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EBI DbfetchID BX842583; SV 1; linear; genomic DNA; STD; PRO; 349606 BP. XX AC BX842583; AL022022; AL022075; AL022121; Z77165; Z82098; Z92774; AC Z95389-Z95390; Z95436; Z95555; Z95557; XX DT 21-NOV-2003 (Rel. 77, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 12/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-349606 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF01066; 6C. DR UniProtKB/Swiss-Prot; Q8VJ11; Y3423_MYCTU. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..349606 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT CDS 63..851 FT /transl_table=11 FT /locus_tag="Rv3400" FT /product="PROBABLE HYDROLASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="3.-.-.-" FT /note="Rv3400, (MTCY78.28c), len: 262 aa. Probable FT hydrolase (EC 3.-.-.-), strongly equivalent to FT Q49741|YY00_MYCLE|ML0393|B1620_F3_119 HYPOTHETICAL 28.6 KDA FT PROTEIN from Mycobacterium leprae (261 aa), FASTA scores: FT opt: 1293, E(): 2.2e-71, (74.45% identity in 262 aa FT overlap). Similar to several various proteins (notably FT hydrolases) e.g. Q9L2I7|SCF42.32 PUTATIVE HYDROLASE from FT Streptomyces coelicolor (246 aa), FASTA scores: opt: 888, FT E(): 7.7e-47, (56.35% identity in 245 aa overlap); FT Q9EX06|2SCG38.13 PUTATIVE HYDROLASE from Streptomyces FT coelicolor (238 aa), FASTA scores: opt: 195, E(): 8.1e-05, FT (29.5% identity in 234 aa overlap); Q9I5X4|PA0562 PROBABLE FT HYDROLASE from Pseudomonas aeruginosa (224 aa), FASTA FT scores: opt: 190, E(): 0.00015, (27.8% identity in 248 aa FT overlap); O06995|PGMB_BACSU|YVDM PUTATIVE FT BETA-PHOSPHOGLUCOMUTASE from Bacillus subtilis (226 aa), FT FASTA scores: opt: 190, E(): 0.00016, (33.9% identity in FT 245 aa overlap); etc. Also similar to Mycobacterium FT tuberculosis hypothetical protein FT Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa), FASTA FT scores: opt: 413, E(): 2e-17, (34.9% identity in 238 aa FT overlap). Interestingly, note that Rv3400 and Rv3401 are FT similar to beginning and end of FT Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 FT aa missing from the middle." FT /db_xref="GOA:P65069" FT /db_xref="InterPro:IPR005834" FT /db_xref="InterPro:IPR006402" FT /db_xref="InterPro:IPR010976" FT /db_xref="UniProtKB/Swiss-Prot:P65069" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01023.1" FT /translation="MANWYRPNYPEVRSRVLGLPEKVRACLFDLDGVLTDTASLHTKAW FT KAMFDAYLAERAERTGEKFVPFDPAADYHTYVDGKKREDGVRSFLSSRAIEIPDGSPDD FT PGAAETVYGLGNRKNDMLHKLLRDDGAQVFDGSRRYLEAVTAAGLGVAVVSSSANTRDV FT LATTGLDRFVQQRVDGVTLREEHIAGKPAPDSFLRAAELLGVTPDAAAVFEDALSGVAA FT GRAGNFAVVVGINRTGRAAQAAQLRRHGADVVVTDLAELL" FT CDS 866..3226 FT /transl_table=11 FT /locus_tag="Rv3401" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN; PROBABLY ENZYME INVOLVED IN CELLULAR FT METABOLISM." FT /note="Rv3401, (MTCY78.27c), len: 786 aa. Hypothetical FT conserved protein, may be an hydrolase or a transferase, FT equivalent to Q49736|ML0392|B1620_F1_30 HYPOTHETICAL 88.1 FT KDA PROTEIN from Mycobacterium leprae (792 aa), FASTA FT scores: opt: 4820, E(): 0, (91.45% identity in 782 aa FT overlap). Also highly similar to Q9L2I8|SCF42.31c PUTATIVE FT GLYCOSYL TRANSFERASE from Streptomyces coelicolor (792 aa), FT FASTA scores: opt: 3060, E(): 2.9e-179, (59.25% identity in FT 785 aa overlap); and similar to others e.g. Q9K109|NMB0390 FT MALTOSE PHOSPHORYLASE from Neisseria meningitidis FT (serogroup B) (752 aa), FASTA scores: opt: 980, E(): FT 3.5e-52, (29.2% identity in 774 aa overlap); FT Q9JSW8|MAPA|NMA2098 PUTATIVE MALTOSE PHOSPHORYLASE (EC FT 2.4.1.8) from Neisseria meningitidis (serogroup A) (752 FT aa), FASTA scores: opt: 956, E(): 1e-50, (28.4% identity in FT 764 aa overlap); O06993|YVDK_BACSU HYPOTHETICAL 88.3 KDA FT PROTEIN (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from FT Bacillus subtilis (757 aa), FASTA scores: opt: 926, E(): FT 6.9e-49, (28.5% identity in 754 aa overlap); Q9CF04|MAPA FT MALTOSEPHOSPHORYLASE from Lactococcus lactis (subsp. FT lactis) (Streptococcus lactis) (751 aa), FASTA scores: opt: FT 907, E(): 1e-47, (26.95% identity in 753 aa overlap); FT P77154|YCJT_ECOLI|B1316 HYPOTHETICAL 84.9 KDA PROTEIN FT (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from FT Escherichia coli strain K12 (755 aa), FASTA scores: opt: FT 392, E(): 2.9e-16, (27.5% identity in 774 aa overlap); etc. FT Also similar to Mycobacterium tuberculosis hypothetical FT protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 FT aa), (27.2% identity in 802 aa overlap); note that Rv3400 FT and Rv3401 are similar to beginning and end of FT Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 FT aa missing from the middle." FT /db_xref="GOA:Q50724" FT /db_xref="InterPro:IPR005194" FT /db_xref="InterPro:IPR005195" FT /db_xref="InterPro:IPR005196" FT /db_xref="InterPro:IPR008928" FT /db_xref="InterPro:IPR011013" FT /db_xref="InterPro:IPR012341" FT /db_xref="InterPro:IPR017045" FT /db_xref="UniProtKB/Swiss-Prot:Q50724" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01022.1" FT /translation="MITEDAFPVEPWQVRETKLNLNLLAQSESLFALSNGHIGLRGNLD FT EGEPFGLPGTYLNSFYEIRPLPYAEAGYGYPEAGQTVVDVTNGKIFRLLVGDEPFDVRY FT GELISHERILDLRAGTLTRRAHWRSPAGKQVKVTSTRLVSLAHRSVAAIEYVVEAIEEF FT VRVTVQSELVTNEDVPETSADPRVSAILDRPLQAVEHERTERGALLMHRTRASALMMAA FT GMEHEVEVPGRVEITTDARPDLARTTVICGLRPGQKLRIVKYLAYGWSSLRSRPALRDQ FT AAGALHGARYSGWQGLLDAQRAYLDDFWDSADVEVEGDPECQQAVRFGLFHLLQASARA FT ERRAIPSKGLTGTGYDGHAFWDTEGFVLPVLTYTAPHAVADALRWRASTLDLAKERAAE FT LGLEGAAFPWRTIRGQESSAYWPAGTAAWHINADIAMAFERYRIVTGDGSLEEECGLAV FT LIETARLWLSLGHHDRHGVWHLDGVTGPDEYTAVVRDNVFTNLMAAHNLHTAADACLRH FT PEAAEAMGVTTEEMAAWRDAADAANIPYDEELGVHQQCEGFTTLAEWDFEANTTYPLLL FT HEAYVRLYPAQVIKQADLVLAMQWQSHAFTPEQKARNVDYYERRMVRDSSLSACTQAVM FT CAEVGHLELAHDYAYEAALIDLRDLHRNTRDGLHMASLAGAWTALVVGFGGLRDDEGIL FT SIDPQLPDGISRLRFRLRWRGFRLIVDANHTDVTFILGDGPGTQLTMRHAGQDLTLHTD FT TPSTIAVRTRKPLLPPPPQPPGREPVHRRALAR" FT CDS complement(3477..4715) FT /transl_table=11 FT /locus_tag="Rv3402c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN; THOUGHT TO BE INVOLVED IN CELL FT PROCESS." FT /note="Rv3402c, (MTCY78.26), len: 412 aa. Conserved FT hypothetical protein, probably involved in cell process, FT similar to various proteins generally involved in FT extracellular compounds (lipopolysaccharide O-antigen) FT biosynthesis e.g. O68392|RFBE PEROSAMINE SYNTHETASE from FT Brucella melitensis (367 aa), FASTA scores: opt: 420, E(): FT 1.2e-19, (26.15% identity in 375 aa overlap); Q9L6C1 FT 3,4-DEHYDRATASE-LIKE PROTEIN from Streptomyces antibioticus FT (393 aa), FASTA scores: opt: 419, E(): 1.5e-19, (30.65% FT identity in 385 aa overlap); Q9RR26|OLENI DEHYDRATASE from FT Streptomyces antibioticus (393 aa), FASTA scores: opt: 416, FT E(): 2.3e-19, (30.65% identity in 385 aa overlap); O33942 FT ERYCIV PROTEIN from Saccharopolyspora erythraea FT (Streptomyces erythraeus) (401 aa), FASTA scores: opt: 410, FT E(): 5.6e-19, (31.75% identity in 362 aa overlap); FT Q9UZI4|ASPB-LIKE1|PAB0774 ASPARTATE AMINOTRANSFERASE FT (ASPB-LIKE1) from Pyrococcus abyssi (366 aa), FASTA scores: FT opt: 402, E(): 1.7e-18, (27.05% identity in 377 aa FT overlap); O88001|WLBC PUTATIVE AMINO-SUGAR BIOSYNTHESIS FT PROTEIN from Bordetella bronchiseptica (Alcaligenes FT bronchisepticus) (366 aa), FASTA scores: opt: 394, E(): FT 5.6e-18, (26.8% identity in 347 aa overlap); Q45378|BPLC FT DNA FOR LIPOPOLYSACCHARIDE BIOSYNTHESIS from Bordetella FT pertussis (366 aa), FASTA scores: opt: 393, E(): 6.5e-18, FT (26.8% identity in 347 aa overlap); etc." FT /db_xref="GOA:Q50723" FT /db_xref="InterPro:IPR000653" FT /db_xref="InterPro:IPR015421" FT /db_xref="InterPro:IPR015422" FT /db_xref="InterPro:IPR015424" FT /db_xref="UniProtKB/Swiss-Prot:Q50723" FT /protein_id="CAB01021.1" FT /translation="MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSF FT PGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHV FT SFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRDR FT IAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFS FT FHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLR FT QLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSL FT RRHAIEARDYYNPPQHRHPYFVTNAELVESTDLAVTADICSRIVSLPVHDHMAPDDVAR FT VVAAVQEAEVRGE" FT CDS complement(5086..6687) FT /transl_table=11 FT /locus_tag="Rv3403c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3403c, (MTCY78.25), len: 533 aa. Hypothetical FT unknown protein, but some weak similarity to Q9KJP2 FT HYPOTHETICAL 54.9 KDA PROTEIN from Myxococcus xanthus (504 FT aa), FASTA scores: opt: 157, E(): 0.011, (24.1% identity in FT 548 aa overlap)." FT /db_xref="GOA:P65071" FT /db_xref="UniProtKB/Swiss-Prot:P65071" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01020.1" FT /translation="MLAFPYLMTMITPPTFDVAFIGSGAACSMTLLEMADALLSSPSAS FT PKLRIAVVERDEQFWCGIPYGQRSSIGSLAIQKLDDFADEPEKAAYRIWLEQNKQRWLA FT FFQAEGGAAAARWICDNRDALDGNQWGELYLPRFLFGVFLSEQMIAAIAALGERDLAEI FT VTIRAEAMSAHSADGHYRIGLRPSGNGPTAIAAGKVVVAIGSPPTKAILASDSEPAFTY FT INDFYSPGGESNVARLRDSLDRVESWEKRNVLVVGSNATSLEALYLMRHDARIRARVRS FT ITVISRSGVLPYMICNQPPEFDFPRLRTLLCTEAIAAADLMSAIRDDLATAEERSLNLA FT DLYDAVAALFGQALHKMDLVQQEEFFCVHGMNFTKLVRRAGRDCRQASEELAADGTLSL FT LAGEVLRVDACASGQPFATMTYRAAGAEHTHPVPFAAVVNCGGFEELDTCSSPFLVSAM FT QNGLCRPNRTNRGLLVNDDFEASPGFCVIGPLVGGNFTPKIRFWHVESAPRVRSLAKSL FT AASLLASLQPVALAPC" FT CDS complement(6704..7408) FT /transl_table=11 FT /locus_tag="Rv3404c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3404c, (MTCY78.24), len: 234 aa. Conserved FT hypothetical protein, some similarity to several FT METHIONYL-TRNA FORMYLTRANSFERASES e.g. BAB51418|MLL4854 FT from Rhizobium loti (Mesorhizobium loti) (317 aa), FASTA FT scores: opt: 210, E(): 1.7e-06, (27.55% identity in 178 aa FT overlap); P94463|FMT_BACSU from Bacillus subtilis (317 aa), FT FASTA scores: opt: 199 ,E(): 8.8e-06, (28.25% identity in FT 177 aa overlap); O51091||FMT_BORBU|BB0064 from Borrelia FT burgdorferi (Lyme disease spirochete) (312 aa), FASTA FT scores: opt: 187, E(): 5.2e-05, (30.2% identity in 192 aa FT overlap); etc." FT /db_xref="GOA:P65073" FT /db_xref="InterPro:IPR002376" FT /db_xref="InterPro:IPR015518" FT /db_xref="UniProtKB/Swiss-Prot:P65073" FT /protein_id="CAB01019.1" FT /translation="MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVA FT ERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKV FT GVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTA FT KSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFV FT RVVLEPEKPAEA" FT CDS complement(7526..8092) FT /transl_table=11 FT /locus_tag="Rv3405c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="MAY BE INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv3405c, (MTCY78.23), len: 188 aa. Possible FT transcriptional regulator, showing weak similarity to other FT bacterial regulatory proteins e.g. Q9KE70|BH0987 from FT Bacillus halodurans (203 aa), FASTA scores: opt: 168, E(): FT 0.0016, (34.8% identity in 92 aa overlap); Q9A5F7|CC2493 FT Caulobacter crescentus (204 aa), FASTA scores: opt: 160, FT E(): 0.0051, (32.6% identity in 89 aa overlap); FT Q9RDR0|SC4A7.02 from Streptomyces coelicolor (227 aa), FT FASTA scores: opt: 159, E(): 0.0064, (37.0% identity in 189 FT aa overlap); etc. Also some similarity to hypothetical FT Mycobacterium tuberculosis regulatory proteins e.g. FT O05858|Rv3208|MTCY07D11.18c, MTCI125_6, MTCY7D11_18, FT MTCY10G2_30; etc. Contains potential helix-turn-helix motif FT from aa 39-60 (+2.97 SD)." FT /db_xref="GOA:P67442" FT /db_xref="InterPro:IPR001647" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/Swiss-Prot:P67442" FT /protein_id="CAB01018.1" FT /translation="MTTRPATDRRKMPTGREEVAAAILQAATDLFAERGPAATSIRDIA FT ARSKVNHGLVFRHFGTKDQLVGAVLDHLGTKLTRLLHSEAPADIIERALDRHGRVLARA FT LLDGYPVGQLQQRFPNVAELLDAVRPRYDSDLGARLAVAHALALQFGWRLFAPMLRSAT FT GIDELTGDELRLSVNDAVARILEPH" FT CDS 8154..9041 FT /transl_table=11 FT /locus_tag="Rv3406" FT /product="PROBABLE DIOXYGENASE" FT /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3406, (MTCY78.22c), len: 295 aa. Probable FT dioxygenase (EC 1.-.-.-), highly similar to Q9WWU|ATSK FT PUTATIVE ALPHA-KETOGLUTARATE DEPENDENT DIOXYGENASE from FT Pseudomonas putida (301 aa), FASTA scores: opt: 994, E(): FT 3.9e-57, (53.7% identity in 283 aa overlap); Q9I6U1|PA0193 FT HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa), FT FASTA scores: opt: 1024, E(): 4.4e-59, (53.65% identity in FT 287 aa overlap); Q9HX81|TAUD|PA3935 TAURINE DIOXYGENASE FT from Pseudomonas aeruginosa (277 aa), FASTA scores: opt: FT 599, E(): 1.4e-31, (39.35% identity in 277 aa overlap); and FT similar to other dioxygenases e.g. AAG54718|TAUD (alias FT BAB33845|ECS0422) TAURINE DIOXYGENASE FT 2-OXOGLUTARATE-DEPENDENT from Escherichia coli strain FT O157:H7 (283 aa), FASTA scores: opt: 595, E(): 2.5e-31, FT (38.1% identity in 281 aa overlap); etc. BELONGS TO THE FT TFDA FAMILY OF DIOXYGENASES." FT /db_xref="GOA:P65075" FT /db_xref="InterPro:IPR003819" FT /db_xref="UniProtKB/Swiss-Prot:P65075" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01017.1" FT /translation="MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVV FT FFRGQHQLDDAEQLAFAGLLGTPIGHPAAIALADDAPIITPINSEFGKANRWHTDVTFA FT ANYPAASVLRAVSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKP FT LTAAQRAFRQVFEKPDFRTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVL FT QRRITMPENTIRWNWAPGDVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQ FT ASRVISGAPMEIAG" FT CDS 9076..9375 FT /transl_table=11 FT /locus_tag="Rv3407" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3407, (MTCY78.21c), len: 99 aa. Hypothetical FT protein, similar to other hypothetical proteins from FT Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. FT AAK46285|MT2013 (90 aa), FASTA scores: opt: 160, E(): FT 0.00021, (37.1% identity in 89 aa overlap); FT O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 155, FT E(): 0.00051, (41.05% identity in 78 aa overlap), FT MTCY19H5.26, MTCY20H10.07, MTI376.09c, MTCY427.21, etc." FT /db_xref="InterPro:IPR003756" FT /db_xref="InterPro:IPR006442" FT /db_xref="UniProtKB/Swiss-Prot:P65077" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01016.1" FT /translation="MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARL FT IPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRTLSDVLNEMRDEQ" FT CDS 9372..9782 FT /transl_table=11 FT /locus_tag="Rv3408" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3408, (MTCY78.20c), len: 136 aa. Hypothetical FT protein, similar to other hypothetical proteins from FT Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. FT O50411|Rv3384c|MTV004.42c (130 aa), FASTA scores: opt: 243, FT E(): 1.7e-09, (35.1% identity in 131 aa overlap); FT P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: FT 191, E(): 5e-06, (35.5% identity in 138 aa overlap), etc." FT /db_xref="UniProtKB/Swiss-Prot:Q50717" FT /protein_id="CAB01015.1" FT /translation="MIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVE FT SMRVVARYGQPGQTERARYLLDGLDILPLTEPVIGLAETIGPATLRSLDAIHLAAAAQI FT KRELTAFVTYDHRLLSGCREVGFVTASPGAVR" FT CDS complement(9815..11551) FT /transl_table=11 FT /gene="choD" FT /locus_tag="Rv3409c" FT /product="PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD FT (CHOLESTEROL-O2 OXIDOREDUCTASE)" FT /function="INVOLVED IN CHOLESTEROL METABOLISM [CATALYTIC FT ACTIVITY: CHOLESTEROL + O(2) = CHOLEST-4-EN-3-ONE + FT H(2)O(2)]." FT /EC_number="1.1.3.6" FT /note="Rv3409c, (MTCY78.19), len: 578 aa. Probable choD, FT cholesterol oxidase precursor (EC 1.1.3.6), equivalent to FT Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240) FT PUTATIVE CHOLESTEROL OXIDASE from Mycobacterium leprae (569 FT aa), FASTA scores: opt: 3510, E(): 3.8e-198, (88.6% FT identity in 569 aa overlap). Also highly similar to FT Q9L0H6|SCD63.13 PUTATIVE CHOLESTEROL OXIDASE from FT Streptomyces coelicolor (602 aa), FASTA scores: opt: 1101, FT E(): 5.2e-57, (60.05% identity in 586 aa overlap); and FT similar to other oxidoreductases e.g. Q9A7T6|CC1634 FT OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus FT (579 aa), FASTA scores: opt: 221, E(): 1.8e-05, (25.2% FT identity in 583 aa overlap). BELONGS TO THE GMC FT OXIDOREDUCTASES FAMILY. COFACTOR: FAD FLAVOPROTEIN. FT Contains PS00017 ATP/GTP-binding site motif A." FT /db_xref="GOA:Q57307" FT /db_xref="HSSP:3COX" FT /db_xref="InterPro:IPR006076" FT /db_xref="UniProtKB/TrEMBL:Q57307" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01014.1" FT /translation="MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEFA FT KTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLNYANTLYVPPEPFFADQ FT QWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRIVKEVADEMGFGDTWVPTPVGVF FT FGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGA FT QVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMR FT DRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEPVR FT YGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQWSERTVIA FT LVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIPIGNQVTRRIAAKIDGVAGGT FT WGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLS FT IAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSN FT AG" FT misc_feature complement(11027..11050) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(11607..12734) FT /transl_table=11 FT /gene="guaB3" FT /locus_tag="Rv3410c" FT /product="PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE FT GUAB3 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) FT (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) FT (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD)" FT /function="CATALYSES THE FIRST REACTION UNIQUE TO GMP FT BIOSYNTHESIS [CATALYTIC ACTIVITY: INOSINE 5'-PHOSPHATE + FT NAD(+) + H(2)O = XANTHOSINE 5'-PHOSPHATE + NADH]." FT /EC_number="1.1.1.205" FT /note="Rv3410c, (MTCY78.18), len: 375 aa. Probable guaB3, FT inosine-5'-monophosphate (IMP) dehydrogenase (EC FT 1.1.1.205), equivalent to FT Q49721|YY10_MYCLE|ML0388|B1620_C2_193 HYPOTHETICAL 38.9 KDA FT PROTEIN from Mycobacterium leprae (375 aa), FASTA scores: FT opt: 2182, E(): 9.5e-122, (90.6% identity in 373 aa FT overlap). Highly similar to Q9RHY9 GUAB ORF GENES FOR IMP FT DEHYDROGENASE, HYPOTHETICAL PROTEIN from Corynebacterium FT ammoniagenes (Brevibacterium ammoniagenes) (376 aa), FASTA FT scores: opt: 1490, E(): 7.6e-81, (61.0% identity in 382 aa FT overlap); Q9L0I6|SCD63.03 PUTATIVE INOSINE-5'-MONOPHOSPHATE FT DEHYDROGENASE from Streptomyces coelicolor (374 aa), FASTA FT scores: opt: 1275, E(): 3.8e-68, (52.95% identity in 372 aa FT overlap); P73853|GUAB|SLR1722 IMP DEHYDROGENASE SUBUNIT FT from Synechocystis sp. strain PCC 6803 (387 aa), FASTA FT scores: opt: 882, E(): 6.7e-45, (41.3% identity in 373 aa FT overlap); and similar to other inosine-5'-monophosphate FT dehydrogenases e.g. P44334|IMDH_HAEIN|GUAB|HI0221 from FT Haemophilus influenzae (488 aa), FASTA scores: opt: 267, FT E(): 1.8e-08, (34.25% identity in 216 aa overlap); etc. FT Also highly similar to the C-terminus of Q50753|GUAA/B FT HOMOLOGY TO Mycobacterium leprae GUAA (FRAGMENT) from FT Mycobacterium tuberculosis (130 aa), FASTA scores: opt: FT 506, E(): 4.6e-23, (85.05% identity in 87 aa overlap). FT SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO FT GMP REDUCTASE." FT /db_xref="GOA:P65170" FT /db_xref="InterPro:IPR001093" FT /db_xref="InterPro:IPR005992" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/Swiss-Prot:P65170" FT /protein_id="CAB01013.1" FT /translation="MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFE FT IPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPS FT TAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVI FT QGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGST FT QGVTTTDEVLGISVPMATAIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIAC FT GADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDD FT PFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG" FT CDS complement(12754..14343) FT /transl_table=11 FT /gene="guaB2" FT /locus_tag="Rv3411c" FT /product="PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE FT GUAB2 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) FT (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) FT (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD)" FT /function="CATALYSES THE FIRST REACTION UNIQUE TO GMP FT BIOSYNTHESIS [CATALYTIC ACTIVITY: INOSINE 5'-PHOSPHATE + FT NAD(+) + H(2)O = XANTHOSINE 5'-PHOSPHATE + NADH]." FT /EC_number="1.1.1.205" FT /note="Rv3411c, (MTCY78.17), len: 529 aa. Probable guaB2, FT inosine-5'-monophosphate (IMP) dehydrogenase (EC FT 1.1.1.205), equivalent to FT Q49729|IMDH_MYCLE|GUAB|ML0387|B1620_C3_238 FT INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE from Mycobacterium FT leprae (529 aa), FASTA scores: opt: 3154, E(): 4.4e-165, FT (92.45% identity in 529 aa overlap). Highly similar to FT other inosine-5'-monophosphate dehydrogenases e.g. FT Q9RHZ0|GUAB from Corynebacterium ammoniagenes FT (Brevibacterium ammoniagenes) (506 aa), FASTA scores: opt: FT 2284, E(): 1.5e-117, (67.9% identity in 505 aa overlap); FT Q9L0I7|SCD63.02 from Streptomyces coelicolor (501 aa), FT FASTA scores: opt: 2178, E(): 9e-112, (67.2% identity in FT 491 aa overlap); O67820|IMDH_AQUAE|GUAB|AQ_2023 from FT Aquifex aeolicus (490 aa), FASTA scores: opt: 1820, E(): FT 3.2e-92, (58.1% identity in 487 aa overlap); etc. Also FT similar to Q50716|YY10_MYCTU|Rv3410c|MT3518|MTCY78.18 FT HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium FT tuberculosis (38.6% identity in 158 aa overlap). Contains FT PS00487 IMP dehydrogenase / GMP reductase signature. FT SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO FT GMP REDUCTASE." FT /db_xref="GOA:P65167" FT /db_xref="InterPro:IPR000644" FT /db_xref="InterPro:IPR001093" FT /db_xref="InterPro:IPR005990" FT /db_xref="InterPro:IPR013785" FT /db_xref="InterPro:IPR015875" FT /db_xref="InterPro:IPR018529" FT /db_xref="UniProtKB/Swiss-Prot:P65167" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01012.1" FT /translation="MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGL FT TFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMG FT VLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDD FT GALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVD FT GRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLV FT VDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSI FT CTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSL FT LAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPE FT GIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDV FT AMTVEAPNYYAR" FT misc_feature complement(13315..13353) FT /note="PS00487 IMP dehydrogenase / GMP reductase signature" FT CDS 14550..14960 FT /transl_table=11 FT /locus_tag="Rv3412" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3412, (MTCY78.16c), len: 136 aa. Hypothetical FT protein, strongly similar to FT Q49742|YY12_MYCLE|ML0386|B1620_F3_131 HYPOTHETICAL 15.3 KDA FT PROTEIN from Mycobacterium leprae (137 aa), FASTA scores: FT opt: 933, E(): 6.3e-52, (93.4% identity in 136 aa FT overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P65079" FT /protein_id="CAB01011.1" FT /translation="MRDHLPPGLPPDPFADDPCDPSAALEAVEPGQPLDQQERMAVEAD FT LADLAVYEALLAHKGIRGLVVCCDECQQDHYHDWDMLRSNLLQLLIDGTVRPHEPAYDP FT EPDSYVTWDYCRGYADASLNEAAPDADRFRRR" FT CDS complement(14970..15869) FT /transl_table=11 FT /locus_tag="Rv3413c" FT /product="HYPOTHETICAL ALANINE AND PROLINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv3413c, (MTCY78.16), len: 299 aa. Hypothetical FT unknown ala-, pro-rich protein." FT /db_xref="GOA:P65081" FT /db_xref="UniProtKB/Swiss-Prot:P65081" FT /protein_id="CAB01010.1" FT /translation="MREFGNPLGDRPPLDELARTDLLLDALAEREEVDFADPRDDALAA FT LLGQWRDDLRWPPASALVSQDEAVAALRAGVAQRRRARRSLAAVGSVAAALLVLSGFGA FT VVADARPGDLLYGLHAMMFNRSRVSDDQIVLSAKANLAKVEQMIAQGQWAEAQDELAEV FT SSTVQAVTDGSRRQDLINEVNLLNTKVETRDPNATLRPGSPSNPAAPGSVGNSWTPLAP FT VVEPPTPPTPASAAEPSMSAGVSESPMPNSTSTVAASPSTPSSKPEPGSIDPSLEPADE FT ATNPAGQPAPETPVSPTH" FT CDS complement(15862..16500) FT /transl_table=11 FT /gene="sigD" FT /locus_tag="Rv3414c" FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA-D FT FACTOR SIGD" FT /function="THE SIGMA FACTOR IS AN INITIATION FACTOR THAT FT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC FT INITIATION SITES AND THEN IS RELEASED." FT /note="Rv3414c, (MTCY78.15), len: 212 aa. Probable sigD, FT alternative RNA polymerase sigma-D factor (see citations FT below), similar to others (notably from Streptomyces FT coelicolor) e.g. Q9L0I8|SCD63.01 from Streptomyces FT coelicolor (195 aa), FASTA scores: opt: 533, E(): 9.6e-28, FT (47.25% identity in 182 aa overlap); Q9FDS3|ADSA from FT Streptomyces griseus (258 aa), FASTA scores: opt: 223, E(): FT 1.8e-07, (28.95% identity in 183 aa overlap); FT BAB48649|MLL1224 from Rhizobium loti (Mesorhizobium loti) FT (187 aa), FASTA scores: opt: 202, E(): 3.2e-06, (30.4% FT identity in 194 aa overlap); FT P38133|RPOE_STRCO|SIGE|SCE94.07 from Streptomyces FT coelicolor (176 aa), FASTA scores: opt: 200, E(): 4.1e-06, FT (35.25% identity in 156 aa overlap); P37978|CNRH_ALCEU from FT Alcaligenes eutrophus (Ralstonia eutropha), FASTA scores: FT opt: 197, E(): 6.9e-06, (30.35% identity in 191 aa FT overlap); etc. C-terminus strongly similar to N-terminal FT part of Q49727|S1620B|B1620_C3_233 HYPOTHETICAL 6.2 KDA FT PROTEIN from Mycobacterium leprae (59 aa), FASTA scores: FT opt: 217, E(): 1.3e-07, (90.25% identity in 41 aa overlap). FT BELONGS TO THE SIGMA-70 FACTOR FAMILY." FT /db_xref="GOA:P66811" FT /db_xref="InterPro:IPR000838" FT /db_xref="InterPro:IPR007627" FT /db_xref="InterPro:IPR013249" FT /db_xref="InterPro:IPR013324" FT /db_xref="InterPro:IPR013325" FT /db_xref="InterPro:IPR014284" FT /db_xref="UniProtKB/Swiss-Prot:P66811" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01009.1" FT /translation="MVDPGVSPGCVRFVTLEISPSMTMQGERLDAVVAEAVAGDRNALR FT EVLETIRPIVVRYCRARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYG FT IAAHKVADAHRAAGRDRAYPAETLPERWSADAGPEQMAIEADSVTRMNELLEILPAKQR FT EILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAAGDYA" FT CDS complement(16518..17345) FT /transl_table=11 FT /locus_tag="Rv3415c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3415c, (MTCY78.14), len: 275 aa. Conserved FT hypothetical protein, equivalent to Q9CCV3|ML0383 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa), FT FASTA scores: opt: 1278, E(): 4.2e-71, (73.5% identity in FT 279 aa overlap). Also some similarity with FT P71677|RIBD_MYCTU|RIBG|Rv1409|MT1453|MTCY21B4.26 RIBOFLAVIN FT BIOSYNTHESIS PROTEIN R (339 aa), FASTA scores: opt: 143, FT E(): 0.13, (28.25% identity in 184 aa overlap)." FT /db_xref="InterPro:IPR011717" FT /db_xref="UniProtKB/TrEMBL:Q50711" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01008.1" FT /translation="MNETPHAPVVEQVLVAAAFGNQPGSWPLPTAITPHHLWLRAVAAG FT GQGRYAHAYGDLSVLRRLVPAGPLASLAHSTQGSLLRQLGWHTLARGWDGRALALAGAD FT REAGADALIGLAADALGVGRFAAAGALLDRADPLVVSPLVADRLAVRRRWVAAELAMAT FT GDGATAVRHAEEAVELTQAMAVASARHRVKSDVVLAAALCSAGAVARARAVGEEALDAT FT ARFGLLPLRWALACLLIDIGTVTFSAQQLRELTKIRNICAGQVRRAGGCWRTA" FT CDS 17716..18024 FT /transl_table=11 FT /gene="whiB3" FT /locus_tag="Rv3416" FT /standard_name="whmB" FT /product="TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE FT WHIB3" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM (GROWTH FT PHASE-DEPENDENT)." FT /note="Rv3416, (MTCY78.13c), len: 102 aa. whiB3 (alternate FT gene name: whmB), WhiB-like regulatory protein (see FT citations below), similar to WhiB paralogue of Streptomyces FT coelicolor, wblE gene product (85 aa). Equivalent to FT Q49871|WHIB3|WHIB|ML0382|B229_F1_2|B1620_F3_137 PROBABLE FT TRANSCRIPTION FACTOR WHIB3 from Mycobacterium leprae (102 FT aa), FASTA scores: opt: 657, E(): 7.9e-39, (86.25% identity FT in 102 aa overlap). Also highly similar to Q9Z6E9|WHIB3 FT from Mycobacterium smegmatis (96 aa), FASTA scores: opt: FT 604, E(): 3.5e-35, (80.4% identity in 102 aa overlap); and FT O88103|WHID|SC6G4.45c|WBLB from Streptomyces coelicolor FT (112 aa), FASTA scores: opt: 437, E(): 1.4e-23, (62.5% FT identity in 96 aa overlap). Also similar to FT O05847|WHIB1|Rv3219|MTCY07D11.07c from Mycobacterium FT tuberculosis (84 aa), FASTA scores: opt: 215, E(): 2.5e-08, FT (44.45% identity in 81 aa overlap). Note that primer FT extension analysis revealed three transcriptional start FT sites and that expression from the three potential FT promoters is growth phase-dependent (see Mulder et al., FT 1999). Moreover, the transcription of this CDS seems to be FT activated in macrophages (see Ramakrishnan et al., 2000)." FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q50710" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01007.1" FT /translation="MPQPEQLPGPNADIWNWQLQGLCRGMDSSMFFHPDGERGRARTQR FT EQRAKEMCRRCPVIEACRSHALEVGEPYGVWGGLSESERDLLLKGTMGRTRGIRRTA" FT CDS complement(18096..19715) FT /transl_table=11 FT /gene="groEL1" FT /locus_tag="Rv3417c" FT /standard_name="cpn60_1" FT /product="60 KDA CHAPERONIN 1 GROEL1 (PROTEIN CPN60-1) FT (GROEL PROTEIN 1)" FT /function="PREVENTS MISFOLDING AND PROMOTES THE REFOLDING FT AND PROPER ASSEMBLY OF UNFOLDED POLYPEPTIDES GENERATED FT UNDER STRESS CONDITIONS." FT /note="Rv3417c, (MTCY78.12), len: 539 aa. groEL1 (alternate FT genbe name: cpn60_1), 60 kDa chaperonin 1 (protein cpn60 1) FT (see citations below), equivalent to FT P37578|CH61_MYCLE|B1620_C3_228|GROL1|GROEL1|GROEL-1|GROE1 FT |M L0381|B229_ 60 KDA CHAPERONIN 1 from Mycobacterium FT leprae (537 aa), FASTA scores: opt: 2846, E(): 1.5e-154, FT (82.95% identity in 539 aa overlap). Also highly similar to FT others e.g. Q00767|CH61_STRAL|GROL1|GROEL1 from FT Streptomyces albus G (539 aa), FASTA scores: opt: 2130, FT E(): 8.1e-114, (61.9% identity in 541 aa overlap); FT P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces FT coelicolor (540 aa), FASTA scores: opt: 2119, E(): FT 3.4e-113, (61.8% identity in 542 aa overlap); etc. Also FT similar to FT P06806|CH62_MYCTU|Q48931|Rv0440|MTV037.04|GROL2|GROEL2|GR FT OE L-2|HSP65 (62.2% identity in 527 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A, PS00296 Chaperonins FT cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY." FT /db_xref="GOA:P0A518" FT /db_xref="InterPro:IPR001844" FT /db_xref="InterPro:IPR002423" FT /db_xref="InterPro:IPR018370" FT /db_xref="UniProtKB/Swiss-Prot:P0A518" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01006.1" FT /translation="MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGG FT PTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLR FT LVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEA FT MSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQ FT DKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGD FT RRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAV FT ANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVA FT AAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANA FT GLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTT FT ETVVVDKPAKAEDHDHHHGHAH" FT misc_feature complement(18474..18509) FT /note="PS00296 Chaperonins cpn60 signature" FT misc_feature complement(19293..19316) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(19810..20112) FT /transl_table=11 FT /gene="groES" FT /locus_tag="Rv3418c" FT /standard_name="cpn10; mpt57" FT /product="10 KDA CHAPERONIN GROES (PROTEIN CPN10) (PROTEIN FT GROES) (BCG-A HEAT SHOCK PROTEIN) (10 KDA ANTIGEN)" FT /function="BINDS TO CPN60 IN THE PRESENCE OF MG-ATP AND FT SUPPRESSES THE ATPASE ACTIVITY OF THE LATTER." FT /note="Rv3418c, (MTCY78.11), len: 100 aa. groES (alternate FT gene names: cpn10, mpt57), 10 kDa chaperonin (protein FT cpn10) (see citations below), equivalent to FT P24301|CH10_MYCLE|MOPB|GROES|CHPA|ML0380|B1620_C3_227|B22 FT 9_ C3_247 from Mycobacterium leprae (99 aa), FASTA scores: FT opt: 568, E(): 2.1e-31, (89.9% identity in 99 aa overlap). FT And also strongly identical to others e.g. FT O86017|CH10_MYCAV|MOPB|GROES from Mycobacterium avium and FT Mycobacterium paratuberculosis (99 aa), FASTA scores: opt: FT 611, E(): 2.9e-34, (96.95% identity in 99 aa overlap); FT P15020|CH10_MYCBO|MOPB|GROES from Mycobacterium bovis (99 FT aa), FASTA scores: opt: 596, E(): 2.9e-33, (98.95% identity FT in 94 aa overlap); P40172|CH10_STRCO|GROES|SC6G4.39 from FT Streptomyces coelicolor and Streptomyces lividans (102 aa), FT FASTA scores: opt: 480, E(): 1.6e-25, (76.75% identity in FT 99 aa overlap); etc. Also identical to MSG10KAG_1, FT MT10KAG_1, MTBCGA_1. Contains PS00681 Chaperonins cpn10 FT signature. BELONGS TO THE GROES CHAPERONIN FAMILY." FT /db_xref="GOA:P09621" FT /db_xref="InterPro:IPR001476" FT /db_xref="InterPro:IPR011032" FT /db_xref="InterPro:IPR018369" FT /db_xref="InterPro:IPR020818" FT /db_xref="PDB:1HX5" FT /db_xref="PDB:1P3H" FT /db_xref="PDB:1P83" FT /db_xref="UniProtKB/Swiss-Prot:P09621" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01005.1" FT /translation="MAKVNIKPLEDKILVQANEAETTTASGLVIPDTAKEKPQEGTVVA FT VGPGRWDEDGEKRIPLDVAEGDTVIYSKYGGTEIKYNGEEYLILSARDVLAVVSK" FT misc_feature complement(20023..20097) FT /note="PS00681 Chaperonins cpn10 signature" FT CDS complement(20379..21413) FT /transl_table=11 FT /gene="gcp" FT /locus_tag="Rv3419c" FT /product="PROBABLE O-SIALOGLYCOPROTEIN ENDOPEPTIDASE GCP FT (GLYCOPROTEASE)" FT /function="HYDROLYSIS OF O-SIALOGLYCOPROTEINS; CLEAVES FT 31-ARG-|-ASP-32 BOND IN GLYCOPHORIN A. DOES NOT CLEAVE FT UNGLYCOSYLATED PROTEINS, DESIALYLATED GLYCOPROTEINS OR FT GLYCOPROTEINS THAT ARE ONLY N-GLYCOSYLATED. COULD BE A FT METALLOPROTEASE." FT /EC_number="3.4.24.57" FT /note="Rv3419c, (MTCY78.10), len: 344 aa. Probable gcp, FT glycoprotease (EC 3.4.24.57), equivalent to FT P37969|GCP_MYCLE|GCP|ML0379|U229E|U1620c|B229_C3_246|B162 FT 0_ C3_226 PROBABLE GLYCOPROTEASE from Mycobacterium leprae FT (351 aa), FASTA scores: opt: 1898, E(): 2.4e-101, (86.1% FT identity in 345 aa overlap). Highly similar to others e.g. FT O86793|GCP_STRCO|GCP|SC6G4.30 from Streptomyces coelicolor FT (374 aa), FASTA scores: opt: 1282, E(): 4.1e-66, (60.45% FT identity in 344 aa overlap); Q9WXZ2|TM0145 from Thermotoga FT maritima (327 aa), FASTA scores: opt: 867, E(): 1.9e-42, FT (45.4% identity in 337 aa overlap); P05852|GCP_ECOLI|B3064 FT from Escherichia coli strain K12 (337 aa), FASTA scores: FT opt: 838, E(): 9e-41, (46.55% identity in 346 aa overlap); FT etc. Shows some similarity to FT Q50707|YY21_MYCTU|Rv3421c|MTCY78.08 (33.9% identity in 127 FT aa overlap). Contains PS01016 Glycoprotease family FT signature. BELONGS TO PEPTIDASE FAMILY M22; ALSO KNOWN AS FT THE GLYCOPROTEASE FAMILY." FT /db_xref="GOA:P65801" FT /db_xref="InterPro:IPR000905" FT /db_xref="InterPro:IPR009180" FT /db_xref="InterPro:IPR017860" FT /db_xref="InterPro:IPR017861" FT /db_xref="UniProtKB/Swiss-Prot:P65801" FT /protein_id="CAB01004.1" FT /translation="MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFG FT GVVPEIASRAHLEALGPAMRRALAAAGLKQPDIVAATIGPGLAGALLVGVAAAKAYSAA FT WGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGSTVDD FT AAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTA FT VARYVESHAADPGFRTADIAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRL FT RELATQRCGEAGRTLRIPSPRLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDPGLPVMQ FT GQVR" FT misc_feature complement(21057..21119) FT /note="PS01016 Glycoprotease family signature" FT CDS complement(21410..21886) FT /transl_table=11 FT /gene="rimI" FT /locus_tag="Rv3420c" FT /product="PROBABLE RIBOSOMAL-PROTEIN-ALANINE FT ACETYLTRANSFERASE RIMI (ACETYLATING ENZYME FOR N-TERMINAL FT OF RIBOSOMAL PROTEIN S18)" FT /function="THIS ENZYME ACETYLATES THE N-TERMINAL ALANINE OF FT RIBOSOMAL PROTEIN S18 [CATALYTIC ACTIVITY: ACETYL-COA + FT RIBOSOMAL-PROTEIN L-ALANINE = CoA + RIBOSOMAL-PROTEIN FT N-ACETYL-L-ALANINE]." FT /EC_number="2.3.1.128" FT /note="Rv3420c, (MTCY78.09), len: 158 aa. Probable rimI, FT ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), FT equivalent to C-terminal part of FT Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA FT PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: FT opt: 772, E(): 2.7e-44, (72.1% identity in 154 aa overlap). FT Similar notably to ribosomal-protein-alanine FT acetyltransferases e.g. Q9AC11|CC0058 from Caulobacter FT crescentus (150 aa), FASTA scores: opt: 223, E(): 4.9e-08, FT (37.5% identity in 136 aa overlap); Q9KFD4|BH0547 from FT Bacillus halodurans (151 aa), FASTA scores: opt: 222, E(): FT 5.8e-08, (35.2% identity in 142 aa overlap); Q9PG61|XF0441 FT from Xylella fastidiosa (156 aa), FASTA scores: opt: 207, FT E(): 5.9e-07, (32.2% identity in 149 aa overlap); FT Q9HVB7|RIMI|PA4678 from Pseudomonas aeruginosa (150 aa), FT FASTA scores: opt: 203, E(): 1.1e-06, (32.45% identity in FT 151 aa overlap); P09453|RIMI_ECOLI|B4373 from Escherichia FT coli strain K12 (148 aa), FASTA scores: opt: 196, E(): FT 3.1e-06, (33.55% identity in 149 aa overlap); etc. BELONGS FT TO THE ACETYLTRANSFERASE FAMILY, RIMI SUBFAMILY." FT /db_xref="GOA:Q50708" FT /db_xref="HSSP:1P0H" FT /db_xref="InterPro:IPR000182" FT /db_xref="InterPro:IPR006464" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q50708" FT /protein_id="CAB01003.1" FT /translation="MTADTEPVTIGALTRADAQRCAELEAQLFVGDDPWPPAAFNRELA FT SPHNHYVGARSGGTLVGYAGISRLGRTPPFEYEVHTIGVDPAYQGRGIGRRLLRELLDF FT ARGGVVYLEVRTDNDAALALYRSVGFQRVGLRRRYYRVSGADAYTMRRDSGDPS" FT CDS complement(21883..22518) FT /transl_table=11 FT /locus_tag="Rv3421c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3421c, (MTCY78.08), len: 211 aa. Conserved FT hypothetical protein, equivalent to FT Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA FT PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: FT opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa FT overlap). Also similar to other hypothetical bacterial FT proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor FT (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% FT identity in 212 aa overlap); Q9AC10|CC0059 (GLYCOPROTEASE FT FAMILY PROTEIN) from Caulobacter crescentus (211 aa), FASTA FT scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa FT overlap); Q9KQK9|VC1989 from Vibrio cholerae (237 aa), FT FASTA scores: opt: 238, E(): 8.2e-07, (28.85% identity in FT 208 aa overlap); BAB51966|Mlr5530 from Rhizobium loti FT (Mesorhizobium loti) (225 aa), FASTA scores: opt: 237, E(): FT 9e-07, (35.0% identity in 220 aa overlap); etc. Some FT similarity to upstream FT Q50709|GCP_MYCTU|Rv3419c|MT3528|MTCY78.10 from FT Mycobacterium tuberculosis (344 aa), (33.9% identity in 127 FT aa overlap)." FT /db_xref="GOA:P65083" FT /db_xref="InterPro:IPR000905" FT /db_xref="UniProtKB/Swiss-Prot:P65083" FT /protein_id="CAB01035.1" FT /translation="MSRVQISTVLAIDTATPAVTAGIVRRHDLVVLGERVTVDARAHAE FT RLTPNVLAALADAALTMADLDAVVVGCGPGPFTGLRAGMASAAAYGHALGIPVYGVCSL FT DAIGGQTIGDTLVVTDARRREVYWARYCDGIRTVGPAVNAAADVDPGPALAVAGAPEHA FT ALFALPCVEPSRPSPAGLVAAVNWADKPAPLVPLYLRRPDAKPLAVCT" FT CDS complement(22515..23021) FT /transl_table=11 FT /locus_tag="Rv3422c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3422c, (MTCY78.07), len: 168 aa. Conserved FT hypothetical protein, equivalent to FT Q49864|YY22_MYCLE|ML0377|U229F|B229_C2_205 HYPOTHETICAL FT 17.6 KDA PROTEIN from Mycobacterium leprae (161 aa), FASTA FT scores: opt: 752, E(): 8.3e-38, (77.4% identity in 146 aa FT overlap). Also similar to other hypothetical bacterial FT proteins e.g. O86788|YJEE_STRCO|SC6G4.25 from Streptomyces FT coelicolor (148 aa), FASTA scores: opt: 377, E(): 1.2e-15, FT (50.85% identity in 120 aa overlap); Q9X1W7|TM1632 from FT Thermotoga maritima (161 aa), FASTA scores: opt: 247, E(): FT 6.2e-08, (39.4% identity in 137 aa overlap); Q9RRY1|DR2351 FT from Deinococcus radiodurans (148 aa), FASTA scores: opt: FT 236, E(): 2.6e-07, (38.6% identity in 127 aa overlap); etc. FT Contains PS00017 ATP /GTP-binding site motif A." FT /db_xref="GOA:P67171" FT /db_xref="InterPro:IPR003442" FT /db_xref="UniProtKB/Swiss-Prot:P67171" FT /protein_id="CAB01034.1" FT /translation="MSREGIRRRPKARAGLTGGGTATLPRVEDTLTLGSRLGEQLCAGD FT VVVLSGPLGAGKTVLAKGIAMAMDVEGPITSPTFVLARMHRPRRPGTPAMVHVDVYRLL FT DHNSADLLSELDSLDLDTDLEDAVVVVEWGEGLAERLSQRHLDVRLERVSHSDTRIATW FT SWGRS" FT misc_feature complement(22848..22871) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(23018..24244) FT /transl_table=11 FT /gene="alr" FT /locus_tag="Rv3423c" FT /product="ALANINE RACEMASE ALR" FT /function="PROVIDES THE D-ALANINE REQUIRED FOR CELL WALL FT BIOSYNTHESIS. TRANSFORMS L-ALANINE to D-ALANINE [CATALYTIC FT ACTIVITY: L-ALANINE = D-ALANINE]" FT /EC_number="5.1.1.1" FT /note="Rv3423c, (MTCY78.06), len: 408 aa. alr, alanine FT racemase (EC 5.1.1.1), equivalent to FT P38056|ALR_MYCLE|ML0375|B229_C3_243 ALANINE RACEMASE from FT Mycobacterium leprae (388 aa), FASTA scores: opt: 2160, FT E(): 2.3e-124, (84.35% identity in 384 aa overlap). Also FT highly similar to other alanine racemases e.g. FT Q9L888|ALR_MYCAV from Mycobacterium avium (391 aa), FASTA FT scores: opt: 2103, E(): 6.8e-121, (83.6% identity in 384 aa FT overlap); P94967|ALR_MYCSM from Mycobacterium smegmatis FT (389 aa), FASTA scores: opt: 1721, E(): 1.3e-97, (67.25% FT identity in 385 aa overlap); O86786|ALR_STRCO|SC6G4.23 from FT Streptomyces coelicolor (391 aa), FASTA scores: opt: 1041, FT E(): 3.7e-56, (47.65% identity in 380 aa overlap); etc. FT Contains Pfam entry PF00842 Alanine racemase. BELONGS TO FT THE ALANINE RACEMASE FAMILY." FT /db_xref="GOA:P0A4X2" FT /db_xref="InterPro:IPR000821" FT /db_xref="InterPro:IPR001608" FT /db_xref="InterPro:IPR009006" FT /db_xref="InterPro:IPR011079" FT /db_xref="InterPro:IPR020622" FT /db_xref="PDB:1XFC" FT /db_xref="UniProtKB/Swiss-Prot:P0A4X2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01033.1" FT /translation="MKRFWENVGKPNDTTDGRGTTSLAMTPISQTPGLLAEAMVDLGAI FT EHNVRVLREHAGHAQLMAVVKADGYGHGATRVAQTALGAGAAELGVATVDEALALRADG FT ITAPVLAWLHPPGIDFGPALLADVQVAVSSLRQLDELLHAVRRTGRTATVTVKVDTGLN FT RNGVGPAQFPAMLTALRQAMAEDAVRLRGLMSHMVYADKPDDSINDVQAQRFTAFLAQA FT REQGVRFEVAHLSNSSATMARPDLTFDLVRPGIAVYGLSPVPALGDMGLVPAMTVKCAV FT ALVKSIRAGEGVSYGHTWIAPRDTNLALLPIGYADGVFRSLGGRLEVLINGRRCPGVGR FT ICMDQFMVDLGPGPLDVAEGDEAILFGPGIRGEPTAQDWADLVGTIHYEVVTSPRGRIT FT RTYREAENR" FT CDS complement(24538..24900) FT /transl_table=11 FT /locus_tag="Rv3424c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3424c, (MTCY78.05), len: 120 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P65085" FT /protein_id="CAB01032.1" FT /translation="MPNPVTMLYGRKADLVILPHVLAEERPHPYSTPGRKRGAQIALTT FT GIDALASFAPQIVNPRHGLSRVVQCLGGCENKRHAYFRSISKTPHIRARGVPSVCAVRT FT VGVDGAKRPPKPIPVQ" FT CDS 25063..25593 FT /transl_table=11 FT /gene="PPE57" FT /locus_tag="Rv3425" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3425, (MTCY78.04c), len: 176 aa. Member of the M. FT tuberculosis PPE family, similar to many e.g. FT O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt: 781, FT E(): 7e-44, (69.9% identity in 176 aa overlap); and FT downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FT FASTA scores: opt: 517, E(): 1.2e-26, (68.0% identity in FT 125 aa overlap); MTV049_11, MTCY428_16, MTV049_22, FT MTV049_30, MTCY261_4; etc." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q50703" FT /protein_id="CAE55596.1" FT /translation="MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESLE FT DELDELDENWKGSSSDLLADAVERYLQWLSKHSSQLKHAAWVINGLANAYNDTRRKVVP FT PEEIAANREERRRLIASNVAGVNTPAIADLDAQYDQYRARNVAVMNAYVSWTRSALSDL FT PRWREPPQIYRGG" FT CDS 25860..26558 FT /transl_table=11 FT /gene="PPE58" FT /locus_tag="Rv3426" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3426, (MTCY78.03c), len: 232 aa. Member of the M. FT tuberculosis PPE family, similar to many e.g. the FT downstream O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: FT opt: 555, E(): 6.5e-26, (72.0% identity in 125 aa overlap); FT and upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FT FASTA scores: opt: 517, E(): 1.1e-23, (68.0% identity in FT 125 aa overlap); MTV049_30, MTCY3C7_24, MTCY428_16, FT MTCY3A2_22; etc." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q50702" FT /protein_id="CAE55597.1" FT /translation="MHLMIPAEYISNVIYEGPRADSLYAADQRLRQLADSVRTTAESLN FT TTLDELHENWKGSSSEWMADAALRYLDWLSKHSRQILRTARVIESLVMAYEETLLRVVP FT PATIANNREEVRRLIASNVAGGKHSSNRRPRGTIRAVPGRKYPSNGPLSKLDPICAIEA FT APMAGAAADPQERVGPRGRRGLAGQQQCRGRPGPSLRCSHDTPRFQMNQAFHTMVNMLL FT TCFACQEKPR" FT CDS complement(26709..27464) FT /transl_table=11 FT /locus_tag="Rv3427c" FT /product="POSSIBLE TRANSPOSASE" FT /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION FT SEQUENCE IS1532." FT /note="Rv3427c, (MTCY78.02), len: 251 aa. Possible FT transposase, similar to other e.g. Q9APG8|ORF2 PUTATIVE FT TRANSPOSASE SUBUNIT 2 from Pseudomonas putida (251 aa), FT FASTA scores: opt: 479, E(): 1.8e-21, (34.85% identity in FT 238 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A." FT /db_xref="GOA:Q50701" FT /db_xref="InterPro:IPR002611" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:Q50701" FT /protein_id="CAB01029.1" FT /translation="MSICDPALRNALRTLKLSGMLDTLDARLAQTRNGDLGHLEFLQAL FT REDEIARRESAALTRRLRRAKFEAQATFEDFDFTANPKLPGAMLRDLAALRWLDAGESV FT ILHGPVGVGKTHVAQALVHAVARRGGDVRFAKTSRMLSDLAGGHADRSWGQRIREYTKP FT LVLILDDFAMREHTAMHADDLYELISDRAITGKPLILTSNRAPNNWYGLFPNPVVAESL FT LDRLINTSHQILMDGPSYRPRKRPGRTTS" FT repeat_region complement(26712..28794) FT /mobile_element="insertion sequence:IS1532" FT /note="IS1532, len: 2083 bp. Insertion sequence IS1532." FT misc_feature complement(27120..27143) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(27562..28794) FT /transl_table=11 FT /locus_tag="Rv3428c" FT /product="POSSIBLE TRANSPOSASE" FT /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION FT SEQUENCE IS1532." FT /note="Rv3428c, (MTCY78.01, len: 410 aa. Possible FT transposase INSERTION SEQUENCE, similar to others e.g. FT Q9APG9|ORF1 from Pseudomonas putida (509 aa), FASTA scores: FT opt: 578, E(): 1.1e-29, (32.45% identity in 376 aa FT overlap); P55379|Y4BL_RHISN from Rhizobium sp. strain FT NGR234 (516 aa), FASTA scores: opt: 665, E(): 2.7e-35, FT (35.3% identity in 391 aa overlap); etc." FT /db_xref="GOA:Q50700" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/Swiss-Prot:Q50700" FT /protein_id="CAB01028.1" FT /translation="MATIAQRLRDDHGVAASESSVRRWIATHFAEEVARERVTVPRGPV FT DAGSEAQIDYGRLGMWFDPATARRVAVWAFVMVLAFSRHLFVRPVIRMDQTAWCACHVA FT AFEFFDGVPARLVCDNLRTGVDKPDLYDPQINRSYAELASHYATLVDPARARKPKDKPR FT VERPMTYVRDSFWKGREFDSLAQMQQAAVTWSTEVAGLRYLRALEGAQPLRMFEAVEQQ FT ALIALPPRAFELTSWSIGTVGVDTHLKVGKALYSVPWRLIGQRLHARTAGDVVQIFAGN FT DVVATHVRRPSGRSTDFSHYPPEKIAFHMRTPTWCRHTAELVGPASQQVIAEFMRDNAI FT HHLRSAQGVLGLRDKHGCDRLEAACARAIEVGDPSYRTIKGILVAGTEHAANEPTTSSP FT ASTAGGVPARP" FT CDS 29989..30525 FT /transl_table=11 FT /gene="PPE59" FT /locus_tag="Rv3429" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3429, (MTCY77.01), len: 178 aa. Member of the M. FT tuberculosis PPE family, similar to many e.g. the upstream FT Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FASTA scores: FT opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); FT and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA FT scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa FT overlap) (but diverges at 3' end)); etc." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:O06246" FT /protein_id="CAE55598.1" FT /translation="MHPMIPAEYISNIIYEGPGADSLSAAAEQLRLMYNSANMTAKSLT FT DRLGELQENWKGSSSDLMADAAGRYLDWLTKHSRQILETAYVIDFLAYVYEETRHKVVP FT PATIANNREEVHRLIASNVAGVNTPAIAGLDAQYQQYRAQNIAVMNDYQSTARFILAYL FT PRWQEPPQIYGGGGG" FT CDS complement(30466..31629) FT /transl_table=11 FT /locus_tag="Rv3430c" FT /product="POSSIBLE TRANSPOSASE" FT /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION FT SEQUENCE IS1540." FT /note="Rv3430c, (MTCY77.02c), len: 387 aa. Possible IS1540 FT transposase, similar to several e.g. Q49592 transposase FT from Mycobacterium intracellulare (340 aa), FASTA scores: FT opt: 1377, E(): 1.6e-81, (64.2% identity in 338 aa FT overlap); similarity is lost at C-terminus due to possible FT frameshift after aa 297." FT /db_xref="GOA:O06247" FT /db_xref="InterPro:IPR001584" FT /db_xref="InterPro:IPR012337" FT /db_xref="UniProtKB/TrEMBL:O06247" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08679.1" FT /translation="MIDTAIEEMIPLIGVRAACAATGRAPASYYRAHSKRLSAQSDTFT FT STAVTDPSGPRESAQPRALSAAEREHVLAVLNSQRFADMAPAVVYATLLDEGIYLCSES FT TMYRLLRERGQTGDRRRQATHPAAVKPELVAHQPNSVWSWDITKLRGPAKWSYYYLYVI FT LDIFSRYVVGWMVASRESKVLAERLIAQTLAAQHISADQLTLHADRGSSMSSKPVALLL FT ADLGVTKSHSRPHTSNDNPLSEAQFKTLKYRPDFPKRFESIEAARVHCDRFFGWYNHEH FT KHSGIGLHTPADVHYGRADQIRRHRATVLDTAYRDHLERIRSQTTRATRATGLQRDQPT FT TEGGPADSINPRKSCLRNVDRFRPGLLDLPAPAPVDLRRLLPSGQIR" FT repeat_region complement(30468..31630) FT /mobile_element="insertion sequence:IS1540" FT /note="IS1540, len: 1163 bp. Insertion sequence IS1540." FT CDS complement(32118..32963) FT /transl_table=11 FT /locus_tag="Rv3431c" FT /product="POSSIBLE TRANSPOSASE (FRAGMENT)" FT /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION FT SEQUENCE IS1552" FT /note="Rv3431c, (MTCY77.03c), len: 281 aa. Possible FT truncated transposase for IS1552, similar to, but shorter FT than other transposases e.g. P72303 from Rhodococcus opacus FT (418 aa), FASTA scores: opt: 1509, E(): 1.2e-91, (80.95% FT identity in 278 aa overlap); Q9AKV5 from Mycobacterium FT paratuberculosis (395 aa), FASTA scores: opt: 1115, E(): FT 7.8e-66, (63.45% identity in 268 aa overlap); etc." FT /db_xref="GOA:O06248" FT /db_xref="InterPro:IPR001207" FT /db_xref="UniProtKB/TrEMBL:O06248" FT /protein_id="CAB08680.1" FT /translation="MFAELIRAGLQALIEAEATEAIGAGRYERSDGRIVHRNGHRPKTV FT STTAGDIEVQIPKLRAGSFFPSLLERRRRIDKALHAVIMEAYVHGVSTRSVDDLVAAMG FT VQAGVSKSEVSRICAGLDTEIEAFRTRSLTHTEFPYVFCDATFCKVRVGAHVVSQALVV FT ATGVSIDGTREVLGTAVGDSESYEFWREFLASLKARGLTGVHLVISDAHAGLKAAVAQQ FT FSGASWQRCRVHFMRNLYTAVAAKHAPAVTVAVKTIFAHTDPEEVGAQWDRVADPLCQP FT " FT repeat_region complement(32120..32964) FT /mobile_element="insertion sequence:IS1552" FT /note="IS1552, len: 845 bp. Insertion sequence IS1552." FT CDS complement(33196..34578) FT /transl_table=11 FT /gene="gadB" FT /locus_tag="Rv3432c" FT /product="PROBABLE GLUTAMATE DECARBOXYLASE GADB" FT /function="CATALYZES THE PRODUCTION OF GABA [CATALYTIC FT ACTIVITY: L-GLUTAMATE = 4-AMINOBUTANOATE + CO(2)]." FT /EC_number="4.1.1.15" FT /note="Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB, FT glutamate decarboxylase (EC 4.1.1.15), similar to many e.g. FT P73043|GAD|SLL1641 from Synechocystis sp. strain PCC 6803 FT (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% FT identity in 457 aa overlap); Q9X8J5|SCE9.23 from FT Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650, FT E(): 8.9e-97, (57.4% identity in 446 aa overlap); FT Q9AQU4|GAD from Oryza sativa (Rice) (501 aa), FASTA scores: FT opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa FT overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) FT (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15% FT identity in 437 aa overlap); etc. BELONGS TO GROUP II FT DECARBOXYLASES (DDC, GAD, HDC AND TYRDC)." FT /db_xref="GOA:O06249" FT /db_xref="HSSP:1PMM" FT /db_xref="InterPro:IPR002129" FT /db_xref="InterPro:IPR010107" FT /db_xref="InterPro:IPR015421" FT /db_xref="InterPro:IPR015424" FT /db_xref="UniProtKB/TrEMBL:O06249" FT /protein_id="CAB08681.1" FT /translation="MSRSHPSVPAHSIAPAYTGRMFTAPVPALRMPDESMDPEAAYRFI FT HDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPATAAIEARCVSMVA FT DLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKWRWRQRVGSWKGRMPNLVMGSNV FT QVVWEKFCRYFDVEPRYLPMERGRYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIA FT EICAALDKLAAGGGVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLT FT YPGVGFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRLGRDGY FT TKVMQALSHTARWLGDQLREVDHCEVISDGSAIPVVSFRLAGDRGYTEFDVSHELRTFG FT WQVPAYTMPDNATDVAVLRIVVREGLSADLARALHDDAVTALAALDKVKPGGHFDAQHF FT AH" FT CDS complement(34616..36037) FT /transl_table=11 FT /locus_tag="Rv3433c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3433c, (MTCY77.05), len: 473 aa. Hypothetical FT protein, member of YKL151c/yjeF family, equivalent to FT P37391|YY33_MYCLE|ML0373|U229G|B229_C2_201 HYPOTHETICAL FT 47.2 KDA PROTEIN from Mycobacterium leprae (473 aa), FASTA FT scores: opt: 2650, E(): 5e-136, (84.55% identity in 473 aa FT overlap). Also similar to other hypothetical bacterial FT proteins e.g. Q9X3W3 from Zymomonas mobilis (484 aa), FASTA FT scores: opt: 700, E(): 1.2e-30, (33.7% identity in 484 aa FT overlap); O86783|SC6G4.20c from Streptomyces coelicolor FT (485 aa), FASTA scores: opt: 563, E(): 3.2e-23, (48.45% FT identity in 489 aa overlap); Q9LC81 from Arthrobacter sp. FT Q36 (313 aa), FASTA scores: opt: 553, E(): 7.9e-23, (44.2% FT identity in 303 aa overlap); etc. Contains Pfam match to FT entry PF01256 hypothetical UPFOO31 family signature and FT PF03853 YjeF-related protein N-terminus. BELONGS TO THE FT UPF0031 FAMILY." FT /db_xref="InterPro:IPR000631" FT /db_xref="InterPro:IPR004443" FT /db_xref="InterPro:IPR017953" FT /db_xref="UniProtKB/Swiss-Prot:O06250" FT /protein_id="CAB08682.1" FT /translation="MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTAR FT TGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGG FT RLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGA FT ITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPG FT PRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIAS FT PTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRN FT APTVLTPHAGEFARLAGAPPGDDRVGACRQLADALGATVLLKGNVTVIADPGGPVYLNP FT AGQSWAATAGSGDVLSGMIGALLASGLPSGEAAAAAAFVHARASAAAAADPGPGDAPTS FT ASRISGHIRAALAAL" FT misc_feature complement(35060..35086) FT /note="PS01050 Hypothetical YKL151c/yjeF family signature FT 2" FT misc_feature complement(35132..35161) FT /note="PS01049 Hypothetical YKL151c/yjeF family signature FT 1" FT CDS complement(36039..36752) FT /transl_table=11 FT /locus_tag="Rv3434c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3434c, (MTCY77.06c), len: 237 aa. Possible FT conserved transmembrane protein, showing some similarity FT with Q9CGH7|YLDB HYPOTHETICAL PROTEIN from Lactococcus FT lactis (subsp. lactis) (Streptococcus lactis) (258 aa), FT FASTA scores: opt: 248, E(): 1.6e-09, (28.8% identity in FT 198 aa overlap); and P94983|Rv1648|MTCY06H11.13 from FT Mycobacterium tuberculosis (268 aa), FASTA scores: opt: FT 205, E(): 1.2e-06, (31.45% identity in 194 aa overlap)." FT /db_xref="GOA:O06251" FT /db_xref="UniProtKB/TrEMBL:O06251" FT /protein_id="CAB08683.1" FT /translation="MADASVVARLRSWALAVWHFVSNAPLTYAWLVVLVITTIIQNNLT FT GSQLHFVLLHRSTNIAELGRDPLEVLFSSLLWIDGRNLEPYLLLFTLFLAPAEHWLGHL FT RWLTVGLTAHIGATYLSEGLLYLAIQHRDASERMVHARDIGVSYFLVGVMAVLTYHIAK FT PWRWGYLGVLLVIFGFPLIAMDKAELDFTAVGHFASILIGLLFYPMARERDGRLWNPAR FT IKSLLHRRGTRGRRA" FT CDS complement(36763..37617) FT /transl_table=11 FT /locus_tag="Rv3435c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3435c, (MTCY77.07c), len: 284 aa. Probable FT conserved transmembrane protein, showing some similarity FT with P95061|Rv0713|MTCY210.32 HYPOTHETICAL 33.9 KDA PROTEIN FT from Mycobacterium tuberculosis (313 aa), FASTA scores: FT opt: 557, E(): 1.3e-26, (35.8% identity in 282 aa overlap); FT and O32991|MLCB2492.12 from Mycobacterium leprae (95 aa), FT FASTA scores: opt: 150, E(): 0.022, (35.3% identity in 85 FT aa overlap). Equivalent to AAK47881 from Mycobacterium FT tuberculosis strain CDC1551 (312 aa) but shorter 28 aa." FT /db_xref="GOA:O06252" FT /db_xref="UniProtKB/TrEMBL:O06252" FT /protein_id="CAB08684.1" FT /translation="MGRILRVVVGLVLVIAAYVTVIALYHSTGLGRPHEVAHGRPTADG FT TTVTLHVEQLQTIKGVLVANLAVSPGTELLDSQTQGLKDDLTVTVTSVVTPTKRTWSSG FT SLPGVFPVPLTISGDPANWPFDHYRSGPITVQLYRGAAHAPERVSVTFVDRLPGWNVDI FT SGVGDANVPAPYRVGLHRSPSSVAFGTVIVGVLIALAGVGLFVAVQTARGRRQFQPPMT FT TWYAAMLFAVIPLRNALPDAPPIGFWIDVTVVLWVVVALVTSMVLYILCWWWHLKPDVD FT ETM" FT CDS complement(37839..39713) FT /transl_table=11 FT /gene="glmS" FT /locus_tag="Rv3436c" FT /product="PROBABLE GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE FT AMINOTRANSFERASE [ISOMERIZING] GLMS (HEXOSEPHOSPHATE FT AMINOTRANSFERASE) (D-FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE) FT (GFAT) (L-GLUTAMINE-D-FRUCTOSE-6-PHOSPHATE FT AMIDOTRANSFERASE) (GLUCOSAMINE-6-PHOSPHATE SYNTHASE)" FT /function="CATALYZES THE FIRST STEP IN HEXOSAMINE FT METABOLISM, CONVERTING FRUCTOSE-6P INTO GLUCOSAMINE-6P FT USING GLUTAMINE AS A NITROGEN SOURCE [CATALYTIC ACTIVITY: FT L-GLUTAMINE + D-FRUCTOSE 6-PHOSPHATE = L-GLUTAMATE + FT D-GLUCOSAMINE 6-PHOSPHATE]." FT /EC_number="2.6.1.16" FT /note="Rv3436c, (MTCY77.08c), len: 624 aa. Probable glmS, FT glucosamine--fructose-6-phosphate aminotransferase (EC FT 2.6.1.16), equivalent to FT P40831|GLMS_MYCLE|ML0371|B229_C3_238 FT GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE FT [ISOMERIZING] from Mycobacterium leprae (623 aa), FASTA FT scores: opt: 3584, E(): 4.7e-214, (89.3% identity in 627 aa FT overlap). Also highly similar to others e.g. FT O68956|GLMS_MYCSM from Mycobacterium smegmatis (627 aa), FT FASTA scores: opt: 3517, E(): 6.5e-210, (87.25% identity in FT 627 aa overlap); O86781|GLMS_STRCO|SC6G4.18 from FT Streptomyces coelicolor (614 aa), FASTA scores: opt: 2364, FT E(): 1.3e-138, (64.95% identity in 625 aa overlap); FT Q9K1P9|NMB0031 from Neisseria meningitidis (serogroup B) FT and Q9JWN9|GLMS|NMA0276 from Neisseria meningitidis FT (serogroup A) (612 aa), FASTA scores: opt: 1445, E(): FT 8.4e-82, (43.55% identity in 627 aa overlap); etc. BELONGS FT TO THE TYPE-2 GATASE DOMAIN IN THE N-TERMINAL SECTION. FT BELONGS TO THE SIS FAMILY, GLMS SUBFAMILY, IN THE FT C-TERMINAL SECTION." FT /db_xref="GOA:P0A588" FT /db_xref="InterPro:IPR000583" FT /db_xref="InterPro:IPR001347" FT /db_xref="InterPro:IPR005855" FT /db_xref="InterPro:IPR017932" FT /db_xref="UniProtKB/Swiss-Prot:P0A588" FT /protein_id="CAB08685.1" FT /translation="MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVR FT RRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNG FT IIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRLEGH FT FTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVI FT TADGYRISDFDGNDGLQAGRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLL FT GHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELAS FT EFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAV FT LYTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVAR FT VIAATGPVAELAHRFAQSSTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHG FT PIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTIVIAEEGDETVRPYADH FT LIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE" FT CDS 39735..40211 FT /transl_table=11 FT /locus_tag="Rv3437" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3437, (MTCY77.09), len: 158 aa. Questionable ORF. FT Possible conserved transmenbrane protein, C-terminus FT similar to N-terminal part of O06345|Rv3482c|MTCY13E12.35c FT HYPOTHETICAL 28.5 KDA PROTEIN from Mycobacterium FT tuberculosis (260 aa), FASTA scores: opt: 140, E(): 0.1, FT (58.8% identity in 34 aa overlap); and Q9XAN5|SC4C6.05c FT PUTATIVE MEMBRANE PROTEIN from Streptomyces (347 aa), FT coelicolor FASTA scores: opt: 112, E(): 6.8, (50.0% FT identity in 32 aa overlap)." FT /db_xref="GOA:O06254" FT /db_xref="InterPro:IPR018929" FT /db_xref="UniProtKB/TrEMBL:O06254" FT /protein_id="CAB08686.1" FT /translation="MVGRAVPSPNRRYRRVWPPRTKGQHLSNPYAQHQLKLIRHTGALI FT LWQQRTYVVSGTREQCEAAYKSAQTYNLLVGWWSLVSLLAMNWIALISNFNAIRRVRAA FT ADGASVPHGPHAIAHPAVPRGPIPAGWYPDPSGAGLRYWDGATWTHWTHPPRHR" FT CDS 40221..41063 FT /transl_table=11 FT /locus_tag="Rv3438" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3438, (MTCY77.10), len: 280 aa. Conserved FT hypothetical protein, equivalent to Q9CCV6|ML0370 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (289 aa), FT FASTA scores: opt: 1491, E(): 9.2e-81, (79.85% identity in FT 283 aa overlap); and highly similar (but shorter 41 aa) to FT Q49872|B229_F1_20 HYPOTHETICAL 34.0 KDA PROTEIN from FT Mycobacterium leprae (324 aa), FASTA scores: opt: 1491, FT E(): 1e-80, (79.85% identity in 283 aa overlap). Shows some FT similarity to Q9KIU3|LIPA LIPASE from plasmid pAH114 FT uncultured bacterium (281 aa), FASTA scores: opt: 168, E(): FT 0.0081, (29.3% identity in 140 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06255" FT /protein_id="CAB08687.1" FT /translation="MPRIRKLVAALHRRGPHRVLRGDLAFAGLPGVVYTPEAGLHLPGV FT AFGHDWLTGTSRYSGLLEHLASWGIVAAAPDSERGLAPSVLNLAFDLGVALDIVAGVRL FT GPGKISVHPAKLGLVGHGFGGSAAVFAAAGLTGTHVKSVAAIFPTVTNPAAEQPAATLD FT VPGLILTAPGDPKTLTSNALGLSRAWDKATLRIVSKARAGGLVEGRRLTKVLGLPGPHR FT RTQRSVRALLTGYLLYTLGGDKTYRRFADPDLQLPKTDPIDPEAPPITPGEKIVTLLK" FT CDS complement(41083..42486) FT /transl_table=11 FT /locus_tag="Rv3439c" FT /product="CONSERVED HYPOTHETICAL ALANINE AND PROLINE RICH FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv3439c, (MTCY77.11c), len: 467 aa. Conserved FT hypothetical ala-, pro-rich protein, similar in part to FT N-terminal part of Q49853|B229_C1_154 HYPOTHETICAL 11.2 KDA FT PROTEIN from Mycobacterium leprae (103 aa), FASTA scores: FT opt: 265, E(): 0.0013, (51.1% identity in 90 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06256" FT /protein_id="CAB08688.1" FT /translation="MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPAQI FT HDWYGSEDGLDLHALDADCAQLRAAASVLMEALRMERSQVAVLAAAWTGSGADAAVHFV FT QRHCETGNSVVTEVRAAAQRCESLRDNLWQLVDSKVATAIAIDERALAQRPAWLAAAEA FT LTTEGADRPTAVEVVRQQIQPYVDDDVRNDWLTTMRSTTAGVAASYDAVTDQLASAPRA FT HFEIPDDLGPGRQPSPASVPAQPSATAAITPAAALPPPDPVPAVTSRPVTPSDFGSAPG FT DGSATPAGVGSAGGFGDAGGTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLGDPLAAD FT NPPGAVDPFAEDAADNADDGDDAHPEEADEAAEPKEATEPDEADEVDDADESVPAERAQ FT DVAEEATLPPVAEPPPPAAPPVAEPPPPVAAPAPPGAPEPANGPSPEALSEGATPCEIA FT ADELPQAGP" FT CDS complement(42489..42800) FT /transl_table=11 FT /locus_tag="Rv3440c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3440c, (MTCY77.12c), len: 103 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O06257" FT /protein_id="CAB08689.1" FT /translation="MRPDSVNSAGIDIAAVYAVADRFSAAAELIDDAIGNHLTRLAFGG FT ACAGRGHASRGDALRCRLDRLAGELSVWSRAAVQIAFALRAGANRYAEADLCAAARIG" FT CDS complement(42848..44194) FT /transl_table=11 FT /gene="mrsA" FT /locus_tag="Rv3441c" FT /product="PROBABLE PHOSPHO-SUGAR MUTASE / MRSA PROTEIN FT HOMOLOG" FT /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM." FT /EC_number="5.4.2.-" FT /note="Rv3441c, (MTCY77.13c), len: 448 aa. Probable mrsA, FT phosphoglucomutase or phosphomannomutase (EC 5.4.2.-), FT equivalent to Q49869|URED|B229_C3_234 MRSA PROTEIN HOMOLOG FT from Mycobacterium leprae (463 aa), FASTA scores: opt: FT 2449, E(): 6.3e-135, (87.65% identity in 445 aa overlap); FT and highly similar (but longer 178 aa) to FT Q49862|UREC|B229_C2_192 PUTATIVE UREASE OPERON UREC PROTEIN FT from Mycobacterium leprae (288 aa), FASTA scores: opt: FT 1442, E(): 1.3e-76, (86.5% identity in 267 aa overlap). FT Highly similar to phospho-sugar mutases e.g. FT Q53876|SC6G4.14 PUTATIVE PHOSPHO-SUGAR MUTASE (SIMILAR TO FT PHOSPHOMANNOMUTASES) from Streptomyces coelicolor (452 aa), FT FASTA scores: opt: 1710, E(): 5e-92, (60.45% identity in FT 450 aa overlap); Q9KG46|BH0267 PHOSPHOGLUCOSAMINE MUTASE FT from Bacillus halodurans (447 aa), FASTA scores: opt: 1351, FT E(): 3.5e-71, (48.4% identity in 444 aa overlap); FT BAB58323|GLMM PHOSPHOGLUCOSAMINE-MUTASE from Staphylococcus FT aureus subsp. aureus Mu50 (451 aa) and FT Q99QR5|GLMM(FEMD)|SA1965 PHOSPHOGLUCOSAMINE-MUTASE from FT Staphylococcus aureus subsp. aureus N315. (451 aa), FASTA FT scores: opt: 1315, E(): 4.3e-69, (48.45% identity in 446 aa FT overlap); P95685|FEMD|GLMM PHOSPHOGLUCOSAMINE-MUTASE (451 FT aa), FASTA scores: opt: 1310, E(): 8.5e-69, (48.2% identity FT in 446 aa overlap); P95575|MRSA_PSESY MRSA PROTEIN HOMOLOG FT from Pseudomonas syringae (pv. syringae) (447 aa), FASTA FT scores: opt: 1143, E(): 4.2e-59, (42.75% identity in 447 aa FT overlap); etc. Contains PS00710 Phosphoglucomutase and FT phosphomannomutase phosphoserine signature. BELONGS TO THE FT PHOSPHOHEXOSE MUTASES FAMILY." FT /db_xref="GOA:O06258" FT /db_xref="InterPro:IPR005841" FT /db_xref="InterPro:IPR005843" FT /db_xref="InterPro:IPR005844" FT /db_xref="InterPro:IPR005845" FT /db_xref="InterPro:IPR005846" FT /db_xref="InterPro:IPR006352" FT /db_xref="InterPro:IPR016055" FT /db_xref="InterPro:IPR016066" FT /db_xref="UniProtKB/Swiss-Prot:O06258" FT /protein_id="CAB08690.1" FT /translation="MGRLFGTDGVRGVANRELTAELALALGAAAARRLSRSGAPGRRVA FT VLGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTGAYDADFGVMISASHN FT PMPDNGIKIFGPGGHKLDDDTEDQIEDLVLGVSRGPGLRPAGAGIGRVIDAEDATERYL FT RHVAKAATARLDDLAVVVDCAHGAASSAAPRAYRAAGARVIAINAEPNGRNINDGCGST FT HLDPLRAAVLAHRADLGLAHDGDADRCLAVDANGDLVDGDAIMVVLALAMKEAGELACN FT TLVATVMSNLGLHLAMRSAGVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIVMPALGS FT TGDGIVTGLRLMTRMVQTGSSLSDLASAMRTLPQVLINVEVVDKATAAAAPSVRTAVEQ FT AAAELGDTGRILLRPSGTEPMIRVMVEAADEGVAQRLAATVADAVSTAR" FT misc_feature complement(43865..43909) FT /note="PS00710 Phosphoglucomutase and phosphomannomutase FT phosphoserine signature" FT CDS complement(44319..44774) FT /transl_table=11 FT /gene="rpsI" FT /locus_tag="Rv3442c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S9 RPSI" FT /function="INVOLVED IN TRANSLATION MECHANISM. THIS PROTEIN FT IS ONE OF THE ASSEMBLY PROTEINS OF THE 50S RIBOSOMAL FT SUBUNIT." FT /note="Rv3442c, (MTCY77.14c), len: 151 aa. Probable rpsI, FT ribosomal protein S9, equivalent to FT P40828|RS9_MYCLE|ML0365|B229_C2_191 30S RIBOSOMAL PROTEIN FT S9 (153 aa), FASTA scores: opt: 800, E(): 2.1e-42, (83.85% FT identity in 155 aa overlap). Also highly similar to others FT e.g. Q53875|RS9_STRCO|SC6G4.13 from Streptomyces coelicolor FT (170 aa), FASTA scores: opt: 533, E(): 5.7e-26, (60.75% FT identity in 135 aa overlap); Q9KGD4|RPSI|BH0169 (BS10) from FT Bacillus halodurans (130 aa), FASTA scores: opt: 469, E(): FT 3.8e-22, (58.65% identity in 121 aa overlap); Q9CDG7|RPSI FT from Lactococcus lactis (subsp. lactis) (Streptococcus FT lactis) (130 aa), FASTA scores: opt: 451, E(): 4.9e-21, FT (58.65% identity in 121 aa overlap); P07842|RS9_BACST|RPSI FT from Bacillus stearothermophilus (129 aa), FASTA scores: FT opt: 448, E(): 7.4e-21, (54.55% identity in 121 aa FT overlap); etc. Contains PS00360 Ribosomal protein S9 FT signature. BELONGS TO THE S9P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P66639" FT /db_xref="InterPro:IPR000754" FT /db_xref="InterPro:IPR014721" FT /db_xref="InterPro:IPR020568" FT /db_xref="InterPro:IPR020574" FT /db_xref="UniProtKB/Swiss-Prot:P66639" FT /protein_id="CAB08691.1" FT /translation="MTETTPAPQTPAAPAGPAQSFVLERPIQTVGRRKEAVVRVRLVPG FT TGKFDLNGRSLEDYFPNKVHQQLIKAPLVTVDRVESFDIFAHLGGGGPSGQAGALRLGI FT ARALILVSPEDRPALKKAGFLTRDPRATERKKYGLKKARKAPQYSKR" FT misc_feature complement(44451..44507) FT /note="PS00360 Ribosomal protein S9 signature" FT CDS complement(44771..45214) FT /transl_table=11 FT /gene="rplM" FT /locus_tag="Rv3443c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L13 RPLM" FT /function="INVOLVED IN TRANSLATION MECHANISM. THIS PROTEIN FT IS ONE OF THE EARLY ASSEMBLY PROTEINS OF THE 50S RIBOSOMAL FT SUBUNIT." FT /note="Rv3443c, (MTCY77.15c), len: 147 aa. Probable rplM, FT 50S ribosomal protein L13, equivalent to FT P38014|RL13_MYCLE|RPLM|ML0364|B229_C3_232 from FT Mycobacterium leprae (147 aa), FASTA scores: opt: 917, E(): FT 7.5e-53, (91.15% identity in 147 aa overlap). Also highly FT similar to others e.g. Q53874|RL13_STRCO|RPLM|SC6G4.12 from FT Streptomyces coelicolor (147 aa), FASTA scores: opt: 668, FT E(): 1.1e-36, (65.5% identity in 145 aa overlap); FT Q9X1G5|RL13_THEMA|RPLM|TM1454 from Thermotoga maritima (149 FT aa), FASTA scores: opt: 536, E(): 4.4e-28, (53.65% identity FT in 136 aa overlap); O67722|RL13_AQUAE|RPLM|AQ_1877 from FT Aquifex aeolicus (144 aa), FASTA scores: opt: 529, E(): FT 1.2e-27, (53.2% identity in 141 aa overlap); etc. BELONGS FT TO THE L13P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66065" FT /db_xref="InterPro:IPR005822" FT /db_xref="InterPro:IPR005823" FT /db_xref="UniProtKB/Swiss-Prot:P66065" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08692.1" FT /translation="MPTYAPKAGDTTRSWYVIDATDVVLGRLAVAAANLLRGKHKPTFA FT PNVDGGDFVIVINADKVAISGDKLQHKMVYRHSGYPGGLHKRTIGELMQRHPDRVVEKA FT ILGMLPKNRLSRQIQRKLRVYAGPEHPHSAQQPVPYELKQVAQ" FT CDS complement(45448..45750) FT /transl_table=11 FT /gene="esxT" FT /locus_tag="Rv3444c" FT /product="PUTATIVE ESAT-6 LIKE PROTEIN ESXT" FT /function="UNKNOWN" FT /note="Rv3444c, (MTCY77.16c), len: 100 aa. esxT, ESAT-6 FT like protein (see citation below), equivalent to FT Q9CCV7|ML0363 POSSIBLE SECRETED PROTEIN from Mycobacterium FT leprae (104 aa), FASTA scores: opt: 362, E(): 1.1e-18, FT (71.25% identity in 73 aa overlap). C-terminal part highly FT similar to Q49852|B229_C1_150 HYPOTHETICAL 5.3 KDA PROTEIN FT from Mycobacterium leprae (49 aa), FASTA scores: opt: 227, FT E(): 1.4e-09, (68.9% identity in 45 aa overlap). SEEMS TO FT BELONG TO THE ESAT6 FAMILY." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/TrEMBL:O06261" FT /protein_id="CAB08674.1" FT /translation="MNADPVLSYNFDAIEYSVRQEIHTTAARFNAALQELRSQIAPLQQ FT LWTREAAAAYHAEQLKWHQAASALNEILIDLGNAVRHGADDVAHADRRAAGAWAR" FT CDS complement(45771..46148) FT /transl_table=11 FT /gene="esxU" FT /locus_tag="Rv3445c" FT /product="ESAT-6 LIKE PROTEIN ESXU" FT /function="UNKNOWN" FT /note="Rv3445c, (MTCY77.17c), len: 125 aa. esxU, ESAT-6 FT like protein (see citations below), showing weak similarity FT to O30373|VCD|PA2257 PYOVERDINE BIOSYNTHESIS PROTEIN from FT Pseudomonas aeruginosa (215 aa), FASTA scores: opt: 103, FT E(): 5.6, (32.35% identity in 133 aa overlap). SEEMS TO FT BELONG TO THE ESAT6 FAMILY." FT /db_xref="UniProtKB/TrEMBL:O06262" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08675.1" FT /translation="MVEPGRIGGNQTRLAAVLLDVSTPNTLNADFDLMRSVAGITDARN FT EEIRAMLQAFIGRMSGVPPSVWGGLAAARFQDVVDRWNAESTRLYHVLHAIADTIRHNE FT AALREAGQIHARHIAAAGGDL" FT CDS complement(46141..47355) FT /transl_table=11 FT /locus_tag="Rv3446c" FT /product="HYPOTHETICAL ALANINE AND VALINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical FT unknown ala-, val-rich protein." FT /db_xref="UniProtKB/TrEMBL:O06263" FT /protein_id="CAB08676.1" FT /translation="MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALL FT DERPVAVDSLWFDALRSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRS FT WLLRQASSGVSAATVVVEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGIT FT AVVLIDVPSTVAGAAALAAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAA FT RPATRSRVPTLARVAAAGVALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWS FT TQRVVSGPGSARVQVTSPADPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDF FT NPSDIRAGRPAVTYREVRAGHQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRS FT VHAVG" FT CDS complement(47352..51062) FT /transl_table=11 FT /locus_tag="Rv3447c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN, BUT COULD HYDDROLYSE ATP/GTP." FT /note="Rv3447c, (MTCY77.19c), len: 1236 aa. Probable FT conserved membrane protein, similar to various bacterial FT proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from FT Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, FT E(): 1.9e-60, (42.9% identity in 1312 aa overlap); FT Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa), FT FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in FT 1374 aa overlap); Q9CD30|ML2535 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (1329 aa), FASTA scores: opt: 910, FT E(): 1.5e-44, (34.4% identity in 1319 aa overlap); FT Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans FT (1489 aa), FASTA scores: opt: 805, E(): 1.9e-38, (25.85% FT identity in 1292 aa overlap); etc. The C-terminal region is FT similar to Q9CDD7|ML0052 (alias O33086|MLCB628.15c) FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FT FASTA scores: opt: 850, E(): 2.3e-41, (35.2% identity in FT 588 aa overlap); and O6973|Rv3871|MTV027.06 HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (591 aa), FASTA FT scores: opt: 845, E(): 4.3e-41, (35.3% identity in 586 aa FT overlap). N-terminal part shows similarity with FT HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. FT O69735|Rv3870|MTV027.05 (747 aa), FASTA scores: opt: 761, FT E(): 3.6e-36, (38.2% identity in 746 aa overlap). FT Equivalent to AAK47893 from Mycobacterium tuberculosis FT strain CDC1551 (1200 aa) but longer 36 aa. Contains three FT of PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:O06264" FT /db_xref="InterPro:IPR002543" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:O06264" FT /protein_id="CAB08677.1" FT /translation="MNSGPACATADILVAPPPELRRSEPSSLLIRLLPVVMSVATVGVM FT VTVFLPGSPATRHPTFLAFPMMMLVSLVVTAVTGRGRRHVSGIHNDRVDYLGYLSVLRT FT SVTQTAAAQHVSLNWTHPDPATLWTLIGGPRMWERRPGAADFCRIRVGVGSAPLATRLV FT VGQLPPAQRADPVTRAALRCFLAAHATIADAPIAIPLRVGGPIAIDGDPTKVRGLLRAM FT ICQLAVWHSPEELLIAGVVSDRNRAHWDWLKWLPHNQHPNACDALGPAPMVYSTLAEMQ FT NALAATVLAHVVAIVDTAERGNGAITGVITIEVGARRDGAPPVVRCAGEVTALACPDQL FT EPQDALVCARRLAAHRVGHSGRTFIRGSGWAELVGIGDVAAFDPSTLWRNVNQHDRLRV FT PIGVTPDGTAVQLDIKEAAEQGMGPHGLCVGATGSGKSELLRTIALGMMARNSPEVLNL FT LLVDFKGGATFLDLAGAPHVAAVITNLAEEAPLVARMQDALAGEMSRRQQLLRMAGHLV FT SVTAYQRARQTGAQLPCLPILFIVVDEFSELLSQHPEFVDVFLAIGRVGRSLGMHLLLA FT SQRLDEGRLRGLETHLSYRMCLKTWSASESRNVLGTQDAYQLPNTPGAGLLQTGTGELI FT RFQTAFVSGPLRRASPSAVHPVAPPSVRPFTTHAAAPVTAGPVGGTAEVPTPTVLHAVL FT DRLVGHGPAAHQVWLPPLDEPPMLGALLRDAEPAQAELAVPIGIVDRPFEQSRVPLTID FT LSGAAGNVAVVGAPQTGKSTALRTLIMALAATHDAGRVQFYCLDFGGGALAQVDELPHV FT GAVAGRAQPQLASRMLAELESAVRFREAFFRDHGIDSVARYRQLRAKSAAESFADIFLV FT IDGWASLRQEFAALEESIVALAAQGLSFGVHVALSAARWAEIRPSLRDQIGSRIELRLA FT DPADSELDRRQAQRVPVDRPGRGLSRDGMHMVIALPDLDGVALRRRSGDPVAPPIPLLP FT ARVDYDSVVARAGDELGAHILLGLEERRGQPVAVDFGRHPHLLVLGDNECGKTAALRTL FT CREIVRTHTAARAQLLIVDFRHTLLDVIESEHMSGYVSSPAALGAKLSSLVDLLQARMP FT APDVSQAQLRARSWWSGPDIYVVVDDYDLVAVSSGNPLMVLLEYLPHARDLGLHLVVAR FT RSGGAARALFEPVLASLRDLGCRALLMSGRPDEGALFGSSRPMPLPPGRGILVTGAGDE FT QLVQVAWSPPP" FT misc_feature complement(47937..47960) FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature complement(48747..48770) FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature complement(49752..49775) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 51176..52579 FT /transl_table=11 FT /locus_tag="Rv3448" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN. POSSIBLY INVOLVED IN TRANSPORT ACROSS FT THE MEMBRANE." FT /note="Rv3448, (MTCY77.20), len: 467 aa. Probable conserved FT integral membrane protein, showing some similarity with FT Q9CD35|ML2529 from Mycobacterium leprae (485 aa), FASTA FT scores: opt: 371, E(): 3.6e-14, (27.25% identity in 481 aa FT overlap); and two proteins from Mycobacterium tuberculosis FT O86362|Rv0290|MTV035.18 (472 aa), FASTA scores: opt: 429, FT E(): 1.6e-17, (28.6% identity in 479 aa overlap); and FT O05457|Rv3887c|MTCY15F10.25 (509 aa), FASTA scores: opt: FT 203, E(): 0.00019, (25.6% identity in 492 aa overlap). FT Contains PS00402 Binding-protein-dependent transport FT systems inner membrane comp signature." FT /db_xref="InterPro:IPR006707" FT /db_xref="UniProtKB/TrEMBL:O33354" FT /protein_id="CAB08736.1" FT /translation="MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRG FT ASPATAARYQLSALGAPALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAA FT ALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAGLA FT ALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVL FT AMRITGCGGITLTAVACCAVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMAV FT LLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLTSLLAAFAASATIGAIGTAVA FT THGIHRSSMGGIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEH FT GPWIAALTAMLAAVAMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSA FT VRHLDLTWT" FT misc_feature 51176..51262 FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp signature" FT CDS 52576..53943 FT /transl_table=11 FT /gene="mycP4" FT /locus_tag="Rv3449" FT /product="PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP4 (SERINE FT PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) FT (MYCOSIN-4)" FT /function="THOUGHT TO HAVE PROTEOLYTIC ACTIVITY." FT /EC_number="3.4.21.-" FT /note="Rv3449, (MTCY13E12.02), len: 455 aa. Probable mycP4, FT membrane-anchored serine protease (mycosin) (EC 3.4.21.-) FT (see citation below), similar to hypothetical unknowns or FT proteases from Mycobacterium tuberculosis strains H37Rv and FT CDC1551 e.g. AAK48366|MT3998 SUBTILASE FAMILY PROTEIN from FT Mycobacterium tuberculosis strain CDC1551 (411 aa), FASTA FT scores: opt: 747, E(): 3.5e-33, (45.65% identity in 416 aa FT overlap); O05461|Rv3883c|MTCY15F10.29 MEMBRANE-ANCHORED FT MYCOSIN MYCP1 (446 aa), FASTA scores: opt: 747, E(): FT 3.8e-33, (45.45% identity in 451 aa overlap); FT O53695|Rv0291|MTV035.19 PROBABLE MEMBRANE-ANCHORED MYCOSIN FT MYCP2 (461 aa), FASTA scores: opt: 660, E(): 1.9e-28, FT (44.0% identity in 457 aa overlap); etc. And similar to FT hypothetical proteases from Mycobacterium leprae e.g. FT O33076|MLCB628.04|ML0041 HYPOTHETICAL 45.7 KDA PROTEIN FT (PROBABLE SECRETED PROTEASE) (446 aa), FASTA scores: opt: FT 683, E(): 1.1e-29, (43.8% identity in 450 aa overlap); FT Q9CD36|ML2528 PUTATIVE PROTEASE (475 aa), FASTA scores: FT opt: 608, E(): 1.3e-25, (43.0% identity in 451 aa overlap); FT Q9CBV3|ML1538 POSSIBLE PROTEASE (567 aa), FASTA scores: FT opt: 389, E(): 9.7e-14, (33.8% identity in 562 aa overlap); FT etc. Also some similarity to other proteases from several FT organisms e.g. O31788|APRX ALKALINE SERINE PROTEASE from FT Bacillus subtilis (442 aa), FASTA scores: opt: 296, E(): FT 8.3e-09, (29.4% identity in 313 aa overlap); FT O86650|SC3C3.17c PUTATIVE SECRETED SERINE PROTEASE from FT Streptomyces coelicolor (450 aa), FASTA scores: opt: 279, FT E(): 7e-08, (33.55% identity in 343 aa overlap); FT Q9KBJ7|APRX|BH193 INTRACELLULAR ALKALINE SERINE PROTEASE FT from Bacillus halodurans (444 aa), FASTA scores: opt: 257, FT E(): 1.1e-06, (28.65% identity in 335 aa overlap); FT O86642|SC3C3.08 SERINE PROTEASE from Streptomyces FT coelicolor (413 aa), FASTA scores: opt: 243, E(): 5.7e-06, FT (38.25% identity in 387 aa overlap); etc. Has putative FT signal peptide at N-terminus and hydrophobic stretch at FT C-terminus. Contains three signatures typical of subtilase FT family: aspartic acid active site (PS00136), histidine FT active site (PS00137), and serine active site (PS00138). FT BELONGS TO PEPTIDASE FAMILY S8 (ALSO KNOWN AS THE SUBTILASE FT FAMILY), PYROLYSIN SUBFAMILY." FT /db_xref="GOA:O06316" FT /db_xref="HSSP:1AVT" FT /db_xref="HSSP:1BH6" FT /db_xref="InterPro:IPR000209" FT /db_xref="InterPro:IPR015500" FT /db_xref="UniProtKB/TrEMBL:O06316" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08735.1" FT /translation="MTTSRTLRLLVVSALATLSGLGTPVAHAVSPPPIDERWLPESALP FT APPRPTVQREVCTEVTAESGRAFGRAERSAQLADLDQVWRLTRGAGQRVAVIDTGVARH FT RRLPKVVAGGDYVFTGDGTADCDAHGTLVAGIIAAAPDAQSDNFSGVAPDVTLISIRQS FT SSKFAPVGDPSSTGVGDVDTMAKAVRTAADLGASVINISSIACVPAAAAPDDRALGAAL FT AYAVDVKNAVIVAAAGNTGGAAQCPPQAPGVTRDSVTVAVSPAWYDDYVLTVGSVNAQG FT EPSAFTLAGPWVDVAATGEAVTSLSPFGDGTVNRLGGQHGSIPISGTSYAAPVVSGLAA FT LIRARFPTLTARQVMQRIESTAHHPPAGWDPLVGNGTVDALAAVSSDSIPQAGTATSDP FT APVAVPVPRRSTPGPSDRRALHTAFAGAAICLLALMATLATASRRLRPGRNGIAGD" FT misc_feature 52855..52887 FT /note="PS00136 Serine proteases, subtilase family, aspartic FT acid active site" FT misc_feature 52960..52992 FT /note="PS00137 Serine proteases, subtilase family, FT histidine active site" FT misc_feature 53554..53586 FT /note="PS00138 Serine proteases, subtilase family, serine FT active site" FT CDS complement(53908..55320) FT /transl_table=11 FT /locus_tag="Rv3450c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3450c, (MTCY13E12.03c), len: 470 aa. Probable FT conserved membrane protein (possible membrane spanning FT region near N-terminus). Similar to hypothetical unknowns FT proteins from Mycobacterium leprae e.g. FT O33088|MLCB628.17C|ML0054 HYPOTHETICAL 51.9 KDA PROTEIN FT (PUTATIVE MEMBRANE PROTEIN)(481 aa), FASTA scores: opt: FT 708, E(): 6.4e-32, (32.9% identity in 480 aa overlap); FT Q9CD29|ML2536 (552 aa), FASTA scores: opt: 394, E(): FT 1.7e-14, (33.6% identity in 503 aa overlap); etc. Also FT similar to other proteins from Mycobacterium tuberculosis FT (strains H37Rv and CDC1551) e.g. O69734|Rv3869|MTV027.04 FT (480 aa), FASTA scores: opt: 717, E(): 2e-32, (32.55% FT identity in 479 aa overlap); O05449|Rv3895c|MTCY15F10.17 FT (495 aa), FASTA scores: opt: 670, E(): 8.3e-30, (36.4% FT identity in 475 aa overlap); O5368|Rv0283|MTV035.11 (538 FT aa), FASTA scores: opt: 467, E(): 1.5e-18, (36.3% identity FT in 493 aa overlap); etc." FT /db_xref="InterPro:IPR007795" FT /db_xref="UniProtKB/TrEMBL:O06317" FT /protein_id="CAB08716.1" FT /translation="MPSPATTWLHVSGYRFLLRRIECALLFGDVCAATGALRARTTSLA FT LGCVLAIVAAMGCAFVALLRPQSALGQAPIVMGRESGALYVRVDDVWHPVLNLASARLI FT AATNANPQPVSESELGHTKRGPLLGIPGAPQLLDQPLAGAESAWAICDSDNGGSTTVVV FT GPAEDSSAQVLTAEQMILVATESGSPTYLLYGGRRAVVDLADPAVVWALRLQGRVPHVV FT AQSLLNAVPEAPRITAPRIRGGGRASVGLPGFLVGGVVRITRASGDEYYVVLEDGVQRI FT GQVAADLLRFGDSQGSVNVPTVAPDVIRVAPIVNTLPVSAFPDRPPTPVDGSPGRAVTT FT LCVTWTPAQPGAARVAFLAGSGPPVPLGGVPVTLAQADGRGPALDAVYLPPGRSAYVAA FT RSLSGGGTGTRYLVTDTGVRFAIHDDDVAHDLGLPTAAIPAPWPVLATLPSGPELSRAN FT ASVARDTVAPGP" FT misc_feature complement(55147..55179) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 55441..56229 FT /transl_table=11 FT /gene="cut3" FT /locus_tag="Rv3451" FT /product="PROBABLE CUTINASE PRECURSOR CUT3" FT /function="HYDROLYSIS OF CUTIN (A POLYESTER THAT FORMS THE FT STRUCTURE OF PLANT CUTICLE)." FT /EC_number="3.1.1.-" FT /note="Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3, FT cutinase precursor (EC 3.1.1.-), similar to others e.g. FT Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: FT opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); FT Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia FT fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05, FT (31.45% identity in 210 aa overlap); Q9Y7G8 from FT Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203, FT E(): 8.5e-05, (31.05% identity in 190 aa overlap); FT P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA FT scores: opt: 155, E(): 0.054, (31.65% identity in 120 aa FT overlap). Similar to other proteins from Mycobacterium FT tuberculosis e.g. the downstream ORF FT O06319|Rv3452|MTCY13E12.05 HYPOTHETICAL 23.1 KDA PROTEIN FT (226 aa), FASTA scores: opt: 775, E(): 1e-37, (58.65% FT identity in 220 aa overlap); FT Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE FT CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 565, E(): FT 1.3e-25, (44.85% identity in 223 aa overlap); FT Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 PROBABLE FT CUTINASE PRECURSOR (217 aa), FASTA scores: opt: 489, E(): FT 3e-21, (47.05% identity in 221 aa overlap); etc. Equivalent FT to AAK47897 from Mycobacterium tuberculosis strain CDC1551 FT (247 aa) but longer 15 aa. Contains cutinase, serine active FT site motif (PS00155). BELONGS TO THE CUTINASE FAMILY. FT Alternative start possible at 3733. Start changed since FT first submission (+15 aa)." FT /db_xref="GOA:P0A536" FT /db_xref="InterPro:IPR000675" FT /db_xref="InterPro:IPR011150" FT /db_xref="UniProtKB/Swiss-Prot:P0A536" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08717.2" FT /translation="MNNRPIRLLTSGRAGLGAGALITAVVLLIALGAVWTPVAFADGCP FT DAEVTFARGTGEPPGIGRVGQAFVDSLRQQTGMEIGVYPVNYAASRLQLHGGDGANDAI FT SHIKSMASSCPNTKLVLGGYSQGATVIDIVAGVPLGSISFGSPLPAAYADNVAAVAVFG FT NPSNRAGGSLSSLSPLFGSKAIDLCNPTDPICHVGPGNEFSGHIDGYIPTYTTQAASFV FT VQRLRAGSVPHLPGSVPQLPGSVLQMPGTAAPAPESLHGR" FT misc_feature 55804..55821 FT /note="PS00155 Cutinase, serine active site, GGYSQG" FT CDS 56276..56956 FT /transl_table=11 FT /gene="cut4" FT /locus_tag="Rv3452" FT /product="PROBABLE CUTINASE PRECURSOR CUT4" FT /function="HYDROLYSIS OF CUTIN (A POLYESTER THAT FORMS THE FT STRUCTURE OF PLANT CUTICLE)." FT /EC_number="3.1.1.-" FT /note="Rv3452, (MTCY13E12.05), len: 226 aa. Probable cut4, FT cutinase precursor (EC 3.1.1.-), similar to other e.g. FT Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: FT opt: 522, E(): 7.3e-24, (46.6% identity in 221 aa overlap); FT P30272|CUTI_MAGGR|CUT1 from Magnaporthe grisea (Rice blast FT fungus) (Pyricularia grisea) (228 aa), FASTA scores: opt: FT 205, E(): 3.8e-05, (29.25% identity in 164 aa overlap); FT Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia FT fuckeliana) (202 aa), FASTA scores: opt: 204, E(): 3.9e-05, FT (33.5% identity in 209 aa overlap); etc. Similar to other FT proteins from Mycobacterium tuberculosis e.g. upstream ORF FT O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE FT CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 773, E(): FT 1.3e-38, (59.35% identity in 209 aa overlap); FT Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE FT CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 704, E(): FT 1.3e-34, (53.4% identity in 219 aa overlap); etc. Contains FT PS00155 Cutinase, serine active site. BELONGS TO THE FT CUTINASE FAMILY. Alternative start possible at 4553 in FT cSCY13E12 but no RBS." FT /db_xref="GOA:O06319" FT /db_xref="HSSP:1QOZ" FT /db_xref="InterPro:IPR000675" FT /db_xref="UniProtKB/TrEMBL:O06319" FT /protein_id="CAB08718.1" FT /translation="MIPRPQPHSGRWRAGAARRLTSLVAAAFAAATLLLTPALAPPASA FT GCPDAEVVFARGTGEPPGLGRVGQAFVSSLRQQTNKSIGTYGVNYPANGDFLAAADGAN FT DASDHIQQMASACRATRLVLGGYSQGAAVIDIVTAAPLPGLGFTQPLPPAADDHIAAIA FT LFGNPSGRAGGLMSALTPQFGSKTINLCNNGDPICSDGNRWRAHLGYVPGMTNQAARFV FT ASRI" FT misc_feature 56648..56665 FT /note="PS00155 Cutinase, serine active site, GGYSQG" FT CDS 57228..57560 FT /transl_table=11 FT /locus_tag="Rv3453" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3453, (MTCY13E12.06), len: 110 aa. Possible FT conserved transmembrane protein, showing weak similarity FT with other proteins e.g. Q9F6C3 PUTATIVE ABC TRANSPORTER FT from Propionibacterium thoenii (424 aa), FASTA scores: opt: FT 104, E(): 6.8, (40.6% identity in 69 aa overlap)." FT /db_xref="GOA:O06320" FT /db_xref="UniProtKB/TrEMBL:O06320" FT /protein_id="CAB08719.1" FT /translation="MPGVITNSESPTAADHDRITATRETLEDYTLRLAPRSYRRWPPAV FT VGISALGGIAYLADFAIGANVGITWGTANALCGIAIFALVVFVTGLPLAYYAARYNIDL FT DLIYPR" FT CDS 57646..58914 FT /transl_table=11 FT /locus_tag="Rv3454" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3454, (MTCY13E12.07), len: 422 aa. Probable FT conserved integral membrane protein, showing some FT similarity to various proteins (generally transporters) FT e.g. Q9I5C8|PA0811 PROBABLE MFS TRANSPORTER from FT Pseudomonas aeruginosa (415 aa), FASTA scores: opt: 145, FT E(): 0.13, (28.2% identity in 188 aa overlap); FT Q01266|YHYC_PSESN HYPOTHETICAL PROTEIN IN HYUC 3'REGION FT (ORF 5) (FRAGMENT) from Pseudomonas sp. strain NS671 (245 FT aa), FASTA scores: opt: 130, E(): 0.75, (24.65% identity in FT 134 aa overlap); Q9I242|PA2073 PROBABLE TRANSPORTER FT (MEMBRANE SUBUNIT) from Pseudomonas aeruginosa (476 aa), FT FASTA scores: opt: 125, E(): 2.5, (24.6% identity in 252 aa FT overlap); etc. Equivalent to AAK47900 from Mycobacterium FT tuberculosis strain CDC1551 (562 aa) but shorter 140 aa. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="UniProtKB/TrEMBL:O06321" FT /protein_id="CAB08720.1" FT /translation="MAQGLKLGLHIPLWAGYACSTLIIFPLVVYGMKVLSQLQLWTTPL FT WLILMAAPFGYLVVSHPDSIGQFFSYAGKDGHGGLSFGSVLLAAGVCLSLIAQIAEQID FT YLRFMPPRTPENANRWWTWTLLAGPGWVAFGATKQIIGLFLAVYLMANIPGSSTIANQP FT VHQFMQIYRTFVPGWLALTLAVILVVLSQIKINVTNAYSGSLAWTNSFTRLTKHYPGRV FT VFLGVNLAIALILMEANMFDFLNTILGCYANCGMAWVVAVASDIGFNKYLLGLSPKTPE FT FRRGMLYAINPVGFGSLLLAAGLSIVTFFGGLGAALQPYSPLVAIVTALVMPPILAAAT FT KGKYYLRRTHDGIDLPMYDEHGNPSAAVLTCHVCHQDFERPDMLACQTHGAHVCSLCLS FT TDKQAEHVLPGLARAHIPGDQVP" FT misc_feature 57670..57702 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(58876..59646) FT /transl_table=11 FT /gene="truA" FT /locus_tag="Rv3455c" FT /product="PROBABLE TRNA PSEUDOURIDINE SYNTHASE A TRUA FT (PSEUDOURIDYLATE SYNTHASE I) (PSEUDOURIDINE SYNTHASE I) FT (URACIL HYDROLYASE)" FT /function="FORMATION OF PSEUDOURIDINE AT POSITIONS 38, 39 FT AND 40 IN THE ANTICODON STEM AND LOOP OF TRANSFER RNAS FT [CATALYTIC ACTIVITY: URACIL + D-RIBOSE 5-PHOSPHATE = FT PSEUDOURIDINE 5'-PHOSPHATE + H(2)O]." FT /EC_number="4.2.1.70" FT /note="Rv3455c, (MTCY13E12.08c), len: 256 aa. Probable FT truA, pseudouridine synthase A (EC 4.2.1.70), equivalent to FT Q9X796|TRUA_MYCLE|ML1955|MLCB1222.25c TRNA PSEUDOURIDINE FT SYNTHASE A from Mycobacterium leprae (249 aa), FASTA FT scores: opt: 1345, E(): 3.2e-80, (77.25% identity in 246 aa FT overlap). Also highly similar to others e.g. FT O86776|TRUA_STRCO|SC6G4.09 from Streptomyces coelicolor FT (284 aa), FASTA scores: opt: 595, E(): 1.7e-31, (49.8% FT identity in 259 aa overlap); Q9RS37|DR2290 from Deinococcus FT radiodurans (280 aa), FASTA scores: opt: 383, E(): 1e-17, FT (41.2% identity in 216 aa overlap); FT Q9PJT0|TRUA_CHLMU|TC0748 from Chlamydia muridarum (267 aa), FT FASTA scores: opt: 334, E(): 1.5e-14, (37.65% identity in FT 231 aa overlap); P07649|TRUA_ECOLI|HIST|ASUC|LEUK|B2318 FT from Escherichia coli strain K12 (270 aa), FASTA scores: FT opt: 315, E(): 2.5e-13, (33.35% identity in 240 aa FT overlap); etc. BELONGS TO THE TRUA FAMILY OF PSEUDOURIDINE FT SYNTHASES." FT /db_xref="GOA:P65846" FT /db_xref="InterPro:IPR001406" FT /db_xref="InterPro:IPR020094" FT /db_xref="InterPro:IPR020095" FT /db_xref="InterPro:IPR020097" FT /db_xref="InterPro:IPR020103" FT /db_xref="UniProtKB/Swiss-Prot:P65846" FT /protein_id="CAB08721.1" FT /translation="MGQRTVAGDLDAALTTIFRTPVRLRAAGRTDAGVHASGQVAHVDV FT PADALPNAYPRAGHVGDPEFLPLLRRLGRFLPADVRILDITRAPAGFDARFSALRRHYV FT YRLSTAPYGVEPQQARYITAWPRELDLDAMTAASRDLMGLHDFAAFCRHREGATTIRDL FT QRLDWSRAGTLVTAHVTADAFCWSMVRSLVGALLAVGEHRRATTWCRELLTATGRSSDF FT AVAPAHGLTLIQVDYPPDDQLASRNLVTRDVRSG" FT CDS complement(59714..60256) FT /transl_table=11 FT /gene="rplQ" FT /locus_tag="Rv3456c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L17 RPLQ" FT /function="INVOLVED IN TRANSLATION MECHANISM." FT /note="Rv3456c, (MTCY13E12.09c), len: 180 aa. Probable FT rplQ, 50S ribosomal protein L17, equivalent to FT Q9X797|RL17_MYCLE|ML1956|MLCB1222.26c 50S RIBOSOMAL PROTEIN FT L17 from Mycobacterium leprae (170 aa), FASTA scores: opt: FT 874, E(): 9.5e-45, (81.85% identity in 171 aa overlap). FT Also highly similar to other e.g. FT O86775|RL17_STRCO|SC6G4.08 from Streptomyces coelicolor FT (168 aa), FASTA scores: opt: 609, E(): 3.7e-29, (60.0% FT identity in 170 aa overlap); BAB47931|MLR0326 from FT Rhizobium loti (Mesorhizobium loti) (143 aa), FASTA scores: FT opt: 404, E(): 3.7e-17, (49.65% identity in 139 aa FT overlap); Q9Z9H5|RL17_THETH|RPLQ from Thermus aquaticus FT (subsp. thermophilus) (118 aa), FASTA scores: opt: 366, FT E(): 5.5e-15, (53.15% identity in 111 aa overlap); FT P02416|RL17_ECOLI|RPLQ|B3294 from Escherichia coli strain FT K12 (127 aa), FASTA scores: opt: 347, E(): 7.6e-14, (50.4% FT identity in 119 aa overlap); etc. BELONGS TO THE L17P FT FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5V4" FT /db_xref="InterPro:IPR000456" FT /db_xref="UniProtKB/Swiss-Prot:P0A5V4" FT /protein_id="CAB08722.1" FT /translation="MPKPTKGPRLGGSSSHQKAILANLATSLFEHGRITTTEPKARALR FT PYAEKLITHAKKGALHNRREVLKKLRDKDVVHTLFAEIGPFFADRDGGYTRIIKIEARK FT GDNAPMAVIELVREKTVTSEANRARRVAAAQAKAKKAAAMPTEESEAKPAEEGDVVGAS FT EPDAKAPEEPPAEAPEN" FT CDS complement(60288..61331) FT /transl_table=11 FT /gene="rpoA" FT /locus_tag="Rv3457c" FT /product="PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA FT CHAIN) RPOA (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE FT ALPHA SUBUNIT) (DNA-DIRECTED RNA NUCLEOTIDYLTRANSFERASE)" FT /function="DNA-DEPENDENT RNA POLYMERASE CATALYZES THE FT TRANSCRIPTION OF DNA INTO RNA USING THE FOUR RIBONUCLEOSIDE FT TRIPHOSPHATES AS SUBSTRATES. THE AMINO-TERMINAL PORTION IS FT INVOLVED IN THE ASSEMBLY OF CORE RNAP, WHEREAS THE FT C-TERMINAL IS INVOLVED IN INTERACTION WITH TRANSCRIPTIONAL FT REGULATORS [CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = FT N PYROPHOSPHATE + RNA(N)]." FT /EC_number="2.7.7.6" FT /note="Rv3457c, (MTCY13E12.10c), len: 347 aa. Probable FT rpoA, alpha chain of RNA polymerase (EC 2.7.7.6), FT equivalent to Q9X798|RPOA_MYCLE|ML1957|MLCB1222.27c FT DNA-DIRECTED RNA POLYMERASE ALPHA from Mycobacterium leprae FT (347 aa), FASTA scores: opt: 2139, E(): 1.3e-123, (95.65% FT identity in 347 aa overlap). Also highly similar to others FT e.g. P72404|RPOA_STRCO|C6G4.07 from Streptomyces coelicolor FT (340 aa), FASTA scores: opt: 1672, E(): 4.7e-95, (75.55% FT identity in 348 aa overlap); Q9X4V6|RPOA_STRGT from FT Streptomyces granaticolor (340 aa), FASTA scores: opt: FT 1671, E(): 5.4e-95, (75.55% identity in 348 aa overlap); FT P20429|RPOA_BACSU from Bacillus subtilis (314 aa), FASTA FT scores: opt: 939, E(): 3e-50, (48.9% identity in 311 aa FT overlap); etc. Contains (PS00017) ATP/GTP-binding site FT motif A (P-loop). BELONGS TO THE RNA POLYMERASE ALPHA CHAIN FT FAMILY." FT /db_xref="GOA:P66701" FT /db_xref="InterPro:IPR009025" FT /db_xref="InterPro:IPR011260" FT /db_xref="InterPro:IPR011261" FT /db_xref="InterPro:IPR011262" FT /db_xref="InterPro:IPR011263" FT /db_xref="InterPro:IPR011773" FT /db_xref="UniProtKB/Swiss-Prot:P66701" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08723.1" FT /translation="MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSS FT IPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQGPGE FT VTAGDIVPPAGVTVHNPGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRIP FT VDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVELFGLA FT RELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTES FT DLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEGAYDEQD FT YAETEQL" FT misc_feature complement(60690..60713) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(61483..62088) FT /transl_table=11 FT /gene="rpsD" FT /locus_tag="Rv3458c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S4 RPSD" FT /function="THIS PROTEIN BINDS DIRECTLY TO 16S RIBOSOMAL FT RNA." FT /note="Rv3458c, (MTCY13E12.11c), len: 201 aa. Probable FT rpsD, 30S ribosomal protein S4, equivalent to FT Q9X799|RS4_MYCLE|RPSD|ML1958|MLCB1222.28c 30S RIBOSOMAL FT PROTEIN S4 from Mycobacterium leprae (201 aa), FASTA FT scores: opt: 1271, E(): 2.2e-73, (93.5% identity in 201 aa FT overlap); and P45811|RS4_MYCBO|RPSD from Mycobacterium FT bovis (131 aa), FASTA scores: opt: 867, E(): 4.9e-48, FT (100.0% identity in 130 aa overlap). Also highly similar to FT others e.g. P81288|RS4_BACST|RPSD from Bacillus FT stearothermophilus (198 aa), FASTA scores: opt: 665, E(): FT 4e-35, (52.25% identity in 201 aa overlap); FT Q9K7Z8|RPSD|BH3209 from Bacillus halodurans (200 aa), FASTA FT scores: opt: 626, E(): 1.2e-32, (48.75% identity in 203 aa FT overlap); Q9X1I3|RS4_THEMA|RPSD|TM1473 from Thermotoga FT maritima (209 aa), FASTA scores: opt: 591, E(): 2e-30, FT (45.0% identity in 209 aa overlap); etc. Contains ribosomal FT protein S4 signature (PS00632) and ATP/GTP binding site FT motif (PS00017). BELONGS TO THE S4P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:O06325" FT /db_xref="InterPro:IPR001912" FT /db_xref="InterPro:IPR002942" FT /db_xref="InterPro:IPR005709" FT /db_xref="InterPro:IPR018079" FT /db_xref="UniProtKB/Swiss-Prot:O06325" FT /protein_id="CAB08724.1" FT /translation="MARYTGPVTRKSRRLRTDLVGGDQAFEKRPYPPGQHGRARIKESE FT YLLQLQEKQKARFTYGVMEKQFRRYYEEAVRQPGKTGEELLKILESRLDNVIYRAGLAR FT TRRMARQLVSHGHFNVNGVHVNVPSYRVSQYDIVDVRDKSLNTVPFQIARETAGERPIP FT SWLQVVGERQRVLIHQLPERAQIDVPLTEQLIVEYYSK" FT misc_feature complement(61750..61824) FT /note="PS00632 Ribosomal protein S4 signature" FT misc_feature complement(61846..61869) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(62097..62516) FT /transl_table=11 FT /gene="rpsK" FT /locus_tag="Rv3459c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK" FT /function="S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF FT THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS. IT IS LOCATED ON FT THE LARGE LOBE OF THE SMALL SUBUNIT." FT /note="Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable FT rpsK, 30S ribosomal protein S11, equivalent to FT Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL FT PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA FT scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa FT overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 FT from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, FT E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also FT highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 FT from Streptomyces coelicolor (134 aa), FASTA scores: opt: FT 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); FT O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 FT aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity FT in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus FT subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, FT (69.0% identity in 129 aa overlap); etc. Contains ribosomal FT protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY FT OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:O06326" FT /db_xref="InterPro:IPR001971" FT /db_xref="InterPro:IPR018102" FT /db_xref="InterPro:IPR019981" FT /db_xref="UniProtKB/Swiss-Prot:O06326" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08725.1" FT /translation="MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTIT FT DPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQDHGVRKVDVFVKGPGSGRE FT TAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV" FT misc_feature complement(62130..62153) FT /note="PS00054 Ribosomal protein S11 signature" FT CDS complement(62520..62894) FT /transl_table=11 FT /gene="rpsM" FT /locus_tag="Rv3460c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S13 RPSM" FT /function="INVOLVED IN THE BINDING OF FMET-TRNA AND, HENCE, FT IN THE INITIATION OF TRANSLATION." FT /note="Rv3460c, (MTCY13E12.13c), len: 124 aa. Probable FT rpsM, 30S ribosomal protein S13, equivalent to FT Q9X7A1|RS13_MYCLE|RPSM|ML1960|MLCB1222.30c 30S RIBOSOMAL FT PROTEIN S13 from Mycobacterium leprae (124 aa), FASTA FT scores: opt: 762, E(): 1.5e-43, (92.75% identity in 124 aa FT overlap); and P45813|RS13_MYCBO|RPSM from Mycobacterium FT bovis (123 aa), FASTA scores: opt: 727, E(): 3e-41, (98.25% FT identity in 114 aa overlap). Also highly similar to others FT e.g. O86773|RS13_STRCO|SC6G4.05 from Streptomyces FT coelicolor (126 aa), FASTA scores: opt: 631, E(): 6.2e-35, FT (73.75% identity in 122 aa overlap); Q9RA65|RPS13 from FT Thermus aquaticus (subsp. thermophilus) (126 aa), FASTA FT scores: opt: 552, E(): 9.8e-30, (62.6% identity in 123 aa FT overlap); P20282|RS13_BACSU|RPSM from Bacillus subtilis FT (120 aa), FASTA scores: opt: 533, E(): 1.7e-28, (64245% FT identity in 121 aa overlap); etc. Contains ribosomal FT protein S13 signature (PS00646). BELONGS TO THE S13P FAMILY FT OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:O06327" FT /db_xref="InterPro:IPR001892" FT /db_xref="InterPro:IPR010979" FT /db_xref="InterPro:IPR018269" FT /db_xref="InterPro:IPR019980" FT /db_xref="UniProtKB/Swiss-Prot:O06327" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08726.1" FT /translation="MARLVGVDLPRDKRMEVALTYIFGIGRTRSNEILAATGIDRDLRT FT RDLTEEQLIHLRDYIEANLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGMPVRGQRTK FT TNARTRKGPKRTIAGKKKAR" FT misc_feature complement(62592..62633) FT /note="PS00646 Ribosomal protein S13 signature" FT CDS complement(63110..63223) FT /transl_table=11 FT /gene="rpmJ" FT /locus_tag="Rv3461c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L36 RPMJ" FT /function="INVOLVED IN TRANSLATION MECHANISM." FT /note="Rv3461c, (MTCY13E12.14c), len: 37 aa. Probable rpmJ, FT 50S ribosomal protein L36, equivalent to FT P45810|RL36_MYCBO|RPMJ from Mycobacterium bovis (37 aa); FT and Q9X7A2|RL36_MYCLE|RPMJ|ML1961|MLCB1222.31c 50S FT RIBOSOMAL PROTEIN L36 from Mycobacterium leprae (37 aa), FT FASTA scores: opt: 241, E(): 9.7e-14, (86.5% identity in 37 FT aa overlap). Also highly similar to others e.g. FT O86772|RL36_STRCO|SC6G4.04 from Streptomyces coelicolor (37 FT aa), FASTA scores: opt: 233, E(): 4.5e-13, (83.8% identity FT in 37 aa overlap); P07841|RL36_BACST|RPMJ from Bacillus FT stearothermophilus (37 aa), FASTA scores: opt: 214, E(): FT 1.6e-11, (72.95% identity in 37 aa overlap); FT P12230|RK36_SPIOL|RPL36 from Spinacia oleracea (Spinach) FT (37 aa), FASTA scores: opt: 211, E(): 2.9e-11, (70.25% FT identity in 37 aa overlap); etc. Contains PS00828 Ribosomal FT protein L36 signature. BELONGS TO THE L36P FAMILY OF FT RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5W6" FT /db_xref="InterPro:IPR000473" FT /db_xref="UniProtKB/Swiss-Prot:P0A5W6" FT /protein_id="CAB08727.1" FT /translation="MKVNPSVKPICDKCRLIRRHGRVMVICSDPRHKQRQG" FT misc_feature complement(63116..63193) FT /note="PS00828 Ribosomal protein L36 signature" FT CDS complement(63256..63477) FT /transl_table=11 FT /gene="infA" FT /locus_tag="Rv3462c" FT /product="PROBABLE TRANSLATION INITIATION FACTOR IF-1 INFA" FT /function="NO SPECIFIC FUNCTION HAS SO FAR BEEN ATTRIBUTED FT TO THIS INITIATION FACTOR; HOWEVER, IT SEEMS TO STIMULATE FT MORE OR LESS ALL THE ACTIVITIES OF THE OTHER TWO INITIATION FT FACTORS, IF-2 AND IF-3." FT /note="Rv3462c, (MTCY13E12.15c), len: 73 aa. Probable infA, FT initiation factor IF-1, equivalent to P45957|ML1962|INFA FT TRANSLATION INITIATION FACTOR IF-1 from Mycobacterium bovis FT (72 aa) and Mycobacterium leprae (72 aa), FASTA scores: FT opt: 472, E(): 6.6e-28, (100.0% identity in 72 aa overlap). FT Also highly similar to others e.g. FT O54209|IF1_STRCO|INFA|SC6G4.03 from Streptomyces coelicolor FT (73 aa), FASTA scores: opt: 424, E(): 2e-24, (84.95% FT identity in 73 aa overlap); O50630|IF1_BACHD|INFA|BH0158 FT from Bacillus halodurans (71 aa), FASTA scores: opt: 388, FT E(): 8.1e-22, (77.8% identity in 72 aa overlap); FT Q9XD14|IF1_LEPIN|INFA from Leptospira interrogans (71 aa), FT FASTA scores: opt: 376, E(): 6e-21, (80.0% identity in 70 FT aa overlap); etc. CONTAINS 1 'S1 MOTIF' DOMAIN. BELONGS TO FT THE IF-1 FAMILY." FT /db_xref="GOA:P0A5H5" FT /db_xref="InterPro:IPR004368" FT /db_xref="InterPro:IPR006196" FT /db_xref="InterPro:IPR012340" FT /db_xref="InterPro:IPR016027" FT /db_xref="UniProtKB/Swiss-Prot:P0A5H5" FT /protein_id="CAB08728.1" FT /translation="MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQHY FT IRILPEDRVVVELSPYDLSRGRIVYRYK" FT CDS 63731..64588 FT /transl_table=11 FT /locus_tag="Rv3463" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3463, (MTCY13E12.16), len: 285 aa. Conserved FT hypothetical protein, similar to Q9RDA2|SCE20.23 FT HYPOTHETICAL 31.4 KDA PROTEIN from Streptomyces coelicolor FT (290 aa), FASTA scores: opt: 770, E(): 2.2e-41, (48.6% FT identity in 247 aa overlap); and Q9X7Y1|SC6A5.35 PUTATIVE FT OXIDOREDUCTASE from Streptomyces coelicolor (341 aa), (see FT BLASTP results), FASTA scores: opt: 119, E(): 2.9, (24.1% FT identity in 274 aa overlap)." FT /db_xref="InterPro:IPR011251" FT /db_xref="InterPro:IPR019922" FT /db_xref="UniProtKB/TrEMBL:O06328" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08729.1" FT /translation="MTNCAAGKPSSGPNLGRFGSFGRGVTPQQATEIEALGYGAVWVGG FT SPPAALSWVEPILQATTTLCVATGIVNIWSAPAQRVAESFHRIEAAYPGRFLLGIGVGH FT AEMISEYRKPYNALVEYLDRLDDYGVPANRRVVAALGPRVLGLSARRSAGAHPYLTTPE FT HTARARELIGPSAFLAPEHKVVLTTDSARARTVGRQALDMYFNLANYRNNWKRLGFTDD FT EVSRPGSDRLVDAVVAYGTPDAIAARLNEHLLAGADHVPIQVLTEDDNLVSALTELAKP FT LRLT" FT CDS 64661..65656 FT /transl_table=11 FT /gene="rmlB" FT /locus_tag="Rv3464" FT /standard_name="rfbB" FT /product="dTDP-GLUCOSE 4,6-DEHYDRATASE RMLB" FT /function="INVOLVED IN DTDP-L-RHAMNOSE BIOSYNTHESIS FT [CATALYTIC ACTIVITY: DTDP-GLUCOSE = FT DTDP-4-DEHYDRO-6-DEOXY-D-GLUCOSE + H(2)O]." FT /EC_number="4.2.1.46" FT /note="Rv3464, (MTCY13E12.17), len: 331 aa. rmlB (alternate FT gene name: rfbB), dTDP-glucose-4,6-dehydratase (EC FT 4.2.1.46) (see citations below), nearly identical to FT Q50556|RMLB rhamnose biosynthesis protein (EC 4.2.1.46) FT from Mycobacterium tuberculosis (329 aa) (previously rfbB, FT now known as rmlB). Equivalent to Q9CBH7|RMLB|ML1964 FT DTDP-GLUCOSE 4,6-DEHYDRATASE (alias Q9X7A3|RMLB PUTATIVE FT DTDP-(GLUCOSE OR RHAMNOSE)-4,6-DEHYDRATASE (331 aa)) from FT Mycobacterium leprae (333 aa), FASTA scores: opt: 1925, FT E(): 1.9e-112, (84.0% identity in 331 aa overlap). Also FT highly similar to others e.g. Q9UZH2|RFBB|PAB0785 from FT Pyrococcus abyssi (333 aa), FASTA scores: opt: 1115, E(): FT 4.2e-62, (51.55% identity in 322 aa overlap); FT O27817|MTH1789 from Methanobacterium thermoautotrophicum FT (336 aa), FASTA scores: opt: 1104, E(): 2.1e-61, (51.65% FT identity in 331 aa overlap); BAB60064|TVG0950610 from FT Thermoplasma volcanium (318 aa), FASTA scores: opt: 1102, FT E(): 2.6e-61, (49.65% identity in 310 aa overlap); etc. FT Also related to P72050|MTCY13D12.18|RV3784 HYPOTHETICAL FT 36.3 KDA PROTEIN (SIMILAR TO GALACTOWALDENASES FROM FT EUKARYOTIC AND PROKARYOTIC ORIGIN) from Mycobacterium FT tuberculosis (326 aa), FASTA scores: E(): 1.4e-26, (33.8% FT identity in 320 aa overlap)." FT /db_xref="GOA:O06329" FT /db_xref="HSSP:1KEP" FT /db_xref="InterPro:IPR001509" FT /db_xref="InterPro:IPR005888" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O06329" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08730.1" FT /translation="MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLA FT DVEDAIRLVQGDITDAELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTI FT LEAVRRHGVRLHHISTDEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVR FT SYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSA FT VRRILDRGRIGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDP FT STLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERGQ" FT CDS 65658..66266 FT /transl_table=11 FT /gene="rmlC" FT /locus_tag="Rv3465" FT /standard_name="rfbC" FT /product="dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC FT (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE FT SYNTHETASE) (THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE FT 3,5-EPIMERASE)" FT /function="INVOLVED IN dTDP-L-RHAMNOSE BIOSYNTHESIS, WITHIN FT THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE FT BIOSYNTHESIS: CONVERSION OF dTDP-4-KETO-6-DEOXY-D-GLUCOSE FT TO DTDP-4-KETO-RHAMNOSE [CATALYTIC ACTIVITY: FT dTDP-4-DEHYDRO-6-DEOXY-D-GLUCOSE = FT dTDP-4-DEHYDRO-6-DEOXY-L-MANNOSE]." FT /EC_number="5.1.3.13" FT /note="Rv3465, (MTCY13E12.18), len: 202 aa. rmlC (alternate FT gene name: rfbC), dTDP-4-dehydrorhamnose 3,5-epimerase (EC FT 5.1.3.13) (see citations below), nearly identical to FT O33170|RMLC RMLC PROTEIN from Mycobacterium tuberculosis FT (203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5% FT identity in 200 aa overlap) (previously known as rfbC). FT Equivalent to Q9X7A4|RMLC|ML1965 PUTATIVE FT DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE from Mycobacterium FT leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64, FT (75.4% identity in 199 aa overlap). Also highly similar to FT others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis (198 FT aa), FASTA scores: opt: 671, E(): 7e-38, (51.3% identity in FT 193 aa overlap); Q9L6C5 from Streptomyces antibioticus (202 FT aa), FASTA scores: opt: 665, E(): 1.8e-37, (49.25% identity FT in 197 aa overlap); P29783|STRM_STRGR from Streptomyces FT griseus (200 aa), FASTA scores: opt: 608, E(): 1.2e-33, FT (49.25% identity in 201 aa overlap); Q54265|STRM from FT Streptomyces glaucescens (200 aa), FASTA scores: opt: 603, FT E(): 2.5e-33, (46.7% identity in 197 aa overlap); etc. Also FT highly similar to Q9S4D4|TYLJ PUTATIVE NDP-HEXOSE FT 3-EPIMERASE from Streptomyces fradiae (205 aa), FASTA FT scores: opt: 625, E(): 8.6e-35, (45.9% identity in 194 aa FT overlap)." FT /db_xref="GOA:O06330" FT /db_xref="InterPro:IPR000888" FT /db_xref="InterPro:IPR011051" FT /db_xref="InterPro:IPR014710" FT /db_xref="PDB:1PM7" FT /db_xref="PDB:1UPI" FT /db_xref="PDB:2IXC" FT /db_xref="UniProtKB/TrEMBL:O06330" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08731.1" FT /translation="MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDV FT RQVNCSVSSAGVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDSVLLD FT DQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNPQREHTICATDPTLAVDWPLVDGA FT APSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGEMRGT" FT CDS 66349..67017 FT /transl_table=11 FT /locus_tag="Rv3466" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3466, (MTCY13E12.19), len: 222 aa. Conserved FT hypothetical ORF in REP13E12 repeat, but extending 5' of FT repeat. Has segment of identity to other REP13E12 ORF's FT e.g. MTCY336.16, MTCI65.15c, MTCY09F9.19, cMTCY251.14c." FT /db_xref="UniProtKB/Swiss-Prot:O06331" FT /protein_id="CAB08732.1" FT /translation="MGSGSRERIVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLEC FT LVRRLPAVGHALINQLDAQASEEELGGTLCCALANRLRITKPDAARRIADAADLGPRRA FT LTGEPLAPQLTATATAQRQGLIGEAHVKVIRALFRPPARRGGCVHPPGRRSRPGRQSRS FT ISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL FT " FT repeat_region 66374..67745 FT /label=REP-8 FT /rpt_type=DIRECT FT /note="REP-8, len: 1372 bp. REP13E12, copies in FT Mycobacterium tuberculosis cosmids: cY336 from 14471 to FT 15821 (approx. 100% identity); cY251 from 11693 to 13109 FT (approx. 100% identity); cI65 from 14515 to 15905 (approx FT 75% identity); cI125 from 27240 to 28597 (approx. 65% FT Identity); cY22G8 from 13352 to 14689 (approx. 65% FT identity); and cY9F9 from 9019 to 10451 (approx. 65% FT identity); also nearly identical to EM_BA :MB35021 U35021 FT Mycobacterium bovis BCG DNA flanking deletion region 3 from FT 56 to 1466." FT CDS 66788..67741 FT /transl_table=11 FT /locus_tag="Rv3467" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3467, (MTCY13E12.20), len: 317 aa. Conserved FT hypothetical ORF in REP13E12 repeat, identical to ORF's FT from other REP13E12 copies e.g. MTCY251.13c, MTCI65.15c, FT MTCY09F9.19, cMTCY336.17. Also identical to Mycobacterium FT bovis Q50655 HYPOTHETICAL 34.6 kDa PROTEIN (317 aa) in FT identical repeat." FT /db_xref="InterPro:IPR003615" FT /db_xref="InterPro:IPR003870" FT /db_xref="UniProtKB/TrEMBL:Q50655" FT /protein_id="CAB08733.1" FT /translation="MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTER FT ARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTPDA FT AAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGKGFT FT GGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFAN FT DRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGH FT TEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDKPD" FT CDS complement(67799..68893) FT /transl_table=11 FT /locus_tag="Rv3468c" FT /standard_name="rmlB3" FT /product="POSSIBLE DTDP-GLUCOSE 4,6-DEHYDRATASE" FT /function="POSSIBLY INVOLVED IN dTDP-L-RHAMNOSE FT BIOSYNTHESIS [CATALYTIC ACTIVITY: dTDP-GLUCOSE = FT dTDP-4-DEHYDRO-6-DEOXY-D-GLUCOSE + H(2)O]." FT /EC_number="4.2.1.46" FT /note="Rv3468c, (MTCY13E12.21c), len: 364 aa. Possible FT dTDP-glucose-4,6-dehydratase (EC 4.2.1.46), but FT experimental study shown that the purified protein didn't FT have dTDP-glucose dehydratase (rmlB) activity (see citation FT below). Similar to others e.g. O08246|MTME from FT Streptomyces argillaceus (331 aa), FASTA scores: opt: 238, FT E(): 1.2e-07, (29.65% identity in 344 aa overlap); FT Q9LFG7|F4P12_220 from Arabidopsis thaliana (Mouse-ear FT cress) (433 aa), FASTA scores: opt: 237, E(): 1.8e-07, FT (27.25% identity in 308 aa overlap); Q9LZI2|F26K9_260 from FT Arabidopsis thaliana (Mouse-ear cress) (445 aa), FASTA FT scores: opt: 225, E(): 1e-06, (25.95% identity in 335 aa FT overlap); etc. Also similar to various enzymes and FT hypothetical unknowns proteins e.g. BAB48655|MLL1234 FT UDP-GLUCOSE 4-EPIMERASE from Rhizobium loti (Mesorhizobium FT loti) (307 aa), FASTA scores: opt: 757, E(): 4.6e-40, FT (43.4% identity in 302 aa overlap). First start taken, FT alternative at 17080 in cSCYY13E12 suggested by similarity. FT Note that previously known as rmlB3 (see citation below)." FT /db_xref="GOA:Q6MWX3" FT /db_xref="InterPro:IPR001509" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q6MWX3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55599.1" FT /translation="MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSG FT HLGEALVRTLRARGADIVSLDSRPSRYTNIVGCVSDRALLRDVMAGVEVVFHAAAHHKP FT QLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAWIDE FT SVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNI FT KANEYACRRVALEDAVDAHLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFA FT RRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQSVHTPL FT SQLVGSKAYAHSSYHRGVFAPARP" FT CDS complement(68897..69907) FT /transl_table=11 FT /gene="mhpE" FT /locus_tag="Rv3469c" FT /product="PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE MHPE FT (HOA)" FT /function="INVOLVED IN AROMATIC HYDROCARBONS DEGRADATION FT [CATALYTIC ACTIVITY: 4-HYDROXY-2-OXOVALERATE = PYRUVATE + FT ACETALDEHYDE]." FT /EC_number="4.1.3.-" FT /note="Rv3469c, (MTCY13E12.22c), len: 336 aa. Probable FT mhpE, 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), FT similar to others (principally from Pseudomonas species) FT e.g. Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor FT (338 aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65% FT identity in 332 aa overlap); Q9X9Q0|NIKB NIKB PROTEIN (see FT Bruntner et al., 1999) from Streptomyces tendae (357 aa), FT FASTA scores: opt: 571, E(): 4.4e-28, (34.5% identity in FT 339 aa overlap); P51014|BPHF_PSES1 from Pseudomonas sp. FT strain KKS102 (352 aa), FASTA scores: opt: 549, E(): FT 9.9e-27, (31.2% identity in 314 aa overlap); FT Q51983|CMTG_PSEPU from Pseudomonas putida (350 aa), FASTA FT scores: opt: 543, E(): 2.3e-26, (30.7% identity in 319 aa FT overlap); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia FT coli strain K12 (337 aa), FASTA scores: opt: 517, E(): FT 9.1e-25, (31.75% identity in 312 aa overlap); etc. Also FT similar to P71867|MTCY03C7.22|Rv3534c HYPOTHETICAL 36.4 KDA FT PROTEIN from Mycobacterium tuberculosis (346 aa), FASTA FT scores: E(): 7.5e-24, (31.9% identity in 310 aa overlap)." FT /db_xref="GOA:O06334" FT /db_xref="InterPro:IPR000891" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:O06334" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08693.1" FT /translation="MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGI FT PYIEIGHGVTIGAAAAQGPAAHTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGD FT YLDFLRICVIATEFELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVR FT IVYVVDTTGTFLPEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDG FT TLMGFGRGAGNCQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEIS FT FGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVGMRA" FT CDS complement(69968..71626) FT /transl_table=11 FT /gene="ilvB2" FT /locus_tag="Rv3470c" FT /product="PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) FT ILVB2 (AHAS) (ACETOHYDROXY-ACID SYNTHASE LARGE SUBUNIT) FT (ALS)" FT /function="INVOLVED IN VALINE AND ISOLEUCINE BIOSYNTHESIS FT (AT THE FIRST STEP) [CATALYTIC ACTIVITY: 2-ACETOLACTATE + FT CO(2) = 2-PYRUVATE]." FT /EC_number="2.2.1.6" FT /note="Rv3470c, (MTCY13E12.23c), len: 552 aa. Probable FT ilvB2, acetolactate synthase large subunit (EC 4.1.3.18), FT similar to others e.g. P73913|ILVG|SLR2088 from FT Synechocystis sp. strain PCC 6803 (621 aa), FASTA scores: FT opt: 779, E(): 4.5e-39, (30.7% identity in 567 aa overlap); FT O78518|ILVB_GUITH from Guillardia theta (Cryptomonas phi) FT (575 aa), FASTA scores: opt: 742, E(): 6.9e-37, (28.8% FT identity in 566 aa overlap); Q59950|ILVX from Spirulina FT platensis (612 aa), FASTA scores: opt: 715, E(): 3e-35, FT (28.45% identity in 569 aa overlap); etc. Contains thiamine FT pyrophosphate enzymes signature (PS00187)." FT /db_xref="GOA:O06335" FT /db_xref="HSSP:1N0H" FT /db_xref="InterPro:IPR000399" FT /db_xref="InterPro:IPR011766" FT /db_xref="InterPro:IPR012000" FT /db_xref="InterPro:IPR012001" FT /db_xref="UniProtKB/TrEMBL:O06335" FT /protein_id="CAB08694.1" FT /translation="MTVGDHLVARMRAAGISVVCGLPTSRLDSLLVRLSRDAGFQIVLA FT RHEGGAGYLADGFARASGKSAAVFVAGPGATNVISAVANASVNQVPMLILTGEVAVGEF FT GLHSQQDTSDDGLGLGATFRRFCRCSVSIESIANARSKIDSAFRALASIPRGPVHIALP FT RDLVDERLPAHQLGTAAAGLGGLRTLAPCGPDVADEVIGRLDRSRAPMLVLGNGCRLDG FT IGEQIVAFCEKAGLPFATTPNGRGIVAETHPLSLGVLGIFGDGRADEYLFDTPCDLLIA FT VGVSFGGLVTRSFSPRWRGLKADVVHVDPDPSAVGRFVATSLGITTSGRAFVNALNCGR FT PPRFCRRVGVRPPAPAALPGTPQARGESIHPLELMHELDRELAPNATICADVGTCISWT FT FRGIPVRRPGRFFATVDFSPMGCGIAGAIGVALARPEEHVICIAGDGAFLMHGTEISTA FT VAHGIRVTWAVLNDGQMSASAGPVSGRMDPSPVARIGANDLAAMARALGAEGIRVDTRC FT ELRAGVQKALAATGPCVLDIAIDPEINKPDIGLGR" FT misc_feature complement(70286..70345) FT /note="PS00187 Thiamine pyrophosphate enzymes signature" FT CDS complement(71632..72165) FT /transl_table=11 FT /locus_tag="Rv3471c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3471c, (MTCY13E12.24c), len: 177 aa. Conserved FT hypothetical protein, similar to Q59013|MJ1618 HYPOTHETICAL FT PROTEIN from Methanococcus jannaschii (125 aa), FASTA FT scores: opt: 262, E(): 1.2e-09, (39.05% identity in 105 aa FT overlap); and O26452|MTH352 CONSERVED PROTEIN from FT Methanobacterium thermoautotrophicum (131 aa), FASTA FT scores: opt: 222, E(): 3.8e-07, (35.05% identity in 117 aa FT overlap). Equivalent to AAK47934 from Mycobacterium FT tuberculosis strain CDC1551 (184 aa) but shorter 7 aa." FT /db_xref="GOA:O06336" FT /db_xref="InterPro:IPR006045" FT /db_xref="InterPro:IPR011051" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:O06336" FT /protein_id="CAB08695.1" FT /translation="MSTRPERERASTSTDAVLQATVALSAGHKPAFRGFVKDPPRARAH FT AAAMFVSNAREAEPFVAPDLSEIRVLVDRATVGVASVSLAHATVAAGAETVWHRLQATD FT EIYFVLSGRGLVSVGDESGEVGPGDAVWIPAGVPQKIRALGSVPLTFLCACGPAYLPER FT DQRMGEAAVIGAWP" FT CDS 72186..72692 FT /transl_table=11 FT /locus_tag="Rv3472" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3472, (MTCY13E12.25), len: 168 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins e.g. Q9ZAT9|DPSH DAUNORUBICIN BIOSYNTHESIS ENZYME FT from Streptomyces peucetius (194 aa), FASTA scores: opt: FT 181, E(): 6.8e-05, (30.7% identity in 127 aa overlap); FT Q53879 DAUH/E from Streptomyces sp. C5 (151 aa), FASTA FT scores: opt: 168, E(): 0.00038, (29.25% identity in 127 aa FT overlap); and Q9L4U3|AKNV from Streptomyces galilaeus (144 FT aa), FASTA scores: opt: 122, E(): 0.36, (31.25% identity in FT 129 aa overlap)." FT /db_xref="InterPro:IPR011944" FT /db_xref="PDB:2CHC" FT /db_xref="UniProtKB/TrEMBL:O06337" FT /protein_id="CAB08696.1" FT /translation="MRPVDEQWIEILRIQALCARYCLTIDTQDGEGWAGCFTEDGAFEF FT DGWVIRGRPALREYADAHARVVRGRHLTTDLLYEVDGDVATGRSASVVTLATAAGYKIL FT GSGEYQDRLIKQDGQWRIAYRRLRNDRLVSDPSVAVNVADADVAAVVGHLLAAARRLGT FT QMSDT" FT CDS complement(72772..73557) FT /transl_table=11 FT /gene="bpoA" FT /locus_tag="Rv3473c" FT /product="POSSIBLE PEROXIDASE BPOA (NON-HAEM PEROXIDASE)" FT /function="SUPPOSED INVOLVED IN DETOXIFICATION REACTIONS." FT /EC_number="1.11.1.-" FT /note="Rv3473c, (MTCY13E12.26c), len: 261 aa. Possible FT bpoA, peroxidase (non-haem peroxidase) (EC 1.11.1.-), FT similar to various enzymes or hypothetical unknown proteins FT e.g. O85849 HYPOTHETICAL 26.2 KDA PROTEIN from Sphingomonas FT aromaticivorans (247 aa), FASTA scores: opt: 684, E(): FT 4.9e-34, (43.8% identity in 242 aa overlap); FT AAK45412|MT1155 HYDROLASE, ALPHA/BETA HYDROLASE FOLD FAMILY FT from Mycobacterium tuberculosis strain CDC1551 (311 aa), FT FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 FT aa overlap); Q9K3V0|SCD10.27 PUTATIVE HYDROLASE from FT Streptomyces coelicolor (352 aa), FASTA scores: opt: 248, FT E(): 9.7e-08, (26.05% identity in 261 aa overlap); FT P29715|BPA2_STRAU|BPOA2 NON-HAEM BROMOPEROXIDASE (EC FT 1.11.1.-) (BROMIDE PEROXIDASE) (277 aa), FASTA scores: opt: FT 237, E(): 3.6e-07, (29.45% identity in 265 aa overlap); FT O31168|PRXC_STRAU|CPO|CPOT NON-HEME CHLOROPEROXIDASE (EC FT 1.11.1.10) (278 aa), FASTA scores: opt: 236, E(): 4.2e-07, FT (29.45% identity in 265 aa overlap); AAK62388|T5L19.180 FT LIPASE-LIKE PROTEIN from Arabidopsis thaliana (Mouse-ear FT cress) (350 aa), FASTA scores: opt: 236, E(): 5.1e-07, FT (26.65% identity in 274 aa overlap); etc. Also similar to FT O06575|BPOB|Rv1123c|MTCY22G8.12c HYPOTHETICAL 32.5 KDA FT PROTEIN from Mycobacterium tuberculosis (302 aa), FASTA FT scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa FT overlap). Equivalent to AAK47936 from Mycobacterium FT tuberculosis strain CDC1551 (294 aa) but shorter 33 aa. May FT have been inactivated or truncated by neighbouring IS6110." FT /db_xref="GOA:O06338" FT /db_xref="InterPro:IPR000073" FT /db_xref="InterPro:IPR000639" FT /db_xref="UniProtKB/TrEMBL:O06338" FT /protein_id="CAB08697.1" FT /translation="MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEG FT DYRLVSFAGDIQEVLRNLPGQPALVGASLGGFAAMLLAGELSPGIASAVVLVDIVPNMD FT LAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSDPDGLVANLRRRGDRWYWH FT WDPQFIGGIAAFPPVEVTDVDRMNAAVATILRDEVPVLLVRGQVSDIVRQESADQFLSR FT FPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR" FT repeat_region 73603..73630 FT /note="28 bp inverted repeat at left end of IS6110 FT :TGAACCGCCCCGGCATGTCCGGAGACTC" FT repeat_region 73603..74957 FT /mobile_element="insertion sequence:IS6110-16" FT /note="IS6110-16, len: 1355 bp. Insertion sequence IS6110." FT CDS 73654..73980 FT /transl_table=11 FT /locus_tag="Rv3474" FT /product="POSSIBLE TRANSPOSASE FOR INSERTION ELEMENT IS6110 FT [FIRST PART]" FT /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION FT SEQUENCE IS6110." FT /note="Rv3474, (MTCY13E12.27), len: 108 aa. Possible FT transposase (first part), probably frameshifts (-1) with FT MTCY13E12.28|Rv3475 to make full length product. Identical FT to Q50686|YIA4_MYCTU INSERTION ELEMENT IS6110 HYPOTHETICAL FT 12.0 kDa PROTEIN (108 aa). BELONGS TO THE TRANSPOSASE FT FAMILY 8." FT /db_xref="GOA:P0C5G9" FT /db_xref="InterPro:IPR002514" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9" FT /protein_id="CAB08698.1" FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD FT RPAR" FT CDS <73875..74915 FT /transl_table=11 FT /locus_tag="Rv3475" FT /product="POSSIBLE TRANSPOSASE FOR INSERTION ELEMENT IS6110 FT [SECOND PART]" FT /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION FT SEQUENCE IS6110." FT /note="Rv3475, (MTCY13E12.28), len: 346 aa. Possible IS6110 FT transposase (second part), probably made by a frameshift FT (-1) with MTCY13E12.27|Rv3474. Identical to FT P19774|TRA9_MYCTU PUTATIVE TRANSPOSASE FOR INSERTION FT SEQUENCE ELEMENT IS986/IS6110 (278 aa)." FT /db_xref="GOA:P0C5G8" FT /db_xref="InterPro:IPR001584" FT /db_xref="InterPro:IPR012337" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8" FT /protein_id="CAB08699.1" FT /translation="AEALAAGQRRIAKGERDFKDRVGFLRGRARPASTLITRFIADHQG FT HREGPDGLRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAA FT NYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADL FT VQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAI FT EQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAE FT TINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQR FT QRPAAG" FT repeat_region complement(74930..74957) FT /note="28 bp inverted repeat at right end of IS6110 FT :TGAACCGCCCCGGTGAGTCCGGAGACTC" FT CDS complement(75195..76544) FT /transl_table=11 FT /gene="kgtP" FT /locus_tag="Rv3476c" FT /product="PROBABLE DICARBOXYLIC ACID TRANSPORT INTEGRAL FT MEMBRANE PROTEIN KGTP (DICARBOXYLATE TRANSPORTER)" FT /function="INVOLVED IN ACTIVE TRANSPORT OF DICARBOXYLIC FT ACID ACROSS THE MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION FT OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv3476c, (MTCY13E12.29c), len: 449 aa. Probable FT kgtP, dicarboxylate-transport integral membrane protein, FT possibly member of major facilitator superfamily (MFS), FT highly similar to others e.g. Q9HT43|PA5530 from FT Pseudomonas aeruginosa (435 aa), FASTA scores: opt: 1209, FT E(): 2.3e-68, (47.05% identity in 425 aa overlap); FT Q9I6Q9|PCAT|PA0229 from Pseudomonas aeruginosa (432 aa), FT FASTA scores: opt: 1131, E(): 1.8e-63, (40.4% identity in FT 438 aa overlap); Q9WWZ2 from Pseudomonas putida (429 aa), FT FASTA scores: opt: 1090, E(): 6.5e-61, (41.2% identity in FT 425 aa overlap); P17448|KGTP_ECOLI|WITA|B2587 from FT Escherichia coli strain K12 (432 aa), FASTA scores: opt: FT 1083, E(): 1.8e-60, (40.05% identity in 422 aa overlap); FT etc. Also similar to O05301|MTCI364.12|Rv1200 HYPOTHETICAL FT 44.6 KDA PROTEIN from Mycobacterium tuberculosis (425 aa), FT FASTA scores: E(): 5.2e-25, (28.5% identity in 382 aa FT overlap). Contains sugar transport protein signatures 1 and FT 2 (PS00216, PS00217). BELONG TO THE SUGAR TRANSPORTER FT FAMILY." FT /db_xref="GOA:O06339" FT /db_xref="InterPro:IPR005828" FT /db_xref="InterPro:IPR005829" FT /db_xref="InterPro:IPR016196" FT /db_xref="UniProtKB/TrEMBL:O06339" FT /protein_id="CAB08700.1" FT /translation="MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFAT FT YFEDQFFDRADRNSTVYVYAIFAVTFVTRPVGSWFLGRFADRRGRRAALTFSVSLMAAC FT SLIVALVPSRSSIGVAAPILLILCRLVQGFATGGEYGTSATYMSEAATRERRGYFSSFQ FT YVTLVGGHVLAQFTLLVILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQ FT ERLTAIKAGRDHDSGSLRELATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYGS FT QAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWFGVGGLIYTYVLVTYLPETRS FT PTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVGVGYALANSVFGGTAPLIYQ FT ALKERDQVPMFIAYVTACIAVSLIVYVFFIKNKADTYLDREQGFAFYGHA" FT misc_feature complement(75582..75635) FT /note="PS00216 Sugar transport proteins signature 1" FT misc_feature complement(76077..76154) FT /note="PS00217 Sugar transport proteins signature 2" FT CDS 76917..77213 FT /transl_table=11 FT /gene="PE31" FT /locus_tag="Rv3477" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3477, (MTCY13E12.30), len: 98 aa. Member of the FT Mycobacterium tuberculosis PE family (see Brennan & Delogu FT 2002), similar to O53941|Rv1791|MTV049.13 (99 aa), FASTA FT scores: opt: 373, E(): 4.3e-18, (64.65% identity in 99 aa FT overlap); MTCI364.07; MTCY21C12.10c; MTCY1A11.25c; FT MTC1A11.04; MTCY359.33; etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7D5G7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55600.1" FT /translation="MSFTAQPEMLAAAAGELRSLGATLKASNAAAAVPTTGVVPPAADE FT VSLLLATQFRTHAATYQTASAKAAVIHEQFVTTLATSASSYADTEAANAVVTG" FT CDS 77250..78431 FT /transl_table=11 FT /gene="PPE60" FT /locus_tag="Rv3478" FT /standard_name="mtb39c" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3478, (MTCY13E12.31), len: 393 aa. PPE60 FT (alternate gene name: mtb39c). Member of the M. FT tuberculosis PPE family, highly similar to others e.g. FT Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396 aa), FT FASTA scores: opt: 2165, E(): 1.1e-109, (85.35% identity in FT 396 aa overlap); MTCI364.08; MTCY10G2.10; MTCY03A2.22c; FT MTCY274.23c; MTCY164.34c; MTCY98.0029c; etc. Note that FT expression of Rv3478 was demonstrated in lysates by FT immunodetection (see Dillon et al., 1999)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q6MWX1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55601.1" FT /translation="MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAASA FT FQSVVWGLTVGSWIGSSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRL FT TVPPPVIAENRTELMTLTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATAT FT EALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSS FT KLGGLWTAVSPHLSPLSNVSSIANNHMSMMGTGVSMTNTLHSMLKGLAPAAAQAVETAA FT ENGVWAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARA FT LPLTSLTSAAQTAPGHMLGGLPLGHSVNAGSGINNALRVPARAYAIPRTPAAG" FT CDS 78644..81709 FT /transl_table=11 FT /locus_tag="Rv3479" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3479, (MTCY13E12.32), len: 1021 aa. Possible FT transmembrane protein, with hydrophobic stretches at FT C-terminus. Start changed since first submission (-54 aa)." FT /db_xref="GOA:O06342" FT /db_xref="InterPro:IPR002641" FT /db_xref="InterPro:IPR016035" FT /db_xref="InterPro:IPR019894" FT /db_xref="UniProtKB/TrEMBL:O06342" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08737.2" FT /translation="MAGVTREINLLAQASQWRRLGGTFPTNSQLTNESAASLRLYAQLI FT DLLDMVVDVDILSGTSAGGINAALLASSRVTGSDLGGIRDLWLDLGALTELLRDPRDKK FT TPSLLYGDERIFAALAKRLPKLATGPFPPTTFPEAARTPSTTLYITTTLLAGETSRFTD FT SFGTLVQDVDLRGLFTFTETDLARPDTAPALALAARSSASFPLAFEPSFLPFTKGTAKK FT GEVPARPAMAPFTSLTRPHWVSDGGLLDNRPIGVLFKRIFDRPARRPVRRVLLFVVPSS FT GPAPDPMHEPPPDNVDEPLGLIDGLLKGLAAVTTQSIAADLRAIRAHQDCMEARTDAKL FT RLAELAATLRNGTRLLTPSLLTDYRTREATKQAQTLTSALLRRLSTCPPESGPATESLP FT KSWSAELTVGGDADKVCRQQITATILLSWSQPTAQPLPQSPAELARFGQPAYDLAKGCA FT LTVIRAAFQLARSDADIAALAEVTEAIHRAWRPTASSDLSVLVRTMCSRPAIRQGSLEN FT AADQLAADYLQQSTVPGDAWERLGAALVNAYPTLTQLAASASADSGAPTDSLLARDHVA FT AGQLETYLSYLGTYPGRADDSRDAPTMAWKLFDLATTQRAMLPADAEIEQGLELVQVSA FT DTRSLLAPDWQTAQQKLTGMRLHHFGAFYKRSWRANDWMWGRLDGAGWLVHVLLDPRRV FT RWIVGERADTNGPQSGAQWFLGKLKELGAPDFPSPGYPLPAVGGGPAQHLTEDMLLDEL FT GFLDDPAKPLPASIPWTALWLSQAWQQRVLEEELDGLANTVLDPQPGKLPDWSPTSSRT FT WATKVLAAHPGDAKYALLNENPIAGETFASDKGSPLMAHTVAKAAATAAGAAGSVRQLP FT SVLKPPLITLRTLTLSGYRVVSLTKGIARSTIIAGALLLVLGVAAAIQSVTVFGVTGLI FT AAGTGGLLVVLGTWQVSGRLLFALLSFSVVGAVLALATPVVREWLFGTQQQPGWVGTHA FT YWLGAQWWHPLVVVGLIALVAIMIAAATPGRR" FT CDS complement(81733..83226) FT /transl_table=11 FT /locus_tag="Rv3480c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3480c, (MTCY13E12.33c), len: 497 aa. Conserved FT hypothetical protein, similar to many from Mycobacterium FT tuberculosis strains H37Rv and CDC1551 e.g. FT O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa), FT FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in 488 FT aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa), FT FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in FT 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA scores: FT opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); FT etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED FT MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA FT scores: opt: 272, E(): 1e-08, (28.85% identity in 485 aa FT overlap); and Q9RIU8|CM11.13c HYPOTHETICAL 47.1 KDA PROTEIN FT from Streptomyces coelicolor (446 aa), FASTA scores: opt: FT 254, E(): 1.1e-07, (30.4% identity in 497 aa overlap). FT SEEMS TO BELONG TO THE UPF0089 FAMILY. TBparse score is FT 0.917." FT /db_xref="InterPro:IPR004255" FT /db_xref="InterPro:IPR014292" FT /db_xref="UniProtKB/Swiss-Prot:O06343" FT /protein_id="CAB08703.1" FT /translation="MSQTARRLGPQDMFFLYSESSTTMMHVGALMPFTPPSGAPPDLLR FT QLVDESKASEVVEPWSLRLSHPELLYHPTQSWVVDDNFDLDYHVRRSALASPGDERELG FT IPVSRLHSHALDLRRPPWEVHFIEGLEGGRFAIYIKMHHSLIDGYTGQKMLARSLSTDP FT HDTTHPLFFNIPTPGRSPADTQDSVGGGLIAGAGNVLDGLGDVVRGLGGLVSGVGSVLG FT SVAGAGRSTFELTKALVNAQLRSDHEYRNLVGSVQAPHCILNTRISRNRRFATQQYPLD FT RLKAIGAQYDATINDVALAIIGGGLRRFLDELGELPNKSLIVVLPVNVRPKDDEGGGNA FT VATILATLGTDVADPVQRLAAVTASTRAAKAQLRSMDKDAILAYSAALMAPYGVQLAST FT LSGVKPPWPYTFNLCVSNVPGPEDVLYLRGSRMEASYPVSLVAHSQALNVTLQSYAGTL FT NFGFIGCRDTLPHLQRLAVYTGEALDQLAAADGAAGLGS" FT CDS complement(83317..84006) FT /transl_table=11 FT /locus_tag="Rv3481c" FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3481c, (MTCY13E12.34c), len: 229 aa. Probable FT integral membrane protein. No real similarity with others." FT /db_xref="UniProtKB/TrEMBL:O06344" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08704.1" FT /translation="MRGLLPVAGHWVSVLTGLVPLALVIALSPLSVIPAVLVVHSPQPR FT PSSLAFLGGWLLGLAVVTAVFVAASGALGGLSTTSPAWASWLRVVLGSALIVFGVLRWL FT TRHRHTEMPGWMRAFASFTPARAGLVGAVLVVVRPEVLIICAAAGLAIGSGGHGAAGSW FT IYTAFFAMLAASTVAIPILAYVAAGDRLDDSLERLKDWMEKNHAGMVAAILVVIGLLLL FT YNGVHAM" FT CDS complement(84148..84930) FT /transl_table=11 FT /locus_tag="Rv3482c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3482c, (MTCY13E12.35c), len: 260 aa. Probable FT conserved membrane protein. N-terminal region shares some FT similarity with N-terminus of O88067|SCI35.32c PUTATIVE FT MEMBRANE PROTEIN from Streptomyces coelicolor (319 aa), FT FASTA scores: opt: 155, E(): 0.023, (54.55% identity in 33 FT aa overlap); and with C-terminus of O06254|Rv3437|MTCY77.09 FT HYPOTHETICAL 17.9 KDA PROTEIN from Mycobacterium FT tuberculosis strain H37Rv (alias AAK47883|MT3542.1 from FT strain CDC1551) (158 aa), FASTA scores: opt: 140, E(): FT 0.11, (58.8% identity in 34 aa overlap). Some similarity to FT others e.g. Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN from FT Streptomyces coelicolor (347 aa), FASTA scores: opt: 131, FT E(): 0.75, (29.4% identity in 221 aa overlap). First start FT taken." FT /db_xref="InterPro:IPR018929" FT /db_xref="UniProtKB/TrEMBL:O06345" FT /protein_id="CAB08705.1" FT /translation="MEHDVATSPPAGWYTDPDGSAGQRYWDGDRWTRHRRPNPSAPRSP FT LALRVDGLRSRWLGMPAGLRLTVPVAAVLTMVGVAVYAWIRPLPDDWSQLPKRLSCQLR FT PGPTPPATITVASVDVSHPRGAVLRLVVRFAEPLPPSPSGSFASGFAGYLLTYTIANNG FT KEFAELGPQQDTDELAIRKPGESRGTEPNMRPDRNTNARRTAPDTVEINLETKRLGLDQ FT APVDPQLTFAAQFRTPSTVTVDFGSQFCQGERLAGQRR" FT CDS complement(84974..85636) FT /transl_table=11 FT /locus_tag="Rv3483c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3483c, (MTCY13E12.36c), len: 220 aa. Conserved FT hypothetical protein (see citation below), similar to FT Q9CC94|ML1099 PUTATIVE LIPOPROTEIN from Mycobacterium FT leprae (202 aa), FASTA scores: opt: 276, E(): 1.4e-08, FT (33.1% identity in 148 aa overlap). Also showing similarity FT with Mycobacterium tuberculosis proteins FT Q11065|LPRE_MYCTU|LPRE|Rv1252c|MT1291|MTCY50.30. PUTATIVE FT LIPOPROTEIN PRECURSOR (202 aa), FASTA scores: opt: 276, FT E(): 1.4e-08, (29.5% identity in 200 aa overlap); FT O53445|Rv1097c|MTV017.50c HYPOTHETICAL 29.9 KDA PROTEIN FT (293 aa), FASTA scores: opt: 161, E(): 0.047, (25.4% FT identity in 118 aa overlap); FT P71882|LPPP_MYCTU|Rv2330c|MT2392|MTCY3G12.04 PUTATIVE FT LIPOPROTEIN PRECURSOR (175 aa), FASTA scores: opt: 146, FT E(): 0.21, (28.25% identity in 184 aa overlap); and FT O06170|Rv2507|MTCY07A7.13 HYPOTHETICAL 28.5 KDA PROTEIN FT (273 aa), FASTA scores: opt: 148, E(): 0.23, (25.15% FT identity in 191 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06346" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08706.1" FT /translation="MSDEIDPDWPAPAYQPSDDVDTTPPAPGGSWPTAWLVALVVLACV FT AAAVVAYAGMHRVRPGANQAAPATTSAPARPTSPASQVGPCGPDEATAVRAALAQLAPD FT SKTGRPWNSTPEDSNYDPCADLSAVLVTVQDATNSSPDQALMFHRGTFVGTATPRAYPF FT TNLIGPASTNDIVVLSYRTRQSCDGCQDGILTIVGFAWRGDHVQILDSLPELFDAPP" FT CDS 85902..87440 FT /transl_table=11 FT /gene="cpsA" FT /locus_tag="Rv3484" FT /product="POSSIBLE CONSERVED PROTEIN CPSA" FT /function="NOT KNOW." FT /note="Rv3484, (MTCY13E12.37), len: 512 aa. Possible cpsA, FT hypothetical protein, equivalent to Q50160|CPSA|ML2247 FT HYPOTHETICAL PROTEIN CPSA from Mycobacterium leprae (516 FT aa), FASTA scores: opt: 2557, E(): 1.6e-143, (74.9% FT identity in 518 aa overlap); and with good similarity to FT Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium FT leprae (489 aa), FASTA scores: opt: 855, E(): 4.6e-43, FT (34.45% identity in 502 aa overlap). Also similar (or with FT similarity) to hypothetical proteins from Mycobacterium FT tuberculosis: P96872|Rv3267|MTCY71.07 (498 aa), FASTA FT scores: opt: 928, E(): 2.3e-47, (37.35% identity in 498 aa FT overlap); and O53834|Rv0822c|MTV043.14c (684 aa), FASTA FT scores: opt: 425, E(): 1.5e-17, (26.15% identity in 524 aa FT overlap). Shows also similarity with various bacterial FT proteins e.g. Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL FT PROTEIN from Streptomyces coelicolor (507 aa), FASTA FT scores: opt: 329, E(): 5.3e-12, (28.85% identity in 478 aa FT overlap); Q9K4E6|2SC6G5.02 CONSERVED HYPOTHETICAL PROTEIN, FT POSSIBLE MEMBRANE PROTEIN, from Streptomyces coelicolor FT (382 aa), FASTA scores: opt: 305, E(): 1.1e-10, (29.8% FT identity in 386 aa overlap); O69850|SC1C3.08c PUTATIVE FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (366 FT aa), FASTA scores: opt: 304, E(): 1.2e-10, (29.6% identity FT in 395 aa overlap); Q9KZK3|SCE34.23 PUTATIVE FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (396 FT aa), FASTA scores: opt: 296, E(): 3.8e-10, (31.25% identity FT in 349 aa overlap); AAK43602|CPSA CPSA PROTEIN from FT Streptococcus agalactiae (485 aa), FASTA scores: opt: 250, FT E(): 2.4e-07, (30.25% identity in 162 aa overlap); etc." FT /db_xref="InterPro:IPR004474" FT /db_xref="UniProtKB/TrEMBL:O06347" FT /protein_id="CAB08707.1" FT /translation="MARSEGNRPRHRAVPQPSRIRKRLSRGVMTLVSVVALLMTGAGYW FT VAHGALGGITISQALTPEDPRSSGNNMNILLIGLDSRKDQEGNDLPWSVLKQLHAGDSD FT DGGYNTNTLILVHVGADGKVVAFSIPRDDWVPFTGVPGYNHIKIKEAYGLTKQYVAEQL FT ANQGVSDRKELETRGREAARAATLRAVRSLTGVPIDYFAEINLAGFYDLAQTLGGVDVC FT LNHAVYDSYSGADFPAGRQRLNAAQALAFVRQRHGLDNGDLDRTHRQQAFLSSVMRELQ FT DSGTFTNLDRLDNLMAVARKDVVLSAGWDEDLFRRMGDLAGGNVEFRTLPVVRYDNIDG FT QDVNIIDPTAIRAEVAAAFGSAPPTSQTAAAAKPNPSTVVDVVNAGSISGLASQVSGAL FT LKRGYTAGQVRDRESGDPFTTAIEYGAGAETDAQNVADLLGIDAPNHPDPAVAPGHIRV FT TVDTNFSLPAPDEATAAATSTETSTYPLYGGGTTTDPTPDQGAPIDGGGVPCVN" FT CDS complement(87446..88390) FT /transl_table=11 FT /locus_tag="Rv3485c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; SUPPOSED TO BE INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3485c, (MTCY13E12.38c), len: 314 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), similar, FT but longer 41 aa, to P71824|Rv0769|MTCY369.14 PUTATIVE FT SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE CY369.14 from FT Mycobacterium tuberculosis (248 aa), FASTA scores: opt: FT 462, E(): 1.8e-19, (34.0% identity in 253 aa overlap). Also FT similar to various dehydrogenases e.g. FT P25529|HDHA_ECOLI|HSDH|B1619 NAD-DEPENDENT 7 FT ALPHA-HYDROXYSTEROID DEHYDROGENASE (SDR FAMILY) (EC FT 1.1.1.159) from Escherichia coli strain K12 (alias FT BAB35750|ECS2327 or AAG56608|HDHA for strain O157:H7) (255 FT aa), FASTA scores: opt: 462, E(): 1.8e-19, (34.7% identity FT in 248 aa overlap); Q9FD15|RUBG PUTATIVE REDUCTASE (SDR FT FAMILY) from Streptomyces collinus (249 aa), FASTA scores: FT opt: 446, E(): 1.5e-18, (36.1% identity in 255 aa overlap); FT BAB51974|MLL5540 PUTATIVE DEHYDROGENASE from Rhizobium loti FT (Mesorhizobium loti) (253 aa), FASTA scores: opt: 442, E(): FT 2.5e-18, (36.25% identity in 251 aa overlap); FT Q08632|SDR1_PICAB SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE FT (SDR FAMILY) from Picea abies (Norway spruce) (Picea FT excelsa) (271 aa), FASTA scores: opt: 441, E(): 3.1e-18, FT (32.3% identity in 260 aa overlap); Q9A326|CC3380 FT 2-DEOXY-D-GLUCONATE 3-DEHYDROGENASE from Caulobacter FT crescentus (260 aa), FASTA scores: opt: 436, E(): 5.7e-18, FT (32.8% identity in 253 aa overlap); Q16698|DECR_HUMAN FT 2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR (EC FT 1.3.1.34) from Homo sapiens (Human) (335 aa), FASTA scores: FT opt: 430, E(): 1.5e-17, (30.4% identity in 306 aa overlap); FT etc. Contains short-chain alcohol dehydrogenase family FT signature (PS00061). BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES FAMILY (SDR)." FT /db_xref="GOA:O06348" FT /db_xref="HSSP:1DFI" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O06348" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08708.1" FT /translation="MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQD FT RTYLVTGGGSGIGKGVAAGLVAAGAAVMIVGRNPDKLAAAVKDIEALKTGAIGYEPADI FT TDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTMYVL FT KHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSWVRVN FT SIRPGLIRTDLVVPVTESPELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASWITGQV FT INVDGGHMLRRGPDFSPMLEPVFGADGLRGVVG" FT misc_feature complement(87758..87844) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 88596..89045 FT /transl_table=11 FT /locus_tag="Rv3486" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3486, (MTCY13E12.39), len: 149 aa. Conserved FT hypothetical protein, similar to Q9RC47|YFID|BH3304 FT HYPOTHETICAL PROTEIN from Bacillus halodurans (129 aa), FT FASTA scores: opt: 186, E(): 2.1e-05, (40.0% identity in 95 FT aa overlap); and Q9KKT1|VCA1019 HYPOTHETICAL PROTEIN from FT Vibrio cholerae (148 aa), FASTA scores: opt: 128, E(): FT 0.15, (35.25% identity in 139 aa overlap). Some similarity FT to other proteins e.g. P54720|YFID_BACSU HYPOTHETICAL FT PROTEIN from Bacillus subtilis (134 aa), FASTA scores: opt: FT 165, E(): 0.00052, (31.75% identity in 126 aa overlap). FT Equivalent to AAK47949 from Mycobacterium tuberculosis FT strain CDC1551 (163 aa) but shorter 14 aa." FT /db_xref="InterPro:IPR011637" FT /db_xref="UniProtKB/TrEMBL:O06349" FT /protein_id="CAB08709.1" FT /translation="MHAEGPPSVICIRLLVGLVFLSEGIQKFMYPDQLGPGRFERIGIP FT AATFFADLDGVVEIVCGTLVLLGLLTRVAAVPLLIDMVGAIVLTKLRALQPGGFLGVEG FT FWGMAHAARTDLSMLLGLIFLLWSGPGRWSLDRRLSKRATACGAR" FT CDS complement(88998..89831) FT /transl_table=11 FT /gene="lipF" FT /locus_tag="Rv3487c" FT /product="PROBABLE ESTERASE/LIPASE LIPF" FT /function="UNKNOWN; LIPOLYTIC ENZYME INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="3.-.-.-" FT /note="Rv3487c, (MTCY13E12.41c), len: 277 aa. Probable FT lipF, esterase/lipase (EC 3.-.-.-) (see citation below), FT highly similar, but shorter 50 aa, to FT O53424|LIPU|Rv1076|MTV017.29 PUTATIVE ESTERASE/LIPASE from FT Mycobacterium tuberculosis (297 aa), FASTA scores: opt: FT 1229, E(): 3.3e-71, (76.4% identity in 246 aa overlap); and FT similar to other putative lipases from Mycobacterium FT tuberculosis e.g. P71759|LIPK|RV2385|MTCY253.36c (306 aa), FT FASTA scores: opt: 468, E(): 1.2e-22, (36.2% identity in FT 254 aa overlap). Equivalent, but shorter 79 aa, to FT Q9ZBM4|MLCB1450.08|ML0314 PUTATIVE HYDROLASE (PUTATIVE FT ESTERASE) from Mycobacterium leprae (335 aa), FASTA scores: FT opt: 1225, E(): 6.6e-71, (73.6% identity in 250 aa FT overlap). Also similar to esterases and lipases of around FT 300 aa e.g. Q44087|EST ESTERASE PRECURSOR from FT Acinetobacter lwoffii (303 aa), FASTA scores: opt: 428, FT E(): 4.3e-20, (31.85% identity in 251 aa overlap); FT P18773|EST_ACICA ESTERASE (EC 3.1.1.-) from Acinetobacter FT calcoaceticus (303 aa), FASTA scores: opt: 420, E(): FT 1.4e-19, (31.5% identity in 251 aa overlap); Q9KIU1 FT ESTERASE from uncultured bacterium Plasmid pAH116 (308 aa), FT FASTA scores: opt: 405, E(): 1.3e-18, (35.1% identity in FT 242 aa overlap); Q9X8J4|SCE9.22 PUTATIVE ESTERASE from FT Streptomyces coelicolor (266 aa), FASTA scores: opt: 390, FT E(): 1e-17, (35.85% identity in 237 aa overlap); etc. FT Equivalent to AAK47950 from Mycobacterium tuberculosis FT strain CDC1551 (327 aa) but shorter 50 aa. TBparse score is FT 0.940." FT /db_xref="GOA:O06350" FT /db_xref="InterPro:IPR002168" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:O06350" FT /protein_id="CAB08710.1" FT /translation="MRAPGVRAADGAGRVVLYLHGGAFVMCGPNSHSRIVNALSGFAES FT PVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQIVLAGDSAGGYLALALAQRLQ FT CDDEKPAAIVAISPLLQLAKGPKQDHPNIGTDAMFPARAFDALAAWVRAAAAKNMVDGR FT PEDLYEPLDHIESSLPPTLIHVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQ FT LATPLVPEATRSLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI" FT CDS 90491..90814 FT /transl_table=11 FT /locus_tag="Rv3488" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3488, (MTCY13E12.41), len: 107 aa. Hypothetical FT protein, similar to various bacterial proteins e.g. FT O28730|AF1542 CONSERVED HYPOTHETICAL PROTEIN from FT Archaeoglobus fulgidus (101 aa), FASTA scores: opt: 321, FT E(): 6.4e-15, (50.55% identity in 87 aa overlap); O50207 FT SQ1_IV (FRAGMENT) from Rhodococcus erythropolis (59 aa), FT FASTA scores: opt: 298, E(): 1.4e-13, (71.2% identity in 59 FT aa overlap); Q9KFB0|BH0575 BH0575 PROTEIN from Bacillus FT halodurans (102 aa), FASTA scores: opt: 294, E(): 4.1e-13, FT (43.15% identity in 95 aa overlap); etc. Also similar to FT Mycobacterium tuberculosis P71704|Rv0047c|MTCY21D4.10c (180 FT aa) (37.8% identity in 82 aa overlap)." FT /db_xref="InterPro:IPR005149" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:O06351" FT /protein_id="CAB08711.1" FT /translation="MREFQRAAVRLHILHHAADNEVHGAWLTQELSRHGYRVSPGTLYP FT TLHRLEADGLLVSEQRVVDGRARRVYRATPAGRAALTEDRRALEELAREVLGGQSHTAG FT NGT" FT CDS 90896..91060 FT /transl_table=11 FT /locus_tag="Rv3489" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3489, (MTCY13E12.42), len: 54 aa. Hypothetical FT unknown protein. No similarity with other proteins." FT /db_xref="UniProtKB/TrEMBL:O06352" FT /protein_id="CAB08712.1" FT /translation="MSTKSDHGEIGDVEPLADSTASQARRVVAAYANDADECRIFLSML FT GIGPAKLES" FT CDS 91060..92562 FT /transl_table=11 FT /gene="otsA" FT /locus_tag="Rv3490" FT /product="PROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE FT SYNTHASE [UDP-FORMING] OTSA (TREHALOSE-6-PHOSPHATE FT SYNTHASE) (UDP-GLUCOSE-GLUCOSEPHOSPHATE FT GLUCOSYLTRANSFERASE) (TREHALOSEPHOSPHATE-UDP FT GLUCOSYLTRANSFERASE) (TREHALOSE-6-PHOSPHATE SYNTHETASE) FT (TREHALOSE-PHOSPHATE SYNTHASE) (TREHALOSE-PHOSPHATE FT SYNTHETASE) (TRANSGLUCOSYLASE) (TREHALOSEPHOSPHATE-UDP FT GLUCOSYL TRANSFERASE)" FT /function="INVOLVED IN OSMOREGULATORY TREHALOSE FT BIOSYNTHESIS. Mycobacteria can produce trehalose from FT glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) FT from glycogen-like alpha(1-->4)-linked glucose polymers FT (the TreY-TreZ pathway) and from maltose (the TreS pathway) FT [CATALYTIC ACTIVITY: UDP-GLUCOSE + D-GLUCOSE 6-PHOSPHATE = FT UDP + ALPHA,ALPHA-TREHALOSE 6-PHOSPHATE]." FT /EC_number="2.4.1.15" FT /note="Rv3490, (MTCY13E12.43), len: 500 aa. Probable otsA, FT alpha, alpha-trehalose-phosphate synthase (EC 2.4.1.15) FT (see citations below), equivalent to Q50167|OTSA|ML2254 FT PROBABLE TREHALOSE-PHOSPHATE SYNTHASE from Mycobacterium FT leprae (498 aa), FASTA scores: opt: 2706, E(): 1.6e-166, FT (80.3% identity in 497 aa overlap). Also similar to others FT e.g. Q92410|TPS1_CANAL from Candida albicans (Yeast) (478 FT aa), FASTA scores: opt: 895, E(): 4.9e-50, (37.15% identity FT in 479 aa overlap); FT Q00764|TPS1_YEASTTPS1|CIF1|BYP1|FDP1|GGS1|GLC6|YBR126c|YB FT R0 922 from Saccharomyces cerevisiae (Baker's yeast) (495 FT aa), FASTA scores: opt: 847, E(): 6.2e-47, (36.1% identity FT in 490 aa overlap); BAB48232|MLL0691 from Rhizobium loti FT (Mesorhizobium loti) (520 aa), FASTA scores: opt: 884, E(): FT 2.7e-49, (36.2% identity in 478 aa overlap); etc. FT Equivalent to AAK47953 from Mycobacterium tuberculosis FT strain CDC1551 (478 aa) but longer 22 aa." FT /db_xref="GOA:O06353" FT /db_xref="HSSP:1GZ5" FT /db_xref="InterPro:IPR001830" FT /db_xref="UniProtKB/Swiss-Prot:O06353" FT /protein_id="CAB08713.1" FT /translation="MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWKR FT SPGGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPVRLSTTDI FT AQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEAASRAAAHGATVWVQDY FT QLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIQGLLGADLVGFHLPGGA FT QNFLILSRRLVGTDTSRGTVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAARDRNI FT RRRAREIRTELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVVVQLATP FT SRERVESYQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVMLVT FT PLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALN FT QTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGAHPRGQG" FT CDS 92714..93292 FT /transl_table=11 FT /locus_tag="Rv3491" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3491, (MTCY13E12.44), len: 192 aa. Hypothetical FT unknown protein. No significant homology with other FT proteins." FT /db_xref="UniProtKB/TrEMBL:O06354" FT /protein_id="CAB08714.1" FT /translation="MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQA FT GVSGVTWTITALCDQPSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFSGR FT ARMSSMLWTFQVNQADGVACPDGSTAPSSETYAFSDETLTGTHTTVHGAVCGLQPKLSK FT QPFSLQLIGPPPSPVQRYPLYCNNIAMCY" FT CDS complement(93289..93771) FT /transl_table=11 FT /locus_tag="Rv3492c" FT /product="CONSERVED HYPOTHETICAL MCE ASSOCIATED PROTEIN" FT /function="UNKNOWN" FT /note="Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved FT hypothetical Mce-associated protein, showing some FT similarity to hypothetical Mycobacterium tuberculosis FT proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) FT (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% FT identity in 154 aa overlap); and FT Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa), FT FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 FT aa overlap). Contains lipocalin signature at C-terminus FT (PS00213)." FT /db_xref="UniProtKB/TrEMBL:O06355" FT /protein_id="CAB08715.1" FT /translation="MRRLISVAYALMVATIVGLSAAGGWFYWDRVQTGGEASARALLPK FT LAMQEIPQVFGYDYQTVERSLTAVYPLLTPDYRQEFQKSANAQIIPEAKKREVVVQANV FT VGVGVMDAKRDCASVMVYLNRTVTDKTRQPLYDGSRLRVDFQRIDGKWLIAYITPI" FT misc_feature complement(93307..93342) FT /note="PS00213 Lipocalin signature" FT CDS complement(93771..94499) FT /transl_table=11 FT /locus_tag="Rv3493c" FT /product="CONSERVED HYPOTHETICAL MCE ASSOCIATED ALANINE AND FT VALINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved FT hypothetical Mce-associated ala-, val-rich protein, showing FT weak similarity to O07422|Z97050|Rv0178|MTCI28.18 FT HYPOTHETICAL 25.9 KDA PROTEIN (near Mce operon1) from FT Mycobacterium tuberculosis (244 aa), FASTA scores: opt: FT 163, E(): 0.046, (24.65% identity in 211 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06356" FT /protein_id="CAB08738.1" FT /translation="MAADTGVAGGQQSTTRRARRKASRPAGPAEGESSRPAQGAATVRA FT AARTESKPAKAAKPALRPVKPPPRRPAHRVLVGWLSLAAGLLAIAALAWGVTALVMQNR FT DADARQARNQRFVDAATQTVVNMFSYTPDTIDESVNRFVNGTSGPLRGMLNANNNVDNL FT KGLFRATNATSEAVVNGAALEGIDEISDNASVLVSVRVTVADIDGVNKPSMPYRLRVIV FT HEDENGRMTGYDLKYPDGGN" FT CDS complement(94499..96193) FT /transl_table=11 FT /gene="mce4F" FT /locus_tag="Rv3494c" FT /product="MCE-FAMILY PROTEIN MCE4F" FT /function="UNKNOWN, BUT THOUGHT INVOLVED IN HOST CELL FT INVASION." FT /note="Rv3494c, (MTV023.01c), len: 564 aa. mce4F; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), similar to Mycobacterium FT tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 FT aa); O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); and FT O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to FT others e.g. Q9CD09|MCE1F|ML2594 PUTATIVE SECRETED PROTEIN FT from Mycobacterium leprae (516 aa), FASTA scores: opt: FT 1040, E(): 3.6e-31, (35.9% identity in 529 aa overlap); FT Q9F361|SC8A2.02c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (433 aa), FASTA scores: opt: 570, FT E(): 3.7e-14, (30.8% identity in 458 aa overlap); etc. Has FT hydrophobic stretch, possibly a signal peptide at the FT N-terminus. TBparse score is 0.897." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O53539" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17731.1" FT /translation="MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSAD FT FVAGGGLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRSVSAI FT GEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETLLGSLGDTRLRELLH FT EAFIATNGAGPELARLIESARLLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLA FT DGLARFTWQLRAADPRLRDTLADAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIY FT HKSIEQLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLVRSPA FT DESVREIPRDMYCKTAQNDPSTVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTNPW FT RGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDPGVPIVGPPPPGQVAGPGPAPHQPAQ FT PAPPPNDNGPPPPFTSWMPPGYPPEPPQVPYPATIPPPPPPEGTGPPPGPAPGPQPQAS FT GPAYTIYDQLSGAFADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL" FT CDS complement(96204..97358) FT /transl_table=11 FT /gene="lprN" FT /locus_tag="Rv3495c" FT /standard_name="mce4E" FT /product="POSSIBLE MCE-FAMILY LIPOPROTEIN LPRN (MCE-FAMILY FT LIPOPROTEIN MCE4E)" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv3495c, (MTV023.02c), len: 384 aa. Possible lprN FT (alternate gene name: mce4E), lipoprotein which belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E FT (390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); FT and O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa). Also FT similar to others e.g. Q9F360|SC8A2.03c PUTATIVE SECRETED FT PROTEIN from Streptomyces coelicolor (413 aa), FASTA FT scores: opt: 656, E(): 2.2e-32, (37.55% identity in 317 aa FT overlap); Q9CD10|LPRK|ML2593 PUTATIVE LIPOPROTEIN from FT Mycobacterium leprae (392 aa), FASTA scores: opt: 616, E(): FT 5.5e-30, (28.95% identity in 373 aa overlap); etc. Contains FT possible signal sequence and appropriately positioned FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site. TBparse score is 0.897." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O53540" FT /protein_id="CAA17732.1" FT /translation="MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHGEGAYSVT FT VEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVKLDLDKNVLLPANAVAK FT VSQTSLLGSLHVELAPPTDRPPTGRLVDGSRITEANTDRFPTTEEVFSALGVVVNKGNV FT GALEEIIDETHQAVAGRQAQFVNLVPRLAELTAGLNRQVHDIIDALDGLNRVSAILARD FT KDNLGRALDTLPDAVRVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYS FT IVKALNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFFTTA FT YFDPNMAHMDEILNPPDFLIGELANLSGQAADPFKIPPGTASGQ" FT misc_feature complement(97296..97328) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(97355..98710) FT /transl_table=11 FT /gene="mce4D" FT /locus_tag="Rv3496c" FT /product="MCE-FAMILY PROTEIN MCE4D" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv3496c, (MTV023.03c), len: 451 aa. mce4D; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07416|Rv0172|MTCI28.12|mce1D (530 aa); FT O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and FT O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to FT others e.g. Q9CD11|MCE1D|ML2592 PUTATIVE SECRETED PROTEIN FT from Mycobacterium leprae (531 aa), FASTA scores: opt: 837, FT E(): 2.6e-34, (34.55% identity in 446 aa overlap); FT Q9F359|SC8A2.04c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (337 aa), FASTA scores: opt: 606, FT E(): 4.9e-23, (32.35% identity in 300 aa overlap); etc. FT Hydrophobic region at N-terminus. TBparse score is 0.891." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O53541" FT /protein_id="CAA17733.1" FT /translation="MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNKRTIVGY FT FTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVDVQAVIMSPNLV FT AARFIQLTPVYTGGAVLPDNGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQGPL FT GAAINQAADTLDGNGDSLHNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQ FT IVQFAGHVASVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ FT TLSDQSENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGSFDTAA FT GPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKGQIIYDTPATEAKSE FT TPVPELTWVPAGGGAPVGNPADLQSLLVPPAPGPAPAPPAPGAGPGEHGGGG" FT CDS complement(98707..99780) FT /transl_table=11 FT /gene="mce4C" FT /locus_tag="Rv3497c" FT /product="MCE-FAMILY PROTEIN MCE4C" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv3497c, (MTV023.04c), len: 357 aa. mce4C; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07415|R0171|MTCI28.11|mce1C (515 aa); FT O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); and FT O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to FT others e.g. Q9F358|SC8A2.05c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (351 aa), FASTA scores: opt: 658, FT E(): 1.1e-30, (33.95% identity in 318 aa overlap); FT Q9CD12|MCE1C|ML2591 PUTATIVE SECRETED PROTEIN from FT Mycobacterium leprae (519 aa), FASTA scores: opt: 555, E(): FT 1.2e-24, (28.35% identity in 328 aa overlap); etc. FT Hydrophobic region at N-terminus. TBparse score is 0.889." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="InterPro:IPR008360" FT /db_xref="UniProtKB/TrEMBL:O53542" FT /protein_id="CAA17734.1" FT /translation="MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGK FT TYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSLAAIR FT TDTILGERSIAVSPAGSGKSTTIPLSRTTTPYTLNGVLQDLGRNANDLNRPQFEQALNV FT FTQALHDATPQVRGAVDGLTSLSRALNRRDEALQGLLAHAKSVTSVLSERAEQVNKLVE FT DGNQLFAALDARRAALSALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERR FT DYITEALKRLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPGKLPDSLAD FT YLRGFIQERWIIRPKSP" FT CDS complement(99770..100822) FT /transl_table=11 FT /gene="mce4B" FT /locus_tag="Rv3498c" FT /product="MCE-FAMILY PROTEIN MCE4B" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv3498c, (MTV023.05c), len: 350 aa. mce4B; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07414|Rv0170|MTCI28.10|mce1B (346 aa); FT O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); and FT O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to FT others e.g. Q9CD13|MCE1B|ML2590 PUTATIVE SECRETED PROTEIN FT from Mycobacterium leprae (346 aa), FASTA scores: opt: 803, FT E(): 6.1e-41, (41.05% identity in 346 aa overlap); FT Q9F357|SC8A2.06c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (354 aa), FASTA scores: opt: 624, FT E(): 3.4e-30, (32.55% identity in 338 aa overlap); etc. FT Hydrophobic region at N-terminus. TBparse score is 0.878." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O53543" FT /protein_id="CAA17735.1" FT /translation="MAGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTVY FT HATFTDASRLKAGQKVRIAGVPVGSVKAVKLNPDHSIDVAFAIDRSYTLYSSTRAVIRY FT ENLVGDRFLEITSGPGELRKLPPGGTINVAHTQPALDLDALLGGLRPVLKGFDADKINT FT ITSAVIELLQGQGGPLANVLADTGAFSAALGARDQLIGEVITNLNAVLATVDAKSAQFS FT ASVDQLQQLVSGLAKNRDPIAGAISPLASTTTDLTELLRNSRRPLQGILENARPLATEL FT DNRKAEVNNDIEQLGEDYLRLSALGSYGAFFNIYFCSVTIKINGPAGSDILLPIGGQPD FT PSKGRCAFAK" FT CDS complement(100822..102024) FT /transl_table=11 FT /gene="mce4A" FT /locus_tag="Rv3499c" FT /standard_name="mce4" FT /product="MCE-FAMILY PROTEIN MCE4A" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv3499c, (MTV023.06c), len: 400 aa. mce4A; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); FT O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and FT O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar FT to others e.g. Q9F356|SC8A2.07c PUTATIVE SECRETED PROTEIN FT from Streptomyces coelicolor (418 aa), FASTA scores: opt: FT 619, E(): 7.8e-30, (32.4% identity in 352 aa overlap); FT Q9S4U5|MCE1 MYCOBACTERIAL CELL ENTRY PROTEIN from FT Mycobacterium bovis BCG (454 aa), FASTA scores: opt: 529, FT E(): 2.1e-24, (30.35% identity in 448 aa overlap); FT Q9CD14|MCE1A|ML2589 from Mycobacterium leprae (441 aa), FT FASTA scores: opt: 515, E(): 1.4e-23, (28.35% identity in FT 430 aa overlap); etc. Contains a possible N-terminal signal FT sequence. TBparse score is 0.914. Note that previously FT known as mce4." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:Q7D5E7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55602.1" FT /translation="MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTV FT SSPRAGLVMEKGAKVKYRGIQVGKVTDISYSGNQARLKLAIDSGEMGFIPSNATVRIAG FT NTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNAT FT LSALSEGLRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDLNT FT VFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTS FT DYSPVFGCLFKGIARGVKEFAPLIGVRKAGLFTSSSFVLGAPSYTYPESLPIVNASGGP FT NCRGLPDIPTKQTGGSFYRAPFLVTDNALIPYQPFTELQVDAPSTLQFLFNGAFAERDD FT F" FT CDS complement(102044..102886) FT /transl_table=11 FT /gene="yrbE4B" FT /locus_tag="Rv3500c" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE4B" FT /function="UNKNOWN" FT /note="Rv3500c, (MTV023.07c), len: 280 aa. yrbE4B, FT hypothetical unknown integral membrane protein, part of FT mce4 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); FT O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and FT O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly FT similar to conserved hypothetical integral membrane FT proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. FT Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa), FT FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity in FT 269 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus FT influenzae (261 aa), FASTA scores: opt: 270, E(): 6e-11, FT (25.4% identity in 264 aa overlap); etc. TBparse score is FT 0.887." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:O53545" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17737.1" FT /translation="MSYDVTIRFRRFFSRLQRPVDNFGEQALFYGETMRYVPNAITRYR FT KETVRLVAEMTLGAGALVMIGGTVGVAAFLTLASGGVIAVQGYSSLGDIGIEALTGFLS FT AFLNVRVVAPVIAGIALAATIGAGATAQLGAMRVSEEIDAVECMAVHSVSYLVSTRLIA FT GLVAIIPLYSLSVLAAFFAARFTTVFVNGQSAGLYDHYFNTFLIPSDLLWSFMQAIAMS FT IAVMLVHTYYGYNASGGSVGVGVAVGQAVRTSLIVVVVITLFISLAVYGASGNFNLSG" FT CDS complement(102921..103685) FT /transl_table=11 FT /gene="yrbE4A" FT /locus_tag="Rv3501c" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE4A" FT /function="UNKNOWN" FT /note="Rv3501c, (MTV023.08c), len: 254 aa. yrbE4A, FT hypothetical unknown integral membrane protein, part of FT mce4 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); FT O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and FT O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly FT similar to conserved hypothetical integral membrane FT proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. FT Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa), FT FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity in FT 247 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus FT influenzae (261 aa), FASTA scores: opt: 313, E(): 3e-14, FT (25.7% identity in 241 aa overlap); etc. TBparse score is FT 0.900." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:O53546" FT /protein_id="CAA17738.1" FT /translation="MIQQLAVPARAVGGFFEMSMDTARAAFRRPFQFREFLDQTWMVAR FT VSLVPTLLVSIPFTVLVAFTLNILLREIGAADLSGAGTAFGTITQLGPVVTVLVVAGAG FT ATAICADLGARTIREEIDAMRVLGIDPIQRLVVPRVLASTLVALLLNGLVCAIGLSGGY FT AFSVFLQGVNPGAFINGLTVLTGLRELILAEIKALLFGVMAGLVGCYRGLTVKGGPKGV FT GNAVNETVVYAFICLFVINVVMTAIGVRISAQ" FT CDS complement(103911..104864) FT /transl_table=11 FT /locus_tag="Rv3502c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; SUPPOSED INVOLVEMENT IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3502c, (MTV023.09c), len: 317 aa (start FT uncertain). Probable short-chain dehydrogenase/reductase FT (EC 1.-.-.-), similar to Mycobacterium tuberculosis FT proteins P71853|Rv3548c|MTCY03C7.08 HYPOTHETICAL 31.1 KDA FT PROTEIN (304 aa), FASTA scores: opt: 739, E(): 6.2e-35, FT (45.15% identity in 310 aa overlap); and FT Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE FT OXIDOREDUCTASE (247 aa), FASTA scores: opt: 475, E(): FT 5.1e-20, (40.15% identity in 254 aa overlap). Also similar FT to various dehydrogenases e.g. Q9I4V1|PA1023 PROBABLE FT SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (305 FT aa), FASTA scores: opt: 535, E(): 2.3e-23, (37.1% identity FT in 302 aa overlap); Q9UVH9|FOX2 FOX2 PROTEIN (SDR FAMILY) FT (1015 aa), FASTA scores: opt: 487, E(): 3.2e-20, (38.4% FT identity in 276 aa overlap); P22414|FOX2_CANTR PEROXISOMAL FT HYDRATASE-DEHYDROGENASE, D-3-HYDROXYACYL CoA DEHYDROGENASE FT (EC 1.1.1.-) (SDR FAMILY) from Candida tropicalis (Yeast) FT (906 aa) FASTA scores: opt: 481, E(): 6.4e-20, (38.0% FT identity in 250 aa overlap); FT P50171|DHB8_MOUSE|HSD17B8|HKE6|H2-KE6 ESTRADIOL 17 FT BETA-DEHYDROGENASE 8 from Mus musculus (Mouse) (260 aa) FT FASTA scores: opt: 459, E(): 4.3e-19, (39.75% identity in FT 259 aa overlap); CAC41362|BKR1 3-OXYACYL-[ACYL-CARRIER FT PROTEIN] REDUCTASE (EC 1.1.1.100) (FRAGMENT) from Brassica FT napus (Rape) (317 aa), FASTA scores: opt: 447, E(): FT 2.4e-18, (39.2% identity in 255 aa overlap); etc. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is FT 0.880." FT /db_xref="GOA:O53547" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O53547" FT /protein_id="CAA17739.1" FT /translation="MKLTESNRSPRTTNTTDLSGKVAVVTGAAAGLGRAEALGLARLGA FT TVVVNDVASALDASDVVDEIGAAAADAGAKAVAVAGDISQRATADELLASAVGLGGLDI FT VVNNAGITRDRMLFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRDKAKDAEGGSVFGRL FT VNTSSEAGLVGPVGQANYAAAKAGITALTLSAARALGRYGVCANVICPRARTAMTADVF FT GAAPDVEAGQIDPLSPQHVVSLVQFLASPAAAEVNGQVFIVYGPQVTLVSPPHMERRFS FT ADGTSWDPTELTATLRDYFAGRDPEQSFSATDLMRQ" FT misc_feature complement(104277..104363) FT /note="PS00061 Short-chain dehydrogenases/reductases family FT signature." FT CDS complement(104889..105080) FT /transl_table=11 FT /gene="fdxD" FT /locus_tag="Rv3503c" FT /product="PROBABLE FERREDOXIN FDXD" FT /function="FERREDOXINS ARE IRON-SULFUR PROTEINS THAT FT TRANSFER ELECTRONS IN A WIDE VARIETY OF METABOLIC FT REACTIONS." FT /note="Rv3503c, (MTV023.10c), len: 63 aa. Probable fdxD, FT ferredoxin, equivalent to Q9R6Z5|B229_C3_226 HYPOTHETICAL FT 9.3 KDA PROTEIN from Mycobacterium leprae (83 aa) FASTA FT scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa FT overlap). Also similar to several e.g. Q9R6Z5|PHDC from FT Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: FT 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); FT Q9X4X8|DITA3 DIOXYGENASE DITA FERREDOXIN COMPONENT from FT Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166, FT E(): 1.4e-05, (36.2% identity in 58 aa overlap); FT P00203|FER_MOOTH from Moorella thermoacetica (Clostridium FT thermoaceticum) (63 aa), FASTA scores: opt: 157, E(): FT 5.4e-05, (36.65% identity in 60 aa overlap); FT P18325|FER2_STRGO|SUBB from Streptomyces griseolus (64 aa) FT FASTA scores: opt: 157, E(): 5.5e-05, (39.35% identity in FT 61 aa overlap); etc. BELONGS TO THE BACTERIAL TYPE FT FERREDOXIN FAMILY. TBparse score is 0.871." FT /db_xref="GOA:O53548" FT /db_xref="HSSP:1VJW" FT /db_xref="InterPro:IPR001080" FT /db_xref="UniProtKB/TrEMBL:O53548" FT /protein_id="CAA17740.1" FT /translation="MRVIVDRDRCEGNAVCLGIAPDIFDLDDEDYAVVKTDPIPVDQED FT LAEQAIAECPRAALSRGE" FT CDS 105295..106497 FT /transl_table=11 FT /gene="fadE26" FT /locus_tag="Rv3504" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE26" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv3504, (MTV023.11), len: 400 aa. Probable fadE26, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other FT ACYL-CoA DEHYDROGENASES from Mycobacterium tuberculosis FT e.g. P71858|FADE29|Rv3543c|MTCY03C7.13 (387 aa) FASTA FT scores: opt: 1031, E(): 7.5e-59, (46.25% identity in 402 aa FT overlap); and P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FT FASTA scores: opt: 617, E(): 3.1e-32, (32.6% identity in FT 423 aa overlap); etc. Also similar to others e.g. FT Q9A6G3|CC2131 from Caulobacter crescentus (403 aa) FASTA FT scores: opt: 710, E(): 3.2e-38, (33.4% identity in 413 aa FT overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 FT aa), FASTA scores: opt: 522, E(): 3.7e-26, (34.1% identity FT in 358 aa overlap); Q9RJX2|SCF37.29c from Streptomyces FT coelicolor (393 aa), FASTA scores: opt: 509, E(): 2.6e-25, FT (34.45% identity in 363 aa overlap); etc. COULD BELONG TO FT THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is FT 0.885." FT /db_xref="GOA:O53549" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006091" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:O53549" FT /protein_id="CAA17741.1" FT /translation="MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNVY FT RETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFLTINSVAPTIMA FT YGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSL FT IQYADYVWLAVRTNPESSGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSATYYSDV FT RVPVANRVGEENAGWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGGTRLID FT SEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGTELATEAYRL FT LMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGMVALGLPRAN FT R" FT CDS 106522..107643 FT /transl_table=11 FT /gene="fadE27" FT /locus_tag="Rv3505" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE27" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv3505, (MTV023.12), len: 373 aa. Probable fadE27, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other FT ACYL-CoA DEHYDROGENASES from Mycobacterium tuberculosis FT e.g. P71857|FADE28|Rv3544c|MTCY03C7.12 (339 aa) FASTA FT scores: opt: 497, E(): 1.8e-22, (30.3% identity in 343 aa FT overlap); and P95281|FADE18|Rv1933c|MTCY09F9.31 (363 aa) FT FASTA scores: opt: 421, E(): 6.4e-18, (32.35% identity in FT 334 aa overlap). Also similar to other e.g. Q9A5G8|CC2479 FT from Caulobacter crescentus (344 aa), FASTA scores: opt: FT 425, E(): 3.5e-18, (30.75% identity in 351 aa overlap); FT Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa) FT FASTA scores: opt: 317, E(): 1e-11, (32.8% identity in 372 FT aa overlap); Q9L8Q3|PDTORFO from Pseudomonas stutzeri FT (Pseudomonas perfectomarina) (513 aa), FASTA scores: opt: FT 301, E(): 1.2e-10, (25.9% identity in 394 aa overlap); etc. FT COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse FT score is 0.888." FT /db_xref="GOA:O53550" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:O53550" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17742.1" FT /translation="MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELWR FT KLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLAAGALARFGSP FT ELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGTGHGYRLTGTRTQVGYGPVADAFLV FT PAETDSGAAVFLVAAGDPGVAVTALATTGLGSVGHLELNGAKVDAARRVGGTDVAVWLG FT TLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLT FT LTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDTDHPV FT HRYFLAAKQTEFALGGATGQLRRIGRELAETPA" FT CDS 107714..109222 FT /transl_table=11 FT /gene="fadD17" FT /locus_tag="Rv3506" FT /product="POSSIBLE FATTY-ACID-CoA SYNTHETASE FADD17 FT (FATTY-ACID-CoA SYNTHASE) (FATTY-ACID-CoA LIGASE)" FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID FT DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv3506, (MTV023.13), len: 502 aa. Possible fadD17, FT fatty-acid-CoA synthetase (ligase) (EC 6.2.1.-), similar to FT P72007|FADD1|RV1750c|MTCY28.13c|MTCY04C12.34 from FT Mycobacterium tuberculosis (532 aa), FASTA scores: opt: FT 666, E(): 9.8e-32, (52.05% identity in 488 aa overlap). FT Also similar to various ligases/synthetases e.g. Q9EY88|FCS FT FERULOYL-CoA SYNTHETASE from Amycolatopsis sp. HR167 (491 FT aa), FASTA scores: opt: 490, E(): 2.1e-21, (30.3% identity FT in 462 aa overlap); BAB33463|ECS0040 (alias AAG54340|CAIC) FT PROBABLE CROTONOBETAINE/CARNITINE-CoA LIGASE from FT Escherichia coli strain O157:H7 (522 aa), FASTA scores: FT opt: 478, E(): 1.1e-20, (28.5% identity in 347 aa overlap); FT Q9KHL1|ENCH PUTATIVE ACYL-CoA LIGASE from Streptomyces FT maritimus (535 aa), FASTA scores: opt: 477, E(): 1.3e-20, FT (28.7% identity in 453 aa overlap); Q50017|XCLC|ML1051 FT ACYL-CoA SYNTHASE from Mycobacterium leprae (476 aa), FASTA FT scores: opt: 472, E(): 2.3e-20, (31.35% identity in 469 aa FT overlap); P31552|CAIC_ECOLI|B0037 from Escherichia coli FT strain K12 (522 aa), FASTA scores: opt: 467, E(): 4.8e-20, FT (28.75% identity in 348 aa overlap); Q9KBC2|BH2006 from FT Bacillus halodurans LONG-CHAIN ACYL-CoA SYNTHETASE (LIGASE) FT (513 aa), FASTA scores: opt: 462, E(): 9.4e-20, (27.65% FT identity in 463 aa overlap); etc. Contains PS00455 Putative FT AMP-binding domain signature. TBparse score is 0.898." FT /db_xref="GOA:O53551" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="InterPro:IPR020845" FT /db_xref="UniProtKB/TrEMBL:O53551" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17743.1" FT /translation="MTPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAA FT LRERLDPARPPHVGVLLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKADCQ FT LVLTGSGSAEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGTSGD FT PKAVKCSHRKVAIAGVTITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALR FT RKFSASQFLADVRRYGATYANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPGDIDR FT FGRRFGCVVMDGFGSTEGGVAITRTLDTPAGALGPLPGGIQIVDPDTGEPCPTGVVGEL FT VNTAGPGGFEGYYNDEAAEAERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWMRVDGENL FT GTAPIERVLMRYPDATEVAVYPVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDL FT GHKQWPSYVRVSAGLPRTMTFKVIKRQLSAEGVACADPVWPIRR" FT misc_feature 108173..108208 FT /note="PS00455 Putative AMP-binding domain signature." FT CDS 109393..113538 FT /transl_table=11 FT /gene="PE_PGRS53" FT /locus_tag="Rv3507" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3507, (MTV023.14), len: 1381 aa. Member of the FT Mycobacterium tuberculosis PE protein family, PGRS FT subfamily of gly-rich proteins (see citation below), FT similar to others from Mycobacterium tuberculosis strains FT H37Rv and CDC1551 e.g. O06810|Rv1450c|MTCY493.04 (1329 aa), FT FASTA scores: opt: 2173, E(): 1.4e-135, (51.15% identity in FT 1412 aa overlap). Equivalent to AAK47970 from Mycobacterium FT tuberculosis strain CDC1551 (1384 aa) but with some minor FT differences between the proteins. Contains two PS00583 pfkB FT family of carbohydrate kinases signatures 1." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q6MWW9" FT /protein_id="CAE55603.1" FT /translation="MSFVLVSPETVAAVATDLKRIGASLAHENASAAASTTAVVSAAAD FT EVSTAVAALFSQHAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFAEAANASPLQSAMGA FT VSASAQTLLSRPLIGNGANATTPGGNGGDGGWLFGSGGNGAPGAAGQSGGNGGSAGLWG FT NGGAGGAGGSGGAAGGNGGNGGWLFGAGGTGGIGGTGAPGAMGGTGGNGGNGALLIGGG FT GLGGAGGMGGTGGGTGGTGGNGGNGALLIGAGGVGGAGGIGGQGTGAGGAAGAGGTGGN FT GGAGGLFMNGGDGGAGGQGGDGAAGDAAASAGGTGGKGGQGGDGGTGGAGGAGPVLFGH FT GGAGGMGGQGGTGGMGGAGGDGTTVIAAGTGGEGGTGGAAGAGGAAGARGALTSGGLAG FT GVGAGGTGGTGGTGGNGADAAAVVGFGANGDPGFAGGKGGNGGIGGAAVTGGVAGDGGT FT GGKGGTGGAGGAGNDAGSTGNPGGKGGDGGIGGAGGAGGAAGTGNGGHAGNTGDGGDGG FT TGGNGGNGTGGVNGADNTLNPDTPGGAGEPGGAGGAGGAGGAAGGPGGTGGTGGNGGNG FT GNGGNGGNGGNGGNGGNAGNNSTNAPVGGEGGAGGDGGAGGAGGAANGGTAGSQGTGGV FT GGDGGAGGNGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVGGAAGANGGTGGSGGNGG FT DGGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGGNAGGAGGQGGNAGQGG FT AGGAGGNAVIPGDGVGKAPHGDAGGSGGDGGKGGQGGSGGTGGSGAPIGGGAGGTGGSG FT GHAGKGGAGGIGAQGTTITVPGNGGNAGDGGNGGNAGAGGNGGSGDFGGNTTSGASGSG FT GNGGNAGTAGSGGAGGTGGTGLSGGNGGNGGNGGNGGDGGNGAHGTVGAQFVPATSLPT FT PNGGAGGNGGTGSNGGAPGPAGAPGPTTGGNAGSQGIGGDGGNGGDGGKGGDGADAVNV FT VFMPTEPQAATGTAGSAGDPTGGNGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTGS FT TNANDGTATGGKGGEGGVGSILGGPGGNGGTGGNASATGTNGVANAGNGGKGGDGGQFG FT AGGNGGAGGSVTDGSAGSTAGNGGNGGNATNGTIAGQPAGGNGSAGGKGGDGGNIAAGA FT TGTAGNGGNGGNGNDGAVNAGTGGSGGNGGNAGGGGANGGDGGAGGAGGAGGRGGKGID FT GGFGGDGGNGGSNNGTGAGGNGGNGGTGGVGSVGAAGGDGGNGGTGGFAGFGGTAGNGG FT SGGTGGAGGDGGTGGDGGNGVIAGGGGTGGNGGASGAGGAGGTGGFAGNGNAGGNGGTG FT GASEDGDNGNAGSGATGGTGGNGGTGGDGGAAGLGGVA" FT misc_feature 110791..110865 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT misc_feature 112789..112863 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT CDS 113829..119534 FT /transl_table=11 FT /gene="PE_PGRS54" FT /locus_tag="Rv3508" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3508, (MTV023.15), len: 1901 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see Brennan & Delogu 2002), similar to FT others from Mycobacterium tuberculosis strains H37Rv and FT CDC1551 e.g. downstream O53559|Rv3514|MTV023.21 (1489 aa), FT FASTA scores: opt: 6598, E(): 0, (71.05% identity in 1533 FT aa overlap). Equivalent to AAK47971 from Mycobacterium FT tuberculosis strain CDC1551 (1384 aa) but shorter 13 aa and FT with some minor differences between the proteins. Contains FT five PS00583 pfkB family of carbohydrate kinases signatures FT 1." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:O53553" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55604.1" FT /translation="MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGAD FT EVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAAAAEQIVLGVIN FT APTQALLGRPLIGDGANATTPGGAGGAGGLLFGNGGAGAAGAPGQAGGPGGPAGLWGNG FT GPGGAGGSGGGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVGG FT AGGGTGGAGGRAELLFGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGAGGAGG FT QGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGGTGGAGG FT DGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSAGGAAGAVGVGGTGGQGGAGGAGAA FT GADAPASTGLTGGTGFAGGAGGVGGQGGNAIAGGINGSGGAGGTGGQGGAGGMGGSGAD FT NASGIGADGGAGGTGGNAGAGGAGGAAGTGGTGGVVGAAGKAGIGGTGGQGGAGGAGSA FT GTDATATGATGGTGFSGGAGGAGGAGGNTGVGGTNGSGGQGGTGGAGGAGGAGGVGADN FT PTGIGGTGGTGGKGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQGGAGGAGGAGADNPTG FT IGGAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSVGNAGIGGTGGTGGVGGAGGAGAAA FT AAGSSATGGAGFAGGAGGEGGAGGNSGVGGTNGSGGAGGAGGKGGTGGAGGSGADNPTG FT AGFAGGAGGTGGAAGAGGAGGATGTGGTGGVVGATGSAGIGGAGGRGGDGGDGASGLGL FT GLSGFDGGQGGQGGAGGSAGAGGINGAGGAGGNGGDGGDGATGAAGLGDNGGVGGDGGA FT GGAAGNGGNAGVGLTAKAGDGGAAGNGGNGGAGGAGGAGDNNFNGGQGGAGGQGGQGGL FT GGASTTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGGDGGDAGSGGGGGFGGAA FT GKAGGGGNGGRGGDGGDGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGAGGAGGNGG FT DGGDGATGAAGLGDNGGVGGDGGAGGAAGNGGNAGVGLTAKAGDGGAAGNGGNGGAGGA FT GGAGDNNFNGGQGGAGGQGGQGGLGGASTTSINANGGAGGNGGTGGKGGAGGAGTLGVG FT GSGGTGGDGGDAGSGGGGGFGGAAGKAGGGGNGGVGGDGGEGASGLGLGLSGFDGGQGG FT QGGAGGSAGAGGINGAGGAGGTGGAGGDGAPATLIGGPDGGDGGQGGIGGDGGNAGFGA FT GVPGDGGDGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDPSIDGGQGGAGGHGGQGG FT KGGLNSTGLASAASGDGGNGGAGGAGGNGGDGDGFIGGSGGTGGTGGDAGVGGLANTGG FT TAGNAGIGGAGGRGGDGGAGDSGALSQDGNGFAGGQGGQGGVGGNAGAGGINGAGGTGG FT TGGAGGDGQNGTTGVASEGGAGGQGGDGGQGGIGGAGGNAGFGAGVPGDGGIGGTGGAG FT GAGGAGADGDPSIDGGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGD FT GDGFIGGSGGTGGTGGDAGVGGLANTGGTAGNAGIGGAGGRGGDGGAGDSGALSQDGNG FT FAGGQGGQGGVGGNAGAGGINGAGGTGGTGGAGGDGQNGTTGVASEGGAGGQGGDGGQG FT GIGGAGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDPSIDGGQGGAGGHGGQGGKGG FT LNSTGLASAASGDGGNGGAGGAGGNGGAGGLGGGGGTGGTNGNGGLGGGGGNGGAGGAG FT GTPTGSGTEGTGGDGGDAGAGGNGGSATGVGNGGNGGDGGNGGDGGNGAPGGFGGGAGA FT GGLGGSGAGGGTDGDDGNGGSPGTDGS" FT misc_feature 115119..115190 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT misc_feature 115638..115709 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT misc_feature 118224..118298 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT misc_feature 118839..118913 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT misc_feature 119397..119471 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT CDS complement(119701..121248) FT /transl_table=11 FT /gene="ilvX" FT /locus_tag="Rv3509c" FT /product="PROBABLE ACETOHYDROXYACID SYNTHASE ILVX FT (ACETOLACTATE SYNTHASE)" FT /function="COULD BE INVOLVED IN VALINE AND ISOLEUCINE FT BIOSYNTHESIS (AT THE FIRST STEP) [CATALYTIC ACTIVITY: FT 2-ACETOLACTATE + CO(2) = 2 PYRUVATE]." FT /EC_number="2.2.1.6" FT /note="Rv3509c, (MTV023.16), len: 515 aa. Probable ilvX, FT acetohydroxyacid synthase (EC 4.1.3.18), equivalent to FT Mycobacterium leprae protein described as Acetolactate FT synthase I, valine sensitive, large subunit (EC 4.1.3.18) FT Q49865|ILVX|ILVI1|B229_C3_222 (515 aa), FASTA scores: opt: FT 2762, E(): 8.8e-145, (82.9% identity in 515 aa overlap). FT Also similar to various enzymes (principally FT acetohydroxyacid/acetolactate synthases) e.g. Q9AB41|CC0393 FT THIAMINE-PYROPHOSPHATE-REQUIRING ENZYME from Caulobacter FT crescentus (512 aa), FASTA scores: opt: 1572, E(): 2.8e-79, FT (50.95% identity in 514 aa overlap); BAB50432|MLL3567 FT ACETOLACTATE SYNTHASE I from Rhizobium loti (Mesorhizobium FT loti) (517 aa), FASTA scores: opt: 1440, E(): 5.2e-72, FT (47.9% identity in 548 aa overlap); P20906|MDLC_PSEPU FT BENZOYLFORMATE DECARBOXYLASE (EC 4.1.1.7) from Pseudomonas FT putida (528 aa), FASTA scores: opt: 356, E(): 2.5e-12, FT (28.1% identity in 530 aa overlap); Q9L123|SC6D11.33c FT PUTATIVE DECARBOXYLASE from Streptomyces coelicolor (526 FT aa), FASTA scores: opt: 325, E(): 1.3e-10, (33.2% identity FT in 530 aa overlap); Q9RDF9|SCC57A.40c PUTATIVE ACETOLACTATE FT SYNTHASE from Streptomyces coelicolor (564 aa), FASTA FT scores: opt: 304, E(): 1.9e-09, (28.55% identity in 550 aa FT overlap); P94783 VALINE-SENSITIVE ACETOHYDROXY ACID FT SYNTHASE from Citrobacter freundii (561 aa), FASTA scores: FT opt: 278, E(): 5.1e-08, (25.8% identity in 550 aa overlap); FT Q42767|AHAS ACETOHYDROXYACID SYNTHASE (EC 4.1.3.18)from FT Gossypium hirsutum (Upland cotton) (659 aa), FASTA scores: FT opt: 278, E(): 5.8e-08, (26.15% identity in 558 aa FT overlap); etc. Note that other Mycobacterium tuberculosis FT proteins, e.g. FT O53250|MTV012.17c|ILVB_MYCTU|Rv3003c|MT3083|MTV012.17c, FT show better similarity to Acetolactate synthase I. SIMILAR FT TO OTHER ENZYMES WHICH REQUIRE TPP. COFACTOR: THIAMIN FT PYROPHOSPHATE (BY SIMILARITY). TBparse score is 0.902." FT /db_xref="GOA:O53554" FT /db_xref="HSSP:1JSC" FT /db_xref="InterPro:IPR011766" FT /db_xref="InterPro:IPR012001" FT /db_xref="UniProtKB/TrEMBL:O53554" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17746.1" FT /translation="MNGAQALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLT FT LFEGVATGAADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH FT KKYDAPLESDIDAVAGTVSGWVRRTEAAADVGADAEAAIAASRSGSQIATLILPADVCW FT SDGAHAAAGVPAQAAAAPVDVGPVAGVLRSGEPAMMLIGGDATRGPGLTAAARIVQATG FT ARWLCETFPTCLERGAGIPAVERLAYFAEGAAAQLDGVKHLVLAGARSPVSFFAYPGMP FT SDLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVAGASRPQLPTGDLTSVSAADV FT VGALLPERAIVVDESNTCGVLLPQATAGAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDR FT PVLCLESDGSAMYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAGSDPGPKAL FT DLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPGPHLIDVVVPSLVG" FT CDS complement(121245..122081) FT /transl_table=11 FT /locus_tag="Rv3510c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3510c, (MTV023.17), len: 278 aa. Conserved FT hypothetical protein, similar to Q50662|Rv2303c|MTCY339.06 FT HYPOTHETICAL 34.6 KDA PROTEIN from Mycobacterium FT tuberculosis (307 aa), FASTA scores: opt: 416, E(): FT 1.2e-19, (35.7% identity in 255 aa overlap). Middle of the FT putative protein highly similar to N-terminal end of FT Q49860|B229_C2_182 HYPOTHETICAL 11.0 KDA PROTEIN from FT Mycobacterium leprae (95 aa), FASTA scores: opt: 304, E(): FT 7.9e-13, (83.65% identity in 55 aa overlap). Also some FT similarity with other bacterial proteins e.g. P95886 ORF FT C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: FT opt: 293, E(): 9.6e-12, (31.3% identity in 198 aa overlap); FT Q9XDF3|NONC NONC PROTEIN from Streptomyces griseus subsp. FT griseus (317 aa), FASTA scores: opt: 270, E(): 3.4e-10, FT (29.95% identity in 227 aa overlap); Q54229|NONR FT MACROTETROLIDE ANTIBIOTIC-RESISTANCE PROTEIN from FT Streptomyces griseus (347 aa), FASTA scores: opt: 270, E(): FT 3.6e-10, (29.95% identity in 227 aa overlap); etc. TBparse FT score is 0.907." FT /db_xref="GOA:O53555" FT /db_xref="InterPro:IPR006992" FT /db_xref="UniProtKB/TrEMBL:O53555" FT /protein_id="CAA17747.1" FT /translation="MTIDVWMQHPTQRFLHGDMFASLRRWTGGSIPETDIPIEATVSSM FT DAGGVTLGLLSAWRGPNGQDLISNDAVAEWVRLYPNRFAGLAAVDLDRPMAAVRELRRR FT VGEGFVGLRVVPWLWGAPPTDRRYYPLFAECVQSAVPFCTQVGHTGPLRPSETGRPIPY FT IDQVALDFPELVIVCGHVGYPWTEEMVAVARKHENVYIDTSAYTIKRLPGKLVRFMKTD FT TGQRKVLFGTNYPMIAHTHALTGLDELGLSDEARRDFLHGNAVRVFKLDPRGKVQT" FT CDS 122441..124585 FT /transl_table=11 FT /gene="PE_PGRS55" FT /locus_tag="Rv3511" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3511, (MTV023.18), len: 714 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to others FT from Mycobacterium tuberculosis strains H37Rv and CDC1551 FT e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 2563, FT E(): 1.5e-94, (59.65% identity in 773 aa overlap); and FT upstream O53553|Rv3508|MTV023.15 (1901 aa), FASTA scores: FT opt: 2455, E(): 3.9e-90, (60.4% identity in 737 aa FT overlap); etc. Contains PS00583 pfkB family of carbohydrate FT kinases signature 1." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q6MWW8" FT /protein_id="CAE55605.1" FT /translation="MSFVLISPEVVSAAAGDLANVGSTISAANKAAAAATTQVLAAGAD FT EVSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYMLAEATNVEQNLLNLIN FT APTQTLLGRPLIGDGANATTPGGAGGDGGLLFGSGGNGAPGAPGQAGGAGGSAGLLGNG FT GSGGAGGTGAPGGNGGNAGWLYGRGGVGGAGGIGGGTGGAGGHAWLFGHGGTGGIGGGP FT GGNGGWLLGNGGHGGAGGIGGGSGGAGGNGGWLLGNGGIGGAGGTGGGAGGTGGNAAWL FT LGGGGTGGAGGIGGGNGGHGGNGGWLLGNGGNGGLGGDGDGGTGGGHGGNGGNPGWLLG FT TAGGGGNGGAGSTGTAGGGSGGTGGDGGTGGRGGLLMGAGAGGHGGTGGAGGAGVNGGG FT AGGAGGAGGNGGAGGQAALLFGRGGTGGAGGYGGDGGGGGDGFDGTMAGLGGTGGSGGT FT GGDGGAPGNGGAGGAGQLLSHSGVAGASGKGGAGGTGGNGGAGSAGADAPAGSGAMGST FT GFAGGAGGDGGNGGGSGASQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGT FT GGTGGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAG FT GTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGN FT AGAGGTGFTPRRRRQRRQRR" FT misc_feature 123254..123328 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT CDS <124548..127787 FT /transl_table=11 FT /gene="PE_PGRS56" FT /locus_tag="Rv3512" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3512, (MTV023.19), len: 1059 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to others FT from Mycobacterium tuberculosis strains H37Rv and CDC1551 FT e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 3688, FT E(): 4.5e-130, (53.95% identity in 1136 aa overlap); and FT downstream O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: FT opt: 3611, E(): 3.6e-127, (53.15% identity in 1195 aa FT overlap); etc. Frameshifted PGRS protein, could be FT continuation of upstream MTV023.18, but no error could be FT found." FT /db_xref="UniProtKB/TrEMBL:Q6MWW7" FT /protein_id="CAE55606.1" FT /translation="PQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAG FT GTGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGDAGK FT AGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGGTGGSGGAGGTGGDGGAANG FT GTAGAGGAGGNGGKGGDGGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAGATPGANGIAG FT NGGDGGDGAAGAVGISGATGAGDGGHGGTGAAGGNGGTGGAGGSGIDGVGGGTGGTGGN FT GGNGAIGGAGGDAGGSGNSGGNGGIGGKGGNAGAGGAAGSNGGTVGANGTGGDGGNGGA FT AGAATAGSNGGAGTGSAGGNGGTGGRGGSGGAGGDGIGGVGGGKGGNGADGEVGGAGGA FT GGSGPNTSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGAGGTGGAGAAS FT SATNGGSGGAGGTGGDGGSGGAGGTGGAGGTGGAAGDGGQGGQGGAGGGAGGQGGAGGA FT GGTGGNGGNITGGTAGTAGAAGNGGAAGKGGAGGQGGTGGGTGGQGGAGGDGGAGGTGG FT DRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGGDGGDAGTGGNGGNGGNRNSGNG FT TGGAGGNGGGGANGGAGGAGGSGGGTGGNGGAGGDAGDAGNGGNGNGTGNGGNGGNGGI FT AGMGGNGGAGTGSGNGGNGGSGGNGGNAGMGGNSGTGSGDGGAGGNGGAAGTGGTGGDG FT GLTGTGGTGGSGGTGGDGGNGGNGADNTANMTAQAGGDGGNGGDGGFGGGAGAGGGGLT FT AGANGTGGQGGAGGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTGGTGGAGIGSLGGGTG FT GDGGNGGNGGTGGEGGEVGGAGGTGGAAGNGGDGGTGGTGGGDGGAGGTGGTGGTGGLG FT DPRVGGSGGDGGTGGSGGAAGNGGNGGNAGAGGNGNGGTGGAGGIGGTGGNGGDAEPGV FT PPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTGGDGGTGGGGGNGGTGWNGGKGDTGSGG FT GAGDGGKAPAGGTGGAGGDGGAGGKGGSGGV" FT CDS complement(127916..128572) FT /transl_table=11 FT /gene="fadD18" FT /locus_tag="Rv3513c" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv3513c, (MTV023.20c), len: 218 aa (Start FT uncertain). Probable fadD18, fatty-acid-CoA synthetase FT (C-terminal fragment) (EC 6.2.1.-), almost identical to FT C-terminal end of downstream FT O53560|FADD19|Rv3515c|MTV023.22c, probably result of FT partial gene duplication. Also similar at the C-terminus to FT other fatty-acid-CoA synthetases e.g. Q9EXL2|FADD from FT Streptomyces griseus (540 aa), FASTA scores: opt: 586, E(): FT 1.2e-28, (52.45% identity in 185 aa overlap); AAB87139|MIG FT MEDIUM CHAIN ACYL-CoA SYNTHETASE PRECURSOR from FT Mycobacterium avium (550 aa), FASTA scores: opt: 506, E(): FT 9.5e-24, (50.0% identity in 150 aa overlap); Q9A7C3|CC1801 FT PUTATIVE 4-COUMARATE--CoA LIGASE from Caulobacter FT crescentus (561 aa), FASTA scores: opt: 430, E(): 4.4e-19, FT (45.75% identity in 153 aa overlap); Q9KDT0|BH1131 ACID-CoA FT LIGASE from Bacillus halodurans (546 aa), FASTA scores: FT opt: 338, E(): 1.9e-13, (38.05% identity in 142 aa FT overlap); Q9RTR4|DR1692 LONG-CHAIN FATTY ACID--CoA LIGASE FT from Deinococcus radiodurans (584 aa), FASTA scores: opt: FT 331, E(): 5.3e-13, (35.15% identity in 145 aa overlap); FT etc." FT /db_xref="GOA:O53558" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:O53558" FT /protein_id="CAA17750.1" FT /translation="MAASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAV FT RPARTLAKKGNIPVGYYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVS FT INSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDS FT FVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS" FT repeat_region complement(127922..128421) FT /note="500 bp perfect direct repeat 2; second copy at FT 3950830..3951329." FT CDS 128618..133087 FT /transl_table=11 FT /gene="PE_PGRS57" FT /locus_tag="Rv3514" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3514, (MTV023.21), len: 1489 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to others FT from Mycobacterium tuberculosis strains H37Rv and CDC1551 FT e.g. AAK47971 (1715 aa) FASTA scores: opt: 6940, E(): 0, FT (67.0% identity in 1713 aa overlap); and upstream FT O53553|YZ08_MYCTU|Rv3508|MTV023.15 (1901 aa), FASTA scores: FT opt: 6598,E(): 0, (71.05% identity in 1533 aa overlap). FT Contains two PS00583 pfkB family of carbohydrate kinases FT signatures 1. TBparse score is 0.838." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q6MWW6" FT /protein_id="CAE55607.1" FT /translation="MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGAD FT EVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAAAAEQIVLGVIN FT APTQALLGRPLIGDGANATTPGGAGGAGGLLFGNGGAGAAGAPGQAGGPGGPAGLWGNG FT GPGGAGGSGGGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVGG FT AGGGTGGAGGRAELLFGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGAGGAGG FT QGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGGTGGAGG FT DGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSASGAAGNAGVGGAGGQGGDGGAGGA FT GADADQPGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGQGGAGGAGGAGADNPTG FT IGGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGQGGDGGAGGAGADA FT DQPGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGTGGQGGAGGAGGAGADNPTGI FT GGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGQGGDGGAGGAGADAD FT QPGATGGTGFAGGAGGAGKAGGSSSAGGTNSSGSAGGTGRQSGTGGAGGAGADNPTGIG FT GTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGSSGAGGTNGSGGAGGT FT DGQGGAGGAGGAGADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGV FT GGAGGQGGDGGAGGAGADADQPGATGGTGFAGGAGGAGGSGGSSCAGGTNGSGGAGGTC FT GQVVAGGAGISFSNGSNGGTGGTGGVGGTGGDGGNAGTGAGDPGKGGTGGTGGTGGSGG FT AGGSGGANFNGGTGGTGGTGGKGGLNTDGLSSATSGTGGTGGTGGKGGTGGAGDDSAGG FT TGGTGGAGGNAGAGGLANTGGTAGNAGIGGDGGQGGNGGQGDSGSGLGGQPGFAGGAGG FT KGGAGGSSGAGGTNGSGGAGGAGGQGGAGGAGISFSNGSNGGTGGTGGVGGTGGDGGNA FT GTGAGDPGKGGTGGTGGTGGSGGAGGSGGANFNGGTGGTGGTGGTGGKGGMGGIAGDGG FT PGGDGGNAGVGGKGGTNGNGGSGGTGGTGGAGGNAGAGGLANTGGTAGNAGIGGDGGQG FT GNGGQGDSGSGLGGQPGFAGGPGGKGGAGGNAGTGGTNGSGAGGAGGQGGAGGAGISFS FT NGSNGGTGGTGGVGGTGGDGGNAGTGAGDPGKGGTGGTGGTGGSGGAGGSGGANFNGGT FT GGTGGTGGTGGKGGMGGIAGDGGPGGDGGNAGVGGKGGTNGNGGSGGTGGTGGPGGSGG FT APTGSGTGGKGGAGGDGGDGADGGAATGVGDGGDGGNGGNGGNGGTGVGSPGGLGGAGG FT TGGLGGAGAGGGADGDDGDDGQPGNNGS" FT misc_feature 130247..130318 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT misc_feature 130598..130669 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1." FT CDS complement(133648..135294) FT /transl_table=11 FT /gene="fadD19" FT /locus_tag="Rv3515c" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD19 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv3515c, (MTV023.22c), len: 548 aa. Probable fadD19, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar (or with FT similarity) to many e.g. Q9EXL2|FADD FADD PROTEIN from FT Streptomyces griseus (540 aa), FASTA scores: opt: 1449, FT E(): 1.5e-81, (46.0% identity in 535 aa overlap); FT AAB87139|MIG MEDIUM CHAIN ACYL-CoA SYNTHETASE PRECURSOR FT from Mycobacterium avium (550 aa), FASTA scores: opt: 1226, FT E(): 7.6e-68, (40.7% identity in 543 aa overlap); FT Q9A7C3|CC1801 PUTATIVE 4-COUMARATE--CoA LIGASE from FT Caulobacter crescentus (561 aa), FASTA scores: opt: 979, FT E(): 1.2e-52, (34.05% identity in 531 aa overlap); FT O28502|AF1772 LONG-CHAIN-FATTY-ACID--CoA LIGASE (FADD-7) FT from Archaeoglobus fulgidus (569 aa), FASTA scores: opt: FT 560, E(): 6.9e-27, (29.3% identity in 543 aa overlap); FT Q9A8N2|CC1321 LONG-CHAIN-FATTY-ACID--CoA LIGASE from FT Caulobacter crescentus (583 aa), FASTA scores: opt: 544, FT E(): 6.7e-26, (27.2% identity in 518 aa overlap); FT P29212|LCFA_ECOLI|FADD|OLDD|B1805 FT LONG-CHAIN-FATTY-ACID--CoA LIGASE from Escherichia coli FT strain K12 (561 aa), FASTA scores: opt: 460, E(): 4e-22, FT (26.3% identity in 567 aa overlap); etc. Contains PS00455 FT Putative AMP-binding domain signature. TBparse score is FT 0.883. Note that upstream MTV023.20c|Rv3513c|fadD18 is FT identical to C-terminal part of FADD19|Rv3515c|MTV023.22c FT (probably result of partial gene duplication)." FT /db_xref="GOA:Q7D5D8" FT /db_xref="InterPro:IPR000873" FT /db_xref="InterPro:IPR020845" FT /db_xref="UniProtKB/TrEMBL:Q7D5D8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55608.1" FT /translation="MAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAH FT HLIDQGVQKDDKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMV FT ALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGVEFYSAIAAGSPERDFGE FT RSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEFVKDEYDLAKAAAANPP FT MIRYPIPPMIHGATQSATWMALFSGQTTVLAPEFNADEVWRTIHKHKVNLLFFTGDAMA FT RPLVDALVKGNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT FT SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTA FT ETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVF FT DALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSLWFVDEVKRS FT PAGKPDYRWAKEQTEARPADDVHAGHVTSGG" FT repeat_region complement(133654..134153) FT /note="500 bp perfect direct repeat 1; second copy at FT 3945098..3945597." FT misc_feature complement(134749..134784) FT /note="PS00455 Putative AMP-binding domain signature." FT CDS 135368..136159 FT /transl_table=11 FT /gene="echA19" FT /locus_tag="Rv3516" FT /product="POSSIBLE ENOYL-CoA HYDRATASE ECHA19 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv3516, (MTV023.23), len: 263 aa. Possible echA19, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to other e.g. FT Q9ZHG2|ECHA1 from Rhodococcus fascians (275 aa) FASTA FT scores: opt: 613, E(): 6.4e-32, (45.15% identity in 259 aa FT overlap); P76082|PAAF_ECOLI|B1393 from Escherichia coli FT strain K12 (255 aa), FASTA scores: opt: 523, E(): 3.3e-26, FT (33.6% identity in 256 aa overlap); Q9I393|PA1629 from FT Pseudomonas aeruginosa (261 aa), FASTA scores: opt: 475, FT E(): 3.8e-23, (36.85% identity in 247 aa overlap); etc. FT Also similar to many carnitine racemases eg FT BAB52369|MLL6015 from Rhizobium loti (Mesorhizobium loti) FT (257 aa), FASTA scores: opt: 546, E(): 1.1e-27, (36.65% FT identity in 251 aa overlap). Similar to several putative FT enoyl-CoA hydratases from Mycobacterium tuberculosis, e.g. FT P96404|ECHA1|Rv0222|MTCY08D5.17 (262 aa), FASTA scores: FT opt: 630, E(): 5.1e-33, (44.5% identity in 254 aa overlap); FT and O53783|ECHA5|Rv0675|MTV040.03 (263 aa) FASTA scores: FT opt: 499, E(): 1.1e-24, (40.5% identity in 252 aa overlap). FT COULD BELONG TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. FT TBparse score is 0.862." FT /db_xref="GOA:O53561" FT /db_xref="HSSP:1MJ3" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:O53561" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17753.1" FT /translation="MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVD FT NDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSFKDGSYGPSRIDALLKGRRLTKPLI FT AAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTLACD FT LLLTGRHITAAEAKEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETEC FT MPENEAFKIDTQIGIKVFLSDDAKEGPRAFAEKRAPNFQNR" FT CDS 136255..137094 FT /transl_table=11 FT /locus_tag="Rv3517" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3517, (MTV023.24), len: 279 aa. Hypothetical FT protein, similar to several hypothetical mycobacterial FT proteins e.g. P71763|Rv1482c|MTCY277.03c from Mycobacterium FT tuberculosis strain H37Rv (339 aa) (alias AAK45794|MT1529 FT from Mycobacterium tuberculosis strain CDC1551 (292 aa) but FT longer) FASTA scores: opt: 1040, E(): 3.7e-60, (59.0% FT identity in 273 aa overlap); O07396|MAV346 from FT Mycobacterium avium (346 aa) FASTA scores: opt: 1018, E(): FT 1e-58, (57.2% identity in 278 aa overlap); FT O53421|Rv1073|MTV017.26 from Mycobacterium tuberculosis FT strain H37Rv (283 aa), FASTA scores: opt: 903, E(): FT 2.4e-51, (48.0% identity in 277 aa overlap); FT Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa) FT FASTA scores: opt: 158, E(): 0.0015, (41.8% identity in 55 FT aa overlap); etc. TBparse score is 0.910." FT /db_xref="UniProtKB/TrEMBL:O53562" FT /protein_id="CAA17754.1" FT /translation="MIEPFLGSEAIASGALTRHRLRSAYATIHPDVYVSPGADLTAWSR FT AQAAWLWSRRRGVIAGQSAAAMHGAKWVDARQAAELLYDHRRPPAGIHTWSDRVADDEI FT QPISGMNTTTPARTALDLARRYPVGKAVAAIDALARATDLKLADVEMLAERYRGSRGIR FT NARIALDLVDPGAESPRETWLRLLLIRAGFPRPQTQIPVYDEYGQLVAVIDMGWAGIKV FT GVDYEGDHHRTDRRTFNKDIKRAEALTELGWTDVRVTVEDTEGGIIWRVSAAWQRRT" FT CDS complement(137149..138345) FT /transl_table=11 FT /gene="cyp142" FT /locus_tag="Rv3518c" FT /product="PROBABLE CYTOCHROME P450 MONOOXYGENASE 142 FT CYP142" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv3518c, (MTV023.25c), len: 398 aa. Probable cyp142, FT cytochrome P450 monoxygenase (EC 1.14.-.-), member of FT Cytochrome P450 family and similar to many e.g. FT Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FT FASTA scores: opt: 798, E(): 2e-43, (36.7% identity in 403 FT aa overlap); P33271|CPXK_SACER|CYP107B1 from FT Saccharopolyspora erythraea (Streptomyces erythraeus) (405 FT aa), FASTA scores: opt: 725, E(): 9.1e-39, (37.1% identity FT in 407 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from FT Streptomyces coelicolor (411 aa), FASTA scores: opt: 691, FT E(): 1.3e-36, (37.2% identity in 317 aa overlap); etc. Also FT similar to FT Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from FT Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA FT scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa FT overlap). Equivalent to AAK47979 from Mycobacterium FT tuberculosis strain CDC1551 (372 aa) but longer 26 aa. FT Contains PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY. TBparse FT score is 0.891." FT /db_xref="GOA:O53563" FT /db_xref="InterPro:IPR001128" FT /db_xref="InterPro:IPR002397" FT /db_xref="InterPro:IPR017972" FT /db_xref="InterPro:IPR017973" FT /db_xref="UniProtKB/Swiss-Prot:O53563" FT /protein_id="CAA17755.1" FT /translation="MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAAST FT YQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEA FT SIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFL FT SSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDDELVM FT ETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMC FT RVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFC FT LGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG" FT misc_feature complement(137320..137349) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature." FT CDS 138374..139084 FT /transl_table=11 FT /locus_tag="Rv3519" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3519, (MTV023.26), len: 236 aa (start uncertain). FT Hypothetical unknown protein. The C-terminal end is highly FT similar to N-terminal end of AAK47980|MT3620 HYPOTHETICAL FT 7.8 KDA PROTEIN from Mycobacterium tuberculosis strain FT CDC1551 (73 aa), FASTA scores: opt: 279, E(): 9.4e-12, FT (95.65% identity in 46 aa overlap). TBparse score is FT 0.897." FT /db_xref="UniProtKB/TrEMBL:O53564" FT /protein_id="CAA17756.1" FT /translation="MPVSQHTIAGTVLTMPVRIRTANLHSAMFSVPADPAQRLIDYSGL FT RVCEYLPGKAIVMQMLVRYVDGDLGRYHEYGTAIMVNPPGTQRRGPRALTRAAAFIHHL FT PVDQVFTLEAGRTIWGFPKIMADFNVTDGRRFGFDVSADGRLIAGIEFSTGLPVPTLGW FT QMLKTYSHHDGVTREIPWEMKVSGLRARLGGARLRLGDHPYAKELASLGLPKRALLSQS FT AANVEMTFGDGHPI" FT CDS complement(139149..140192) FT /transl_table=11 FT /locus_tag="Rv3520c" FT /product="POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3520c, (MTV023.27c), len: 347 aa. Possible FT coenzyme F420-dependent oxidoreductase (EC 1.-.-.-), FT equivalent to Q9CCV8|ML0348 POSSIBLE COENZYME FT F420-DEPENDENT OXIDOREDUCTASE from Mycobacterium leprae FT (350 aa), FASTA scores: opt: 2029, E(): 9.1e-120, (86.85% FT identity in 342 aa overlap). Similar to many coenzyme FT F420-dependent enzymes (and other proteins) e.g. FT Q9AD98|SCI52.11c PUTATIVE ATP/GTP-BINDING PROTEIN from FT Streptomyces coelicolor (351 aa), FASTA scores: opt: 859, FT E(): 1.6e-46, (41.9% identity in 346 aa overlap); FT Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE from Streptomyces FT coelicolor (341 aa), FASTA scores: opt: 800, E(): 7.9e-43, FT (38.95% identity in 339 aa overlap); Q9ZA30|GRA-ORF29 FT PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces FT violaceoruber (343 aa), FASTA scores: opt: 354, E(): FT 6.7e-15, (34.2% identity in 336 aa overlap); Q49598|MER FT COENZYME F420-DEPENDENT FT N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from FT Methanopyrus kandleri (349 aa), FASTA scores: opt: 283, FT E(): 1.9e-10, (26.75% identity in 329 aa overlap); FT Q58929|MER|MJ1534 F420-DEPENDENT FT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from FT Methanococcus jannaschii (331 aa), FASTA scores: opt: 227, FT E(): 5.8e-07, (26.35% identity in 334 aa overlap); FT O27784|MTH1752 COENZYME F420-DEPENDENT N5,N10-METHYLENE FT TETRAHYDROMETHANOPTERIN REDUCTASE from Methanobacterium FT thermoautotrophicum (321 aa), FASTA scores: opt: 207, E(): FT 1e-05, (27.4% identity in 336 aa overlap); etc. Also FT similar to Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 FT HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium FT tuberculosis (340 aa), FASTA scores: opt: 313, E(): FT 2.5e-12, (28.0% identity in 311 aa overlap). TBparse score FT is 0.890." FT /db_xref="GOA:O53565" FT /db_xref="InterPro:IPR011251" FT /db_xref="InterPro:IPR016048" FT /db_xref="InterPro:IPR019951" FT /db_xref="UniProtKB/TrEMBL:O53565" FT /protein_id="CAA17757.1" FT /translation="MEAGMKLGLQLGYWGAQPPQNHAELVAAAEDAGFDTVFTAEAWGS FT DAYTPLAWWGSSTQRVRLGTSVIQLSARTPTACAMAALTLDHLSGGRHILGLGVSGPQV FT VEGWYGQRFPKPLARTREYIDIVRQVWARESPVTSAGPHYRLPLTGEGTTGLGKALKPI FT THPLRADIPIMLGAEGPKNVALAAEICDGWLPIFYSPRMAGMYNEWLDEGFARPGARRS FT REDFEICATAQVVITDDRAAAFAGIKPFLALYMGGMGAEETNFHADVYRRMGYTQVVDE FT VTKLFRSGRKDEAAEIIPDELVDDAVIVGDIDHVRKQMAVWEAAGVTMMVVTAGSAEQV FT RDLAALV" FT CDS 140345..141256 FT /transl_table=11 FT /locus_tag="Rv3521" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3521, (MTV023.28), len: 303 aa. Conserved FT hypothetical protein, similar to (although longer than) FT other conserved hypothetical proteins e.g. O29296|AF0966 FT from Archaeoglobus fulgidus (176 aa), FASTA scores: opt: FT 286, E(): 5.4e-11, (31.15% identity in 170 aa overlap); FT O30036|AF0203 from Archaeoglobus fulgidus (149 aa) FASTA FT scores: opt: 259, E(): 2.3e-09, (33.8% identity in 142 aa FT overlap); O29297|AF0965 from Archaeoglobus fulgidus (154 FT aa), FASTA scores: opt: 241, E(): 3.2e-08, (31.4% identity FT in 137 aa overlap); Q9Y995|APE2390 from Aeropyrum pernix FT (157 aa), FASTA scores: opt: 204, E(): 6.8e-06, (27.45% FT identity in 153 aa overlap); BAB60424|TVG1322512 from FT Thermoplasma volcanium (164 aa), FASTA scores: opt: 183, FT E(): 0.00015, (29.75% identity in 148 aa overlap); etc. FT Equivalent to AAK47982 from Mycobacterium tuberculosis FT strain CDC1551 (334 aa) but shorter 31 aa. TBparse score is FT 0.884." FT /db_xref="InterPro:IPR002878" FT /db_xref="UniProtKB/TrEMBL:O53566" FT /protein_id="CAA17758.1" FT /translation="MGPTLSRFFTALRARRIVGVRGSDGRVHVPPVEYDPVTYEPLSEM FT VPVSSVGTVASWTWQPEPLAGQPLDRPFAWALIKLDGADTLLMHAVDVGTAGPSAIHTG FT ARVHAHWADQPVGAITDIACFALGETAEPVAAHKTEDARDPVTMIVTPIQLEIQHTASH FT EESAYLRAIAQGKLVGARTGKTGKVYFPPHGADPATGKPTSEFVELPDKGTVTTFAIVN FT IPFLGQRIKPPYVAAYVLLDGADIPFLHLVSDVDAHQVRMGMRVEAVWKPRERWGLGID FT NIEYFRPTGEPDANYDTYKHHL" FT CDS 141272..142336 FT /transl_table=11 FT /gene="ltp4" FT /locus_tag="Rv3522" FT /product="POSSIBLE LIPID TRANSFER PROTEIN OR KETO ACYL-COA FT THIOLASE LTP4" FT /function="UNKNOWN; PROBABLY INVOLVED IN LIPID METABOLISM." FT /EC_number="2.3.1.16" FT /note="Rv3522, (MTV023.29), len: 354 aa. Possible ltp4, FT lipid carrier protein or keto acyl-CoA thiolase (EC FT 2.3.1.16), similar to several e.g. O30103|AF0134 FT 3-KETOACYL-CoA THIOLASE (ACAB-4) from Archaeoglobus FT fulgidus (398 aa) FASTA scores: opt: 352, E(): 5.3e-15, FT (30.45% identity in 381 aa overlap); O29295|AF0967 FT 3-KETOACYL-CoA THIOLASE (ACAB-9) from Archaeoglobus FT fulgidus (400 aa) FASTA scores: opt: 312, E(): 1.8e-12, FT (28.05% identity in 367 aa overlap); O29294|AF0968 FT 3-KETOACYL-CoA THIOLASE (ACAB-10) from Archaeoglobus FT fulgidus (388 aa), FASTA scores: opt: 293, E(): 2.9e-11, FT (25.9% identity in 309 aa overlap); O58409|PH0676 LONG FT HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN (ACETHYL FT CoA SYNTHETASE) (EC 6.2.1.-) from Pyrococcus horikoshii FT (389 aa), FASTA scores: opt: 292, E(): 3.3e-11, (25.8% FT identity in 368 aa overlap); Q9Y9A3|APE2382 LONG FT HYPOTHETICAL NON SPECIFIC LIPID-TRANSFER PROTEIN from FT Aeropyrum pernix (360 aa) FASTA scores: opt: 270, E(): FT 7.8e-10, (27.25% identity in 363 aa overlap); FT Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER FT PROTEIN from Aeropyrum pernix (400 aa), FASTA scores: opt: FT 258, E(): 4.9e-09, (26.45% identity in 306 aa overlap); FT etc. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). TBparse score is 0.896." FT /db_xref="GOA:O53567" FT /db_xref="InterPro:IPR002155" FT /db_xref="InterPro:IPR016039" FT /db_xref="UniProtKB/TrEMBL:O53567" FT /protein_id="CAA17759.1" FT /translation="MSVRDIAVVGFAHAPHVRRTDGTTNGVEMLMPCFAQLYDELGITK FT ADIGFWCSGSSDYLAGRAFSFISAIDSIGAVPPINESHVEMDAAWALYEAYIKLLTGEV FT DTALVYGFGKSSAGTLRRVLSRQTDPYTVAPLWPDSVSMAGLQARLGLDSGKWTHEQMA FT RVAFDSFTNARRVDSVEPPITVGELLARPFFADPLRRHDIAPITDGAAAVVLAADNRAR FT ELRENPAWITGIEHRIESPALGARDITESPSTKLAAKIATGGHTGDIDVAEIHGPFTHQ FT HLIVAEAIRIPGKTKVNPSGGPLAANPMFAAGLERIGFAAQHTWDGSARRVLAHATSGP FT ALQQNLVAVMEGRG" FT misc_feature 142133..142156 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT CDS 142353..143537 FT /transl_table=11 FT /gene="ltp3" FT /locus_tag="Rv3523" FT /product="PROBABLE LIPID CARRIER PROTEIN OR KETO ACYL-COA FT THIOLASE LTP3" FT /function="UNKNOWN; PROBABLY INVOLVED IN LIPID METABOLISM." FT /EC_number="2.3.1.16" FT /note="Rv3523, (MTCY03C7.33c), len: 394 aa. Probable ltp3, FT lipid carrier protein or keto acyl-CoA thiolase (EC FT 2.3.1.16), similar to several e.g. O30037|AF0202 FT 3-KETOACYL-CoA THIOLASE (ACAB-6) from Archaeoglobus FT fulgidus (380 aa) FASTA scores: opt: 782, E(): 1.7e-40, FT (38.35% identity in 386 aa overlap); Q9Y9A1|APE2384 LONG FT HYPOTHETICAL NON SPECIFIC LIPID-TRANSFER PROTEIN (ACETHYL FT CoA SYNTHETASE) (EC 6.2.1.-) from Aeropyrum pernix (394 FT aa), FASTA scores: opt: 626, E(): 5.9e-31, (35.75% identity FT in 386 aa overlap); BAB59210|TVG0067506 LIPID TRANSFER FT PROTEIN from Thermoplasma volcanium (390 aa), FASTA scores: FT opt: 591, E(): 8.1e-29, (34.35% identity in 384 aa FT overlap); Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC FT LIPID-TRANSFER PROTEIN from Aeropyrum pernix (400 aa) FASTA FT scores: opt: 588, E(): 1.3e-28, (31.6% identity in 408 aa FT overlap); O30104|AF0133 3-KETOACYL-COA THIOLASE (ACAB-3) FT from Archaeoglobus fulgidus (411 aa) FASTA scores: opt: FT 583, E(): 2.6e-28, (39.8% identity in 412 aa overlap); FT O29811|AF0438 3-KETOACYL-CoA THIOLASE (ACAB-8) from FT Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 574, FT E(): 8.8e-28, (30.95% identity in 388 aa overlap); etc." FT /db_xref="GOA:P71878" FT /db_xref="InterPro:IPR002155" FT /db_xref="InterPro:IPR016038" FT /db_xref="InterPro:IPR016039" FT /db_xref="UniProtKB/TrEMBL:P71878" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05053.1" FT /translation="MAGKLAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADSGSTFD FT DIDAVVVGKAPDFFEGVMMPELFMADAMGATGKPLIRVHTAGSVGGSTGVVAASLVQSG FT KYRRVLALAWEKQSESNAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPAHIGA FT MVAVKDRLNGSRNPLAHLQQPDITLEKVMASQMLWDPIRFDETCPSSDGACAVVVGDEE FT IADARLAQGHPVAWIHGTALRTEPLAFAGRDQVNPQAGRDAAAALWKAAGITSPIDEID FT AAEIYVPFSWFEPMWLENLGFAREGEGWKLTEAGETAIGGRLPVNPSGGVLSANPIGAS FT GLIRFAEAAIQVMGKAEARQVPGARKALGHAYGGGSQYFSMWVVGCEKPKQAAA" FT CDS 143579..144610 FT /transl_table=11 FT /locus_tag="Rv3524" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv3524, (MTCY03C7.32c), len: 343 aa. Probable FT conserved membrane protein, showing some similarity to FT C-terminal part of putative Mycobacterium tuberculosis FT proteins FT O05871|P95308|PKND_MYCTU|Rv0931c|MT0958|MTCY08C9.08 FT serine-threonine protein kinase PknD (EC 2.7.1.-) (664 aa) FT FASTA scores: opt: 727, E(): 8.3e-36, (45.3% identity in FT 298 aa overlap); O53893|Rv0980c|MTV044.08c PGRS-FAMILY FT PROTEIN (457 aa), FASTA scores: opt: 208, E(): 4.4e-05, FT (33.75% identity in 166 aa overlap); and FT O53891|Rv0978c|MTV044.06c PGRS-FAMILY PROTEIN (331 aa) FT FASTA scores: opt: 153, E(): 0.062, (30.75% identity in 117 FT aa overlap). Contains PS00237 G-protein coupled receptors FT signature." FT /db_xref="InterPro:IPR001258" FT /db_xref="InterPro:IPR011042" FT /db_xref="InterPro:IPR013017" FT /db_xref="UniProtKB/TrEMBL:O86333" FT /protein_id="CAB05064.1" FT /translation="MVKFTPDSQTSVLRAGKCSGTLSPSRSRLQRGSWPVDSERRRYGW FT PRNRRTLAITGAAVVVVVTLAAIGYLIFEPKISGSSTSRQAASPTTPSPPSQVVVPIDL FT WNPDGVTVDLADAVYVADSGHKRLLKLPAGSNTPTTLPFTDTIGPGGVAVNSNRDVYVI FT DEDSHHVLKLAAGIEPPVELPFGSLGDAHGLAVDRSDSVYVVDYDNAKVLKLPPGADTP FT TELPFVGLDHPYDVAVDGAGTVYVTDSGHNRVVALTAGSATPVHLPFADLSFPAGVTVD FT RDDSVYVADLNNNRVLKLAAGSNAQSQLPFTGLFSPTDVAVDNDGAVYVIDFYNRMLKL FT PTA" FT misc_feature 144134..144184 FT /note="PS00237 G-protein coupled receptors signature." FT CDS complement(144624..145148) FT /transl_table=11 FT /locus_tag="Rv3525c" FT /product="POSSIBLE SIDEROPHORE-BINDING PROTEIN" FT /function="UNKNOWN" FT /note="Rv3525c, (MTCY3C7.31), len: 174 aa. Possible FT siderophore-binding protein, similar to ferripyochelin FT binding proteins (and related) e.g. Q9RSN5|DR2089 FT FERRIPYOCHELIN-BINDING PROTEIN from Deinococcus radiodurans FT (240 aa), FASTA scores: opt: 472, E(): 3.3e-21, (46.9% FT identity in 162 aa overlap); O59257|PH1591 LONG FT HYPOTHETICAL FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus FT horikoshii (173 aa), FASTA scores: opt: 431, E(): 6.7e-19, FT (40.0% identity in 170 aa overlap); Q9V158|FBP|PAB0393 FT FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus abyssi (173 FT aa), FASTA scores: opt: 429, E(): 8.9e-19, (39.4% identity FT in 170 aa overlap); BAB47820|MLR0180 FERRIPYOCHELIN BINDING FT PROTEIN-LIKE from Rhizobium loti (Mesorhizobium loti) (175 FT aa), FASTA scores: opt: 415, E(): 6.1e-18, (42.55% identity FT in 141 aa overlap); etc." FT /db_xref="GOA:P71876" FT /db_xref="HSSP:1THJ" FT /db_xref="InterPro:IPR001451" FT /db_xref="InterPro:IPR011004" FT /db_xref="UniProtKB/TrEMBL:P71876" FT /protein_id="CAB05052.1" FT /translation="MPLFSFEGRSPRIDPTAFVAPTATLIGDVTIEAGASVWFNAVLRG FT DYAPVVVREGANVQDGAVLHAPPGIPVDIGPGATVAHLCVIHGVHVGSEALIANHATVL FT DGAVIGARCMIAAGALVVAGTQIPAGMLVTGAPAKVKGPIEGTGAEMWVNVNPQAYRDL FT AARHLAGLEPM" FT CDS 145263..146423 FT /transl_table=11 FT /locus_tag="Rv3526" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3526, (MTCY03C7.30c), len: 386 aa. Hypothetical FT oxidoreductase (EC 1.-.-.-), highly similar, except in FT C-terminus (also longer 69 aa), to O69348|ORF12 PROTEIN FT (function unknown) from Rhodococcus erythropolis (316 aa) FT FASTA scores: opt: 1137, E(): 6.9e-65, (59.6% identity in FT 250 aa overlap). Also some similarity with several FT aminopyrrolnitrin oxidases (PRND proteins, involved in the FT pathway for pyrrolnitrin biosynthesis, a secondary FT metabolite derived from tryptophan which has strong FT anti-fungal activity) e.g. Q9RPG0|PRND from Myxococcus FT fulvus (379 aa), FASTA scores: opt: 322, E(): 4.4e-13, FT (25.85% identity in 352 aa overlap); Q9RPG4|PRND from FT Burkholderia cepacia (Pseudomonas cepacia) (373 aa) FASTA FT scores: opt: 306, E(): 4.5e-12, (25.2% identity in 373 aa FT overlap); P95483|PRND from Pseudomonas fluorescens (363 FT aa), FASTA scores: opt: 305, E(): 5.1e-12, (25.0% identity FT in 372 aa overlap); etc. And also some similarity to other FT putative enzymes like dioxygenases, oxidases, vanillate FT O-demethyl oxygenase, etc." FT /db_xref="GOA:P71875" FT /db_xref="InterPro:IPR017941" FT /db_xref="PDB:2ZYL" FT /db_xref="UniProtKB/TrEMBL:P71875" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05051.1" FT /translation="MSTDTSGVGVREIDAGALPTRYARGWHCLGVAKDYLEGKPHGVEA FT FGTKLVVFADSHGDLKVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRWGGDGRCKLVPY FT ARRTPRMARTRSWTTDVRSGLLFVWHDHEGNPPDPAVRIPEIPEAASDEWTDWRWNRIL FT IEGSNCRDIIDNVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDDLGTSYG FT EAHLDSEASYFGPSFMINWLHNRYGNYKSESILINCHYPVTQNSFVLQWGVIVEKPKGM FT SEEMTDKLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYEQFYVDV FT ADIKPEMVERFEIEVDTKRANEFWNAEVEKNLKSREVSDDVPAEQH" FT CDS 146429..146878 FT /transl_table=11 FT /locus_tag="Rv3527" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3527, (MTCY03C7.29c), len: 149 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P71874" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05050.1" FT /translation="MPDDQPAVPDVDRLARSMLLLHGDHHDHNDSPEQHRTCGSWSKSR FT DFADDPQRAAAVREASRAERDRYLTSGLQPVDCRFCHVTVTVKRLGPGHTAVQWNTEAS FT RRCAYFTELRARGGDSARTRSCPRLTDSIEHAVAEGYLEHHDPNR" FT CDS complement(147303..148016) FT /transl_table=11 FT /locus_tag="Rv3528c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3528c, (MTCY03C7.28), len: 237 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P71873" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05049.1" FT /translation="MMLDRLRQGGYWLVRGKINLIDRAFTSCRIESFADLGAVWGVEGA FT YTFRALDKYPVKEAVLVDGRITPTVAARANSYPQLRVIEGNFGDQEIADKVGNVDALFL FT FDVLLHQVSPDWDTILDMYAKNVRCLLIYNQQWIGSTTTVRLLDLGEKHYFRNVPHSKL FT NKAYRDLFQKLDKKHPDHDKPWRDIPDIWQWGITDADLESKASELGFKLLYKEDCRGFG FT WLPNIQNRAFLFARQ" FT CDS complement(148708..149862) FT /transl_table=11 FT /locus_tag="Rv3529c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3529c, (MTCY03C7.27), len: 384 aa. Conserved FT hypothetical protein, showing some similarity to FT Q50695|YM67_MYCTU|Rv2267c|MT2329|MTCY339.43 HYPOTHETICAL FT 46.1 KDA PROTEIN from Mycobacterium tuberculosis (388 aa) FT FASTA scores: opt: 261, E(): 1.6e-09, (27.25% identity in FT 253 aa overlap)." FT /db_xref="PDB:2ZQ5" FT /db_xref="UniProtKB/TrEMBL:P71872" FT /protein_id="CAB05048.1" FT /translation="MTRRPDRKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLD FT AYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGT FT TALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDAQFTQHHAENPGYTGL FT HFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLN FT DAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFV FT GAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLS FT DEARQAMTTVHAESQSGARAPKHSYSLADYGLTVEMVKERFAGL" FT CDS complement(149862..150644) FT /transl_table=11 FT /locus_tag="Rv3530c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3530c, (MTCY03C7.26), len: 260 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to various FT oxidoreductases and hypothetical proteins e.g. FT BAB53258|Q987E5|MLL7083 PROBABLE OXIDOREDUCTASE from FT Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: FT opt: 405, E(): 5.3e-18, (33.45% identity in 263 aa FT overlap); Q9VNF3|CG12171 HYPOTHETICAL PROTEIN from FT Drosophila melanogaster (Fruit fly) (257 aa), FASTA scores: FT opt: 404, E(): 6.1e-18, (32.8% identity in 256 aa overlap); FT Q9A3X5|CC3076 OXIDOREDUCTASE (SHORT-CHAIN FT DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus FT (254 aa), FASTA scores: opt: 400, E(): 1.1e-17, (31.0% FT identity in 255 aa overlap); BAB50080|MLR3115 DEHYDROGENASE FT from Rhizobium loti (Mesorhizobium loti) (259 aa), FASTA FT scores: opt: 393, E(): 3e-17, (31.9% identity in 254 aa FT overlap); Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE FT 3-KETO-ACYL-REDUCTASE from Streptomyces antibioticus (273 FT aa), FASTA scores: opt: 388, E(): 6.3e-17, (31.6% identity FT in 250 aa overlap); etc." FT /db_xref="GOA:P71871" FT /db_xref="HSSP:1AHI" FT /db_xref="HSSP:1E7W" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P71871" FT /protein_id="CAB05047.1" FT /translation="MTGMLKRKVIVVSGVGPGLGTTLAHRCARDGADLVLAARSAERLD FT DVAKQIIDTGRRAVAVRTDITDDDDVSNLVQATLAAYGKADVLINNAFRVPSMKPLAGT FT TFEHIRDAIELSALGTLRLIQAFTPALAQSHGAIVNVNSMVIRHSQPKYGTYKMAKSVL FT LAMSHSLATELGEQGIRVNSVAPGYIWGDTLKSYFDHQAGKYGTTVDQIYQATAANSDL FT KRLPTEDEVASAILFLASDLASGITGQTLDVNCGEYHT" FT CDS complement(150641..151768) FT /transl_table=11 FT /locus_tag="Rv3531c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3531c, (MTCY03C7.25), len: 375 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P71870" FT /protein_id="CAB05046.1" FT /translation="MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAGCIAGCMH FT LAFDYERDHPFLQSGTGPFTKMGLDNPDTLYFGTRLQANRDYVVSGRRGTTTDLSFQLL FT GGEYTDYNVPASQAAFDDRELDIAADGSFEWRLRPSAPGQLVIREVYGDWSQQRGTLAI FT ARLDTVGTAPPPLTRELMEKRYATAGSQLVNRVKTWLQFPQWFYLNIPVNTMVAPRLTP FT GGLATQYSSAGHFELRPGQALVITVPVSDAPYLGFQLGSMWYISLDYINHQTSLNASQA FT QADPDGKVRIVVAEQNPGVTNWVETLGHRRGFLQFRWQRVSRELTEADGPTVELVDFDA FT IPAALPHYQHNKISEDDWRARIALRQRQIATRMLG" FT CDS 152167..153387 FT /transl_table=11 FT /gene="PPE61" FT /locus_tag="Rv3532" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3532, (MTCY03C7.24c), len: 406 aa. Member of the FT Mycobacterium tuberculosis PPE protein family, similar to FT many, e.g. O53956|Rv1807|MTV049.29 (403 aa), FASTA scores: FT opt: 954, E(): 1.1e-43, (44.1% identity in 417 aa overlap)" FT /db_xref="HSSP:2G38" FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q6MWW4" FT /protein_id="CAE55609.1" FT /translation="MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAELQSAAE FT TYRSVIASLTGWQWLGPSSVRMGAAVTPYVEWLTTTAAQARQTATQITAAATGFEQAFA FT MTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALETQYAEMWEQDATAMYDYAATSAAA FT RTLTPFTSPQQDTNSAGLPAQSAEVSRATANAGAADGNWLGNLLEEIGILLLPIAPELT FT PFFLEAGEIVNAIPFPSIVGDEFCLLDGLLAWYATIGSINNINSMGTGIIGAEKNLGIL FT PELGSAAAAAAPPPADIAPAFLAPLTSMAKSLSDGALRGPGEVSAAMRGAGTIGQMSVP FT PAWKAPAVTTVRAFDATPMTTLPGGDAPAAGVPGLPGMPASGAGRAGVVPRYGVRLTVM FT TRPLSGG" FT CDS complement(153529..155277) FT /transl_table=11 FT /gene="PPE62" FT /locus_tag="Rv3533c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3533c, (MTCY03C7.23), len: 582 aa. Member of the FT Mycobacterium tuberculosis PPE protein family, similar to FT many, e.g. O53309|Rv3159c|MTV014.03c (590 aa) FASTA scores: FT opt: 2289, E(): 2.3e-95, (63.5% identity in 600 aa FT overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/Swiss-Prot:Q7D5C5" FT /protein_id="CAE55610.1" FT /translation="MNYAVLPPELNSLRMFTGAGSAPMLAAAVAWDGLAAELGSAASSF FT GSVTSDLASQAWQGPAAAAMAAAAAPYAGWLSAAAARAAGAAAQAKAVASAFEAARAAT FT VHPLLVAANRNAFAQLVMSNWFGLNAPLIAAVEGAYEQMWAADVAAMVGYHSGASAAAE FT QLVPFQQALQQLPNLGIGNIGNANLGGGNTGDLNTGNGNIGNTNLGSGNRGDANLGSGN FT IGNSNVGGGNVGNGNFGSGNGRAGLPGSGNVGNGNLGNSNLGSGNTGNSNVGFGNTGNN FT NVGTGNAGSGNIGAGNTGSSNWGFGNNGIGNIGFGNTGNGNIGFGLTGNNQVGIGGLNS FT GSGNIGLFNSGTNNVGFFNSGNGNLGIGNSSDANVGIGNSGATVGPFVAGHNTGFGNSG FT SLNTGMGNAGGVNTGFGNGGAINLGFGNSGQLNAGSFNAGSINTGNFNSGQGNTGDFNA FT GVRNTGWSNSGLTNTGAFNAGSLNTGFGAVGTGSGPNSGFGNAGTNNSGFFNTGVGSSG FT FQNGGSNNSGLQNAVGTVIAAGFGNTGAQTVGIANSGVLNSGFFNSGVHNSGGFNSENQ FT RSGFGN" FT CDS complement(155376..156416) FT /transl_table=11 FT /locus_tag="Rv3534c" FT /product="PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA)" FT /function="SUPPOSED INVOLVEMENT IN ONE, OR SEVERAL, FT CATABOLIC PATHWAYS [CATALYTIC ACTIVITY: FT 4-HYDROXY-2-OXOVALERATE = PYRUVATE + ACETALDEHYDE]." FT /EC_number="4.1.3.-" FT /note="Rv3534c, (MTCY03C7.22), len: 346 aa. Probable FT 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), highly FT similar to others e.g. P51015|BPHI_PSESP from Pseudomonas FT sp. strain LB400 (346 aa), FASTA scores: opt: 1150, E(): FT 2.3e-61, (51.35% identity in 331 aa overlap); Q52040|BPHX3 FT from Pseudomonas pseudoalcaligenes (346 aa), FASTA scores: FT opt: 1147, E(): 3.5e-61, (51.35% identity in 331 aa FT overlap); P51017|NAHM_PSEPU from Pseudomonas putida (346 FT aa), FASTA scores: opt: 1145, E(): 4.7e-61, (50.9% identity FT in 330 aa overlap) (see citation below); FT P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain FT K12 (337 aa), FASTA scores: opt: 1133, E(): 2.4e-60, (52.0% FT identity in 327 aa overlap); O24833|ATDG from Acinetobacter FT sp (340 aa), FASTA scores: opt: 1132, E(): 2.7e-60, (50.45% FT identity in 331 aa overlap); etc. Note that also highly FT similar to Q9ZI56|NAHM 2-OXO-4-HYDROXYPENTANOATE ALDOLASE FT from Pseudomonas stutzeri (Pseudomonas perfectomarina) (346 FT aa) FASTA scores: opt: 1168, E(): 2e-62, (51.05% identity FT in 331 aa overlap) (see citation below)." FT /db_xref="GOA:P71867" FT /db_xref="HSSP:1NVM" FT /db_xref="InterPro:IPR000891" FT /db_xref="InterPro:IPR012425" FT /db_xref="InterPro:IPR013785" FT /db_xref="InterPro:IPR017629" FT /db_xref="UniProtKB/Swiss-Prot:P71867" FT /protein_id="CAB05044.1" FT /translation="MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVI FT EVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNG FT GSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQC FT VYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQID FT GSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNAL FT IMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDS FT GAAVTH" FT CDS complement(156413..157324) FT /transl_table=11 FT /locus_tag="Rv3535c" FT /product="PROBABLE ACETALDEHYDE DEHYDROGENASE (ACETALDEHYDE FT DEHYDROGENASE [ACETYLATING])" FT /function="SUPPOSED INVOLVEMENT IN ONE, OR SEVERAL, FT CATABOLIC PATHWAY [CATALYTIC ACTIVITY: ACETALDEHYDE + CoA + FT NAD(+) = ACETYL-CoA + NADH]." FT /EC_number="1.2.1.10" FT /note="Rv3535c, (MTCY03C7.21), len: 303 aa. Probable FT acetaldehyde dehydrogenase (EC 1.2.1.10), highly similar to FT many e.g. BAB62056|TDNI from Pseudomonas putida (302 aa), FT FASTA scores: opt: 1159, E(): 1.5e-62, (60.45% identity in FT 301 aa overlap); Q9ZI57|NAHO from Pseudomonas stutzeri FT (Pseudomonas perfectomarina) (307 aa) FASTA scores: opt: FT 1151, E(): 4.6e-62, (59.55% identity in 299 aa overlap); FT Q9F9I4|CDOI from Comamonas sp. JS765 (302 aa) FASTA scores: FT opt: 1136, E(): 3.6e-61, (60.15% identity in 301 aa FT overlap); Q51962|NAHO from Pseudomonas putida (307 aa), FT FASTA scores: opt: 1133, E(): 5.6e-61, (58.55% identity in FT 299 aa overlap) (see citation below); FT P77580|MHPF_ECOLI|MHPF|MHPE|B0351 from Escherichia coli FT strain K12 (316 aa), FASTA scores: opt: 1040, E(): 2.2e-55, FT (56.85% identity in 306 aa overlap); etc." FT /db_xref="GOA:P71866" FT /db_xref="InterPro:IPR000534" FT /db_xref="InterPro:IPR003361" FT /db_xref="InterPro:IPR015426" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P71866" FT /protein_id="CAB05043.1" FT /translation="MPSKAKVAIVGSGNISTDLLYKLLRSEWLEPRWMVGIDPESDGLA FT RAAKLGLETTHEGVDWLLAQPDKPDLVFEATSAYVHRDAAPKYAEAGIRAIDLTPAAVG FT PAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVSRIVEVPYAEIVASVASVSAGPGT FT RANIDEFTKTTARGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPTDADREAIAAS FT IHDVVKEVQTYVPGYRLLNEPQFDEPSINSGGQALVTTFVEVEGAGDYLPPYAGNLDIM FT TAAATKVGEEIAKETLVVGGAR" FT CDS complement(157335..158120) FT /transl_table=11 FT /locus_tag="Rv3536c" FT /product="PROBABLE HYDRATASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="4.2.1.-" FT /note="Rv3536c, (MTCY03C7.20), len: 261 aa. Probable FT hydratase, 2-oxo-hepta-3-ene-1,7-dioate hydratase (EC FT 4.2.1.-) or 2-keto-4-pentenoate hydratase (EC 4.2.1.-). FT Indeed, highly similar to many 2-oxo-hepta-3-ene-1,7-dioate FT hydratases e.g. Q9CKS2|HPAH|PM1534 from Pasteurella FT multocida (267 aa) FASTA scores: opt: 743, E(): 1.5e-39, FT (45.5% identity in 266 aa overlap) Q9RZ31|DRA0122 from FT Deinococcus radiodurans (268 aa), FASTA scores: opt: 709, FT E(): 2e-37, (45.5% identity in 266 aa overlap); FT Q9HWQ4|HPCG|PA4127 from Pseudomonas aeruginosa (267 aa), FT FASTA scores: opt: 703, E(): 4.8e-37, (45.1% identity in FT 266 aa overlap); Q46982|HPAH|HPCG from Escherichia colis FT strain ATCC 11105 (267 aa), FASTA scores: opt: 679, E(): FT 1.6e-35, (41.35% identity in 266 aa overlap); etc. But also FT highly similar to many 2-keto-4-pentenoate hydratases FT (2-hydroxypentadienoic acidhydratases) e.g. Q9LAF7|PHED FT from Bacillus thermoglucosidasius (258 aa), FASTA scores: FT opt: 698, E(): 9.7e-37, (42.45% identity in 252 aa FT overlap); Q52442|BPHH from Pseudomonas sp (260 aa) FASTA FT scores: opt: 675, E(): 2.7e-35, (41.4% identity in 251 aa FT overlap); P77608|MHPD_ECOLI|B0350 from Escherichia coli FT strain K12 (269 aa), FASTA scores: opt: 674, E(): 3.2e-35, FT (42.75% identity in 255 aa overlap); Q52038|BPHX1 from FT Pseudomonas pseudoalcaligenes (260 aa), FASTA scores: opt: FT 663, E(): 1.5e-34, (40.6% identity in 251 aa overlap); FT etc." FT /db_xref="GOA:P71865" FT /db_xref="InterPro:IPR002529" FT /db_xref="InterPro:IPR011234" FT /db_xref="UniProtKB/TrEMBL:P71865" FT /protein_id="CAB05042.1" FT /translation="MLRDATRDELAADLAQAERSRDPIGQLTAAHPEIDVVDAYEIQLI FT NIRQRVAEGARVVGHKVGLSSPIMQQMMGVDEPDYGHLLDDMQVFEDTPVQASRYLSPR FT VEVEVGFILAADLPGAGCTEDDVLAATEALVPAIELIDTRIKDWQIKICDTIADNASAA FT GFVLGAARVPPADLDVRAIDAKLTRNGEVVAEGRSDAVLGNPATAVAWLAGKVESFGVR FT LRKGDIVLPGSCTFAVEARAGDEFVADFTGLGLVRLSFE" FT CDS 158193..159884 FT /transl_table=11 FT /locus_tag="Rv3537" FT /product="PROBABLE DEHYDROGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3537, (MTCY03C7.19c), len: 563 aa. Probable FT dehydrogenase (EC 1.-.-.-), similar to many dehydrogenases FT or hypothetical proteins e.g. Q9I1M6|PA2243 HYPOTHETICAL FT PROTEIN from Pseudomonas aeruginosa (577 aa), FASTA scores: FT opt: 984, E(): 1.2e-48, (34.75% identity in 573 aa FT overlap); Q06401|3O1D_COMTE 3-OXOSTEROID 1-DEHYDROGENASE FT from Comamonas testosteroni (Pseudomonas testosteroni) (573 FT aa), FASTA scores: opt: 955, E(): 5.5e-47, (33.05% identity FT in 590 aa overlap); Q9RA02|KSTD1 3-KETOSTEROID FT DEHYDROGENASE from Rhodococcus erythropolis (510 aa), FASTA FT scores: opt: 631, E(): 1.4e-28, (39.15% identity in 557 aa FT overlap); P77815|KSDD 3-KETOSTEROID-1-DEHYDROGENASE from FT Nocardioides simplex (Arthrobacter simplex) (515 aa), FASTA FT scores: opt: 469, E(): 2.4e-19, (35.45% identity in 564 aa FT overlap); etc." FT /db_xref="GOA:P71864" FT /db_xref="HSSP:1D4D" FT /db_xref="InterPro:IPR003953" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:P71864" FT /protein_id="CAB05041.1" FT /translation="MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTA FT RSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLK FT HTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLNVVV FT MQQDYVRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVP FT VELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKY FT QRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSP FT GSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAG FT LQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRG FT ESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSII FT DGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR" FT CDS 159886..160746 FT /transl_table=11 FT /locus_tag="Rv3538" FT /standard_name="ufaA2" FT /product="PROBABLE DEHYDROGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3538, (MTCY03C7.18c), len: 286 aa. Probable FT dehydrogenase (EC 1.-.-.-), similar to Q9L009|SCC30.12c FT PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 FT aa), FASTA scores: opt: 842, E(): 3.6e-44, (48.4% identity FT in 285 aa overlap); and similar to C-terminal part of other FT (principally ESTRADIOL 17 FT BETA-DEHYDROGENASES/17-BETA-HYDROXYSTEROID DEHYDROGENASES) FT e.g. P70540 PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE II (SDR FT FAMILY) from Rattus norvegicus (Rat) (735 aa) FASTA scores: FT opt: 622, E(): 1.9e-30, (37.45% identity in 283 aa FT overlap); or P70523|MPF-2 MULTIFUNCTIONAL PROTEIN 2 (SDR FT FAMILY) (beta-oxidation protein displaying 2-enoyl-CoA FT hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity) FT from Rattus norvegicus (Rat) (734 aa), FASTA scores: opt: FT 616, E(): 4.3e-30, (37.1% identity in 283 aa overlap); FT P51659|DHB4_HUMAN|HSD17B4|EDH17B4 ESTRADIOL 17 FT BETA-DEHYDROGENASE (EC 1.1.1.62) from Homo sapiens (Human) FT (736 aa), FASTA scores: opt: 614, E(): 5.7e-30, (35.9% FT identity in 284 aa overlap); FT P97852|DHB4_RAT|HSD17B4|EDH17B4 ESTRADIOL 17 FT BETA-DEHYDROGENASE from Rattus norvegicus (Rat) (735 aa) FT FASTA scores: opt: 613, E(): 6.6e-30, (37.1% identity in FT 283 aa overlap); Q9DBM3|HSD17B4 ESTRADIOL 17 FT BETA-DEHYDROGENASE from Mus musculus (Mouse) (735 aa) FASTA FT scores: opt: 611, E(): 8.7e-30, (36.5% identity in 285 aa FT overlap); etc. Also similar to Q11198|Rv3389c|MTV004.47c FT HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium FT tuberculosis (290 aa), FASTA scores: opt: 609, E(): FT 5.3e-30, (39.65% identity in 285 aa overlap). Note that FT previously known as ufaA2." FT /db_xref="GOA:Q6MWW2" FT /db_xref="InterPro:IPR002539" FT /db_xref="UniProtKB/TrEMBL:Q6MWW2" FT /protein_id="CAE55611.1" FT /translation="MPIDLDVALGAQLPPVEFSWTSTDVQLYQLGLGAGSDPMNPRELS FT YLADDTPQVLPTFGNVAATFHLTTPPTVQFPGIDIELSKVLHASERVEVPAPLPPSGSA FT RAVTRFTDIWDKGKAAVICSETTATTPDGLLLWTQKRSIYARGEGGFGGKRGPSGSDVA FT PERAPDLQVAMPILPQQALLYRLCGDRNPLHSDPEFAAAAGFPRPILHGLCTYGMTCKA FT IVDALLDSDATAVAGYGARFAGVAYPGETLTVNVWKDGRRLVASVVAPTRDNAVVLSGV FT ELVPA" FT CDS 160883..162322 FT /transl_table=11 FT /gene="PPE63" FT /locus_tag="Rv3539" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3539, (MTCY03C7.17c), len: 479 aa. Member of the FT Mycobacterium tuberculosis PPE protein family, similar to FT many e.g. O53949|Rv1800|MTV049.22 (655 aa), FASTA scores: FT opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa FT overlap); etc." FT /db_xref="HSSP:2G38" FT /db_xref="InterPro:IPR000030" FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/Swiss-Prot:Q7D5B9" FT /protein_id="CAE55612.1" FT /translation="MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAAS FT FESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMALAYEAAFAA FT TVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVASAVG FT ARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPFIGRL FT LAARYAELNTAIGTNWFPGTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEIL FT AATASGQPVTVAGLSMGSMVIDRELAYLAIDPNAPPSSALTFVELAGPERGLAQTYLPV FT GTTIPIAGYTVGNAPESQYNTSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTA FT YAAPQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVD FT AGYSQYAPTAGPYFSHGNLVW" FT CDS complement(162323..163483) FT /transl_table=11 FT /gene="ltp2" FT /locus_tag="Rv3540c" FT /product="PROBABLE LIPID TRANSFER PROTEIN OR KETO ACYL-COA FT THIOLASE LTP2" FT /function="UNKNOWN, SUPPOSED INVOLVEMENT IN LIPID FT METABOLISM." FT /EC_number="2.3.1.16" FT /note="Rv3540c, (MTCY03C7.16), len: 386 aa. Probable ltp2, FT lipid-transfer protein or keto acyl-CoA thiolase (EC FT 2.3.1.16), similar to several e.g. Q9X4X2|DITF DITF PROTEIN FT (hypothetical protein, similar to non-specific FT lipid-transfer protein and 3-ketoacyl-CoA thiolase) from FT Pseudomonas abietaniphila (397 aa), FASTA scores: opt: 665, FT E(): 5.3e-34, (33.4% identity in 392 aa overlap); FT O30255|AF2416 3-KETOACYL-CoA THIOLASE (ACAB-12) from FT Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 496, FT E(): 1.6e-23, (30.35% identity in 389 aa overlap); FT O28978|AF1291 3-KETOACYL-CoA THIOLASE (ACAB-11) from FT Archaeoglobus fulgidus (392 aa), FASTA scores: opt: 494, FT E(): 2.2e-23, (30.6% identity in 379 aa overlap); FT O26884|MTH793 LIPID-TRANSFER PROTEIN (STEROL OR FT NONSPECIFIC) from Methanobacterium thermoautotrophicum (383 FT aa), FASTA scores: opt: 487, E(): 5.9e-23, (30.4% identity FT in 388 aa overlap); etc." FT /db_xref="GOA:P71861" FT /db_xref="InterPro:IPR002155" FT /db_xref="InterPro:IPR016039" FT /db_xref="UniProtKB/TrEMBL:P71861" FT /protein_id="CAB05038.1" FT /translation="MLSGQAAIVGIGATDFSKNSGRSELRLAAEAVLDALADAGLSPTD FT VDGLTTFTMDTNTEIAVARAAGIGELTFFSKIHYGGGAACATVQHAAMAVATGVADVVV FT AYRAFNERSGMRFGQVQTRLTENADSTGVDNSFSYPHGLSTPAAQVAMIARRYMHLSGA FT TSRDFGAVSVADRKHAANNPKAYFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGAVAI FT VVTSAARARDLKQRPVVIEAAAQGCSPDQYTMVSYYRPELDGLPEMGLVGRQLWAQSGL FT TPADVQTAVLYDHFTPFTLIQLEELGFCGKGEAKDFIADGAIEVGGRLPINTHGGQLGE FT AYIHGMNGIAEGVRQLRGTSVNPVAGVEHVLVTAGTGVPTSGLILG" FT CDS complement(163483..163872) FT /transl_table=11 FT /locus_tag="Rv3541c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3541c, (MTCY03C7.15), len: 129 aa. Hypothetical FT protein, showing some similarity to Q9CBJ7|ML1909 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (142 aa) FT FASTA scores: opt: 110, E(): 1.2, (27.95% identity in 118 FT aa overlap); and other (see also BLASTP results) e.g. FT Q9L0M3|SCD82.08 HYPOTHETICAL 15.2 KDA PROTEIN from FT Streptomyces coelicolor (142 aa), FASTA scores: opt: 127, FT E(): 0.086, (27.65% identity in 123 aa overlap). Contains FT PS00075 Dihydrofolate reductase signature." FT /db_xref="UniProtKB/TrEMBL:P71860" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05037.1" FT /translation="MTVVGAVLPELKLYGDPTFIVSTALATRDFQDVHHDRDKAVAQGS FT KDIFVNILTDTGLVQRYVTDWAGPSALIKSIGLRLGVPWYAYDTVTFSGEVTAVNDGLI FT TVKVVGRNTLGDHVTATVELSMRDS" FT misc_feature complement(163621..163647) FT /note="PS00075 Dihydrofolate reductase signature." FT CDS complement(163869..164804) FT /transl_table=11 FT /locus_tag="Rv3542c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3542c, (MTCY03C7.14), len: 311 aa. Hypothetical FT protein, showing some similarity to other e.g. FT Q58947|MJ1552 from Methanococcus jannaschii (141 aa) FASTA FT scores: opt: 177, E(): 0.00065, (46.65% identity in 60 aa FT overlap); BAB59276|TVG0142586 from Thermoplasma volcanium FT (135 aa), FASTA scores: opt: 175, E(): 0.00083, (35.65% FT identity in 87 aa overlap); Q9HI85|TA1457 from Thermoplasma FT acidophilum (135 aa), FASTA scores: opt: 162, E(): 0.0052, FT (31.8% identity in 107 aa overlap); etc." FT /db_xref="InterPro:IPR002878" FT /db_xref="UniProtKB/TrEMBL:P71859" FT /protein_id="CAB05036.1" FT /translation="MTGVSDIQEAVAQIKAAGPSKPRLARDPVNQPMINNWVEAIGDRN FT PIYVDDAAARAAGHPGIVAPPAMIQVWTMMGLGGVRPKDDPLGPIIKLFDDAGYIGVVA FT TNCEQTYHRYLLPGEQVSISAELGDVVGPKQTALGEGWFINQHIVWQVGDEDVAEMNWR FT ILKFKPAGSPSSVPDDLDPDAMMRPSSSRDTAFFWDGVKAHELRIQRLADGSLRHPPVP FT AVWQDKSVPINYVVSSGRGTVFSFVVHHAPKVPGRTVPFVIALVELEEGVRMLGELRGA FT DPARVAIGMPVRATYIDFPDWSLYAWEPDE" FT CDS complement(164801..165964) FT /transl_table=11 FT /gene="fadE29" FT /locus_tag="Rv3543c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE29" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv3543c, (MTCY03C7.13), len: 387 aa. Probable FT fadE29, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. Q9A8P3|CC1310 from Caulobacter crescentus (404 FT aa), FASTA scores: opt: 624, E(): 9.4e-32, (32.75% identity FT in 400 aa overlap); Q9I4V2|PA1022 from Pseudomonas FT aeruginosa (381 aa), FASTA scores: opt: 550, E(): 3.9e-27, FT (33.7% identity in 350 aa overlap); O28976|AF1293 from FT Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 529, FT E(): 8.1e-26, (30.0% identity in 393 aa overlap); etc. Also FT similar to other from Mycobacterium tuberculosis e.g. FT O53549|FADE26|Rv3504|MTV023.11 (400 aa), FASTA scores: opt: FT 1031, E(): 2.8e-57, (46.0% identity in 402 aa overlap). FT COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY." FT /db_xref="GOA:P71858" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006091" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:P71858" FT /protein_id="CAB05063.1" FT /translation="MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHGPAYRAVI FT RRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLPAVTLQTVGPTLQAHGSE FT LQKKKFLPAILAGEAHFAIGYTEPEAGTDLASLRTTAVRDGDHYIVNGQKVFTTGAHDA FT DYIWLACRTDPNAAKHKGISILIVDTKDPGYSWTPIILADGAHHTNATYYNDVRVPVDM FT LVGKENDGWRLITTQLNNERVMLGPAGRFASIYDRVHAWASVPGGNGVTPIDHDDVKRA FT LGEIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERVQRAGRLAEEIVGKYGNPA FT EPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMIAASGLKVPRVPR" FT CDS complement(165949..166968) FT /transl_table=11 FT /gene="fadE28" FT /locus_tag="Rv3544c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE28" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv3544c, (MTCY03C7.12), len: 339 aa. Probable FT fadE28, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. Q9RJX3|SCF37.28c from Streptomyces coelicolor FT (362 aa), FASTA scores: opt: 334, E(): 5.1e-13, (27.65% FT identity in 329 aa overlap); Q9A5G8|CC2479 from Caulobacter FT crescentus (344 aa), FASTA scores: opt: 278, E(): 1.2e-09, FT (26.95% identity in 319 aa overlap); O29813|AF0436 from FT Archaeoglobus fulgidus (382 aa) FASTA scores: opt: 205, FT E(): 3.5e-05, (24.75% identity in 384 aa overlap); etc. FT Also similar to other from Mycobacterium tuberculosis e.g. FT O53550|FADE27|Rv3505|MTV023.12 (373 aa) FASTA scores: opt: FT 497, E(): 7e-23, (30.3% identity in 343 aa overlap); and to FT P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE FT ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (389 aa) FT FASTA scores: opt: 165, E(): 0.0012, (25.2% identity in 345 FT aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:P71857" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:P71857" FT /protein_id="CAB05062.1" FT /translation="MDFDPTAEQQAVADVVTSVLERDISWEALVCGGVTALPVPERLGG FT DGVGLFEVGALLTEVGRHGAVTPALATLGLGVVPLLELASAEQQDRFLAGVAKGGVLTA FT ALNEPGAALPDRPATSFVGGRLSGTKVGVGYAEQADWMLVTADNAVVVVSPTADGVRMV FT RTPTSNGSDEYVMTMDGVAVADCDILADVAAHRVNQLALAVMGAYADGLVAGALRLTAD FT YVANRKQFGKPLSTFQTVAAQLAEVYIASRTIDLVAKSVIWRLAEDLDAGDDLGVLGYW FT VTSQAPPAMQICHHLHGGMGMDVTYPMHRYYSTIKDLTRLLGGPSHRLELLGARCSLT" FT CDS complement(166968..168269) FT /transl_table=11 FT /gene="cyp125" FT /locus_tag="Rv3545c" FT /product="PROBABLE CYTOCHROME P450 125 CYP125" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv3545c, (MT3649, MTCY03C7.11), len: 433 aa. FT Probable cyp125, cytochrome P-450 (EC 1.14.-.-), similar to FT others e.g. Q59723|LINC|CYP111 from Pseudomonas incognita FT (406 aa), FASTA scores: opt: 831, E(): 8e-45, (34.75% FT identity in 406 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from FT Streptomyces coelicolor (411 aa), FASTA scores: opt: 694, FT E(): 3.3e-36, (32.35% identity in 417 aa overlap); FT Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FT FASTA scores: opt: 664, E(): 2.5e-34, (34.15% identity in FT 413 aa overlap); O08469|CPXY_BACSU|CYPA|CYP107J1 from FT Bacillus subtilis (410 aa), FASTA scores: opt: 579, E(): FT 5.6e-29, (30.05% identity in 366 aa overlap); etc. Also FT similar to other from Mycobacterium tuberculosis e.g. FT Q50696|CYP124|Rv2266|MT2328|MTCY339.44c (428 aa) FASTA FT scores: opt: 1040, E(): 6.1e-58, (40.75% identity in 432 aa FT overlap). BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P63709" FT /db_xref="InterPro:IPR001128" FT /db_xref="InterPro:IPR002397" FT /db_xref="UniProtKB/Swiss-Prot:P63709" FT /protein_id="CAB05061.1" FT /translation="MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAE FT LRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKNDI FT AREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGS FT GDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSAELIG FT YAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGM FT MAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMF FT YRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMP FT DLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH" FT CDS 168381..169556 FT /transl_table=11 FT /gene="fadA5" FT /locus_tag="Rv3546" FT /product="PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA5 FT (ACETOACETYL-CoA THIOLASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION FT [CATALYTIC ACTIVITY: 2 ACETYL-CoA = CoA + FT ACETOACETYL-COA]." FT /EC_number="2.3.1.9" FT /note="Rv3546, (MTCY03C7.10c), len: 391 aa. Probable fadA5, FT acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many FT e.g. Q9AA29|CC0779 from Caulobacter crescentus (390 aa), FT FASTA scores: opt: 999, E(): 7.1e-54, (43.5% identity in FT 400 aa overlap); Q9K783|BH3487 from Bacillus halodurans FT (393 aa), FASTA scores: opt: 843, E(): 2.6e-44, (37.45% FT identity in 398 aa overlap); Q9RRK9|DR2480 from Deinococcus FT radiodurans (399 aa), FASTA scores: opt: 826, E(): 2.8e-43, FT (38.15% identity in 396 aa overlap); P45369|THIL_CHRVI|PHBA FT from Chromatium vinosum (394 aa) FASTA scores: opt: 790, FT E(): 4.5e-41, (39.4% identity in 401 aa overlap); etc. FT Contains PS00737 Thiolases signature 2. BELONGS TO THE FT THIOLASE FAMILY." FT /db_xref="GOA:P71855" FT /db_xref="HSSP:1AFW" FT /db_xref="InterPro:IPR002155" FT /db_xref="InterPro:IPR016038" FT /db_xref="InterPro:IPR016039" FT /db_xref="InterPro:IPR020613" FT /db_xref="InterPro:IPR020616" FT /db_xref="InterPro:IPR020617" FT /db_xref="UniProtKB/TrEMBL:P71855" FT /protein_id="CAB05060.1" FT /translation="MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQS FT GLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAGLPEHVGATTVDCQCGSGQQANHLIA FT GLIAAGAIDVGIACGIEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAKRRG FT ITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRE FT TTMAGLGELKPVLEGGIHTAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVG FT AEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFASVVLSWARVHEPDMDRVNVNG FT GAIALGHPVGCTGSRLITTALHELERTDQSLALITMCAGGALSTGTIIERI" FT misc_feature 169389..169439 FT /note="PS00737 Thiolases signature 2." FT CDS 169668..170123 FT /transl_table=11 FT /locus_tag="Rv3547" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3547, (MTCY03C7.09c), len: 151 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. O85698|3SCF60.07 from Streptomyces lividans FT and Streptomyces coelicolor (149 aa), FASTA scores: opt: FT 353, E(): 6.3e-17, (42.55% identity in 134 aa overlap); FT Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa) FASTA FT scores: opt: 290, E(): 2.1e-12, (38.5% identity in 122 aa FT overlap) (similarity in N-terminus for this protein); FT BAB52932|Q988L5|MLL6688 from Rhizobium loti (Mesorhizobium FT loti) (148 aa), FASTA scores: opt: 105, E(): 3, (26.75% FT identity in 86 aa overlap). Also similar to mycobacterial FT hypothetical proteins e.g. Q9ZH81 from Mycobacterium FT paratuberculosis (144 aa), FASTA scores: opt: 366, E(): FT 8.2e-18, (43.9% identity in 123 aa overlap); and FT Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c from FT Mycobacterium tuberculosis (148 aa), FASTA scores: opt: FT 330, E(): 2.2e-15, (39.75% identity in 151 aa overlap); FT etc." FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/TrEMBL:P71854" FT /protein_id="CAB05059.1" FT /translation="MPKSPPRFLNSPLSDFFIKWMSRINTWMYRRNDGEGLGGTFQKIP FT VALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQIKK FT EVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCEP" FT CDS complement(170206..171120) FT /transl_table=11 FT /locus_tag="Rv3548c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; SUPPOSED INVOLVEMENT IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3548c, (MTCY03C7.08), len: 304 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), highly FT similar to various dehydrogenases/reductases (generally FT belonging to the SDR FAMILY) e.g. Q9I4V1|PA1023 from FT Pseudomonas aeruginosa (305 aa), FASTA scores: opt: 446, FT E(): 1.7e-17, (43.75% identity in 256 aa overlap); FT Q9A6K0|CC2093 from Caulobacter crescentus (301 aa) FASTA FT scores: opt: 437, E(): 5.3e-17, (42.8% identity in 257 aa FT overlap); Q9HYH8|PA3427 from Pseudomonas aeruginosa (303 FT aa), FASTA scores: opt: 399, E(): 6.5e-15, (45.5% identity FT in 257 aa overlap); Q9VXJ0|CG3415 from Drosophila FT melanogaster (Fruit fly) (598 aa), FASTA scores: opt: 402, FT E(): 7.5e-15, (40.7% identity in 285 aa overlap); etc. Also FT highly similar to O53547|Rv3502c|MTV023.09c PUTATIVE FT SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from (317 aa) FT FASTA scores: opt: 739, E(): 1.6e-33, (45.15% identity in FT 310 aa overlap); and other proteins from Mycobacterium FT tuberculosis. Contains PS00061 Short-chain alcohol FT dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P71853" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P71853" FT /protein_id="CAB05058.1" FT /translation="MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGS FT PASGGSAAQDVVDEILAAGGQAVADGSDISDWDQAANLIQAAVETYGGVDVLVNNAGIV FT RDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTSSGA FT GLQGSVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEMMAKP FT QEGFDAMAPENVSPLVVWLGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDP FT AELGPVVSDLLAKSRPPVPVYGA" FT misc_feature complement(170554..170640) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature." FT CDS complement(171143..171922) FT /transl_table=11 FT /locus_tag="Rv3549c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; SUPPOSED INVOLVEMENT IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3549c, (MTCY03C7.07), len: 259 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), similar FT to various dehydrogenases/reductases (generally belong to FT the SDR FAMILY) e.g. Q9UKU3 from Homo sapiens (Human) (270 FT aa), FASTA scores: opt: 451, E(): 4.8e-21, (38.05% identity FT in 247 aa overlap); Q9S274|SCI28.09c from Streptomyces FT coelicolor (234 aa), FASTA scores: opt: 439, E(): 2.4e-20, FT (36.8% identity in 231 aa overlap); Q9PFI6|XF0671 from FT Xylella fastidiosa (247 aa), FASTA scores: opt: 437, E(): FT 3.4e-20, (37.7% identity in 252 aa overlap); etc. Also FT highly similar to O33308|FABG5|Rv2766c|MTV002.31c ALCOHOL FT DEHYDROGENASE (SDR FAMILY) from Mycobacterium tuberculosis FT (260 aa), FASTA scores: opt: 504, E(): 2.3e-24, (38.5% FT identity in 244 aa overlap). Contains PS00061 Short-chain FT alcohol dehydrogenase family signature. BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P71852" FT /db_xref="HSSP:1AE1" FT /db_xref="HSSP:1Q7B" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P71852" FT /protein_id="CAB05057.1" FT /translation="MTLAEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVIT FT CARRAVDGQPYEFHRCDIRDEDSVKRLVGEIGERHGRLDMLVNNAGGSPYALAAEATHN FT FHRKIVELNVLAPLLVSQHANVLMQAQPNGGSIVNICSVSGRRPTPGTAAYGAAKAGLE FT NLTTTLAVEWAPKVRVNAVVVGMVETERSELFYGDAESIARVAATVPLGRLARPADIGW FT AAAFLASDAASYISGATLEVHGGGEPPPYLGASSANK" FT misc_feature complement(171413..171499) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature." FT CDS 171977..172720 FT /transl_table=11 FT /gene="echA20" FT /locus_tag="Rv3550" FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA20 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv3550, (MTCY03C7.06c), len: 247 aa. Probable FT echA20, enoyl-CoA hydratase (EC 4.2.1.17), similar to FT others e.g. Q9A7B0|CC1814 from Caulobacter crescentus (275 FT aa), FASTA scores: opt: 488, E(): 3.5e-24, (36.4% identity FT in 239 aa overlap); O84978|PHAA from Pseudomonas putida FT (293 aa), FASTA scores: opt: 383, E(): 2e-17, (33.85% FT identity in 254 aa overlap); BAB48479|Q98LI4|MLL1009 from FT Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: FT opt: 378, E(): 3.8e-17, (21.45% identity in 231 aa FT overlap); etc. COULD BELONG TO THE ENOYL-COA FT HYDRATASE/ISOMERASE FAMILY." FT /db_xref="GOA:P71851" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:P71851" FT /protein_id="CAB05056.1" FT /translation="MPITSTTPEPGIVAVTVDYPPVNAIPSKAWFDLADAVTAAGANSD FT TRAVILRAEGRGFNAGVDIKEMQRTEGFTALIDANRGCFAAFRAVYECAVPVIAAVNGF FT CVGGGIGLVGNSDVIVASEDATFGLPEVERGALGAATHLSRLVPQHLMRRLFFTAATVD FT AATLQHFGSVHEVVSRDQLDEAALRVARDIAAKDTRVIRAAKEALNFIDVQRVNASYRM FT EQGFTFELNLAGVADEHRDAFVKKS" FT CDS 172720..173598 FT /transl_table=11 FT /locus_tag="Rv3551" FT /product="POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT)" FT /function="UNKNOWN. PROBABLE SUBUNIT OF A COA-TRANSFERASE FT COMPOSED OF RV3551|MTCY03C7.05c AND RV3552|MTCY03C7.03c." FT /EC_number="2.8.3.-" FT /note="Rv3551, (MTCY03C7.05c), len: 292 aa. Possible FT CoA-transferase, alpha subunit (EC 2.8.3.-), similar in FT part to other CoA-transferases e.g. Q59111|GCTA_ACIFE|GCTA FT GLUTACONATE COA-TRANSFERASE SUBUNIT A (EC 2.8.3.12) (GCT FT LARGE SUBUNIT) from Acidaminococcus fermentans (319 aa) FT FASTA scores: opt: 247, E(): 6.3e-09, (27.35% identity in FT 307 aa overlap); Q9XD83|PCAI from Streptomyces sp. 2065 FT (251 aa), FASTA scores: opt: 222, E(): 2.3e-07, (27.55% FT identity in 243 aa overlap); BAB50895|MLL4183 from FT Rhizobium loti (Mesorhizobium loti) (285 aa), FASTA scores: FT opt: 206, E(): 2.8e-06, (27.4% identity in 281 aa overlap); FT etc. Also some similarity with FT O06167|SCOA_MYCTU|RVv504c|MT2579|MTCY07A7.10c PROBABLE FT SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE SUBUNIT A FT from Mycobacterium tuberculosis (248 aa), FASTA scores: FT opt: 210, E(): 1.4e-06, (25.5% identity in 247 aa overlap). FT BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT A FT FAMILY. Note that this putative protein may combine with FT the putative protein encoded by the downstream ORF Rv3552 FT to form a CoA-transferase that comprises two subunits." FT /db_xref="GOA:P71850" FT /db_xref="InterPro:IPR004165" FT /db_xref="UniProtKB/Swiss-Prot:P71850" FT /protein_id="CAB05066.1" FT /translation="MPDKRTALDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDVT FT DLTVVTYGGPDLGLLCSAGKVKRVYYGFVSLDSPPFYDPWFAHARTSGAIEAREMDEGM FT LRCGLQAAAQRLPFLPIRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPALRLD FT AAFAHLNLGDSHGNAAYTGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQALLV FT NRMMVDAIVEAPGGAHFTTAAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSGTEADY FT QAAVHNFGASR" FT CDS 173595..174347 FT /transl_table=11 FT /locus_tag="Rv3552" FT /product="POSSIBLE COA-TRANSFERASE (BETA SUBUNIT)" FT /function="UNKNOWN. PROBABLE SUBUNIT OF A COA-TRANSFERASE FT COMPOSED OF RV3551|MTCY03C7.05c AND RV3552|MTCY03C7.03c." FT /EC_number="2.8.3.-" FT /note="Rv3552, (MTCY03C7.03c), len: 250 aa. Possible FT CoA-transferase, beta subunit (EC 2.8.3.-), similar in part FT to other CoA-transferases e.g. Q9I6R1|PA0227 from FT Pseudomonas aeruginosa (260 aa), FASTA scores: opt: 233, FT E(): 8.6e-08, (24.8% identity in 238 aa overlap); FT BAB50894|MLL4181 from Rhizobium loti (Mesorhizobium loti) FT (264 aa), FASTA scores: opt: 210, E(): 2.6e-06, (24.15% FT identity in 203 aa overlap); and AAK41345|Q97Z51|GCTB from FT Sulfolobus solfataricus (245 aa), FASTA scores: opt: 122, FT E(): 1.1, (25.5% identity in 243 aa overlap). POSSIBLY FT BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT B FT FAMILY. Note that this putative protein may combine with FT the putative protein encoded by the upstream ORF Rv3551 to FT form a CoA-transferase that comprises two subunits." FT /db_xref="GOA:P63652" FT /db_xref="UniProtKB/Swiss-Prot:P63652" FT /protein_id="CAB05055.1" FT /translation="MSTRAEVCAVACAELFRDAGEIMISPMTNMASVGARLARLTFAPD FT ILLTDGEAQLLADTPALGKTGAPNRIEGWMPFGRVFETLAWGRRHVVMGANQVDRYGNQ FT NISAFGPLQRPTRQMFGVRGSPGNTINHATSYWVGNHCKRVFVEAVDVVSGIGYDKVDP FT DNPAFRFVNVYRVVSNLGVFDFGGPDHSMRAVSLHPGVTPGDVRDATSFEVHDLDAAEQ FT TRLPTDDELHLIRAVIDPKSLRDREIRS" FT repeat_region complement(174392..174449) FT /note="58 bp Mycobacterial Interspersed Repetitive Unit, FT Class III." FT CDS 174445..175512 FT /transl_table=11 FT /locus_tag="Rv3553" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3553, (MTCY03C7.02c), len: 355 aa. Possible FT oxidoreductase (EC 1.-.-.-), highly similar (except in FT C-terminus) to Q9A327|CC3379 HYPOTHETICAL PROTEIN from FT Caulobacter crescentus (321 aa), FASTA scores: opt: 639, FT E(): 4.6e-29, (46.35% identity in 248 aa overlap); and FT Q9WZQ7|TM0800 CONSERVED HYPOTHETICAL PROTEIN from FT Thermotoga maritima (314 aa), FASTA scores: opt: 622, E(): FT 4.1e-28, (37.95% identity in 340 aa overlap). Also similar FT to two TRANS-2-ENOYL-ACP REDUCTASES; Q99YD4|FABK|SPY1751 FT from Streptococcus pyogenes (323 aa), FASTA scores: opt: FT 604, E(): 4.4e-27, (33.25% identity in 346 aa overlap); and FT Q9FBC5|FABK from Streptococcus pneumoniae (324 aa), FASTA FT scores: opt: 553, E(): 3.3e-24, (32.1% identity in 346 aa FT overlap); and similar with several 2-NITROPROPANE FT DIOXYGENASES, e.g. Q9F7P8 from uncultured proteobacterium FT EBAC31A08 (322 aa), FASTA scores: opt: 505, E(): 1.7e-21, FT (33.6% identity in 348 aa overlap); Q9FMG0 (alias AAK44141) FT from Arabidopsis thaliana (Mouse-ear cress) (333 aa), FASTA FT scores: opt: 489, E(): 1.4e-20, (33.15% identity in 341 aa FT overlap); O28109|AF2173 (NCD2) from Archaeoglobus fulgidus FT (274 aa), FASTA scores: opt: 456, E(): 8.9e-19, (36.3% FT identity in 237 aa overlap); etc." FT /db_xref="GOA:P71847" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR004136" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:P71847" FT /protein_id="CAB05054.1" FT /translation="MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILAS FT ATMTLDELAAAITKVKAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFALAPKQQL FT IARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGGHTGPVATTLLLPSVLDAV FT AGTGIPVIAAGGFFDGRGLAAALCYGAAGVAMGTRFLLTSDSTVPDAVKRRYLQAGLDG FT TVVTTRVDGMPHRVLRTELVEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLT FT MRHGKELTWSQVLMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIV FT LDAITHLQTASALVE" FT CDS 175509..177566 FT /transl_table=11 FT /gene="fdxB" FT /locus_tag="Rv3554" FT /product="POSSIBLE ELECTRON TRANSFER PROTEIN FDXB" FT /function="UNKNOWN; C-TERMINUS PROBABLY INVOLVED IN FT ELECTRON TRANSFER IN ONE OR SEVERAL METABOLIC REACTIONS." FT /EC_number="1.-.-.-" FT /note="Rv3554, (MTCY06G11.01, MTCY03C7.01c), len: 685 aa. FT Possible fdxB, two-domain protein, with ferredoxin FT reductase electron transfer component in C-terminal part FT (EC 1.-.-.-) and unknown function in N-terminal part. FT Indeed, N-terminal end is similar to O85832 HYPOTHETICAL FT 36.1 KDA PROTEIN from Sphingomonas aromaticivorans strain FT F199 (catabolic plasmid pNL1) (309 aa), FASTA scores: opt: FT 615, E(): 2.5e-30, (33.1% identity in 311 aa overlap); and FT P73428|SLL1468 HYPOTHETICAL 36.2 KDA PROTEIN from FT Synechocystis sp. strain PCC 6803 (312 aa), FASTA scores: FT opt: 317, E(): 4.5e-12, (30.2% identity in 268 aa overlap). FT And C-terminal end is similar to Q9F9U6|PAAE protein FT involved in aerobic phenylacetate metabolism from Azoarcus FT evansii (360 aa), FASTA scores: opt: 935, E(): 7e-50, FT (43.85% identity in 351 aa overlap); FT CAC44653|PAAE|SCBAC17A6.08 PUTATIVE PHENYLACETIC ACID FT DEGRADATION NADH OXIDOREDUCTASE from Streptomyces FT coelicolor (368 aa), FASTA scores: opt: 93, E(): 9.5e-50, FT (41.95% identity in 372 aa overlap); Q9FA57|PACI FERREDOXIN FT from Azoarcus evansii (360 aa), FASTA scores: opt: 925, FT E(): 2.9e-49, (43.3% identity in 351 aa overlap); FT P76081|PAAE_ECOLI|B1392 PROBABLE PHENYLACETIC ACID FT DEGRADATION NADH OXIDOREDUCTASE from Escherichia coli FT strains K12 and W (356 aa), FASTA scores: opt: 910, E(): FT 2.4e-48, (43.05% identity in 353 aa overlap); Q9APJ6|PAAE FT ELECTRON TRANSFER PROTEIN (FRAGMENT) from Hyphomicrobium FT chloromethanicum (241 aa), FASTA scores: opt: 404, E(): FT 1.7e-17, (35.45% identity in 234 aa overlap); FT BAB51608|MLL5100 FERREDOXIN from Rhizobium loti FT (Mesorhizobium loti) (365 aa), FASTA scores: opt: 316, E(): FT 5.8e-12, (28.95% identity in 349 aa overlap); etc. FT C-terminus also similar to P96853|Rv3571|MTCY06G11.18 FT PUTATIVE ELECTRON TRANSFER PROTEIN from Mycobacterium FT tuberculosis (358 aa), FASTA scores: opt: 450, E(): FT 3.6e-20, (32.95% identity in 358 aa overlap). Contains FT PS00197 2Fe-2S ferredoxins, iron-sulfur binding region FT signature. BELONGS TO THE 2FE2S PLANT-TYPE FERREDOXIN FT FAMILY. COFACTOR: BINDS A 2FE-2S CLUSTER (BY SIMILARITY)." FT /db_xref="GOA:P71846" FT /db_xref="HSSP:1J7A" FT /db_xref="InterPro:IPR001041" FT /db_xref="InterPro:IPR001433" FT /db_xref="InterPro:IPR005804" FT /db_xref="InterPro:IPR006058" FT /db_xref="InterPro:IPR008333" FT /db_xref="InterPro:IPR012675" FT /db_xref="InterPro:IPR017927" FT /db_xref="InterPro:IPR017938" FT /db_xref="UniProtKB/TrEMBL:P71846" FT /protein_id="CAB05067.1" FT /translation="MTDACQAEYAIAAMSTVEMDQAAPESAAHHPLPDPGESVPRLALP FT TIGIFLATLTAFVGSTTAYISGWIPFWVTIPVNAAVTFVMFTVVHDASHYAISSIRWVN FT GLFGRLAWLFVGPVVAFPAFGYIHIQHHRHSNDDEQDPDTFASHGSLWVLPLRWSMVEY FT FYIKYYLPRGRSRPVIEVAETLVMMTLFLTGLIVAIVTGNFWTLAIVFLIPQRIGLTVL FT AWWFDWLPHHGLEDTQRSNRYRATRNRVGAEWLFTPVLLSQNYHLVHHLHPSVPFYRYL FT RTWRRNEEAYLERNAAISTVFGQQLNPDEYRQWKELNGRLARLLPVRMPARSSSPHAVL FT HRIPVASVDPITADATLVTFAVPEALRDAFRFEPGQHVTVRTDLGGQGIRRNYSICAPA FT TRAQLRIAVKHIPGGAFSTFVANELKAGDVLELMTPTGRFGTPLDPLHRKHYVGLVAGS FT GITPVLSILATTLEIETESRFTLIYGNRTKESTMFRAELDRLESRYADRLEILHVLSSE FT PLHTPELRGRIDRDKLTRWLTSTLRPAGVDEWFICGPLAMATAVRETLIEHGVDSERIH FT LELFYGFDTPPATRPSYAGATVTFTLSGQRAIFDLVPGDSILEGALGLRSDAPYACMGG FT ACGTCRAKLIEGNVEMDHNFALRKAELDAGYILTCQSHPTTPFVAVDYDA" FT misc_feature 177402..177428 FT /note="PS00197 2Fe-2S ferredoxins, iron-sulfur binding FT region signature." FT CDS complement(177654..178523) FT /transl_table=11 FT /locus_tag="Rv3555c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3555c, (MTCY06G11.02c), len: 289 aa. Hypothetical FT protein, highly similar to others from Mycobacterium FT tuberculosis e.g. O53562|AL022022|Rv3517|MTV023.24 (279 FT aa), FASTA scores: opt: 874, E(): 8.3e-48, (49.45% identity FT in 275 aa overlap); P71763|Rv1482c|MTCY277.03c (339 aa), FT FASTA scores: opt: 755, E(): 3e-40, (45.75% identity in 260 FT aa overlap); O69681|Rv3714c|MTV025.062c (296 aa), FASTA FT scores: opt: 733, E(): 6.4e-39, (44.1% identity in 281 aa FT overlap); etc. Also highly similar to other mycobacterial FT hypothetical proteins e.g. O07396|MAV346 from Mycobacterium FT avium (346 aa), FASTA scores: opt: 714, E(): 1.1e-37, FT (44.6% identity in 260 aa overlap); and FT Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa), FT FASTA scores: opt: 130, E(): 0.17, (35.1% identity in 57 aa FT overlap) (only partial homology with this protein). Shows FT some similarity to P52392|NHSR_STRAS PUTATIVE NOSIHEPTIDE FT RESISTANCE REGULATORY PROTEIN (ORF699) from Streptomyces FT actuosus (233 aa), FASTA scores: opt: 120, E(): 1.9, FT (25.25% identity in 194 aa overlap)." FT /db_xref="GOA:P96837" FT /db_xref="InterPro:IPR011335" FT /db_xref="UniProtKB/TrEMBL:P96837" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07157.1" FT /translation="MDELPWPVLGSEVLAAKAIPERAMRQLYEPVYPGVYAPAGVELTA FT RQRAHAAWLWSRRRAVVAGNSAAALLGAKWVNPALDAELVHANRKPPPRIVVHTDRLAP FT HETVAVDGVAVTTPARTAFDIGRRTPSRLQAVQRLDALANSTDVKVADVQAVIAEHTGA FT RGLVRLRAVLPLIDGGAESPQETWTRLVLIDAGLPKPQTQIRVFDDYGDFVARIDLGYE FT QLRVGVEYDGPQHWTDPAQRARDIERSTALLDLGWTIIRVTSELLWYRRGTFVGRVDAA FT MRAAGWRP" FT CDS complement(178628..179788) FT /transl_table=11 FT /gene="fadA6" FT /locus_tag="Rv3556c" FT /product="PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6 FT (ACETOACETYL-CoA THIOLASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION FT [CATALYTIC ACTIVITY: 2 ACETYL-CoA = CoA + FT ACETOACETYL-COA]." FT /EC_number="2.3.1.9" FT /note="Rv3556c, (MTCY06G11.03), len: 386 aa. Probable FT fadA6, acetyl-CoA acetyltransferase (EC 2.3.1.9), similar FT to many e.g. Q9K409|2SCG61.06c from Streptomyces coelicolor FT (389 aa), FASTA scores: opt: 1091, E(): 2.9e-58, (48.1% FT identity in 399 aa overlap); Q9AAT4|CC0510 from Caulobacter FT crescentus (391 aa), FASTA scores: opt: 902, E(): 6.6e-47, FT (40.25% identity in 395 aa overlap); P45359|THL_CLOAB from FT Clostridium acetobutylicum (392 aa), FASTA scores: opt: FT 872, E(): 4.2e-45, (37.9% identity in 396 aa overlap); FT Q9I2A8|ATOB|PA2001 from Pseudomonas aeruginosa (393 aa), FT FASTA scores: opt: 872, E(): 4.2e-45, (41.3% identity in FT 397 aa overlap); etc. Contains PS00737 Thiolases signature FT 2. BELONGS TO THE THIOLASE FAMILY." FT /db_xref="GOA:P96838" FT /db_xref="HSSP:1AFW" FT /db_xref="InterPro:IPR002155" FT /db_xref="InterPro:IPR016038" FT /db_xref="InterPro:IPR016039" FT /db_xref="InterPro:IPR020613" FT /db_xref="InterPro:IPR020616" FT /db_xref="InterPro:IPR020617" FT /db_xref="UniProtKB/TrEMBL:P96838" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07158.1" FT /translation="MTEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDIDP FT AAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIM FT SGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGSEL FT IAEKWNLSREEMERYSLTSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRESSLEK FT MAGLQPLVEGGRLTAAMASQISDGASAVLLASERAVKDHGLRPRARIHHISARAADPVF FT MLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVMAWLKEIKADPAKVNPNGGAIAL FT GHPLGATGAKLFTTMLGELERIGGRYGLQTMCEGGGTANVTIIERL" FT misc_feature complement(178745..178795) FT /note="PS00737 Thiolases signature 2." FT CDS complement(179853..180455) FT /transl_table=11 FT /locus_tag="Rv3557c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv3557c, (MTCY06G11.04c), len: 200 aa. Probable FT transcriptional regulator, tetR family, similar to other FT e.g. Q9RRV9|DR2376 from Deinococcus radiodurans (197 aa) FT FASTA scores: opt: 326, E(): 2.3e-14, (31.2% identity in FT 189 aa overlap); Q9HZW2|PA2885 from Pseudomonas aeruginosa FT (198 aa), FASTA scores: opt: 308, E(): 3.5e-13, (31.55% FT identity in 187 aa overlap); Q9RFR4 from Pseudomonas FT fluorescens (207 aa), FASTA scores: opt: 291, E(): 4.7e-12, FT (29.75% identity in 195 aa overlap); Q9K8P5|BH2958 from FT Bacillus halodurans (215 aa), FASTA scores: opt: 271, E(): FT 9.9e-11, (23.95% identity in 192 aa overlap); etc. Also FT similar to proteins from Mycobacterium tuberculosis e.g. FT O53641|Rv0158|MTV032.01 (214 aa), FASTA scores: opt: 232, FT E(): 3.5e-08, (25.5% identity in 192 aa overlap); and FT O06169|Rv2506|MTCY07A7.12 (215 aa), FASTA scores: opt: 215, FT E(): 4.5e-07, (35.15% identity in 148 aa overlap); etc. FT SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL FT REGULATORS." FT /db_xref="GOA:P96839" FT /db_xref="InterPro:IPR001647" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR011075" FT /db_xref="InterPro:IPR012287" FT /db_xref="InterPro:IPR015893" FT /db_xref="UniProtKB/TrEMBL:P96839" FT /protein_id="CAB07159.1" FT /translation="MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSG FT SLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTANPLERLQGLFMASFEAIEHHHAQ FT VVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRD FT TTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV" FT CDS 180804..182462 FT /transl_table=11 FT /gene="PPE64" FT /locus_tag="Rv3558" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv3558, (MTCY06G11.05), len: 552 aa. Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, similar to many e.g. P71868|Rv3533c|MTCY03C7.23 FT (582 aa), FASTA scores: opt: 1908, E(): 1.7e-83, (58.5% FT identity in 583 aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q6MWW0" FT /protein_id="CAE55613.1" FT /translation="MAHFSVLPPEINSLRMYLGAGSAPMLQAAAAWDGLAAELGTAASS FT FSSVTTGLTGQAWQGPASAAMAAAAAPYAGFLTTASAQAQLAAGQAKAVASVFEAAKAA FT IVPPAAVAANREAFLALIRSNWLGLNAPWIAAVESLYEEYWAADVAAMTGYHAGASQAA FT AQLPLPAGLQQFLNTLPNLGIGNQGNANLGGGNTGSGNIGNGNKGSSNLGGGNIGNNNI FT GSGNRGSDNFGAGNVGTGNIGFGNQGPIDVNLLATPGQNNVGLGNIGNNNMGFGNTGDA FT NTGGGNTGNGNIGGGNTGNNNFGFGNTGNNNIGIGLTGNNQMGINLAGLLNSGSGNIGI FT GNSGTNNIGLFNSGSGNIGVFNTGANTLVPGDLNNLGVGNSGNANIGFGNAGVLNTGFG FT NASILNTGLGNAGELNTGFGNAGFVNTGFDNSGNVNTGNGNSGNINTGSWNAGNVNTGF FT GIITDSGLTNSGFGNTGTDVSGFFNTPTGPLAVDVSGFFNTASGGTVINGQTSGIGNIG FT VPGTLFGSVRSGLNTGLFNMGTAISGLFNLRQLLG" FT CDS complement(182471..183259) FT /transl_table=11 FT /locus_tag="Rv3559c" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3559c, (MTCY06G11.06c), len: 262 aa. Probable FT oxidoreductase (EC 1.-.-.-), similar to various FT oxidoreductases e.g. Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE FT 3-KETO-ACYL-REDUCTASE (SDR FAMILY) from Streptomyces FT antibioticus (273 aa), FASTA scores: opt: 510, E(): FT 2.8e-24, (40.15% identity in 249 aa FT overlap);Q9L2C9|SC7A8.29 PUTATIVE DEHYDROGENASE from FT Streptomyces coelicolor (255 aa), FASTA scores: opt: 500, FT E(): 1.1e-23, (41.4% identity in 239 aa overlap); FT Q9HQ41|FABG|VNG1341G 3-OXOACYL-[ACYL-CARRIER-PROTEIN] FT REDUCTASE from Halobacterium sp. strain NRC-1 (255 aa) FT FASTA scores: opt: 500, E(): 1.1e-23, (40.0% identity in FT 250 aa overlap); etc. Also similar to oxidoreductases from FT Mycobacterium tuberculosis eg FT Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE FT OXIDOREDUCTASE (247 aa), FASTA scores: opt: 497, E(): FT 1.6e-23, (39.2% identity in 245 aa overlap)." FT /db_xref="GOA:P96841" FT /db_xref="HSSP:1AE1" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P96841" FT /protein_id="CAB07134.1" FT /translation="MNLSVAPKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGAD FT VVISDHHERRLGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMGRLDVLVNN FT AGLGGQTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAPHGGVIVNNASVLGWRA FT QHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSIARHKFLDKTASAELLDRLAA FT GEAFGRAAEPWEVAATIAFLASDYSSYLTGEVISVSCQHP" FT CDS complement(183256..184413) FT /transl_table=11 FT /gene="fadE30" FT /locus_tag="Rv3560c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE30" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv3560c, (MTCY06G11.07c), len: 385 aa. Probable FT fadE30, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 FT aa), FASTA scores: opt: 845, E(): 1.6e-47, (39.2% identity FT in 388 aa overlap); Q9A5G9|CC2478 from Caulobacter FT crescentus (407 aa), FASTA scores: opt: 734, E(): 2.8e-40, FT (35.5% identity in 386 aa overlap); Q9RJX2|SCF37.29c from FT Streptomyces coelicolor (393 aa), FASTA scores: opt: 656, FT E(): 3.2e-35, (37.9% identity in 351 aa overlap); etc. Also FT similar to acyl-CoA dehydrogenases from Mycobacterium FT tuberculosis e.g. P95280|FADE17|Rv1934c|MTCY09F9.30 (409 FT aa), FASTA scores: opt: 939, E(): 1.4e-53, (43.8% identity FT in 404 aa overlap). COULD BELONG TO THE ACYL-COA FT DEHYDROGENASES FAMILY." FT /db_xref="GOA:P96842" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006091" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:P96842" FT /protein_id="CAB07135.1" FT /translation="MQDVEEFRAQVRGWLADNLAGEFAALKGLGGPGREHEAFEERRAW FT NQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARADAPDKVNHFGEELLGPTLIAF FT GTPQQQRRFLPRIRDVTELWCQGYSEPGAGSDLASVATTAELDGDQWVINGQKVWTSLA FT HLSQWCFVLARTEKGSQRHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTD FT ADLVVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADDPLIRER FT LTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWANWHRNLGELAMDVIGKPGMTM FT PDGEFDEWQRLYLFTRADTIYGGSNEIQRNIIAERVLGLPREAKG" FT CDS 184461..185984 FT /transl_table=11 FT /gene="fadD3" FT /locus_tag="Rv3561" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD3 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv3561, (MTCY06G11.08), len: 507. Probable fadD3, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT substrate-CoA symthetases/ligases e.g. Q9KBC2|BH2006 FT LONG-CHAIN ACYL-CoA SYNTHETASE from Bacillus halodurans FT (513 aa), FASTA scores: opt: 821, E(): 1.6e-43, (32.9% FT identity in 517 aa overlap); Q9EY88|FCS FERULOYL-COA FT SYNTHETASE from Amycolatopsis sp. HR167 (491 aa) FASTA FT scores: opt: 767, E(): 3.5e-40, (37.65% identity in 502 aa FT overlap); Q9ZIP5|MATB MALONYL CoA SYNTHETASE from Rhizobium FT leguminosarum (504 aa), FASTA scores: opt: 758, E(): FT 1.3e-39, (33.7% identity in 472 aa overlap); FT Q9CD27|FADD2|ML2546 ACYL-CoA SYNTHASE from Mycobacterium FT leprae (548 aa), FASTA scores: opt: 700, E(): 5.6e-36, FT (31.85% identity in 515 aa overlap); FT P29212|LCFA_ECOLI|FADD|OLDD|B1805 FT LONG-CHAIN-FATTY-ACID--CoA LIGASE from Escherichia coli FT strain K12 (561 aa), FASTA scores: opt: 532, E(): 6.3e-28, FT (30.0% identity in 533 aa overlap); etc. Also similar to FT other from Mycobacterium tuberculosis eg FT O53306|FADD13|Rv3089|MTV013.10 (503 aa), FASTA scores: opt: FT 819, E(): 2.1e-43, (35.1% identity in 490 aa overlap). FT Contains PS00455 Putative AMP-binding domain signature." FT /db_xref="GOA:P96843" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="InterPro:IPR020845" FT /db_xref="UniProtKB/TrEMBL:P96843" FT /protein_id="CAB07136.1" FT /translation="MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAA FT AALIALGVEPADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGA FT PVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARA FT AAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHN FT FGYKAGILACLQTGATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDF FT DLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVAT FT TCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAG FT NLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARP FT GTGLDEASVIAYTREHLANFKTPRSVRFVDVLPRNAAGKVSKPQLRELG" FT misc_feature 184980..185015 FT /note="PS00455 Putative AMP-binding domain signature." FT CDS 185985..187118 FT /transl_table=11 FT /gene="fadE31" FT /locus_tag="Rv3562" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE31" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv3562, (MTCY06G11.09), len: 377 aa. Probable FT fadE31, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor FT (393 aa), FASTA scores: opt: 657, E(): 1.7e-34, (36.45% FT identity in 351 aa overlap); Q9A5G9|CC2478 from Caulobacter FT crescentus (407 aa), FASTA scores: opt: 653, E(): 3.2e-34, FT (33.95% identity in 392 aa overlap); Q9EX72|MLHC from FT Rhodococcus erythropolis (324 aa) FASTA scores: opt: 631, FT E(): 6.5e-33, (36.95% identity in 330 aa overlap); FT P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa), FT FASTA scores: opt: 347, E(): 1e-15, (28.6% identity in 385 FT aa overlap); etc. Also similar to other from Mycobacterium FT tuberculosis e.g. P96842|FADE30|Rv3560c|MTCY06G11.07c (385 FT aa), FASTA scores: opt: 843, E(): 2.3e-46, (38.95% identity FT in 380 aa overlap). COULD BELONG TO THE ACYL-CoA FT DEHYDROGENASES FAMILY." FT /db_xref="GOA:P96844" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006091" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:P96844" FT /protein_id="CAB07137.1" FT /translation="MDLNFDDETLAFQAEVREFLAANAASIPTKSYDNAEGFAQHRYWD FT RVLFDAGLSVITWPAKYGGRDAPLLHWIVFEEEYFRAGAPGRASANGTSMLAPTLFAHG FT TAEQLDRILPKMASGEQIWAQAWSEPESGSDLASLRSTASKVDGGWLLNGQKIWSSRAP FT FADMGFGLFRSDPAVERHRGLTYFMFDLKAKGVTVRPIAQLGGDTGFGEIFLDDVFVPD FT RDVIGAPNDGWRAAMSTSSNERGMSLRSPARFLASAERLVQLWKDRGSPPEFADRVADA FT WIKAQAYRLQTFGTVTRLAAGGELGAESSVTKVFWSELDVHLHQTALDLRGADGELAGP FT WTEGLLFALGGPIYAGTNEIQRNIIAERLLGLPREKT" FT CDS 187115..188074 FT /transl_table=11 FT /gene="fadE32" FT /locus_tag="Rv3563" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE32" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv3563, (MTCY06G11.10), len: 319 aa. Probable FT fadE32, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 FT aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15% identity FT in 333 aa overlap); Q9RJX3|SCF37.28c from Streptomyces FT coelicolor (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, FT (32.4% identity in 349 aa overlap); Q9A5G8|CC2479 from FT Caulobacter crescentus (344 aa), FASTA scores: opt: 285, FT E(): 4.1e-10, (30.4% identity in 329 aa overlap); FT P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FT FASTA scores: opt: 230, E(): 1.1e-07, (25.5% identity in FT 357 aa overlap); etc. Also similar to other from FT Mycobacterium tuberculosis eg FT P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa), FASTA scores: FT opt: 478, E(): 7.6e-22, (32.9% identity in 292 aa overlap). FT COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY." FT /db_xref="GOA:P96845" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:P96845" FT /protein_id="CAB07138.1" FT /translation="MTMEFALNEQQRDFAASIDAALGAADLPGVVRAWAAGDVAPGRKV FT WQQLANLGVTALGVAEKFDGLGASPVDLVVALERLGRWCVPGPVTESIAVAPILLAHDD FT QAERSHGLASGELIATVAMPPRVPRAVDADTAGLVLLAGDGSVTEGTPGDCHRSVDPSR FT RLYEVAASGQAWRAPKDVVARAYEFGALATAAQLVGAGQALLEAAVNYAKQRTQFGRAI FT GSYQAIKHKLADVHIAIELACPLVYGAAVSLEPRDVSAAKAAASEAALLAARWALQTHG FT AIGFTCEHDLSLWLLRVQALHSAWGTPQEHRRRVLEAL" FT CDS 188071..189027 FT /transl_table=11 FT /gene="fadE33" FT /locus_tag="Rv3564" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE33" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv3564, (MTCY06G11.11), len: 318 aa. Probable FT fadE33, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT others e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 FT aa), FASTA scores: opt: 373, E(): 1.9e-15, (34.3% identity FT in 338 aa overlap); Q9I4V4|PA1020 from Pseudomonas FT aeruginosa (370 aa), FASTA scores: opt: 277, E(): 1.4e-09, FT (31.95% identity in 335 aa overlap); Q9X7Y6|SC6A5.40c from FT Streptomyces coelicolor (395 aa), FASTA scores: opt: 273, FT E(): 2.5e-09, (30.1% identity in 352 aa overlap); FT P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FT FASTA scores: opt: 478, E(): 7.9e-22, (32.9% identity in FT 292 aa overlap); etc. Also similar to others from FT Mycobacterium tuberculosis e.g. FT P96845|FADE32|Rv3563|MTCY06G11.10 (319 aa), FASTA scores: FT opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa overlap). FT COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY." FT /db_xref="GOA:P96846" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:P96846" FT /protein_id="CAB07139.1" FT /translation="MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDRGYDESLWRLL FT CEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLGTTLAELALLAAAKPDA FT QALTELAQGSAIGALVLDPDYVVNGDIADIVVAATSGQLTRWTRFSAQPVATMDPTRRL FT ARLQSEETEPLCPDPGIADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQA FT LKHRMADLYVTIAAARAVVADACHAPTPTNAATARLAASEALSTAAAEGIQLHGGIAIT FT WEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP" FT CDS 189024..190190 FT /transl_table=11 FT /gene="aspB" FT /locus_tag="Rv3565" FT /product="POSSIBLE ASPARTATE AMINOTRANSFERASE ASPB FT (TRANSAMINASE A) (ASPAT) (GLUTAMIC--OXALOACETIC FT TRANSAMINASE) (GLUTAMIC--ASPARTIC TRANSAMINASE)" FT /function="THOUGHT TO BE INVOLVED IN GLUTAMATE BIOSYNTHESIS FT [CATALYTIC ACTIVITY: L-ASPARTATE + 2-OXOGLUTARATE = FT OXALOACETATE + L-GLUTAMATE]." FT /EC_number="2.6.1.1" FT /note="Rv3565, (MTCY06G11.12), len: 388 aa. Possible aspB, FT aspartate aminotransferase (EC 2.6.1.1), similar to many FT e.g. Q9A5J2|CC2455 AMINOTRANSFERASE CLASS I from FT Caulobacter crescentus (381 aa), FASTA scores: opt: 1112, FT E(): 1e-61, (45.85% identity in 384 aa overlap); FT Q9HV76|PA4722 PROBABLE AMINOTRANSFERASE from Pseudomonas FT aeruginosa (390 aa), FASTA scores: opt: 863, E(): 3.1e-46, FT (37.2% identity in 390 aa overlap); Q9RWP3|DR0623 ASPARTATE FT AMINOTRANSFERASE from Deinococcus radiodurans (388 aa), FT FASTA scores: opt: 713, E(): 6.3e-37, (35.5% identity in FT 383 aa overlap); Q9HQK2|ASPC2|VNG1121G ASPARTATE FT AMINOTRANSFERASE from Halobacterium sp. strain NRC-1 (391 FT aa), FASTA scores: opt: 710, E(): 9.8e-37, (34.45% identity FT in 380 aa overlap); O33822|AAT_THEAQ|ASPC ASPARTATE FT AMINOTRANSFERASE from Thermus aquaticus (383 aa), FASTA FT scores: opt: 695, E(): 8.2e-36, (35.1% identity in 376 aa FT overlap); etc. Contains PS00105 Aminotransferases class-I FT pyridoxal-phosphate attachment site. BELONGS TO CLASS-I OF FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: FT PYRIDOXAL PHOSPHATE (BY SIMILARITY)." FT /db_xref="GOA:P96847" FT /db_xref="HSSP:5BJ4" FT /db_xref="InterPro:IPR001176" FT /db_xref="InterPro:IPR004838" FT /db_xref="InterPro:IPR004839" FT /db_xref="InterPro:IPR015421" FT /db_xref="InterPro:IPR015424" FT /db_xref="UniProtKB/TrEMBL:P96847" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07140.1" FT /translation="MTDRVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGA FT PEPVRAAAAAALHLNQLGYSVALGIPELRDAIAADYQRRHGITVEPDAVVITTGSSGGF FT LLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQMLAEIDPP FT LRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQGAPQTSCAWQT FT SRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTP FT EATAEADGNLASYAINRSLLLDGLRRIGIDRLAPTDGAFYVYADVSDFTSDSLAFCSKL FT LADTGVAIAPGIDFDTARGGSFVRISFAGPSGDIEEALRRIGSWLPSQ" FT misc_feature 189714..189755 FT /note="PS00105 Aminotransferases class-I FT pyridoxal-phosphate attachment site." FT CDS complement(190155..191006) FT /transl_table=11 FT /gene="nat" FT /locus_tag="Rv3566c" FT /standard_name="nhoA" FT /product="ARYLAMINE N-ACETYLTRANSFERASE NAT (ARYLAMINE FT ACETYLASE)" FT /function="COULD HAVE A ROLE IN ACETYLATING, AND HENCE FT INACTIVATING, THE ANTITUBERCULAR DRUG ISONIAZID [CATALYTIC FT ACTIVITY: ACETYL-CoA + ARYLAMINE = CoA + FT N-ACETYLARYLAMINE]." FT /EC_number="2.3.1.5" FT /note="Rv3566c, (MT3671, MTCY06G11.13c), len: 283 aa. nat FT (alternate gene name: nhoA), arylamine N-acetyltransferase FT (EC 2.3.1.5) (see citations below), highly similar to FT O86309|NAT_MYCSM ARYLAMINE N-ACETYLTRANSFERASE from FT Mycobacterium smegmatis (see citation below) (275 aa), FT FASTA scores: opt: 1114, E(): 3e-66, (60.95% identity in FT 274 aa overlap). Also highly similar to others e.g. FT Q98D42|BAB51429|MLR4870 from Rhizobium loti (Mesorhizobium FT loti) (278 aa), FASTA scores: opt: 697, E(): 1.1e-38, FT (44.1% identity in 272 aa overlap); P77567|NHOA_ECOLI|B1463 FT from Escherichia coli strain K12 (281 aa), FASTA scores: FT opt: 537, E(): 4.4e-28, (38.85% identity in 273 aa FT overlap); Q00267|NHOA_SALTY from Salmonella typhimurium FT (281 aa), FASTA scores: opt: 507, E(): 4.3e-26, (34.8% FT identity in 273 aa overlap); etc. BELONGS TO THE ARYLAMINE FT N-ACETYLTRANSFERASE FAMILY. Note that previously known as FT nhoA (332 aa) and that nucleotide 4007874 has been changed FT since first submission (G deleted)." FT /db_xref="GOA:P0A5L8" FT /db_xref="InterPro:IPR001447" FT /db_xref="UniProtKB/Swiss-Prot:P0A5L8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55614.1" FT /translation="MALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPLL FT GVPVDDLSPQALADKLVLRRRGGYCFEHNGLMGYVLAELGYRVRRFAARVVWKLAPDAP FT LPPQTHTLLGVTFPGSGGCYLVDVGFGGQTPTSPLRLETGAVQPTTHEPYRLEDRVDGF FT VLQAMVRDTWQTLYEFTTQTRPQIDLKVASWYASTHPASKFVTGLTAAVITDDARWNLS FT GRDLAVHRAGGTEKIRLADAAAVVDTLSERFGINVADIGERGALETRIDELLARQPGAD FT AP" FT CDS complement(190991..191257) FT /transl_table=11 FT /locus_tag="Rv3566A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv3566A, len: 88 aa. Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q8VIX9" FT /protein_id="CAE55615.1" FT /translation="MSGADPPTRRAFGQMARAATGWVSVSGQFAVAADTCRCEGTLFAV FT DPETHVANHNRCDIVGRLRDERPNTLRSVRRGDEVRMATWHWI" FT CDS complement(191543..192106) FT /transl_table=11 FT /locus_tag="Rv3567c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3567c, (MTCY06G11.14c), len: 187 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to various FT oxidoreductases and hypothetical proteins e.g. O69360 ORF61 FT PROTEIN from Rhodococcus erythropolis (194 aa) FASTA FT scores: opt: 974, E(): 3e-59, (77.05% identity in 183 aa FT overlap); Q9JN75|MMYF PUTATIVE OXIDOREDUCTASE from FT Streptomyces coelicolor (174 aa), FASTA scores: opt: 451, FT E(): 1e-23, (43.65% identity in 158 aa overlap); FT P54990|NTAB_CHEHE|NMOB NITRILOTRIACETATE MONOOXYGENASE FT COMPONENT B (EC 1.14.13.-) from Chelatobacter heintzii (322 FT aa), FASTA scores: opt: 409, E(): 1.3e-20, (38.3% identity FT in 167 aa overlap)Chelatobacter heintzii; AAK62356 PUTATIVE FT NADH:FMN OXIDOREDUCTASE from Burkholderia sp. DBT1 (177 FT aa), FASTA scores: opt: 360, E(): 1.6e-17, (36.15% identity FT in 155 aa overlap)." FT /db_xref="GOA:P96849" FT /db_xref="InterPro:IPR002563" FT /db_xref="InterPro:IPR009002" FT /db_xref="InterPro:IPR012349" FT /db_xref="UniProtKB/TrEMBL:P96849" FT /protein_id="CAB07141.1" FT /translation="MSAQIDPRTFRSVLGQFCTGITVITTVHDDVPVGFACQSFAALSL FT EPPLVLFCPTKVSRSWQAIEASGRFCVNVLTEKQKDVSARFGSKEPDKFAGIDWRPSEL FT GSPIIEGSLAYIDCTVASVHDGGDHFVVFGAVESLSEVPAVKPRPLLFYRGDYTGIEPE FT KTTPAHWRDDLEAFLITTTQDTWL" FT CDS complement(192121..193023) FT /transl_table=11 FT /gene="bphC" FT /locus_tag="Rv3568c" FT /product="PROBABLE BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE BPHC FT (23OHBP OXYGENASE) (2,3-DIHYDROXYBIPHENYL DIOXYGENASE) FT (2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE) (DHBD)" FT /function="INVOLVED IN THE DEGRADATION OF BIPHENYL FT [CATALYTIC ACTIVITY: BIPHENYL-2,3-DIOL + O(2) = FT 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE + H(2)O]." FT /EC_number="1.13.11.39" FT /note="Rv3568c, (MTCY06G11.15c), len: 300 aa. Probable FT bphC, 2,3-dihydroxybiphenyl 1,2-dioxygenase (EC FT 1.13.11.39), highly similar to other e.g. Q9KWQ5|BPHC5 from FT Rhodococcus sp. RHA1 (300 aa), FASTA scores: opt: 1715, FT E(): 3.8e-103, (82.15% identity in 297 aa overlap); FT O50479|EDOB from Rhodococcus rhodochrous (300 aa) FASTA FT scores: opt: 1714, E(): 4.4e-103, (82.5% identity in 297 aa FT overlap); O69359|BPHC6 from Rhodococcus erythropolis (300 FT aa), FASTA scores: opt: 1647, E(): 9.1e-99, (78.25% FT identity in 299 aa overlap); Q9RBT2|BPHC1 from Pseudomonas FT sp. SY5 (301 aa) Pseudomonas sp. SY5 (298 aa) FASTA scores: FT opt: 767, E(): 3.9e-42, (42.8% identity in 299 aa overlap); FT P47228|BPHC_BURCE from Burkholderia cepacia (Pseudomonas FT cepacia) (297 aa), FASTA scores: opt: 670, E(): 6.8e-36, FT (40.55% identity in 296 aa overlap); etc. Contains PS00082 FT Extradiol ring-cleavage dioxygenases signature. BELONGS TO FT THE EXTRADIOL RING-CLEAVAGE DIOXYGENASE FAMILY." FT /db_xref="GOA:P96850" FT /db_xref="InterPro:IPR000486" FT /db_xref="InterPro:IPR004360" FT /db_xref="PDB:2ZI8" FT /db_xref="PDB:2ZYQ" FT /db_xref="UniProtKB/TrEMBL:P96850" FT /protein_id="CAB07142.1" FT /translation="MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMD FT DFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEATAAELADRRVDEM FT IRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVVLSTRDDAEALHFYRDV FT LGFRLRDSMRLPPQMVGRPADGPPAWLRFFGCNPRHHSLAFLPMPTSSGIVHLMVEVEQ FT ADDVGLCLDRALRRKVPMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIA FT RESTAVSLWGHDFTVGARG" FT misc_feature complement(192226..192291) FT /note="PS00082 Extradiol ring-cleavage dioxygenases FT signature." FT CDS complement(193020..193895) FT /transl_table=11 FT /gene="bphD" FT /locus_tag="Rv3569c" FT /product="2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE FT HYDROLASE BPHD" FT /function="INVOLVED IN THE DEGRADATION OF BIPHENYL." FT /EC_number="3.7.1.-" FT /note="Rv3569c, (MTCY06G11.16c), len: 291 aa. Probable FT bphD, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase FT (EC 3.7.1.-), highly similar to others e.g. Q9KWQ6|BPHD2 FT from Rhodococcus sp. RHA1 (292 aa), FASTA scores: opt: FT 1468, E(): 1.3e-85, (75.5% identity in 294 aa overlap); FT Q52036 from Pseudomonas putida (286 aa), FASTA scores: opt: FT 785, E(): 1.9e-42, (45.1% identity in 295 aa overlap); FT Q52011|BPHD from Pseudomonas pseudoalcaligenes (286 aa), FT FASTA scores: opt: 774, E(): 9.3e-42, (44.05% identity in FT 295 aa overlap); P47229|BPHD_BURCE from Burkholderia FT cepacia (Pseudomonas cepacia) (286 aa) FASTA scores: opt: FT 772, E(): 1.2e-41, (44.5% identity in 295 aa overlap); etc. FT Contains PS00017 ATP/GTP-binding site motif A. SIMILAR TO FT ALPHA/BETA HYDROLASE FOLD." FT /db_xref="GOA:P96851" FT /db_xref="InterPro:IPR000073" FT /db_xref="PDB:2VF2" FT /db_xref="PDB:2WUD" FT /db_xref="PDB:2WUE" FT /db_xref="PDB:2WUF" FT /db_xref="PDB:2WUG" FT /db_xref="UniProtKB/TrEMBL:P96851" FT /protein_id="CAB07143.1" FT /translation="MTATEELTFESTSRFAEVDVDGPLKLHYHEAGVGNDQTVVLLHGG FT GPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQLG FT LGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSV FT APTRENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAGADFEAGMM FT WREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNK FT LTIEFLGGGR" FT misc_feature complement(193263..193286) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT CDS complement(193910..195094) FT /transl_table=11 FT /locus_tag="Rv3570c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv3570c, (MTCY06G11.17c), len: 394 aa. Possible FT oxidoreductase (EC 1.-.-.-), most similar to hydroxylases FT and oxygenases (and also some similarity to acyl-coa FT dehydrogenases) e.g. O69349 HYDROXYLASE from Rhodococcus FT erythropolis (393 aa), FASTA scores: opt: 958, E(): FT 1.1e-53, (39.95% identity in 383 aa overlap); FT P26698|PIGM_RHOSO PIGMENT PROTEIN from Rhodococcus sp. FT strain ATCC 21145 (387 aa), FASTA scores: opt: 665, E(): FT 5.4e-35, (32.2% identity in 382 aa overlap); Q9ZGA9|LANZ5 FT OXYGENASE HOMOLOG from Streptomyces cyanogenus (397 aa) FT FASTA scores: opt: 588, E(): 4.5e-30, (30.55% identity in FT 386 aa overlap); Q9F0J3|NCNH HYDROXYLASE from Streptomyces FT arenae (405 aa), FASTA scores: opt: 580, E(): 1.5e-29, FT (31.25% identity in 336 aa overlap); O69789|BPFA INDOLE FT DIOXYGENASE from Rhodococcus opacus (399 aa), FASTA scores: FT opt: 558, E(): 3.7e-28, (31.8% identity in 387 aa overlap); FT etc." FT /db_xref="GOA:P96852" FT /db_xref="InterPro:IPR006091" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013107" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:P96852" FT /protein_id="CAB07144.1" FT /translation="MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKALD FT DVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQRAQ FT EEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRP FT VDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLA FT TNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKV FT RIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIASIDRL FT FEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPGDTMV" FT CDS 195241..196317 FT /transl_table=11 FT /gene="hmp" FT /locus_tag="Rv3571" FT /product="POSSIBLE HEMOGLOBINE-RELATED PROTEIN HMP" FT /function="MAY PLAY A ROLE IN PROTECTION FROM OXIDATIVE FT (NITRIC OXIDE) AND NITROSATIVE STRESS. MAY ALSO BE INVOLVED FT IN ANAEROBIC METABOLISM. COULD HAVE NITRIC OXIDE FT DIOXYGENASE ACTIVITY." FT /EC_number="1.-.-.-" FT /note="Rv3571, (MTCY06G11.18), len: 358 aa. Possible hmp, FT oxidoreductase, hemoglobine-related protein (see citation FT below) (EC 1.-.-.-), similar to several e.g. Q44253|ATDA5 FT ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter FT sp (336 aa) FASTA scores: opt: 748, E(): 1.5e-38, (34.95% FT identity in 346 aa overlap); P95533|TDNB ELECTRON TRANSFER FT PROTEIN from Pseudomonas putida (337 aa), FASTA scores: FT opt: 723, E(): 5.2e-37, (36.35% identity in 341 aa FT overlap); AAK65059|SMA0752 POSSIBLE DIOXYGENASE REDUCTASE FT SUBUNIT from Rhizobium meliloti (Sinorhizobium meliloti) FT (353 aa) FASTA scores: opt: 495, E(): 4.9e-23, (31.9% FT identity in 345 aa overlap); P76081|PAAE_ECOLI|B1392 FT PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE FT (356 aa), FASTA scores: opt: 364, E(): 5.1e-15, (34.45% FT identity in 357 aa overlap); Q9L131|HMPA FLAVOHEMOPROTEIN FT from Streptomyces coelicolor (398 aa), FASTA scores: opt: FT 352, E(): 3e-14, (32.8% identity in 247 aa overlap); etc. FT Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding FT region signature. Note that it has been shown hmp FT transcription increased at early stationary phase and is FT lower at late stationary phase and during exponential FT growth." FT /db_xref="GOA:P96853" FT /db_xref="HSSP:1AWD" FT /db_xref="HSSP:2CJO" FT /db_xref="InterPro:IPR001041" FT /db_xref="InterPro:IPR001221" FT /db_xref="InterPro:IPR001433" FT /db_xref="InterPro:IPR001709" FT /db_xref="InterPro:IPR006058" FT /db_xref="InterPro:IPR008333" FT /db_xref="InterPro:IPR012675" FT /db_xref="InterPro:IPR017927" FT /db_xref="InterPro:IPR017938" FT /db_xref="UniProtKB/TrEMBL:P96853" FT /experiment="experimental evidence, no additional details FT |