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EBI DbfetchID BX842581; SV 1; linear; genomic DNA; STD; PRO; 348676 BP. XX AC BX842581; AL008883; AL008967; AL021070; AL021287; AL021309; Z74024; Z74697; AC Z81331; Z83018; Z83857-Z83858; Z83866; Z95150; Z95207; XX DT 21-NOV-2003 (Rel. 77, Created) DT 14-JUL-2009 (Rel. 101, Last updated, Version 6) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 10/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-348676 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF00005; tRNA. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..348676 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT repeat_region complement(148..183) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(148..4539) FT /note="4392 bp direct repeat region" FT repeat_region complement(222..257) FT /note="36 bp direct repeat, 35 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(298..333) FT /note="36 bp direct repeat, 35 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(374..409) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(447..482) FT /note="36 bp direct repeat, 35 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(519..554) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(590..625) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(664..699) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(740..775) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(811..846) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(884..919) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(958..993) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(1031..1066) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(1104..1139) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(1176..1211) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(1248..1283) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(1322..1357) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(1396..1431) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(1467..1486) FT /note="20 bp partial direct repeat, CCCCGAGAGGGGACGGAAAC, FT of sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(1486..2860) FT /mobile_element="insertion sequence:IS6110-11" FT /note="IS6110-11, len: 1375 bp. Insertion sequence IS6110." FT CDS complement(1529..>2467) FT /transl_table=11 FT /locus_tag="Rv2814c" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2814c, (MTCY16B7.29), len: 312 aa. Probable FT transposase, highly similar to others e.g. FT P97137|Rv0796|MTV042.06 PUTATIVE TRANSPOSASE FOR INSERTION FT SEQUENCE ELEMENT IS986/IS6110 from Mycobacterium FT tuberculosis (328 aa), FASTA scores: opt: 2103, E(): FT 6.1e-132, (100.0% identity in 312 aa overlap); etc. Start FT unlikely." FT /db_xref="GOA:P0C5G8" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8" FT /protein_id="CAB03675.1" FT /translation="LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYDH FT INREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLG FT LSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVT FT DAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFS FT ERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWF FT NHRRLYQYCGDVPPVELEAAYYAQRQRPAAG" FT CDS complement(2464..2790) FT /transl_table=11 FT /locus_tag="Rv2815c" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2815c, (MTCY16B7.28), len: 108 aa. Probable FT transposase, identical from aa 51 with P19772|YIA2_MYCTU FT PUTATIVE TRANSPOSASE (INSERTION ELEMENT IS986) from FT Mycobacterium tuberculosis (59 aa), FASTA scores: opt: 365, FT E(): 1.1e-19, (96.6% identity in 59 aa overlap); and other FT transposases." FT /db_xref="GOA:P0C5G9" FT /db_xref="InterPro:IPR002514" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9" FT /protein_id="CAB03633.1" FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD FT RPAR" FT repeat_region complement(2845..2860) FT /note="16 bp partial direct repeat, GTCGTCAGACCCAAAA, of FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(2901..2936) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(2976..3011) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3049..3084) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3121..3156) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3193..3228) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3266..3301) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3338..3373) FT /note="36 bp direct repeat, 32 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3399..3434) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3476..3511) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3548..3583) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3624..3659) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3701..3736) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3774..3809) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3845..3880) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3918..3953) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(3992..4027) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(4065..4100) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(4136..4171) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(4211..4246) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(4281..4316) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(4353..4388) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(4430..4465) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT repeat_region complement(4504..4539) FT /note="36 bp direct repeat, 36 out of 36 bp identical to FT sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC" FT CDS complement(4588..4929) FT /transl_table=11 FT /locus_tag="Rv2816c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2816c, (MTCY16B7.27), len: 113 aa. Conserved FT hypothetical protein, highly similar in part to N-terminus FT of several proteins e.g. O28403|AF1876 CONSERVED FT HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (94 aa), FT FASTA scores: opt: 137, E(): 0.0022, (47.55% identity in 61 FT aa overlap); Q97Y85|SSO8090 HYPOTHETICAL PROTEIN from FT Sulfolobus solfataricus (88 aa), FASTA scores: opt: 124, FT E(): 0.02, (37.3% identity in 59 aa overlap); etc." FT /db_xref="InterPro:IPR003799" FT /db_xref="UniProtKB/TrEMBL:P71637" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB03632.1" FT /translation="MPTRSREEYFNLPLKVDESSGTIGKMFVLVIYDISDNRRRASLAK FT ILAGFGYRVQESAFEAMLTKGQLAKLVARIDRFAIDCDNIRIYKIRGVAAVTFYGRGRL FT VSAEEFVFF" FT CDS complement(4930..5946) FT /transl_table=11 FT /locus_tag="Rv2817c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2817c, (MTCY16B7.26), len: 338 aa. Conserved FT hypothetical protein, showing similarity with O30236|AF2435 FT CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus FT (322 aa), FASTA scores: opt: 397, E(): 2.4e-19, (28.2% FT identity in 298 aa overlap); Q9KFX9|BH0341 HYPOTHETICAL FT PROTEIN from Bacillus halodurans (343 aa), FASTA scores: FT opt: 337, E(): 2.8e-15, (27.35% identity in 300 aa FT overlap); Q9X2B7|TM1797 CONSERVED HYPOTHETICAL PROTEIN from FT Thermotoga maritima (319 aa), FASTA scores: opt: 321, E(): FT 3.3e-14, (26.5% identity in 268 aa overlap); etc." FT /db_xref="InterPro:IPR002729" FT /db_xref="UniProtKB/TrEMBL:P71636" FT /protein_id="CAB03631.1" FT /translation="MVQLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGR FT PTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPDVSYAPRLRQQVHRTDDPAFCLSLS FT KRIVSRKILNQQALIRAHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAKAYF FT TALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQD FT SRGHATLASDLMEVWRAPIIDDTVLRLIADGVVDTRAFSKNSDTGAVFATREATRSIAR FT AFGNRIARTATYIKGDPHRYTFQYALDLQLQSLVRVIEAGHPSRLVDIDITSEPSGA" FT CDS complement(5959..7107) FT /transl_table=11 FT /locus_tag="Rv2818c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2818c, (MTCY16B7.25), len: 382 aa. Hypothetical FT unknown protein, equivalent to AAK47210 from Mycobacterium FT tuberculosis strain CDC1551 (430 aa) but shorter 48 aa." FT /db_xref="InterPro:IPR013489" FT /db_xref="UniProtKB/TrEMBL:P71635" FT /protein_id="CAB03668.1" FT /translation="MLFLSAEIAAFENADRRYSAAITRLAPETDVRIVTYTNPSVHRFD FT LFVPVFRNHLVELSAEFPDRTILLNTSSGTPAMQAALVAINVFGIPRTTAVQVSTPARA FT LSKPGDRESPDAYDLELMWDANDDNQPGAPNRCFEATSAALGALLERANLKQLIVSYDY FT SAAVTIAADSRLPDQVSNLIRGAMHRSRLEHLVAPKFFKDTAFTYDPANKVAEYISALA FT LLAKREQWAEFARSATPAITIVLRAAVAKHLPEDRYLDDMGRVDRRKLEREPEIRCALK FT HPPKSPNAEWYLYTKDWLALLRQFAPDRVGALEVLGRFESRVRNTAAHEIVSISEDRIT FT KDGGLLPEQLLKILARETGADLTLYDRLNDEIIRQIDMAPLG" FT CDS complement(7203..8330) FT /transl_table=11 FT /locus_tag="Rv2819c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2819c, (MTCY16B7.23), len: 375 aa. Hypothetical FT unknown protein (see citations below)." FT /db_xref="InterPro:IPR010173" FT /db_xref="UniProtKB/TrEMBL:P71633" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB03667.1" FT /translation="MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDMEL FT LYADIPAHKRKSFEAFVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEPRR FT ASRGRGGRMTRKKLTLNEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQPVR FT VPGHQTREHRQYGERFERKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDLLICQ FT KMDMNVHGKPDGLPLFRECLAPGTSISHRVVVDTSPTARGGWREGERFLETLAETAASV FT NQARYAEYRAMYPGVNAIVGPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGKVVKHVD FT KTRELRVSPLVLKRTKIDNICYEMGQCELSIRRAE" FT CDS complement(8327..9235) FT /transl_table=11 FT /locus_tag="Rv2820c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2820c, (MTCY16B7.22), len: 302 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR005537" FT /db_xref="UniProtKB/TrEMBL:P71632" FT /protein_id="CAB03666.1" FT /translation="MNSRLFRFDFDRTHFGDHGLESSTISCPADTLYSALCVEALRMGG FT QQLLGELVACSTLRLTDLLPYVGPDYLVPKPLHSVRSDGSSMQKKLAKKIGFLPAAQLG FT SFLDGTADLKELAARQTKIGVHAVSAKAAIHNGKKDADPYRVGYFRFELDAGLWLLATG FT SESELGLLTRLLKGISALGGERTSGFGAFNLTESEAPAALTPTVDAASLMTLTTSLPTD FT DELEAALAGATYRLVKRSGFVASSTYADMPLRKRDIYKFAAGSVFSRPFQGGILDVSLG FT GNHPVYSYARPLFLALPESAA" FT CDS complement(9216..9926) FT /transl_table=11 FT /locus_tag="Rv2821c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2821c, (MTCY16B7.21), len: 236 aa. Conserved FT hypothetical protein, similar to several hypothetical FT proteins e.g. Q9X2C9|TM1809 CONSERVED HYPOTHETICAL PROTEIN FT from Thermotoga maritima (247 aa), FASTA scores: opt: 318, FT E(): 8.2e-15, (39.45% identity in 213 aa overlap); FT O27152|MTH1080 CONSERVED HYPOTHETICAL PROTEIN from FT Methanothermobacter thermautotrophicus (245 aa), FASTA FT scores: opt: 294, E(): 3.9e-13, (34.8% identity in 224 aa FT overlap); BAB59251|TVG0114661 HYPOTHETICAL PROTEIN from FT Thermoplasma volcanium (229 aa), FASTA scores: opt: 252, FT E(): 3.3e-10, (33.8% identity in 225 aa overlap); etc." FT /db_xref="InterPro:IPR013412" FT /db_xref="UniProtKB/TrEMBL:P71631" FT /protein_id="CAB03665.1" FT /translation="MTTSYAKIEITGTLTVLTGLQIGAGDGFSAIGAVDKPVVRDPLSR FT LPMIPGTSLKGKVRTLLSRQYGADTETFYRKPNEDHAHIRRLFGDTEEYMTGRLVFRDT FT KLTNKDDLEARGAKTLTEVKFENAINRVTAKANLRQMERVIPGSEFAFSLVYEVSFGTP FT GEEQKASLPSSDEIIEDFNAIARGLKLLELDYLGGSGTRGYGQVKFSNLKARAAVGALD FT GSLLEKLNHELAAV" FT CDS complement(9936..10310) FT /transl_table=11 FT /locus_tag="Rv2822c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2822c, (MTCY16B7.20), len: 124 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR010149" FT /db_xref="UniProtKB/TrEMBL:P71630" FT /protein_id="CAB03664.1" FT /translation="MSVIQDDYVKQAEVIRGLPKKKNGFELTTTQLRVLLSLTAQLFDE FT AQQSANPTLPRQLKEKVQYLRVRFVYQSGREDAVKTFVRNAKLLEALEGIGDSRDGLLR FT FCRYMEALAAYKKYLDPKDK" FT CDS complement(10307..12736) FT /transl_table=11 FT /locus_tag="Rv2823c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2823c, (MTCY16B7.19), len: 809 aa. Conserved FT hypothetical protein, similar in part to others e.g. FT Q9X2D1|TM1811Thermotoga maritima (717 aa), FASTA scores: FT opt: 401, E(): 3.6e-18, (27.15% identity in 773 aa FT overlap); O27154|MTH1082 CONSERVED HYPOTHETICAL PROTEIN FT from Methanothermobacter thermautotrophicus (822 aa), FASTA FT scores: opt: 306, E(): 6e-12, (25.55% identity in 872 aa FT overlap); Q59066|MJ1672 HYPOTHETICAL PROTEIN from FT Methanococcus jannaschii (800 aa), FASTA scores: opt: 302, FT E(): 1.1e-11, (24.9% identity in 812 aa overlap); etc." FT /db_xref="InterPro:IPR000160" FT /db_xref="UniProtKB/TrEMBL:P71629" FT /protein_id="CAB03663.1" FT /translation="MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWL FT RDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYNIA FT AGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPSPRR FT IEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFD FT HLKLTGALGACIWHYLQATGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIH FT SSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNYSGGGHAYLLLPNTESARKSV FT EQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELS FT EQLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTA FT ASSQIQSESRRFLLISDGATKGLPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFA FT GECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLGQAFTHGFMEQGNGKFN FT TISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVVGAW FT DDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNG FT VALFDREFTFGWDELLSKVIEEKYRHIADYFSGNEERGMAFIYKLLELLAERDDRITKA FT RWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHLYIYRTRKEESE" FT CDS complement(12733..13677) FT /transl_table=11 FT /locus_tag="Rv2824c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2824c, (MTCY16B7.18), len: 314 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR019267" FT /db_xref="UniProtKB/TrEMBL:P71628" FT /protein_id="CAB03662.1" FT /translation="MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGF FT SHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGPHLHGVLMESIPADYVQTLHTVPVN FT PYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRSLEQ FT NPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGE FT EPDPGLIAEFGQSVRLSAFRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLW FT FGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP" FT CDS complement(13855..14502) FT /transl_table=11 FT /locus_tag="Rv2825c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2825c, (MTCY16B7.17), len: 215 aa. Conserved FT hypothetical protein, similar to Q9RY53|DR0097 CONSERVED FT HYPOTHETICAL PROTEIN from Deinococcus radiodurans (189 aa), FT FASTA scores: opt: 261, E(): 8e-11, (33.5% identity in 176 FT aa overlap); and shows some similarity with N-terminus of FT O27278|MTH1210 MRR RESTRICTION SYSTEM RELATED PROTEIN from FT Methanothermobacter thermautotrophicus (340 aa), FASTA FT scores: opt: 133, E(): 0.091, (28.55% identity in 112 aa FT overlap). Equivalent to AAK47217 from Mycobacterium FT tuberculosis strain CDC1551 (246 aa) but shorter 31 aa; and FT equivalent to upstream ORF P71624|Rv2828c|MTCY16B7.14 from FT Mycobacterium tuberculosis strain H37Rv (alias AAK47221 FT from strain CDC1551) (181 aa), FASTA scores: opt: 1169, FT E(): 8.5e-74, (98.35% identity in 181 aa overlap)." FT /db_xref="InterPro:IPR008307" FT /db_xref="UniProtKB/TrEMBL:P71627" FT /protein_id="CAB03661.1" FT /translation="MKLPGAKRLGDDRRPLGTLRCWRHSDIGPARGIVVTPALKEWSAA FT VHALLDGRQTVLLRKGGIGEKRFEVAAHEFLLFPTVAHSHAERVRPEHRDLLGPAAADS FT TDECVLLRAAAKVVAALPVNRPEGLDAIEDLHIWTAESVRADRLDFRPKHKLAVLVVSA FT IPLAEPVRLARRPEYGGCTSWVQLPVTPTLAAPVHDEAALAEVAARVREAVG" FT CDS complement(14672..15556) FT /transl_table=11 FT /locus_tag="Rv2826c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2826c, (MTCY16B7.16), len: 294 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR014942" FT /db_xref="UniProtKB/TrEMBL:P71626" FT /protein_id="CAB03660.1" FT /translation="MAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDN FT RLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVVLEVCELIDGARVGGFEFGVQSTRG FT DGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLPVVA FT EAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPL FT RVEDVLAARSEHDFQPDSIGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERH FT RREVENALAVLRS" FT CDS complement(15559..16446) FT /transl_table=11 FT /locus_tag="Rv2827c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2827c, (MTCY16B7.15), len: 295 aa. Hypothetical FT unknown protein, equivalent to AAK47219 from Mycobacterium FT tuberculosis strain CDC1551 (315 aa) but shorter 20 aa." FT /db_xref="InterPro:IPR018547" FT /db_xref="UniProtKB/TrEMBL:P71625" FT /protein_id="CAB03659.1" FT /translation="MVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCG FT RDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGA FT SAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVR FT RRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSG FT RPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLV FT DELVVPLLRVIGKA" FT CDS complement(16751..17296) FT /transl_table=11 FT /locus_tag="Rv2828c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2828c, (MTCY16B7.14), len: 181 aa. Conserved FT hypothetical protein, similar to Q9RY53|DR0097 CONSERVED FT HYPOTHETICAL PROTEIN from Deinococcus radiodurans (189 aa), FT FASTA scores: opt: 267, E(): 1.9e-11, (34.1% identity in FT 176 aa overlap); and shows some similarity with N-terminus FT of O27278|MTH1210 MRR RESTRICTION SYSTEM RELATED PROTEIN FT from Methanothermobacter thermautotrophicus (340 aa), FASTA FT scores: opt: 133, E(): 0.07, (28.55% identity in 112 aa FT overlap). Also equivalent to downstream ORF FT P71627|Rv2825c|MTCY16B7.17 from Mycobacterium tuberculosis FT strain H37Rv (alias AAK47217 from strain CDC1551, 246 aa) FT (215 aa), FASTA scores: opt: 1173, E(): 8.3e-75, (98.9% FT identity in 181 aa overlap)." FT /db_xref="InterPro:IPR014923" FT /db_xref="UniProtKB/TrEMBL:P71624" FT /protein_id="CAB03658.1" FT /translation="MTPALKEWSAAVHALLDGRQTVLLRKGGIGEKRFEVAAHEFLLFP FT TVAHSHAERVRPEHRDLLGPAAADSTDECVLLRAAAKVVAALPVNRPEGLDAIEDLHIW FT TAESVRADRLDFRPKHRLAVLVVSAIPLAEPVRLARTPEYGGCTSWVQLPVTPTLAAPV FT HDEAALAEVAARVREAVG" FT CDS complement(17583..17975) FT /transl_table=11 FT /locus_tag="Rv2829c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2829c, (MTCY16B7.13), len: 130 aa. Conserved FT hypothetical protein similar to AAK65872|SMA2253 CONSERVED FT HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium FT meliloti) (125 aa), FASTA scores: opt: 171, E(): 7.7e-05, FT (34.9% identity in 129 aa overlap); and shows some FT similarity with other proteins e.g. Q9AH69 HYPOTHETICAL FT 14.7 KDA PROTEIN from Neisseria meningitidis (128 aa), FT FASTA scores: opt: 148, E(): 0.0031, (28.1% identity in 121 FT aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:P71623" FT /protein_id="CAB03657.1" FT /translation="MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFEL FT AWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSVAATAVALPSSFPGDPADRLIYATA FT IEHGWRLVTKDRRLRSHRHPRPVTVW" FT CDS complement(17972..18187) FT /transl_table=11 FT /locus_tag="Rv2830c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2830c, (MTCY16B7.12), len: 71 aa. Hypothetical FT protein, some similarity to Z97182|MTCY19H5.26|Rv0596c FT Hypothetical protein from Mycobacterium tuberculosis (85 FT aa), FASTA scores: opt: 88, E(): 1.3, (41.7% identity in 36 FT aa overlap); and to PHD_BPP1|Q06253 bacteriophage P1 phd FT gene (73 aa), FASTA scores: opt: 79, E(): 3.8, (35.9% FT identity in 39 aa overlap)." FT /db_xref="InterPro:IPR006442" FT /db_xref="UniProtKB/TrEMBL:P71622" FT /protein_id="CAB03656.1" FT /translation="MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALK FT GRFSGVAMAAADDDELFTTGVSWNVS" FT CDS 18234..18983 FT /transl_table=11 FT /gene="echA16" FT /locus_tag="Rv2831" FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA16 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv2831, (MTCY16B7.11c), len: 249 aa. Probable FT echA16, enoyl-CoA hydratase (EC 4.2.1.17), similar to FT others e.g. O23468|AT4G16210 from Arabidopsis thaliana FT (Mouse-ear cress) (244 aa), FASTA scores: opt: 491, E(): FT 7.3e-25, (42.1% identity in 190 aa overlap); Q98LI4|MLL1009 FT from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA FT scores: opt: 491, E(): 7.6e-25, (40.75% identity in 248 aa FT overlap); O07137|ECH8_MYCLE|ML2402|MLCB1306.05c from FT Mycobacterium leprae (257 aa), FASTA scores: opt: 478, E(): FT 5.3e-24, (38.05% identity in 226 aa overlap); FT P76082|PAAF_ECOLI|B1393 from scherichia coli strain K12 FT (255 aa), FASTA scores: opt: 439, E(): 1.9e-21, (37.55% FT identity in 221 aa overlap); etc. Also similar to FT O53418|ECH8_MYCTU|ECHA8|Rv1070c|MT1100|MTV017.23c from FT Mycobacterium tuberculosis (257 aa), FASTA scores: opt: FT 471, E(): 1.5e-23, (38.05% identity in 226 aa overlap)." FT /db_xref="GOA:P71621" FT /db_xref="HSSP:1MJ3" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:P71621" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB03655.1" FT /translation="MTDDILLIDTDERVRTLTLNRPQSRNALSAALRDRFFAALADAEA FT DDDIDVVILTGADPVFCAGLDLKELAGQTALPDISPRWPAMTKPVIGAINGAAVTGGLE FT LALYCDILIASEHARFADTHARVGLLPTWGLSVRLPQKVGIGLARRMSLTGDYLSATDA FT LRAGLVTEVVAHDQLLPTARRVAASIVGNNQNAVRALLASYHRIDESQTAAGLWLEACA FT AKQFRTSGDTIAANREAVLQRGRAQVR" FT CDS complement(19062..20144) FT /transl_table=11 FT /gene="ugpC" FT /locus_tag="Rv2832c" FT /product="PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT FT ATP-BINDING PROTEIN ABC TRANSPORTER UGPC" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT Sn-GLYCEROL-3-PHOSPHATE ACROSS THE MEMBRANE (IMPORT). FT RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM." FT /note="Rv2832c, (MTCY16B7.10), len: 360 aa. Probable ugpC, FT Sn-glycerol-3-phosphate transport ATP-binding protein ABC FT transporter (see Braibant et al., 2000), similar to others: FT CAC48805 PROBABLE GLYCEROL-3-PHOSPHATE ABC TRANSPORTER FT ATP-BINDING PROTEIN from Rhizobium meliloti (Sinorhizobium FT meliloti) plasmid pSymB (349 aa), FASTA scores: opt: 1018, FT E(): 4.1e-53, (48.6% identity in 356 aa overlap); FT Q98G42|MLL3499|UGPC SN-GLYCEROL-3-PHOSPHATE TRANSPORT FT ATP-BINDING PROTEIN from Rhizobium loti (Mesorhizobium FT loti) (366 aa), FASTA scores: opt: 1016, E(): 5.6e-53, FT (48.5% identity in 367 aa overlap). But also highly similar FT to many msiK proteins, ABC transporter ATP-binding proteins FT possibly involved in transport of cellolbiose and maltose FT (see Schlosser et al., 1997) e.g. P96483|MSIK MSIK PROTEIN FT from Streptomyces reticuli (377 aa), FASTA scores: opt: FT 1277, E(): 1.9e-68, (58.05% identity in 379 aa overlap); FT Q9L0Q1|MSIK ABC TRANSPORTER ATP-BINDING PROTEIN from FT Streptomyces coelicolor (378 aa), FASTA scores: opt: 1276, FT E(): 2.1e-68, (57.65% identity in 380 aa overlap); FT Q54333|MSIK from Streptomyces lividans (314 aa), FASTA FT scores: opt: 1217, E(): 5.9e-65, (63.7% identity in 292 aa FT overlap); and other ABC-TYPE SUGAR TRANSPORT PROTEINS. Also FT highly similar to O53482|Rv2038c|MTV018.25c ABC-TYPE SUGAR FT TRANSPORT PROTEIN from Mycobacterium tuberculosis (357 aa), FT FASTA scores: opt: 1248, E(): 9.4e-67, (56.8% identity in FT 354 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop), and PS00211 ABC transporters family FT signature. BELONG TO THE ATP-BINDING TRANSPORT PROTEIN FT FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:P71620" FT /db_xref="HSSP:1G29" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:P71620" FT /protein_id="CAB03654.1" FT /translation="MANVQYSAVTQRYPGADAPTVDNLDLDIADGEFLVLVGPSGCGKS FT TTLRVLAGLEPIESGRISIGDVDVTHLPPRARDVAMVFQNYALYPNMTVAANMGFALRN FT AGMSRADTRRRVLEVADMLELTDLLDRKPAKLSGGQRQRVAMGRAIVRRPRVFCMDEPL FT SNLDAKLRVSTRSQISGLQRRLGTTTVYVTHDQVEAMTMGDRVAVLKDGVLQQVDTPRA FT LYDDPVNTFVATFIGAPAMNLIDAAVAHGVVRAPDLAIPVPDPAAERVLVGVRPESWDV FT ASIGTPGSLTVHVELVEELGFESFVYATPVDQRGWSSRAPRIVFRTDRRTAVRVGESLA FT IVPHSQEVRLFNSRTETRLR" FT misc_feature complement(19695..19739) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(20010..20033) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(20137..21447) FT /transl_table=11 FT /gene="ugpB" FT /locus_tag="Rv2833c" FT /product="PROBABLE Sn-GLYCEROL-3-PHOSPHATE-BINDING FT LIPOPROTEIN UGPB" FT /function="INVOLVED IN ACTIVE TRANSPORT OF FT Sn-GLYCEROL-3-PHOSPHATE AND GLYCEROPHOSPHORYL DIESTERS FT ACROSS THE MEMBRANE (IMPORT). Sn-GLYCEROL-3-PHOSPHATE AND FT GLYCEROPHOSPHORYL DIESTERS - BINDING PROTEIN INTERACTS WITH FT THE BINDING PROTEIN-DEPENDENT TRANSPORT SYSTEM UGPACE." FT /note="Rv2833c, (MTCY16B7.09), len: 436 aa. Probable ugpB, FT Sn-glycerol-3-phosphate binding lipoprotein component of FT Sn-glycerol-3-phosphate transport system (see citation FT below), similar to various transporters substrate-binding FT periplasmic proteins e.g. Q9KDY2|BH1079 FT GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (GLYCEROL-3-PHOSPHATE FT BINDING PROTEIN) from Bacillus halodurans (459 aa), FASTA FT scores: opt: 357, E(): 3.1e-14, (23.4% identity in 406 aa FT overlap); P72397|MALE PUTATIVE MALTOSE-BINDING PROTEIN from FT Streptomyces coelicolor (423 aa), FASTA scores: opt: 318, FT E(): 7e-12, (23.7% identity in 430 aa overlap); FT AAK78409|CAC0429 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER FT PERIPLASMIC COMPONENT from Clostridium acetobutylicum (447 FT aa), FASTA scores: opt: 305, E(): 4.5e-11, (27.15% identity FT in 438 aa overlap); P10904|UGPB_ECOLI|B3453 FT GLYCEROL-3-PHOSPHATE-BINDING PERIPLASMIC PROTEIN PRECURSOR FT from Escherichia coli strain K12 (438 aa); etc. Contains FT signal sequence and appropriately positioned prokaryotic FT lipoprotein attachment site (PS00013)." FT /db_xref="GOA:P71619" FT /db_xref="InterPro:IPR006311" FT /db_xref="UniProtKB/TrEMBL:P71619" FT /protein_id="CAB03653.1" FT /translation="MDPLNRRQFLALAAAAAGVTAGCAGMGGGGSVKSGSGPIDFWSSH FT PGQSSAAERELIGRFQDRFPTLSVKLIDAGKDYDEVAQKFNAALIGTDVPDVVLLDDRW FT WFHFALSGVLTALDDLFGQVGVDTTDYVDSLLADYEFNGRHYAVPYARSTPLFYYNKAA FT WQQAGLPDRGPQSWSEFDEWGPELQRVVGAGRSAHGWANADLISWTFQGPNWAFGGAYS FT DKWTLTLTEPATIAAGNFYRNSIHGKGYAAVANDIANEFATGILASAVASTGSLAGITA FT SARFDFGAAPLPTGPDAAPACPTGGAGLAIPAKLSEERKVNALKFIAFVTNPTNTAYFS FT QQTGYLPVRKSAVDDASERHYLADNPRARVALDQLPHTRTQDYARVFLPGGDRIISAGL FT ESIGLRGADVTKTFTNIQKRLQVILDRQIMRKLAGHG" FT CDS complement(21450..22277) FT /transl_table=11 FT /gene="ugpE" FT /locus_tag="Rv2834c" FT /product="PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT FT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPE" FT /function="INVOLVED IN ACTIVE TRANSPORT OF FT Sn-GLYCEROL-3-PHOSPHATE ACROSS THE MEMBRANE (IMPORT). FT RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS FT THE MEMBRANE." FT /note="Rv2834c, (MTCY16B7.08), len: 275 aa. Probable ugpE, FT Sn-glycerol-3-phosphate transport integral membrane protein FT ABC transporter (see citation below), similar to various FT permeases e.g. Q9KDY3|BH1078 GLYCEROL-3-PHOSPHATE ABC FT TRANSPORTER from Bacillus halodurans (270 aa), FASTA FT scores: opt: 620, E(): 4.3e-32, (34.7% identity in 268 aa FT overlap); Q9X0K6|TM1122 GLYCEROL-3-PHOSPHATE ABC FT TRANSPORTER PERMEASE PROTEIN from Thermotoga maritima (276 FT aa), FASTA scores: opt: 605, E(): 3.9e-31, (32.5% identity FT in 274 aa overlap); AAG58557|UGPE SN-GLYCEROL 3-PHOSPHATE FT TRANSPORT SYSTEM (INTEGRAL MEMBRANE PROTEIN) from FT Escherichia coli strain O157:H7 and EDL933 (281 aa), FASTA FT scores: opt: 574, E(): 3.7e-29, (32.95% identity in 264 aa FT overlap); P10906|UGPE_ECOLI|B3451 SN-GLYCEROL-3-PHOSPHATE FT TRANSPORT SYSTEM PERMEASE PROTEIN from Escherichia coli FT strain K12 (281 aa), FASTA scores: opt: 569, E(): 7.6e-29, FT (32.6% identity in 264 aa overlap); etc. Contains PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp signature." FT /db_xref="GOA:P71618" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:P71618" FT /protein_id="CAB03652.1" FT /translation="MTPDRLRSSVGYAAMLLVVTLIAGPLLFVFFTSFKDQPDIYAQPT FT SWWPLRWYPQNYRTATEQIPFWTFLRNSLIITSVLAVVKFTLGVLSAFGLVFVRFPGRT FT AVFLVIIAALMVPNQITVISNYALISHLGLRNTFAGIILPLAGVAFGTFLMRNHFLSLP FT AEIIEAARMDGARWWQLLLRVVLPMSRPTMVAVGVITVVNEWNEYLWPFLMSDDESVAP FT LPIGLTFLQQAEGVTNWGPVMAVTLLAMLPILLVFIALQRQMIKGLTSGAVKG" FT misc_feature complement(21717..21803) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp signature" FT CDS complement(22274..23185) FT /transl_table=11 FT /gene="ugpA" FT /locus_tag="Rv2835c" FT /product="PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT FT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPA" FT /function="INVOLVED IN ACTIVE TRANSPORT OF FT Sn-GLYCEROL-3-PHOSPHATE ACROSS THE MEMBRANE (IMPORT). FT RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS FT THE MEMBRANE." FT /note="Rv2835c, (MTCY1B7.07), len: 303 aa. Probable ugpA, FT Sn-glycerol-3-phosphate transport integral membrane protein FT ABC transporter (see citation below), similar to various FT permeases e.g. Q9RK71|SCF11.19 PROBABLE SUGAR TRANSPORTER FT INNER MEMBRANE PROTEIN from Streptomyces coelicolor (316 FT aa), FASTA scores: opt: 643, E(): 3.1e-35, (38.85% identity FT in 291 aa overlap); Q9KDY4|BH1077 GLYCEROL-3-PHOSPHATE ABC FT TRANSPORTER (PERMEASE) from Bacillus halodurans (315 aa), FT FASTA scores: opt: 548, E(): 6.2e-29, (31.5% identity in FT 295 aa overlap); AAK78407|CAC0427 GLYCEROL-3-PHOSPHATE FT ABC-TRANSPORTER, PERMEASE COMPONENT from Clostridium FT acetobutylicum (304 aa), FASTA scores: opt: 538, E(): FT 2.8e-28, (29.1% identity in 292 aa overlap); etc. Contains FT PS00062 Aldo/keto reductase family signature 2, and PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp signature." FT /db_xref="GOA:P71617" FT /db_xref="InterPro:IPR018170" FT /db_xref="UniProtKB/TrEMBL:P71617" FT /protein_id="CAB03651.1" FT /translation="MAAPQRARLRSSKERVRDYALFVVLVGPNVALLLLFVYRPLADNI FT RLSFFDWNVSDPSARFVGLSNYTEWFTRSDTRQIVFNTAVFTGAAVVGSMVLGLALAML FT LDRPLRGRNLVRSTVFAPFVISGAAVGLAAQFVFDPHFGLIQDLLRRIGVGVPDFYQDA FT RWALFMVTITYVWKNLGYTFVIYLAALQGVRRDLLEAAEIDGASRWAVFRRVLLPQLRP FT TTFFLSITVLINSLQVFDVINVMTRGGPEGTGTTTMVYQVYVETFRNFRAGYGATVATI FT MFLVLLAVTYYQVRVMDRGQRQ" FT misc_feature complement(22532..22618) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp signature" FT misc_feature complement(22985..23038) FT /note="PS00062 Aldo/keto reductase family signature 2" FT CDS complement(23272..24591) FT /transl_table=11 FT /gene="dinF" FT /locus_tag="Rv2836c" FT /product="POSSIBLE DNA-DAMAGE-INDUCIBLE PROTEIN F DINF" FT /function="UNKNOWN; INDUCTION BY DNA DAMAGE." FT /note="Rv2836c, (MTCY16B7.06), len: 439 aa. Possible dinF, FT DNA-damage-inducible protein F, integral membrane protein, FT similar to others e.g. BAB38450|ECS5027|AAG59243 from FT Escherichia coli strain O157:H7 (459 aa), FASTA scores: FT opt: 501, E(): 2.7e-21, (29.55% identity in 443 aa FT overlap); P28303|DINF_ECOLI|B4044 from Escherichia coli FT strain K12 (459 aa), FASTA scores: opt: 491, E(): 1e-20, FT (29.35% identity in 443 aa overlap); Q98B90|MLR5680 from FT Rhizobium loti (Mesorhizobium loti) (471 aa), FASTA scores: FT opt: 466, E(): 2.7e-19, (30.7% identity in 433 aa overlap); FT etc. But also similar or highly similar to other FT hypothetical proteins e.g. Q9X8U6|SCH24.32c HYPOTHETICAL FT 46.3 KDA PROTEIN from Streptomyces coelicolor (448 aa), FT FASTA scores: opt: 981, E(): 1.1e-48, (42.35% identity in FT 437 aa overlap). Contains PS00213 Lipocalin signature." FT /db_xref="GOA:P71616" FT /db_xref="InterPro:IPR002528" FT /db_xref="UniProtKB/TrEMBL:P71616" FT /protein_id="CAB03650.1" FT /translation="MSQVGHRAGGRQIAQLALPALGVLAAEPLYLLFDIAVVGRLGAIS FT LAGLAIGSLVLGLVGSQATFLSYGTTARAARRYGAGNRVAAVTEGVQATWLALGLGALV FT VVVVEATATPLVSAIASGDGITAAALPWLRIAILGTPAILVSLAGNGWLRGVQDTVRPL FT RYVVAGFGSSALLCPLLVYGWLGLPRWGLTGSAVANLVGQWLAALLFAGALLAERVSLR FT PDRAVLGAQLMMARDLIVRTLAFQVCYVSAAAVAARFGAAALAAHQVVLQLWGLLALVL FT DSLAIAAQSLVGAALGAGDAGHAKAVAWRVTAFSLLAAGILAAALGLGSSVLPGLFTDD FT RSVLAAIGVPWWFMVVQLPFAGIVFAVDGVLLGAGDAAFMRTATVASALVGFLPLVWLS FT LAYGWGLAGIWSGLGTFIVLRLIFVGWRAYSGRWAVTGAA" FT misc_feature complement(23971..24012) FT /note="PS00213 Lipocalin signature" FT CDS complement(24598..25608) FT /transl_table=11 FT /locus_tag="Rv2837c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2837c, (MTCY16B7.05), len: 336 aa. Conserved FT hypothetical protein, showing some similarity with other FT proteins e.g. O67552|AQ_1630 HYPOTHETICAL 36.2 KDA PROTEIN FT from Aquifex aeolicus (325 aa), FASTA scores: opt: 498, FT E(): 3.6e-25, (32.8% identity in 314 aa overlap); FT Q9X1T1|TM1595 CONSERVED HYPOTHETICAL PROTEIN from FT Thermotoga maritima (333 aa), FASTA scores: opt: 482, E(): FT 4.1e-24, (34.85% identity in 304 aa overlap); Q9RW43|DR0826 FT CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans FT (338 aa), FASTA scores: opt: 444, E(): 1.3e-21, (33.85% FT identity in 331 aa overlap); etc. Equivalent to AAK47229 FT from Mycobacterium tuberculosis strain CDC1551 (316 aa) but FT longer 20 aa." FT /db_xref="GOA:P71615" FT /db_xref="InterPro:IPR001667" FT /db_xref="UniProtKB/TrEMBL:P71615" FT /protein_id="CAB03672.1" FT /translation="MTTIDPRSELVDGRRRAGARVDAVGAAALLSAAARVGVVCHVHPD FT ADTIGAGLALALVLDGCGKRVEVSFAAPATLPESLRSLPGCHLLVRPEVMRRDVDLVVT FT VDIPSVDRLGALGDLTDSGRELLVIDHHASNDLFGTANFIDPSADSTTTMVAEILDAWG FT KPIDPRVAHCIYAGLATDTGSFRWASVRGYRLAARLVEIGVDNATVSRTLMDSHPFTWL FT PLLSRVLGSAQLVSEAVGGRGLVYVVVDNREWVAARSEEVESIVDIVRTTQQAEVAAVF FT KEVEPHRWSVSMRAKTVNLAAVASGFGGGGHRLAAGYTTTGSIDDAVASLRAALG" FT CDS complement(25583..26134) FT /transl_table=11 FT /gene="rbfA" FT /locus_tag="Rv2838c" FT /product="PROBABLE RIBOSOME-BINDING FACTOR A RBFA (P15B FT PROTEIN)" FT /function="ASSOCIATES WITH FREE 30S RIBOSOMAL SUBUNITS (BUT FT NOT WITH 30S SUBUNITS THAT ARE PART OF 70S RIBOSOMES OR FT POLYSOMES). ESSENTIAL FOR EFFICIENT PROCESSING OF 16S RRNA. FT MAY INTERACT WITH THE 5'TERMINAL HELIX REGION OF 16S SRNA." FT /note="Rv2838c, (MTCY16B7.04), len: 183 aa. Probable rbfA, FT ribosome-binding factor A, equivalent to FT Q9Z5I8|RBFA_MYCLE|ML1555|MLCB596.15 PROBABLE FT RIBOSOME-BINDING FACTOR A from Mycobacterium leprae (164 FT aa), FASTA scores: opt: 739, E(): 1.8e-40, (75.6% identity FT in 160 aa overlap). Also highly similar or similar to FT others e.g. Q9Z527|RBFA_STRCO|SC9F2.08c from Streptomyces FT coelicolor (160 aa), FASTA scores: opt: 425, E(): 2.8e-20, FT (50.35% identity in 141 aa overlap); P32731|RBFA_BACSU from FT Bacillus subtilis (117 aa), FASTA scores: opt: 199, E(): FT 7.8e-06, (32.4% identity in 108 aa overlap); FT P09170|RBFA_ECOLI|P15B|B3167 from Escherichia coli strain FT K12 (132 aa), FASTA scores: opt: 166, E(): 0.0011, (29.65% FT identity in 118 aa overlap); etc. BELONGS TO THE RBFA FT FAMILY. Note that appears to be longer in C-terminus than FT other RbfA proteins." FT /db_xref="GOA:P65964" FT /db_xref="HSSP:1KKG" FT /db_xref="InterPro:IPR020053" FT /db_xref="UniProtKB/Swiss-Prot:P65964" FT /protein_id="CAB03671.1" FT /translation="MADAARARRLAKRIAAIVASAIEYEIKDPGLAGVTITDAKVTADL FT HDATVYYTVMGRTLHDEPNCAGAAAALERAKGVLRTKVGAGTGVRFTPTLTFTLDTISD FT SVHRMDELLARARAADADLARVRVGAKPAGEADPYRDNGSVAQSPAPGGLGIRTSDGPE FT AVEAPLTCGGDTGDDDRPKE" FT CDS complement(26134..28836) FT /transl_table=11 FT /gene="infB" FT /locus_tag="Rv2839c" FT /product="PROBABLE TRANSLATION INITIATION FACTOR IF-2 INFB" FT /function="IF-2, ONE OF THE ESSENTIAL COMPONENTS FOR THE FT INITIATION OF PROTEIN SYNTHESIS IN VITRO, PROTECTS FT FORMYLMETHIONYL-TRNA FROM SPONTANEOUS HYDROLYSIS AND FT PROMOTES ITS BINDING TO THE 30S RIBOSOMAL SUBUNITS. IT IS FT ALSO INVOLVED IN THE HYDROLYSIS OF GTP DURING THE FORMATION FT OF THE 70S RIBOSOMAL COMPLEX." FT /note="Rv2839c, (MTCY16B7.03), len: 900 aa. Probable infB, FT translation initiation factor IF-2, highly similar, but in FT part, to Q9Z5I9|IF2_MYCLE|ML1556|MLCB596.14 TRANSLATION FT INITIATION FACTOR IF-2 from Mycobacterium leprae (924 aa), FT FASTA scores: opt: 4548, E(): 2.4e-132, (83.6% identity in FT 933 aa overlap). Also similar in part to others e.g. FT Q9K3E2|SC5H4.30 from Streptomyces coelicolor (835 aa), FT FASTA scores: opt: 2559, E(): 1.3e-71, (59.9% identity in FT 833 aa overlap); P17889|IF2_BACSU|INFB from Bacillus FT subtilis (716 aa), FASTA scores: opt: 1782, E(): 6.6e-48, FT (46.65% identity in 686 aa overlap); FT P02995|IF2_ECOLI|INFB|SSYG|B3168|Z4529|ECS4049 from FT Escherichia coli strains O157:H7 and K12 (890 aa), FASTA FT scores: opt: 1708, E(): 1.3e-45, (46.2% identity in 662 aa FT overlap); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop). BELONGS TO THE IF-2 FAMILY." FT /db_xref="GOA:P65131" FT /db_xref="HSSP:1G7S" FT /db_xref="InterPro:IPR004161" FT /db_xref="UniProtKB/Swiss-Prot:P65131" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB03670.1" FT /translation="MAAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTVEAPVA FT RRLRESFGGSKPAPAKGTAKSPGKGPDKSLDKALDAAIDMAAGNGKATAAPAKAADSGG FT AAIVSPTTPAAPEPPTAVPPSPQAPHPGMAPGARPGPVPKPGIRTPRVGNNPFSSAQPA FT DRPIPRPPAPRPGTARPGVPRPGASPGSMPPRPGGAVGGARPPRPGAPRPGGRPGAPGA FT GRSDAGGGNYRGGGVGAAPGTGFRGRPGGGGGGRPGQRGGAAGAFGRPGGAPRRGRKSK FT RQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFADKIDANPAALVQALFNLGE FT MVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLSYGEDEGGEEDLQVRPP FT VVTVMGHVDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVAVDLDGSQRLITFIDTPG FT HEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGAD FT PAKIRGQLTEYGLVPEEFGGDTMFVDISAKQGTNIEALEEAVLLTADAALDLRANPDME FT AQGVAIEAHLDRGRGPVATVLVQRGTLRVGDSVVAGDAYGRVRRMVDEHGEDVEVALPS FT RPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSRKRISLEDLDSAL FT KETSQLNLILKGDNAGTVEALEEALMGIQVDDEVVLRVIDRGVGGITETNVNLASASDA FT VIIGFNVRAEGKATELASREGVEIRYYSVIYQAIDEIEQALRGLLKPIYEENQLGRAEI FT RALFRSSKVGLIAGCLVTSGVMRRNAKARLLRDNIVVAENLSIASLRREKDDVTEVRDG FT FECGLTLGYADIKEGDVIESYELVQKERA" FT misc_feature complement(27601..27624) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(28922..29221) FT /transl_table=11 FT /locus_tag="Rv2840c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2840c, (MTCY16B7.02), len: 99 aa. Conserved FT hypothetical protein, equivalent to FT Q9Z5J0|ML1557|MLCB596.13 HYPOTHETICAL 11.6 KDA PROTEIN from FT Mycobacterium leprae (106 aa), FASTA scores: opt: 501, E(): FT 2.3e-29, (501% identity in 96 aa overlap). Also highly FT similar to other hypothetical proteins e.g. Q9KYR0|SC5H4.29 FT from Streptomyces coelicolor (101 aa), FASTA scores: opt: FT 256, E(): 1.4e-11, (50.6% identity in 81 aa overlap); FT Q9APM9 from Myxococcus xanthus (111 aa), FASTA scores: opt: FT 174, E(): 1.3e-05, (42.25% identity in 97 aa overlap); and FT similar to to others e.g. N-terminus of CAC41675|SMC02913 FT from Rhizobium meliloti (Sinorhizobium meliloti) (230 aa), FT FASTA scores: opt: 172, E(): 3e-05, (42.4% identity in 66 FT aa overlap)." FT /db_xref="InterPro:IPR007393" FT /db_xref="UniProtKB/TrEMBL:P71612" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB03669.1" FT /translation="MRTCVGCRKRGLAVELLRVVAVSTGNGNYAVIVDTATSLPGRGAW FT LHPLRQCAQQAIRRRAFARALRIAGSPDTSAVVEYLESLGELEPPGNRTGSNRT" FT CDS complement(29348..30391) FT /transl_table=11 FT /gene="nusA" FT /locus_tag="Rv2841c" FT /product="PROBABLE N UTILIZATION SUBSTANCE PROTEIN A NUSA" FT /function="COULD PARTICIPATES IN BOTH THE TERMINATION AND FT ANTITERMINATION OF TRANSCRIPTION." FT /note="Rv2841c, (MTCY24A1.16, MTCY16B7.01), len: 347 aa. FT Probable nusA, N-utilization substance protein A, FT equivalent to Q9Z5J1|NUSA|ML1558 PROBABLE TRANSCRIPTION FT TERMINATION/ANTITERMINATION FACTOR from Mycobacterium FT leprae (347 aa), FASTA scores: opt: 2054, E(): 5.4e-120, FT (91.95% identity in 347 aa overlap). Also highly similar to FT others e.g. Q9KYR1|SC5H4.28 PUTATIVE TRANSCRIPTIONAL FT TERMINATION/ANTITERMINATION FACTOR from Streptomyces FT coelicolor (340 aa), FASTA scores: opt: 1346, E(): 4.3e-76, FT (63.35% identity in 341 aa overlap); P32727|NUSA_BACSU N FT UTILIZATION SUBSTANCE PROTEIN A (371 aa), FASTA scores: FT opt: 847, E(): 4.1e-45, (43.95% identity in 346 aa FT overlap); Q9KA74|NUSA|BH2416 TRANSCRIPTIONAL TERMINATOR FT from Bacillus halodurans (382 aa), FASTA scores: opt: 846, FT E(): 4.8e-45, (43.15% identity in 373 aa overlap); etc. FT BELONGS TO THE NUSA FAMILY." FT /db_xref="GOA:P0A5M2" FT /db_xref="InterPro:IPR004087" FT /db_xref="PDB:1K0R" FT /db_xref="UniProtKB/Swiss-Prot:P0A5M2" FT /protein_id="CAB08449.1" FT /translation="MNIDMAALHAIEVDRGISVNELLETIKSALLTAYRHTQGHQTDAR FT IEIDRKTGVVRVIARETDEAGNLISEWDDTPEGFGRIAATTARQVMLQRFRDAENERTY FT GEFSTREGEIVAGVIQRDSRANARGLVVVRIGTETKASEGVIPAAEQVPGESYEHGNRL FT RCYVVGVTRGAREPLITLSRTHPNLVRKLFSLEVPEIADGSVEIVAVAREAGHRSKIAV FT RSNVAGLNAKGACIGPMGQRVRNVMSELSGEKIDIIDYDDDPARFVANALSPAKVVSVS FT VIDQTARAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRGDAPPPPPGQPEPGVS FT RGMAHDR" FT CDS complement(30388..30939) FT /transl_table=11 FT /locus_tag="Rv2842c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2842c, (MTCY24A1.15), len: 183 aa. Conserved FT hypothetical protein, similar to Q9Z5J2|MLCB596.11 FT HYPOTHETICAL 13.7 KDA PROTEIN from Mycobacterium leprae FT (122 aa), FASTA scores: opt: 192, E(): 2.1e-12, (50.0% FT identity in 128 aa overlap) (N-terminus shorter). Also FT similar in part to several hypothetical proteins e.g. FT Q9KYR2|SC5H4.27 HYPOTHETICAL 19.8 KDA PROTEIN from FT Streptomyces coelicolor (177 aa), FASTA scores: opt: 288, FT E(): 2.1e-12, (37.15% identity in 148 aa overlap); FT O66619|Y260_AQUAE|AQ_260 HYPOTHETICAL PROTEIN from Aquifex FT aeolicus (158 aa), FASTA scores: opt: 230, E(): 1.7e-08, FT (31.35% identity in 153 aa overlap); Q9KU82|VC0641 FT HYPOTHETICAL PROTEIN from Vibrio cholerae (151 aa), FASTA FT scores: opt: 198, E(): 2.5e-06, (30.9% identity in 152 aa FT overlap); etc." FT /db_xref="InterPro:IPR003728" FT /db_xref="UniProtKB/Swiss-Prot:P67214" FT /protein_id="CAB08448.1" FT /translation="MTTGLPSQRQVIELLGADFACAGYEIEDVVIDARARPPRIAVIAD FT GDAPLDLDTIAALSRRASALLDGLDGANKIRGRYLLEVSSPGVERPLTSEKHFRRARGR FT KVELVLSDGSRLTGRVGEMRAGTVALVIREDRGWAVREIPLAEIVKAVVQVEFSPPAPA FT ELELAQSSEMGLARGTEAGA" FT CDS 31134..31679 FT /transl_table=11 FT /locus_tag="Rv2843" FT /product="PROBABLE CONSERVED TRANSMEMBRANE ALANINE RICH FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv2843, (MTCY24A1.14c), len: 181 aa. Probable FT conserved transmembrane ala-rich protein, equivalent to FT Q9Z5J3|ML1560|MLCB596.10c HYPOTHETICAL 17.5 KDA PROTEIN FT from Mycobacterium leprae (178 aa), FASTA scores: opt: 707, FT E(): 1.4e-32, (70.25% identity in 168 aa overlap)." FT /db_xref="GOA:O05816" FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/TrEMBL:O05816" FT /protein_id="CAB08447.1" FT /translation="MLRAAPVINRLTNRPISRRGVLAGGAALAALGVVSACGESAPKAP FT AVEELRSPLDQARHDGALAAAAATAIGIPPQVAAALTVVATQRTSHARALATEIARAAG FT KLVSATSETSSSSPSPTDPAAPPPAVSDVIDSLRTSAGEASRLVATTSGYRAGLLASIA FT ASCTASYTVALVPSGPSI" FT CDS 31676..32164 FT /transl_table=11 FT /locus_tag="Rv2844" FT /product="CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2844, (MTCY24A1.13c), len: 162 aa. Conserved FT hypothetical ala-rich protein, equivalent to FT Q9Z5J4|ML1561|MLCB596.09c HYPOTHETICAL 17.5 KDA PROTEIN FT from Mycobacterium leprae (165 aa), FASTA scores: opt: 771, FT E(): 4.9e-46, (71.5% identity in 165 aa overlap). Also FT similar to Q9KYR4|SC5H4.25c HYPOTHETICAL 16.8 KDA PROTEIN FT from Streptomyces coelicolor (167 aa), FASTA scores: opt: FT 242, E(): 1.6e-09, (38.9% identity in 144 aa overlap)." FT /db_xref="PDB:2IB0" FT /db_xref="UniProtKB/TrEMBL:O05815" FT /protein_id="CAB08446.1" FT /translation="MTSSEPAHGATPKRSPSEGSADNAALCDALAVEHATIYGYGIVSA FT LSPPGVNFLVADALKQHRHRRDDVIVMLSARGVTAPIAAAGYQLPMQVSSAADAARLAV FT RMENDGATAWRAVVEHAETADDRVFASTALTESAVMATRWNRVLGAWPITAAFPGGDE" FT CDS complement(32165..33913) FT /transl_table=11 FT /gene="proS" FT /locus_tag="Rv2845c" FT /product="PROBABLE PROLYL-TRNA SYNTHETASE PROS FT (PROLINE--TRNA LIGASE) (PRORS) (GLOBAL RNA SYNTHESIS FT FACTOR) (PROLINE TRANSLASE)" FT /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC FT ACTIVITY: ATP + L-PROLINE + TRNA(PRO) = AMP + PYROPHOSPHATE FT + L-PROLYL-TRNA(PRO)]." FT /EC_number="6.1.1.15" FT /note="Rv2845c, (MTCY24A1.12), len: 582 aa. Probable proS, FT prolyl-tRNA synthetase (EC 6.1.1.15), highly similar to FT others e.g. Q9KYR6|SYP_STRCO|PROS|SC5H4.23 from FT Streptomyces coelicolor (567 aa), FASTA scores: opt: 1161, FT E(): 9e-64, (57.15% identity in 574 aa overlap); FT P56124|SYP_HELPY|PROS|HP0238 from Helicobacter pylori FT (Campylobacter pylori) (577 aa), FASTA scores: opt: 1082, FT E(): 6.6e-59, (37.8% identity in 553 aa overlap); FT P16659|SYP_ECOLI|PROS|DRPA|B0194 from Escherichia coli FT strain K12 (572 aa), FASTA scores: opt: 926, E(): 2.6e-49, FT (39.85% identity in 587 aa overlap); etc. Contains PS00179 FT Aminoacyl-transfer RNA synthetases class-II signature 1. FT BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:O05814" FT /db_xref="InterPro:IPR007214" FT /db_xref="UniProtKB/Swiss-Prot:O05814" FT /protein_id="CAB08445.1" FT /translation="MITRMSELFLRTLRDDPADAEVASHKLLIRAGYIRPVAPGLYSWL FT PLGLRVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLKDRRGN FT DYLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDEARPRAGILRAREFVMKDSY FT SFDIDAAGLKAAYHAHREAYQRIFDRLQVRYVIVSAVSGAMGGSASEEFLAESPSGEDA FT FVRCLESGYAANVEAVVTARPDTLPIDGLPEAVVHDTGDTPTIASLVAWANEADLGRTV FT TAADTLKNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFAKHP FT FLVKGYIGPKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLVAGRDFTADGTIEA FT AEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDAFTADVLGEDGKPVRLTMGSYGI FT GVSRLVAVVAEQHHDELGLRWPSTVAPFDVHLVIANKDAQARAGATALAADLDRLGVEV FT LLDDRQASPGVKFKDAELLGMPWIVVVGRGWADGVVELRDRFSGQTRELVAGASLATDI FT AAAVTG" FT misc_feature complement(33431..33493) FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT CDS complement(34002..35594) FT /transl_table=11 FT /gene="efpA" FT /locus_tag="Rv2846c" FT /product="POSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA" FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF FT UNDETERMINATED SUBSTRATE (POSSIBLY DRUG) ACROSS THE FT MEMBRANE (EXPORT): SO RESPONSIBLE FOR THE TRANSLOCATION OF FT THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2846c, (MTCY24A1.11), len: 530 aa. Possible efpA, FT integral membrane efflux protein, member of major FT facilitator superfamily (MFS) possibly involved in FT transport of drug (see citations below), equivalent to FT Q9Z5J5|ML1562|MLCB596.08 PUTATIVE TRANSMEMBRANE EFFLUX FT PROTEIN from Mycobacterium leprae (534 aa), FASTA scores: FT opt: 2881, E(): 4.1e-160, (86.55% identity in 535 aa FT overlap). Also highly similar to several membrane proteins FT e.g. O69986|SC4H2.31c TRANSMEMBRANE EFFLUX PROTEIN (515 FT aa), FASTA scores: opt: 1063, E(): 2.2e-54, (39.65% FT identity in 406 aa overlap); Q9FBQ5|SCD86A.02c PUTATIVE FT TRANSPORT INTEGRAL MEMBRANE PROTEIN from Streptomyces FT coelicolor (503 aa), FASTA scores: opt: 918, E(): 5.8e-46, FT (33.7% identity in 469 aa overlap); Q9KYU0|SCE22.23c FT PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces FT coelicolor (514 aa), FASTA scores: opt: 888, E(): 3.3e-44, FT (32.85% identity in 469 aa overlap); etc." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:O05813" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08444.1" FT /translation="MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPTW FT LPSRSFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGL FT MLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGL FT ALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIY FT LARTALRETNKERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAA FT VAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSAL FT RAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFP FT NLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVI FT TSRTLYLGGTTGPVKFMNDVQLAALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAH FT AQEVKEAIDAGEL" FT CDS complement(35617..36834) FT /transl_table=11 FT /gene="cysG" FT /locus_tag="Rv2847c" FT /standard_name="cysG2" FT /product="POSSIBLE MULTIFUNCTIONAL ENZYME SIROHEME SYNTHASE FT CYSG: UROPORPHYRIN-III C-METHYLTRANSFERASE (UROGEN III FT METHYLASE) (SUMT) (UROPORPHYRINOGEN III METHYLASE) (UROM) + FT PRECORRIN-2 OXIDASE + FERROCHELATASE" FT /function="INVOLVED IN THE BIOSYNTHESIS OF SIROHEME AND FT COBALAMIN [CATALYTIC ACTIVITY: 2 S-ADENOSYL-L-METHIONINE + FT UROPORPHYRIN III = 2 S-ADENOSYL-L-HOMOCYSTEINE + FT SIROHYDROCHLORIN]. SAM-DEPENDENT METHYL TRANSFERASE THAT FT METHYLATES UROPORPHYRINOGEN III AT POSITION C-2 AND C-7 TO FT FORM PRECORRIN-2 AND THEN POSITION C-12 OR C-18 TO FORM FT TRIMETHYLPYRROCORPHIN 2. IT CATALYZES ALSO THE CONVERSION FT OF PRECORRIN-2 INTO SIROHEME (CONSISTING OF AN OXIDATION FT AND FE(2+) CHELATION)." FT /EC_number="2.1.1.107" FT /EC_number="1.-.-.-" FT /EC_number="4.99.1.-" FT /note="Rv2847c, (MTCY24A1.10), len: 405 aa. Possible cysG, FT multifunctional enzyme, siroheme synthase containing FT uroporphyrin-iii c-methyltransferase (EC 2.1.1.107), FT precorrin-2 oxidase (EC 1.-.-.-) and ferrochelatase (EC FT 4.99.1.-). C-terminus highly similar to many FT uroporphyrin-iii c-methyltransferases e.g. Q51720|COBA FT UROPORPHYRINOGEN III METHYLTRANSFERASE from FT Propionibacterium freudenreichii (257 aa), FASTA scores: FT opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa FT overlap); Q9HMY4|UROM|VNG2331G FT S-ADENOSYL-L-METHIONINE:UROPORPHYRINOGEN III FT METHYLTRANSFERASE from Halobacterium sp. strain NRC-1 (246 FT aa), FASTA scores: opt: 704, E(): 3.1e-35, (49.4% identity FT in 245 aa overlap); P42437|NASF_BACSU|NASBE FT UROPORPHYRIN-III C-METHYLTRANSFERASE from Bacillus subtilis FT (483 aa), FASTA scores: opt: 610, E(): 2.4e-29, (42.1% FT identity in 240 aa overlap); etc. And highly similar over FT entire length to other proteins e.g. Q9L1C9|SCL11.09c FT UROPORPHYRINOGEN III METHYLTRANSFERASE from Streptomyces FT coelicolor (410 aa), FASTA scores: opt: 1481, E(): 5.6e-82, FT (58.45% identity in 409 aa overlap); Q9I0M7|CYSG|PA2611 FT SIROHEME SYNTHASE from Pseudomonas aeruginosa (465 aa), FT FASTA scores: opt: 609, E(): 2.7e-29, (34.7% identity in FT 444 aa overlap); P11098|CYSG_ECOLI|B3368|Z4729|ECS4219 FT SIROHEME SYNTHASE from Escherichia coli stains O157:H7 and FT K12 (457 aa), FASTA scores: opt: 543, E(): 9.1e-27, (31.3% FT identity in 450 aa overlap); etc. BELONGS TO A FAMILY THAT FT GROUPS SUMT, CYSG, CBIF/COBM AND CBIL/COBI. Note that FT previously known as cysG2." FT /db_xref="GOA:P95077" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95077" FT /protein_id="CAB06239.2" FT /translation="MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAP FT SVTPAVEAMDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADI FT AVEGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVA FT LVGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMA FT QDAINAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVP FT AMAGVPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDV FT LLKGGRTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGV FT RGLNNS" FT repeat_region complement(36837..36890) FT /note="54 bp direct repeat 4, FT GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTAGGCTTGGC" FT repeat_region complement(36891..36944) FT /note="54 bp direct repeat 3, FT GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT" FT repeat_region complement(36945..36998) FT /note="54 bp direct repeat 2, FT GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT" FT repeat_region complement(36999..37052) FT /note="54 bp direct repeat 1, FT GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT" FT CDS complement(37111..38484) FT /transl_table=11 FT /gene="cobB" FT /locus_tag="Rv2848c" FT /product="PROBABLE COBYRINIC ACID A,C-DIAMIDE SYNTHASE FT COBB" FT /function="INVOLVED IN THE COBALAMIN BIOSYNTHESIS. FT RESPONSIBLE FOR THE AMIDATION OF CARBOXYLIC GROUPS AT FT POSITION A AND C OF EITHER COBYRINIC ACID OR FT HYDROGENOBRYNIC ACID. NH(2) GROUPS ARE PROVIDED BY FT GLUTAMINE, AND ONE MOLECULE OF ATP IS HYDROGENOLYZED FOR FT EACH AMIDATION." FT /note="Rv2848c, (MTCY24A1.09), len 457 aa. Probable cobB, FT cobyrinic acid A,C-diamide synthase, highly similar to FT others e.g. O27509|COBB_METTH|MTH1460 from Methanobacterium FT thermoautotrophicum (447 aa), FASTA scores: opt: 980, E(): FT 1.3e-49, (39.65% identity in 454 aa overlap); Q9KBM8|BH1898 FT from Bacillus halodurans (465 aa), FASTA scores: opt: 928, FT E(): 1.4e-46, (37.0% identity in 457 aa overlap); FT O68108|COBB_RHOCA from Rhodobacter capsulatus FT (Rhodopseudomonas capsulata) (435 aa), FASTA scores: opt: FT 921, E(): 3.3e-46, (39.35% identity in 437 aa overlap); FT etc. BELONGS TO THE COBB/COBQ FAMILY, COBB SUBFAMILY." FT /db_xref="GOA:P63835" FT /db_xref="InterPro:IPR011698" FT /db_xref="UniProtKB/Swiss-Prot:P63835" FT /protein_id="CAB08442.1" FT /translation="MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFI FT DPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGA FT PAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARH FT EQVLRQACDQAGVAVLGAIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHV FT DLAAVIACAGSQAAHPPWDPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAE FT VVEFDPLSETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGL FT LYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVT FT FADSYQPAWVYQGQDVDDVRDGAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA" FT CDS complement(38484..39107) FT /transl_table=11 FT /gene="cobO" FT /locus_tag="Rv2849c" FT /standard_name="cobA" FT /product="PROBABLE COB(I)ALAMIN ADENOSYLTRANSFERASE COBO FT (CORRINOID ADENOSYLTRANSFERASE) (CORRINOID ADOTRANSFERASE FT ACTIVITY)" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS; TRANSFORMS FT COBYRINIC ACID INTO COBINAMIDE [CATALYTIC ACTIVITY: ATP + FT COB(I)ALAMIN + H(2)O = ORTHOPHOSPHATE + PYROPHOSPHATE + FT ADENOSYLCOBALAMIN]." FT /EC_number="2.5.1.17" FT /note="Rv2849c, (MTCY24A1.08), len: 207 aa. Probable cobO, FT cob(I)alamin adenosyltransferase (EC 2.5.1.17), highly FT similar to Q9RJ17|COBO from Streptomyces coelicolor (199 FT aa), FASTA scores: opt: 918, E(): 1.1e-55, (64.75% identity FT in 207 aa overlap); and similar to others e.g. O30785|COBO FT from Rhodobacter capsulatus (Rhodopseudomonas capsulata) FT (212 aa), FASTA scores: opt: 329, E(): 2.8e-15, (44.3% FT identity in 185 aa overlap); P29930|COBO_PSEDE from FT Pseudomonas denitrificans (213 aa), FASTA scores: opt: 280, FT E(): 6.5e-12, (38.9% identity in 185 aa overlap); FT P31570|BTUR_SALTY|COBA from Salmonella typhimurium (196 FT aa), FASTA scores: opt: 278, E(): 8.4e-12, (39.8% identity FT in 196 aa overlap); etc. COFACTOR: MANGANESE. Note that FT previously known as cobA." FT /db_xref="GOA:Q7D6G6" FT /db_xref="InterPro:IPR003724" FT /db_xref="UniProtKB/TrEMBL:Q7D6G6" FT /protein_id="CAE55524.1" FT /translation="MPQGNPLAVPNDGLTTRARRNMPILAVHTGEGKGKSTAAFGMALR FT AWNAGLDIAVFQFVKSAKWKVGEEAAFRQLGRLHDQHGIGGAVEWHKMGAGWSWTRTSR FT KAGTDVDRAAAAADGWAEIALRLATQRHDFYLLDEFTYPLKWGWLDVDEVVDVLRARPG FT HQHVVITGRDAPQRLVAAADLVTEMTKVKHPMDAGRKGQKGIEW" FT CDS complement(39128..41017) FT /transl_table=11 FT /locus_tag="Rv2850c" FT /product="POSSIBLE MAGNESIUM CHELATASE" FT /function="UNKNOWN; POSSIBLY INTRODUCES A MAGNESIUM ION FT INTO SPECIFIC SUBSTRATE/COMPOUND." FT /EC_number="4.99.1.-" FT /note="Rv2850c, (MTCY24A1.07), len: 629 aa. Possible FT magnesium-chelatase (EC 4.99.1.-), highly similar (but with FT gaps) to magnesium-chelatases from notably photosynthetic FT organisms involved in chlorophyll biosynthesis e.g. FT Q9RJ18|SCI8.35c PUTATIVE CHELATASE from Streptomyces FT coelicolor (672 aa), FASTA scores: opt: 1941, E(): 2.1e-85, FT (54.65% identity in 675 aa overlap); Q9HZQ5|PA2942 PROBABLE FT MAGNESIUM CHELATASE from Pseudomonas aeruginosa (338 aa), FT FASTA scores: opt: 991, E(): 2.7e-40, (49.45% identity in FT 368 aa overlap); O33549|BCHI MG PROTOPORPHYRIN IX CHELATASE FT SUBUNIT from Rhodobacter sphaeroides (Rhodopseudomonas FT sphaeroides) (334 aa), FASTA scores: opt: 833, E(): FT 9.4e-33, (50.65% identity in 318 aa overlap); FT O30819|BCHI_RHOSH MAGNESIUM-CHELATASE 38 KDA SUBUNIT from FT Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 FT aa), FASTA scores: opt: 828, E(): 1.6e-32, (50.3% identity FT in 318 aa overlap); etc. Equivalent to AAK47242 from FT Mycobacterium tuberculosis strain CDC1551 (610 aa) but FT longer 19 aa. COULB BELONG TO THE MG-CHELATASE SUBUNITS D/I FT FAMILY." FT /db_xref="GOA:O05809" FT /db_xref="HSSP:1G8P" FT /db_xref="InterPro:IPR002035" FT /db_xref="UniProtKB/Swiss-Prot:O05809" FT /protein_id="CAB08456.1" FT /translation="MKPYPFSAIVGHDRLRLALLLCAVRPEIGGALIRGEKGTAKSTAV FT RGLAALLSVATGSTETGLVELPLGATEDRVVGSLDLQRVMRDGEHAFSPGLLARAHGGV FT LYVDEVNLLHDHLVDILLDAAAMGRVHVERDGISHSHEARFVLIGTMNPEEGELRPQLL FT DRFGLTVDVQASRDIDVRVQVIRRRMAYEADPDAFVARYADADAELAHRIAAARATVDD FT VVLGDNELRRIAALCAAFDVDGMRADLVVARTAAAHAAWRGVRTVEEQDIRAAAELALP FT HRRRRDPFDDHGIDRDQLDEALALASVDPEPEPDPPGGGQSANEPASQPNSRSKSTEPG FT APSSMGDDPPRPASPRLRSSPRPSAPPSKIFRTRALRVPGVGTGAPGRRSRARNASGSV FT VAAAEVSDPDAHGLHLFATLLAAGERAFGAGPLRPWPDDVRRAIREGREGNLVIFVVDA FT SGSMAARDRMAAVSGATLSLLRDAYQRRDKVAVITFRQHEATLLLSPTSSAHIAGRRLA FT RFSTGGKTPLAEGLLAARALIIREKVRDRARRPLVVVLTDGRATAGPDPLGRSRTAAAG FT LVAEGAAAVVVDCETSYVRLGLAAQLARQLGAPVVRLEQLHADYLVHAVRGVA" FT CDS complement(41014..41484) FT /transl_table=11 FT /locus_tag="Rv2851c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2851c, (MTCY24A1.06), len: 156 aa. Conserved FT hypothetical protein, similar to various bacterial proteins FT e.g. Q9KP14|VC2565 ELAA PROTEIN from Vibrio cholerae (149 FT aa), FASTA scores: opt: 360, E(): 1e-18, (46.05% identity FT in 139 aa overlap); Q9I717|PA0115 HYPOTHETICAL PROTEIN from FT Pseudomonas aeruginosa (150 aa), FASTA scores: opt: 341, FT E(): 2.4e-17, (43.65% identity in 142 aa overlap); FT Q9K8M4|BH2982 HYPOTHETICAL PROTEIN from Bacillus halodurans FT (155 aa), FASTA scores: opt: 320, E(): 8e-16, (40.85% FT identity in 142 aa overlap); P52077|ELAA_ECOLI|B2267 FT PROTEIN ELAA from Escherichia coli strain K12 (153 aa), FT FASTA scores: opt: 269, E(): 3.8e-12, (35.7% identity in FT 140 aa overlap); etc." FT /db_xref="GOA:P67104" FT /db_xref="InterPro:IPR000182" FT /db_xref="UniProtKB/Swiss-Prot:P67104" FT /protein_id="CAB08455.1" FT /translation="MTEALRRVWAKDLDARALYELLKLRVEVFVVEQACPYPELDGRDL FT LAETRHFWLETPDGEVTCTLRLMEEHAGGEKVFRIGRLCTKRDARGQGHSNRLLCAALA FT EVGDYPCRIDAQAYLTAMYAQHGFVRDGDEFLDDGIPHVPMLRPGSGQVERP" FT repeat_region complement(41485..41546) FT /note="62 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT CDS complement(41543..43024) FT /transl_table=11 FT /gene="mqo" FT /locus_tag="Rv2852c" FT /product="PROBABLE MALATE:QUINONE OXIDOREDUCTASE MQO FT (MALATE DEHYDROGENASE [ACCEPTOR])" FT /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE [CATALYTIC FT ACTIVITY: (S)-MALATE + ACCEPTOR = OXALOACETATE + REDUCED FT ACCEPTOR]." FT /EC_number="1.1.99.16" FT /note="Rv2852c, (MT2918, MTCY24A1.05), len: 493 aa. FT Probable mqo, malate:quinone oxidoreductase (EC 1.1.99.16), FT highly similar to others e.g. O69282|MQO_CORGL from FT Corynebacterium glutamicum (Brevibacterium flavum) (499 FT aa), FASTA scores: opt: 1701, E(): 1.2e-101, (50.7% FT identity in 495 aa overlap); Q9Z9Q7|BH3960 from Bacillus FT halodurans (500 aa), FASTA scores: opt: 1632, E(): 3.3e-97, FT (48.55% identity in 486 aa overlap); Q9HYF4|MQOA|PA3452 FT from Pseudomonas aeruginosa (523 aa), FASTA scores: opt: FT 1604, E(): 2.1e-95, (49.1% identity in 487 aa overlap) FT (N-terminus longer); P33940|MQO_ECOLI|B2210 from FT Escherichia coli strain K12 (548 aa), FASTA scores: opt: FT 1525, E(): 2.7e-90, (48.15% identity in 492 aa overlap); FT etc. BELONGS TO THE MQO FAMILY. COFACTORS: FAD." FT /db_xref="GOA:P65419" FT /db_xref="InterPro:IPR006231" FT /db_xref="UniProtKB/Swiss-Prot:P65419" FT /protein_id="CAB08454.1" FT /translation="MSDLARTDVVLIGAGIMSATLGVLLRRLEPNWSITLIERLDAVAA FT ESSGPWNNAGTGHSALCEMNYTPEMPDGSIDITKAVRVNEQFQVTRQFWAYAAENGILT FT DVRSFLNPVPHVSFVHGSRGVEYLRRRQKALAGNPLFAGTEFIESPDEFARRLPFMAAK FT RAFSEPVALNWAADGTDVDFGALAKQLIGYCVQNGTTALFGHEVRNLSRQSDGSWTVTM FT CNRRTGEKRKLNTKFVFVGAGGDTLPVLQKSGIKEVKGFAGFPIGGRFLRAGNPALTAS FT HRAKVYGFPAPGAPPLGALHLDLRFVNGKSWLVFGPYAGWSPKFLKHGQISDLPRSIRP FT DNLLSVLGVGLTERRLLNYLISQLRLSEPERVSALREFAPSAIDSDWELTIAGQRVQVI FT RRDERNGGVLEFGTTVIGDADGSIAGLLGGSPGASTAVAIMLDVLQKCFANRYQSWLPT FT LKEMVPSLGVQLSNEPALFDEVWSWSTKALKLGAA" FT CDS 43231..45078 FT /transl_table=11 FT /gene="PE_PGRS48" FT /locus_tag="Rv2853" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2853, (MTCY24A1.04c), len: 615 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT many e.g. O53884|Rv0872c|MTV043.65c from Mycobacterium FT tuberculosis (606 aa), FASTA scores: opt: 1405, E(): FT 1.4e-97, (64.6% identity in 619 aa overlap). Equivalent to FT AAK47245 from Mycobacterium tuberculosis strain CDC1551 FT (663 aa) but shorter 48 aa." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q6MX26" FT /protein_id="CAE55525.1" FT /translation="MLYVVASPDLMTAAATNLAEIGSAISTANGAAALPTVEVVAAAAD FT EVSTQIAALFGAHARSYQTLSTQAAAFHSRFVQALTTAAASYASVEAANASPLQVALDV FT INAPAQTLLGRPLIGNGADGSTPGQAGGPGGLLYGNGGNGAAGGPNQAGGAGGNAGLIG FT NGGAGGAGGVGAVGGKRGTGGLLFGNGGAGGQGGLGLAGINGGSGGQGGHGGNAILFGQ FT GGAGGPGGTGAMGVAGTNPTPIGTAAPGSDGVNQIGNGGNTDLTGGAGGDGNAGSTTVN FT GGNGGTGGAARNSSGGTGNSFGGAGGAGGDGANGGDGGAGGEALTEGGATAVSGAGGKG FT GNAEASGGAGGNGGKGGFAQATTSVTGGNGGNGGNGHDSNAPGGAGGSGGVGGDGGRGG FT LLAGNGGTGGAGGNGGTGGAGAPGGAGGAGGKADIANSLGDNATVTGGNGGTGGDGGSA FT LGTGGAGGAGGLGGHGGAGGLLIGNGGAGGAGGLGGAGGAGGAGGEGGAGGAGGEAIPG FT GASTNSAGGDGGAGGTGGNGGDGGAGGAPGLGGAGGAGGWLIGQSGSTGGGGAGGAGGA FT GGAGGAGGSGGAGGHGDTTSGKNGSSGTAGFDGNPGQPG" FT CDS 45115..46155 FT /transl_table=11 FT /locus_tag="Rv2854" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2854, (MTCY24A1.03c), len: 346 aa. Hypothetical FT unknown protein, showing similarity with Q9CD03|ML2603 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (279 aa), FT FASTA scores: opt: 154, E(): 0.0083, (33.35% identity in 87 FT aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O05805" FT /protein_id="CAB08452.1" FT /translation="MTGWVPDVLPGYWQCTIPLGPDPDDEGDIVATLVGRGPQTGKARG FT DTTGAHHTVLAVHGYTDYFFHTELADHFANRGFAFYALDLRKCGRSRAPGQTPHFITDL FT ARYDTELEHSLSIINEQNRSAKVLVYGHSAGGLIVSLWLDRLRQRGEITRAGVTGLVLN FT SPFLDLQGPAILRLPLTSAFFAAMARMRPKWVARPPKEGGYGCTLHRDYDGEFDYNLQW FT KPVGGFPVTFGWIHASRRGHARLHRGIDVGVPNLILCSDHTVREKADPATLHRGDAVLD FT VTHITRWAGCIGNRSTVIAVADAKHDVFLSLPQPRQMAYRRLDLWLDDYLGTHNDTDAS FT ASSGKG" FT CDS 46168..47547 FT /transl_table=11 FT /gene="mtr" FT /locus_tag="Rv2855" FT /standard_name="gorA" FT /product="NADPH-DEPENDENT MYCOTHIOL REDUCTASE MTR" FT /function="INVOLVED IN REDUCTION OF MYCOTHIOL." FT /EC_number="1.-.-.-" FT /note="Rv2855, (MTCY24A1.02c), len: 459 aa. mtr, FT NADPH-dependent mycothiol reductase (EC 1.-.-.-), proven FT enzymatically but previously described as glutathione FT reductase homolog (gene name: gorA) (see citation below). FT Similar to others e.g. Q9L7K8|MERA MERCURIC REDUCTASE from FT Streptomyces sp. CHR28 (474 aa), FASTA scores: opt: 719, FT E(): 9e-38, (35.2% identity in 460 aa overlap); FT P30341|MERA_STRLI MERCURIC REDUCTASE (EC 1.16.1.1) from FT Streptomyces lividans (474 aa), FASTA scores: opt: 712, FT E(): 2.5e-37, (34.95% identity in 455 aa overlap); FT Q98ED5|MLL4296 FERRIC LEGHEMOGLOBIN REDUCTASE-2 PRECURSOR, FT DIHYDROLIPOAMIDE DEHYDROGENASE from Rhizobium loti FT (Mesorhizobium loti) (468 aa), FASTA scores: opt: 670, E(): FT 1.1e-34, (30.8% identity in 471 aa overlap); etc. BELONGS FT TO THE PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASES FT CLASS-I. COFACTOR: FAD." FT /db_xref="GOA:O07927" FT /db_xref="HSSP:1GER" FT /db_xref="InterPro:IPR017817" FT /db_xref="UniProtKB/TrEMBL:O07927" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55526.1" FT /translation="METYDIAIIGTGSGNSILDERYASKRAAICEQGTFGGTCLNVGCI FT PTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALSGEDYRRCAPN FT IDVYRTHTRFGPVQADGRYLLRTDAGEEFTAEQVVIAAGSRPVIPPAILASGVDYHTSD FT TVMRIAELPEHIVIVGSGFIAAEFAHVFSALGVRVTLVIRGSCLLRHCDDTICERFTRI FT ASTKWELRTHRNVVDGQQRGSGVALRLDDGCTINADLLLVATGRVSNADLLDAEQAGVD FT VEDGRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDTQSMIVT FT DHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAYGWAMEDTSGIVKLIT FT ERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAAEMARGQYWIHPALPEVVENALLGL FT R" FT CDS 47647..48765 FT /transl_table=11 FT /gene="nicT" FT /locus_tag="Rv2856" FT /product="POSSIBLE NICKEL-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN NICT" FT /function="SEEMS INVOLVED IN NICKEL INCORPORATION. THOUGHT FT TO BE INVOLVED IN TRANSPORT OF NICKEL ACROSS THE MEMBRANE. FT RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS FT THE MEMBRANE." FT /note="Rv2856, (MTCY24A1.01c), len: 372 aa. Possible nicT, FT nickel-transport integral membrane protein, similar to FT transport proteins and hydrogenase cluster proteins e.g. FT BAB58860|SAV2698 HYPOTHETICAL 37.9 KDA PROTEIN from FT Staphylococcus aureus subsp. aureus Mu50 (338 aa), FASTA FT scores: opt: 1082, E(): 7.1e-60, (48.05% identity in 335 aa FT overlap); Q97ZB2|HOXN HIGH-AFFINITY NICKEL-TRANSPORT FT PROTEIN from Sulfolobus solfataricus (373 aa), FASTA FT scores: opt: 922, E(): 6.6e-50, (42.2% identity in 372 aa FT overlap); P23516|HOXN_ALCEU HIGH-AFFINITY NICKEL TRANSPORT FT PROTEIN (INTEGRAL MEMBRANE PROTEIN) from Alcaligenes FT eutrophus (Ralstonia eutropha) (351 aa), FASTA scores: opt: FT 904, E(): 8.3e-49, (41.9% identity in 339 aa overlap); FT Q45247|HUPN_BRAJA HYDROGENASE NICKEL INCORPORATION PROTEIN FT from Bradyrhizobium japonicum (381 aa), FASTA scores: opt: FT 853, E(): 1.3e-45, (41.65% identity in 329 aa overlap); FT etc. SEEMS TO BELONG TO THE HOXN/HUPN/NIXA FAMILY OF NICKEL FT TRANSPORTERS (NiCoT FAMILY)." FT /db_xref="GOA:O05804" FT /db_xref="InterPro:IPR011541" FT /db_xref="UniProtKB/TrEMBL:O05804" FT /protein_id="CAB08450.1" FT /translation="MASSQLDRQRSRSAKMNRALTAAEWWRLGLMFAVIVALHLVGWLT FT VTLLVEPARLSLGGKAFGIGVGLTAYTLGLRHAFDADHIAAIDNTTRKLMSDGHRPLAV FT GFFFSLGHSTVVFGLAVMLVTGLKAIVGPVENDSSTLHHYTGLIGTSISGAFLYLIGIL FT NVIVLVGIVRVFAHLRRGDYDEAELEQQLDNRGLLIRFLGRFTKSLTKSWHMYPVGFLF FT GLGFDTATEIALLVLAGTSAAAGLPWYAILCLPVLFAAGMCLLDTIDGSFMNFAYGWAF FT SSPVRKIYYNITVTGLSVAVALLIGSVELLGLIANQLGWQGPFWDWLGGLDLNTVGFVV FT VAMFALTWAIALLVWHYGRVEERWTPAPDRTT" FT misc_feature 49086..49103 FT /note="PS00190 Cytochrome c family heme-binding site FT signature" FT CDS complement(49546..50322) FT /transl_table=11 FT /locus_tag="Rv2857c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv2857c, (MTV003.03c), len: 258 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), highly FT similar to various dehydrogenases e.g. O88068|SCI35.33c FT PROBABLE DEHYDROGENASE (SDR FAMILY) from Streptomyces FT coelicolor (260 aa), FASTA scores: opt: 1208, E(): 2e-68, FT (72.35% identity in 253 aa overlap); Q9I376|PA1649 from FT Pseudomonas aeruginosa PROBABLE SHORT-CHAIN DEHYDROGENASE FT (253 aa), FASTA scores: opt: 569, E(): 2.1e-28, (39.2% FT identity in 255 aa overlap); Q9EX74|MLHA SDR-LIKE ENZYME FT from Rhodococcus erythropolis (246 aa), FASTA scores: opt: FT 567, E(): 2.8e-28, (41.15% identity in 248 aa overlap); FT etc. Also similar to many Mycobacterium tuberculosis FT dehydrogenases e.g. FABG3|Rv2002|MT2058|MTCY39.16c PUTATIVE FT OXIDOREDUCTASE (260 aa), FASTA score: (38.3% identity in FT 248 aa overlap). BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:O33339" FT /db_xref="HSSP:1AHI" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O33339" FT /protein_id="CAA15519.1" FT /translation="MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVE FT AGGAAADELSGLFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNNAGISPPEDNLIENTE FT LAAWQRVQDVNLKSVYLCCRAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGG FT VLAMSRELGVQFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPD FT EIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL" FT CDS complement(50319..51686) FT /transl_table=11 FT /gene="aldC" FT /locus_tag="Rv2858c" FT /product="PROBABLE ALDEHYDE DEHYDROGENASE ALDC" FT /function="OXIDIZES A WIDE VARIETY OF ALDEHYDES [CATALYTIC FT ACTIVITY: ALDEHYDE + NAD(+) + H(2)O = ACID + NADH]." FT /EC_number="1.2.1.3" FT /note="Rv2858c, (MTV003.04c), len: 455 aa. Probable aldC, FT aldehyde dehydrogenase (EC 1.2.1.3), similar to many e.g. FT O88069|SCI35.34c PUTATIVE ALDEHYDE DEHYDROGENASE from FT Streptomyces coelicolor (483 aa), FASTA scores: opt: 1872, FT E(): 6.4e-109, (64.5% identity in 448 aa overlap); FT Q9FAB1|ALDH|BT-ALDH ALDEHYDE DEHYDROGENASE from Bacillus FT thermoleovorans (497 aa), FASTA scores: opt: 1157, E(): FT 2.1e-64, (44.3% identity in 458 aa overlap); O33455|CYMC FT P-CUMIC ALDEHYDE DEHYDROGENASE from Pseudomonas putida (494 FT aa), FASTA scores: opt: 1149, E(): 6.5e-64, (43.15% FT identity in 452 aa overlap); FT P40047|DHA5_YEAST|ALD5|ALDH5|ALD3|YER073W ALDEHYDE FT DEHYDROGENASE from Saccharomyces cerevisiae (Baker's yeast) FT (519 aa), FASTA scores: opt: 1091, E(): 2.7e-60, (38.55% FT identity in 459 aa overlap); FT P80668|FEAB_ECOLI|PADA|MAOB|B1385 PHENYLACETALDEHYDE FT DEHYDROGENASE (EC 1.2.1.39) from Escherichia coli strain FT K12 (499 aa), FASTA scores: opt: 1074, E(): 3e-59, (42.2% FT identity in 462 aa overlap); etc. Also similar to many M. FT tuberculosis dehydrogenases e.g. P71823|Rv0768|MTCY369.13 FT (489 aa), FASTA score: (38.1% identity in 467 aa overlap). FT Contains PS00687 Aldehyde dehydrogenases glutamic acid FT active site and PS00070 Aldehyde dehydrogenases cysteine FT active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:O33340" FT /db_xref="HSSP:1A4S" FT /db_xref="InterPro:IPR016162" FT /db_xref="UniProtKB/TrEMBL:O33340" FT /protein_id="CAA15520.1" FT /translation="MSTTQLINPATEEVLASVDHTDANAVDDAVQRARAAQRRWARLAP FT AQRAAGLRAFAAAVQAHLDELAALEVANSGHPIVSAEWEAGHVRDVLAFYAASPERLSG FT RQIPVAGGVDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTT FT MRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKRVMAGAAAQ FT VKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNAGQDCCARSRILVQRSVYDRFME FT LLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKVAGYVPDDAPVAFRGTAPAGRGFWFPP FT TVLTPKRGDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVA FT RAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEEM" FT misc_feature complement(50886..50921) FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT misc_feature complement(50982..51005) FT /note="PS00687 Aldehyde dehydrogenases glutamic acid active FT site" FT CDS complement(51683..52609) FT /transl_table=11 FT /locus_tag="Rv2859c" FT /product="POSSIBLE AMIDOTRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="6.3.5.-" FT /EC_number="2.-.-.-" FT /note="Rv2859c, (MTV003.05c), len: 308 aa. Possible FT amidotransferase (EC 6.3.5.- or 2.-.-.-), equivalent (but FT longer 58 aa) to Q9CBU9|ML1573 POSSIBLE AMIDOTRANSFERASE FT from Mycobacterium leprae (249 aa), FASTA scores: opt: FT 1226, E(): 3e-64, (71.55% identity in 239 aa overlap). Also FT similar to other amidotransferases and hypothetical FT proteins, but shorter in N-terminus e.g. O88072|SCI35.37 FT HYPOTHETICAL 25.3 KDA PROTEIN from Streptomyces coelicolor FT (242 aa), FASTA scores: opt: 683, E(): 1.2e-32, (47.65% FT identity in 235 aa overlap); AAK79730|Q97I88|CAC1764 FT PREDICTED GLUTAMINE AMIDOTRANSFERASE from Clostridium FT acetobutylicum (241 aa), FASTA scores: opt: 458, E(): FT 1.6e-19, (32.95% identity in 246 aa overlap); FT AAK75201|Q97QV9|SP1089 GLUTAMINE AMIDOTRANSFERASE CLASS I FT from Streptococcus pneumoniae (229 aa), FASTA scores: opt: FT 431, E(): 5.6e-18, (34.75% identity in 236 aa overlap); FT etc. Contains three 17 aa repeats at the N-terminus very FT similar to those in other Mycobacterium tuberculosis FT proteins e.g. Q10699|YY30_MYCTU|Rv2090|MT2151|MTCY49.30 FT PUTATIVE 5'-3' EXONUCLEASE RV2090 (EC 3.1.11.-)." FT /db_xref="GOA:O33341" FT /db_xref="InterPro:IPR011697" FT /db_xref="UniProtKB/TrEMBL:O33341" FT /protein_id="CAA15521.1" FT /translation="MDLSASRSDGGDPLRPASPRLRSPVSDGGDPLRPASPRLRSPVSD FT GGDPLRPASPRLRSPLGASRPVVGLTAYLEQVRTGVWDIPAGYLPADYFEGITMAGGVA FT VLLPPQPVDPESVGCVLDSLHALVITGGYDLDPAAYGQEPHPATDHPRPGRDAWEFALL FT RGALQRGMPVLGICRGTQVLNVALGGTLHQHLPDILGHSGHRAGNGVFTRLPVHTASGT FT RLAELIGESADVPCYHHQAIDQVGEGLVVSAVDVDGVIEALELPGDTFVLAVQWHPEKS FT LDDLRLFKALVDAASGYAGRQSQAEPR" FT repeat_region complement(52431..52481) FT /note="51 bp direct repeat 1, FT GTCCGATGGTGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC" FT repeat_region complement(52485..52535) FT /note="51 bp direct repeat 2, FT GTCCGATGGTGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC" FT repeat_region complement(52539..52579) FT /note="(41 bp) part of 51 bp direct repeat 3, FT GGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC" FT CDS complement(52590..53963) FT /transl_table=11 FT /gene="glnA4" FT /locus_tag="Rv2860c" FT /product="PROBABLE GLUTAMINE SYNTHETASE GLNA4 (GLUTAMINE FT SYNTHASE) (GS-II)" FT /function="INVOLVED IN GLUTAMINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY: ATP + L-GLUTAMATE + NH(3) = ADP + GLUTAMINE + FT ORTHOPHOSPHATE]." FT /EC_number="6.3.1.2" FT /note="Rv2860c, (MTV003.06c), len: 457 aa. Probable glnA4, FT glutamine synthetase class II (EC 6.3.1.2), similar to many FT glutamine synthases e.g. O88070|SCI35.35c from Streptomyces FT coelicolor (462 aa), FASTA scores: opt: 1947, E(): FT 8.2e-120, (64.15% identity in 452 aa overlap); FT Q98H15|MLL3074 from Rhizobium loti (Mesorhizobium loti) FT (465 aa), FASTA scores: opt: 1321, E(): 7.8e-79, (46.7% FT identity in 452 aa overlap); Q98EM0|MLL4187 from Rhizobium FT loti (Mesorhizobium loti) (456 aa), FASTA scores: opt: 698, FT E(): 4.6e-38, (33.5% identity in 454 aa overlap); FT Q9CDL9|GLNA from Lactococcus lactis (subsp. lactis) FT (Streptococcus lactis) (446 aa), FASTA scores: opt: 633, FT E(): 8.2e-34, (32.45% identity in 456 aa overlap); etc. FT Also similar to three other potential glutamine synthases FT in Mycobacterium tuberculosis: FT Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY42 FT 7. 03c PROBABLE GLUTAMINE SYNTHETASE (446 aa), FASTA score: FT (31.1% identity in 453 aa overlap); Rv1878|glnA3 and FT Rv2220|glnA1. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY." FT /db_xref="GOA:O33342" FT /db_xref="HSSP:1LGR" FT /db_xref="InterPro:IPR014746" FT /db_xref="UniProtKB/TrEMBL:O33342" FT /protein_id="CAA15522.1" FT /translation="MTGPGSPPLAWTELERLVAAGDVDTVIVAFTDMQGRLAGKRISGR FT HFVDDIATRGVECCSYLLAVDVDLNTVPGYAMASWDTGYGDMVMTPDLSTLRLIPWLPG FT TALVIADLVWADGSEVAVSPRSILRRQLDRLKARGLVADVATELEFIVFDQPYRQAWAS FT GYRGLTPASDYNIDYAILASSRMEPLLRDIRLGMAGAGLRFEAVKGECNMGQQEIGFRY FT DEALVTCDNHAIYKNGAKEIADQHGKSLTFMAKYDEREGNSCHIHVSLRGTDGSAVFAD FT SNGPHGMSSMFRSFVAGQLATLREFTLCYAPTINSYKRFADSSFAPTALAWGLDNRTCA FT LRVVGHGQNIRVECRVPGGDVNQYLAVAALIAGGLYGIERGLQLPEPCVGNAYQGADVE FT RLPVTLADAAVLFEDSALVREAFGEDVVAHYLNNARVELAAFNAAVTDWERIRGFERL" FT CDS complement(54123..54980) FT /transl_table=11 FT /gene="mapB" FT /locus_tag="Rv2861c" FT /standard_name="map" FT /product="PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) FT (PEPTIDASE M)" FT /function="REMOVES THE AMINO-TERMINAL METHIONINE FROM FT NASCENT PROTEINS [CATALYTIC ACTIVITY: L-METHIONYLPEPTIDE + FT H(2)O = L-METHIONINE + PEPTIDE]." FT /EC_number="3.4.11.18" FT /note="Rv2861c, (MT2929, MTV003.07c), len: 285 aa. Probable FT mapB (alternate gene name: map), methionine aminopeptidase FT (EC 3.4.11.18), equivalent to Q9CBU7|MAPB|ML1576 METHIONINE FT AMINOPEPTIDASE from Mycobacterium leprae (285 aa), FASTA FT scores: opt: 1729, E(): 1e-99, (89.75% identity in 283 aa FT overlap). Also highly similar to many e.g. Q9RKR2|MAP3 from FT Streptomyces coelicolor (285 aa), FASTA scores: opt: 1385, FT E(): 2e-78, (70.65% identity in 283 aa overlap); FT Q9SW64|C7A10.320|AT4G37040 from Arabidopsis thaliana FT (Mouse-ear cress) (305 aa), FASTA scores: opt: 914, E(): FT 3e-49, (50.35% identity in 286 aa overlap); FT P07906|AMPM_ECOLI|MAP|B0168|Z0178|ECS0170 from Escherichia FT coli strains K12 and O157:H7 (264 aa), FASTA scores: opt: FT 793, E(): 8.5e-42, (51.0% identity in 245 aa overlap); etc. FT BELONGS TO PEPTIDASE FAMILY M24A; ALSO KNOWN AS THE MAP FT FAMILY 1. COFACTOR: COBALT; BINDS 2 IONS PER SUBUNIT. Note FT that this gene has an N-terminal extension present in the FT human map, but not in the prokaryotic map's. An alternative FT start, with RBS, will give a protein equivalent to the FT shorter prokaryotic map's." FT /db_xref="GOA:P0A5J2" FT /db_xref="InterPro:IPR002467" FT /db_xref="PDB:1Y1N" FT /db_xref="UniProtKB/Swiss-Prot:P0A5J2" FT /protein_id="CAE55527.1" FT /translation="MPSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPE FT VIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSC FT CTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRT FT REATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQ FT PAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEI FT LTCL" FT CDS complement(55022..55606) FT /transl_table=11 FT /locus_tag="Rv2862c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2862c, (MTV003.08), len: 194 aa. Conserved FT hypothetical protein, showing some similarity with others FT e.g. Q9X8X5|SCH35.31c HYPOTHETICAL 19.6 KDA PROTEIN from FT Streptomyces coelicolor (180 aa), FASTA scores: opt: 266, FT E(): 2.2e-11, (34.65% identity in 179 aa overlap); FT Q9Z5H1|ML0169|MLCB373.19 HYPOTHETICAL 22.1 KDA PROTEIN from FT Mycobacterium leprae (200 aa), FASTA scores: opt: 195, E(): FT 2.3e-06, (30.15% identity in 189 aa overlap); etc. Also FT some similarity to FT P71544|Y966_MYCTU|Rv0966c|MT0994|MTCY10D7.08 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (230 FT aa), FASTA scores: opt: 209, E(): 2.6e-07, (31.5% identity FT in 184 aa overlap)." FT /db_xref="InterPro:IPR012551" FT /db_xref="UniProtKB/TrEMBL:O33344" FT /protein_id="CAA15524.1" FT /translation="MTETGGDMVALRVSDADRNGTMRRLHNAVALGLINIDEFEQRSSR FT VSFACTRSELDGLVGDLPRPGAIVTSAADRVELRGWAGSLKRHGEWIVPTRLALVRRLG FT SIELDLVKARFAGPVVVIELDMMFGSLEVRLPNGASASIDDVEVYVGSASDRRKDAPAE FT GTPHVVLTGRMVCGSVVIKGPRRALLRRHRG" FT CDS 55955..56335 FT /transl_table=11 FT /locus_tag="Rv2863" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2863, (MTV003.09), len: 126 aa. Conserved FT hypothetical protein, similar to hypothetical proteins from FT Mycobacterium tuberculosis e.g. FT Q50595|YI38_MYCTU|Rv1838c|MT1886|MTCY1A11.05|MTCY359.35 FT CONSERVED HYPOTHETICAL PROTEIN (131 aa), FASTA scores: opt: FT 299, E(): 6.5e-15, (39.0% identity in 123 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:O33345" FT /protein_id="CAA15525.1" FT /translation="MIFVDTNVFMYAVGRDHPLRMPAREFLEHSLEHQDRLVTSAEAMQ FT ELLNAYVPVGRNSTLDSALTLVRALTEIWPVEAADVAHARTLHHRHPGLGARDLLHLAC FT CQRRGVTRIKTFDHTLASAFRS" FT CDS complement(56417..58228) FT /transl_table=11 FT /locus_tag="Rv2864c" FT /product="POSSIBLE PENICILLIN-BINDING LIPOPROTEIN" FT /function="UNKNOWN, POSSIBLY INVOLVED IN CELL WALL FT BIOSYNTHESIS." FT /note="Rv2864c, (MTV003.10c), len: 603 aa. Possible FT penicillin-binding lipoprotein, probably located in FT periplasm, equivalent to Q9CBU6|ML1577 PROBABLE PENICILLIN FT BINDING PROTEIN from Mycobacterium leprae (608 aa), FASTA FT scores: opt: 3352, E(): 2.1e-193, (81.5% identity in 606 aa FT overlap). Also shows some similarity to others e.g. FT P72405|PCBR from Streptomyces clavuligerus (551 aa), FASTA FT scores: opt: 543, E(): 6.1e-25, (28.4% identity in 567 aa FT overlap); Q9F2L0|SCH63.18c from Streptomyces coelicolor FT (546 aa), FASTA scores: opt: 519, E(): 1.7e-23, (29.3% FT identity in 577 aa overlap); Q9RKD1|SCE87.07 from FT Streptomyces coelicolor (541 aa), FASTA scores: opt: 472, FT E(): 1.1e-20, (34.3% identity in 318 aa overlap); etc. FT Equivalent to AAK47258 from Mycobacterium tuberculosis FT strain CDC1551 (618 aa) but shorter 15 aa. Contains signal FT sequence and appropriately positioned PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site, and PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:O33346" FT /db_xref="InterPro:IPR001460" FT /db_xref="UniProtKB/TrEMBL:O33346" FT /protein_id="CAA15526.1" FT /translation="MVTKTTLASATSGLLLLAVVAMSGCTPRPQGPGPAAEKFFAALAI FT GDTASAAQLSDNPNEAREALNAAWAGLQAAHLDAQVLSAKYAEDTGTVAYRFSWHLPKD FT RIWTYDGQLKMARDEGRWHVRWTTSGLHPKLGEHQTFALRADPPRRASVNEVGGTDVLV FT PGYLYHYSLDAGQAGRELFGTAHAVVGALHPFDDTLNDPQLLAEQASSSTQPLDLVTLH FT ADDSNRVAAAIGQLPGVVITPQAELLPTDKHFAPAVLNDVKKAVVDELDGKAGWRVVSV FT NQNGVDVSVLHEVAPSPASSVSITLDRVVQNAAQHAVNTRGGKAMIVVIKPSTGEILAI FT AQNAGADADGPVATTGLYPPGSTFKMITAGAAVERDLATPETLLGCPGEIDIGHRTIPN FT YGGFDLGVVPMSRAFASSCNTTFAELSSRLPPRGLTQAARRYGIGLDYQVDGITTVTGS FT VPPTVDLAERTEDGFGQGKVLASPFGMALVAATVAAGKTPVPQLIAGRPTAVEGDATPI FT SQKMIDALRPMMRLVVTNGTAKEIAGCGEVFGKTGEAEFPGGSHSWFAGYRGDLAFASL FT IVGGGSSEYAVRMTKVMFESLPPGYLA" FT misc_feature complement(56738..56761) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(58154..58186) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 58500..58781 FT /transl_table=11 FT /locus_tag="Rv2865" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2865, (MTV003.11), len: 93 aa. Conserved FT hypothetical protein, showing weak similarity with FT P58235|YR54_SYNY3|SSR2754 HYPOTHETICAL 9.7 KDA PROTEIN from FT Synechocystis sp. strain PCC 6803 (87 aa), FASTA scores: FT opt: 134, E(): 0.007, (30.65% identity in 75 aa overlap); FT BAB58570|SAV2408 CONSERVED HYPOTHETICAL PROTEIN from FT Staphylococcus aureus subsp. aureus Mu50 (83 aa), FASTA FT scores: opt: 124, E(): 0.037, (27.5% identity in 80 aa FT overlap). Also similar to Rv1247|MTV006.19c HYPOTHETICAL FT 9.8 KDA PROTEIN from Mycobacterium tuberculosis (89 aa), FT FASTA scores: opt: 249, E(): 2.6e-11, (44.2% identity in 86 FT aa overlap)." FT /db_xref="InterPro:IPR006442" FT /db_xref="PDB:3G5O" FT /db_xref="UniProtKB/TrEMBL:O33347" FT /protein_id="CAA15527.1" FT /translation="MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEW FT ESLQETLYWLAQPGIRESIAEADADIASGRTYGEDEIRAEFGVPRRPH" FT CDS 58785..59048 FT /transl_table=11 FT /locus_tag="Rv2866" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2866, (MTV003.12), len: 87 aa. Conserved FT hypothetical protein, similar to O50461|Rv1246c|MTV006.18c FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (97 aa), FASTA scores: opt: 290, E(): 3.6e-16, FT (54.1% identity in 85 aa overlap)." FT /db_xref="InterPro:IPR007712" FT /db_xref="PDB:3G5O" FT /db_xref="UniProtKB/TrEMBL:O33348" FT /protein_id="CAA15528.1" FT /translation="MPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPL FT RRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDHRADIYRR" FT CDS complement(59421..60275) FT /transl_table=11 FT /locus_tag="Rv2867c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2867c, (MTV003.13c), len: 284 aa. Conserved FT hypothetical protein, similar to Q9KYR8|SC5H4.21 FT HYPOTHETICAL 31.3 KDA PROTEIN from Streptomyces coelicolor FT (287 aa), FASTA scores: opt: 798, E(): 2.4e-45, (47.95% FT identity in 269 aa overlap)." FT /db_xref="GOA:O33349" FT /db_xref="InterPro:IPR016794" FT /db_xref="UniProtKB/TrEMBL:O33349" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA15529.1" FT /translation="MSAPPISRLVGERQVSVVRDAAAVWRVLDDDPIESCMVAARVADH FT GIDPNAIGGELWTRRGAHESLCFAGANLIPLRGGPIDLNAFADVAMSTPRRCSSLVGRA FT DLVLPMWQRLEPVWGPARDVRDNQPLMALATHPSCAIDTGVRQVRPEELDSYLVAAVDM FT FIGEVGVDPRLGDGGRGYRRRVAGLIAAGRAWARFEHGQVIFKAEVGSQSPAVGQIQGV FT WVHPEWRGIGLGTAGTATLAAVIVGSGRIASLYVNSFNTVARAAYARVGFKEIGTFATV FT LLD" FT CDS complement(60331..61494) FT /transl_table=11 FT /gene="gcpE" FT /locus_tag="Rv2868c" FT /product="PROBABLE GCPE PROTEIN" FT /function="NOT YET KNOWN. GCPE IS AN ESSENTIAL GENE." FT /note="Rv2868c, (MTV003.14c), len: 387 aa. Probable gcpE FT protein (protein e), equivalent to Q9CBU5|GCPE|ML1581 FT HYPOTHETICAL PROTEIN GCPE from Mycobacterium leprae (392 FT aa), FASTA scores: opt: 2247, E(): 6.8e-134, (87.65% FT identity in 388 aa overlap). Highly similar to essential FT gene of unknown function from Escherichia coli and other FT prokaryotes e.g. Q9X7W2|GCPE_STRCO|SC6A5.16 GCPE PROTEIN FT HOMOLOG from Streptomyces coelicolor (384 aa), FASTA FT scores: opt: 1965, E(): 3.8e-116, (78.2% identity in 385 aa FT overlap); P54482|GCPE_BACSU GCPE PROTEIN HOMOLOG from FT Bacillus subtilis (377 aa), FASTA scores: opt: 1157, E(): FT 2.6e-65, (49.55% identity in 351 aa overlap); FT P27433|GCPE_ECOLI|B2515|Z3778|ECS3377 GCPE PROTEIN (PROTEIN FT E) from Escherichia coli strains K12 and O157:H7 (372 aa), FT FASTA scores: opt: 984, E(): 2e-54, (44.15% identity in 360 FT aa overlap); etc. BELONGS TO THE GCPE FAMILY." FT /db_xref="GOA:O33350" FT /db_xref="InterPro:IPR004588" FT /db_xref="UniProtKB/Swiss-Prot:O33350" FT /protein_id="CAA15530.1" FT /translation="MTVGLGMPQPPAPTLAPRRATRQLMVGNVGVGSDHPVSVQSMCTT FT KTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPVVADIHFQPRYIF FT AAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPIRIGVNAGSLDKRFMEKYGKAT FT PEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVAAYELLAARCDYPLHLGVTEAGP FT AFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCP FT SCGRAQVDVYTLANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIF FT VRGEVIKTVPEAQIVETLIEEAMRLAAEMGEQDPGATPSGSPIVTVS" FT CDS complement(61511..62725) FT /transl_table=11 FT /locus_tag="Rv2869c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2869c, (MTV003.15c), len: 404 aa. Probable FT conserved transmembrane protein, equivalent to FT Q9CBU4|ML1582 PROBABLE INTEGRAL MEMBRANE PROTEIN from FT Mycobacterium leprae (404 aa), FASTA scores: opt: 2250, FT E(): 1.1e-128, (82.2% identity in 404 aa overlap). Also FT weakly similar to other membrane proteins or hypothetical FT proteins e.g. Q9A710|CC1916 PUTATIVE MEMBRANE-ASSOCIATED FT ZINC METALLOPROTEASE from Caulobacter crescentus (398 aa), FT FASTA scores: opt: 368, E(): 7.8e-15, (28.1% identity in FT 427 aa overlap)." FT /db_xref="GOA:O33351" FT /db_xref="InterPro:IPR008915" FT /db_xref="UniProtKB/Swiss-Prot:O33351" FT /protein_id="CAA15531.1" FT /translation="MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGP FT TLWSTRRGETEYGVKAVPLGGFCDIAGMTPVEELDPDERDRAMYKQATWKRVAVLFAGP FT GMNLAICLVLIYAIALVWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAALAG FT IRSGDVVVKVGDTPVSSFDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNG FT QGGELQPATVGAIGVGAARVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGAL FT VRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFFLAQLNLILAAINLLPLLPFD FT GGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNP FT IRLFQ" FT CDS complement(62733..63974) FT /transl_table=11 FT /gene="dxr" FT /locus_tag="Rv2870c" FT /product="PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE FT REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) FT (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE)" FT /function="INVOLVED IN THE DEOXYXYLULOSE-5-PHOSPHATE FT PATHWAY (DXP) OF ISOPRENOID BIOSYNTHESIS (AT THE SECOND FT STEP). CATALYZES THE NADP-DEPENDENT REARRANGEMENT AND FT REDUCTION OF 1-DEOXY-D-XYLULOSE-5-PHOSPHATE (DXP) TO FT 2-C-METHYL-D- ERYTHRITOL 4-PHOSPHATE (MEP)." FT /EC_number="1.1.1.-" FT /note="Rv2870c, (MTCY274.01c, MTV003.16c), len: 413 aa. FT Probable dxr, 1-deoxy-D-xylulose 5-phosphate FT reductoisomerase (EC 1.1.1.-), equivalent to FT Q9CBU3|DXR|ML1583 1-DEOXY-D-XYLULOSE 5-PHOSPHATE FT REDUCTOISOMERASE from Mycobacterium leprae (406 aa), FASTA FT scores: opt: 2145, E(): 1e-124, (84.05% identity in 395 aa FT overlap). Also highly similar to others e.g. Q9AJD7|DXR FT from Kitasatospora griseola (Streptomyces griseolosporeus) FT (386 aa), FASTA scores: opt: 1176, E(): 5.2e-65, (56.45% FT identity in 388 aa overlap); Q9KYS1|DXR_STRCO|SC5H4.18 from FT Streptomyces coelicolor (401 aa), FASTA scores: opt: 1079, FT E(): 5.1e-59, (52.25% identity in 396 aa overlap); FT P45568|DXR|B0173 from Escherichia coli strain K12 (398 aa), FT FASTA scores: opt: 120, E(): 0.032, (52.9% identity in 34 FT aa overlap); etc. Contains PS00133 Zinc carboxypeptidases, FT zinc-binding region 2 signature. BELONGS TO THE DXR FAMILY. FT N-terminus shortened since first submission." FT /db_xref="GOA:P64012" FT /db_xref="InterPro:IPR013512" FT /db_xref="PDB:2C82" FT /db_xref="UniProtKB/Swiss-Prot:P64012" FT /protein_id="CAA98375.2" FT /translation="MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLA FT AGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNAL FT VGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRG FT GTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLE FT VIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRV FT SGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAG FT RIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAK FT PGAAGRHASTLERS" FT repeat_region 62757..62799 FT /note="(43 bp) part of 51 bp direct repeat, FT GTGTCGACCCGCTGCGCCCGGCTTCGCCGTGCTTGCGATCGCC" FT misc_feature complement(63729..63761) FT /note="PS00133 Zinc carboxypeptidases, zinc-binding region FT 2 signature" FT CDS 64101..64358 FT /transl_table=11 FT /locus_tag="Rv2871" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2871, (MTCY274.02), len: 85 aa. Conserved FT hypothetical protein (see citation below), similar to other FT CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium FT tuberculosis strains H37Rv and CDC1551 e.g. FT O50456|Rv1241|MTV006.13 (86 aa), FASTA scores: opt: 172, FT E(): 2.9e-05, (37.2% identity in 86 aa overlap); FT O53811|Rv0748|MTV041.22 (85 aa), FASTA scores: opt: 170, FT E(): 4e-05, (35.3% identity in 85 aa overlap); etc." FT /db_xref="GOA:P0A5G9" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/Swiss-Prot:P0A5G9" FT /protein_id="CAA98376.1" FT /translation="MRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQA FT AGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVSVDAVR" FT CDS 64345..64788 FT /transl_table=11 FT /locus_tag="Rv2872" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2872, (MTCY274.03), len: 147 aa. Conserved FT hypothetical protein (see citation below), similar to other FT CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium FT tuberculosis strains H37Rv and CDC1551 e.g. FT O53683|Rv0277c|MTV035.05c (142 aa), FASTA scores: opt: 357, FT E(): 1.4e-17, (41.45% identity in 140 aa overlap); FT O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 350, FT E(): 4.3e-17, (41.55% identity in 142 aa overlap); etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/Swiss-Prot:P65043" FT /protein_id="CAA98372.1" FT /translation="MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLA FT GFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAMRLRPGERHWMAFRQLASDVDANGN FT DIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL" FT CDS 64868..65530 FT /transl_table=11 FT /gene="mpt83" FT /locus_tag="Rv2873" FT /standard_name="mpb83" FT /product="CELL SURFACE LIPOPROTEIN MPT83 (LIPOPROTEIN P23)" FT /function="NOT REALLY KNOWN." FT /note="Rv2873, (MTCY274.04), len: 220 aa. mpt83 (alternate FT gene name: mpb83), cell surface lipoprotein (see citations FT below). Also similar to upstream ORF FT Q50769|MP70_MYCTU|MPT70|MPB70|Rv2875|MT2943|MTCY274.06 FT which is also known as MAJOR SECRETED IMMUNOGENIC PROTEIN FT MPT70 PRECURSOR from Mycobacterium tuberculosis (193 aa), FT FASTA scores: opt: 806, E(): 2.7e-38, (70.25% identity in FT 185 aa overlap). BELONGS TO THE MPT70 / MPT83 FAMILY. FT ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR." FT /db_xref="GOA:P0A670" FT /db_xref="InterPro:IPR000782" FT /db_xref="UniProtKB/Swiss-Prot:P0A670" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98350.1" FT /translation="MINVQAKPAAAASLAAIAIAFLAGCSSTKPVSQDTSPKPATSPAA FT PVTTAAMADPAADLIGRGCAQYAAQNPTGPGSVAGMAQDPVATAASNNPMLSTLTSALS FT GKLNPDVNLVDTLNGGEYTVFAPTNAAFDKLPAATIDQLKTDAKLLSSILTYHVIAGQA FT SPSRIDGTHQTLQGADLTVIGARDDLMVNNAGLVCGGVHTANATVYMIDTVLMPPAQ" FT CDS 65810..67897 FT /transl_table=11 FT /gene="dipZ" FT /locus_tag="Rv2874" FT /product="POSSIBLE INTEGRAL MEMBRANE C-TYPE CYTOCHROME FT BIOGENESIS PROTEIN DIPZ" FT /function="COULD BE INVOLVED IN CYTOCHROME-C BIOGENESIS." FT /note="Rv2874, (MT2942, MTCY274.05), len: 695 aa. Possible FT dipZ, cytochrome c-type biogenesis protein (see citation FT below), probable integral membrane protein, similar in part FT to others or hypothetical proteins e.g. CAC48606|SMB20213 FT CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti FT (Sinorhizobium meliloti) (627 aa), FASTA scores: opt: 844, FT E(): 7.3e-43, (32.65% identity in 643 aa overlap); FT Q9ZMH0|CCDA OR JHP0250 PUTATIVE CYTOCHROME C-TYPE FT BIOGENESIS PROTEIN from Helicobacter pylori J99 FT (Campylobacter pylori J99) (239 aa), FASTA scores: opt: FT 250, E(): 1.4e-07, (27.3% identity in 227 aa overlap); FT Q9LA04|CCDA C-TYPE CYTOCHROME BIOGENESIS PROTEIN from FT Rhodobacter capsulatus (Rhodopseudomonas capsulata) (252 FT aa), FASTA scores: opt: 245, E(): 2.9e-07, (27.85% identity FT in 244 aa overlap); etc. Also similar to FT O06393|CCSA|Rv0527|MTCY25D10.06 CYTOCHROME C-TYPE FT BIOGENESIS PROTEIN from Mycobacterium tuberculosis (259 FT aa), FASTA scores: opt: 280, E(): 2.4e-09, (29.3% identity FT in 239 aa overlap)." FT /db_xref="GOA:Q10801" FT /db_xref="InterPro:IPR012335" FT /db_xref="PDB:2HYX" FT /db_xref="UniProtKB/Swiss-Prot:Q10801" FT /protein_id="CAA98351.1" FT /translation="MVESRRAAAAASAYASRCGIAPATSQRSLATPPTISVPSGEGRCR FT CHVARGAGRDPRRRLRRRRWCGRCGYHSHLTGGEFDVNRLCQQRSRERSCQLVAVPADP FT RPKRQRITDVLTLALVGFLGGLITGISPCILPVLPVIFFSGAQSVDAAQVAKPEGAVAV FT RRKRALSATLRPYRVIGGLVLSFGMVTLLGSALLSVLHLPQDAIRWAALVALVAIGAGL FT IFPRFEQLLEKPFSRIPQKQIVTRSNGFGLGLALGVLYVPCAGPILAAIVVAGATATIG FT LGTVVLTATFALGAALPLLFFALAGQRIAERVGAFRRRQREIRIATGSVTILLAVALVF FT DLPAALQRAIPDYTASLQQQISTGTEIREQLNLGGIVNAQNAQLSNCSDGAAQLESCGT FT APDLKGITGWLNTPGNKPIDLKSLRGKVVLIDFWAYSCINCQRAIPHVVGWYQAYKDSG FT LAVIGVHTPEYAFEKVPGNVAKGAANLGISYPIALDNNYATWTNYRNRYWPAEYLIDAT FT GTVRHIKFGEGDYNVTETLVRQLLNDAKPGVKLPQPSSTTTPDLTPRAALTPETYFGVG FT KVVNYGGGGAYDEGSAVFDYPPSLAANSFALRGRWALDYQGATSDGNDAAIKLNYHAKD FT VYIVVGGTGTLTVVRDGKPATLPISGPPTTHQVVAGYRLASETLEVRPSKGLQVFSFTY FT G" FT CDS 67993..68574 FT /transl_table=11 FT /gene="mpt70" FT /locus_tag="Rv2875" FT /standard_name="mpb70" FT /product="MAJOR SECRETED IMMUNOGENIC PROTEIN MPT70" FT /function="NOT REALLY KNOWN." FT /note="Rv2875, (MTCY274.06), len: 193 aa. mpt70 (alternate FT gene name: mpb70), major secreted immunogenic protein MPT70 FT precursor (see citations below). Also similar to downstream FT ORF Q10790|MP83_MYCTU|MPT83|MPB83|Rv2873|MT2940|MTCY274.04 FT CELL SURFACE LIPOPROTEIN MPT83 PRECURSOR (LIPOPROTEIN P23) FT (220 aa), FASTA scores: opt: 806, E(): 1.2e-40, (70.25% FT identity in 185 aa overlap). BELONGS TO THE MPT70 / MPT83 FT FAMILY. GENERALLY FOUND AS A MONOMER; HOMODIMER IN CULTURE FT FLUIDS." FT /db_xref="GOA:P0A668" FT /db_xref="InterPro:IPR000782" FT /db_xref="PDB:1NYO" FT /db_xref="UniProtKB/Swiss-Prot:P0A668" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98373.1" FT /translation="MKVKNTIAATSFAAAGLAALAVAVSPPAAAGDLVGPGCAEYAAAN FT PTGPASVQGMSQDPVAVAASNNPELTTLTAALSGQLNPQVNLVDTLNSGQYTVFAPTNA FT AFSKLPASTIDELKTNSSLLTSILTYHVVAGQTSPANVVGTRQTLQGASVTVTGQGNSL FT KVGNADVVCGGVSTANATVYMIDSVLMPPA" FT CDS 68626..68940 FT /transl_table=11 FT /locus_tag="Rv2876" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2876, (MTCY274.07), len: 104 aa. Possible FT conserved transmembrane protein, equivalent (but longer 16 FT aa) to Q9CBU2|ML1584 POSSIBLE CONSERVED MEMBRANE PROTEIN FT from Mycobacterium leprae (84 aa), FASTA scores: opt: 444, FT E(): 8.3e-26, (73.85% identity in 88 aa overlap)." FT /db_xref="GOA:Q10802" FT /db_xref="UniProtKB/Swiss-Prot:Q10802" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98352.1" FT /translation="MFGQWEFDVSPTGGIAVASTEVEHFAGSQHEVDTAEVPSAAWGWS FT RIDHRTWHIVGLCIFGFLLAMLRGNHVGHVEDWFLITFAAVVLFVLARDLWGRRRGWIR FT " FT CDS complement(68971..69834) FT /transl_table=11 FT /locus_tag="Rv2877c" FT /standard_name="merT" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF FT MERCURY ACROSS THE MEMBRANE." FT /note="Rv2877c, (MTCY274.08c), len: 287 aa. Probable FT conserved integral membrane protein, Mer family possibly FT involved in transport of mercury, similar to others, and to FT the fourth protein of the mercury resistance operon of FT Streptomyces sp (or other organisms), and to putative FT cytochrome-c biogenesis proteins e.g. Q9XBD1|CZA382.20C FT PUTATIVE INTEGRAL MEMBRANE TRANSPORTER from Amycolatopsis FT orientalis (298 aa), FASTA scores: opt: 913, E(): 7.6e-46, FT (51.55% identity in 293 aa overlap); P30344|MER4_STRLI FT MERCURY RESISTANCE PROBABLE HG TRANSPORT PROTEIN from FT Streptomyces lividans (319 aa), FASTA scores: opt: 427, FT E(): 1.2e-17, (32.85% identity in 289 aa overlap); Q9M5P3 FT PUTATIVE CYTOCHROME C BIOGENESIS PROTEIN PRECURSOR from FT Arabidopsis thaliana (Mouse-ear cress) (354 aa), FASTA FT scores: opt: 229, E(): 4e-06, (29.85% identity in 221 aa FT overlap); etc. Contains PS00044 Bacterial regulatory FT proteins, lysR family signature. Note that previously known FT as merT." FT /db_xref="GOA:Q7D6F5" FT /db_xref="InterPro:IPR003834" FT /db_xref="UniProtKB/TrEMBL:Q7D6F5" FT /protein_id="CAE55528.1" FT /translation="MNEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVYGQDSAGRTGP FT LSAVGRAAAATVGMALGFLTVFGIFGALTISAATAVQRYLPYATVLIGLALIALGGWLL FT LGRGLTALTPRSLGVRWAPTVRLGSMYGYGISYAVASLSCTIGPFLAVTGAGLRGGSVV FT GSVAIYLAYVAGLTLVVGVLAVAAATASSALADRLRRILPFVNRISGALLVVVGLYVGY FT YGLYELRLIAGVGANPQDAVIAAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGAFAGTW FT FRRVRR" FT misc_feature complement(69304..69381) FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS complement(69839..70360) FT /transl_table=11 FT /gene="mpt53" FT /locus_tag="Rv2878c" FT /standard_name="dsbE" FT /product="SOLUBLE SECRETED ANTIGEN MPT53 PRECURSOR" FT /function="NOT REALLY KNOWN. DESPITE A WEAK HOMOLOGY TO FT THIOREDOXIN THIS CANNOT SERVE AS A SUBSTRATE FOR FT THIOREDOXIN REDUCTASE. FURTHERMORE IT HAS NO DISULFIDE FT REDUCING ACTIVITY." FT /note="Rv2878c, (MT2946, MTCY274.09c), len: 173 aa. mpt53, FT secreted protein (contains N-terminal signal sequence) (see FT citations below). Shows some similarity with several FT disulfide bond interchange proteins e.g. P43787|THIX_HAEIN FT THIOREDOXIN-LIKE PROTEIN HI1115 from Haemophilus influenzae FT (167 aa), FASTA scores: opt: 200, E(): 1.4e-06, (28.9% FT identity in 135 aa overlap); P52237|TIPB_PSEFL FT THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR FT (CYTOCHROME C BIOGENESIS PROTEIN TIPB) (178 aa), FASTA FT scores: opt: 184, E(): 1.8e-05, (26.3% identity in 171 aa FT overlap); etc. Also highly similar to FT O53924|DSBF|Rv1677|MTV047.12 PUTATIVE LIPOPROTEIN from FT Mycobacterium tuberculosis (182 aa), FASTA scores: opt: FT 482, E(): 5.7e-26, (52.8% identity in 142 aa overlap). FT COULD BE BELONG TO THE THIOREDOXIN FAMILY. Note that also FT previously known as dsbE." FT /db_xref="GOA:P0A618" FT /db_xref="InterPro:IPR012335" FT /db_xref="PDB:1LU4" FT /db_xref="UniProtKB/Swiss-Prot:P0A618" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98354.1" FT /translation="MSLRLVSPIKAFADGIVAVAIAVVLMFGLANTPRAVAADERLQFT FT ATTLSGAPFDGASLQGKPAVLWFWTPWCPFCNAEAPSLSQVAAANPAVTFVGIATRADV FT GAMQSFVSKYNLNFTNLNDADGVIWARYNVPWQPAFVFYRADGTSTFVNNPTAAMSQDE FT LSGRVAALTS" FT CDS complement(70546..>71115) FT /transl_table=11 FT /locus_tag="Rv2879c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2879c, (MTCY274.10c), len: 189 aa. Conserved FT hypothetical protein, similar to others e.g. C-terminus of FT Q9RVT6|DR0936 CONSERVED HYPOTHETICAL PROTEIN from FT Deinococcus radiodurans (346 aa), FASTA scores: opt: 505, FT E(): 1e-26, (46.5% identity in 185 aa overlap); FT O34617|YLON_BACSU HYPOTHETICAL 41.6 KDA PROTEIN from FT Bacillus subtilis (363 aa), FASTA scores: opt: 459, E(): FT 1.2e-24, (40.5% identity in 185 aa overlap); FT YFGB_ECOLI|P36979 hypothetical 43.1 kDa protein from FT Escherichia coli (384 aa), FASTA scores, opt: 410, E(): FT 2.8e-21, (41.7% identity in 187 aa overlap); etc. Appears FT to be a frame shift with respect to following ORF but we FT can detect no error in the cosmid sequence to account for FT this." FT /db_xref="GOA:P0A644" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/Swiss-Prot:P0A644" FT /protein_id="CAA98355.1" FT /translation="WGEPLANYARVLAAVQRITARPPSGFGISARAVTVSTVGLAPAIR FT NLADARLGVTLALSLHAPDDGLRDTLVPVNNRWRISEALDAARYYANVTGRRVSIEYAL FT IRDVNDQPWRADLLGKRLHRVLGPLAHVNLIPLNPTPGSDWDASPKPVEREFVKRVRAK FT GVSCTVRDTRGREISAACGQLAAVGG" FT CDS complement(70814..71641) FT /transl_table=11 FT /locus_tag="Rv2880c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2880c, (MTCY274.11c), len: 275 aa. Conserved FT hypothetical protein, highly similar in N-terminus to FT others e.g. O86754|SC6A9.22c HYPOTHETICAL 40.4 KDA PROTEIN FT from Streptomyces coelicolor (368 aa), FASTA scores: opt: FT 663, E(): 2.6e-33, (52.6% identity in 213 aa overlap); FT Q55880|Y098_SYNY3|SLL0098 HYPOTHETICAL 38.9 KDA PROTEIN FT from Synechocystis sp. strain PCC 6803 (350 aa), FASTA FT scores: opt: 362, E(): 7.3e-15, (38.9% identity in 162 aa FT overlap); O66732|AQ_416 HYPOTHETICAL 40.2 KDA PROTEIN from FT Aquifex aeolicus (348 aa), FASTA scores: opt: 321, E(): FT 2.4e-12, (39.75% identity in 146 aa overlap); etc. Appears FT to be a frame shift with respect to preceding ORF but we FT can detect no error in the cosmid sequence to account for FT this." FT /db_xref="GOA:P0A644" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/Swiss-Prot:P0A644" FT /protein_id="CAA98356.1" FT /translation="MVPELMFDEPRPGRPPRHLADLDAAGRASAVAELGLPAFRAKQLA FT HQYYGRLIADPRQMTDLPAAVRDRIAGAMFPNLLTASADITCDAGQTRKTLWRAVDGTM FT FESVLMRYPRRNTVCISSQAGCGMACPFCATGQGGLTRNLSTAEILEQVRAGAAALRDD FT FGDRLSNVVFMGMGGAAGQLRQGVGRSSAHYRAAAVRFRDFGPRGDGVDGGSGPCYPQP FT CRRAARRDPGAVAARPRRRVARYTSSGQQPVEDQRSARCGPVLRQCDRATGVY" FT CDS complement(71664..72584) FT /transl_table=11 FT /gene="cdsA" FT /locus_tag="Rv2881c" FT /product="PROBABLE INTEGRAL MEMBRANE PHOSPHATIDATE FT CYTIDYLYLTRANSFERASE CDSA (CDP-DIGLYCERIDE SYNTHETASE) FT (CDP-DIGLYCERIDE PYROPHOSPHORYLASE) (CDP-DIACYLGLYCEROL FT SYNTHASE) (CDS) (CTP:PHOSPHATIDATE CYTIDYLYLTRANSFERASE) FT (CDP-DAG SYNTHASE) (CDP-DG SYNTHETASE)" FT /function="INVOLVED IN THE PHOSPHOLIPID BIOSYNTHESIS FT [CATALYTIC ACTIVITY: CTP + PHOSPHATIDATE = PYROPHOSPHATE + FT CDP-DIACYLGLYCEROL]." FT /EC_number="2.7.7.41" FT /note="Rv2881c, (MTCY274.12c), len: 306 aa. Probable cdsA, FT phosphatidate cytidylyltransferase (EC 2.7.7.41), integral FT membrane protein, equivalent to Q9CBU1|CDSA_MYCLE|ML1589 FT PHOSPHATIDATE CYTIDYLYLTRANSFERASE from Mycobacterium FT leprae (312 aa), FASTA scores: opt: 1470, E(): 1.1e-84, FT (70.3% identity in 313 aa overlap). Also similar to others FT e.g. Q9KPV7|VC2255 from Vibrio cholerae (280 aa), FASTA FT scores: opt: 383, E(): 1.1e-16, (29.3% identity in 280 aa FT overlap); Q9CDT2|CDSA from Lactococcus lactis (subsp. FT lactis) (Streptococcus lactis) (267 aa), FASTA scores: opt: FT 361, E(): 2.6e-15, (29.05% identity in 265 aa overlap); FT P06466|CDSA_ECOLI|CDS|B0175|Z0186|ECS0177 from Escherichia FT coli strains K12 and O157:H7 (249 aa), FASTA scores: opt: FT 352, E(): 9.2e-15, (40.4% identity in 156 aa overlap); etc. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT BELONGS TO THE CDS FAMILY." FT /db_xref="GOA:P63758" FT /db_xref="InterPro:IPR000374" FT /db_xref="UniProtKB/Swiss-Prot:P63758" FT /protein_id="CAA98357.1" FT /translation="MTTNDAGTGNPAEQPARGAKQQPATETSRAGRDLRAAIVVGLSIG FT LVLIAVLVFVPRVWVAIVAVATLVATHEVVRRLREAGYLIPVIPLLIGGQAAVWLTWPF FT GAVGALAGFGGMVVVCMIWRLFMQDSVTRPTTGGAPSPGNYLSDVSATVFLAVWVPLFC FT SFGAMLVYPENGSGWVFCMMIAVIASDVGGYAVGVLFGKHPMVPTISPKKSWEGFAGSL FT VCGITATIITATFLVGKTPWIGALLGVLFVLTTALGDLVESQVKRDLGIKDMGRLLPGH FT GGLMDRLDGILPSAVAAWIVLTLLP" FT misc_feature complement(71865..71888) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(72607..73164) FT /transl_table=11 FT /gene="frr" FT /locus_tag="Rv2882c" FT /product="RIBOSOME RECYCLING FACTOR FRR (RIBOSOME RELEASING FT FACTOR) (RRF)" FT /function="RESPONSIBLE FOR THE RELEASE OF RIBOSOMES FROM FT MESSENGER RNA AT THE TERMINATION OF PROTEIN BIOSYNTHESIS. FT MAY INCREASE THE EFFICIENCY OF TRANSLATION BY RECYCLING FT RIBOSOMES FROM ONE ROUND OF TRANSLATION TO ANOTHER." FT /note="Rv2882c, (MTCY274.13c), len: 185 aa. Probable frr, FT ribosome recycling factor, equivalent to FT O33046|RRF_MYCLE|FRR|ML1590|MLCB250.76 RIBOSOME RECYCLING FT FACTOR from Mycobacterium leprae (185 aa), FASTA scores: FT opt: 1063, E(): 2.6e-60, (90.8% identity in 185 aa FT overlap). Also highly similar to others e.g. FT O86770|RRF_STRCO|FRR|SC6A9.40c from Streptomyces coelicolor FT (185 aa), FASTA scores: opt: 783, E(): 1.5e-42, (63.25% FT identity in 185 aa overlap); P81101|RRF_BACSU|FRR from FT Bacillus subtilis (184 aa), FASTA scores: opt: 640, E(): FT 1.7e-33, (51.65% identity in 182 aa overlap); FT P16174|RRF_ECOLI|FRR|B0172|Z0183|ECS0174 from Escherichia FT coli strains K12 and O157:H7 (185 aa), FASTA scores: opt: FT 473, E(): 1.4e-23, (40.2% identity in 184 aa overlap); etc. FT BELONGS TO THE RRF FAMILY." FT /db_xref="GOA:P66734" FT /db_xref="InterPro:IPR015998" FT /db_xref="PDB:1WQF" FT /db_xref="UniProtKB/Swiss-Prot:P66734" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98358.1" FT /translation="MIDEALFDAEEKMEKAVAVARDDLSTIRTGRANPGMFSRITIDYY FT GAATPITQLASINVPEARLVVIKPYEANQLRAIETAIRNSDLGVNPTNDGALIRVAVPQ FT LTEERRRELVKQAKHKGEEAKVSVRNIRRKAMEELHRIRKEGEAGEDEVGRAEKDLDKT FT THQYVTQIDELVKHKEGELLEV" FT repeat_region complement(73165..73217) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region complement(73218..73270) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region complement(73271..73323) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS complement(73336..74121) FT /transl_table=11 FT /gene="pyrH" FT /locus_tag="Rv2883c" FT /product="PROBABLE URIDYLATE KINASE PYRH (UK) (URIDINE FT MONOPHOSPHATE KINASE) (UMP KINASE)" FT /function="URIDINE MONOPHOSPHATE KINASE [CATALYTIC FT ACTIVITY: ATP + UMP = ADP + UDP]." FT /EC_number="2.7.4.-" FT /note="Rv2883c, (MT2951, MTCY274.14c), len: 261 aa. FT Probable pyrH, uridylate kinase (EC 2.7.4.-), equivalent to FT O33045|PYRH_MYCLE|ML1591|MLCB250.75 URIDYLATE KINASE from FT Mycobacterium leprae (279 aa), FASTA scores: opt: 1437, FT E(): 3.8e-81, (85.05% identity in 274 aa overlap). Also FT highly similar to others e.g. O69913|PYRH from Streptomyces FT coelicolor (253 aa), FASTA scores: opt: 1086, E(): 1.4e-59, FT (68.9% identity in 251 aa overlap); FT P74457|PYRH_SYNY3|SLL0144 from Synechocystis sp. strain PCC FT 6803 (260 aa), FASTA scores: opt: 851, E(): 4.1e-45, FT (55.85% identity in 231 aa overlap); FT P29464|PYRH_ECOLI|SMBA|B0171|Z0182|ECS0173 from strains K12 FT and O157:H7 (240 aa), FASTA scores: opt: 666, E(): 1.1e-35, FT (45.7% identity in 232 aa overlap); etc." FT /db_xref="GOA:P65929" FT /db_xref="InterPro:IPR015963" FT /db_xref="UniProtKB/Swiss-Prot:P65929" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98359.1" FT /translation="MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGG FT QVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFFRGAQLQQLGMERTRSDYMGMLGT FT VMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYF FT STDTTAAQRALEIGADVVLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADA FT TAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT" FT CDS 74356..75114 FT /transl_table=11 FT /locus_tag="Rv2884" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv2884, (MTCY274.15), len: 252 aa. Probable FT transcriptional regulatory protein, highly similar to FT others e.g. Q05943|GLNR_STRCO|SCD84.26c TRANSCRIPTIONAL FT REGULATORY PROTEIN from Streptomyces coelicolor (267 aa), FT FASTA scores: opt: 609, E(): 2.7e-34, (46.4% identity in FT 224 aa overlap); Q55733|SLL0396 REGULATORY COMPONENTS OF FT SENSORY TRANSDUCTION SYSTEM from Synechocystis sp. strain FT PCC 6803 (224 aa), FASTA scores: opt: 330, E(): 3e-15, FT (31.8% identity in 217 aa overlap); Q9A4S3|CC2757 FT DNA-BINDING RESPONSE REGULATOR from Caulobacter crescentus FT (223 aa), FASTA scores: opt: 311, E(): 6e-14, (30.3% FT identity in 221 aa overlap); etc. Also highly similar to FT O53830|Rv0818|MTV043.10 PUTATIVE REGULATORY PROTEIN from FT Mycobacterium tuberculosis (255 aa), FASTA scores: opt: FT 665, E(): 3.8e-38, (47.6% identity in 227 aa overlap). THE FT N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY FT COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS." FT /db_xref="GOA:Q10808" FT /db_xref="HSSP:1GXQ" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q10808" FT /protein_id="CAA98360.1" FT /translation="MPTGPTTGKWHPHEVWRYLLEVLLLTDEADLESALPELESFAQSV FT QRAPLDDPGAAKGADADVAIIDARADLAAARRVCRRLTTSAPALAVVAVVAPANFVAVD FT GDWIFDDVLLNAAGGAELQARLRLAITRRRSTLAGTLQFGDLVLHPASYTASLGDRDLG FT LTLTEFKLMNFLVQHAGRAFTRTRLMREVWGYECHGRIRTVDVHVRRLRAKLGAEHESM FT IDTVRGVGYMAVTPPQPRWIISESILNRCK" FT CDS complement(75129..76511) FT /transl_table=11 FT /locus_tag="Rv2885c" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1539." FT /note="Rv2885c, (MTCY274.16c), len: 460 aa. Probable FT transposase for IS1539. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop)." FT /db_xref="InterPro:IPR010095" FT /db_xref="UniProtKB/Swiss-Prot:Q10809" FT /protein_id="CAA98361.1" FT /translation="MMARLKVPEGWCVQAFRFTLNPTQTQAASLARHFGARRKAFNWTV FT TALKADIKAWRADGTESAKPSLRVLRKRWNTVKDQVCVNAQTGQVWWPECSKEAYADGI FT AGAVDAYWNWQSCRAGKRAGKTVGVPRFKKKGRDADRVCFTTGAMRVEPDRRHLTLPVI FT GTIRTYENTRRVERLIAKGRARVLAITVRRNGTRLDASVRVLVQRPQQRRVALPDSRVG FT VDVGVRRLATVADAEGTVLEQVPNPRPLDAALRGLRRVSRARSRCTKGSRRYCERTTEL FT SRLHRRVNDVRTHHLHVLTTRLAKTHGRIVVEGLDAAGMLRQKGLPGARARRRALSDAA FT LATPRRHLSYKTGWYGSSLVVADRWFPSSKTCHACRHVQDIGWDEKWQCDGCSITHQRD FT DNAAINLARYEEPPSVVGPVGAAVKRGADRKTGPGPAGGREARKATGHPAGEQPRDGVQ FT VK" FT repeat_region complement(75129..77395) FT /mobile_element="insertion sequence:IS1539" FT /note="IS1539, len: 2267 bp. Insertion sequence IS1539." FT misc_feature complement(76134..76157) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(76508..77395) FT /transl_table=11 FT /locus_tag="Rv2886c" FT /product="PROBABLE RESOLVASE" FT /function="PREVENTS THE COINTEGRATION OF FOREIGN DNA BEFORE FT INTEGRATION INTO THE CHROMOSOME." FT /note="Rv2886c, (MTCY274.17c), len: 295 aa. Probable FT resolvase for IS1539. Contains PS00213 Lipocalin FT signature." FT /db_xref="GOA:P65045" FT /db_xref="InterPro:IPR006119" FT /db_xref="UniProtKB/Swiss-Prot:P65045" FT /protein_id="CAA98362.1" FT /translation="MSRILTHVPGRTVNRSYALPALVGSAAGRLSGNHSHGREAYIALP FT QWACSRQPSTPPLQTPGRINALWSLRPVLPMPGRGCQLLRLGGRWLSVVCCRNGSMNLV FT VWAEGNGVARVIAYRWLRVGRLPVPARRVGRVILVDEPAGQPGRWGRTAVCARLSSADQ FT KVDLDRQVVGVTAWATAEQIPVGKVVTEVGSALYGRRRTFLTLLGDPTVRRIVMKRRDR FT LGRFGFECVQAVLAADGRELVVVDSADVDDDVVGDITEILTSICARLYGKRAAGNRAAR FT AVAAAARAGGHEAR" FT misc_feature complement(77117..77158) FT /note="PS00213 Lipocalin signature" FT CDS 77394..77813 FT /transl_table=11 FT /locus_tag="Rv2887" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv2887, (MTCY274.18), len: 139 aa. Probable FT transcriptional regulatory protein, highly similar to FT Q9EX59|SC1A4.04 PUTATIVE MARR-FAMILY TRANSCRIPTIONAL FT REGULATOR from Streptomyces coelicolor (151 aa), FASTA FT scores: opt: 354, E(): 6.6e-16, (42.95% identity in 135 aa FT overlap); and similar to others e.g. AAF97817|SLYA FT TRANSCRIPTIONAL REGULATOR SLYA from Escherichia coli strain FT EPEC 2348/69 (146 aa), FASTA scores: opt: 181, E(): 0.0001, FT (27.25% identity in 132 aa overlap); FT P55740|SLYA_ECOLI|AAG56631|B1642|Z2657|ECS2351 FT TRANSCRIPTIONAL REGULATOR SLYA from Escherichia coli FT strains K12 and O157:H7 (146 aa), FASTA scores: opt: 177, FT E(): 0.00018, (27.25% identity in 132 aa overlap) ; etc. FT Contains probable helix-turn-helix motif at aa 50-71 (Score FT 1182, +3.21 SD)." FT /db_xref="GOA:P67747" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67747" FT /protein_id="CAA98363.1" FT /translation="MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLS FT QSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAK FT RAEAVVRAADARVLARLTAPQQREFKRMLEKLGSD" FT CDS complement(77827..79248) FT /transl_table=11 FT /gene="amiC" FT /locus_tag="Rv2888c" FT /product="PROBABLE AMIDASE AMIC (AMINOHYDROLASE)" FT /function="HYDROLYZES A MONOCARBOXYLIC ACID AMIDE AND FT GENERATES A MONOCARBOXYLATE [CATALYTIC ACTIVITY: A FT MONOCARBOXYLIC ACID AMIDE + H(2)O = A MONOCARBOXYLATE + FT NH(3)]." FT /EC_number="3.5.1.4" FT /note="Rv2888c, (MTCY274.19c), len: 473 aa. Probable amiC, FT amidase (EC 3.5.1.4), equivalent to FT O33040|AMI3_MYCLE|AMIC|ML1596|MLCB250.65 PUTATIVE AMIDASE FT AMIC from Mycobacterium leprae (468 aa), FASTA scores: opt: FT 2361, E(): 4.2e-139, (76.7% identity in 468 aa overlap). FT Also similar to others e.g. Q9A8N0|CC1323 PUTATIVE FT 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE from Caulobacter FT crescentus (521 aa), FASTA scores: opt: 925, E(): 7.4e-50, FT (36.55% identity in 465 aa overlap); FT O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE (EC 3.5.1.4) from FT Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 659, FT E(): 2.2e-33, (31.1% identity in 460 aa overlap); FT Q55424|AMID_SYNY3|SLL0828 PUTATIVE AMIDASE from FT Synechocystis sp. strain PCC 6803 (506 aa), FASTA scores: FT opt: 643, E(): 2.4e-32, (30.7% identity in 466 aa overlap); FT etc. Also similar to FT O05835|AMI1_MYCTU|AMIA2|Rv2363|MT2432|MTCY27.17c PUTATIVE FT AMIDASE AMIA2 (484 aa), FASTA scores: opt: 656, E(): FT 3.6e-33, (35.9% identity in 465 aa overlap); and FT Q11056|AMI2_MYCTU|AMIB2|Rv1263|MT1301|MTCY50.19c PUTATIVE FT AMIDASE from Mycobacterium tuberculosis (462 aa), FASTA FT scores: opt: 650, E(): 8.2e-33, (33.45% identity in 472 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-poop). BELONGS TO THE AMIDASE FAMILY." FT /db_xref="GOA:P63494" FT /db_xref="InterPro:IPR000120" FT /db_xref="UniProtKB/Swiss-Prot:P63494" FT /protein_id="CAA98364.1" FT /translation="MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAV FT NPALNALAYAAFDVARDAAAMGTGQEAFFSGVPTFIKDNVDVAGQPSMHGTDAWEPYAA FT VADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRNPWNTDYTAGASSSGSGA FT LVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPSRGRLPLEPEYRRLPVGIVANGVLTR FT TVRDTAAFYREAERLWRNHQLPPVGDVTSPVKQRLRIAVVTRSVLREASPEVRQLTLKL FT AGLLEELGHRVEHVDHPPAPASFVDDFVLYWGFLALAQVRSGRRTFGRTFDPTRLDELT FT LGLARHTGRNLHRLPLAIMRLRMLRRRSVRFFGTYDVLLTPTVAEATPQVGYLAPTDYQ FT TVLDRLSSWVVFTPVQNVTGVPAISLPLAQSADGMPVGMMLSADTGREALLLELAYELE FT EARPWARIHAPNIAE" FT misc_feature complement(78874..78897) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(79255..80070) FT /transl_table=11 FT /gene="tsf" FT /locus_tag="Rv2889c" FT /product="PROBABLE ELONGATION FACTOR TSF (EF-TS)" FT /function="ASSOCIATES WITH THE EF-TU.GDP COMPLEX AND FT INDUCES THE EXCHANGE OF GDP TO GTP, IT REMAINS BOUND TO THE FT AMINOACYL-TRNA. EF-TU.GTP COMPLEX UP TO THE GTP HYDROLYSIS FT STAGE ON THE RIBOSOME." FT /note="Rv2889c, (MTCY274.20c), len: 271 aa. Probable tsf, FT elongation factor, equivalent to FT O33039|EFTS_MYCLE|TSF|ML1597|MLCB250.64 ELONGATION FACTOR FT from Mycobacterium leprae (276 aa), FASTA scores: opt: FT 1430, E(): 1.9e-80, (83.7% identity in 276 aa overlap). FT Also highly similar to others e.g. Q9X5Z9|EFTS_STRRA|TSF FT from Streptomyces ramocissimus (278 aa), FASTA scores: opt: FT 928, E(): 1.1e-49, (57.05% identity in 277 aa overlap); FT O31213|EFTS_STRCO|TSF|SC2E1.42 from Streptomyces coelicolor FT (278 aa), FASTA scores: opt: 927, E(): 1.3e-49, (56.3% FT identity in 277 aa overlap); P80700|EFTS_BACSU|TSF from FT Bacillus subtilis (292 aa), FASTA scores: opt: 650, E(): FT 1.3e-32, (43.85% identity in 276 aa overlap); etc. Contains FT PS01127 Elongation factor Ts signature 2. BELONGS TO THE FT EF-TS FAMILY." FT /db_xref="GOA:Q10788" FT /db_xref="HSSP:1EFU" FT /db_xref="InterPro:IPR000449" FT /db_xref="UniProtKB/Swiss-Prot:Q10788" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98365.1" FT /translation="MANFTAADVKRLRELTGAGMLACKNALAETDGDFDKAVEALRIKG FT AKDVGKRAERATAEGLVAAKDGALIELNCETDFVAKNAEFQTLADQVVAAAAAAKPADV FT DALKGASIGDKTVEQAIAELSAKIGEKLELRRVAIFDGTVEAYLHRRSADLPPAVGVLV FT EYRGDDAAAAHAVALQIAALRARYLSRDDVPEDIVASERRIAEETARAEGKPEQALPKI FT VEGRLNGFFKDAVLLEQASVSDNKKTVKALLDVAGVTVTRFVRFEVGQA" FT misc_feature complement(79828..79860) FT /note="PS01127 Elongation factor Ts signature 2" FT CDS complement(80082..80945) FT /transl_table=11 FT /gene="rpsB" FT /locus_tag="Rv2890c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S2 RPSB" FT /function="INVOLVED IN TRANSLATION MECHANISM." FT /note="Rv2890c, (MTCY274.21c), len: 287 aa. Probable rpsB, FT 30s ribosomal protein s2, equivalent to FT O33038|RS2_MYCLE|RPSB|ML1598|MLCB250.63 30S RIBOSOMAL FT PROTEIN S2 from Mycobacterium leprae (277 aa), FASTA FT scores: opt: 1593, E(): 2.3e-93, (91.5% identity in 270 aa FT overlap). Also highly similar to others e.g. FT O31212|RS2_STRCO|RPSB|SC2E1.41 from Streptomyces coelicolor FT (310 aa), FASTA scores: opt: 1302, E(): 6.1e-75, (70.6% FT identity in 289 aa overlap); Q9KA63|RPSB|BH2427 from FT Bacillus halodurans (244 aa), FASTA scores: opt: 991, E(): FT 2.3e-55, (59.6% identity in 255 aa overlap); FT P21464|RS2_BACSU|RPSB from Bacillus subtilis (245 aa), FT FASTA scores: opt: 959, E(): 2.4e-53, (58.55% identity in FT 246 aa overlap); etc. Contains PS00962 Ribosomal protein S2 FT signature 1. BELONGS TO THE S2P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P66537" FT /db_xref="InterPro:IPR018130" FT /db_xref="UniProtKB/Swiss-Prot:P66537" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98366.1" FT /translation="MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQ FT TLTFIDKAYEFVKETVAHGGSVLFVGTKKQAQESVAAEATRVGMPYVNQRWLGGMLTNF FT STVHKRLQRLKELEAMEQTGGFEGRTKKEILGLTREKNKLERSLGGIRDMAKVPSAIWV FT VDTNKEHIAVGEARKLGIPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTRVIASAVA FT EGLQARAGLGRADGKPEAEAAEPLAEWEQELLASATASATPSATASTTALTDAPAGATE FT PTTDAS" FT misc_feature complement(80391..80435) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(80895..80930) FT /note="PS00962 Ribosomal protein S2 signature 1" FT CDS 81229..81978 FT /transl_table=11 FT /locus_tag="Rv2891" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2891, (MTCY274.22), len: 249 aa (C-terminus FT overlaps neigbouring ORF). Conserved hypothetical protein, FT similar in N-terminus to O69910|SC2E1.40c HYPOTHETICAL 22.8 FT KDA PROTEIN from Streptomyces coelicolor (226 aa), FASTA FT scores: opt: 315, E(): 3.4e-11, (40.7% identity in 145 aa FT overlap)." FT /db_xref="InterPro:IPR016047" FT /db_xref="UniProtKB/Swiss-Prot:P65047" FT /protein_id="CAA98367.1" FT /translation="MAKSPARRCTAKVRRVLSRSVLILCWSLLGAAPAHADDSRLGWPL FT RPPPAVVRQFDAASPNWNPGHRGVDLAGRPGQPVYAAGSATVVFAGLLAGRPVVSLAHP FT GGLRTSYEPVVAQVRVGQPVSAPTVIGALAAGHPGCQAAACLHWGAMWGPASGANYVDP FT LGLLKSTPIRLKPLSSEGRTLHYRQAEPVFVNEAAAGALAGAGHRKSPKQGVFRGAAQG FT GDIVARQPPGRWVCPSSAGGPIGWHRQ" FT CDS complement(81757..82983) FT /transl_table=11 FT /gene="PPE45" FT /locus_tag="Rv2892c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2892c, (MTCY274.23c), len: 408 aa. Member of the FT Mycobacterium tuberculosis PPE family, highly similar to FT many e.g. O06386|Rv3621c|MTCY15C10.31|MTCY07H7B.01 from M. FT tuberculosis (413 aa), FASTA scores: opt: 957, E(): FT 6.2e-46, (44.7% identity in 423 aa overlap)." FT /db_xref="GOA:P0A694" FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:P0A694" FT /protein_id="CAE55529.1" FT /translation="MDFGVLPPEINSGRMYAGPGSGPMMAAAAAWDSLAAELGLAAGGY FT RLAISELTGAYWAGPAAASMVAAVTPYVAWLSATAGQAEQAGMQARAAAAAYELAFAMT FT VPPPVVVANRALLVALVATNFFGQNTPAIAATEAQYAEMWAQDAAAMYAYAGSAAIATE FT LTPFTAAPVTTSPAALAGQAAATVSSTVPPLATTAAVPQLLQQLSSTSLIPWYSALQQW FT LAENLLGLTPDNRMTIVRLLGISYFDEGLLQFEASLAQQAIPGTPGGAGDSGSSVLDSW FT GPTIFAGPRASPSVAGGGAVGGVQTPQPYWYWALDRESIGGSVSAALGKGSSAGSLSVP FT PDWAARARWANPAAWRLPGDDVTALRGTAENALLRGFPMASAGQSTGGGFVHKYGFRLA FT VMQRPPFAG" FT CDS 83383..84360 FT /transl_table=11 FT /locus_tag="Rv2893" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv2893, (MTCY274.24), len: 325 aa. Possible FT oxidoreductase (EC 1.-.-.-), showing similarity with FT various proteins and/or oxidoreductases e.g. Q9AE05|RIF11 FT eleventh protein in the rif biosynthetic gene cluster from FT Amycolatopsis mediterranei (Nocardia mediterranei) (294 FT aa), FASTA scores: opt: 270, E(): 4.8e-10, (34.5% identity FT in 313 aa overlap); O52567 REDUCTASE from Amycolatopsis FT mediterranei (Nocardia mediterranei) (153 aa), FASTA FT scores: opt: 251, E(): 5e-09, (42.4% identity in 125 aa FT overlap); Q58929|MER|MJ1534 F420-DEPENDENT FT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) FT from Methanococcus jannaschii (331 aa), FASTA scores: opt: FT 249, E(): 1.2e-08, (29.7% identity in 283 aa overlap); etc. FT Also some similarity with others proteins from FT Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. FT P71844|Rv0791c|MTCY369.35c PUTATIVE OXIDOREDUCTASE (347 FT aa), FASTA scores: opt: 264, E(): 1.3e-09, (29.05% identity FT in 272 aa overlap); and P96809|Rv0132|MTCI5.06c PUTATIVE FT OXIDOREDUCTASE (360 aa), FASTA scores: opt: 260, E(): FT 2.4e-09, (33.05% identity in 239 aa overlap)." FT /db_xref="GOA:Q10814" FT /db_xref="InterPro:IPR019923" FT /db_xref="UniProtKB/TrEMBL:Q10814" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98368.1" FT /translation="MTVASTAHHTRRLRFGLAAPLPRAGTQMRAFAQAVEAAGFDVLAF FT PDHLVPSVSPFAGATAAAMATQRLHTGTLVLNNDFRHPVDTAREAAGVATLAEGRFELG FT LGAGHRRSEYDAAGITFDSGATRVARLIESAHLIRALLDAEPVDFDGQHYRVHAEAGSL FT VAPPKVRVPLLVGGNGTEVLRLGGRIADIVGLAGISHNRDATQVRFTHFDADGLADRIA FT VVRHAAGDRFEAIELNALIQAVVCTNDRNAAAAELAATLGGITPEQVLESPFLLLGTHE FT QMAEALAARQRRFGVSYWTVFDEWAGRASAMRDIAEVIALLRYG" FT CDS complement(84357..85253) FT /transl_table=11 FT /gene="xerC" FT /locus_tag="Rv2894c" FT /product="PROBABLE INTEGRASE/RECOMBINASE XERC" FT /function="PARTICIPATES IN THE SITE-SPECIFIC RECOMBINATION. FT ACTS BY CATALYZING THE CUTTING AND REJOINING OF THE FT RECOMBINATING DNA MOLECULES. ACTS JOINTLY WITH XERD." FT /note="Rv2894c, (MTCY274.25c), len: 298 aa. Probable xerC, FT integrase/recombinase, equivalent to FT Q9CBU0|XERC|ML1600|MLCB250.62 INTEGRASE/RECOMBINASE from FT Mycobacterium leprae (297 aa), FASTA scores: opt: 1624, FT E(): 2e-97, (85.15% identity in 296 aa overlap). Also FT highly similar to others integrases/recombinases (generally FT xerC and xerD) e.g. Q9HTS4|SSS|PA5280 SITE-SPECIFIC FT RECOMBINASE from Pseudomonas aeruginosa (303 aa), FASTA FT scores: opt: 660, E(): 3.2e-35, (41.8% identity in 299 aa FT overlap); Q9HXQ6|XERD|PA3738 INTEGRASE/RECOMBINASE from FT Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 656, FT E(): 5.7e-35, (40.05% identity in 297 aa overlap); FT Q9KCP0|BH1529 INTEGRASE/RECOMBINASE from Bacillus FT halodurans (299 aa), FASTA scores: opt: 645, E(): 2.9e-34, FT (37.35% identity in 300 aa overlap); etc. Also similar to FT O33200|Rv1701|MTCI125.23 INTEGRASE/RECOMBINASE from FT Mycobacterium tuberculosis (311 aa), FASTA scores: opt: FT 646, E(): 2.6e-34, (43.1% identity in 304 aa overlap). FT BELONGS TO THE 'PHAGE' INTEGRASE FAMILY." FT /db_xref="GOA:P67628" FT /db_xref="HSSP:1A0P" FT /db_xref="InterPro:IPR011931" FT /db_xref="UniProtKB/Swiss-Prot:P67628" FT /protein_id="CAA98378.1" FT /translation="MQAILDEFDEYLALQCGRSVHTRRAYLGDLRSLFAFLADRGSSLD FT ALTLSVLRSWLAATAGAGAARTTLARRTSAVKAFTAWAVRRGLLAGDPAARLQVPKARR FT TLPAVLRQDQALRAMAAAESGAEQGDPLALRDRLIVELLYATGIRVSELCGLDVDDIDT FT GHRLVRVLGKGNKQRTVPFGQPAADALHAWLVDGRRALVTAESGHALLLGARGRRLDVR FT QARTAVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTH FT VAVARLRAVHERAHPRA" FT CDS complement(85344..86195) FT /transl_table=11 FT /gene="viuB" FT /locus_tag="Rv2895c" FT /product="POSSIBLE MYCOBACTIN UTILIZATION PROTEIN VIUB" FT /function="THOUGHT TO BE INVOLVED IN INTRACELLULAR REMOVAL FT OF IRON FROM IRON-MYCOBACTIN COMPLEX. MYCOBACTIN IS AN FT IRON-CHELATING COMPOUND INVOLVED IN THE TRANSPORT OF IRON FT FROM THE BACTERIAL ENVIRONMENT INTO THE CELL CYTOPLASM." FT /note="Rv2895c, (MT2963, MTCY274.26c), len: 283 aa. FT Possible viuB, mycobactin utilization protein, highly FT similar to Q9RJ78|SCI41.06 HYPOTHETICAL 31.5 KDA PROTEIN FT from Streptomyces coelicolor (280 aa), FASTA scores: opt: FT 639, E(): 5.1e-32, (46.3% identity in 285 aa overlap); and FT similar to other proteins e.g. Q9F641|MXCB protein of the FT biosynthetic gene cluster of the myxochelin-type iron FT chelator from Stigmatella aurantiaca (270 aa), FASTA FT scores: opt: 417, E(): 2.2e-18, (34.2% identity in 263 aa FT overlap); Q56646|VIUB_VIBCH|VC2210 VIBRIOBACTIN UTILIZATION FT PROTEIN from Vibrio cholerae (271 aa), FASTA scores: opt: FT 395, E(): 5.1e-17, (31.0% identity in 274 aa overlap); FT Q56743|VIUB_VIBVU VULNIBACTIN UTILIZATION PROTEIN V from FT Vibrio vulnificus (271 aa), FASTA scores: opt: 390, E(): FT 1e-16, (33.95% identity in 274 aa overlap); etc. Equivalent FT to AAK47289 from Mycobacterium tuberculosis strain CDC1551 FT (321 aa) but shorter 38 aa." FT /db_xref="GOA:P65049" FT /db_xref="InterPro:IPR007037" FT /db_xref="UniProtKB/Swiss-Prot:P65049" FT /protein_id="CAA98369.1" FT /translation="MAGRPLHAFEVVATRHLAPHMVRVVLGGSGFDTFVPSDFTDSYIK FT LVFVDDDVDVGRLPRPLTLDSFADLPTAKRPPVRTMTVRHVDAAAREIAVDIVLHGEHG FT VAGPWAAGAQRGQPIYLMGPGGAYAPDPAADWHLLAGDESAIPAIAAALEALPPDAIGR FT AFIEVAGPDDEIGLTAPDAVEVNWVYRGGRADLVPEDRAGDHAPLIEAVTTTAWLPGQV FT HVFIHGEAQAVMHNLRPYVRNERGVDAKWASSISGYWRRGRTEEMFRKWKKELAEAEAG FT TH" FT CDS complement(86228..87397) FT /transl_table=11 FT /locus_tag="Rv2896c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2896c, (MTCY274.27c), len: 389 aa. Conserved FT hypothetical protein, similar to others proteins e.g. FT Q9ZJ08|FIR2 from Rhodococcus fascians (293 aa), FASTA FT scores: opt: 663, E(): 3.3e-32, (43.7% identity in 286 aa FT overlap); O69892|SC2E1.21 HYPOTHETICAL 37.9 KDA PROTEIN FT from Streptomyces coelicolor (382 aa), FASTA scores: opt: FT 600, E(): 2.2e-28, (46.45% identity in 267 aa overlap); FT Q9JWZ4|DPRA|NMA0158 DPRA HOMOLOG from Neisseria FT meningitidis (serogroup A) (395 aa), FASTA scores: opt: FT 495, E(): 4.1e-22, (34.6% identity in 347 aa overlap); FT etc." FT /db_xref="GOA:Q10817" FT /db_xref="InterPro:IPR003488" FT /db_xref="UniProtKB/Swiss-Prot:Q10817" FT /protein_id="CAA98374.1" FT /translation="MIDPTARAWAYLSRVAEPPCAQLAALVRCVGPVEAADRVRRGQVG FT NELAQHTGARREIDRAADDLELLMRRGGRLITPDDDEWPVLAFAAFSGAGARARPCGHS FT PLVLWALGPARLDEVAPRAAAVVGTRAATAYGEHVAADLAAGLAERDVSVVSGGAYGID FT GAAHRAALDSEGITVAVLAGGFDIPYPAGHSALLHRIAQHGVLFTEYPPGVRPARHRFL FT TRNRLVAAVARAAVVVEAGLRSGAANTAAWARALGRVVAAVPGPVTSSASAGCHTLLRH FT GAELVTRADDIVEFVGHIGELAGDEPRPGAALDVLSEAERQVYEALPGRGAATIDEIAV FT GSGLLPAQVLGPLAILEVAGLAECRDGRWRILRAGAGQAAAKGAAARLV" FT CDS complement(87394..88905) FT /transl_table=11 FT /locus_tag="Rv2897c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2897c, (MTCY274.28c), len: 503 aa. Conserved FT hypothetical protein, possibly Mg-chelatase, highly similar FT to hypothetical proteins and chelatases e.g. Q9RTV0|DR1656 FT MG(2+) CHELATASE FAMILY PROTEIN from Deinococcus FT radiodurans (519 aa), FASTA scores: opt: 1333, E(): FT 3.6e-68, (46.55% identity in 505 aa overlap);Q55372|SLR0904 FT HYPOTHETICAL 55.1 KDA PROTEIN from Synechocystis sp. strain FT PCC 6803 (509 aa), FASTA scores: opt: 1271, E(): 1.2e-64, FT (42.65% identity in 504 aa overlap); Q9HTR4|PA5290 FT HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (497 aa), FT FASTA scores: opt: 1248, E(): 2.3e-63, (45.9% identity in FT 503 aa overlap); Q9K0Z6|COMM|NMB0405 COMPETENCE PROTEIN FT (MG-CHELATASE) from Neisseria meningitidis (serogroup B), FT FASTA scores: opt: 1229, E(): 2.8e-62, (43.2% identity in FT 509 aa overlap); etc. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /db_xref="GOA:P68909" FT /db_xref="InterPro:IPR000523" FT /db_xref="UniProtKB/Swiss-Prot:P68909" FT /protein_id="CAA98370.1" FT /translation="MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVGLPDAALQES FT RDRVRAAVTNCGNSWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQQKKPWERLENT FT LLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDVRGVRTLGQ FT LQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVEVAAAGAHHLMLTGPPGV FT GKTMLAQRLPGLLPSLSGSESLEVTAIHSVAGLLSGDTPLITRPPFVAPHHSSSVAALV FT GGGSGMARPGAVSRAHRGVLFLDECAEISLSALEALRTPLEDGEIRLARRDGVACYPAR FT FQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLDRVDLRVQMHRLRAGAFSAA FT DGESTSQVRQRVALAREAAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDR FT GLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR" FT misc_feature complement(88231..88254) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(88905..89291) FT /transl_table=11 FT /locus_tag="Rv2898c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2898c, (MTCY274.29c), len: 128 aa. Conserved FT hypothetical protein, highly similar to FT O33024|YS98_MYCLE|ML1607|MLCB250.49 HYPOTHETICAL 11.0 KDA FT PROTEIN from Mycobacterium leprae (96 aa), FASTA scores: FT opt: 318, E(): 2.3e-16, (58.35% identity in 96 aa overlap). FT Also similar to other hypothetical proteins e.g. FT O69890|YE19_STRCO|SC2E1.19 from Streptomyces coelicolor FT (130 aa), FASTA scores: opt: 253, E(): 1.7e-11, (39.65% FT identity in 121 aa overlap); Q9HVZ1|PA4424 from Pseudomonas FT aeruginosa (125 aa), FASTA scores: opt: 234, E(): 4.2e-10, FT (40.85% identity in 115 aa overlap); O86871 from FT Streptomyces lividans (85 aa), FASTA scores: opt: 224, E(): FT 1.8e-09, (46.45% identity in 84 aa overlap); etc. FT Equivalent to AAK47292 from Mycobacterium tuberculosis FT strain CDC1551 (141 aa) but shorter 13 aa." FT /db_xref="GOA:P67230" FT /db_xref="InterPro:IPR003509" FT /db_xref="UniProtKB/Swiss-Prot:P67230" FT /protein_id="CAA98371.1" FT /translation="MTTLKTMTRVQLGAMGEALAVDYLTSMGLRILNRNWRCRYGELDV FT IACDAATRTVVFVEVKTRTGDGYGGLAHAVTERKVRRLRRLAGLWLADQEERWAAVRID FT VIGVRVGPKNSGRTPELTHLQGIG" FT CDS complement(89539..90369) FT /transl_table=11 FT /gene="fdhD" FT /locus_tag="Rv2899c" FT /product="POSSIBLE FDHD PROTEIN HOMOLOG" FT /function="NECESSARY FOR FORMATE DEHYDROGENASE ACTIVITY" FT /note="Rv2899c, (MTCY274.30c), len: 276 aa. Possible fdhD FT protein homolog, highly similar to other bacterial fdhd FT protein homologs or formate dehydrogenase accessory FT proteins e.g. Q9ZBW0|FDHD_STRCO|SC4B5.08c from Streptomyces FT coelicolor (282 aa), FASTA scores: opt: 1032, E(): 3.6e-59, FT (59.0% identity in 278 aa overlap); BAB59387|TVG0258796 FT from Thermoplasma volcanium (279 aa), FASTA scores: opt: FT 536, E(): 3.4e-27, (38.65% identity in 282 aa overlap); FT Q9HL17|FDHD_THEAC|TA0423 from Thermoplasma acidophilum (282 FT aa), FASTA scores: opt: 529, E(): 9.6e-27, (38.8% identity FT in 281 aa overlap); P32177|FDHD_ECOLI FDHD PROTEIN from FT Escherichia coli strain K12 (277 aa), FASTA scores: opt: FT 297, E(): 8.6e-12, (33.35% identity in 261 aa overlap); FT etc. Contain a Pfam match to entry PF02634 FdhD/NarQ FT family. BELONGS TO THE FDHD FAMILY." FT /db_xref="GOA:P64118" FT /db_xref="InterPro:IPR003786" FT /db_xref="UniProtKB/Swiss-Prot:P64118" FT /protein_id="CAA98337.1" FT /translation="MGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTMR FT TPGSDFELVQGFLLAEGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVKPP FT DVDVTRTFYTTSSCGVCGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQKVF FT ARTGGLHAAALFGVDGAMLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSGRASF FT ELTQKALMAGIPVLAAVSAPSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT" FT CDS complement(90369..92708) FT /transl_table=11 FT /gene="fdhF" FT /locus_tag="Rv2900c" FT /product="POSSIBLE FORMATE DEHYDROGENASE H FDHF FT (FORMATE-HYDROGEN-LYASE-LINKED, SELENOCYSTEINE-CONTAINING FT POLYPEPTIDE) (FORMATE DEHYDROGENASE-H ALPHA SUBUNIT) FT (FDH-H)" FT /function="DECOMPOSES FORMIC ACID TO HYDROGEN AND CARBON FT DIOXIDE UNDER ANAEROBIC CONDITIONS IN THE ABSENCE OF FT EXOGENOUS ELECTRON ACCEPTORS [CATALYTIC ACTIVITY: FORMATE + FT NAD(+) = CO(2) + NADH]." FT /EC_number="1.2.1.2" FT /note="Rv2900c, (MTCY274.31c), len: 779 aa. Possible fdhF, FT formate dehydrogenase (EC 1.2.1.2), highly similar to FT others formate dehydrogenases and prokaryotic FT molybdopterin-containing oxidoreductases e.g. FT Q9S2J9|SC7H2.18 PUTATIVE FORMATE DEHYDROGENASE from FT Streptomyces coelicolor (759 aa), FASTA scores: opt: 3038, FT E(): 2.7e-180, (59.7% identity in 767 aa overlap); FT Q9HU08|PA5181 PROBABLE OXIDOREDUCTASE from Pseudomonas FT aeruginosa (773 aa), FASTA scores: opt: 2560, E(): FT 1.1e-150, (53.2% identity in 761 aa overlap); P78160 FT FORMATE DEHYDROGENASE A CHAIN (EC 1.2.1.2) (FRAGMENT) from FT Escherichia coli strain K12 (740 aa), FASTA scores: opt: FT 2002, E(): 3.7e-116, (43.1% identity in 733 aa overlap); FT P07658|FDHF_ECOLI|P78137|B4079 FORMATE DEHYDROGENASE from FT Escherichia coli strain K12 (715 aa), FASTA scores: opt: FT 305, E(): 5.6e-13, (25.5% identity in 748 aa overlap); etc. FT BELONGS TO THE PROKARYOTIC MOLYBDOPTERIN-CONTAINING FT OXIDOREDUCTASE FAMILY." FT /db_xref="GOA:P65408" FT /db_xref="InterPro:IPR006657" FT /db_xref="UniProtKB/Swiss-Prot:P65408" FT /protein_id="CAA98338.1" FT /translation="MYVEAVRWQRSAASRDVLADYDEQAVTVAPRKREAAGVRAVMVSL FT QRGMQQMGALRTAAALARLNQRNGFDCPGCAWPEEPGGRKLAEFCENGAKAVAEEATKR FT TVTAEFFARHSVAELSAKPEYWLSQQGRLAHPMVLRPGDDHYRPISWDAAYQLIAEQLN FT GLDSPDRAVFYTSGRTSNEAAFCYQLLVRSFGTNNLPDCSNMCHESSGAALTDSIGIGK FT GSVTIGDVEHADLIVIAGQNPGTNHPRMLSVLGKAKANGAKIIAVNPLPEAGLIRFKDP FT QKVNGVVGHGIPIADEFVQIRLGGDMALFAGLGRLLLEAEERVPGSVVDRSFVDNHCAG FT FDGYRRRTLQVGLDTVMDATGIELAQLQRVAAMLMASQRTVICWAMGLTQHAHAVATIG FT EVTNVLLLRGMIGKPGAGVCPVRGHSNVQGDRTMGIWEKMPEQFLAALDREFGITSPRA FT HGFDTVAAIRAMRDGRVSVFMGMGGNFASATPDTAVTEAALRRCALTVQVSTKLNRSHL FT VHGATALILPTLGRTDRDTRNGRKQLVSVEDSMSMVHLSRGSLHPPSDQVRSEVQIICQ FT LARALFGPGHPVPWERFADDYDTIRDAIAAVVPGCDDYNHKVRVPDGFQLPHPPRDARE FT FRTSTGKANFAVNPLQWVPVPPGRLVLQTLRSHDQYNTTIYGLDDRYRGVKGGRRVVFI FT NPADIETFGLTAGDRVDLVSEWTDGQGGLQERRAKDFLVVAYSTPVGNAAAYYPETNPL FT VPLDHTAAQSNTPVSKAIIVRLEPTA" FT CDS complement(92766..93071) FT /transl_table=11 FT /locus_tag="Rv2901c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2901c, (MTCY274.32c), len: 101 aa. Conserved FT hypothetical protein, very equivalent to FT O33023|ML1610|MLCB250.41 HYPOTHETICAL 12.3 KDA PROTEIN from FT Mycobacterium leprae (101 aa), FASTA scores: opt: 658, E(): FT 2.6e-43, (99.0% identity in 101 aa overlap). Also highly FT similar to O69889|SC2E1.18 HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor and Streptomyces lividans (102 aa), FT FASTA scores: opt: 515, E(): 2.2e-32, (75.0% identity in FT 100 aa overlap)." FT /db_xref="InterPro:IPR019592" FT /db_xref="UniProtKB/Swiss-Prot:P65051" FT /protein_id="CAA98339.1" FT /translation="MSAEDLEKYETEMELSLYREYKDIVGQFSYVVETERRFYLANSVE FT MVPRNTDGEVYFELRLADAWVWDMYRPARFVKQVRVVTFKDVNIEEVEKPELRLPE" FT CDS complement(93125..93919) FT /transl_table=11 FT /gene="rnhB" FT /locus_tag="Rv2902c" FT /product="PROBABLE RIBONUCLEASE HII PROTEIN RNHB (RNASE FT HII)" FT /function="DEGRADES THE RIBONUCLEOTIDE MOIETY ON RNA-DNA FT HYBRID MOLECULES [CATALYTIC ACTIVITY: ENDONUCLEOLYTIC FT CLEAVAGE TO 5'- PHOSPHOMONOESTER]." FT /EC_number="3.1.26.4" FT /note="Rv2902c, (MT2970, MTCY274.33c), len: 264 aa. FT Probable rnhB, ribonuclease HII (EC 3.1.26.4), equivalent FT to O33022|RNH2_MYCLE|RNHB|ML1611|MLCB250.40 RIBONUCLEASE FT HII from Mycobacterium leprae (240 aa), FASTA scores: opt: FT 1242, E(): 6.9e-72, (76.75% identity in 245 aa overlap). FT Also similar (but longer ~20 aa) to others e.g. FT Q9HXY9|RNHB|PA3642 RIBONUCLEASE HII from Pseudomonas FT aeruginosa (201 aa), FASTA scores: opt: 572, E(): 3.1e-29, FT (52.7% identity in 184 aa overlap); FT Q9PEI7|RNH2_XYLFA|RNHB|XF1041 RIBONUCLEASE HII from Xylella FT fastidiosa (234 aa), FASTA scores: opt: 556, E(): 3.6e-28, FT (50.25% identity in 185 aa overlap); FT P10442|RNH2_ECOLI|RNHB|B0183 RIBONUCLEASE HII from FT Escherichia coli strain K-12 (213 aa), FASTA scores: opt: FT 519, E(): 7.4e-26, (48.65% identity in 183 aa overlap); FT etc. BELONGS TO THE RNASE HII FAMILY. COFACTOR: MANGANESE FT (BY SIMILARITY)." FT /db_xref="GOA:Q10793" FT /db_xref="InterPro:IPR001352" FT /db_xref="UniProtKB/Swiss-Prot:Q10793" FT /protein_id="CAA98340.1" FT /translation="MTKTWPPRTVIRKSGGLRGMRTLESALHRGGLGPVAGVDEVGRGA FT CAGPLVVAACVLGPGRIASLAALDDSKKLSEQAREKLFPLICRYAVAYHVVFIPSAEVD FT RRGVHVANIEGMRRAVAGLAVRPGYVLSDGFRVPGLPMPSLPVIGGDAAAACIAAASVL FT AKVSRDRVMVALDADHPGYGFAEHKGYSTPAHSRALARLGPCPQHRYSFINVRRVASGS FT NTAEVADGQPDPRDGTAQTGEGRWSKSSHPATMRATGRAQGT" FT CDS complement(93933..94817) FT /transl_table=11 FT /gene="lepB" FT /locus_tag="Rv2903c" FT /product="PROBABLE SIGNAL PEPTIDASE I LEPB (SPASE I) FT (LEADER PEPTIDASE I)." FT /function="CLEAVAGE OF N-TERMINAL LEADER SEQUENCES FROM FT SECRETED PROTEIN PRECURSORS." FT /EC_number="3.4.21.89" FT /note="Rv2903c, (MTCY274.34c), len: 294 aa. Probable lepB, FT signal peptidase I (EC 3.4.21.89) (TYPE II MEMBRANE FT PROTEIN) (see Braunstein & Belisle 2000), equivalent to FT O33021|LEP_MYCLE|ML1612|MLCB250.39 PROBABLE SIGNAL FT PEPTIDASE I from Mycobacterium leprae (289 aa), FASTA FT scores: opt: 1335, E(): 1.8e-77, (69.75% identity in 301 aa FT overlap). Also similar to many e.g. O86869|SIPX SIGNAL FT PEPTIDASE I from Streptomyces lividans (320 aa), FASTA FT scores: opt: 474, E(): 1e-22, (43.55% identity in 248 aa FT overlap); O69884|SIP1|SIPW PUTATIVE SIGNAL PEPTIDASE I from FT Streptomyces coelicolor and Streptomyces lividans (259 aa), FT FASTA scores: opt: 226, E(): 5e-07, (36.0% identity in 214 FT aa overlap); P42668|LEP_BACLI|SIP SIGNAL PEPTIDASE I from FT Bacillus licheniformis (186 aa), FASTA scores: opt: 218, FT E(): 1.3e-06, (34.5% identity in 194 aa overlap); etc. FT Contains PS00501 Signal peptidases I serine active site,and FT PS00761 Signal peptidases I signature 3. BELONGS TO FT PEPTIDASE FAMILY S26; ALSO KNOWN AS TYPE I LEADER PEPTIDASE FT FAMILY." FT /db_xref="GOA:Q10789" FT /db_xref="HSSP:1B12" FT /db_xref="InterPro:IPR011056" FT /db_xref="UniProtKB/Swiss-Prot:Q10789" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98341.1" FT /translation="MTETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADS FT EGDSKAAKTDEPRPAKRSTLREFAVLAVIAVVLYYVMLTFVARPYLIPSESMEPTLHGC FT STCVGDRIMVDKLSYRFGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALSFIG FT FVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSE FT FGPVTVPPGRVWVMGDNRTHSADSRAHCPLLCTDDPLPGTVPVANVIGKARLIVWPPSR FT WGVVRSVNPQQGR" FT misc_feature complement(94080..94121) FT /note="PS00761 Signal peptidases I signature 3" FT misc_feature complement(94515..94538) FT /note="PS00501 Signal peptidases I serine active site" FT CDS complement(94875..95216) FT /transl_table=11 FT /gene="rplS" FT /locus_tag="Rv2904c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L19 RPLS" FT /function="THIS PROTEIN IS LOCATED AT THE 30S-50S RIBOSOMAL FT SUBUNIT INTERFACE AND MAY PLAY A ROLE IN THE STRUCTURE AND FT FUNCTION OF THE AMINOACYL-TRNA BINDING SITE." FT /note="Rv2904c, (MTCY274.35c), len: 113 aa. Probable rplS, FT 50S ribosomal protein L19, equivalent to O33020|RL19_MYCLE FT 50S RIBOSOMAL PROTEIN L19 from Mycobacterium leprae (113 FT aa), FASTA scores: opt: 702, E(): 1.4e-45, (93.8% identity FT in 113 aa overlap). Also highly similar to others e.g. FT O69883|RL19_STRCO from Streptomyces coelicolor (116 aa), FT FASTA scores: opt: 571, E(): 9.5e-36, (77.25% identity in FT 110 aa overlap); O31742|RL19_BACSU from Bacillus subtilis FT (115 aa), FASTA scores: opt: 523, E(): 3.8e-32, (72.9% FT identity in 107 aa overlap); RL19_BACST|P30529 from FT Bacillus stearothermophilus (116 aa), FASTA scores: opt: FT 518, E(): 9.1e-32, (71.7% identity in 106 aa overlap); etc. FT BELONGS TO THE L19P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66080" FT /db_xref="InterPro:IPR018257" FT /db_xref="UniProtKB/Swiss-Prot:P66080" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98342.1" FT /translation="MNRLDFVDKPSLRDDIPAFNPGDTINVHVKVIEGAKERLQVFKGV FT VIRRQGGGIRETFTVRKESYGVGVERTFPVHSPNIDHIEVVTRGDVRRAKLYYLRELRG FT KKAKIKEKR" FT CDS 95591..96535 FT /transl_table=11 FT /gene="lppW" FT /locus_tag="Rv2905" FT /product="PROBABLE CONSERVED ALANINE RICH LIPOPROTEIN LPPW" FT /function="UNKNOWN" FT /note="Rv2905, (MTCY274.36), len: 314 aa. Probable lppW, FT conserved ala-rich lipoprotein, with slight similarity to FT beta-lactamases and hypothetical proteins e.g. FT Q9S1P7|SCJ9A.23 HYPOTHETICAL 36.3 KDA PROTEIN from FT Streptomyces coelicolor (336 aa), FASTA scores: opt: 222, FT E(): 2.8e-06, (25.5% identity in 298 aa overlap); FT O69914|SC3C8.01 PUTATIVE SECRETED PROTEIN from Streptomyces FT coelicolor (302 aa), FASTA scores: opt: 201, E(): 5.1e-05, FT (24.9% identity in 257 aa overlap); P14559|BLAC_STRAL FT BETA-LACTAMASE PRECURSOR from Streptomyces albus G (314 FT aa), FASTA scores: opt: 113, E(): 3.3, (25.2% identity in FT 278 aa overlap); etc. Has signal peptide and appropriately FT positioned prokaryotic lipoprotein lipid attachment site: FT ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR (POTENTIAL)." FT /db_xref="GOA:P65304" FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/Swiss-Prot:P65304" FT /protein_id="CAA98379.1" FT /translation="MRARPLTLLTALAAVTLVVVAGCEARVEAEAYSAADRISSRPQAR FT PQPQPVELLLRAITPPRAPAASPNVGFGELPTRVRQATDEAAAMGATLSVAVLDRATGQ FT LVSNGNTQIIATASVAKLFIADDLLLAEAEGKVTLSPEDHHALDVMLQSSDDGAAERFW FT SQDGGNAVVTQVARRYGLRSTAPPSDGRWWNTISSAPDLIRYYDMLLDGSGGLPLDRAA FT VIIADLAQSTPTGIDGYPQRFGIPDGLYAEPVAVKQGWMCCIGSSWMHLSTGVIGPERR FT YIMVIESLQPADDATARATITQAVRTMFPNGRI" FT CDS complement(96628..97320) FT /transl_table=11 FT /gene="trmD" FT /locus_tag="Rv2906c" FT /product="PROBABLE TRNA (GUANINE-N1)-METHYLTRANSFERASE TRMD FT (M1G-METHYLTRANSFERASE) (TRNA [GM37] METHYLTRANSFERASE)" FT /function="SPECIFICALLY METHYLATES GUANOSIME-37 IN VARIOUS FT TRNAS [CATALYTIC ACTIVITY S-ADENOSYL-L-METHIONINE + TRNA = FT S-ADENOSYL-L-HOMOCYSTEINE + TRNA CONTAINING FT N1-METHYLGUANINE]." FT /EC_number="2.1.1.31" FT /note="Rv2906c, (MTCY274.37c), len: 230 aa. Probable trmD, FT tRNA m1G methyltransferase (EC 2.1.1.31), equivalent to FT O33017|TRMD_MYCLE from Mycobacterium leprae (238 aa), FASTA FT scores: opt: 1363, E(): 8.1e-86, (87.2% identity in 227 aa FT overlap). Also highly similar to others e.g. FT O69882|TRMD_STRCO from Streptomyces coelicolor and S. FT lividans (277 aa), FASTA scores: opt: 841, E(): 4.5e-50, FT (55.55% identity in 234 aa overlap); Q9A0B6 from FT Streptococcus pyogenes (243 aa), FASTA scores: opt: 698, FT E(): 2.5e-40, (47.6% identity in 227 aa overlap); FT P07020|TRMD_ECOLI|TRMD|B2607|Z3901|ECS3470 from Escherichia FT coli strain O157:H7 (255 aa), FASTA scores: opt: 573, E(): FT 3.8e-33, (42.1% identity in 228 aa overlap); etc. BELONGS FT TO THE RNA METHYLTRANSFERASE TRMD FAMILY." FT /db_xref="GOA:P66968" FT /db_xref="HSSP:1UAJ" FT /db_xref="InterPro:IPR002649" FT /db_xref="UniProtKB/Swiss-Prot:P66968" FT /protein_id="CAA98343.1" FT /translation="MRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDVH FT HSVDDAPYGGGPGMVMKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTTESHL FT VFACGRYEGIDQRVVQDAARRMRVEEVSIGDYVLPGGESAAVVMVEAVLRLLAGVLGNP FT ASHQDDSHSTGLDGLLEGPSYTRPASWRGLDVPEVLLSGDHARIAAWRREVSLQRTRER FT RPDLSHPD" FT CDS complement(97324..97854) FT /transl_table=11 FT /gene="rimM" FT /locus_tag="Rv2907c" FT /product="PROBABLE 16S RRNA PROCESSING PROTEIN RIMM" FT /function="ESSENTIAL FOR EFFICIENT PROCESSING OF 16S RRNA. FT PROBABLY PART OF THE 30S SUBUNIT PRIOR TO OR DURING THE FT FINAL STEP IN THE PROCESSING OF 16S FREE 30S RIBOSOMAL FT SUBUNITS. IT COULD BE SOME ACCESSORY PROTEIN NEEDED FOR FT EFFICIENT ASSEMBLY OF THE 30S SUBUNIT. RIMM IS NEEDED IN A FT STEP PRIOR TO RBFA DURING THE MATURATION OF 16S RRNA. HAS FT AFFINITY FOR FREE RIBOSOMAL 30S SUBUNITS BUT NOT FOR 70S FT RIBOSOMES." FT /note="Rv2907c, (MTCY274.38c), len: 176 aa. Probable rimM, FT 16S rRNA processing protein, equivalent to FT O33016|RIMM_MYCLE PROBABLE 16S RRNA PROCESSING protein from FT Mycobacterium leprae (179 aa), FASTA scores: opt: 797, E(): FT 2.4e-46, (73.15% identity in 175 aa overlap). Also highly FT similar to others e.g. O69881|RIMM_STRCO from Streptomyces FT coelicolor (188 aa), FASTA scores: opt: 485, E(): 2.3e-25, FT (48.85% identity in 176 aa overlap); Q9KA14|RIMM_BACHD from FT Bacillus halodurans (173 aa), FASTA scores: opt: 289, E(): FT 3.2e-12, (30.65% identity in 173 aa overlap); FT P21504|RIMM_ECOLI|RIMM|B2608 from Escherichia coli strain FT K12 (182 aa), FASTA scores: opt: 237, E(): 1e-08, (29.4% FT identity in 177 aa overlap). BELONGS TO THE RIMM FAMILY." FT /db_xref="GOA:P66653" FT /db_xref="InterPro:IPR002676" FT /db_xref="UniProtKB/Swiss-Prot:P66653" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98344.1" FT /translation="MELVVGRVVKSHGVTGEVVVEIRTDDPADRFAPGTRLRAKGPFDG FT GAEGSAVSYVIESVRQHGGRLLVRLAGVADRDAADALRGSLFVIDADDLPPIDEPDTYY FT DHQLVGLMVQTATGEGVGVVTEVVHTAAGELLAVKRDSDEVLVPFVRAIVTSVSLDDGI FT VEIDPPHGLLNLE" FT CDS complement(97868..98110) FT /transl_table=11 FT /locus_tag="Rv2908c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2908c, (MTCY274.40c), len: 80 aa. Conserved FT hypothetical protein, equivalent to O33015|YT08_MYCLE from FT Mycobacterium leprae (80 aa), FASTA scores: opt: 492, E(): FT 3.1e-29, (93.75% identity in 80 aa overlap). Also highly FT similar to others e.g. O69880|YE09_STRCO from Streptomyces FT coelicolor (79 aa), FASTA scores: opt: 356, E(): 3e-19, FT (71.6% identity in 74 aa overlap); Q9KA12|BH2482 PROTEIN FT from Bacillus halodurans (76 aa), FASTA scores: opt: 220, FT E(): 2.9e-09, (48.6% identity in 72 aa overlap); FT O31738|YLQC_BACSU HYPOTHETICAL 9.1 KDA PROTEIN from FT Bacillus subtilis (81 aa), FASTA scores: opt: 172, E(): FT 1e-05, (39.2% identity in 74 aa overlap); etc. BELONGS TO FT THE UPF0109 FAMILY." FT /db_xref="GOA:P67236" FT /db_xref="InterPro:IPR004088" FT /db_xref="UniProtKB/Swiss-Prot:P67236" FT /protein_id="CAA98345.1" FT /translation="MSAVVVDAVEHLVRGIVDNPDDVRVDLITSRRGRTVEVHVHPDDL FT GKVIGRGGRTATALRTLVAGIGGRGIRVDVVDTDQ" FT CDS complement(98118..98606) FT /transl_table=11 FT /gene="rpsP" FT /locus_tag="Rv2909c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S16 RPSP" FT /function="INVOLVED IN TRANSLATION MECHANISM." FT /note="Rv2909c, (MTCY274.41c), len: 162 aa. Probable rpsP, FT 30S ribosomal protein S16, equivalent to O33014|RS16_MYCLE FT 30S RIBOSOMAL PROTEIN S16 from Mycobacterium leprae (160 FT aa), FASTA scores: opt: 828, E(): 1.6e-39, (82.5% identity FT in 160 aa overlap). Also highly similar to others e.g. FT O69879|RS16_STRCO 30S RIBOSOMAL PROTEIN S16 from FT Streptomyces coelicolor (139 aa), FASTA scores: opt: 486, FT E(): 1.9e-20, (56.95% identity in 144 aa overlap); FT P80379|RS16_THETH 30S RIBOSOMAL PROTEIN S16 from Thermus FT Thermophilus (88 aa), FASTA scores: opt: 280, E(): 4.8e-09, FT (53.25% identity in 77 aa overlap) (C-terminus shorter); FT P21474|RS16_BACSU|RPSP 30S RIBOSOMAL PROTEIN S16 (BS17) FT from Bacillus subtilis (89 aa,), FASTA scores: opt: 258, FT E(): 8.2e-08, (42.85% identity in 91 aa overlap) FT (C-terminus shorter); etc. BELONGS TO THE S16P FAMILY OF FT RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66435" FT /db_xref="HSSP:1EMW" FT /db_xref="InterPro:IPR000307" FT /db_xref="UniProtKB/Swiss-Prot:P66435" FT /protein_id="CAA98346.1" FT /translation="MAVKIKLTRLGKIRNPQYRVAVADARTRRDGRAIEVIGRYHPKEE FT PSLIEINSERAQYWLSVGAQPTEPVLKLLKITGDWQKFKGLPGAQGRLKVAAPKPSKLE FT VFNAALAAADGGPTTEATKPKKKSPAKKAAKAAEPAPQPEQPDTPALGGEQAELTAES" FT CDS complement(98790..99233) FT /transl_table=11 FT /locus_tag="Rv2910c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2910c, (MTCY274.42c), len: 147 aa. Conserved FT hypothetical protein, showing some similarity with FT hypothetical proteins from other organisms e.g. Q9JN76|MMYY FT HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor FT (153 aa), FASTA scores: opt: 164, E(): 0.00026, (35.05% FT identity in 129 aa overlap); etc. Also some similarity with FT protein from Mycobacterium tuberculosis e.g. FT O07237|Rv0310c|MTCY63.15c (163 aa), FASTA scores: opt: 165, FT E(): 0.00023, (26.3% identity in 137 aa overlap); FT P96815|Rv0138|MTCI5.12 (167 aa), FASTA scores: opt: 132, FT E(): 0.048, (30.25% identity in 109 aa overlap); etc." FT /db_xref="UniProtKB/Swiss-Prot:P65053" FT /protein_id="CAA98347.1" FT /translation="MCAVLDRSMLSVAEISDRLEIQQLLVDYSSAIDQRRFDDLDRVFT FT PDAYIDYRALGGIDGRYPKIKQWLSQVLGNFPVYAHMLGNFSVRVDGDTASSRVICFNP FT MVFAGDRQQVLFCGLWYDDDFVRTPDGWRIIRRVETKCFQKMM" FT CDS 99302..100177 FT /transl_table=11 FT /gene="dacB2" FT /locus_tag="Rv2911" FT /standard_name="dacB" FT /product="PROBABLE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE FT DACB2 (PENICILLIN-BINDING PROTEIN) (DD-PEPTIDASE) FT (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) FT (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID FT HYDROLASE)" FT /function="INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT FINAL FT STAGES). HYDROLYZES THE BOUND D-ALANYL-D-ALANINE [CATALYTIC FT ACTIVITY: D-ALANYL-D-ALANINE + H(2)O = 2 D-ALANINE]." FT /EC_number="3.4.16.4" FT /note="Rv2911, (MTCY274.43), len: 291 aa. Probable dacB2, FT D-alanyl-D-alanine carboxypeptidase (penicillin-binding FT protein) (EC 3.4.16.4), an ala-rich protein. Highly similar FT (except in N-terminus) to Q9CCM2|ML0691 PUTATIVE FT D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium FT leprae (411 aa), FASTA scores: opt: 749, E(): 9.3e-39, FT (46.75% identity in 276 aa overlap). Also similar to FT penicillin binding proteins / D-alanyl-D-alanine FT carboxypeptidases e.g. Q9KCJ8|SC4G1.16c D-ALANYL-D-ALANINE FT CARBOXYPEPTIDASE from Streptomyces coelicolor (382 aa), FT FASTA scores: opt: 386, E(): 2.1e-16, (31.25% identity in FT 285 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING FT PROTEIN 5* PRECURSOR from Bacillus subtilis (382 aa), FASTA FT scores: opt: 384, E(): 3.6e-17, (30.7% identity in 244 aa FT overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE FT CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN 5) from FT Bacillus halodurans (395 aa), FASTA scores: opt: 359, E(): FT 9.7e-15, (30.3% identity in 241 aa overlap); FT P33364|PBP7_ECOLI|PBPG|B2134 penicillin-binding protein 7 FT precursor from Escherichia coli strain K12 (313 aa), FASTA FT scores: opt: 273, E(): 7.5e-10, (27.8% identity in 263 aa FT overlap); etc. Also similar to O53380|Rv3330|MTV016.30 FT PENICILLIN-BINDING PROTEIN from Mycobacterium tuberculosis FT (405 aa), FASTA scores: opt: 746, E(): 1.4e-38, (47.0% FT identity in 266 aa overlap). Seems to contain PF00768 FT Peptidase_S11 domain PFAM. BELONGS TO PEPTIDASE FAMILY S11; FT ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FT FAMILY. Thought to be a membrane-bound protein. Note that FT previously known as dacB." FT /db_xref="GOA:Q7D6F2" FT /db_xref="InterPro:IPR018044" FT /db_xref="PDB:2BCF" FT /db_xref="UniProtKB/TrEMBL:Q7D6F2" FT /protein_id="CAE55530.1" FT /translation="MRKLMTATAALCACAVTVSAGAAWADADVQPAGSVPIPDGPAQTW FT IVADLDSGQVLAGRDQNVAHPPASTIKVLLALVALDELDLNSTVVADVADTQAECNCVG FT VKPGRSYTARQLLDGLLLVSGNDAANTLAHMLGGQDVTVAKMNAKAATLGATSTHATTP FT SGLDGPGGSGASTAHDLVVIFRAAMANPVFAQITAEPSAMFPSDNGEQLIVNQDELLQR FT YPGAIGGKTGYTNAARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQAATLFDWGFA FT LNPQASVGSL" FT CDS complement(100237..100824) FT /transl_table=11 FT /locus_tag="Rv2912c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /function="THOUGHT TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /note="Rv2912c, (MTCY274.44c), len: 195 aa. Probable FT transcription regulatory protein, tetR family, showing FT similarity with others e.g. Q9K3V9|SCD10.17 PUTATIVE FT TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor FT (202 aa), FASTA scores: opt: 185, E(): 4.4e-05, (31.15% FT identity in 167 aa overlap); Q9KFQ0 TETR-FAMILY from FT Bacillus halodurans (185 aa), FASTA scores: opt: 164, E(): FT 0.001, (35.6% identity in 73 aa overlap); FT P17446|BETI_ECOLI|BETI|B0313 regulatory protein from FT Escherichia coli strain K12 (195 aa), FASTA scores: opt: FT 126, E(): 0.024, (24.5% identity in 196 aa overlap); etc. FT Contains possible helix-turn-helix motif at aa 33-54 (+2.71 FT SD). POSSIBLY BELONGS TO THE TETR/ACRR FAMILY." FT /db_xref="GOA:P67440" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:P67440" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98349.1" FT /translation="MARTQQQRREETVARLLQASIDTIIEVGYARASAAVITKRAGVSV FT GALFRHFETMGDFMAATAYEVLRRQLETFTKQVAEIPADRPALPAALTILRDITAGSTN FT AVLYELMVAARTDEKLKETLQNVLGQYSAKIHDAARALPGAESFPEETFPVIVALMTNV FT FDGAAIVRGVLPQPELEEQRIPMLTALLTAGL" FT CDS complement(100826..102661) FT /transl_table=11 FT /locus_tag="Rv2913c" FT /product="POSSIBLE D-AMINO ACID AMINOHYDROLASE (D-AMINO FT ACID HYDROLASE)" FT /function="HYDROLIZES SPECIFIC D-AMINO ACID." FT /EC_number="3.5.1.-" FT /note="Rv2913c, (MTCY338.01c, MTCY274.45c), len: 611 aa. FT Possible D-amino acid aminohydrolase (EC 3.5.1.-), similar FT (principally in N-terminus) to D-amino acid aminohydrolases FT e.g. Q9V2D3|NDAD|PAB0090 D-AMINOACYLASE (ASPARTATE, FT GLUTAMATE ETC) from Pyrococcus abyssi (526 aa), FASTA FT scores: opt: 336, E(): 2.2e-13, (27.55% identity in 581 aa FT overlap); P94212|NDDD_ALCXX N-ACYL-D-ASPARTATE DEACYLASE FT (EC 3.5.1.83) (N-ACYL-D-ASPARTATE AMIDOHYDROLASE) from FT Alcaligenes xylosoxydans xylosoxydans (Achromobacter FT xylosoxidans) (498 aa), FASTA scores: opt: 221, E(): FT 3.4e-06, (25.95% identity in 532 aa overlap); Q9AGH8 FT D-AMINOACYLASE (EC 3.5.1.81) from Alcaligenes faecalis (484 FT aa), FASTA scores: opt: 218, E(): 5.1e-06, (28.35% identity FT in 434 aa overlap); etc." FT /db_xref="GOA:P65530" FT /db_xref="InterPro:IPR006680" FT /db_xref="UniProtKB/Swiss-Prot:P65530" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98380.1" FT /translation="MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVV FT ATVAAGALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTTVLLG FT NCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQTWSTPAEYIEAIDALPLGPNVS FT SLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMAKLLDEALEAGMLGMSGMDAAIDKLD FT GDRFRSRALPSTFATWRERRKLISVLRHRGRILQSAPDVDNPVSALLFFLASSRIFNRR FT KGVRMSMLVSADAKSMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVF FT EEFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFHDAVIVECPD FT KSLIGKSFGAIADERGLHPLDAFLDVLVDNGERNVRWTTIVANHRPNQLNKLAAEPSVH FT MGFSDAGAHLRNMAFYNFGLRLLKRARDADRAGQPFLSIERAVYRLTGELAEWFGIGAG FT TLRQGDRADFAVIDPTHLDESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFR FT GGQFGGQFRDGYGQNVKSGRYLRAGELGAALSRSA" FT CDS complement(102730..104487) FT /transl_table=11 FT /gene="pknI" FT /locus_tag="Rv2914c" FT /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN FT KINASE I PKNI (PROTEIN KINASE I) (STPK I) (PHOSPHORYLASE B FT KINASE KINASE) (HYDROXYALKYL-PROTEIN KINASE)" FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO BE INVOLVED IN CELL FT DIVISION/DIFFERENTIATION [CATALYTIC ACTIVITY: ATP + A FT PROTEIN = ADP + A PHOSPHOPROTEIN]." FT /EC_number="2.7.1.-" FT /note="Rv2914c, (MTCY338.02c), len: 585 aa. Probable pknI, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-) FT (see citation below), ala-rich protein, highly similar to FT many in Mycobacterium tuberculosis and other bacteria e.g. FT Q9RLQ7|MBK PUTATIVE SERINE/THREONINE PROTEIN KINASE from FT Mycobacterium bovis BCG (291 aa), FASTA scores: opt: 376, FT E(): 1.1e-10, (36.95% identity in 287 aa overlap); FT P33973|PKN1_MYXXA serine/threonine-protein kinase from FT Myxococcus xanthus (693 aa), FASTA scores: opt: 286, E(): FT 5.4e-10, (29.9% identity in 374 aa overlap); FT P72003|PKNF_MYCTU|Rv1746|MT1788|MTCY28.09 PROBABLE FT SERINE/THREONINE-PROTEIN KINASE from Mycobacterium FT tuberculosis (476 aa), FASTA scores: opt: 675, E(): FT 1.7e-24, (39.75% identity in 468 aa overlap); FT Q10697|PKNJ_MYCTU|Rv2088|MT2149|MTCY49.28 PROBABLE FT SERINE/THREONINE-PROTEIN KINASE from Mycobacterium FT tuberculosis (589 aa), FASTA scores: opt: 574, E(): 1e-19, FT (34.85% identity in 479 aa overlap); etc. Equivalent to FT AAK47308 from Mycobacterium tuberculosis strain CDC1551 FT (603 aa) but shorter 18 aa. Contains Hank's kinase FT subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN FT KINASES." FT /db_xref="GOA:P65730" FT /db_xref="HSSP:1O6Y" FT /db_xref="InterPro:IPR017442" FT /db_xref="UniProtKB/Swiss-Prot:P65730" FT /protein_id="CAA98986.1" FT /translation="MALASGVTFAGYTVVRMLGCSAMGEVYLVQHPGFPGWQALKVLSP FT AMAADDEFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADR FT FPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA FT SQPSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDL FT ARLDGVLSRALATAPADRFGSCREFADAMNEQAGVAIADQSSGGVDASEVTAAAGEEAY FT VVDYPAYGWPEAVDCKEPSARAPAPAAPTPQRRGSMLQSAAGVLARRLDNFSTATKAPA FT SPTRRRPRRILVGAVAVLLLAGLFAVGIVIGRKTNTTATEVARPPTSGSAVPSAPTTTV FT AVTAPVPLDGTYRIEIQRSKQTYDYTPTPQPPDVNTWWAFRTSCTPTECLAAATMLDDN FT DHTQAKTPPVRPFLMQFGEGQWKSRPETVQFPCVGPNGSPSTQATTQLLALRPQPQGDL FT VGEMVVTVHSNECGQQGAVIRIPAVASRSGDLPPAVTVPDPATIPDTPDTTSTATLTPP FT TTTAPGPGR" FT CDS complement(104531..105643) FT /transl_table=11 FT /locus_tag="Rv2915c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2915c, (MTCY338.03c), len: 370 aa. Conserved FT hypothetical protein, posssibly XAA-PRO dipeptidase FT (prolidase) (EC 3.4.13.9), highly similar to FT CAC38796|SCI39.08c CONSERVED HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor (363 aa), FASTA scores: opt: 1341, FT E(): 5.5e-76, (56.65% identity in 362 aa overlap); and FT similar to prolidases (XAA-PRO dipeptidase) e.g. FT Q9ABC9|CC0300 PUTATIVE XAA-PRO DIPEPTIDASE from Caulobacter FT crescentus (428 aa), FASTA scores: opt: 327, E(): 7.4e-13, FT (30.2% identity in 374 aa overlap); Q97XD4 PROLIDASE from FT Sulfolobus solfataricus (396 aa), FASTA scores: opt: 271, FT E(): 2.1e-09, (30.5% identity in 354 aa overlap); Q9WX55 FT PROLIDASE from Microbacterium esteraromaticum (393 aa), FT FASTA scores: opt: 256, E(): 1.8e-08, (27.95% identity in FT 365 aa overlap); etc. Also similar to FT O53619|Rv0074|MTV030.18 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (411 aa), FASTA scores: opt: FT 243, E(): 1.2e-07, (27.5% identity in 389 aa overlap)." FT /db_xref="GOA:P68917" FT /db_xref="InterPro:IPR006680" FT /db_xref="UniProtKB/Swiss-Prot:P68917" FT /protein_id="CAA98977.1" FT /translation="MKRVDTIRPRSRAVRLHVRGLGLPDETAIQLWIVDGRISTEPVAG FT ADTVFDGGWILPGLVDAHCHVGLGKHGNVELDEAIAQAETERDVGALLLRDCGSPTDTR FT GLDDHEDLPRIIRAGRHLARPKRYIAGFAVELEDESQLPAAVAEQARRGDGWVKLVGDW FT IDRQIGDLAPLWSDDVLKAAIDTAHAQGARVTAHVFSEDALPGLINAGIDCIEHGTGLT FT DDTIALMLEHGTALVPTLINLENFPGIADAAGRYPTYAAHMRDLYARGYGRVAAAREAG FT VPVYAGTDAGSTIEHGRIADEVAALQRIGMTAHEALGAACWDARRWLGRPGLDDRASAD FT LLCYAQDPRQGPGVLQHPDLVILRGRTFGP" FT CDS complement(105671..107248) FT /transl_table=11 FT /gene="ffh" FT /locus_tag="Rv2916c" FT /product="PROBABLE SIGNAL RECOGNITION PARTICLE PROTEIN FFH FT (FIFTY-FOUR HOMOLOG) (SRP PROTEIN)" FT /function="NECESSARY FOR EFFICIENT EXPORT OF FT EXTRA-CYTOPLASMIC PROTEINS. BINDS TO THE SIGNAL SEQUENCE FT WHEN IT EMERGES FROM THE RIBOSOMES." FT /note="Rv2916c, (MTCY338.04c), len: 525 aa. Probable ffh, FT signal recognition particle (SRP) protein (ala-, gly-, FT leu-rich protein) (see citation below), equivalent to FT O33013|SR54_MYCLE SIGNAL RECOGNITION PARTICLE from FT Mycobacterium leprae (521 aa), FASTA scores: opt: 2968, FT E(): 1.6e-145, (87.85% identity in 526 aa overlap). Also FT highly similar to others e.g. O69874|FFH from Streptomyces FT coelicolor (550 aa), FASTA scores: opt: 2025, E(): 6e-97, FT (63.8% identity in 519 aa overlap) (N-terminus longer 34 FT aa); P37105|SR54_BACSU from Bacillus subtilis (446 aa), FT FASTA scores: opt: 1451, E(): 1.9e-67, (51.5% identity in FT 435 aa overlap); BAB57399|FFH from Staphylococcus aureus FT subsp. aureus Mu50 (455 aa), FASTA scores: opt: 1418, E(): FT 9.4e-66, (48.65% identity in 448 aa overlap); etc. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO FT THE SRP FAMILY OF GTP-BINDING PROTEINS. NOTE THAT SIGNAL FT RECOGNITION PARTICLE CONSISTS OF A SMALL CYTOPLASMIC RNA FT (SC-RNA) MOLECULE AND PROTEIN FFH. THE PROTEIN HAS A TWO FT DOMAIN STRUCTURE: THE G-DOMAIN BINDS GTP; THE M-DOMAIN FT BINDS THE RNA AND ALSO BINDS THE SIGNAL SEQUENCE." FT /db_xref="GOA:P66844" FT /db_xref="HSSP:2FFH" FT /db_xref="InterPro:IPR004125" FT /db_xref="UniProtKB/Swiss-Prot:P66844" FT /protein_id="CAA98978.1" FT /translation="MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSL FT PVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVM FT LAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHP FT GASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDE FT VLFVLDAMIGQDAVTTAAAFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFAST FT GEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFL FT EQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIIN FT ASRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGK FT SGKKSKKGTRGPTPPKVKSPFGVPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLS FT KLKFPGKK" FT misc_feature complement(106907..106930) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 107326..109206 FT /transl_table=11 FT /locus_tag="Rv2917" FT /product="CONSERVED HYPOTHETICAL ALANINE AND ARGININE RICH FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv2917, (MTCY338.05), len: 626 aa. Conserved FT hypothetical ala-, arg-rich protein, highly similar (but FT longer 34 aa) to O33011|ML1624|MLCB250.18C HYPOTHETICAL FT 65.2 KDA PROTEIN from Mycobacterium leprae (596 aa), FASTA FT scores: opt: 3117, E(): 9e-183, (79.8% identity in 584 aa FT overlap). Also highly similar to Q9S2E8|SCE19A.36C FT HYPOTHETICAL 66.2 KDA PROTEIN from Streptomyces coelicolor FT (598 aa), FASTA scores: opt: 1921, E(): 1.1e-109, (56.08% FT identity in 567 aa overlap); and Q9S3Y6|SDRA SDRA PROTEIN FT from Streptomyces coelicolor (597 aa), FASTA scores: opt: FT 1896, E(): 3.6e-108, (55.75% identity in 567 aa overlap). FT And shows some similarity with others proteins from other FT organisms. Equivalent to AAK47311 putative RNA helicase FT from Mycobacterium tuberculosis strain CDC1551 (602 aa) but FT longer 24 aa. Contains PS00017 ATP/GTP-binding site motif FT (P-loop)." FT /db_xref="GOA:Q10966" FT /db_xref="InterPro:IPR006935" FT /db_xref="UniProtKB/Swiss-Prot:Q10966" FT /protein_id="CAA98979.1" FT /translation="MRVTRLVDAESTRCDVGPAPKSVAMLHFTAATSRFRLGRERANSV FT RSDGGWGVLQPVSATFNPPLRGWQRRALVQYLGTQPRDFLAVATPGSGKTSFALRIAAE FT LLRYHTVEQVTVVVPTEHLKVQWAHAAAAHGLSLDPKFANSNPQTSPEYHGVMVTYAQV FT ASHPTLHRVRTEARKTLVVFDEIHHGGDAKTWGDAIREAFGDATRRLALTGTPFRSDDS FT PIPFVSYQPDADGVLRSQADHTYGYAEALADGVVRPVVFLAYSGQARWRDSAGEEYEAR FT LGEPLSAEQTARAWRTALDPEGEWMPAVITAADRRLRQLRAHVPDAGGMIIASDRTTAR FT AYARLLTTMTAEEPTVVLSDDPGSSARITEFAQGTSRWLVAVRMVSEGVDVPRLSVGVY FT ATNASTPLFFAQAIGRFVRSRRPGETASIFVPSVPNLLQLASALEVQRNHVLGRPHRES FT AHDPLDGDPATRTQTERGGAERGFTALGADAELDQVIFDGSSFGTATPTGSDEEADYLG FT IPGLLDAEQMRALLHRRQDEQLRKRAQLQKGATQPATSGASASVHGQLRDLRRELHTLV FT SIAHHRTGKPHGWIHDERRRRCGGPPIAAATRAQIKARIDALRQLNSERS" FT misc_feature 107587..107610 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(109217..111643) FT /transl_table=11 FT /gene="glnD" FT /locus_tag="Rv2918c" FT /product="PROBABLE [PROTEIN-PII] URIDYLYLTRANSFERASE GLND FT (PII URIDYLYL-TRANSFERASE) (URIDYLYL REMOVING ENZYME) FT (UTASE)" FT /function="MODIFIES, BY URIDYLYLATION OR DEURIDYLYLATION FT THE PII (GLNB|Rv2919c) REGULATORY PROTEIN [CATALYTIC FT ACTIVITY: UTP + [PROTEIN-PII] = DIPHOSPHATE + FT URIDYLYL-[PROTEIN-PII]]." FT /EC_number="2.7.7.59" FT /note="Rv2918c, (MTCY338.07c), len: 808 aa. Probable glnD, FT uridylyltransferase (ala-rich protein) (EC 2.7.7.59), FT similar to other uridylyltransferases e.g. O69873||SC2E1.02 FT from Streptomyces coelicolor (835 aa), FASTA scores: opt: FT 1473, E(): 2.8e-81, (41.03% identity in 858 aa overlap); FT P43919|GLND_HAEIN from Haemophilus influenzae (863 aa), FT FASTA scores: opt: 333, E(): 2.5e-12, (25.4% identity in FT 819 aa overlap); P27249|GLND_ECOLI|GLND|B0167 from FT Escherichia coli strain K12 (890 aa), FASTA scores: opt: FT 306, E(): 1.1e-10, (27.75% identity in 858 aa overlap); FT etc. BELONGS TO THE GLND FAMILY." FT /db_xref="GOA:Q10961" FT /db_xref="InterPro:IPR013546" FT /db_xref="UniProtKB/Swiss-Prot:Q10961" FT /protein_id="CAA98971.1" FT /translation="MEAESPCAASDLAVARRELLSGNHRELDPVGLRQTWLDLHESWLI FT DKADEIGIADASGFAIVGVGGLGRRELLPYSDLDVLLLHDGKPADILRPVADRLWYPLW FT DANIRLDHSVRTVSEALTIANSDLMAALGMLEARHIAGDQQLSFALIDGVRRQWRNGIR FT SRMGELVEMTYARWRRCGRIAQRAEPDLKLGRGGLRDVQLLDALALAQLIDRHGIGHTD FT LPAGSLDGAYRTLLDVRTELHRVSGRGRDHLLAQFADEISAALGFGDRFDLARTLSSAG FT RTIGYHAEAGLRTAANALPRRGISALVRRPKRRPLDEGVVEYAGEIVLARDAEPEHDPG FT LVLRVAAASADTGLPIGAATLSRLAASVPDLPTPWPQEALDDLLVVLSAGPTTVATIEA FT LDRTGLWGRLLPEWEPIRDLPPRDVAHKWTVDRHVVETAVHAAPLATRVARPDLLALGA FT LLHDIGKGRGTDHSVLGAELVIPVCTRLGLSPPDVRTLSKLVRHHLLLPITATRRDLND FT PKTIEAVSEALGGDPQLLEVLHALSEADSKATGPGVWSDWKASLVDDLVRRCRMVMAGE FT SLPQAEPTAPHYLSLAADHGVHVEISPRDGERIDAVIVAPDERGLVSKAAAVLALNSLR FT VHSASVNVHQGVAITEFVVSPLFGSPPAAELVRQQFVGALNGDVDVLGMLQKRDSDAAS FT LVSARAGDVQAGVPVTRTAAPPRILWLDTAAPAKLILEVRAMDRAGLLALLAGALEGAG FT AGIVWAKVNTFGSTAADVFCVTVPAELDARAAVEQHLLEVLGASVDVVVDEPVGD" FT CDS complement(111701..112039) FT /transl_table=11 FT /gene="glnB" FT /locus_tag="Rv2919c" FT /product="PROBABLE NITROGEN REGULATORY PROTEIN P-II GLNB" FT /function="IN NITROGEN-LIMITING CONDITIONS, WHEN THE RATIO FT OF GLN TO 2-KETOGLUTARATE DECREASES, P-II IS URIDYLYLATED FT TO P-II-UMP BY GLND|Rv2918c. P-II-UMP ALLOWS THE FT DEADENYLYLATION OF GLUTAMINE SYNTHETASE (GS), THUS FT ACTIVATING THE ENZYME. CONVERSERLY, IN NITROGEN EXCESS P-II FT IS DEURIDYLATED AND PROMOTES THE ADENYLATION OF GS. P-II FT INDIRECTLY CONTROLS THE TRANSCRIPTION OF THE GS GENE (GLNA: FT FOUR COPIES IN THE GENOME). P-II PREVENTS NR-II CATALYZED FT CONVERSION OF NR-I TO NR-I-PHOSPHATE, THE TRANSCRIPTIONAL FT ACTIVATOR OF GLNA. WHEN P-II IS URIDYLYLATED TO P-II-UMP, FT THESE EVENTS ARE REVERSED." FT /note="Rv2919c, (MTCY338.08c), len: 112 aa. Probable glnB, FT nitrogen regulatory protein, highly similar to others e.g. FT Q9X705|GLNB PII PROTEIN from Corynebacterium glutamicum FT (Brevibacterium flavum) (112 aa), FASTA scores: opt: 531, FT E(): 4.5e-30, (68.75% identity in 112 aa overlap); FT P21193|GLNB_AZOBR NITROGEN REGULATORY PROTEIN P-II from FT Azospirillum brasilense (112 aa), FASTA scores: opt: 496, FT E(): 1.2e-27, (60.7% identity in 112 aa overlap); FT P05826|GLNB_ECOLI|B2553|Z3829|ECS3419|STY2808 NITROGEN FT REGULATORY PROTEIN P-II from Escherichia coli strains K12 FT and O157:H7 (112 aa), FASTA scores: opt: 487, E(): 5.3e-27, FT (61.6% identity in 112 aa overlap); etc. Contains PS00496 FT P-II protein urydylation site. BELONGS TO THE P(II) PROTEIN FT FAMILY." FT /db_xref="GOA:P64249" FT /db_xref="InterPro:IPR002332" FT /db_xref="PDB:3BZQ" FT /db_xref="UniProtKB/Swiss-Prot:P64249" FT /protein_id="CAA98972.1" FT /translation="MKLITAIVKPFTLDDVKTSLEDAGVLGMTVSEIQGYGRQKGHTEV FT YRGAEYSVDFVPKVRIEVVVDDSIVDKVVDSIVRAARTGKIGDGKVWVSPVDTIVRVRT FT GERGHDAL" FT misc_feature complement(111887..111904) FT /note="PS00496 P-II protein urydylation site" FT CDS complement(112036..113469) FT /transl_table=11 FT /gene="amt" FT /locus_tag="Rv2920c" FT /product="PROBABLE AMMONIUM-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN AMT" FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF AMMONIUM FT ACROSS THE MEMBRANE (EXPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2920c, (MTCY338.09c), len: 477 aa. Probable amt, FT ammonium-transport integral membrane protein (ala-, gly-, FT leu-, val-rich protein), highly similar to others e.g. FT Q9ZBP6|SC7A1.27 AMMONIUM TRANSPORTER from Streptomyces FT coelicolor (448 aa), FASTA scores: opt: 1246, E(): 7.3e-67, FT (54.1% identity in 462 aa overlap); P54146|AMT_CORGL FT AMMONIUM TRANSPORT SYSTEM from Corynebacterium glutamicum FT (452 aa), FASTA scores: opt: 953, E(): 2.1e-49, (41.45% FT identity in 475 aa overlap); Q07429|NRGA_BACSU PROBABLE FT AMMONIUM TRANSPORTER (MEMBRANE PROTEIN NRGA) from Bacillus FT subtilis (404 aa), FASTA scores: opt: 721, E(): 0, (44.4% FT identity in 430 aa overlap); etc. BELONGS TO THE FT AMT1/MEP/NRGA FAMILY OF AMMONIUM TRANSPORTERS (TC 2.49)." FT /db_xref="GOA:P63519" FT /db_xref="InterPro:IPR018047" FT /db_xref="UniProtKB/Swiss-Prot:P63519" FT /protein_id="CAA98980.1" FT /translation="MDQFPIMGVPDGGDTAWMLVSSALVLLMTPGLAFFYGGMVRSKSV FT LNMIMMSISAMGVVTVLWALYGYSIAFGDDVGNIAGNPSQYWGLKGLIGVNAVAADPST FT QTAAVNIPLAGTLPATVFVAFQLMFAIITVALISGAVADRLKFGAWLLFAGLWATFVYF FT PVAHWVFAFDGFAAEHGGWIANKLHAIDFAGGTAVHINAGVAALMLAIVLGKRRGWPAT FT LFRPHNLPFVMLGAALLWFGWYGFNAGSATTANGVAGATFVTTTIATAAAMLGWLLTER FT VRDGKATTLGAASGIVAGLVAITPSCSSVNVLGALAVGVSAGVLCALAVGLKFKLGFDD FT SLDVVGVHLVGGLVGTLLVGLLAAPEAPAINGVAGVSKGLFYGGGFAQLERQALGACSV FT LVYSGIITLILALILKFTIGLRLDAEQESTGIDEAEHAESGYDFAVASGSVLPPRVTVE FT DSRNGIQERIGQKVEAEPK" FT CDS complement(113834..115102) FT /transl_table=11 FT /gene="ftsY" FT /locus_tag="Rv2921c" FT /product="PROBABLE CELL DIVISION PROTEIN FTSY (SRP FT RECEPTOR) (SIGNAL RECOGNITION PARTICLE RECEPTOR)" FT /function="PROBABLY INVOLVED IN THE RECEPTION AND INSERTION FT OF A SUBSET OF PROTEINS AT THE MEMBRANE: POSSIBLY MEMBRANE FT RECEPTOR FOR FFH|Rv2916c." FT /note="Rv2921c, (MTCY338.10c, MT2989), len: 422 aa. FT Probable ftsY, signal recognition particle (SRP) receptor, FT a membrane-associated cell division protein (see citation FT below), equivalent to O33010|FTSY_MYCLE CELL DIVISION FT PROTEIN FTSY HOMOLOG from Mycobacterium leprae (430 aa), FT FASTA scores: opt: 1760, E(): 1.1e-108, (81.35% identity in FT 429 aa overlap). Also similar to others e.g. FT Q9I6C1|FTSY|PA0373 SIGNAL RECOGNITION PARTICLE RECEPTOR FT FTSY from Pseudomonas aeruginosa (455 aa), FASTA scores: FT opt: 882, E(): 5.1e-40, (42.08% identity in 385 aa FT overlap); Q9KVJ6|FTSY CELL DIVISION PROTEIN from Vibrio FT cholerae (391 aa), FASTA scores: opt: 837, E(): 1.2e-37, FT (36.3% identity in 394 aa overlap); FT P10121|FTSY_ECOLI|FTSY|B3464 CELL DIVISION PROTEIN from FT Escherichia coli strain K12 (497 aa), FASTA scores: opt: FT 800, E(): 1.3e-35, (39.75% identity in 327 aa overlap); FT etc. Also similar to Q9ZBP9|SC7A1.24 PUTATIVE PROKARYOTIC FT DOCKING PROTEIN from Streptomyces coelicolor (412 aa), FT FASTA scores: opt: 1461, E(): 4.3e-71, (60.3% identity in FT 423 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop), and PS00300 SRP54-type proteins FT GTP-binding domain signature. BELONGS TO THE SRP FAMILY OF FT GTP-BINDING PROTEINS." FT /db_xref="GOA:P66842" FT /db_xref="HSSP:1FTS" FT /db_xref="InterPro:IPR013822" FT /db_xref="UniProtKB/Swiss-Prot:P66842" FT /protein_id="CAA98981.1" FT /translation="MWEGLWIATAVIAALVVIAALTLGLVLYRRRRISLSPRPERGVVD FT RSGGYTASSGITFSQTPTTQPAERIDTSGLPAVGDDATVPRDAPKRTIADVHLPEFEPE FT PQAPEVPEADAIAPPEGRLERLRGRLARSQNALGRGLLGLIGGGDLDEDSWQDVEDTLL FT VADLGPAATASVVSQLRSRLASGNVRTEADARAVLRDVLINELQPGMDRSIRALPHAGH FT PSVLLVVGVNGTGKTTTVGKLARVLVADGRRVVLGAADTFRAAAADQLQTWAARVGAAV FT VRGPEGADPASVAFDAVDKGIAAGADVVLIDTAGRLHTKVGLMDELDKVKRVVTRRASV FT DEVLLVLDATIGQNGLAQARVFAEVVDISGAVLTKLDGTAKGGIVFRVQQELGVPVKLV FT GLGEGPDDLAPFEPAAFVDALLG" FT misc_feature complement(113879..113920) FT /note="PS00300 SRP54-type proteins GTP-binding domain FT signature" FT misc_feature complement(114392..114415) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(115152..118769) FT /transl_table=11 FT /gene="smc" FT /locus_tag="Rv2922c" FT /product="PROBABLE CHROMOSOME PARTITION PROTEIN SMC" FT /function="PLAYS AN IMPORTANT ROLE IN CHROMOSOME STRUCTURE FT AND PARTITIONING. ESSENTIAL FOR CHROMOSOME PARTITION." FT /note="Rv2922c, (MT2990, MTCY338.11c), len: 1205 aa. FT Probable smc, chromosome partition protein (ala-, arg-, FT leu-, glu-rich protein, possibly coiled-coil protein) (see FT * below), equivalent (but longer 84 aa) to FT Q9CBT5|SMC|ML1629|MLCB250.01 POSSIBLE CELL DIVISION PROTEIN FT from Mycobacterium leprae (1203 aa), FASTA scores: opt: FT 5957, E(): 0, (79.15% identity in 1205 aa overlap). Also FT highly similar to other chromosome segregation proteins FT e.g. Q9ZBQ2|SC7A1.21 PUTATIVE CHROMOSOME ASSOCIATED PROTEIN FT from Streptomyces coelicolor (1186 aa), FASTA scores: opt: FT 2633, E(): 4.1e-120, (53.03% identity in 1205 aa overlap); FT P51834|SMC_BACSU CHROMOSOME PARTITION PROTEIN from Bacillus FT subtilis (1186 aa), FASTA scores: opt: 1009, E(): 2.1e-41, FT (30.75% identity in 1205 aa overlap); Q9CHC9|SMC CHROMOSOME FT SEGREGATION PROTEIN from Lactococcus lactis (subsp. lactis) FT (Streptococcus lactis) (924 aa), FASTA scores: opt: 996, FT E(): 7.5e-41, (29.75% identity in 874 aa overlap); etc. FT Equivalent to AAK47317 from Mycobacterium tuberculosis FT strain CDC1551 (1205 aa) but longer 84 aa. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SMC FT FAMILY. N-terminus shortened since first submission. [* FT Note: Unpublished. Cobbe N., Heck M.M.S.- Phylogenetic FT analysis of SMC proteins (OCT-2001)]." FT /db_xref="GOA:Q10970" FT /db_xref="HSSP:1F2T" FT /db_xref="InterPro:IPR011890" FT /db_xref="UniProtKB/Swiss-Prot:Q10970" FT /protein_id="CAA98982.2" FT /translation="MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALA FT WVMGEQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVSIDNSDNALPIEYTEVSITRRM FT FRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLEEILQSRPEDRRAFIEE FT AAGVLKHRKRKEKALRKLDTMAANLARLTDLTTELRRQLKPLGRQAEAAQRAAAIQADL FT RDARLRLAADDLVSRRAEREAVFQAEAAMRREHDEAAARLAVASEELAAHESAVAELST FT RAESIQHTWFGLSALAERVDATVRIASERAHHLDIEPVAVSDTDPRKPEELEAEAQQVA FT VAEQQLLAELDAARARLDAARAELADRERRAAEADRAHLAAVREEADRREGLARLAGQV FT ETMRARVESIDESVARLSERIEDAAMRAQQTRAEFETVQGRIGELDQGEVGLDEHHERT FT VAALRLADERVAELQSAERAAERQVASLRARIDALAVGLQRKDGAAWLAHNRSGAGLFG FT SIAQLVKVRSGYEAALAAALGPAADALAVDGLTAAGSAVSALKQADGGRAVLVLSDWPA FT PQAPQSASGEMLPSGAQWALDLVESPPQLVGAMIAMLSGVAVVNDLTEAMGLVEIRPEL FT RAVTVDGDLVGAGWVSGGSDRKLSTLEVTSEIDKARSELAAAEALAAQLNAALAGALTE FT QSARQDAAEQALAALNESDTAISAMYEQLGRLGQEARAAEEEWNRLLQQRTEQEAVRTQ FT TLDDVIQLETQLRKAQETQRVQVAQPIDRQAISAAADRARGVEVEARLAVRTAEERANA FT VRGRADSLRRAAAAEREARVRAQQARAARLHAAAVAAAVADCGRLLAGRLHRAVDGASQ FT LRDASAAQRQQRLAAMAAVRDEVNTLSARVGELTDSLHRDELANAQAALRIEQLEQMVL FT EQFGMAPADLITEYGPHVALPPTELEMAEFEQARERGEQVIAPAPMPFDRVTQERRAKR FT AERALAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVADVDARILQVFN FT DAFVDVEREFRGVFTALFPGGEGRLRLTEPDDMLTTGIEVEARPPGKKITRLSLLSGGE FT KALTAVAMLVAIFRARPSPFYIMDEVEAALDDVNLRRLLSLFEQLREQSQIIIITHQKP FT TMEVADALYGVTMQNDGITAVISQRMRGQQVDQLVTNSS" FT misc_feature complement(118656..118679) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(118781..119062) FT /transl_table=11 FT /gene="acyP" FT /locus_tag="Rv2922A" FT /product="PROBABLE ACYLPHOSPHATASE ACYP (ACYLPHOSPHATE FT PHOSPHOHYDROLASE)" FT /function="INVOLVED IN CELLULAR METABOLISM [CATALYTIC FT ACTIVITY: AN ACYLPHOSPHATE + H(2)O = A FATTY ACID ANION + FT ORTHOPHOSPHATE]." FT /EC_number="3.6.1.7" FT /note="Rv2922A, len: 93 aa. Probable acyP, acylphosphatase FT (acylphosphate phosphohydrolase) (EC 3.6.1.7), highly FT similar to others e.g. Q9ZBQ3|SC7A1.20 PUTATIVE FT ACYLPHOSPHATASE from Streptomyces coelicolor (93 aa), FASTA FT scores: opt: 345, E(): 9.5e-19, (58.9% identity in 90 aa FT overlap); P75877|ACYP_ECOLI|YCCX|B0968|Z1320|ECS1052 FT PUTATIVE ACYLPHOSPHATASE from Escherichia coli strains K12 FT and O157:H7 (92 aa), FASTA scores: opt: 220, E(): 2e-09, FT (44.95% identity in 89 aa overlap); Q9RVU3|DR0929 PUTATIVE FT ACYLPHOSPHATASE from Deinococcus radiodurans (87 aa), FASTA FT scores: opt: 193, E(): 2.1e-07, (44.3% identity in 79 aa FT overlap); etc. BELONGS TO THE ACYLPHOSPHATASE FAMILY." FT /db_xref="GOA:P69419" FT /db_xref="InterPro:IPR017968" FT /db_xref="UniProtKB/Swiss-Prot:P69419" FT /protein_id="CAE55531.1" FT /translation="MSAPDVRLTAWVHGWVQGVGFRWWTRCRALELGLTGYAANHADGR FT VLVVAQGPRAACQKLLQLLQGDTTPGRVAKVVADWSQSTEQITGFSER" FT CDS complement(119049..119462) FT /transl_table=11 FT /locus_tag="Rv2923c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2923c, (MTCY338.12c), len: 137 aa. Conserved FT hypothetical protein, showing similarity with other FT hypothetical proteins e.g. FT P24246|YHFA_ECOLI|B3356|Z4717|ECS4207 from Escherichia coli FT strains K12 and O157:H7 (134 aa), FASTA scores: opt: 110, FT E(): 1.9, (25.9% identity in 135 aa overlap); etc." FT /db_xref="GOA:P65055" FT /db_xref="InterPro:IPR003718" FT /db_xref="UniProtKB/Swiss-Prot:P65055" FT /protein_id="CAA98973.1" FT /translation="MTQLWVERTGTRRYIGRSTRGAQVLVGSEDVDGVFTPGELLKIAL FT AACSGMASDQPLARRLGDDYQAVVKVSGAADRDQERYPLIEETMELDLSGLTEDEKERL FT LVVINRAVELACTVGRTLKSGTTVNLEVVDVGA" FT CDS complement(119564..120433) FT /transl_table=11 FT /gene="fpg" FT /locus_tag="Rv2924c" FT /standard_name="mutM" FT /product="PROBABLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE FPG FT (FAPY-DNA GLYCOSYLASE)" FT /function="INVOLVED IN BASE EXCISION REPAIR (REPAIR OF FT OXIDIZED PURINES). THIS ENZYME MAY PLAY A SIGNIFICANT ROLE FT IN PROCESSES LEADING TO RECOVERY FROM MUTAGENESIS AND/OR FT CELL DEATH BY ALKYLATING AGENTS [CATALYTIC ACTIVITY FT HYDROLYSIS OF DNA CONTAINING RING-OPENED N7-METHYLGUANINE FT RESIDUES, RELEASING FT 2,6-DIAMINO-4-HYDROXY-5-(N-METHYL)FORMAMIDOPYRIMIDE]." FT /EC_number="3.2.2.23" FT /note="Rv2924c, (MTCY338.13c), len: 289 aa. Probable fpg FT (alternate gene name: mutM), formamidopyrimidine-DNA FT glycosylase (EC 3.2.2.23) (see citation below), equivalent FT to O69470|FPG_MYCLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE FT from Mycobacterium leprae (282 aa), FASTA scores: opt: FT 1563, E(): 1.3e-96, (80.6% identity in 289 aa overlap). FT Also highly similar to other formamidopyrimidine-DNA FT glycosylases e.g. Q9ZBQ6|FPG_STRCO from Streptomyces FT coelicolor (286 aa), FASTA scores: opt: 1047, E(): 2.9e-62, FT (57.55% identity in 292 aa overlap); P95744|FPG_SYNEN from FT Synechococcus elongatus naegeli (284 aa), FASTA scores: FT opt: 569, E(): 1.9e-30, (37.95% identity in 290 aa FT overlap); P05523|FPG_ECOLI|MUTM|FPG|B3635 from Escherichia FT coli strain K12 (269 aa), FASTA scores: opt: 424, E(): FT 8.2e-21, (33.9% identity in 289 aa overlap); etc. BELONGS FT TO THE FPG FAMILY. COFACTOR: BINDS 1 ZINC ION." FT /db_xref="GOA:P64150" FT /db_xref="HSSP:1K82" FT /db_xref="InterPro:IPR012319" FT /db_xref="UniProtKB/Swiss-Prot:P64150" FT /protein_id="CAA98987.1" FT /translation="MPELPEVEVVRRGLQAHVTGRTITEVRVHHPRAVRRHDAGPADLT FT ARLRGARINGTDRRGKYLWLTLNTAGVHRPTDTALVVHLGMSGQMLLGAVPCAAHVRIS FT ALLDDGTVLSFADQRTFGGWLLADLVTVDGSVVPVPVAHLARDPLDPRFDCDAVVKVLR FT RKHSELKRQLLDQRVVSGIGNIYADEALWRAKVNGAHVAATLRCRRLGAVLHAAADVMR FT EALAKGGTSFDSLYVNVNGESGYFERSLDAYGREGENCRRCGAVIRRERFMNRSSFYCP FT RCQPRPRK" FT CDS complement(120792..121514) FT /transl_table=11 FT /gene="rnc" FT /locus_tag="Rv2925c" FT /product="PROBABLE RIBONUCLEASE III RNC (RNASE III)" FT /function="DIGESTS DOUBLE-STRANDED RNA. INVOLVED IN THE FT PROCESSING OF RIBOSOMAL RNA PRECURSORS AND OF SOME mRNAs FT [CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE TO FT 5'-PHOSPHOMONOESTER]." FT /EC_number="3.1.26.3" FT /note="Rv2925c, (MTCY338.14c), len: 240 aa. Probable rnc, FT ribonuclease III (RNase III) (EC 3.1.26.3), equivalent to FT O69469|RNC_MYCLE RIBONUCLEASE III from Mycobacterium leprae FT (238 aa). Also highly similar to other ribonucleases III FT e.g. Q9ZBQ7|RNC_STRCO from Streptomyces coelicolor (272 FT aa), FASTA scores: opt: 889, E(): 5.4e-51, (62.2% identity FT in 225 aa overlap) (N-terminus longer 21 aa); FT P51833|RNC_BACSU from Bacillus subtilis (249 aa), FASTA FT scores: opt: 493, E(): 5e-25, (43.25% identity in 215 aa FT overlap); P05797|RNC_ECOLI|RNC|B2567|Z3848|ECS3433 from FT Escherichia coli strain O157:H7 and K12 (226 aa), FASTA FT scores: opt: 459, E(): 7.9e-23, (41.8% identity in 213 aa FT overlap); etc. Contains PS00517 Ribonuclease III family FT signature." FT /db_xref="GOA:P66666" FT /db_xref="InterPro:IPR011907" FT /db_xref="PDB:2A11" FT /db_xref="UniProtKB/Swiss-Prot:P66666" FT /protein_id="CAA98974.1" FT /translation="MIRSRQPLLDALGVDLPDELLSLALTHRSYAYENGGLPTNERLEF FT LGDAVLGLTITDALFHRHPDRSEGDLAKLRASVVNTQALADVARRLCAEGLGVHVLLGR FT GEANTGGADKSSILADGMESLLGAIYLQHGMEKAREVILRLFGPLLDAAPTLGAGLDWK FT TSLQELTAARGLGAPSYLVTSTGPDHDKEFTAVVVVMDSEYGSGVGRSKKEAEQKAAAA FT AWKALEVLDNAMPGKTSA" FT misc_feature complement(121368..121394) FT /note="PS00517 Ribonuclease III family signature" FT CDS complement(121511..122134) FT /transl_table=11 FT /locus_tag="Rv2926c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2926c, (MTCY338.15c), len: 207 aa. Conserved FT hypothetical protein, equivalent to FT O69468|ML1660|MLCB1243.14 HYPOTHETICAL 23.5 KDA PROTEIN FT from Mycobacterium leprae (217 aa), FASTA scores: opt: 866, FT E(): 1.4e-48, (67.2% identity in 192 aa overlap). Also FT similar in part to other hypothetical proteins e.g. Q9WXZ8 FT CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima FT (182 aa), FASTA scores: opt: 254, E(): 3.4e-09, (31.45% FT identity in 143 aa overlap); Q9ZBQ9|SC7A1.14 HYPOTHETICAL FT 23.5 KDA PROTEIN from Streptomyces coelicolor (217 aa), FT FASTA scores: opt: 244, E(): 1.7e-08, (45.5% identity in FT 189 aa overlap); O65982 HYPOTHETICAL 26.2 KDA PROTEIN from FT Clostridium thermosaccharolyticum (Thermoanaerobacterium FT thermosaccharolyticum) (228 aa), FASTA scores: opt: 220, FT E(): 6.1e-07, (32.45% identity in 148 aa overlap); etc. FT Equivalent to AAK47323 from Mycobacterium tuberculosis FT strain CDC1551 (195 aa) but longer 12 aa." FT /db_xref="InterPro:IPR003772" FT /db_xref="UniProtKB/Swiss-Prot:P65057" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98983.1" FT /translation="MDLGGVRRRISLMARQHGPTAQRHVASPMTVDIARLGRRPGAMFE FT LHDTVHSPARIGLELIAIDQGALLDLDLRVESVSEGVLVTGTVAAPTVGECARCLSPVR FT GRVQVALTELFAYPDSATDETTEEDEVGRVVDETIDLEQPIIDAVGLELPFSPVCRPDC FT PGLCPQCGVPLASEPGHRHEQIDPRWAKLVEMLGPESDTLRGER" FT CDS complement(122185..122922) FT /transl_table=11 FT /locus_tag="Rv2927c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2927c, (MTCY338.16c), len: 245 aa. Conserved FT hypothetical protein, equivalent to FT Q9CBS6|ML1661|MLCB1243.13 (alias O69467) HYPOTHETICAL FT PROTEIN from Mycobacterium leprae (247 aa), FASTA scores: FT opt: 1440, E(): 4.9e-76, (90.6% identity in 245 aa FT overlap). Also similar to many hypothetical proteins from FT other organisms e.g. Q9ZBR0|SC7A1.13 HYPOTHETICAL 41.0 KDA FT PROTEIN from Streptomyces coelicolor (379 aa), FASTA FT scores: opt: 266, E(): 3.4e-08, (29.9% identity in 234 aa FT overlap); etc. Also some similarity with FT P46815|AG84_MYCLE|ML0922 ANTIGEN 84 from Mycobacterium FT leprae (266 aa), FASTA scores: opt: 193, E(): 0.00043, FT (28.7% identity in 136 aa overlap) (see citation below); FT and P46816|AG84_MYCTU|WAG31|Rv2145c|MT2204|MTCY270.23 FT ANTIGEN 84 from Mycobacterium tuberculosis (260 aa), FASTA FT scores: opt: 178, E(): 0.0031, (34.35% identity in 131 aa FT overlap) (see citation below). Contains potential FT coiled-coil region." FT /db_xref="UniProtKB/Swiss-Prot:P65059" FT /protein_id="CAA98984.1" FT /translation="MYRVFEALDELSAIVEEARGVPMTAGCVVPRGDVLELIDDIKDAI FT PGELDDAQDVLDARDSMLQDAKTHADSMVSSATTEAESILNHARTEADRILSDAKAQAD FT RMVSEARQHSERMVADAREEAIRIATAAKREYEASVSRAQAECDRLIENGNISYEKAVQ FT EGIKEQQRLVSQNEVVAAANAESTRLVDTAHAEADRLRGECDIYVDNKLAEFEEFLNGT FT LRSVGRGRHQLRTAAGTHDYAVR" FT CDS 123161..123946 FT /transl_table=11 FT /gene="tesA" FT /locus_tag="Rv2928" FT /product="PROBABLE THIOESTERASE TESA" FT /function="UNKNOWN; PROBABLY INVOLVED IN LIPID METABOLISM." FT /EC_number="3.1.2.-" FT /note="Rv2928, (MTCY338.17), len: 261 aa. Probable tesA, FT thioesterase (EC 3.1.2.-), equivalent to FT Q9Z5K4|ML2359|MLCB12.04c PUTATIVE THIOESTERASE from FT Mycobacterium leprae (261 aa), FASTA scores: opt: 1326, FT E(): 3.7e-80, (73.2% identity in 261 aa overlap). Also FT similar to others e.g. Q9ZGI1 THIOESTERASE II PIKAV from FT Streptomyces venezuelae (281 aa), FASTA scores: opt: 535, FT E(): 6.6e-28, (38.05% identity in 234 aa overlap); FT Q9L4W2|NYSE thioesterase involved in synthesis of the FT polyene antifungal antibiotic nystatin from Streptomyces FT noursei (see Brautaset et al., 2000) (251 aa), FASTA FT scores: opt: 523, E(): 3.8e-27, (34.53% identity in 223 aa FT overlap); Q54145 THIOESTERASE from Streptomyces fradiae FT (253 aa), FASTA scores: opt: 495, E(): 2.7e-25, (37.85% FT identity in 230 aa overlap); etc." FT /db_xref="GOA:P63460" FT /db_xref="InterPro:IPR001031" FT /db_xref="UniProtKB/Swiss-Prot:P63460" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98975.1" FT /translation="MLARHGPRYGGSVNGHSDDSSGDAKQAAPTLYIFPHAGGTAKDYV FT AFSREFSADVKRIAVQYPGQHDRSGLPPLESIPTLADEIFAMMKPSARIDDPVAFFGHS FT MGGMLAFEVALRYQSAGHRVLAFFVSACSAPGHIRYKQLQDLSDREMLDLFTRMTGMNP FT DFFTDDEFFVGALPTLRAVRAIAGYSCPPETKLSCPIYAFIGDKDWIATQDDMDPWRDR FT TTEEFSIRVFPGDHFYLNDNLPELVSDIEDKTLQWHDRA" FT CDS 123933..124244 FT /transl_table=11 FT /locus_tag="Rv2929" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2929, (MTCY338.18), len: 103 aa. Hypothetical FT unknown protein; unlikely ORF but some weak similarity to FT C-terminal half of P18319|UREG_KLEAE urease accessory FT protein from klebsiella aerogenes (205 aa), FASTA scores: FT opt: 99, E(): 1.1, (38.6% identity in 57 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P65061" FT /protein_id="CAA98976.1" FT /translation="MIELSYAPDVAGRRSNWPKGSGVNTWTAIRWTFAEDSPYVGTGLE FT RMASDTHGGGGGRPVTPPPPGMHHLGCSRGVLLISSQRDAGHKTCDPAAGGTLTSVLT" FT CDS 124660..126411 FT /transl_table=11 FT /gene="fadD26" FT /locus_tag="Rv2930" FT /product="FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA FT SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="INVOLVED IN PHTHIOCEROL DIMYCOCEROSATE (DIM) FT BIOSYNTHESIS, POSSIBLY BY ACTIVATING SUBSTRATES FOR THE PPS FT POLYKETIDES SYNTHASE." FT /EC_number="6.2.1.-" FT /note="Rv2930, (MT2999, MTCY338.19), len: 583 aa. fadD26, FT fatty-acid-CoA synthetase (EC 6.2.1.-) (see Camacho et al., FT 1999; 2001), equivalent to Q9Z5K5|FADD26|ML2358|MLCB12.03c FT PROBABLE ACYL-CoA SYNTHASE from Mycobacterium leprae (583 FT aa), FASTA scores: opt: 3026, E(): 9.2e-180, (76.85% FT identity in 583 aa overlap). Also highly similar to many FT e.g. Q9CD84|ML0132 PUTATIVE ACYL-CoA SYNTHETASE from FT Mycobacterium leprae (680 aa), FASTA scores: opt: 2324, FT E(): 3.2e-136, (61.35% identity in 572 aa overlap); P71495 FT ACYL-CoA SYNTHASE from Mycobacterium bovis (582 aa), FASTA FT scores: opt: 2304, E(): 5e-135, (59.85% identity in 583 aa FT overlap); etc. Also highly similar to others from FT Mycobacterium tuberculosis e.g. FT Q50586|FD25_MYCTU|RV1521|MTCY19G5.07 PUTATIVE FT FATTY-ACID--CoA LIGASE (583 aa), FASTA scores: opt: 2188, FT E(): 7.6e-128, (57.55% identity in 584 aa overlap); etc. FT BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. FT N-terminus shortened since first submission. Note that FT Rv2930|fadD26 belongs to the transcriptional unit FT Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:Q10976" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/Swiss-Prot:Q10976" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98985.2" FT /translation="MPVTDRSVPSLLQERADQQPDSTAYTYIDYGSDPKGFADSLTWSQ FT VYSRACIIAEELKLCGLPGDRVAVLAPQGLEYVLAFLGALQAGFIAVPLSTPQYGIHDD FT RVSAVLQDSKPVAILTTSSVVGDVTKYAASHDGQPAPVVVEVDLLDLDSPRQMPAFSRQ FT HTGAAYLQYTSGSTRTPAGVIVSHTNVIANVTQSMYGYFGDPAKIPTGTVVSWLPLYHD FT MGLILGICAPLVARRRAMLMSPMSFLRRPARWMQLLATSGRCFSAAPNFAFELAVRRTS FT DQDMAGLDLRDVVGIVSGSERIHVATVRRFIERFAPYNLSPTAIRPSYGLAEATLYVAA FT PEAGAAPKTVRFDYEQLTAGQARPCGTDGSVGTELISYGSPDPSSVRIVNPETMVENPP FT GVVGEIWVHGDHVTMGYWQKPKQTAQVFDAKLVDPAPAAPEGPWLRTGDLGVISDGELF FT IMGRIKDLLIVDGRNHYPDDIEATIQEITGGRAAAIAVPDDITEQLVAIIEFKRRGSTA FT EEVMLKLRSVKREVTSAISKSHSLRVADLVLVSPGSIPITTSGKIRRSACVERYRSDGF FT KRLDVAV" FT CDS 126408..132038 FT /transl_table=11 FT /gene="ppsA" FT /locus_tag="Rv2931" FT /product="PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE FT SYNTHASE PPSA" FT /function="INVOLVED IN PHENOLPTHIOCEROL AND PHTHIOCEROL FT DIMYCOCEROSATE (DIM) BIOSYNTHESIS: EXTENSION OF C18 WITH FT MALONY CoA (PARTIAL REDUCTION)." FT /note="Rv2931, (MTCY338.20), len: 1876 aa. ppsA, type-I FT polyketide synthase (see citations below), highly similar FT to others from Mycobacterium leprae e.g. FT Q9Z5K6|ML2357|MLCB12.02c PUTATIVE POLYKETIDE SYNTHASE from FT Mycobacterium leprae (1871 aa), FASTA scores: opt: 7566, FT E(): 0, (76.1% identity in 1888 aa overlap); FT Q9S384|ML2356|MLCB12.01c PUTATIVE POLYKETIDE SYNTHASE from FT Mycobacterium leprae (1540 aa), FASTA scores: opt: 4026, FT E(): 9.8e-212, (45.7% identity in 1811 aa overlap); FT Q49932|PKSC|L518_F1_2 PUTATIVE POLYKETIDE SYNTHASE (1446 FT aa), FASTA scores: opt: 4026, E(): 9.4e-212, (70.6% FT identity in 885 aa overlap). Also similar to polyketide FT synthases from other bacteria e.g. C-terminus of FT Q9L8C7|EPOC POLYKETIDE SYNTHASE from Polyangium cellulosum FT (7257 aa), FASTA scores: opt: 2592, E(): 5.2e-133, (32.55% FT identity in 2245 aa overlap); P22367|MSAS_PENPA FT 6-methylsalicylic acid synthase from Penicillium patulum FT (Penicillium griseofulvum) (1774 aa), FASTA scores: opt: FT 2391, E(): 0, (34.2% identity in 1815 aa overlap); etc. And FT also highly similar to others from Mycobacterium FT tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 PHENOLPTHIOCEROL FT SYNTHESIS POLYKETIDE SYNTHASE (1538 aa), FASTA scores: opt: FT 4227, E(): 0, (46.8% identity in 1810 aa overlap) (gap in FT middle); etc. Contains PS00606 Beta-ketoacyl synthases FT active site, and PS00012 Phosphopantetheine attachment FT site. Note that Rv2931|ppsA belongs to the transcriptional FT unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:Q10977" FT /db_xref="HSSP:1DNY" FT /db_xref="InterPro:IPR006163" FT /db_xref="UniProtKB/Swiss-Prot:Q10977" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98988.1" FT /translation="MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRD FT AVVLSGELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGARNSLDEPI FT AVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQRWQPFEGGPPEVAAALARTTRWG FT SFLPDIDAFDAEFFEISPSEADKMDPQQRLLLEVAWEALEHAGIPPGTLRRSATGVFAG FT ACLSEYGAMASADLSQVDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIH FT LACQSLRTQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGA FT GVVVLKRLTDAQRDGDRVLAVICGSAVNQDGRSNGLMAPNPAAQMAVLRAAYTNAGMQP FT SEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLLIGSVKTNLGHTEAAAGIAGF FT IKTVLAVQHGQIPPNQHFETANPHIPFTDLRMKVVDTQTEWPATGHPRRAGVSSFGFGG FT TNAHVVIEQGQEVRPAPGQGLSPAVSTLVVAGKTMQRVSATAGMLADWMEGPGADVALA FT DVAHTLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVNPADGSPGPGTVFVY FT SGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVLANGEELVGIEQIQLG FT LIGMQLALTELWCSYGVRPDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRSRLMAPLS FT GQGGMALLELDAPTTEALIADFPQVTLGIYNSPRQTVIAGPTEQIDELIARVRAQNRFA FT SRVNIEVAPHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQPVFDAEHWATN FT MRNPVRFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSAQPGARYTSLGTLQR FT DTDDVVTFRTNLNKAHTIHPPHTPHPPEPHPPIPTTPWQHTRHWITTKYPAGSVGSAPR FT AGTLLGQHTTVATVSASPPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAA FT TELGYSALSEVRFEQPIFADRPRLIQVVADNRAISLASSPAAGTPSDRWTRHVTAQLSS FT SPSDSASSLNEHHRANGQPPERAHRDLIPDLAELLAMRGIDGLPFSWTVASWTQHSSNL FT TVAIDLPEALPEGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGPRSSVT FT LNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRAQPPASTGPVEAYCD FT ATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIGDDGAALCETLEGAGYQPAVMSDG FT VSQARYVVYVADSDPAGADETDVDFAVRICTEITGLVRTLAERDADKPAALWILTRGVH FT ESVAPSALRQSFLWGLAGVIAAEHPELWGGLVDLAINDDLGEFGPALAELLAKPSKSIL FT VRRDGVVLAPALAPVRGEPARKSLQCRPDAAYLITGGLGALGLLMADWLADRGAHRLVL FT TGRTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEAVAADVGCREDVQALLAARD FT RDGAAPIRGIIHAAGITNDQLVTSMTGDAVRQVMWPKIGGSQVLHDAFPPGSVDFFYLT FT ASAAGIFGIPGQGSYAAANSYLDALARARRQQGCHTMSLDWVAWRGLGLAADAQLVSEE FT LARMGSRDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADGSGANAYLLPARNWSVMA FT ATEVRSELEQGLRRIIAAELRVPEKELDTDRPFAELGLNSLMAMAIRREAEQFVGIELS FT ATMLFNHPTVKSLASYLAKRVAPHDVSQDNQISALSSSAGSVLDSLFDRIESAPPEAER FT SV" FT misc_feature 127197..127247 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 131778..131825 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS 132035..136651 FT /transl_table=11 FT /gene="ppsB" FT /locus_tag="Rv2932" FT /product="PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE FT SYNTHASE PPSB" FT /function="INVOLVED IN PHENOLPTHIOCEROL AND PHTHIOCEROL FT DIMYCOCEROSATE (DIM) BIOSYNTHESIS: EXTENSION WITH MALONY FT CoA (PARTIAL REDUCTION)." FT /note="Rv2932, (MTV011.01, MTCY338.21, MT3002), len 1538 FT aa. ppsB, type-I polyketide synthase (see citations below), FT highly similar to others from Mycobacterium leprae e.g. FT Q9S384|ML2356|MLCB12.01c PUTATIVE POLYKETIDE SYNTHASE (1540 FT aa), FASTA scores: opt: 7284, E(): 0, (76.3% identity in FT 1561 aa overlap); Q49932|PKSC|L518_F1_2 PUTATIVE POLYKETIDE FT SYNTHASE (1446 aa), FASTA scores: opt: 6811, E(): 0, (76.2% FT identity in 1462 aa overlap); etc. Also similar to FT polyketide synthases from other bacteria e.g. Q9KIZ6|EPOE FT EPOE PROTEIN from Polyangium cellulosum (3798 aa), FASTA FT scores: opt: 3052, E(): 3.3e-165, (38.35% identity in 1538 FT aa overlap); etc. And also highly similar to others from FT Mycobacterium tuberculosis e.g. Q10977|PPSA_MYCTU|RV2931 FT PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1876 aa), FT FASTA scores: opt: 4227, E(): 0, (46.9% identity in 1810 aa FT overlap); P96203|PPSD|Rv2934|MTCY19H9.02 PKSE PROTEIN (1827 FT aa), FASTA scores: opt: 3756, E(): 1.8e-205, (42.9% FT identity in 1808 aa overlap); etc. Overlaps and extends CDS FT from neighbouring cosmid MTCY338.21. Contains PS00606 FT Beta-ketoacyl synthases active site. Note that Rv2932|ppsB FT belongs to the transcriptional unit FT Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:Q10978" FT /db_xref="InterPro:IPR016038" FT /db_xref="UniProtKB/Swiss-Prot:Q10978" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA15929.1" FT /translation="MMRTAFSRISGMTAQQRTSLADEFDRVSRIAVAEPVAVVGIGCRF FT PGDVDGPESFWDFLVAGRNAISTVPADRWDAEAFYHPDPLTPGRMTTKWGGFVPDVAGF FT DAEFFGITPREAAAMDPQQRMLLEVAWEALEHAGIPPDSLGGTRTAVMMGVYFNEYQSM FT LAASPQNVDAYSGTGNAHSITVGRISYLLGLRGPAVAVDTACSSSLVAVHLACQSLRLR FT ETDLALAGGVSITLRPETQIAISAWGLLSPQGRCAAFDAAADGFVRGEGAGVVVLKRLT FT DAVRDGDQVLAVVRGSAVNQDGRSNGVTAPNTAAQCDVIADALRSGDVAPDSVNYVEAH FT GTGTVLGDPIEFEALAATYGHGGDACALGAVKTNIGHLEAAAGIAGFIKATLAVQRATI FT PPNLHFSQWNPAIDAASTRFFVPTQNSPWPTAEGPRRAAVSSFGLGGTNAHVIIEQGSE FT LAPVSEGGEDTGVSTLVVTGKTAQRMAATAQVLADWMEGPGAEVAVADVAHTVNHHRAR FT QATFGTVVARDRAQAIAGLRALAAGQHAPGVVSHQDGSPGPGTVFVYSGRGSQWAGMGR FT QLLADEPAFAAAVAELEPVFVEQAGFSLRDVIATGKELVGIEQIQLGLIGMQLTLTELW FT RSYGVQPDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRARLMAPLSGQGGMALLGLDA FT AATEALIADYPQVTVGIYNSPRQTVIAGPTEQIDELIARVRAQNRFASRVNIEVAPHNP FT AMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQPIFDAEHWATNMRNPVRFQQAIA FT SAGSGADGAYHTFIEISAHPLLTQAIADTLEDAHRPTKSAAKYLSIGTLQRDADDTVTF FT RTNLYTADIAHPPHTCHPPEPHPTIPTTPWQHTHHWIATTHPSTAAPEDPGSNKVVVNG FT QSTSESRALEDWCHQLAWPIRPAVSADPPSTAAWLVVADNELCHELARAADSRVDSLSP FT PALAAGSDPAALLDALRGVDNVLYAPPVPGELLDIESAYQVFHATRRLAAAMVASSATA FT ISPPKLFIMTRNAQPISEGDRANPGHAVLWGLGRSLALEHPEIWGGIIDLDDSMPAELA FT VRHVLTAAHGTDGEDQVVYRSGARHVPRLQRRTLPGKPVTLNADASQLVIGATGNIGPH FT LIRQLARMGAKTIVAMARKPGALDELTQCLAATGTDLIAVAADATDPAAMQTLFDRFGT FT ELPPLEGIYLAAFAGRPALLSEMTDDDVTTMFRPKLDALALLHRRSLKSPVRHFVLFSS FT VSGLLGSRWLAHYTATSAFLDSFAGARRTMGLPATVVDWGLWKSLADVQKDATQISAES FT GLQPMADEVAIGALPLVMNPDAAVATVVVAADWPLLAAAYRTRGALRIVDDLLPAPEDV FT GKGESEFRTSLRSCPAEKRRDMLFDHVGALAATVMGMPPTEPLDPSAGFFQLGMDSLMS FT VTLQRALSESLGEFLPASVVFDYPTVYSLTDYLATVLPELLEIGATAVATQQATDSYHE FT LTEAELLEQLSERLRGTQ" FT misc_feature 132620..132670 FT /note="PS00606 Beta-ketoacyl synthases active site" FT CDS 136648..143214 FT /transl_table=11 FT /gene="ppsC" FT /locus_tag="Rv2933" FT /product="PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE FT SYNTHASE PPSC" FT /function="INVOLVED IN PHENOLPTHIOCEROL AND PHTHIOCEROL FT DIMYCOCEROSATE (DIM) BIOSYNTHESIS: EXTENSION WITH MALONY FT CoA (COMPLETE REDUCTION)." FT /note="Rv2933, (MTCY19H9.01, MTV011.02), len: 2188 aa. FT ppsC, type-I polyketide synthase (see citations below), FT highly similar to others from Mycobacterium leprae e.g. FT Q49933|PKSD|ML2355|L518_F1_3 PUTATIVE POLYKETIDE SYNTHASE FT (2201 aa), FASTA scores: opt: 6973, E(): 0, (82.32% FT identity in 2217 aa overlap); FT Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC FT ACID SYNTHASE (2118 aa), FASTA scores: opt: 4015, E(): FT 2.9e-208, (36.6% identity in 2184 aa overlap); etc. Also FT similar to polyketide synthases from other bacteria e.g. FT C-terminus of Q9L8C7 POLYKETIDE SYNTHASE from Polyangium FT cellulosum (7257 aa), FASTA scores: opt: 3909, E(): FT 3.6e-202, (40.15% identity in 2220 aa overlap); Q9KIZ7|EPOD FT EPOD PROTEIN from Polyangium cellulosum (7257 aa), FASTA FT scores: opt: 3886, E(): 6.2e-201, (40.05% identity in 2220 FT aa overlap); etc. And also highly similar to others from FT Mycobacterium tuberculosis e.g. P96291|Rv2940c (2111 aa), FT FASTA scores: opt: 4204, E(): 0, (39.1% identity in 2176 aa FT overlap); Q10977|PPSA_MYCTU|RV2931 PHENOLPTHIOCEROL FT SYNTHESIS POLYKETIDE SYNTHASE (1876 aa), FASTA scores: opt: FT 3793, E(): 2.4e-196, (46.65% identity in 1612 aa overlap); FT etc. Contains PS00606 Beta-ketoacyl synthases active site, FT and PS00012 Phosphopantetheine attachment site. Note that FT Rv2933|ppsC belongs to the transcriptional unit FT Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:P96202" FT /db_xref="InterPro:IPR016040" FT /db_xref="PDB:1PQW" FT /db_xref="UniProtKB/TrEMBL:P96202" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06099.1" FT /translation="MTAATPDRRAIITEALHKIDDLTARLEIAEKSSSEPIAVIGMGCR FT FPGGVNNPEQFWDLLCAGRSGIVRVPAQRWDADAYYCDDHTVPGTICSTEGGFLTSWQP FT DEFDAEFFSISPREAAAMDPQQRLLIEVAWEALEDAGVPQHTIRGTQTSVFVGVTAYDY FT MLTLAGRLRPVDLDAYIPTGNSANFAAGRLAYILGARGPAVVIDTACSSSLVAVHLACQ FT SLRGRESDMALVGGTNLLLSPGPSIACSRWGMLSPEGRCKTFDASADGYVRGEGAAVVV FT LKRLDDAVRDGNRILAVVRGSAVNQDGASSGVTVPNGPAQQALLAKALTSSKLTAADID FT YVEAHGTGTPLGDPIELDSLSKVFSDRAGSDQLVIGSVKTNLGHLEAAAGVAGLMKAVL FT AVHNGYIPRHLNFHQLTPHASEAASRLRIAADGIDWPTTGRPRRAGVSSFGVSGTNAHV FT VIEQAPDPMAAAGTEPQRGPVPAVSTLVVFGKTAPRVAATASVLADWLDGPGAAVPLAD FT VAHTLNHHRARQTRFGTVAAVDRRQAVIGLRALAAGQSAPGVVAPREGSIGGGTVFVYS FT GRGSQWAGMGRQLLADEPAFAAAIAELEPEFVAQGGFSLRDVIAGGKELVGIEQIQLGL FT IGMQLALTALWRSYGVTPDAVIGHSMGEVAAAVVAGALTPAQGLRVTAVRSRLMAPLSG FT QGTMALLELDAEATEALIADYPEVSLGIYASPRQTVISGPPLLIDELIDKVRQQNGFAT FT RVNIEVAPHNPAMDALQPAMRSELADLTPQPPTIPIISTTYADLGISLGSGPRFDAEHW FT ATNMRNPVRFHQAIAHAGADHHTFIEISAHPLLTHSISDTLRASYDVDNYLSIGTLQRD FT AHDTLEFHTNLNTTHTTHPPQTPHPPEPHPVLPTTPWQHTQHWITATSAAYHRPDTHPL FT LGVGVTDPTNGTRVWESELDPDLLWLADHVIDDLVVLPGAAYAEIALAAATDTFAVEQD FT QPWMISELDLRQMLHVTPGTVLVTTLTGDEQRCQVEIRTRSGSSGWTTHATATVARAEP FT LAPLDHEGQRREVTTADLEDQLDPDDLYQRLRGAGQQHGPAFQGIVGLAVTQAGVARAQ FT VRLPASARTGSREFMLHPVMMDIALQTLGATRTATDLAGGQDARQGPSSNSALVVPVRF FT AGVHVYGDITRGVRAVGSLAAAGDRLVGEVVLTDANGQPLLVVDEVEMAVLGSGSGATE FT LTNRLFMLEWEPAPLEKTAEATGALLLIGDPAAGDPLLPALQSSLRDRITDLELASAAD FT EATLRAAISRTSWDGIVVVCPPRANDESMPDEAQLELARTRTLLVASVVETVTRMGARK FT SPRLWIVTRGAAQFDAGESVTLAQTGLRGIARVLTFEHSELNTTLVDIEPDGTGSLAAL FT AEELLAGSEADEVALRDGQRYVNRLVPAPTTTSGDLAAEARHQVVNLDSSGASRAAVRL FT QIDQPGRLDALNVHEVKRGRPQGDQVEVRVVAAGLNFSDVLKAMGVYPGLDGAAPVIGG FT ECVGYVTAIGDEVDGVEVGQRVIAFGPGTFGTHLGTIADLVVPIPDTLADNEAATFGVA FT YLTAWHSLCEVGRLSPGERVLIHSATGGVGMAAVSIAKMIGARIYTTAGSDAKREMLSR FT LGVEYVGDSRSVDFADEILELTDGYGVDVVLNSLAGEAIQRGVQILAPGGRFIELGKKD FT VYADASLGLAALAKSASFSVVDLDLNLKLQPARYRQLLQHILQHVADGKLEVLPVTAFS FT LHDAADAFRLMASGKHTGKIVISIPQHGSIEAIAAPPPLPLVSRDGGYLIVGGMGGLGF FT VVARWLAEQGAGLIVLNGRSAPSDEVAAAIAELNASGSRIEVITGDITEPDTAERLVRA FT VEDAGFRLAGVVHSAMVLADEIVLNMTDSAARRVFAPKVTGSWRLHVATAARDVDWWLT FT FSSAAALLGTPGQGAYAAANSWVDGLVAHRRSAGLPAVGINWGPWADVGRAQFFKDLGV FT EMINAEQGLAAMQAVLTADRGRTGVFSLDARQWFQSFPAVAGSSLFAKLHDSAARKSGQ FT RRGGGAIRAQLDALDAAERPGHLASAIADEIRAVLRSGDPIDHHRPLETLGLDSLMGLE FT LRNRLEASLGITLPVALVWAYPTISDLATALCERMDYATPAAAQEISDTEPELSDEEMD FT LLADLVDASELEAATRGES" FT misc_feature 137248..137298 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 142945..142992 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS 143211..148694 FT /transl_table=11 FT /gene="ppsD" FT /locus_tag="Rv2934" FT /product="PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE FT SYNTHASE PPSD" FT /function="INVOLVED IN PHENOLPTHIOCEROL AND PHTHIOCEROL FT DIMYCOCEROSATE (DIM) BIOSYNTHESIS: EXTENSION WITH FT METHYLMALONY CoA (PARTIAL REDUCTION)." FT /note="Rv2934, (MTCY19H9.02), len: 1827 aa. ppsD, type-I FT polyketide synthase (see citations below), highly similar FT to others from Mycobacterium leprae e.g. Q9CB70|ML2354 FT POLYKETIDE SYNTHASE (1822 aa), FASTA scores: opt: 9779, FT E(): 0, (80.35% identity in 1836 aa overlap); FT Q49940|L518_F3_67|PFSE (1815 aa), FASTA scores: opt: 9658, FT E(): 0, (79.85% identity in 1831 aa overlap); etc. Also FT similar to polyketide synthases from other bacteria e.g. FT C-terminus of Q9RNB2|MCYD|Q9FDU1 POLYKETIDE SYNTHASE (MCYD FT PROTEIN) from Microcystis aeruginosa (3906 aa), FASTA FT scores: opt: 2961, E(): 6e-159, (32.15% identity in 1827 aa FT overlap); etc. And also highly similar to others from FT Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 FT PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1538 aa), FT FASTA scores: opt: 3756, E(): 3.8e-204, (42.85% identity in FT 1808 aa overlap) (gaps in middle); P96202|PPSC|RV2933 FT POLYKETIDE SYNTHASE (2188 aa), FASTA scores: opt: 3463, FT E(): 1.7e-187, (39.2% identity in 2165 aa overlap); etc. FT Contains PS00606 Beta-ketoacyl synthases active site, FT PS00017 ATP/GTP-binding site motif A, PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site, and PS00012 FT Phosphopantetheine attachment site. Note that Rv2934|ppsD FT belongs to the transcriptional unit FT Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:P96203" FT /db_xref="HSSP:1MLA" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P96203" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06093.1" FT /translation="MTSLAERAAQLSPNARAALARELVRAGTTFPTDICEPVAVVGIGC FT RFPGNVTGPESFWQLLADGVDTIEQVPPDRWDADAFYDPDPSASGRMTTKWGGFVSDVD FT AFDADFFGITPREAVAMDPQHRMLLEVAWEALEHAGIPPDSLSGTRTGVMMGLSSWDYT FT IVNIERRADIDAYLSTGTPHCAAVGRIAYLLGLRGPAVAVDTACSSSLVAIHLACQSLR FT LRETDVALAGGVQLTLSPFTAIALSKWSALSPTGRCNSFDANADGFVRGEGCGVVVLKR FT LADAVRDQDRVLAVVRGSATNSDGRSNGMTAPNALAQRDVITSALKLADVTPDSVNYVE FT THGTGTVLGDPIEFESLAATYGLGKGQGESPCALGSVKTNIGHLEAAAGVAGFIKAVLA FT VQRGHIPRNLHFTRWNPAIDASATRLFVPTESAPWPAAAGPRRAAVSSFGLSGTNAHVV FT VEQAPDTAVAAAGGMPYVSALNVSGKTAARVASAAAVLADWMSGPGAAAPLADVAHTLN FT RHRARHAKFATVIARDRAEAIAGLRALAAGQPRVGVVDCDQHAGGPGRVFVYSGQGSQW FT ASMGQQLLANEPAFAKAVAELDPIFVDQVGFSLQQTLIDGDEVVGIDRIQPVLVGMQLA FT LTELWRSYGVIPDAVIGHSMGEVSAAVVAGALTPEQGLRVITTRSRLMARLSGQGAMAL FT LELDADAAEALIAGYPQVTLAVHASPRQTVIAGPPEQVDTVIAAVATQNRLARRVEVDV FT ASHHPIIDPILPELRSALADLTPQPPSIPIISTTYESAQPVADADYWSANLRNPVRFHQ FT AVTAAGVDHNTFIEISPHPVLTHALTDTLDPDGSHTVMSTMNRELDQTLYFHAQLAAVG FT VAASEHTTGRLVDLPPTPWHHQRFWVTDRSAMSELAATHPLLGAHIEMPRNGDHVWQTD FT VGTEVCPWLADHKVFGQPIMPAAGFAEIALAAASEALGTAADAVAPNIVINQFEVEQML FT PLDGHTPLTTQLIRGGDSQIRVEIYSRTRGGEFCRHATAKVEQSPRECAHAHPEAQGPA FT TGTTVSPADFYALLRQTGQHHGPAFAALSRIVRLADGSAETEISIPDEAPRHPGYRLHP FT VVLDAALQSVGAAIPDGEIAGSAEASYLPVSFETIRVYRDIGRHVRCRAHLTNLDGGTG FT KMGRIVLINDAGHIAAEVDGIYLRRVERRAVPLPLEQKIFDAEWTESPIAAVPAPEPAA FT ETTRGSWLVLADATVDAPGKAQAKSMADDFVQQWRSPMRRVHTADIHDESAVLAAFAET FT AGDPEHPPVGVVVFVGGASSRLDDELAAARDTVWSITTVVRAVVGTWHGRSPRLWLVTG FT GGLSVADDEPGTPAAASLKGLVRVLAFEHPDMRTTLVDLDITQDPLTALSAELRNAGSG FT SRHDDVIAWRGERRFVERLSRATIDVSKGHPVVRQGASYVVTGGLGGLGLVVARWLVDR FT GAGRVVLGGRSDPTDEQCNVLAELQTRAEIVVVRGDVASPGVAEKLIETARQSGGQLRG FT VVHAAAVIEDSLVFSMSRDNLERVWAPKATGALRMHEATADCELDWWLGFSSAASLLGS FT PGQAAYACASAWLDALVGWRRASGLPAAVINWGPWSEVGVAQALVGSVLDTISVAEGIE FT ALDSLLAADRIRTGVARLRADRALVAFPEIRSISYFTQVVEELDSAGDLGDWGGPDALA FT DLDPGEARRAVTERMCARIAAVMGYTDQSTVEPAVPLDKPLTELGLDSLMAVRIRNGAR FT ADFGVEPPVALILQGASLHDLTADLMRQLGLNDPDPALNNADTIRDRARQRAAARHGAA FT MRRRPKPEVQGG" FT misc_feature 143802..143852 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 144642..144665 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 147939..147971 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT misc_feature 148428..148475 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS 148700..153166 FT /transl_table=11 FT /gene="ppsE" FT /locus_tag="Rv2935" FT /product="PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE FT SYNTHASE PPSE" FT /function="INVOLVED IN PHENOLPTHIOCEROL AND PHTHIOCEROL FT DIMYCOCEROSATE (DIM) BIOSYNTHESIS: EXTENSION WITH MALONY FT CoA (PARTIAL REDUCTION, DECARBOXYLATION)." FT /note="Rv2935, (MTCY19H9.03), len: 1488 aa. ppsE, type-I FT polyketide synthase (see citations below), equivalent to FT Q49934|PKSF|ML2353|L518_F1_8 PUTATIVE POLYKETIDE SYNTHASE FT from Mycobacterium leprae (1489 aa), FASTA scores: opt: FT 8156, E(): 0, (82.05% identity in 1493 aa overlap). Also FT similar to polyketide synthases from other bacteria e.g. FT Q9RAH3|NOSB NOSB PROTEIN from Nostoc sp. GSV224 (1244 aa), FT FASTA scores: opt: 2438, E(): 8.8e-137, (43.75% identity in FT 969 aa overlap); Q9KIZ8|EPOC EPOC PROTEIN from Polyangium FT cellulosum (1832 aa), FASTA scores: opt: 2272, E(): FT 8.6e-127, (39.95% identity in 1061 aa overlap); FT O54155|SC3F7.12 POLYKETIDE SYNTHASE from Streptomyces FT coelicolor (2297 aa), FASTA scores: opt: 1522, E(): FT 3.6e-82, (36.35% identity in 1057 aa overlap); etc. FT Contains PS00606 Beta-ketoacyl synthases active site. Note FT that Rv2935|ppsE belongs to the transcriptional unit FT Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:P96204" FT /db_xref="HSSP:1DNY" FT /db_xref="InterPro:IPR018201" FT /db_xref="UniProtKB/TrEMBL:P96204" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06094.1" FT /translation="MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQEL FT RDAGVSDKTLADPAYVRRAPLLDGIDEFDAGFFGFPPLAAQVLDPQHRLFLQCAWHALE FT DAGADPARFDGSIGVYGTSSPSGYLLHNLLSHRDPNAVLAEGLNFDQFSLFLQNDKDFL FT ATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYF FT TSPGSMVSAVGHCRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGSAINND FT GSAKMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQGLRAAFE FT VSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALPATLHYTSPNPELRLD FT QSPFVVQSKYGPWECDGVRRAGVSSFGVGGTNAHVVLEEAPAEASEVSAHAEPAGPQVI FT LLSAQTAAALGESRTALAAALETQDGPRLSDVAYTLARRRKHNVTMAAVVHDREHAATV FT LRAAEHDNVFVGEAAHDGEHGDRADAAPTSDRVVFLFPGQGAQHVGMAKGLYDTEPVFA FT QHFDTCAAGFRDETGIDLHAEVFDGTATDLERIDRSQPALFTVEYALAKLVDTFGVRAG FT AYIGYSTGEYIAATLAGVFDLQTAIKTVSLRARLMHESPPGAMVAVALGPDDVTQYLPP FT EVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSAMDPMLGQFQE FT FLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISSPIRFADELDVVLAAPSRIL FT VEVGPGGSLTGSAMRHPKWSTTHRTVRLMRHPLQDVDDRDTFLRALGELWSAGVEVDWT FT PRRPAVPHLVSLPGYPFARQRHWVEPNHTVWAQAPGANNGSPAGTADGSTAATVDAARN FT GESQTEVTLQRIWSQCLGVSSVDRNANFFDLGGDSLMAISIAMAAANEGLTITPQDLYE FT YPTLASLTAAVDASFASSGLAKPPEAQANPAVPPNVTYFLDRGLRDTGRCRVPLILRLD FT PKIGLPDIRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEFTGLSNRSVPNGVAAGS FT PEERAAVLGILAELLEDQTDPNAPLAAVHIAAAHGGPHYLCLAIHAMVTDDSSRQILAT FT DIVTAFGQRLAGEEITLEPVSTGWREWSLRCAALATHPAALDTRSYWIENSTKATLWLA FT DALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRRRFRRSIQTILLAALGRTIAQTV FT GEGVVAVELEGEGRSVLRPDVDLRRTVGWFTTYYPVPLACATGLGALAQLDAVHNTLKS FT VPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSGDAPVQFDSDMTLPVR FT EPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPAATAEALERTFPLALSALIQEAIAAE FT HTEHDDSEIVGEPEAGALVDLSSMDAG" FT misc_feature 149222..149272 FT /note="PS00606 Beta-ketoacyl synthases active site" FT CDS 153177..154172 FT /transl_table=11 FT /gene="drrA" FT /locus_tag="Rv2936" FT /product="PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING FT PROTEIN ABC TRANSPORTER DRRA" FT /function="PROBABLY INVOLVED IN ACTIVE TRANSPORT OF FT ANTIBIOTIC AND PHTHIOCEROL DIMYCOCEROSATE (DIM) ACROSS THE FT MEMBRANE (EXPORT). DRRA, DRRB|Rv2936|MTCY19H9.05 AND FT DRRC|Rv2938|MTCY19H9.06 MAY ACT JOINTLY TO CONFER FT DAUNORUBICIN AND DOXORUBICIN RESISTANCE BY AN EXPORT FT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT FT SYSTEM." FT /note="Rv2936, (MTCY19H9.04), len: 331 aa. Probable drrA, FT daunorubicin-DIM-transport resistance ATP-binding protein FT ABC transporter, probably involved in daunorubicin FT resistance and phthiocerol dimycocerosate transport (see FT citations below), equivalent to FT Q49938|DRRA|ML2352|L518_F2_43|DRRA PROBABLE DAUNORUBICIN FT RESISTANCE ATP-BINDING PROTEIN from Mycobacterium leprae FT (331 aa), FASTA scores: opt: 1842, E(): 4.2e-103, (85.2% FT identity in 331 aa overlap). Also highly similar to others FT e.g. Q9XCF7 DRRA from Mycobacterium avium (315 aa), FASTA FT scores: opt: 1040, E(): 4.7e-55, (54.35% identity in 309 aa FT overlap); Q9X5J8 DAUNORUBICIN RESISTANCE PROTEIN A from FT Mycobacterium avium (315 aa), FASTA scores: opt: 1030, E(): FT 1.9e-54, (53.7% identity in 309 aa overlap); FT P32010|DRRA_STRPE DAUNORUBICIN RESISTANCE ATP-BINDING FT PROTEIN from Streptomyces peucetius (330 aa), FASTA scores: FT opt: 852, E(): 9e-44, (47.15% identity in 318 aa overlap); FT etc. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00211 ABC transporters family signature. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS). Note that Rv2936|drrA belongs to the FT transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven FT experimentaly)." FT /db_xref="GOA:P96205" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:P96205" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06095.1" FT /translation="MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLLGPNG FT AGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQVAVDDALSGEQNLV FT LFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTYSGGMRRRIDIACGLVVQPQVAF FT LDEPTTGLDPRSRQAIWDLVASFKKLGIATLLTTQYLEEADALSDRIILIDHGIIIAEG FT TANELKHRAGDTFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIR FT MLVEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTESLTHLVSGSAR" FT misc_feature 153300..153323 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 153597..153641 FT /note="PS00211 ABC transporters family signature" FT CDS 154169..155038 FT /transl_table=11 FT /gene="drrB" FT /locus_tag="Rv2937" FT /product="PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL FT MEMBRANE PROTEIN ABC TRANSPORTER DRRB" FT /function="PROBABLY INVOLVED IN ACTIVE TRANSPORT OF FT ANTIBIOTIC AND PHTHIOCEROL DIMYCOCEROSATE (DIM) ACROSS THE FT MEMBRANE (EXPORT). DRRA|Rv2934|MTCY19H9.04, DRRB AND FT DRRC|Rv2938|MTCY19H9.06 MAY ACT JOINTLY TO CONFER FT DAUNORUBICIN AND DOXORUBICIN RESISTANCE BY AN EXPORT FT MECHANISM. PROBABLY RESPONSIBLE FOR THE TRANSLOCATION OF FT THE SUBSTRATE ACROSS THE MEMBRANE AND LOCALIZATION OF DIM FT INTO THE CELL WALL." FT /note="Rv2937, (MTCY19H9.05), len: 289 aa. Probable drrB, FT daunorubicin-DIM-transport integral membrane protein ABC FT transporter, probably involved in daunorubicin resistance FT and phthiocerol dimycocerosate transport (see citations FT below), equivalent to Q49935|DRRB|ML2351|L518_F1_9 FT DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from FT Mycobacterium leprae (288 aa), FASTA scores: opt: 1252, FT E(): 5.3e-72, (64.0% identity in 289 aa overlap). Also FT similar to others e.g. Q9XCF8 DRRB PROTEIN from FT Mycobacterium avium (246 aa), FASTA scores: opt: 423, E(): FT 1.5e-19, (30.85% identity in 243 aa overlap); Q9S6H4 FT DAUNORUBICIN RESISTANCE PROTEIN B from Mycobacterium avium FT (246 aa), FASTA scores: opt: 420, E(): 2.3e-19, (30.85% FT identity in 243 aa overlap); P32011|DRRB_STRPE DAUNORUBICIN FT RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces FT peucetius (283 aa), FASTA scores: opt: 242, E(): 4.7e-08, FT (27.85% identity in 219 aa overlap); etc. Note that FT Rv293|drrB belongs to the transcriptional unit FT Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:P96206" FT /db_xref="InterPro:IPR013525" FT /db_xref="UniProtKB/TrEMBL:P96206" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06096.1" FT /translation="MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLL FT NGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAVSFAAI FT GSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGFRFH FT RGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLK FT LFPHWIHPFVRNQPISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSS FT TIVLARRP" FT CDS 155035..155865 FT /transl_table=11 FT /gene="drrC" FT /locus_tag="Rv2938" FT /product="PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL FT MEMBRANE PROTEIN ABC TRANSPORTER DRRC" FT /function="PROBABLY INVOLVED IN ACTIVE TRANSPORT OF FT ANTIBIOTIC AND PHTHIOCEROL DIMYCOCEROSATE (DIM) ACROSS THE FT MEMBRANE (EXPORT). DRRA|Rv2934|MTCY19H9.04, FT DRRB|Rv2937|MTCY19H9.05 AND DRRC MAY ACT JOINTLY TO CONFER FT DAUNORUBICIN AND DOXORUBICIN RESISTANCE BY AN EXPORT FT MECHANISM. PROBABLY RESPONSIBLE FOR THE TRANSLOCATION OF FT THE SUBSTRATE ACROSS THE MEMBRANE AND LOCALIZATION OF DIM FT INTO THE CELL WALL." FT /note="Rv2938, (MTCY19H9.06), len: 276 aa. Probable drrC, FT daunorubicin-DIM-transport integral membrane protein ABC FT transporter, probably involved in daunorubicin resistance FT and phthiocerol dimycocerosate transport (see citations FT below), equivalent to Q9CB71|ML2350 PROBABLE ANTIBIOTIC FT RESISTANCE MEMBRANE PROTEIN from Mycobacterium leprae (276 FT aa), FASTA scores: opt: 1434, E(): 1.2e-81, (79.0% identity FT in 276 aa overlap); and Q49941|DRRC|L518_F3_76 PUTATIVE FT DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from FT Mycobacterium leprae (244 aa), FASTA scores: opt: 1194, FT E(): 8.3e-67, (76.85% identity in 242 aa overlap). Also FT similar to others e.g. Q9XCF9 DRRC PROTEIN from FT Mycobacterium avium (263 aa), FASTA scores: opt: 538, E(): FT 3.7e-26, (32.65% identity in 251 aa overlap); Q9S6H3 FT DAUNORUBICIN RESISTANCE PROTEIN C from Mycobacterium avium FT (263 aa), FASTA scores: opt: 533, E(): 7.6e-26, (32.25% FT identity in 251 aa overlap); P32011|DRRB_STRPE DAUNORUBICIN FT RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces FT peucetius (283 aa), FASTA scores: opt: 276, E(): 6.6e-10, FT (21.07% identity in 261 aa overlap); etc. Note that FT Rv2938|drrC belongs to the transcriptional unit FT Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:P96207" FT /db_xref="InterPro:IPR013525" FT /db_xref="UniProtKB/TrEMBL:P96207" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06097.1" FT /translation="MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDY FT ITVIGAIVLPILFMVVLNIVLGNLAYVVTHDSGLYSIVPLIALGAAITGSTFVAIDLMR FT ERSFGLLARLWVLPVHRASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLM FT WISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPF FT VAHQPVSYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH" FT CDS 155912..157180 FT /transl_table=11 FT /gene="papA5" FT /locus_tag="Rv2939" FT /product="POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED FT PROTEIN PAPA5" FT /function="THOUGHT TO BE INVOLVED IN PHTHIOCEROL FT DIMYCOCEROSATE (DIM) BIOSYNTHESIS." FT /note="Rv2939, (MTCY19H9.07), len: 422 aa. Possible papA5, FT conserved polyketide synthase (PKS) associated protein (see FT Camacho et al., 2001), equivalent to Q49939 HYPOTHETICAL FT 45.6 KDA PROTEIN from Mycobacterium leprae (423 aa), FASTA FT scores: opt: 2398, E(): 4.5e-144, (84.05% identity in 426 FT aa overlap); and Q02279|YMA3_MYCBO HYPOTHETICAL 38.1 KDA FT PROTEIN from Mycobacterium bovis (354 aa), FASTA scores: FT opt: 2193, E(): 3.6e-131, (97.4% identity in 343 aa FT overlap). And C-terminus highly similar to to Q9S381 FT HYPOTHETICAL 5.0 KDA PROTEIN (FRAGMENT) from Mycobacterium FT leprae (44 aa), FASTA scores: opt: 275, E(): 1.4e-10, FT (88.65% identity in 44 aa overlap). Also similar in part to FT various synthetases e.g. Q9AE01|RIF20 RIF20 PROTEIN from FT Amycolatopsis mediterranei (Nocardia mediterranei) (403 FT aa), FASTA scores: opt: 282, E(): 2.7e-10, (30.3% identity FT in 393 aa overlap); middle part of Q00869|ESYN1 ENNIATIN FT SYNTHETASE (FRAGMENT) (N-methyl peptide synthetase) from FT Fusarium equiseti (3131 aa), FASTA scores: opt: 180, E(): FT 0.0036, (26.85% identity in 242 aa overlap); N-terminus of FT Q9FB18 PEPTIDE SYNTHETASE NRPS2-1 from Streptomyces FT verticillus (2626 aa), FASTA scores: opt: 159, E(): 0.068, FT (23.65% identity in 351 aa overlap); etc. Note that FT Rv2939|papA5 belongs to the transcriptional unit FT Rv2930|fadD26-Rv2939|papA5 (proven experimentaly)." FT /db_xref="GOA:P96208" FT /db_xref="InterPro:IPR001242" FT /db_xref="PDB:1Q9J" FT /db_xref="UniProtKB/Swiss-Prot:P96208" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06098.1" FT /translation="MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDA FT LLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSL FT LHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLS FT MEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQ FT TSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEA FT TNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPP FT LVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEP FT GKSLEAIRSLLCTVPSEYGWIME" FT CDS complement(157343..163678) FT /transl_table=11 FT /gene="mas" FT /locus_tag="Rv2940c" FT /product="PROBABLE MULTIFUNCTIONAL MYCOCEROSIC ACID FT SYNTHASE MEMBRANE-ASSOCIATED MAS" FT /function="CATALYZES THE ELONGATION OF N-FATTY ACYL-COA FT WITH METHYLAMALONYL-CoA (NOT MALONYL-COA) AS THE ELONGATING FT AGENT TO FORM MYCOCEROSYL LIPIDS." FT /note="Rv2940c, (MTCY24G1.09, MTCY19H9.08c), len: 2111 aa. FT Probable mas, mycocerosic acid synthase membrane FT associated, multifunctional enzyme (see citations below), FT almost identical to Q02251|MCAS_MYCBO|MAS MYCOCEROSIC ACID FT SYNTHASE from Mycobacterium bovis (2110 aa), FASTA scores: FT opt: 13226, E(): 0, (95.8% identity in 2115 aa overlap) FT (see Mathur & Kolattukudy 1992); and equivalent to FT Q9CD78|MAS|ML0139 PUTATIVE MYCOCEROSIC SYNTHASE from FT Mycobacterium leprae (2116 aa), FASTA scores: opt: 12142, FT E(): 0, (87.95% identity in 2119 aa overlap); and FT Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC FT ACID SYNTHASE from Mycobacterium leprae (2118 aa), FASTA FT scores: opt: 8421, E(): 0, (60.8% identity in 2127 aa FT overlap). Also similar to other synthases e.g. C-terminus FT of Q9L8C7|EPOC POLYKETIDE SYNTHASE from Polyangium FT cellulosum (7257 aa), FASTA scores: opt: 4332, E(): 0, FT (40.85% identity in 2149 aa overlap); etc. Also similar to FT others from Mycobacterium tuberculosis e.g. FT O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 POLYKETIDE FT SYNTHASE (2108 aa), FASTA scores: opt: 5059, E(): 0, (65.9% FT identity in 2121 aa overlap); etc. Contains several FT domains, organized in the following order: beta-ketoacyl FT synthase (PS00606), acyl transferase, dehydratase-enoyl FT reductase, beta-ketoreductase, acyl carrier protein. FT Contains PS00012 Phosphopantetheine attachment site." FT /db_xref="GOA:P96291" FT /db_xref="HSSP:1PQW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P96291" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06108.1" FT /translation="MESRVTPVAVIGMGCRLPGGINSPDKLWESLLRGDDLVTEIPPDR FT WDADDYYDPEPGVPGRSVSRWGGFLDDVAGFDAEFFGISEREATSIDPQQRLLLETSWE FT AIEHAGLDPASLAGSSTAVFTGLTHEDYLVLTTTAGGLASPYVVTGLNNSVASGRIAHT FT LGLHGPAMTFDTACSSGLMAVHLACRSLHDGEADLALAGGCAVLLEPHASVAASAQGML FT SSTGRCHSFDADADGFVRSEGCAMVLLKRLPDALRDGNRIFAVVRGTATNQDGRTETLT FT MPSEDAQVAVYRAALAAAGVQPETVGVVEAHGTGTPIGDPIEYRSLARVYGAGTPCALG FT SAKSNMGHSTASAGTVGLIKAILSLRHGVVPPLLHFNRLPDELSDVETGLFVPQAVTPW FT PNGNDHTPKRVAVSSFGMSGTNVHAIVEEAPAEASAPESSPGDAEVGPRLFMLSSTSSD FT ALRQTARQLATWVEEHQDCVAASDLAYTLARGRAHRPVRTAVVAANLPELVEGLREVAD FT GDALYDAAVGHGDRGPVWVFSGQGSQWAAMGTQLLASEPVFAATIAKLEPVIAAESGFS FT VTEAITAQQTVTGIDKVQPAVFAVQVALAATMEQTYGVRPGAVVGHSMGESAAAVVAGA FT LSLEDAARVICRRSKLMTRIAGAGAMGSVELPAKQVNSELMARGIDDVVVSVVASPQST FT VIGGTSDTVRDLIARWEQRDVMAREVAVDVASHSPQVDPILDDLAAALADIAPMTPKVP FT YYSATLFDPREQPVCDGAYWVDNLRNTVQFAAAVQAAMEDGYRVFAELSPHPLLTHAVE FT QTGRSLDMSVAALAGMRREQPLPHGLRGLLTELHRAGAALDYSALYPAGRLVDAPLPAW FT THARLFIDDDGQEQRAQGACTITVHPLLGSHVRLTEEPERHVWQGDVGTSVLSWLSDHQ FT VHNVAALPGAAYCEMALAAAAEVFGEAAEVRDITFEQMLLLDEQTPIDAVASIDAPGVV FT NFTVETNRDGETTRHATAALRAAEDDCPPPGYDITALLQAHPHAVNGTAMRESFAERGV FT TLGAAFGGLTTAHTAEAGAATVLAEVALPASIRFQQGAYRIHPALLDACFQSVGAGVQA FT GTATGGLLLPLGVRSLRAYGPTRNARYCYTRLTKAFNDGTRGGEADLDVLDEHGTVLLA FT VRGLRMGTGTSERDERDRLVSERLLTLGWQQRALPEVGDGEAGSWLLIDTSNAVDTPDM FT LASTLTDALKSHGPQGTECASLSWSVQDTPPNDQAGLEKLGSQLRGRDGVVIVYGPRVG FT DPDEHSLLAGREQVRHLVRITRELAEFEGELPRLFVVTRQAQIVKPHDSGERANLEQAG FT LRGLLRVISSEHPMLRTTLIDVDEHTDVERVAQQLLSGSEEDETAWRNGDWYVARLTPS FT PLGHEERRTAVLDPDHDGMRVQVRRPGDLQTLEFVASDRVPPGPGQIEVAVSMSSINFA FT DVLIAFGRFPIIDDREPQLGMDFVGVVTAVGEGVTGHQVGDRVGGFSEGGCWRTFLTCD FT ANLAVTLPPGLTDEQAITAATAHATAWYGLNDLAQIKAGDKVLIHSATGGVGQAAISIA FT RAKGAEIFATAGNPAKRAMLRDMGVEHVYDSRSVEFAEQIRRDTDGYGVDIVLNSLTGA FT AQRAGLELLAFGGRFVEIGKADVYGNTRLGLFPFRRGLTFYYLDLALMSVTQPDRVREL FT LATVFKLTADGVLTAPQCTHYPLAEAADAIRAMSNAEHTGKLVLDVPRSGRRSVAVTPE FT QAPLYRRDGSYIITGGLGGLGLFFASKLAAAGCGRIVLTARSQPNPKARQTIEGLRAAG FT ADIVVECGNIAEPDTADRLVSAATATGLPLRGVLHSAAVVEDATLTNITDELIDRDWSP FT KVFGSWNLHRATLGQPLDWFCLFSSGAALLGSPGQGAYAAANSWVDVFAHWRRAQGLPV FT SAIAWGAWGEVGRATFLAEGGEIMITPEEGAYAFETLVRHDRAYSGYIPILGAPWLADL FT VRRSPWGEMFASTGQRSRGPSKFRMELLSLPQDEWAGRLRRLLVEQASVILRRTIDADR FT SFIEYGLDSLGMLEMRTHVETETGIRLTPKVIATNNTARALAQYLADTLAEEQAAAPAA FT S" FT misc_feature complement(157469..157516) FT /note="PS00012 Phosphopantetheine attachment site" FT misc_feature complement(163127..163177) FT /note="PS00606 Beta-ketoacyl synthases active site" FT CDS 164298..166040 FT /transl_table=11 FT /gene="fadD28" FT /locus_tag="Rv2941" FT /standard_name="acoas" FT /product="FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA FT SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="INVOLVED IN PHTHIOCEROL DIMYCOCEROSATE (DIM) FT BIOSYNTHESIS. THOUGHT TO BE INVOLVED IN THE RELEASE AND FT TRANSFER OF MYCOSEROSIC ACID FROM MAS ONTO THE DIOLS." FT /EC_number="6.2.1.-" FT /note="Rv2941, (MTCY24G1.08c), len: 580 aa. fadD28 FT (alternate gene name: acoas), fatty-acid-CoA synthetase (EC FT 6.2.1.-) (see citations below), almost identical to P71495 FT ACYL-CoA SYNTHASE from Mycobacterium bovis (582 aa), FASTA FT scores: opt: 3828, E(): 0, (99.15% identity in 580 aa FT overlap); and equivalent to Q9CD79|FADD28|ML0138 ACYL-CoA FT SYNTHETASE from Mycobacterium leprae (579 aa), FASTA FT scores: opt: 3183, E(): 8.8e-186, (81.9% identity in 580 aa FT overlap). And also highly similar to others Mycobacteria FT proteins e.g. O07797|FADD23|Rv3826|MTCY409.04c PUTATIVE FT FATTY-ACID-COA SYNTHETASE from Mycobacterium tuberculosis FT (584 aa); etc. Contains PS00018 EF-hand calcium-binding FT domain. Note that Rv2941|fadD28 and Rv2942|mmpL7 are FT transcriptionally coupled (proven experimentaly)." FT /db_xref="GOA:P96290" FT /db_xref="InterPro:IPR018247" FT /db_xref="PDB:3E53" FT /db_xref="UniProtKB/TrEMBL:P96290" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06100.1" FT /translation="MSVRSLPAALRACARLQPHDPAFTFMDYEQDWDGVAITLTWSQLY FT RRTLNVAQELSRCGSTGDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERS FT DSVLSDSSPVAILTTSSAVDDVVQHVARRPGESPPSIIEVDLLDLDAPNGYTFKEDEYP FT STAYLQYTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDGIPPPNSALVSWLPFYHD FT MGLVIGICAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELAARRTT FT DDDMAGRDLGNILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEATVYVAT FT SKPGQPPETVDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTCIECPDGT FT VGEIWVHGDNVANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSGFVTDGKMFII FT GRIKDLLIVYGRNHSPDDIEATIQEITRGRCAAISVPGDRSTEKLVAIIELKKRGDSDQ FT DAMARLGAIKREVTSALSSSHGLSVADLVLVAPGSIPITTSGKVRRGACVEQYRQDQFA FT RLDA" FT misc_feature 165786..165824 FT /note="PS00018 EF-hand calcium-binding domain" FT CDS 166033..168795 FT /transl_table=11 FT /gene="mmpL7" FT /locus_tag="Rv2942" FT /product="CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL7" FT /function="INVOLVED IN TRANSLOCATION OF PHTHIOCEROL FT DIMYCOCEROSATE (DIM) IN THE CELL WALL." FT /note="Rv2942, (MTCY24G1.07c), len: 920 aa. mmpL7, FT conserved transmembrane transport protein (see citations FT below), member of RND superfamily, highly similar to Q9XB10 FT HYPOTHETICAL 99.5 KDA PROTEIN from Mycobacterium bovis BCG FT (945 aa), FASTA scores: opt: 488, E(): 4.9e-20, (29.5% FT identity in 918 aa overlap); and to others from FT Mycobacteria e.g. O53735|MML4_MYCTU from Mycobacterium FT tuberculosis (945 aa), FASTA scores: opt: 481, E(): FT 1.2e-19, (25.9% identity in 922 aa overlap); etc. Also FT similar to other membrane proteins e.g. FT O54101|MMLB_STRCO|SC10A5.10c PUTATIVE MEMBRANE PROTEIN from FT Streptomyces coelicolor (847 aa), FASTA scores: opt: 256, FT E(): 7.2e-07, (25.15% identity in 545 aa overlap); etc. FT Contains PS00639 Eukaryotic thiol (cysteine) proteases FT histidine active site, PS00079 Multicopper oxidases FT signature 1, and PS00044 Bacterial regulatory proteins, FT lysR family signature. BELONGS TO THE MMPL FAMILY. Note FT that Rv2941|fadD28 and Rv2942|mmpL7 are transcriptionally FT coupled (proven experimentaly)." FT /db_xref="GOA:P65370" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/Swiss-Prot:P65370" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06107.1" FT /translation="MPSPAGRLHRIRYIRLKKSSPDCRATITSGSADGQRRSPRLTNLL FT VVAAWVAAAVIANLLLTFTQAEPHDTSPALLPQDAKTAAATSRIAQAFPGTGSNAIAYL FT VVEGGSTLEPQDQPYYDAAVGALRADTRHVGSVLDWWSDPVTAPLGTSPDGRSATAMVW FT LRGEAGTTQAAESLDAVRSVLRQLPPSEGLRASIVVPAITNDMPMQITAWQSATIVTVA FT AVIAVLLLLRARLSVRAAAIVLLTADLSLAVAWPLAAVVRGHDWGTDSVFSWTLAAVLT FT IGTITAATMLAARLGSDAGHSAAPTYRDSLPAFALPGACVAIFTGPLLLARTPALHGVG FT TAGLGVFVALAASLTVLPALIALAGASRQLPAPTTGAGWTGRLSLPVSSASALGTAAVL FT AICMLPIIGMRWGVAENPTRQGGAQVLPGNALPDVVVIKSARDLRDPAALIAINQVSHR FT LVEVPGVRKVESAAWPAGVPWTDASLSSAAGRLADQLGQQAGSFVPAVTAIKSMKSIIE FT QMSGAVDQLDSTVNVTLAGARQAQQYLDPMLAAARNLKNKTTELSEYLETIHTWIVGFT FT NCPDDVLCTAMRKVIEPYDIVVTGMNELSTGADRISAISTQTMSALSSAPRMVAQMRSA FT LAQVRSFVPKLETTIQDAMPQIAQASAMLKNLSADFADTGEGGFHLSRKDLADPSYRHV FT RESMFSSDGTATRLFLYSDGQLDLAAAARAQQLEIAAGKAMKYGSLVDSQVTVGGAAQI FT AAAVRDALIHDAVLLAVILLTVVALASMWRGAVHGAAVGVGVLASYLAALGVSIALWQH FT LLDRELNALVPLVSFAVLASCGVPYLVAGIKAGRIADEATGARSKGAVSGRGAVAPLAA FT LGGVFGAGLVLVSGGSFSVLSQIGTVVVLGLGVLITVQRAWLPTTPGRR" FT misc_feature 167035..167067 FT /note="PS00639 Eukaryotic thiol (cysteine) proteases FT histidine active site" FT misc_feature 168355..168432 FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT misc_feature 168688..168750 FT /note="PS00079 Multicopper oxidases signature 1" FT repeat_region 169426..171467 FT /mobile_element="insertion sequence:IS1533" FT /note="IS1533, len: 2042 bp. Minimum region corresponding FT to Insertion sequence IS1533." FT CDS 169427..170668 FT /transl_table=11 FT /locus_tag="Rv2943" FT /product="PROBABLE TRANSPOSASE FOR INSERTION SEQUENCE FT ELEMENT IS1533" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1533." FT /note="Rv2943, (MTCY24G1.06c), len: 413 aa. Probable FT transposase for insertion sequence IS1533, similar to other FT transposases e.g. P15025|ISTA_ECOLI ista protein (insertion FT sequence IS21) from Escherichia coli (390 aa), FASTA FT scores: opt: 268, E(): 5.1e-11, (24.1% identity in 378 aa FT overlap). Contains potential helix-turn-helix motif at aa FT 19-40 (Score 1611, +4.67 SD)." FT /db_xref="GOA:P96288" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/TrEMBL:P96288" FT /protein_id="CAB06106.1" FT /translation="MLTVEDWAEIRRLHRAEGLPIKMIARVLGISKNTVKSALESNQQP FT KYERAPQGSIVDAVEPRIRELLQAYPTMPATVIAERIGWERSIRVLSARVAELRPVYLP FT PDPASRTTYVAGEIAQCDFWFPPIELPVGFGQTRTAKQLPVLTMVCAYSRWLLAMLLPS FT RCAEDLFAGWWRLIEALGAVPRVLVWDGEGAIGRWRGGRSELTTECQAFRGTLAAKVLI FT CRPADPEAKGLIERAHDYLERSFLPGRVFASPADFNAQLGAWLALVNTRTRRALGCAPT FT DRIGADRAAMLSLPPVAPATGWCTSLRLPRDHYVRCDSNDYSVHPGVIGHRVLVRADLE FT RVHVFCDGELVADHERIWAVHQTVSDPAHVEAAKVLRRRHFSAASPVVEPQVQVRSLSD FT YDDALGVDIDGGVA" FT CDS 170668..171198 FT /transl_table=11 FT /locus_tag="Rv2943A" FT /product="POSSIBLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF AN INSERTION FT ELEMENT." FT /note="Rv2943A, len: 176 aa. Possible transposase, similar FT to many e.g. AJ238712|MBO238712_2 PUTATIVE TRANSPOSASE FT (IS21-l) from Mycobacterium bovis BCG (266 aa), FASTA FT scores: opt: 762, E(): 0, (100.0% identity in 118 aa FT overlap). Possible frameshift after codon 118 i.e. near FT position 3290056, to fuse with Rv2944." FT /db_xref="GOA:Q6MX22" FT /db_xref="InterPro:IPR002611" FT /db_xref="UniProtKB/TrEMBL:Q6MX22" FT /protein_id="CAE55532.1" FT /translation="MPTTKATQRRDVSTEIAYLTRALKAPTLRESVSRLADRARAENWS FT HEEYLAACLQREVSARESHGGEGRIRAARFPARKSLEEFDFEHARGLKRDTIAHLGTLD FT FITARDNVVFLGPAWHREDSSCGRPGDTRVSGRSSGAVRHRRRMGSTARRGSPRRAHLR FT RTHPALPLSAPGG" FT CDS 170753..171469 FT /transl_table=11 FT /locus_tag="Rv2944" FT /product="POSSIBLE TRANSPOSASE FOR INSERTION SEQUENCE FT ELEMENT IS1533" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1533" FT /note="Rv2944, (MTCY24G1.05c), len: 238 aa. Possible FT transposase for IS1533, similar to IS-element proteins e.g. FT P15026|ISTB_ECOLI istb protein from Escherichia coli (265 FT aa), FASTA scores: opt: 475, E (): 1.6e-21, (48.0% identity FT in 148 aa overlap); Z95436|MTY15C10_14 from Mycobacterium FT tuberculosis (248 aa), FASTA scores: opt: 784, E(): 0, FT (87.4% identity in 135 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:P96287" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:P96287" FT /protein_id="CAB06105.1" FT /translation="MSQCPGWPIAPAPRTGATKNTWPPACSGKCQPGSPMVVRAASAPP FT ASRLGSRWKSSTLSMLVASNATPSHIWAPWISSPPAITSCFWAPPGTGKTHLAVGLAIR FT ACQAGHRVLFATAAEWVARLAEAHHAGRIYAELTRLCRYPLLVVDEVGYIPFEPEAANL FT FFQLVSSRYERASLIVTSNKAFGRWGEVFGGDDVVAAAMIDRLVHHAEVVALKGDSYRL FT KDRDLGRVPPAGTTEE" FT misc_feature 171014..171037 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(171587..172288) FT /transl_table=11 FT /gene="lppX" FT /locus_tag="Rv2945c" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPPX" FT /function="UNKNOWN" FT /note="Rv2945c, (MTCY24G1.04), len: 233 aa. Probable lppX, FT conserved lipoprotein, equivalent to Q9CD80 PUTATIVE FT LIPOPROTEIN from Mycobacterium leprae (233 aa), FASTA FT scores: opt: 1165, E(): 2.1e-65, (76.4% identity in 233 aa FT overlap); and similar to Q9CCP6|ML0557 from Mycobacterium FT leprae (238 aa), FASTA scores: opt: 338, E(): 7.4e-14, FT (30.75% identity in 231 aa overlap). Also similar to others FT from Mycobacterium tuberculosis e.g. P71679|LPRG_MYCTU FT LIPOPROTEIN (236 aa), FASTA scores: opt: 342, E(): 4.1e-14, FT (32.05% identity in 231 aa overlap); etc. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site, and FT has in its N-terminal a signal peptide. BELONGS TO THE FT LPPX/LPRAFG FAMILY OF LIPOPROTEINS." FT /db_xref="GOA:P65306" FT /db_xref="InterPro:IPR009830" FT /db_xref="PDB:2BYO" FT /db_xref="UniProtKB/Swiss-Prot:P65306" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06104.1" FT /translation="MNDGKRAVTSAVLVVLGACLALWLSGCSSPKPDAEEQGVPVSPTA FT SDPALLAEIRQSLDATKGLTSVHVAVRTTGKVDSLLGITSADVDVRANPLAAKGVCTYN FT DEQGVPFRVQGDNISVKLFDDWSNLGSISELSTSRVLDPAAGVTQLLSGVTNLQAQGTE FT VIDGISTTKITGTIPASSVKMLDPGAKSARPATVWIAQDGSHHLVRASIDLGSGSIQLT FT QSKWNEPVNVD" FT misc_feature complement(172208..172240) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(172466..177316) FT /transl_table=11 FT /gene="pks1" FT /locus_tag="Rv2946c" FT /product="PROBABLE POLYKETIDE SYNTHASE PKS1" FT /function="POLYKETIDE SYNTHASE POSSIBLY INVOLVED IN LIPID FT SYNTHESIS" FT /note="Rv2946c, (MTCY24G1.03), len: 1616 aa. Probable pks1, FT polyketide synthase, similar to many e.g. FT ML035|AL583917|Q9CD81 putative polyketide synthase from FT Mycobacterium leprae (2103 aa), Fasta scores: opt: 8761, FT E(): 0, (82.6% identity in 1620 aa overlap); etc. Almost FT identical in part to G560507|Q50470 PKS002C protein from FT Mycobacterium tuberculosis (fragment) (950 aa), Fasta FT scores: opt: 5685, E(): 0, (95.3% identity in 927 aa FT overlap). Also similar to Mycobacterium tuberculosis FT polyketide synthases pks7|Rv1661|P94996 (2126 aa) (54.6% FT identity in 1632 aa); pks12|Rv2048c|O53490 (4151 aa) (58.0% FT identity in 1606 aa); pks8|rv1662|O65933 (1602 aa) (59.7% FT identity in 1144 aa). Contains a PS00012 Phosphopantetheine FT attachment site." FT /db_xref="GOA:P96285" FT /db_xref="HSSP:1PQW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P96285" FT /protein_id="CAB06103.1" FT /translation="MISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHR FT AVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGE FT LPVFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDW FT GVLPDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEV FT EPLLGEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPM FT LEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTL FT GATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQW FT SAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSD FT EVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVM FT HPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPP FT EGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMH FT PAVLDAVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDV FT CDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAP FT PAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAA FT TLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGE FT PQLLVRGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAG FT QVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLG FT GAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGG FT VGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGV FT DVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPA FT RMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRL FT ADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQ FT VVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDA FT AWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLA FT WGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAA FT LDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLV FT CLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPT FT AVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA" FT misc_feature complement(172640..172687) FT /note="PS00012 Phosphopantetheine attachment site" FT CDS complement(177313..178803) FT /transl_table=11 FT /gene="pks15" FT /locus_tag="Rv2947c" FT /product="PROBABLE POLYKETIDE SYNTHASE PKS15" FT /function="POLYKETIDE SYNTHASE POSSIBLY INVOLVED IN LIPID FT SYNTHESIS" FT /note="Rv2947c, (MTCY24G1.02), len: 496 aa. Probable pks15, FT polyketide synthase. Almost identical to G560508|Q50469 FT PKS002B protein from Mycobacterium tuberculosis (495 aa), FT FASTA scores: opt: 3270, E(): 0, (99.6% identity in 496 a a FT overlap). Similar to Mycobacterium tuberculosis proteins FT MTCY338.20|RV2931|PPSA_MYCTU ppsA phenolpthiocerol FT synthesis (1876 aa) (49.9% identity in 465 aa overlap); FT MTCY24G1.09|RV2940C|P96291 Putative mas, mycocerosic acid FT synthase (2111 aa) (50.2% identity in 454 aa overlap); and FT MTCY22H8.03|RV2382C|P71718 hypothetical protein (444 aa) FT (47.6% identity in 437 aa overlap). Contains PS00606 FT Beta-ketoacyl synthases active site." FT /db_xref="GOA:P96284" FT /db_xref="InterPro:IPR018201" FT /db_xref="UniProtKB/TrEMBL:P96284" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06102.1" FT /translation="MIEEQRTMSVEGADQQSEKLFHYLKKVAVELDETRARLREYEQRA FT TEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGKT FT YTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGIDPLSLRGSAT FT GVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYVLGLQGPAVSVDTACSSSLVA FT IHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGE FT GAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQVALANAGL FT SAADVDVVEAHGTATTLGDPIEAQALLSTYGQGGPAEQPLWVGSIKSNMGHTQAAAGVA FT GVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSVDGRPRRAAVSSFGI FT SGTNAHLILEEAPVPAPAEAPVEASESTGGRGRRWCRG" FT misc_feature complement(178135..178185) FT /note="PS00606 Beta-ketoacyl synthases active site" FT CDS complement(178800..180917) FT /transl_table=11 FT /gene="fadD22" FT /locus_tag="Rv2948c" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD22 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv2948c, (MTCY24G1.01), len: 705 aa. Probable FT fadD22, fatty-acid-CoA synthetase (EC 6.2.1.-). Highly FT similar to many e.g. Q9CD82|ML0134 putative acyl-CoA FT synthetase from Mycobacterium leprae (707 aa), fasta FT scores: opt: 3554, E(): 6.4e-209, (75.9% identity in 705 aa FT overlap). Almost identical to G560509|Q50468 PKS002A FT protein from Mycobacterium tuberculosis (705 aa), fasta FT scores: opt: 4647, E(): 0, (99.7% identity in 705 aa FT overlap)." FT /db_xref="GOA:P96283" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR009081" FT /db_xref="UniProtKB/TrEMBL:P96283" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06101.1" FT /translation="MRNGNLAGLLAEQASEAGWYDRPAFYAADVVTHGQIHDGAARLGE FT VLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPA FT LVVTSDALRDRFQPSRVAEAAELMSEAARVAPGGYEPMGGDALAYATYTSGTTGPPKAA FT IHRHADPLTFVDAMCRKALRLTPEDTGLCSARMYFAYGLGNSVWFPLATGGSAVINSAP FT VTPEAAAILSARFGPSVLYGVPNFFARVIDSCSPDSFRSLRCVVSAGEALELGLAERLM FT EFFGGIPILDGIGSTEVGQTFVSNRVDEWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEG FT DLWVRGPAIAKGYWNRPDSPVANEGWLDTRDRVCIDSDGWVTYRCRADDTEVIGGVNVD FT PREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGATIDGSVMRDLHRGLLNRL FT SAFKVPHRFAVVDRLPRTPNGKLVRGALRKQSPTKPIWELSLTEPGSGVRAQRDDLSAS FT NMTIAGGNDGGATLRERLVALRQERQRLVVDAVCAEAAKMLGEPDPWSVDQDLAFSELG FT FDSQMTVTLCKRLAAVTGLRLPETVGWDYGSISGLAQYLEAELAGGHGRLKSAGPVNSG FT ATGLWAIEEQLNKVEELVAVIADGEKQRVADRLRALLGTIAGSEAGLGKLIQAASTPDE FT IFQLIDSELGK" FT CDS complement(180934..181533) FT /transl_table=11 FT /locus_tag="Rv2949c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2949c, (MTCY349.41), len: 199 aa. Conserved FT hypothetical protein, equivalent to Q9CD83|ML0133 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (210 aa), FT FASTA scores: opt: 797, E(): 7.4e-47, (62.55% identity in FT 195 aa overlap). Equivalent to AAK47348 from Mycobacterium FT tuberculosis strain CDC1551 (212 aa) but shorter 13 aa." FT /db_xref="GOA:O86325" FT /db_xref="InterPro:IPR002800" FT /db_xref="UniProtKB/Swiss-Prot:O86325" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06109.1" FT /translation="MTECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIV FT KQRIHDVSPKLSEFEQLGQVGVGRVLQRYIILKGRNSEHLFVAAESLIAIDRLPAAIIT FT RLTQTNDPLGEVMAASHIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVISGG FT QPIMVVTEHFLRSVFRDAPHEEPDRWQFSNAITLAR" FT CDS complement(181559..183418) FT /transl_table=11 FT /gene="fadD29" FT /locus_tag="Rv2950c" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD29 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv2950c, (MTCY349.40), len: 619 aa. Probable fadD29, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to various FT mycobacterial enzymes believed to be involved in polyketide FT or fatty acid synthesis. Equivalent (but shorter 61 aa) to FT Q9CD84 from Mycobacterium leprae (680 aa), FASTA scores: FT opt: 3280, E(): 2.2e-192, (80.15% identity in 620 aa FT overlap); and highly similar to others from Mycobacterium FT leprae e.g. Q9Z5K5 PROBABLE ACYL-COA SYNTHASE (583 aa), FT FASTA scores: opt: 2358, E(): 3.4e-136, (62.35% identity in FT 579 aa overlap). Also similar to others from Mycobacterium FT tuberculosis e.g. Q10976|FD26_MYCTU PUTATIVE FT FATTY-ACID--CoA LIGASE (583 aa), FASTA scores: opt: 2416, FT E(): 1e-139, (63.15% identity in 581 aa overlap) FT (N-terminus shorter); etc. Equivalent to AAK47349 from FT Mycobacterium tuberculosis strain CDC1551 (582 aa) but FT longer 37 aa." FT /db_xref="GOA:P95141" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:P95141" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05426.1" FT /translation="MKTNSSFHAAGEVATQPAWGTGEQAAQPLNGSTSRFAMSESSLAD FT LLQKAASQYPNRAAYKFIDYDTDPAGFTETVTWWQVHRRAMIVAEELWIYASSGDRVAI FT LAPQGLEYIIAFMGVLQAGLIAVPLPVPQFGIHDERISSALRDSAPSIILTTSSVIDEV FT TTYAPHACAAQGQSAPIVVAVDALDLSSSRALDPTRFERPSTAYLQYTSGSTRAPAGVV FT LSHKNVITNCVQLMSDYIGDSEKVPSTPVSWLPFYHDMGLMLGIILPMINQDTAVLMSP FT MAFLQRPARWMQLLAKHRAQISSAPNFGFELAVRRTSDDDMAGLDLGHVRTIVTGAERV FT NVATLRRFTERFAPFNLSETAIRPSYGLAEATVYVATAGPGRAPKSVCFDYQQLSVGQA FT KRAENGSEGANLVSYGAPRASTVRIVDPETRMENPAGTVGEIWVQGDNVGLGYWRNPQQ FT TEATFRARLVTPSPGTSEGPWLRTGDLGVIFEGELFITGRIKELLVVDGANHYPEDIEA FT TIQEITGGRVVAIAVPDDRTEKLVTIIELMKRGRTDEEEKNRLRTVKREVASAISRSHR FT LRVADVVMVAPGSIPVTTSGKVRRSASVERYLHHEFSRLDAMA" FT CDS complement(184066..185211) FT /transl_table=11 FT /locus_tag="Rv2951c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv2951c, (MTCY349.39), len: 381 aa. Possible FT oxidoreductase (EC 1.-.-.-), equivalent to Q9CD85 PUTATIVE FT OXIDOREDUCTASE from Mycobacterium leprae (382 aa), FASTA FT scores: opt: 2225, E(): 7.6e-134, (84.8% identity in 382 aa FT overlap); and similar to O30260 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium leprae (363 aa), FASTA scores: FT opt: 652, E(): 6.1e-34, (32.55% identity in 344 aa FT overlap). Also similar to various oxidoreductases e.g. FT O29071|AF1196 N5,N10-METHYLENETETRAHYDROMETHANOPTERIN FT REDUCTASE from Archaeoglobus fulgidus (348 aa), FASTA FT scores: opt: 381, E(): 9.7e-17, (27.7% identity in 354 aa FT overlap); Q58929|MER|MJ1534 F420-DEPENDENT FT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) FT from Methanococcus jannaschii (331 aa), FASTA scores: opt: FT 372, E(): 3.5e-16, (30.85% identity in 295 aa overlap); FT Q9UXP0 PUTATIVE F420-DEPENDENT FT N5,N10-METHYLENE-TETRAHYDROMETHANOPTERIN REDUCTASE from FT Methanolobus tindarius (326 aa), FASTA scores: opt: 343, FT E(): 2.4e-14, (27.4% identity in 314 aa overlap); etc." FT /db_xref="GOA:P95140" FT /db_xref="InterPro:IPR016048" FT /db_xref="UniProtKB/Swiss-Prot:P95140" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05425.1" FT /translation="MGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLN FT ALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPA FT VTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGE FT LISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDY FT SRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAW FT ARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAE FT WRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL" FT CDS 185404..186216 FT /transl_table=11 FT /locus_tag="Rv2952" FT /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" FT /function="THOUGHT TO CAUSE METHYLATION." FT /EC_number="2.1.1.-" FT /note="Rv2952, (MTCY349.38), len: 270 aa. Probable FT methyltransferase (EC 2.1.1.-), equivalent to Q9CD86|ML0130 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (270 aa), FT FASTA scores: opt: 1584, E(): 6.1e-99, (83.7% identity in FT 270 aa overlap). Also highly similar to Q9RMN9|MTF2 FT PUTATIVE METHYLTRANSFERASE from Mycobacterium smegmatis FT (274 aa), FASTA scores: opt: 902, E(): 3.8e-53, (56.35% FT identity in 252 aa overlap). Also similar to other FT methyltransferases e.g. Q9ADL4|SORM O-METHYLTRANSFERASE FT from Polyangium cellulosum (346 aa), FASTA scores: opt: FT 390, E(): 1.1e-18, (36.25% identity in 251 aa overlap); FT Q54303|RAPM METHYLTRANSFERASE from Streptomyces FT hygroscopicus (317 aa), FASTA scores: opt: 315, E(): FT 1.1e-13, (40.75% identity in 135 aa overlap); etc. Very FT similar to C-terminal part of Q50584|Rv1523|MTCY19G5.05c FT HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium FT tuberculosis (358 aa), FASTA score: opt: 965, E(): 2.7e-57, FT (60.3% identity in 247 aa overlap)." FT /db_xref="GOA:Q50464" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:Q50464" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05424.1" FT /translation="MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDEIVFINWA FT YEEDPPMDLPLEASDEPNRAHINLYHRTATQVDLGGKQVLEVSCGHGGGASYLTRTLHP FT ASYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESFDVVLNVEASHCYPHFRR FT FLAEVVRVLRPGGYFPYADLRPNNEIAAWEADLAATPLRQLSQRQINAEVLRGIGNNSQ FT KSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYCFTKD" FT CDS 186242..187498 FT /transl_table=11 FT /locus_tag="Rv2953" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2953, (MTCY349.37c), len: 418 aa. Conserved FT hypothetical protein, equivalent to Q9CD87|ML0129 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (418 aa), FT FASTA scores: opt: 2357, E(): 2.7e-143, (86.6% identity in FT 418 aa overlap). Also highly similar to Q9X7N5|SC5F2A.12c FT CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor FT (396 aa), FASTA scores: opt: 491, E(): 7e-24, (38.35% FT identity in 417 aa overlap); and similar to other FT hypothetical proteins e.g. Q9VG81 CG5167 PROTEIN from FT Drosophila melanogaster (Fruit fly) (431 aa), FASTA scores: FT opt: 393, E(): 1.4e-17, (26.55% identity in 433 aa FT overlap); Q9GZE9|F22F7.1 HYPOTHETICAL PROTEIN from FT Caenorhabditis elegans (426 aa), FASTA scores: opt: 338, FT E(): 4.6e-14, (27.05% identity in 425 aa overlap); FT P73855|SLL1601 HYPOTHETICAL 44.8 KDA PROTEIN from FT Synechocystis sp. (strain PCC 6803) (414 aa), FASTA scores: FT opt: 565, E(): 1.3e-28, (35.7% identity in 409 aa overlap); FT etc. Also highly similar to other proteins from FT Mycobacterium tuberculosis e.g. RV2449C|O53176|MTV008.05C FT HYPOTHETICAL 44.4 KDA PROTEIN (419 aa), FASTA scores: opt: FT 1835, E(): 7e-110, (67.55% identity in 419 aa overlap); FT etc." FT /db_xref="GOA:P95139" FT /db_xref="InterPro:IPR005097" FT /db_xref="UniProtKB/Swiss-Prot:P95139" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05423.1" FT /translation="MSPAEREFDIVLYGATGFSGKLTAEHLAHSGSTARIALAGRSSER FT LRGVRMMLGPNAADWPLILADASQPLTLEAMAARAQVVLTTVGPYTRYGLPLVAACAKA FT GTDYADLTGELMFCRNSIDLYHKQAADTGARIILACGFDSIPSDLNVYQLYRRSVEDGT FT GELCDTDLVLRSFSQRWVSGGSVATYSEAMRTASSDPEARRLVTDPYTLTTDRGAEPEL FT GAQPDFLRRPGRDLAPELAGFWTGGFVQAPFNTRIVRRSNALQEWAYGRRFRYSETMSL FT GKSMAAPILAAAVTGTVAGTIGLGNKYFDRLPRRLVERVTPKPGTGPSRKTQERGHYTF FT ETYTTTTTGARYRATFAHNVDAYKSTAVLLAQSGLALALDRDRLAELRGVLTPAAAMGD FT ALLARLPGAGVVMGTTRLS" FT CDS complement(187629..188354) FT /transl_table=11 FT /locus_tag="Rv2954c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2954c, (MTCY349.36), len: 241 aa. Hypothetical FT unknown protein. Equivalent to AAK47354 from Mycobacterium FT tuberculosis strain CDC1551 (199 aa) but longer 42 aa." FT /db_xref="InterPro:IPR013217" FT /db_xref="UniProtKB/TrEMBL:Q50461" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05422.1" FT /translation="MRLPGMLRPTAERHFHSIFYLRHNARRQEHLATLGLDLGNKSVLE FT VGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSNPNVTVDHLDLDGDLPAEAHQ FT YDVVYCYGVLYHLSRPAEALAWMCDRAVDLLLLETCVSYSGEDEPFLVSERASSPSQAI FT TGTGCRPSRVWVMNRLREKMPHVYVTATQPRHRQFPLDWRANGPIASTGLARAVFVASR FT APLNLPTLVEELPMVQRRC" FT CDS complement(188543..189508) FT /transl_table=11 FT /locus_tag="Rv2955c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2955c, (MTCY349.34), len: 321 aa. Conserved FT hypothetical protein, similar to others e.g. Q98NV5|MLL9724 FT HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium FT loti) (284 aa), FASTA scores: opt: 231, E(): 6.5e-08, FT (34.6% identity in 182 aa overlap); Q9AGG2|NLPE1 NLPE1 from FT Rhizobium etli (249 aa), FASTA scores: opt: 212, E(): FT 1.1e-06, (27.85% identity in 255 aa overlap); Q9KXY2 FT HYPOTHETICAL 31.3 KDA PROTEIN from Streptomyces FT coelicolor(291 aa), FASTA scores: opt: 211, E(): 1.4e-06, FT (30.9% identity in 249 aa overlap); etc." FT /db_xref="InterPro:IPR006342" FT /db_xref="UniProtKB/TrEMBL:P95137" FT /protein_id="CAB05421.1" FT /translation="MQFQDVRLMRVVVCRRLGPAKGQRRWRPLDLGTTGCFENLGAQRP FT TYRMRAIRMLECAMPNRLVRSLQRWRPFGLPPHRWRLAPWYWRGLQVTLEPGSAIAWIV FT RLTGGFEETEIDIAAALYSALYPDRCILDVGANVGIHSLAWARLAPVVALEPAPGTHSR FT LEANVAANGLQDRIRTLRTAAGDAVGEVDFFVAADSAFSSLNDTGRIRIRERTRVPCTT FT LDALAAELPLPVGLLKIDVEGLERAVIAGAAELLRRDRPVLLVEIYGGAASNPDPERTI FT ADIRAYGYEPFVYADDAGLQPYQRHRDDRYCYFFIPSRKG" FT CDS 189631..190362 FT /transl_table=11 FT /locus_tag="Rv2956" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2956, (MTCY349.33c), len: 243 aa. Conserved FT hypothetical protein, highly similar to O86299|GSC GSC FT PROTEIN from Mycobacterium avium subsp. silvaticum FT Mycobacterium avium (240 aa), FASTA scores: opt: 1070, E(): FT 3.5e-63, (67.5% identity in 240 aa overlap); and O86294|GSC FT GSC PROTEIN from Mycobacterium paratuberculosis (240 aa), FT FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in FT 240 aa overlap). Also some similarity with other proteins FT from other organisms e.g. Q9L727 NODULATION PROTEIN NOEI FT from Rhizobium fredii (Sinorhizobium fredii) (241 aa), FT FASTA scores: opt: 205, E(): 3.5e-06, (27.25% identity in FT 198 aa overlap); Q9AGG1|LPEA LPEA PROTEIN from Rhizobium FT etli (286 aa), FASTA scores: opt: 201, E(): 7.2e-06, FT (28.85% identity in 208 aa overlap); P74191|SLL1173 FT HYPOTHETICAL 28.0 KDA PROTEIN Synechocystis sp. (strain PCC FT 6803) (244 aa), FASTA scores: opt: 274, E(): 1e-10, (30.65% FT identity in 225 aa overlap); etc. Also highly similar to FT others from Mycobacterium tuberculosis e.g. FT P71792|RV1513|MTCY277.35 HYPOTHETICAL 26.7 KDA PROTEIN (243 FT aa), FASTA scores: opt: 1105, E(): 1.7e-65, (70.05% FT identity in 237 aa overlap); etc." FT /db_xref="InterPro:IPR006342" FT /db_xref="UniProtKB/TrEMBL:P95136" FT /protein_id="CAB05420.1" FT /translation="MKSLKLARFIARSAAFEVSRRYSERDLKHQFVKQLKSRRVDVVFD FT VGANSGQYAAGLRRAAYKGRIVSFEPLSGPFTILESKASTDPLWDCRQHALGDSDGTVT FT INIAGNAGQSSSVLPMLKSHQNAFPPANYVGTQEASIHRLDSVAPEFLGMNGVAFLKVD FT VQGFEKQVLAGGKSTIDDHCVGMQLELSFLPLYEGGMLIPEALDLVYSLGFTLTGLLPC FT FIDANNGRMLQADGIFFREDD" FT CDS 190433..191260 FT /transl_table=11 FT /locus_tag="Rv2957" FT /product="POSSIBLE GLYCOSYL TRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="2.4.1.-" FT /note="Rv2957, (MTCY349.31c), len: 275 aa. Possible FT glycosyl transferase (EC 2.4.1.-); possibly secreted FT protein. Highly similar to O88109|GSD|GTFD GSD PROTEIN from FT Mycobacterium avium subsp. silvaticum, Mycobacterium FT paratuberculosis, and Mycobacterium avium (266 aa), FASTA FT scores: opt: 1010, E(): 2.5e-62, (68.8% identity in 221 aa FT overlap). Also some similarity with other proteins and FT especially glycosyl transferases e.g. Q9AEE4 HYPOTHETICAL FT 31.4 KDA PROTEIN from Leptospira interrogans (265 aa), FT FASTA scores: opt: 371, E(): 3.3e-18, (34.43% identity in FT 212 aa overlap); Q9EXY4 PUTATIVE GLYCOSYL TRANSFERASE from FT Escherichia coli (248 aa), FASTA scores: opt: 339, E(): FT 5e-16, (32.4% identity in 210 aa overlap); Q9RCC4 FT GLYCOSYLTRANSFERASE-LIKE PROTEIN from Yersinia pestis (247 FT aa), FASTA scores: opt: 333, E(): 1.3e-15, (31.8% identity FT in 217 aa overlap); Q9EXY1 PUTATIVE GLYCOSYL TRANSFERASE FT from Escherichia coli (248 aa), FASTA scores: opt: 328, FT E(): 2.9e-15, (31.9% identity in 210 aa overlap); etc. FT Equivalent to AAK47357 from Mycobacterium tuberculosis FT strain CDC1551 (256 aa) but longer 19 aa." FT /db_xref="GOA:P0A599" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/Swiss-Prot:P0A599" FT /protein_id="CAB05419.1" FT /translation="MVQTKRYAGLTAANTKKVAMAAPMFSIIIPTLNVAAVLPACLDSI FT ARQTCGDFELVLVDGGSTDETLDIANIFAPNLGERLIIHRDTDQGVYDAMNRGVDLATG FT TWLLFLGADDSLYEADTLARVAAFIGEHEPSDLVYGDVIMRSTNFRWGGAFDLDRLLFK FT RNICHQAIFYRRGLFGTIGPYNLRYRVLADWDFNIRCFSNPALVTRYMHVVVASYNEFG FT GLSNTIVDKEFLKRLPMSTRLGIRLVIVLVRRWPKVISRAMVMRTVISWRRRR" FT CDS complement(191677..192963) FT /transl_table=11 FT /locus_tag="Rv2958c" FT /product="POSSIBLE GLYCOSYL TRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM. POSSIBLY INVOLVED IN RESISTANCE TO KILLING BY FT HUMAN MACROPHAGES." FT /EC_number="2.4.1.-" FT /note="Rv2958c, (MTCY349.30), len: 428 aa. Possible FT glycosyl transferase (EC 2.4.1.-) (see citation below), FT highly similar to Q9CD88|ML0128 PUTATIVE GLYCOSYL FT TRANSFERASE from Mycobacterium leprae (435 aa), FASTA FT scores: opt: 2116, E(): 5.8e-126, (75.05% identity in 417 FT aa overlap); and Q9CD91|ML0125 PUTATIVE GLYCOSYL FT TRANSFERASE from Mycobacterium leprae (438 aa), FASTA FT scores: opt: 2104, E(): 3.3e-125, (74.65% identity in 418 FT aa overlap). Also shows some similarity to variety of FT glycosyl transferases e.g. Q9RYI3 PUTATIVE FT GLYCOSYLTRANSFERASE from Deinococcus radiodurans (418 aa), FT FASTA scores: opt: 317, E(): 1.9e-12, (31.0% identity in FT 297 aa overlap); Q9S1V2 PUTATIVE GLYCOSYL TRANSFERASE from FT Streptomyces coelicolor (407 aa), FASTA scores: opt: 264, FT E(): 4.1e-09, (27.2% identity in 342 aa overlap); FT P72650|CRTX|SLR1125 ZEAXANTHIN GLUCOSYL TRANSFERASE from FT Synechocystis sp. strain PCC 6803 (419 aa), FASTA scores: FT opt: 251, E(): 2.8e-08, (26.8% identity in 295 aa overlap); FT etc. Very similar to P95130|MTCY349.25 from Mycobacterium FT tuberculosis (449 aa), FASTA score: opt: 2215, E(): FT 3.3e-132, (77.25% identity in 422 aa overlap)." FT /db_xref="GOA:P95134" FT /db_xref="InterPro:IPR002213" FT /db_xref="UniProtKB/Swiss-Prot:P95134" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05418.1" FT /translation="MEETSVAGDPGPDAGTSTAPNAAPEPVARRQRILFVGEAATLAHV FT VRPFVLARSLDPSRYEVHFACDPRFNKLLGPLPFPHHPIHTVPSEEVLLKIAQGRLFYN FT TRTLRKYIAADRKILNEIAPDVVVGDNRLSLSVSARLAGIPYIAIANAYWSPQARRRFP FT LPDVPWTRFFGVRPVSILYRLYRPLIFALYCLPLNWLRRKHGLSSLGWDLCRIFTDGDY FT TLYADVPELVPTYNLPANHRYLGPVLWSPDVKPPTWWHSLPTDRPIIYATLGSSGGKNL FT LQVVLNALADLPVTVIAATAGRNHLKNVPANAFVADYLPGEAAAARSAVVLCNGGSPTT FT QQALAAGVPVIGLPSNMDQHLNMEALERAGAGVLLRTERLNTEGVAAAVKQVLSGAEFR FT QAARRLAEAFGPDFAGFPQHIESALRLVC" FT CDS complement(193064..193801) FT /transl_table=11 FT /locus_tag="Rv2959c" FT /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" FT /function="THOUGHT TO CAUSE METHYLATION." FT /EC_number="2.1.1.-" FT /note="Rv2959c, (MTCY349.29), len: 245 aa. Possible FT methyltransferase (EC 2.1.1.-), highly similar to FT Q9CD89|ML0127 from Mycobacterium leprae (229 aa), FASTA FT scores: opt: 1183, E(): 3.9e-69, (76.1% identity in 226 aa FT overlap). Also some similarity with other FT methyltransferases and other proteins e.g. Q51079 PUTATIVE FT METHYL TRANSFERASE from Nocardia lactamdurans (236 aa), FT FASTA scores: opt: 156, E(): 0.0086, (23.25% identity in FT 159 aa overlap); Q98ID5 CEPHALOSPORIN HYDROXYLASE from FT Rhizobium loti (Mesorhizobium loti) (217 aa), FASTA scores: FT opt: 275, E(): 1.7e-10, (29.65% identity in 199 aa FT overlap); etc. And also similar to P72897 HYPOTHETICAL 27.8 FT KDA PROTEIN from Mycobacterium tuberculosis (249 aa), FASTA FT scores: opt: 292, E(): 1.5e-11, (31.25% identity in 208 aa FT overlap)." FT /db_xref="GOA:Q50457" FT /db_xref="InterPro:IPR007072" FT /db_xref="UniProtKB/Swiss-Prot:Q50457" FT /protein_id="CAB05417.1" FT /translation="MGLVWRSRTSLVGQLIGLVRLVASFAAQLFYRPSDAVAEEYHKWY FT YGNLVWTKTTYMGINCWKSVSDMWNYQEILSELQPSLVIEFGTRYGGSAVYFANIMRQI FT GQPFKVLTVDNSHKALDPRARREPDVLFVESSSTDPAIAEQIQRLKNEYPGKIFAILDS FT DHSMNHVLAEMKLLRPLLSAGDYLVVEDSNINGHPVLPGFGPGPYEAIEAYEDEFPNDY FT KHDAERENKFGWTSAPNGFLIRN" FT CDS complement(193916..194164) FT /transl_table=11 FT /locus_tag="Rv2960c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2960c, (MT3036, MTCY349.28), len: 82 aa. FT Hypothetical unknown protein, equivalent to AAK47362 from FT Mycobacterium tuberculosis strain CDC1551 (116 aa) but FT shorter 34 aa. Shortened version of MTCY349.28 avoiding FT overlap." FT /db_xref="UniProtKB/TrEMBL:P95133" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05442.1" FT /translation="MGRNATAVVSLPVVALSPRAGQAGYLWQSITRGLRVTPICCYHPP FT CGGGVQKMLSRKLGRVCPAPSPKDAARGAHNVGANAV" FT CDS 194246..194635 FT /transl_table=11 FT /locus_tag="Rv2961" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF AN INSERTION FT ELEMENT." FT /note="Rv2961, (MTCY349.26c), len: 129 aa. Probable FT transposase, highly similar to C-terminus of FT O50414|Rv3387|MTV004.45 PUTATIVE TRANSPOSASE from FT Mycobacterium tuberculosis (225 aa), FASTA scores: opt: FT 605, E(): 7.2e-34, (66.65% identity in 129 aa overlap); and FT similar to others e.g. CAC47401 PUTATIVE PARTIAL FT TRANSPOSASE FOR ISRM17 PROTEIN from Rhizobium meliloti FT (Sinorhizobium meliloti) (174 aa), FASTA scores: opt: 183, FT E(): 2.6e-05, (30.25% identity in 129 aa overlap); etc." FT /db_xref="UniProtKB/TrEMBL:P95131" FT /protein_id="CAB05416.1" FT /translation="MEHGNPHDAPQLAPAVERITTRAGRPPGTVTADRGYGEKRVEDDL FT HDLGVRTVAIPRKGRPSQARRAEEQRPSFRRTVKWRTGSEGRISTLKRNYGWNRSCIDG FT TEGTRIWTRHGILTHNLIKISSLAA" FT CDS complement(194736..196085) FT /transl_table=11 FT /locus_tag="Rv2962c" FT /product="POSSIBLE GLYCOSYL TRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM. POSSIBLY INVOLVED IN RESISTANCE TO KILLING BY FT HUMAN MACROPHAGES." FT /EC_number="2.4.1.-" FT /note="Rv2962c, (MTCY349.25), len: 508 aa. Possible FT glycosyl transferase (EC 2.4.1.-) (see citation below), FT highly similar or identical to Mycobacterium tuberculosis FT proteins G560522 U0002JA, G560521 U0002H, G560522 U0002JA, FT G560519 U0002KA. Equivalent (but longer 21 aa) to Q9CD91 FT PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae FT (438 aa), FASTA scores: opt: 2229, E(): 1.3e-133, (77.45% FT identity in 426 aa overlap); and highly similar to Q9CD88 FT PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae FT (435 aa), FASTA scores: opt: 2129, E(): 2.7e-127, (74.35% FT identity in 425 aa overlap); and others from Mycobacterium FT leprae. Also shows some similarity to variety of glycosyl FT transferases e.g. Q9RYI3|DRA0329 PUTATIVE GLYCOSYL FT TRANSFERASE from Deinococcus radiodurans (418 aa), FASTA FT scores: opt: 340, E(): 5.5e-14, (31.2% identity in 330 aa FT overlap); P72650 ZEAXANTHIN GLUCOSYL TRANSFERASE from FT Synechocystis sp. (strain PCC 6803) (419 aa), FASTA scores: FT opt: 244, E(): 6.6e-08, (26.2% identity in 294 aa overlap); FT etc. Also highly similar to P95134 HYPOTHETICAL 46.8 KDA FT PROTEIN from Mycobacterium tuberculosis (428 aa), FASTA FT scores: opt: 2215, E(): 9.6e-133, (77.25% identity in 422 FT aa overlap)." FT /db_xref="GOA:P95130" FT /db_xref="InterPro:IPR002213" FT /db_xref="UniProtKB/Swiss-Prot:P95130" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05415.1" FT /translation="MRVSCVYATASRWGGPPVASEVRGDAAISTTPDAAPGLAARRRRI FT LFVAEAVTLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLPFRHHAIHTIPSERF FT FGNLTQGRFYAMRTLRKYVEADLRVLDEIAPDLVVGDLRISLSVSARLAGIPYIAIANA FT YWSPYAQRRFPLPDVIWTRLFGVRLVKLLYRLERPLLFALQCMPLNWVRRRHGLSSLGW FT NLCRIFTDGDHTLYADVPELMPTYDLPANHEYLGPVLWSPAGKPPTWWDSLPTDRPIVY FT ATLGTSGGRNLLQLVLNALAELPVTVIAATAGRSDLKTVPANAFVADYLPGEAAAARSA FT VVVCNGGSLTTQQALVAGVPVIGVAGNLDQHLNMEAVERAGAGVLLRTERLKSQRVAGA FT VMQVISRSEYRQAAARLADAFGRDRVGFPQHVENALRLMPENRPRTWLAS" FT CDS 196199..197419 FT /transl_table=11 FT /locus_tag="Rv2963" FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2963, (MTCY349.24c), len: 406 aa. Probable FT integral membrane protein." FT /db_xref="InterPro:IPR005524" FT /db_xref="UniProtKB/TrEMBL:P95129" FT /protein_id="CAB05414.1" FT /translation="MTSTKVEDRVTAAVLGAIGHALALTASMTWEILWALILGFALSAV FT VQAVVRRSTIVTLLGDDRPRTLVIATGLGAASSSCSYAAVALARSLFRKGANFTAAMAF FT EIGSTNLVVELGIILALLMGWQFTAAEFVGGPIMILVLAVLFRLFVGARLIDAAREQAE FT RGLAGSMEGHAAMDMSIKREGSFWRRLLSPPGFTSIAHVFVMEWLAILRDLILGLLIAG FT AIAAWVPESFWQSFFLANHPAWSAVWGPIIGPIVAIVSFVCSIGNVPLAAVLWNGGISF FT GGVIAFIFADLLILPILNIYRKYYGARMMLVLLGTFYASMVVAGYLIELLFGTTNLIPS FT QRSATVMTAEISWNYTTWLNVIFLVIAAALVVRFITSGGLPMLRMMGGSPDAPHDHHDR FT HDDHLGH" FT CDS 197492..198424 FT /transl_table=11 FT /gene="purU" FT /locus_tag="Rv2964" FT /product="PROBABLE FORMYLTETRAHYDROFOLATE DEFORMYLASE PURU FT (FORMYL-FH(4) HYDROLASE)" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS FT [CATALYTIC ACTIVITY: 10-FORMYLTETRAHYDROFOLATE + H(2)O = FT FORMATE + TETRAHYDROFOLATE]." FT /EC_number="3.5.1.10" FT /note="Rv2964, (MTCY349.23c), len: 310 aa. Probable purU, FT formyltetrahydrofolate deformylase (EC 3.5.1.10), highly FT similar to others e.g. Q9RWT1|DR0584 FORMYLTETRAHYDROFOLATE FT DEFORMYLASE from Deinococcus radiodurans (298 aa), FASTA FT scores: opt: 1005, E(): 4.9e-52, (52.25% identity in 297 aa FT overlap); Q9K7U4 FORMYLTETRAHYDROFOLATE DEFORMYLASE from FT Bacillus halodurans (289 aa), FASTA scores: opt: 982, E(): FT 1.1e-50, (51.8% identity in 280 aa overlap); FT Q55135|PURU_SYNY3|SLL0070 FORMYLTETRAHYDROFOLATE FT DEFORMYLASE from Synechocystis sp. strain PCC 6803 (284 FT aa), FASTA scores: opt: 839, E(): 2.9e-42, (48.2% identity FT in 280 aa overlap); etc." FT /db_xref="GOA:P0A5T6" FT /db_xref="InterPro:IPR004810" FT /db_xref="UniProtKB/Swiss-Prot:P0A5T6" FT /protein_id="CAB05413.1" FT /translation="MGKGSMTAHATPNEPDYPPPPGGPPPPADIGRLLLRCHDRPGIIA FT AVSTFLARAGANIISLDQHSTAPEGGTFLQRAIFHLPGLTAAVDELQRDFGSTVADKFG FT IDYRFAEAAKPKRVAIMASTEDHCLLDLLWRNRRGELEMSVVMVIANHPDLAAHVRPFG FT VPFIHIPATRDTRTEAEQRQLQLLSGNVDLVVLARYMQILSPGFLEAIGCPLINIHHSF FT LPAFTGAAPYQRARERGVKLIGATAHYVTEVLDEGPIIEQDVVRVDHTHTVDDLVRVGA FT DVERAVLSRAVLWHCQDRVIVHHNQTIVF" FT CDS complement(199293..199778) FT /transl_table=11 FT /gene="kdtB" FT /locus_tag="Rv2965c" FT /standard_name="coaD" FT /product="PROBABLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE FT KDTB (PANTETHEINE-PHOSPHATE ADENYLYLTRANSFERASE) (PPAT) FT (DEPHOSPHO-CoA PYROPHOSPHORYLASE)" FT /function="INVOLVED IN THE COENZYME A (CoA) BIOSYNTHESIS FT (AT THE FOURTH STEP). REVERSIBLY TRANSFERS AN ADENYLYL FT GROUP FROM ATP TO 4'-PHOSPHOPANTETHEINE, YIELDING FT DEPHOSPHO-CoA (DPCOA) AND PYROPHOSPHATE [CATALYTIC FT ACTIVITY: ATP + PANTETHEINE 4'-PHOSPHATE = DIPHOSPHATE + FT DEPHOSPHO-CoA]." FT /EC_number="2.7.7.3" FT /note="Rv2965c, (MTCY349.22), len: 161 aa. Probable kdtB FT (alternate gene name: coaD), phosphopantetheine FT adenylyltransferase (EC 2.7.7.3), equivalent to FT O69466|COAD_MYCLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE FT from Mycobacterium leprae (160 aa), FASTA scores: opt: 881, FT E(): 2.5e-54, (84.1% identity in 157 aa overlap). Also FT highly similar to others e.g. Q9ZBR1|COAD_STRCO from FT Streptomyces coelicolor (159 aa), FASTA scores: opt: 575, FT E(): 5.8e-33, (54.1% identity in 159 aa overlap); FT Q9WZK0|COAD_THEMA from Thermotoga maritima (161 aa), FASTA FT scores: opt: 509, E(): 2.4e-28, (50.0% identity in 154 aa FT overlap); P23875|COAD_ECOLICOAD|KDTB|B3634|Z5058|ECS4509 FT from Escherichia coli strain O157:H7 and K12 (159 aa), FT FASTA scores: opt: 459, E(): 7.3e-25, (45.15% identity in FT 155 aa overlap); etc. BELONGS TO THE COAD FAMILY." FT /db_xref="GOA:P0A530" FT /db_xref="InterPro:IPR014729" FT /db_xref="PDB:1TFU" FT /db_xref="UniProtKB/Swiss-Prot:P0A530" FT /protein_id="CAB05412.1" FT /translation="MTGAVCPGSFDPVTLGHVDIFERAAAQFDEVVVAILVNPAKTGMF FT DLDERIAMVKESTTHLPNLRVQVGHGLVVDFVRSCGMTAIVKGLRTGTDFEYELQMAQM FT NKHIAGVDTFFVATAPRYSFVSSSLAKEVAMLGGDVSELLPEPVNRRLRDRLNTERT" FT repeat_region complement(199798..199852) FT /note="55 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT CDS complement(199864..200430) FT /transl_table=11 FT /locus_tag="Rv2966c" FT /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" FT /function="THOUGHT TO CAUSE METHYLATION." FT /EC_number="2.1.1.-" FT /note="Rv2966c, (MTCY349.21), len: 188 aa. Possible FT methyltransferase (EC 2.1.1.-), equivalent (but shorter 36 FT aa) to O69465|MLCB1243.09 HYPOTHETICAL 23.0 KDA PROTEIN FT from Mycobacterium leprae (220 aa), FASTA scores: opt: 872, FT E(): 9.1e-50, (74.2% identity in 182 aa overlap). Also FT similar to others e.g. Q9ZBR2|SC7A1.11 PUTATIVE METHYLASE FT from Streptomyces coelicolor (195 aa), FASTA scores: opt: FT 510, E(): 3.7e-26, (47.5% identity in 179 aa overlap); FT Q9F842 HYPOTHETICAL METHYLTRANSFERASE (FRAGMENT) from FT Mycobacterium smegmatis (80 aa), FASTA scores: opt: 386, FT E(): 2.5e-18, (75.0% identity in 80 aa overlap); FT P10120|YHHF_ECOLI|YHHFZ|B3465 PUTATIVE METHYLASE from FT Escherichia colistrain K12 (198 aa), FASTA scores: opt: FT 319, E(): 1.1e-13, (35.5% identity in 183 aa overlap); etc. FT Contains PS00092 N-6 Adenine-specific DNA methylases FT signature." FT /db_xref="GOA:P95128" FT /db_xref="InterPro:IPR016065" FT /db_xref="UniProtKB/TrEMBL:P95128" FT /protein_id="CAB05411.1" FT /translation="MTRIIGGVAGGRRIAVPPRGTRPTTDRVRESLFNIVTARRDLTGL FT AVLDLYAGSGALGLEALSRGAASVLFVESDQRSAAVIARNIEALGLSGATLRRGAVAAV FT VAAGTTSPVDLVLADPPYNVDSADVDAILAALGTNGWTREGTVAVVERATTCAPLTWPE FT GWRRWPQRVYGDTRLELAERLFANV" FT misc_feature complement(200065..200085) FT /note="PS00092 N-6 Adenine-specific DNA methylases FT signature" FT repeat_region complement(200431..200531) FT /note="101 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT repeat_region complement(200532..200629) FT /note="98 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT CDS complement(200626..204009) FT /transl_table=11 FT /gene="pca" FT /locus_tag="Rv2967c" FT /product="PROBABLE PYRUVATE CARBOXYLASE PCA (PYRUVIC FT CARBOXYLASE)" FT /function="INVOLVED IN GLUCONEOGENESIS AND LIPOGENESIS. FT PYRUVATE CARBOXYLASE CATALYZES A 2-STEP REACTION, INVOLVING FT THE ATP-DEPENDENT CARBOXYLATION OF THE COVALENTLY ATTACHED FT BIOTIN IN THE FIRST STEP AND THE TRANSFER OF THE CARBOXYL FT GROUP TO PYRUVATE IN THE SECOND [CATALYTIC ACTIVITY: ATP + FT PYRUVATE + HCO(3)(-) = ADP + PHOSPHATE + OXALOACETATE]." FT /EC_number="6.4.1.1" FT /note="Rv2967c, (MTCY349.20), len: 1127 aa. Probable pca, FT pyruvate carboxylase (ala-rich protein) (EC 6.4.1.1), FT equivalent to Q9F843|PYC PYRUVATE CARBOXYLASE from FT Mycobacterium smegmatis (1127 aa), FASTA scores: opt: 6232, FT E(): 0, (83.3% identity in 1127 aa overlap). Also highly FT similar to others e.g. Q9RK64|SCF11.26c PYRUVATE FT CARBOXYLASE from Streptomyces coelicolor (1124 aa), FASTA FT scores: opt: 5526, E(): 0, (74.65% identity in 1125 aa FT overlap); O54587|PYC PYRUVATE CARBOXYLASE from FT Corynebacterium glutamicum (Brevibacterium flavum) (1140 FT aa), FASTA scores: opt: 4811, E(): 0, (64.5% identity in FT 1132 aa overlap); Q9DDT1 PYRUVATE CARBOXYLASE from FT Brachydanio rerio (Zebrafish) (1180 aa), FASTA scores: opt: FT 3133, E(): 1.1e-171, (47.8% identity in 1142 aa overlap); FT etc. Contains PS00867 Carbamoyl-phosphate synthase FT subdomain signature 2, PS00165 Serine/threonine FT dehydratases pyridoxal-phosphate attachment site, and FT PS00188 Biotin-requiring enzymes attachment site." FT /db_xref="GOA:P95127" FT /db_xref="HSSP:1A6X" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/TrEMBL:P95127" FT /protein_id="CAB05410.1" FT /translation="MFSKVLVANRGEIAIRAFRAAYELGVGTVAVYPYEDRNSQHRLKA FT DESYQIGDIGHPVHAYLSVDEIVATARRAGADAIYPGYGFLSENPDLAAACAAAGISFV FT GPSAEVLELAGNKSRAIAAAREAGLPVLMSSAPSASVDELLSVAAGMPFPLFVKAVAGG FT GGRGMRRVGDIAALPEAIEAASREAESAFGDPTVYLEQAVINPRHIEVQILADNLGDVI FT HLYERDCSVQRRHQKVIELAPAPHLDAELRYKMCVDAVAFARHIGYSCAGTVEFLLDER FT GEYVFIEMNPRVQVEHTVTEEITDVDLVASQLRIAAGETLEQLGLRQEDIAPHGAALQC FT RITTEDPANGFRPDTGRISALRTAGGAGVRLDGSTNLGAEISPYFDSMLVKLTCRGRDL FT PTAVSRARRAIAEFRIRGVSTNIPFLQAVLDDPDFRAGRVTTSFIDERPQLLTARASAD FT RGTKILNFLADVTVNNPYGSRPSTIYPDDKLPDLDLRAAPPAGSKQRLVKLGPEGFARW FT LRESAAVGVTDTTFRDAHQSLLATRVRTSGLSRVAPYLARTMPQLLSVECWGGATYDVA FT LRFLKEDPWERLATLRAAMPNICLQMLLRGRNTVGYTPYPEIVTSAFVQEATATGIDIF FT RIFDALNNIESMRPAIDAVRETGSAIAEVAMCYTGDLTDPGEQLYTLDYYLKLAEQIVD FT AGAHVLAIKDMAGLLRPPAAQRLVSALRSRFDLPVHLHTHDTPGGQLASYVAAWHAGAD FT AVDGAAAPLAGTTSQPALSSIVAAAAHTEYDTGLSLSAVCALEPYWEALRKVYAPFESG FT LPGPTGRVYHHEIPGGQLSNLRQQAIALGLGDRFEEIEEAYAGADRVLGRLVKVTPTSK FT VVGDLALALVGAGVSADEFASDPARFGIPESVLGFLRGELGDPPGGWPEPLRTAALAGR FT GAARPTAQLAADDEIALSSVGAKRQATLNRLLFPSPTKEFNEHREAYGDTSQLSANQFF FT YGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCILNGQLRPVLVRDRSIASAV FT PAAEKADRGNPGHIAAPFAGVVTVGVCVGERVGAGQTIATIEAMKMEAPITAPVAGTVE FT RVAVSDTAQVEGGDLLVVVS" FT misc_feature complement(200710..200763) FT /note="PS00188 Biotin-requiring enzymes attachment site" FT misc_feature complement(201889..201930) FT /note="PS00165 Serine/threonine dehydratases FT pyridoxal-phosphate attachment site" FT misc_feature complement(203131..203154) FT /note="PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2" FT CDS complement(204034..204666) FT /transl_table=11 FT /locus_tag="Rv2968c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2968c, (MTCY349.19), len: 210 aa. Probable FT conserved integral membrane protein, equivalent to O69464 FT PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium FT leprae (214 aa), FASTA scores: opt: 1060, E(): 1.4e-58, FT (71.95% identity in 214 aa overlap). Also highly similar to FT others e.g. Q9F844 HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT from Mycobacterium smegmatis (187 aa), FASTA scores: opt: FT 883, E(): 1.2e-47, (62.8% identity in 190 aa overlap); FT Q9KXP3 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces FT coelicolor (240 aa), FASTA scores: opt: 503, E(): 4.6e-24, FT (38.0% identity in 192 aa overlap); etc." FT /db_xref="InterPro:IPR012932" FT /db_xref="UniProtKB/TrEMBL:P95126" FT /protein_id="CAB05409.1" FT /translation="MVAARPAERSGDPAAVRVPVPSAWWVLIGGVIGLFASMTLTVEKV FT RILLDPIYVPSCNVNPIVSCGSVMTTPQASLLGFPNPLLGIAGFTVVVVTGVLAVAKVP FT LPRWYWIGLAVGILVGVAFVHWLIFQSLYRIGALCPYCMVVWAVIATLLVVVASIVFGP FT MRENRGSQERVGARLLYQWRWSLATLWFTTVFLLIMVRFWDYWSTLI" FT CDS complement(204672..205439) FT /transl_table=11 FT /locus_tag="Rv2969c" FT /product="POSSIBLE CONSERVED MEMBRANE OR SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv2969c, (MTCY349.18), len: 255 aa. Possible FT conserved membrane or exported protein, equivalent to FT Q9CBS4|ML1667 POSSIBLE CONSERVED MEMBRANE PROTEIN from FT Mycobacterium leprae (264 aa), FASTA scores: opt: 1101, FT E(): 9.9e-68, (65.9% identity in 258 aa overlap); and FT highly similar to O69463 PUTATIVE TRANSMEMBRANE PROTEIN FT from Mycobacterium leprae (258 aa), FASTA scores: opt: FT 1097, E(): 1.8e-67, (65.5% identity in 258 aa overlap). FT C-terminus also highly similar to Q9KK65|996A160 EXPORTED FT PROTEIN (FRAGMENT) from Mycobacterium avium (85 aa), FASTA FT scores: opt: 418, E(): 2e-21, (72.95% identity in 85 aa FT overlap). Also weakly similar to membrane or exported FT proteins e.g. Q9S2U7|SC4G6.04c PUTATIVE INTEGRAL MEMBRANE FT PROTEIN from Streptomyces coelicolor (275 aa), FASTA FT scores: opt: 312, E(): 7.6e-14, (28.25% identity in 230 aa FT overlap); Q9XAB6|SCC22.22C PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (255 aa), FASTA scores: opt: 181, FT E(): 6.4e-05, (27.0% identity in 226 aa overlap); etc. Also FT some similarity with P72001|PKNE_MYCTU from Mycobacterium FT tuberculosis (566 aa), FASTA scores: opt: 264, E(): FT 2.3e-10, (30.5% identity in 177 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O33272" FT /protein_id="CAB05408.1" FT /translation="MADKSKRPPRFDLKSADGSFGRLVQIGGTTIVVVFAVVLVFYIVT FT SRDDKKDGVAGPGDAVRVTSSKLVTQPGTSNPKAVVSFYEDFLCPACGIFERGFGPTVS FT KLVDIGAVAADYTMVAILDSASNQHYSSRAAAAAYCVADESIEAFRRFHAALFSKDIQP FT AELGKDFPDNARLIELAREAGVVGKVPDCINSGKYIEKVDGLAAAVNVHATPTVRVNGT FT EYEWSTPAALVAKIKEIVGDVPGIDSAAATATS" FT CDS complement(205536..206666) FT /transl_table=11 FT /gene="lipN" FT /locus_tag="Rv2970c" FT /product="PROBABLE LIPASE/ESTERASE LIPN" FT /function="UNKNOWN; LIPOLYTIC ENZYME INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="3.1.1.-" FT /note="Rv2970c, (MTCY349.17), len: 376 aa. Probable lipN, FT lipase/esterase (EC 3.1.1.-), similar to others e.g. FT Q9AA37|CC0771 PUTATIVE ESTERASE from Caulobacter crescentus FT (380 aa), FASTA scores: opt: 822, E(): 8e-46, (42.15% FT identity in 318 aa overlap); Q9XDR4 ESTERASE HDE from FT petroleum-degrading bacterium HD-1 (317 aa), FASTA scores: FT opt: 738, E(): 2e-40, (48.85% identity in 262 aa overlap); FT O52270 LIPASE from Pseudomonas sp. (strain B11-1) (308 aa), FT FASTA scores: opt: 683, E(): 7.3e-37, (41.3% identity in FT 288 aa overlap); etc. Also similar to P71668 HYPOTHETICAL FT 34.1 KDA PROTEIN from Mycobacterium tuberculosis (320 aa), FT FASTA scores: opt: 715, E(): 6.3e-39, (42.3% identity in FT 298 aa overlap). Equivalent to AAK47374 from Mycobacterium FT tuberculosis strain CDC1551 (309 aa) but longer 67 aa." FT /db_xref="GOA:P95125" FT /db_xref="HSSP:1JJI" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:P95125" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05441.1" FT /translation="MTKSLPGVADLRLGANHPRMWTRRVQGTVVNVGVKVLPWIPTPAK FT RILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDDIVASRAHMRAICEAMPGPQ FT IHVDVTDLSIPGPAGEIPARHYRPSGGGATPLLVFYHGGGWTLGDLDTHDALCRLTCRD FT ADIQVLSIDYRLAPEHPAPAAVEDAYAAFVWAHEHASDEFGALPGRVAVGGDSAGGNLS FT AVVCQLARDKARYEGGPTPVLQWLLYPRTDFTAQTRSMGLFGNGFLLTKRDIDWFHTQY FT LRDSDVDPADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLRY FT LGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV" FT CDS 206897..207067 FT /transl_table=11 FT /locus_tag="Rv2970A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2970A, len: 56 aa. Conserved hypothetical protein, FT similar to C-terminal part of several oxidoreductases e.g. FT Rv2971|Z83018|MTCY349_22 from Mycobacterium tuberculosis FT (282 aa), FASTA scores: opt: 158, E(): 3.6e-06, (45.0% FT identity in 60 aa overlap). May represent a gene fragment." FT /protein_id="CAE55533.1" FT /translation="MLIRWHIQLGNIVIPKSVNPMRIASNFDAFDFPRSMTEPGLVRIR FT KPSISQAGEMT" FT CDS 207064..207912 FT /transl_table=11 FT /locus_tag="Rv2971" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv2971, (MTCY349.16c), len: 282 aa. Probable FT oxidoreductase (EC 1.-.-.-), possibly aldo/keto reductase, FT equivalent to O69462 PUTATIVE OXIDOREDUCTASE from FT Mycobacterium leprae (282 aa), FASTA scores: opt: 1495, FT E(): 4.9e-93, (82.35% identity in 272 aa overlap). Also FT similar to others e.g. Q9KYM9|SC9H11.10C OXIDOREDUCTASE FT from Streptomyces coelicolor (276 aa), FASTA scores: opt: FT 849, E(): 1.2e-49, (51.7% identity in 267 aa overlap); FT Q9ZBW7|SC4B5.01C PUTATIVE OXIDOREDUCTASE from Streptomyces FT coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49, FT (49.1% identity in 271 aa overlap); FT Q46857|YQHE_ECOLI|YQHE|B3012 HYPOTHETICAL OXIDOREDUCTASE FT from Escherichia coli strain K12 (275 aa), FASTA scores: FT opt: 827, E(): 3.7e-48, (47.45% identity in 276 aa FT overlap); etc. Contains PS00063 Aldo /keto reductase family FT putative active site signature; and PS00062 Aldo/keto FT reductase family signature 2." FT /db_xref="GOA:P95124" FT /db_xref="HSSP:1HW6" FT /db_xref="InterPro:IPR018170" FT /db_xref="UniProtKB/Swiss-Prot:P95124" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB05440.1" FT /translation="MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALE FT IGCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRASLDRL FT GLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLTFVT FT PAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGRLLDNPTVTSIASEYVKTPAQV FT LLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTRVREDPLTYAG FT T" FT misc_feature 207454..207507 FT /note="PS00062 Aldo/keto reductase family signature 2" FT misc_feature 207766..207813 FT /note="PS00063 Aldo/keto reductase family putative active FT site signature" FT CDS complement(207986..208699) FT /transl_table=11 FT /locus_tag="Rv2972c" FT /product="POSSIBLE CONSERVED MEMBRANE OR EXPORTED PROTEIN" FT /function="UNKNOWN" FT /note="Rv2972c, (MTCY349.15), len: 237 aa. Possible FT conserved membrane or exported protein, equivalent (but FT longer 52 aa) to O69461|MLCB1243.02 HYPOTHETICAL 20.5 KDA FT PROTEIN from Mycobacterium leprae (180 aa), FASTA scores: FT opt: 581, E(): 8.2e-32, (55.75% identity in 174 aa FT overlap). Also similar to membrane or exported proteins FT e.g. Q9F2P3|SCE41.16C PUTATIVE LIPOPROTEIN from FT Streptomyces coelicolor (258 aa), FASTA scores: opt: 498, FT E(): 4.1e-26, (44.08% identity in 186 aa overlap); FT Q99QB5|SCP1.323C PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (219 aa), FASTA scores: opt: 329, FT E(): 8.5e-15, (36.35% identity in 176 aa overlap); FT Q9ACQ1|SCP1.267 PUTATIVE SECRETED PROTEIN from Streptomyces FT coelicolor (219 aa), FASTA scores: opt: 286, E(): 6.6e-12, FT (32.03% identity in 231 aa overlap); etc." FT /db_xref="InterPro:IPR018532" FT /db_xref="UniProtKB/TrEMBL:P95123" FT /protein_id="CAB05439.1" FT /translation="MNRRTLLWLSAIAALALVVAYQTLGSSAGRHADEFAARAGVPTVQ FT PGADVLAGIAVLPKRIHRYDYRRSAFGHPWDDRNDAPGGHNGCDTRDDILDRDLVDKTY FT VSIKRCPNAVATGTLRDPYTNTTVAFQRGASVGQSVQIDHIVPLSYAWDMGAYRWPNSE FT RMRFANDPANLLAVQGQANQDKGDSPPAQWMPPNKAFACQYAMQFIAVLRGYSLPVDQP FT SSDVLRQAAATCPTG" FT CDS complement(208696..210909) FT /transl_table=11 FT /gene="recG" FT /locus_tag="Rv2973c" FT /product="PROBABLE ATP-DEPENDENT DNA HELICASE RECG" FT /function="CRITICAL ROLE IN RECOMBINATION AND DNA REPAIR. FT HELP PROCESS HOLLIDAY JUNCTION INTERMEDIATES TO MATURE FT PRODUCTS BY CATALYSING BRANCH MIGRATION. HAS A DNA FT UNWINDING ACTIVITY CHARACTERISTIC OF A DNA HELICASE WITH A FT 3' TO 5' POLARITY. RECG UNWIND BRANCHED DUPLEX DNA FT (Y-DNA)." FT /EC_number="3.6.1.-" FT /note="Rv2973c, (MTCY349.14), len: 737 aa. Probable recG, FT ATP-dependent DNA helicase (EC 3.6.1.-) (see citation FT below), equivalent to O69460|RECG_MYCLE ATP-DEPENDENT DNA FT HELICASE from Mycobacterium leprae (743 aa), FASTA scores: FT opt: 3846, E(): 0, (79.3% identity in 744 aa overlap). Also FT highly similar to others e.g. Q9ZBR3|SC7A1.10 PUTATIVE FT ATP-DEPENDENT DNA HELICASE from Streptomyces coelicolor FT (742 aa), FASTA scores: opt: 1249, E(): 1.1e-67, (46.2% FT identity in 758 aa overlap); Q9PGE8 ATP-DEPENDENT DNA FT HELICASE from Xylella fastidiosa (718 aa), FASTA scores: FT opt: 1174, E(): 3.5e-63, (42.1% identity in 539 aa FT overlap); P24230|RECG_ECOLI|RECG|B3652 from Escherichia FT coli strain K12 (693 aa), FASTA scores: opt: 457, E(): FT 7.3e-22, (35.2% identity in 733 aa overlap); etc. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO FT THE HELICASE FAMILY, RECG SUBFAMILY." FT /db_xref="GOA:P64322" FT /db_xref="HSSP:1GM5" FT /db_xref="InterPro:IPR004365" FT /db_xref="UniProtKB/Swiss-Prot:P64322" FT /protein_id="CAB05438.1" FT /translation="MASLSDRLDRVLGATAADALDEQFGMRTVDDLLRHYPRSYVEGAA FT RVGIGDARPEAGEHITIVDVITDTYSFPMKKKPNRKCLRITVGGGRNKVTATFFNADYI FT MRDLTKHTKVMLSGEVGYYKGAMQLTHPAFLILDSPDGKNHGTRSLKSIADASKAISGE FT LVVEEFERRFFPIYPASTKVQSWDIFKCVRQVLDVLDRVDDPLPAELRAKHGLIPEDEA FT LRAIHLAESQSLRERARERLTFDEAVGLQWALVARRHGELSESGPSAAWKSNGLAAELL FT RRLPFELTAGQREVLDVLSDGLAANRPLNRLLQGEVGSGKTIVAVLAMLQMVDAGYQCA FT LLAPTEVLAAQHLRSIRDVLGPLAMGGQLGGAENATRVALLTGSMTAGQKKQVRAEIAS FT GQVGIVIGTHALLQEAVDFHNLGMVVVDEQHRFGVEQRDQLRAKAPAGITPHLLVMTAT FT PIPRTVALTVYGDLETSTLRELPLGRQPIATNVIFVKDKPAWLDRAWRRIIEEAAAGRQ FT AYVVAPRIDESDDTDVQGGVRPSATAEGLFSRLRSAELAELRLALMHGRLSADDKDAAM FT AAFRAGEVDVLVCTTVIEVGVDVPNATVMLVMDADRFGISQLHQLRGRIGRGEHPSVCL FT LASWVPPDTPAGQRLRAVAGTMDGFALADLDLKERKEGDVLGRNQSGKAITLRLLSLAE FT HEEYIVAARDFCIEAYKNPTDPALALMAARFTSTDRIEYLDKS" FT misc_feature complement(209944..209967) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(210912..212324) FT /transl_table=11 FT /locus_tag="Rv2974c" FT /product="CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2974c, (MTCY349.13), len: 470 aa. Conserved FT hypothetical ala-rich protein, highly similar to others FT e.g. C-terminus of Q9ZBR4|SC7A1.09 HYPOTHETICAL 59.5 KDA FT PROTEIN from Streptomyces coelicolor (589 aa), FASTA FT scores: opt: 774, E(): 1.3e-36, (41.0% identity in 495 aa FT overlap); Q9K9Z6|BH2498 HYPOTHETICAL PROTEIN from Bacillus FT halodurans (557 aa), FASTA scores: opt: 268, E(): 8e-08, FT (27.7% identity in 502 aa overlap) (N-terminus longer 76 FT aa); Q9X293 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga FT maritima (497 aa), FASTA scores: opt: 265, E(): 1.1e-07, FT (24.9% identity in 470 aa overlap) (N-terminus longer 43 FT aa); etc. Also some similarity with P47609|Y369_MYCGE|MG369 FT HYPOTHETICAL PROTEIN from Mycoplasma genitalium (557 aa), FT FASTA scores: opt: 154, E(): 0.25, (20.25% identity in 489 FT aa overlap); this, and following ORF, are similar to FT Y369_MYCGE but no cosmid sequence error was identified." FT /db_xref="GOA:P95121" FT /db_xref="InterPro:IPR019986" FT /db_xref="UniProtKB/TrEMBL:P95121" FT /protein_id="CAB05443.1" FT /translation="MNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAA FT LWRGVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAHEGLAGAVTAAGDAAVIALEKTP FT EQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEPSPRALPTDTATQRPAPQ FT FEVMYLLAVCDAAAADQLRDRLKELGESVAIAAAPPDSYSVHVHTDDAGAAVEAGLAVG FT RVSRIVISALGSGTSGLPAGGWTRGRAVLAVVDGDGAAELFAGEGACVLRPGPDAVTPA FT ADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCTAAIGWGVDVVPVPTGSMVQGL FT AALAVHDAARQAVDDGYSMARAAGASRHGSVRIATQKALTWAGTCKPGDGLGIAGDEVL FT IVADDVAAAAIGLVDLLLASGGDLVTVLIGAGVTEDVAVVLERHVHDHHPGTELVSYRT FT GHRGDALLIGVE" FT CDS complement(212321..212575) FT /transl_table=11 FT /locus_tag="Rv2975c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2975c, (MTCY349.12), len: 84 aa. Conserved FT hypothetical protein, similar to N-terminus of others e.g. FT Q9ZBR4|SC7A1.09 HYPOTHETICAL 59.5 KDA PROTEIN from FT Streptomyces coelicolor (589 aa), FASTA scores: opt: 141, FT E(): 0.0019, (41.25% identity in 80 aa overlap); FT Q98R49|MYPU_1610 HYPOTHETICAL PROTEIN from Mycoplasma FT pulmonis (545 aa), FASTA scores: opt: 127, E(): 0.023, FT (48.0% identity in 50 aa overlap); Q9K9Z6|BH2498 FT HYPOTHETICAL PROTEIN from Bacillus halodurans (557 aa), FT FASTA scores: opt: 126, E(): 0.028, (34.55% identity in 81 FT aa overlap); etc. Also some similarity with N-terminus of FT P47609|Y369_MYCGE|MG369 HYPOTHETICAL PROTEIN from FT Mycoplasma genitalium (557 aa), FASTA scores: opt: 108, FT E(): 0.7, (36.75% identity in 49 aa overlap); this, and FT preceding ORF, are similar to Y369_MYCGE and YLOV PROTEIN FT but no cosmid sequence error was identified." FT /db_xref="GOA:P95120" FT /db_xref="InterPro:IPR001969" FT /db_xref="UniProtKB/TrEMBL:P95120" FT /protein_id="CAB05437.1" FT /translation="MGTADRPLDASALRDWAHAVVSDLILHIDEINRLNVFPVADSDTG FT VNMLFTMRAAVVEADLHANSQADAEDVARVAAALAAGAR" FT CDS complement(213034..213717) FT /transl_table=11 FT /gene="ung" FT /locus_tag="Rv2976c" FT /product="PROBABLE URACIL-DNA GLYCOSYLASE UNG (UDG)" FT /function="INVOLVED IN BASE EXCISION REPAIR.EXCISES URACIL FT RESIDUES FROM THE DNA WHICH CAN ARISE AS A RESULT OF FT MISINCORPORATION OF DUMP RESIDUES BY DNA POLYMERASE OR DUE FT TO DEAMINATION OF CYTOSINE." FT /EC_number="3.2.2.-" FT /note="Rv2976c, (MTCY349.11), len: 227 aa. Probable ung, FT uracil-DNA glycosylase (EC 3.2.2.-) (see citation below), FT equivalent to Q9CBS3 URACIL-DNA GLYCOSYLASE from FT Mycobacterium leprae (227 aa), FASTA scores: opt: 1394, FT E(): 8.8e-85, (88.1% identity in 227 aa overlap). Also FT highly similar to others e.g. Q9EX12 from Streptomyces FT coelicolor (225 aa), FASTA scores: opt: 1134, E(): 1.3e-67, FT (72.75% identity in 224 aa overlap); Q9K682|UNG_BACHD from FT Bacillus halodurans (224 aa), FASTA scores: opt: 652, E(): FT 8.9e-36, (45.5% identity in 222 aa overlap); FT P39615|UNG_BACSU from Bacillus subtilis (225 aa), FASTA FT scores: opt: 625, E(): 5.4e-34, (45.5% identity in 222 aa FT overlap); etc. BELONGS TO THE URACIL-DNA GLYCOSYLASE FT FAMILY." FT /db_xref="GOA:P67071" FT /db_xref="InterPro:IPR005122" FT /db_xref="PDB:2ZHX" FT /db_xref="UniProtKB/Swiss-Prot:P67071" FT /protein_id="CAB05436.1" FT /translation="MTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPA FT GSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSLANIFDEYTAD FT LGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAPL FT VAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPI FT DWRLP" FT CDS complement(213750..214751) FT /transl_table=11 FT /gene="thiL" FT /locus_tag="Rv2977c" FT /product="PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL FT (THIAMINE-PHOSPHATE KINASE)" FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY: ATP + THIAMINE PHOSPHATE = ADP + THIAMINE FT DIPHOSPHATE]." FT /EC_number="2.7.4.16" FT /note="Rv2977c, (MTCY349.10), len: 333 aa. Possible thiL, FT thiamin-monophosphate kinase (EC ), equivalent to Q9CBS2 FT PROBABLE THIAMINE-MONOPHOSPHATE KINASE from Mycobacterium FT leprae (325 aa), FASTA scores: opt: 1738, E(): 4.5e-98, FT (80.9% identity in 314 aa overlap). Also highly similar to FT others e.g. Q9ZBR7|SC7A1.06 PUTATIVE THIAMINE MONPHOSPHATE FT KINASE from Streptomyces coelicolor (322 aa), FASTA scores: FT opt: 959, E(): 7.8e-51, (51.1% identity in 319 aa overlap); FT O05514|THIL_BACSU THIAMINE-MONOPHOSPHATE KINASE from FT Bacillus subtilis (325 aa), FASTA scores: opt: 476, E(): FT 1.5e-21, (35.15% identity in 273 aa overlap); FT P77785|THIL_ECOLI|THIL|B0417 THIAMINE-MONOPHOSPHATE KINASE FT from Escherichia coli strain K12 (325 aa), FASTA scores: FT opt: 418, E(): 5e-18, (36.9% identity in 282 aa overlap); FT etc. BELONGS TO THE THIAMINE-MONOPHOSPHATE KINASE FAMILY. FT Note that the start, as given, is in IS1538." FT /db_xref="GOA:P95118" FT /db_xref="InterPro:IPR010918" FT /db_xref="UniProtKB/TrEMBL:P95118" FT /protein_id="CAB05435.1" FT /translation="MTTKDHSLATESPTLQQLGEFAVIDRLVRGRRQPATVLLGPGDDA FT ALVSAGDGRTVVSTDMLVQDSHFRLDWSTPQDVGRKAIAQNAADIEAMGARATAFVVGF FT GAPAETPAAQASALVDGMWEEAGRIGAGIVGGDLVSCRQWVVSVTAIGDLDGRAPVLRS FT GAKAGSVLAVVGELGRSAAGYALWCNGIEDFAELRRRHLVPQPPYGHGAAAAAVGAQAM FT IDVSDGLLADLRHIAEASGVRIDLSAAALAADRDALTAAATALGTDPWPWVLSGGEDHA FT LVACFVGPVPAGWRTIGRVLDGPARVLVDGEEWTGYAGWQSFGEPDNQGSLG" FT repeat_region 214731..214736 FT /note="6 bp inverted repeat at the left end of IS1538, FT TGAGTG" FT repeat_region complement(214731..216755) FT /mobile_element="insertion sequence:IS1538" FT /note="IS1538, len: 2025 bp. Similar to other Insertion FT sequence elements in M. tuberculosis e.g. IS1535, IS1536, FT IS1537, & IS1539 (EM_NEW:MTCY274 Z74024 Mycobacterium FT tuberculosis cosmid Y274)" FT CDS complement(214748..216127) FT /transl_table=11 FT /locus_tag="Rv2978c" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1538." FT /note="Rv2978c, (MTCY349.09), len: 459 aa. Probable FT transposase for IS1538, very similar to several other FT putative transposases from Mycobacterium tuberculosis e.g. FT YX16_MYCTU|Q10809 (460 aa), FASTA scores: opt: 2613, E(): FT 0, (83.0% identity in 458 aa overlap); etc. Low level FT matches to other tranposases." FT /db_xref="InterPro:IPR010095" FT /db_xref="UniProtKB/TrEMBL:P95117" FT /protein_id="CAB05434.1" FT /translation="MPKFEVPDGWTVQAFRFTLDPTEDQAKALARHFGARRKAYNWTVA FT TLKADIQAWHASGTVTAKPSLRVLRKRWNTVKDDVCVNTETGVAWWPECSKEAYADGIA FT GAVEAYWNWQTSRAGKRAGKRVGFPRFKRKGRDQDRVSFTTGAMRVEPDRRHLTLPVIG FT TVRTHENTRRIERLIKAGRARVLAISVRRNGTRLDASVRVLVQRPQQPKVVHPGSRVGV FT DVGVRRLATVATADGTAIEQVENPRPLGAALRELRHVCRARSRCTKGSRRYRERTTQIS FT RLHRRVNDVRTHHLHVLTTRLAQTHGRIVVEGLDATEMLRQKGLPGARARRRGLSDAAL FT GTPRRHLSYKTVWYGSALVVADRWFPSSKTCHACRHVQDIGWDEQWQCDRCSVVHQRDD FT CAAINLARYEETSSIVGPVGAAVKRGADRKTGPRPAGGCEARKGSSPKAAEQPRDGVQV FT A" FT CDS complement(216127..216711) FT /transl_table=11 FT /locus_tag="Rv2979c" FT /product="PROBABLE RESOLVASE" FT /function="PREVENTS THE COINTEGRATION OF FOREIGN DNA BEFORE FT INTEGRATION INTO THE CHROMOSOME." FT /note="Rv2979c, (MTCY349.08), len: 194 aa. Probable FT resolvase for IS1538, with low level matches to transposon FT resolvases; highly similar from aa 101 to YX1C_MYCTU|Q10831 FT from Mycobacterium tuberculosis (295 aa), FASTA scores: FT opt: 809, E(): 0, (69.1% identity in 194 aa overlap). FT Contains PS00397 Site-specific recombinases active site, FT and possible helix-turn-helix motiv at aa 2-23." FT /db_xref="GOA:P95116" FT /db_xref="InterPro:IPR006119" FT /db_xref="UniProtKB/TrEMBL:P95116" FT /protein_id="CAB05433.1" FT /translation="MNLATWAERNGVAPGTAYRWFRAGLLSVMARRVGRLILVDEPAGD FT AGMRSPTAVYARVSSADQKADLDRQVARVTAWATAQQMPVDKVVTEVGSAFNEHRRKFL FT SLLRDPSVHRIVVEHRDRFCRLGSKYVQAAFAAQGRELVVVDSAEVDDDLVRDMTEILT FT SMCARLYGKRAAENRTKRALAAAAGEDHEAA" FT misc_feature complement(216523..216549) FT /note="PS00397 Site-specific recombinases active site" FT repeat_region complement(216750..216755) FT /note="6 bp inverted repeat at the right end of IS1538, FT TGAGTG." FT CDS 216923..217468 FT /transl_table=11 FT /locus_tag="Rv2980" FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv2980, (MTCY349.07c), len: 181 aa. Possible FT conserved secreted protein, equivalent to Q9CBS1 POSSIBLE FT SECRETED PROTEIN from Mycobacterium leprae (191 aa), FASTA FT scores: opt: 794, E(): 2.3e-40, (67.25% identity in 177 aa FT overlap). Also some weak similarity with other hypothetical FT proteins or secreted proteins e.g. C-terminus of FT Q98F98|MLL3872 MLL3872 PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (575 aa), FASTA scores: opt: 148, E(): FT 0.16, (28.35% identity in 194 aa overlap); FT Q9L0W9|SCH22A.13C PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (167 aa), FASTA scores: opt: 114, FT E(): 7.5, (40.0% identity in 80 aa overlap); etc. FT Equivalent to AAK47385 from Mycobacterium tuberculosis FT strain CDC1551 (214 aa) but shorter 33 aa. Has hydrophobic FT stretch near N-terminus." FT /db_xref="UniProtKB/TrEMBL:P95115" FT /protein_id="CAB05432.1" FT /translation="MTGESDGPPRAVLIAAAALAAAVIGVILVVAANRQPPERPVVIPA FT VPAPQATGPGCKALLAALPQRLGEYRRAPVAEPTTAGATAWRTGPNSTPVILRCGLDRP FT AEFVVGSAIQVVDRVQWFQVAAQNPDEPGRSTWYTVDRPVYVALTLPSGSGPTAIQELS FT DVIDHTIPAVPIDPAPAR" FT CDS complement(217759..218880) FT /transl_table=11 FT /gene="ddlA" FT /locus_tag="Rv2981c" FT /standard_name="ddl" FT /product="PROBABLE D-ALANINE--D-ALANINE LIGASE DDLA FT (D-ALANYLALANINE SYNTHETASE) (D-ALA-D-ALA LIGASE)" FT /function="INVOLVED IN CELL WALL FORMATION. ALONG WITH FT ALANINE RACEMASE, IT MAKES UP THE D-ALANINE BRANCH OF THE FT PEPTIDOGLYCAN BIOSYNTHETIC ROUTE. [CATALYTIC ACTIVITY: ATP FT + D-ALANINE + D-ALANINE = ADP + PHOSPHATE + FT D-ALANYL-D-ALANINE]." FT /EC_number="6.3.2.4" FT /note="Rv2981c, (MTCY349.06), len: 373 aa. Probable ddlA FT (alternate gene name: ddl), D-alanine--D-alanine ligase A FT (EC 6.3.2.4) (see citation below), equivalent to FT Q9CBS0|Q9CBS0 D-ALANINE-D-ALANINE LIGASE A from FT Mycobacterium leprae (384 aa), FASTA scores: opt: 2001, FT E(): 2.4e-115, (81.75% identity in 367 aa overlap); and FT Q9ZGN0|DDL_MYCSM D-ALANINE--D-ALANINE LIGASE from FT Mycobacterium smegmatis (373 aa), FASTA scores: opt: 1934, FT E(): 3.1e-111, (77.95% identity in 372 aa overlap). Also FT highly similar to others e.g. Q9ZBR9|DDL_STRCO from FT Streptomyces coelicolor (389 aa), FASTA scores: opt: 1187, FT E(): 2.2e-65, (52.0% identity in 379 aa overlap); FT P15051|DDLA_SALTY from Salmonella typhimurium and FT Salmonella typhi (363 aa), FASTA scores: opt: 946, E(): FT 1.3e-50, (44.5% identity in 364 aa overlap); FT P23844|DDLA_ECOLI|DDLA|B0381|Z0477|ECS0431 from Escherichia FT coli strain O157:H7 and K12 (364 aa), FASTA scores: opt: FT 938, E(): 3.9e-50, (43.55% identity in 363 aa overlap); FT etc. Contains PS00843 D-alanine--D-alanine ligase signature FT 1. BELONGS TO THE D-ALANINE--D-ALANINE LIGASE FAMILY." FT /db_xref="GOA:P95114" FT /db_xref="HSSP:1E4E" FT /db_xref="InterPro:IPR013816" FT /db_xref="UniProtKB/Swiss-Prot:P95114" FT /protein_id="CAB05431.1" FT /translation="MSANDRRDRRVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFDV FT IAVGITPAGSWVLTDANPDALTITNRELPQVKSGSGTELALPADPRRGGQLVSLPPGAG FT EVLESVDVVFPVLHGPYGEDGTIQGLLELAGVPYVGAGVLASAVGMDKEFTKKLLAADG FT LPVGAYAVLRPPRSTLHRQECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARR FT HDPKVIVEAAISGRELECGVLEMPDGTLEASTLGEIRVAGVRGREDSFYDFATKYLDDA FT AELDVPAKVDDQVAEAIRQLAIRAFAAIDCRGLARVDFFLTDDGPVINEINTMPGFTTI FT SMYPRMWAASGVDYPTLLATMIETTLARGVGLH" FT misc_feature complement(218494..218529) FT /note="PS00843 D-alanine--D-alanine ligase signature 1" FT CDS complement(218958..219962) FT /transl_table=11 FT /gene="gpdA2" FT /locus_tag="Rv2982c" FT /standard_name="gpsA" FT /product="PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE FT [NAD(P)+] GPDA2 (NAD(P)H-DEPENDENT GLYCEROL-3-PHOSPHATE FT DEHYDROGENASE)" FT /function="INVOLVED IN DE NOVO PHOSPHOLIPID BIOSYNTHESIS; FT GLYCEROL-3 PHOSPHATE FORMATION [CATALYTIC ACTIVITY: FT SN-GLYCEROL 3-PHOSPHATE + NAD(P)(+) = GLYCERONE PHOSPHATE + FT NAD(P)H]." FT /EC_number="1.1.1.94" FT /note="Rv2982c, (MTCY349.05), len: 334 aa. Probable gpdA2 FT (alternate gene name: gpsA), glycerol-3-phosphate FT dehydrogenase [NAD(P)+] (EC 1.1.1.94), equivalent to FT Q9CBR9|GPDA_MYCLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE FT [NAD(P)+] from Mycobacterium leprae (349 aa), FASTA scores: FT opt: 1686, E(): 1.7e-95, (77.95% identity in 349 aa FT overlap). Also highly similar to others e.g. FT Q9ZBS0|GPDA_STRCO from Streptomyces coelicolor (336 aa), FT FASTA scores: opt: 1165, E(): 9.8e-64, (56.25% identity in FT 327 aa overlap); P46919|GPDA_BACSU from Bacillus subtilis FT (345 aa), FASTA scores: opt: 872, E(): 7.5e-46, (44.9% FT identity in 325 aa overlap); FT P37606|GPDA_ECOLI|GPSA|B3608|Z5035|ECS4486. from FT Escherichia coli strain O157:H7 and K12 (339 aa), FASTA FT scores: opt: 799, E(): 2.1e-41, (42.9% identity in 331 aa FT overlap); etc. Also highly similar to O53761|GPD2_MYCTU FT PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE from FT Mycobacterium tuberculosis (341 aa), FASTA scores: opt: FT 740, E(): 8.4e-38, (40.35% identity in 322 aa overlap). FT BELONGS TO THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE FT DEHYDROGENASE FAMILY." FT /db_xref="GOA:P95113" FT /db_xref="HSSP:1EVY" FT /db_xref="InterPro:IPR006109" FT /db_xref="UniProtKB/Swiss-Prot:P95113" FT /protein_id="CAB05430.1" FT /translation="MAGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQIN FT TTRYNPDYLPGALLPPSIHATADAEEALGGASTVLLGVPAQTMRANLERWAPLLPEGAT FT LVSLAKGIELGTLMRMSQVIISVTGAEPPQVAVISGPNLASEIAECQPAATVVACSDSG FT RAVALQRALNSGYFRPYTNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAIITRG FT LAEIIRLGTALGANGATLAGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAGKACH FT VVEGVTSCESVLALASSYDVEMPLTDAVHRVCHKGLSVDEAITLLLGRRTKPE" FT CDS 220081..220725 FT /transl_table=11 FT /locus_tag="Rv2983" FT /product="CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2983, (MTCY349.04c), len: 214 aa. Conserved FT hypothetical ala-rich protein, equivalent to FT O33128|ML1680|MLCB637.37c HYPOTHETICAL 22.0 KDA PROTEIN FT from Mycobacterium leprae (216 aa), FASTA scores: opt: FT 1080, E(): 9e-61, (79.05% identity in 215 aa overlap). Also FT similar to other hypothetical proteins e.g. FT Q9ZBS2|SC7A1.01C from Streptomyces coelicolor (212 aa), FT FASTA scores: opt: 420, E(): 2.9e-19, (43.5% identity in FT 207 aa overlap); O26710|MTH613 from Methanothermobacter FT thermautotrophicus (223 aa), FASTA scores: opt: 193, E(): FT 5.8e-05, (30.0% identity in 190 aa overlap); FT Q9RKG8|SCE46.21 from Streptomyces coelicolor (210 aa), FT FASTA scores: opt: 139, E(): 0.14, (27.65% identity in 206 FT aa overlap); etc." FT /db_xref="InterPro:IPR002835" FT /db_xref="UniProtKB/TrEMBL:P95112" FT /protein_id="CAB05429.1" FT /translation="MSGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVD FT TLTAAAGVGSLRSITVITPDEAAAAAAAGLGADVLADPTPEDDPDPLNTAITAAERVVA FT EGASNIVVLQGDLPALQTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHPRFG FT PDSSARHRRSGAVELTGAWPGLRCDVDTPADLTAARQLGVGPATARAVAHR" FT CDS 220817..223045 FT /transl_table=11 FT /gene="ppk" FT /locus_tag="Rv2984" FT /product="PROBABLE POLYPHOSPHATE KINASE PPK (POLYPHOSPHORIC FT ACID KINASE) (ATP-POLYPHOSPHATE PHOSPHOTRANSFERASE)" FT /function="CATALYZES THE REVERSIBLE TRANSFER OF THE FT TERMINAL PHOSPHATE OF ATP TO FORM A LONG-CHAIN FT POLYPHOSPHATE (POLYP) [CATALYTIC ACTIVITY: ATP + FT {PHOSPHATE}(N) = ADP + {PHOSPHATE}(N+1)]." FT /EC_number="2.7.4.1" FT /note="Rv2984, (MTCY349.03c), len: 742 aa. Probable ppk, FT polyphosphate kinase (EC 2.7.4.1), equivalent to FT O33127|PPK_MYCLE POLYPHOSPHATE KINASE from Mycobacterium FT leprae (739 aa), FASTA scores: opt: 4264, E(): 0, (87.85% FT identity in 742 aa overlap). Also highly similar to others FT e.g. Q9KZV6|PPK_STRCO from Streptomyces coelicolor (746 FT aa), FASTA scores: opt: 1979, E(): 2.6e-117, (59.9% FT identity in 701 aa overlap); Q9KD27|PPK_BACHD from Bacillus FT halodurans (705 aa), FASTA scores: opt: 1319, E(): 1.4e-75, FT (45.55% identity in 674 aa overlap); Q9PAC7|PPK_XYLFA from FT Xylella fastidiosa (698 aa), FASTA scores: opt: 1300, E(): FT 2.2e-74, (43.3% identity in 693 aa overlap); etc. BELONGS FT TO THE POLYPHOSPHATE KINASE FAMILY." FT /db_xref="GOA:P65768" FT /db_xref="InterPro:IPR003414" FT /db_xref="UniProtKB/Swiss-Prot:P65768" FT /protein_id="CAB05444.1" FT /translation="MMSNDRKVTEIENSPVTEVRPEEHAWYPDDSALAAPPAATPAAIS FT DQLPSDRYLNRELSWLDFNARVLALAADKSMPLLERAKFLAIFASNLDEFYMVRVAGLK FT RRDEMGLSVRSADGLTPREQLGRIGEQTQQLASRHARVFLDSVLPALGEEGIYIVTWAD FT LDQAERDRLSTYFNEQVFPVLTPLAVDPAHPFPFVSGLSLNLAVTVRQPEDGTQHFARV FT KVPDNVDRFVELAAREASEEAAGTEGRTALRFLPMEELIAAFLPVLFPGMEIVEHHAFR FT ITRNADFEVEEDRDEDLLQALERELARRRFGSPVRLEIADDMTESMLELLLRELDVHPG FT DVIEVPGLLDLSSLWQIYAVDRPTLKDRTFVPATHPAFAERETPKSIFATLREGDVLVH FT HPYDSFSTSVQRFIEQAAADPNVLAIKQTLYRTSGDSPIVRALIDAAEAGKQVVALVEI FT KARFDEQANIAWARALEQAGVHVAYGLVGLKTHCKTALVVRREGPTIRRYCHVGTGNYN FT SKTARLYEDVGLLTAAPDIGADLTDLFNSLTGYSRKLSYRNLLVAPHGIRAGIIDRVER FT EVAAHRAEGAHNGKGRIRLKMNALVDEQVIDALYRASRAGVRIEVVVRGICALRPGAQG FT ISENIIVRSILGRFLEHSRILHFRAIDEFWIGSADMMHRNLDRRVEVMAQVKNPRLTAQ FT LDELFESALDPCTRCWELGPDGQWTASPQEGHSVRDHQESLMERHRSP" FT CDS 223128..224081 FT /transl_table=11 FT /gene="mutT1" FT /locus_tag="Rv2985" FT /product="POSSIBLE HYDROLASE MUTT1" FT /function="UNKNOWN; HYDROLYTIC ENZYME. POSSIBLY INVOLVED IN FT REMOVAL OF DAMAGED NUCLEOTIDE." FT /EC_number="3.-.-.-" FT /note="Rv2985, (MTCY349.02c), len: 317 aa. Possible mutT1, FT long MutT protein (hydrolase) (EC 3.-.-.-) (see citation FT below), highly similar to O33126|MLCB637.35 HYPOTHETICAL FT 34.5 KDA PROTEIN from Mycobacterium leprae (312 aa), FASTA FT scores: opt: 1514, E(): 5.1e-91, (71.85% identity in 316 aa FT overlap); and Q9CBR8|ML1682 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (311 aa), FASTA scores: opt: 1510, FT E(): 9.2e-91, (71.5% identity in 316 aa overlap). Also FT similar to Q50195|L222-ORF6|ML2698 HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (251 aa), FASTA scores: opt: 231, FT E(): 1.1e-07, (36.7% identity in 128 aa overlap). Also FT similar to shorter mutt proteins and related hypothetical FT protein e.g. Q9EUS6 HYPOTHETICAL 16.6 KDA PROTEIN from FT Streptomyces griseus subsp. griseus (152 aa), FASTA scores: FT opt: 380, E(): 1.7e-17, (50.75% identity in 130 aa FT overlap); Q9KZV8|SCD84.10C PUTATIVE MUTT-LIKE PROTEIN from FT Streptomyces coelicolor (142 aa), FASTA scores: opt: 376, FT E(): 2.9e-17, (46.1% identity in 128 aa overlap); FT P96590|MUTT MUTT PROTEIN from Bacillus subtilis (149 aa), FT FASTA scores: opt: 180, E(): 0.00017, (35.25% identity in FT 122 aa overlap); etc. Also similar to O05437 HYPOTHETICAL FT 27.1 KDA PROTEIN from Mycobacterium tuberculosis (248 aa), FT FASTA scores: opt: 224, E(): 3.2e-07, (34.03% identity in FT 144 aa overlap). Contains PS00893 mutT domain signature. FT SEEMS TO BELONG TO THE MUTT/NUDIX FAMILY PROTEIN." FT /db_xref="GOA:P95110" FT /db_xref="HSSP:1KTG" FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/TrEMBL:P95110" FT /protein_id="CAB05428.1" FT /translation="MSIQNSSARRRSAGRIVYAAGAVLWRPGSADSEGPVEIAVIHRPR FT YDDWSLPKGKVDPGETAPVGAVREILEETGHRANLGRRLLTVTYPTDSPFRGVKKVHYW FT AARSTGGEFTPGSEVDELIWLPVPDAMNKLDYAQDRKVLCRFAKHPADTQTVLVVRHGT FT AGSKAHFSGDDSKRPLDKRGRAQAEALVPQLLAFGATDVYAADRVRCHQTMEPLAAELN FT VTIHNEPTLTEESYANNPKRGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCERDGVHP FT DKSRNRKGSTWVLSLSAGRLVTADHIGGALAANVRA" FT misc_feature 223287..223346 FT /note="PS00893 mutT domain signature" FT CDS complement(224139..224783) FT /transl_table=11 FT /gene="hupB" FT /locus_tag="Rv2986c" FT /standard_name="hup; hlp; lbp21" FT /product="PROBABLE DNA-BINDING PROTEIN HU HOMOLOG HUPB FT (HISTONE-LIKE PROTEIN) (HLP) (21-KDA LAMININ-2-BINDING FT PROTEIN)" FT /function="THIS PROTEIN BELONGS TO THE HISTONE LIKE FAMILY FT OF PROKARYOTIC DNA-BINDING PROTEINS WHICH ARE CAPABLE OF FT WRAPPING DNA TO STABILIZE IT, AND PREVENT ITS DENATURATION FT UNDER EXTREME ENVIRONMENTAL CONDITIONS." FT /note="Rv2986c, (MTCY349.01), len: 214 aa. Probable hupB FT (alternate gene names: hup, hlp, lbp21), DNA-binding FT protein HU homolog (resembles fusion between HU and FT histone) (see Pethe et al., 2002), equivalent to others FT from Mycobacteria e.g. Q9XB18|DBH_MYCBO from Mycobacterium FT bovis (205 aa), FASTA scores: opt: 1050, E(): 5.6e-45, FT (95.35% identity in 214 aa overlap); Q9ZHC5|DBH_MYCSM from FT Mycobacterium smegmatis (208 aa), FASTA scores: opt: 1035, FT E(): 3.1e-44, (80.2% identity in 217 aa overlap); and FT O33125|DBH_MYCLE from Mycobacterium leprae (200 aa), FASTA FT scores: opt: 914, E(): 2.7e-38, (80.1% identity in 216 aa FT overlap). Also highly similar to others from other FT organisms e.g. O86537|DBH2_ST |