EBI Dbfetch

ID   BX842582; SV 1; linear; genomic DNA; STD; PRO; 349563 BP.
XX
AC   BX842582; AL009198; AL021646; AL021840-AL021841; Z77165; Z83867; Z92771;
AC   Z95120-Z95121; Z95150; Z96070;
XX
DT   21-NOV-2003 (Rel. 77, Created)
DT   23-OCT-2008 (Rel. 97, Last updated, Version 6)
XX
DE   Mycobacterium tuberculosis H37Rv complete genome; segment 11/13
XX
KW   complete genome.
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
XX
RN   [1]
RX   DOI; 10.1038/31159
RX   PUBMED; 9634230.
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence";
RL   Nature 393(6685):537-544(1998).
XX
RN   [2]
RX   PUBMED; 12368430.
RA   Camus J.C., Pryor M.J., Medigue C., Cole S.T.;
RT   "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv";
RL   Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002).
XX
RN   [3]
RP   1-349563
RA   Parkhill J.;
RT   ;
RL   Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases.
RL   Submitted on behalf of the Mycobacterium tuberculosis sequencing and
RL   mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton,
RL   Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut
RL   Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
RL   parkhill@sanger.ac.uk
XX
DR   EMBL-CON; AL123456.
DR   RFAM; RF00634; SAM-IV.
XX
CC   Notes:
CC   Details of M. tuberculosis sequencing at the Sanger Centre
CC   are available on the World Wide Web.
CC   (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/)
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..349563
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:83332"
FT   misc_RNA        complement(150..756)
FT                   /gene="ssr"
FT                   /product="10Sa RNA"
FT                   /function="INVOLVED IN DEGRADATION OF PROTEINS ENCODED BY
FT                   ABNORMAL MESSENGER RNA."
FT                   /note="ssr, len: 607 nt. Match to EM_BA:MT10SARNA X60301
FT                   M.tuberculosis gene for 10Sa RNA."
FT   CDS             complement(750..1601)
FT                   /transl_table=11
FT                   /locus_tag="Rv3099c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3099c, (MTCY164.10c), len: 283 aa. Conserved
FT                   hypothetical protein, some similarity with hypothetical
FT                   proteins e.g. Q9XA69|SCGD3.09 from Streptomyces coelicolor
FT                   (274 aa), FASTA scores: opt: 384, E(): 1.8e-17, (32.7%
FT                   identity in 269 aa overlap); and P71606|Y036_MYCTU|Rv0036c
FT                   from Mycobacterium tuberculosis strain H37Rv (257 aa),
FT                   FASTA scores: opt: 179, E(): 0.00024, (25.85% identity in
FT                   205 aa overlap)."
FT                   /db_xref="InterPro:IPR017517"
FT                   /db_xref="UniProtKB/TrEMBL:O05777"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08389.1"
FT                   /translation="MTTPGRPLTTLDKSDVLAGLFAVWHSLDALLDGLLETDWQATSPL
FT                   PGWDVKAVVSHIIGTESFLLGIAAPEPDTDVSALAHVRNPIGVMNECWVRHLGTESGVG
FT                   LLERFRAVTSQRRKVLASLSDDEWNAPTTTPSGPDSYGRFMRIRIFDCWMHEQDIRAAV
FT                   QRPSSDDELGGPASPLVLDEIAATMGFVVGKLAKAPDGSRVLLELTGPLSRSIRVSVDG
FT                   RARVVDDFGGPAPTATIRLDGLQFTRLAGGRPMSPARSQDVELGGDKELAGHILERLNF
FT                   VI"
FT   CDS             complement(1638..2120)
FT                   /transl_table=11
FT                   /gene="smpB"
FT                   /locus_tag="Rv3100c"
FT                   /product="PROBABLE SSRA-BINDING PROTEIN SMPB"
FT                   /function="BINDS SPECIFICALLY TO THE SSRA RNA (TMRNA) AND
FT                   IS REQUIRED FOR STABLE ASSOCIATION OF SSRA WITH RIBOSOMES.
FT                   THOUGHT TO BE IMPLICATED IN THE SURVIVAL OF BACTERIUM
FT                   WITHIN MACROPHAGES."
FT                   /note="Rv3100c, (MTCY164.11c), len: 160 aa. Probable smpB,
FT                   small protein b related to several bacterial small protein
FT                   b homologs e.g. O32881|SSRP_MYCLE|ML0671|MLCB1779.19c from
FT                   Mycobacterium leprae (160 aa), FASTA scores: opt: 914, E():
FT                   1.1e-52, (84.9% identity in 159 aa overlap); Q9L1S9|SMPB
FT                   from Streptomyces coelicolor (159 aa), FASTA scores: opt:
FT                   568, E(): 3.3e-30, (55.15% identity in 145 aa overlap);
FT                   O32230|SSRP_BACSU from Bacillus subtilis (156 aa), FASTA
FT                   scores: opt: 511, E(): 1.7e-26, (47.05% identity in 153 aa
FT                   overlap); etc. BELONGS TO THE SSRP FAMILY."
FT                   /db_xref="GOA:P0A612"
FT                   /db_xref="HSSP:1J1H"
FT                   /db_xref="InterPro:IPR020081"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A612"
FT                   /protein_id="CAB08390.1"
FT                   /translation="MSKSSRGGRQIVASNRKARHNYSIIEVFEAGVALQGTEVKSLREG
FT                   QASLADSFATIDDGEVWLRNAHIPEYRHGSWTNHEPRRNRKLLLHRRQIDTLVGKIREG
FT                   NFALVPLSLYFAEGKVKVELALARGKQARDKRQDMARRDAQREVLRELGRRAKGMT"
FT   CDS             complement(2123..3016)
FT                   /transl_table=11
FT                   /gene="ftsX"
FT                   /locus_tag="Rv3101c"
FT                   /product="PUTATIVE CELL DIVISION PROTEIN FTSX (SEPTATION
FT                   COMPONENT-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC
FT                   TRANSPORTER)"
FT                   /function="INVOLVED IN GROWTH (PRINCIPALLY DURING LOG PHASE
FT                   CELLS). THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT                   SEPTATION COMPONENT ACROSS THE MEMBRANE. RESPONSIBLE FOR
FT                   THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. IS
FT                   CODED IN AN OPERON ESSENTIAL FOR CELL DIVISION."
FT                   /note="Rv3101c, (MTCY164.12c), len: 297 aa. Putative ftsX,
FT                   cell division protein, septation component transport
FT                   integral membrane protein ABC transporter (see citations
FT                   below), equivalent to O32882|FTSX_MYCLE|ML0670|MLCB1779.20c
FT                   CELL DIVISION PROTEIN from Mycobacterium leprae (297 aa),
FT                   FASTA scores: opt: 1597, E(): 9.2e-93, (80.8% identity in
FT                   297 aa overlap); and similar to others e.g.
FT                   Q9L1S7|SCE59.27c from Streptomyces coelicolor (305 aa),
FT                   FASTA scores: opt: 585, E(): 1.9e-29, (34.55% identity in
FT                   304 aa overlap); O34876|FTSX_BACSU from Bacillus subtilis
FT                   (296 aa), FASTA scores: opt: 318, E(): 9.1e-13, (24.65%
FT                   identity in 300 aa overlap); Q9K6X3|FTSX|BH3601 from
FT                   Bacillus halodurans (298 aa), FASTA scores: opt: 290, E():
FT                   5.2e-11, (22.75% identity in 299 aa overlap); etc. BELONGS
FT                   TO THE FTSX FAMILY."
FT                   /db_xref="GOA:P96293"
FT                   /db_xref="InterPro:IPR003838"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96293"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08391.1"
FT                   /translation="MRFGFLLNEVLTGFRRNVTMTIAMILTTAISVGLFGGGMLVVRLA
FT                   DSSRAIYLDRVESQVFLTEDVSANDSSCDTTACKALREKIETRSDVKAVRFLNRQQAYD
FT                   DAIRKFPQFKDVAGKDSFPASFIVKLENPEQHKDFDTAMKGQPGVLDVLNQKELIDRLF
FT                   AVLDGLSNAAFAVALVQAIGAILLIANMVQVAAYTRRTEIGIMRLVGASRWYTQLPFLV
FT                   EAMLAATMGVGIAVAGLMVVRALFLENALNQFYQANLIAKVDYADILFITPWLLLLGVA
FT                   MSGLTAYLTLRLYVRR"
FT   CDS             complement(3017..3706)
FT                   /transl_table=11
FT                   /gene="ftsE"
FT                   /locus_tag="Rv3102c"
FT                   /product="PUTATIVE CELL DIVISION ATP-BINDING PROTEIN FTSE
FT                   (SEPTATION COMPONENT-TRANSPORT ATP-BINDING PROTEIN ABC
FT                   TRANSPORTER)"
FT                   /function="INVOLVED IN GROWTH. THOUGHT TO BE INVOLVED IN
FT                   ACTIVE TRANSPORT OF SEPTATION COMPONENT ACROSS THE
FT                   MEMBRANE. RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT
FT                   SYSTEM. IS CODED IN AN OPERON ESSENTIAL FOR CELL DIVISION."
FT                   /note="Rv3102c, (MTCY164.13_2c), len: 229 aa. Putative
FT                   ftsE, cell division protein, septation component transport
FT                   ATP-binding protein ABC transporter (see citations below),
FT                   equivalent to O32883|FTSE|ML0669 CELL DIVISION ATP-BINDING
FT                   PROTEIN from Mycobacterium leprae (229 aa), FASTA scores:
FT                   opt: 1384, E(): 2.4e-74, (91.7% identity in 229 aa
FT                   overlap); and similar to Q9L1S6|FTSE from Streptomyces
FT                   coelicolor (229 aa), FASTA scores: opt: 914, E(): 8.7e-47,
FT                   (62.85% identity in 226 aa overlap); Q9A0S4|FTSE|SPY0644
FT                   from Streptococcus pyogenes (230 aa), FASTA scores: opt:
FT                   866, E(): 5.7e-44, (57.9% identity in 228 aa overlap);
FT                   Q9CGX0|FTSE from Lactococcus lactis (subsp. lactis)
FT                   (Streptococcus lactis) (230 aa), FASTA scores: opt: 792,
FT                   E(): 1.3e-39, (52.2% identity in 228 aa overlap); etc.
FT                   Other relatives from Mycobacterium tuberculosis include:
FT                   MTCY253.24; MTCY16B7.10; MTCY9C4.04c; MTCY50.01;
FT                   MTCY05A6.09c; MTCY04C12.31. Contains PS00017
FT                   ATP/GTP-binding site motif A (P-loop) and ABC transporters
FT                   family signature (PS00211). BELONG TO THE ATP-BINDING
FT                   TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)."
FT                   /db_xref="GOA:O05779"
FT                   /db_xref="HSSP:1L2T"
FT                   /db_xref="InterPro:IPR013505"
FT                   /db_xref="UniProtKB/TrEMBL:O05779"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08392.1"
FT                   /translation="MITLDHVTKQYKSSARPALDDINVKIDKGEFVFLIGPSGSGKSTF
FT                   MRLLLAAETPTSGDVRVSKFHVNKLRGRHVPKLRQVIGCVFQDFRLLQQKTVYDNVAFA
FT                   LEVIGKRTDAINRVVPEVLETVGLSGKANRLPDELSGGEQQRVAIARAFVNRPLVLLAD
FT                   EPTGNLDPETSRDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVVELSLGRLVRDEQR
FT                   GVYGMDR"
FT   misc_feature    complement(3248..3292)
FT                   /note="PS00211 ABC transporters family signature"
FT   misc_feature    complement(3578..3601)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(3750..4187)
FT                   /transl_table=11
FT                   /locus_tag="Rv3103c"
FT                   /product="HYPOTHETICAL PROLINE-RICH PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3103c, (MTCY164.13c), len: 145 aa. Hypothetical
FT                   unknown pro-rich protein, with some similarity to
FT                   Proline-rich proteins e.g. Q39789 PROLINE-RICH CELL WALL
FT                   PROTEIN from Gossypium hirsutum (Upland cotton) (214 aa),
FT                   FASTA scores: opt: 267, E(): 0.00014, (40% identity in 110
FT                   aa overlap). Equivalent to AAK47525 from M. mycobacterium
FT                   strain CDC1551 (158 aa) but shorter 13 aa."
FT                   /db_xref="InterPro:IPR001412"
FT                   /db_xref="UniProtKB/TrEMBL:O05780"
FT                   /protein_id="CAB08393.1"
FT                   /translation="MKLSNQKRHWPGYLFGRIRTSTLVLIAAFLAVWWIYETYRPQAPG
FT                   PGDSPPTQVVPPGFVPDPDYTWVPRTRVQPPTVKATPTTTSSTPPVSPPETTTDSAVPP
FT                   PFELPPPFGPGTTTPTPPAPLPQPGPGPTAGTYPKSEPPTR"
FT   CDS             complement(4189..5115)
FT                   /transl_table=11
FT                   /locus_tag="Rv3104c"
FT                   /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3104c, (MTCY164.14c), len: 308 aa. Possible
FT                   conserved transmembrane protein, with some similarity to
FT                   hypthetical proteins e.g. Q9L1X9|SC8E4A.26 PUTATIVE
FT                   MEMBRANE PROTEIN from Streptomyces coelicolor (408 aa),
FT                   FASTA scores: opt: 514, E(): 4.3e-25, (35.2% identity in
FT                   287 aa overlap); Q9XA89|CF43A.26c HYPOTHETICAL 36.1 KDA
FT                   PROTEIN from Streptomyces coelicolor (333 aa), FASTA
FT                   scores: opt: 482, E(): 3.7e-23, (34.9% identity in 301 aa
FT                   overlap); Q55987|SLR0765 HYPOTHETICAL 68.9 KDA PROTEIN from
FT                   Synechocystis sp. strain PCC 6803 (617 aa), FASTA scores:
FT                   opt: 429, E(): 1.3e-19, (30.6% identity in 278 aa overlap);
FT                   etc."
FT                   /db_xref="GOA:O05781"
FT                   /db_xref="InterPro:IPR006685"
FT                   /db_xref="UniProtKB/TrEMBL:O05781"
FT                   /protein_id="CAB08394.1"
FT                   /translation="MTTSGTVLATSIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVLA
FT                   ARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEVID
FT                   VLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGSPEN
FT                   AAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVN
FT                   EVLHQECEHARHDSLLGELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRV
FT                   LVIRALTRAGIVTAADARAAVAESPEQ"
FT   CDS             complement(5105..6241)
FT                   /transl_table=11
FT                   /gene="prfB"
FT                   /locus_tag="Rv3105c"
FT                   /product="PROBABLE PEPTIDE CHAIN RELEASE FACTOR 2 PRFB
FT                   (RF-2)"
FT                   /function="PEPTIDE CHAIN RELEASE FACTOR 2 DIRECTS THE
FT                   TERMINATION OF TRANSLATION IN RESPONSE TO THE PEPTIDE CHAIN
FT                   TERMINATION CODONS UGA AND UAA."
FT                   /note="Rv3105c, (MTCY164.15c), len: 378 aa. Probable prfB,
FT                   peptide chain release factor 2, equivalent to
FT                   O32885|RF2_MYCLE|ML0667|MLCB1779.24c from Mycobacterium
FT                   leprae, FASTA scores: opt: 2197, E(): 1.8e-126, (90.05%
FT                   identity in 372 aa overlap); and also similar to other
FT                   peptide chain release factors e.g. Q9L1S3|PRFB from
FT                   Streptomyces coelicolor (368 aa), FASTA scores: opt: 1674,
FT                   E(): 1.2e-94, (69.3% identity in 365 aa overlap);
FT                   O67695|RF2_AQUAE|PRFB|AQ_1840 from Aquifex aeolicus (373
FT                   aa), FASTA scores: opt: 1082, E(): 1.3e-58, (44.45%
FT                   identity in 369 aa overlap); P28367|RF2_BACSU from B.
FT                   subtilis (366 aa), FASTA scores: opt: 1030, E(): 1.9e-55,
FT                   (44.0% identity in 359 aa overlap); etc. Also related to
FT                   Q10605|MTCY373.19|RF1_MYCTU|Rv1299|MT1338 peptide chain
FT                   release factor 1 (rf-1) (357 aa), FASTA scores: opt: 646,
FT                   E(): 1.1e-34, (38.6% identity in 350 aa overlap). Contains
FT                   prokaryotic-type class I peptide chain release factors
FT                   signature (PS00745). BELONGS TO THE PROKARYOTIC AND
FT                   MITOCHONDRIAL RELEASE FACTORS FAMILY. TBparse score is
FT                   0.888."
FT                   /db_xref="GOA:P66026"
FT                   /db_xref="HSSP:1GQE"
FT                   /db_xref="InterPro:IPR004374"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66026"
FT                   /protein_id="CAB08395.1"
FT                   /translation="MPVTLAAVDPDRQADIAALDCTLTTVERVLDVEGLRSRIEKLEHE
FT                   ASDPHLWDDQTRAQRVTSELSHTQGELRRVEELRRRLDDLPVLYELAAEEAGAAAADAV
FT                   AEADAELKSLRADIEATEVRTLLSGEYDEREALVTIRSGAGGVDAADWAEMLMRMYIRW
FT                   AEQHKYPVEVFDTSYAEEAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQSRRQ
FT                   TSFAEVEVLPVVETTDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPSGIVVT
FT                   CQNEKSQLQNKIAAMRVLQAKLLERKRLEERAELDALKADGGSSWGNQMRSYVLHPYQM
FT                   VKDLRTEYEVGNPAAVLDGDLDGFLEAGIRWRNRRNDD"
FT   misc_feature    complement(5435..5485)
FT                   /note="PS00745 Prokaryotic-type class I peptide chain
FT                   release factors signature"
FT   CDS             6344..7714
FT                   /transl_table=11
FT                   /gene="fprA"
FT                   /locus_tag="Rv3106"
FT                   /product="NADPH:ADRENODOXIN OXIDOREDUCTASE FPRA
FT                   (NADPH-FERREDOXIN REDUCTASE)"
FT                   /function="GENERATES OXIDIZED FERREDOXIN FROM FERREDOXIN
FT                   [CATALYTIC ACTIVITY: REDUCED FERREDOXIN + NADP(+) =
FT                   OXIDIZED FERREDOXIN + NADPH]."
FT                   /EC_number="1.18.1.2"
FT                   /note="Rv3106, (MTCY164.16), len: 456 aa. fprA,
FT                   NADPH:adrenodoxin oxidoreductase (NADPH-ferredoxin
FT                   reductase) (EC 1.18.1.2) (see citations below), equivalent
FT                   to O32886|MLCB1779.25|FPRA|ML0666 from Mycobacterium leprae
FT                   (456 aa), FASTA scores: opt: 2505, E(): 1.2e-142, (81,05%
FT                   identity in 459 aa overlap); also similar to other
FT                   NADPH:adrenodoxin oxidoreductases e.g. Q9RX19|DR0496 from
FT                   Deinococcus radiodurans (479 aa), FASTA scores: opt: 1331,
FT                   E(): 2.6e-72, (48.9% identity in 454 aa overlap);
FT                   Q9RK35|SCF15.02 from Streptomyces coelicolor (454 aa),
FT                   FASTA scores: opt: 1102, E(): 1.3e-58, (41.35% identity in
FT                   462 aa overlap); P82861 from Salvelinus fontinalis (Brook
FT                   trout) (498 aa), FASTA scores: opt: 827, E(): 4e-42, (41.3%
FT                   identity in 460 aa overlap); Q9V3T9|ADRO_DROME from
FT                   Drosophila melanogaster (Fruit fly) (466 aa), FASTA scores:
FT                   opt: 790, E(): 6.3e-40, (39.45% identity in 459 aa
FT                   overlap); etc. Also similar to
FT                   Q10547|FPRB|Rv0886|MT0909|MTCY31.14 from Mycobacterium
FT                   tuberculosis strain H37Rv (575 aa), FASTA scores: opt: 894,
FT                   E(): 4.4e-46, (42.05% identity in 459 aa overlap)."
FT                   /db_xref="GOA:O05783"
FT                   /db_xref="InterPro:IPR013027"
FT                   /db_xref="PDB:1LQT"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05783"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08363.1"
FT                   /translation="MRPYYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPTP
FT                   WGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELSERYDAVIYAV
FT                   GAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPDLSGARAVVIGNGNVALDVA
FT                   RILLTDPDVLARTDIADHALESLRPRGIQEVVIVGRRGPLQAAFTTLELRELADLDGVD
FT                   VVIDPAELDGITDEDAAAVGKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIKGK
FT                   RKVERIVLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQSGT
FT                   IPNVGGRINGSPNEYVVGWIKRGPTGVIGTNKKDAQDTVDTLIKNLGNAKEGAECKSFP
FT                   EDHADQVADWLAARQPKLVTSAHWQVIDAFERAAGEPHGRPRVKLASLAELLRIGLG"
FT   CDS             complement(7715..9298)
FT                   /transl_table=11
FT                   /gene="agpS"
FT                   /locus_tag="Rv3107c"
FT                   /product="POSSIBLE ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE
FT                   AGPS (ALKYL-DHAP SYNTHASE) (ALKYLGLYCERONE-PHOSPHATE
FT                   SYNTHASE)"
FT                   /function="INVOLVED IN ETHER LIPID BIOSYNTHESIS [CATALYTIC
FT                   ACTIVITY: 1-ACYL-GLYCERONE 3-PHOSPHATE + A LONG-CHAIN
FT                   ALCOHOL = 1-ALKYL-GLYCERONE 3-PHOSPHATE + A LONG-CHAIN ACID
FT                   ANION]."
FT                   /EC_number="2.5.1.26"
FT                   /note="Rv3107c, (MTCY164.17c), len: 527 aa. Possible agpS,
FT                   alkyl-dihydroxyacetonephosphate synthase (EC 2.5.1.26),
FT                   similar to others and some various enzymes e.g.
FT                   AAK46595|MT2311 PUTATIVE ALKYL-DIHYDROXYACETONEPHOSPHATE
FT                   SYNTHASE from Mycobacterium tuberculosis strain CDC1551
FT                   (529 aa), FASTA scores: opt: 1052, E(): 2.1e-58, (37.1%
FT                   identity in 542 aa overlap); Q9RJ97|SCF91.28c PUTATIVE
FT                   FLAVOPROTEIN from Streptomyces coelicolor (530 aa), FASTA
FT                   scores: opt: 972, E(): 2.2e-53, (36.2% identity in 544 aa
FT                   overlap); O96759|ADAS_DICDI ALKYLDIHYDROXYACETONEPHOSPHATE
FT                   SYNTHASE (EC 2.5.1.26) from Dictyostelium discoideum (Slime
FT                   mold) (611 aa), FASTA scores: opt: 617, E(): 4.5e-31,
FT                   (33.95% identity in 480 aa overlap); O97157|ADAS_TRYBB
FT                   ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE from Trypanosoma
FT                   brucei (613 aa), FASTA scores: opt: 567, E(): 6.2e-28,
FT                   (29.15% identity in 521 aa overlap); etc. Also similar to
FT                   O53525|Rv2251|MTV022.01 HYPOTHETICAL 49.8 KDA PROTEIN from
FT                   Mycobacterium tuberculosis strain H37Rv (475 aa), FASTA
FT                   scores: opt: 1019, E(): 2.3e-56, (38.6% identity in 487 aa
FT                   overlap). BELONGS TO THE FAD-BINDING
FT                   OXIDOREDUCTASE/TRANSFERASE FAMILY 4. COFACTOR: FAD (BY
FT                   SIMILARITY)."
FT                   /db_xref="GOA:O05784"
FT                   /db_xref="InterPro:IPR016167"
FT                   /db_xref="UniProtKB/TrEMBL:O05784"
FT                   /protein_id="CAB08364.1"
FT                   /translation="MRSWWGWGTVEDALSDQETQALQSRVAALVSGHDLSDHPPPDLTA
FT                   LGLAAPRVSPPASLAALCSSDLVDRAGHARGKAYRDIARNLQGQLDHLPDLIARPRSEQ
FT                   DVIDVLDWCAREGIAVIPYGGGSSVVGGVEPRFDEPVVTVDVTAMSAVLEIDRVSRAAR
FT                   IQAGAFGPSIEHQLRPHDLTLRHFPQSFGFSTLGGWLATRSGGHFATLYTHIDDLTESL
FT                   RIVTPVGISESRRLPGSGAGPSPDRLFLGSEGTLGIITEAWMRLQHRPRWQVTVSVVFD
FT                   DWAAAVAATRTIAQAGLYPANCRLLDPAEALLNAGTSVGGGLLVLAFESADHPIDPWLH
FT                   RAVAITAEHGGTVTAQRSRGTTSDATEHNAAANWRSAFLRMPYQRDALVRRGVIAETFE
FT                   TACTWDGFDTLHAAVTDAARTAIWKVCGTGVVTCRFTHVYPDGPAPYYGIYAGGRWGSL
FT                   DAQWDEIKAAVSEAISASGGTITHHHAVGRDHRAWYDRQRPDPFAAALRAAKSALDPAG
FT                   ILNPGVLLGR"
FT   CDS             9397..9837
FT                   /transl_table=11
FT                   /locus_tag="Rv3108"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3108, (MTCY164.18), len: 146 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O05785"
FT                   /protein_id="CAB08365.1"
FT                   /translation="MTPNAASTGDSAKNTITGCCLITARALVARTRSISLPGMPFRMPA
FT                   DYHNASSDEPTNRHPWPAPARCCRHEWRTMRRTNACDRRRFGLSLTIHEDACRIISVVP
FT                   VVLEVRRAEPAHPATPYPEPLARCSRSPGLNESSHMSGRIPP"
FT   CDS             9986..11065
FT                   /transl_table=11
FT                   /gene="moaA1"
FT                   /locus_tag="Rv3109"
FT                   /standard_name="moaA"
FT                   /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN
FT                   A MOAA1"
FT                   /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS;
FT                   INVOLVED IN THE BIOSYNTHESIS OF MOLYBDOPTERIN PRECURSOR Z
FT                   FROM GUANOSINE."
FT                   /note="Rv3109, (MTCY164.19), len: 359 aa. Probable moaA1,
FT                   molybdenum cofactor biosynthesis protein, highly similar to
FT                   others e.g. P39757|MOAA_BACSU|NARA|NARAB from Bacillus
FT                   subtilis (341 aa), FASTA scores: opt: 810, E(): 6.2e-44,
FT                   (39.75% identity in 327 aa overlap);
FT                   O67929|MOAA_AQUAE|AQ_2183 from Aquifex aeolicus (320 aa),
FT                   FASTA scores: opt: 794, E(): 6e-43, (40.55% identity in 323
FT                   aa overlap); Q9ZIM6|MOAA_STACA from Staphylococcus carnosus
FT                   (340 aa), FASTA scores: opt: 783, E(): 3.2e-42, (38.65%
FT                   identity in 326 aa overlap); etc. Also highly similar to
FT                   O53143|MOAA3|MOA3_MYCTU|MT3427 MOLYBDENUM COFACTOR
FT                   BIOSYNTHESIS PROTEIN A 3 from Mycobacterium tuberculosis
FT                   strain F4 (378 aa), FASTA scores: opt: 1762, E(): 4.7e-104,
FT                   (74.3% identity in 350 aa overlap); and similar to
FT                   O53881|MOA2_MYCTU|MOAA2|Rv0869c|MT0892|MTV043.62 MOLYBDENUM
FT                   COFACTOR BIOSYNTHESIS PROTEIN A 2 from Mycobacterium
FT                   tuberculosis strain H37Rv (360 aa), FASTA scores: opt: 657,
FT                   E(): 3e-34, (36.55% identity in 309 aa overlap). BELONGS TO
FT                   THE MOAA / NIFB / PQQE FAMILY. Note that previously known
FT                   as moaA."
FT                   /db_xref="GOA:O05786"
FT                   /db_xref="InterPro:IPR007197"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05786"
FT                   /protein_id="CAE55548.1"
FT                   /translation="MSTPTLPDMVAPSPRVRVKDRCRRMMGDLRLSVIDQCNLRCRYCM
FT                   PEEHYTWLPRQDLLSVKEISAIVDVFLSVGVSKVRITGGEPLIRPDLPEIVRTLSAKVG
FT                   EDSGLRDLAITTNGVLLADRVDGLKAAGMKRITVSLDTLQPERFKAISQRNSHDKVIAG
FT                   IKAVAAAGFTDTKIDTTVMRGANHDELADLIEFARTVNAEVRFIEYMDVGGATHWAWEK
FT                   VFTKANMLESLEKRYGRIEPLPKHDTAPANRYALPDGTTFGIIASTTEPFCATCDRSRL
FT                   TADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTGWRRRTDRGAEQRLAQRERGVF
FT                   LPLSTLKADPHLEMHTRGG"
FT   CDS             11116..11511
FT                   /transl_table=11
FT                   /gene="moaB1"
FT                   /locus_tag="Rv3110"
FT                   /standard_name="moaB"
FT                   /product="PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE
FT                   MOAB1 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE)
FT                   (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE
FT                   HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN
FT                   CARBINOLAMINE DEHYDRATASE) (PCD)"
FT                   /function="THOUGHT TO BE INVOLVED IN MOLYBDOPTERIN
FT                   BIOSYNTHESIS. CATALYZES THE DEHYDRATATION OF
FT                   4A-HYDROXYTETRAHYDROPTERINS [CATALYTIC ACTIVITY:
FT                   (6R)-6-(L-ERYTHRO-1,2-DIHYDROXYPROPYL)-5,6,7,8-TETRAHYDRO
FT                   -4 A-HYDROXYPTERIN = (6R)-6-(L-ERYTHRO-1,2-
FT                   DIHYDROXYPROPYL)-7,8-DIHYDRO-6H-PTERIN + H(2)O]."
FT                   /EC_number="4.2.1.96"
FT                   /note="Rv3110, (MTCY164.20), len: 131 aa. Probable moaB1,
FT                   pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96),
FT                   similar to others e.g. P73790|SSL2296 from Synechocystis
FT                   sp. strain PCC 6803 (96 aa), FASTA scores: opt: 195, E():
FT                   6.2e-07, (35.4% identity in 96 aa overlap);
FT                   Q9PAB4|PHS_XYLFA|XF2604 from Xylella fastidiosa (116 aa),
FT                   FASTA scores: opt: 187, E(): 2.6e-06, (36.25% identity in
FT                   102 aa overlap); AAK42360|Q97WM6|PHS_SULSO|SSO2187 from
FT                   Sulfolobus solfataricus (114 aa), FASTA scores: opt: 177,
FT                   E(): 1.3e-05, (34.6% identity in 78 aa overlap); etc. Also
FT                   highly similar to AAK47768|MT3426
FT                   PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium
FT                   tuberculosis CDC1551 (124 aa), FASTA scores: opt: 383, E():
FT                   7.7e-20, (50.0% identity in 110 aa overlap). BELONGS TO THE
FT                   PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Note that
FT                   previously known as moaB."
FT                   /db_xref="GOA:Q6MX13"
FT                   /db_xref="InterPro:IPR001533"
FT                   /db_xref="UniProtKB/TrEMBL:Q6MX13"
FT                   /protein_id="CAE55549.1"
FT                   /translation="MTVSTPEQHEQRASHDASEGKHNVCQGRLAALADAAVSEKLGALP
FT                   GWQLLDMRLSRAFQCTNFDQSIDFMNRVASIANDINHHPDIAVLDKRSVRVTAWTRKLG
FT                   YLTDIDFDLAASVEAMYATEFADRPAR"
FT   CDS             11508..12020
FT                   /transl_table=11
FT                   /gene="moaC1"
FT                   /locus_tag="Rv3111"
FT                   /standard_name="moaC"
FT                   /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN
FT                   C MOAC1"
FT                   /function="INVOLVED IN THE BIOSYNTHESIS OF MOLYBDOPTERIN."
FT                   /note="Rv3111, (MTCY164.21), len: 170 aa. Probable moaC1,
FT                   molybdopterin cofactor biosynthesis protein, highly similar
FT                   to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas
FT                   aeruginosa (160 aa), FASTA scores: opt: 576, E(): 2.2e-29,
FT                   (62.1% identity in 153 aa overlap); Q9ZFA6|MOAC from
FT                   Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (159
FT                   aa), FASTA scores: opt: 541, E(): 3.4e-27, (59.85% identity
FT                   in 157 aa overlap); BAB48171|MLR0616 from Rhizobium loti
FT                   (Mesorhizobium loti) (160 aa), FASTA scores: opt: 531, E():
FT                   1.5e-26, (58.75% identity in 160 aa overlap);
FT                   P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain
FT                   K12 (160 aa), FASTA scores: opt: 527, E(): 2.6e-26, (58.5%
FT                   identity in 159 aa overlap); etc. Also highly similar to
FT                   O53376|MOAC3|Rv3324c|MTV016.24c PUTATIVE MOLYBDENUM
FT                   COFACTOR BIOSYNTHESIS PROTEIN C 3 from Mycobacterium
FT                   tuberculosis (177 aa), FASTA scores: opt: 738, E():
FT                   1.7e-39, (71.5% identity in 165 aa overlap);
FT                   AAK47767|MT3425 MOLYBDOPTERIN COFACTOR BIOSYNTHESIS PROTEIN
FT                   C from Mycobacterium tuberculosis strain CDC1551 (184 aa),
FT                   FASTA scores: opt: 734, E(): 3.1e-39, (71.8% identity in
FT                   163 aa overlap); and Rv0864|MOAC2|MTV043.57 PUTATIVE
FT                   MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 2 (167 aa). Note
FT                   that previously known as moaC."
FT                   /db_xref="GOA:P0A5K4"
FT                   /db_xref="HSSP:1EKR"
FT                   /db_xref="InterPro:IPR002820"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5K4"
FT                   /protein_id="CAE55550.1"
FT                   /translation="MIDHALALTHIDERGAARMVDVSEKPVTLRVAKASGLVIMKPSTL
FT                   RMISDGAAAKGDVMAAARIAGIAAAKRTGDLIPLCHPLGLDAVSVTITPCEPDRVKILA
FT                   TTTTLGRTGVEMEALTAVSVAALTIYDMCKAVDRAMEISQIVLQEKSGGRSGVYRRSAS
FT                   DLACQSR"
FT   CDS             12037..12288
FT                   /transl_table=11
FT                   /gene="moaD1"
FT                   /locus_tag="Rv3112"
FT                   /standard_name="moaD"
FT                   /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN
FT                   D MOAD1 (MOLYBDOPTERIN CONVERTING FACTOR SMALL SUBUNIT)
FT                   (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT 1)"
FT                   /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS."
FT                   /note="Rv3112, (MTCY164.22), len: 83 aa. Probable moaD1,
FT                   molybdenum cofactor biosynthesis protein (molybdopterin
FT                   converting factor (subunit 1)), similar to others e.g.
FT                   Q9HJF0|TA1019 from Thermoplasma acidophilum (85 aa), FASTA
FT                   scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa
FT                   overlap); BAB59710|TVG0556526 from Thermoplasma volcanium
FT                   (90 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7%
FT                   identity in 82 aa overlap);
FT                   P30748|MOAD_ECOLI|CHLA4|CHLM|B0784 from Escherichia coli
FT                   strain K12 (81 aa), FASTA scores: opt: 116, E(): 0.11,
FT                   (36.9% identity in 84 aa overlap); etc. N-terminus also
FT                   highly similar to to O53375|GPHA|Rv3323c|MTV016.23c
FT                   MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis
FT                   (221 aa), FASTA scores: opt: 333, E(): 2e-16, (65.05%
FT                   identity in 83 aa overlap); and some similarity with
FT                   Rv0868c|MTV043.61c|MOAD2 PUTATIVE MOLYBDENUM COFACTOR
FT                   BIOSYNTHESIS PROTEIN D 2 (92 aa). Note that previously
FT                   known as moaD."
FT                   /db_xref="GOA:Q7D640"
FT                   /db_xref="HSSP:1JWA"
FT                   /db_xref="InterPro:IPR012675"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D640"
FT                   /protein_id="CAE55551.1"
FT                   /translation="MIKVNVLYFGAVREACDETPREEVEVQNGTDVGNLVDQLQQKYPR
FT                   LRDHCQRVQMAVNQFIAPLSTVLGDGDEVAFIPQVAGG"
FT   CDS             12411..13079
FT                   /transl_table=11
FT                   /locus_tag="Rv3113"
FT                   /product="POSSIBLE PHOSPHATASE"
FT                   /function="UNKNOWN"
FT                   /EC_number="3.1.3.-"
FT                   /note="Rv3113, (MTCY164.23), len: 222 aa. Possible
FT                   phosphatase (EC 3.1.3.-), with weak similarity to other
FT                   phosphatases e.g. Q9KYY0|SCE33.02c from Streptomyces
FT                   coelicolor (223 aa), FASTA scores: opt: 368, E(): 1.2e-16,
FT                   (32.9% identity in 222 aa overlap); and
FT                   Q55039|GPH_SYNP7|CBBZ PHOSPHOGLYCOLATE PHOSPHATASE from
FT                   Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
FT                   (212 aa), FASTA scores: opt: 176, E(): 0.00025, (24.7%
FT                   identity in 182 aa overlap)."
FT                   /db_xref="GOA:O05790"
FT                   /db_xref="InterPro:IPR006439"
FT                   /db_xref="UniProtKB/TrEMBL:O05790"
FT                   /protein_id="CAB08370.1"
FT                   /translation="MTSRDGFTIVWDWNGTLCDDRTILLDAVGQTLVNEGFEPLSQQQL
FT                   IQRFARPLRTFFENACGRDLLTSEWERVQSTFRRIYRSREAEVTLVEDAYDVLAQGNRS
FT                   AAGQFLLSLAPHDELMHFVQKYGIAKWFNGIRGRTRPDQEKPMMLAELIMQRSLNPTRV
FT                   VHIGDSLEDAAAASAVGAISVLVTGASLQPPDRVMLKQLQPFVASSLKQALQYAGGDGD
FT                   "
FT   CDS             13096..13626
FT                   /transl_table=11
FT                   /locus_tag="Rv3114"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3114, (MTCY164.24), len: 176 aa. Conserved
FT                   hypothetical protein, with some similarity to Q9F9W7
FT                   CYTOSINE DEAMINASE from Bifidobacterium longum (143 aa),
FT                   FASTA scores: opt: 207, E(): 2.2e-07, (37.05% identity in
FT                   108 aa overlap); and Q9RV23|DR1207 CELL CYCLE PROTEIN MESJ,
FT                   PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN from
FT                   Deinococcus radiodurans (600 aa), FASTA scores: opt: 212,
FT                   E(): 3.5e-07, (33.35% identity in 177 aa overlap).
FT                   Equivalent to AAK47536|MT3196 CYTIDINE AND DEOXYCYTIDYLATE
FT                   DEAMINASE FAMILY PROTEIN from Mycobacterium tuberculosis
FT                   strain CDC1551 (187 aa) but shorter 11 aa."
FT                   /db_xref="GOA:O05791"
FT                   /db_xref="InterPro:IPR002125"
FT                   /db_xref="UniProtKB/TrEMBL:O05791"
FT                   /protein_id="CAB08371.1"
FT                   /translation="MVAARLPFGWSADSGVTADIIEAAMELAIDTARHATAPFGAALLD
FT                   VTTLRAFSGGNTYFESGDRFAHAETNVLRAAMSTLPELSNHVLISTAEPCPMCAAASVL
FT                   SGVRAIIFGTSIETLIQCGWFQIRISASDVVAASTRPTRPSVYSGFLSHKTDLLYRNSE
FT                   NRRAMNPWTDPSH"
FT   repeat_region   13736..13750
FT                   /note="15 bp inverted repeat at left end of IS1081:
FT                   TCGCGTGATCCTTCG"
FT   repeat_region   13736..15059
FT                   /mobile_element="insertion sequence:IS1081-6"
FT                   /note="IS1081-6, len: 1324 bp. Insertion sequence IS1081."
FT   CDS             13788..15035
FT                   /transl_table=11
FT                   /locus_tag="Rv3115"
FT                   /product="PROBABLE TRANSPOSASE"
FT                   /function="INVOLVED IN THE TRANSPOSITION IN THE INSERTION
FT                   SEQUENCE IS1081."
FT                   /note="Rv3115, (MTCY164.25), len: 415 aa. Probable IS1081
FT                   transposase, similar to others. Has transposases, mutator
FT                   family, signature (PS01007). Other copies are MTCY10G2.02c,
FT                   MTCY441.35, MTCY77.03c. TBparse score is 0.894."
FT                   /db_xref="GOA:P96354"
FT                   /db_xref="InterPro:IPR001207"
FT                   /db_xref="UniProtKB/TrEMBL:P96354"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08372.1"
FT                   /translation="MTSSHLIDAEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALC
FT                   GAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALT
FT                   SVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTF
FT                   LAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVAR
FT                   GLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSI
FT                   YDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIWSNNPQE
FT                   RLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTST
FT                   EEPAKQQTTNTPALTT"
FT   misc_feature    14484..14558
FT                   /note="PS01007 Transposases, Mutator family, signature"
FT   repeat_region   complement(15045..15059)
FT                   /note="15 bp inverted repeat at right end of IS1081:
FT                   TCGCGTGATCCTTCG"
FT   CDS             15113..16282
FT                   /transl_table=11
FT                   /gene="moeB2"
FT                   /locus_tag="Rv3116"
FT                   /standard_name="moeB"
FT                   /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN
FT                   MOEB2 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE
FT                   SULPHURYLASE)"
FT                   /function="POSSIBLY INVOLVED IN MOLYBDOPTERIN METABOLISM
FT                   (SYNTHESIS)."
FT                   /note="Rv3116, (MTCY164.26), len: 389 aa. Probable moeB2,
FT                   molybdopterin cofactor biosynthesis protein, equivalent to
FT                   Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN
FT                   MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395
FT                   aa), FASTA scores: opt: 1433, E(): 8e-80, (57.8% identity
FT                   in 384 aa overlap). Very similar to members of the
FT                   HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE
FT                   SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA
FT                   scores: opt: 1562, E(): 1.1e-87, (58.15% identity in 380 aa
FT                   overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE
FT                   SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas
FT                   perfectomarina) (391 aa), FASTA scores: opt: 1311, E():
FT                   2.1e-72, (52.4% identity in 395 aa overlap);
FT                   O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus
FT                   sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA
FT                   scores: opt: 1238, E(): 5.7e-68, (51.4% identity in 393 aa
FT                   overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS
FT                   MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392
FT                   aa), FASTA scores: opt: 1212, E(): 2.2e-66, (46.5% identity
FT                   in 398 aa overlap); etc. Also highly similar to
FT                   O05860|MTCY07D11.20|MOEB1|Rv3206c PUTATIVE MOLYBDENUM
FT                   COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium
FT                   tuberculosis strain H37Rv (392 aa), FASTA scores: opt:
FT                   1445, E(): 1.5e-80, (56.25% identity in 400 aa overlap).
FT                   BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously
FT                   known as moeB."
FT                   /db_xref="GOA:Q7D637"
FT                   /db_xref="HSSP:1JW9"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D637"
FT                   /protein_id="CAE55552.1"
FT                   /translation="MTEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARVL
FT                   CIGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPKVESAAEAV
FT                   AEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYVWGS
FT                   IYRFNGQTSVFWPGRGPCYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTEVLKL
FT                   LTGVGTPLVGRLLMYEALDATYHQIRIAKNPDCAICGDAPTITELVDDSVSCASTQSVD
FT                   PELVISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGLAQLPLD
FT                   KEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSSLLVY"
FT   CDS             16311..17144
FT                   /transl_table=11
FT                   /gene="cysA3"
FT                   /locus_tag="Rv3117"
FT                   /standard_name="sseC3"
FT                   /product="PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA3
FT                   (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE
FT                   TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)"
FT                   /function="MAY BE A SULFOTRANSFERASE INVOLVED IN THE
FT                   FORMATION OF THIOSULFATE [CATALYTIC ACTIVITY: THIOSULFATE +
FT                   CYANIDE = SULFITE + THIOCYANATE]."
FT                   /EC_number="2.8.1.1"
FT                   /note="Rv3117, (MTCY164.27, MT3199, O05793), len: 277 aa.
FT                   Probable cysA3 (alternate gene name: sseC3), thiosulfate
FT                   sulfurtransferase (EC 2.8.1.1) (see Wooff et al., 2002),
FT                   equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE
FT                   SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae
FT                   (277 aa). Also highly similar to other putative thiosulfate
FT                   sulfurtransferases e.g. P16385|THTR_SACER|CYSA from
FT                   Saccharopolyspora erythraea (Streptomyces erythraeus) (281
FT                   aa), FASTA scores: opt: 1442, E(): 1.7e-84, (75.55%
FT                   identity in 274 aa overlap); Q9RXT9DR0217|DR0217 from
FT                   Deinococcus radiodurans (286 aa), FASTA scores: opt: 1046,
FT                   E(): 2.6e-59, (53.8% identity in 275 aa overlap);
FT                   Q9HMT7|TSSA|VNG2393G from Halobacterium sp. strain NRC-1
FT                   (293 aa), FASTA scores: opt: 1030, E(): 2.7e-58, (56.1%
FT                   identity in 278 aa overlap); Q9Y8N8|APE2595 from Aeropyrum
FT                   pernix (218 aa), FASTA scores: opt: 808, E(): 2.7e-44,
FT                   (53.5% identity in 215 aa overlap); etc. Identical second
FT                   copy present as
FT                   Rv0815c|AL022004|MTV043.07c|MT0837|O05793|cysA2 (277 aa)
FT                   (100.0% identity in 277 aa overlap). Also shows some
FT                   similarity to
FT                   P96888|THT2_MYCTU|SSEA|Rv3283|MT3382|MTCY71.23 PUTATIVE
FT                   THIOSULFATE SULFURTRANSFERASE from Mycobacterium
FT                   tuberculosis (297 aa), FASTA scores: opt: 955, E():
FT                   1.6e-53, (50.2% identity in 271 aa overlap); and
FT                   Q59570|THT3_MYCTU|SSEB|Rv2291|MT2348|MTCY339.19c PUTATIVE
FT                   THIOSULFATE SULFURTRANSFERASE from Mycobacterium
FT                   tuberculosis (284 aa), FASTA scores: E(): 1.4e-14, (26.7%
FT                   identity in 292 aa overlap). Contains rhodanese active site
FT                   and C-terminal signatures (PS00380, PS00683). BELONGS TO
FT                   THE RHODANESE FAMILY. TBparse score is 0.901."
FT                   /db_xref="GOA:O05793"
FT                   /db_xref="InterPro:IPR001307"
FT                   /db_xref="PDB:3HWI"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05793"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08374.1"
FT                   /translation="MARCDVLVSADWAESNLHAPKVVFVEVDEDTSAYDRDHIAGAIKL
FT                   DWRTDLQDPVKRDFVDAQQFSKLLSERGIANEDTVILYGGNNNWFAAYAYWYFKLYGHE
FT                   KVKLLDGGRKKWELDGRPLSSDPVSRPVTSYTASPPDNTIRAFRDEVLAAINVKNLIDV
FT                   RSPDEFSGKILAPAHLPQEQSQRPGHIPGAINVPWSRAANEDGTFKSDEELAKLYADAG
FT                   LDNSKETIAYCRIGERSSHTWFVLRELLGHQNVKNYDGSWTEYGSLVGAPIELGS"
FT   misc_feature    16935..17027
FT                   /note="PS00380 Rhodanese active site"
FT   misc_feature    17082..17105
FT                   /note="PS00683 Rhodanese C-terminal signature"
FT   CDS             17146..17448
FT                   /transl_table=11
FT                   /gene="sseC1"
FT                   /locus_tag="Rv3118"
FT                   /standard_name="sseC"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN SSEC1"
FT                   /function="THOUGHT TO BE INVOLVED IN SULPHUR METABOLISM."
FT                   /note="Rv3118, (MTCY164.28, O05794), len: 100 aa. sseC1,
FT                   conserved hypothetical protein, equivalent to Q9CBC7|ML2199
FT                   HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa),
FT                   FASTA scores: opt: 545, E(): 3.1e-30, (84.0% identity in 10
FT                   aa overlap). Also similar to hypothetical proteins e.g.
FT                   Q50035 from Saccharopolyspora erythraea (Streptomyces
FT                   erythraeus) (101 aa), FASTA scores: opt: 345, E(): 9.7e-17,
FT                   (57.15% identity in 98 aa overlap); and Q9K4H3|SCD66.02
FT                   from Streptomyces coelicolor (95 aa), FASTA scores: opt:
FT                   249, E(): 2.8e-10, (48.5% identity in 99 aa overlap). Some
FT                   weak similarity with Q9ZB84|PCAG PROTOCATECHUATE
FT                   3,4-DIOXYGENASE ALPHA-SUBUNIT from Pseudomonas marginata
FT                   (196 aa), FASTA scores: opt: 109, E(): 1.4, (31.3% identity
FT                   in 83 aa overlap); and other bacterial proteins. Identical
FT                   second copy present as Rv0814c|AL022004|MTV043.06c|SSEC2
FT                   from Mycobacterium tuberculosis (100 aa) (100.0% identity
FT                   in 100 aa overlap). Note that previously known as sseC."
FT                   /db_xref="InterPro:IPR010814"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D986"
FT                   /protein_id="CAE55553.1"
FT                   /translation="MCSGPKQGLTLPASVDLEKETVITGRVVDGDGQAVGGAFVRLLDS
FT                   SDEFTAEVVASATGDFRFFAAPGSWTLRALSAAGNGDAVVQPSGAGIHEVDVKIT"
FT   CDS             17469..17912
FT                   /transl_table=11
FT                   /gene="moaE1"
FT                   /locus_tag="Rv3119"
FT                   /standard_name="moaE"
FT                   /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN
FT                   E MOAE1 (MOLYBDOPTERIN CONVERTING FACTOR LARGE SUBUNIT)
FT                   (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT 2)"
FT                   /function="POSSIBLY A MOLYBDENUM BIOSYNTHESIS COFACTOR.
FT                   CONVERSION OF MOLYBDOPTERIN PRECURSOR Z INTO MOLYBDOPTERIN
FT                   REQUIRES TRANSFER OF TWO SULFUR ATOMS TO PRECURSOR Z (TO
FT                   GENERATE THE DITHIOLENE GROUP). THIS IS CATALYZED BY THE
FT                   CONVERTING FACTOR COMPOSED OF A SMALL AND LARGE SUBUNIT."
FT                   /note="Rv3119, (MTCY164.29), len: 147 aa. Probable moaE1,
FT                   molybdopterin converting factor E (molybdopterin converting
FT                   factor (subunit 2)), highly similar to others e.g.
FT                   O31705|MOAE from Bacillus subtilis (157 aa), FASTA scores:
FT                   opt: 390, E(): 8.6e-19, (43.95% identity in 132 aa
FT                   overlap); Q9K8I7|MOAE|BH3019 from Bacillus halodurans (156
FT                   aa), FASTA scores: opt: 369, E(): 2e-17, (42.4% identity in
FT                   132 aa overlap); P30749|MOAE_ECOLI|CHLA5|B0785 from
FT                   Escherichia coli strain K12 (149 aa), FASTA scores: opt:
FT                   312, E(): 1.1e-13, (38.45% identity in 130 aa overlap);
FT                   etc. Also highly similar (but shorter 74 aa) to
FT                   O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN
FT                   from Mycobacterium tuberculosis (221 aa), FASTA scores:
FT                   opt: 733, E(): 3.9e-41, (76.2% identity in 143 aa overlap);
FT                   and highly similar to O53878|MOAE2|Rv0866|MTV043.59
FT                   PUTATIVE MOLYBDOPTERIN SYNTHASE LARGE SUBUNIT from
FT                   Mycobacterium tuberculosis (141 aa), FASTA scores: opt:
FT                   321, E(): 2.6e-14, (40.9% identity in 132 aa overlap). Note
FT                   that previously known as moaE."
FT                   /db_xref="GOA:O05795"
FT                   /db_xref="HSSP:1NVJ"
FT                   /db_xref="InterPro:IPR003448"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05795"
FT                   /protein_id="CAE55554.1"
FT                   /translation="MANVVAEGAYPYCRLTDQPLSVDEVLAAVSGPEQGGIVIFVGNVR
FT                   DHNAGHDVTRLFYEAYPPMVIRTLMSIIGRCEDKAEGVRVAVAHRTGELQIGDAAVVIG
FT                   ASAPHRAEAFDAARMCIELLKQEVPIWKKEFSSTGAEWVGDRP"
FT   CDS             17909..18511
FT                   /transl_table=11
FT                   /locus_tag="Rv3120"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3120, (MTCY164.30), len: 200 aa. Conserved
FT                   hypothetical protein, with weak similarity to several
FT                   hypothetical proteins and many N-methyl transferases e.g.
FT                   Q9X9V1|ORF8 PUTATIVE METHYLTRANSFERASE from Streptomyces
FT                   coelicolor A3(2) (208 aa), FASTA scores: opt: 177, E():
FT                   0.00011, (34.6% identity in 130 aa overlap);
FT                   Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from
FT                   Streptomyces coelicolor (215 aa), FASTA scores: opt: 147,
FT                   E(): 0.011, (31.3% identity in 166 aa overlap);
FT                   BAB52127|MLL5735 PROBABLE METHYLTRANSFERASE from Rhizobium
FT                   loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 133,
FT                   E(): 0.11, (29.75% identity in 158 aa overlap). Highly
FT                   similar to O53374|Rv3322c|MTV016.22c POSSIBLE
FT                   METHYLTRANSFERASE from Mycobacterium tuberculosis strain
FT                   H37Rv (204 aa), FASTA scores: opt: 691, E(): 1.1e-38,
FT                   (57.0% identity in 200 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O05796"
FT                   /protein_id="CAB08377.1"
FT                   /translation="MSPSPSALLADHPDRIRWNAKYECADPTEAVFAPISWLGDVLQFG
FT                   VPEGPVLELACGRSGTALGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVHAD
FT                   LCSWQSGDGRFALVLCRLFWHPPTFRQACEAVAPGGVVAWEAWRRPIDVARDTRRAEWC
FT                   LKPGQPESELPAGFTVIRVVDTDGSEPSRRIIAQRSL"
FT   CDS             18846..20048
FT                   /transl_table=11
FT                   /gene="cyp141"
FT                   /locus_tag="Rv3121"
FT                   /product="PROBABLE CYTOCHROME P450 141 CYP141"
FT                   /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE
FT                   MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY
FT                   UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND
FT                   XENOBIOTICS."
FT                   /EC_number="1.14.-.-"
FT                   /note="Rv3121, (MTCY164.31), len: 400 aa. Probable cyp141,
FT                   cytochrome P-450 integral membrane protein (EC 1.14.-.-),
FT                   similar to other cytochrome P450-dependent oxidases e.g.
FT                   Q9X5P9|CYP107N1 from Streptomyces lavendulae (410 aa),
FT                   FASTA scores: opt: 825, E(): 3.1e-42, (33.35% identity in
FT                   393 aa overlap); Q59819|OLEP|CYP107D1 from Streptomyces
FT                   antibioticus (407 aa), FASTA scores: opt: 812, E():
FT                   1.9e-41, (34.85% identity in 396 aa overlap);
FT                   O32460|CYP107M1 from Actinomadura hibisca (411 aa), FASTA
FT                   scores: opt: 713, E(): 1.6e-35, (31.05% identity in 396 aa
FT                   overlap); P55544|CPXP_RHISN|CYP112A|Y4LD from Rhizobium sp.
FT                   strain NGR234 (400 aa), FASTA scores: opt: 688, E():
FT                   5.1e-34, (33.0% identity in 406 aa overlap); etc. Also
FT                   similar to MTCY339.44c, MTCY369.22, MTCY50.26, MTCY03C7.11,
FT                   MTCY339.34c, MTCY339.42, MTCY369.11c. Contains cytochrome
FT                   P450 cysteine heme-iron ligand signature (PS00086). BELONGS
FT                   TO THE CYTOCHROME P450 FAMILY."
FT                   /db_xref="GOA:O08362"
FT                   /db_xref="HSSP:1OXA"
FT                   /db_xref="InterPro:IPR017972"
FT                   /db_xref="UniProtKB/Swiss-Prot:O08362"
FT                   /protein_id="CAB08378.1"
FT                   /translation="MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWL
FT                   VTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLN
FT                   PGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELA
FT                   AHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTD
FT                   EQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPA
FT                   TEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFG
FT                   YGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWP
FT                   T"
FT   misc_feature    19860..19889
FT                   /note="PS00086 Cytochrome P450 cysteine heme-iron ligand
FT                   signature"
FT   CDS             20426..20896
FT                   /transl_table=11
FT                   /locus_tag="Rv3122"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3122, (MTCY164.32), len: 156 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O07033"
FT                   /protein_id="CAB08379.1"
FT                   /translation="MYSGCWINNQNGETRVGEDSLEDLEQRRARLYDQLAATGDFRRGS
FT                   ISENYRRCGKPNCVCAQEGHPGHGPRYLWTRTVAGRGTKGRQLSVEEVDKVRAELANYH
FT                   RFAQVSEQIVAVNEAICEARPPNPAATAPPAGTTGHKKGGSATRSRRSSPPR"
FT   CDS             20906..21400
FT                   /transl_table=11
FT                   /locus_tag="Rv3123"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3123, (MTCY164.33), len: 162 aa. Hypothetical
FT                   unknown protein, but N-terminus shares weak similarity with
FT                   N-terminal part of O93439|CMESO-1 BHLH TRANSCRIPTION FACTOR
FT                   from Gallus gallus (Chicken) (287 aa), FASTA scores: opt:
FT                   129, E(): 0.81, (38.75% identity in 80 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O07034"
FT                   /protein_id="CAB08380.1"
FT                   /translation="MRSRSVRWDPRCRPGRSGVGDPHCDDPAGLLAAGAAAGRRHRAPG
FT                   PAHRLRARALRVVRRLPRQEPRYRAGPGPVAPRLLPLPHLRAWDGAPWIWNLATAILPE
FT                   ATPIVDLYHARQHVHDLAGQLAPALGEHHSDWLTARLVDLDSGDIETLVQQPIGQHTGH
FT                   T"
FT   CDS             21843..22712
FT                   /transl_table=11
FT                   /locus_tag="Rv3124"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv3124, (MTCY164.34), len: 289 aa. Probable
FT                   transcriptional regulatory protein, similar to many
FT                   Streptomyces and Mycobacterium tuberculosis regulatory
FT                   proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15
FT                   from Mycobacterium tuberculosis strain H37Rv (388 aa),
FT                   FASTA scores: opt: 963, E(): 2e-56, (55.15% identity in 252
FT                   aa overlap); O53145 from Mycobacterium tuberculosis (381
FT                   aa); P71484|EMBR from Mycobacterium avium (384 aa), FASTA
FT                   scores: opt: 859, E(): 1.5e-49, (52.2% identity in 249 aa
FT                   overlap); Q9XCC3|TYLT from Streptomyces fradiae (404 aa),
FT                   FASTA scores: opt: 462, E(): 3.1e-23, (35.05% identity in
FT                   254 aa overlap); Q9XCC4|TYLS from Streptomyces fradiae (277
FT                   aa), FASTA scores: opt: 456, E(): 5.6e-23, (33.45% identity
FT                   in 269 aa overlap); etc. Start chosen by similarity,
FT                   alternative possible (see AAK47548 from Mycobacterium
FT                   tuberculosis strain CDC1551, longer N-terminus (311 aa))."
FT                   /db_xref="GOA:O05797"
FT                   /db_xref="InterPro:IPR011991"
FT                   /db_xref="UniProtKB/TrEMBL:O05797"
FT                   /protein_id="CAB08381.1"
FT                   /translation="MQFNVLGPLELNLRGTKLPLGTPKQRAVLAMLLLSRNQVVAADAL
FT                   VQAIWEKSPPARARRTVHTYICNLRRTLSDAGVDSRNILVSEPPGYRLLIGDRQQCDLD
FT                   RFVAAKESGLRASAKGYFSEAIRYLDSALQNWRGPVLGDLRSFMFVQMFSRALTEDELL
FT                   VHTKLAEAAIACGRADVVIPKLERLVAMHPYRESLWKQLMLGYYVNEYQSAAIDAYHRL
FT                   KSTLAEELGVEPAPTIRALYHKILRQLPMDDLVGRVTRGRVDLRGGNGAKVEELTESDK
FT                   DLLPIGLA"
FT   CDS             complement(22813..23988)
FT                   /transl_table=11
FT                   /gene="PPE49"
FT                   /locus_tag="Rv3125c"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3125c, (MTCY164.35c), len: 391 aa. Member of the
FT                   Mycobacterium tuberculosis PPE family, similar to other
FT                   e.g. P95247|Rv2352c|MTCY98.21c (391 aa), FASTA scores: opt:
FT                   1576, E(): 3.8e-72, (62.55% identity in 398 aa overlap),
FT                   MTCY98.0029c, MTCY03A2.22c, MTCY10G2.10, MTCY02B10.25c,
FT                   MTCI364.08, M TCY21C12.09c, MTCY48.17."
FT                   /db_xref="InterPro:IPR000030"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q7D631"
FT                   /protein_id="CAE55555.1"
FT                   /translation="MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWASAS
FT                   SFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQARAAATAFEAALA
FT                   ATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDYLEMWAQDVAAMVGYHAGAKSV
FT                   AATLAPFSLPPVSLAGLAAQVGTQVAGMATTASAAVTPVVEGAMASVPTVMSGMQSLVS
FT                   QLPLQHASMLFLPVRILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAAIPAFK
FT                   PLGGRELGAGMSAGLGQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPVALTQAA
FT                   GAAGGGMPMMLMPMSISGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG"
FT   CDS             complement(24145..24459)
FT                   /transl_table=11
FT                   /locus_tag="Rv3126c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3126c, (MTCY164.36c), unknown, len: 104 aa.
FT                   Hypothetical unknown protein. Shortened version of
FT                   MTCY164.36c, avoiding overlap."
FT                   /db_xref="UniProtKB/TrEMBL:O05799"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08398.1"
FT                   /translation="MVIRFDQIGSLVLSMKSLASLSFQRCLRENSSLVAALDRLDAAVD
FT                   ELSALSFDALTTPERDRARRDRDHHPWSRSRSQLSPRMAHGAVHQCQWPKAVWAVIDNP
FT                   "
FT   CDS             24484..25518
FT                   /transl_table=11
FT                   /locus_tag="Rv3127"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3127, (MTCY164.37), len: 344 aa. Hypothetical
FT                   protein, highly similar to Mycobacterium tuberculosis
FT                   protein O53476|Rv2032|MTV018.19 (331 aa), FASTA scores:
FT                   opt: 1212, E(): 6e-69, (56.7% identity in 321 aa overlap),
FT                   and also similar to P95195|MTCY03A2.27c (332 aa), FASTA
FT                   scores: opt: 521, E(): 1.6e-25; (35.0% identity in 326 aa
FT                   overlap). Some similarity to C-terminal half of
FT                   hypothetical Mycobacterium tuberculosis proteins."
FT                   /db_xref="UniProtKB/TrEMBL:O05800"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08361.1"
FT                   /translation="MLKNAVLLACRAPSVHNSQPWRWVAESGSEHTTVHLFVNRHRTVP
FT                   ATDHSGRQAIISCGAVLDHLRIAMTAAHWQANITRFPQPNQPDQLATVEFSPIDHVTAG
FT                   QRNRAQAILQRRTDRLPFDSPMYWHLFEPALRDAVDKDVAMLDVVSDDQRTRLVVASQL
FT                   SEVLRRDDPYYHAELEWWTSPFVLAHGVPPDTLASDAERLRVDLGRDFPVRSYQNRRAE
FT                   LADDRSKVLVLSTPSDTRADALRCGEVLSTILLECTMAGMATCTLTHLIESSDSRDIVR
FT                   GLTRQRGEPQALIRVGIAPPLAAVPAPTPRRPLDSVLQIRQTPEKGRNASDRNARETGW
FT                   FSPP"
FT   CDS             complement(25505..26518)
FT                   /pseudo
FT                   /transl_table=11
FT                   /locus_tag="Rv3128c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3128c, (MTCY164.38c), len: 337 aa. Conserved
FT                   hypothetical protein, similar to other conserved
FT                   hypothetical proteins. This ORF corresponds to a fusion of
FT                   MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon
FT                   but is similar throughout its length to
FT                   Rv2807|MTCY16B7.36c|Z81331 CONSERVED HYPOTHETICAL PROTEIN
FT                   from Mycobacterium tuberculosis (384 aa), FASTA scores:
FT                   opt: 954, E(): 0, (47.2% identity in 339 aa overlap)."
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT   CDS             26997..27329
FT                   /transl_table=11
FT                   /locus_tag="Rv3129"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3129, (MTCY164.40), len: 110 aa. Conserved
FT                   hypothetical protein, with some similarity to various
FT                   hypothetical proteins from Streptomyces coelicolor e.g.
FT                   Q9RI34|SCJ12.26 HYPOTHETICAL 14.5 KDA PROTEIN (137 aa),
FT                   FASTA scores: opt: 141, E(): 0.0016, (39.3% identity in 84
FT                   aa overlap); Q9RI49|SCJ12.09c HYPOTHETICAL 15.8 KDA PROTEIN
FT                   (146 aa), FASTA scores: opt: 141, E(): 0.0017, (38.05%
FT                   identity in 92 aa overlap); Q9RJ05|SCJ1.09C POSSIBLE
FT                   DNA-BINDING PROTEIN (233 aa), FASTA scores: opt: 140, E():
FT                   0.0029, (34.85% identity in 89 aa overlap);
FT                   Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID
FT                   DEHYDROGENASE E1 BETA SUBUNIT (334 aa); etc."
FT                   /db_xref="UniProtKB/TrEMBL:Q7D628"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55557.1"
FT                   /translation="MVQGRTVLFRTAEGAKLFSAVAKCAVAFEADDHNVAEGWSVIVKV
FT                   RAQVLTTDAGVREAERAQLLPWTATLKRHCVRVIPWEITGRHFRFGPEPDRSQTFACEA
FT                   SSHNQR"
FT   CDS             complement(27312..28703)
FT                   /transl_table=11
FT                   /locus_tag="Rv3130c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3130c, (MTCY03A2.28, MTCY164.41c), len: 463 aa.
FT                   Conserved hypothetical protein, similar to several other
FT                   hypothetical Mycobacterium tuberculosis strain H37Rv
FT                   proteins e.g. O06795|YH60_MYCTU|Rv1760|MTCY28.26
FT                   HYPOTHETICAL 54.1 KDA PROTEIN (502 aa), FASTA scores: opt:
FT                   586, E(): 9.8e-29, (28.95% identity in 463 aa overlap)."
FT                   /db_xref="InterPro:IPR004255"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A650"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08399.1"
FT                   /translation="MNHLTTLDAGFLKAEDVDRHVSLAIGALAVIEGPAPDQEAFLSSL
FT                   AQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWRIALPRPGNEDQLFELIADL
FT                   MARRLDRGRPLWEVWVIEGLADSKWAILTKLHHCMADGIAATHLLAGLSDESMSDSFAS
FT                   NIHTTMQSQSASVRRGGFRVNPSEALTASTAVMAGIVRAAKGASEIAAGVLSPAASSLN
FT                   GPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNVLIQRGERPRFDSLR
FT                   TLVPVSTRSNSALSKTDNRVSLMLPNLPVDQENPLQRLRIVHSRLTRAKAGGQRQFGNT
FT                   LMAIANRLPFPMTAWAVGLLMRLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIA
FT                   MQLRTSVAMLSYADDLYFGILADYDVVADAGQLARGIEDAVARLVAISKRRKVTRRRGA
FT                   LSLVV"
FT   CDS             28888..29886
FT                   /transl_table=11
FT                   /locus_tag="Rv3131"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3131, (MTCY03A2.27c), len: 332 aa. Hypothetical
FT                   protein, similar to other hypothetical bacterial proteins
FT                   e.g. O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt:
FT                   568, E(): 2.5e-27, (36.7% identity in 321 aa overlap);
FT                   O05800|Rv3127|MTCY164.37 (344 aa), FASTA scores: opt: 521,
FT                   E(): 1.9e-24, (34.95% identity in 326 aa overlap);
FT                   Q9RI33|SCJ12.27c from Streptomyces coelicolor (335 aa),
FT                   FASTA scores: opt: 441, E(): 1.3e-19, (35.75% identity in
FT                   319 aa overlap); Q9RI44|SCJ12.14 from Streptomyces
FT                   coelicolor (309 aa), FASTA scores: opt: 328, E(): 9.3e-13,
FT                   (27.9% identity in 308 aa overlap); Q9CBP5|ML1751 from
FT                   Mycobacterium leprae (721 aa), FASTA scores: opt: 137, E():
FT                   0.78, (26.15% identity in 298 aa overlap); etc. Equivalent
FT                   to AAK47555 from Mycobacterium tuberculosis strain CDC1551
FT                   but shorter 12 aa."
FT                   /db_xref="GOA:P95195"
FT                   /db_xref="InterPro:IPR000415"
FT                   /db_xref="UniProtKB/TrEMBL:P95195"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06283.1"
FT                   /translation="MNTHFPDAETVRTVLTLAVRAPSIHNTQPWRWRVCPTSLELFSRP
FT                   DMQLRSTDPDGRELILSCGVALHHCVVALASLGWQAKVNRFPDPKDRCHLATIGVQPLV
FT                   PDQADVALAAAIPRRRTDRRAYSCWPVPGGDIALMAARAARGGVMLRQVSALDRMKAIV
FT                   AQAVLDHVTDEEYLRELTIWSGRYGSVAGVPARNEPPSDPSAPIPGRLFAGPGLSQPSD
FT                   VLPADDGAAILALGTETDDRLARLRAGEAASIVLLTATAMGLACCPITEPLEIAKTRDA
FT                   VRAEVFGAGGYPQMLLRVGWAPINADPLPPTPRRELSQVVEWPEELLRQRC"
FT   CDS             complement(29866..31602)
FT                   /transl_table=11
FT                   /gene="devS"
FT                   /locus_tag="Rv3132c"
FT                   /product="TWO COMPONENT SENSOR HISTIDINE KINASE DEVS"
FT                   /function="SENSOR PART OF THE TWO COMPONENT REGULATORY
FT                   SYSTEM DEVR/DEVS. THOUGHT TO CONTROL HSPX|Rv2031|ACR
FT                   EXPRESSION."
FT                   /EC_number="2.7.3.-"
FT                   /note="Rv3132c, (MTCY03A2.26), len: 578 aa. devS,
FT                   membrane-bound two component sensor histidine kinase (EC
FT                   2.7.3.-) (see citations below; dev for Differentially
FT                   Expressed in Virulent strain), similar to others two
FT                   component sensors e.g. Q9RI43|SCJ12.15c PUTATIVE
FT                   TWO-COMPONENT SENSOR from Streptomyces coelicolor (585 aa),
FT                   FASTA scores: opt: 1305, E(): 2.5e-69, (41.35% identity in
FT                   573 aa overlap); Q9ZBY4|SCD78.15 PUTATIVE TWO COMPONENT
FT                   SENSOR from Streptomyces coelicolor (560 aa), FASTA scores:
FT                   opt: 1194, E(): 8.1e-63, (41.05% identity in 558 aa
FT                   overlap); O85371|CPRS TWO COMPONENT REGULATOR from
FT                   Rhodococcus sp (563 aa), FASTA scores: opt: 803, E():
FT                   8.3e-40, (38.4% identity in 552 aa overlap);
FT                   Q9L094|SCC24.23 PUTATIVE TWO-COMPONENT SENSOR HISTIDINE
FT                   KINASE from Streptomyces coelicolor (similarity only in
FT                   C-terminus for this one); etc. Also highly similar to
FT                   mycobacterium O53473|Rv2027c|MTV018.14c PUTATIVE MEMBRANE
FT                   PROTEIN (573 aa), FASTA scores: opt: 2333, E(): 7.6e-130,
FT                   (61.45% identity in 576 aa overlap). TBparse score is
FT                   0.921."
FT                   /db_xref="GOA:P95194"
FT                   /db_xref="InterPro:IPR011712"
FT                   /db_xref="PDB:2W3D"
FT                   /db_xref="UniProtKB/TrEMBL:P95194"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06282.1"
FT                   /translation="MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGR
FT                   DRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGID
FT                   EETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVR
FT                   DESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDI
FT                   ATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVA
FT                   SIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVV
FT                   VLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVI
FT                   QRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQ
FT                   RIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRV
FT                   KVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPL
FT                   SQ"
FT   CDS             complement(31599..32252)
FT                   /transl_table=11
FT                   /gene="devR"
FT                   /locus_tag="Rv3133c"
FT                   /product="TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   DEVR (PROBABLY LUXR/UHPA-FAMILY)"
FT                   /function="REGULATOR PART OF THE TWO COMPONENT REGULATORY
FT                   SYSTEM DEVR/DEVS. CONTROLS HSPX|Rv2031|ACR EXPRESSION."
FT                   /note="Rv3133c, (MTCY03A2.25), len: 217 aa. devR, two
FT                   component transcriptional regulator (see Dasgupta et al.,
FT                   2000; dev for Differentially Expressed in Virulent strain),
FT                   highly similar to several e.g. O85372|CPRR TWO COMPONENT
FT                   REGULATOR from Rhodococcus sp. (212 aa), FASTA scores: opt:
FT                   868, E(): 6.2e-46, (65.05% identity in 206 aa overlap);
FT                   Q9RI42|SCJ12.16c PUTATIVE LUXR FAMILY TWO-COMPONENT
FT                   RESPONSE REGULATOR from Streptomyces coelicolor (233 aa),
FT                   FASTA scores: opt: 849, E(): 9.7e-45, (60.55% identity in
FT                   218 aa overlap); Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT
FT                   SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces
FT                   coelicolor (218 aa), FASTA scores: opt: 835, E(): 6.5e-44,
FT                   (61.55% identity in 208 aa overlap); and similar to others.
FT                   Contains bacterial regulatory proteins, LuxR family
FT                   signature (PS00622) near C-terminus as seen in bvgA, comA,
FT                   dctR, degU, evgA, fimZ, fixJ, gacA, glpR, narL, narP, nodW,
FT                   rcsB and uhpA. Helix-turn-helix motif at 166-187 (+3.15
FT                   SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL
FT                   REGULATORS. THE N-TERMINAL REGION IS SIMILAR TO THAT OF
FT                   OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION
FT                   SYSTEMS."
FT                   /db_xref="GOA:P95193"
FT                   /db_xref="InterPro:IPR000792"
FT                   /db_xref="PDB:1ZLJ"
FT                   /db_xref="UniProtKB/TrEMBL:P95193"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06281.1"
FT                   /translation="MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPA
FT                   ARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVK
FT                   DIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSE
FT                   GLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP"
FT   misc_feature    complement(31680..31763)
FT                   /note="PS00622 Bacterial regulatory proteins, luxR family
FT                   signature"
FT   CDS             complement(32280..33086)
FT                   /transl_table=11
FT                   /locus_tag="Rv3134c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN. COULD PLAY A ROLE IN THE ADAPTATION TO
FT                   HYPOXIA, PARTICIPATING IN THE PHOSPHORELAY IN THE TWO
FT                   COMPONENT REGULATORY SYSTEM DEVR|Rv3133c/DEVS|Rv3132c."
FT                   /note="Rv3134c, (MTCY03A2.240, len: 268 aa. Ala-, Val- rich
FT                   protein (see citations below), related to other
FT                   hypothetical Mycobacterium tuberculosis proteins e.g.
FT                   O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 562,
FT                   E(): 3.2e-28, (40.65% identity in 273 aa overlap);
FT                   O06188|Rv2624c|MTCY01A10.08 (272 aa), FASTA scores: opt:
FT                   458, E(): 1.1e-21, (36.55% identity in 271 aa overlap);
FT                   O53472|R2026c|MTV018.13c (294 aa), FASTA scores: opt: 232,
FT                   E(): 1.9e-07, (30.45% identity in 276 aa overlap); etc.
FT                   Shares some similarity with other hypothetical proteins
FT                   from Streptomyces coelicolor e.g. Q9RIZ8|SCJ1.16c (294 aa),
FT                   FASTA scores: opt: 207, E(): 6.9e-06, (28.9% identity in
FT                   263 aa overlap); Q9K4L5|SC5F8.09 PUTATIVE STRESS-INDUCIBLE
FT                   PROTEIN (312 aa), FASTA scores: opt: 204, E(): 1.1e-05,
FT                   (28.4% identity in 271 aa overlap); etc. Equivalent to
FT                   AAK47558|MT3220 Universal stress protein family from
FT                   Mycobacterium tuberculosis strain CDC1551 (268 aa). Rv3134c
FT                   seems cotranscribed with devR-devS (see Sherman et al.,
FT                   2001)."
FT                   /db_xref="GOA:P95192"
FT                   /db_xref="InterPro:IPR006015"
FT                   /db_xref="UniProtKB/TrEMBL:P95192"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06280.1"
FT                   /translation="MSDPRPARAVVVGIDGSRAATHAALWAVDEAVNRDIPLRLVYVID
FT                   PSQLSAAGEGGGQSAARAALHDASRKVEATGQPVKIETEVLCGRPLTKLMQESRSAAML
FT                   CVGSVGLDHVRGRRGSVAATLAGSALCPVAVIHPSPAEPATTSQVSAVVAEVDNGVVLR
FT                   HAFEEARLRGVPLRAVAVHAAETPDDVEQGSRLAHVHLSRRLAHWTRLYPEVRVDRAIA
FT                   GGSACRHLAANAKPGQLFVADSHSAHELCGAYQPGCAVLTVRSANL"
FT   CDS             33671..34069
FT                   /transl_table=11
FT                   /gene="PPE50"
FT                   /locus_tag="Rv3135"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3135, (MTCY03A2.23c), len: 132 aa. Member of the
FT                   Mycobacterium tuberculosis Ala-, Gly-rich PPE family,
FT                   similar to P95190|Rv3136|MTCY03A2.22c (380 aa), FASTA
FT                   scores: opt: 494, E(): 6.7e-25, (57.25% identity in 131 aa
FT                   overlap) (next ORF downstream), MTY21C12_9, MTCY3C7_24,
FT                   MTCI125_27, MTV049_12, MTV049_9, MTV049_11 , MTCY274_24
FT                   etc. TBparse score is 0.912."
FT                   /db_xref="InterPro:IPR000030"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q6MX07"
FT                   /protein_id="CAE55558.1"
FT                   /translation="MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENY
FT                   GSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTATQARAAAAAFEQAHAMT
FT                   VPPALVTGIRGAIVVETASASNTAGTPP"
FT   CDS             34131..35273
FT                   /transl_table=11
FT                   /gene="PPE51"
FT                   /locus_tag="Rv3136"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3136, (MTCY03A2.22c), len: 380 aa. Member of the
FT                   Mycobacterium tuberculosis Ala-, Gly-rich PPE family,
FT                   similar to Q9AGF0|Ov2770c Rv2770c-LIKE PROTEIN from M.
FT                   microti (397 aa), FASTA scores: opt: 917, E(): 9e-41,
FT                   (46.15% identity in 388 aa overlap);
FT                   O33312|Rv2770c|MTV002.35c, MTV002_36, MTCI125_26,
FT                   MTCY10G2_10, MTCI364_8, MTV049_28, MTV049_29, etc. TBparse
FT                   score is 0.923."
FT                   /db_xref="InterPro:IPR000030"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q7D623"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55559.1"
FT                   /translation="MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAELATTAEAY
FT                   GSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTAIQARAAALAFEQAYAMT
FT                   LPPPVVAANRIQLLALIATNFFGQNTAAIAATEAQYAEMWAQDAAAMYGYATASAAAAL
FT                   LTPFSPPRQTTNPAGLTAQAAAVSQATDPLSLLIETVTQALQALTIPSFIPEDFTFLDA
FT                   IFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEVTPGDFGIGELVSATSPGG
FT                   GVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSALSPAGLTTLPGTD
FT                   VAEHGMPGVPGVPVAAGRASGVLPRYGVRLTVMAHPPAAG"
FT   CDS             35730..36512
FT                   /transl_table=11
FT                   /locus_tag="Rv3137"
FT                   /product="PROBABLE MONOPHOSPHATASE"
FT                   /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM."
FT                   /EC_number="3.1.3.-"
FT                   /note="Rv3137, (MTCY03A2.21c), len: 260 aa. Probable
FT                   monophosphatase (EC 3.1.3.-), equivalent to
FT                   O32889|MLCB1779_19|ML0662 PUTATIVE MONOPHOSPHATASE from
FT                   Mycobacterium leprae (255 aa), FASTA scores: opt: 1403,
FT                   E(): 1.2e-81, (81.8% identity in 253 aa overlap). Also
FT                   similar to Q9K4B1|SC7E4.05c from Streptomyces coelicolor
FT                   (266 aa), FASTA scores: opt: 969, E(): 3.5e-54, (57.9%
FT                   identity in 259 aa overlap); Q53743|PUR3 MONO-PHOSPHATASE
FT                   from Streptomyces lipmanii (Streptomyces alboniger) (273
FT                   aa), FASTA scores: opt: 862, E(): 2.1e-47, (55.25% identity
FT                   in 257 aa overlap); BAB50023|MLL3039 MONO-PHOSPHATASE from
FT                   Rhizobium loti (Mesorhizobium loti) (262 aa), FASTA scores:
FT                   opt: 448, E(): 3.2e-21, (31.37% identity in 255 aa
FT                   overlap); etc. Contains inositol monophosphatase family
FT                   signature 1 (PS00629). TBparse score is 0.881."
FT                   /db_xref="GOA:P95189"
FT                   /db_xref="HSSP:1KA1"
FT                   /db_xref="InterPro:IPR017955"
FT                   /db_xref="UniProtKB/TrEMBL:P95189"
FT                   /protein_id="CAB06277.1"
FT                   /translation="MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADR
FT                   AVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLIAL
FT                   LEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSSLS
FT                   GWARPGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVR
FT                   EAGGRLTSLDGVAGPHGGSAVATNGLLHDEVLTRLNAG"
FT   misc_feature    35967..36008
FT                   /note="PS00629 Inositol monophosphatase family signature 1"
FT   CDS             36532..37620
FT                   /transl_table=11
FT                   /gene="pflA"
FT                   /locus_tag="Rv3138"
FT                   /product="PROBABLE PYRUVATE FORMATE LYASE ACTIVATING
FT                   PROTEIN PFLA (FORMATE ACETYLTRANSFERASE ACTIVATING ENZYME)
FT                   ([PYRUVATE FORMATE-LYASE] ACTIVATING ENZYME)"
FT                   /function="INVOLVED IN CELLULAR METABOLISM [CATALYTIC
FT                   ACTIVITY: S-adenosyl-L-methionine + dihydroflavodoxin +
FT                   [formate acetyltransferase]-glycine = 5'-deoxyadenosine +
FT                   methionine + flavodoxin + [formate
FT                   acetyltransferase]-glycine-2-yl radical]."
FT                   /EC_number="1.97.1.4"
FT                   /note="Rv3138, (MTCY03A2.20c), len: 362 aa. Probable pflA,
FT                   pyruvate formate lyase activating protein (EC 1.97.1.4),
FT                   similar to other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi
FT                   (348 aa), FASTA scores: opt: 926, E(): 1.1e-52, (39.95%
FT                   identity in 343 aa overlap); O27446|MTH1395 from
FT                   Methanobacterium thermoautotrophicum (335 aa), FASTA
FT                   scores: opt: 909, E(): 1.3e-51, (42.2% identity in 327 aa
FT                   overlap); O28939|AF1330 from Archaeoglobus fulgidus (336
FT                   aa), FASTA scores: opt: 884, E(): 5.6e-50, (42.0% identity
FT                   in 319 aa overlap); etc. Also similar to O50099|PH1391
FT                   HYPOTHETICAL 40.2 KDA PROTEIN from Pyrococcus horikoshii
FT                   (348 aa), FASTA scores: opt: 934, E(): 3.3e-53, (40.5%
FT                   identity in 343 aa overlap); and other hypothetical
FT                   proteins. TBparse score is 0.881."
FT                   /db_xref="GOA:P95188"
FT                   /db_xref="InterPro:IPR016431"
FT                   /db_xref="UniProtKB/TrEMBL:P95188"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06292.1"
FT                   /translation="MSDPFTIATKHWHRLHDSRIQCDVCPRACKLHEGQRGLCFVRGRF
FT                   DDQVKLTSYGRSSGFCVDPIEKKPLNHFLPGSATLSFGTAGCNLACKFCQNWDISKSRE
FT                   IDVLASRAAPADIARTAHELGCRSVAFTYNDPTIFWEYAADVADACHDQGIKAVAVTAG
FT                   YMCPEPRAEFYRRVDAANVDLKAFTEDFYRKVCVSHLRNVLDTLAYLRHQTNVWLEITT
FT                   LLIPGRNDSDAEVAAECRWIRENLGVDVPVHFTAFHPDYKMMDTPATPTATLTRAREIG
FT                   IGEGLRFVYTGNVHDAVGGSTSCPGCRATVIVRDWYSIRHYALTEDGRCQACGYQMPGV
FT                   YDGPAGHWGQRRLPLLTSLSRM"
FT   CDS             37700..39106
FT                   /transl_table=11
FT                   /gene="fadE24"
FT                   /locus_tag="Rv3139"
FT                   /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE24"
FT                   /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION."
FT                   /EC_number="1.3.99.-"
FT                   /note="Rv3139, (MTCY03A2.19c), len: 468 aa. Probable
FT                   fadE24, acyl-CoA dehydrogenase (1.3.99.-), equivalent to
FT                   O32890|MLCB1779.30|FADE24|ML0661 PUTATIVE ACYL-CoA
FT                   DEHYDROGENASE from Mycobacterium leprae (465 aa), FASTA
FT                   scores: opt: 2587, E(): 4e-153, (83.6% identity in 464 aa
FT                   overlap). Similar to other e.g. Q9HUH0|PA4995 from
FT                   Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 1139,
FT                   E(): 2.8e-63, (45.3% identity in 426 aa overlap);
FT                   Q9K6D0|MMGC|BH3799 from Bacillus halodurans (379 aa), FASTA
FT                   scores: opt: 603, E(): 4.7e-30, (30.3% identity in 366 aa
FT                   overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380
FT                   aa), FASTA scores: opt: 601, E(): 6.3e-30, (32.25% identity
FT                   in 363 aa overlap); etc. Contains acyl-CoA dehydrogenases
FT                   signature 2 (PS00073) near C-terminus. BELONGS TO THE
FT                   ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.881."
FT                   /db_xref="GOA:P95187"
FT                   /db_xref="HSSP:3MDE"
FT                   /db_xref="InterPro:IPR006092"
FT                   /db_xref="UniProtKB/TrEMBL:P95187"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06276.1"
FT                   /translation="MTNTTSAANAAKPSGARTDRRGRTTGVGLAPHKRTGIDVALALLT
FT                   PIVGQEFLDKYRLRDPLNRSLRYGVKTMFATAGAATRQFQRVQGLRGGPTRLKSSGRDY
FT                   FDLTPDDDQKLIIETVDEFAEEVLRPAAHDADDAATYPSDLTAKAAELGITAINIPEDF
FT                   DGIAEHRSSVTNVLVAEALAYGDMGLALPILAPGGVASALTHWGSADQQATYLKEFAGE
FT                   NVPQACVAITEPQPLFDPTRLKTTAVRTPSGYRLDGVKSLIPAAADAELFIVGAQLGGK
FT                   PALFIVESAASGLTVKADPSMGIRGAALGQVELCGVSVPLNARLGEDEASDNDYSEALA
FT                   LARLGWAALAVGTSHAVLDYVVPYVKQRQAFGEPIAHRQAVAFMCANIAIELDGLRLIT
FT                   WRGASRAEQGLPFAREAALAKRLGSDKGMQIGLDGVQLLGGHGYTKEHPVERWYRDLRA
FT                   IGVAEGVVVI"
FT   misc_feature    39005..39064
FT                   /note="PS00073 Acyl-CoA dehydrogenases signature 2"
FT   CDS             39127..40332
FT                   /transl_table=11
FT                   /gene="fadE23"
FT                   /locus_tag="Rv3140"
FT                   /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE23"
FT                   /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION."
FT                   /note="Rv3140, (MTCY03A2.18c), len: 401 aa. Probable
FT                   fadE23, acyl-CoA dehydrogenase (1.3.99.-) (see citation
FT                   below), equivalent to O32891|MLCB1779.31|FADE23|ML0660
FT                   PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae
FT                   (400 aa), FASTA scores: opt: 2307, E(): 3e-136, (89.5%
FT                   identity in 401 aa overlap). Also similar to others e.g.
FT                   Q9HUH1|PA4994 from Pseudomonas aeruginosa (402 aa), FASTA
FT                   scores: opt: 1558, E(): 1.2e-89, (61.0% identity in 400 aa
FT                   overlap); O31251 from Acinetobacter sp. ADP1 (401 aa),
FT                   FASTA scores: opt: 1509, E(): 1.3e-86, (58.2% identity in
FT                   402 aa overlap); Q9K6D1|ACDA OR BH3798 from Bacillus
FT                   halodurans (380 aa), FASTA scores: opt: 612, E(): 8.4e-31,
FT                   (38.2% identity in 293 aa overlap); Q9AHX9|FADFX from
FT                   Pseudomonas putida (375 aa), FASTA scores: opt: 584, E():
FT                   4.6e-29, (32.7% identity in 379 aa overlap); etc. COULD
FT                   BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score
FT                   is 0.890."
FT                   /db_xref="GOA:P95186"
FT                   /db_xref="HSSP:3MDE"
FT                   /db_xref="InterPro:IPR013764"
FT                   /db_xref="UniProtKB/TrEMBL:P95186"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06275.1"
FT                   /translation="MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELD
FT                   TLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPY
FT                   QGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKI
FT                   FVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRF
FT                   DNARIPKGNLLGNPEIEVGKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAG
FT                   VEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGR
FT                   MASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSE
FT                   LK"
FT   CDS             40432..41403
FT                   /transl_table=11
FT                   /gene="fadB4"
FT                   /locus_tag="Rv3141"
FT                   /product="PROBABLE NADPH QUINONE OXIDOREDUCTASE FADB4
FT                   (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN)"
FT                   /function="INVOLVED IN LIPID DEGRADATION [CATALYTIC
FT                   ACTIVITY: NADPH + QUINONE = NADP(+) + SEMIQUINONE]."
FT                   /EC_number="1.6.5.5"
FT                   /note="Rv3141, (MTCY03A2.17c), len: 323 aa. Probable fadB4,
FT                   quinone oxidoreductase (EC 1.6.5.5), showing strong
FT                   similarity to variety of quinone oxidoreductases and
FT                   domains in polyketide and fatty acid synthases e.g.
FT                   Q9HTV6|PA5234 PROBABLE OXIDOREDUCTASE from Pseudomonas
FT                   aeruginosa (325 aa), FASTA scores: opt: 737, E(): 1.4e-35,
FT                   (39.65% identity in 328 aa overlap); Q9RYQ7|DRA0251
FT                   PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus
FT                   radiodurans (336 aa), FASTA scores: opt: 688, E(): 1e-32,
FT                   (40.6% identity in 325 aa overlap); Q9RVG8|DR1061 PUTATIVE
FT                   NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans
FT                   (388 aa), FASTA scores: opt: 559, E(): 3.3e-25, (36.3%
FT                   identity in 325 aa overlap); BAB49685|MLL2594 PROBABLE
FT                   QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium
FT                   loti) (326 aa), FASTA scores: opt: 519, E(): 5.9e-23,
FT                   (34.25% identity in 330 aa overlap); Q9LXZ4|T5P19_110
FT                   QUINONE REDUCTASE-LIKE PROTEIN from Arabidopsis thaliana
FT                   (348 aa), FASTA scores: opt: 517, E(): 8.1e-23, (33.55%
FT                   identity in 322 aa overlap); etc. Also similar to
FT                   Q9AA38|CC0770 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from
FT                   Caulobacter crescentus (325 aa), FASTA scores: opt: 673,
FT                   E(): 7.2e-32, (40.2% identity in 326 aa overlap); and
FT                   Q9ABX4|CC0096 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from
FT                   Caulobacter crescentus (332 aa), FASTA scores: opt: 623,
FT                   E(): 5.7e-29, (40.7% identity in 334 aa overlap). Also
FT                   resembles Mycobacterium tuberculosis proteins
FT                   P96826|Rv0149|MTCI5_23, MTCY13D12.11, MTCY24G1.03,
FT                   MTCY19H9.01. BELONGS TO THE ZINC-CONTAINING ALCOHOL
FT                   DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY.
FT                   TBparse score is 0.904. Thought to be differentially
FT                   expressed within host cells (see Triccas et al., 1999)."
FT                   /db_xref="GOA:P95185"
FT                   /db_xref="HSSP:1IYZ"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:P95185"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06274.1"
FT                   /translation="MRAVRVTRLEGPDAVEVAEVEEPTSAGVVIEVHAAGVAFPDALLT
FT                   RGRYQYRPEPPFVLGAEIAGVVRSAPDNSQVRSGDRVVGLTMLTGGMAEVAVLSPERVF
FT                   KLPDNMTFEAGAGVLFNDLTVYFALAVRGRLQAGETVLVHGAAGGIGTSTLRLAPALGA
FT                   SRTVAVVSTQEKAELATVAGATDVVLAEGFKDAVQELTNGRGVDIVVDPVGGDRFTDSL
FT                   RSLAAGGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWSLTHPDALAQQWSQLER
FT                   LLRSGKLPPPEPVVYPLDQAAAAIASLENRTAKGKVVLRVRD"
FT   CDS             complement(41455..41883)
FT                   /transl_table=11
FT                   /locus_tag="Rv3142c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3142c, (MTCY03A2.16), len: 142 aa. Hypothetical
FT                   unknown protein. Equivalent to AAK47569 from Mycobacterium
FT                   tuberculosis strain CDC1551 but shorter 33 aa. TBparse
FT                   score is 0.921."
FT                   /db_xref="UniProtKB/TrEMBL:P95184"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06273.1"
FT                   /translation="MTEQEMTEQWLEGCAVQRIMFRDGLVLNFDDYNELVISVPLQLTL
FT                   PAIETSPAEVVAIDPNDPADHERPLFDFAGATCTAFVWYDTGDLHLEFSDGHQIDVHPD
FT                   DRVTAWELYGKYHGYAACLAPGKLRVVRHDVADANGDQ"
FT   CDS             41991..42392
FT                   /transl_table=11
FT                   /locus_tag="Rv3143"
FT                   /product="PROBABLE RESPONSE REGULATOR"
FT                   /function="UNKNOWN, BUT COULD BE INVOLVED IN REGULATORY
FT                   MECHANISM"
FT                   /note="Rv3143, (MTCY03A2.15c), len: 133 aa. Probable
FT                   response regulator, similar to other sensory transduction
FT                   regulatory proteins e.g. Q9X810|SC6G10.25 from Streptomyces
FT                   coelicolor (133 aa), FASTA scores: opt: 474, E(): 2.8e-24,
FT                   (54.15% identity in 120 aa overlap); Q9KZ82|SCE25.04c from
FT                   Streptomyces coelicolor (225 aa), FASTA scores: opt: 144,
FT                   E(): 0.016, (32.3% identity in 127 aa overlap);
FT                   Q9RZT4|DRB0029 from Deinococcus radiodurans (416 aa), FASTA
FT                   scores: opt: 145, E(): 0.024, (30.65% identity in 124 aa
FT                   overlap). SIMILAR TO OTHER REGULATORY COMPONENTS OF SENSORY
FT                   TRANSDUCTION SYSTEMS."
FT                   /db_xref="GOA:P95183"
FT                   /db_xref="InterPro:IPR001789"
FT                   /db_xref="UniProtKB/TrEMBL:P95183"
FT                   /protein_id="CAB06272.1"
FT                   /translation="MPDSSTALRILVYSDNVQTRERVMRALGKRLHPDLPDLTYVEVAT
FT                   GPMVIRQMDRGGIDLAILDGEATPTGGMGIAKQLKDELASCPPILVLTGRPDDTWLASW
FT                   SRAEAAVPHPVDPIVLGRTVLSLLRAPAH"
FT   CDS             complement(42425..43654)
FT                   /transl_table=11
FT                   /gene="PPE52"
FT                   /locus_tag="Rv3144c"
FT                   /product="PPE-FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3144c, (MTCY03A2.14), len: 409 aa. Member of the
FT                   Mycobacterium tuberculosis PPE family, Gly-, Ala-rich,
FT                   similar to others e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa),
FT                   FASTA scores: opt: 1007, E(): 5.2e-35, (56.2% identity in
FT                   306 aa overlap); and MTV014_3, MTCY6G11_5, MTCY98.0034c,
FT                   MTCY31.06c, MTCY48.17, MTCY98.0029c, MTCY03C7.17c, etc.
FT                   TBparse score is 0.891."
FT                   /db_xref="InterPro:IPR000030"
FT                   /db_xref="UniProtKB/TrEMBL:Q6MX05"
FT                   /protein_id="CAE55560.1"
FT                   /translation="MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSF
FT                   ASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQAAT
FT                   VLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASAIAA
FT                   QVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGTGGATASGGGVG
FT                   YVGSGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPLA
FT                   LAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVA
FT                   AKAAPLSTTRVGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVR
FT                   KDPKIQMRGG"
FT   CDS             44019..44405
FT                   /transl_table=11
FT                   /gene="nuoA"
FT                   /locus_tag="Rv3145"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN A) NUOA
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN A)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3145, (MTCY03A2.13c), len: 128 aa. Probable nuoA,
FT                   integral membrane NADH dehydrogenase, chain A (EC 1.6.5.3),
FT                   similar to others e.g. Q9XAQ4|NUOA from Streptomyces
FT                   coelicolor (119 aa), FASTA scores: opt: 405, E(): 5.4e-20,
FT                   (68.75% identity in 128 aa overlap); Q9RU86|DR1506 from
FT                   Deinococcus radiodurans (160 aa), FASTA scores: opt: 327,
FT                   E(): 9e-15, (40.3% identity in 124 aa overlap);
FT                   BAB47039|NDHC from Triticum aestivum (Wheat), FASTA scores:
FT                   opt: 273, E(): 2.6e-11, (38.1% identity in 126 aa overlap);
FT                   etc. Also similar to a NADH-PLASTOQUINONE OXIDOREDUCTASES
FT                   e.g. P26303|NU3C_WHEAT|NDHC from Triticum aestivum (Wheat)
FT                   (120 aa), FASTA scores: opt: 273, E(): 2.6e-1, (38.1%
FT                   identity in 126 aa overlap). BELONGS TO THE COMPLEX I
FT                   SUBUNIT 3 FAMILY. TBparse score is 0.895."
FT                   /db_xref="GOA:P65563"
FT                   /db_xref="InterPro:IPR000440"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65563"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06271.1"
FT                   /translation="MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGI
FT                   EPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFALVE
FT                   MAIFMLTVFVAYAYVWRRGGLTWD"
FT   CDS             44414..44968
FT                   /transl_table=11
FT                   /gene="nuoB"
FT                   /locus_tag="Rv3146"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN B) NUOB
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN B)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3146, (MTCY03A2.12c), len: 184 aa. Probable nuoB,
FT                   NADH dehydrogenase, chain B (EC 1.6.5.3), similar to others
FT                   e.g. Q9XAQ5|NUOB from Streptomyces coelicolor (184 aa),
FT                   FASTA scores: opt: 989, E(): 1.4e-56, (78.25% identity in
FT                   184 aa overlap); Q56218|NQO6_THETH|NQO6 from Thermus
FT                   aquaticus (subsp. thermophilus) (181 aa), FASTA scores:
FT                   opt: 720, E(): 2.6e-39, (64.45% identity in 152 aa
FT                   overlap); Q9RU87|DR1505 from Deinococcus radiodurans (181
FT                   aa), FASTA scores: opt: 719, E(): 3e-39, (62.6% identity in
FT                   155 aa overlap); etc. BELONGS TO THE COMPLEX I 20 KDA
FT                   SUBUNIT FAMILY. MAY CONTAIN AN IRON-SULFUR 4FE-4S CLUSTER.
FT                   TBparse score is 0.912."
FT                   /db_xref="GOA:P65575"
FT                   /db_xref="InterPro:IPR014406"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65575"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06270.1"
FT                   /translation="MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMAT
FT                   AGPRFDIARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCA
FT                   SSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQQMPLGINRERAI
FT                   AEAEEAALLARPTIEMRGLLR"
FT   CDS             44965..45675
FT                   /transl_table=11
FT                   /gene="nuoC"
FT                   /locus_tag="Rv3147"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN C) NUOC
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN C)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3147, (MTCY03A2.11c), len: 236 aa. Probable nuoC,
FT                   NADH dehydrogenase, chain C (EC 1.6.5.3), similar to others
FT                   e.g. Q9XAQ6|NUOC from Streptomyces coelicolor (251 aa),
FT                   FASTA scores: opt: 1113, E(): 2.6e-64, (67.35% identity in
FT                   236 aa overlap); Q9A6X2|CC1954 from Caulobacter crescentus
FT                   (197 aa), FASTA scores: opt: 351, E(): 1.6e-15, (41.65%
FT                   identity in 132 aa overlap); BAB48757|MLL1369 from
FT                   Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores:
FT                   opt: 347, E(): 3e-15, (42.4% identity in 132 aa overlap);
FT                   etc. Also similar to Q9UUU0|NUGM NUGM PROTEIN PRECURSOR (EC
FT                   1.6.99.3) from Yarrowia lipolytica (Candida lipolytica)
FT                   (281 aa), FASTA scores: opt: 356, E(): 1.1e-15, (34.55%
FT                   identity in 162 aa overlap). Also similar to MTCY251.05,
FT                   FASTA score: E():4.9e-05. Equivalent to AAK47574 from
FT                   Mycobacterium tuberculosis strain CDC1551 but longer 26 aa.
FT                   BELONGS TO THE COMPLEX I 30 KDA SUBUNIT FAMILY. TBparse
FT                   score is 0.893."
FT                   /db_xref="GOA:P65571"
FT                   /db_xref="InterPro:IPR020396"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65571"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06269.1"
FT                   /translation="MSPPNQDAQEGRPDSPTAEVVDVRRGMFGVSGTGDTSGYGRLVRQ
FT                   VVLPGSSPRPYGGYFDDIVDRLAEALRHERVEFEDAVEKVVVYRDELTLHVRRDLLPRV
FT                   AQRLRDEPELRFELCLGVSGVHYPHETGRELHAVYPLQSITHNRRLRLEVSAPDSDPHI
FT                   PSLFAIYPTNDWHERETYDFFGIIFDGHPALTRIEMPDDWQGHPQRKDYPLGGIPVEYK
FT                   GAQIPPPDERRGYN"
FT   CDS             45675..46997
FT                   /transl_table=11
FT                   /gene="nuoD"
FT                   /locus_tag="Rv3148"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN D) NUOD
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN D)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3148, (MTCY03A2.10c), len: 440 aa. Probable nuoD,
FT                   NADH dehydrogenase, chain B (EC 1.6.5.3), similar to others
FT                   e.g. Q9XAQ7|NUOD from Streptomyces coelicolor (440 aa),
FT                   FASTA scores: opt: 2198, E(): 1e-131, (73.9% identity in
FT                   429 aa overlap); P15689|NUCM_PARTE from Paramecium
FT                   tetraurelia (400 aa), FASTA scores: opt: 922, E(): 5.8e-51,
FT                   (38.5% identity in 408 aa overlap);
FT                   Q9RU89|NUOD_DEIRA|DR1503 from Deinococcus radiodurans (401
FT                   aa), FASTA scores: opt: 922, E(): 5.8e-51, (47.75% identity
FT                   in 404 aa overlap); etc. Equivalent to AAK47575 from
FT                   Mycobacterium tuberculosis strain CDC1551 but longer 42 aa.
FT                   Contains helix-turn-helix motif at aa 340-361. BELONGS TO
FT                   THE COMPLEX I 49 KDA SUBUNIT FAMILY."
FT                   /db_xref="GOA:P65569"
FT                   /db_xref="InterPro:IPR014029"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65569"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06291.1"
FT                   /translation="MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGP
FT                   QHPSTHGVLRLILEIEGETVVEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPF
FT                   FNETAYCLGVEKLLGITDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTPMFV
FT                   GFRAREIVLTLFEKITGLRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGEL
FT                   LNENAIWKARTQGVGYLDLTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVIT
FT                   DDSCDAYGRYMIRVKEMWESMKIVEQCLDKLRPGPTMISDRKLAWPADLQVGPDGLGNS
FT                   PKHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRV
FT                   HYRDPSFTNLQSVAAMCEGGMVADLIAAVASIDPVMGGVDR"
FT   CDS             46994..47752
FT                   /transl_table=11
FT                   /gene="nuoE"
FT                   /locus_tag="Rv3149"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN E) NUOE
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN E)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3149, (MTCY03A2.09c), len: 252 aa. Probable nuoE,
FT                   NADH dehydrogenase, chain E (EC 1.6.5.3), similar to others
FT                   e.g. Q9XAQ8|NUOE from Streptomyces coelicolor (290 aa),
FT                   FASTA scores: opt: 1002, E(): 5.7e-55, (69.5% identity in
FT                   213 aa overlap); P40915|NUHM_NEUCR|NUO-24 from Neurospora
FT                   crassa (263 aa), FASTA scores: opt: 412, E(): 1.9e-18,
FT                   (38055% identity in 192 aa overlap); P19234|NUHM_RAT from
FT                   Rattus norvegicus (Rat) (241 aa), FASTA scores: opt: 410,
FT                   E(): 2.4e-18, (23.9% identity in 237 aa overlap); etc.
FT                   BELONGS TO THE COMPLEX I 24 KDA SUBUNIT FAMILY. BINDS A
FT                   2FE-2S CLUSTER (POTENTIAL)."
FT                   /db_xref="GOA:P65573"
FT                   /db_xref="InterPro:IPR012335"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65573"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06290.1"
FT                   /translation="MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAK
FT                   EIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYRRR
FT                   PTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACDYAP
FT                   VVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEG
FT                   QGGPGAPTLAGLQVARKNDMQAPPTPGADE"
FT   CDS             47749..49086
FT                   /transl_table=11
FT                   /gene="nuoF"
FT                   /locus_tag="Rv3150"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN F) NUOF
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN F)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3150, (MTCY03A2.08c), len: 445 aa. Probable nuoF,
FT                   NADH dehydrogenase, chain F (EC 1.6.5.3), similar to others
FT                   e.g. Q9XAQ9|NUOF_STRCO from Streptomyces coelicolor (449
FT                   aa), FASTA scores: opt: 2314, E(): 3.5e-139, (76.25%
FT                   identity in 434 aa overlap); NUF2_RHIME from Rhizobium
FT                   meliloti (421 aa), FASTA scores: opt: 1545, E(): 1.8e-90,
FT                   (53.1% identity in 424 aa overlap); Q9RU92|DR1500 from
FT                   Deinococcus radiodurans (444 aa), FASTA scores: opt: 1445,
FT                   E(): 4.1e-84, (52.9% identity in 427 aa overlap); etc.
FT                   Contains respiratory-chain NADH dehydrogenase 51 Kd subunit
FT                   signature 2 (PS00645). BELONGS TO THE COMPLEX I 51 KDA
FT                   SUBUNIT FAMILY. COFACTOR: FMN AND ONE 4FE-4S CLUSTER
FT                   (PROBABLE). TBparse score is 0.889."
FT                   /db_xref="GOA:P65567"
FT                   /db_xref="InterPro:IPR019554"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65567"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06289.1"
FT                   /translation="MTTQATPLTPVISRHWDDPESWTLATYQRHDRYRGYQALQKALTM
FT                   PPDDVISIVKDSGLRGRGGAGFATGTKWSFIPQGDTGAAAKPHYLVVNADESEPGTCKD
FT                   IPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVVPVLRRLHNAVAEAYAAGFLGRNI
FT                   GGSGFDLELVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNV
FT                   ETIASVPSIILGGIDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAG
FT                   GVRAGHRLKFWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDETTCVVRA
FT                   VRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDISDSILGKSFC
FT                   ALGDGAASPVMSSIKHFRDEYLAHVEGGGCPFDPRDSMLVANGVDA"
FT   misc_feature    48799..48834
FT                   /note="PS00645 Respiratory-chain NADH dehydrogenase 51 Kd
FT                   subunit signature 2"
FT   CDS             49083..51503
FT                   /transl_table=11
FT                   /gene="nuoG"
FT                   /locus_tag="Rv3151"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN G) NUOG
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN G)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3151, (MTCY03A2.07c), len: 806 aa. Probable nuoG,
FT                   NADH dehydrogenase I, chain G (EC 1.6.5.3), similar to
FT                   others e.g. Q9XAR0|NUOG_STRCO from Streptomyces coelicolor
FT                   (843 aa), FASTA scores: opt: 1968 ,E(): 5.2e-107, (62.45%
FT                   identity in 818 aa overlap); P56914|NUG2_RHIME from
FT                   Rhizobium meliloti (853 aa), FASTA scores: opt: 964, E():
FT                   1.6e-48, (30.6% identity in 840 aa overlap); etc. But also
FT                   similarity with other proteins e.g. P77908|FDHA FORMATE
FT                   DEHYDROGENASE, ALPHA SUBUNIT (EC 1.2.1.43) (FORMATE
FT                   DEHYDROGENASE [NADP+]) from Moorella thermoacetica
FT                   (Clostridium thermoaceticum) (893 aa), FASTA scores: opt:
FT                   928, E(): 2e-46, (28.65% identity in 865 aa overlap); and
FT                   Q9UUU3|NUAM NUAM PROTEIN PRECURSOR (EC 1.6.99.3) from
FT                   Yarrowia lipolytica (Candida lipolytica) (728 aa), FASTA
FT                   scores: opt: 894, E(): 1.7e-44, (31.95% identity in 676 aa
FT                   overlap). Equivalent to AAK47578 from Mycobacterium
FT                   tuberculosis strain CDC1551 but longer 15 aa. Contains
FT                   respiratory-chain NADH dehydrogenase 75 kDa subunit
FT                   signature 2 (PS00642). BELONGS TO THE COMPLEX I 75 KDA
FT                   SUBUNIT FAMILY. COFACTOR: MAY BIND TWO 4FE-4S CLUSTER AND
FT                   ONE 2FE-2S CLUSTER. TBparse score is 0.887."
FT                   /db_xref="GOA:P95175"
FT                   /db_xref="InterPro:IPR019574"
FT                   /db_xref="UniProtKB/Swiss-Prot:P95175"
FT                   /protein_id="CAB06288.1"
FT                   /translation="MTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQI
FT                   PRFCDHPLLEPVGACRQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQHGVM
FT                   ELLLINHPLDCPMCDKGGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLDRER
FT                   CILCARCTRFSDQIAGDPFIDMQERGALQQVGIYADEPFESYFSGNTVQICPVGALTGT
FT                   AYRFRARPFDLVSSPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCDKGRWA
FT                   FTYATQPDVITTPLIRDGGDPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVGGRVTWE
FT                   DAYAYAKFARITLGTNDIDFRARPHSAEEADFLAARIAGRHMAVSYADLESAPVVLLVG
FT                   FEPEDESPIVFLRLRKAARRHRVPVYTIAPFATGGLHKMSGRLIKTVPGGEPAALDDLA
FT                   TGAVGDLLATPGAVIIVGERLATVPGGLSAAARLADTTGARLAWVPRRAGERGALEAGA
FT                   LPTLLPGGRPLADEVARAQVCAAWHIAELPAAAGRDADGILAAAADETLAALLVGGIEP
FT                   ADFADPDAVLAALDATGFVVSLELRHSTVTERADVVFPVAPTTQKAGAFVNWEGRYRTF
FT                   EPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGIWDGKHAAGPHIA
FT                   ATGPTQPEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSPDTAAEIGAADGEA
FT                   VTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGSIVKIGAGS"
FT   misc_feature    49425..49463
FT                   /note="PS00642 Respiratory-chain NADH dehydrogenase 75 Kd
FT                   subunit signature 2"
FT   CDS             51619..52851
FT                   /transl_table=11
FT                   /gene="nuoH"
FT                   /locus_tag="Rv3152"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN H) NUOH
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN H)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3152, (MTCY03A2.06c), len: 410 aa. Probable nuoH,
FT                   integral membrane NADH dehydrogenase I, chain H (EC
FT                   1.6.5.3), similar to others e.g. Q9XAR1 Q9XAR1|NUOH from
FT                   Streptomyces coelicolor (467 aa), FASTA scores: opt: 1630,
FT                   E(): 3.4e-90, (58.35% identity in 413 aa overlap);
FT                   Q9RU94|DR1498 from Deinococcus radiodurans (397 aa), FASTA
FT                   scores: opt: 1081, E(): 2e-57, (45.5% identity in 391 aa
FT                   overlap); Q9ZCF7|NUOH_RICPR|RP796 from Rickettsia
FT                   prowazekii (339 aa), FASTA scores: opt: 976, E(): 3.4e-51,
FT                   (46.2% identity in 329 aa overlap); etc. Contains
FT                   respiratory-chain NADH dehydrogenase subunit 1 signature 2
FT                   (PS00668). Some similarity to MTCY251.02 (FASTA score: E():
FT                   1.2e-07). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY."
FT                   /db_xref="GOA:P65561"
FT                   /db_xref="InterPro:IPR018086"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65561"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06287.1"
FT                   /translation="MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRP
FT                   GPNRVGPKGALQSLADGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFGPE
FT                   VSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISY
FT                   EVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLP
FT                   EAEGELVAGFHTEYSSLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANT
FT                   GWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVAAIIRSL
FT                   RNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPL
FT                   LAGATKENAGG"
FT   misc_feature    52270..52311
FT                   /note="PS00668 Respiratory-chain NADH dehydrogenase subunit
FT                   1 signature 2"
FT   CDS             52844..53479
FT                   /transl_table=11
FT                   /gene="nuoI"
FT                   /locus_tag="Rv3153"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN I) NUOI
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN I)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3153, (MTCY03A2.05c), len: 211 aa. Probable nuoI,
FT                   NADH dehydrogenase I, chain I (EC 1.6.5.3), similar to
FT                   others e.g. Q9XAR2|NUOI from Streptomyces coelicolor (211
FT                   aa), FASTA scores: opt: 825, E(): 9.3e-44, (70.1% identity
FT                   in 164 aa overlap); Q56224|NQO9_THETH from Thermus
FT                   aquaticus (subsp. thermophilus) (182 aa), FASTA scores:
FT                   opt: 543, E(): 1.8e-26, (50.9% identity in 163 aa overlap);
FT                   Q9RU95|DR1497 from Deinococcus radiodurans (178 aa), FASTA
FT                   scores: opt: 527, E(): 1.7e-25, (48.75% identity in 162 aa
FT                   overlap); etc. Contains two 4Fe-4S ferredoxins, iron-sulfur
FT                   binding region signatures (PS00198). BELONGS TO THE COMPLEX
FT                   I 23 KDA SUBUNIT FAMILY. THE IRON-SULFUR CENTERS ARE
FT                   SIMILAR TO THOSE OF 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS.
FT                   COFACTOR: BINDS TWO 4FE-4S CLUSTERS. TBparse score is
FT                   0.952."
FT                   /db_xref="GOA:P95173"
FT                   /db_xref="HSSP:1FCA"
FT                   /db_xref="InterPro:IPR010226"
FT                   /db_xref="UniProtKB/Swiss-Prot:P95173"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06286.1"
FT                   /translation="MANTDRPALPHKRAVPPSRADSGPRRRRTKLLDAVAGFGVTLGSM
FT                   FKKTVTEEYPERPGPVAARYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYVEGADNT
FT                   EEERFSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTYDYELADDNRADLIYEKDR
FT                   LLAPLLPEMAAPPHPRTPGATDKDYYLGNVTAEGLRGVRESQTTGDSR"
FT   misc_feature    53084..53119
FT                   /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding
FT                   region signature"
FT   misc_feature    53219..53254
FT                   /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding
FT                   region signature"
FT   CDS             53476..54264
FT                   /transl_table=11
FT                   /gene="nuoJ"
FT                   /locus_tag="Rv3154"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN J) NUOJ
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN J)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3154, (MTCY03A2.04c), len: 262 aa. Probable nuoJ,
FT                   transmembrane NADH dehydrogenase I, chain J (EC 1.6.5.3),
FT                   similar to others e.g. Q9XAR3|NUOJ from Streptomyces
FT                   coelicolor (285 aa), FASTA scores: opt: 991, E(): 3.2e-52,
FT                   (63.7% identity in 243 aa overlap); Q9JX90|NUOJ|NMA0006
FT                   from Neisseria meningitidis (serogroup A) (223 aa), FASTA
FT                   scores: opt: 329, E(): 9.6e-13, (34.85% identity in 175 aa
FT                   overlap); Q9K1B2|NMB0253 from Neisseria meningitidis
FT                   (serogroup B) (223 aa), FASTA scores: opt: 326, E():
FT                   1.5e-12, (34.85% identity in 175 aa overlap); etc. But also
FT                   similarity with Q00243|NU6C_PLEBO|NDH6 NADH-PLASTOQUINONE
FT                   OXIDOREDUCTASE CHAIN 6 HOMOLOG (EC 1.6.5.3) (CATALYTIC
FT                   ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL)
FT                   from Plectonema boryanum (199 aa), FASTA scores: opt: 287,
FT                   E(): 2.8e-10, (34.35% identity in 195 aa overlap). SIMILAR
FT                   TO POLYPEPTIDE 6 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF
FT                   CHLOROPLASTS OR MITOCHONDRIA. TBparse score is 0.890."
FT                   /db_xref="GOA:P95172"
FT                   /db_xref="InterPro:IPR001457"
FT                   /db_xref="UniProtKB/TrEMBL:P95172"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06285.1"
FT                   /translation="MTAVLASDVIVRTSTGEAVMFWVLSALALLGAVGVVLAVNAVYSA
FT                   MFLAMTMIILAVFYMAQDALFLGVVQVVVYTGAVMMLFLFVLMLIGVDSAESLKETLRG
FT                   QRVAAVLTGVGFGVLLISTIGQVATRGFAGLTVANANGNVEGLAALIFSRYLWAFELTS
FT                   ALLITAAVGAMVLAHRERFERRKTQRELSQERFRPGGHPTPLPNPGVYARHNAVDVAAL
FT                   LPDGSYSELSVPRMLRTRGADGLQTPSPGAVSGSLEGGAS"
FT   CDS             54261..54560
FT                   /transl_table=11
FT                   /gene="nuoK"
FT                   /locus_tag="Rv3155"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN K) NUOK
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN K)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3155, (MTCY03A2.03c), len: 99 aa. Probable nuoK,
FT                   integral membrane NADH dehydrogenase I, chain K (EC
FT                   1.6.5.3), similar to others e.g. Q9XAR4|NUOK from
FT                   Streptomyces coelicolor (99 aa), FASTA scores: opt: 509,
FT                   E(): 2.7e-31, (78.55% identity in 98 aa overlap);
FT                   Q56226|NQOB_THETH|NQO11 from Thermus aquaticus (subsp.
FT                   thermophilus) (95 aa), BLAST scores: initn: 298, init1:
FT                   180, bits: 85.7, FASTA scores: opt: 313, E(): 9.4e-17,
FT                   (53.7% identity in 95 aa overlap); Q9RU97|DR1495 from
FT                   Deinococcus radiodurans (103 aa), FASTA scores: opt: 309,
FT                   E(): 2e-16, (52.0% identity in 100 aa overlap); etc. But
FT                   also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES
FT                   CHAIN 4L e.g. Q9MUL4|NULC_MESVI|NDHE from Mesostigma viride
FT                   (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE =
FT                   NAD(+) + PLASTOQUINOL) (101 aa), FASTA scores: opt: 280,
FT                   E(): 2.8e-14, (40.6% identity in 101 aa overlap); and
FT                   P06261|NULC_TOBAC|NDHE|NDH4L from Nicotiana tabacum (Common
FT                   tobacco) (101 aa), FASTA scores: opt: 259, E(): 1e-12,
FT                   (43.0% identity in 93 aa overlap). SIMILAR TO POLYPEPTIDE
FT                   4L OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR
FT                   MITOCHONDRIA. TBparse score is 0.897."
FT                   /db_xref="GOA:P65565"
FT                   /db_xref="InterPro:IPR001133"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65565"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06284.1"
FT                   /translation="MNPANYLYLSVLLFTIGASGVLLRRNAIVMFMCVELMLNAVNLAF
FT                   VTFARMHGHLDAQMIAFFTMVVAACEVVVGLAIIMTIFRTRKSASVDDANLLKG"
FT   CDS             54571..56472
FT                   /transl_table=11
FT                   /gene="nuoL"
FT                   /locus_tag="Rv3156"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN L) NUOL
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN L)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3156, (MTCY03A2.02c), len: 633 aa. Probable nuoL,
FT                   integral membrane NADH dehydrogenase I, chain L (EC
FT                   1.6.5.3), similar to others e.g. Q9XAR5|NUOL_STRCO from
FT                   Streptomyces coelicolor (654 aa), FASTA scores: opt: 2074,
FT                   E(): 1.1e-111, (61.1% identity in 648 aa overlap);
FT                   Q56227|NQOC_THETH|NQO12 from Thermus aquaticus (subsp.
FT                   thermophilus) (606 aa), FASTA scores: opt: 1420, E():
FT                   3.8e-74, (43.35% identity in 630 aa overlap);
FT                   Q9ZJV6|NUOL|JHP1192 from Helicobacter pylori J99
FT                   (Campylobacter pylori J99) (612 aa), FASTA scores: opt:
FT                   1279, E(): 4.7e-66, (41.65% identity in 516 aa overlap);
FT                   etc. Also similar to MTCY251.04 (FASTA score: E(): 1.3e-11)
FT                   and MTCY03A2.01c (FASTA score: E(): 2.3e-10). SIMILAR TO
FT                   POLYPEPTIDE 5 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF
FT                   CHLOROPLASTS OR MITOCHONDRIAL. TBparse score is 0.892."
FT                   /db_xref="GOA:O86350"
FT                   /db_xref="InterPro:IPR018393"
FT                   /db_xref="UniProtKB/Swiss-Prot:O86350"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA16667.1"
FT                   /translation="MTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALA
FT                   AFGVGAMLLADMLGRDGLERAIHQQVFTWIPAGGLQVDFGLQIDQLSMCFVLLISGVGS
FT                   LIHIYSVGYMAEDPDRRRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLLIGF
FT                   WYHKPSAATAAKKAFVMNRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAI
FT                   GLLMLLGACAKSAQVPLQAWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAP
FT                   TAQLAVVIVGAVTLLFGAIIGCAKDDIKRALAASTISQIGYMVLAAGLGPAGYAFAIMH
FT                   LLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFA
FT                   GFFSKDAIIEAALGAGGIRGSLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPH
FT                   EAPAVMTWPMILLAVGSVFSGGLLAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALG
FT                   VVAVGIAVAYRMYGTAPIPRVAPVRVSALTAAARADLYGDAFNEEVFMRPGAQLTNAVV
FT                   AVDDAGVDGSVNALATLVSQTSNRLRQMQTGFARNYALSMLVGAVLVAAALLVVQLW"
FT   CDS             56469..58130
FT                   /transl_table=11
FT                   /gene="nuoM"
FT                   /locus_tag="Rv3157"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN M) NUOK
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN M)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3157, (MTCY03A2.01c-MTV014.01c), len: 553 aa.
FT                   Probable nuoM, integral membrane NADH dehydrogenase I,
FT                   chain M (EC 1.6.5.3), similar to others e.g. Q9XAR6|NUOM
FT                   from Streptomyces coelicolor (523 aa), FASTA scores: opt:
FT                   1621, E(): 4.2e-89, (56.55% identity in 541 aa overlap);
FT                   P50974|NUOM_RHOCA|NUOM from Rhodobacter capsulatus
FT                   (Rhodopseudomonas capsulata) (512 aa), FASTA scores: opt:
FT                   996, E(): 6.5e-52, (38.2% identity in 521 aa overlap);
FT                   P29925|NQOD_PARDE|NQO13 from Paracoccus denitrificans (513
FT                   aa), FASTA scores: opt: 987, E(): 2.2e-51, (37.05% identity
FT                   in 540 aa overlap); etc. Also similar to MTCY251.04 (FASTA
FT                   score: E(): 3.3e-16) and MTCY03A2.02c (FASTA score: E():
FT                   9.6e-13). SIMILAR TO POLYPEPTIDE 4 OF THE NADH-UBIQUINOL
FT                   OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIAL. TBparse
FT                   score is 0.883."
FT                   /db_xref="GOA:O53307"
FT                   /db_xref="InterPro:IPR001750"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53307"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA16668.1"
FT                   /translation="MNNVPWLSVLWLVPLAGAVLIILLPPGRRRLAKWAGMVVSVLTLA
FT                   VSIVVAAEFKPSAEPYQFVEKHSWIPAFGAGYTLGVDGIAVVLVLLTTVLIPLLLVAGW
FT                   NDATDADDLSPASGRYPQRPAPPRLRSSGGERTRGVHAYVALTLAIESMVLMSVIALDV
FT                   LLFYVFFEAMLIPMYFLIGGFGQGAGRSRAAVKFLLYNLFGGLIMLAAVIGLYVVTAQY
FT                   DSGTFDFREIVAGVAAGRYGADPAVFKALFLGFMFAFAIKAPLWPFHRWLPDAAVESTP
FT                   ATAVLMMAVMDKVGTFGMLRYCLQLFPDPSTYFRPLIVTLAIIGVIYGAIVAIGQTDMM
FT                   RLIAYTSISHFGFIIAGIFVMTTQGQSGSTLYMLNHGLSTAAVFLIAGFLIARRGSRSI
FT                   ADYGGVQKVAPILAGTFMVSAMATVSLPGLAPFISEFLVLLGTFSRYWLAAAFGVTALV
FT                   LSAVYMLWLYQRVMTGPVAEGNERIGDLVGREMIVVAPLIALLLVLGVYPKPVLDIINP
FT                   AVENTMTTIGQHDPAPSVAHPVPAVGASRTAEGPHP"
FT   CDS             58127..59722
FT                   /transl_table=11
FT                   /gene="nuoN"
FT                   /locus_tag="Rv3158"
FT                   /product="PROBABLE NADH DEHYDROGENASE I (CHAIN N) NUON
FT                   (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN N)"
FT                   /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION
FT                   [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) +
FT                   UBIQUINOL]."
FT                   /EC_number="1.6.5.3"
FT                   /note="Rv3158, (MTV014.02c), len: 531 aa. Probable nuoN,
FT                   integral membrane NADH dehydrogenase I, chain N (EC
FT                   1.6.5.3), similar to others e.g. Q9XAR7|SC10A7.08c from
FT                   Streptomyces coelicolor (552 aa), FASTA scores: opt: 1493,
FT                   E(): 1.1e-81, (56.7% identity in 543 aa overlap);
FT                   Q9PGI2|XF0318 from Xylella fastidiosa (485 aa), FASTA
FT                   scores: opt: 942, E(): 7.4e-49, (39.6% identity in 379 aa
FT                   overlap); CAB51628|NUON2 from Rhizobium meliloti
FT                   (Sinorhizobium meliloti) (479 aa), FASTA scores: opt: 934,
FT                   E(): 2.2e-48, (35.5% identity in 479 aa overlap); etc. But
FT                   also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES
FT                   CHAIN 4L (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH +
FT                   PLASTOQUINONE = NAD(+) + PLASTOQUINOL) e.g.
FT                   P29801|NU2C_SYNP7|NDHB from Synechococcus sp. strain PCC
FT                   7942 (Anacystis nidulans R2) (521 aa), FASTA scores: opt:
FT                   921, E(): 1.4e-47, (40.25% identity in 395 aa overlap).
FT                   BELONGS TO THE COMPLEX I SUBUNIT 2 FAMILY. TBparse score is
FT                   0.901."
FT                   /db_xref="GOA:P0A5M0"
FT                   /db_xref="InterPro:IPR001750"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5M0"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA16623.1"
FT                   /translation="MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTL
FT                   ALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERS
FT                   ARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSVGGM
FT                   MVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGV
FT                   ALLYGATGTLTLPGIRDALAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGA
FT                   PTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTN
FT                   VKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSA
FT                   GSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLV
FT                   IVGVISSGVAAYFYVRVIVSMFFTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQ
FT                   PVLDLADQAAQLLR"
FT   CDS             complement(59728..61500)
FT                   /transl_table=11
FT                   /gene="PPE53"
FT                   /locus_tag="Rv3159c"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3159c, (MTV014.03c), len: 590 aa. Member of the
FT                   Mycobacterium tuberculosis PPE_family of Gly-, Asn-rich
FT                   proteins. Highly similar to P71868|Rv3533c|MTCY03C7.23 (582
FT                   aa), FASTA scores: opt: 2289, E(): 3.2e-98, (63.5% identity
FT                   in 600 aa overlap); and also similar to MTCY48_17,
FT                   MTV041_29, MTCY6G11_5, MTCY98_24, etc. TBparse score is
FT                   0.921."
FT                   /db_xref="InterPro:IPR002989"
FT                   /db_xref="UniProtKB/TrEMBL:Q6MX04"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55561.1"
FT                   /translation="MNYSVLPPEINSLRMFTGAGSAPMLAASVAWDRLAAELAVAASSF
FT                   GSVTSGLAGQSWQGAAAAAMAAAAAPYAGWLAAAAARAAGASAQAKAVASAFEAARAAT
FT                   VHPMLVAANRNAFVQLVLSNLFGQNAPAIAAAEAMYEQMWAADVAAMVGYHGGASAAAA
FT                   QLSSWSIGLQQALPAAPSALAAAIGLGNIGVGNLGGGNTGDYNLGSGNSGNANVGSGNS
FT                   GNANVGSGNDGATNLGSGNIGNTNLGSGNVGNVNLGSGNRGFGNLGNGNFGSGNLGSGN
FT                   TGSTNFGGGNLGSFNLGSGNIGSSNIGFGNNGDNNLGLGNNGNNNIGFGLTGDNLVGIG
FT                   ALNSGIGNLGFGNSGNNNIGFFNSGNNNVGFFNSGNNNFGFGNAGDINTGFGNAGDTNT
FT                   GFGNAGFFNMGIGNAGNEDMGVGNGGSFNVGVGNAGNQSVGFGNAGTLNVGFANAGSIN
FT                   TGFANSGSINTGGFDSGDRNTGFGSSVDQSVSSSGFGNTGMNSSGFFNTGNVSAGYGNN
FT                   GDVQSGINNTNSGGFNVGFYNSGAGTVGIANSGLQTTGIANSGTLNTGVANTGDHSSGG
FT                   FNQGSDQSGFFGQP"
FT   CDS             complement(61675..62316)
FT                   /transl_table=11
FT                   /locus_tag="Rv3160c"
FT                   /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   (PROBABLY TETR-FAMILY)"
FT                   /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv3160c, (MTV014.04c), len: 213 aa. Possible
FT                   transcriptional regulator, with some similarity to others
FT                   e.g. Q9S3L4|AMTR AMTR PROTEIN (global repressor in the
FT                   nitrogen regulation system; see Jakoby et al., 2000) (222
FT                   aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity
FT                   in 208 aa overlap); Q9X7X9|SC6A5.33c PUTATIVE REGULATORY
FT                   PROTEIN from Streptomyces coelicolor (223 aa), FASTA
FT                   scores: opt: 176, E(): 0.00018, (26.5% identity in 185 aa
FT                   overlap); Q9XA31|SCH69.03c PUTATIVE TRANSCRIPTIONAL
FT                   REGULATOR from Streptomyces coelicolor (209 aa), FASTA
FT                   scores: opt: 173, E(): 0.00027, (27.25% identity in 176 aa
FT                   overlap); BAB54133|MLL7734 TRANSCRIPTIONAL REGULATOR from
FT                   Rhizobium loti (Mesorhizobium loti) (213 aa), FASTA scores:
FT                   opt: 172, E(): 0.00031, (23.55% identity in 204 aa
FT                   overlap); etc. Also similar to hypothetical proteins from
FT                   Mycobacterium tuberculosis strain H37Rv e.g.
FT                   P96839|Rv3557v|MTCY06G11.04c (200 aa), FASTA scores: opt:
FT                   169, E(): 0.00046, (26.75% identity in 157 aa overlap).
FT                   Contains probable helix-turn-helix motif from aa 31 to 52
FT                   (Score 1857, +5.51 SD). SIMILAR TO THE TETR/ACRR FAMILY OF
FT                   TRANSCRIPTIONAL REGULATORS. TBparse score is 0.901."
FT                   /db_xref="GOA:O53310"
FT                   /db_xref="InterPro:IPR012287"
FT                   /db_xref="UniProtKB/TrEMBL:O53310"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA16625.1"
FT                   /translation="MPRQAGRWSPTALRILGAAAELIALRGYSSTSTRDIAAAVGVEQP
FT                   AIYKHFSAKRDILAALVRLAVEWPLELFGHITAMPVPAVVKLHRWLTESLDHLHASPYV
FT                   LVSILITPDLHQESFVAERELVAEMERALVGLIETGQGEGDVRAMHPLSAARLVQALFD
FT                   ALALPEFAVSPDEIVEFAMTALLSDPDRLAEIRAAADALEIQTAPPDRGL"
FT   CDS             complement(62327..63475)
FT                   /transl_table=11
FT                   /locus_tag="Rv3161c"
FT                   /product="POSSIBLE DIOXYGENASE"
FT                   /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv3161c, (MTV014.05c), len: 382 aa. Possible
FT                   dioxygenase (EC 1.-.-.-), similar to subunit of several
FT                   dioxygenases and related proteins e.g. BAB50510|MLR3662
FT                   DIOXYGENASE, ALPHA SUBUNIT from Rhizobium loti
FT                   (Mesorhizobium loti) (400 aa), FASTA scores: opt: 413, E():
FT                   6.2e-20, (28.4% identity in 331 aa overlap); Q9A3T0|CC3122
FT                   RIESKE 2FE-2S FAMILY PROTEIN from Caulobacter crescentus
FT                   (404 aa), FASTA scores: opt: 405, E(): 2.1e-19, (27.95%
FT                   identity in 372 aa overlap); Q9HTF4|PA5410 PROBABLE RING
FT                   HYDROXYLATING DIOXYGENASE, ALPHA-SUBUNIT from Pseudomonas
FT                   aeruginosa (429 aa), FASTA scores: opt: 392, E(): 1.6e-18,
FT                   (25.8% identity in 399 aa overlap); Q9AGK6|PHTAA PHTHALATE
FT                   DIOXYGENASE LARGE SUBUNIT from Arthrobacter keyseri (473
FT                   aa), FASTA scores: opt: 385, E(): 5.2e-18, (34.0% identity
FT                   in 206 aa overlap); P76253|YEAW_ECOLI PUTATIVE DIOXYGENASE,
FT                   ALPHA SUBUNIT from Escherichia coli (374 aa), FASTA scores:
FT                   opt: 376, E(): 1.7e-17, (27.05% identity in 344 aa
FT                   overlap); etc. TBparse score is 0.932."
FT                   /db_xref="GOA:O53311"
FT                   /db_xref="InterPro:IPR017941"
FT                   /db_xref="UniProtKB/TrEMBL:O53311"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA16626.1"
FT                   /translation="MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQLER
FT                   ERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLHALSPICRHRLMLMVE
FT                   PGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDFNRRECRLPQFAVATWNGLVWINL
FT                   DADAEPIAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHENYHVLGLHRQ
FT                   TLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKSNLVVLWTFPNSALA
FT                   IAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDEDRLGLEA
FT                   VQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS"
FT   CDS             complement(63545..63982)
FT                   /transl_table=11
FT                   /locus_tag="Rv3162c"
FT                   /product="POSSIBLE INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3162c, (MTV014.06c), len: 145 aa. Possible
FT                   integral membrane protein, with some similarity to
FT                   C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical
FT                   protein from Mycobacterium tuberculosis (287 aa), FASTA
FT                   scores: opt: 112, E(): 6.9, (29.65% identity in 135 aa
FT                   overlap); and other hypothetical proteins from other
FT                   organisms. TBparse score is 0.924."
FT                   /db_xref="UniProtKB/TrEMBL:O53312"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA16627.1"
FT                   /translation="MTSFAHPGTRGLSTVFGLMMVGSAAVGSHGLAVVVGLAAVIAVGV
FT                   AAVFRLAATLAVVLSVVMIVVSGPTHVLAALSGFCAAVYLVCRYGAGVVAGSWPTTVAA
FT                   VGFTFAGLAATSFPLQVPWLPLAAPLAVLATYVLATRPFSR"
FT   CDS             complement(63979..65250)
FT                   /transl_table=11
FT                   /locus_tag="Rv3163c"
FT                   /product="POSSIBLE CONSERVED SECRETED PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3163c, (MTV014.07c), len: 423 aa. Possible
FT                   conserved secreted protein, with some similarity to other
FT                   hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from
FT                   Streptomyces coelicolor (460 aa), FASTA scores: opt: 666,
FT                   E(): 1.5e-33, (33.55% identity in 417 aa overlap);
FT                   O58486|PH0774 from Pyrococcus horikoshii (410 aa), FASTA
FT                   scores: opt: 329, E(): 6.9e-13, (23.8% identity in 424 aa
FT                   overlap); Q9UZ66|PAB0849 from Pyrococcus abyssi (410 aa),
FT                   FASTA scores: opt: 322, E(): 1.9e-12, (24.15% identity in
FT                   389 aa overlap); etc. Also some similarity with
FT                   P71761|Rv1480|MTV007.27|MTCY277.01 from Mycobacterium
FT                   tuberculosis (317 aa), FASTA scores: opt: 198, E():
FT                   6.3e-05, (26.75% identity in 269 aa overlap). Contains
FT                   PS00402 Binding-protein-dependent transport systems inner
FT                   membrane comp signature."
FT                   /db_xref="InterPro:IPR002881"
FT                   /db_xref="UniProtKB/TrEMBL:O53313"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA16628.1"
FT                   /translation="MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAAP
FT                   LLGVLCSISWQRPVPVIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALAGM
FT                   QFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPLTPP
FT                   QSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTRR
FT                   LTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGGNRPRW
FT                   LGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTEFALALI
FT                   DLRKRGHVVVAVDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSL
FT                   QQSMGALPNRRRRGRGRASRARLP"
FT   misc_feature    complement(64774..64860)
FT                   /note="PS00402 Binding-protein-dependent transport systems
FT                   inner membrane comp signature"
FT   CDS             complement(65280..66242)
FT                   /transl_table=11
FT                   /gene="moxR3"
FT                   /locus_tag="Rv3164c"
FT                   /product="PROBABLE METHANOL DEHYDROGENASE TRANSCRIPTIONAL
FT                   REGULATORY PROTEIN MOXR3"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM; REGULATES
FT                   METHANOL DEHYDROGENASE."
FT                   /note="Rv3164c, (MTV014.08c), len: 320 aa. Probable moxR3,
FT                   methanol dehydrogenase regulatory protein, highly similar
FT                   to Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from
FT                   Streptomyces coelicolor (332 aa), FASTA scores: opt: 1227,
FT                   E(): 1.7e-67, (60.25% identity in 302 aa overlap);
FT                   Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY
FT                   PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt:
FT                   1126, E(): 2.3e-61, (54.1% identity in 305 aa overlap);
FT                   Q9HSH7|MOXR|VNG0223G METHANOL DEHYDROGENASE REGULATORY
FT                   PROTEIN from Halobacterium sp. strain NRC-1 (318 aa), FASTA
FT                   scores: opt: 1072, E(): 4.5e-58, (51.45% identity in 315 aa
FT                   overlap); Q9RVV4|DR0918 MOXR-RELATED PROTEIN from
FT                   Deinococcus radiodurans (354 aa), FASTA scores: opt: 1000,
FT                   E(): 1.2e-53, (50.95% identity in 318 aa overlap); etc.
FT                   Also high similarity with several hypothetical bacterial
FT                   proteins. TBparse score is 0.917."
FT                   /db_xref="GOA:O53314"
FT                   /db_xref="InterPro:IPR016366"
FT                   /db_xref="UniProtKB/TrEMBL:O53314"
FT                   /protein_id="CAA16629.1"
FT                   /translation="MIMPAATTTAHCEAVLDEIERVVVGKRSALTLILTAVLARGHVLI
FT                   EDLPGLGKTLIARSFAAALGLDFTRVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFT
FT                   NLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTYPLP
FT                   EAQLDRFAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVEQVTV
FT                   HEDVLHYVVSLANATRHHPQVAVGASPRAELDLVQLSRARALLLGRDYVIPEDVKELAT
FT                   AAVAHRITLRPEMWVRKIAGADVVSELLRRLPVPRISGT"
FT   CDS             complement(66250..66732)
FT                   /transl_table=11
FT                   /locus_tag="Rv3165c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3165c, (MTV014.09)c, len: 160 aa. Hypothetical
FT                   unknown protein. TBparse score is 0.928."
FT                   /db_xref="UniProtKB/TrEMBL:O53315"
FT                   /protein_id="CAA16630.1"
FT                   /translation="MKRLIALGIFLIVGIELLALILHDRRLVLAGSGLALALVLLNVRR
FT                   MLGNRDELTAAPDSDDLGEGLRRWLSNTETTIRWSESTRADWDRHLRPMLARRFEIATG
FT                   HRQAKDPVAFAATGRMLFGDELWEWVNPNNVTHTGDRQPGPGRAALEEILQKLEQV"
FT   CDS             complement(66729..67688)
FT                   /transl_table=11
FT                   /locus_tag="Rv3166c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3166c, (MTV014.10c), len: 319 aa. Probable
FT                   transmembrane protein, similar but longer (52 aa) to
FT                   O32895|MLCB1779.35c hypothetical protein from Mycobacterium
FT                   leprae (119 aa), FASTA scores: opt: 289, E(): 3.7e-10,
FT                   (44.25% identity in 122 aa overlap). Also some similarity
FT                   to Q9Z536|SC9B2.23c PUTATIVE TRANSMEMBRANE PROTEIN from
FT                   Streptomyces coelicolor (339 aa), FASTA scores: opt: 247,
FT                   E(): 2.5e-07, (28.2% identity in 326 aa overlap); and in
FT                   N-terminus to Q9RS20|DR2307 PUTATIVE MULTIDRUG-EFFLUX
FT                   TRANSPORTER from Deinococcus radiodurans (410 aa), FASTA
FT                   scores: opt: 135,E(): 1, (32.35% identity in 136 aa
FT                   overlap). TBparse score is 0.934."
FT                   /db_xref="UniProtKB/TrEMBL:O53316"
FT                   /protein_id="CAA16631.1"
FT                   /translation="MPGTKPGSDKPTGRVVVVIVLLMLAGAALRGHLPADDGAPLAAAG
FT                   GSRAALMFIVAALAATLALIALAIITRLRHPLPVAPSAGELSAMLGGAAGRPNWRVLLL
FT                   GLGTILAWLLIAILLARLFVPDDVGPAAPIPDSTATPDASSTTPSRPQPPQDNNDDVLG
FT                   ILFASTIGLFLMVVAGSLITSRRQRKSAPARISGDRIESPAPSARSESLARAAEIGLAE
FT                   MADLRREPREAIIACYVAMERELSHVPGVAPQDFDTPTEVLARAVEHRALHGASAAALV
FT                   SLFAEARFSPHVMNEEHREVAMRLLRLVLDELSTRTAI"
FT   CDS             complement(67768..68394)
FT                   /transl_table=11
FT                   /locus_tag="Rv3167c"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   (PROBABLY TETR-FAMILY)"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv3167c, (MTV014.11c), len: 208 aa. Probable
FT                   transcriptional regulator, tetR family, similar to several
FT                   transcriptional regulators e.g. Q9L2A4|SC8F4.22c (TETR/ACRR
FT                   FAMILY) from Streptomyces coelicolor (234 aa), FASTA
FT                   scores: opt: 317, E(): 7.5e-13, (33.35% identity in 210 aa
FT                   overlap); Q9RK47|SCF12.11 (TETR/ACRR FAMILY) from
FT                   Streptomyces coelicolor (206 aa), FASTA scores: opt: 293,
FT                   E(): 2.1e-11, (32.65% identity in 199 aa overlap); Q54288
FT                   REGULATOR OF ANTIBIOTIC TRANSPORT COMPLEXES (TETR/ACRR
FT                   FAMILY) (204 aa), FASTA scores: opt: 260, E(): 2.4e-09,
FT                   (30.75% identity in 205 aa overlap); etc. Equivalent to
FT                   AAK47595 from Mycobacterium tuberculosis strain CDC1551 but
FT                   shorter 21 aa. Contains probable helix-turn-helix motif
FT                   from aa 42 to 63 (Score 1727, +5.07 SD). MAY BE BELONG TO
FT                   THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse
FT                   score is 0.871."
FT                   /db_xref="GOA:O53317"
FT                   /db_xref="InterPro:IPR012287"
FT                   /db_xref="UniProtKB/TrEMBL:O53317"
FT                   /protein_id="CAA16632.1"
FT                   /translation="MKADLPSLDKAPGAGRPRDPRIDSAILSATAELLVQIGYSNLSLA
FT                   AVAERAGTTKSALYRRWSSKAELVHEAAFPAAPTALQAAAGDIAADIRMMIAATRDVFT
FT                   TPVVRAALPGLVADMTADAELNARVLARFADLFAAVRMRLREAVDRGEAHPDVDPDRLI
FT                   ELIGGATMLRMLLYPDDMLDDAWVDQTTAIVVRGVHRAAPGGSVV"
FT   CDS             68439..69575
FT                   /transl_table=11
FT                   /locus_tag="Rv3168"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3168, (MTV014.12), len: 378 aa. Conserved
FT                   hypothetical protein, similar to other hypothetical
FT                   proteins e.g. Q9M7Y6|F3E22.6 from Arabidopsis thaliana
FT                   (Mouse-ear cress) (314 aa), FASTA scores: opt: 236, E():
FT                   1.1e-07, (27.35% identity in 234 aa overlap);
FT                   Q9RYW2|DRA0194 from Deinococcus radiodurans (386 aa), FASTA
FT                   scores: opt: 207, E(): 9.1e-06, (23.45% identity in 320 aa
FT                   overlap); etc. Also some similarity with
FT                   O69727|Rc3761c|MTV025.109c HYPOTHETICAL PROTEIN from
FT                   Mycobacterium tuberculosis (351 aa), FASTA scores: opt:
FT                   193, E(): 6.4e-05, (29.4% identity in 242 aa overlap).
FT                   TBparse score is 0.907."
FT                   /db_xref="InterPro:IPR002575"
FT                   /db_xref="UniProtKB/TrEMBL:O53318"
FT                   /protein_id="CAA16633.1"
FT                   /translation="MANEPAIGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAPEVTV
FT                   ESGVDSTGMSSETIILTARWQQDGRSIQQKLVARVAPAAEDVPVFPTYRLDHQFEVIRL
FT                   VGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAERQR
FT                   QLQDATVAALATLHSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIGRSPL
FT                   LERTFEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWEMVALGPRELDVA
FT                   WMIFAHRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVMWACV
FT                   FMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH"
FT   CDS             69575..70699
FT                   /transl_table=11
FT                   /locus_tag="Rv3169"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3169, (MTV014.13), len: 374 aa. Conserved
FT                   hypothetical protein, with similarity to other hypothetical
FT                   proteins: Q9A8W6|CC1232 from Caulobacter crescentus (368
FT                   aa), FASTA scores: opt: 669, E(): 3.3e-34, (34.05% identity
FT                   in 376 aa overlap); and O32901|MLCB1779.41 from
FT                   Mycobacterium leprae (127 aa), FASTA scores: opt: 179, E():
FT                   0.00034, (29.0% identity in 131 aa overlap). Also weak
FT                   similarity with P95149|Rv1866|MTCY359.07c (804 aa), FASTA
FT                   scores: opt: 121, E(): 6.4, (37.0% identity in 119 aa
FT                   overlap). Equivalent to AAK47597 from Mycobacterium
FT                   tuberculosis strain CDC1551 but shorter 43 aa. TBparse
FT                   score is 0.890."
FT                   /db_xref="UniProtKB/TrEMBL:O53319"
FT                   /protein_id="CAA16634.1"
FT                   /translation="MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGNI
FT                   FLITGIGYYPNLGVKDAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLRKL
FT                   RIVLDETEGVAADLTWEGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVDGER
FT                   IAVDPATWLGSRDRSWGIRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLIIQEE
FT                   PDGFRSLNDCTRIWRDGHVEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVHFDVES
FT                   KLAVPTHVGGGYGGDSDWSHGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHVGRALCR
FT                   DGDGNPVQGWGLFEHGALGRHDPSGFADWSTLAP"
FT   misc_feature    70839..70859
FT                   /note="PS00092 N-6 Adenine-specific DNA methylases
FT                   signature"
FT   CDS             70842..72188
FT                   /transl_table=11
FT                   /gene="aofH"
FT                   /locus_tag="Rv3170"
FT                   /product="PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH
FT                   (AMINE OXIDASE) (MAO)"
FT                   /function="POSSIBLY CATALYZES THE OXIDATIVE DEAMINATION:
FT                   OXIDIZE ON PRIMARY AMINES, AND PERHAPS ON SECONDARY AND
FT                   TERTIARY AMINES [CATALYTIC ACTIVITY: RCH(2)NH(2) + H(2)O +
FT                   O(2) = RCHO + NH(3) + H(2)O(2)]. MUST HAVE IMPORTANT
FT                   FUNCTION IN METABOLISM. SUPPOSED INVOLVED IN
FT                   STATIONARY-PHASE SURVIVAL."
FT                   /EC_number="1.4.3.4"
FT                   /note="Rv3170, (MT3259, MTV014.14), len: 448 aa. Probable
FT                   aofH, flavin-containing (mono)amine oxidase (EC 1.4.3.4),
FT                   equivalent to a predicted homologous protein from
FT                   Mycobacterium smegmatis (see citation below), and similar
FT                   to many eukaryotic monoamine oxidases e.g. P49253|AOF_ONCMY
FT                   from Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
FT                   (522 aa), FASTA scores: opt: 869, E(): 5.3e-44, (37.7%
FT                   identity in 448 aa overlap); P21396|AOFA_RAT|MAOA from
FT                   Rattus norvegicus (Rat) (526 aa), FASTA scores: opt: 839,
FT                   E(): 3.2e-42, (37.45% identity in 446 aa overlap);
FT                   Q99NA8|MAO-A from Cavia porcellus (Guinea pig) (506 aa),
FT                   FASTA scores: opt: 836, E(): 4.6e-42, (37.0% identity in
FT                   446 aa overlap); P21398|AOFA_BOVIN from Bos taurus (Bovine)
FT                   (527 aa), FASTA scores: opt: 806, E(): 2.8e-40, (37.0%
FT                   identity in 446 aa overlap); P21397|AOFA_HUMAN (527 aa),
FT                   FASTA scores: opt: 801, E(): 5.6e-40, (37.2% identity in
FT                   446 aa overlap); etc. Alternative start possible at
FT                   position 3538487. BELONGS TO THE FLAVIN MONOAMINE OXIDASE
FT                   FAMILY. COFACTOR: FAD (POTENTIAL). TBparse score is 0.900."
FT                   /db_xref="GOA:P63533"
FT                   /db_xref="HSSP:1GOS"
FT                   /db_xref="InterPro:IPR002937"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63533"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA16635.1"
FT                   /translation="MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGR
FT                   SLTGRVAGVPADMGGSFIGPTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGT
FT                   IPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATSSSR
FT                   NLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQDRVPGGTQQIAQAA
FT                   AAQLGARVLLNAAVRRIDRHGAGVTVTSDQGQAEAGFVIVAIPPAHRVAIEFDPPLPPE
FT                   YQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFITFDVSPHADGPGILMG
FT                   FVDARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPG
FT                   SWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAAAEVAALL"
FT   CDS             complement(72183..73082)
FT                   /transl_table=11
FT                   /gene="hpx"
FT                   /locus_tag="Rv3171c"
FT                   /product="POSSIBLE NON-HEME HALOPEROXIDASE HPX"
FT                   /function="SUPPOSED INVOLVED IN DETOXIFICATION REACTIONS."
FT                   /EC_number="1.11.1.-"
FT                   /note="Rv3171c, (MTV014.15c), len: 299 aa. Possible hpx,
FT                   non-heme haloperoxidase (EC 1.11.1.-), similar to other
FT                   hydrolases (principaly epoxide hydrolases) and non-heme
FT                   chloroperoxidases e.g. Q9RKB6|SCE87.22c PUTATIVE HYDROLASE
FT                   from Streptomyces coelicolor (314 aa), FASTA scores: opt:
FT                   431, E(): 6e-20, (38.05% identity in 297 aa overlap);
FT                   Q9HZ14|PA3226 PROBABLE HYDROLASE (SIMILAR TO ALPHA/BETA
FT                   HYDROLASE FOLD) from Pseudomonas aeruginosa (275 aa), FASTA
FT                   scores: opt: 236, E(): 1e-07, (29.6% identity in 277 aa
FT                   overlap); Q9DBL9|1300003 D03RIK PROTEIN SIMILAR TO
FT                   ALPHA/BETA HYDROLASE FOLD from Mus musculus (Mouse) (351
FT                   aa), FASTA scores: opt: 223, E(): 8.3e-07, (24.35% identity
FT                   in 304 aa overlap); AAK46260|MT1988 EPOXIDE HYDROLASE from
FT                   Mycobacterium tuberculosis strain CDC1551 (356 aa), FASTA
FT                   scores: opt: 223, E(): 8.4e-07, (40.7% identity in 113 aa
FT                   overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME
FT                   CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) from
FT                   Streptomyces lividans (275 aa), FASTA scores: opt: 220,
FT                   E(): 1e-06, (29.5% identity in 305 aa overlap); etc.
FT                   Equivalent to AAK47599 Hydrolase, alpha/beta hydrolase
FT                   family from Mycobacterium tuberculosis strain CDC1551 but
FT                   shorter 24 aa. Start chosen by similarity, alternative with
FT                   good RBS possible. TBparse score is 0.907."
FT                   /db_xref="GOA:O53321"
FT                   /db_xref="InterPro:IPR000073"
FT                   /db_xref="UniProtKB/TrEMBL:O53321"
FT                   /protein_id="CAA16636.1"
FT                   /translation="MTVRAADGTPLHTQVFGPPHGYPIVLTHGFVCAIRAWAYQIADLA
FT                   GDYRVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAGHSMGGITI
FT                   AAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELSPVRVLAGRSLVNTFGGF
FT                   PLPGAARALSRHVISTLAVAADADPSATRLVYELFTQTSAAGRGGCAKMLVEEVGSAHL
FT                   NLDGLTVPTLVIGGVRDRLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHL
FT                   RALAESVTRHVRDRRISS"
FT   CDS             complement(73219..73701)
FT                   /transl_table=11
FT                   /locus_tag="Rv3172c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3172c, (MTV014.16c), len: 160 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O53322"
FT                   /protein_id="CAA16637.1"
FT                   /translation="MSVALLREMFDRMVVAKNAELIEHYYDPDFLMYSDGLSQSFAKFR
FT                   DSHRKLYATAISYAVEYDEHAWVEAQTRLPGGCGSPRRDLARSRPASRWYSLPPTATAE
FT                   FTGSGRRRGRVGATWPPSTITETTTDRLAMRNQLRAGAATLLFCDPMLQRFPATRK"
FT   CDS             complement(73780..74382)
FT                   /transl_table=11
FT                   /locus_tag="Rv3173c"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   (PROBABLY TETR/ACRR-FAMILY)"
FT                   /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM
FT                   (PROBABLY REPRESSION)."
FT                   /note="Rv3173c, (MTV014.17c), len: 200 aa. Probable
FT                   transcriptional regulatory protein tetR family, similar to
FT                   several bacterial putative regulatory proteins e.g.
FT                   Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195 aa),
FT                   FASTA scores: opt: 319, E(): 1.7e-13, (34.55% identity in
FT                   195 aa overlap); O85695|3SCF60.04 from Streptomyces
FT                   lividans and Streptomyces coelicolor (192 aa), FASTA
FT                   scores: opt: 297, E(): 4.3e-12, (37.45% identity in 187 aa
FT                   overlap); BAB50853|MLR4117 from Rhizobium loti
FT                   (Mesorhizobium loti) (205 aa), FASTA scores: opt: 280, E():
FT                   5.5e-11, (31.45% identity in 194 aa overlap);
FT                   BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti)
FT                   (194 aa), FASTA scores: opt: 270, E(): 2.3e-10, (34.05%
FT                   identity in 185 aa overlap); etc. Also similar to other
FT                   regulators from Mycobacterium tuberculosis e.g.
FT                   P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt:
FT                   154, E(): 0.0013, (38.8% identity in 80 aa overlap).
FT                   Contains probable helix-turn-helix motif from aa 39 to 60
FT                   (Score 1251, +3.45 SD). SIMILAR TO THE TETR/ACRR FAMILY OF
FT                   TRANSCRIPTIONAL REGULATORS. TBparse score is 0.925."
FT                   /db_xref="GOA:O53323"
FT                   /db_xref="InterPro:IPR012287"
FT                   /db_xref="UniProtKB/TrEMBL:O53323"
FT                   /protein_id="CAA16638.1"
FT                   /translation="MPPVTRTTEPPRRGGRGARQRILKAAAELFYCEGINATGVELIAN
FT                   KASVSKRTLYQHFPSKSALVEEYLRGLRQAAGEADKMPKASNATPRERLLALFDRPNRG
FT                   DGRMRGCPFHNAAVEAAGEMPGVERIVHSHKRDYIKGLARLAREAGAAHPRSLGNQLAV
FT                   LFEGAAALSTSLDDAGPWAHARAAAEVLIDQATARPV"
FT   CDS             74475..75182
FT                   /transl_table=11
FT                   /locus_tag="Rv3174"
FT                   /product="PROBABLE SHORT-CHAIN DEHYDROGENASE/REDUCTASE"
FT                   /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv3174, (MTV014.18), len: 235 aa. Probable
FT                   oxidoreductase short-chain dehyrogenase/reductase (EC
FT                   1.-.-.-), similar to others e.g. Q9RPT7|SITS from
FT                   Streptomyces albus (223 aa), FASTA scores: opt: 654, E():
FT                   6.1e-32, (49.3% identity in 215 aa overlap);
FT                   Q9RI61|SCJ11.46 from Streptomyces coelicolor (230 aa),
FT                   FASTA scores: opt: 626, E(): 2.9e-30, (50.9% identity in
FT                   224 aa overlap); Q9A5Z1|CC2306 from Caulobacter crescentus
FT                   (252 aa), FASTA scores: opt: 430, E(): 1.3e-18, (39.45%
FT                   identity in 228 aa overlap); Q51641 INSECT-TYPE
FT                   DEHYDROGENASE (249 aa), FASTA scores: opt: 301, E():
FT                   5.7e-11, (38.3% identity in 188 aa overlap); Q9HXC9|PA3883
FT                   from Pseudomonas aeruginosa (276 aa), FASTA scores: opt:
FT                   296, E(): 1.2e-10, (29.55% identity in 247 aa overlap);
FT                   etc. MAY BE BELONG TO THE SHORT-CHAIN
FT                   DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is
FT                   0.900."
FT                   /db_xref="GOA:O53324"
FT                   /db_xref="HSSP:1FDS"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O53324"
FT                   /protein_id="CAA16639.1"
FT                   /translation="MTSLAERTVLVTGANRGMGREYVAQLLGRKVAKVYAATRNPLAID
FT                   VSDPRVIPLQLDVTDAVSVAEAADLATDVGILINNAGISRASSVLDKDTSALRGELETN
FT                   LFGPLALASAFADRIAERSGAIVNVSSVLAWLPLGMSYGVSKAAMWSATESMRIELAPR
FT                   GVQVVGVYVGLVDTDMGRFADAPKSDPADVVRQVLDGIEAGKEDVLADEMSRQVRASLN
FT                   VPARERIARLMGN"
FT   CDS             75197..76684
FT                   /transl_table=11
FT                   /locus_tag="Rv3175"
FT                   /product="POSSIBLE AMIDASE (AMINOHYDROLASE)"
FT                   /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM."
FT                   /EC_number="3.5.1.-"
FT                   /note="Rv3175, (MTV014.19), len: 495 aa. Possible amidase
FT                   (EC 3.5.1.-), similar to others e.g. Q9F6D0|ZHUL ENANTIOMER
FT                   SELECTIVE AMIDASE from Streptomyces sp. R1128 (507 aa),
FT                   FASTA scores: opt: 1328 ,E(): 7.5e-69, (44.5% identity in
FT                   492 aa overlap); BAB51815|MLR5350 PROBABLE AMIDASE from
FT                   Rhizobium loti (Mesorhizobium loti) (457 aa), FASTA scores:
FT                   opt: 7487, E(): 1.3e-35, (35.9% identity in 482 aa
FT                   overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE (EC
FT                   3.5.1.4) from Archaeoglobus fulgidus (453 aa), FASTA
FT                   scores: opt: 532, E(): 3.2e-23, (32.05% identity in 471 aa
FT                   overlap); etc. But also similar to glutamyl-tRNA
FT                   amidotransferases who belong to amidase family e.g.
FT                   Q9RTA9|DR1856 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE, SUBUNIT
FT                   A from Deinococcus radiodurans (482 aa), FASTA scores: opt:
FT                   560, E(): 8.2e-25, (30.6% identity in 513 aa overlap);
FT                   Q9LCX3|GATA GLU/ASP-TRNA AMIDOTRANSFERASE SUBUNIT A from
FT                   Thermus aquaticus (subsp. thermophilus) (471 aa), FASTA
FT                   scores: opt: 558, E(): 1.1e-24, (30.85% identity in 486 aa
FT                   overlap); Q49091|GATA_MORCA GLUTAMYL-TRNA(GLN)
FT                   AMIDOTRANSFERASE SUBUNIT A (EC 6.3.5.-) from Moraxella
FT                   catarrhalis (492 aa), FASTA scores: opt: 526, E(): 7.5e-23,
FT                   (30.45% identity in 473 aa overlap); etc. SEEMS TO BELONG
FT                   TO THE AMIDASE FAMILY. Contains PS00017 ATP/GTP-binding
FT                   site motif A (P-loop). TBparse score is 0.901."
FT                   /db_xref="GOA:O53325"
FT                   /db_xref="HSSP:1M22"
FT                   /db_xref="InterPro:IPR000120"
FT                   /db_xref="UniProtKB/TrEMBL:O53325"
FT                   /protein_id="CAA16640.1"
FT                   /translation="MAMSAKASDDIAWLPATAQLAVLAAKKVSSAELVELYLSRIDTYN
FT                   ASLNAIVTVDPDAARRVAKRSDAARARGDELGPLHGLPITVKDSYETAGMRTTCGRRDL
FT                   ADYVPTQDAEAVARLRRAGAIIMGKTNMPTGNQDVQASNPVFGRTNNPWDAARTSGGSA
FT                   GGGAAATAAGLTSFDYGSEIGGSTRIPAHYCGLYGHKSTWRSVPLVGHIPSAPGNPGRW
FT                   GQADMACAGVQVRGARDIIPALEATVGPMRADGGFSYALAPPRAGALKDFRVAVWAEDP
FT                   HCPIDADVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFAVDRSTL
FT                   SPASAAALGLRAVRHPRGEAANALGATLQSHRAWLFADAARHEMRDRWAGFFNEFDVLL
FT                   LPVTPTPAPLHHNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATTMPITTTAT
FT                   GLPIGIQAMGPAGGDRTTVEFAALLTEVLGGFRVPPL"
FT   misc_feature    75563..75586
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(76681..77637)
FT                   /transl_table=11
FT                   /gene="mesT"
FT                   /locus_tag="Rv3176c"
FT                   /standard_name="lipS"
FT                   /product="PROBABLE EPOXIDE HYDROLASE MEST (EPOXIDE
FT                   HYDRATASE) (ARENE-OXIDE HYDRATASE)"
FT                   /function="BIOTRANSFORMATION ENZYME THAT ACTS ON A VARIETY
FT                   OF EPOXIDES AND ARENE OXIDES. CATALYZES THE HYDROLYSIS OF
FT                   ARENE AND EPOXIDES TO LESS REACTIVE AND MORE WATER SOLUBLE
FT                   DIHYDRODIOLS BY THE TRANS ADDITION OF WATER [CATALYTIC
FT                   ACTIVITY: AN EPOXIDE + H(2)O = A GLYCOL]."
FT                   /EC_number="3.3.2.3"
FT                   /note="Rv3176c, (MTV014.20c), len: 318 aa. Probable mesT,
FT                   epoxide hydrolase (EC 3.3.2.3), similar to others e.g.
FT                   O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM
FT                   SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA
FT                   HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA
FT                   scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa
FT                   overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus
FT                   (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14,
FT                   (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE
FT                   HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese
FT                   pufferfish) (Takifugu rubripes) (326 aa), FASTA scores:
FT                   opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa
FT                   overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from
FT                   Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa), FASTA
FT                   scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa
FT                   overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from
FT                   Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258,
FT                   E(): 3e-09, (29.85% identity in 288 aa overlap);
FT                   O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium
FT                   radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05,
FT                   (27.0% identity in 278 aa overlap); etc. Also similar to
FT                   Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA
FT                   PROTEIN from Mycobacterium tuberculosis (288 aa), FASTA
FT                   scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa
FT                   overlap). Equivalent to AAK47604 from Mycobacterium
FT                   tuberculosis strain CDC1551 (339 aa) but shorter 21 aa.
FT                   SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO
FT                   PEPTIDASE FAMILY S33. Note that previously known as lipS.
FT                   TBparse score is 0.911."
FT                   /db_xref="GOA:Q6MX03"
FT                   /db_xref="UniProtKB/TrEMBL:Q6MX03"
FT                   /protein_id="CAE55562.1"
FT                   /translation="MTHRASALISAQEWFSAGERVGYDAERPGINPRSPLRAFIRRAAG
FT                   TGVTRTFLPGWPDGSYGWAKVEAFLSSRFHFPRIYLDYIGHGDSDKPRDYPYSTFERAD
FT                   LVEALWHAEGIAQTVVVAFDYSCIVSLELLARRIDRERAGNDQRTRITACLLANGGIFA
FT                   DGHTHAWYTTPLLTSPLGAAITPIGQRSWRMFAPFLRPVFSRGYPLSAAEMKELHDAIS
FT                   RRDGVRVLPATAGFVDEHREHAARWDLARIISALGDEVAFGVVGSAEDPFEGEQLRLAR
FT                   ERLADSVEITELAGGHLTTAEQPDRLAEVIAALPERS"
FT   CDS             77784..78644
FT                   /transl_table=11
FT                   /locus_tag="Rv3177"
FT                   /product="POSSIBLE PEROXIDASE (NON-HAEM PEROXIDASE)"
FT                   /function="SUPPOSED INVOLVED IN DETOXIFICATION REACTIONS."
FT                   /EC_number="1.11.1.-"
FT                   /note="Rv3177, (MTV014.21), len: 286 aa. Possible
FT                   peroxidase (non-haem peroxidase) (EC 1.11.1.-), highly
FT                   similar to Q9KJF9|W78 CULTIVAR SPECIFICITY PROTEIN (SIMILAR
FT                   TO ALPHA/BETA HYDROLASE FOLD) W78 from Rhizobium
FT                   leguminosarum (287 aa), FASTA scores: opt: 1059, E():
FT                   2.3e-59, (61.4% identity in 272 aa overlap);
FT                   BAB48728|MLL1328 HYPOTHETICAL PROTEIN from Rhizobium loti
FT                   (Mesorhizobium loti) (286 aa), FASTA scores: opt: 746, E():
FT                   1.1e-39, (43.25% identity in 282 aa overlap). Similar to
FT                   nonheme chloroperoxidases and related esterases e.g.
FT                   O73957|SAL LIPOLYTIC ENZYME from Sulfolobus acidocaldarius
FT                   (314 aa), FASTA scores: opt: 408, E(): 1.9e-18, (32.4%
FT                   identity in 287 aa overlap); Q9AJM9|BIOH PROTEIN INVOLVED
FT                   IN BIOTIN SYNTHESIS from Kurthia sp. 538-KA26 (267 aa),
FT                   FASTA scores: opt: 324 ,E(): 3.2e-13, (30.0% identity in
FT                   250 aa overlap); Q9CBB1|ML2269 PUTATIVE HYDROLASE (SIMILAR
FT                   TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae
FT                   (265 aa); O05691|THCF_RHOER NON-HEME HALOPEROXIDASE (EC
FT                   1.11.1.-) from Rhodococcus erythropolis (SIMILAR TO OTHER
FT                   BACTERIAL NON-HEME BROMO- AND CHLORO-PEROXIDASES) (274 aa),
FT                   FASTA scores: opt: 279, E(): 2.2e-10, (29.0% identity in
FT                   276 aa overlap); Q53540|EST ESTERASE (SIMILAR TO ALPHA/BETA
FT                   HYDROLASE FOLD) from Pseudomonas putida (276 aa), FASTA
FT                   scores: opt: 271, E(): 7.1e-10, (29.65% identity in 280 aa
FT                   overlap); etc. Also similar to
FT                   O06420|BPOC|Rv0554|MTCY25D10.33 HYPOTHETICAL 28.3 KDA
FT                   PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from M.
FT                   tuberculosis (262 aa), FASTA scores: opt: 280 ,E():
FT                   1.8e-10, (28.0% identity in 257 aa overlap). Equivalent to
FT                   AAK47605 from Mycobacterium tuberculosis strain CDC1551
FT                   (300 aa) but shorter 14 aa. SIMILAR TO ALPHA/BETA HYDROLASE
FT                   FOLD. TBparse score is 0.913."
FT                   /db_xref="GOA:O53327"
FT                   /db_xref="InterPro:IPR000073"
FT                   /db_xref="UniProtKB/TrEMBL:O53327"
FT                   /protein_id="CAA16642.1"
FT                   /translation="MPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLGADAGVPVIFLH
FT                   HLGAVLDNWDPRVVDGIAAKHPVVTFDNRGVGASEGQTPDTVTTMADDAIAFVRALGFD
FT                   QVDLLGFSLGGFVAQVIAQQEPQLVRKIILAGTGPAGGVGIGKVTFGTIRESIKATLTF
FT                   RDPKELRFFTRTDSGKSAARQFVKRLKERKDNRDKSITVRAFRSQLKAIHAWGTQKPSD
FT                   LTSIGHPVLIANGDDDTMVPTSNSLDLADRLPDATLRIYPDAGHGGIFQHHAQFVDDAL
FT                   QFLES"
FT   CDS             78775..79134
FT                   /transl_table=11
FT                   /locus_tag="Rv3178"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3178, (MTV014.22), len: 119 aa. Hypothetical
FT                   protein, with some similarity to other hypothetical
FT                   bacterial proteins (principaly mycobacterium and
FT                   streptomyces proteins) e.g. P71854|Rv3547|MTCY03C7.09c from
FT                   Mycobacterium tuberculosis strain H37Rv (151 aa), FASTA
FT                   scores: opt: 310, E(): 2e-14, (40.5% identity in 116 aa
FT                   overlap); Q9ZH81 from M. paratuberculosis (144 aa), FASTA
FT                   scores: opt: 274, E(): 5.6e-12, (38.9% identity in 108 aa
FT                   overlap); O85698|3SCF60.07 from Streptomyces lividans and
FT                   Streptomyces coelicolor (149 aa), FASTA scores: opt: 235,
FT                   E(): 2.7e-09, (35.2% identity in 108 aa overlap);
FT                   Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c (148 aa);
FT                   Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa); etc.
FT                   Equivalent to AAK47606 from Mycobacterium tuberculosis
FT                   strain CDC1551 (171 aa) but shorter 52 aa."
FT                   /db_xref="InterPro:IPR004378"
FT                   /db_xref="UniProtKB/TrEMBL:O53328"
FT                   /protein_id="CAA16643.1"
FT                   /translation="MRLGAGFRKPVPTLLLEHRSRKSGKNFVAPLLYITDRNNVIVVAS
FT                   ALGQAENPQWYRNLPPNPDTHIQIGSDRRPVRAVVASSDERARLWPRPVDAYADFDSCQ
FT                   SWTERGIPVIILRPR"
FT   CDS             79955..81244
FT                   /transl_table=11
FT                   /locus_tag="Rv3179"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3179, (MTV014.23), len: 429 aa. Conserved
FT                   hypothetical protein, highly similar to Q9KH61 PUTATIVE
FT                   ATP/GTP BINDING PROTEIN from Mycobacterium smegmatis (428
FT                   aa), FASTA scores: opt: 2466, E(): 1.5e-148, (89.7%
FT                   identity in 428 aa overlap) (no article found on the NCBI
FT                   web site (July 2001)); and to other hypothetical bacterial
FT                   proteins e.g. O07781|Rv0597c|MTCY19H5.25 from M.
FT                   tuberculosis (411 aa), FASTA scores: opt: 1031, E(): 8e-58,
FT                   (41.5% identity in 417 aa overlap); BAB54715|MLR9349 from
FT                   Rhizobium loti (Mesorhizobium loti) (435 aa), FASTA scores:
FT                   opt: 365, E(): 1.1e-15, (31.75% identity in 416 aa
FT                   overlap); etc. Equivalent to AAK47609 from Mycobacterium
FT                   tuberculosis strain CDC1551 (454 aa) but shorter 25 aa.
FT                   Contains PS00017 ATP/GTP-binding site motif A (P-loop).
FT                   TBparse score is 0.923."
FT                   /db_xref="UniProtKB/TrEMBL:O53329"
FT                   /protein_id="CAA16644.1"
FT                   /translation="MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQQ
FT                   LHAELGGWLRSLDVDVERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATDRD
FT                   RRPRQFFLSGSTRFLTVPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEPQVV
FT                   LGTEPAPVTRHEYLQLACAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKRIEQT
FT                   DRLPRFMRYLAAITAQELNVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWSRNLTA
FT                   KIKKRSKIHVVDSGFAAWLRGQSADSLARPTAEGAGPIMETFVINELMKLRAATELEVD
FT                   LYHFRDRDGREIDCILQTPDSRVVGVEVKASATVNVHDFRHLSFARDRLGDEFITGVLF
FT                   YTGARALPFGDRLMALPINLLWNGQSVSSL"
FT   misc_feature    80051..80074
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(81591..82025)
FT                   /transl_table=11
FT                   /locus_tag="Rv3180c"
FT                   /product="HYPOTHETICAL ALANINE RICH PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3180c, (MTV014.24c), len: 144 aa. Hypothetical
FT                   unknown ala-rich protein. Contains probable coiled-coil
FT                   domain from aa 40 to 70."
FT                   /db_xref="UniProtKB/TrEMBL:O53330"
FT                   /protein_id="CAA16645.1"
FT                   /translation="MPLVYFDASAFVKLLTTETGSSLASALWDGCDAALSSRLAYPEVR
FT                   AALAAAARNHDLTESELADAERDWEDFWAATRPVELTATVEQHAGHLARAHALRGADAV
FT                   HLASALAVGDPGLVVAVWDRRLHTGAHAAGCRVAPAQLDP"
FT   CDS             complement(82028..82480)
FT                   /transl_table=11
FT                   /locus_tag="Rv3181c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3181c, (MTV014.25c), len: 150 aa. Hypothetical
FT                   protein, with some similarity to other mycobacterium
FT                   proteins e.g. Q50718|YY07_MYCTU|Rv3407|MT3515|MTCY78.21c
FT                   (99 aa), FASTA scores: opt: 123, E(): 0.25, (33.7% identity
FT                   in 89 aa overlap); and O50412|Rv3385c|MTV004.43c (102 aa),
FT                   FASTA scores: opt: 123, E(): 0.26, (39.7% identity in 68 aa
FT                   overlap). TBparse score is 0.910."
FT                   /db_xref="InterPro:IPR006442"
FT                   /db_xref="UniProtKB/TrEMBL:O53331"
FT                   /protein_id="CAA16646.1"
FT                   /translation="MQLGRKVTSHHDIDRFGVASTADESVYRPLPPRLRLAQVNLSRRR
FT                   CRTQSDMYKSRFSECTVQSVDVSVTELRAHLSDWLDRARAGGEVVITERGIPIARLAAL
FT                   DSTDTLERLTAEGVIGKATAQRPVAAGRPRPRPQRPVSDRVSDQRR"
FT   CDS             82711..83055
FT                   /transl_table=11
FT                   /locus_tag="Rv3182"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3182, (MTV014.26), len: 114 aa. Hypothetical
FT                   protein, with some similarity to other hypothetical
FT                   bacterial proteins e.g. O53468|Rv2022c|MTV018.09c from M.
FT                   tuberculosis (201 aa), FASTA scores: opt: 335, E():
FT                   3.6e-16, (51.9% identity in 104 aa overlap); and
FT                   Q9L3R6|ORF119 from Anabaena sp. strain PCC 7120 (119 aa),
FT                   FASTA scores: opt: 250, E(): 1.6e-10, (42.1% identity in 95
FT                   aa overlap). Equivalent to AAK47614 from Mycobacterium
FT                   tuberculosis strain CDC1551 (94 aa) but longer 20 aa."
FT                   /db_xref="InterPro:IPR018670"
FT                   /db_xref="UniProtKB/TrEMBL:O53332"
FT                   /protein_id="CAA16647.1"
FT                   /translation="MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDK
FT                   VNDSTFHNMKELRPAGTSIRILFAFDPARQAILLLGGDKAGNWKRWYDNNIPIADQRSE
FT                   NWLASEHGGG"
FT   CDS             83052..83381
FT                   /transl_table=11
FT                   /locus_tag="Rv3183"
FT                   /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv3183, (MTV014.27), len: 109 aa. Possible
FT                   transcriptional regulator, similar to others e.g.
FT                   Q9S1D9|YPPCP1.08c from Yersinia pestis (99 aa), FASTA
FT                   scores: opt: 119, E(): 0.47, (40.55% identity in 74 aa
FT                   overlap); Q9X153|TM1330 from Thermotoga maritima (111 aa),
FT                   FASTA scores: opt: 115, E(): 0.91, (40.35% identity in 57
FT                   aa overlap); P95258|Rv1956|MTCY09F9.08c (alias AAK46277
FT                   putative DNA-binding protein from strain CDC1551) (149 aa),
FT                   FASTA scores: opt: 116, E(): 1, (42.25% identity in 71 aa
FT                   overlap). Also similar to O53467|Rv2021c|MTV018.08c from
FT                   Mycobacterium tuberculosis (101 aa), FASTA scores: opt:
FT                   214, E(): 5.8e-07, (43.0% identity in 107 aa overlap).
FT                   Contains probable helix-turn-helix motif from aa 51 to 72
FT                   (Score 1803, +5.33 SD). TBparse score is 0.852."
FT                   /db_xref="GOA:O53333"
FT                   /db_xref="InterPro:IPR001387"
FT                   /db_xref="UniProtKB/TrEMBL:O53333"
FT                   /protein_id="CAA16648.1"
FT                   /translation="MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIR
FT                   KALGHARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIVAEFGENT
FT                   VELTA"
FT   repeat_region   83564..83566
FT                   /note="3 bp direct repeat, cga, at 5'-end of IS6110"
FT   repeat_region   83567..83594
FT                   /note="28 bp inverted repeat at left end of IS6110,
FT                   TGAACCGCCCCGGCATGTCCGGAGACTC"
FT   repeat_region   83567..84921
FT                   /mobile_element="insertion sequence:IS6110-12"
FT                   /note="IS6110-12, len: 1355 bp. Insertion sequence IS6110."
FT   CDS             83618..83944
FT                   /transl_table=11
FT                   /locus_tag="Rv3184"
FT                   /product="PROBABLE TRANSPOSASE"
FT                   /function="INVOLVED IN THE TRANSPOSITION IN THE INSERTION
FT                   SEQUENCE IS6110."
FT                   /note="Rv3184, (MTV014.28), len: 108 aa. Probable IS6110
FT                   transposase. TBparse score is 0.928."
FT                   /db_xref="GOA:P0C5G9"
FT                   /db_xref="InterPro:IPR002514"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0C5G9"
FT                   /protein_id="CAA16649.1"
FT                   /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG
FT                   CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD
FT                   RPAR"
FT   CDS             <83941..84879
FT                   /transl_table=11
FT                   /locus_tag="Rv3185"
FT                   /product="PROBABLE TRANSPOSASE"
FT                   /function="INVOLVED IN THE TRANSPOSITION IN THE INSERTION
FT                   SEQUENCE IS6110."
FT                   /note="Rv3185, (MTV014.29), len: 312 aa. Probable IS6110
FT                   transposase. TBparse score is 0.926."
FT                   /db_xref="GOA:P0C5G8"
FT                   /db_xref="InterPro:IPR001584"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0C5G8"
FT                   /protein_id="CAA16650.1"
FT                   /translation="LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYDH
FT                   INREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLG
FT                   LSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVT
FT                   DAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFS
FT                   ERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWF
FT                   NHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
FT   repeat_region   complement(84894..84921)
FT                   /note="28 bp inverted repeat at right end of IS6110,
FT                   TGAACCGCCCCGGTGAGTCCGGAGACTC"
FT   repeat_region   84922..84924
FT                   /note="3 bp direct repeat, cga, at 3'-end of IS6110"
FT   repeat_region   85047..85049
FT                   /note="3 bp direct repeat, att, at 5'-end of IS6110"
FT   repeat_region   85050..85077
FT                   /note="28 bp inverted repeat at left end of IS6110,
FT                   TGAACCGCCCCGGCATGTCCGGAGACTC"
FT   repeat_region   85050..86404
FT                   /mobile_element="insertion sequence:IS6110-13"
FT                   /note="IS6110-13, len: 1355 bp. Insertion sequence IS6110."
FT   CDS             85101..85427
FT                   /transl_table=11
FT                   /locus_tag="Rv3186"
FT                   /product="PROBABLE TRANSPOSASE"
FT                   /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION
FT                   SEQUENCE IS6110."
FT                   /note="Rv3186, (MTV014.30), len: 108 aa. Probable IS6110
FT                   transposase. TBparse score is 0.928."
FT                   /db_xref="GOA:P0C5G9"
FT                   /db_xref="InterPro:IPR002514"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0C5G9"
FT                   /protein_id="CAA16651.1"
FT                   /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG
FT                   CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD
FT                   RPAR"
FT   CDS             <85424..86362
FT                   /transl_table=11
FT                   /locus_tag="Rv3187"
FT                   /product="PROBABLE TRANSPOSASE"
FT                   /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION
FT                   SEQUENCE IS6110."
FT                   /note="Rv3187, (MTV014.31), len: 312 aa. Probable IS6110
FT                   transposase."
FT                   /db_xref="GOA:P0C5G8"
FT                   /db_xref="InterPro:IPR001584"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0C5G8"
FT                   /protein_id="CAA16652.1"
FT                   /translation="LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYDH
FT                   INREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLG
FT                   LSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVT
FT                   DAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFS
FT                   ERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWF
FT                   NHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
FT   repeat_region   complement(86377..86404)
FT                   /note="28 bp inverted repeat at right end of IS6110,
FT                   TGAACCGCCCCGGTGAGTCCGGAGACTC"
FT   repeat_region   86405..86407
FT                   /note="3 bp direct repeat, att, at 5'-end of IS6110"
FT   CDS             86635..86982
FT                   /transl_table=11
FT                   /locus_tag="Rv3188"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3188, (MTV014.32), len: 115 aa. Conserved
FT                   hypothetical protein, with similarity to other proteins
FT                   from Mycobacterium tuberculosis:
FT                   Q10868|YJ90_MYCTU|Rv1990c|MT2044|MTCY39.29 HYPOTHETICAL
FT                   PROTEIN (113 aa), FASTA scores: opt: 184, E(): 8.1e-06,
FT                   (28.45% identity in 109 aa overlap); and
FT                   O06299|Rv0348|MTCY13E10.08 HYPOTHETICAL PROTEIN (217 aa),
FT                   FASTA scores: opt: 129, E(): 0.074, (30.0% identity in 100
FT                   aa overlap). Also some similarity with C-terminus of
FT                   Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE
FT                   TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218
FT                   aa), FASTA scores: opt: 114, E(): 0.76, (30.0% identity in
FT                   110 aa overlap) (for this one, no similarity exists in the
FT                   N-terminal region with the N-terminus of other regulatory
FT                   components of sensory transduction systems). TBparse score
FT                   is 0.881."
FT                   /db_xref="UniProtKB/TrEMBL:O53334"
FT                   /protein_id="CAA16653.1"
FT                   /translation="MAVTLDRAVEASEIVDALKPFGVTQVDVAAVIQVSDRAVRGWRTG
FT                   DIRPERYDRLAQLRDLVLLLSDSLTPRGVGQWLHAKNRLLDGQRPVDLLAKDRYEDVRS
FT                   AAESFIDGAYV"
FT   CDS             86979..87599
FT                   /transl_table=11
FT                   /locus_tag="Rv3189"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3189, (MTV014.33), len: 206 aa. Conserved
FT                   hypothetical protein, weakly similar to other proteins from
FT                   Mycobacterium tuberculosis e.g.
FT                   O86329|MBTE|Rv2380c|MTCY22H8.05 (1682 aa), FASTA scores:
FT                   opt: 135, E(): 0.79, (27.8% identity in 187 aa overlap);
FT                   and Q10869|YJ89_MYCTU|Rv1989c|MT2043MTCY39.30 (186 aa),
FT                   FASTA scores: opt: 122, E(): 0.85, (32.25% identity in 93
FT                   aa overlap). TBparse score is 0.881."
FT                   /db_xref="InterPro:IPR014914"
FT                   /db_xref="UniProtKB/TrEMBL:O53335"
FT                   /protein_id="CAA16654.1"
FT                   /translation="MKLADAIATAPRRTLKGTYWHQGPTRHPVTSCADPARGPGRYHRT
FT                   GEPGVWYASNKEQGAWAELFRHFVDDGVDPFEVRRRVGRVAVTLQVLDLTDERTRSHLG
FT                   VDETDLLSDDYTTTQAIAAARDANFDAVLAPAAALPGCQTLAVFVHALPNIEPERSEVR
FT                   QPPPRLANLLPLIRPHEHMPDSVRRLLATLTRAGAEAIRRRRR"
FT   CDS             complement(87759..89024)
FT                   /transl_table=11
FT                   /locus_tag="Rv3190c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3190c, (MTV014.34c), len: 421 aa. Hypothetical
FT                   unknown protein. TBparse score is 0.937."
FT                   /db_xref="UniProtKB/TrEMBL:O53336"
FT                   /protein_id="CAA16655.1"
FT                   /translation="MEYVQLFSKGRLNDLAGSLAGFLGKASQATAQRLQSWDADDLLNT
FT                   PVDDVVEQLVELGSVECPDLRVDDAFMLPATEVDQQYRDWGEQRTRRVTRLVLVVPFEG
FT                   HKDIFNLRPDQFTTMPPQVLRLQGHEIHLAIDNLSNDAAAINAAFHKQIANIEKYLGWS
FT                   RRQIDLHNQGLRNELPGMVARRREQLLATRNLQAEIGFPVRRRKDADTYAAPISRKSVR
FT                   PRPHRPAGARAAFKPEPAMQDEDYQSALRVLRNQRNALERTPSVAAKLDGEEIRDMLLV
FT                   GLNAQFEGDAGGELFNGAGKTDILIRVDDRNIFIGECKVWSGPRTMDDVLKQLFGYLVW
FT                   RDTKAAILLFIRNKDVTAVIDNAIAKIKEHPNHKRCPAHRAGADQYEFTMHADGDPERE
FT                   IHLTLIPFALRPTAEVPTTTIP"
FT   CDS             complement(89648..90682)
FT                   /transl_table=11
FT                   /locus_tag="Rv3191c"
FT                   /product="PROBABLE TRANSPOSASE"
FT                   /function="INVOLVED IN THE TRANSPOSITION OF AN INSERTION
FT                   SEQUENCE."
FT                   /note="Rv3191c, (MTV014.35c), len: 344 aa. Probable
FT                   transposase, similar to many especially Q9K2N8 PUTATIVE
FT                   TRANSPOSASE from Pseudomonas aeruginosa (338 aa), FASTA
FT                   scores: opt: 837, E(): 1.3e-43, (42.55% identity in 336 aa
FT                   overlap); Q9RBF4 INSERTION SEQUENCE IS1088 from Alcaligenes
FT                   eutrophus (Ralstonia eutropha) (342 aa), FASTA scores: opt:
FT                   823, E(): 9.2e-43, (43.05% identity in 337 aa overlap); and
FT                   Q51379 PUTATIVE TRANSPOSASE from Pseudomonas alcaligenes
FT                   (338 aa), FASTA scores: opt: 818, E(): 1.8e-42, (42.35%
FT                   identity in 333 aa overlap). Contains probable
FT                   helix-turn-helix motif from aa 25 to 46 (Score 1968, +5.89
FT                   SD)."
FT                   /db_xref="GOA:O53337"
FT                   /db_xref="InterPro:IPR001584"
FT                   /db_xref="UniProtKB/TrEMBL:O53337"
FT                   /protein_id="CAA16656.1"
FT                   /translation="MRQISSRYLSEEERINIADLRRSGLSIRKIADQLGRAPSTVSREL
FT                   RRNSRRDGQYRPFEAHRWAVQRRVRRHRRRIDKNPDLCELIAELLAQRWSPQQIARHLR
FT                   RKYPDDRSMWLCHESIYQAVYQPQSRLIRPPQVKSPHRGPLRTGRTHRRAHLRPGRRRP
FT                   RFAQPMLSIHQRPFDPADRSEPGHWEGDLIVGKNQGSAIGTLVERQTRLIRLLHLPTHD
FT                   AYCLRIAITETMSDLPVTLVRSITWDQGIEMARHIDITADLGAPVYFCDSRSPWQRASN
FT                   ENSNGLLRQYFPKGTSLSTYTPDHLRAVEYEINNRPRQVLGHRSPAELFTALLTSPDHQ
FT                   LLRR"
FT   repeat_region   complement(89651..90682)
FT                   /mobile_element="insertion sequence:IS1603"
FT                   /note="IS1603, len: 1032 bp. Insertion sequence IS1603."
FT   tRNA            complement(91707..91780)
FT                   /gene="tRNA-Met(CAT)"
FT                   /product="transfer RNA-Met(CAT)"
FT                   /anticodon=(pos:91744..91746,aa:Met)
FT   CDS             91900..92361
FT                   /transl_table=11
FT                   /locus_tag="Rv3192"
FT                   /product="CONSERVED HYPOTHETICAL ALANINE AND PROLINE-RICH
FT                   PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3192, (MTV014.36), len: 153 aa. Conserved
FT                   hypothetical ala- and pro-rich protein, with weak
FT                   similarity to N-terminal half of several proteins e.g.
FT                   Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL
FT                   37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa),
FT                   FASTA scores: opt: 245, E(): 3.7e-08, (33.1% identity in
FT                   157 aa overlap); O30260|AF2411 CONSERVED HYPOTHETICAL
FT                   PROTEIN from Archaeoglobus fulgidus (363 aa), FASTA scores:
FT                   opt: 144, E(): 0.072, (32.6% identity in 92 aa overlap);
FT                   Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from
FT                   Streptomyces violaceoruber (343 aa), FASTA scores: opt:
FT                   133, E(): 0.33, (25.15% identity in 159 aa overlap).
FT                   TBparse score is 0.920."
FT                   /db_xref="UniProtKB/TrEMBL:O53338"
FT                   /protein_id="CAA16657.1"
FT                   /translation="MIPQPLSQLGDLARRPGRRVLCSPKTAAPSISNATVASPAAPGLE
FT                   LSTGIALAFPRGPFVPAAAAWELQEATSGKFQLGLGTQVRKNVVHRYGMAFHRPGPRLR
FT                   YLLAVKACFAVFQTGTPDHHGEFDNPDFITAQWSPARIDPPGPSPAGPR"
FT   CDS             complement(92531..95509)
FT                   /transl_table=11
FT                   /locus_tag="Rv3193c"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3193c, (MTV014.37c), len: 992 aa. Probable
FT                   conserved transmembrane protein, with hydrophobic
FT                   N-terminal domain (~1-340 aa), highly similar to
FT                   Q9CCM6|ML0644 PUTATIVE INTEGRAL MEMBRANE PROTEIN from
FT                   Mycobacterium leprae (983 aa), FASTA scores: opt: 5421,
FT                   E(): 0, (86.15% identity in 989 aa overlap); and
FT                   O53609|Rv0064|MTV030.07 PUTATIVE MEMBRANE PROTEIN from
FT                   Mycobacterium tuberculosis strain H37Rv (979 aa), FASTA
FT                   scores: opt: 3204, E(): 2.1e-142, (50.25% identity in 985
FT                   aa overlap). C-terminal part (709-990 aa) highly similar to
FT                   O32904|MLCB1779.46 HYPOTHETICAL 29.1 KDA PROTEIN from
FT                   Mycobacterium leprae (277 aa), FASTA scores: opt: 1521,
FT                   E(): 3.4e-64, (82.6% identity in 282 aa overlap). Also some
FT                   similarity to hypothetical proteins generally transmembrane
FT                   e.g. Q9FCI4|2SC3B6.28 from Streptomyces coelicolor (815
FT                   aa), FASTA scores: opt: 951, E(): 3.4e-37, (39.2% identity
FT                   in 826 aa overlap); P72637|SLL1060 from Synechocystis sp.
FT                   strain PCC 6803 (1032 aa), FASTA scores: opt: 938, E():
FT                   1.6e-36, (29.95% identity in 855 aa overlap); O28851|AF1421
FT                   from Archaeoglobus fulgidus (880 aa), FASTA scores: opt:
FT                   526, E(): 2.6e-17, (28.05% identity in 970 aa overlap);
FT                   etc."
FT                   /db_xref="GOA:O53339"
FT                   /db_xref="InterPro:IPR005372"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53339"
FT                   /protein_id="CAA16658.1"
FT                   /translation="MGMRSAARMPKLTRRSRILIMIALGVIVLLLAGPRLIDAYVDWLW
FT                   FGELGYRSVFTTMLATRIVVCLVAGVVVGGIVFGGLALAYRTRPVFVPDADNDPVARYR
FT                   AVVLARLRLVGIGIPAAIGLLAGIVAQSYWARIQLFLHGGDFGVRDPQFGRDLGFYAFE
FT                   LPFYRLMLSYMLVSVFLAFVANLVAHYIFGGIRLSGRTGALSRSARVQLVSLVGVLVLL
FT                   KAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAAAVFSAIALRD
FT                   LRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSITATRQAYGLTSD
FT                   VVTYRNYSGDSPATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFPDQLSID
FT                   RYLDRNGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGFIASPANTVRGIANDP
FT                   NQNGGYPEFLVNVVGANGTVVSDGPAPLDQPRIYFGPVISNTSADYAIVGRNGDDREYD
FT                   YETNIDTKRYTYTGSGGVPLGGWLARSVFAAKFAERNFLFSNVIGSNSKILFNRDPAQR
FT                   VEAVAPWLTTDSAVYPAIVNKRLVWIVDGYTTLDNYPYSELTSLSSATADSNEVAFNRL
FT                   VPDKKVSYIRNSVKATVDAYDGTVTLYQQDEKDPVLKAWMQVFPGTVKPKSDIAPELAE
FT                   HLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASSYQPPYYIVAKNIA
FT                   KDDNSASYQLISAMNRFKRDYLAAYISASSDPATYGNLTVLTIPGQVNGPKLANNAITT
FT                   DPAVSQDLGVIGRDNQNRIRWGNLLTLPVARGGLLYVEPVYASPGASDAASSYPRLIRV
FT                   AMMYNDKVGYGPTVRDALTGLFGPGAGATATGIAPTEAAVPPSPAANPPPPASGPQPPP
FT                   VTAAPPVPVGAVTLSPAKVAALQEIQAAIGAARDAQKKGDFAAYGSALQRLDEAITKFN
FT                   DAG"
FT   CDS             complement(95601..96623)
FT                   /transl_table=11
FT                   /locus_tag="Rv3194c"
FT                   /product="POSSIBLE CONSERVED SECRETED PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3194c, (MTV014.38c), len: 340 aa. Possible
FT                   conserved secreted protein (N-terminal stretch
FT                   hydrophobic), equivalent to Q9CCM7|ML0643 PUTATIVE SECRETED
FT                   PROTEIN from Mycobacterium leprae (340 aa), FASTA scores:
FT                   opt: 1822, E(): 1.6e-102, (80.3% identity in 340 aa
FT                   overlap). Also similar to other proteins e.g.
FT                   Q9FCI6|2SC3B6.26 PUTATIVE SECRETED PROTEIN from
FT                   Streptomyces coelicolor (364 aa), FASTA scores: opt: 430,
FT                   E(): 1.1e-18, (40.95% identity in 359 aa overlap);
FT                   Q9S3Y5|SDRC SDRC PROTEIN from Streptomyces coelicolor (241
FT                   aa), FASTA scores: opt: 396, E(): 8.9e-17, (35.2% identity
FT                   in 318 aa overlap) (similarity in part for this one);
FT                   O34470|YLBL YLBL PROTEIN from Bacillus subtilis (350 aa),
FT                   FASTA scores: opt: 385, E(): 5.6e-16, (27.7% identity in
FT                   350 aa overlap); etc. TBparse score is 0.890."
FT                   /db_xref="GOA:O53340"
FT                   /db_xref="InterPro:IPR001478"
FT                   /db_xref="UniProtKB/TrEMBL:O53340"
FT                   /protein_id="CAA16659.1"
FT                   /translation="MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEID
FT                   GKQVVQIVGTQTYPTSGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGKSR
FT                   EEIENDNAADFKRSEAAAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGT
FT                   PVGNLDQFTALLKNTKPGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPW
FT                   APFAVDFHLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGGIT
FT                   HKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALHAMTSGSPTPSC
FT                   "
FT   CDS             96701..98119
FT                   /transl_table=11
FT                   /locus_tag="Rv3195"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3195, (MTV014.39), len: 472 aa. Hypothetical
FT                   protein, equivalent to Q49746|ML0642|B1937_C3_231
FT                   HYPOTHETICAL 50.3 KDA PROTEIN from Mycobacterium leprae
FT                   (479 aa), FASTA scores: opt: 2503, E(): 1e-138, (79.35%
FT                   identity in 475 aa overlap). Similar in part to
FT                   Q9FCI9|2SC3B6.23c CONSERVED HYPOTHETICAL PROTEIN from
FT                   Streptomyces coelicolor (487 aa), FASTA scores: opt: 1382,
FT                   E(): 2.7e-73, (46.4% identity in 489 aa overlap);
FT                   Q9X8I7|SCE9.14 HYPOTHETICAL 41.2 KDA PROTEIN from
FT                   Streptomyces coelicolor (375 aa), FASTA scores: opt: 319,
FT                   E(): 2.4e-11, (25.6% identity in 383 aa overlap); etc.
FT                   TBparse score is 0.893."
FT                   /db_xref="InterPro:IPR018766"
FT                   /db_xref="UniProtKB/TrEMBL:O53341"
FT                   /protein_id="CAA16660.1"
FT                   /translation="MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPLG
FT                   AFGIGGEFNMADLGQIFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIAPI
FT                   PAATNSAIADAVHLADTWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMAQQI
FT                   STVWASSLPEEAKSMAGPLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLPLGPK
FT                   GVAAILPGAVESFAAGLEQPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVEAYAMG
FT                   MKIDMTGIEELARDINPTSLADPAAMEQLLSQGVFEPKATPAQTQALERLETLLALIEG
FT                   WVQTVVTAALGERIPGEAALSETLRRRRASGGPAEQTFATLVGLELRPRKLREAGALWE
FT                   RLTRAVGMDARDAVWQHPDLLPATDDLDDPAAFIDRVIGGDTSGIDEAIAELERDQQAR
FT                   GADDSGHDGGPVDN"
FT   CDS             98125..99024
FT                   /transl_table=11
FT                   /locus_tag="Rv3196"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3196, (MTV014.40), len: 299 aa. Hypothetical
FT                   protein, with some similarity to other hypothetical
FT                   proteins e.g. Q9FCJ5|2SC3B6.17c PUTATIVE SECRETED PROTEIN
FT                   from Streptomyces coelicolor (442 aa), FASTA scores: opt:
FT                   233, E(): 3.5e-07, (29.9% identity in 261 aa overlap).
FT                   TBparse score is 0.936."
FT                   /db_xref="UniProtKB/TrEMBL:O53342"
FT                   /protein_id="CAA16661.1"
FT                   /translation="MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRRA
FT                   VLVRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGVAT
FT                   PLANPGNLDSRRRAASIRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVDLVV
FT                   LSDYLVADPHMVRDLHTERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSDRDAA
FT                   WPAIAAQLRDTVGVADRATLLATAALALSQVNRVIAAVRGQEATPEPPSALNTTLEFDL
FT                   NAGSIVARQWTRHPRCFC"
FT   CDS             complement(99033..99233)
FT                   /transl_table=11
FT                   /locus_tag="Rv3196A"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3196A, len: 66 aa. Hypothetical unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:Q8VJ55"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55563.1"
FT                   /translation="MQEGGPQETMSARSTQHDAADALFRAIIETLDKHRNERTLTEDVL
FT                   DTLARAYASISTNVPEQGRLG"
FT   CDS             99361..100704
FT                   /transl_table=11
FT                   /locus_tag="Rv3197"
FT                   /product="PROBABLE CONSERVED ATP-BINDING PROTEIN ABC
FT                   TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT
FT                   ACROSS THE MEMBRANE. RESPONSIBLE FOR ENERGY COUPLING TO THE
FT                   TRANSPORT SYSTEM."
FT                   /note="Rv3197, (MTV014.41), len: 447 aa. Probable conserved
FT                   ATP-binding protein ABC transporter, highly similar to
FT                   Mycobacterium leprae proteins: Q9CCM8|ML0640 HYPOTHETICAL
FT                   PROTEIN (473 aa), FASTA scores: opt: 2512, E(): 2.1e-140,
FT                   (83.0% identity in 447 aa overlap). Interestingly, the
FT                   N-terminal half (1-219 aa) corresponds to
FT                   Q49747|ABC1|B1937_C3_233 ABC1 PROTEIN from Mycobacterium
FT                   leprae (267 aa), FASTA scores: opt: 1276, E(): 6.3e-68,
FT                   (88.6% identity in 219 aa overlap); and the C-terminal half
FT                   (239-447 aa) corresponds to Q49745|B1937_C2_179
FT                   HYPOTHETICAL 23.1 KDA PROTEIN (206 aa), FASTA scores: opt:
FT                   1138, E(): 6.5e-60, (77.05% identity in 209 aa overlap);
FT                   two adjacent orfs from Mycobacterium leprae. Also highly
FT                   similar to other proteins (generally ABC transporters) e.g.
FT                   Q9FCJ6|2SC3B6.16c HYPOTHETICAL 51.3 KDA PROTEIN from
FT                   Streptomyces coelicolor (469 aa), FASTA scores: opt: 1340,
FT                   E(): 1.8e-71, (45.9% identity in 449 aa overlap);
FT                   O65576|ABC1AT ABC1 PROTEIN (alias
FT                   Q9SBB2|T15B16.14|AT4G01660 PUTATIVE ABC TRANSPORTER) from
FT                   Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA
FT                   scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa
FT                   overlap); O27682|MTH1645 ABC TRANSPORTER from
FT                   Methanobacterium thermoautotrophicum (623 aa), FASTA
FT                   scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa
FT                   overlap); etc. Contains PS00017 ATP/GTP-binding site motif
FT                   A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN
FT                   FAMILY (ABC TRANSPORTERS). TBparse score is 0.892."
FT                   /db_xref="GOA:O53343"
FT                   /db_xref="InterPro:IPR004147"
FT                   /db_xref="UniProtKB/TrEMBL:O53343"
FT                   /protein_id="CAA16662.1"
FT                   /translation="MDDGSVSDIKRGRAARNAKLASIPVGFAGRAALGLGKRLTGKSKD
FT                   EVTAELMEKAANQLFTVLGELKGGAMKVGQALSVMEAAIPDEFGEPYREALTKLQKDAP
FT                   PLPASKVHRVLDGQLGTKWRERFSSFNDTPVASASIGQVHKAIWSDGREVAVKIQYPGA
FT                   DEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVERTEMELDYRLEAANQRAFAKAYH
FT                   DHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDAPRRLG
FT                   LMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPGGFPIELGMTIRLAREKNYDLLLPTMEK
FT                   AGLIQRGRQVSVREIDEMLRQYVEPIQVEVFHYTRKWLQKMTVSQIDRSVAQIRTARQM
FT                   DLPAKLAIPMRVIASVGAILCQLDAHVPIKALSEELIPGFAEPDAIVV"
FT   misc_feature    99466..99489
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(100738..101016)
FT                   /transl_table=11
FT                   /gene="whiB7"
FT                   /locus_tag="Rv3197A"
FT                   /standard_name="whmC"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   WHIB-LIKE WHIB7"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv3197A, len: 92 aa. Probable whiB7 (alternate gene
FT                   name: whmC), WhiB-like regulatory protein (see citation
FT                   below), similar to WhiB paralogue of Streptomyces
FT                   coelicolor, wblE gene product (85 aa). Equivalent to
FT                   Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL
FT                   REGULATOR WHIB7 from Mycobacterium leprae (89 aa), FASTA
FT                   scores: opt: 441, E(): 6.3e-24, (69.3% identity in 88 aa
FT                   overlap). Similar to Q9FCJ8|2SC3B6.14 PUTATIVE DNA-BINDING
FT                   PROTEIN from Streptomyces coelicolor (122 aa), FASTA
FT                   scores: opt: 348, E(): 2.2e-17, (57.7% identity in 78 aa
FT                   overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from
FT                   Streptomyces coelicolor (102 aa), FASTA scores: opt: 166,
FT                   E(): 7.1e-05, (39.4% identity in 76 aa overlap); etc."
FT                   /db_xref="GOA:Q6MX01"
FT                   /db_xref="InterPro:IPR003482"
FT                   /db_xref="UniProtKB/TrEMBL:Q6MX01"
FT                   /protein_id="CAE55564.1"
FT                   /translation="MSVLTVPRQTPRQRLPVLPCHVGDPDLWFADTPAGLEVAKTLCVS
FT                   CPIRRQCLAAALQRAEPWGVWGGEIFDQGSIVSHKRPRGRPRKDAVA"
FT   CDS             complement(101446..103548)
FT                   /transl_table=11
FT                   /gene="uvrD2"
FT                   /locus_tag="Rv3198c"
FT                   /product="PROBABLE ATP-DEPENDENT DNA HELICASE II UVRD2"
FT                   /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR. HAS BOTH
FT                   ATPASE AND HELICASE ACTIVITIES. UNWINDS DNA DUPLEXES WITH
FT                   3' TO 5' POLARITY WITH RESPECT TO THE BOUND STRAND AND
FT                   INITIATES UNWINDING MOST EFFECTIVELY WHEN A SINGLE-STRANDED
FT                   REGION IS PRESENT. INVOLVED IN THE POSTINCISION EVENTS OF
FT                   NUCLEOTIDE EXCISION REPAIR AND METHYL-DIRECTED MISMATCH
FT                   REPAIR."
FT                   /EC_number="3.6.1.-"
FT                   /note="Rv3198c, (MTV014.42c), len: 700 aa. Probable UvrD2,
FT                   ATP dependent DNA helicase II (EC 3.6.1.-) (see citation
FT                   below), equivalent to
FT                   P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 PROBABLE DNA
FT                   HELICASE II HOMOLOG from Mycobacterium leprae (714 aa),
FT                   FASTA scores: opt: 3749, E(): 0, (82.85% identity in 706 aa
FT                   overlap); and C-terminal half (466-700 aa) corresponds to
FT                   Q49764|RECQ|B1937_F2_66 PUTATIVE DNA HELICASE RECQ (EC
FT                   3.6.1.-) (242 aa), FASTA scores: opt: 1267, E(): 1.4e-69,
FT                   (82.5% identity in 234 aa overlap); products of two
FT                   adjacent ORFS in Mycobacterium leprae. Also similar to
FT                   other DNA helicases e.g. Q9FCK0|2SC3B6.12 from Streptomyces
FT                   coelicolor (785 aa), FASTA scores: opt: 1687, E(): 1.2e-94,
FT                   (52.05% identity in 728 aa overlap);
FT                   P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-DEPENDENT
FT                   DNA HELICASE PCRA from Mycobacterium tuberculosis (771 aa),
FT                   FASTA scores: opt: 715, E(): 1e-35, (34.1% identity in 710
FT                   aa overlap); Q9CD72|PCRA_MYCLE|UVRD|ML0153 ATP-DEPENDENT
FT                   DNA HELICASE PCRA from Mycobacterium leprae (778 aa), FASTA
FT                   scores: opt: 687, E(): 5.1e-34, (32.0% identity in 719 aa
FT                   overlap); O83991|TP1028 DNA HELICASE II (UVRD) from
FT                   Treponema pallidum (670 aa), FASTA scores: opt: 652, E():
FT                   6e-32, (30.25% identity in 671 aa overlap); etc. Contains
FT                   PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO
FT                   THE UVRD SUBFAMILY OF HELICASES. TBparse score is 0.903."
FT                   /db_xref="GOA:P64320"
FT                   /db_xref="HSSP:1PJR"
FT                   /db_xref="InterPro:IPR002121"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64320"
FT                   /protein_id="CAA16663.1"
FT                   /translation="MSIASDPLIAGLDDQQREAVLAPRGPVCVLAGAGTGKTRTITHRI
FT                   ASLVASGHVAAGQVLAVTFTQRAAGEMRSRLRALDAAARTGSGVGAVQALTFHAAAYRQ
FT                   LRYFWSRVIADTGWQLLDSKFAVVARAASRTRLHASTDDVRDLAGEIEWAKASLIGPEE
FT                   YVTAVAAARRDPPLDAAQIAAVYSEYEALKARGDGVTLLDFDDLLLHTAAAIENDAAVA
FT                   EEFQDRYRCFVVDEYQDVTPLQQRVLSAWLGDRDDLTVVGDANQTIYSFTGASPRFLLD
FT                   FSRRFPDAAVVRLERDYRSTPQVVSLANRVIAAARGRVAGSKLRLSGQREPGPVPSFHE
FT                   HSDEPAEAATVAASIARLIASGTPPSEVAILYRVNAQSEVYEEALTQAGIAYQVRGGEG
FT                   FFNRQEIKQALLALQRVSERDTDAALSDVVRAVLAPLGLTAQPPVGTRARERWEALTAL
FT                   AELVDDELAQRPALQLPGLLAELRRRAEARHPPVVQGVTLASLHAAKGLEWDAVFLVGL
FT                   ADGTLPISHALAHGPNSEPVEEERRLLYVGITRARVHLALSWALSRSPGGRQSRKPSRF
FT                   LNGIAPQTRADPVPGTSRRNRGAAARCRICNNELNTSAAVMLRRCETCAADVDEELLLQ
FT                   LKSWRLSTAKEQNVPAYVVFTDNTLIAIAELLPTDDAALIAIPGIGARKLEQYGSDVLQ
FT                   LVRGRT"
FT   misc_feature    complement(103435..103458)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             103672..103926
FT                   /transl_table=11
FT                   /locus_tag="Rv3198A"
FT                   /product="POSSIBLE GLUTAREDOXIN PROTEIN"
FT                   /function="UNKNOWN"
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv3198A, len: 84 aa. Possible glutaredoxin protein
FT                   (EC 1.-.-.-), highly similar to Q9FCK1|2SC3B6.11c PUTATIVE
FT                   GLUTAREDOXIN-LIKE PROTEIN from Streptomyces coelicolor (80
FT                   aa), FASTA scores: opt: 293, E(): 2.2e-14, (55.15% identity
FT                   in 78 aa overlap); and Q9RSN9|DR2085 PUTATIVE GLUTAREDOXIN
FT                   from Deinococcus radiodurans (81 aa), FASTA scores: opt:
FT                   198, E(): 1.2e-07, (53.55% identity in 56 aa overlap). Also
FT                   similar to several hypothetical bacterial proteins e.g.
FT                   Q9X8C2|SCE36.09 HYPOTHETICAL 13.0 KDA PROTEIN from
FT                   Streptomyces coelicolor (114 aa), FASTA scores: opt: 181,
FT                   E(): 2.6e-06, (44.45% identity in 72 aa overlap)."
FT                   /db_xref="GOA:Q8VJ51"
FT                   /db_xref="InterPro:IPR012335"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q8VJ51"
FT                   /protein_id="CAE55565.1"
FT                   /translation="MITAALTIYTTSWCGYCLRLKTALTANRIAYDEVDIEHNRAAAEF
FT                   VGSVNGGNRTVPTVKFADGSTLTNPSADEVKAKLVKIAG"
FT   CDS             complement(103939..104880)
FT                   /transl_table=11
FT                   /gene="nudC"
FT                   /locus_tag="Rv3199c"
FT                   /product="PROBABLE NADH PYROPHOSPHATASE NUDC (NAD+
FT                   DIPHOSPHATASE) (NAD+ PYROPHOSPHATASE) (NADP
FT                   PYROPHOSPHATASE)"
FT                   /function="INVOLVED IN NICOTINATE AND NICOTINAMIDE
FT                   METABOLISM. GENERATES AMP AND NMN FROM NAD(+) AND H(2)O.
FT                   ACTING ON ACID ANHYDRIDES, IN PHOSPHORUS-CONTAINING
FT                   ANHYDRIDES. ALSO ACTS ON NADP+, 3-ACETYLPYRIDINE AND THE
FT                   THIONICOTINAMIDE ANALOGUES OF NAD+ AND NADP+ [CATALYTIC
FT                   ACTIVITY: NADH + H(2)O = AMP + NMNH]."
FT                   /EC_number="3.6.1.22"
FT                   /note="Rv3199c, (MTV014.43)c, len: 313 aa. Probable nudC,
FT                   NADH pyrophosphatase (EC 3.6.1.22), similar in particular
FT                   to Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356 aa),
FT                   FASTA scores: opt: 493, E(): 7.4e-24, (39.65% identity in
FT                   232 aa overlap); Q9ABG1|CC0266 MUTT/NUDIX FAMILY PROTEIN
FT                   from Caulobacter crescentus (313 aa), FASTA scores: opt:
FT                   479, E(): 5.1e-23, (38.3% identity in 222 aa overlap);
FT                   O86062|NUDC_PSEAE|NUDC|PA1823 NADH PYROPHOSPHATASE from
FT                   Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 371,2
FT                   E(): 3e-16, (43.15% identity in 153 aa overlap);
FT                   Q9RV62|NUDC_DEIRA|NUDC|DR1168 NADH PYROPHOSPHATASE from
FT                   Deinococcus radiodurans (280 aa), FASTA scores: opt: 363,
FT                   E(): 9.6e-16, (34.45% identity in 270 aa overlap); etc.
FT                   Caution: equivalent to AAK47636 from Mycobacterium
FT                   tuberculosis strain CDC1551 (386 aa) but shorter 72 aa.
FT                   Contains PS00893 mutT domain signature. BELONGS TO THE
FT                   NUDIX HYDROLASE FAMILY, NUDC SUBFAMILY. COFACTOR: REQUIRES
FT                   DIVALENT IONS: MANGANESE OR MAGNESIUM. TBparse score is
FT                   0.906."
FT                   /db_xref="GOA:O53345"
FT                   /db_xref="InterPro:IPR015376"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53345"
FT                   /protein_id="CAA16664.1"
FT                   /translation="MTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALL
FT                   RVDSRNRVLVANGRVLLGAAIELADKPPPEAVFLGRVEGGRHVWAVRAALQPIADPDIP
FT                   AEAVDLRGLGRIMDDTSSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNPITG
FT                   HEEFPRIDPAVICLVHDGADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREE
FT                   IGLTVRDVRYLGSQQWPFPRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALA
FT                   AGDWSSASESKLLLPGSISIARVIIESWAACE"
FT   misc_feature    complement(104215..104274)
FT                   /note="PS00893 mutT domain signature"
FT   CDS             complement(104939..106006)
FT                   /transl_table=11
FT                   /locus_tag="Rv3200c"
FT                   /product="POSSIBLE TRANSMEMBRANE CATION TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN CATION TRANSPORT
FT                   ACROSS THE MEMBRANE."
FT                   /note="Rv3200c, (MTV014.44c), len: 355 aa. Possible
FT                   transmembrane cation transporter, similar to many
FT                   transmembrane proteins and putative potassium channels e.g.
FT                   Q9XA52|SCGD3.27C PUTATIVE MEMBRANE PROTEIN from
FT                   Streptomyces coelicolor (365 aa), FASTA scores: opt: 1022,
FT                   E(): 2.6e-53, (49.85% identity in 325 aa overlap);
FT                   Q9RRZ3|DR2336 PUTATIVE POTASSIUM CHANNEL from Deinococcus
FT                   radiodurans (320 aa), FASTA scores: opt: 436, E(): 1e-18,
FT                   (30.9% identity in 304 aa overlap); O28600|AF1673 PUTATIVE
FT                   POTASSIUM CHANNEL from Archaeoglobus fulgidus (314 aa),
FT                   FASTA scores: opt: 363, E(): 2.1e-14, (27.2% identity in
FT                   309 aa overlap); Q57604|Y13B_METJAMJ0138.1|MJ0138.1
FT                   PUTATIVE POTASSIUM CHANNEL from Methanococcus jannaschii
FT                   (333 aa), FASTA scores: opt: 356, E(): 5.7e-14, (26.0%
FT                   identity in 281 aa overlap); P73132|SLL0993 POTASSIUM
FT                   CHANNEL from Synechocystis sp. strain PCC 6803 (365 aa),
FT                   FASTA scores: opt: 330, E(): 2.1e-12, (27.8% identity in
FT                   324 aa overlap); etc. Contains PS00017 ATP/GTP-binding site
FT                   motif A (P-loop). TBparse score is 0.904."
FT                   /db_xref="GOA:O53346"
FT                   /db_xref="HSSP:1LNQ"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O53346"
FT                   /protein_id="CAA16665.1"
FT                   /translation="MAGSWRRLRGLNEKLTAQPGYALVGVLRIPQRRASPARVISRRVV
FT                   VAVVALLLTAGIVYVDRDGYLDAQGDRLTFLDCLYYAAVTLSTTGYGDITPISEFARAI
FT                   NIFVITPLRIAFLILLVGTTLEVLTETSRQAYKIQRWRSRVRNHTVVIGYGTKGKTAVA
FT                   AMVSDELVPGEIVVVDTDSGVLERAAAAGLVTVHGDATKSDVLRLAGTQHASSIIVATS
FT                   RDDTAVLVTLTAREIAPKAKIVASIREAENQHLLRQSGADTVVVSSETAGRLLGIATTT
FT                   PSVVEMIEDLLTPEAGLAVAEREVEQAEVGGSPRHLRDIVLGVVRDGQLLRIGAPEVDA
FT                   IEASDRLLYIRQVGR"
FT   misc_feature    complement(105527..105550)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(106068..109373)
FT                   /transl_table=11
FT                   /locus_tag="Rv3201c"
FT                   /product="PROBABLE ATP-DEPENDENT DNA HELICASE"
FT                   /function="HAS BOTH ATPASE AND HELICASE ACTIVITIES"
FT                   /EC_number="3.6.1.-"
FT                   /note="Rv3201c, (MTV014.45c), len: 1101 aa. Probable
FT                   ATP-dependent DNA helicase (EC 3.6.1.-), similar to others
FT                   e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222
FT                   aa), FASTA scores: opt: 1209, E(): 5.4e-63, (38.45%
FT                   identity in 1199 aa overlap);
FT                   P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from
FT                   Mycobacterium tuberculosis (771 aa), FASTA scores: opt:
FT                   403, E(): 6.5e-16, (28.15% identity in 717 aa overlap);
FT                   Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159 aa),
FT                   FASTA scores: opt: 349, E(): 1.3e-12, (29.2% identity in
FT                   1144 aa overlap); Q9L3M1|UVRD from Prochlorococcus sp. (512
FT                   aa; fragment), FASTA scores: opt: 290, E(): 2e-09, (27.95%
FT                   identity in 479 aa overlap); etc. Contains PS00017
FT                   ATP/GTP-binding site motif A (P-loop). TBparse score is
FT                   0.909."
FT                   /db_xref="GOA:O53347"
FT                   /db_xref="HSSP:1PJR"
FT                   /db_xref="InterPro:IPR014017"
FT                   /db_xref="UniProtKB/TrEMBL:O53347"
FT                   /protein_id="CAA16666.1"
FT                   /translation="MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVIAGA
FT                   GAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGIGLGCGD
FT                   PAACAPVVSTYHAFAGSLLRDYGLLLPLEPDTRLLSETELWQLAFDVVSGYDGVLCTDK
FT                   SPAAVTSIVVRLWGQLGEHLVDTRALRDTHVELERLVHALPAGRYQRDRGPSQWLLRML
FT                   ATQTQRAELVPLLDALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLD
FT                   EYQDTGHAQRVVLSSLFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPLSD
FT                   GTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRALRPRPDAPPGAVRCALLPDV
FT                   QAEREWIADHLRMRYQRAEADGVKPPTAAVLVRRNADAAAIADTLRARGIPAEVVGLAG
FT                   LLSIPEVAEVVAMLRLVADPTAGAAAMRVLTGPRWRLGARDLAALWRRALTLSGESPST
FT                   ASPESIAMAASADADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRLGHSLP
FT                   DLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAERASARSSEASVAGLL
FT                   AYLDVAEVVENGLPPAELTVACDRVQVLTVHAAKGLEWQVVAVAHLSRGVFPSTVSRSS
FT                   WLTDPAELPPLLRGDRASAGAHGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERR
FT                   LLYVAVTRAEDTLLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWAS
FT                   APAGDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDIDHPPRP
FT                   GDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDPVGARQRLMCRLPKRP
FT                   DPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADREVGDPEELAALQRAFTASSWAART
FT                   PAAVEVPFEMPIGDTVVRGRIDAVFVDPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVY
FT                   RLAWAALRGCPTSSVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT"
FT   misc_feature    complement(109224..109247)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(109370..112537)
FT                   /transl_table=11
FT                   /locus_tag="Rv3202c"
FT                   /product="POSSIBLE ATP-DEPENDENT DNA HELICASE"
FT                   /function="HAS BOTH ATPASE AND HELICASE ACTIVITIES"
FT                   /EC_number="3.6.1.-"
FT                   /note="Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa.
FT                   Possible ATP-dependent DNA helicase (EC 3.6.1.-), showing
FT                   some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07
FT                   PUTATIVE ATP-DEPENDENT DNA HELICASE from Streptomyces
FT                   coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29,
FT                   (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443
FT                   MISMATCH REPAIR PROTEIN MUTU (DNA HELICASE II) from
FT                   Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239,
FT                   E(): 7.3e-06, (23.8% identity in 677 aa overlap) (no
FT                   similarity in C-terminal part for this one); etc.
FT                   C-terminal region similar to Q9FDU2|ORF3 ORF3 PROTEIN
FT                   (FRAGMENT) from Streptomyces griseus (551 aa), FASTA
FT                   scores: opt: 800, E(): 1.7e-37, (36.2% identity in 525 aa
FT                   overlap); and Q9ZG15 HYPOTHETICAL 35.5 KDA PROTEIN from
FT                   Rhodococcus erythropolis (323 aa), FASTA scores: opt: 232,
FT                   E(): 9.7e-06, (28.55% identity in 266 aa overlap)."
FT                   /db_xref="GOA:O53348"
FT                   /db_xref="HSSP:3PJR"
FT                   /db_xref="InterPro:IPR014017"
FT                   /db_xref="UniProtKB/TrEMBL:O53348"
FT                   /protein_id="CAA16669.1"
FT                   /translation="MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLVEAAVAHIGA
FT                   GTDPESVLLLTGSGRMGMRARSALTTALLRSRTNGPCRAAIREPVVRTVHSYAYAVLRK
FT                   AAQRAGDALPRLLTSAEQDAIIRELLAGDAEDGPAATTTWPAHLRPALTTAGFATELRN
FT                   LLARCAERGLDPLELQQLGRRRGRPEWIAAGQFAQRYEQVMLLRGAVGLAAPQATAPAL
FT                   SAAELVGAALEAFAVDPELLAAERARVRTLLVDDAQQLDPQAARLVRMLAAGTELALIA
FT                   GDPNQAVFGFRGGEPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGIARRLPG
FT                   RSVGRRIEGTGTEVGSVTVRLAGSAHAEAAMIADALRRAHLIDGVPWSQMAVIVRSVPR
FT                   AVRLPRALAAAGVPVAPPAVGGPLSAEPAVRALLTVLEATADGLDGDQALLLLTGPIGG
FT                   VDPVSLRQLRRTLQRARPGQTSRKFGDLLVEVLGGDAPPSGPGSRALRRVRAVLTAAAR
FT                   CHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAAVQATRDLETVTALFDITDH
FT                   YVSRTSGASLRGLVEHVTALQLPVVRPEPAAPTEQVMVLSAHAALGHEWDLVVIAGLQD
FT                   GLWPNTVPRGGVLGTQRLLDELDGVTKDASMRAPLLAEERRLLVTAMGRARRRLLVTAV
FT                   DSDAGGGGHEAVLPSAFFFEIAQWADGDGEPVAMQPVSAPRVLSAAAVVGRLRVVVCAP
FT                   ACAVDDADRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLCDSDDLVTLTPSTLQ
FT                   ALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRSESQLLAELDRVWGHLPFGA
FT                   QWYSANELARHRAMIQAFVQWRAQSRSELTEVGVEVDIDGALEDGSGQARKIRLRGRAD
FT                   RLERDPAGRLVIVDIKTGKTPVSKDDAQQHAQLAMYQLAVAEGLVRAGDEPGGARLVYV
FT                   GKSGAAGVAERKQDPLTPAARDEWRNLVRQLAAATAGPQFIARRNDGCTHCPLRPGCPA
FT                   HVRGSAP"
FT   CDS             112975..113649
FT                   /transl_table=11
FT                   /gene="lipV"
FT                   /locus_tag="Rv3203"
FT                   /product="POSSIBLE LIPASE LIPV"
FT                   /function="UNKNOWN; PRESUMED LIPOLYTIC ENZYME INVOLVED IN
FT                   CELLULAR METABOLISM."
FT                   /EC_number="3.1.-.-"
FT                   /note="Rv3203, (MTCY07D11.23c), len: 224 aa. Possible lipV,
FT                   hydrolase lipase (EC 3.1.-.-), showing some similarity to
FT                   other lipases e.g. Q9JSN0|NMA2216 PUTATIVE HYDROLASE from
FT                   Neisseria meningitidis (serogroup A) (312 aa), FASTA
FT                   scores: opt: 192, E(): 0.00016, (45.2% identity in 73 aa
FT                   overlap); Q9RK95|SCF1.09 PUTATIVE HYDROLASE from
FT                   Streptomyces coelicolor (258 aa), FASTA scores: opt: 188,
FT                   E(): 0.00024, (30.1% identity in 226 aa overlap);
FT                   Q9KZC3|SC6F7.19c PUTATIVE LIPASE from Streptomyces
FT                   coelicolor (269 aa), FASTA scores: opt: 179, E(): 0.00086,
FT                   (36.35% identity in 121 aa overlap); etc. Equivalent to
FT                   AAK47641 Hydrolase, alpha/beta hydrolase family from
FT                   Mycobacterium tuberculosis strain CDC1551 (261 aa) but
FT                   shorter 37 aa. Contains serine active site signature of
FT                   lipases (PS00120)."
FT                   /db_xref="GOA:O05863"
FT                   /db_xref="InterPro:IPR000639"
FT                   /db_xref="UniProtKB/TrEMBL:O05863"
FT                   /protein_id="CAB08320.1"
FT                   /translation="MPEIPIAAPDLLGHGRSPWAAPWTIDANVSALAALLDNQGDGPVV
FT                   VVGHSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDAMLASPDYLDPAEAR
FT                   AEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRISLPAMVCYWSELARDIVLPPVGT
FT                   ATTLVRAVRASPAYVSDQLLAALDKRLGADFELLDFDCGHMVPQAKPTEVAAVIRSRLG
FT                   PR"
FT   misc_feature    113104..113133
FT                   /note="PS00120 Lipases, serine active site"
FT   CDS             113652..113957
FT                   /transl_table=11
FT                   /locus_tag="Rv3204"
FT                   /product="POSSIBLE DNA-METHYLTRANSFERASE (MODIFICATION
FT                   METHYLASE)"
FT                   /function="CAUSES METHYLATION."
FT                   /EC_number="2.1.1.-"
FT                   /note="Rv3204, (MTCY07D11.22c), len: 101 aa. Possible DNA
FT                   methyltransferase (EC 2.1.1.-), similar to many
FT                   hypothetical bacteriel proteins and methyltransferases e.g.
FT                   Q9KT40|VC1065 METHYLATED-DNA--PROTEIN-CYSTEINE
FT                   METHYLTRANSFERASE-RELATED PROTEIN from Vibrio cholerae (100
FT                   aa), FASTA scores: opt: 170, E(): 2.8e-05, (34.35% identity
FT                   in 99 aa overlap); Q9UTN9|SPAC1250.04c PUTATIVE
FT                   METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission
FT                   yeast) (108 aa), FASTA scores: opt: 161, E(): 0.00013,
FT                   (36.65% identity in 101 aa overlap); Q9YDF4|APE0959 175 AA
FT                   LONG HYPOTHETICAL METHYLATED-DNA--PROTEIN-CYSTEINE
FT                   METHYLTRANSFERASE from Aeropyrum pernix (175 aa), FASTA
FT                   scores: opt: 144, E(): 0.003, (37.95% identity in 87 aa
FT                   overlap); Q50855 PUTATIVE METHYLGUANINE-DNA
FT                   METHYLTRANSFERASE from Myxococcus xanthus (147 aa), FASTA
FT                   scores: opt: 141, E(): 0.0041, (37.65% identity in 93 aa
FT                   overlap); etc."
FT                   /db_xref="GOA:O05862"
FT                   /db_xref="InterPro:IPR011991"
FT                   /db_xref="UniProtKB/TrEMBL:O05862"
FT                   /protein_id="CAB08312.1"
FT                   /translation="MAPVTDEQVELVRSLVAAIPLGRVSTYGDIAALTGLSSPRIVGWI
FT                   MRTDSSDLPWHRVIRASGRPAQHLATRQLELLRAEGVLSVDGRVALSEIRYEFPPG"
FT   CDS             complement(113964..114842)
FT                   /transl_table=11
FT                   /locus_tag="Rv3205c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3205c, (MTCY07D11.21), len: 292 aa. Hypothetical
FT                   protein, highly similar to Q9CCG7|ML0818 HYPOTHETICAL
FT                   PROTEIN from Mycobacterium leprae (297 aa), FASTA scores:
FT                   opt: 1745, E(): 9.1e-98, (87.3% identity in 291 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR013402"
FT                   /db_xref="UniProtKB/TrEMBL:O05861"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08311.1"
FT                   /translation="MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGEV
FT                   VLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPRHD
FT                   EVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGVPTA
FT                   PPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYWRPAS
FT                   WAAGVAVVDALSWGAADDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAEAFPGL
FT                   AHTAALVRLVL"
FT   CDS             complement(114869..116047)
FT                   /transl_table=11
FT                   /gene="moeB1"
FT                   /locus_tag="Rv3206c"
FT                   /standard_name="moeZ"
FT                   /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN
FT                   MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE
FT                   SULPHURYLASE)"
FT                   /function="POSSIBLY INVOLVED IN MOLYBDOPTERIN METABOLISM
FT                   (SYNTHESIS)"
FT                   /note="Rv3206c, (MTCY07D11.20), len: 392 aa. Probable
FT                   moeB1, molybdopterin cofactor biosynthesis protein,
FT                   equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED
FT                   IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae
FT                   (395 aa), FASTA scores: opt: 2285, E(): 3.3e-130, (86.45%
FT                   identity in 391 aa overlap.) Very similar to members of the
FT                   HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE
FT                   SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA
FT                   scores: opt: 1776, E(): 1.4e-99, (65.3% identity in 395 aa
FT                   overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE
FT                   SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas
FT                   perfectomarina) (391 aa), FASTA scores: opt: 1526, E():
FT                   1.5e-84, (59.1% identity in 391 aa overlap);
FT                   O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus
FT                   sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA
FT                   scores: opt: 1309, E(): 1.8e-71, (52.95% identity in 387 aa
FT                   overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS
FT                   MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392
FT                   aa), FASTA scores: opt: 1308, E(): 2e-71, (50.65% identity
FT                   in 397 aa overlap); etc. Also highly similar to
FT                   O05792|MOEB2|Rv3116|MTCY164.26 PUTATIVE MOLYBDENUM COFACTOR
FT                   BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (389
FT                   aa), FASTA scores: opt: 1440, E(): 2.3e-79, (57.25%
FT                   identity in 386 aa overlap). Has hydrophobic segment from
FT                   ~45-71. BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that
FT                   previously known as moeZ. Thought to be differentially
FT                   expressed within host cells (see citation below)."
FT                   /db_xref="GOA:Q7D5X9"
FT                   /db_xref="HSSP:1JWA"
FT                   /db_xref="InterPro:IPR007901"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D5X9"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55566.1"
FT                   /translation="MSTSLPPLVEPASALSREEVARYSRHLIIPDLGVDGQKRLKNARV
FT                   LVIGAGGLGAPTLLYLAAAGVGTIGIVDFDVVDESNLQRQVIHGVADVGRSKAQSARDS
FT                   IVAINPLIRVRLHELRLAPSNAVDLFKQYDLILDGTDNFATRYLVNDAAVLAGKPYVWG
FT                   SIYRFEGQASVFWEDAPDGLGVNYRDLYPEPPPPGMVPSCAEGGVLGIICASVASVMGT
FT                   EAIKLITGIGETLLGRLLVYDALEMSYRTITIRKDPSTPKITELVDYEQFCGVVADDAA
FT                   QAAKGSTITPRELRDWLDSGRKLALIDVRDPVEWDIVHIDGAQLIPKSLINSGEGLAKL
FT                   PQDRTAVLYCKTGVRSAEALAAVKKAGFSDAVHLQGGIVAWAKQMQPDMVMY"
FT   CDS             complement(116138..116995)
FT                   /transl_table=11
FT                   /locus_tag="Rv3207c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3207c, (MTCY07D11.19), len: 285 aa. Hypothetical
FT                   protein, highly similar but shorter (57 aa) to
FT                   Q9CCG9|ML0816 HYPOTHETICAL PROTEIN from Mycobacterium
FT                   leprae (341 aa), FASTA scores: opt: 1676, E(): 9.7e-96,
FT                   (81.0% identity in 284 aa overlap). Also similar to
FT                   C-terminus of Q9FBI6|SCP8.36 HYPOTHETICAL PROTEIN from
FT                   Streptomyces coelicolor (559 aa), FASTA scores: opt: 426,
FT                   E(): 8.4e-19, (37.35% identity in 281 aa overlap); and
FT                   similar to other hypothetical proteins (generally membrane
FT                   proteins) e.g. Q9K456|SC2H12.28C PUTATIVE MEMBRANE PROTEIN
FT                   from Streptomyces coelicolor (314 aa), FASTA scores: opt:
FT                   341, E(): 8.8e-14, (29.75% identity in 296 aa overlap).
FT                   Contains neutral zinc metallopeptidases, zinc-binding
FT                   region signature (PS00142)."
FT                   /db_xref="GOA:O05859"
FT                   /db_xref="InterPro:IPR006026"
FT                   /db_xref="UniProtKB/TrEMBL:O05859"
FT                   /protein_id="CAB08309.1"
FT                   /translation="MSTYGWRAYALPVLMVLTTVVVYQTVTGTSTPRPAAAQTVRDSPA
FT                   IGVVGTAILDAPPRGLAVFDANLPAGTLPDGGPFTEAGDKTWRVVPGTTPQVGQGTVKV
FT                   FRYTVEIENGLDPTMYGGDNAFAQMVDQTLTNPKGWTHNPQFAFVRIDSGKPDFRISLV
FT                   SPTTVRGGCGYEFRLETSCYNPSFGGMDRQSRVFINEARWVRGAVPFEGDVGSYRQYVI
FT                   NHEVGHAIGYLRHEPCDQQGGLAPVMMQQTFSTSNDDAAKFDPDFVKADGKTCRFNPWP
FT                   YPIP"
FT   misc_feature    complement(116306..116335)
FT                   /note="PS00142 Neutral zinc metallopeptidases, zinc-binding
FT                   region signature"
FT   CDS             117341..118027
FT                   /transl_table=11
FT                   /locus_tag="Rv3208"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   (PROBABLY TETR-FAMILY)"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv3208, (MTCY07D11.18c), len: 228 aa. Probable
FT                   transcriptional regulator, tetR family, equivalent to
FT                   Q9CCH0|ML0815 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL
FT                   REGULATOR from Mycobacterium leprae (228 aa), FASTA scores:
FT                   opt: 1248, E(): 1.4e-74, (82.4% identity in 227 aa
FT                   overlap). Also highly similar to Q9FBI8|SCP8.33c PUTATIVE
FT                   TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces
FT                   coelicolor (213 aa), FASTA scores: opt: 629, E(): 4e-34,
FT                   (45.8% identity in 203 aa overlap); Q9KIL9|F58R F58R
FT                   (FRAGMENT) from Streptomyces coelicolor A3(2) (149 aa),
FT                   FASTA scores: opt: 497, E(): 1.3e-25, (50.35% identity in
FT                   147 aa overlap); Q9K3T5|SCE66.08 PUTATIVE TETR-FAMILY
FT                   TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (225
FT                   aa), FASTA scores: opt: 344, E(): 1.8e-15, (31.15% identity
FT                   in 212 aa overlap); Q9RYK4|DRA0308 TRANSCRIPTIONAL
FT                   REGULATOR, TETR FAMILY from Deinococcus radiodurans (239
FT                   aa), FASTA scores: opt: 290, E(): 6.5e-12, (30.5% identity
FT                   in 223 aa overlap); etc. And also similar to Mycobacterium
FT                   tuberculosis proteins P96381|Rv1019|MTCY10G2.30c
FT                   HYPOTHETICAL 21.7 KDA PROTEIN (197 aa), FASTA scores: opt:
FT                   356, E(): 2.7e-16, (34.4% identity in 189 aa overlap);
FT                   MTV034_4; MTY07A7A_3; MTV032_1; MTCY07A7_12; etc. Contains
FT                   probable helix-turn-helix motif at aa 60-81 (Score 1517,
FT                   +4.35 SD). SIMILAR TO THE TETR/ACRR FAMILY OF
FT                   TRANSCRIPTIONAL REGULATORS."
FT                   /db_xref="GOA:O05858"
FT                   /db_xref="InterPro:IPR012287"
FT                   /db_xref="UniProtKB/TrEMBL:O05858"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08308.1"
FT                   /translation="MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQLL
FT                   VVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGVHQ
FT                   ALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCIDAV
FT                   FALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWGGLSH
FT                   VPLTRS"
FT   CDS             complement(118014..118286)
FT                   /transl_table=11
FT                   /gene="TB9.4"
FT                   /locus_tag="Rv3208A"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN TB9.4"
FT                   /function="UNKNOWN"
FT                   /note="Rv3208A, len: 90 aa. TB9.4, conserved hypothetical
FT                   protein (see citations below), equivalent to Q9CCH1|ML0814
FT                   HYPOTHETICAL PROTEIN from Mycobacterium leprae (82 aa),
FT                   FASTA scores: opt: 411, E(): 1.8e-22, (81.0% identity in 79
FT                   aa overlap). Also similar, but shorter in N-terminus, to
FT                   Q9FBI9|SCP8.32c PUTATIVE ATP-BINDING PROTEIN from
FT                   Streptomyces coelicolor (94 aa), FASTA scores: opt: 246,
FT                   E(): 8.1e-11, (53.4% identity in 73 aa overlap); Q9DGP6
FT                   (alias Q9DGP4) GLUTAMATE DECARBOXYLASE 67 KDA ISOFORM
FT                   (FRAGMENT) from Alepocephalus bairdii (182 aa), FASTA
FT                   scores: opt: 100, E(): 2.6, (35.3% identity in 85 aa
FT                   overlap). Corresponds to Statens Serum Institute antigen,
FT                   CYP10 TB9.4. Has N-terminal sequence, VEVKIGITDSPRELV."
FT                   /db_xref="UniProtKB/TrEMBL:Q6MWZ8"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55567.1"
FT                   /translation="MEVKIGITDSPRELVFSSAQTPSEVEELVSNALRDDSGLLTLTDE
FT                   RGRRFLIHTARIAYVEIGVADARRVGFGVGVDAAAGSAGKVATSG"
FT   CDS             118611..119171
FT                   /transl_table=11
FT                   /locus_tag="Rv3209"
FT                   /product="CONSERVED HYPOTHETICAL THREONIN AND PROLINE RICH
FT                   PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3209, (MTCY07D11.17c), len: 186 aa. Conserved
FT                   hypothetical thr-, pro-rich protein, equivalent (but
FT                   shorter 36 aa in N-terminus) to Q9CCH2|ML0813 PUTATIVE
FT                   MEMBRANE PROTEIN from Mycobacterium leprae (195 aa), FASTA
FT                   scores: opt: 508, E(): 1.4e-15, (58.4% identity in 185 aa
FT                   overlap). Also some similarity with
FT                   Q10390|MMS3_MYCTU|MMPS3|Rv2198c|MT2254|MTCY190.09c PROBABLE
FT                   CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from M.
FT                   tuberculosis (299 aa), FASTA scores: opt: 339, E():
FT                   3.7e-08, (35.0% identity in 180 aa overlap); and
FT                   Q9CCE9|MMPS3|ML0877 PUTATIVE MEMBRANE PROTEIN from
FT                   Mycobacterium leprae (293 aa), FASTA scores: opt: 272, E():
FT                   2.8e-05, (36.4% identity in 173 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O05857"
FT                   /protein_id="CAB08307.1"
FT                   /translation="MALGAVATAVIINSGDSTSTKAIVGAPAPRTVISTSPRPTAPTST
FT                   SPHPSPSTLRPQLPPETVTTVAPPGTGPTTVPTRTPTAAPPQTAVPPPAPLNPRTVVYR
FT                   VTGTKQLFDLVNVVYTDARGFPVTDFNVSLPWTKMVVLNPGVQTESVVATSLYSRLNCS
FT                   IVNTGAQTVVASTNNAIIATCTR"
FT   CDS             complement(119181..119876)
FT                   /transl_table=11
FT                   /locus_tag="Rv3210c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3210c, (MTCY07D11.16), len: 231 aa. Conserved
FT                   hypothetical protein, similar (but N-terminus shorter) to
FT                   Q9FBJ1|SCP8.30 CONSERVED HYPOTHETICAL PROTEIN from
FT                   Streptomyces coelicolor (260 aa), FASTA scores: opt: 599,
FT                   E(): 1.1e-30, (42.5% identity in 233 aa overlap); and some
FT                   similarity to Q9RRV1|DR2384 PHENYLACETIC ACID DEGRADATION
FT                   PROTEIN PAAC from Deinococcus radiodurans (263 aa), FASTA
FT                   scores: opt: 129, E(): 0.43, (27.9% identity in 172 aa
FT                   overlap); and Q9F621 FLGK PROTEIN from Rhizobium meliloti
FT                   (Sinorhizobium meliloti) (472 aa)."
FT                   /db_xref="GOA:O05856"
FT                   /db_xref="UniProtKB/TrEMBL:O05856"
FT                   /protein_id="CAB08306.1"
FT                   /translation="MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLTD
FT                   EARMAPDLRGRISMASMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLTTP
FT                   STWLEALVKTYVADALAADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAAVTA
FT                   SGKQRSRLALWSRRLLGEAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQQTHD
FT                   QRMRELGLS"
FT   CDS             120135..121718
FT                   /transl_table=11
FT                   /gene="rhlE"
FT                   /locus_tag="Rv3211"
FT                   /product="PROBABLE ATP-DEPENDENT RNA HELICASE RHLE"
FT                   /function="HAS A HELIX-DESTABILIZING ACTIVITY"
FT                   /note="Rv3211, (MTCY07D11.15c), len: 527 aa. Probable rhlE,
FT                   ATP-dependent RNA helicase, equivalent (but shorter 22 aa)
FT                   to Q9CCH3|RHLE|ML0811 PUTATIVE ATP-DEPENDENT RNA HELICASE
FT                   from Mycobacterium leprae (544 aa), FASTA scores: opt:
FT                   2497, E(): 8.7e-131, (74.75% identity in 531 aa overlap).
FT                   Also highly similar to other RNA helicases e.g.
FT                   Q9FBJ2|SCP8.29c from Streptomyces coelicolor (879 aa),
FT                   FASTA scores: opt: 1458, E(): 3.6e-73, (52.5% identity in
FT                   522 aa overlap); Q9DF36 from Xenopus laevis (African clawed
FT                   frog) (800 aa), FASTA scores: opt: 792, E(): 2.3e-36,
FT                   (37.15% identity in 385 aa overlap); Q99Z38|DEAD|SPY1415
FT                   from Streptococcus pyogenes (759 aa), FASTA scores: opt:
FT                   779, E(): 1.1e-35, (37.1% identity in 380 aa overlap);
FT                   P33906|DEAD|CSDA from Klebsiella pneumoniae (642 aa), FASTA
FT                   scores: opt: 768, E(): 4e-35, (43.4% identity in 387 aa
FT                   overlap); etc. Contains ATP/GTP-binding site motif A
FT                   (PS00017) and DEAD-box subfamily ATP-dependent helicases
FT                   signature (PS00039). SIMILAR TO DEAD/DEAH BOX HELICASE
FT                   FAMILY AND SIMILAR TO HELICASE C-TERMINAL DOMAIN."
FT                   /db_xref="GOA:O05855"
FT                   /db_xref="HSSP:1QDE"
FT                   /db_xref="InterPro:IPR014021"
FT                   /db_xref="UniProtKB/TrEMBL:O05855"
FT                   /protein_id="CAB08305.1"
FT                   /translation="MTAVKHTTESTFAKLGVRDEIVRALGEEGIKRPFAIQELTLPLAL
FT                   DGEDVIGQARTGMGKTFAFGVPLLQRITSGDGTRPLTGAPRALVVVPTRELCLQVTDDL
FT                   ATAGKYLTAGPDTDDAAAVRRRLSVVSIYGGRPYEPQIEALRAGADVVVGTPGRLLDLC
FT                   QQGHLQLGGLSVLVLDEADEMLDLGFLPDIERILRQIPADRQSMLFSATMPDPIITLAR
FT                   TFMVRPTHIRAEAPHSSAVHDATEQFVYRAHALDKVELVSRVLQARDRGATMIFTRTKR
FT                   TAQKVADELTERGFAVGAVHGDLGQLAREKALKAFRTGGIDVLVATDVAARGIDIDDVT
FT                   HVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELPRWSMIDQALGLGSPDPAET
FT                   YSNSPHLYAELAIPATAGGTVGPARKSQGRRRDTDCDGQKTAQHARNTPRRRRTRGGKP
FT                   VTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVVSGSRSGNGEAARRRRRRRRRPTH
FT                   AQDGFAARAN"
FT   misc_feature    120294..120317
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   misc_feature    120663..120689
FT                   /note="PS00039 DEAD-box subfamily ATP-dependent helicases
FT                   signature"
FT   CDS             121731..122954
FT                   /transl_table=11
FT                   /locus_tag="Rv3212"
FT                   /product="CONSERVED HYPOTHETICAL ALANINE VALINE RICH
FT                   PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3212, (MTCY07D11.14c), len: 407 aa. Hypothetical
FT                   ala-, val-rich protein, equivalent to Q9CCH4|ML0810
FT                   PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (407
FT                   aa), FASTA scores: opt: 2158, E(): 5.3e-119, (79.85%
FT                   identity in 407 aa overlap). Weak similarity to several
FT                   eukaryotic transcription factors e.g.
FT                   P08393|ICP0_HSV11|ICP0|IE110 TRANS-ACTING TRANSCRIPTIONAL
FT                   PROTEIN from Herpes simplex virus (type 1 / strain 17) (775
FT                   aa), FASTA scores: opt: 115, E(): 2, (26.9% identity in 334
FT                   aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O05854"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08304.1"
FT                   /translation="MVKPERRTKTDIAAAATIAVVVAVAASLIWWTSDARATISRPAAV
FT                   AVPTPAPAREVPTSLKQLWTAASPATRVPVVVGGTVATGDGRQVDGRDPATGESLWSYA
FT                   RDTDLCGVTWVYHYAVAVYRYDRGCGQVSTIDGSTGRRGAARSGYADPRVRLFSDGTTV
FT                   LSAGDTRLELWRSDMVRMLAYGEIDARVKPSNRGLQSGCTLESAAASSAAVSVLEACTN
FT                   QADLRLVLLRPGKEDDEPIQRIVPEPGVRPGSGARVLVVSQNNTAVYLPARSGAQPRVD
FT                   VIDETGATVSSTLLAKPPSTSAVASRTGNLVTWWTGDALLVFDAGNLTQRYTIAAGETT
FT                   APVGPGVMMAGQLLVPVTGGIGVYDPVSGANNRYIPVTRPPSTSAVIPAVSGSRVIEQR
FT                   GDTLVALG"
FT   CDS             complement(123029..123829)
FT                   /transl_table=11
FT                   /locus_tag="Rv3213c"
FT                   /product="POSSIBLE SOJ/PARA-RELATED PROTEIN"
FT                   /function="UNKNOWN, BUT POSSIBLY INVOLVED IN REGULATION OF
FT                   PARTITIONING."
FT                   /note="Rv3213c, (MTCY07D11.13), len: 266 aa. Possible
FT                   soj/parA-related protein, very similar in particular to
FT                   Soj/ParA proteins (and relatives) from Bacillus subtilis
FT                   that inhibit the initiation of sporulation by preventing
FT                   phosphorylation of Spo0A (see Quisel & Grossman 2000) e.g.
FT                   Q9S228|SCI51.12c from Streptomyces coelicolor (340 aa),
FT                   FASTA scores: opt: 746, E(): 1.6e-40, (48.2% identity in
FT                   249 aa overlap); Q9HT11|SOJ|PA5563 from Pseudomonas
FT                   aeruginosa (262 aa), FASTA scores: opt: 649, E(): 2.1e-34,
FT                   (42.2% identity in 256 aa overlap); Q9PB62|XF2282 from
FT                   Xylella fastidiosa (264 aa), FASTA scores: opt: 624, E():
FT                   8.3e-33, (42.25% identity in 251 aa overlap);
FT                   Q9K5N0|SOJ_BACHD|SOJ|BH4058 from Bacillus halodurans (253
FT                   aa), FASTA scores: opt: 621, E(): 1.2e-32, (41.55% identity
FT                   in 248 aa overlap); P37522|SOJ_BACSU (253 aa), FASTA
FT                   scores: opt: 620, E(): 1.4e-32, (41.65% identity in 245;
FT                   etc. Also similar to various mycobacterial proteins:
FT                   U00021_10 from Mycobacterium leprae, MTCI125_29 from
FT                   Mycobacterium tuberculosis, MLCB1351_6 from Mycobacterium
FT                   leprae, MTV028_9c|Rv3918c|PARA PROBABLE CHROMOSOME
FT                   PARTITIONING PROTEIN from Mycobacterium tuberculosis,
FT                   MSGDNAB_18 from Mycobacterium leprae. SEEMS TO BELONG TO
FT                   THE PARA FAMILY."
FT                   /db_xref="GOA:O05853"
FT                   /db_xref="InterPro:IPR002586"
FT                   /db_xref="UniProtKB/TrEMBL:O05853"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08303.1"
FT                   /translation="MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQG
FT                   CLTFSLGQDPDKLPVSVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMRAG
FT                   REYALKRALAKFSDRFDVVIIDCPPSLGVLTLNGLTAADKAIVPLQCEMLAHRGVGQFL
FT                   RTVADVQQITNPNLRLLGALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTVRFAE
FT                   ASASGSSVMAGRKNKGAVAYRELAQALLKHWKTGRPLPTFTVDL"
FT   repeat_region   complement(123830..123906)
FT                   /note="77 bp Mycobacterial Interspersed Repetitive Unit,
FT                   Class I"
FT   CDS             123983..124594
FT                   /transl_table=11
FT                   /gene="gpm2"
FT                   /locus_tag="Rv3214"
FT                   /standard_name="entD"
FT                   /product="POSSIBLE PHOSPHOGLYCERATE MUTASE GPM2
FT                   (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)"
FT                   /function="INVOLVED IN GLYCOLYSIS [CATALYTIC ACTIVITY:
FT                   1,3-DIPHOSPHOGLYCERATE + 3-PHOSPHOGLYCERATE =
FT                   2,3-DIPHOSPHOGLYCERATE + 3-PHOSPHOGLYCERATE]."
FT                   /EC_number="5.4.2.1"
FT                   /note="Rv3214, (MTCY07D11.12c), len: 203 aa. Possible gpm2,
FT                   phosphoglycerate mutase (EC 5.4.2.1), similar to many
FT                   mutases especially phosphoglycerate mutases e.g.
FT                   Q9F3H5|2SCC13.14c PUTATIVE MUTASE from Streptomyces
FT                   coelicolor (198 aa), FASTA scores: opt: 487, E(): 4.4e-25,
FT                   (42.25% identity in 194 aa overlap); BAB49378|MLL2186
FT                   PROBABLE PHOSPHOGLYCERATE MUTASE from Rhizobium loti
FT                   (Mesorhizobium loti) (193 aa), FASTA scores: opt: 423, E():
FT                   7e-21, (41.2% identity in 182 aa overlap); Q9RKV8|SC9G1.08c
FT                   PUTATIVE PHOSPHATASE from Streptomyces coelicolor (199 aa),
FT                   FASTA scores: opt: 419, E(): 1.3e-20, (41.1% identity in
FT                   185 aa overlap); Q9RDL0|SCC123.14c PUTATIVE
FT                   PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223
FT                   aa), FASTA scores: opt: 240, E(): 8.8e-09, (36.9% identity
FT                   in 168 aa overlap); Q9X194|TM1374 PHOSPHOGLYCERATE MUTASE
FT                   from Thermotoga maritima (201 aa), FASTA scores: opt: 218,
FT                   E(): 2.3e-07, (33.15% identity in 202 aa overlap); etc. But
FT                   N-terminus also similar to Q9CCH5|ENTC|ML0808 PUTATIVE
FT                   ISOCHORISMATE SYNTHASE from Mycobacterium leprae (577 aa),
FT                   FASTA scores: opt: 346, E(): 2.1e-15, (55.05% identity in
FT                   109 aa overlap). N-terminus shows also some similarity with
FT                   other M. tuberculosis proteins e.g. MTCY427.09c;
FT                   MTCY20G9.15; MTCY428.28. Equivalent to AAK47652 from
FT                   Mycobacterium tuberculosis strain CDC1551 (228 aa) but
FT                   shorter 25 aa. Note that previously known as entD."
FT                   /db_xref="GOA:Q6MWZ7"
FT                   /db_xref="InterPro:IPR013078"
FT                   /db_xref="PDB:2A6P"
FT                   /db_xref="UniProtKB/TrEMBL:Q6MWZ7"
FT                   /protein_id="CAE55568.1"
FT                   /translation="MGVRNHRLLLLRHGETAWSTLGRHTGGTEVELTDTGRTQAELAGQ
FT                   LLGELELDDPIVICSPRRRTLDTAKLAGLTVNEVTGLLAEWDYGSYEGLTTPQIRESEP
FT                   DWLVWTHGCPAGESVAQVNDRADSAVALALEHMSSRDVLFVSHGHFSRAVITRWVQLPL
FT                   AEGSRFAMPTASIGICGFEHGVRQLAVLGLTGHPQPIAAG"
FT   CDS             124591..125709
FT                   /transl_table=11
FT                   /gene="entC"
FT                   /locus_tag="Rv3215"
FT                   /product="PROBABLE ISOCHORISMATE SYNTHASE ENTC
FT                   (ISOCHORISMATE HYDROXYMUTASE) (ENTEROCHELIN BIOSYNTHESIS)"
FT                   /function="COULD BE INVOLVED IN ENTEROBACTIN BIOSYNTHESIS.
FT                   ENTEROBACTIN IS AN IRON-CHELATING COMPOUND INVOLVED IN
FT                   TRANSPORTING IRON FROM THE BACTERIAL ENVIRONMENT INTO THE
FT                   CELL CYTOPLASM. COULD BE ALSO INVOLVED IN
FT                   2,3-DIHYDROXYBENZOATE OR ENTEROCHELIN OR MENAQUINONE
FT                   BIOSYNTHESIS [CATALYTIC ACTIVITY: CHORISMATE =
FT                   ISOCHORISMATE]."
FT                   /EC_number="5.4.4.2"
FT                   /note="Rv3215, (MTCY07D11.11c), len: 372 aa. Probable entC,
FT                   isochorismate synthase (EC 5.4.99.6), equivalent to
FT                   Q9CCH5|ENTC|ML0808 PUTATIVE ISOCHORISMATE SYNTHASE from
FT                   Mycobacterium leprae (577 aa), FASTA scores: opt: 1817,
FT                   E(): 5.5e-105, (73.5% identity in 366 aa overlap). Also
FT                   similar to others e.g. Q9F639|MXCD PROTEIN INVOLVED IN
FT                   MYXOCHELIN-TYPE IRON CHELATOR BIOSYNTHESIS (see citation
FT                   below) from Stigmatella aurantiaca (408 aa), FASTA scores:
FT                   opt: 893, E(): 6.2e-48, (41.6% identity in 382 aa overlap);
FT                   P45744|DHBC_BACSU ISOCHORISMATE SYNTHASE from Bacillus
FT                   subtilis (398 aa), FASTA scores: opt: 883, E(): 2.5e-47,
FT                   (40.45% identity in 393 aa overlap); Q9KI93|CSBC
FT                   ISOCHORISMATE SYNTHASE (FRAGMENT) from Azotobacter
FT                   vinelandii (361 aa), FASTA scores: opt: 794, E(): 7.6e-42,
FT                   (45.65% identity in 298 aa overlap); and the two
FT                   Escherichia coli proteins AAG54928|ENTC (alias
FT                   BAB34055|ECS0632) ISOCHORISMATE HYDROXYMUTASE 2 from
FT                   Escherichia coli strain O157:H7 (391 aa), FASTA scores:
FT                   opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap);
FT                   P10377|ENTC|B0593 ISOCHORISMATE SYNTHASE from Escherichia
FT                   coli strain K12 (391 aa), FASTA scores: opt: 744, E():
FT                   1e-38, (38.8% identity in 340 aa overlap); etc. Stronger
FT                   similarity to Escherichia coli entC. Also similar to
FT                   MTCY253.35."
FT                   /db_xref="GOA:O05851"
FT                   /db_xref="HSSP:1K0G"
FT                   /db_xref="InterPro:IPR005801"
FT                   /db_xref="UniProtKB/TrEMBL:O05851"
FT                   /protein_id="CAB08301.1"
FT                   /translation="MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSG
FT                   TAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTRIG
FT                   RARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSAGND
FT                   DTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQL
FT                   VVDTMRVALEPLCEDLTIPAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTP
FT                   AVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHA
FT                   GGGIVAESDPDDELEETTTKFATILTALGVEQ"
FT   CDS             125857..126189
FT                   /transl_table=11
FT                   /locus_tag="Rv3216"
FT                   /product="POSSIBLE ACETYLTRANSFERASE"
FT                   /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM."
FT                   /EC_number="2.3.1.-"
FT                   /note="Rv3216, (MTCY07D11.10c), len: 110 aa. Possible
FT                   acetyltransferase (2.3.1.-), similar but shorter to many
FT                   e.g. Q9AB32|CC0402 ACETYLTRANSFERASE (GNAT FAMILY) from
FT                   Caulobacter crescentus (159 aa), FASTA scores: opt: 325,
FT                   E(): 3.8e-17, (45.65% identity in 103 aa overlap);
FT                   P79081|ATS1 PUTATIVE ACETYLTRANSFERASE ATS1 from
FT                   Schizosaccharomyces pombe (Fission yeast) (168 aa), FASTA
FT                   scores: opt: 313, E(): 3.1e-16, (47.6% identity in 105 aa
FT                   overlap); Q9I640|PA0478 PROBABLE N-ACETYLTRANSFERASE from
FT                   Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 308,
FT                   E(): 6.9e-16, (50.0% identity in 98 aa overlap); Q9KHE3
FT                   PUTATIVE ACETYLTRANSFERASE from Anabaena sp. strain PCC
FT                   7120 (164 aa), FASTA scores: opt: 269, E(): 5.4e-13,
FT                   (41.75% identity in 103 aa overlap); etc. Also some
FT                   similarity to diamine acetyltransferases (EC 2.3.1.57) e.g.
FT                   Q28999|ATDA_PIG|SAT from Sus scrofa (Pig) (171 aa), FASTA
FT                   scores: opt: 152, E(): 0.00025, (23.15% identity in 108 aa
FT                   overlap)."
FT                   /db_xref="GOA:O05850"
FT                   /db_xref="InterPro:IPR016181"
FT                   /db_xref="UniProtKB/TrEMBL:O05850"
FT                   /protein_id="CAB08300.1"
FT                   /translation="MRGHVAEVNGGVAAMALWFLNFSTWDGVAGIYVEDLFVWPRFRRR
FT                   GLARGLLSTLARECVDNRYTRLAWSVLNWNSDAIALYDRIGGQPQHEWTIYRLSGPRLA
FT                   ALAAPR"
FT   CDS             complement(126141..126572)
FT                   /transl_table=11
FT                   /locus_tag="Rv3217c"
FT                   /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3217c, (MTCY07D11.09), len: 143 aa. Probable
FT                   conserved integral membrane protein, equivalent (highly
FT                   similar but shorter 30 aa) to Q9CCH6|ML0806 PUTATIVE
FT                   MEMBRANE PROTEIN from Mycobacterium leprae (173 aa). Also
FT                   similar to others e.g. Q9F3L9|2SC7G11.04 PUTATIVE INTEGRAL
FT                   MEMBRANE PROTEIN from Streptomyces coelicolor (152 aa),
FT                   FASTA scores: opt: 177, E(): 0.00024, (33.8% identity in
FT                   136 aa overlap). And shows similarity to O34238|MVIN|VC0680
FT                   VIRULENCE FACTOR MVIN HOMOLOG from Vibrio (525 aa), FASTA
FT                   scores: opt: 126, E(): 0.97, (30.9% identity in 68 aa
FT                   overlap). First GTG taken."
FT                   /db_xref="UniProtKB/TrEMBL:O05849"
FT                   /protein_id="CAB08299.1"
FT                   /translation="MPVRAPAAVRGAGLIVAVQGGAALVVAAALLVRGLAGADQHIVNG
FT                   LGTAGWFVLVGGAVLAAGCRLAVGKLWGRGLAVFAQLLLLPVAWYLIVGSHQPAIGIPV
FT                   GIIALGVLVLLFSPPSIRWAAGRDQRGAASAANRGPDSR"
FT   CDS             126805..127770
FT                   /transl_table=11
FT                   /locus_tag="Rv3218"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3218, (MTCY07D11.08c), len: 321 aa. Conserved
FT                   hypothetical protein, similar to several hypothetical
FT                   bacterial proteins e.g. Q9F3M0|2SC7G11.03c from
FT                   Streptomyces coelicolor (322 aa), FASTA scores: opt: 694,
FT                   E(): 4.2e-35, (39.95% identity in 328 aa overlap);
FT                   Q9A0J4|SPY0752 from Streptomyces pyogenes (340 aa), FASTA
FT                   scores: opt: 187, E(): 0.00033, (30.5% identity in 141 aa
FT                   overlap); O31502|YERQ from Bacillus subtilis (303 aa),
FT                   FASTA scores: opt: 184, E(): 0.00045, (34.15% identity in
FT                   126 aa overlap); etc."
FT                   /db_xref="GOA:O05848"
FT                   /db_xref="InterPro:IPR001206"
FT                   /db_xref="UniProtKB/TrEMBL:O05848"
FT                   /protein_id="CAB08319.1"
FT                   /translation="MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGTE
FT                   LGQAAVADGVDLVVVHGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLARAL
FT                   GISADPIAATNQLIQLLDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVEAER
FT                   DKGGKVTAWRYIRAAVRAVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTYANNR
FT                   PVWTNPDCRFESGLGVFATTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVACLRVTS
FT                   MGPPIASQFDGDYLGVRETMTFRAVPDALAVVAPPARKRI"
FT   CDS             128050..128304
FT                   /transl_table=11
FT                   /gene="whiB1"
FT                   /locus_tag="Rv3219"
FT                   /standard_name="whmE"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   WHIB-LIKE WHIB1"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv3219, (MTCY07D11.07c), len: 84 aa. Probable whiB1
FT                   (alternate gene name: whmE), WhiB-like regulatory protein
FT                   (see citation below), similar to WhiB paralogue of
FT                   Streptomyces coelicolor. Equivalent to Q9CCH7|WHIB1|ML0804
FT                   PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium
FT                   leprae (84 aa), FASTA scores: opt: 580, E(): 3.5e-35,
FT                   (95.25% identity in 84 aa overlap). Highly similar to
FT                   several e.g. Q9X952|WBLE DEVELOPMENTAL REGULATORY PROTEIN
FT                   WHIB-PARALOG from Streptomyces coelicolor (85 aa), FASTA
FT                   scores: opt: 477, E(): 9.2e-28, (75.3% identity in 81 aa
FT                   overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from
FT                   Streptomyces coelicolor (102 aa), FASTA scores: opt: 383,
FT                   E(): 6.1e-21, (60.75% identity in 79 aa overlap);
FT                   Q9K4K8|SC5F8.16c from Streptomyces coelicolor (83 aa),
FT                   FASTA scores: opt: 346, E(): 2.5e-18, (54.75% identity in
FT                   84 aa overlap); etc."
FT                   /db_xref="InterPro:IPR003482"
FT                   /db_xref="UniProtKB/TrEMBL:O05847"
FT                   /protein_id="CAB08318.1"
FT                   /translation="MDWRHKAVCRDEDPELFFPVGNSGPALAQIADAKLVCNRCPVTTE
FT                   CLSWALNTGQDSGVWGGMSEDERRALKRRNARTKARTGV"
FT   CDS             complement(128366..129871)
FT                   /transl_table=11
FT                   /locus_tag="Rv3220c"
FT                   /product="PROBABLE TWO COMPONENT SENSOR KINASE"
FT                   /function="SENSOR PART OF A TWO COMPONENT REGULATORY
FT                   SYSTEM."
FT                   /EC_number="2.7.3.-"
FT                   /note="Rv3220c, (MTCY07D11.06), len: 501 aa. Probable
FT                   sensor (probably histidine kinase), equivalent to
FT                   Q9CCH8|ML0803 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE
FT                   from Mycobacterium leprae (500 aa). Similar to others e.g.
FT                   Q9F3M1|2SC7G11.01 PUTATIVE HISTIDINE KINASE (FRAGMENT) from
FT                   Streptomyces coelicolor (372 aa), FASTA scores: opt: 1038,
FT                   E(): 7.4e-56, (48.95% identity in 380 aa overlap);
FT                   Q9A3K5|CC3198 SENSOR HISTIDINE KINASE from Caulobacter
FT                   crescentus (327 aa), FASTA scores: opt: 311, E(): 1.2e-11,
FT                   (33.35% identity in 201 aa overlap) (similarity only in
FT                   C-terminal part for this one); Q9A2T2|CC3474 PUTATIVE
FT                   SENSOR HISTIDINE KINASE from Caulobacter crescentus (547
FT                   aa); etc. C-terminal half shows similarity to many sensor
FT                   proteins, that respond to various stimuli from
FT                   Methanobacterium thermoautotrophicum e.g. O26568|MTH468
FT                   SENSORY TRANSDUCTION HISTIDINE KINASE (554 aa), FASTA
FT                   scores: opt: 425, E(): 2.1e-18, (34.0% identity in 244 aa
FT                   overlap); O26546|MTH446 SENSORY TRANSDUCTION REGULATORY
FT                   PROTEIN (583 aa), FASTA scores: opt: 380, E(): 1.2e-15,
FT                   (37.15% identity in 202 aa overlap); O26913|MTH823 SENSORY
FT                   TRANSDUCTION REGULATORY PROTEIN (677 aa), FASTA scores:
FT                   opt: 375, E(): 2.7e-15, (35.4% identity in 195 aa overlap);
FT                   etc. SEEMS SIMILAR TO OTHER PROKARYOTIC SENSORY
FT                   TRANSDUCTION HISTIDINE KINASES."
FT                   /db_xref="GOA:O05846"
FT                   /db_xref="HSSP:1KZN"
FT                   /db_xref="InterPro:IPR013656"
FT                   /db_xref="UniProtKB/TrEMBL:O05846"
FT                   /protein_id="CAB08317.1"
FT                   /translation="MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVR
FT                   RDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQNSC
FT                   QHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEGTFP
FT                   DAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPL
FT                   ISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDV
FT                   TEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVS
FT                   SIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLDSDRATAL
FT                   IMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSL
FT                   GLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML"
FT   CDS             complement(129888..130103)
FT                   /transl_table=11
FT                   /gene="TB7.3"
FT                   /locus_tag="Rv3221c"
FT                   /product="BIOTINYLATED PROTEIN TB7.3"
FT                   /function="UNKNOWN"
FT                   /note="Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3,
FT                   Biotinylated protein (see citations below), equivalent
FT                   (appears to have one additional residue) to
FT                   Q9CCH9|ML0802|BTB7_MYCLE BIOTINYLATED PROTEIN TB7.3 HOMOLOG
FT                   from Mycobacterium leprae (70 aa), FASTA scores: opt: 367,
FT                   E(): 4e-18, (90.0% identity in 70 aa overlap);
FT                   Q9XCD6|BTB7_MYCSM BIOTINYLATED PROTEIN TB7.3 HOMOLOG from
FT                   Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341,
FT                   E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar
FT                   to C-terminal part of various proteins e.g.
FT                   Q9HPP8|ACC|VNG1532G BIOTIN CARBOXYLASE from Halobacterium
FT                   sp. strain NRC-1 (610 aa), FASTA scores: opt: 212, E():
FT                   4e-07, (50.0% identity in 68 aa overlap);
FT                   Q58628|PYCB_METJA|MJ1231 PYRUVATE CARBOXYLASE SUBUNIT B
FT                   from Methanococcus jannaschii (567 aa), FASTA scores: opt:
FT                   192, E(): 7.8e-06, (44.8% identity in 58 aa overlap);
FT                   Q9ZAA7|GCDC GLUTACONYL-CoA DECARBOXYLASE GAMMA SUBUNIT from
FT                   Acidaminococcus fermentans (145 aa), FASTA scores: opt:
FT                   184, E(): 8.9e-06, (39.4% identity in 66 aa overlap); etc."
FT                   /db_xref="HSSP:1IYU"
FT                   /db_xref="InterPro:IPR000089"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A510"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08316.1"
FT                   /translation="MAEDVRAEIVASVLEVVVNEGDQIDKGDVVVLLESMKMEIPVLAE
FT                   AAGTVSKVAVSVGDVIQAGDLIAVIS"
FT   CDS             complement(130388..130693)
FT                   /transl_table=11
FT                   /locus_tag="Rv3221A"
FT                   /product="POSSIBLE ANTI-SIGMA FACTOR"
FT                   /function="BINDS SIGMA FACTOR AND INHIBITS IT. PROBABLY
FT                   INVOLVED IN SURVIVAL FOLLOWING HEAT SHOCK AND OXIDATIVE
FT                   STRESS."
FT                   /note="Rv3221A, len: 101 aa. Possible anti-sigma factor,
FT                   similar to Q9XCD7|AAD41811.1 unknown protein from
FT                   Mycobacterium smegmatis, linked to sigma factor sigH (see
FT                   Fernandes et al., 1999) (101 aa), FASTA scores: opt: 422,
FT                   E(): 3.4e-22, (64.9% identity in 94 aa overlap); and to
FT                   Q9RL96|RsrA anti-sigma factor from Streptomyces coelicolor
FT                   (see Kang et al., 1999) (105 aa), FASTA scores: opt: 163,
FT                   E(): 0.00016, (32.05% identity in 78 aa overlap)."
FT                   /db_xref="InterPro:IPR014295"
FT                   /db_xref="UniProtKB/TrEMBL:Q8VJ46"
FT                   /protein_id="CAE55569.1"
FT                   /translation="MSENCGPTDAHADHDDSHGGMGCAEVIAEVWTLLDGECTPETRER
FT                   LRRHLEACPGCLRHYGLEERIKALIGTKCRGDRAPEGLRERLRLEIRRTTIIRGGP"
FT   CDS             complement(130690..131241)
FT                   /transl_table=11
FT                   /locus_tag="Rv3222c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical
FT                   protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020
FT                   GLYCINE-RICH PROTEIN LIKE from Arabidopsis thaliana
FT                   (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E():
FT                   0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18
FT                   PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces
FT                   coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,
FT                   (36.25% identity in 149 aa overlap); etc. Also some
FT                   similarity to other hypothetical Mycobacterium tuberculosis
FT                   proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA
FT                   scores: opt: 141, E(): 0.5, (31.2% identity in 170 aa
FT                   overlap); AAK45760|MT1497.1 PE_PGRS FAMILY PROTEIN from
FT                   strain CDC1551 (1408 aa), FASTA scores: opt: 137, E(): 2,
FT                   (31.75% identity in 148 aa overlap); etc."
FT                   /db_xref="UniProtKB/TrEMBL:O05844"
FT                   /protein_id="CAB08315.1"
FT                   /translation="MSSPVSSRRLANLVKESLQGSVLGGVVSDAVLPAVSDDVKPGAGE
FT                   DAYRVPVVVAAGSGAVVQVGGLEVGSAAVAGEVADTVAELFVCRPTEPDVGDFVGLAGG
FT                   AGDAGQAGQQFGLGVGVRGESFGARRRLALSTVGASGATAGLRKTHDGHHGCQARGALT
FT                   QRRLYIGNPSEITDTRMVHQ"
FT   CDS             complement(131238..131888)
FT                   /transl_table=11
FT                   /gene="sigH"
FT                   /locus_tag="Rv3223c"
FT                   /standard_name="rpoE"
FT                   /product="ALTERNATIVE RNA POLYMERASE SIGMA-E FACTOR
FT                   (SIGMA-24) SIGH (RPOE)"
FT                   /function="ALTERNATIVE SIGMA FACTOR THAT PLAYS A ROLE IN
FT                   THE OXIDATIVE-STRESS RESPONSE (REGULATION OF THIOREDOXIN
FT                   RECYCLING). THE SIGMA FACTOR IS AN INITIATION FACTOR THAT
FT                   PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC
FT                   INITIATION SITES AND THEN IS RELEASED. THIS SIGMA FACTOR IS
FT                   INVOLVED IN HEAT SHOCK AND OXIDATIVE STRESS RESPONSE; IT IS
FT                   BELIEVED TO CONTROL PROTEIN PROCESSING IN THE
FT                   EXTRACYTOPLASMIC COMPARTMENT. REGULATES POSITIVELY DNAK AND
FT                   CLPB GENES. REGULATES TRXB2, TRXC, Rv2466c AND SIGB GENES,
FT                   AND PROBABLY SIG B GENE. SIGH MAY MEDIATE THE TRANSCRIPTION
FT                   OF AT LEAST 31 GENES DIRECTLY AND MODULATES THE EXPRESSION
FT                   OF ABOUT 150 OTHERS."
FT                   /note="Rv3223c, (MTCY07D11.03), len: 216 aa. sigH
FT                   (alternate gene name: rpoE), alternative RNA polymerase
FT                   sigma factor (see citations below), similar to many e.g.
FT                   Q9XCD8|SIGH from Mycobacterium smegmatis (215 aa), FASTA
FT                   scores: opt: 1187, E(): 8.1e-69, (87.75% identity in 212 aa
FT                   overlap); O87834|SIGR from Streptomyces coelicolor (227
FT                   aa), FASTA scores: opt: 913, E(): 2.6e-51, (68.8% identity
FT                   in 202 aa overlap); O68520|RPOE1 from Myxococcus xanthus
FT                   (213 aa), FASTA scores: opt: 452, E(): 6.7e-22, (42.8%
FT                   identity in 187 aa overlap);
FT                   Q06198|RPSH_PSEAE|ALGU|ALGT|PA0762 from Pseudomonas
FT                   aeruginosa (193 aa), FASTA scores: opt: 301, E(): 2.7e-12,
FT                   (29.9% identity in 194 aa overlap); etc. Equivalent to
FT                   AAK47662 RNA polymerase sigma-70 factor from Mycobacterium
FT                   tuberculosis strain CDC1551 (284 aa), but shorter 68 aa.
FT                   Has sigma-70 factors ECF subfamily signature (PS01063). So
FT                   BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. Start
FT                   chosen on basis of similarity, other potential starts
FT                   upstream."
FT                   /db_xref="GOA:P66807"
FT                   /db_xref="HSSP:1OR7"
FT                   /db_xref="InterPro:IPR013249"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66807"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08314.1"
FT                   /translation="MADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGAL
FT                   RMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPAEY
FT                   PTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYADVEG
FT                   FPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS"
FT   misc_feature    complement(131691..131729)
FT                   /note="PS01063 Sigma-70 factors ECF subfamily signature"
FT   CDS             132188..133036
FT                   /transl_table=11
FT                   /locus_tag="Rv3224"
FT                   /product="POSSIBLE IRON-REGULATED SHORT-CHAIN
FT                   DEHYDROGENASE/REDUCTASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv3224, (MTCY07D11.02c), len: 282 aa. Probable
FT                   iron-regulated oxidoreductase, possible short-chain
FT                   dehydrogenase/reductase (EC 1.-.-.-), highly similar to
FT                   BAB49551|MLL2413 HYPOTHETICAL PROTEIN from Rhizobium loti
FT                   (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053,
FT                   E(): 6.4e-59, (57.95% identity in 276 aa overlap);
FT                   Q9AB34|CC0400 SHORT CHAIN DEHYDROGENASE FAMILY PROTEIN from
FT                   Caulobacter crescentus (285 aa), FASTA scores: opt: 1051,
FT                   E(): 8.5e-59, (55.9% identity in 281 aa overlap); and
FT                   Q9VB10|CG5590 HYPOTHETICAL PROTEIN (SIMILAR TO THE
FT                   SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from
FT                   Drosophila melanogaster (Fruit fly) (412 aa), FASTA scores:
FT                   opt: 966, E(): 2.5e-53, (52.15% identity in 278 aa
FT                   overlap). Similar to various proteins (principaly
FT                   oxidoreductases) e.g. Q18639|C45B11.3 HYPOTHETICAL PROTEIN
FT                   (SIMILAR TO THE SDR FAMILY) from Caenorhabditis elegans
FT                   (293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3%
FT                   identity in 271 aa overlap); Q9HZV5|PA2892 PROBABLE
FT                   SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (274
FT                   aa), FASTA scores: opt: 847, E(): 5.1e-46, (49.25% identity
FT                   in 274 aa overlap); Q9I6V0|PA0182 PROBABLE SHORT-CHAIN
FT                   DEHYDROGENASE (SIMILAR TO THE SDR FAMILY) from Pseudomonas
FT                   aeruginosa (250 aa), FASTA scores: opt: 333, E(): 8.3e-14,
FT                   (29.8% identity in 245 aa overlap); Q9HY98|PA3511 PROBABLE
FT                   SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (253
FT                   aa), FASTA scores: opt: 330, E(): 1.3e-13, (31.2% identity
FT                   in 250 aa overlap); etc. Related proteins in Mycobacterium
FT                   tuberculosis include MTCY02B10.14, MTCY369.14, and
FT                   MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017)
FT                   near C-terminus. MAY BE BELONG TO THE SHORT-CHAIN
FT                   DEHYDROGENASES/REDUCTASES (SDR) FAMILY."
FT                   /db_xref="GOA:O05842"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O05842"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08313.1"
FT                   /translation="MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPKL
FT                   PGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINLGS
FT                   ITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPILLEKKWLRPTAYM
FT                   MAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKPEVYAD
FT                   AAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLP
FT                   A"
FT   misc_feature    132881..132904
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             132972..133160
FT                   /transl_table=11
FT                   /locus_tag="Rv3224A"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3224A, len: 62 aa. Conserved hypothetical protein
FT                   (possibly gene fragment), overlaps Rv3224. Similar to
FT                   N-terminus of ML0799|AL583919_131 conserved hypothetical
FT                   protein from Mycobacterium leprae (135 aa), FASTA scores:
FT                   opt: 104, E(): 0.78, (59.37% identity in 32 aa overlap).
FT                   Note that upstream ORF Rv3224B is similar to C-terminus of
FT                   ML0799. There appears to be no frameshift as sequence is
FT                   identical in strain CDC1551 and in Mycobacterium bovis."
FT                   /db_xref="UniProtKB/TrEMBL:Q6MWZ5"
FT                   /protein_id="CAE55570.1"
FT                   /translation="MRRSASTCGWKTPTRRGTSRPSDSKTLILELPDERAVAIVPVPSK
FT                   LSLKAAGGPRGAQSGHG"
FT   CDS             133138..133356
FT                   /transl_table=11
FT                   /locus_tag="Rv3224B"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3224B, len: 72 aa. Conserved hypothetical protein
FT                   (possibly gene fragment), similar to C-terminal part of
FT                   ML0799|AL583919_131 conserved hypothetical protein from
FT                   Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E():
FT                   2e-09, (60.00% identity in 70 aa overlap). Note that
FT                   downstream ORF Rv3224A is similar to N-terminus of ML0799.
FT                   There appears to be no frameshift as sequence is identical
FT                   in strain CDC1551 and in Mycobacterium bovis."
FT                   /db_xref="InterPro:IPR007214"
FT                   /db_xref="UniProtKB/TrEMBL:Q6MWZ4"
FT                   /protein_id="CAE55571.1"
FT                   /translation="MPKAAMAKPAAAEQATGYVVGGISPFGQRKRLRTVVDVSALSWDR
FT                   VLRCRQTALGRHGGPAGPDHLDQRDHR"
FT   CDS             complement(133353..134777)
FT                   /transl_table=11
FT                   /locus_tag="Rv3225c"
FT                   /product="POSSIBLE TRANSFERASE"
FT                   /function="UNKNOWN"
FT                   /EC_number="2.-.-.-"
FT                   /note="Rv3225c, (MTCY07D11.01), len: 474 aa (start
FT                   uncertain). Possible transferase (EC 2.-.-.-). C-terminal
FT                   part shows some similarity to various bacterial proteins
FT                   e.g. BAB49093|MLL1809 HYPOTHETICAL PROTEIN from Rhizobium
FT                   loti (Mesorhizobium loti) (298 aa), FASTA scores: opt: 557,
FT                   E(): 2.8e-26, (34.55% identity in 295 aa overlap);
FT                   P14509|KKA8_ECOLI|APHA AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE
FT                   from Escherichia coli (271 aa), FASTA scores: opt: 194,
FT                   E(): 0.00018, (27.75% identity in 227 aa overlap);
FT                   Q53826|CPH CAPREOMYCIN PHOSPHOTRANSFERASE from Streptomyces
FT                   capreolus (281 aa), FASTA scores: opt: 178, E(): 0.0017,
FT                   (30.5% identity in 269 aa overlap); Q9CDM4|YWIA UNKNOWN
FT                   PROTEIN from Lactococcus lactis (subsp. lactis)
FT                   (Streptococcus lactis) (213 aa), FASTA scores: opt: 167,
FT                   E(): 0.0061, (2705% identity in 149 aa overlap);
FT                   Q9X843|SC9B1.24 PUTATIVE TRANSFERASE (FRAGMENT) from
FT                   Streptomyces coelicolor (317 aa), FASTA scores: opt: 165,
FT                   E(): 0.011, (26.05% identity in 280 aa overlap); etc."
FT                   /db_xref="GOA:O05841"
FT                   /db_xref="InterPro:IPR016181"
FT                   /db_xref="UniProtKB/TrEMBL:O05841"
FT                   /protein_id="CAB08321.1"
FT                   /translation="MRFAKLSDGLSDGIVTLSPLCLDDVDAHLAGGDERLVRWLSGMPS
FT                   TRASVEAYIRHCREQWVTGGPLRSFGIRTVAETIVGTIDLRFDGEGLASGQVNVAYGLY
FT                   PSWRGRGLATRAVDLVCQYAAEHGATEAVIKVEPENSASARVALRAGFAFVRRICEQDG
FT                   TVFDRYERVLRAKMHADEVDIDEDLVRRLLRAQFPQWADLPIAPVRSAGTDNAMYRLGE
FT                   DLAVRIPRIGWAIESLRTEQQWLPRIAAHLGVASPVPVGLGSPAEGFGWPWSVCRWVAG
FT                   ENPSAAEFVEPNRAVEDLADFITALRATDPMGGPPAKRGAPLGEQDAEVRAALAALDGI
FT                   IDVHAATAAWESALRVPPYAGPPMWFHGDLSRFNILTAQGRLTGVIDFGLMGVGDPSVD
FT                   LIIAWNLLSAPARAQFRVAVGAADDDWMRGRGRALAIALIALPYYQDTNPPLAASARYA
FT                   IGEVLADFRYGARPGC"
FT   CDS             complement(134901..135659)
FT                   /transl_table=11
FT                   /locus_tag="Rv3226c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3226c, (MTCY20B11.01c), len: 252 aa. Conserved
FT                   hypothetical protein, similar to various hypothetical
FT                   bacterial proteins e.g. Q9CCI2|ML0793 PUTATIVE
FT                   BACTERIOPHAGE PROTEIN from Mycobacterium leprae (252 aa),
FT                   FASTA scores: opt: 1183, E(): 3.8e-68, (70.65% identity in
FT                   252 aa overlap); BAB54183|MLR7795 HYPOTHETICAL PROTEIN from
FT                   Rhizobium loti (Mesorhizobium loti) (369 aa), FASTA scores:
FT                   opt: 417, E(): 2.9e-19, (33.75% identity in 252 aa
FT                   overlap); O64131 YOQW PROTEIN from Bacteriophage SPBc2 (224
FT                   aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity
FT                   in 244 aa overlap); O31916 YOQW PROTEIN from Bacillus
FT                   subtilis (224 aa), FASTA scores: opt: 413, E(): 3.4e-19,
FT                   (38.5% identity in 244 aa overlap); O34906 YOAM PROTEIN
FT                   from Bacillus subtilis (227 aa), FASTA scores: opt: 401,
FT                   E(): 2e-18, (37.7% identity in 244 aa overlap);
FT                   Q9K4A5|SC7E4.11 HYPOTHETICAL 30.8 KDA PROTEIN from
FT                   Streptomyces coelicolor (271 aa), FASTA scores: opt: 383,
FT                   E(): 3.3e-17, (39.6% identity in 283 aa overlap); etc."
FT                   /db_xref="InterPro:IPR003738"
FT                   /db_xref="UniProtKB/TrEMBL:O05872"
FT                   /protein_id="CAB08327.1"
FT                   /translation="MCGRFAVTTDPAQLAEKITAIDEATGCGGGKTSYNVAPTDTIATV
FT                   VSRHSEPDDEPTRRVRLMRWGLIPSWIKAGPGGAPDAKGPPLINARADKVATSPAFRSA
FT                   VRSKRCLVPMDGWYEWRVDPDATPGRPNAKTPFFLHRHDGALLFTAGLWSVWKSYRSAP
FT                   PLLSCTVITTDAVGELAEIHDRMPLLLAEEDWDDWLNPDAPPDPELLARPPDVRDIALR
FT                   QVSTLVNNVRNNGPELLEPARSQPEQIQLL"
FT   CDS             135714..137066
FT                   /transl_table=11
FT                   /gene="aroA"
FT                   /locus_tag="Rv3227"
FT                   /product="3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE AROA
FT                   (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP
FT                   SYNTHASE) (EPSPS)"
FT                   /function="INVOLVED IN THE BIOSYNTHESIS OF CHORISMATE
FT                   WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO ACIDS (THE
FT                   SHIKIMATE PATHWAY). ACTS IN THE SIXTH STEP OF THIS PATHWAY.
FT                   [CATALYTIC ACTIVITY: PHOSPHOENOLPYRUVATE +
FT                   3-PHOSPHOSHIKIMATE = ORTHOPHOSPHATE +
FT                   O(5)-(1-CARBOXYVINYL)-3-PHOSPHOSHIKIMATE]."
FT                   /EC_number="2.5.1.19"
FT                   /note="Rv3227, (MTCY20B11.02), len: 450 aa. aroA,
FT                   3-phosphoshikimate 1-carboxyvinyl transferase (EC 2.5.1.19)
FT                   (see citation below), equivalent (but C-terminus longer) to
FT                   Q9CCI3|AROA|ML0792 PUTATIVE 3-PHOSPHOSHIKIMATE
FT                   1-CARBOXYVINYL TRANSFERASE from Mycobacterium leprae (430
FT                   aa), FASTA scores: opt: 1466, E(): 1.4e-78, (55.05%
FT                   identity in 427 aa overlap). Contains PS00885 EPSP synthase
FT                   signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY."
FT                   /db_xref="GOA:P22487"
FT                   /db_xref="InterPro:IPR006264"
FT                   /db_xref="PDB:2BJB"
FT                   /db_xref="UniProtKB/Swiss-Prot:P22487"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08328.1"
FT                   /translation="MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGRGAST
FT                   ISGALRSRDTELMLDALQTLGLRVDGVGSELTVSGRIEPGPGARVDCGLAGTVLRFVPP
FT                   LAALGSVPVTFDGDQQARGRPIAPLLDALRELGVAVDGTGLPFRVRGNGSLAGGTVAID
FT                   ASASSQFVSGLLLSAASFTDGLTVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRW
FT                   QVRPGPVAARRWDIEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLN
FT                   AVVIHADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIAHLRGH
FT                   ETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHRMAMAGAIIGLRVAG
FT                   VEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPRSGQRARRATGQGSGG"
FT   misc_feature    136725..136781
FT                   /note="PS00885 EPSP synthase signature 2"
FT   CDS             137063..138055
FT                   /transl_table=11
FT                   /locus_tag="Rv3228"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3228, (MTCY20B11.03), len: 330 aa. Conserved
FT                   hypothetical protein, equivalent to Q9CCI4|ML0791
FT                   HYPOTHETICAL PROTEIN from Mycobacterium leprae (327 aa),
FT                   FASTA scores: opt: 1828, E(): 1e-98, (84.0% identity in 331
FT                   aa overlap). Also similar to several hypothetical bacterial
FT                   proteins e.g. Q9K4A8|SC7E4.08c from Streptomyces coelicolor
FT                   (337 aa), FASTA scores: opt: 1051, E(): 1e-53, (52.65%
FT                   identity in 338 aa overlap); Q9HUL3|PA4952 from Pseudomonas
FT                   aeruginosa (339 aa), FASTA scores: opt: 392 ,E(): 1.4e-15,
FT                   (34.85% identity in 281 aa overlap); Q9PFV1|XF0556 from
FT                   Xylella fastidiosa (341 aa), FASTA scores: opt: 367, E():
FT                   4e-14, (36.85% identity in 247 aa overlap);
FT                   P45339|YJEQ_HAEIN|HI1714 from Haemophilus influenzae (346
FT                   aa), FASTA scores: opt: 355, E(): 2e-13, (31.65% identity
FT                   in 281 aa overlap); etc. Contains PS00017 ATP/GTP-binding
FT                   site motif A."
FT                   /db_xref="GOA:O05873"
FT                   /db_xref="InterPro:IPR010914"
FT                   /db_xref="UniProtKB/TrEMBL:O05873"
FT                   /protein_id="CAB08329.1"
FT                   /translation="MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRW
FT                   GCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRR
FT                   TADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLA
FT                   PAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEAD
FT                   RAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSD
FT                   LAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT"
FT   misc_feature    137672..137695
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   CDS             complement(138088..139371)
FT                   /transl_table=11
FT                   /locus_tag="Rv3229c"
FT                   /standard_name="desA3"
FT                   /product="POSSIBLE LINOLEOYL-CoA DESATURASE
FT                   (DELTA(6)-DESATURASE)"
FT                   /function="THOUGHT TO BE INVOLVED IN LIPID METABOLISM
FT                   [CATALYTIC ACTIVITY: LINOLEOYL-CoA + AH(2) + O(2) =
FT                   GAMMA-LINOLENOYL-CoA + A + 2 H(2)O]"
FT                   /EC_number="1.14.19.3"
FT                   /note="Rv3229c, (MTCY20B11.04c), len: 427 aa. Possible
FT                   linoleoyl-CoA desaturase (EC 1.14.99.25), showing
FT                   similarity with desaturases and other proteins e.g.
FT                   Q08871|DES6|SLL0262 LINOLEOYL-CoA DESATURASE from
FT                   Synechocystis sp. strain PCC 6803 (359 aa), FASTA scores:
FT                   opt: 319, E(): 4e-13, (25.1% identity in 295 aa overlap);
FT                   Q54795|DESD DELTA 6 DESATURASE from Spirulina platensis
FT                   (368 aa), FASTA scores: opt: 268, E(): 7.7e-10, (25.0%
FT                   identity in 300 aa overlap); Q9ZTU8|S276 PROTEIN WITH
FT                   SIMILARITY TO CYTOCHROME B5 DOMAIN from Triticum aestivum
FT                   (Wheat) (469 aa), FASTA scores: opt: 240, E(): 5.9e-08,
FT                   (27.05% identity in 266 aa overlap); etc. Note that
FT                   previously known as desA3."
FT                   /db_xref="GOA:Q7D5W1"
FT                   /db_xref="InterPro:IPR005804"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D5W1"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55572.1"
FT                   /translation="MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRR
FT                   TIAAQRALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWMNDPE
FT                   IHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVTRDQRWKRYNIFNV
FT                   VWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTRLREFSAKAGRQVFKDYVAFPAL
FT                   TSLSPGATYRSTLTANVVANVIRNVWSNAVIFCGHFPDGAEKFTKTDMIGEPKGQWYLR
FT                   QMLGSANFNAGPALRFMSGNLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTG
FT                   SFLVQYGKTWRTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGL
FT                   KTAIAAVRGRRRSKRMAKSVTEPDDLAA"
FT   CDS             complement(139449..140591)
FT                   /transl_table=11
FT                   /locus_tag="Rv3230c"
FT                   /product="HYPOTHETICAL OXIDOREDUCTASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv3230c, (MTCY20B11.05c), len: 380 aa. Putative
FT                   oxidoreductase (EC 1.-.-.-), with some similarity to
FT                   various proteins, especially reductases e.g. Q9HUS4|PA4889
FT                   PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (366
FT                   aa), FASTA scores: opt: 516, E(): 1.8e-24, (33.8% identity
FT                   in 367 aa overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN
FT                   from Pseudomonas putida (337 aa), FASTA scores: opt: 380,
FT                   E(): 4e-16, (30.7% identity in 277 aa overlap);
FT                   BAB34381|ECS0958 NADH OXIDOREDUCTASE FOR THE HCP from
FT                   Escherichia coli strain O157:H7 (322 aa), FASTA scores:
FT                   opt: 369, E(): 1.8e-15, (28.65% identity in 328 aa
FT                   overlap); Q44253|ATDA5 ANILINE DIOXYGENASE REDUCTASE
FT                   COMPONENT from Acinetobacter sp. (336 aa), FASTA scores:
FT                   opt: 305, E(): 1.6e-11, (27.4% identity in 303 aa overlap);
FT                   etc."
FT                   /db_xref="GOA:O05875"
FT                   /db_xref="HSSP:1FRR"
FT                   /db_xref="InterPro:IPR017927"
FT                   /db_xref="UniProtKB/TrEMBL:O05875"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08331.1"
FT                   /translation="MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLP
FT                   DDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDG
FT                   RWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVL
FT                   PDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAA
FT                   DHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDR
FT                   LHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQS
FT                   CVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI"
FT   CDS             complement(140701..141210)
FT                   /transl_table=11
FT                   /locus_tag="Rv3231c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3231c, (MTCY20B11.06c), len: 169 aa. Hypothetical
FT                   protein, similar to Q9KYX9|SCE33.03c HYPOTHETICAL 17.4 KDA
FT                   PROTEIN from Streptomyces coelicolor (167 aa), FASTA
FT                   scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa
FT                   overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O05876"
FT                   /protein_id="CAB08332.1"
FT                   /translation="MTQVYIPATLAMLQRLVADGALWPVNGTAFAVTPTLRESYAEGDD
FT                   EELAEVALREAALASLRLLAADIGATADALPPRRAVLAAEVDDATYRPDLDDAVVRLAG
FT                   PITIDQVVAAYVDNAGAEPAVMAAIAVIDAADLGDEDAELVVGDAQDHDLAWYANQELP
FT                   FLLDLL"
FT   CDS             complement(141207..142094)
FT                   /transl_table=11
FT                   /gene="pvdS"
FT                   /locus_tag="Rv3232c"
FT                   /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN PVDS
FT                   (PROBABLE RNA POLYMERASE SIGMA FACTOR)"
FT                   /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM
FT                   (PROBABLY SIGMA FACTOR PROMOTING ATTACHMENT OF THE RNA
FT                   POLYMERASE TO SPECIFIC INITIATION SITES)."
FT                   /note="Rv3232c, (MTCY20B11.07c), len: 295 aa (start
FT                   uncertain). Possible pvdS, an alternative RNA polymerase
FT                   sigma factor, highly similar (but N-terminus longer 25-50
FT                   residues approximatively) to Q9RIZ9|SCJ1.15 PUTATIVE
FT                   REGULATOR from Streptomyces coelicolor (267 aa), FASTA
FT                   scores: opt: 1189, E(): 1.4e-70, (65.65% identity in 262 aa
FT                   overlap); Q9KU02|VC0728 HYPOTHETICAL PROTEIN from Vibrio
FT                   cholerae (258 aa), FASTA scores: opt: 1074, E(): 4.5e-63,
FT                   (62.6% identity in 254 aa overlap); P72119|PVDS PAO
FT                   SUBSTRAIN OT684 PYOVERDINE GENE TRANSCRIPTIONAL REGULATOR
FT                   PVDS (FRAGMENT) from Pseudomonas aeruginosa (see citations
FT                   below) (237 aa), FASTA scores: opt: 988, E(): 1.8e-57,
FT                   (60.8% identity in 227 aa overlap). Also highly similar to
FT                   Q9I154|PA2428 HYPOTHETICAL PROTEIN from Pseudomonas
FT                   aeruginosa (304 aa), FASTA scores: opt: 1057, E(): 6.8e-62,
FT                   (60.7% identity in 252 aa overlap); Q9I6Z1|PA0141
FT                   HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (298 aa),
FT                   FASTA scores: opt: 990, E(): 1.6e-57, (54.6% identity in
FT                   249 aa overlap); and other hypothetical bacterial proteins.
FT                   Could be a member of a subfamily of RNA polymerase sigma
FT                   factors which direct the synthesis of extracellular
FT                   products by bacteria."
FT                   /db_xref="InterPro:IPR005660"
FT                   /db_xref="UniProtKB/TrEMBL:O05877"
FT                   /protein_id="CAB08333.1"
FT                   /translation="MDIPSVDVSTATNDGASSRAKGHRSAAPGRRKISDAVYQAELFRL
FT                   QTEFVKLQEWARHSGARLVVIFEGRDGAGKGGAIKRITEYLNPRVARIAALPAPTDRER
FT                   GQWYYQRYIAHLPAKGEIVLFDRSWYNRAGVEKVMGFCTPQEYVLFLRQTPIFEQMLID
FT                   DGILLRKYWFSVSDAEQLRRFKARRNDPVRQWKLSPMDLESVYRWEDYSRAKDEMMVHT
FT                   DTPVSPWYVVESDIKKHARLNMMAHLLSTIDYADVEKPKVKLPPRPLVSGNYRRPPREL
FT                   STYVDDYVATLIAR"
FT   CDS             complement(142118..142708)
FT                   /transl_table=11
FT                   /locus_tag="Rv3233c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3233c, (MTCY20B11.08c), len: 196 aa. Hypothetical
FT                   protein, similar to C-terminus of Q9RIU8|SCM11.13c
FT                   HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor
FT                   (446 aa), FASTA scores: opt: 308, E(): 1.2e-12, (32.0%
FT                   identity in 200 aa overlap); and several hypothetical M.
FT                   tuberculosis proteins e.g.
FT                   O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497 aa), FASTA
FT                   scores: opt: 248, E(): 9.8e-09, (27.5% identity in 200 aa
FT                   overlap); MTCY28_26; MTCY493_29; MTCY31_25; MTCY31_25."
FT                   /db_xref="UniProtKB/TrEMBL:O05878"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08334.1"
FT                   /translation="MIAGALGNWLMSRGEAVAPTATVRAMAPLSVYADDQLDSTGPGQA
FT                   ISQVTPFLVDLPVGEGNAVVRLSQIAHATESNPTAASLVDARTIVTLSGLAPATLHAMG
FT                   VRVATSFSARLFNLLITNAPGTQSQMYIAGTKLLETYSVPPLLHNQALAISVTSYNGML
FT                   YFGINADRDAMSDVDLLPGLLSQALDELLEASR"
FT   CDS             complement(142711..143526)
FT                   /transl_table=11
FT                   /locus_tag="Rv3234c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3234c, (MTCY20B11.09c), len: 271 aa. Hypothetical
FT                   protein, similar to C-terminus of Mycobacterium
FT                   tuberculosis hypothetical proteins e.g.
FT                   P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa), FASTA
FT                   scores: opt: 498, E(): 5.2e-24, (36.8% identity in 261 aa
FT                   overlap); MTCY03A2.28; MTCY31.23; MTCY493_29; MTCY28_26;
FT                   MTV013_8; MTY13E12_33; etc. Also similar to
FT                   Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from
FT                   Mycobacterium leprae (491 aa), FASTA scores: opt: 309, E():
FT                   4.3e-12, (33.35% identity in 189 aa overlap)."
FT                   /db_xref="InterPro:IPR004255"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05879"
FT                   /protein_id="CAB08335.1"
FT                   /translation="MVTRLSASDASFYQLENTATPMYVGLLLILRRPRAGLSYEALLET
FT                   VEQRLPQIPRYRQKVQEVKLGLARPVWIDDRDFDITYHVRRSALPSPGSDEQLHELIAR
FT                   LAARPLDKSRPLWEMYLVEGLEKNRIALYTKSHQALINGVTALAIGHVIADRTRRPPAF
FT                   PEDIWVPERDPGTTRLLLRAVGDWLVRPGAQLQAVGSAVAGLVTNSGQLVETGRKVLDI
FT                   ARTVARGTAPSSPLNATVSRNRRFTVARASLDDYRTVRARYDCDSTTWC"
FT   CDS             143637..144278
FT                   /transl_table=11
FT                   /locus_tag="Rv3235"
FT                   /product="HYPOTHETICAL ALANINE ARGININE PROLINE RICH
FT                   PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3235, (MTCY20B11.10), len: 213 aa. Hypothetical
FT                   unknown ala-, arg-, pro-rich protein."
FT                   /db_xref="UniProtKB/TrEMBL:O05880"
FT                   /protein_id="CAB08336.1"
FT                   /translation="MMASNQTAAQHSSATLQQAPRSIDDAGGCPLTISPIANSPGDTFA
FT                   VTPVVEYEPPPRNIPPCGQSSHAARRPHTPQLARRQPIRPSGRAPAAVTSTAKSPRLRQ
FT                   AGTFADAALRRVLEVIDRRRPVGQLRPLLAPGLVDSVLAVSRTAAGHQQGAAMLRRIRL
FT                   TPAGPDTADTAAEVFGTYSRGDRIHAIACRVEQRPAGNETRWLMVALHIG"
FT   CDS             complement(144296..145453)
FT                   /transl_table=11
FT                   /locus_tag="Rv3236c"
FT                   /standard_name="kefB"
FT                   /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT
FT                   PROTEIN"
FT                   /function="PROBABLY INVOLVED IN TRANSPORT OF UNDETERMINATED
FT                   SUBSTRATE (POSSIBLY CATIONS Na/H) ACROSS THE MEMBRANE.
FT                   THOUGHT TO BE RESPONSIBLE FOR THE TRANSLOCATION OF THE
FT                   SUBSTRATE ACROSS THE MEMBRANE."
FT                   /note="Rv3236c, (MTCY20B11.11c), len: 385 aa. Probable
FT                   conserved integral membrane transport protein, possibly
FT                   cation (Na/H) transporter, equivalent to Q9CCI5|ML0782
FT                   putative transmembrane transport protein from Mycobacterium
FT                   leprae (385 aa), FASTA scores: opt: 1975, E(): 2.4e-108,
FT                   (81.55% identity in 385 aa overlap). Highly similar to
FT                   others e.g. O69958|SC4H2.03c putative transmembrane
FT                   transport protein from Streptomyces coelicolor (411 aa),
FT                   FASTA scores: opt: 1226, E(): 1.6e-64, (53.5% identity in
FT                   372 aa overlap); Q9XAKO|SC66T3.13c putative transmembrane
FT                   transport protein from Streptomyces coelicolor (403 aa),
FT                   FASTA scores: opt: 1198, E(): 6.8e-63, (53.25% identity in
FT                   370 aa overlap); Q9RV80|DR1149 putative Na+/H+ antiporter
FT                   from Deinococcus radiodurans (383 aa), FASTA scores: opt:
FT                   1069, E(): 2.3e-55, (47.35% identity in 376 aa overlap);
FT                   Q9L191|SC10G8.11 putative transmembrane transport protein
FT                   from Streptomyces coelicolor (446 aa), FASTA scores: opt:
FT                   695, E(): 1.9e-33, (38.05% identity in 384 aa overlap);
FT                   Q9RRW8|DR2367 putative glutathione-regulated
FT                   potassium-efflux system protein KEFB from Deinococcus
FT                   radiodurans (575 aa), FASTA scores: opt: 414, E(): 6.2e-17,
FT                   (30.25% identity in 380 aa overlap); etc. SEEMS TO BELONG
FT                   TO THE CPA2 FAMILY. Note that previously known as kefB."
FT                   /db_xref="GOA:Q7D5V5"
FT                   /db_xref="InterPro:IPR006153"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D5V5"
FT                   /protein_id="CAE55573.1"
FT                   /translation="MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLGN
FT                   GGILGVAAAGEFIATGAPIGVVLLLLALGLEFSATEFASSLRHHLPSAGVDIVLNATPG
FT                   AVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMA
FT                   AYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVTHPDSEQLLLRV
FT                   LGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRARMVLTPLRDLFATIFFLGIGLS
FT                   VDPGKLVSMLPVALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARGEFSLII
FT                   IGLAGASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN"
FT   CDS             complement(145458..145940)
FT                   /transl_table=11
FT                   /locus_tag="Rv3237c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3237c, (MTCY20B11.12c), len: 160 aa. Conserved
FT                   hypothetical protein, equivalent to Q9CCI6|ML0781
FT                   HYPOTHETICAL PROTEIN from Mycobacterium leprae (160 aa),
FT                   FASTA scores: opt: 828, E(): 1.5e-45, (80.6% identity in
FT                   160 aa overlap); and similar to other hypothetical
FT                   bacterial proteins and more weakly to putative potassium
FT                   channels e.g. Q9RV81|DR1148 CONSERVED HYPOTHETICAL PROTEIN
FT                   from Deinococcus radiodurans (175 aa), FASTA scores: opt:
FT                   420, E(): 9.5e-20, (37.95% identity in 158 aa overlap);
FT                   O69959|SC4H2.04c HYPOTHETICAL 17.1 KDA PROTEIN from
FT                   Streptomyces coelicolor (161 aa), FASTA scores: opt: 315,
FT                   E(): 3.8e-13, (40.0% identity in 150 aa overlap);
FT                   Q9HNH3|PCHB|VNG2104G POTASSIUM CHANNEL HOMOLOG from
FT                   Halobacterium sp. strain NRC-1 (418 aa), FASTA scores: opt:
FT                   158, E(): 0.007, (31.45% identity in 124 aa overlap);
FT                   Q58752|YD57_METJA|MJ1357 PUTATIVE POTASSIUM CHANNEL PROTEIN
FT                   from Methanococcus jannaschii (343 aa), FASTA scores: opt:
FT                   143, E(): 0.053, (33.8% identity in 68 aa overlap)."
FT                   /db_xref="GOA:O05882"
FT                   /db_xref="InterPro:IPR006037"
FT                   /db_xref="UniProtKB/TrEMBL:O05882"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08338.1"
FT                   /translation="MDVKEVLLPGVGLRYEFTSYRGDRIGIVARRSGGFDVVLYGRDDP
FT                   DEARPVLRLTDEEAEAVAQILGAPRIAERFTELTREVPGLKAGQIHIRAGSLFVDRPLG
FT                   DTRARTRTGASIVAIVRDEDVLASPGPTDVLRAGDVLIVIGTEDGIAGVEQIVEKG"
FT   CDS             complement(146001..146735)
FT                   /transl_table=11
FT                   /locus_tag="Rv3238c"
FT                   /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3238c, (MTCY20B11.13c), len: 244 aa. Probable
FT                   conserved integral membrane protein, similar to several
FT                   hypothetical proteins and transmembrane proteins e.g.
FT                   Q9UN92|NRM29 MULTISPANNING NUCLEAR ENVELOPE MEMBRANE
FT                   PROTEIN NURIM (FRAGMENT) from Homo sapiens (Human) (261
FT                   aa), FASTA scores: opt: 281, E(): 3.3e-11, (30.7% identity
FT                   in 189 aa overlap); Q9VEG9|CG7655 HYPOTHETICAL PROTEIN from
FT                   Drosophila melanogaster (Fruit fly) (253 aa), FASTA scores:
FT                   opt: 242, E(): 1.1e-08, (27.7% identity in 242 aa overlap);
FT                   BAB48937|MLR1600 HYPOTHETICAL PROTEIN from Rhizobium loti
FT                   (Mesorhizobium loti) (222 aa), FASTA scores: opt: 137, E():
FT                   0.066, (28.1% identity in 185 aa overlap); BAB57936|SAV1774
FT                   AESENICAL PUMP MEMBRANE PROTEIN HOMOLOG from Staphylococcus
FT                   aureus subsp. aureus Mu50 (430 aa), FASTA scores: opt: 125,
FT                   E(): 0.68, (25.7% identity in 144 aa overlap); etc."
FT                   /db_xref="UniProtKB/TrEMBL:O05883"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08339.1"
FT                   /translation="MKRYLTIIYGAASYLVFLVAFGYAIGFVGDVVVPRTVDHAIAAPI
FT                   GQAVVVNLVLLGVFAVQHSVMARQGFKRWWTRFVPPSIERSTYVLLASVALLLLYWQWR
FT                   TMPAVIWDVRQPAGRVALWALFWLGWATVLTSTFMINHFELFGLRQVYLAWRGKPYTEI
FT                   GFQAHLLYRWVRHPIMLGFVVAFWATPMMTAGHLLFAIGATGYILVALQFEERDLLAAL
FT                   GDQYRDYRREVSMLLPWPHRHT"
FT   CDS             complement(146794..149940)
FT                   /transl_table=11
FT                   /locus_tag="Rv3239c"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT
FT                   PROTEIN"
FT                   /function="UNKNOWN, BUT SEEMS INVOLVED IN EFFLUX SYSTEM
FT                   (PROBABLY SUGAR OR DRUG TRANSPORT)."
FT                   /note="Rv3239c, (MTCY20B11.14c), len: 1048 aa. Probable
FT                   conserved transmembrane protein, organised in two domains.
FT                   Domain comprising first ~500 aa residues is similar to
FT                   various antibiotic resistance and efflux proteins and
FT                   contains sugar transport proteins signature 1 (PS00216);
FT                   e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN
FT                   from Streptomyces coelicolor (489 aa), FASTA scores: opt:
FT                   905, E(): 3.1e-41, (36.95% identity in 482 aa overlap); and
FT                   O68912|FRNF PUTATIVE ANTIBIOTIC ANTIPORTER from
FT                   Streptomyces roseofulvus (517 aa), FASTA scores: opt: 866,
FT                   E(): 4.1e-39, (37.1% identity in 512 aa overlap). Second
FT                   part, corresponding to last 550 aa residues, is very
FT                   similar to Q50733|Rv2565|MTCY9C4.03c hypothetical 62.1 kDa
FT                   protein from Mycobacterium tuberculosis (583 aa), FASTA
FT                   scores: E(): 2.1e-28, (36.5% identity in 572 aa overlap).
FT                   Also equivalent to Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN
FT                   MEMBRANE PROTEIN (SIMILAR TO SUGAR TRANSPORTER FAMILY) from
FT                   Mycobacterium tuberculosis (1065 aa), FASTA scores: opt:
FT                   4328, E(): 0, (64.15% identity in 1046 aa overlap); and
FT                   similar to other Mycobacterium tuberculosis proteins:
FT                   MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E(): 6.3e-32;
FT                   MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E(): 2.5e-26.
FT                   Equivalent to AAK47679 Drug transporter from Mycobacterium
FT                   tuberculosis strain CDC1551 (1065 aa) but shorter 20 aa.
FT                   Contains cyclic nucleotide-binding domain signature 2
FT                   (PS00889). Probably member of major facilitator superfamily
FT                   (MFS)."
FT                   /db_xref="GOA:O05884"
FT                   /db_xref="InterPro:IPR014710"
FT                   /db_xref="UniProtKB/TrEMBL:O05884"
FT                   /protein_id="CAB08340.1"
FT                   /translation="MHISLHGGKGFANLTRRRRPSSASVLLVAGFGAFLAFLDSTIVNI
FT                   AFPDIQRSFPSYDIGSLSWILNGYNIVFAAFMVAAGRLADLLGRRRTFLSGVLVFTIAS
FT                   GLCAVAGSVEQLVAFRVLQGIGAAILVPASLALVVEGFDAARRAHAIGLWGAAAAIAAG
FT                   LGPPIGGLLVEWAGWRWVLLVNVPLGIVAAIATKRMLVESRASGRRRMPDLRGALLLAV
FT                   TLGLVTLGLVKGPDWGWLSVATVGSFLASVLTSVGFVHSSRSHPAPLVEPALLRSRSFV
FT                   AGNLLTLVAAAGFYCYGLTHVLYLNYVWHYSLLKAGFAIAPAAVVAAVVAAALGRVAGR
FT                   HGHRVIVLVGALVWAGSLVWYLQRVGSEPDFLRVWLPGQLLQGIGVGATLPVLSSAALA
FT                   EVAKGGSYATSSAVVSTTRQLGAVLGVAVMVILIGKPEHGTAEEALRRGWAMAAICFIA
FT                   VAVAAAVLGRTNRNPVQMPAPEPAIAPRLEPPIPQPAAAPIEHWAAGDADPLGNLPLFA
FT                   GLDAATLAQLGEHVEDVELEAGCYLFHEGDPSDSLYVIRTGRVQVLQDSIVLKELGRGE
FT                   VLGELGLLIDAPRSATVRALRDTKLVRLTKAQFDEIADHGALAALVKVLATRLREAPPP
FT                   ATDSTSPEVVVSVIGVSGDAPVPAVAAGLLTALSARLRAVDPGRVDRDGLDRAERVADK
FT                   VVLHAAVEDAGWRDFCLRVADRIVLVAGDPNPQAARLPARARGADLVLAGPAASREHRR
FT                   QWEELITPRSVHVVHYRRILENVRPLAARIAGRSIGLVLGGGGARGFAHLGVLDELERV
FT                   GVTIDRFAGTSMGAVIAVFGACGMDAATADAYAYEYFIRHNPLSDYAFPVRGLVRGRRT
FT                   LTLLEAAFGDRLVEELPKEFRCVSVDLLARRPVVHRRGRLVDVIGCSLRLPGIYPPQVY
FT                   NGRLHVDGGVLDNLPVSTRASPDGPLIAVSIGLGGGGPGSARQDGSPKVPGIGDTLMRT
FT                   MTIGSQRGADAALSLAQVVIRPDTGAVGLLEFHQIDAAREAGRVAAREAMPHIMALLNR
FT                   "
FT   misc_feature    complement(148156..148209)
FT                   /note="PS00889 Cyclic nucleotide-binding domain signature
FT                   2"
FT   misc_feature    complement(149653..149703)
FT                   /note="PS00216 Sugar transport proteins signature 1"
FT   CDS             complement(150019..152868)
FT                   /transl_table=11
FT                   /gene="secA1"
FT                   /locus_tag="Rv3240c"
FT                   /standard_name="secA"
FT                   /product="PROBABLE PREPROTEIN TRANSLOCASE SECA1 1 SUBUNIT"
FT                   /function="INVOLVED IN PROTEIN EXPORT. INTERACTS WITH THE
FT                   SECY/SECE SUBUNITS. SECA HAS A CENTRAL ROLE IN COUPLING THE
FT                   HYDROLYSIS OF ATP TO THE TRANSFER OF PRE-SECRETORY
FT                   PERIPLASMIC AND OUTER MEMBRANE PROTEINS ACROSS THE
FT                   MEMBRANE."
FT                   /note="Rv3240c, (MTCY20B11.15c), len: 949 aa. Probable
FT                   secA1, preprotein translocase subunit, component of
FT                   secretion apparatus (see citations below), highly similar
FT                   to many e.g. P57996|SEA1_MYCLE from Mycobacterium leprae
FT                   (940 aa), FASTA scores: opt: 5044, E(): 0, (87.5% identity
FT                   in 849 aa overlap); P95759|SECA_STRGR from Streptomyces
FT                   griseus (940 aa), FASTA scores: opt: 2612, E(): 1.9e-134,
FT                   (61.35% identity in 960 aa overlap); P28366|SECA_BACSU|DIV+
FT                   from Bacillus subtilis (841 aa), FASTA scores: opt: 1776,
FT                   E(): 4.9e-89, (48.05% identity in 837 aa overlap); etc.
FT                   BELONGS TO THE SECA FAMILY. PART OF THE PROKARYOTIC PROTEIN
FT                   TRANSLOCATION APPARATUS WHICH COMPRISE SECA, SECD|Rv2587c,
FT                   SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732.
FT                   Note that previously known as secA."
FT                   /db_xref="GOA:P0A5Y8"
FT                   /db_xref="InterPro:IPR000185"
FT                   /db_xref="PDB:1NL3"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5Y8"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55574.1"
FT                   /translation="MLSKLLRLGEGRMVKRLKKVADYVGTLSDDVEKLTDAELRAKTDE
FT                   FKRRLADQKNPETLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGAAALHLGNVAEMKTG
FT                   EGKTLTCVLPAYLNALAGNGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILATMTPD
FT                   ERRVAYNADITYGTNNEFGFDYLRDNMAHSLDDLVQRGHHYAIVDEVDSILIDEARTPL
FT                   IISGPADGASNWYTEFARLAPLMEKDVHYEVDLRKRTVGVHEKGVEFVEDQLGIDNLYE
FT                   AANSPLVSYLNNALKAKELFSRDKDYIVRDGEVLIVDEFTGRVLIGRRYNEGMHQAIEA
FT                   KEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVSIPTNMPM
FT                   IREDQSDLIYKTEEAKYIAVVDDVAERYAKGQPVLIGTTSVERSEYLSRQFTKRRIPHN
FT                   VLNAKYHEQEATIIAVAGRRGGVTVATNMAGRGTDIVLGGNVDFLTDQRLRERGLDPVE
FT                   TPEEYEAAWHSELPIVKEEASKEAKEVIEAGGLYVLGTERHESRRIDNQLRGRSGRQGD
FT                   PGESRFYLSLGDELMRRFNGAALETLLTRLNLPDDVPIEAKMVTRAIKSAQTQVEQQNF
FT                   EVRKNVLKYDEVMNQQRKVIYAERRRILEGENLKDQALDMVRDVITAYVDGATGEGYAE
FT                   DWDLDALWTALKTLYPVGITADSLTRKDHEFERDDLTREELLEALLKDAERAYAAREAE
FT                   LEEIAGEGAMRQLERNVLLNVIDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGY
FT                   DMFMAMLDGMKEESVGFLFNVTVEAVPAPPVAPAAEPAELAEFAAAAAAAAQQRSAVDG
FT                   GARERAPSALRAKGVASESPALTYSGPAEDGSAQVQRNGGGAHKTPAGVPAGASRRERR
FT                   EAARRQGRGAKPPKSVKKR"
FT   CDS             complement(152947..153591)
FT                   /transl_table=11
FT                   /locus_tag="Rv3241c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN, BUT MAY BE INVOLVED IN TRANSDUCTION
FT                   MECHANISM"
FT                   /note="Rv3241c, (MTCY20B11.16c), len: 213 aa. Conserved
FT                   hypothetical protein, similar to many hypothetical proteins
FT                   and to some putative ribosomal proteins e.g. Q9CCI7|ML0778
FT                   HYPOTHETICAL PROTEIN from Mycobacterium leprae (229 aa),
FT                   FASTA scores: opt: 1234, E(): 1.3e-72, (89.3% identity in
FT                   206 aa overlap); Q9KYX2|SCE33.11c HYPOTHETICAL 27.9 KDA
FT                   PROTEIN from Streptomyces coelicolor (254 aa), FASTA
FT                   scores: opt: 487, E(): 2.2e-24, (47.6% identity in 210 aa
FT                   overlap); Q9FLV3 PROTEIN SIMILAR TO RIBOSOMAL PROTEIN 30S
FT                   SUBUNIT from Arabidopsis thaliana (Mouse-ear cress) (365
FT                   aa), FASTA scores: opt: 264, E(): 7e-10, (26.4% identity in
FT                   212 aa overlap); P19954|RR30_SPIOL|RPS22 PLASTID-SPECIFIC
FT                   30S RIBOSOMAL PROTEIN 1, chloroplast, from Spinacia
FT                   oleracea (Spinach) (302 aa), FASTA scores: opt: 261, E():
FT                   9.3e-10, (26.15% identity in 214 aa overlap);
FT                   P47995|YSEA_STACA HYPOTHETICAL PROTEIN IN SECA 5'REGION
FT                   (ORF1) (FRAGMENT) (BELONGS TO THE S30AE FAMILY OF RIBOSOMAL
FT                   PROTEINS) from Staphylococcus carnosus (165 aa), FASTA
FT                   scores: opt: 201, E(): 4.2e-06, (33.35% identity in 147 aa
FT                   overlap); etc."
FT                   /db_xref="GOA:O05886"
FT                   /db_xref="InterPro:IPR003489"
FT                   /db_xref="UniProtKB/TrEMBL:O05886"
FT                   /protein_id="CAB08342.1"
FT                   /translation="MDSGQVLAEPKSNAEIVFKGRNVEIPDHFRIYVSQKLARLERFDR
FT                   TIYLFDVELDHERNRRQRKSCQRVEITARGRGPVVRGEACADSFYAALESAVVKLESRL
FT                   RRGKDRRKVHYGDKTPVSLAEATAVVPAPENGFNTRPAEAHDHDGAVVEREPGRIVRTK
FT                   EHPAKPMSVDDALYQMELVGHDFFLFYDKDTERPSVVYRRHAYDYGLIRLA"
FT   CDS             complement(153907..154548)
FT                   /transl_table=11
FT                   /locus_tag="Rv3242c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3242c, (MTCY20B11.17c), len: 213 aa. Conserved
FT                   hypothetical protein, highly similar in N-terminus to
FT                   Q9CCI9|ML0776 HYPOTHETICAL PROTEIN from Mycobacterium
FT                   leprae (85 aa), FASTA scores: opt: 324, E(): 1.7e-13,
FT                   (78.1% identity in 64 aa overlap). Also similar to
FT                   Q9RUJ7|DR1389 PUTATIVE COMPETENCE PROTEIN COMF from
FT                   Deinococcus radiodurans (219 aa), FASTA scores: opt: 223,
FT                   E(): 6.3e-07, (35.8% identity in 215 aa overlap);
FT                   BAB50338|MLL3453 HYPOTHETICAL PROTEIN from Rhizobium loti
FT                   (Mesorhizobium loti) (240 aa), FASTA scores: opt: 218, E():
FT                   1.4e-06, (28.5% identity in 224 aa overlap); Q9A9Y1|CC0830
FT                   COMPETENCE PROTEIN F from Caulobacter crescentus (265 aa),
FT                   FASTA scores: opt: 182, E(): 0.00026, (30.15% identity in
FT                   219 aa overlap); etc. Equivalent to AAK47682 from
FT                   Mycobacterium tuberculosis strain CDC1551 (241 aa) but
FT                   shorter 29 aa. Contains purine/pyrimidine phosphoribosyl
FT                   transferases signature (PS00103). SEEMS TO BELONG TO
FT                   PURINE/PYRIMIDINE PHOSPHORIBOSYL TRANSFERASE FAMILY."
FT                   /db_xref="GOA:O05887"
FT                   /db_xref="HSSP:1LH0"
FT                   /db_xref="InterPro:IPR002375"
FT                   /db_xref="UniProtKB/TrEMBL:O05887"
FT                   /protein_id="CAB08343.1"
FT                   /translation="MLDLVLPLECGGCGAPATRWCAACAAELSVAAGEPHVVSPRVDPQ
FT                   VPVFALGRYAGVRRQAILAMKEHGRRDLVAPLACALIVGVDHLLSWGMLENPLTMVPAP
FT                   TRRWAARRRGGDPVSRMARIAGATLGRHHDVTVVPALRMRALARDSVGLGASARERNIT
FT                   GRVLLRGQRPRNEVVLVDDIITTGATARESVRVLQAAGVRVGAVLAVAAA"
FT   misc_feature    complement(153982..154020)
FT                   /note="PS00103 Purine/pyrimidine phosphoribosyl
FT                   transferases signature"
FT   CDS             complement(154586..155428)
FT                   /transl_table=11
FT                   /locus_tag="Rv3243c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3243c, (MTCY20B11.18c), len: 280 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O05888"
FT                   /protein_id="CAB08344.1"
FT                   /translation="MSPRVPRLRWDDPFRALDMLASLWSSTGMSLVSAGAAQAVAAPYR
FT                   TLFTTLQQLLIGKEVTVRIGDHDVVLTVTELDSALEPQGLAVGQLGEVRVAARGISWDQ
FT                   HHLHSAVAVLRNVHIRPGVPPLVIAAPVELSSALPTEIFDDVLRQATPQLRGELSESGA
FT                   ARLRWARRPDWGGLEVDVDVAGTTSQTTLWLRPRTVITGQRRWTLPARTPAYRVPLPEL
FT                   PHGLRITDVSLAADCLQLSALLPEWRTELPLRYLESVITQLSQGALSFVWPPLRSGAD"
FT   CDS             complement(155496..157247)
FT                   /transl_table=11
FT                   /gene="lpqB"
FT                   /locus_tag="Rv3244c"
FT                   /product="PROBABLE CONSERVED LIPOPROTEIN LPQB"
FT                   /function="UNKNOWN"
FT                   /note="Rv3244c, (MTCY20B11.19c), len: 583 aa. Probable
FT                   lpqB, conserved lipoprotein; contains appropriately placed
FT                   lipoprotein signature (PS00013). Equivalent to
FT                   Q9CCJ0|LPQB|ML0775 PUTATIVE LIPOPROTEIN from Mycobacterium
FT                   leprae (589 aa), FASTA scores: opt: 3375, E(): 1.4e-186,
FT                   (87.9% identity in 579 aa overlap). Also similar to various
FT                   proteins (in particular transferases) e.g. Q9KYX0|SCE33.13c
FT                   PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (615 aa),
FT                   FASTA scores: opt: 228, E(): 1.3e-05, (25.5% identity in
FT                   624 aa overlap); O87992|BBLPS1.19c PUTATIVE GLUTAMINE
FT                   AMIDOTRANSFERASE from Bordetella bronchiseptica
FT                   (Alcaligenes bronchisepticus) (628 aa), FASTA scores: opt:
FT                   162, E(): 0.079, (28.05% identity in 171 aa overlap);
FT                   Q9L2F4|SC7A8.01 PUTATIVE SUGAR KINASE (FRAGMENT) from
FT                   Streptomyces coelicolor (434 aa), FASTA scores: opt: 143,
FT                   E(): 0.72, (27.65% identity in 293 aa overlap); etc."
FT                   /db_xref="GOA:O05889"
FT                   /db_xref="InterPro:IPR019606"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05889"
FT                   /protein_id="CAB08345.1"
FT                   /translation="MRLTILLFLGAVLAGCASVPSTSAPQAIGTVERPVPSNLPKPSPG
FT                   MDPDVLLREFLKATADPANRHLAARQFLTESASNAWDDAGSALLIDHVVFVETRSAEKV
FT                   SVTMRADILGSLSDVGVFETAEGQLPDPGPIELVKTSDGWRIDRLPNGVFLDWQQFQET
FT                   YKRNTLYFADPTGKTVVPDPRYVAVSDRDQLATELVSKLLAGPRPEMARTVRNLLAPPL
FT                   RLRGPVTRADGGKSGIGRGYGGARVDMEKLSTTDPHSRQLLAAQIIWTLARADIRGPYV
FT                   INADGAPLEDRFAEGWTTSDVAATDPGVADGAAAGLHALVNGSLVAMDAQRVTPVPGAF
FT                   GRMPEQTAAAVSRSGRQVASVVTLGRGAPDEAASLWVGDLGGEAVQSADGHSLSRPSWS
FT                   LDDAVWVVVDTNVVLRAIQDPASGQPARIPVDSTAVASRFPGAINDLQLSRDGTRAAMV
FT                   IGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDAAHPVSYV
FT                   NLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGWADVPGLMVPG
FT                   AAPVLPG"
FT   misc_feature    complement(157200..157232)
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             complement(157247..158950)
FT                   /transl_table=11
FT                   /gene="mtrB"
FT                   /locus_tag="Rv3245c"
FT                   /product="TWO COMPONENT SENSORY TRANSDUCTION HISTIDINE
FT                   KINASE MTRB"
FT                   /function="SENSOR PART OF A TWO COMPONENT REGULATORY
FT                   SYSTEM."
FT                   /EC_number="2.7.3.-"
FT                   /note="Rv3245c, (MTCY20B11.20c), len: 567 aa. mtrB,
FT                   sensor-like histidine kinase (EC 2.7.3.-) (see citations
FT                   below), equivalent to Q9CCJ1|MTRB OR ML0774 PUTATIVE
FT                   TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium
FT                   leprae (562 aa), FASTA scores: opt: 3208, E(): 7.4e-173,
FT                   (88.7% identity in 566 aa overlap). Also similar to others
FT                   e.g. Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM
FT                   HISTIDINE KINASE from Streptomyces coelicolor (688 aa),
FT                   FASTA scores: opt: 1355, E(): 1.1e-68, (48.95% identity in
FT                   515 aa overlap); etc. Relatives in Mycobacterium
FT                   tuberculosis are: MTCY369.03, E(): 1.5e-22; MTCY20G9.16,
FT                   E(): 1.9e-17. SIMILAR TO OTHER PROKARYOTIC SENSORY
FT                   TRANSDUCTION HISTIDINE KINASES."
FT                   /db_xref="GOA:Q50496"
FT                   /db_xref="InterPro:IPR005467"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q50496"
FT                   /protein_id="CAB08346.1"
FT                   /translation="MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVAL
FT                   TLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSL
FT                   QLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKAGQA
FT                   AYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVL
FT                   LVLLAGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAES
FT                   LSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSADLDPTLRRSTELMV
FT                   SELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDL
FT                   PAEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPG
FT                   EEKLVFSRFWRSDPSRVRRSGGTGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPM
FT                   VRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPREHAEWSG"
FT   repeat_region   complement(158951..159003)
FT                   /note="53 bp Mycobacterial Interspersed Repetitive Unit,
FT                   Class II"
FT   CDS             complement(159000..159686)
FT                   /transl_table=11
FT                   /gene="mtrA"
FT                   /locus_tag="Rv3246c"
FT                   /product="TWO COMPONENT SENSORY TRANSDUCTION
FT                   TRANSCRIPTIONAL REGULATORY PROTEIN MTRA"
FT                   /function="TRANSCRIPTIONAL ACTIVATOR PART OF A TWO
FT                   COMPONENT REGULATORY SYSTEM."
FT                   /note="Rv3246c, (MTCY20B11.21c), len: 228 aa. mtrA,
FT                   transcriptional activator, response regulator (see
FT                   citations below), equivalent to Q9CCJ2|MTRA|ML0773 PUTATIVE
FT                   TWO-COMPONENT RESPONSE REGULATOR from Mycobacterium leprae
FT                   (228 aa), FASTA scores: opt: 1458, E(): 1.4e-85, (98.7%
FT                   identity in 228 aa overlap). Also highly similar to others
FT                   e.g. Q9F9J5|SCRA PUTATIVE RESPONSE REGULATOR from
FT                   Streptomyces coelicolor (228 aa), FASTA scores: opt: 1141,
FT                   E(): 1.9e-65, (74.9% identity in 227 aa overlap);
FT                   Q9KYW8|SCE33.15c PUTATIVE TWO-COMPONENT SYSTEM RESPONSE
FT                   REGULATOR from Streptomyces coelicolor (229 aa), FASTA
FT                   scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa
FT                   overlap); Q9F868|REGX3 RESPONSE REGULATOR REGX3 from
FT                   Mycobacterium smegmatis (228 aa), FASTA scores: opt: 730,
FT                   E(): 2.3e-39, (50.90% identity in 222 aa overlap); etc.
FT                   Relatives in Mycobacterium tuberculosis are:
FT                   U01971|MTU01971_1; Q11156|RGX3_MYCTU; MTCY20G9.17, E(): 0;
FT                   MTCY31.31c, E(): 3.4e-29; MTCY369.02, E(): 5.7e-28. SIMILAR
FT                   TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL
FT                   TRANSDUCTION. THE N-TERMINAL REGION IS SIMILAR TO THAT OF
FT                   OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION
FT                   SYSTEMS. Experiments showed mtrA is differentially
FT                   expressed in virulent and avirulent strains during growth
FT                   in macrophages."
FT                   /db_xref="GOA:P0A5Z4"
FT                   /db_xref="InterPro:IPR001867"
FT                   /db_xref="PDB:2GWR"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5Z4"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08347.1"
FT                   /translation="MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAV
FT                   RELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIM
FT                   KPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLV
FT                   ALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG
FT                   YKAGPP"
FT   CDS             complement(159756..160400)
FT                   /transl_table=11
FT                   /gene="tmk"
FT                   /locus_tag="Rv3247c"
FT                   /product="PROBABLE THYMIDYLATE KINASE TMK (dTMP KINASE)
FT                   (THYMIDYLIC ACID KINASE) (TMPK)"
FT                   /function="PHOSPHORYLATION OF DTMP TO FORM DTDP IN BOTH DE
FT                   NOVO AND SALVAGE PATHWAYS OF DTTP SYNTHESIS [CATALYTIC
FT                   ACTIVITY: ATP + THYMIDINE 5'-PHOSPHATE = ADP + THYMIDINE
FT                   5'-DIPHOSPHATE]."
FT                   /EC_number="2.7.4.9"
FT                   /note="Rv3247c, (MTCY20B11.22c), len: 214 aa. Probable tmk,
FT                   thymidylate kinase (EC 2.7.4.9), equivalent to
FT                   Q9CCJ3|TMK|ML0772 PUTATIVE THYMIDYLATE KINASE from
FT                   Mycobacterium leprae (210 aa), FASTA scores: opt: 1023,
FT                   E(): 4.8e-57, (77.3% identity in 207 aa overlap). Also
FT                   similar to other thymidylate kinases e.g.
FT                   Q9RQJ9|KTHY_CAUCR|TMK|CC1824 from Caulobacter crescentus
FT                   (208 aa), FASTA scores: opt: 179, E(): 0.0003, (31.3%
FT                   identity in 214 aa overlap); Q9V1E9|KTHY_PYRAB|TMK|PAB0319
FT                   from Pyrococcus abyssi (205 aa), FASTA scores: opt: 176,
FT                   E(): 0.00045, (29.1% identity in 189 aa overlap); etc.
FT                   BELONGS TO THE THYMIDYLATE KINASE FAMILY."
FT                   /db_xref="GOA:O05891"
FT                   /db_xref="InterPro:IPR018095"
FT                   /db_xref="PDB:1G3U"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05891"
FT                   /protein_id="CAB08348.1"
FT                   /translation="MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAA
FT                   DIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYS
FT                   AARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARD
FT                   NYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS"
FT   CDS             complement(160497..161984)
FT                   /transl_table=11
FT                   /gene="sahH"
FT                   /locus_tag="Rv3248c"
FT                   /product="PROBABLE ADENOSYLHOMOCYSTEINASE SAHH
FT                   (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE)"
FT                   /function="THIOESTER HYDROLASE WHICH ACTING ON ETHER
FT                   BOUNDS. COULD BE INVOLVED IN METHIONINE AND SELENOAMINO
FT                   ACID METABOLISMS. ALSO INVOLVED IN ACTIVATED METHYL. CYCLE
FT                   ADENOSYLHOMOCYSTEINE IS A COMPETITIVE INHIBITOR OF
FT                   S-ADENOSYL-L-METHIONINE-DEPENDENT METHYL TRANSFERASE
FT                   REACTIONS; THEREFORE ADENOSYLHOMOCYSTEINASE MAY PLAY A KEY
FT                   ROLE IN THE CONTROL OF METHYLATIONS VIA REGULATION OF THE
FT                   INTRACELLULAR CONCENTRATION OF ADENOSYLHOMOCYSTEINE
FT                   [CATALYTIC ACTIVITY: S-ADENOSYL-L-HOMOCYSTEINE + H(2)O =
FT                   ADENOSINE + L-HOMOCYSTEINE]."
FT                   /EC_number="3.3.1.1"
FT                   /note="Rv3248c, (MTCY20B11.23c), len: 495 aa. Probable
FT                   sahH, adenosylhomocysteinase (EC 3.3.1.1), equivalent to
FT                   Q9CCJ4|SAHH|ML0771 PUTATIVE S-ADENOSYL-L-HOMOCYSTEINE
FT                   HYDROLASE from Mycobacterium leprae (492 aa), FASTA scores:
FT                   opt: 3019, E(): 1.3e-177, (91.4% identity in 489 aa
FT                   overlap). Also highly similar to other
FT                   adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces
FT                   coelicolor (485 aa), FASTA scores: opt: 2258, E():
FT                   5.7e-131, (70.0% identity in 483 aa overlap);
FT                   P51540|SAHH_TRIVA from Trichomonas vaginalis (486 aa),
FT                   FASTA scores: opt: 2005, E(): 1.8e-115, (62.05% identity in
FT                   477 aa overlap); P35007|SAHH_CATRO from Catharanthus roseus
FT                   (Rosy periwinkle) (Madagascar periwinkle) (485 aa), FASTA
FT                   scores: opt: 1941, E(): 1.5e-111, (60.15% identity in 492
FT                   aa overlap); etc. Has S-adenosyl-L-homocysteine hydrolase
FT                   signature (PS00739). BELONGS TO THE ADENOSYLHOMOCYSTEINASE
FT                   FAMILY."
FT                   /db_xref="GOA:P60176"
FT                   /db_xref="InterPro:IPR020082"
FT                   /db_xref="PDB:2ZIZ"
FT                   /db_xref="UniProtKB/Swiss-Prot:P60176"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08349.1"
FT                   /translation="MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPG
FT                   LMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAA
FT                   AVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATML
FT                   VLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTG
FT                   VLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLIC
FT                   GYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGN
FT                   KDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSI
FT                   IVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVA
FT                   RIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY"
FT   misc_feature    complement(161118..161162)
FT                   /note="PS00739 S-adenosyl-L-homocysteine hydrolase
FT                   signature"
FT   CDS             complement(162089..162724)
FT                   /transl_table=11
FT                   /locus_tag="Rv3249c"
FT                   /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   (PROBABLY TETR-FAMILY)"
FT                   /function="PROBABLY INVOLVED IN A TRANSCRIPTIONAL
FT                   MECHANISM"
FT                   /note="Rv3249c, (MTCY20B11.24c), len: 211 aa. Possible
FT                   transcriptional regulatory protein, tetR family, with
FT                   similarity to several e.g. Q9AE61|ALKB1 PUTATIVE
FT                   TETR-REGULATORY from Rhodococcus erythropolis (208 aa),
FT                   FASTA scores: opt: 503, E(): 7.7e-26, (40.6% identity in
FT                   192 aa overlap); CAC37620 PUTATIVE TETR-REGULATORY PROTEIN
FT                   from Prauserella rugosa (212 aa), FASTA scores: opt: 246,
FT                   E(): 4.4e-09, (27.95% identity in 186 aa overlap);
FT                   Q9K4B0|SC7E4.06 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from
FT                   Streptomyces coelicolor (203 aa), FASTA scores: opt: 224,
FT                   E(): 1.1e-07, (34.5% identity in 197 aa overlap);
FT                   Q11063|YC55_MYCTU|Rv1255c|MT1294|MTCY50.27 HYPOTHETICAL
FT                   TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis
FT                   (202 aa), FASTA scores: opt: 191, E(): 1.6e-05, (28.35%
FT                   identity in 180 aa overlap); etc. Equivalent to AAK47689
FT                   from Mycobacterium tuberculosis strain CDC1551 (230 aa) but
FT                   shorter 19 aa. COULD BELONG TO THE TETR/ACRR FAMILY OF
FT                   TRANSCRIPTIONAL REGULATORS. Possible helix-turn helix motif
FT                   at aa 44-65 (+6.66 SD)."
FT                   /db_xref="GOA:O05892"
FT                   /db_xref="InterPro:IPR012287"
FT                   /db_xref="UniProtKB/TrEMBL:O05892"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08350.1"
FT                   /translation="MSTPSATVAPVKRIPYAEASRALLRDSVLDAMRDLLLTRDWSAIT
FT                   LSDVARAAGISRQTIYNEFGSRQGLAQGYALRLADRLVDNVHASLDANVGNFYEAFLQG
FT                   FRSFFAESAADPLVISLLTGVAKPDLLQLITTDSAPIITRASARLAPAFTDTWVATTDN
FT                   DANVLSRAIVRLCLSYVSMPPEADHDVAADLARLITPFAERHGVINVP"
FT   CDS             complement(162721..162903)
FT                   /transl_table=11
FT                   /gene="rubB"
FT                   /locus_tag="Rv3250c"
FT                   /product="PROBABLE RUBREDOXIN RUBB"
FT                   /function="INVOLVED IN THE HYDROCARBON HYDROXYLATING SYSTEM
FT                   TO CONVERT CONVERSION OF DODECANE TO LAURIC ACID, WHICH
FT                   TRANSFERS ELECTRONS FROM NADH TO RUBREDOXIN REDUCTASE AND
FT                   THEN THROUGH RUBREDOXIN TO ALKANE 1 MONOOXYGENASE."
FT                   /note="Rv3250c, (MTCY20B11.25c), len: 60 aa. Probable rubB,
FT                   rubredoxin, highly similar to other rubredoxins e.g.
FT                   Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa), FASTA
FT                   scores: opt: 391, E(): 2.2e-21, (83.05% identity in 59 aa
FT                   overlap); Q9AE63|RUBA2 from Rhodococcus erythropolis (63
FT                   aa), FASTA scores: opt: 380, E(): 1.4e-20, (83.9% identity
FT                   in 56 aa overlap); P42453|RUBR_ACICA|RUBA from
FT                   Acinetobacter calcoaceticus (54 aa), FASTA scores: opt:
FT                   315, E(): 4.9e-16, (69.8% identity in 53 aa overlap);
FT                   Q9HTK7|PA5351 from Pseudomonas aeruginosa (55 aa), FASTA
FT                   scores: opt: 298, E(): 8e-15, (64.15% identity in 53 aa
FT                   overlap); Q9PGC3|XF0379 from Xylella fastidiosa (57 aa),
FT                   FASTA scores: opt: 263, E(): 2.5e-12, (59.25% identity in
FT                   54 aa overlap); etc. Also similar to neighbouring ORF M.
FT                   tuberculosis RubA (MTCY20B11.26c). Contains rubredoxin
FT                   signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY."
FT                   /db_xref="GOA:O05893"
FT                   /db_xref="HSSP:1RB9"
FT                   /db_xref="InterPro:IPR018527"
FT                   /db_xref="UniProtKB/TrEMBL:O05893"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08351.1"
FT                   /translation="MNDYKLFRCIQCGFEYDEALGWPEDGIAAGTRWDDIPDDWSCPDC
FT                   GAAKSDFEMVEVARS"
FT   misc_feature    complement(162766..162798)
FT                   /note="PS00202 Rubredoxin signature"
FT   CDS             complement(162908..163075)
FT                   /transl_table=11
FT                   /gene="rubA"
FT                   /locus_tag="Rv3251c"
FT                   /product="PROBABLE RUBREDOXIN RUBA"
FT                   /function="INVOLVED IN THE HYDROCARBON HYDROXYLATING
FT                   SYSTEM, WHICH TRANSFERS ELECTRONS FROM NADH TO RUBREDOXIN
FT                   REDUCTASE AND THEN THROUGH RUBREDOXIN TO ALKANE 1
FT                   MONOOXYGENASE."
FT                   /note="Rv3251c, (MTCY20B11.26c), len: 55 aa. Probable rubA,
FT                   rubredoxin, highly similar to other rubredoxins (but
FT                   sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus
FT                   erythropolis (61 aa), FASTA scores: opt: 335, E(): 1e-17,
FT                   (73.6% identity in 53 aa overlap); P00272|RUB2_PSEOL|ALKG
FT                   from Pseudomonas oleovorans (172 aa), FASTA scores: opt:
FT                   278, E(): 2.7e-13, (65.3% identity in 49 aa overlap);
FT                   CAC38028|ALKG from Alcanivorax borkumensis (174 aa), FASTA
FT                   scores: opt: 271, E(): 8.6e-13, (62.0% identity in 50 aa
FT                   overlap); Q9WWW4|ALKG from Pseudomonas putida (175 aa),
FT                   FASTA scores: opt: 270, E(): 1e-12, (61.8% identity in 55
FT                   aa overlap); etc. Also highly similar to C-terminus of
FT                   Q9XBM1|ALKB ALKANE 1-MONOOXYGENASE (EC 1.14.15.3) from
FT                   Prauserella rugosa (490 aa), FASTA scores: opt: 296, E():
FT                   2.9e-14, (75.5% identity in 49 aa overlap). Also similar to
FT                   neighbouring ORF Mycobacterium tuberculosis rubB
FT                   (MTCY20B11.25c). Contains rubredoxin signature (PS00202).
FT                   BELONGS TO THE RUBREDOXIN FAMILY."
FT                   /db_xref="GOA:O05894"
FT                   /db_xref="HSSP:6RXN"
FT                   /db_xref="InterPro:IPR001052"
FT                   /db_xref="UniProtKB/TrEMBL:O05894"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08322.1"
FT                   /translation="MAAYRCPVCDYVYDEANGDAREGFPAGTGWDQIPDDWCCPDCAVR
FT                   EKVDFEKIGG"
FT   misc_feature    complement(162947..162979)
FT                   /note="PS00202 Rubredoxin signature"
FT   CDS             complement(163075..164325)
FT                   /transl_table=11
FT                   /gene="alkB"
FT                   /locus_tag="Rv3252c"
FT                   /product="PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE
FT                   ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE)
FT                   (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE
FT                   HYDROXYLASE-RUBREDOXIN)"
FT                   /function="THOUGHT TO BE INVOLVED IN FATTY ACID METABOLISM.
FT                   GENERATES OCTANOL AND OXIDIZED RUBREDOXIN FROM OCTANE AND
FT                   REDUCED RUBREDOXIN. ALSO HYDROXYLATES FATTY ACIDS IN THE
FT                   OMEGA-POSITION [CATALYTIC ACTIVITY: OCTANE + REDUCED
FT                   RUBREDOXIN + (O)2 = 1-OCTANOL + OXIDIZED RUBREDOXIN +
FT                   H(2)O]."
FT                   /EC_number="1.14.15.3"
FT                   /note="Rv3252c, (MTCY20B11.27c), len: 416 aa. Probable
FT                   alkB, transmembrane alkane-1-monooxygenase (EC 1.14.15.3),
FT                   highly similar to many (see Marin et al., 2001) e.g.
FT                   Q9AE68|ALKB2 from Rhodococcus erythropolis (408 aa), FASTA
FT                   scores: opt: 2018, E(): 9.6e-122, (68.6% identity in 415 aa
FT                   overlap); Q9AFD5|ALKB from Nocardioides sp. CF8 (483 aa),
FT                   FASTA scores: opt: 1485, E(): 1.4e-87, (56.55% identity in
FT                   405 aa overlap); Q9XAU0|ALKB1 from Rhodococcus erythropolis
FT                   (391 aa), FASTA scores: opt: 1400, E(): 3.3e-82, (62.6%
FT                   identity in 396 aa overlap); Q9XBM1|ALKB from Prauserella
FT                   rugosa (490 aa), FASTA scores: opt: 1266, E(): 1.5e-73,
FT                   (57.55% identity in 410 aa overlap); CAC40954|ALKB4 from
FT                   Rhodococcus erythropolis (386 aa), FASTA scores: opt: 1190,
FT                   E(): 9.1e-69, (54.3% identity in 383 aa overlap); etc."
FT                   /db_xref="GOA:O05895"
FT                   /db_xref="InterPro:IPR005804"
FT                   /db_xref="UniProtKB/TrEMBL:O05895"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08323.1"
FT                   /translation="MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLPL
FT                   IWGMNQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDKYYRYC
FT                   TYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSVGVLGGVGINTAHEM
FT                   GHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRVSTPEDPASARFGETLWEFLPRSV
FT                   IGGLRSAVHLEAQRLRRLGVSPWNPMTYLRNDVLNAWLMSVVLWGGLIAVFGPALIPFV
FT                   IIQAVFGFSLLEAVNYLEHYGLLRQKSANGRYERCAPVHSWNSDHIVTNLFLYHLQRHS
FT                   DHHANPTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDITRVN
FT                   LHPRVREKALARYGASA"
FT   CDS             complement(164434..165921)
FT                   /transl_table=11
FT                   /locus_tag="Rv3253c"
FT                   /product="POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL
FT                   MEMBRANE PROTEIN"
FT                   /function="THOUGHT TO BE INVOLVED IN CATIONIC AMINO ACID
FT                   TRANSPORT ACROSS THE MEMBRANE. RESPONSIBLE FOR THE
FT                   TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE."
FT                   /note="Rv3253c, (MTCY20B11.28c), len: 495 aa. Possible
FT                   cationic amino acid transporter, integral membrane protein,
FT                   similar to many e.g. O69844|SC1C3.02 PUTATIVE CATIONIC
FT                   AMINO ACID TRANSPORTER from Streptomyces coelicolor (503
FT                   aa), FASTA scores: opt: 1649, E(): 5.8e-92, (52.6% identity
FT                   in 485 aa overlap); Q9AE69 PUTATIVE TRANSPORTER (FRAGMENT)
FT                   from Rhodococcus erythropolis (385 aa), FASTA scores: opt:
FT                   1594, E(): 9.7e-89, (62.0% identity in 387 aa overlap);
FT                   Q9PBD7|XF2207 CATIONIC AMINO ACID TRANSPORTER from Xylella
FT                   fastidiosa (483 aa), FASTA scores: opt: 1079, E(): 1.2e-57,
FT                   (40.55% identity in 493 aa overlap); Q9SRU9|F20H23.25
FT                   PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Arabidopsis
FT                   thaliana (Mouse-ear cress) (614 aa), FASTA scores: opt:
FT                   802, E(): 6.7e-41, (36.4% identity in 445 aa overlap);
FT                   P30823|CTR1_RAT|SLC7A1|ATRC1 HIGH-AFFINITY CATIONIC AMINO
FT                   ACID TRANSPORTER-1 from Rattus norvegicus (Rat) (624 aa),
FT                   FASTA scores: opt: 782, E(): 1.1e-39, (36.1% identity in
FT                   432 aa overlap); etc. Relatives in Mycobacterium
FT                   tuberculosis include: MTCY3G12.14, E(): 5.6e-31; MTCY39.19,
FT                   E(): 1.6e-14. SEEMS TO BELONG TO THE APC FAMILY."
FT                   /db_xref="GOA:O05896"
FT                   /db_xref="InterPro:IPR015606"
FT                   /db_xref="UniProtKB/TrEMBL:O05896"
FT                   /protein_id="CAB08324.1"
FT                   /translation="MAGRRRMKSVEQSIADTDEPTTRLRKDLTWWDLVVFGVSVVIGAG
FT                   IFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVAGSAYTFSYATFGEF
FT                   LAWVIGWNLVLELAMGAAVVAKGWSSYLGTVFGFGNGTGHLGSLQLDWGALVIVTLVAT
FT                   LIALGTKLSSRFSAVVTAIKVSVVVLVVVVGAFYIRAANYSPFIPEPEVQHHGGGLDQS
FT                   VFSLLTGAQGSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGILASLGV
FT                   VTLLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGALAGLTTV
FT                   VMVLMLGQCRVLFAMARDGLVPRQLAKTGSRGTPVRVTVLVAVLVATTASVFPITKLEE
FT                   MVNVGTLFAFILVSAGVVVLRRTRPDLQRGFTAPWVPLLPIAAVCACLWLMLNLTALTW
FT                   IRFGIWLVAGTAIYVGYGRRHSAQGLRQARESATRRC"
FT   CDS             166012..167400
FT                   /transl_table=11
FT                   /locus_tag="Rv3254"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3254, (MTCY20B11.29), len: 462 aa. Conserved
FT                   hypothetical protein, similar to CAC37877|SC1G7.02 PUTATIVE
FT                   SECRETED PROTEIN from Streptomyces coelicolor (440 aa),
FT                   FASTA scores: opt: 606, E(): 6.2e-31, (31.7% identity in
FT                   445 aa overlap); O86550|SC1F2.13c HYPOTHETICAL 50.7 KDA
FT                   PROTEIN from Streptomyces coelicolor (476 aa), FASTA
FT                   scores: opt: 577, E(): 4.5e-29, (32.5% identity in 400 aa
FT                   overlap); Q9L0A8|SCC24.09 PUTATIVE SECRETED PROTEIN from
FT                   Streptomyces coelicolor (468 aa), FASTA scores: opt: 380,
FT                   E(): 1.3e-16, (30.7% identity in 391 aa overlap);
FT                   BAB48792|MLL1411 PROBABLE FAD-DEPENDENT MONOOXYGENASE from
FT                   Rhizobium loti (Mesorhizobium loti) (421 aa), FASTA scores:
FT                   opt: 128, E(): 1.1, (25.2% identity in 397 aa overlap);
FT                   Q9L7X9|BENF BENZOATE-SPECIFIC PORIN-LIKE PROTEIN from
FT                   Pseudomonas putida (397 aa), FASTA scores: opt: 119, E():
FT                   4, (24.85% identity in 157 aa overlap); etc. Also similar
FT                   to N-terminus of AAK46259|MT1987 PUTATIVE FERREDOXIN
FT                   REDUCTASE, ELECTRON TRANSFER COMPONENT from Mycobacterium
FT                   tuberculosis strain CDC1551 (839 aa), FASTA scores: opt:
FT                   493, E(): 1.5e-23, (30.65% identity in 382 aa overlap)."
FT                   /db_xref="GOA:O05897"
FT                   /db_xref="InterPro:IPR002937"
FT                   /db_xref="UniProtKB/TrEMBL:O05897"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08325.1"
FT                   /translation="MVIGASIAGLCAARVLSDFYSTVTVFERDELPEAPANRATVPQDR
FT                   HLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENRPDCIYLGAAGHVLGTGHTLRKEFT
FT                   AYVPSRPHLEWQLRRRVLQLSNVQIVRRLVTEPQFERRQQRVVGVLLDSPGSGQDRERE
FT                   EFIAADLVVDAAGRGTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVV
FT                   AGASHDQSLGLGMLCYEDGTWVLTTFGVADAKPPPTFDEMRALADKLLPARFTAALAQA
FT                   QPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGMTMTSLQAGHLRR
FT                   ALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDISFHHATAEPLPRWWRPAGSLFD
FT                   QFLGAAETDPVLAEWFLRRFSLLDSLYMVPSVPIIGRAIAHNLRLWLKEQRERRQPVTT
FT                   RRSP"
FT   CDS             complement(167378..168604)
FT                   /transl_table=11
FT                   /gene="manA"
FT                   /locus_tag="Rv3255c"
FT                   /product="PROBABLE MANNOSE-6-PHOSPHATE ISOMERASE MANA
FT                   (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI)
FT                   (PHOSPHOHEXOISOMERASE) (PHOSPHOHEXOMUTASE)"
FT                   /function="THIS ENZYME CONVERTS D-MANNOSE 6-PHOSPHATE TO
FT                   D-FRUCTOSE 6-PHOSPHATE [CATALYTIC ACTIVITY: D-MANNOSE
FT                   6-PHOSPHATE = D-FRUCTOSE 6-PHOSPHATE]."
FT                   /EC_number="5.3.1.8"
FT                   /note="Rv3255c, (MTCY20B11.30c), len: 408 aa. Probable
FT                   manA, mannose-6-phosphate isomerase (EC 5.3.1.8),
FT                   equivalent to Q9CCJ5|MANA|ML0765 PUTATIVE
FT                   MANNOSE-6-PHOSPHATE ISOMERASE from Mycobacterium leprae
FT                   (410 aa), FASTA scores: opt: 2271, E(): 1.6e-133, (84.45%
FT                   identity in 411 aa overlap). Also similar to many others
FT                   e.g. Q9KZL9|MANA from Streptomyces coelicolor (383 aa),
FT                   FASTA scores: opt: 946, E(): 2.4e-51, (44.4% identity in
FT                   403 aa overlap); Q9KV87|VC0269 from Vibrio cholerae (399
FT                   aa), FASTA scores: opt: 726, E(): 1.1e-37, (34.15% identity
FT                   in 404 aa overlap); Q9CMJ5|PMI|PM0829 from Pasteurella
FT                   multocida (400 aa), FASTA scores: opt: 640, E(): 2.4e-32,
FT                   (32.5% identity in 391 aa overlap); etc. SIMILAR TO FAMILY
FT                   1 OF MANNOSE-6-PHOSPHATE ISOMERASES."
FT                   /db_xref="GOA:O05898"
FT                   /db_xref="HSSP:1PMI"
FT                   /db_xref="InterPro:IPR016305"
FT                   /db_xref="UniProtKB/TrEMBL:O05898"
FT                   /protein_id="CAB08326.1"
FT                   /translation="MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDP
FT                   AWLQTPHGQTSLLEALVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHPSAEQ
FT                   AVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRALAV
FT                   SDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAE
FT                   AKTVLELGERYPGDAGVLAALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNV
FT                   LRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGD
FT                   HLGHEVDASSGHDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPA
FT                   KLFRATVGL"
FT   CDS             complement(168612..169652)
FT                   /transl_table=11
FT                   /locus_tag="Rv3256c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa.
FT                   Conserved hypothetical protein, equivalent to Q9CCJ6|ML0764
FT                   HYPOTHETICAL PROTEIN from Mycobacterium leprae (365 aa),
FT                   FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in
FT                   365 aa overlap). Also similar to other hypothetical
FT                   bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces
FT                   coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012,
FT                   (31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from
FT                   Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt:
FT                   140, E(): 0.84, (28.75% identity in 233 aa overlap).
FT                   TBparse score is 0.878."
FT                   /db_xref="UniProtKB/TrEMBL:O05899"
FT                   /protein_id="CAB08352.1"
FT                   /translation="MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGE
FT                   LDLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVLIV
FT                   AGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFGLSR
FT                   YLAAGLAALQTVDPKLRIDLASLADELDAEALRNSAGREVFTNPAKALAARVSGCQLAL
FT                   AGDNAATLALARHGSSVMLRIANQVVAATRLSDAVVALRAGTPPDALFHDEEIDGPAPQ
FT                   RLRVLALALAGERTVVAARVAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRLEMAAVY
FT                   LRLVRG"
FT   CDS             complement(169649..171046)
FT                   /transl_table=11
FT                   /gene="pmmA"
FT                   /locus_tag="Rv3257c"
FT                   /product="PROBABLE PHOSPHOMANNOMUTASE PMMA (PMM)
FT                   (PHOSPHOMANNOSE MUTASE)"
FT                   /function="THIS ENZYME CONVERSES D-MANNOSE 1-PHOSPHATE IN
FT                   D-MANNOSE 6-PHOSPHATE [CATALYTIC ACTIVITY: D-MANNOSE
FT                   1-PHOSPHATE = D-MANNOSE 6-PHOSPHATE]."
FT                   /EC_number="5.4.2.8"
FT                   /note="Rv3257c, (MTV015.02c), len: 465 aa. Probable pmmA,
FT                   phosphomannomutase (EC 5.4.2.8), equivalent to
FT                   Q9CCJ7|PMMA|ML0763 PHOSPHOMANNOMUTASE from Mycobacterium
FT                   leprae (468 aa), FASTA scores: opt: 2533, E(): 2e-145,
FT                   (83.1% identity in 468 aa overlap). Also similar to many
FT                   e.g. Q9KZL6|MANB from Streptomyces coelicolor (454 aa),
FT                   FASTA scores: opt: 1820, E(): 2e-102, (63.2% identity in
FT                   459 aa overlap); Q9PGN8|XF0260 from Xylella fastidiosa (500
FT                   aa), FASTA scores: opt: 1085, E(): 4.7e-58, (40.7% identity
FT                   in 462 aa overlap); Q9EY19|MANB from Salmonella enterica
FT                   subsp. arizonae (456 aa), FASTA scores: opt: 988, E():
FT                   3.1e-52, (38.65% identity in 445 aa overlap); etc. BELONGS
FT                   TO THE PHOSPHOHEXOSE MUTASES FAMILY. TBparse score is
FT                   0.903."
FT                   /db_xref="GOA:O86374"
FT                   /db_xref="HSSP:1K2Y"
FT                   /db_xref="InterPro:IPR016055"
FT                   /db_xref="UniProtKB/TrEMBL:O86374"
FT                   /protein_id="CAB08353.1"
FT                   /translation="MSWPAAAVDRVIKAYDVRGLVGEEIDESLVTDLGAAFARLMRTED
FT                   ARPVVIGHDMRDSSPSLADAFAAGVTGQGLDVVRVGLASTDQLYFASGLLDCPGAMFTA
FT                   SHNPAAYNGIKMCRAAAKPVGADTGLTAIRDDLIAGVARYDGTPGTIADQDVLVDYGAF
FT                   LRSLVDTSGLRPLRVAVDAGNGMAGHTAPAVLGVIDSITLLPSYFELDGSFPNHEANPL
FT                   DPANLVDLQAYVRDTGADIGLAFDGDADRCFVVDERGQPVSPSTVTALVAARELNREIG
FT                   ATIIHNVITSRAVPELVAERGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHYYFRDFW
FT                   GADSGMLAALHVLAALGEQSRPLSELTADYQRYESSGEINFTVVDSSACVEAVLKSFGN
FT                   RIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVEGRSVGDVDAVVRQVSAEIAAQS
FT                   AHAKAGP"
FT   CDS             complement(171148..171639)
FT                   /transl_table=11
FT                   /locus_tag="Rv3258c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3258c, (MTV015.03c), len: 163 aa. Conserved
FT                   hypothetical protein, equivalent to Q9CCJ8|ML0762
FT                   HYPOTHETICAL PROTEIN from Mycobacterium leprae (165 aa),
FT                   FASTA scores: opt: 840, E(): 9.9e-42, (76.9% identity in
FT                   169 aa overlap). Also similar to Q9KZL4|SCE34.11c
FT                   HYPOTHETICAL 15.0 KDA PROTEIN from Streptomyces coelicolor
FT                   (140 aa), FASTA scores: opt: 353, E(): 1.1e-13, (48.3%
FT                   identity in 147 aa overlap); and shows really weak
FT                   similarity to other bacterial proteins. TBparse score is
FT                   0.928."
FT                   /db_xref="UniProtKB/TrEMBL:O53351"
FT                   /protein_id="CAA17072.1"
FT                   /translation="MRVSGASAALVHDSLSVVNVPRRCCRPGCPHYAVATLTFVYSDST
FT                   AVIGPLATAREPHSWDLCVGHAGRITAPRGWELVRHAGPLPSHPDEDDLVALADAVREG
FT                   GPSAGRRHHPGGNGAPLHGFDDFPAAATGAPTGGGVLAPPEPGAGRRRGHLRVLPDPAD
FT                   "
FT   CDS             171762..172181
FT                   /transl_table=11
FT                   /locus_tag="Rv3259"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3259, (MTV015.04), len: 139 aa. Conserved
FT                   hypothetical protein, equivalent, but shorter 29 aa, to
FT                   Q9CCJ9|ML0761 HYPOTHETICAL PROTEIN from Mycobacterium
FT                   leprae (167 aa), FASTA scores: opt: 846, E(): 2.2e-47,
FT                   (89.2% identity in 139 aa overlap). C-terminus highly
FT                   similar to Q9S425 HYPOTHETICAL 6.0 KDA PROTEIN (FRAGMENT)
FT                   from Mycobacterium smegmatis (54 aa), FASTA scores: opt:
FT                   275, E(): 2.7e-11, (81.15% identity in 53 aa overlap). Also
FT                   similar to Q9KZL3|SCE34.12 from Streptomyces coelicolor
FT                   (117 aa), FASTA scores: opt: 152, E(): 0.004, (34.15%
FT                   identity in 126 aa overlap). Equivalent to AAK47699 from
FT                   Mycobacterium tuberculosis strain CDC1551 (175 aa) but
FT                   shorter 36 aa. TBparse score is 0.884."
FT                   /db_xref="UniProtKB/TrEMBL:O53352"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17073.1"
FT                   /translation="MRGPLLPPTVPGWRSRAERFDMAVLEAYEPIERRWQERVSQLDIA
FT                   VDEIPRIAAKDPESVQWPPEVIADGPIALARLIPAGVDVRGNATRARIVLFRKPIERRA
FT                   KDTEELGELLHEILVAQVAIYLDVDPSVIDPTIDD"
FT   CDS             complement(172209..172478)
FT                   /transl_table=11
FT                   /gene="whiB2"
FT                   /locus_tag="Rv3260c"
FT                   /standard_name="whmD"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   WHIB-LIKE WHIB2"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv3260c, (MTV015.05c), len: 89 aa. Probable whiB2
FT                   (alternate gene name: whmD), WhiB-like regulatory protein
FT                   (see Hutter & Dick 1999), similar to WhiB paralogue of
FT                   Streptomyces coelicolor, wblE gene product (85 aa).
FT                   Equivalent to Q9CCK0|WHIB2|ML0760 PUTATIVE TRANSCRIPTIONAL
FT                   REGULATOR from Mycobacterium leprae (89 aa), FASTA scores:
FT                   opt: 550, E(): 6.1e-31, (85.4% identity in 89 aa overlap).
FT                   Also similar to others e.g. Q9S426 WHMD REGULATORY PROTEIN
FT                   (see Gomez & Bishai 2000) from Mycobacterium smegmatis (129
FT                   aa), FASTA scores: opt: 488, E(): 1.4e-26, (83.55% identity
FT                   in 85 aa overlap); Q06387|WHIB-STV WHIB-STV PROTEIN from
FT                   Streptomyces griseocarneus (87 aa), FASTA scores: opt: 443,
FT                   E(): 1.2e-23, (74.7% identity in 83 aa overlap);
FT                   Q05429|WHIB|WHIB1 TRANSCRIPTION-LIKE FACTOR WHIB from
FT                   Streptomyces aureofaciens (87 aa), FASTA scores: opt: 442,
FT                   E(): 1.3e-23, (74.7% identity in 83 aa overlap); etc.
FT                   Equivalent to AAK47700 WhiB-related protein from
FT                   Mycobacterium tuberculosis strain CDC1551 (123 aa) but
FT                   shorter 34 aa. Also similar to other Mycobacterium
FT                   tuberculosis proteins: MTCY07D11.07c (45.1% identity in 71
FT                   aa overlap) and MTCY78.13c (37.4% identity in 91 aa
FT                   overlap). Start chosen by homology but ORF continues to ATG
FT                   upstream at 3754."
FT                   /db_xref="InterPro:IPR003482"
FT                   /db_xref="UniProtKB/TrEMBL:O53353"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17074.1"
FT                   /translation="MVPEAPAPFEEPLPPEATDQWQDRALCAQTDPEAFFPEKGGSTRE
FT                   AKKICMGCEVRHECLEYALAHDERFGIWGGLSERERRRLKRGII"
FT   CDS             172880..173875
FT                   /transl_table=11
FT                   /gene="fbiA"
FT                   /locus_tag="Rv3261"
FT                   /product="PROBABLE F420 BIOSYNTHESIS PROTEIN FBIA"
FT                   /function="REQUIRED FOR COENZYME F420 PRODUCTION: INVOLVED
FT                   IN THE CONVERSION OF FO INTO F420."
FT                   /note="Rv3261, (MTCY71.01), len: 331 aa. Probable fbiA,
FT                   F420 biosynthesis protein, equivalent to FBIA F420
FT                   biosynthesis protein fbiA from Mycobacterium bovis BCG (see
FT                   citations below). Also equivalent, but shorter 46 aa, to
FT                   Q9CCK1|ML0759 HYPOTHETICAL PROTEIN from Mycobacterium
FT                   leprae (379 aa), FASTA scores: opt: 1855, E(): 3.9e-110,
FT                   (79.3% identity in 333 aa overlap). Also similar to others
FT                   e.g. Q9KZK9|SCE34.17 HYPOTHETICAL 33.6 KDA PROTEIN from
FT                   Streptomyces coelicolor (319 aa), FASTA scores: opt: 1151,
FT                   E(): 1.2e-65, (55.1% identity in 332 aa overlap);
FT                   O29345|AF0917 CONSERVED HYPOTHETICAL PROTEIN from
FT                   Archaeoglobus fulgidus (296 aa), FASTA scores: opt: 469,
FT                   E(): 1.7e-22, (31.15% identity in 302 aa overlap);
FT                   Q58653|MJ1256 HYPOTHETICAL PROTEIN from Methanococcus
FT                   jannaschii (311 aa), FASTA scores: opt: 436, E(): 2.2e-20,
FT                   (27.35% identity in 274 aa overlap); etc."
FT                   /db_xref="GOA:P96866"
FT                   /db_xref="InterPro:IPR010115"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96866"
FT                   /protein_id="CAB07094.1"
FT                   /translation="MKVTVLAGGVGGARFLLGVQQLLGLGQFAANSAHSDADHQLSAVV
FT                   NVGDDAWIHGLRVCPDLDTCMYTLGGGVDPQRGWGQRDETWHAMQELVRYGVQPDWFEL
FT                   GDRDLATHLVRTQMLQAGYPLSQITEALCDRWQPGARLLPATDDRCETHVVITDPVDES
FT                   RKAIHFQEWWVRYRAQVPTHSFAFVGAEKSSAATEAIAALADADIIMLAPSNPVVSIGA
FT                   ILAVPGIRAALREATAPIVGYSPIIGEKPLRGMADTCLSVIGVDSTAAAVGRHYGARCA
FT                   TGILDCWLVHDGDHAEIDGVTVRSVPLLMTDPNATAEMVRAGCDLAGVVA"
FT   CDS             173872..175218
FT                   /transl_table=11
FT                   /gene="fbiB"
FT                   /locus_tag="Rv3262"
FT                   /product="PROBABLE F420 BIOSYNTHESIS PROTEIN FBIB"
FT                   /function="REQUIRED FOR COENZYME F420 PRODUCTION: INVOLVED
FT                   IN THE CONVERSION OF FO INTO F420."
FT                   /note="Rv3262, (MTCY71.02), len: 448 aa. Probable fbiB,
FT                   F420 biosynthesis protein, equivalent to FBIB F420
FT                   biosynthesis protein fbiB from Mycobacterium bovis BCG (see
FT                   citations below). Also equivalent to Q9CCK2|ML0758 PUTATIVE
FT                   OXIDOREDUCTASE from Mycobacterium leprae (457 aa), FASTA
FT                   scores: opt: 2411, E(): 3.5e-137, (82.25% identity in 445
FT                   aa overlap). Also similar to Q9KZK8|SCE34.18 PUTATIVE
FT                   OXIDOREDUCTASE from Streptomyces coelicolor (443 aa), FASTA
FT                   scores: opt: 1180, E(): 2.2e-63, (51.75% identity in 433 aa
FT                   overlap); other oxidoreductases in C-terminus; and several
FT                   hypothetical bacterial proteins."
FT                   /db_xref="GOA:P96867"
FT                   /db_xref="InterPro:IPR000415"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96867"
FT                   /protein_id="CAB07089.1"
FT                   /translation="MTGPEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLRDGDV
FT                   VVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDRTLITENRLGLVQA
FT                   AAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLGVTVAVVITDTMGRAWRNGQTDA
FT                   AVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAAAADLVKGKLTATPVAVVRGFGV
FT                   SDDGSTARQLLRPGANDLFWLGTAEALELGRQQAQLLRRSVRRFSTDPVPGDLVEAAVA
FT                   EALTAPAPHHTRPTRFVWLQTPAIRARLLDRMKDKWRSDLTSDGLPADAIERRVARGQI
FT                   LYDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVRGLGSCWIG
FT                   STIFAADLVRDELDLPVDWEPLGAIAIGYADEPSGLRDPVPAADLLILK"
FT   CDS             175514..177175
FT                   /transl_table=11
FT                   /locus_tag="Rv3263"
FT                   /product="PROBABLE DNA METHYLASE (MODIFICATION METHYLASE)
FT                   (METHYLTRANSFERASE)"
FT                   /function="CAUSES DNA METHYLATION."
FT                   /EC_number="2.1.1.-"
FT                   /note="Rv3263, (MTCY71.03), len: 553 aa. Probable DNA
FT                   methylase (EC 2.1.1.-), equivalent to Q9CCK4|ML0756
FT                   PROBABLE DNA METHYLASE from Mycobacterium leprae (555 aa),
FT                   FASTA scores: opt: 2980, E(): 2.1e-184, (81.9% identity in
FT                   541 aa overlap). Also similar to others e.g.
FT                   P25240|MT57_ECOLI|ECO57IM MODIFICATION METHYLASE from
FT                   Escherichia coli (544 aa), FASTA scores: opt: 595, E():
FT                   1e-30, (30.35% identity in 507 aa overlap);
FT                   P25201|MTA1_ACICA|ACCIM MODIFICATION METHYLASE ACCI from
FT                   Acinetobacter calcoaceticus (540 aa), FASTA scores: opt:
FT                   366, E(): 5.7e-16, (23.35% identity in 467 aa overlap);
FT                   Q56752|M-ACCI ACCI METHYLASE from Bergeyella zoohelcum (541
FT                   aa), FASTA scores: opt: 365, E(): 6.6e-16, (22.95% identity
FT                   in 466 aa overlap); etc. Contains PS00092 N-6
FT                   Adenine-specific DNA methylases signature. Alternative
FT                   start site at aa 25."
FT                   /db_xref="GOA:P96868"
FT                   /db_xref="InterPro:IPR002296"
FT                   /db_xref="UniProtKB/TrEMBL:P96868"
FT                   /protein_id="CAB07090.1"
FT                   /translation="MQPSHPTRPGAVIRYVGSSLDTCPMTTFAGKTAASADKVRGGYYT
FT                   PPAVARFLAHWVHQAGPKILEPSCGDGRILRELSAITDHAHGVELVAREAKKSRDFASV
FT                   DTENLFTWLHKTQLGSWDGVAGNPPYIRFGNWASEQRDPALELMRRVGLRPTKLTNAWV
FT                   PFVVASTTLARDGGRVGLVVPAELLQVTYAAQLREFLLSRYREITLVTFERLVFDGILQ
FT                   EVVLFCGVVGPGPAHIRTVRLGDANDLNALGDKDFTNESAPALLHEKEKWTKYFLDPAQ
FT                   IRLLRGLKQSATMIRLGELADVDVGIVTGRNSFFTFTDAKAQALGLRAHCVPLVSRSAQ
FT                   LSGLIYDEDCRACDVAGNHRTWLLDAADYPTDPALVAHITAGEAAGVHLGYKCSIRKPW
FT                   WSTPSLWMPDLFMLRQIHFAPRLTVNAAAATSTDTVHRVRLDPNVDPATLAAVFHNSAT
FT                   FAFAEIMGRSYGGGILELEPREAEQLPMPPPAYGSAELAQDVDLLLKANEIDKALDVVD
FT                   RHVLIDGLGLSPRLVAGCRAAWLTLRDRRTKRGSRR"
FT   misc_feature    175883..175903
FT                   /note="PS00092 N-6 Adenine-specific DNA methylases
FT                   signature"
FT   CDS             complement(177235..178314)
FT                   /transl_table=11
FT                   /gene="manB"
FT                   /locus_tag="Rv3264c"
FT                   /standard_name="hddC"
FT                   /product="D-ALPHA-D-MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE
FT                   MANB (D-ALPHA-D-HEPTOSE-1-PHOSPHATE GUANYLYLTRANSFERASE)"
FT                   /function="INVOLVED IN GDP-MANNOSE BIOSYNTHESIS AND
FT                   BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE
FT                   (D-ALPHA-D PATHWAY): GENERATES GDP-MANNOSE AND PHOSPHATE
FT                   FROM GTP AND ALPHA-D-MANNOSE 1-PHOSPHATE. MANB PRODUCT IS
FT                   NEEDED FOR ALL MANNOSYL GLYCOLIPIDS AND POLYSACCHARIDES
FT                   WHICH, LIKE RHAMNOSYL RESIDUES, ARE AN IMPORTANT PART OF
FT                   THE MYCOBACTERIUM ENVELOPE [CATALYTIC ACTIVITY:
FT                   ALPHA-D-MANNOSE 1-PHOSPHATE + GTP = GDP-MANNOSE +
FT                   PHOSPHATE]."
FT                   /EC_number="2.7.7.-"
FT                   /note="Rv3264c, (MTCY71.04c), len: 359 aa. manB (alternate
FT                   gene name: hddC), D-alpha-D-mannose-1-phosphate
FT                   guanylyltransferase (EC 2.7.7.-) (see citations below),
FT                   equivalent to Q9CCK6|RMLA2|ML0753 PUTATIVE SUGAR-PHOSPHATE
FT                   NUCLEOTIDYL TRANSFERASE from Mycobacterium leprae (358 aa),
FT                   FASTA scores: opt: 2075, E(): 2.7e-115, (86.9% identity in
FT                   359 aa overlap). Also similar to others e.g.
FT                   Q9KZK6|SCE34.20c PUTATIVE NUCLEOTIDE PHOSPHORYLASE from
FT                   Streptomyces coelicolor (360 aa), FASTA scores: opt: 1314,
FT                   E(): 2.2e-70, (57.0% identity in 358 aa overlap);
FT                   Q9KZP4|SC1A8A.08 PUTATIVE MANNOSE-1-PHOSPHATE
FT                   GUANYLTRANSFERASE from Streptomyces coelicolor (831 aa),
FT                   FASTA scores: opt: 699, E(): 8.6e-34, (34.45% identity in
FT                   354 aa overlap) (only similarity in N-terminus for this
FT                   one); P74589|SLL1496 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE
FT                   from Synechocystis sp. strain PCC 6803 (843 aa), FASTA
FT                   scores: opt: 692, E(): 2.3e-33, (35.1% identity in 342 aa
FT                   overlap) (only similarity in N-terminus for this one too);
FT                   BAB59222|TVG0079558 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE
FT                   from Thermoplasma volcanium (359 aa), FASTA scores: opt:
FT                   664, E(): 5.2e-32, (34.6% identity in 338 aa overlap);
FT                   Q9ZTW5|GMP GDP-MANNOSE PYROPHOSPHORYLASE from Solanum
FT                   tuberosum (Potato) (361 aa), FASTA scores: opt: 636, E():
FT                   2.3e-30, (34.65% identity in 361 aa overlap); etc. BELONGS
FT                   TO FAMILY 2 OF MANNOSE-6-PHOSPHATE ISOMERASES. Note that
FT                   previously known as rmlA2."
FT                   /db_xref="GOA:Q7D5T3"
FT                   /db_xref="InterPro:IPR005835"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D5T3"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55575.1"
FT                   /translation="MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSR
FT                   IAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRND
FT                   TAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEK
FT                   TEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRD
FT                   MGTPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGP
FT                   GTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGA
FT                   RVWPGVFLPDGGIRYSSDV"
FT   CDS             complement(178316..179221)
FT                   /transl_table=11
FT                   /gene="wbbL1"
FT                   /locus_tag="Rv3265c"
FT                   /standard_name="wbbL"
FT                   /product="PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL
FT                   POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WBBL1
FT                   (ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENY
FT                   L)"
FT                   /function="PROBABLY INVOLVED IN CELL WALL ARABINOGALACTAN
FT                   LINKER FORMATION: USES DTDP-L-RHAMNOSE AS SUBSTRATE TO
FT                   INSERT THE RHAMNOSYL RESIDUE INTO THE CELL WALL. SEEMS TO
FT                   BE ESSENTIAL FOR MYCOBACTERIAL VIABILITY."
FT                   /EC_number="2.-.-.-"
FT                   /note="Rv3265c, (MTCY71.05c), len: 301 aa. Probable wbbL1,
FT                   dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL
FT                   TRANSFERASE (EC 2.-.-.-) (see citations below), equivalent
FT                   to Q9CCK7|WBBL|ML0752 PUTATIVE DTDP-RHAMNOSYL TRANSFERASE
FT                   from Mycobacterium leprae (308 aa), FASTA scores: opt:
FT                   1788, E(): 3e-104, (85.05% identity in 301 aa overlap); and
FT                   Q9RN50|WBBL|Q9RN49 (see note * below)
FT                   DTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL,
FT                   A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium smegmatis
FT                   (296 aa), FASTA scores: opt: 1494, E(): 6.1e-86, (72.35%
FT                   identity in 293 aa overlap). Note that previously known as
FT                   wbbL. [* Note: UNPUBLISHED (experimental study on
FT                   Mycobacterium smegmatis). Submitted (SEP-1999) to the
FT                   EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan
FT                   linker formation enzyme, dTDP-Rha:a-D-GlcNAc-diphosphoryl
FT                   polyprenol, a-3-L-rhamnosyl transferase is essential for
FT                   mycobacterial viability - Mills J.A., Motichka K., Jucker
FT                   M., Wu H.P., Uhlic B.C., Stern R.J., Scherman M.S., Vissa
FT                   V.D., Yan W., Pan F., Kimbrel S., Kundu M., McNeil M.]."
FT                   /db_xref="GOA:Q7D5T2"
FT                   /db_xref="InterPro:IPR001173"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D5T2"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55576.1"
FT                   /translation="MVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAAV
FT                   QRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGSID
FT                   ALLDAASRWPRAGALGPLIRDPDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTTAYR
FT                   QERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWLSVYV
FT                   PSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLALRSHLM
FT                   VRSSLRRSRRRKLKLVEGRH"
FT   CDS             complement(179232..180146)
FT                   /transl_table=11
FT                   /gene="rmlD"
FT                   /locus_tag="Rv3266c"
FT                   /product="dTDP-6-DEOXY-L-LYXO-4-HEXULOSE REDUCTASE RMLD
FT                   (dTDP-RHAMNOSE MODIFICATION PROTEIN) (dTDP-RHAMNOSE
FT                   BIOSYNTHESIS PROTEIN) (dTDP-RHAMNOSE SYNTHASE)"
FT                   /function="INVOLVED IN dTDP-L-RHAMNOSE BIOSYNTHESIS:
FT                   CONVERTS dTDP-6-DEOXY-L-LYXO-4-HEXULOSE TO dTDP-L-RHAMNOSE
FT                   WITH THE CONCOMITANT OXIDATION OF NADPH TO NADP+ [CATALYTIC
FT                   ACTIVITY: dTDP-6-DEOXY-L-LYXO-4-HEXULOSE + NADPH =
FT                   dTDP-L-RHAMNOSE + NADP+]."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv3266c, (MTCY71.06c), len: 304 aa. rmlD,
FT                   dTDP-6-deoxy-L-lyxo-4-hexulose reductase (dTDP-rhamnose
FT                   modification protein) (EC 1.-.-.-)(see citations below),
FT                   highly similar to Q9CCK8 putative dTDP-rhamnose
FT                   modification protein from Mycobacterium leprae (311 aa),
FT                   FASTA scores, opt: 1440, E(): 1.1e-78, (74.7% identity in
FT                   312 aa overlap); and similar to several
FT                   dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) e.g.
FT                   STRL_STRGR|P29781 from Streptomyces griseus (304 aa), FASTA
FT                   scores, opt: 788, E(): 0, (47.4% identity in 304 aa
FT                   overlap)."
FT                   /db_xref="GOA:P96871"
FT                   /db_xref="HSSP:1KBZ"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:P96871"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07093.1"
FT                   /translation="MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDP
FT                   AAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVST
FT                   DYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGT
FT                   GKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVV
FT                   SRFGQARAVFEECGADPQRVRPVSSAQFPRPAPRSSYSALSSRQWALAGLTPLRHWRSA
FT                   LATALAAPANSTSIDRRLPSTRD"
FT   CDS             180222..181718
FT                   /transl_table=11
FT                   /locus_tag="Rv3267"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN (CPSA-RELATED
FT                   PROTEIN)"
FT                   /function="UNKNOWN"
FT                   /note="Rv3267, (MTCY71.07), len: 498 aa. Conserved
FT                   hypothetical protein, CPSA-related protein, equivalent to
FT                   Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium
FT                   leprae (489 aa), FASTA scores: opt: 2523, E(): 5e-138,
FT                   (78.9% identity in 498 aa overlap); and Q50160|CPSA
FT                   (HYPOTHETICAL PROTEIN CPSA) from Mycobacterium leprae (516
FT                   aa), FASTA scores: opt: 868, E(): 1.2e-42, (34.7% identity
FT                   in 507 aa overlap). Also similar to
FT                   O06347|CPSA|Rv3484|MTCY13E12.37 CPSA from Mycobacterium
FT                   tuberculosis (512 aa), FASTA scores: opt: 928, E():
FT                   4.2e-46, (37.35% identity in 498 aa overlap); and
FT                   O53834|Rv0822c|MTV043.14c HYPOTHETICAL 72.9 KDA PROTEIN
FT                   from Mycobacterium tuberculosis (684 aa), FASTA scores:
FT                   opt: 434, E(): 1.5e-17, (30.9% identity in 541 aa overlap).
FT                   Also similar to Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL
FT                   PROTEIN from Streptomyces coelicolor (507 aa), FASTA
FT                   scores: opt: 437, E(): 8.1e-18, (28.55% identity in 469 aa
FT                   overlap); O68907 FRNA PROTEIN from Streptomyces roseofulvus
FT                   (770 aa), FASTA scores: opt: 388, E(): 7.6e-15, (32.6%
FT                   identity in 267 aa overlap); etc. Contains PS00017
FT                   ATP/GTP-binding site motif A."
FT                   /db_xref="InterPro:IPR004474"
FT                   /db_xref="UniProtKB/TrEMBL:P96872"
FT                   /protein_id="CAB07086.1"
FT                   /translation="MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFH
FT                   MSAPSLGHGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILIRV
FT                   PNNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAAGTE
FT                   AGREALIKTVADLTGVTVDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGADFPAG
FT                   RQKLNGPQALSFVRQRHDLPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLKRLEQA
FT                   VQRSVVLSSGWDIMDFVRQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQD
FT                   WVVGLLHEQDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNND
FT                   GDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLANDYSGPGSGLGG
FT                   SDPNGVVSPARAFNLGSADDTTPPPSPILTAGSDAPECIN"
FT   misc_feature    180588..180611
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   CDS             181757..182446
FT                   /transl_table=11
FT                   /locus_tag="Rv3268"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3268, (MTCY71.08), len: 229 aa. Conserved
FT                   hypothetical protein, similar to Q9KZK4|SCE34.22
FT                   HYPOTHETICAL 27.1 KDA PROTEIN from Streptomyces coelicolor
FT                   (263 aa), FASTA scores: opt: 442, E(): 5.9e-20, (40.1%
FT                   identity in 242 aa overlap). Also weak similarity to
FT                   N-terminal part (approximatively 1530 to 1740 residues) of
FT                   O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from
FT                   Streptomyces pristinaespiralis (4848 aa), FASTA scores:
FT                   opt: 159, E(): 0.11, (30.35% identity in 224 aa overlap)."
FT                   /db_xref="GOA:P96873"
FT                   /db_xref="InterPro:IPR017523"
FT                   /db_xref="UniProtKB/TrEMBL:P96873"
FT                   /protein_id="CAB07087.1"
FT                   /translation="MLRADPVGPRITYYDDATGERIELSAVTLANWAAKTGNLLRDELA
FT                   AGPASRVAILLPAHWQTAAVLFGVWWIGAQAILDDSPADVALCTADRLAEADAVVNSAA
FT                   VAGEVAVLSLDPFGRPATGLPVGVTDYATAVRVHGDQIVPEHNPGPVLAGRSVEQILRD
FT                   CAASAAARGLTAADRVLSTASWAGPDELVDGLLAILAAGASLVQVANPDPAMLQRRIAT
FT                   EKVTRVL"
FT   CDS             182571..182852
FT                   /transl_table=11
FT                   /locus_tag="Rv3269"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN. MAY BE INVOLVED IN A CHAPERONING
FT                   PROCESS."
FT                   /note="Rv3269, (MTCY71.09), len: 93 aa. Conserved
FT                   hypothetical protein, similar to many Mycobacterium
FT                   proteins and chaperonins/heat shock proteins e.g.
FT                   Q9CCL0|ML0748 HYPOTHETICAL PROTEIN from Mycobacterium
FT                   leprae (92 aa), FASTA scores: opt: 427, E(): 6.8e-21,
FT                   (73.65% identity in 91 aa overlap);
FT                   Q10865|Rv1993c|MT2049|MTCY39.26c HYPOTHETICAL PROTEIN from
FT                   Mycobacterium tuberculosis (90 aa), FASTA scores: opt: 313,
FT                   E(): 1.2e-13, (60.7% identity in 84 aa overlap);
FT                   P71542|Y968_MYCTU|Rv0968|MTCY10D7.06c (98 aa), FASTA
FT                   scores: opt: 294, E(): 2.2e-12, (55.1% identity in 98 aa
FT                   overlap); Q50827|MOPA|GROEL|CH60_MYCVA CHAPERONIN (PROTEIN
FT                   CPN60) from Mycobacterium vaccae (120 aa), FASTA scores:
FT                   opt: 107, E(): 2.1, (39.5% identity in 81 aa overlap);
FT                   Q9AEB3|HSP65 HEAT SHOCK PROTEIN (FRAGMENT) from
FT                   Mycobacterium gadium (122 aa), FASTA scores: opt: 102, E():
FT                   4.4, (38.25% identity in 81 aa overlap);
FT                   Q49374|CH60_MYCGN|MOPA|GROEL CHAPERONIN (PROTEIN CPN60)
FT                   from Mycobacterium genavense (120 aa), FASTA scores: opt:
FT                   99, E(): 6.8, (40.25% identity in 82 aa overlap); etc."
FT                   /db_xref="InterPro:IPR009963"
FT                   /db_xref="UniProtKB/TrEMBL:P96874"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07088.1"
FT                   /translation="MAIQVFLAKATTTVITGLAGVTAYEILKKAAAKAPLRQTAVSAAA
FT                   LGLRGTRKAEEAAESARLKVADVMAEARERIGEESPTPAISDLHDHDH"
FT   CDS             182863..185019
FT                   /transl_table=11
FT                   /gene="ctpC"
FT                   /locus_tag="Rv3270"
FT                   /product="PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE
FT                   C CTPC"
FT                   /function="METAL CATION-TRANSPORTING ATPASE; POSSIBLY
FT                   CATALYZES THE TRANSPORT OF UNDETERMINED METAL CATION WITH
FT                   THE HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O +
FT                   UNDETERMINATED METAL CATION(IN) = ADP + PHOSPHATE +
FT                   UNDETERMINATED METAL CATION(OUT)]."
FT                   /EC_number="3.6.3.-"
FT                   /note="Rv3270, (MT3370, MTCY71.10), len: 718 aa. Probable
FT                   ctpC, metal cation-transport ATPase P-type (EC 3.6.3.-),
FT                   integral membrane protein, equivalent to Q9CCL1|CTPC|ML0747
FT                   PUTATIVE CATION TRANSPORT ATPASE from Mycobacterium leprae
FT                   (725 aa), FASTA scores: opt: 3908, E(): 0, (85.95% identity
FT                   in 713 aa overlap). Also similar to O66027|MTAA METAL
FT                   TRANSPORTING ATPASE MTA72 from Mycobacterium tuberculosis
FT                   (680 aa), FASTA scores: opt: 3756, E(): 5.5e-213, (91.45%
FT                   identity in 679 aa overlap); and to other ATPases e.g.
FT                   Q9ZHC7|SILP_SALTY PUTATIVE CATION TRANSPORTING P-TYPE
FT                   ATPASE from Salmonella typhimurium (824 aa), FASTA scores:
FT                   opt: 1145, E(): 1.3e-59, (36.55% identity in 643 aa
FT                   overlap); Q9HX93|PA3920 PROBABLE METAL TRANSPORTING P-TYPE
FT                   ATPASE from Pseudomonas aeruginosa (792 aa), FASTA scores:
FT                   opt: 1140, E(): 2.4e-59, (35.95% identity in 745 aa
FT                   overlap); etc. Contains PS00154 E1-E2 ATPases
FT                   phosphorylation site. BELONGS TO THE CATION TRANSPORT
FT                   ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB."
FT                   /db_xref="GOA:P0A502"
FT                   /db_xref="InterPro:IPR005834"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A502"
FT                   /protein_id="CAB07083.1"
FT                   /translation="MTLEVVSDAAGRMRVKVDWVRCDSRRAVAVEEAVAKQNGVRVVHA
FT                   YPRTGSVVVWYSPRRADRAAVLAAIKGAAHVAAELIPARAPHSAEIRNTDVLRMVIGGV
FT                   ALALLGVRRYVFARPPLLGTTGRTVATGVTIFTGYPFLRGALRSLRSGKAGTDALVSAA
FT                   TVASLILRENVVALTVLWLLNIGEYLQDLTLRRTRRAISELLRGNQDTAWVRLTDPSAG
FT                   SDAATEIQVPIDTVQIGDEVVVHEHVAIPVDGEVVDGEAIVNQSAITGENLPVSVVVGT
FT                   RVHAGSVVVRGRVVVRAHAVGNQTTIGRIISRVEEAQLDRAPIQTVGENFSRRFVPTSF
FT                   IVSAIALLITGDVRRAMTMLLIACPCAVGLSTPTAISAAIGNGARRGILIKGGSHLEQA
FT                   GRVDAIVFDKTGTLTVGRPVVTNIVAMHKDWEPEQVLAYAASSEIHSRHPLAEAVIRST
FT                   EERRISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLRAEKVRVSKKASEWVDKLRRQ
FT                   AETPLLLAVDGTLVGLISLRDEVRPEAAQVLTKLRANGIRRIVMLTGDHPEIAQVVADE
FT                   LGIDEWRAEVMPEDKLAAVRELQDDGYVVGMVGDGINDAPALAAADIGIAMGLAGTDVA
FT                   VETADVALANDDLHRLLDVGDLGERAVDVIRQNYGMSIAVNAAGLLIGAGGALSPVLAA
FT                   ILHNASSVAVVANSSRLIRYRLDR"
FT   misc_feature    184084..184104
FT                   /note="PS00154 E1-E2 ATPases phosphorylation site"
FT   CDS             complement(185016..185684)
FT                   /transl_table=11
FT                   /locus_tag="Rv3271c"
FT                   /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3271c, (MTCY71.11c), len: 222 aa. Probable
FT                   conserved integral membrane protein, similar to others e.g.
FT                   Q9RD35|SCM1.07c from Streptomyces coelicolor (230 aa),
FT                   FASTA scores: opt: 360, E(): 4.7e-16, (33.85% identity in
FT                   195 aa overlap); Q9X897|SCE2.02c from Streptomyces
FT                   coelicolor (234 aa), FASTA scores: opt: 357, E(): 7.3e-16,
FT                   (33.85% identity in 195 aa overlap); Q9D0E0 2610024A01RIK
FT                   PROTEIN from Mus musculus (Mouse) (288 aa), FASTA scores:
FT                   opt: 191, E(): 3.7e-05, (23.65% identity in 207 aa
FT                   overlap)."
FT                   /db_xref="GOA:P96876"
FT                   /db_xref="InterPro:IPR002524"
FT                   /db_xref="UniProtKB/TrEMBL:P96876"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07084.1"
FT                   /translation="METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLLT
FT                   EGAVGLWQGIAVGSVALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVAVS
FT                   FWLTAPYLVAESIRHLAGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSGATA
FT                   GEGTQNYLCAAQAAAVLLGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGHGCGC
FT                   "
FT   CDS             185785..186969
FT                   /transl_table=11
FT                   /locus_tag="Rv3272"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3272, (MTCY71.12), len: 394 aa. Conserved
FT                   hypothetical protein, similar to various proteins e.g.
FT                   Q9I672|PA0446 HYPOTHETICAL PROTEIN from Pseudomonas
FT                   aeruginosa (407 aa), FASTA scores: opt: 643, E(): 6.8e-32,
FT                   (33.15% identity in 389 aa overlap); Q9RJU8|SCF41.21
FT                   PUTATIVE RACEMASE from Streptomyces coelicolor (403 aa),
FT                   FASTA scores: opt: 541, E(): 1.1e-25, (31.95% identity in
FT                   385 aa overlap); O87838|SC8A6.04c PUTATIVE TRANSFERASE from
FT                   Streptomyces coelicolor (410 aa), FASTA scores: opt: 539,
FT                   E(): 1.5e-25, (29.95% identity in 395 aa overlap);
FT                   Q9I563|PA0882 from Pseudomonas aeruginosa (400 aa), FASTA
FT                   scores: opt: 530, E(): 5.2e-25, (28.8% identity in 396 aa
FT                   overlap); BAB60328|TVG1215416 L-CARNITINE DEHYDRATASE from
FT                   Thermoplasma volcanium (399 aa), FASTA scores: opt: 529,
FT                   E(): 6e-25, (32.9% identity in 383 aa overlap); etc.
FT                   C-terminus is similar to Q49678|U00012_27|B1308_C3_195 from
FT                   Mycobacterium leprae (130 aa) (60.0% identity in 115 aa
FT                   overlap). Also partially similar to MTCY359_7 from M.
FT                   tuberculosis (778 aa) (29.9% identity in 388 aa overlap)."
FT                   /db_xref="GOA:P96877"
FT                   /db_xref="HSSP:1PQY"
FT                   /db_xref="InterPro:IPR003673"
FT                   /db_xref="UniProtKB/TrEMBL:P96877"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07085.1"
FT                   /translation="MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPG
FT                   GEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVLEAFR
FT                   PGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVAAEAGMTTGMPTPE
FT                   GKPQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQANQLMMHL
FT                   NRAASDQPKPEPAPKAKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRP
FT                   DLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVD
FT                   TPLFAENDLTLEVGRGADTITVIRTPARYASFRAVVTDPPPTAGEHNAVFLARP"
FT   CDS             186974..189268
FT                   /transl_table=11
FT                   /locus_tag="Rv3273"
FT                   /product="PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE
FT                   (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)"
FT                   /function="GENERATES CO(2) AND H(2)O FROM H(2)CO(3), AND
FT                   POSSIBLY INVOLVED IN TRANSPORT OF SULFATE ACROSS THE
FT                   MEMBRANE."
FT                   /EC_number="4.2.1.1"
FT                   /note="Rv3273, (MTCY71.13), len: 764 aa. Probable
FT                   transmembrane protein (N-terminal part is hydrophobic) with
FT                   probable carbonic anhydrase activity (in C-terminal part)
FT                   (EC 4.2.1.1). Possibly involved in transport of sulfate.
FT                   Equivalent to Q9CBA3|ML2279 PUTATIVE TRANSMEMBRANE
FT                   TRANSPORT PROTEIN from Mycobacterium leprae (496 aa), FASTA
FT                   scores: opt: 1637, E(): 1.8e-89, (59.15% identity in 487 aa
FT                   overlap). Similar to various proteins (principally sulfate
FT                   transporters) e.g. Q9X927|SCH5.25 PUTATIVE INTEGRAL
FT                   MEMBRANE PROTEIN from Streptomyces coelicolor (830 aa),
FT                   FASTA scores: opt: 1325, E(): 8e-71, (40.85% identity in
FT                   788 aa overlap); Q9I729|PA0103 PROBABLE SULFATE TRANSPORTER
FT                   from Pseudomonas aeruginosa (523 aa), FASTA scores: opt:
FT                   1015, E(): 1.3e-52, (39.95% identity in 488 aa overlap);
FT                   Q9KN88|VCA0077 SULFATE PERMEASE FAMILY PROTEIN from Vibrio
FT                   cholerae (553 aa), FASTA scores: opt: 629, E(): 9.6e-30,
FT                   (30.95% identity in 423 aa overlap); etc. C-terminal part
FT                   (aa 550-764) shows similarity to carbonic anhydrase e.g.
FT                   P27134|CYNT_SYNP7 CARBONIC ANHYDRASE (EC 4.2.1.1) (272 aa),
FT                   FASTA scores: opt: 350, E(): 8.1e-15, (33.8% identity in
FT                   201 aa overlap). Contains PS00704 Prokaryotic-type carbonic
FT                   anhydrases signature 1. SEEMS TO BELONG TO THE SULP
FT                   FAMILY."
FT                   /db_xref="GOA:P96878"
FT                   /db_xref="InterPro:IPR015892"
FT                   /db_xref="UniProtKB/TrEMBL:P96878"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07076.1"
FT                   /translation="MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVA
FT                   LPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELIDELGW
FT                   PMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIALQQIHVLLGGTSH
FT                   SSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGATVLA
FT                   LLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVESLL
FT                   SAVGVDKLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIVRSSANVAAGARTRMST
FT                   ILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNFVIYAITI
FT                   VCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDGTLSFLLLP
FT                   RLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVETSPAKLHHA
FT                   HARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHPHIAGLTDSQD
FT                   PYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVS
FT                   SVVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRSAESAGYPE
FT                   ADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEP
FT                   ADRPVDHESAQ"
FT   misc_feature    188723..188746
FT                   /note="PS00704 Prokaryotic-type carbonic anhydrases
FT                   signature 1"
FT   CDS             complement(189257..190426)
FT                   /transl_table=11
FT                   /gene="fadE25"
FT                   /locus_tag="Rv3274c"
FT                   /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE25"
FT                   /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION
FT                   [CATALYTIC ACTIVITY: ACYL-CoA + ETF = 2,3-DEHYDROACYL-CoA +
FT                   REDUCED ETF]."
FT                   /EC_number="1.3.99.-"
FT                   /note="Rv3274c, (MTCY71.14c), len: 389 aa. Probable fadE25,
FT                   Acyl-CoA Dehydrogenase (EC 1.3.99.-), equivalent to
FT                   P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE
FT                   ACYL-CoA DEHYDROGENASE FADE25 from Mycobacterium leprae
FT                   (389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05%
FT                   identity in 389 aa overlap). Also similar to many e.g.
FT                   Q9RIQ5|FADE FATTY ACID ACYL-CoA DEHYDROGENASE from
FT                   Streptomyces lividans (385 aa), FASTA scores: opt: 1692,
FT                   E(): 4.9e-99, (67.35% identity in 383 aa overlap);
FT                   P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa),
FT                   FASTA scores: opt: 1212, E(): 7.2e-69, (51.85% identity in
FT                   376 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus
FT                   halodurans (380 aa), FASTA scores: opt: 1209, E(): 1.1e-68,
FT                   (51.7% identity in 377 aa overlap); P52042|ACDS_CLOAB|BCD
FT                   from Clostridium acetobutylicum (379 aa), FASTA scores:
FT                   opt: 1056, E(): 4.6e-59, (44.6% identity in 379 aa
FT                   overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases
FT                   signature 1, PS00073 Acyl-CoA dehydrogenases signature 2.
FT                   BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY."
FT                   /db_xref="GOA:P63427"
FT                   /db_xref="HSSP:1JQI"
FT                   /db_xref="InterPro:IPR006091"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63427"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07077.1"
FT                   /translation="MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKA
FT                   RFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVNKLGT
FT                   MGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILNGAK
FT                   CWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELY
FT                   FENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQFG
FT                   ESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFISAASKCFASDVAMEV
FT                   TTDAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR"
FT   misc_feature    complement(189332..189391)
FT                   /note="PS00073 Acyl-CoA dehydrogenases signature 2"
FT   misc_feature    complement(189992..190030)
FT                   /note="PS00072 Acyl-CoA dehydrogenases signature 1"
FT   CDS             complement(190451..190975)
FT                   /transl_table=11
FT                   /gene="purE"
FT                   /locus_tag="Rv3275c"
FT                   /product="PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE
FT                   CATALYTIC SUBUNIT PURE (AIR CARBOXYLASE) (AIRC)"
FT                   /function="INVOLVED IN PURINE BIOSYNTHESIS (SIXTH STEP).
FT                   THIS SUBUNIT CAN ALONE TRANSFORM AIR TO CAIR, BUT IN
FT                   ASSOCIATION WITH PURK, WHICH POSSESSES AN ATPASE ACTIVITY,
FT                   AN ENZYME COMPLEX IS PRODUCED WHICH IS CAPABLE OF
FT                   CONVERTING AIR TO CAIR EFFICIENTLY UNDER PHYSIOLOGICAL
FT                   CONDITION [CATALYTIC ACTIVITY:
FT                   1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE-CARBOXYLATE =
FT                   1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2)]."
FT                   /EC_number="4.1.1.21"
FT                   /note="Rv3275c, (MTCY71.15c, PUR6), len: 174 aa. Probable
FT                   purE, phosphoribosylaminoimidazole carboxylase catalytic
FT                   subunit (EC 4.1.1.21), equivalent to
FT                   P46702|PUR6_MYCLE|PURE|ML0736|B1308_F3_98 from
FT                   Mycobacterium leprae (171 aa), FASTA scores: opt: 878, E():
FT                   1.5e-43, (81.55% identity in 168 aa overlap). Also similar
FT                   to others e.g. Q9AXD0|AIRC from Nicotiana tabacum (Common
FT                   tobacco) (623 aa), FASTA scores: opt: 712, E(): 1.4e-33,
FT                   (69.35% identity in 160 aa overlap) (similarity in
FT                   C-terminal part for this one); Q44679|PUR6_CORAM from
FT                   Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
FT                   (177 aa), FASTA scores: opt: 651, E(): 1.5e-30, (68.25%
FT                   identity in 148 aa overlap); Q55498|PUR6_SYNY3|PURE|SLL0901
FT                   from Synechocystis sp. strain PCC 6803 (176 aa), FASTA
FT                   scores: opt: 639, E(): 7.1e-30, (60.5% identity in 167 aa
FT                   overlap); etc."
FT                   /db_xref="GOA:P96880"
FT                   /db_xref="HSSP:1O4V"
FT                   /db_xref="InterPro:IPR000031"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96880"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07078.1"
FT                   /translation="MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAH
FT                   RTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLDSL
FT                   LSIVQMPAGVPVATVSIGGAGNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKDAE
FT                   LQRLAGKLTRD"
FT   CDS             complement(190972..192261)
FT                   /transl_table=11
FT                   /gene="purK"
FT                   /locus_tag="Rv3276c"
FT                   /product="PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE
FT                   ATPASE SUBUNIT PURK (AIR CARBOXYLASE) (AIRC)"
FT                   /function="INVOLVED IN PURINE BIOSYNTHESIS (SIXTH STEP).
FT                   POSSESSES AN ATPASE ACTIVITY THAT IS DEPENDENT ON THE
FT                   PRESENCE OF AIR (AMINOIMIDAZOLE RIBONUCLEOTIDE). THE
FT                   ASSOCIATION OF PURK AND PURE PRODUCES AN ENZYME COMPLEX
FT                   CAPABLE OF CONVERTING AIR TO CAIR EFFICIENTLY UNDER
FT                   PHYSIOLOGICAL CONDITION [CATALYTIC ACTIVITY:
FT                   1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE-CARBOXYLATE =
FT                   1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2)]."
FT                   /EC_number="4.1.1.21"
FT                   /note="Rv3276c, (MTCY71.16c), len: 429 aa. Probable purK,
FT                   phosphoribosylaminoimidazole carboxylase ATPase subunit (EC
FT                   4.1.1.21), equivalent to
FT                   P46701|PURK_MYCLE|ML0735|B1308_F1_32
FT                   PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT
FT                   from Mycobacterium leprae (439 aa), FASTA scores: opt:
FT                   2168, E(): 2.3e-123, (76.15% identity in 444 aa overlap).
FT                   Also similar to others e.g. Q44678|PURK_CORAM from
FT                   Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
FT                   (413 aa), FASTA scores: opt: 1179, E(): 9.1e-64, (48.35%
FT                   identity in 389 aa overlap); Q9KZ85|PURK from Streptomyces
FT                   coelicolor (368 aa), FASTA scores: opt: 1150, E(): 4.7e-62,
FT                   (55.35% identity in 345 aa overlap); Q54975|PURK_SYNP7 from
FT                   Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
FT                   (395 aa), FASTA scores: opt: 772, E(): 3e-39, (38.1%
FT                   identity in 383 aa overlap); etc. BELONGS TO THE PURK /
FT                   PURT FAMILY."
FT                   /db_xref="GOA:P65898"
FT                   /db_xref="HSSP:1B6R"
FT                   /db_xref="InterPro:IPR013817"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65898"
FT                   /protein_id="CAB07079.1"
FT                   /translation="MMAVASSRTPAVTSFIAPLVAMVGGGQLARMTHQAAIALGQNLRV
FT                   LVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGADVLTFDHEHVPNELLEKLVADGVNV
FT                   APSPQALVHAQDKLVMRQRLAAAGVAVPRYAGIKDPDEIDVFAARVDAPIVVKAVRGGY
FT                   DGRGVRMARDVADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAWPVVQ
FT                   TVQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETTDGALLVNE
FT                   LAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPVTVMANVLGAAQPPAMSV
FT                   DERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGSDVAQLCERAELAAHWLSHGRWT
FT                   DGWDPHRASDDAVGVPPACGGRSDEEERRL"
FT   repeat_region   complement(190995..191052)
FT                   /note="58 bp Mycobacterial Interspersed Repetitive Unit,
FT                   Class III"
FT   CDS             192215..193033
FT                   /transl_table=11
FT                   /locus_tag="Rv3277"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3277, (MTCY71.17), len: 272 aa. Probable conserved
FT                   transmembrane protein, equivalent, but longer 49 aa, to
FT                   Q49673|B1308_C1_121|ML0734 PUTATIVE MEMBRANE PROTEIN from
FT                   Mycobacterium leprae (228 aa), FASTA scores: opt: 1266,
FT                   E(): 6.1e-78, (84.2% identity in 228 aa overlap). Also
FT                   similar to various proteins (principally unknowns) e.g.
FT                   Q9KZ84|SCE25.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from
FT                   Streptomyces coelicolor (190 aa), FASTA scores: opt: 197,
FT                   E(): 3.6e-06, (32.0% identity in 150 aa overlap);
FT                   BAB50058|MLL3086 HYPOTHETICAL PROTEIN from Rhizobium loti
FT                   (Mesorhizobium loti) (136 aa), FASTA scores: opt: 176, E():
FT                   6.9e-05, (34.7% identity in 147 aa overlap); O29640|AF0615
FT                   HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (129 aa),
FT                   FASTA scores: opt: 120, E(): 0.38, (23.35% identity in 120
FT                   aa overlap); Q9KJU8|GTCA TEICHOIC ACID GLYCOSYLATION
FT                   PROTEIN from Listeria innocua (145 aa), FASTA scores: opt:
FT                   117, E(): 0.67, (23.85% identity in 151 aa overlap); etc.
FT                   Equivalent to AAK47718 from Mycobacterium tuberculosis
FT                   strain CDC1551 (256 aa) but longer 16 aa. Contains PS00044
FT                   Bacterial regulatory proteins, lysR family signature."
FT                   /db_xref="GOA:P96882"
FT                   /db_xref="InterPro:IPR007267"
FT                   /db_xref="UniProtKB/TrEMBL:P96882"
FT                   /protein_id="CAB07080.1"
FT                   /translation="MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSSV
FT                   HSLVVSFADATIARLPGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEPKP
FT                   VTAKVIAGIVAVIASYVLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWFSSY
FT                   ILQLRVPTVSLTMENIADFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKALESAL
FT                   TAGGIAEVFEDVLEGGFEDGNVTLLRAWRNRANRFAQLGDSSEPRVSKTS"
FT   misc_feature    192650..192727
FT                   /note="PS00044 Bacterial regulatory proteins, lysR family
FT                   signature"
FT   CDS             complement(192988..193506)
FT                   /transl_table=11
FT                   /locus_tag="Rv3278c"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv3278c, (MTCY71.18c), len: 172 aa. Probable
FT                   conserved transmembrane protein, equivalent to
FT                   Q9CCL2|ML0733 PUTATIVE MEMBRANE PROTEIN from Mycobacterium
FT                   leprae (172 aa), FASTA scores: opt: 1024, E(): 6e-61,
FT                   (83.15% identity in 172 aa overlap); and Q49672|B1308_F2_67
FT                   HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa),
FT                   FASTA scores: opt: 1024, E(): 6.3e-61, (83.15% identity in
FT                   172 aa overlap) (this is certainly the same putative
FT                   protein but with N-terminus longer). Also some similarity
FT                   to other hypothetical proteins (generally membrane
FT                   proteins) e.g. O26822|MTH726 HYPOTHETICAL PROTEIN from
FT                   Methanobacterium thermoautotrophicum (204 aa), FASTA
FT                   scores: opt: 147, E(): 0.0079, (24.6% identity in 187 aa
FT                   overlap); Q9X8H4|SCE9.01 HYPOTHETICAL 47.7 KDA PROTEIN
FT                   (FRAGMENT) from Streptomyces coelicolor (436 aa), FASTA
FT                   scores: opt: 151, E(): 0.0079, (28.1% identity in 153 aa
FT                   overlap)."
FT                   /db_xref="GOA:P96883"
FT                   /db_xref="InterPro:IPR005182"
FT                   /db_xref="UniProtKB/TrEMBL:P96883"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07081.1"
FT                   /translation="MSYPENVLAAGEQVVLHRHPHWNRLIWPVVVLVLLTGLAAFGSGF
FT                   VNSTPWQQIAKNVIHAVIWGIWLVIVGWLTLWPFLSWLTTHFVVTNRRVMFRHGVLTRS
FT                   GIDIPLARINSVEFRDRIFERIFRTGTLIIESASQDPLEFYNIPRLREVHALLYHEVFD
FT                   TLGSDESPS"
FT   CDS             complement(193549..194349)
FT                   /transl_table=11
FT                   /gene="birA"
FT                   /locus_tag="Rv3279c"
FT                   /product="POSSIBLE BIFUNCTIONAL PROTEIN BIRA: BIOTIN OPERON
FT                   REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE
FT                   (BIOTIN--PROTEIN LIGASE)"
FT                   /function="BIRA ACTS BOTH AS A BIOTIN-OPERON REPRESSOR AND
FT                   AS THE ENZYME THAT SYNTHESIZES THE COREPRESSOR,
FT                   ACETYL-COA:CARBON-DIOXIDE LIGASE. THIS PROTEIN ALSO
FT                   ACTIVATES BIOTIN TO FORM BIOTINYL-5'-ADENYLATE AND
FT                   TRANSFERS THE BIOTIN MOIETY TO BIOTIN-ACCEPTING PROTEINS
FT                   [CATALYTIC ACTIVITY: ATP + BIOTIN +
FT                   APO-[ACETYL-COA:CARBON-DIOXIDE LIGASE (ADP FORMING)] = AMP
FT                   + PYROPHOSPHATE + [ACETYL-COA:CARBON-DIOXIDE LIGASE (ADP
FT                   FORMING)]]."
FT                   /EC_number="6.3.4.15"
FT                   /note="Rv3279c, (MTCY71.19c), len: 266 aa. Possible birA,
FT                   bifunctional protein: biotin operon repressor and
FT                   biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15),
FT                   equivalent to Q9CCL3|BIRA|ML0732 BIOTIN APO-PROTEIN LIGASE
FT                   from Mycobacterium leprae (274 aa), FASTA scores: opt:
FT                   1189, E(): 2.3e-66, (71.2% identity in 271 aa overlap). But
FT                   as it lacks a BirA h-t-h domain at N-terminus, may simply
FT                   be biotin apo-protein ligase. Also similar to others e.g.
FT                   Q9CNX6|BIRA|PM0296 from Past