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EBI DbfetchID BX842578; SV 1; linear; genomic DNA; STD; PRO; 346186 BP. XX AC BX842578; AL021899; AL021922; AL021924; AL022020; AL022073; Z73966; Z74025; AC Z78020; Z83859; Z84498; Z95388; Z97193; Z97559; Z97984; XX DT 21-NOV-2003 (Rel. 77, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 7/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-346186 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF00005; tRNA. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..346186 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT CDS complement(226..1086) FT /transl_table=11 FT /locus_tag="Rv1833c" FT /product="Possible haloalkane dehalogenase" FT /function="May act on a wide range of 1-haloalkanes, FT haloalcohols, haloalkenes and some haloaromatic compounds FT [Catalytic activity: 1-haloalkane + H(2)O, a primary FT alcohol + halide]" FT /EC_number="3.8.1.5" FT /note="Rv1833c, (MTCY1A11.10), len: 286 aa. Possible FT haloalkane dehalogenase (EC 3.8.1.5). Similar to several FT haloalkane dehalogenase e.g. CAB45532.1|AJ243259 from FT Mycobacterium bovis (300 aa); also similar to FT LINB_PSEPA|P51698 1,3,4,6-tetrachloro-1,4-cyclohexadien FT from Pseudomonas paucimobilis (295 aa), FASTA scores: opt: FT 314, E(): 1.5e-13, (33.1% identity in 281 aa overlap)." FT /db_xref="GOA:P64303" FT /db_xref="HSSP:1CV2" FT /db_xref="InterPro:IPR000639" FT /db_xref="UniProtKB/Swiss-Prot:P64303" FT /protein_id="CAB01469.1" FT /translation="MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPT FT WSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGLDRYL FT SMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRR FT NFFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVP FT ATLGTKPTLLIWGMKDVAFRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAI FT IERFG" FT CDS 1127..1993 FT /transl_table=11 FT /locus_tag="Rv1834" FT /product="Probable hydrolase" FT /function="UNKNOWN" FT /EC_number="3.-.-.-" FT /note="Rv1834, (MTCY1A11.09c), len: 288 aa. Probable FT hydrolase (EC 3.-.-.-), some similarity to haloalkane FT dehalogenases and D16262 hypothetical 38.9 kDa protein (335 FT aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity FT in 300 aa overlap)." FT /db_xref="GOA:Q50599" FT /db_xref="InterPro:IPR000639" FT /db_xref="UniProtKB/Swiss-Prot:Q50599" FT /protein_id="CAB01468.1" FT /translation="MTSPSVREWRDGGRWLPTAVGKVFVRSGPGDTPTMLLLHGYPSSS FT FDFRAVIPHLTGQAWVTMDFLGFGLSDKPRPHRYSLLEQAHLVETVVAHTVTGAVVVLA FT HDMGTSVTTELLARDLDGRLPFDLRRAVLSNGSVILERASLRPIQKVLRSPLGPVAARL FT VSRGGFTRGFGRIFSPAHPLSAQEAQAQWELLCYNDGNRIPHLLISYLDERIRHAQRWH FT GAVRDWPKPLGFVWGLDDPVATTNVLNGLRELRPSAAVVELPGLGHYPQVEAPKAYAEA FT ALSLLVD" FT CDS complement(1998..3884) FT /transl_table=11 FT /locus_tag="Rv1835c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1835c, (MTCY1A11.08), len: 628 aa. Conserved FT hypothetical protein, some similarity to putative acylases FT e.g. G216374 glutaryl 7-aca acylase precursor (634 aa) FT FASTA scores, opt: 202, E(): 3.5e-06, (25.1% identity in FT 669 aa overlap). Also similar to Mycobacterium tuberculosis FT hypothetical proteins Rv2800 and Rv1215c." FT /db_xref="GOA:P0A5F5" FT /db_xref="InterPro:IPR000383" FT /db_xref="UniProtKB/Swiss-Prot:P0A5F5" FT /protein_id="CAB01467.1" FT /translation="MTRRGGSDAAWYSAPDQRSAYPRYRGMRYSSCYVTMRDGVRIAID FT LYLPAGLTSAARLPAILHQTRYYRSLQLRWPLRMLLGGKPLQHIAADKRRRRRFVASGY FT AWVDVDVRGSGASFGARVCEWSSDEIRDGAEIVDWIVRQPWCNGTVAALGNSYDGTSAE FT LLLVNQHPAVRVIAPCFSLFDVYTDIAFPGGIHAAWFTDTWGRYNEALDRNALHEVVGW FT WAKLPVTGMQPVQEDRDRSLRDGAIAAHRGNYDVHQIAGSLTFRDDVSASDPYRGQPDA FT RLEPIGTPIESGSINLISPHNYWRDVQASGAAIYSYSGWFDGGYAHAAIKRFLTVSTPG FT SHLILGPWNHTGGWRVDPLRGLSRPDFDHDGELLRFIDHHVKGADTGIGSEPPVHYFTM FT VENRWKSADTWPPPATTQSYYLSADRQLRPDAPDCDSGADEYVVDQTAGTGERSRWRSQ FT VGIGGHVCYPDRKAQDAKLLTYTSAPLDHPLEVTGHVVVTLFITSTSSDGTFFVYLEDV FT DPRGRVAYITEGQLRAIHRRLSDGPPPYRQVVPYRTFASGDAWPLVPGEIARLTFDLLP FT TSYLFQPGHRIRIAIAGADASHFAILPGCAPTVRVYRSRMHASRIDLPVIQP" FT CDS complement(3900..5933) FT /transl_table=11 FT /locus_tag="Rv1836c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1836c, (MTCY1A11.07), len: 677 aa. Conserved FT hypothetical protein. Equivalent to MLCB1788.28|AL008609 FT hypothetical protein from Mycobacterium leprae (710 aa), FT FASTA scores: opt: 2938, E(): 0, (66.0% identity in 714 aa FT overlap). Contains PS00036 bZIP transcription factors basic FT domain signature." FT /db_xref="GOA:Q50597" FT /db_xref="InterPro:IPR002035" FT /db_xref="UniProtKB/Swiss-Prot:Q50597" FT /protein_id="CAB01466.1" FT /translation="MGRHSKPDPEDSVDDLSDGHAAEQQHWEDISGSYDYPGVDQPDDG FT PLSSEGHYSAVGGYSASGSEDYPDIPPRPDWEPTGAEPIAAAPPPLFRFGHRGPGDWQA FT GHRSADGRRGVSIGVIVALVAVVVMVAGVILWRFFGDALSNRSHTAAARCVGGKDTVAV FT IADPSIADQVKESADSYNASAGPVGDRCVAVAVTSAGSDAVINGFIGKWPTELGGQPGL FT WIPSSSISAARLTGAAGSQAISDSRSLVISPVLLAVRPELQQALANQNWAALPGLQTNP FT NSLSGLDLPAWGSLRLAMPSSGNGDAAYLAGEAVAAASAPAGAPATAGIGAVRTLMGAR FT PKLADDSLTAAMDTLLKPGDVATAPVHAVVTTEQQLFQRGQSLSDAENTLGSWLPPGPA FT AVADYPTVLLSGAWLSQEQTSAASAFARYLHKPEQLAKLARAGFRVSDVKPPSSPVTSF FT PALPSTLSVGDDSMRATLADTMVTASAGVAATIMLDQSMPNDEGGNSRLSNVVAALENR FT IKAMPPSSVVGLWTFDGREGRTEVPAGPLADPVNGQPRPAALTAALGKQYSSGGGAVSF FT TTLRLIYQEMLANYRVGQANSVLVITAGPHTDQTLDGPGLQDFIRKSADPAKPIAVNII FT DFGADPDRATWEAVAQLSGGSYQNLETSASPDLATAVNIFLS" FT misc_feature complement(4377..4418) FT /note="PS00036 bZIP transcription factors basic domain FT signature" FT CDS complement(6053..8278) FT /transl_table=11 FT /gene="glcB" FT /locus_tag="Rv1837c" FT /product="PROBABLE MALATE SYNTHASE G GLCB" FT /function="INVOLVED IN GLYOXYLATE BYPASS (SECOND STEP), AN FT ALTERNATIVE TO THE TRICARBOXYLIC ACID CYCLE [CATALYTIC FT ACTIVITY : L-MALATE + CoA = ACETYL-CoA + H(2)O + FT GLYOXYLATE]" FT /EC_number="4.1.3.2" FT /note="Rv1837c, (MTCY1A11.06), len: 741 aa. Probable glcB, FT malate synthase G (EC 4.1.3.2) (see citations below), FT highly similar to MASY_CORGL|P42450 malate synthase (738 FT aa), FASTA score: opt: 2961, E(): 0, (61.3% identity in 724 FT aa overlap). BELONGS TO THE MALATE SYNTHASE G FAMILY." FT /db_xref="GOA:P0A5J4" FT /db_xref="InterPro:IPR006253" FT /db_xref="PDB:1N8I" FT /db_xref="UniProtKB/Swiss-Prot:P0A5J4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB01465.1" FT /translation="MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVAD FT LTPQNQALLNARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSG FT VDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKV FT RGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTG FT AAESPTSVLLINHGLHIEILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDA FT ADKVLGYRNWLGLNKGDLAAAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRN FT VGHLMTNDAIVDTDGSEVFEGIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPK FT MHGPAEVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINT FT GFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWT FT MTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIE FT QLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWVDQGVGCSKVPDIHDVALMEDRA FT TLRISSQLLANWLRHGVITSADVRASLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLA FT AQELILSGAQQPNGYTEPILHRRRREFKARAAEKPAPSDRAGDDAAR" FT CDS complement(8554..8949) FT /transl_table=11 FT /locus_tag="Rv1838c" FT /product="CONSERVED HYPOTHETICAL" FT /function="UNKNOWN" FT /note="Rv1838c, (MTCY359.35), len: 131 aa. Conserved FT hypothetical protein. Part of 14-membered Mycobacterium FT tuberculosis protein family with Rv2863|MTV003.09|AL008883 FT (126 aa), FASTA scores: opt: 293, E(): 1.5e-14, (38.2% FT identity in 123 aa overlap); Rv0749, Rv0277c, Rv2530c, etc. FT Also similar to AJ248288|CNSPAX06_181 Pyrococcus abyssi FT complete genome (136 aa), FASTA scores: opt: 197, E(): FT 2.2e-07, (33. 1% identity in 133 aa overlap)." FT /db_xref="InterPro:IPR006596" FT /db_xref="UniProtKB/Swiss-Prot:P64901" FT /protein_id="CAB06116.1" FT /translation="MILVDSNIPMYLVGASHPHKLDAQRLLESALSGGERLVTDAEVLQ FT EICHRYVAIKRREAIQPAFDAIIGVVDEVLPIERTDVEHARDALLRYQTLSARDALHIA FT VMAHHDITRLMSFDRGFDSYPGIKRLA" FT CDS complement(8946..9209) FT /transl_table=11 FT /locus_tag="Rv1839c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1839c, (MTCY359.34), len: 87 aa. Conserved FT hypothetical protein. Some similarity to G217008 CHO-ORF1 FT (279 aa), FASTA scores: opt: 86, E(): 13, (38.7% identity FT in 62 aa overlap). TBparse score is 1.006." FT /db_xref="GOA:P95167" FT /db_xref="UniProtKB/TrEMBL:P95167" FT /protein_id="CAB06115.1" FT /translation="MSKRLQVLLDPDEWEELREIARRHRTTVSEWVRRTLREAREREPR FT GDLDMKLRSVRAAARHEFPTADVEQMLEEIERGRGAEREGSR" FT CDS complement(9268..10815) FT /transl_table=11 FT /gene="PE_PGRS34" FT /locus_tag="Rv1840c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1840c, (MTCY359.33), len: 515 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below). Similar to many FT e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa FT protein (603 aa), FASTA scores: opt: 1693, E(): 0, (53.1% FT identity in 612 aa overlap); etc." FT /db_xref="GOA:Q50594" FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:Q50594" FT /protein_id="CAE55436.1" FT /translation="MSFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGAD FT EVSAAVADLFGAHAQAYQALSAQAALFHEQFVHAMTAGAGAYAGAEAADAAALDVLNGP FT FQALFGRPLIGDGANGAPGQPGGPGGLLYGNGGNGGNGGIGQPGGAGGDAGLIGNGGNG FT GIGGPGATGLAGGAGGVGGLLFGDGGNGGAGGLGTGPVGATGGIGGPGGAAVGLFGHGG FT AGGAGGLGKAGFAGGAGGTGGTGGLLYGNGGNGGNVPSGAADGGAGGDARLIGNGGDGG FT SVGAAPTGIGNGGNGGNGGWLYGDGGSGGSTLQGFSDGGTGGNAGMFGDGGNGGFSFFD FT GNGGDGGTGGTLIGNGGDGGNSVQTDGFLRGHGGDGGNAVGLIGNGGAGGAGSAGTGVF FT APGGGSGGNGGNGALLVGNGGAGGSGGPTQIPSVAVPVTGAGGTGGNGGTAGLIGNGGN FT GGAAGVSGDGTPGTGGNGGYAQLIGDGGDGGPGDSGGPGGSGGTGGTLAGQNGSPGG" FT CDS complement(10978..12015) FT /transl_table=11 FT /locus_tag="Rv1841c" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1841c, (MTCY359.32), len: 345 aa. Conserved FT hypothetical membrane protein. Some similarity to FT O07585|YHDP_BACSU HYPOTHETICAL 49.9 kDa PROTEIN from FT Bacillus subtilis (444 aa), FASTA scores: opt: 620, E(): 0, FT (31.1% identity in 350 aa overlap). Also similar to other FT Mycobacterium tuberculosis proteins e.g. Rv1842c, Rv2366c." FT /db_xref="GOA:Q50593" FT /db_xref="InterPro:IPR002550" FT /db_xref="UniProtKB/Swiss-Prot:Q50593" FT /protein_id="CAB06113.1" FT /translation="MDVLSAVLLALLLIGANAFFVGAEFALISARRDRLEALAEQGKAT FT AVTVIRAGEQLPAMLTGAQLGVTVSSILLGRVGEPAVVKLLQLSFGLSGVPPALLHTLS FT LAIVVALHVLLGEMVPKNIALAGPERTAMLLVPPYLVYVRLARPFIAFYNNCANAILRL FT VGVQPKDELDIAVSTAELSEMIAESLSEGLLDHEEHTRLTRALRIRTRLVADVAVPLVN FT IRAVQVSAVGSGPTIGGVEQALAQTGYSRFPVVDRGGRFIGYLHIKDVLTLGDNPQTVI FT DLAVVRPLPRVPQSLPLADALSRMRRINSHLALVTADNGSVVGMVALEDVVEDLVGTMR FT DGTHR" FT CDS complement(12015..13382) FT /transl_table=11 FT /locus_tag="Rv1842c" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1842c, (MTCY359.31), len: 455 aa. Conserved FT hypothetical membrane protein. Similar to Z99109|0O7589 FT Potential integral membrane protein from Bacillus subtilis FT (461 aa), FASTA scores: opt: 723, E(): 0, (31.2% identity FT in 449 aa overlap). Similar to other Mycobacterium FT tuberculosis putative integral membrane proteins e.g. FT Rv2366c, Rv1841c. TBPARSE score is 0.883." FT /db_xref="GOA:Q50592" FT /db_xref="InterPro:IPR002550" FT /db_xref="UniProtKB/Swiss-Prot:Q50592" FT /protein_id="CAB06112.1" FT /translation="MNLTDTVATILAILALTAGTGVFVAAEFSLTALDRSTVEANARGG FT TSRDRFIQRAHHRLSFQLSGAQLGISITTLATGYLTEPLVAELPHPGLVAVGMSDRVAD FT GLITFFALVIVTSLSMVFGELVPKYLAVARPLRTARSVVAGQVLFSLLLTPAIRLTNGA FT ANWIVRRLGIEPAEELRSARTPQELVSLVRSSARSGALDDATAWLMRRSLQFGALTAEE FT LMTPRSKIVALQTDDTIADLVAAAAASGFSRFPVVEGDLDATVGIVHVKQVFEVPPGDR FT AHTLLTTVAEPVAVVPSTLDGDAVMAQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIV FT GDVRDEHDDATPDVVAAGNGWRVSGLLRIDEVASATGYRAPDGPYETIGGLVLRELGHI FT PVAGETVELTALDQDGLPDDSMRWLATVIQMDGRRIDLLELIKMGGHADPGSGRGR" FT CDS complement(13556..14995) FT /transl_table=11 FT /gene="guaB1" FT /locus_tag="Rv1843c" FT /product="PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE FT GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)" FT /function="INVOLVED IN GMP BIOSYNTHESIS [CATALYTIC FT ACTIVITY: Inosine 5'-phosphate + NAD+ + H2O = xanthosine FT 5'-phosphate + NADH]" FT /EC_number="1.1.1.205" FT /note="Rv1843c, (MTCY359.30), len: 479 aa. Probable guaB1, FT inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). FT Similar to others e.g. IMDH_BACSU|P21879 from Bacillus FT subtilis (513 aa), FASTA score: opt: 904, E(): 0, (37.8% FT identity in 471 aa overlap). Similar to other Mycobacterium FT tuberculosis proteins e.g. guaB2, Rv3411c. TBPARSE score is FT 0.883." FT /db_xref="GOA:P65172" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR005991" FT /db_xref="UniProtKB/Swiss-Prot:P65172" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06111.1" FT /translation="MMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGTT FT IPVVVANMTAVAGRRMAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTPVTLA FT PDDSVSDAMALIHKRAHGVAVVILEGRPIGLVRESSCLGVDRFTRVRDIAVTDYVTAPA FT GTEPRKIFDLLEHAPVDVAVLTDADGTLAGVLSRTGAIRAGIYTPATDSAGRLRIGAAV FT GINGDVGAKARALAEAGVDVLVIDTAHGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEG FT TRDLLKAGANVVKVGVGPGAMCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIR FT HPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTGA FT DNPFDRARKALFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVGASNLAELHER FT AVVGVQSGAGFAEGHPLPAGW" FT CDS complement(15028..16485) FT /transl_table=11 FT /gene="gnd1" FT /locus_tag="Rv1844c" FT /product="PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1" FT /function="INVOLVED IN HEXOSE MONOPHOSPHATE SHUNT (PENTOSE FT PHOSPHATE PATHWAY) [CATALYTIC ACTIVITY: FT 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + FT CO2 + NADPH]." FT /EC_number="1.1.1.44" FT /note="Rv1844c, (MTCY359.29), len: 485 aa. Probable gnd1, FT 6-phosphogluconate dehydrogenase (EC 1.1.1.44). Similar to FT others e.g. 6PGD_ECOLI|P00350 from Escherichia coli (468 FT aa), FASTA scores: opt: 1661, E(): 0, (53.6% identity in FT 466 aa overlap); etc. Also similar to FT Rv1122|MTCY22G8.11|gnd2 PROBABLE 6-PHOSPHOGLUCONATE FT DEHYDROGENASE, DECARBOXYLATING from Mycobacterium FT tuberculosis (340 aa), FASTA score: (33.0% identity in 351 FT aa overlap). Note that Rv1844c is most similar to gnd's FT from Gram negative organisms, while Rv1122|MTCY22G8.11|gnd2 FT is most similar to gnd's from Gram positive organisms. FT BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY. FT TBparse score is 0.886." FT /db_xref="GOA:Q79FJ2" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q79FJ2" FT /protein_id="CAE55437.1" FT /translation="MSSSESPAGIAQIGVTGLAVMGSNIARNFARHGYTVAVHNRSVAK FT TDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLIMVKAGEATDADAVINELADAMEPG FT DIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLG FT PLLEEISAHVDGVPCCTHIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAP FT AIADVFTEWNNGDLDSYLVEITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSAL FT DLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQPADPATFTEDVRQALYASKI FT VAYAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIV FT APYFRGAVESAIDSWRRVVSTAAQLGIPTPGFSSALSYYDALRTARLPAALTQAQRDFF FT GAHTYGRIDEPGKFHTLWSSDRTEVPV" FT CDS complement(16515..17465) FT /transl_table=11 FT /locus_tag="Rv1845c" FT /product="CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1845c, (MTCY359.28), len: 316 aa. Conserved FT hypothetical transmembrane protein. Equivalent to FT MLCB1788.18|AL008609 Hypothetical protein from FT Mycobacterium leprae (316 aa), FASTA scores: opt: 1762, FT E(): 0, (87.6% identity in 314 aa overlap). Similar to FT proteins in Streptomyces coelicolor e.g. FT SC10A7.04|AL078618.1. TBparse score is 0.901." FT /db_xref="GOA:P95164" FT /db_xref="InterPro:IPR001915" FT /db_xref="UniProtKB/TrEMBL:P95164" FT /protein_id="CAB06143.1" FT /translation="MSALAFTILAVLLAGPTPALLARATWPLRAPRAAMVLWQAIALAA FT VLSSFSAGIAIASRLLMPGPDGRPTTSFVGAAGRLGWPLWAAYITVFALTVLVGARLAV FT AVVRVATATRRRRAHHRMVVDLVGVGHNGALAQPCARARDLRVLDVAQPLAYCLPGVRS FT RVVVSEGTLTALADAEVAAILTHERAHLRARHDLVLEAFTAVHAAFPRLVRSANALGAV FT QLLVELLADDAAVRAAGRTPLARALVACASGRAPSGALAVGGPSTVLRVRRLSGRGNSA FT VLSAAAYLAAAAVLVVPTVALAVPWLTQLQRLFIA" FT CDS complement(17480..17896) FT /transl_table=11 FT /locus_tag="Rv1846c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv1846c, (MTCY359.27), len: 138 aa. Possible FT transcriptional regulatory protein. Equivalent to FT MLCB1788.17|AL008609 hypothetical protein from FT Mycobacterium leprae (142 aa), FASTA scores: opt: 736 E(): FT 0, (95.1% identity in 123 aa overlap). Also similar to FT BLAI_BACLI|P06555 penicillinase repressor (128 aa), fasta FT scores: opt: 114, E(): 0.12, (23.7% identity in 131 aa FT overlap). TBPARSE score is 0.921." FT /db_xref="GOA:P95163" FT /db_xref="InterPro:IPR011991" FT /db_xref="PDB:2G9W" FT /db_xref="UniProtKB/Swiss-Prot:P95163" FT /protein_id="CAB06141.1" FT /translation="MAKLTRLGDLERAVMDHLWSRTEPQTVRQVHEALSARRDLAYTTV FT MTVLQRLAKKNLVLQIRDDRAHRYAPVHGRDELVAGLMVDALAQAEDSGSRQAALVHFV FT ERVGADEADALRRALAELEAGHGNRPPAGAATET" FT CDS 18174..18596 FT /transl_table=11 FT /locus_tag="Rv1847" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1847, (MTCY359.26c), len: 140 aa. Conserved FT hypothetical protein, possible thioesterase, some FT similarity to YBDB proteins of Escherichia coli and H. FT influenzae e.g. P15050|YBDB_ECOLI HYPOTHETICAL 15.0 KD FT PROTEIN IN ENTA-CSTA INTERGENIC REGION (137 aa), FASTA FT scores: opt: 232, E(): 6.6e-10, (35.8% identity in 106 aa FT overlap); C48956|G142208 thioesterase from Arthrobacter sp FT (151 aa), FASTA score: opt: 254, E(): 1.7e-11, (33.3% FT identity in 138 aa overlap). Also similar to FT AF064959|AF064959_1 hypothetical protein from Coxiella FT burnetii (148 aa), FASTA score: opt: 264, E(): 9.3e- 12, FT (36.8% identity in 117 aa overlap). TBparse score is FT 0.903." FT /db_xref="HSSP:1O0I" FT /db_xref="InterPro:IPR006683" FT /db_xref="UniProtKB/Swiss-Prot:P95162" FT /protein_id="CAB06140.1" FT /translation="MQPSPDSPAPLNVTVPFDSELGLQFTELGPDGARAQLDVRPKLLQ FT LTGVVHGGVYCAMIESIASMAAFAWLNSHGEGGSVVGVNNNTDFVRSISSGMVYGTAEP FT LHRGRRQQLWLVTITDDTDRVVARGQVRLQNLEARP" FT CDS 18645..18947 FT /transl_table=11 FT /gene="ureA" FT /locus_tag="Rv1848" FT /product="Urease gamma subunit ureA (Urea amidohydrolase)" FT /function="INVOLVED IN THE CONVERSION OF UREA TO NH3 FT [CATALYTIC ACTIVITY: Urea + H2O = CO2 + 2 NH3]" FT /EC_number="3.5.1.5" FT /note="Rv1848, (MTCY359.25c), len: 100 aa. ureA, urease FT gamma subunit (EC 3.5.1.5). Similar to URE3_MYCTU|P50043 FT from Mycobacterium tuberculosis (100 aa), FASTA scores: FT opt: 630, E(): 1.3e-36, (99.0% identity in 100 aa overlap). FT TBPARSE score is 0.874. BELONGS TO THE UREASE GAMMA SUBUNIT FT FAMILY." FT /db_xref="GOA:P0A676" FT /db_xref="InterPro:IPR002026" FT /db_xref="PDB:2FVH" FT /db_xref="UniProtKB/Swiss-Prot:P0A676" FT /protein_id="CAB06139.1" FT /translation="MRLTPHEQERLLLSYAAELARRRRARGLRLNHPEAIAVIADHILE FT GARDGRTVAELMASGREVLGRDDVMEGVPEMLAEVQVEATFPDGTKLVTVHQPIA" FT CDS 18944..19258 FT /transl_table=11 FT /gene="ureB" FT /locus_tag="Rv1849" FT /product="Urease beta subunit ureB" FT /function="INVOLVED IN THE CONVERSION OF UREA TO NH3 FT [CATALYTIC ACTIVITY: Urea + H2O = CO2 + 2 NH3]" FT /EC_number="3.5.1.5" FT /note="Rv1849, (MTCY359.24c), len: 104 aa. ureB, urease FT beta subunit (EC 3.5.1.5). Identical to URE2_MYCTU|P50048 FT urease beta subunit from Mycobacterium tuberculosis (100 FT aa). TBPARSE score is 0.914. BELONGS TO THE UREASE GAMMA FT SUBUNIT FAMILY." FT /db_xref="GOA:P0A662" FT /db_xref="HSSP:1EJX" FT /db_xref="InterPro:IPR002019" FT /db_xref="UniProtKB/Swiss-Prot:P0A662" FT /protein_id="CAB06138.1" FT /translation="MIPGEIFYGSGDIEMNAAALSRLQMRIINAGDRPVQVGSHVHLPQ FT ANRALSFDRATAHGYRLDIPAATAVRFEPGIPQIVGLVPLGGRREVPGLTLNPPGRLDR FT " FT CDS 19258..20991 FT /transl_table=11 FT /gene="ureC" FT /locus_tag="Rv1850" FT /product="Urease alpha subunit ureC (Urea amidohydrolase)" FT /function="INVOLVED IN THE CONVERSION OF UREA TO NH3 FT [CATALYTIC ACTIVITY: Urea + H2O = CO2 + 2 NH3]" FT /EC_number="3.5.1.5" FT /note="Rv1850, (MTCY359.23c), len: 577 aa. ureC, urease FT alpha subunit (EC 3.5.1.5). Similar to URE1_MYCTU|P50042 FT from Mycobacterium tuberculosis (577 aa), FASTA scores: FT opt: 3794, E(): 0, (98.3% identity in 577 aa overlap). FT Contains PS00145 Urease active site motif. TBPARSE score is FT 0.898. BELONGS TO THE UREASE FAMILY." FT /db_xref="GOA:P0A660" FT /db_xref="HSSP:1EJX" FT /db_xref="InterPro:IPR017950" FT /db_xref="UniProtKB/Swiss-Prot:P0A660" FT /protein_id="CAB06137.1" FT /translation="MARLSRERYAQLYGPTTGDRIRLADTNLLVEVTEDRCGGPGLAGD FT EAVFGGGKVLRESMGQGRASRADGAPDTVITGAVIIDYWGIIKADIGIRDGRIVGIGKA FT GNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHVHLICPQIIVEALAAGTTTIIG FT GGTGPAEGTKATTVTPGEWHLARMLESLDGWPVNFALLGKGNTVNPDALWEQLRGGASG FT FKLHEDWGSTPAAIDTCLAVADVAGVQVALHSDTLNETGFVEDTIGAIAGRSIHAYHTE FT GAGGGHAPDIITVAAQPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLAFA FT ESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMKARRGALEGDP FT SGSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKLADLVLWEPAFFGVRPHVVL FT KGGAIAWAAMGDANASIPTPQPVLPRPMFGAAAATAAATSVHFVAPQSIDARLADRLAV FT NRGLAPVADVRAVGKTDLPLNDALPSIEVDPDTFTVRIDGQVWQPQPAAELPMTQRYFL FT F" FT misc_feature 20227..20277 FT /note="PS00145 Urease active site" FT CDS 20991..21626 FT /transl_table=11 FT /gene="ureF" FT /locus_tag="Rv1851" FT /product="Urease accessory protein uref" FT /function="PROBABLY FACILITATES NICKEL INCORPORATION" FT /note="Rv1851, (MTCY359.22c), len: 211 aa. ureF, urease FT accessory protein. Identical to UREF_MYCTU|P50050 from M. FT tuberculosis. TBPARSE score is 0.871." FT /db_xref="GOA:P50050" FT /db_xref="InterPro:IPR002639" FT /db_xref="UniProtKB/Swiss-Prot:P50050" FT /protein_id="CAB06136.1" FT /translation="MTSLAVLLTLADSRLPTGAHVHSGGIEEAIAAGMVTGLATLEAFL FT KRRVRTHGLLTASIAAAVHRGELAVDDADRETDARTPAPAARHASRSQGRGLIRLARRV FT WPDSGWEELGPRPHLAVVAGRVGALSGLAPEHNALHLVYITMTGSAIAAQRLLALDPAE FT VTVVTFQLSELCEQIAQEATAGLADLSDPLLDTLAQRHDERVRPLFVS" FT CDS 21637..22311 FT /transl_table=11 FT /gene="ureG" FT /locus_tag="Rv1852" FT /product="Urease accessory protein ureG" FT /function="PROBABLY FACILITATES NICKEL INCORPORATION" FT /note="Rv1852, (MTCY359.21c), len: 224 aa. ureG, urease FT accessory protein. Identical to UREG_MYCTU|P50051 from M. FT tuberculosis. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). BELONGS TO THE UREG FAMILY. TBPARSE score is FT 0.878." FT /db_xref="GOA:P0A664" FT /db_xref="InterPro:IPR004400" FT /db_xref="UniProtKB/Swiss-Prot:P0A664" FT /protein_id="CAB06135.1" FT /translation="MATHSHPHSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAAL FT CRQLRGELSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITANLD FT AIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDKVPRKGGPGVTYS FT DLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSLTEDPAASDVVAWVRSQLAAD FT GV" FT misc_feature 21730..21753 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 22319..22945 FT /transl_table=11 FT /gene="ureD" FT /locus_tag="Rv1853" FT /product="Probable urease accessory protein ureD" FT /function="PROBABLY FACILITATES NICKEL INCORPORATION" FT /note="Rv1853, (MTCY359.20c), len: 208 aa. ureD, probable FT urease accessory protein. Similar to URED_YEREN|P42868 FT Urease operon ureD protein from Yersinia enterocolitica FT (325 aa), Fasta scores: opt: 114, E(): 0.37, (25.2% FT identity in 119 aa overlap). TBPARSE score is 0.904." FT /db_xref="UniProtKB/TrEMBL:P95161" FT /protein_id="CAB06134.1" FT /translation="MVASPNRLPRIDCRGGVQARRTAPDTVHLVSAAATPLGGDTMRIR FT VIVERGAQLRLRSAAATVALPGVDTLTSHAHWEIDVTGTLDVDLEPTVVAASARHLSHA FT TLRLHDDGRVRLRERVQIGRCNEREGFWSSSLQADRHGRPLLRHRVELGAGSLADDVIA FT APRATISELRYPATAFTDAIDARSTVLALAGGGTLSTWQADRLPG" FT CDS complement(22948..24339) FT /transl_table=11 FT /gene="ndh" FT /locus_tag="Rv1854c" FT /product="PROBABLE NADH DEHYDROGENASE NDH" FT /function="TRANSFER OF ELECTRONS FROM NADH TO THE FT RESPIRATORY CHAIN. THE IMMEDIATE ELECTRON ACCEPTOR FOR THE FT ENZYME IS BELIEVED TO BE UBIQUINONE. DOES NOT COUPLE THE FT REDOX REACTION TO PROTON TRANSLOCATION." FT /EC_number="1.6.99.3" FT /note="Rv1854c, (MTCY359.19), len: 463 aa. Probable ndh, FT NADH dehydrogenase (EC 1.6.99.3) (see citations below), FT similar to several e.g. S74826 NADH dehydrogenase from FT Synechocystis sp. (445 aa), FASTA score: opt: 1228, E(): 0, FT (46.3% identity in 432 aa overlap). Highly similar to FT Rv0392c|Z84725|g1817703 from Mycobacterium tuberculosis FT (470 aa), FASTA scores: opt: 1911, E(): 0, (64.7% identity FT in 459 aa overlap); and Rv1812c. TBPARSE score is 0.897." FT /db_xref="GOA:P95160" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:P95160" FT /protein_id="CAB06133.1" FT /translation="MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIAR FT TTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSELL FT GHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERSSD FT PERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLP FT PMGAKLGQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVS FT ASRLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQGAIQGA FT KYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVL FT HLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAAS FT AKVAS" FT CDS complement(24481..25404) FT /transl_table=11 FT /locus_tag="Rv1855c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.-.-.-" FT /note="Rv1855c, (MTCY359.18), len: 307 aa. Possible FT oxidoreductase (EC 1.-.-.-), possibly a monooxygenase. FT Contains PS00217 Sugar transport proteins signature 2, FT probably fortuitously. Similar to G487716 (78-11) FT LINCOMYCIN PRODUCTION GENES (29.2% identity in 154 aa FT overlap). Also similar to other Mycobacterium tuberculosis FT proteins e.g. Rv0953c, Rv0791c, Rv0132c, Rv2951c, etc." FT /db_xref="GOA:P95159" FT /db_xref="InterPro:IPR019952" FT /db_xref="UniProtKB/TrEMBL:P95159" FT /protein_id="CAB06132.1" FT /translation="MTIRLGLQIPNFSYGTGVEKLFPSVIAQAREAEAAGYDSLFVMDH FT FYQLPMLGTPDQPMLEAYTALGALATATERLQLGALVTGNTYRSPTLLAKIITTLDVVS FT AGRAILGIGAGWFELEHRQLGFEFGTFSDRFNRLEEALQILEPMVKGERPTFFGDWYTT FT ESAMAEPRYRDRIPILIGGGGEKKTFAIAARFADHLNIVAAVDELPRKMRALAARCDEA FT GRDRSTLQTSLLLTVMIDETLSPDAIPAEMSGRVVVGSPAQIADQIQAKVLDAGVDGLI FT INLAPHGYLPGVITTAAEALRPLLGV" FT misc_feature complement(25003..25080) FT /note="PS00217 Sugar transport proteins signature 2" FT CDS complement(25443..26120) FT /transl_table=11 FT /locus_tag="Rv1856c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv1856c, (MTCY359.17), len: 225 aa. Possible FT oxidoreductase (EC 1.-.-.-). Equivalent to FT MLCB1788.11c|AL008609 OXIDOREDUCTASE from Mycobacterium FT leprae (224 aa), FASTA scores: opt: 1211, E(): 0; (80.4% FT identity in 224 aa overlap). Some similarity to FT dehydrogenases of short-chain dehydrogenase/reductase FT family and fatty-acyl CoA reductases e.g. P16543|DHK2_STRVN FT GRANATICIN POLYKETIDE SYNTHASE P (249 aa), FASTA score: FT opt: 194, E(): 1.1e-05, (32.5% identity in 237 aa FT overlap)." FT /db_xref="GOA:P95158" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95158" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06131.1" FT /translation="MAVEVLVTGGDTDLGRTMAEGFRNDGHKVTLVGARRGDLEVAAKE FT LDVDAVVCDTTDPTSLTEARGLFPRHLDTIVNVPAPSWDAGDPRAYSVSDTANAWRNAL FT DATVLSVVLTVQSVGDHLRSGGSIVSVVAENPPAGGAESAIKAALSNWIAGQAAVFGTR FT GITINTVACGRSVQTGYEGLSRTPAPVAAEIARLALFLTTPAARHITGQTLHVSHGALA FT HFG" FT CDS 26282..27067 FT /transl_table=11 FT /gene="modA" FT /locus_tag="Rv1857" FT /product="PROBABLE MOLYBDATE-BINDING LIPOPROTEIN MODA" FT /function="INVOLVED IN THE ACTIVE TRANSPORT OF MOLYBDENUM FT INTO THE CELL ACROSS THE MEMBRANE (IMPORT). PART OF THE FT BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM MODABC." FT /note="Rv1857, (MTCY359.16c), len: 261 aa. Probable modA, FT molybdate-binding protein attached to membrane by FT lipid-modified N-terminal cysteine (contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site), FT component of molybdate transport system (see citations FT below). Shows strong similarity to precursors of FT periplasmic molybdate/sulphate binding proteins e.g. FT O31229|Y10817|ANY108174 ModA from Arthrobacter FT nicotinovorans (260 aa), FASTA score: opt: 725, E(): 0, FT (47.8% identity in 249 aa overlap). TBparse score is FT 0.926." FT /db_xref="GOA:P0A5Y0" FT /db_xref="HSSP:1WOD" FT /db_xref="InterPro:IPR006059" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Y0" FT /protein_id="CAB06130.1" FT /translation="MRWIGLSTGLVSAMLVAGLVACGSNSPASSPAGPTQGARSIVVFA FT AASLQSAFTQIGEQFKAGNPGVNVNFAFAGSSELATQLTQGATADVFASADTAQMDSVA FT KAGLLAGHPTNFATNTMVIVAAAGNPKKIRSFADLTRPGLNVVVCQPSVPCGSATRRIE FT DATGIHLNPVSEELSVTDVLNKVITGQADAGLVYVSDALSVATKVTCVRFPEAAGVVNV FT YAIAVLKRTSQPALARQFVAMVTAAAGRRILDQSGFAKP" FT misc_feature 26315..26347 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 27070..27864 FT /transl_table=11 FT /gene="modB" FT /locus_tag="Rv1858" FT /product="PROBABLE MOLBDENUM-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER MODB" FT /function="PART OF THE BINDING-PROTEIN-DEPENDENT TRANSPORT FT SYSTEM MODABC FOR MOLYBDENUM; RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1858, (MTCY359.15c), len: 264 aa. Probable modB, FT molybdenum-transport integral membrane protein ABC FT transporter (see citation below), similar to others e.g. FT Y10817|ANY108175 ModB from Arthrobacter (239 aa), FASTA FT scores: opt: 937, E(): 0, (67.8% identity in 230 aa FT overlap); etc. Similar to other Mycobacterium tuberculosis FT transport proteins e.g. Rv2039c, Rv2316, etc. TBparse score FT is 0.911." FT /db_xref="GOA:P0A624" FT /db_xref="InterPro:IPR006469" FT /db_xref="UniProtKB/Swiss-Prot:P0A624" FT /protein_id="CAB06129.1" FT /translation="MHPPTDLPRWVYLPAIAGIVFVAMPLVAIAIRVDWPRFWALITTP FT SSQTALLLSVKTAAASTVLCVLLGVPMALVLARSRGRLVRSLRPLILLPLVLPPVVGGI FT ALLYAFGRLGLIGRYLEAAGISIAFSTAAVVLAQTFVSLPYLVISLEGAARTAGADYEV FT VAATLGARPGTVWWRVTLPLLLPGVVSGSVLAFARSLGEFGATLTFAGSRQGVTRTLPL FT EIYLQRVTDPDAAVALSLLLVVVAALVVLGVGARTPIGTDTR" FT CDS 27871..28980 FT /transl_table=11 FT /gene="modC" FT /locus_tag="Rv1859" FT /product="PROBABLE MOLYBDENUM-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER MODC" FT /function="PART OF THE BINDING-PROTEIN-DEPENDENT TRANSPORT FT SYSTEM MODABC FOR MOLYBDENUM; RESPONSIBLE FOR ENERGY FT COUPLING TO THE TRANSPORT SYSTEM." FT /note="Rv1859, (MTCY359.14c), len: 369 aa. Probable modC, FT molybdenum-transport ATP-binding protein ABC transporter FT (see citation below), similar to others e.g. FT Y10817|ANY108176 ModC from Arthrobacter (349 aa), FASTA FT scores: opt: 895, E(): 0, (46.0% identity in 361 aa FT overlap); etc. Shows similarity to other Mycobacterium FT tuberculosis ABC-transporter proteins e.g. Rv0073, Rv1238, FT Rv2564, etc. Contains both PS00017 ATP/GTP-binding site FT motif A (P-loop) and PS00211 ABC transporters family FT signatures involved in molybdate uptake. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). FT TBparse score is 0.918." FT /db_xref="GOA:P95155" FT /db_xref="HSSP:1L7V" FT /db_xref="InterPro:IPR005116" FT /db_xref="UniProtKB/Swiss-Prot:P95155" FT /protein_id="CAB06128.1" FT /translation="MSKLQLRAVVADRRLDVEFSVSAGEVLAVLGPNGAGKSTALHVIA FT GLLRPDAGLVRLGDRVLTDTEAGVNVATHDRRVGLLLQDPLLFPHLSVAKNVAFGPQCR FT RGMFGSGRARTRASALRWLREVNAEQFADRKPRQLSGGQAQRVAIARALAAEPDVLLLD FT EPLTGLDVAAAAGIRSVLRSVVARSGCAVVLTTHDLLDVFTLADRVLVLESGTIAEIGP FT VADVLTAPRSRFGARIAGVNLVNGTIGPDGSLRTQSGAHWYGTPVQDLPTGHEAIAVFP FT PTAVAVYPEPPHGSPRNIVGLTVAEVDTRGPTVLVRGHDQPGGAPGLAACITVDAATEL FT RVAPGSRVWFSVKAQEVALHPAPHQHASS" FT misc_feature 27961..27984 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 28285..28329 FT /note="PS00211 ABC transporters family signature" FT CDS 29033..30010 FT /transl_table=11 FT /gene="apa" FT /locus_tag="Rv1860" FT /standard_name="mpt32; modD" FT /product="ALANINE AND PROLINE RICH SECRETED PROTEIN APA FT (FIBRONECTIN ATTACHMENT PROTEIN) (Immunogenic protein FT MPT32) (Antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa FT antigen)" FT /function="UNKNOWN (COULD MEDIATE BACTERIAL ATTACHMENT TO FT HOST CELLS)." FT /note="Rv1860, (MT1908, MTCY359.0013), len: 325 aa. apa FT (alternate gene names: mpt32, modD), Ala-, Pro-rich 45/47 FT kDa secreted protein, very similar to P46842|N43L_MYCLE FT from Mycobacterium leprae (287 aa), FASTA scores: opt: FT 1166, E(): 0, (66.4% identity in 298 aa overlap). Known to FT be glycosylated fibronectin-binding protein (see some FT citations). CHANGES IN THE MANNOSYLATION PATTERN OF THIS FT PROTEIN AFFECT ITS ABILITY TO STIMULATE T-LYMPHOCYTE FT RESPONSE. MAJOR IMMUNODOMINANT ANTIGEN THAT HAS POTENTIAL FT AS A VACCINE AGAINST TUBERCULOSIS. APA-ELISA COULD BE USED FT IN DIAGNOSIS. TBparse score is 0.924." FT /db_xref="GOA:Q50906" FT /db_xref="InterPro:IPR010801" FT /db_xref="UniProtKB/Swiss-Prot:Q50906" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55438.1" FT /translation="MHQVDPNLTRRKGRLAALAIAAMASASLVTVAVPATANADPEPAP FT PVPTTAASPPSTAAAPPAPATPVAPPPPAAANTPNAQPGDPNAAPPPADPNAPPPPVIA FT PNAPQPVRIDNPVGGFSFALPAGWVESDAAHFDYGSALLSKTTGDPPFPGQPPPVANDT FT RIVLGRLDQKLYASAEATDSKAAARLGSDMGEFYMPYPGTRINQETVSLDANGVSGSAS FT YYEVKFSDPSKPNGQIWTGVIGSPAANAPDAGPPQRWFVVWLGTANNPVDKGAAKALAE FT SIRPLVAPPPAPAPAPAEPAPAPAPAGEVAPTPTTPTPQRTLPA" FT CDS 30462..30767 FT /transl_table=11 FT /locus_tag="Rv1861" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1861, (MTCY359.12c), len: 101 aa. Probable FT conserved transmembrane protein, showing weak similarity to FT AE002069|AE002069_10 hypothetical protein from Deinococcus FT radiodurans (146 aa), FASTA scores: opt: 154, E(): 0.0027, FT (30.8% identity in 104 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). TBparse score is FT 0.863." FT /db_xref="GOA:P95154" FT /db_xref="InterPro:IPR007341" FT /db_xref="UniProtKB/TrEMBL:P95154" FT /protein_id="CAB06126.1" FT /translation="MDITATTEFSAMNLDGKTGIGWLGYIVIGGIAGWLASKIVKGGGS FT GILMNVVIGVVGAFGAGLVLNALGVDVNHGGYWFTFFVALGGAVVLLWIVGMVRKT" FT misc_feature 30492..30515 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 30841..31881 FT /transl_table=11 FT /gene="adhA" FT /locus_tag="Rv1862" FT /product="Probable alcohol dehydrogenase adhA" FT /function="Catalyzes the reversible oxidation of ethanol to FT acetaldehyde with the concomitant reduction of NAD" FT /EC_number="1.1.1.1" FT /note="Rv1862, (MTCY359.11), len: 346 aa. Probable adhA, FT alcohol dehydrogenase (EC 1.1.1.1), similar to FT ADH2_BACST|P42327 alcohol dehydrogenase (339 aa), FASTA FT scores: opt: 630, E(): 2.4e-32 (34.4% identity in 320 aa FT overlap). Contains PS00059 Zinc-containing alcohol FT dehydrogenases signature. TBPARSE score is 0.899." FT /db_xref="GOA:P95153" FT /db_xref="InterPro:IPR014187" FT /db_xref="UniProtKB/TrEMBL:P95153" FT /protein_id="CAB06125.1" FT /translation="MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAV FT HACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVIEVGSAVGAAAGGEFDRGDRVGIAW FT LRHTCGVCKYCRRGSENLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSELAPL FT LCAGIIGYRSLLRTELPPGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLAL FT QLGAASAQDAADRPPVPLDAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNY FT QQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPEYPLGQADRALGDLSAGRIAG FT AAVLLI" FT misc_feature 31054..31098 FT /note="PS00059 Zinc-containing alcohol dehydrogenases FT signature" FT CDS complement(31888..32658) FT /transl_table=11 FT /locus_tag="Rv1863c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1863c, (MTCY359.10), len: 256 aa. Probable FT conserved integral membrane protein, similar to FT Rv0804|Z95618|MTCY7H7A.05 Hypothetical protein from FT Mycobacterium tuberculosis (209 aa), FASTA scores: opt: FT 199, E(): 1e-06, (33.2% identity in 220 aa overlap); and FT Rv0658c. TBPARSE score is 0.912." FT /db_xref="GOA:P95152" FT /db_xref="InterPro:IPR015837" FT /db_xref="UniProtKB/TrEMBL:P95152" FT /protein_id="CAB06124.1" FT /translation="MSDHLTACAAVHPGPLVSHLSVMHRFRIYVDIAVVVLVLVLTNLI FT AHFTTPWASIATVPAAAVGLVILVRSRGLGWAELGLSRQHWKSGLVYALAAVALVVAVI FT SVGVLLPITRPMFMNHHYATISGAVIASMVMIPLQTVIPEELAFRGVLHGALNRAWGFR FT GVAVAGSVLFGLWHIATSLGLTSSNVGFTRLFGGGIIGLVAGVMLAVLATGVAGFVFSW FT LRRRSGSLIAPIALHWSLNGMGALAAALVWHLST" FT CDS complement(32651..33406) FT /transl_table=11 FT /locus_tag="Rv1864c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1864c, (MTCY359.09), len: 251 aa. Conserved FT hypothetical protein. Similar to other hypothetical FT proteins e.g. AL031317|SC6G4.43 from Streptomyces FT coelicolor cosmid 6G (233 aa), FASTA scores: opt: 716, E(): FT 0, (54.4% identity in 215 aa overlap); also FT P43976|YIIM_HAEIN hypothetical protein hi0278 (221 aa), FT FASTA scores: opt: 223, E(): 3.8e-08, (29.5% identity in FT 173 aa overlap). TBPARSE score is 0.919" FT /db_xref="GOA:P95151" FT /db_xref="InterPro:IPR015808" FT /db_xref="UniProtKB/TrEMBL:P95151" FT /protein_id="CAB06123.1" FT /translation="MTVAPRRLAWTNARQSYPVRVAHVLSVNLARVRANPDPRAQSKLT FT GIDKVAASEAVMVRAPGSMHAGVGSGLVGDTVGNPKLHGGDDQAVYAYAREDLDAWETQ FT LHRTLHNGMFGENLTTSGVDVTYARIGERWRIGSDGLVLEVSAPRIPCRTFAAFLDLRY FT WIKTFTRAAKPGAYLRVIAPGTVRAGDTITVDYRPEHNVTVGLVFRARTSESELLPQLL FT AADALAAELKAYARERTPSPPPVDSADDV" FT CDS complement(33403..34263) FT /transl_table=11 FT /locus_tag="Rv1865c" FT /product="PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.-.-.-" FT /note="Rv1865c, (MTCY359.08), len: 286 aa. Probable FT short-chain dehydrogenase (EC 1.-.-.-), highly similar to FT C-terminus of NP_301650.1|NC_00267 putative oxidoreductase FT from Mycobacterium leprae (596 aa). Also similar to various FT dehydrogenases, generally belonging to short-chain family, FT e.g. AAG02168.1|AF212041_24|AF212041 3-oxoacyl-(acylcarrier FT protein) reductase from Zymomonas mobilis (251 aa); FT P50198|LINX_PSEPA 2,5-DICHLORO-2,5-CYCLOHEXADIENE-1,4-DIOL FT DEHYDROGENASE from Sphingomonas paucimobilis (250 aa); FT NP_105680.1|NC_002678 sorbitol dehydrogenase (also similar FT to acetoin reductase) from Mesorhizobium loti (256 aa); FT etc. And highly similar to C-terminus of FT ephD|Rv2214c|MTCY190.25c from Mycobacterium tuberculosis FT (592 aa); and many other oxidoreductases from Mycobacterium FT tuberculosis e.g. Y00P_MYCTU|Q10402 putative oxidoreductase FT (650 aa), FASTA scores: opt: 439, E(): 8.9e-20, (32.5% FT identity in 280 aa overlap). Contains PS00061 Short-chain FT alcohol dehydrogenase family signature. BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P95150" FT /db_xref="HSSP:1NFF" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95150" FT /protein_id="CAB06122.1" FT /translation="MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKVA FT IGDIDEAMAKESGADLDLDMYGKLDVTDPDSFSGFLDAVERQLGPIDVLVNNAGIMPVG FT RIVDEPDPVTRRILDINVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVATYC FT ASKHAVVAFTDSARLEYRSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIV FT GLIVHPKPRVRVTKAAGSMIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEAR FT ARGEE" FT misc_feature complement(33733..33819) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 34437..36773 FT /transl_table=11 FT /locus_tag="Rv1866" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID FT DEGRADATION." FT /note="Rv1866, (MTCY359.07c), len: 778 aa. Conserved FT hypothetical protein, N-terminal region similar to fatty FT acyl-CoA racemases e.g. Rv0855, Rv1143, and C-terminal FT region (from aa 370) similar to L-carnitine dehydratases, FT racemases, and Rv3272|MTCY71.12 Mycobacterium tuberculosis FT (394 aa), FASTA score: opt: 472, E(): 2.1e-21, (29.9% FT identity in 388 aa overlap). Also similar to FT P31572|CAIB_ECOLI L-CARNITINE DEHYDRATASE (EC 4.2.1.89) FT (405 aa), FASTA score: opt: 306, E(): 2.1e-11, (23.3% FT identity in 424 aa overlap). TBPARSE score is 0.921." FT /db_xref="GOA:P95149" FT /db_xref="InterPro:IPR006311" FT /db_xref="UniProtKB/TrEMBL:P95149" FT /protein_id="CAB06121.1" FT /translation="MVTRLLADLGADVLKVEPPGGSPGRHVRPTLAGTSIGFAMHNANK FT RSAVLNPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVALSITD FT FGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATAAVQAAWAVLVAYF FT NRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGIRSTGRWRGRPKNQDAYPIYPCR FT DGYVRFCVMAPRQWRGLRRWLGEPEDFQDPKYDVIGARLAAWPQISVLVAKLCAEKTMK FT ELVAAGQALGVPITAVLTPSRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRA FT GFRTPAPAAGQDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDL FT GAEVIKVESADHPDGLRQTRVGDAMSESFAWTHRNHLALGLDLRNSEGKAIFGRLVAES FT DAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNRGPWSTRMGYGPLVRAATGV FT TRVWTSDEAQPDNSRHPFYDATTIFPDHVVGRVGALLALAALIHRDRTGGGAHVHISQA FT EVVVNQLDTMFVAEAARATDVAEIHPDTSVHAVYPCAGDDEWCVISIRSDDEWRRATSV FT FGQPELANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMNRPS FT DILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAPLPGQDSVQICRK FT LLGMTADETERLINERVMFGPAVTA" FT CDS 37061..38545 FT /transl_table=11 FT /locus_tag="Rv1867" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID FT DEGRADATION." FT /note="Rv1867, (MTCY359.06c), len: 494 aa. Conserved FT hypothetical protein, some similarity to acetyl CoA FT synthase and to lipid carriers. FASTA best: E155295 acetyl FT CoA synthase (388 aa), opt: 213, E(): 4.5e-07, (23.2% FT identity in 423 aa overlap), TBPARSE score is 0.899." FT /db_xref="GOA:P95148" FT /db_xref="UniProtKB/TrEMBL:P95148" FT /protein_id="CAB06120.1" FT /translation="MPVDPRTPVLIGYGQVNHRGDIDAEKQSIEPVDLMAAAARKAADS FT TVLEAVDSIRVVHMLSAHYRNPGQLLGERIKARTFTTGYSGVGGNMPQSLVNRACLDIQ FT RGRAGVVLLAGAETWRTRTGLRAKGSKLEWTVQDESVPLPDMAGDDVPMAGAAELRINL FT DRPAYVYPIFEQALRIAYGESIENHRKRIGELWARFSAVAADNPHAWIRNPVTADEIWQ FT PGPQNRMVSWPYTKLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTP FT AVADRHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGLDTDDP FT ARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITANGGYLTKHSFGVYGT FT EPPSEFRWEDMQPAVDREPTGDGLVEWEGIGTVEAWTTPVNRDGQPEKAFLAVRTPDGS FT RSLAVITDPASVQATVREDIAGVKVAVAPDGTATLR" FT CDS 38644..40743 FT /transl_table=11 FT /locus_tag="Rv1868" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1868, (MTCY359.05c), len: 699 aa. Conserved FT hypothetical protein, similar to products of three FT consecutive ORFS in Mycobacterium leprae FT MLCB2052.18|Z98604|B2052 (257 aa), FASTA scores: opt: 314, FT E(): 9.9e-12, (35.2% identity in 213 aa overlap); FT MLCB2052.17, and MLCB2052.16. Also similar to M. FT tuberculosis hypothetical protein Rv2047c. TBPARSE score is FT 0.926." FT /db_xref="GOA:P95147" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95147" FT /protein_id="CAB06119.1" FT /translation="MQILVTDATGAVGRSVTRQLIAAGHTVSGIAQHPHDALDPRVDYV FT CASLRNPVLQELAGEADAVIHLAPVDTSAPGGVGITGLAHVANAAARAGARLLFVSQAA FT GRPELYRQAETLVSTGWAPSLVIRIAPPVGRQLDWMVCRTVATLLRSKVSARPIRVLHL FT DDLVRFLVLALNTDRNGVVDLATPDTTNVVTAWRLLRSVDPHLRTRRVRSWEQLIPEVD FT IAAVQEDWNFEFGWQATEAIVDTGRGLVGRRLHPAGATNGSGQLALPVEAPPRSVPSHG FT EPLGSAAPEGLEGEFDDRIDERFPVFSSASLAEALPGPLTPMTLDVQLSGLRAAGRAMG FT RVLALGGVVADEWERRAIAVFGHRPYIGVSANIVAAAQLPGWDAQAVARRALGEQPQVT FT ELLPFGRPQLAGGPLGSVAKVVVTARSLALLRHLRSDTHHYVAAADAEHLAAGQLASLP FT DAGLEVRIRLLRDRIHQGWILTVLWVIDTGVTAATLEHTRAGSAVSGGGMIMESGRIGA FT EIAPLAAVLRADPPLCALANDGNLASIRALSAPAAAAVDAVIARIGHRGLGEAELANLT FT FADDPALLLKTAAEIAARPAGPAHPATLIQRLAAGTRSARELAHDTTIRFTHELRMTLR FT ELGSRRVAADVIDVVDDVFYLTCDELITTPADARLRIKRRRAERERLQAQRPPDVIDHA FT WVPVE" FT CDS complement(40757..41992) FT /transl_table=11 FT /locus_tag="Rv1869c" FT /product="Probable reductase" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.-.-.-" FT /note="Rv1869c, (MTCY359.04), len: 411 aa. Probable FT reductase (1.-.-.-). Similar to several reductases e.g. FT CAC04223.1|AL391515 putative ferredoxin reductase from FT Streptomyces coelicolor (420 aa); THCD_RHOSO|P43494 FT rhodocoxin reductase (426 aa), FASTA scores: opt: 904, E(): FT 0, (40.8% identity in 370 aa overlap). Also similar to FT Mycobacterium tuberculosis proteins Rv0688 (406 aa) (39.9% FT identity in 391 aa overlap); and Rv0253 (nitrite reductase FT subunit). TBPARSE score is 0.918." FT /db_xref="GOA:P95146" FT /db_xref="HSSP:1M6I" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:P95146" FT /protein_id="CAB06118.1" FT /translation="MASSTTFVIVGGGLAGAKAVEALRRSDFGGRIILFGDEEHLPYDR FT PPLSKEFLAGKKSLSDFTIQTSDWYRDHDVDVRLGVRVSSLDRSAHTVELPDGAAVRYD FT KLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGSSLAVVGAGWIGLEVAA FT SARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQLEEITAADGKAT FT GLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDI FT AAAEHPLLGTRVRTEHWANALKQPAVAAAGMLGRPGEYAELPYLFTDQYDLGMEYVGHA FT PSCDRVVFRGNVAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSGNPVDVDRLV FT DPQWPLADLTTN" FT CDS complement(42092..42727) FT /transl_table=11 FT /locus_tag="Rv1870c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1870c, (MTCY359.03), len: 211 aa. Conserved FT hypothetical protein. Some similarity to SC6F7.17c FT hypothetical protein from Streptomyces coelicolor (216 aa). FT TBPARSE score is 0.939" FT /db_xref="UniProtKB/TrEMBL:P95145" FT /protein_id="CAB06117.1" FT /translation="MPPRIAGMRLLVIKPEPLARRLLKLAGTTYAAEAGIRIRDKPMPL FT FQLLVLCMLASKPIGAATAARAARELFCSGLRTPKAVLSAERQTMISAFGRAHYVRYDE FT SSATRLTAIAHRVRDEYSGDLRELAQRTRPDVSAAKRMLKTFNGIGDTGADIFLREVQD FT VWIWVRPYFDDRATAAAKQLGLPTDPKKLASVAPSSNALLAAALVRVA" FT CDS complement(42792..43181) FT /transl_table=11 FT /locus_tag="Rv1871c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1871c, (MTCY359.02), len: 129 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical proteins Q11057|Rv1261|MTCY50.21 (149 aa), FT FASTA score: opt: 125, E(): 0.019, (32.6% identity in 89 aa FT overlap); Rv0523c, and Rv1598c. TBPARSE score is 0.909" FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/TrEMBL:P95144" FT /protein_id="CAB06142.1" FT /translation="MNAAMNLKREFVHRVQRFVVNPIGRQLPMTMLETIGRKTGQPRRT FT AVGGRVVDNQFWMVSEHGEHSDYVYNIKANPAVRVRIGGRWRSGTAYLLPDDDPRQRLR FT GLPRLNSAGVRAMGTDLLTIRVDLD" FT CDS complement(43204..44448) FT /transl_table=11 FT /gene="lldD2" FT /locus_tag="Rv1872c" FT /product="POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) FT LLDD2" FT /function="INVOLVED IN RESPIRATION; CATALYZES CONVERSION OF FT LACTATE INTO PYRUVATE [CATALYTIC ACTIVITY: (S)-LACTATE + 2 FT FERRICYTOCHROME C = PYRUVATE + 2 FERROCYTOCHROME C]." FT /EC_number="1.1.2.3" FT /note="Rv1872c, (MTCY180.46, MTCY359.01), len: 414 aa FT (start uncertain). Possible lldD2, L-lactate dehydrogenase FT (cytochrome) (EC 1.1.2.3), similar to other lactate FT dehydrogenases and other oxidases e.g. LLDD_ECOLI|P33232 FT l-lactate dehydrogenase (cytochrome) from Escherichia coli FT strain K12 (396 aa), FASTA results: opt: 674, E(): 1.1e-37, FT (40.5% identity in 279 aa overlap); Q51135 LACTATE FT DEHYDROGENASE from Neisseria meningitidis (390 aa), FASTA FT results: opt: 309, E(): 4.1e-15, (42.5% identity in 113 aa FT overlap); etc. Also shows similarity with FT Rv0694|lldD1|MTCY210.11 POSSIBLE L-LACTATE DEHYDROGENASE FT (CYTOCHROME) from Mycobacterium tuberculosis (396 aa). FT Contains PS00557 FMN-dependent alpha-hydroxy acid FT dehydrogenases active site. BELONGS TO THE FMN-DEPENDENT FT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY. TBparse score is FT 0.905." FT /db_xref="GOA:P95143" FT /db_xref="HSSP:1AL8" FT /db_xref="InterPro:IPR017934" FT /db_xref="UniProtKB/TrEMBL:P95143" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06144.1" FT /translation="MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAK FT RRTPRAAFDYADGGAEDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPTVLPF FT GIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQLYMW FT RDRDRSMALVRRVAAAGFDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHP FT RWWFDLLTTEPLAFASLDRWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQT FT LDDARAVVDRGVDGIVLSNHGGRQLDRAPVPFHLLPHVARELGKHTEILVDTGIMSGAD FT IVAAIALGARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPR FT HVTQLRRLGPIGAPT" FT misc_feature complement(43534..43554) FT /note="PS00557 FMN-dependent alpha-hydroxy acid FT dehydrogenases active site" FT CDS 44471..44908 FT /transl_table=11 FT /locus_tag="Rv1873" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1873, (MTCY180.45c), len: 145 aa. Conserved FT hypothetical protein. Some similarity to AL591783 FT hypothetical protein from Sinorhizobium meliloti. TBparse FT score is 0.909." FT /db_xref="InterPro:IPR014937" FT /db_xref="PDB:2JEK" FT /db_xref="UniProtKB/TrEMBL:O07756" FT /protein_id="CAB10052.1" FT /translation="MKSASDPFDLKRFVYAQAPVYRSVVEELRAGRKRGHWMWFVFPQL FT RGLGSSPLAVRYGISSLEEAQAYLQHDLLGPRLHECTGLVNQVQGRSIEEIFGPPDDLK FT LCSSMTLFARATDANQDFVALLAKYYGGGEDRRTVALLAVT" FT CDS 44981..45667 FT /transl_table=11 FT /locus_tag="Rv1874" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1874, (MTCY180.44c), len: 228 aa. Hypothetical FT unknown protein, TBparse score is 0.928" FT /db_xref="UniProtKB/TrEMBL:O07755" FT /protein_id="CAB10067.1" FT /translation="MLMRPEPDDDWCARQRAQVADALLGLGVAGLSINVRDSTVRDSLM FT TLTTLYPPVAAVVSLWTQQCYGEQVAAALRLLAQECDELGAYLVTESVPLTFPSLVESG FT SRTPGLANIALLRRPDGLDQATWLTRWQRDHTQVAIEAQATFGYTQNWVVRALTPEAPG FT IAGIVEELFPVAATTDLKAFFGAADDNDLRNRISRMVASTSAFGANQNIDTVPTSRYVF FT RTPFKD" FT CDS 45678..46121 FT /transl_table=11 FT /locus_tag="Rv1875" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1875, (MTCY180.43c), len: 147 aa. Conserved FT hypothetical protein. Some similarity to Mycobacterium FT tuberculosis hypothetical proteins e.g. FT Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, FT E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c FT and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical FT protein from Streptomyces coelicolor (144 aa), FASTA FT scores: opt: 239, E(): 3.1 e-09, (38.7% identity in 137 aa FT overlap). TBparse score is 0.908" FT /db_xref="GOA:O07754" FT /db_xref="InterPro:IPR019920" FT /db_xref="UniProtKB/TrEMBL:O07754" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10051.1" FT /translation="MTTLNEAAALAAAERGLAVVSTVRADGTVQASLVNVGLLPHPVSG FT EPSLGFTTYGKVKLGNLRARPQLAVTFRNGWQWATVEGRAQLVGPDDPRPWLVDGERLR FT LLLREVFTAAGGTHDDWDEYDRVMAQEQRAVVLITPTRIYSNG" FT CDS 46637..47116 FT /transl_table=11 FT /gene="bfrA" FT /locus_tag="Rv1876" FT /standard_name="bfr" FT /product="PROBABLE BACTERIOFERRITIN BFRA" FT /function="INVOLVED IN IRON STORAGE (MAY PERFORM ANALOGOUS FT FUNCTIONS IN IRON DETOXIFICATION AND STORAGE AS THAT OF FT ANIMAL FERRITINS); FERRITIN IS AN INTRACELLULAR MOLECULE FT THAT STORES IRON IN A SOLUBLE, NONTOXIC, READILY AVAILABLE FT FORM. THE FUNCTIONAL MOLECULE, WHICH IS COMPOSED OF 24 FT CHAINS, IS ROUGHLY SPHERICAL AND CONTAINS A CENTRAL CAVITY FT IN WHICH THE POLYMERIC FERRIC IRON CORE IS DEPOSITED." FT /note="Rv1876, (MTCY180.42c), len: 159 aa. Probable bfrA FT (alternate gene name: bfr), bacterioferritin (see citation FT below), similar to BFR_MYCLE|P43315 bacterioferritin (bfr) FT from Mycobacterium leprae (159 aa), FASTA results: opt: FT 958, E(): 0, (90.6% identity in 159 aa overlap). Also FT similar to Rv3841|MTCY01A6.28c|bfrB POSSIBLE FT BACTERIOFERRITIN from Mycobacterium tuberculosis (181 aa). FT BELONGS TO THE BACTERIOFERRITIN FAMILY. TBparse score is FT 0.913." FT /db_xref="GOA:P63697" FT /db_xref="HSSP:1BCF" FT /db_xref="InterPro:IPR012347" FT /db_xref="UniProtKB/Swiss-Prot:P63697" FT /protein_id="CAB10050.1" FT /translation="MQGDPDVLRLLNEQLTSELTAINQYFLHSKMQDNWGFTELAAHTR FT AESFDEMRHAEEITDRILLLDGLPNYQRIGSLRIGQTLREQFEADLAIEYDVLNRLKPG FT IVMCREKQDTTSAVLLEKIVADEEEHIDYLETQLELMDKLGEELYSAQCVSRPPT" FT CDS 47201..49264 FT /transl_table=11 FT /locus_tag="Rv1877" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF DRUG FT ACROSS THE MEMBRANE." FT /note="Rv1877, (MTCY180.41c), len: 687 aa. Probable FT conserved integral membrane protein, part of major FT facilitator superfamily (MFS), similar to many antibiotic FT and drug efflux proteins. Similar to e.g. Q56175 TU22 FT DTDP-GLUCOSE DEHYDRTATASE from Streptomyces violaceoruber FT (557 aa), FASTA scores: opt: 895, E(): 0, (34.7% identity FT in 528 aa overlap). Also similar to Mycobacterium FT tuberculosis relatives protein, include Rv3728, Rv3239c, FT Rv2846c, etc. Contains PS00217 Sugar transport proteins FT signature 2 (PS00217). TBparse score is 0.916." FT /db_xref="GOA:O07753" FT /db_xref="InterPro:IPR001958" FT /db_xref="UniProtKB/TrEMBL:O07753" FT /protein_id="CAB10049.1" FT /translation="MAGPTAPTTAPTAIRAGGPLLSPVRRNIIFTALVFGVLVAATGQT FT IVVPALPTIVAELGSTVDQSWAVTSYLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVV FT GSVLCGLSQTMTMLAISRALQGVGAGAISVTAYALAAEVVPLRDRGRYQGVLGAVFGVN FT TVTGPLLGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDYLGILVIA FT VATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGRAAAAILPPRLFGSPV FT FAVCCVLSFVVGFAMLGALTFVPIYLGYVDGASATASGLRTLPMVIGLLIASTGTGVLV FT GRTGRYKIFPVAGMALMAVAFLLMSQMDEWTPPLLQSLYLVVLGAGIGLSMQVLVLIVQ FT NTSSFEDLGVATSGVTFFRVVGASFGTATFGALFVNFLDRRLGSALTSGAVPVPAVPSP FT AVLHQLPQSMAAPIVRAYAESLTQVFLCAVSVTVVGFILALLLREVPLTDIHDDADDLG FT DGFGVPRAESPEDVLEIAVRRMLPNGVRLRDIATQPGCGLGVAELWALLRIYQYQRLFE FT AVRLTDIGRHLHVPYQVFEPVFDRLVQTGYAARDGDILTLTPSGHRQVDSLAVLIRQWL FT LDHLAVAPGLKRQPDHQFEAALQHVTDAVLVQRDWYEDLGDLSESRQLAATT" FT misc_feature 47570..47647 FT /note="PS00217 Sugar transport proteins signature 2" FT CDS 49319..50671 FT /transl_table=11 FT /gene="glnA3" FT /locus_tag="Rv1878" FT /product="PROBABLE GLUTAMINE SYNTHETASE GLNA3 (GLUTAMINE FT SYNTHASE) (GS-I)" FT /function="INVOLVED IN GLUTAMINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY: ATP + L-GLUTAMATE + NH(3) = ADP + GLUTAMINE + FT ORTHOPHOSPHATE]." FT /EC_number="6.3.1.2" FT /note="Rv1878, (MTCY180.40c), len: 450 aa. Probable glnA3, FT glutamine synthetase class I (EC 6.3.1.2), similar to many FT e.g. GLNA_BACCE|P19064 from Bacillus cereus (443 aa), FASTA FT results: opt: 497, E(): 5.2e-23, (29.0% identity in 331 aa FT overlap); etc. Also similar to C-terminus of FT FLUG_EMENI|P38094 flug protein from emericella nidulans FT (865 aa), FASTA scores: opt: 227, E (): 6.4e-13, (29.9% FT identity in 394 aa overlap). Note that the downstream ORF FT MTCY180.39c is similar to the N-terminus. Also similar to FT three other potential glutamine synthases in M. FT tuberculosis: FT Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY42 FT 7. 03c; Rv2860c|MTV003.06c|glnA4 and Rv2220|glnA1. BELONGS FT TO THE GLUTAMINE SYNTHETASE FAMILY. TBparse score is FT 0.925." FT /db_xref="GOA:O07752" FT /db_xref="HSSP:1LGR" FT /db_xref="InterPro:IPR014746" FT /db_xref="UniProtKB/TrEMBL:O07752" FT /protein_id="CAB10048.1" FT /translation="MTATPLAAAAIAQLEAEGVDTVIGTVVNPAGLTQAKTVPIRRTNT FT FANPGLGASPVWHTFCIDQCSIAFTADISVVGDQRLRIDLSALRIIGDGLAWAPAGFFE FT QDGTPVPACSRGTLSRIEAALADAGIDAVIGHEVEFLLVDADGQRLPSTLWAQYGVAGV FT LEHEAFVRDVNAAATAAGIAIEQFHPEYGANQFEISLAPQPPVAAADQLVLTRLIIGRT FT ARRHGLRVSLSPAPFAGSIGSGAHQHFSLTMSEGMLFSGGTGAAGMTSAGEAAVAGVLR FT GLPDAQGILCGSIVSGLRMRPGNWAGIYACWGTENREAAVRFVKGGAGSAYGGNVEVKV FT VDPSANPYLASAAILGLALDGMKTKAVLPSETTVDPTQLSDVDRDRAGILRLAADQADA FT IAVLDSSKLLRCILGDPVVDAVVAVRQLEHERYGDLDPAQLADKFRMAWSV" FT CDS 50674..51810 FT /transl_table=11 FT /locus_tag="Rv1879" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1879, (MTCY180.39c), len: 378 aa. Conserved FT hypothetical protein, similar to SCC22.14c|AL096839 FT hypothetical protein from Streptomyces coelicolor (368 aa), FT FASTA results: opt: 772, E(): 0 (40.3% identity in 372 aa FT overlap); and to N-terminal half of FT nodulin/glutamate-ammonia ligase-like protein. Some FT similarity to N-terminus of AL132958|ATT4D2_11 Arabidopsis FT thaliana (845 aa), FASTA results: opt: 354, E(): 3.1e-16, FT (29.2% identity in 383 aa overlap); and to FT P38094|FLUG_EMENI Flug protein of Emericella nidulans (865 FT aa), FASTA results: opt: 306, E(): 6.2e-13, (26.5% identity FT in 415 aa overlap). Note that the upstream ORF FT Rv1878|MTCY18 0.40c is similar to the C-terminus. TBparse FT score is 0.933" FT /db_xref="GOA:O07751" FT /db_xref="InterPro:IPR006992" FT /db_xref="UniProtKB/TrEMBL:O07751" FT /protein_id="CAB10047.1" FT /translation="MADSAGSDLTRHTAEVPLIDQHVHGCWLTEGNRRRFENALNEANT FT EPLADFDSGFDSQLGFAVRNHCAPILGLPRHVDPQTYWDRRSQFSEAELARRFLQAAGV FT TDWLVETGIGYDVSGMASVAGLGELSGSHAHEVVRLEQVAEQAVQASGDYASAFNEILR FT RRAATAVATKSILAYRGGFDGDLTEPPAAQVAEAAKRWRDRGGVRLQDRVLLRFGLHQA FT LRLGKPLQFHVGFGDRDADLHKANPLYLLDFLRQSGNTPIVLLHCYPYEREAGYLAQAF FT NNVYLDGGLSVHYLGARSPAFIGRLLELAPFRKIVYSSDGFGPAELHFLGATLWRSGIQ FT RVLRGFVERDDWCETDALRVVDLIAHGTAARIYRLGDR" FT CDS complement(51838..53154) FT /transl_table=11 FT /gene="cyp140" FT /locus_tag="Rv1880c" FT /product="Probable cytochrome p450 140 CYP140" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv1880c, (MT1929, MTCY180.38), len: 438 aa. Probable FT cyp140, cytochrome p450 (EC 1.14.-.-). Similar to FT Q00441|CPXJ_SACER 6-deoxyerythronolide beta hydroxylase FT (404 aa), FASTA scores: opt: 775, E(): 0, (44.2% identity FT in 319 aa overlap); and other members of the cytochrome FT P450 family. Related to Mycobacterium tuberculosis proteins FT include: Rv0766c, Rv2266, Rv0778, etc. Contains cytochrome FT P450 cysteine heme-iron ligand signature (PS00086). BELONGS FT TO THE CYTOCHROME P450 FAMILY. TBparse score is 0.926." FT /db_xref="GOA:P63721" FT /db_xref="HSSP:1OXA" FT /db_xref="InterPro:IPR017972" FT /db_xref="UniProtKB/Swiss-Prot:P63721" FT /protein_id="CAB10066.1" FT /translation="MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPFY FT DEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQLH FT PLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIVDVV FT GRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRGFDCW FT LEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGN FT GIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVRIKRGEV FT VVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGEVGLRTFF FT DRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP" FT misc_feature complement(52006..52035) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(53204..53626) FT /transl_table=11 FT /gene="lppE" FT /locus_tag="Rv1881c" FT /product="POSSIBLE CONSERVED LIPOPROTEIN LPPE" FT /function="UNKNOWN" FT /note="Rv1881c, (MTCY180.37), len: 140 aa. Possible lppE, FT lipoprotein, showing some similarity to L12238|MSG18S19K_1 FT 19K antigen from Mycobacterium intracellulare (162 aa), FT FASTA scores: opt: 137, E(): 0.0069, (27.6% identity in 156 FT aa overlap). Contains signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site. TBparse score is 0.941." FT /db_xref="UniProtKB/TrEMBL:O07750" FT /protein_id="CAB10068.1" FT /translation="MCNRLVTVTGVAMVVAAGLSACGQAQTVPRKAARLTIDGVTHTTR FT PATCSQEHSYRTIDIRNHDSTVQAVVLLSGDRVIPQWVKIRNVDGFNGSFWHGGVGNAR FT ADRARNTYTVAGSAYGISSKKPNTVVSTDFNILAEC" FT CDS complement(53667..54500) FT /transl_table=11 FT /locus_tag="Rv1882c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.1.-.-" FT /note="Rv1882c, (MTCY180.36), len: 277 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), similar FT to various dehydrogenases/reductases, generally belonging FT to SDR family, e.g. NP_250789.1|NC_002516 probable FT short-chain dehydrogenase from Pseudomonas aeruginosa (251 FT aa); NP_421760.1|NC_002696 short chain dehydrogenase family FT protein from Caulobacter crescentus (270 aa); FT NP_107167.1|NC_002678 oxidoreductase (short chain FT dehydrogenase/reductase family) from Mesorhizobium loti FT (253 aa); P50197|LINC_PSEPA FT 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from FT Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 FT aa), FASTA scores: opt: 301, E(): 2.3e-12, (30.0% identity FT in 223 aa overlap); etc. Also similar to proteins from FT Mycobacterium tuberculosis e.g. Rv3057c, Rv1245, etc. FT Contains possible helix-turn-helix motif at aa 246-267 FT (+4.32 SD). Contains PS00061 Short-chain alcohol FT dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:O07749" FT /db_xref="HSSP:2HSD" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O07749" FT /protein_id="CAB10046.1" FT /translation="MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALRVQL FT GAERLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIGEGGWFEDVPYEAAVR FT VVDVNFKAVLTGAYAALPYLKKAPGSLMFSTSSSSGTYGMPRIAVYSATKHAVKGLTEA FT LSVEWQRHGVRVADVLPGLIDTAILTSTRQHSDEGPYTISAEQIRAAAPKKGMFRLMPS FT SSVAEAAWRAYQHPTRLHWYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK" FT misc_feature complement(54006..54092) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS complement(54528..54989) FT /transl_table=11 FT /locus_tag="Rv1883c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1883c, (MTCY180.35), len: 153 aa. Conserved FT hypothetical protein, some similarity to hypothetical FT proteins e.g. Rv2778c|AL008967|MTV002.43 from Mycobacterium FT tuberculosis (156 aa), FASTA score: opt: 212, E(): 3.1e-08, FT (34.4% identity in 151 aa overlap). Also similar to FT U75434|SAU75434_3 Nsh-OrfB from Streptomyces actuosus (173 FT aa), FASTA score: opt: 207, E(): 1.8e-07, (40.2% identity FT in 102 aa overlap). TBparse score is 0.923" FT /db_xref="InterPro:IPR005031" FT /db_xref="UniProtKB/TrEMBL:O07748" FT /protein_id="CAB10045.1" FT /translation="MCLDQVMEGSATVHMAAPPDKIWTLIADVRNTGRFSPETFEAEWL FT DGATGPALGARFRGHVRRNGIGPVYWTVCEPGREFGFAVLLGDRPVNNWHYRLTPTADG FT TEVTESFRLPPSVLTTVYYRVFGGWLRQRRNIRDMTKTLQRIKDLVEAG" FT CDS complement(55028..55558) FT /transl_table=11 FT /gene="rpfC" FT /locus_tag="Rv1884c" FT /product="PROBABLE RESUSCITATION-PROMOTING FACTOR RPFC" FT /function="THOUGHT TO PROMOTE THE RESUSCITATION AND GROWTH FT OF DORMANT, NONGROWING CELL. COULD ALSO STIMULATES THE FT GROWTH OF SEVERAL OTHER HIGH G+C GRAM+ ORGANISMS, e.g. FT Mycobacterium avium, Mycobacterium bovis (BCG), FT Mycobacterium kansasii, Mycobacterium smegmatis." FT /note="Rv1884c, (MTCY180.34), len: 176 aa. Probable rpfC, FT resuscitation promoting factor (see citation below), FT similar to Z96935|MLRPF_1 resusicitation-promoting factor FT from Micrococcus luteus (220 aa), FASTA score: opt: 287, FT E() : 3.3e-11, (40.0% identity in 120 aa overlap). Also FT similar to others from Mycobacterium tuberculosis: FT Rv2389c|MTCY253.32|RPFD PROBABLE RESUSCITATION-PROMOTING FT FACTOR (154 aa), FASTA score: opt: 382, E(): 7.1e-17, FT (55.4% identity in 101 aa overlap); Rv0867c|RPFA FT (N-terminal part), Rv2450c|RPFE, and Rv1009|RPFB FT (C-terminal part). TBparse score is 0.927." FT /db_xref="GOA:O07747" FT /db_xref="InterPro:IPR010618" FT /db_xref="UniProtKB/TrEMBL:O07747" FT /protein_id="CAB10065.1" FT /translation="MHPLPADHGRSRCNRHPISPLSLIGNASATSGDMSSMTRIAKPLI FT KSAMAAGLVTASMSLSTAVAHAGPSPNWDAVAQCESGGNWAANTGNGKYGGLQFKPATW FT AAFGGVGNPAAASREQQIAVANRVLAEQGLDAWPTCGAASGLPIALWSKPAQGIKQIIN FT EIIWAGIQASIPR" FT CDS complement(55570..56169) FT /transl_table=11 FT /locus_tag="Rv1885c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1885c, (MTCY180.33), len: 199 aa. Conserved FT hypothetical protein, some similarity to P42517|CHMU_ERWHE FT MONOFUNCTIONAL CHORISMATE MUTASE (181 aa), FASTA score: FT opt: 181, E(): 0.00017, (28.6% identity in 133 aa overlap). FT TBparse score is 0.926." FT /db_xref="GOA:O07746" FT /db_xref="InterPro:IPR008240" FT /db_xref="PDB:2AO2" FT /db_xref="UniProtKB/TrEMBL:O07746" FT /protein_id="CAB10064.1" FT /translation="MLTRPREIYLATAVSIGILLSLIAPLGPPLARADGTSQLAELVDA FT AAERLEVADPVAAFKWRAQLPIEDSGRVEQQLAKLGEDARSQHIDPDYVTRVFDDQIRA FT TEAIEYSRFSDWKLNPASAPPEPPDLSASRSAIDSLNNRMLSQIWSHWSLLSAPSCAAQ FT LDRAKRDIVRSRHLDSLYQRALTTATQSYCQALPPA" FT CDS complement(56187..57164) FT /transl_table=11 FT /gene="fbpB" FT /locus_tag="Rv1886c" FT /standard_name="mpt59; 85B" FT /product="SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 FT COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING FT PROTEIN B) (EXTRACELLULAR ALPHA-ANTIGEN)" FT /function="INVOLVED IN CELL WALL MYCOLOYLATION. PROTEINS OF FT THE ANTIGEN 85 COMPLEX ARE RESPONSIBLE FOR THE HIGH FT AFFINITY OF MYCOBACTERIA TO FIBRONECTIN. POSSESSES A FT MYCOLYLTRANSFERASE ACTIVITY REQUIRED FOR THE BIOGENESIS OF FT TREHALOSE DIMYCOLATE (CORD FACTOR), A DOMINANT STRUCTURE FT NECESSARY FOR MAINTAINING CELL WALL INTEGRITY." FT /EC_number="2.3.1.-" FT /note="Rv1886c, (MT1934, MTCY180.32), len: 325 aa. fbpB FT (alternate gene names: mpt59, 85B), precursor of the 85-B FT antigen (fibronectin-binding protein B) (mycolyl FT transferase 85B) (EC 2.3.1.-) (see citations below), highly FT similar to other Mycobacterial antigen precursors e.g. FT P12942|A85B_MYCBO ANTIGEN 85-B PRECURSOR from Mycobacterium FT bovis (323 aa); P21160|A85B_MYCKA ANTIGEN 85-B PRECURSOR FT from Mycobacterium kansasii (325 aa); etc. Also highly FT similar to Mycobacterium tuberculosis antigen precursors: FT Rv3804c|fbpA (338 aa), Rv0129c|fbpC2 (340 aa), and FT Rv3803c|fbpC1 (299 aa). TBparse score is 0.912." FT /db_xref="GOA:P0C5B9" FT /db_xref="InterPro:IPR000801" FT /db_xref="PDB:1F0N" FT /db_xref="UniProtKB/Swiss-Prot:P0C5B9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10044.1" FT /translation="MTDVSRKIRAWGRRLMIGTAAAVVLPGLVGLAGGAATAGAFSRPG FT LPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQS FT GLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAI FT GLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGP FT SSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQ FT DAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG" FT CDS 57555..58697 FT /transl_table=11 FT /locus_tag="Rv1887" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1887, (MTCY180.31), len: 380 aa. Hypothetical FT unknown protein; contains eukaryotic thiol (cysteine) FT proteases histidine active site at N-terminus (PS00639) and FT Pro-rich region near C-terminus. TBparse score is 0.935." FT /db_xref="InterPro:IPR000169" FT /db_xref="UniProtKB/TrEMBL:O07745" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10063.1" FT /translation="MDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQAI FT HTAEQLAAEVLLAHEVAAAGDHRLRVIGVTWNAEASAQAALLVESLTGAGFDNVVPVRR FT LRAIETLAQAIAPVIGYEQIAVCVLEHESATVVMVDTHDGKTQIAVKHVCRGLSGLTSW FT LTGMFGRDAWRPAGVVVVGSDSEVSEFSWQLERVLPVPVFAQTMAQVTVARGAALAAAQ FT STEFTDAQLVADSVSQPTVAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLAPHNDT FT GTAKHGAHKPTPRIAKAVAPAVPPPPTVTPPVPARAPRPAAQHEPPARVTSGEALTEPN FT PPEEQPNASAPQQDRNDSQPITRVLEHIPGAYGDSAPPAE" FT misc_feature 57723..57755 FT /note="PS00639 Eukaryotic thiol (cysteine) proteases FT histidine active site" FT CDS complement(58816..59376) FT /transl_table=11 FT /locus_tag="Rv1888c" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1888c, (MTCY180.30), len: 186 aa. Possible FT transmembrane protein. TBparse score is 0.926." FT /db_xref="GOA:O07744" FT /db_xref="UniProtKB/TrEMBL:O07744" FT /protein_id="CAB10043.1" FT /translation="MQPDAYPVRVRGDLDPALSRWQWLVKWFLAIPHYIVLFFLHVAAV FT VVTVIAFFAILFTGRYPRTLFDFNVGVMRWRWRVAFYALSALGTDRYPPFSLQTKAEYP FT ADLEVDYPERLSRGLVLIKWWLLAIPHYLILAVFLSSGWRVFLIDPHDRVGIMWPSLLV FT ILLLVAVVALLFTGRYPIGLYNL" FT CDS complement(59741..59914) FT /transl_table=11 FT /locus_tag="Rv1888A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1888A, len: 57 aa. Conserved hypothetical protein. FT Possibly continuation of Rv1889c, part of large family of FT Mycobacterium tuberculosis proteins with conserved FT N-terminal domain of ~ 120 aa. Includes: C-terminus of FT Rv0726c|P95074 CONSERVED HYPOTHETICAL PROTEIN (367 aa), FT FASTA scores: opt: 295, E(): 3.1e-15, (73.684% identity in FT 57 aa overlap); C-terminus of Rv3399|Q50726|MTCY78.29c FT CONSERVED HYPOTHETICAL PROTEIN (348 aa), FASTA scores: opt: FT 504, E(): 7.3e-29, (64.2% identity in 120 aa overlap); FT C-terminus of Rv0731c; etc." FT /db_xref="UniProtKB/TrEMBL:Q79FJ0" FT /protein_id="CAE55439.1" FT /translation="MVPVDLRRDWPTPLRQAGFDPNQPSAWLAEGLLAFLPPDAQDRLL FT DNITALSAPGSR" FT CDS complement(59958..60314) FT /transl_table=11 FT /locus_tag="Rv1889c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1889c, (MTCY180.29), len: 118 aa. Conserved FT hypothetical protein. Part of large family of Mycobacterium FT tuberculosis proteins with conserved N-terminal domain of ~ FT 120 aa. Includes: Rv3399|Q50726|MTCY78.29C CONSERVED FT HYPOTHETICAL PROTEIN (348 aa), FASTA results: opt: 504, FT E(): 7.3e-29, (64.2% identity in 120 aa overlap); FT Rv0726c|P95074; Rv0731c; etc. Rv1888A possibly continuation FT of this CDS. TBparse score is 0.901." FT /db_xref="GOA:O07743" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/TrEMBL:O07743" FT /protein_id="CAB10042.1" FT /translation="MPRTNNDAWDLATSVGATATMVAAARAVATRADNPLIDDPFAEPL FT VRAVGIDFFTRWAAGNIKATDVDDPDGTWGLQRLADLLAARTRYFDAFFRDATSAGIRQ FT AVILASGLDARAYR" FT CDS complement(60373..60984) FT /transl_table=11 FT /locus_tag="Rv1890c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1890c, (MTCY180.28), len: 203 aa. Hypothetical FT unknown protein. TBparse score is 0.933" FT /db_xref="InterPro:IPR007372" FT /db_xref="UniProtKB/TrEMBL:O07742" FT /protein_id="CAB10062.1" FT /translation="MAHKTRREGRAGRSSEYSRGVSDAVWTLDASDGELVLRTGVVGRA FT ARLGHRLTIAMTRWQALVNWSGTDPVAGELVAEVDSFEVMRGEGGVKGLSEPEKALVRA FT NALKTLNASRFPHIRFTTEAIAQTGNGYRLTGKLHIRGKSREHVIDLHTEDLGAAWRIS FT ADTTVRQSNYGVKPYSLLMGSIRVADEVSVAFTAVRAKDD" FT CDS 61038..61445 FT /transl_table=11 FT /locus_tag="Rv1891" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1891, (MTCY180.27c), len: 135 aa. Conserved FT hypothetical protein. Equivalent to MLCB561.09|AL049571 FT hypothetical protein from Mycobacterium leprae (134 aa), FT FASTA scores: opt: 800, E(): 0, (79.7% identity in 133 aa FT overlap). TBparse score is 0.932." FT /db_xref="UniProtKB/TrEMBL:O07741" FT /protein_id="CAB10041.1" FT /translation="MIRELVTTAAITGAAIGGAPVAGADPQRYDGDVPGMNYDASLGAP FT CSSWERFIFGRGPSGQAEACHFPPPNQFPPAETGYWVISYPLYGVQQVGAPCPKPQAAA FT QSPDGLPMLCLGARGWQPGWFTGAGFFPPEP" FT CDS 61462..61773 FT /transl_table=11 FT /locus_tag="Rv1892" FT /product="PROBABLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1892, (MTCY180.26c), len: 103 aa. Probable FT membrane protein. TBparse score is 0.922." FT /db_xref="UniProtKB/TrEMBL:O07740" FT /protein_id="CAB10040.1" FT /translation="MIMCEGRPTESPIPRWLRFVLTSDRAGSAWYIGAGFFFAPVLAVL FT SPWPTITAVLWWIIGLAGLWLGLLGIAMAVGLARVLRSGAEIPEAYWRTLVDYRSANE" FT CDS 61783..62001 FT /transl_table=11 FT /locus_tag="Rv1893" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1893, (MTCY180.25c), len: 72 aa. Conserved FT hypothetical protein. Equivalent to MLCB561.11|AL049571 FT hypothetical protein from Mycobacterium leprae (74 aa), FT FASTA scores: opt: 317, E(): 4.6e-15, (69.4% identity in 72 FT aa overlap). TBparse score is 0.857." FT /db_xref="UniProtKB/TrEMBL:O07739" FT /protein_id="CAB10039.1" FT /translation="MSFNPKDAVDAVRDIAANAVEKASDIVENAGHIIRGDIAGGASGI FT VKDSIDIATHAVDRTKEVFTGKTDDEG" FT CDS complement(62036..63166) FT /transl_table=11 FT /locus_tag="Rv1894c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1894c, (MTCY180.24), len: 376 aa. Conserved FT hypothetical protein, weak similarity to some FT oxidoreductases e.g. Q01284 2-NITROPROPANE DIOXYGENASE FT PRECURSOR (378 aa), FASTA results: opt: 204, E(): 5.8e-06, FT (34.3% identity in 140 aa overlap). Similar to hypothetical FT Mycobacterium tuberculosis proteins e.g. FT Rv3553|MTCY03C7.02c (355 aa), FASTA results: opt: 296, E(): FT 1.6e-10, (32.9% identity in 167 aa overlap); Rv1533 (375 FT aa) (48.1% identity in 376 aa overlap); Rv0021c, Rv2781c. FT TBparse score is 0.902." FT /db_xref="GOA:O07738" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:O07738" FT /protein_id="CAB10038.1" FT /translation="MHTAICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFTPE FT QLEIELNWIDEHIGDHPYGVDIVIPNKYEGMDSQLSADELAKTLRSMVPQEHLDFARKI FT LADHGVPVEDADEDSLQLLGWTEATATPQVDAALKHPKMTMVANALGTPPADMIKHIHD FT SGRKVAALCGSPSQARKHADAGVDIIIAQGGEAGGHCGEVGSIVLWPQVVKEVAPVPVL FT AAGGIGSGQQIAAALALGTQGAWTGSQWLMVEEAANTAVQQAAYVKATSRDTVRSRSFT FT GKPARMLRNDWTEAWEQPESPKPLGMPLQYMVSGMAVKATHKYPNETVDVAFNPVGQVV FT GQFTKVEKTATVIERWVQEYLEATARLDALNAAASV" FT CDS 63818..64972 FT /transl_table=11 FT /locus_tag="Rv1895" FT /product="POSSIBLE DEHYDROGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.1.-.-" FT /note="Rv1895, (MTCY180.23c), len: 384 aa. Possible FT dehydrogenase (EC 1.1.-.-), similar to various sorbitol and FT alcohol dehydrogenases, and to putative FT glutathione-dependent aldehyde dehydrogenase e.g FT DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14) from FT Streptomyces coelicolor (352 aa), FASTA results: opt: 506, FT E(): 7.2e-24, (30.6% identity in 350 aa overlap); and FT AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE FT from Streptomyces coelicolor (356 aa), FASTA results: opt: FT 634, E(): 2.9e-30, (34.7% identity in 357 aa overlap). Also FT similar to other Mycobacterium tuberculosis dehydrogenases. FT Note that there is a substantial (134 bp) overlap at the FT C-terminus with the C-terminus of the downstream ORF, FT although both appear to be true coding regions. TBparse FT score is 0.922." FT /db_xref="GOA:O07737" FT /db_xref="HSSP:1F8F" FT /db_xref="InterPro:IPR013154" FT /db_xref="UniProtKB/TrEMBL:O07737" FT /protein_id="CAB10037.1" FT /translation="MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFY FT EGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGCETHDPVMCF FT SGPMIFGAGVLGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQRADI FT SFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPAAETI FT LAATRGRGADSVIDAVGTDASMSDALNAVRPGGTVSVVGVHDLQPFPVPALTCLLRSIT FT LRMTMAPVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELRFCLR FT PDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN" FT CDS complement(64832..65743) FT /transl_table=11 FT /locus_tag="Rv1896c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1896c, (MTCY180.22), len: 303 aa. Conserved FT hypothetical protein. Similar to several (14) hypothetical FT Mycobacterium tuberculosis proteins e.g. Rv0145|MTCI5.19 FT (317 aa), FASTA results: opt: 720, E(): 0, (41.6% identity FT in 308 aa overlap); Q10552|YZ21_MYCTU (325 aa), opt: 689, FT E(): 0, (40.5% identity in 304 aa overlap); Rv0726c, FT Rv0731c, Rv3399, etc. and to related proteins in other FT actinomycetes. Note that there is a substantial (134 bp) FT overlap at the C-terminus with the C-terminus of the FT downstream ORF, although both appear to be true coding FT regions. TBparse score is 0.946" FT /db_xref="GOA:O07736" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/Swiss-Prot:O07736" FT /protein_id="CAB10036.1" FT /translation="MTTPEYGSLRSDDDHWDIVSNVGYTALLVAGWRALHTTGPKPLVQ FT DEYAKHFITASADPYLEGLLANPRTSEDGTAFPRLYGVQTRFFDDFFNCADEAGIRQAV FT IVAAGLDCRAYRLDWQPGTTVFEIDVPKVLEFKARVLSERGAVPKAHRVAVPADLRTDW FT PTPLTAAGFDPQRPSAWSVEGLLPYLTGDAQYALFARIDELCAPGSRVALGALGSRLDH FT EQLAALETAHPGVNMSGDVNFSALTYDDKTDPVEWLVEHGWAVDPVRSTLELQVGYGLT FT PPDVDVKIDSFMRSQYITAVRA" FT CDS complement(65748..66179) FT /transl_table=11 FT /locus_tag="Rv1897c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1897c, (MTCY180.21), len: 143 aa. Conserved FT hypothetical protein. Some similarity to D63706|Q54235 ORF2 FT from Streptomyces griseus (149 aa), FASTA results: opt: FT 509, E(): 1.2e-28, (57.3% identity in 150 aa overlap); and FT Q45303 ORF1 PROTEIN from Corynebacterium glutamicum (144 FT aa), FASTA results: opt: 460, E(): 5.5e-23, (49.7% identity FT in 143 aa overlap)." FT /db_xref="GOA:P63995" FT /db_xref="HSSP:1JKE" FT /db_xref="InterPro:IPR003732" FT /db_xref="UniProtKB/Swiss-Prot:P63995" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10061.1" FT /translation="MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKA FT RRLAEKLWNLRVLADEKSASDMHAPILVISQFTLYADTAKGRRPSWNAAAPGAVAQPLI FT AAFAAALRQLGAHVEAGVFGAHMQVELVNDGPVTVMLEG" FT CDS 66237..66545 FT /transl_table=11 FT /locus_tag="Rv1898" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1898, (MTCY180.20c), len: 102 aa. Conserved FT hypothetical protein, some similarity to other hypothetical FT proteins e.g. Q58452 from METHANOCOCCUS JANNASCH II (100 FT aa), FASTA results: opt: 152, E(): 9.1e-05, (31.5% identity FT in 92 aa overlap); and AE000771|AE000771_2 from Aquifex FT aeolicus (157 aa), FASTA results: opt: 246, E(): 3.2e-11, FT (39.0% identity in 100 aa overlap). TBparse score is FT 0.874." FT /db_xref="InterPro:IPR002767" FT /db_xref="UniProtKB/Swiss-Prot:P67119" FT /protein_id="CAB10060.1" FT /translation="MSVLVAFSVTPLGVGEGVGEIVTEAIRVVRDSGLPNQTDAMFTVI FT EGDTWAEVMAVVQRAVEAVAARAPRVSAVIKVDWRPGVTDAMTQKVATVERYLLRPE" FT CDS complement(66511..67542) FT /transl_table=11 FT /gene="lppD" FT /locus_tag="Rv1899c" FT /product="POSSIBLE LIPOPROTEIN LPPD" FT /function="UNKNOWN" FT /note="Rv1899c, (MTCY180.19), len: 343 aa. Possible FT lipoprotein; contains appropriately localized lipoprotein FT lipid attachment site (PS00013). Some similarity to FT C-terminal part of AE000717|AE000717_4 hypothetical protein FT from Aquifex aeolicus section 49 (165 aa), FASTA results: FT opt: 372, E(): 2.3e-14, (43.5% identity in 147 aa overlap); FT and Q44020 4-hydroxybutyrate dehydrogenase (173 aa), FASTA FT results: opt: 272, E(): 4.7e-09, (35.8% identity in 165 aa FT overlap)." FT /db_xref="HSSP:1HJZ" FT /db_xref="InterPro:IPR002589" FT /db_xref="UniProtKB/Swiss-Prot:O07733" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10035.1" FT /translation="MSRAAGLPRLSWFAGLTWFAGGSTGAGCAAHPALAGLTAGARCPA FT YAAISASTARPAATAGTTPATGASGSARPTDAAGMADLARPGVVATHAVRTLGTTGSRA FT IGLCPCQPLDCPRSPQATLNLGSMGRSLDGPQWRRARVRLCGRWWRRSNTTRGASPRPP FT STCRGDNVSMIELEVHQADVTKLELDAITNAANTRLRHAGGVAAAIARAGGPELQREST FT EKAPIGLGEAVETTAGDMPARYVIHAATMELGGPTSGEIITAATAATLRKADELGCRSL FT ALVAFGTGVGGFPLDDAARLMVGAVRRHRPGSLQRVVFAVHGDAAERAFSAAIQAGEDT FT ARR" FT misc_feature complement(67459..67491) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(67542..68930) FT /transl_table=11 FT /gene="lipJ" FT /locus_tag="Rv1900c" FT /product="PROBABLE LIGNIN PEROXIDASE LIPJ" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /note="Rv1900c, (MTCY180.18), len: 462 aa. Probable lipJ, FT lignin peroxidase, with some similarity to esterases, FT hydrolases and hypothetical Mycobacterium tuberculosis FT proteins e.g. Q43936 BETA-KETOADIPATE ENOL-LACTONE FT HYDROLASE from Acinetobacter calcoaceticus (267 aa), FASTA FT results: opt: 217, E(): 1.7e-07, (29.2% identity in 260 aa FT overlap). Also similar to other Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv2212|Q10400|YM12_MYCTU (378 FT aa), FASTA results: opt: 216, E(): 6.7e-07, (27.7% identity FT in 285 aa overlap)." FT /db_xref="GOA:O07732" FT /db_xref="InterPro:IPR001054" FT /db_xref="PDB:1YBT" FT /db_xref="UniProtKB/TrEMBL:O07732" FT /protein_id="CAB10059.1" FT /translation="MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSI FT DDEPSLYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAVGCEQ FT ATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARPLWAPDYPVGAQVRRADPFLTVAL FT EPDAVERGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVRDVLG FT HIEAPTLILHRVGSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEF FT ITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGRE FT VNTAGDGFVATFTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHGTDVAGV FT AVHIGARVCALAGPSEVLVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDA FT TRTR" FT CDS 68959..70251 FT /transl_table=11 FT /gene="cinA" FT /locus_tag="Rv1901" FT /product="PROBABLE CINA-LIKE PROTEIN CINA" FT /function="UNKNOWN" FT /note="Rv1901, (MTCY180.17c), len: 430 aa. Probable FT cinA-like protein, strong similarity to competence damage FT proteins CinA of Bacillus subtilis and S. pneumoniae. FASTA FT results: Q55760 HYPOTHETICAL 44.7 kDa PROTEIN (416 aa) opt: FT 755, E(): 0, (36.0% identity in 433 aa overlap). TBparse FT score is 0.910." FT /db_xref="GOA:P63775" FT /db_xref="InterPro:IPR001453" FT /db_xref="UniProtKB/Swiss-Prot:P63775" FT /protein_id="CAB10034.1" FT /translation="MAVSARAGIVITGTEVLTGRVQDRNGPWIADRLLELGVELAHITI FT CGDRPADIEAQLRFMAEQGVDLIVTSGGLGPTADDMTVEVVARYCGRELVLDDELENRI FT ANILKKLMGRNPAIEPANFDSIRAANRKQAMIPAGSQVIDPVGTAPGLVVPGRPAVMVL FT PGPPRELQPIWSKAIQTAPVQDAIAGRTTYRQETIRIFGLPESSLADTLRDAEAAIPGF FT DLVEITTCLRRGEIEMVTRFEPNAAQVYTQLARLLRDRHGHQVYSEDGASVDELVAKLL FT TGRRIATAESCTAGLLAARLTDRPGSSKYVAGAVVAYSNEAKAQLLGVDPALIEAHGAV FT SEPVAQAMAAGALQGFGADTATAITGIAGPSGGTPEKPVGTVCFTVLLDDGRTTTRTVR FT LPGNRSDIRERSTTVAMHLLRRTLSGIPGSP" FT CDS complement(70303..71571) FT /transl_table=11 FT /gene="nanT" FT /locus_tag="Rv1902c" FT /product="PROBABLE SIALIC ACID-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN NANT" FT /function="INVOLVED IN TRANSPORT OF SIALIC ACID ACROSS THE FT MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1902c, (MTCY180.16), len: 422 aa. Probable nanT, FT sialic acid-transport integral membrane protein, possibly FT member of major facilitator superfamily (MFS), similar to FT others e.g. Q48076 SIALIC ACID TRANSPORTER (407 aa), FASTA FT results: opt: 443, E(): 5.4e-22, (26.7% identity in 389 aa FT overlap); etc. Some similarity to MTCI364.12|O05301 FT conserved hypothetical protein from Mycobacterium FT tuberculosis (425 aa), FASTA results: opt: 251, E(): FT 1.1e-09, (23.5% identity in 417 aa overlap). Contains sugar FT transport proteins signature 2 (PS00217). TBparse score is FT 0.920." FT /db_xref="GOA:O07730" FT /db_xref="InterPro:IPR004742" FT /db_xref="UniProtKB/TrEMBL:O07730" FT /protein_id="CAB10058.1" FT /translation="MAAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHT FT KTDVAFLTTATLAMRPVGALLFGLWADRVGRRVPLMVDVSFYSVIGFLCAFAPNFTVLV FT ILRLLYGIGMGGEWGLGAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVMNWL FT GLSWRWLFGLSIIPALISLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFV FT YLVLLMTAFNWMSHGTQDVYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGT FT LSQRFSRRYTIVFCAALGLPIVPLFAYSRTAAMLCLGSFLMQVFVQGAWGVIPAHLTEM FT SPDAIRGVYPGVTYQLGNLLAAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIG FT KDATGIRFGTTETAFLVRHRNRH" FT misc_feature complement(71170..71247) FT /note="PS00217 Sugar transport proteins signature 2" FT CDS 71661..72065 FT /transl_table=11 FT /locus_tag="Rv1903" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1903, (MTCY180.15c), len: 134 aa. Probable FT conserved membrane protein, similar to Q53868|YPT3_STRCO FT hypothetical 15.9 kDa protein from Streptomyces coelicolor FT (148 aa) opt: 323, E(): 1.3e-16, (42.9% identity in 126 aa FT overlap); and equivalent to AJ000521|MLCOSL672_3 from FT Mycobacterium leprae (139 aa), FASTA results: opt: 680, FT E(): 0, (80.6% identity in 129 aa overlap). TBparse score FT is 0.915." FT /db_xref="InterPro:IPR007165" FT /db_xref="UniProtKB/TrEMBL:O07729" FT /protein_id="CAB10033.1" FT /translation="MVPFLMRAAVTGFALWVVTLFVPGMRFAGGDTTLQRVAIIFVVAV FT IFGLVNAFIKPIVQILSIPLYILTLGLFHVVVNASMLWLTAWITEHTTHWGLQIDHFWW FT TAIWAAILLSIVSWILSLLARDFRRVTRAH" FT CDS 72251..72682 FT /transl_table=11 FT /locus_tag="Rv1904" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1904, (MTCY180.14c), len: 143 aa. Conserved FT hypothetical protein, some similarity to other hypothetical FT Mycobacterium tuberculosis proteins e.g. FT Rv2638|MTCY441.08|P71937 (148 aa), FASTA results: opt: 456, FT E( ): 2.7e-23, (52.8% identity in 125 aa overlap); FT Rv1365|Q11035 (128 aa), FASTA results: opt: 393, E(): FT 1.4e-19, (48.8% identity in 123 aa overlap); and Rv3687c. FT Also weak similarity to Q9WVX8|RSBV_STRCO ANTI-SIGMA B FT FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa)." FT /db_xref="GOA:O07728" FT /db_xref="InterPro:IPR003658" FT /db_xref="UniProtKB/TrEMBL:O07728" FT /protein_id="CAB10032.1" FT /translation="MRTVAIGPGAGPSSTRPSSQPSDLHSGLRAVTECTGSAVVVHVGG FT DIDASNEVAWQRLVSKSAAIAIAPGPFVIDIRDLDFMGSCAYAVLAQESVRCRRRGVNM FT RLVSNQPIVARTIAACGLRRLIPLYATVETALAPPPSAH" FT CDS complement(72730..73692) FT /transl_table=11 FT /gene="aao" FT /locus_tag="Rv1905c" FT /product="PROBABLE D-AMINO ACID OXIDASE AAO" FT /function="Wide specificity for D-amino acids. Also acts on FT glycine [CATALYTIC ACTIVITY: A D-AMINO ACID + H2O + O2 = A FT 2-OXO ACID + NH3 + H2O2]" FT /EC_number="1.4.3.3" FT /note="Rv1905c, (MTCY180.13), len: 320 aa. Probable aao, FT D-amino acid oxidase (EC 1.4.3.3), similar to many. FT Equivalent to AJ000521|MLCOSL672.02|O33145 Mycobacterium FT leprae (320 aa), FASTA results: opt: 1541, E(): 0, (71.7% FT identity in 315 aa overlap); also similar to FT OXDD_BOVIN|P31228 d-aspartate oxidase (EC 1.4.3.1) from bos FT taurus (338 aa), FASTA results: opt: 461, E(): 1.1e-21, FT (31.8% identity in 321 aa overlap). TBparse score is 0.932" FT /db_xref="GOA:O07727" FT /db_xref="HSSP:1AN9" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O07727" FT /protein_id="CAB10057.1" FT /translation="MAIGEQQVIVIGAGVSGLTSAICLAEAGWPVRVWAAALPQQTTSA FT VAGAVWGPRPKEPVAKVRGWIEQSLHVFRDLAKDPATGVRMTPALSVGDRIETGAMPPG FT LELIPDVRPADPADVPGGFRAGFHATLPMIDMPQYLDCLTQRLAATGCEIETRPLRSLA FT EAAEAAPIVINCAGLGARELAGDATVWPRFGQHVVLTNPGLEQLFIERTGGSEWICYFA FT HPQRVVCGGISIPGRWDPTPEPEITERILQRCRRIQPRLAEAAVIETITGLRPDRPSVR FT VEAEPIGRALCIHNYGHGGDGVTLSWGCAREVVNLVGGG" FT CDS complement(73722..74192) FT /transl_table=11 FT /locus_tag="Rv1906c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1906c, (MTCY180.12), len: 156 aa. Conserved FT hypothetical protein, possibly exported protein, equivalent FT to Mycobacterium leprae AJ000521|MLCOSL672.01 (153 aa), FT FASTA scores: opt: 637, E(): 2.6e-28, (63.2% identity in FT 155 aa overlap). Also similar to M. tuberculosis FT hypothetical exported protein, Rv1352." FT /db_xref="UniProtKB/TrEMBL:O07726" FT /protein_id="CAB10031.1" FT /translation="MRLKPAPSPAAAFAVAGLILAGWAGSVGLAGADPEPAPTPKTAID FT SDGTYAVGIDIAPGTYSSAGPVGDGTCYWKRMGNPDGALIDNALSKKPQVVTIEPTDKA FT FKTHGCQPWQNTGSEGAAPAGVPGPEAGAQLQNQLGILNGLLGPTGGRVPQP" FT CDS complement(74532..75179) FT /transl_table=11 FT /locus_tag="Rv1907c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1907c, (MTCY180.11), len: 215 aa. Hypothetical FT unknown protein. Similar to Q50763 Ethyl methane sulphonate FT resistance protein from Mycobacterium tuberculosis (168 FT aa), FASTA scores: opt: 638, E(): 0, (69.7% identity in 152 FT aa overlap). Downstream of a cloned katG gene FT (EMBL:MTKATG). Differences are due to frameshift errors in FT the EMBL sequence and the use of an earlier start codon. FT TBparse score is 0.958." FT /db_xref="UniProtKB/TrEMBL:O07725" FT /protein_id="CAB10069.1" FT /translation="MIGPARRSTTTRRSTPRADRLAGCWCLPGAICQTPRAWWSQARRD FT GDDETGMRRKGAEMCWMCDHPEATAEEYLDEVYGIMLMHGWAVQHVECERRPFAYTVGL FT TRRGLPELVVTGLSPRRGQRLLNIAARRALVGDLLTPGMQTTLPAGPLVETVQVTHPDA FT HLYCAIAIFGDKVTALQLVWADRRGRWPWAADFDEGRGTQPVLGMRATRRSA" FT CDS complement(75186..77408) FT /transl_table=11 FT /gene="katG" FT /locus_tag="Rv1908c" FT /product="CATALASE-PEROXIDASE-PEROXYNITRITASE T KATG" FT /function="MULTIFUNCTIONAL ENZYME, EXHIBITING BOTH A FT CATALASE, A BROAD-SPECTRUM PEROXIDASE, AND A FT PEROXYNITRITASE ACTIVITIES. MAY PLAY A ROLE IN THE FT INTRACELLULAR SURVIVAL OF MYCOBACTERIA WITHIN MACROPHAGES; FT PROTECTION AGAINST REACTIVE OXYGEN AND NITROGEN FT INTERMEDIATES PRODUCED BY PHAGOCYTIC CELLS. SEEMS REGULATED FT BY SIGB|Rv2710 [CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 FT H(2)O]." FT /EC_number="1.11.1.6" FT /note="Rv1908c, (MTCY180.10), len: 740 aa. katG, FT catalase-peroxidase-peroxynitritase T (EC 1.11.1.6) (see FT citations below), HPI. FASTA results: Q57215 FT CATALASE-PEROXIDASE from Mycobacterium tuberculosis (740 FT aa) opt: 5081, E(): 0, (100% identity in 740 aa overlap). FT Contains peroxidases active site signature (PS00436) and FT ATP/GTP-binding site motif A (P-loop; PS00017). Cosmid FT sequence was corrected to agree with a sequencing read from FT the H37Rv genome. DELETIONS OR DEFECTS IN KATG GENE CAUSE FT ISONIAZID (INH) RESISTANCE. BELONGS TO THE PEROXIDASE FT FAMILY. BACTERIAL PEROXIDASE/CATALASE SUBFAMILY. KATG FT TRANSCRIPTION SEEMS TO BE REGULATED BY FURA|Rv1909c FT PRODUCT. The catalase-peroxidase activity is associated FT with the amino-terminal domain but no definite function has FT been assigned to the carboxy-terminal domain. TBparse score FT is 0.923." FT /db_xref="GOA:Q08129" FT /db_xref="InterPro:IPR019793" FT /db_xref="PDB:1SFZ" FT /db_xref="UniProtKB/Swiss-Prot:Q08129" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10056.1" FT /translation="MPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNL FT KVLHQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIR FT MAWHAAGTYRIHDGRGGAGGGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWAD FT LIVFAGNCALESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAA FT VQMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGAGPA FT DLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTNTPTKWDNSFLEILYGYE FT WELTKSPAGAWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDLSLRVDPIYERITRRWLE FT HPEELADEFAKAWYKLIHRDMGPVARYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASL FT KSQIRASGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKV FT IRTLEEIQESFNSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQ FT EQTDVESFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEMTVLVGGLRVLG FT ANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKDGSGKVKWTGSRV FT DLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR" FT misc_feature complement(76584..76607) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(77079..77114) FT /note="PS00436 Peroxidases active site signature" FT CDS complement(77446..77898) FT /transl_table=11 FT /gene="furA" FT /locus_tag="Rv1909c" FT /product="FERRIC UPTAKE REGULATION PROTEIN FURA (FUR)" FT /function="ACTS AS A GLOBAL NEGATIVE CONTROLLING ELEMENT, FT EMPLOYING FE(2+) AS A COFACTOR TO BIND THE OPERATOR OF THE FT REPRESSED GENES. SEEMS TO REGULATE TRANSCRIPTION OF FT KATG|Rv1908c GENE." FT /note="Rv1909c, (MTCY180.09), len: 150 aa. furA, Ferric FT uptake regulation protein, similar to Q48835 LEGIONELLA FT PNEUMOPHILA 130B (WADSWORTH) FERRIC UPTAKE REGULATION (136 FT aa), FASTA results: opt: 230, E(): 2.5e-09, (32.3% identity FT in 133 aa overlap). Also similar to Mycobacterium FT tuberculosis furB ferric uptake regulatory protein, Rv2359. FT BELONGS TO THE FUR FAMILY." FT /db_xref="GOA:P0A582" FT /db_xref="InterPro:IPR002481" FT /db_xref="UniProtKB/Swiss-Prot:P0A582" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10055.1" FT /translation="MSSVSSIPDYAEQLRTADLRVTRPRVAVLEAVNAHPHADTETIFG FT AVRFALPDVSRQAVYDVLHALTAAGLVRKIQPSGSVARYESRVGDNHHHIVCRSCGVIA FT DVDCAVGEAPCLTASDHNGFLLDEAEVIYWGLCPDCSISDTSRSHP" FT CDS complement(78003..78596) FT /transl_table=11 FT /locus_tag="Rv1910c" FT /product="PROBABLE EXPORTED PROTEIN" FT /function="UNKNOWN" FT /note="Rv1910c, (MTCY180.08), len: 197 aa. Possible FT exported protein, very similar to upstream ORF MTCY180.07 FT (201 aa), FASTA score: E(): 0, (64.0% identity in 200 aa FT overlap). Also similar to Q9Z729|Y877_CHLPN PROTEIN CPN0877 FT from Chlamydophila pneumoniae (150 aa). TBparse score is FT 0.940." FT /db_xref="HSSP:1FUX" FT /db_xref="InterPro:IPR005247" FT /db_xref="UniProtKB/Swiss-Prot:P67222" FT /protein_id="CAB10054.1" FT /translation="MAHAFHRFALAILGLALPVALVAYGGNGDSRKAAPLAPKAAALGR FT SMPETPTGDVLTISSPAFADGAPIPEQYTCKGANIAPPLTWSAPFGGALVVDDPDAPRE FT PYVHWIVIGIAPGAGSTADGETPGGGISLPNSSGQPAYTGPCPPAGTGTHHYRFTLYHL FT PAVPPLAGLAGTQAARVIAQAATMQARLIGTYEG" FT CDS complement(78679..79284) FT /transl_table=11 FT /gene="lppC" FT /locus_tag="Rv1911c" FT /product="PROBABLE LIPOPROTEIN LPPC" FT /function="UNKNOWN" FT /note="Rv1911c, (MTCY180.07), len: 201 aa. Probable FT lipoprotein lppC, contains appropriately positioned FT prokaryotic membrane lipoprotein lipid attachment site FT (PS00013). Very similar to downstream ORF MTCY180.08 (204 FT aa) (although this lacks lipoprotein motif), FASTA score: FT opt: 831, E(): 0, (64.0% identity in 200 aa overlap). Also FT similar to Q9Z729|Y877_CHLPN HYPOTHETICAL PROTEIN CPN0877 FT from Chlamydia pneumoniae (strain CWL029) (150 aa). TBparse FT score is 0.940." FT /db_xref="InterPro:IPR005247" FT /db_xref="UniProtKB/Swiss-Prot:P67224" FT /protein_id="CAB10030.1" FT /translation="MTSTLHRTPLATAGLALVVALGGCGGGGGDSRETPPYVPKATTVD FT ATTPAPAAEPLTIASPMFADGAPIPVQFSCKGANVAPPLTWSSPAGAAELALVVDDPDA FT VGGLYVHWIVTGIAPGSGSTADGQTPAGGHSVPNSGGRQGYFGPCPPAGTGTHHYRFTL FT YHLPVALQLPPGATGVQAAQAIAQAASGQARLVGTFEG" FT misc_feature complement(79213..79245) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(79384..80388) FT /transl_table=11 FT /gene="fadB5" FT /locus_tag="Rv1912c" FT /product="POSSIBLE OXIDOREDUCTASE FADB5" FT /function="THOUGHT TO BE INVOLVED IN FATTY ACID FT DEGRADATION. FADB AND FADA ARE THE ALPHA AND BETA SUBUNITS FT OF THE MULTIFUNCTIONAL ENZYME COMPLEX OF THE FATTY ACID FT DEGRADATION CYCLE." FT /EC_number="1.-.-.-" FT /note="Rv1912c, (MTCY180.06), len: 334 aa. Possible fadB5, FT oxidoreductase (EC 1.-.-.-), similar to various FT oxidoreductases: 3-hydroxyacyl-CoA dehydrogenase (EC FT 1.1.1.35), quinone oxidoreductases (EC 1.6.5.5), and FT polyketide synthases, e.g. NP_104067.1|NC_002678 probable FT oxidoreductase from Mesorhizobium loti (308 aa); FT NP_464140.1|NC_003210 protein similar to oxidoreductase FT from Listeria monocytogenes (313 aa); NP_193889.1|NC_003075 FT putative NADPH quinone oxidoreductase from Arabidopsis FT thaliana (325 aa); NP_001880.2|NM_001889 crystallin, zeta; FT quinone oxidoreductase; NADPH:quinone reductase from Homo FT sapiens (329 aa); part 2983 to 3197 of T17410 polyketide FT synthase type I from Streptomyces venezuelae (3739 aa); FT Q53927|SCBAC20F6.16 HYDROXYACYL-CoA DEHYDROGENASE from FT Streptomyces coelicolor (329 aa), FASTA scores: opt: 621, FT E(): 2e-30, (39.5% identity in 349 aa overlap); etc. Also FT similar to many hypothetical Mycobacterium tuberculosis FT proteins including: MTCY24G1.09, MTCY13D12.11, MTCY19H9.01, FT MTCY24G1.03, MTCY03A2.17c, etc. Contains quinone FT oxidoreductase/zeta-crystallin signature (PS01162). TBparse FT score is 0.921." FT /db_xref="GOA:O07721" FT /db_xref="HSSP:1PQW" FT /db_xref="InterPro:IPR013154" FT /db_xref="UniProtKB/TrEMBL:O07721" FT /protein_id="CAB10029.1" FT /translation="MRAVVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFADH FT LARVGLYPDAPKLPAVVGYEVAGTVEAVGDGVDPNRVGERVLAGTRFGGYCEIVNVAAT FT DSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLRAGERVLIHAAAGGVGIAAVQFAKA FT AKAEVHGTASPQKHQKLAEFGVDRAIDYRRDGWWQGLGPYDVVLDALGGTSLRRSYTLL FT RPGGRLVGYGISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRLWDD FT RRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAPEAHRILAARENVDKVVLVP" FT misc_feature complement(79912..79965) FT /note="PS01162 Quinone oxidoreductase / zeta-crystallin FT signature" FT CDS 80488..81240 FT /transl_table=11 FT /locus_tag="Rv1913" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1913, (MTCY180.05c), len: 250 aa. Conserved FT hypothetical protein, slight similarity to dehydrase and FT beta-lactamase precursors e.g. Q02057 DEHYDRASE from FT Streptomyces coelicolor (297 aa), FASTA scores: opt: 184, FT E(): 4.3e-05, (31.6% identity in 215 aa overlap)." FT /db_xref="GOA:O07720" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:O07720" FT /protein_id="CAB10053.1" FT /translation="MHFDWERLTDSVHRCRLPFCDVTVGLVRGRTGILLVDTGTTLGEA FT TAIAADVKQIAGCQVTHVVLTHKHFDHVLGSSVFDQAEVFCAPEVVEYLRSATDRLRED FT ALSYGADTAEVDRAIAALKPPQHGIYDAAVDLGDRTVTITHPGSGHTTADLVVVAPATG FT HADGPTVVFTGDLVEESADPDIDADSDLAAWPATLDRVLAIGGPDASYVPGHGKVVDAQ FT FVRRQRAWLRTRASRQPRETPATLPCKR" FT CDS complement(81218..81625) FT /transl_table=11 FT /locus_tag="Rv1914c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1914c, (MTCY180.04), len: 135 aa. Hypothetical FT unknown protein, TBparse score is 0.924" FT /db_xref="UniProtKB/TrEMBL:O07719" FT /protein_id="CAB10028.1" FT /translation="MVLSRTSTGRVILVPTQLRFDRWFLPLAVPLGLGPKNSELWVGAG FT SLHVKMGWAFAADIPLTSITKAEATNARVYAAGVHFGFGRWLVNGSRKGLVALTIDPPE FT QAKMWKKSMTVRELWVSVTDPDALVTACTAK" FT CDS 81760..82863 FT /transl_table=11 FT /gene="aceAa" FT /locus_tag="Rv1915" FT /product="PROBABLE ISOCITRATE LYASE aceAa [FIRST PART] FT (ISOCITRASE) (ISOCITRATASE) (ICL)" FT /function="INVOLVED IN GLYOXYLATE BYPASS, AN ALTERNATIVE TO FT THE TRICARBOXYLIC ACID CYCLE [CATALYTIC ACTIVITY: FT ISOCITRATE = SUCCINATE + GLYOXYLATE]." FT /EC_number="4.1.3.1" FT /note="Rv1915, (MTCY180.03c), len: 367 aa. Probable aceAa, FT isocitrate lyase (EC 4.1.3.1) (see citations below). Highly FT similar to the N-terminus of ACEA_MYCLE ISOCITRATE LYASE FT (EC 4.1.3.1) from Mycobacterium leprae (606 aa), FASTA FT results: opt: 3314, E(): 0, (86.5% identity in 572 aa FT overlap). Contains PS00161 Isocitrate lyase signature. FT Although this ORF and the downstream ORF representing the FT C-terminal half of aceA could be joined by a frameshift, no FT error is apparent in the cosmid, or in a seqencing read FT from the genome of H37Rv. As the downstream ORF has a RBS FT and transcriptional start immediately following the stop of FT this ORF, it is possible that they are expressed as two FT separate modules. In Mycobacterium tuberculosis strain FT CDC1551, aceA exists as a single gene, MT1966: the FT corresponding protein has been purified experimentally and FT seems have an active isocitrate lyase activity (see Honer FT et al., 1999). For Mycobacterium tuberculosis strain H37Rv, FT immunoblot assay didn't detect AceAa or AceAb products (see FT Honer et al., 1999) but mRNA of AceAa|Rv1915 has been FT detected (see Betts et al., 2002); so AceAb|Rv1916 could be FT a pseudogene." FT /db_xref="GOA:O07718" FT /db_xref="HSSP:1DQU" FT /db_xref="InterPro:IPR018523" FT /db_xref="UniProtKB/TrEMBL:O07718" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10027.1" FT /translation="MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQ FT VVEQRGTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIY FT LGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRA FT ATPAYDFRPFIIADAGTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKV FT LVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDV FT PSYKSCFLAMVRRFTNWASRSSMVIFSMRLATASTRRPAVGLSAKAFSAWSPTRSTRGG FT RTASSRSTAFSTRSSRGSWRPGRTTRA" FT misc_feature 82396..82413 FT /note="PS00161 Isocitrate lyase signature" FT CDS 82863..84059 FT /transl_table=11 FT /gene="aceAb" FT /locus_tag="Rv1916" FT /product="PROBABLE ISOCITRATE LYASE aceAb [SECOND PART] FT (ISOCITRASE) (ISOCITRATASE) (ICL)" FT /function="INVOLVED IN GLYOXYLATE BYPASS, AN ALTERNATIVE TO FT THE TRICARBOXYLIC ACID CYCLE [CATALYTIC ACTIVITY: FT ISOCITRATE = SUCCINATE + GLYOXYLATE]." FT /EC_number="4.1.3.1" FT /note="Rv1916, (MTCY180.02c), len: 398 aa. Probable aceAb, FT isocitrate lyase (EC 4.1.3.1) (see citations below). Highly FT similar to the C-terminus of ACEA_MYCLE|P46831 isocitrate FT lyase (EC 4.1.3.1) from Mycobacterium leprae (606 aa), FT FASTA results: opt: 1635, E(): 0, (86.3% identity in 278 aa FT overlap). Although this ORF and the upstream ORF FT representing the N-terminal half of aceA could be joined by FT a frameshift no error is apparent in the cosmid, or in a FT seqencing read from the genome of H37Rv. As this ORF has a FT RBS and transcriptional start immediately following the FT stop of the upstream ORF, it is possible that they are FT expressed as two separate modules. In Mycobacterium FT tuberculosis strain CDC1551, aceA exists as a single gene, FT MT1966: the corresponding protein has been purified FT experimentally and seems have an active isocitrate lyase FT activity (see Honer et al., 1999). For Mycobacterium FT tuberculosis strain H37Rv, immunoblot assay didn't detect FT AceAa or AceAb products (see Honer et al., 1999) but mRNA FT of AceAa|Rv1915 has been detected (see Betts et al., 2002); FT so AceAb|Rv1916 could be a pseudogene." FT /db_xref="GOA:O07717" FT /db_xref="HSSP:1IGW" FT /db_xref="InterPro:IPR006254" FT /db_xref="UniProtKB/TrEMBL:O07717" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10026.1" FT /translation="MTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAK FT ELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFA FT EAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGV FT AAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKA FT MGKGSTQHQHLVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGE FT SDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYV FT TPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA" FT CDS complement(84229..88608) FT /transl_table=11 FT /gene="PPE34" FT /locus_tag="Rv1917c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1917c, (MTV050.01c-MTCY180.01), len: 1459 aa. FT Member of the Mycobacterium tuberculosis PPE family of FT glycine-rich proteins, MPTR subfamily (see citation below). FT Similar to MTCY28.16, MTCY13E10.17, MTCY63.10, MTV004.05 , FT MTCY98.24, MTCY6G11.05, etc. C-terminus is identical to FT Q50471. Unknown Mycobacterium tuberculosis protein (693 FT aa), FASTA results: opt: 2635, E(): 0, (99.7% identity in FT 391 aa overlap). Start changed since original submission FT (+23 aa). Thougth to be surface exposed, cell-wall FT associated." FT /db_xref="InterPro:IPR000183" FT /db_xref="UniProtKB/TrEMBL:Q79FI9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55440.1" FT /translation="MNFSTLPPEINSALIFGGAGSEPMSAAAVAWDQLAMELASAAASF FT NSVTSGLVGESWLGPSSAAMAAAVAPYLGWLAAAAAQAQRSATQAAALVAEFEAVRAAM FT VQPALVAANRSDLVSLVFSNFFGQNAPAIAAIEAAYEQMWAIDVSVMSAYHAGASAVAS FT ALTPFTAPPQNLTDLPAQLAAAPAAVVTAAITSSKGVLANLSLGLANSGFGQMGAANLG FT ILNLGSLNPGGNNFGLGNVGSNNVGLGNTGNGNIGFGNTGNGNIGFGLTGDNQQGFGGW FT NSGTGNIGLFNSGTGNIGIGNTGTGNFGIGNSGTSYNTGIGNTGQANTGFFNAGIANTG FT IGNTGNYNTGSFNLGSFNTGDFNTGSSNTGFFNPGNLNTGVGNTGNVNTGGFNSGNYSN FT GFFWRGDYQGLIGFSGTLTIPAAGLDLNGLGSVGPITIPSITIPEIGLGINSSGALVGP FT INVPPITVPAIGLGINSTGALVGPINIPPITLNSIGLELSAFQVINVGSISIPASPLAI FT GLFGVNPTVGSIGPGSISIQLGTPEIPAIPPFFPGFPPDYVTVSGQIGPITFLSGGYSL FT PAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDV FT GGGLGPFTVFPDGYSLPAIPLGIDVGGAIGPLTTPPITIPSIPLGIDVSGSLGPINIPI FT EIAGTPGFGNSTTTPSSGFFNSGTGGTSGFGNVGSGGSGFWNIAGNLGNSGFLNVGPLT FT SGILNFGNTVSGLYNTSTLGLATSAFHSGVGNTDSQLAGFMRNAAGGTLFNFGFANDGT FT LNLGNANLGDYNVGSGNVGSYNFGSGNIGNGSFGFGNIGSNNFGFGNVGSNNLGFANTG FT PGLTEALHNIGFGNIGGNNYGFANIGNGNIGFGNTGTGNIGIGLTGDNQVGFGALNSGS FT GNIGFFNSGNGNIGFFNSGNGNVGIGNSGNYNTGLGNVGNANTGLFNTGNVNTGIGNAG FT SYNTGSYNAGDTNTGDLNPGNANTGYLNLGDLNTGWGNIGDLNTGALISGSYSNGILWR FT GDYQGLIGYSDTLSIPAIPLSVEVNGGIGPIVVPDITIPGIPLSLNALGGVGPIVVPDI FT TIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALG FT GVGPIVVPDITIPGIPLSLNALGGVGPITVPGVPISRIPLTINIRIPVNITLNELPFNV FT AGIFTGYIGPIPLSTFVLGVTLAGGTLESGIQGFSVNPFGLNIPLSGATNAVTIPGFAI FT NPFGLNVPLSGGTSPVTIPGFAINPFGLNVPLSGGTSPVTIPGFTIPGSPLNLTANGGL FT GPINIPINITSAPGFGNSTTTPSSGFFNSGDGSASGFGNVGPGISGLWNQVPNALQGGV FT SGIYNVGQLASGVANLGNTVSGFNNTSTVGHLTAAFNSGVNNIGQMLLGFFSPGAGP" FT repeat_region complement(84620..84689) FT /note="69 bp imperfect direct repeat 3, FT TTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCC FT CCGGCTTCACCAT" FT repeat_region complement(84690..84758) FT /note="69 bp imperfect direct repeat 2, FT TTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCC FT CTGGTTTCGCGA" FT repeat_region complement(84759..84827) FT /note="69 bp imperfect direct repeat 1, FT TTAATCCGTTCGGTTTGAATATTCCGCTGAGCGGTGCTACCAACGCTGTCACGATCC FT CTGGTTTCGCGA" FT repeat_region complement(85038..85106) FT /note="69 bp imperfect direct repeat 5, FT TCGGTCCGATTGTGGTGCCTGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACG FT CGCTGGGTGGTG" FT repeat_region complement(85107..85175) FT /note="69 bp imperfect direct repeat 4, FT TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACG FT CGCTGGGTGGTG" FT repeat_region complement(85176..85244) FT /note="69 bp imperfect direct repeat 3, FT TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACG FT CGCTGGGTGGTG" FT repeat_region complement(85245..85313) FT /note="69 bp imperfect direct repeat 2, FT TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACG FT CGCTGGGTGGTG" FT repeat_region complement(85314..85382) FT /note="69 bp imperfect direct repeat 1, FT TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACG FT CGCTGGGTGGTG" FT misc_feature complement(86689..86742) FT /note="PS00879 Orn/DAP/Arg decarboxylases family 2 FT signature 2" FT misc_feature complement(86764..86817) FT /note="PS00879 Orn/DAP/Arg decarboxylases family 2 FT signature 2" FT misc_feature complement(86839..86892) FT /note="PS00879 Orn/DAP/Arg decarboxylases family 2 FT signature 2" FT CDS complement(88946..91909) FT /transl_table=11 FT /gene="PPE35" FT /locus_tag="Rv1918c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1918c, (MTV050.02c), len: 987 aa. Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins. Similar to MTCY28.16|Z95890 Mycobacterium FT tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404, FT E(): 0, (65.6% identity in 1058 aa overlap). Also similar FT to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23, FT MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36, FT MTCY180.01, etc." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q79FI8" FT /protein_id="CAE55441.1" FT /translation="MHYSVLPPEINSALIFAGAGSGPMLAAASAWDGLATELASAAVSF FT GSVTAGLVGGSWQGRSSVAMAAAAAPYAGWLAAAATQAEQAATQAQVMVAEFEAVRLAM FT VQPALVAANRSGLISLVISNLFGQNAPAIAAAEAAYEEMWALDVSAMAAYHSGASAVAV FT ALPAFALPLRLPAGLAAGPAAVVTALTTAVGMPTFAGRAIAASLGLANVGGGNLGNANN FT GLGNIGNANLGNNNLGSGNFGSFNIGSANLGGNNIGIGNAGANNFGLANLGNLNTGFAN FT AGIGNFGIANTGNNNIGNGLTGNNQIGIGGLNSGNGNVGLFNAGSANIGFFNSGNGNFG FT IGNSGNFSTGLFNPGHGNTGFLNAGSFNTGMFDVGNANTGSFNVGHYNFGAFNPGPSNT FT GTFNTGGANTGWFNTGSINTGAFNIGDMNNGLFNTGDMNNGVFYRGVGQGSLQFAITSP FT DLTLPSLEIPGISVPAFSLPAITLPSLTIPAVTTPANVTVGAFDLPGLTVPSLTIPAAM FT TPANITVGAFDLPGLTVPSLTIPATTTPANITVGAFNLPQLSIPSVTVPPITIPAGTAL FT GAFNLPTLSIPSVTVPPITIPAGTTVGGFTLPTIHTPLISTPQISIGGFSTPGIATQAN FT SGVINLPTFSLNGITITNLVVFIPNNITALQTNMPGVFPQIGGFANTPPAFINTGTITV FT GGGQINGVGFSIGAINVTPFTLPNVVIQPWSLGGISVDGFTLPEISTQEFTTPALTISP FT IGVGALSLPDITTQQFTTPELTIDPITLGGFTLPQLSIPAITTPAFTIDPIALGGFTLP FT QIMTPEITTPPFAIDPIGLSGFTLPQVNIPEITTPEFTIQPVGLAAFTTPALTIASIHL FT PSTTMGGFAIPAGPGYFNSSATPSLGFFNAGIGGNSGFGNSGSGLSGWFNTSPVGLLAG FT SGYQNYGGLISGFSNLGSGISGFANTGTLPFAVTSLVSGLANIGNNLSGLFFQSTTP" FT CDS complement(92358..92822) FT /transl_table=11 FT /locus_tag="Rv1919c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1919c, (MTV050.03c), len: 154 aa. Conserved FT hypothetical protein, shows weak similarity to several FT major pollen antigens e.g. Z72431|BVGC25_1 MAJOR ALLERGEN FT BET V 1 from Betula verrucosa (160 aa), FASTA scores: opt: FT 133, E(): 0.012, (26.8% identity in 149 aa overlap). Also FT shows some similarity to Rv2574|MTCY227.27C Hypothetical FT protein from Mycobacterium tuberculosis (167 aa), (27.4% FT identity in 124 aa overlap)." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/TrEMBL:O53961" FT /protein_id="CAA17698.1" FT /translation="MSGRKFSFEVTKTSSAPAATLFRLVTDGGNWATWAKPIVAQSSWA FT RRGDPAPGGIGAIRKLGMWPVFVQEETVEYEQDRRHVYKLVGARTPVQDYFGEVVLTPN FT ASGGTDLRWSGSFTEKVRGTGPVMRAALGGAVRFFAGQLVKAAEREAVRR" FT CDS 92920..93783 FT /transl_table=11 FT /locus_tag="Rv1920" FT /product="PROBABLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1920, (MTV050.04), len: 287 aa. Probable membrane FT protein, similar to AL0215|SC10A5.04 putative membrane FT protein from Streptomyces coelicolor cosmid 10A5 (295 aa), FT FASTA scores: opt: 292, E(): 3.6e-13, (31.3% identity in FT 243 aa overlap). Also weakly similar to several FT Mycobacterial putative proteins with unknown function e.g. FT Rv0502, Rv1428c, U00018_22 Mycobacterium leprae cosmid FT B2168." FT /db_xref="GOA:O53962" FT /db_xref="InterPro:IPR016676" FT /db_xref="UniProtKB/TrEMBL:O53962" FT /protein_id="CAA17699.1" FT /translation="MFPRWPQQAHNHEVSRADTVSVPRAPTQAEVAAVLRIMTPLRKVI FT KPKVYGIENVPTERALLVGNHNTLGLVDAPLLAAELWERGRIVRSLGDHAHFKIPGWRD FT ALTRTGVVEGTREITSELMRRGELVMVFPGGAREVNKRKNERYKLVWKNRLGFARLAIQ FT HGYPIVPFASVGAEHGIDIVLDNESPLLAPVQFLAEKLLGTKDGPALVRGVGLTPVPRP FT ERQYYWFGEPIDTTEFMGQQADDNAARRVRERAAAAIEHGIELMLAERAADPNRSLVGR FT LLRSDA" FT CDS complement(93821..95092) FT /transl_table=11 FT /gene="lppF" FT /locus_tag="Rv1921c" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPPF" FT /function="UNKNOWN" FT /note="Rv1921c, (MTCY09F9.43-MTV050.05c), len: 423 aa. FT Probable lppF, conserved lipoprotein, similar to G403173 FT lipoprotein precursor (fragment) from Rhodococcus FT erythropolis (225 aa), fasta scores: opt: 364, E(): FT 9.2e-19, (41.9% identity in 148 aa overlap). Contains FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site." FT /db_xref="UniProtKB/TrEMBL:O53963" FT /protein_id="CAA17700.1" FT /translation="MVRLIPSLLAMATVLGGVIGCSAHQPPTPASGCRQLDAFLKWHHG FT VREFLQSAIDANSRCTGTADGSARKVAIFDWDNTVVKNDIGYATNYYMLQHSLVLQPAN FT QDWHAASRYLTDAAANALSVACGKVVPAGKPLPTGSNALCANEILSLLDGETTTGQPAF FT VGNNVRRLAGPYAWSNALSAGYTAEELAGFADQAKKQNLAADVGATQQVGTQQVDGYIR FT VYPQMKDLIGTLQAHGIDTWVVSASPEPIVKVWAGEVGLDDQHVVGVRSVADQSGKLTA FT HLVGCGGVRDGDDSVMTYLDGKRCWANQVIFGVTGPQAFNQLAADRRQVLAAGDSNSDA FT TFVGDATVVSLVINRNQDDLMCRAYDGLFTRGGKWAINPMFIDPLPQHAPYVCGEAFIN FT PDGSKQPVLRNDGTPIPDQVDSVF" FT misc_feature complement(95030..95062) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 95364..96479 FT /transl_table=11 FT /locus_tag="Rv1922" FT /product="PROBABLE CONSERVED LIPOPROTEIN" FT /function="UNKNOWN" FT /note="Rv1922, (MTCY09F9.42c), len: 371 aa. Probable FT conserved lipoprotein, possibly peptidase (EC 3.4.-.-) FT similar to many peptidases, e.g. P15555|DAC_STRSQ FT D-alanyl-D-alanine carboxypeptidase from Streptomyces sp. FT (406 aa), FASTA scores: opt: 382, E(): 3.1e-17, (28.0% FT identity in 379 aa overlap). Also similar to Mycobacterium FT tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, FT etc. Contains PS00013 Prokaryotic membrane lipoprotein FT lipid attachment site." FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:P95291" FT /protein_id="CAB06504.1" FT /translation="MDSTVTASIRRMLGLLAATLLLGGCTGQHTTRTAASTTYTPHIKA FT SSQDVLDGAINADEPGCSAAVGVEGKVIWSGVRGIADLASGAKITTDTVFDIASVSKQF FT TATAILLLVEAGKLTLDDPISQYVPELPDWAQTVTVEQLMHQTSGIPDYVALLAARGYQ FT VSDRTIEAEARQALAAAPELQFKPGTRFDYSNSNYLLLGEIVHRASGQPLPEFLSAEIF FT QPLGLAMVVDPVGKVPNKAVSYEKGTGGNRSEYRVGNPAWEQIGDGGIQTTPSQLARWA FT DNYRTGSVGGLKLLEAQLAGAVETEPGGGDRYGAGIVSRADGTLDHAGAWAGFVTAFHI FT SSDRRTSVAISCNTDKPDPVAMADALGRLWM" FT misc_feature 95406..95438 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 96470..97810 FT /transl_table=11 FT /gene="lipD" FT /locus_tag="Rv1923" FT /product="PROBABLE LIPASE LIPD" FT /function="UNKNOWN; LIPOLYTIC ENZYME PROBABLY INVOLVED IN FT CELLULAR METABOLISM" FT /EC_number="3.1.-.-" FT /note="Rv1923, (MTCY09F9.41c), len: 446 aa. Probable lipD, FT hydrolase lipase (EC 3.1.-.-), similar to esterases and FT beta-lactamases e.g. G151214 esterase, (389 aa), fasta FT scores: opt: 569, E(): 5.4e-29, (33.7% identity in 401 aa FT overlap). Also similar to Mycobacterium tuberculosis FT hypothetical proteins Rv1497, Rv2463, Rv3775, etc." FT /db_xref="GOA:P95290" FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:P95290" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06503.1" FT /translation="MDVAGLPRLAAGTQAAIIHGMAQPPSLLTTDNGLPFGVQGACDSR FT FTGVIRAFAGLYPGRKFGGGALSVYIDGRQVVDVWTGWSDRQGKVPWTADTGAMVFSAT FT KGLAATVIHRLVDRGLLSYDAPVAEYWPEFGANGKSEVTVSDVLRHRSGLAHLKGVDKD FT EVMDHLLMEQKLAAAPLDRQHGKLAYHAVTYGWLLSGLARAVTGKGMRELFREELARPL FT NTDGIHLGRPPADSPTKAAQTLLPQAKVPTPLLDFIAPKVAGLSFSGLLGAVYFPGILS FT LLQDDMPFLDGEVPAVNGVVTARALAKTYGALANDGVIDGTRLLSSQAVRGLTGKSELW FT PDLNLGLPFTYHQGYQSSPVPGLLEGYGHIGLGGTIGWADPETGSAFGYVHNRLLTLLL FT FDIGSFAGLAALLNSAVVAARRDDPLEVPHFGAPYSEPRHEQAASGA" FT CDS complement(97847..98227) FT /transl_table=11 FT /locus_tag="Rv1924c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1924c, (MTCY09F9.40), len: 126 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P95289" FT /protein_id="CAB06502.1" FT /translation="MDPADVINPTSTRDAALARVLAYRQRVRARPLLIRATLAVVGGGL FT FVVSLPMIVLLPELGIPALLVAFRLLAVEAQWAVRAYAWTDWRFTQLREWFHRQVLVTR FT AAILVGLFLAAVALVWLLVYEF" FT CDS 98384..100246 FT /transl_table=11 FT /gene="fadD31" FT /locus_tag="Rv1925" FT /product="PROBABLE ACYL-CoA LIGASE FADD31 (ACYL-COA FT SYNTHETASE) (ACYL-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv1925, (MTCY09F9.39c), len: 620 aa. Probable FT fadD31, acyl-CoA synthetase (EC 6.2.1.-), highly similar to FT others from Mycobacterium leprae e.g. NP_301198.1|NC_002677 FT putative acyl-CoA synthetase (635 aa); FT NP_302537.1|NC_002677 probable acyl-CoA synthase (583 aa); FT etc. Also highly similar to others from Mycobacterium FT tuberculosis e.g. fadD32 (637 aa); fadD21 (578 aa); fadD29 FT (619 aa); fadD26|FD26_MYCTU|Q10976 (626 aa), FASTA scores: FT opt: 945, E(): 0, (39.8% identity in 598 aa overlap); etc. FT Also similar to N-terminus of G1171128 SAFRAMYCIN MX1 FT SYNTHETASE B from Myxococcus xanthus (1770 aa), FASTA FT scores: opt: 845, E(): 0, (37.4% identity in 593 aa FT overlap); N-terminus of T34918 polyketide synthase from FT Streptomyces coelicolor (2297 aa); etc." FT /db_xref="GOA:P95288" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:P95288" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06501.1" FT /translation="MNDGSRQELRVRSGLLQIEDCLDADGGIALPAGTTLISLIERNIK FT YVGDLVAYRYLDHARSAAGCALEVTWTQFGMRLAAIGAHVQRFAGPGDRVAILAPQGID FT YVCGFYAAIKAGTVAVPLFAPELPGHAERLDTALRDSEPAVILTTAAAKNAVEGFLNNV FT PRLRKPTVLVIDQIPDREGELFVPVEMDIDAVSHLQYTSGSTRPPVGVEITHRAVGTNL FT VQMILSIDLLNRNTHGVSWLPLYHDMGLSMIGFPAVYGGHSTLMSPTAFVRRPLRWIQA FT LSEGSRTGRVVTAAPNFAYEWAAQRGLPAQGDDVDLSNVVLIIGSEPVSIDAVTTFNKA FT FAPYGLPRTAFKPSYGIAEATLLVATIDHAAEPTVVYLDPEQLGAGHATRVAPDAPNAV FT VHVSCGHVARSLWAVIVDPDTGPEAGAELPDGEIGEVWLQGDNVARGYWGRPEETRMTF FT GARLQSPLAEGSHADGSAIDDTWLRTGDLGVYLDGELYITGRIADLLTIDGRNHYPQDI FT EATAAEASPMVRRGYITAFTVPASDGDDRNQRLVIIAERAAGTSRSDPRPALDAIRAAV FT CNRHGLSVADLSFLPAGAIPRTTSGKLARQACRAQYLSGRLGVH" FT CDS complement(100254..100733) FT /transl_table=11 FT /gene="mpt63" FT /locus_tag="Rv1926c" FT /standard_name="mpb63" FT /product="IMMUNOGENIC PROTEIN MPT63 (ANTIGEN MPT63/MPB63) FT (16 kDa IMMUNOPROTECTIVE EXTRACELLULAR PROTEIN)" FT /function="UNKNOWN" FT /note="Rv1926c, (MT1977, MTCY09F9.38), len: 159 aa. mpt63 FT (alternate gene name: mpb63), immunogenic protein (see FT citations below), identical to MPT63|MPB63 from FT Mycobacterium bovis (159 aa). Exported protein containing a FT N-terminal signal sequence: see notes below about FT proteomics." FT /db_xref="GOA:P0A5Q2" FT /db_xref="InterPro:IPR015250" FT /db_xref="PDB:1LMI" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Q2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06500.1" FT /translation="MKLTTMIKTAVAVVAMAAIATFAAPVALAAYPITGKLGSELTMTD FT TVGQVVLGWKVSDLKSSTAVIPGYPVAGQVWEATATVNAIRGSVTPAVSQFNARTADGI FT NYRVLWQAAGPDTISGATIPQGEQSTGKIYFDVTGPSPTIVAMNNGMEDLLIWEP" FT CDS 100970..101743 FT /transl_table=11 FT /locus_tag="Rv1927" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1927, (MTCY09F9.37c), len: 257 aa. Conserved FT hypothetical protein, similar to SCG11A.10c|AL133210 FT hypothetical protein from Streptomyces coelicolor (252 aa), FT FASTA scores: opt: 729, E(): 0, (48.3% identity in 238 aa FT overlap). Slight similarity with P54543|YQJF_BACSU FT hypothetical 23.9 kDa protein from Bacillus subtilis (209 FT aa), FASTA scores, opt: 230, E(): 2.8e-08, (28.0% identity FT in 164 aa overlap)." FT /db_xref="InterPro:IPR018644" FT /db_xref="UniProtKB/TrEMBL:P95287" FT /protein_id="CAB06499.1" FT /translation="MTAIPGPSGAEPGESRALAGYPVTPPALPRPVIFDQRWTDLTFIH FT WPVLPESVAGSYPPGTRPDVFADGMTYVGLVPFRMSSTKLGTALPIPYVGTFPETNVRL FT YSIDNAGRHGVLFRSLETARLTVVPLTRIGLGIPYAWSRMRMMRSGKHITYHSVRRWPR FT RGLRSLLTITIGDLVEPTPLEVWLTARWGAHTRKAGRTWWVPNEHKPWPLRAAEIAELN FT DELIDASGVQPTGDRLRALFSPGVHARFGRPCVVQ" FT CDS complement(101747..102514) FT /transl_table=11 FT /locus_tag="Rv1928c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv1928c, (MTCY09F9.36), len: 255 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), highly FT similar to others e.g. NP_228109.1|NC_000853 oxidoreductase FT (short chain dehydrogenase/reductase family) from FT Thermotoga maritima (257 aa); T41116 short chain FT dehydrogenase from Schizosaccharomyces pombe (261 aa); FT P87219|SOU1_CANAL SORBITOL UTILIZATION PROTEIN (SDR FAMILY) FT from Candida albicans (281 aa); P25529|HDHA_ECOLI FT 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli FT (255 aa), FASTA scores: opt: 541, E(): 1.2e-27, (37.5% FT identity in 251 aa overlap); etc. Also similar to many FT mycobacterial tuberculosis proteins e.g. Rv1350, Rv0927c, FT Rv2002, Rv0769, Rv2766c, etc. Contains PS00061 Short-chain FT alcohol dehydrogenase family signature. BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P95286" FT /db_xref="HSSP:1FJH" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95286" FT /protein_id="CAB06498.1" FT /translation="MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHL FT DALEKLADEIGTSGGKVVPVCCDVSQHQQVTSMLDQVTAELGGIDIAVCNAGIITVTPM FT LDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQGGVIINTASMSGHIINVPQQVSHY FT CASKAAVIHLTKAMAVELAPHKIRVNSVSPGYILTELVEPYTEYQPLWEPKIPLGRLGR FT PEELAGLYLYLASEASSYMTGSDIVIDGGYTCP" FT misc_feature complement(101981..102067) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS complement(102559..103203) FT /transl_table=11 FT /locus_tag="Rv1929c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1929c, MTCY09F9.35, len: 214 aa. Conserved FT hypothetical protein, similar to SC4G6.14|AL096884 FT hypothetical protein from Streptomyces coelicolor (211 aa), FT FASTA scores: opt: 416, E(): 2.4e-22, (39.8% identity in FT 206 aa overlap)." FT /db_xref="InterPro:IPR017519" FT /db_xref="UniProtKB/TrEMBL:P95285" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06497.1" FT /translation="MADVPLDAQERLELCDLLEELGPAVATLIEGWTAHDLAAHIVLRE FT RDLVAGLCIVLPGPFQRFAERRRARLAQSKDFTWLVARIRSGPPMGFFRIGWVRTLANL FT NEFFVHHEDVRRASGRGPRSLTPEMDAALWRNVRRGSHFLSRRLHGCGLEIEWVGTGKR FT VRVRSGEPTARLTGPPGELLLYVFGRRAVARVEVSGPLEAIAAVHRTHFGM" FT CDS complement(103215..103739) FT /transl_table=11 FT /locus_tag="Rv1930c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1930c, MTCY09F9.34, len: 174 aa. Conserved FT hypothetical protein, similar to SC5F2A.30|AL049587 FT hypothetical protein from Streptomyces coelicolor (211 aa), FT FASTA scores: opt: 307, E(): 2.8e-13, (54.8% identity in 84 FT aa overlap). Some similarity to M. tuber culosis FT hypothetical protein Rv0052|MTCY21D4.15 (43% identity in 93 FT aa overlap)." FT /db_xref="InterPro:IPR002818" FT /db_xref="UniProtKB/TrEMBL:P95284" FT /protein_id="CAB06496.1" FT /translation="MTQIAFVAYPGVTALDVVGPYEVLRNLPHAQVRFVWLRGRRATSH FT WLTLPALKAFGAIPVADERIVHQDNIVTSAGVSAGLDLALWLAGQLGGEARAKAIQLAI FT EYDPQPPFDSGHMSKASPTTKAAATALLSKDSAKPANLTAATLLAWERALAAVQSRRRK FT RQPVGAQARRP" FT CDS complement(103757..104536) FT /transl_table=11 FT /locus_tag="Rv1931c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1931c, (MTCY09F9.33), len: 259 aa. Probable FT transcriptional regulatory protein. Similarity in FT C-terminal half to transcriptional activators e.g. Q43970 FT ARAC-LIKE PROTEIN (227 aa), FASTA scores: opt: 238, E(): FT 7.1e-07, (42.4% identity in 92 aa overlap). Similar to many FT probable transcription regulators in Streptomyces e.g. FT AL049587|SC5F2A.29 Streptomyces coelicolor (325 aa), FASTA FT scores: opt: 387, E(): 3.2e-16, (34.4% identity in 259 aa FT overlap)." FT /db_xref="GOA:P95283" FT /db_xref="InterPro:IPR018060" FT /db_xref="UniProtKB/TrEMBL:P95283" FT /protein_id="CAB06530.1" FT /translation="MVIVGFPGDPVDTVILPGGAGVDAARSEPALIDWVKAVSGTARRV FT VTVCTGAFLAAEAGLLGRTPSDDALGLCRTFRPRISGRSGRCRPDLHAQFAEGVDRGWS FT HRRHRPRAGTGRRRPRHRDCPDGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAG FT GHRGRAGGAHRIGELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHD FT TVVAIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA" FT CDS 104669..105166 FT /transl_table=11 FT /gene="tpx" FT /locus_tag="Rv1932" FT /standard_name="cfp20" FT /product="PROBABLE THIOL PEROXIDASE TPX" FT /function="HAS ANTIOXIDANT ACTIVITY. COULD REMOVE PEROXIDES FT OR H(2)O(2)" FT /EC_number="1.11.1.-" FT /note="Rv1932, (MTCY09F9.32c), len: 165 aa. Probable tpx FT (alternate gene name: cfp20), thiol peroxidase (EC FT 1.11.1.-) similar to TPX_ECOLI|P37901 thiol peroxidase (EC FT 1.11.1.-) (p20) from Escherichia coli (167 aa), fasta FT scores: opt: 535, E(): 7.3e-25, (52.4% identity in 164 aa FT overlap). There are four other related enzymes in M. FT tuberculosis: Rv2428, Rv2521, Rv2238c, Rv1608c." FT /db_xref="GOA:P66952" FT /db_xref="InterPro:IPR002065" FT /db_xref="PDB:1XVQ" FT /db_xref="UniProtKB/Swiss-Prot:P66952" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06529.1" FT /translation="MAQITLRGNAINTVGELPAVGSPAPAFTLTGGDLGVISSDQFRGK FT SVLLNIFPSVDTPVCATSVRTFDERAAASGATVLCVSKDLPFAQKRFCGAEGTENVMPA FT SAFRDSFGEDYGVTIADGPMAGLLARAIVVIGADGNVAYTELVPEIAQEPNYEAALAAL FT GA" FT CDS complement(105163..106254) FT /transl_table=11 FT /gene="fadE18" FT /locus_tag="Rv1933c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE18" FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID FT DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv1933c, (MTCY09F9.31), len: 363 aa. Probable FT fadE18, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. CAB61609.1|AL133210 putative acyl-CoA FT dehydrogenase from Streptomyces coelicolor (362 aa); FT NP_421282.1|NC_002696 acyl-CoA dehydrogenase family protein FT from Caulobacter crescentus (344 aa); ACDS_RAT|P15651 FT short-chain specific acyl-CoA dehydrogenase from Rattus FT norvegicus (Rat) (412 aa), fasta scores: opt: 239, E(): FT 2.1e-08, (28.4% identity in 331 aa overlap); etc. Also FT similar to others from Mycobacterium tuberculosis e.g. FT N-terminus of fadE22 (721 aa); fadE33 (318 aa); N-terminus FT of fadE34 (711 aa); etc. COULD BELONG TO THE ACYL-CoA FT DEHYDROGENASES FAMILY." FT /db_xref="GOA:P95281" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:P95281" FT /protein_id="CAB06528.1" FT /translation="MDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSDRRLWQRLCT FT ELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAATVFAIEAILRMGDDEQRK FT RLLAGLLTGARIGTIAVSGHDVASATTVRAVRRDGRPALTGECTPVLHGHVADLFVVPA FT VADGSIVLHVVAADAPGVTVTPLPSFDITRPVATLRLAGSPAEPLTAGTPDDMERVLDV FT ARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVM FT FAAMSAANGDELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTT FT EALFGSSARNRALLAERAGLVKA" FT CDS complement(106256..107485) FT /transl_table=11 FT /gene="fadE17" FT /locus_tag="Rv1934c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE17" FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID FT DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv1934c, (MTCY09F9.30), len: 409 aa. Probable FT fadE17, acyl-CoA dehydrogenase (EC 1.3.99.-), highly FT similar to ACD_MYCLE|P46703 acyl-CoA dehydrogenase from FT Mycobacterium leprae (389 aa), FASTA scores: opt: 414, E(): FT 2.6e-19, (28.3% identity in 407 aa overlap). Also similar FT to many e.g. NP_249713.1|NC_002516 probable acyl-CoA FT dehydrogenase from Pseudomonas aeruginosa (381 aa); FT NP_420614.1|NC_002696 acyl-CoA dehydrogenase family protein FT from Caulobacter crescentus (355 aa); CAB61610.1|AL133210 FT putative acyl-CoA dehydrogenase from Streptomyces FT coelicolor (393 aa); etc. Also similar to others from FT Mycobacterium tuberculosis e.g. fadE30 (385 aa); fadE31 FT (377 aa); C-terminus of fadE34 (711 aa); etc. COULD BELONG FT TO THE ACYL-CoA DEHYDROGENASES FAMILY." FT /db_xref="GOA:P95280" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:P95280" FT /protein_id="CAB06527.1" FT /translation="MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHEREEFARH FT WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLLGIDLLGNTL FT IALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRTRGVLDGDEWVINGHKIWT FT SAGTTANWIFLLARTDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGHSSFSEVFLTDA FT RTSAGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHTDPRV FT RDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRRYTDLAVEILGL FT EALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARAATIYAGSSQIQRNVIGERLLGL FT PKEPRPEVLC" FT CDS complement(107500..108456) FT /transl_table=11 FT /gene="echA13" FT /locus_tag="Rv1935c" FT /product="POSSIBLE ENOYL-CoA HYDRATASE ECHA13 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS (BY SIMILARITY) [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv1935c, (MTCY09F9.29), len: 318 aa. Possible FT echA13, enoyl-CoA hydratase (EC 4.2.1.17), similar to FT others and various enzymes e.g. CAC48381.1|Y16952 putative FT enoyl-CoA-isomerase from Amycolatopsis mediterranei (269 FT aa); AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA FT hydratase from Pseudomonas putida (257 aa); FT AAF78820.1|AF042490 4-chlorobenzoyl CoA dehalogenase from FT Arthrobacter sp. TM1 (276 aa); ECHM_RAT|P14604 enoyl-coa FT hydratase mitochondrial precursor from Rattus norvegicus FT (Rat) (290 aa), FASTA scores: opt: 228, E( ): 1.2e-08, FT (31.0% identity in 258 aa overlap); etc." FT /db_xref="GOA:P95279" FT /db_xref="HSSP:1MJ3" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:P95279" FT /protein_id="CAB06526.1" FT /translation="MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDRP FT KQRNAQTRGMLVELGAAFELAEADDTVRVVILRAAGPAFSAGHDLGSADDIRERSPGPD FT QHPSYRCNGATFGGVESRNRQEWHYYFENTKRWRNLRKITIAQVHGAVLSAGLMLAWCC FT DLIVASEDTVFADVVGTRLGMCGVEYFGHPWEFGPRKTKELLLTGDCIGADEAHALGMV FT SKVFPADELATSTIEFARRIAKVPTMAALLIKESVNQTVDAMGFSAALDGCFKIHQLNH FT AHWGEVTGGKLSYGTVEYGLEDWRAAPQIRPAIKQRP" FT CDS 108681..109790 FT /transl_table=11 FT /locus_tag="Rv1936" FT /product="POSSIBLE MONOOXYGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.-.-.-" FT /note="Rv1936, (MTCY09F9.28c), len: 369 aa. Possible FT monooxygenase (EC 1.-.-.-), similar to LXA2_PHOLU|P23146 FT alkanal monooxygenase alpha chain (362 aa), FASTA scores: FT opt: 196, E(): 6.3e-06, (22.3% identity in 373 aa overlap). FT Also similar to many other Mycobacterium tuberculosis FT hypothetical oxidoreductases and monooxygenases e.g. FT Rv0953c, Rv0791c, Rv0132c, etc." FT /db_xref="GOA:P95278" FT /db_xref="InterPro:IPR016048" FT /db_xref="UniProtKB/TrEMBL:P95278" FT /protein_id="CAB06525.1" FT /translation="MEIGIFLMPAHPPERTLYDATRWDLDVIELADQLGYVEAWVGEHF FT TVPWEPICAPDLLLAQALLRTQQIKLAPGAHLLPYHHPVELAHRVAYFDHLAQGRFMLG FT VGASGIPGDWALYDVDGKNGEHREMTREALEIMLRIWTEDEPWEHRGKYWNANGIAPMF FT EGLMRRHIKPYQKPHPPIGVTGFSAGSETLKLAGERGYIPMSLDLNTEYVATHWDAVEE FT GALRSGRTPDRRDWRLVREVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKFY FT KHNPSVPDDEVTPEYLAENTFVVGSVQTVVDKLEATYDQVGGFGHLLILGFDYSDNPGP FT WKESLRLLAHEVMPRLNARLATKPATAVV" FT CDS 109793..112312 FT /transl_table=11 FT /locus_tag="Rv1937" FT /product="POSSIBLE OXYGENASE" FT /function="UNKNOWN; MAY BE INVOLVED IN ELECTRON TRANSFER." FT /EC_number="1.-.-.-" FT /note="Rv1937, (MTCY09F9.27c), len: 839 aa. Possible FT oxygenase (EC 1.-.-.-), similar in N-terminus to N-terminal FT part (approx. 350 aa) of dioxygenases (including FT ring-hydroxylating dioxygenase electron transfer FT components) and monooxygenases, e.g. AAC34815.1|AF071556 FT anthranilate dioxygenase reductase from Acinetobacter sp. FT (343 aa); AAK52291.1|AY026914|AntC putative anthranilate FT dioxygenase reductase from Pseudomonas putida (340 aa); FT AAF63450.1|AF218267_7|AF218267 benzoate dioxygenase / FT ferredoxin reductase from Pseudomonas putida (336 aa); FT P23101|XYLZ_PSEPU toluate 1,2-dioxygenase electron transfer FT component [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) FT REDUCTASE (EC 1.18.1.3)] from Pseudomonas putida plasmid FT TOL pWW0 (336 aa), FASTA scores: opt: 700, E(): 0, (34.3% FT identity in 335 aa overlap); S23479 probable benzoate FT 1,2-dioxygenase (EC 1.14.12.10) reductase component benC FT from Acinetobacter calcoaceticus (338 aa); FT AAC45294.1|U81594 soluble methane monooxygenase protein C FT from Methylocystis sp. (343 aa); P22868|MEMC_METCA METHANE FT MONOOXYGENASE COMPONENT C from Methylococcus capsulatus FT (348 aa); etc. Also similar in part to Mycobacterium FT tuberculosis hypothetical electron transfer proteins FT Rv3554, Rv3571, etc. Contains PS00197 2Fe-2S ferredoxins, FT iron-sulfur binding region signature." FT /db_xref="GOA:P95277" FT /db_xref="HSSP:1KRH" FT /db_xref="InterPro:IPR017927" FT /db_xref="UniProtKB/TrEMBL:P95277" FT /protein_id="CAB06524.1" FT /translation="MAVRQVTVGYSDGTHKTMPVRCDQTVLDAAEEHGVAIVNECQSGI FT CGTCVATCTAGRYQMGRTEGLSDVERAARKILTCQTFVTSDCRIELQYPVDDNAALLVT FT GDGVVTAVELVSPSTAILRVDTSGMAGALRYRAGQFAQLQVPGTNVWRNYSYAHPADGR FT GECEFIIRLLPDGVMSNYLRDRAQPGDHIALRCSKGSFYLRPIVRPVILVAGGTGLSAI FT LAMAQSLDADVAHPVYLLYGVERTEDLCKLDELTELRRRVGRLEVHVVVARPDPDWDGR FT TGLVTDLLDERMLASGDADVYLCGPVAMVDAARTWLDHNGFHRVGLYYEKFVASGAARR FT RTPARLDYAGVDIAEVCRRGRGTAVVIGGSIAGIAAAKMLSETFDRVIVLEKDGPHRRR FT EGRPGAAQGWHLHHLLTAGQIELERIFPGIVDDMVREGAFKVDMAAQYRIRLGGTWKKP FT GTSDIEIVCAGRPLLEWCVRRRLDDEPRIDFRYESEVADLAFDRANNAIVGVAVDNGDA FT DGGDGLQVVPAEFVVDASGKNTRVPEFLERLGVGAPEAEQDIINCFYSTMQHRVPPERR FT WQDKVMVICYAYRPFEDTYAAQYYTDSSRTILSTSLVAYNCYSPPRTAREFRAFADLMP FT SPVIGENIDGLEPASPIYNFRYPNMLRLRYEKKRNLPRALLAVGDAYTSADPVSGLGMS FT LALKEVREMQALLAKYGAGHRDLPRRYYRAIAKMADTAWFVIREQNLRFDWMKDVDKKR FT PFYFGVLTWYMDRVLELVHDDLDAYREFLAVVHLVKPPSALMRPRIASRVLGKWARTRL FT SGQKTLIARNYENHPIPAEPADQLVNA" FT misc_feature 109913..109939 FT /note="PS00197 2Fe-2S ferredoxins, iron-sulfur binding FT region signature" FT CDS 112324..113394 FT /transl_table=11 FT /gene="ephB" FT /locus_tag="Rv1938" FT /product="PROBABLE EPOXIDE HYDROLASE EPHB (EPOXIDE FT HYDRATASE)" FT /function="THIS ENZYME ACTS ON EPOXIDES (ALKENE OXIDES, FT OXIRANES) AND ARENE OXIDES. PLAYS A ROLE IN XENOBIOTIC FT METABOLISM BY DEGRADING POTENTIAL TOXIC EPOXIDES. ALSO FT DETERMINES STEADY-STATE LEVELS OF PHYSIOLOGICAL MEDIATORS." FT /EC_number="3.3.2.3" FT /note="Rv1938, (MTCY09F9.26c), len: 356 aa. Probable ephB, FT epoxide hydrolase (EC 3.3.2.3) (see citation below), FT similar to many e.g. G1109600 ATSEH (EC 3.3.2.3) (321 aa), FT FASTA scores: opt: 442, E(): 1.2e-21 (33.1% identity in 356 FT aa overlap); etc. Also similar to many other M. FT tuberculosis hypothetical epoxide hydrolases e.g. Rv3617, FT Rv3670, Rv0134, etc." FT /db_xref="GOA:P95276" FT /db_xref="InterPro:IPR000639" FT /db_xref="PDB:2ZJF" FT /db_xref="UniProtKB/TrEMBL:P95276" FT /protein_id="CAB06523.1" FT /translation="MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWRH FT QIPALAGAGYRVVAIDQRGYGRSSKYRVQKAYRIKELVGDVVGVLDSYGAEQAFVVGHD FT WGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVW FT YQDYFAVQDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIR FT AGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWHD FT LADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYRGTHMIADVGHWIQQEAP FT EETNRLLLDFLGGLRP" FT CDS 113391..113906 FT /transl_table=11 FT /locus_tag="Rv1939" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.-.-.-" FT /note="Rv1939, (MTCY09F9.25c), len: 171 aa. Probable FT oxidoreductase (EC 1.-.-.-), similar to FT NP_302637.1|NC_002677 probable oxidoreductase from FT Mycobacterium leprae (162 aa) Also similar to FT NTAB_CHELE|P54990 nitrilotriacetate monooxygenase component FT from Chelatobacter heintzii (322 aa), fasta scores: opt: FT 269, E(): 5.3e-11, (33.1% identity in 151 aa overlap). And FT similar to Mycobacterium tuberculosis probable FT monooxygenase components Rv0246, Rv3567, and to a lesser FT extent, Rv3007c." FT /db_xref="GOA:P95275" FT /db_xref="InterPro:IPR012349" FT /db_xref="UniProtKB/TrEMBL:P95275" FT /protein_id="CAB06522.1" FT /translation="MSCTFDMVPETVDHLDEVGLRRVFGCFPCGVIAVCAMVDDQPVGM FT AASSFTSVSVDPPLVSICVQNCSTTWPKLRDRPRLGVSVLAEGHDAACMSLSRKEGNRF FT AGVFWSELSSGGVVIAGAGAWLDCRPYAEIPAGDHLIALLEICAVRADPETPPLVFHGS FT RFRRLESR" FT CDS 113903..114964 FT /transl_table=11 FT /gene="ribA1" FT /locus_tag="Rv1940" FT /standard_name="ribA" FT /product="Probable Riboflavin biosynthesis protein ribA1 FT (GTP cyclohydrolase II)" FT /function="INVOLVED IN RIBOFLAVIN BIOSYNTHESIS [CATALYTIC FT ACTIVITY : GTP + 3 H(2)O = FORMATE + FT 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE + FT DIPHOSPHATE]" FT /EC_number="3.5.4.25" FT /note="Rv1940, (MTCY09F9.24c), len: 353 aa. Probable ribA1, FT Riboflavin biosynthesis protein (EC 3.5.4.25), similar to FT GCH2_BACSU|P17620 gtp cyclohydrolase ii (EC 3.5.4.25) (398 FT aa), FASTA scores: opt: 682, E(): 0, (37.7% identity in 363 FT aa overlap), also similar to Rv1415|MTCY21B4.33|ribA2 (428 FT aa) (45.4% identity in 368 aa overlap). Note that FT previously known as ribA." FT /db_xref="GOA:Q7D7R0" FT /db_xref="HSSP:1K49" FT /db_xref="InterPro:IPR017945" FT /db_xref="UniProtKB/TrEMBL:Q7D7R0" FT /protein_id="CAE55442.1" FT /translation="MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLV FT AFAVRHTSGYLRVALPGAECERLHLPPMCDRDTTHCVSVDVRGTGTGISASDRAWTIAA FT LASATSVAADFQRPGHVVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIVSPD FT NPVQMAHHAESVEFAVEHGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGF FT RDVYDLGEHLAVIVGAVGAGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQG FT SGVVLYLRPPGPAQACGLFARGDAATDVMPETVTWILRDLGVYAIRLSDDVPGFGLVMF FT GAIREASTLAAAG" FT CDS 114961..115731 FT /transl_table=11 FT /locus_tag="Rv1941" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.-.-.-" FT /note="Rv1941, (MTCY09F9.23c), len: 256 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), similar FT to various dehydrogenases/reductases, generally belonging FT to SDR family, e.g. NP_299015.1|NC_002488 FT 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from FT Xylella fastidiosa (255 aa); NP_250340.1|NC_002516 probable FT short-chain dehydrogenase from Pseudomonas aeruginosa (253 FT aa); NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa) FT (has its N-terminus longter); P50197|LINC_PSEPA FT 2,5-dichloro-2,5-cyclohexadiene-1,4-dehydrogenase from FT Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 FT aa), FASTA scores: opt: 529, E(): 5.7e-25, (40.6% identity FT in 251 aa overlap); etc. Contains PS00061 Short-chain FT alcohol dehydrogenase family signature. BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P95273" FT /db_xref="InterPro:IPR016040" FT /db_xref="PDB:3GVC" FT /db_xref="UniProtKB/TrEMBL:P95273" FT /protein_id="CAB06520.1" FT /translation="MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDAA FT DAAATKIGCGAAACRVDVSDEQQIIAMVDACVAAFGGVDKLVANAGVVHLASLIDTTVE FT DFDRVIAINLRGAWLCTKHAAPRMIERGGGAIVNLSSLAGQVAVGGTGAYGMSKAGIIQ FT LSRITAAELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGRMAAP FT EEMAGIVVFLLSDDASMITGTTQIADGGTIAALW" FT misc_feature 115381..115467 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS complement(115941..116270) FT /transl_table=11 FT /locus_tag="Rv1942c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1942c, (MTCY09F9.22), len: 109 aa. Conserved FT hypothetical protein, shows some similarity to FT Q10867|MTCY39.28|Rv1991 hypothetical 12.3 kDa protein (114 FT aa), FASTA scores: opt: 117, E(): 0.021, (24. 5% identity FT in 110 aa overlap) also P33645|CHPA_ECOLI pemk-like protein FT 1 (mazf protein) from Escherichia coli (111 aa), FASTA FT scores: opt: 104, E(): 0.18, (29.1% identity in 110 aa FT overlap). Also similar to Mycobacterium tuberculosis FT Rv0659c (102 aa) (32.7% identity in 101 aa overlap); FT Rv1102c (33.3% identity in 93 aa overlap) and Rv1495." FT /db_xref="GOA:P95272" FT /db_xref="HSSP:1UB4" FT /db_xref="InterPro:IPR003477" FT /db_xref="UniProtKB/TrEMBL:P95272" FT /protein_id="CAB06519.1" FT /translation="MTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTT FT TIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVAVLVNRLGRLADIRMRAICTALEVA FT VDCSR" FT CDS complement(116267..116644) FT /transl_table=11 FT /locus_tag="Rv1943c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1943c, (MTCY09F9.21), len: 125 aa. Conserved FT hypothetical protein, showing some similarity with FT Rv1946c|MTCY09F9.18|lppG possible conserved lipoprotein FT from Mycobacterium tuberculosis (150 aa), FASTA score: FT (71.4% identity in 28 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P95271" FT /protein_id="CAB06518.1" FT /translation="MKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHS FT SGMNRIRLSTTVDAALLTSARDMRAGITDAALIDEALAALLARHRSAEVDASYAAYDKH FT PVDEPDEWGDLASWRRAAGDS" FT CDS complement(116641..117231) FT /transl_table=11 FT /locus_tag="Rv1944c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1944c, (MTCY09F9.20), len: 196 aa. Conserved FT hypothetical protein, similar to C-terminal part of FT SCE20.29|AL136058|CAB65585.1 hypothetical protein from FT Streptomyces coelicolor (338 aa), BLASTP scores, Identities FT = 37/131 (28%), Positives = 51/131 (38%)." FT /db_xref="InterPro:IPR004027" FT /db_xref="UniProtKB/TrEMBL:P95270" FT /protein_id="CAB06517.1" FT /translation="MISDTEDFAHGDKAAPPRLRASYAACGGDAAGCWTMSDNGASRVP FT PVDETPAAESAEPITAVSLAWLPAGDYERALDLWPDFAGSDLVTGPDGPVAHPLYCRRM FT QQKLVEFAEAGFPGLAVAAIRVAPFAAWCAEQGQEPDSPEARAEYAAYLTAHGDHDVMA FT WPPGRNQQCWCGSGHKYKKCCAAASFIDTEPAP" FT CDS 117286..118650 FT /transl_table=11 FT /locus_tag="Rv1945" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1945, (MTCY09F9.19c), len: 454 aa. Member of FT Mycobacterium tuberculosis REP13E12 repeat family. Similar FT to several others, best with Rv1148c|Z95584|MTCI65.15 (482 FT aa), FASTA score: opt: 2954, E(): 0, (97.1% identity in 454 FT aa overlap). Contains possible helix-turn-helix motif at aa FT 74-95 (+2.90 SD)." FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/Swiss-Prot:P95269" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06516.1" FT /translation="MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEV FT ERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRA FT LTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATS FT RRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATI FT EAVLAKLAAPGACNPDDQTPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLLASGEL FT GQHRGLPVTVVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASNAHHYLALFDGAKPL FT ALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLAC FT GPDNRLVEKGWKTRKNAKGDTEWLPPAHLDHGQPRINRYHHPEKILCEPDDDEPH" FT repeat_region 117286..118647 FT /label=REP-7 FT /rpt_type=DIRECT FT /note="REP-7, len: 1362 bp. REP09F9, member of the REP13E12 FT family." FT CDS complement(118805..119257) FT /transl_table=11 FT /gene="lppG" FT /locus_tag="Rv1946c" FT /product="POSSIBLE LIPOPROTEIN" FT /function="UNKNOWN" FT /note="Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG, FT conserved lipoprotein, showing some similarity to FT Rv1943c|MTCY09F9.21 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% FT identity in 28 aa overlap). Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site." FT /db_xref="UniProtKB/TrEMBL:P95268" FT /protein_id="CAB06515.1" FT /translation="MIRGSAVSGLLMPSVNGGTAGSVACVQCLFLPKVAVDLINLSGIQ FT CFARIEHVAHAQAHPFVVLVGKPAQHGARIGAVAGAILTGDVIVSHDGELYRAVTALRQ FT NGPRPHASRRLHAPALCSARSRRGHLRPSCWLPPPRFAGRQSLVAR" FT misc_feature complement(119183..119215) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 119321..119722 FT /transl_table=11 FT /locus_tag="Rv1947" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1947, (MTCY09F9.17c), len: 133 aa. Hypothetical FT unknown protein" FT /db_xref="UniProtKB/TrEMBL:P95267" FT /protein_id="CAB06514.1" FT /translation="MDRYNDQASGRALIEIRLCNERATPMPIPIGLWMFQTKLHVNAGG FT ADVFLPVCDVLEQDLAERDEEVRQLNLQYRNRLEYAIGRTCSAAWSVNGSRRPSAVWTT FT WLPVAETPHTRARSVENALLSMDSRGGVT" FT CDS complement(120011..120361) FT /transl_table=11 FT /locus_tag="Rv1948c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1948c, (MTCY09F9.16), len: 116 aa. Hypothetical FT unknown protein" FT /db_xref="UniProtKB/TrEMBL:P95266" FT /protein_id="CAB06513.1" FT /translation="MTVFGIKPDNYFGDVVLAAADRDGLRIFQYAVRSAHESGQATFDI FT DGVQQRIVRESGTADMELGSQTVVWRFDDTKLVEILDKLSPLIDGEGPGHQYIDDLNSP FT APTLMISVDEYA" FT CDS complement(120372..>121331) FT /transl_table=11 FT /locus_tag="Rv1949c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1949c, (MTCY09F9.15), len: 319 aa. Conserved FT hypothetical protein, partial ORF. Rv1949c and FT Rv1950c|MTCY09F9.14 are similar but frameshifted with FT respect to Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kd FT protein (323 aa), FASTA scores: opt: 459, E(): 2.8e-16, FT (54.8% identity in 157 aa overlap). Cosmid sequence appears FT to be correct, genomic sequence is also frameshifted in FT Mycobacterium bovis strain AF2122/97. Similar to FT Mycobacterium tuberculosis hypothetical proteins: Rv2542, FT Rv2077c, Rv2797c, Rv0963c, etc." FT /db_xref="UniProtKB/TrEMBL:P95265" FT /protein_id="CAB06512.1" FT /translation="WLRQRTGADLQIVSGIAEHLRQASGLAREGAGTIGAAQRRVIYAV FT QDAHNAGFNVEEDLSVTDTRTSRTFAEQAARQAQAQALAGDIRQRATQLIGVEHEVAAK FT IATATAPLNTVGFHEPPIAPSLPTPVPHNEKPQIHAVDRSWKQDPPSPMPGDPKDMTAV FT QARAAWDAVNADIARYNARCGRTFVLPNEQAAYDACIADKGSLFERQAAIRARLGELGV FT PVEGEPPPAPDPAGPQPNEGLPPPGVSPPAESNLTVGPPSRPIQQARGGESLWDENGGE FT WRYFPGDNYRYPHWDYNPHDSPTARWQNIPIGDLPTHK" FT CDS complement(121295..121486) FT /transl_table=11 FT /locus_tag="Rv1950c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1950c, (MTCY09F9.14), len: 63 aa. Conserved FT hypothetical protein, partial ORF. Highly similar to FT N-terminus of Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 FT kDa protein (323 aa), FASTA scores: opt: 280, E(): 1.2 FT e-16, (71.7% identity in 53 aa overlap) but homology FT continues in different frame ie MTCY09F9.15, cosmid FT sequence appears to be correct, genomic sequence is also FT frameshifted in Mycobacterium bovis strain AF2122/97." FT /db_xref="UniProtKB/TrEMBL:P95264" FT /protein_id="CAB06511.1" FT /translation="MLPTLSHIHAWDTEHLIEAAYYWTKVADQWEDVFLEMRNRSHFIA FT WEGAGGDGCDSEPALTYR" FT CDS complement(121487..121783) FT /transl_table=11 FT /locus_tag="Rv1951c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1951c, (MTCY09F9.13), len: 98 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical protein Rv2541 (135 aa) (40.9% identity in 88 FT aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P95263" FT /protein_id="CAB06510.1" FT /translation="MKAGELRVNIQQVAATASQWSGRSTELSVLAPPPLGQPFQPTTAA FT VGGAHAAVGLAVAAFTARTHATASAVEAAAAEYANNEAAAAAEMAAVPQTRLV" FT CDS 122023..122238 FT /transl_table=11 FT /locus_tag="Rv1952" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1952, (MTCY09F9.12c), len: 71 aa. Conserved FT hypothetical protein. Some similarity to P55510|Y4JJ_RHISN FT PUTATIVE PLASMID STABILITY PROTEIN (85 aa), FASTA scores: FT opt: 127, E(): 0.00096, (42.5% identity in 73 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P95262" FT /protein_id="CAB06509.1" FT /translation="MIRNLPEGTKAALRVRAARHHHSVEAEARAILTAGLLGEEVPMPV FT LLAADSGHDIDFEPERLGLIARTPQL" FT CDS 122235..122546 FT /transl_table=11 FT /locus_tag="Rv1953" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1953, (MTCY09F9.11c), len: 103 aa. Conserved FT hypothetical protein. Some similarity to O33827 PLASMID FT STABILITY-LIKE PROTEIN from Thiobacillus ferrooxidans (143 FT aa), FASTA scores: opt: 170, E(): 3.5e-06, (45.3% identity FT in 75 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:P95261" FT /protein_id="CAB06508.1" FT /translation="MTYVLDTNVVSALRVPGRHPAVAAWADSVQVAEQFVVAITLAEIE FT RGVIAKERTDPTQSEHLRRWFDDKVLRIFVFARRGTNLIMQPLAGHIGYSLYSGISWF" FT CDS complement(122520..123041) FT /transl_table=11 FT /locus_tag="Rv1954c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1954c, (MTCY09F9.10), len: 173 aa. Hypothetical FT unknown protein, end overlaps next ORF upstream, Rv1955 FT (MTCY09F9.09c)." FT /db_xref="UniProtKB/Swiss-Prot:P95260" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06507.1" FT /translation="MAAGSGGGTVGLVLPRVASLSGLDGAPTVPEGSDKALMHLGDPPR FT RCDTHPDGTSSAAAALVLRRIDVHPLLTGLGRGRQTVSLRNGHLVATANRAILSRRRSR FT LTRGRSFTSHLITSCPRLDDHQHRHPTRCRAEHAGCTVATCIPNAHDPAPGHQTPRWGP FT FRLKPAYTRI" FT CDS 122881..123393 FT /transl_table=11 FT /locus_tag="Rv1955" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1955, (MTCY09F9.09c), len: 170 aa. Hypothetical FT unknown protein, start overlaps another ORF, Rv1954c FT (MTCY09F9.10)." FT /db_xref="InterPro:IPR009241" FT /db_xref="UniProtKB/TrEMBL:P95259" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06506.1" FT /translation="MPSGWVSHRLGGSPKCISALSLPSGTVGAPSKPDNDATRGRTRPT FT VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKP FT IRGDILELRWHEANNHFRVLFFRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRA FT FGDTPPI" FT CDS 123435..123884 FT /transl_table=11 FT /locus_tag="Rv1956" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv1956, (MTCY09F9.08c), len: 149 aa. Possible FT transcriptional regulatory protein, contains probable FT helix-turn-helix motif at aa 52-73 (+4.78 SD)." FT /db_xref="GOA:P95258" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/TrEMBL:P95258" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06505.1" FT /translation="MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIAL FT RKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLSTLQRYARALDARLRLVLEVPTLRE FT VPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA" FT CDS 123881..124426 FT /transl_table=11 FT /locus_tag="Rv1957" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1957, (MTCY09F9.07c), len: 181 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P95257" FT /protein_id="CAB06536.1" FT /translation="MTDRTDADDLDLQRVGARLAARAQIRDIRLLRTQAAVHRAPKPAQ FT GLTYDLEFEPAVDADPATISAFVVRISCHLRIQNQAADDDVKEGDTKDETQDVATADFE FT FAALFDYHLQEGEDDPTEEELTAYAATTGRFALYPYIREYVYDLTGRLALPPLTLEILS FT RPMPVSPGAQWPATRGTP" FT CDS complement(124315..124929) FT /transl_table=11 FT /locus_tag="Rv1958c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1958c, (MTCY09F9.06), len: 204 aa. Hypothetical FT unknown protein, questionable ORF" FT /db_xref="UniProtKB/TrEMBL:P95256" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06535.1" FT /translation="MIPTPSIGAVINAKISHRACRTFPRPTDIHPRRYLPRKHGGTNPR FT RLSMNPGGMRIRCRRGDKSRKLLSRSQVQPLVGRPAKIPSPAANAPPSRARTASPVFEN FT LELRAAAGLAFGFRLRPFGGTAADSPPVAAQDLDPCRWADSPALHLAVGVETMVVGQLD FT SPSFGQGVPLVAGHWAPGETGIGRDNISRVNGGSARRPVRS" FT CDS complement(124978..125274) FT /transl_table=11 FT /locus_tag="Rv1959c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1959c, (MTCY09F9.05), len: 98 aa. Conserved FT hypothetical protein, similar to other hypothetical plasmid FT proteins e.g. AL117189|YPCD1.08 from Yersinia pestis (99 FT aa), FASTA scores: opt: 162, E(): 7.3e-05, (33.0% identity FT in 91 aa overlap); also some similarity to E145339 FT hypothetical protein (103 aa), FASTA scores: opt: 142, E(): FT 0.0003, (33.0% identity in 91 aa overlap)." FT /db_xref="InterPro:IPR007712" FT /db_xref="UniProtKB/TrEMBL:P95255" FT /protein_id="CAB06534.1" FT /translation="MSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRA FT AANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEGTIDVVRVLHQRMDVDRNL" FT CDS complement(125271..125522) FT /transl_table=11 FT /locus_tag="Rv1960c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1960c, (MTCY09F9.04), len: 83 aa. Conserved FT hypothetical protein, similar to FT O85269|AF102990|AF102990_51 hypothetical protein of FT Yersinia enterocolitica (80 aa), FASTA scores: opt: 149, FT E(): 0.00037, (42 .1% identity in 57 aa overlap)." FT /db_xref="GOA:P67298" FT /db_xref="InterPro:IPR005360" FT /db_xref="UniProtKB/Swiss-Prot:P67298" FT /protein_id="CAB06533.1" FT /translation="MGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRET FT QLRALREALEAGERSGSSTPFDFDGFLGRKRADASRGR" FT CDS 125509..126003 FT /transl_table=11 FT /locus_tag="Rv1961" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1961, MTCY09F9.03c, len: 164 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P95253" FT /protein_id="CAB06532.1" FT /translation="MFLPTNAQYQLLVVGVSPWDTPSPSGRISWGSAWPHQARRAQTCQ FT RVRRHWMIDTTEAAYRLTYQPDGTSITVRENLVDILARELLGPIRGPQEVLPFSPRSQY FT LVGHLAPVKLTGAALIDDNAVQARANAEALAEGGGVPAYAADETTPTPTTTPKTAHPSR FT A" FT CDS complement(126163..126570) FT /transl_table=11 FT /locus_tag="Rv1962c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1962c, (MTCY09F9.02), len: 135 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical proteins Rv3408|MTCY78.20c (133 aa) (36.2% FT identity in 138 aa overlap); and Rv3384c (130 aa) (43.1% FT identity in 130 aa overlap)" FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:P95252" FT /protein_id="CAB06531.1" FT /translation="MIYLETSALVKLIRIEVESDALADWLDDRTELRWITSALTEVELS FT RAIRAVSPEGLPAVPSVLARLDRFEIDAVIRSTAAAYPNPALRSLDAIHLATAQTAGSV FT APLTALVTYDNRLKEAAEALSLAVVAPGQAR" FT CDS complement(126879..128099) FT /transl_table=11 FT /gene="mce3R" FT /locus_tag="Rv1963c" FT /product="PROBABLE TRANSCRIPTIONAL REPRESSOR (PROBABLY FT TETR-FAMILY) MCE3R" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM; FT REPRESSION OF THE MCE3 OPERON. COULD ALSO HAVE A REGULATORY FT ACTION ON THE MCE2 OPERON." FT /note="Rv1963c, (MTV051.01c-MTCY09F9.01), len: 406 aa. FT Probable mce3R, negative transcriptional regulatory FT protein, tetR family (see citation below); similar to FT several transcriptional regulator e.g. AL049485|SC6A5.30 FT Streptomyces coelicolor cosmid 6 A (404 aa), FASTA scores: FT opt: 319, E(): 6.4e-13, (29.5% identity in 373 aa overlap); FT and Z84498|MTCY9F9_1 (259 aa), FASTA scores: opt: 208, E(): FT 1.6e-07, (100.0% identity in 32 aa overlap). Contains FT probable helix-turn-helix at aa 36-57 (+4.23 SD) and two FT tet-R family signatures." FT /db_xref="GOA:P95251" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:P95251" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06537.1" FT /translation="MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAG FT VTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLEDLIAAAVA FT SRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSS FT TLTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYET FT LLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRCLEC FT IRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREA FT VWIDLIGKLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLALAILTSG FT AGNLLRA" FT CDS 128997..129794 FT /transl_table=11 FT /gene="yrbE3A" FT /locus_tag="Rv1964" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE3A" FT /function="UNKNOWN" FT /note="Rv1964, (MTV051.02), len: 265 aa. yrbE3A, FT hypothetical unknown integral membrane protein, part of FT mce3 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa), FT O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa), FT Rv3501c|MTV023.08c|yrbE4A (254 aa), etc. Also highly FT similar to conserved hypothetical integral membrane FT proteins of yrbEA type, e.g. AAD24544.1|AF116213|YrbE1A FT from Mycobacterium leprae (112 aa); P45392|YRBE_ECOLI from FT Escherichia coli (260 aa), FASTA scores: opt: 893, E(): 0, FT (51.4% identity in 253 aa overlap); etc. TBparse score is FT 0.889. The transcription of this CDS seems negatively FT regulated by the product of Rv1963c|mce3R (see Santangelo FT et al., 2002)." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:O53965" FT /protein_id="CAA17837.1" FT /translation="MVIVADKAAGRVADPVLRPVGALGDFFAMTLDTSVCMFKPPFAWR FT EYLLQCWFVARVSTLPGVLMTIPWAVISGFLFNVLLTDIGAADFSGTGCAIFTVNQSAP FT IVTVLVVAGAGATAMCADLGARTIREELDALRVMGINPIQALAAPRVLAATTVSLALNS FT VVTATGLIGAFFCSVFLMHVSAGAWVTGLTTLTHTVDVVISMIKATLFGLMAGLIACYK FT GMSVGGGPAGVGRAVNETVVFAFIVLFVINIVVTAVGIPFMVS" FT CDS 129804..130619 FT /transl_table=11 FT /gene="yrbE3B" FT /locus_tag="Rv1965" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE3B" FT /function="UNKNOWN" FT /note="Rv1965, (MTV051.03), len: 271 aa. yrbE4B, FT hypothetical unknown integral membrane protein, part of FT mce3 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa), FASTA FT scores: opt: 937, E(): 0, (54.3% identity in 254 aa FT overlap); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); etc. FT Also highly similar to conserved hypothetical integral FT membrane proteins of the yrbEB type, e.g. FT AAD24545.1|AF116213|YrbE1B from Mycobacterium leprae (106 FT aa); P45392|YRBE_ECOLI HYPOTHETICAL 27.9 kDa PROTEIN from FT Escherichia coli (260 aa), FASTA scores: opt: 218, E(): FT 1.2e-07, (24.1% identity in 245 aa overlap); etc. TBparse FT score is 0.881. The transcription of this CDS seems FT negatively regulated by the product of Rv1963c|mce3R (see FT Santangelo et al., 2002)." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:O53966" FT /protein_id="CAA17838.1" FT /translation="MTAAKALVSEWNRMGSQMRFFVGTLAGIPDALMHYRGELLRVIAQ FT MGLGTGVLAVIGGTVAIVGFLAMTTGAIVAVQGYNQFASVGVEALTGFASAFFNTREIQ FT PGTVMVALAATVGAGTTAALGAMRINEEIDALEVIGIRSISYLASTRVLAGVVVAVPLF FT CVGLMTAYLAARVGTTAIYGQGSGVYDHYFNTFLRPTDVLWSSVEVVVVALMIMLVCTY FT YGYAAHGGPAGVGEAVGRAVRASMVVASIAILVMTLAIYGQSPNFHLAT" FT CDS 130624..131901 FT /transl_table=11 FT /gene="mce3A" FT /locus_tag="Rv1966" FT /standard_name="mce3" FT /product="MCE-FAMILY PROTEIN MCE3A" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv1966, (MTV051.04), len: 425 aa. mce3A; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A FT (454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); FT etc. Also highly similar to others e.g. FT AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry FT protein from Mycobacterium bovis BCG (454 aa); FT NP_302656.1|NC_002677 putative cell invasion protein from FT Mycobacterium leprae (441 aa); CAC12798.1|AL445327 putative FT secreted protein from Streptomyces coelicolor (418 aa); FT etc. Contains a possible N-terminal signal sequence or FT membrane anchor. TBparse score is 0.897. Note that FT previously known as mce3. The transcription of this CDS FT seems negatively regulated by the product of Rv1963c|mce3R FT (see Santangelo et al., 2002)." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:Q7D7P0" FT /protein_id="CAE55443.1" FT /translation="MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVT FT LAADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEWAQNGASLRLEIDPDQIRYIPANVEA FT QISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEINTVFENVVDLLNMIDPLK FT LNAVLTAVADAVRGQGERIGQATTDLNEVLEALNARGDTIGGNWRSLKNFTDTYDAAAQ FT DILTILNAASTTSATVVNHSTQLDALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTT FT SLLFKYNPEYTCFLQGAKWYLDNGGYAAWGGADGRTLQLDVALLFGNDPYVYPDNLPVV FT AAKGGPGGRPGCGPLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVTRA FT VPEPPSIRQCIPGPAIGPNPAAGEQP" FT CDS 131898..132926 FT /transl_table=11 FT /gene="mce3B" FT /locus_tag="Rv1967" FT /product="MCE-FAMILY PROTEIN MCE3B" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv1967, (MTV051.05), len: 342 aa. mce3B; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 FT aa); O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); etc. Also FT similar to others e.g. NP_302657.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (346 aa); FT CAC12797.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (354 aa); etc. Contains a possible FT N-terminal signal sequence or membrane anchor. TBparse FT score is 0.872. The transcription of this CDS seems FT negatively regulated by the product of Rv1963c|mce3R (see FT Santangelo et al., 2002)." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O53968" FT /protein_id="CAA17840.1" FT /translation="MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDGKTYYAEF FT ANVSNLRTGKLVRIAGVEVGKVTRISINPDATVRVQFTADNSVTLTRGTRAVIRYDNLF FT GDRYLALEEGAGGLAVLRPGHTIPLARTQPALDLDALIGGFKPLFRALNPEQVNALSEQ FT LLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLIGQVITNLNVVLGSLGAHTDRLDQAVT FT SLSALIHRLAQRKTDISNAVAYTNAAAGSVADLLSQARAPLAKVVRETDRVAGIAAADH FT DYLDNLLNTLPDKYQALVRQGMYGDFFAFYLCDVVLKVNGKGGQPVYIKLAGQDSGRCA FT PK" FT CDS 132923..134155 FT /transl_table=11 FT /gene="mce3C" FT /locus_tag="Rv1968" FT /product="MCE-FAMILY PROTEIN MCE3C" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv1968, (MTV051.06), len: 410 aa. mce3C; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 FT aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); etc. Also FT similar to others e.g. CAC12796.1|AL445327 putative FT secreted protein from Streptomyces coelicolor (351 aa); FT NP_302658.1|NC_002677 putative secreted protein from FT Mycobacterium leprae (519 aa); etc. Contains a possible FT N-terminal signal sequence or membrane anchor. TBparse FT score is 0.875. The transcription of this CDS seems FT negatively regulated by the product of Rv1963c|mce3R (see FT Santangelo et al., 2002)." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:O53969" FT /protein_id="CAA17841.1" FT /translation="MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAY FT FADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEVAIKTKGLL FT GSKFLDVTPRGDGRLDSPIPIERTTSPYQLPDALGDLAATISGLHTERLSESLATLAQT FT FADTPAHFRNAIHGVARLAQTLDERDNQLRSLLANAAKATGVLANRTDQIVGLVRDTNV FT VLAQLRTQSAALDRIWANISAVAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVR FT QAIPLINTYVMSLGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQL FT TDPPTGQPGTPPLPMPYPRTGQGGEPRLTLPDAITGNPGDPRYPYRPEPPAPPPGGPPP FT GPPAQQPGDQP" FT CDS 134152..135423 FT /transl_table=11 FT /gene="mce3D" FT /locus_tag="Rv1969" FT /product="MCE-FAMILY PROTEIN MCE3D" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv1969, (MTV051.07), len: 423 aa. mce3D; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 FT aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); etc. Also FT highly similar to others e.g. NP_302659.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (531 FT aa); CAC12795.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (337 aa); etc. Contains a possible FT N-terminal signal sequence or membrane anchor. TBparse FT score is 0.872. The transcription of this CDS seems FT negatively regulated by the product of Rv1963c|mce3R (see FT Santangelo et al., 2002)." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O53970" FT /protein_id="CAA17842.1" FT /translation="MTTKLRRARSVLATALVLVAGVILAMRTADAAARTTVVAYFDNSN FT GVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPADAAAAILSPQLVTGRAI FT QLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRAQLQRLTALLQPTRPGGVSTLGALIN FT TAADNLRGQGATIRDTIIKLSQAISALGDHSKDIFSTVTNLSTLVTALHDSADLLERLN FT HNLAAVTSLLADGPDKIGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVDS FT LDDIKQTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCGAIQAASRLGGEQ FT AAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWLRPDYVAPVADTPPD FT PAAAVTVDPATGLRGMMMPPGGGS" FT CDS 135420..136553 FT /transl_table=11 FT /gene="lprM" FT /locus_tag="Rv1970" FT /standard_name="mce3E" FT /product="POSSIBLE MCE-FAMILY LIPOPROTEIN LPRM (MCE-FAMILY FT LIPOPROTEIN MCE3E)" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv1970, (MTV051.08), len: 377 aa. Possible lprM FT (alternate gene name: mce3E), lipoprotein which belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E FT (390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); FT etc. Also highly similar to others e.g. FT NP_302660.1|NC_002677 putative lipoprotein from FT Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative FT secreted protein from Streptomyces coelicolor (413 aa); FT etc. Contains possible N-terminal signal sequence or FT membrane anchor and PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. TBparse score is 0.880. FT The transcription of this CDS seems negatively regulated by FT the product of Rv1963c|mce3R (see Santangelo et al., FT 2002)." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O53971" FT /protein_id="CAA17843.1" FT /translation="MRIGLTLVMIAAVVASCGWRGLNSLPLPGTQGNGPGSFAVQAQLP FT DVNNIQPNSRVRVADVTVGHVTKIERQGWHALVTMRLDGDVDLPANATAKIGTTSLLGS FT YHIELAPPKGEARQGKLRDGSLIALSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEA FT LSTAFAGREHDLRGLIGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALA FT TIPDALAVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLANSG FT PALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLLTGTRWECHLTQL FT ELQWGRTIGQFPSPCTAGYRGTPGNPLTIAYRWDQGP" FT misc_feature 135438..135470 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 136554..137867 FT /transl_table=11 FT /gene="mce3F" FT /locus_tag="Rv1971" FT /product="MCE-FAMILY PROTEIN MCE3F" FT /function="UNKNOWN, BUT THOUGHT INVOLVED IN HOST CELL FT INVASION." FT /note="Rv1971, (MTV051.09), len: 437 aa. mce3F; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), similar to Mycobacterium FT tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 FT aa), O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); etc. Also FT highly similar to others e.g. NP_302661.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (516 FT aa); CAC12793.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (433 aa); etc. Contains a possible FT N-terminal signal sequence or membrane anchor. TBparse FT score is 0.881. The transcription of this CDS seems FT negatively regulated by the product of Rv1963c|mce3R (see FT Santangelo et al., 2002)." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:O53972" FT /protein_id="CAA17844.1" FT /translation="MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTV FT TMELVEAGGLYRTGNVTYRGFEVGRVAAVRLTDTGVQAVLALKSGIDIPSDLKAEVHSH FT TAIGETYVELLPRNAASPPLKNGDVIALADTSVPPDINDLLSAANTALEAIPHENLQTV FT IDESYTAVAGLGLELSRLIKGSAELAIDARANLDPLVALIDRAGPVLDSQTHTSDAIAA FT WAAQLAAVTGQLQTHDSAVGDLIDRGGPALGETRQLLERLQPTVPILLANLVSVGQVAL FT TYHNDIEQLLVVFPMAIAAEQAGILANLNTKQAYRGQYLSFNLNLNLPPPCTTGFLPAQ FT QRRIPTFEDYPDRPAGDLYCRVPQDSPFNVRGARNIPCETVPGKRAPTVKLCESDAPYL FT PLNDGYNWKGDPNATVPGLGSGQDIPQTWQTMLLPPGS" FT CDS 137889..138464 FT /transl_table=11 FT /locus_tag="Rv1972" FT /product="PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv1972, (MTV051.10), len: 191 aa. Probable conserved FT Mce-associated membrane protein. Probably part of mce3 FT operon. Similar to several Mycobacterium tuberculosis FT proteins e.g. Rv1363c|Z75555|MTCY02B10.27C (261 aa), FASTA FT scores: opt: 342, E(): 1.2e-15, (31.8% identity in 195 aa FT overlap); Rv1362c, Rv0177 (near Mce operon 1), etc. Has FT hydrophobic stretch at aa 20-40. TBparse score is 0.896." FT /db_xref="UniProtKB/TrEMBL:O53973" FT /protein_id="CAA17845.1" FT /translation="MSVAVDSDAEDDAVSEIAEAAGVSPAPAKPSMSAPRRMLLFGLVV FT VVALAVLLCCWGFRVQRARHAQDQRGHFLQAARQCALNLTTIDWRNAEADVRRILDGAT FT GEFYNDFAQRSQPFVEVLRHAKASTVGTITEAGLQTQTADTAQALVAVSVQTSNAGEAD FT PVPRAWRMRITVQRVGDRVKVSDVGFVP" FT CDS 138461..138943 FT /transl_table=11 FT /locus_tag="Rv1973" FT /product="POSSIBLE CONSERVED MCE ASSOCIATED MEMBRANE FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv1973, (MTV051.11), len: 160 aa. Possible conserved FT Mce-associated membrane protein. Probably part of mce3 FT operon. Similar to several other proteins from FT Mycobacterium tuberculosis e.g. FT Rv1362c|Z75555|MTCY02B10.26C (220 aa), FASTA scores: opt: FT 378, E(): 2.8e-19, (50.0% identity in 128 aa overlap); FT Rv1363c; Rv0177 (near Mce operon 1); etc. Contains possible FT N-terminal signal sequence or membrane anchor. TBparse FT score is 0.863." FT /db_xref="UniProtKB/TrEMBL:O53974" FT /protein_id="CAA17846.1" FT /translation="MSWSRVIAYGLLPGLALALTCGAGLLKWQDGAVRDAAVARAESVR FT AATDGTTALLSYRPDTVQHDLESARSRLTGTFLDAYTQLTHDVVIPGAQQKQISAVATV FT AAAASVSTSADRAVVLLFVNQTITVGKDAPTTAASSVRVTLDNINGRWLISQFEPI" FT CDS 138956..139333 FT /transl_table=11 FT /locus_tag="Rv1974" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1974, (MTV051.12), len: 125 aa. Probable conserved FT membrane protein, weakly similar to other Mycobacterium FT tuberculosis proteins e.g. Rv1271c|Z77137|MTCY50.11 (113 FT aa), FASTA scores: opt: 98, E(): 1.4, (24.5% identity in FT 110 aa overlap); Rv1804c; Rv1690. Has possible signal FT peptide or transmembrane stretch from aa 12-30. TBparse FT score is 0.915." FT /db_xref="UniProtKB/TrEMBL:O53975" FT /protein_id="CAA17847.1" FT /translation="MQRQSLMPQQTLAAGVFVGALLCGVVTAAVPPHARADVVAYLVNV FT TVRPGYNFANADAALSYGHGLCEKVSRGRPYAQIIADVKADFDTRDQYQASYLLSQAVN FT ELCPALIWQLRNSAVDNRRSG" FT CDS 139349..140014 FT /transl_table=11 FT /locus_tag="Rv1975" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1975, (MTV051.13), len: 221 aa. Conserved FT hypothetical protein, showing some similarity to AJ251435 FT hypothetical protein from Mycobacterium avium subsp. FT paratuberculosis (193 aa). TBparse score is 0.919." FT /db_xref="UniProtKB/TrEMBL:O53976" FT /protein_id="CAA17848.1" FT /translation="MSRRASATCALSATTAVAIMAAPAARADDKRLNDGVVANVYTVQR FT QAGCTNDVTINPQLQLAAQWHTLDLLNNRHLNDDTGSDGSTPQDRAHAAGFRGKVAETV FT AINPAVAISGIELINQWYYNPAFFAIMSDCANTQIGVWSENSPDRTVVVAVYGQPDRPS FT AMPPRGAVTGPPSPVAAQENVPIDPSPDYDASDEIEYGINWLPWILRGVYPPPAMPPQ" FT CDS complement(140141..140548) FT /transl_table=11 FT /locus_tag="Rv1976c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1976c, (MTV051.14), len: 135 aa. Conserved FT hypothetical protein, similar to SC1C3.03c|AL023702 FT hypothetical protein from Streptomyces coelicolor (125 aa), FT FASTA score: opt: 223, E(): 3.3e-08, (39.6% identity in 111 FT aa overlap). TBparse score is 0.891." FT /db_xref="UniProtKB/TrEMBL:O53977" FT /protein_id="CAA17849.1" FT /translation="MRWIVDGMNVIGSRPDGWWRDRHRAMVMLVERLEGWAITKARGDD FT VTVVFERPPSTAIPSSVVEVAHAPKAAANSADDEIVRLVRSGAQPQEIRVVTSDKALTD FT RVRDLGAAVYPAERFRDLIDPRGSNAARRTQ" FT CDS 141051..142097 FT /transl_table=11 FT /locus_tag="Rv1977" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1977, (MTV051.15), len: 348 aa. Conserved FT hypothetical protein, similar to SCC123.20|AL136518 FT hypothetical protein from Streptomyces coelicolor (402 aa), FT BLASTP scores: Score = 311 bits (789), Expect = 5e-84 FT Identities = 156/316 ( 49%), Positives = 212/316 (66%); and FT PCC6803|D90907_31 Synechocystis sp. (303 aa), FASTA scores: FT opt: 533, E(): 4.7e- 29, (38.5% identity in 275 aa FT overlap). Contains PS00142 Neutral zinc metallopeptidases, FT zinc-binding region signature. TBparse score is 0.898." FT /db_xref="GOA:O53978" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:O53978" FT /protein_id="CAA17850.1" FT /translation="MSQTPATTRKTFPEISSRAWEHPADRTALSALRRLKGFDQILKLM FT SGMLRERQHRLLYLASAARVGPRQFADLDALLDECVDVLDASAKPELYVMQSPIADAFT FT IGMGKPFTVITSGLYDLVTHDEMRFVMGHELGHALSGHAVYRTMMMHLLRLARSFGVLP FT VGGWALRAIVAALLEWQRKSELSGDRAGLLCAQDLDTALRVEMKLAGGCRLDKLDSEAF FT LAQAREYETSGDMRDGVLKLLNLELQTHPFSVLRAAALTHWVDTGGYAKVIAGEYPRRA FT DDGNAKFADDLGAAARYYRDGFDQSNDPLIKGIRDGFGGIVEGVGRAASNAADSLGRKI FT TEWRQPSK" FT misc_feature 141438..141467 FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS 142205..143053 FT /transl_table=11 FT /locus_tag="Rv1978" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1978, (MTV051.16), len: 282 aa. Conserved FT hypothetical protein, similar to several hypothetical FT proteins and methyltransferases e.g. X86780|SHGCPIR.15 FT methyltransferase from S. hygroscopicus (211 aa), FASTA FT scores: opt: 151, E(): 0.0072, (30.6% identity in 121 aa FT overlap). TBparse score is 0.933." FT /db_xref="InterPro:IPR013217" FT /db_xref="UniProtKB/TrEMBL:O53979" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17851.1" FT /translation="MGEANIREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVPDEV FT KQKIIGVLDRVGTLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILELHPTAT FT VTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHDHSYDLAVFALAFHHLPPTVA FT CKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVLLLPLHLLLLPWSSMRSSMHDGFISAL FT RAYSPSALQTLARAADPGMQVEILPAPTRLFPPSLAVVFSRSSSAPTESSECSADRQPG FT E" FT CDS complement(143016..144461) FT /transl_table=11 FT /locus_tag="Rv1979c" FT /product="POSSIBLE CONSERVED PERMEASE" FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF AMINO FT ACID ACROSS THE MEMBRANE." FT /note="(MTCY39.40-MTV051.17c), len: 481 aa. Possible FT permease, APC family possibly involved in transport of FT amino acid, showing some similarity to other permeases. FT Also similar to MTCY39.19 from Mycobacterium tuberculosis FT (28.2% identity in 277 aa overlap). Contains PS00599 FT Aminotransferases class-II pyridoxal-phosphate attachment FT site." FT /db_xref="GOA:Q10875" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/Swiss-Prot:Q10875" FT /protein_id="CAA17852.1" FT /translation="MVGPRTRGYAIHKLGFCSVVMLGINSIIGAGIFLTPGEVIGLAGP FT FAPMAYVLAGIFAGVVAIVFATAARYVRTNGASYAYTTAAFGRRIGIYVGVTHAITASI FT AWGVLASFFVSTLLRVAFPDKAWADAEQLFSVKTLTFLGFIGVLLAINLFGNRAIKWAN FT GTSTVGKAFALSAFIVGGLWIITTQHVNNYATAWSAYSATPYSLLGVAEIGKGTFSSMA FT LATIVALYAFTGFESIANAAEEMDAPDRNLPRAIPIAIFSVGAIYLLTLTVAMLLGSNK FT IAASDDTVKLAAAIGNATFRTIIVVGALISMFGINVAASFGAPRLWTALADSGVLPTRL FT SRKNQYDVPMVSFAITASLALAFPLALRFDNLHLTGLAVIARFVQFIIVPIALIALARS FT QAVEHAAVRRNAFTDKVLPLVAIVVSVGLAVSYDYRCIFLVRGGPNYFSIALIVITFVV FT VPAMAYLHYYRIIRRVGDRPSTR" FT misc_feature complement(143934..143963) FT /note="PS00599 Aminotransferases class-II FT pyridoxal-phosphate attachment site" FT CDS complement(144640..145326) FT /transl_table=11 FT /gene="mpt64" FT /locus_tag="Rv1980c" FT /standard_name="mpb64" FT /product="IMMUNOGENIC PROTEIN MPT64 (ANTIGEN MPT64/MPB64)" FT /function="UNKNOWN" FT /note="Rv1980c, (MT2032, MTCY39.39), len: 228 aa. mpt64 FT (alternate gene name: mpb64), immunogenic protein FT (alternate gene name: mpb64) (see citations below), FT identical to MPT64|MPB64 from Mycobacterium bovis (228 aa). FT Similar to Rv3036c|MTV012.51c from Mycobacterium FT tuberculosis. Exported protein containing a N-terminal FT signal sequence: see notes below about proteomics." FT /db_xref="GOA:P0A5Q4" FT /db_xref="PDB:2HHI" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Q4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98382.1" FT /translation="MRIKIFMLVTAVVLLCCSGVATAAPKTYCEELKGTDTGQACQIQM FT SDPAYNINISLPSYYPDQKSLENYIAQTRDKFLSAATSSTPREAPYELNITSATYQSAI FT PPRGTQAVVLKVYQNAGGTHPTTTYKAFDWDQAYRKPITYDTLWQADTDPLPVVFPIVQ FT GELSKQTGQQVSIAPNAGLDPVNYQNFAVTNDGVIFFFNPGELLPEAAGPTQVLVPRSA FT IDSMLA" FT CDS complement(145517..146485) FT /transl_table=11 FT /gene="nrdF1" FT /locus_tag="Rv1981c" FT /standard_name="nrdF" FT /product="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) FT NRDF1 (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F FT PROTEIN)" FT /function="INVOLVED IN THE DNA REPLICATION PATHWAY. FT CATALYZES THE BIOSYNTHESIS OF DEOXYRIBONUCLEOTIDES FROM THE FT CORRESPONDING RIBONUCLEOTIDES, PRECURSORS THAT ARE FT NECESSARY FOR DNA SYNTHESIS [CATALYTIC ACTIVITY: FT 2'-DEOXYRIBONUCLEOSIDE DIPHOSPHATE + OXIDIZED THIOREDOXIN + FT H(2)O = RIBONUCLEOSIDE DIPHOSPHATE + REDUCED THIOREDOXIN]." FT /EC_number="1.17.4.1" FT /note="Rv1981c, (MTCY39.38), len: 322 aa. nrdF1, FT ribonucleoside-diphosphate reductase, beta chain (EC FT 1.17.4.1) (see citation below), highly similar to others FT e.g. RIR4_SALTY|P17424 ribonucleoside-diphosphate reductase FT (319 aa), FASTA scores: opt: 1402, E(): 0, (66.0% identity FT in 315 aa overlap); etc. Also similar to Rv3048c|MTV012.63c FT from Mycobacterium tuberculosis. Contains PS00368 FT Ribonucleotide reductase small subunit signature. BELONGS FT TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FT FAMILY. COFACTOR: BINDS 2 IRON IONS (BY SIMILARITY). Note FT that previously known as nrdF." FT /db_xref="GOA:Q10840" FT /db_xref="HSSP:2R2F" FT /db_xref="InterPro:IPR000358" FT /db_xref="UniProtKB/Swiss-Prot:Q10840" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55444.1" FT /translation="MTGKLVERVHAINWNRLLDAKDLQVWERLTGNFWLPEKIPLSNDL FT ASWQTLSSTEQQTTIRVFTGLTLLDTAQATVGAVAMIDDAVTPHEEAVLTNMAFMESVH FT AKSYSSIFSTLCSTKQIDDAFDWSEQNPYLQRKAQIIVDYYRGDDALKRKASSVMLESF FT LFYSGFYLPMYWSSRGKLTNTADLIRLIIRDEAVHGYYIGYKCQRGLADLTDAERADHR FT EYTCELLHTLYANEIDYAHDLYDELGWTDDVLPYMRYNANKALANLGYQPAFDRDTCQV FT NPAVRAALDPGAGENHDFFSGSGSSYVMGTHQPTTDTDWDF" FT misc_feature complement(146138..146185) FT /note="PS00368 Ribonucleotide reductase small subunit FT signature" FT CDS complement(146710..147129) FT /transl_table=11 FT /locus_tag="Rv1982c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1982c, (MTCY39.37), len: 139 aa. Conserved FT hypothetical protein. BELONGS TO THE UPF0110 FAMILY. FT Similar to Rv0624|Z92772|MTY20H10.05 from Mycobacterium FT tuberculosis (131 aa), FASTA scores: opt: 288, E(): FT 4.1e-14, (40.2% identity in 127 aa overlap); also similar FT to Rv0624, Rv2759c, and Rv0609" FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/Swiss-Prot:P0A652" FT /protein_id="CAA98401.1" FT /translation="MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIV FT LTARHGPVARTIFERLRSEIGLSVSSFTAEHAAATQRAFLRYGKGRHRAALNFGDCMTY FT ATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA" FT CDS 147541..149217 FT /transl_table=11 FT /gene="PE_PGRS35" FT /locus_tag="Rv1983" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1983, (MTCY39.36c), len: 558 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see Brennan & Delogu 2002). Similar to FT other PE proteins e.g. Rv0977, etc. Contains PS00141 FT Eukaryotic and viral aspartyl proteases active site." FT /db_xref="GOA:Q10873" FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:Q10873" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55445.1" FT /translation="MSFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGAD FT EVSAAVAALFARFGQEYQAVSAQASAFHQQFVQTLNSASGSYAAAEATIASQLQTAQHD FT LLGAVNAPTETLLGRPLIGDGAPGTATSPNGGAGGLLYGNGGNGYSATASGVGGGAGGS FT AGLIGNGGAGGAGGPNAPGGAGGNGGWLLGNGGIGGPGGASSIPGMSGGAGGTGGAAGL FT LGWGANGGAGGLGDGVGVDRGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIHVTEPT FT VHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMGLPTGLSISGYSGGLYYIFAT FT YTTTVDFGNGIVTAPTAVNVVLLSIPTSPFAISTYFSALLADPTTTPFEAYFGAVGVDG FT VLGVGPNAVGPGPSIPTMALPGDLNQGVLIDAPAGELVFGPNPLPAPNVEVVGSPITTL FT YVKIDGGTPIPVPSIIDSGGVTGTIPSYVIGSGTLPANTNIEVYTSPGGDRLYAFNTND FT YRPTVISSGLMNTGFLPFRFQPVYIDYSPSGIGTTVFDHPA" FT misc_feature 148420..148455 FT /note="PS00141 Eukaryotic and viral aspartyl proteases FT active site" FT CDS complement(149205..149858) FT /transl_table=11 FT /gene="cfp21" FT /locus_tag="Rv1984c" FT /product="PROBABLE CUTINASE PRECURSOR CFP21" FT /function="HYDROLYZES CUTIN." FT /EC_number="3.1.1.-" FT /note="Rv1984c, (MTCY39.35), len: 217 aa. cfp21, probable FT cutinase precursor with N-terminal signal sequence (EC FT 3.1.1.-), similar to P41744|CUTI_ALTBR cutinase precursor FT from Alternaria brassicicola (209 aa), FASTA scores: opt: FT 283, E(): 2.2e-11, (32.6% identity in 193 aa overlap). Also FT similar to Mycobacterium tuberculosis proteins e.g. Rv3452, FT Rv3451, Rv2301, Rv1758, Rv3724. BELONGS TO THE CUTINASE FT FAMILY." FT /db_xref="GOA:P63879" FT /db_xref="HSSP:1G66" FT /db_xref="InterPro:IPR011150" FT /db_xref="UniProtKB/Swiss-Prot:P63879" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98399.1" FT /translation="MTPRSLVRIVGVVVATTLALVSAPAGGRAAHADPCSDIAVVFARG FT THQASGLGDVGEAFVDSLTSQVGGRSIGVYAVNYPASDDYRASASNGSDDASAHIQRTV FT ASCPNTRIVLGGYSQGATVIDLSTSAMPPAVADHVAAVALFGEPSSGFSSMLWGGGSLP FT TIGPLYSSKTINLCAPDDPICTGGGNIMAHVSYVQSGMTSQAATFAANRLDHAG" FT misc_feature complement(149499..149516) FT /note="PS00155 Cutinase, serine active site" FT CDS complement(150288..151199) FT /transl_table=11 FT /locus_tag="Rv1985c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LYSR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv1985c, (MTCY39.34), len: 303 aa. Probable FT transcriptional regulatory protein, LysR family member. FT Similar to many regulatory proteins, especially FT ICIA_ECOLI|P24194 chromosome initiation inhibitor from FT Escherichia coli (297 aa), FASTA scores: opt: 520, E(): FT 1.1e-28, (35.8% identity in 285 aa overlap); and FT P94632|LYSG_CORGL LYSINE EXPORT REGULATOR PROTEIN (290 aa), FT FASTA scores: opt: 705, E(): 0, (42.7% identity in 288 aa FT overlap); etc. Contains PS00044 Bacterial regulatory FT proteins, lysR family signature. Also contains FT helix-turn-helix motif at aa 22-43,(+5.52 SD). BELONGS TO FT THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:P67665" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67665" FT /protein_id="CAA98410.1" FT /translation="MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLE FT QQVGQVLVVREKPCRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRITIAVNAD FT SMATWFSAVFDGLGDVLLDVRIEDQDHSARLLREGVAMGAVTTERNPVPGCRVHPLGEM FT RYLPVASRPFVQRHLSDGFTAAAAAKAPSLAWNRDDGLQDMLVRKAFRRAITRPTHFVP FT TTEGFTAAARAGLGWGMFPEKLAASPLADGSFVRVCDIHLDVPLYWQCWKLDSPIIARI FT TDTVRAAASGLYRGQQRRRRPG" FT misc_feature complement(151056..151133) FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS 151308..151907 FT /transl_table=11 FT /locus_tag="Rv1986" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF FT LYSINE ACROSS THE MEMBRANE." FT /note="Rv1986, (MTCY39.33c), len: 199 aa. Probable FT conserved integral membrane protein, LysE family possibly FT involved in transport of Lysine, similar to FT P11667|YGGA_ECOLI hypothetical 23.2 kDa protein in sbm-fba FT intergenic region (211 aa), FASTA scores: opt: 379, E(): FT 1.5e-19, (37.3% identity in 185 aa overlap); and FT Q11154|Rv0488 HYPOTHETICAL 20.9 kDa PROTEIN from M. FT tuberculosis (201 aa), FASTA scores: opt: 784, E(): 0, FT (63.4% identity in 186 aa overlap). BELONGS TO THE FT LYSE/YGGA FAMILY." FT /db_xref="GOA:P64903" FT /db_xref="InterPro:IPR001123" FT /db_xref="UniProtKB/Swiss-Prot:P64903" FT /protein_id="CAA98398.1" FT /translation="MNSPLVVGFLACFTLIAAIGAQNAFVLRQGIQREHVLPVVALCTV FT SDIVLIAAGIAGFGALIGAHPRALNVVKFGGAAFLIGYGLLAARRAWRPVALIPSGATP FT VRLAEVLVTCAAFTFLNPHVYLDTVVLLGALANEHSDQRWLFGLGAVTASAVWFATLGF FT GAGRLRGLFTNPGSWRILDGLIAVMMVALGISLTVT" FT CDS 152323..152751 FT /transl_table=11 FT /locus_tag="Rv1987" FT /product="POSSIBLE CHITINASE" FT /function="HYDROLYSIS OF CHITIN" FT /EC_number="3.2.1.14" FT /note="Rv1987, (MTCY39.32c), len: 142 aa. Possible FT chitinase (EC 3.2.1.14), similar to several e.g. FT P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA FT scores, opt: 324, E(): 1.2e-14, (39.5% identity in 129 aa FT overlap)." FT /db_xref="GOA:P64905" FT /db_xref="HSSP:1EXG" FT /db_xref="InterPro:IPR012291" FT /db_xref="UniProtKB/Swiss-Prot:P64905" FT /protein_id="CAA98397.1" FT /translation="MAGLNIYVRRWRTALHATVSALIVAILGLAITPVASAATARATLS FT VTSTWQTGFIARFTITNSSTAPLTDWKLEFDLPAGESVLHTWNSTVARSGTHYVLSPAN FT WNRIIAPGGSATGGLRGGLTGSYSPPSSCLLNGQYPCT" FT CDS 152977..153516 FT /transl_table=11 FT /locus_tag="Rv1988" FT /product="PROBABLE METHYLTRANSFERASE" FT /function="THOUGHT TO CAUSE METHYLATION" FT /EC_number="2.1.1.-" FT /note="Rv1988, (MTCY39.31c), len: 179 aa. Probable FT methyltransferase (EC 2.1.1.-), similar to FT ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370 FT aa), FASTA scores: opt: 259, E(): 2e-11, (35.1% identity in FT 171 aa overlap); contains PS00092 N-6 Adenine-specific DNA FT methylases signature. Also similar to Mycobacterium FT tuberculosis Rv1010 ksgA 16S rRNA dimethyltransferase." FT /db_xref="GOA:Q10838" FT /db_xref="InterPro:IPR002052" FT /db_xref="UniProtKB/TrEMBL:Q10838" FT /protein_id="CAA98396.1" FT /translation="MSALGRSRRAWGWHRLHDEWAARVVSAAAVRPGELVFDIGAGEGA FT LTAHLVRAGARVVAVELHPRRVGVLRERFPGITVVHADAASIRLPGRPFRVVANPPYGI FT SSRLLRTLLAPNSGLVAADLVLQRALVCKFASRNARRFTLTVGLMLPRRAFLPPPHVDS FT AVLVVRRRKCGDWQGR" FT misc_feature 153262..153282 FT /note="PS00092 N-6 Adenine-specific DNA methylases FT signature" FT CDS complement(154036..154596) FT /transl_table=11 FT /locus_tag="Rv1989c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1989c, (MTCY39.30), len: 186 aa. Hypothetical FT unknown protein." FT /db_xref="GOA:P64907" FT /db_xref="InterPro:IPR014914" FT /db_xref="UniProtKB/Swiss-Prot:P64907" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98395.1" FT /translation="MSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFG FT GRWNPPLLFPAIYLADSAQACMVEVERAAQAASTTAEKMLEAAYRLHTIDVTDLAVLDL FT TTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQRTR FT PGQLQLRQSVDLTPALYQELRAT" FT CDS complement(154593..154934) FT /transl_table=11 FT /locus_tag="Rv1990c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv1990c, (MTCY39.29), len: 113 aa. Probable FT transcriptional regulatory protein, similar to FT Mycobacterium tuberculosis Rv3188|AL021646|MTV014.32 (115 FT aa), FASTA scores: opt: 184, E(): 8.2e-07, (28.4% identity FT in 109 aa overlap). Contains probable helix-turn-helix FT motif at aa 20-44 (+4.22 SD)." FT /db_xref="UniProtKB/Swiss-Prot:P64909" FT /protein_id="CAA98394.1" FT /translation="MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVP FT QRLNKQRLIELAYVADALAEVLPRDQANVWMFSPNRLLEHRKPADLVRDGEYQRVLALI FT DAMAEGVFV" FT CDS complement(155178..155513) FT /transl_table=11 FT /locus_tag="Rv1990A" FT /product="POSSIBLE DEHYDROGENASE (FRAGMENT)" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv1990A, len: 111 aa. Possible dehydrogenase FT (fragment) (EC 1.-.-.-), similar to N-terminal part of FT several dehydrogenases and hypothetical proteins, e.g. FT Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis FT (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% FT identity in 78 aa overlap), but lacks C-terminal part. FT Maybe a pseudogene. Also similar to U17129|RSU17129_7 FT putative short-chain alcohol dehydrogenase from Rhodococcus FT erythropolis (275 aa), FASTA scores: opt: 142, E(): 0.018, FT (54.15% identity in 48 aa overlap)." FT /db_xref="GOA:Q8VJS7" FT /db_xref="InterPro:IPR002198" FT /db_xref="UniProtKB/TrEMBL:Q8VJS7" FT /protein_id="CAE55446.1" FT /translation="MGRLEGKVAFITGVARGQGRSHAVRLADGQARALGKVDVEACGAL FT VGEVEVWGRDVRDDRRVFVESPADEFGACRRVARQGIRVVGLPVSQRELVEPEAGCAAR FT RSAAGSQ" FT CDS complement(155602..155946) FT /transl_table=11 FT /locus_tag="Rv1991c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1991c, (MTCY39.28), len: 114 aa. Conserved FT hypothetical protein, showing some similarity to FT P13976|PEMK_ECOLI pemk protein (133 aa), FASTA scores: opt: FT 113, E(): 0.043, (29.2% identity in 113 aa overlap); and FT P96622|YDCE PROTEIN from Bacillus subtilis (116 aa), FASTA FT scores: opt: 227, E(): 6.9e-09, (37.4% identity in 115 aa FT overlap). Also similar to Mycobacterium tuberculosis FT Rv2801c, and Rv0659c." FT /db_xref="GOA:P64911" FT /db_xref="HSSP:1NE8" FT /db_xref="InterPro:IPR011067" FT /db_xref="UniProtKB/Swiss-Prot:P64911" FT /protein_id="CAA98393.1" FT /translation="MVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIA FT AVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTAIVTLNKTDLTDRVGEVPASLMHEV FT DRGLRRVLDL" FT CDS complement(156288..158603) FT /transl_table=11 FT /gene="ctpG" FT /locus_tag="Rv1992c" FT /product="PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE G FT CTPG" FT /function="METAL CATION-TRANSPORTING ATPASE; POSSIBLY FT CATALYZES THE TRANSPORT OF A UNDETERMINATED METAL CATION FT WITH THE HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O FT + UNDETERMINATED METAL CATION(IN) = ADP + PHOSPHATE + FT UNDETERMINATED METAL CATION(OUT)]." FT /EC_number="3.6.3.-" FT /note="Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG, FT metal cation-transporting P-type ATPase G (transmembrane FT protein) (EC 3.6.3.-), similar to others, especially FT cadmium-transporting ATPases (EC 3.6.3.3), e.g. FT NP_244904.1|NC_002570 cadmium-transporting ATPase from FT Bacillus halodurans (707 aa); P30336|CADA_BACFI PROBABLE FT CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa); FT BAB47609.1|AB037671 cadmium resistance protein B from FT Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO FT PROBABLE CADMIUM-TRANSPORTING ATPase from Listeria FT monocytogenes (707 aa); etc. Also similar to others from FT Mycobacterium tuberculosis e.g. Rv0969|MTCY10D7.05c|ctpV FT PUTATIVE CATION TRANSPORTER P-TYPE ATPASE V (770 aa); FT Rv1469; Rv0092; etc. Contains PS00435 Peroxidases proximal FT heme-ligand signature and PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB." FT /db_xref="GOA:P63689" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:P63689" FT /protein_id="CAA98411.1" FT /translation="MTTVVDAEVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGKV FT AGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYASRSASNRKAGV FT VQKIIDWSTRTLSGVRRDVAAQPSGETSDACCDGEDNEDREPEQLWQVAKLRRAAFSGV FT LLTASLVAAWAYPLWPVVLGLKALALAVGASTFVPSSLKRLAEGRVGVGTLMTIAALGA FT VALGELGEAATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQATVLREGTETIVAST FT ELHVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEVGPGDEVFAGSINGLGV FT LQVGVTATAANNSLARIVHIVEAEQVRKGASQRLADCIARPLVPSIMIAAALIAGTGSV FT LGNPLVWIERALVVLVAAAPCALAIAVPVTVVASIGAASRLGVLIKGGAALETLGTIRA FT VALDKTGTLTANRPVVIDVATTNGATREEVLAVAAALEARSEHPLAVAVLAATQATTAA FT SDVQAVPGAGLIGRLDGRVVRLGRPGWLDAAELADHVACMQQAGATAVLVERDQQLLGA FT IAVRDELRPEAAEVVAGLRTGGYQVTMLTGDNHATAAALAAQAGIEQVHAELRPEDKAH FT LVAQLRARQPTAMVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMGQDLRHLPQ FT ALDHARRSRQIMVQNVGLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIANGVRAG FT RIKPLAGPPKTPDRTIPG" FT misc_feature complement(157200..157220) FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT misc_feature complement(158451..158483) FT /note="PS00435 Peroxidases proximal heme-ligand signature" FT CDS complement(158600..158872) FT /transl_table=11 FT /locus_tag="Rv1993c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1993c, (MTCY39.26), len: 90 aa. Conserved FT hypothetical protein, very similar to FT Rv3269|Z92771|MTCY71.09 hypothetical protein from FT Mycobacterium tuberculosis (93 aa), FASTA results: opt: FT 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also FT similar to Rv0968 (98 aa) (51.1% identity in 94 aa FT overlap)." FT /db_xref="InterPro:IPR009963" FT /db_xref="UniProtKB/Swiss-Prot:P64913" FT /protein_id="CAA98412.1" FT /translation="MVTHELLVKAAGAVLTGLVGVSAYETLRKALGTAPIRRASVTVME FT WGLRGTRRAEAAAESARLTVADVVAEARGRIGEEAPLPAGARVDE" FT CDS complement(158925..159281) FT /transl_table=11 FT /locus_tag="Rv1994c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv1994c, (MTCY39.25), len: 118 aa. Probable FT transcription regulator, similar to MERR_STRLI|P30346 FT probable mercury resistance operon repressor (125 aa), FT FASTA scores: opt: 199, E(): 3e-08, (36.3% identity in 102 FT aa overlap). Contains probable helix-turn-helix motif at aa FT 36-57 (+3.78 SD)." FT /db_xref="GOA:P67731" FT /db_xref="InterPro:IPR011991" FT /db_xref="PDB:2JSC" FT /db_xref="UniProtKB/Swiss-Prot:P67731" FT /protein_id="CAA98392.1" FT /translation="MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHLG FT LTRSNVSNHLSCLRGCGLVVATYEGRQVRYALADSHLARALGELVQVVLAVDTDQPCVA FT ERAASGEAVEMTGS" FT CDS 159438..160205 FT /transl_table=11 FT /locus_tag="Rv1995" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1995, (MTCY39.24c), len: 255 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR012312" FT /db_xref="UniProtKB/Swiss-Prot:P64915" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98391.1" FT /translation="MVASGAATKGVTVMKQTPPAAVGRRHLLEISASAAGVIALSACSG FT SPPEPGKGRPDTTPEQEVPVTAPEDLMREHGVLKRILLIYREGIRRLQADDQSPAPALN FT ESAQIIRRFIEDYHGQLEEQYVFPKLEQAGKLTDITSVLRTQHQRGRVLTDRVLAATTA FT AAAFDQPARDTLAQDMAAYIRMFEPHEAREDTVVFPALRDVMSAVEFRDMAETFEDEEH FT RRFGEAGFQSVVDKVADIEKSLGIYDLSQFTPS" FT CDS 160301..161254 FT /transl_table=11 FT /locus_tag="Rv1996" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1996, (MTCY39.23c), len: 317 aa. Conserved FT hypothetical protein. Similar to several Mycobacterium FT tuberculosis hypothetical proteins e.g. FT Rv2005c|Q10851|YK05_MYCTU (295 aa), FASTA scores: opt: 775, FT E(): 0, (50.3% identity in 316 aa overlap); Rv2026c (294 FT aa) (47.9% identity in 311 aa overlap); and Rv2623, etc. FT Also similar to SCJ1.30c|AL109962 hypothetical protein from FT Streptomyces coelicolor (328 aa)." FT /db_xref="GOA:P0A5F7" FT /db_xref="InterPro:IPR006016" FT /db_xref="UniProtKB/Swiss-Prot:P0A5F7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98390.1" FT /translation="MSAQQTNLGIVVGVDGSPCSHTAVEWAARDAQMRNVALRVVQVVP FT PVITAPEGWAFEYSRFQEAQKREIVEHSYLVAQAHQIVEQAHKVALEASSSGRAAQITG FT EVLHGQIVPTLANISRQVAMVVLGYRGQGAVAGALLGSVSSSLVRHAHGPVAVIPEEPR FT PARPPHAPVVVGIDGSPTSGLAAEIAFDEASRRGVDLVALHAWSDMGPLDFPRLNWAPI FT EWRNLEDEQEKMLARRLSGWQDRYPDVVVHKVVVCDRPAPRLLELAQTAQLVVVGSHGR FT GGFPGMHLGSVSRAVVNSGQAPVIVARIPQDPAVPA" FT CDS 161456..164173 FT /transl_table=11 FT /gene="ctpF" FT /locus_tag="Rv1997" FT /product="PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE A FT CTPF" FT /function="METAL CATION-TRANSPORTING ATPASE; POSSIBLY FT CATALYZES THE TRANSPORT OF A UNDETERMINATED METAL CATION FT WITH THE HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O FT + UNDETERMINATED METAL CATION(IN) = ADP + PHOSPHATE + FT UNDETERMINATED METAL CATION(OUT)]." FT /EC_number="3.6.3.-" FT /note="Rv1997, (MTCY39.22c, MTCY39.21c), len: 905 aa. FT Probable ctpF, metal cation-transporting P-type ATPase F FT (transmembrane protein) (EC 3.6.3.-), highly similar to FT others e.g. NP_250120.1|NC_002516 probable FT cation-transporting P-type ATPase from Pseudomonas FT aeruginosa (902 aa); NP_441217.1|NC_000911 FT cation-transporting ATPase (E1-E2 ATPase) from FT Synechocystis sp. strain PCC 6803 (905 aa); FT NP_404093.1|NC_003143 putative cation-transporting P-type FT ATPase from Yersinia pestis (908 aa); P37367|ATA1_SYNY3 FT cation-transporting ATPase pma1 from Synechocystis sp. (915 FT aa), FASTA scores: opt: 2392, E(): 0, (46.5% identity in FT 852 aa overlap); etc. Contains PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Was FT frame-shifted in original cosmid sequence." FT /db_xref="GOA:P63687" FT /db_xref="HSSP:1EUL" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:P63687" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98413.1" FT /translation="MSASVSATTAHHGLPAHEVVLLLESDPYHGLSDGEAAQRLERFGP FT NTLAVVTRASLLARILRQFHHPLIYVLLVAGTITAGLKEFVDAAVIFGVVVINAIVGFI FT QESKAEAALQGLRSMVHTHAKVVREGHEHTMPSEELVPGDLVLLAAGDKVPADLRLVRQ FT TGLSVNESALTGESTPVHKDEVALPEGTPVADRRNIAYSGTLVTAGHGAGIVVATGAET FT ELGEIHRLVGAAEVVATPLTAKLAWFSKFLTIAILGLAALTFGVGLLRRQDAVETFTAA FT IALAVGAIPEGLPTAVTITLAIGMARMAKRRAVIRRLPAVETLGSTTVICADKTGTLTE FT NQMTVQSIWTPHGEIRATGTGYAPDVLLCDTDDAPVPVNANAALRWSLLAGACSNDAAL FT VRDGTRWQIVGDPTEGAMLVVAAKAGFNPERLATTLPQVAAIPFSSERQYMATLHRDGT FT DHVVLAKGAVERMLDLCGTEMGADGALRPLDRATVLRATEMLTSRGLRVLATGMGAGAG FT TPDDFDENVIPGSLALTGLQAMSDPPRAAAASAVAACHSAGIAVKMITGDHAGTATAIA FT TEVGLLDNTEPAAGSVLTGAELAALSADQYPEAVDTASVFARVSPEQKLRLVQALQARG FT HVVAMTGDGVNDAPALRQANIGVAMGRGGTEVAKDAADMVLTDDDFATIEAAVEEGRGV FT FDNLTKFITWTLPTNLGEGLVILAAIAVGVALPILPTQILWINMTTAIALGLMLAFEPK FT EAGIMTRPPRDPDQPLLTGWLVRRTLLVSTLLVASAWWLFAWELDNGAGLHEARTAALN FT LFVVVEAFYLFSCRSLTRSAWRLGMFANRWIILGVSAQAIAQFAITYLPAMNMVFDTAP FT IDIGVWVRIFAVATAITIVVATDTLLPRIRAQPP" FT misc_feature 162452..162472 FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT CDS complement(164242..165018) FT /transl_table=11 FT /locus_tag="Rv1998c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1998c, (MTCY39.20), len: 258 aa. Conserved FT hypothetical protein, showing some similarity with other FT hypothetical proteins e.g. U82823|SEU82823.03 FT Saccharopolyspora erythraea (266 aa), FASTA results: opt: FT 654, E(): 0, (43.8% identity in 249 aa overlap); and FT AL034446|SC1A9.07 Streptomyces coelicolor (251 aa), FASTA FT scores: opt: 592, E(): 1.5e-31, (43.4% identity in 251 aa FT overlap)." FT /db_xref="GOA:Q10859" FT /db_xref="InterPro:IPR015813" FT /db_xref="UniProtKB/Swiss-Prot:Q10859" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98389.1" FT /translation="MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSSS FT GGHPDGHRATRGANIALAAALAPLQCYVSVDIEDGYSDEPDAIADYVAQLSTAGINIED FT SSAEKLIDPALAAAKIVAIKQRNPEVFVNARVDTYWLRQHADTTSTIQRALRYVDAGAD FT GVFVPLANDPDELAELTRNIPCPVNTLPVPGLTIADLGELGVARVSTGSVPYSAGLYAA FT AHAARAVSDGEQLPRSVPYAELQARLVDYENRTSTT" FT CDS complement(165113..166435) FT /transl_table=11 FT /locus_tag="Rv1999c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN. POSSIBLY TRANSPORTER INVOLVED IN FT TRANSPORT OF UNDETERMINATED SUBSTRATE (POSSIBLY CATIONIC FT AMINO ACIDS) ACROSS THE MEMBRANE: SO RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1999c, (MTCY39.19), len: 440 aa. Probable FT conserved integral membrane protein, possibly transporter FT of cationic amino acid, similar to many transporters, FT especially amino acid transporters, e.g. FT CAC08265.1|AL392146 putative amino acid transporter from FT Streptomyces coelicolor (414 aa); P39277|YJEH_ECOLI FT hypothetical 44.8 kDa protein from Escherichia coli (418 FT aa), FASTA scores, opt: 343, E(): 6.6e-15, (27.2% identity FT in 408 aa overlap); etc. Also similar to Rv1979c from FT Mycobacterium tuberculosis, FASTA score: (28.2% identity in FT 277 aa overlap); Rv2127, Rv0346c, Rv0522, etc. SEEMS TO FT BELONG TO THE APC FAMILY." FT /db_xref="GOA:P63349" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/Swiss-Prot:P63349" FT /protein_id="CAA98388.1" FT /translation="MRRPLDPRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAY FT AAGSGLLLGLAVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVV FT GKTASCAAMALTVGFYVWPAQAHAVAVAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVL FT TAVVVAAYGSGAADPARLDIGVDAHVWGMLQAAGLLFFAFAGYARIATLGEEVRDPART FT IPRAIPLALGITLAVYALVAVAVIAVLGPQRLARAAAPLSEAMRVAGVNWLIPVVQIGA FT AVAALGSLLALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAAT FT ADIRGAIGFSSFGVLVYYAIANASALTLGLDEGRPRRLIPLVGLIGCVVLAFALPLSSV FT AAGAAVLGVGVAAYGVRRIITRRARQTDSGDTQRSGHPSAT" FT CDS 166506..168119 FT /transl_table=11 FT /locus_tag="Rv2000" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2000, (MTCY39.18c), len: 537 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64917" FT /protein_id="CAA98387.1" FT /translation="MRPGFVGLGFGQWPVYVVRWPKLHLTPRQRKRVLHRRRLLTDRPI FT SLSQIPIRTGGPMNDPWPRPTQGPAKTIETDYLVIGAGAMGMAFTDTLITESGARVVMI FT DRACQPGGHWTTAYPFVRLHQPSAYYGVNSRALGNNTIDLVGWNQGLNELAPVGEICAY FT FDAVLQQQLLPTGRVDYFPMSEYLGDGRFRTLAGTEYVVTVNRRIVDATYLRAVVPSMR FT PAPYSVAPGVDCVAPNELPKLGTRDRYVVVGAGKTGMDVCLWLLRNDVCPDKLTWIMPR FT DSWLIDRATLQPGPTFVRQFRESYGATLEAIGAATSTDDLFDRLETAGTLLRIDPSVRP FT SMYRCATVSHLELEQLRRIRDIVRMGHVQRIEPTTIVLDGGSVPATPTALYIDCTADGA FT PQRPAKPVFDADHLTLQAVRGCQQVFSAAFIAHVEFAYEDDAVKNELCTPIPHPDCDLD FT WMRLMHSDLGNFQRWLNDPDLTDWLSSARLNLLADLLPPLSHKPRVRERVVSMFQKRLG FT TAGDQLAKLLDAATATTEQR" FT CDS 168129..168881 FT /transl_table=11 FT /locus_tag="Rv2001" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2001, (MTCY39.17c), len: 250 aa. Conserved FT hypothetical protein. Similar to Mycobacterium tuberculosis FT Rv0466, AL021933|MTV038_10 (264 aa), FASTA scores: opt: FT 592, E():0, (38.0% identity in 263 aa overlap)." FT /db_xref="InterPro:IPR002864" FT /db_xref="UniProtKB/Swiss-Prot:Q10856" FT /protein_id="CAA98386.1" FT /translation="MHHNRDVDLALVERPSSGYVYTTGWRLATTDIDEHQQLRLDGVAR FT YIQEVGAEHLADAQLAEVHPHWIVLRTVIDVINPIELPSDITFHRWCAALSTRWCSMRV FT QLQGSAGGRIETEGFWICVNKDTLTPSRLTDDCIARFGSTTENHRLKWRPWLTGPNIDG FT TETPFPLRRTDIDPFEHVNNTIYWHGVHEILCQIPTLTAPYRAVLEYRSPIKSGEPLTI FT RYEQHDDVVRMHFVVGDDVRAAALLRRL" FT CDS 168957..169739 FT /transl_table=11 FT /gene="fabG3" FT /locus_tag="Rv2002" FT /product="POSSIBLE 20-BETA-HYDROXYSTEROID DEHYDROGENASE FT FABG3 (Cortisone reductase) ((R)-20-hydroxysteroid FT dehydrogenase)" FT /function="NOT REALLY KNOWN; THOUGHT TO BE INVOLVED IN FT LIPID BIOSYNTHESIS [CATALYTIC ACTIVITY: FT Androstan-3-alpha,17-beta-diol + NAD+ = FT 17-beta-hydroxyandrostan-3-one + NADH]." FT /EC_number="1.1.1.53" FT /note="Rv2002, (MTCY39.16c), len: 260 aa. Possible fabG3, FT 20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53), similar FT to e.g. 2BHD_STREX|P19992 20-beta-hydroxysteroid FT dehydrogenase (255 aa), FASTA scores: opt: 718, E(): 2e-38, FT (49.8% identity in 243 aa overlap), and many mycobacterial FT proteins. Contains PS00061 Short-chain alcohol FT dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P69167" FT /db_xref="InterPro:IPR016040" FT /db_xref="PDB:1NFF" FT /db_xref="UniProtKB/Swiss-Prot:P69167" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98414.1" FT /translation="MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGK FT AVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTE FT WQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGL FT TKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASD FT ESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT" FT misc_feature 169374..169460 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS complement(169860..170717) FT /transl_table=11 FT /locus_tag="Rv2003c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2003c, (MTCY39.14), len: 285 aa. Conserved FT hypothetical protein. Some similarity with Methanococcus FT jannaschii 67555|U67555_3 (205 aa), FASTA scores: opt: 357, FT E(): 3.2e-17, (33.8% identity in 204 aa overlap)." FT /db_xref="GOA:P64919" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P64919" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98385.1" FT /translation="MVKRSRATRLSPSIWSGWESPQCRSIRARLLLPRGRSRPPNADCC FT WNQLAVTPDTRMPASSAAGRDAAAYDAWYDSPTGRPILATEVAALRPLIEVFAQPRLEI FT GVGTGRFADLLGVRFGLDPSRDALMFARRRGVLVANAVGEAVPFVSRHFGAVLMAFTLC FT FVTDPAAIFRETRRLLADGGGLVIGFLPRGTPWADLYALRAARGQPGYRDARFYTAAEL FT EQLLADSGFRVIARRCTLHQPPGLARYDIEAAHDGIQAGAGFVAISAVDQAHEPKDDHP FT LESE" FT CDS complement(170775..172271) FT /transl_table=11 FT /locus_tag="Rv2004c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2004c, (MTCY39.13), len: 498 aa. Conserved FT hypothetical protein similar to several e.g. >pir||T36945 FT hypothetical protein SCJ1.12 (508 aa) - Streptomyces FT coelicolor >gi|5748625|emb|CAB53130.1| (AL109962). FT Smith-Waterman score: 7e-94, Identities = 199/468 (42%). FT Contains PS00017 ATP/GTP-binding site motif A." FT /db_xref="GOA:P0A5F9" FT /db_xref="UniProtKB/Swiss-Prot:P0A5F9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98384.1" FT /translation="MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPV FT VTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQ FT RLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHH FT ADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALL FT DCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIA FT YRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLAR FT GVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLG FT SGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATA FT EIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI" FT misc_feature complement(171264..171287) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(172293..173180) FT /transl_table=11 FT /locus_tag="Rv2005c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2005c, (MTCY39.12), len: 295 aa. Conserved FT hypothetical protein, similar to MTCY39.23c, (50.3% FT identity in 316 aa overlap), C-terminus shows some FT similarity with YXIE_BACSU P42297 hypothetical 15.9 kd FT protein in bglh- (148 aa), FASTA scores, opt: 124, E(): FT 0.038, (28.5% identity in 144 aa overlap), also similar to FT Rv2623 (294 aa), (52.7% identity in 296 aa overlap) and FT other Mycobacterium tuberculosis hypothetical proteins e.g. FT Rv1996, Rv2624c, Rv2028c, Rv3134c, Rv1636. Some, possibly FT all, of these belong to universal stress protein family." FT /db_xref="GOA:P64921" FT /db_xref="InterPro:IPR006016" FT /db_xref="UniProtKB/Swiss-Prot:P64921" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98383.1" FT /translation="MSKPRKQHGVVVGVDGSLESDAAACWGATDAAMRNIPLTVVHVVN FT ADVATWPPMPYPETWGVWQEDEGRQIVANAVKLAKEAVGADRKLSVKSELVFSTPVPTM FT VEISNEAEMVVLGSSGRGALARGLLGSVSSSLVRRAGCPVAVIHSDDAVIPDPQHAPVL FT VGIDGSPVSELATAVAFDEASRRGVELIAVHAWSDVEVVELPGLDFSAVQQEAELSLAE FT RLAGWQERYPDVPVSRVVVCDRPARKLVQKSASAQLVVVGSHGRGGLTGMLLGSVSNAV FT LHAARVPVIVARQS" FT CDS 173299..177282 FT /transl_table=11 FT /gene="otsB1" FT /locus_tag="Rv2006" FT /standard_name="otsB" FT /product="PROBABLE TREHALOSE-6-PHOSPHATE PHOSPHATASE OTSB1 FT (TREHALOSE-PHOSPHATASE) (TPP)" FT /function="INVOLVED IN TREHALOSE BIOSYNTHESIS (PROTECTIVE FT EFFECT). Mycobacteria can produce trehalose from glucose FT 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from FT glycogen-like alpha(1-->4)-linked glucose polymers (the FT TreY-TreZ pathway) and from maltose (the TreS pathway) FT [CATALYTIC ACTIVITY: TREHALOSE 6-PHOSPHATE + H(2)O = FT TREHALOSE + ORTHOPHOSPHATE]." FT /EC_number="3.1.3.12" FT /note="Rv2006, (MTCY39.11c), len: 1327 aa. Probable otsB1, FT trehalose-6-phosphate phosphatase (EC 3.1.3.12) (see FT citations below); strong similarity in central domain to FT OTSB_ECOLI P31678 trehalose-phosphatase (266 aa) and M. FT leprae TREHALOSE-PHOSPHATASE Q49734 (429 aa). Belongs to FT Glycosyl hydrolases family 65 FT (http://www.expasy.ch/cgi-bin/lists?glycosid.txt). FASTA FT scores, sp|Q49734|Q49734 PUTATIVE TREHALOSE-PHOSPHATASE FT (429 aa) opt: 1283 E(): 0; 51.7% identity in 420 aa overlap FT opt: 278, E(): 3.6e-11, (29.4% identity in 255 aa overlap). FT Note that previously known as otsB." FT /db_xref="GOA:Q10850" FT /db_xref="InterPro:IPR003337" FT /db_xref="UniProtKB/Swiss-Prot:Q10850" FT /protein_id="CAE55447.1" FT /translation="MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTK FT FLDDYLTRRPQRTGEDHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDLTDDT FT VYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSHRNYGHTLDATGLA FT EVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANPGRCVVIDSCQTGLRAGRNGGFA FT LVIAVDAHGDAENLLSSGADAVVADLAAVTVGSGDAAISTIPDALQVYSQLKRLLTGRR FT PAVFLDFDGTLSDIVERPEAATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDG FT LWLAGSHGFELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAV FT HYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDWIGERLGPA FT EVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVRHNEHGDRRSAATFRLECPYTVCQF FT LSQLACDLQEAVQHDDPWTLVFHGYDPGQERLREALCAVGNGYLGSRGCAPESAESEAH FT YPGTYVAGVYNQLTDHIEGCTVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQT FT FDLRRATLTRSLRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLV FT DGGVHNTLVDRYRQLSSQHLTTAEIEVLADSVLLRTQTSQSGIAIAVAARSTLWRDGQR FT VDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDAATLTAAISAQRCLGEAG FT RYAELCQQHVRAWARLWERCAIDLTGNTEELRLVRLHLLHLLQTISPHTAELDAGVPAR FT GLNGEAYRGHVFWDALFVAPVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYP FT WQSGSDGSEVSQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCG FT AELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNVMAVW FT VILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFHDGVISQFEGYSEL FT AELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQADALMLLYLLSSDELIGLLARL FT GYRFAPTQIPGTVDYYLARTSDGSTLSAVVHAWVLARANRSNAMEYFRQVLRSDIADVQ FT GGTTQEGIHLAAMAGSIDLLQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLS FT LRISGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR" FT misc_feature 173968..173994 FT /note="PS00148 Arginase family signature 2" FT CDS complement(177381..177725) FT /transl_table=11 FT /gene="fdxA" FT /locus_tag="Rv2007c" FT /product="PROBABLE FERREDOXIN FDXA" FT /function="INVOLVED IN ELECTRON TRANSFER." FT /note="Rv2007c, (MTCY39.10), len: 114 aa. Probable fdxA, FT ferredoxin, similar to e.g. FER_MYCSM P00215 ferredoxin, FT Mycobacterium smegmatis (106 aa), FASTA scores, opt: 448, FT E(): 1 .6e-21, (58.7% identity in 109 aa overlap), also FT similar to Rv0886|MTCY31.14, (34.2% identity in 117 aa FT overlap) and fdxC|Rv1177." FT /db_xref="GOA:P64122" FT /db_xref="HSSP:1H98" FT /db_xref="InterPro:IPR000813" FT /db_xref="UniProtKB/Swiss-Prot:P64122" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98408.1" FT /translation="MTYVIGSECVDVMDKSCVQECPVDCIYEGARMLYINPDECVDCGA FT CKPACRVEAIYWEGDLPDDQHQHLGDNAAFFHQVLPGRVAPLGSPGGAAAVGPIGVDTP FT LVAAIPVECP" FT CDS complement(177914..179239) FT /transl_table=11 FT /locus_tag="Rv2008c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2008c, (MTCY39.09), len: 441 aa. Conserved FT hypothetical protein. Contains PS00017 ATP/GTP-binding site FT motif A, PS00501 Signal peptidases I serine active site. FT Also contains helix-turn-helix motif at aa 258-279. Similar FT to several conserved hypothetical proteins e.g. FT NP_085874.1|14028123|dbj|BAB54715.1 hypothetical protein FT from Mesorhizobium loti (435 aa). Smith-Waterman score: FT 1e-74, Identities = 158/359 (44%)" FT /db_xref="GOA:P64923" FT /db_xref="UniProtKB/Swiss-Prot:P64923" FT /protein_id="CAA98407.1" FT /translation="MDEIESLIGLRPTPLTWPVVIAGDFLGVWDPPPSLPGAANHEISA FT PTARISCMLIERRDAAARLRRALHRAPVVLLTGPRQAGKTTLSRLVGKSAPECTFDAEN FT PVDATRLADPMLALSGLSGLITIDEAQRIPDLFPVLRVLVDRPVMPARFLILGSASPDL FT VGLASESLAGRVELVELSGLTVRDVGSSAADRLWLRGGLPPSFTARSNEDSAAWRDGYI FT TTFLERDLAQLGVRIPAATMRRAWTMLAHYHGQLFSGAELARSLDVAQTTARRYLDALT FT DALVVRQLTPWFANIGKRQRRSPKIYIRDTGLLHRLLGIDDRLALERNPKLGASWEGFV FT LEQLAALLAPNPLYYWRTQQDAELDLYVELSGRPYGFEIKRTSTPSISRSMRSALVDLQ FT LARLAIVYPGEHRFPLSDTVVAVPADQILTTGSVDELLALLK" FT misc_feature complement(178055..178078) FT /note="PS00501 Signal peptidases I serine active site" FT misc_feature complement(178985..179008) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 179327..179569 FT /transl_table=11 FT /locus_tag="Rv2009" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2009, (MTCY39.08c), len: 80 aa. Conserved FT hypothetical protein, very similar to Rv1560|MTCY48.05c FT (54.4% identity in 68 aa overlap)." FT /db_xref="InterPro:IPR019239" FT /db_xref="UniProtKB/Swiss-Prot:Q10848" FT /protein_id="CAA98406.1" FT /translation="MYSGVVSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEP FT LGRDEALALQGSGFDFSNDEIESFSDTDRKLADES" FT CDS 179570..179968 FT /transl_table=11 FT /locus_tag="Rv2010" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2010, (MTCY39.07c), len: 132 aa. Conserved FT hypothetical protein, similar to Rv1561|MTCY48.04c, (38.1% FT identity in 126 aa overlap)" FT /db_xref="InterPro:IPR006596" FT /db_xref="UniProtKB/Swiss-Prot:P64925" FT /protein_id="CAA98405.1" FT /translation="MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLI FT GKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAIHRRCRRGGDTVRSLIDCQVAAMAL FT RIGVAVAHRDRDYEAIRTHCGLRTEPLF" FT CDS complement(180151..180582) FT /transl_table=11 FT /locus_tag="Rv2011c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2011c, (MTCY39.06), len: 143 aa. Conserved FT hypothetical protein, some similarity to putative FT regulatory proteins e.g. putative marR-family regulatory FT protein from Streptomyces coelicolor A3(2) (157 aa), FT emb|CAB63189.1| (AL133469) 34% identity in 110 aa overlap. FT Low similarity to PETP_RHOCA P31078 petp protein. FT Rhodobacter capsulatus (166 aa), FASTA scores, opt: 101, FT E(): 0 .36, (31.8% identity in 88 aa overlap)" FT /db_xref="UniProtKB/Swiss-Prot:P64927" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98404.1" FT /translation="MSDEIARLVADVFELAGLLRRSGEVVAAREGHTQARWQLLSVVSD FT RALTVPQAARRLGVTRQGVQRVANDLVVCGLAELRHNPDHRTSPLLVLTENGRRVLQAI FT TERAIVVNNRLADAVDPAALQATRDSLRRMIVALKAERP" FT CDS 180623..181117 FT /transl_table=11 FT /locus_tag="Rv2012" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2012, (MTCY39.05c), len: 164 aa. Conserved FT hypothetical protein, similar to AAK04358.1|AE006263_5 FT hypothetical protein from Lactococcus lactis (137 aa), (48% FT identity in 129 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64929" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98403.1" FT /translation="MLSKSKRSCRRRETLRIGEKMSAPITNLQAAQRDAIMNRPAVNGF FT PHLAETLRRAGVRTNTWWLPAMQSLYETDYGPVLDQGVPLIDGVAEVPAFDRTALVTAL FT RADQAGQTSFREFAAAAWRAGVLRYVVDLENRTCTYFGLHDQTYMEHYAAVEPSGGAPT FT S" FT repeat_region 181740..182967 FT /mobile_element="insertion sequence:IS1607" FT /note="IS1607, len: 1228 bp. Vestigial Insertion sequence FT element, IS1607." FT CDS 181962..182441 FT /transl_table=11 FT /locus_tag="Rv2013" FT /product="POSSIBLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF AN INSERTION FT ELEMENT." FT /note="Rv2013, (MTCY39.04c), len: 159 aa. Possible FT transposase: shows similarity to N-terminal part of FT transposase and insertion element hypothetical proteins eg FT sp|Q53198|Y4UE_RHISN PUTATIVE TRANSPOSASE Y4UE (359 aa) FT opt: 383, E(): 1.3e-18; 35.1% identity in 225 aa overlap; FT sp|P 14707|YM3_STRCO MINI-CIRCLE HYPOTHETICAL 45.7 kDa P FT (414 aa) opt: 302, E(): 4.2e-13; 33.3% identity in 207 aa FT overlap; and YI90_MYCPA P14322 insertion element is900 FT hypothetical protein (399 aa), FASTA scores, opt: 146, E(): FT 0.0021, (26.9% identity in 145 aa overlap). Length changed FT since first submission (no clear start apparent)." FT /db_xref="GOA:Q10844" FT /db_xref="InterPro:IPR002525" FT /db_xref="UniProtKB/TrEMBL:Q10844" FT /protein_id="CAA98402.2" FT /translation="MDTLLEAGITVVVISPNQLKNLRGRYGSAGNKDDRFDAFVLADTL FT RTDRSRLRPLLPDTPATATLRRTCRPRKDLVAHRVALANQLRAHLRVVFPGVVGLFADL FT DSPISLAFLTFLPRFDCQDRADWLSVKRLAGWLAAAGYCGRAPRPAHRCPARRHR" FT CDS 182395..182985 FT /transl_table=11 FT /locus_tag="Rv2014" FT /product="POSSIBLE TRANSPOSASE" FT /function="REQUIRED FOR THE TRANSPOSITION OF AN INSERTION FT ELEMENT." FT /note="Rv2014, (MTCY39.03c), len: 196 aa. Possible FT transposase, similar to insertion elements e.g. FT sp|P14707|YM3_STRCO MINI-CIRCLE HYPOT HETICAL 45.7 kDa P FT (414 aa) opt: 249 z-score: 307.0 E(): 1.4e-09; 33.1% FT identity in 169 aa overlap; and YI90_MYCPA P14322 insertion FT element is900 hypothetical protein (399 a a), FASTA scores, FT opt: 242, z-score: 299.9, E(): 3.7e-10, (3 2.5% identity in FT 163 aa overlap); possibly made by frameshifting with FT respect to upstream ORF. Length changed since first FT submission." FT /db_xref="GOA:Q10843" FT /db_xref="InterPro:IPR003346" FT /db_xref="UniProtKB/TrEMBL:Q10843" FT /protein_id="CAA98415.2" FT /translation="MLHDRLTGAPRGATGDEGAANAHITRAMVAALTSVATQIKTLDAQ FT IAEQLSLHADAHIFTSLPRSGTVRAARLLAEIGDCRARFPTPESLACLAGVAPSTRQSG FT KVKHVGFRWAADKQLRDAVCDFAGDSRRANLWAADRYNRAIARGHDHPHAVRILARAWL FT YAIWHCWQDGAAYHPANHRALQALLNQDQDRAA" FT CDS complement(183113..184369) FT /transl_table=11 FT /locus_tag="Rv2015c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2015c, (MTV018.02c), len: 418 aa. Conserved FT hypothetical protein. Nearly identical to Mycobacterium FT tuberculosis Rv1765c|MTCY28.31c, (378 aa), an ORF starting FT next to ISB9, and ending in IS6110. Different N-terminus FT chosen and C-terminus differs as that of Rv1765c has been FT truncated by IS6110. Does NOT show similarities with FT transposases. BLAST hits with non-IS part of MTU78639. FT FASTA scores: Z95890|MTCY28_31 (378 aa) opt: 2417, E(): 0, FT (97.8% identity in 364 aa overlap). TBparse score is 0.939" FT /db_xref="GOA:O53461" FT /db_xref="InterPro:IPR003870" FT /db_xref="UniProtKB/TrEMBL:O53461" FT /protein_id="CAA17229.1" FT /translation="MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVAE FT LDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSLDQ FT VGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSADEQ FT FSCWRIKLPHVEAAKFDAALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAFLRLV FT EAGWDAEVARRPHGQHTTVVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEAWFERD FT GQVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGATELANLV FT LVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPPPAVAPWPGPTGE FT RADWWWYEPFQPQPPPISN" FT CDS 184723..185298 FT /transl_table=11 FT /locus_tag="Rv2016" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2016, (MTV018.03), len: 191 aa. Hypothetical FT protein. TBparse score is 0.927" FT /db_xref="UniProtKB/TrEMBL:O53462" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17230.1" FT /translation="MTELGDKFLAALVGTIRDTRFDIADMRNWRPGWFPTMHSRCLSNL FT IHDRIWAHLVTLIASNPGTSIKDKGATREIVVGAHLRLRIKRHHAGDEISTYPTRTAIE FT FWQQGSQPAFPGLEEVRIAVGYRWDPDTREIGAPLLSLRDGKDHVIWVVELDEPAAGVK FT ITWTPIEPTLPSIDFGDLGEDSGASGER" FT CDS 185295..186335 FT /transl_table=11 FT /locus_tag="Rv2017" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="THOUGH TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /note="Rv2017, (MTV018.04), len: 346 aa. Possible FT regulatory protein; shows similarity at N-terminal end to FT several transcriptional regulators e.g. Z99115|BSUB0012_44 FT from Bacillus subtilis (108 aa), FASTA scores: opt: 154, FT E(): 0.0012; (35.5% identity in 62 aa overlap). Contains FT PS00142 Neutral zinc metallopeptidases, zinc-binding region FT signature in C-terminal half, may be fortuitous. TBparse FT score is 0.908. Contains probable helix-turn-helix motif at FT aa 18-39 (Score 2243, +6.83 SD)." FT /db_xref="GOA:O53463" FT /db_xref="HSSP:2R63" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:O53463" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17231.1" FT /translation="MNGLGDVLAVARKARGLTQIELAELVGLTQPAINRYESGDRDPDQ FT HIVAKLAEILGVTDDLLIHGNRFRGALAVDAHMRRHKTTKASAWRQLEARLNLLRVHAS FT FLFEEVAINSEQHVPAFDPEFTAAEDAARLVRAQWRMPMGPVVNLTRWMEAAGCLVFEE FT DFATQRIDGLSQWVDDYPVMLINANAAPDRKRLTLAHELGHLVLHSTNPTENMETEATA FT FAAEFLMPESEIRPELRRLDLGKLLELKREWGVSMQALLARAYRMGLVSAEARTKLYKA FT MNARGWKTKEPGIESIVREKPSLPAHIGMTLRSRGFTDQQAAAIAGYANPADNPFRPEG FT GRLHAI" FT misc_feature 185883..185912 FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS 186577..187296 FT /transl_table=11 FT /locus_tag="Rv2018" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2018, (MTV018.05), len: 239 aa. Conserved FT hypothetical protein, similar to Rv2308|MTCY339.01c (238 FT aa). FASTA scores: Z77163|MTCY339_1 Mycobacterium FT tuberculosis cosmid (238 aa) opt: 142, E(): 0.029; (24.8% FT identity in 250 aa overlap). Contains probable FT helix-turn-helix motif at aa 215-236 (Score 1175, +3.19 FT SD). TBparse score is 0.929." FT /db_xref="InterPro:IPR007367" FT /db_xref="UniProtKB/TrEMBL:O53464" FT /protein_id="CAA17232.1" FT /translation="MAGDQELELRFDVPLYTLAEASRYLVVPRATLATWADGYERRPAN FT APAVQGQPIITALPHPTGSHARLPFVGIAEAYVLNAFRRAGVPMQRIRPSLDWLIKNVG FT PHALASQDLCTDGAEVLWRFAERSGEGSPDDLVVRGLIVPRSGQYVFKEIVEHYLQQIS FT FADDNLASMIRLPQYGDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADD FT YGVTPDQLRDALDAIAA" FT CDS 187286..187702 FT /transl_table=11 FT /locus_tag="Rv2019" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2019, (MTV018.06), len: 138 aa. Hypothetical FT protein." FT /db_xref="UniProtKB/TrEMBL:O53465" FT /protein_id="CAA17233.1" FT /translation="MQPDRNLLADLDHIFVDRSLGAVQVPQLLRDAGFRLTTMREHYGE FT TQAQSVSDHKWIAMTAECGWIGFHKDANIRRNAVERRTVLDTGARLFCVPRADILAEQV FT AARYIASLAAIARAARFPGPFIYTVHPSKIVRVL" FT CDS complement(187718..188017) FT /transl_table=11 FT /locus_tag="Rv2020c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2020c, (MTV018.07c), len: 99 aa. Conserved FT hypothetical protein, nearly identical to C-terminal part FT of hypothetical protein RvD1-Rv2024c' from Mycobacterium FT bovis BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds FT to deletion region RvD1 so probably truncated protein. FT TBparse score is 0.891" FT /db_xref="UniProtKB/TrEMBL:O53466" FT /protein_id="CAA17234.1" FT /translation="MAPGMKWAAKTDHLAIVLLPRHHRRHSRRGRALPARSRSALGWII FT ERYRVTTDKASGIVNDPNDWCDEHDDPTYIVDLIKKVTTVSVETMKIVDGLAGG" FT CDS complement(188102..188407) FT /transl_table=11 FT /locus_tag="Rv2021c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="THOUGH TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /note="Rv2021c, (MTV018.08c), len: 101 aa. Possible FT regulatory protein, similar to Rv3183|MTV014.27|AL021646 FT POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN from M. FT tuberculosis (109 aa), FASTA scores: opt: 214, E(): FT 1.2e-09, (43.0% identity in 107 aa overlap). TBparse score FT is 0.913. Contains probable helix-turn-helix at aa 45-66 FT (Score 1472, +4.20 SD)." FT /db_xref="GOA:O53467" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/TrEMBL:O53467" FT /protein_id="CAA17235.1" FT /translation="MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLT FT QVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYVSALGGELDITVRLGDETFTLA" FT CDS complement(188416..189021) FT /transl_table=11 FT /locus_tag="Rv2022c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2022c, (MTV018.09c), len: 201 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical protein Rv3182, MTV014.26 (EMBL:AL 021646). FT FASTA scores; TR:E1248773 (114 aa) opt: 335, E(): 3e-22, FT 53.8% identity in 106 aa overlap and to hypothetical FT proteins from Yersinia pestis (115 aa) e.g. emb|CAB53172.1| FT (AL109969), 41% identity in 108 aa overlap. TBparse score FT is 0.912" FT /db_xref="InterPro:IPR018670" FT /db_xref="UniProtKB/TrEMBL:O53468" FT /protein_id="CAA17236.1" FT /translation="MNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHF FT LDGSPVARCSYPEEYHPCVISRIALLCDSVGWTADVERISAWLNGLDRETYELVFAAIE FT VLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAGNKA FT GRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG" FT CDS complement(189046..189405) FT /transl_table=11 FT /locus_tag="Rv2023c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2023c, (MTV018.10c), len: 119 aa. Hypothetical FT protein, alternative upstream start possible. TBparse score FT is 0.913" FT /db_xref="UniProtKB/TrEMBL:O53469" FT /protein_id="CAA17237.1" FT /translation="MAARHARAGRWAAQPRPMLGSGAVRYEVGANIDATGFGGIAAVHR FT LVTRLGLVTRLGLVERVDAHSRFSSSNLPKSSRRISGRVSLSGMSNSAAKVVASTSSSP FT WGQPLSVGLRRRWRS" FT CDS complement(189565..190023) FT /pseudo FT /transl_table=11 FT /locus_tag="Rv2023A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2023A, len: 152 aa. Hypothetical unknown protein FT (pseudogene), equivalent to the C-terminus of Q8VJS0|MT2080 FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain FT CDC1551 (225 aa), FASTA scores: opt: 1028, E(): 3.6e-66, FT (99.342% identity in 152 aa overlap) and C-terminus of FT Mb2047c HYPOTHETICAL PROTEIN from Mycobacterium bovis (225 FT aa). And N-terminal part equivalent to the C-terminus of FT Q9XB17 HYPOTHETICAL 15.5 kDa PROTEIN from Mycobacterium FT bovis BCG (131 aa), FASTA scores: opt: 409, E(): 4.2e-22, FT (98.276% identity in 58 aa overlap). Note that a deletion FT of DNA (RvD1 region) in Mycobacterium tuberculosis strain FT H37Rv resulted in a truncated CDS comparatively to FT Mycobacterium bovis or Mycobacterium tuberculosis strain FT CDC1551 genomes (see citations below)." FT /db_xref="PSEUDO:CAE55448.1" FT CDS complement(189990..191537) FT /transl_table=11 FT /locus_tag="Rv2024c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2024c, (MTV018.11c), len: 515 aa. Conserved FT hypothetical protein. Identical to N-terminal part of much FT larger hypothetical protein, RvD1-Rv2024c' (1606 aa), from FT Mycobacterium bovis BCG: FT CAB44655.1|Y18605|13881753|AAK46361.1|AE007059 so probably FT truncated. Part of RvD1 chromosomal deletion region. Also FT similar to hypothetical protein from Helicobacter pylori. FT FASTA scores: AE0005|HPAE000580_2 Helicobacter pylori (607 FT aa) opt: 64, E(): 0, (36.2% identity in 464 aa overlap). FT TBparse score is 0.879" FT /db_xref="GOA:O53470" FT /db_xref="InterPro:IPR014001" FT /db_xref="UniProtKB/TrEMBL:O53470" FT /protein_id="CAA17238.1" FT /translation="MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDAV FT WWWIDWPERRGRTDTGIDLVARERDTGNYTAIQCKFYEPTHTLAKGDIDSFFTASGKTG FT FTNRVIISTTDRWGRNAEDALADQLVPVQRIGMAEIAESPIDWDIAWPADDLQVNLTPA FT KRHELRPHQQQAIDAVFRGFAVGNDRGKLIMACGTGKTFTALKIAERIAADNGGSARIL FT LLVPSISLLSQTLREWTAQSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTDARVLL FT HEMAHRRRAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLAGDDESN FT FVRVHDGQYLKAARRLYMTATPRIFTESIKDRADQHSAELVSMDDELTFGPEFHRLSFG FT EAVERGLLTDYKVMVLTVDQGVIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGT FT GIVAGEPPMRRAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLACLNSSRRIQA" FT CDS complement(192047..193045) FT /transl_table=11 FT /locus_tag="Rv2025c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF METAL FT IONS ACROSS THE MEMBRANE." FT /note="Rv2025c, (MTV018.12c), len: 332 aa. Possible FT conserved transmembrane protein, CDF family possibly FT involved in transport of metal ions, similar to several FT hypothetical bacterial proteins e. g. Methanobacterium FT thermoautotrophicum AE000941_1 (298 aa; described as cation FT efflux system protein) and Archaeoglob us fulgidus FT AE001111_5 (384 aa). FASTA scores: AE000941_1 M FT ethanobacterium thermoautotrophicum (298 aa) opt: 452 E(): FT 3.3e-24; 30.8% identity in 266 aa overlap and AE001111_5 FT Archaeoglobus fulgidus section 16 (384 aa) opt: 371 E(): FT 1.7e-18; 27.7% identity in 267 aa overlap. TBparse score is FT 0.897" FT /db_xref="GOA:O53471" FT /db_xref="InterPro:IPR002524" FT /db_xref="UniProtKB/TrEMBL:O53471" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17239.1" FT /translation="MTHDHAHSRGVPAMIKEIFAPHSHDAADSVDDTLESTAAGIRTVK FT ISLLVLGLTALIQIVIVVMSGSVALAADTIHNFADALTAVPLWIAFALGAKPATRRYTY FT GFGRVEDLAGSFVVAMITMSAIIAGYEAIARLIHPQQIEHVGWVALAGLVGFIGNEWVA FT LYRIRVGHRIGSAALIADGLHARTDGFTSLAVLCSAGGVALGFPLADPIVGLLITAAIL FT AVLRTAARDVFRRLLDGVDPAMVDAAEQALAARPGVQAVRSVRMRWIGHRLHADAELDV FT DPALDLAQAHRIAHDAEHELTHTVPKLTTALIHAYPAEHGSSIPDRGRTVE" FT CDS complement(193160..194044) FT /transl_table=11 FT /locus_tag="Rv2026c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2026c, (MTV018.13c), len: 294 aa. Conserved FT hypothetical protein, very similar to Mycobacterium FT tuberculosis hypothetical proteins Rv2005c, Rv2623, Rv1996, FT Rv2624c, Rv2028c, Rv3134c, Rv1636. Some, possibly all, of FT these belong to universal stress protein family. TBparse FT score is 0.946" FT /db_xref="GOA:O53472" FT /db_xref="InterPro:IPR006015" FT /db_xref="UniProtKB/TrEMBL:O53472" FT /protein_id="CAA17240.1" FT /translation="MSAATAKYGILVGVDGSAQSNAAVAWAAREAVMRQLPITLLHIVA FT PVVVGWPVGQLYANMTEWQKDNAQQVIEQAREALTNSLGESKPPQVHTELVFSNVVPTL FT IDASQQAWLMVVGSQGMGALGRLLLGSISTALLHHARCPVAIIHSGNGATPDSDAPVLV FT GIDGSPASEAATALAFDEASRRRVDLVALHAWTDLGMFPVLGMDWREREKREAEVLAER FT LAGWQEQYPDVRVHRSLVCDKPARWLLEHSEQAQLVVVGSHGRGGFSGMLLGSVSSAVA FT HSVRIPVIVVRPS" FT CDS complement(194084..195805) FT /transl_table=11 FT /locus_tag="Rv2027c" FT /product="Probable histidine kinase response regulator" FT /function="signal transduction" FT /note="Rv2027c, (MTV018.14c), len: 573 aa. Probable FT histidine kinase response regulator, highly similar to FT others e.g. NP_628132.1|NC_003888 putative two component FT sensor from Streptomyces coelicolor (560 aa); FT NP_626695.1|NC_003888 putative two-component sensor FT histidine kinase from Streptomyces coelicolor (475 aa); FT etc. Highly similar to Mycobacterium tuberculosis protein FT Rv3132c, MTCY03A2.2 6. FASTA scores: Z83867|MTCY3A2_26 (578 FT aa) opt: 2330, E(): 0; 62.5% identity in 560 aa overlap. FT TBparse score is 0.903" FT /db_xref="GOA:O53473" FT /db_xref="InterPro:IPR011712" FT /db_xref="PDB:2VZW" FT /db_xref="UniProtKB/TrEMBL:O53473" FT /protein_id="CAA17241.1" FT /translation="MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDR FT LDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEE FT TRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDE FT VFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGT FT QMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAV FT KQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALR FT SADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRL FT FAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLD FT KVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVE FT DDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR" FT CDS complement(195866..196705) FT /transl_table=11 FT /locus_tag="Rv2028c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2028c, (MTV018.15c), len: 279 aa. Conserved FT hypothetical protein, highly similar to Mycobacterium FT tuberculosis proteins Rv2005c, Rv2623, Rv1996, Rv2624c, FT Rv3134c, Rv1636. Some, possibly all, of these belong to FT universal stress protein family. Rv2624c|MTCY01A10.08 (272 FT aa) and Rv3134c|MTCY03A2.24 (268 aa). FASTA scores: FT Z95387|MTCY1A10_8 (272 aa) opt: 563, E(): 2.5e-31, (36.8% FT identity in 266 aa overlap) and Z83867|MTCY3A2_24 (268 aa) FT opt: 562, E(): 2.9e-31, (40.7% identity in 273 aa overlap). FT TBparse score is 0.904" FT /db_xref="GOA:O53474" FT /db_xref="InterPro:IPR006015" FT /db_xref="UniProtKB/TrEMBL:O53474" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17242.1" FT /translation="MNQSHKPPSIVVGIDGSKPAVQAALWAVDEAASRDIPLRLLYAIE FT PDDPGYAAHGAAARKLAAAENAVRYAFTAVEAADRPVKVEVEITQERPVTSLIRASAAA FT ALVCVGAIGVHHFRPERVGSTAAALALSAQCPVAIVRPHRVPIGRDAAWIVVEADGSSD FT IGVLLGAVMAEARLRDSPVRVVTCRQSGVGDTGDDVRASLDRWLARWQPRYPDVRVQSA FT AVHGELLDYLAGLGRSVHMVVLSASDQEHVEQLVGAPGNAVLQEAGCTLLVVGQQYL" FT CDS complement(196702..197721) FT /transl_table=11 FT /gene="pfkB" FT /locus_tag="Rv2029c" FT /product="Probable phosphofructokinase PfkB FT (PHOSPHOHEXOKINASE)" FT /function="Involved in glycolysis: converts sugar-1-P to FT sugar-1,6-P." FT /EC_number="2.7.1.-" FT /note="Rv2029c, (MTV018.16c), len: 339 aa. Probable pfkB, FT phosphofructokinase (EC 2.7.1.-), similar to others eg FT P06999|K6P2_ECOLI 6-PHOSPHOFRUCTOKINASE I SOZYME 2 from E. FT coli (309 aa), FASTA scores: opt: 705, E(): 0; (41.4% FT identity in 304 aa overlap); and LACC_STRMU FT phosphotagatosekinase (310 aa); etc. Contains PS00583 pfkB FT family of carbohydrate kinases signature 1. TBparse score FT is 0.927." FT /db_xref="GOA:O86352" FT /db_xref="InterPro:IPR017583" FT /db_xref="UniProtKB/TrEMBL:O86352" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17243.1" FT /translation="MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPRY FT DPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIPIAASTRESFT FT VNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVASGSLPPGVAADYYQRV FT ADICRRSSTPLILDTSGGGLQHISSGVFLLKASVRELRECVGSELLTEPEQLAAAHELI FT DRGRAEVVVVSLGSQGALLATRHASHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSL FT IKSVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP" FT misc_feature complement(197506..197580) FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1" FT CDS complement(197738..199783) FT /transl_table=11 FT /locus_tag="Rv2030c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2030c, (MTV018.17c), len: 681 aa. Conserved FT hypothetical protein that corresponds to products of two FT adjacent ORF's described previously MSGTUBDWN_4 (390 aa) FT and MSGTUBDWN_1 (385 aa). Also similar to C-terminal FT two-thirds of Mycobacterium tuberculosis protein Rv2143 FT (MTCY270.25c; 352 aa) and to Rv0571c (443 aa) and M. leprae FT protein U650s MLU15184_16 (258 aa). FASTA scores: FT M93129|MSGTUBDWN_4 (390 aa) opt: 2530 E(): 0; 97.7% FT identity in 385 aa overlap and M93129|MSGTUBDWN_1 (385 aa) FT opt: 1983 E(): 0; 99.0% identity in 309 aa overlap. Z95388| FT MTCY270_25 (352 aa) opt: 882 E(): 0; 61.1 % identity in 226 FT aa overlap. U15184|MLU15184_16 (258 aa) opt: 549 E(): FT 9.8e-29; 43.8% identity in 219 aa overlap. TBparse score is FT 0.907" FT /db_xref="GOA:O53475" FT /db_xref="InterPro:IPR007815" FT /db_xref="UniProtKB/TrEMBL:O53475" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17244.1" FT /translation="MLMTAAADVTRRSPRRVFRDRREAGRVLAELLAAYRDQPDVIVLG FT LARGGLPVAWEVAAALHAPLDAFVVRKLGAPGHDEFAVGALASGGRVVVNDDVVRGLRI FT TPQQLRDIAEREGRELLRRESAYRGERPPTDITGKTVIVVDDGLATGASMFAAVQALRD FT AQPAQIVIAVPAAPESTCREFAGLVDDVVCATMPTPFLAVGESFWDFRQVTDEEVRRLL FT ATPTAGPSLRRPAASTAADVLRRVAIDAPGGVPTHEVLAELVGDARIVLIGESSHGTHE FT FYQARAAMTQWLIEEKGFGAVAAEADWPDAYRVNRYVRGLGEDTNADEALSGFERFPAW FT MWRNTVVRDFVEWLRTRNQRYESGALRQAGFYGLDLYSLHRSIQEVISYLDKVDPRAAA FT RARARYACFDHACADDGQAYGFAAAFGAGPSCEREAVEQLVDVQRNALAYARQDGLLAE FT DELFYAQQNAQTVRDAEVYYRAMFSGRVTSWNLRDQHMAQTLGSLLTHLDRHLDAPPAR FT IVVWAHNSHVGDARATEVWADGQLTLGQIVRERYGDESRSIGFSTYTGTVTAASEWGGI FT AQRKAVRPALHGSVEELFHQTADSFLVSARLSRDAEAPLDVVRLGRAIGVVYLPATERQ FT SHYLHVRPADQFDAMIHIDQTRALEPLEVTSRWIAGENPETYPTGL" FT CDS complement(199795..200229) FT /transl_table=11 FT /gene="hspX" FT /locus_tag="Rv2031c" FT /standard_name="acr" FT /product="HEAT SHOCK PROTEIN HSPX (ALPHA-CRSTALLIN HOMOLOG) FT (14 kDa ANTIGEN) (HSP16.3)" FT /function="STRESS PROTEIN INDUCED BY ANOXIA. HAS A PROPOSED FT ROLE IN MAINTENANCE OF LONG-TERM VIABILITY DURING LATENT, FT ASYMPTOMATIC INFECTIONS, AND A PROPOSED ROLE IN REPLICATION FT DURING INITIAL INFECTION. REGULATED BY THE TWO COMPONENT FT REGULATORY SYSTEM DEVR|Rv3133c/DEVS|Rv3132c, IN RESPONSE TO FT A HYPOXIC SIGNAL." FT /note="Rv2031c, (MTV018.18c), len: 144 aa. hspX, heat shock FT protein localized in the inner membrane (see citations FT below). Identical to P30223|14KD_MYCTU 14 KD ANTIGEN (16 FT kDa ANTIGEN) (HSP 16.3) of Mycobacterium tuberculosis (143 FT aa), FASTA scores: opt: 933, E(): 0, (100.0% identity in FT 143 aa overlap). BELONGS TO THE SMALL HEAT SHOCK PROTEIN FT (HSP20) FAMILY. Also known as alpha-crystallin and gene as FT acr (see some citations below). TBparse score is 0.897." FT /db_xref="GOA:P0A5B7" FT /db_xref="InterPro:IPR002068" FT /db_xref="UniProtKB/Swiss-Prot:P0A5B7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17245.1" FT /translation="MATTLPVQRHPRSLFPEFSELFAAFPSFAGLRPTFDTRLMRLEDE FT MKEGRYEVRAELPGVDPDKDVDIMVRDGQLTIKAERTEQKDFDGRSEFAYGSFVRTVSL FT PVGADEDDIKATYDKGILTVSVAVSEGKPTEKHIQIRSTN" FT CDS 200426..201421 FT /transl_table=11 FT /gene="acg" FT /locus_tag="Rv2032" FT /product="Conserved hypothetical protein Acg" FT /function="Unknown. May have a role for bacteria within the FT host environment." FT /note="Rv2032, (MTV018.19), len: 331 aa. acg (for FT acr-coregulated gene), conserved hypothetical protein FT possibly member of a superfamily of classical FT nitroreductases (see Purkayastha et al., 2002), similar to FT hypothetical mycobacterial proteins Rv3127|MTCY164.37 (344 FT aa) and Rv3131|MTCY03A2.27c (332 aa). FASTA scores: FT Z95150|MTCY164_38 Mycobacterium tuberculosis cosmid (344 FT aa) opt: 1208, E(): 0, (56.4% identity in 321 aa overlap); FT Z83867| MTCY3A2_27 Mycobacterium tuberculosis cosmid (332 FT aa) opt: 568, E(): 8.6e-30, (36.8% identity in 321 aa FT overlap). Similar to proteins SCJ1.11 (330 aa; AL109962) FT and SCJ12.27c (335 aa; AL109989) in Streptomyces FT coelicolor. TBparse score is 0.931." FT /db_xref="GOA:O53476" FT /db_xref="InterPro:IPR000415" FT /db_xref="UniProtKB/TrEMBL:O53476" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17246.1" FT /translation="MPDTMVTTDVIKSAVQLACRAPSLHNSQPWRWIAEDHTVALFLDK FT DRVLYATDHSGREALLGCGAVLDHFRVAMAAAGTTANVERFPNPNDPLHLASIDFSPAD FT FVTEGHRLRADAILLRRTDRLPFAEPPDWDLVESQLRTTVTADTVRIDVIADDMRPELA FT AASKLTESLRLYDSSYHAELFWWTGAFETSEGIPHSSLVSAAESDRVTFGRDFPVVANT FT DRRPEFGHDRSKVLVLSTYDNERASLLRCGEMLSAVLLDATMAGLATCTLTHITELHAS FT RDLVAALIGQPATPQALVRVGLAPEMEEPPPATPRRPIDEVFHVRAKDHR" FT CDS complement(201537..202379) FT /transl_table=11 FT /locus_tag="Rv2033c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2033c, (MTV018.20), len: 280 aa. Conserved FT hypothetical protein, similar to hypothetical protein FT SCC77.24 (274 aa) from Streptomyces coelicolor A3(2) FT CAB66235.1|AL13650) (50% identity in 261 aa overlap). FT TBparse score is 0.897" FT /db_xref="UniProtKB/TrEMBL:O53477" FT /protein_id="CAA17247.1" FT /translation="MLDRYGTDVLAAGGRRRPRSVEHPVELGMVVEDAETGYVGAVVRV FT EYGRIDLEDRYGKTRGFPLGPGYLLDGLPVILTAPRCAAAAGPRRTASGSVAVPGARAR FT VARASRIYVEGRHDAELIAAVWGADLRIEGVVVEHLGGVDDLVEIVAKFRPGPRRRLGV FT LVDHLVAGSKEARIAEVVRRGPGGSDTLVVGHPYVDIWQAVKPQRVGLAAWPRVPRHIE FT WKHGVCDALGWPHADQADIAAAWRRIRSQVRDWTDLEPALIGRVEELIDFVTQPAGDE" FT CDS 202591..202914 FT /transl_table=11 FT /locus_tag="Rv2034" FT /product="Probable ArsR-type repressor protein" FT /function="Involved in transcriptional regulation." FT /note="Rv2034, (MTV018.21), len: 107 aa. Probable repressor FT protein similar to several belonging to the ARSR FAMILY FT e.g. Q53040 (112 aa). FASTA scores: sptr|Q53040|Q53040 FT NITRILE HYDRATASE REGULATAR 2 (112 aa) opt: 167, E( ): FT 6.7e-06; 44.7% identity in 76 aa overlap. TBparse score is FT 0.905. Contains probable helix-turn-helix at aa 32-53 (S FT core 1350, +3.78 SD)" FT /db_xref="GOA:O53478" FT /db_xref="HSSP:1SMT" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:O53478" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17248.1" FT /translation="MSTYRSPDRAWQALADGTRRAIVERLAHGPLAVGELARDLPVSRP FT AVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAALRTDLDRFWTRALTGYAQLIDSEG FT DDT" FT CDS 202911..203399 FT /transl_table=11 FT /locus_tag="Rv2035" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2035, (MTV018.22), len: 162 aa. Conserved FT hypothetical protein, similar to conserved hypothetical FT protein (156 aa) from Sinorhizobium meliloti FT CAC46569.1|AL591789 (34% identity in 146 aa overlap). FT TBparse score is 0.925" FT /db_xref="GOA:O53479" FT /db_xref="InterPro:IPR013538" FT /db_xref="UniProtKB/TrEMBL:O53479" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17249.1" FT /translation="MTRPRTDAIHHHVVVNAPIERAFAVFTTRFGDFKPREHNLLAIPI FT TETVFECHAGGHIYDRGVDGSVCKWARVLVYEPPSRVLFTWDIGPTWRPETDLAKTSEV FT EVRFTAQSAETTRVDLEHRHLDRHGPGWESVADGVDSEAGWPLYLRRYTDLLCIQVQP" FT CDS 203396..204037 FT /transl_table=11 FT /locus_tag="Rv2036" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2036, (MTV018.23), len: 213 aa. Conserved FT hypothetical protein; slight similarity to Streptomyces FT lincolnensis protein involved in lincomycin production FT Q54375 (238 aa). FASTA scores: sptr|Q54375|Q54375 (78-11) FT LINCOMYCIN PRODUCTION GENES (238 aa) opt: 119, E(): 0.97; FT 31.3% identity in 99 aa overlap. TBparse score is 0.934" FT /db_xref="InterPro:IPR017517" FT /db_xref="UniProtKB/TrEMBL:O53480" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17250.1" FT /translation="MIAADDDTEKSMMDMARAERAELAAFLTTLTLQQWETPSLCAGWS FT VKEVVAHMISYEDLGVFGLLKRFAKGRIVRANEVGVDEFAGLSPQELADYVGRHLQPRG FT LTAGFGGMIALVDGMIHHQDIRRPLGQPRTIPAQRLDRVLRLMPKNPRLRARPRIKGLR FT LRATDLDWTIGTGPEVTGPGEALLMAMAGRPAAVSDLSGPGKPTLAGRLG" FT CDS complement(204044..205018) FT /transl_table=11 FT /locus_tag="Rv2037c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2037c, (MTV018.24c), len: 324 aa. Possible FT conserved transmembrane protein, similar to hypothetical FT proteins from Mycobacterium leprae MLCB2052.31 (329 aa) and FT Bacillus subtilis P54513|YQHO_BACSU (291 aa). FASTA scores: FT Z98604|MLCB2052_1 6 Mycobacterium leprae cosmid B205 (329 FT aa) opt: 1764, E(): 0; 80.5% identity in 323 aa overlap and FT sp|P54513|YQHO_BACSU HYPOTHETICAL 32.9 KD PROTEIN IN G (291 FT aa ) opt: 328, E(): 8.8e-14; 36.6% identity in 306 aa FT overlap. TBparse score is 0.919" FT /db_xref="GOA:O53481" FT /db_xref="InterPro:IPR002641" FT /db_xref="UniProtKB/TrEMBL:O53481" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17251.1" FT /translation="MALVSTARVDLVCEGGGVRGIGLVGAVDALADAGYRFPRVAGSSA FT GAIVASLVAALQTAGEPVTRLAEMMRSIDYPKFLDRNLIGHVPLIGGGLSLLLSDGVYR FT GAYLEQLLGGLLADLGVHTFGDLRTGEAPEQFAWSLVVTASDLSRRRLVRIPWDLDSYG FT IHPDDFSVARAVHASSAIPFVFEPVRVRGATWVDGGLLSNFPVALFDRTDAEPRWPTFG FT IRLSARPGIPPTRPVQGPVSLGIAAIETLVSNQDNAYIDDPCTVRRTIFVPAHDVSPID FT FDITAEQREALYQRGFQAGQKFLANWNYADCLADCGGPFTPSL" FT CDS complement(205020..206093) FT /transl_table=11 FT /locus_tag="Rv2038c" FT /product="Probable sugar-transport ATP-binding protein ABC FT transporter" FT /function="Thought to be involved in active transport of FT sugar across the membrane (import). Responsible for energy FT coupling to the transport system." FT /note="Rv2038c, (MTV018.25c), len: 357 aa. Probable FT sugar-transport ATP-binding protein ABC transporter (see FT citation below), equivalent to FT MLCB2052.30|Z98604|MLCB2052_15 from Mycobacterium leprae FT (356 aa), FASTA scores: opt: 1866, E(): 0, (79.7% identity FT in 355 aa overlap). Also similar to multiple sugar import FT proteins e.g. Y08921|SRMSIK_1 msiK protein from FT Streptomyces reticuli (377 aa), FASTA scores: opt: 1336, FT E(): 0, (62.6% identity in 377 aa overlap); etc. Also FT similar to several proteins from Mycobacterium tuberculosis FT e.g. Rv2832c, Rv1238, Rv2397c, Rv3758c. Contains PS00211 FT ABC transporters family signature and PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). FT TBparse score is 0.923." FT /db_xref="GOA:O53482" FT /db_xref="HSSP:1G29" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:O53482" FT /protein_id="CAA17252.1" FT /translation="MASVSFEQATRRYPGTDRPALDRLDLIVGDGEFVVLVGPSGCGKT FT TSLRMVAGLETLDCGRIRIGERDVTEVDPKDRDVAMVFQNYALYPHMTVAQNMGFALKV FT AKIGKAEIRERVLAAAKLLDLQSYLDRKPKDLSGGQRQRVAMGRAIVRRPQVFLMDEPL FT SNLDAKLRGQTRNQIAALQRQLGTTTVYVTHDQVEAMTMGDRVAVLSDGVLQQCASPRE FT LYRNPGNVFVAGFIGSPAMNLFRLSIADSTVSLGDWQILLPRAVVGTAAEVIIGVRPEH FT LELGGAGIEMDVDMVEELGADAYLYGRIVSGGCEMDQSIVARVDGRGPPERGSRVRLCP FT TPGHLHFFAVDGRRIPG" FT misc_feature complement(205644..205688) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(205959..205982) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(206096..206938) FT /transl_table=11 FT /locus_tag="Rv2039c" FT /product="Probable sugar-transport integral membrane FT protein ABC transporter" FT /function="Thought to be involved in active transport of FT sugar across the membrane (import). Responsible for the FT translocation of the substrate across the membrane." FT /note="Rv2039c, (MTV018.26c), len: 280 aa. Probable FT sugar-transport integral membrane protein ABC transporter FT (see citation below), equivalent to FT MLCB2052.29|Z98604|MLCB2052_14 from Mycobacterium leprae FT (283 aa), FASTA scores: opt: 1593, E(): 0, (79.2% identity FT in 283 aa overlap). Also similar to maltose and lactose FT transport proteins e.g. X66092|CPMALGHOM_1 from C. FT perfringens (275 aa), FASTA scores: opt: 695, E(): 0, FT (41.2% identity in 228 aa overlap); etc. Contains PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp signature. Also contains possible helix-turn-helix FT motif at aa 171-192, although this is probably fortuitous. FT TBparse score is 0.912." FT /db_xref="GOA:O53483" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:O53483" FT /protein_id="CAA17253.1" FT /translation="MGWADRIVHRHFIRGLALYAGLIGIAWCALFPIIWALSGSLKADG FT EVTEPTLFPSHPQWSNYREVFALMPFWRMFFNTVLYAGCVTAGQVFFCSLAGYAFARLQ FT FRGRDTLFVLYLSTLMVPLTVTVIPQVILMRIVGWVDTPWAMIVPGLFGSAFGTYLMRQ FT FFRTLPTDLEEAAILDGCSPWQIYWRILLPHSRPAVLVLGVLTWVNVWNDFLWPLLMIQ FT RNSLATLTLGLVRLRGEYVARWPVLMAASMLMLVPLVILYAVAQRSFVRGIAVTGLGG" FT misc_feature complement(206360..206446) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp signature." FT CDS complement(206925..207827) FT /transl_table=11 FT /locus_tag="Rv2040c" FT /product="Probable sugar-transport integral membrane FT protein ABC transporter" FT /function="Thought to be involved in active transport of FT sugar across the membrane (import). Responsible for the FT translocation of the substrate across the membrane." FT /note="Rv2040c, (MTV018.27c), len: 300 aa. Probable FT sugar-transport integral membrane protein ABC transporter FT (see citation below), equivalent to FT MLCB2052.28|Z98604|MLCB2052_13 from Mycobacterium leprae FT (319 aa), FASTA scores: opt: 1606, E(): 0, (81.6% identity FT in 293 aa overlap). Also similar to many diverse sugar FT transport proteins. TBparse score is 0.934." FT /db_xref="GOA:O53484" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:O53484" FT /protein_id="CAA17254.1" FT /translation="MTRRRGRRAWAGRMFVAPNLAAVVVFMLFPLGFSLYMSFQKWDLF FT THATFVRLDNFRNLFTSDPLFLIAVVNTAVYTVGTVVPTVIVSLVVAAFLNRKIKGISL FT FRTVVFLPLAISSVVMAVVWQFVFNTDNGLLNIMLGWLGIGPIPWLIEPRWAMVSLCLV FT SVWRSVPFATVVLLAAMQGVPETVYEAARIDGAGEIRQFVSITVPLIRGALSFVVVISI FT IHAFQAFDLVYVLTGANGGPETATYVLGIMLFQHAFSFLEFGYASALAWVMFAILLVLT FT VLQLRITHRRSWEASRGLG" FT misc_feature complement(207204..207290) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp sign." FT CDS complement(207824..209143) FT /transl_table=11 FT /locus_tag="Rv2041c" FT /product="Probable sugar-binding lipoprotein" FT /function="Thought to be involved in active transport of FT sugar across the membrane (import)." FT /note="Rv2041c, (MTV018.28c), len: 439 aa. Probable FT sugar-binding lipoprotein component of sugar transport FT system, equivalent to Z98604|MLCB2052_1|MLCB2052.27 from FT Mycobacterium leprae (445 aa), FASTA scores: opt: 2324, FT E(): 0, (77.4% identity in 446 aa overlap). Contains signal FT sequence and appropriately positioned PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site. TBparse score FT is 0.927." FT /db_xref="GOA:O53485" FT /db_xref="InterPro:IPR019546" FT /db_xref="UniProtKB/TrEMBL:O53485" FT /protein_id="CAA17255.1" FT /translation="MVNKPFERRSLLRGAGALTAASLAPWAAGCAADDDDALTFFFAAN FT PDELRPRMRVVNEFQRRYPDIKVRALLSGPGVMQQLATFCAGGKCPDVLMAWELTYAEL FT ADRGVLLDLNTLLARDQAFAAELKSDSIGALYETFTFNGGQYAFPEQWSGNFLFYNKQL FT FDDAGVPPPPGSWERPWSFAEFLDAAQALTKQGRSGRDRQWGFVNAWVSFYAAGLFAMN FT NGVPWSVPRMNPTHLNFDHDGFLEAVQFYADLTNKHKVAPSAAEQQSMSTADLFSVGKA FT GIALAGHWRYQTFDRADGLDFDVAPLPIGPRGRAACSDIGVTGLAIAATSRRKDQAWEF FT VKFATGPVGQALIGESRLFVPVLRSAINSHGFANAHRRVGNLAVLSEGPAYSEGLPVTP FT AWEKIAALMDRYFGPVLRGSRPATSLTGLSQAVDEVLRNP" FT misc_feature complement(209054..209086) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(209181..209978) FT /transl_table=11 FT /locus_tag="Rv2042c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2042c, (MTV018.29c), len: 265 aa. Conserved FT hypothetical protein,similar in N-terminal part to FT hypothetical proteins MLCB2052.24 (95 aa) and FT Rv0760c|MTCY369.05 (139 aa). FASTA scores: FT Z98604|MLCB2052_9 Mycobacterium leprae cosmid B2052 (95 aa) FT opt: 269, E(): 2.9e-12, (55.4% identity in 92 aa overlap) FT and Z80226|MTCY369_5 Mycobacterium tuberculosis cosmid (139 FT aa) opt: 150, E(): 0.001, (28.7% identity in 136 aa FT overlap). TBparse score is 0.909" FT /db_xref="GOA:O53486" FT /db_xref="HSSP:1OCV" FT /db_xref="InterPro:IPR002075" FT /db_xref="UniProtKB/TrEMBL:O53486" FT /protein_id="CAA17256.1" FT /translation="MAPPNRDELLAAVERSPQAAAAHDRAGWVGLFTGDARVEDPVGSQ FT PQVGHEAIGRFYDTFIGPRDITFHRDLDIVSGTVVLRDLELEVAMDSAVTVFIPAFLRY FT DLRPVTGEWQIAALRAYWELPAMMLQFLRTGSGATRPALQLSRALLGNQGLGGTAGFLT FT GFRRAGRRHKKLVETFLNAASRADKSAAYHALSRTATMTLGEDELLDIVELFEQLRGAS FT WTKVTGAGSTVAVSLASDHRRGIMFADVPWRGNRINRIRYFPA" FT CDS complement(209978..210538) FT /transl_table=11 FT /gene="pncA" FT /locus_tag="Rv2043c" FT /product="PYRAZINAMIDASE/NICOTINAMIDAS PNCA (PZase)" FT /function="Converts amides such as nicotinamide to FT corresponding acid." FT /EC_number="3.5.1.-" FT /note="Rv2043c, (MTV018.30c), len: 186 aa. pncA, FT pyrazinamidase/nicotinamidase (EC 3.5.1.-) (see citations FT below). Identical to PYRAZINAMIDASE/NICOTINAMIDASE involved FT in susceptibility or resistance to antituberculous drug FT pyrazinamide. FASTA scores: sptr|Q50575|Q50575 FT PYRAZINAMIDASE/NICOTINAMIDASE. (186 aa) opt: 1236, E(): 0; FT 100.0% identity in 186 aa overlap. TBparse score is 0.892." FT /db_xref="GOA:Q50575" FT /db_xref="HSSP:1ILW" FT /db_xref="InterPro:IPR000868" FT /db_xref="UniProtKB/TrEMBL:Q50575" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17257.1" FT /translation="MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVV FT ATKDFHIDPGDHFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYS FT GFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLTAGV FT SADTTVAALEEMRTASVELVCSS" FT CDS complement(210579..210896) FT /transl_table=11 FT /locus_tag="Rv2044c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2044c, (MTV018.31c), len: 105 aa. Conserved FT hypothetical protein, similar to conserved hypothetical FT protein PA3386 (121 aa) from Pseudomonas aeruginosa |E83221 FT conserved hypothetical protein PA3386 [imported] - FT Pseudomonas aeruginosa (strain PAO1) FT 9949522|gb|AAG06774.1|AE004760_2 (AE004760). (46% identity FT in 92 aa overlap). TBparse score is 0.914" FT /db_xref="UniProtKB/TrEMBL:O53487" FT /protein_id="CAA17258.1" FT /translation="MHFAFIAYVLAGGFLALRWRRTMWLHVPAVIWGIGIAAKRVDCPL FT TWVERWARTKAAMTPLSPDGFVAHYITGVIYPAGWVAAAQLVMFAIVAASWTLYLWLPR FT R" FT CDS complement(210982..212517) FT /transl_table=11 FT /gene="lipT" FT /locus_tag="Rv2045c" FT /product="Probable carboxylesterase LipT" FT /function="Converts unknown esters to corresponding free FT acid and alcohol" FT /EC_number="3.1.1.-" FT /note="Rv2045c, (MTV018.32c), len: 511 aa. Probable lipT, FT carboxylesterase similar to many e.g. O08472 (489 aa) and FT P37967|PNBA_ BACSU (489 aa). PARA-NITROBENZYL ESTERASE (EC FT 3.1.1.-). Contains PS00941 Carboxylesterases type-B FT signature 2. Contains PS00122 Carboxylesterases type-B FT serine active site. FASTA scores: sptr|O08472|O08472 FT INTRACELLULAR ESTERASE B (489 aa) opt: 849, E(): 0, (36.2% FT identity in 489 aa overlap) and sp|P37967|PNBA_BACSU FT PARA-NITROBENZYL ESTERASE (489 aa) opt: 838, E(): 0, (36.0% FT identity in 489 aa overlap). TBparse score is 0 .918" FT /db_xref="GOA:O53488" FT /db_xref="HSSP:1QE3" FT /db_xref="InterPro:IPR019826" FT /db_xref="UniProtKB/TrEMBL:O53488" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17259.1" FT /translation="MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARAP FT VGSLRFRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPEE FT PATQPLPVMVFIHGGGYILGSSATPIYDGAALARRGCVYVSVNYRLGALGCLDLSSLST FT PQITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPAAKGL FT FARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQASPAQLVEAQHHLIR FT QGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTRFLGMLP FT TNEPMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAP FT TYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALRVSNEVQR FT RWRCFSQIGVPGDDWPAYTQDDRAVLVFDRRCRIEFDPHQHRRIAWDGFSLAN" FT misc_feature complement(211900..211947) FT /note="PS00122 Carboxylesterases type-B serine active site" FT misc_feature complement(212212..212244) FT /note="PS00941 Carboxylesterases type-B signature 2" FT CDS 212566..213222 FT /transl_table=11 FT /gene="lppI" FT /locus_tag="Rv2046" FT /product="Probable lipoprotein lppI" FT /function="UNKNOWN" FT /note="Rv2046, (MTV018.33), len: 218 aa. Probable lppI, FT lipoprotein contains signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site. TBparse score is 0.898" FT /db_xref="UniProtKB/TrEMBL:O53489" FT /protein_id="CAA17260.1" FT /translation="MRIAALVAVSLLIAGCSREVGGDVGQSQTIAPPAPAPSAAPSTPP FT AAGAPITTIVSWIEAGHPVDPAAYHVATRDGVTTQLGDDVAFSASSGTVACMTDARHTS FT GTLACLVRLANPPPRPETAYGEWKGGWVDFDGIHLQVGSARADPGPFVYGNGPELANGD FT TLSIGDYRCRSYQAGLFCVNYAHQSAVRFASAGIEPFGCLKPAPPPDGVGVAFGC" FT misc_feature 212581..212613 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(213259..215823) FT /transl_table=11 FT /locus_tag="Rv2047c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2047c, (MTV018.34c), len: 854 aa. Conserved FT hypothetical protein, similar to hypothetical protein from FT Mycobacterium tuberculosis Rv1868|MTCY359.05c (699 aa) and FT three possible pseudogene fragments from Mycobacterium FT leprae MLCB2052.16 (251 aa), MLCB2052.17 (120 aa), FT MLCB2052.18 (257 aa). FASTA scores: gp|Z98604|MLCB2052_7 FT (257 aa) opt: 1248, E(): 0, (78.6% identity in 248 aa FT overlap); and Z98604|MLCB2052_5 (251 aa) opt: 674, E(): 0, FT (50.0% identity in 250 aa overlap); and Z98604|MLCB2052_6 FT (120 aa) opt: 608 E() : 3.6e-30, (84.0% identity in 106 aa FT overlap); and Rv1868 Z83859|MTCY359_5 (699 aa) opt: 521 FT E(): 3e-24; (33.0% identity in 730 aa overlap). TBparse FT score is 0.917" FT /db_xref="GOA:P65684" FT /db_xref="InterPro:IPR008279" FT /db_xref="UniProtKB/Swiss-Prot:P65684" FT /protein_id="CAA17261.1" FT /translation="MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFI FT AADIRDATAVESAMTGADVVAHCAWVRGRNDHINIDGTANVLKAMAETGTGRIVFTSSG FT HQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDA FT QRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAELELL FT HSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPA FT VDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGL FT RAGGVGIAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNS FT GFFGPSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVAD FT VDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRD FT TAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEAPEFHSAVLAE FT LTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAPQPPTPVIPLRAKPVALLAA FT RQLRDREVRRDRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVS FT GLVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIV FT RPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDA FT QGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR" FT CDS complement(215828..228283) FT /transl_table=11 FT /gene="pks12" FT /locus_tag="Rv2048c" FT /product="Probable polyketide synthase pks12" FT /function="Involved in polyketide synthesis (product FT unknown)." FT /note="Rv2048c, (MTV018.35c), len: 4151 aa. Probable pks12, FT polyketide synthase similar to many polyketide synthases FT e.g. the second and third modules of polyketide synthase FT from S. erythraea (3567 aa), many other Streptomyces FT enzymes and putative Mycobacterium tuberculosis polyketide FT synthases, e.g. Z85982|MTCY06H11.26 (2126 aa), FASTA FT scores: opt: 6668, E(): 0 (61.2% identity in 2058 aa FT overlap); and Q03132|ERY2_SACER ERYTHRONOLIDE SYNTHASE, FT MODULES 3 from S. erythraea (3567 aa), FASTA scores: opt: FT 5309, E(): 0, (40.5% identity in 4141 aa overlap). Contains FT 2x PS00012 Phosphopantetheine attachment site, 2x PS00606 FT Beta-ketoacyl synthases active site, and PS00343 FT Gram-positive cocci surface proteins 'anchor ing' FT hexapeptide. TB parse score is 0.902." FT /db_xref="GOA:O53490" FT /db_xref="HSSP:1PQW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O53490" FT /protein_id="CAA17262.1" FT /translation="MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCR FT FPGGVDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVA FT DFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG FT MLAEEIEGYRLTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGEC FT DLALAGGVTVNATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDA FT RRLGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGT FT GTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHE FT LLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAV FT PVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVF FT EHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIEL FT LDTAPAFAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAEL FT WKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACG FT ADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASH FT SVEVEAIRGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQA FT VRNACEQGYRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSA FT ASAFVAGVAVNWRGTLDGAGYVELPTYAFDKRRFWLSAEGSGADVSGLGLGASEHPLLG FT AVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDE FT LTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEP FT GADLSVWPPAGAVTVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAG FT GVGGFGVHPALLDAVLHAVVIAGDPDELALPFAWQGVSLHATGASAVRARIAPAGPSAV FT SVELADGLGLPVLSVASMVARPVTERQLLAAVSGSGPDRLFEVIWSPASAATSPGPTPA FT YQIFESVAADQDPVAGSYVRSHQALAAVQSWLTDHESGVLVVATRGAMALPREDVADLA FT GAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGS FT RAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRDI FT MITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPM FT PADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEV FT FATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASL FT RLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG FT VLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGSWAAGTVLITGGTGMAGSAVAR FT HVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIP FT VQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSS FT MAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLAR FT LGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASAPTR FT RQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQ FT DLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGLPQEIKHTPAV FT RTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDA FT AGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALERAGIDPTGLR FT GSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSS FT SLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFAAAADGT FT GFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALA FT NAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQA FT AAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTRRAGV FT SSFGISGTNAHVIIEAVPVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVRGDD FT GLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTV FT FVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENLLNSTE FT FAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGRL FT MQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNAVAAVADQLRADG FT RRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQLAGDDFGSAAYW FT RRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTTMSALRKDRPE FT PATLTNAVAQGFVTGMDLDWRAVVGEAQFVELPTYAFQRRRFWLSGDGVAADAAGLGLA FT ASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGFVELAIRAGDE FT VGCGVVDESTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRGDVGTGWVLHAEGA FT LRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMWRRGDEVFAE FT VALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGVSLHAAGAS FT AVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGPDRLFEVTW FT SPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVLQSWLTRDG FT AGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLDDSALAAV FT VTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRLELIPDA FT DAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGD FT RVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQRV FT LIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFR FT AATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAF FT DLFEPGPDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLM FT PGSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAG FT AQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSK FT VDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAI FT SLGWGLWDQASAMTGGLATVDFKRFARDGIVAMSSADALQLFDTAMIVDEPFMLPAHID FT FAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAVLL FT DLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEMRNRLKSATGLALSPTLIFDYP FT NSAALAGYMRRELLGSSPQDTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALANET FT ETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE" FT misc_feature complement(216164..216211) FT /note="PS00012 Phosphopantetheine attachment site" FT misc_feature complement(221585..221635) FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature complement(222260..222307) FT /note="PS00012 Phosphopantetheine attachment site" FT misc_feature complement(225275..225292) FT /note="PS00343 Gram-positive cocci surface proteins FT 'anchoring' hexapeptide" FT misc_feature complement(227654..227706) FT /note="PS00606 Beta-ketoacyl synthases active site" FT CDS complement(228590..228814) FT /transl_table=11 FT /locus_tag="Rv2049c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2049c, (MTV018.36c), len: 74 aa. Hypothetical FT protein. TBparse score is 0.867" FT /db_xref="UniProtKB/TrEMBL:O53491" FT /protein_id="CAA17263.1" FT /translation="MLTRGEVRALPADAVVLSADDAADLSDRVYQVRCAAEDVVTALDE FT GAAATELRDLCDELIRAARAADGWRRAGA" FT CDS 229118..229453 FT /transl_table=11 FT /locus_tag="Rv2050" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2050, (MTV018.37), len: 111 aa. Conserved FT hypothetical protein, similar to hypothetical proteins from FT Mycobacterium leprae, MLCB2052.03c (113 aa), and FT Streptomyces coelicolor A3(2), SC6D7.18c (124 aa). FASTA FT scores: Z98604|MLCB2052_3 Mycobacterium leprae cosmid B2052 FT (113 aa) opt: 737, E(): 0, (97.3% identity in 111 aa FT overlap) and (55% identity in 85 aa overlap) with FT emb|CAB61670.1|AL133213 hypothetical protein SC6D7.18c. FT TBparse score is 0.884" FT /db_xref="UniProtKB/TrEMBL:O53492" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17264.1" FT /translation="MADRVLRGSRLGAVSYETDRNHDLAPRQIARYRTDNGEEFEVPFA FT DDAEIPGTWLCRNGMEGTLIEGDLPEPKKVKPPRTHWDMLLERRSIEELEELLKERLEL FT IRSRRRG" FT CDS complement(229428..232052) FT /transl_table=11 FT /gene="ppm1" FT /locus_tag="Rv2051c" FT /product="Polyprenol-monophosphomannose synthase Ppm1" FT /function="Transfers mannose from GDP-Mannose to all FT endogenous polyprenol-phosphates." FT /note="Rv2051c, (MTV018.38c), len: 874 aa. ppm1, FT Polyprenol-monophosphomannose synthase. Transfers mannose FT from GDP-Mannose to all endogenous polyprenol-phosphates in FT Mycobacterium tuberculosis, proven experimentally (A. FT Baulard, Institut Pasteur de Lille: see citation below). FT Very similar to polyprenol-phosphate-mannose synthases from FT Mycobacterium smegmatis (594 aa). Two-domain protein FT similar to products of two adjacent ORFs in Mycobacterium FT leprae MLCB2052.01 (644 aa), probable membrane protein and FT MLCB2052.02 (277 aa). First domain (aa 1 - 590) corresponds FT to membrane protein with similarity to P23930|LNT_ECOLI FT apolipoprotein n-acyltransferase (512 aa) while second FT domain (aa 591 - 874) is similar to Schizosaccharomyces FT pombe dolichol monophosphate mannose synthase (236 aa) and FT to Mycobacterium tuberculosis Rv0539. FASTA scores: Z FT 98604|MLCB2052_1 (644 aa) opt: 2725 E(): 0 ; 67.7% identity FT in 601 aa overlap; and Z98604|MLCB2052_2 (277 aa) opt: 1449 FT E(): 0; 78.9% identity in 275 aa overlap; and FT gp|AF0078|AF007873_1 Schizosaccharomyces pombe FT dolichocholmonophosphate mannose synthase (236 aa) opt: 456 FT E(): 7.8e-19; 34.5% identity in 223 aa overlap and FT sp|P23930|LNT_ECOLI APOLIPOPROTEIN N-ACYLTRANSFERASE (512 FT aa) opt: 330 E(): 1.9e-11; 26.9% identity in 539 aa FT overlap; and polyprenol-phosphate-mannose synthases from FT Mycobacterium smegmatis (594 aa). CAC15462.1|AJ294477 FT putative polyprenol-phosphate-mannose synthase 2 (Ppm2): FT (55% identity in 533 aa overlap)." FT /db_xref="GOA:O53493" FT /db_xref="InterPro:IPR003010" FT /db_xref="UniProtKB/TrEMBL:O53493" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17265.1" FT /translation="MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNCW FT WAAVVALALLAWVLTHRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLALATTC FT ALFPGIFGLFAVVVRLLPGWPIWFAVGWAAQEWLKSILPFGGFPWGSVAFGQAEGPLLP FT LVQLGGVALLSTGVALVGCGLTAIALEIEKWWRTGGQGDAPPAVVLPAACICLVLFAAI FT VVWPQVRHAGSGSGGEPTVTVAVVQGNVPRLGLDFNAQRRAVLDNHVEETLRLAADVHA FT GLAQQPQFVIWPENSSDIDPFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRPRENPEW FT TNTAIVWNPGTGPADRHDKAIVQPFGEYLPMPWLFRHLSGYADRAGHFVPGNGTGVVRI FT AGVPVGVATCWEVIFDRAPRKSILGGAQLLTVPSNNATFNKTMSEQQLAFAKVRAVEHD FT RYVVVAGTTGISAVIAPDGGELIRTDFFQPAYLDSQVRLKTRLTPATRWGPILQWILVG FT AAAAVVLVAMRQNGWFPRPRRSEPKGENDDSDAPPGRSEASGPPALSESDDELIQPEQG FT GRHSSGFGRHRATSRSYMTTGQPAPPAPGNRPSQRVLVIIPTFNERENLPVIHRRLTQA FT CPAVHVLVVDDSSPDGTGQLADELAQADPGRTHVMHRTAKNGLGAAYLAGFAWGLSREY FT SVLVEMDADGSHAPEQLQRLLDAVDAGADLAIGSRYVAGGTVRNWPWRRLVLSKTANTY FT SRLALGIGIHDITAGYRAYRREALEAIDLDGVDSKGYCFQIDLTWRTVSNGFVVTEVPI FT TFTERELGVSKMSGSNIREALVKVARWGIEGRLSRSDHARARPDIARPGAGGSRVSRAD FT VTE" FT CDS complement(232210..233814) FT /transl_table=11 FT /locus_tag="Rv2052c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2052c, (MTV018.39c), len: 534 aa. Conserved FT hypothetical protein, very similar to hypothetical protein FT SC6D7.15 (536 aa) from Streptomyces coelicolor A3(2). FT Smith-Waterman scores >emb|CAB61667.1| (AL133213) FT hypothetical protein SC6D7.15 [Streptomyces coelicolor FT A3(2)] Expect = e-113 Identities = 247/533 (46%)" FT /db_xref="GOA:O53494" FT /db_xref="InterPro:IPR013108" FT /db_xref="UniProtKB/TrEMBL:O53494" FT /protein_id="CAA17266.1" FT /translation="MSQIPVKLLVNGRVYSPTHPEATAMAVRGDVVAWLGSDDVGRDQF FT PDADVQDLDGRFVAPGFVDSHIHLTATGLMLSGLDLRPATSRAQCLRMVADYAADHPGQ FT PLWGHGWDESAWPENAAPSTADLDAVLGDCPAYLARIDSHSALVSSGLRRLVPELAAAT FT GYTAQRPLTGDAHHLARAAARYLLTDVQLADARAVALQAIAAAGVVAVHECAGPEIGGL FT DDWLRLRALEHGVEVIGYWGEAVATPAQARDLVTETGARGLAGDLFVDGALGSRTAWLH FT EPYADAPDCIGTCHLDVDGIEAHVRACTKAEVTAGFHVIGDAAVSAAVAAFERVVADLG FT VVAVARCGHRLEHVEMVTADQAAKLGAWGVIASVQPNFDELWGGGDGMYARRLGAQRGS FT ELNPLALLASQGVPLALGSDAPVTGFDPWASVRAAVNHRTPGSGVSARAAFAAATRGGW FT RAGGVRDGRIGTLVPGAPASYAIWDAGDFDVDAPRDAVQRWSTDPRSRVPALPRLGPTD FT ALPRCRQTVHRGAVIYG" FT CDS complement(233819..234346) FT /transl_table=11 FT /locus_tag="Rv2053c" FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv2053c, (MTV018.40c-MTCY63A.07), len: 175 aa. FT Probable transmembrane protein" FT /db_xref="GOA:O53495" FT /db_xref="InterPro:IPR007313" FT /db_xref="UniProtKB/TrEMBL:O53495" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17267.1" FT /translation="MSRLLLSYAVVELAVVFALAATIGFGWTLLVLLATFVLGFGLLAP FT LGGWQLGRRLLWLRSGLAEPRSALSDGALVTVASVLVLVPGLVTTTMGLLLLVPPIRAL FT ARPGLTAIAVRGFLRNVPLTADAAANMAGAFGESGTDPDFIDGEVIDVIDVEPLTLQPP FT RVAAEPPSPGSN" FT CDS 234422..235135 FT /transl_table=11 FT /locus_tag="Rv2054" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2054, (MTCY63A.06c), len: 237 aa. Conserved FT hypothetical protein, some similarity to various FT carboxymethylenebutenolidases e.g. sp|O67988|CLCD_RHOOP FT CARBOXYMETHYLENEBUTENOLIDASE (DIENELACTONE HYDROLASE) (DLH) FT >gi|2935034|gb|AAC38252.1| (AF003948) dienelactone FT hydrolase [Rhodococcus opacus] Smith-Waterman scores: FT Length = 252, Expect = 4e-08 Identities = 62/217 (28%). FT Also similar to Rv2765. TBparse score is 0.921" FT /db_xref="GOA:O86353" FT /db_xref="InterPro:IPR002925" FT /db_xref="UniProtKB/TrEMBL:O86353" FT /protein_id="CAA17268.1" FT /translation="MTTIEIDAPAGPIDALLGLPPGQGPWPGVVVVHDAVGYVPDNKLI FT SERIARAGYVVLTPNMYARGGRARCITRVFRELLTKRGRALDDILAARDHLLAMPECSG FT RVGIVGFCMGGQFALVLSPRGFGATAPFYGTPLPRHLSETLNGACPIVASFGTRDPLGI FT GAANRLRKVTAAKNIPADIKSYPGAGHSFANKLPGQPLVRIAGFGYNEAATEDAWRRVF FT EFFGQHLRAGSPGEP" FT CDS complement(235384..235650) FT /transl_table=11 FT /gene="rpsR2" FT /locus_tag="Rv2055c" FT /product="Probable ribosomal protein S18 RpsR2" FT /function="involved in translation, amino-acyl tRNA FT binding" FT /note="Rv2055c, (MTCY63A.05), len: 88 aa. Probable rpsR2, FT ribosomal protein S18, similar to others e.g. FT RR18_ODOSI|P49505 chloroplast 30S ribosomal protein S18 (72 FT aa), FASTA scores: opt: 209, E(): 4.7e-09, (51.6% identity FT in 64 aa overlap); etc. TBparse score is 0.907. Also FT similar to rpsR|Rv0055|MTCY21D4.18 from Mycobacterium FT tuberculosis (50.0% identity in 84 aa overlap)." FT /db_xref="GOA:P66465" FT /db_xref="InterPro:IPR018275" FT /db_xref="UniProtKB/Swiss-Prot:P66465" FT /protein_id="CAA17269.1" FT /translation="MAAKSARKGPTKAKKNLLDSLGVESVDYKDTATLRVFISDRGKIR FT SRGVTGLTVQQQRQVAQAIKNAREMALLPYPGQDRQRRAALCP" FT CDS complement(235651..235956) FT /transl_table=11 FT /gene="rpsN2" FT /locus_tag="Rv2056c" FT /product="Probable ribosomal protein S14 RpsN2" FT /function="involved in translation" FT /note="Rv2056c, (MTCY63A.04), len: 101 aa. Probable rpsN2, FT ribosomal protein S14, similar to others e.g. FT RS14_ECOLI|P02370 30S ribosomal protein S14 from FT Escherichia coli (100 aa), FASTA scores: opt: 290; E(): FT 1.7e- 13; (46.0% identity in 100 aa overlap); etc. TBparse FT score is 0.907. Also similar to rpsN|Rv0717|MTCY210.36 from FT Mycobacterium tuberculosis, (50.0% identity in 62 aa FT overlap)." FT /db_xref="GOA:P66405" FT /db_xref="InterPro:IPR018271" FT /db_xref="UniProtKB/Swiss-Prot:P66405" FT /protein_id="CAA17270.1" FT /translation="MAKKSKIVKNQRRAATVARYASRRTALKDIIRSPSSAPEQRSTAQ FT RALARQPRDASPVRLRNRDAIDGRPRGHLRKFGLSRVRVRQLAHDGHLPGVRKASW" FT CDS complement(235958..236122) FT /transl_table=11 FT /gene="rpmG1" FT /locus_tag="Rv2057c" FT /standard_name="rpmG" FT /product="Probable ribosomal protein L33" FT /function="involved in translation" FT /note="Rv2057c, (MTCY63A.03), len: 54 aa. Probable rpmG1, FT ribosomal protein L33. FASTA results: RL33_ECOLI P02436 50S FT ribosomal protein L33 (54 aa) opt: 183; E(): 1.6e-09; 51.0% FT identity in 49 aa overlap. TBparse score is 0.860. Note FT that previously known as rpmG." FT /db_xref="GOA:P0A5W0" FT /db_xref="InterPro:IPR018264" FT /db_xref="UniProtKB/Swiss-Prot:P0A5W0" FT /protein_id="CAE55449.1" FT /translation="MARTDIRPIVKLRSTAGTGYTYTTRKNRRNDPDRLILRKYDPILR FT RHVDFREER" FT CDS complement(236122..236358) FT /transl_table=11 FT /gene="rpmB2" FT /locus_tag="Rv2058c" FT /product="Probable 50S ribosomal protein L28 RpmB2" FT /function="involved in ribosome activity" FT /note="Rv2058c, (MTCY63A.02), len: 78 aa. Probable rpmB2, FT 50S ribosomal protein L28, very similar to rL28 of M. FT tuberculosis. FASTA results: RL28_MYCTU Q10879 50S FT ribosomal protein L28. mycobacter (94 aa) opt: 338; E(): FT 9.8e-19; 64.9% identity in 77 aa overlap. Also similar to FT rpmB (Rv0105c) of Mycobacterium tuberculosis. TBparse score FT is 0.929" FT /db_xref="GOA:P66148" FT /db_xref="InterPro:IPR001383" FT /db_xref="UniProtKB/Swiss-Prot:P66148" FT /protein_id="CAA17272.1" FT /translation="MSAHCQVTGRKPGFGNTVSHSHRRSRRRWSPNIQQRTYYLPSEGR FT RIRLRVSTKGIKVIDRDGIEAVVARLRRQGQRI" FT CDS 236471..238006 FT /transl_table=11 FT /locus_tag="Rv2059" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2059, (MTCY63A.01c), len: 511 aa. Conserved FT hypothetical protein. Some similarity to EWLA protein FT gp|U52850|ERU52850_1 Erysipelothrix rhusiopathiae 36 k (304 FT aa), FASTA score, opt: 287 E(): 6.9e-09; 27.2% identity in FT 228 aa overlap. There appears to be a frameshift in this FT ORF around position 3315980 that causes an overlap with FT next ORF. C-terminal end of protein may be wrong. No error FT can be found to account for this." FT /db_xref="GOA:O07257" FT /db_xref="InterPro:IPR006127" FT /db_xref="UniProtKB/TrEMBL:O07257" FT /protein_id="CAB10785.1" FT /translation="MATPVILVTGHEGTAAVTADLLGLLTDHGTATLRSVAPGSVRRAD FT PRPRCHRREQRRRHRASMKSAIHPDHHPRRLPRCPVLRRDQVVLEMIVITMVGRPSGPG FT ERKWDVWGSVARAVTGGHVPVKSILTGAHADPHSYQASPADAAAIVDAELVIYNGGGYD FT PWVDQVLAGHPGVQAVDAYSLLGAVGDDDAPNEHVFYDPNVAKAVAATIADRLADLDPS FT NSGNYRANAAEFSRGADAIAISEHAIATTYPDAAVIATEPVVHYLLAAAGLKNRTPATF FT IAANENGNDPTPADMAAVLDMIAGREVAALLVNPQTPTAATDELQVAARRAGVPITELT FT ETLPSGTDRDQFCAADRPDRRGRSLRADHADRGLSARGHRVGDLLPTALVCHRRSGGRG FT RPRRASARPGNCVRRTDGRGSRPGCPDRRGTPRDVFADHPRRGGRPGRGCPGRRDRDLG FT GLRRGFRRRRHPAVAGAWSPGVGVRGHHLVCDLPDLLVAPAAPLTSRSRFRPL" FT CDS 237576..237977 FT /transl_table=11 FT /locus_tag="Rv2060" FT /product="Possible conserved integral membrane protein" FT /function="UNKNOWN" FT /note="Rv2060, (MTV019.01), len: 133 aa. Possible conserved FT integral membrane protein smaller than but similar to FT several hypothetical bacterial proteins e.g. FT >emb|CAC29843.1| (AL583918) putative ABC-transporter FT transmembrane protein [Mycobacterium leprae] Length = 286 FT and P44691|YEBI_HAEIN (261 aa). FASTA scores: FT P44691|YEBI_HAEIN HYPOTHETICAL PROTEIN HI0407 (261 aa) opt: FT 218, E(): 4.2e-08; 31.1% identity in 122 aa overlap. Maybe FT frameshift upstream at position 3315980 but no error can be FT found to account for this. TBparse score is 0.871" FT /db_xref="GOA:O86339" FT /db_xref="InterPro:IPR001626" FT /db_xref="UniProtKB/TrEMBL:O86339" FT /protein_id="CAB10786.1" FT /translation="MLTVVCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFA FT ALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVAAIATSVVFAEVSAVGGILLS FT LAPGVPVSVFVATISFVIYLICWLLRRRR" FT CDS complement(237978..238382) FT /transl_table=11 FT /locus_tag="Rv2061c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2061c, (MTV019.02c), len: 134 aa. Conserved FT hypothetical protein. Similar to conserved hypothetical FT proteins from Mycobacterium leprae (128 aa) and FT Streptomyces coelicolor (153 aa). Smith-Waterman scores: FT >emb|CAC30396.1| (AL583922) [Mycobacterium leprae], Expect FT = 7e-47, Identities = 92/131 (70%); >emb|CAC14932.1| FT (AL449216) [Streptomyces coelicolor], Expect = 6e-19 FT Identities = 48/124 (38%). TBparse score is 0.862" FT /db_xref="GOA:O86340" FT /db_xref="InterPro:IPR019965" FT /db_xref="UniProtKB/TrEMBL:O86340" FT /protein_id="CAB10787.1" FT /translation="MTPTFSDLAEAQYLLLTTFTKDGRPKPVPIWAALDTDRGDRLLVI FT TEKKSWKVKRIRNTPRVTLATCTLRGRPTSEAVEATAAILDESQTGAVYDAIVKRYGIQ FT GKLFTFVSKLRGGMRNNIGLELKVAESETG" FT CDS complement(238466..242050) FT /transl_table=11 FT /gene="cobN" FT /locus_tag="Rv2062c" FT /product="Probable cobalamin biosynthesis protein cobN" FT /function="REQUIRED FOR COBALT INSERTION." FT /note="Rv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa. FT Probable cobN, cobalamin biosynthesis protein - very FT similar to COBN_PSEDE P29929 cobn protein. Pseudomonas FT denitrifica (1275 aa), FASTA scores, opt: 831, E(): 0, FT (37.5% identity in 983 aa overlap). Also similar to several FT Mg2+-chelatases e.g. H64479 magnesium chelatase subunit FT homolog (1226 aa )opt: 962 E(): 0; (27.3% identity in 846 FT aa overlap)" FT /db_xref="GOA:O53498" FT /db_xref="InterPro:IPR003672" FT /db_xref="UniProtKB/TrEMBL:O53498" FT /protein_id="CAA17283.1" FT /translation="MPEPTVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDLLAE FT ASIVVIRILGGYRAWQSGIDTVIAGGVPAVLVSGEQAADAELTDRSTVAAGTALQAHIY FT LAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWGVLERPDAGKTGPTIAVLYYRAQ FT HLAGNTGYVEALCRAIEDAGGRPLPLYCASLRTAEPRLLERLGGADAMVVTVLAAGGVK FT PAAASAGGDDDSWNVEHLAALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQVAVPEF FT DGRIITVPFSFKEIDDDGLISYVADPERCARVAGLAVRHARLRQVAPADKRVALVFSAY FT PTKHARIGNAVGLDTPASAVALLQAMRQRGYRVGDLPGVESNDGDALIHALIECGGHDP FT DWLTEGQLAGNPIRVSAKEYRDWFATLPAELTDVVTAYWGPPPGELFVDRSHDPDGEIV FT IAALRAGNLVLMVQPPRGFGENPVAIYHDPDLPPSHHYLAAYRWLDTGFSNGFGAHAVV FT HLGKHGNLEWLPGKTLGMSASCGPDAALGDLPLIYPFLVNDPGEGTQAKRRAHAVLVDH FT LIPPMARAETYGDIARLEQLLDEHASVAALDPGKLPAIRQQIWTLIRAAKMDHDLGLTE FT RPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQNPTGEQELDLVLAILRARQLFGGA FT HAIPGLRQALGLAEDGTDERATVDQTEAKARELVAALQATGWDPSAADRLTGNADAAAV FT LRFAATEVIPRLAGTATEIEQVLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPK FT AVPSRLAWEAGVALADSLLARYRDEHGRWPRSVGLSVWGTSAMRTAGDDIAEVLALLGV FT RPVWDDASRRVIDLAPMQPAELGRPRIDVTVRISGFFRDAFPHVVTMLDDAVRLVADLD FT EAAEDNYVRAHAQADLAHHGDQRRATTRIFGSKPGTYGAGLLQLIDSRSWRDDADLAQV FT YTAWGGFAYGRDLDGREAIDDMNRQYRRIAVAAKNTDTREHDIADSDDYFQYHGGMVAT FT VRALTGQAPAAYIGDNTRPDAIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEM FT AATVDYLFGYDATAGVMADWMYEQLTQRYVLDAQNRTFMTESNPWALHGMAERLLEAAG FT RGLWAQPAPETLDGLRQVLLETEGDLEA" FT CDS 242128..242361 FT /transl_table=11 FT /locus_tag="Rv2063" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2063, len: 77 aa. Conserved hypothetical protein, FT showing some similarity to other conserved hypothetical FT proteins e.g. AL109974_2|SCF34.02c hypothetical protein FT from Streptomyces coelicolor (133 aa), FASTA scores: opt: FT 102, E(): 1.7, (34.35% identity in 67 aa overlap); and FT AE005182_1 from Escherichia coli strain O157:H7 (77 aa), FT FASTA scores: opt: 95, E(): 3.3, (34.85% identity in 66 aa FT overlap). This ORF replaces previous Rv2063c on other FT strand." FT /db_xref="GOA:Q8VJR2" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/TrEMBL:Q8VJR2" FT /protein_id="CAE55450.1" FT /translation="MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIF FT RAEREASHAETTTQAVRDEDREWEGTVGDGLG" FT CDS 242748..243839 FT /transl_table=11 FT /gene="cobG" FT /locus_tag="Rv2064" FT /product="Possible cobalamin biosynthesis protein CobG" FT /function="REQUIRED FOR COBALAMIN BIOSYNTHESIS." FT /note="Rv2064, (MTCY49.03), len: 363 aa. Possible cobG, FT cobalamin biosynthesis protein. Some similarity to FT COBG_PSEDE P21637 cobg protein. pseudomonas (459 aa) FASTA FT scores, opt: 240, E(): 1.3e-08, (27.5% identity in 407 aa FT overlap); contains PS01156 TonB-dependent receptor proteins FT signature 2" FT /db_xref="GOA:Q10675" FT /db_xref="InterPro:IPR012798" FT /db_xref="UniProtKB/TrEMBL:Q10675" FT /protein_id="CAA98212.1" FT /translation="MAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLASV FT ASDFGSATLELTARGNVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLSGRAG FT GLADVRAWVGELDAAIRAEPRLAELGGRFWFGLDDGRADVSGLGADVGVQVFPDGPRLL FT LTGRDTGVRVADVAETLIEVALRFVKIRETAWRVTELADIGELQSGVELGPSVRPVTKT FT PVGWIPQDDSRVTLGAAVPLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDATADAA FT LRVLAPLGLVFDENSPWLNISACTGSPGCAHSAADVRADAARSLNVESAGHRHFVGCER FT ACGSPPAGEVLVATGGGYRRLRP" FT misc_feature 243099..243152 FT /note="PS01156 TonB-dependent receptor proteins signature FT 2" FT CDS 243849..244475 FT /transl_table=11 FT /gene="cobH" FT /locus_tag="Rv2065" FT /product="Probable precorrin-8X methylmutase CobH (aka FT precorrin isomerase)" FT /function="REQUIRED FOR COBALAMIN BIOSYNTHESIS." FT /EC_number="5.4.1.2" FT /note="Rv2065, (MTCY49.04), len: 208 aa. Probable cobH, FT precorrin-8X methylmutase (aka precorrin isomerase) (EC FT 5.4.1.2), similar to COBH_PSEDE P21638 precorrin isomerase FT (210 aa), FASTA scores: opt: 750, E(): 0, (55.4% identity FT in 202 aa overlap)." FT /db_xref="GOA:P63839" FT /db_xref="HSSP:1F2V" FT /db_xref="InterPro:IPR003722" FT /db_xref="UniProtKB/Swiss-Prot:P63839" FT /protein_id="CAA98213.1" FT /translation="MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQ FT VDVAEHVAYTDDVVARAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVADPRAT FT ELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGGPVG FT FVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE" FT CDS 244472..245998 FT /transl_table=11 FT /gene="cobI" FT /locus_tag="Rv2066" FT /product="Probable bifunctional protein, CobI-CobJ fusion FT protein: S-adenosyl-L-methionine-precorrin-2 methyl FT transferase + precorrin-3 methylase" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS." FT /EC_number="2.1.1.-" FT /note="Rv2066, (MTCY49.05), len: 508 aa. Probable CobI-CobJ FT fusion protein, S-adenosyl-L-methionine-precorrin-2 methyl FT transferase and precorrin-3 methylase (EC 2.1.1.-). Similar FT in N-terminal half (aa 1-240) to COBI_PSEDE|P21639, FT S-adenosyl-L-methionine-precorrin-2 methyl transferase (244 FT aa), FASTA scores: opt: 759, E(): 4.4e-34, (49.2% identity FT in 238 aa overlap); and in C-terminal half (aa 240-508) to FT P21640|COBJ_PSEDE PRECORRIN-3 METHYLASE (EC 2.1.1.-) (254 FT aa), FASTA scores: opt: 695, E(): 0, (45.3% identity in 258 FT aa overlap)." FT /db_xref="GOA:P66877" FT /db_xref="InterPro:IPR003043" FT /db_xref="UniProtKB/Swiss-Prot:P66877" FT /protein_id="CAA98214.1" FT /translation="MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSI FT ARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVA FT LLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGT FT LPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAAD FT VDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRG FT YLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEA FT EQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADL FT VLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLN FT PAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD" FT CDS complement(245944..247167) FT /transl_table=11 FT /locus_tag="Rv2067c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv2067c, (MTCY49.06c), len: 407 aa. Conserved FT hypothetical protein, some similarity to YAT1_SYNP6 P08442 FT atp synthase subunits region ORF 1. (417 aa), FASTA scores, FT opt: 373, E(): 4.9e-18, (27.7% identity in 358 aa overlap)" FT /db_xref="InterPro:IPR013217" FT /db_xref="UniProtKB/Swiss-Prot:P0A5G1" FT /protein_id="CAA98215.1" FT /translation="MTDDHPRADIVSRQYHRWLYPHPIADLEAWTTANWEWFDPVHSHR FT ILWPDREYRPDLDILIAGCGTNQAAIFAFTNRAAKVVAIDISRPALDHQQYLKDKHGLA FT NLELHLLPIEELATLGRDFDLVVSTGVLHHLADPRAGMKELAHCLRRDGVVAAMLYGKY FT GRIGVELLGSVFRDLGLGQDDASIKLAKEAISLLPTYHPLRNYLTKARDLLSDSALVDT FT FLHGRQRSYTVEECVDLVTSAGLVFQGWFHKAPYYPHDFFVPNSEFYAAVNTLPEVKAW FT SVMERLETLNATHLFMACRRDRPKEQYTIDFSTVAALDYVPLMRTRCGVSGTDMFWPGW FT RMAPSPAQLAFLQQVDGRRTIREIAGCVARTGEPSGGSLADLEEFGRKLFQSLWRLDFV FT AVALPASG" FT CDS complement(247183..248106) FT /transl_table=11 FT /gene="blaC" FT /locus_tag="Rv2068c" FT /product="CLASS A BETA-LACTAMASE BLAC" FT /function="hydrolyses beta-lactams to generate FT corresponding beta-amino acid [CATALYTIC ACTIVITY: A FT BETA-LACTAM + H(2)O = A SUBSTITUTED BETA-AMINO ACID]." FT /EC_number="3.5.2.6" FT /note="Rv2068c, (MTCY49.07c), len: 307 aa. blaC, class A FT beta-lactamase (EC 3.5.2.6) (see citation below), similar FT to e.g. BLAC_NOCLA Q06316 beta-lactamase precursor (302 FT aa), FASTA scores, opt: 860, E(): 0, (50.2% identity in 283 FT aa overlap); eyc. Contains PS00013 Prokaryotic lipid FT attachment site near N-terminus, and PS00146 Beta-lactamase FT class-A active site. BELONGS TO THE CLASS-C BETA-LACTAMASE FT FAMILY." FT /db_xref="GOA:P0C5C1" FT /db_xref="InterPro:IPR000871" FT /db_xref="PDB:2GDN" FT /db_xref="UniProtKB/Swiss-Prot:P0C5C1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98216.1" FT /translation="MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLA FT DRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLD FT KLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAA FT FTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRAL FT LTDWMARNTTGAKRIRAGFPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDR FT AGGGYDAEPREALLAEAATCVAGVLA" FT misc_feature complement(247822..247869) FT /note="PS00146 Beta-lactamase class-A active site" FT CDS 248241..248798 FT /transl_table=11 FT /gene="sigC" FT /locus_tag="Rv2069" FT /product="PROBABLE RNA POLYMERASE SIGMA FACTOR, ECF FT SUBFAMILY, SIGC" FT /function="INVOLVED IN PROMOTER RECOGNITION, TRANSCRIPTION FT INITIATION." FT /note="Rv2069, (MTCY49.08), len: 185 aa. Probable sigC, RNA FT polymerase sigma factor, ECF subfamily (see Gomez et al., FT 1997; Chen et al., 2000), with similarity to FT SIGX_BACSU|P35165 probable RNA polymerase sigma factor from FT Bacillus subtilis (194 aa), FASTA scores: opt: 218, E(): FT 4.1e-07, (32.6% identity in 129 aa overlap). Belongs to ECF FT subfamily." FT /db_xref="GOA:P66809" FT /db_xref="InterPro:IPR013249" FT /db_xref="PDB:2O7G" FT /db_xref="UniProtKB/Swiss-Prot:P66809" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98224.1" FT /translation="MTATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLS FT DVGSADDLTQETFLRAIGAIPRFSARSSARTWLLAIARHVVADHIRHVRSRPRTTRGAR FT PEHLIDGDRHARGFEDLVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPVGTI FT RSRVARARDALLADAEPDDLTG" FT CDS complement(248788..249522) FT /transl_table=11 FT /gene="cobK" FT /locus_tag="Rv2070c" FT /product="Probable precorrin-6X reductase CobK" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS." FT /EC_number="1.3.1.54" FT /note="Rv2070c, (MTCY49.09c), len: 244 aa. Probable cobK, FT precorrin-6x reductase (EC 1.3.1.54), similar to e.g. FT L21196|g347169|RERCOBLMK3 RERCOBLMKN from Rhodococcus sp. FT NI86/21 (248 aa), FASTA scores: opt: 792, E(): 0, (53.6% FT identity in 250 aa overlap). Also similarity to FT CBIJ_SALTY|Q05591 cbij protein from Salmonella typhimurium FT (263 aa), FASTA scores: opt: 166, E(): 9e-0 5, (26.7% FT identity in 258 aa overlap)." FT /db_xref="GOA:Q10680" FT /db_xref="InterPro:IPR003723" FT /db_xref="UniProtKB/Swiss-Prot:Q10680" FT /protein_id="CAA98217.1" FT /translation="MTRVLLLGGTAEGRALAKELHPHVEIVSSLAGRVPNPALPIGPVR FT IGGFGGVEGLRGWLREERIDAVVDATHPFAVTITAHAAQVCGELGLPYLVLARPPWDPG FT TAIIAVSDIEAADVVAEQGYSRVFLTTGRSGIAAFANSDAWFLIRVVTAPDGTALPRRH FT KLVLSRGPYGYHDEFALLREQRIDALVTKNSGGKMTRAKLDAAAALGISVVMIARPLLP FT AGVAAVDSVHRAAMWVAGLPSR" FT CDS complement(249519..250274) FT /transl_table=11 FT /gene="cobM" FT /locus_tag="Rv2071c" FT /product="Probable precorrin-4 C11-methyltransferase CobM" FT /function="INVOLVED IN COBALAMIN BIOSYNTHESIS." FT /EC_number=" |