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EBI DbfetchID BX842580; SV 1; linear; genomic DNA; STD; PRO; 346051 BP. XX AC BX842580; AL008687; AL008967; AL021185-AL021186; AL021246; Z77250; Z77724; AC Z80225; Z83863; Z95387; Z95556; Z96072; Z97051; Z98045; Z98209; XX DT 21-NOV-2003 (Rel. 77, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 9/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-346051 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF00005; tRNA. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..346051 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT CDS 142..528 FT /transl_table=11 FT /gene="glbO" FT /locus_tag="Rv2470" FT /product="POSSIBLE GLOBIN (OXYGEN-BINDING PROTEIN) GLBO" FT /function="OXYGEN CARRIER, INVOLVED IN OXYGEN TRANSPORT." FT /note="Rv2470, (MTV008.26), len: 128 aa. Possible glbO, FT globin-like protein, highly similar to Q9CC59|GLBO|ML1253 FT HEMOGLOBIN-LIKE (OXYGEN CARRIER) from Mycobacterium leprae FT (128 aa), FASTA scores: opt: 767, E(): 4e-47, (88.1% FT identity in 126 aa overlap); Q9X7B3|MLCB1610.14c PUTATIVE FT GLOBIN from Mycobacterium leprae (131 aa); Q9L250|SC6D10.14 FT PUTATIVE GLOBIN from Streptomyces coelicolor (137 aa), FT FASTA scores: opt: 466, E(): 5.7e-26, (53.6% identity in FT 125 aa overlap). Also similar to O31607 YJBI PROTEIN from FT Bacillus subtilis (132 aa), FASTA scores: opt: 294, E(): FT 6.6e-14; (39.85% identity in 128 aa overlap). COULD BELONG FT TO PROTOZOAN/CYANOBACTERIAL GLOBIN FAMILY PROTEIN." FT /db_xref="GOA:P0A595" FT /db_xref="InterPro:IPR001486" FT /db_xref="PDB:1NGK" FT /db_xref="UniProtKB/Swiss-Prot:P0A595" FT /protein_id="CAA16047.1" FT /translation="MPKSFYDAVGGAKTFDAIVSRFYAQVAEDEVLRRVYPEDDLAGAE FT ERLRMFLEQYWGGPRTYSEQRGHPRLRMRHAPFRISLIERDAWLRCMHTAVASIDSETL FT DDEHRRELLDYLEMAAHSLVNSPF" FT CDS 528..2168 FT /transl_table=11 FT /gene="aglA" FT /locus_tag="Rv2471" FT /product="PROBABLE ALPHA-GLUCOSIDASE AGLA (MALTASE) FT (GLUCOINVERTASE) (GLUCOSIDOSUCRASE) (MALTASE-GLUCOAMYLASE) FT (LYSOSOMAL ALPHA-GLUCOSIDASE) (ACID MALTASE)" FT /function="INVOLVED IN SUGAR METABOLISM (HYDROLYSIS OF FT TERMINAL, NON-REDUCING 1,4-LINKED D-GLUCOSE RESIDUES WITH FT RELEASE OF D-GLUCOSE)." FT /EC_number="3.2.1.20" FT /note="Rv2471, (MTV008.27), len: 546 aa. Probable aglA, FT maltase (alpha-glucosidase) (EC 3.2.1.20), highly similar FT or similar to several e.g. Q60027|AGLA from Thermomonospora FT curvata (544 aa), FASTA scores: opt: 2071, E(): 4e-116, FT (57.7% identity in 525 aa overlap); Q9KZE3|AGLAE from FT Streptomyces coelicolor (534 aa), FASTA scores: opt: 1475, FT E(): 1.5e-80, (50.1% identity in 537 aa overlap); FT O86874|AGLA from Streptomyces lividans (534 aa), FASTA FT scores: opt: 1473, E(): 2e-80, (50.1% identity in 537 aa FT overlap); etc. SEEMS TO BELONG TO FAMILY 13 OF GLYCOSYL FT HYDROLASES, ALSO KNOWN AS THE ALPHA-AMYLASE FAMILY." FT /db_xref="GOA:O53198" FT /db_xref="HSSP:1M53" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/TrEMBL:O53198" FT /protein_id="CAA16048.1" FT /translation="MDQHQRPDPMGPGSPRASARRPEPDPMGEPWWSRAVFYQVYPRSF FT ADSNGDGVGDLDGLASRLDHLQQLGVDAIWINPVTVSPMADHGYDVADPRDIDPLFGGM FT PAFERLVAAAHRQGIKVTMDVVPNHTSSAHPWFQAALADLPGSPARDRYFFRDGRGPDG FT SLPPNNWESVFGGPAWTRVREPDGNPGQWYLHLFDTEQPDLNWDNPEILDDFEKTLRFW FT LDRGVDGFRIDVAHGMAKPPGLPDSPDLGIEVLHHRDDDPRFNHPNVHAIHRDIRTVID FT EYPGAVTVGEVWVHDNARWAEYLRPDELHLGFNFRLARTEFDAAEIRDAVANSLAAAAL FT QNATPTWTLANHDVGREVSRYGGGEIGLRRAKAMAVVMLALPGVVFLYNGQELGLPDVD FT LPDEVLQDPTWERSGRTERGRDGCRVPIPWSGNIPPFGFSTCPDTWLPMPPEWAALTAE FT KQRADAGSTLSFFRLALRLRRERNEFDGDVDWLAAPDDALIFRRHGGGLVCALNAAERP FT LALPAGEPILASAPLTDATLPPNAAAWLV" FT CDS 2236..2529 FT /transl_table=11 FT /locus_tag="Rv2472" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2472, (MTV008.28), len: 97 aa. Conserved FT hypothetical protein, showing some similarity to FT O53451|Rv1103c|MTV017.56c from Mycobacterium tuberculosis FT strain H37Rv (106 aa), FASTA scores: opt: 135, E(): 0.026, FT (45.85% identity in 72 aa overlap); and AAK45393|MT1135 FT HYPOTHETICAL 11.4 KDA PROTEIN from Mycobacterium FT tuberculosis strain CDC1551 (78 aa) FASTA scores: opt: 139, FT E(): 0.011, (45.35% identity in 75 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O53199" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16049.1" FT /translation="MMMRIAVRLPGEVITFVDSEVSQIRIPSRRAAVVLRASNASDAAI FT LTATEPNHHLDALAGQAAKLAPTSIDAAHPARPARRDPCLYPRTGQALPRTG" FT CDS 2532..3248 FT /transl_table=11 FT /locus_tag="Rv2473" FT /product="POSSIBLE ALANINE AND PROLINE RICH MEMBRANE FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv2473, (MTV008.29), len: 238 aa. Possible FT pro-,ala-rich membrane protein, with possible transmembrane FT domain around aa 81-104." FT /db_xref="UniProtKB/TrEMBL:O53200" FT /protein_id="CAA16050.1" FT /translation="MAPTSSSVASELLMPWPSAAASGVVGWRTTATASQRYHRPMSDTP FT FAEPYPEQRPPWGVPPPGWDGSSRPAPSTTPRSPGRWSLVAALALAVVSLGVGIVGWFH FT RQPHDKPSPAPSAPTFTSQQISDAKENVCAAHRIVRQAAVLNTNQANPVPGDPTGDLAV FT AANARLALYSGGDYLLRRLTAEPATPAELRDAVRSLANALQELAVNYLAGAPDSVVTPL FT RLALERDTRAVDPLCV" FT CDS complement(3280..3933) FT /transl_table=11 FT /locus_tag="Rv2474c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2474c, (MTV008.30c), len: 217 aa. Hypothetical FT protein. Shows weak similarity with Q9L246|SC6D10.18c FT HYPOTHETICAL 24.9 KDA PROTEIN from Streptomyces coelicolor FT (238 aa), FASTA scores: opt: 111, E(): 5.6, (30% identity FT in 233 aa overlap), BLASTP scores: Score= 135, E= 3.5e-07, FT P= 3.5e-07, Identities= 55/182 (30%)." FT /db_xref="InterPro:IPR016601" FT /db_xref="UniProtKB/TrEMBL:O53201" FT /protein_id="CAA16051.1" FT /translation="MVERGLWLPDPAHRADLATFVDHALRLDDAAVIRIRARSTGLLSA FT WVATGFDVLASRVVAGKVRPDDLSVAARSLAHGLATTDASGYVDPGYSMDSAWRGGLPP FT ESGFTYLDDVPARVMLDLAHRGARLAKEHGSSAGPPVSLLDQEVIQVSSADVVVGLPMR FT CVFALTAMGFLPQSAETISADELIRVRISPAWLRLDARFGSVYRHRGHAALVLR" FT CDS complement(3939..4355) FT /transl_table=11 FT /locus_tag="Rv2475c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2475c, (MTV008.31c), len: 138 aa. Conserved FT hypothetical protein, showing similarity with FT Q9L245|SC6D10.19c HYPOTHETICAL 16.2 KDA PROTEIN from FT Streptomyces coelicolor (136 aa), FASTA scores: opt: 236, FT E(): 1.9e-09, (34.1% identity in 126 aa overlap). Also some FT similarity with AAK44393|Z97050|MTCI28_3 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis cosmid FT I (151 aa), FASTA scores: opt: 147, E(): 0.00025, (29.2% FT identity in 120 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O53202" FT /protein_id="CAA16052.1" FT /translation="MSVGFVTPVGVRWSDIDMYQHVNHATMVTILEEARVPFLKDAFGA FT DITSTGLLIADVRVTYKGQLRLSDSPLQVTIWTKRLRAVDFTLGYEVRSVNAEPDSRPA FT VIAESQLAAFHIEEQRLVRLSPHHREYLQRWFRG" FT CDS complement(4352..9226) FT /transl_table=11 FT /gene="gdh" FT /locus_tag="Rv2476c" FT /product="PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE FT GDH (NAD-GDH) (NAD-DEPENDENT GLUTAMIC DEHYDROGENASE)" FT /function="CATABOLIC GLUTDH INVOLVED IN THE UTILIZATION OF FT GLUTAMATE AND OTHER AMINO ACIDS OF THE GLUTAMATE FAMILY. FT GENERATES 2-OXOGLUTARATE FROM L-GLUTAMATE [CATALYTIC FT ACTIVITY: L-GLUTAMATE + H(2)O + NAD(+) = 2-OXOGLUTARATE + FT NH(3) + NADH]." FT /EC_number="1.4.1.2" FT /note="Rv2476c, (MTV008.32c), len: 1624 aa. Probable gdh, FT glutamate dehydrogenase (EC 1.4.1.2). Highly similar to FT Q9X7B2|MLCB1610.10|ML1249 HYPOTHETICAL 177.9 KDA PROTEIN FT from Mycobacterium leprae (1622 aa), FASTA scores: opt: FT 8630,E(): 0, (81.45% identity in 1634 aa overlap). But FT highly similar to Q9F0J1|GDH NAD-GLUTAMATE DEHYDROGENASE FT from Streptomyces clavuligerus (1651 aa), FASTA scores: FT opt: 3833, E(): 0, (45.8% identity in 1600 aa overlap); FT (see Minambres et al., 2000). Also similar with others e.g. FT AAG53963|PA3068|GDHB HYPOTHETICAL (NAD(+)-DEPENDENT FT GLUTAMATE DEHYDROGENASE from Pseudomonas aeruginosa (1620 FT aa), FASTA scores: opt: 2214, E(): 1e-124, (40.1% identity FT in 1561 aa overlap) (see Lu & Abdelal 2001); and FT Q9Y8G5|GDHB NAD-SPECIFIC GLUTAMATE DEHYDROGENASE from FT Agaricus bisporus (1029 aa), FASTA scores: opt: 194, E(): FT 0.00099, (22.7% identity in 647 aa overlap) (see Kersten et FT al., 1999); etc. Contains possible Helix-turn-helix motif FT at aa 1568 to 1589 (score 1098, +2.93 SD)." FT /db_xref="GOA:O53203" FT /db_xref="InterPro:IPR007780" FT /db_xref="UniProtKB/TrEMBL:O53203" FT /protein_id="CAA16053.1" FT /translation="MTIDPGAKQDVEAWTTFTASADIPDWISKAYIDSYRGPRDDSSEA FT TKAAEASWLPASLLTPAMLGAHYRLGRHRAAGESCVAVYRADDPAGFGPALQVVAEHGG FT MLMDSVTVLLHRLGIAYAAILTPVFDVHRSPTGELLRIEPKAEGTSPHLGEAWMHVALS FT PAVDHKGLAEVERLLPKVLADVQRVATDATALIATLSELAGEVESNAGGRFSAPDRQDV FT GELLRWLGDGNFLLLGYQRCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKLLVLAQ FT ARVGSYLRYGAYPYAIAVREYVDGSVVEHRFVGLFSVAAMNADVLEIPTISRRVREALA FT MAESDPSHPGQLLLDVIQTVPRPELFTLSAQRLLTMARAVVDLGSQRQALLFLRADRLQ FT YFVSCLVYMPRDRYTTAVRMQFEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEVG FT VAGEGAAAPPVDVSEANRIRIQGLLTEAARTWADRLIGAAAAAGSVGQADAMHYAAAFS FT EAYKQAVTPADAIGDIAVITELTDDSVKLVFSERDEQGVAQLTWFLGGRTASLSQLLPM FT LQSMGVVVLEERPFSVTRPDGLPVWIYQFKISPHPTIPLAPTVAERAATAHRFAEAVTA FT IWHGRVEIDRFNELVMRAGLTWQQVVLLRAYAKYLRQAGFPYSQSYIESVLNEHPATVR FT SLVDLFEALFVPVPSGSASNRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRT FT NYFVTRQGSARCRDVLALKLNAQLIDELPLPRPRYEIFVYSPRVEGVHLRFGPVARGGL FT RWSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLPTGDPAADRDATRAEG FT VACYQLFISGLLDVTDNVDHATASVNPPPEVVRRDGDDAYLVVAADKGTATFSDIANDV FT AKSYGFWLGDAFASGGSVGYDHKAMGITARGAWEAVKRHFREIGIDTQTQDFTVVGIGD FT MSGDVFGNGMLLSKHIRLIAAFDHRHIFLDPNPDAAVSWAERRRMFELPRSSWSDYDRS FT LISEGGGVYSREQKAIPLSAQVRAVLGIDGSVDGGAAEMAPPNLIRAILRAPVDLLFNG FT GIGTYIKAESESDADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSGGRI FT NTDALDNSAGVDCSDHEVNIKILIDSLVSAGTVKADERTQLLESMTDEVAQLVLADNED FT QNDLMGTSRANAASLLPVHAMQIKYLVAERGVNRELEALPSEKEIARRSEAGIGLTSPE FT LATLMAHVKLGLKEEVLATELPDQDVFASRLPRYFPTALRERFTPEIRSHQLRREIVTT FT MLINDLVDTAGITYAFRIAEDVGVTPIDAVRTYVATDAIFGVGHIWRRIRAANLPIALS FT DRLTLDTRRLIDRAGRWLLNYRPQPLAVGAEINRFAAMVKALTPRMSEWLRGDDKAIVE FT KTAAEFASQGVPEDLAYRVSTGLYRYSLLDIIDIADIADIDAAEVADTYFALMDRLGTD FT GLLTAVSQLPRHDRWHSLARLAIRDDIYGALRSLCFDVLAVGEPGESSEQKIAEWEHLS FT ASRVARARRTLDDIRASGQKDLATLSVAARQIRRMTRTSGRGISG" FT CDS complement(9330..11006) FT /transl_table=11 FT /locus_tag="Rv2477c" FT /product="PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT MACROLIDE ACROSS THE MEMBRANE (EXPORT): MACROLIDE FT ANTIBIOTICS RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE FT FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM." FT /note="Rv2477c, (MTV008.33c), len: 558 aa. Probable ATP FT binding protein ABC-transporter (see citation below), FT probably involved in macrolide transport, equivalent to FT Q9X7B1|MLCB1610.09|ML1248 PUTATIVE ABC TRANSPORTER FT ATP-BINDING PROTEIN from Mycobacterium leprae (556 aa) FT FASTA scores: opt: 3448, E(): 3.8e-176, (92.3% identity in FT 557 aa overlap). Also highly similar to many ATP binding FT proteins e.g. Q9L244|SC6D10.20c PUTATIVE ABC TRANSPORTER FT ATP-BINDING PROTEIN from Streptomyces coelicolor (547 aa), FT FASTA scores: opt: 2937, E(): 5.6e-149, (79.5% identity in FT 551 aa overlap); AAK24119|CC2148 ABC transporter FT ATP-binding protein from Caulobacter crescentus (555 aa), FT FASTA scores: opt: 2175, E(): 1.9e-108, (59.4% identity in FT 557 aa overlap); Q9HVJ1 PROBABLE ATP-BINDING COMPONENT OF FT ABC TRANSPORTER from Pseudomonas aeruginosa (554 aa), FASTA FT scores: opt: 2054, E(): 5.1e-102, (56.9% identity in 559 aa FT overlap); etc. Contains 2 x PS00017 ATP/GTP-binding site FT motif A (P-loop), 2 x PS00211 ABC transporters family FT signature, and probable coiled-coil from aa 273 to 311. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS)." FT /db_xref="GOA:O53204" FT /db_xref="HSSP:1US8" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:O53204" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16054.1" FT /translation="MAEFIYTMKKVRKAHGDKVILDDVTLSFYPGAKIGVVGPNGAGKS FT SVLRIMAGLDKPNNGDAFLATGATVGILQQEPPLNEDKTVRGNVEEGMGDIKIKLDRFN FT EVAELMATDYTDELMEEMGRLQEELDHADAWDLDAQLEQAMDALRCPPADEPVTNLSGG FT ERRRVALCKLLLSKPDLLLLDEPTNHLDAESVQWLEQHLASYPGAILAVTHDRYFLDNV FT AEWILELDRGRAYPYEGNYSTYLEKKAERLAVQGRKDAKLQKRLTEELAWVRSGAKARQ FT AKSKARLQRYEEMAAEAEKTRKLDFEEIQIPVGPRLGNVVVEVDHLDKGYDGRALIKDL FT SFSLPRNGIVGVIGPNGVGKTTLFKTIVGLETPDSGSVKVGETVKLSYVDQARAGIDPR FT KTVWEVVSDGLDYIQVGQTEVPSRAYVSAFGFKGPDQQKPAGVLSGGERNRLNLALTLK FT QGGNLILLDEPTNDLDVETLGSLENALLNFPGCAVVISHDRWFLDRTCTHILAWEGDDD FT NEAKWFWFEGNFGAYEENKVERLGVDAARPHRVTHRKLTRG" FT misc_feature complement(9636..9680) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(9924..9947) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(10485..10529) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(10872..10895) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(11087..11572) FT /transl_table=11 FT /locus_tag="Rv2478c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2478c, (MTV008.34c), len: 161 aa. Conserved FT hypothetical protein, with weak similarity with many FT single-strand binding proteins e.g. Q9X8U3|SCH24.29 FT PUTATIVE SINGLE-STRAND BINDING PROTEIN from Streptomyces FT coelicolor (199 aa), FASTA scores: opt: 246, E(): 4.5e-08, FT (31.5% identity in 162 aa overlap); FT P46390|SSB_MYCLE|ML2684|MLCB1913.20c SINGLE-STRAND BINDING FT PROTEIN (SSB) (HELIX-DESTABILIZING PROTEIN) from FT Mycobacterium leprae (168 aa), FASTA scores: opt: 239, E(): FT 1e-07, (30.8% identity in 146 aa overlap); FT P18310|SSBF_ECOLI SINGLE-STRAND BINDING PROTEIN from FT Escherichia coli (178 aa), FASTA scores: opt: 116, E(): FT 2.9, (25.7% identity in 140 aa overlap); etc. Also FT similarity with Rv0054|P71711|MTCY21D4.17|SSB_MYCTU FT PROBABLE SINGLE-STRAND BINDING PROTEIN from M. tuberculosis FT (164 aa), FASTA scores: opt: 234, E(): 2e-07, (31.75% FT identity in 148 aa overlap). N-terminus shorter 8 aa from FT AAK46855|MT2553 SINGLE-STRAND DNA BINDING PROTEIN from FT Mycobacterium tuberculosis strain CDC1551." FT /db_xref="GOA:O53205" FT /db_xref="HSSP:1UE1" FT /db_xref="InterPro:IPR012340" FT /db_xref="UniProtKB/TrEMBL:O53205" FT /protein_id="CAA16055.1" FT /translation="MVGHIVNDLQRRKVGDQEVVKFRVASNSRRRTSDGGWEPGNSLFI FT TVNCWGRLVTGVGAALGKGAPVIVVGHVYTSEYEDRDGIRRSSLEMRATSVGPDLSRVI FT VRIEKPAYTGPSAGDLPAATGTGAAGAADAPASAADSVSDVVVDDAITGHNPLPISA" FT repeat_region 11578..11606 FT /note="29 bp Inverted repeat at the left end of IS6110, FT GTGAACCGCCCCGGTGAGTCCGGAGACTC" FT repeat_region complement(11578..12934) FT /mobile_element="insertion sequence:IS6110-9" FT /note="IS6110-9, len: 1357 bp. Insertion sequence IS6110." FT CDS complement(11621..>12661) FT /transl_table=11 FT /locus_tag="Rv2479c" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2479c, (MTV008.35c), len: 346 aa. Probable FT transposase for IS6110, identical to many, probably FT translated by frame shifting from the upstream ORF." FT /db_xref="GOA:P0C5G8" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8" FT /protein_id="CAA16056.1" FT /translation="AEALAAGQRRIAKGERDFKDRVGFLRGRARPASTLITRFIADHQG FT HREGPDGLRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAA FT NYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADL FT VQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAI FT EQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAE FT TINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQR FT QRPAAG" FT CDS complement(12556..12882) FT /transl_table=11 FT /locus_tag="Rv2480c" FT /product="POSSIBLE TRANSPOSASE" FT /function="THOUGHT TO BE REQUIRED FOR THE TRANSPOSITION OF FT THE INSERTION ELEMENT IS6110." FT /note="Rv2480c, (MTV008.36c), len: 108 aa. Possible FT transposase for IS6110, identical to many." FT /db_xref="GOA:P0C5G9" FT /db_xref="InterPro:IPR002514" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9" FT /protein_id="CAA16057.1" FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD FT RPAR" FT repeat_region complement(12906..12934) FT /note="29 bp Inverted repeat at the right end of IS6110, FT GTGAACCGCCCCGGCATGTCCGGAGACTC" FT CDS complement(13539..13862) FT /transl_table=11 FT /locus_tag="Rv2481c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2481c, (MTV008.37c), len: 107 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O53206" FT /protein_id="CAA16058.1" FT /translation="MALRRRHEPDGWPFSQRSEKPNAVRHAVRCSAVSAAASTANGTPV FT NWVSGRVTRAMGVHRQTRGGVASVHADSLRGAVLVHGQLRNSIPISANVPASGANTKSS FT IAH" FT CDS complement(13878..16247) FT /transl_table=11 FT /gene="plsB2" FT /locus_tag="Rv2482c" FT /product="PROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE FT PLSB2 (GPAT)" FT /function="INVOLVED IN PHOSPHOLIPID BIOSYNTHESIS (AT THE FT FIRST STEP). MAY ALSO FUNCTION IN THE REGULATION OF FT MEMBRANE BIOGENESIS [CATALYTIC ACTIVITY: ACYL-CoA + FT SN-GLYCEROL 3-PHOSPHATE = CoA + 1-ACYL-SN-GLYCEROL FT 3-PHOSPHATE]." FT /EC_number="2.3.1.15" FT /note="Rv2482c, (MT2555, MTV008.38c), len: 789 aa. Probable FT plsB2, glycerol-3-phosphate acyltransferase (EC 2.3.1.15), FT highly similar to Q9X7B0|PLSB_MYCLE PROBABLE FT GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE from Mycobacterium FT leprae (775 aa), FASTA scores: opt: 4210, E(): 0, (80.7% FT identity in 783 aa overlap). Also similar to others e.g. FT P00482|PLSB_ECOLI from Escherichia coli (806 aa), FASTA FT scores: opt: 521, E(): 3e-24, (24.35 identity in 612 aa FT overlap); Q9CLN7|PLSB_PASMU from Pasteurella multocida (809 FT aa), FASTA scores: opt: 529, E(): 9.7e-25, (27.05% identity FT in 540 aa overlap); Q9KVP8|PLSB_VIBCH from Vibrio cholerae FT (811 aa), FASTA scores: opt: 510, E(): 1.4e-23, (26.0% FT identity in 639 aa overlap); etc. Also highly similar to FT Q10775|PLSB1|Rv1551|MTCY48.14c from M. tuberculosis (621 FT aa), FASTA scores: opt: 1013, E(): 1.5e-54, (34.65% FT identity in 586 aa overlap). BELONGS TO THE GPAT/DAPAT FT FAMILY." FT /db_xref="GOA:O53207" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/Swiss-Prot:O53207" FT /protein_id="CAA16059.1" FT /translation="MTKPAADASAVLTAEDTLVLASTATPVEMELIMGWLGQQRARHPD FT SKFDILKLPPRNAPPAALTALVEQLEPGFASSPQSGEDRSIVPVRVIWLPPADRSRAGK FT VAALLPGRDPYHPSQRQQRRILRTDPRRARVVAGESAKVSELRQQWRDTTVAEHKRDFA FT QFVSRRALLALARAEYRILGPQYKSPRLVKPEMLASARFRAGLDRIPGATVEDAGKMLD FT ELSTGWSQVSVDLVSVLGRLASRGFDPEFDYDEYQVAAMRAALEAHPAVLLFSHRSYID FT GVVVPVAMQDNRLPPVHMFGGINLSFGLMGPLMRRSGMIFIRRNIGNDPLYKYVLKEYV FT GYVVEKRFNLSWSIEGTRSRTGKMLPPKLGLMSYVADAYLDGRSDDILLQGVSICFDQL FT HEITEYAAYARGAEKTPEGLRWLYNFIKAQGERNFGKIYVRFPEAVSMRQYLGAPHGEL FT TQDPAAKRLALQKMSFEVAWRILQATPVTATGLVSALLLTTRGTALTLDQLHHTLQDSL FT DYLERKQSPVSTSALRLRSREGVRAAADALSNGHPVTRVDSGREPVWYIAPDDEHAAAF FT YRNSVIHAFLETSIVELALAHAKHAEGDRVAAFWAQAMRLRDLLKFDFYFADSTAFRAN FT IAQEMAWHQDWEDHLGVGGNEIDAMLYAKRPLMSDAMLRVFFEAYEIVADVLRDAPPDI FT GPEELTELALGLGRQFVAQGRVRSSEPVSTLLFATARQVAVDQELIAPAADLAERRVAF FT RRELRNILRDFDYVEQIARNQFVACEFKARQGRDRI" FT CDS complement(16244..17986) FT /transl_table=11 FT /gene="plsC" FT /locus_tag="Rv2483c" FT /product="POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS FT BIFUNCTIONNAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE FT PHOSPHATASE (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSP) FT (PSPASE) + 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE FT (1-AGP ACYLTRANSFERASE) (1-AGPAT) (LYSOPHOSPHATIDIC ACID FT ACYLTRANSFERASE) (LPAAT)" FT /function="C-TERMINUS: INVOLVED IN PHOSPHOLIPID FT BIOSYNTHESIS (AT THE SECOND STEP); CONVERTS FT LYSOPHOSPHATIDIC ACID (LPA) INTO PHOSPHATIDIC ACID BY FT INCORPORATING ACYL MOIETY AT THE 2 POSITION [CATALYTIC FT ACTIVITY 2: ACYL-CoA + 1-ACYL-SN-GLYCEROL 3-PHOSPHATE = CoA FT + 1,2-DIACYL-SN-GLYCEROL 3-PHOSPHATE]. N-TERMINUS: COULD BE FT GENERATE SERINE AND PHOSPHATE FROM PHOSPHOSERINE; MAY FT CATALYZE THE LAST STEP IN THE BIOSYNTHESIS OF SERINE FROM FT CARBOHYDRATES (THE REACTION MECHANISM COULD BE PROCEED VIA FT THE FORMATION OF A PHOSPHORYL-ENZYME INTERMEDIATES) FT [CATALYTIC ACTIVITY 1: PHOSPHOSERINE + H(2)O = SERINE + FT PHOSPHATE]." FT /EC_number="3.1.3.3" FT /EC_number="2.3.1.51" FT /note="Rv2483c, (MTV008.39c), len: 580 aa. Possible plsC, a FT transmembrane phospholipid biosynthesis bifunctionnal FT enzyme, including L-3-phosphoserine phosphatase (EC FT 3.1.3.3) and 1-acyl-Sn-glycerol-3-phosphate acyltransferase FT (EC 2.3.1.51), equivalent to Q9X7A9|PLSC|ML1245 PUTATIVE FT ACYLTRANSFERASE from Mycobacterium leprae (579 aa), FASTA FT scores: opt: 2835, E(): 9.2e-153, (77.15% identity in 573 FT aa overlap). C-terminal end is similar to many FT 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASES FT (LYSOPHOSPHATIDIC ACIDACYLTRANSFERASES) e.g. Q9SDQ2 from FT Limnanthes floccosa (281 aa), FASTA scores: opt: 378, E(): FT 3.1e-14, (30.0% identity in 230 aa overlap) and FT Q42868|PLSC_LIMAL from Limnanthes alba (White meadowfoam) FT (281 aa), FASTA scores: opt: 374, E(): 5.2e-14, (30.55% FT identity in 221 aa overlap); and the N-terminal end is FT similar to many SERB FAMILY PROTEINS e.g. AAK44749|MT0526 FT from Mycobacterium tuberculosis strain CDC1551 (308 aa), FT FASTA scores: opt: 356, E(): 5.8e-13, (32.5% identity in FT 298 aa overlap) and Q49823|ML2424 from Mycobacterium leprae FT (300 aa), FASTA scores: opt: 346, E(): 2.1e-12, (32.0% FT identity in 278 aa overlap). So belongs to the FT 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE FAMILY and FT may belong to the SERB FAMILY." FT /db_xref="GOA:O53208" FT /db_xref="InterPro:IPR006385" FT /db_xref="UniProtKB/TrEMBL:O53208" FT /protein_id="CAA16060.1" FT /translation="MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLD FT GTLVAGFTAVILTQERLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAALAGRL FT LTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFLGIN FT NMLTNKFETNEDGILTGGVLKPILWCPGKATAVQRFAAEHDIDLKDSYFYADGDEDVAL FT MYLVGNPRPTNPEGKMAAVAKRRGWPILKFNSRGGVGIRRQLRTLAGLSTIVPVAAGAV FT GIGVLTGSRRRGVNFFTSTFSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHRNQVDPV FT IAGALVRDNWVGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGL FT SIVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNSTTINPGTVD FT VAVFPPIPVDDWTLDALPDRIAEVRQLYLDTLADWPVDGLPAVDLYAEQKAARKARAQV FT AKATAKRVPAKKAPAKSAANKGAAATKAATKKASPKAKPSESKIAGKDGEASASPSSSA FT KGRS" FT CDS complement(17983..19458) FT /transl_table=11 FT /locus_tag="Rv2484c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2484c, (MTV008.40c), len: 491 aa. Conserved FT hypothetical protein, highly similar or similar to many FT Mycobacterial hypothetical proteins e.g. FT Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from FT Mycobacterium leprae (491 aa), FASTA scores: opt: 2459, FT E(): 3e-138, (75.15% identity in 483 aa overlap); FT O53304|YU87_MYCTU|Rv3087|MTV013.08 from Mycobacterium FT tuberculosis (472 aa), FASTA scores: opt: 527, E(): FT 8.1e-24, (29.1% identity in 485 aa overlap); FT O53305|YU88_MYCTU|Rv3088|MT3173|MTV013.09 from FT Mycobacterium tuberculosis (474 aa), FASTA scores: opt: FT 370, E(): 1.6e-14, (26.05% identity in 422 aa overlap); FT etc." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/Swiss-Prot:O53209" FT /protein_id="CAA16061.1" FT /translation="MAESGESPRLSDELGPVDYLMHRGEANPRTRSGIMALELLDGTPD FT WDRFRTRFENASRRVLRLRQKVVVPTLPTAAPRWVVDPDFNLDFHVRRVRVSGPATLRE FT VLDLAEVILQSPLDISRPLWTATLVEGMADGRAAMLLHVSHAVTDGVGGVEMFAQIYDL FT ERDPPPRSTPPQPIPEDLSPNDLMRRGINHLPIAVVGGVLDALSGAVSMAGRAVLEPVS FT TVSGILGYARSGIRVLNRAAEPSPLLRRRSLTTRTEAIDIRLADLHKAAKAGGGSINDA FT YLAGLCGALRRYHEALGVPISTLPMAVPVNLRAEGDAAGGNQFTGVNLAAPVGTIDPVA FT RMKKIRAQMTQRRDEPAMNIIGSIAPVLSVLPTAVLEGITGSVIGSDVQASNVPVYPGD FT TYLAGAKILRQYGIGPLPGVAMMVVLISRGGWCTVTVRYDRASVRNDELFAQCLQAGFD FT EILALAGGPAPRVLPASFDTQGAGSVPRSVSGS" FT CDS complement(19687..20952) FT /transl_table=11 FT /gene="lipQ" FT /locus_tag="Rv2485c" FT /product="PROBABLE CARBOXYLESTERASE LIPQ" FT /function="UNKNOWN; LIPOLYTIC ENZYME INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="3.1.-.-" FT /note="Rv2485c, (MTV008.41c), len: 421 aa. Probable lipQ, FT carboxylesterase protein (lipase) (EC 3.1.-.-). Similar FT (greater at the C-terminal end) to AAK46626|MT2342 PUTATIVE FT CARBOXYLESTERASE from Mycobacterium tuberculosis strain FT CDC1551 (431 aa), FASTA scores: opt: 1134, E(): 4.3e-60, FT (46.25% identity in 428 aa overlap); and FT Q50681|Rv2284|MTCY339.26c HYPOTHETICAL PROTEIN from M. FT tuberculosis strain H37Rv (431 aa), FASTA scores: opt: FT 1134, E(): 4.3e-60, (46.25% identity in 428 aa overlap). FT Also similar in part to other putative lipases/esterases FT e.g. AAK44451|MT0230 from Mycobacterium tuberculosis strain FT CDC1551 (403 aa), FASTA scores: opt: 763, E(): 4.6e-38, FT (37.95% identity in 390 aa overlap); Q9RY19|DR0133 from FT Deinococcus radiodurans (296 aa), FASTA scores: opt: 392, FT E(): 4e-16, (33.7% identity in 276 aa overlap); FT Q9Z545|SC9B2.14 from Streptomyces coelicolor (502 aa) FASTA FT scores: opt: 279, E(): 3.2e-09, (31.15% identity in 292 aa FT overlap); etc." FT /db_xref="GOA:O53210" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:O53210" FT /protein_id="CAA16062.1" FT /translation="MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGSPCA FT IGWVAGWLSAEFPARVVTGHALSRISPRSIGRFGTSWAAQRADQILHAALVDAFGPDFR FT DLVWHPTGEQSEAARRSGLLNLPHIPGPHRRYAAQTSDIPYGPGGRENLLDIWRRPDLA FT PGRRAPVLIQVPGGAWTINGKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAHIVDV FT KRAIAWVRENIADYGGDPDFITITGGSAGAHLAALAALSANDPALQPGFESADTAVQAA FT APYYGVYDLTNAENMHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYVHSEAPPFFVLH FT GEKDPMVPSAQSRAFSAALRDAGAATVSYAELPNAHHAFDLAATVRSRMVAEAVSDFLG FT VIYGRRMGARKGSLALSSPPAS" FT tRNA 21140..21213 FT /gene="tRNA-Arg(TCT)" FT /product="transfer RNA-Arg(TCT)" FT /anticodon=(pos:21174..21176,aa:Arg) FT CDS 21314..22084 FT /transl_table=11 FT /gene="echA14" FT /locus_tag="Rv2486" FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA14 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv2486, (MTV008.42), len: 256 aa. Probable echA14, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. FT P24162|ECHH_RHOCA2|FADB1 from Rhodobacter capsulatus FT (Rhodopseudomonas capsulata) (257 aa), FASTA scores; opt: FT 453, E(): 3.8e-23, (39.4% identity in 259 aa overlap); FT Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa), FASTA FT scores: opt: 404, E(): 5.7e-17, (37.5% identity in 224 aa FT overlap); P77467|PAAG_ECOLI from Escherichia coli (262 aa), FT FASTA scores: opt: 401, E(): 8.3e-17, (36.3% identity in FT 259 aa overlap); etc. Contains PS00166 Enoyl-CoA FT hydratase/isomerase signature. BELONGS TO THE ENOYL-COA FT HYDRATASE/ISOMERASE FAMILY." FT /db_xref="GOA:P64018" FT /db_xref="HSSP:1MJ3" FT /db_xref="InterPro:IPR018376" FT /db_xref="UniProtKB/Swiss-Prot:P64018" FT /protein_id="CAA16063.1" FT /translation="MAQYDPVLLSVDKHVALITVNDPDRRNAVTDEMSAQLRAAIQRAE FT GDPDVHAVVVTGAGKAFCAGADLSALGAGVGDPAEPRLLRLYDGFMAVSSCNLPTIAAV FT NGAAVGAGLNLALAADVRIAGPAALFDARFQKLGLHPGGGATWMLQRAVGPQVARAALL FT FGMCFDAESAVRHGLALMVADDPVTAALELAAGPAAAPREVVLASKATMRATASPGSLD FT LEQHELAKRLELGPQAKSVQSPEFAARLAAAQHR" FT misc_feature 21614..21676 FT /note="PS00166 Enoyl-CoA hydratase/isomerase signature" FT CDS complement(22265..24349) FT /transl_table=11 FT /gene="PE_PGRS42" FT /locus_tag="Rv2487c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2487c, (MTV008.43c), len: 694 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT Gly-rich proteins (see citation below), similar to many FT e.g. AAK47245|MT2919 PE_PGRS family protein from FT Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA FT scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa FT overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7D724" FT /protein_id="CAE55495.1" FT /translation="MSLVIATPQLLATAALDLASIGSQVSAANAAAAMPTTEVVAAAAD FT EVSAAIAGLFGAHARQYQALSVQVAAFHEQFVQALTAAAGRYASTEAAVERSLLGAVNA FT PTEALLGRPLIGNGADGTAPGQPGAAGGLLFGNGGNGAAGGFGQTGGSGGAAGLIGNGG FT NGGAGGTGAAGGAGGNGGWLWGNGGNGGVGGTSVAAGIGGAGGNGGNAGLFGHGGAGGT FT GGAGLAGANGVNPTPGPAASTGDSPADVSGIGDQTGGDGGTGGHGTAGTPTGGTGGDGA FT TATAGSGKATGGAGGDGGTAAAGGGGGNGGDGGVAQGDIASAFGGDGGNGSDGVAAGSG FT GGSGGAGGGAFVHIATATSTGGSGGFGGNGAASAASGADGGAGGAGGNGGAGGLLFGDG FT GNGGAGGAGGIGGDGATGGPGGSGGNAGIARFDSPDPEAEPDVVGGKGGDGGKGGSGLG FT VGGAGGTGGAGGNGGAGGLLFGNGGNGGNAGAGGDGGAGVAGGVGGNGGGGGTATFHED FT PVAGVWAVGGVGGDGGSGGSSLGVGGVGGAGGVGGKGGASGMLIGNGGNGGSGGVGGAG FT GVGGAGGDGGNGGSGGNASTFGDENSIGGAGGTGGNGGNGANGGNGGAGGIAGGAGGSG FT GFLSGAAGVSGADGIGGAGGAGGAGGAGGSGGEAGAGGLTNGPGSPGVSGTEGMAGAPG FT " FT CDS complement(24431..27844) FT /transl_table=11 FT /locus_tag="Rv2488c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (LUXR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv2488c, (MTV008.44c), len: 1137 aa. Probable FT transcriptional regulatory protein, belonging to luxR FT family, similar to many in Mycobacterium tuberculosis e.g. FT AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: FT opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa FT overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 FT aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% FT identity in 1089 aa overlap); AAK45665|MT1402 from strain FT CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190, FT (52.0% identity in 1093 aa overlap); etc. Also similar to FT transcriptional regulatory proteins luxR-family from other FT organisms e.g. Q9CBP3|ML1753 from Mycobacterium leprae FT (1106 aa), FASTA scores: opt: 2823, E(): 1.5e-156, (50.35% FT identity in 1116 aa overlap); Q9KYF4|SCD72A.02 from FT Streptomyces coelicolor (1114 aa), FASTA scores: opt: 915, FT E(): 1.7e-45, (30.7% identity in 1143 aa overlap); etc. FT Some similarity with Q9KXP6|SC9C5.28 HYPOTHETICAL 81.8 KDA FT PROTEIN from Streptomyces coelicolor (750 aa), FASTA FT scores: opt: 1085, E(): 1.6e-55, (35.45% identity in 722 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), PS00622 Bacterial regulatory proteins, luxR FT family signature, probable coiled-coil from aa 585 to 616 FT and probable helix-turn-helix motif at aa 1086 to 1107 FT (score 1206, +3.29 SD). BELONGS TO THE LUXR/UHPA FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:O53213" FT /db_xref="HSSP:1FSE" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:O53213" FT /protein_id="CAA16065.1" FT /translation="MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSA FT DGVSELVPTGTVTLLLADIEGATHLPGSQLDTTAIAKLDRTLTELVREHRGVCPVEQGE FT GDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSSPDEGNCVGPTIDRTARL FT RELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGTYRLDDLPRPERVVQLCHPDLHNAFP FT PLRTRKVVGAHCLPAQLTRLVGRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVAS FT AVADGYPDGVWYVNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVL FT DNCEHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHGEAIELFTDR FT AREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALALTEIVDSLHDRFRLLT FT GGSRIAVRRQQTMRASVDWSHALLTGPEQVLFRRLAVFPSGFDLDGAQAAAAGGDVQRY FT EVVDLLSLLADKSLVVTDDSDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAA FT VAAGLDAPSVAGHERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGR FT LQEGLAWFAAALADHDAHPAGADPGLYARALADRALIDAVAGITDRLDDAQKALAIARD FT IEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAG FT EGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESD FT AAHDMVSSCAGQACLAHALAHRGDTEAAAAAQASIDTAVGLSPVLSGSACSALVFATLA FT AGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGV FT HRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAYLWVPDILECLASVMADAGSN FT REAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGDSEFDDAWAEGTALSIDE FT AIAYAQRGRGARKRPTSGWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTH FT VYTKLGLSSRLQLAQQAARRGESERGPSRP" FT misc_feature complement(24512..24595) FT /note="PS00622 Bacterial regulatory proteins, luxR family FT signature" FT misc_feature complement(27026..27049) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT repeat_region 27635..27882 FT /note="248 bp direct repeat 2" FT CDS complement(27810..28109) FT /transl_table=11 FT /locus_tag="Rv2489c" FT /product="HYPOTHETICAL ALANINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2489c, (MTV008.45c), len: 99 aa. Hypothetical FT unknown ala-rich protein." FT /db_xref="UniProtKB/TrEMBL:O53214" FT /protein_id="CAA16066.1" FT /translation="MGVTAKAAEAAAPSSSFPSLRKPHRAGDSADRSAGDFDGTAHDAV FT VSVLAGDAASTGGLTIASGQHGHCRSAAMARRSPNASTKARRTHGPAAKRFRAI" FT CDS complement(28218..33200) FT /transl_table=11 FT /gene="PE_PGRS43" FT /locus_tag="Rv2490c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2490c, (MTV008.46c), len: 1660 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS-subfamily of FT Gly-rich proteins (see citation below), similar to many FT e.g. AAK47971|MT3612.1 PE_PGRS family protein from FT Mycobacterium tuberculosis strain CDC1551 (1715 aa), FASTA FT scores: opt: 5161, E(): 1.5e-187, (51.7% identity in 1752 FT aa overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FD4" FT /protein_id="CAE55496.1" FT /translation="MSYVIATPEMMATAAFDLARIGSQVSAASAVAAMPTTEVVAAGAD FT EVSAGIAALFSAHAQEYQALSAQAAAFHDQFVHTLTAAARWYTATEIANAAAMRVVLGA FT VNAPTQTLLGRPLIGDGAHGTAPGQPGGAGGLLFGNGGNGAAGAVGQVGGAGGAAGLFG FT IGGAGGAGGAGAPGGTGGTGGWLAGGGGVGGMGGAGGGAGGAGGNAGLFGNGGAGGAGG FT AGGGAGGAGGNAGWFGHGGAGGVGGVGAAGANGATPGQDGAAGVAGSDDGAGGDGLAGS FT DGGDGGAGGVGGNGGRGGWLLGNGGAGGVGGVGGAGGAGAAGGAGGAGATGINGPAGIS FT AAGGDGGAGGNGGAGGNGGVGGAGGAGGSAGLLGYVGRAGDGGAGGGGGLGGAPGDGGA FT GGNGGSWLAAGDGGAGGHGGDPGLGGAGGAGGASGGAGARAGANGLAAGNDGPVSGGNG FT GKGGNGAHAPVAGGHGGNGGAGGNGGLVGDGGAGGHGGDGAAGAGYADMTAIFLGSSGT FT PGEDGGNGGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFNAVLVSDGGNGGD FT GGAGGRGGDGGAGGAGGDAPAGRAGSQGVGGDGGAGGAGGAPGNGGSGGRGDMAFKDGD FT GGAGGDGGDPGAGGKGGAGGAGATEGVTGATGATVHSGGNGGKGGNGADATVAGANGGK FT GGAGGNGGLVGDGGAGGDGGSGAAGANGANVGEDGADGTLSGQPGEGSEANGGQGGVGG FT GGAGGAGGDGGAGSSALGSGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGGPGGKGGA FT GGAGGAGASGGGGGKGASGADSAEAVGGAGGKGGDGGVGGVGGDGGPGGDGGAGGAAPA FT GQVGSHGVGGVGGDGGLGGAGGNGGDGGHGSDGGDGGDGGDPGAGGLGGLGGDSGNGTR FT AASGVDASDHGPGSGGNGGNGGNGAQASVAGGAGGNGGDGGNAGRVGDGGAGGNGGDGA FT AGANGANSGAPGSDALALGQPGGNGGQGDAGQAGGAGGAGGAGGAGGSVSGDGGAGGNG FT GAGGNGGVGASGGAGARGANGIDSIGGTGGAGGGGGDGGAGGVGGHGGDGGVGGAAPSG FT TVGSHGTGGVGGDGGLGGAGGVGGAGGNGGIGITVGGAGGAGGNGGDPGAGGRGGLGGD FT SGNGTSAANGVDASKHGPLTGGDGGVGGNGAKAAAAGGDGGQGGDGGNAGLFGDGGAGG FT DGADGTAAEALGGDGGAGGAGGKGGDAGDIGDGGDGGKGGDGAHGALGGLTVAGGNGGA FT GGAGGAGGAGGAFLGDGGNGGAGGQGGAGRGGSPGGGGGVGGHGGAGGDAGMNGGGGTG FT GQGGNGAAGGAGWSPDSDLKGFDGFDGGSGGAGGDGGAGGAGGTQTGDGGDGGAGGLGG FT AGGVGGNGVDGFDINETTGRDGGDGGDGGYGGWGGAGGNGGAGGSAPAGEVGNRGVGGD FT GGDGGSGGDAGNGGLGGDGFTYLADFDGEPGGDGGDGGDGGWGRPGGQGGFGSTSGAHG FT KAGFGAPGGDGGDGGNGGHGGDGNGSFADAGDGGPGGNGGNGGLGGAGRDGGAPGGDGG FT DGGTGGSGGFGAPPPRSIGGGDGGDGGRGGDGGRGAGGLTSGGVGSSGESGGSGNGRGD FT PGSGGSGGEGGEGGPSISVNVT" FT repeat_region 33332..33589 FT /note="258 bp direct repeat 2" FT CDS 33629..34252 FT /transl_table=11 FT /locus_tag="Rv2491" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2491, (MTV008.47), len: 207 aa. Conserved FT hypothetical protein, similar in part to other hypothetical FT proteins e.g. O29139|AF1126 from Archaeoglobus fulgidus FT (151 aa), FASTA scores: opt: 293, E(): 2.8e-11, (42.85% FT identity in 126 aa overlap); O66531|AQ_134 from Aquifex FT aeolicus (151 aa), FASTA scores: opt: 261, E(): 2.6e-09, FT (37.75% identity in 106 aa overlap); Q9HKU3|TA0501 from FT Thermoplasma acidophilum (161 aa), FASTA scores: opt: 260, FT E(): 3.2e-09, (35.9% identity in 117 aa overlap); etc." FT /db_xref="InterPro:IPR005268" FT /db_xref="UniProtKB/TrEMBL:O53216" FT /protein_id="CAA16068.1" FT /translation="MVDTSAPASRLDTDPRRAHVSLSKHPYQIGVFGSGTIGPRVYELA FT YQVGAEIAKQGHILISGGMTGTMEASSRGASDADGLVVGVLPGDKFTDGNAYSTIKILS FT GMQFARNYITGLSCHGAIVVGGSSGAYEEARRVWEGRGPVVVLANSGSPTGASAQMLSM FT QEIFGVAFPEDKPKPWRVFSAATPAESVSLVIGLIRKGYAQHEP" FT CDS 34242..34994 FT /transl_table=11 FT /locus_tag="Rv2492" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2492, (MTV008.48), len: 250 aa. Hypothetical FT unknown protein." FT /db_xref="GOA:O53217" FT /db_xref="UniProtKB/TrEMBL:O53217" FT /protein_id="CAA16069.1" FT /translation="MSRRIINEFGVQIYGATIGDTWAGLVRAVLDLGSQCFDEDRERIA FT LSNVRIKSSVQNYPDLTIEEHCNSAQLKAMLDFMFNTDTMEDIDVVKSFSRGAKSYHRR FT IKEGRMIEFVIERLSLIPESKKAVVVFPTYEDYAAVMRNHRDDYLPCLVSIQFRLLPDG FT KDYVFHTTFYSRSMDAWQKGHGNLLSIAKLSDWVRENVSARIGRKIMLGPLDGMICDVH FT IYKETYAEACKRLANLDLRRTQFDAVRN" FT CDS 35047..35268 FT /transl_table=11 FT /locus_tag="Rv2493" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2493, (MTV008.49), len: 73 aa. Conserved FT hypothetical protein, highly similar to AAK46916|MT2606 FT HYPOTHETICAL 8.8 KDA PROTEIN from Mycobacterium FT tuberculosis strain CDC1551 (74 aa), FASTA scores: opt: FT 234, E(): 4e-09, (56.95% identity in 74 aa overlap); and FT similar to O53373|Rv3321c|MTV016.21c HYPOTHETICAL 8.8 KDA FT PROTEIN from Mycobacterium tuberculosis strain H37Rv (80 FT aa), FASTA scores: opt: 126, E(): 0.055, (30.75% identity FT in 78 aa overlap); and with weak similarity with other FT Mycobacterial hypothetical proteins e.g. Q9CCR7|ML0525 from FT Mycobacterium leprae (58 aa), FASTA scores: opt: 115, E(): FT 0.22, (47.75% identity in 44 aa overlap); etc." FT /db_xref="UniProtKB/TrEMBL:O53218" FT /protein_id="CAA16070.1" FT /translation="MRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEA FT DDGLPVIRVPAGTPPITPEMVRRALDED" FT CDS 35274..35699 FT /transl_table=11 FT /locus_tag="Rv2494" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2494, (MTV008.50), len: 141 aa. Conserved FT hypothetical protein, similar to other Mycobacterium FT tuberculosis hypothetical proteins e.g. FT P95023|EMBL:Z83863|MTCY159.26|Rv2530c (139 aa) FASTA FT scores: opt: 380 E(): 6.6e-19, (48.0% identity in 125 aa FT overlap); O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: FT opt: 287, E(): 1.3e-12, (41.6% identity in 125 aa overlap); FT AAK46915|MT2605 (strain CDC1551) (139 aa) FASTA scores: FT opt: 380, E(): 6.6e-19 (48.0% identity in 125 aa overlap); FT etc." FT /db_xref="InterPro:IPR006226" FT /db_xref="UniProtKB/TrEMBL:O53219" FT /protein_id="CAA16071.1" FT /translation="MALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGF FT VRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFLADDVSLVDDDVPLIVGYRQVTDAH FT LLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL" FT CDS complement(35722..36903) FT /transl_table=11 FT /gene="pdhC" FT /locus_tag="Rv2495c" FT /product="PROBABLE DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE E2 FT COMPONENT PDHC (LIPOATE ACETYLTRANSFERASE) FT (THIOLTRANSACETYLASE A)" FT /function="INVOLVED IN ENERGY METABOLISM. THE PYRUVATE FT DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF FT PYRUVATE TO ACETYL-CoA & CO(2). IT CONTAINS MULTIPLE COPIES FT OF THREE ENZYMATIC COMPONENTS: PYRUVATE DEHYDROGENASE (E1), FT DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2) & LIPOAMIDE FT DEHYDROGENASE (E3) [CATALYTIC ACTIVITY: ACETYL-CoA + FT DIHYDROLIPOAMIDE = CoA + S-ACETYLDIHYDROLIPOAMIDE]." FT /EC_number="2.3.1.12" FT /note="Rv2495c, (MTCY07A7.01c-MTV008.51c), len: 393 aa. FT Probable pdhC, dihydrolipoamide S-acetyltransferase, e2 FT component (EC 2.3.1.12), similar to others e.g. FT Q9XA49|SCGD3.30c from Streptomyces coelicolor (491 aa) FT FASTA scores: opt: 615, E(): 1.2e-28, (36.45% identity in FT 491 aa overlap; several gaps); FT P19262|ODO2_YEAST|KGD2|YDR148C|YD8358.05c from FT Saccharomyces cerevisiae (Baker's yeast) (463 aa) FASTA FT scores: opt: 533, E(): 7.1e-24, (28.55% identity in 396 aa FT overlap); Q9HN75|DSA|VNG2219G from Halobacterium sp. strain FT NRC-1 (478 aa), FASTA scores: opt: 521, E(): E(): 3.7e-23, FT (30.25% identity in 486 aa overlap; in part); etc. BELONGS FT TO THE 2-OXOACID DEHYDROGENASE FAMILY." FT /db_xref="GOA:O06159" FT /db_xref="HSSP:1LAB" FT /db_xref="InterPro:IPR001078" FT /db_xref="UniProtKB/TrEMBL:O06159" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08928.1" FT /translation="MSGEDSIRSFPVPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVE FT TAKAEVEIPSPYAGRIVELGGAEGDVLKVGAELVRIDTGPTAVAQPNGEGAVPTLVGYG FT ADTAIETSRRTSRPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGGVGA FT GPDVRPVHGVHARMAEKMTLSHKEIPTAKASVEVICAELLRLRDRFVSAAPEITPFALT FT LRLLVIALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQDKNTR FT ELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVINHPEAAILGLGAIK FT PRPVVVGGEVVARPTMTLTCVFDHRVVDGAQVAQFMCELRDLIESPETALLDL" FT CDS complement(36900..37946) FT /transl_table=11 FT /gene="pdhB" FT /locus_tag="Rv2496c" FT /product="PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT FT (BETA SUBUNIT) PDHB (PYRUVATE DECARBOXYLASE) (PYRUVATE FT DEHYDROGENASE) (PYRUVIC DEHYDROGENASE)" FT /function="INVOLVED IN ENERGY METABOLISM. THE PYRUVATE FT DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF FT PYRUVATE TO ACETYL-CoA & CO(2). IT CONTAINS MULTIPLE COPIES FT OF THREE ENZYMATIC COMPONENTS: PYRUVATE DEHYDROGENASE (E1), FT DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2) & LIPOAMIDE FT DEHYDROGENASE (E3). [CATALYTIC ACTIVITY: PYRUVATE + FT LIPOAMIDE = S-ACETYL-DIHYDRO-LIPOAMIDE + CO(2)]." FT /EC_number="1.2.4.1" FT /note="Rv2496c, (MTCY07A7.02c), len: 348 aa. Probable pdhB, FT pyruvate dehydrogenase e1 component, beta subunit (EC FT 1.2.4.1), similar to others e.g. Q9Y8I6||PDHB from FT Halobacterium volcanii (Haloferax volcanii) (327 aa) FASTA FT scores: opt: 1050, E(): 6.4e-60, (49.7% identity in 324 aa FT overlap); Q9KG98|BH0214 from Bacillus halodurans (328 aa), FT FASTA scores: opt: 987, E(): 6.9e-56, (45.7% identity in FT 324 aa overlap); Q9HN76|PDHB|VNG2218G from Halobacterium FT sp. strain NRC-1 (297 aa), FASTA scores: opt: 968, E(): FT 1.1e-54, (51.2% identity in 297 aa overlap); FT P21874|ODPB_BACST|PDHB PYRUVATE DEHYDROGENASE E1 COMPONENT FT from Bacillus stearothermophilus (324 aa), FASTA scores: FT opt: 951, E(): 1.4e-53, (47.6% identity in 321 aa overlap); FT etc. Also similar to Q9XA61|SCGD3.17c PUTATIVE FT BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1, BETA FT SUBUNIT (2-oxoisovalerate dehydrogenase) (EC 1.2.4.4) from FT Streptomyces coelicolor, (326 aa), FASTA scores: opt: 1178, FT E(): 4.1e-68, (55.0% identity in 322 aa overlap); FT Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID FT DEHYDROGENASE E1 BETA SUBUNIT from Streptomyces coelicolor FT (334 aa), FASTA scores: opt: 1173, E(): 8.8e-68, (55.6% FT identity in 320 aa overlap); Q53593|BKDB E1-BETA FT BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE from FT Streptomyces avermitilis (334 aa), FASTA scores: opt: 1132, FT E(): 3.7e-65, (55.0% identity in 320 aa overlap); etc." FT /db_xref="GOA:O06160" FT /db_xref="HSSP:1IK6" FT /db_xref="InterPro:IPR005475" FT /db_xref="UniProtKB/TrEMBL:O06160" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08929.1" FT /translation="MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADER FT VLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQ FT FDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTA FT GLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHGRGMVDTSRPEPPIGHAMVRRS FT GTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVV FT MHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGPDRLLDC FT VERVLRQP" FT CDS complement(37957..39060) FT /transl_table=11 FT /gene="pdhA" FT /locus_tag="Rv2497c" FT /product="PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT FT (ALPHA SUBUNIT) PDHA (PYRUVATE DECARBOXYLASE) (PYRUVATE FT DEHYDROGENASE) (PYRUVIC DEHYDROGENASE)" FT /function="INVOLVED IN ENERGY METABOLISM. THE PYRUVATE FT DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF FT PYRUVATE TO ACETYL-CoA & CO(2). IT CONTAINS MULTIPLE COPIES FT OF THREE ENZYMATIC COMPONENTS: PYRUVATE DEHYDROGENASE (E1), FT DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2) & LIPOAMIDE FT DEHYDROGENASE (E3) [CATALYTIC ACTIVITY: PYRUVATE + FT LIPOAMIDE = S-ACETYL-DIHYDRO-LIPOAMIDE + CO(2)]." FT /EC_number="1.2.4.1" FT /note="Rv2497c, (MTCY07A7.03c), len: 367 aa. Probable pdhA, FT pyruvate dehydrogenase e1 component, alpha subunit (EC FT 1.2.4.1), similar to many e.g. Q9Y8I5|PDHA from FT Halobacterium volcanii (Haloferax volcanii) (368 aa) FASTA FT scores: opt: 961, E(): 1.3e-52, (45.6% identity in 351 aa FT overlap); BAB40585 from Bacillus sp. UTB2301 (356 aa) FASTA FT scores: opt: 947, E(): 9.1e-52, (43.1% identity in 355 aa FT overlap); Q9KG99|BH0213 from Bacillus halodurans (367 aa), FT FASTA scores: opt: 896, E(): 1.4e-48, (42.65% identity in FT 340 aa overlap); etc. Also similar to several PUTATIVE FT BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASES E1, BETA FT SUBUNIT (EC 1.2.4.4), alternate name : 2-oxoisovalerate FT dehydrogenase, e.g. Q53592|BKDA from Streptomyces FT avermitilis (381 aa), FASTA scores: opt: 980, E(): 8.5e-54, FT (45.65% identity in 370 aa overlap); etc." FT /db_xref="GOA:O06161" FT /db_xref="HSSP:1OLX" FT /db_xref="InterPro:IPR017596" FT /db_xref="UniProtKB/TrEMBL:O06161" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08930.1" FT /translation="MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLR FT WLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRELG FT VYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDEDS FT VTVAFLGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAI FT GYGMPGIRVDGNDVLACYAVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQ FT EEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEV FT FTTVYAEITPGLQAQREQLRAELARTD" FT CDS complement(39319..40140) FT /transl_table=11 FT /gene="citE" FT /locus_tag="Rv2498c" FT /product="PROBABLE CITRATE (PRO-3S)-LYASE (BETA SUBUNIT) FT CITE (CITRASE) (CITRATASE) (CITRITASE) (CITRIDESMOLASE) FT (CITRASE ALDOLASE)" FT /function="INTERCONVERSION OF ACETATE AND OXALOACETATE FROM FT CITRATE [CATALYTIC ACTIVITY: CITRATE = ACETATE + FT OXALOACETATE]." FT /EC_number="4.1.3.6" FT /note="Rv2498c, (MTCY07A7.04c), len: 273 aa. Probable citE, FT citrate lyase, beta subunit (EC 4.1.3.6), similar to others FT e.g. Q9S3L3|CITE from Corynebacterium glutamicum FT (Brevibacterium flavum) (217 aa), FASTA scores: opt: 565, FT E(): 1.5e-28, (41.85% identity in 215 aa overlap); FT Q9HRM8|CITE|VNG0627G from Halobacterium sp. strain NRC-1 FT (303 aa), FASTA scores: opt: 535, E(): 1.5e-26, (41.65% FT identity in 276 aa overlap); Q9S2U9|SC4G6.02 from FT Streptomyces coelicolor (274 aa), FASTA scores: opt: 426, FT E(): 1e-19, (37.6% identity in 274 aa overlap); FT P77770|CILB_ECOLI from Escherichia coli (307 aa), FASTA FT scores: opt: 265, E(): 1.5e-10, (32.8% identity in 265 aa FT overlap); etc. Also similar to Rv3075c|MTCY22D7.06 from FT Mycobacterium tuberculosis, FASTA score: (35.2% identity in FT 264 aa overlap)." FT /db_xref="GOA:O06162" FT /db_xref="InterPro:IPR015813" FT /db_xref="PDB:1U5H" FT /db_xref="UniProtKB/Swiss-Prot:O06162" FT /protein_id="CAB08916.1" FT /translation="MNLRAAGPGWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQKP FT AARNALRDTPLDPERTVVRINAGGTADQARDLEALAGTAYTTVMLPKAESAAQVIELAP FT RDVIALVETARGAVCAAEIAAADPTVGMMWGAEDLIATLGGSSSRRADGAYRDVARHVR FT STILLAASAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKAYR FT PSHEKLAWARRVLAASRSERGAFAFEGQMVDSPVLTHAETMLRRAGEATSE" FT CDS complement(40137..40694) FT /transl_table=11 FT /locus_tag="Rv2499c" FT /product="POSSIBLE OXIDASE REGULATORY-RELATED PROTEIN" FT /function="UNKNOWN" FT /note="Rv2499c, (MTCY07A7.05c), len: 185 aa. Possible FT oxidase regulatory-related protein, similar to many maoC FT MONOAMINE OXIDASE REGULATORY PROTEIN e.g. Q9RUZ1|DR1239 FT MAOC-RELATED PROTEIN from Deinococcus radiodurans (160 aa), FT FASTA scores: opt: 519, E(): 7.6e-28, (58.1% identity in FT 148 aa overlap); BAB48392|MLR0905 Probable monoamine FT oxidase regulatory protein from Rhizobium loti FT (Mesorhizobium loti) (150 aa), FASTA scores: opt: 480, E(): FT 2.9e-25, (49.0% identity in 149 aa overlap); FT Q9HN18|MAOC1|VNG2290G MONOAMINE OXIDASE REGULATORY-LIKE FT from Halobacterium sp. strain NRC-1 (208 aa), FASTA scores: FT opt: 419, E(): 4.6e-21, (45.6% identity in 158 aa overlap); FT P77455|MAOC_ECOLI|PAAZ|B1387 MaoC protein (Phenylacetic FT acid degradation protein paaZ) from Escherichia coli strain FT K12 (681 aa), FASTA scores: opt: 252, E(): 1.9e-09, (36.0% FT identity in 172 aa overlap); etc. But also similar to other FT proteins with different putative functions e.g. FT Q9HRM9|MAOC2|VNG0626G MOLYBDENUM COFACTOR BIOSYNTHESIS FT PROTEIN from Halobacterium sp strain NRC-1 (157 aa), FASTA FT scores: opt: 380, E(): 1.5e-18, (45.75% identity in 153 aa FT overlap); Q9KIF1 FKBR2 from Streptomyces hygroscopicus var. FT ascomyceticus (175 aa), FASTA scores: opt: 355, E(): FT 7.6e-17, (42.0% identity in 150 aa overlap); FT CAC36828|Q99Q03|SAPE Spore associated protein from FT Streptomyces coelicolor (174 aa), FASTA scores: opt: 318, FT E(): 2.2e-14, (41.45% identity in 152 aa overlap); etc." FT /db_xref="GOA:O06163" FT /db_xref="InterPro:IPR002539" FT /db_xref="UniProtKB/TrEMBL:O06163" FT /protein_id="CAB08917.1" FT /translation="MTKHAGDRESDDAVSACRVAGSTVGRRILQRGLWFEEFQIGTTYL FT HRPGRTVTEADNVLFTTLTMNTQSLHLDAAWAGQQPGFRGERLVNSMFTLSTMVGLSVA FT QLTLGTIVANLGFSEVSFPKPVFHGDTLYAETVCTGKRESKSRPGEGIVTLEHIARNQH FT GEVVARAVRTTLVQKQSIKEAQ" FT CDS complement(40691..41875) FT /transl_table=11 FT /gene="fadE19" FT /locus_tag="Rv2500c" FT /standard_name="mmgC" FT /product="POSSIBLE ACYL-CoA DEHYDROGENASE FADE19 (MMGC)" FT /function="UNKNOWN, BUT SEEMS INVOLVED IN METABOLISM OF FT SMALL BRANCHED-CHAIN FATTY ACIDS AND MACROLIDE ANTIBIOTIC FT PRODUCTION. CATALYSES THE ALPHA, BETA-DEHYDROGENETION OF FT ACYL-CoA ESTERS AND TRANSFER ELECTRONS TO ETF, THE ELECTRON FT TRANSFER PROTEIN." FT /EC_number="1.3.99.-" FT /note="Rv2500c, (MTCY07A7.06c), len: 394 aa. Possible FT fadE19 (alternate gene name: , acyl-CoA dehydrogenase (EC FT 1.3.99.-), similar to many e.g. Q9XCG6|ACDH from FT Streptomyces coelicolor (386 aa), FASTA scores: opt: 1714, FT E(): 1.1e-98, (69.45% identity in 383 aa overlap); FT Q9XCG5|ACDH from Streptomyces avermitilis (386 aa), FASTA FT scores: opt: 1713, E(): 1.3e-98, (70.0% identity in 383 aa FT overlap); Q9L7W5|FENK from Bacillus subtilis (370 aa), FT FASTA scores: opt: 1094, E(): 2.3e-60, (48.4% identity in FT 372 aa overlap); etc. Contains PS00072 Acyl-CoA FT dehydrogenases signature 1, PS00073 Acyl-CoA dehydrogenases FT signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:O06164" FT /db_xref="HSSP:1JQI" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:O06164" FT /protein_id="CAB08918.1" FT /translation="MTTTTTTISGGILPKEYQDLRDTVADFARTVVAPVSAKHDAEHSF FT PYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLEELGKVDQSVAITLEAAVGLGAM FT PIYRFGTEEQKQKWLPDLTSGRALAGFGLTEPGAGSDAGSTRTTARLEGDEWIINGSKQ FT FITNSGTDITSLVTVTAVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASD FT THPLTFADARVPRENLLGARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVKYANQ FT RQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKPFKKEAAIAKMISSEA FT AMDNSRDATQIHGGYGFMNEYPVARHYRDSKVLEIGEGTTEVQLMLIARSLGLQ" FT misc_feature complement(40769..40828) FT /note="PS00073 Acyl-CoA dehydrogenases signature 2" FT misc_feature complement(41444..41482) FT /note="PS00072 Acyl-CoA dehydrogenases signature 1" FT CDS complement(41880..43844) FT /transl_table=11 FT /gene="accA1" FT /locus_tag="Rv2501c" FT /standard_name="bccA" FT /product="PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE FT ALPHA CHAIN (ALPHA SUBUNIT) ACCA1: BIOTIN CARBOXYLASE + FT BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)" FT /function="THIS PROTEIN CARRIES TWO FUNCTIONS: BIOTIN FT CARBOXYL CARRIER PROTEIN AND BIOTIN CARBOXYLTRANSFERASE. FT INVOLVED IN THE FIRST STEP OF LONG-CHAIN FATTY ACID FT SYNTHESIS [CATALYTIC ACTIVITY: ATP + FT BIOTIN-CARBOXYL-CARRIER PROTEIN + CO(2) = ADP + PHOSPHATE + FT CARBOXYBIOTIN-CARBOXYL-CARRIER PROTEIN]." FT /EC_number="6.3.4.14" FT /note="Rv2501c, (MTCY07A7.07c, P46401), len: 654 aa. FT Probable accA1 (alternate gene name: bccA), FT acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) FT [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN FT CARBOXYL CARRIER PROTEIN (BCCP)], similar to others eg FT Q9L076|FABG from Streptomyces coelicolor (646 aa), FASTA FT scores: opt: 2071, E(): 1e-113, (57.8% identity in 659 aa FT overlap); AAK24139|Q9A6C6|CC2168 from Caulobacter FT crescentus (654 aa), FASTA scores: opt: 1754, E(): 3.7e-95, FT (47.2% identity in 661 aa overlap); etc. Contains PS00188 FT Biotin-requiring enzymes attachment site, PS00866 FT Carbamoyl-phosphate synthase subdomain signature 1, and FT PS00867 Carbamoyl-phosphate synthase subdomain signature FT 2." FT /db_xref="GOA:P0A508" FT /db_xref="HSSP:1BNC" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/Swiss-Prot:P0A508" FT /protein_id="CAB08919.1" FT /translation="MFDTVLVANRGEIAVRVIRTLRRLGIRSVAVYSDPDVDARHVLEA FT DAAVRLGPAPARESYLDIGKVLDAAARTGAQAIHPGYGFLAENADFAAACERARVVFLG FT PPARAIEVMGDKIAAKNAVAAFDVPVVPGVARAGLTDDALVTAAAEVGYPVLIKPSAGG FT GGKGMRLVQDPARLPEALVSARREAMSSFGDDTLFLERFVLRPRHIEVQVLADAHGNVV FT HLGERECSLQRRHQKVIEEAPSPLLDPQTRERIGVAACNTARCVDYVGAGTVEFIVSAQ FT RPDEFFFMEMNTRLQVEHPVTEAITGLDLVEWQLRVGAGEKLGFAQNDIELRGHAIEAR FT VYAEDPAREFLPTGGRVLAVFEPAGPGVRVDSSLLGGTVVGSDYDPLLTKVIAHGADRE FT EALDRLDQALARTAVLGVQTNVEFLRFLLADERVRVGDLDTAVLDERSADFTARPAPDD FT VLAAGGLYRQWALARRAQGDLWAAPSGWRGGGHMAPVRTAMRTPLRSETVSVWGPPESA FT QVQVGDGEIDCASVQVTREQMSVTISGLRRDYRWAEADRHLWIADERGTWHLREAEEHK FT IHRAVGARPAEVVSPMPGSVIAVQVESGSQISAGDVVVVVEAMKMEHSLEAPVSGRVQV FT LVSVGDQVKVEQVLARIKD" FT misc_feature complement(41964..42017) FT /note="PS00188 Biotin-requiring enzymes attachment site" FT misc_feature complement(42960..42983) FT /note="PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2" FT misc_feature complement(43344..43388) FT /note="PS00866 Carbamoyl-phosphate synthase subdomain FT signature 1" FT CDS complement(43849..45438) FT /transl_table=11 FT /gene="accD1" FT /locus_tag="Rv2502c" FT /product="PROBABLE ACETYL-/PROPIONYL-CoA CARBOXYLASE (BETA FT SUBUNIT) ACCD1" FT /function="INVOLVED IN FATTY ACID METABOLISM." FT /EC_number="6.4.1.-" FT /note="Rv2502c, (MTCY07A7.08c), len: 529 aa. Probable FT accD1, acetyl-/propionyl-CoA carboxylase (beta subunit) (EC FT 6.4.1.-), similar, but with N-terminus shorter, to FT Q9L077|ACCD1 from Streptomyces coelicolor (538 aa), FASTA FT scores: opt: 2747, E(): 1.9e-159, (77.9% identity in 516 aa FT overlap). Also similar to others e.g. AAK24141|CC2170 from FT Caulobacter crescentus (530 aa), FASTA scores: opt: 2413, FT E(): 3.8e-139, (69.4% identity in 529 aa overlap); FT BAB54131|MLL7731 from Rhizobium loti (537 aa), FASTA FT scores: opt: 2399, E(): 2.7e-138, (67.4% identity in 527 aa FT overlap); etc. COULD BELONG TO THE ACCD/PCCB FAMILY." FT /db_xref="GOA:O06165" FT /db_xref="HSSP:1ON9" FT /db_xref="InterPro:IPR011763" FT /db_xref="UniProtKB/TrEMBL:O06165" FT /protein_id="CAB08920.1" FT /translation="MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKRHVSR FT GKLLPRERVDRLLDPGSPFLELAPLAAGGMYGDESPGAGIITGIGRVSGRQCVIVANDA FT TVKGGTYYPMTVKKHLRAQEVALQNMLPCIYLVDSGGAFLPRQDEVFPDREHFGRIFYN FT QATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEIVS FT AEELGGGDLHSRTSGVTDHLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEPKYPQA FT ELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKTLVTAFARVHGHPVGIVANNG FT VLFSESALKGAHFIELCDKRKIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMVTAVACAR FT VPKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRGEQLSA FT AGTPWSPDEEEAFKAPIRAQYEDQGNPYYSTARLWDDGIIDPADTRTVVGLALSLCAHA FT PLDQVGYGVFRM" FT CDS complement(45435..46091) FT /transl_table=11 FT /gene="scoB" FT /locus_tag="Rv2503c" FT /product="PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A FT TRANSFERASE (BETA SUBUNIT) SCOB (3-OXO-ACID:COA FT TRANSFERASE) (OXCT B) (SUCCINYL CoA:3-OXOACID FT CoA-TRANSFERASE)" FT /function="INVOLVED IN VARIOUS DEGRADATION AND SYNTHESIS FT [CATALYTIC ACTIVITY: SUCCINYL-CoA + A 3-OXO ACID = FT SUCCINATE + A 3-OXO-ACYL-COA]." FT /EC_number="2.8.3.5" FT /note="Rv2503c, (MTCY07A7.09c, MT2578), len: 218 aa. FT Probable scoB, 3-oxo acid:CoA transferase, beta subunit FT (succinyl-CoA:3-ketoacid-CoA transferase) (EC 2.8.3.5). FT Highly similar to others e.g. Q9XAM8|SC4C6.12c from FT Streptomyces coelicolor (217 aa), FASTA scores: opt: 1048, FT E(): 2.6e-60, (73.9% identity in 207 aa overlap); FT Q9XD82|PCAJ from Streptomyces sp. 2065 (214 aa), FASTA FT scores: opt: 1031, E(): 3.2e-59, (70.8% identity in 209 aa FT overlap); AAK53493|LPSJ from Xanthomonas campestris (pv. FT campestris) (212 aa), FASTA scores: opt: 886, E(): 6.6e-50, FT (62.5% identity in 208 aa overlap); P42316|SCOB_BACSU from FT Bacillus subtilis (216 aa), FASTA scores: opt: 820, E(): FT 1.2e-45, (58.2% identity in 201 aa overlap); etc. BELONGS FT TO THE 3-OXOACID COA-TRANSFERASE SUBUNIT B FAMILY." FT /db_xref="GOA:P63650" FT /db_xref="HSSP:1O9L" FT /db_xref="InterPro:IPR004164" FT /db_xref="UniProtKB/Swiss-Prot:P63650" FT /protein_id="CAB08921.1" FT /translation="MSAPGWSRDEMAARVAAEFEDGQYVNLGIGMPTLIPNHIPDGVHV FT VLHSENGILGVGPYPRREDVDADLINAGKETVTTLPGAAFFSSSTSFGIIRGGHLDVAV FT LGAMQVSVTGDLANWMIPGKMVKGMGGAMDLVHGARKVIVMMEHTAKDGSPKILERCTL FT PLTGVGCVDRIVTELAVIDVCADGLHLVQTAPGVSVDEVVAKTQPPLVLRDLATQ" FT CDS complement(46088..46834) FT /transl_table=11 FT /gene="scoA" FT /locus_tag="Rv2504c" FT /product="PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A FT TRANSFERASE (ALPHA SUBUNIT) SCOA (3-OXO ACID:CoA FT TRANSFERASE) (OXCT A) (SUCCINYL-COA:3-OXOACID-COENZYME A FT TRANSFERASE)" FT /function="INVOLVED IN FATTY ACID DEGRADATION/SYNTHESIS FT [CATALYTIC ACTIVITY: SUCCINYL-CoA + A 3-OXO ACID = FT SUCCINATE + A 3-OXO-ACYL-COA]." FT /EC_number="2.8.3.6" FT /note="Rv2504c, (MT2579, MTCY07A7.10c), len: 248 aa. FT Probable scoA, succinyl-CoA:3-ketoacid-Coenzyme A FT transferase, alpha subunit (3-oxo acid:CoA transferase) (EC FT 2.8.3.6). Highly similar to others e.g. Q9XAM7|SC4C6.13c FT from Streptomyces coelicolor (260 aa), FASTA scores: opt: FT 1130, E(): 2.2e-64, (69.9% identity in 249 aa overlap); FT Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA FT scores: opt: 1121, E(): 8.1e-64, (69.5% identity in 249 aa FT overlap); etc. BELONGS TO THE 3-OXOACID COA-TRANSFERASE FT SUBUNIT A FAMILY." FT /db_xref="GOA:P63648" FT /db_xref="HSSP:1M3E" FT /db_xref="InterPro:IPR004163" FT /db_xref="UniProtKB/Swiss-Prot:P63648" FT /protein_id="CAB08922.1" FT /translation="MDKVVATAAEAVADIANGSSLAVGGFGLCGIPEALIAALVDSGVT FT DLETVSNNCGIDGVGLGLLLQHKRIRRTVSSYVGENKEFARQFLAGELEVELTPQGTLA FT ERLRAGGMGIPAFYTPAGVGTQVADGGLPWRYDASGGVAVVSPAKETREFDGVTYVLER FT GIRTDFALVHAWQGDRHGNLMYRHAAANFNPECASAGRITIAEVEHLVEPGEIDPATVH FT TPGVFVHRVVHVPNPAKKIERETVRQ" FT CDS complement(46917..48560) FT /transl_table=11 FT /gene="fadD35" FT /locus_tag="Rv2505c" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD35 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv2505c, (MTCY07A7.11c), len: 547 aa. Probable FT fadD35, fatty-acid-CoA synthetase (EC 6.2.1.-), highly FT similar to many e.g. Q9Z5A6|SC2G5.17 from Streptomyces FT coelicolor (541 aa), FASTA scores: opt: 2202, E(): 8e-131, FT (61.55% identity in 528 aa overlap); Q9F9U4|FADD from FT Pseudomonas stutzeri (Pseudomonas perfectomarina), FASTA FT scores: opt: 1551, E(): 7.3e-90, (55.55% identity in 551 aa FT overlap); Q987S7|MLR6932 from Rhizobium loti (Mesorhizobium FT loti) (590 aa), FASTA scores: opt: 1453, E(): 1.1e-83, FT (50.7% identity in 564 aa overlap); etc." FT /db_xref="GOA:O06168" FT /db_xref="HSSP:1BA3" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:O06168" FT /protein_id="CAB08923.1" FT /translation="MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREAL FT VDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQYATAEIGAI FT LVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAEVGPRCPDLADVILLESD FT RWDALAGAEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGE FT LLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTS FT LYGVPTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMT FT ETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCTRGYSVMA FT GYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELL FT HTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLW FT IVDEFPMTVTGKVRKVEMRQQALEYLRGQQ" FT CDS 48676..49323 FT /transl_table=11 FT /locus_tag="Rv2506" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv2506, (MTCY07A7.12), len: 215 aa. Probable FT transcriptional regulator, tetR family, similar to many FT others e.g. Q9L078|SCC105.06c PUTATIVE TETR-FAMILY FT REGULATORY PROTEIN from Streptomyces coelicolor (208 aa), FT FASTA scores: opt: 333, E(): 1.5e-14, (48.75% identity in FT 197 aa overlap); Q9X7X6|SC6A5.30c PUTATIVE REGULATORY FT PROTEIN from Streptomyces coelicolor (404 aa), FASTA FT scores: opt: 267, E(): 4.8e-10, (30.45% identity in 207 aa FT overlap) (similarity only with C-terminus for this one); FT Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL FT REGULATOR from Streptomyces coelicolor (213 aa), FASTA FT scores: opt: 239, E(): 1.8e-08, (29.9% identity in 184 aa FT overlap); etc. Also similar to transcriptional regulatory FT proteins from Mycobacterium tuberculosis e.g. FT O05858|Rv3208|MTCY07D11.18c (228 aa), FASTA scores: opt: FT 218, E(): 4.4e-07, (30.35% identity in 191 aa overlap); FT C-terminus of P95251|Rv1963c|MTV051.01c|MTCY09F9.01 (406 FT aa), FASTA scores: opt: 238, E(): 3.6e-08, (28.25% identity FT in 177 aa overlap); P96839|Rv3557c|MTCY06G11.04c (200 aa), FT FASTA scores: opt: 215, E(): 6.2e-07, (38.25% identity in FT 148 aa overlap); etc. Equivalent to AAK46885 from FT Mycobacterium tuberculosis strain CDC1551 (231 aa) but FT shorter 16 aa. Contains probable helix-turn-helix motif at FT aa 46-67, (Score 1660, +4.84 SD). BELONGS TO THE TETR/ACRR FT FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:O06169" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:O06169" FT /protein_id="CAB08924.1" FT /translation="MTASAPDGRPGQPEATNRRSQLKSDRRFQLLAAAERLFAERGFLA FT VRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVGVSARLLAGARDVTTRSANLAAALDG FT LIEFHLDFALGEADLIRIQDRDLAHLPAVAERQVRKAQRQYVEVWVGVLRELNPGLAEA FT DARLMAHAVFGLLNSTPHSMKAADSKPARTVRARAVLRAMTVAALSAADRCL" FT CDS 49402..50223 FT /transl_table=11 FT /locus_tag="Rv2507" FT /product="POSSIBLE CONSERVED PROLINE RICH MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2507, (MTCY07A7.13), len: 273 aa. Possible FT conserved pro-rich membrane protein (N-terminal half is FT Proline-rich), highly similar to Q9CCU3|ML0431 PUTATIVE FT MEMBRANE PROTEIN from Mycobacterium leprae (259 aa) (alias FT O07711|MLCL383.38c but longer 2 aa), FASTA scores: opt: FT 968, E(): 1.4e-31, (60.35% identity in 275 aa overlap). FT Contains potential membrane spanning region." FT /db_xref="UniProtKB/TrEMBL:O06170" FT /protein_id="CAB08925.1" FT /translation="MNDPRRPQRFGPPLSGYGPTGPQVPPNPPTADPAYADQSPYASTY FT GGYVSPPWSPGGPPPRPPQWPPGPHEASPTQQLPQYWQYDQPPPGGFPPDGLTPPPPQG FT PRTPRWLWFAAGSAVLLVVALVIALVIANGSVKKQTAIEPLPPMPGPSPTRPTTTTPTP FT PSPSAAPAPTTTTGTPSETVAGAMQTVVYDVTGEGRAISITYMDSGNVIQTEFNVALPW FT RKEVSLSKSSLHPASVTIVNIGHNVTCSVTVAGVQVRQRTGAGLTICDAPS" FT CDS complement(50220..51557) FT /transl_table=11 FT /locus_tag="Rv2508c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE LEUCINE AND FT ALANINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2508c, (MTCY07A7.14c), len: 445 aa. Probable FT conserved integral membrane leu-, ala-rich protein, FT equivalent to Q9CCU4|ML0430 PUTATIVE MEMBRANE PROTEIN from FT Mycobacterium leprae (454 aa) (alias O07710|MLCL383.37 FT longer 10 aa), FASTA scores: opt: 2205, E(): 2.5e-124, FT (75.75% identity in 441 aa overlap). Also similar to FT hypothetical or membrane proteins e.g. BAB50841|MLL4103 FT HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium FT loti) (458 aa), FASTA scores: opt: 396, E(): 2.4e-16, FT (27.75% identity in 447 aa overlap); Q9RKX9|SC6D7.19c FT PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces FT coelicolor (486 aa), FASTA scores: opt: 323, E(): 5.7e-12, FT (28.95% identity in 428 aa overlap); P42306|YXIO_BACSU FT PROBABLE INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis FT (428 aa), FASTA scores: opt: 220, E(): 7.2e-06, (20.35% FT identity in 413 aa overlap); etc. Also similar to proteins FT from Mycobacterium tuberculosis e.g. FT Q10564|Y876_MYCTU|Rv0876c|MT0899|MTCY31.04c (548 aa), FASTA FT scores: opt: 184, E(): 0.0012, (24.7% identity in 466 aa FT overlap)." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:O06171" FT /protein_id="CAB08926.1" FT /translation="MNNPGSRAGTLLHFRVVAWAMWDCGSTGLNAIVTTFVFSVYLTSA FT VGQGLPGGTSPASWLGRAGAVAGLTIGVLAPVVGVWVESPHRRRVALSVLTGTAVALTC FT AMFLIRDDPRYLWAGLVLLAATAASSDLSSVPYNAMLRQLSTPSTAGRISGFGWASGYV FT GSVALLLVIYLGFMSGSGSQRGLLQLPVANGLNVRMAMLVAAAWLALLGLPLLLVAHRL FT PDSGAASHPSTGLLGGYRKLWTEISAEWRRDRNLVYFLVASAIFRDGLAAIFAFGAVLG FT VNAYGLTQADVLIFGAAASVVAAVGAVLGGFVDHRIGSKPVIVGSLAAIIAAALTLLTL FT SGPTAFWACGLLLCVFIGPAQSSARALLLHMAQHGKEGVAFGLYTMTGRAVSFLGPWLF FT SVFVDVFHTVRAGLGGVCLVLTTGLLLMLRVQVSRHGGALTTAQSS" FT CDS 51642..52448 FT /transl_table=11 FT /locus_tag="Rv2509" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv2509, (MTCY07A7.15), len: 268 aa. Probable FT ala-rich oxidoreductase, short-chain FT dehydrogenase/reductase (EC 1.-.-.-), equivalent to FT O07709|MLCL383.36c|ML0429 DEHYDROGENASE (PUTATIVE FT OXIDOREDUCTASE) from Mycobacterium leprae (268 aa), FASTA FT scores: opt: 1509, E(): 2.6e-84, (88.75% identity in 267 aa FT overlap). Also highly similar to others e.g. FT O86553|SC1F2.16c PUTATIVE DEHYDROGENASE from Streptomyces FT coelicolor (276 aa), FASTA scores: opt: 492, E(): 9.5e-23, FT (38.15% identity in 262 aa overlap); Q9I5R3|PA0658 PROBABLE FT SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (266 FT aa), FASTA scores: opt: 472, E(): 1.5e-21, (37.8% identity FT in 246 aa overlap); AAK22120|CC0133 OXIDOREDUCTASE FT (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from FT Caulobacter crescentus (266 aa), FASTA scores: opt: 428, FT E(): 6.9e-19, (35.8% identity in 243 aa overlap); etc. Also FT highly similar or similar to oxidoreductases from FT Mycobacterium tuberculosis e.g. Q10782|Rv1544|MTCY48.21 FT PUTATIVE KETOACYL REDUCTASE (EC 1.3.1.-) (267 aa), FASTA FT scores: opt: 656, E(): 1.1e-32, (43.05% identity in 267 aa FT overlap). Contains PS00061 Short-chain alcohol FT dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:O06172" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O06172" FT /protein_id="CAB08927.1" FT /translation="MPIPAPSPDARAVVTGASQNIGAALATELAARGHHLIVTARREDV FT LTELAARLADKYRVTVDVRPADLADPQERSKLADELAARPISILCANAGTATFGPIASL FT DLAGEKTQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAGNSPIPYNATYAATKAF FT VNTFSESLRGELRGSGVHVTVLAPGPVRTELPDASEASLVEKLVPDFLWISTEHTARVS FT LNALERNKMRVVPGLTSKAMSVASQYAPRAIVAPIVGAFYKRLGGS" FT misc_feature 52071..52157 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS complement(52452..54053) FT /transl_table=11 FT /locus_tag="Rv2510c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2510c, (MTCY07A7.16c), len: 533 aa. Hypothetical FT unknown protein, highly similar, but longer approximatively FT 20 aa, to others e.g. Q9ABY0|CC0090 HYPOTHETICAL PROTEIN FT from Caulobacter crescentus (516 aa), FASTA scores: opt: FT 1282, E(): 8.4e-63, (45.1% identity in 490 aa overlap); FT Q9A130|SPY0500 HYPOTHETICAL PROTEIN from Streptococcus FT pyogenes (500 aa), FASTA scores: opt: 1281, E(): 9.3e-63, FT (43.8% identity in 491 aa overlap); Q985L5|MLR7622 FT HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium FT loti) (515 aa), FASTA scores: opt: 1259, E(): 1.5e-61, FT (44.1% identity in 510 aa overlap); P39342|YJGR_ECOLI|B4263 FT HYPOTHETICAL 54.3 KDA PROTEIN from Escherichia coli strain FT K12 (500 aa), FASTA scores: opt: 1257, E(): 1.9e-61, (42.7% FT identity in 501 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="InterPro:IPR008571" FT /db_xref="UniProtKB/TrEMBL:O06173" FT /protein_id="CAB08911.1" FT /translation="MGTESAAGGPGGPAQRIAAGYTVEGQALQLGTVVVDGEPDPSAQI FT RIPLATVNRHGLVAGATGTGKTKTLQLIAEQLSAAGVAVLMADVKGDLSGLARPGEAAD FT KTAARAKDTGDDWVPTAFPVEFLSLGASGVGVPVRATISSFGPILLAKVLGLNATQEST FT LGLIFHWADQRGLPLLDLKDLRAVITHLTSDEGKVELKSLGAVSPTTAGVILRALVNLE FT AEGADTFFGEPELRPEDLLRVDSQGRGIISLLEFGSQALRPAMFSTFLMWVLADLFTFL FT PEVGDLDKPKLVFFFDEAHLLFTDASKAFLEQVEQTVKLIRSKGVGVFFCTQLPTDLPN FT DVLSQLGARIQHALRAFTPDDHKALRKTVRTYPKTDVYDLESALTSLGTGEAVVTVLSE FT KGAPTPVAWTRMRAPRSLMAAIGAEAIGAAAQASSLQAVYGQTIDRPSAHEILSAKLAP FT AQEAPAQEAPAPRGQYDPLPWPDDFEVPPMPAPVEPQGPAVWEEILKNPTVKSVLNTTA FT REITRSIFGTGRRRRK" FT misc_feature complement(53853..53876) FT /note="PS00017 ATP/GTP-binding site motif A." FT CDS 54121..54768 FT /transl_table=11 FT /gene="orn" FT /locus_tag="Rv2511" FT /product="OLIGORIBONUCLEASE ORN" FT /function="INVOLVED IN RNA DEGRADATION: 3'-TO-5' FT EXORIBONUCLEASE SPECIFIC FOR SMALL OLIGORIBONUCLEOTIDES." FT /EC_number="3.1.-.-" FT /note="Rv2511, (MTCY07A7.17), len: 215 aa. orn, FT oligoribonuclease (EC 3.1.-.-), equivalent to FT O07708|ORN_MYCLE|ORN|ML0427|MLCL383.34c OLIGORIBONUCLEASE FT from Mycobacterium leprae (215 aa), FASTA scores: opt: FT 1170, E(): 3.5e-65, (84.5% identity in 213 aa overlap). FT Also highly similar to many e.g. P57667|ORN_STRGR|ORNA from FT Streptomyces griseus (201 aa), FASTA scores: opt: 807, E(): FT 7.7e-43, (59.0% identity in 200 aa overlap); FT ORN_STRCO|ORNA|2SC13.01 from Streptomyces coelicolor (200 FT aa), FASTA scores: opt: 799, E(): 2.4e-42, (59.7% identity FT in 201 aa overlap); P39287|ORN_ECOLI|B4162 from Escherichia FT coli strain K12 (180 aa), FASTA scores: opt: 519, E(): FT 3.9e-25, (47.4% identity in 173 aa overlap); etc. BELONGS FT TO THE OLIGORIBONUCLEASE FAMILY." FT /db_xref="GOA:P65597" FT /db_xref="HSSP:1J9A" FT /db_xref="InterPro:IPR006055" FT /db_xref="UniProtKB/Swiss-Prot:P65597" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08931.1" FT /translation="MQDELVWIDCEMTGLDLGSDKLIEIAALVTDADLNILGDGVDVVM FT HADDAALSGMIDVVAEMHSRSGLIDEVKASTVDLATAEAMVLDYINEHVKQPKTAPLAG FT NSIATDRAFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPPKGLTHRALADI FT HESIRELRFYRRTAFVPQPGPSTSEIAAVVAELSDGAGAQEETDSAEAPQSG" FT tRNA 54818..54890 FT /gene="tRNA-His(GTG)" FT /product="transfer RNA-His(GTG)" FT /anticodon=(pos:54851..54853,aa:His) FT repeat_region complement(55453..56902) FT /mobile_element="insertion sequence:IS1081-3" FT /note="IS1081-3, len: 1450 bp. Insertion sequence IS1081." FT CDS complement(55520..56767) FT /transl_table=11 FT /locus_tag="Rv2512c" FT /product="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT FT IS1081" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1081." FT /note="Rv2512c, (MTCY07A7.18c), len: 415 aa. Transposase FT for IS1081, identical to P35882|TRA1_MYCBO transposase for FT insertion sequence element IS1081 from Mycobacterium bovis FT (415 aa), FASTA scores: opt: 2680, E(): 1.9e-162, (100.0% FT identity in 415 aa overlap). Also highly similar to others FT from Mycobacterium tuberculosis e.g. FT P96354|Rv1047|MTCY10G2.02c|Rv3115|MTCY164.25|Rv3023c|MTV0 FT 12 .38c (415 aa), FASTA scores: opt: 2675, E(): 3.9e-162, FT (99.75% identity in 415 aa overlap). Contains PS00435 FT Peroxidases proximal heme-ligand signature, PS01007 FT Transposases, Mutator family, signature. BELONGS TO THE FT MUTATOR FAMILY OF TRANSPOSASE." FT /db_xref="GOA:P60230" FT /db_xref="InterPro:IPR001207" FT /db_xref="UniProtKB/Swiss-Prot:P60230" FT /protein_id="CAB08912.1" FT /translation="MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALC FT GAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALT FT SVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTF FT LAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVAR FT GLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSI FT YDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIWSNNPQE FT RLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTST FT EEPAKQQTTNTPALTT" FT misc_feature complement(55997..56071) FT /note="PS01007 Transposases, Mutator family, signature" FT misc_feature complement(56213..56245) FT /note="PS00435 Peroxidases proximal heme-ligand signature" FT CDS 57125..57547 FT /transl_table=11 FT /locus_tag="Rv2513" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2513, (MTCY07A7.19), len: 140 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O06175" FT /protein_id="CAB08913.1" FT /translation="MDDIAAFKLDSLPDITFTVTRAISSGGENPAGFLNFAARREQPEI FT LGGGGRPGPVGPEAVDTPRIRGGKVPFVFRTLPGYTFYASQIEPRVGDPEGPTLLAGFG FT NIPETSQRSPGWIRITCTGPDDDEELEFFGFAGPES" FT CDS complement(57841..58302) FT /transl_table=11 FT /locus_tag="Rv2514c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2514c, (MTCY07A7.20c), len: 153 aa. Conserved FT hypothetical protein, showing some similarity to FT Q9PG05|XF0497 HYPOTHETICAL PROTEIN from Xylella fastidiosa FT (155 aa), FASTA scores: opt: 215, E(): 1.4e-07, (30.6% FT identity in 160 aa overlap)." FT /db_xref="InterPro:IPR016541" FT /db_xref="UniProtKB/TrEMBL:O06176" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08914.1" FT /translation="MLYSFDTSAILNGRRDLFRPAVFRSLWGRVEDAISAGQIRSVDEV FT QRELARRDDDAKRWADGQTGLFCPLDEQIQQAARHILRLHPNMVRQGGRRSAADPFVIA FT LAMVNNATVVTQETASGNIEKPRIPDVCDALGVPWLTLMGYIEAQGWTF" FT CDS complement(58308..59555) FT /transl_table=11 FT /locus_tag="Rv2515c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2515c, (MTCY07A7.21c), len: 415 aa. Conserved FT hypothetical protein, showing some similarity to FT Q9PG06|XF0496 HYPOTHETICAL PROTEIN from Xylella fastidiosa FT (391 aa), FASTA scores: opt: 388, E(): 4.4e-18, (27.8% FT identity in 399 aa overlap). Contains PS00142 Neutral zinc FT metallopeptidases, zinc-binding region signature." FT /db_xref="GOA:O06177" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:O06177" FT /protein_id="CAB08915.1" FT /translation="MGIGHPMWVGWCIIIAMRSIPASVESSVLRWARESCGLTEVAAAR FT KLGLPDDRVAAWEVGEVVPTIAQLRKAAEVYKRSLAVFFLSEPPEGFDTLRDFRRLDGA FT ASGQWTPGLHEEFRRAHTQRDFALELADAEDREIPGAWRLPLSGDEADADIAARIRKAL FT IEVSPLPIPVASVDPYEHLNAWVSAIETSGVLVLATRGGKVAIDEMRGMCLYFDELPVI FT VLNGSDHPRPRLFSLLHEFVHVVLHTEGLCDVIADAHPSTQDRSLEARCNAIAAAVLMP FT ADVVRARPEVIVRSETPSSWDYESLRPVAAHFGVSAEAFLRRLSTLGIVPVEVYRQRRA FT EFIAAHEDEAERARSAGGGNWYRNTVRDLGKGYVRAVTDAHRRRVIDSNTAAIYLDAKV FT SQIPKLAESAELRSVV" FT misc_feature complement(58821..58850) FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS complement(59674..60477) FT /transl_table=11 FT /locus_tag="Rv2516c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2516c, (MTV009.01c), len: 267 aa. Hypothetical FT unknown protein. Contains probable helix-turn-helix motif FT at aa 98 to 119 (Score 1743, +5.12 SD). C-terminus extended FT since first submission (+ 18 aa). TBparse score is 0.964." FT /db_xref="UniProtKB/TrEMBL:O53221" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16012.2" FT /translation="MTADWVVTFTFDADPSMETMDAWETQLEGFDALVSRVPGHGIDVT FT VYAPGDWSVFDALAKMAGEVMPVVQAKSPIAVQIISEPEHRLRAEAFTTPELMSAAEIA FT DELGVSRQRVHQLRSTAGFPAPLADLRGGAVWDAAAVRRFAETWERKPGRPHTGTAKFA FT YSWAVGPAVGRSGKAPNVRWRVENPDKIRFVLRNIGDDIAEDVEIDLSRIDAITRNVPK FT KTVIRPGEGLNMVLIAAWGHPLPNQLYVRWAGQDEWAAVPLHPAH" FT CDS complement(60474..60725) FT /transl_table=11 FT /locus_tag="Rv2517c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2517c, (MTV009.02c), len: 83 aa. Hypothetical FT unknown protein. Equivalent to AAK46899 from Mycobacterium FT tuberculosis strain CDC1551 (97 aa) but shorter 14 aa. FT Questionable orf." FT /db_xref="UniProtKB/TrEMBL:O53222" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16013.1" FT /translation="MNSAIIKIAKWAQSQQWTVEDDASGYTRFYNPQGVYIARFPATPS FT NEYRRMRDLLGALKKAGLTWPPPSKKERRAQHRKEGAQ" FT CDS complement(61073..62299) FT /transl_table=11 FT /gene="lppS" FT /locus_tag="Rv2518c" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPPS" FT /function="UNKNOWN" FT /note="Rv2518c, (MTV009.03c), len: 408 aa. Probable lppS, FT conserved lipoprotein, highly similar to O07707|MLCL383.3 FT HYPOTHETICAL 43.6 KDA PROTEIN from Mycobacterium leprae FT (407 aa), FASTA scores: opt: 2300, E(): 1.2e-130, (82.5% FT identity in 406 aa overlap); Q9CCU5|LPPS|ML0426 PUTATIVE FT SECRETED PROTEIN from Mycobacterium leprae (404 aa), FASTA FT scores: opt: 2279, E(): 2.3e-129, (82.4% identity in 403 aa FT overlap); and Q9CB49|ML2446 POSSIBLE LIPOPROTEIN from FT Mycobacterium leprae (441 aa), FASTA scores: opt: 736, E(): FT 8.4e-37, (35.6% identity in 399 aa overlap). Also similar FT to other proteins from several organisms e.g. FT Q9X811|SC6G10.26c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (424 aa), FASTA scores: opt: 867, FT E(): 1.1e-44, (32.25% identity in 403 aa overlap); FT Q9L1E8|SC3D11.14 PUTATIVE LIPOPROTEIN from Streptomyces FT coelicolor (416 aa), FASTA scores: opt: 737, E(): 7e-37, FT (32.95% identity in 413 aa overlap); Q9KYV1|SCE22.11 FT PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (407 aa), FT FASTA scores: opt: 721, E(): 6.2e-36, (33.5% identity in FT 400 aa overlap). And similar to several hypothetical FT mycobacterial proteins e.g. FT Q11149|Y483_MYCTU|Rv0483|MT0501|MTCY20G9.09 (451 aa), FASTA FT scores: opt: 763, E(): 2.1e-38, (34.85% identity in 402 aa FT overlap). Has very long signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site. TBparse score is 0.881." FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:O53223" FT /protein_id="CAA16014.1" FT /translation="MPKVGIAAQAGRTRVRRAWLTALMMTAVMIGAVACGSGRGPAPIK FT VIADKGTPFADLLVPKLTASVTDGAVGVTVDAPVSVTAADGVLAAVTMVNDNGRPVAGR FT LSPDGLRWSTTEQLGYNRRYTLNATALGLGGAATRQLTFQTSSPAHLTMPYVMPGDGEV FT VGVGEPVAIRFDENIADRGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGTAV FT DVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDNTKILTVRVNGEVVKSMPTSMG FT KDSTPTANGIYIVGSRYKHIIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPW FT SVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNTVGGTLPGIDGLGDWNIPWD FT QWRAGNAKA" FT misc_feature complement(62195..62227) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT tRNA 62458..62530 FT /gene="tRNA-Lys(CTT)" FT /product="transfer RNA-Lys(CTT)" FT /anticodon=(pos:62491..62493,aa:Lys) FT CDS 62749..64227 FT /transl_table=11 FT /gene="PE26" FT /locus_tag="Rv2519" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2519, (MTV009.04), len: 492 aa. Member of the M. FT tuberculosis PE family (see citation below), highly similar FT to many e.g. Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c FT (543 aa), FASTA scores: opt: 848, E(): 3e-30, (39.55% FT identity in 445 aa overlap). TBparse score is 0.91." FT /db_xref="GOA:Q79FD3" FT /db_xref="InterPro:IPR001969" FT /db_xref="UniProtKB/TrEMBL:Q79FD3" FT /protein_id="CAE55497.1" FT /translation="MSRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTTLLVAAAED FT EVSAAAAALFANYGREYQTLSVRFASLDQQFAQALNSAAASYQTAEATGASLVQTATQG FT VLGVINAPTEFMFGRSLIGDGADGTAASPIGEPGGILYGDGGNGYSQTTPGAVGGAGGS FT AGFIGNGGAGGAGGPGAGGGTGGLGGWLWGNNGAAGTGDPVNVAVPLRVENNFPLVNLL FT VNRGPTVPILLDTGSSSLVIPFWKIGWQNLGLPTGFDVVHYGNGVSIVYADVPTTVDFG FT GGAATTPTSVHVGILPYPRNLDSLVLIASGGAFGPNGNGILGIGPNVGSYAVSGPGNVV FT TTDLPGQLNEGTLIDIPGGYMQFGPNTGTPITSVTGAPITVLNVQIGGYDPNGGYWSLP FT SIFDSGGNHGTLPAVILGTGQTTGYAPPGTVISISIHDNQTLLYQYTTTASNSPVVTAD FT PRLNTGLTPFLLGPVYISNNPSGVGTVVFNYPPP" FT CDS complement(64352..64579) FT /transl_table=11 FT /locus_tag="Rv2520c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2520c, (MTV009.05c), len: 75 aa. Possible FT conserved membrane protein, equivalent to O07706|MLCL383.32 FT HYPOTHETICAL 10.0 KDA PROTEIN from Mycobacterium leprae (91 FT aa), FASTA scores: opt: 290, E(): 4.1e-14, (58.65% identity FT in 75 aa overlap); and Q9CCU6|ML0425 PUTATIVE MEMBRANE FT PROTEIN from Mycobacterium leprae (75 aa), FASTA scores: FT opt: 286, E(): 6.6e-14, (57.35% identity in 75 aa overlap). FT TBparse score is 0.882." FT /db_xref="UniProtKB/TrEMBL:O53225" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16016.1" FT /translation="MVDRDPNTIKQEIDQTRDQLAATIDSLAERANPRRLADDAKTRVI FT AFLRKPIVTVSLVGIGSVVVVVVIHKIRNR" FT CDS 64648..65121 FT /transl_table=11 FT /gene="bcp" FT /locus_tag="Rv2521" FT /product="PROBABLE BACTERIOFERRITIN COMIGRATORY PROTEIN FT BCP" FT /function="PUTATIVE ANTIOXIDANT PROTEIN." FT /note="Rv2521, (MTV009.06), len: 157 aa. Probable bcp, FT bacterioferritin comigratory protein, equivalent to FT O07705|BCP|ML0424 from Mycobacterium leprae (161 aa), FASTA FT scores: opt: 829, E(): 6.8e-46, (79.6% identity in 157 aa FT overlap). Also highly similar to Q9KZQ2|SCE6.38 FT HYPOTHETICAL 16.8 KDA PROTEIN Streptomyces coelicolor (155 FT aa), FASTA scores: opt: 727, E(): 2e-39, (69.5% identity in FT 154 aa overlap); FT P23480|AAG57590|BCP_ECOLI|B2480|BAB36765|Z3739|ECS3342 FT BACTERIOFERRITIN COMIGRATORY PROTEIN from Escherichia coli FT strain K12 (156 aa), FASTA scores: opt: 513, E(): 8.3e-26, FT (48.3% identity in 149 aa overlap); Q9RW23|DR0846 FT BACTERIOFERRITIN COMIGRATORY PROTEIN from Deinococcus FT radiodurans (175 aa), FASTA scores: opt: 465, E(): 1e-22, FT (46.5% identity in 157 aa overlap); P44411|BCP_HAEIN|HI0254 FT BACTERIOFERRITIN COMIGRATORY PROTEIN from Haemophilus FT influenzae (155 aa), FASTA scores: opt: 453, E(): 5.3e-22, FT (47.5% identity in 139 aa overlap); etc. Also similar to FT Mycobacterium tuberculosis Rv1608c|MTV046.06|bcpB and FT Rv2238c|MTCY427.19c|hpE. TBparse score is 0.897." FT /db_xref="GOA:O53226" FT /db_xref="InterPro:IPR017936" FT /db_xref="UniProtKB/TrEMBL:O53226" FT /protein_id="CAA16017.1" FT /translation="MTKTTRLTPGDKAPAFTLPDADGNNVSLADYRGRRVIVYFYPAAS FT TPGCTKQACDFRDNLGDFTTAGLNVVGISPDKPEKLATFRDAQGLTFPLLSDPDREVLT FT AWGAYGEKQMYGKTVQGVIRSTFVVDEDGKIVVAQYNVKATGHVAKLRRDLSV" FT CDS complement(65093..66505) FT /transl_table=11 FT /locus_tag="Rv2522c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2522c, (MTV009.07c), len: 470 aa. Conserved FT hypothetical protein, equivalent, but longer 20 aa, to FT Q9X7E4|ML1193|MLCB458.08 from HYPOTHETICAL 46.6 KDA PROTEIN FT Mycobacterium leprae (442 aa), FASTA scores: opt: 2521, FT E(): 4.1e-142, (86.35% identity in 440 aa overlap). Also FT similar to various proteins e.g. Q9K425|SCG22.20 PUTATIVE FT PEPTIDASE from Streptomyces coelicolor (451 aa), FASTA FT scores: opt: 1097, E(): 1.1e-57, (42.5% identity in 451 aa FT overlap); Q9FCK3|2SC3B6.09 PUTATIVE PEPTIDASE from FT Streptomyces coelicolor (470 aa), FASTA scores: opt: 669, FT E(): 2.8e-32, (34.2% identity in 462 aa overlap); FT Q98AF9|MLL6018 HYPOTHETICAL PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (486 aa), FASTA scores: opt: 622, E(): FT 1.7e-29, (33.95% identity in 442 aa overlap); Q9RSU7|DR2025 FT ARGE/DAPE/ACY1 FAMILY PROTEIN from Deinococcus radiodurans FT (459 aa), FASTA scores: opt: 616, E(): 3.7e-29, (34.15% FT identity in 442 aa overlap); etc (include some similarity FT to hypothetical proteins from C. elegans and yeast). FT Alternative start possible at 6687 but then no RBS obvious. FT TBparse score is 0.899." FT /db_xref="GOA:O53227" FT /db_xref="InterPro:IPR011650" FT /db_xref="UniProtKB/TrEMBL:O53227" FT /protein_id="CAA16018.1" FT /translation="MSASRRRIASKSGFSCDSASARELVERVREVLPSVRCDLEELVRI FT ESVWADPDRRDEVHRSARAVADLLSQAGFDDVRIVSERGAPAVIARYPAPPGAPTVLLY FT AHHDVQPEGDRGQWVSPPFEPTERGGRLYGRGTADDKAGIATHVAAFWAHGGRPPVGVT FT VFVEGEEESGSPSLGRLLAAHRDALAADVIVIADSDNWSTDIPALTVSLRGMADCVVEV FT ATLDHGLHSGLWGGVVPDALTVLVRLLASLHDDDGNVAVAGMHESTAARVDYPAGRVRA FT ESGLLDGVSEIGTGSVPQRLWAKPAITVIGIDTTSVAAASNTLIPRARAKISIRVAPGG FT DATAHLDAVEAHLRRHAPWGAQVTVTRGEVGQPYAIEASGPVYDAARSAFRQAWGADPI FT DMGMGGSIPFIAEFAAAFPQATILVTGVEDPGTQAHSVNESLHLGVLERAATAEALLLA FT KLAAIPTGRAEA" FT CDS complement(66502..66894) FT /transl_table=11 FT /gene="acpS" FT /locus_tag="Rv2523c" FT /product="HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS FT (HOLO-ACP SYNTHASE) FT (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) FT (CoA:APO-[ACYL-CARRIER FT PROTEIN]PANTETHEINEPHOSPHOTRANSFERASE)" FT /function="BIOSYNTHESIS OF FATTY ACIDS AND LIPIDS. FT TRANSFERS THE 4'-PHOSPHOPANTETHEINE MOIETY FROM COENZYME A FT TO A SER OF ACYL-CARRIER PROTEIN. CATALYZES THE FORMATION FT OF HOLO-ACP, WHICH MEDIATES THE TRANSFER OF ACYL FATTY-ACID FT INTERMEDIATES DURING THE BIOSYNTHESIS OF FATTY ACIDS AND FT LIPIDS [CATALYTIC ACTIVITY: CoA + APO-[ACYL-CARRIER FT PROTEIN] = ADENOSINE 3',5'-BISPHOSPHATE + FT HOLO-[ACYL-CARRIER PROTEIN] ]." FT /EC_number="2.7.8.7" FT /note="Rv2523c, (MT2599, MTV009.08c), len: 130 aa. acpS, FT holo-[Acyl Carrier Protein] synthase (EC 2.7.8.7) (see FT citation below), equivalent to FT Q9X7E3|ACPS_MYCLE|ML1192|MLCB458.07 HOLO-[ACYL-CARRIER FT PROTEIN] SYNTHASE from Mycobacterium leprae (130 aa), FASTA FT scores: opt: 732, E(): 5.5e-42, (87.5% identity in 128 aa FT overlap). Also similar to others e.g. FT O86785|ACPS_STRCO|SC6G4.22c from Streptomyces coelicolor FT (123 aa), FASTA scores: opt: 204, E(): 6.6e-07, (36.7% FT identity in 139 aa overlap); Q9KPB6|VC2457 from Vibrio FT cholerae (126 aa), FASTA scores: opt: 163, E(): 0.00036, FT (32.55% identity in 129 aa overlap); FT P24224|ACPS_ECOLI|DPJ|B2563 from Escherichia coli strain FT K12 (125 aa), FASTA scores: opt: 151, E(): 0.0022, (30.55% FT identity in 131 aa overlap); etc. BELONGS TO THE ACPS FT FAMILY. TBparse score is 0.859." FT /db_xref="GOA:P0A4W8" FT /db_xref="HSSP:1F7L" FT /db_xref="InterPro:IPR004568" FT /db_xref="UniProtKB/Swiss-Prot:P0A4W8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16019.1" FT /translation="MGIVGVGIDLVSIPDFAEQVDQPGTVFAETFTPGERRDASDKSSS FT AARHLAARWAAKEAVIKAWSGSRFAQRPVLPEDIHRDIEVVTDMWGRPRVRLTGAIAEY FT LADVTIHVSLTHEGDTAAAVAILEAP" FT CDS complement(67087..76296) FT /transl_table=11 FT /gene="fas" FT /locus_tag="Rv2524c" FT /product="PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID FT SYNTHETASE)" FT /function="INVOLVED IN LIPID METABOLISM. FATTY ACID FT SYNTHETASE CATALYZES THE FORMATION OF LONG-CHAIN FATTY FT ACIDS FROM ACETYL-COA, MALONYL-CoA AND NADPH." FT /EC_number="2.3.1.-" FT /note="Rv2524c, (MTCY159.32, MTV009.09c), len: 3069 aa. FT Probable fas, Fatty Acid Synthase (EC 2.3.1.-), equivalent FT to Q9X7E2|FAS|ML1191 PUTATIVE TYPE I FATTY ACID SYNTHASE FT from Mycobacterium leprae (3076 aa), FASTA scores: opt: FT 17484, E(): 0, (85.8% identity in 3081 aa overlap). Also FT similar to others e.g. Q04846|FAS|Q59497 from FT Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) FT (3104 aa), FASTA scores: opt: 3981, E(): 5.5e-203, (49.8% FT identity in 3099 aa overlap); Q48926|FAS from Mycobacterium FT bovis (2796 aa), FASTA scores: opt: 2098, E(): 3.9e-103, FT (59.7% identity in 2862 aa overlap) (see Fernandes et al., FT 1996); P34731|FAS1_CANAL FATTY ACID SYNTHASE SUBUNIT BETA FT from Candida albicans (Yeast) (2037 aa), FASTA scores: opt: FT 955, E(): 1.3e-42, (27.4% identity in 1926 aa overlap); FT etc. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00606 Beta-ketoacyl synthases active site." FT /db_xref="GOA:P95029" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95029" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06201.1" FT /translation="MTIHEHDRVSADRGGDSPHTTHALVDRLMAGEPYAVAFGGQGSAW FT LETLEELVSATGIETELATLVGEAELLLDPVTDELIVVRPIGFEPLQWVRALAAEDPVP FT SDKHLTSAAVSVPGVLLTQIAATRALARQGMDLVATPPVAMAGHSQGVLAVEALKAGGA FT RDVELFALAQLIGAAGTLVARRRGISVLGDRPPMVSVTNADPERIGRLLDEFAQDVRTV FT LPPVLSIRNGRRAVVITGTPEQLSRFELYCRQISEKEEADRKNKVRGGDVFSPVFEPVQ FT VEVGFHTPRLSDGIDIVAGWAEKAGLDVALARELADAILIRKVDWVDEITRVHAAGARW FT ILDLGPGDILTRLTAPVIRGLGIGIVPAATRGGQRNLFTVGATPEVARAWSSYAPTVVR FT LPDGRVKLSTKFTRLTGRSPILLAGMTPTTVDAKIVAAAANAGHWAELAGGGQVTEEIF FT GNRIEQMAGLLEPGRTYQFNALFLDPYLWKLQVGGKRLVQKARQSGAAIDGVVISAGIP FT DLDEAVELIDELGDIGISHVVFKPGTIEQIRSVIRIATEVPTKPVIMHVEGGRAGGHHS FT WEDLDDLLLATYSELRSRANITVCVGGGIGTPRRAAEYLSGRWAQAYGFPLMPIDGILV FT GTAAMATKESTTSPSVKRMLVDTQGTDQWISAGKAQGGMASSRSQLGADIHEIDNSASR FT CGRLLDEVAGDAEAVAERRDEIIAAMAKTAKPYFGDVADMTYLQWLRRYVELAIGEGNS FT TADTASVGSPWLADTWRDRFEQMLQRAEARLHPQDFGPIQTLFTDAGLLDNPQQAIAAL FT LARYPDAETVQLHPADVPFFVTLCKTLGKPVNFVPVIDQDVRRWWRSDSLWQAHDARYD FT ADAVCIIPGTASVAGITRMDEPVGELLDRFEQAAIDEVLGAGVEPKDVASRRLGRADVA FT GPLAVVLDAPDVRWAGRTVTNPVHRIADPAEWQVHDGPENPRATHSSTGARLQTHGDDV FT ALSVPVSGTWVDIRFTLPANTVDGGTPVIATEDATSAMRTVLAIAAGVDSPEFLPAVAN FT GTATLTVDWHPERVADHTGVTATFGEPLAPSLTNVPDALVGPCWPAVFAAIGSAVTDTG FT EPVVEGLLSLVHLDHAARVVGQLPTVPAQLTVTATAANATDTDMGRVVPVSVVVTGADG FT AVIATLEERFAILGRTGSAELADPARAGGAVSANATDTPRRRRRDVTITAPVDMRPFAV FT VSGDHNPIHTDRAAALLAGLESPIVHGMWLSAAAQHAVTATDGQARPPARLVGWTARFL FT GMVRPGDEVDFRVERVGIDQGAEIVDVAARVGSDLVMSASARLAAPKTVYAFPGQGIQH FT KGMGMEVRARSKAARKVWDTADKFTRDTLGFSVLHVVRDNPTSIIASGVHYHHPDGVLY FT LTQFTQVAMATVAAAQVAEMREQGAFVEGAIACGHSVGEYTALACVTGIYQLEALLEMV FT FHRGSKMHDIVPRDELGRSNYRLAAIRPSQIDLDDADVPAFVAGIAESTGEFLEIVNFN FT LRGSQYAIAGTVRGLEALEAEVERRRELTGGRRSFILVPGIDVPFHSRVLRVGVAEFRR FT SLDRVMPRDADPDLIIGRYIPNLVPRLFTLDRDFIQEIRDLVPAEPLDEILADYDTWLR FT ERPREMARTVFIELLAWQFASPVRWIETQDLLFIEEAAGGLGVERFVEIGVKSSPTVAG FT LATNTLKLPEYAHSTVEVLNAERDAAVLFATDTDPEPEPEEDEPVAESPAPDVVSEAAP FT VAPAASSAGPRPDDLVFDAADATLALIALSAKMRIDQIEELDSIESITDGASSRRNQLL FT VDLGSELNLGAIDGAAESDLAGLRSQVTKLARTYKPYGPVLSDAINDQLRTVLGPSGKR FT PGAIAERVKKTWELGEGWAKHVTVEVALGTREGSSVRGGAMGHLHEGALADAASVDKVI FT DAAVASVAARQGVSVALPSAGSGGGATIDAAALSEFTDQITGREGVLASAARLVLGQLG FT LDDPVNALPAAPDSELIDLVTAELGADWPRLVAPVFDPKKAVVFDDRWASAREDLVKLW FT LTDEGDIDADWPRLAERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGAENPE FT PGRYGGEVAVVTGASKGSIAASVVARLLDGGATVIATTSKLDEERLAFYRTLYRDHARY FT GAALWLVAANMASYSDVDALVEWIGTEQTESLGPQSIHIKDAQTPTLLFPFAAPRVVGD FT LSEAGSRAEMEMKVLLWAVQRLIGGLSTIGAERDIASRLHVVLPGSPNRGMFGGDGAYG FT EAKSALDAVVSRWHAESSWAARVSLAHALIGWTRGTGLMGHNDAIVAAVEEAGVTTYST FT DEMAALLLDLCDAESKVAAARSPIKADLTGGLAEANLDMAELAAKAREQMSAAAAVDED FT AEAPGAIAALPSPPRGFTPAPPPQWDDLDVDPADLVVIVGGAEIGPYGSSRTRFEMEVE FT NELSAAGVLELAWTTGLIRWEDDPQPGWYDTESGEMVDESELVQRYHDAVVQRVGIREF FT VDDGAIDPDHASPLLVSVFLEKDFAFVVSSEADARAFVEFDPEHTVIRPVPDSTDWQVI FT RKAGTEIRVPRKTKLSRVVGGQIPTGFDPTVWGISADMAGSIDRLAVWNMVATVDAFLS FT SGFSPAEVMRYVHPSLVANTQGTGMGGGTSMQTMYHGNLLGRNKPNDIFQEVLPNIIAA FT HVVQSYVGSYGAMIHPVAACATAAVSVEEGVDKIRLGKAQLVVAGGLDDLTLEGIIGFG FT DMAATADTSMMCGRGIHDSKFSRPNDRRRLGFVEAQGGGTILLARGDLALRMGLPVLAV FT VAFAQSFGDGVHTSIPAPGLGALGAGRGGKDSPLARALAKLGVAADDVAVISKHDTSTL FT ANDPNETELHERLADALGRSEGAPLFVVSQKSLTGHAKGGAAVFQMMGLCQILRDGVIP FT PNRSLDCVDDELAGSAHFVWVRDTLRLGGKFPLKAGMLTSLGFGHVSGLVALVHPQAFI FT ASLDPAQRADYQRRADARLLAGQRRLASAIAGGAPMYQRPGDRRFDHHAPERPQEASML FT LNPAARLGDGEAYIG" FT misc_feature complement(68116..68166) FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature complement(70036..70059) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(76816..77538) FT /transl_table=11 FT /locus_tag="Rv2525c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2525c, (MTCY159.31), len: 240 aa. Conserved FT hypothetical protein, equivalent to FT Q9X7E1|ML1190|MLCB458.05 HYPOTHETICAL 25.3 KDA PROTEIN from FT Mycobacterium leprae (239 aa), FASTA scores: opt: 1358, FT E(): 1e-75, (82.15% identity in 241 aa overlap)." FT /db_xref="InterPro:IPR019546" FT /db_xref="UniProtKB/TrEMBL:P95028" FT /protein_id="CAB06183.1" FT /translation="MSVSRRDVLKFAAATPGVLGLGVVASSLRAAPASAGSLGTLLDYA FT AGVIPASQIRAAGAVGAIRYVSDRRPGGAWMLGKPIQLSEARDLSGNGLKIVSCYQYGK FT GSTADWLGGASAGVQHARRGSELHAAAGGPTSAPIYASIDDNPSYEQYKNQIVPYLRSW FT ESVIGHQRTGVYANSKTIDWAVNDGLGSYFWQHNWGSPKGYTHPAAHLHQVEIDKRKVG FT GVGVDVNQILKPQFGQWA" FT CDS 78055..78282 FT /transl_table=11 FT /locus_tag="Rv2526" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2526, (MTCY159.30c), len: 75 aa. Hypothetical FT unknown protein. TBparse score is 0.877." FT /db_xref="InterPro:IPR019239" FT /db_xref="UniProtKB/TrEMBL:P95027" FT /protein_id="CAB06182.1" FT /translation="MTVKRTTIELDEDLVRAAQAVTGETLRATVERALQQLVAAAAEQA FT AARRRRIVDHLAHAGTHVDADVLLSEQAWR" FT CDS 78279..78680 FT /transl_table=11 FT /locus_tag="Rv2527" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2527, (MTCY159.29c), len: 133 aa. Hypothetical FT protein, showing some similarity to hypothetical proteins FT from Mycobacterium tuberculosis e.g. FT P95007|MTCY159.10c|Rv2546 (137 aa), FASTA scores: opt: 206, FT E(): 1.4e-07, (38.0% identity in 100 aa overlap); FT O33299|MTV002.22c|Rv2757c (138 aa), FASTA scores: opt: 201, FT E(): 3.1e-07, (35.7% identity in 126 aa overlap); and FT P96411|MTCY08D5.24c|Rv0229c (226 aa), FASTA scores: opt: FT 153, E(): 0.0011, (32.8% identity in 128 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:P95026" FT /protein_id="CAB06181.1" FT /translation="MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARS FT ATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHR FT AGVLHHDRDYKRIAVVRPGFQACELSRGR" FT CDS complement(78715..79635) FT /transl_table=11 FT /gene="mrr" FT /locus_tag="Rv2528c" FT /product="PROBABLE RESTRICTION SYSTEM PROTEIN MRR" FT /function="INVOLVED IN THE ACCEPTANCE OF FOREIGN DNA WHICH FT IS MODIFIED. RESTRICTS BOTH ADENINE- AND FT CYTOSINE-METHYLATED DNA." FT /note="Rv2528c, (MTCY159.28), len: 306 aa. Probable mrr, FT restriction system protein, similar to other mrr proteins FT e.g. Q9RWS8|DR0587|MRR from Deinococcus radiodurans (306 FT aa), FASTA scores: opt: 776, E(): 4.2e-40, (40.45% identity FT in 309 aa overlap); P24202|MRR_ECOLI|B4351 from Escherichia FT coli strain K12 (304 aa), FASTA scores: opt: 647, E(): FT 2.9e-32, (35.25% identity in 309 aa overlap); Q9RX07|DR0508 FT from Deinococcus radiodurans (336 aa), FASTA scores: opt: FT 456, E(): 1.3e-20, (37.3% identity in 319 aa overlap); FT etc." FT /db_xref="GOA:P95025" FT /db_xref="InterPro:IPR007560" FT /db_xref="UniProtKB/TrEMBL:P95025" FT /protein_id="CAB06180.1" FT /translation="MTIPDAQTLMRPILAYLADGQAKSAKDVIAAMSDEFGLSDDERAQ FT MLPSGRQRTMYDRVHWSLTHMSQAGLLDRPTRGHVQVTDTGRQVLKAHPERVDMAVLRE FT FPSYIAFRERTKAKQPVDATAKRPSGDDVQVSPEDLIDAALAENRAAVEGEILKKALTL FT SPTGFEDLVIRLLEAMGYGRAGAVERTSASGDAGIDGIISQDPLGLDRIYVQAKRYAVD FT QTIGRPKIHEFAGALLGKQGDRGVYITTSSFSRGAREEAERINARIELIDGARLAELLV FT RYRVGVQAVQTVELLRLDEDFFDGL" FT CDS 79839..81230 FT /transl_table=11 FT /locus_tag="Rv2529" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2529, (MTCY159.27c), len: 463 aa. Hypothetical FT unknown protein. Note that C-terminal part is similar to FT short region of Q53609|MTS1_STRAL|SALIM MODIFICATION FT METHYLASE SALI from Streptomyces albus G (587 aa), FASTA FT scores: opt: 170, E(): 0.016, (59.45% identity in 37 aa FT overlap)." FT /db_xref="GOA:P95024" FT /db_xref="InterPro:IPR006166" FT /db_xref="UniProtKB/TrEMBL:P95024" FT /protein_id="CAB06179.1" FT /translation="MHLAHRVASSRDTPSSSATPNAVSGSASNAADRPCLVRPPTAPPW FT AHGPRLRRDPTGGGSTPSIVLSRSTDRSKDGHRIVPAGARKSGVRASTGRLPSTRKTTR FT SPDCRPSASRTAFGTVTCPFDVTMGSSECLLHRCRTPPVPSHSVELLVAANPAEDSRLP FT YLIRLPVGAGLVFATSDVWPRTKALYCHRLDIADWPADPVVVDRVELRSCSRRGAAIDV FT VAARARENRSQLVHTMARGRQVVFWQSPKTRKQSRPGVRTPTARAAGIPELHIVVDAHE FT RYPYTFADKPAKTTREALPCGDYGLKVAGQLVAAVERKALADLTSGVLNGNLKYQLTEL FT AALPRAAVVVEDRYSEIFAHSFARPTAIADGLAELQIGFPNVPIVFCQTRKLAQEYTYR FT YLAAALTWFVDDADATTVFEPAAAEPEPSSAELRAWAKSVGLPVSDRGRLRPQILQAWR FT AAHPR" FT CDS complement(81231..81650) FT /transl_table=11 FT /locus_tag="Rv2530c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2530c, (MTCY159.26), len: 139 aa. Conserved FT hypothetical protein, highly similar to two HYPOTHETICAL FT PROTEINS from Mycobacterium tuberculosis (strains H37Rv and FT CDC1551): O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: FT opt: 380, E(): 3.6e-19, (48.0% identity in 125 aa overlap); FT and O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt: FT 286, E(): 9.3e-13, (41.35% identity in 133 aa overlap); and FT similar to others e.g. O07760|Rv0617|MTCY19H5.04c (133 aa), FT FASTA scores: opt: 158, E(): 0.00048, (39.55% identity in FT 129 aa overlap). Also some similarity with FT CAC48798|SMB20412 CONSERVED HYPOTHETICAL PROTEIN from FT Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB FT (54 aa), FASTA scores: opt: 184, E(): 3.7e-06, (53.85% FT identity in 52 aa overlap); and CAC48797|SMB20411 CONSERVED FT HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium FT meliloti) plasmid pSymB (82 aa), FASTA scores: opt: 170, FT E(): 4.8e-05, (44.45% identity in 63 aa overlap)." FT /db_xref="InterPro:IPR006226" FT /db_xref="UniProtKB/TrEMBL:P95023" FT /protein_id="CAB06178.1" FT /translation="MTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAG FT YVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTFWPDDVPLIVGSAGDRDAVSNHRRV FT TDCHLIALAARYGGRLVTFDAALADSASAGLVEVL" FT CDS complement(81647..81871) FT /transl_table=11 FT /locus_tag="Rv2530A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2530A, len: 74 aa. Conserved hypothetical protein, FT similar to Q9CCR7|ML0525 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (58 aa), FASTA scores: opt: 179, E(): FT 1.8e-06, (63.65% identity in 44 aa overlap). Highly similar FT to O53218|Rv2493 from Mycobacterium tuberculosis (73 aa), FT FASTA scores: opt: 240, E(): 5.7e-11, (56.75% identity in FT 74 aa overlap); and Q92WE1|RB0399|SMB20413 HYPOTHETICAL FT PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti)p FT lasmid pSymB (megaplasmid 2) (75 aa), FASTA scores: opt: FT 226, E(): 6.5e-10, (56.00% identity in 75 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q8VJG5" FT /protein_id="CAE55498.1" FT /translation="MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVE FT VDGFPVFDVPPDAPTVTSEDVVRALEDDV" FT CDS complement(81902..84745) FT /transl_table=11 FT /locus_tag="Rv2531c" FT /standard_name="adi" FT /product="PROBABLE AMINO ACID DECARBOXYLASE" FT /function="UNKNOWN. COULD BE AN ORNITHINE/ARGININE/LYSINE FT DECARBOXYLASE INVOLVED IN THE BIOSYNTHESIS OF SPERMIDINE FT FROM ARGININE." FT /EC_number="4.1.1.-" FT /note="Rv2531c, (MTCY159.25), len: 947 aa. Probable amino FT acid decarboxylase (EC 4.1.1.-), equivalent to FT Q9CCR8|ADI|ML0524 PUTATIVE AMINO ACID DECARBOXYLASE from FT Mycobacterium leprae (950 aa), FASTA scores: opt: 5426, FT E(): 0, (86.45% identity in 951 aa overlap). Also similar FT to other amino acid decarboxylases (but longer in FT N-terminus) e.g. Q9I2S7|PA1818 PROBABLE ORN/ARG/LYS AMINO FT ACID DECARBOXYLASE from Pseudomonas aeruginosa (751 aa), FT FASTA scores: opt: 434, E(): 2.5e-19, (29.15% identity in FT 738 aa overlap); Q9CML3|SPEF|PM0806 ORNITHINE DECARBOXYLASE FT from Pasteurella multocida (720 aa), FASTA scores: opt: FT 402, E(): 2.4e-17, (24.85% identity in 752 aa overlap); FT P21169|DCOR_ECOLI|SPEC|B2965|BAB37264|ECS3841|AAG58096 FT ORNITHINE DECARBOXYLASE ISOZYME (CONSTITUTIVE ENZYME) from FT Escherichia coli strain K12 (711 aa), FASTA scores: opt: FT 396, E(): 5.6e-17, (28.0% identity in 646 aa overlap); FT P44317|DCOR_HAEIN|SPEF|HI0591 ORNITHINE DECARBOXYLASE from FT Haemophilus influenzae (720 aa), FASTA scores: opt: 393, FT E(): 8.8e-17, (25.05% identity in 743 aa overlap) ; etc. FT SEEMS TO BELONG TO FAMILY 1 OF ORNITHINE, LYSINE, AND FT ARGININE DECARBOXYLASES. Note that previously known as FT adi." FT /db_xref="GOA:Q7D6Y7" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/TrEMBL:Q7D6Y7" FT /protein_id="CAE55499.1" FT /translation="MNPNSVRPRRLHVSALAAVANPSYTRLDTWNLLDDACRHLAEVDL FT AGLDTTHDVARAKRLMDRIGAYERYWLYPGAQNLATFRAHLDSHSTVRLTEEVSLAVRL FT LSEYGDRTALFDTSASLAEQELVAQAKQQQFYTVLLADDSPATAPDSLAECLRQLRNPA FT DEVQFELLVVASIEDAITAVALNGEIQAAIIRHDLPLRSRDRVPLMTTLLGTDGDEAVA FT NETHDWVECAEWIRELRPHIDLYLLTDESIAAETQDEPDVYDRTFYRLNDVTDLHSTVL FT AGLRNRYATPFFDALRAYAAAPVGQFHALPVARGASIFNSKSLHDMGEFYGRNIFMAET FT STTSGGLDSLLDPHGNIKTAMDKAAVTWNANQTYFVTNGTSTANKIVVQALTRPGDIVL FT IDRNCHKSHHYGLVLAGAYPMYLDAYPLPQYAIYGAVPLRTIKQALLDLEAAGQLHRVR FT MLLLTNCTFDGVVYNPRRVMEEVLAIKPDICFLWDEAWYAFATAVPWARQRTAMIAAER FT LEQMLSTAEYAEEYRNWCASMDGVDRSEWVDHRLLPDPNRARVRVYATHSTHKSLSALR FT QASMIHVRDQDFKALTRDAFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFELVRHVY FT NMALVFRHRVRKDRLISKWFRILDESDLVPDAFRSSTVSSYRQVRQGALADWNEAWRSD FT QFVLDPTRLTLFIGATGMNGYDFREKILMERFGIQINKTSINSVLLIFTIGVTWSSVHY FT LLDVLRRVAIDLDRSQKAASGADLALHRRHVEEITQDLPHLPDFSEFDLAFRPDDASSF FT GDMRSAFYAGYEEADREYVQIGLAGRRLAEGKTLVSTTFVVPYPPGFPVLVPGQLVSKE FT IIYFLAQLDVKEIHGYNPDLGLSVFTQAALARMEAARNAVATVGAALPAFEVPRDASAL FT NGTVNGDSVLQGVAEDA" FT CDS complement(84817..85218) FT /transl_table=11 FT /locus_tag="Rv2532c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2532c, (MTCY159.24), len: 133 aa. Hypothetical FT unknown protein, equivalent to AAK46918 from Mycobacterium FT tuberculosis strain CDC1551 but shorter 157 aa." FT /db_xref="UniProtKB/TrEMBL:P95021" FT /protein_id="CAB06176.1" FT /translation="MTRLELRVVVAAVLAATVVLGAVVCAAYGLTIVASAMSIYALGVG FT AWLYHAIERLILARRISTVRTAAKPLQPLLPVMAAIMGLTQAVVRSLGDVTDLPARRRE FT LSQLPVLRWVDNSGNRANRRIADSDDLAD" FT CDS complement(85218..85688) FT /transl_table=11 FT /gene="nusB" FT /locus_tag="Rv2533c" FT /product="N UTILIZATION SUBSTANCE PROTEIN NUSB (NUSB FT PROTEIN)" FT /function="INVOLVED IN THE TRANSCRIPTION TERMINATION FT PROCESS. INTERACTS WITH RPSJ|NUSE|Rv0700." FT /note="Rv2533c, (MT2608, MTCY159.23), len: 156 aa. nusB, N FT utilization substance protein (see citations below), FT equivalent to Q9CCR9|NUSB_MYCLE|ML0523 N UTILIZATION FT SUBSTANCE PROTEIN B from Mycobacterium leprae (190 aa), FT FASTA scores: opt: 749, E(): 2.6e-41, (75.7% identity in FT 148 aa overlap). Also highly similar to others e.g. FT Q9KXR0|SC9C5.14 from Streptomyces coelicolor (142 aa), FT FASTA scores: opt: 358, E(): 2.7e-16, (45.0% identity in FT 140 aa overlap); P54520|NUSB_BACSU from Bacillus subtilis FT (131 aa), FASTA scores: opt: 315, E(): 1.5e-13, (39.55% FT identity in 129 aa overlap); O83979|NUSB_TREPA|TP1015 from FT Treponema pallidum (141 aa), FASTA scores: opt: 268, E(): FT 1.6e-10, (36.95% identity in 138 aa overlap); etc. BELONGS FT TO THE NUSB FAMILY." FT /db_xref="GOA:P95020" FT /db_xref="InterPro:IPR006027" FT /db_xref="PDB:1EYV" FT /db_xref="UniProtKB/Swiss-Prot:P95020" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06175.1" FT /translation="MSDRKPVRGRHQARKRAVALLFEAEVRGISAAEVVDTRAALAEAK FT PDIARLHPYTAAVARGVSEHAAHIDDLITAHLRGWTLDRLPAVDRAILRVSVWELLHAA FT DVPEPVVVDEAVQLAKELSTDDSPGFVNGVLGQVMLVTPQLRAAAQAVRGGA" FT CDS complement(85691..86254) FT /transl_table=11 FT /gene="efp" FT /locus_tag="Rv2534c" FT /product="PROBABLE ELONGATION FACTOR P EFP" FT /function="INVOLVED IN PEPTIDE BOND SYNTHESIS. STIMULATE FT EFFICIENT TRANSLATION AND PEPTIDE-BOND SYNTHESIS ON NATIVE FT OR RECONSTITUTED 70S RIBOSOMES IN VITRO. PROBABLY FUNCTIONS FT INDIRECTLY BY ALTERING THE AFFINITY OF THE RIBOSOME FOR FT AMINOACYL-TRNA, THUS INCREASING THEIR REACTIVITY AS FT ACCEPTORS FOR PEPTIDYL TRANSFERASE." FT /note="Rv2534c, (MTCY159.22), len: 187 aa. Probable efp, FT elongation factor P, equivalent to Q9CCS0|EFP|ML0522 FT ELONGATION FACTOR P from Mycobacterium leprae (187 aa), FT FASTA scores: opt: 1158, E(): 2.1e-67, (94.1% identity in FT 186 aa overlap). Also highly similar to many e.g. FT Q45288|EFP_CORGL from Corynebacterium glutamicum FT (Brevibacterium flavum) (187 aa), FASTA scores: opt: 843, FT E(): 3.4e-47, (69.5% identity in 187 aa overlap); FT Q9KXQ9|EFP from Streptomyces coelicolor (188 aa), FASTA FT scores: opt: 833, E(): 1.5e-46, (67.0% identity in 188 aa FT overlap); P49778|EFP_BACSU from Bacillus subtilis (185 aa), FT FASTA scores: opt: 607, E(): 4.6e-32, (47.8% identity in FT 182 aa overlap); P33398|EFP_ECOLI|B4147 from Escherichia FT coli strain K12 (187 aa), FASTA scores: opt: 503, E(): FT 1.8e-27, (42.3% identity in 182 aa overlap); etc. BELONGS FT TO THE ELONGATION FACTOR P FAMILY." FT /db_xref="GOA:P64034" FT /db_xref="InterPro:IPR014722" FT /db_xref="UniProtKB/Swiss-Prot:P64034" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06174.1" FT /translation="MATTADFKNGLVLVIDGQLWTITEFQHVKPGKGPAFVRTKLKNVL FT SGKVVDKTFNAGVKVDTATVDRRDTTYLYRDGSDFVFMDSQDYEQHPLPEALVGDAARF FT LLEGMPVQVAFHNGVPLYIELPVTVELEVTHTEPGLQGDRSSAGTKPATLQTGAQINVP FT LFINTGDKLKVDSRDGSYLGRVNA" FT CDS complement(86264..87382) FT /transl_table=11 FT /gene="pepQ" FT /locus_tag="Rv2535c" FT /product="PROBABLE CYTOPLASMIC PEPTIDASE PEPQ" FT /function="UNKNOWN; HYDROLYSES PEPTIDES." FT /EC_number="3.4.-.-" FT /note="Rv2535c, (MTCY159.21), len: 372 aa. Probable pepQ, FT cytoplasmic peptidase (EC 3.4.-.-), equivalent to FT Q9CCS1|PEPQ|ML0521 PUTATIVE CYTOPLASMIC PEPTIDASE from FT Mycobacterium leprae (376 aa), FASTA scores: opt: 1954, FT E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also FT similar to other peptidases e.g. P54518|YQHT_BACSU PUTATIVE FT PEPTIDASE (BELONGS TO PEPTIDASE FAMILY M24B) from Bacillus FT subtilis (353 aa), FASTA scores: opt: 808, E(): 1.6e-39, FT (39.65% identity in 368 aa overlap); Q9KXQ8|SC9C5.16c FT PUTATIVE PEPTIDASE from Streptomyces coelicolor (368 aa), FT FASTA scores: opt: 803, E(): 3.2e-39, (43.15% identity in FT 380 aa overlap); Q9K950|BH2800 XAA-PRO DIPEPTIDASE from FT Bacillus halodurans (355 aa), FASTA scores: opt: 801, E(): FT 4.1e-39, (39.45% identity in 365 aa overlap); etc. Note FT that second part of protein is similar to second part of FT MTCY49.29c|Rv2089c|MT2150|MTCY49.29c PROBABLE DIPEPTIDASE FT (EC 3.4.13.-; BELONGS TO PEPTIDASE FAMILY M24B) from FT Mycobacterium tuberculosis (375 aa) (33.9% identity in 354 FT aa overlap) BLAST RESULTS: Score: 142 bits (359), E: 4e-33, FT Identities: 86/224 (38%), Positives: 119/224 (52%), Gaps: FT 4/224 (1%). COULD BE BELONG TO PEPTIDASE FAMILY M24B." FT /db_xref="GOA:P95018" FT /db_xref="HSSP:1A16" FT /db_xref="InterPro:IPR001714" FT /db_xref="UniProtKB/TrEMBL:P95018" FT /protein_id="CAB06173.1" FT /translation="MTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALLV FT FADERDAVLATDGRYRTQAASQAPDLEVAIERAVGRYLAGRAGEAGVGKLGFESHVVTV FT DGLDALAGALEGKNTELVRASGTVESLREVKDAGELALLRLACEAADAALTDLVARGGL FT RPGRTERQVSRELEALMLDHGADAVSFETIVAAGANSAIPHHRPTDAVLQVGDFVKIDF FT GALVAGYHSDMTRTFVLGKAADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAAARQLI FT ADAGYGEHFGHGLGHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRGGVRIED FT TLVVAGGTPKMPETAGQTPELLTRFPKELAIL" FT CDS 87416..88108 FT /transl_table=11 FT /locus_tag="Rv2536" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2536, (MTCY159.20c), len: 230 aa. Probable FT conserved transmembrane protein, equivalent to FT Q9CCS2|ML0520 PUTATIVE MEMBRANE PROTEIN from Mycobacterium FT leprae (202 aa), FASTA scores: opt: 812, E(): 2e-41, (63.2% FT identity in 201 aa overlap). Also similar in part to FT Q9HMD5|VNG2594c from Halobacterium sp. strain NRC-1 (117 FT aa), FASTA scores: opt: 33.6, E(): 1.8, (33.6% identity in FT 116 aa overlap); and perhaps AAK65752|SMA1996 PUTATIVE ABC FT TRANSPORTER PERMEASE PROTEIN from Rhizobium meliloti FT (Sinorhizobium meliloti) plasmid pSymA (323 aa), FASTA FT scores: opt: 117, E(): 6.1, (30.6% identity in 121 aa FT overlap). TBparse score is 0.876." FT /db_xref="GOA:P95017" FT /db_xref="UniProtKB/TrEMBL:P95017" FT /protein_id="CAB06172.1" FT /translation="MTNWMLRGLAFAAAMVVLRLFQGALINAWQMLSGLISLVLLLLFA FT IGGVVWGVMDGRADAKASPDPDRRQDLAMTWLLAGLVAGALSGAVAWLISLFYKAIYTG FT GPINELTTFAAFTALIVFLVGIVGVAVGRWLVDRQLAKAPVRHHGLAAEHERAADTDVF FT SAVRADDSPTGEMQVAQPEAQTAAVATVEREAPTEVIRTTESDTPTEVIRTDTEADQTK FT PGDEPKKD" FT CDS complement(88112..88555) FT /transl_table=11 FT /gene="aroD" FT /locus_tag="Rv2537c" FT /standard_name="aroQ" FT /product="3-DEHYDROQUINATE DEHYDRATASE AROD (AROQ) FT (3-DEHYDROQUINASE) (TYPE II DHQASE)" FT /function="INVOLVED AT THE THIRD STEP IN THE BIOSYNTHESIS FT OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO FT ACIDS (THE SHIKIMATE PATHWAY). CATALYZE A TRANS-DEHYDRATION FT VIA AN ENOLATE INTERMEDIATE [CATALYTIC ACTIVITY: FT 3-DEHYDROQUINATE = 3-DEHYDROSHIKIMATE + H(2)O]." FT /EC_number="4.2.1.10" FT /note="Rv2537c, (MTCY159.19), len: 147 aa. aroD (alternate FT gene name: aroQ), 3-dehydroquinate dehydratase (EC FT 4.2.1.10) (see citation below), equivalent to FT Q9CCS3|AROD|ML0519 3-DEHYDROQUINATE DEHYDRATASE from FT Mycobacterium leprae (145 aa), FASTA scores: opt: 803, E(): FT 3.4e-46, (85.9% identity in 142 aa overlap). Also highly FT similar to many e.g. P96750|AROQ_CORPS from Corynebacterium FT pseudotuberculosis (146 aa), FASTA scores: opt: 559, E(): FT 4.1e-30, (61.05% identity in 136 aa overlap); Q9K949|BH2801 FT from Bacillus halodurans (145 aa), FASTA scores: opt: 453, FT E(): 4e-23, (52.15% identity in 138 aa overlap); FT P54517|AROQ_BACSU|YQHS from Bacillus subtilis (148 aa), FT FASTA scores: opt: 419, E(): 7.1e-21, (45.3% identity in FT 139 aa overlap); etc. Contains PS01029 Dehydroquinase class FT II signature. BELONGS TO THE TYPE-II 3-DEHYDROQUINASE FT FAMILY." FT /db_xref="GOA:P0A4Z6" FT /db_xref="InterPro:IPR018509" FT /db_xref="PDB:1H05" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Z6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06171.1" FT /translation="MSELIVNVINGPNLGRLGRREPAVYGGTTHDELVALIEREAAELG FT LKAVVRQSDSEAQLLDWIHQAADAAEPVILNAGGLTHTSVALRDACAELSAPLIEVHIS FT NVHAREEFRRHSYLSPIATGVIVGLGIQGYLLALRYLAEHVGT" FT misc_feature complement(88478..88531) FT /note="PS01029 Dehydroquinase class II signature" FT CDS complement(88552..89640) FT /transl_table=11 FT /gene="aroB" FT /locus_tag="Rv2538c" FT /product="3-DEHYDROQUINATE SYNTHASE AROB" FT /function="INVOLVED AT THE SECOND STEP IN THE BIOSYNTHESIS FT OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO FT ACIDS (THE SHIKIMATE PATHWAY) [CATALYTIC ACTIVITY: FT 7-PHOSPHO-3-DEOXY-ARABINO-HEPTULOSONATE = 3-DEHYDROQUINATE FT + ORTHOPHOSPHATE]." FT /EC_number="4.2.3.4" FT /note="Rv2538c, (MTCY159.18), len: 362 aa. aroB, FT 3-dehydroquinate synthase (EC 4.6.1.3) (see citations FT below), equivalent to Q9CCS4|AROB_MYCLE|ML0518 FT 3-DEHYDROQUINATE SYNTHASE from Mycobacterium leprae (361 FT aa), FASTA scores: opt: 2059, E(): 3.3e-117, (87.25% FT identity in 361 aa overlap). Also highly similar to many FT e.g. Q9KXQ6|AROB from Streptomyces coelicolor (363 aa), FT FASTA scores: opt: 1363, E(): 4e-75, (60.05% identity in FT 358 aa overlap); Q9X5D2|AROB_CORGL from Corynebacterium FT glutamicum (Brevibacterium flavum) (366 aa), FASTA scores: FT opt: 1154, E(): 1.7e-62, (50.95% identity in 359 aa FT overlap); P07639|AROB_ECOLI|B3389 from Escherichia coli FT strain K12 (362 aa), FASTA scores: opt: 771, E(): 2.4e-39, FT (40.6% identity in 345 aa overlap); etc. BELONGS TO THE FT DEHYDROQUINATE SYNTHASE FAMILY." FT /db_xref="GOA:P0A4Z4" FT /db_xref="HSSP:1DQS" FT /db_xref="InterPro:IPR016037" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Z4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06200.1" FT /translation="MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRHKVAVVHQ FT PGLAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGRKDALVSL FT GGGAATDVAGFAAATWLRGVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFHQPL FT AVLVDLATLQTLPRDEMICGMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIR FT RAITVKAEVVAADEKESELREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELAR FT LAGRLDDATAQRHRTILSSLGLPVSYDPDALPQLLEIMAGDKKTRAGVLRFVVLDGLAK FT PGRMVGPDPGLLVTAYAGVCAP" FT CDS complement(89637..90167) FT /transl_table=11 FT /gene="aroK" FT /locus_tag="Rv2539c" FT /product="SHIKIMATE KINASE AROK (SK)" FT /function="INVOLVED AT THE FIFTH STEP IN THE BIOSYNTHESIS FT OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO FT ACIDS (THE SHIKIMATE PATHWAY) [CATALYTIC ACTIVITY: ATP + FT SHIKIMATE = ADP + SHIKIMATE 3-PHOSPHATE]." FT /EC_number="2.7.1.71" FT /note="Rv2539c, (MTCY159.17), len: 176 aa. aroK, shikimate FT kinase (EC 2.7.1.71) (see citations below), equivalent to FT Q9CCS5|AROK|ML0517 PUTATIVE SHIKIMATE KINASE from FT Mycobacterium leprae (199 aa), FASTA scores: opt: 852, E(): FT 1.3e-42, (79.65% identity in 167 aa overlap). Also highly FT similar to many e.g. Q9X5D1|AROK_CORG from Corynebacterium FT glutamicum (Brevibacterium flavum) (169 aa), FASTA scores: FT opt: 478, E(): 5.4e-21, (47.0% identity in 168 aa overlap); FT Q9KXQ5|AROK from Streptomyces coelicolor (171 aa), FASTA FT scores: opt: 465, E(): 3.1e-20, (49.1% identity in 167 aa FT overlap); P24167|AROK_ECOLI from Escherichia coli strain FT K12 (172 aa), FASTA scores: opt: 316, E(): 1.3e-11, (38.4% FT identity in 164 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A, and PS01128 Shikimate kinase FT signature. BELONGS TO THE SHIKIMATE KINASE FAMILY." FT /db_xref="GOA:P0A4Z2" FT /db_xref="InterPro:IPR000623" FT /db_xref="PDB:1L4U" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Z2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06199.1" FT /translation="MAPKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSI FT ADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISA FT AEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHIL FT SRLQVPSPSEAAT" FT misc_feature complement(89919..89996) FT /note="PS01128 Shikimate kinase signature" FT misc_feature complement(90120..90143) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(90171..91376) FT /transl_table=11 FT /gene="aroF" FT /locus_tag="Rv2540c" FT /standard_name="aroC" FT /product="PROBABLE CHORISMATE SYNTHASE AROF FT (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE PHOSPHOLYASE)" FT /function="INVOLVED AT THE SEVENTH STEP IN THE BIOSYNTHESIS FT OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO FT ACIDS (THE SHIKIMATE PATHWAY) [CATALYTIC ACTIVITY: FT 5-O-(1-CARBOXYVINYL)-3-PHOSPHOSHIKIMATE = CHORISMATE + FT ORTHOPHOSPHATE]." FT /EC_number="4.2.3.5" FT /note="Rv2540c, (MTCY159.16), len: 401 aa. Probable aroF FT (alternate gene name: aroC), chorismate synthase (EC FT 4.6.1.4), equivalent to Q9CCS6|AROF|ML0516 PUTATIVE FT CHORISMATE SYNTHASE from Mycobacterium leprae (407 aa), FT FASTA scores: opt: 2278, E(): 6.2e-123, (88.05% identity in FT 401 aa overlap). Also highly similar to many e.g. FT Q9X5D0|AROC_CORGL from Corynebacterium glutamicum FT (Brevibacterium flavum) (410 aa), FASTA scores: opt: 1811, FT E(): 3e-96, (70.3% identity in 397 aa overlap); FT Q9KXQ4|AROC_STRCO|AROF|SC9C5.20c from Streptomyces FT coelicolor (394 aa), FASTA scores: opt: 1710, E(): 1.7e-90, FT (67.0% identity in 385 aa overlap); FT Q9KCB7|AROC_BACHD|AROF|BH1656 from Bacillus halodurans (390 FT aa), FASTA scores: opt: 1196, E(): 3.9e-61, (48.7% identity FT in 386 aa overlap); etc. Contains PS00788 Chorismate FT synthase signature 2. BELONGS TO THE CHORISMATE SYNTHASE FT FAMILY. COFACTOR: REDUCED FLAVIN." FT /db_xref="GOA:P63611" FT /db_xref="InterPro:IPR000453" FT /db_xref="PDB:1ZTB" FT /db_xref="UniProtKB/Swiss-Prot:P63611" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06198.1" FT /translation="MLRWITAGESHGRALVAVVEGMVAGVHVTSADIADQLARRRLGYG FT RGARMTFERDAVTVLSGIRHGSTLGGPIAIEIGNTEWPKWETVMAADPVDPAELADVAR FT NAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTVARAFLRQALGVEV FT LSHVISIGASAPYEGPPPRAEDLPAIDASPVRAYDKAAEADMIAQIEAAKKDGDTLGGV FT VEAVALGLPVGLGSFTSGDHRLDSQLAAAVMGIQAIKGVEIGDGFQTARRRGSRAHDEM FT YPGPDGVVRSTNRAGGLEGGMTNGQPLRVRAAMKPISTVPRALATVDLATGDEAVAIHQ FT RSDVCAVPAAGVVVETMVALVLARAALEKFGGDSLAETQRNIAAYQRSVADREAPAARV FT SG" FT misc_feature complement(90954..90974) FT /note="PS00788 Chorismate synthase signature 2" FT CDS 91391..91798 FT /transl_table=11 FT /locus_tag="Rv2541" FT /product="HYPOTHETICAL ALANINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2541, (MTCY159.15c), len: 135 aa. Hypothetical FT unknown ala-rich protein, equivalent to AAK46926|MT2615.1 FT HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium FT tuberculosis strain CDC1551 but AAK46926|MT2615.1 longer at FT C-terminus. Questionable ORF. Some similarity with Rv2077A FT from Mycobacterium tuberculosis (99 aa)." FT /db_xref="UniProtKB/TrEMBL:P95012" FT /protein_id="CAB06197.1" FT /translation="MRRRRPPHVNAPTPCDRGDVRPPGCPASIPGVEVAGGTRARLRVT FT ADGLQALAGRCATLAGELSAAVAPSGAVLSWQANAVAVNAAHARAGAAAAAVSARMRAT FT AAALGQAARRYAGQDTAAAAALGAVRPWGTH" FT CDS 92094..93305 FT /transl_table=11 FT /locus_tag="Rv2542" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2542, (MTCY159.14c), len: 403 aa. Conserved FT hypothetical protein, highly similar to AAK46927|MT2616 FT HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium FT tuberculosis strain CDC1551 (265 aa), FASTA scores: opt: FT 1776, E(): 2.3e-94, (99.25% identity in 265 aa overlap). FT And similar to several hypothetical proteins from FT Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g. FT P71654|Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: opt: FT 537, E(): 2.6e-23, (40.75% identity in 292 aa overlap); FT P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 (266 aa), FT FASTA scores: opt: 357, E(): 2.6e-13, (34.6% identity in FT 234 aa overlap); FT Q10685|YK77_MYCTU|Rv2077c|MT2137|MTCY49.16c (323 aa), FASTA FT scores: opt: 261, E(): 9.5e-08, (32.7% identity in 211 aa FT overlap); etc. Also similar to Q9RDQ9|SC4A7.03 PUTATIVE FT SECRETED PROTEIN from Streptomyces coelicolor (406 aa), FT FASTA scores: opt: 247, E(): 7.3e-07, (30.35% identity in FT 303 aa overlap)." FT /db_xref="InterPro:IPR010427" FT /db_xref="UniProtKB/TrEMBL:P95011" FT /protein_id="CAB06196.1" FT /translation="MLDAVSDARRDGFAVGEDYTVTDRSTGGSRQQRAARLGQAQGHAD FT FIRHRVGALLATDRDIATRVSAATQGLDELAFEDVPGVDTPAEDGVQAVDFRQAPPPGA FT PGGMSSGDIDAIDAANRALLQDMLAEYSRLPDGQVKTDRLADIAAIQEALRVPDSHLIY FT VARPDDPADMIPAVTAVGDPFTADHVSVTVPGVSGTTRQTIATMTQETRGLREEARVIA FT HSVGESENVATIAWVGYQPPPVLASWNTVDDDLAQAGAPKLEAFLRDLQAGSHNPGHTT FT ALFGHSYGSLLSGIALKDGASSLVDNAVLYGSPGFDATSPAKLGMNDHNFFVMTTPDDP FT IRYPARLAPLHGWGSDGADTIGTVGRQGTPARVGIRPQRDHRRIPGPLPLHPSADRRGI FT HSAG" FT CDS 93432..94091 FT /transl_table=11 FT /gene="lppA" FT /locus_tag="Rv2543" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPPA" FT /function="UNKNOWN" FT /note="Rv2543, (MTCY159.13c), len: 219 aa. Probable lppA, FT conserved lipoprotein, highly similar to upstream ORF FT P95009|LPPB|Rv2544|MTCY159.12 PUTATIVE LIPOPROTEIN LPPB FT from Mycobacterium tuberculosis (220 aa), FASTA scores: FT opt: 1240, E(): 1.1e-73, (87.15% identity in 218 aa FT overlap). Contains PS00013 Prokaryotic membrane lipoprotein FT lipid attachment site." FT /db_xref="GOA:P95010" FT /db_xref="PDB:2V7S" FT /db_xref="UniProtKB/Swiss-Prot:P95010" FT /protein_id="CAB06195.1" FT /translation="MIAPQPISRTLPRWQRIVALTMIGISTALIGGCTMDHNPDTSRRL FT TGEQKIQLIDSMRNKGSYEAARERLTATARIIADRVSAAIPGQTWKFDDDPNIQQSDRN FT GALCDKLTADIARRPIANSVMFGATFSAEDFKIAANIVREEAAKYGATTESSLFNESAK FT RDYDVQGNGYEFRLLQIKFATLNITGDCFLLQKVLDLPAGQLPPEPPIWPTTSTPH" FT misc_feature 93498..93530 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 94088..94750 FT /transl_table=11 FT /gene="lppB" FT /locus_tag="Rv2544" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPPB" FT /function="UNKNOWN" FT /note="Rv2544, (MTCY159.12c), len: 220 aa. Probable lppB, FT conserved lipoprotein, highly similar to downstream ORF FT P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 PUTATIVE FT LIPOPROTEIN LPPA from Mycobacterium tuberculosis (219 aa), FT FASTA scores: opt: 1242, E(): 4.8e-72, (87.15% identity in FT 218 aa overlap). Contains PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. TBparse score is 0.924." FT /db_xref="GOA:P95009" FT /db_xref="UniProtKB/Swiss-Prot:P95009" FT /protein_id="CAB06194.1" FT /translation="MIAPQPIPRTLPRWQRIVALTMIGISTALIGGCTMGQNPDKSPHL FT TGEQKIQLIDSMRHKGSYEAARERLTATAQIIADRVSAAIPGQTWKFNDDSYGQDFYRN FT GSLCKELSADIARRPMAKPVDFGSTFSAEDFKIAANIVREEAAKYGVTTESSLFNESAK FT RDYDVQGNGYEFNLGQIKFATLNITGDCFLLQKVLDLPAGQLPPEPPIWPTTSTPTP" FT misc_feature 94154..94186 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 94747..95025 FT /transl_table=11 FT /locus_tag="Rv2545" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2545, (MTY159.11c), len: 92 aa. Conserved FT hypothetical protein. C-terminus highly similar to FT O33300|Rv2758c|MTV002.23c PROTEIN from Mycobacterium FT tuberculosis (88 aa), FASTA scores: opt: 151, E(): 9.8e-05, FT (66.65% identity in 45 aa overlap); and FT Q10771|Rv1560|MT1611|MTCY48.05 PROTEIN from Mycobacterium FT tuberculosis (72 aa), FASTA scores: opt: 84, E(): 8.2, FT (46.5% identity in 43 aa overlap)." FT /db_xref="InterPro:IPR019239" FT /db_xref="UniProtKB/TrEMBL:P95008" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06193.1" FT /translation="MSTTIVAGVIQGHLPVILPTRRRARDLGHTTALFRAQTLQCIYLS FT IEYLYVCSMSRRTTIDIDDILLARAQAALGTTGLKDRVDAALRAAVR" FT CDS 95118..95531 FT /transl_table=11 FT /locus_tag="Rv2546" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2546, (MTCY159.10c), len: 137 aa. Conserved FT hypothetical protein. Some similarity to several FT HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis FT (strain H37Rv and CDC1551) e.g. P96411|Rv0229c|MTCY08D5.24c FT (226 aa), FASTA scores: opt: 272, E(): 1.3e-11, (39.7% FT identity in 136 aa overlap); O33299|Rv2757c|MTV002.22c (138 FT aa), FASTA scores: opt: 265, E(): 2.5e-11, (38.5% identity FT in 135 aa overlap); P95026|Rv2527|MTCY159.29c (133 aa), FT FASTA scores: opt: 206, E(): 2.6e-07, (38.0% identity in FT 100 aa overlap); etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:P95007" FT /protein_id="CAB06192.1" FT /translation="MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSA FT NSATDYDALADELDGLARIPVGAETFTRACQVQRELAHVAGLHHRSVKIADLVIAAAAE FT LSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL" FT CDS 95570..95827 FT /transl_table=11 FT /locus_tag="Rv2547" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2547, (MTCY159.09c), len: 85 aa. Conserved FT hypothetical protein. Some similarity to FT P71666|YD98_MYCTU|Rv1398c|MT1442|MTCY21B4.15c HYPOTHETICAL FT 9.4 KDA PROTEIN from Mycobacterium tuberculosis (85 aa), FT FASTA scores: opt: 108, E(): 0.33, (37.1% identity in 62 aa FT overlap); CAC45864|SMC01933 CONSERVED HYPOTHETICAL PROTEIN FT from Rhizobium meliloti (Sinorhizobium meliloti) (71 aa), FT FASTA scores: opt: 105, E(): 0.46, (28.4% identity in 74 aa FT overlap); Q97W38|SSO10342 HYPOTHETICAL PROTEIN from FT Sulfolobus solfataricus (58 aa), FASTA scores: opt: 94, FT E(): 2.3, (46.95% identity in 49 aa overlap)." FT /db_xref="GOA:P95006" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/TrEMBL:P95006" FT /protein_id="CAB06191.1" FT /translation="MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQE FT RLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLARLGLA" FT CDS 95824..96201 FT /transl_table=11 FT /locus_tag="Rv2548" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2548, (MTCY159.08c), len: 125 aa. Conserved FT hypothetical protein. Some similarity to various proteins FT e.g. P71665|Rv1397c|MTCY21B4.14c HYPOTHETICAL 15.0 KDA FT PROTEIN from Mycobacterium tuberculosis (133 aa), FASTA FT scores: opt: 265, E(): 7.1e-12, (42.3% identity in 123 aa FT overlap); Q97WY5|SSO1975 HYPOTHETICAL PROTEIN from FT Sulfolobus solfataricus (125 aa), FASTA scores: opt: 131, FT E(): 0.018, (30.0% identity in 110 aa overlap); O52285|YLE FT HYPOTHETICAL 14.9 KDA PROTEIN from Agrobacterium FT radiobacter (133 aa), FASTA scores: opt: 128, E(): 0.03, FT (32.8% identity in 125 aa overlap); etc. TBscore is 0.865." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:P95005" FT /protein_id="CAB06190.1" FT /translation="MKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLA FT GVRESELAALEAFFSAVVWTLVTEDIARIGGRLARRYRSSHRGIDDVDYLIAATAIVVD FT ADLLTTNVRHFPMFPDLQPPY" FT CDS complement(96691..97086) FT /transl_table=11 FT /locus_tag="Rv2549c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2549c, (MTCY159.07), len: 131 aa. Conserved FT hypothetical protein, showing some similarity to FT P73415|SLL1715 from Synechocystis sp. strain PCC 6803 (157 FT aa), FASTA scores: opt: 167, E(): 4.2e-05, (29.45% identity FT in 129 aa overlap); Q9HHY6|VNG6166H from Halobacterium sp. FT plasmid pNRC200 strain NRC-1 (144 aa), FASTA scores: opt: FT 133, E(): 0.011, (29.6% identity in 125 aa overlap); and FT Q9HSU3|VNG0072H from Halobacterium sp. strain NRC-1 (144 FT aa), FASTA scores: opt: 113, E(): 0.29, (25.75% identity in FT 136 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:P95004" FT /protein_id="CAB06189.1" FT /translation="MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETW FT TLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEEQAWEWLVRHDEREYSFVDATSFAV FT MRKKGIQNAYAFDGDFSAAGFVEVRPE" FT CDS complement(97083..97328) FT /transl_table=11 FT /locus_tag="Rv2550c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2550c, (MTCY159.06), len: 81 aa. Hypothetical FT unknown protein." FT /db_xref="GOA:P95003" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/TrEMBL:P95003" FT /protein_id="CAB06188.1" FT /translation="MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAE FT HLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKHE" FT CDS complement(97739..98158) FT /transl_table=11 FT /locus_tag="Rv2551c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2551c, (MTCY159.05), len: 139 aa. Conserved FT hypothetical protein, similar to the second part of FT Q9XAP1|SC10A7.34c PUTATIVE TYPE IV PEPTIDASE from FT Streptomyces coelicolor (259 aa), FASTA scores: opt: 243, FT E(): 7.4e-08, (40.95% identity in 144 aa overlap). Also FT some similarity with other proteins e.g. AAK58497|GSPO GSPO FT PROTEIN from Acetobacter diazotrophicus (261 aa), FASTA FT scores: opt: 152, E(): 0.025, (33.35% identity in 135 aa FT overlap)." FT /db_xref="GOA:P95002" FT /db_xref="InterPro:IPR000045" FT /db_xref="UniProtKB/TrEMBL:P95002" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06187.1" FT /translation="MLAAAVLAWMGVLCVCDVRQRRLPNWLTLPGAGVILLFAGLAGRG FT VPALAGAAALAGVYLLVHLALPAAMGAGDVKLAIGLGGLTGCFGVEVWFLAALAAPLLT FT AVCGVMVTPWGVRTLPHGPSMCVASLGAVGLALLG" FT CDS complement(98170..98979) FT /transl_table=11 FT /gene="aroE" FT /locus_tag="Rv2552c" FT /product="PROBABLE SHIKIMATE 5-DEHYDROGENASE AROE FT (5-DEHYDROSHIKIMATE REDUCTASE)" FT /function="POSSIBLY INVOLVED AT THE FOURTH STEP IN THE FT BIOSYNTHESIS OF CHORISMATE WITHIN THE BIOSYNTHESIS OF FT AROMATIC AMINO ACIDS (THE SHIKIMATE PATHWAY) [CATALYTIC FT ACTIVITY: SHIKIMATE + NADP(+) = 5-DEHYDROSHIKIMATE + FT NADPH]." FT /EC_number="1.1.1.25" FT /note="Rv2552c, (MTCY159.04), len: 269 aa. Probable aroE, FT shikimate 5-dehydrogenase (EC 1.1.1.25), equivalent to FT Q9CCS7|AROE|ML0515 PUTATIVE SHIKIMATE 5-DEHYDROGENASE from FT Mycobacterium leprae (278 aa), FASTA scores: opt: 1452, FT E(): 1.8e-77, (81.5% identity in 270 aa overlap). Also FT highly similar, but longer 101 aa, to Q9KH59|AROE PUTATIVE FT SHIKIMATE DEHYDROGENASE (FRAGMENT) from Mycobacterium FT marinum (148 aa), FASTA scores: opt: 729, E(): 1.3e-35, FT (76.35% identity in 148 overlap); Q9F7W3|AROE from FT Mycobacterium ulcerans (148 aa), FASTA scores: opt: 718, FT E(): 5.9e-35, (75.7% identity in 148 aa overlap). And also FT similar to to others e.g. Q9KXQ2|AROE from Streptomyces FT coelicolor (255 aa), FASTA scores: opt: 572, E(): 2.8e-26, FT (43.4% identity in 251 aa overlap); Q98DY3|MLR4492 from FT Rhizobium loti (Mesorhizobium loti) (280 aa), FASTA scores: FT opt: 385, E(): 2.2e-15, (34.85% identity in 284 aa FT overlap); P74591|AROE_SYNY3|SLR1559 from Synechocystis sp. FT strain PCC 6803 (290 aa), FASTA scores: opt: 347, E(): FT 3.7e-13, (30.9% identity in 275 aa overlap); FT P15770|AROE_ECOLI|B3281 from Escherichia coli strain K12 FT (272 aa), FASTA scores: opt: 230, E(): 7.7e-08, (29.5% FT identity in 251 aa overlap); etc. BELONGS TO THE SHIKIMATE FT DEHYDROGENASE FAMILY." FT /db_xref="GOA:P95001" FT /db_xref="HSSP:1NYT" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95001" FT /protein_id="CAB06186.1" FT /translation="MSEGPKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGA FT AELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNT FT DIDGVAGALGAAAGHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTR FT VGVATRFCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPL FT AAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAALD" FT CDS complement(98976..100229) FT /transl_table=11 FT /locus_tag="Rv2553c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2553c, (MTCY159.03), len: 417 aa. Probable FT conserved membrane protein, equivalent to Q9CCS8|ML0514 FT PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (421 FT aa), FASTA scores: opt: 1955, E(): 1.1e-111, (72.7% FT identity in 414 aa overlap). Also similar in part to FT various proteins e.g. Q9L9G6|NOVB NOVB PROTEIN FT (aminodesoxychorismate lyase) from Streptomyces sphaeroides FT (284 aa), FASTA scores: opt: 451, E(): 2.9e-2, (37.95% FT identity in 203 aa overlap); Q9EWY3|2SCG38.36 CONSERVED FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (253 aa), FT FASTA scores: opt: 419, E(): 2.3e-18, (39.2% identity in FT 171 aa overlap); Q9CHT3|YGCC HYPOTHETICAL PROTEIN from FT Lactococcus lactis (subsp. lactis) (Streptococcus lactis) FT (550 aa), FASTA scores: opt: 379, E(): 1.2e-15, (23.0% FT identity in 417 aa overlap); O25309|HP0587 FT AMINODEOXYCHORISMATE LYASE (PABC) from Helicobacter pylori FT (Campylobacter pylori) (329 aa), FASTA scores: opt: 290, FT E(): 2e-10, (31.65% identity in 180 aa overlap); etc." FT /db_xref="InterPro:IPR003770" FT /db_xref="UniProtKB/TrEMBL:P95000" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06185.1" FT /translation="MPDGGHRHRAQPVSVRPNRHRRTRVSRAQRRHAQQIRRRRRVAGG FT FALSLLVVVVVVAVVVGAKLWQTMLGFGNDYTGPGKRDIVIQIRAGDSTTAVGETLLKH FT GVVATVRAFVDAAHGNTAISSIQPGFYRMRTEISAASAVARLTDPHNRVGKLVIPEGRQ FT LDDTTDMKTNVVNPGIFALISRATCVDLDGTQRCVSVADLRAAASRSTPTMLSVPRWAV FT GPVMELGTDHRRIEGLIAPGTFNIDPSASAETILATLISAGAVEYMKSGLVDTAKSLGL FT SPYDILVVASLVQQEANTQDFPKVARVIYNRLHEHRTLEFDSTVNYPLDRREVATSDTD FT RAQRTPWNTYMAQGLPATAICSPGVDALRAAEHPVPGDWLYFVTIDSQGTTLFTRDYQQ FT HLANIELAKHNGVLDSAR" FT CDS complement(100222..100734) FT /transl_table=11 FT /locus_tag="Rv2554c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2554c, (MTCY159.02), len: 170 aa. Conserved FT hypothetical protein, equivalent to Q9CCS9|ML0513 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (184 aa), FT FASTA scores: opt: 701, E(): 2e-34, (72.05% identity in 161 FT aa overlap). Also highly similar to Q9KXQ0|SC9C5.24c FT HYPOTHETICAL 17.7 KDA PROTEIN from Streptomyces coelicolor FT (167 aa), FASTA scores: opt: 461, E(): 2.3e-20, (54.65% FT identity in 150 aa overlap); and similar to other FT hypothetical proteins e.g. Q9KDE4 from Bacillus halodurans FT (140 aa), FASTA scores: opt: 291, E(): 1.9e-10, (38.7% FT identity in 137 aa overlap); P74662|SLL1547 from FT Synechocystis sp. strain PCC 6803 (152 aa), FASTA scores: FT opt: 290, (36.55% identity in 145 aa overlap); FT Q52673|YQGF_RHOCA from Rhodobacter capsulatus FT (Rhodopseudomonas capsulata) (159 aa), FASTA scores: opt: FT 246, E(): 8.4e-08, (34.8% identity in 135 aa overlap); FT etc." FT /db_xref="GOA:P67487" FT /db_xref="InterPro:IPR006641" FT /db_xref="UniProtKB/Swiss-Prot:P67487" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06184.1" FT /translation="MVPAQHRPPDRPGDPAHDPGRGRRLGIDVGAARIGVACSDPDAIL FT ATPVETVRRDRSGKHLRRLAALAAELEAVEVIVGLPRTLADRIGRSAQDAIELAEALAR FT RVSPTPVRLADERLTTVSAQRSLRQAGVRASEQRAVIDQAAAVAILQSWLDERLAAMAG FT TQEGSDA" FT CDS complement(100735..103449) FT /transl_table=11 FT /gene="alaS" FT /locus_tag="Rv2555c" FT /product="PROBABLE ALANYL-TRNA SYNTHETASE ALAS FT (ALANINE--TRNA LIGASE) (ALANINE TRANSLASE) (ALARS)" FT /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC FT ACTIVITY: ATP + L-ALANINE + TRNA(ALA) = AMP + PYROPHOSPHATE FT + L-ALANYL-TRNA(ALA)]." FT /EC_number="6.1.1.7" FT /note="Rv2555c, (MTCY318.01c-MTCY159.01), len: 904 aa. FT Probable alaS, alanyl-tRNA synthetase (EC 6.1.1.7), FT equivalent to Q9CCT0|ALAS|ML0512 ALANYL-TRNA SYNTHETASE FT from Mycobacterium leprae (908 aa), FASTA scores: opt: FT 5013, E(): 0, (84.65% identity in 907 aa overlap). Also FT highly similar to many e.g. Q9KXP9|ALAS from Streptomyces FT coelicolor (890 aa), FASTA scores: opt: 2159, E(): FT 3.8e-118, (53.45% identity in 907 aa overlap); Q9FFC7 FT Arabidopsis thaliana (Mouse-ear cress) (954 aa), FASTA FT scores: opt: 1963, E(): 1.1e-106, (41.1% identity in 925 aa FT overlap); Q9RS27|DR2300 from Deinococcus radiodurans (890 FT aa), FASTA scores: opt: 1352, E(): 4.1e-71, (38.05% FT identity in 915 aa overlap); etc. BELONGS TO CLASS-II FT AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:O07438" FT /db_xref="InterPro:IPR012947" FT /db_xref="UniProtKB/Swiss-Prot:O07438" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09762.1" FT /translation="MQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQFV FT PFFLGQRTPPYPTATSIQKCIRTPDIDEVGITTRHNTFFQMAGNFSFGDYFKRGAIELA FT WALLTNSLAAGGYGLDPERIWTTVYFDDDEAVRLWQEVAGLPAERIQRRGMADNYWSMG FT IPGPCGPSSEIYYDRGPEFGPAGGPIVSEDRYLEVWNLVFMQNERGEGTTKEDYQILGP FT LPRKNIDTGMGVERIALVLQDVHNVYETDLLRPVIDTVARVAARAYDVGNHEDDVRYRI FT IADHSRTAAILIGDGVSPGNDGRGYVLRRLLRRVIRSAKLLGIDAAIVGDLMATVRNAM FT GPSYPELVADFERISRIAVAEETAFNRTLASGSRLFEEVASSTKKSGATVLSGSDAFTL FT HDTYGFPIELTLEMAAETGLQVDEIGFRELMAEQRRRAKADAAARKHAHADLSAYRELV FT DAGATEFTGFDELRSQARILGIFVDGKRVPVVAHGVAGGAGEGQRVELVLDRTPLYAES FT GGQIADEGTISGTGSSEAARAAVTDVQKIAKTLWVHRVNVESGEFVEGDTVIAAVDPGW FT RRGATQGHSGTHMVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGPLTDDQRTQVEEV FT TNEAVQADFEVRTFTEQLDKAKAMGAIALFGESYPDEVRVVEMGGPFSLELCGGTHVSN FT TAQIGPVTILGESSIGSGVRRVEAYVGLDSFRHLAKERALMAGLASSLKVPSEEVPARV FT ANLVERLRAAEKELERVRMASARAAATNAAAGAQRIGNVRLVAQRMSGGMTAADLRSLI FT GDIRGKLGSEPAVVALIAEGESQTVPYAVAANPAAQDLGIRANDLVKQLAVAVEGRGGG FT KADLAQGSGKNPTGIDAALDAVRSEIAVIARVG" FT CDS complement(103540..103929) FT /transl_table=11 FT /locus_tag="Rv2556c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2556c, (MTCY09C4.12), len: 129 aa. Conserved FT hypothetical protein, highly similar to others e.g. FT Q9EWY5|2SCG38.34 CONSERVED HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor (140 aa), FASTA scores: opt: 488, FT E(): 8.2e-26, (58.8% identity in 131 aa overlap); FT Q9L9G4|NOVD NOVD PROTEIN from Streptomyces sphaeroides (143 FT aa), FASTA scores: opt: 474, E(): 7.2e-25, (60.85% identity FT in 120 aa overlap); Q9X2I5|TM1872 from Thermotoga maritima FT (132 aa), FASTA scores: opt: 270, E(): 2.7e-11, (39.55% FT identity in 129 aa overlap); etc." FT /db_xref="InterPro:IPR001602" FT /db_xref="UniProtKB/Swiss-Prot:P67121" FT /protein_id="CAB01048.1" FT /translation="MLDVDTARRRIVDLTDAVRAFCTAHDDGLCNVFVPHATAGVAIIE FT TGAGSDEDLVDTLVRLLPRDDRYRHAHGSYGHGADHLLPAFVAPSVTVPVSGGQPLLGT FT WQSIVLVDLNQDNPRRSVRLSFVEG" FT CDS 104036..104710 FT /transl_table=11 FT /locus_tag="Rv2557" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN; THOUGHT TO BE INVOLVED IN THE FT PERSISTENCE IN THE HOST." FT /note="Rv2557, (MTCY9C4.11c), len: 224 aa. Conserved FT hypothetical protein, highly similar to upstream ORF FT Q50740|MTCY9C4.10c|Rv2558|MT2635 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (236 aa), FASTA FT scores: opt: 1007, E(): 6.9e-60, (69.2% identity in 224 aa FT overlap); and Mb2587 in Mycobacterium bovis (224 aa)." FT /db_xref="UniProtKB/Swiss-Prot:P65003" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01047.1" FT /translation="MTGGATGALPRTMKEGWIVYARSTTIQAQSECIDTGIAHVRDVVM FT PALQGMDGCIGVSLLVDRQSGRCIATSAWETAEAMHASREQVTPIRDRCAEMFGGTPAV FT EEWEIAAMHRDHRSAEGACVRATWVKVPADQVDQGIEYYKSSVLPQIEGLDGFCSASLL FT VDRTSGRAVSSATFDSFDAMERNRDQSNALKATSLREAGGEELDECEFELALAHLRVPE FT LV" FT CDS 104795..105505 FT /transl_table=11 FT /locus_tag="Rv2558" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN; THOUGHT TO BE INVOLVED IN THE FT PERSISTENCE IN THE HOST." FT /note="Rv2558, (MTCY9C4.10c), len: 236 aa. Conserved FT hypothetical protein, highly similar to downstream ORF FT Q50741|MTCY9C4.11c|Rv2557|MT2645 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (224 aa), FASTA FT scores: opt: 1007, E(): 4.7e-59, (69.2% identity in 224 aa FT overlap); and Mb2588 in Mycobacterium bovis (236 aa)." FT /db_xref="UniProtKB/Swiss-Prot:P65005" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01046.1" FT /translation="MPGSAGWRKVFGGTGGATGALPRHGRGSIVYARSTTIEAQPLSVD FT IGIAHVRDVVMPALQEIDGCVGVSLLVDRQSGRCIATSAWETLEAMRASVERVAPIRDR FT AALMFAGSARVEEWDIALLHRDHPSHEGACVRATWLKVVPDQLGRSLEFYRTSVLPELE FT SLDGFCSASLMVDHPACRRAVSCSTFDSMDAMARNRDRASELRSRRVRELGAEVLDVAE FT FELAIAHLRVPELV" FT CDS complement(105535..106893) FT /transl_table=11 FT /locus_tag="Rv2559c" FT /product="CONSERVED HYPOTHETICAL ALANINE LEUCINE VALINE FT RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2559c, (MTCY9C4.09), len: 452 aa. Conserved FT hypothetical ala-, leu-, val-rich protein, equivalent to FT Q9CCT1|ML0510 HYPOTHETICAL PROTEIN from Mycobacterium FT leprae (473 aa), FASTA scores: opt: 2411, E(): 3.9e-121, FT (83.4% identity in 452 aa overlap); O69490|O69490 FT HYPOTHETICAL 47.1 KDA PROTEIN from Mycobacterium leprae FT (447 aa), FASTA scores: opt: 2406, E(): 6.9e-121, (83.95% FT identity in 448 aa overlap). Also highly similar to FT Q9KXP4|SC9C5.30c CONSERVED ATP/GTP BINDING PROTEIN from FT Streptomyces coelicolor (451 aa), FASTA scores: opt: 1742, FT E(): 1.5e-85, (64.4% identity in 430 aa overlap); FT Q9RT67|DR1898 CONSERVED HYPOTHETICAL PROTEIN from FT Deinococcus radiodurans (434 aa), FASTA scores: opt: 1147, FT E(): 6.6e-54, (46.0% identity in 415 aa overlap); FT P45262|YCAJ_HAEIN|HI1590 HYPOTHETICAL PROTEIN from FT Haemophilus influenzae (446 aa), FASTA scores: opt: 1140, FT E(): 1.6e-53, (42.5% identity in 428 aa overlap); etc. Also FT similar to Q50629|MTCY227.09|RUVB|Rv2592c|MT2669|MTCY227.09 FT HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium FT tuberculosis (344 aa), (30.1% identity in 296 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q50739" FT /db_xref="HSSP:1IN4" FT /db_xref="InterPro:IPR003959" FT /db_xref="UniProtKB/Swiss-Prot:Q50739" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01045.1" FT /translation="MPEAVSDGLFDVPGVPMTSGHDLGASAGAPLAVRMRPASLDEVVG FT QDHLLAPGSPLRRLVEGSGVASVILYGPPGSGKTTLAALISQATGRRFEALSALSAGVK FT EVRAVIENSRKALLHGEQTVLFIDEVHRFSKTQQDALLSAVEHRVVLLVAATTENPSFS FT VVAPLLSRSLILQLRPLTAEDTRAVVQRAIDDPRGLGRAVAVAPEAVDLLVQLAAGDAR FT RALTALEVAAEAAQAAGELVSVQTIERSVDKAAVRYDRDGDQHYDVVSAFIKSVRGSDV FT DAALHYLARMLVAGEDPRFIARRLMILASEDIGMAGPSALQVAVAAAQTVALIGMPEAQ FT LTLAHATIHLATAPKSNAVTTALAAAMNDIKAGKAGLVPAHLRDGHYSGAAALGNAQGY FT KYSHDDPDGVVAQQYPPDELVDVDYYRPTGRGGEREIAGRLDRLRAIIRKKRG" FT misc_feature complement(106657..106680) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 107039..108016 FT /transl_table=11 FT /locus_tag="Rv2560" FT /product="PROBABLE PROLINE AND GLYCINE RICH TRANSMEMBRANE FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv2560, (MTCY9C4.08c), len: 325 aa. Probable FT transmembrane protein, pro-, gly-rich protein." FT /db_xref="GOA:Q50738" FT /db_xref="InterPro:IPR018692" FT /db_xref="UniProtKB/Swiss-Prot:Q50738" FT /protein_id="CAB01044.1" FT /translation="MSQPPEHPGNPADPQGGNQGAGSYPPPGYGAPPPPPGYGPPPGTY FT LPPGYNAPPPPPGYGPPPGPPPPGYPTHLQSSGFSVGDAISWSWNRFTQNAVTLVVPVL FT AYAVALAAVIGATAGLVVALSDRATTAYTNTSGVSSESVDITMTPAAGIVMFLGYIALF FT ALVLYMHAGILTGCLDIADGKPVTIATFFRPRNLGLVLVTGLLIVAVTFIGGLLCVIPG FT LIFGFVAQFAVAFAVDRSTSPIDSVKASIETVGSNIGGSVLSWLAQLTAVLVGELLCFV FT GMLIGIPVAALIHVYTYRKLSGGQVVEAVRPAPPVGWPPGPQLA" FT CDS 108373..108666 FT /transl_table=11 FT /locus_tag="Rv2561" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2561, (MTCY9C4.07c), len: 97 aa. Conserved FT hypothetical protein, highly similar in part (and longer 33 FT aa) to upstream ORF AAK46951|RV2562|MT2638|MTCY9C4.06c FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (212 aa), FASTA scores: opt: 205, E(): 2e-06, FT (76.1% identity in 46 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:Q50737" FT /protein_id="CAB01043.1" FT /translation="MGIQRAVLLIADIGGYTNYMHWNRKHLAHAQWTVAQLLESVIDAA FT KGMKLAKLEGDAAFFWAPGGQHQCPGMRPAPADAPEVPHAARADQKRPSLRL" FT CDS 108722..109111 FT /transl_table=11 FT /locus_tag="Rv2562" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2562, (MTCY9C4.06c), len: 129 aa. Conserved FT hypothetical protein, highly similar, but shorter 83 aa, to FT downstream ORF AAK46951|RV2561|MT2638|MTCY9C4.07c CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (97 FT aa), FASTA scores: opt: 866, E(): 2.2e-54, (100.0% identity FT in 129 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:Q50737" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01042.1" FT /translation="MAEQKVKRNVELAGVDVILVHRMLKNEVPVSEYLFMTDVVAQCLD FT ESVRKLATPLTHDFEGIGETSTHYIDLATSDMPPAVPDHSFFGLLWADVKFEWHALPYL FT LGFKKACAGFRSLGRGATEEPAEMG" FT CDS 109254..110303 FT /transl_table=11 FT /locus_tag="Rv2563" FT /product="PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE FT PROTEIN ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT GLUTAMINE ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2563, (MTCY9C4.05c), len: 349 aa. Probable FT glutamine-transport transmembrane protein ABC transporter FT (see citation below), highly similar to FT O53617|Rv0072|MTV030.16 PUTATIVE ABC-TRANSPORTER FT TRANSMEMBRANE SUBUNIT from Mycobacterium tuberculosis (349 FT aa), FASTA scores: opt: 1772, E(): 1.1e-89, (76.2% identity FT in 349 aa overlap). Also some similarity with various FT hypothetical proteins e.g. Q9RYN1|DRA0279 HYPOTHETICAL 37.1 FT KDA PROTEIN from Deinococcus radiodurans (353 aa), FASTA FT scores: opt: 347, E(): 6.6e-12, (24.35% identity in 357 aa FT overlap); BAB58522|SAV2360 CONSERVED HYPOTHETICAL PROTEIN FT from Staphylococcus aureus subsp. aureus Mu50 (351 aa), FT FASTA scores: opt: 262, E(): 2.9e-07, (19.4% identity in FT 356 aa overlap); Q9AK94|SC10A9.10c PUTATIVE ABC TRANSPORT FT SYSTEM TRANSMEMBRANE PROTEIN from Streptomyces coelicolor FT (379 aa), FASTA scores: opt: 172, E(): 0.025, (26.85% FT identity in 387 aa overlap); etc." FT /db_xref="GOA:P65007" FT /db_xref="InterPro:IPR003838" FT /db_xref="UniProtKB/Swiss-Prot:P65007" FT /protein_id="CAB01052.1" FT /translation="MLFAALRDVQWRKRRLVIAIVSTGLVFAMTLVLTGLVNGFRVEAE FT RTVDSMGVDAFVVKAGAAGPFLGSTPFAQIDLPQVARAPGVLAAAPLATAPSTIRQGTS FT ARNVTAFGAPEHGPGMPRVSDGRAPSTPDEVAVSSTLGRNLGDDLQVGARTLRIVGIVP FT ESTALAKIPNIFLTTEGLQQLAYNGQPTISSIGIDGMPRQLPDGYQTVNRADAVSDLMR FT PLKVAVDAITVVAVLLWIVAALIVGSVVYLSALERLRDFAVFKAIGVPTRSILAGLALQ FT AVVVALLAAVVGGILSLLLAPLFPMTVVVPLSAFVALPAIATVIGLLASVAGLRRVVAI FT DPALAFGGP" FT CDS 110306..111298 FT /transl_table=11 FT /gene="glnQ" FT /locus_tag="Rv2564" FT /product="PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER GLNQ" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT GLUTAMINE ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2564, (MTCY9C4.04c), len: 330 aa. Probable glnQ, FT glutamine-transport ATP-binding protein ABC transporter FT (see citation below), highly similar to many e.g. FT Q9L0J9|SCD40A.12c PUTATIVE ABC-TRANSPORTER ATP-BINDING FT PROTEIN from Streptomyces coelicolor (246 aa), FASTA FT scores: opt: 598, E(): 2.5e-26, (46.35% identity in 218 aa FT overlap); O54136|SC2E9.11 from Streptomyces coelicolor (230 FT aa), FASTA scores: opt: 592, E(): 5.1e-26, (46.55% identity FT in 219 aa overlap); O29244|AF1018 from Archaeoglobus FT fulgidus (228 aa), FASTA scores: opt: 580, E(): 2.4e-25, FT (42.4% identity in 210 aa overlap); P75831|YBJZ_ECOLI|B0879 FT from Escherichia coli strain K12 (648 aa), FASTA scores: FT opt: 555, E(): 1.3e-23, (39.65% identity in 232 aa FT overlap); etc. Also highly similar to FT O53618|Rv0073|MTV030.17 ABC-TRANSPORTER ATP-BINDING SUBUNIT FT from Mycobacterium tuberculosis (330 aa), FASTA scores: FT opt: 1782, E(): 4.7e-92, (83.65% identity in 330 aa FT overlap); etc. Shows some similarity to FT Q11040|YC81_MYCTU|MTCY50.01|Rv1281c|MT1318 HYPOTHETICAL ABC FT TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium FT tuberculosis (612 aa) (32.9 % identity in 234 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop), FT PS00211 ABC transporters family signature, and PS00889 FT Cyclic nucleotide-binding domain signature 2. BELONGS TO FT THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS)." FT /db_xref="GOA:P63401" FT /db_xref="HSSP:1L2T" FT /db_xref="InterPro:IPR018488" FT /db_xref="UniProtKB/Swiss-Prot:P63401" FT /protein_id="CAB01051.1" FT /translation="MGGLTISDLVVEYSSGGYAVRPIDGLSLDVAPGSLVILLGPSGCG FT KTTLLSCLGGILRPKSGSIKFDDVDITTLEGAALAKYRRDKVGIVFQAFNLVSSLTALE FT NVMVPLRAAGVSRAAARKRAEDLLIRVNLGERMKHRPGDMSGGQQQRVAVARAIALDPQ FT LILADEPTAHLDFIQVEEVLRLIRSLAQGDRVVVVATHDSRMLPLADRVLELMPAQVSP FT NQPPETVHVKAGEVLFEQSTMGDLIYVVSEGEFEIVRELADGGEELVKTAAPGDYFGEI FT GVLFHLPRSATVRARSDATAVGYTAQAFRERLGVTRVADLIEHRELASE" FT misc_feature 110423..110446 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 110735..110779 FT /note="PS00211 ABC transporters family signature" FT misc_feature 111137..111190 FT /note="PS00889 Cyclic nucleotide-binding domain signature FT 2" FT CDS 111575..113326 FT /transl_table=11 FT /locus_tag="Rv2565" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2565, (MTCY9C4.03c), len: 583 aa. Conserved FT hypothetical protein, similar in part to Q9A6C3|CC2171 FT HYPOTHETICAL PROTEIN from Caulobacter crescentus (610 aa), FT FASTA scores: opt: 765, E(): 2.8e-37, (32.15% identity in FT 575 aa overlap). C-terminus also highly similar to various FT bacterial proteins e.g. O34731|YLBK_BACSU HYPOTHETICAL 28.3 FT KDA PROTEIN from Bacillus subtilis (260 aa), FASTA scores: FT opt: 386, E(): 2.2e-15, (33.05% identity in 245 aa FT overlap); CAC45997|SMC01003 CONSERVED HYPOTHETICAL PROTEIN FT from Rhizobium meliloti (Sinorhizobium meliloti) (321 aa), FT FASTA scores: opt: 352, E(): 2.5e-13, (29.65% identity in FT 280 aa overlap); Q9K9Q8|BH2587 HYPOTHETICAL PROTEIN from FT Bacillus halodurans (275 aa), FASTA scores: opt: 334, E(): FT 2.5e-12, (33.7% identity in 175 aa overlap); etc. And shows FT similarity to C-terminal half of some eukaryotic proteins FT e.g. Q9R114|NTE NEUROPATHY TARGET ESTERASE HOMOLOG from Mus FT musculus (Mouse) (1327 aa), FASTA scores: opt: 411, E(): FT 2.7e-16, (24.45% identity in 626 aa overlap); O60859 FT NEUROPATHY TARGET ESTERASE from Homo sapiens (Human) (1327 FT aa), FASTA scores: opt: 410, E(): 3.1e-16, (24.1% identity FT in 627 aa overlap); Q9U969|SWS|CG2212 SWISS CHEESE PROTEIN FT from Drosophila melanogaster (Fruit fly) (1425 aa), FASTA FT scores: opt: 401, E(): 1.1e-15, (27.75% identity in 544 aa FT overlap); etc. Also shows strong similarity to C-terminal FT half of O05884|Z95121|Rv3239c|MTY20B11.14c HYPOTHETICAL FT 110.2 KDA PROTEIN from Mycobacterium tuberculosis (1048 FT aa), FASTA scores: opt: 648, E(): 3e-30, (36.55% identity FT in 572 aa overlap); and O69695|Rv3728|MTV025.076 PUTATIVE FT TWO-DOMAIN MEMBRANE PROTEIN from Mycobacterium tuberculosis FT (1065 aa), FASTA scores: opt: 643, E(): 6e-30, (34.3% FT identity in 595 aa overlap)." FT /db_xref="GOA:P0A642" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/Swiss-Prot:P0A642" FT /protein_id="CAB01050.1" FT /translation="MTTARRRPKRRGTDARTALRNVPILADIDDEQLERLATTVERRHV FT PANQWLFHAGEPADSIYIVDSGRFVAVAPEGHVFAEMASGDSIGDLGVIAGAARSAGVR FT ALRDGVVWRIAAETFTDMLEATPLLQSAMLRAMARMLRQSRPAKTARRPRVIGVVSNGD FT TAAAPMVDAIATSLDSHGRTAVIAPPVETTSAVQEYDELVEAFSETLDRAERSNDWVLV FT VADRGAGDLWRHYVSAQSDRLVVLVDQRYPPDAVDSLATQRPVHLITCLAEPDPSWWDR FT LAPVSHHPANSDGFGALARRIAGRSLGLVMAGGGARGLAHFGVYQELTEAGVVIDRFGG FT TSSGAIASAAFALGMDAGDAIAAAREFIAGSDPLGDYTIPISALTRGGRVDRLVQGFFG FT NTLIEHLPRGFFSVSADMITGDQIIHRRGSVSGAVRASISIPGLIPPVHNGEQLLVDGG FT LLNNLPANVMCADTDGEVICVDLRRTFVPSKGFGLLPPIVTPPGLLRRLLTGTDNALPP FT LQETLLRAFDLAASTANLRELPRVAAIIEPDVSKIGVLNFKQIDAALEAGRMAARAALQ FT AQPDLVR" FT CDS 113337..116759 FT /transl_table=11 FT /locus_tag="Rv2566" FT /product="LONG CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2566, (MTCY9C4.02c), len: 1140 aa. Long conserved FT hypothetical protein, equivalent to O53120|ML2678 OR FT MLCB1913.12 HYPOTHETICAL PROTEIN from Mycobacterium leprae FT (1000 aa), FASTA scores: opt: 760, E(): 7.1e-38, (50.2% FT identity in 1128 aa overlap); and middle part equivalent to FT Q9ZB40 72.2 KDA PROTEIN (FRAGMENT) from Mycobacterium FT leprae (644 aa), FASTA scores: opt: 1017, E(): 1.5e-65, FT (45.65% identity in 655 aa overlap). Also highly similar to FT Q98HG6|MLL2877 HYPOTHETICAL PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413, FT E(): 3.7e-77, (52.4% identity in 1148 aa overlap); and FT N-terminus shows similarity with other proteins e.g. FT Q9HUN8|PA4926 HYPOTHETICAL PROTEIN from Pseudomonas FT aeruginosa (311 aa), FASTA scores: opt: 278, E(): 3e-09, FT (29.95% identity in 284 aa overlap); and upstream ORF FT Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (314 FT aa), FASTA scores: opt: 252, E(): 1.1e-07, (28.9% identity FT in 315 aa overlap). Equivalent to AAK46955 from FT Mycobacterium tuberculosis strain CDC1551 (1156 aa) but FT shorter 16 aa." FT /db_xref="InterPro:IPR002931" FT /db_xref="UniProtKB/TrEMBL:Q50732" FT /protein_id="CAB01049.1" FT /translation="MPLRPTQVSGTGRTRCAGRSGVISSAAMSIKVALEHRTSYTFDRL FT VRVYPHIVRLRPAPHSRTSIEAYSLRIEPADHFINWQQDALGNFLARLVFPNPMRQLRI FT TVGLIADLKVINPFDFFIEDWAEIWPCAGMAYPKALADDLRPYLRPVDEDGDGSGPGEL FT TQAWVRNFTVPDGTRTIDFLVALNRAINADVGYCVRMEPGVQTPDFTLRTGVGSCRDSA FT WLLVSILRQFGLAARFVSGYLVQLASDIEALDGPSGPAADFTDLHAWAEAYIPGAGWIG FT LDPTSGLLAGEGHIPLAATPHPASAAPISGGTDVCDTVLEFSNTVTRVHEDPRVTLPYT FT DESWKTICEVGQRVDERLAAADVRLTVGGEPTFVSVDNQVAEEWRTAADGPHKRERASD FT LAARLKAVWAPQGLIHRGQGRWYPGEPLPRWQIALYWRTDGRPLWTNDALLADPWGAPP FT ADPVDDDAAYRVLAGIADGLGLPISQVRPAYEDPLSRLAAAVRMPAGDPVESGDDLGCD FT TNPDTPTGRAALLARLDEAITSPAAYVLPLHRRDDGQGWASANWRLRRGRIVLLEGDSP FT AGLRLPLDSISWRPPRASFDADPVAVRSTLPAELHTDRAVVEDPETAPTTALVAEVRGG FT LVHIFLPPTDALEHFIDLVARVEAAATTANCPVVIEGYGPPPDPRLTSTTITPDPGVIE FT VNIAPTASFAEQRQQLETLYQQARLARLTTEAFDVDGTHGGTGGGNHITLGGVTPADSP FT LLRRPDLLVSLLTYWQRHPSLSYLFAGRFVGTTSQAPRVDEGRAEALYELEIAFAEILR FT LSPSSGGGRPQPWVTDRALRHLLTDITGNTHRAEFCIDKLYSPDSARGRLGLLELRGFE FT MPPHLHMAMVQSLLVRSLVAWFWDQPLRAPLIRHGANLHGRYLLPHFLIHDIADVAADL FT RAHGIAFETSWLDPFTEFRFPRIGTAVFDGIEIELRGAIEPWHTLGEEATAAGTARYVD FT SSVERIQVRIIGADRHRYVVTCNGYPMPLLATDNPDIHVGGVRFKAWQPPSALHPTITV FT DGPLRFELIDIATATSCGGCTYHVAHPGGRAYDEPPVNAVEAEARRARRFEATGFTPGK FT LDLSDIREKQARISTDIGAPGILDLRRVRTVQQ" FT CDS 116759..119413 FT /transl_table=11 FT /locus_tag="Rv2567" FT /product="CONSERVED HYPOTHETICAL ALANINE AND LEUCINE RICH FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv2567, (MTCY227.34c, MTCY9C4.01c), len: 884 aa. FT Conserved hypothetical ala-, leu-rich protein, equivalent FT to O53121|ML2679|MLCB1913.13 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (893 aa), FASTA scores: opt: 4326, FT E(): 0, (75.2% identity in 883 aa overlap); and similar to FT Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 FT HYPOTHETICAL 61.8 KDA PROTEIN from Mycobacterium leprae FT (561 aa), FASTA scores: opt: 758, E(): 1.2e-38, (32.2% FT identity in 537 aa overlap). Also similar to others e.g. FT Q9HUN7|PA4927 HYPOTHETICAL PROTEIN from Pseudomonas FT aeruginosa (830 aa), FASTA scores: opt: 1247, E(): 2.2e-68, FT (38.25% identity in 831 aa overlap); Q98HG7|MLL2876 FT HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium FT loti) (803 aa), FASTA scores: opt: 937, E(): 1.9e-49, FT (32.15% identity in 828 aa overlap); CAC47419|SMC04057 FT CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti FT (Sinorhizobium meliloti) (802 aa), FASTA scores: opt: 900, FT E(): 3.4e-47, (30.85% identity in 852 aa overlap); etc. And FT similar to P71732|YO11_MYCTU|Rv2411c|MT2484|MTCY253.09 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (551 aa), FASTA scores: opt: 781, E(): FT 4.6e-40, (33.75% identity in 495 aa overlap)." FT /db_xref="InterPro:IPR007302" FT /db_xref="UniProtKB/Swiss-Prot:Q50654" FT /protein_id="CAB01053.1" FT /translation="MAPSASAATNGYDVDRLLAGYRTARAQETLFDLRDGPGAGYDEFV FT DDDGNVRPTWTELADAVAERGKAGLDRLRSVVHSLIDHDGITYTAIDAHRDALTGDHDL FT EPGPWRLDPLPLVISAADWEVLEAGLVQRSRLLDAILADLYGPRSMLTEGVLPPEMLFA FT HPGYVRAANGIQMPGRHQLFMHACDLSRLPDGTFQVNADWTQAPSGSGYAMADRRVVAH FT AVPDLYEELAPRPTTPFAQALRLALIDAAPDVAQDPVVVVLSPGIYSETAFDQAYLATL FT LGFPLVESADLVVRDGKLWMRSLGTLKRVDVVLRRVDAHYADPLDLRADSRLGVVGLVE FT AQHRGTVTVVNTLGSGILENPGLLRFLPQLSERLLDESPLLHTAPVYWGGIASERSHLL FT ANVSSLLIKSTVSGETLVGPTLSSAQLADLAVRIEAMPWQWVGQELPQFSSAPTNHAGV FT LSSAGVGMRLFTVAQRSGYAPMIGGLGYVLAPGPAAYTLKTVAAKDIWVRPTERAHAEV FT ITVPVLAPPAKTGAGTWAVSSPRVLSDLFWMGRYGERAENMARLLIVTRERYHVFRHQQ FT DTDESECVPVLMAALGKITGYDTATGAGSAYDRADMIAVAPSTLWSLTVDPDRPGSLVQ FT SVEGLALAAQAVRDQLSNDTWMVLANVERAVEHKSDPPQSLAEADAVLASAQAETLAGM FT LTLSGVAGESMVHDVGWTMMDIGKRIERGLWLTALLQATLSTVRHPAAEQAIIEATLVA FT CESSVIYRRRTVGKFSVAAVTELMLFDAQNPRSLVYQLERLRADLKDLPGSSGSSRPER FT MVDEMNTRLRRSHPEELEEVSADGLRAELAELLAGIHASLRDVADVLTATQLALPGGMQ FT PLWGPDQRRVMPA" FT CDS complement(119410..120435) FT /transl_table=11 FT /locus_tag="Rv2568c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2568c, (MTCY227.33), len: 341 aa. Conserved FT hypothetical protein, highly similar (but longer 60 aa) to FT Q98E75|MLR4376 HYPOTHETICAL PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (308 aa), FASTA scores: opt: 566, E(): FT 4.1e-29, (40.2% identity in 291 aa overlap)." FT /db_xref="InterPro:IPR011201" FT /db_xref="UniProtKB/Swiss-Prot:P65009" FT /protein_id="CAB01275.1" FT /translation="MRDFHCPNCGQRLAFENSACLSCGSALGFSLGRMALLVIADDADV FT QLCANLHLAQCNWLVPSDQLGGLCSSCVLTIERPSDTNTAGLAEFARAEGAKRRLIAEL FT HELKLPIVGRDQDPDHGLAFRLLSSAHENVTTGHQNGVITLDLAEGDDVHREQLRVEMD FT EPYRTLLGHFRHEIGHYYFYRLIASSSDYLSRFNELFGDPDADYSQALDRHYRGGPPEG FT WQDSFVSSYATMHASEDWAETFAHYLHIRDALDTAAWCGLAPASATFDRPALGPSAFNT FT IIDKWLPLSWSLNMVNRSMGHDDLYPFVLPAAVLEKMRFIHTVVDEVAPDFEPAHSRRT FT V" FT CDS complement(120428..121372) FT /transl_table=11 FT /locus_tag="Rv2569c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2569c, (MTCY227.32), len: 314 aa. Conserved FT hypothetical protein, equivalent to Q9CCT2|ML0508 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (313 aa), FT FASTA scores: opt: 1723, E(): 1.9e-95, (84.4% identity in FT 301 aa overlap); and some similarity with FT Q49757|YP69_MYCLE|ML0607|MLCL536.03c|B1937_F2_39 FT HYPOTHETICAL 31.1 KDA PROTEIN from Mycobacterium leprae FT (279 aa), FASTA scores: opt: 305, E(): 4.5e-11, (33.0% FT identity in 300 aa overlap). Also similar to to other FT hypothetical proteins e.g. Q9HUN8|PA4926 from Pseudomonas FT aeruginosa (311 aa), FASTA scores: opt: 704, E(): 8.7e-35, FT (39.7% identity in 320 aa overlap); Q98HG8|MLL2875 from FT Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA scores: FT opt: 521, E(): 6.5e-24, (35.05% identity in 294 aa FT overlap); Q9A7W9|CC1600 from Caulobacter crescentus (325 FT aa), FASTA scores: opt: 510, E(): 3.2e-23, (34.4% identity FT in 2588 aa overlap); etc. Also some similarity with FT proteins from Mycobacterium tuberculosis e.g. FT P71734|Rv2409c|MTCY253.11 CONSERVED HYPOTHETICAL PROTEIN FT (279 aa), FASTA scores: opt: 312, E(): 1.7e-11, (34.45% FT identity in 296 aa overlap); and Q50732|Rv2566|MTCY9C4.02 FT LONG CONSERVED HYPOTHETICAL PROTEIN (1140 aa), FASTA FT scores: opt: 252, E(): 2.2e-07, (28.9% identity in 315 aa FT overlap)" FT /db_xref="InterPro:IPR002931" FT /db_xref="UniProtKB/Swiss-Prot:P0A5G5" FT /protein_id="CAB01274.1" FT /translation="MSADSSLSLPLSGTHRYRVTHRTEYRYSDVVTSSYGRGFLTPRNS FT LRQRCVAHRLTIDPAPADRSTSRDGYGNISSYFHVTEPHRTLTITSDSIVDVSPPPPGL FT YTSGPALQPWEAARPAGLPGSLATEFTLDLNPPEITDAVREYAAPSFLPKRPLVEVLRD FT LASRIYTDFTYRSGSTTISTGVNEVLLAREGVCQDFARLAIACLRANGLAACYVSGYLA FT TDPPPGKDRMIGIDATHAWASVWTPQQPGRFEWLGLDPTNDQLVDQRYIVVGRGRDYAD FT VPPLRGIIYTNSENSVIDVSVDVVPFEGDALHA" FT CDS 121476..121865 FT /transl_table=11 FT /locus_tag="Rv2570" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2570, (MTCY227.31c), len: 129 aa. Conserved FT hypothetical protein, similar to Q98GQ7|MLR3218 FT HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium FT loti) (133 aa), FASTA scores: opt: 174, E(): 9.6e-05, FT (32.25% identity in 124 aa overlap); Q9A390|CC3314 FT HYPOTHETICAL PROTEIN from Caulobacter crescentus (129 aa), FT FASTA scores: opt: 155, E(): 0.0017, (33.35% identity in FT 108 aa overlap); and Q9A2Y0|CC3426 HYPOTHETICAL PROTEIN FT from Caulobacter crescentus (120 aa), FASTA scores: opt: FT 144, E(): 0.0083, (32.95% identity in 91 aa overlap)." FT /db_xref="InterPro:IPR007028" FT /db_xref="UniProtKB/Swiss-Prot:P65013" FT /protein_id="CAB01273.1" FT /translation="MATWDDVARIVGGLPLTAEQAPHDWRVGRKLLAWERPLRKSDREA FT LTRAGSEPPSGDIVGVRVSDEGVKFALIADEPGVYFTTPHFDGYPAVLVRLAEIEVRDL FT EELITEAWLMQAPKQLVQAFLANSG" FT CDS complement(121857..122924) FT /transl_table=11 FT /locus_tag="Rv2571c" FT /product="PROBABLE TRANSMEMBRANE ALANINE AND VALINE AND FT LEUCINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2571c, (MTCY227.30), len: 355 aa. Probable FT transmembrane ala-, val-, leu-rich protein, showing some FT similarity with other membrane proteins e.g. FT Q99340|YFDA_CORGL HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT from Corynebacterium glutamicum (Brevibacterium flavum) FT (359 aa), FASTA scores: opt: 338, E(): 2.5e-13, (29.4% FT identity in 255 aa overlap); Q9RD86|SCF43.02 PUTATIVE FT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (379 FT aa), FASTA scores: opt: 208, E(): 2.1e-05, (26.05% identity FT in 303 aa overlap); Q9RD81|SCF43.07 PUTATIVE INTEGRAL FT MEMBRANE PROTEIN from Streptomyces coelicolor (419 aa), FT FASTA scores: opt: 205, E(): 3.5e-05, (25.15% identity in FT 362 aa overlap); etc." FT /db_xref="GOA:P65015" FT /db_xref="UniProtKB/Swiss-Prot:P65015" FT /protein_id="CAB01272.1" FT /translation="MSASLLVRTACGGRAVAQRLRTVLWPITQTSVVAGLAWYLTHDVF FT NHPQAFFAPISAVVCMSATNVLRARRAQQMIVGVALGIVLGAGVHALLGSGPIAMGVVV FT FIALSVAVLCARGLVAQGLMFINQAAVSAVLVLVFASNGSVVFERLFDALVGGGLAIVF FT SILLFPPDPVVMLCSARADVLAAVRDILAELVNTVSDPTSAPPDWPMAAADRLHQQLNG FT LIEVRANAAMVARRAPRRWGVRSTVRDLDQQAVYLALLVSSVLHLARTIAGPGGDKLPT FT PVHAVLTDLAAGTGLADADPTAANEHAAAARATASTLQSAACGSNEVVRADIVQACVTD FT LQRVIERPGPSGMSA" FT CDS complement(122977..124767) FT /transl_table=11 FT /gene="aspS" FT /locus_tag="Rv2572c" FT /product="PROBABLE ASPARTYL-TRNA SYNTHETASE ASPS FT (ASPARTATE--TRNA LIGASE) (ASPRS) (ASPARTIC ACID TRANSLASE)" FT /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC FT ACTIVITY: ATP + L-ASPARTATE + TRNA(ASP) = AMP + FT PYROPHOSPHATE + L-ASPARTYL-TRNA(ASP)]." FT /EC_number="6.1.1.12" FT /note="Rv2572c, (MTCY227.29), len: 596 aa. Probable aspS, FT aspartyl-tRNA synthetase (EC 6.1.1.12), equivalent to FT P36429|SYD_MYCLE|ML0501|MLCB1259.19 ASPARTYL-TRNA FT SYNTHETASE from Mycobacterium leprae (589 aa), FASTA FT scores: opt: 3534, E(): 1.8e-215, (87.85% identity in 592 FT aa overlap). Also highly similar to many e.g. FT O67589|SYD_AQUAE|AQ_1677 from Aquifex aeolicus (603 aa), FT FASTA scores: opt: 1829, E(): 8.2e-108, (47.5% identity in FT 598 aa overlap); O32038|SYD_BACSU from Bacillus subtilis FT (592 aa), FASTA scores: opt: 1732, E(): 1.1e-101, (46.25% FT identity in 597 aa overlap); P21889|SYD_ECOLI|TLS|B1866 FT from Escherichia coli strain K12 (590 aa), FASTA scores: FT opt: 1588, E(): 1.3e-92, (47.35% identity in 581 aa FT overlap); etc. Contains PS00179 Aminoacyl-transfer RNA FT synthetases class-II signature 1. BELONGS TO CLASS-II FT AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:Q50649" FT /db_xref="HSSP:1L0W" FT /db_xref="InterPro:IPR004365" FT /db_xref="UniProtKB/Swiss-Prot:Q50649" FT /protein_id="CAB01271.1" FT /translation="MFVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDAS FT GIAQVVFRDPQDTEVLAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLT FT VLGECAPLPFQLDEPAGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHDFVE FT IETPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRD FT EDFRADRQPEFTQLDMEMSFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMR FT RFGTDKPDLRFGLELVECTDFFSDTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQDWAK FT QRGHRGLAYVLVAEDGTLGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRAL FT LGAARVEIANRLGLIDPDAWAFVWVVDPPLFEPADEATAAGEVAVGSGAWTAVHHAFTA FT PKPEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEE FT KFGFLLEAFMFGAPPHGGIAFGWDRTTALLAGMDSIREVIAFPKTGGGVDPLTDAPAPI FT TAQQRKESGIDAQPKRVQQA" FT misc_feature complement(124057..124110) FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT CDS 125007..125747 FT /transl_table=11 FT /locus_tag="Rv2573" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2573, (MTCY227.28c), len: 246 aa. Conserved FT hypothetical protein, similar to various proteins e.g. FT Q9ABG6|CC0261 HYPOTHETICAL PROTEIN from Caulobacter FT crescentus (290 aa), FASTA scores: opt: 516, E(): 5.8e-26, FT (40.1% identity in 237 aa overlap); Q99R37|SA2393 FT HYPOTHETICAL PROTEIN (similar to 2-dehydropantoate FT 2-reductase) from Staphylococcus aureus subsp. aureus N315 FT (286 aa), FASTA scores: opt: 368, E(): 1.8e-16, (31.75% FT identity in 230 aa overlap); Q9KPQ9|VC2307 FT 2-DEHYDROPANTOATE 2-REDUCTASE from Vibrio cholerae (296 FT aa), FASTA scores: opt: 223, E(): 3.9e-07, (27.7% identity FT in 224 aa overlap); etc. Equivalent to AAK46962 from FT Mycobacterium tuberculosis strain CDC1551 (275 aa) but FT shorter 29 aa." FT /db_xref="GOA:Q50648" FT /db_xref="InterPro:IPR013328" FT /db_xref="UniProtKB/Swiss-Prot:Q50648" FT /protein_id="CAB01270.1" FT /translation="MVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTV FT VAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQF FT AGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRYVAE FT CLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRKAR FT AHGLATPISDVLVPLLAAASDGPG" FT CDS 125770..126273 FT /transl_table=11 FT /locus_tag="Rv2574" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2574, (MTCY227.27c), len: 167 aa. Conserved FT hypothetical protein, showing similarity with FT Q9K3N3|SCG20A.07 HYPOTHETICAL 17.4 KDA PROTEIN from FT Streptomyces coelicolor (157 aa), FASTA scores: opt: 218, FT E(): 2.8e-08, (30.65% identity in 150 aa overlap)." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/Swiss-Prot:P65017" FT /protein_id="CAB01269.1" FT /translation="MYPCERVGLSFTETAPYLFRNTVDLAITPEQLFEVLADPQAWPRW FT ATVITKVTWTSPEPFGAGTTRIVEMRGGIVGDEEFISWEPFTRMAFRFNECSTRAVGAF FT AEDYRVQAIPGGCRLTWTMAQKLAGPARPALFVFRPLLNLALRRFLRNLRRYTDARFAA FT AQQS" FT CDS 126303..127184 FT /transl_table=11 FT /locus_tag="Rv2575" FT /product="POSSIBLE CONSERVED MEMBRANE GLYCINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2575, (MTCY227.26c), len: 293 aa. Possible FT conserved membrane gly-rich protein, highly similar to FT hypothetical proteins e.g. Q9RR98|DR2596 CONSERVED FT HYPOTHETICAL PROTEIN from Deinococcus radiodurans (313 aa), FT FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in FT 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa FT (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% FT identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium FT loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628, FT E(): 1e-31, (38.45% identity in 307 aa overlap); etc. FT Contains PS00142 Neutral zinc metallopeptidases, FT zinc-binding region signature." FT /db_xref="GOA:P65019" FT /db_xref="InterPro:IPR007343" FT /db_xref="UniProtKB/Swiss-Prot:P65019" FT /protein_id="CAB01268.1" FT /translation="MTFNEGVQIDTSTTSTSGSGGGRRLAIGGGLGGLLVVVVAMLLGV FT DPGGVLSQQPLDTRDHVAPGFDLSQCRTGADANRFVQCRVVATGNSVDAVWKPLLPGYT FT RPHMRLFSGQVGTGCGPASSEVGPFYCPVDKTAYFDTDFFQVLVTQFGSSGGPFAEEYV FT VAHEYGHHVQNLLGVLGRAQQGAQGAAGSGVRTELQADCYAGVWAYYASTVKQESTGVP FT YLEPLSDKDIQDALAAAAAVGDDRIQQQTTGRTNPETWTHGSAAQRQKWFTVGYQTGDP FT NICDTFSAADLG" FT misc_feature 126789..126818 FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS complement(127190..127654) FT /transl_table=11 FT /locus_tag="Rv2576c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2576c, (MTCY227.25), len: 154 aa. Possible FT conserved membrane protein, showing similarity with Q9ZFC2 FT HYPOTHETICAL 15.7 KDA PROTEIN from Mycobacterium sp. FM10 FT (146 aa), FASTA scores: opt: 235, E(): 4.1e-08, (31.35% FT identity in 150 aa overlap)." FT /db_xref="GOA:P65021" FT /db_xref="InterPro:IPR016793" FT /db_xref="UniProtKB/Swiss-Prot:P65021" FT /protein_id="CAB01267.1" FT /translation="MPAGVGNASGSVLDMTSVRTVPSAVALVTFAGAALSGVIPAIARA FT DPVGHQVTYTVTTTSDLMANIRYMSADPPSMAAFNADSSKYMITLHTPIAGGQPLVYTA FT TLANPSQWAIVTASGGLRVNPEFHCEIVVDGQVVVSQDGGSGVQCSTRPW" FT CDS 127882..129471 FT /transl_table=11 FT /locus_tag="Rv2577" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2577, (MTCY227.24c), len: 529 aa. Conserved FT hypothetical protein, showing similarity with various FT proteins from eukaryotes, in particular phosphatases, e.g. FT Q9SE01|PAP PURPLE ACID PHOSPHATASE PRECURSOR (EC 3.1.3.2) FT from Glycine max (Soybean) (464 aa), FASTA scores: opt: FT 190, E(): 0.00026, (27.3% identity in 388 aa overlap); FT Q9SVP2|F18A5.90|AT4G13700 HYPOTHETICAL 53.4 KDA PROTEIN FT from Arabidopsis thaliana (Mouse-ear cress) (474 aa), FASTA FT scores: opt: 280, E(): 6.6e-10, (27.2% identity in 331 aa FT overlap); Q9FK32 SIMILARITY TO UNKNOWN PROTEIN from FT Arabidopsis thaliana (Mouse-ear cress) (529 aa), FASTA FT scores: opt: 249, E(): 6.2e-08, (25.3% identity in 435 aa FT overlap); Q12546|APHA ACID PHOSPHATASE PRECURSOR from FT Aspergillus ficuum (614 aa), FASTA scores: opt: 207, E(): FT 2.9e-05, (22.95% identity in 458 aa overlap); etc." FT /db_xref="GOA:Q50644" FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/Swiss-Prot:Q50644" FT /protein_id="CAB01266.1" FT /translation="MGADLKQPQDADSPPKGVSRRRFLTTGAAAVVGTGVGAGGTALLS FT SHPRGPAVWYQRGRSGAPPVGGLHLQFGRNASTEMVVSWHTTDTVGNPRVMLGTPTSGF FT GSVVVAETRSYRDAKSNTEVRVNHAHLTNLTPDTDYVYAAVHDGTTPELGTARTAPSGR FT KPLRFTSFGDQSTPALGRLADGRYVSDNIGSPFAGDITIAIERIAPLFNLINGDLCYAN FT LAQDRIRTWSDWFDNNTRSARYRPWMPAAGNHENEVGNGPIGYDAYQTYFAVPDSGSSP FT QLRGLWYSFTAGSVRVISLHNDDVCYQDGGNSYVRGYSGGEQRRWLQAELANARRDSEI FT DWVVVCMHQTAISTADDNNGADLGIRQEWLPLFDQYQVDLVVCGHEHHYERSHPLRGAL FT GTDTRTPIPVDTRSDLIDSTRGTVHLVIGGGGTSKPTNALLFPQPRCQVITGVGDFDPA FT IRRKPSIFVLEDAPWSAFRDRDNPYGFVAFDVDPGQPGGTTSIKATYYAVTGPFGGLTV FT IDQFTLTKPRGG" FT CDS complement(129473..130495) FT /transl_table=11 FT /locus_tag="Rv2578c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN. THOUGHT TO BE REGULATED BY FT Rv2720|LEXA." FT /note="Rv2578c, (MTCY227.23), len: 340 aa. Conserved FT hypothetical protein, highly similar to hypothetical FT proteins (conserved or not) e.g. Q9ZBJ3|SC9C7.17c from FT Streptomyces coelicolor (348 aa), FASTA scores: opt: 998, FT E(): 1.6e-55, (47.6% identity in 355 aa overlap); FT Q9I763|PA0069 from Pseudomonas aeruginosa (352 aa), FASTA FT scores: opt: 560, E(): 6e-28, (36.6% identity in 284 aa FT overlap); Q986C9|MLL7417 from Rhizobium loti (Mesorhizobium FT loti) (356 aa), FASTA scores: opt: 550, E(): 2.6e-27, FT (39.15% identity in 240 aa overlap); etc." FT /db_xref="GOA:P65023" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/Swiss-Prot:P65023" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01265.1" FT /translation="MRWARQAVAVNGMPVDDGALPGLQRIGLVRSVRAPQFDGITFHEV FT LCKSALNKVPNAAALPFRYTVNGYRGCSHACRYCFARPTHEYLDFNPGTDFDTQVVVKT FT NVAAVLRHELRRPSWRRETVALGTNTDPYQRAEGRYALMPGIIGALAASGTPLSILTKG FT TLLRRDLPLIAEAAQQVPVSVAVSLAVGDPELHRDVESGTPTPQARLALITAIRAAGLD FT CHVMVAPVLPQLTDSGEHLDQLLGQIAAAGATGVTVFGLHLRGSTRGWFMCWLARAHPE FT LVSRYRELYRRGPYLPPSYREMLRERVAPLIAKYRLAGDHRPAPPETEAALVPVQATLF FT " FT CDS 130603..131505 FT /transl_table=11 FT /gene="dhaA" FT /locus_tag="Rv2579" FT /standard_name="linB" FT /product="POSSIBLE HALOALKANE DEHALOGENASE DHAA FT (1-CHLOROHEXANE HALIDOHYDROLASE)" FT /function="GENERATES A PRIMARY ALCOHOL AND HALIDE FROM FT 1-HALOALKANE AND H2O [CATALYTIC ACTIVITY: 1-HALOALKANE + FT H2O = A PRIMARY ALCOHOL + HALIDE]. THOUGHT TO BE REGULATED FT BY Rv2720|LEXA." FT /EC_number="3.8.1.5" FT /note="Rv2579, (MTCY227.22c), len: 300 aa. Possible dhaA, FT haloalkane dehalogenase (EC 3.8.1.5), strictly equivalent FT to Q9XB14|ISO-RV2579 HALOALKANE DEHALOGENASE FT (1-chlorohexane halidohydrolase) (EC 3.8.1.5) from FT Mycobacterium bovis (300 aa), FASTA scores: opt: 2075, E(): FT 7.1e-125, (99.35% identity in 300 aa overlap); note that FT only two residues, 120 and 293 are different. Also highly FT similar to others e.g. Q9ZER0|DHAAF HALOALKANE DEHALOGENASE FT from Mycobacterium sp strain GP1 (307 aa), FASTA scores: FT opt: 842, E(): 2.3e-46, (44.95% identity in 298 aa FT overlap); Q53042|DHAA HALOALKANE DEHALOGENASE from FT Rhodococcus rhodochrous, and Pseudomonas pavonaceae (293 FT aa), FASTA scores: opt: 837, E(): 4.5e-46, (44.6% identity FT in 298 aa overlap); etc. Note that this protein may also be FT a 1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase (EC FT 3.8.1.-), because also highly similar to P51698|LINB_PSEPA FT 1,3,4,6-TETRACHLORO-1,4-CYCLOHEXADIENE HYDROLASE from FT Pseudomonas paucimobilis (Sphingomonas paucimobilis) (see FT Nagata et al., 1993) (296 aa), FASTA scores: opt: 1494, FT E(): 6.8e-88, (69.5% identity in 295 aa overlap). Also FT shows some similarity with proteins from Mycobacterium FT tuberculosis e.g. FT Q50670|YM96_MYCTU|Rv2296|MT2353|MTCY339.14c PUTATIVE FT HALOALKANE DEHALOGENASE (300 aa), FASTA scores: opt: 302, FT E(): 5.3e-12, (30.85% identity in 295 aa overlap); and FT Q50600|YJ33_MYCTU|Rv1833c|MT1881|MTCY1A11.10 HYPOTHETICAL FT 32.2 KDA PROTEIN (286 aa), FASTA scores: opt: 286, E(): FT 5.3e-11, (29.85% identity in 288 aa overlap). MAY BE BELONG FT TO ALPHA/BETA HYDROLASE FOLD FAMILY. Note that previously FT known as linB." FT /db_xref="GOA:Q50642" FT /db_xref="InterPro:IPR000639" FT /db_xref="PDB:2O2H" FT /db_xref="UniProtKB/Swiss-Prot:Q50642" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55500.1" FT /translation="MTAFGVEPYGQPKYLEIAGKRMAYIDEGKGDAIVFQHGNPTSSYL FT WRNIMPHLEGLGRLVACDLIGMGASDKLSPSGPDRYSYGEQRDFLFALWDALDLGDHVV FT LVLHDWGSALGFDWANQHRDRVQGIAFMEAIVTPMTWADWPPAVRGVFQGFRSPQGEPM FT ALEHNIFVERVLPGAILRQLSDEEMNHYRRPFVNGGEDRRPTLSWPRNLPIDGEPAEVV FT ALVNEYRSWLEETDMPKLFINAEPGAIITGRIRDYVRSWPNQTEITVPGVHFVQEDSPE FT EIGAAIAQFVRRLRSAAGV" FT CDS complement(131785..133056) FT /transl_table=11 FT /gene="hisS" FT /locus_tag="Rv2580c" FT /product="PROBABLE HISTIDYL-TRNA SYNTHETASE HISS FT (HISTIDINE--TRNA LIGASE) (HISRS) (HISTIDINE--TRANSLASE)" FT /function="INVOLVED IN TRANSLATION MECHAMISM [CATALYTIC FT ACTIVITY: ATP + L-HISTIDINE + TRNA(HIS) = AMP + FT PYROPHOSPHATE + L-HISTIDYL-TRNA(HIS)]." FT /EC_number="6.1.1.21" FT /note="Rv2580c, (MT2657, MTCY227.21), len: 423 aa. Probable FT hisS, histidyl-tRNA synthetase (EC 6.1.1.21), equivalent to FT P46696|SYH_MYCLE|HISS|ML0494|MLCB1259.12|B1177_C3_248 FT HISTIDYL-TRNA SYNTHETASE from Mycobacterium leprae (427 FT aa), FASTA scores: opt: 2380, E(): 2.1e-131, (85.85% FT identity in 417 aa overlap). Also highly similar to many FT e.g. Q9KXP2|HISS from Streptomyces coelicolor (425 aa), FT FASTA scores: opt: 1542, E(): 1.4e-82, (56.0% identity in FT 418 aa overlap); O32422|SYH_STAAU|HISS from Staphylococcus FT aureus (420 aa), FASTA scores: opt: 1135, E(): 7.4e-59, FT (44.9% identity in 412 aa overlap); FT P04804|SYH_ECOLI|HISS|B2514 from Escherichia coli strain FT K12 (423 aa), FASTA scores: opt: 1099, E(): 9.4e-57, (43.9% FT identity in 417 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO CLASS-II FT AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:P67483" FT /db_xref="HSSP:1QE0" FT /db_xref="InterPro:IPR004516" FT /db_xref="UniProtKB/Swiss-Prot:P67483" FT /protein_id="CAB01263.1" FT /translation="MTEFSSFSAPKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIEL FT PIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGAL FT PVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGLDGF FT RLEITSLGDESCRPQYRELLQEFLFGLDLDEDTRRRAGINPLRVLDDKRPELRAMTASA FT PVLLDHLSDVAKQHFDTVLAHLDALGVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSG FT IGGGGRYDGLMHQLGGQDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAA FT KLRLAVLAGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAVKD FT LTTGEQVSVSMDSVVAEVISRLAG" FT misc_feature complement(132091..132114) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(133053..133727) FT /transl_table=11 FT /locus_tag="Rv2581c" FT /product="POSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE FT HYDROLASE) (GLX II)" FT /function="INVOLVED IN GLYOXAL PATHWAY. THIOLESTERASE THAT FT CATALYZES THE HYDROLYSIS OF S-D-LACTOYL-GLUTATHIONE TO FORM FT GLUTATHIONE AND D-LACTIC ACID [CATALYTIC ACTIVITY: FT (S)-(2-HYDROXYACYL)GLUTATHIONE + H(2)O = GLUTATHIONE + A FT 2-HYDROXY ACID ANION]." FT /EC_number="3.1.2.6" FT /note="Rv2581c, (MTCY227.20), len: 224 aa. Possible FT glyoxalase II (EC 3.1.2.6), equivalent to FT Q49649|YP81_MYCLE|ML0493|MLCB1259.11|B1177_C3_247 FT HYPOTHETICAL 23.9 KDA PROTEIN from Mycobacterium leprae FT (218 aa), FASTA scores: opt: 1264, E(): 7.8e-73, (82.0% FT identity in 222 aa overlap). Also highly similar to FT Q9KXP1|SC9C5.33c POSSIBLE HYDROLASE from Streptomyces FT coelicolor (235 aa), FASTA scores: opt: 654, E(): 2.9e-34, FT (46.8% identity in 220 aa overlap); and similar to FT Q9CI24|YFCI HYPOTHETICAL PROTEIN from Lactococcus lactis FT (subsp. lactis) (Streptococcus lactis) (210 aa), FASTA FT scores: opt: 360, E(): 9.9e-16, (35.0% identity in 217 aa FT overlap); AAK75726|SP1646 METALLO-BETA-LACTAMASE FT SUPERFAMILY PROTEIN from Streptococcus pneumoniae (209 aa), FT FASTA scores: opt: 320, E(): 3.3e-13, (35.85% identity in FT 198 aa overlap); AAK80229|CAC2272 PREDICTED ZN-DEPENDENT FT HYDROLASE OF METALLO-BETA-LACTAMASE SUPERFAMILY from FT Clostridium acetobutylicum (199 aa), FASTA scores: opt: FT 282, E(): 8e-11, (32.7% identity in 217 aa overlap); etc. FT Equivalent to AAK46971 from Mycobacterium tuberculosis FT strain CDC1551 (246 aa) but shorter 22 aa. BELONGS TO THE FT GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS." FT /db_xref="GOA:P64261" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/Swiss-Prot:P64261" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01262.1" FT /translation="MLITGFPAGLLACNCYVLAERPGTDAVIVDPGQGAMGTLRRILDK FT NRLTPAAVLLTHGHIDHIWSAQKVSDTFGCPTYVHPADRFMLTDPIYGLGPRIAQLVAG FT AFFREPKQVVELDRDGDKIDLGGISVNIDHTPGHTRGSVVFRVLQATNNDKDIVFTGDT FT LFERAIGRTDLAGGSGRDLLRSIVDKLLVLDDSTVVLPGHGNSTTIGAERRFNPFLEGL FT SR" FT CDS 133778..134704 FT /transl_table=11 FT /gene="ppiB" FT /locus_tag="Rv2582" FT /standard_name="ppi" FT /product="PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B FT PPIB (CYCLOPHILIN) (PPIASE) (ROTAMASE) (PEPTIDYLPROLYL FT ISOMERASE)" FT /function="PPIASES ACCELERATE THE FOLDING OF PROTEINS FT [CATALYTIC ACTIVITY: CIS-TRANS ISOMERIZATION OF PROLINE FT IMIDIC PEPTIDE BONDS INOLIGOPEPTIDES]." FT /EC_number="5.2.1.8" FT /note="Rv2582, (MTCY227.19c), len: 308 aa. Probable ppiB FT (alternate gene name: ppi), cyclophilin (peptidyl-prolyl FT cis-trans isomerase) (EC 5.2.1.8), equivalent to FT P46697|PPIB_MYCLE|PPI|ML0492|MLCB1259.10c|B1177_F3_97 FT PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B from FT Mycobacterium leprae (295 aa), FASTA scores: opt: 1423, FT E(): 1.3e-66, (72.2% identity in 295 aa overlap). Aldo FT similar to others e.g. Q9KJG8|PPIB PEPTIDYL-PROLYL FT CIS-TRANS ISOMERASE from Streptomyces lividans (277 aa), FT FASTA scores: opt: 485, E(): 3.2e-18, (38.35% identity in FT 292 aa overlap); Q9KXP0|SC9C5.34 PEPTIDYL-PROLYL CIS-TRANS FT ISOMERASE from Streptomyces coelicolor (277 aa), FASTA FT scores: opt: 483, E(): 4.1e-18, (38.35% identity in 292 aa FT overlap); Q9RT72|DR1893 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FT from Deinococcus radiodurans (350 aa), FASTA scores: opt: FT 296, E(): 2.2e-08, (29.0% identity in 276 aa overlap); etc. FT BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY." FT /db_xref="GOA:Q50639" FT /db_xref="HSSP:1A58" FT /db_xref="InterPro:IPR002130" FT /db_xref="UniProtKB/Swiss-Prot:Q50639" FT /protein_id="CAB01261.1" FT /translation="MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRR FT RILTIVGGSLAAVAVIVAVVVTVVVNKDDHQSTTSATPTDSASTSPPQAATAPPLPPFK FT PSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPC FT TVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSA FT NDPKLNEPVIYPRGTLAMANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDK FT IAKAGVAGGGEDGKPATEVTITSVLLD" FT CDS complement(134790..137162) FT /transl_table=11 FT /gene="relA" FT /locus_tag="Rv2583c" FT /product="PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP FT 3'-PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP FT SYNTHETASE) (GTP DIPHOSPHOKINASE)" FT /function="INVOLVED IN THE METABOLISM OF PPGPP (AT THE FT FIRST STEP). IN EUBACTERIA PPGPP (GUANOSINE 3'-DIPHOSPHATE FT 5-'DIPHOSPHATE) IS A MEDIATOR OF THE STRINGENT RESPONSE FT THAT COORDINATES A VARIETY OF CELLULAR ACTIVITIES IN FT RESPONSE TO CHANGES IN NUTRITIONAL ABUNDANCE. THIS ENZYME FT CATALYZES THE FORMATION OF PPPGPP WHICH IS THEN HYDROLYSED FT TO FORM PPGPP [CATALYTIC ACTIVITY: ATP + GTP = AMP + FT GUANOSINE 3'-DIPHOSPHATE 5-'TRIPHOSPHATE]." FT /EC_number="2.7.6.5" FT /note="Rv2583c, (MTCY227.18), len: 790 aa. Probable relA, FT GTP pyrophosphokinase (EC 2.7.6.5), equivalent to FT Q49640|RELA_MYCLE|ML0491|MLCB1259.09|B1177_C1_168 PROBABLE FT GTP PYROPHOSPHOKINASE from Mycobacterium leprae (787 aa), FT FASTA scores: opt: 4834, E(): 0, (93.4% identity in 790 aa FT overlap). Also highly similar to others e.g. FT O87331|RELA_CORGL|RELA|REL from Corynebacterium glutamicum FT (Brevibacterium flavum) (760 aa), FASTA scores: opt: 3375, FT E(): 1.6e-196, (67.0% identity in 758 aa overlap); FT O85709|RELA_STRAT from Streptomyces antibioticus (841 aa), FT FASTA scores: opt: 3209, E(): 1.9e-186, (63.85% identity in FT 786 aa overlap); Q9KDH1|RELA|BH1242 from Bacillus FT halodurans (728 aa), FASTA scores: opt: 2195,E(): 3.8e-125, FT (45.65% identity in 714 aa overlap); etc. BELONGS TO THE FT RELA / SPOT FAMILY." FT /db_xref="GOA:P66014" FT /db_xref="InterPro:IPR004095" FT /db_xref="UniProtKB/Swiss-Prot:P66014" FT /protein_id="CAB01260.1" FT /translation="MAEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRV FT RARLARRMTAQRSTTNPVLEPLVAVHREIYPKADLSILQRAYEVADQRHASQLRQSGDP FT YITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGVTKL FT DRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLE FT VIAPLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNT FT LTASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAAVGVVHS FT LWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRY FT KEAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPK FT GDVITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNA FT GPSRDWQQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREVRRGGLPLQRLVNGESM FT AAVARELHYADVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRR FT PRSTDDVGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQ FT AERIIEVLWAPSPSSVFLVAIQVEALDRHRLLSDVTRALADEKVNILSASVTTSGDRVA FT ISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA" FT CDS complement(137193..137864) FT /transl_table=11 FT /gene="apt" FT /locus_tag="Rv2584c" FT /product="ADENINE PHOSPHORIBOSYLTRANSFERASE APT (APRT) (AMP FT DIPHOSPHORYLASE) (AMP PYROPHOSPHORYLASE) FT (TRANSPHOSPHORIBOSIDASE)" FT /function="INVOLVED IN PURINE SALVAGE. CATALYSES A SALVAGE FT REACTION RESULTING IN THE FORMATION OF AMP, THAT IS FT ENERGICALLY LESS COSTLY THAN DE NOVO SYNTHESIS [CATALYTIC FT ACTIVITY: AMP + PYROPHOSPHATE = ADENINE + FT 5-PHOSPHO-ALPHA-D-RIBOSE 1-DIPHOSPHATE]." FT /EC_number="2.4.2.7" FT /note="Rv2584c, (MTCY227.17), len: 223 aa. Probable apt, FT adenine phosphoribosyltransferase (EC 2.4.2.7), similar, FT but longer in N-terminus, to others e.g. O87330|APT_CORGL FT from Corynebacterium glutamicum (Brevibacterium flavum) FT (185 aa), FASTA scores: opt: 524, E(): 1.3e-24, (50.95% FT identity in 159 aa overlap); P52561|APT_STRCO from FT Streptomyces coelicolor (182 aa), FASTA scores: opt: 503, FT E(): 2.3e-23, (51.85% identity in 164 aa overlap); FT P47956|APT_MUSPA|APRT from Mus pahari (Shrew mouse) (180 FT aa), FASTA scores: opt: 419, E(): 2.5e-18, (44.7% identity FT in 170 aa overlap); P07672|P09993|P77121|APT_ECOLI|B0469 FT from Escherichia coli strain K12 (183 aa), FASTA scores: FT opt: 393, E(): 1.9e-18, (42.6% identity in 162 aa overlap); FT etc. Contains PS00103 Purine/ pyrimidine phosphoribosyl FT transferases signature, and PS00144 Asparaginase / FT glutaminase active site signature 1. BELONGS TO THE FT PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FAMILY. Nearest FT initiation codon indicated by homology is TTG at 17426 or FT GTG at 17465." FT /db_xref="GOA:Q50637" FT /db_xref="HSSP:1G2P" FT /db_xref="InterPro:IPR000836" FT /db_xref="UniProtKB/Swiss-Prot:Q50637" FT /protein_id="CAB01259.1" FT /translation="MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGES FT RRSSAISVADVVASLTRDVADFPVPGVEFKDLTPLFADRRGLAAVTEALADRASGADLV FT AGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYRAYGAATLEILAEGIEVA FT GRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSR FT L" FT misc_feature complement(137322..137348) FT /note="PS00144 Asparaginase / glutaminase active site FT signature 1" FT misc_feature complement(137328..137366) FT /note="PS00103 Purine/pyrimidine phosphoribosyl FT transferases signature" FT CDS complement(137968..139641) FT /transl_table=11 FT /locus_tag="Rv2585c" FT /product="POSSIBLE CONSERVED LIPOPROTEIN" FT /function="UNKNOWN" FT /note="Rv2585c, (MT2662, MTCY227.16), len: 557 aa. Possible FT conserved lipoprotein precursor, possibly attached to the FT membrane by a lipid anchor and substrate-binding protein FT involved in transport, equivalent to FT Q49646|YP85_MYCLE|ML0489|MLCB1259.07|B1177_C2_197 FT HYPOTHETICAL LIPOPROTEIN PRECURSOR from Mycobacterium FT leprae (555 aa), FASTA scores: opt: 2812, E(): 9.8e-158, FT (78.95% identity in 546 aa overlap); and C-terminus highly FT similar to C-terminus of Q49638|DCIAE|B1177_C1_166 DCIAE FT PROTEIN from Mycobacterium leprae (344 aa), FASTA scores: FT opt: 1177, E(): 7.4e-62, (78.6% identity in 229 aa FT overlap). Also similar in part to various proteins, FT principally substrate-binding proteins, e.g. O87329|DCIAE FT DIPEPTIDE-BINDING PROTEIN from Corynebacterium glutamicum FT (Brevibacterium flavum) (502 aa), FASTA scores: opt: 614, FT E(): 1.2e-28, (30.7% identity in 427 aa overlap); FT Q9AKR0|OPPA|CAC49261 PUTATIVE OLIGOPEPTIDE UPTAKE ABC FT TRANSPORTER PERIPLASMIC SOLUTE-BINDING PROTEIN PRECURSOR FT from Rhizobium meliloti (Sinorhizobium meliloti) (532 aa), FT FASTA scores: opt: 209, E(): 7.7e-05, (22.85% identity in FT 460 aa overlap); P76128|YDDS_ECOLI|B1487|P77769|P76874 FT PUTATIVE ABC TRANSPORTER PERIPLASMIC BINDING PROTEIN from FT Escherichia coli strain K12 (516 aa), FASTA scores: opt: FT 182, E(): 0.0029, (20.0% identity in 315 aa overlap); etc." FT /db_xref="GOA:Q50636" FT /db_xref="InterPro:IPR000914" FT /db_xref="UniProtKB/Swiss-Prot:Q50636" FT /protein_id="CAB01258.1" FT /translation="MAPRRRRHTRIAGLRVVGTATLVAATTLTACSGSAAAQIDYVVDG FT ALVTYNTNTVIGAASAGAQAFARTLTGFGYHGPDGQVVADRDFGTVSVVEGSPLILDYQ FT ISDDAVYSDGRPVTCDDLVLAWAAQSGRFPGFDAATQAGYVDIANIECTAGQKKARVSF FT IPDRSVVDHSQLFTATSLMPSHVIADQLHIDVTAALLSNNVSAVEQIARLWNSTWDLKP FT GRSHDEVRSRFPSSGPYKIESVLDDGAVVLVANDRWWGTKAITKRITVWPQGADIQDRV FT NNRSVDVVDVAAGSSGSLVTPDSYQRTDYPSAGIEQLIFAPQGSLAQSRTRRALALCVP FT RDAIARDAGVPIANSRLSPATDDALTDADGAAEARQFGRVDPAAARDALGGTPLTVRIG FT YGRPNARLAATIGTIADACAPAGITVSDVTVDTPGPQALRDGKIDVLLASTGGATGSGS FT SGSCAMDAYDLHSGNGNNLSGYANAQIDGIISALAVSADPAERARLLAEAAPVLWDEMP FT TLPLYRQQRTLLMSTKMYAVSRNPTRWGAGWNMDRWALAR" FT CDS complement(139647..140975) FT /transl_table=11 FT /gene="secF" FT /locus_tag="Rv2586c" FT /product="PROBABLE PROTEIN-EXPORT MEMBRANE PROTEIN SECF" FT /function="INVOLVED IN PROTEIN EXPORT. PART OF THE FT PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE FT SECA, SECB, SECD, SECE, SECF, SECG AND SECY." FT /note="Rv2586c, (MT2663, MTCY227.15), len: 442 aa. Probable FT secF, protein-export membrane protein (integral membrane FT protein) (see citation below), equivalent to FT P38386|SECF_MYCLE|SECF|ML0488|MLCB1259.06|B1177_C3_239 FT PROTEIN-EXPORT MEMBRANE PROTEIN from Mycobacterium leprae FT (471 aa), FASTA scores: opt: 1910, E(): 2.9e-104, (72.15% FT identity in 456 aa overlap). Also similar to others e.g. FT Q9AE06|SECF from Corynebacterium glutamicum (Brevibacterium FT flavum) (403 aa), FASTA scores: opt: 1198, E(): 9.8e-63, FT (47.1% identity in 399 aa overlap); FT Q53956|SECF_STRCO|SCL2.05c from Streptomyces coelicolor FT (373 aa), FASTA scores: opt: 670, E(): 6.4e-32, (39.25% FT identity in 400 aa overlap); Q55611|SECF_SYNY3|SLR0775 from FT Synechocystis sp. strain PCC 6803 (315 aa), FASTA scores: FT opt: 416, E(): 3.8e-17, (33.8% identity in 296 aa overlap); FT etc. BELONGS TO THE SECD/SECF FAMILY, SECF FAMILY. PART OF FT THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH FT COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF, FT SECG|Rv1440 AND SECY|Rv0732." FT /db_xref="GOA:Q50635" FT /db_xref="InterPro:IPR005665" FT /db_xref="UniProtKB/Swiss-Prot:Q50635" FT /protein_id="CAB01257.1" FT /translation="MASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHH FT SFLSRLYTGTGAFEVVGRRRLWFGVSGAIVAVAIASIVFRGFTFGIDFKGGTTVSFPRG FT STQVAQVEDVYYRALGSEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAFGPK FT GTDGQPSKQAISDSAVSETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAM FT LFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTF FT AEQANLAINQTFMRSINTSLIGVLPVLALMVVAVWLLGVGTLKDLALVQLIGIIIGTYS FT SIFFATPLLVTLRERTELVRNHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVG FT ITQASSQSAPRAAQGSSKPAPGARPVRPVGTRRPTGKRNAGRR" FT CDS complement(140979..142700) FT /transl_table=11 FT /gene="secD" FT /locus_tag="Rv2587c" FT /product="PROBABLE PROTEIN-EXPORT MEMBRANE PROTEIN SECD" FT /function="INVOLVED IN PROTEIN EXPORT. PART OF THE FT PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE FT SECA, SECB, SECD, SECE, SECF, SECG AND SECY." FT /note="Rv2587c, (MTCY227.14), len: 573 aa. Probable secD, FT protein-export membrane protein (integral membrane protein) FT (see citation below), equivalent to FT P38387|SECD_MYCLE|ML0487|MLCB1259.05|B1177_C1_164 FT PROTEIN-EXPORT MEMBRANE PROTEIN from Mycobacterium leprae FT (571 aa), FASTA scores: opt: 2948, E(): 2.6e-97, (80.6% FT identity in 583 aa overlap). Also similar to others e.g. FT Q9AE07|SECD from Corynebacterium glutamicum (Brevibacterium FT flavum) (637 aa), FASTA scores: opt: 1023, E(): 1.9e-29, FT (44.95% identity in 596 aa overlap); Q53955|SECD_STRCO from FT Streptomyces coelicolor (570 aa), FASTA scores: opt: 864, FT E(): 7.2e-24, (38.0% identity in 584 aa overlap); FT O33517|SECD_RHOCA from Rhodobacter capsulatus FT (Rhodopseudomonas capsulata) (554 aa), FASTA scores: opt: FT 551, E(): 7.6e-13, (32.25% identity in 304 aa overlap); FT etc. Equivalent to AAK46977 from Mycobacterium tuberculosis FT strain CDC1551 (554 aa) but longer 19 aa. BELONGS TO THE FT SECD/SECF FAMILY, SECD FAMILY. PART OF THE PROKARYOTIC FT PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE FT SECA|Rv3240c, SECD, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 FT AND SECY|Rv0732." FT /db_xref="GOA:Q50634" FT /db_xref="InterPro:IPR003335" FT /db_xref="UniProtKB/Swiss-Prot:Q50634" FT /protein_id="CAB01256.1" FT /translation="MASSSAPVHPARYLSVFLVMLIGIYLLVFFTGDKHTAPKLGIDLQ FT GGTRVTLTARTPDGSAPSREALAQAQQIISARVNGLGVSGSEVVVDGDNLVITVPGNDG FT SEARNLGQTARLYIRPVLNSMPAQPAAEEPQPAPSAEPQPPGQPAAPPPAQSGAPASPQ FT PGAQPRPYPQDPAPSPNPTSPASPPPAPPAEAPATDPRKDLAERIAQEKKLRQSTNQYM FT QMVALQFQATRCESDDILAGNDDPKLPLVTCSTDHKTAYLLAPSIISGDQIQNATSGMD FT QRGIGYVVDLQFKGPAANIWADYTAAHIGTQTAFTLDSQVVSAPQIQEAIPGGRTQISG FT GDPPFTAATARQLANVLKYGSLPLSFEPSEAQTVSATLGLSSLRAGMIAGAIGLLLVLV FT YSLLYYRVLGLLTALSLVASGSMVFAILVLLGRYINYTLDLAGIAGLIIGIGTTADSFV FT VFFERIKDEIREGRSFRSAVPRGWARARKTIVSGNAVTFLAAAVLYFLAIGQVKGFAFT FT LGLTTILDLVVVFLVTWPLVYLASKSSLLAKPAYNGLGAVQQVARERRAMARTGRG" FT CDS complement(142810..143157) FT /transl_table=11 FT /gene="yajC" FT /locus_tag="Rv2588c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN SECRETION FT FACTOR YAJC" FT /function="THOUGHT TO BE INVOLVED IN SECRETION APPARATUS." FT /note="Rv2588c, (MTCY227.13), len: 115 aa. Probable yajC, FT secretion factor, a conserved membrane protein (see FT Braunstein & Belisle 2000), equivalent to FT Q49647|YP88_MYCLE|ML0486|MLCB1259.04|B1177_C3_235 FT HYPOTHETICAL 12.8 KDA PROTEIN from Mycobacterium leprae FT (114 aa), FASTA scores: opt: 499, E(): 2.7e-26, (77.0% FT identity in 100 aa overlap). Also similar to other proteins FT e.g. Q9AE08 HYPOTHETICAL 13.5 KDA PROTEIN from FT Corynebacterium glutamicum (Brevibacterium flavum) (121 FT aa), FASTA scores: opt: 222, E(): 5e-08, (39.8% identity in FT 103 aa overlap); Q9L292|SCL2.07c PUTATIVE SECRETED PROTEIN FT from Streptomyces coelicolor (169 aa), FASTA scores: opt: FT 203, E(): 1.2e-06, (32.05% identity in 106 aa overlap); FT Q9CDT0|YWAB UNKNOWN PROTEIN from Lactococcus lactis (subsp. FT lactis) (Streptococcus lactis) (110 aa), FASTA scores: opt: FT 150, E(): 0.0026, (30.85% identity in 94 aa overlap); etc." FT /db_xref="GOA:P65025" FT /db_xref="InterPro:IPR003849" FT /db_xref="UniProtKB/Swiss-Prot:P65025" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01255.1" FT /translation="MESFVLFLPFLLIMGGFMYFASRRQRRAMQATIDLHDSLQPGERV FT HTTSGLEATIVAIADDTIDLEIAPGVVTTWMKLAIRDRILPDDDIDEELNEDLDKDVDD FT VAGERRVTNDS" FT CDS 143324..144673 FT /transl_table=11 FT /gene="gabT" FT /locus_tag="Rv2589" FT /product="4-AMINOBUTYRATE AMINOTRANSFERASE GABT FT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) FT (GLUTAMATE:SUCCINIC SEMIALDEHYDE TRANSAMINASE) (GABA FT AMINOTRANSFERASE) (GABA-AT)" FT /function="INVOLVED IN 4-AMINOBUTYRATE (GABA) DEGRADATION FT PATHWAY [CATALYTIC ACTIVITY: 4-AMINOBUTANOATE + FT 2-OXOGLUTARATE = SUCCINATE SEMIALDEHYDE + L-GLUTAMATE]." FT /EC_number="2.6.1.9" FT /note="Rv2589, (MTCY227.12c), len: 449 aa. Probable gabT, FT 4-aminobutyrate aminotransferase (EC 2.6.1.9), equivalent FT to P40829|GABT_MYCLE|ML0485|MLCB1259.03c|B1177_F2_67 FT 4-AMINOBUTYRATE AMINOTRANSFERASE (446 aa), FASTA scores: FT opt: 2468, E(): 4.5e-141, (83.75% identity in 449 aa FT overlap). Also highly similar to others e.g. O86823|GABT FT from Streptomyces coelicolor (444 aa), FASTA scores: opt: FT 1832, E(): 8e-103, (63.9% identity in 443 aa overlap); FT AAK79395|CAC1427 from Clostridium acetobutylicum (445 aa), FT FASTA scores: opt: 1283, E(): 8.4e-70, (45.75% identity in FT 433 aa overlap); Q9KE66|BH0991 from Bacillus halodurans FT (443 aa), FASTA scores: opt: 1224, E(): 2.9e-66, (44.55% FT identity in 431 aa overlap); etc. Contains PS00600 FT Aminotransferases class-III pyridoxal-phosphate attachment FT site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE." FT /db_xref="GOA:P63504" FT /db_xref="HSSP:1QJ3" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P63504" FT /protein_id="CAB01254.1" FT /translation="MASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARA FT GGGIVEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRTQVAEFTHTCFMVTPYEGYVAV FT AEQLNRITPGSGPKRSVLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLTMAL FT TAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANN FT LAALVIEPIQGEGGFIVPAEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEG FT PDGLEPDLICTAKGIADGLPLSAVTGRAEIMNAPHVGGLGGTFGGNPVACAAALATIAT FT IESDGLIERARQIERLVTDRLTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTE FT RLATAAHAAGVIILTCGMFGNIIRLLPPLTIGDELLSEGLDIVCAILADL" FT misc_feature 144098..144220 FT /note="PS00600 Aminotransferases class-III FT pyridoxal-phosphate attachment site" FT CDS 144835..148341 FT /transl_table=11 FT /gene="fadD9" FT /locus_tag="Rv2590" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD9 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv2590, (MTCY227.11c), len: 1168 aa. Probable fadD9, FT fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to FT O69484|FADD9 (alias Q9CCT4|FADD9|ML0484 but longer 14 aa) FT PUTATIVE ACYL-CoA SYNTHETASE from Mycobacterium leprae FT (1174 aa), FASTA scores: opt: 5247, E(): 0, (68.0% identity FT in 1178 aa overlap); Q49651|LCLA|B1177_F1_23 PUTATIVE FT LONG-CHAIN-FATTY-ACID--CoA LIGASE from Mycobacterium leprae FT (827 aa), FASTA scores: opt: 3170, E(): 7.1e-181, (63.9% FT identity in 770 aa overlap). N-terminal (700 residues) FT similar to other long chain fatty acid ligases. And FT C-terminus highly similar to C-terminus of Q9XCF2|PSTB PSTB FT PROTEIN from Mycobacterium avium (2552 aa), FASTA scores: FT opt: 2083, E(): 8.4e-116, (40.8% identity in 1150 aa FT overlap) (and weak similarity on N-terminus); FT Q49653|POL1|B1177_F2_70 POL1 PROTEIN from Mycobacterium FT leprae (400 aa), FASTA scores: opt: 2066, E(): 2e-115, FT (76.25% identity in 404 aa overlap). C-terminal part highly FT similar to polyketide synthases and peptides synthases FT (weak similarity on N-terminus) e.g. FT Q10896|Rv0101|MTCY251.20|NRP PROBABLE PEPTIDE SYNTHETASE FT from Mycobacterium tuberculosis (2512 aa), FASTA scores: FT opt: 1988, E(): 3.7e-110, (40.2% identity in 1181 aa FT overlap); etc. Contains PS00455 putative AMP-binding domain FT signature, and PS00061 Short-chain alcohol dehydrogenase FT family signature. SEEMS TO BELONG TO THE ATP-DEPENDENT FT AMP-BINDING ENZYME FAMILY, AND TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q50631" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q50631" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01284.1" FT /translation="MSINDQRLTRRVEDLYASDAQFAAASPNEAITQAIDQPGVALPQL FT IRMVMEGYADRPALGQRALRFVTDPDSGRTMVELLPRFETITYRELWARAGTLATALSA FT EPAIRPGDRVCVLGFNSVDYTTIDIALIRLGAVSVPLQTSAPVTGLRPIVTETEPTMIA FT TSIDNLGDAVEVLAGHAPARLVVFDYHGKVDTHREAVEAARARLAGSVTIDTLAELIER FT GRALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRKSSGWFEPSGYPSI FT TLNFMPMSHVGGRQVLYGTLSNGGTAYFVAKSDLSTLFEDLALVRPTELCFVPRIWDMV FT FAEFHSEVDRRLVDGADRAALEAQVKAELRENVLGGRFVMALTGSAPISAEMTAWVESL FT LADVHLVEGYGSTEAGMVLNDGMVRRPAVIDYKLVDVPELGYFGTDQPYPRGELLVKTQ FT TMFPGYYQRPDVTAEVFDPDGFYRTGDIMAKVGPDQFVYLDRRNNVLKLSQGEFIAVSK FT LEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRHGIENLKPVISESLQEVARAA FT GLQSYEIPRDFIIETTPFTLENGLLTGIRKLARPQLKKFYGERLERLYTELADSQSNEL FT RELRQSGPDAPVLPTLCRAAAALLGSTAADVRPDAHFADLGGDSLSALSLANLLHEIFG FT VDVPVGVIVSPASDLRALADHIEAARTGVRRPSFASIHGRSATEVHASDLTLDKFIDAA FT TLAAAPNLPAPSAQVRTVLLTGATGFLGRYLALEWLDRMDLVNGKLICLVRARSDEEAQ FT ARLDATFDSGDPYLVRHYRELGAGRLEVLAGDKGEADLGLDRVTWQRLADTVDLIVDPA FT ALVNHVLPYSQLFGPNAAGTAELLRLALTGKRKPYIYTSTIAVGEQIPPEAFTEDADIR FT AISPTRRIDDSYANGYANSKWAGEVLLREAHEQCGLPVTVFRCDMILADTSYTGQLNLP FT DMFTRLMLSLAATGIAPGSFYELDAHGNRQRAHYDGLPVEFVAEAICTLGTHSPDRFVT FT YHVMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEWLQRFETSLRALPDRQRHAS FT LLPLLHNYREPAKPICGSIAPTDQFRAAVQEAKIGPDKDIPHLTAAIIAKYISNLRLLG FT LL" FT misc_feature 145558..145593 FT /note="PS00455 Putative AMP-binding domain signature" FT misc_feature 147631..147717 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 148515..150146 FT /transl_table=11 FT /gene="PE_PGRS44" FT /locus_tag="Rv2591" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2591, (MTCY227.10c), len: 543 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT others e.g. O53845|Rv0834c|MTV043.26c from Mycobacterium FT tuberculosis (882 aa), FASTA scores: opt: 1813, E(): FT 5.8e-66, (55.3% identity in 568 aa overlap). Equivalent to FT AAK46982 from Mycobacterium tuberculosis strain CDC1551 FT (505 aa) but longer 38 aa. Contains PS00583 pfkB family of FT carbohydrate kinases signature 1." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:Q50630" FT /protein_id="CAE55501.1" FT /translation="MSFVTAAPEMLATAAQNVANIGTSLSAANATAAASTTSVLAAGAD FT EVSQAIARLFSDYATHYQSLNAQAAAFHHSFVQTLNAAGGAYSSAEAANASAQALEQNL FT LAVINAPAQALFGRPLIGNGANGTAASPNGGDGGILYGNGGNGFSQTTAGVAGGAGGSA FT GLIGNGGNGGAGGAGAAGGAGGAGGWLLGNGGAGGPGGPTDVPAGTGGAGGAGGDAPLI FT GWGGNGGPGGFAAFGNGGAGGNGGASGSLFGVGGAGGVGGSSEDVGGTGGAGGAGRGLF FT LGLGGDGGAGGTSNNNGGDGGAGGTAGGRLFSLGGDGGNGGAGTAIGSNAGDGGAGGDS FT SALIGYAQGGSGGLGGFGESTGGDGGLGGAGAVLIGTGVGGFGGLGGGSNGTGGAGGAG FT GTGATLIGLGAGGGGGIGGFAVNVGNGVGGLGGQGGQGAALIGLGAGGAGGAGGATVVG FT LGGNGGDGGDGGGLFSIGVGGDGGNAGNGAMPANGGNGGNAGVIANGSFAPSFVGFGGN FT GGNGVNGGTGGSGGILFGANGANGPS" FT misc_feature 149670..149741 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1" FT CDS complement(150163..151197) FT /transl_table=11 FT /gene="ruvB" FT /locus_tag="Rv2592c" FT /product="PROBABLE HOLLIDAY JUNCTION DNA HELICASE RUVB" FT /function="FORMS A COMPLEX WITH RUVA. RUVB COULD POSSESS FT WEAK ATPASE ACTIVITY, WHICH WILL BE STIMULATED BY THE RUVA FT PROTEIN IN THE PRESENCE OF DNA. THE RUVA-RUVB COMPLEX IN FT THE PRESENCE OF ATP RENATURES CRUCIFORM STRUCTURE IN FT SUPERCOILED DNA WITH PALINDROMIC SEQUENCE, INDICATING THAT FT IT MAY PROMOTE STRAND EXCHANGE REACTIONS IN HOMOLOGOUS FT RECOMBINATION. RUVAB IS AN HELICASE THAT MEDIATES THE FT HOLLIDAY JUNCTION MIGRATION BY LOCALIZED DENATURATION AND FT REANNELING." FT /EC_number="3.6.1.-" FT /note="Rv2592c, (MTCY227.09), len: 344 aa. Probable ruvB, FT Holliday junction binding protein (EC 3.6.1.-) (see Mizrahi FT & Andersen 1998), equivalent to FT P40833|RUVB_MYCLE|ML0483|B1177_C3_227 HOLLIDAY JUNCTION DNA FT HELICASE from Mycobacterium leprae (349 aa), FASTA scores: FT opt: 2059, E(): 2.1e-106, (94.45% identity in 342 aa FT overlap). Also highly similar to others e.g. Q9AE09|RUVB FT from Corynebacterium glutamicum (Brevibacterium flavum) FT (363 aa), FASTA scores: opt: 1651, E(): 6.5e-84, (75.6% FT identity in 332 aa overlap); Q9L291|RUVB from Streptomyces FT coelicolor (357 aa), FASTA scores: opt: 1530, E(): 3e-77, FT (68.2% identity in 343 aa overlap); FT P08577|RUVB_ECOLI|B1860|Z2912|ECS2570 from Escherichia coli FT strains K12 and O157:H7 (336 aa), FASTA scores: opt: 1284, FT E(): 1e-63, (55.45% identity in 330 aa overlap); etc. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT BELONGS TO THE RUVB FAMILY." FT /db_xref="GOA:P66753" FT /db_xref="HSSP:1IN5" FT /db_xref="InterPro:IPR003959" FT /db_xref="UniProtKB/Swiss-Prot:P66753" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01285.1" FT /translation="MTERSDRDVSPALTVGEGDIDVSLRPRSLREFIGQPRVREQLQLV FT IEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSSLRVTSGPALERAGDLAAMLSN FT LVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATT FT RSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGADAGAEIARRSRGTPR FT IANRLLRRVRDFAEVRADGVITRDVAKAALEVYDVDELGLDRLDRAVLSALTRSFGGGP FT VGVSTLAVAVGEEAATVEEVCEPFLVRAGMVARTPRGRVATALAWTHLGMTPPVGASQP FT GLFE" FT misc_feature complement(150988..151011) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(151194..151784) FT /transl_table=11 FT /gene="ruvA" FT /locus_tag="Rv2593c" FT /product="PROBABLE HOLLIDAY JUNCTION DNA HELICASE RUVA" FT /function="FORMS A COMPLEX WITH RUVB. RUVA STIMULATES, IN FT THE PRESENCE OF DNA, THE WEAK ATPASE ACTIVITY OF RUVB. THE FT RUVA-RUVB COMPLEX IN THE PRESENCE OF ATP RENATURES FT CRUCIFORM STRUCTURE IN SUPERCOILED DNA WITH PALINDROMIC FT SEQUENCE, INDICATING THAT IT MAY PROMOTE STRAND EXCHANGE FT REACTIONS IN HOMOLOGOUS RECOMBINATION. RUVAB IS AN HELICASE FT THAT MEDIATES THE HOLLIDAY JUNCTION MIGRATION BY LOCALIZED FT DENATURATION AND REANNELING." FT /note="Rv2593c, (MTCY227.08), len: 196 aa. Probable ruvA, FT Holliday junction binding protein (see citations below), FT equivalent to P40832|RUVA_MYCLE|ML0482|B1177_C2_188 FT HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium leprae FT (203 aa), FASTA scores: opt: 923, E(): 9.9e-50, (76.85% FT identity in 203 aa overlap). Also highly similar to others FT e.g. Q9L290|RUVA from Streptomyces coelicolor (201 aa) (201 FT aa), FASTA scores: opt: 549, E(): 8.2e-27, (47.55% identity FT in 204 aa overlap); Q9AE10|RUVA from Corynebacterium FT glutamicum (Brevibacterium flavum) (206 aa), FASTA scores: FT opt: 440, E(): 4e-20, (47.1% identity in 206 aa overlap); FT P08576|RUVA_ECOLI|B1861|Z2913|ECS2571 from Escherichia coli FT strains K12 and O157:H7 (203 aa), FASTA scores: opt: 312, FT E(): 2.8e-12, (34.85% identity in 201 aa overlap); etc. FT BELONGS TO THE RUVA FAMILY.." FT /db_xref="GOA:P66744" FT /db_xref="InterPro:IPR000085" FT /db_xref="PDB:2H5X" FT /db_xref="UniProtKB/Swiss-Prot:P66744" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01282.1" FT /translation="MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEAR FT LITAMIVREDSMTLYGFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLADG FT NVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGFAAK FT QAEEATDTVLAANHDATTSSALRSALSLLGKAR" FT CDS complement(151781..152347) FT /transl_table=11 FT /gene="ruvC" FT /locus_tag="Rv2594c" FT /product="PROBABLE CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE FT RUVC (HOLLIDAY JUNCTION NUCLEASE) (HOLLIDAY JUNCTION FT RESOLVASE)" FT /function="NUCLEASE THAT RESOLVES HOLLIDAY JUNCTION FT INTERMEDIATES IN GENETIC RECOMBINATION. CLEAVES THE FT CRUCIFORM STRUCTURE IN SUPERCOILED DNA BY NICKING TO FT STRANDS WITH THE SAME POLARITY AT SITES SYMMETRICALLY FT OPPOSED AT THE JUNCTION IN THE HOMOLOGOUS ARMS AND LEAVES A FT 5'TERMINAL PHOSPHATE AND A 3'TERMINAL HYDROXYL GROUP FT [CATALYTIC ACTIVITY: ENDONUCLEOLYTIC CLEAVAGE AT A JUNCTION FT SUCH AS A RECIPROCAL SINGLE-STRANDED CROSSOVER BETWEEN TWO FT HOMOLOGOUS DNA DUPLEXES (HOLLIDAY JUNCTION)]." FT /note="EC 3.1.22.4" FT /note="Rv2594c, (MTCY227.07), len: 188 aa. Probable ruvC, FT Holliday junction resolvase (EC 3.1.22.4) (see citations FT below), equivalent to P40834|RUVC_MYCLE|ML0481|B1177_C3_226 FT CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE from Mycobacterium FT leprae (188 aa), FASTA scores: opt: 984, E(): 2.3e-55, FT (81.0% identity in 184 aa overlap). Also highly similar to FT others e.g. Q9AE11|RUVC from Corynebacterium glutamicum FT (Brevibacterium flavum) (221 aa), FASTA scores: opt: 713, FT E(): 3.6e-38, (56.9% identity in 188 aa overlap); FT Q9L289|RUVC_STRCO|SCL2.10c from Streptomyces coelicolor FT (188 aa), FASTA scores: opt: 704, E(): 1.2e-37, (60.65% FT identity in 178 aa overlap); P24239|RUVC_ECOLI|B1863 from FT Escherichia coli strain K12 (172 aa), FASTA scores: opt: FT 322, E(): 1.6e-13, (38.65% identity in 163 aa overlap); FT etc. BELONGS TO THE RUVC FAMILY. COFACTOR: MAGNESIUM." FT /db_xref="GOA:P66760" FT /db_xref="HSSP:1HJR" FT /db_xref="InterPro:IPR002176" FT /db_xref="UniProtKB/Swiss-Prot:P66760" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01281.1" FT /translation="MRVMGVDPGLTRCGLSLIESGRGRQLTALDVDVVRTPSDAALAQR FT LLAISDAVEHWLDTHHPEVVAIERVFSQLNVTTVMGTAQAGGVIALAAAKRGVDVHFHT FT PSEVKAAVTGNGSADKAQVTAMVTKILALQAKPTPADAADALALAICHCWRAPTIARMA FT EATSRAEARAAQQRHAYLAKLKAAR" FT CDS 152456..152701 FT /transl_table=11 FT /locus_tag="Rv2595" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2595, (MTCY227.06c), len: 81 aa. Conserved FT hypothetical protein, showing similarity with various FT bacterial proteins e.g. O28268|AF2011 CONSERVED FT HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (86 aa), FT FASTA scores: opt: 120, E(): 0.13, (34.35% identity in 67 FT aa overlap); CAC46196|SMC01176 CONSERVED HYPOTHETICAL FT PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) FT (79 aa), FASTA scores: opt: 119, E(): 0.14, (33.35% FT identity in 63 aa overlap); P37554|SP5T_BACSU|SPOVT STAGE V FT SPORULATION PROTEIN T from Bacillus subtilis (178 aa), FT FASTA scores: opt: 104, E(): 2.9, (51.45% identity in 35 aa FT overlap); etc. Also similar to O07779|Rv0599c|MTCY19H5.23 FT hypothetical protein from Mycobacterium tuberculosis (78 FT aa), FASTA scores: opt: 160, E(): 0.00026, (35.8% identity FT in 81 aa overlap)." FT /db_xref="InterPro:IPR007159" FT /db_xref="UniProtKB/Swiss-Prot:P65027" FT /protein_id="CAB01280.1" FT /translation="MRTTIDVAGRLVIPKRIRERLGLRGNDQVEITERDGRIEIEPAPT FT GVELVREGSVLVARPERPLPPLTDEIVRETLDRTRR" FT CDS 152698..153102 FT /transl_table=11 FT /locus_tag="Rv2596" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2596, (MTCY227.05c), len: 134 aa. Conserved FT hypothetical protein, similar to O07780|Rv0598c|MTCY19H5.24 FT HYPOTHETICAL 14.8 KDA PROTEIN from Mycobacterium FT tuberculosis (137 aa), FASTA scores: opt: 254, E(): FT 8.8e-11, (41.55% identity in 130 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/Swiss-Prot:Q50625" FT /protein_id="CAB01279.1" FT /translation="MIAPDTSVLVAGFATWHEGHEAAVRALNRGVHLIAHAAVETYSVL FT TRLPPPHRIAPVAVHAYLADITSSNYLALDACSYRGLTDHLAEHDVTGGATYDALVGFT FT AKAAGAKLLTRDLRAVETYERLRVEVELVT" FT CDS 153319..153939 FT /transl_table=11 FT /locus_tag="Rv2597" FT /product="PROBABLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2597, (MTCY227.04c), len: 206 aa. Probable FT membrane protein." FT /db_xref="GOA:P65029" FT /db_xref="UniProtKB/Swiss-Prot:P65029" FT /protein_id="CAB01278.1" FT /translation="MGNLLVVIAVALFIAAIVVLVVAIRRPKTPATPGGRRDPLAFDAM FT PQFGPRQLGPGAIVSHGGIDYVVRGSVTFREGPFVWWEHLLEGGDTPTWLSVQEDDGRL FT ELAMWVKRTDLGLQPGGQHVIDGVTFQETERGHAGYTTEGTTGLPAGGEMDYVDCASAG FT QGADESMLLSFERWAPDMGWEIATGKSVLAGELTVYPAPPVSA" FT CDS 153950..154444 FT /transl_table=11 FT /locus_tag="Rv2598" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2598, (MTCY227.03c), len: 164 aa. Conserved FT hypothetical protein, showing similarity with hypothetical FT proteins from Streptomyces coelicolor e.g. Q9X8S3|SCH10.34c FT (185 aa), FASTA scores: opt: 197, E(): 3.5e-06, (34.75% FT identity in 167 aa overlap); and Q9L088|SCC24.29c (172 aa), FT FASTA scores: opt: 149, E(): 0.0053, (37.65% identity in FT 146 aa overlap). Equivalent to AAK46988 from Mycobacterium FT tuberculosis strain CDC1551 (154 aa) but longer 10 aa." FT /db_xref="UniProtKB/Swiss-Prot:P65031" FT /protein_id="CAB01277.1" FT /translation="MPLHQLAIAPVDVSGALLGLVLNAPAPRPLATHRLAHTDGSALQL FT GVLGASHVVTVEGRFCEEVSCVARSRGGDLPESTHAPGYHLQSHTETHDEAAFRRLARH FT LRERCTRATGWLGGVFPGDDAALTALAAEPDGTGWRWRTWHLYPSASGGTVVHTTSRWR FT P" FT CDS 154441..154872 FT /transl_table=11 FT /locus_tag="Rv2599" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2599, (MTCY227.02c), len: 143 aa. Probable FT conserved membrane protein, equivalent to Q9K536|2599 FT HYPOTHETICAL 15.0 KDA PROTEIN (FRAGMENT) from Mycobacterium FT paratuberculosis (143 aa), FASTA scores: opt: 691, E(): FT 1.7e-33, (68.55% identity in 143 aa overlap). Shows weak FT similarity with Q9L089|SCC24.28c PUTATIVE LIPOPROTEIN from FT Streptomyces coelicolor (131 aa), FASTA scores: opt: 130, FT E(): 0.52, (26.45% identity in 136 aa overlap). Contains FT PS00626 Regulator of chromosome condensation (RCC1) FT signature 2." FT /db_xref="GOA:Q50622" FT /db_xref="UniProtKB/Swiss-Prot:Q50622" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01276.1" FT /translation="MSRNRLFLVAGSLAVAAAVSLISGITLLNRDVGSYIASHYRQESR FT DVNGTRYLCTGSPKQVATTLVKYQTPAARASHTDTEYLRYRNNIVTVGPDGTYPCIIRV FT ENLSAGYNHGAYVFLGPGFTPGSPSGGSGGSPGGPGGSK" FT misc_feature 154759..154791 FT /note="PS00626 Regulator of chromosome condensation (RCC1) FT signature 2" FT CDS 154954..155355 FT /transl_table=11 FT /locus_tag="Rv2600" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2600, (MTCY277.01c, MTV001.01), len: 133 aa. FT Probable conserved integral membrane protein, equivalent FT (but shorter 18 aa) to Q9K537|YQ00_MYCPA HYPOTHETICAL FT PROTEIN RV2600 HOMOLOG from Mycobacterium paratuberculosis FT (151 aa), FASTA scores: opt: 543, E(): 4.2e-28, (62.9% FT identity in 132 aa overlap). Also some similarity with FT other hypothetical or membrane proteins e.g. FT Q9L090|SCC24.27c PUTATIVE INTEGRAL MEMBRANE PROTEIN from FT Streptomyces coelicolor (146 aa), FASTA scores: opt: 241, FT E(): 8.7e-09, (34.8% identity in 135 aa overlap); FT O58487|PH0773 HYPOTHETICAL 15.0 KDA PROTEIN from Pyrococcus FT horikoshii (138 aa), FASTA scores: opt: 116, E(): 0.84, FT (34.35% identity in 96 aa overlap); etc. Equivalent to FT AAK46990 from Mycobacterium tuberculosis strain CDC1551 FT (152 aa) but shorter 19 aa." FT /db_xref="GOA:P68915" FT /db_xref="InterPro:IPR007140" FT /db_xref="UniProtKB/Swiss-Prot:P68915" FT /protein_id="CAB01286.1" FT /translation="MVATVLYFLVGAAVLVAGFLMVNLLTPGDLRRLVFIDRRPNAVVL FT AATMYVALAIVTIAAIYASSNQLAQGLIGVAVYGIVGVALQGVALVILEIAVPGRFREH FT IDAPALHPAVFATAVMLLAVAGVIAAALS" FT CDS 155352..156923 FT /transl_table=11 FT /gene="speE" FT /locus_tag="Rv2601" FT /product="PROBABLE SPERMIDINE SYNTHASE SPEE (PUTRESCINE FT AMINOPROPYLTRANSFERASE) (AMINOPROPYLTRANSFERASE) (SPDSY)" FT /function="INVOLVED IN THE BIOSYNTHESIS OF SPERMIDINE FROM FT ARGININE (AT THE FIFTH, LAST STEP). THE ACTIVITY IS THOUGHT FT TO BE REGULATED MAINLY BY THE AVAILABILITY OF FT DECARBOXYLATED S-ADENOSYLMETHIONINE [CATALYTIC ACTIVITY: FT S-ADENOSYLMETHIONINAMINE + PUTRESCINE = FT 5'-METHYLTHIOADENOSINE + SPERMIDINE]." FT /EC_number="2.5.1.16" FT /note="Rv2601, (MTCI270.04c-MTV001.02), len 523 aa. FT Probable speE, spermidine synthase (EC 2.5.1.16), highly FT similar to many e.g. Q9L091|SCC24.26c from Streptomyces FT coelicolor (531 aa), FASTA scores: opt: 1493, E(): 1.3e-79, FT (48.45% identity in 514 aa overlap); Q9X8S2|SCH10.33c from FT Streptomyces coelicolor (554 aa), FASTA scores: opt: 1045, FT E(): 1.7e-53, (40.55% identity in 525 aa overlap); FT P09158|SPEE_ECOLI|B0121 from Escherichia coli strain K12 FT (287 aa), FASTA scores: opt: 368, E(): 2.9e-14, (30.5% FT identity in 272 aa overlap); etc." FT /db_xref="GOA:O33279" FT /db_xref="HSSP:1MJF" FT /db_xref="InterPro:IPR001045" FT /db_xref="UniProtKB/Swiss-Prot:O33279" FT /protein_id="CAE55502.1" FT /translation="MTSTRQAGEATEASVRWRAVLLAAVAACAACGLVYELALLTLAAS FT LNGGGIVATSLIVAGYIAALGAGALLIKPLLAHAAIAFIAVEAVLGIIGGLSAAALYAA FT FAFLDELDGSTLVLAVGTALIGGLVGAEVPLLMTLLQRGRVAGAADAGRTLANLNAADY FT LGALVGGLAWPFLLLPQLGMIRGAAVTGIVNLAAAGVVSIFLLRHVVSGRQLVTALCAL FT AAALGLIATLLVHSHDIETTGRQQLYADPIIAYRHSAYQEIVVTRRGDDLRLYLDGGLQ FT FCTRDEYRYTESLVYPAVSDGARSVLVLGGGDGLAARELLRQPGIEQIVQVELDPAVIE FT LARTTLRDVNAGSLDNPRVHVVIDDAMSWLRGAAVPPAGFDAVIVDLRDPDTPVLGRLY FT STEFYALAARALAPGGLMVVQAGSPYSTPTAFWRIISTIRSAGYAVTPYHVHVPTFGDW FT GFALARLTDIAPTPAVPSTAPALRFLDQQVLEAATVFSGDIRPRTLDPSTLDNPHIVED FT MRHGWD" FT CDS 157034..157321 FT /transl_table=11 FT /locus_tag="Rv2601A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2601A, 95 aa. Hypothetical protein, showing few FT similarity to O53811|Rv0748 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (88 aa), FASTA scores: opt: FT 132, E(): 0.017, (29.25% identity in 82 aa overlap); FT O53218|Rv2493 (73 aa), FASTA scores: opt: 107, E(): 0.97, FT (33.75% identity in 83 aa overlap); and FT Q10799|YS71_MYCTU|Rv2871 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: FT 108, E(): 0.91, (41.00% identity in 39 aa overlap)." FT /db_xref="GOA:Q8VJF3" FT /db_xref="UniProtKB/TrEMBL:Q8VJF3" FT /protein_id="CAE55503.1" FT /translation="MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGA FT PIPTPRRVQLPLVHCGGAATREQEMTPERVAAALLDQEAQWWSGHDDAAL" FT CDS 157308..157748 FT /transl_table=11 FT /locus_tag="Rv2602" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2602, (MTCI270A.03c), len: 146 aa. Conserved FT hypothetical protein, some weak similarity with proteins FT from Mycobacterium tuberculosis (strains H37Rv and CDC1551) FT e.g. O50457|Rv1242|MTV006.14 (143 aa), FASTA scores: opt: FT 147, E(): 0.0021, (26.25% identity in 141 aa overlap); FT P95023|Rv2530c|MTCY159.26 (139 aa), FASTA scores: opt: 131, FT E(): 0.027, (33.35% identity in 135 aa overlap); FT O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 125, FT E(): 0.072, (26.45% identity in 140 aa overlap)." FT /db_xref="InterPro:IPR006226" FT /db_xref="UniProtKB/TrEMBL:O33215" FT /protein_id="CAB10839.1" FT /translation="MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQS FT LLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDDRIVLAGAEPDGLEAQWRAFAVRQS FT PAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK" FT CDS complement(157769..158524) FT /transl_table=11 FT /locus_tag="Rv2603c" FT /product="HIGHLY CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2603c, (MTCI270A.02), len: 251 aa. Highly FT conserved hypothetical protein, equivalent to FT Q49645|YQ03_MYCLE|ML0475|U1177B|B1177_C2_181 HYPOTHETICAL FT 26.6 KDA PROTEIN from Mycobacterium leprae (251 aa), FASTA FT scores: opt: 1514, E(): 2.2e-84, (92.45% identity in 251 aa FT overlap). Also highly similar to Q9L288|SCL2.11c FT HYPOTHETICAL 26.8 KDA PROTEIN from Streptomyces coelicolor FT (250 aa), FASTA scores: opt: 1268, E(): 1.5e-69, (76.7% FT identity in 249 aa overlap); Q9AE12|YFCA HYPOTHETICAL FT STRUCTURAL PROTEIN from Corynebacterium glutamicum FT (Brevibacterium flavum) (251 aa), FASTA scores: opt: 1231, FT E(): 2.6e-67, (72.9% identity in 251 aa overlap); FT O83487|Y474_TREPA|TP0474 HYPOTHETICAL PROTEIN from FT Treponema pallidum (245 aa), FASTA scores: opt: 780, E(): FT 4.4e-40, (47.75% identity in 245 aa overlap); FT P24237|YEBC_ECOLI|B1864 PROTEIN YEBC from Escherichia coli FT strain K12 (246 aa), FASTA scores: opt: 776, E(): 7.6e-40, FT (47.8% identity in 249 aa overlap); etc." FT /db_xref="HSSP:1KON" FT /db_xref="InterPro:IPR017856" FT /db_xref="UniProtKB/Swiss-Prot:P67177" FT /protein_id="CAB10838.1" FT /translation="MSGHSKWATTKHKKAVVDARRGKMFARLIKNIEVAARVGGGDPAG FT NPTLYDAIQKAKKSSVPNENIERARKRGAGEEAGGADWQTIMYEGYAPNGVAVLIECLT FT DNRNRAASEVRVAMTRNGGTMADPGSVSYLFSRKGVVTLEKNGLTEDDVLAAVLEAGAE FT DVNDLGDSFEVISEPAELVAVRSALQDAGIDYESAEASFQPSVSVPVDLDGARKVFKLV FT DALEDSDDVQNVWTNVDVSDEVLAALDDE" FT CDS complement(158657..159253) FT /transl_table=11 FT /locus_tag="Rv2604c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2604c, (MTCY01A10.29, MTCI270A.01), len: 198 aa. FT Conserved hypothetical protein, equivalent (but shorter 21 FT aa) to Q49637|HISH|B1177_C1_149 HISH PROTEIN (BELONGS TO FT THE YFL060C/YAAE/HI1648 FAMILY) (alias Q9CCT5|ML0474 FT HYPOTHETICAL PROTEIN 223 aa) from Mycobacterium leprae (219 FT aa), FASTA scores: opt: 1069, E(): 1.7e-60, (83.35% FT identity in 198 aa overlap). Also highly similar to FT hypothetical proteins or amidotransferases e.g. FT Q9L287|SCL2.12c HYPOTHETICAL 21.5 KDA PROTEIN from FT Streptomyces coelicolor (202 aa), FASTA scores: opt: 702, FT E(): 2.3e-37, (56.75% identity in 192 aa overlap); FT P37528|YAAE_BACSU HYPOTHETICAL 21.4 KDA PROTEIN from FT Bacillus subtilis (196 aa), FASTA scores: opt: 608, E(): FT 1.9e-31, (48.7% identity in 189 aa overlap); Q9KGN5|BH0023 FT AMIDOTRANSFERASE from Bacillus halodurans (196 aa), FASTA FT scores: opt: 583, E(): 7.4e-30, (48.7% identity in 195 aa FT overlap); etc. Also some similarity with several proteins FT from Mycobacterium tuberculosis e.g. FT O06589|HIS5_MYCTU|Rv1602|MT1638|MTCY336.02c FT AMIDOTRANSFERASE (EC 2.4.2.-) (206 aa), FASTA scores: opt: FT 154, E(): 0.00036, (30.6% identity in 193 aa overlap)." FT /db_xref="GOA:O06210" FT /db_xref="HSSP:1R9G" FT /db_xref="InterPro:IPR002161" FT /db_xref="UniProtKB/Swiss-Prot:O06210" FT /protein_id="CAB08636.1" FT /translation="MSVPRVGVLALQGDTREHLAALRECGAEPMTVRRRDELDAVDALV FT IPGGESTTMSHLLLDLDLLGPLRARLADGLPAYGSCAGMILLASEILDAGAAGRQALPL FT RAMNMTVRRNAFGSQVDSFEGDIEFAGLDDPVRAVFIRAPWVERVGDGVQVLARAAGHI FT VAVRQGAVLATAFHPEMTGDRRIHQLFVDIVTSAA" FT CDS complement(159261..160106) FT /transl_table=11 FT /gene="tesB2" FT /locus_tag="Rv2605c" FT /product="PROBABLE ACYL-CoA THIOESTERASE II TESB2 (TEII)" FT /function="UNKNOWN; LIPOLYTIC ENZYME INVOLVED IN CELLULAR FT METABOLISM. CAN HYDROLYZE A BROAD RANGE OF ACYL-CoA FT THIOESTERS." FT /EC_number="3.1.2.-" FT /note="Rv2605c, (MTCY01A10.28), len: 281 aa. Probable FT tesB2, acyl-CoA thioesterase II (EC 3.1.2.-), highly FT similar to others e.g. Q98EG9|MLL4250 from Rhizobium loti FT (Mesorhizobium loti) (286 aa), FASTA scores: opt: 563, E(): FT 3.9e-29, (47.75% identity in 287 aa overlap); CAC47767 from FT Rhizobium meliloti (Sinorhizobium meliloti) (294 aa), FASTA FT scores: opt: 553, E(): 1.8e-28, (49.3% identity in 280 aa FT overlap); P23911|TESB_ECOLI|B0452 from Escherichia coli FT strain K12 (285 aa), FASTA scores: opt: 487, E(): 3.1e-24, FT (41.9% identity in 277 aa overlap); etc. Also similar to FT O06135|TESB1|Rv1618|MTCY01B2.10 ACYL-CoA THIOESTERASE II FT from Mycobacterium tuberculosis (300 aa), FASTA scores: FT opt: 425, E(): 1.1e-21, (34.9% identity in 278 aa overlap). FT BELONGS TO THE C/M/P THIOESTER HYDROLASE FAMILY." FT /db_xref="GOA:O06209" FT /db_xref="HSSP:1C8U" FT /db_xref="InterPro:IPR003703" FT /db_xref="UniProtKB/TrEMBL:O06209" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08615.1" FT /translation="MSIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVSA FT VRTVDPRYMVHSLHGYFLRPGDAKERTVFLVERIRDGGSFCTRRVNAVQHGETIFSMAA FT SFQTEQEGITHQDVMPAAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRLLPG FT KASQQQVWLRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLDHAMW FT FMRPFRADEWLLYDQSSPSASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGHRSVGQ FT " FT CDS complement(160135..161034) FT /transl_table=11 FT /locus_tag="Rv2606c" FT /product="Possible pyridoxine biosynthesis protein" FT /function="Possibly involved in the biosynthesis of FT pyridoxine/pyridoxal 5-phosphate biosynthesis" FT /note="Rv2606c, (MTCY01A10.27), len: 299 aa. Possible FT pyridoxine biosynthesis protein. Highly similar to FT O07145|YQ06_MYCLE|ML0450|MLCL581.12c possible pyridoxine FT biosynthesis protein from Mycobacterium leprae (307 aa), FT FASTA scores: opt: 1686, E(): 1.5e-95, (89.7% identity in FT 291 aa overlap). Also highly similar to several pyridoxine FT biosynthesis proteins and hypothetical proteins e.g. FT Q9L286|SCL2.13c HYPOTHETICAL 32.2 KDA PROTEIN from FT Streptomyces coelicolor (303 aa), FASTA scores: opt: 1461, FT E(): 7.6e-82, (76.8% identity in 293 aa overlap); FT O14027|YEM4_SCHPO|SPAC29B12.04 HYPOTHETICAL 31.4 KDA FT PROTEIN from Schizosaccharomyces pombe (Fission yeast) (296 FT aa), FASTA scores: opt: 1318, E(): 3.8e-73, (70.35% FT identity in 290 aa overlap); Q9UW83|PYROA PROTEIN INVOLVED FT IN PYRIDOXINE BIOSYNTHESIS from Emericella nidulans FT (Aspergillus nidulans) (see citation below) (304 aa), FASTA FT scores: opt: 1288, E(): 2.6e-71, (67.9% identity in 302 aa FT overlap); etc. Contains Pfam match to entry PF01680, FT SOR_SNZ family. Contains PS01235 Uncharacterized protein FT family UPF0019 signature. Belongs to the SOR_SNZ family." FT /db_xref="GOA:P60796" FT /db_xref="InterPro:IPR001852" FT /db_xref="UniProtKB/Swiss-Prot:P60796" FT /protein_id="CAB08614.1" FT /translation="MDPAGNPATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAV FT AVMALERVPADIRAQGGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQILQTLGVD FT YIDESEVLTPADYAHHIDKWNFTVPFVCGATNLGEALRRISEGAAMIRSKGEAGTGDVS FT NATTHMRAIGGEIRRLTSMSEDELFVAAKELQAPYELVAEVARAGKLPVTLFTAGGIAT FT PADAAMMMQLGAEGVFVGSGIFKSGAPEHRAAAIVKATTFFDDPDVLAKVSRGLGEAMV FT GINVDEIAVGHRLAQRGW" FT CDS 161162..161836 FT /transl_table=11 FT /gene="pdxH" FT /locus_tag="Rv2607" FT /product="PROBABLE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE PDXH FT (PNP/PMP OXIDASE) (PYRIDOXINEPHOSPHATE OXIDASE) (PNPOX) FT (PYRIDOXINE 5'-PHOSPHATE OXIDASE)" FT /function="INVOLVED IN BIOSYNTHESIS OF PYRIDOXINE (VITAMIN FT B6) AND PYRIDOXAL PHOSPHATE. OXIDIZE PNP AND PMP INTO FT PYRIDOXAL 5'-PHOSPHATE (PLP)[CATALYTIC ACTIVITY: FT PYRIDOXAMINE 5'-PHOSPHATE + H(2)O + O(2) = PYRIDOXAL FT 5'-PHOSPHATE + NH(3) + H(2)O(2)]." FT /EC_number="1.4.3.5" FT /note="Rv2607, (MTCY01A10.26c), len: 224 aa. Probable pdxH, FT pyridoxinephosphate oxidase (EC 1.4.3.5), equivalent to FT O33065|PDXH_MYCLE|ML2131|MLCB57.46 PYRIDOXAMINE FT 5'-PHOSPHATE OXIDASE from Mycobacterium leprae (219 aa), FT FASTA scores: opt: 1038, E(): 8.3e-61, (67.1% identity in FT 219 aa overlap). Also similar to others e.g. FT Q9I4S5|PDXH|PA1049 from Pseudomonas aeruginosa (215 aa), FT FASTA scores: opt: 608, E(): 1.1e-32, (49.55% identity in FT 218 aa overlap); Q9K3V7|SCD10.19c from Streptomyces FT coelicolor (234 aa), FASTA scores: opt: 600, E(): 3.9e-32, FT (42.3% identity in 234 aa overlap); P28225|PDXH_ECOLI|B1638 FT from Escherichia coli strain K12 (217 aa), FASTA scores: FT opt: 533, E(): 8.9e-28, (40.3% identity in 216 aa overlap); FT etc. BELONGS TO THE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE FT FAMILY. COFACTOR: FMN." FT /db_xref="GOA:P65682" FT /db_xref="InterPro:IPR012349" FT /db_xref="PDB:2A2J" FT /db_xref="UniProtKB/Swiss-Prot:P65682" FT /protein_id="CAB08613.1" FT /translation="MDDDAQMVAIDKDQLARMRGEYGPEKDGCGDLDFDWLDDGWLTLL FT RRWLNDAQRAGVSEPNAMVLATVADGKPVTRSVLCKILDESGVAFFTSYTSAKGEQLAV FT TPYASATFPWYQLGRQAHVQGPVSKVSTEEIFTYWSMRPRGAQLGAWASQQSRPVGSRA FT QLDNQLAEVTRRFADQDQIPVPPGWGGYRIAPEIVEFWQGRENRMHNRIRVANGRLERL FT QP" FT CDS 162010..163752 FT /transl_table=11 FT /gene="PPE42" FT /locus_tag="Rv2608" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2608, (MTCY01A10.25c), len: 580 aa. Member of the FT Mycobacterium tuberculosis PPE family, highly similar to FT many e.g. O06828|Rv1430|MTCY493.24c from Mycobacterium FT tuberculosis (528 aa), FASTA scores: opt: 1004, E(): FT 5.9e-48, (56.05% identity in 307 aa overlap)." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/Swiss-Prot:Q79FC6" FT /protein_id="CAE55504.1" FT /translation="MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSF FT ASVTTGLAGDAWHGPASLAMTRAASPYVGWLNTAAGQAAQAAGQARLAASAFEATLAAT FT VSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASAVAT FT QLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANIGIGN FT IGDRNLGIGNTGNWNIGIGITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGTDSLLP FT LPNIPLLEYAARFITPVHPGYTATFLETPSQFFPFTGLNSLTYDVSVAQGVTNLHTAIM FT AQLAAGNEVVVFGTSQSATIATFEMRYLQSLPAHLRPGLDELSFTLTGNPNRPDGGILT FT RFGFSIPQLGFTLSGATPADAYPTVDYAFQYDGVNDFPKYPLNVFATANAIAGILFLHS FT GLIALPPDLASGVVQPVSSPDVLTTYILLPSQDLPLLVPLRAIPLLGNPLADLIQPDLR FT VLVELGYDRTAHQDVPSPFGLFPDVDWAEVAADLQQGAVQGVNDALSGLGLPPPWQPAL FT PRLF" FT CDS complement(163774..164829) FT /transl_table=11 FT /locus_tag="Rv2609c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2609c, (MTCY01A10.24), len: 351 aa. Probable FT conserved membrane protein, equivalent to FT O07146|MLCL581.13c|ML0451 HYPOTHETICAL 37.9 KDA PROTEIN FT from Mycobacterium leprae (349 aa), FASTA scores: opt: FT 1675, E(): 1.4e-95, (77.85% identity in 334 aa overlap). FT Also similar to hypothetical proteins: O69888|SC2E1.17|MUTT FT HYPOTHETICAL 19.4 KDA PROTEIN from Streptomyces coelicolor FT and Streptomyces lividans (172 aa), FASTA scores: opt: 345, FT E(): 3.5e-14, (44.7% identity in 161 aa overlap); FT Q9L285|SCL2.14c HYPOTHETICAL 19.8 KDA PROTEIN from FT Streptomyces coelicolor (180 aa), FASTA scores: opt: 179, FT E(): 0.00056, (43.25% identity in 171 aa overlap); and FT Q9RYE5|DR0004 MUTT/NUDIX FAMILY PROTEIN from Deinococcus FT radiodurans (350 aa), FASTA scores: opt: 153, E(): 0.037, FT (33.35% identity in 123 aa overlap). Contains PS00893 mutT FT domain signature. BELONGS TO THE MUTT/NUDIX FAMILY." FT /db_xref="GOA:O06205" FT /db_xref="InterPro:IPR020084" FT /db_xref="UniProtKB/TrEMBL:O06205" FT /protein_id="CAB08611.1" FT /translation="MTWLVLAGAVLLVVLVAFGAWGYQTANRLNRLNVRYDLSWQSLDS FT ALARRAVVARAVAIDAYGGAPQGSRLAALADAAEGAPRHARENAENELSAALAMVNPAS FT LPAALIAELADAEARVLLARRFHNDAVRDTLALGERRLVRLLRLGGTAVLPTYFEIVER FT PHALVHGDQGASGRRTSARVVLLDDSGAVLLLCGSDPANPAFRDGAAPKWWFTVGGQVR FT PGERLAQAAARELAEETGLRVAPADMIGPIWRRDEVFEFNGSLIDSEEFYLVHRTRRFE FT PAVQGRTELERRYIRDARWCDANDIAQLVAAGERVYPLQLGELLPAANRLVDVALDNGA FT ARDAGVPQPIR" FT misc_feature complement(164116..164175) FT /note="PS00893 mutT domain signature" FT CDS complement(164829..165965) FT /transl_table=11 FT /gene="pimA" FT /locus_tag="Rv2610c" FT /product="ALPHA-MANNOSYLTRANSFERASE PIMA" FT /function="INVOLVED IN THE FIRST MANNOSYLATION STEP IN FT PHOSPHATIDYLINOSITOL MANNOSIDE BIOSYNTHESIS (TRANSFER OF FT MANNOSE RESIDUES ONTO PI, LEADING TO THE SYNTHESIS OF FT PHOSPHATIDYLINOSITOL MONOMANNOSIDE)." FT /EC_number="2.4.1.-" FT /note="Rv2610c, (MTCY01A10.23), len: 378 aa. pimA, FT alpha-mannosyltransferase (EC 2.4.1.-) (see citations FT below), equivalent to O07147|MLCL581.14c|ML0452 PUTATIVE FT GLYCOSYLTRANSFERASE from Mycobacterium leprae (374 aa), FT FASTA scores: opt: 2044, E(): 8.8e-118, (82.25% identity in FT 378 aa overlap). N-terminus (from aa 1 to 27) equivalent to FT Q9FY7 PUTATIVE ALPHA-MANNOSYL TRANSFERASE (FRAGMENT) from FT Mycobacterium smegmatis (27 aa), BLASTP scores: 57.4 bits FT (137), E(): 3e-8, Identities = 25/27 (92%), Positives = FT 27/27 (99%) (see citation below). Also highly similar to FT Q9L284|SCL2.15c PUTATIVE SUGAR TRANSFERASE from FT Streptomyces coelicolor (387 aa), FASTA scores: opt: 1222, FT E(): 1.8e-67, (52.95% identity in 376 aa overlap); and FT similar in part to various proteins e.g. Q9YA73|APE2066 FT LONG HYPOTHETICAL N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL FT BIOSYNTHETIC PROTEIN from Aeropyrum pernix (392 aa), FASTA FT scores: opt: 434, E(): 3e-19, (31.5% identity in 378 aa FT overlap); Q9UZA1|PAB0827 GALACTOSYLTRANSFERASE OR LPS FT BIOSYNTHESIS RFBU RELATED PROTEIN from Pyrococcus abyssi FT (371 aa), FASTA scores: opt: 382, E(): 4.3e-16, (28.2% FT identity in 383 aa overlap); O26275|MTH173 LPS BIOSYNTHESIS FT RFBU RELATED PROTEIN from Methanothermobacter FT thermautotrophicus (382 aa), FASTA scores: opt: 372, E(): FT 1.8e-15, (28.4% identity in 391 aa overlap); etc. Shows FT also some similarity with O05313|Rv1212c|MTCI364.24c FT HYPOTHETICAL 41.5 KDA PROTEIN from Mycobacterium FT tuberculosis (387 aa), FASTA scores: opt: 232, E(): 1.1e FT -07, (28.4% identity in 402 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:O06204" FT /db_xref="InterPro:IPR001296" FT /db_xref="UniProtKB/Swiss-Prot:O06204" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08632.1" FT /translation="MRIGMICPYSFDVPGGVQSHVLQLAEVMRTRGHLVSVLAPASPHA FT ALPDYFVSGGRAVPIPYNGSVARLRFGPATHRKVKKWLAHGDFDVLHLHEPNAPSLSML FT ALNIAEGPIVATFHTSTTKSLTLTVFQGILRPMHEKIVGRIAVSDLARRWQMEALGSDA FT VEIPNGVDVDSFASAARLDGYPRQGKTVLFLGRYDEPRKGMAVLLDALPKVVQRFPDVQ FT LLIVGHGDADQLRGQAGRLAAHLRFLGQVDDAGKASAMRSADVYCAPNTGGESFGIVLV FT EAMAAGTAVVASDLDAFRRVLRDGEVGHLVPVDPPDLQAAALADGLIAVLENDVLRERY FT VAAGNAAVRRYDWSVVASQIMRVYETVAGSGAKVQVAS" FT misc_feature complement(165396..165419) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(165976..166926) FT /transl_table=11 FT /locus_tag="Rv2611c" FT /product="PROBABLE ACYLTRANSFERASE" FT /function="THE PRODUCT OT THIS PUTATIVE ORF SEEMS BE AN FT ACYLTRANSFERASE RESPONSIBLE FOR THE CLEAVAGE OF ONE FATTY FT ACID CHAIN OF PI (MOST LIKELY THE C16 FATTY ACID CHAIN FT FOUND AT POSITION sn-2) AND THUS INVOLVED IN THE SYNTHESIS FT OF LYSO-PIMan2, A POSSIBLE PRECURSOR OF LM AND FT LIPOARABINOMANNAN." FT /EC_number="2.3.1.-" FT /note="Rv2611c, (MTCY01A10.22), len: 316 aa. Probable FT acyltransferase (EC 2.3.1.-) , equivalent to FT O07148|MLCL581.15c|ML0453 HYPOTHETICAL 35.4 KDA PROTEIN FT from Mycobacterium leprae (320 aa), FASTA scores: opt: FT 1529, E(): 5e-90, (71.45% identity in 312 aa overlap); and FT equivalent to Q9F7Y8 PUTATIVE ACYLTRANSFERASE from FT Mycobacterium smegmatis (303 aa), FASTA scores: opt: 1464, FT E(): 6.5e-86, (72.15% identity in 291 aa overlap) (see FT citation below). Also highly similar to Q9L283|SCL2.16c FT PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (311 FT aa), FASTA scores: opt: 810, E(): 2.8e-44, (47.7% identity FT in 302 aa overlap); and similar to other acyltransferases FT e.g. Q9F0N3 ACYLTRANSFERASE from Campylobacter jejuni (295 FT aa), FASTA scores: opt: 207, E(): 6.4e-06, (20.45% identity FT in 220 aa overlap); Q9K379 ACYLTRANSFERASE (LIPID A FT BIOSYNTHESIS ACYLTRANSFERASE) from Campylobacter jejuni FT (295 aa), FASTA scores: opt: 203, E(): 1.1e-05, (20.0% FT identity in 220 aa overlap); etc." FT /db_xref="GOA:O06203" FT /db_xref="InterPro:IPR004960" FT /db_xref="UniProtKB/TrEMBL:O06203" FT /protein_id="CAB08631.1" FT /translation="MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRNA FT FDTGARYFARHGGPEQLRKNLARVLGVPPAAVPDPLMCASLESYGRYWREVFRLPTINH FT RKLARQLDRVIGGLDHLDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAERLK FT PESLYQRFIDYRESLGFEVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTGVEVD FT FFGEPTRMPVGPAKLAVETGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAITQALAD FT RFAQNIAAHPADWHMLQPQWLADLSESRRAQLRSR" FT CDS complement(166923..167576) FT /transl_table=11 FT /gene="pgsA1" FT /locus_tag="Rv2612c" FT /standard_name="pgsA" FT /product="PROBABLE PI SYNTHASE PGSA1 (PHOSPHATIDYLINOSITOL FT SYNTHASE) FT (CDP-DIACYLGLYCEROL--INOSITOL3-PHOSPHATIDYLTRANSFERASE)" FT /function="CATALYZES THE TRANSFER OF A FREE ALCOHOL FT (INOSITOL) ONTO CDP-DIACYLGLYCEROL. THE PRODUCT OF THIS FT PUTATIVE ORF SEEMS BE ESSENTIAL TO MYCOBACTERIA [CATALYTIC FT ACTIVITY: CDP-DIACYLGLYCEROL + MYO-INOSITOL = CMP + FT PHOSPHATIDYL 1D-MYO-INOSITOL]." FT /EC_number="2.7.8.11" FT /note="Rv2612c, (MTCY01A10.21), len: 217 aa. Probable pgsA1 FT (previously known as pgsA), PI FT synthase/CDP-diacylglyceride--inositol FT phosphatidyltransferase (EC 2.7.8.11), transmembrane FT protein, equivalent to O07149|MLCL581.16c|PGSA|ML0454 FT PUTATIVE PHOSPHATIDYLTRANSFERASE from Mycobacterium leprae FT (239 aa), FASTA scores: opt: 1141, E(): 4.1e-70, (79.35% FT identity in 213 aa overlap); and Q9F7Y9|PGSA FT PHOSPHATIDYLINOSITOL SYNTHASE from Mycobacterium smegmatis FT (222 aa), FASTA scores: opt: 981, E(): 2.7e-59, (67.3% FT identity in 217 aa overlap) (see citation below). Also FT similar to other proteins e.g. Q9L282|SCL2.17c PUTATIVE FT MEMBRANE TRANSFERASE from Streptomyces coelicolor (241 aa), FT FASTA scores: opt: 564, E(): 4.9e-31, (43.4% identity in FT 212 aa overlap); Q9UYD0|PGSA-LIKE|PAB1041 FT CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE FT 3-PHOSPHATIDYLTRANSFERASE from Pyrococcus abyssi (186 aa), FT FASTA scores: opt: 264, E(): 8.4e-11, (33.15% identity in FT 190 aa overlap); Q9HQS2|PGSA|VNG1030G FT CDP-DIACYLGLYCEROL-GLYCEROL-3-PHOSPHATE FT 3-PHOSPHATIDYLTRANSFERASE from Halobacterium sp. strain FT NRC-1 (199 aa), FASTA scores: opt: 249, E(): 9.1e-10, FT (32.1% identity in 193 aa overlap); etc. Contains PS00379 FT CDP-alcohol phosphatidyltransferases signature. BELONGS TO FT THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. FT Note that in Mycobacterium smegmatis, the psgA homologue is FT essential to the survival of the bacteria and seems cannot FT be compensated by any other enzyme of Mycobacterium FT smegmatis." FT /db_xref="GOA:Q7D6W6" FT /db_xref="InterPro:IPR000462" FT /db_xref="UniProtKB/TrEMBL:Q7D6W6" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="CAE55505.1" FT /translation="MSKLPFLSRAAFARITTPIARGLLRVGLTPDVVTILGTTASVAGA FT LTLFPMGKLFAGACVVWFFVLFDMLDGAMARERGGGTRFGAVLDATCDRISDGAVFCGL FT LWWIAFHMRDRPLVIATLICLVTSQVISYIKARAEASGLRGDGGFIERPERLIIVLTGA FT GVSDFPFVPWPPALSVGMWLLAVASVITCVQRLHTVWTSPGAIDRMAIPGKGDR" FT misc_feature complement(167298..167366) FT /note="PS00379 CDP-alcohol phosphatidyltransferases FT signature" FT CDS complement(167573..168160) FT /transl_table=11 FT /locus_tag="Rv2613c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN; BUT COULD BE INVOLVED IN LIPID FT METABOLISM." FT /note="Rv2613c, (MTCY01A10.20A), len: 195 aa. Conserved FT hypothetical protein, equivalent to Q9CCU0|ML0455 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (206 aa), FT FASTA scores: opt: 1074, E(): 7.4e-62, (84.7% identity in FT 196 aa overlap); and highly similar, but longer 18 aa, to FT O07150|MLCL581.17c HYPOTHETICAL 20.7 KDA PROTEIN from FT Mycobacterium leprae (186 aa), FASTA scores: opt: 1038, FT E(): 1.4e-59, (89.7% identity in 175 aa overlap). Also FT highly similar to other hypothetical proteins (often Hit FT family member) e.g. Q9F7Z0 from Mycobacterium smegmatis FT (see citation below) (205 aa), FASTA scores: opt: 975, E(): FT 1.6e-55, (79.35% identity in 184 aa overlap); FT Q9L279|SCL2.20 from Streptomyces coelicolor (186 aa), FASTA FT scores: opt: 638, E(): 5.8e-34, (52.85% identity in 176 aa FT overlap); Q9YFX8|APE0122 from Aeropyrum pernix (184 aa), FT FASTA scores: opt: 515, E(): 4.4e-26, (45.9% identity in FT 159 aa overlap); etc. It seems the Rv2613c and downstream FT ORF Rv2612c|psgA1 are expressed from the same promoter (see FT citation below) and that Rv2613c should be involved in FT lipid metabolism." FT /db_xref="GOA:O06201" FT /db_xref="HSSP:1FIT" FT /db_xref="InterPro:IPR011151" FT /db_xref="UniProtKB/TrEMBL:O06201" FT /protein_id="CAB08629.1" FT /translation="MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVK FT RDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELE FT DLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGD FT ANFITIIGGSKVIPQLLRDTRRLLATEWARQP" FT CDS complement(168153..170231) FT /transl_table=11 FT /gene="thrS" FT /locus_tag="Rv2614c" FT /product="PROBABLE THREONYL-TRNA SYNTHETASE THRS FT (THREONINE-TRNA SYNTHETASE)(ThrRS) (THREONINE-TRNA LIGASE)" FT /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC FT ACTIVITY: ATP + L-THREONINE + TRNA(THR) = AMP + FT PYROPHOSPHATE + L-THREONYL-TRNA(THR)]." FT /EC_number="6.1.1.3" FT /note="Rv2614c, (MT2689, MTCY01A10.20), len: 692 aa. FT Probable thrS, threonyl-tRNA synthetase (Threonine--tRNA FT ligase) (EC 6.1.1.3), equivalent to FT O07151|SYT_MYCLE|THRS|ML0456|MLCL581.18c THREONYL-TRNA FT SYNTHETASE from Mycobacterium leprae (702 aa), FASTA FT scores: opt: 3988, E(): 0, (84.05% identity in 702 aa FT overlap). Also highly similar to others e.g. Q9L278|THRS FT from Streptomyces coelicolor (658 aa), FASTA scores: opt: FT 1982, E(): 5.1e-114, (65.1% identity in 659 aa overlap); FT P56881|SYT_THETH|THRS from Thermus aquaticus (subsp. FT thermophilus) (659 aa), FASTA scores: opt: 1551, E(): FT 1.5e-87, (46.5% identity in 650 aa overlap); FT P00955|SYT_ECOLI from Escherichia coli (642 aa), FASTA FT scores: opt: 946, E(): 0, (40.7% identity in 612 aa overl FT ap); etc. Contains PS00339 Aminoacyl-transfer RNA FT synthetases class-II signature 2. BELONGS TO CLASS-II FT AMINOACYL-TRNA SYNTHETASE FAMILY. COFACTOR: BINDS 1 ZINC FT ION (BY SIMILARITY)." FT /db_xref="GOA:P67582" FT /db_xref="HSSP:1EVL" FT /db_xref="InterPro:IPR012947" FT /db_xref="UniProtKB/Swiss-Prot:P67582" FT /protein_id="CAB08628.1" FT /translation="MSAPAQPAPGVDGGDPSQARIRVPAGTTAATAVGEAGLPRRGTPD FT AIVVVRDADGNLRDLSWVPDVDTDITPVAANTDDGRSVIRHSTAHVLAQAVQELFPQAK FT LGIGPPITDGFYYDFDVPEPFTPEDLAALEKRMRQIVKEGQLFDRRVYESTEQARAELA FT NEPYKLELVDDKSGDAEIMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTKHIPAF FT KLTRSSAAYWRGDQKNASLQRIYGTAWESQEALDRHLEFIEEAQRRDHRKLGVELDLFS FT FPDEIGSGLAVFHPKGGIVRRELEDYSRRKHTEAGYQFVNSPHITKAQLFHTSGHLDWY FT ADGMFPPMHIDAEYNADGSLRKPGQDYYLKPMNCPMHCLIFRARGRSYRELPLRLFEFG FT TVYRYEKSGVVHGLTRVRGLTMDDAHIFCTRDQMRDELRSLLRFVLDLLADYGLTDFYL FT ELSTKDPEKFVGAEEVWEEATTVLAEVGAESGLELVPDPGGAAFYGPKISVQVKDALGR FT TWQMSTIQLDFNFPERFGLEYTAADGTRHRPVMIHRALFGSIERFFGILTEHYAGAFPA FT WLAPVQVVGIPVADEHVAYLEEVATQLKSHGVRAEVDASDDRMAKKIVHHTNHKVPFMV FT LAGDRDVAAGAVSFRFGDRTQINGVARDDAVAAIVAWIADRENAVPTAELVKVAGRE" FT misc_feature complement(168537..168566) FT /note="PS00339 Aminoacyl-transfer RNA synthetases class-II FT signature 2" FT CDS 170340..170567 FT /transl_table=11 FT /locus_tag="Rv2614A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2614A, len: 75 aa. Conserved hypothetical protein. FT The region from aa 10-35 is similar to part of C-terminal FT part of several TRIOSEPHOSPHATE ISOMERASES (EC 5.3.1.1) FT e.g. P46711|TPIS_MYCLE|TPIA|TPI|ML0572|B1496_C1_127 from FT Mycobacterium leprae (261 aa), FASTA scores: opt: 112, E(): FT 0.95, (60.0% identity in 25 aa overlap); and FT O08408|TPIS_MYCTU|TPIA|TPI|Rv1438|MT1482|MTCY493.16c from FT Mycobacterium tuberculosis (261 aa), FASTA scores: opt: FT 104, E(): 3.3, (60.0% identity in 25 aa overlap); FT P19583|TPIS_CORGL|TPIA|TPI from Corynebacterium glutamicum FT (Brevibacterium flavum) (259 aa), FASTA scores: opt: 100, FT E(): 6, (45.45% identity in 33 aa overlap); etc. FT TRIOSEPHOSPHATE ISOMERASES PLAY AN IMPORTANT ROLE IN FT SEVERAL METABOLIC PATHWAYS (CATALYTIC ACTIVITY: FT D-GLYCERALDEHYDE 3-PHOSPHATE = DIHYDROXY-ACETONE FT PHOSPHATE)." FT /db_xref="UniProtKB/TrEMBL:Q79FC4" FT /protein_id="CAE55506.1" FT /translation="MGDRYRAGDRVLYGGSMSPKDVDDLATQQDVDDGQSIERRWTGSG FT QRRWRRSPPTGRYRSNSQIQVWISGAGRLR" FT CDS complement(170564..171949) FT /transl_table=11 FT /gene="PE_PGRS45" FT /locus_tag="Rv2615c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2615c, (MTCY01A10.19), len: 461 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT many e.g. P71664|Rv1396c|MTCY21B4.13c from Mycobacterium FT tuberculosis (576 aa), FASTA scores: opt: 1629, E(): FT 4.8e-58, (56.65% identity in 482 aa overlap). Equivalent to FT AAK47006 from Mycobacterium tuberculosis strain CDC1551 FT (476 aa) but shorter 15 aa." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FC3" FT /protein_id="CAE55507.1" FT /translation="MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDE FT VSTAIAALFGSHGQHYQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLDAI FT NAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIG FT NGGAGGAGGQGLPFEAGANGGAGGAGGWLFGNGGAGGNGGIGGAGTNLAIGGHGGNGGN FT AGLIGAGGTGGAGGTGGGEPSAGASGGNGGNGGNGGLLIGNSGDGGAAGNGAGISQNGP FT ASGFGGNGGHAGTTGLIGNGGNGGAGGAGGDVSADFGGVGFGGQGGNGGAGGLLYGNGG FT AGGNGGAAGSPGSVTAFGGNGGSGGSGGNGGNALIGNAGAGGSAGAGGNGASAGTAGGS FT GGDGGKGGNGGSVGLIGNGGNGGNGGAGSLFNGAPGFGGPGGSGGASLLGPPGLAGTNG FT ADG" FT CDS 172294..172794 FT /transl_table=11 FT /locus_tag="Rv2616" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2616, (MTCY01A10.18c), len: 166 aa. Conserved FT hypothetical protein, highly similar to bacterial proteins: FT Q9L1G0|SC3D11.02c HYPOTHETICAL 20.3 KDA PROTEIN from FT Streptomyces coelicolor (188 aa), FASTA scores: opt: 407, FT E(): 2.3e-20, (44.0% identity in 159 aa overlap); Q9X945 FT A3(2) GLYCOGEN METABOLISM CLUSTER from Streptomyces FT coelicolor (134 aa), FASTA scores: opt: 330, E(): 2.5e-15, FT (46.65% identity in 120 aa overlap) (N-terminus shorter); FT Q9RST8|DR2035 CONSERVED HYPOTHETICAL PROTEIN from FT Deinococcus radiodurans (198 aa), FASTA scores: opt: 228, FT E(): 2.4e-08, (35.1% identity in 168 aa overlap)." FT /db_xref="InterPro:IPR018960" FT /db_xref="UniProtKB/TrEMBL:O06198" FT /protein_id="CAB08626.1" FT /translation="MDLNALADLPLTYPEVGATATGRLPAGYNHLDVSTQIGTGRQRFE FT QAADAVMHWGMQRNAGLRVRASSETAVVSAVVLVGIAFLRAPCRVVYVIDEPDVRGFGY FT GTLPGHPVSGEERFAVRCDPMTSVVFAEVLSFSRPATWASKAAGPLGAVTQRFIAQRYL FT RAV" FT CDS complement(172811..173251) FT /transl_table=11 FT /locus_tag="Rv2617c" FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2617c, (MTCY01A10.17), len: 146 aa. Probable FT transmembrane protein, showing some similarity to FT hypothetical or membrane proteins e.g. CAC47207|SMC00744 FT PUTATIVE TRANSPORT PROTEIN TRANSMEMBRANE from Rhizobium FT meliloti (Sinorhizobium meliloti) (399 aa), FASTA scores: FT opt: 108, E(): 5.5, (29.15% identity in 144 aa overlap)." FT /db_xref="GOA:O06197" FT /db_xref="UniProtKB/TrEMBL:O06197" FT /protein_id="CAB08625.1" FT /translation="MSIRPTTSPALADQLKDPAYSAYVLLRTLFTVAPILFGLDKFFNL FT LTHPQHWNMYLAGWINDLVPGTADQCMYLVGAIEIVAGVLVAVAPRIGAWVVAAWLAGI FT ILNLVTGPGFYDIALRDFGLLVGAIALARLAQGVHSGGIGRP" FT CDS 173398..174075 FT /transl_table=11 FT /locus_tag="Rv2618" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2618, (MTCY01A10.15c), len: 225 aa. Conserved FT hypothetical protein, similar in part to Q9EWQ9|SC4C2.03 FT CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor FT (159 aa), FASTA scores: opt: 235, E(): 1.3e-07, (43.7% FT identity in 103 aa overlap); Q9HLM6|TA0201 HYPOTHETICAL FT PROTEIN from Thermoplasma acidophilum (215 aa), FASTA FT scores: opt: 164, E(): 0.0038, (23.4% identity in 201 aa FT overlap); and to mycobacterial proteins e.g. FT O06191|Rv2621c|MTCY01A10.11 HYPOTHETICAL 24.2 KDA PROTEIN FT from Mycobacterium tuberculosis (224 aa), FASTA scores: FT opt: 149, E(): 0.033, (28.05% identity in 196 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06195" FT /protein_id="CAB08624.1" FT /translation="MDPVRRQLYQFVCSQSMPVSRDQAADAVGIPRHQAKFHLDRLTAE FT GLLDTEYARLTGRSGPGAGRTAKLYRRAGRDIALSLPQREYELAGRLMAAAIVLSATTG FT EPTVEVLNRIAHDYGQAMGAAATTRPPADPAAALELTLDVLRKYGYEPRRPAGPGDDEV FT ELVNCPFHALAREQTELACNMNHALITGVADALAPHSPAVRLAPGPARCCVVLKRCSAH FT DPE" FT CDS complement(174060..174413) FT /transl_table=11 FT /locus_tag="Rv2619c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2619c, (MTCY01A10.14), len: 117 aa. Conserved FT hypothetical protein, highly similar to Q9L0F3|SCD31.14 FT HYPOTHETICAL 11.6 KDA PROTEIN from Streptomyces coelicolor FT (110 aa) , FASTA scores: opt: 407, E(): 2.3e-21, (55.95% FT identity in 109 aa overlap). Also similarity with other FT short bacterial hypothetical proteins e.g. Q9F8B9 FT HYPOTHETICAL 12.4 KDA PROTEIN from Streptococcus agalactiae FT (112 aa), FASTA scores: opt: 143, E(): 0.0032, (32.45% FT identity in 74 aa overlap); etc." FT /db_xref="UniProtKB/TrEMBL:O06194" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08623.1" FT /translation="MESISLTSLAAEKLAEAQQTHSGRAAHTIHGGHTHELRQTVLALL FT AGHDLSEHDSPGEATLQVLQGHVCLTAGEDAWNGRAGDYVAIPPTRHALHAVEDSVIML FT TVLKSLPDAHSGS" FT CDS complement(174426..174851) FT /transl_table=11 FT /locus_tag="Rv2620c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2620c, (MTCY01A10.13), len: 141 aa. Probable FT conserved transmembrane protein, highly similar to FT O54184|SC7H1.25 HYPOTHETICAL 14.6 KDA PROTEIN from FT Streptomyces coelicolor (144 aa), FASTA scores: opt: 459, FT E(): 1.4e-22, (56.45% identity in 140 aa overlap)." FT /db_xref="GOA:O06193" FT /db_xref="UniProtKB/TrEMBL:O06193" FT /protein_id="CAB08622.1" FT /translation="MSAGPAIEVAVAFVWLGMVVAISFLEAPLKFRAAGVTLQIGLGIG FT RLVFRALNTVEVGFALVILAIVVVGSTPARIAAAFSVALAALAVQLIAVRPRLTRRSNQ FT VLAGLQAPRSRGHHIYVGLEIVKVVALLVAGILLLNG" FT CDS complement(174848..175522) FT /transl_table=11 FT /locus_tag="Rv2621c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv2621c, (MTCY01A10.11), len: 224 aa. Possible FT transcriptional regulator, similar in part to FT Q49688|MLCL536.29c|ML0592 PUTATIVE DNA-BINDING PROTEIN from FT Mycobacterium leprae (254 aa), FASTA scores: opt: 168, E(): FT 0.0018, (29.75% identity in 222 aa overlap). Shows FT similarity with Q9XAD0|SCC22.08c PUTATIVE DNA-BINDING FT PROTEIN from Streptomyces coelicolor (252 aa), FASTA FT scores: opt: 148, E(): 0.032, (29.4% identity in 204 aa FT overlap); and Q9RVM8|DR0999 CONSERVED HYPOTHETICAL PROTEIN FT from Deinococcus radiodurans (225 aa), FASTA scores: opt: FT 195, E(): 3.3e-05, (29.6% identity in 213 aa overlap). Also FT some similarity with O06195|Rv2618|MTCY01A10.15c from FT Mycobacterium tuberculosis (225 aa), FASTA scores: opt: FT 149, E(): 0.025, (28.95% identity in 197 aa overlap). FT Contains helix-turn-helix motif at aa 31-52 (Score 1662, FT +4.85 SD)." FT /db_xref="UniProtKB/TrEMBL:O06191" FT /protein_id="CAB08621.1" FT /translation="MGVSVIIRSLQEPVGRRRAVLRALCASRVPMSIAAIAGKLGVHPN FT TVRFHLDNLVADGQVERVEPGRGRPGRPPLMFRAVRRTDSTGTRRYRLLAEILASGLAA FT ERDSRAMALSAGRAWGRQLEAPPAGADTEETIDHLVAVLDDLGFAPERRASNGRQQVGL FT RHCPFLELAETQAGVVCPVHLGIMRGALQTWGAPVTVDRLDAFVEPDLCLAHFTPLEGA FT IR" FT CDS 175600..176421 FT /transl_table=11 FT /locus_tag="Rv2622" FT /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" FT /function="CAUSES METHYLATION." FT /EC_number="2.1.1.-" FT /note="Rv2622, (MTCY01A10.10c), len: 273 aa. Possible FT methyltransferase (EC 2.1.1.-), similar in part to others FT e.g. AAK75664|SP1578 PUTATIVE METHYLTRANSFERASE from FT Streptococcus pneumoniae (252 aa), FASTA scores: opt: 406, FT E(): 6.6e-18, (32.65% identity in 251 aa overlap); Q9F8B8 FT METHYLTRANSFERASE from Streptococcus agalactiae (254 aa), FT FASTA scores: opt: 381, E(): 2.3e-16, (31.75% identity in FT 252 aa overlap); Q9RJB6|SCF91.08 PUTATIVE METHYLTRANSFERASE FT from Streptomyces coelicolor (231 aa), FASTA scores: opt: FT 159, E(): 0.0091, (33.1% identity in 151 aa overlap); etc. FT Also similar in part to several hypothetical proteins e.g. FT Q99YR0|SPY1582 HYPOTHETICAL PROTEIN from Streptococcus FT pyogenes (251 aa), FASTA scores: opt: 397, E(): 2.3e-17, FT (36.3% identity in 248 aa overlap)." FT /db_xref="GOA:O06190" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:O06190" FT /protein_id="CAB08620.1" FT /translation="MANKRGNAGQPLPLSDRDDDHMQGHWLLARLGKRVLRPGGVELTR FT TLLARAEVTDADVLELAPGLGRTAAEILARNPRSYVGAESDPNAANLVRHVLAGRGDVR FT VTDAADTGLSDASADVVIGEAMLTMQGNAAKHTIVAEAARVLRPGGRYAIHELALVPDD FT VAEQVRTDLRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTASMALLQPRRVIAD FT EGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAHKPHVDS" FT CDS 176557..177450 FT /transl_table=11 FT /gene="TB31.7" FT /locus_tag="Rv2623" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB31.7" FT /function="UNKNOWN" FT /note="Rv2623, (MTCY01A10.09c), len: 297 aa. TB31.7, FT conserved hypothetical protein, highly similar to FT hypothetical proteins from Mycobacterium tuberculosis e.g. FT Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa), FASTA FT scores: opt: 1076, E(): 1.4e-60, (55.25% identity in 295 aa FT overlap); O53472|Rv2026c|MTV018.13c (294 aa), FASTA scores: FT opt: 988, E(): 4.8e-55, (51.5% identity in 295 aa overlap); FT Q10862|YJ96_MYCTU|Rv1996|MT2052|MTCY39.23c (317 aa), FASTA FT scores: opt: 688, E(): 4.1e-36, (45.1% identity in 315 aa FT overlap); etc. Also similar to several Streptomyces FT proteins e.g. Q9RIZ8|SCJ1.16c CONSERVED HYPOTHETICAL FT PROTEIN from Streptomyces coelicolor (294 aa), FASTA FT scores: opt: 407, E(): 2e-18, (32.65% identity in 303 aa FT overlap); and other bacterial hypothetical proteins e.g. FT Q9HPP5|VNG1536 from Halobacterium sp (147 aa), FASTA FT scores: opt: 180, E(): 0.00022, (31.65% identity in 139 aa FT overlap)." FT /db_xref="GOA:O06189" FT /db_xref="InterPro:IPR006015" FT /db_xref="PDB:2JAX" FT /db_xref="UniProtKB/TrEMBL:O06189" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08619.1" FT /translation="MSSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVS FT PEVATWLEVPLPPGVLRWQQDHGRHLIDDALKVVEQASLRAGPPTVHSEIVPAAAVPTL FT VDMSKDAVLMVVGCLGSGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQAPVL FT VGVDGSSASELATAIAFDEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAE FT RLAGWQERYPNVAITRVVVRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETV FT AQLARTPVIVARESLT" FT CDS complement(177453..178271) FT /transl_table=11 FT /locus_tag="Rv2624c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2624c, (MTCY01A10.08), len: 272 aa. Conserved FT hypothetical protein, similar to several Streptomyces FT proteins e.g. Q9RIY5|SCJ1.29c HYPOTHETICAL 30.1 KDA PROTEIN FT from Streptomyces coelicolor (283 aa), FASTA scores: opt: FT 260, E(): 5e-09, (32.05% identity in 290 aa overlap). Also FT similar to Mycobacterium tuberculosis proteins FT O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 563, FT E(): 7e-28, (36.85% identity in 266 aa overlap); FT P95192|Rv3134c|MTCY03A2.240 (268 aa), FASTA scores: opt: FT 458, E(): 2.3e-21, (36.55% identity in 271 aa overlap); FT Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa), FASTA FT scores: opt: 199, E(): 3.2e-05, (29.35% identity in 286 aa FT overlap); etc." FT /db_xref="GOA:O06188" FT /db_xref="InterPro:IPR006015" FT /db_xref="UniProtKB/TrEMBL:O06188" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08618.1" FT /translation="MSGRGEPTMKTIIVGIDGSHAAITAALWGVDEAISRAVPLRLVSV FT IKPTHPSPDDYDRDLAHAERSLREAQSAVEAAGKLVKIETDIPRGPAGPVLVEASRDAE FT MICVGSVGIGRYASSILGSTATELAEKAHCPVAVMRSKVDQPASDINWIVVRMTDAPDN FT EAVLEYAAREAKLRQAPILALGGRPEELREIPDGEFERRVQDWHHRHPDVRVYPITTHT FT GIARFLADHDERVQLAVIGGGEAGQLARLVGPSGHPVFRHAECSVLVVRR" FT CDS complement(178286..179467) FT /transl_table=11 FT /locus_tag="Rv2625c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND FT LEUCINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2625c, (MTCY01A10.07), len: 393 aa. Probable FT conserved transmembrane ala-, leu-rich protein, similar to FT many hypothetical or membrane proteins e.g. FT Q55518|Y528_SYNY3|SLL0528 POTENTIAL INTEGRAL MEMBRANE FT PROTEIN from Synechocystis sp. strain PCC 6803 (379 aa), FT FASTA scores: opt: 552, E(): 5.6e-26, (30.75% identity in FT 374 aa overlap); Q9RJ56|SCI41.35c HYPOTHETICAL 39.8 KDA FT PROTEIN from Streptomyces coelicolor (374 aa), FASTA FT scores: opt: 419, E(): 5.7e-18, (31.6% identity in 383 aa FT overlap); CAC49448|SMB20925 CONSERVED HYPOTHETICAL MEMBRANE FT PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) FT (372 aa), FASTA scores: opt: 401, E(): 6.9e-17, (29.5% FT identity in 383 aa overlap); etc. Contains PS00142 Neutral FT zinc metallopeptidases, zinc-binding region signature." FT /db_xref="GOA:O06187" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:O06187" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08617.1" FT /translation="MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPA FT VVYWLLGAGGAVMLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKA FT AFRIAFAGPATSLALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAP FT LDGGRLVRAYLWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIG FT WFIFAAAREEETRISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYP FT VADRDGSITGLVALRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPL FT GPRSRALVTEGSAVVGIVTPSDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG" FT misc_feature complement(179252..179281) FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS complement(179526..179957) FT /transl_table=11 FT /locus_tag="Rv2626c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2626c, (MTCY01A10.06), len: 143 aa. Conserved FT hypothetical protein, similar to CAC49670|SMB21441 PUTATIVE FT INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE PROTEIN (EC FT 1.1.1.205) from Rhizobium meliloti (Sinorhizobium meliloti) FT (120 aa), FASTA scores: opt: 287, E(): 6.6e-12, (43.75% FT identity in 112 aa overlap) (has its N-terminus shorter 27 FT aa); AAK78655|CAC0678 CBS DOMAINS from Clostridium FT acetobutylicum (142 aa), FASTA scores: opt: 276, E(): FT 3.9e-11, (35.65% identity in 115 aa overlap); Q9K9P0|BH2605 FT BH2605 PROTEIN from Bacillus halodurans (142 aa), FASTA FT scores: opt: 276, E(): 3.9e-11, (35.65% identity in 115 aa FT overlap); etc. Also some similarity to FT P71737|Rv2406c|MTCY253.14 HYPOTHETICAL 15.1 KDA PROTEIN FT from Mycobacterium tuberculosis (142 aa), FASTA scores: FT opt: 145, E(): 0.00012, (22.3% identity in 112 aa FT overlap)." FT /db_xref="InterPro:IPR000644" FT /db_xref="PDB:1XKF" FT /db_xref="UniProtKB/TrEMBL:O06186" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08616.1" FT /translation="MTTARDIMNAGVTCVGEHETLTAAAQYMREHDIGALPICGDDDRL FT HGMLTDRDIVIKGLAAGLDPNTATAGELARDSIYYVDANASIQEMLNVMEEHQVRRVPV FT ISEHRLVGIVTEADIARHLPEHAIVQFVKAICSPMALAS" FT CDS complement(180471..181712) FT /transl_table=11 FT /locus_tag="Rv2627c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2627c, (MTCY01A10.05), len: 413 aa. Conserved FT hypothetical protein. Some similarity in C-terminal part of FT O53697|Rv0293c|MTV035.21c HYPOTHETICAL 44.0 KDA PROTEIN FT from Mycobacterium tuberculosis (400 aa), FASTA scores: FT opt: 392, E(): 1.9e-17, (31.1% identity in 299 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:O06185" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08637.1" FT /translation="MASSASDGTHERSAFRLSPPVLSGAMGPFMHTGLYVAQSWRDYLG FT QQPDKLPIARPTIALAAQAFRDEIVLLGLKARRPVSNHRVFERISQEVAAGLEFYGNRR FT WLEKPSGFFAQPPPLTEVAVRKVKDRRRSFYRIFFDSGFTPHPGEPGSQRWLSYTANNR FT EYALLLRHPEPRPWLVCVHGTEMGRAPLDLAVFRAWKLHDELGLNIVMPVLPMHGPRGQ FT GLPKGAVFPGEDVLDDVHGTAQAVWDIRRLLSWIRSQEEESLIGLNGLSLGGYIASLVA FT SLEEGLACAILGVPVADLIELLGRHCGLRHKDPRRHTVKMAEPIGRMISPLSLTPLVPM FT PGRFIYAGIADRLVHPREQVTRLWEHWGKPEIVWYPGGHTGFFQSRPVRRFVQAALEQS FT GLLDAPRTQRDRSA" FT CDS 182022..182384 FT /transl_table=11 FT /locus_tag="Rv2628" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2628, (MTCY01A10.04c), len: 120 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O06184" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08635.1" FT /translation="MSTQRPRHSGIRAVGPYAWAGRCGRIGRWGVHQEAMMNLAIWHPR FT KVQSATIYQVTDRSHDGRTARVPGDEITSTVSGWLSELGTQSPLADELARAVRIGDWPA FT AYAIGEHLSVEIAVAV" FT CDS 182731..183855 FT /transl_table=11 FT /locus_tag="Rv2629" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2629, (MTCY01A10.03c), len: 374 aa. Conserved FT hypothetical protein, similar to Q9ZC00|SC1E6.22c FT HYPOTHETICAL 40.7 KDA PROTEIN from Streptomyces coelicolor FT (373 aa), FASTA scores: opt: 425, E(): 2.5e-18, (30.2% FT identity in 371 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06183" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08634.1" FT /translation="MRSERLRWLVAAEGPFASVYFDDSHDTLDAVERREATWRDVRKHL FT ESRDAKQELIDSLEEAVRDSRPAVGQRGRALIATGEQVLVNEHLIGPPPATVIRLSDYP FT YVVPLIDLEMRRPTYVFAAVDHTGADVKLYQGATISSTKIDGVGYPVHKPVTAGWNGYG FT DFQHTTEEAIRMNCRAVADHLTRLVDAADPEVVFVSGEVRSRTDLLSTLPQRVAVRVSQ FT LHAGPRKSALDEEEIWDLTSAEFTRRRYAEITNVAQQFEAEIGRGSGLAAQGLAEVCAA FT LRDGDVDTLIVGELGEATVVTGKARTTVARDADMLSELGEPVDRVARADEALPFAAIAV FT GAALVRDDNRIAPLDGVGALLRYAATNRLGSHRS" FT CDS 183857..184396 FT /transl_table=11 FT /locus_tag="Rv2630" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2630, (MTCY01A10.02c), len: 179 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR002804" FT /db_xref="UniProtKB/TrEMBL:O06182" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08633.1" FT /translation="MLHRDDHINPPRPRGLDVPCARLRATNPLRALARCVQAGKPGTSS FT GHRSVPHTADLRIEAWAPTRDGCIRQAVLGTVESFLDLESAHAVHTRLRRLTADRDDDL FT LVAVLEEVIYLLDTVGETPVDLRLRDVDGGVDVTFATTDASTLVQVGAVPKAVSLNELR FT FSQGRHGWRCAVTLDV" FT CDS 184536..185834 FT /transl_table=11 FT /locus_tag="Rv2631" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2631, (MTCY441.01, MTCY01A10.01c), len: 432 aa. FT Conserved hypothetical protein, highly similar to several FT conserved hypothetical proteins from various species e.g. FT O29399|AF0862 CONSERVED HYPOTHETICAL PROTEIN from FT Archaeoglobus fulgidus (482 aa), FASTA scores: opt: 1496, FT E(): 2.1e-80, (52.3% identity in 432 aa overlap) (has its FT N-terminus longer 30 aa); O27634|MTH1597 CONSERVED PROTEIN FT from Methanothermobacter thermautotrophicus (488 aa), FASTA FT scores: opt: 1428, E(): 2.1e-76, (50.9% identity in 432 aa FT overlap); Q9YB37|APE1758 HYPOTHETICAL 53.7 KDA PROTEIN FT APE1758 from Aeropyrum pernix (483 aa), FASTA scores: opt: FT 1422, E(): 4.6e-76, (49.3% identity in 432 aa overlap) (has FT its N-terminus longer 30 aa); etc. Equivalent to AAK47022 FT from Mycobacterium tuberculosis strain CDC1551 (432 aa). 3' FT part extended since first submission (+175 aa)." FT /db_xref="InterPro:IPR001233" FT /db_xref="UniProtKB/Swiss-Prot:P71930" FT /protein_id="CAB02365.2" FT /translation="MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVVS FT PGGVGFDISCGVRLLVGEGLDREELQPRLPAVMDRLDRAIPRGVGTAGVWRLPDRNTLQ FT EVLTGGARFAVEQGHGVALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSGNHF FT LEVQAVDRVYDPVAAAPMGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRYGIAV FT PDRQLACVPVHSPDGQAYLAAMAAAANYGRANRQLLTEATRRVFADATGTPLDLLYDVS FT HNLAKIETHPIDGQLRSVCVHRKGATRSLPPHHHELPAELAAVGQPVLIPGTMGTASYV FT LAGVTGNPAFFSTAHGAGRVLSRHQAARHTSGEAIRASLAKRGIIVRGTSRRGIAEEKP FT EAYKDVDEVIEASHQSGLARKVARLVPLGCVKG" FT CDS complement(185873..186154) FT /transl_table=11 FT /locus_tag="Rv2632c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2632c, (MTCY441.02c), len: 93 aa. Conserved FT hypothetical protein, highly similar to conserved FT hypothetical proteins from Mycobacterium tuberculosis: FT P71996|YH38_MYCTU|Rv1738|MT1780|MTCY04C12.23 (94 aa), FASTA FT scores: opt: 319, E(): 4.2e-15, (53.95% identity in 89 aa FT overlap); and Q9KK61 from Mycobacterium bovis BCG (56 aa), FT FASTA scores: opt: 178, E(): 9.2e-06, (52.95% identity in FT 51 aa overlap)." FT /db_xref="InterPro:IPR015057" FT /db_xref="PDB:2FGG" FT /db_xref="UniProtKB/Swiss-Prot:P65033" FT /protein_id="CAB02340.1" FT /translation="MTDSEHVGKTCQIDVLIEEHDERTRAKARLSWAGRQMVGVGLARL FT DPADEPVAQIGDELAIARALSDLANQLFALTSSDIEASTHQPVTGLHH" FT CDS complement(186299..186784) FT /transl_table=11 FT /locus_tag="Rv2633c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2633c, (MTCY441.03c), len: 161 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR012312" FT /db_xref="UniProtKB/Swiss-Prot:P65035" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02352.1" FT /translation="MNAYDVLKRHHTVLKGLGRKVGEAPVNSEERHVLFDEMLIELDIH FT FRIEDDLYYPALSAAGKPITGTHAEHRQVVDQLATLLRTPQRAPGYEEEWNVFRTVLEA FT HADVEERDMIPAPTPVHITDAELEELGDKMAARIEQLRGSPLYTLRTKGKADLLKAI" FT CDS complement(187069..189405) FT /transl_table=11 FT /gene="PE_PGRS46" FT /locus_tag="Rv2634c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2634c, (MTCY441.04c), len: 778 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT many e.g. O53553|YZ08_MYCTU|Rv3508|MTV023.15 from FT Mycobacterium tuberculosis (1901 aa), FASTA scores: opt: FT 2553, E(): 2.2e-93, (53.8% identity in 866 aa overlap). FT Equivalent to AAK47026 from Mycobacterium tuberculosis FT strain CDC1551 (788 aa) but shorter 10 aa." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:P0A690" FT /protein_id="CAE55508.1" FT /translation="MSFVIAVPEALTMAASDLANIGSTINAANAAAALPTTGVVAAAAD FT EVSAAVAALFGSYAQSYQAFGAQLSAFHAQFVQSLTNGARSYVVAEATSAAPLQDLLGV FT VNAPAQALLGRPLIGNGANGADGTGAPGGPGGLLLGNGGNGGSGAPGQPGGAGGDAGLI FT GNGGTGGKGGDGLVGSGAAGGVGGRGGWLLGNGGTGGAGGAAGATLVGGTGGVGGATGL FT IGSGGFGGAGGAAAGVGTTGGVGGSGGVGGVFGNGGFGGAGGLGAAGGVGGAASYFGTG FT GGGGVGGDGAPGGDGGAGPLLIGNGGVGGLGGAGAAGGNGGAGGMLLGDGGAGGQGGPA FT VAGVLGGMPGAGGNGGNANWFGSGGAGGQGGTGLAGTNGVNPGSIANPNTGANGTDNSG FT NGNQTGGNGGPGPAGGVGEAGGVGGQGGLGESLDGNDGTGGKGGAGGTAGTDGGAGGAG FT GAGGIGETDGSAGGVATGGEGGDGATGGVDGGVGGAGGKGGQGHNTGVGDAFGGDGGIG FT GDGNGALGAAGGNGGTGGAGGNGGRGGMLIGNGGAGGAGGTGGTGGGGAAGFAGGVGGA FT GGEGLTDGAGTAEGGTGGLGGLGGVGGTGGMGGSGGVGGNGGAAGSLIGLGGGGGAGGV FT GGTGGIGGIGGAGGNGGAGGAGTTTGGGATIGGGGGTGGVGGAGGTGGTGGAGGTTGGS FT GGAGGLIGWAGAAGGTGAGGTGGQGGLGGQGGNGGNGGTGATGGQGGDFALGGNGGAGG FT AGGSPGGSSGIQGNMGPPGTQGADG" FT CDS 189434..189676 FT /transl_table=11 FT /locus_tag="Rv2635" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2635, (MTCY441.05), len: 80 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P65037" FT /protein_id="CAB02342.1" FT /translation="MVAADHRALGSNKSYPASQTAEAIWPPARTLRYDRQSPWLATGFD FT RRMSQTVTGVGVQNCAVSKRRCSAVDHSSRTPYRR" FT CDS 189677..190354 FT /transl_table=11 FT /locus_tag="Rv2636" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2636, (MTCY441.06), len: 225 aa. Conserved FT hypothetical protein, showing some similarity with various FT proteins: Q98FG2|MLL3789 HYPOTHETICAL PROTEIN from FT Rhizobium loti (Mesorhizobium loti) (239 aa), FASTA scores: FT opt: 304, E(): 3.7e-13, (31.55% identity in 187 aa FT overlap); CAC46568|SMC04451 PUTATIVE CHLORAMPHENICOL FT PHOSPHOTRANSFERASE PROTEIN from Rhizobium meliloti FT (Sinorhizobium meliloti) (220 aa), FASTA scores: opt: 175, FT E(): 0.00014, (28.0% identity in 225 aa overlap); FT Q56148|CPT_STRVL CHLORAMPHENICOL 3-O PHOSPHOTRANSFERASE (EC FT 2.7.1.-) from Streptomyces violaceus (Streptomyces FT venezuelae) (178 aa), FASTA scores: opt: 131, E(): 0.1, FT (31.75% identity in 170 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). Translational start FT site uncertain, chosen by similarity." FT /db_xref="GOA:P65039" FT /db_xref="HSSP:1QHX" FT /db_xref="InterPro:IPR012853" FT /db_xref="UniProtKB/Swiss-Prot:P65039" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02353.1" FT /translation="MINPTRARRMRYRLAAMAGMPEGKLILLNGGSSAGKTSLALAFQD FT LAAECWMHIGIDLFWFALPPEQLDLARVRPEYYTWDSAVEADGLEWFTVHPGPILDLAM FT HSRYRAIRAYLDNGMNVIADDVIWTREWLVDALRVFEGCRVWMVGVHVSDEEGARRELE FT RGDRHPGWNRGSARAAHADAEYDFELDTTATPVHELARELHESYQACPYPMAFNRLRKR FT FLS" FT misc_feature 189764..189787 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 190550..191206 FT /transl_table=11 FT /gene="dedA" FT /locus_tag="Rv2637" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN DEDA" FT /function="UNKNOWN" FT /note="Rv2637, (MTCY441.07), len: 218 aa. Possible dedA, FT transmembrane protein, equivalent to FT Q49642|YQ37_MYCLE|ML0467|MLCL581.27|B1177_C2_172/B1177_C1 FT _1 40 HYPOTHETICAL 23.1 KDA PROTEIN (POTENTIAL INTEGRAL FT MEMBRANE PROTEIN, BELONGS TO THE DEDA FAMILY) from FT Mycobacterium leprae (214 aa), FASTA scores: opt: 1160, FT E(): 4.4e-64, (82.75% identity in 209 aa overlap); and FT O69601|Y364_MYCLE|ML0287|MLCB4.30 HYPOTHETICAL PROTEIN FT (POTENTIAL INTEGRAL MEMBRANE PROTEIN) (222 aa), FASTA FT scores: opt: 292, E(): 6.6e-11, (32.25% identity in 189 aa FT overlap). Also highly similar to other membrane proteins FT e.g. CAC42863|SCBAC36F5.27c PUTATIVE INTEGRAL MEMBRANE from FT Streptomyces coelicolor (211 aa), FASTA scores: opt: 837, FT E(): 2.6e-44, (59.2% identity in 201 aa overlap); FT Q55705|Y232_SYNY3|SLR0232 POTENTIAL INTEGRAL MEMBRANE FT PROTEIN from Synechocystis sp. strain PCC 6803 (218 aa), FT FASTA scores: opt: 415, E(): 1.9e-18, (37.85% identity in FT 206 aa overlap); Q9RV63|DR1167 DEDA PROTEIN from FT Deinococcus radiodurans (200 aa); FT P09548|DEDA_ECOLI|B2317|Z3579|ECS3201 DEDA PROTEIN (DSG-1 FT PROTEIN) from Escherichia coli strains K12 and O157:H7 (219 FT aa), BLAST scores: 178, E(): 1.8e-13, Identities = 53/175 FT (30%); etc. Also similar to FT O06314|Y364_MYCTU|Rv0364|MT0380|MTCY13E10.26 HYPOTHETICAL FT 24.5 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from FT Mycobacterium tuberculosis (227 aa), FASTA scores: opt: FT 293, E(): 5.8e-11, (35.85% identity in 184 aa overlap). FT BELONGS TO THE DEDA FAMILY." FT /db_xref="GOA:P63911" FT /db_xref="InterPro:IPR015414" FT /db_xref="UniProtKB/Swiss-Prot:P63911" FT /protein_id="CAB02343.1" FT /translation="MDVEALLQSIPPLMVYLVVGAVVGIESLGIPLPGEIVLVSAAVLS FT SHPELAVNPIGVGGAAVIGAVVGDSIGYSIGRRFGLPLFDRLGRRFPKHFGPGHVALAE FT RLFNRWGVRAVFLGRFIALLRIFAGPLAGALKMPYPRFLAANVTGGICWAGGTTALVYF FT AGMAAQHWLERFSWIALVIAVIAGITAAILLRERTSRAIAELEAEHCRKAGTTAA" FT CDS 191369..191815 FT /transl_table=11 FT /locus_tag="Rv2638" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2638, (MTCY441.08), len: 147 aa. Conserved FT hypothetical protein, similar in part to FT Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR FT ANTAGONIST from Streptomyces coelicolor (113 aa), FASTA FT scores: opt: 162, E(): 0.00066, (31.8% identity in 110 aa FT overlap); and showing weak similarity with various proteins FT e.g. O69205 HYPOTHETICAL 13.4 KDA PROTEIN from FT Actinosynnema pretiosum (subsp. auranticum) (128 aa), FASTA FT scores: opt: 157, E(): 0.0016, (29.8% identity in 114 aa FT overlap); Q9RJ93|SCF91.32 PUTATIVE ANTI-SIGMA FACTOR FT ANTAGONIST from Streptomyces coelicolor (183 aa), FASTA FT scores: opt: 148, E(): 0.0082, (30.85% identity in 107 aa FT overlap); etc. Also highly similar to hypothetical proteins FT from Mycobacterium tuberculosis: O07728|Rv1904|MTCY180.14c FT (143 aa), FASTA scores: opt: 456, E(): 3.9e-23, (52.8% FT identity in 125 aa overlap); and FT Q11035|YD65_MYCTU|Rv1365c|MT1411|MTCY02B10.29c (128 aa), FT FASTA scores: opt: 435, E(): 8.6e-22, (53.6% identity in FT 125 aa overlap)." FT /db_xref="GOA:P71937" FT /db_xref="InterPro:IPR003658" FT /db_xref="UniProtKB/TrEMBL:P71937" FT /protein_id="CAB02344.1" FT /translation="MGLITTEPRSSPHPLSPRLVHELGDPHSTLRATTDGSGAALLIHA FT GGEIDGRNEHLWRQLVTEAAAGVTAPGPLIVDVTGLDFMGCCAFAALADEAQRCRCRGI FT DLRLVSHQPIVARIAEAGGLSRVLPIYPTVDTALGKGTAGPARC" FT CDS complement(191990..192322) FT /transl_table=11 FT /locus_tag="Rv2639c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2639c, (MTCY441.09c), len: 110 aa. Probable FT conserved integral membrane protein, highly similar to many FT bacterial hypothetical or membrane proteins e.g. FT Q9X889|YE14_STRCO|SCE15.14 POTENTIAL INTEGRAL MEMBRANE FT PROTEIN from Streptomyces coelicolor (112 aa), FASTA FT scores: opt: 597, E(): 3.1e-31, (73.15% identity in 108 aa FT overlap); Q55939|Y793_SYNY3|SLL0793 POTENTIAL INTEGRAL FT MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 FT (108 aa), FASTA scores: opt: 341, E(): 4.9e-15, (51.4% FT identity in 109 aa overlap); O31553|YFJF_BACSU POTENTIAL FT INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis (109 aa), FT FASTA scores: opt: 334, E(): 1.4e-14, (47.5% identity in FT 109 aa overlap); etc." FT /db_xref="GOA:P67146" FT /db_xref="InterPro:IPR003844" FT /db_xref="UniProtKB/Swiss-Prot:P67146" FT /protein_id="CAB02345.1" FT /translation="MVVRSILLFVLAAVAEIGGAWLVWQGVREQRGWLWAGLGVIALGV FT YGFFATLQPDAHFGRVLAAYGGVFVAGSLAWGMALDGFRPDRWDVIGALGCMAGVAVIM FT YAPRGH" FT CDS complement(192442..192801) FT /transl_table=11 FT /locus_tag="Rv2640c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY ARSR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv2640c, (MTCY441.10c), len: 119 aa. Possible FT transcriptional regulator, arsR family, highly similar to FT many e.g. Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (117 FT aa), FASTA scores: opt: 261, E(): 5.6e-10, (47.75% identity FT in 103 aa overlap); Q9X8X8|SCH35.28c PUTATIVE FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (122 FT aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05% identity FT in 116 aa overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY FT TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa), FT FASTA scores: opt: 252, E(): 2.2e-09, (37.05% identity in FT 116 aa overlap); P77295|YGAV_ECOLI|B2667 HYPOTHETICAL FT TRANSCRIPTIONAL REGULATOR from Escherichia coli strain K12 FT (99 aa), FASTA scores: opt: 156, E(): 0.0023, (34.1% FT identity in 88 aa overlap); etc. Also similar to upstream FT ORF P71941|Rv2642|MTCY441.12 PUTATIVE TRANSCRIPTIONAL FT REGULATORY PROTEIN from Mycobacterium tuberculosis (126 FT aa), FASTA scores: opt: 237, E(): 2e-08, (38.55% identity FT in 109 aa overlap). Contains helix-turn-helix motif at aa FT 59-80 (Score 1166, +3.16 SD). BELONGS TO THE ARSR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:P71939" FT /db_xref="HSSP:1SMT" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:P71939" FT /protein_id="CAB02346.1" FT /translation="MPKSLPVIDISAPVCCAPVAAGPMSDGDALAVALRLKALADPARV FT KIMSYLFSSPAGEQVSGQLAAALSLSDGTVSHHLAQLRKAGLVISDRRGMHVFHRVHPE FT ALQALCTVLNPNCCA" FT CDS 192903..193361 FT /transl_table=11 FT /gene="cadI" FT /locus_tag="Rv2641" FT /product="CADMIUM INDUCIBLE PROTEIN CADI" FT /function="UNKNOWN" FT /note="Rv2641, (MTCY441.11), len: 152 aa. cadI, conserved FT hypothetical protein. Gene induced by cadmium (see Hotter FT et al., 2001), highly similar to hypothetical proteins e.g. FT Q9L222|SC1A2.19c from Streptomyces coelicolor (152 aa), FT FASTA scores: opt: 509, E(): 2.3e-27, (55.05% identity in FT 149 aa overlap); P45945|YQCK_BACSU from Bacillus subtilis FT (146 aa), FASTA scores: opt: 295, E(): 5.4e-13, (33.55% FT identity in 146 aa overlap); and Q98CF8|MLL5167 from FT Rhizobium loti (Mesorhizobium loti) (124 aa), FASTA scores: FT opt: 110, E(): 1.3, (31.4% identity in 121 aa overlap). FT Some similarity with FT Q10548|Y887_MYCTU|Rv0887c|MT0910|MTCY31.15c from FT Mycobacterium tuberculosis (152 aa), FASTA scores: opt: FT 108, E(): 2.1, (25.7% identity in 148 aa overlap)." FT /db_xref="InterPro:IPR004360" FT /db_xref="UniProtKB/Swiss-Prot:P0A5N6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02347.1" FT /translation="MSRVQLALNVDDLEAAITFYSRLFNAEPAKRKPGYANFAIADPPL FT KLVLLENPGTGGTLNHLGVEVGSSNTVHAEIARLTEAGLVTEKEIGTTCCFATQDKVWV FT TGPGGERWEVYTVLADSETFGSGPRHNDTSDGEASMCCDGQVAVGASG" FT CDS 193497..193877 FT /transl_table=11 FT /locus_tag="Rv2642" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY ARSR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv2642, (MTCY441.12), len: 126 aa. Possible FT transcriptional regulator, arsR family, highly similar to FT many e.g. Q9X8X8|SCH35.28c PUTATIVE TRANSCRIPTIONAL FT REGULATOR from Streptomyces coelicolor (122 aa), FASTA FT scores: opt: 390, E(): 3.7e-19, (56.55% identity in 122 aa FT overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY FT TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa), FT FASTA scores: opt: 378, E(): 2.3e-18, (59.8% identity in 97 FT aa overlap); Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (117 FT aa), FASTA scores: opt: 359, E(): 4.1e-17, (56.9% identity FT in 116 aa overlap); P52144|ARR2_ECOLI|ARSR from Escherichia FT coli (117 aa), FASTA scores: opt: 202, E(): 1e-06, (39.8% FT identity in 88 aa overlap); etc. Also similar to downstream FT ORF P71939|Rv2640c|MTCY441.10c PUTATIVE TRANSCRIPTIONAL FT REGULATORY PROTEIN from Mycobacterium tuberculosis (119 FT aa), FASTA scores: opt: 237, E(): 5e-09, (38.55% identity FT in 109 aa overlap); and others from Mycobacterium FT tuberculosis e.g. O05840|Rv2358|MTCY27.22c. Contains FT PS00846 Bacterial regulatory proteins, arsR family FT signature. Contains helix-turn-helix motif at aa 58-79 FT (Score 1112, +2.97 SD). BELONGS TO THE ARSR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:P71941" FT /db_xref="HSSP:1SMT" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:P71941" FT /protein_id="CAB02348.1" FT /translation="MSNLHPLPEVASCVVAPLVREPLNPPAAAEMAARFKALADPVRLQ FT LLSSVASRAGGEACVCDISAGVEVSQPTISHHLKVLRDAGLLTSRRRASWVYYAVVPEA FT LTVLSNLLSVHADAAPALGAPA" FT misc_feature 193671..193727 FT /note="PS00846 Bacterial regulatory proteins, arsR family FT signature" FT CDS 193874..195370 FT /transl_table=11 FT /gene="arsC" FT /locus_tag="Rv2643" FT /product="PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ARSC" FT /function="INVOLVED IN TRANSPORT OF ARSENIC COMPOUNDS FT ACROSS THE MEMBRANE (EXPORT): ARSENIC RESISTANCE BY AN FT EXPORT MECHANISM. RESPONSIBLE FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2643, (MTCY441.13), len: 498 aa. Probable arsC, FT arsenical resistance transport integral membrane protein, FT highly similar or similar to others e.g. Q9L1X4|SC3D9.05 FT POSSIBLE ARSENIC RESISTANCE MEMBRANE TRANSPORT PROTEIN from FT Streptomyces coelicolor (368 aa), FASTA scores: opt: 1729, FT E(): 2.2e-96, (74.3% identity in 358 aa overlap); FT Q9X8Y0|SCH35.26 PUTATIVE HEAVY METAL RESISTANCE MEMBRANE FT PROTEIN from Streptomyces coelicolor (369 aa), FASTA FT scores: opt: 1729, E(): 2.2e-96, (73.8% identity in 359 aa FT overlap); Q06598|ACR3_YEAST|ACR3|YPR201W|P9677.2 FT ARSENICAL-RESISTANCE PROTEIN from Saccharomyces cerevisiae FT (Baker's yeast) (404 aa), FASTA scores: opt: 591, E(): FT 4e-28, (36.6% identity in 380 aa overlap); etc. BELONGS TO FT THE ACR3 FAMILY." FT /db_xref="GOA:P71942" FT /db_xref="HSSP:1JL3" FT /db_xref="InterPro:IPR017867" FT /db_xref="UniProtKB/TrEMBL:P71942" FT /protein_id="CAB02349.1" FT /translation="MTETVTRTAAPAVVGKLSTLDRFLPVWIGSAMAAGLLLGRWIPGL FT HTALEGVQLDGISLPIALGLLIMMYPVLAKVRYDRLDTVTGDRKLLLSSLLLNWVLGPA FT LMFALAWLLLADLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIFQVA FT MFAALGWFYLSVLPGWLGLEQTTIATSPWQIAKSVLIFLGIPLLAGYLSRRIGEKTKGR FT NWYESRFLPKVGPWALYGLLFTIVILFALQGDQITGRPLDVARIALPLLAYFAIMWVGG FT YLLGAALRLGYRRTTTLAFTAASNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLV FT GLVYVSLALRNRLAGPNATHDADKPSVLFVCVHNAGRSQMAAGLLTHLAGDRIEVRSAG FT TEPAGQVNPTAVAAMAEMGIDITANAPTLLTGGQVQSSDVVITMGCGDACPYFPGVSYR FT NWKLPDPAGQPLDVVRMIRDDIADRVQALIAELLATAKTR" FT CDS complement(195497..195814) FT /transl_table=11 FT /locus_tag="Rv2644c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2644c, (MTCY441.14c), len: 105 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P65041" FT /protein_id="CAB02350.1" FT /translation="MSPRRTSGGVVPVDRYRIDEGLIVVLVFAGRDERRRTVCFADKFG FT CVHIGNPDLYRPQTSLPQPLPISSHAISGSRFVETTNRADQQEPIGPNRAELFDQALHA FT G" FT tRNA complement(196461..196532) FT /gene="tRNA-Val(CAC)" FT /product="transfer RNA-Val(CAC)" FT /anticodon=(pos:196498..196500,aa:Val) FT tRNA 196717..196789 FT /gene="tRNA-Gly(GCC)" FT /product="transfer RNA-Gly(GCC)" FT /anticodon=(pos:196750..196752,aa:Gly) FT tRNA 196819..196889 FT /gene="tRNA-Cys(GCA)" FT /product="transfer RNA-Cys(GCA)" FT /anticodon=(pos:196851..196853,aa:Cys) FT tRNA 196906..196977 FT /gene="tRNA-Val(GAC)" FT /product="transfer RNA-Val(GAC)" FT /anticodon=(pos:196938..196940,aa:Val) FT CDS 197087..197518 FT /transl_table=11 FT /locus_tag="Rv2645" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2645, (MTCY441.15), len: 143 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P71944" FT /protein_id="CAB02351.1" FT /translation="MTTTPRQPLFCAHADTNGDPGRCACGQQLADVGPATPPPPWCEPG FT TEPIWEQLTERYGGVTICQWTRYFPAGDPVAADVWIAADDRVVDGRVLRTQPAIHYTEP FT PVLGIGPAAARRLAAELLNAADTLDDGRRQLDDLGEHRR" FT CDS 197515..198513 FT /transl_table=11 FT /locus_tag="Rv2646" FT /product="PROBABLE INTEGRASE" FT /function="SEQUENCE INTEGRATION. INTEGRASE IS NECESSARY FOR FT INTEGRATION OF A PHAGE INTO THE HOST GENOME BY FT SITE-SPECIFIC RECOMBINATION. IN CONJUNCTION WITH FT EXCISIONASE, INTEGRASE IS ALSO NECESSARY FOR EXCISION OF FT THE PROPHAGE FROM THE HOST GENOME." FT /note="Rv2646, (MTCY441.16), len: 332 aa. Probable FT integrase, similar to others e.g. P06723|VINT_BP186|INT FT INTEGRASE from Bacteriophage 186 (336 aa)s FASTA scores: FT opt: 198, E(): 6.3e-05, (30.45% identity in 138 aa FT overlap). COULD BE BELONG TO THE 'PHAGE' INTEGRASE FAMILY." FT /db_xref="GOA:P71945" FT /db_xref="InterPro:IPR013762" FT /db_xref="UniProtKB/TrEMBL:P71945" FT /protein_id="CAB02354.1" FT /translation="MNTATRVRLARKRADRLNLKLIKNGHHFRLRDADEITLAVGHLGV FT VEAFLAAAKSQNKPPGPPPSLHAPPSWRRDIDDYLLNLNAAGQRPATIRLRKTVLCAAA FT HGLGRPPADVTAEHLLDWLGKQQHLSPEGRKTYRSTLRGFFVWAYEMDRVRDYVADSLP FT KVRCPKQPPRPAGDDVWQAALAKADRRIELMIRLAGEAGLRRAEAAQAHTGDLMDGGLL FT LVHGKGGKRRIVPISDYLAALIRDTPHGYLFPNGTGGHLTAEHVGKLVSRALPGDATMH FT TLRHRYATRAYRGSHNLRAVQQLLGHASIVTTERYTALCDDEVRAAAAAAW" FT CDS 198623..198991 FT /transl_table=11 FT /locus_tag="Rv2647" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2647, (MTCY441.17), len: 122 aa (questionable FT ORF). Hypothetical protein, probably corresponds to FT conserved DNA sequence also found in MTCY336.29c and FT Rv1574|MTCY336.30c|O06616 HYPOTHETICAL 11.4 KDA PROTEIN FT from Mycobacterium tuberculosis (103 aa), FASTA scores: FT opt: 170, E(): 0.0002, (69.05% identity in 42 aa overlap). FT Shows weak similarity with Q9EUM1|RESB RESOLVASE PROTEIN FT HOMOLOG from Corynebacterium glutamicum (Brevibacterium FT flavum) (343 aa), FASTA scores: opt: 112, E(): 2.9, (31.05% FT identity in 87 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P71946" FT /protein_id="CAB02355.1" FT /translation="MHVCHTIADVVDRAKAERSENTLRKDFTPSELLAAGRRIAELERP FT KAKQRQREGGDHGRQARYSGLGSMEPKPESERDAHKADTAISEALGISRGHYQRLKRID FT NATRSEAGYRDGLNGWSG" FT repeat_region 199070..199072 FT /note="3 bp direct repeat: TCG at 5'-end of IS6110" FT repeat_region 199073..199100 FT /note="28 bp inverted repeat: TGAACCGCCCCGGCATGTCCGGAGACTC FT at the left end of IS6110" FT repeat_region 199073..200427 FT /mobile_element="insertion sequence:IS6110-10" FT /note="IS6110-10, len: 1355 bp. Insertion sequence IS6110." FT CDS 199124..199450 FT /transl_table=11 FT /locus_tag="Rv2648" FT /product="PROBABLE TRANSPOSASE FOR INSERTION SEQUENCE FT ELEMENT IS6110" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2648, (MTCY441.17A), len: 108 aa. Probable FT transposase for IS6110." FT /db_xref="GOA:P0C5G9" FT /db_xref="InterPro:IPR002514" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9" FT /protein_id="CAB02366.1" FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD FT RPAR" FT CDS <199399..200385 FT /transl_table=11 FT /locus_tag="Rv2649" FT /product="PROBABLE TRANSPOSASE FOR INSERTION SEQUENCE FT ELEMENT IS6110" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2649, (MTCY441.18), len: 328 aa. Probable FT transposase for IS6110." FT /db_xref="GOA:P0C5G8" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8" FT /protein_id="CAB02367.1" FT /translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICTQ FT LTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREG FT IEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADL FT TYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDV FT IHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWR FT SIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG" FT repeat_region complement(200400..200427) FT /note="28 bp inverted repeat, TGAACCGCCCCGGTGAGTCCGGAGACTC, FT at the right end of IS6110." FT repeat_region 200428..200430 FT /note="3 bp direct repeat: TCG at 3'-end of IS6110" FT CDS complement(200759..202198) FT /transl_table=11 FT /locus_tag="Rv2650c" FT /product="POSSIBLE phiRv2 PROPHAGE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2650c, (MTCY441.19), len: 479 aa. Possible phiRv2 FT prophage protein (capsid subunit) (see citation below), FT highly similar to O06614|Rv1576c|MTCY336.28 PROBABLE phiRv1 FT PHAGE PROTEIN from Mycobacterium tuberculosis (473 aa), FT FASTA scores: opt: 2782, E(): 2.8e-159, (89.1% identity in FT 468 aa overlap)." FT /db_xref="InterPro:IPR006444" FT /db_xref="UniProtKB/TrEMBL:P71947" FT /protein_id="CAB02329.1" FT /translation="MTNEQHFADDGDIKQLSLDETRSAAKQLLDSVEGDLTGDVAQRFQ FT ALTRHAEELRAEQRRRGREAEEALRRCRAGELRVVPGAPTGGDDGDAPPGNSLRDIAFR FT TLDVCVRDGLMSSRAAEAAETLCRTGPPQSTSWAQRWLAATGNRDYLGAFVKRVSNPVA FT GHTTWTDREAAAWREAAAVAAEQRAMGLVDTAGGFLIPAALDPAILLSGDGSTNPIRQV FT ARVVQTTSEVWRGVTSEGAEAHWYSEAQEVSDDSPTLAQPAVPSYRGSCWIPFSLEIEG FT DAAGFVAEVGRVLADSVEQLQAAAFVSGSGNGEPTGFVSALTGTADYTVTGAGTEAVVA FT ADVYALQSALPPRFQSNSAFAANLSTINVLRQAETANGALKFPSLHASPPMLAGKHIWE FT VSNMDTVDAAVTATNYPLVLGDWKQFIITDRVGSTVELVPHVFGGNRRPTGQRGFFCWF FT RVGSDVLVDNAFRVLKVQTTA" FT CDS complement(202206..202739) FT /transl_table=11 FT /locus_tag="Rv2651c" FT /product="POSSIBLE phiRv2 PROPHAGE PROTEASE" FT /function="UNKNOWN; POSSIBLY HYDROLYZES PEPTIDES AND/OR FT PROTEINS." FT /EC_number="3.4.-.-" FT /note="Rv2651c, (MTCY441.20c), len: 177 aa. Possible FT protease protein (EC 3.4.-.-), phiRv2 phage protein FT (prohead protease) (see citation below), showing some FT similarity with several proteases e.g. Q9A4P4|CC2786 FT PUTATIVE PROTEASE from Caulobacter crescentus (138 aa), FT FASTA scores: opt: 206, E(): 2e-06, (36.35% identity in 132 FT aa overlap); Q9RNH0 PUTATIVE PROHEAD PROTEASE from FT Rhodobacter capsulatus (Rhodopseudomonas capsulata) (184 FT aa), FASTA scores: opt: 196, E(): 1.1e-05, (35.05% identity FT in 137 aa overlap); BAB35014|ECS1591 PUTATIVE PROHEAD FT PROTEASE from Escherichia coli strain O157:H7 (185 aa), FT FASTA scores: opt: 187, E(): 4.1e-05, (32.9% identity in FT 158 aa overlap); etc. And highly similar to FT O06613|Rv1577c|MTCY336.27 Probable phiRV1 phage protein FT from Mycobacterium tuberculosis (170 aa), FASTA scores: FT opt: 987, E(): 2.3e-56, (89.35% identity in 169 aa FT overlap)." FT /db_xref="GOA:P71948" FT /db_xref="InterPro:IPR006433" FT /db_xref="UniProtKB/TrEMBL:P71948" FT /protein_id="CAB02356.1" FT /translation="MSSILFRTAELRPGEGRTVYGVIVPYGEVTTVRDLDGEFREMFAP FT GAFRRSIAERGHKVKLLVSHDARTRYPVGRAVELREEPHGLFGAFELANTPDGDEALAN FT VKAGVVDAFSVGFRPIRDRREGDVIVRVEAALLEVSLTGVPAYLGAQIAGVRAESLAVV FT SRSLAEARLALMDW" FT CDS complement(202892..203518) FT /transl_table=11 FT /locus_tag="Rv2652c" FT /product="PROBABLE phiRv2 PROPHAGE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2652c, (MTCY441.21c), len: 208 aa. Probable phiRv2 FT phage protein (terminase) (see citation below), showing FT some similarity with AAK79859|Q97HW1|CAC1896 PHAGE FT TERMINASE-LIKE PROTEIN (SMALL SUBUNIT) from Clostridium FT acetobutylicum (151 aa), FASTA scores: opt: 155, E(): FT 0.012, (24.7% identity in 158 aa overlap); and Q9B019 FT HYPOTHETICAL 17.8 KDA PROTEIN from Bacteriophage GMSE-1 FT (159 aa), FASTA scores: opt: 141, E(): 0.087, (27.65% FT identity in 159 aa overlap). Also highly similar to FT O06612|Rv1578c|MTCY336.26 Probable phiRV1 phage protein FT from Mycobacterium tuberculosis (156 aa), FASTA scores: FT opt: 448, E(): 1.2e-20, (48.1% identity in 156 aa overlap). FT Equivalent to AAK47043 from Mycobacterium tuberculosis FT strain CDC1551 but longer 45 aa." FT /db_xref="InterPro:IPR006448" FT /db_xref="UniProtKB/TrEMBL:P71949" FT /protein_id="CAB02357.1" FT /translation="MPSPATARPDTATVGERVRAQVLWGVFWHHGIRDPKPGKRRVVLK FT MGRRGPAPAPAQLKLLGGRSPGRDSGGRRVTPPAAFERVAPECPDWLPPGAKDMWGRVV FT PELAALNLLKESDLGVLTSFCVAWDQLMQAVTAYREQGFIATNARSRRVTVHPAVAAAR FT AATRDVLVLARELGCTPSAEANLAAVLAAAGDPDDDEFNPFAPDR" FT CDS complement(203550..203873) FT /transl_table=11 FT /locus_tag="Rv2653c" FT /product="POSSIBLE phiRv2 PROPHAGE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2653c, (MTCY441.22c), len: 107 aa. Hypothetical FT unknown protein, possibly phiRv2 phage protein (see FT citation below)." FT /db_xref="UniProtKB/TrEMBL:P71950" FT /protein_id="CAB02358.1" FT /translation="MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQ FT RDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLDDEQRRLEAGMKLGWHPYHFPDEPD FT SKQ" FT CDS complement(203953..204198) FT /transl_table=11 FT /locus_tag="Rv2654c" FT /product="POSSIBLE phiRv2 PROPHAGE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2654c, (MTCY441.23c), len: 81 aa. Hypothetical FT ala-rich protein, possibly phiRv2 phage protein (see FT citation below), similar to C-terminus of Q9HNI3|VNG2091H FT HYPOTHETICAL PROTEIN from Halobacterium sp. strain NRC-1 FT (212 aa), FASTA scores: opt: 122, E(): 0.46, (43.05% FT identity in 79 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P71951" FT /protein_id="CAB02330.1" FT /translation="MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVE FT LARALVRAVAESHGVAAVLFAATAAAAAAVDRGDPP" FT CDS complement(204195..205622) FT /transl_table=11 FT /locus_tag="Rv2655c" FT /product="POSSIBLE phiRv2 PROPHAGE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2655c, (MTCY441.24c), len: 475 aa. Hypothetical FT protein, possibly phiRv2 phage protein (putative FT primase-like protein) (see citation below). C-terminus FT similar to P22875|YXIS_SACER HYPOTHETICAL 28.9 KDA PROTEIN FT (PROBABLY DOES NOT PLAY A DIRECT ROLE IN PLASMID FT INTEGRATION OR EXCISION) from Saccharopolyspora erythraea FT (Streptomyces erythraeus) plasmid pSE211 (263 aa), FASTA FT scores: opt: 389, E(): 2.7e-15, (33.45% identity in 269 aa FT overlap). Weak similarity in N-terminus to FT O06608|MTCY336.22|Rv1582c Probable phiRV1 phage protein FT from Mycobacterium tuberculosis (471 aa), FASTA scores: FT opt: 133, E(): 2.5, (36.0% identity in 75 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P71952" FT /protein_id="CAB02331.1" FT /translation="MADIPYGRDYPDPIWCDEDGQPMPPVGAELLDDIRAFLRRFVVYP FT SDHELIAHTLWIAHCWFMEAWDSTPRIAFLSPEPGSGKSRALEVTEPLVPRPVHAINCT FT PAYLFRRVADPVGRPTVLYDECDTLFGPKAKEHEEIRGVINAGHRKGAVAGRCVIRGKI FT VETEELPAYCAVALAGLDDLPDTIMSRSIVVRMRRRAPTEPVEPWRPRVNGPEAEKLHD FT RLANWAAAINPLESGWPAMPDGVTDRRADVWESLVAVADTAGGHWPKTARATAETDATA FT NRGAKPSIGVLLLRDIRRVFSDRDRMRTSDILTGLNRMEEGPWGSIRRGDPLDARGLAT FT RLGRYGIGPKFQHSGGEPPYKGYSRTQFEDAWSRYLSADDETPEERDLSVSAVSAVSPP FT VGDPGDATGATDATDLPEAGDLPYEPPAPNGHPNGDAPLCSGPGCPNKLLSTEAKAAGK FT CRPCRGRAAASARDGAR" FT CDS complement(205624..206016) FT /transl_table=11 FT /locus_tag="Rv2656c" FT /product="POSSIBLE phiRv2 PROPHAGE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2656c, (MTCY441.25c), len: 130 aa. Probable phiRv2 FT phage protein (see Hatfull 2000), highly similar to FT O06607|YF83_MYCTU|Rv1583c|MT3573.2|MTCY336.21 Probable FT phiRV1 phage protein from Mycobacterium tuberculosis (132 FT aa), FASTA scores: opt: 734, E(): 2.5e-39, (81.5% identity FT in 131 aa overlap); and some similarity with Q982T4|MLL8506 FT HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium FT loti) (204 aa), FASTA scores: opt: 104, E(): 9.7, (31.85% FT identity in 113 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P71953" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02332.1" FT /translation="MTAVGGSPPTRRCPATEDRAPATVATPSSTDPTASRAVSWWSVHE FT YVAPTLAAAVEWPMAGTPAWCDLDDTDPVKWAAICDAARHWALRVETCQAASAEASRDV FT SAAADWPAVSREIQRRRDAYIRRVVV" FT CDS complement(206013..206273) FT /transl_table=11 FT /locus_tag="Rv2657c" FT /product="PROBABLE phiRv2 PROPHAGE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2657c, (MTCY441.26c), len: 86 aa. Probable phiRv2 FT phage protein (excisionase) (see citation below), similar FT to O22001|VG36_BPMD2|36|G2 GENE 36 PROTEIN (GP36) from FT Mycobacteriophage D29 (56 aa), FASTA scores: opt: 171, E(): FT 9.6e-06, (48.0% identity in 50 aa overlap); and FT Q05246|VG36_BPML5|36 GENE 36 PROTEIN (GP36) from FT Mycobacteriophage L5 (56 aa), FASTA scores: opt: 169, E(): FT 1.3e-05, (50% identity in 50 aa overlap). Similarity FT suggests alternative start at 21737. Contains possible FT helix-turn-helix motif from aa 33 to 54 (Score 1655, +4.82 FT SD)." FT /db_xref="GOA:P71954" FT /db_xref="InterPro:IPR000551" FT /db_xref="UniProtKB/TrEMBL:P71954" FT /protein_id="CAB02333.1" FT /translation="MCAFPSPSLGWTVSHETERPGMADAPPLSRRYITISEAAEYLAVT FT DRTVRQMIADGRLRGYRSGTRLVRLRRDEVDGAMHPFGGAA" FT CDS complement(206290..206652) FT /transl_table=11 FT /locus_tag="Rv2658c" FT /product="POSSIBLE PROPHAGE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2658c, (MTCY441.27c), len: 120 aa. Hypothetical FT unknown protein, probably phage protein." FT /db_xref="UniProtKB/Swiss-Prot:P71955" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02334.1" FT /translation="MADAVKYVVMCNCDDEPGALIIAWIDDERPAGGHIQMRSNTRFTE FT TQWGRHIEWKLECRACRKYAPISEMTAAAILDGFGAKLHELRTSTIPDADDPSIAEARH FT VIPFSALCLRLSQLGG" FT CDS complement(206655..207782) FT /transl_table=11 FT /locus_tag="Rv2659c" FT /product="PROBABLE phiRv2 PROPHAGE INTEGRASE" FT /function="SEQUENCE INTEGRATION. INTEGRASE IS NECESSARY FOR FT INTEGRATION OF A PHAGE INTO THE HOST GENOME BY FT SITE-SPECIFIC RECOMBINATION. IN CONJUNCTION WITH FT EXCISIONASE, INTEGRASE IS ALSO NECESSARY FOR EXCISION OF FT THE PROPHAGE FROM THE HOST GENOME." FT /note="Rv2659c, (MTCY441.28c), len: 375 aa. Probable FT integrase, phiRv2 phage protein: putative member of the FT phage integrase family of tyrosine recombinases (see FT Hatfull 2000), highly similar to others e.g. FT P22884|VINT_BPML5|33|INT from Mycobacteriophage L5 (371 FT aa), FASTA scores: opt: 836, E(): 1.2e-44, (39.0% identity FT in 372 aa overlap); Q38361|VINT_BPMD2|33|INT from FT Mycobacteriophage D29 (333 aa), FASTA scores: opt: 786, FT E(): 1.4e-41, (40.55% identity in 338 aa overlap); etc. FT SEEMS BELONGS TO THE 'PHAGE' INTEGRASE FAMILY." FT /db_xref="GOA:P71956" FT /db_xref="InterPro:IPR002104" FT /db_xref="UniProtKB/TrEMBL:P71956" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02359.1" FT /translation="MTQTGKRQRRKFGRIRQFNSGRWQASYTGPDGRVYIAPKTFNAKI FT DAEAWLTDRRREIDRQLWSPASGQEDRPGAPFGEYAEGWLKQRGIKDRTRAHYRKLLDN FT HILATFADTDLRDITPAAVRRWYATTAVGTPTMRAHSYSLLRAIMQTALADDLIDSNPC FT RISGASTARRVHKIRPATLDELETITKAMPDPYQAFVLMAAWLAMRYGELTELRRKDID FT LHGEVARVRRAVVRVGEGFKVTTPKSDAGVRDISIPPHLIPAIEDHLHKHVNPGRESLL FT FPSVNDPNRHLAPSALYRMFYKARKAAGRPDLRVHDLRHSGAVLAASTGATLAELMQRL FT GHSTAGAALRYQHAAKGRDREIAALLSKLAENQEM" FT CDS complement(207927..208154) FT /transl_table=11 FT /locus_tag="Rv2660c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2660c, (MTCY441.29c), len: 75 aa (questionable FT orf). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:P71957" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02360.1" FT /translation="MIAGVDQALAATGQASQRAAGASGGVTVGVGVGTEQRNLSVVAPS FT QFTFSSRSPDFVDETAGQSWCAILGLNQFH" FT CDS complement(208151..208540) FT /transl_table=11 FT /locus_tag="Rv2661c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2661c, (MTCY441.30c), len: 129 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P71958" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02335.1" FT /translation="MRARSDAGGQSVKSRTSNRSRSSRRSRVRSSISALVDNPQARPRE FT LPVLCGWPVVRVEPVCEFVPEPVCGQAEVLGEPAAAHRVTSARRSPSTTVCSRSQKASA FT VVISSVSSVARVRRASVSSVDATTA" FT CDS 208446..208718 FT /transl_table=11 FT /locus_tag="Rv2662" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2662, (MTCY441.31), len: 90 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P71959" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02336.1" FT /translation="MDDLTRLRRELLDRFDVRDFTDWPPASLRALIATYDPWIDMTASP FT PQPVSPGGPRLRLVRLTTNPSARAAPIGNGGDSSVCAGEKQCRPP" FT CDS 208817..209050 FT /transl_table=11 FT /locus_tag="Rv2663" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2663, (MTCY441.32), len: 77 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P71960" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02361.1" FT /translation="MEVRASARKHGINDDAMLHAYRNALRYVELEYHGEVQLLVIGPDQ FT TGRLLELVIPADEPPRIIHANVLRPKFYDYLR" FT CDS 209061..209315 FT /transl_table=11 FT /locus_tag="Rv2664" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2664, (MTCY441.33), len: 84 aa. Hypothetical FT protein. Some weak similarity to nearby FT P71964|Rv2667|clpX'|MT2741|MTCY441.36 POSSIBLE FT ATP-DEPENDENT PROTEASE ATP-BINDING SUBUNIT from FT Mycobacterium tuberculosis (252 aa), FASTA scores: opt: FT 134, E(): 0.027, (31.15% identity in 77 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P71961" FT /protein_id="CAB02362.1" FT /translation="MKHKTDIDEWLDTIEPNPADAHDASHLRRIIAAKEAVQTAESELR FT AAVNAARAAGDTWAAIGVALGITRQAAFQRFGPHSTASP" FT CDS 209663..209944 FT /transl_table=11 FT /locus_tag="Rv2665" FT /product="HYPOTHETICAL ARGININE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2665, (MTCY441.34), len: 93 aa. Hypothetical FT arg-rich protein, showing some similarity to N-terminus of FT P71640|Rv2811|MTCY16B7.32c HYPOTHETICAL 21.1 KDA PROTEIN FT from Mycobacterium tuberculosis (202 aa), FASTA scores: FT opt: 157, E(): 0.0011, (37.5% identity in 72 aa overlap); FT and also to part of O35132|CP2B_RAT|CYP27B1|CYP27B FT 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL FT PRECURSOR from Rattus norvegicus (Rat) (501 aa), FASTA FT scores: opt: 106, E(): 5.4, (34.5% identity in 87 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:P71962" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02368.1" FT /translation="MIVVRTAEAAEQALTEGQLVCPRRGCGDTLRRWRYGRRRHVRSLG FT SQVIDVRPQRVRCRRCESTHVLLPAALQPRLGRGGGGQLRPGVWCTGR" FT repeat_region 209910..210818 FT /mobile_element="insertion sequence:IS1081'-4" FT /note="IS1081'-4, len: 909 bp. Defective Insertion sequence FT IS1081 element; truncated at 3'-end." FT repeat_region 209983..209997 FT /note="15 bp Inverted repeat at the left end of FT IS1081:TCGCGTGATCCTTCG, right end copy is missing" FT CDS 210035..210838 FT /transl_table=11 FT /locus_tag="Rv2666" FT /product="PROBABLE TRANSPOSASE FOR INSERTION SEQUENCE FT ELEMENT IS1081 (FRAGMENT)" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1081." FT /note="Rv2666, (MTCY441.35), len: 267 aa. Probable FT transposase (fragment), identical in region of overlap to FT P35882|TRA1_MYCBO|TRA1_MYCTU TRANSPOSASE FOR INSERTION FT SEQUENCE ELEMENT IS1081 from Mycobacterium tuberculosis or FT bovis (415 aa). Last 4 codons not part of gene. Contains FT PS01007 Transposases, Mutator family, signature." FT /db_xref="GOA:P71963" FT /db_xref="InterPro:IPR001207" FT /db_xref="UniProtKB/TrEMBL:P71963" FT /protein_id="CAB02337.1" FT /translation="MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALC FT GAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALT FT SVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTF FT LAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVAR FT GLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANHGRHNA" FT misc_feature 210731..210805 FT /note="PS01007 Transposases, Mutator family, signature" FT CDS 210860..211618 FT /transl_table=11 FT /gene="clpC2" FT /locus_tag="Rv2667" FT /standard_name="clpX'" FT /product="POSSIBLE ATP-DEPENDENT PROTEASE ATP-BINDING FT SUBUNIT CLPC2" FT /function="UNKNOWN; POSSIBLY HYDROLYZES PEPTIDES AND/OR FT PROTEINS IN PRESENCE OF ATP." FT /EC_number="3.4.-.-" FT /note="Rv2667, (MTCY441.36), len: 252 aa. Possible clpC2, FT ATP-dependent protease atp-binding subunit (EC 3.4.-.-), FT highly similar to Q9X8L2|SCE9.40 HYPOTHETICAL 27.3 KDA FT PROTEIN from Streptomyces coelicolor (258 aa), FASTA FT scores: opt: 877, E(): 2.2e-46, (57.25% identity in 255 aa FT overlap). The second half of the protein is highly similar FT to N-terminal of several CLP-FAMILY proteins e.g. FT P24428|CLPC_MYCLE|ML0235 PROBABLE ATP-DEPENDENT CLP FT PROTEASE ATP-BINDING SUBUNIT from Mycobacterium leprae (848 FT aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6% identity FT in 158 aa overlap); FT O06286|CLPC_MYCTU|Rv3596c|MT3703|MTCY07H7B.26 PROBABLE FT ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from FT Mycobacterium tuberculosis (848 aa), FASTA scores: opt: FT 307, E(): 3.2e-11, (38.6% identity in 158 aa overlap); FT Q9S6T8|SCE94.24c PUTATIVE CLP-FAMILY ATP-BINDING PROTEASE FT from Streptomyces coelicolor (841 aa), FASTA scores: opt: FT 303, E(): 5.6e-11, (38.8% identity in 152 aa overlap); etc. FT Some weak similarity to nearby P71961|MTCY441.33|Rv2664 FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (83 FT aa). Contain Pfam match to entry PF02861 Clp amino terminal FT domain. BELONGS TO THE CLPA/CLPB FAMILY. CLPC SUBFAMILY. FT Note that previously known as clpX'" FT /db_xref="GOA:P0A524" FT /db_xref="InterPro:IPR004176" FT /db_xref="UniProtKB/Swiss-Prot:P0A524" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55509.1" FT /translation="MPEPTPTAYPVRLDELINAIKRVHSDVLDQLSDAVLAAEHLGEIA FT DHLIGHFVDQARRSGASWSDIGKSMGVTKQAAQKRFVPRAEATTLDSNQGFRRFTPRAR FT NAVVAAQNAAHGAASSEITPDHLLLGVLTDPAALATALLQQQEIDIATLRTAVTLPPAV FT TEPPQPIPFSGPARKVLELTFREALRLGHNYIGTEHLLLALLELEDGDGPLHRSGVDKS FT RAEADLITTLASLTGANAAGATDAGATDAG" FT CDS 211697..212218 FT /transl_table=11 FT /locus_tag="Rv2668" FT /product="POSSIBLE EXPORTED ALANINE AND VALINE RICH FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv2668, (MTCY441.37), len: 173 aa. Hypothetical FT ala-, val-rich protein, possibly exported. Equivalent to FT AAK47057 from Mycobacterium tuberculosis strain CDC1551 FT (208 aa) but N-terminal part shorter 35 aa and with few FT differences. Has potential signal peptide sequence." FT /db_xref="UniProtKB/TrEMBL:P71965" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02339.1" FT /translation="MRHWLIVLATLLVAAAGVAAANDVPRAWAGDAPIGHIGDTLRVDT FT GTYVADVTVSSVVPVDPPPGFGYTRSGVPVKSFPDSSVTRADVTVRAVRVPNSFILATN FT FSFTGVTPFADAYKPRPCDASDWLDAALGNAPQGSIVRGGVYWDAYRDPVSVVVLLDEK FT TGQHLAQWNL" FT CDS 212247..212717 FT /transl_table=11 FT /locus_tag="Rv2669" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2669, (MTCY441.38), len: 156 aa. Conserved FT hypothetical protein, showing some similarity to various FT proteins e.g. Q9A6M0|CC2073 ACETYLTRANSFERASE (GNAT FAMILY) FT from Caulobacter crescentus (178 aa), FASTA scores: opt: FT 242, E(): 1.2e-09, (30.9% identity in 165 aa overlap); FT Q99RQ8|SA2159 hypothetical protein similar to transcription FT repressor of sporulation, septation and degradation paiA FT from Staphylococcus aureus subsp. aureus N315 (171 aa), FT FASTA scores: opt: 214, E(): 9.8e-08, (27.5% identity in FT 160 aa overlap); BAB58531|SAV2369 HYPOTHETICAL 20.1 KDA FT PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (171 FT aa), FASTA scores: opt: 214, E(): 9.8e-08, (27.5% identity FT in 160 aa overlap); P21340|PAIA_BACSU|O32112 PROTEASE FT SYNTHASE AND SPORULATION from Bacillus subtilis (171 aa), FT FASTA scores: opt: 209, E(): 2.1e-07, (22.85% identity in FT 162 aa overlap); etc." FT /db_xref="GOA:P63425" FT /db_xref="InterPro:IPR000182" FT /db_xref="UniProtKB/Swiss-Prot:P63425" FT /protein_id="CAB02363.1" FT /translation="MTDADELAAVAARTFPLACPPAVAPEHIASFVDANLSSARFAEYL FT TDPRRAILTARHDGRIVGYAMLIRGDDRDVELSKLYLLPGYHGTGAAAALMHKVLATAA FT DWGALRVWLGVNQKNQRAQRFYAKTGFKINGTRTFRLGAHHENDYVMVRELV" FT CDS complement(212695..213804) FT /transl_table=11 FT /locus_tag="Rv2670c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2670c, (MTCY441.39c), len: 369 aa. Conserved FT hypothetical protein, equivalent, but longer 164 aa, to FT O05683|MLC1351.22c HYPOTHETICAL 17.3 KDA PROTEIN from FT Mycobacterium leprae (160 aa), FASTA scores: opt: 847, E(): FT 1.2e-45, (82.4% identity in 159 aa overlap). And highly FT similar to Q9X824|SC9B1.04c PUTATIVE ATP/GTP-BINDING FT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (350 FT aa), FASTA scores: opt: 1169, E(): 2e-65, (56.85% identity FT in 343 aa overlap); and Q9RWB0|DR0759 CONSERVED FT HYPOTHETICAL PROTEIN from Deinococcus radiodurans (351 aa), FT FASTA scores: opt: 859, E(): 4e-46, (45.9% identity in 331 FT aa overlap). Also some similarity with other proteins e.g. FT P46442|YHCM_ECOLI|AAG58360|BAB37528 HYPOTHETICAL PROTEIN FT from Escherichia coli strains K12 and O157:H7 (375 aa), FT FASTA scores: opt: 237, E(): 2.1e-07, (28.0% identity in FT 325 aa overlap); Q9JRK2|NMA1520|NMB1306 PUTATIVE FT NUCLEOTIDE-BINDING PROTEIN from Neisseria meningitidis FT (serogroup A and B) (383 aa), FASTA scores: opt: 221, E(): FT 2.1e-06, (27.8% identity in 356 aa overlap); Q9HVX7|PA4438 FT HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (364 aa), FT FASTA scores: opt: 211, E(): 8.5e-06, (28.9% identity in FT 353 aa overlap); etc. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /db_xref="GOA:P71967" FT /db_xref="InterPro:IPR005654" FT /db_xref="UniProtKB/TrEMBL:P71967" FT /protein_id="CAB02324.1" FT /translation="MTLIAARRYSATMHGSASEACGSVDHLVDRHPTVSPVRLIAQLRP FT PPTFAEVSFATYRPDPVEPTQAAAVVACQDFCRQAVERRAGRKKWFGKRDVLPGVGLYL FT DGGFGVGKTHLLASAYYQLPGTGPDAPTCPKAFATFGELTQLAGVFGFADCIDLLANYT FT ALCIDEFELDDPGNTTLISRLLSALVERGVSVAATSNTLPEQLGEGRFAAQDFLREINT FT LASIFTTVRIEGPDYRHRDLPPAPAPLSDEEVAARAARVEGATLDDFDALCAHLATMHP FT SRYLTLIEGVTAVFLTGVHGIDDQNVALRLVALVDRLYDAGIPVVASGAKLDTIFSEEM FT LAGGYRKKYLRATSRLLALTAGVIQAREP" FT misc_feature complement(213466..213489) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 213803..214579 FT /transl_table=11 FT /gene="ribD" FT /locus_tag="Rv2671" FT /standard_name="ribG" FT /product="POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN FT BIOSYNTHESIS PROTEIN RIBD: FT DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE FT (RIBOFLAVIN-SPECIFIC DEAMINASE) + FT 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP FT REDUCTASE)" FT /function="INVOLVED IN RIBOFLAVIN BIOSYNTHESIS (AT THE FT SECOND AND THIRD STEPS). CONVERTS FT 2,5-DIAMINO-6-(RIBOSYLAMINO)-4(3H)-PYRIMIDINONE FT 5'-PHOSPHATE INTO FT 5-AMINO-6-(RIBOSYLAMINO)-2,4(1H,3H)-PYRIMIDINEDIONE FT 5'-PHOSPHATE [CATALYTIC ACTIVITY 1: FT 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE + FT H(2)O = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NH(3)] FT [CATALYTIC ACTIVITY 2: FT 5-AMINO-6-(5-PHOSPHORIBITYLAMINO)URACIL + NADP(+) = FT 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NADPH]." FT /EC_number="3.5.4.26" FT /EC_number="1.1.1.193" FT /note="Rv2671, (MTCY441.40), len: 258 aa. Possible ribD FT (alternate gene name: ribG), bifunctional riboflavin FT biosynthesis protein incuding FT diaminohydroxyphosphoribosylaminopyrimidine deaminase and FT 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC FT 3.5.4.26 and 1.1.1.193), highly similar to FT O05684|MLC1351.23|ML1340 POSSIBLE REDUCTASE from FT Mycobacterium leprae (268 aa), FASTA sco |