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EBI DbfetchID BX842579; SV 1; linear; genomic DNA; STD; PRO; 348247 BP. XX AC BX842579; AL021246; AL021925; AL021957; Z70283; Z70692; Z77163; Z79702; AC Z81368; Z81371; Z81451; Z83860; Z95208; Z95388; XX DT 21-NOV-2003 (Rel. 77, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 6) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 8/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-348247 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF00010; RNaseP_bact_a. DR UniProtKB/Swiss-Prot; Q50659; Y2306_MYCTU. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..348247 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT CDS complement(209..2248) FT /transl_table=11 FT /gene="pbpB" FT /locus_tag="Rv2163c" FT /product="Probable penicillin-binding membrane protein FT pbpB" FT /function="Involved in peptidoglycan biosynthesis." FT /note="Rv2163c, (MTCY270.05), len: 679 aa. Probable pbpB, FT penicillin-binding membrane protein, similar to many FT bacterial PBP2 proteins e.g. FT P11882|PBP2_NEIME|PENA|NMA2072|NMB0413 penicillin-binding FT protein 2 (pbp-2) from Neisseria meningitidis (serogroups A FT and B) (581 aa), FASTA scores: opt: 665, E(): 1.6e-31, FT (33.2% identity in 591 aa overlap); etc. Also similar to FT Rv0016c and Rv2864c from Mycobacterium tuberculosis FT (2.8e-10). Contains PS00017 possible ATP/GTP-binding site FT motif A (P-loop) near C-terminus. FASTA best: PBP2_NEIME FT P11882 penicillin-binding protein 2 (pbp-2). (581 aa) opt: FT 665, E(): 1.6e-31; (33 .2% identity in 591 aa overlap)" FT /db_xref="GOA:O06214" FT /db_xref="HSSP:1QME" FT /db_xref="InterPro:IPR001460" FT /db_xref="UniProtKB/TrEMBL:O06214" FT /protein_id="CAB08664.1" FT /translation="MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQA FT QEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVAAT FT QLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKRIR FT RQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDP FT AVASAICAKYPEVGAERQDLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDG FT SVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSGAHNVSA FT VVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEH FT GLSSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERY FT YDMLRKFGLGQRTGVGLPGESAGLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAI FT ANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVRQMLRAVVQRDPMGYQQ FT GTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNP FT ARNSDGAPGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT" FT misc_feature complement(470..493) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(2245..3399) FT /transl_table=11 FT /locus_tag="Rv2164c" FT /product="PROBABLE CONSERVED PROLINE RICH MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2164c, (MTCY270.04), len: 384 aa. Probable pro- FT rich conserved membrane protein, equivalent to FT ML0907|AL022602 putative conserved membrane protein from FT Mycobacterium leprae (377 aa) (AL022602), FASTA scores: FT opt: 1495, E(): 1.7e-56, (62.217% identity in 397 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:O06213" FT /protein_id="CAB08663.1" FT /translation="MRAKREAPKSRSSDRRRRADSPAAATRRTTTNSAPSRRIRSRAGK FT TSAPGRQARVSRPGPQTSPMLSPFDRPAPAKNTSQAKARAKARKAKAPKLVRPTPMERL FT AARLTSIDLRPRTLANKVPFVVLVIGSLGVGLGLTLWLSTDAAERSYQLSNARERTRML FT QQHKEALERDVREAASAPALAEAARRQGMIPTRDTAHLVQDPDGNWVVVGTPKPADGVP FT PPPLNTKLPEDPPPPPKPAAVPLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGTATLGG FT ATHLPTQAGPQLPGPVPIPGAPGPMPAPPLGAVPSPAPAENPVPLQVGAAPPAGLPGPA FT PVAATPGLSGGSQPMVAPPAPVPANGEQFGPVTAPVPTAPGAPR" FT CDS complement(3396..4586) FT /transl_table=11 FT /locus_tag="Rv2165c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2165c, (MTCY270.03), len: 396 aa. Conserved FT hypothetical protein; shows strong similarity to several FT hypothetical bacterial proteins but has extra 80 aa FT residues at N-terminus FASTA best: YLXA_BACSU Q07876 FT hypothetical 35.3 kDa protein in ftsl (311 aa) opt: 781, FT E(): 0; (45.6% identity in 296 aa overlap), BELONGS TO THE FT YABC (E.COLI), YLXA (B.SUBTILIS) FAMILY" FT /db_xref="GOA:P65429" FT /db_xref="HSSP:1M6Y" FT /db_xref="InterPro:IPR002903" FT /db_xref="UniProtKB/Swiss-Prot:P65429" FT /protein_id="CAB08662.1" FT /translation="MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTAC FT QTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHA FT ERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVG FT SVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADIL FT RRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALR FT IAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVE FT LPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS" FT CDS complement(4588..5019) FT /transl_table=11 FT /locus_tag="Rv2166c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2166c, (MTCY270.02), len: 143 aa. Conserved FT hypothetical protein; shows strong similarity to several FT hypothetical bacterial proteins such as YLLB_BACSU P55343. FT Is equivalent to Mycobacterium leprae hypothetical protein FT ML0905 (143 aa, 92% identity) MLCB268.11c FT >sp|O69561|YL66_MYCLE HYPOTHETICAL 16.1 KDA PROTEIN ML0905 FT >gi|3080482|emb|CAA18677.1|(AL022602) FT >gi|13092975|emb|CAC31286.1|(AL583920). FASTA scores: FT ML0905|ML0905 conserved hypothetical protein (143 aa) opt: FT 873, E(): 3.1e-52; 92.254% identity in 142 aa overlap; FT YLLB_BACSU P55343 hypothetical 16.6 kDa protein (143 aa) FT opt: 340, E(): 3.6e-17; (35.0% identity in 143 aa overlap). FT BELONGS TO THE YABB (E.COLI), YLLB (B.SUBTILIS), MG221 ( FT M.GENITALIUM) FAMILY" FT /db_xref="InterPro:IPR003444" FT /db_xref="UniProtKB/Swiss-Prot:P65436" FT /protein_id="CAB08661.1" FT /translation="MFLGTYTPKLDDKGRLTLPAKFRDALAGGLMVTKSQDHSLAVYPR FT AAFEQLARRASKAPRSNPEARAFLRNLAAGTDEQHPDSQGRITLSADHRRYASLSKDCV FT VIGAVDYLEIWDAQAWQNYQQIHEENFSAASDEALGDIF" FT repeat_region complement(5278..5305) FT /note="28 bp Inverted repeat at the left end of IS6110; FT GAGTCTCCGGACTCACCGGGGCGGTTCA" FT repeat_region complement(5278..6632) FT /mobile_element="insertion sequence:IS6110-6" FT /note="IS6110-6, len: 1355 bp. Insertion sequence IS6110." FT CDS complement(5320..>6360) FT /transl_table=11 FT /locus_tag="Rv2167c" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2167c, (MTCY270.01), len: 346 aa. Probable IS6110 FT transposase. FASTA best: TRA9_MYCTU P19774 putative FT transposase for insertion sequence (identical)" FT /db_xref="GOA:P0C5G8" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8" FT /protein_id="CAA17494.1" FT /translation="AEALAAGQRRIAKGERDFKDRVGFLRGRARPASTLITRFIADHQG FT HREGPDGLRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAA FT NYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADL FT VQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAI FT EQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAE FT TINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQR FT QRPAAG" FT CDS complement(6255..6581) FT /transl_table=11 FT /locus_tag="Rv2168c" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2168c, (MTV021.01c), len: 108 aa. Probable IS6110 FT transposase. FASTA scores: O08155|O08155 HYPOTHETICAL 12.0 FT kDa PROTEIN (108 aa) opt: 697, E(): 0, (100.0% identity in FT 108 aa overlap). TBparse score is 0.928." FT /db_xref="GOA:P0C5G9" FT /db_xref="InterPro:IPR002514" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9" FT /protein_id="CAA17472.1" FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD FT RPAR" FT repeat_region complement(6605..6632) FT /note="28 bp Inverted repeat at the right end of IS6110, FT TGAACCGCCCCGGCATGTCCGGAGACTC" FT CDS complement(6726..7130) FT /transl_table=11 FT /locus_tag="Rv2169c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2169c, (MTV021.02c), len: 134 aa. Probable FT conserved transmembrane protein, with orthologs in M. FT leprae, ML0904 probable membrane protein (134 aa), and FT Streptomyces coelicolor. FASTA scores with ML0904, opt: FT 767, E(): 5.1e-43; 86.567% identity in 134 aa overlap. FT emb|CAA18678.1| (AL022602) >gi|13092974|emb|CAC31285.1| FT (AL583920). TBparse score is 0.934" FT /db_xref="GOA:O53503" FT /db_xref="UniProtKB/TrEMBL:O53503" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17473.1" FT /translation="MPLSDHEQRMLDQIESALYAEDPKFASSVRGGGFRAPTARRRLQG FT AALFIIGLGMLVSGVAFKETMIGSFPILSVFGFVVMFGGVVYAITGPRLSGRMDRGGSA FT AGASRQRRTKGAGGSFTSRMEDRFRRRFDE" FT CDS 7396..8016 FT /transl_table=11 FT /locus_tag="Rv2170" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2170, (MTV021.03), len: 206 aa. Conserved FT hypothetical protein, equivalent to hypothetical protein FT ML0903 (210 aa) from Mycobacterium leprae. FASTA scores: FT ML0903 conserved hypothetical protein (210 aa) opt: 1045, FT E(): 9.1e-57; 77.143% identity in 210 aa overlap. FT >emb|CAA18679.1| (AL022602) >gi|13092973|emb|CAC31284.1| FT (AL583920). TBparse score is 0.905" FT /db_xref="GOA:O53504" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:O53504" FT /protein_id="CAA17474.1" FT /translation="MAIFLIDLPPSDMERRLGDALTVYVDAMRYPRGTETLRAPMWLEH FT IRRRGWQAVAAVEVTAAEQAEAADTTALPSAAELSNAPMLGVAYGYPGAPGQWWQQQVV FT LGLQRSGFPRLAIARLMTSYFELTELHILPRAQGRGLGEALARRLLAGRDEDNVLLSTP FT ETNGEDNRAWRLYRRLGFTDIIRGYHFAGDPRAFAILGRTLPL" FT CDS 8112..8795 FT /transl_table=11 FT /gene="lppM" FT /locus_tag="Rv2171" FT /product="Probable conserved lipoprotein lppM" FT /function="UNKNOWN" FT /note="Rv2171, (MTV021.04), len: 227 aa. Probable lppM, FT conserved lipoprotein; contains putative signal peptide and FT appropriately positioned PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. Has hydrophobic stretch FT at C-terminus and also contains PS00225 Crystallins beta FT and gamma 'Greek key' motif signature. Unknown but FT equivalent to Mycobacterium leprae lipoprotein ML0902 (239 FT aa). FASTA scores: opt: 1083, E(): 2.4e-56; 75.446% FT identity in 224 aa overlap (5-227:16-239) >emb|CAA18680.1| FT (AL022602) >gi|13092972|emb|CAC31283.1| (AL583920). TBparse FT score is 0.895" FT /db_xref="UniProtKB/TrEMBL:O53505" FT /protein_id="CAA17475.1" FT /translation="MARTRRRGMLAIAMLLMLVPLATGCLRVRASITISPDDLVSGEII FT AAAKPKNSKDTGPALDGDVPFSQKVAVSNYDSDGYVGSQAVFSDLTFAELPQLANMNSD FT AAGVNLSLRRNGNIVILEGRADLTSVSDPDADVELTVAFPAAVTSTNGDRIEPEVVQWK FT LKPGVVSTMSAQARYTDPNTRSFTGAGIWLGIAAFAAAGVVAVLAWIDRDRSPRLTASG FT DPPTS" FT misc_feature 8154..8186 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT misc_feature 8325..8372 FT /note="PS00225 Crystallins beta and gamma 'Greek key' motif FT signature" FT CDS complement(8792..9697) FT /transl_table=11 FT /locus_tag="Rv2172c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2172c, (MTV021.05c), len: 301 aa. Conserved FT hypothetical protein, equivalent to Mycobacterium leprae FT conserved hypothetical protein ML0901 (304 aa). FASTA FT scores: opt: 1656, E(): 7.7e-98; 81.271% identity in 299 aa FT overlap (1-299:1-299) >emb|CAA18681.1| (AL022602) FT >gi|13092971|emb|CAC31282.1| (AL583920) . TBparse score is FT 0.905" FT /db_xref="UniProtKB/TrEMBL:O53506" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17476.1" FT /translation="MTLNTIALELVPPNLEGGKERAIEDARKVVQYSAASGLDGRIRHV FT MMPGMIAEDDDRPIPMQPKLDVLDFWSIIKPELAGVHGLCTQVTAFMDEPSLHRRLVDL FT SDAGMEGIVFVGVPRTMQDGEGSGVAPTDALSLYRQLVANRGVIVIPTRDGEQGRLNFK FT CSRGATYGMTQLLYSDAIVGFLREFARTTEHRPEILLSFGFVPKVETRIGLINWLIQDP FT GNAAVADEQAFVQKLAGSEPARRRRLMVDLYKRVLDGVADLGFPLSIHLEATYGVSAAA FT FETFAEMLAYWSPAEPGKPD" FT CDS 10008..11066 FT /transl_table=11 FT /gene="idsA2" FT /locus_tag="Rv2173" FT /product="PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE FT IDSA2 (GGPPSASE) (GGPP SYNTHETASE) (GERANYLGERANYL FT DIPHOSPHATE SYNTHASE)" FT /function="INVOLVED IN LIPID BIOSYNTHESIS." FT /EC_number="2.5.1.-" FT /note="Rv2173, (MTV021.06), len: 352 aa. Probable idsA2, FT geranylgeranyl pyrophosphate synthase (EC 2.5.1.-), similar FT to many e.g. Q54193 geranylgeranyl pyrophosphate synthase FT from Streptomyces griseus (425 aa). Contains PS00723 and FT PS00444Polyprenyl synthetases signature 1 and 2. FASTA FT scores: sptr|Q54193|Q54193 GERANYLGERANYL PYROPHOSPHATE FT SYNTHASE (425 aa) opt: 744, E(): 0; 39.2% identity in 352 FT aa overlap. TBparse score is 0.900" FT /db_xref="GOA:O53507" FT /db_xref="InterPro:IPR017446" FT /db_xref="UniProtKB/TrEMBL:O53507" FT /protein_id="CAA17477.1" FT /translation="MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRL FT RPLFAYWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQLRYA FT ALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPDAQRRVHRVWADIR FT NEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFE FT HFGADLGVAFQLRDDVLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAK FT LLRTSIGTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGL FT SELAMMAANRSA" FT misc_feature 10248..10292 FT /note="PS00723 Polyprenyl synthetases signature 1" FT misc_feature 10689..10727 FT /note="PS00444 Polyprenyl synthetases signature 2" FT CDS 11070..12620 FT /transl_table=11 FT /locus_tag="Rv2174" FT /product="Possible conserved integral membrane protein" FT /function="UNKNOWN" FT /note="Rv2174, (MTV021.07), len: 516 aa. Possible conserved FT integral membrane protein, similar to some hypothetical FT mycobacterial proteins e.g. Mycobacterium leprae ML0899 FT probable integral-membrane protein (505 aa) and MLCL536_26 FT (593 aa). FASTA scores: ML0899 opt: 2715; 78.884% identity FT in 502 aa overlap and gp|Z99125|MLCL536_26 Mycobacterium FT leprae cosmid L536. (593 aa) opt: 552, E(): 7.1e-30; 31.6% FT identity in 513 aa overlap. Also similar to Rv1459c. FT TBparse score is 0.912" FT /db_xref="InterPro:IPR017822" FT /db_xref="UniProtKB/TrEMBL:O53508" FT /protein_id="CAA17478.1" FT /translation="MTTPSHAPAVDLATAKDAVVQHLSRLFEFTTGPQGGPARLGFAGA FT VLITAGGLGAGSVRQHDPLLESIHMSWLRFGHGLVLSSILLWTGVGVMLLAWLGLGRRV FT LAGEATEFTMRATTVIWLAPLLLSVPVFSRDTYSYLAQGALLRDGLDPYAVGPVGNPNA FT LLDDVSPIWTITTAPYGPAFILVAKFVTVIVGNNVVAGTMLLRLCMLPGLALLVWATPR FT LASHLGTHGPTALWICVLNPLVLIHLMGGVHNEMLMVGLMTAGIALTVQGRNVAGIILI FT TVAIAVKATAGIALPFLVWVWLRHLRERRGYRPVQAFLAAAAISLLIFVAVFAVLSAVA FT GVGLGWLTALAGSVKIINWLTVPTGAANVIHALGRGLFTVDFYTLLRITRLIGIVIIAV FT SLPLLWWRFRRDDRAALTGVAWSMLIVVLFVPAALPWYYSWPLAVAAPLAQARRAIAAI FT AGLSTWVMVIFKPDGSHGMYSWLHFWIATACALTAWYVLYRSPDRRGVQAATPVVNTP" FT CDS complement(12607..13047) FT /transl_table=11 FT /locus_tag="Rv2175c" FT /product="conserved hypothetical regulatory protein" FT /function="UNKNOWN" FT /note="Rv2175c, (MTV021.08c), len: 146 aa. Conserved FT hypothetical protein, possibly involved in regulation. FT Contains possible helix-turn-helix domain at aa 31-52 FT (Score 1042, +2.74 SD). Equivalent to Mycobacterium leprae FT ML0898 putative DNA-binding protein (134 aa). FASTA scores: FT opt: 747; 82.090% identity in 134 aa overlap (AL022602) FT >gi|13092969|emb|CAC31279.1| (AL583920)" FT /db_xref="PDB:2KFS" FT /db_xref="UniProtKB/TrEMBL:O53509" FT /protein_id="CAA17479.1" FT /translation="MPGRAPGSTLARVGSIPAGDDVLDPDEPTYDLPRVAELLGVPVSK FT VAQQLREGHLVAVRRAGGVVIPQVFFTNSGQVVKSLPGLLTILHDGGYRDTEIMRWLFT FT PDPSLTITRDGSRDAVSNARPVDALHAHQAREVVRRAQAMAY" FT CDS 13102..14301 FT /transl_table=11 FT /gene="pknL" FT /locus_tag="Rv2176" FT /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN FT KINASE L PKNL (PROTEIN KINASE L) (STPK L)" FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). MAY BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /EC_number="2.7.1.-" FT /note="Rv2176, (MTV021.09), len: 399 aa. Probable pknL, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-) FT (see citation below), similar to many e.g. MLCB1770_9 (622 FT aa). Lacks C-terminal domain and ends with putative FT transmembrane segment. Contains PS00108 Serine/Threonine FT protein kinases active-site signature. FASTA scores: FT Z70722|MLC B1770_9 Mycobacterium leprae cosmid B1770 (622 FT aa) opt: 732, E(): 5.9e-23; 44.4% identity in 266 aa FT overlap. Also similar to several Mycobacterium tuberculosis FT STPK proteins e.g. Rv0014c|PKNB, Rv0015c|PKNA, Rv1743|PKNE, FT Rv1266c|PKNH etc. Contains Hank's kinase subdomain. BELONGS FT TO THE SER/THR FAMILY OF PROTEIN KINASES.TBparse score is FT 0.921." FT /db_xref="GOA:O53510" FT /db_xref="HSSP:1MRU" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:O53510" FT /protein_id="CAA17480.1" FT /translation="MVEAGTRDPLESALLDSRYLVQAKIASGGTSTVYRGLDVRLDRPV FT ALKVMDSRYAGDEQFLTRFRLEARAVARLNNRALVAVYDQGKDGRHPFLVMELIEGGTL FT RELLIERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKLADFGL FT VRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPFTGDS FT ALSIAYQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLEAIAEE FT LALPEFRVPAPRNSAQHRSAALYRSRITQQGQLGAKPVHHPTRQLTRQPGDCSEPASGS FT EPEHEPITGQFAGIAIEEFIWARQHARRMVLVWVSVVLAITGLVASAAWTIGSNLSGLL FT " FT misc_feature 13513..13551 FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT repeat_region complement(14306..15109) FT /mobile_element="insertion sequence:IS1558-1" FT /note="IS1558-1, len: 804 bp. Insertion sequence IS1558, FT nearly identical to complement of region 24105 24908 in FT EM_BA:MTCY428 Z81451 Mycobacterium tuberculosis cosmid FT Y428." FT CDS complement(14443..15108) FT /transl_table=11 FT /locus_tag="Rv2177c" FT /product="POSSIBLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF AN INSERTION FT ELEMENT, POSSIBLY IS1558." FT /note="Rv2177c, (MTV021.10c), len: 221 aa. Possible IS1558 FT transposase (see citation below), similar to several IS FT element proteins and transposases but nearly identical to FT last 221 residues of MTCY428_23 (333 aa). FASTA scores: FT Z81451|MTCY428_23 Mycobacterium tuberculosis cosmid (333 FT aa) opt: 1491, E() : 0; 98.6% identity in 221 aa overlap. FT TBparse score is 0.904." FT /db_xref="GOA:O53511" FT /db_xref="InterPro:IPR003346" FT /db_xref="UniProtKB/TrEMBL:O53511" FT /protein_id="CAA17481.1" FT /translation="MRSKIPDLQRALEGRFDDHHALMCRLHLAHLDQLDAMIGALDEQI FT EQLMHPFCARRELIASIPGIGVGASATVISEIGADPAAWFPSAEHLASWVRLCPGNHES FT AGKRHHGARRTGNQHLQPVLVECAWAAVRTDGYLREYYRRQVRKFGGFRSPAANKKAII FT AVAHKLIVIIWHVLATGRPYQDLGADYFTTRMDPDKERRRLVAKLEAQGLGVTLEPAA" FT CDS complement(15493..16881) FT /transl_table=11 FT /gene="aroG" FT /locus_tag="Rv2178c" FT /product="Probable 3-deoxy-D-arabino-heptulosonate FT 7-phosphate synthase AroG (DAHP synthetase, FT phenylalanine-repressible)" FT /function="chorismate biosynthesis" FT /EC_number="2.5.1.54" FT /note="Rv2178c, (MTV021.11c), len: 462 aa. Probable aroG, FT 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase FT similar to many, especially those from plants. FASTA FT scores: Y15113|M C3DDAH7P_1Morinda citrifolia mRNA for FT 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (535 FT aa) opt: 1421, E(): 0; 48.3% identity in 443 aa overlap. FT TBparse score is 0.903." FT /db_xref="GOA:O53512" FT /db_xref="InterPro:IPR002480" FT /db_xref="PDB:2B7O" FT /db_xref="UniProtKB/TrEMBL:O53512" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17482.1" FT /translation="MNWTVDIPIDQLPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQA FT LAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVR FT ALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAARE FT HDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEID FT RGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSAHTVWI FT GERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGN FT HKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHR FT ALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAE FT MLRD" FT CDS complement(16972..17478) FT /transl_table=11 FT /locus_tag="Rv2179c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2179c, (MTV021.12c), len: 168 aa. Conserved FT hypothetical protein, equivalent to conserved hypothetical FT protein from Mycobacterium leprae ML0895 conserved FT hypothetical protein (171 aa). FASTA scores: opt: 977, E(): FT 1.4e-58; 82.530% identity in 166 aa overlap (AL022602). FT TBparse score is 0.912" FT /db_xref="UniProtKB/TrEMBL:O53513" FT /protein_id="CAA17483.1" FT /translation="MRYFYDTEFIEDGHTIELISIGVVAEDGREYYAVSTEFDPERAGS FT WVRTHVLPKLPPPASQLWRSRQQIRLDLEEFLRIDGTDSIELWAWVGAYDHVALCQLWG FT PMTALPPTVPRFTRELRQLWEDRGCPRMPPRPRDVHDALVDARDQLRRFRLITSTDDAG FT RGAAR" FT CDS complement(17488..18375) FT /transl_table=11 FT /locus_tag="Rv2180c" FT /product="Probable conserved integral membrane protein" FT /function="UNKNOWN" FT /note="Rv2180c, (MTV021.13c), len: 295 aa. Probable FT conserved integral membrane protein, similar to pir||T35292 FT probable integral membrane protein from Streptomyces FT coelicolor >gi|5578858|emb|CAB51260.1| (AL096872) (246 aa) FT (36% identity in 249 aa overlap). TBparse score is 0.914" FT /db_xref="UniProtKB/TrEMBL:O53514" FT /protein_id="CAA17484.1" FT /translation="MEVFHWLQHDIVDRGRLPLLCCLVAFVLTFLVTRSFVRFIHRRAA FT DGRPARWWQPRNVHIGSVHIHHVAFGVVLVMISGLTLVTLSVDGREPEFTIAASIFGVG FT AALVLDEYALILHLSDVYWEEDGRTSVDAVFAAVAVAGLLIMGLHPLIFFLPVRQGANW FT VVLQTTLIAGLVLTLPLAVVVLLKGKVWTGLLGMFVVVLLVVGAVRLSRPHAPWARWRY FT TRHPEKMRRALQRERTWRRPVVRIKLWLQYVIAGTPRMPDERAVDAQLDQDVRPAPPPE FT RTAPILISGSVWSD" FT CDS 18463..19746 FT /transl_table=11 FT /locus_tag="Rv2181" FT /product="Probable conserved integral membrane protein" FT /function="UNKNOWN" FT /note="Rv2181, (MTV021.14), len: 427 aa. Probable conserved FT integral membrane protein, similar to others in FT Mycobacterium tuberculosis e.g. Rv1159 (MTCI65.26, 431 aa). FT Start uncertain. FASTA scores: Z95584|MTCI65_26 (431 aa) FT opt: 428, E(): 8e-22; 31.2% identity in 407 aa overlap. FT TBparse score is 0.921" FT /db_xref="InterPro:IPR018584" FT /db_xref="UniProtKB/TrEMBL:O53515" FT /protein_id="CAA17485.1" FT /translation="MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRI FT DIDIYQMGARAWLDGRPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPAASVA FT ITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPISSNF FT AFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTA FT LASFAVATLLGFVLAWRDSWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERF FT ALWVAGSLLVLAATIWAMRRVLRAGEPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLV FT IGLLGWRRRNVALAMLSLAGVVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVI FT VVAGLTVTARMTPQRSLTRGLTPAPTAS" FT CDS complement(19747..20490) FT /transl_table=11 FT /locus_tag="Rv2182c" FT /product="1-acylglycerol-3-phosphate O-acyltransferase" FT /function="transfer of fatty acyl groups" FT /EC_number="2.3.1.51" FT /note="Rv2182c, (MTV021.15c), len: 247 aa. Probable FT 1-acylglycerol-3-phosphate O-acyltransferase, similar to FT many e.g. in Streptomyces. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop). FASTA scores: pir||T35503 FT 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) FT homolog SC6E10.16c - Streptomyces coelicolor FT >gi|5689932|emb|CAB51970.1| (AL109661) hypothetical protein FT [Streptomyces coelicolor A3(2)] Length = 262, Expect = FT 6e-61 (54% identity in 215 aa overlap). TBparse score is FT 0.926" FT /db_xref="GOA:O53516" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/TrEMBL:O53516" FT /protein_id="CAA17486.1" FT /translation="MWYYLFKYIFMGPLFTLLGRPKVEGLEYIPSSGPAILASNHLAVA FT DSFYLPLVVRRRIWFLAKSEYFTGTGLKGWINRWFYSVSGQVPIDRTNADSAQGALQTA FT VVLLGQGKLLGMYPEGTRSPDGRLYKGKTGLARLALHTGVPVIPVAMIGTNVVNPPGRK FT MLRFGRVTVRFGKPMDFSRFEGLAGNHFIERAVTDEVIYELMGLSGQEYVDIYAASVKD FT GRNAGGAGANPNSTDAARIPETAAG" FT misc_feature complement(20092..20115) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(20576..20971) FT /transl_table=11 FT /locus_tag="Rv2183c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2183c, (MTV021.16c), len: 131 aa. Conserved FT hypothetical protein, equivalent to Mycobacterium leprae FT hypothetical protein ML0891 (MLCB268.25c, 130 aa). FASTA FT scores: opt: 558, E(): 8.3e-28; 61.832% identity in 131 aa FT overlap >gi|13092963|emb|CAC31272.1| (AL583920) (AL022602). FT TBparse score is 0.895" FT /db_xref="UniProtKB/TrEMBL:O53517" FT /protein_id="CAA17487.1" FT /translation="MSGAHTDVRPELRKLAQAILDGIDPAVRVAAAMASGGGPGTGKCQ FT QVWCPLCALAALVTGEQHPLLTVIADHSLALLEVIRAIVDDIDRSAKPPPEGPPGGGQT FT GASGGENTNGEGSMKSHYQAIPVTIEE" FT CDS complement(20968..22107) FT /transl_table=11 FT /locus_tag="Rv2184c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2184c, (MTV021.17c), len: 379 aa. Conserved FT hypothetical protein, equivalent to hypothetical protein FT ML0890 (415 aa) from Mycobacterium leprae and also shows FT some similarity to other hypothetical proteins. FASTA FT scores: ML0890 opt: 1949; 79.630% identity in 378 aa FT overlap >emb|CAA18692.1| (AL022602) FT >gi|13092962|emb|CAC31271.1| (AL583920) and FT sptr|Q55794|Q55794 HYPOTHETICAL 44.6 kDa PROTEIN. (396 aa) FT opt: 251, E(): 3.3e-09; 25.5% identity in 384 aa overlap. FT TBparse score is 0.920" FT /db_xref="GOA:O53518" FT /db_xref="InterPro:IPR003348" FT /db_xref="UniProtKB/TrEMBL:O53518" FT /protein_id="CAA17488.1" FT /translation="MVVSTDQAHSLGDVLGIAVPPTGQGDPVRVLAYDPEAGGGFLDAL FT ALDTLALLEGRWLHVVETLDRRFPGSELSSIAPEELCALPGIQEVLGLHAVGELAAARR FT WDRIVVDCASTADALRMLTLPATFGLYVERAWPRHRRLSIGADDGRSAVLAELLERIRA FT SVERLSTLLTDGALVSAHLVLTPERVVAAEAVRTLGSLALMGVRVEELLVNQLLVQDEN FT YEYRSLPDHPAFHWYAERIGEQRAVLDDLDATIGDVALVLVPHLAGEPIGPKALGGLLD FT SARRRQGSAPPGPLQPIVDLESGSGLASIYRLRLALPQLDPGTLTLGRADDDLIVSAGG FT MRRRVRLASVLRRCTVLDAHLRGGELTVRFRPNPEVWPT" FT CDS complement(22227..22661) FT /transl_table=11 FT /gene="TB16.3" FT /locus_tag="Rv2185c" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB16.3" FT /function="UNKNOWN" FT /note="Rv2185c, (MTV021.18c), len: 144 aa. TB16.3, FT conserved hypothetical protein, similar to other FT hypothetical actinomycete proteins and equivalent to FT Mycobacterium leprae ML0889 (144 aa). Some similarity to FT Mycobacterium tuberculosis Rv0854, Rv0856, Rv0857, Rv0164 FT and other Mycobacterium leprae proteins. FASTA scores : FT ML0889 opt: 811; 85.417% identity in 144 aa overlap FT (AL022602). TBparse score is 0.927." FT /db_xref="InterPro:IPR005031" FT /db_xref="UniProtKB/TrEMBL:O53519" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17489.1" FT /translation="MADKTTQTIYIDADPGEVMKAIADIEAYPQWISEYKEVEILEADD FT EGYPKRARMLMDAAIFKDTLIMSYEWPEDRQSLSWTLESSSLLKSLEGTYRLAPKGSGT FT EVTYELAVDLAVPMIGMLKRKAERRLIDGALKDLKKRVEG" FT CDS complement(22766..23155) FT /transl_table=11 FT /locus_tag="Rv2186c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2186c, (MTV021.19c), len: 129 aa. Conserved FT hypothetical protein, equivalent to hypothetical FT Mycobacterium leprae protein ML0888 (135 aa). FASTA scores: FT ML0888 opt: 704, E(): 2.9e-43; 80.000% identity in 130 aa FT overlap CAA18694.1| (AL022602). TBparse score is 0.927" FT /db_xref="UniProtKB/TrEMBL:O53520" FT /protein_id="CAA17490.1" FT /translation="MNSIQIADETYVAADAARVSAAVADRCSWRRWWPDLRLQVTEDRA FT DKGIRWTVTGALTGTMEIWLEPSMDGVLLHYFLHAEPTGVAAWQLARMNLARMTHHRRV FT AGKKMAFEVKTVLERSRPIGVSPVT" FT CDS 23321..25123 FT /transl_table=11 FT /gene="fadD15" FT /locus_tag="Rv2187" FT /product="Probable long-chain-fatty-acid-CoA ligase fadD15 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.3" FT /note="Rv2187, (MTV021.20), len: 600 aa. Probable fadD15, FT long-chain-fatty-acid-CoA ligase (EC 6.2.1.3), similar to FT several e.g. P44446|LCFH_HAEIN PUTATIVE FT LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus FT influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E(): FT 0, (31.5% identity in 578 aa overlap); etc. Contains FT PS00455 Putative AMP-binding domain signature. BELONGS TO FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. TBparse score FT is 0.902." FT /db_xref="GOA:O53521" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR013838" FT /db_xref="UniProtKB/TrEMBL:O53521" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17491.1" FT /translation="MREISVPAPFTVGEHDNVAAMVFEHERDDPDYVIYQRLIDGVWTD FT VTCAEAANQIRAAALGLISLGVQAGDRVVIFSATRYEWAILDFAILAVGAVTVPTYETS FT SAEQVRWVLQDSEAVVLFAETDSHATMVAELSGSVPALREVLQIAGSGPNALDRLTEAG FT ASVDPAELTARLAALRSTDPATLIYTSGTTGRPKGCQLTQSNLVHEIKGARAYHPTLLR FT KGERLLVFLPLAHVLARAISMAAFHSKVTVGFTSDIKNLLPMLAVFKPTVVVSVPRVFE FT KVYNTAEQNAANAGKGRIFAIAAQTAVDWSEACDRGGPGLLLRAKHAVFDRLVYRKLRA FT ALGGNCRAAVSGGAPLGARLGHFYRGAGLTIYEGYGLSGTSGGVAISQFNDLKIGTVGK FT PVPGNSLRIADDGELLVRGGVVFSGYWRNEQATTEAFTDGWFKTGDLGAVDEDGFLTIT FT GRKKEIIVTAGGKNVAPAVLEDQLRAHPLISQAVVVGDAKPFIGALITIDPEAFEGWKQ FT RNSKTAGASVGDLATDPDLIAEIDAAVKQANLAVSHAESIRKFRILPVDFTEDTGELTP FT TMKVKRKVVAEKFASDIEAIYNKE" FT misc_feature 23876..23911 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(25154..26311) FT /transl_table=11 FT /locus_tag="Rv2188c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2188c, (MTV021.21c), len: 385 aa. Conserved FT hypothetical protein, possibly glycosyl transferase similar FT to several putative glycosyl transferases and hypothetical FT proteins e.g. P73369. Equivalent to Mycobacterium leprae FT ML0886 putative glycosyl transferase (384 aa). FASTA FT scores: ML0886 (CAA18697.1| (AL022602) ) opt: 2113, E(): FT 1.8e-106; 81.462% identity in 383 aa overlap; FT sptr|P73369|P73369 HYPOTHETICAL 46.2 kDa PROTEIN (404 aa) FT opt: 379, E(): 2.2e-18; 27.5% identity in 397 aa overlap. FT Start changed since first submission, now 14 aa shorter. FT TBparse score is 0.913" FT /db_xref="GOA:O53522" FT /db_xref="InterPro:IPR001296" FT /db_xref="UniProtKB/TrEMBL:O53522" FT /protein_id="CAA17492.2" FT /translation="MSRVLLVTNDFPPRRGGIQSYLGEFVGRLVGSRAHAMTVYAPQWK FT GADAFDDAARAAGYRVVRHPSTVMLPGPTVDVRMRRLIAEHDIETVWFGAAAPLALLAP FT RARLAGASRVLASTHGHEVGWSMLPVARSVLRRIGDGTDVVTFVSSYTRSRFASAFGPA FT ASLEYLPPGVDTDRFRPDPAARAELRKRYRLGERPTVVCLSRLVPRKGQDTLVTALPSI FT RRRVDGAALVIVGGGPYLETLRKLAHDCGVADHVTFTGGVATDELPAHHALADVFAMPC FT RTRGAGMDVEGLGIVFLEASAAGVPVIAGNSGGAPETVQHNKTGLVVDGRSVDRVADAV FT AELLIDRDRAVAMGAAGREWVTAQWRWDTLAAKLADFLRGDDAAR" FT CDS complement(26408..27181) FT /transl_table=11 FT /locus_tag="Rv2189c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2189c, (MTV021.22c), len: 257 aa. Conserved FT hypothetical protein; some similarity to hypothetical FT protein SC6G10.07c (385 aa) from Streptomyces coelicolor FT A3(2). Smith-Waterman scores: pir||T35516 hypothetical FT protein SC6G10.07c - Streptomyces coelicolor FT >gi|4539203|emb|CAB39861.1| (AL049497) Expect = 2e-08; 30% FT identity in 245 aa overlap. TBparse score is 0.908" FT /db_xref="UniProtKB/TrEMBL:O53523" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17493.1" FT /translation="MRDGPAAPAQVVAPADGFVALRVADDRTVRLLSLGGAATDRLLSR FT IAAGIDAAVDEVVAFWGTDWSHDIFVVAAGSDEQFHAAAGGGLASQWADIAAITVVDRV FT DPARRTVVGQRIVFAPGAAHMSPAALRIVLGHELFHYAARADTALDAPRWLAEGVADFV FT ARPKTPPPADAVSVALSLPSDTDLDTPGPQRSLAYDRAWWFARFVAAAYGTAKLRELYL FT ATCGVGHFDLATAAHDVLGIDAAGLLARWQRWLMG" FT CDS complement(27276..28433) FT /transl_table=11 FT /locus_tag="Rv2190c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa. FT Conserved hypothetical protein; similar to other FT hypothetical mycobacterial proteins, including Rv1477, FT Rv1478, Rv1566c, Rv0024, that are similar to protein p60 FT precursors from Listeria e.g. Q018 38|P60_LISSE protein p60 FT precursor (invasion-associated protein) (524 aa). FASTA FT scores: gp|Z80233|MTCY10H4_25 (281 aa) opt: 290, E(): FT 6.9e-05; 37.0% identity in 127 aa overlap and FT sp|Q01838|P60_LISSE PROTEIN P60 PRECURSOR (523 aa) opt: FT 268, E(): 0.00071; 38.5% identity in 104 aa overlap. FT TBparse score is 0.927" FT /db_xref="InterPro:IPR000064" FT /db_xref="UniProtKB/Swiss-Prot:P67473" FT /protein_id="CAA17495.1" FT /translation="MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDALA FT KLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAARARLATFQTAVN FT KVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAHQMSTQMARFKAAGEQAVKAE FT QAAAKSAADARSAAEQAAAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALADPGPV FT PAVAAIAPGAPPAALPPGAPPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAVVQAAL FT TQVGAPYAWGGAAPGGFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPGDVL FT TFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY" FT CDS 28980..30917 FT /transl_table=11 FT /locus_tag="Rv2191" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2191, (MTCY190.02), len: 645 aa. Conserved FT hypothetical protein, similar to SW:DP3A_B ACSU P13267 DNA FT polymerase III, alpha chain (31.3% identity in 249 aa FT overlap) and SW:UVRC_ECOLI P07028 excinuclease ABC subunit FT C (25.7% identity in 230 aa overlap). Also similar to M. FT tuberculosis Rv3711c (dnaQ DNA polymerase III e chain) and FT Rv1420 (uvrC excinuclease ABC subunit C)" FT /db_xref="GOA:Q10384" FT /db_xref="InterPro:IPR000305" FT /db_xref="UniProtKB/Swiss-Prot:Q10384" FT /protein_id="CAA94260.1" FT /translation="MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFVV FT VDLETTGGRTTGNDATPPDAITEIGAVKVCGGAVLGEFATLVNPQHSIPPQIVRLTGIT FT TAMVGNAPTIDAVLPMFFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLCTMR FT LARRVLSRDEAPSVRLAALARLFAVASNPTHRALDDARATVDVLHALIERVGNQGVHTY FT AELRSYLPNVTQAQRCKRVLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVSQYFNG FT TDRRKRMTEMVMLASSIDHVECAHPLEAGVRELRMLSTHAPPYNRRSKFPYRWWWVALT FT DEAFPRLSVIRAPRHDRVVGPFRSRSKAAETAALLARCTGLRTCTTRLTRSARHGPACP FT ELEVSACPAARDVTAAQYAEAVLRAAALIGGLDNAALAAAVQQVTELAERRRYESAARL FT RDHLATAIEALWHGQRLRALAALPELIAAKPDGPREGGYQLAVIRHGQLAAAGRAPRGV FT PPMPVVDAIRRGAQAILPTPAPLGGALVEEIALIARWLAEPGVRIVGVSNDAAGLASPV FT RSAGPWAAWAATARSAQLAGEQLSRGWQSDLPTEPHPSREQLFGRTGVDCRTGPPQPLL FT PGRQPFSTAG" FT CDS complement(30792..31904) FT /transl_table=11 FT /gene="trpD" FT /locus_tag="Rv2192c" FT /product="Probable anthranilate phosphoribosyltransferase FT TrpD" FT /function="tryptophan biosynthesis" FT /EC_number="2.4.2.18" FT /note="Rv2192c, (MTCY190.03c), len: 370 aa. Probable trpD, FT anthranilate phosphoribosyltransferase (EC 2.4.2.18) (see FT citation below), similar to e.g. TRPD_LACCA|P17170, (43.2% FT identity in 308 aa overlap). Initiation codon uncertain, FT gtg at 4086 in MTCY190 favoured by homology but this has no FT clear ribosome binding site." FT /db_xref="GOA:P66992" FT /db_xref="InterPro:IPR017459" FT /db_xref="PDB:1ZVW" FT /db_xref="UniProtKB/Swiss-Prot:P66992" FT /protein_id="CAA94261.1" FT /translation="MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQA FT AWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVD FT VVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPD FT LVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCA FT FADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGF FT ARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAW FT EEGLRRASAAIDTGAAEQLLARWVRFGRQI" FT CDS 32062..32673 FT /transl_table=11 FT /gene="ctaE" FT /locus_tag="Rv2193" FT /product="PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE" FT /function="THOUGHT TO BE INVOLVED IN AEROBIC RESPIRATION." FT /EC_number="1.9.3.1" FT /note="Rv2193, (MTCY190.04), len: 203 aa. Probable ctaE, FT cytochrome c oxidase polypeptide III (cox3) (EC 1.9.3.1), FT with strong similarity to others e.g. COX3_SYNY3|Q06475 FT (29.8% identity in 225 aa overlap)." FT /db_xref="GOA:P63856" FT /db_xref="InterPro:IPR013833" FT /db_xref="UniProtKB/Swiss-Prot:P63856" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94262.1" FT /translation="MTSAVGTSGTAITSRVHSLNRPNMVSVGTIVWLSSELMFFAGLFA FT FYFSARAQAGGNWPPPPTELNLYQAVPVTLVLIASSFTCQMGVFAAERGDIFGLRRWYV FT ITFLMGLFFVLGQAYEYRNLMSHGTSIPSSAYGSVFYLATGFHGLHVTGGLIAFIFLLV FT RTGMSKFTPAQATASIVVSYYWHFVDIVWIALFTVIYFIR" FT CDS 32714..33556 FT /transl_table=11 FT /gene="qcrC" FT /locus_tag="Rv2194" FT /product="Probable Ubiquinol-cytochrome C reductase FT QcrC(cytochrome C subunit)" FT /function="respiration" FT /note="Rv2194, (MTCY190.05), len: 280 aa. Probable qcrC, FT Ubiquinol-cytochrome C reductase cytochrome C subunit FT (cyoA), shows similarity to cytochrome c family; contains 2 FT X PS00190 Cytochrome c family heme-binding site signature." FT /db_xref="GOA:P63887" FT /db_xref="HSSP:1C6S" FT /db_xref="InterPro:IPR009152" FT /db_xref="UniProtKB/Swiss-Prot:P63887" FT /protein_id="CAA94263.1" FT /translation="MTKLGFTRSGGSKSGRTRRRLRRRLSGGVLLLIALTIAGGLAAVL FT TPTPQVAVADESSSALLRTGKQLFDTSCVSCHGANLQGVPDHGPSLIGVGEAAVYFQVS FT TGRMPAMRGEAQAPRKDPIFDEAQIDAIGAYVQANGGGPTVVRNPDGSIATQSLRGNDL FT GRGGDLFRLNCASCHNFTGKGGALSSGKYAPDLAPANEQQILTAMLTGPQNMPKFSNRQ FT LSFEAKKDIIAYVKVATEARQPGGYLLGGFGPAPEGMAMWIIGMVAAIGLALWIGARS" FT CDS 33553..34842 FT /transl_table=11 FT /gene="qcrA" FT /locus_tag="Rv2195" FT /product="Probable Rieske iron-sulfur protein QcrA" FT /function="respiration" FT /note="Rv2195, (MTCY190.06), len: 429 aa. Probable qcrA, FT Ubiquinol-cytochrome C reductase iron-sulfur subunit FT (cyoB), shows some similarity to cytochrome B6-F complex FT iron-sulphur subunits (Rieske iron-sulfur protein); FT contains PS00200 Rieske iron-sulfur protein signature 2" FT /db_xref="GOA:Q10387" FT /db_xref="InterPro:IPR017941" FT /db_xref="UniProtKB/Swiss-Prot:Q10387" FT /protein_id="CAA94264.1" FT /translation="MSRADDDAVGVPPTCGGRSDEEERRIVPGPNPQDGAKDGAKATAV FT PREPDEAALAAMSNQELLALGGKLDGVRIAYKEPRWPVEGTKAEKRAERSVAVWLLLGG FT VFGLALLLIFLFWPWEFKAADGESDFIYSLTTPLYGLTFGLSILSIAIGAVLYQKRFIP FT EEISIQERHDGASREIDRKTVVANLTDAFEGSTIRRRKLIGLSFGVGMGAFGLGTLVAF FT AGGLIKNPWKPVVPTAEGKKAVLWTSGWTPRYQGETIYLARATGTEDGPPFIKMRPEDM FT DAGGMETVFPWRESDGDGTTVESHHKLQEIAMGIRNPVMLIRIKPSDLGRVVKRKGQES FT FNFGEFFAFTKVCSHLGCPSSLYEQQSYRILCPCHQSQFDALHFAKPIFGPAARALAQL FT PITIDTDGYLVANGDFVEPVGPAFWERTTT" FT repeat_region 33553..33610 FT /note="58 bp Mycobacterial Interspersed Repetitive Unit, FT Class II I. Overlaps Rv2195 suggesting alternative GTG FT start at 2458 468 may be used" FT CDS 34839..36488 FT /transl_table=11 FT /gene="qcrB" FT /locus_tag="Rv2196" FT /product="Probable Ubiquinol-cytochrome C reductase QcrB FT (cytochrome B subunit)" FT /function="respiration" FT /note="Rv2196, (MTCY190.07), len: 549 aa. Probable qcrB, FT Ubiquinol-cytochrome C reductase cytochrome B subunit FT (cytB), integral membrane protein, low similarity in FT amino-terminal half to cytochrome b subunits, highly FT similar at C-terminus to SW:12KD_MYCLE P15878 12 KD protein FT PIR:S08427 (86.9% identity in 153 aa overlap). FASTA FT scores: sp|Q45658|QCRB_BACST MENAQUINOL-CYTOCHROME C FT REDUCTASE (224 aa) opt: 341, E(): 6.8e-15; 28.0% identity FT in 207 aa overlap" FT /db_xref="GOA:P63885" FT /db_xref="InterPro:IPR005797" FT /db_xref="UniProtKB/Swiss-Prot:P63885" FT /protein_id="CAA94265.1" FT /translation="MSPKLSPPNIGEVLARQAEDIDTRYHPSAALRRQLNKVFPTHWSF FT LLGEIALYSFVVLLITGVYLTLFFDPSMVDVTYNGVYQPLRGVEMSRAYQSALDISFEV FT RGGLFVRQIHHWAALMFAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEGYFG FT YSLPDDLLSGLGLRAALSSITLGMPVIGTWLHWALFGGDFPGTILIPRLYALHILLLPG FT IILALIGLHLALVWFQKHTQFPGPGRTEHNVVGVRVMPVFAFKSGAFFAAIVGVLGLMG FT GLLQINPIWNLGPYKPSQVSAGSQPDFYMMWTEGLARIWPPWEFYFWHHTIPAPVWVAV FT IMGLVFVLLPAYPFLEKRFTGDYAHHNLLQRPRDVPVRTAIGAMAIAFYMVLTLAAMND FT IIALKFHISLNATTWIGRIGMVILPPFVYFITYRWCIGLQRSDRSVLEHGVETGIIKRL FT PHGAYIELHQPLGPVDEHGHPIPLQYQGAPLPKRMNKLGSAGSPGSGSFLFADSAAEDA FT ALREAGHAAEQRALAALREHQDSIMGSPDGEH" FT CDS complement(36665..37309) FT /transl_table=11 FT /locus_tag="Rv2197c" FT /product="Probable conserved transmembrane protein" FT /function="UNKNOWN" FT /note="Rv2197c, (MTCY190.08c), len: 214 aa. Probable FT conserved transmembrane protein, equivalent to ML0878 FT conserved hypothetical protein (212 aa) of Mycobacterium FT leprae. FASTA scores: opt: 858; 62.559% identity in 211 aa FT overlap CAC31259.1|(AL583920)" FT /db_xref="GOA:Q10389" FT /db_xref="UniProtKB/Swiss-Prot:Q10389" FT /protein_id="CAA94266.1" FT /translation="MVSRYSAYRRGPDVISPDVIDRILVGACAAVWLVFTGVSVAAAVA FT LMDLGRGFHEMAGNPHTTWVLYAVIVVSALVIVGAIPVLLRARRMAEAEPATRPTGASV FT RGGRSIGSGHPAKRAVAESAPVQHADAFEVAAEWSSEAVDRIWLRGTVVLTSAIGIALI FT AVAAATYLMAVGHDGPSWISYGLAGVVTAGMPVIEWLYARQLRRVVAPQSS" FT CDS complement(37309..38208) FT /transl_table=11 FT /gene="mmpS3" FT /locus_tag="Rv2198c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS3" FT /function="UNKNOWN" FT /note="Rv2198c, (MTCY190.09c), len: 301 aa. Probable mmpS3, FT conserved membrane protein (see citation below), equivalent FT to ML0877|mmpS3 putative membrane protein from FT Mycobacterium leprae (293 aa), FASTA scores: opt: 1089, FT E(): 1.2e-43, (69.80% identity in 308 aa overlap). Also FT similar to other proteins e.g. Rv3209 from Mycobacterium FT tuberculosis. Contains PS00499 C2 domain signature, a FT hydrophobic region, and a repetitive proline and threonine FT rich region. BELONGS TO THE MMPS FAMILY." FT /db_xref="GOA:P65378" FT /db_xref="UniProtKB/Swiss-Prot:P65378" FT /protein_id="CAA94267.1" FT /translation="MSGPNPPGREPDEPESEPVSDTGDERASGNHLPPVAGGGDKLPSD FT QTGETDAYSRAYSAPESEHVTGGPYVPADLRLYDYDDYEESSDLDDELAAPRWPWVVGV FT AAIIAAVALVVSVSLLVTRPHTSKLATGDTTSSAPPVQDEITTTKPAPPPPPPAPPPTT FT EIPTATETQTVTVTPPPPPPPATTTAPPPATTTTAAAPPPTTTTPTGPRQVTYSVTGTK FT APGDIISVTYVDAAGRRRTQHNVYIPWSMTVTPISQSDVGSVEASSLFRVSKLNCSITT FT SDGTVLSSNSNDGPQTSC" FT CDS complement(38394..38813) FT /transl_table=11 FT /locus_tag="Rv2199c" FT /product="Possible conserved integral membrane protein" FT /function="UNKNOWN" FT /note="Rv2199c, (MTCY190.10c), len: 139 aa. Possible FT conserved integral membrane protein, similar to FT hypothetical membrane proteins in Actinomycetes and FT equivalent to Mycobacterium leprae, ML0876, putative FT membrane protein (139 aa) FASTA scores: opt: 866, E(): FT 1.1e-43; 91.367% identity in 139 aa overlap CAC31257.1| FT (AL583920)" FT /db_xref="GOA:P64947" FT /db_xref="UniProtKB/Swiss-Prot:P64947" FT /protein_id="CAA94268.1" FT /translation="MHIEARLFEFVAAFFVVTAVLYGVLTSMFATGGVEWAGTTALALT FT GGMALIVATFFRFVARRLDSRPEDYEGAEISDGAGELGFFSPHSWWPIMVALSGSVAAV FT GIALWLPWLIAAGVAFILASAAGLVFEYYVGPEKH" FT CDS complement(38821..39912) FT /transl_table=11 FT /gene="ctaC" FT /locus_tag="Rv2200c" FT /product="PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE FT (SUBUNIT II) CTAC" FT /function="INVOLVED IN AEROBIC RESPIRATION. SUBUNIT I AND FT II FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. FT ELECTRONS ORIGINATING IN CYTOCHROME C ARE TRANSFERRED VIA FT HEME A AND CU(A) TO THE BINUCLEAR CENTER FORMED BY HEME A3 FT AND CU(B) (BY SIMILARITY)." FT /EC_number="1.9.3.1" FT /note="Rv2200c, (MTCY190.11c), len: 363 aa. Probable ctaC, FT transmembrane cytochrome C oxidase (subunit II), COX2, FT similar e.g. to JT0964 cytochrome-c oxidase chain II (23.0% FT identity in 317 aa overlap); etc. Contains PS00078 FT Cytochrome c oxidase subunit II, copper A binding region FT signature. BELONGS TO THE CYTOCHROME C OXIDASE SUBUNIT 2 FT FAMILY." FT /db_xref="GOA:P63854" FT /db_xref="InterPro:IPR002429" FT /db_xref="UniProtKB/Swiss-Prot:P63854" FT /protein_id="CAA94269.1" FT /translation="MTPRGPGRLQRLSQCRPQRGSGGPARGLRQLALAAMLGALAVTVS FT GCSWSEALGIGWPEGITPEAHLNRELWIGAVIASLAVGVIVWGLIFWSAVFHRKKNTDT FT ELPRQFGYNMPLELVLTVIPFLIISVLFYFTVVVQEKMLQIAKDPEVVIDITSFQWNWK FT FGYQRVNFKDGTLTYDGADPERKRAMVSKPEGKDKYGEELVGPVRGLNTEDRTYLNFDK FT VETLGTSTEIPVLVLPSGKRIEFQMASADVIHAFWVPEFLFKRDVMPNPVANNSVNVFQ FT IEEITKTGAFVGHCAEMCGTYHSMMNFEVRVVTPNDFKAYLQQRIDGKTNAEALRAINQ FT PPLAVTTHPFDTRRGELAPQPVG" FT CDS 40158..42116 FT /transl_table=11 FT /gene="asnB" FT /locus_tag="Rv2201" FT /product="Probable asparagine synthetase AsnB" FT /function="asparagine biosynthesis" FT /EC_number="6.3.5.4" FT /note="Rv2201, (MTCY190.12), len: 652 aa. Probable asnB, FT asparagine synthetase, similar to e.g. SW:ASNH_BACSU P42113 FT putative asparagine synthetase (26.0% identity in 438 aa FT overlap)" FT /db_xref="GOA:P64247" FT /db_xref="HSSP:1CT9" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:P64247" FT /protein_id="CAA94270.1" FT /translation="MCGLLAFVAAPAGAAGPEGADAASAIARASHLMRHRGPDESGTWH FT AVDGASGGVVFGFNRLSIIDIAHSHQPLRWGPPEAPDRYVLVFNGEIYNYLELRDELRT FT QHGAVFATDGDGEAILAGYHHWGTEVLQRLRGMFAFALWDTVTRELFCARDPFGIKPLF FT IATGAGGTAVASEKKCLLDLVELVGFDTEIDHRALQHYTVLQYVPEPETLHRGVRRLES FT GCFARIRADQLAPVITRYFVPRFAASPITNDNDQARYDEITAVLEDSVAKHMRADVTVG FT AFLSGGIDSTAIAALAIRHNPRLITFTTGFEREGFSEIDVAVASAEAIGARHIAKVVSA FT DEFVAALPEIVWYLDEPVADPALVPLFFVAREARKHVKVVLSGEGADELFGGYTIYREP FT LSLRPFDYLPKPLRRSMGKVSKPLPEGMRGKSLLHRGSLTLEERYYGNARSFSGAQLRE FT VLPGFRPDWTHTDVTAPVYAESAGWDPVARMQHIDLFTWLRGDILVKADKITMANSLEL FT RVPFLDPEVFAVASRLPAGAKITRTTTKYALRRALEPIVPAHVLHRPKLGFPVPIRHWL FT RAGELLEWAYATVGSSQAGHLVDIAAVYRMLDEHRCGSSDHSRRLWTMLIFMLWHAIFV FT EHSVVPQISEPQYPVQL" FT CDS complement(42214..43188) FT /transl_table=11 FT /gene="cbhK" FT /locus_tag="Rv2202c" FT /product="Probable carbohydrate kinase CbhK" FT /function="phosphorylation of carbohydrates" FT /EC_number="2.7.-.-" FT /note="Rv2202c, (MTCY190.13c), len: 324 aa. Probable cbhK, FT carbohydrate kinase (but not ribose) (EC 2.7.-.-), similar FT to several e.g. AE000915_1 Methanobacterium thermoautotrop FT (309 aa) FASTA score: opt: 370, E(): 3.3e-18; 31.2% FT identity in 276 aa overlap. Low similarity to carbohydrate FT kinases, e.g. SW:RBSK_BACSU P36945 ribokinase (23.9% FT identity in 272 aa overlap); contains PS00583 pfkB family FT of carbohydrate kinases signature 1" FT /db_xref="GOA:P83734" FT /db_xref="InterPro:IPR002173" FT /db_xref="PDB:2PKF" FT /db_xref="UniProtKB/Swiss-Prot:P83734" FT /protein_id="CAA94245.1" FT /translation="MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMH FT RGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTC FT TTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLG FT LAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVT FT TLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGS FT LVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAVLA" FT CDS 43392..44084 FT /transl_table=11 FT /locus_tag="Rv2203" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2203, (MTCY190.14), len: 230 aa. Possible FT conserved membrane protein; has single hydrophobic stretch FT from aa 75 to 97 and is equivalent to Mycobacterium leprae FT ML0872 putative membrane protein (171 aa). FASTA scores: FT opt: 821, E(): 3.4e-42; 72.353% identity in 170 aa overlap FT - CAC31253.1| (AL583920). 2468411." FT /db_xref="GOA:P64949" FT /db_xref="UniProtKB/Swiss-Prot:P64949" FT /protein_id="CAA94246.1" FT /translation="MPGPHSPNPGVGTNGPAPYPEPSSHEPQALDYPHDLGAAEPAFAP FT GPADDAALPPAAYPGVPPQVSYPKRRHKRLLIGIVVALALVSAMTAAIIYGVRTNGANT FT AGTFSEGPAKTAIQGYLNALENRDVDTIVRNALCGIHDGVRDKRSDQALAKLSSDAFRK FT QFSQVEVTSIDKIVYWSQYQAQVLFTMQVTPAAGGPPRGQVQGIAQLLFQRGQVLVCSY FT VLRTAGSY" FT CDS complement(44092..44448) FT /transl_table=11 FT /locus_tag="Rv2204c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2204c, (MTCY190.15c), len: 118 aa. Conserved FT hypothetical protein. Similar to conserved hypothetical FT proteins in Actinomycetes and equivalent to Mycobacterium FT leprae ML0871|ML0871 conserved hypothetical protein (118 FT aa) and to sp|P45344|YADR_HAEIN HYPOTHETICAL PROTEIN HI1723 FT (114 aa). FASTA score: ML0871 opt: 720, E(): 8.4e-45; FT 92.373% identity in 118 aa overlapCAC31252.1| (AL583920); FT and P45344 opt: 346, E(): 1.8e-18; 45.6% identity in 103 aa FT overlap. Contains PS01152 Hypothetical hesB/y yadR/yfhF FT family signature" FT /db_xref="GOA:P0A5A9" FT /db_xref="HSSP:1NWB" FT /db_xref="InterPro:IPR017870" FT /db_xref="UniProtKB/Swiss-Prot:P0A5A9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94247.1" FT /translation="MTVQNEPSAKTHGVILTEAAAAKAKSLLDQEGRDDLALRIAVQPG FT GCAGLRYNLFFDDRTLDGDQTAEFGGVRLIVDRMSAPYVEGASIDFVDTIEKQGFTIDN FT PNATGSCACGDSFN" FT CDS complement(44548..45624) FT /transl_table=11 FT /locus_tag="Rv2205c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2205c, (MTCY190.16c), len: 358 aa. Conserved FT hypothetical protein. Very similar to YHAD_ECOLI|P23524 FT hypothetical protein (YHAD (E.coli) / YXAA (S14A) FT (B.subtilis) family) (41.6% identity in 154 aa overlap), FT and to other members of the glycerate kinase family. Start FT changed since first submission; protein now 122 aa shorter, FT owing to extension of Rv2206." FT /db_xref="GOA:P64288" FT /db_xref="InterPro:IPR004381" FT /db_xref="UniProtKB/Swiss-Prot:P64288" FT /protein_id="CAA94248.2" FT /translation="MRVLVAPDCYGDSLSAVEAAAAIATGWTRSRPGDSFIVAPQSDGG FT PGFVEVLGSRLGETRRLRVCGPLNTVVNAAWVFDPGSATAYLECAQACGLGLLGGPPTP FT ETALAAHSKGVGQLIAAALRAGAARIVVGLGGSACTDGGKGMIAELGGLDAARRQLADV FT EVIAASDVEYPLLGPWGTARVFAPQKGADMATVAVLEGRLAAWAIELDAAAGRGVSAEP FT GAGAAGGIGAGLLAVGGRYQSGAAIIAEHTHFADDLADAELIVTGEGRFDEQSLHGKVV FT GAIAAAARPLAIPVIVLAGQVSLDKSALRSAGIMAALSIAEYAGSVRLALADAANQLMG FT LASQVAARLGNSGPSGYR" FT CDS 45783..46493 FT /transl_table=11 FT /locus_tag="Rv2206" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2206, (MTCY190.17), len: 236 aa. Probable FT conserved transmembrane protein. Equivalent to hypothetical FT protein ML0869 (247 aa) of Mycobacterium leprae FT gZ98741|MLCB22_2 (247 aa), FASTA scores: opt: 1052, (67.5% FT identity in 237 aa overlap). Two hydrophobic stretches in FT C-terminal part. Start changed since original submission FT (+112 aa)." FT /db_xref="GOA:P64951" FT /db_xref="UniProtKB/Swiss-Prot:P64951" FT /protein_id="CAA94249.2" FT /translation="MKLLGHRKSHGHQRADASPDAGSKDGCRPDSGRTSGSDTSRGSQT FT TGPKGRPTPKRNQSRRHTKKGPVAPAPMTAAQARARRKSLAGPKLSREERRAEKAANRA FT RMTERRERMMAGEEAYLLPRDRGPVRRYVRDVVDSRRNLLGLFMPSALTLLFVMFAVPQ FT VQFYLSPAMLILLALMTIDAIILGRKVGRLVDTKFPSNTESRWRLGLYAAGRASQIRRL FT RAPRPQVERGGDVG" FT CDS 46572..47657 FT /transl_table=11 FT /gene="cobT" FT /locus_tag="Rv2207" FT /product="Probable FT nicotinate-nucleotide-dimethylbenzimidazol FT phosphoribosyltransferase CobT" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS" FT /EC_number="2.4.2.21" FT /note="Rv2207, (MTCY190.18), len: 361 aa. Probable cobT, FT phosphoribosyltransferase, similar to many e.g. FT SW:COBT_ECOLI P36562 FT nicotinate-nucleotide--dimethylbenzimidazol FT phosphoribosyltransferase (34.6% identity in 341 aa FT overlap)" FT /db_xref="GOA:P63841" FT /db_xref="HSSP:1D0V" FT /db_xref="InterPro:IPR017846" FT /db_xref="UniProtKB/Swiss-Prot:P63841" FT /protein_id="CAA94250.1" FT /translation="MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASC FT QQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVAGA FT TVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEVDAG FT ADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVR FT PVLPDPVGLLRCAGGADLAAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRW FT WQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTE FT AGVSTRSVDGVDRTAPPAVSP" FT CDS 47654..48403 FT /transl_table=11 FT /gene="cobS" FT /locus_tag="Rv2208" FT /product="Probable cobalamin 5'-phosphate synthase CobS" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS" FT /EC_number="2.-.-.-" FT /note="Rv2208, (MTCY190.19), len: 249 aa. Probable cobS, FT cobalamin 5'-phosphate synthase; similarity to FT SW:COBS_ECOLI P36561 cobalamin (5'-phosphate) synthase FT (28.0% identity in 243 aa overlap)" FT /db_xref="GOA:Q10397" FT /db_xref="InterPro:IPR003805" FT /db_xref="UniProtKB/Swiss-Prot:Q10397" FT /protein_id="CAA94251.1" FT /translation="MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAA FT AIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRD FT GSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGST FT LGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGG FT VTGDVLGSAIELSTTVSAVTLAGLARL" FT CDS 48561..50099 FT /transl_table=11 FT /locus_tag="Rv2209" FT /product="Probable conserved integral membrane protein" FT /function="UNKNOWN" FT /note="Rv2209, (MTCY190.20), len: 512 aa. Probable FT conserved integral membrane protein, similar to but longer FT than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium FT tuberculosis (436 aa). FASTA score: opt: 712, E(): 2.8e- FT 32; 33.4% identity in 422 aa overlap" FT /db_xref="GOA:P64953" FT /db_xref="UniProtKB/Swiss-Prot:P64953" FT /protein_id="CAA94252.1" FT /translation="MPASRLVRQVSAPRNLFGRLVAQGGFYTAGLQLGSGAVVLPVICA FT HQGLTWAAGLLYPAFCIGAILGNSLSPLILQRAGQLRHLLMAAISATAAALVVCNAAVP FT WTGVGVAAVFLATTGAGGVVTGVSSVAYTDMISSMLPAVRRGELLLTQGAAGSVLATGV FT TLVIVPMLAHGNEMARYHDLLWLGAAGLVCSGIAALFVGPMRSVSVTTATRMPLREIYW FT MGFAIARSQPWFRRYMTTYLLFVPISLGTTFFSLRAAQSNGSLHVLVILSSIGLVVGSM FT LWRQINRLFGVRGLLLGSALLNAAAALLCMVAESCGQWVHAWAYGTAFLLATVAAQTVV FT AASISWISVLAPERYRATLICVGSTLAAVEATVLGVALGGIAQKHATIWPVVVVLTLAV FT IAAVASLRAPTRIGVTADTSPQAATLQAYRPATPNPIHSDERSTPPDHLSVRRGQLRHV FT WDSRRPAPPLNRPSCRRAARRPAPGKPAAALPQPRHPAVGVREGAPLDAGQRIA" FT CDS complement(50025..51131) FT /transl_table=11 FT /gene="ilvE" FT /locus_tag="Rv2210c" FT /product="PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE FT ILVE" FT /function="THOUGHT TO CATALYZE THE FIRST REACTION IN THE FT CATABOLISM OF THE ESSENTIAL BRANCHED CHAIN AMINO ACIDS FT LEUCINE, ISOLEUCINE, AND VALINE [CATALYTIC ACTIVITY: FT L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + FT L-glutamate]." FT /EC_number="2.6.1.42" FT /note="Rv2210c, (MTCY190.21c), len: 368 aa. Probable ilvE, FT Branched-chain-amino-acid transaminase, highly similar to FT many e.g. YWAA_BACSU|P39576 from Bacillus subtilis (48.4% FT identity in 339 aa overlap); etc." FT /db_xref="GOA:Q10399" FT /db_xref="HSSP:1KT8" FT /db_xref="InterPro:IPR005786" FT /db_xref="UniProtKB/Swiss-Prot:Q10399" FT /protein_id="CAA94253.1" FT /translation="MTSGSLQFTVLRAVNPATDAQRESMLREPGFGKYHTDHMVSIDYA FT EGRGWHNARVIPYGPIELDPSAIVLHYAQEVFEGLKAYRWADGSIVSFRADANAARLRS FT SARRLAIPELPDAVFIESLRQLIAVDKAWVPGAGGEEALYLRPFIFATEPGLGVRPATQ FT YRYLLIASPAGAYFKGGIAPVSVWVSTEYVRACPGGTGAAKFGGNYAASLLAQAEAAEN FT GCDQVVWLDAVERRYIEEMGGMNIFFVLGSGGSARLVTPELSGSLLPGITRDSLLQLAI FT DAGFAVEERRIDIDEWQKKAAAGEITEVFACGTAAVITPVARVRHGASEFRIADGQPGE FT VTMALRDTLTGIQRGTFADTHGWMARLG" FT CDS complement(51203..52342) FT /transl_table=11 FT /gene="gcvT" FT /locus_tag="Rv2211c" FT /product="Probable aminomethyltransferase GcvT (Glycine FT cleavage system T protein)" FT /function="The glycine cleavage system catalyzes the FT degradation of glycine [CATALYTIC ACTIVITY: FT (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = FT (6R)-5,10-methylenetetrahydrofolate + NH3 + FT dihydrolipoylprotein]." FT /EC_number="2.1.2.10" FT /note="Rv2211c, (MTCY190.22), len: 379 aa. Probable gcvT, FT aminomethyltransferase (EC 2.1.2.10), similar to many e.g. FT GCST_ECOLI|P27248 for Escherichia coli (38.2% identity in FT 364 aa overlap); etc. BELONGS TO THE GCVT FAMILY." FT /db_xref="GOA:P64220" FT /db_xref="InterPro:IPR006223" FT /db_xref="UniProtKB/Swiss-Prot:P64220" FT /protein_id="CAA94254.1" FT /translation="MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPV FT SYAGTVSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQYTLC FT CTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAVLAV FT QGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVF FT DALLAAVSAAGGEPAGLGARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFF FT GRAALLAEKAAGPRRLLRGLRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGL FT ALIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR" FT CDS 52351..53487 FT /transl_table=11 FT /locus_tag="Rv2212" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2212, (MTCY190.23), len: 378 aa. Conserved FT hypothetical protein. Some similarity to adenylate FT cyclases, e.g. SW:CYAA_STRCO P40135 (29.2% identity in 291 FT aa overlap); ttg at 24614 in MTCY190 has a better rbs. FT Contains possible helix-turn-helix motif at aa 64- 85, FT (+2.72 SD). Also similar to Rv1264 and Rv1647" FT /db_xref="GOA:P64265" FT /db_xref="HSSP:1AWK" FT /db_xref="InterPro:IPR001054" FT /db_xref="UniProtKB/Swiss-Prot:P64265" FT /protein_id="CAA94255.1" FT /translation="MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRG FT RLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVD FT ALATWVALKALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATAR FT AYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQ FT ALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPG FT ARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPA FT LAHGPLTLKGFDAPVMAFELHDNPRARDADTPSPAASD" FT CDS 53499..55046 FT /transl_table=11 FT /gene="pepB" FT /locus_tag="Rv2213" FT /product="Probable aminopeptidase PepB" FT /function="protein degradation" FT /EC_number="3.4.11.1" FT /note="Rv2213, (MTCY190.24), len: 515 aa. Probable pepB, FT leucine aminopeptidase, similar to many e.g. SW:AMPA_ECOLI FT P11648 aminopeptidase A/I, (41.4% identity in 309 aa FT overlap). Equivalent to Z98741|MLCB22_6 Mycobacterium FT leprae cosmid B22; Am (524 aa), FASTA scores: opt: 2793, FT E(): 0; 83.1% identity in 522 aa overlap. Contains PS00631 FT Cytosol aminopeptidase signature, NTDAEGRL" FT /db_xref="GOA:Q10401" FT /db_xref="HSSP:1GYT" FT /db_xref="InterPro:IPR008283" FT /db_xref="UniProtKB/Swiss-Prot:Q10401" FT /protein_id="CAA94271.1" FT /translation="MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVV FT ASAEPFLRADTVAEIEAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPAD FT TIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDA FT GLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVG FT LDVEVIDEKALKKAGYGGVIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGI FT TFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATA FT QRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGT FT RIPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLV FT AGVFLREFVAESVDWAHIDVAGPAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG" FT CDS complement(55084..56862) FT /transl_table=11 FT /gene="ephD" FT /locus_tag="Rv2214c" FT /product="Possible short-chain dehydrogenase EphD" FT /function="THOUGHT TO BE INVOLVED IN DETOXIFICATION FT REACTIONS FOLLOWING OXIDATIVE DAMAGE TO LIPIDS." FT /EC_number="1.-.-.-" FT /note="Rv2214c, (MTCY190.25c), len: 592 aa. Possible ephD, FT short-chain dehydrogenase (EC 1.-.-.-) (see citation FT below), equivalent to Z98741|MLCB22_8 Mycobacterium leprae FT cosmid B22; (596 aa), FASTA score: opt: 3262, E(): 0; 80.4% FT identity in 596 aa overlap. C-terminus similar to FT short-chain alcohol dehydrogenase family, similar to FT SW:LIGD_PSEPA Q01198 c alpha-dehydrogenase (30.7% identity FT in 241 aa overlap); contains PS00061 Short-chain alcohol FT dehydrogenase family signature, PS00697 ATP-dependent DNA FT ligase AMP-binding site. N-terminus corresponds to several FT epoxide hydrolases of plants and Mycobacterium tuberculosis FT e.g. MTCY9F925" FT /db_xref="GOA:P66777" FT /db_xref="HSSP:1FDS" FT /db_xref="InterPro:IPR002347" FT /db_xref="UniProtKB/Swiss-Prot:P66777" FT /protein_id="CAA94272.1" FT /translation="MPATQQMSRLVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLW FT DGVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSPGEPVHVLA FT HDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGGLRRPWRPRTFLRAISQT FT LRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDIPVDQIHHSETLARDAAHSVKTYP FT ANYFRSFSSSRRGRAIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHF FT SPMSHPQVMAAAVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRET FT ALAFAREGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVSAEH FT GVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQRLVERGTGGHIVN FT VSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAGVGLTTICPGVIDTNIVATTGF FT HAPGTDEEKIDGRRGQIDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGIS FT RVLPQALRSTARLRVI" FT CDS 57126..58787 FT /transl_table=11 FT /gene="sucB" FT /locus_tag="Rv2215" FT /product="Probable pyruvate dehydrogenase (E2 component) FT SucB" FT /function="Involved in tricarboxylic acid cycle; converts FT 2-oxoglutarate to succinyl-CoA and CO2" FT /EC_number="2.3.1.61" FT /note="Rv2215, (MTCY190.26), len: 553 aa. Probable sucB, FT dihydrolipoamide acetyltransferase component (E2), similar FT to e.g. SW:O PD2_ACHLA P35489 dihydrolipoamide FT acetyltransferase component (E2) of pyruvate dehydrogenase FT complex (35.3% identity in 552 aa overlap); contains FT PS00189 2-oxo acid dehydrogenases acyltransferase component FT lipoyl binding site." FT /db_xref="GOA:P65633" FT /db_xref="HSSP:1C4T" FT /db_xref="InterPro:IPR004167" FT /db_xref="UniProtKB/Swiss-Prot:P65633" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94256.1" FT /translation="MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVD FT TEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAP FT EPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKV FT DTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPK FT AEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAE FT QKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATA FT QLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNED FT TKEITYYDAEHLGFAVDTEQGLLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDEL FT SGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYL FT PLTYDHRLIDGADAGRFLTTIKHRLEEGAFEADLGL" FT CDS 58787..59692 FT /transl_table=11 FT /locus_tag="Rv2216" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2216, (MTCY190.27), len: 301 aa. Conserved FT hypothetical protein, equivalent to Mycobacterium leprae FT ML0860 (307 aa), Z98741|MLCB22_10 Mycobacterium leprae FT cosmid B22; H (307 aa). FASTA score: opt: 1656, E(): 0; FT 84.2% identity in 297 aa overlap. Also FT gp|AE000319|ECAE000319_8 Escherichia coli strain K12 MG1655 FT (297 aa) opt: 640, E(): 0; 39.5% identity in 294 aa FT overlap." FT /db_xref="GOA:P67232" FT /db_xref="InterPro:IPR010099" FT /db_xref="UniProtKB/Swiss-Prot:P67232" FT /protein_id="CAA94257.1" FT /translation="MANAVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEELH FT WNPESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSAAVADAG FT VATLINASAVGYYGNTKDRVVDENDSAGTGFLAQLCVDWETATRPAQQSGARVVLARTG FT VVLSPAGGMLRRMRPLFSVGLGARLGSGRQYMSWISLEDEVRALQFAIAQPNLSGPVNL FT TGPAPVTNAEFTTAFGRAVNRPTPLMLPSVAVRAAFGEFADEGLLIGQRAIPSALERAG FT FQFHHNTIGEALGYATTRPG" FT CDS 59745..60437 FT /transl_table=11 FT /gene="lipB" FT /locus_tag="Rv2217" FT /product="Probable lipoate biosynthesis protein B LipB" FT /function="lipoate biosynthesis" FT /EC_number="6.-.-.-" FT /note="Rv2217, (MTCY190.28), len: 230 aa. Probable lipB, FT similar to SW:LIPB_ECOLI P30976 liopate biosynthesis FT protein B ( 33.8% identity in 160 aa overlap). Equivalent FT to gp|Z98741| MLCB22_11 Mycobacterium leprae (235 aa). FT FASTA score: opt: 1124, E(): 0; 78.4% identity in 218 aa FT overlap" FT /db_xref="GOA:Q10404" FT /db_xref="InterPro:IPR000544" FT /db_xref="PDB:1W66" FT /db_xref="UniProtKB/Swiss-Prot:Q10404" FT /protein_id="CAA94273.1" FT /translation="MTGSIRSKLSAIDVRQLGTVDYRTAWQLQRELADARVAGGADTLL FT LLEHPAVYTAGRRTETHERPIDGTPVVDTDRGGKITWHGPGQLVGYPIIGLAEPLDVVN FT YVRRLEESLIQVCADLGLHAGRVDGRSGVWLPGRPARKVAAIGVRVSRATTLHGFALNC FT DCDLAAFTAIVPCGISDAAVTSLSAELGRTVTVDEVRATVAAAVCAALDGVLPVGDRVP FT SHAVPSPL" FT CDS 60434..61369 FT /transl_table=11 FT /gene="lipA" FT /locus_tag="Rv2218" FT /product="Probable lipoate biosynthesis protein A LipA" FT /function="lipoate biosynthesis" FT /note="Rv2218, (MTCY190.29), len: 311 aa. Probable lipA, FT lipoic acid synthetase, similar to e.g. SW:LIPA_HAEIN FT P44463 (42 .6% identity in 291 aa overlap). Equivalent to FT Z98741|MLCB2 2_12 Mycobacterium leprae cosmid B22; (314 FT aa). FASTA score : opt: 1836, E(): 0; 86.8% identity in 310 FT aa overlap" FT /db_xref="GOA:P65283" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/Swiss-Prot:P65283" FT /protein_id="CAA94258.1" FT /translation="MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNL FT VRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDRDEPR FT RVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPDFNGEP FT TRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAGLVTKSNLILGL FT GETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFA FT GVLAGPLVRSSYRAGRLYEQARNSRALASR" FT CDS 61396..62148 FT /transl_table=11 FT /locus_tag="Rv2219" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2219, (MTCY190.30), len: 250 aa. Probable FT conserved transmembrane protein. Equivalent to hypothetical FT membrane protein ML0857 (250 aa) from Mycobacterium leprae FT Z98741 |MLCB22_13 Mycobacterium leprae cosmid B22; H (250 FT aa) opt : 1328, E(): 0; 80.8% identity in 250 aa overlap." FT /db_xref="GOA:Q10405" FT /db_xref="UniProtKB/Swiss-Prot:Q10405" FT /protein_id="CAA94259.1" FT /translation="MAKPRNAAESKAAKAQANAARKAAARQRRAQLWQAFTLQRKEDKR FT LLPYMIGAFLLIVGASVGVGVWAGGFTMFTMIPLGVLLGALVAFVIFGRRAQRTVYRKA FT EGQTGAAAWALDNLRGKWRVTPGVAATGNLDAVHRVIGRPGVIFVGEGSAARVKPLLAQ FT EKKRTARLVGDVPIYDIIVGNGDGEVPLAKLERHLTRLPANITVKQMDTVESRLAALGS FT RAGAGVMPKGPLPTTAKMRSVQRTVRRK" FT CDS complement(62155..62577) FT /transl_table=11 FT /locus_tag="Rv2219A" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2219A, len: 140 aa. Probable conserved membrane FT protein, similar to SC3H12.05c|AL355740_5 possible integral FT membrane protein from Streptomyces coelicolor (155 aa), FT FASTA scores: opt: 327, E(): 7.5e-14, (46.6% identity in FT 133 aa overlap), also linked to glnA." FT /db_xref="InterPro:IPR010432" FT /db_xref="UniProtKB/TrEMBL:Q79FG7" FT /protein_id="CAE55463.1" FT /translation="MTAKSPPDYPGKTLGLPDTGPGSLAPMGRRLAALLIDWLIAYGLA FT LLGVEFGVWSTPMLSTVVLVIWLLLGVAAVRLFGFTPGQLMLGLVVVAVGGRRPVGIGR FT LVVRGLLIGLVVPPLFTDSDGRGLHDRLTATAVVRR" FT CDS 62776..64212 FT /transl_table=11 FT /gene="glnA1" FT /locus_tag="Rv2220" FT /standard_name="glnA" FT /product="GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) FT (GS-I)" FT /function="INVOLVED IN GLUTAMINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY: ATP + L-GLUTAMATE + NH(3) = ADP + GLUTAMINE + FT ORTHOPHOSPHATE]." FT /EC_number="6.3.1.2" FT /note="Rv2220, (MTCY190.31, MTCY427.01), len: 478 aa. FT glnA1, glutamine synthetase class I (EC 6.3.1.2) (see FT Tullius et al., 2001), similar to many e.g. FT GLNA_STRCO|P15106 from Streptomyces coelicolor, FASTA FT score: (71.4% identity in 475 aa overlap); etc. Also FT similar to three other potential glutamine synthetases in FT Mycobacterium tuberculosis: Rv2222c|glnA2, Rv2860c|glnA4, FT and Rv1878|glnA3. Contains PS00180 Glutamine synthetase FT signature 1, PS00181 Glutamine synthetase putative FT ATP-binding region signature, and PS00182 Glutamine FT synthetase class-I adenylation site. BELONGS TO THE FT GLUTAMINE SYNTHETASE FAMILY." FT /db_xref="GOA:P0A590" FT /db_xref="InterPro:IPR001637" FT /db_xref="PDB:1HTO" FT /db_xref="UniProtKB/Swiss-Prot:P0A590" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94665.1" FT /translation="MTEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDKS FT VFDDGLAFDGSSIRGFQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFTLEPY FT SRDPRNIARKAENYLISTGIADTAYFGAEAEFYIFDSVSFDSRANGSFYEVDAISGWWN FT TGAATEADGSPNRGYKVRHKGGYFPVAPNDQYVDLRDKMLTNLINSGFILEKGHHEVGS FT GGQAEINYQFNSLLHAADDMQLYKYIIKNTAWQNGKTVTFMPKPLFGDNGSGMHCHQSL FT WKDGAPLMYDETGYAGLSDTARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINL FT VYSQRNRSACVRIPITGSNPKAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIKNKIEPQA FT PVDKDLYELPPEEAASIPQTPTQLSDVIDRLEADHEYLTEGGVFTNDLIETWISFKREN FT EIEPVNIRPHPYEFALYYDV" FT misc_feature 63568..63615 FT /note="PS00181 Glutamine synthetase putative ATP-binding FT region signature" FT misc_feature 63955..63993 FT /note="PS00182 Glutamine synthetase class-I adenylation FT site" FT CDS complement(64530..67514) FT /transl_table=11 FT /gene="glnE" FT /locus_tag="Rv2221c" FT /product="GLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE GLNE FT (Glutamine-synthetase adenylyltransferase)" FT /function="REGULATORY PROTEIN INVOLVED IN THE REGULATION OF FT GLUTAMINE SYNTHETASE ACTIVITY. ADENYLYLATION AND FT DEADENYLYLATION OF GLUTAMINE SYNTHETASE. POSSIBLY REGULATES FT GLNB|Rv2919c [CATALYTIC ACTIVITY: ATP + FT [L-GLUTAMATE:AMMONIA LIGASE (ADP-FORMING)] = PYROPHOSPHATE FT + ADENYLYL-[L-GLUTAMATE:AMMONIA LIGASE (ADP-FORMING)]]." FT /EC_number="2.7.7.42" FT /note="Rv2221c, (MTCY190.32c, MTCY427.02c), len: 994 aa. FT glnE, glutamate-ammonia-ligase adenylyltransferase (EC FT 2.7.7.42) (see citations below), similar to others e.g. FT GLNE_ECOLI|P30870 glutamate-ammonia-ligase FT adenylyltransferase from Escherichia coli, FASTA score: FT (24.4% identity in 721 aa overlap); GLNE_HAEIN|P44419 FT Glutamate-ammonia-ligase adenylyltransferase from FT Haemophilus influenzae (981 aa), FASTA score: (28.1% FT identity in 199 aa overlap); etc. Note that initiation FT codon uncertain." FT /db_xref="GOA:P69942" FT /db_xref="InterPro:IPR013546" FT /db_xref="UniProtKB/Swiss-Prot:P69942" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94664.1" FT /translation="MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVD FT LLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDH FT LVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAAL FT DLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGA FT RELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLES FT HIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRR FT RVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGG FT YIGREDAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRN FT DAAGVLREELKKQNVRVSKLHTKLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYE FT GPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESW FT YLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARA FT LIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQAAL FT DVMIRASLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARAVKWST FT SIAERVRALLGTPSVDPPLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLR FT AHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHTK FT LGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAADVELLRQAWLT FT ATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGEFLDNYLRVTRRAKAVVR FT KVFGS" FT CDS complement(67563..68903) FT /transl_table=11 FT /gene="glnA2" FT /locus_tag="Rv2222c" FT /product="PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE FT SYNTHASE) (GS-II)" FT /function="INVOLVED IN GLUTAMINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY: ATP + L-GLUTAMATE + NH(3) = ADP + GLUTAMINE + FT ORTHOPHOSPHATE]." FT /EC_number="6.3.1.2" FT /note="Rv2222c, (MTCY427.03c), len: 446 aa. Probable glnA2, FT glutamine synthetase class II (EC 6.3.1.2), similar to FT others. Also similar to three other potential glutamine FT synthetases in Mycobacterium tuberculosis: Rv2220|glnA1, FT Rv2860c|glnA4, and Rv1878|glnA3. BELONGS TO THE GLUTAMINE FT SYNTHETASE FAMILY." FT /db_xref="GOA:P64245" FT /db_xref="HSSP:1LGR" FT /db_xref="InterPro:IPR004809" FT /db_xref="UniProtKB/Swiss-Prot:P64245" FT /protein_id="CAA94645.1" FT /translation="MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAF FT EEGIGFDGSSIEGFARVSESDTVAHPDPSTFQVLPWATSSGHHHSARMFCDITMPDGSP FT SWADPRHVLRRQLTKAGELGFSCYVHPEIEFFLLKPGPEDGSVPVPVDNAGYFDQAVHD FT SALNFRRHAIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYVIKEVA FT LEEGARASFMPKPFGQHPGSAMHTHMSLFEGDVNAFHSADDPLQLSEVGKSFIAGILEH FT ACEISAVTNQWVNSYKRLVQGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRVEVRSP FT DSACNPYLTFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRAMGYRELPSSLDSAL FT RAMEASELVAEALGEHVFDFFLRNKRTEWANYRSHVTPYELRTYLSL" FT repeat_region 68962..68979 FT /note="18 bp inverted repeat between 3' end of MTCY427.04c FT and 5' end of MTCY427.03c" FT CDS complement(68998..70560) FT /transl_table=11 FT /locus_tag="Rv2223c" FT /product="Probable exported protease" FT /function="function unknown; thought to hydrolyze peptides FT and/or proteins." FT /EC_number="3.4.-.-" FT /note="Rv2223c, (MTCY427.04c), len: 520 aa. Probable FT exported protease (EC 3.4.-.-); has signal sequence. Very FT similar to three proteases/peptidases from Streptomyces FT spp.: L42758, L42759, L27466. FASTA score: L42758|STMSLPD FT STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032 E(): FT 0, (37.5% identity in 533 aa overlap). Also similar to FT hypothetical proteins YZZE _ECOLI|P34211 from Escherichia FT coli (25.4% identity in 406 aa overlap) and PIR:B36944 in FT ompP 3' region (27.5% identity in 218 aa overlap). Highly FT similar to Rv2224c and Rv2672 (49.3% identity in 507 aa FT overlap); contains PS00120 Lipases, serine active site" FT /db_xref="GOA:P65821" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/Swiss-Prot:P65821" FT /protein_id="CAA94646.1" FT /translation="MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPG FT APVVAPQQSWNSCREFIADTSEIRTARCATVSVPVDYDQPGGTQAKLAVIRVPATGQRF FT GALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEF FT DAYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALG FT DDQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFND FT YAADCARSPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINALYS FT PQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPAD FT PAAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVST FT THDPATPYQSGVDLARQLGAPLITFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLR FT CAP" FT misc_feature complement(69856..69885) FT /note="PS00120 Lipases, serine active site" FT CDS complement(70622..72184) FT /transl_table=11 FT /locus_tag="Rv2224c" FT /product="Probable exported protease" FT /function="function unknown; thought to hydrolyze peptides FT and/or proteins." FT /EC_number="3.4.-.-" FT /note="Rv2224c, (MTCY427.05c), len: 520 aa. Probable FT exported protease (EC 3.4.-.-); has signal sequence and FT lipoprotein motif at N-terminal end. Very similar to three FT proteases/peptidases from Streptomyces spp.: L42758, FT L42759, L27466. FASTA score: L4 2758|STMSLPD STMSLPD NID: FT g940302 - Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% FT identity in 533 aa overlap). Similar to hypothetical FT protein SW:YZZE_ECOLI P34211 (27.7% identity in 412 aa FT overlap) and highly similar to Rv2224c and Rv2672 (49.3% FT identity in 507 aa overlap); contains PS00013, Prokaryotic FT membrane lipoprotein lipid attachment site, and PS00120 FT Lipases, serine active site." FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/Swiss-Prot:P65823" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94647.1" FT /translation="MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRARMAEPK FT LGQPVEWTPCRSSNPQVKIPGGALCGKLAVPVDYDRPDGDVAALALIRFPATGDKIGSL FT VINPGGPGESGIEAALGVFQTLPKRVHERFDLVGFDPRGVASSRPAIWCNSDADNDRLR FT AEPQVDYSREGVAHIENETKQFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALGDDKL FT TYLGYSYGTRIGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAAD FT CAKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSDAIVGTIMA FT LYSPNLWQHLTDGLSELVDNRGDTLLALADMYMRRDSHGRYNNSGDARVAINCVDQPPV FT TDRDKVIDEDRRAREIAPFMSYGKFTGDAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVV FT STTHDPATPYKAGVDLANQLRGSLLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSG FT AKC" FT misc_feature complement(71492..71521) FT /note="PS00120 Lipases, serine active site" FT CDS 72903..73748 FT /transl_table=11 FT /gene="panB" FT /locus_tag="Rv2225" FT /product="Probable 3-methyl-2-oxobutanoate FT hydroxymethyltransferase PanB" FT /function="INVOLVED IN PANTOTHENATE BIOSYNTHESIS." FT /EC_number="2.1.2.11" FT /note="Rv2225, (MTCY427.06), len: 281 aa. Probable panB, FT 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC FT 2.1.2.11), similar to PANB_ECOLI|P31057 FT 3-methyl-2-oxobutanoate hydroxymethyltransferase from FT Escherichia coli (45.9% identity in 257 aa overlap)." FT /db_xref="GOA:P0A5Q8" FT /db_xref="InterPro:IPR015813" FT /db_xref="PDB:1OY0" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Q8" FT /protein_id="CAA94648.1" FT /translation="MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYS FT TARIFDEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPF FT GSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSV FT NTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGA FT GPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF FT " FT CDS 73993..75534 FT /transl_table=11 FT /locus_tag="Rv2226" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2226, (MTCY427.07), len: 513 aa. Conserved FT hypothetical protein, similar to hypothetical secreted FT protein (510 aa) from Streptomyces coelicolor A3(2) FT emb|CAB59601.1| (AL132662) hypothetical secreted protein FT [Streptomyces coelicolor. Smith-Waterman scores Expect = FT 5e-44 Identities = 166/506 (32%)" FT /db_xref="GOA:Q10510" FT /db_xref="InterPro:IPR007899" FT /db_xref="UniProtKB/Swiss-Prot:Q10510" FT /protein_id="CAA94649.1" FT /translation="MPVEAPRPARHLEVERKFDVIESTVSPSFEGIAAVVRVEQSPTQQ FT LDAVYFDTPSHDLARNQITLRRRTGGADAGWHLKLPAGPDKRTEMRAPLSASGDAVPAE FT LLDVVLAIVRDQPVQPVARISTHRESQILYGAGGDALAEFCNDDVTAWSAGAFHAAGAA FT DNGPAEQQWREWELELVTTDGTADTKLLDRLANRLLDAGAAPAGHGSKLARVLGATSPG FT ELPNGPQPPADPVHRAVSEQVEQLLLWDRAVRADAYDAVHQMRVTTRKIRSLLTDSQES FT FGLKESAWVIDELRELADVLGVARDAEVLGDRYQRELDALAPELVRGRVRERLVDGARR FT RYQTGLRRSLIALRSQRYFRLLDALDALVSERAHATSGEESAPVTIDAAYRRVRKAAKA FT AKTAGDQAGDHHRDEALHLIRKRAKRLRYTAAATGADNVSQEAKVIQTLLGDHQDSVVS FT REHLIQQAIAANTAGEDTFTYGLLYQQEADLAERCREQLEAALRKLDKAVRKARD" FT misc_RNA complement(75606..75912) FT /gene="rnpB" FT /product="ribonuclease P RNA" FT /function="RNA COMPONENT OF RNase P: RNase P CATALYZES THE FT REMOVAL OF THE 5'-LEADER SEQUENCE FROM PRE-tRNA TO PRODUCE FT THE MATURE 5'TERMINUS. THIS PROTEIN PLAYS AN AUXILIARY BUT FT ESSENTIAL ROLE IN VIVO BY BINDING TO THE 5'-LEADER SEQUENCE FT AND BROADENING THE SUBSTRATE SPECIFICITY OF THE RIBOZYME." FT /note="rnpB, len: 307 nt. rna component of RNase P." FT CDS 76092..76793 FT /transl_table=11 FT /locus_tag="Rv2227" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2227, (MTCY427.08), len: 233 aa. Conserved FT hypothetical protein, similar to conserved hypothetical FT proteins from various bacteria e.g. gb|AAK22693.1| FT (AE005746) conserved hypothetical protein from Caulobacter FT crescentus (234 aa) Smith-Waterman score = 109 bits (429), FT Expect = 1e-41 Identities = 83/167 (49%)" FT /db_xref="InterPro:IPR018655" FT /db_xref="UniProtKB/Swiss-Prot:Q10511" FT /protein_id="CAA94650.1" FT /translation="MGQTRRLRRLGRHRCRGQRVRWRTATSADHPRRGRPAAQAVRRRR FT PVSLDGRYGIQAVRRRAVSIFPCPLSRVIERLKQALYPKLLPIARNWWAKLGREAPWPD FT SLDDWLASCHAAGQTRSTALMLKYGTNDWNALHQDLYGELVFPLQVVINLSDPETDYTG FT GEFLLVEQRPRAQSRGTAMQLPQGHGYVFTTRDRPVRTSRGWSASPVRHGLSTIRSGER FT YAMGLIFHDAA" FT CDS complement(76805..77899) FT /transl_table=11 FT /locus_tag="Rv2228c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2228c, (MTCY427.09c), len: 364 aa. Conserved FT hypothetical protein. Some similarity to phosphoglycerate FT mutase and ribonuclease H. Similar to CAB88177.1|AL352972 FT putative bifunctional protein (ribonuclease FT H/phosphoglycerate mutase) from Streptomyces coelicolor FT A3(2) (497 aa); Smith-Waterman scores: 107 bits (424), FT Expect = 4e-41 Identities = 160/485 (32%). Also similar in FT C-terminal part to Rv2419c and Rv2135c." FT /db_xref="GOA:P64955" FT /db_xref="HSSP:1RBS" FT /db_xref="InterPro:IPR014636" FT /db_xref="UniProtKB/Swiss-Prot:P64955" FT /protein_id="CAA94651.1" FT /translation="MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATN FT NVAEYRGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQALAS FT QFRRINYEWVPRARNTYADRLANDAMDAAAQSAAADADPAKIVATESPTSPGWTGARGT FT PTRLLLLRHGQTELSEQRRYSGRGNPGLNEVGWRQVGAAAGYLARRGGIAAVVSSPLQR FT AYDTAVTAARALALDVVVDDDLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPG FT GESFDDVLRRVRRGRDRIIVGYEGATVLVVSHVTPIKMLLRLALDAGSGVLYRLHLDLA FT SLSIAEFYADGASSVRLVNQTGYL" FT CDS complement(77896..78633) FT /transl_table=11 FT /locus_tag="Rv2229c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2229c, (MTCY427.10c), len: 245 aa. Conserved FT hypothetical protein; probable coiled-coil protein similar FT to conserved hypothetical proteins in Actinomycetes. FT Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA FT scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa FT overlap emb|CAC30589.1| (AL583922)" FT /db_xref="HSSP:1NLW" FT /db_xref="InterPro:IPR003743" FT /db_xref="UniProtKB/Swiss-Prot:Q10513" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94652.1" FT /translation="MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEHN FT AANDRMAALRIAAEDLDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHELD FT SLQRRQASLEDALLEVLERREELQAQQTAESRALQALRADLAAAQQALDEALAEIDQAR FT HQHSSQRDMLTATLDPELAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQISAA FT AEDEVVRCPECGAILLRLEGFEE" FT CDS complement(78630..79769) FT /transl_table=11 FT /locus_tag="Rv2230c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2230c, (MTCY427.11c), len: 379 aa. Conserved FT hypothetical protein. Equivalent to Mycobacterium leprae, FT ML1639, conserved hypothetical protein (385 aa). Similar to FT hypothetical proteins from B. subtilis, P54472, and L. FT monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) FT opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap FT same as >pir||T44719 hypothetical protein MLCB1243.36 FT [imported] - Mycobacterium leprae FT >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU FT HYPOTHETICAL 30. 7 kDa PROTEIN IN (279 aa) opt: 604; E(): FT 2.2e-30; 38.8% identity in 258 aa overlap. FT P53434|YRP2_LISMO HYPOTHETICAL 41.4 kDa PROTEIN (373 aa) FT opt: 595, E(): 1e-29; 30.7% identity in 326 aa overlap" FT /db_xref="InterPro:IPR017221" FT /db_xref="UniProtKB/Swiss-Prot:P0A656" FT /protein_id="CAA94653.1" FT /translation="MSVRLADVIDVLDQAYPPRLAQSWDSVGLVCGDPDDVVDSVTVAV FT DATPAVVDQVPQAGLLLVHHPLLLRGVDTVAANTPKGVLVHRLIRTGRSLFTAHTNADS FT ASPGVSDALAHAVGLTVDAVLDPVPGAADLDKWVIYVPRENSEAVRAAVFEAGAGHIGD FT YSHCSWSVAGTGQFLAHDGASPAIGSVGTVERVAEDRVEVVAPARARAEVLAAMRAAHP FT YEEPAFDIFALVPPPVGSGLGRIGRLPKPEPLRTFVARLEAALPPTATGVRAAGDPDLL FT VSRVAVCGGAGDSLLATVAAADVQAYVTADLRHHPADEHCRASQVALIDVAHWASEFPW FT CGQAAEVLRSHFGASLPVRVCTICTDPWNLDHETGRDQA" FT CDS complement(79766..80860) FT /transl_table=11 FT /gene="cobC" FT /locus_tag="Rv2231c" FT /product="Possible aminotransferase CobC" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS" FT /note="Rv2231c, (MTCY427.12c), len: 364 aa. Possible cobC, FT aminotransferase. Note that initiation codon uncertain. FT Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE FT COBC PROTEIN (333 aa) opt: 277, E(): 1.7e-11; 28.8% FT identity in 313 aa overlap and also to e.g. SW:HIS8_ECOLI FT P06986 histidinol-phosphate aminotransferase (27.0% FT identity in 289 aa overlap), contains PS00105 FT aminotransferases class-I pyridoxal-phosphate attachment FT site. Real Mycobacterium tuberculosis histidinol-phosphate FT aminotransferase, hisC, is Rv1600 (MTCY336.04c)." FT /db_xref="GOA:P63500" FT /db_xref="HSSP:1LC7" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P63500" FT /protein_id="CAA94654.1" FT /translation="MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAV FT NVRHDRPPEWLVRQLAALLPELARYPSTDDVHRAQDAVAERHGRTRDEVLPLVGAAEGF FT ALLHNLSPVRAAIVVPAFTEPAIALSAAGITAHHVVLKPPFVLDTAHVPDDADLVVVGN FT PTNPTSVLHLREQLLELRRPGRILVVDEAFADWVPGEPQSLADDSLPDVLVLRSLTKTW FT SLAGLRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTAL FT RAEMVAGLRSVGAEVVDGAAPFVLFNIADADGLRNYLQSKGIAVRRGDTFVGLDARYLR FT AAVRPEWPVLVAAIAEWAKRGGRR" FT misc_feature complement(80171..80212) FT /note="PS00105 Aminotransferases class-I FT pyridoxal-phosphate attachment site" FT CDS 81439..82314 FT /transl_table=11 FT /locus_tag="Rv2232" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2232, (MTCY427.13), len: 291 aa. Conserved FT hypothetical protein, similar to members of haloacid FT dehalogenase-like family from several bacteria and to FT putative phosphatases e.g. Q9I767 and AAK78398. Contains FT N-terminal extension. FASTA scores: Q9I767 HYPOTHETICAL FT PROTEIN PA0065 (221 aa) opt: 439 E(): 3.2e-18; 38.679% FT identity (40.196% ungapped) in 212 aa overlap; FT >>tr|AAK78398 Predicted phosphatase, HAD family (216 aa) FT opt: 427, E(): 1.5e-17; 34.762% identity (35.437% ungapped) FT in 210 aa overlap. Replaces previous Rv2232 and Rv2233." FT /db_xref="GOA:P68911" FT /db_xref="InterPro:IPR006439" FT /db_xref="UniProtKB/Swiss-Prot:P68911" FT /protein_id="CAA94666.2" FT /translation="MSSPRERRPASQAPRLSRRPPAHQTSRSSPDTTAPTGSGLSNRFV FT NDNGIVTDTTASGTNCPPPPRAAARRASSPGESPQLVIFDLDGTLTDSARGIVSSFRHA FT LNHIGAPVPEGDLATHIVGPPMHETLRAMGLGESAEEAIVAYRADYSARGWAMNSLFDG FT IGPLLADLRTAGVRLAVATSKAEPTARRILRHFGIEQHFEVIAGASTDGSRGSKVDVLA FT HALAQLRPLPERLVMVGDRSHDVDGAAAHGIDTVVVGWGYGRADFIDKTSTTVVTHAAT FT IDELREALGV" FT CDS 82307..82798 FT /transl_table=11 FT /gene="ptpA" FT /locus_tag="Rv2234" FT /standard_name="MPtpA" FT /product="PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPA FT (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) (LMW PHOSPHATASE)" FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT DEPHOSPHORYLATION). CAN DEPHOSPHORYLATED IN VITRO THE FT PHOSPHOTYROSINE RESIDUE OF MYELIN BASIC PROTEIN (MBP) AT pH FT 7.0 [CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O FT = protein tyrosine + phosphate]." FT /EC_number="3.1.3.48" FT /note="Rv2234, (MTCY427.15), len: 163 aa. ptpA (alternate FT gene name: MPtpA), low molecular weight FT protein-tyrosine-phosphatase (see citations below) (EC FT 3.1.3.48), similar to other phosphotyrosine protein FT phosphatases e.g. P53433|PTPA_STRCO LOW MOLECULAR WEIGHT FT PROTEIN-TYROSINE PHOSPHATASE from Streptomyces coelicolor FT (164 aa), FASTA scores: opt: 455, E(): 3.3e -25, (49.7% FT identity in 155 aa overlap); PA1S_HUMAN|P24667 red cell FT acid phosphatase 1, FASTA score: (37.7% identity in 138 aa FT overlap); etc. Contains a phosphatase catalytic site domain FT located in N-terminal part. Activity proven biochemically. FT Supposed a secreted protein." FT /db_xref="GOA:P65716" FT /db_xref="InterPro:IPR017867" FT /db_xref="PDB:1U2Q" FT /db_xref="UniProtKB/Swiss-Prot:P65716" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94656.1" FT /translation="MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGT FT GNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEA FT ARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS FT " FT CDS 82798..83613 FT /transl_table=11 FT /locus_tag="Rv2235" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN: MAY BE INVOLVED IN THE ABILITY TO FT SURVIVE IN MACROPHAGES." FT /note="Rv2235, (MTCY427.16), len: 271 aa. Probable FT conserved transmembrane protein (see Miller & Shinnick FT 2001); hydrophobic regions near N- and C-terminus. Similar FT to conserved membrane proteins in other Actinomycetes. FT Equivalent to Mycobacterium leprae. ML1644 (270 aa). FASTA FT scores: opt: 1357, E(): 1.2e-72; 74.170% identity in 271 aa FT overlap T44717|3150235|CAA19213.1|AL023635 FT 13093419|CAC30595.1|AL583922." FT /db_xref="GOA:P66883" FT /db_xref="InterPro:IPR002994" FT /db_xref="UniProtKB/Swiss-Prot:P66883" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94657.1" FT /translation="MPRLAFLLRPGWLALALVVVAFTYLCFTVLAPWQLGKNAKTSREN FT QQIRYSLDTPPVPLKTLLPQQDSSAPDAQWRRVTATGQYLPDVQVLARLRVVEGDQAFE FT VLAPFVVDGGPTVLVDRGYVRPQVGSHVPPIPRLPVQTVTITARLRDSEPSVAGKDPFV FT RDGFQQVYSINTGQVAALTGVQLAGSYLQLIEDQPGGLGVLGVPHLDPGPFLSYGIQWI FT SFGILAPIGLGYFAYAEIRARRREKAGSPPPDKPMTVEQKLADRYGRRR" FT CDS complement(83595..84536) FT /transl_table=11 FT /gene="cobD" FT /locus_tag="Rv2236c" FT /product="Probable cobalamin biosynthesis transmembrane FT protein CobD" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS, IN THE FT CONVERSION OF COBYRIC ACID TO COBINAMIDE." FT /note="Rv2236c, (MTCY427.17c), len: 313 aa. Probable cobD, FT cobalamin biosynthesis transmembrane protein, similar to FT S52223 Rhodobacter capsulatus 945 protein BluD (39.0% FT identity in 287 aa overlap) involved in cobinamide FT synthesis, and to COBD_PSEDE Pseudomonas dentrificans cobD FT protein (37.5% identity in 269 aa overlap), also CBIB_SALTY FT Salmonella typhimurum cbiB protein (35.5% identity in 304 FT aa overlap)." FT /db_xref="GOA:Q10518" FT /db_xref="InterPro:IPR004485" FT /db_xref="UniProtKB/Swiss-Prot:Q10518" FT /protein_id="CAA94658.1" FT /translation="MFASTWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQI FT TYRDGRVAGAVHVGLLVGAVGLLGAALQRLPGRSWPVAATATATWAALGGTSLARTGRQ FT ISDLLERDDVEAARRLLPSLCGRDPAQLGGPGLTRAALESVAENTADAQVVPLLWAASS FT GVPAVLGYRAINTLDSMIGYRSPRYLRFGWAAARLDDWANYVGARATAVLVVICAPVVG FT GSPRGAVRAWRRDAARHPSPNAGVVEAAFAGALDVRLGGPTRYHHELQIRPTLGDGRSP FT KVADLRRAVVLSRVVQAGAAVLAVMLVYRRRP" FT CDS 84650..85417 FT /transl_table=11 FT /locus_tag="Rv2237" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2237, (MTCY427.18), len: 255 aa. Conserved FT hypothetical protein. Similar to Mycobacterium tuberculosis FT hypothetical proteins Rv0276, Rv0826, Rv1645c. FASTA score: FT Rv0276 gp|AL021930|MTV035_4 (306 aa) opt: 874, E(): 0; FT 49.6% identity in 282 aa overlap" FT /db_xref="GOA:P64957" FT /db_xref="InterPro:IPR018713" FT /db_xref="UniProtKB/Swiss-Prot:P64957" FT /protein_id="CAA94667.1" FT /translation="MLLPAANVIMQLAVPGVGYGVLESPVDSGNVYKHPFKRARTTGTY FT LAVATIGTESDRALIRGAVDVAHRQVRSTASSPVSYNAFDPKLQLWVAACLYRYFVDQH FT EFLYGPLEDATADAVYQDAKRLGTTLQVPEGMWPPDRVAFDEYWKRSLDGLQIDAPVRE FT HLRGVASVAFLPWPLRAVAGPFNLFATTGFLAPEFRAMMQLEWSQAQQRRFEWLLSVLR FT LADRLIPHRAWIFVYQLYLWDMRFRARHGRRIV" FT tRNA complement(85759..85830) FT /gene="tRNA-Val(TAC)" FT /product="transfer RNA-Val(TAC)" FT /anticodon=(pos:85796..85798,aa:Val) FT CDS complement(85876..86337) FT /transl_table=11 FT /gene="ahpE" FT /locus_tag="Rv2238c" FT /product="Probable peroxiredoxin AhpE" FT /function="detoxification of organic peroxides." FT /note="Rv2238c, (MTCY427.19c), len: 153 aa. Probable ahpE, FT peroxiredoxin. Similarity to many members of AHPC/TSA FT family e.g. sp|Q96291|BAS1_ARATH 2-CYS PEROXIREDOXIN BAS1 FT PRECURSOR (265 aa). FASTA score: opt: 275, E(): 2.7e-12; FT 35.0% identity in 143 aa overlap." FT /db_xref="GOA:P65688" FT /db_xref="InterPro:IPR012335" FT /db_xref="PDB:1XVW" FT /db_xref="UniProtKB/Swiss-Prot:P65688" FT /protein_id="CAA94659.1" FT /translation="MLNVGATAPDFTLRDQNQQLVTLRGYRGAKNVLLVFFPLAFTGIC FT QGELDQLRDHLPEFENDDSAALAISVGPPPTHKIWATQSGFTFPLLSDFWPHGAVSQAY FT GVFNEQAGIANRGTFVVDRSGIIRFAEMKQPGEVRDQRLWTDALAALTA" FT CDS complement(86337..86813) FT /transl_table=11 FT /locus_tag="Rv2239c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2239c, (MTCY427.20c), len: 158 aa. Conserved FT hypothetical protein, similar to conserved hypothetical FT proteins from Mycobacterium leprae (ML1649, 140 aa) and FT Streptomyces coelicolor A3(2) (SCC8A.28c, 159 aa). FT Equivalent to ML1649 conserved hypothetical protein (140 FT aa). FASTA scores: ML1649 conserved hypothetical protein FT (140 aa) opt: 846, E(): 6.5e-45; 86.429% identity in 140 aa FT overlap (tr|O69479|O69479 HYPOTHETICAL 15.2 KDA PROTEIN FT (140 aa); and opt: 447, E(): 1.2e-21; 50.355% identity FT (51.825% ungapped) in 141 aa overlap. Similarity with FT ML1649 suggests alternative start at 251198." FT /db_xref="UniProtKB/Swiss-Prot:P64959" FT /protein_id="CAA94660.1" FT /translation="MPIATVCTWPAETEGGSTVVAADHASNYARKLGIQRDQLIQEWGW FT DEDTDDDIRAAIEEACGGELLDEDTDEVIDVVLLWWRDGDGDLVDTLMDAIGPLAEDGV FT IWVVTPKTGQPGHVLPAEIAEAAPTAGLMPTSSVNLGNWSASRLVQPKSRAGKR" FT CDS complement(86851..87648) FT /transl_table=11 FT /locus_tag="Rv2240c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2240c, (MTCY427.21c), len: 265 aa. Hypothetical FT unknown protein." FT /db_xref="GOA:Q10522" FT /db_xref="UniProtKB/Swiss-Prot:Q10522" FT /protein_id="CAA94661.1" FT /translation="MGQIVAGEIGGQRTTPVGGGLPLACCLDGRPPIVPHRRRRRIAAL FT RSVLRMRDTPRPARSRCDQVTSHAVLIGWRAVPRRHGGELPRRGALALGCIALLLMGIV FT GCTTVTDGTAMPDTNVAPAYRSSVSASVSASAATSSIRESQRQQSLTTKAIRTSCDALA FT ATSKDAIDKVNAYVAAFNQGRNTGPTEGPAIDALNNSASTVSGSLSAALSAQLGDALNA FT YVDAARAVANAIGAHASTAEFNRRVDRLNDTKTKALTMCVAAF" FT CDS 87700..90405 FT /transl_table=11 FT /gene="aceE" FT /locus_tag="Rv2241" FT /product="Probable pyruvate dehydrogenase E1 component aceE FT (PYRUVATE DECARBOXYLASE) (PYRUVATE DEHYDROGENASE) (PYRUVIC FT DEHYDROGENASE)" FT /function="Involved in energy metabolism; contributes to FT acetyl-CoA production as part of pyruvate dehydrogenase FT complex [CATALYTIC ACTIVITY: PYRUVATE + LIPOAMIDE = FT S-ACETYL-DIHYDRO-LIPOAMIDE + CO(2)]." FT /EC_number="1.2.4.1" FT /note="Rv2241, (MTCY427.22), len: 901 aa. Probable aceE, FT pyruvate dehydrogenase E1 component (EC 1.2.4.1), similar FT to others e.g. ODP1_ECOLI|P06958 pyruvate dehydrogenase E1 FT component from Escherichia coli, FASTA score: (51.2% FT identity in 891 aa overlap); etc." FT /db_xref="GOA:Q10504" FT /db_xref="HSSP:1L8A" FT /db_xref="InterPro:IPR015941" FT /db_xref="UniProtKB/Swiss-Prot:Q10504" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94662.1" FT /translation="MASYLPDIDPEETSEWLESFDTLLQRCGPSRARYLMLRLLERAGE FT QRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGG FT HISTYASSAALYEVGFNHFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQLDG FT FRQEHSHVGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTSD FT QHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRGNGKIIQELES FT FFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGGYVRDHFFG FT RDPRTKALVENMSDQDIWNLKRGGHDYRKVYAAYRAAVDHKGQPTVILAKTIKGYALGK FT HFEGRNATHQMKKLTLEDLKEFRDTQRIPVSDAQLEENPYLPPYYHPGLNAPEIRYMLD FT RRRALGGFVPERRTKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVLRDKQIG FT PRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDADLMLAYKESEVGQILHEGINE FT AGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGATAGR FT TTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMCGENPENIFFYI FT TVYNEPYVQPPEPENFDPEGVLRGIYRYHAATEQRTNKAQILASGVAMPAALRAAQMLA FT AEWDVAADVWSVTSWGELNRDGVAIETEKLRHPDRPAGVPYVTRALENARGPVIAVSDW FT MRAVPEQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALAGDGEID FT PSVPVAAARQYRIDDVAAAPEQTTDPGPGA" FT CDS 90465..91709 FT /transl_table=11 FT /locus_tag="Rv2242" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2242, (MTCY427.23), len: 414 aa. Conserved FT hypothetical protein. Equivalent to ML1652 conserved FT hypothetical protein from Mycobacterium leprae (414 aa), FT and orthologue in Streptomyces coelicolor A3(2). FASTA FT scores: ML1652 opt: 2369, E(): 4.2e-128; 88.406% identity FT in 414 aa overlap (AL023635)(AL583922). some similarity at FT 3' end with S25203 srmR protein - Streptomyces ambofaciens FT (604 aa) opt: 188 E(): 9e-05; (26.4% identity in 277 aa FT overlap) and with SW:YAEG_HAEIN P44509 hypothetical protein FT HI0093 (42.3% identity in 52 aa overlap). Contains possible FT helix-turn-helix motif at aa 360-381 (+3.52 SD)" FT /db_xref="UniProtKB/Swiss-Prot:P63749" FT /protein_id="CAA94663.1" FT /translation="MNDNQLAPVARPRSPLELLDTVPDSLLRRLKQYSGRLATEAVSAM FT QERLPFFADLEASQRASVALVVQTAVVNFVEWMHDPHSDVGYTAQAFELVPQDLTRRIA FT LRQTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEARG FT TWDSRMEASVVDAVVRGDTGPELLSRAAALNWDTTAPATVLVGTPAPGPNGSNSDGDSE FT RASQDVRDTAARHGRAALTDVHGTWLVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTA FT PMLTAAHRSASEAISGMNAVAGWRGAPRPVLARELLPERALMGDASAIVALHTDVMRPL FT ADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVL FT RVAATVGQLNYPTPH" FT CDS 91948..92856 FT /transl_table=11 FT /gene="fabD" FT /locus_tag="Rv2243" FT /standard_name="mtFabD" FT /product="MALONYL CoA-ACYL CARRIER PROTEIN TRANSACYLASE FT FABD (Malonyl CoA:AcpM acyltransferase) (MCT)" FT /function="CATALYZES MALONYL-COA-ACP TRANSACYLASE (MCAT) FT ACTIVITY USING HOLO-ACPM AS SUBSTRATE FOR TRANSACYLATION FT [CATALYTIC ACTIVITY: MALONYL-CoA + [ACYL-CARRIER PROTEIN] = FT CoA + MALONYL-[ACYL-CARRIER PROTEIN]]." FT /EC_number="2.3.1.39" FT /note="Rv2243, (MTCY427.24), len: 302 aa. fabD (alternate FT gene name: mtFabD), malonyl CoA-acyl carrier protein FT transacylase (EC 2.3.1.39) (see citations below), highly FT similar to e.g. A57356 acyl-CoA carrier protein FT malonyltransferase from Streptomyces coelicolor (316 aa), FT FASTA score: opt: 955, E(): 0, (52.6% identity in 304 aa FT overlap); FABD_HAEIN|P43712 malonyl CoA-acyl carrier FT protein transacylase from Haemophilus influenzae, FASTA FT score: (30.5% identity in 308 aa overlap); and FT FABD_ECOLI|P25715 from Escherichia coli, FASTA score: FT (31.4% identity in 309 aa overlap)." FT /db_xref="GOA:P63458" FT /db_xref="InterPro:IPR001227" FT /db_xref="PDB:2QC3" FT /db_xref="UniProtKB/Swiss-Prot:P63458" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94639.1" FT /translation="MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLG FT TTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAGKDVIVAGHSVGEIAAYAIAGVI FT AADDAVALAATRGAEMAKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAGQIV FT AAGRLTALEKLAEDPPAKARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPTATLL FT SNRDGKPVTSAAAAMDTLVSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKRE FT LRGVPARAVKSPADLDELANL" FT CDS 92932..93279 FT /transl_table=11 FT /gene="acpM" FT /locus_tag="Rv2244" FT /product="MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN ACPM" FT /function="INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC FT ACIDS SYNTHESIS); INVOLVED IN MEROMYCOLATE EXTENSION." FT /note="Rv2244, (MT2304, MTCY427.25), len: 115 aa. acpM, FT acyl carrier protein, meromycolate precursor transport, FT involved in meromycolate extension (see citations below). FT Highly similar to others e.g. FT L43074|STMFABD2|STMFABD|g870805 acyl carrier protein from FT Streptomyces glaucescens (82 aa), FASTA scores: opt: 298, FT E(): 8.4e-13, (56.6% identity in 76 aa overlap); and FT ACP_ECOLI|P02901 acyl carrier protein from Escherichia FT coli, FASTA score: (37.3% identity in 67 aa overlap); etc." FT /db_xref="GOA:P0A4W6" FT /db_xref="InterPro:IPR006162" FT /db_xref="PDB:1KLP" FT /db_xref="UniProtKB/Swiss-Prot:P0A4W6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94640.1" FT /translation="MPVTQEEIIAGIAEIIEEVTGIEPSEITPEKSFVDDLDIDSLSMV FT EIAVQTEDKYGVKIPDEDLAGLRTVGDVVAYIQKLEEENPEAAQALRAKIESENPDAVA FT NVQARLEAESK" FT CDS 93276..94526 FT /transl_table=11 FT /gene="kasA" FT /locus_tag="Rv2245" FT /product="3-OXOACYL-[ACYL-CARRIER PROTEIN] SYNTHASE 1 KASA FT (BETA-KETOACYL-ACP SYNTHASE) (KAS I)" FT /function="INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC FT ACIDS SYNTHESIS); INVOLVED IN MEROMYCOLATE EXTENSION. FT CATALYZES THE CONDENSATION REACTION OF FATTY ACID SYNTHESIS FT BY THE ADDITION TO AN ACYL ACCEPTOR OF TWO CARBONS FROM FT MALONYL-ACP [CATALYTIC ACTIVITY: ACYL-[ACYL-CARRIER FT PROTEIN] + MALONYL-[ACYL-CARRIER PROTEIN] = FT 3-OXOACYL-[ACYL-CARRIER PROTEIN] + [ACYL-CARRIER PROTEIN] + FT CO(2)]." FT /EC_number="2.3.1.41" FT /note="Rv2245, (MTCY427.26), len: 416 aa. kasA, FT beta-ketoacyl-ACP synthase (EC 2.3.1.41), involved in FT meromycolate extension (see citations below): belongs to FT the FAS-II system, which utilizes primarily palmitoyl-ACP FT rather than short-chain acyl-ACP primers. Highly similar to FT others e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP FT synthase from Streptomyces glaucescens (423 aa), FASTA FT scores: opt: 1105, E(): 0, (44.6% identity in 417 aa FT overlap); FABF_ECOLI|P39435 FT 3-oxoacyl-[acyl-carrier-protein] synthase II from FT Escherichia coli, FASTA score: (39.4% identity in 254 aa FT overlap); FABB_HORVU|P23902 FT 3-oxoacyl-[acyl-carrier-protein] synthase I, FASTA score: FT (33.4% identity in 413 aa overlap); etc. Strongest FT similarity to downstream ORF kasB|Rv2246|MTCY427.27 FT 3-oxoacyl-[acyl-carrier-protein] synthase 2 from FT Mycobacterium tuberculosis (438 aa), FASTA score: (66.3% FT identity in 409 aa overlap). BELONGS TO THE FT BETA-KETOACYL-ACP SYNTHASES FAMILY." FT /db_xref="GOA:P63454" FT /db_xref="HSSP:1KAS" FT /db_xref="InterPro:IPR016038" FT /db_xref="UniProtKB/Swiss-Prot:P63454" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94641.1" FT /translation="MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHA FT LEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVD FT PDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAG FT VMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDE FT PERASRPFDKDRDGFVFGEAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPA FT ADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPK FT SALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVN FT NSFGFGGHNVALAFGRY" FT CDS 94557..95873 FT /transl_table=11 FT /gene="kasB" FT /locus_tag="Rv2246" FT /product="3-OXOACYL-[ACYL-CARRIER PROTEIN] SYNTHASE 2 KASB FT (BETA-KETOACYL-ACP SYNTHASE) (KAS I)" FT /function="INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC FT ACIDS SYNTHESIS); INVOLVED IN MEROMYCOLATE EXTENSION. FT CATALYZES THE CONDENSATION REACTION OF FATTY ACID SYNTHESIS FT BY THE ADDITION TO AN ACYL ACCEPTOR OF TWO CARBONS FROM FT MALONYL-ACP [CATALYTIC ACTIVITY: ACYL-[ACYL-CARRIER FT PROTEIN] + MALONYL-[ACYL-CARRIER PROTEIN] = FT 3-OXOACYL-[ACYL-CARRIER PROTEIN] + [ACYL-CARRIER PROTEIN] + FT CO(2)]." FT /EC_number="2.3.1.41" FT /note="Rv2246, (MTCY427.27), len: 438 aa. kasB, FT beta-ketoacyl-ACP synthase (EC 2.3.1.41), involved in FT meromycolate extension (see citations below). Highly FT similar or similar to others e.g. L43074|STMFABD3|g870805 FT beta-ketoacyl-ACP synthase from Streptomyces glaucescens FT (423 aa), FASTA scores: opt: 1091, E(): 0, (44.7% identity FT in 416 aa overlap); FABF_ECOLI|P39435 FT 3-oxoacyl-[acyl-carrier-protein] synthase II from FT Escherichia coli, FASTA score: (37.0% identity in 411 aa FT overlap); FABB_HORVU|P23902 FT 3-oxoacyl-[acyl-carrier-protein] synthase I, FASTA score: FT (32.5% identity in 415 aa overlap); etc. Strongest FT similarity to upstream ORF Rv2245|kasA|MTCY427.26 FT 3-oxoacyl-[acyl-carrier-protein] synthase 1 from FT Mycobacterium tuberculosis (416 aa), FASTA score: (66.3% FT identity in 409 aa overlap). BELONGS TO THE FT BETA-KETOACYL-ACP SYNTHASES FAMILY." FT /db_xref="GOA:P63456" FT /db_xref="InterPro:IPR018201" FT /db_xref="PDB:2GP6" FT /db_xref="UniProtKB/Swiss-Prot:P63456" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94642.1" FT /translation="MGVPPLAGASRTDMEGTFARPMTELVTGKAFPYVVVTGIAMTTAL FT ATDAETTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHLLEEFDHQLTRIELRRMGYLQ FT RMSTVLSRRLWENAGSPEVDTNRLMVSIGTGLGSAEELVFSYDDMRARGMKAVSPLTVQ FT KYMPNGAAAAVGLERHAKAGVMTPVSACASGAEAIARAWQQIVLGEADAAICGGVETRI FT EAVPIAGFAQMRIVMSTNNDDPAGACRPFDRDRDGFVFGEGGALLLIETEEHAKARGAN FT ILARIMGASITSDGFHMVAPDPNGERAGHAITRAIQLAGLAPGDIDHVNAHATGTQVGD FT LAEGRAINNALGGNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLVNLD FT PEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAIAFGRY" FT CDS 95904..97325 FT /transl_table=11 FT /gene="accD6" FT /locus_tag="Rv2247" FT /product="ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) FT ACCD6" FT /function="INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC FT ACIDS SYNTHESIS) [CATALYTIC ACTIVITY: ATP + PROPIONYL-COA + FT CO(2) + H(2)O = ADP + ORTHOPHOSPHATE + METHYLMALONYL-COA]." FT /EC_number="6.4.1.3" FT /note="Rv2247, (MTCY427.28), len: 473 aa. accD6, FT Acetyl/Propionyl CoA Carboxylase, beta subunit (EC 6.4.1.3) FT (see citations below), highly similar to e.g. FT PCCB_RHOSO|Q06101 propionyl-CoA carboxylase beta chain, FT FASTA score: (75.1% identity in 437 aa overlap). Similar to FT many other Acetyl/Propionyl CoA Carboxylases from FT Mycobacterium tuberculosis. BELONGS TO THE ACCD / PCCB FT FAMILY." FT /db_xref="GOA:P63407" FT /db_xref="InterPro:IPR011762" FT /db_xref="UniProtKB/Swiss-Prot:P63407" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA94668.1" FT /translation="MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAA FT AGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEG FT VRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPD FT VVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSK FT AEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTV FT GVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRR FT GAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVG FT ILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEAL FT AQAPARRGRHKNIPL" FT repeat_region 97334..97391 FT /note="58 bp inverted repeat near 3'end of MTCY427.28" FT CDS 97521..98336 FT /transl_table=11 FT /locus_tag="Rv2248" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2248, (MTCY427.29), len: 271 aa. Conserved FT hypothetical protein. Very similar to hypothetical M. FT tuberculosis proteins Rv3517, Rv1482c, Rv3555c, Rv3714c, FT Rv1073. FASTA score: MTCY06G11.02c MTCY6G11 NID: g1877284 - FT (289 aa) opt: 366 E(): 5.3e-18; (32.1% identity in 249 aa FT overlap). Some similarity to Mycobacterium avium protein FT AF002133|AF0021 339 AF002133 NID: g2183254 (346 aa) opt: FT 308 E(): 5.2e-14; (28.3% identity in 254 aa overlap)" FT /db_xref="GOA:Q10526" FT /db_xref="UniProtKB/Swiss-Prot:Q10526" FT /protein_id="CAA94643.1" FT /translation="MTRQQLDVQVKNGGLVRVWYGVYAAQEPDLLGRLAALDVFMGGHA FT VACLGTAAALYGFDTENTVAIHMLDPGVRMRPTVGLMVHQRVGARLQRVSGRLATAPAW FT TAVEVARQLRRPRALATLDAALRSMRCARSEIENAVAEQRGRRGIVAARELLPFADGRA FT ESAMESEARLVMIDHGLPLPELQYPIHGHGGEMWRVDFAWPDMRLAAEYESIEWHAGPA FT EMLRDKTRWAKLQELGWTIVPIVVDDVRREPGRLAARIARHLDRARMAG" FT repeat_region 98345..98397 FT /note="53 bp inverted repeat between 3' ends of MTCY427.29 FT and MT CY427.31c" FT CDS complement(98402..99952) FT /transl_table=11 FT /gene="glpD1" FT /locus_tag="Rv2249c" FT /product="PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE FT GLPD1" FT /function="INVOLVED IN AEROBIC RESPIRATION AND OXYDATION OF FT GLYCEROL. REDUCES AN ACCEPTOR AND GENERATES GLYCERONE FT PHOSPHATE FROM Sn-GLYCEROL 3-PHOSPHATE. POSSIBLY PLAY A FT ROLE IN METABOLISM OF RIBOFLAVIN, FAD,FMN [CATALYTIC FT ACTIVITY: SN-GLYCEROL 3-PHOSPHATE + ACCEPTOR = GLYCERONE FT PHOSPHATE + REDUCED ACCEPTOR]." FT /EC_number="1.1.99.5" FT /note="Rv2249c, (MTCY427.31c), len: 516 aa. Probable glpD1, FT glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), similar FT to SW:GLPD_ECOLI P13035 aerobic glycerol-3-phosphate FT dehydrogenase (30.0% identity in 486 aa overlap) and FT SW:GLPA_ECOLI P13032 anaerobic glycerol-3-phosphate FT dehydrogenase (28.2% identity in 504 aa overlap). Also FT similar to Rv3302c|glpD2 glycerol-3-phosphate FT dehydrogenase. COFACTOR: FAD (BY SIMILARITY). BELONGS TO FT THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FT FAMILY." FT /db_xref="GOA:P64182" FT /db_xref="InterPro:IPR006076" FT /db_xref="UniProtKB/Swiss-Prot:P64182" FT /protein_id="CAA94644.1" FT /translation="MLMPHSAALNAARRSADLTALADGGALDVIVIGGGITGVGIALDA FT ATRGLTVALVEKHDLAFGTSRWSSKLVHGGLRYLASGNVGIARRSAVERGILMTRNAPH FT LVHAMPQLVPLLPSMGHTKRALVRAGFLAGDALRVLAGTPAATLPRSRRIPASRVVEIA FT PTVRRDGLDGGLLAYDGQLIDDARLVMAVARTAAQHGARILTYVGASNVTGTSVELTDR FT RTRQSFALSARAVINAAGVWAGEIDPSLRLRPSRGTHLVFDAKSFANPTAALTIPIPGE FT LNRFVFAMPEQLGRIYLGLTDEDAPGPIPDVPQPSSEEITFLLDTVNTALGTAVGTKDV FT IGAYAGLRPLIDTGGAGVQGRTADVSRDHAVFESPSGVISVVGGKLTEYRYMAEDVLNR FT AITLRHLRAAKCRTRNLPLIGAPANPGPAPGSGAGLPESLVARYGAEAANVAAAATCER FT PTEPVADGIDVTRAEFEYAVTHEGALDVDDILDRRTRIGLVPRDRERVVAVAKEFLSR" FT CDS complement(99946..100515) FT /transl_table=11 FT /locus_tag="Rv2250c" FT /product="Possible transcriptional regulatory protein" FT /function="Possibly involved in transcriptional regulation" FT /note="Rv2250c, (MTCY427.32c), len: 189 aa. Possible FT transcriptional regulatory protein, TetR family. Start FT unclear; ORF has been shortened since first submission to FT avoid overlap with Rv2251 (-30 aa). Contains probable FT helix-turn-helix motif (Score 2243, +6.70 SD)" FT /db_xref="GOA:Q10528" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:Q10528" FT /protein_id="CAA94669.2" FT /translation="MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRP FT TVYRRWPDTRSIMASMLTSHIADVLREVPLDGDDREALVKQIVAVADRLRGDDLIMSVM FT HSELARVYITERLGTSQQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQSTIQS FT ADIVDSILDSAALATELTHALNGYLC" FT CDS 100563..100982 FT /transl_table=11 FT /locus_tag="Rv2250A" FT /product="POSSIBLE FLAVOPROTEIN" FT /function="ELECTRON ACCEPTOR" FT /note="Rv2250A, len: 139 aa. Conserved hypothetical FT protein, possibly flavoprotein. Similar to N-terminus of FT SCF91.28c|AL132973_28 possible flavoprotein from FT Streptomyces coelicolor (530 aa), FASTA scores: opt: 240, FT E(): 1.1e-07, (39.25% identity in 107 aa overlap). Possible FT frameshift between nt 2525723 to 2525727. The sequences of FT CDC 1551 and Mycobacterium bovis are missing a single G FT base." FT /db_xref="UniProtKB/TrEMBL:Q79FG6" FT /protein_id="CAE55464.1" FT /translation="MKWDAWGDPAAAKPLSDGVRSLLKQVVGLADSEQPELDPAQVQLR FT PSALSGADHDALARIVGTEYFRTADRDRLLHAGGKSTPDLLRRKDTGVQDAPDAVLLPG FT GPNGGGRRRRHLALLLRPRHCRGPVWWRHQRRWWA" FT CDS 100726..102153 FT /transl_table=11 FT /locus_tag="Rv2251" FT /product="POSSIBLE FLAVOPROTEIN" FT /function="ELECTRON ACCEPTOR" FT /note="Rv2251, (MTV022.01), len: 475 aa. Possible FT flavoprotein, probably continuation of Rv2250A, similar to FT MTCY164.18 from Mycobacterium tuberculosis and to several FT ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASES (e.g. O00116). FT Also some similarity to D-lactate dehydrogenases. FASTA FT scores: sptr|O05784|O05784 HYPOTHETICAL 56.5 kDa PROTEIN. FT (527 aa) opt: 1019 E(): 0; (38.6% identity in 487 aa FT overlap) and sp|O00116|ADAS_HUMAN ALKYLDIHYDROXYACETON FT EPHOSPHATE SYNTHASE PRECURSOR (EC 2.5.1.26) (658 aa) opt: FT 558 E(): 6.2e-27; (31.3% identity in 447 aa overlap). FT TBparse score is 0.902" FT /db_xref="GOA:O53525" FT /db_xref="InterPro:IPR006094" FT /db_xref="UniProtKB/TrEMBL:O53525" FT /protein_id="CAA17288.1" FT /translation="MRWRASSAPSISAPPIATGCCTPAASPPQTCCGAKTPVSRMRPTR FT CCCPAAPTGEDAVADILHYCSDHGIAVVPFGGGTSVVGGLDPVRNDFRAVISLDMRRFD FT RLHRIDEVSGEAELEAGVTGPEAERLLGEHGFSLGHFPQSFEFATIGGFAATRSSGQDS FT AGYGRFNDMILGLRMITPVGVLDLGRVPASAAGPDLRQLAIGSEGVFGVITRVRLRVHR FT IPESTRYEAWSFPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQIT FT GGCLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPYLRDSLLA FT AGALCETLETATVWSNTPVLKAAVTEALTTSLAASGTPALVMCHVSHVYPTGASLYFTV FT VAGQRGDPIEQWLAAKKAASDAIMATGGTITHHHAVGSDHRPWMRAEVGDLGVTLLRTI FT KATLDPAGILNPGKLIP" FT CDS 102150..103079 FT /transl_table=11 FT /locus_tag="Rv2252" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2252, (MTV022.02), len: 309 aa. Conserved FT hypothetical protein, similar to hypothetical proteins from FT Bacillus subtilis (e.g. BSUB0004_120), Streptomyces FT coelicolor A3(2) >emb|CAB61184.1| (AL132973) hypothetical FT protein SCF91.27c (293 aa) and P39074. FASTA scores: FT Z99107|BSUB0004_120 Bacillus subtilis complete genome (303 FT aa) opt: 397, E(): 1.7e-19; (26.4% identity in 299 aa FT overlap) and P390 74|BMRU_BACSU BMRU PROTEIN (297 aa) opt: FT 309, E(): 1.3e-13; (25.0% identity in 284 aa overlap). FT TBparse score is 0.910" FT /db_xref="GOA:O53526" FT /db_xref="InterPro:IPR005218" FT /db_xref="UniProtKB/TrEMBL:O53526" FT /protein_id="CAA17289.1" FT /translation="MSAGQLRRHEIGKVTALTNPLSGHGAAVKAAHGAIARLKHRGVDV FT VEIVGGDAHDARHLLAAAVAKGTDAVMVTGGDGVVSNALQVLAGTDIPLGIIPAGTGND FT HAREFGLPTKNPKAAADIVVDGWTETIDLGRIQDDNGIEKWFGTVAATGFDSLVNDRAN FT RMRWPHGRMRYYIAMLAELSRLRPLPFRLVLDGTEEIVADLTLADFGNTRSYGGGLLIC FT PNADHSDGLLDITMAQSDSRTKLLRLFPTIFKGAHVELDEVSTTRAKTVHVECPGINVY FT ADGDFACPLPAEISAVPAALQVLRPRHG" FT CDS 103145..103648 FT /transl_table=11 FT /locus_tag="Rv2253" FT /product="Possible secreted unknown protein" FT /function="UNKNOWN" FT /note="Rv2253, (MTV022.03), len: 167 aa. Possible secreted FT protein; has potential N-terminal signal peptide. TBparse FT score is 0.945." FT /db_xref="UniProtKB/TrEMBL:O53527" FT /protein_id="CAA17290.1" FT /translation="MSGHRKKAMLALAAASLAATLAPNAVAAAEPSWNGQYLVTLSANA FT KTGTSMAANRPEYPHKANYTFSSRCASDVCIATVVDAPPPKNEFIPRPIEYTWNGTQWV FT REISWQWDCLLPDGTIEYAPAKSITAYTPGQYGILTGVFHTDIASGTCKGNVDMPVSAK FT PIVG" FT CDS complement(103681..104136) FT /transl_table=11 FT /locus_tag="Rv2254c" FT /product="Probable integral membrane protein" FT /function="UNKNOWN" FT /note="Rv2254c, (MTV022.04c), len: 151 aa. Probable FT integral membrane protein. TBparse score is 0.928." FT /db_xref="UniProtKB/TrEMBL:O53528" FT /protein_id="CAA17291.1" FT /translation="MRYRDLETVAAPTINVLRVWPEIVGAIVLLVIAAMGIGHGLRPSP FT EPVPAPQKQLGCVRFALIFGLTAINPATFVYFTAVAVTLARALRATTAIAVVVGVALAS FT LLWQLLLVSAGAFLRSRATARVRRMTVLAGNAVIAAFGAVLVVHAFA" FT CDS complement(104141..104335) FT /transl_table=11 FT /locus_tag="Rv2255c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2255c, (MTV022.05c), len: 64 aa. Hypothetical FT unknown protein. TBparse score is 0.904." FT /db_xref="UniProtKB/TrEMBL:O53529" FT /protein_id="CAA17292.1" FT /translation="MDGIVDRGVRARPCQKVVAVLRRSKSHIDKRLDAATGNAFLGKQV FT LSAAGVVEYRPPRRSPLST" FT CDS complement(104502..105035) FT /transl_table=11 FT /locus_tag="Rv2256c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2256c, (MTV022.06c), len: 177 aa. Conserved FT hypothetical protein, similar to Streptomyces glaucescens FT ORF5 (164 aa) and Streptomyces coelicolor hypothetical FT protein SC4A7.19c (164 aa; emb|CAB62723.1|AL133423). FASTA FT scores: sptr|Q54209|Q54209 FABD, FABH, FABC, FABB, AND ORF5 FT (164 aa) opt: 504, E(): 3.9e-27; (44.4% identity in 162 aa FT overlap). TBparse score is 0.900" FT /db_xref="UniProtKB/TrEMBL:O53530" FT /protein_id="CAA17293.1" FT /translation="MEPKEQQMRASNQFADVTSGVVYIHASPAAVCPHVEWALSSTLQA FT KANLVWTPQPALPPQLRAVTNWVGPVGTGARLANALRSWSVLRFEVTEDPSPGVDGQRF FT SHTPQLGLWSGAMSANGDIMVGEMRLRAMMAQGADTLAAELDSVLGTAWDQALEVYRDG FT GDAGEVTWLSRGVG" FT CDS complement(105165..105983) FT /transl_table=11 FT /locus_tag="Rv2257c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2257c, (MTV022.07c), len: 272 aa. Conserved FT hypothetical protein, similar to hypothetical protein FT SC4A7.08 from Streptomyces coelicolor (273 aa; 58% identity FT in 243 aa overlap). Also similar to several putative FT esterases and penicillin-binding proteins in M. FT tuberculosis e.g. Rv1923, Rv1497, Rv2463, Rv3775, Rv1922, FT Rv1730c. TBparse score is 0.896." FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:O53531" FT /protein_id="CAA17294.1" FT /translation="MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPL FT VARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYSNYGF FT TVLAESVQRESGIEFGRYLTEAVCEPLGMVTTRLDGGPAAAGFGATSTVADLAVFAGDL FT LRPSTVSAQMHADATTVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTR FT TFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT" FT CDS complement(105997..107058) FT /transl_table=11 FT /locus_tag="Rv2258c" FT /product="Possible transcriptional regulatory protein" FT /function="Possibly involved in transcriptional regulation" FT /note="Rv2258c, (MTV022.08c), len: 353 aa. Possible FT transcriptional regulatory protein, similar to several FT hypothetical proteins from C. elegans. FASTA scores: FT sptr|O01593|O01593 CODED FOR BY C. ELEGANS CDNA YK102 F FT (365 aa) opt: 577, E(): 6.4e-31; (30.5% identity in 341 aa FT overlap). Contains possible helix-turn helix motif at aa FT 47-68 (+3.65 SD)" FT /db_xref="GOA:O53532" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:O53532" FT /protein_id="CAA17295.1" FT /translation="MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPP FT ATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLA FT VIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVD FT GLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLAN FT ATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQ FT LEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEI FT ESDVLNNYYIARK" FT repeat_region complement(107059..107111) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region complement(107112..107164) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region complement(107165..107217) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region complement(107218..107270) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region complement(107271..107323) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region complement(107324..107373) FT /note="50 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 107406..108491 FT /transl_table=11 FT /gene="adhE2" FT /locus_tag="Rv2259" FT /product="Probable zinc-dependent alcohol dehydrogenase FT AdhE2" FT /function="oxido-reduction" FT /EC_number="1.2.1.-" FT /note="Rv2259, (MTV022.09), len: 361 aa. Probable adhE2, FT zinc-containing alcohol dehydrogenase, similar to several, FT especially mycothiol-dependent formaldehyde dehydrogenase FT from Amycolatopsis methanolica P80094 (360 aa). Contains FT PS00059 Zinc-containing alcohol dehydrogenases signature. FT FASTA scores: >sp|P80094|FADH_AMYME NAD/MYCOTHIOL-DEPENDENT FT FORMALDEHYDE DEHYDROGENASE (MD-FALDH) Length = 360, Expect FT = e-156, Identities = 268/358 (74%). TBparse score is FT 0.882. Also similar to Rv0162c, (MTCI28.02c, 35.0% identity FT in 371 aa overlap)." FT /db_xref="GOA:O53533" FT /db_xref="HSSP:1A71" FT /db_xref="InterPro:IPR013154" FT /db_xref="UniProtKB/TrEMBL:O53533" FT /protein_id="CAA17296.1" FT /translation="MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTD FT LTYREGGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACKRGRP FT RYCFDTFNAEQKMTLTDGTELTAALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCG FT VMAGLGAAINTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWART FT FGATHTVNAREVDVVQAIGGLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVP FT TPDMRLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLE FT DVEEAFHKMHGGKVLRSVVML" FT misc_feature 107589..107633 FT /note="PS00059 Zinc-containing alcohol dehydrogenases FT signature" FT CDS 108491..109126 FT /transl_table=11 FT /locus_tag="Rv2260" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2260, (MTV022.10), len: 211 aa. Conserved FT hypothetical protein, similar to hypothetical proteins FT Rv0634c, Rv1637c, Rv3677c, Rv2581c from Mycobacterium FT tuberculosis and to various hydrolases. FASTA scores: FT sptr|O06154|O06154 HYPOTHETICAL 21.3 kDa PROTEIN (200 aa) FT opt: 355, E(): 4e- 15; (37.4% identity in 198 aa overlap). FT TBparse score is 0.901" FT /db_xref="GOA:O53534" FT /db_xref="HSSP:1QH5" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:O53534" FT /protein_id="CAA17297.1" FT /translation="MAAIERVITHGTFELDGGSWEVDNNIWLVGDDSEVVVFDAAHHAA FT PIIDAVGGRKVVAVICTHGHNDHVTVAPELGTALDAPVLMHPGDAVLWRMTHPDKSFRA FT VSDGDAVRVGGTELRALHTPGHSPGSVCWYAPELGPGTGTVFSGDTLFAGGPGATGRSY FT SDFPTILRSISGRLGALPGDTVVHTGHGDSTTIGDEIVHYEEWVARGH" FT CDS complement(109203..109625) FT /transl_table=11 FT /locus_tag="Rv2261c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="Function unknown; thought to be involved in FT lipid metabolism." FT /note="Rv2261c, (MTV022.11c), len: 140 aa. Conserved FT hypothetical protein, with function unknown but some FT similarity to C-terminal end of PCC6803 apolipoprotein FT N-acyltransferase from Synechocystis sp. Note that next ORF FT shows similarity to N-terminal part of P74055 FT APOLIPOPROTEIN N-ACYLTRANSFERASE from Escherichia coli (519 FT aa), FASTA scores: opt: 142, E(): 0.007, (29.9% identity in FT 117 aa overlap), suggesting possible frameshift. Sequence FT of clones from two sources has been checked but no error FT found. TBparse score is 0.914." FT /protein_id="CAA17298.1" FT /translation="MHIAPLISYEMTFSDLTRHAARLGAALLVYQSSTSTFQGSWAQPQ FT LAAQPAVRAVEAGIPAVHASLSGDSSAFDTRGRRLAWCSAEFNGAIVVNVPLASNVTLY FT LRLGDWVPVTAFVVMGAGFAVFLRRSLARVSDCADK" FT CDS complement(109631..110713) FT /transl_table=11 FT /locus_tag="Rv2262c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="Function unknown; thought to be involved in FT lipid metabolism." FT /note="Rv2262c, (MTV022.12c), len: 360 aa. Conserved FT hypothetical protein, with function unknown but some FT similarity to N-terminal 70% of FT P23930|P77703|LNT_ECOLI|CUTE|B0657 APOLIPOPROTEIN FT N-ACYLTRANSFERASE (EC 2.3.1.-) from Escherichia coli strain FT K12 (512 aa), FASTA scores: opt: 239, E(): 1.6e-07, (30.4% FT identity in 359 aa overlap). Note that neighboring ORF FT shows similarity to N -terminal part of PCC6803 FT apolipoprotein N-acyltransferase from Synechocystis sp., FT suggesting possibility of frameshift. Sequence of clones FT from two sources has been checked but no error found. FT Appear to be two extra bases at position 1876970 compared FT to CDC1551 strain. TBparse score is 0.932." FT /db_xref="GOA:O53536" FT /db_xref="InterPro:IPR003010" FT /db_xref="UniProtKB/TrEMBL:O53536" FT /protein_id="CAA17299.1" FT /translation="MALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVPL FT LLVVRAAPTSWEGALRAWTGMGGFVLATQYWLVTSAGPMLVLLAAGLGVLWLPAGWLAH FT RLLSVPVTTCRVGAALVVVPSAWVAAEAVRSWQSLGGPWALLGASQWSQPVTLASASLG FT GVWLTSFLLVATNTAIASVLVCRATGGRLVALGCVIGCAGLGPASYLLGSVPVGGPTVR FT VALVQAGDIADAAARLAAGEEFTAAVADQRPDLVVWGESSVGQDLTRHPDVLARLAELS FT QRVGADLLVNVDAPAPDGGIYKSAVLVGAHEAVGSYRKTRLVPFGEYVLRCARFSAGSP FT ATARPPQRIGSAAPGRWCWR" FT CDS 110802..111755 FT /transl_table=11 FT /locus_tag="Rv2263" FT /product="Possible oxidoreductase" FT /function="oxidoreduction" FT /EC_number="1.-.-.-" FT /note="Rv2263, (MTV022.13), len: 317 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to several FT oxidoreductases. Similarity suggests alternative GTG start FT at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q54405 FT PROBABLY AN NADP-DEPENDENT OXIDOREDUCTASE (297 aa) opt: FT 487, E(): 1.1e-23; (36.1% identity in 299 aa overlap). Also FT similar to Mycobacterium tuberculosis Rv0068, and Rv0439c. FT TBparse score is 0.889" FT /db_xref="GOA:O53537" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O53537" FT /protein_id="CAA17300.1" FT /translation="MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMAI FT RNRAKGEAAVEEIRTAVPDAKLTIKALDLSSLASVAALGEQLMADGRPIDLLINNAGVM FT TPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRAAQRARVVSLSSLAARRGRIHFDD FT LQFERSYAPMTAYGQSKLAVLMFARELDRRSRAAGWGIISNAAHPGLTKTNLQIAGPSH FT GRDKPALMERLYKTSWRFAPFLWQEIEEGILPALYAAATPQADGGAFYGPRGRYEVAGG FT GVREAKVPAAARNDADSKRLWEVSEQLTGVSYPKSR" FT CDS complement(111733..113511) FT /transl_table=11 FT /locus_tag="Rv2264c" FT /product="conserved hypothetical proline rich protein" FT /function="UNKNOWN" FT /note="Rv2264c, (MTV022.14c), len: 592 aa. Conserved FT hypothetical Pro-rich protein, similar to hypothetical FT proteins Rv0312 (MTCY63.17, 620 aa and Rv0350) that has FT highly Pro-, Thr-rich C-terminus. Contains PS00343 FT Gram-positive cocci surface proteins 'anchoring' FT hexapeptide. FASTA scores: Z96800|MTCY63_17 Mycobacterium FT tuberculosis cosmid (620 aa) opt: 1075, E(): 8.8e-24; FT (38.9% identity in 627 aa overlap). TBparse score is 0.919" FT /db_xref="GOA:O53538" FT /db_xref="InterPro:IPR002731" FT /db_xref="UniProtKB/TrEMBL:O53538" FT /protein_id="CAA17301.1" FT /translation="MATGARPALGLSIGVTNLAAVAADHSITRKPVLTLYRQRPPEVGV FT PSENPRLDEPGLVITDFVDRVGDSVGIVAADGSVYRSEALVADALLALAYTATGGRALP FT GSVTVTYPAHWGPAAVAALDSALRRASEWSHGTSSTAQPLSLLPDAAAALYAIRADPGI FT PARGIVAVCDFGGSGTGITLVDAADEYRPVAATVRHQAFSGDLIDQSLLSYVMSELPGT FT GAFDPAGTSAIGSLTKLRIECRKAKERLSSSTVTTLTDALGGDIRLTRNELEDTIRDSL FT DSVGRALEQTLARSGIRTAELVAIVSVGGGANIPAVTTTLSGRFCVPVVRTPRPQLTAA FT FGGALWAARRPGDTSATVLTAVTSATATAPADAPASVLQPALAWSEADEDSHIGPAPGY FT TAARPSLSFDHDAHAEPEPKSPPIPWYRLPAVIITGTTVAVLLVGAAVAIGLSTGDQPT FT APGTPQRPGVTTTAAPPPSPAPASDGPTTEPAPPVQAPATGGPAPPLQQPLPPPPTTTN FT TQPAVTTDVITPAPTTPASAPPATTQPPATTQPPATTSPSPPPIPPIPPIPEIPQLPPG FT IPQVPGIGQFSAISGS" FT misc_feature complement(112840..112857) FT /note="PS00343 Gram-positive cocci surface proteins FT 'anchoring' hexapeptide" FT CDS 113861..115090 FT /transl_table=11 FT /locus_tag="Rv2265" FT /product="Possible conserved integral membrane protein" FT /function="UNKNOWN" FT /note="Rv2265, (MTCY339.45c), len: 409 aa. Possible FT conserved integral membrane protein, with some similarity FT to others e.g. M. thermoauto. sp|O26855|O26855 CONSERVED FT PROTEIN (383 aa), FASTA score: opt: 898 z-score: 1023.5 FT E(): 0; 38.0% identity in 384 aa overlap; Q58713 FT HYPOTHETICAL 44.1 kDa PROTEIN 1 317 (398 aa), FASTA scores, FT opt: 305 E(): 1.2e-11; 22.8% identity in 382 aa overlap; FT also KGTP_ECOLI P17448 alpha-ketoglutarate permease (432 FT aa), FASTA scores, opt: 156, E(): 0.006, (24.8% identity in FT 416 aa overlap)" FT /db_xref="GOA:P64961" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/Swiss-Prot:P64961" FT /protein_id="CAB00970.1" FT /translation="MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSI FT TGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVP FT LLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMI FT GPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSA FT PRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALT FT ALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGV FT VADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMF FT AIRLPRVAPS" FT CDS 115265..116551 FT /transl_table=11 FT /gene="cyp124" FT /locus_tag="Rv2266" FT /product="Probable cytochrome P450 124 CYP124" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv2266, (MT2328, MTCY339.44c), len: 428 aa. Probable FT cyp124, cytochrome P450 (EC 1.14.-.-), similar to e.g. FT G405543 cytochrome P450 (406 aa), FASTA scores, opt: FT 763,E(): 0, (35.4% identity in 393 aa overlap), similar to FT e.g. MTCY50.26, 33.8% identity in 370 aa overlap" FT /db_xref="GOA:P0A516" FT /db_xref="HSSP:1CPT" FT /db_xref="InterPro:IPR017972" FT /db_xref="UniProtKB/Swiss-Prot:P0A516" FT /protein_id="CAB00969.1" FT /translation="MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFAT FT LRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNITINDQTPELA FT EYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADL FT VSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSADIGAY FT ATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVL FT ALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVS FT LWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQ FT MPDVVATEEPARLLSQFIHGIKTLPVTWS" FT CDS complement(116805..117971) FT /transl_table=11 FT /locus_tag="Rv2267c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2267c, (MTCY339.43), len: 388 aa. Conserved FT hypothetical protein; some similarity to Mycobacterium FT tuberculosis Rv3529c; gp|Z82098|MTCY3C7_27 (384 aa) FASTA FT score: opt: 261, E(): 3.6e-10; 27.3% identity in 253 aa FT overlap" FT /db_xref="GOA:P64963" FT /db_xref="InterPro:IPR000863" FT /db_xref="UniProtKB/Swiss-Prot:P64963" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00968.1" FT /translation="MKALRSSSRLSRWREWAAPLWVGCNFSAWMRLLIRNRFAVHHSRW FT HFAVLYTFLSMVNSCLGLWQKIVFGRRVAETVIADPPIFIVGHWRTGTTLLHELLVVDD FT RHTGPTGYECLAPHHFLLTEWFAPYVEFLVSKHRAMDNMDLSLHHPQEDEFVWCMQGLP FT SPYLTIAFPNRPPQYEEYLDLEQVAPRELEIWKRTLFRFVQQVYFRRRKTVILKNPTHS FT FRIKVLLEVFPQAKFIHIVRDPYVVYPSTIHLHKALYRIHGLQQPTFDGLDDKVVSTYV FT DLYRKLDEGRELVDPTRFYELRYEDLIGDPEGQLRRLYQHLGLGDFECYLPRLRQYLAD FT HADYKTNSYQLTVEQRAIVDEHWGEIIDRYGYDRHTPEPARLRPAVGG" FT CDS complement(117968..119437) FT /transl_table=11 FT /gene="cyp128" FT /locus_tag="Rv2268c" FT /product="PROBABLE CYTOCHROME P450 128 CYP128" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable FT cyp128, cytochrome P450 (EC 1.14.-.-), similar to (but FT longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 FT cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, FT E(): 8.3e-33, (31.8% identity in 406 aa overlap); contains FT PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature, similar to MTCY50.26, 32.7% identity in 382 aa FT overlap" FT /db_xref="GOA:P63713" FT /db_xref="HSSP:1IO7" FT /db_xref="InterPro:IPR017972" FT /db_xref="UniProtKB/Swiss-Prot:P63713" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00967.1" FT /translation="MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTRR FT RASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDFDP FT FDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVTFSR FT GWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPADVVST FT VAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGFRRLRA FT LFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMISTLFLT FT LADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPAGSLVLLA FT WGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILREIVANIDR FT IEVVEPPTWTTNANLRGLTRLRVAVTPRVAP" FT misc_feature complement(118127..118156) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(119450..119782) FT /transl_table=11 FT /locus_tag="Rv2269c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; FT questionable ORF." FT /db_xref="UniProtKB/Swiss-Prot:P64965" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00966.1" FT /translation="MANDARPLARLANCRVGDQSSATHAYTVGPVLGVPPTGGVDLRYG FT GRAGIGRSETVTDHGAVGRRYHQPCAGQIRLSELRVTILLRCETLCETAQLLRCPPLPC FT DCSTPL" FT CDS 119859..120386 FT /transl_table=11 FT /gene="lppN" FT /locus_tag="Rv2270" FT /product="PROBABLE LIPOPROTEIN LPPN" FT /function="UNKNOWN" FT /note="Rv2270, (MTCY339.40c), len: 175 aa. Probable lppN, FT lipoprotein; has appropriately positioned prokaryotic FT membrane lipoprotein attachment site PS00013." FT /db_xref="GOA:Q50693" FT /db_xref="UniProtKB/Swiss-Prot:Q50693" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00965.1" FT /translation="MRLPGRHVLYALSAVTMLAACSSNGARGGIASTNMNPTNPPATAE FT TATVSPTPAPQSARTETWINLQVGDCLADLPPADLSRITVTIVDCATAHSAEVYLRAPV FT AVDAAVVSMANRDCAAGFAPYTGQSVDTSPYSVAYLIDSHQDRTGADPTPSTVICLLQP FT ANGQLLTGSARR" FT CDS 120493..120792 FT /transl_table=11 FT /locus_tag="Rv2271" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2271, (MTCY339.39c), len: 99 aa. Conserved FT hypothetical protein; some similarity to hypothetical FT protein AAK01340.1|AF265275_3 (AF265275) from uncultured FT organism Pu8 (104 aa) E= 4e-10, (34% identity in 91 aa FT overlap)" FT /db_xref="UniProtKB/Swiss-Prot:P64967" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00964.1" FT /translation="MTTPPDKARRRFLRDAYKNAERVARTALLTIDQDQLEQLLDYVDE FT RLGEQPCDHTARHAQRWAQSHRIEWETLAEGLQEFGGYCDCEIVMNVEPEAIFG" FT CDS 120898..121266 FT /transl_table=11 FT /locus_tag="Rv2272" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2272, (MTCY339.38c), len: 122 aa. Probable FT conserved transmembrane PROTEIN, similar to YIDH_ECOLI FT P31445 hypothetical 12.8 kDa protein (115 aa), FASTA FT scores, opt: 291, E(): 2.9e-14, (45.6% identity in 103 aa FT overlap), similar to MTCY339.37c, (35.0% identity in 100 aa FT overlap)." FT /db_xref="GOA:P64969" FT /db_xref="InterPro:IPR003807" FT /db_xref="UniProtKB/Swiss-Prot:P64969" FT /protein_id="CAB00963.1" FT /translation="MADDSNDTATDVEPDYRFTLANERTFLAWQRTALGLLAAAVALVQ FT LVPELTIPGARQVLGVVLAILAILTSGMGLLRWQQADRAMRRHLPLPRHPTPGYLAVGL FT CVVGVVALALVVAKAITG" FT CDS 121263..121592 FT /transl_table=11 FT /locus_tag="Rv2273" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2273, (MTCY339.37c), len: 109 aa. Probable FT conserved transmembrane protein, similar to Rv2272 FT (MTCY339.38c), (35.0% identity in 100 aa overlap)." FT /db_xref="GOA:P64971" FT /db_xref="InterPro:IPR003807" FT /db_xref="UniProtKB/Swiss-Prot:P64971" FT /protein_id="CAB00962.1" FT /translation="MNRHSTAASDRGLQAERTTLAWTRTAFALLVNGVLLTLKDTQGAD FT GPAGLIPAGLAGAAASCCYVIALQRQRALSHRPLPARITPRGQVHILATAVLVLMVVTA FT FAQLL" FT CDS complement(121649..121966) FT /transl_table=11 FT /locus_tag="Rv2274c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2274c, (MTCY339.36), len: 105 aa. Unknown protein; FT questionable ORF." FT /db_xref="UniProtKB/Swiss-Prot:Q50689" FT /protein_id="CAB00961.1" FT /translation="MSIARSAQPIGWISCPPKGGSSCCRCGGGYTHIFCVSAWTGLVVD FT LQAEQVRSVVTERLRRRIGRGAPILAGTLAPGVGLAAQNREFRQFTGRSAPPSATIAFG FT E" FT CDS 122044..122913 FT /transl_table=11 FT /locus_tag="Rv2275" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2275, (MTCY339.35c), len: 289 aa. Conserved FT hypothetical protein. Some similarity to Bacillus subtilis FT sp|O34351|O34351 YVMC (248 aa), FASTA score: opt: 280, E(): FT 2.7e -11; 28.2% identity in 227 aa overlap" FT /db_xref="UniProtKB/TrEMBL:Q50688" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00960.1" FT /translation="MSYVAAEPGVLISPTDDLQSPRSAPAAHDENADGITGGTRDDSAP FT NSRFQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGL FT WGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGA FT RLCVRPMSEFQSNEAYRELHADLLTRLKDDEDLRAVCQDLVRRFLSTKVGPRQGATATQ FT EQVCMDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAEMLYARGSGLRASRNQGHAIV FT TPDGSPAE" FT CDS 122910..124100 FT /transl_table=11 FT /gene="cyp121" FT /locus_tag="Rv2276" FT /product="CYTOCHROME P450 121 CYP121" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS. IT HAS BEEN SHOWN TO BIND TIGHLY TO A RANGE OF FT AZOLE-BASED ANTIFUNGAL DRUGS (e.g. MICONAZOLE, FT CLOTRIMAZOLE)." FT /EC_number="1.14.-.-" FT /note="Rv2276, (MT2336, MTCY339.34c), len: 396 aa. cyp121, FT cytochrome P450 (EC 1.14.-.-) (see citation below), similar FT to e.g. G303644 (397 aa) opt: 675, z-score: 776.4, E(): FT 2.7e-36, (33.7% identity in 407 aa overlap); contains FT PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature, similar to MTCY339.42, 29.2% identity in 298 aa FT overlap." FT /db_xref="GOA:P0A514" FT /db_xref="InterPro:IPR017972" FT /db_xref="PDB:1N40" FT /db_xref="UniProtKB/Swiss-Prot:P0A514" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00959.1" FT /translation="MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLV FT SSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITP FT KAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRS FT LSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDEL FT FATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFA FT DGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGR FT GQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW" FT misc_feature 123921..123950 FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(124285..125190) FT /transl_table=11 FT /locus_tag="Rv2277c" FT /product="Possible glycerolphosphodiesterase" FT /function="UNKNOWN" FT /note="Rv2277c, (MTCY339.33), len: 301 aa. Possible FT glycerolphosphodiesterase, similar to e.g. UGPQ_ECOLI FT P10908 glycerophosphoryldiester phosphodiesterase FT (cytosolic) (247 aa), FASTA scores, opt: 149, E(): 0.0061, FT (27.2% identity in 195 aa overlap). Start of protein FT uncertain, encoded by neighbouring IS6110 as given, is FT intact in Mycobacterium tuberculosis CDC1551" FT /db_xref="GOA:Q50687" FT /db_xref="InterPro:IPR017946" FT /db_xref="UniProtKB/Swiss-Prot:Q50687" FT /protein_id="CAB00958.1" FT /translation="MPGRFTVALVIALGGTCGVADALPLGQTDDPMIVAHRAGTRDFPE FT NTVLAITNAVAAGVDGMWLTVQVSSDGVPVLYRPSDLATLTDGAGPVNSKTVQQLQQLN FT AGWNFTTPGVEGHPYRQRATPIPTLEQAIGATPPDMTLFLDLKQTPPQPLVSAVAQVLT FT RTGAAGRSIVYSTNADITAAASRQEGLQVAESRDVTRQRLFNMALNHHCDPQPDPGKWA FT GFELHRDVTVTEEFTLGSGISAVNAELWDEASVDCFRSQSGMKVMGFAVKTVDDYRLAH FT KIGLDAVLVDSPLAAQQWRH" FT repeat_region 125172..125174 FT /note="3 bp direct repeat, ccg, flanking IS6110" FT repeat_region 125175..125202 FT /note="28 bp inverted repeat at the left end of IS6110, FT TGAACCGCCCCGGCATGTCCGGAGACTC" FT repeat_region 125175..126529 FT /mobile_element="insertion sequence:IS6110-7" FT /note="IS6110-7, len: 1355 bp. Insertion sequence IS6110." FT CDS 125226..125552 FT /transl_table=11 FT /locus_tag="Rv2278" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2278, (MTCY339.32c), len: 108 aa. Probable IS6110 FT transposase nearly identical to SW:YI32_MYCTU P19772 FT insertion element IS986 hypothetical (96.6% identity in 59 FT aa overlap), similar to TR:G309867 IS401 transposase FT subunit (51.4% identity in 105 aa overlap), predicted FT region of coiled coil at C-terminus." FT /db_xref="GOA:P0C5G9" FT /db_xref="InterPro:IPR002514" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9" FT /protein_id="CAB00989.1" FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD FT RPAR" FT CDS <125549..126487 FT /transl_table=11 FT /locus_tag="Rv2279" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS6110." FT /note="Rv2279, (MTCY339.31c), len: 312 aa. Probable IS6110 FT transposase , nearly identical to TRA9_MYCTU P19774 FT putative transposase for insertion sequence IS986 orfB, FT (278 aa), FASTA scores, opt: 1859, E(): 0, (99.6% identity FT in 278 aa overlap)." FT /db_xref="GOA:P0C5G8" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8" FT /protein_id="CAB00998.1" FT /translation="LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYDH FT INREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLG FT LSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVT FT DAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFS FT ERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWF FT NHRRLYQYCGDVPPVELEAAYYAQRQRPAAG" FT repeat_region 126502..126529 FT /note="28 bp inverted repeat at the right end of IS6110, FT GAGTCTCCGGACTCACCGGGGCGGTTCA" FT repeat_region 126530..126532 FT /note="3 bp direct repeat, ccg, flanking IS6110" FT CDS 126721..128100 FT /transl_table=11 FT /locus_tag="Rv2280" FT /product="Probable dehydrogenase" FT /function="oxidoreduction" FT /EC_number="1.-.-.-" FT /note="Rv2280, (MTCY339.30c), len: 459 aa. Probable FT dehydrogenase. Similar to D-lactate dehydrogenase FT (cytochrome) precursor e.g. G1061264 (587 aa), FASTA FT scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa FT overlap), similar to MTCY50.25, 36.5% identity in 447 aa FT overlap" FT /db_xref="GOA:Q50685" FT /db_xref="InterPro:IPR016168" FT /db_xref="UniProtKB/TrEMBL:Q50685" FT /protein_id="CAB00988.1" FT /translation="MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAK FT PATPEEVAQLLKAASENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEVDTANQ FT VAVVQPGVALTDLDAATADTGLRYTVYPGELSSSVGGNVGTNAGGMRAVKYGVARHNVL FT GLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSEGTLALVTEVIVKLHPRLDHNASVL FT APFADFDQVMAAVPKILASGLAPDILEYIDNTSMAALISTQNLELGIPDQIRDSCEAYL FT LVALENRIADRLFEDIQTVGEMLMELGAVDAYVLEGGSARKLIEAREKAFWAAKALGAD FT DIIDTVVPRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDPEKKKKLMTD FT IFALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQSFDPAGILNPGVVFGD FT T" FT CDS 128334..129992 FT /transl_table=11 FT /gene="pitB" FT /locus_tag="Rv2281" FT /product="Putative phosphate-transport permease PitB" FT /function="Involved in phosphate transport." FT /note="Rv2281, (MTCY339.29c), len: 552 aa. Putative pitB, FT phosphate-transport permease, integral membrane protein, FT similar to YG04_HAEIN P45268 putative phosphate permease FT hi1604 (420 aa). FASTA scores, opt: 484, E(): 5e-23, (33.5% FT identity in 498 aa overlap) also to G399598 amphotropic FT murine retrovirus receptor (656 aa) FASTA scores, opt: 453, FT E(): 5.8e-21, (26.8% identity in 645 aa overlap). Also FT similar to Rv0545c|pitA from M. tuberculosis. BELONGS TO FT THE PIT SUBFAMILY." FT /db_xref="GOA:P65712" FT /db_xref="InterPro:IPR001204" FT /db_xref="UniProtKB/Swiss-Prot:P65712" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00987.1" FT /translation="MSDNAKHHRDGHLVASGLQDRAARTPQHEGFLGPDRPWHLSFSLL FT LAGSFVLFSWWAFDYAGSGANKVILVLATVVGMFMAFNVGGNDVANSFGTSVGAGTLTM FT KQALLVAAIFEVSGAVIAGGDVTETIRSGIVDLSGVSVDPRDFMNIMLSALSAAALWLL FT FANRMGYPVSTTHSIIGGIVGAAIALGMVSGQGGAALRMVQWDQIGQIVVSWVLSPVLG FT GLVSYLLYGVIKRHILLYNEQAERRLTEIKKERIAHRERHKAAFDRLTEIQQIAYTGAL FT ARDAVAANRKDFDPDELESDYYRELHEIDAKTSSVDAFRALQNWVPLVAAAGSMIIVAM FT LLFKGFKHMHLGLTTMNNYFIIAMVGAAVWMATFIFAKTLRGESLSRSTFLMFSWMQVF FT TASGFAFSHGSNDIANAIGPFAAILDVLRTGAIEGNAAVPAAAMVTFGVALCAGLWFIG FT RRVIATVGHNLTTMHPASGFAAELSAAGVVMGATVLGLPVSSTHILIGAVLGVGIVNRS FT TNWGLMKPIVLAWVITLPSAAILASVGLVALRAIF" FT CDS complement(130099..131037) FT /transl_table=11 FT /locus_tag="Rv2282c" FT /product="Probable transcription regulator (lysR family)" FT /function="UNKNOWN" FT /note="Rv2282c, (MTCY339.28), len: 312 aa. Probable FT transcriptional regulator, lysR family, similar to others FT e.g. YC30_CYAPA|P48271 hypothetical transcriptional FT regulator YCF30 (324 aa), FASTA scores: opt: 292, E(): FT 4e-12, (27.6% identity in 286 aa overlap); etc. Also FT similar to Rv0377|MTCY39.34 from Mycobacterium FT tuberculosis, FASTA score: (25.4% identity in 268 aa FT overlap). Contains PS00044 Bacterial regulatory proteins, FT lysR family signature, and contains helix-turn-helix motif FT at aa 24 -45 (+4.93 SD)." FT /db_xref="GOA:P67667" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67667" FT /protein_id="CAB00986.1" FT /translation="MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRRLAS FT MEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSLRTEGRQRIRVVA FT SQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSEHAIAAVRDGIADLGFIENPCP FT PTGLGSVVVARDELVVVVPPGHKWARRSRVVSARELAQTPLVTREPNSGIRDSLTAALR FT DTLGEDMQQAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNL FT RRQLRAIWVGGRTPPAGAIRDLLSHITSRST" FT misc_feature complement(130888..130965) FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS 131102..131296 FT /transl_table=11 FT /locus_tag="Rv2283" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2283, (MTCY339.27c), len: 64 aa. Unknown protein; FT questionable ORF." FT /db_xref="UniProtKB/Swiss-Prot:P64973" FT /protein_id="CAB00985.1" FT /translation="MLEKCPHASVDCGASKIGITDNDPATATNRRLASTIRKPPIEHAA FT GPLGSTSRAGHRSYGGVAS" FT CDS 131306..132601 FT /transl_table=11 FT /gene="lipM" FT /locus_tag="Rv2284" FT /product="Probable esterase LipM" FT /function="Hydrolysis of lipids (bound ester)." FT /EC_number="3.1.-.-" FT /note="Rv2284, (MTCY339.26c), len: 431 aa. Probable lipM, FT esterase (EC 3.1.-.-), similar to others e.g. FT gp|Z95844|MTCY493_28 from Mycobacterium tuberculosis cosmid FT (420 aa), FASTA scores: opt: 1266, E(): 0, (50.1% identity FT in 411 aa overlap). Some similarity to G537514 FT arylacetamide deacetylase (399 aa), FASTA scores: opt: 190, FT E(): 5.9e-05, (30.4% identity in 138 aa overlap)." FT /db_xref="GOA:Q50681" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:Q50681" FT /protein_id="CAB00984.1" FT /translation="MGAPRLIHVIRQIGALVVAAVTAAATINAYRPLARNGFASLWSWF FT IGLVVTEFPLPTLASQLGGLVLTAQRLTRPVRAVSWLVAAFSALGLLNLSRAGRQADAQ FT LTAALDSGLGPDRRTASAGLWRRPAGGGTAKTPGPLRMLRIYRDYAHDGDISYGEYGRA FT NHLDIWRRPDLDLTGTAPVLFQIPGGAWTTGNKRGQAHPLMSHLAELGWICVAINYRHS FT PRNTWPDHIIDVKRALAWVKAHISEYGGDPDFIAITGGSAGGHLSSLAALTPNDPRFQP FT GFEEADTRVQAAVPFYGVYDFTRLQDAMHPMMLPLLERMVVKQPRTANMQSYLDASPVT FT HISADAPPFFVLHGRNDSLVPVQQARGFVDQLRQVSKQPVVYAELPFTQHAFDLLGSAR FT AAHTAIAVEQFLAEVYATQHAGSEPGPAVAIP" FT CDS 132634..133971 FT /transl_table=11 FT /locus_tag="Rv2285" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2285, (MTCY339.25c), len: 445 aa. Conserved FT hypothetical protein, member of Mycobacterium tuberculosis FT 15-membered protein family including Rv3740c, Rv3734c, FT Rv1425, Rv1760, Rv0895, Rv3480c. FASTA scores: FT gp|Z95844|MTCY493_29 Mycobacterium tuberculosis cosmid (459 FT aa) opt: 640, E(): 0; 33.4% identity in 470 aa overlap." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/Swiss-Prot:P67206" FT /protein_id="CAB00983.1" FT /translation="MKLLSPLDQMFARMEAPRTPMHIGAFAVFDLPKGAPRRFIRDLYE FT AISQLAFLPFPFDSVIAGGASMAYWRQVQPDPSYHVRLSALPYPGTGRDLGALVERLHS FT TPLDMAKPLWELHLIEGLTGRQFAMYFKAHHCAVDGLGGVNLIKSWLTTDPEAPPGSGK FT PEPFGDDYDLASVLAAATTKRAVEGVSAVSELAGRLSSMVLGANSSVRAALTTPRTPFN FT TRVNRHRRLAVQVLKLPRLKAVAHATDCTVNDVILASVGGACRRYLQELGDLPTNTLTA FT SVPVGFERDADTVNAASGFVAPLGTSIEDPVARLTTISASTTRGKAELLAMSPNALQHY FT SVFGLLPIAVGQKTGALGVIPPLFNFTVSNVVLSKDPLYLSGAKLDVIVPMSFLCDGYG FT LNVTLVGYTDKVVLGFLGCRDTLPHLQRLAQYTGAAFEELETAALP" FT CDS complement(134038..134730) FT /transl_table=11 FT /locus_tag="Rv2286c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2286c, (MTCY339.24), len: 230 aa. Conserved FT hypothetical protein. Similar to Mycobacterium tuberculosis FT hypothetical protein, Rv2466c, AL021246|MTV008_22 (207 aa). FT FASTA score: opt: 324, E(): 8.9e-15; 30.4% identity in 194 FT aa overlap" FT /db_xref="GOA:Q50679" FT /db_xref="InterPro:IPR001853" FT /db_xref="UniProtKB/Swiss-Prot:Q50679" FT /protein_id="CAB00982.1" FT /translation="MTTVDFHFDPLCPFAYQTSVWIRDVRAQLGITINWRFFSLEEINL FT VAGKKHPWERDWSYGWSLMRIGALLRRTNMSLLDRWYAAIGHELHTLGGKPHDPAVARR FT LLCDVGVNAAILDAALDDPTTHDDVRADHQRVVAAGGYGVPTLFLDGQCLFGPVLVDPP FT AGPAALNLWSVVTGMAGLPHVYELQRPKSPADVELIAQQLRPYLDGRDWVSINRGEIVD FT IDRLAGRS" FT CDS 134864..136492 FT /transl_table=11 FT /gene="yjcE" FT /locus_tag="Rv2287" FT /product="Probable conserved integral membrane transport FT protein YjcE" FT /function="possibly involved in transport of Na+/H+ across FT the membrane." FT /note="Rv2287, (MTCY339.23c), len: 542 aa. Probable yjcE, FT conserved integral membrane transport protein, similar to FT eukaryote NA+/H+ exchangers e.g. YJCE_ECOLI|P32703|B4065 FT Putative Na(+)/H(+) exchanger from Escherichia coli (549 FT aa), FASTA scores: opt: 436, E(): 5.6e-21, (29.4% identity FT in 555 aa overlap); etc. SEEMS TO BELONG TO CPA1 FAMILY FT (NA(+)/H(+) EXCHANGER FAMILY)." FT /db_xref="GOA:P65526" FT /db_xref="InterPro:IPR004705" FT /db_xref="UniProtKB/Swiss-Prot:P65526" FT /protein_id="CAB00981.1" FT /translation="MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLI FT LSGSLLGLIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIVMFSIGLVI FT ATAVAVSWTARALGMESHAAAVLGAVLSPTDAAAVAGLAKRLPRRALTVLRGESLINDG FT TALVLFAVTVAVAEGAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEE FT GALSLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFL FT INGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATRIAWVQATTVLGHTV FT DRVLKKPTRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVV FT ILVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRSAQAALDALPTVADELGVAPDL FT VKHLEKEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLID FT DIVLRELQAAMDLEEVQLLDPADAE" FT CDS 136489..136866 FT /transl_table=11 FT /locus_tag="Rv2288" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2288, (MTCY339.22c), len: 125 aa. Unknown FT hypothetical protein" FT /db_xref="UniProtKB/Swiss-Prot:P64975" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00980.1" FT /translation="MSRRRPLIEPATVQVLAIAFTDSFSVSLHWPQREQGCRTAILAPM FT RRWCDGDVDGRKLLPPARRTGTQQRRIRPAAPRVYTTGDILRDRKGIAPWQEQREPGWA FT PFGWLHEPSGARCPKADGQSV" FT CDS 136836..137618 FT /transl_table=11 FT /gene="cdh" FT /locus_tag="Rv2289" FT /product="Probable CDP-diacylglycerol pyrophosphatase Cdh FT (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol FT phosphatidylhydrolase)" FT /function="Involved in phospholipid biosynthesis [CATALYTIC FT ACTIVITY: CDP-diacylglycerol + H(2)O = CMP + FT phosphatidate]." FT /EC_number="3.6.1.26" FT /note="Rv2289, (MTCY339.21c), len: 260 aa. Probable cdh, FT CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26), similar FT to CDH_SALTY|P26219 cdp-diacylglycerol pyrophosphatase (251 FT aa), FASTA scores: opt: 395, E(): 5.9e-20, (33.5% identity FT in 221 aa overlap)." FT /db_xref="GOA:P63751" FT /db_xref="InterPro:IPR003763" FT /db_xref="UniProtKB/Swiss-Prot:P63751" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00999.1" FT /translation="MPKSRRAVSLSVLIGAVIAALAGALIAVTVPARPNRPEADREALW FT KIVHDRCEFGYRRTGAYAPCTFVDEQSGTALYKADFDPYQFLLIPLARITGIEDPALRE FT SAGRNYLYDAWAARFLVTARLNNSLPESDVVLTINPKNARTQDQLHIHISCSSPTTSAA FT LRNVDTSEYVGWKQLPIDLGGRRFQGLAVDTKAFESRNLFRDIYLKVTADGKKMENASI FT AVANVAQDQFLLLLAEGTEDQPVAAETLQDHDCSITKS" FT CDS 137760..138275 FT /transl_table=11 FT /gene="lppO" FT /locus_tag="Rv2290" FT /product="Probable conserved lipoprotein lppO" FT /function="UNKNOWN" FT /note="Rv2290, (MTCY339.20c), len: 171 aa. Probable lppO, FT conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 FT 19 kDa lipoprotein antigen precursor (159 aa) FASTA scores, FT opt: 119, E (): 1.3, (25.6% identity in 164 aa overlap). FT Contains appropriately positioned PS00013 lipoprotein motif FT (with one mismatch)." FT /db_xref="GOA:Q50675" FT /db_xref="UniProtKB/Swiss-Prot:Q50675" FT /protein_id="CAB01000.1" FT /translation="MTDPRHTVRIAVGATALGVSALGATLPACSAHSGPGSPPSAPSAP FT AAATVMVEGHTHTISGVVECRTSPAVRTATPSESGTQTTRVNAHDDSASVTLSLSDSTP FT PDVNGFGISLKIGSVDYQMPYQPVQSPTQVEATRQGKSYTLTGTGHAVIPGQTGMRELP FT FGVHVTCP" FT CDS 138335..139189 FT /transl_table=11 FT /gene="sseB" FT /locus_tag="Rv2291" FT /product="Probable thiosulfate sulfurtransferase SseB" FT /function="UNKNOWN" FT /EC_number="2.-.-.-" FT /note="Rv2291, (MTCY339.19c), len: 284 aa. Probable sseB, FT thiosulfate sulfurtransferase. Very similar to thiosulfate FT sulfurtransferas/rhodanese from Streptomyces coelicolor FT AL00920 4|SC9B10_21 (283 aa) opt: 765, E(): 0; FT Smith-Waterman score: 765; 46.9% identity in 286 aa FT overlap, similar to THTR_ECOLI P31142 putative thiosulfate FT sulfurtransferase (280 aa), FASTA scores, opt: 478, E(): FT 1e-23, (35.1% identity in 265 aa overlap)" FT /db_xref="GOA:Q59570" FT /db_xref="InterPro:IPR001763" FT /db_xref="UniProtKB/Swiss-Prot:Q59570" FT /protein_id="CAB00979.1" FT /translation="MQARGQVLITAAELAGMIQAGDPVSILDVRWRLDEPDGHAAYLQG FT HLPGAVFVSLEDELSDHTIAGRGRHPLPSGASLQATVRRCGIRHDVPVVVYDDWNRAGS FT ARAWWVLTAAGIANVRILDGGLPAWRSAGGSIETGQVSPQLGNVTVLHDDLYAGQRLTL FT TAQQAGAGGVTLLDARVPERFRGDVEPVDAVAGHIPGAINVPSGSVLADDGTFLGNGAL FT NALLSDHGIDHGGRVGVYCGSGVSAAVIVAALAVIGQDAELFPGSWSEWSSDPTRPVGR FT GTA" FT CDS complement(139190..139414) FT /transl_table=11 FT /locus_tag="Rv2292c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2292c, (MTCY339.18), len: 74 aa. Unknown FT hypothetical protein" FT /db_xref="GOA:P64977" FT /db_xref="InterPro:IPR000845" FT /db_xref="UniProtKB/Swiss-Prot:P64977" FT /protein_id="CAB00978.1" FT /translation="MNPGFDAVDQETAAAQAVADAHGVPFLGIRGMSDGPGDPLHLPGF FT PVQFFVYKQIAANNAARVTEAFLQNWAGV" FT CDS complement(139453..140193) FT /transl_table=11 FT /locus_tag="Rv2293c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2293c, (MTCY339.17), len: 246 aa. Conserved FT hypothetical protein; some similarity to hypothetical FT protein (299 aa) AAK24237.1| (AE005897) belonging to FT phosphorylase family [Caulobacter crescentus] (33% identity FT in 131 aa overlap). Possible lipoprotein: signal peptide at FT N-terminus" FT /db_xref="GOA:Q50673" FT /db_xref="InterPro:IPR018017" FT /db_xref="UniProtKB/Swiss-Prot:Q50673" FT /protein_id="CAB00977.1" FT /translation="MGAPLRHCLLVAAALSLGCGVAAADPGYVANVIPCEQRTLVLSAF FT PAEADAVLAHTALDANPVVVADRRRYYLGSISGKKVIVAMTGIGLVNATNTTETAFARF FT TCASSIAIAAVMFSGVAGGAGRTSIGDVAIPARWTLDNGATFRGVDPGMLATAQTLSVV FT LDNINTLGNPVCLCRNVPVVRLNHLGRQPQLFVGGDGSSSDKNNGQAFPCIPNGGSVFA FT ANPVVHPIAHLAIPVTFSRRRDPG" FT CDS 140488..141711 FT /transl_table=11 FT /locus_tag="Rv2294" FT /product="Probable aminotransferase" FT /function="UNKNOWN" FT /EC_number="2.6.1.-" FT /note="Rv2294, (MTCY339.16c), len: 407 aa. Probable FT aminotransferase (EC 2.6.1.-), similar to others in M. FT tuberculosis e.g. MTV030_19, also similar to FT PATB_BACSU|Q08432 putative aminotransferase b from Bacillus FT subtilis (387 aa), FASTA scores: opt: 563, E(): 2 .8e-29, FT (31.4% identity in 408 aa overlap); and to FT MALY_ECOLI|P23256 maly protein from Escherichia coli (390 FT aa), FASTA scores: opt: 530, E(): 3.6e-27, (31.3% identity FT in 384 aa overlap). BELONGS TO CLASS-II OF FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES." FT /db_xref="GOA:P63502" FT /db_xref="HSSP:1D2F" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P63502" FT /protein_id="CAB00976.1" FT /translation="MIPNPLEELTLEQLRSQRTSMKWRAHPADVLPLWVAEMDVKLPPT FT VADALRRAIDDGDTGYPYGTEYAEAVREFACQRWQWHDLEVSRTAIVPDVMLGIVEVLR FT LITDRGDPVIVNSPVYAPFYAFVSHDGRRVIPAPLRGDGRIDLDALQEAFSSARASSGS FT SGNVAYLLCNPHNPTGSVHTADELRGIAERAQRFGVRVVSDEIHAPLIPSGARFTPYLS FT VPGAENAFALMSASKAWNLGGLKAALAIAGREAAADLARMPEEVGHGPSHLGVIAHTAA FT FRTGGNWLDALLRGLDHNRTLLGALVDEHLPGVQYRWPQGTYLAWLDCRELGFDDAASD FT EMTEGLAVVSDLSGPARWFLDHARVALSSGHVFGIGGAGHVRINFATSRAILIEAVSRM FT SRSLLERR" FT CDS 141933..142571 FT /transl_table=11 FT /locus_tag="Rv2295" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2295, (MTCY339.15c), len: 212 aa. Conserved FT hypothetical protein, cysteine-rich protein, similar to FT YIEJ_ECOLI P31469 hypothetical 22.5 kDa protein in FT tnab-bglb intergenic region (195 aa), opt: 270, E(): FT 3.4e-11, (36.4% identity in 198 aa overlap). Alternative FT start suggested by similarity 26 codons further downstream" FT /db_xref="InterPro:IPR005363" FT /db_xref="UniProtKB/Swiss-Prot:P67309" FT /protein_id="CAB01001.1" FT /translation="MDQSANHACLPTPLASTTGRGQDHEMPVEETSTPQKLPQFRYHPD FT PVGTGSIVADEVSCVSCEQRRPYTYTGPVYAEEELNEAICPWCIADGSAASRFDATFTD FT AMWAVPDDVPEDVTEEVLCRTPGFTGWLQEEWLHHCGDAAAFLGPVGASEVADLPDALD FT ALRNEYRGYDWPADKIEEFILTLDRNGLATAYLFRCLSCGVHLAYADFA" FT CDS 142665..143567 FT /transl_table=11 FT /locus_tag="Rv2296" FT /product="Probable haloalkane dehalogenase" FT /function="Converts haloalkanes to corresponding alcohol FT and halides [CATALYTIC ACTIVITY: 1-haloalkane + H2O = a FT primary alcohol + halide]." FT /EC_number="3.8.1.5" FT /note="Rv2296, (MTCY339.14c), len: 300 aa. Probable FT haloalkane dehalogenase (EC 3.8.1.5), similar to e.g. FT HALO_XANAU P22643, haloalkane dehalogenase, (310 aa), opt: FT 510 z-score: 577.7 E(): 3.1e-25 (39.0% identity in 315 aa FT overlap)." FT /db_xref="GOA:P64301" FT /db_xref="HSSP:1HDE" FT /db_xref="InterPro:IPR000639" FT /db_xref="UniProtKB/Swiss-Prot:P64301" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00975.1" FT /translation="MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGD FT GPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKPTRIEDYTYLRHVEW FT VTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVANGFLPAAQGRTPLPFYV FT WRAFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDD FT PAVPANRAAWEALGRWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIKASHFI FT QEDSGTELAERMLSWQQAT" FT CDS 143599..144051 FT /transl_table=11 FT /locus_tag="Rv2297" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2297, (MTCY339.13c), len: 150 aa. Unknown protein; FT contains PS00343 Gram-positive cocci surface proteins FT 'anchoring' hexapeptide" FT /db_xref="UniProtKB/Swiss-Prot:P64979" FT /protein_id="CAB00974.1" FT /translation="MAMEMAMMGLLGTVVGASAMGIGGIAKSIAEAYVPGVAAAKDRRQ FT QMNVDLQARRYEAVRVWRSGLCSASNAYRQWEAGSRDTHAPNVVGDEWFEGLRPHLPTT FT GEAAKFRTAYEVRCDNPTLMVLSLEIGRIEKEWMVEASGRTPKHRG" FT misc_feature 143899..143916 FT /note="PS00343 Gram-positive cocci surface proteins FT 'anchoring' hexapeptide" FT CDS 144243..145214 FT /transl_table=11 FT /locus_tag="Rv2298" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2298, (MTCY339.12c), len: 323 aa. Conserved FT hypothetical protein. Similar to SLR0545 Synechocystis sp, FT Q55493 hypothetical 34.6 kDa protein (314 aa), FASTA FT scores, opt: 427, E(): 1.7e-20, (39.3% identity in 303 aa FT overlap) and to YZAE_BACSU P46905 hypothetical protein in FT natb 3'region (268 aa) FASTA scores, opt: 370, E(): FT 6.1e-17, (31.4% identity in 264 aa overlap)" FT /db_xref="GOA:P63484" FT /db_xref="HSSP:2ALR" FT /db_xref="InterPro:IPR001395" FT /db_xref="UniProtKB/Swiss-Prot:P63484" FT /protein_id="CAB00973.1" FT /translation="MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRA FT RALGVTLFDTAEIYGLGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERASAR FT RLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGR FT PVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALN FT PLFGTENLRRIEPLLATLRAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNV FT AAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR" FT CDS complement(145220..147163) FT /transl_table=11 FT /gene="htpG" FT /locus_tag="Rv2299c" FT /product="PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK FT PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN FT G)" FT /function="MOLECULAR CHAPERONE INVOLVED IN PROTEIN FOLDING. FT HAS ATPASE ACTIVITY." FT /note="Rv2299c, (MTCY339.11), len: 647 aa. htpG, probable FT chaperone, HSP90 familyHEAT SHOCK PROTEIN HSP90 FAMILY. FT Similar to HTPG_BACSU|P46208 heat shock protein htpG FT homologue from Bacillus subtilis (626 aa), FASTA scores: FT opt: 1551, E(): 0, (39.6% identity in 631 aa overlap). FT Contains possible helix-turn-helix motif at aa 519-540 FT (+3.77 SD). BELONGS TO THE HEAT SHOCK PROTEIN 90 FAMILY." FT /db_xref="GOA:P64411" FT /db_xref="HSSP:1YER" FT /db_xref="InterPro:IPR001404" FT /db_xref="UniProtKB/Swiss-Prot:P64411" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00972.1" FT /translation="MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALD FT KLRIEALRNKDLEVDTSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGTLAKSGTA FT ELRAQLREAKNAAASEELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGEGTY FT TIESVEDAPQGTSVTLHLKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRT FT PASQEEGGEGGEETVTIETETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEII FT AMKAEGTFEYQALLFIPSHAPFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKG FT VVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVL FT KEGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLK FT SPHLEAFKAKGYEVLLLTDPVDEVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAERE FT ERQKEFADLLTWLQETLSDHVKEVRLSTRLTESPACLITDAFGMTPALARIYRASGQEV FT PVGKRILELNPSHPLVTGLRQAHQDRADDAEKSLAETAELLYGTALLAEGGALEDPARF FT AELLAERLARTL" FT CDS complement(147237..148169) FT /transl_table=11 FT /locus_tag="Rv2300c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2300c, (MTCY339.09), len: 310 aa (start FT uncertain). Conserved hypothetical protein, similar to FT others e.g. Q9RXY2|DR0172 CONSERVED HYPOTHETICAL PROTEIN FT from Deinococcus radiodurans (271 aa), FASTA scores: opt: FT 306, E(): 1.3e-12, (34.6% identity in 229 aa overlap); FT Q9HZH1|PA3037 HYPOTHETICAL PROTEIN from Pseudomonas FT aeruginosa (288 aa), FASTA scores: opt: 248, E(): 7.9e-09, FT (31.5% identity in 238 aa overlap); Q9PDL8|XF1361 FT HYPOTHETICAL PROTEIN from Xylella fastidiosa (279 aa), FT FASTA scores: opt: 236, E(): 4.6e-08, (29.7% identity in FT 249 aa overlap); U70053|XCU70053_3 GumP PROTEIN from FT Xanthomonas campestris (282 aa), FASTA scores: opt: 222, FT E(): 3.7e-07, (30.1% identity in 248 aa overlap); etc." FT /db_xref="GOA:P64981" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/Swiss-Prot:P64981" FT /protein_id="CAB00971.1" FT /translation="MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPE FT AKGPPVKVHHLNCGTMNAFGIALLCHVLLVETDDGLVLVDTGFGIQDCLDPGRVGLFRH FT VLRPAFLQAETAARQIEQLGYRTSDVRHIVLTHFDFDHIGGIADFPEAHLHVTAAEARG FT AIHAPSLRERLRYRRGQWAHGPKLVEHGPDGEPWRGFASAKPLDSIGTGVVLVPMPGHT FT RGHAAVAVDAGHRWVLHCGDAFYHRGTLDGRFRVPFVMRAEEKLLSYNRNQLRDNQARI FT VELHRRHDPDLLIVCAHDPDLYQLARDTA" FT CDS 148176..148868 FT /transl_table=11 FT /gene="cut2" FT /locus_tag="Rv2301" FT /standard_name="cfp25" FT /product="PROBABLE CUTINASE CUT2" FT /function="HYDROLYSIS OF CUTIN (A POLYESTER THAT FORMS THE FT STRUCTURE OF PLANT CUTICLE)." FT /EC_number="3.1.1.-" FT /note="Rv2301, (MTCY339.08c), len: 230 aa. Probable cut2 FT (alternate gene name: cfp25), cutinase (EC 3.1.1.-), highly FT similar to others from Mycobacteria tuberculosis e.g. FT MTCY13E12.04|Rv3451|O06318|CUT3_MYCTU (247 aa), FASTA FT scores: opt: 569, E(): 2.3e-27, (45.3% identity in 223 aa FT overlap); MT2037|MTCY39.35|RV1984C|Q10837|CUT1_MYCTU (217 FT aa), FASTA scores: opt: 383, E(): 3.4e-16 (42.9% identity FT in 217 aa overlap); O69691|Rv3724|MTV025.072 PUTATIVE FT CUTINASE PRECURSOR (187 aa), FASTA scores: opt: 248, E(): FT 4.3e-08, (41.85% identity in 172 aa overlap); etc. Also FT similar to few others from other organisms e.g. Q9KK87 FT SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FT FASTA scores: opt: 391, E(): 1.1e-16, (39.15% identity in FT 235 aa overlap); etc. Contains PS00095 C-5 FT cytosine-specific DNA methylases C-terminal signature. FT BELONGS TO THE CUTINASE FAMILY. Start changed since first FT submission (+11 aa)." FT /db_xref="GOA:P63881" FT /db_xref="HSSP:1CUW" FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/Swiss-Prot:P63881" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00997.2" FT /translation="MNDLLTRRLLTMGAAAAMLAAVLLLTPITVPAGYPGAVAPATAAC FT PDAEVVFARGRFEPPGIGTVGNAFVSALRSKVNKNVGVYAVKYPADNQIDVGANDMSAH FT IQSMANSCPNTRLVPGGYSLGAAVTDVVLAVPTQMWGFTNPLPPGSDEHIAAVALFGNG FT SQWVGPITNFSPAYNDRTIELCHGDDPVCHPADPNTWEANWPQHLAGAYVSSGMVNQAA FT DFVAGKLQ" FT misc_feature 148362..148418 FT /note="PS00095 C-5 cytosine-specific DNA methylases FT C-terminal signature" FT CDS 148974..149216 FT /transl_table=11 FT /locus_tag="Rv2302" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2302, (MTCY339.07c), len: 80 aa. Conserved FT hypothetical protein, highly similar to others: FT O53766|AL021942|Rv0569|MTV039.07 HYPOTHETICAL 9.5 KDA FT PROTEIN from Mycobacterium tuberculosis (88 aa), FASTA FT scores: opt: 300, E(): 1.4e-14, (61.85% identity in 76 aa FT overlap); O88049|SCI35.11 HYPOTHETICAL 7.1 KDA PROTEIN from FT Streptomyces coelicolor (64 aa), FASTA scores: opt: 169, FT E(): 1.5e-05, (46.55% identity in 58 aa overlap) (has its FT C-terminus shorter); Q9XCD1 HYPOTHETICAL 12.0 KDA PROTEIN FT (FRAGMENT) from Thermomonospora fusca (106 aa), FASTA FT scores: opt: 126, E(): 0.023, (50.0% identity in 34 aa FT overlap) (similarity in part for this one). Also weakly FT similar to U650M|G699303|Q50105 HYPOTHETICAL 5.7 KDA FT PROTEIN from Mycobacterium leprae (53 aa), FASTA scores: FT opt: 89, E(): 0.66, (45.5% identity in 33 aa overlap); and FT weakly similar to N-terminus of Q9RIZ1|SCJ1.23c putative FT DNA-binding protein from Streptomyces coelicolor (323 aa), FT FASTA scores: opt: 182, E(): 7.3e-06, (42.25% identity in FT 71 aa overlap)." FT /db_xref="InterPro:IPR015035" FT /db_xref="PDB:2A7Y" FT /db_xref="UniProtKB/Swiss-Prot:P64983" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00996.1" FT /translation="MHAKVGDYLVVKGTTTERHDQHAEIIEVRSADGSPPYVVRWLVNG FT HETTVYPGSDAVVVTATEHAEAEKRAAARAGHAAT" FT CDS complement(149257..150180) FT /transl_table=11 FT /locus_tag="Rv2303c" FT /product="PROBABLE ANTIBIOTIC-RESISTANCE PROTEIN" FT /function="COULD BE INVOLVED IN ANTIBIOTIC-RESISTANCE." FT /note="Rv2303c, (MTCY339.06, MT2360), len: 307 aa. Probable FT antibiotic-resistance protein, with some similarity to FT Q54229|G153373 macrotetrolide antibiotic-resistance protein FT (NONR) from Streptomyces griseus (347 aa) (see the first FT citation below), FASTA scores: opt: 438, E(): 3.1e-21, FT (33.2% identity in 226 aa overlap); and other hypothetical FT proteins e.g. P95886 ORF C02006 from Sulfolobus FT solfataricus (269 aa), FASTA scores: opt: 252, E(): FT 3.5e-09, (25.5% identity in 286 aa overlap); etc. Also FT similar to Mycobacterium tuberculosis FT Rv3510c|O53555|MTV023.17. Note that the protein Q9XDF3|NONC FT from Streptomyces griseus subsp. griseus (317 aa) is FT equivalent to Q54229|G153373|NONR however the N-terminal FT end is shorter (30 aa) owing to a changed start codon (see FT the second citation below)." FT /db_xref="GOA:Q50662" FT /db_xref="InterPro:IPR006992" FT /db_xref="UniProtKB/TrEMBL:Q50662" FT /protein_id="CAB00995.1" FT /translation="MTAPEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKT FT TISAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFVHNASVAAVAA FT RYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRPFMIGRPASDPAYFPCYAKC FT VELGVPVSIHTSADWTRTRLSDLGHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAW FT KHPNVYLELAAHRPKYFASPGAGWEPLMRFGQTTIRNKIVYGTGGFLINRPYLQLCDEM FT RALPVPREVLEDWLWRNATRVLRLDT" FT CDS complement(150177..150386) FT /transl_table=11 FT /locus_tag="Rv2304c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2304c, (MTCY339.05), len: 69 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64985" FT /protein_id="CAB00994.1" FT /translation="MSHDIATEEADDGALDRCVLCDLTGKRVDVKEATCTGRPATTFEQ FT AFAVERDAGFDDFLHGPVGPRSTP" FT CDS 150970..152259 FT /transl_table=11 FT /locus_tag="Rv2305" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2305, (MTCY339.04c), len: 429 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR001242" FT /db_xref="UniProtKB/Swiss-Prot:Q50660" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00993.1" FT /translation="MTQTLRLTALDEMFITDDIDIVPSVQIEARVSGRFDLDRLAAALR FT AAVAKHALARARLGRASLTARTLYWEVPDRADHLAVEITDEPVGEVRSRFYARAPELHR FT SPVFAVAVVRETVGDRLLLNFHHAAFDGMGGLRLLLSLARAYAGEPDEVGGPPIEEARN FT LKGVAGSRDLFDVLIRARGLAKPAIDRKRTTRVAPDGGSPDGPRFVFAPLTIESDEMAT FT AVARRPEGATVNDLAMAALALTILQWNRTHDVPAADSVSVNMPVNFRPTAWSTEVISNF FT ASYLAIVLRVDEVTDLEKATAIVAGITGPLKQSGAAGWVVDLLEGGKVLPAMLKRQLQL FT LLPLVEDRFVESVCLSNLGRVDVPAFGGEAGDTTEVWFSPTAAMSVMPIGVGLVGFGGT FT LRAMFRGDGRTIGGEALGRFAALYRDTLLT" FT CDS 152269..152862 FT /transl_table=11 FT /locus_tag="Rv2306A" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2306A, len: 197 aa. Possible conserved membrane FT protein, similar to several hypothetical membrane proteins FT from Mycobacterium tuberculosis and Streptomyces FT coelicolor, e.g. Rv0625c|P96915|Y625_MYCTU HYPOTHETICAL FT 25.2 KDA PROTEIN from Mycobacterium tuberculosis (246 aa), FT FASTA scores: opt: 410, E(): 2.7e-17, (53.25% identity in FT 139 aa overlap). First 140 aa show high similarity, this FT then decreases but continues in next ORF Rv2306B, FT suggesting a frameshift near nt 2577473. However the FT sequence has been checked and no error found. The sequence FT is identical in CDC1551 and Mycobacterium bovis. Replaces FT original Rv2306c on other strand." FT /db_xref="UniProtKB/TrEMBL:Q79FG5" FT /protein_id="CAE55465.1" FT /translation="MTDNECPADSRRRHVLRLALFAGILLGLFYLVAVARVIHVDGVRS FT AIVVATGPIAPLAYVVVSAALGALFVPGPILAAGSGVLFGPLLDTFVTLPAFSAGAQAG FT MTPRRCWVSIAPIASMHRSNGADCGRWSVSASSPASRMRWPRTPSGRSEFRCGRWSLGR FT SSGRRHGCSSTPRWARRSPTCRRRWFTRRSRCGA" FT CDS 152649..153083 FT /transl_table=11 FT /locus_tag="Rv2306B" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2306B, len: 144 aa. Possible conserved membrane FT protein, similar to C-terminal part of several hypothetical FT membrane proteins from Mycobacterium tuberculosis and FT Streptomyces coelicolor e.g. P96915|Y625_MYCTU|RV0625c FT HYPOTHETICAL 25.2 KDA PROTEIN from Mycobacterium FT tuberculosis (246 aa), FASTA scores: opt: 480, E(): 5e-24, FT (77.15% identity in 92 aa overlap). Could be a continuation FT of Rv2306A suggesting there may be a frameshift near nt FT 2577473. The C-terminal part is longer than Rv0625c and the FT 3'-end of gene overlaps Rv2307c, so maybe a further FT framehift. However, sequence has been checked and no error FT found. Also same sequence as strain CDC1551 and FT Mycobacterium bovis. Replaces original Rv2306c on other FT strand." FT /db_xref="InterPro:IPR015414" FT /db_xref="UniProtKB/TrEMBL:Q79FG4" FT /protein_id="CAE55466.1" FT /translation="MWAVVGQRFVPGISDALASYTFGAFGVPLWQMVVGSFIGSAPRVF FT VYTALGASITNLSSPLVYSAIAVWCVTAIIGAFAARRWYRKWRARPRRRCGLAQLTTGS FT QQRHTSHRTPAGVVMPGSLSEHRRLRQEAPDRIEHHPPIE" FT CDS complement(153012..153857) FT /transl_table=11 FT /locus_tag="Rv2307c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2307c, (MTCY339.02), len: 281 aa. Conserved FT hypothetical protein, similar to many other hypothetical FT proteins and BEM1/BUD5 suppressors e.g. P77538 HYPOTHETICAL FT PROTEIN from Escherichia coli (293 aa), FASTA scores: opt: FT 421, E(): 2.4e-18, (32.1% identity in 268 aa overlap) FT (alias AAG57647|Z3802|BAB36823|ECS3400 Putative enzyme FT (3.4.-) from Escherichia coli (293 aa), FASTA scores: opt: FT 425, E(): 1.7e-18, (32.1% identity in 268 aa FT overlap));P54069|BE46_SCHPO|BEM46|SPBC32H8.03|PI020 BEM46 FT PROTEIN from Schizosaccharomyces pombe (Fission yeast) (352 FT aa), FASTA scores: opt: 355, E(): 3.3e-14, (30.45% identity FT in 279 aa overlap); O76462|BEM46 BEM46 PROTEIN from FT Drosophila melanogaster (338 aa), FASTA scores: opt: 404, FT E(): 2.8e-17, (32.75% identity in 281 aa overlap); etc. FT Equivalent (but with few differences) to AAK46650|MT2364 FT protein from Mycobacterium tuberculosis strain CDC1551 (281 FT aa)." FT /db_xref="GOA:Q50658" FT /db_xref="UniProtKB/Swiss-Prot:Q50658" FT /protein_id="CAB00991.1" FT /translation="MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSA FT SSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGL FT GLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAV FT GLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAG FT GSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ FT " FT CDS complement(154389..154580) FT /transl_table=11 FT /locus_tag="Rv2307A" FT /product="HYPOTHETICAL GLYCINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2307A, len: 63 aa. Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q8VJM8" FT /protein_id="CAE55467.1" FT /translation="MAFVDLRYPWCRGDGWISPPVVAVALGWAMRRKPFSRFNEYVGSA FT SNTCWFARALELRTLLIR" FT CDS complement(154665..155096) FT /transl_table=11 FT /locus_tag="Rv2307B" FT /product="HYPOTHETICAL GLYCINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv2307B, len: 143 aa. Hypothetical unknown Gly- rich FT protein. Equivalent to AAK46653 from Mycobacterium FT tuberculosis strain CDC1551 (133 aa) but longer 10 aa." FT /db_xref="UniProtKB/TrEMBL:Q79FG2" FT /protein_id="CAE55468.1" FT /translation="MEEVPTGPPAMGHRACGGQKAAFPTRMNSGVEKMYKNSIAIAIGT FT LTMAVEFSMVSANAEPAPPPGQDPHMPNSAMGYCPGGGFGGITGWGYCDGIRYPDGSYW FT HQVRVPAPFVGTTLTLSCVIDDGSPVPPLAAPGSCGGGA" FT CDS complement(155189..155371) FT /transl_table=11 FT /locus_tag="Rv2307D" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2307D, len: 60 aa. Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q8VJM6" FT /protein_id="CAE55469.1" FT /translation="MWRHLWLMQPQRRYPRGSGTTRTARRDAGVAPLYGVSRVTVLAST FT TATTAPPVKSFPDLL" FT CDS 155580..156296 FT /transl_table=11 FT /locus_tag="Rv2308" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2308, (MTCY339.01c), len: 238 aa. Conserved FT hypothetical protein, sharing similarity with FT O53464|Rv2018|MTV018.05 from Mycobacterium tuberculosis FT (239 aa), FASTA scores: opt: 142, E(): 0.034, (24.8% FT identity in 250 aa overlap). As contains possible FT helix-turn-helix motif at aa 16-37 (Sequence: FT YVYAEVDKLIGLPAGTAKRWIN) (Score 1169, +3.17 SD), may be a FT transcriptional regulator." FT /db_xref="InterPro:IPR017277" FT /db_xref="UniProtKB/Swiss-Prot:Q50657" FT /protein_id="CAB00990.1" FT /translation="MRADMSVTSMLDREVYVYAEVDKLIGLPAGTAKRWINGYERGGKD FT HPPILRVTPGATPWVTWGEFVETRMLAEYRDRRKVPIVRQRAAIEELRARFNLRYPLAH FT LRPFLSTHERDLTMGGEEIGLPDAEVTIRTGQALLGDARWLASIATPGRDEVGEAVIVE FT LPVDKAFPEIVINPSRYSGQPTFVGRRVSPVTIAQMVDGGEEREDLAADYGLSLKQIQD FT AIDYTKKYRLARLVAA" FT tRNA complement(156925..156998) FT /gene="tRNA-Met(CAT)" FT /product="transfer RNA-Met(CAT)" FT /anticodon=(pos:156962..156964,aa:Met) FT CDS complement(157004..157459) FT /transl_table=11 FT /locus_tag="Rv2309c" FT /product="POSSIBLE INTEGRASE (FRAGMENT)" FT /function="USE FOR SEQUENCE INTEGRATION. INTEGRASE IS FT NECESSARY FOR INTEGRATION OF A PHAGE INTO THE HOST GENOME FT BY SITE-SPECIFIC RECOMBINATION. IN CONJUNCTION WITH FT EXCISIONASE, INTEGRASE IS ALSO NECESSARY FOR EXCISION OF FT THE PROPHAGE FROM THE HOST GENOME (BY SIMILARITY)." FT /note="Rv2309c, (MTCY3G12.25), len: 151 aa. Possible FT integrase (fragment), similar to others e.g. Q48908 FT INTEGRASE (FRAGMENT) from Mycobacterium paratuberculos (191 FT aa), FASTA scores: opt: 279, E(): 3.2e-11, (40.4% identity FT in 136 aa overlap); etc. Also similar to others from FT Mycobacterium tuberculosis e.g. Rv1055|MTV017.08 INTEGRASE FT (FRAGMENT) (78 aa) (72.85% identity in 70 aa overlap); and FT Rv1054|MTV017.07 INTEGRASE (FRAGMENT). COULD BELONG TO THE FT 'PHAGE' INTEGRASE FAMILY." FT /db_xref="GOA:P71903" FT /db_xref="HSSP:1AIH" FT /db_xref="InterPro:IPR014417" FT /db_xref="UniProtKB/TrEMBL:P71903" FT /protein_id="CAB02057.1" FT /translation="MTGAGIVETTTNRVRHVPVPEPVSERLRDELPTEPNALVFPSYRG FT GHLPIEEYRRAFDKGCKAVGIADLVPHGLRHTTASLAISAGANVKVVQRLLGHATAAMT FT LDRHGHLLSDDLAGVAGLLVQAIKSAAASLRYSDPDSVAVENISAAS" FT CDS 158206..158493 FT /transl_table=11 FT /locus_tag="Rv2309A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2309A, len: 95 aa. Hypothetical unknown protein. FT Equivalent to AAK46663 from Mycobacterium tuberculosis FT strain CDC1551 (95 aa) but longer 13 aa." FT /db_xref="UniProtKB/TrEMBL:Q8VJL9" FT /protein_id="CAE55470.1" FT /translation="MATSSDDITINRHPPLNCAVNRHDESRRSPLRRGLLANGLRERQA FT GALFERYESQFDSFGYIEKVRYRGSGYRVEDVYARADSGPSAGAELPVGP" FT CDS 158596..158940 FT /transl_table=11 FT /locus_tag="Rv2310" FT /product="POSSIBLE EXCISIONASE" FT /function="USE FOR SEQUENCE EXCISION." FT /note="Rv2310, (MT2372, MTCY3G12.24c), len: 148 aa. FT Possible excisionase, showing some similarity to others FT e.g. Q9LCU5 PUTATIVE EXCISIONASE from Arthrobacter sp. TM1 FT (174 aa) FASTA scores: opt: 341, E(): 6.6e-15, (48.2% FT identity in 110 aa overlap); O85865 PUTATIVE EXCISIONASE FT from Sphingomonas aromaticivorans (152 aa), FASTA scores: FT opt: 205, E(): 2.2e-06, (41.25% identity in 80 aa overlap); FT etc. Also similar to Rv3750c|O69717 HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (130 aa), FASTA scores: FT opt: 228, E(): 6.9e-08, (43.9% identity in 82 aa overlap). FT Contains possible helix-turn-helix motif at aa 20-41 (Score FT 2181, +6.62 SD)." FT /db_xref="GOA:P64987" FT /db_xref="InterPro:IPR010093" FT /db_xref="UniProtKB/Swiss-Prot:P64987" FT /protein_id="CAB02074.1" FT /translation="MVAALHAGKAVTIAPQSMTLTTQQAADLLGVSRPTVVRLIKSGEL FT AAERIGNRHRLVLDDVLAYREARRQRQYDALAESAMDIDADEDPEVICEQLREARRVVA FT ARRRTERRRA" FT CDS 159045..159569 FT /transl_table=11 FT /locus_tag="Rv2311" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2311, (MTCY3G12.23c), len: 174 aa. Conserved FT hypothetical protein, with similarity (in part) to transfer FT proteins homologous TRAA e.g. Q9EUN8|TRAA TRANSFER PROTEIN FT HOMOLOG TRAA from Corynebacterium glutamicum (1160 aa), FT FASTA scores: opt: 221, E(): 2.9e-07, (36.8% identity in FT 136 aa overlap); Q9ETQ3|TRAA CONJUGAL TRANSFER PROTEIN FT (TRAA-LIKE PROTEIN) from Corynebacterium equii (1367 aa), FT FASTA scores: opt: 188, E(): 5.5e-05, (33% identity in 106 FT aa overlap); P55418|TRAA_RHISN|Y4DS PROBABLE CONJUGAL FT TRANSFER PROTEIN from Rhizobium sp. strain NGR234 (1102 FT aa), FASTA scores: opt: 145, E(): 0.035, (29.08% identity FT in 141 aa overlap); etc." FT /db_xref="UniProtKB/Swiss-Prot:P64989" FT /protein_id="CAB02056.1" FT /translation="MAPTGQAVDVAVREGAGDVGYSVERENLPADDPVRNGNRWRVIAV FT DTEHHRIAARRLGDGARAAFSGDYLHEHITHGYAITVHASQGTTAHSTHAVLGDNTSRA FT TLYVAMTPARESNTAYLCERTAGEGARVDLAGWDLWVSGKAEAMSDEKSASPVWCRVGA FT RCDHRGKRSCW" FT CDS 159647..159916 FT /transl_table=11 FT /locus_tag="Rv2312" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2312, (MTCY3G12.22c), len: 89 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64991" FT /protein_id="CAB02055.1" FT /translation="MMKEIELHLVDAAAPSGEIAIKDLAALATALQELTTRISRDPINT FT PGPGRTKQFMEELSQLASAPGPDIDGGIDLTDDEFQAFLQAARS" FT CDS complement(160213..161067) FT /transl_table=11 FT /locus_tag="Rv2313c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2313c, (MTCY3G12.21), len: 284 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64993" FT /protein_id="CAB02054.1" FT /translation="MPAPVSVRDDLCRLVALSPGDGRIAGLVRQVCARALSLPSLPCEV FT AVNEPESPAEAVVAEFAEQFSVDVSAITGEQRSLLWTHLGEDAFGAVVAMYIADFVPRV FT RAGLEALGVGKEYLGWVTGPISWDHNTDLSAAVFNGFLPAVARMRALDPVTSELVRLRG FT AAQHNCRVCKSLREVSALDAGGSETLYGEIERFDTSVLLDVRAKAALRYADALIWTPAH FT LAVDVAVEVRSRFSDDEAVELTFDIMRNASNKVAVSLGADAPRVQQGTERYRIGLDGQT FT VFG" FT CDS complement(161078..162451) FT /transl_table=11 FT /locus_tag="Rv2314c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2314c, (MTCY3G12.20), len: 457 aa. Conserved FT hypothetical protein, highly similar to Q9RJ51|SCI8.02 FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (464 aa) FT FASTA scores: opt: 1485, E(): 5.2e-83, (53.5% identity in FT 454 aa overlap); similar to AAK24788|CC2824 TldD/PmbA FT family protein from Caulobacter crescentus (441 aa), FASTA FT scores: opt: 364, E(): 8.3e-15, (29.8% identity in 460 aa FT overlap); and showing similarity with Q9HJZ6|TA0814 FT HYPOTHETICAL PROTEIN from Thermoplasma acidophilum (430 FT aa), FASTA scores: opt: 220, E(): 4.7e-06, (21.85% identity FT in 348 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P71898" FT /protein_id="CAB02053.1" FT /translation="MIEPQHAVNIVLKEAARSGRADETMVLVTEKVEATLRWAGNSMTT FT NGVSHSRNVTVISIVRRGDSAFVGSVVSAEVDPSVLPGLVVSSQDAARSAPEAGDAAPL FT LADTGEPDDWDAPVPGTGAGVFTGIAGSLSRGFRGADRLYGYAHRSVSTTFLASSTGLR FT RRYTQPTGAIEINAKRGDASAWVGIGTPDFVEVPIDLMLERLSTRLRWAQRTVELPAGR FT YQTIMPPSTVADMMIYLGWSMAGRGAQEGRTAFSAPGGGTRVGERLTELPLTLFTDPAA FT PGLACTPFVAVSNSSETQSVFDNGMEISQVDWIRSGVINALAYPRATAAKFDAPVAVAA FT DNLIMTGGSADLADMIAGTERGLLLTTLWYIREVDPTTLLLTGLTRDGVYLVEDGEVSA FT AVNNFRFNESPLDLLRRATEAGVSEPTLPREWSDWVTRTAMPPLRIPDFHMSSVSQAQ" FT CDS complement(162448..163965) FT /transl_table=11 FT /locus_tag="Rv2315c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved FT hypothetical protein, highly similar to Q9S273|SCI28.10 FT HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor FT (435 aa), FASTA scores: opt: 1768, E():5.6e-101, (63.2% FT identity in 432 overlap); and similar to others e.g. FT AAK24787|CC2823 hypothetical protein (TldD/PmbA family) FT from Caulobacter crescentus (543 aa), FASTA scores: opt: FT 876, E():3.1e-46, (42.8% identity in 505 overlap); FT O58578|PH0848 HYPOTHETICAL 54.4 KDA PROTEIN from Pyrococcus FT horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, FT (29.95% identity in 484 aa overlap); Q9UZ95|PAB1547 FT HYPOTHETICAL 53.6 KDA PROTEIN from Pyrococcus abyssi (473 FT aa), FASTA scores: opt: 656, E(): 8.6e-33, (29.1% identity FT in 481 aa overlap); etc." FT /db_xref="InterPro:IPR002510" FT /db_xref="UniProtKB/TrEMBL:P71897" FT /protein_id="CAB02052.1" FT /translation="MTPNRGIDEDFLDLPRQQLADAALSAAATAGASHADLRVHRISTE FT IIQLRDGELETAVISRELGLAVRVIVAGTWGFASHAELAPDVAAATARHAVHVATVLAA FT LNTERVRLAPEPVYTDAEWVSNYRIDPFGVPASEKIAVLRDYSGRLLDADGIDHVSASL FT NAVKEQTFYADTFGSSITQQRVRLLPCLDAVAVDSAAGNFESMRTLAPPTARGWEVVAG FT DEIWNWTDELAQLPSLLAEKVRAPSVMPGPTDLVIDPTNLWLTIHESIGHATEYDRAIG FT YEAAYAGTSFATPDKLGTLRYGSPVMNVTADRTAEFGLATVGYDDEGVAAQSWDLVRDG FT VFVGYQLDRAFAPRLGEPRSNGCSYADSPHHVPIQRMANISLQPGIEDLSTADLIGRVD FT DGIYIVGDKSWSIDMQRYNFQFTGQRFFRIRGGQLYGQLRDVAYQSSTTDFWNAMEAVG FT GPSTWRMGGAINCGKAQPGQVAAVSHGCPSALFRGVNVLNTRTEGGR" FT CDS 163999..164871 FT /transl_table=11 FT /gene="uspA" FT /locus_tag="Rv2316" FT /product="PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER USPA" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT SUGAR ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2316, (MTCY3G12.18c), len: 290 aa. Probable uspA, FT sugar-transport integral membrane protein ABC transporter FT (see citation below), most similar to Q9CBN8|USPA|ML1768 FT SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from FT Mycobacterium leprae (328 aa), FASTA scores: opt: 1593, FT E(): 1.9e-93, (82.35% identity in 289 aa overlap); and FT similar to O32940|ML1426|MLCB2052.28 POSSIBLE SUGAR FT TRANSPORT PROTEIN (PROBABLE ABC-TRANSPORT PROTEIN, INNER FT MEMBRANE COMPONENT) from Mycobacterium leprae (319 aa), FT FASTA scores: opt: 600, E(): 9.2e-31, (34.25% identity in FT 295 aa overlap). Also similar to other proteins involved in FT transport e.g. Q9X860|SCE134.05c PUTATIVE BINDING PROTEIN FT DEPENDENT TRANSPORT PROTEIN from Streptomyces coelicolor FT (327 aa), FASTA scores: opt: 639, E(): 3.2e-33, (40.45% FT identity in 272 aa overlap); Q9K6N9|BH3689 SUGAR TRANSPORT FT SYSTEM (PERMEASE) from Bacillus halodurans (300 aa), FASTA FT scores: opt: 590, E(): 3.7e-30, (35.65% identity in 289 aa FT overlap); etc." FT /db_xref="GOA:P71896" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:P71896" FT /protein_id="CAB02051.1" FT /translation="MRDAPRRRTALAYALLAPSLVGVVAFLLLPILVVVWLSLHRWDLL FT GPLRYVGLTNWRSVLTDSGFADSLVVTAVFVAIVVPAQTVLGLLAASLLARRLPGTGLF FT RTLYVLPWICAPLAIAVMWRWIVAPTDGAISTVLGHRIEWLTDPGLALPVVSAVVVWTN FT VGYVSLFFLAGLMAIPQDIHNAARTDGASAWQRFWRITLPMLRPTMFFVLVTGIISAAQ FT VFDTVYALTGGGPQGSTDLVAHRIYAEAFGAAAIGRASVMAVVLFVILVGATVVQHLYF FT RRRISYELT" FT CDS 164858..165682 FT /transl_table=11 FT /gene="uspB" FT /locus_tag="Rv2317" FT /product="PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER USPB" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT SUGAR ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2317, (MTC3G12.17c), len: 274 aa. Probable uspB, FT sugar-transport integral membrane protein ABC transporter FT (see citation below), most similar to Q9CBN7|USPE|ML1769 FT SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from FT Mycobacterium leprae (274 aa), FASTA scores: opt: 1522, FT E(): 3.4e-89, (85.0% identity in 274 aa overlap); and FT similar to O32941|ML1425|MLCB2052.29 PROBABLE ABC-TRANSPORT FT PROTEIN, INNER MEMBRANE COMPONENT from Mycobacterium leprae FT (283 aa), FASTA scores: opt: 630, E(): 8.4e-33, (36.55% FT identity in 268 aa overlap). Also similar to other integral FT membrane proteins e.g. P73854|LACG|SLR1723 LACTOSE FT TRANSPORT SYSTEM PERMEASE PROTEIN from Synechocystis sp. FT strain PCC 6803 (270 aa), FASTA scores: opt: 605, E(): FT 3.1e-31, (36.0% identity in 264 aa overlap); FT Q9F3B8|SC5F1.11 PUTATIVE SUGAR TRANSPORT INTEGRAL MEMBRANE FT PROTEIN from Streptomyces coelicolor (307 aa), FASTA FT scores: opt: 582, E(): 9.7e-30, (34.45% identity in 264 aa FT overlap); etc. Also similar to O53483|Rv2039c|MTV018.26c FT SUGAR TRANSPORT PROTEIN from Mycobacterium tuberculosis FT (280 aa), FASTA scores: opt: 630, E(): 8.3e-89, (37.7% FT identity in 268 aa overlap)." FT /db_xref="GOA:Q7D7B8" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q7D7B8" FT /protein_id="CAE55471.1" FT /translation="MSSPSRVSNTAVYAVLTIGAVITLSPFLLGLLTSFTSAHQFATGT FT PLQLPRPPTLANYADIADAGFRRAAVVTALMTAVILLGQLTFSVLAAYAFARLQFRGRD FT ALFWVYVATLMVPGTVTVVPLYLMMAQLGLRNTFWALVLPFMFGSPYAIFLLREHFRLI FT PDDLINAARLDGANTLDVIVHVVIPSSRPVLAALAMITVVSQWNNFMWPLVITSGHKWR FT VLTVATADLQSRFNDQWTLVMAATTVAIVPLIALFVTFQRHIVASIVVSGLK" FT CDS 165679..167001 FT /transl_table=11 FT /gene="uspC" FT /locus_tag="Rv2318" FT /product="PROBABLE PERIPLASMIC SUGAR-BINDING LIPOPROTEIN FT USPC" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT SUGAR ACROSS THE MEMBRANE (IMPORT)." FT /note="Rv2318, (MTCY3G12.16c), len: 440 aa. Probable uspC, FT sugar-binding lipoprotein component of sugar transport FT system (see citation below), most similar to FT Q9CBN6|USPC|ML1770 SUGAR TRANSPORT PERIPLASMIC BINDING FT PROTEIN from Mycobacterium leprae (446 aa), FASTA scores: FT opt: 2294, E(): 8.1e-135, (74.7% identity in 446 aa FT overlap). Also similar to other substrate-binding proteins FT e.g. Q9RK89|SCF1.15 PUTATIVE SUBSTRATE BINDING PROTEIN FT (EXTRACELLULAR) (BINDING-PROTEIN-DEPENDENT TRANSPORT) FT (FRAGMENT) from Streptomyces coelicolor (221 aa), FASTA FT scores: opt: 377, E(): 3e-16, (32.25% identity in 217 aa FT overlap); Q9K6N8|BH3690 SUGAR TRANSPORT SYSTEM FT (SUGAR-BINDING PROTEIN) from Bacillus halodurans (420 aa), FT FASTA scores: opt: 227, E(): 1e-06, (25.00% identity in 452 FT aa overlap); etc. Also similar to O53485|Rv2041c|MTV018.28C FT LIPOPROTEIN COMPONENT OF SUGAR TRANSPORT SYSTEM from FT Mycobacterium tuberculosis (439 aa), FASTA scores: opt: FT 246, E(): 7e-08, (26.75% identity in 325 aa overlap). FT Contains a hydrophobic stretch (possible signal peptide) at FT N-terminal end." FT /db_xref="GOA:P71894" FT /db_xref="InterPro:IPR006059" FT /db_xref="UniProtKB/TrEMBL:P71894" FT /protein_id="CAB02072.1" FT /translation="MTRPRQSTLVATALVLVAILLGVTAVLLGLSAEPRGGKIVVTVRL FT WDEPIAAAYRQSFAAFTRSHPDIEVRTNLVAYSTYFETLRTDVAGGSADDIFWLSNAYF FT AAYADSGRLMKIQTDAADWEPAVVDQFTRSGVLWGVPQLTDAGIAVFYNADLLAAAGVD FT PTQVDNLRWSRGDDDTLRPMLARLTVDADGRTANTPGFDARRVRQWGYNAANDPQAIYL FT NYIGSAGGVFQRDGKFAFDNPGAIEAFRYLVGLINDDHVAPPASDTNDNGDFSRNQFLA FT GKMALFQSGTYSLAPVARDALFHWGVAMLPAGPAGRVSVTNGIAAAGNSASKHPDAVRQ FT VLAWMGSTEGNSYLGRHGAAIPAVLSAQPVYFDYWSARGVDVTPFFAVLNGPRIAAPGG FT AGFAAGQQALEPYFDEMFLGRGDVTTTLRQAQAAANAATQR" FT CDS complement(167009..167887) FT /transl_table=11 FT /locus_tag="Rv2319c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2319c, (MTCY3G12.15), len: 292 aa. Hypothetical FT unknown protein." FT /db_xref="GOA:P64995" FT /db_xref="InterPro:IPR006016" FT /db_xref="UniProtKB/Swiss-Prot:P64995" FT /protein_id="CAB02071.1" FT /translation="MTIVVGYLAGKVGPSALHLAVRVARMHKTSLTVATIVRRHWPTPS FT LARVDAEYELWSEQLAAASAREAQRYLRRLADGIEVSYHHRAHRSVSAGLLDVVEELEA FT EVLVLGSFPSGRRARVLIGSTADRLLHSSPVPVAITPRRYRCYTDRLTRLSCGYSATSG FT SVDVVRRCGHLASRYGVPMRVITFAVRGRTMYPPEVGLHAEASVLEAWAAQARELLEKL FT RINGVVSEDVVLQVVTGNGWAQALDAADWQDGEILALGTSPFGDVARVFLGSWSGKIIR FT YSPVPVLVLPG" FT CDS complement(167884..169314) FT /transl_table=11 FT /gene="rocE" FT /locus_tag="Rv2320c" FT /product="PROBABLE CATIONIC AMINO ACID TRANSPORT INTEGRAL FT MEMBRANE PROTEIN ROCE" FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF CATIONIC FT AMINO ACID (ESPECIALLY ARGININE AND ORNITHINE) ACROSS THE FT MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2320c, (MTCY3G12.14), len: 476 aa. Probable rocE, FT cationic amino acid (especially arginine and ornithine) FT transporter (permease), highly similar to other amino acid FT transporters e.g. Q9L100|SCL6.16C PUTATIVE AMINO ACID FT TRANSPORTER from Streptomyces coelicolor (496 aa), FASTA FT scores: opt: 1485, E(): 9.4e-82, (48.4% identity in 477 aa FT overlap); O06479|YFNA PUTATIVE AMINO ACID TRANSPORTER from FT Bacillus subtilis (462 aa), FASTA scores: opt: 1271, E(): FT 6.1e-69, (41.9% identity in 463 aa overlap); Q9PG94|XF0408 FT AMINO ACID TRANSPORTER from Xylella fastidiosa (509 aa), FT FASTA scores: opt: 1128, E(): 2.5e-60, (39.5% identity in FT 481 aa overlap); etc. Also some similarity with FT Z99108.1|BSUB0005 from Bacillus subtilis (461 aa), FASTA FT scores: opt: 1271, E(): 0, (41.9% identity in 463 aa FT overlap); and G403170 ETHANOLAMINE PERMEASE (488 aa), FASTA FT scores: opt: 468, E(): 1e-23, (28.1% identity in 462 aa FT overlap). SEEMS TO BELONG TO THE APC FAMILY." FT /db_xref="GOA:P71892" FT /db_xref="InterPro:IPR002293" FT /db_xref="UniProtKB/TrEMBL:P71892" FT /protein_id="CAB02070.1" FT /translation="MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTFQLTMFGV FT GATIGTGIFFVLAQAVPEAGPGVIVSFIIAGIAAGLAAICYAELASAVPISGSAYSYAY FT TTLGEAVAMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHP FT GWVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSADHLKDF FT VPFGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVAL FT AALGTQPWQDFAEQETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRIL FT FAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDSLADMVSIGTLTAFS FT VVAVGVIVLRVREPDLPRGFKVPGYPVTPVLSVLACGYILASLHWYTWLAFSGWVAVAV FT IFYLMWGRHHSALNEEVP" FT CDS complement(169315..169860) FT /transl_table=11 FT /gene="rocD2" FT /locus_tag="Rv2321c" FT /product="PROBABLE ORNITHINE AMINOTRANSFERASE (C-terminus FT part) ROCD2 (ORNITHINE--OXO-ACID AMINOTRANSFERASE)" FT /function="INVOLVED IN ARGININE METABOLISM [CATALYTIC FT ACTIVITY: L-ORNITHINE + A 2-OXO ACID = L-GLUTAMATE FT 5-SEMIALDEHYDE + AN L-AMINO ACID]." FT /EC_number="2.6.1.13" FT /note="Rv2321c, (MTCY3G12.13), len: 181 aa. Probable rocD2, FT ornithine aminotransferase (EC: 2.6.1.13), highly similar FT to C-terminal region of other ornithine aminotransferases, FT e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa), FT FASTA scores: opt: 628, E(): 1.2e-32, (55.35% identity in FT 168 aa overlap); P3802|OAT_BACSU|ROCD from Bacillus FT subtilis (401 aa), FASTA scores: opt: 477, E(): 4.3e-23, FT (42.1% identity in 178 aa overlap); BAB42057|ROCD|SA0818 FT from Staphylococcus aureus subsp. aureus N315 (396 aa), FT FASTA scores: opt: 437, E(): 1.5e-20, (41.3% identity in FT 170 aa overlap); etc. Contains PS00600 Aminotransferases FT class-III pyridoxal-phosphate attachment site. BELONGS TO FT CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES. Rv2322c|MTCY3G12.12 (upstream ORF) and FT Rv2321c|MTCY3G12.13 appear to be an ornithine FT aminotransferase homologue but are frameshifted - we can FT find no sequence error in the cosmid to account for this." FT /db_xref="GOA:P71891" FT /db_xref="HSSP:2DKB" FT /db_xref="InterPro:IPR015422" FT /db_xref="UniProtKB/TrEMBL:P71891" FT /protein_id="CAB02069.1" FT /translation="MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAM FT VADREIFGVVHPGEHGSTFGGNPLAAAIGTPVVSMVVWGECQARSAKLGAHLHQRLADL FT IGDGAVALRGLGWWADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVITAQ FT EIDCAVRRFADALWEAGS" FT misc_feature complement(169747..169860) FT /note="PS00600 Aminotransferases class-III FT pyridoxal-phosphate attachment site" FT CDS complement(169860..170525) FT /transl_table=11 FT /gene="rocD1" FT /locus_tag="Rv2322c" FT /product="PROBABLE ORNITHINE AMINOTRANSFERASE (N-terminus FT part) ROCD1 (ORNITHINE--OXO-ACID AMINOTRANSFERASE)" FT /function="INVOLVED IN ARGININE METABOLISM [CATALYTIC FT ACTIVITY: L-ORNITHINE + A 2-OXO ACID = L-GLUTAMATE FT 5-SEMIALDEHYDE + AN L-AMINO ACID]." FT /EC_number="2.6.1.13" FT /note="Rv2322c, (MTCY3G12.12), len: 221 aa. Probable rocD1, FT ornithine aminotransferase (EC: 2.6.1.13), highly similar FT to N-terminal region of other ornithine aminotransferases, FT e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa), FT FASTA scores: opt: 770, E(): 8.7e-40, (55.7% identity in FT 201 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus FT aureus subsp. aureus N315 (396 aa) FASTA scores: opt: 632, FT E(): 2.2e-31, (46.1% identity in 208 aa overlap); FT P38021|OAT_BACSU|ROCD from Bacillus subtilis (401 aa), FT FASTA scores: opt: 626, E(): 5.1e-31, (43.1% identity in FT 218 aa overlap); etc. BELONGS TO CLASS-III OF FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. FT Rv2322c|MTCY3G12.12 and Rv2321c|MTCY3G12.13 (upstream ORF) FT appear to be an ornithine aminotransferase homologue but FT are frameshifted - we can find no sequence error in the FT cosmid to account for this." FT /db_xref="GOA:P71890" FT /db_xref="HSSP:2CAN" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/TrEMBL:P71890" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02068.1" FT /translation="MTNLADATQATMALVERHAAHNYSPLPVVAASAEGAWIADIDGLR FT YLDWLAAYSAVNLGHRNPASTATAHAQVDTVTLLNRALHADRLGPLGAALAQLCGKDVV FT LPMNSDAEAVESGLRVARKWGADVNGLPAGRHDIILANNNFHGHTSSVVSFSSDPAAGS FT GVEPSTPGLRSVPFGDAAAPAQTIDDNTVADLLEPIPGQAGIIVPADDYLPAASSTTC" FT CDS complement(170522..171430) FT /transl_table=11 FT /locus_tag="Rv2323c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2323c, (MTCY3G12.11), len: 302 aa. Conserved FT hypothetical protein, highly similar to others eg FT Q9FC91|2SCG58.22 CONSERVED HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor (288 aa), FASTA scores: opt: 561, FT E(): 7.3e-28, (46.95% identity in 279 aa overlap); FT P74535|SLL1336 HYPOTHETICAL 78.3 KDA PROTEIN from FT Synechocystis sp. (705 aa), FASTA scores: opt: 555, E(): FT 2.1e-27, (37.75% identity in 265 aa overlap); etc. Also FT similar to various hydrolases e.g. Q53797 BETA-HYDROXYLASE FT (BLEOMYCIN/PHLEOMYCIN BINDING PROTEIN, ANKYRIN HOMOLOGUE, FT BLEOMYCIN AND TRANSPORT PROTEIN) from Streptomyces FT verticillus (326 aa), FASTA scores: opt: 211, E(): 4.5e-06, FT (26.75% identity in 303 aa overlap); FT Q9X7M4|DDAH_STRCO|SC5F2A.01c NG,NG-dimethylarginine FT dimethylaminohydrolase (EC 3.5.3.18) (Dimethylargininase) FT (Dimethylarginine dimethylaminohydrolase) (258 aa), FASTA FT scores: opt: 209, E(): 4.9e-06, (27.15% identity in 243 aa FT overlap); G434715 beta-hydroxylase (bleomicin/phleomycin FT binding protein) from Streptomyces verticillus (326 aa), FT FASTA scores: opt: 211, E(): 4.5e-06, (26.75% identity in FT 303 aa overlap); etc." FT /db_xref="GOA:P71889" FT /db_xref="InterPro:IPR003198" FT /db_xref="UniProtKB/TrEMBL:P71889" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02067.1" FT /translation="MENTQRPSFDCEIRAKYRWFMTDSYVAAARLGSPARRTPRTRRYA FT MTPPAFFAVAYAINPWMDVTAPVDVQVAQAQWEHLHQTYLRLGHSVDLIEPISGLPDMV FT YTANGGFIAHDIAVVARFRFPERAGESRAYASWMSSVGYRPVTTRHVNEGQGDLLMVGE FT RVLAGYGFRTDQRAHAEIAAVLGLPVVSLELVDPRFYHLDTALAVLDDHTIAYYPPAFS FT TAAQEQLSALFPDAIVVGSADAFVFGLNAVSDGLNVVLPVAAMGFAAQLRAAGFEPVGV FT DLSELLKGGGSVKCCTLEIHP" FT CDS 171495..171941 FT /transl_table=11 FT /locus_tag="Rv2324" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY ASNC-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv2324, (MTCY3G12.10), len: 148 aa. Probable FT transcriptional regulatory protein, asnC-family, similar to FT other PUTATIVE ASNC-FAMILY REGULATORY PROTEINS e.g. FT Q9L101|SCL6.15C from Streptomyces coelicolor (150 aa) FASTA FT scores: opt: 466, E(): 2.4e-24, (52.8% identity in 142 aa FT overlap); Q9RKY4|SC6D7.14 PUTATIVE ASNC-FAMILY FT TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces FT coelicolor (165 aa), FASTA scores: opt: 266, E(): 5.5e-11, FT (32.4% identity in 145 aa overlap); Q9ZEP1|LRPA|SCE94.12c FT PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces FT coelicolor (150 aa), FASTA scores: opt: 249, E(): 6.9e-10, FT (33.35% identity in 147 aa overlap); etc. Also similar to FT P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis FT (150 aa), FASTA scores: opt: 261, E(): 1.1e-10, (36.4% FT identity in 143 aa overlap)." FT /db_xref="GOA:P71888" FT /db_xref="InterPro:IPR019888" FT /db_xref="UniProtKB/TrEMBL:P71888" FT /protein_id="CAB02066.1" FT /translation="MDRLDDTDERILAELAEHARATFAEIGHKVSLSAPAVKRRVDRML FT ESGVIKGFTTVVDRNALGWNTEAYVQIFCHGRIAPDQLRAAWVNIPEVVSAATVTGTSD FT AILHVLAHDMRHLEAALERIRSSADVERSESTVVLSNLIDRMPP" FT CDS complement(172170..173018) FT /transl_table=11 FT /locus_tag="Rv2325c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2325c, (MTCY3G12.09), len: 282 aa. Conserved FT hypothetical protein, equivalent to FT O32970|MLCB22.37c|ML0849 hypothetical protein from FT Mycobacterium leprae (283 aa), FASTA scores: opt: 1405, FT E(): 1.8e-78, (77.7% identity in 282 aa overlap). Also some FT similarity to other proteins e.g. Q9Z9J1|YBAF|BH0166 YBAF FT PROTEIN (BH0166 PROTEIN) (HYPOTHETICAL PROTEIN) from FT Bacillus halodurans (265 aa), FASTA scores: opt: 288, E(): FT 2.8e-10, (25.8% identity in 264 aa overlap); P70972|YBAF FT YBAF PROTEIN (HYPOTHETICAL PROTEIN) from Bacillus subtilis FT (265 aa), FASTA scores: opt: 259, E(): 1.5e-08, (25.45% FT identity in 224 aa overlap); AAK34821|SPY2193|Q99X13 FT Conserved hypothetical protein from Streptococcus pyogenes FT (266 aa), FASTA scores: opt: 232, E(): 6.5e-07, (25.1% FT identity in 267 aa overlap); etc." FT /db_xref="GOA:P64997" FT /db_xref="InterPro:IPR003339" FT /db_xref="UniProtKB/Swiss-Prot:P64997" FT /protein_id="CAB02065.1" FT /translation="MTTTSAPARNGTRRPSRPIVLLIPVPGSSVIHDLWAGTKLLVVFG FT ISVLLTFYPGWVTIGMMAALVLAAARIAHIPRGALPSVPRWLWIVLAIGFLTAALAGGT FT PVVAVGGVQLGLGGALHFLRITALSVVLLALGAMVSWTTNVAEISPAVATLGRPFRVLR FT IPVDEWAVALALALRAFPMLIDEFQVLYAARRLRPKRMPPSRKARRQRHARELIDLLAA FT AITVTLRRADEMGDAITARGGTGQLSAHPGRPKLADWVTLAITAMASGTAVAIESLILH FT S" FT CDS complement(173015..175108) FT /transl_table=11 FT /locus_tag="Rv2326c" FT /product="POSSIBLE TRANSMEMBRANE ATP-BINDING PROTEIN ABC FT TRANSORTER" FT /function="PROBABLY INVOLVED IN ACTIVE TRANSPORT ACCROSS FT THE MEMBRANE. THOUGHT TO BE RESPONSIBLE FOR ENERGY COUPLING FT TO THE TRANSPORT SYSTEM AND THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv2326c, (MTC3G12.08), len: 697 aa. Possible FT transmembrane ATP-binding protein ABC transporter (see FT citation below). Equivalent to Q9CCF9|ML0848 ABC FT TRANSPORTER from Mycobacterium leprae (724 aa), FASTA FT scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa FT overlap) and also to O32971|MLCB22.38c ABC-TYPE TRANSPORTER FT from Mycobacterium leprae (726 aa), FASTA scores: opt: FT 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap). FT Similar in part to other ABC TRANSPORTERS e.g. FT Q9WY65|TM0222 from Thermotoga maritima (266 aa), FASTA FT scores: opt: 407, E(): 4.2e-15, (38.0% identity in 213 aa FT overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site FT motif A (P-loop); and 2 x PS00211 ABC transporters family FT signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FT FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:P63399" FT /db_xref="HSSP:1L2T" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P63399" FT /protein_id="CAB02064.1" FT /translation="MCCAVCGPEPGRIGEVTPLGPCPAQHRGGPLRPSELAQASVMAAL FT CAVTAIISVVVPFAAGLALLGTVPTGLLAYRYRLRVLAAATVAAGMIAFLIAGLGGFMG FT VVHSAYIGGLTGIVKRRGRGTPTVVVSSLIGGFVFGAAMVGMLAAMVRLRHLIFKVMTA FT NVDGIAATLARMHMQGAAADVKRYFAEGLQYWPWVLLGYFNIGIMIVSLIGWWALSRLL FT ERMRGIPDVHKLDPPPGDDVDALIGPVPVRLDKVRFRYPRAGQDALREVSLDVRAGEHL FT AIIGANGSGKTTLMLILAGRAPTSGTVDRPGTVGLGKLGGTAVVLQHPESQVLGTRVAD FT DVVWGLPLGTTADVGRLLSEVGLEALAERDTGSLSGGELQRLALAAALAREPAMLIADE FT VTTMVDQQGRDALLAVLSGLTQRHRTALVHITHYDNEADSADRTLSLSDSPDNTDMVHT FT AAMPAPVIGVDQPQHAPALELVGVGHEYASGTPWAKTALRDINFVVEQGDGVLIHGGNG FT SGKSTLAWIMAGLTIPTTGACLLDGRPTHEQVGAVALSFQAARLQLMRSRVDLEVASAA FT GFSASEQDRVAAALTVVGLDPALGARRIDQLSGGQMRRVVLAGLLARAPRALILDEPLA FT GLDAASQRGLLRLLEDLRRARGLTVVVVSHDFAGMEELCPRTLHLRDGVLESAAASEAG FT GMS" FT misc_feature complement(173246..173290) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(173546..173569) FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature complement(173945..173989) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(174233..174256) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 175149..175640 FT /transl_table=11 FT /locus_tag="Rv2327" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2327, (MTCY3G12.07c), len: 163 aa. Conserved FT hypothetical protein, similar to FT Z80775|MTCY21D4.05c|Rv0042c from Mycobacterium tuberculosis FT (208 aa), FASTA scores: opt: 242, E(): 5e-08, (43.0% FT identity in 107 aa overlap). Also slight similarity to FT putative transcriptional regulatory proteins belonging to FT the MARR-FAMILY e.g. Q9CCY2/ML2696 from Mycobacterium FT leprae (243 aa), FASTA scores: opt: 245, E(): 3.7e-08, FT (35.35% identity in 150 aa overlap); Q9L135|SC6D11.20 from FT Streptomyces coelicolor (155 aa), FASTA scores: opt: 242, FT E(): 3.9e-08, (34.75% identity in 141 aa overlap); etc." FT /db_xref="GOA:P71885" FT /db_xref="InterPro:IPR000835" FT /db_xref="UniProtKB/TrEMBL:P71885" FT /protein_id="CAB02063.1" FT /translation="MSPSPAAANRSEVGGPLPGLGADLLAVVARLNRLATQRIQMPLPA FT AQARLLATIEAQGEARIGDLAAVDHCSQPTMTTQVRRLEDAGLVTRTADPGDARAVRIR FT ITPEGIRTLTAVRADRAAAIEPQLALLPPADRRVLADAVDVLRRLLDHAATTPGRATRQ FT " FT CDS 175892..177040 FT /transl_table=11 FT /gene="PE23" FT /locus_tag="Rv2328" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2328, (MTCY3G12.06), len: 382 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS HOMOLOG from FT Mycobacterium marinum (638 aa), FASTA scores: opt: 495, FT E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc." FT /db_xref="GOA:P0A684" FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:P0A684" FT /protein_id="CAE55472.1" FT /translation="MQFLSVIPEQVESAAQDLAGIRSALSASYAAAAGPTTAVVSAAED FT EVSTAIASIFGAYGRQCQVLSAQASAFHDEFVNLLKTGATAYRNTEFANAQSNVLNAVN FT APARSLLGHPSAAESVQNSAPTLGGGHSTVTAGLAAQAGRAVATVEQQAAAAVAPLPSA FT GAGLAQVVNGVVTAGQGSAAKLATALQSAAPWLAKSGGEFIVAGQSALTGVALLQPAVV FT GVVQAGGTFLTAGTSAATGLGLLTLAGVEFSQGVGNLALASGTAATGLGLLGSAGVQLF FT SPAFLLAVPTALGGVGSLAIAVVQLVQGVQHLSLVVPNVVAGIAALQTAGAQFAQGVNH FT TMLAAQLGAPGIAVLQTAGGHFAQGIGHLTTAGNAAVTVLIS" FT CDS complement(177075..178622) FT /transl_table=11 FT /gene="narK1" FT /locus_tag="Rv2329c" FT /product="PROBABLE NITRITE EXTRUSION PROTEIN 1 NARK1 FT (NITRITE FACILITATOR 1)" FT /function="INVOLVED IN EXCRETION OF NITRITE PRODUCED BY THE FT DISSIMILATORY REDUCTION OF NITRATE." FT /note="Rv2329c, (MTCY3G12.05), len: 515 aa. Probable narK1, FT nitrite extrusion protein, possibly member of major FT facilitator superfamily (MFS). Equivalent to FT O32974|MLCB22.41c|NARK|ML0844 PUTATIVE NITRITE EXTRUSION FT PROTEIN from Mycobacterium leprae (517 aa), FASTA scores: FT opt: 2224, E(): 1.9e-129, (69.3% identity in 488 aa FT overlap). Also highly similar to others e.g. P94933 NITRITE FT EXTRUSION PROTEIN from Mycobacterium fortuitum (471 aa), FT FASTA scores: opt: 1969, E(): 8.6e-114, (62.1% identity in FT 459 aa overlap); P37758|NARU_ECOLI NITRITE EXTRUSION FT PROTEIN 2 from Escherichia coli strain K12 (462 aa), FASTA FT scores: opt: 792, E(): 2.3e-41, (36.95% identity in 476 aa FT overlap); P10903|NARK_ECOLI nitrite extrusion protein FT (nitrite facilitator 1) from Escherichia coli strain K12 FT (463 aa), FASTA scores: opt: 784, E(): 7e-41, (35.3% FT identity in 468 aa overlap); etc. Also similar to FT RV0261c|Z86089|MTCY6A4_5 from Mycobacterium tuberculosis FT (469 aa), FASTA scores: opt: 2000, E(): 1.1e-115, (62.6% FT identity in 470 aa overlap). BELONGS TO THE NARK/NASA FT FAMILY OF TRANSPORTERS." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:P71883" FT /protein_id="CAB02061.1" FT /translation="MEQHTLLQREESPRSPAAPSLRRLGGSRHITHWDPEDLGAWEAGN FT KGIARRNLLWSVVTVHLGYSVWTLWPVLELLMPQDVYGFSTSDKFLLGTIATLFGAFLR FT MPYALASAIFGGRNWATFSAIVLLIPAIGTTVLLTHPGLPLWPYLVCAALTGLGGGNFA FT SSMSNANAFYPHRLKGSALGIAGGVGNLGVPAIQLVGLLAIATVGERKPYLVCALYVVL FT VAIAVIGVSLFMNNVEQHRVQVNRLRPIVSAVLSTRDTWLLSLLYLGTFGSFIGFSFVF FT GQVLQTNFLACGQSPARATLHAVELAFVGPLLAAVARIYGGRLADRVGGSRLTLIVFVA FT MTLAAGLLISASTLEGRHVGQHRGATMVGYFVCFVALFVLSGLGNGSVYKMIPTIFEAC FT SRSLDLSEAERRDWSRIISGVVIGFVAAFGALGGVGINMALRESYLSTGSGTDAFWIFM FT MCYAAAAVLTWKVYDRRTVTDMGMLQAALVRQPASTPAELIGPRTQSDRFSGCSISA" FT CDS complement(178856..179383) FT /transl_table=11 FT /gene="lppP" FT /locus_tag="Rv2330c" FT /product="PROBABLE LIPOPROTEIN LPPP" FT /function="UNKNOWN" FT /note="Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP, FT lipoprotein. Contains signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:P65302" FT /db_xref="UniProtKB/Swiss-Prot:P65302" FT /protein_id="CAB02060.1" FT /translation="MRRQRSAVPILALLALLALLALIVGLGASGCAWKPPTTRPSPPNT FT CKDSDGPTADTVRQAIAAVPIVVPGSKWVEITRGHTRNCRLHWVQIIPTIASQSTPQQL FT LFFDRNIPLGSPTRNPKPYITVLPAGDDTVTVQYQWQIGSDQECCPTGIGTVRFHIGSD FT GKLEALGSIPHQ" FT CDS 179458..179844 FT /transl_table=11 FT /locus_tag="Rv2331" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. FT Hypothetical unknown protein; shortened version of FT MTCY3G12.03c to eliminate overlap with MTCY3G12.04." FT /db_xref="UniProtKB/Swiss-Prot:P0A5G3" FT /protein_id="CAB02075.1" FT /translation="MPPVFLPQIGRLTPDAVGEAIGIAADDIPMAARWIGSRPCSLIGQ FT PNTMGDEMGYLGPGLAGQRCVDRLVMGASRSTCSRLPVIASVDERLSVLKPVRPRLHSI FT SFIFKGRPGEVYLTVTGYNFRGVP" FT CDS 179901..180239 FT /transl_table=11 FT /locus_tag="Rv2331A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2331A, len: 112 aa. Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q79FF7" FT /protein_id="CAE55473.1" FT /translation="MKGHLATFGHPALPTYRGSWLSREPGSPYRLPAGAGRDRGDACRR FT IPRRTGSGTLLRPGQRCTFAANADPMAKGVDRALCEIVAERRQLDLDLAKAQVRSALAN FT QRYHRDVH" FT CDS 180269..181915 FT /transl_table=11 FT /gene="mez" FT /locus_tag="Rv2332" FT /product="PROBABLE [NAD] DEPENDENT MALATE OXIDOREDUCTASE FT MEZ (MALIC ENZYME) (NAD-MALIC ENZYME) (MALATE DEHYDROGENASE FT (OXALOACETATE DECARBOXYLATING)) (PYRUVIC-MALIC CARBOXYLASE) FT (NAD-ME)" FT /function="CATALIZES THE OXIDATIVE DECARBOXYLATION OF FT MALATE INTO PYRUVATE, IMPORTANT FOR A WIDE RANGE OF FT METABOLIC PATHWAYS [CATALYTIC ACTIVITY: (S)-MALATE + NAD(+) FT = PYRUVATE + CO(2) + NADH]." FT /EC_number="1.1.1.38" FT /note="Rv2332, (MTCY3G12.02c, MTCY98.01, MT2394), len: 548 FT aa. Probable mez, malate oxidoreductase [NAD] dependent (EC FT 1.1.1.38) (malic enzyme), highly similar to others e.g. FT O34389|MALS PUTATIVE MALOLACTIC ENZYME [INCLUDES: MALIC FT ENZYME (EC 1.1.1.-); L-LACTATE DEHYDROGENASE (EC 1.1.1.27)] FT from Bacillus subtilis (566 aa), FASTA scores: opt: 1927, FT E(): 5.5e-111, (52.9% identity in 539 aa overlap); FT P45868|MAO2_BACSU|YWKA PROBABLE NAD-DEPENDENT MALIC ENZYME FT from Bacillus subtilis (582 aa), FASTA scores: opt: 1849, FT E(): 3.6e-106, (50.45% identity in 543 aa overlap); FT Q48796|MLES_OENOE MALOLACTIC ENZYME from Oenococcus oeni FT (541 aa), FASTA scores: opt: 1540, E(): 3.6e-87, (44.2% FT identity in 536 aa overlap); etc. BELONGS TO THE MALIC FT ENZYMES FAMILY. N-terminus shortened since first submission FT (previously 652 aa)." FT /db_xref="GOA:P71880" FT /db_xref="HSSP:1LLQ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P71880" FT /protein_id="CAB02059.2" FT /translation="MSDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLTL FT DQQAERVWHQLQSLATELGRNLLLEQLHYRHEVLYFKVLADHLPELMPVVYTPTVGEAI FT QRFSDEYRGQRGLFLSIDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGVGGI FT QIAVGKLALYTAGGGVDPRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYDEFVS FT RYIETAQRLFPRAILHFEDFGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAVYSGLK FT VTGIPLRDQTIVVFGAGTAGMGIADQIRDAMVADGATLEQAVSQIWPIDRPGLLFDDMD FT DLRDFQVPYAKNRHQLGVAVGDRVGLSDAIKIASPTILLGCSTVYGAFTKEVVEAMTAS FT CKHPMIFPLSNPTSRMEAIPADVLAWSNGRALLATGSPVAPVEFDETTYVIGQANNVLA FT FPGIGLGVIVAGARLITRRMLHAAAKAIAHQANPTNPGDSLLPDVQNLRAISTTVAEAV FT YRAAVQDGVASRTHDDVRQAIVDTMWLPAYD" FT CDS complement(181869..183482) FT /transl_table=11 FT /locus_tag="Rv2333c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT FT PROTEIN" FT /function="THOUGHT TO BE INVOLVED IN A TRANSPORT SYSTEM FT ACROSS THE MEMBRANE (PERHAPS DRUG TRANSPORT): RESPONSIBLE FT FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE FT MEMBRANE." FT /note="Rv2333c, (MTCY3G12.01), len: 537 aa. Probable FT conserved integral membrane transport protein, member of FT major facilitator superfamily (MFS) possibly involved in FT transport of drug, highly similar to many e.g. FT Q9RL22|C5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from FT Streptomyces coelicolor (489 aa), FASTA scores: opt: 1031, FT E(): 4e-55, (37.4% identity in 412 aa overlap); FT Q9L0L9|SCD82.12 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from FT Streptomyces coelicolor (490 aa), FASTA scores: opt: 883, FT E(): 3.8e-46, (36.35% identity in 407 aa overlap); FT Q9ZBW5|SC4B5.03c PUTATIVE INTEGRAL MEMBRANE EFFLUX PROTEIN FT from Streptomyces coelicolor (504 aa), FASTA scores: opt: FT 899, E(): 4.1e-47, (37.4% identity in 415 aa overlap); FT P39886|TCMA_STRGA tetracenomycin C resistance and export FT protein from Streptomyces glaucescens (538 aa), FASTA FT scores: opt: 839, E(): 1.9e-43, (32.3% identity in 489 aa FT overlap); etc. Also highly similar to FT Rv2459|O53186|MTV008.15 PROBABLE CONSERVED INTEGRAL FT MEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis FT strain H37Rv (508 aa), FASTA scores: opt: 1385, E(): FT 1.5e-76, (44.05% identity in 504 aa overlap); and FT AAK46834|MT2534 DRUG TRANSPORTER from Mycobacterium FT tuberculosis strain CDC1551 (523 aa), FASTA scores: opt: FT 1385, E(): 1.5e-76, (44.4% identity in 504 aa overlap)." FT /db_xref="GOA:P71879" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:P71879" FT /protein_id="CAB02058.1" FT /translation="MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQ FT WVVASYSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTTARGA FT QGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPTLGGLLVDQWGWRS FT IFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQLLFIVAVGALVYAVIEGPQIGWT FT SVQTIVMLWTAAVGCALFVWLERRSSNPMMDLTLFRDTSYALAIATICTVFFAVYGMLL FT LTTQFLQNVRGYTPSVTGLMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGL FT LMLIFSEHRSSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRAIG FT STIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRH FT IEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAM FT TVECAVSHMPGATWCRLWPA" FT CDS 183957..184889 FT /transl_table=11 FT /gene="cysK1" FT /locus_tag="Rv2334" FT /standard_name="cysK" FT /product="PROBABLE CYSTEINE SYNTHASE A CYSK1 FT (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE FT (THIOL)-LYASE A) (CSASE A)" FT /function="INVOLVED IN CYSTEINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY: O3-ACETYL-L-SERINE + H(2)S = L-CYSTEINE + FT ACETATE]." FT /EC_number="2.5.1.47" FT /note="Rv2334, (MT2397, MTCY98.03), len: 310 aa. Probable FT cysK1, cysteine synthase A (EC 4.2.99.8), equivalent to FT O32978|CYSK_MYCLE|ML0839|MLCB22.47 CYSTEINE SYNTHASE A from FT Mycobacterium leprae (310 aa), FASTA scores: opt: 1756, FT E(): 8.6e-96, (85.8% identity in 310 aa overlap). Also FT highly similar to other CYSTEINE SYNTHASES e.g. FT Q9JQL6|CYSK|NMA0974|NMB0763 PUTATIVE CYSTEINE SYNTHASE from FT Neisseria meningitidis (serogroup A and B) (310 aa), FASTA FT scores: opt: 1368, E(): 4.6e-73, (66.45% identity in 310 aa FT overlap); P73410|CYSK_SYNY3|SLR1842 from Synechocystis sp FT (312 aa), FASTA scores: opt: 1310, E(): 1.2e-69, (64.65% FT identity in 311 aa overlap); FT Q43725|CYSM_ARATH|OASC|ACS1|AT3G59760|F24G16.30 CYSTEINE FT SYNTHASE (MITOCHONDRIAL PRECURSOR) from Arabidopsis FT thaliana (Mouse-ear cress) (424 aa), FASTA scores: opt: FT 1253, E(): 3.2e-66, (59.2% identity in 309 aa overlap) (has FT its N-terminus longer 104 aa); etc. Contains PS00901 FT Cysteine synthase/cystathionine beta-synthase P-phosphate FT attachment site. BELONGS TO THE CYSTEINE FT SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. Note that FT previously known as cysK." FT /db_xref="GOA:P0A534" FT /db_xref="InterPro:IPR001926" FT /db_xref="PDB:2Q3B" FT /db_xref="UniProtKB/Swiss-Prot:P0A534" FT /protein_id="CAE55474.1" FT /translation="MSIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKD FT RIGVAMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMSLERRM FT LLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYFVPQQFENPANPAIHRVTTAEEVW FT RDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAASPVLSGGQKGPHPIQG FT IGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARRP FT ENAGKLIVVVLPDFGERYLSTPLFADVAD" FT misc_feature 184053..184109 FT /note="PS00901 Cysteine synthase/cystathionine FT beta-synthase P-phosphate attachment site" FT CDS 184893..185582 FT /transl_table=11 FT /gene="cysE" FT /locus_tag="Rv2335" FT /product="PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT)" FT /function="INVOLVED IN CYSTEINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY: ACETYL-CoA + L-SERINE = CoA + FT O-ACETYL-L-SERINE]." FT /EC_number="2.3.1.30" FT /note="Rv2335, (MTCY98.04), len: 229 aa. Probable cysE, FT serine acetyltransferase (EC 2.3.1.30), equivalent to FT O32979|CYSE|ML0838 SERINE ACETYLTRANSFERASE from FT Mycobacterium leprae (227 aa), FASTA scores: opt: 1152, FT E(): 9.6e-62, (76.4% identity in 229 aa overlap). Also FT highly similar, except in C-terminal part, to others e.g. FT Q9HXI6|CYSE|PA3816 O-ACETYLSERINE SYNTHASE from Pseudomonas FT aeruginosa (258 aa), FASTA scores: opt: 737, E(): 6e-37, FT (61.3% identity in 168 aa overlap); P23145|NIFP_AZOCH FT PROBABLE SERINE ACETYLTRANSFERASE from Azotobacter FT chroococcum mcd 1 (269 aa), FASTA scores: opt: 718, E(): FT 8.4e-36, (55.45% identity in 220 aa overlap); FT Q06750|CYSE_BACSU SERINE ACETYLTRANSFERASE from Bacillus FT subtilis (217 aa), FASTA scores: opt: 640, E(): 3.1e-31, FT (48.0% identity in 200 aa overlap); etc. Contains PS00101 FT Bacterial hexapeptide-repeat containing-transferases FT signature. BELONGS TO THE CYSE/LACA/LPXA/NODL FAMILY OF FT ACETYLTRANSFERASES. COMPOSED OF MULTIPLE REPEATS OF FT [LIV]-G-X(4)." FT /db_xref="GOA:P95231" FT /db_xref="InterPro:IPR018357" FT /db_xref="UniProtKB/TrEMBL:P95231" FT /protein_id="CAB06152.1" FT /translation="MLTAMRGDIRAARERDPAAPTALEVIFCYPGVHAVWGHRLAHWLW FT QRGARLLARAAAEFTRILTGVDIHPGAVIGARVFIDHATGVVIGETAEVGDDVTIYHGV FT TLGGSGMVGGKRHPTVGDRVIIGAGAKVLGPIKIGEDSRIGANAVVVKPVPPSAVVVGV FT PGQVIGQSQPSPGGPFDWRLPDLVGASLDSLLTRVARLEALGGGPQAAGVIRPPEAGIW FT HGEDFSI" FT misc_feature 185268..185354 FT /note="PS00101 Bacterial hexapeptide-repeat FT containing-transferases signature" FT CDS 185998..186966 FT /transl_table=11 FT /locus_tag="Rv2336" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN. MAY BE INVOLVED IN VIRULENCE." FT /note="Rv2336, (MTCY98.05), len: 322 aa. Hypothetical FT unknown protein (see Rindi et al., 2001)." FT /db_xref="UniProtKB/TrEMBL:P95232" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06153.1" FT /translation="MDVPHEQPALSSSKSNRFTSQRQTTGVGTTTVERLEPRLSPASRH FT ITEAKAFGTECHVSSFTREQDPDRAVRVEQIHGEAYVAAGHVYESALDELGRLDNSNAE FT FILDKARGSTRETEVIYLHAVPAEPLSGSQGEGGLRIVGISAVGSIDDLSAFKAAKPSM FT GLAHQRKLYDAIEDLGHGGVKEIAALSVTADAPPTVSYSLIREVLRLYHRTGEKLIITF FT AMPAYAKMVMNFGRFAMPQVGEPFYAHRNNDPRTSNDLLLVPSIVEPSNFLENISRGVV FT TADDGPTARRRFATLCYMTDGLDDYFMPLTRQVLSEGIQDI" FT CDS complement(187030..188148) FT /transl_table=11 FT /locus_tag="Rv2337c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2337c, (MTCY98.06c), len: 372 aa. Hypothetical FT unknown protein, sharing some similarity with FT Q9RI33|SCJ12.27c HYPOTHETICAL 37.2 KDA PROTEIN from FT Streptomyces coelicolor (335 aa), BLAST scores: 134 AND 46, FT (28% AND 33% identity, 52% AND 44% positive); FASTA scores: FT opt: 176, E(): 0.00042, (31.95% identity in 355 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:P95233" FT /protein_id="CAB06154.1" FT /translation="MRAGRWGPGMTGLDPAEFLSLVEAAALAPSADNRREVQLEHAGRR FT VRLWGDQTWRSAPEHRRIMSLVAIGAAVENVKLRAGRLGFETKVCWFPDSGNPGLVAEI FT DVDRLPQTRVDPIEGAIERRRTNRRVRFRGPPLSQGELGALSAEATGIDGIQLHWFDSP FT ETRKQILRLVRLAETERFRSRELHEELFSAVRFDIGWTASSDDGLPPGSLEVEAWMRPM FT FRGLRHWRVLRLLRTVGMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFER FT IWLRTTLLGAELQPFAASAVLSLPACEWVAPHVRAALVGGWNLLAPGHWPMMVFRIGHA FT RAPSVRTMRQSVEAYCYAPAERSGSDSESRFA" FT CDS complement(188268..189224) FT /transl_table=11 FT /gene="moeW" FT /locus_tag="Rv2338c" FT /product="POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEW" FT /function="INVOLVED IN MOLYBDOPTENUM COFACTOR BIOSYNTHESIS; FT THOUGHT TO BE INVOLVED IN THE BIOSYNTHESIS OF A FT DEMOLYBDO-COFACTOR (MOLYBDOPTERIN), NECESSARY FOR FT MOLYBDO-ENZYMES (BY SIMILARITY)." FT /note="Rv2338c, (MTCY98.07c), len: 318 aa. Possible moeW, FT molybdoptenum biosynthesis protein, showing some similarity FT to several molybdopterin biosynthesis proteins e.g. FT O27613|MTH1571 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEB FT HOMOLOG from Methanobacterium thermoautotrophicum (251 aa), FT FASTA scores: opt: 309, E(): 4.7e-14; (30.7% identity in FT 254 aa overlap); Q9KPQ5|VC2311 HESA/MOEB/THIF FAMILY FT PROTEIN from Vibrio cholerae (273 aa), FASTA scores: opt: FT 255, E(): 4e-09, (36.25% identity in 149 aa overlap); FT Q9PD34|XF1545 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from FT Xylella fastidiosa (276 aa), FASTA scores: opt: 233,E(): FT 1e-07, (33.6% identity in 128 aa overlap); etc. SEEMS TO FT BELONG TO THE HESA/MOEB/THIF FAMILY." FT /db_xref="GOA:P95234" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95234" FT /protein_id="CAB06155.1" FT /translation="MRAGADAPDSGRVKESAPWSYDEAFCRNLGLISPTEQQRLRNSRV FT AIAGMGGVGGIDMVALARMGIGKFTIADPDVFEIRNSNRQYGAMRSTNGQAKAEVMRNI FT VHDINPEAEIRAFCEPIGKENAATFLEGADVLVDGIDAFEIDLRRLLYREAQQRGIYAL FT GAGPLGFSTAWVVFDPKGMTFDRYFDLSDAMNTVDKFVAFIAGIAPSATHRRSIDLSYV FT DIENRTGPSVGLACHLASGVVAAEVLKILLGHGRVYAAPYFHQFDAYRSIYVRKRLRCG FT NRHPLQRVKRRLLARYINRRSAGVIPGLRYHRTEPSY" FT CDS 189854..192742 FT /transl_table=11 FT /gene="mmpL9" FT /locus_tag="Rv2339" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL9" FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /note="Rv2339, (MTCY98.08), len: 962 aa. Probable mmpL9, FT conserved transmembrane transport protein (see citation FT below), with strong similarity to other Mycobacterial FT proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE hypothetical FT 105.2 kDa protein from Mycobacterium leprae (959 aa), FASTA FT scores: opt: 3799, E(): 0, (59.3% identity in 937 aa FT overlap); G699237|U1740AB from Mycobacterium leprae; and FT MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from Mycobacterium FT tuberculosis. BELONGS TO THE MMPL FAMILY. TBparse score is FT 0.956." FT /db_xref="GOA:P95235" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/Swiss-Prot:P95235" FT /protein_id="CAB06156.1" FT /translation="MVPGEVHMSDTPSGPHPIIPRTIRLAAIPILLCWLGFTVFVSVAV FT PPLEAIGETRAVAVAPDDAQSMRAMRRAGKVFNEFDSNSIAMVVLESDQPLGEKAHRYY FT DHLVDTLVLDQSHIQHIQDFWRDPLTAAGAVSADGKAAYVQLYLAGNMGEALANESVEA FT VRKIVANSTPPEGIRTYVTGPAALFADQIAAGDRSMKLITGLTFAVITVLLLLVYRSIA FT TTLLILPMVFIGLGATRGTIAFLGYHGMVGLSTFVVNILTALAIAAGTDYAIFLVGRYQ FT EARHIGQNREASFYTMYRGTANVILGSGLTIAGATYCLSFARLTLFHTMGPPLAIGMLV FT SVAAALTLAPAIIAIAGRFGLLDPKRRLKTRGWRRVGTAVVRWPGPILATSVALALVGL FT LALPGYRPGYNDRYYLRAGTPVNRGYAAADRHFGPARMNPEMLLVESDQDMRNPAGMLV FT IDKIAKEVLHVSGVERVQAITRPQGVPLEHASIPFQISMMGATQTMSLPYMRERMADML FT TMSDEMLVAINSMEQMLDLVQQLNDVTHEMAATTREIKATTSELRDHLADIDDFVRPLR FT SYFYWEHHCFDIPLCSATRSLFDTLDGVDTLTDQLRALTDDMNKMEALTPQFLALLPPM FT ITTMKTMRTMMLTMRSTISGVQDQMADMQDHATAMGQAFDTAKSGDSFYLPPEAFDNAE FT FQQGMKLFLSPNGKAVRFVISHESDPASTEGIDRIEAIRAATKDAIKATPLQGAKIYIG FT GTAATYQDIRDGTKYDILIVGIAAVCLVFIVMLMITQSLIASLVIVGTVLLSLGTAFGL FT SVLIWQHFVGLQVHWTIVAMSVIVLLAVGSDYNLLLVSRFKEEVGAGLKTGIIRAMAGT FT GAVVTSAGLVFAFTMASMAVSELRVIGQVGTTIGLGLLFDTLVVRSFMTPSIAALLGRW FT FWWPNMIHSRPTVPEAHTRQGARRIQPHLHRG" FT CDS complement(192828..194069) FT /transl_table=11 FT /gene="PE_PGRS39" FT /locus_tag="Rv2340c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2340c, (MTCY98.09c), len: 413 aa. Member of the FT Mycobacterium tuberculosis PE_family, PGRS subfamily of FT gly-rich proteins (see citations below), similar to others FT eg YI18_MYCTU|Q50615|Rv1818c|MTCY1A11.25 PE-PGRS FAMILY FT PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA FT scores: opt: 710, E(): 1.4e-22, (41.0% identity in 368 aa FT overlap); O53884|Rv0872v|MTV043.65c PGRS-FAMILY PROTEIN FT from Mycobacterium tuberculosis (606 aa), FASTA scores: FT opt: 708, E(): 1.9e-22, (42.4% identity in 389 aa overlap); FT etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7D7A7" FT /protein_id="CAE55475.1" FT /translation="MSHVTAAPNVLAASAGELAAIGSTMRAANAAAAAPTAGVLAAGGD FT DVSAGIAALFGARAQAYQAISAQAALFHDRFVQILQEGAAAYAMAEAANALPLQKAQGV FT VSELAQDRTGGTGTGQSRGAGGFGGVGQAGGKGWDGGPIGNGQVGEQHGAGQLGSTDGN FT PGVAGAAHGSGVSASHGSGATGAAGVADPGGSGAGVGSAAGNGTGAGSADAVGGAGTGR FT DIVGSVRGDGGVGMASGDGGLSTGAAGASAEGGLMPGFGGAPWVGGHWGLGGEGHSGAI FT GGVGEQVAPAVATAPAVSPATTSAVAAESGSTPATKAQAMHATTNPGNAAHQGNPADPG FT NSARRADGGRDEQLLLLPLTSLRGLRHTLKKLSGLRARNGLLTASGDNASGSGRPWDRD FT QLLRALGLRPPGHE" FT tRNA complement(194568..194640) FT /gene="tRNA-Asn(GTT)" FT /product="transfer RNA-Asn(GTT)" FT /anticodon=(pos:194605..194607,aa:Asn) FT CDS 194758..195177 FT /transl_table=11 FT /gene="lppQ" FT /locus_tag="Rv2341" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPPQ" FT /function="UNKNOWN" FT /note="Rv2341, (MTCY98.10), len: 139 aa. Probable lppQ, FT conserved lipoprotein, showing some similarity with FT Rv1228|O33224|LPQX|MTCI61.11 from Mycobacterium FT tuberculosis (185 aa), FASTA scores: opt: 155; E(): 0.0073; FT (31.9% identity in 116 aa overlap). Also shows few FT similarity with P29228|VLPA_MYCHR variant surface antigen A FT precursor from Mycoplasma hyorhinis (157 aa), FASTA scores: FT opt: 96, E(): 7.3, (23.1% identity in 143 aa overlap). FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site. TBparse score is 0.929." FT /db_xref="UniProtKB/TrEMBL:P95237" FT /protein_id="CAB06158.1" FT /translation="MPVGGRQHVFEKLASILGLVAAPLMLLGLSACGRSAGKTSEPTCP FT TEPIDAADSSTTPDPSCVVRATEINGNGSRIQTWTGSYDAAATQSGGVCGGTCNFHATV FT RFTVDEGQISGSVDQVYQAAMVAIATRPTSPSLAP" FT misc_feature 194821..194853 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 195433..195690 FT /transl_table=11 FT /locus_tag="Rv2342" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2342, (MTCY98.11), len: 85 aa. Conserved FT hypothetical protein, highly similar to Q9CCG1|ML0834 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FT FASTA scores: opt: 392, E(): 2.9e-20, (78.2% identity in 78 FT aa overlap). N-terminus highly similar to N-terminal part FT of Q9L085|SCC24.32 PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (108 aa), FASTA scores: opt: 122, FT E(): 0.077, (39.15% identity in 46 aa overlap). TBparse FT score is 0.887." FT /db_xref="UniProtKB/TrEMBL:P95238" FT /protein_id="CAB06162.1" FT /translation="MIGYVAVLGLGYVLGAKAGRRRYEQIASTYRALTGSPVARSMIEG FT GRRKIANRISPDAGFVTLAEIDNQTAVVQRGVERQPKTAR" FT CDS complement(195694..197613) FT /transl_table=11 FT /gene="dnaG" FT /locus_tag="Rv2343c" FT /product="PROBABLE DNA PRIMASE DNAG" FT /function="DNA PRIMASE IS THE POLYMERASE THAT SYNTHESIZES FT SMALL RNA PRIMERS FOR THE OKAZAKI FRAGMENTS ON BOTH FT TEMPLATE STRANDS REPLICATION FORKS DURING CHROMOSOMAL DNA FT SYNTHESIS." FT /EC_number="2.7.7.-" FT /note="Rv2343c, (MTCY98.12c), len: 639 aa. Probable dnaG, FT DNA primase (EC 2.7.7.-), equivalent to FT O52200|PRIM_MYCSM|DNAG DNA PRIMASE from Mycobacterium FT smegmatis (636 aa), FASTA scores: opt: 3504, E(): 5.5e-202, FT (81.55% identity in 639 aa overlap); and Q9CCG2|DNAG|ML0833 FT DNA PRIMASE from Mycobacterium leprae (642 aa), FASTA FT scores: opt: 3443, E(): 2.5e-198, (80.4% identity in 642 aa FT overlap). Also highly similar to many DNA primases e.g. FT Q9S1N4|PRIM_STRCO|DNAG|SC7A8.07c from Streptomyces FT coelicolor (641 aa), FASTA scores: opt: 1899, E(): FT 5.1e-106, (47.9% identity in 643 aa overlap); FT P74893|PRIM_SYNP7|DNAG from Synechococcus sp. strain PCC FT 7942 (Anacystis nidulans R2) (616 aa), FASTA scores: opt: FT 860, E(): 6.6e-44, (35.3% identity in 513 aa overlap); FT P05096|PRIM_BACSU from Bacillus subtilis (603 aa) FASTA FT scores: opt: 800, E(): 2.5e-40, (33.7% identity in 430 aa FT overlap); etc. TBparse score is 0.894." FT /db_xref="GOA:P63962" FT /db_xref="HSSP:1D0Q" FT /db_xref="InterPro:IPR002694" FT /db_xref="UniProtKB/Swiss-Prot:P63962" FT /protein_id="CAB06159.1" FT /translation="MSGRISDRDIAAIREGARIEDVVGDYVQLRRAGADSLKGLCPFHN FT EKSPSFHVRPNHGHFHCFGCGEGGDVYAFIQKIEHVSFVEAVELLADRIGHTISYTGAA FT TSVQRDRGSRSRLLAANAAAAAFYAQALQSDEAAPARQYLTERSFDAAAARKFGCGFAP FT SGWDSLTKHLQRKGFEFEELEAAGLSRQGRHGPMDRFHRRLLWPIRTSAGEVVGFGARR FT LFDDDAMEAKYVNTPETLLYKKSSVMFGIDLAKRDIAKGHQAVVVEGYTDVMAMHLAGV FT TTAVASCGTAFGGEHLAMLRRLMMDDSFFRGELIYVFDGDEAGRAAALKAFDGEQKLAG FT QSFVAVAPDGMDPCDLRLKCGDAALRDLVARRTPLFEFAIRAAIAEMDLDSAEGRVAAL FT RRCVPMVGQIKDPTLRDEYARQLAGWVGWADVAQVIGRVRGEAKRTKHPRLGRLGSTTI FT ARAAQRPTAGPPTELAVRPDPRDPTLWPQREALKSALQYPALAGPVFDALTVEGFTHPE FT YAAVRAAIDTAGGTSAGLSGAQWLDMVRQQTTSTVTSALISELGVEAIQVDDDKLPRYI FT AGVLARLQEVWLGRQIAEVKSKLQRMSPIEQGDEYHALFGDLVAMEAYRRSLLEQASGD FT DLTA" FT CDS complement(197618..198913) FT /transl_table=11 FT /gene="dgt" FT /locus_tag="Rv2344c" FT /product="PROBABLE DEOXYGUANOSINE TRIPHOSPHATE FT TRIPHOSPHOHYDROLASE DGT (DGTPASE) (DGTP FT TRIPHOSPHOHYDROLASE)" FT /function="DGTPASE PREFERENTIALLY HYDROLYZES DGTP OVER THE FT OTHER CANONICAL NTPS [CATALYTIC ACTIVITY: DGTP + H(2)O = FT DEOXYGUANOSINE + TRIPHOSPHATE]." FT /EC_number="3.1.5.1" FT /note="Rv2344c, (MT2409, MTCY98.13c), len: 431 aa. Probable FT dgt, deoxyguanosine triphosphate triphosphohydrolase (EC FT 3.1.5.1), equivalent to Q9CCG3|DGT|ML0831 PUTATIVE FT DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE from FT Mycobacterium leprae (429 aa), FASTA scores: opt: 2316, FT E(): 1.6e-137, (83.85% identity in 421 aa overlap); and FT O52199|DGTP_MYCSM|AF027507_2 DEOXYGUANOSINETRIPHOSPHATE FT TRIPHOSPHOHYDROLASE from Mycobacterium smegmatis (428 aa), FT FASTA scores: opt: 1991, E(): 3.4e-117, (73.5% identity in FT 422 aa overlap). Also highly similar or similar to several FT deoxyguanosine triphosphate hydrolases e.g. FT Q9L2E9|SC7A8.09c PUTATIVE DEOXYGUANOSINETRIPHOSPHATE FT TRIPHOSPHOHYDROLASE from Streptomyces coelicolor (424 aa), FT FASTA scores: opt: 1216, E(): 1e-68, (51.05% identity in FT 425 aa overlap); BAB48544|MLL1093 DGTP TRIPHOSPHOHYDROLASE FT from Rhizobium loti (Mesorhizobium loti) (404 aa), FASTA FT scores: opt: 489, E(): 3.1e-23, (33.85% identity in 387 aa FT overlap); P15723|DGTP_ECOLI|DGT|B0160 from Escherichia coli FT strain K12 (504 aa), FASTA scores: opt: 173, E(): 0.0022, FT (31.65% identity in 259 aa overlap); etc. BELONGS TO THE FT DGTPASE FAMILY. TBparse score is 0.985." FT /db_xref="GOA:P0A540" FT /db_xref="InterPro:IPR006674" FT /db_xref="UniProtKB/Swiss-Prot:P0A540" FT /protein_id="CAB06163.1" FT /translation="MSASEHDPYDDFDRQRRVAEAPKTAGLPGTEGQYRSDFARDRARV FT LHSAALRRLADKTQVVGPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAH FT DIGHPPYGHNGERALDEVAASHGGFEGNAQNFRILTSLEPKVVDAQGLSAGLNLTRASL FT DAVTKYPWMRGDGLGSQRRKFGFYDDDRESAVWVRQGAPPERACLEAQVMDWADDVAYS FT VHDVEDGVVSERIDLRVLAAEEDAAALARLGEREFSRVSADELMAAARRLSRLPVVAAV FT GKYDATLSASVALKRLTSELVGRFASAAIATTRAAAGPGPLVRFRADLQVPDLVRAEVA FT VLKILALQFIMSDPRHLETQARQRERIHRVAHRLYSGAPQTLDPVYAAAFNTAADDAAR FT LRVVVDQIASYTEGRLERIDADQLGVSRNALD" FT CDS 198982..200964 FT /transl_table=11 FT /locus_tag="Rv2345" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2345, (MTCY98.14), len: 660 aa. Possible conserved FT transmembrane protein, with hydrophobic stretch at FT N-terminal end around position 180. Similar to O52198 FT HYPOTHETICAL 21.2 KDA PROTEIN (FRAGMENT) from Mycobacterium FT smegmatis (195 aa), FASTA scores: opt: 589, E(): 1.5e-23; FT (47.2% identity in 195 aa overlap). TBparse score is FT 0.895." FT /db_xref="GOA:P95241" FT /db_xref="InterPro:IPR007621" FT /db_xref="UniProtKB/TrEMBL:P95241" FT /protein_id="CAB06160.1" FT /translation="MRLVRLLGMVLTILAAGLLLGPPAGAQPPFRLSNYVTDNAGVLTS FT SGRTAVTAAVDRLYADRRIRLWVVYVENFSGQSALNWAQRTTRTSELGNYDALLAVATT FT GREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGDYSGAAVAAANGLNRSPSSSSRVV FT LLVTVGIIVIVVAVLLVVMRHRNRRRRADELAAARRVDPTNVMALAAVPLQALDDLSRS FT MVVDVDNAVRTSTNELALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDDNTPET FT PAQRRELLTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVELTTRIGP FT TQQRLAELHTEFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQAVSGRQAGLVDA FT VRAAESALGQARALLDAVDSAATDIRHAVASLPAVVADIQTGIKRANQHLQQAQQPQTG FT RTGDLIAARDAAARALDRARGAADPLTAFDQLTKVDADLDRLLATLAEEQATADRLNRS FT LEQALFTAESRVRAVSEYIDTRRGSIGPEARTRLAEAKRQLEAAHDRKSSNPTEAIAYA FT NAASTLAAHAQSLANADVQSAQRAYTRRGGNNAGAILGGIIIGDLLSGGTRGGLGGWIP FT TSFGGSSNAPGSSPDGGFLGGGGRF" FT CDS complement(201049..201333) FT /transl_table=11 FT /gene="esxO" FT /locus_tag="Rv2346c" FT /standard_name="ES6_6, Mtb9.9E" FT /product="PUTATIVE ESAT-6 LIKE PROTEIN ESXO (ESAT-6 LIKE FT PROTEIN 6)" FT /function="UNKNOWN" FT /note="Rv2346c, (MT2411, MTCY98.15c), len: 94 aa. esxO, FT ESAT-6 like protein (see citation below), member of FT Mycobacterium tuberculosis protein family with FT O53942|Rv1793|MTV049.15, O05300|Rv1198|MTCI364.10, FT MTCY15C10.33, P96364|MTCY07H7B.03|Rv1037c|MTCY10G2.12, FT MTCI364.10, etc. BELONGS TO THE ESAT6 FAMILY." FT /db_xref="InterPro:IPR009416" FT /db_xref="UniProtKB/Swiss-Prot:P95242" FT /protein_id="CAB06161.1" FT /translation="MTINYQFGDVDAHGAMIRAQAGLLEAEHQAIVRDVLAAGDFWGGA FT GSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA" FT CDS complement(201384..201680) FT /transl_table=11 FT /gene="esxP" FT /locus_tag="Rv2347c" FT /standard_name="ES6_7, QILSS" FT /product="PUTATIVE ESAT-6 LIKE PROTEIN ESXP (ESAT-6 LIKE FT PROTEIN 7)" FT /function="UNKNOWN" FT /note="Rv2347c, (MT2412, MTCY98.16c), len: 98 aa. esxP, FT ESAT-6 like protein (see citation below). Member of M. FT tuberculosis hypothetical QILSS protein family with Rv1197, FT Rv1792, Rv1038c and Rv3620c. BELONGS TO THE ESAT6 FAMILY. FT TBparse score is 0.896." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:P95243" FT /protein_id="CAB06145.1" FT /translation="MATRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGW FT SGMAEATSLDTMAQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS" FT CDS complement(201815..202141) FT /transl_table=11 FT /locus_tag="Rv2348c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2348c, (MTCY98.17c), len: 108 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P95244" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06164.1" FT /translation="MLLPLGPPLPPDAVVAKRAESGMLGGLSVPLSWGVAVPPDDYDHW FT APAPEDGADVDVQAAEGADAEAAAMDEWDEWQAWNEWVAENAEPRFEVPRSSSSVIPHS FT PAAG" FT CDS complement(202333..203859) FT /transl_table=11 FT /gene="plcC" FT /locus_tag="Rv2349c" FT /product="PROBABLE PHOSPHOLIPASE C 3 PLCC" FT /function="HYDROLYZES SPHINGOMYELIN IN ADDITION TO FT PHOSPHATIDYLCHOLINE. PROBABLE VIRULENCE FACTOR IMPLICATED FT IN THE PATHOGENESIS OF Mycobacterium tuberculosis AT THE FT LEVEL OF INTRACELLULAR SURVIVAL, BY THE ALTERATION OF CELL FT SIGNALING EVENTS OR BY DIRECT CYTOTOXICITY [CATALYTIC FT ACTIVITY: A PHOSPHATIDYLCHOLINE + H(2)O = 1,2- FT DIACYLGLYCEROL + CHOLINE PHOSPHATE]." FT /EC_number="3.1.4.3" FT /note="Rv2349c, (MT2414, MTCY98.18c), len: 508 aa. Probable FT plcC, phospolipase C 3 (EC 3.1.4.3) (see citations below), FT similar to other precursors of several phospolipases C e.g. FT P15713|PHLN_PSEAE|PA3319 NON-HEMOLYTIC PHOSPHOLIPASE C FT PRECURSOR from Pseudomonas aeruginosa (692 aa), FASTA FT scores: opt: 1013, E(): 9.3e-54, (38.85% identity in 525 aa FT overlap); P06200|PHLC_PSEAE HEMOLYTIC PHOSPHOLIPASE C FT PRECURSOR from Pseudomonas aeruginosa (730 aa), FASTA FT scores: opt: 630, E(): 1.5e-30, (35.15% identity in 535 aa FT overlap); Q9S816|T12J13.18|T21P5.4 PUTATIVE PHOSPHOLIPASE FT from Arabidopsis thaliana (Mouse-ear cress) (521 aa), FASTA FT scores: opt: 218, E(): 1e-05, (27.05% identity in 451 aa FT overlap); etc. Also highly similar to others from FT Mycobacterium tuberculosis e.g. FT Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C PHOSPHOLIPASE C 4 FT (514 aa), FASTA scores: opt: 2497, E(): 9e-144, (68.35% FT identity in 509 aa overlap); FT Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c PHOSPHOLIPASE C FT 1 (520 aa), FASTA scores: opt: 2494, E(): 1.4e-143, (68.1% FT identity in 514 aa overlap); FT P95246|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PHOSPHOLIPASE C FT 2 (512 aa), FASTA scores: opt: 2474, E(): 2.2e-142, (67.65% FT identity in 513 aa overlap); etc. BELONGS TO THE BACTERIAL FT PHOSPHOLIPASE C FAMILY. TBparse score is 0.938." FT /db_xref="GOA:P95245" FT /db_xref="InterPro:IPR007312" FT /db_xref="UniProtKB/Swiss-Prot:P95245" FT /protein_id="CAB06146.1" FT /translation="MSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEH FT IVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKGWNPETQALDPTGITLPYRINTTGG FT PNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIPIHY FT LLADTFTICDQYFSSLLGGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIM FT PQNLSDAGISWKVYNSKLLGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDF FT IRDVINNTLPQVSWVVPLTVESEHPSFPVAVGAVTIVNLIRVLLRNPAVWEKTALIIAY FT DEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSR FT GGLMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDH FT PVRQLPKVAKCVPNVVLGFLNEGLPYRVPYPQTTPVQESGPARPIPSGIC" FT CDS complement(203942..205480) FT /transl_table=11 FT /gene="plcB" FT /locus_tag="Rv2350c" FT /standard_name="mpcB" FT /product="PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 FT PLCB" FT /function="HYDROLYZES SPHINGOMYELIN IN ADDITION TO FT PHOSPHATIDYLCHOLINE. PROBABLE VIRULENCE FACTOR IMPLICATED FT IN THE PATHOGENESIS OF Mycobacterium tuberculosis AT THE FT LEVEL OF INTRACELLULAR SURVIVAL, BY THE ALTERATION OF CELL FT SIGNALING EVENTS OR BY DIRECT CYTOTOXICITY [CATALYTIC FT ACTIVITY: A PHOSPHATIDYLCHOLINE + H(2)O = 1,2- FT DIACYLGLYCEROL + CHOLINE PHOSPHATE]." FT /EC_number="3.1.4.3" FT /note="Rv2350c, (MT2415, MTCY98.19c), len: 512 aa. Probable FT plcB (alternate gene name: mpcB), membrane-associated FT phospolipase C 2 (EC 3.1.4.3) (see citations below), FT similar to other precursors of several phospolipases C e.g. FT P15713|PHLN_PSEAE|PA3319 NON-HEMOLYTIC PHOSPHOLIPASE C FT PRECURSOR from Pseudomonas aeruginosa (692 aa), FASTA FT scores: opt: 885, E(): 2.3e-44, (38.5% identity in 525 aa FT overlap); P06200|PHLC_PSEAE HEMOLYTIC PHOSPHOLIPASE C FT PRECURSOR from Pseudomonas aeruginosa (730 aa), FASTA FT scores: opt: 639, E(): 6.3e-30, (537 aa overlap); Q9RGS8 FT NON-HEMOLYTIC PHOSPHOLIPASE C from Pseudomonas aeruginosa FT (700 aa), FASTA scores: opt: 864, E(): 3.9e-43, (39.2% FT identity in 528 aa overlap); etc. Also highly similar to FT others from Mycobacterium tuberculosis e.g. FT Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c PHOSPHOLIPASE C FT 1 (520 aa), FASTA scores: opt: 2788, E(): 4.5e-156, (75.5% FT identity in 514 aa overlap); FT Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C PHOSPHOLIPASE C 4 FT (514 aa), FASTA scores: opt: 2623, E(): 2.1e-146, (71.5% FT identity in 512 aa overlap); FT P95245|PLCC|Rv2349c|MT2414|MTCY98.18c PHOSPHOLIPASE C 3 FT (508 aa), FASTA scores: opt: 2474, E(): 1.1e-137, (67.65% FT identity in 513 aa overlap); etc. BELONGS TO THE BACTERIAL FT PHOSPHOLIPASE C FAMILY. SUPPOSED MEMBRANE-ASSOCIATED, AT FT THE EXTRACELLULAR SIDE. TBparse score is 0.931." FT /db_xref="GOA:P95246" FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/Swiss-Prot:P95246" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06147.1" FT /translation="MTRRQFFAKAAAATTAGAFMSLAGPIIEKAYGAGPCPGHLTDIEH FT IVLLMQENRSFDHYFGTLSDTRGFDDTTPPVVFAQSGWNPMTQAVDPAGVTLPYRFDTT FT RGPLVAGECVNDPDHSWIGMHNSWNGGANDNWLPAQVPFSPLQGNVPVTMGFYTRRDLP FT IHYLLADTFTVCDGYFCSLLGGTTPNRLYWMSAWIDPDGTDGGPVLIEPNIQPLQHYSW FT RIMPENLEDAGVSWKVYQNKLLGALNNTVVGYNGLVNDFKQAADPRSNLARFGISPTYP FT LDFAADVRNNRLPKVSWVLPGFLLSEHPAFPVNVGAVAIVDALRILLSNPAVWEKTALI FT VNYDENGGFFDHVVPPTPPPGTPGEFVTVPDIDSVPGSGGIRGPIGLGFRVPCLVISPY FT SRGPLMVHDTFDHTSTLKLIRARFGVPVPNLTAWRDATVGDMTSTFNFAAPPNPSKPNL FT DHPRLNALPKLPQCVPNAVLGTVTKTAIPYRVPFPQSMPTQETAPTRGIPSGLC" FT CDS complement(205698..207236) FT /transl_table=11 FT /gene="plcA" FT /locus_tag="Rv2351c" FT /standard_name="mpcA" FT /product="PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 FT PLCA (MTP40 ANTIGEN)" FT /function="HYDROLYZES SPHINGOMYELIN IN ADDITION TO FT PHOSPHATIDYLCHOLINE. PROBABLE VIRULENCE FACTOR IMPLICATED FT IN THE PATHOGENESIS OF Mycobacterium tuberculosis AT THE FT LEVEL OF INTRACELLULAR SURVIVAL, BY THE ALTERATION OF CELL FT SIGNALING EVENTS OR BY DIRECT CYTOTOXICITY [CATALYTIC FT ACTIVITY: A PHOSPHATIDYLCHOLINE + H(2)O = 1,2- FT DIACYLGLYCEROL + CHOLINE PHOSPHATE]." FT /EC_number="3.1.4.3" FT /note="Rv2351c, (MTP40, MT2416, MTCY98.20c), len: 512 aa. FT Probable plcA (alternate gene name: mpcA), FT membrane-associated phospolipase C 1 (EC 3.1.4.3) (MTP40 FT antigen) (see citations below), similar to other precursors FT of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 FT NON-HEMOLYTIC PHOSPHOLIPASE C PRECURSOR from Pseudomonas FT aeruginosa (692 aa), FASTA scores: opt: 1064, E(): 4.3e-55, FT (39.85% identity in 517 aa overlap); P06200|PHLC_PSEAE FT HEMOLYTIC PHOSPHOLIPASE C PRECURSOR from Pseudomonas FT aeruginosa (730 aa), FASTA scores: opt: 562, E(): 1.6e-25, FT (35.35% identity in 481 aa overlap); Q9RGS8|PLCN|PHLN_BURPS FT NON-HEMOLYTIC PHOSPHOLIPASE C from Burkholderia FT pseudomallei (Pseudomonas pseudomallei) (700 aa), FASTA FT scores: opt: 843, E(): 4.4e-42, (40.5% identity in 531 aa FT overlap); etc. Also highly similar to others from FT Mycobacterium tuberculosis e.g. FT P95246|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PHOSPHOLIPASE C FT 2 (512 aa), FASTA scores: opt: 2788, E(): 1.2e-156, (75.5% FT identity in 514 aa overlap) (alias FT Q50561|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PHOSPHOLIPASE C FT 2 (521 aa), FASTA scores: opt: 2700, E(): 1.8e-151, (73.8% FT identity in 515 aa overlap)); FT Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C PHOSPHOLIPASE C 4 FT (514 aa), FASTA scores: opt: 2643, E(): 4.1e-148, (71.6% FT identity in 511 aa overlap); etc. BELONGS TO THE BACTERIAL FT PHOSPHOLIPASE C FAMILY. SUPPOSED MEMBRANE-ASSOCIATED, AT FT THE EXTRACELLULAR SIDE." FT /db_xref="GOA:Q04001" FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/Swiss-Prot:Q04001" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06148.1" FT /translation="MSRREFLTKLTGAGAAAFLMDWAAPVIEKAYGAGPCPGHLTDIEH FT IVLLMQENRSFDHYFGTLSSTNGFNAASPAFQQMGWNPMTQALDPAGVTIPFRLDTTRG FT PFLDGECVNDPEHQWVGMHLAWNGGANDNWLPAQATTRAGPYVPLTMGYYTRQDIPIHY FT LLADTFTICDGYHCSLLTGTLPNRLYWLSANIDPAGTDGGPQLVEPGFLPLQQFSWRIM FT PENLEDAGVSWKVYQNKGLGRFINTPISNNGLVQAFRQAADPRSNLARYGIAPTYPGDF FT AADVRANRLPKVSWLVPNILQSEHPALPVALGAVSMVTALRILLSNPAVWEKTALIVSY FT DENGGFFDHVTPPTAPPGTPGEFVTVPNIDAVPGSGGIRGPLGLGFRVPCIVISPYSRG FT PLMVSDTFDHTSQLKLIRARFGVPVPNMTAWRDGVVGDMTSAFNFATPPNSTRPNLSHP FT LLGALPKLPQCIPNVVLGTTDGALPSIPYRVPYPQVMPTQETTPVRGTPSGLCS" FT CDS complement(208084..209259) FT /transl_table=11 FT /gene="PPE38" FT /locus_tag="Rv2352c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2352c, (MTCY98.21c), len: 391 aa. Member of FT Mycobacterium tuberculosis PPE_family, highly similar to FT many e.g. Q10778|MTCY48.17|Y04H_MYCTU (734 aa), FASTA FT scores: opt: 713, E(): 2.8e-27, (37.7% identity in 430 aa FT overlap); Q10540|MTCY31.06c, Q11031|MTCY02B10.25c, FT Q10813|MTCY274.23c, P42611|MTV037.06C, P71868|MTCY03C7.23, FT P95248|MTCY98.22c, P71869|MTCY03C7.24c, etc." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q7D7A2" FT /protein_id="CAE55476.1" FT /translation="MILDFSWLPPEINSARIYAGAGSGPLFMAAAAWEGLAADLRASAS FT SFDAVIAGLAAGPWSGPASVAMAGAAAPYVGWLSAAAGQAELSAGQATAAATAFEAALA FT ATVHPAAVTANRVLLGALVATNILGQNTPAIAATEFDYVEMWAQDVGAMVGYHAGAAAV FT AETLTPFSVPPLDLAGLASQAGAQLTGMATSVSAALSPIAEGAVEGVPAVVAAAQSVAA FT GLPVDAALQVGQAAAYPASMLIGPMMQLAQMGTTANTAGLAGAEAAGLAAADVPTFAGD FT IASGTGLGGAGGLGAGMSAELGKARLVGAMSVPPTWEGSVPARMASSAMAGLGAMPAEV FT PAAGGPMGMMPMPMGMGGAGAGMPAGMMGRGGANPHVVQARPSVVPRVGIG" FT CDS complement(209689..210753) FT /transl_table=11 FT /gene="PPE39" FT /locus_tag="Rv2353c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2353c, (MTCY98.22c), len: 354 aa. Member of FT Mycobacterium tuberculosis PPE family, highly similar to FT many e.g. near ORF P95249|Rv2356c|MTCY98.25 from FT Mycobacterium tuberculosis (615 aa), FASTA scores: opt: FT 1566, E(): 3.2e-69, (66.1% identity in 349 aa overlap); FT Q10778|MTCY48.17, Q10540|MTCY31.06c, E241779|MTCY98, FT Q10813|MTCY274.23c, P71868|MTCY03C7.23, FT P71869|MTCY03C7.24c, P42611|MTV037.06C, E64997|MTCY98, FT Q10707|MTCY49.38C, P71657|MTCY02B10.25c, etc. TBparse score FT is 0.932. Note that he ATG and RBS appear to be provided by FT the IR of neighbouring IS6110." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q79FF3" FT /protein_id="CAE55477.1" FT /translation="MPGRFRNFGSQNLGSGNIGSTNVGSGNIGSTNVGSGNIGDTNFGN FT GNNGNFNFGSGNTGSNNIGFGNTGSGNFGFGNTGNNNIGIGLTGDGQIGIGGLNSGSGN FT IGFGNSGTGNVGLFNSGTGNVGFGNSGTANTGFGNAGNVNTGFWNGGSTNTGLANAGAG FT NTGFFDAGNYNFGSLNAGNINSSFGNSGDGNSGFLNAGDVNSGVGNAGDVNTGLGNSGN FT INTGGFNPGTLNTGFFSAMTQAGPNSGFFNAGTGNSGFGHNDPAGSGNSGIQNSGFGNS FT GYVNTSTTSMFGGNSGVLNTGYGNSGFYNAAVNNTGIFVTGVMSSGFFNFGTGNSGLLV FT SGNGLSGFFKNLFG" FT repeat_region 210738..210765 FT /note="28 bp Inverted repeat, TGAACCGCCCCGGCATGTCCGGAGACTC, FT at the left end of IS6110" FT repeat_region 210738..212092 FT /mobile_element="insertion sequence:IS6110-8" FT /note="IS6110-8, len: 1355 bp. Insertion sequence IS6110 FT element that appears to have inserted in 5'-end of FT MTCY98.031c but is not flanked by expected 3 bp direct FT repeats of target sequence." FT CDS 210789..211115 FT /transl_table=11 FT /locus_tag="Rv2354" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT SEQUENCE IS6110." FT /note="Rv2354, (MTCY98.23), len: 108 aa. Probable IS6110 FT transposase, highly similar to others. - 1 frameshift FT required to complete translation. TBparse score is 0.928." FT /db_xref="GOA:P0C5G9" FT /db_xref="InterPro:IPR002514" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9" FT /protein_id="CAB06166.1" FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD FT RPAR" FT CDS <211112..212050 FT /transl_table=11 FT /locus_tag="Rv2355" FT /product="PROBABLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT SEQUENCE IS6110." FT /note="Rv2355, (MTCY98.24), len: 312 aa. Probable IS6110 FT transposase, highly similar to others. TBparse score is FT 0.926." FT /db_xref="GOA:P0C5G8" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8" FT /protein_id="CAB06167.1" FT /translation="LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYDH FT INREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLG FT LSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVT FT DAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFS FT ERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWF FT NHRRLYQYCGDVPPVELEAAYYAQRQRPAAG" FT repeat_region complement(212065..212092) FT /note="28 bp Inverted repeat, TGAACCGCCCCGGTGAGTCCGGAGACTC, FT at the right end of IS6110" FT CDS complement(212849..214696) FT /transl_table=11 FT /gene="PPE40" FT /locus_tag="Rv2356c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2356c, (MTCY98.25), len: 615 aa. Member of FT Mycobacterium tuberculosis PPE_family, highly similar to FT others e.g. Q10778|MTCY48.17|YF48_MYCTU HYPOTHETICAL FT PPE-FAMILY PROTEIN (678 aa), FASTA scores: opt: 1888, E(): FT 1.9e-78, (54.4% identity in 667 aa overlap); FT Q10540|MTCY31.06c, E241779|MTCY98, P42611|MTV037.06c, FT Q10813|MTCY274.23c, P71657|MTCY02B10.25c, MTCY03C7.23, FT P71869|MTCY03C7.24c, etc. TBparse score is 0.929." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/Swiss-Prot:Q7D7A1" FT /protein_id="CAE55478.1" FT /translation="MVNFSVLPPEINSGRMFFGAGSGPMLAAAAAWDGLAAELGLAAES FT FGLVTSGLAGGSGQAWQGAAAAAMVVAAAPYAGWLAAAAARAGGAAVQAKAVAGAFEAA FT RAAMVDPVVVAANRSAFVQLVLSNVFGQNAPAIAAAEATYEQMWAADVAAMVGYHGGAS FT AAAAALAPWQQAVPGLSGLLGGAANAPAAAAQGAAQGLAELTLNLGVGNIGSLNLGSGN FT IGGTNVGSGNVGGTNLGSGNYGSLNWGSGNTGTGNAGSGNTGDYNPGSGNFGSGNFGSG FT NIGSLNVGSGNFGTLNLANGNNGDVNFGGGNTGDFNFGGGNNGTLNFGFGNTGSGNFGF FT GNTGNNNIGIGLTGDGQIGIGGLNSGTGNIGFGNSGNNNIGFFNSGDGNIGFFNSGDGN FT TGFGNAGNINTGFWNAGNLNTGFGSAGNGNVGIFDGGNSNSGSFNVGFQNTGFGNSGAG FT NTGFFNAGDSNTGFANAGNVNTGFFNGGDINTGGFNGGNVNTGFGSALTQAGANSGFGN FT LGTGNSGWGNSDPSGTGNSGFFNTGNGNSGFSNAGPAMLPGFNSGFANIGSFNAGIANS FT GNNLAGISNSGDDSSGAVNSGSQNSGAFNAGVGLSGFFR" FT CDS complement(214834..216225) FT /transl_table=11 FT /gene="glyS" FT /locus_tag="Rv2357c" FT /product="PROBABLE GLYCYL-tRNA SYNTHETASE GLYS FT (GLYCINE--tRNA LIGASE) (GLYRS)" FT /function="INVOLVED IN TRANSLATION MECHANISNS [CATALYTIC FT ACTIVITY: ATP + L-GLYCINE + TRNA(GLY) = AMP + PYROPHOSPHATE FT + L-GLYCYL-TRNA(GLY)]." FT /EC_number="6.1.1.14" FT /note="Rv2357c, (MTCY27.23, MTCY98.26), len: 463 aa. FT Probable glyS, glycyl-tRNA synthetase (EC 6.1.1.14), FT equivalent to Q9CCG4|GLYS|ML0826 PUTATIVE GLYCYL-TRNA FT SYNTHASE from Mycobacterium leprae (463 aa), FASTA scores: FT opt: 2898, E(): 1e-179, (90.2% identity in 459 aa overlap). FT Also highly similar to others e.g. FT Q9L2H9|SYG_STRCO|SCC121.07c from Streptomyces coelicolor FT (460 aa), FASTA scores: opt: 2210, E(): 2.9e-135, (68.3% FT identity in 457 aa overlap); Q9PPZ7|SYG_UREPA|GLYS|UU493 FT GLYCYL-TRNA SYNTHETASE from Ureaplasma parvum (Ureaplasma FT urealyticum biotype 1) (473 aa), FASTA scores: opt: 1254, FT E(): 1.7e-73, (45.25% identity in 462 aa overlap); FT P75425|SYG_MYCPN|GLYS|MPN354|MP482 GLYCYL-TRNA SYNTHETASE FT from Mycoplasma pneumoniae (449 aa), FASTA scores: opt: FT 1074, E(): 6.9e-62, (39.45% identity in 454 aa overlap); FT etc. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00179 Aminoacyl-transfer RNA synthetases FT class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA FT SYNTHETASE FAMILY." FT /db_xref="GOA:P67032" FT /db_xref="HSSP:1ATI" FT /db_xref="InterPro:IPR018160" FT /db_xref="UniProtKB/Swiss-Prot:P67032" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08466.1" FT /translation="MHHPVAPVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVEL FT KENIKRQWWRSVVTGRDDVVGIDSSIILPREVWVASGHVDVFHDPLVESLITHKRYRAD FT HLIEAYEAKHGHPPPNGLADIRDPETGEPGQWTQPREFNMMLKTYLGPIETEEGLHYLR FT PETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVE FT PATAKEWHQYWIDNRLQWYIDLGIRRENLRLWEHPKDKLSHYSDRTVDIEYKFGFMGNP FT WGELEGVANRTDFDLSTHARHSGVDLSFYDQINDVRYTPYVIEPAAGLTRSFMAFLIDA FT YTEDEAPNTKGGMDKRTVLRLDPRLAPVKAAVLPLSRHADLSPKARDLGAELRKCWNID FT FDDAGAIGRRYRRQDEVGTPFCVTVDFDSLQDNAVTVRERDAMTQDRVAMSSVADYLAV FT RLKGS" FT misc_feature complement(215578..215640) FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT misc_feature complement(215641..215664) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 216407..216814 FT /transl_table=11 FT /locus_tag="Rv2358" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY ARSR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv2358, (MTCY27.22c), len: 135 aa. Probable FT transcriptional regulator, arsR family, equivalent to FT Q9CCG5|ML0825 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL FT REGULATOR from Mycobacterium leprae (140 aa), FASTA scores: FT opt: 647, E(): 2e-34, (72.9% identity in 140 aa overlap). FT Also similar to others e.g. BAB48273|MLR0745 FT Transcriptional regulator from Rhizobium loti FT (Mesorhizobium loti) (104 aa), FASTA scores: opt: 185, E(): FT 3.4e-05, (43.25% identity in 74 aa overlap) (has its FT N-terminus shorter); P15905|ARR1_ECOLI arsenical resistance FT operon repressor from Escherichia coli (117 aa), FASTA FT scores: opt: 164, E(): 8.1e-05, (39.1% identity in 69 aa FT overlap); etc. Also similar to O53838|Rv0827|MTV043.19c FT PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium FT tuberculosis (130 aa), FASTA scores: opt: 201, E(): 4e-06, FT (35.7% identity in 98 aa overlap); and FT O69711|Rv3744|MTV025.092 PUTATIVE REGULATORY PROTEIN from FT Mycobacterium tuberculosis (120 aa), FASTA scores: opt: FT 209, E(): 1.2e-06, (35.5 % identity in 93 aa overlap). FT Contains possible helix-turn-helix motif at aa 72-93 (Score FT 1103, +2.94 SD). Belongs to the ARSR family of FT transciptional regulators." FT /db_xref="GOA:O05840" FT /db_xref="HSSP:1SMT" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:O05840" FT /protein_id="CAB08465.1" FT /translation="MVTSPSTPTAAHEDVGADEVGGHQHPADRFAECPTFPAPPPREIL FT DAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALHVPQPLVSQHLKILKAAGVVTGE FT RSGREVLYRLADHHLAHIVLDAVAHAGEDAI" FT CDS 216811..217203 FT /transl_table=11 FT /gene="furB" FT /locus_tag="Rv2359" FT /product="PROBABLE FERRIC UPTAKE REGULATION PROTEIN FURB" FT /function="ACTS AS A GLOBAL NEGATIVE CONTROLLING ELEMENT, FT EMPLOYING FE(2+) AS A COFACTOR TO BIND THE OPERATOR OF THE FT REPRESSED GENES. REGULATES THE EXPRESSION OF SEVERAL FT OUTER-MEMBRANE PROTEINS INCLUDING THE IRON TRANSPORT OPERON FT (BY SIMILARITY)." FT /note="Rv2359, (MTCY27.21c), len: 130 aa. Probable furB, FT ferric uptake regulation protein, equivalent to FT FURB|ML0824|Q9CCG6 PUTATIVE FERRIC UPTAKE REGULATORY FT PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: FT opt: 765, E(): 1.7e-43, (86.9% identity in 130 aa overlap). FT Also highly similar to FERRIC UPTAKE REGULATION PROTEINS FT e.g. Q9L2H5|SCC121.11 PUTATIVE METAL UPTAKE REGULATION FT PROTEIN from Streptomyces coelicolor (139 aa), FASTA FT scores: opt: 547, E(): 3.4e-29, (59.4% identity in 133 aa FT overlap); P06975|FUR_ECOLI from Escherichia coli (148 aa), FT FASTA scores: opt: 322, E(): 1.9e-14, (37.9% identity in FT 132 aa overlap); P45599|FUR_KLEPN FERRIC UPTAKE REGULATION FT PROTEIN from Klebsiella pneumoniae (155 aa), FASTA scores: FT opt: 314, E(): 6.7e-14, (36.35% identity in 132 aa FT overlap); etc. BELONGS TO THE FUR FAMILY." FT /db_xref="GOA:O05839" FT /db_xref="InterPro:IPR002481" FT /db_xref="PDB:2O03" FT /db_xref="UniProtKB/TrEMBL:O05839" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08464.1" FT /translation="MSAAGVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLT FT TVYRTLQSMASSGLVDTLHTDTGESVYRRCSEHHHHHLVCRSCGSTIEVGDHEVEAWAA FT EVATKHGFSDVSHTIEIFGTCSDCRS" FT CDS complement(217311..217739) FT /transl_table=11 FT /locus_tag="Rv2360c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2360c, (MTCY27.20), len: 142 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O05838" FT /protein_id="CAB08463.1" FT /translation="MPSLPDRLASILRDVLPAEEEPDGALTVRHDGTFASLRVVSIAED FT LELVSLTQILAWDLPLTKRLAEQVAKQARDINFGSVSLREKVSEKAARRSSGRPASNTA FT DVMLRYNFPGTGLTDDALRTLILLVLETGATIRSALVG" FT CDS complement(217739..218629) FT /transl_table=11 FT /locus_tag="Rv2361c" FT /standard_name="uppS" FT /product="LONG (C50) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE FT (Z-DECAPRENYL DIPHOSPHATE SYNTHASE)" FT /function="INVOLVED IN THE SYNTHESIS OF DECAPRENYL FT DIPHOSPHATE, A MOLECULE WHICH HAS A CENTRAL ROLE IN THE FT BIOSYNTHESIS OF MOST FEATURES OF THE MYCOBACTERIAL CELL FT WALL. ADDS SEVEN MORE ISOPRENE UNITS TO OMEGA,E, Z-FARNESYL FT DIPHOSPHATE AND RELEASES DECAPRENYL DIPHOSPHATE." FT /EC_number="2.5.1.-" FT /note="Rv2361c, (MT2430, MTCY27.19), len: 296 aa. Long FT (C50) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.-) FT (see citation below), equivalent to FT UPPS_MYCLE|ML0634|B1937_F2_65|P38119 UNDECAPRENYL FT PYROPHOSPHATE SYNTHETASE from Mycobacterium leprae (296 FT aa), FASTA scores: opt: 1789, E(): 1.8e-97, (86.5% identity FT in 296 aa overlap). Also highly similar to others e.g. FT UPPS|Q9L2H4 UNDECAPRENYL PYROPHOSPHATE SYNTHETASE from FT Streptomyces coelicolor (277 aa), FASTA scores: opt: 1098, FT E(): 8.2e-60, (63.5% identity in 247 aa overlap); FT Q55482|UPPS_SYNY3|SLL0506 from Synechocystis sp. strain PCC FT 6803 (249 aa), FASTA scores: opt: 686, E(): 4.2e-33, (46.4% FT identity in 235 aa overlap); O67291|UPPS_AQUAE|AQ_1248 from FT Aquifex aeolicus (231 aa), FASTA scores: opt: 684, E(): FT 5.2e-33, (46.3% identity in 229 aa overlap); etc. Also FT similar to Rv1086|MTV017.39 from Mycobacterium FT tuberculosis. Contains PS01066 Hypothetical YBR002c family FT signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY. FT Note that previously known as uppS." FT /db_xref="GOA:P60479" FT /db_xref="InterPro:IPR018520" FT /db_xref="PDB:2VG2" FT /db_xref="UniProtKB/Swiss-Prot:P60479" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08462.1" FT /translation="MARDARKRTSSNFPQLPPAPDDYPTFPDTSTWPVVFPELPAAPYG FT GPCRPPQHTSKAAAPRIPADRLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVIDIA FT CGAIELGIKWLSLYAFSTENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWVGSR FT PRLWRSVINELAVAEEMTKSNDVITINYCVNYGGRTEITEATREIAREVAAGRLNPERI FT TESTIARHLQRPDIPDVDLFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWA FT ACEEYASRTRRFGSA" FT misc_feature complement(217856..217912) FT /note="PS01066 Hypothetical YBR002c family signature" FT CDS complement(218622..219419) FT /transl_table=11 FT /locus_tag="Rv2362c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2362c, (MTCY27.18), len: 265 aa. Conserved FT hypothetical protein, equivalent to the Mycobacterium FT leprae proteins Q49754|B1937_F1_25 Hypothetical protein FT (269 aa), FASTA scores: opt: 1561, E(): 8.5e-93, (86.6% FT identity in 268 aa overlap); and Q9CCN0|ML0633 Hypothetical FT protein (268 aa), FASTA scores: opt: 1560, E(): 8.5e-93, FT (86.6% identity in 268 aa overlap). Also highly similar to FT Q9L2H3|SCC121.13c HYPOTHETICAL 27.1 KDA PROTEIN from FT Streptomyces coelicolor (251 aa), FASTA scores: opt: 843, FT E(): 6.9e-47, (52.2% identity in 249 aa overlap); ans FT similar to other hypothetical proteins. Weak similarity FT with P42095|RECO_BACSU DNA REPAIR PROTEIN RECOMBINASE from FT Bacillus subtilis (255 aa), FASTA scores: opt: 270, E(): FT 3.6e-10, (26.4% identity in 182 aa overlap). MAY BE RECO, FT MODULATING ASSEMBLY AND DISASSEMBLY OF RECA FILAMENTS (WITH FT RECF|Rv0003 AND RECR|Rv3715c). (see citation below)" FT /db_xref="GOA:P65983" FT /db_xref="InterPro:IPR003717" FT /db_xref="UniProtKB/Swiss-Prot:P65983" FT /protein_id="CAB08461.1" FT /translation="MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTRS FT KFGARLEPFAHIEVQLHPGRNLDIVTQVVSVDAFATDIVADYGRYTCGCAILETAERLA FT GEERAPAPALHRLTVGALRAVADGQRPRDLLLDAYLLRAMGIAGWAPALTECARCATPG FT PHRAFHIATGGSVCAHCRPAGSTTPPLGVVDLMSALYDGDWEAAEAAPQSARSHVSGLV FT AAHLQWHLERQLKTLPLVERFYQADRSVAERRAALIGQDIAGG" FT CDS 219481..220935 FT /transl_table=11 FT /gene="amiA2" FT /locus_tag="Rv2363" FT /product="PROBABLE AMIDASE AMIA2 (AMINOHYDROLASE)" FT /function="GENERATES MONOCARBOXYLATE FROM MONOCARBOXYLIC FT ACID AMIDE [CATALYTIC ACTIVITY: A MONOCARBOXYLIC ACID AMIDE FT + H(2)O = A MONOCARBOXYLATE + NH(3)]." FT /EC_number="3.5.1.4" FT /note="Rv2363, (MTCY27.17c), len: 484 aa. Probable amiA2, FT amidase (EC 3.5.1.4), highly similar or similar to others FT e.g. O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE from FT Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 777, FT E(): 1.1e-38, (35.0% identity in 474 aa overlap); FT Q55424|AMID_SYNY3|SLL0828 PUTATIVE AMIDASE from FT Synechocystis sp. strain PCC 6803 (506 aa), FASTA scores: FT opt: 770, E(): 3e-38, (36.4% identity in 456 aa overlap); FT Q53116|AMDA ENANTIOMERASE-SELECTIVE AMIDASE from FT Rhodococcus sp. (462 aa), FASTA scores: opt: 701, E(): FT 3.5e-34, (32.7% identity in 468 aa overlap); etc. Also FT highly similar to others from Mycobacterium tuberculosis FT e.g. FT AMI2_MYCTU|AMIB2|Q11056|Rv1263|MT1301|MTCY50.19c|cy50.19c FT AMIDASE (462 aa), FASTA scores: opt: 1141, E(): 2.9e-60, FT (45.4% identity in 454 aa overlap); etc. Contains PS00571 FT Amidases signature, and PS00017 ATP/GTP-binding site motif FT A (P-loop). BELONGS TO THE AMIDASE FAMILY." FT /db_xref="GOA:P63490" FT /db_xref="HSSP:1M21" FT /db_xref="InterPro:IPR000120" FT /db_xref="UniProtKB/Swiss-Prot:P63490" FT /protein_id="CAB08460.1" FT /translation="MVGASGSDAGAISGSGNQRLPTLTDLLYQLATRAVTSEELVRRSL FT RAIDVSQPTLNAFRVVLTESALADAAAADKRRAAGDTAPLLGIPIAVKDDVDVAGVPTA FT FGTQGYVAPATDDCEVVRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWSRRHT FT PGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPAAWTHLVGIKPQRGRISTWPLPEAFNG FT VTVNGVLARTVEDAALVLDAASGNVEGDRHQPPPVTVSDFVGIAPGPLKIALSTHFPYT FT GFRAKLHPEILAATQRVGDQLELLGHTVVKGNPDYGLRLSWNFLARSTAGLWEWAERLG FT DEVTLDRRTVSNLRMGHVLSQAILRSARRHEAADQRRVGSIFDIVDVVLAPTTAQPPPM FT ARAFDRLGSFGTDRAIIAACPSTWPWNLLGWPSINVPAGFTSDGLPIGVQLMGPANSEG FT MLISLAAELEAVSGWATKQPQVWWTS" FT misc_feature 219862..219885 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 219973..220068 FT /note="PS00571 Amidases signature" FT CDS complement(220932..221834) FT /transl_table=11 FT /gene="era" FT /locus_tag="Rv2364c" FT /standard_name="bex" FT /product="PROBABLE GTP-BINDING PROTEIN ERA" FT /function="BINDS BOTH GDP AND GTP. HAS AN INTRINSIC GTPASE FT ACTIVITY AND IS ESSENTIAL FOR CELL GROWTH." FT /note="Rv2364c, (MT2433, MTCY27.16), len: 300 aa. Probable FT era, GTP-binding protein, equivalent to FT Q49768|ERA_MYCLE|ML0631|B1937_F3_102 GTP-BINDING PROTEIN FT ERA HOMOLOG from Mycobacterium leprae (300 aa) FASTA FT scores: opt: 1589, E(): 3.4e-88, (81.4% identity in 301 aa FT overlap). Also highly similar to other GTP-binding proteins FT e.g. Q9RDF2|ERA_STRCO|SCC77.06 from Streptomyces coelicolor FT (317 aa), FASTA scores: opt: 1264, E(): 1.1e-68, (64.0% FT identity in 306 aa overlap); Q9KD52|ERA_BACHD|BH1367|BEX FT from Bacillus halodurans (304 aa), FASTA scores: opt: 869, FT (44.8% identity in 297 aa overlap); Q9KIH7|ERA_LACLA|ERAL FT from Lactococcus lactis (subsp. lactis) (Streptococcus FT lactis), and Lactococcus lactis (subsp. cremoris) FT (Streptococcus cremoris) (303 aa), FASTA scores: opt: 781, FT E(): 9.4e-40, (40.25% identity in 298 aa overlap); etc. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT BELONGS TO THE ERA/TRME FAMILY OF GTP-BINDING PROTEINS, ERA FT SUBFAMILY. Note that previously known as bex." FT /db_xref="GOA:P0A562" FT /db_xref="HSSP:1MKY" FT /db_xref="InterPro:IPR005225" FT /db_xref="UniProtKB/Swiss-Prot:P0A562" FT /protein_id="CAE55479.1" FT /translation="MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAI FT RGIVHSDDFQIILVDTPGLHRPRTLLGKRLNDLVRETYAAVDVIGLCIPADEAIGPGDR FT WIVEQLRSTGPANTTLVVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTGDRV FT DLLIDVLAAALPAGPAYYPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEV FT SPREGRDDLIDVHAALYVERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLR FT VKVAKNWQRDPKQLGRLGF" FT misc_feature complement(221775..221798) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(221908..222249) FT /transl_table=11 FT /locus_tag="Rv2365c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2365c, (MTCY27.15), len: 113 aa. Conserved FT hypothetical protein, highly similar to FT Q49767|ML0630|B1937_F3_101|CAC30138 Hypothetical protein FT from Mycobacterium leprae (108 aa), FASTA scores: opt: 426, FT E(): 1.4e-18, (67.9% identity in 106 aa overlap). Also FT highly similar to Q9RDF3|SCC77.05 from Streptomyces FT coelicolor (132 aa), FASTA scores: opt: 254, E(): 1.9e-18, FT (53.1% identity in 96 aa overlap). Equivalent to AAK46728 FT from Mycobacterium tuberculosis strain CDC1551 (93 aa) but FT longer 20 aa." FT /db_xref="UniProtKB/TrEMBL:O05833" FT /protein_id="CAB08458.1" FT /translation="MMRRPITLAEQLDAEDAKLVVLARAAMARAEAGAGAAVRDVDGRT FT YAAAPVALSALELTGLQAAVAAAVSSGATGLQAAVLVAGSVDDPGIAAVRELAPTAAII FT VTDRAGNPL" FT CDS complement(222221..223528) FT /transl_table=11 FT /locus_tag="Rv2366c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2366c, (MTCY27.14), len: 435 aa. Probable FT conserved transmembrane protein, highly similar to FT Q9L2L3|SCC117.07 PUTATIVE MEMBRANE PROTEIN from FT Streptomyces coelicolor (358 aa), FASTA scores: opt: 1159, FT E(): 5.5e-64, (53.0% identity in 353 aa overlap); ans FT similar to hypothetical proteins and hemolysin-related FT proteins e.g. Q9HN02|HLP|VNG2308G HEMOLYSIN PROTEIN from FT Halobacterium sp. strain NRC-1 (457 aa), FASTA scores: opt: FT 623, E(): 6.2e-31, (28.4% identity in 433 aa overlap); etc. FT Potential transmembrane protein with 2 CBS domains. BELONGS FT TO THE UPF0053 FAMILY." FT /db_xref="GOA:P67130" FT /db_xref="InterPro:IPR002550" FT /db_xref="UniProtKB/Swiss-Prot:P67130" FT /protein_id="CAB08473.1" FT /translation="MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPG FT AGSLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASF FT VVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFA FT SEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQA FT MTLAVRSGHSRIPVIGENVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPD FT SKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVED FT LGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRL FT HAEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG" FT CDS complement(223525..224073) FT /transl_table=11 FT /locus_tag="Rv2367c" FT /product="UNKNOWN" FT /function="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Rv2367c, (MTCY27.13), len: 182 aa. Conserved FT hypothetical protein, equivalent to FT Q49752|YN67_MYCLE|ML0628|B1937_F1_21 HYPOTHETICAL 19.8 KDA FT PROTEIN from Mycobacterium leprae (178 aa), FASTA scores: FT opt: 1051, E(): 2e-59, (89.1% identity in 175 aa overlap). FT Also highly similar to others e.g. Q9L2L4|SCC117.06 FT CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor FT (165 aa), FASTA scores: opt: 599, E(): 6e-31, (56.5% FT identity in 154 aa overlap); Q9KD56|BH1363 HYPOTHETICAL FT PROTEIN from Bacillus halodurans (159 aa), FASTA scores: FT opt: 311, E(): 8.3e-13, (45.05% identity in 111 aa FT overlap); etc." FT /db_xref="GOA:P67134" FT /db_xref="InterPro:IPR002036" FT /db_xref="UniProtKB/Swiss-Prot:P67134" FT /protein_id="CAB08472.1" FT /translation="MREHLMSIEVANESGIDVSEAELVSVARFVIAKMDVNPCAELSML FT LLDTAAMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPSMLGDIVLCPEFAAE FT QAAAAGHSLGHELALLTIHGVLHLLGYDHAEPDEEKEMFALQDRLLEEWVADQVEAYQH FT DRQDEKDRRLLDKSRYFDL" FT CDS complement(224077..225135) FT /transl_table=11 FT /gene="phoH1" FT /locus_tag="Rv2368c" FT /standard_name="phoH" FT /product="PROBABLE PHOH-LIKE PROTEIN PHOH1 (PHOSPHATE FT STARVATION-INDUCIBLE PROTEIN PSIH)" FT /function="FUNCTION NOT REALLY KNOWN." FT /note="Rv2368c, (MTCY27.12), len: 352 aa. Probable phoH1, FT phoH-like protein (phosphate starvation-induced protein), FT probably ATP-binding protein, equivalent to FT Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-LIKE PROTEIN FT from Mycobacterium leprae (349 aa), FASTA scores: opt: FT 1952, E(): 4.7e-107, (88.9% identity in 352 aa overlap). FT Also highly similar to Q9L2L5|SCC117.05 PHOH-LIKE PROTEIN FT from Streptomyces coelicolor (359 aa), FASTA scores: opt: FT 1407, E(): 3.6e-75, (63.6% identity in 349 aa overlap); FT Q9RSY1|DR1988 PHOH-RELATED PROTEIN from Deinococcus FT radiodurans (380 aa), FASTA scores: opt: 1053, E(): FT 1.9e-54, (53.3% identity in 349 aa overlap); FT Q9KD58|PHOH|BH1361 PHOSPHATE STARVATION-INDUCED PROTEIN FT from Bacillus halodurans (320 aa), FASTA scores: opt: 1019, FT E(): 1.6e-52, (54.35% identity in 300 aa overlap); FT P46343|PHOL_BACSU PHOH-LIKE PROTEIN from Bacillus subtilis FT (319 aa), FASTA scores: opt: 1014, E(): 3.2e-52, (50.8% FT identity in 303 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOH FT FAMILY. Note that previously known as phoH." FT /db_xref="GOA:P0A5S0" FT /db_xref="InterPro:IPR003714" FT /db_xref="UniProtKB/Swiss-Prot:P0A5S0" FT /protein_id="CAE55480.1" FT /translation="MTSRETRAADAAGARQADAQVRSSIDVPPDLVVGLLGSADENLRA FT LERTLSADLHVRGNAVTLCGEPADVALAERVISELIAIVASGQSLTPEVVRHSVAMLVG FT TGNESPAEVLTLDILSRRGKTIRPKTLNQKRYVDAIDANTIVFGIGPAGTGKTYLAMAK FT AVHALQTKQVTRIILTRPAVEAGERLGFLPGTLSEKIDPYLRPLYDALYDMMDPELIPK FT LMSAGVIEVAPLAYMRGRTLNDAFIVLDEAQNTTAEQMKMFLTRLGFGSKVVVTGDVTQ FT IDLPGGARSGLRAAVDILEDIDDIHIAELTSVDVVRHRLVSEIVDAYARYEEPGSGLNR FT AARRASGARGRR" FT misc_feature complement(224665..224688) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(225107..225409) FT /transl_table=11 FT /locus_tag="Rv2369c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2369c, (MTCY27.11), len: 100 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O05829" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08470.1" FT /translation="MIVGLADRHGHGRDVAAHRQAQLAGPRVAAVRRHRTGGHRQASSR FT IKVSAHGLGVVRCAPTPSLTGVRMKLQHSSVRQVPVDRPESRHQKPGDVPRDPRC" FT CDS complement(225406..226719) FT /transl_table=11 FT /locus_tag="Rv2370c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2370c, (MTCY27.10), len: 437 aa. Conserved FT hypothetical protein, member of family proteins from FT Mycobacterium tuberculosis with Rv1453|MTCY493_01c|O06807 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (432 aa), FASTA scores: opt: 1943, E(): FT 9.4e-115, (69.9% identity in 409 aa overlap); FT Rv1194c|MTCI364.06c; etc. Also similar to AAK45764|MT1500 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis strain CDC1551 (432 aa), FASTA scores: opt: FT 1934, E(): 9.4e-115, (69.9% identity in 409 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O05828" FT /protein_id="CAB08469.1" FT /translation="MVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRATLAAHPSIAA FT DPALATVVSRANRSHLIHFATANLRKPGQPVPANLGPDPLRMARDLVRRGLDASALDVY FT RVGQNVAWQRWTEIAFGLTTDPQELHELLTLPFRSASEFIDATLAGLAAQMQLEYDELT FT RDVHAEHRRIVELILDGAPISRQSAEAKLGYPLDRSHTAAIIWYDDPDDNQNHLDHTAR FT AFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIHQVLDHAPHARIAVGTTARGIDG FT FRRSHRDALATQRMLARLRSQQRLAFFADIHMIAVLTENPDSAADFITSTLGDLESASP FT QLLTTVLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVAISAL FT QWRGSQTSDPVETPVEGITSPPPESLGRRRSRLAQLER" FT CDS 226914..227099 FT /transl_table=11 FT /gene="PE_PGRS40" FT /locus_tag="Rv2371" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv2371, (MTCY27.09c), len: 61 aa. Short protein, FT member of the Mycobacterium tuberculosis PE family, PGRS FT subfamily of gly-rich proteins (see citation below), highly FT similar to N-terminal part of others e.g. AAK44356|MT0132 FT PE_PGRS FAMILY PROTEIN from Mycobacterium tuberculosis FT strain CDC1551 (561 aa), FASTA scores: opt: 217, E( ): FT 4.9e-08, (69.65% identity in 56 aa overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FE9" FT /protein_id="CAE55481.1" FT /translation="MSLVSVAPELVVTAVPDVARIGSSIGAPDTAAAARPTTSVLAAGA FT DEVSADVVALFGWVAR" FT CDS complement(227198..227986) FT /transl_table=11 FT /locus_tag="Rv2372c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2372c, (MTCY27.08), len: 262 aa. Conserved FT hypothetical protein, equivalent to Q9CCN1|ML0626 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (257 aa), FT FASTA scores: opt: 1277, E(): 3e-71, (77.25% identity in FT 255 aa overlap). Also highly similar to others e.g. FT Q9RDD9|SDRD HYPOTHETICAL 26.1 KDA PROTEIN from Streptomyces FT coelicolor (249 aa), FASTA scores: opt: 624, E(): 3.2e-31, FT (45.05% identity in 253 aa overlap); P54461|YQEU_BACSU FT hypothetical 28.8 kDa protein from Bacillus subtilis (256 FT aa), FASTA scores: opt: 375, E(): 6e-16, (32.5% identity in FT 234 aa overlap); etc. C-terminal half highly similar to FT Q49763|B1937_F2_57 from Mycobacterium leprae (128 aa), FT FASTA scores: opt: 577, E(): 1.4e-28, (75.8% identity in FT 124 aa overlap). BELONGS TO THE UPF0088 FAMILY." FT /db_xref="GOA:P67202" FT /db_xref="InterPro:IPR006700" FT /db_xref="UniProtKB/Swiss-Prot:P67202" FT /protein_id="CAB08467.1" FT /translation="MVAMLFYVDTLPDTGAVAVVDGDEGFHAATVRRIRPGEQLVLGDG FT VGRLARCVVEQAGRGGLRARVLRRWSVPPVRPPVTVVQALPKSERSELAIELATEAGAD FT AFLAWQAARCVANWDGARVDKGLRRWRAVVRSAARQSRRARIPPVDGVLSTPMLVQRVR FT EEVAAGAAVLVLHEEATERIVDIAAAQAGSLMLVVGPEGGIAPDELAALTDAGAVAVRL FT GPTVLRTSTAAAVALGAVGVLTSRWDASASDCEYCDVTRR" FT CDS complement(228000..229148) FT /transl_table=11 FT /gene="dnaJ2" FT /locus_tag="Rv2373c" FT /product="PROBABLE CHAPERONE PROTEIN DNAJ2" FT /function="ACTS AS A CO-CHAPERONE. STIMULATES, JOINTLY WITH FT GRPE, THE ATPASE ACTIVITY OF DNAK|Rv0350." FT /note="Rv2373c, (MTCY27.07), len: 382 aa. Probable dnaJ2, FT chaperone protein, equivalent to FT Q49762|DNJ2_MYCLE|ML0625|B1937_F2_56 CHAPERONE PROTEIN from FT Mycobacterium leprae (378 aa), FASTA scores: opt: 2301, FT E(): 1.7e-120, (87.5% identity in 382 aa overlap). Also FT highly similar to OTHER CHAPERONE PROTEINS DNAJ/DNAJ2 e.g. FT Q9RDD7|DNJ2_STRCO|SCC77.21c from Streptomyces coelicolor FT (378 aa), FASTA scores: opt: 1456, E(): 1.2e-73, (54.8% FT identity in 385 aa overlap); O52164|DNJ2_STRAL from FT Streptomyces albus (379 aa) FASTA scores: opt: 1378, E(): FT 2.6e-69, (52.2% identity in 385 aa overlap); FT Q9S5A3|DNAJ_LISMO from Listeria monocytogenes (377 aa), FT FASTA scores: opt: 1013, E(): 4.6e-49, (41.3% identity in FT 385 aa overlap); etc. Also similar to Rv0352|MTCY13E10.12 FT from Mycobacterium tuberculosis. Contains 1 J domain and 1 FT CR domain. BELONGS TO THE DNAJ FAMILY." FT /db_xref="GOA:P63966" FT /db_xref="HSSP:1HDJ" FT /db_xref="InterPro:IPR001305" FT /db_xref="UniProtKB/Swiss-Prot:P63966" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08479.1" FT /translation="MARDYYGLLGVSKNASDADIKRAYRKLARELHPDVNPDEAAQAKF FT KEISVAYEVLSDPDKRRIVDLGGDPLESAAAGGNGFGGFGGLGDVFEAFFGGGFGGGAA FT SRGPIGRVRPGSDSLLRMRLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSVPIPCD FT TCGGRGEVQTVQRSLLGQMLTSRPCPTCRGVGVVIPDPCQQCMGDGRIRARREISVKIP FT AGVGDGMRVRLAAQGEVGPGGGPAGDLYVEVHEQAHDVFVREGDHLHCTVSVPMVDAAL FT GVTVTVDAILDGLSEITIPPGTQPGSVITLRGRGMPHLRSNTRGDLHVHVEVVVPTRLD FT HQDIELLRELKGRRDREVAEVRSTHAAAGGLFSRLRETFTGR" FT CDS complement(229223..230254) FT /transl_table=11 FT /gene="hrcA" FT /locus_tag="Rv2374c" FT /product="PROBABLE HEAT SHOCK PROTEIN TRANSCRIPTIONAL FT REPRESSOR HRCA" FT /function="INVOLVED IN TRANSCRIPTIONAL REGULATION FT (REPRESSION) OF CLASS I HEAT SHOCK PROTEINS e.g. FT DNAK-GRPE-DNAJ1 AND GROELS OPERONS). PREVENTS HEAT-SHOCK FT INDUCTION OF THESE OPERONS." FT /note="Rv2374c, (MTCY27.06), len: 343 aa. Probable hrcA, FT heat-inducible transcriptional repressor (see citation FT below), equivalent to Q9CCN2|HRCA|ML0624 PUTATIVE FT HEAT-INDUCIBLE TRANSCRIPTIONAL REGULATOR from Mycobacterium FT leprae (343 aa), FASTA scores: opt: 1926, E(): 3.9e-107, FT (89.8% identity in 343 aa overlap). Also highly similar to FT other heat-inducible transcription repressor proteins e.g. FT Q9RDD6|HRCA|SCC77.22c from Streptomyces coelicolor (338 FT aa), FASTA scores: opt: 1227, E(): 1.1e-65, (58.8% identity FT in 335 aa overlap); O52163|HRCA_STRAL from Streptomyces FT albus (338 aa), FASTA scores: opt: 1196, E(): 7.7e-64, FT (56.1% identity in 335 aa overlap); P25499|HRCA_BACSU FT HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR from Bacillus FT subtilis (343 aa), FASTA scores: opt: 538, E(): 8.4e-25, FT (28.9% identity in 325 aa overlap); etc. Almost identical, FT but conflict at C-terminus, to Q49749|YGRP|B1937_F1_18 FT PUTATIVE HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR from FT Mycobacterium leprae (197 aa) FASTA scores: opt: 1126, E(): FT 6.9e-60, (91.8% identity in 195 aa overlap). BELONGS TO THE FT HRCA FAMILY." FT /db_xref="GOA:P64398" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P64398" FT /protein_id="CAB08478.1" FT /translation="MGSADERRFEVLRAIVADFVATQEPIGSKSLVERHNLGVSSATVR FT NDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLEDVKPLSSAERRAIQSFLESGVDL FT DDVLRRAVRLLAQLTRQVAVVQYPTLSTSTVRHLEVIALTPARLLMVVITDSGRVDQRI FT VELGDVIDDHQLAQLREILGQALEGKKLSAASVAVADLASQLGGAGGLGDAVGRAATVL FT LESLVEHTEERLLLGGTANLTRNAADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTV FT RIGHETASEQMVGTSMVSTAYGTAHTVYGGMGVVGPTRMDYPGTIASVAAVALYIGDVL FT GAR" FT CDS 230426..230743 FT /transl_table=11 FT /locus_tag="Rv2375" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2375, (MTCY27.05c), len: 105 aa. Conserved FT hypothetical protein, highly similar to only FT CAC32314|2SCD60.09c CONSERVED HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor (98 aa), FASTA scores: opt: 425, FT E(): 5.7e-24, (63.25% identity in 98 aa overlap)." FT /db_xref="InterPro:IPR014447" FT /db_xref="UniProtKB/TrEMBL:O05823" FT /protein_id="CAB08477.1" FT /translation="MIFKGVREGKPYPEHGLSYRDWSQIPPQQIRLDELVTTTTVLALD FT RLLSEDSTFYGDLFPHAVKWRGTTYLEDGLHRAVRAALRNRTVLHARVFDMDASPGGRR FT S" FT CDS complement(230770..231276) FT /transl_table=11 FT /gene="cfp2" FT /locus_tag="Rv2376c" FT /standard_name="mtb12" FT /product="LOW MOLECULAR WEIGHT ANTIGEN CFP2 (LOW MOLECULAR FT WEIGHT PROTEIN ANTIGEN 2) (CFP-2)" FT /function="FUNCTION NOT KNOWN (PUTATIVE SECRETED PROTEIN); FT MAY PLAY A ROLE IN THE DEVELOPMENT OF PROTECTIVE IMMUNE FT RESPONSES." FT /note="Rv2376c, (MT2445, MTCY27.04), len: 168 aa. cfp2 FT (alternate gene name: mtb12), low molecular weight antigen, FT secreted protein similar to FT Q49771|MB12_MYCLE|ML0620|B1937_F3_91 LOW MOLECULAR WEIGHT FT ANTIGEN MTB12 HOMOLOG PRECURSOR from Mycobacterium leprae FT (167 aa), FASTA scores: opt: 682, E(): 1.7e-32, (65.5% FT identity in 165 aa overlap). BELONGS TO THE MTB12 FAMILY." FT /db_xref="GOA:P0A5P8" FT /db_xref="InterPro:IPR020235" FT /db_xref="UniProtKB/Swiss-Prot:P0A5P8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08476.1" FT /translation="MKMVKSIAAGLTAAAAIGAAAAGVTSIMAGGPVVYQMQPVVFGAP FT LPLDPASAPDVPTAAQLTSLLNSLADPNVSFANKGSLVEGGIGGTEARIADHKLKKAAE FT HGDLPLSFSVTNIQPAAAGSATADVSVSGPKLSSPVTQNVTFVNQGGWMLSRASAMELL FT QAAGN" FT CDS complement(231376..231591) FT /transl_table=11 FT /gene="mbtH" FT /locus_tag="Rv2377c" FT /product="PUTATIVE CONSERVED PROTEIN MBTH" FT /function="THOUGHT TO BE INVOLVED IN THE BIOGENESIS OF THE FT HYDROXYPHENYLOXAZOLINE-CONTAINING SIDEROPHORE MYCOBACTINS." FT /note="Rv2377c, (MT2445.1, MTCY27.03), len: 71 aa. Putative FT mbtH, conserved protein with no function assigned (see FT Quadri et al ., 1998; De Voss et al., 1999), similar to FT hypothetical proteins or proteins found in several gene FT clusters for biosynthesis or transport of siderophores and FT other nonribosomally synthesized peptides e.g. FT Q9Z388|SCE8.11c PUTATIVE SMALL CONSERVED HYPOTHETICAL FT PROTEIN from Streptomyces coelicolor (71 aa), FASTA scores: FT opt: 345, E(): 1.4e-19, (68.2% identity in 66 aa overlap); FT Q9F8V3|CUMB COUY PROTEIN (probably involved in the FT biosynthesis of aminocoumarin antibiotic coumermycin A(1)) FT (see Wang et al., 2000) from Streptomyces rishiriensis (71 FT aa), FASTA scores: opt: 329, E(): 2.2e-18, (63.2% identity FT in 68 aa overlap); Q9F5J2|SIM-CB MBTH-LIKE PROTEIN FT (probably protein involved in the biosynthesis of FT aminocoumarin antibiotic coumermycin A(1)) from FT Streptomyces antibioticus (70 aa), FASTA scores: opt: 308, FT E(): 8.4e-17, (65.6% identity in 64 aa overlap); Q9FB14 FT MBTH-LIKE PROTEIN (involved in the biosynthesis of the FT antitumor drug bleomycin) (see Du et al., 2000) from FT Streptomyces verticillus FASTA scores: opt: 220, E(): FT 8.8e-10, (41.2% identity in 68 aa overlap); etc." FT /db_xref="InterPro:IPR005153" FT /db_xref="PDB:2KHR" FT /db_xref="UniProtKB/Swiss-Prot:O05821" FT /protein_id="CAB08480.1" FT /translation="MSTNPFDDDNGAFFVLVNDEDQHSLWPVFADIPAGWRVVHGEASR FT AACLDYVEKNWTDLRPKSLRDAMVED" FT CDS complement(231569..232864) FT /transl_table=11 FT /gene="mbtG" FT /locus_tag="Rv2378c" FT /product="LYSINE-N-OXYGENASE MBTG (L-LYSINE FT 6-MONOOXYGENASE) (LYSINE N6-HYDROXYLASE)" FT /function="INVOLVED IN THE BIOGENESIS OF THE FT HYDROXYPHENYLOXAZOLINE-CONTAINING SIDEROPHORE MYCOBACTINS. FT THIS HYDROXYLASE IS POSSIBLY REQUIRED FOR N-HYDROXYLATION FT OF THE TWO LYSINE RESIDUES AT SOME STAGE DURING MYCOBACTIN FT ASSEMBLY [CATALYTIC ACTIVITY: L-LYSINE + O(2) = FT N6-HYDROXY-L-LYSINE + H(2)O. NO INFORMATION CAN BE FOUND IF FT THIS ENZYME IS NADPH DEPENDENT OR INDEPENDENT]." FT /EC_number="1.14.13.59" FT /note="deleted EC_number 1.13.12.10" FT /note="Rv2378c, (MTCY27.02), len: 431 aa. mbtG, FT lysine-N-oxygenase (hydroxylase) (EC 1.13.12.10 or FT 1.14.13.59; depending if enzyme is NADPH dependent or FT independent) (see citations below), showing some similarity FT with various proteins including ornithine and FT lysine-N-oxygenases, e.g. Q9K6Q1|TRKA|BH3677 POTASSIUM FT UPTAKE PROTEIN from Bacillus halodurans (350 aa), FASTA FT scores: opt: 153, E(): 0.016, (25.2% identity in 246 aa FT overlap); P56584|SID1_USTMA L-ORNITHINE 5-MONOOXYGENASE (EC FT 1.13.12.-) from Ustilago maydis (Smut fungus) (570 aa), FT FASTA scores: opt: 136, E(): 0.31, (22.85% identity in 127 FT aa overlap); Q9HHV0|HXYA|VNG6214G MONOOXYGENASE from FT Halobacterium sp. strain NRC-1 (477 aa), FASTA scores: opt: FT 119, E(): 3.4, (40.0% identity in 70 aa overlap); FT O69828|SC1A6.23 PUTATIVE LYSINE N-HYDROXLASE (FRAGMENT) FT from Streptomyces coelicolor (134 aa), BLAST score: 76 FT (similarity in part for this one); etc. COFACTORS: FAD (BY FT SIMILARITY)." FT /db_xref="GOA:O05820" FT /db_xref="UniProtKB/Swiss-Prot:O05820" FT /protein_id="CAB08475.1" FT /translation="MNPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGAN FT WQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAE FT WIDRGRPAPTHRRWSQYLAWVADHIGLKVIHGEVERLAVTGDRWALCTHETTVQADALM FT ITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGGGETAASMLNELFRHR FT VSTITVISPQVTLFTRGEGFFENSLFSDPTDWAALTFDERRDALARTDRGVFSATVQEA FT LLADDRIHHLRGRVAHAVGRQGQIRLTLSTNRGSENFETVHGFDLVIDGSGADPLWFTS FT LFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSC FT LGLLSDRVLGAGIFTPTKHNDTRRSGEHQSFR" FT CDS complement(232861..237246) FT /transl_table=11 FT /gene="mbtF" FT /locus_tag="Rv2379c" FT /product="PEPTIDE SYNTHETASE MBTF (PEPTIDE SYNTHASE)" FT /function="INVOLVED IN THE BIOGENESIS OF THE FT HYDROXYPHENYLOXAZOLINE-CONTAINING SIDEROPHORE MYCOBACTINS. FT PROBABLY ACTIVATES THE TWO LYSINE RESIDUES THAT ARE FT INCORPORATED INTO MYCOBACTIN (LYSINE LIGATION)." FT /note="Rv2379c, (MTCY27.01), len: 1461 aa. mbtF, peptide FT synthetase (see citations below), similar in part to FT several synthases e.g. O52820|PCZA363.4 PROTEIN from FT Amycolatopsis orientalis (4077 aa), FASTA scores: opt: FT 1873, E(): 1.1e-99, (35.55% identity in 1522 aa overlap); FT O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from FT Streptomyces pristinaespiralis (4848 aa), FASTA scores: FT opt: 1817, E(): 2.1e-96, (33.65% identity in 1463 aa FT overlap); O52821 PROTEIN SIMILAR TO PEPTIDE SYNTHETASE from FT Amycolatopsis orientalis (1860 aa) FASTA scores: opt: 1705, FT E(): 2.9e-90, (34.75% identity in 1344 aa overlap); FT Q9XCF2|PSTB PUTATIVE PEPTIDE SYNTHETASE (similar to FT Mycobacterium tuberculosis nrp protein) from Mycobacterium FT avium (2552 aa), FASTA scores: opt: 1687, E(): 4e-89, FT (35.45% identity in 1058 aa overlap); Q9ZET7 PEPTIDE FT SYNTHETASE (FRAGMENT) from Mycobacterium smegmatis (1438 FT aa), FASTA scores: opt: 1479, E(): 2.5e-77, (30.45% FT identity in 1507 aa overlap); etc. Contains PS00455 FT putative AMP-binding domain signature. BELONGS TO THE FT ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:O05819" FT /db_xref="HSSP:1AMU" FT /db_xref="InterPro:IPR010071" FT /db_xref="UniProtKB/TrEMBL:O05819" FT /protein_id="CAB08474.1" FT /translation="MGPVAVTRADARGAIDDVMALSPLQQGLFSRATLVAAESGSEAAE FT ADPYVIAMAADAAGPLDIALLRDCAAAMLTRHPNLRASFLHGNLSRPVQVIPSSAEVLW FT RHVRAHPSEVGALAAEERRRRFDVGRGPLIRFLLIELPDECWHLVIVAHHIVIDGWSLP FT LFVSELLALYRAGGHVAALPAAPRPYRDYIGWLAGRDQTASRAMWADHLNGLDGPTLLS FT PALADTPVQPGIPGRTEVRLDREATAELADAARTRGVTISTLVQMAWATTLSAFTGRGD FT VTFGVTVSGRPSELSGVETMIGLFINTVPLRVRLDARATVGGQCAVLQRQFAMLRDHSY FT LGFNEFRAIAGIGEMFDTLLVYENFPPGEVVGTAEFVANGVTFRPVALESLSHFPVTVA FT AHRSTGELTLLVEVLDGALGTMAPESLGRRVLAVLQRLVSRWDRPLRDVDILLDGEHDP FT TAPGLPDVTTSAPAVHTRFAEIAAAQPDSVAVSWADGQLTYRELDALADRLATGLRRAD FT VSRETPVAVALSRGPRYVAAMLAVLKAGGMIVPLDPAMPGERVAEILRQTSAPVVIDEG FT VFAASVGADILEEDRAITVPVDQAAYVIFTSGTTGTPKGVIGTHRALSAYADDHIERVL FT RPAAQRLGRPLRIAHAWSFTFDAAWQPLVALLDGHAVHIVDDHRQRDAGALVEAIDRFG FT LDMIDTTPSMFAQLHNAGLLDRAPLAVLALGGEALGAATWRMIQQNCARTAMTAFNCYG FT PTETTVEAVVAAVAEHARPVIGRPTCTTRAYVMDSWLRPVPDGVAGELYLAGAQLTRGY FT LGRPAETAARFVAEPNGRGSRMYRTGDVVRRLPDGGLEFLGRSDDQVKIRGFRVEPGEI FT AAVLNGHHAVHGCHVTARGHASGPRLTAYVAGGPQPPPVAELRAMLLERLPRYLVPHHI FT VVLDELPLTPHGKIDENALAAINVTEGPATPPQTPTELVLAEAFADVMETSNVDVTAGF FT LQMGLDSIVALSVVQAARRRGIALRARLMVECDTIRELAAAIDSDAAWQAPANDAGEPI FT PVLPNTHWLYEYGDPRRLAQTEVIRLPDRITRERLDAVLAAVVDGHEVLRCRFDRDAMA FT LVAQPKTDILSEVWVSGELVTAVAEQTLGALASLDPQAGRLLSAVWLREPDGPGVLVLT FT AHVLAMDPASWRIVLGELDAGLHALAAGRAPSPARENTSYRQWSRLLAQRAKALDSVDF FT WVAELEGADPPLGARRVAPQTDRVGELAITMSISDADLTARLLSTGRSMTDLLATAAAR FT MVTAWRRQRGQQTPAPLLALETHGRADVHVDKTADTSDTVGLLSAIYPLRIHCDGATDF FT ARIPGSGIDYGLLRYLRADTAERLRAHREPQLLLNYLGSLHVGVGDLAVDRALLADVGQ FT LPEPEQPVRHELTVLAALLGPADAPVLATRWRTLPDILSADDVATLQSLWQGALAEITA FT " FT misc_feature complement(235405..235440) FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(237228..242276) FT /transl_table=11 FT /gene="mbtE" FT /locus_tag="Rv2380c" FT /product="PEPTIDE SYNTHETASE MBTE (PEPTIDE SYNTHASE)" FT /function="INVOLVED IN THE BIOGENESIS OF THE FT HYDROXYPHENYLOXAZOLINE-CONTAINING SIDEROPHORE MYCOBACTINS. FT PROBABLY ACTIVATES THE TWO LYSINE RESIDUES THAT ARE FT INCORPORATED INTO MYCOBACTIN (LYSINE LIGATION)." FT /note="Rv2380c, (MTCY22H8.05), len: 1682 aa. mbtE, peptide FT synthetase (see citations below), similar in part to FT several synthases e.g. O07944|SNBDE PRISTINAMYCIN I FT SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 FT aa), FASTA scores: opt: 2635, E(): 1.9e-146, (36.8% FT identity in 1657 aa overlap); O05647|SNBDE VIRGINIAMYCIN S FT SYNTHETASE (FRAGMENT) from Streptomyces virginiae (1997 aa) FT FASTA scores: opt: 2580, E(): 1.6e-143, (40.65% identity in FT 1163 aa overlap); Q9R9I2|DHBF PROTEIN INVOLVED IN FT SIDEROPHORE PRODUCTION from Bacillus subtilis (2378 aa), FT FASTA scores: opt: 2388, E(): 3.6e-132, (33.9% identity in FT 1579 aa overlap); O68487|ACMB ACTINOMYCIN SYNTHETASE II FT from Streptomyces chrysomallus (2611 aa), FASTA scores: FT opt: 2165, E(): 4.9e-119, (35.0% identity in 1634 aa FT overlap); etc. Equivalent to AAK46743 from Mycobacterium FT tuberculosis strain CDC1551 (1787 aa) but shorter 105 aa. FT Contains PS00455 putative AMP-binding domain signature, and FT PS00012 Phosphopantetheine attachment site. BELONGS TO THE FT ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:O86329" FT /db_xref="HSSP:1AMU" FT /db_xref="InterPro:IPR010071" FT /db_xref="UniProtKB/TrEMBL:O86329" FT /protein_id="CAB08481.1" FT /translation="MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRIL FT RTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDA FT PLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAA FT SGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMA FT KNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQ FT SAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGG FT FNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVL FT LDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV FT VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYV FT PVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYT FT SGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGA FT RMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEP FT LPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLD FT DSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNAD FT GDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPA FT AGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIAS FT DTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDV FT GVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNA FT VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCA FT AGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLF FT TDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAG FT ETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKA FT GGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYA FT HQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFD FT AAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVE FT MVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSET FT ATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETE FT RALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCE FT LAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQWP" FT misc_feature complement(239334..239381) FT /note="PS00012 Phosphopantetheine attachment site" FT misc_feature complement(240525..240560) FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(242416..245430) FT /transl_table=11 FT /gene="mbtD" FT /locus_tag="Rv2381c" FT /product="POLYKETIDE SYNTHETASE MBTD (POLYKETIDE SYNTHASE)" FT /function="INVOLVED IN THE BIOGENESIS OF THE FT HYDROXYPHENYLOXAZOLINE-CONTAINING SIDEROPHORE MYCOBACTINS." FT /note="Rv2381c, (MTCY22H8.04), len: 1004 aa. mbtD, FT polyketide synthase (see citations below), similar in part FT to several synthases e.g. Q03132|ERY2_SACER|ERYA FT ERYTHRONOLIDE SYNTHASE, MODULES 3 AND 4 (EC 2.3.1.94) from FT Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 FT aa), FASTA scores: opt: 971, E(): 1e-46, (29.35% identity FT in 1043 aa overlap); Q9F829|MEGAII MEGALOMICIN FT 6-DEOXYERYTHRONOLIDE B SYNTHASE 2 from Micromonospora FT megalomicea subsp. nigra (3562 aa), FASTA scores: opt: 787, FT E(): 2.4e-36, (29.35% identity in 1032 aa overlap); FT Q9L4W4|NYSB POLYKETIDE SYNTHASE from Streptomyces noursei FT (3192 aa), FASTA scores: opt: 761, E(): 6.6e-35, (29.55% FT identity in 1086 aa overlap); O30764|NIDA1 POLYKETIDE FT SYNTHASE MODULES 1 AND 2 from Streptomyces caelestis (4340 FT aa), FASTA scores: opt: 726, E(): 7.8e-33, (27.3% identity FT in 1052 aa overlap); etc. Contains PS00012 FT Phosphopantetheine attachment site." FT /db_xref="GOA:P71719" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P71719" FT /protein_id="CAB03758.1" FT /translation="MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEV FT ARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQ FT GGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIE FT GAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGR FT LPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSG FT HFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYW FT YANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSA FT RRGERFVDALSANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEP FT LPPVSGLTIAVERWERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSA FT ARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVD FT AADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETA FT LRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRI FT VLLSRRAADQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSV FT ISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSA FT ANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQ FT QAIEASLHEFTVDPLVFAADAARLQMLLDSRQFERYEGPTDPNLTIVDAVRTQLAAVLG FT IPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDA FT DERSHTAQKVDISRD" FT misc_feature complement(242551..242598) FT /note="PS00012 Phosphopantetheine attachment site" FT CDS complement(245430..246764) FT /transl_table=11 FT /gene="mbtC" FT /locus_tag="Rv2382c" FT /product="POLYKETIDE SYNTHETASE MBTC (POLYKETIDE SYNTHASE)" FT /function="INVOLVED IN THE BIOGENESIS OF THE FT HYDROXYPHENYLOXAZOLINE-CONTAINING SIDEROPHORE MYCOBACTINS." FT /note="Rv2382c, (MTCY22H8.03), len: 444 aa. mbtC, FT polyketide synthase (see citations below), similar in part FT to several synthases e.g. Q9F7T9 AVERMECTIN POLYKETIDE FT SYNTHASE (FRAGMENT) from Streptomyces avermitilis (3626 FT aa), FASTA scores: opt: 1458, E(): 7e-82, (50.65% identity FT in 446 aa overlap); AAG23264|SPNA POLYKETIDE SYNTHASE FT LOADING AND EXTENDER MODULE 1 from Saccharopolyspora FT spinosa (2595 aa) FASTA scores: opt: 1441, E(): 6e-81, FT (49.1% identity in 446 aa overlap); O33954|TYLG TYLACTONE FT SYNTHASE STARTER MODULE AND MODULES 1 & 2 from Streptomyces FT fradiae (4472 aa) FASTA scores: opt: 1439, E(): 1.2e-80, FT (51.0% identity in 447 aa overlap); O30764|NIDA1 POLYKETIDE FT SYNTHASE MODULES 1 AND 2 from Streptomyces caelestis (4340 FT aa) FASTA scores: opt: 1432, E(): 3.3e-80, (50.9% identity FT in 442 aa overlap); etc." FT /db_xref="GOA:P71718" FT /db_xref="InterPro:IPR014030" FT /db_xref="UniProtKB/TrEMBL:P71718" FT /protein_id="CAB03757.1" FT /translation="MSDNDPVVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDRG FT WALRELFDGSRRNGFKPIHNLGGFLSSATTFDPEFFRISPREATAMDPQQRVGLRVAWR FT TLENSGINPDDLAGHDVGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIAYTL FT DLAGPALTVDTSCSSALAAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQHALS FT DDGHCRPYSAHASGTAWAEGAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLSDGLTA FT PSGDAQTRLLRRAIAQAAVVPADVGMVEGHGTATRLGDRTELRSLAASYGTAPAGRGPL FT LGSVKSNIGHAQAAAGGLGLVKVILAAQHAAIPPTLHVDEPSREIDWEKQGLRLADKLT FT PWRAVDGWRTAAVSAFGMSGTNSHVIVSMPDTVSAPERGPECGEV" FT CDS complement(246754..250998) FT /transl_table=11 FT /gene="mbtB" FT /locus_tag="Rv2383c" FT /product="PHENYLOXAZOLINE SYNTHASE MBTB (PHENYLOXAZOLINE FT SYNTHETASE)" FT /function="INVOLVED IN THE BIOGENESIS OF THE FT HYDROXYPHENYLOXAZOLINE-CONTAINING SIDEROPHORE MYCOBACTINS. FT THIS PEPTIDE SYNTHASE FORMS AMIDE BOUND BETWEEN THE FT CARBOXYLIC ACID OF SALICYLATE AND THE ALPHA-AMINO GROUP OF FT SERINE (SERINE/THREONINE LIGATION)." FT /note="Rv2383c, (MTCY22H8.02), len: 1414 aa. mbtB, FT phenyloxazoline synthase (see citations below), similar to FT the N-terminal region of several synthetases e.g. FT Q9EWP5|SC4C2.17 PUTATIVE NON-RIBOSOMAL PEPTIDE SYNTHASE FT from Streptomyces coelicolor (2229 aa), FASTA scores: opt: FT 2878, E(): 4.1e-156, (46.85% identity in 1138 aa overlap); FT Q9Z399|IRP2 YERSINIABACTIN BIOSYNTHETIC from Yersinia FT pestis (2041 aa), FASTA scores: opt: 2297, E(): 5.3e-123, FT (38.55% identity in 1069 aa overlap); FT P48633|HMP2_YEREN|IRP2 HIGH-MOLECULAR-WEIGHT PROTEIN 2 (MAY FT BE INVOLVED IN THE NONRIBOSOMAL SYNTHESIS OF SMALL FT PEPTIDES) from Yersinia enterocolitica (2035 aa), FASTA FT scores: opt: 2275, E(): 9.4e-122, (38.45% identity in 1069 FT aa overlap); O85739|PCHE|PA4226 DIHYDROAERUGINOIC ACID FT SYNTHETASE from Pseudomonas aeruginosa (1438 aa) FASTA FT scores: opt: 2236, E(): 1.2e-119, (38.2% identity in 1330 FT aa overlap); Q9RFM8|PCHE PYOCHELIN SYNTHETASE from FT Pseudomonas aeruginosa (1438 aa), FASTA scores: opt: 2229, FT E(): 3e-119, (38.0% identity in 1329 aa overlap); etc. FT Contains PS00455 Putative AMP-binding domain signature, and FT PS00012 Phosphopantetheine attachment site. BELONGS TO THE FT ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:P71717" FT /db_xref="HSSP:1DNY" FT /db_xref="InterPro:IPR001031" FT /db_xref="UniProtKB/Swiss-Prot:P71717" FT /protein_id="CAB03756.1" FT /translation="MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSL FT VGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAP FT MQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGT FT QRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGER FT TRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGYTYREYRQAIEAEETLPQPVRD FT ADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPA FT MTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTA FT AARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTE FT QFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLA FT AGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSG FT DLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVD FT QPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAY FT VLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADRWLALATLECDMSVLDIFAAL FT RSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGGGRLSSLRAVAVG FT GDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFP FT NNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLA FT RYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPGVHAAAATVLPGGSDVLAAAV FT CVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERS FT GDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRW FT LDSPSLMVADMFAARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPI FT EQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQR FT ADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGHCMGAIVA |