EBI Dbfetch

ID   BX842577; SV 1; linear; genomic DNA; STD; PRO; 347496 BP.
XX
AC   BX842577; AL022000-AL022003; AL022021; Z74020; Z78020; Z81360; Z85982;
AC   Z95554; Z95586; Z95617; Z95890; Z96073; Z97345; Z98268; Z98943;
XX
DT   21-NOV-2003 (Rel. 77, Created)
DT   23-OCT-2008 (Rel. 97, Last updated, Version 6)
XX
DE   Mycobacterium tuberculosis H37Rv complete genome; segment 6/13
XX
KW   complete genome.
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
XX
RN   [1]
RX   DOI; 10.1038/31159
RX   PUBMED; 9634230.
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence";
RL   Nature 393(6685):537-544(1998).
XX
RN   [2]
RX   PUBMED; 12368430.
RA   Camus J.C., Pryor M.J., Medigue C., Cole S.T.;
RT   "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv";
RL   Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002).
XX
RN   [3]
RP   1-347496
RA   Parkhill J.;
RT   ;
RL   Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases.
RL   Submitted on behalf of the Mycobacterium tuberculosis sequencing and
RL   mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton,
RL   Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut
RL   Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
RL   parkhill@sanger.ac.uk
XX
DR   EMBL-CON; AL123456.
DR   RFAM; RF00504; Glycine.
XX
CC   Notes:
CC   Details of M. tuberculosis sequencing at the Sanger Centre
CC   are available on the World Wide Web.
CC   (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/)
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..347496
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:83332"
FT   CDS             116..1219
FT                   /transl_table=11
FT                   /gene="adh"
FT                   /locus_tag="Rv1530"
FT                   /product="Probable alcohol dehydrogenase adh"
FT                   /function="Catalyzes the reversible oxidation of ethanol to
FT                   acetaldehyde with the concomitant reduction of NAD"
FT                   /EC_number="1.1.1.1"
FT                   /note="Rv1530, (MTV045.04), len: 367 aa. Probable adh,
FT                   alcohol dehydrogenase (EC 1.1.1.1), zinc-dependent, similar
FT                   to many e.g. AE0009|AE000958_23 Archaeoglobus fulgidus
FT                   section 1 (402 aa), FASTA scores: opt: 423, E(): 1.8e-19,
FT                   (31.7% identity in 341 aa overlap). Contains PS00059
FT                   Zinc-containing alcohol dehydrogenases signature. TBparse
FT                   score is 0.919."
FT                   /db_xref="GOA:O53904"
FT                   /db_xref="InterPro:IPR013154"
FT                   /db_xref="UniProtKB/TrEMBL:O53904"
FT                   /protein_id="CAA17590.1"
FT                   /translation="MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGT
FT                   DHEQYTGELAGGFAFVPGHETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCRQCANCR
FT                   GGEYRRCVRHGLADMYGFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFN
FT                   PLGAGIRWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLA
FT                   LAAQFGADLAVDVAIDDPVAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVV
FT                   AGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAALDLLVSGRYPFASLPRRCVR
FT                   LEGAEDLLATMAGERDGVPPIHGVLTP"
FT   misc_feature    302..346
FT                   /note="PS00059 Zinc-containing alcohol dehydrogenases
FT                   signature"
FT   CDS             1216..1782
FT                   /transl_table=11
FT                   /locus_tag="Rv1531"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1531, (MTV045.05), len: 188 aa. Conserved
FT                   hypothetical protein, similar to Rv0464c|MTV038.08c (190
FT                   aa), FASTA scores: E(): 4.8e-10, (30.9% identity in 175 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR003779"
FT                   /db_xref="UniProtKB/TrEMBL:O53905"
FT                   /protein_id="CAA17591.1"
FT                   /translation="MTTSRVPLLPVDEAKAAADEAGVPDYMAELSIFQVLLNHPRLART
FT                   FNDLLATMLWHGTLDSRLRELVIMRIGWLTDCDYEWTQHWRVASGLGVSADDLLGVRDW
FT                   QGYNGFGPAEQAVLAATDDVVREGAVSAQSWSACERELHCDKVVLIELVTVISAWRMVA
FT                   SILHSLEVPLEDGVSSWPPDGLSPR"
FT   CDS             complement(1859..2293)
FT                   /transl_table=11
FT                   /locus_tag="Rv1532c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1532c, (MTCY07A7A.01c), len: 144 aa. Conserved
FT                   hypothetical protein, similar to P20378|YPHR_HALHA
FT                   Hypothetical 15.6 kDa protein from Halobacterium halobium
FT                   (151 aa), FASTA scores: opt: 152, E():4.5e-05, (30.1%
FT                   identity in 103 aa overlap)."
FT                   /db_xref="InterPro:IPR006683"
FT                   /db_xref="UniProtKB/TrEMBL:O06178"
FT                   /protein_id="CAB11594.1"
FT                   /translation="MSDPLTAQEQHKRRQAVRELMPRTPFIGGLGIVFERYEPDDVVIR
FT                   LPFRTDLTNDGTYFHGGVIASVMDTAGAAAAWSNHDFDRGTRAATVAMSIQYTGAAKRC
FT                   DLLCHARTARRRKELTFTEITATDPDGNIVAHAVQTYRIV"
FT   CDS             2353..3480
FT                   /transl_table=11
FT                   /locus_tag="Rv1533"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1533, (MTCY07A7A.02), len: 375 aa. Conserved
FT                   hypothetical protein. Similar to 2NPD_NEUCR|Q01284
FT                   2-nitropropane dioxygenase precursor (378 aa), fasta
FT                   scores: opt: 279, E(): 9.1e-11, (31.3% identity in 256 aa
FT                   overlap). Also similar to Mycobacterium tuberculosis
FT                   hypothetical proteins Rv1894c, Rv0021c, Rv3553, Rv2781c."
FT                   /db_xref="GOA:O06179"
FT                   /db_xref="InterPro:IPR013785"
FT                   /db_xref="UniProtKB/TrEMBL:O06179"
FT                   /protein_id="CAB11595.1"
FT                   /translation="MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPK
FT                   RLESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQARELIPEGHRTFVDDLLVR
FT                   YGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHDIRLIASALGPPPPDLVERAHNHD
FT                   VLVAALAGTAQHARRHAAAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAVSPTPVLAA
FT                   GGIARGRQIAAALALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGK
FT                   PARMLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQ
FT                   VVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR"
FT   CDS             3477..4154
FT                   /transl_table=11
FT                   /locus_tag="Rv1534"
FT                   /product="Probable transcriptional regulator"
FT                   /function="Possibly involved in a transcriptional
FT                   mechanism"
FT                   /note="Rv1534, (MTCY07A7A.03), len: 225 aa. Probable
FT                   transcriptional regulator, similar to YCDC_ECOLI|P75899
FT                   hypothetical transcriptional regulator from Escherichia
FT                   coli (212 aa), FASTA scores: opt: 166, E(): 9.8e-05, (24.2%
FT                   identity in 219 aa overlap). Contains PS01081 Bacterial
FT                   regulatory proteins, tetR family signature and helix turn
FT                   helix motif (aa 41-62)."
FT                   /db_xref="GOA:O08377"
FT                   /db_xref="InterPro:IPR012287"
FT                   /db_xref="UniProtKB/TrEMBL:O08377"
FT                   /protein_id="CAB11596.1"
FT                   /translation="MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVADI
FT                   AKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRALLQAA
FT                   VQATFEFFETDKATVKLLFRDAYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVE
FT                   APSRMAAYTLAALVGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRA
FT                   ART"
FT   misc_feature    3582..3674
FT                   /note="PS01081 Bacterial regulatory proteins, tetR family
FT                   signature"
FT   CDS             4719..4955
FT                   /transl_table=11
FT                   /locus_tag="Rv1535"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1535, (MTCY07A7A.04), len: 78 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O06180"
FT                   /protein_id="CAB11597.1"
FT                   /translation="MTAALHNDVVTVASAPKLRVVRDVPPAPASKKVARRLDAQPFGTG
FT                   GDPLVDGAARLLSIPLRHLYAALWRVGLLEVQA"
FT   CDS             5262..8387
FT                   /transl_table=11
FT                   /gene="ileS"
FT                   /locus_tag="Rv1536"
FT                   /product="isoleucyl-tRNA synthetase ileS"
FT                   /function="charging ile tRNA [CATALYTIC ACTIVITY : ATP +
FT                   L-ISOLEUCINE + TRNA(ILE) = AMP + DIPHOSPHATE +
FT                   L-ISOLEUCYL-TRNA(ILE)]."
FT                   /EC_number="6.1.1.5"
FT                   /note="Rv1536, (MTCY48.29c-MTCCY07A7A.05), len: 1041 aa.
FT                   ileS, Isoleucyl-tRNA synthetase (EC 6.1.1.5) , similar to
FT                   several e.g. SYIC_YEAST P09436 isoleucyl-tRNA synthetase
FT                   (1072 aa), FASTA scores: opt: 1447, E(): 0, (37.8% identity
FT                   in 1072 aa overlap); contains PS00178 Aminoacyl-transfer
FT                   RNA synthetases class-I signature. BELONGS TO CLASS-I
FT                   AMINOACYL-TRNA SYNTHETASE FAMILY."
FT                   /db_xref="GOA:Q10765"
FT                   /db_xref="HSSP:1ILE"
FT                   /db_xref="InterPro:IPR013155"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10765"
FT                   /protein_id="CAA98326.1"
FT                   /translation="MTDNAYPKLAGGAPDLPALELEVLDYWSRDDTFRASIARRDGAPE
FT                   YVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQ
FT                   LGITDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMES
FT                   VIWAFKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTVGFKVVG
FT                   GQPDNGLDGAYLLVWTTTPWTLPSNLAVAVSPDITYVQVQAGDRRFVLAEARLAAYARE
FT                   LGEEPVVLGTYRGAELLGTRYLPPFAYFMDWPNAFQVLAGDFVTTDDGTGIVHMAPAYG
FT                   EDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSGPAAVNGP
FT                   VLIRHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHVKDGQ
FT                   FGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDELERDFGVRPANLHRP
FT                   YIDELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMPYAQVHYPFENLDWFQGHYPGDFI
FT                   VEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFD
FT                   RDGSDAMRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPLWNTYSFLALYAPKVGTWRV
FT                   DSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALTNWYVRRSRSRFWAE
FT                   DADAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTRERSVHLTDWPAPDLLPSDADLVA
FT                   AMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAVENPQLLRPFVDLIGDELNVKQVELT
FT                   DAIDTYGRFELTVNARVAGPRLGKDVQAAIKAVKAGDGVINPDGTLLAGPAVLTPDEYN
FT                   SRLVAADPESTAALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLDVSDRI
FT                   RVVMSVPAEREDWARTHRDLIAGEILATDFEFADLADGVAIGDGVRVSIEKT"
FT   misc_feature    5418..5453
FT                   /note="PS00178 Aminoacyl-transfer RNA synthetases class-I
FT                   signature"
FT   CDS             8599..9990
FT                   /transl_table=11
FT                   /gene="dinX"
FT                   /locus_tag="Rv1537"
FT                   /standard_name="dinB1"
FT                   /product="PROBABLE DNA POLYMERASE IV DINX (POL IV 1) (DNA
FT                   NUCLEOTIDYLTRANSFERASE (DNA-DIRECTED))"
FT                   /function="INVOLVED IN DNA METABOLISM [CATALYTIC ACTIVITY:
FT                   N DEOXYNUCLEOSIDE TRIPHOSPHATE = N DIPHOSPHATE + {DNA}N]."
FT                   /EC_number="2.7.7.7"
FT                   /note="Rv1537, (MTCY48.28c, MT1589), len: 463 aa. Probable
FT                   dinX (alternate gene name: dinB1), DNA polymerase IV (EC
FT                   2.7.7.7). Similar to umuC, mucB, samb, and impb (UV
FT                   protection and mutation) e.g. IMPB_SALTY|P18642 impb
FT                   protein from Salmonella typhimurium (424 aa), FASTA scores:
FT                   opt: 386, E(): 1.7e-17, (27.5% identity in 415 aa overlap);
FT                   etc. Also similar to Mycobacterium tuberculosis
FT                   Rv3056|dinP. BELONGS TO THE DNA POLYMERASE TYPE-Y FAMILY."
FT                   /db_xref="GOA:P63985"
FT                   /db_xref="HSSP:1JX4"
FT                   /db_xref="InterPro:IPR017963"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63985"
FT                   /protein_id="CAA98325.1"
FT                   /translation="MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEAR
FT                   AYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFA
FT                   EPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVR
FT                   HAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALH
FT                   RLARGIDDRPVVERAEAKQISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGAR
FT                   TITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSD
FT                   IRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGH
FT                   GVVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVD
FT                   DVGDR"
FT   CDS             complement(9955..10935)
FT                   /transl_table=11
FT                   /gene="ansA"
FT                   /locus_tag="Rv1538c"
FT                   /product="Probable L-aparaginase ansA"
FT                   /function="conversion of asparagine to aspartate [CATALYTIC
FT                   ACTIVITY : L-ASPARAGINE + H(2)O = L-ASPARTATE + NH(3).]"
FT                   /EC_number="3.5.1.1"
FT                   /note="Rv1538c, (MTCY48.27), len: 326 aa. Probable ansA,
FT                   L-aparaginase, most similar to ASPG_BACLI|P30363
FT                   L-asparaginase (322 aa), FASTA scores: opt: 417, E():
FT                   8.8e-19, (30.9% identity in 314 aa overlap). Contains
FT                   PS00917 Asparaginase / glutaminase active site signature
FT                   2."
FT                   /db_xref="GOA:P63627"
FT                   /db_xref="HSSP:3PGA"
FT                   /db_xref="InterPro:IPR006034"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63627"
FT                   /protein_id="CAA98324.1"
FT                   /translation="MGANHVRNDPIMARLTVITTGGTISTTAGPDGVLRPTHCGATLIA
FT                   GLDMDSDIEVVDLMALDSSKLTPADWDRIGAAVQEAFRGGADGVVITHGTDTLEETALW
FT                   LDLTYAGSRPVVLTGAMLSADAPGADGPANLRDALAVAADPAARDLGVLVSFGGRVLQP
FT                   LGLHKVANPDLCGFAGESLGFTSGGVRLTRTKTRPYLGDLGAAVAPRVDIVAVYPGSDA
FT                   VAMDACVAAGARAVVLEALGSGNAGAAVIEGVRRHCRDGSDPVVIAVSTRVAGARVGAG
FT                   YGPGHDLVEAGAVMVPRLPPSQARVLLMAALAANSPVADVIDRWG"
FT   misc_feature    complement(10642..10674)
FT                   /note="PS00917 Asparaginase / glutaminase active site
FT                   signature 2"
FT   CDS             10987..11595
FT                   /transl_table=11
FT                   /gene="lspA"
FT                   /locus_tag="Rv1539"
FT                   /product="PROBABLE LIPOPROTEIN SIGNAL PEPTIDASE LSPA"
FT                   /function="THIS PROTEIN SPECIFICALLY CATALYZES THE REMOVAL
FT                   OF SIGNAL PEPTIDES FROM PROLIPOPROTEINS [CATALYTIC ACTIVITY
FT                   : CLEAVAGE OF N-TERMINAL LEADER SEQUENCES FROM MEMBRANE
FT                   PROLIPOPROTEINS. HYDROLYSES XAA-XBB-XBB-|-CYS, IN WHICH XAA
FT                   IS HYDROPHOBIC (PREFERABLY LEU), XBB IS OFTEN SER OR ALA,
FT                   XCC IS OFTEN GLY OR ALA, AND THE CYS IS ALKYLATED ON SULFUR
FT                   WITH A DIACYLGLYCERYL GROUP]."
FT                   /EC_number="3.4.23.36"
FT                   /note="Rv1539, (MTCY48.26c), len: 202 aa. Probable lspA,
FT                   lipoprotein signal peptidase (EC 3.4.23.36) (see citation
FT                   below), similar to several e.g. LSPA_PSEFL|P17942 (170 aa),
FT                   FASTA scores: opt: 299, E(): 2.6e-12, (38.3% identity in
FT                   167 aa overlap)."
FT                   /db_xref="GOA:P65262"
FT                   /db_xref="InterPro:IPR001872"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65262"
FT                   /protein_id="CAA98323.1"
FT                   /translation="MPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLT
FT                   LDIVTKVVAVQLLPPGQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVVGI
FT                   FWMGRRLVSPWWALGLGMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNVADP
FT                   SVVGGAILLVILSIFGFDFDTVGRRHADGDTVGRRKADG"
FT   CDS             11588..12514
FT                   /transl_table=11
FT                   /locus_tag="Rv1540"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN MEMBER OF
FT                   yabO/yceC/yfiI FAMILY"
FT                   /function="UNKNOWN"
FT                   /note="Rv1540, (MTCY48.25c), len: 308 aa. Member of the
FT                   yabO/yceC/yfiI family of hypothetical proteins, similar to
FT                   P44445|YFII_HAEIN hypothetical protein HI0176 from
FT                   Haemophilus influenzae (324 aa), FASTA scores: opt: 437,
FT                   E(): 1.2e-22, (33.2% identity in 322 aa overlap).
FT                   Equivalent to AL049478|MLCL458_13 hypothetical protein from
FT                   Mycobacterium leprae (308 aa), (89.3% identity in 307 aa
FT                   overlap). Contains PS01129 hypothetical yabO/yceC/yfiI
FT                   family signature."
FT                   /db_xref="GOA:P0A5T2"
FT                   /db_xref="InterPro:IPR002942"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5T2"
FT                   /protein_id="CAA98322.1"
FT                   /translation="MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELNG
FT                   VPAGKSDRLVSGALLQVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAVAAHAS
FT                   VGWTGPTVLGGLAAAGYRITTSGVHERQGIVHRLDVGTSGVMVVAISERAYTVLKRAFK
FT                   YRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEWKFAITKNGRHSLTHYDTLEAFVAA
FT                   SLLDVHLETGRTHQIRVHFAALHHPCCGDLVYGADPKLAKRLGLDRQWLHARSLAFAHP
FT                   ADGRRVEIVSPYPADLQHALKILRGEG"
FT   misc_feature    11993..12034
FT                   /note="PS01129 Hypothetical yabO/yceC/yfiI family
FT                   signature"
FT   CDS             complement(12521..13114)
FT                   /transl_table=11
FT                   /gene="lprI"
FT                   /locus_tag="Rv1541c"
FT                   /product="Possible lipoprotein lprI"
FT                   /function="UNKNOWN"
FT                   /note="Rv1541c, (MTCY48.24), len: 197 aa. Possible
FT                   lipoprotein lprI, contains appropriately positioned
FT                   prokaryotic membrane lipoprotein lipid attachment site
FT                   (PS0013)."
FT                   /db_xref="GOA:P65318"
FT                   /db_xref="InterPro:IPR018660"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65318"
FT                   /protein_id="CAA98321.1"
FT                   /translation="MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQL
FT                   VCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQ
FT                   TRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELS
FT                   GSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS"
FT   CDS             complement(13169..13579)
FT                   /transl_table=11
FT                   /gene="glbN"
FT                   /locus_tag="Rv1542c"
FT                   /product="Probable hemoglobin glbN"
FT                   /function="oxygen transport"
FT                   /note="Rv1542c, (MTCY48.23), len: 136 aa. Probable glbN,
FT                   hemoglobin. Belongs to the protozoan/cyanobacterial globin
FT                   family. Similar to myoglobins e.g. GLB_PARCA|P15160
FT                   myoglobin (hemoglobin) paramecium (116 aa), FASTA scores,
FT                   opt: 284, E(): 2.1e -13, (35.7% identity in 115 aa
FT                   overlap). Similar to Mycobacterium tuberculosis
FT                   hypothetical globin, Rv2470."
FT                   /db_xref="GOA:P0A592"
FT                   /db_xref="InterPro:IPR016339"
FT                   /db_xref="PDB:1IDR"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A592"
FT                   /protein_id="CAA98320.1"
FT                   /translation="MGLLSRLRKREPISIYDKIGGHEAIEVVVEDFYVRVLADDQLSAF
FT                   FSGTNMSRLKGKQVEFFAAALGGPEPYTGAPMKQVHQGRGITMHHFSLVAGHLADALTA
FT                   AGVPSETITEILGVIAPLAVDVTSGESTTAPV"
FT   CDS             13807..14832
FT                   /transl_table=11
FT                   /locus_tag="Rv1543"
FT                   /product="POSSIBLE FATTY ACYL-CoA REDUCTASE"
FT                   /function="Thought to reduce acyl-CoA esters of fatty acids
FT                   to fatty aldehydes."
FT                   /EC_number="1.2.1.-"
FT                   /note="Rv1543, (MTCY48.22c), len: 341 aa. Possible
FT                   fatty-acyl CoA reductase (EC 1.2.1.-), highly similar to
FT                   P94129|U77680 FATTY ACYL-CoA REDUCTASE ACR1 from
FT                   Acinetobacter calcoaceticus (295 aa), FASTA scores: opt:
FT                   899, E(): 0, (48.5% identity in 293 aa overlap). Also
FT                   highly similar to
FT                   acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty acyl-CoA
FT                   reductase from Mycobacterium tuberculosis (650 aa). Also
FT                   highly similar to many oxidoreductases short-chain family."
FT                   /db_xref="GOA:P66779"
FT                   /db_xref="HSSP:1FDW"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66779"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA98319.1"
FT                   /translation="MNLGDLTNFVEKPLAAVSNIVNTPNSAGRYRPFYLRNLLDAVQGR
FT                   NLNDAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVARTLENLENVANDIRAIRGNG
FT                   GTAHVYPCDLSDMDAIAVMADQVLGDLGGVDILINNAGRSIRRSLELSYDRIHDYQRTM
FT                   QLNYLGAVQLILKFIPGMRERHFGHIVNVSSVGVQTRAPRFGAYIASKAALDSLCDALQ
FT                   AETVHDNVRFTTVHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPF
FT                   GQFAAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSETFVRATRGIH
FT                   W"
FT   CDS             14837..15640
FT                   /transl_table=11
FT                   /locus_tag="Rv1544"
FT                   /product="Possible ketoacyl reductase"
FT                   /function="UNKNOWN, BUT POSSIBLY INVOLVEMENT IN LIPID
FT                   METABOLISM."
FT                   /EC_number="1.3.1.-"
FT                   /note="Rv1544, (MTCY48.21), len: 267 aa. Possible ketoacyl
FT                   reductase (EC 1.3.1.-), highly similar to Z97179|MLCL383_26
FT                   putative oxidoreductase from Mycobacterium leprae (268 aa),
FT                   FASTA score: (43.0% identity in 270 aa overlap). Also
FT                   highly similar to others e.g. T29125 ketoacyl reductase
FT                   homolog from Streptomyces coelicolor (276 aa);
FT                   NP_470957.1|NC_003212 protein similar to ketoacyl
FT                   reductases from Listeria innocua (253 aa);
FT                   HETN_ANASP|P37694 ketoacyl reductase from Anabaena sp.
FT                   strain PCC 7120 (287 aa), FASTA scores: opt: 379, E():
FT                   7.5e-18, (31.6% identity in 250 aa overlap); etc. And
FT                   highly similar to many oxidoreductases short-chain family.
FT                   Also highly similar to Rv2509 from Mycobacterium
FT                   tuberculosis (268 aa). Contains PS00061 Short-chain alcohol
FT                   dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN
FT                   DEHYDROGENASES/REDUCTASES (SDR) FAMILY."
FT                   /db_xref="GOA:Q10782"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q10782"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA98318.1"
FT                   /translation="MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRER
FT                   LDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGLCNSAGFGTSGRFWEL
FT                   PFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAGFQPIPYMAVYSATKAF
FT                   VLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIASAERFSIPLAQVSPHDVAEAAIAG
FT                   MLSGKRTVVPGIVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR"
FT   misc_feature    15266..15352
FT                   /note="PS00061 Short-chain alcohol dehydrogenase family
FT                   signature"
FT   CDS             15662..15889
FT                   /transl_table=11
FT                   /locus_tag="Rv1545"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1545, (MTCY48.20), len: 75 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/Swiss-Prot:P64871"
FT                   /protein_id="CAA98317.1"
FT                   /translation="MPNGVLGLGNPSRLAALYGLQLAHESQCCQMHNLPSAARQVTVAC
FT                   REEVGITTILAGRDECGVCDKTAGLDGAAP"
FT   CDS             15938..16369
FT                   /transl_table=11
FT                   /locus_tag="Rv1546"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1546, (MTCY48.19c), len: 143 aa. Conserved
FT                   hypothetical protein, similar to O05902|Rv0910|MTCY21C12.04
FT                   Hypothetical protein from Mycobacterium tuberculosis (144
FT                   aa), FASTA scores: E(): 5e-30, (37.3% identity in 142 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR019587"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64873"
FT                   /protein_id="CAA98316.1"
FT                   /translation="MASVELSADVPISPQDTWDHVSELSELGEWLVIHEGWRSELPDQL
FT                   GEGVQIVGVARAMGMRNRVTWRVTKWDPPHEVAMTGSGKGGTKYGVTLTVRPTKGGSAL
FT                   GLRLELGGRALFGPLGSAAARAVKGDVEKSLKQFAELYG"
FT   CDS             16437..19991
FT                   /transl_table=11
FT                   /gene="dnaE1"
FT                   /locus_tag="Rv1547"
FT                   /product="PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1
FT                   (DNA NUCLEOTIDYLTRANSFERASE)"
FT                   /function="DNA POLYMERASE III IS A COMPLEX, MULTICHAIN
FT                   ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN
FT                   BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5'
FT                   EXONUCLEASE ACTIVITY. THE ALPHA CHAIN IS THE DNA POLYMERASE
FT                   [CATALYTIC ACTIVITY : N DEOXYNUCLEOSIDE TRIPHOSPHATE = N
FT                   DIPHOSPHATE + {DNA}(N)]."
FT                   /EC_number="2.7.7.7"
FT                   /note="Rv1547, (MTCY48.18c), len: 1184 aa. Probable dnaE1,
FT                   DNA polymerase III, alpha chain (EC 2.7.7.7) (see citation
FT                   below), similar to many e.g. DP3A_ECOLI|P10443 dna
FT                   polymerase III, alpha chain (1160 aa), FASTA scores: opt:
FT                   1789, E(): 0, (36.5% identity in 1193 aa overlap). Also
FT                   similar to M. tuberculosis, DnaE2|Rv3370c. BELONGS TO DNA
FT                   POLYMERASE TYPE-C FAMILY, DNAE SUBFAMILY."
FT                   /db_xref="GOA:P63977"
FT                   /db_xref="InterPro:IPR004805"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63977"
FT                   /protein_id="CAA98315.1"
FT                   /translation="MSGSSAGSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGM
FT                   TDHGNMFGASEFYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQKADDVSGSGS
FT                   YTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELIAEHAEGIIITTGCPSGEV
FT                   QTRLRLGQDREALEAAAKWREIVGPDNYFLELMDHGLTIERRVRDGLLEIGRALNIPPL
FT                   ATNDCHYVTRDAAHNHEALLCVQTGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVPG
FT                   ACDSTLLIAERVQSYADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGLRRRFPAGPPDG
FT                   YRERAAYEIDVICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLVAYALGITDI
FT                   DPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKT
FT                   KAALKDSARIHYGQPGFAIADRITKALPPAIMAKDIPLSGITDPSHERYKEAAEVRGLI
FT                   ETDPDVRTIYQTARGLEGLIRNAGVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYP
FT                   ACEAIGLLKMDFLGLRNLTIIGDAIDNVRANRGIDLDLESVPLDDKATYELLGRGDTLG
FT                   VFQLDGGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADRKNNRQAIKPIHP
FT                   ELEEPLREILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMGKKKREVLEKEFEG
FT                   FSDGMQANGFSPAAIKALWDTILPFADYAFNKSHAAGYGMVSYWTAYLKANYPAEYMAG
FT                   LLTSVGDDKDKAAVYLADCRKLGITVLPPDVNESGLNFASVGQDIRYGLGAVRNVGANV
FT                   VGSLLQTRNDKGKFTDFSDYLNKIDISACNKKVTESLIKAGAFDSLGHARKGLFLVHSD
FT                   AVDSVLGTKKAEALGQFDLFGSNDDGTGTADPVFTIKVPDDEWEDKHKLALEREMLGLY
FT                   VSGHPLNGVAHLLAAQVDTAIPAILDGDVPNDAQVRVGGILASVNRRVNKNGMPWASAQ
FT                   LEDLTGGIEVMFFPHTYSSYGADIVDDAVVLVNAKVAVRDDRIALIANDLTVPDFSNAE
FT                   VERPLAVSLPTRQCTFDKVSALKQVLARHPGTSQVHLRLISGDRITTLALDQSLRVTPS
FT                   PALMGDLKELLGPGCLGS"
FT   CDS             complement(20040..22076)
FT                   /transl_table=11
FT                   /gene="PPE21"
FT                   /locus_tag="Rv1548c"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1548c, (MTCY48.17), len: 678 aa. Member of the
FT                   Mycobacterium tuberculosis PPE family, similar to several
FT                   e.g. YHS6_MYCTU|P42611 hypothetical 50.6 kDa protein in
FT                   hsp65 3' region (517 aa), FASTA scores: opt:1142, E(): 0,
FT                   (40.6% identity in 616 aa overlap); also similar to
FT                   MTCY31.06c (54.9% identity in 381 aa overlap)."
FT                   /db_xref="GOA:Q10778"
FT                   /db_xref="InterPro:IPR002989"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10778"
FT                   /protein_id="CAE55401.1"
FT                   /translation="MNFSVLPPEINSALMFAGAGPGPMLAAASAWTGLAGDLGSAAASF
FT                   SAVTSQLATGSWQGPASAAMTGVAASYARWLTTAAAQAEQAAGQAQAAVSAFEAALAAT
FT                   VHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVYEQMWAADVAAMLGYHGEASAVAL
FT                   SLTPFTPSPSAAATPGGAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSANT
FT                   GSVNLGNANIGDLNLGSGNIGSYNLGGGNTGDLNPDSGNTGTLNWGSGNIGSYNLGGGN
FT                   LGSYNLGSGNTGDTNFGGGNTGNLNVGGGNTGNSNFGFGNTGNVNFGNGNTGDTNFGSG
FT                   NLGSGNIGFGNKGSHNIGFGNSGNNNIGFGLTGDNQIGFGALNSGSGNLGFGNSGNGNI
FT                   GFFNSGNNNIGMGNSGNGVGALSVEFGSSAERSSGFGNSGELSTGIGNSGQLSTGWFNS
FT                   ATTSTGWFNSGTTNTGWFNSGTTNTGIGNSGGNLVTGSMGLFNSGHTNTGSFNAGSMNT
FT                   GDFNSGNVNTGYFNSGNINTGFFNSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAG
FT                   TFNSGFDNNARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSVPTITGTANISG
FT                   FVNAGTSISGFFNFGSLMSGFANFDDEVSGYLNGDSRASGWIH"
FT   CDS             22253..22780
FT                   /transl_table=11
FT                   /gene="fadD11.1"
FT                   /locus_tag="Rv1549"
FT                   /standard_name="fadD11'"
FT                   /product="POSSIBLE FATTY-ACID-CoA LIGASE FADD11.1
FT                   (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)"
FT                   /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION."
FT                   /EC_number="6.2.1.-"
FT                   /note="Rv1549, (MTCY48.16c), len: 175 aa. Possible
FT                   fadD11.1, fatty-acid-CoA synthetase (EC 6.2.1.-), similar
FT                   to the N-terminus of many fatty-acid CoA synthetases e.g.
FT                   NP_147860.1|NC_000854 long-chain-fatty-acid--CoA ligase
FT                   from Aeropyrum pernix (651 aa); P31685|4CL2_SOLTU
FT                   4-coumarate--CoA ligase 2 (EC 6.2.1.12) from Solanum
FT                   tuberosum (Potato) (545 aa), FASTA scores: opt: 168, E():
FT                   4.4e-06, (30.4% identity in 112 aa overlap); etc. Possible
FT                   frameshift with respect to next ORF Rv1550|MTCY48.15c but
FT                   we can find no sequence error to account for this. Note
FT                   that previously known as fadD11'."
FT                   /db_xref="GOA:Q10777"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10777"
FT                   /protein_id="CAE55402.1"
FT                   /translation="MVAAPCFRVLRLWTYAHRCDLGHTDPLSRRTEMTTTERPTTMCEA
FT                   FQRTAVMDPDAVALRTPGGNQTMTWRDYAAQVRRVAAGLAGLGVRRGDTVSLMMANRIE
FT                   FYPLDVGAQHVGATSFSVYNTLPAEQLTYVFDNAGTKVVICEQQYVDRVRASGVPIEHI
FT                   VCVDGAPPARSR"
FT   CDS             22459..24174
FT                   /transl_table=11
FT                   /gene="fadD11"
FT                   /locus_tag="Rv1550"
FT                   /product="PROBABLE FATTY-ACID-CoA LIGASE FADD11
FT                   (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)"
FT                   /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION."
FT                   /EC_number="6.2.1.-"
FT                   /note="Rv1550, (MTCY48.15c), len: 571 aa. Probable fadD11,
FT                   fatty-acid-CoA synthetase (EC 6.2.1.-), similar, except in
FT                   N-terminus, to many e.g. SC6A5.39|T35430 probable
FT                   long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) from
FT                   Streptomyces coelicolor (612 aa); NP_301672.1|NC_002677
FT                   putative long-chain-fatty-acid-CoA ligase from
FT                   Mycobacterium leprae (600 aa); P44446|LCFH_HAEIN putative
FT                   long-chain-fatty-acid-CoA ligase from Haemophilus
FT                   influenzae (607 aa), FASTA scores: opt: 762, E(): 2.3e-38,
FT                   (34.4% identity in 436 aa overlap); etc. Contains PS00455
FT                   Putative AMP-binding domain signature. BELONGS TO THE
FT                   ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Possible
FT                   frameshift with respect to previous ORF Rv1549|MTCY48.16c
FT                   but we can find no sequence error to account for this."
FT                   /db_xref="GOA:Q10776"
FT                   /db_xref="HSSP:1LCI"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10776"
FT                   /protein_id="CAA98313.1"
FT                   /translation="MARLRGAGAAGRCRPGRFGSSARRHGLADDGEPDRVLPARRRCSA
FT                   RRRHLVFGVQHPARRAADLRVRQRGDQGGHLRATVRRSRSRQRCAHRTHRLRRWRAPGT
FT                   LSLTDLYAAASGDFFDFESTWRAVQPEDIVTLIYTSGTTGNPKGVEMTHANLLFEGYAI
FT                   DEVLGIRFGDRVTSFLPSAHIADRMTGLYLQEMFGTQVTAVADARTIAAALPDVRPTVW
FT                   GAVPRVWEKLKAGIEFTVARETDEMKRQALAWAMSVAGKRANALLAGESMSDQLVAEWA
FT                   KADELVLSKLRERLGFGELRWALSGAAPIPKETLAFFAGIGIPIAEIWGMSELSCVATA
FT                   SHPRDGRLGTVGKLLPGLQGKIAEDGEYLVRGPLVMKGYRKEPAKTAEAIDSDGWLHTG
FT                   DVFDIDSDGYLRVVDRKKELIINAAGKNMSPANIENTILAACPMVGVMMAIGDGRTYNT
FT                   ALLVFDADSLGPYAAQRGLDASPAALAADPEVIARIAAGVAEGNAKLSRVEQIKRFRIL
FT                   PTLWEPGGDEITLTMKLKRRRIAAKYSAEIEELYASELRPQVYEPAAVPSTQPA"
FT   misc_feature    22864..22899
FT                   /note="PS00455 Putative AMP-binding domain signature"
FT   CDS             24188..26053
FT                   /transl_table=11
FT                   /gene="plsB1"
FT                   /locus_tag="Rv1551"
FT                   /product="Possible acyltransferase plsB1"
FT                   /function="Thought to be involved in lipid metabolism."
FT                   /EC_number="2.-.-.-"
FT                   /note="Rv1551, (MT1601, MTCY48.14c), len: 621 aa. Possible
FT                   plsB1, acyltransferase (EC 2.-.-.-), similar to
FT                   PLSB_HAEIN|P44857 glycerol-3-phosphate acyltransferase from
FT                   Haemophilus influenzae (810 aa), FASTA scores: opt: 434,
FT                   E(): 6.2e-22, (27.6% identity in 395 aa overlap). Also
FT                   similar to Rv2482c|plsB2 Probable glycerol-3-phosphate
FT                   acyltransferase from Mycobacterium tuberculosis (789 aa)."
FT                   /db_xref="GOA:P65734"
FT                   /db_xref="InterPro:IPR002123"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65734"
FT                   /protein_id="CAA98312.1"
FT                   /translation="MTAREVGRIGLRKLLQRIGIVAESMTPLATDPVEVTQLLDARWYD
FT                   ERLRALADELGRDPDSVRAEAAGYLREMAASLDERAVQAWRGFSRWLMRAYDVLVDEDQ
FT                   ITQLRKLDRKATLAFAFSHRSYLDGMLLPEAILANRLSPALTFGGANLNFFPMGAWAKR
FT                   TGAIFIRRQTKDIPVYRFVLRAYAAQLVQNHVNLTWSIEGGRTRTGKLRPPVFGILRYI
FT                   TDAVDEIDGPEVYLVPTSIVYDQLHEVEAMTTEAYGAVKRPEDLRFLVRLARQQGERLG
FT                   RAYLDFGEPLPLRKRLQEMRADKSGTGSEIERIALDVEHRINRATPVTPTAVVSLALLG
FT                   ADRSLSISEVLATVRPLASYIAARNWAVAGAADLTNRSTIRWTLHQMVASGVVSVYDAG
FT                   TEAVWGIGEDQHLVAAFYRNTAIHILVDRAVAELALLAAAETTTNGSVSPATVRDEALS
FT                   LRDLLKFEFLFSGRAQFEKDLANEVLLIGSVVDTSKPAAAADVWRLLESADVLLAHLVL
FT                   RPFLDAYHIVADRLAAHEDDSFDEEGFLAECLQVGKQWELQRNIASAESRSMELFKTAL
FT                   RLARHRELVDGADATDIAKRRQQFADEIATATRRVNTIAELARRQ"
FT   CDS             26424..28175
FT                   /transl_table=11
FT                   /gene="frdA"
FT                   /locus_tag="Rv1552"
FT                   /product="PROBABLE FUMARATE REDUCTASE [FLAVOPROTEIN
FT                   SUBUNIT] FRDA (FUMARATE DEHYDROGENASE) (FUMARIC
FT                   HYDROGENASE)"
FT                   /function="INVOLVED IN INTERCONVERSION OF FUMARATE AND
FT                   SUCCINATE (ANAEROBIC RESPIRATION) [CATALYTIC ACTIVITY :
FT                   SUCCINATE + ACCEPTOR = FUMARATE + REDUCED ACCEPTOR]."
FT                   /EC_number="1.3.99.1"
FT                   /note="Rv1552, (MTCY48.13c), len: 583 aa. Probable frdA,
FT                   fumarate reductase, flavoprotein subunit (EC 1.3.99.1),
FT                   highly similar to others e.g. P00363|FRDA_ECOLI fumarate
FT                   reductase flavoprotein subunit from Escherichia coli strain
FT                   K12 (601 aa), FASTA scores: opt: 2102, E(): 0, (54.7%
FT                   identity in 585 aa overlap); NP_232284.1|NC_002505 fumarate
FT                   reductase, flavoprotein subunit from Vibrio cholerae (602
FT                   aa); frdA|NP_438995.1|NC_000907 fumarate reductase,
FT                   flavoprotein subunit from Haemophilus influenzae (599 aa);
FT                   etc. Contains PS00504 Fumarate reductase / succinate
FT                   dehydrogenase FAD-binding site. NOTE THAT FUMARATE
FT                   REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR
FT                   SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR
FT                   (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS
FT                   (Rv1554|frdC and Rv1555|frdD)."
FT                   /db_xref="GOA:P64174"
FT                   /db_xref="HSSP:1KF6"
FT                   /db_xref="InterPro:IPR014006"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64174"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA98311.1"
FT                   /translation="MTAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHT
FT                   VSAEGGAAAVTGDDDSLDEHAHDTVSGGDWLCDQDAVEAFVAEAPKELVQLEHWGCPWS
FT                   RKPDGRVAVRPFGGMKKLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTLLVD
FT                   DGRVCGLVAIELATGRIETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAP
FT                   LKDMEFVQYHPTGLPFTGILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSME
FT                   LGPRDRLSQAFVHEHNKGRTVDTPYGPVVYLDLRHLGADLIDAKLPFVRELCRDYQHID
FT                   PVVELVPVRPVVHYMMGGVHTDINGATTLPGLYAAGETACVSINGANRLGSNSLPELLV
FT                   FGARAGRAAADYAARHQKSDRGPSSAVRAQARTEALRLERELSRHGQGGERIADIRADM
FT                   QATLESAAGIYRDGPTLTKAVEEIRVLQERFATAGIDDHSRTFNTELTALLELSGMLDV
FT                   ALAIVESGLRREESRGAHQRTDFPNRDDEHFLAHTLVHRESDGTLRVGYLPVTITRWPP
FT                   GERVYGR"
FT   misc_feature    26547..26576
FT                   /note="PS00504 Fumarate reductase / succinate dehydrogenase
FT                   FAD-binding site"
FT   CDS             28178..28921
FT                   /transl_table=11
FT                   /gene="frdB"
FT                   /locus_tag="Rv1553"
FT                   /product="PROBABLE FUMARATE REDUCTASE [IRON-SULFUR SUBUNIT]
FT                   FRDB (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)"
FT                   /function="INVOLVED IN INTERCONVERSION OF FUMARATE AND
FT                   SUCCINATE (ANAEROBIC RESPIRATION) [CATALYTIC ACTIVITY :
FT                   SUCCINATE + ACCEPTOR = FUMARATE + REDUCED ACCEPTOR]."
FT                   /EC_number="1.3.99.1"
FT                   /note="Rv1553, (MTCY48.12c), len: 247 aa. Probable frdB,
FT                   fumarate reductase, iron-sulfur subunit (EC 1.3.99.1),
FT                   highly similar to others e.g. P00364|FRDB_ECOLI fumarate
FT                   reductase iron-sulfur protein from Escherichia coli strain
FT                   K12 (243 aa), FASTA scores: opt: 846, E(): 0, (50.0%
FT                   identity in 242 aa overlap); P20921|FRDB_PROVU FUMARATE
FT                   REDUCTASE IRON-SULFUR PROTEIN from Proteus vulgaris (245
FT                   aa); G64097 fumarate reductase (EC 1.3.99.1) iron-sulfur
FT                   protein from Haemophilus influenzae (276 aa); etc. Contains
FT                   PS00198 4Fe-4S ferredoxins, iron-sulfur binding region
FT                   signature. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN
FT                   ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN
FT                   (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO
FT                   HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD)."
FT                   /db_xref="GOA:Q10761"
FT                   /db_xref="HSSP:1KF6"
FT                   /db_xref="InterPro:IPR004489"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10761"
FT                   /protein_id="CAA98310.1"
FT                   /translation="MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDH
FT                   LDGTLSFRWSCRMGICGSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDLVV
FT                   DISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPVYA
FT                   LDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPA
FT                   GAIQRYKLTAATHALKKLLFPWGGG"
FT   misc_feature    28622..28657
FT                   /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding
FT                   region signature"
FT   CDS             28918..29298
FT                   /transl_table=11
FT                   /gene="frdC"
FT                   /locus_tag="Rv1554"
FT                   /product="PROBABLE FUMARATE REDUCTASE [MEMBRANE ANCHOR
FT                   SUBUNIT] FRDC (FUMARATE DEHYDROGENASE) (FUMARIC
FT                   HYDROGENASE)"
FT                   /function="INVOLVED IN INTERCONVERSION OF FUMARATE AND
FT                   SUCCINATE (ANAEROBIC RESPIRATION). THIS HYDROPHOBIC
FT                   COMPONENT MAY BE REQUIRED TO ANCHOR THE CATALYTIC
FT                   COMPONENTS OF THE FUMARATE REDUCTASE COMPLEX TO THE
FT                   CYTOPLASMIC MEMBRANE."
FT                   /EC_number="1.3.99.1"
FT                   /note="Rv1554, (MTCY48.11c), len 126 aa. Probable frdC,
FT                   fumarate reductase, membrane-anchor subunit (EC 1.3.99.1),
FT                   highly similar to others e.g. P03805|FRDC_ECOLI fumarate
FT                   reductase 15 kDa hydrophobic protein from Escherichia coli
FT                   strain K12 (131 aa), FASTA scores, opt: 268, E(): 3.9e-10,
FT                   (31.1% identity in 122 aa overlap); NP_458780.1|NC_003198
FT                   fumarate reductase complex subunit C; membrane anchor
FT                   polypeptide from Salmonella enterica subsp. enterica
FT                   serovar Typhi (131 aa); P20923|FRDC_PROVU FUMARATE
FT                   REDUCTASE 15 kDa HYDROPHOBIC PROTEIN from Proteus vulgaris
FT                   (131 aa); etc. NOTE THAT FUMARATE REDUCTASE FORMS PART OF
FT                   AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN
FT                   (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO
FT                   HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD)."
FT                   /db_xref="GOA:Q10762"
FT                   /db_xref="HSSP:1KF6"
FT                   /db_xref="InterPro:IPR003510"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10762"
FT                   /protein_id="CAA98309.1"
FT                   /translation="MSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLMLVLRA
FT                   VGAGGNSYQRFLDFSANPVVVVLNVVALSFLLLHAVTWFGSAPRAMVIQVRGRRVPARA
FT                   VLAGHYAAWLVVSVIVAWMVLS"
FT   CDS             29295..29672
FT                   /transl_table=11
FT                   /gene="frdD"
FT                   /locus_tag="Rv1555"
FT                   /product="PROBABLE FUMARATE REDUCTASE [MEMBRANE ANCHOR
FT                   SUBUNIT] FRDD (FUMARATE DEHYDROGENASE) (FUMARIC
FT                   HYDROGENASE)"
FT                   /function="INVOLVED IN INTERCONVERSION OF FUMARATE AND
FT                   SUCCINATE (ANAEROBIC RESPIRATION). THIS HYDROPHOBIC
FT                   COMPONENT MAY BE REQUIRED TO ANCHOR THE CATALYTIC
FT                   COMPONENTS OF THE FUMARATE REDUCTASE COMPLEX TO THE
FT                   CYTOPLASMIC MEMBRANE."
FT                   /EC_number="1.3.99.1"
FT                   /note="Rv1555, (MTCY48.10c), len: 125 aa. Probable frdD,
FT                   fumarate reductase, membrane-anchor subunit (EC 1.3.99.1),
FT                   similar to others e.g. P03806|FRDD_ECOLI fumarate reductase
FT                   13 kDa hydrophobic protein from Escherichia coli strain K12
FT                   (119 aa), FASTA scores: opt: 212, E(): 4.4e-08, (36.8%
FT                   identity in 106 aa overlap); etc. NOTE THAT FUMARATE
FT                   REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR
FT                   SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR
FT                   (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS
FT                   (Rv1554|frdC and Rv1555|frdD)."
FT                   /db_xref="GOA:P67643"
FT                   /db_xref="HSSP:1FUM"
FT                   /db_xref="InterPro:IPR003418"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67643"
FT                   /protein_id="CAA98308.1"
FT                   /translation="MTPSTSDARSRRRSAEPFLWLLFSAGGMVTALVAPVLLLLFGLAF
FT                   PLGWLDAPDHGHLLAMVRNPITKLVVLVLVVLALFHAAHRFRFVLDHGLQLGRFDRVIA
FT                   LWCYGMAVLGSATAGWMLLTM"
FT   CDS             29740..30348
FT                   /transl_table=11
FT                   /locus_tag="Rv1556"
FT                   /product="Possible regulatory protein"
FT                   /function="Possibly involved in a transcriptional
FT                   mechanism"
FT                   /note="Rv1556, (MTCY48.09c), len: 202 aa. Possible
FT                   regulatory protein, similar to X86780|SHGCPIR2|g987088
FT                   orfY, regulator of antibiotic transport complexes from
FT                   Streptomyces hygroscopicus (204 aa), FASTA score: opt: 251,
FT                   E(): 1.7e-10, (33.8% identity in 201 aa overlap) and
FT                   others."
FT                   /db_xref="GOA:P67436"
FT                   /db_xref="InterPro:IPR001647"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67436"
FT                   /protein_id="CAA98307.1"
FT                   /translation="MVGAVTQIADRPTDPSPWSPRETELLAVTLRLLQEHGYDRLTVDA
FT                   VAASARASKATVYRRWPSKAELVLAAFIEGIRQVAVPPNTGNLRDDLLRLGELICREVG
FT                   QHASTIRAVLVEVSRNPALNDVLQHQFVDHRKALIQYILQQAVDRGEISSAAISDELWD
FT                   LLPGYLIFRSIIPNRPPTQDTVQALVDDVILPSLTRSTG"
FT   CDS             30487..31680
FT                   /transl_table=11
FT                   /gene="mmpL6"
FT                   /locus_tag="Rv1557"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT
FT                   PROTEIN MMPL6"
FT                   /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID
FT                   TRANSPORT."
FT                   /note="Rv1557, (MTCY48.08c), len: 397 aa. Probable mmpL6,
FT                   conserved transmembrane transport protein (see citations
FT                   below). Member of RND superfamily, with strong similarity
FT                   to C-terminal part of members of large Mycobacterial
FT                   membrane protein family belonging to RND superfamily
FT                   including: mmpL1, mmpL2, mmpL3, etc. Probably truncated
FT                   (see Brosch et al., 2002). BELONGS TO THE MMPL FAMILY."
FT                   /db_xref="GOA:Q10773"
FT                   /db_xref="InterPro:IPR004869"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10773"
FT                   /protein_id="CAA98334.1"
FT                   /translation="MQGISVTGLVKRGWMVRSVFDTIDGIDQLGEQLASVTVTLDKLAA
FT                   IQPQLVALLPDEIASQQINRELALANYATMSGIYAQTAALIENAAAMGQAFDAAKNDDS
FT                   FYLPPEAFDNPDFQRGLKLFLSADGKAARMIISHEGDPATPEGISHIDAIKQAAHEAVK
FT                   GTPMAGAGIYLAGTAATFKDIQDGATYDLLIAGIAALSLILLIMMIITRSLVAALVIVG
FT                   TVALSLGASFGLSVLVWQHLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAG
FT                   LNTGIIRAMAGTGGVVTAAGLVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDTLVVRAF
FT                   MTPSIAVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGNDDPRTQVATHR"
FT   CDS             31690..32136
FT                   /transl_table=11
FT                   /locus_tag="Rv1558"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1558, (MTCY48.07c), len: 148 aa. Conserved
FT                   hypothetical protein, similar to other Mycobacterial
FT                   tuberculosis proteins e.g. P71854|MTCY03C7.09c|Rv3547 (151
FT                   aa), FASTA scores opt: 330, E(): 9.1e-17, (39.7% identity
FT                   in 151 aa overlap); also Q11057|Rv1261c (149 aa), and
FT                   O53328|Rv3178 (119 aa). Similar also to AF072709|AF072709_5
FT                   Hypothetical protein with a new amplifiable element AUD4
FT                   from Streptomyces lividans (149 aa), FASTA scores: opt:
FT                   695, E(): 0, (69.1% identity in 149 aa overlap)."
FT                   /db_xref="InterPro:IPR004378"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64875"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA98333.1"
FT                   /translation="MPLSGEYAPSPLDWSREQADTYMKSGGTEGTQLQGKPVILLTTVG
FT                   AKTGKLRKTPLMRVEHDGQYAIVASLGGAPKNPVWYHNVVKNPRVELQDGTVTGDYDAR
FT                   EVFGDEKAIWWQRAVAVWPDYASYQTKTDRQIPVFVLTPVRAGG"
FT   CDS             32171..33460
FT                   /transl_table=11
FT                   /gene="ilvA"
FT                   /locus_tag="Rv1559"
FT                   /product="Probable threonine dehydratase ilvA"
FT                   /function="INVOLVED IN ISOLEUCINE BIOSYNTHESIS (FIRST
FT                   STEP). CATALYZES THE FORMATION OF ALPHA-KETOBUTYRATE FROM
FT                   THREONINE IN A TWO STEP REACTION. THE FIRST STEP IS A
FT                   DEHYDRATION OF THREONINE, FOLLOWED BY REHYDRATION AND
FT                   LIBERATION OF AMMONIA [CATALYTIC ACTIVITY : L-THREONINE +
FT                   H(2)O = 2-OXOBUTANOATE + NH(3) + H(2)O]."
FT                   /EC_number="4.3.1.19"
FT                   /note="Rv1559, (MTCY48.06c), len: 429 aa. Probable ilvA,
FT                   threonine dehydratase (EC 4.2.1.16), biosynthetic protein,
FT                   similar to several e.g. THD1_CORGL|Q04513 threonine
FT                   dehydratase biosynthetic (436 aa), FASTA scores: opt: 1694,
FT                   E(): 0, (61.9% identity in 415 aa overlap). Contains
FT                   PS00165 Serine/threonine dehydratases pyridoxal-phosphate
FT                   attachment site."
FT                   /db_xref="GOA:P66897"
FT                   /db_xref="HSSP:1TDJ"
FT                   /db_xref="InterPro:IPR011820"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66897"
FT                   /protein_id="CAA98332.1"
FT                   /translation="MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLS
FT                   AITGATVYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFAYACRC
FT                   LGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATLVPP
FT                   FDDLRTIAGQGTIAVEVLGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEP
FT                   AGAAAMMAALAAGEPVTLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVC
FT                   TAMLDLYQNEGIIAEPAGALSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLV
FT                   HLGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAA
FT                   DLDGLLARMRATDIHVEALEPGSPAYRYLL"
FT   misc_feature    32339..32380
FT                   /note="PS00165 Serine/threonine dehydratases
FT                   pyridoxal-phosphate attachment site"
FT   CDS             33498..33716
FT                   /transl_table=11
FT                   /locus_tag="Rv1560"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1560, (MTCY48.05c), len: 72 aa. Conserved
FT                   hypothetical protein, part of a Mycobacterial tuberculosis
FT                   family of proteins e.g. Q10848|Rv2009|MTCY39.08c (80 aa),
FT                   FASTA score: (54.4% identity in 68 aa overlap);
FT                   Q10799|Rv2871|MTCY274.02 (85 aa); O50456|Rv1241|MTV006.13
FT                   (86 aa), O06243|Rv2132|MTCY270.36C (76 aa); etc."
FT                   /db_xref="InterPro:IPR019239"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64877"
FT                   /protein_id="CAA98331.1"
FT                   /translation="MYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSP
FT                   LSREFLLGLEGVGWEGDLDDLRSDRPD"
FT   CDS             33722..34126
FT                   /transl_table=11
FT                   /locus_tag="Rv1561"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1561, (MTCY48.04c), len: 134 aa. Conserved
FT                   hypothetical protein, similar to others from Mycobacterium
FT                   tuberculosis e.g. Q10847|Rv2010|MTCY39.07c (132 aa), FASTA
FT                   scores: (37.0% identity in 127 aa overlap); and
FT                   O06566|Rv1114|MTCY22G8.03 (124 aa)."
FT                   /db_xref="InterPro:IPR002716"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64879"
FT                   /protein_id="CAA98330.1"
FT                   /translation="MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEI
FT                   LSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAAGIYRAARRAGETVRSINDCLIAAL
FT                   AIRHGARIVHRDADFDVIARITNLQAASFR"
FT   CDS             complement(34143..35885)
FT                   /transl_table=11
FT                   /gene="treZ"
FT                   /locus_tag="Rv1562c"
FT                   /standard_name="glgZ"
FT                   /product="Maltooligosyltrehalose trehalohydrolase TreZ"
FT                   /function="INVOLVED IN TREHALOSE BIOSYNTHESIS (PROTECTIVE
FT                   EFFECT). Mycobacteria can produce trehalose from glucose
FT                   6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from
FT                   glycogen-like alpha(1-->4)-linked glucose polymers (the
FT                   TreY-TreZ pathway) and from maltose (the TreS pathway).
FT                   Seems to have additional alpha-glucosidase activity."
FT                   /note="Rv1562c, (MTCY48.03), len: 580 aa. treZ (previously
FT                   called glgZ), Maltooligosyltrehalose trehalohydrolase,
FT                   confirmed biochemically (see citation below). Similar to
FT                   Q44316|D63343 TREZ MALTOOLIGOSYL TREHALOSE TREHALOHYDROLASE
FT                   from ARTHROBACTER SP (598 aa), FASTA scores: opt: 2071,
FT                   E(): 0, (52.2% identity in 582 aa overlap); also similar to
FT                   1,4-alpha-glucan branching enzymes e.g. GLGB_BACST|P30538
FT                   (639 aa), FASTA scores: opt: 313, E(): 3.8e-13, (27.5%
FT                   identity in 462 aa overlap). Also similar to Mycobacterium
FT                   tuberculosis proteins Rv1326c|glgB, and Rv1563c treY
FT                   (previously glgY)."
FT                   /db_xref="GOA:Q10769"
FT                   /db_xref="HSSP:1EH9"
FT                   /db_xref="InterPro:IPR004193"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10769"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55403.1"
FT                   /translation="MPEFRVWAPKPALVRLDVNGAVHAMTRSADGWWHTTVAAPADARY
FT                   GYLLDDDPTVLPDPRSARQPDGVHARSQRWEPPGQFGAARTDTGWPGRSVEGAVIYELH
FT                   IGTFTTAGTFDAAIEKLDYLVDLGIDFVELMPVNSFAGTRGWGYDGVLWYSVHEPYGGP
FT                   DGLVRFIDACHARRLGVLIDAVFNHLGPSGNYLPRFGPYLSSASNPWGDGINIAGADSD
FT                   EVRHYIIDCALRWMRDFHADGLRLDAVHALVDTTAVHVLEELANATRWLSGQLGRPLSL
FT                   IAETDRNDPRLITRPSHGGYGITAQWNDDIHHAIHTAVSGERQGYYADFGSLATLAYTL
FT                   RNGYFHAGTYSSFRRRRHGRALDTSAIPATRLLAYTCTHDQVGNRALGDRPSQYLTGGQ
FT                   LAIKAALTLGSPYTAMLFMGEEWGASSPFQFFCSHPEPELAHSTVAGRKEEFAEHGWAA
FT                   DDIPDPQDPQTFQRCKLNWAEAGSGEHARLHRFYRDLIALRHNEADLADPWLDHLMVDY
FT                   DEQQRWVVMRRGQLMIACNLGAEPTCVPVSGELVLAWESPIIGDNSTELAAYSLAILRA
FT                   AEPA"
FT   CDS             complement(35878..38175)
FT                   /transl_table=11
FT                   /gene="treY"
FT                   /locus_tag="Rv1563c"
FT                   /standard_name="glgY"
FT                   /product="Maltooligosyltrehalose synthase TreY"
FT                   /function="INVOLVED IN TREHALOSE BIOSYNTHESIS (PROTECTIVE
FT                   EFFECT). Mycobacteria can produce trehalose from glucose
FT                   6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from
FT                   glycogen-like alpha(1-->4)-linked glucose polymers (the
FT                   TreY-TreZ pathway) and from maltose (the TreS pathway)."
FT                   /note="Rv1563c, (MTCY48.02), len: 765 aa. treY (previously
FT                   called glgY), maltooligosyl trehalose synthase, confirmed
FT                   biochemically (see citation below). Strong similarity to
FT                   Q44315|63343 TREY MALTOOLIGOSYL TREHALOSE SYNTHASE from
FT                   ARTHROBACTER SP (775 aa), fasta scores: opt: 1953, E(): 0;
FT                   (46.0% identity in 789 aa overlap). Some similarity to
FT                   alpha-amylases and to MTCY48.03 (30.2% identity in 215 aa
FT                   overlap). May catalyse conversion of maltodextrins to
FT                   maltooligosyl trehaloses. Also similar to Mycobacterium
FT                   tuberculosis glgB (Rv1326c), treZ (Rv1562c)."
FT                   /db_xref="GOA:Q10768"
FT                   /db_xref="HSSP:1IV8"
FT                   /db_xref="InterPro:IPR012767"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q10768"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55404.1"
FT                   /translation="MAFPVISTYRVQMRGRSNGFGFTFADAENLLDYLDDLGVSHLYLS
FT                   PILTAVGGSTHGYDVTDPTTVSPELGGSDGLARLSAAARSRGMGLIVDIVPSHVGVGKP
FT                   EQNAWWWDVLKFGRSSAYAEFFDIDWELGDGRIILPLLGSDSDVANLRVDGDLLRLGDL
FT                   ALPVAPGSGDGTGPAVHDRQHYRLVGWRHGLCGYRRFFSITSLAGLRQEDRAVFDASHA
FT                   EVARWFTEGLVDGVRVDHLDGLSDPSGYLAQLRELLGPNAWIVVEKILAVDEALEPTLP
FT                   VDGSTGYDVLREIGGVLVDPQGESPLTALVESAGVDYQEMPAMLADLKVHAAVHTLASE
FT                   LRRLRRCIAAAAGADHPLLPAAVAALLRHIGRYRCDYPGQAAVLPCALAETHSTTPQLA
FT                   PGLQLIAAAVARGGEPAVRLQQLCGAVSAKAVEDCMFYRDARLVSLNEVGGEPRRFGVG
FT                   AAEFHHRAATRARLWPRSMTTLSTHDTKRGEDVRARIGVLSQVPWLWAKFIGHAQAIAP
FT                   APDAVTGQFLWQNVFGVWPVSGEVSAALRGRLHTYAEKAIREAAWHTSWHNPNRAFEDD
FT                   VHGWLDLVLDGPLASELTGLVAHLNSHAESDALAAKLLALTVPGVPDVYQGSELWDDSL
FT                   VDPDNRRPVDYGTRRVALKALQHPKIRVLAAALRLRRTHPESFLGGAYHPVFAAGPAAD
FT                   HVVAFRRGDDILVAVTRWTVRLQQTGWDHTVLPLPDGSWTDALTGFTASGHTPAVELFA
FT                   DLPVVLLVRDNA"
FT   CDS             complement(38179..40344)
FT                   /transl_table=11
FT                   /gene="treX"
FT                   /locus_tag="Rv1564c"
FT                   /standard_name="glgX"
FT                   /product="Probable Maltooligosyltrehalose synthase TreX"
FT                   /function="POSSIBLY INVOLVED IN TREHALOSE BIOSYNTHESIS
FT                   (PROTECTIVE EFFECT). Mycobacteria can produce trehalose
FT                   from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB
FT                   pathway) from glycogen-like alpha(1-->4)-linked glucose
FT                   polymers (the TreY-TreZ pathway) and from maltose (the TreS
FT                   pathway)."
FT                   /note="Rv1564c, (MTCY48.01), len: 721 aa. Probable treX
FT                   (previously called glgX), Maltooligosyltrehalose synthase.
FT                   Strong similarity to D83245|g1890053 treX, glycogen
FT                   debranching enzyme (glgX) from Sulfolobus acidocaldarius
FT                   (713 aa), FASTA score: opt: 2396, E(): 0, (48.4% identity
FT                   in 709 aa overlap); similar to GLGX_HAEIN|P45178 glycogen
FT                   operon protein glgx (659 aa), FASTA scores: opt: 1512, E():
FT                   0, (42.3% identity in 645 aa overlap)."
FT                   /db_xref="GOA:P0A4Y4"
FT                   /db_xref="HSSP:1BF2"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A4Y4"
FT                   /protein_id="CAE55405.1"
FT                   /translation="MSSNNAGESDGTGPALPTVWPGNAYPLGATYDGAGTNFSLFSEIA
FT                   EKVELCLIDEDGVESRIPLDEVDGYVWHAYLPNITPGQRYGFRVHGPFDPAAGHRCDPS
FT                   KLLLDPYGKSFHGDFTFGQALYSYDVNAVDPDSTPPMVDSLGHTMTSVVINPFFDWAYD
FT                   RSPRTPYHETVIYEAHVKGMTQTHPSIPPELRGTYAGLAHPVIIDHLNELNVTAVELMP
FT                   VHQFLHDSRLLDLGLRNYWGYNTFGFFAPHHQYASTRQAGSAVAEFKTMVRSLHEAGIE
FT                   VILDVVYNHTAEGNHLGPTINFRGIDNTAYYRLMDHDLRFYKDFTGTGNSLNARHPHTL
FT                   QLIMDSLRYWVIEMHVDGFRFDLASTLARELHDVDRLSAFFDLVQQDPVVSQVKLIAEP
FT                   WDVGEGGYQVGNFPGLWTEWNGKYRDTVRDYWRGEPATLGEFASRLTGSSDLYEATGRR
FT                   PSASINFVTAHDGFTLNDLVSYNDKHNEANGENNRDGESYNRSWNCGVEGPTDDPDILA
FT                   LRARQMRNMWATLMVSQGTPMIAHGDEIGRTQYGNNNVYCQDSELSWMDWSLVDKNADL
FT                   LAFARKATTLRKNHKVFRRRRFFEGEPIRSGDEVRDIAWLTPSGREMTHEDWGRGFDRC
FT                   VAVFLNGEAITAPDARGERVVDDSFLLCFNAHDHDVEFVMPHDGYAQQWTGELDTNDPV
FT                   GDIDLTVTATDTFSVPARSLLVLRKTL"
FT   CDS             complement(40383..42572)
FT                   /transl_table=11
FT                   /locus_tag="Rv1565c"
FT                   /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1565c, (MTCY336.38), len: 729 aa. Conserved
FT                   hypothetical membrane protein, some similarity to O05402
FT                   HYPOTHETICAL 72.2 kDa PROTEIN from Bacillus subtilis (634
FT                   aa), FASTA results: opt: 384, E(): 4.8e-17, (29.1% identity
FT                   in 378 aa overlap); and to Y392_HAEIN|P43993 hypothetical
FT                   protein hi0392 from H. influenzae (245 aa), FASTA results:
FT                   opt: 265, E(): 5.5e-10, (28.3% identity in 247 aa overlap).
FT                   C-terminal half equivalent to AL049478|MLCL458_19 (274 aa)
FT                   (78.5% identity in 274 aa overlap). Also similar to
FT                   Mycobacterium tuberculosis hypothetical proteins Rv0111,
FT                   Rv0228, Rv1254, Rv0517. N-terminal half hydrophobic.
FT                   TBparse score is 0.930."
FT                   /db_xref="GOA:O06625"
FT                   /db_xref="InterPro:IPR002656"
FT                   /db_xref="UniProtKB/TrEMBL:O06625"
FT                   /protein_id="CAB09072.1"
FT                   /translation="MLTLSPPRPPALTPEPALPPVTMGTRTTGFYRHDLDGLRGVAIAL
FT                   VAVFHVWFGRVSGGVDVFLALSGFFFGGKILRAALNPDLSLSPIAEVIRLIRRLLPALV
FT                   VVLAGCALLTIAIQPQTRWEAFANQSLASLGYYQNWELASTVSNYLRAGEAVSPLQHIW
FT                   SMSVQGQFYLAFLLLVAGCAYLLRRLFRGPRAPYLRTMFVVLLSTLTLASFIYAIVAHH
FT                   AYQATAYYNTFARAWELLAGALVGAVVPHVRWPMWLRTAVATAALAAILSCGALIDGVK
FT                   EFPGPWALVPVGATMLMILAGANRQGHPGTRDRLPLPNRLLATAPLVALGAMAYSWYLW
FT                   HWPLLIFWLSYTGHRHANFVEGAAVLLVSGLLAYLTTRLVEDPLRYRAPAGVRSPAAVP
FT                   PIPWRLRLRRPTIVLGSVVALLGVALTATSFTWREHVIVQRAAGKELSGLSSRDYPGAR
FT                   ALIDHVRVPKLRMRPTVLEVRHDLPTSTKDGCISDFVNPAIINCTYGDVDAPRTIALAG
FT                   GSHAEHWLTALDLLGRMHHFKVVTYLKMGCPLSTEEVPLIMGNNAPYPQCHQWVQAAMA
FT                   KLVADHPDYVFTTSTRPWNIKPGDVMPATYVGIWQTFADNNIPVLAMRDTPWLVKDGQP
FT                   FIPADCLAKGGNPQSCGIARSKVLVDRNPTLDFVARFPLLKPLDMSDAICRTDTCRAVE
FT                   GNVLVYRDSHHLTPTYMRTMTSELGRQIAANTDWW"
FT   CDS             complement(42671..43363)
FT                   /transl_table=11
FT                   /locus_tag="Rv1566c"
FT                   /product="Possible inv protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1566c, (MTCY336.37), len: 230 aa. Possible inv
FT                   protein, probably exported as has QQAPV repeats at
FT                   C-terminus. Similar to Q49634 inv protein from
FT                   Mycobacterium leprae (246 aa), FASTA scores: opt: 957, E():
FT                   0, (70.0% identity in 207 aa overlap); also to putative
FT                   invasins 1,2 (O07390, O07391) from Mycobacterium avium.
FT                   Slightly similar to C-terminus of P60_LISMO|P21171 Listeria
FT                   invasion-associated protein p60 precursor. Also similar to
FT                   Mycobacterium tuberculosis p60 homologues Rv1477, Rv1478,
FT                   Rv0024, Rv2190c. TBparse score is 0.890."
FT                   /db_xref="InterPro:IPR000064"
FT                   /db_xref="UniProtKB/TrEMBL:O06624"
FT                   /protein_id="CAB09071.1"
FT                   /translation="MKRSMKSGSFAIGLAMMLAPMVAAPGLAAADPATRPVDYQQITDV
FT                   VIARGLSQRGVPFSWAGGGISGPTRGTGTGINTVGFDASGLIQYAYAGAGLKLPRSSGQ
FT                   MYKVGQKVLPQQARKGDLIFYGPEGTQSVALYLGKGQMLEVGDVVQVSPVRTNGMTPYL
FT                   VRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPP
FT                   PFGTARSR"
FT   CDS             complement(43603..43887)
FT                   /transl_table=11
FT                   /locus_tag="Rv1567c"
FT                   /product="Probable hypothetical membrane protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1567c, (MTCY336.36), len: 94 aa. Probable membrane
FT                   protein. TBparse score is 0.915."
FT                   /db_xref="UniProtKB/TrEMBL:O06623"
FT                   /protein_id="CAB09070.1"
FT                   /translation="MVTMTSWPSRLFAFTDNVCPPDACPLVPFGVNYYIYPVMWGGIGA
FT                   AIATAVIGPFVSMLKGWYMSFWPIISIAVITVTSIAGYAIAGFSERYWH"
FT   CDS             44135..45448
FT                   /transl_table=11
FT                   /gene="bioA"
FT                   /locus_tag="Rv1568"
FT                   /product="PROBABLE
FT                   ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
FT                   BIOA"
FT                   /function="INVOLVED IN BIOCONVERSION OF PIMELATE INTO
FT                   DETHIOBIOTIN [CATALYTIC ACTIVITY : S-ADENOSYL-L-METHIONINE
FT                   + 8-AMINO-7- OXONONANOATE =
FT                   S-ADENOSYL-4-METHYLTHIO-2-OXOBUTANOATE + 7,8-
FT                   DIAMINONONANOATE]. SUPPOSED INVOLVED IN STATIONARY-PHASE
FT                   SURVIVAL."
FT                   /EC_number="2.6.1.62"
FT                   /note="Rv1568, (MTCY336.35c), len: 437 aa. Probable bioA,
FT                   adenosylmethionine-8-amino-7-oxononanoate aminotransferase
FT                   (EC 2.6.1.62), equivalent to a predicted homologous protein
FT                   from Mycobacterium smegmatis (see citation below). Highly
FT                   similar to BIOA_MYCLE|P4548 from Mycobacterium leprae (436
FT                   aa), FASTA results: opt: 2534, E(): 0, (85.1% identity in
FT                   436 aa overlap). Also similar to other Mycobacterium
FT                   tuberculosis proteins e.g. MTCY227.12c (449 aa), FASTA
FT                   score: E(): 3.5e-16, (29.5% identity in 421 aa overlap).
FT                   Contains aminotransferases class-III pyridoxal-phosphate
FT                   attachment site (PS00600). TBparse score is 0.874. BELONGS
FT                   TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT
FT                   AMINOTRANSFERASES."
FT                   /db_xref="GOA:P0A4X6"
FT                   /db_xref="InterPro:IPR015421"
FT                   /db_xref="PDB:3BV0"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A4X6"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09069.1"
FT                   /translation="MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAW
FT                   LTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLA
FT                   KLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFL
FT                   AMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPV
FT                   VQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCV
FT                   GKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQD
FT                   WRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWL
FT                   RPFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP"
FT   misc_feature    44885..44998
FT                   /note="PS00600 Aminotransferases class-III
FT                   pyridoxal-phosphate attachment site"
FT   CDS             45445..46605
FT                   /transl_table=11
FT                   /gene="bioF1"
FT                   /locus_tag="Rv1569"
FT                   /product="PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF1
FT                   (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE)
FT                   (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP
FT                   SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE)"
FT                   /function="INVOLVED IN BIOTIN BIOSYNTHESIS (AT THE FIRST
FT                   STEP) [CATALYTIC ACTIVITY: 6-CARBOXYHEXANOYL-CoA +
FT                   L-ALANINE = 8-AMINO-7-OXONONANOATE + CoA + CO2]."
FT                   /EC_number="2.3.1.47"
FT                   /note="Rv1569, (MTCY336.34c), len: 386 aa. Probable bioF1,
FT                   8-amino-7-oxononanoate synthase (EC 2.3.1.47), highly
FT                   similar to BIOF_MYCLE|P45487 from Mycobacterium leprae (385
FT                   aa), FASTA results: opt: 1971, E(): 0, (80.1% identity in
FT                   381 aa overlap). Also similar to BIOF2|Rv0032|MTCY10H4.32
FT                   POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE from Mycobacterium
FT                   tuberculosis (771 aa), FASTA score: E(): 5.5e-29, (37.4%
FT                   identity in 393 aa overlap). Contains aminotransferases
FT                   class-II pyridoxal-phosphate attachment site (PS00599).
FT                   BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT
FT                   AMINOTRANSFERASES."
FT                   /db_xref="GOA:P0A4X4"
FT                   /db_xref="HSSP:1BS0"
FT                   /db_xref="InterPro:IPR015421"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A4X4"
FT                   /protein_id="CAE55406.1"
FT                   /translation="MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDL
FT                   ASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGL
FT                   LFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAAL
FT                   RSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYE
FT                   LGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARA
FT                   ALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGV
FT                   KVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR"
FT   misc_feature    46150..46179
FT                   /note="PS00599 Aminotransferases class-II
FT                   pyridoxal-phosphate attachment site"
FT   CDS             46602..47282
FT                   /transl_table=11
FT                   /gene="bioD"
FT                   /locus_tag="Rv1570"
FT                   /product="Probable dethiobiotin synthetase bioD"
FT                   /function="INVOLVED IN BIOCONVERSION OF PIMELATE INTO
FT                   DETHIOBIOTIN [CATALYTIC ACTIVITY : ATP +
FT                   7,8-DIAMINONONANOATE + CO(2) = ADP + PHOSPHATE +
FT                   DETHIOBIOTIN]"
FT                   /EC_number="6.3.3.3"
FT                   /note="Rv1570, (MTCY336.33c), len: 226 aa. Probable bioD,
FT                   dethiobiotin synthetase (EC 6.3.3.3). Similar to many e.g.
FT                   BIOD_MYCLE|P45486 from Mycobacterium leprae (223 aa), FASTA
FT                   results: opt: 1059, E(): 0, (74.8% identity in 222 aa
FT                   overlap). BELONGS TO THE DETHIOBIOTIN SYNTHETASE FAMILY."
FT                   /db_xref="GOA:O06620"
FT                   /db_xref="InterPro:IPR004472"
FT                   /db_xref="PDB:3FGN"
FT                   /db_xref="UniProtKB/Swiss-Prot:O06620"
FT                   /protein_id="CAB09067.1"
FT                   /translation="MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTAR
FT                   GDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRL
FT                   TLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSC
FT                   AGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVA
FT                   GLVG"
FT   CDS             47282..47791
FT                   /transl_table=11
FT                   /locus_tag="Rv1571"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1571, (MTCY336.32c), len: 169 aa. Conserved
FT                   hypothetical protein, similar at N-terminal region to
FT                   Q49625|LEPB1170_C3_227 hypothetical protein from
FT                   Mycobacterium leprae (104 aa), FASTA results: opt: 473,
FT                   E(): 3.9e-24, (74.5% identity in 102 aa overlap). Identical
FT                   to O06619|AF041819|AF041819_6 Mycobacterium bovis BCG (169
FT                   aa). TBparse score is 0.871."
FT                   /db_xref="GOA:O06619"
FT                   /db_xref="UniProtKB/TrEMBL:O06619"
FT                   /protein_id="CAB09066.1"
FT                   /translation="MVHSIELVFDSDTEAAIRRIWAGLAAAGIPSQAPASRPHVSLAVA
FT                   ERIAPEVDEPLGAVARRLPLDCVIGAPVLFGRANVVFTRLVVPTSELLALHAEVHRLCG
FT                   PHLAPAPMANSLPGQWTAHVTLARRVGGHQLGRALRIAGRPSRIDGRFAGLRRWDGNTR
FT                   AEYLLG"
FT   CDS             complement(47937..48041)
FT                   /transl_table=11
FT                   /locus_tag="Rv1572c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1572c, (MTCY336.31B), len: 34 aa. Partial ORF,
FT                   part of REP13E12 repeat element; 3' end of Rv1587c
FT                   (MTCY336.17) after phage-like element (see citation below).
FT                   Similar to C-terminal ends of other REP13E12 repeat
FT                   elements e.g. Rv1148, Rv1945, Rv3467, etc. Length extended
FT                   since first submission (+7 aa)."
FT                   /db_xref="UniProtKB/TrEMBL:O06618"
FT                   /protein_id="CAB09065.2"
FT                   /translation="MECSSAVHGQPRTNTFHHHEKLLRHNDEDNHDDP"
FT   repeat_region   complement(48009..48020)
FT                   /note="12 bp direct repeat 1, ccacggccaacc, flanking
FT                   phage-like element, second site at 1788514..1788525"
FT   CDS             48057..48467
FT                   /transl_table=11
FT                   /locus_tag="Rv1573"
FT                   /product="Probable phiRV1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1573, (MTCY336.31c), len: 136 aa. Probable phiRv1
FT                   phage protein (see citation below). TBparse score is
FT                   0.872."
FT                   /db_xref="UniProtKB/TrEMBL:O06617"
FT                   /protein_id="CAB09064.1"
FT                   /translation="MTTTPARFNHLVTVTDLETGDRAVCDRDQVAETIRAWFPDAPLEV
FT                   REALVRLQAALNRHEHTGELEAFLRISVEHADAAGGDECGPAILAGRSGPEQAAINRQL
FT                   GLAGDDEPDGDDTPPWSRMIGLGGGSPAEDER"
FT   CDS             48673..48984
FT                   /transl_table=11
FT                   /locus_tag="Rv1574"
FT                   /product="Probable phiRV1 phage related protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1574, (MTCY336.30), len: 103 aa. Probable phiRV1
FT                   phage related protein (see citation below); some similarity
FT                   to N-terminus of Rv1575|MTCY441.17 Probable phiRV1 phage
FT                   protein (166 aa), E(): 1.5e-06; and Rv2647|MTCY336.29c
FT                   Probable phiRV2 phage protein, E(): 3.5e-05. Helix turn
FT                   helix motif present at aa 14-35 (+3.61 SD)."
FT                   /db_xref="UniProtKB/TrEMBL:O06616"
FT                   /protein_id="CAB09063.1"
FT                   /translation="MGYKPESERHSTKTDTAIGAALGISAGTYRRLKRIDNATHSDDKE
FT                   IRRFAEKQMAPLVAGSPSWNARKPRSANARVVASVHRSPMPALVPWNQSRLSATLTRR"
FT   repeat_region   complement(48702..48790)
FT                   /note="89 bp direct repeat 2, first copy at
FT                   1780485..1780573,
FT                   GGGTTGCGTTGTCGATTCGTTTGAGCCGCCGGTAGGTGCCGGCGGAGATGCCGAGGG
FT                   CTGCGCCGATAGCAGTGTCTGTTTTCGTCGAA"
FT   CDS             48942..49442
FT                   /transl_table=11
FT                   /locus_tag="Rv1575"
FT                   /product="Probable phiRV1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1575, (MTCY336.29c), len: 166 aa. Probable phiRV1
FT                   phage protein (see citation below), showing similarity in
FT                   N-terminal part to Rv1574|MTCY336.30c Probable phiRV1 phage
FT                   protein (103 aa), FASTA score: opt: 375, E(): 3.8e-16,
FT                   (60.2% identity in 103 aa overlap); and Rv2647 Probable
FT                   phiRV2 phage protein. Start changed since first submission
FT                   (+49 aa)."
FT                   /db_xref="UniProtKB/TrEMBL:O06615"
FT                   /protein_id="CAB09062.2"
FT                   /translation="MEPKPSQRHTDKEVGAALGISAGTYKRLKRIDNATRSDDKEIRLF
FT                   AEKQMAPLAAGSPSWNGRKPSSGNRKAATMAARLDILAWGPWAPSQNRSVVRRKQTLLS
FT                   AQPSASPPAPTGGSNESTTQPAASWRVGGPAPLSRGRPRLALSYLRGSLHLQNSKRVAH
FT                   QHI"
FT   repeat_region   complement(49228..49316)
FT                   /note="89 bp direct repeat 1, second copy at
FT                   1779959..1780047,
FT                   GGGTTGCGTTGTCGATTCGTTTGAGCCGCCGGTAGGTGCCGGCGGAGATGCCGAGGG
FT                   CTGCGCCGATAGCAGTGTCTGTTTTCGTCGAA. Many repeats, both direct
FT                   and inverted, in this region"
FT   CDS             complement(49386..50807)
FT                   /transl_table=11
FT                   /locus_tag="Rv1576c"
FT                   /product="Probable phiRV1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1576c, (MTCY336.28), len: 473 aa. Probable phiRV1
FT                   phage protein (capsid subunit) (see citation below). Highly
FT                   similar to hypothetical Mycobacterium tuberculosis protein
FT                   Rv2650c|MTCY441.19 phiRV2 phage related protein, FASTA
FT                   scores: opt: 2782, E(): 0, (89.1% identity in 468 aa
FT                   overlap). TBparse score is 0.909."
FT                   /db_xref="InterPro:IPR006444"
FT                   /db_xref="UniProtKB/TrEMBL:O06614"
FT                   /protein_id="CAB09061.1"
FT                   /translation="MTEFDDIKNLSLPETRDAAKQLLDSVAGDLTGEAAQRFQALTRHA
FT                   EELRAEQRRRGREAEEALRRYRAGELRVVPGAPTGGDDGDAPPGNSLRDTAFRTLDSCV
FT                   RDGLMSSRAAETAETLCRTGPPQSTSWAQRWLAATGSRDYLGAFVKRVSNPVAGHTVWT
FT                   DREAAAWREAAAVAAEQRAMGLVDTQGGFLIPAALDPAILLSGDGSTNPIRQVARVVQT
FT                   TSEIWRGVTSEGAEARWYSEAQEVSDDSPALAQPAVPNYRGSCWIPFSIELEGDAASFV
FT                   GEIGKILADSVEQLQAAAFVNGSGNGEPTGFVSALTGTSDQVVVGAGSEAIVAADVYAL
FT                   QSALPPRFQASAAFAANLSTINTLRQAETSNGALKFPSLHDSPPMLAGKSVLEVSHMDT
FT                   VDSAVTATNHPLVLGDWKQFLIGDRVGSMVELVPHLFGPNRRPTGQRGFFAWFRVGSDV
FT                   LVRNAFRVLKVETTA"
FT   CDS             complement(50815..51327)
FT                   /transl_table=11
FT                   /locus_tag="Rv1577c"
FT                   /product="Probable phiRv1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1577c, (MTCY336.27), len: 170 aa. Probable phiRv1
FT                   phage protein (prohead protease) (see citation below).
FT                   Highly similar to hypothetical protein Rv2651c|MTCY441.20c
FT                   phiRV2 prohead protease, FASTA scores: E(): 0, (89.3%
FT                   identity in 169 aa overlap). Some similarity to
FT                   VP4_BPHK7|P49860 putative bacteriophage HK97 prohead
FT                   protease (gp4) (225 aa), FASTA results: opt: 176, E():
FT                   1.3e-05, (27.3% identity in 165 aa overlap). TBparse score
FT                   is 0.912."
FT                   /db_xref="InterPro:IPR006433"
FT                   /db_xref="UniProtKB/TrEMBL:O06613"
FT                   /protein_id="CAB09060.1"
FT                   /translation="MAELRSGEGRTVHGTIVPYNEATTVRDFDGEFQEMFAPGAFRRSI
FT                   AERGHKLKLLVSHDARTRYPVGRAVELREEPHGLFGAFEIADTPDGDEALANVKAGVVD
FT                   SFSVGFRPIRDRREGDVLVRVEAALLEVSLTGVPAYSGAQIAGVRAESLTVVSRSTAEA
FT                   WLSLLDW"
FT   CDS             complement(51501..51971)
FT                   /transl_table=11
FT                   /locus_tag="Rv1578c"
FT                   /product="Probable phiRv1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1578c, (MTCY336.26), len: 156 aa. Probable phiRv1
FT                   phage protein (terminase) (see citation below), highly
FT                   similar to Rv2652c|MTCY441.21c phiRV2 phage protein from
FT                   Mycobacterium tuberculosis, FASTA scores: E(): 4.8e-22,
FT                   (48.1% identity in 156 aa overlap). Also similar to
FT                   X65555|ARP3COS_1 hypothetical protein (cos site) -
FT                   actinophage RP3 (210 aa), FASTA scores: opt: 373, E():
FT                   6.5e-17, (50.0% identity in 114 aa overlap). Contains MIP
FT                   family signature (PS00221). TBparse score is 0.902."
FT                   /db_xref="InterPro:IPR006448"
FT                   /db_xref="UniProtKB/TrEMBL:O06612"
FT                   /protein_id="CAB09059.1"
FT                   /translation="MPRPPKPARLKLVEGRSPGRDSGGRKVPESPKFIRQAPDAPDWLD
FT                   AEALAEWRRVAPTLERLDLLKPEDRALLSAYCETWSVYVAAVQRVRAEGLTITSPKSGV
FT                   VHRNPAVTVAETARMHLLRLASEFGLTPAAEQRLAVAPGDDGDGLNPFAPDR"
FT   misc_feature    complement(51630..51656)
FT                   /note="PS00221 MIP family signature"
FT   CDS             complement(52052..52366)
FT                   /transl_table=11
FT                   /locus_tag="Rv1579c"
FT                   /product="Probable phiRv1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1579c, (MTCY336.25), len: 104 aa. Probable phiRv1
FT                   phage protein (see citation below). TBparse score is
FT                   0.921."
FT                   /db_xref="UniProtKB/TrEMBL:O06611"
FT                   /protein_id="CAB09090.1"
FT                   /translation="MTPINRPLTNDERQLMHELAVQVVCSQTGCSPDAAVEALESFAKD
FT                   GTLILRGDTENAYLEAGGNVLVHADRDWLAFHASYPGNDPLRDARPIEQDDDQGAGSPS
FT                   "
FT   CDS             complement(52363..52635)
FT                   /transl_table=11
FT                   /locus_tag="Rv1580c"
FT                   /product="Probable phiRv1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1580c, (MTCY336.24), len: 90 aa. Probable phiRv1
FT                   phage protein (see citation below). TBparse score is
FT                   0.878."
FT                   /db_xref="UniProtKB/TrEMBL:O06610"
FT                   /protein_id="CAB09089.1"
FT                   /translation="MAETPDHAELRRRIADMAFNADVGMATCKRCGDAVPYIILPNLQT
FT                   GEPVMGVADNKWKRANCPVDVGKPCPFLIAEGVADSTDDTIEVDQ"
FT   CDS             complement(52649..53044)
FT                   /transl_table=11
FT                   /locus_tag="Rv1581c"
FT                   /product="Probable phiRv1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1581c, (MTCY336.23), len: 131 aa. Probable phiRv1
FT                   phage protein (see citation below). TBparse score is
FT                   0.928."
FT                   /db_xref="UniProtKB/TrEMBL:O06609"
FT                   /protein_id="CAB09088.1"
FT                   /translation="MTAVAITPASGGRHSVRFAYDSAIVSLIKSTIPAYARSWSAHTRC
FT                   WFIDADWTPLLAAELRYHGHTVTGPADPAQQQCTDWAKALFRAVGPQRTPAVYRALSKV
FT                   LHPDAPTGCPILQQQLNAARTALTNPA"
FT   CDS             complement(53240..54655)
FT                   /transl_table=11
FT                   /locus_tag="Rv1582c"
FT                   /product="Probable phiRv1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1582c, (MTCY336.22), len: 471 aa. Probable phiRv1
FT                   phage protein (see citation below). N-terminus is similar
FT                   to C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519
FT                   aa), FASTA scores: opt: 331, E(): 6.5e-15, (28.5% identity
FT                   in 235 aa overlap); and C-terminus to whole of Q38031 ORF10
FT                   of Bacteriophage phi-C31 (202 aa), FASTA scores: opt: 353,
FT                   E(): 1e-16, (31.1% identity in 190 aa overlap). Also
FT                   similar to part of AB016282|AB016282_42 Bacteriophage
FT                   phi-105 (806 aa), FASTA scores: opt: 790, E(): 0, (32.7%
FT                   identity in 459 aa overlap). Similarity to other phage
FT                   proteins described as putative DNA-polymerase or
FT                   DNA-primase. Also slightly similar to MTCY441.24c, FASTA
FT                   scores: E(): 0.0055, (36.0% identity in 75 aa overlap)."
FT                   /db_xref="InterPro:IPR014818"
FT                   /db_xref="UniProtKB/TrEMBL:O06608"
FT                   /protein_id="CAB09087.1"
FT                   /translation="MADIPYGTDYPDAPWIDRDGHVLIDDGGKPTQVHRGQARIAYRLA
FT                   ERYQDKLLHVAGIGWHSWDGRRWAADDRGEAKRAVLAELRQALSDSLNDKELRADVRKC
FT                   ESASGVAGVLDLAAALVPFAATVADLDSDPHLLNVANGTLDLHTLKLRPHAPADRITKI
FT                   CRGAYQSDTESPLWQAFLTRVLPDEGVRGFVQRLAGVGLLGTVREHVLAILIGVGANGK
FT                   SVFDKAIRYALGDYACTAEPDLFMHRENAHPTGEMDLRGVRWVAVSESEKDRRLAESTI
FT                   KRLTGGDTIRARKMRQDFVEFTPSHTPLLITNHLPRVPGDDTAIWRRIRVVPFEVVIPA
FT                   DEQDRELDARLQLEADSILSWAVAGWSDYQRIGLSQPDAVLAATSNYREDSDTIKRFID
FT                   DECVTSSPVLKATTTHLFEAWQRWRVQEGVPEISRKAFGQSLDTHGYPVTDKARDGRWR
FT                   AGIAVRGADDFDD"
FT   CDS             complement(54655..55053)
FT                   /transl_table=11
FT                   /locus_tag="Rv1583c"
FT                   /product="Probable phiRv1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1583c, (MTCY336.21), len: 132 aa. Probable phiRv1
FT                   phage protein (see citation below), highly similar to
FT                   Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa), FASTA
FT                   score: E(): 1.3e-33, (81.7% identity in 131 aa overlap).
FT                   TBparse score is 0.912."
FT                   /db_xref="UniProtKB/Swiss-Prot:O06607"
FT                   /protein_id="CAB09086.1"
FT                   /translation="MTAGAGGSPPTRRCPATEDRAPATVATPSSADPTASRAVSWWSVH
FT                   EHVAPVLDAAGSWPMAGTPAWRQLDDADPRKWAAICDAARHWALRVETCQEAMAQASRD
FT                   VSAAADWPGIAREIVRRRGVYIPRAGVA"
FT   CDS             complement(55050..55271)
FT                   /transl_table=11
FT                   /locus_tag="Rv1584c"
FT                   /product="Possible phiRv1 phage protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1584c, (MTCY336.20), len: 73 aa. Possible phiRv1
FT                   phage protein (putative excisionase) (see citation below).
FT                   TBparse score is 0.883."
FT                   /db_xref="UniProtKB/TrEMBL:O06606"
FT                   /protein_id="CAB09085.1"
FT                   /translation="MSTIYHHRGRVAALSRSRASDDPEFIAAKTDLVAANIADYLIRTL
FT                   AAAPPLTDEQRTRLAELLRPVRRSGGAR"
FT   CDS             complement(55327..55842)
FT                   /transl_table=11
FT                   /locus_tag="Rv1585c"
FT                   /product="Possible phage phiRv1 protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1585c, (MTCY336.19), len: 171 aa. Possible phage
FT                   phiRv1 protein (see Hatfull 2000). TBparse score is 0.926."
FT                   /db_xref="UniProtKB/TrEMBL:O06605"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09084.1"
FT                   /translation="MSRHHNIVIVCDHGRKGDGRIEHERCDLVAPIIWVDETQGWLPQA
FT                   PAVATLLDDDNQPRAVIGLPPNESRLRPEMRRDGWVRLHWEFACLRYGAAGVRTCEQRP
FT                   VRVRNGDLQTLCENVPRLLTGLAGNPDYAPGFAVQSDAVVVAMWLWRTLCESDTPNKLR
FT                   ATPTRGSC"
FT   CDS             complement(55839..57248)
FT                   /transl_table=11
FT                   /locus_tag="Rv1586c"
FT                   /product="Probable phiRv1 integrase"
FT                   /function="integration of phiRv1 into chromosome."
FT                   /note="Rv1586c, (MTCY336.18), len: 469 aa. Probable phiRv1
FT                   integrase, possibly member of the serine family of
FT                   recombinases (see citation below), similar to several
FT                   bacteriophage integrases e.g. Q37839 ORF469 PROTEIN from
FT                   Bacteriophage R4 (469 aa), FASTA scores: opt: 623, E():
FT                   1.6e-29, (31.1% identity in 482 aa overlap); and
FT                   Bacteriophage TP901-1."
FT                   /db_xref="GOA:O06604"
FT                   /db_xref="InterPro:IPR006119"
FT                   /db_xref="UniProtKB/TrEMBL:O06604"
FT                   /protein_id="CAB09083.1"
FT                   /translation="MRYTTPVRAAVYLRISEDRSGEQLGVARQREDCLKLCGQRKWVPV
FT                   EYLDNDVSASTGKRRPAYEQMLADITAGKIAAVVAWDLDRLHRRPIELEAFMSLADEKR
FT                   LALATVAGDVDLATPQGRLVARLKGSVAAHETEHKKARQRRAARQKAERGHPNWSKAFG
FT                   YLPGPNGPEPDPRTAPLVKQAYADILAGASLGDVCRQWNDAGAFTITGRPWTTTTLSKF
FT                   LRKPRNAGLRAYKGARYGPVDRDAIVGKAQWSPLVDEATFWAAQAVLDAPGRAPGRKSV
FT                   RRHLLTGLAGCGKCGNHLAGSYRTDGQVVYVCKACHGVAILADNIEPILYHIVAERLAM
FT                   PDAVDLLRREIHDAAEAETIRLELETLYGELDRLAVERAEGLLTARQVKISTDIVNAKI
FT                   TKLQARQQDQERLRVFDGIPLGTPQVAGMIAELSPDRFRAVLDVLAEVVVQPVGKSGRI
FT                   FNPERVQVNWR"
FT   CDS             complement(56905..57906)
FT                   /transl_table=11
FT                   /locus_tag="Rv1587c"
FT                   /product="Partial REP13E12 repeat protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1587c, (MTCY336.17), len: 333 aa. Partial REP13E12
FT                   repeat protein (see citation below), nearly identical (but
FT                   has been interrupted by phiRv1 prophage) to
FT                   Q50655|MTCY251.13c|Rv0094c HYPOTHETICAL 34.6 kDa PROTEIN
FT                   from M. tuberculosis (317 aa), FASTA results: opt: 1511,
FT                   E(): 1.1e-84, (97.75% identity in 224 aa overlap). Codon
FT                   usage suggests that translation may involve frameshifting
FT                   of Rv1588c mRNA in poly_C stretch into reading frame of
FT                   Rv1587c. 3' end found in Rv1572c. Lenght extended since
FT                   first submission (+115 aa)."
FT                   /db_xref="InterPro:IPR003615"
FT                   /db_xref="UniProtKB/TrEMBL:O06603"
FT                   /protein_id="CAB09082.2"
FT                   /translation="MLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGLL
FT                   AGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGKGFTGGGTLLPMADVIRMTSHAH
FT                   HYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFANDRGCTKPGCDAPAYHSQAH
FT                   HVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGHTEWLPPPHLDHGQPWTCEI
FT                   HYTCACCCLPPNLRRPLRRTARRGPPTRGLPKAVRAAKMGARRVPRQRRQRINRQAPPR
FT                   LRADVGRHHRRQDRRRGGLGPGPAPSPSHRAGSLHVISRREAAGPGHRRRRR"
FT   repeat_region   complement(57257..57268)
FT                   /note="12 bp direct repeat 2, ccacggccaacc, flanking
FT                   phage-like element, first site at 1779266..1779277"
FT   repeat_region   complement(57257..58554)
FT                   /label=REP-5
FT                   /rpt_type=DIRECT
FT                   /note="REP-5, len: 1298 bp. REP336, member of REP13E12
FT                   family."
FT   CDS             complement(57911..58579)
FT                   /transl_table=11
FT                   /locus_tag="Rv1588c"
FT                   /product="Partial REP13E12 repeat protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1588c, (MTCY336.16), len: 222 aa. Partial REP13E12
FT                   repeat protein (see citation below), nearly identical to
FT                   ORF's in other Rep13E12 repeats, including
FT                   Rv0095c|MTCY251.14c|Y05E_MYCTU|Q10891 hypothetical 15.4 kd
FT                   protein cy251.14 from Mycobacterium tuberculosis (136 aa),
FT                   FASTA results: opt: 613, E(): 9.9e-29, (86.5% identity in
FT                   111 aa overlap)."
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5F1"
FT                   /protein_id="CAB09081.1"
FT                   /translation="MLANSREELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLEC
FT                   LVRRLPAVGHALINQLDAQASEEELGGTLCCALANRLRITKPDAARRIADAADLGPRRA
FT                   LTGEPLAPQLTATATAQRQGLIGEAHVKVIRALFRPPARRGGCVHPPGRRSRPGRQSRS
FT                   ISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL
FT                   "
FT   CDS             59027..60076
FT                   /transl_table=11
FT                   /gene="bioB"
FT                   /locus_tag="Rv1589"
FT                   /product="PROBABLE BIOTIN SYNTHETASE BIOB"
FT                   /function="INVOLVED IN BIOTIN SYNTHESIS."
FT                   /EC_number="2.8.1.-"
FT                   /note="Rv1589, (MTCY336.15c), len: 349 aa. Probable bioB,
FT                   biotin synthetase (EC 2.8.1.-) O06601. Highly similar to
FT                   BIOB_MYCLE|P46715 BioB from Mycobacterium leprae (345 aa),
FT                   FASTA results: opt: 1982, E(): 0, (86.5% identity in 349 aa
FT                   overlap). Identical to AF041819|AF041819_9 bioB from
FT                   Mycobacterium bovis BCG (349 aa). TBparse score is 0.875."
FT                   /db_xref="GOA:P0A506"
FT                   /db_xref="InterPro:IPR007197"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A506"
FT                   /protein_id="CAB09080.1"
FT                   /translation="MTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLAV
FT                   LQLPDDRLEELLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSGLFASPVRS
FT                   AWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLMAQVAAGIEAIRNEVEINIACSL
FT                   GMLTAEQVDQLAARGVHRYNHNLETARSFFANVVTTHTWEERWQTLSMVRDAGMEVCCG
FT                   GILGMGETLQQRAEFAAELAELGPDEVPLNFLNPRPGTPFADLEVMPVGDALKAVAAFR
FT                   LALPRTMLRFAGGREITLGDLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLDELQM
FT                   PLKALNASL"
FT   CDS             60077..60316
FT                   /transl_table=11
FT                   /locus_tag="Rv1590"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1590, (MTCY336.14c), len: 79 aa. Conserved
FT                   hypothetical protein, similar to
FT                   Q49616|LEPB1170_C1_162|YF90_MYCLE from Mycobacterium leprae
FT                   (80 aa), FASTA scores: opt: 368, E(): 1.7e-21,
FT                   Smith-Waterman score: 368, (67.1% identity in 73 aa
FT                   overlap). TBparse score is 0.909"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64881"
FT                   /protein_id="CAB09079.1"
FT                   /translation="MVEIVAGKQRAPVAAGVYNVYTGELADTATPTAARMGLEPPRFCA
FT                   QCGRRMVVQVRPDGWWARCSRHGQVDSADLATQR"
FT   CDS             60313..60978
FT                   /transl_table=11
FT                   /locus_tag="Rv1591"
FT                   /product="PROBABLE TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1591, (MTCY336.13c), len: 221 aa. Probable
FT                   transmembrane protein, similar to
FT                   Q49626|LEPB1170_C3_229|YF91_MYCLE Hypothetical
FT                   Mycobacterium leprae protein (198 aa), FASTA results: opt:
FT                   802, E(): 0, (63.8% identity in 188 aa overlap). TBparse
FT                   score is 0.912."
FT                   /db_xref="GOA:P0A5F3"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5F3"
FT                   /protein_id="CAB09078.1"
FT                   /translation="MTEPPGFGGPSEPSGAPRTSRTRAVLFVMLGLSATGVLVGGLWAW
FT                   IAPPIHAVVAITRAGERVHEYLGSESQNFFIAPFMLLGLLSVLAVVASALMWQWREHRG
FT                   PQMVAGLSIGLTTAAAIAAGVGALVVRLRYGALDFDTVPLSRGDHALTYVTQAPPVFFA
FT                   RRPLQIALTLMWPAGIASLVYALLAAGTARDDLGGYPAVDPSSNARTEALETPQAPVS"
FT   CDS             complement(61143..62483)
FT                   /transl_table=11
FT                   /locus_tag="Rv1592c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1592c, (MTCY336.12), len: 446 aa. Conserved
FT                   hypothetical protein, some similarity to Q49629|B1170_F1_46
FT                   from Mycobacterium leprae (132 aa), FASTA results: opt:
FT                   332, E(): 4.5e-14, (56.3% identity in 87 aa overlap).
FT                   Nearly identical to truncated Mycobacterium bovis BCG
FT                   protein (148 aa) AF041819|AF041819_11. TBparse score is
FT                   0.918."
FT                   /db_xref="GOA:O06598"
FT                   /db_xref="InterPro:IPR005152"
FT                   /db_xref="UniProtKB/TrEMBL:O06598"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09077.1"
FT                   /translation="MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDDPFYFPPAGY
FT                   QHAVPGTVLRSRDVELAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIVPAELAPGQ
FT                   TCPLLSYQCAIDAMSSRCFPSYALRRRAKALGSLTQMELLMISAALAEGWAVSVPDHEG
FT                   PKGLWGSPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASAWAAEACGEYA
FT                   PDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAALQHSYPGLARVIKEHANDEG
FT                   RQLLEQLTEMTTVDAVIRMAGRDMGDFLDEPLEDILSTPEISHVFGDTKLGSAVPTPPV
FT                   LIVQAVHDYLIDVSDIDALADSYTAGGANVTYHRDLFSEHVSLHPLSAPMTLRWLTDRF
FT                   AGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL"
FT   CDS             complement(62740..63450)
FT                   /transl_table=11
FT                   /locus_tag="Rv1593c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1593c, (MTCY336.11), len: 236 aa. Conserved
FT                   hypothetical protein, highly similar to Q49628|B1170_F1_44
FT                   from Mycobacterium leprae (286 aa), FASTA scores: opt:
FT                   1304, E (): 0, (85.4% identity in 233 aa overlap); similar
FT                   to several putative DNA hydrolases e.g. Q9S233|SCI51.07C
FT                   from Streptomyces coelicolor (239 aa), FASTA scores: opt:
FT                   415, E(): 4.6e-20, (34.8% identity in 221 aa overlap); also
FT                   similar to P74291|SLR1690 hypothetical protein from
FT                   synechocystis (261 aa), FASTA scores: opt: 228, E():
FT                   1.4e-17, (31.5% identity in 213 aa overlap). TBparse score
FT                   is 0.922"
FT                   /db_xref="GOA:O06597"
FT                   /db_xref="InterPro:IPR000086"
FT                   /db_xref="UniProtKB/TrEMBL:O06597"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09076.1"
FT                   /translation="MAHGSTAHEVLAVVFQVRGVGMSRGAAKPQLNVLLWQRAKEPQRG
FT                   AWSLPGGRLRNDEDMTSSVRRQLAEKVDLRELAHLEQLAVFSDPHRLPGIRMIASTYLG
FT                   VVPSPATPELPADTRWHPVSSLPPMAFDHGPMVTHARTRLIAKMSYTNIGFALAPKEFA
FT                   LSTLRDIYGAALGYQVDATNLQRVLARRRVITQTGTIAQSGRSGGRPAALYRFTDSQLR
FT                   VTDEFAALRPPGQL"
FT   CDS             63499..64548
FT                   /transl_table=11
FT                   /gene="nadA"
FT                   /locus_tag="Rv1594"
FT                   /product="Probable quinolinate synthetase nadA"
FT                   /function="quinolinate biosynthesis"
FT                   /note="Rv1594, (MTCY336.10c), len: 349 aa. Probable nadA,
FT                   quinolinate synthetase. Similar to many e.g. Q49622 NADA
FT                   from Mycobacterium leprae (368 aa), FASTA results: opt:
FT                   1994, E(): 0, (84.4% identity in 352 aa overlap)."
FT                   /db_xref="GOA:P65497"
FT                   /db_xref="InterPro:IPR003473"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65497"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09075.1"
FT                   /translation="MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLR
FT                   GATVLAHNYQLPAIQDVADHVGDSLALSRVAAEAPEDTIVFCGVHFMAETAKILSPHKT
FT                   VLIPDQRAGCSLADSITPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNAVDV
FT                   VASIDPDREVLFCPDQFLGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDA
FT                   ELFVHPECGCATSALYLAGEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQ
FT                   LRRAAPEVDFRAVNDRASCKYMKMITPAALLRCLVEGADEVHVDPGIAASGRRSVQRMI
FT                   EIGHPGGGE"
FT   CDS             64548..66131
FT                   /transl_table=11
FT                   /gene="nadB"
FT                   /locus_tag="Rv1595"
FT                   /product="Probable L-aspartate oxidase nadB"
FT                   /function="QUINOLINATE BIOSYNTHESIS. CATALYZES THE
FT                   OXIDATION OF L-ASPARTATE TO IMINOASPARTATE WHICH IS
FT                   CONDENSED WITH DIHYDROXYACETONE PHOSPHATE TO QUINOLINATE
FT                   UNDER THE ACTION OF QUINOLINATE SYNTHASE A [CATALYTIC
FT                   ACTIVITY : L-ASPARTATE + H(2)O + O(2) = OXALOACETATE +
FT                   NH(3) + H(2)O(2)]"
FT                   /EC_number="1.4.3.16"
FT                   /note="Rv1595, (MTCY336.09c), len: 527 aa. Probable nadB,
FT                   L-aspartate oxidase (EC 1.4.3.16). Similar to many e.g.
FT                   Q49617 L-ASPARTATE OXIDASE (QUINOLINATE SYNTHETASE) from
FT                   Mycobacterium leprae (424 aa), FASTA results: opt: 2152,
FT                   E(): 0, (82.0% identity in 400 aa overlap). Also shows some
FT                   similarity to Rv1552 frdA from Mycobacterium tuberculosis
FT                   (583 aa), FASTA results: E(): 1e-10, (35.3% identity in 566
FT                   aa overlap). HETERODIMER. THE QUINOLINATE SYNTHETASE
FT                   COMPLEX CONSISTS OF THE TWO ENZYMES QUINOLINATE SYNTHETASE
FT                   A AND B. TBparse score is 0.896."
FT                   /db_xref="GOA:P65499"
FT                   /db_xref="HSSP:1CHU"
FT                   /db_xref="InterPro:IPR005288"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65499"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09074.1"
FT                   /translation="MAGPAWRDAADVVVIGTGVAGLAAALAADRAGRSVVVLSKAAQTH
FT                   VTATHYAQGGIAVVLPDNDDSVDAHVADTLAAGAGLCDPDAVYSIVADGYRAVTDLVGA
FT                   GARLDESVPGRWALTREGGHSRRRIVHAGGDATGAEVQRALQDAAGMLDIRTGHVALRV
FT                   LHDGTAVTGLLVVRPDGCGIISAPSVILATGGLGHLYSATTNPAGSTGDGIALGLWAGV
FT                   AVSDLEFIQFHPTMLFAGRAGGRRPLITEAIRGEGAILVDRQGNSITAGVHPMGDLAPR
FT                   DVVAAAIDARLKATGDPCVYLDARGIEGFASRFPTVTASCRAAGIDPVRQPIPVVPGAH
FT                   YSCGGIVTDVYGQTELLGLYAAGEVARTGLHGANRLASNSLLEGLVVGGRAGKAAAAHA
FT                   AAAGRSRATSSATWPEPISYTALDRGDLQRAMSRDASMYRAAAGLHRLCDSLSGAQVRD
FT                   VACRRDFEDVALTLVAQSVTAAALARTESRGCHHRAEYPCTVPEQARSIVVRGADDANA
FT                   VCVQALVAVC"
FT   CDS             66131..66988
FT                   /transl_table=11
FT                   /gene="nadC"
FT                   /locus_tag="Rv1596"
FT                   /product="Probable nicotinate-nucleotide pyrophosphatase
FT                   nadC"
FT                   /function="DE NOVO BIOSYNTHESIS OF NAD AND NADP [CATALYTIC
FT                   ACTIVITY : NICOTINATE D-RIBONUCLEOTIDE + DIPHOSPHATE +
FT                   CO(2) = PYRIDINE-2,3-DICARBOXYLATE +
FT                   5-PHOSPHO-ALPHA-D-RIBOSE 1-DIPHOSPHATE]"
FT                   /EC_number="2.4.2.19"
FT                   /note="Rv1596, (MTCY336.08c), len: 285 aa. Probable nadC,
FT                   nicotinate-nucleotide pyrophosphatase (EC 2.4.2.19) O06594.
FT                   Similar to many e.g. ADC_MYCLE|P46714 from Mycobacterium
FT                   leprae (284 aa), FASTA results: opt: 1418, E(): 0,(79.2%
FT                   identity in 283 aa overlap). BELONGS TO THE NADC/MODD
FT                   FAMILY. TBparse score is 0.902."
FT                   /db_xref="GOA:O06594"
FT                   /db_xref="InterPro:IPR002638"
FT                   /db_xref="PDB:1QPN"
FT                   /db_xref="UniProtKB/Swiss-Prot:O06594"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09073.1"
FT                   /translation="MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASL
FT                   VTREAGVVAGLDVALLTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLTAE
FT                   RTMLNLVGHLSGIATATAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVNHRL
FT                   GLGDAALIKDNHVAAAGSVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPELILLD
FT                   NFAVWQTQTAVQRRDSRAPTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDI
FT                   GLDM"
FT   CDS             67037..67795
FT                   /transl_table=11
FT                   /locus_tag="Rv1597"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1597, (MTCY336.07c), len: 252 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="GOA:O06593"
FT                   /db_xref="InterPro:IPR013216"
FT                   /db_xref="UniProtKB/TrEMBL:O06593"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09097.1"
FT                   /translation="MARTFEDLVAEAASASVGGWGFSWLDGRATEERPSWGYQRQLSQR
FT                   LANATAALDLETGGGEVLAGAGNFPPTMVATEAWPPNAAMATRRLHPLGAVVVITGDKP
FT                   PLPFADAAFDLVTSRHPSTRWWTEIARVLRAGGSYFAQHVGPATLWDLREHFLGPREHN
FT                   GADQYAQVVRTCITDAGLEIVDLQMERLRVEFFDVGAVIYFLRKVIWFLPDFTVEGYHD
FT                   RLRALHERIQAEGPFVTYSTRALIEARKPS"
FT   CDS             complement(67816..68226)
FT                   /transl_table=11
FT                   /locus_tag="Rv1598c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1598c, (MTCY336.06), len: 136 aa. Conserved
FT                   hypothetical protein, some similarity to
FT                   O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis
FT                   (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99
FT                   aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa)."
FT                   /db_xref="InterPro:IPR004378"
FT                   /db_xref="UniProtKB/TrEMBL:O06592"
FT                   /protein_id="CAB09096.1"
FT                   /translation="MSAKDHPNNAPGVPMVFPLWLERLQVKYINRALKPIARYLPGTAT
FT                   IEHRGRKSGKPYQTIVTAYRKDGVLAIALAHGKTDWVKNVLAAGEADVHFARGVVHVIN
FT                   PRIVPAGSDGQGLPRMARLQLRRIGVFVGDIA"
FT   CDS             68326..69642
FT                   /transl_table=11
FT                   /gene="hisD"
FT                   /locus_tag="Rv1599"
FT                   /product="Probable histidinol dehydrogenase HisD (HDH)"
FT                   /function="Involved in histidine biosynthesis pathway
FT                   (tenth step). THIS PROTEIN IS CONSIDERED AS A BIFUNCTIONAL
FT                   ENZYME, POSSESSING TWO ACTIVE SITES, ONE AN ALCOHOL
FT                   DEHYDROGENASE AND THE OTHER AN ALDEHYDE DEHYDROGENASE
FT                   [CATALYTIC ACTIVITY : L-HISTIDINOL + 2 NAD(+) + H(2)O =
FT                   L-HISTIDINE + 2 NADH]."
FT                   /EC_number="1.1.1.23"
FT                   /note="Rv1599, (MTCY336.05c), len: 438 aa. Probable hisD,
FT                   histidinol dehydrogenase (EC 1.1.1.23) (see citation below)
FT                   O08396. Similar to many e.g. HISX_MYCSM|P28736 from
FT                   Mycobacterium smegmatis (445 aa), FASTA results: opt: 2356,
FT                   E(): 0, (83.1% identity in 437 aa overlap). Contains
FT                   histidinol dehydrogenase signature (PS00611)."
FT                   /db_xref="GOA:P63950"
FT                   /db_xref="HSSP:1K75"
FT                   /db_xref="InterPro:IPR012131"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63950"
FT                   /protein_id="CAB09095.1"
FT                   /translation="MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAER
FT                   GAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVMVERTRAVHSGQRRT
FT                   DVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQ
FT                   AQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNI
FT                   YVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPS
FT                   EDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQ
FT                   TADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGI
FT                   HVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER"
FT   misc_feature    69034..69132
FT                   /note="PS00611 Histidinol dehydrogenase signature"
FT   CDS             69639..70781
FT                   /transl_table=11
FT                   /gene="hisC1"
FT                   /locus_tag="Rv1600"
FT                   /standard_name="hisC"
FT                   /product="Probable histidinol-phosphate aminotransferase
FT                   hisC1"
FT                   /function="histidine biosynthesis (eighth step) [CATALYTIC
FT                   ACTIVITY : L-HISTIDINOL-PHOSPHATE + 2-OXOGLUTARATE =
FT                   3-(IMIDAZOL-4-YL)-2-OXOPROPYL PHOSPHATE + L-GLUTAMATE]"
FT                   /EC_number="2.6.1.9"
FT                   /note="Rv1600, (MTCY336.04c), len: 380 aa. Probable hisC1,
FT                   histidinol-phosphate aminotransferase (EC 2.6.1.9) O06591.
FT                   Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces
FT                   coelicolor (369 aa), FASTA results: opt: 1353, E(): 0,
FT                   (59.0% identity in 356 aa overlap). Some similarity to
FT                   other Mycobacterium tuberculosis aminotransferases e.g.
FT                   Rv3772|MTCY13D12.06, FASTA results: E(): 7.4e-25, (33.7%
FT                   identity in 365 aa overlap). Contains aminotransferases
FT                   class-II pyridoxal-phosphate attachment site (PS00599).
FT                   BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT
FT                   AMINOTRANSFERASES. Note that previously known as hisC."
FT                   /db_xref="GOA:P0A678"
FT                   /db_xref="HSSP:1FG7"
FT                   /db_xref="InterPro:IPR015421"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A678"
FT                   /protein_id="CAE55407.1"
FT                   /translation="MTRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPP
FT                   TRALVDDVVRSVREAAIDLHRYPDRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNE
FT                   ILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAAVVD
FT                   RKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPS
FT                   KLVVTRTMSKAFAFAGGRLGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDT
FT                   LSSVAALIAERERVTTSLNDMGFRVIPSDANFVLFGEFADAPAAWRRYLEAGILIRDVG
FT                   IPGYLRATTGLAEENDAFLRASARIATDLVPVTRSPVGAP"
FT   misc_feature    70323..70352
FT                   /note="PS00599 Aminotransferases class-II
FT                   pyridoxal-phosphate attachment site"
FT   CDS             70778..71410
FT                   /transl_table=11
FT                   /gene="hisB"
FT                   /locus_tag="Rv1601"
FT                   /product="Probable imidazole glycerol-phosphate dehydratase
FT                   hisB"
FT                   /function="histidine biosynthesis (seventh step) [CATALYTIC
FT                   ACTIVITY : D-ERYTHRO-1-(IMIDAZOL-4-YL)GLYCEROL 3- PHOSPHATE
FT                   = 3-(IMIDAZOL-4-YL)-2-OXOPROPYL PHOSPHATE + H(2)O]"
FT                   /EC_number="4.2.1.19"
FT                   /note="Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,
FT                   imidazole glycerol-phosphate dehydratase (EC 4.2.1.19).
FT                   Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces
FT                   coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4%
FT                   identity in 202 aa overlap). BELONGS TO THE
FT                   IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE FAMILY. TBparse
FT                   score is 0.910."
FT                   /db_xref="GOA:P64368"
FT                   /db_xref="InterPro:IPR000807"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64368"
FT                   /protein_id="CAB09093.1"
FT                   /translation="MTTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFY
FT                   DHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAF
FT                   IPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARI
FT                   ALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL"
FT   CDS             71407..72027
FT                   /transl_table=11
FT                   /gene="hisH"
FT                   /locus_tag="Rv1602"
FT                   /product="Probable amidotransferase hisH"
FT                   /function="histidine biosynthesis pathway (fifth step).
FT                   CATALYZES AN AMIDOTRANSFERASE REACTION THAT GENERATES
FT                   IMIDAZOLE-GLYCEROL PHOSPHATE AND
FT                   5-AMINOIMIDAZOL-4-CARBOXAMIDE RIBONUCLEOTIDE, WHICH IS USED
FT                   FOR PURINE SYNTHESIS."
FT                   /EC_number="2.4.2.-"
FT                   /note="Rv1602, (MTCY336.02c), len: 206 aa. Probable hisH,
FT                   amidotransferase (EC 2.4.2.-). Similar to many e.g.
FT                   HIS5_STRCO|P16249 from Streptomyces coelicolor (222 aa),
FT                   FASTA results: opt: 872, E():0, (61.0% identity in 210 aa
FT                   overlap). Contains glutamine amidotransferases class-I
FT                   active site (PS00442). BELONGS TO THE HISH FAMILY. TBparse
FT                   score is 0.931."
FT                   /db_xref="GOA:O06589"
FT                   /db_xref="HSSP:1JVN"
FT                   /db_xref="InterPro:IPR016226"
FT                   /db_xref="UniProtKB/Swiss-Prot:O06589"
FT                   /protein_id="CAB09092.1"
FT                   /translation="MTAKSVVVLDYGSGNLRSAQRALQRVGAEVEVTADTDAAMTADGL
FT                   VVPGVGAFAACMAGLRKISGERIIAERVAAGRPVLGVCVGMQILFACGVEFGVQTPGCG
FT                   HWPGAVIRLEAPVIPHMGWNVVDSAAGSALFKGLDVDARFYFVHSYAAQRWEGSPDALL
FT                   TWATYRAPFLAAVEDGALAATQFHPEKSGDAGAAVLSSWVDGL"
FT   misc_feature    71638..71673
FT                   /note="PS00442 Glutamine amidotransferases class-I active
FT                   site"
FT   CDS             72037..72774
FT                   /transl_table=11
FT                   /gene="hisA"
FT                   /locus_tag="Rv1603"
FT                   /product="PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE
FT                   CARBOXAMIDE RIBOTIDE ISOMERASE HISA"
FT                   /function="histidine biosynthesis pathway (fourth step)
FT                   [CATALYTIC ACTIVITY :
FT                   N-(5'-PHOSPHO-D-RIBOSYLFORMIMINO)-5-AMINO-1-(5''-PHOSPHOR
FT                   IB OSYL)-4-IMIDAZOLECARBOXAMIDE =
FT                   N-(5'-PHOSPHO-D-1'-RIBULOSYLFORMIMINO)-5-AMINO-1-(5''-PHO
FT                   SP HORIBOSYL)-4- IMIDAZOLECARBOXAMIDE.]"
FT                   /EC_number="5.3.1.16"
FT                   /note="Rv1603, (MTV046.01-MTCY336.01c), len: 245 aa.
FT                   Probable hisA, PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE
FT                   CARBOXAMIDE RIBOTIDE ISOMERASE (EC 5.3.1.16), similar to
FT                   many e.g. HIS4_STRCO|P16250
FT                   phosphoribosylformimino-5-aminoimidaz from Streptomyces
FT                   coelicolor (240 aa), FASTA scores: opt: 1081, E(): 0,
FT                   (69.0% identity in 239 aa overlap)."
FT                   /db_xref="GOA:P60578"
FT                   /db_xref="InterPro:IPR010188"
FT                   /db_xref="UniProtKB/Swiss-Prot:P60578"
FT                   /protein_id="CAB09091.1"
FT                   /translation="MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDG
FT                   AEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVG
FT                   TAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEG
FT                   CSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEG
FT                   AIVGKALYARRFTLPQALAAVRD"
FT   CDS             72782..73594
FT                   /transl_table=11
FT                   /gene="impA"
FT                   /locus_tag="Rv1604"
FT                   /product="PROBABLE INOSITOL-MONOPHOSPHATASE IMPA (IMP)"
FT                   /function="INVOLVED IN INOSITOL PHOSPHATE METABOLISM. IT IS
FT                   RESPONSIBLE FOR THE PROVISION OF INOSITOL REQUIRED FOR
FT                   SYNTHESIS OF PHOSPHATIDYLINOSITOL AND
FT                   POLYPHOSPHOINOSITIDES. KEY ENZYME OF THE PHOSPHATIDYL
FT                   INOSITOL SIGNALING PATHWAY [CATALYTIC ACTIVITY: INOSITOL
FT                   1(or 4)-MONOPHOSPHATE + H(2)O = INOSITOL +
FT                   ORTHOPHOSPHATE]."
FT                   /EC_number="3.1.3.25"
FT                   /note="Rv1604, (MTV046.02), len: 270 aa. Probable impA,
FT                   inositol monophosphatase (EC 3.1.3.25), similar to many
FT                   e.g. AF0059|AF005905_2 inositol monophosphate phosphatase
FT                   from Mycobacterium smegmatis (276 aa), FASTA scores: opt:
FT                   1241, E(): 0, (70.5% identity in 261 aa overlap). Also
FT                   similar to Mycobacterium tuberculosis proteins Rv3137 and
FT                   Rv2701c."
FT                   /db_xref="GOA:O53907"
FT                   /db_xref="InterPro:IPR017955"
FT                   /db_xref="UniProtKB/TrEMBL:O53907"
FT                   /protein_id="CAA17593.1"
FT                   /translation="MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATE
FT                   VDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINYAAGSPLAAILL
FT                   GLLHDGVPVAGLTWMPFTDPRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFSADS
FT                   RGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVA
FT                   LVRAAGGVVTDLAGQPWTPASRSALAGPPRVHAQILEILGSIGEPEDY"
FT   CDS             73596..74399
FT                   /transl_table=11
FT                   /gene="hisF"
FT                   /locus_tag="Rv1605"
FT                   /product="Probable cyclase hisF"
FT                   /function="histidine biosynthesis pathway (sixth step).
FT                   CATALYZES THE CYCLIZATION REACTION THAT PRODUCES
FT                   D-ERYTHRO-IMIDAZOLE GLYCEROL PHOSPHATE."
FT                   /note="Rv1605, (MTV046.03), len: 267 aa. Probable hisF,
FT                   cyclase involved in histidine biosynthetic pathway, similar
FT                   to many e.g. AF0304|AF030405_1 Corynebacterium glutamicum
FT                   cyclase (257 aa), FASTA scores: opt: 1201, E(): 0, (71.9%
FT                   identity in 256 aa overlap). BELONGS TO THE HISA / HISF
FT                   FAMILY. TBparse score is 0.890."
FT                   /db_xref="GOA:O53908"
FT                   /db_xref="HSSP:1GPW"
FT                   /db_xref="InterPro:IPR004651"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53908"
FT                   /protein_id="CAA17594.1"
FT                   /translation="MYADRDLPGAGGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVE
FT                   LAAVYDAEGADELTFLDVTASSSGRATMLEVVRRTAEQVFIPLTVGGGVRTVADVDSLL
FT                   RAGADKVAVNTAAIACPDLLADMARQFGSQCIVLSVDARTVPVGSAPTPSGWEVTTHGG
FT                   RRGTGMDAVQWAARGADLGVGEILLNSMDADGTKAGFDLALLRAVRAAVTVPVIASGGA
FT                   GAVEHFAPAVAAGADAVLAASVFHFRELTIGQVKAALAAEGITVR"
FT   CDS             74396..74743
FT                   /transl_table=11
FT                   /gene="hisI"
FT                   /locus_tag="Rv1606"
FT                   /product="Probable phosphoribosyl-AMP 1,6 cyclohydrolase
FT                   hisI"
FT                   /function="Involved in histidine biosynthesis pathway (at
FT                   the third step) [CATALYTIC ACTIVITY : 5-PHOSPHORIBOSYL-AMP
FT                   + H(2)O =
FT                   5-(5-PHOSPHO-D-RIBOSYLAMINOFORMIMINO)-1-(5-PHOSPHO-RIBOSY
FT                   L) IMIDAZOLE-4- CARBOXAMIDE.]"
FT                   /EC_number="3.5.4.19"
FT                   /note="Rv1606, (MTV046.04), len: 115 aa. Probable hisI,
FT                   phosphoribosyl-AMP 1,6 cyclohydrolase (EC 3.5.4.19),
FT                   similar to several e.g. X82010|RSHISI_2 HISI from
FT                   Rhodobacter sphaeroides (119 aa), FASTA scores: opt: 378,
FT                   E(): 2.8e-21, (52.3% identity in 109 aa overlap); etc.
FT                   TBparse score is 0.916."
FT                   /db_xref="GOA:P0A5B3"
FT                   /db_xref="InterPro:IPR002496"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5B3"
FT                   /protein_id="CAB10717.2"
FT                   /translation="MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALART
FT                   LQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSC
FT                   FDAAVLLEPDD"
FT   CDS             74924..76006
FT                   /transl_table=11
FT                   /gene="chaA"
FT                   /locus_tag="Rv1607"
FT                   /product="Probable ionic transporter integral membrane
FT                   protein chaA"
FT                   /function="INVOLVED IN TRANSPORT OF IONS (PRESUMABLY
FT                   CALCIUM) ACROSS THE MEMBRANE. RESPONSIBLE FOR THE
FT                   TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE."
FT                   /note="Rv1607, (MTV046.05), len: 360 aa. Probable chaA,
FT                   ionic transporter integral membrane protein, putative
FT                   calcium/proton antiporter, similar to many e.g.
FT                   P31801|CHAA_ECOLI CALCIUM/PROTON ANTIPORTER from
FT                   Escherichia coli (366 aa), FASTA scores: opt: 736, E(): 0,
FT                   (35.9% identity in 351 aa overlap). Equivalent to
FT                   Mycobacterium leprae AL049913|MLCB1610_21 (77.7% identity
FT                   in 364 aa overlap). SEEMS TO BELONG TO THE CaCA FAMILY.
FT                   TBparse score is 0.888."
FT                   /db_xref="GOA:O53910"
FT                   /db_xref="InterPro:IPR004837"
FT                   /db_xref="UniProtKB/TrEMBL:O53910"
FT                   /protein_id="CAA17596.1"
FT                   /translation="MLKRVPWTVVLPSLAFVALVLTWGKQIGPVVGLLAAVLLAGAVLA
FT                   AVNHAEVVAARVGEPFGSLVLAVAVTTIEVALIVALMVSGGDDAATLARDTVFAAVMIT
FT                   TNGIAGLSLLLGSLRYGVTLFNPHGSGAALATVTTLATLSLVLPTFTTSQSGPELSPGQ
FT                   LIFAGAASLGLYVLFLFTQTVRHRDFFLPVAQKGAVEDDSHADPPSTRAALLSLGLLLV
FT                   ALVAVVGLAKVESPVIEEVVSAAGFPQSFVGVVIATLVLLPETLAAARAARQGRLQTSL
FT                   NLAYGSAMASIGLTIPTIALASLWLSGPLQLGLGAIQLVLLVLTVVVSVLTVVPGRATR
FT                   LQGEVHLVLLAAYLFLAVVP"
FT   CDS             complement(76041..76505)
FT                   /transl_table=11
FT                   /gene="bcpB"
FT                   /locus_tag="Rv1608c"
FT                   /product="Probable peroxidoxin BcpB"
FT                   /function="peroxide detoxification"
FT                   /note="Rv1608c, (MTV046.06), len: 154 aa. Probable bcpB,
FT                   peroxidoxin or bacterioferritin comigratory protein,
FT                   similar to many, e.g. AE0003|ECAE000335_4 bacterioferritin
FT                   comigratory protein from Escherichia coli K-12 MG1655 (156
FT                   aa), FASTA scores: opt: 329, E(): 1.2e-16, (38.2% identity
FT                   in 152 aa overlap); Z97179|MLCL383_22 Mycobacterium leprae
FT                   cosmid L383 (161 aa) (40.2% identity in 132 aa overlap).
FT                   Also similar to Rv2428 AhpC, alkyl hydroperoxide reductase
FT                   from Mycobacterium tuberculosis; and other Mycobacterium
FT                   tuberculosis putative peroxidoxins Rv2521, Rv2238c,
FT                   Rv1932."
FT                   /db_xref="GOA:O53911"
FT                   /db_xref="InterPro:IPR017936"
FT                   /db_xref="UniProtKB/TrEMBL:O53911"
FT                   /protein_id="CAA17597.1"
FT                   /translation="MKTGDTVADFELPDQTGTPRRLSVLLSDGPVVLFFYPAAMTPGCT
FT                   KEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVRRFDYPLLSDAQGTVAAQFGVK
FT                   RGLLGKLMPVKRTTFVIDTDRKVLDVISSEFSMDAHADKALATLRAIRSG"
FT   CDS             76646..78196
FT                   /transl_table=11
FT                   /gene="trpE"
FT                   /locus_tag="Rv1609"
FT                   /product="Probable anthranilate synthase component I trpE
FT                   (GLUTAMINE AMIDOTRANSFERASE)"
FT                   /function="Involved in tryptophan biosynthesis pathway (at
FT                   the first step). SUPPOSED TETRAMER OF TWO COMPONENTS I AND
FT                   TWO COMPONENTS II: COMPONENT I (Rv1609|trpE) CATALYZES THE
FT                   FORMATION OF ANTHRANILATE USING AMMONIA RATHER THAN
FT                   GLUTAMINE, WHEREAS COMPONENT II (Rv0013|trpG) PROVIDES
FT                   GLUTAMINE AMIDOTRANSFERASE ACTIVITY [CATALYTIC ACTIVITY:
FT                   CHORISMATE + L-GLUTAMINE = ANTHRANILATE + PYRUVATE +
FT                   L-GLUTAMATE]."
FT                   /EC_number="4.1.3.27"
FT                   /note="Rv1609, (MTCY01B2.01, MTV046.07), len: 516 aa.
FT                   Probable trpE, anthranilate synthase component I (EC
FT                   4.1.3.27). FASTA best: TRPE_CLOTM|P14953 anthranilate
FT                   synthase component I from Clostridium thermocellum (494
FT                   aa), E(): 0, (42.6% identity in 498 aa overlap). Some
FT                   similarity to Rv2386c|MTCY253.35, E(): 6.3e-17; and
FT                   Rv3215|MTCY07D11.11c, E(): 5.7e-15. BELONGS TO THE
FT                   ANTHRANILATE SYNTHASE COMPONENT I FAMILY."
FT                   /db_xref="GOA:P67001"
FT                   /db_xref="HSSP:1K0E"
FT                   /db_xref="InterPro:IPR015890"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67001"
FT                   /protein_id="CAB08903.1"
FT                   /translation="MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLA
FT                   ANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLRAL
FT                   QVTLELLATADRQSEPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLAT
FT                   DVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSR
FT                   PEPRHRAQRTVEEYGAIVEYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNP
FT                   SPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEK
FT                   ELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGE
FT                   GRTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAI
FT                   RTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC"
FT   CDS             78186..78893
FT                   /transl_table=11
FT                   /locus_tag="Rv1610"
FT                   /product="POSSIBLE CONSERVED MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1610, (MTCY01B2.02), len: 235 aa. Possible
FT                   conserved membrane protein. Equivalent to
FT                   AL049913|MLCB1610_23 hypothetical protein from
FT                   Mycobacterium leprae (264 aa), FASTA score: (65.8% identity
FT                   in 231 aa overlap)."
FT                   /db_xref="InterPro:IPR019051"
FT                   /db_xref="UniProtKB/TrEMBL:O06128"
FT                   /protein_id="CAB08904.1"
FT                   /translation="MAANAGSVRPNRRARPMIGIAQLLLVVAAGALWMAARLPWVVIGS
FT                   FDELGPPKEVTLTGASWSTALLPLALLMLAAAVAALAVRGWPLRALAVLLAAASFAVGY
FT                   LGISLWVVPDVAARGADLAHVPVVTLVGSARHYWGAVAAVLAAVCALLAAVFLMSSAAI
FT                   RGSAGEDMARYAAPRARRSIARRQHSNAAGRAAPQDDGPDMGPRMSERMIWEALDEGRD
FT                   PTDREQESDTEGR"
FT   CDS             78983..79801
FT                   /transl_table=11
FT                   /gene="trpC"
FT                   /locus_tag="Rv1611"
FT                   /product="Probable indole-3-glycerol phosphate synthase
FT                   trpC"
FT                   /function="tryptophan biosynthesis pathway (fourth step)
FT                   [CATALYTIC ACTIVITY :
FT                   1-(2-CARBOXYPHENYLAMINO)-1-DEOXY-D-RIBULOSE 5-PHOSPHATE =
FT                   1-(INDOL-3-YL)GLYCEROL 3-PHOSPHATE + CO(2) + H(2)O.]"
FT                   /EC_number="4.1.1.48"
FT                   /note="Rv1611, (MTCY01B2.03), len: 272 aa. Probable trpC,
FT                   indole-3-glycerol phosphate synthase (EC 4.1.1.48). Similar
FT                   to Q55508|SLR0546 HYPOTHETICAL 33.0 kDa PROTEIN from
FT                   SYNECHOCYSTIS SP (295 aa), FASTA score: opt: 26, E():
FT                   7.6e-32, (44.2% identity in 265 aa overlap); also similar
FT                   to TRPC_AZOBR|P26938 ndole-3-glycerol-phosphate
FT                   synthaseindole-3-glycerol-phosphate synthase from
FT                   Azospirillum brasilense (262 aa), FASTA score: opt: 596,
FT                   E(): 4.8e-30, (43.8% identity in 258 aa overlap).
FT                   Equivalent to AL0499 13|MLCB1610_24 from Mycobacterium
FT                   leprae (272 aa) (90.8% identity in 272 aa overlap).
FT                   Contains indole-3-glycerol phosphate synthase signature
FT                   (PS00614). BELONGS TO THE TRPC FAMILY."
FT                   /db_xref="GOA:P0A632"
FT                   /db_xref="HSSP:1PII"
FT                   /db_xref="InterPro:IPR001468"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A632"
FT                   /protein_id="CAB08905.1"
FT                   /translation="MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMA
FT                   ALREPGIGVIAEVKRASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDD
FT                   LDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGM
FT                   TALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGV
FT                   RGTADLLAYAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR"
FT   misc_feature    79142..79186
FT                   /note="PS00614 Indole-3-glycerol phosphate synthase
FT                   signature"
FT   CDS             79870..81102
FT                   /transl_table=11
FT                   /gene="trpB"
FT                   /locus_tag="Rv1612"
FT                   /product="Probable tryptophan synthase, beta subunit trpB"
FT                   /function="tryptophan biosynthesis pathway (fifth last
FT                   step). THE BETA SUBUNIT IS RESPONSIBLE FOR THE SYNTHESIS OF
FT                   L-TRYPTOPHAN FROM INDOLE AND L-SERINE. [CATALYTIC ACTIVITY
FT                   : L-SERINE + 1-(INDOL-3-YL)GLYCEROL 3-PHOSPHATE =
FT                   L-TRYPTOPHAN + GLYCERALDEHYDE 3-PHOSPHATE + H(2)O]"
FT                   /EC_number="4.2.1.20"
FT                   /note="Rv1612, (MTCY01B2.04), len: 410 aa. Probable trpB,
FT                   tryptophan synthase beta chain (EC 4.2.1.20). Equivalent to
FT                   AL049913|MLCB1610_25 from Mycobacterium leprae (340 aa)
FT                   (88.5% identity in 331 aa overlap). Similar to others e.g.
FT                   TRPB_CAUCR|P12290 tryptophan synthase beta chain from
FT                   Caulobacter crescentus (406 aa), FASTA scores: opt: 1662,
FT                   E(): 0, (60.6% identity in 404 aa overlap). BELONGS TO THE
FT                   TRPB FAMILY. TETRAMER OF TWO ALPHA AND TWO BETA CHAINS."
FT                   /db_xref="GOA:P66984"
FT                   /db_xref="InterPro:IPR006654"
FT                   /db_xref="PDB:2O2E"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66984"
FT                   /protein_id="CAB08906.1"
FT                   /translation="MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAY
FT                   QKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKINN
FT                   VLGQALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTARQALNVARM
FT                   RLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRII
FT                   GMEARVQIQGQAGRLPDAVVACVGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRH
FT                   AATFTAGSPGAFHGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKEAGRVDYRP
FT                   ITDSEAMDAFGLLCRMEGIIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVET
FT                   AAKWFGLLGND"
FT   misc_feature    80149..80178
FT                   /note="PS00168 Tryptophan synthase beta chain
FT                   pyridoxal-phosphate attachment site"
FT   CDS             81102..81914
FT                   /transl_table=11
FT                   /gene="trpA"
FT                   /locus_tag="Rv1613"
FT                   /product="Probable tryptophan synthase, alpha subunit trpA"
FT                   /function="tryptophan biosynthesis pathway (fifth - last
FT                   step). THE ALPHA SUBUNIT IS RESPONSIBLE FOR THE ALDOL
FT                   CLEAVAGE OF INDOLEGLYCEROL PHOSPHATE TO INDOLE AND
FT                   GLYCERALDEHYDE 3- PHOSPHATE. [CATALYTIC ACTIVITY: L-SERINE
FT                   + 1-(INDOL-3-YL)GLYCEROL 3-PHOSPHATE = L-TRYPTOPHAN +
FT                   GLYCERALDEHYDE 3-PHOSPHATE + H(2)O.]"
FT                   /EC_number="4.2.1.20"
FT                   /note="Rv1613, (MTCY01B2.05), len: 270 aa. Probable trpA,
FT                   tryptophan synthase alpha chain (EC 4.2.1.20). FASTA best:
FT                   O68906|TRPA_MYCIT TRYPTOPHAN SYNTHASE ALPHA CHAIN from
FT                   Mycobacterium intracellulare (271 aa), opt: 1442, E(): 0,
FT                   (85.3% identity in 265 aa overlap)."
FT                   /db_xref="GOA:P66980"
FT                   /db_xref="HSSP:1GEQ"
FT                   /db_xref="InterPro:IPR002028"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66980"
FT                   /protein_id="CAB08890.1"
FT                   /translation="MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAM
FT                   TALVESGCDIIEVGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAGGRAV
FT                   VMTYWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASEEHRLDRIFLVAPS
FT                   STPERLAATVEASRGFVYAASTMGVTGARDAVSQAAPELVGRVKAVSDIPVGVGLGVRS
FT                   RAQAAQIAQYADGVIVGSALVTALTEGLPRLRALTGELAAGVRLGMSA"
FT   CDS             81914..83320
FT                   /transl_table=11
FT                   /gene="lgt"
FT                   /locus_tag="Rv1614"
FT                   /product="Possible prolipoprotein diacylglyceryl
FT                   transferases Lgt"
FT                   /function="prolipoprotein modification"
FT                   /EC_number="2.4.99.-"
FT                   /note="Rv1614, (MTCY01B2.06), len: 468 aa. Possible lgt,
FT                   prolipoprotein diacylglyceryl transferases (EC 2.4.99.-),
FT                   similar to many prolipoprotein diacylglyceryl transferases.
FT                   FASTA scores: LGT_STAAU|P52282 prolipoprotein
FT                   diacylglyceryl transferase from Staphylococcus aureus
FT                   subsp. (279 aa), opt: 289, E():3.6e- 09, (31.5% identity in
FT                   257 aa overlap); AL096884|SC4G6_3 cosmid 4G6 from
FT                   Streptomyces coelicolor (343 aa), opt: 735, E(): 4e-32,
FT                   (46.5% identity in 391 aa overlap)."
FT                   /db_xref="GOA:O06131"
FT                   /db_xref="InterPro:IPR001640"
FT                   /db_xref="UniProtKB/Swiss-Prot:O06131"
FT                   /protein_id="CAB08891.1"
FT                   /translation="MRMLPSYIPSPPRGVWYLGPLPVRAYAVCVITGIIVALLIGDRRL
FT                   TARGGERGMTYDIALWAVPFGLIGGRLYHLATDWRTYFGDGGAGLAAALRIWDGGLGIW
FT                   GAVTLGVMGAWIGCRRCGIPLPVLLDAVAPGVVLAQAIGRLGNYFNQELYGRETTMPWG
FT                   LEIFYRRDPSGFDVPNSLDGVSTGQVAFVVQPTFLYELIWNVLVFVALIYIDRRFIIGH
FT                   GRLFGFYVAFYCAGRFCVELLRDDPATLIAGIRINSFTSTFVFIGAVVYIILAPKGREA
FT                   PGALRGSEYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEV
FT                   TDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPE
FT                   EPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDDPAEPDGIRRQDDFSSRRR
FT                   RWWRLRRRRQ"
FT   CDS             83996..84436
FT                   /transl_table=11
FT                   /locus_tag="Rv1615"
FT                   /product="Probable hypothetical membrane protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1615, (MTCY01B2.07), len: 146 aa. Probable
FT                   membrane protein"
FT                   /db_xref="InterPro:IPR007829"
FT                   /db_xref="UniProtKB/TrEMBL:O06132"
FT                   /protein_id="CAB08892.1"
FT                   /translation="MGLRPARVVRPARSGMLKGVTDPLQHGAFEPGWQSAPPGYPPPYP
FT                   QYPGPGSYFDPFAPYGRHPVTGQPFSDKSKTVAGLLQLLGLFGIAGIGRIYLGHTGLGI
FT                   AQLLVGWVTCGLGAVIWGVIDALLILTDKVGDPWGRPLRDGS"
FT   CDS             84426..84824
FT                   /transl_table=11
FT                   /locus_tag="Rv1616"
FT                   /product="CONSERVED MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1616, (MTCY01B2.08), len: 132 aa. Conserved
FT                   membrane protein, with some similarity to other
FT                   hypothetical proteins e.g. AL096884|SC4G6_9 from
FT                   Streptomyces coelicolor cosmid 4G6 (148 aa), FASTA scores:
FT                   opt: 245, E(): 1.7e-1 0, (36.7% identity in 128 aa
FT                   overlap); Q55401|SLL0543 HYPOTHETICAL 16.5 kDa PROTEIN from
FT                   SYNECHOCYSTIS SP (148 aa), FASTA scores: opt: 225, E():
FT                   6.5e-10, (35.9% identity in 117 aa overlap). Has cysteine
FT                   cluster and contains a rubredoxin signature (PS00202)."
FT                   /db_xref="InterPro:IPR018527"
FT                   /db_xref="UniProtKB/TrEMBL:O06133"
FT                   /protein_id="CAB08893.1"
FT                   /translation="MEASGRQRRYAAAGSVVLLAGALGYIGLVDPHNSNSLYPPCLFKL
FT                   LTGWNCPACGGLRMIHDLLHGELAASINDNVFLLVGVPVLASWVLLRRRHGDLALPIPV
FT                   MIAVAVAVIAWTVLRNLPGFPLVPTISG"
FT   misc_feature    84558..84590
FT                   /note="PS00202 Rubredoxin signature"
FT   CDS             84932..86350
FT                   /transl_table=11
FT                   /gene="pykA"
FT                   /locus_tag="Rv1617"
FT                   /product="Probable pyruvate kinase pykA"
FT                   /function="produces phosphoenol pyruvate in glycolysis
FT                   [CATALYTIC ACTIVITY : ATP + PYRUVATE = ADP +
FT                   PHOSPHOENOLPYRUVATE]"
FT                   /EC_number="2.7.1.40"
FT                   /note="Rv1617, (MTCY01B2.09), len: 472 aa. Probable pykA,
FT                   pyruvate kinase (EC 2.7.1.40). FASTA best: Q46078 PYRUVATE
FT                   KINASE from CORYNEBACTERIUM GLUTAMICUM (475 aa), opt: 2221,
FT                   E(): 0, (72.2% identity in 468 aa overlap). BELONGS TO THE
FT                   PYRUVATE KINASE FAMILY."
FT                   /db_xref="GOA:O06134"
FT                   /db_xref="HSSP:1E0T"
FT                   /db_xref="InterPro:IPR015793"
FT                   /db_xref="UniProtKB/Swiss-Prot:O06134"
FT                   /protein_id="CAB08894.1"
FT                   /translation="MTRRGKIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHK
FT                   VAYERVRVASDATGRAVGVLADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSHDR
FT                   VSTTYKRLAQDAVAGDRVLVDDGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLPGMN
FT                   VTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAKLEKP
FT                   EAIDNLEAIVLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDS
FT                   MIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAA
FT                   PPLTHIPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWP
FT                   EVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGS
FT                   TNLIHVHRIGEDDV"
FT   CDS             86358..87260
FT                   /transl_table=11
FT                   /gene="tesB1"
FT                   /locus_tag="Rv1618"
FT                   /product="Probable acyl-CoA thioesterase II tesB1"
FT                   /function="Involved in fatty acid metabolism."
FT                   /EC_number="3.1.2.-"
FT                   /note="Rv1618, (MTCY01B2.10), len: 300 aa. Probable tesB1,
FT                   acyl-CoA thioesterase II (EC 3.1.2.-), similar to other
FT                   acyl-CoA thioesterases e.g. TESB_ECOLI|P23911 acyl-coa
FT                   thioesterase II from Escherichia coli (285 aa), FASTA
FT                   scores: opt: 495, E(): 2.9e-27, (32.5% identity in 283 aa
FT                   overlap); etc. Also similar to Rv2605c|tesB2 from M.
FT                   tuberculosis."
FT                   /db_xref="GOA:O06135"
FT                   /db_xref="HSSP:1C8U"
FT                   /db_xref="InterPro:IPR003703"
FT                   /db_xref="UniProtKB/TrEMBL:O06135"
FT                   /protein_id="CAB08895.1"
FT                   /translation="MPDGKPMSDFDELLAVLDLNAVASDLFTGSHPSKNPLRTFGGQLM
FT                   AQSFVASSRTLTRHHLPPSAFSVHFINGGDTAKDIEFQVIRLRDERRFANRRVDAVQDG
FT                   TLLSSAMVSYMAGGRGHEHALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWR
FT                   YANDPAWIMRDKGDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLS
FT                   WGFDRIFAASANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGKLIATVV
FT                   QEGVLKYFPATPDSAAGRS"
FT   CDS             87318..88772
FT                   /transl_table=11
FT                   /locus_tag="Rv1619"
FT                   /product="CONSERVED MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1619, (MTCY01B2.11), len: 484 aa. Conserved
FT                   membrane protein. Some similarity to N-terminus of
FT                   P94974|Rv1640c|MTCY06H11.04c PROBABLE LYSYL-TRNA SYNTHETASE
FT                   2 (EC 6.1.1.6) from Mycobacterium tuberculosis (1172 aa),
FT                   FASTA scores: E(): 1.4e-16, (28.0% identity in 410 aa
FT                   overlap); and similar in part to O69916| SC3C8.03C Putative
FT                   intergral membrane protein from Streptomyces coelicolor
FT                   cosmid 3C8 (589 aa), FASTA scores: opt: 453 E(): 8.4e-22,
FT                   (31.3% identity in 313 aa overlap)."
FT                   /db_xref="InterPro:IPR007426"
FT                   /db_xref="UniProtKB/TrEMBL:O06136"
FT                   /protein_id="CAB08896.1"
FT                   /translation="MVAAAGEPLNCQRANPEVTVKLPSADVVPRLRGRQRVVVHVDSRT
FT                   ARCVGALALVCAACWLIALLAGDYRHAQWAVAGRLGWSLTVLAAVAFIARGIFLGRPVT
FT                   AMHATAAGLFLLAGLAAHVLVADLLGEILIAGSGWALMWPTSAHPRPEDLPRVWALINA
FT                   TRADSLAPFAMQAGKSHHFSAAGTAALAYRTRIGYAVVSGDPIGDEAQFPQLVADFAAM
FT                   CHMHGWRIVVVGCSERRLGLWSDPMVVGQSLRPIPIGRDVVIDVSNFEMTGRRFRNLRQ
FT                   AVKRTHNFGVTTEIVAEQQLDDQRQAELAEVLAASPSGARTDRGFCMNLDGVLEGRYPG
FT                   IQLIIARDASGRVQGFHRYATAGGGSDMSLDVPWRRRGAPNGIDERLSADMIAAAKDAG
FT                   VQRLSLAFAAFPDLFGANQLGRLQRVCRALIHILDPLIALESLYRYLRKFHALDERRYV
FT                   LISMTQVFALALVLLSLEFVPRRRHL"
FT   CDS             complement(88706..90436)
FT                   /transl_table=11
FT                   /gene="cydC"
FT                   /locus_tag="Rv1620c"
FT                   /product="PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF
FT                   CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC
FT                   TRANSPORTER CYDC"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT ACROSS THE MEMBRANE
FT                   OF COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME:
FT                   INVOLVED IN CYTOCHROME BIOGENESIS (aerobic respiration).
FT                   RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM AND
FT                   FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE
FT                   MEMBRANE."
FT                   /note="Rv1620c, (MTCY01B2.12c), len: 576 aa. Probable cydC,
FT                   transmembrane ATP-binding protein ABC transporter involved
FT                   in transport of component linked with the assembly of
FT                   cytochrome (see citation below), similar to others e.g.
FT                   CYDC_ECOLI|P23886 transport ATP-binding protein from
FT                   Escherichia coli (573 aa), FASTA scores: opt: 631, E():
FT                   1.6e-30, (28.5% identity in 569 aa overlap); C-terminal
FT                   part of AL034355|SCD78_14 from Streptomyces coelicolor
FT                   (1172 aa), FASTA scores: opt: 956, E(): 0, (38.8% identity
FT                   in 554 aa overlap); etc. Contains (PS00211) ABC
FT                   transporters family signature, and (PS00017)
FT                   ATP/GTP-binding site motif A (P-loop). BELONGS TO THE
FT                   ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)."
FT                   /db_xref="GOA:O06137"
FT                   /db_xref="InterPro:IPR017940"
FT                   /db_xref="UniProtKB/TrEMBL:O06137"
FT                   /protein_id="CAB08897.1"
FT                   /translation="MNRPSAVSRRQRDLLAASGLLGPRLPRILAAVALGVLSLGSALAL
FT                   AGVSAWLITRAWQMPPVLDLSVAVVAVRAFAISRGVLHYCERLATHDTALRAAGRARTL
FT                   IYHRLAHGPAAAAVGLHSGDLAARVGADVDELANMLVRALVPIAVAAVLAVAATAVVAA
FT                   VSVPAAVVLAVCLLVAGVVAPWLAGRTAAAQEAIARQHRGMRDTSAMIALEHAPELRVA
FT                   GALRNVIADSQRRQHAWADALDAAARTGAIAEAMPTAAIGASLLGAVVAGIGMAPTVAP
FT                   TTLAILMLLPLSAFEATVALPAAAVQLTRSRIAAARLLDLTGSNRVRETESTVSARLPV
FT                   GTGVLAADVCCGHQEAQSIRVTIDLPPGARLAVTGASGAGKTTLLMTLAGLLPPVHGRV
FT                   LLDGTNLSDFDEDELRSAVSFFAEDAHIFATTVRDNLLTARGDCPDDELIEALDRVGLC
FT                   GWLAGLPEGLSTVLIGGAQAVSAGQRRRLLLARAVLSPARIVLLDEPVEHLDAANADLL
FT                   RDLLAPNSGIMSAMRTVVVATHHLPNDIQCAELSIATDQRCRRRGTNSSDNNTNASAKT
FT                   "
FT   misc_feature    complement(88958..89002)
FT                   /note="PS00211 ABC transporters family signature"
FT   misc_feature    complement(89291..89314)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(90433..92016)
FT                   /transl_table=11
FT                   /gene="cydD"
FT                   /locus_tag="Rv1621c"
FT                   /product="PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF
FT                   CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC
FT                   TRANSPORTER CYDD"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT ACROSS THE MEMBRANE
FT                   OF COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME:
FT                   INVOLVED IN CYTOCHROME BIOGENESIS (aerobic respiration).
FT                   RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM AND
FT                   FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE
FT                   MEMBRANE."
FT                   /note="Rv1621c, (MTCY01B2.13c), len: 527 aa. Probable cydD,
FT                   transmembrane ATP-binding protein ABC transporter involved
FT                   in transport of component linked with the assembly of
FT                   cytochrome (see citation below), similar to others e.g.
FT                   P94366|CYDC_BACSU TRANSPORT ATP-BINDING PROTEIN from
FT                   Bacillus subtilis (567 aa), FASTA scores: opt: 784, E(): 0,
FT                   (30.1% identity in 535 aa overlap); N-terminal part of
FT                   AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa),
FT                   FASTA scores: opt: 1295, E(): 0, (44.6% identity in 534 aa
FT                   overlap); etc. Also similar to Q11019|Y07D_MYCTU from
FT                   Mycobacterium tuberculosis (579 aa), FASTA scores: opt:
FT                   530, E(): 6.9e-25, (29.1% identity in 530 aa overlap).
FT                   Contains (PS00211) ABC transporters family signature, and
FT                   (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO
FT                   THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC
FT                   TRANSPORTERS)."
FT                   /db_xref="GOA:O06138"
FT                   /db_xref="HSSP:1R0W"
FT                   /db_xref="InterPro:IPR017940"
FT                   /db_xref="UniProtKB/TrEMBL:O06138"
FT                   /protein_id="CAB08898.1"
FT                   /translation="MACGVGISGCAIGSAIVLASIVAGVIDPANPGMAGLRRWLGPLSI
FT                   LLVLWGLRASIQWLQARLAQRGASAVIADLSGQVLTAVTARRPSQLAAQRDAAAVLITR
FT                   GLDGLRPYFTGYLPTLLLAAILTPATVAVIGLYDLKSMAIVVITLPLIPIFMVLIGLAT
FT                   TNPSAAALAAMTAVQARLLDLIAGIPTLRALGRASGPEQRIAELSADHRRSAMATLRIA
FT                   FLSALVLELLATLGVALVAVGIGLRLVFGEMSLTAGLTVLLLAPEVYWPLRRVGVQFHA
FT                   AADGRTAADKAFALLGESPSPTPGRRTVTARGGVIRLERLSVRGRDGRAPYDLTADIEP
FT                   GRVTVLTGRNGAGKSTTLQAIAGLTAPSSGRITVAGVDVTNLAPAAWWRQLSWLPQRPV
FT                   LVPGTVRHNLVLLGPVDDLERACAAAGFDAVLDELPRGLDTVLGRGGVGLSLGQRQRLG
FT                   LARALGSPAAVLLLDEPTAHLDARTEQHVLGAIVERARAGATVLVVAHRQQVAAAGDRV
FT                   VEVNSDGFRR"
FT   misc_feature    complement(90628..90672)
FT                   /note="PS00211 ABC transporters family signature"
FT   misc_feature    complement(90952..90975)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(92103..93143)
FT                   /transl_table=11
FT                   /gene="cydB"
FT                   /locus_tag="Rv1622c"
FT                   /product="Probable integral membrane cytochrome D ubiquinol
FT                   oxidase (subunit II) cydB (Cytochrome BD-I oxidase subunit
FT                   II)"
FT                   /function="INVOLVED IN THE RESPIRATORY CHAIN (AT THE
FT                   TERMINAL STEP): AEROBIC RESPIRATION. CYTOCHROME D TERMINAL
FT                   OXIDASE COMPLEX IS THE COMPONENT OF THE AEROBIC RESPIRATORY
FT                   CHAIN THAT IS SUPPOSED PREDOMINATED WHEN CELLS ARE GROWN AT
FT                   LOW AERATION [CATALYTIC ACTIVITY: UBIQUINOL-8 + O(2) =
FT                   UBIQUINONE-8 + H(2)O]."
FT                   /EC_number="1.10.3.-"
FT                   /note="Rv1622c, (MTCY01B2.14c), len: 346 aa. Probable cydB,
FT                   cytochrome D ubiquinol oxidase subunit II (EC 1.10.3.-),
FT                   integral membrane protein, similar to others e.g.
FT                   P11027|CYDB_ECOLI CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II
FT                   from Escherichia coli strain K12 (379 aa), FASTA scores:
FT                   opt: 519, E(): 0, (32.3% identity in 372 aa overlap);
FT                   P94365|CYDB_BACSU CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II
FT                   from Bacillus subtilis (338 aa), FASTA scores: opt: 824,
FT                   E(): 0, (39.5% identity in 337 aa overlap); etc."
FT                   /db_xref="GOA:O06139"
FT                   /db_xref="InterPro:IPR003317"
FT                   /db_xref="UniProtKB/TrEMBL:O06139"
FT                   /protein_id="CAB08899.1"
FT                   /translation="MVLQELWFGVIAALFLGFFILEGFDFGVGMLMAPFAHVGMGDPET
FT                   HRRTALNTIGPVWDGNEVWLITAGAAIFAAFPGWYATVFSALYLPLLAILFGMILRAVA
FT                   IEWRGKIDDPKWRTGADFGIAAGSWLPALLWGVAFAILVRGLPVDANGHVALSIPDVLN
FT                   AYTLLGGLATAGLFSLYGAVFIALKTSGPIRDDAYRFAVWLSLPVAGLVAGFGLWTQLA
FT                   YGKDWTWLVLAVAGCAQAAATVLVWRRVSDGWAFMCTLIVVAAVVVLLFGALYPNLVPS
FT                   TLNPQWSLTIHNASSTPYTLKIMTWVTAFFAPLTVAYQTWTYWVFRQRISAERIPPPTG
FT                   LARRAP"
FT   CDS             complement(93173..94630)
FT                   /transl_table=11
FT                   /gene="cydA"
FT                   /locus_tag="Rv1623c"
FT                   /standard_name="appC"
FT                   /product="Probable integral membrane cytochrome D ubiquinol
FT                   oxidase (subunit I) cydA (Cytochrome BD-I oxidase subunit
FT                   I)"
FT                   /function="INVOLVED IN THE RESPIRATORY CHAIN (AT THE
FT                   TERMINAL STEP): AEROBIC RESPIRATION. CYTOCHROME D TERMINAL
FT                   OXIDASE COMPLEX IS THE COMPONENT OF THE AEROBIC RESPIRATORY
FT                   CHAIN THAT IS SUPPOSED PREDOMINATED WHEN CELLS ARE GROWN AT
FT                   LOW AERATION [CATALYTIC ACTIVITY: UBIQUINOL-8 + O(2) =
FT                   UBIQUINONE-8 + H(2)O]."
FT                   /EC_number="1.10.3.-"
FT                   /note="Rv1623c, (MTCY01B2.15c), len: 485 aa. Probable cydA
FT                   (previously known as appC, but renamed cydA to conform with
FT                   Mycobacterium smegmatis nomenclature), cytochrome D
FT                   ubiquinol oxidase subunit I (EC 1.10.3.-), integral
FT                   membrane protein, similar to others e.g.
FT                   P26459|APPC_ECOLI|CYXA|CBDA|B0978 CYTOCHROME BD-II OXIDASE
FT                   SUBUNIT I from Escherichia coli strain K12 (514 aa), FASTA
FT                   scores: opt: 870, E(): 0, (35.9% identity in 485 aa
FT                   overlap); AL034355|SCD78_12 from Streptomyces coelicolor
FT                   (501 aa), FASTA scores: opt: 1099, E(): 0, (48.6% identity
FT                   in 510 aa overlap); etc."
FT                   /db_xref="GOA:Q7D892"
FT                   /db_xref="InterPro:IPR002585"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D892"
FT                   /protein_id="CAE55408.1"
FT                   /translation="MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVMQTLWVVTDNP
FT                   AWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLAMEGLAAFF
FT                   FESTFIGLWIFGWNRLPRLVHLACIWIVAIAVNVSAFFIIAANSFMQHPVGAHYNPTTG
FT                   RAELSSIVVLLTNNTAQAAFTHTVSGALLTAGTFVAAVSAWWLVRSSTTHADSDTQAMY
FT                   RPATILGCWVALAATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNFSVLTVGR
FT                   QNNCDSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQRFGPNDYRPNLFVTYWS
FT                   FRMMIGLMAIPVLFALIALWLTRGGQIPNQRWFSWLALLTMPAPFLANSAGWVFTEMGR
FT                   QPWVVVPNPTGDQLVRLTVKAGVSDHSATVVATSLLMFTLVYAVLAVIWCWLLKRYIVE
FT                   GPLEHDAEPAAHGAPRDDEVAPLSFAY"
FT   CDS             complement(94741..95328)
FT                   /transl_table=11
FT                   /locus_tag="Rv1624c"
FT                   /product="Probable conserved membrane protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1624c, (MTCY01B2.16c), len: 195 aa. Probable
FT                   membrane protein, first start taken. Some similarity to
FT                   Rv3155 nuoK, NADH dehydrogenase chain K from M.
FT                   tuberculosis. Also similar to AAK72093.1|AF196488
FT                   hypothetical protein from Mycobacterium smegmatis (205 aa).
FT                   Identities = 117/195 (60%)."
FT                   /db_xref="InterPro:IPR005325"
FT                   /db_xref="UniProtKB/TrEMBL:O06141"
FT                   /protein_id="CAB08901.1"
FT                   /translation="MCHTAPMEPSPVVSPLPRLLPHLWKSTLASGILSLILGVLVLAWP
FT                   GISILVAAMAFGVYLLITGVAQVAFAFSLHVSAGGRILLFISGAASLILAVLAFRHFGD
FT                   AVLLLAIWIGIGFIFRGVATTVSAISDPMLPGRGWSIFVGVISLIAGIVVMASPFESIW
FT                   ILALVVGIWLVVIGTCEIASSFAIRKASQTLG"
FT   CDS             complement(95357..96688)
FT                   /transl_table=11
FT                   /gene="cya"
FT                   /locus_tag="Rv1625c"
FT                   /product="MEMBRANE-ANCHORED ADENYLYL CYCLASE CYA (ATP
FT                   PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE)"
FT                   /function="INVOLVED IN cAMP SYNTHESIS [CATALYTIC ACTIVITY:
FT                   ATP = 3',5'-CYCLIC AMP + DIPHOSPHATE]."
FT                   /EC_number="4.6.1.1"
FT                   /note="Rv1625c, (MT1661, MTCY01B2.17c), len: 418 aa. cya,
FT                   membrane-anchored adenylyl cyclase (EC 4.6.1.1) (see
FT                   citations below). C-terminal half is similar to region in
FT                   numerous eukaryotic adenylate and guanylate cyclases.
FT                   N-terminal half hydrophobic. FASTA score: CYG2_RAT|P22717
FT                   guanylate cyclase soluble, beta-2 chain (682 aa), FASTA
FT                   scores: opt: 552, E(): 2.7e-26, (40.3% identity in 226 aa
FT                   overlap). Some similarity to Rv2435c|MTCY428.11 from
FT                   Mycobacterium tuberculosis (730 aa), E(): 7e-19. Start
FT                   changed since first submission (+25 aa). BELONGS TO
FT                   ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY."
FT                   /db_xref="GOA:P0A4Y0"
FT                   /db_xref="InterPro:IPR018297"
FT                   /db_xref="PDB:1YK9"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A4Y0"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08902.2"
FT                   /translation="MAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQ
FT                   RVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLT
FT                   FIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIAL
FT                   EFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEAL
FT                   LANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYS
FT                   AFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNP
FT                   VPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDD
FT                   FVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV"
FT   tRNA            complement(96758..96831)
FT                   /gene="tRNA-Leu(CAA)"
FT                   /product="transfer RNA-Leu(CAA)"
FT                   /anticodon=(pos:96795..96797,aa:Leu)
FT   CDS             96923..97540
FT                   /transl_table=11
FT                   /locus_tag="Rv1626"
FT                   /product="Probable two-component system transcriptional
FT                   regulator"
FT                   /function="Sensor part of a two component regulatory
FT                   system"
FT                   /note="Rv1626, (MTCY01B2.18), len: 205 aa. Probable
FT                   two-component response system transcriptional regulator,
FT                   similar to many e.g. CHEY_BACSU|P24072 chemotaxis protein
FT                   chey homolog (119 aa), FASTA scores: opt: 283, E():
FT                   1.6e-16, (43.0% identity in 114 aa overlap). Also similar
FT                   to AL109732|SC7H2_27 hypothetical protein from Streptomyces
FT                   coelicolor (218 aa), opt: 880, E(): 0, (69.4% identity in
FT                   196 aa overlap)."
FT                   /db_xref="GOA:O06143"
FT                   /db_xref="InterPro:IPR008327"
FT                   /db_xref="PDB:1S8N"
FT                   /db_xref="UniProtKB/TrEMBL:O06143"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08879.1"
FT                   /translation="MTGPTTDADAAVPRRVLIAEDEALIRMDLAEMLREEGYEIVGEAG
FT                   DGQEAVELAELHKPDLVIMDVKMPRRDGIDAASEIASKRIAPIVVLTAFSQRDLVERAR
FT                   DAGAMAYLVKPFSISDLIPAIELAVSRFREITALEGEVATLSERLETRKLVERAKGLLQ
FT                   TKHGMTEPDAFKWIQRAAMDRRTTMKRVAEVVLETLGTPKDT"
FT   CDS             complement(97608..98816)
FT                   /transl_table=11
FT                   /locus_tag="Rv1627c"
FT                   /product="Probable nonspecific lipid-transfer protein"
FT                   /function="Thought to be involved in lipid metabolism."
FT                   /note="Rv1627c, (MTCY01B2.19c), len: 402 aa. Probable
FT                   nonspecific lipid-transfer protein, similar to many lipid
FT                   carrier proteins e.g. Q51797 ACETYL CoA SYNTHASE from
FT                   Pyrococcus furiosus (388 aa), FASTA scores: opt: 400, E():
FT                   3.2e-18, (34.4% identity in 407 aa overlap); etc. Also some
FT                   similarity to Mycobacterium tuberculosis proteins Rv3523,
FT                   Rv3540c, Rv0244, Rv2790c, Rv1323, etc."
FT                   /db_xref="GOA:O06144"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="UniProtKB/TrEMBL:O06144"
FT                   /protein_id="CAB08880.1"
FT                   /translation="MRMSAPEPVYILGAGMHPWGKWGNDFTEYGVVAARAALRDAGVDW
FT                   RHVQLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSARAQILA
FT                   GFCDVALVIGADTTPKGFFAPVGGERKGDPDWQRFHLIGATNTVYFALLARRRMDLYGA
FT                   TVEDFAQVKVKNSRHGLDNPNARYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALI
FT                   VASKSFTEKHLGSVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQI
FT                   LDAAYAEAGIGPEDLSLAEVYDLSTALELDWYEHLGLCPKGEAEALLRSGATTLGGRVP
FT                   VNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVADAKVGVTANQGLFGHGSSVI
FT                   VAR"
FT   CDS             complement(98813..99304)
FT                   /transl_table=11
FT                   /locus_tag="Rv1628c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1628c, (MTCY01B2.20c), len: 163 aa. Conserved
FT                   hypothetical protein, some similarity to others e.g. Q51796
FT                   ACAC PROTEIN in Pyrococcus furiosus (136 aa), FASTA scores:
FT                   opt: 199, E(): 4.6e-06, (34.7% identity in 121 aa overlap)"
FT                   /db_xref="InterPro:IPR002878"
FT                   /db_xref="UniProtKB/TrEMBL:O06145"
FT                   /protein_id="CAB08881.1"
FT                   /translation="MPEVTREEPAIDGWFTTDKAGNPHLLGGKCPQCGTYVFPPRADNC
FT                   PNPACGSDTLESVGLSTRGKLWSYTENRYAPPPPYPAPDPFEPFAVAAVELADEGLIVL
FT                   GKVVDGTLAADLKVGMEMELTTMPLFADDDGVQRIVYAWRIPSRAGDDAERSDAEERRR
FT                   "
FT   repeat_region   complement(98817..98868)
FT                   /note="52 bp Mycobacterial Interspersed Repetitive Unit,
FT                   Class II"
FT   CDS             99408..102122
FT                   /transl_table=11
FT                   /gene="polA"
FT                   /locus_tag="Rv1629"
FT                   /product="PROBABLE DNA POLYMERASE I POLA"
FT                   /function="INVOLVED IN POST-INCISION EVENTS. IN ADDITION TO
FT                   DNA POLYMERASE ACTIVITY, THIS DNA POLYMERASE EXHIBITS 3' TO
FT                   5' AND 5' TO 3' EXONUCLEASE ACTIVITY [CATALYTIC ACTIVITY :
FT                   N DEOXYNUCLEOSIDE TRIPHOSPHATE = N DIPHOSPHATE +
FT                   {DNA}(N)]."
FT                   /EC_number="2.7.7.7"
FT                   /note="Rv1629, (MTCY01B2.21), len: 904 aa. Probable polA,
FT                   DNA polymerase I (EC 2.7.7.7) (see citations below). Has
FT                   DNA polymerase family A signature (PS00447) at C-terminal
FT                   end. FASTA best: DPO1_MYCTU|Q07700 DNA polymerase I from
FT                   Mycobacterium tuberculosis (904 aa). Some similarity to
FT                   Rv2090|MTCY49.30 (393 aa), E(): 2.2e-18, (38.7% identity in
FT                   292 aa overlap). BELONGS TO DNA POLYMERASE TYPE-A FAMILY."
FT                   /db_xref="GOA:P0A550"
FT                   /db_xref="HSSP:1BGX"
FT                   /db_xref="InterPro:IPR008918"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A550"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08882.1"
FT                   /translation="MVTTASAPSEDRAKPTLMLLDGNSLAFRAFYALPAENFKTRGGLT
FT                   TNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRLQRYPEYKANRSSTPDEFAGQIDI
FT                   TKEVLGALGITVLSEPGFEADDLIATLATQAENEGYRVLVVTGDRDALQLVSDDVTVLY
FT                   PRKGVSELTRFTPEAVVEKYGLTPRQYPDFAALRGDPSDNLPGIPGVGEKTAAKWIAEY
FT                   GSLRSLVDNVDAVRGKVGDALRANLASVVRNRELTDLVRDVPLAQTPDTLRLQPWDRDH
FT                   IHRLFDDLEFRVLRDRLFDTLAAAGGPEVDEGFDVRGGALAPGTVRQWLAEHAGDGRRA
FT                   GLTVVGTHLPHGGDATAMAVAAADGEGAYLDTATLTPDDDAALAAWLADPAKPKALHEA
FT                   KAAVHDLAGRGWTLEGVTSDTALAAYLVRPGQRSFTLDDLSLRYLRRELRAETPQQQQL
FT                   SLLDDDDTDAETIQTTILRARAVIDLADALDAELARIDSTALLGEMELPVQRVLAKMES
FT                   AGIAVDLPMLTELQSQFGDQIRDAAEAAYGVIGKQINLGSPKQLQVVLFDELGMPKTKR
FT                   TKTGYTTDADALQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLQAVAADGRIHTTFNQ
FT                   TIAATGRLSSTEPNLQNIPIRTDAGRRIRDAFVVGDGYAELMTADYSQIEMRIMAHLSG
FT                   DEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKAMSYGLAYGLSAYGLSQQLK
FT                   ISTEEANEQMDAYFARFGGVRDYLRAVVERARKDGYTSTVLGRRRYLPELDSSNRQVRE
FT                   AAERAALNAPIQGSAADIIKVAMIQVDKALNEAQLASRMLLQVHDELLFEIAPGERERV
FT                   EALVRDKMGGAYPLDVPLEVSVGYGRSWDAAAH"
FT   misc_feature    101592..101651
FT                   /note="PS00447 DNA polymerase family A signature"
FT   CDS             102285..103730
FT                   /transl_table=11
FT                   /gene="rpsA"
FT                   /locus_tag="Rv1630"
FT                   /product="PROBABLE RIBOSOMAL PROTEIN S1 RPSA"
FT                   /function="BINDS MRNA; THUS FACILITATING RECOGNITION OF THE
FT                   INITIATION POINT. IT IS NEEDED TO TRANSLATE MRNA WITH A
FT                   SHORT SHINE-DALGARNO (SD) PURINE-RICH SEQUENCE."
FT                   /note="Rv1630, (MTCY01B2.22), len: 481 aa. Probable rpsA,
FT                   ribosomal protein S1. FASTA best: RS1_MYCLE|P46836 30s
FT                   ribosomal protein S1 from Mycobacterium leprae (482 aa),
FT                   opt: 2655, E(): 0, (87.2% identity in 483 aa overlap)."
FT                   /db_xref="GOA:O06147"
FT                   /db_xref="HSSP:1SRO"
FT                   /db_xref="InterPro:IPR003029"
FT                   /db_xref="UniProtKB/Swiss-Prot:O06147"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08883.1"
FT                   /translation="MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIVK
FT                   VDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSK
FT                   KRAQYERAWGTIEALKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQP
FT                   YIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSSIVNF
FT                   GAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSLKATQE
FT                   DPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAV
FT                   GDDAMVKVIDIDLERRRISLSLKQANEDYTEEFDPAKYGMADSYDEQGNYIFPEGFDAE
FT                   TNEWLEGFEKQRAEWEARYAEAERRHKMHTAQMEKFAAAEAAGRGADDQSSASSAPSEK
FT                   TAGGSLASDAQLAALREKLAGSA"
FT   CDS             103756..104979
FT                   /transl_table=11
FT                   /gene="coaE"
FT                   /locus_tag="Rv1631"
FT                   /product="Probable dephospho-CoA kinase coaE
FT                   (dephosphocoenzyme A kinase)"
FT                   /function="CATALYZES THE PHOSPHORYLATION OF THE 3'-HYDROXYL
FT                   GROUP OF DEPHOSPHOCOENZYME A TO FORM COENZYME A [CATALYTIC
FT                   ACTIVITY: ATP + dephospho-CoA <=> ADP + CoA]."
FT                   /EC_number="2.7.1.24"
FT                   /note="Rv1631, (MTCY01B2.23), len: 407 aa. Probable coaE,
FT                   dephospho-CoA kinase (EC 2.7.1.24), similar to many e.g.
FT                   Q50178|ML1383|COAE_MYCLE DEPHOSPHO-CoA KINASE from
FT                   Mycobacterium leprae (410 aa), FASTA scores: E(): 0, (77.5%
FT                   identity in 409 aa overlap). Has ATP/GTP-binding site motif
FT                   A (P-loop, PS00017) at N-terminus. IN THE N-TERMINAL
FT                   SECTION; BELONGS TO THE COAE FAMILY. IN THE C-TERMINAL
FT                   SECTION; BELONGS TO THE UPF0157 (GRPB) FAMILY."
FT                   /db_xref="GOA:P63826"
FT                   /db_xref="HSSP:1N3B"
FT                   /db_xref="InterPro:IPR007344"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63826"
FT                   /protein_id="CAB08884.1"
FT                   /translation="MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEG
FT                   LASLVDAFGRDILLADGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIAAVSG
FT                   DAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQASDQ
FT                   QRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPD
FT                   QARRIVNRLKIACGHKALRVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPL
FT                   LAAGYPRLEHITQDTEKTDARSTVGRYDHTDSAALWHKRVHASADPGRPTNVHLRVHGW
FT                   PNQQFALLFVDWLAANPGAREDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEW
FT                   ADAVHWRP"
FT   misc_feature    103777..103800
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(105130..105573)
FT                   /transl_table=11
FT                   /locus_tag="Rv1632c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1632c, (MTCY01B2.24c), len: 147 aa. Hypothetical
FT                   unknown protein ."
FT                   /db_xref="InterPro:IPR014465"
FT                   /db_xref="UniProtKB/TrEMBL:O06149"
FT                   /protein_id="CAB08885.1"
FT                   /translation="MRAVDEYTVHPWGLYLARPTPGRAQFHYLESWLLPSLGLRATVFH
FT                   FNPSHKRDHDYYLDVGEYTPGPSVWRSEDHYLDIEVRTGGGAELADVDELLDAVRHGLL
FT                   TPTVAEQAVRHAVDAVEGLARNGYDLTRWLATKGMELTWRSGS"
FT   CDS             105818..107914
FT                   /transl_table=11
FT                   /gene="uvrB"
FT                   /locus_tag="Rv1633"
FT                   /product="PROBABLE EXCINUCLEASE ABC (SUBUNIT B-HELICASE)
FT                   UVRB"
FT                   /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC
FT                   EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE
FT                   EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS
FT                   PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). UVRB
FT                   STIMULATES THE ATPASE ACTIVITY OF UVRA IN THE PRESENCE OF
FT                   UV-IRRADIATED DOUBLE-STRANDED DNA. IT ALSO ENHANCES THE
FT                   ABILITY OF UVRA TO BIND TO UV-IRRADIATED DUPLEX DNA"
FT                   /note="Rv1633, (MTCY01B2.25), len: 698 aa. Probable uvrB,
FT                   excinuclease ABC, subunit B; helicase (see Mizrahi &
FT                   Andersen 1998; Sancar 1994); has ATP/GTP-binding site motif
FT                   A (P-loop; PS00017) near N-terminus (see citation below).
FT                   FASTA best: UVRB_MICLU|P10125 from Micrococcus luteus (709
FT                   aa), opt: 3268, E(): 0, (71.3% identity in 704 aa overlap).
FT                   Also similar to Mycobacterium tuberculosis Rv2973c (recG);
FT                   and Rv1020 (mfd). BELONGS TO THE UVRB FAMILY."
FT                   /db_xref="GOA:P67422"
FT                   /db_xref="HSSP:1D9X"
FT                   /db_xref="InterPro:IPR004807"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67422"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08886.1"
FT                   /translation="MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGT
FT                   GKSATTAWLIERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYI
FT                   AQTDTYIEKDSSINDDVERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRSVEL
FT                   KVGEEVPRDGLLRLLVDVQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEI
FT                   EALYYLHPLTGEVIRQVDSLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKL
FT                   LEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDE
FT                   SHVTVPQIGGMYEGDISRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGP
FT                   YELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKK
FT                   MAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVS
FT                   LVAILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADKITDSMREAIDETERRRAKQ
FT                   IAYNEANGIDPQPLRKKIADILDQVYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVS
FT                   AGVFEGRDTSAMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKRELRGMDA
FT                   AGLK"
FT   misc_feature    105938..105961
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             107911..109326
FT                   /transl_table=11
FT                   /locus_tag="Rv1634"
FT                   /product="Possible drug efflux membrane protein"
FT                   /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF DRUG
FT                   ACROSS THE MEMBRANE (EXPORT). DRUG RESISTANCE BY AN EXPORT
FT                   MECHANISM (CONFERES RESISTANCE TO TOXIC COMPOUNDS BY
FT                   REMOVING THEM FOR THE CELLS)."
FT                   /note="Rv1634, (MTCY01B2.26), len: 471 aa. Possible drug
FT                   efflux membrane protein of major facilitator superfamily
FT                   (MFS), similar to many antibiotic resistance (efflux)
FT                   proteins. FASTA best: Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE
FT                   (GRAE) from Streptomyces violaceoruber (557 aa), opt: 415,
FT                   E(): 1.7e-17, (26.7% identity in 446 aa overlap). Relatives
FT                   in Mycobacterium tuberculosis: MTCY369.27c, E(): 4.8e-12;
FT                   MTCY20B11.14c, E(): 2.9e-10."
FT                   /db_xref="InterPro:IPR011701"
FT                   /db_xref="UniProtKB/TrEMBL:O06151"
FT                   /protein_id="CAB08887.1"
FT                   /translation="MTETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPS
FT                   TIADIGGSRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSYLMGLAVFGLASLVCAAA
FT                   PSMQILVAGRTLQGIAGGLLAGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGPATG
FT                   GLFAQLGLWRWAFGVMTLLTALMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMG
FT                   AAALAISVAALPNYLVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKWIYL
FT                   TMSVQMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSARVIGH
FT                   VVAAAPLVMASGLALGAVTQRADAPVGIIALWALALLIIGTGIGIAWPHLTVRAMDSVA
FT                   DPAESSAAAAAINVVQLISGAFGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIA
FT                   SYQATHRDRRLPR"
FT   CDS             complement(109315..110985)
FT                   /transl_table=11
FT                   /locus_tag="Rv1635c"
FT                   /product="Probable conserved transmembrane protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1635c, (MTCY01B2.27c), len: 556 aa. Probable
FT                   conserved transmembrane protein, equivalent to
FT                   CAC31770.1|AL583921 Mycobacterium leprae membrane protein
FT                   (527 aa), Identities = 332/527 (62%)."
FT                   /db_xref="GOA:O06152"
FT                   /db_xref="UniProtKB/TrEMBL:O06152"
FT                   /protein_id="CAB08888.1"
FT                   /translation="MHASRPGAPPHAGLPSRRTAGDQDHRADPKVTRIMSASTLEQPAA
FT                   AHVDELVARMRGRLLDPLAIAVLAAVISGAWASRPSLWFDEGATISASASRTLPELWSL
FT                   LGHIDAVHGLYYLLMHGWFAIFPPTELWSRLPSCLAIGAAAAGVVVFAKQFSGRTTAVC
FT                   AGAVFAILPRVTWAGIEARSSALSVAAAVWLTVLLVAAVRCNTQRRWLLYALVLMLSIL
FT                   VSINLALLVPAYATMVPLLASGKSRKSPVIWWTVVTAAALGAMTPFILFAHGQVWQVGW
FT                   IAGLNRNIILDVIHRQYFDHSVPFAILAGLIVAAGIAAHLAGARGPGGDTHRLVLVSAA
FT                   WIVVPTAVVLIYSATVEPIYYPRYLILTAPAAAVILAVCVVTIARKPWLIAGVVFLLAA
FT                   AAFPNYFFTQRGPYAKEGWDYSQVADVISAHAKPGDCLLVDNTAGWRPGPIRALLATRP
FT                   AAFRSLIDVERGTYGPKVGTLWDGHVAVWLTTAKIDKCPTLWTIANRDKSLPDHQVGEM
FT                   LSPGTGFGRTPVYRFPSYLGFRIVERWQFHYSQVVKSTR"
FT   CDS             111194..111634
FT                   /transl_table=11
FT                   /gene="TB15.3"
FT                   /locus_tag="Rv1636"
FT                   /product="IRON-REGULATED CONSERVED HYPOTHETICAL PROTEIN
FT                   TB15.3"
FT                   /function="UNKNOWN"
FT                   /note="Rv1636, (MTCY01B2.28), len: 146 aa. TB15.3,
FT                   iron-regulated conserved hypothetical protein (see
FT                   citations below), similar to other hypothetical proteins
FT                   from diverse organisms e.g. Q57951|MJ0531|Y531_METJA from
FT                   Methanococcus jannaschii (170 aa), FASTA scores: opt: 188,
FT                   E(): 6e-06, (32.2% identity in 149 aa overlap); also
FT                   P42297|YXIE_BACSU hypothetical 15.9 kDa protein in
FT                   bglh-wapa intergenic region precursor from Bacillus
FT                   subtilis (148 aa), FASTA scores: opt: 162, E(): 0.00025,
FT                   (30.8% identity in 156 aa overlap). Part of family of
FT                   Mycobacterium tuberculosis hypothetical proteins (but lacks
FT                   C-terminal region) including Rv2005c, Rv2623, Rv2026c,
FT                   Rv1996, etc."
FT                   /db_xref="GOA:O06153"
FT                   /db_xref="InterPro:IPR006015"
FT                   /db_xref="PDB:1TQ8"
FT                   /db_xref="UniProtKB/TrEMBL:O06153"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08889.1"
FT                   /translation="MSAYKTVVVGTDGSDSSMRAVDRAAQIAGADAKLIIASAYLPQHE
FT                   DARAADILKDESYKVTGTAPIYEILHDAKERAHNAGAKNVEERPIVGAPVDALVNLADE
FT                   EKADLLVVGNVGLSTIAGRLLGSVPANVSRRAKVDVLIVHTT"
FT   CDS             complement(111641..112435)
FT                   /transl_table=11
FT                   /locus_tag="Rv1637c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1637c, (MTCY01B2.29c,MTCY06H11.01c), len: 264 aa.
FT                   Conserved hypothetical protein, some similarity to others
FT                   e.g. P05446|GLO2_RHOBL PROBABLE HYDROXYACYLGLUTATHIONE
FT                   HYDROLASE (EC 3.1.2.6) (255 aa), FASTA scores: opt: 252,
FT                   E(): 2e-09, (39.0% identity in 146 aa overlap). Also
FT                   similar to Q9Z505|AL035591|SCC54.20 putative hydrolase from
FT                   Streptomyces coelicolor (218 aa), FASTA scores: opt: 732,
FT                   E(): 0, (52.3% identity in 220 aa overlap). Also similar to
FT                   Mycobacterium tuberculosis hypothetical proteins and
FT                   putative glyoxylases e.g. Rv0634c, Rv3677c, Rv2581c,
FT                   Rv2260."
FT                   /db_xref="GOA:O06154"
FT                   /db_xref="InterPro:IPR001279"
FT                   /db_xref="UniProtKB/TrEMBL:O06154"
FT                   /protein_id="CAB08907.1"
FT                   /translation="MLCARTDNHQGTGNVVTSAHMTRANDDDAGAAGIGAVAHMTTVDD
FT                   NYTGHVERGKAARRFLPGATILKASVGPMDNNAYLVTCSATGETLLIDAANDAEVLIDL
FT                   VRRYAPKLALIVTSHQHFDHWQALQAVAAATGAPTAAHPIDADPLPVKPDRLLTHGDSV
FT                   RIGELTFDVIHLRGHTPGSIALALGGPVTGGVTQLFTGDCLFPGGVGKTWQPADFTQLL
FT                   DDVTTRVFDVYADSTVIYPGHGDDTELGAERPSLSEWRARGW"
FT   CDS             112484..115402
FT                   /transl_table=11
FT                   /gene="uvrA"
FT                   /locus_tag="Rv1638"
FT                   /product="PROBABLE EXCINUCLEASE ABC (SUBUNIT A-DNA-BINDING
FT                   ATPase) UVRA"
FT                   /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC
FT                   EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE
FT                   EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS
FT                   PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). UVRA IS AN
FT                   ATPASE AND A DNA-BINDING PROTEIN THAT PREFERENTIALLY BINDS
FT                   SINGLE-STRANDED OR UV-IRRADIATED DOUBLE-STRANDED DNA."
FT                   /note="Rv1638, (MTCY06H11.01,MTCY06H11.02c), len: 972 aa.
FT                   Probable uvrA, excinuclease ABC, subunit A; DNA-binding
FT                   ATPase (see citations below), similar to many e.g.
FT                   UVRA_ECOLI|P07671 excinuclease abc subunit a from
FT                   Escherichia coli (940 aa), FASTA scores: opt: 2573, E(): 0,
FT                   (56.2% identity in 951 aa overlap). Contains 2x PS00017
FT                   ATP/GTP-binding site motif A, PS00211 ABC transporters
FT                   family signature, PS00211 ABC transporters family
FT                   signature. CONSISTS OF THREE SUBUNITS; UVRA, UVRB AND UVRC.
FT                   BELONGS TO THE ABC TRANSPORTER FAMILY. UVRA SUBFAMILY."
FT                   /db_xref="GOA:P63380"
FT                   /db_xref="InterPro:IPR004602"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63380"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06633.1"
FT                   /translation="MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDT
FT                   IFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITE
FT                   VYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQVLAMPEGTRFLVLAPVVRTRKGEF
FT                   ADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHDIEVVVDRLTVKAAAKRRLTDSV
FT                   ETALNLADGIVVLEFVDHELGAPHREQRFSEKLACPNGHALAVDDLEPRSFSFNSPYGA
FT                   CPECSGLGIRKEVDPELVVPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVD
FT                   TPWRKLPAKARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQM
FT                   KERYEGFMRDVPCPVCAGTRLKPEILAVTLAGESKGEHGAKSIAEVCELSIADCADFLN
FT                   ALTLGPREQAIAGQVLKEIRSRLGFLLDVGLEYLSLSRAAATLSGGEAQRIRLATQIGS
FT                   GLVGVLYVLDEPSIGLHQRDNRRLIETLTRLRDLGNTLIVVEHDEDTIEHADWIVDIGP
FT                   GAGEHGGRIVHSGPYDELLRNKDSITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREH
FT                   NLRGIDVSFPLGVLTSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLDY
FT                   LDKLVRVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRC
FT                   EACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTVSEVLDMSIEEAAEF
FT                   FEPIAGVHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTVYILDE
FT                   PTTGLHFDDIRKLLNVINGLVDKGNTVIVIEHNLDVIKTSDWIIDLGPEGGAGGGTVVA
FT                   QGTPEDVAAVPASYTGKFLAEVVGGGASAATSRSNRRRNVSA"
FT   misc_feature    112577..112600
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   misc_feature    113984..114028
FT                   /note="PS00211 ABC transporters family signature"
FT   misc_feature    114443..114466
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   misc_feature    115010..115054
FT                   /note="PS00211 ABC transporters family signature"
FT   CDS             complement(115459..115716)
FT                   /transl_table=11
FT                   /locus_tag="Rv1638A"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1638A, len: 85 aa. Conserved hypothetical protein,
FT                   similar to C-terminal part of P31511|35KD_MYCTU 35kd
FT                   immunogenic protein from Mycobacterium tuberculosis (270
FT                   aa), FASTA scores: opt: 159, E(): 0.002, (50.90% identity
FT                   in 55 aa overlap); and to Mycobacterium leprae ML0981
FT                   possible pseudogene, an orthologue of 35kd immunogenic
FT                   protein from Mycobacterium tuberculosis. Size difference
FT                   suggests possible gene fragment."
FT                   /db_xref="UniProtKB/TrEMBL:Q8VJZ6"
FT                   /protein_id="CAE55409.1"
FT                   /translation="MPDEPTPPEATTPNSESDPRYDSAGVPTFESVREKIETRYGTALG
FT                   ATELDAESPQGRRLEDQYAQRQRAAAERLAQIRESMHTDE"
FT   CDS             complement(115732..117201)
FT                   /transl_table=11
FT                   /locus_tag="Rv1639c"
FT                   /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1639c, (MTCY06H11.03c), len: 489 aa. Conserved
FT                   hypothetical membrane protein. Some similarity to
FT                   P35866|YLI2_CORGL Hypothetical 45.7 kDa protein from
FT                   Corynebacterium glutamicum (426 aa), FASTA scores: opt:
FT                   511, E( ): 2.4e-23, (28.9% identity in 370 aa overlap).
FT                   Contains PS00904 protein phenyltransferases alpha subunit
FT                   repeat signature"
FT                   /db_xref="InterPro:IPR000801"
FT                   /db_xref="UniProtKB/TrEMBL:P94973"
FT                   /protein_id="CAB06634.1"
FT                   /translation="MAQNELVTASTPPAATQPLAVGHTSLMHGWVPLAVQVVTAVVLVL
FT                   AAGWRSRHWQRRWLPTAAAIGATLAWGTRWYVTGNGLANERPPSTLWIWVALTGAAATV
FT                   LILGWRSARWWRRGASLLAVPLCLLSATLTLNLWVGYFPTVQTAWNQLTSGPLPDQADQ
FT                   AAVAALAHSGVRPSHGTLLPVVIPSDASHFKHRGELVYLPPAWFDREHRSENPPPPQLP
FT                   TVMMIGGQFNTPADWARAGNAVKTLDDFAAAHSGNAPVVVFVDSGGAFNNDTECVNGRR
FT                   GNAADHLTKDVVPYMVSKFGVSPEQTSWGIVGWSMGGTCAVDLTVMHPTLFSAFVDIAG
FT                   DFYPNAGNKTQTIVRLFGGNEDAWSAFDPTTVITRHGSYTGLSGWFAISSPGPPSPDNA
FT                   VADTTTMRLAGRDAAANPGNQAAAANALCALGRANGIYCAVVPQPGKHDWPFADRVFAA
FT                   ALPWLAGQLATPGVPKIPLPGTTQQIAGTGR"
FT   misc_feature    complement(116746..116775)
FT                   /note="PS00904 Protein prenyltransferases alpha subunit
FT                   repeat signature"
FT   CDS             complement(117260..120778)
FT                   /transl_table=11
FT                   /gene="lysX"
FT                   /locus_tag="Rv1640c"
FT                   /product="Possible lysyl-tRNA synthetase 2 lysX"
FT                   /function="charging Lys tRNA [CATALYTIC ACTIVITY: ATP +
FT                   L-LYSINE + TRNA(LYS) = AMP + DIPHOSPHATE +
FT                   L-LYSYL-TRNA(LYS)]"
FT                   /EC_number="6.1.1.6"
FT                   /note="Rv1640c, (MTCY06H11.04c), len: 1172 aa. Probable two
FT                   domain protein, possible lysyl-tRNA synthetase 2 (EC
FT                   6.1.1.6). N-terminal part (bases 1850153 to 1852033) is
FT                   similar to AL023861|SC3C8_3 hypothetical membrane protein
FT                   from Streptomyces coelicolor (589 aa), Fasta scores: opt:
FT                   1426, E(): 0, (44.6% identity in 585 aa overlap). The
FT                   C-terminal part is similar to SYK_CRILO|P37879 lysyl-tRNA
FT                   synthetases (EC 6.1.1.6) from Cricetulus longicaudatus
FT                   (Long-tailed hamster) (597 aa), Fasta scores, opt: 985,
FT                   E(): 0, (36.8% identity in 524 aa overlap ). Contains
FT                   PS00179 Aminoacyl-transfer RNA synthetases class-II
FT                   signature 1, PS00339 Aminoacyl-transfer RNA synthetases
FT                   class-II signature 2. This may indicate a frame shift but
FT                   sequence has been checked and no error found. BELONGS TO
FT                   CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY."
FT                   /db_xref="GOA:P94974"
FT                   /db_xref="HSSP:1BBW"
FT                   /db_xref="InterPro:IPR004365"
FT                   /db_xref="UniProtKB/Swiss-Prot:P94974"
FT                   /protein_id="CAB06635.1"
FT                   /translation="MGLHLTVPGLRRDGRGVQSNSHDTSSKTTADISRCPQHTDAGLQR
FT                   AATPGISRLLGISSRSVTLTKPRSATRGNSRYHWVPAAAGWTVGVIATLSLLASVSPLI
FT                   RWIIKVPREFINDYLFNFPDTNFAWSFVLALLAAALTARKRIAWLVLLANMVLAAVVNA
FT                   AEIAAGGNTAAESFGENLGFAVHVVAIVVLVLGYREFWAKVRRGALFRAAAVWLAGAVV
FT                   GIVASWGLVELFPGSLAPDERLGYAANRVVGFALADPDLFTGRPHVFLNAIFGLFGAFA
FT                   LIGAAIVLFLSQRADNALTGEDESAIRGLLDLYGKDDSLGYFATRRDKSVVFASSGRAC
FT                   ITYRVEVGVCLASGDPVGDHRAWPQAVDAWLRLCQTYGWAPGVMGASSQGAQTYREAGL
FT                   TALELGDEAILRPADFKLSGPEMRGVRQAVTRARRAGLTVRIRRHRDIAEDEMAQTITR
FT                   ADSWRDTETERGFSMALGRLGDPADSDCLLVEAIDPHNQVLAMLSLVPWGTTGVSLDLM
FT                   RRSPQSPNGTIELMVSELALHAESLGITRISLNFAVFRAAFEQGAQLGAGPVARLWRGL
FT                   LVFFSRWWQLETLYRSNMKYQPEWVPRYACYEDARVIPRVGVASVIAEGFLVLPFSRRN
FT                   RVHTGHHPAVPERLAATGLLHHDGSAPDVSGLRQVGLTNGDGVERRLPEQVRVRFDKLE
FT                   KLRSSGIDAFPVGRPPSHTVAQALAADHQASVSVSGRIMRIRNYGGVLFAQLRDWSGEM
FT                   QVLLDNSRLDQGCAADFNAATDLGDLVEMTGHMGASKTGTPSLIVSGWRLIGKCLRPLP
FT                   NKWKGLLDPEARVRTRYLDLAVNAESRALITARSSVLRAVRETLFAKGFVEVETPILQQ
FT                   LHGGATARPFVTHINTYSMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHN
FT                   PEFTLLEAYQAHADYLEWIDGCRELIQNAAQAANGAPIAMRPRTDKGSDGTRHHLEPVD
FT                   ISGIWPVRTVHDAISEALGERIDADTGLTTLRKLCDAAGVPYRTQWDAGAVVLELYEHL
FT                   VECRTEQPTFYIDFPTSVSPLTRPHRSKRGVAERWDLVAWGIELGTAYSELTDPVEQRR
FT                   RLQEQSLLAAGGDPEAMELDEDFLQAMEYAMPPTGGLGMGIDRVVMLITGRSIRETLPF
FT                   PLAKPH"
FT   misc_feature    complement(117317..117346)
FT                   /note="PS00339 Aminoacyl-transfer RNA synthetases class-II
FT                   signature 2"
FT   misc_feature    complement(117968..118021)
FT                   /note="PS00179 Aminoacyl-transfer RNA synthetases class-II
FT                   signature 1"
FT   CDS             121016..121621
FT                   /transl_table=11
FT                   /gene="infC"
FT                   /locus_tag="Rv1641"
FT                   /product="PROBABLE INITIATION FACTOR IF-3 INFC"
FT                   /function="IF-3 BINDS TO THE 30S RIBOSOMAL SUBUNIT AND
FT                   SHIFTS THE EQUILIBRUM BETWEEN 70S RIBOSOMES AND THEIR 50S
FT                   AND 30S SUBUNITS IN FAVOR OF THE FREE SUBUNITS, THUS
FT                   ENHANCING THE AVAILABILITY OF 30S SUBUNITS ON WHICH PROTEIN
FT                   SYNTHESIS INITIATION BEGINS."
FT                   /note="Rv1641, (MTCY06H11.05), len: 201 aa. Probable infC,
FT                   initiation factor IF-3, similar to many e.g.
FT                   IF3_BACST|P03000 initiation factor IF-3 from Bacillus
FT                   stearothermophilus (171 aa), FASTA scores: opt: 560, E():
FT                   1.9e-27, (50.6% identity in 166 aa overlap). Note that an
FT                   AUC initiation codon has been used, the Bacillus
FT                   (IF3_BACSU) and Escherichia coli (IF3_ECOLI) proteins use
FT                   an AUU initiation codon, and the Myxococcus xanthus
FT                   (DSG_MYXXA) homolog uses a AUC. BELONGS TO THE IF-3
FT                   FAMILY."
FT                   /db_xref="GOA:P65135"
FT                   /db_xref="HSSP:2IFE"
FT                   /db_xref="InterPro:IPR019814"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65135"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06651.1"
FT                   /translation="MSTETRVNERIRVPEVRLIGPGGEQVGIVRIEDALRVAADADLDL
FT                   VEVAPNARPPVCKIMDYGKYKYEAAQKARESRRNQQQTVVKEQKLRPKIDDHDYETKKG
FT                   HVVRFLEAGSKVKVTIMFRGREQSRPELGYRLLQRLGADVADYGFIETSAKQDGRNMTM
FT                   VLAPHRGAKTRARARHPGEPAGGPPPKPTAGDSKAAPN"
FT   CDS             121671..121865
FT                   /transl_table=11
FT                   /gene="rpmI"
FT                   /locus_tag="Rv1642"
FT                   /product="Probable 50S ribosomal protein L35 RpmI"
FT                   /function="translation"
FT                   /note="Rv1642, (MTCY06H11.06), len: 64 aa. Probable rpmI,
FT                   50S ribosomal protein L35, similar to several e.g.
FT                   RL35_SYNY3|P48959 from Synechocystis sp. (67 aa), fasta
FT                   scores: opt: 179, E(): 2.7e-08, (51.6% identity in 64 aa
FT                   overlap). BELONGS TO THE L35P FAMILY OF RIBOSOMAL
FT                   PROTEINS."
FT                   /db_xref="GOA:P66271"
FT                   /db_xref="InterPro:IPR018265"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66271"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06636.1"
FT                   /translation="MPKAKTHSGASKRFRRTGTGKIVRQKANRRHLLEHKPSTRTRRLD
FT                   GRTVVAANDTKRVTSLLNG"
FT   CDS             121927..122316
FT                   /transl_table=11
FT                   /gene="rplT"
FT                   /locus_tag="Rv1643"
FT                   /product="Probable 50S ribosomal protein L20 RplT"
FT                   /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL RNA
FT                   AND IS NECESSARY TO THE IN VITRO ASSEMBLY PROCESS OF THE
FT                   50S RIBOSOMAL SUBUNIT; IT IS NOT INVOLVED IN THE PROTEIN
FT                   SYNTHESIZING FUNCTIONS OF THAT SUBUNIT"
FT                   /note="Rv1643, (MTCY06H11.07), len: 129 aa. Probable rplT,
FT                   50S ribosomal protein L20, similar to several e.g.
FT                   RL20_ECOLI|P02421 from Escherichia coli (117 aa), FASTA
FT                   scores: opt: 438, E(): 5.8e-24, (60.3% identity in 116 aa
FT                   overlap). Contains PS00937 Ribosomal protein L20
FT                   signature."
FT                   /db_xref="GOA:P66105"
FT                   /db_xref="HSSP:1GYZ"
FT                   /db_xref="InterPro:IPR005812"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66105"
FT                   /protein_id="CAB06637.1"
FT                   /translation="MARVKRAVNAHKKRRSILKASRGYRGQRSRLYRKAKEQQLHSLNY
FT                   AYRDRRARKGEFRKLWIARINAAARLNDITYNRLIQGLKAAGVEVDRKNLADIAISDPA
FT                   AFTALVDVARAALPEDVNAPSGEAA"
FT   misc_feature    122086..122136
FT                   /note="PS00937 Ribosomal protein L20 signature"
FT   CDS             122349..123131
FT                   /transl_table=11
FT                   /gene="tsnR"
FT                   /locus_tag="Rv1644"
FT                   /product="Possible 23S rRNA methyltransferase tsnR"
FT                   /function="rRNA modification"
FT                   /EC_number="2.1.1.-"
FT                   /note="Rv1644, (MTCY06H11.08), len: 260 aa. Possible tsnR,
FT                   23S rRNA methyltransferase (EC 2.1.1.-), similar to several
FT                   e.g. TSNR_STRLU|P52393 from Streptomyces laurentii (270
FT                   aa), FASTA scores: opt: 276, E(): 3.6e-11, (27.6% identity
FT                   in 261 aa overlap). Also similar to M. tuberculosis
FT                   hypothetical proteins Rv0881, Rv3579c, and Rv0380c."
FT                   /db_xref="GOA:P94978"
FT                   /db_xref="InterPro:IPR013123"
FT                   /db_xref="UniProtKB/TrEMBL:P94978"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06638.1"
FT                   /translation="MLTERSARVATAVKLHRHVGRRRAGRFLAEGPNLVAAALARGLVR
FT                   EVFVTEVAARRHELLLAAHEASVHLVTERAAKALSDTVTPAGLVAVCDLPATRLEDVLA
FT                   GSPQLIAVTVEIREPGNAGTVIRIADAMGAAAVILAGRSVDPYNGKCLRASTGSIFAIP
FT                   VVVAPDVGAAIADLRAAGLQVLATAVDGEMALDDADRLLAEPTAWLFGPEAHGLSAEIA
FT                   ALADHRVHILMSGGAESLNVAAAAAICLYESARALGRR"
FT   CDS             complement(123142..124197)
FT                   /transl_table=11
FT                   /locus_tag="Rv1645c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1645c, (MTCY06H11.10c), len: 351 aa. Conserved
FT                   hypothetical protein, similar to other Mycobacterium
FT                   tuberculosis hypothetical proteins e.g.
FT                   O53837|Rv0826|MTV043.18 (351 aa), FASTA scores: (57.5%
FT                   identity in 299 aa overlap); Q10519|Rv2237|YM37_MYCTU (255
FT                   aa), O53682|Rv0276 (306 aa)."
FT                   /db_xref="InterPro:IPR018713"
FT                   /db_xref="UniProtKB/TrEMBL:P94979"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06639.1"
FT                   /translation="MTVASRTSADPLGPDSLTWKYFGDLRTGMMGVWIGAIQNMYPELG
FT                   AGVEEHSILLREPLQRVARSVYPIMGVVYDGDRAAQTGQQIKGYHRTIKGVDAEGRRYH
FT                   ALNPDTFYWAHATFFMLVIKVAEYFCGGLTEAEKHQLFEEHVRWYRMYGMSMRPVPKSW
FT                   EDFQDYWDRVCRDKLEINQATVDILQMRIPKPRFVLMPTPIWDQLFKPLIAGQRWIAAG
FT                   LFDPAVREKAGMHWTPGDEVLLRVFGKVVELAFLAVPDEIRLHPRALAAYRRAAGRTRH
FT                   DAPLVQAPGFMAPPRDRQGLPMHYFPPRSHRFTRSALDPAKALMERAGALVHSTLSLAG
FT                   VRPARGPSRAA"
FT   CDS             124507..125439
FT                   /transl_table=11
FT                   /gene="PE17"
FT                   /locus_tag="Rv1646"
FT                   /product="PE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1646, (MTCY06H11.11), len: 310 aa. Member of the
FT                   Mycobacterium tuberculosis PE family of proteins (see
FT                   citation below), similar to many e.g. YW36_MYCTU|Q10873
FT                   hypothetical 53.7 kd protein cy39.36c (558 aa), FASTA
FT                   scores, opt: 411, E(): 1.3e-15, (34.4% identity in 320 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D879"
FT                   /protein_id="CAE55410.1"
FT                   /translation="MSFLTVAPDMVTAAAGNLESVGSALNEAAAAAAPATVGLAAPAAD
FT                   RVSAVVAAMLGAYARDFQGISAQIAGFHNQFVGALRGGAAAYASAEAANVQQTVVNAVN
FT                   APAQALLGHPLIGPETVGSSAAAVSFGFGPLLLAGSDPLLAVPFSYPASLPTPFGPVTM
FT                   TLNGSFDPLTQQVVFDSGSLTAPAPFVYGLGAVGPALTTMTALQNSGTAFSGAVQSGNL
FT                   LGAAGALLQAPGNAVTGFLFGQTAISQSIPGPSNLGYESVGISVPVGGLLAPLQPVTVT
FT                   LTPTSGMPTAIQLSGTQFGGLLPALLNGF"
FT   CDS             125517..126467
FT                   /transl_table=11
FT                   /locus_tag="Rv1647"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1647, (MTCY06H11.12), len: 316 aa. Conserved
FT                   hypothetical protein, some similarity to other
FT                   Mycobacterium tuberculosis hypothetical proteins e.g.
FT                   Q11055|Rv1264|YC64_MYCTU Hypothetical 42.2 kDa protein (397
FT                   aa), FASTA scores: opt: 197, E(): 9.4e-06, (27.1% identity
FT                   in 181 aa overlap) and Q10400|Rv2212|YM12_MYCTU (378 aa)."
FT                   /db_xref="GOA:P94982"
FT                   /db_xref="InterPro:IPR001054"
FT                   /db_xref="UniProtKB/TrEMBL:P94982"
FT                   /protein_id="CAB06641.1"
FT                   /translation="MAGSARTTYPCHVEVGPQDSESGAPDETATAMASPVPRQRSALRW
FT                   LRTVNRSPGLVSFIHRARRLLPGDPEFGDPLSTAGEGGPRAAARAADRLLRDRDAASRE
FT                   VGLSVLQVWQALTEAVSRRPANPEVTLVFTDLVGFSTWSLHAGDDATLTLLRQVARAVE
FT                   SPLLDAGGHIVKRLGDGIMAVFRNPTVALRAVLVAQDAVKSLEVQGYTPRMRIGIHTGR
FT                   PQRLAADWLGVDVNIAARVMERATKGGIMISQPTLDLIPQSELDALGVVARRVRKPVFA
FT                   SKPTGIPPDLAIYRIKTVSESTAADNFDEMSPDAQ"
FT   CDS             126474..127280
FT                   /transl_table=11
FT                   /locus_tag="Rv1648"
FT                   /product="Probable transmembrane protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1648, (MTCY06H11.13), len: 268 aa. Probable
FT                   transmembrane protein, some similarity to
FT                   Rv3434c|MTCY77.06C (237 aa), FASTA scores: E(): 0.00039,
FT                   (31.4% identity in 194 aa overlap)."
FT                   /db_xref="GOA:P94983"
FT                   /db_xref="UniProtKB/TrEMBL:P94983"
FT                   /protein_id="CAB06642.1"
FT                   /translation="MIYRVACLLARIRFTVGYVAALASVSTTILMHGPQVHAQVIRHAS
FT                   TNLHNLAHGHLGTLWNSAFVIDEGPLYFWLPCLACLLAVAELQLRSLRLTVAFVVGHIG
FT                   ATLLVAAVLAGAIEIGWLPWSISRVSDVGMSYGALAALGALTAAIPGRWRPAWIGWWVS
FT                   LGLATATIGGGFTDAGHTVALLLGMLVTACFTRPARWTLGRCALLAVASGFCLVLLAHS
FT                   WWSLVSGSALGLLGALGAAGFARWTRARATSLPPGALAIPQPALSR"
FT   CDS             127476..128501
FT                   /transl_table=11
FT                   /gene="pheS"
FT                   /locus_tag="Rv1649"
FT                   /product="Probable phenylalanyl-tRNA synthetase, alpha
FT                   chain PheS"
FT                   /function="charging phe tRNA [CATALYTIC ACTIVITY : ATP +
FT                   L-PHENYLALANINE + TRNA(PHE) = AMP + DIPHOSPHATE +
FT                   L-PHENYLALANYL-TRNA(PHE)]"
FT                   /EC_number="6.1.1.20"
FT                   /note="Rv1649, (MTCY06H11.14), len: 341 aa. Probable pheS,
FT                   Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20),
FT                   similar to several e.g. SYFA_ECOLI|P08312 from Escherichia
FT                   coli (327 aa), FASTA scores: opt: 978, E(): 0, (46.5%
FT                   identity in 331 aa overlap). Homology suggests this start
FT                   site, but there is a potential rbs upstream of a gtg 30 bp
FT                   upstream; contains PS00179 Aminoacyl-transfer RNA
FT                   synthetases class-II signature 1. BELONGS TO CLASS-II
FT                   AMINOACYL-TRNA SYNTHETASE FAMILY. PHE-TRNA SYNTHETASE ALPHA
FT                   CHAIN SUBFAMILY 1."
FT                   /db_xref="GOA:P94984"
FT                   /db_xref="HSSP:1JJC"
FT                   /db_xref="InterPro:IPR004188"
FT                   /db_xref="UniProtKB/Swiss-Prot:P94984"
FT                   /protein_id="CAB06643.1"
FT                   /translation="MLSPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALAR
FT                   QALAVLPKEQRAEAGKRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVTLPSTRV
FT                   PAGARHPIIMLAEHVADTFIAMGWELAEGPEVETEQFNFDALNFPADHPARGEQDTFYI
FT                   APEDSRQLLRTHTSPVQIRTLLARELPVYIISIGRTFRTDELDATHTPIFHQVEGLAVD
FT                   RGLSMAHLRGTLDAFARAEFGPSARTRIRPHFFPFTEPSAEVDVWFANKIGGAAWVEWG
FT                   GCGMVHPNVLRATGIDPDLYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVG
FT                   A"
FT   misc_feature    128073..128126
FT                   /note="PS00179 Aminoacyl-transfer RNA synthetases class-II
FT                   signature 1"
FT   CDS             128501..130996
FT                   /transl_table=11
FT                   /gene="pheT"
FT                   /locus_tag="Rv1650"
FT                   /product="Probable phenylalanyl-tRNA synthetase, beta chain
FT                   PheT"
FT                   /function="charging phe-tRNA [CATALYTIC ACTIVITY : ATP +
FT                   L-PHENYLALANINE + TRNA(PHE) = AMP + DIPHOSPHATE +
FT                   L-PHENYLALANYL-TRNA(PHE)]"
FT                   /EC_number="6.1.1.20"
FT                   /note="Rv1650, (MTCY06H11.15), len: 831 aa. Probable pheT,
FT                   Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20),
FT                   similar to several e.g. SYFB_ECOLI|P07395 from Escherichia
FT                   coli (795 aa), FASTA scores: opt: 995, E(): 0, (31.8%
FT                   identity in 847 aa overlap). BELONGS TO THE
FT                   PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN FAMILY - SUBFAMILY
FT                   1."
FT                   /db_xref="GOA:P94985"
FT                   /db_xref="HSSP:1JJC"
FT                   /db_xref="InterPro:IPR002547"
FT                   /db_xref="UniProtKB/Swiss-Prot:P94985"
FT                   /protein_id="CAB06644.1"
FT                   /translation="MRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGP
FT                   VDGPVTVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDLVVVALPGAT
FT                   LPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPPGAAEPGADGAGVLGLDDV
FT                   VFHLAITPDRGYCMSVRGLARELACAYDLDFVDPASNSRVPPLPIEGPAWPLTVQPETG
FT                   VRRFALRPVIGIDPAAVSPWWLQRRLLLCGIRATCPAVDVTNYVMLELGHPMHAHDRNR
FT                   ISGTLGVRFARSGETAVTLDGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTD
FT                   VLLEAAIWDPAAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLADIAGGEVS
FT                   PTLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQIGAVVTHDGDTLT
FT                   VTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAPAGRGLTAGQQRRRTIGRSLALS
FT                   GYVEILPTPFLPAGVFDLWGLEADDSRRMTTRVLNPLEADRPQLATTLLPALLEALVRN
FT                   VSRGLVDVALFAIAQVVQPTEQTRGVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLA
FT                   GLREPRGPWGPGRPVEAADAFEAVRIIARASRVDVTLRPAQYLPWHPGRCAQVFVGESS
FT                   VGHAGQLHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYPAVFQDVSLVVAAD
FT                   IPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFALRFRAPDRTLTEDDASA
FT                   ARDAAVQSAAERVGAVLRG"
FT   CDS             complement(131090..134125)
FT                   /transl_table=11
FT                   /gene="PE_PGRS30"
FT                   /locus_tag="Rv1651c"
FT                   /product="PE-PGRS FAMILY PROTEIN"
FT                   /function="UNKNOWN. THOUGHT TO BE INVOLVED IN VIRULENCE."
FT                   /note="Rv1651c, (MTCY06H11.16c), len: 1011 aa. Member of
FT                   the Mycobacterium tuberculosis PE family, PGRS subfamily of
FT                   gly-rich proteins (see citations below), similar to many
FT                   e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kd
FT                   protein (603 aa), FASTA scores: opt: 1757, E(): 0, (50.8%
FT                   identity in 714aa overlap). The transcription of this CDS
FT                   seems to be activated in macrophages (see Ramakrishnan et
FT                   al., 2000)."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FL8"
FT                   /protein_id="CAE55411.1"
FT                   /translation="MSFLLVEPDLVTAAAANLAGIRSALSEAAAAASTPTTALASAGAD
FT                   EVSAAVSRLFGAYGQQFQALNARAATFHAEFVSLLNGGAAAYTGAEAASVSSMQALLDA
FT                   VNAPTQTLLGRPLIGNGADGVAGTGSNAGGNGGPGGILYGNGGNGGAGGNGGAAGLIGN
FT                   GGAGGAGGAGGAGGAGGAGGTGGLLYGNGGAGGNGGSAAAAGGAGGNALLFGNGGNGGS
FT                   GASGGAAGHAGTIFGNGGNAGAGSGLAGADGGLFGNGGDGGSSTSKAGGAGGNALFGNG
FT                   GDGGSSTVAAGGAGGNTLVGNGGAGGAGGTSGLTGSGVAGGAGGSVGLWGSGGAGGDGG
FT                   AATSLLGVGMNAGAGGAGGNAGLLYGNGGAGGAGGNGGDTTVPLFDSGVGGAGGAGGNA
FT                   SLFGNGGTGGVGGKGGTSSDLASATSGAGGAGGAGGVGGLLYGNGGNGGAGGIGGAAIN
FT                   ILANAGAGGAGGAAGSSFIGNGGNGGAGGAGGAAALFSSGVGGAGGSGGTALLLGSGGA
FT                   GGNGGTGGANSGSLFASPGGTGGAGGHGGAGGLIWGNGGAGGNGGNGGTTADGALEGGT
FT                   GGIGGTGGSAIAFGNGGQGGAGGTGGDHSGGNGIGGKGGASGNGGNAGQVFGDGGTGGT
FT                   GGAGGAGSGTKAGGTGSDGGHGGNATLIGNGGDGGAGGAGGAGSPAGAPGNGGTGGTGG
FT                   VLFGQSGSSGPPGAAALAFPSLSSSVPILGPYEDLIANTVANLASIGNTWLADPAPFLQ
FT                   QYLANQFGYGQLTLTALTDATRDFAIGLAGIPPSLQSALQALAAGDVSGAVTDVLGAVV
FT                   KVFVSGVDASDLSNILLLGPVGDLFPILSIPGAMSQNFTNVVMTVTDTTIAFSIDTTNL
FT                   TGVMTFGLPLAMTLNAVGSPITTAIAFAESTTAFVSAVQAGNLQAAAAALVGAPANVAN
FT                   GFLNGEARLPLALPTSATGGIPVTVEVPVGGILAPLQPFQATAVIPVIGPVTVTLEGTP
FT                   AGGIVPALVNYAPTQLAQAIAP"
FT   CDS             134319..135377
FT                   /transl_table=11
FT                   /gene="argC"
FT                   /locus_tag="Rv1652"
FT                   /product="PROBABLE N-ACETL-GAMMA-GLUTAMYL-PHOSHATE
FT                   REDUCTASE ARGC"
FT                   /function="INVOLVED IN ARGININE BIOSYNTHESIS (AT THE THIRD
FT                   STEP) [CATALYTIC ACTIVITY : N-ACETYL-L-GLUTAMATE
FT                   5-SEMIALDEHYDE + NADP(+) + PHOSPHATE = N-ACETYL-5-GLUTAMYL
FT                   PHOSPHATE + NADPH]."
FT                   /EC_number="1.2.1.38"
FT                   /note="Rv1652, (MTCY06H11.17), len: 352 aa. Probable argC,
FT                   N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38),
FT                   similar to many e.g. ARGC_STRCL|P54896 from Streptomyces
FT                   clavuligerus (340 aa) , FASTA scores: opt: 1119, E(): 0,
FT                   (56.9% identity in 350 aa overlap); etc. BELONGS TO THE
FT                   NAGSA DEHYDROGENASE FAMILY."
FT                   /db_xref="GOA:P63562"
FT                   /db_xref="InterPro:IPR012280"
FT                   /db_xref="PDB:2I3A"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63562"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06646.1"
FT                   /translation="MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGAL
FT                   TAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPET
FT                   LIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYPTAA
FT                   LLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPE
FT                   IAQGLRAVTDRDVSVSFTPVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYL
FT                   MPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMNLALGWP
FT                   ETDGLSVVGVAP"
FT   CDS             135374..136588
FT                   /transl_table=11
FT                   /gene="argJ"
FT                   /locus_tag="Rv1653"
FT                   /product="Probable Glutamate n-acetyltransferase argJ"
FT                   /function="ARGININE BIOSYNTHESIS."
FT                   /EC_number="2.3.1.35"
FT                   /note="Rv1653, (MTCY06H11.18), len: 404 aa. Probable argJ,
FT                   Glutamate n-acetyltransferase (EC 2.3.1.35), similar to
FT                   ARGJ_BACSU|P36843 from Bacillus subtilis (406 aa), fasta
FT                   scores: opt: 727, E(): 0, (36.3% identity in 410 a a
FT                   overlap)."
FT                   /db_xref="GOA:P63571"
FT                   /db_xref="InterPro:IPR002813"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63571"
FT                   /protein_id="CAB06647.1"
FT                   /translation="MTDLAGTTRLLRAQGVTAPAGFRAAGVAAGIKASGALDLALVFNE
FT                   GPDYAAAGVFTRNQVKAAPVLWTQQVLTTGRLRAVILNSGGANACTGPAGFADTHATAE
FT                   AVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKLLAGVAHVVHEMHGGLVGGDEAAHA
FT                   IMTTDNVPKQVALHHHDNWTVGGMAKGAGMLAPSLATMLCVLTTDAAAEPAALERALRR
FT                   AAAATFDRLDIDGSCSTNDTVLLLSSGASEIPPAQADLDEAVLRVCDDLCAQLQADAEG
FT                   VTKRVTVTVTGAATEDDALVAARQIARDSLVKTALFGSDPNWGRVLAAVGMAPITLDPD
FT                   RISVSFNGAAVCVHGVGAPGAREVDLSDADIDITVDLGVGDGQARIRTTDLSHAYVEEN
FT                   SAYSS"
FT   CDS             136585..137469
FT                   /transl_table=11
FT                   /gene="argB"
FT                   /locus_tag="Rv1654"
FT                   /product="Probable Acetylglutamate kinase argB"
FT                   /function="ARGININE BIOSYNTHESIS (SECOND STEP) [CATALYTIC
FT                   ACTIVITY : ATP + N-ACETYL-L-GLUTAMATE = ADP +
FT                   N-ACETYL-L-GLUTAMATE 5-PHOSPHATE]"
FT                   /EC_number="2.7.2.8"
FT                   /note="Rv1654, (MTCY06H11.19), len: 294 aa. Probable argB,
FT                   Acetylglutamate kinase (EC 2.7.2.8), similar to
FT                   ARGB_CORGL|Q59281 (294 aa), FASTA scores: opt: 1209, E():
FT                   0, (64.4% identity in 270 aa overlap). BELONGS TO THE
FT                   ACETYLGLUTAMATE KINASE FAMILY."
FT                   /db_xref="GOA:P0A4Y6"
FT                   /db_xref="InterPro:IPR001057"
FT                   /db_xref="PDB:2AP9"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A4Y6"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06648.1"
FT                   /translation="MSRIEALPTHIKAQVLAEALPWLKQLHGKVVVVKYGGNAMTDDTL
FT                   RRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIEGDFKGGFRVTTPEVLDVARMV
FT                   LFGQVGRELVNLINAHGPYAVGITGEDAQLFTAVRRSVTVDGVATDIGLVGDVDQVNTA
FT                   AMLDLVAAGRIPVVSTLAPDADGVVHNINADTAAAAVAEALGAEKLLMLTDIDGLYTRW
FT                   PDRDSLVSEIDTGTLAQLLPTLESGMVPKVEACLRAVIGGVPSAHIIDGRVTHCVLVEL
FT                   FTDAGTGTKVVRG"
FT   CDS             137466..138668
FT                   /transl_table=11
FT                   /gene="argD"
FT                   /locus_tag="Rv1655"
FT                   /product="Probable Acetylornithine aminotransferase argD"
FT                   /function="ARGININE BIOSYNTHESIS (FOURTH STEP) [CATALYTIC
FT                   ACTIVITY :N2-ACETYL-L-ORNITHINE + 2-OXOGLUTARATE =
FT                   N-ACETYL-L-GLUTAMATE 5-SEMIALDEHYDE + L-GLUTAMATE]"
FT                   /EC_number="2.6.1.11"
FT                   /note="Rv1655, (MTCY06H11.20), len: 400 aa. Probable argD,
FT                   Acetylornithine aminotransferase (EC 2.6.1.11), similar to
FT                   ARGD_ECOLI|P18335 (406 aa), FASTA scores: opt: 958, E(): 0,
FT                   (38.6% identity in 404 aa overlap), contains PS00600
FT                   Aminotransferases class-III pyridoxal-phosphate attachment
FT                   site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT
FT                   AMINOTRANSFERASES."
FT                   /db_xref="GOA:P63568"
FT                   /db_xref="HSSP:1QJ3"
FT                   /db_xref="InterPro:IPR015421"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63568"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06649.1"
FT                   /translation="MTGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGRT
FT                   YIDLLGGIAVNVLGHRHPAVIEAVTRQMSTLGHTSNLYATEPGIALAEELVALLGADQR
FT                   TRVFFCNSGAEANEAAFKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFAPLP
FT                   GDVTHVGYGDVDALAAAVDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRGALLV
FT                   LDEVQTGMGRTGAFFAHQHDGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTPGLHGS
FT                   TFGGNPVCAAAALAVLRVLASDGLVRRAEVLGKSLRHGIEALGHPLIDHVRGRGLLLGI
FT                   ALTAPHAKDAEATARDAGYLVNAAAPDVIRLAPPLIIAEAQLDGFVAALPAILDRAVGA
FT                   P"
FT   misc_feature    138126..138239
FT                   /note="PS00600 Aminotransferases class-III
FT                   pyridoxal-phosphate attachment site"
FT   CDS             138665..139588
FT                   /transl_table=11
FT                   /gene="argF"
FT                   /locus_tag="Rv1656"
FT                   /product="Probable Ornithine carbamoyltransferase, anabolic
FT                   ArgF"
FT                   /function="INVOLVED IN ARGININE BIOSYNTHESIS [CATALYTIC
FT                   ACTIVITY : CARBAMOYL PHOSPHATE + L-ORNITHINE = PHOSPHATE +
FT                   L-CITRULLINE.]"
FT                   /EC_number="2.1.3.3"
FT                   /note="Rv1656, (MTCY06H11.21), len: 307 aa. Probable argF,
FT                   ornithine carbamoyltransferase, anabolic (EC 2.1.3.3) (see
FT                   citation below), almost identical to OTCA_MYCBO|Q02095
FT                   ornithine carbamoyltransferase, anabolic from Mycobacterium
FT                   bovis (307 aa), FASTA scores: opt: 1980, E(): 0, (99.0%
FT                   identity in 307 aa overlap); contains PS00097 Aspartate and
FT                   ornithine carbamoyltransferases signature. BELONGS TO THE
FT                   ATCASES/OTCASES FAMILY."
FT                   /db_xref="GOA:P0A5M8"
FT                   /db_xref="InterPro:IPR002292"
FT                   /db_xref="PDB:2I6U"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5M8"
FT                   /protein_id="CAB06650.1"
FT                   /translation="MIRHFLRDDDLSPAEQAEVLELAAELKKDPVSRRPLQGPRGVAVI
FT                   FDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRTFG
FT                   QERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANNMAH
FT                   SLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLV
FT                   TDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGP
FT                   ASAVWDEAENRLHAQKALLVWLLERS"
FT   misc_feature    138800..138823
FT                   /note="PS00097 Aspartate and ornithine
FT                   carbamoyltransferases signature"
FT   CDS             139585..140097
FT                   /transl_table=11
FT                   /gene="argR"
FT                   /locus_tag="Rv1657"
FT                   /standard_name="ahrC"
FT                   /product="Probable Arginine repressor argR (AHRC)"
FT                   /function="REGULATES ARGININE BIOSYNTHESIS GENES"
FT                   /note="Rv1657, (MTCY06H11.22), len: 170 aa. Probable argR,
FT                   Arginine repressor (alternate gene name: ahrC). Similar to
FT                   AHRC_BACSU|P17893 arginine hydroximate resistance protein
FT                   from Bacillus subtilis (149 aa), FASTA scores: opt: 283,
FT                   E(): 1.8e-11, (34.5% identity in 142 aa overlap); and
FT                   ARGR_ECOLI|P15282 arginine repressor from Escherichia coli
FT                   ( 156 aa), FASTA scores: opt: 194, E(): 6.4e-06, (30.8%
FT                   identity in 146 aa overlap). BELONGS TO THE ARGR FAMILY."
FT                   /db_xref="GOA:P0A4Y8"
FT                   /db_xref="InterPro:IPR011991"
FT                   /db_xref="PDB:2ZFZ"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A4Y8"
FT                   /protein_id="CAB06628.1"
FT                   /translation="MSRAKAAPVAGPEVAANRAGRQARIVAILSSAQVRSQNELAALLA
FT                   AEGIEVTQATLSRDLEELGAVKLRGADGGTGIYVVPEDGSPVRGVSGGTDRMARLLGEL
FT                   LVSTDDSGNLAVLRTPPGAAHYLASAIDRAALPQVVGTIAGDDTILVVAREPTTGAQLA
FT                   GMFENLR"
FT   CDS             140106..141302
FT                   /transl_table=11
FT                   /gene="argG"
FT                   /locus_tag="Rv1658"
FT                   /product="Probable Argininosuccinate synthase argG"
FT                   /function="ARGININE BIOSYNTHESIS [CATALYTIC ACTIVITY : ATP
FT                   + L-CITRULLINE + L-ASPARTATE = AMP + DIPHOSPHATE +
FT                   L-ARGININOSUCCINATE]"
FT                   /EC_number="6.3.4.5"
FT                   /note="Rv1658, (MTCY06H11.23), len: 398 aa. Probable argG,
FT                   Argininosuccinate synthase (EC 6.3.4.5), similar to
FT                   ASSY_STRCL|P50986 argininosuccinate synthase from
FT                   Streptomyces clavuligerus (397 aa), FASTA scores: opt:
FT                   1873, E(): 0, (67.8% identity in 397 aa overlap); contains
FT                   PS00564 Argininosuccinate synthase signature 1, PS00565
FT                   Argininosuccinate synthase signature 2. BELONGS TO THE
FT                   ARGININOSUCCINATE SYNTHASE FAMILY."
FT                   /db_xref="GOA:P63642"
FT                   /db_xref="HSSP:1KP2"
FT                   /db_xref="InterPro:IPR014729"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63642"
FT                   /protein_id="CAB06629.1"
FT                   /translation="MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEHMD
FT                   VIRQRALDCGAVEAVVVDARDEFAEGYCLPTVLNNALYMDRYPLVSAISRPLIVKHLVA
FT                   AAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENA
FT                   IPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDIYAYTEDPTINWGVPDEVIVGF
FT                   ERGVPVSVDGKPVSMLAAIEELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLI
FT                   TAHTELEHVTLERELGRFKRQTDQRWAELVYDGLWYSPLKAALEAFVAKTQEHVSGEVR
FT                   LVLHGGHIAVNGRRSAESLYDFNLATYDEGDSFDQSAARGFVYVHGLSSKLAARRDLR"
FT   misc_feature    140127..140153
FT                   /note="PS00564 Argininosuccinate synthase signature 1"
FT   misc_feature    140454..140489
FT                   /note="PS00565 Argininosuccinate synthase signature 2"
FT   CDS             141382..142794
FT                   /transl_table=11
FT                   /gene="argH"
FT                   /locus_tag="Rv1659"
FT                   /product="Probable Argininosuccinate lyase argH"
FT                   /function="ARGININE BIOSYNTHESIS (LAST STEP) [CATALYTIC
FT                   ACTIVITY : N-(L-ARGININO)SUCCINATE = FUMARATE + L-
FT                   ARGININE]"
FT                   /EC_number="4.3.2.1"
FT                   /note="Rv1659, (MTCY06H11.24), len: 470 aa. Probable argH,
FT                   Argininosuccinate lyase (EC 4.3.2.1), similar to
FT                   ARLY_ECOLI|P11447 argininosuccinate lyase from Escherichia
FT                   coli (457 aa), FASTA scores: opt: 1091, E(): 0, (42.5%
FT                   identity in 461 aa overlap); contains PS00017
FT                   ATP/GTP-binding site motif A, PS00163 Fumarate lyases
FT                   signature. BELONGS TO THE LYASE 1 FAMILY. ARGININOSUCCINATE
FT                   LYASE SUBFAMILY."
FT                   /db_xref="GOA:P0A4Z0"
FT                   /db_xref="HSSP:1AOS"
FT                   /db_xref="InterPro:IPR000362"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A4Z0"
FT                   /protein_id="CAB06630.1"
FT                   /translation="MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAH
FT                   TMVLFRAGLLTEEQRDGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRVGPDL
FT                   GGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAAHPSAIMPGKTHLQ
FT                   SAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAADLG
FT                   FSAAADNSVDATAARDFAAEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWSTG
FT                   SSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQL
FT                   ELLLPAMAGLVASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRA
FT                   AEQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRVAEQLNAIG
FT                   EAAERLRRQLVR"
FT   misc_feature    142222..142251
FT                   /note="PS00163 Fumarate lyases signature"
FT   misc_feature    142261..142284
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   CDS             142903..143964
FT                   /transl_table=11
FT                   /gene="pks10"
FT                   /locus_tag="Rv1660"
FT                   /product="Possible chalcone synthase pks10"
FT                   /function="Possibly involved in the biosynthesis of
FT                   Secondary Metabolites [CATALYTIC ACTIVITY: 3 Malonyl-CoA +
FT                   4-Coumaroyl-CoA = 4 CoA + Naringenin chalcone + 3 CO2]"
FT                   /EC_number="2.3.1.74"
FT                   /note="Rv1660, (MTCY06H11.25), len: 353 aa. Possible pks10,
FT                   chalcone synthase (EC 2.3.1.74), similar to
FT                   BCSA_BACSU|P54157 putative chalcone synthase from B.
FT                   subtilis (365 aa), FASTA scores: opt: 701, E(): 0, (33.1%
FT                   identity in 362 aa overlap). Also similar to M.
FT                   tuberculosis Rv1665|pks11 polyketide synthase (chalcone
FT                   synthase); and Rv1372|pks18 polyketide synthase. Other
FT                   upstream initiation sites are possible but homology
FT                   suggests this start."
FT                   /db_xref="GOA:P94995"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="UniProtKB/TrEMBL:P94995"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06631.1"
FT                   /translation="MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQLHASA
FT                   KVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDESGLRPEDLDVLITA
FT                   TVTGLAVPSLDARIAGRLGLRADVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGVAALV
FT                   SVELCSLTYPGYKPTLPGLVGSALFADGAAAVVAAGVKRAQDIGADGPDILDSRSHLYP
FT                   DSLRTMGYDVGSAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGP
FT                   KIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKPPPSGSPGLMIAMG
FT                   PGFCSELVLLRWH"
FT   CDS             144047..150427
FT                   /transl_table=11
FT                   /gene="pks7"
FT                   /locus_tag="Rv1661"
FT                   /product="Probable polyketide synthase pks7"
FT                   /function="POTENTIALLY INVOLVED IN SOME INTERMEDIATE STEPS
FT                   FOR THE SYNTHESIS OF A POLYKETIDE MOLECULE WHICH MAY BE
FT                   INVOLVED IN SECONDARY METABOLISM"
FT                   /note="Rv1661, (MTCY06H11.26), len: 2126 aa. Probable pks7,
FT                   polyketide synthase, similar to many e.g. ERY2_SACER|Q03132
FT                   erythronolide synthase, modules 3 and 4 (3567 aa), FASTA
FT                   scores: E(): 0, (48.8% identity in 2131 aa overlap); also
FT                   similar to Mycobacterium tuberculosis pks12. Contains
FT                   PS00606 Beta-ketoacyl synthases active site, PS00012
FT                   Phosphopantetheine attachment site."
FT                   /db_xref="GOA:P94996"
FT                   /db_xref="HSSP:1PQW"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:P94996"
FT                   /protein_id="CAB06632.1"
FT                   /translation="MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCR
FT                   YPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVA
FT                   GFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYG
FT                   GQGRVPGDLERYGLRGSTLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRL
FT                   GECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARL
FT                   ADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG
FT                   HGTGTTLGDPIEAQAILATYGQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRH
FT                   GVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEE
FT                   APAVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNT
FT                   RSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGM
FT                   GAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVS
FT                   LAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVS
FT                   LACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVD
FT                   YASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQ
FT                   FERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGR
FT                   FWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLV
FT                   GAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDE
FT                   VGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQ
FT                   GVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVF
FT                   ADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGVCLHASGAARVRVR
FT                   LAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGLLEMIWTPVPLEG
FT                   GDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAV
FT                   GPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVR
FT                   RGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVELATGQVRVAVG
FT                   AVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVV
FT                   DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSL
FT                   ARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLA
FT                   GEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSE
FT                   VVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVV
FT                   VTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDV
FT                   ADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHEL
FT                   TEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQA
FT                   SAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAA
FT                   LPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR
FT                   SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRL
FT                   VTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTEDDDIAA
FT                   ATESQLFAILDEELGS"
FT   misc_feature    144635..144685
FT                   /note="PS00606 Beta-ketoacyl synthases active site"
FT   misc_feature    146105..146137
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   misc_feature    150062..150109
FT                   /note="PS00012 Phosphopantetheine attachment site"
FT   CDS             150447..155255
FT                   /transl_table=11
FT                   /gene="pks8"
FT                   /locus_tag="Rv1662"
FT                   /product="Probable polyketide synthase pks8"
FT                   /function="POTENTIALLY INVOLVED IN SOME INTERMEDIATE STEPS
FT                   FOR THE SYNTHESIS OF A POLYKETIDE MOLECULE WHICH MAY BE
FT                   INVOLVED IN SECONDARY METABOLISM"
FT                   /note="Rv1662, (MTCY275.01-MTCY06H11.27), len: 1602 aa.
FT                   Probable pks8, polyketide synthase, similar to many
FT                   polyketide synthases e.g. ERY2_SACER|Q03132 erythronolide
FT                   synthase, modules 3 and 4 from Saccharopolyspora erythraea
FT                   (Streptomyces erythraeus) (3567 aa), FASTA scores: opt:
FT                   3319, E(): 0, (45.8% identity in 1619 aa overlap). Also
FT                   similar to other Mycobacterium tuberculosis probable
FT                   polyketide synthases e.g. pks7 and pks12. Contains PS00606
FT                   Beta-ketoacyl synthases active site and PS01162 Quinone
FT                   oxidoreductase/zeta-crystallin signature. Note that the
FT                   similarity extends into the downstream ORF Rv1663
FT                   (MTCY275.02), and this could be accounted for by a
FT                   frameshift, although the sequence has been checked and no
FT                   discrepancy was found."
FT                   /db_xref="GOA:O65933"
FT                   /db_xref="HSSP:1PQW"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O65933"
FT                   /protein_id="CAB09098.1"
FT                   /translation="MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRY
FT                   PGGVDSPETLWELVAQGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGD
FT                   FDAGFFGIGPSEALAMDPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGG
FT                   QLSGELEGYGLTGSTLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGEC
FT                   DLALAGGVTVMATPAAFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDA
FT                   RRLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGT
FT                   GTMLGDPIEAQALLATYGQDRVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMP
FT                   KTLHVDVPTPHVDWSVGAVSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVV
FT                   ESVVPEVASPTAASAVPWVLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRA
FT                   MFEHRAVVVGADRGALLAGLAALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGA
FT                   QLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQPALFAIEVALAT
FT                   LLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAA
FT                   SEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSL
FT                   LMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQ
FT                   LLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSVLGAVATLFTAG
FT                   AQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQ
FT                   PDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVT
FT                   PLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLS
FT                   VWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSG
FT                   FGIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVEL
FT                   ADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVV
FT                   WELESFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSVGQDATNLAGAAVWGL
FT                   VRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPD
FT                   TNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAE
FT                   LGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVP
FT                   VVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLH
FT                   TMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMG
FT                   KTEFGTPRSLPRTILGWPTGLST"
FT   misc_feature    151026..151076
FT                   /note="PS00606 Beta-ketoacyl synthases active site"
FT   misc_feature    154887..154940
FT                   /note="PS01162 Quinone oxidoreductase / zeta-crystallin
FT                   signature"
FT   CDS             155255..156763
FT                   /transl_table=11
FT                   /gene="pks17"
FT                   /locus_tag="Rv1663"
FT                   /product="Probable polyketide synthase pks17"
FT                   /function="POTENTIALLY INVOLVED IN SOME INTERMEDIATE STEPS
FT                   FOR THE SYNTHESIS OF A POLYKETIDE MOLECULE WHICH MAY BE
FT                   INVOLVED IN SECONDARY METABOLISM"
FT                   /note="Rv1663, (MTCY275.02), len: 502 aa. Probable pks17,
FT                   polyketide synthase, similar to other polyketide synthases
FT                   e g. ERY2_SACER|Q03132 erythronolide synthase, modules 3
FT                   and 4 (3567 aa) from Saccharopolyspora erythraea
FT                   (Streptomyces erythraeus), FASTA scores: opt: 1207, E(): 0,
FT                   (43.9% identity in 531 aa overlap). Also similar to other
FT                   Mycobacterium tuberculosis probable polyketide synthases
FT                   e.g. pks7 and pks1. Note that the similarity extends into
FT                   the upstream ORF Rv1662 (MTCY275.01) and this could be
FT                   accounted for by a frameshift, although the sequence has
FT                   been checked and no discrepancy was found. Contains PS00012
FT                   Phosphopantetheine attachment site."
FT                   /db_xref="GOA:O06585"
FT                   /db_xref="HSSP:2AF8"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O06585"
FT                   /protein_id="CAB09099.1"
FT                   /translation="MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLS
FT                   QARHVGKVVLTMPDAWAAGTVLITGGTGMAGSAVARHLVSRYGVRQVVLASRAGEHTES
FT                   VAALVDELGSAGARVQVVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGLTPE
FT                   RVDKVLRAKVDGAWNLHELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAY
FT                   RRSRGLAALSVAWGLWEQASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADR
FT                   PVVVAARLDRAALAGAELPALFSQLVAGPIRRIIDGADEVSGSGLASRLHGLTPEQRHR
FT                   ELTELVCSNAAIVLGHSGTEIDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFD
FT                   YPTAAELAEHLDIQLANAPAVTVDQPNPSTRFNEVTRELQALLDQPNWNPDDKTRLIKR
FT                   LQAILTDCTAPPASSGPSTTHDDEDITTATESQLFAILDDELGP"
FT   misc_feature    156359..156406
FT                   /note="PS00012 Phosphopantetheine attachment site"
FT   CDS             156769..159822
FT                   /transl_table=11
FT                   /gene="pks9"
FT                   /locus_tag="Rv1664"
FT                   /product="Probable polyketide synthase pks9"
FT                   /function="POTENTIALLY INVOLVED IN SOME INTERMEDIATE STEPS
FT                   FOR THE SYNTHESIS OF A POLYKETIDE MOLECULE WHICH MAY BE
FT                   INVOLVED IN SECONDARY METABOLISM"
FT                   /note="Rv1664, (MTCY275.03), len: 1017 aa. Probable pks9,
FT                   polyketide synthase, similar to OL56_STRAT|Q07017
FT                   oleandomycin polyketide synthase, modules 5 and 6 from
FT                   Streptomyces antibioticus (3519 aa), FASTA scores: opt:
FT                   1767, E(): 0, (41.6% identity in 919 aa overlap). Similar
FT                   to other Mycobacterium tuberculosis probable polyketide
FT                   synthases e.g. pks6, pks8, etc. Contains PS00012
FT                   Phosphopantetheine attachment site."
FT                   /db_xref="GOA:O06586"
FT                   /db_xref="HSSP:1MLA"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="UniProtKB/TrEMBL:O06586"
FT                   /protein_id="CAB09100.1"
FT                   /translation="MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFD
FT                   ADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLT
FT                   LAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEA
FT                   PLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAA
FT                   LDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHG
FT                   TGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVI
FT                   PPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQS
FT                   PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVST
FT                   RSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGM
FT                   GRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVAL
FT                   AALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAV
FT                   AASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFH
FT                   SVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDG
FT                   VGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFA
FT                   GLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVELVC
FT                   FHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPT
FT                   ASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGR
FT                   TVSDEVIDSLSPEALIGLALDEDENDIR"
FT   misc_feature    159448..159495
FT                   /note="PS00012 Phosphopantetheine attachment site"
FT   CDS             159969..161030
FT                   /transl_table=11
FT                   /gene="pks11"
FT                   /locus_tag="Rv1665"
FT                   /product="Possible chalcone synthase pks11"
FT                   /function="Possibly involved in the biosynthesis of
FT                   Secondary Metabolites [CATALYTIC ACTIVITY: 3 Malonyl-CoA +
FT                   4-Coumaroyl-CoA = 4 CoA + Naringenin chalcone + 3 CO2]"
FT                   /EC_number="2.3.1.74"
FT                   /note="Rv1665, (MTCY275.04-MTV047.01), len 353 aa. Possible
FT                   pks11, chalcone synthase (EC 2.3.1.74), some similarity to
FT                   BCSA_BACSU|P54157 putative chalcone synthase from Bacillus
FT                   subtilis (365 aa), FASTA scores: opt: 615, E(): 6.2e-32,
FT                   (33.4% identity in 308 aa overlap); and to many plant
FT                   chalcone synthases e.g. CHS_VIGUN|P51089 chalcone synthase
FT                   (EC 2.3.1.74) (388 aa), FASTA scores: opt: 391, E():
FT                   7.8e-18, (27.2% identity in 349 aa overlap). Highly similar
FT                   to upstream ORF Rv1660|MTCY06H11.25 pks10 (72.7% identity
FT                   in 308 aa overlap); and Rv1372 pks18."
FT                   /db_xref="GOA:O06587"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="UniProtKB/TrEMBL:O06587"
FT                   /protein_id="CAB09101.1"
FT                   /translation="MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAA
FT                   KVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATA
FT                   TVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLV
FT                   SVELCSLTYPAVKPTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYP
FT                   DSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGP
FT                   KVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEKRPPSGSAGLMLAMG
FT                   PGFCTELVLLRWR"
FT   CDS             complement(161013..162305)
FT                   /transl_table=11
FT                   /gene="cyp139"
FT                   /locus_tag="Rv1666c"
FT                   /product="Probable cytochrome P450 139 CYP139"
FT                   /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE
FT                   MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY
FT                   UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND
FT                   XENOBIOTICS."
FT                   /EC_number="1.14.-.-"
FT                   /note="Rv1666c, (MT1706, MTV047.02c), len: 430 aa. Probable
FT                   cyp139, cytochrome P450 (EC 1.14.-.-), similar to many e.g.
FT                   U38537|APU38537_7 from Anabaena sp. (459 aa), FASTA scores:
FT                   opt: 516, E(): 1.7e-26, (25.8% identity in 418 aa overlap).
FT                   Contains PS00086 Cytochrome P450 cysteine heme-iron ligand
FT                   signature. BELONGS TO THE CYTOCHROME P450 FAMILY."
FT                   /db_xref="GOA:P63719"
FT                   /db_xref="HSSP:1JPZ"
FT                   /db_xref="InterPro:IPR002403"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63719"
FT                   /protein_id="CAB09102.1"
FT                   /translation="MRYPLGEALLALYRWRGPLINAGVGGHGYTYLLGAEANRFVFANA
FT                   DAFSWSQTFESLVPVDGPTALIVSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNIDTV
FT                   IDGWQPGQRLDIYQELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTRRPPQVMR
FT                   LQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSEEGTTLSDN
FT                   EIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSAL
FT                   TYLNGVVHETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPT
FT                   EFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPA
FT                   QRTHRIRAANFAALRPWPGLTVEIRKSAPAQ"
FT   misc_feature    complement(161184..161213)
FT                   /note="PS00086 Cytochrome P450 cysteine heme-iron ligand
FT                   signature"
FT   CDS             complement(162320..162973)
FT                   /transl_table=11
FT                   /locus_tag="Rv1667c"
FT                   /product="PROBABLE SECOND PART OF MACROLIDE-TRANSPORT
FT                   ATP-BINDING PROTEIN ABC TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT                   MACROLIDE ACROSS THE MEMBRANE (EXPORT). MACROLIDE
FT                   ANTIBIOTICS RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE
FT                   FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM."
FT                   /note="Rv1667c, (MTV047.03c), len: 217 aa. Probable second
FT                   part of macrolide-transport ATP-binding protein ABC
FT                   transporter (see citation below), with similarity to
FT                   C-terminal end of putative ABC transporters/ATP binding
FT                   proteins, e.g. Z99108|BSUB0005_6 ABC transporter
FT                   (ATP-binding protein) homolog yfmR from Bacillus subtilis
FT                   (629 aa), FASTA scores: opt: 411, E(): 6.9e-17, (37.8%
FT                   identity in 217 aa overlap); etc. Similarity to other NBD
FT                   components of ABC transporters suggests that Rv1667c and
FT                   Rv1668c should be contiguous. However, sequence has been
FT                   checked and no errors found, also same sequence in M.
FT                   tuberculosis CSU93 and Mycobacterium bovis."
FT                   /db_xref="GOA:O53915"
FT                   /db_xref="InterPro:IPR003439"
FT                   /db_xref="UniProtKB/TrEMBL:O53915"
FT                   /protein_id="CAA17598.1"
FT                   /translation="MLGRLRGGYQVEGREVTPTQLLERLGFRRDQLSARVDDLSGGQRR
FT                   RLQLMLTLLSEPNVLLLDEPTNDVDTEMLTATEDLLDSWAGTLIVVSHDRYLLERVTDQ
FT                   QYAILDDRLRHLPGGIDEYLQLAARVSAPAPAERPAPPAMSGAQRRATEKELAAVDRQL
FT                   ARLADRVAAKHTELAEHDQSDHVGITRLTQQLRVLQDHVAAMENRWLELSEMLE"
FT   CDS             complement(162967..164085)
FT                   /transl_table=11
FT                   /locus_tag="Rv1668c"
FT                   /product="PROBABLE FIRST PART OF MACROLIDE-TRANSPORT
FT                   ATP-BINDING PROTEIN ABC TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT                   MACROLIDE ACROSS THE MEMBRANE (EXPORT). MACROLIDE
FT                   ANTIBIOTICS RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE
FT                   FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM."
FT                   /note="Rv1668c, (MTV047.04c), len: 372 aa. Probable first
FT                   part of macrolide-transport ATP-binding protein ABC
FT                   transporter (see citation below), similar to many
FT                   ATP-binding proteins ABC transporter e.g.
FT                   X80735|SEABCT_1|Q54072 Saccharopolyspora erythraea ertX
FT                   gene (481 aa), FASTA scores: opt: 938, E(): 0, (45.6%
FT                   identity in 353 aa overlap); etc. Similarity to other NBD
FT                   components of ABC transporters suggests that Rv1667c and
FT                   Rv1668c should be contiguous. However, sequence has been
FT                   checked and no error found, also same sequence in
FT                   Mycobacterium tuberculosis CSU93 and Mycobacterium bovis.
FT                   Contains PS00211 ABC transporters family signature and two
FT                   times PS00017 ATP/GTP-binding site motif A. BELONGS TO THE
FT                   ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)."
FT                   /db_xref="GOA:O53916"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="UniProtKB/TrEMBL:O53916"
FT                   /protein_id="CAA17599.1"
FT                   /translation="MAHLLGAEAVHLAYPTQVVFEAVTLGVNDGARIGIVGRNGDGKSS
FT                   LLGLLTGQLRPDSGRVTRRSGLRVNALSQTDTLDPNRTVGWTLIGDQPEHQWAGNPRIR
FT                   DVVAGLVSDIAWDTPVSTLSGGQRRRVQLASLLVGEWDVIALDEPTNHLDIQGITWLAD
FT                   HLRRRWARNTGGLLVVTHDRWFLDEVATTTWEVHDGIVEPFEGGYAAYVLQRVERDRLT
FT                   AAAEAKRQNLLRKELAWLRRGAPARTCKPKFRIEAANQLIADVPPPRNTVELAKLAAAR
FT                   LGKDVVDLLGVSVSYQPSGGRPVLRDIEWRIGPGERIGIVGANGAGKSTLLGLIAGTVQ
FT                   PGVGRVKPSGWQCSISTGTIWHRLPTTGSPMC"
FT   misc_feature    complement(163099..163122)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   misc_feature    complement(163675..163719)
FT                   /note="PS00211 ABC transporters family signature"
FT   misc_feature    complement(163954..163977)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             164468..164830
FT                   /transl_table=11
FT                   /locus_tag="Rv1669"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1669, (MTV047.04B), len: 120 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O86371"
FT                   /protein_id="CAA17609.1"
FT                   /translation="MSRRPGYSNGRAGASRQAARGGSAGASSVAFSSQPNCGLTESVLG
FT                   HQVTGICLGTIHLDAMQWPWSSAYRLEPAVATTLIGISAWWANGSVKQYAGDLTDRVAT
FT                   MTVCRRTPAPRVHYRQ"
FT   CDS             164863..165210
FT                   /transl_table=11
FT                   /locus_tag="Rv1670"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1670, (MTV047.05), len: 115 aa. Conserved
FT                   hypothetical protein, highly similar to D90908|D90908_87
FT                   Hypothetical protein of Synechocystis sp. PCC6803 complete
FT                   (94 aa), FASTA scores opt: 378, E(): 3.5e-2, (55.2%
FT                   identity in 96 aa overlap); also shows some similarity to
FT                   Mycobacterium tuberculosis hypothetical proteins e.g.
FT                   C-terminal region of O53404|Rv1056 (254 aa), and
FT                   P96817|Rv0140 (126 aa)."
FT                   /db_xref="InterPro:IPR007361"
FT                   /db_xref="UniProtKB/TrEMBL:O53917"
FT                   /protein_id="CAA17600.1"
FT                   /translation="MIRAVWNGTVLAEAPRTVRVEGNHYFPPESLHREHLIESPTTSIC
FT                   PWKGLAHYYNVVVDGPYGPVNPDAAWYYRRPSPLARRIKNHVAFWHGVTVEGESESRHG
FT                   LARRVVAWLGK"
FT   CDS             165218..165610
FT                   /transl_table=11
FT                   /locus_tag="Rv1671"
FT                   /product="PROBABLE MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1671, (MTV047.06), len: 130 aa. Probable membrane
FT                   protein. Weak similarity to mercuric transport proteins."
FT                   /db_xref="UniProtKB/TrEMBL:O53918"
FT                   /protein_id="CAA17601.1"
FT                   /translation="MPTVGPADHAAGLDRRATPDQLPIWRIGIISGLVGMLCCVGPTIL
FT                   ALVGIISAATAFAWANDLYDNYAWWFRVSGLAVLAILVWWALRHRNRCSVNAIRRLRWR
FT                   LMAVLAIAVGTYGVLSAVTTWFGTFV"
FT   CDS             complement(165619..166950)
FT                   /transl_table=11
FT                   /locus_tag="Rv1672c"
FT                   /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT
FT                   PROTEIN"
FT                   /function="THOUGHT TO BE INVOLVED IN TRANSPORT ACROSS THE
FT                   MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF
FT                   UNDETERMINATED SUBSTRATE ACROSS THE MEMBRANE."
FT                   /note="Rv1672c, (MTV047.07c), len: 443 aa. Probable
FT                   conserved integral membrane transport protein, major
FT                   facilitator superfamily, similar to several phthalate
FT                   transporters or tartrate transporters e.g.
FT                   U25634|AVU25634_2 Agrobacterium vitis plasmid pTrAB (433
FT                   aa), FASTA scores: opt: 914, E(): 0, (37.1% identity in 426
FT                   aa overlap); etc."
FT                   /db_xref="InterPro:IPR011701"
FT                   /db_xref="UniProtKB/TrEMBL:O53919"
FT                   /protein_id="CAA17602.1"
FT                   /translation="MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVAALAM
FT                   NADLRLSATAYGTAAGVFFLGYVLFQVPANAALARFGAGRTLTAVVLAWGVCSAATALV
FT                   TSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPCAQRARAVATFLLAIPVANTVGLPLS
FT                   GLIVGHVHMAGLPGWRAMFVIEALPALLLAPLLRRLLPDNPQRASWLTPEERAELSARL
FT                   TEDTPAPTGRSSGAGWDLVLFAVVYGGLYFALYALQFFLPQLVASLAHGTATLTAATLA
FT                   ALPYGVAALAMLAWSHRSIDRSGAQAGHITLPTTAAGSAALGAALSPMSPIVTLSWLTI
FT                   AVAGILAAMPAFWSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATGTYHL
FT                   ALLTVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV"
FT   CDS             complement(167043..167975)
FT                   /transl_table=11
FT                   /locus_tag="Rv1673c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1673c, (MTV047.08c), len: 310 aa. Conserved
FT                   hypothetical protein, shows weak similarity to
FT                   P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor
FT                   (369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in
FT                   330 aa overlap)."
FT                   /db_xref="InterPro:IPR002931"
FT                   /db_xref="UniProtKB/TrEMBL:O53920"
FT                   /protein_id="CAA17603.1"
FT                   /translation="MTITDPAVSAHADATIGLFEITDHITIDSTQGAHTVEMWCPVIGD
FT                   GAFQRVLDVEVTSEDPYDLTREPEFGNLMLYSRLRLATAASWSIRYVVERRAIGHAPDP
FT                   ARARPLATAQLFSRALIPEAHVDVDERTRTLAQDVVGPETNPLEQARRIYDYVTGAMDY
FT                   DATKQSFLGSTEHALTCSVGNCNDIHALFVSLCRSVDIPARFVLGQALELPQPGAQDCE
FT                   VCGYHCWAEFFVAGLGWLPADASCATKYGTHGLFANLQANHIAWSIGRDILLAPPQRAG
FT                   RSLFFAGPYAEIDGETHPAQRQIRFTAMT"
FT   CDS             complement(168003..168659)
FT                   /transl_table=11
FT                   /locus_tag="Rv1674c"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv1674c, (MTV047.09c), len: 218 aa. Probable
FT                   transcriptional regulatory protein. Highly similar to
FT                   AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA
FT                   scores: opt: 662, E(): 0, (50.0% identity in 208 aa
FT                   overlap). Similar to Rv0324|Z96800|MTCY63.29 M.
FT                   tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E():
FT                   0, (45.3% identity in 214 aa overlap). N-terminus is
FT                   similar to transcriptional activators e.g.
FT                   MERR_STRLI|P30346 probable mercury resistance operon
FT                   regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,
FT                   (35.6% identity in 90 aa overlap). Contains PS00380
FT                   Rhodanese signature 1."
FT                   /db_xref="GOA:O53921"
FT                   /db_xref="HSSP:1E0C"
FT                   /db_xref="InterPro:IPR001845"
FT                   /db_xref="UniProtKB/TrEMBL:O53921"
FT                   /protein_id="CAA17604.1"
FT                   /translation="MSGAKKLIFEQFALVGQALSSGHRLELLDLLVQGERSVDALARAS
FT                   GLTFANASQHLLQLRRAGLVTSRRDGKRVIYALSDPQVWDVVRAVRAVAERNLASVGSL
FT                   VRQYYTDRDSLEPISRDELQARVAAGSVLVLDVRPAMEYAAGHLPGAVSIPLDELAERL
FT                   DELPSGIDIVACCRGPYCVYAYDALELLRPNGFSARRLDGGFSEWLAADLPVVRT"
FT   misc_feature    complement(168198..168233)
FT                   /note="PS00380 Rhodanese signature 1"
FT   CDS             complement(168984..169718)
FT                   /transl_table=11
FT                   /locus_tag="Rv1675c"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT                   /note="Rv1675c, (MTV047.10c), len: 244 aa. Probable
FT                   transcriptional regulatory protein, weak similarity to
FT                   D00496|LBATRP_7 trp operon from Lactobacillus casei (219
FT                   aa), FASTA scores: opt: 172, E(): 0.00011, (26.9% identity
FT                   in 186 aa overlap)."
FT                   /db_xref="GOA:O53922"
FT                   /db_xref="InterPro:IPR014710"
FT                   /db_xref="UniProtKB/TrEMBL:O53922"
FT                   /protein_id="CAA17605.1"
FT                   /translation="MADRSVRPLRHLVHAVTGGQPPSEAQVRQAAWIARCVGRGGSAPL
FT                   HRDDVSALAETLQVKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAVVNILHP
FT                   GDVDGDIPLLLEMPMVYTGRALTQATCLFLDRQAFERLLATHPAIARRWLSSVAQRVST
FT                   AQIRLMGMLGRPLPAQVAQLLLDEAIDARIELAQRTLAAMLGAQRPSINKILKEFERDR
FT                   LITVGYAVIEITDQHGLRARAQ"
FT   CDS             169790..170494
FT                   /transl_table=11
FT                   /locus_tag="Rv1676"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1676, (MTV047.11), len: 234 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="InterPro:IPR012335"
FT                   /db_xref="UniProtKB/TrEMBL:O53923"
FT                   /protein_id="CAA17606.1"
FT                   /translation="MACPEWEISRSKRTRKPVLRPRHSVSTLTNRFLAEFCHRYGIGVP
FT                   TRLARGATVPTRRLQDINDQPVDVPAATGRTHLQFRRFAACPICHLHLRSFANRHQEVA
FT                   DSGITEVVFFHSAADALRGYQSLLPFAVIADPDRVQYREFGVEKSLGAITHPRALWAAV
FT                   RGSAAMLHRNDPERAGVGFGDGTTHLGLPADFLLDADGTVAAVHYGRHADDQWSVDQLI
FT                   DINRSLGGKGTQ"
FT   CDS             170491..171039
FT                   /transl_table=11
FT                   /gene="dsbF"
FT                   /locus_tag="Rv1677"
FT                   /product="PROBABLE CONSERVED LIPOPROTEIN DSBF"
FT                   /function="UNKNOWN; possibly involved in thiol:disulfide
FT                   interchange."
FT                   /note="Rv1677, (MTV047.12), len: 182 aa. Probable dsbF,
FT                   conserved lipoprotein possibly involved in thiol:disulfide
FT                   interchange. Highly similar to C-terminus of
FT                   Z74024|MTCY274.09 mpt53 soluble secreted antigen precursor
FT                   from Mycobacterium tuberculosis (173 aa), FASTA scores:
FT                   opt: 482, E(): 3.6e-23, (52.8% identity in 142 aa overlap)
FT                   . Also some similarity to P52237|TIPB_PSEFL THIOL:DISULFIDE
FT                   INTERCHANGE PROTEIN TIPB PRECURSOR from Pseudomonas
FT                   fluorescens (178 aa), FASTA scores: opt: 190, E(): 4.4e-05,
FT                   (28.5% identity in 151 aa overlap); and P33926|DSBE_ECOLI
FT                   THIOL:DISULFIDE INTERCHANGE PROTEIN from Escherichia coli
FT                   (185 aa), FASTA scores: opt: 194, E(): 2.6e-05, (29.1%
FT                   identity in 175 aa overlap). Contains PS00013 Prokaryotic
FT                   membrane lipoprotein lipid attachment site and PS00194
FT                   Thioredoxin family active site."
FT                   /db_xref="GOA:O53924"
FT                   /db_xref="InterPro:IPR017937"
FT                   /db_xref="PDB:1ZZO"
FT                   /db_xref="UniProtKB/TrEMBL:O53924"
FT                   /protein_id="CAA17607.1"
FT                   /translation="MTHSRLIGALTVVAIIVTACGSQPKSQPAVAPTGDAAAATQVPAG
FT                   QTVPAQLQFSAKTLDGHDFHGESLLGKPAVLWFWAPWCPTCQGEAPVVGQVAASHPEVT
FT                   FVGVAGLDQVPAMQEFVNKYPVKTFTQLADTDGSVWANFGVTQQPAYAFVDPHGNVDVV
FT                   RGRMSQDELTRRVTALTSR"
FT   misc_feature    170518..170550
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   misc_feature    170713..170769
FT                   /note="PS00194 Thioredoxin family active site"
FT   CDS             171140..172042
FT                   /transl_table=11
FT                   /locus_tag="Rv1678"
FT                   /product="PROBABLE INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1678, (MTV047.13), len: 300 aa. Probable integral
FT                   membrane protein."
FT                   /db_xref="UniProtKB/TrEMBL:O53925"
FT                   /protein_id="CAA17608.1"
FT                   /translation="MARVRRGTELLLSPQSPPATGGLIVLTGLRLLAGLIWLYNVVWKV
FT                   PPDFGERGRRDLYHFTHLAVEHPVFTPFSWVIEHAVLPYFTAFGWGVLFAESALAVLLL
FT                   TGTAVRLAALIGIGQSVAIGLSVAESPGEWPWAYAMLLGIHVVLLFTCSTRYAAVDAVR
FT                   AAATGSAARTAAQRLLAGWGIVLGLIGLVAVWRGLGDDRPAYVGIRALEFSLGEYNLRG
FT                   ALALIAIALAMLAAAKRGWRTVALVAAVVAVAAAAAIYLQVGRTAVWLGGTNTTAAVFV
FT                   CAAVVSLATEFRIGRVEGA"
FT   CDS             172042..173163
FT                   /transl_table=11
FT                   /gene="fadE16"
FT                   /locus_tag="Rv1679"
FT                   /product="POSSIBLE ACYL-CoA DEHYDROGENASE FADE16"
FT                   /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION."
FT                   /EC_number="1.3.99.-"
FT                   /note="Rv1679, (MTV047.14, MTCI125.01), len: 373 aa.
FT                   Possible fadE16, acyl-CoA dehydrogenase (EC 1.3.99.-),
FT                   similar to acyl/butyryl-CoA dehydrogenases e.g.
FT                   NP_244665.1|NC_002570 acyl-CoA dehydrogenase from Bacillus
FT                   halodurans (380 aa); NP_000008.1|NM_000017 acyl-Coenzyme A
FT                   dehydrogenase from Homo sapiens (412 aa);
FT                   Z99113|BSUB0010_119 from Bacillus subtilis (380 aa), FASTA
FT                   scores: opt: 439, E(): 3.4e-20, (29.6% identity in 287 aa
FT                   overlap); etc. Weakly similar to many dehydrogenases and to
FT                   P31571|CAIA_ECOLI probable carnitine operon oxidoreductase
FT                   from Escherichia coli (380 aa), FASTA scores: opt: 109,
FT                   E(): 0.0066, (28.6% identity in 98 aa overlap)."
FT                   /db_xref="GOA:O53926"
FT                   /db_xref="InterPro:IPR006092"
FT                   /db_xref="UniProtKB/TrEMBL:O53926"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17610.1"
FT                   /translation="MATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVL
FT                   PREIGGMGSGPVEFTEVVAQLSAACGSTAMIYLMHMAAAVTVAASPPPGLPDLLADMAS
FT                   GKQLGTLAFSEPGSRSHFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGSADG
FT                   AAGDVDLYAVPADTPGLRVAGTFTGMGLRGNASAPMAVDIRIPDSYRLGEAGGGFGIMM
FT                   QTVLPWFNLGNAAVSLGLATAATGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTL
FT                   AAQKAYLEVAANSVSSPDDTTLTHVLGVKASVNDAALTITESAMRVCGGAAFSKHLPIE
FT                   RAFRDARAGSVMAPTADALYDFYGRAVTGLPLF"
FT   CDS             173172..173996
FT                   /transl_table=11
FT                   /locus_tag="Rv1680"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1680, (MTCI125.02), len: 274 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O33182"
FT                   /protein_id="CAB10937.1"
FT                   /translation="MSTEPLVVGAVAYTPNVVPIWEGIRGYFQDSESPDTQMDFVLYSN
FT                   YARLVDSLIAGHIDIAWNTNLAYVRTVLQTGGRCTPLAQRDTDVDYTTVFVAHAGSDLH
FT                   GAKDIAGKRLALGSADSAHAAILPLYYLRRAGIAESDLQVIRFDTDIGKHGDTGRSELD
FT                   AVDAVLAGEADVAAIGSSTWAAMGAAELMGESLTEVWRTDGYCHCMFTALDTLPAERYQ
FT                   PWLDRLLAMSWDDSEHRKILELEGLRRWVPPHLDGYKPLFEAVQEQGIDPRW"
FT   CDS             173993..174985
FT                   /transl_table=11
FT                   /gene="moeX"
FT                   /locus_tag="Rv1681"
FT                   /product="POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEX"
FT                   /function="INVOLVED IN MOLYBDOPTENUM COFACTOR BIOSYNTHESIS"
FT                   /note="Rv1681, (MTCI125.03), len: 330 aa. Possible moeX,
FT                   Molybdopterin biosynthesis protein, has weak similarity to
FT                   MOAA_ECOLI|P30745 molybdenum cofactor biosynthesis protein
FT                   (329 aa), FASTA scores: opt: 162, E(): 0.00081, (27.7%
FT                   identity in 224 aa overlap) and to Rv3109|MTCY164.19 MoaA
FT                   from Mycobacterium tuberculosis (28.5% identity in 165 aa
FT                   overlap)."
FT                   /db_xref="GOA:O33183"
FT                   /db_xref="InterPro:IPR007197"
FT                   /db_xref="UniProtKB/TrEMBL:O33183"
FT                   /protein_id="CAB10938.1"
FT                   /translation="MIIELMRRVVGLAQGATAEVAVYGDRDRDLAERWCANTGNTLVRA
FT                   DVDQTGVGTLVVRRGHPPDPASVLGPDRLPGVRLWLYTNFHCNLCCDYCCVSSSPSTPH
FT                   RELGAERIGRIVGEAARWGVRELFLTGGEPFLLPDIDTIIATCVKQLPTTVLTNGMVFK
FT                   GRGRRALESLPRGLALQISLDSATPELHDAHRGAGTWVKAVAGIRLALSLGFRVRVAAT
FT                   VASPAPGELTAFHDFLDGLGIAPGDQLVRPIALEGAASQGVALTRESLVPEVTVTADGV
FT                   YWHPVAATDERALVTRTVEPLTPALDMVSRLFAEQWTRAAEEAALFPCA"
FT   CDS             175146..176063
FT                   /transl_table=11
FT                   /locus_tag="Rv1682"
FT                   /product="Probable coiled-coil structural protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1682, (MTCI125.04), len: 305 aa. Probable
FT                   coiled-coil structural protein, weakly similar to many
FT                   paramyosins, kinesins and plectins e.g. MYSP_ONCVO|Q02171
FT                   paramyosin from onchocerca volvulus (879 aa), fasta scores:
FT                   opt: 180, E():2.6e-08, (24.4% identity in 234 aa overlap).
FT                   Also similar to Mycobacterium tuberculosis hypothetical
FT                   coiled-coil proteins (wag31 antigen 84) Rv2145c and
FT                   Rv2927c."
FT                   /db_xref="UniProtKB/TrEMBL:O33184"
FT                   /protein_id="CAB10939.1"
FT                   /translation="MLPQRPNCTKLFRPRRGVSERYRVTTAHNGSAPRFQRTRSGYDPV
FT                   AVNHYIAELVLRQQAQHCEIETLKAEIASLKDENAALKDTSPSAQAVTDRMAKMLRLAV
FT                   DEVFQMQSEARAEAATLVSAARDEAEAVRTQKREMLADMNARQRALESEHADVMRRARE
FT                   EAEQLVAQATAEVERMRVIDARRREKAEQELDAEIIRLRTDAQFQIDDQLQATQQECEK
FT                   RLGEAKIEADRRLHVADEQIEHGLSEARRTLEEISQRRVGILEQLARIHAQLENIPALL
FT                   ESARHSETEPLQSINGAVAELRAI"
FT   repeat_region   176203..176258
FT                   /note="56 bp direct repeat 1,
FT                   AGTCGGGTGACGATGCGGGCCGGTGTGGTCCGAGGAGGAGCCCGACAATTTAAGCT"
FT   repeat_region   176259..176314
FT                   /note="56 bp direct repeat 2,
FT                   AGTCGGGTGACGATGCGGGCCGGTGTGGTCCGAGGAGGAGCCCGACAATTTAAGCT"
FT   CDS             176337..179336
FT                   /transl_table=11
FT                   /locus_tag="Rv1683"
FT                   /product="Possible long-chain acyl-CoA synthase"
FT                   /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID
FT                   DEGRADATION."
FT                   /note="Rv1683, (MTCI125.05), len: 999 aa. Possible
FT                   long-chain acyl-CoA synthase. Equivalent to
FT                   Z95117|MLCB1351_21 possible long-chain acyl-CoA synthase
FT                   from Mycobacterium leprae (1002 aa) (85.6% identity in 1002
FT                   aa overlap). Weakly similar to FATP_MOUSE|Q60714 long-chain
FT                   fatty acid transport protein (646 aa), fasta scores: opt:
FT                   331, E(): 5e-08, (24.8% identity in 630 aa overlap). Also
FT                   similar to O35488|AF033031 Mouse VERY-LONG-CHAIN ACYL-CoA
FT                   SYNTHETASE (620 aa), fasta scores: opt: 435, E(): 2.2e-12,
FT                   (24.8% identity in 545 aa overlap). Weakly similar to
FT                   Mycobacterium tuberculosis protein MTCI364.18 (27.4%
FT                   identity in 583 aa overlap) . Contains PS00120 Lipases,
FT                   serine active site."
FT                   /db_xref="GOA:O33185"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="UniProtKB/TrEMBL:O33185"
FT                   /protein_id="CAB10940.1"
FT                   /translation="MVDLNFSMVTRPIERLVATAQNGLEVLRLGGLETGSVPSPSQIVE
FT                   SVPMYKLRRYFPPDNRPGQPPVGPPVLMVHPMMMSADMWDVTREDGAVGILHASGLDPW
FT                   VIDFGSPDEVEGGMRRNLADHIVALSEAVDTVKDATGHDVHFVGYSQGGMFCYQAAAYR
FT                   RSKDIASVVAFGSPVDTLAALPMGIPANMGAAVADFMADHVFNRLDIPSWMARMGFQMM
FT                   DPLKTAKARVDFVRQLHDREALLPREQQRRFLESEGWIAWSGPAISELLKQFIAHNRMM
FT                   TGGFAISGQMVTLTDITCPILAFVGEVDDIGQPASVRGIRRAAPNSEVYECLIRAGHFG
FT                   LVVGSRAAQQSWPTVADWVRWISGDGTKPENIHLMADQPAEHTDSGVAFSSRVAHGIGE
FT                   VSEAALALARGAADAVVAANRSVRTLAVETVRTLPRLARLGQLNDHTRISLGRIIDEQA
FT                   HDAPKGEFLLFDGRVHTYEAVNRRINNVVRGLIAVGVRQGDRVGVLMETRPSALVAIAA
FT                   LSRLGAVAVVMRPDTDLSASVRLGRVTEILTDPTNLDAARQLPGQVLVLGGGESRDLDL
FT                   PADALEQGQVIDMEKIDPDAVELPAWYRPNPGLARDLAFIAFSSADGDLVAKQITNYRW
FT                   AVSAFGTASTAALGRRDTVYCLTPLHHESALLVSLGGAVVGGTRIALSRGLRPDRFVAE
FT                   VRQYGVTVVSYTWAMLRDVVDDPAFVLHGNHPVRLFIGSGMPTGLWERVVEAFAPAHVV
FT                   EFFATTDGQAVLANVAGAKIGSKGRPLPGAGRVELGAYDAEHDLILENDRGFVQVAGVN
FT                   QVGVLLAQSRGPIDPTASVKRGVFAPADTWISTDYLFWRDDDGDYWLAGGRGSVVRTAR
FT                   GMVYTEPVTNALGLITGVDLAVTYGVLVRGRHVAVSAVTLLPGATITAADLTEAVASMP
FT                   VGLGPDIVHVVPQLTLSGTYRPTVSALRANGIPKAGRQAWYFNSGGNEYRRLTPAVRTE
FT                   LTGQHRRGNA"
FT   misc_feature    176766..176795
FT                   /note="PS00120 Lipases, serine active site"
FT   CDS             179329..179553
FT                   /transl_table=11
FT                   /locus_tag="Rv1684"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1684, (MTCI125.06), len: 74 aa. Conserved
FT                   hypothetical protein, similar to P75844|YCAR_ECOLI Protein
FT                   YCAR from Escherichia coli (60 aa), FASTA scores: opt: 108,
FT                   E(): 0.00022, (39.0% identity in 59 aa overlap)."
FT                   /db_xref="InterPro:IPR005651"
FT                   /db_xref="UniProtKB/TrEMBL:O33186"
FT                   /protein_id="CAB10941.1"
FT                   /translation="MLDEALLAILVCPADRGPLVLVEDGDIQVLYNPRLRRAYRIEDGI
FT                   PVLLVDEAREVDEDEHARLMARGRPAAPQ"
FT   CDS             complement(179519..180142)
FT                   /transl_table=11
FT                   /locus_tag="Rv1685c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1685c, (MTCI125.07c), len: 207 aa. Conserved
FT                   hypothetical protein, some similarity to other
FT                   Mycobacterium tuberculosis hypothetical regulatory proteins
FT                   e.g. Q10774|Rv1556|YF56_MYCTU (202 aa), FASTA scores: opt:
FT                   111, E(): 1.7e-05, (24.1% identity in 195 aa overlap); and
FT                   P95215|Rv0258c|MTCY06A4.02c (151 aa) FASTA scores: (32.9%
FT                   identity in 140 aa overlap); also similar to
FT                   Q9X8G9|SCE7.13C|AL049819 putative Streptomyces coelicolor
FT                   transcriptional regulator (204 aa), FASTA scores: opt: 480,
FT                   E(): 6.4e-25, (40.4% identity in 203 aa overlap)."
FT                   /db_xref="GOA:O33187"
FT                   /db_xref="InterPro:IPR012287"
FT                   /db_xref="UniProtKB/TrEMBL:O33187"
FT                   /protein_id="CAB10942.1"
FT                   /translation="MAAPDNSRRRPGRPAGSSDTRERILSSARELFAHNGIDRTSIRAV
FT                   AAKAGVDAALVHHYFGTKQQLFAAAIHIPIDPMVIIGPIREAPVEELGYKLPSLLLPIW
FT                   DSELGAGLIATLRSLISGSDVGLARSFLEEVVTVELGSRVDNPPGTGKIRTQFVASQLM
FT                   GVVMARYIVRIEPFASLPAEQIVQTIAPNLQRYLTGELPDDLAP"
FT   CDS             complement(180144..180824)
FT                   /transl_table=11
FT                   /locus_tag="Rv1686c"
FT                   /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN ABC
FT                   TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT                   UNDETERMINATED SUBSTRATE (POSSIBLY DRUG) ACROSS THE
FT                   MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE
FT                   SUBSTRATE ACROSS THE MEMBRANE."
FT                   /note="Rv1686c, (MTCI125.08c), len: 226 aa. Probable
FT                   conserved integral membrane protein ABC transporter (see
FT                   citation below), similar to AL049819|SCE7.05 putative
FT                   integral membrane protein from Streptomyces coelicolor (266
FT                   aa), FASTA sacores: opt: 661, E(): 0, (45.1% identity in
FT                   226 aa overlap); and Q53627|U43537 MEMBRANE PROTEIN
FT                   INVOLVED IN MITHRAMYCIN RESISTANCE from STREPTOMYCES
FT                   ARGILLACEUS (233 aa), FASTA scores: opt: 222, E(): 5.4e-10,
FT                   (28.7% identity in 216 aa overlap)."
FT                   /db_xref="GOA:O33188"
FT                   /db_xref="InterPro:IPR013525"
FT                   /db_xref="UniProtKB/TrEMBL:O33188"
FT                   /protein_id="CAB10943.1"
FT                   /translation="MILLVPILIITLMYFMFENVPHRPGTPSGFNTACLVLLGLFPLFV
FT                   MFVITAITMQRERASGTLERILTTPLRRLDLLAGYGTAFSIAAAAQATLACIVAFWFLG
FT                   FDTAGSPVWVFAIAIVNAVLGVGLGLLCSAFARTEFQAVQFIPLVMVPQLLLAGIIVPR
FT                   ALMPTWLEWISNVMPASYALEALQQVGAHPELTGIAVRDVVVVLSFAVASLCLAAVTLR
FT                   RRTS"
FT   CDS             complement(180896..181663)
FT                   /transl_table=11
FT                   /locus_tag="Rv1687c"
FT                   /product="PROBABLE CONSERVED ATP-BINDING PROTEIN ABC
FT                   TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT                   UNDETERMINATED SUBSTRATE (POSSIBLY DRUG) ACROSS THE
FT                   MEMBRANE. RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT
FT                   SYSTEM."
FT                   /note="Rv1687c, (MTCI125.09c), len: 255 aa. Probable
FT                   conserved ATP-binding protein ABC transporter (see citation
FT                   below), similar to many ABC-type transporters e.g.
FT                   P55476|NODI_RHISN nodulation ATP-binding protein I from
FT                   Rhizobium sp. (343 aa), FASTA scores: opt: 479, E():
FT                   3.7e-23, (34.6% identity in 243 aa overlap); etc. Also
FT                   similar to many other Mycobacterium tuberculosis ABC-type
FT                   transporters e.g. MTCY19H9.04 (34.5% identity in 238 aa
FT                   overlap). Contains PS00211 ABC transporters family
FT                   signature and PS00017 ATP/GTP-binding site motif A
FT                   (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN
FT                   FAMILY (ABC TRANSPORTERS). Also contains PS00039 DEAD-box
FT                   subfamily ATP-dependent helicases signature, though this
FT                   may be spurious."
FT                   /db_xref="GOA:O33189"
FT                   /db_xref="InterPro:IPR017871"
FT                   /db_xref="UniProtKB/TrEMBL:O33189"
FT                   /protein_id="CAB10944.1"
FT                   /translation="MMISSSDELLRDGADPAVIIDQLRVIRGKRLALQDVSVRVACGTI
FT                   TGLLGPSGSGKTTLIRCIVGSQIIASGSVSVLGQPAGSAELRHRVGYMPQDPTIYNDLR
FT                   VIDNIRYFAELCGVDRQAADEVIEAVDLRDHRTARCANLSGGQRARVSLACALVGRPDL
FT                   LVLDEPTIGLDPVLRVELWDRFTALARRGTTLLVSSHVMDEADRCGDLLLLRQGQLLAH
FT                   TTPHRLRKETGCTSLEEAFLSIVRRTTTVPAAG"
FT   misc_feature    complement(181037..181063)
FT                   /note="PS00039 DEAD-box subfamily ATP-dependent helicases
FT                   signature"
FT   misc_feature    complement(181193..181237)
FT                   /note="PS00211 ABC transporters family signature"
FT   misc_feature    complement(181493..181516)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             181722..182333
FT                   /transl_table=11
FT                   /gene="mpg"
FT                   /locus_tag="Rv1688"
FT                   /product="POSSIBLE 3-METHYLADENINE DNA GLYCOSYLASE MPG"
FT                   /function="THOUGHT TO BE INVOLVED IN BASE EXCISION REPAIR."
FT                   /EC_number="3.2.2.-"
FT                   /note="Rv1688, (MTCI125.10), len: 203 aa. Possible mpg,
FT                   3-methyladenine DNA glycosylase (EC 3.2.2.-) (see citation
FT                   below), similar to several eukaryotic 3-methylpurine DNA
FT                   glycosylases and 3-methyladenine DNA glycosylases e.g.
FT                   Q39147|X76169 3-METHYLADENINE GLYCOSYLASE from Arabidobsis
FT                   thaliana (254 aa), FASTA scores: opt: 297, E(): 8.3e-15,
FT                   (31.8% identity in 198 aa overlap) and P29372|3MG_HUMAN
FT                   dna-3-methyladenine glycosidase (298 aa), FASTA scores:
FT                   opt: 220, E(): 7.2e-05, (36.4% identity in 184 aa overlap).
FT                   BELONGS TO THE MPG FAMILY OF DNA GLYCOSYLASES."
FT                   /db_xref="GOA:P65412"
FT                   /db_xref="HSSP:1F6O"
FT                   /db_xref="InterPro:IPR003180"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65412"
FT                   /protein_id="CAB10945.1"
FT                   /translation="MNAEELAIDPVAAAHRLLGATIAGRGVRAMVVEVEAYGGVPDGPW
FT                   PDAAAHSYRGRNGRNDVMFGPPGRLYTYRSHGIHVCANVACGPDGTAAAVLLRAAAIED
FT                   GAELATSRRGQTVRAVALARGPGNLCAALGITMADNGIDLFDPSSPVRLRLNDTHRARS
FT                   GPRVGVSQAADRPWRLWLTGRPEVSAYRRSSRAPARGASD"
FT   CDS             182345..183619
FT                   /transl_table=11
FT                   /gene="tyrS"
FT                   /locus_tag="Rv1689"
FT                   /product="Probable Tyrosyl-tRNA synthase tyrS (TYRRS)"
FT                   /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC
FT                   ACTIVITY: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate
FT                   + L-tyrosyl-tRNA(Tyr)]"
FT                   /EC_number="6.1.1.1"
FT                   /note="Rv1689, (MTCI125.11), len: 424 aa. Probable tyrS,
FT                   Tyrosyl-tRNA synthase (EC 6.1.1.1), highly similar to many
FT                   e.g. SYY_ECOLI|P00951 Escherichia coli (EC 6.1.1.1) (423
FT                   aa), FASTA scores: opt: 1271, E(): 0, (47.3% identity in
FT                   419 aa overlap). Contains PS00178 Aminoacyl-transfer RNA
FT                   synthetases class-I signature. BELONGS TO CLASS-I
FT                   AMINOACYL-TRNA SYNTHETASE FAMILY."
FT                   /db_xref="GOA:P67611"
FT                   /db_xref="InterPro:IPR002307"
FT                   /db_xref="PDB:2JAN"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67611"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB10946.1"
FT                   /translation="MSGMILDELSWRGLIAQSTDLDTLAAEAQRGPMTVYAGFDPTAPS
FT                   LHAGHLVPLLTLRRFQRAGHRPIVLAGGATGMIGDPRDVGERSLNEADTVAEWTERIRG
FT                   QLERFVDFDDSPMGAIVENNLEWTGSLSAIEFLRDIGKHFSVNVMLARDTIRRRLAGEG
FT                   ISYTEFSYLLLQANDYVELHRRHGCTLQIGGADQWGNIIAGVRLVRQKLGATVHALTVP
FT                   LVTAADGTKFGKSTGGGSLWLDPQMTSPYAWYQYFVNTADADVIRYLRWFTFLSADELA
FT                   ELEQATAQRPQQRAAQRRLASELTVLVHGEAATAAVEHASRALFGRGELARLDEATLAA
FT                   ALRETTVAELKPGSPDGIVDLLVASGLSASKGAARRTIHEGGVSVNNIRVDNEEWVPQS
FT                   SDFLHGRWLVLRRGKRSIAGVERIG"
FT   misc_feature    182465..182497
FT                   /note="PS00178 Aminoacyl-transfer RNA synthetases class-I
FT                   signature"
FT   CDS             184270..184653
FT                   /transl_table=11
FT                   /gene="lprJ"
FT                   /locus_tag="Rv1690"
FT                   /product="PROBABLE LIPOPROTEIN LPRJ"
FT                   /function="UNKNOWN"
FT                   /note="Rv1690, (MTCI125.12), len: 127 aa. Probable lprJ,
FT                   lipoprotein; contains possible signal sequence and PS00013
FT                   Prokaryotic membrane lipoprotein lipid attachment site.
FT                   Weakly similar to other Mycobacterium tuberculosis
FT                   hypothetical proteins with conserved cysteines e.g.
FT                   Rv1804c, Rv1810, Rv3354, etc"
FT                   /db_xref="InterPro:IPR007969"
FT                   /db_xref="UniProtKB/TrEMBL:O33192"
FT                   /protein_id="CAB10947.1"
FT                   /translation="MTAHTHDGTRTWRTGRQATTLLALLAGVFGGAASCAAPIQADMMG
FT                   NAFLTALTNAGIAYDQPATTVALGRSVCPMVVAPGGTFESITSRMAEINGMSRDMASTF
FT                   TIVAIGTYCPAVIAPLMPNRLQA"
FT   misc_feature    184342..184374
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             184692..185444
FT                   /transl_table=11
FT                   /locus_tag="Rv1691"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1691, MTCI125.13, len: 250 aa. Conserved
FT                   hypothetical protein, similar to Q9S210|SCI51.30C|AL109848
FT                   Hypothetical protein from Streptomyces coelicolor (210 aa),
FT                   FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180
FT                   aa overlap)."
FT                   /db_xref="InterPro:IPR011717"
FT                   /db_xref="UniProtKB/TrEMBL:O33193"
FT                   /protein_id="CAB10948.1"
FT                   /translation="MVDDRQGRRGGRRPRSAAADNRPAFRDGPAIPPGIHARQLAPEIR
FT                   RELSTLDRATADAVACHLVAAGELIDDDPEAALRHARAARVRASRIAAVREAVGIAAYR
FT                   CGDWAQALAELRAARRMGSKSPLLALIADCERGLGRPQRAIELARGSEAVELSGDAADE
FT                   LRIVAAGARADLGQLEQALTVLSTPQLDPGRTGSTAARLFYAYAEILLALGRGDEALQW
FT                   FLRSAAADIDGVTDAEDRVDELGAREQK"
FT   CDS             185441..186502
FT                   /transl_table=11
FT                   /locus_tag="Rv1692"
FT                   /product="PROBABLE PHOSPHATASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM"
FT                   /note="Rv1692, (MTCI125.14), len: 353 aa. Probable
FT                   phosphatase (EC 3.1.-.-), some similarity to others e.g.
FT                   PNPP_SCHPO|Q00472 4-nitrophenylphosphatase (269 aa), FASTA
FT                   scores: opt: 214, E(): 1.3e-10, (29.5% identity in 241 aa
FT                   overlap); and to NAGD_ECOLI|P15302 nagd protein from
FT                   Escherichia coli (250 aa), FASTA scores: opt: 314, E():
FT                   9.8e-08, (28.2% identity in 245 aa overlap). Also similar
FT                   to AL109848|SCI51.28 hypothetical protein from Streptomyces
FT                   coelicolor (343 aa), FASTA scores: opt: 768, E(): 0, (44.8%
FT                   identity in 315 aa overlap)."
FT                   /db_xref="GOA:O33194"
FT                   /db_xref="InterPro:IPR006357"
FT                   /db_xref="UniProtKB/TrEMBL:O33194"
FT                   /protein_id="CAB10949.1"
FT                   /translation="MKSIAQEHDCLLIDLDGTVFCGRQPTGGAVQSLSQVRSRKLFVTN
FT                   NASRSADEVAAHLCELGFTATGEDVVTSAQSAAHLLAGQLAPGARVLIVGTEALANEVA
FT                   AVGLRPVRRFEDRPDAVVQGLSMTTGWSDLAEAALAIRAGALWVAANVDPTLPTERGLL
FT                   PGNGSMVAALRTATGMDPRVAGKPAPALMTEAVARGDFRAALVVGDRLDTDIEGANAAG
FT                   LPSLMVLTGVNSAWDAVYAEPVRRPTYIGHDLRSLHQDSKLLAVAPQPGWQIDVGGGAV
FT                   TVCANGDVDDLEFIDDGLSIVRAVASAVWEARAADLHQRPLRIEAGDERARAALQRWSL
FT                   MRSDHPVTSVGTQ"
FT   CDS             186499..186675
FT                   /transl_table=11
FT                   /locus_tag="Rv1693"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1693, (MTCI125.15), len: 58 aa. Conserved
FT                   hypothetical protein, shows some similarity to AL583921
FT                   hypothetical protein from Mycobacterium leprae (61 aa).
FT                   Probable coiled-coil from aa 30 to 58."
FT                   /db_xref="InterPro:IPR018483"
FT                   /db_xref="UniProtKB/TrEMBL:O33195"
FT                   /protein_id="CAB10950.1"
FT                   /translation="MTIDPDQIRAEIDALLASLPDPADAENGPSLAELEGIARRLSEAH
FT                   EVLLAALESAEKG"
FT   CDS             186683..187489
FT                   /transl_table=11
FT                   /gene="tlyA"
FT                   /locus_tag="Rv1694"
FT                   /product="CYTOTOXIN|HAEMOLYSIN HOMOLOGUE TLYA"
FT                   /function="HAS A CONTACT-DEPENDENT HAEMOLYTIC ACTIVITY;
FT                   POSSIBLY INVOLVED IN VIRULENCE (PORE FORMATION)."
FT                   /note="Rv1694, (MTCI125.16), len: 268 aa. tlyA,
FT                   cytotoxin/haemolysin homologue (see citations below),
FT                   almost identical to NP_301968.1|NC_002677
FT                   cytotoxin/haemolysin homologue TlyA from Mycobacterium
FT                   leprae (269 aa). TlyA homologues were also identified by
FT                   PCR in Mycobacterium avium, Mycobacterium bovis BCG, but
FT                   appeared absent in M. smegmatis, M. vaccae, M. kansasii, M.
FT                   chelonae and M. phlei (see Wren et al., 1998). Also highly
FT                   similar to CAB83047.1|AJ271681 putative haemolysin from
FT                   Mycobacterium ulcerans (281 aa); and similar to
FT                   HLYA_TREHY|Q06803 pore-forming haemolysin/cytotoxin
FT                   virulence determinant from Treponema hyodysenteriae (240
FT                   aa), FASTA scores: opt: 514, E():3e-30, (37.3% identity in
FT                   236 aa overlap)."
FT                   /db_xref="GOA:Q50760"
FT                   /db_xref="InterPro:IPR004538"
FT                   /db_xref="UniProtKB/TrEMBL:Q50760"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB10951.1"
FT                   /translation="MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATA
FT                   VSDTTALTVVTDSERAWVSRGAHKLVGALEAFAIAVAGRRCLDAGASTGGFTEVLLDRG
FT                   AAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLTPEAIGGRVDLVVADLSFISLATV
FT                   LPALVGCASRDADIVPLVKPQFEVGKGQVGPGGVVHDPQLRARSVLAVARRAQELGWHS
FT                   VGVKASPLPGPSGNVEYFLWLRTQTDRALSAKGLEDAVHRAISEGP"
FT   CDS             187489..188412
FT                   /transl_table=11
FT                   /gene="ppnK"
FT                   /locus_tag="Rv1695"
FT                   /product="Inorganic polyphosphate/ATP-NAD kinase ppnK
FT                   (Poly(P)/ATP NAD kinase)"
FT                   /function="Catalyzes the phosphorylation of NAD to NADP.
FT                   Utilizes ATP and other nucleoside triphosphates as well as
FT                   inorganic polyphosphate as a source of phosphorus
FT                   [CATALYTIC ACTIVITY: ATP + NAD+ = ADP + NADP+]."
FT                   /EC_number="2.7.1.23"
FT                   /note="Rv1695, (MTCI125.17), len: 307 aa. ppnK, inorganic
FT                   polyphosphate/ATP-NAD kinase (EC 2.7.1.23) (see citation
FT                   below), equivalent to Q49897|MLC1351.13C|Z95117|PPNK_MYCLE
FT                   INORGANIC POLYPHOSPHATE/ATP-NAD KINASE from Mycobacterium
FT                   leprae (311 aa) (87.9% identity in 305 aa overlap). Also
FT                   similar to many e.g. P37768|PPNK_ECOLI PROBABLE INORGANIC
FT                   POLYPHOSPHATE/ATP-NAD KINASE (292 aa), FASTA scores: opt:
FT                   384, E(): 1.7e-23, (33.5% identity in 233 aa overlap); etc.
FT                   BELONGS TO THE NAD KINASE FAMILY."
FT                   /db_xref="GOA:P0A5S6"
FT                   /db_xref="InterPro:IPR002504"
FT                   /db_xref="PDB:1U0R"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5S6"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB10952.1"
FT                   /translation="MTAHRSVLLVVHTGRDEATETARRVEKVLGDNKIALRVLSAEAVD
FT                   RGSLHLAPDDMRAMGVEIEVVDADQHAADGCELVLVLGGDGTFLRAAELARNASIPVLG
FT                   VNLGRIGFLAEAEAEAIDAVLEHVVAQDYRVEDRLTLDVVVRQGGRIVNRGWALNEVSL
FT                   EKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVP
FT                   NNAHALFGRPMVTSPEATIAIEIEADGHDALVFCDGRREMLIPAGSRLEVTRCVTSVKW
FT                   ARLDSAPFTDRLVRKFRLPVTGWRGK"
FT   CDS             188426..190189
FT                   /transl_table=11
FT                   /gene="recN"
FT                   /locus_tag="Rv1696"
FT                   /product="PROBABLE DNA REPAIR PROTEIN RECN (RECOMBINATION
FT                   PROTEIN N)"
FT                   /function="INVOLVED IN RECOMBINATIONAL REPAIR OF DAMAGED
FT                   DNA."
FT                   /note="Rv1696, (MTCI125.18), len: 587 aa. Probable recN,
FT                   DNA repair protein (see citation below), similar to many
FT                   e.g. RECN_ECOLI|P05824 dna repair protein recN (553 aa),
FT                   FASTA scores: opt: 508, E(): 1.9e-33, (31.5% identity in
FT                   587 aa overlap). Equivalent to Z95117|MLCB1351_12 recN from
FT                   Mycobacterium leprae (587 aa), FASTA scores: (76.1% identit
FT                   y in 589 aa overlap). Contains PS00017 ATP/GTP-binding site
FT                   motif A (P-loop)."
FT                   /db_xref="GOA:P0A5U6"
FT                   /db_xref="InterPro:IPR004604"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5U6"
FT                   /protein_id="CAB10953.1"
FT                   /translation="MLTELRIESLGAISVATAEFDRGFTVLTGETGTGKTMVVTGLHLL
FT                   GGARADATRVRSGADRAVVEGRFTTTDLDDATVAGLQAVLDSSGAERDEDGSVIALRSI
FT                   SRDGPSRAYLGGRGVPAKSLSGFTNELLTLHGQNDQLRLMRPDEQRGALDRFAAAGEAV
FT                   QRYRKLRDAWLTARRDLVDRRNRARELAQEADRLKFALNEIDTVDPQPGEDVALVADIA
FT                   RLSELDTLREAATTARATLCGTPDADAFDRGAVDSLGRARAALQSSDDAALRGLAEQVG
FT                   EALTVVVDAVAELGAYLDELPADASALDAKLARQAQLRTLTRKYAADIDGVLRWADEAR
FT                   ARLAQLDVSEEGLAALERRTGELAHELGQAAVDLSTIRRKAAKRLAKEVSAELSALAMA
FT                   DAEFTIGVTTELADHGDPVALALASGELARAGADGVDAVEFGFVAHRGMTVLPLAKSAS
FT                   GGELSRVMLSLEVVLATSRKQAAGTTMVFDEIDAGVGGWAAVQIGRRLARLARTHQVIV
FT                   VTHLPQVAAYADVHLMVQRTGRDGASGVRRLTSEDRVAELARMLAGLGDSDSGRAHARE
FT                   LLETAQNDELT"
FT   misc_feature    188510..188533
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             190285..191466
FT                   /transl_table=11
FT                   /locus_tag="Rv1697"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1697, (MTCI125.19), len: 393 aa. Conserved
FT                   hypothetical protein, highly similar to
FT                   Q49895|MLC1351.11C|U00021 Hypothetical protein of
FT                   Mycobacterium leprae from cosmid L247 (430 aa), FASTA
FT                   scores: opt: 2345, E(): 0, (90.6% identity in 393 aa
FT                   overlap)."
FT                   /db_xref="GOA:O33198"
FT                   /db_xref="UniProtKB/TrEMBL:O33198"
FT                   /protein_id="CAB10954.1"
FT                   /translation="MRMSALLSRNTSRPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLD
FT                   LDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPEIFKKVKDGA
FT                   KVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAHLEAFAGNTIEFIRSESPL
FT                   LIDGIGIPDVDVDLRRRHVVIVADEPSGPDDLKSLKPFIKEYQPVLVGVGTGADVLRKA
FT                   GYRPQLIVGDPDQISTEVLKCGAQVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATD
FT                   LALLLADHHGAALLVTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLY
FT                   RNHISGGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS"
FT   CDS             191488..192432
FT                   /transl_table=11
FT                   /locus_tag="Rv1698"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1698, (MTCI125.20), len: 314 aa. Conserved
FT                   hypothetical protein, possibly exported protein with
FT                   potential N-terminal signal sequence. Equivalent to
FT                   Q49894|MLC1351.10C|Z95117 Hypothetical protein from
FT                   Mycobacterium leprae (317 aa), FASTA scores: (77.0%
FT                   identity in 317 aa overlap). Probable coiled-coil from aa
FT                   31 to 67."
FT                   /db_xref="GOA:P64883"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64883"
FT                   /protein_id="CAB10955.1"
FT                   /translation="MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDLY
FT                   TQIDRLTDQRDALREKLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAVSK
FT                   IVGQAGGAVTATVSLTQEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGDLLG
FT                   IALLSNADPAAPTVEQAQRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALSTDAG
FT                   NQGVSVARFAAALAPRGSGTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDIDAEPG
FT                   RITVILALHDLINGGHVGHYGTGHGAMSVTVSQ"
FT   CDS             192572..194332
FT                   /transl_table=11
FT                   /gene="pyrG"
FT                   /locus_tag="Rv1699"
FT                   /product="Probable CTP synthase PyrG"
FT                   /function="PYRIMIDINE BIOSYNTHESIS (LAST STEP) [CATALYTIC
FT                   ACTIVITY : ATP + UTP + GLUTAMINE = ADP + ORTHOPHOSPHATE +
FT                   CTP (AMMONIA CAN REPLACE GLUTAMINE).]"
FT                   /EC_number="6.3.4.2"
FT                   /note="Rv1699, (MTCI125.21), len: 586 aa. Probable pyrG,
FT                   CTP synthase (EC 6.3.4.2) highly similar to many e.g.
FT                   PYRG_ECOLI|P08398 ctp synthase from Escherichia coli (544
FT                   aa), FASTA scores: opt: 1786, E():0, (51.8% identity in 548
FT                   aa overlap). Contains PS00442 Glutamine amidotransferases
FT                   class-I active site."
FT                   /db_xref="GOA:P0A5U2"
FT                   /db_xref="InterPro:IPR000991"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5U2"
FT                   /protein_id="CAB10956.1"
FT                   /translation="MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQ
FT                   KLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRNLPGSANVTTGQVYST
FT                   VIAKERRGEYLGDTVQVIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGTVGDIESQ
FT                   PFLEAARQVRHYLGREDVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALIL
FT                   RCDRDVPEALKNKIALMCDVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFR
FT                   DVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSVAEALRAGGFKHRAKVEICWV
FT                   ASDGCETTSGAAAALGDVHGVLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCI
FT                   VIEAARSVGLTNANSAEFDPDTPDPVIATMPDQEEIVAGEADLGGTMRLGSYPAVLEPD
FT                   SVVAQAYQTTQVSERHRHRYEVNNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPF
FT                   VVGTQAHPELKSRPTRPHPLFVAFVGAAIDYKAGELLPVEIPEIPEHTPNGSSHRDGVG
FT                   QPLPEPASRG"
FT   misc_feature    193733..193768
FT                   /note="PS00442 Glutamine amidotransferases class-I active
FT                   site"
FT   CDS             194325..194948
FT                   /transl_table=11
FT                   /locus_tag="Rv1700"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1700, (MTCI125.22), len: 207 aa. Conserved
FT                   hypothetical protein, equivalent to
FT                   Q49891|MLC1351.08C|Z95117 Hypothetical protein from
FT                   Mycobacterium leprae (177 aa), FASTA scores: (66.7%
FT                   identity in 171 aa overlap); also similar to
FT                   Q9S225|SCI51.15C|AL109848 Hypothetical protein from
FT                   Streptomyces coelicolor (211 aa), FASTA scores: opt: 508,
FT                   E(): 1.2e-27, (43.1% identity in 197 aa overlap); similar
FT                   to P54570|ADPP_BACSU ADP-RIBOSE PYROPHOSPHATASE (EC
FT                   3.6.1.13) (185 aa), FASTA scores: opt: 313, E(): 1.1e-06,
FT                   (42.7% identity in 124 aa overlap)."
FT                   /db_xref="GOA:O33199"
FT                   /db_xref="InterPro:IPR000086"
FT                   /db_xref="PDB:1MK1"
FT                   /db_xref="UniProtKB/TrEMBL:O33199"
FT                   /protein_id="CAB10957.1"
FT                   /translation="MAEHDFETISSETLHTGAIFALRRDQVRMPGGGIVTREVVEHFGA
FT                   VAIVAMDDNGNIPMVYQYRHTYGRRLWELPAGLLDVAGEPPHLTAARELREEVGLQAST
FT                   WQVLVDLDTAPGFSDESVRVYLATGLREVGRPEAHHEEADMTMGWYPIAEAARRVLRGE
FT                   IVNSIAIAGVLAVHAVTTGFAQPRPLDTEWIDRPTAFAARRAER"
FT   CDS             194945..195880
FT                   /transl_table=11
FT                   /locus_tag="Rv1701"
FT                   /product="PROBABLE INTEGRASE/RECOMBINASE"
FT                   /function="SEQUENCE INTEGRATION/RECOMBINATION."
FT                   /note="Rv1701, (MTCI125.23), len: 311 aa. Probable
FT                   integrase/recombinase, similar to many e.g.
FT                   XERD_ECOLI|P21891 integrase/recombinase xerd (298 aa),
FT                   FASTA scores: opt: 583, E(): 0, (41.8% identity in 311 aa
FT                   overlap). Also similar to other Mycobacterium tuberculosis
FT                   integrase/recombinase proteins RV2894c|MTCY274.25c (43.1%
FT                   identity in 304 aa overlap); and Rv2646|MTCY441.16 phiRv2
FT                   integrase (31.1% identity in 161 aa overlap). Equivalent to
FT                   Z95117|MLCB1351_7 from Mycobacterium leprae (316 aa) (85.4%
FT                   identity in 316 aa overlap)."
FT                   /db_xref="GOA:P67636"
FT                   /db_xref="HSSP:1A0P"
FT                   /db_xref="InterPro:IPR011932"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67636"
FT                   /protein_id="CAB10958.1"
FT                   /translation="MKTLALQLQGYLDHLTIERGVAANTLSSYRRDLRRYSKHLEERGI
FT                   TDLAKVGEHDVSEFLVALRRGDPDSGTAALSAVSAARALIAVRGLHRFAAAEGLAELDV
FT                   ARAVRPPTPSRRLPKSLTIDEVLSLLEGAGGDKPSDGPLTLRNRAVLELLYSTGARISE
FT                   AVGLDLDDIDTHARSVLLRGKGGKQRLVPVGRPAVHALDAYLVRGRPDLARRGRGTAAI
FT                   FLNARGGRLSRQSAWQVLQDAAERAGITAGVSPHMLRHSFATHLLEGGADVRVVQELLG
FT                   HASVTTTQIYTLVTVHALREVWAGAHPRAR"
FT   CDS             complement(195954..197318)
FT                   /transl_table=11
FT                   /locus_tag="Rv1702c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN. THOUGHT TO BE REGULATED BY
FT                   Rv2720|LEXA."
FT                   /note="Rv1702c, (MTCI125.24c), len: 454 aa. Conserved
FT                   hypothetical ORF in REP13E12 degenerate repeat. Similar to
FT                   other hypothetical proteins inside REP13E12 elements (often
FT                   in two parts) e.g. Rv0094c|Q50655|MTCY251.13c (317 aa),
FT                   FASTA scores: opt: 1284, E(): 0, (59.7% identity in 315 aa
FT                   overlap); and Rv1128c, Rv1945, Rv1148c, etc."
FT                   /db_xref="InterPro:IPR003615"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64885"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB10959.1"
FT                   /translation="MYSSSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCEK
FT                   IRRRLPAAEHPFINKLADQTDQTELGGKLPFALAERLHISRGEASRRIHEAADLGPRRT
FT                   LTGQPLPPLLTATAAAQRAGHLGPAHVQVIRCFLHQLPHHVDLPTREKAEAELATLGGR
FT                   FRPDQLHKLATKLADCLNPDGNYNDTDRARRRSIILGNQGPDGMSAISGYLTPEARATV
FT                   DAVLAKLAAPGMANPADDTPCLAGTPSQAAIEADTRSAGQRHHDGLLAALRALLCSGEL
FT                   GQHNGLPAAIIVSTSLTELQSRAGHALTGGGTLLPMSDVIRLASHANHYLRIFDHGREL
FT                   ALYHTKRLASPGQRIVLYAKDRGCSFPNCDVPGYLTEVHHVTDFAQCQETDINELTQGC
FT                   GPHHQLATTGGWITRKRKDGTTEWLPPAHLDHGQPRTNSYFHPEKLLHDSDEDDP"
FT   repeat_region   195961..197332
FT                   /label=REP-6
FT                   /rpt_type=DIRECT
FT                   /note="REP-6, len: 1372 bp. REPI125, member of REP13E12
FT                   family."
FT   CDS             complement(197874..198464)
FT                   /transl_table=11
FT                   /locus_tag="Rv1703c"
FT                   /product="Probable catechol-o-methyltransferase"
FT                   /function="CATALYZES THE O-METHYLATION [CATALYTIC ACTIVITY:
FT                   S-ADENOSYL-L-METHIONINE + CATECHOL =
FT                   S-ADENOSYL-L-HOMOCYSTEINE + GUAIACOL]"
FT                   /EC_number="2.1.1.6"
FT                   /note="Rv1703c, (MTCI125.25c), len: 196 aa. Probable
FT                   catechol-o-methyltransferase (EC 2.1.1.6), most similar to
FT                   COMT_HUMAN|P21964 soluble form of mammalian catechol
FT                   o-methyltransferase (271 aa), FASTA scores: opt: 405, E():
FT                   7 .8e-29, (38.9% identity in 190 aa overlap). Also similar
FT                   to Mycobacterium tuberculosis hypothetical
FT                   methyltransferases Rv0187, Rv1220c."
FT                   /db_xref="GOA:O33202"
FT                   /db_xref="HSSP:1H1D"
FT                   /db_xref="InterPro:IPR002935"
FT                   /db_xref="UniProtKB/TrEMBL:O33202"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB10960.1"
FT                   /translation="MLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYL
FT                   GYGALRIARAAPEARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL
FT                   TEHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMR
FT                   RQQGMSWNTIEHKTHLEYQTLVPDLVLESEYLG"
FT   CDS             complement(198529..200199)
FT                   /transl_table=11
FT                   /gene="cycA"
FT                   /locus_tag="Rv1704c"
FT                   /product="PROBABLE D-SERINE/ALANINE/GLYCINE TRANSPORTER
FT                   PROTEIN CYCA"
FT                   /function="PERMEASE THAT IS INVOLVED IN THE TRANSPORT
FT                   ACROSS THE CYTOPLASMIC MEMBRANE OF D-ALANINE, D-SERINE AND
FT                   GLYCINE"
FT                   /note="Rv1704c, (MTCI125.26c), len: 556 aa. Probable cycA,
FT                   D-serine/D-alanine/glycine transporter, highly similar to
FT                   P39312|CYCA_ECOLI d-serine/d-alanine/glycine transporter
FT                   from Escherichia coli (470 aa), FASTA scores: opt: 1906,
FT                   E(): 0, (59.3% identity in 459 aa overlap); etc. Also
FT                   similar to other Mycobacterium tuberculosis amino-acid
FT                   permeases e.g. Rv2127, Rv0346c, etc. Contains PS00218 amino
FT                   acid permeases signature. BELONGS TO THE AMINO ACID
FT                   PERMEASE FAMILY (APC FAMILY)."
FT                   /db_xref="GOA:O33203"
FT                   /db_xref="InterPro:IPR004841"
FT                   /db_xref="UniProtKB/TrEMBL:O33203"
FT                   /protein_id="CAB10961.1"
FT                   /translation="MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSGR
FT                   TISLAGPAVMVVYGIIGFFVFFVLRAMGELLLSNLNYKSFVDFAADLRGPAAGFFVGWS
FT                   YWFAWVVTGIADLVAITGYARFWWPGLPIWVPALVTVALILAVNLFSVRHFGELEFWFA
FT                   LIKVAAIVCLIAVGAILVATNFVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIAFFA
FT                   YIGVELVGTAAAETADPRRTLPRAINAVPLRVAVFYIGALLAILAVVPWRQFASGESPF
FT                   VTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTGRMLFGLADEGHAPAAFHQLNRGG
FT                   VPAPALLLTAPLLLTSIPLLYAGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRH
FT                   PQRHTDSVYKMPGGVVMCWAVLVFFAFVIWTLTTETETATALAWFPLWFVLLAVGWLVT
FT                   QRRQSRRSFGFHCQVVGVRQQLGRGMARLAMKIHARPKLRSAVVVEPVSAGEPGARRSA
FT                   KSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR"
FT   misc_feature    complement(199960..200052)
FT                   /note="PS00218 Amino acid permeases signature"
FT   CDS             complement(200240..201397)
FT                   /transl_table=11
FT                   /gene="PPE22"
FT                   /locus_tag="Rv1705c"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1705c, (MTCI125.27c), len: 385 aa. Member of the
FT                   Mycobacterium tuberculosis PPE family of glycine-rich
FT                   proteins, similar to many e.g. YX23_MYCTU|Q10813
FT                   hypothetical 41.1 kDa protein cy274.2 3 (404 aa), fasta
FT                   scores: opt: 819, E(): 0, (46.2% identity in 413 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR000030"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q79FL6"
FT                   /protein_id="CAE55412.1"
FT                   /translation="MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVAAVGY
FT                   ERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAASQARAAAAAYETAFAAI
FT                   VPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQYAEMWAQDAMAMYGYAGSSATATK
FT                   VTPFAPPPNTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLPNTLLGLTSPLSSA
FT                   LTAAATPGWLEWFINWYLPISQLFYNTVGLPYFAIGIGNSLITSWRALGWIGPEAAEAA
FT                   AAAPAAVGAAVGGTGPVSAGLGNAATIGKLSLPPNWAGASPSLAPTVGSASAPLVSDIV
FT                   EQPEAGAAGNLLGGMPLAGSGTGTGGAGPRYGFRVTVMSRPPFAG"
FT   CDS             complement(201437..202621)
FT                   /transl_table=11
FT                   /gene="PPE23"
FT                   /locus_tag="Rv1706c"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1706c, (MTCI125.28c), len: 394 aa. Member of the
FT                   Mycobacterium tuberculosis PPE family of glycine-rich
FT                   proteins, similar to many e.g. YX23_MYCTU|Q10813
FT                   hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta
FT                   scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR000030"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q7D842"
FT                   /protein_id="CAE55413.1"
FT                   /translation="MTLDVPVNQGHVPPGSVACCLVGVTAVADGIAGHSLSNFGALPPE
FT                   INSGRMYSGPGSGPLMAAAAAWDGLAAELSSAATGYGAAISELTNMRWWSGPASDSMVA
FT                   AVLPFVGWLSTTATLAEQAAMQARAAAAAFEAAFAMTVPPPAIAANRTLLMTLVDTNWF
FT                   GQNTPAIATTESQYAEMWAQDAAAMYGYASAAAPATVLTPFAPPPQTTNATGLVGHATA
FT                   VAALRGQHSWAAAIPWSDIQKYWMMFLGALATAEGFIYDSGGLTLNALQFVGGMLWSTA
FT                   LAEAGAAEAAAGAGGAAGWSAWSQLGAGPVAASATLAAKIGPMSVPPGWSAPPATPQAQ
FT                   TVARSIPGIRSAAEAAETSVLLRGAPTPGRSRAAHMGRRYGRRLTVMADRPNVG"
FT   CDS             complement(203225..203392)
FT                   /transl_table=11
FT                   /locus_tag="Rv1706A"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1706A, len: 55 aa. Conserved hypothetical protein,
FT                   similar to part of several probable export proteins e.g.
FT                   Rv0783c|Z80226_28 from Mycobacterium tuberculosis (540 aa),
FT                   FASTA scores: opt: 125, E(): 0.011, (52.85% identity in 53
FT                   aa overlap). Size difference suggests possible gene
FT                   fragment."
FT                   /db_xref="UniProtKB/TrEMBL:Q79FL4"
FT                   /protein_id="CAE55414.1"
FT                   /translation="MGSLAAFKLGWLLSAMAPNVVLLTAFRVPQGLTMLTVFATGQAGQ
FT                   HRCRTFHVTP"
FT   CDS             203625..205085
FT                   /transl_table=11
FT                   /locus_tag="Rv1707"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF
FT                   SULFATE ACROSS THE MEMBRANE."
FT                   /note="Rv1707, (MTCI125.29), len: 486 aa. Probable
FT                   conserved transmembrane protein, possibly involved in
FT                   transport of sulfate, similar to several hypothetical
FT                   proteins belonging to the sulfate permease family e.g.
FT                   P40877|YCHM_ECOLI hypothetical 58.4 kDa protein in pth-prsa
FT                   intergenic region from Escherichia coli (550 aa), FASTA
FT                   scores: opt: 486, E(): 0, (33.1% identity in 492 aa
FT                   overlap). Also similar to many other Mycobacterium
FT                   tuberculosis membrane proteins e.g. Rv3273, Rv1739c. SEEMS
FT                   TO BELONG TO THE SULP FAMILY."
FT                   /db_xref="GOA:O33206"
FT                   /db_xref="InterPro:IPR011547"
FT                   /db_xref="UniProtKB/TrEMBL:O33206"
FT                   /protein_id="CAB10964.1"
FT                   /translation="MLQRIARELLSGVAVAIVALPLAIAFGITATGTSQGALIGLYGAI
FT                   FAGFFAAVFGGTPGQVTGPTGPITVVATATIAEHGLEGAFFAFILAGVFQILFGACRLG
FT                   SLIRYVPHPVISGFMGGIAILIIMTQLDQVRSSSLLVLVTVVLLLASGRFIKAIPPSLL
FT                   VLVLVSSVLPLAAPWLRDLRAGPVSINRTVDYIGEIPQAMPSFDFPQVANSTMLQVLLS
FT                   AVAIALLGSLDSLLTSLVMDNIRGTRHRSNKELIGQGIGNIAAGLFGGLSGAGATVRSV
FT                   VNVRNGGQTALSAATHSVVLFVFVAGLGAVVQYIPLAVLSGILILVAVGMFDWHAMRKA
FT                   HVSPRGDVIVMFTTMIITVVVDLTIAVMVGIALSLLVHRLRSRQRKAKVTQDDTGTYRI
FT                   DGPLSFLSVDGVFGSLRDGREDVSLDLQHVTYLDTSGARALLYFIDHSEKDGVAVSIKR
FT                   IPPRLESQLTALADNEQRDKLRTVLESA"
FT   CDS             205103..206059
FT                   /transl_table=11
FT                   /locus_tag="Rv1708"
FT                   /product="PUTATIVE INITIATION INHIBITOR PROTEIN"
FT                   /function="UNKNOWN; THOUGHT TO BE INVOLVED IN CELL
FT                   PROCESS."
FT                   /note="Rv1708, (MTCI125.30), len: 318 aa. Putative
FT                   initiation inhibitor protein, a soj-related protein
FT                   probably involved in cell process, highly similar to many
FT                   sporulation initiation inhibitor proteins soj e.g.
FT                   P37522|SOJ_BACSU Soj protein from Bacillus subtilis (253
FT                   aa), FASTA scores: opt: 745, E(): 0, (46.0% identity in 248
FT                   aa overlap), and more weakly to various repA/para/incC
FT                   proteins from various organisms e.g. Y4CK_RHISN|P55393
FT                   putative replication protein A from Rhizobium sp. (407 aa),
FT                   FASTA scores: opt: 205, E(): 4e-13, (29.0% identity in 252
FT                   aa overlap). Also similar to Mycobacterium tuberculosis
FT                   hyothetical proteins Rv3213c and Rv3918c."
FT                   /db_xref="GOA:O33207"
FT                   /db_xref="HSSP:1IHU"
FT                   /db_xref="InterPro:IPR002586"
FT                   /db_xref="UniProtKB/TrEMBL:O33207"
FT                   /protein_id="CAB10965.1"
FT                   /translation="MPAGLPGQASVAVRLSCDVPPDARHHEPRPGMTDHPDTGNGIGLT
FT                   GRPPRAIPDPAPRSSHGPAKVIAMCNQKGGVGKTTSTINLGAALGEYGRRVLLVDMDPQ
FT                   GALSAGLGVPHYELDKTIHNVLVEPRVSIDDVLIHSRVKNMDLVPSNIDLSAAEIQLVN
FT                   EVGREQTLARALYPVLDRYDYVLIDCQPSLGLLTVNGLACTDGVIIPTECEFFSLRGLA
FT                   LLTDTVDKVRDRLNPKLDISGILITRYDPRTVNSREVMARVVERFGDLVFDTVITRTVR
FT                   FPETSVAGEPITTWAPKSAGALAYRALARELIDRFGM"
FT   CDS             206056..206892
FT                   /transl_table=11
FT                   /locus_tag="Rv1709"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1709, (MTCI125.31), len: 278 aa. Conserved
FT                   hypothetical protein, similar to others e.g.
FT                   P35154|YPUG_BACSU from Bacillus subtilis (251 aa), FASTA
FT                   scores: opt: 271, E(): 8.2e-10, (27.0% identity in 248 aa
FT                   overlap); Q9S230|SCI51.10C|AL109848 from Streptomyces
FT                   coelicolor (264 aa), FASTA scores: opt: 855, E(): 0, (56.8%
FT                   identity in 257 aa overlap). Equivalent to
FT                   Q49888|MLC1351.05C|Z95117 from Mycobacterium leprae (268
FT                   aa), FASTA scores: (78.9% identity in 251 aa overlap)."
FT                   /db_xref="GOA:O33208"
FT                   /db_xref="InterPro:IPR003768"
FT                   /db_xref="UniProtKB/TrEMBL:O33208"
FT                   /protein_id="CAB10966.1"
FT                   /translation="MNGLQNSLANGGTAPENGYSAGFRVRLTNFEGPFDLLLQLIFAHQ
FT                   LDVTEVALHQVTDDFIAYTKAIGARLELEETTAFLVIAATLLDLKAARLLPAGQVDDEE
FT                   DLALLEVRDLLFARLLQYRAFKHVAEMFAELEATALRSYPRAVSLEDGFVGLLPEVMLG
FT                   VDAHRFAEIAAIALTPRPAPTVATEHLHELMVSVPEQAEHLLAMLKARGSGQWASFSEL
FT                   VADCTAPIEIVGRFLALLELYRTRAVAFEQSEPLGALQVSWTGDDAERSDEKERRL"
FT   repeat_region   206836..206888
FT                   /note="53 bp Mycobacterial Interspersed Repetitive Unit,
FT                   Class II"
FT   CDS             206889..207584
FT                   /transl_table=11
FT                   /locus_tag="Rv1710"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1710, (MTCI125.32), len: 231 aa. Conserved
FT                   hypothetical protein, similar to several hypothetical
FT                   proteins e.g. P35155|YPUH_BACSU from Bacillus subtilis (197
FT                   aa), FASTA scores: opt: 339, E(): 1.3e-09, (36.0% identity
FT                   in 186 aa overlap); Q9S231|SCI51.09C|AL109848 from
FT                   Streptomyces coelicolor (223 aa), FASTA scores: opt: 626,
FT                   E(): 0, (51.0% identity in 192 aa overlap). Equivalent to
FT                   O05669|MLC1351.04C|Z95117 Hypothetical protein from
FT                   Mycobacterium leprae (231 aa), FASTA scores: (77.9%
FT                   identity in 231 aa overlap)."
FT                   /db_xref="GOA:O33209"
FT                   /db_xref="InterPro:IPR011991"
FT                   /db_xref="PDB:2Z99"
FT                   /db_xref="UniProtKB/TrEMBL:O33209"
FT                   /protein_id="CAB10967.1"
FT                   /translation="MTEHMPEHDPSYGIPDIAEPAELDADELKRVLEALLLVIDTPVTA
FT                   DALAAATEQPVYRVAAKLQLMADELTGRDSGIDLRHTSEGWRMYTRARFAPYVEKLLLD
FT                   GARTKLTRAALETLAVVAYRQPVTRARVSAVRGVNVDAVMRTLLARGLITEVGTDADTG
FT                   AVTFATTELFLERLGLTSLSELPDIAPLLPDVDTIDDLSESLDSEPRFIKLTGELASEQ
FT                   TLSFDVDRD"
FT   CDS             207581..208345
FT                   /transl_table=11
FT                   /locus_tag="Rv1711"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1711, (MTCI125.33), len: 254 aa. Conserved
FT                   hypothetical protein, highly similar to a large family of
FT                   hypothetical proteins e.g. P37765|YCIL_ECOLI from
FT                   Escherichia coli (291 aa), FASTA scores: opt: 496, E():
FT                   1.1e-29, (41.6% identity in 250 aa overlap);
FT                   9S232|SCI51.08C|AL109848 PUTATIVE PSEUDOURIDINE SYNTHASE
FT                   from Streptomyces coelicolor (371 aa), FASTA scores: opt:
FT                   818, E(): 0, (53.1% identity in 245 aa overlap). Equivalent
FT                   to O05668|MLCB1351.03C|Z95117 Hypothetical protein from
FT                   Mycobacterium leprae (256 aa), (80.5% identity in 256 aa
FT                   overlap). Contains PS01149 Hypothetical yciL/yejD/yjbC
FT                   family signature."
FT                   /db_xref="GOA:P65842"
FT                   /db_xref="HSSP:1KSK"
FT                   /db_xref="InterPro:IPR002942"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65842"
FT                   /protein_id="CAB10968.1"
FT                   /translation="MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDGH
FT                   VVTELGTRVDPQVAVVRVDGARVVLDDSLVYLALNKPRGMHSTMSDDRGRPCIGDLIER
FT                   KVRGTKKLFHVGRLDADTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRGLGR
FT                   TLRAGIELDDGPAFVDDFAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEALVRT
FT                   DIGAVSLGKQRPGSVRALRSNEIGQLYQAVGL"
FT   misc_feature    207926..207976
FT                   /note="PS01149 Hypothetical yciL/yejD/yjbC family
FT                   signature"
FT   CDS             208342..209034
FT                   /transl_table=11
FT                   /gene="cmk"
FT                   /locus_tag="Rv1712"
FT                   /product="Probable Cytidylate kinase cmk (CMP kinase)
FT                   (Cytidine monophosphate kinase) (CK)"
FT                   /function="Catalyzes the transfer of a phosphate group from
FT                   ATP to either CMP or UMP to form CDP or UDP and ADP
FT                   [CATALYTIC ACTIVITY: ATP + CMP = ADP + CDP]."
FT                   /EC_number="2.7.4.14"
FT                   /note="Rv1712, (MTCI125.34), len: 230 aa. Probable cmk,
FT                   cytidylate kinase (EC 2.7.4.14), highly similar to many
FT                   e.g. KCY_ECOLI|P23863 cytidylate kinase from Escherichia
FT                   coli (227 aa), FASTA scores: opt: 534, E (): 0, (40.3%
FT                   identity in 221 aa overlap). Contains PS00017
FT                   ATP/GTP-binding site motif A (P-loop). Equivalent to
FT                   Z95117|MLCB1351_2 from Mycobacterium leprae (223 aa) (73.5%
FT                   identity in 226 aa overlap). BELONGS TO THE CYTIDYLATE
FT                   KINASE FAMILY, SUBFAMILY 1."
FT                   /db_xref="GOA:P63803"
FT                   /db_xref="HSSP:1CKE"
FT                   /db_xref="InterPro:IPR011994"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63803"
FT                   /protein_id="CAB10969.1"
FT                   /translation="MSRLSAAVVAIDGPAGTGKSSVSRRLARELGARFLDTGAMYRIVT
FT                   LAVLRAGADPSDIAAVETIASTVQMSLGYDPDGDSCYLAGEDVSVEIRGDAVTRAVSAV
FT                   SSVPAVRTRLVELQRTMAEGPGSIVVEGRDIGTVVFPDAPVKIFLTASAETRARRRNAQ
FT                   NVAAGLADDYDGVLADVRRRDHLDSTRAVSPLQAAGDAVIVDTSDMTEAEVVAHLLELV
FT                   TRRSEAVR"
FT   misc_feature    208378..208401
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             209031..210422
FT                   /transl_table=11
FT                   /gene="engA"
FT                   /locus_tag="Rv1713"
FT                   /product="PROBABLE GTP-BINDING PROTEIN ENGA"
FT                   /function="BINDS BOTH GDP AND GTP. HAS AN INTRINSIC GTPASE
FT                   ACTIVITY AND IS ESSENTIAL FOR CELL GROWTH."
FT                   /note="Rv1713, (MTCI125.35), len: 463 aa. Probable engA,
FT                   GTP-binding protein. Equivalent to
FT                   Q49884|MLCB1351.01|U00021_5 PROBABLE GTP-BINDING PROTEIN
FT                   ENGA from Mycobacterium leprae (461 aa), (88.6% identity in
FT                   463 aa overlap). And similar to many e.g. P50743|ENGA_BACSU
FT                   PROBABLE GTP-BINDING PROTEIN ENGA from Bacillus subtilus
FT                   (436 aa), FASTA scores: opt: 1077, E(): 0, (40.6% identity
FT                   in 434 aa overlap). Contains two PS00017 ATP/GTP-binding
FT                   site motif A (P-loop). BELONGS TO THE ERA/TRME FAMILY OF
FT                   GTP-BINDING PROTEINS. ENGA SUBFAMILY."
FT                   /db_xref="GOA:P64057"
FT                   /db_xref="HSSP:1MKY"
FT                   /db_xref="InterPro:IPR005225"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64057"
FT                   /protein_id="CAB10970.1"
FT                   /translation="MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNR
FT                   ILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMR
FT                   TADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGE
FT                   PHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGD
FT                   QRSVVHEAAGTTVDPVDSLIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDS
FT                   AEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELV
FT                   QVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGG
FT                   KQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKR
FT                   AGKRR"
FT   misc_feature    209127..209150
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   misc_feature    209646..209669
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             210596..211408
FT                   /transl_table=11
FT                   /locus_tag="Rv1714"
FT                   /product="Probable oxidoreductase"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM"
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv1714, (MTV048.01), len: 270 aa. Probable
FT                   oxidoreductase (EC 1.-.-.-) similar to many e.g.
FT                   AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281
FT                   aa), FASTA scores: opt: 578, E(): 3.3e-31, (38.9% identity
FT                   in 265 aa overlap). Also similar to several other M.
FT                   tuberculosis oxidoreductases e.g. Rv1544, etc."
FT                   /db_xref="GOA:O53927"
FT                   /db_xref="HSSP:1H5Q"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O53927"
FT                   /protein_id="CAA17611.1"
FT                   /translation="MEEMALAQQVPNLGLARFSVQDKSILITGATGSLGRVAARALADA
FT                   GARLTLAGGNSAGLAELVNGAGIDDAAVVTCRPDSLADAQQMVEAALGRYGRLDGVLVA
FT                   SGSNHVAPITEMAVEDFDAVMDANVRGAWLVCRAAGRVLLEQGQGGSVVLVSSVRGGLG
FT                   NAAGYSAYCPSKAGTDLLAKTLAAEWGGHGIRVNALAPTVFRSAVTEWMFTDDPKGRAT
FT                   REAMLARIPLRRFAEPEDFVGALIYLLSDASSFYTGQVMYLDGGYTAC"
FT   CDS             211402..212316
FT                   /transl_table=11
FT                   /gene="fadB3"
FT                   /locus_tag="Rv1715"
FT                   /product="PROBABLE 3-HYDROXYBUTYRYL-CoA DEHYDROGENASE FADB3
FT                   (BETA-HYDROXYBUTYRYL-CoA DEHYDROGENASE) (BHBD)"
FT                   /function="THOUGHT TO BE INVOLVED IN FATTY ACID
FT                   DEGRADATION. FADB AND FADA ARE THE ALPHA AND BETA SUBUNITS
FT                   OF THE MULTIFUNCTIONAL ENZYME COMPLEX OF THE FATTY ACID
FT                   DEGRADATION CYCLE [CATALYTIC ACTIVITY:
FT                   (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA +
FT                   NADPH]."
FT                   /EC_number="1.1.1.157"
FT                   /note="Rv1715, (MTV048.02), len: 304 aa. Probable fadB3,
FT                   3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), highly
FT                   similar to many e.g. NP_107236.1|NC_002678
FT                   3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti
FT                   (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA
FT                   dehydrogenase from Pseudomonas aeruginosa (509 aa);
FT                   P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA
FT                   DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA
FT                   scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa
FT                   overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA
FT                   DEHYDROGENASE FAMILY."
FT                   /db_xref="GOA:Q7D836"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D836"
FT                   /protein_id="CAE55415.1"
FT                   /translation="MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHA
FT                   AAVEAARVAGAGRGSVAAAADLAAAIPDADLVIEAVVENLAVKQELFERLATLAPDAVL
FT                   ATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQ
FT                   VGKLPVRVGRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGP
FT                   LENADYIGLDLTLAIHDAVIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWPAGARE
FT                   ATTARLAQHIAAQLQANEKGRGT"
FT   CDS             212319..213149
FT                   /transl_table=11
FT                   /locus_tag="Rv1716"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1716, (MTV048.03,MTCY04C12.01) len: 276 aa.
FT                   Conserved hypothetical protein, shows high similarity with
FT                   AF1200|O29068|AE001021_11A conserved protein of
FT                   Archaeoglobus fulgidus, gp fulgidus section 7 (278 aa),
FT                   FASTA scores: E(): 0, (61.8% identity in 251 a a overlap);
FT                   also weak similarity to several polyketide cyclases e.g.
FT                   O68500|AF048833|DPSY from Streptomyces peucetius (272 aa),
FT                   FASTA scores: opt: 194, E(): 1.7e-05, (29.6% identity in
FT                   223 aa overlap)."
FT                   /db_xref="InterPro:IPR007325"
FT                   /db_xref="UniProtKB/TrEMBL:O53929"
FT                   /protein_id="CAA17613.1"
FT                   /translation="MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMA
FT                   KSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTA
FT                   EDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDT
FT                   QALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIY
FT                   GFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAV"
FT   CDS             213149..213499
FT                   /transl_table=11
FT                   /locus_tag="Rv1717"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1717, (MTCY04C12.02), len: 116 aa. Conserved
FT                   hypothetical protein, similar to O29060|AF1208|AE001021
FT                   Hypothetical protein from Arecheoglobus fulgidus (114 aa),
FT                   FASTA scores: opt: 254, E(): 3.3e-09, (37.7% identity in
FT                   114 aa overlap)."
FT                   /db_xref="InterPro:IPR014710"
FT                   /db_xref="UniProtKB/TrEMBL:O86372"
FT                   /protein_id="CAA17614.1"
FT                   /translation="MKLTRASQAPRYVAPAHHEVSTMRLQGREAGRTERFWVGLSVYRP
FT                   GGTAEPAPTREETVYVVLDGELVVTVDGAETVLGWLDSVHLAKGELRSIHNRTDRQALL
FT                   LVTVAHPVAEVA"
FT   repeat_region   213499..213551
FT                   /note="53 bp Mycobacterial Interspersed Repetitive Unit,
FT                   Class II"
FT   CDS             213552..214370
FT                   /transl_table=11
FT                   /locus_tag="Rv1718"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1718, (MTCY04C12.03), len: 272 aa. Conserved
FT                   hypothetical protein, similar to O29058|AF1210|AE001021
FT                   Hypothetical protein from Archeoglobus (313 aa), FASTA
FT                   scores: opt: 301, E(): 8e-23, (31.6% identity in 301 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR008567"
FT                   /db_xref="UniProtKB/TrEMBL:P71976"
FT                   /protein_id="CAB03702.1"
FT                   /translation="MSIVITVAPTGPIATKADNPALPTSPEEIATAVEQAYHAGAAVAH
FT                   IHLRDENERPTADPNIARRAMDLIGERCPILIQLSTGVGLTVPFEQREQLVELRPRMAT
FT                   LNPCSMSFGAGEFRNPPQAVRRLAARMRELDIKPELEIYDTGHLEACLRLWAEDLLAEP
FT                   LQFSIVLGVRGGMAATADNLLTMVRRLPPGAIWQVIAIGKANMELTAMGLALGGNARVG
FT                   LEDTLYLRKGELAPSNLALVSRTIRLAEALDLPIASVEEAEAALQLPGTS"
FT   CDS             214384..215163
FT                   /transl_table=11
FT                   /locus_tag="Rv1719"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv1719, (MTCY04C12.04), len: 259 aa. Probable
FT                   transcriptional regulatory protein, similar to
FT                   YIAJ_ECOLI|P37671 hypothetical transcriptional regulator
FT                   from Escherichia coli (282 aa), FASTA scores: opt: 353,
FT                   E(): 3.2e-15, (31.1% identity in 235 aa overlap). Similar
FT                   to Mycobacterium tuberculosis hypothetical IclR-family
FT                   transcriptional regulators Rv2989, Rv1773c.
FT                   Helix-turn-helix motif from aa 34-55 (+6.94 SD)."
FT                   /db_xref="GOA:P71977"
FT                   /db_xref="HSSP:1HW5"
FT                   /db_xref="InterPro:IPR014757"
FT                   /db_xref="UniProtKB/TrEMBL:P71977"
FT                   /protein_id="CAB03703.1"
FT                   /translation="MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQAEIGERVGMA
FT                   RSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVRLGVVTEMHPFLTELSRELD
FT                   ETVDLSILDGDRADVVDQVVPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQARAL
FT                   PSRLAPLTANTITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLRGVSVELVAVS
FT                   VPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK"
FT   tRNA            215356..215429
FT                   /gene="tRNA-Pro(GGG)"
FT                   /product="transfer RNA-Pro(GGG)"
FT                   /anticodon=(pos:215390..215392,aa:Pro)
FT   CDS             complement(215773..216162)
FT                   /transl_table=11
FT                   /locus_tag="Rv1720c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1720c, (MTCY04C12.05c), len: 129 aa. Conserved
FT                   hypothetical protein, similar to other Mycobacterium
FT                   tuberculosis hypothetical proteins e.g.
FT                   O53610|Rv0065|MTV030.08 (133 aa), FASTA scores: E():
FT                   1.5e-10, (39.1% identity in 128 aa overlap);
FT                   P71550|Rv0960|MTCY10D7.14C (129 aa) and
FT                   O06415|Rv0549c|MTCY25D10.28C (137 aa)."
FT                   /db_xref="UniProtKB/TrEMBL:P71978"
FT                   /protein_id="CAB03704.1"
FT                   /translation="MIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAI
FT                   RQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFTQRAYQLRSTHTVADGAYVALAEGL
FT                   GVPLITCDGRLAQSHGHNAEIELVA"
FT   CDS             complement(216159..216386)
FT                   /transl_table=11
FT                   /locus_tag="Rv1721c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1721c, (MTCY04C12.06c), len: 75 aa. Conserved
FT                   hypothetical protein, similar to Rv0300|MTCY63.05|O07227
FT                   CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium
FT                   tuberculosis (73 aa). Start changed since original
FT                   submission."
FT                   /db_xref="UniProtKB/TrEMBL:P71979"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB03705.2"
FT                   /translation="MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPA
FT                   LDDVLDRLAALPRRDLGASAAELVDEARSE"
FT   CDS             216604..218088
FT                   /transl_table=11
FT                   /locus_tag="Rv1722"
FT                   /product="POSSIBLE CARBOXYLASE"
FT                   /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID
FT                   METABOLISM"
FT                   /note="Rv1722, (MTCY04C12.07), len: 494 aa. Possible
FT                   carboxylases. Weak similarity to several e.g.
FT                   ACCC_BACSU|P49787 biotin carboxylase from Bacillus subtilis
FT                   (448 aa), fasta scores: opt: 171, E(): 0.00021, (22.8%
FT                   identity in 237 aa overlap)."
FT                   /db_xref="GOA:P71980"
FT                   /db_xref="InterPro:IPR011761"
FT                   /db_xref="UniProtKB/TrEMBL:P71980"
FT                   /protein_id="CAB03706.1"
FT                   /translation="MIVPAREPEPQPRRVLNGLSDVRAFFHNNTVPLYFISPTPFNLLG
FT                   IYRWIRNFFYLTYYDSFEGEHSRVFVPRRRDRRDFDGMGDVCNHLLRDPETLEFIKNRG
FT                   PGGKACFVMLDEETQALARQAGLEVMHPPAELRHRLESKIVMTRLADEAGVPSVPHVIG
FT                   RVSSYDELSALAHGAGLGDDLVVEAAYGNAGSATFFVRGLRDWDQCAGGIVGQPEIKVM
FT                   KRIRNVEVCIEATVTRHGTVIGPAMTSLVGYPELTPYRGAWCGNDVWRGALPPAQTRAA
FT                   REMVAKLGDVLSREGYRGYFEVDLLHDLDADELYLGEVNPRLSGASPMTNLTTEAYADM
FT                   PLFLFHLLEYMDVDYELDIEAINSRWERGYGEDEVWGQLIMSETSPDLELFTATPRTGM
FT                   WRLNHDGRVSFARQGNDWATMLDESEAFYMRVAAPGDLRCEGAQLGVLVTRGHLQTDDY
FT                   QLTERGRRWIDGLKAQFASTPLTPAAPIVSRLVARA"
FT   CDS             218085..219332
FT                   /transl_table=11
FT                   /locus_tag="Rv1723"
FT                   /product="PROBABLE HYDROLASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM"
FT                   /EC_number="3.-.-.-"
FT                   /note="Rv1723, (MTCY04C12.08), len: 415 aa. Possible
FT                   hydrolase (EC 3.-.-.-), similar to others e.g.
FT                   NYLB_FLASP|P07061 6-aminohexanoate-dimer hydrolase from
FT                   Flavobacterium sp. (392 aa), FASTA scores: opt: 717, E():
FT                   0, (35.1% identity in 396 aa overlap). Also similar to M.
FT                   tuberculosis hypothetical esterases and penicillin binding
FT                   proteins e.g. Rv1923, Rv1497, Rv2463, etc"
FT                   /db_xref="GOA:P71981"
FT                   /db_xref="InterPro:IPR001466"
FT                   /db_xref="UniProtKB/TrEMBL:P71981"
FT                   /protein_id="CAB03707.1"
FT                   /translation="MSGGVPAGLALDNWLSSPYSHWAFQHVEDFMPTTVIARGTEPVVT
FT                   LPADNAPIADIGLTSTDGIATTVGAVMAATATDGWAVAHRGALVAEQYLDGLGPRTRHL
FT                   LFSVSKSLVAAVVGALHGAGAIELDAPVTAYVPALADCGYAGATVRHLLDMRSGVAFSE
FT                   NYDDPAAEIHVREQVIGWAPKRGPDLPATLRDYLLTLRRKSAHGGPFEYRSCETDVLGW
FT                   ICEAAAGQPMPELMSELLWSRIGAQCDATIALDVAGAAGTGIFDGGISACLTDMIRFGS
FT                   LYLRDGVSLAGQQVVPAAWIADTFDGGPDSRQAFAASPDDNPMPGGMYRNQVWFPYPGS
FT                   NVALCVGMCGQLIYVNRAAEVVAAKLSTQPHSHEPHMLDTLRAFDAVAHELSGIRSSST
FT                   NDPQRPSPPAQEASPG"
FT   CDS             complement(219375..219794)
FT                   /transl_table=11
FT                   /locus_tag="Rv1724c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1724c, (MTCY04C12.09c), len: 139 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:P71982"
FT                   /protein_id="CAB03708.1"
FT                   /translation="MVGNEENELQDLRNLRRPCFSRAEAPIGVYNGEQAIIVYDLRPVP
FT                   HWPKYWIQALAKHFQRQLKPSPKIDISLLDDRIRFSVFVSTDVSAKDLCKLDDAVYNAV
FT                   RNAGRAIENEQAALDHKLAEVRKRRMDTWDESYFR"
FT   CDS             complement(219784..220494)
FT                   /transl_table=11
FT                   /locus_tag="Rv1725c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1725c, (MTCY04C12.10c), len: 236 aa. Conserved
FT                   hypothetical protein, similar to other hypothetical
FT                   proteins from diverse organisms e.g. P70885|U44893 ORF108
FT                   from BUTYRIVIBRIO FIBRISOLVENS, (108 aa), FASTA scores:
FT                   opt: 223, E(): 2e-09, (39.1% identity in 92 aa overlap).
FT                   Also similar to Mycobacterium tuberculosis hypothetical
FT                   transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158
FT                   aa)."
FT                   /db_xref="InterPro:IPR002577"
FT                   /db_xref="UniProtKB/TrEMBL:P71983"
FT                   /protein_id="CAB03709.1"
FT                   /translation="MQPYGQYCPVARAAELLGDRWTLLIVRELLFGPLRFTEIERGLPG
FT                   ISRSVLAQRLRRLQHDRIIEAVPEHTGGGYRFTVAGEELRPVLQTLGDWVSRWLMADPT
FT                   PAECDPELLTLWISRRVNTEALPGRRVVVEFRYHGERPLWAWLVLEPGDISVCLHDPCL
FT                   PVDLTVRGHPRDLYRVYSGRSTLAAEISAERIELDGLPAMRRAFPSWMAWSPFAPAMRQ
FT                   AVVSVDQMPEAHGG"
FT   CDS             220595..221980
FT                   /transl_table=11
FT                   /locus_tag="Rv1726"
FT                   /product="PROBABLE OXIDOREDUCTASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM"
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv1726, (MTCY04C12.11), len: 461 aa. Probable
FT                   oxidoreductase (EC 1.-.-.-), similar to HDNO_ARTOX|P08159
FT                   6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt:
FT                   678, E(): 0, (29.5% identity in 465 aa overlap). Also
FT                   similar to Mycobacterium tuberculosis hypothetical
FT                   dehydrogenases e.g. Rv3107c, Rv1257c, etc."
FT                   /db_xref="GOA:P71984"
FT                   /db_xref="InterPro:IPR016168"
FT                   /db_xref="UniProtKB/TrEMBL:P71984"
FT                   /protein_id="CAB03710.1"
FT                   /translation="MTATLTKTLGSLDDFRGTLCVPGDPDYPRVRAIWNGQVAREPALI
FT                   ATCHDACDVRTVLRRAVDAGMVTAVRGGGHNVAGTALCDGGVVIDLSAMRAVSLDPATG
FT                   RVRVQGGATLADLDHATVPFARVAPAGIVTTTGVGGLTLGGGVGWTTRRFGLSCDNLVA
FT                   VRLVTAAGDYLSVDDERDPELMWGLRGGGGNFGIVTEFEFATHPFGPVAVAGFVVYRLD
FT                   DGPAVLRGYRQFAAAAPEEVTTIVVLRHAPPAPWIPVDQRGKPVVMIGAVHTGSIQTGI
FT                   EALRPVKSLARPVADTVWPTPFLAHQAVLDASNPAGHRYYWKSDHLAELNDEAIDLLVE
FT                   QTAQLSSPDSLIGIFQLGGAAARGGERSCFPSRHARFMVNYATHWTEAREDDLHRQWTR
FT                   DAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLKNRLDPDNVFRNNHNIR
FT                   PSA"
FT   CDS             222013..222582
FT                   /transl_table=11
FT                   /locus_tag="Rv1727"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1727, (MTCY04C12.12), len: 189 aa. Conserved
FT                   hypothetical protein, similar to Mycobacterium tuberculosis
FT                   hypothetical proteins P72040|Rv3773c|MTCY13D12.07C (194
FT                   aa), FASTA scores: opt: 176, E(): 2.7e-08, (31.1% identity
FT                   in 180 aa overlap); and O53801|Rv0738 (182 aa)."
FT                   /db_xref="InterPro:IPR017520"
FT                   /db_xref="UniProtKB/TrEMBL:P71985"
FT                   /protein_id="CAB03711.1"
FT                   /translation="MDLYSNLVEAEQRLVALVSSIEADSYSSPTPCDRWDVRALLSHAL
FT                   ASIDAFAAAVDGAPGPDMAQVFSGADIVGDDPLGATQRITRRSQAAWSTVRDLNAELST
FT                   FIGVMPAGQALAIITFSTVVHGWDLAVATGQAGELPEHLAEAAQQVAAELVPVLRPRGL
FT                   FAHDVDLAGEATPTQRLVALTGRKPR"
FT   CDS             complement(222607..223377)
FT                   /transl_table=11
FT                   /locus_tag="Rv1728c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1728c, (MTCY04C12.13c), len: 256 aa. Conserved
FT                   hypothetical protein, some similarity to
FT                   O07246|Rv0320|MTCY63.25 possible exported protein from
FT                   Mycobacterium tuberculosis (220 aa), FASTA scores: E():
FT                   1.3e-31, (42.3% identity in 220 aa overlap). C-terminal
FT                   region similar to Q9ZX60|AF068845|AF068845_17 segment of
FT                   gp17 of Mycobacteriophage TM4 (1229 aa), FASTA scores: opt:
FT                   385, E(): 4.3e-17, (44.6% identity in 139 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:P71986"
FT                   /protein_id="CAB03712.1"
FT                   /translation="MSVNGLPGAHNAGLQPIDSKGCHTRRTRHTKVLFVSKGVLANGRG
FT                   RWLAIAASLVVSAAILYAQGAEHTCCRETPAAIPTGPDSAPANAPRIASPTEADLLAAS
FT                   APVAAQQFQFALPAGVASEEGLQVKTIWVARAVSVLFPQITNIFGYRQDPLKWHPNGLA
FT                   IDVMIPNHHSDEGIQLGNQVAGLALANAKRWGVLHVIWRQGYYPGIGAPSWTADYGSET
FT                   LNHYDHVHIATDGGGYPTGRETYYVGSMSPTPPE"
FT   CDS             complement(223374..224312)
FT                   /transl_table=11
FT                   /locus_tag="Rv1729c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1729c, (MTCY04C12.14c), len: 312 aa. Conserved
FT                   hypothetical protein, similar to many Mycobacterium
FT                   tuberculosis hypothetical proteins e.g.
FT                   Q50726|Rv3399|YX99_MYCTU (348 aa), FASTA scores: opt: 1019,
FT                   E(): 0, (55.7% identity in 296 aa overlap); P95074|Rv0726c
FT                   (367 aa), O53795|Rv0731c (318 aa), and O53841|Rv0830 (301
FT                   aa), etc."
FT                   /db_xref="GOA:P71987"
FT                   /db_xref="InterPro:IPR003455"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71987"
FT                   /protein_id="CAB03713.1"
FT                   /translation="MARTDDDNWDLTSSVGVTATIVAVGRALATKDPRGLINDPFAEPL
FT                   VRAVGLDLFTKMMDGELDMSTIADVSPAVAQAMVYGNAVRTKYFDDYLLNATAGGIRQV
FT                   AILASGLDSRAYRLPWPTRTVVYEIDQPKVMEFKTTTLADLGAEPSAIRRAVPIDLRAD
FT                   WPTALQAAGFDSAAPTAWLAEGLLIYLKPQTQDRLFDNITALSAPGSMVATEFVTGIAD
FT                   FSAERARTISNPFRCHGVDVDLASLVYTGPRNHVLDYLAAKGWQPEGVSLAELFRRSGL
FT                   DVRAADDDTIFISGCLTDHSSISPPTAAGWR"
FT   CDS             complement(224435..225988)
FT                   /transl_table=11
FT                   /locus_tag="Rv1730c"
FT                   /product="POSSIBLE PENICILLIN-BINDING PROTEIN"
FT                   /function="THOUGHT TO BE INVOLVED IN CELL WALL BIOSYNTHESIS
FT                   AND MAY ALSO ACT AS A SENSOR OF EXTERNAL PENICILLINS"
FT                   /note="Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible
FT                   penicillin-binding protein, similar to others e.g.
FT                   PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from
FT                   Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,
FT                   E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also
FT                   similar to other Mycobacterium tuberculosis hypothetical
FT                   penicillin binding proteins and esterases e.g. Rv1923,
FT                   Rv1497, etc."
FT                   /db_xref="InterPro:IPR001466"
FT                   /db_xref="UniProtKB/TrEMBL:P71988"
FT                   /protein_id="CAB03693.1"
FT                   /translation="MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVV
FT                   ETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDG
FT                   DTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNH
FT                   TAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGT
FT                   TYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTG
FT                   GLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWM
FT                   LRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQR
FT                   FAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDD
FT                   ANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ
FT                   "
FT   CDS             226420..227976
FT                   /transl_table=11
FT                   /gene="gabD2"
FT                   /locus_tag="Rv1731"
FT                   /standard_name="gabD1"
FT                   /product="POSSIBLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE
FT                   [NADP+] DEPENDENT (SSDH) GABD2"
FT                   /function="INVOLVED IN 4-AMINOBUTYRATE (GABA) DEGRADATION
FT                   PATHWAY [CATALYTIC ACTIVITY: SUCCINATE SEMIALDEHYDE +
FT                   NAD(P)(+) + H(2)O = SUCCINATE + NAD(P)H]."
FT                   /EC_number="1.2.1.16"
FT                   /note="Rv1731, (MTCY04C12.16), len: 518 aa. Possible gabD2,
FT                   succinate-semialdehyde dehydrogenase [NADP+] dependent (EC
FT                   1.2.1.16), similar to others e.g. GABD_ECOLI|P25526
FT                   succinate-semialdehyde dehydrogenase from Escherichia coli
FT                   (482 aa), FASTA scores: opt: 870, E(): 0, (34.7% identity
FT                   in 449 aa overlap); etc. Also similar to
FT                   gabD1|Rv0234c|MTCY08D5.30c PROBABLE SUCCINATE-SEMIALDEHYDE
FT                   DEHYDROGENASE [NADP+] DEPENDENT from Mycobacterium
FT                   tuberculosis (511 aa); and other semialdehyde
FT                   dehydrogenases e.g. Rv0768|aldA (489 aa), Rv2858c|aldC (455
FT                   aa), etc. Contains PS00216 Sugar transport proteins
FT                   signature 1, PS00687 Aldehyde dehydrogenases glutamic acid
FT                   active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.
FT                   Note that previously known as gabD1."
FT                   /db_xref="GOA:P96417"
FT                   /db_xref="HSSP:1AG8"
FT                   /db_xref="InterPro:IPR015590"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96417"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB07016.2"
FT                   /translation="MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGT
FT                   AADVEAAFAEARAAQTDWAKRPVIERAAVIRRYRDLVIENREFLMDLLQAEAGKARWAA
FT                   QEEIVDLIANANYYARVCVDLLKPRKAQPLLPGIGKTTVCYQPKGVVGVISPWNYPMTL
FT                   TVSDSVPALVAGNAVVLKPDSQTPYCALACAELLYRAGLPRALYAIVPGPGSVVGTAIT
FT                   DNCDYLMFTGSSATGSRLAEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACF
FT                   SNAGQLCISIERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVS
FT                   GHVDDATAKGAKVIAGGKARPDIGPLFYEPTVLTNVAPEMECAANETFGPVVSIYPVAD
FT                   VDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGTVNVDEGYAFAWGSLSAPMGGM
FT                   GLSGVGRRHGPEGLLKYTESQTIATARVFNLDPPFGIPATVWQKSLLPIVRTVMKLPGR
FT                   R"
FT   misc_feature    227128..227178
FT                   /note="PS00216 Sugar transport proteins signature 1"
FT   misc_feature    227176..227199
FT                   /note="PS00687 Aldehyde dehydrogenases glutamic acid active
FT                   site"
FT   CDS             complement(227986..228534)
FT                   /transl_table=11
FT                   /locus_tag="Rv1732c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1732c, (MTCY04C12.17c), len: 182 aa. Conserved
FT                   hypothetical protein, highly similar to hypothetical
FT                   proteins from several organisms e.g. P73178|SLL1289|D90904
FT                   from Synechocystis (194 aa), FASTA scores: opt: 663, E():
FT                   0, (53.1% identity in 179 aa overlap); etc."
FT                   /db_xref="GOA:P71990"
FT                   /db_xref="InterPro:IPR017936"
FT                   /db_xref="UniProtKB/TrEMBL:P71990"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB03695.1"
FT                   /translation="MAVESSMLALGTPAPSFTLPQPATGATVSLDELTGPALVVTFICN
FT                   HCPYVQHVAAGLATLGRDLADQGVPMVGISSNDVVTYPQDGPDQMVAEARRHGWTFPYL
FT                   YDETQDVARAFSAACTPDTFVFDGQRRLVYRGQLDDSRPGNGRPVTAADVRAAVDALLA
FT                   GRPVNPDQRPSIGCGIKWR"
FT   CDS             complement(228598..229230)
FT                   /transl_table=11
FT                   /locus_tag="Rv1733c"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1733c, (MTCY04C12.18c), len: 210 aa. Probable
FT                   conserved transmembrane protein. Similar to
FT                   AL109962|SCJ1_26 hypothetical protein from Streptomyces
FT                   coelicolor (193 aa), FASTA scores: opt: 287, E(): 3.8e-11,
FT                   (35.2% identity in 182 aa overlap)."
FT                   /db_xref="GOA:P71991"
FT                   /db_xref="UniProtKB/TrEMBL:P71991"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB03696.1"
FT                   /translation="MIATTRDREGATMITFRLRLPCRTILRVFSRNPLVRGTDRLEAVV
FT                   MLLAVTVSLLTIPFAAAAGTAVQDSRSHVYAHQAQTRHPATATVIDHEGVIDSNTTATS
FT                   APPRTKITVPARWVVNGIERSGEVNAKPGTKSGDRVGIWVDSAGQLVDEPAPPARAIAD
FT                   AALAALGLWLSVAAVAGALLALTRAILIRVRNASWQHDIDSLFCTQR"
FT   CDS             complement(229517..229759)
FT                   /transl_table=11
FT                   /locus_tag="Rv1734c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1734c, (MTCY04C12.19c), len: 80 aa. Conserved
FT                   hypothetical protein, similar to C-terminal region
FT                   Q9Z8N2|CP0452|AE001615 Dihydrolipoamide Acetyltransferase
FT                   from Chlamydia pneumoniae (429 aa), FASTA scores: opt: 138,
FT                   E(): 0.0012, (26.9% identity in 78 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:P71992"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB03697.1"
FT                   /translation="MTNVGDQGVDAVFGVIYPPQVALVSFGKPAQRVCAVDGAIHVMTT
FT                   VLATLPADHGCSDDHRGALFFLSINELTRCAAVTG"
FT   CDS             complement(230034..230531)
FT                   /transl_table=11
FT                   /locus_tag="Rv1735c"
FT                   /product="HYPOTHETICAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1735c, (MTCY04C12.20c), len: 165 aa. Hypothetical
FT                   membrane protein, similar to part of O58614|PH0884|AP000004
FT                   Hypothetical malic acid transport protein from Pyrococcus
FT                   horikoshii (330 aa), FASTA scores: opt: 167, E(): 0.0003,
FT                   (29.2% identity in 120 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:P71993"
FT                   /protein_id="CAB03698.1"
FT                   /translation="MGATAITVLAGAHIVEMADAPMAIVTSGLVAGASVVFWAFGPWLI
FT                   PPLVAASIWKHVVHRVPLRYEATLWSVVFPLGMYGVGAYRLGLAAHLPIVESIGEFEGW
FT                   VALAVWTITFVAMLHHLAATIGRSGRSSHAIGAADDTHAIICRPPRSFDHQVRAFRRNQ
FT                   PM"
FT   CDS             complement(230971..232929)
FT                   /transl_table=11
FT                   /gene="narX"
FT                   /locus_tag="Rv1736c"
FT                   /product="PROBABLE NITRATE REDUCTASE NARX"
FT                   /function="INVOLVED IN NITRATE REDUCTION, AND IN THE
FT                   PERSISTENCE IN THE HOST [CATALYTIC ACTIVITY: Nitrite +
FT                   acceptor = nitrate + reduced acceptor]"
FT                   /EC_number="1.7.99.4"
FT                   /note="Rv1736c, (MTCY04C12.21c), len: 652 aa. Probable
FT                   narX, nitrate reductase (EC 1.7.99.4). Contains three
FT                   domains: N-terminus (250 aa) is similar to e.g. N-terminus
FT                   of NARG_ECOLI|P09152 respiratory nitrate reductase 1 alpha
FT                   chain from Escherichia coli (1246 aa), FASTA scores: E():
FT                   0, (58.6% identity in 251 aa overlap); and
FT                   Rv1161|MTCI65.28|NARG PROBABLE RESPIRATORY NITRATE
FT                   REDUCTASE (ALPHA CHAIN) from Mycobacterium tuberculosis
FT                   (1232 aa). Central region (260-410 aa) is similar to
FT                   Rv1163|O06561|NARJ PROBABLE RESPIRATORY NITRATE REDUCTASE
FT                   (DELTA CHAIN) from Mycobacterium tuberculosis (201 aa),
FT                   FASTA scores: E(): 0, (64.2% identity in 159 aa overlap).
FT                   C-terminus (420 aa-) is similar to Rv1164|O06562|NARI
FT                   PROBABLE RESPIRATORY NITRATE REDUCTASE (GAMMA CHAIN) from
FT                   Mycobacterium tuberculosis (246 aa), FASTA scores: E(): 0,
FT                   (68.6% identity in 239 aa overlap). Contains PS00551
FT                   Prokaryotic molybdopterin oxidoreductases signature 1."
FT                   /db_xref="GOA:P71994"
FT                   /db_xref="HSSP:1Q16"
FT                   /db_xref="InterPro:IPR006656"
FT                   /db_xref="UniProtKB/TrEMBL:P71994"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB03699.1"
FT                   /translation="MTVTPRTGSRIEELLARSGRFFIPGEISADLRTVTRRGGRDGDVF
FT                   YRDRWSHDKVVRSTHGVNCTGSCSWKIYVKDDIITWETQETDYPSVGPDRPEYEPRGCP
FT                   RGAAFSWYTYSPTRVRHPYARGVLVEMYREAKARLGDPVAAWADIQADPRRRRRYQRAR
FT                   GKGGLVRVSWAEATEMIAAAHVHTISTYGPDRVAGFSPIPAMSMVSHAAGSRFVELIGG
FT                   VMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDVVWQCASVLLTYPNSRQLGTAEELL
FT                   AHIDGPAADLLGRTVSELRRADPLTAATRYVDTFDLRGRATLYLTYWTAGDTRNRGREM
FT                   LAFAQTYRSTDVAPPRGETPDFLPVVLEFAATVDPEAGRRLLSGYRVPIAALCNALTEA
FT                   ALPYAHTVAAVCRTGDMMGELFWTVVPYVTMTIVAVGSWWRYRYDKFGWTTRSSQLYES
FT                   RLLRIASPMFHFGILVVIVGHGIGLVIPQSWTQAAGLSEGAYHVQAVVLGSIAGITTLA
FT                   GVTLLIYRRRTRGPVFMATTVNDKVMYLVLVAAIVAGLGATALGSGVVGEAYNYRETVS
FT                   VWFRSVWVLQPRGDLMAEAPLYYQIHVLIGLALFALWPFTRLVHAFSAPIGYLFRPYII
FT                   YRSREELVLTRPRRRGW"
FT   misc_feature    complement(232699..232758)
FT                   /note="PS00551 Prokaryotic molybdopterin oxidoreductases
FT                   signature 1"
FT   CDS             complement(232926..234113)
FT                   /transl_table=11
FT                   /gene="narK2"
FT                   /locus_tag="Rv1737c"
FT                   /product="POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2"
FT                   /function="INVOLVED IN EXCRETION OF NITRITE, PRODUCED BY
FT                   THE DISSIMILATORY REDUCTION OF NITRATE, ACROSS THE
FT                   MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE
FT                   SUBSTRATE ACROSS THE MEMBRANE."
FT                   /note="Rv1737c, (MTCY04C12.22c), len: 395 aa. Possible
FT                   narK2, nitrate/nitrite-transport integral membrane protein
FT                   (see Hutter & Dick 2000), possibly member of major
FT                   facilitator superfamily (MFS), similar to P46907|NARK_BACSU
FT                   nitrite extrusion protein from Bacillus subtilis (395 aa),
FT                   FASTA scores: opt: 742, E(): 0, (33.6% identity in 375 aa
FT                   overlap); and to AL109989|SCJ12.23 hypothetical
FT                   nitrate/nitrite transporter from Streptomyces coelicolor
FT                   (412 aa), FASTA scores: opt: 1181, E(): 0, (49.4% identity
FT                   in 389 aa overlap)."
FT                   /db_xref="InterPro:IPR011701"
FT                   /db_xref="UniProtKB/TrEMBL:P71995"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB03700.1"
FT                   /translation="MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARDMSLSSAEASL
FT                   LVATPILVGALGRIVTGPLTDRFGGRAMLIAVTLASILPVLAVGVAATMGSYALLVFFG
FT                   LFLGVAGTIFAVGIPFANNWYQPARRGFSTGVFGMGMVGTALSAFFTPRFVRWFGLFTT
FT                   HAIVAAALASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIVFGGF
FT                   VAFSNYLPTYITTIYGFSTVDAGARTAGFALAAVLARPVGGWLSDRIAPRHVVLASLAG
FT                   TALLAFAAALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAASVGSVTGIVAAA
FT                   GGLGGYFPPLVMGATYDPVDNDYTVGLLLLVATALVACTYTALHAREPVSEEASR"
FT   CDS             234400..234684
FT                   /transl_table=11
FT                   /locus_tag="Rv1738"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1738, (MTCY04C12.23), len: 94 aa. Conserved
FT                   hypothetical protein, similar to P71931|Rv2632c|YQ32_MYCTU
FT                   Hypothetical 10.1 kDa protein from Mycobacterium
FT                   tuberculosis (93 aa), FASTA scores: opt: 319, E(): 2.6e-27,
FT                   (53.9% identity in 89 aa overlap)."
FT                   /db_xref="InterPro:IPR015057"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64887"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB03714.1"
FT                   /translation="MCGDQSDHVLQHWTVDISIDEHEGLTRAKARLRWREKELVGVGLA
FT                   RLNPADRNVPEIGDELSVARALSDLGKRMLKVSTHDIEAVTHQPARLLY"
FT   CDS             complement(234698..236380)
FT                   /transl_table=11
FT                   /locus_tag="Rv1739c"
FT                   /product="PROBABLE SULPHATE-TRANSPORT TRANSMEMBRANE PROTEIN
FT                   ABC TRANSPORTER"
FT                   /function="INVOLVED IN SULPHATE TRANSPORT ACROSS THE
FT                   MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE
FT                   SUBSTRATE ACROSS THE MEMBRANE."
FT                   /note="Rv1739c, (MTCY04C12.24c, MTCY28.01), len: 560 aa.
FT                   Probable sulphate-transport transmembrane protein ABC
FT                   transporter, similar to several e.g. P53392|G607186 high
FT                   affinity sulphate transporter from Stylosanthes hamata (662
FT                   aa), FASTA scores: opt: 382, E(): 1.6e-16, (28.0% identity
FT                   in 564 aa overlap); U59234.1|AAB88215.1 biotin carb. from
FT                   Synechococcus sp. PCC 7942 (574 aa), FASTA scores: opt:
FT                   1838, E(): 0, (50.0% identity in 550 aa overlap); etc.
FT                   Contains PS00211 ABC transporters family signature. BELONGS
FT                   TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC
FT                   TRANSPORTERS), AND SEEMS TO BELONG TO THE SULP FAMILY."
FT                   /db_xref="GOA:P71997"
FT                   /db_xref="InterPro:IPR001902"
FT                   /db_xref="UniProtKB/TrEMBL:P71997"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB03701.1"
FT                   /translation="MIPTMTSAGWAPGVVQFREYQRRWLRGDVLAGLTVAAYLIPQAMA
FT                   YATVAGLPPAAGLWASIAPLAIYALLGSSRQLSIGPESATALMTAAVLAPMAAGDLRRY
FT                   AVLAATLGLLVGLICLLAGTARLGFLASLRSRPVLVGYMAGIALVMISSQLGTITGTSV
FT                   EGNEFFSEVHSFATSVTRVHWPTFVLAMSVLALLTMLTRWAPRAPGPIIAVLAATMLVA
FT                   VMSLDAKGIAIVGRIPSGLPTPGVPPVSVEDLRALIIPAAGIAIVTFTDGVLTARAFAA
FT                   RRGQEVNANAELRAVGACNIAAGLTHGFPVSSSSSRTALADVVGGRTQLYSLIALGLVV
FT                   IVMVFASGLLAMFPIAALGALVVYAALRLIDLSEFRRLARFRRSELMLALATTAAVLGL
FT                   GVFYGVLAAVALSILELLRRVAHPHDSVLGFVPGIAGMHDIDDYPQAKRVPGLVVYRYD
FT                   APLCFANAEDFRRRALTVVDQDPGQVEWFVLNAESNVEVDLTALDALDQLRTELLRRGI
FT                   VFAMARVKQDLRESLRAASLLDKIGEDHIFMTLPTAVQAFRRR"
FT   misc_feature    complement(236051..236095)
FT                   /note="PS00211 ABC transporters family signature"
FT   CDS             236448..236660
FT                   /transl_table=11
FT                   /locus_tag="Rv1740"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1740, (MTCY28.02-MTCY04C12.25), len: 70 aa.
FT                   Conserved hypothetical protein, highly similar to other
FT                   Mycobacterium tuberculosis hypothetical proteins e.g.
FT                   P96913|Rv0623|MTCY20H10.04 (84 aa), (73.5% identity in 68
FT                   aa overlap); P71998|Rv1740 (70 aa), and O07770|Rv0608 (81
FT                   aa)."
FT                   /db_xref="InterPro:IPR011660"
FT                   /db_xref="UniProtKB/TrEMBL:P71998"
FT                   /protein_id="CAB09326.1"
FT                   /translation="MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRR
FT                   CAALPVLDTRAADTILGYDERGLPA"
FT   CDS             236660..236908
FT                   /transl_table=11
FT                   /locus_tag="Rv1741"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1741, (MTCY28.03,MTCY04C12.26), len: 82 aa.
FT                   Conserved hypothetical protein, very similar in N-terminus
FT                   to other Mycobacterium tuberculosis hypothetical proteins
FT                   e.g. P96914|Rv0624|MTCY20H10.05 (131 aa), (80.4% identity
FT                   in 56 aa overlap); P71999|Rv1741 (82 aa) and O07769|Rv0609
FT                   (133 aa)."
FT                   /db_xref="UniProtKB/TrEMBL:P71999"
FT                   /protein_id="CAB09327.1"
FT                   /translation="MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVI
FT                   ETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVLAG"
FT   CDS             236916..237653
FT                   /transl_table=11
FT                   /locus_tag="Rv1742"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1742, (MTCY28.04,MTCY04C12.27), len: 245 aa.
FT                   Hypothetical unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O33271"
FT                   /protein_id="CAB09328.1"
FT                   /translation="MSALLDGVLDAHGGLQRWRAAETVHGRVRTGGLLLRTRVPGNRFA
FT                   DYRITVHVQQARTVLDPFPRDGYRGVFESGQVRIESHDGAVISSRAHPRAAFFGRSGLR
FT                   RNIRWDPLDSVYFAGYAMWNYLTTPYLLTREGVAVEEGAPWQQEGETWRRLIVSFPPDI
FT                   DTHSPRQTFYVDASGLLRRHDYVPEVVGHWARAAHYCADPVDVDGFVFPTCRWVHPIGP
FT                   GNRSLPFPTLVSILLTDIRVETD"
FT   CDS             237747..239447
FT                   /transl_table=11
FT                   /gene="pknE"
FT                   /locus_tag="Rv1743"
FT                   /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN
FT                   KINASE E PKNE (PROTEIN KINASE E) (STPK E)"
FT                   /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA
FT                   PHOSPHORYLATION). THOUGHT TO BE INVOLVED IN MEMBRANE
FT                   TRANSPORT [CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A
FT                   PHOSPHOPROTEIN]."
FT                   /EC_number="2.7.1.-"
FT                   /note="Rv1743, (MTCY28.05,MTCY04C12.28), len: 566 aa.
FT                   Probable pknE, transmembrane serine/threonine protein
FT                   kinase (EC 2.7.1.-) (see citation below), similar to
FT                   PKN1_MYXXA|P33973 serine/threonine-protein kinase pkn1 (693
FT                   aa), fasta scores: opt: 542, E(): 1.1e-19, (35.8% identity
FT                   in 302 aa overlap). Also highly similar to
FT                   K08G_MYCTU|Q11053 probable serine/threonine-protein kinase
FT                   (626 aa) (59.8% identity in 381 aa overlap). Contains
FT                   PS00107 Protein kinases ATP-binding region signature.
FT                   Contains Hank's kinase subdomain. BELONGS TO THE SER/THR
FT                   FAMILY OF PROTEIN KINASES."
FT                   /db_xref="GOA:P72001"
FT                   /db_xref="InterPro:IPR008271"
FT                   /db_xref="PDB:2H34"
FT                   /db_xref="UniProtKB/Swiss-Prot:P72001"
FT                   /protein_id="CAB09329.1"
FT                   /translation="MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALK
FT                   LMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAM
FT                   LRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASA
FT                   TTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSV
FT                   MGAHINQAIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQD
FT                   RATDILRRSQVAKLPVPSTHPVSPGTRWPQPTPWAGGAPPWGPPSSPLPRSARQPWLWV
FT                   GVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGVFVGSSVAPT
FT                   TIDIFNEPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAA
FT                   SYCVAGQNDPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQTVGAEPTAISCIKS
FT                   GADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG"
FT   misc_feature    237810..237881
FT                   /note="PS00107 Protein kinases ATP-binding region
FT                   signature"
FT   CDS             complement(239732..240133)
FT                   /transl_table=11
FT                   /locus_tag="Rv1744c"
FT                   /product="PROBABLE MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1744c, (MTCY28.06c), len: 133 aa. Probable
FT                   membrane protein, contains four imperfect 10 aa repeats,
FT                   some similarity to Q25946 (MSA-2) (FRAGMENT) from
FT                   Plasmodium falciparum (205 aa), FASTA scores: opt: 145, E(
FT                   ): 0.048, (52.4% identity in 63 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O06787"
FT                   /protein_id="CAB09330.1"
FT                   /translation="MVINRSIASIDSIAVAGSAATTGAVAVAGSVATAGSVAVAGSVAT
FT                   AGSVAIAGAAATAGSVGIIGSLLTVLCVAVRQCVACLACITCTRCVACIGCVRCTDCVG
FT                   CLWCVNCSGLRNVVGARNLRVGNLGRVSN"
FT   CDS             complement(240123..240734)
FT                   /transl_table=11
FT                   /gene="idi"
FT                   /locus_tag="Rv1745c"
FT                   /product="Probable isopentenyl-diphosphate delta-isomerase
FT                   IDI (IPP isomerase) (Isopentenyl pyrophosphate isomerase)"
FT                   /function="CATALYZES THE 1,3-ALLYLIC REARRANGEMENT OF THE
FT                   HOMOALLYLIC SUBSTRATE ISOPENTEN TO ITS ALLYLIC ISOMER,
FT                   DIMETHYLALLYL DIPHOSPHATE (DMAPP) [CATALYTIC ACTIVITY
FT                   :ISOPENTENYL DIPHOSPHATE = DIMETHYLALLYL DIPHOSPHATE]"
FT                   /EC_number="5.3.3.2"
FT                   /note="Rv1745c, (MTCY28.08c,MTCY04C12.29c), len: 203 aa.
FT                   Probable idi, isopentenyl-diphosphate delta-isomerase (EC
FT                   5.3.3.2), similar to Q46822|ORF_O182 from Escherichia coli
FT                   (182 aa), FASTA scores: opt: 465, E(): 4.7e-25, (46.9%
FT                   identity in 162 aa overlap), and to IPPI_SCHPO|Q10132
FT                   isopentenyl-diphosphate delta-isomerase from
FT                   Schizosaccharomyces pombe (227 aa), FASTA scores: opt: 185,
FT                   E(): 5.4e-06, (30.3% identity in 152 aa overlap). BELONGS
FT                   TO THE IPP ISOMERASE TYPE 1 FAMILY."
FT                   /db_xref="GOA:P72002"
FT                   /db_xref="HSSP:1NFZ"
FT                   /db_xref="InterPro:IPR000086"
FT                   /db_xref="UniProtKB/Swiss-Prot:P72002"
FT                   /protein_id="CAB09331.1"
FT                   /translation="MTRSYRPAPPIERVVLLNDRGDATGVADKATVHTGDTPLHLAFSS
FT                   YVFDLHDQLLITRRAATKRTWPAVWTNSCCGHPLPGESLPGAIRRRLAAELGLTPDRVD
FT                   LILPGFRYRAAMADGTVENEICPVYRVQVDQQPRPNSDEVDAIRWLSWEQFVRDVTAGV
FT                   IAPVSPWCRSQLGYLTKLGPCPAQWPVADDCRLPKAAHGN"
FT   CDS             240881..242311
FT                   /transl_table=11
FT                   /gene="pknF"
FT                   /locus_tag="Rv1746"
FT                   /product="ANCHORED-MEMBRANE SERINE/THREONINE-PROTEIN KINASE
FT                   PKNF (PROTEIN KINASE F) (STPK F)"
FT                   /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA
FT                   PHOSPHORYLATION). THOUGHT TO BE INVOLVED IN MEMBRANE
FT                   TRANSPORT. PHOSPHORYLATES THE PEPTIDE SUBSTRATE MYELIN
FT                   BASIC PROTEIN (MBP) AT SERINE AND THREONINE RESIDUES
FT                   [CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A
FT                   PHOSPHOPROTEIN]."
FT                   /EC_number="2.7.1.-"
FT                   /note="Rv1746, (MTCY28.09, MTCY04C12.30), len: 476 aa.
FT                   pknF, transmembrane serine/threonine-protein kinase (EC
FT                   2.7.1.-) (see citations below), highly similar to
FT                   KY28_MYCTU|Q10697 probable serine/threonine-protein kinase
FT                   from Mycobacterium tuberculosis (589 aa), FASTA scores:
FT                   opt: 870, E(): 0, (41.6% identity in 406 aa overlap).
FT                   Contains PS00108 Serine/Threonine protein kinases
FT                   active-site signature. Contains Hank's kinase subdomain.
FT                   BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.
FT                   Experimental studies show evidence of auto-phosphorylation.
FT                   Start site chosen by homology, may extend further
FT                   upstream."
FT                   /db_xref="GOA:P72003"
FT                   /db_xref="HSSP:1O6Y"
FT                   /db_xref="InterPro:IPR008271"
FT                   /db_xref="UniProtKB/Swiss-Prot:P72003"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09332.1"
FT                   /translation="MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRA
FT                   DVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDR
FT                   YPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADFGIA
FT                   GWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPFQHAN
FT                   PAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGHRLGGA
FT                   GDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVAVREFQRADDERAAQP
FT                   ARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALCFPLGSTG
FT                   TTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESPIRVCMQQT
FT                   GQTRRECREEIRRSNGWP"
FT   misc_feature    241277..241315
FT                   /note="PS00108 Serine/Threonine protein kinases active-site
FT                   signature"
FT   CDS             242373..244970
FT                   /transl_table=11
FT                   /locus_tag="Rv1747"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE ATP-BINDING
FT                   PROTEIN ABC TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT                   UNDETERMINATED SUBSTRATE (POSSIBLY LIPOOLIGOSACCHARIDE)
FT                   ACROSS THE MEMBRANE. RESPONSIBLE FOR ENERGY COUPLING TO THE
FT                   TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE SUBSTRATE
FT                   ACROSS THE MEMBRANE."
FT                   /note="Rv1747, (MTCY28.10, MTCY04C12.31), len: 865 aa.
FT                   Probable conserved transmembrane ATP-binding protein ABC
FT                   transporter (see citation below), similar to others e.g
FT                   Q55956 ABC transporter from Synechocystis sp. (790 aa),
FT                   FASTA scores: opt: 738, E(): 6.3e-26, (31.6% identity in
FT                   632 aa overlap); etc. Also similar to other M. tuberculosis
FT                   ABC-type transporters e.g. Rv2397c|MTCY253.24, FASTA score:
FT                   (35.2% identity in 213 aa overlap). Contains PS00017
FT                   ATP/GTP-binding site motif A (P-loop), and PS00211 ABC
FT                   transporters family signature. BELONGS TO THE ATP-BINDING
FT                   TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)."
FT                   /db_xref="GOA:O65934"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="UniProtKB/TrEMBL:O65934"
FT                   /protein_id="CAB09333.1"
FT                   /translation="MPMSQPAAPPVLTVRYEGSERTFAAGHDVVVGRDLRADVRVAHPL
FT                   ISRAHLLLRFDQGRWVAIDNGSLNGLYLNNRRVPVVDIYDAQRVHIGNPDGPALDFEVG
FT                   RHRGSAGRPPQTTSIRLPNLSAGAWPTDGPPQTGTLGSGQLQQLPPATTRIPAAPPSGP
FT                   QPRYPTGGQQLWPPSGPQRAPQIYRPPTAAPPPAGARGGTEAGNLATSMMKILRPGRLT
FT                   GELPPGAVRIGRANDNDIVIPEVLASRHHATLVPTPGGTEIRDNRSINGTFVNGARVDA
FT                   ALLHDGDVVTIGNIDLVFADGTLARREENLLETRVGGLDVRGVTWTIDGDKTLLDGISL
FT                   TARPGMLTAVIGPSGAGKSTLARLVAGYTHPTDGTVTFEGHNVHAEYASLRSRIGMVPQ
FT                   DDVVHGQLTVKHALMYAAELRLPPDTTKDDRTQVVARVLEELEMSKHIDTRVDKLSGGQ
FT                   RKRASVALELLTGPSLLILDEPTSGLDPALDRQVMTMLRQLADAGRVVLVVTHSLTYLD
FT                   VCDQVLLLAPGGKTAFCGPPTQIGPVMGTTNWADIFSTVADDPDAAKARYLARTGPTPP
FT                   PPPVEQPAELGDPAHTSLFRQFSTIARRQLRLIVSDRGYFVFLALLPFIMGALSMSVPG
FT                   DVGFGFPNPMGDAPNEPGQILVLLNVGAVFMGTALTIRDLIGERAIFRREQAVGLSTTA
FT                   YLIAKVCVYTVLAVVQSAIVTVIVLVGKGGPTQGAVALSKPDLELFVDVAVTCVASAML
FT                   GLALSAIAKSNEQIMPLLVVAVMSQLVFSGGMIPVTGRVPLDQMSWVTPARWGFAASAA
FT                   TVDLIKLVPGPLTPKDSHWHHTASAWWFDMAMLVALSVIYVGFVRWKIRLKAC"
FT   misc_feature    243426..243449
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   misc_feature    243732..243776
FT                   /note="PS00211 ABC transporters family signature"
FT   CDS             245343..246074
FT                   /transl_table=11
FT                   /locus_tag="Rv1748"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1748, (MTCY28.11, MTCY04C12.32), len: 243 aa.
FT                   Hypothetical unknown protein. Possibly exported protein,
FT                   hydrophobic domain, TM helix aa 23-45."
FT                   /db_xref="UniProtKB/TrEMBL:P72005"
FT                   /protein_id="CAB09334.1"
FT                   /translation="MPGGVCSGRPWGRPWWHPGLVGLLIRLAELLVVMLPLIGVLYVGI
FT                   KALSSFTRRLGEASGDLASDSPAMPRPTTVENDAARWRAITRAVEAHERTDARWLEYEL
FT                   DAAKLLDFPVMTDMRDPLTTAFHKAKLQADFHKPLRAEDLLDDPDAAGHYLDAVRDYVT
FT                   AFDTAEAEAMRRRRTGFSREEQQRLARAQSLLRVASDAGATAQERERAYRLARTELDGL
FT                   IVLPDRTRAGIERGIAGELDD"
FT   CDS             complement(246071..246628)
FT                   /transl_table=11
FT                   /locus_tag="Rv1749c"
FT                   /product="POSSIBLE INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1749c, (MTCY28.12c-MTCY04C12.33c), len: 185 aa.
FT                   Possible integral membrane protein, similar to
FT                   O27914|AE000940 hypothetical protein MTH1892 from
FT                   Methanobacterium thermoautotrophicum (168 aa), fasta
FT                   scores: E(): 9.3e-16, (37.4% identity in 123 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O65935"
FT                   /protein_id="CAB09335.1"
FT                   /translation="MLRAVNEIRQHDGTLKLGKGVGMFTIVGVIVALIGAFVQSRRHRH
FT                   RPAADIHMLWWMVLIVGVVSIIGAGYHVFDGERTAELIGYTRGDGGFQWENAMGDLAIG
FT                   VVGLMAYRFRGHFWLATIVVLTIQYVGDAAGHIYYWVVENNTNPYNIGVPLWTDILLPI
FT                   VMWALYAWSWHSNGDAVPKGQP"
FT   CDS             complement(246712..248310)
FT                   /transl_table=11
FT                   /gene="fadD1"
FT                   /locus_tag="Rv1750c"
FT                   /product="POSSIBLE FATTY-ACID-CoA LIGASE FADD1
FT                   (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)"
FT                   /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID
FT                   DEGRADATION."
FT                   /EC_number="6.2.1.-"
FT                   /note="Rv1750c, (MTCY28.13c, MTCY04C12.34), len: 532 aa.
FT                   Possible fadD1, fatty-acid-CoA synthetase (EC 6.2.1.-),
FT                   similar in part to others e.g. O35488|VLCS_MOUSE
FT                   VERY-LONG-CHAIN ACYL-CoA SYNTHETASE from Mus musculus (620
FT                   aa); NP_113924.1|NM_031736 solute carrier family 27 (fatty
FT                   acid transporter) member 2 from Rattus norvegicus (620 aa);
FT                   NP_459076.1|NC_003197 crotonobetaine/carnitine-CoA ligase
FT                   from Salmonella typhimurium (517 aa); CAIC_ECOLI|P31552
FT                   probable crotonobetaine/carnitine-coa ligase from
FT                   Escherichia coli (522 aa), FASTA scores: opt: 448, E():
FT                   1.9e-21, (25.1% identity in 502 aa overlap); etc. Also
FT                   highly similar to fadD17|Rv3506|MTV023.13 PROBABLE
FT                   FATTY-ACID-CoA LIGASE from Mycobacterium tuberculosis (502
FT                   aa); and similar to others from Mycobacterium tuberculosis
FT                   e.g. fadD6|MTCI364.18|Rv1206|O05307 PROBABLE FATTY-ACID-COA
FT                   LIGASE (597 aa), FASTA score: (28.3% identity in 519 aa
FT                   overlap); etc. Contains PS00455 Putative AMP-binding domain
FT                   signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME
FT                   FAMILY."
FT                   /db_xref="GOA:P72007"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="UniProtKB/TrEMBL:P72007"
FT                   /protein_id="CAB09316.1"
FT                   /translation="MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALIT
FT                   IADPQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRADCQIVV
FT                   TDADHRALLDGLDLAGARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSGTSG
FT                   NPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGAAIAP
FT                   ATFSATGFLDDVRRYHATYMNYVGKPLAYILATPERDDDADNPLRVAFGNEANDKDIEE
FT                   FSRRFGVQVEDGFGSTENAVIVIREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAH
FT                   GALTNADEAIGELVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAG
FT                   RTADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRAGDTFDP
FT                   DAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDEGTAVGKADTLWVREP
FT                   RGSAYHHASGPAKAI"
FT   misc_feature    complement(247813..247848)
FT                   /note="PS00455 Putative AMP-binding domain signature"
FT   CDS             248364..249746
FT                   /transl_table=11
FT                   /locus_tag="Rv1751"
FT                   /product="PROBABLE OXIDOREDUCTASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM"
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv1751, (MTCY28.14-MTCY04C12.35), len: 460 aa.
FT                   Probable oxidoreductase (EC 1.-.-.-), possibly a
FT                   monooxygenase or hydroxylase, similar to MHPA_ECOLI|P77397
FT                   3-(3-hydroxy-phenyl) propionate hydroxylase (554 aa), FASTA
FT                   scores: opt: 239, E(): 2e-08, (24.6% identity in 435 aa
FT                   overlap); and AJ007932|SAR7932.13 oxygenase from
FT                   Streptomyces argillaceus (436 aa), FASTA scores: opt: 587,
FT                   E(): 8.6e-30, (32.3% identity in 359 aa overlap). Contains
FT                   PS00075 Dihydrofolate reductase signature. Also similar to
FT                   Mycobacterium tuberculosis hypothetical oxidoreductases
FT                   Rv1260 and Rv0575c."
FT                   /db_xref="GOA:O65936"
FT                   /db_xref="InterPro:IPR003042"
FT                   /db_xref="UniProtKB/TrEMBL:O65936"
FT                   /protein_id="CAB09317.1"
FT                   /translation="MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYA
FT                   RALMGETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTTMRLL
FT                   DELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVAMVPQWDLLNLLAEA
FT                   AQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEGPGELRAELTVACDGRWSIARHEAG
FT                   LKAREFPVNFDVWWFKLPREGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQ
FT                   LRERGIEEFRRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
FT                   AMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAVTQAVQRVL
FT                   HRRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGVRPEHAPAFARRGPGNRK
FT                   GP"
FT   misc_feature    249621..249647
FT                   /note="PS00075 Dihydrofolate reductase signature"
FT   CDS             249873..250322
FT                   /transl_table=11
FT                   /locus_tag="Rv1752"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1752, (MTCY28.15), len: 149 aa. Conserved
FT                   hypothetical protein, similar to C-terminal half of
FT                   Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase (EC
FT                   1.3.1.20) from Canis familiaris (335 aa), FASTA score, opt:
FT                   168, E(): 0.00015, (31.3% identity in 112 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O06789"
FT                   /protein_id="CAB09318.1"
FT                   /translation="MDAGCYAVHMAHTFGGATPEVVSAQAKLRDPAVDRAMTAELKFPG
FT                   GHTGGIRCSMRSSDLLNVSARVVGDRGELRVLNPVVPQLFHRLPPLACVSARRFRCRSA
FT                   ARASGQDDAQGRGREHERDPRDLSGRRAPIAQPELNMVAASGSAA"
FT   CDS             complement(250357..253518)
FT                   /transl_table=11
FT                   /gene="PPE24"
FT                   /locus_tag="Rv1753c"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1753c, (MTCY28.16c), len: 1053 aa. Member of the
FT                   Mycobacterium tuberculosis PPE family of Gly-, Asn-rich
FT                   proteins, similar to many e.g. YF48_MYCTU|Q10778
FT                   hypothetical protein cy48.17 (678 aa), FASTA scores: opt:
FT                   1360, E(): 0, (48.9% identity in 550 aa overlap). Note that
FT                   the Gly-, Asn-rich sequence is interrupted by six
FT                   near-perfect 26 aa repeats, a unique region, and another,
FT                   more degenerate region of five 25 aa repeats before
FT                   resuming at the C-terminus. The end of the first Gly-, Asn-
FT                   rich region and the start of the first set of repeats shows
FT                   some similarity to Q50577|AT10S from Mycobacterium
FT                   tuberculosis (170 aa) (40.2% identity in 189 aa overlap)."
FT                   /db_xref="InterPro:IPR002989"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q79FL2"
FT                   /protein_id="CAE55416.1"
FT                   /translation="MNFSVLPPEINSALIFAGAGPEPMAAAATAWDGLAMELASAAASF
FT                   GSVTSGLVGGAWQGASSSAMAAAAAPYAAWLAAAAVQAEQTAAQAAAMIAEFEAVKTAV
FT                   VQPMLVAANRADLVSLVMSNLFGQNAPAIAAIEATYEQMWAADVSAMSAYHAGASAIAS
FT                   ALSPFSKPLQNLAGLPAWLASGAPAAAMTAAAGIPALAGGPTAINLGIANVGGGNVGNA
FT                   NNGLANIGNANLGNYNFGSGNFGNSNIGSASLGNNNIGFGNLGSNNVGVGNLGNLNTGF
FT                   ANTGLGNFGFGNTGNNNIGIGLTGNNQIGIGGLNSGTGNFGLFNSGSGNVGFFNSGNGN
FT                   FGIGNSGNFNTGGWNSGHGNTGFFNAGSFNTGMLDVGNANTGSLNTGSYNMGDFNPGSS
FT                   NTGTFNTGNANTGFLNAGNINTGVFNIGHMNNGLFNTGDMNNGVFYRGVGQGSLQFSIT
FT                   TPDLTLPPLQIPGISVPAFSLPAITLPSLNIPAATTPANITVGAFSLPGLTLPSLNIPA
FT                   ATTPANITVGAFSLPGLTLPSLNIPAATTPANITVGAFSLPGLTLPSLNIPAATTPANI
FT                   TVGAFSLPGLTLPSLNIPAATTPANITVGAFSLPGLTLPSLNIPAATTPANITVSGFQL
FT                   PPLSIPSVAIPPVTVPPITVGAFNLPPLQIPEVTIPQLTIPAGITIGGFSLPAIHTQPI
FT                   TVGQIGVGQFGLPSIGWDVFLSTPRITVPAFGIPFTLQFQTNVPALQPPGGGLSTFTNG
FT                   ALIFGEFDLPQLVVHPYTLTGPIVIGSFFLPAFNIPGIDVPAINVDGFTLPQITTPAIT
FT                   TPEFAIPPIGVGGFTLPQITTQEIITPELTINSIGVGGFTLPQITTPPITTPPLTIDPI
FT                   NLTGFTLPQITTPPITTPPLTIDPINLTGFTLPQITTPPITTPPLTIEPIGVGGFTTPP
FT                   LTVPGIHLPSTTIGAFAIPGGPGYFNSSTAPSSGFFNSGAGGNSGFGNNGSGLSGWFNT
FT                   NPAGLLGGSGYQNFGGLSSGFSNLGSGVSGFANRGILPFSVASVVSGFANIGTNLAGFF
FT                   QGTTS"
FT   repeat_region   complement(251630..251707)
FT                   /note="78 bp imperfect direct repeat 6,
FT                   CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCAC
FT                   CACACCCGCCAACATCACCGT"
FT   repeat_region   complement(251708..251785)
FT                   /note="78 bp imperfect direct repeat 5,
FT                   CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCAC
FT                   CACACCAGCCAACATCACCGT"
FT   repeat_region   complement(251786..251863)
FT                   /note="78 bp imperfect direct repeat 4,
FT                   CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCAC
FT                   CACACCAGCCAACATCACCGT"
FT   repeat_region   complement(251864..251941)
FT                   /note="78 bp imperfect direct repeat 3,
FT                   GGGTGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCAC
FT                   CACACCAGCCAACATCACCGT"
FT   repeat_region   complement(251942..252019)
FT                   /note="78 bp imperfect direct repeat 2,
FT                   CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCAC
FT                   CACACCAGCCAACATCACCGT"
FT   repeat_region   complement(252020..252097)
FT                   /note="78 bp imperfect direct repeat 1,
FT                   TCCCGCCTTCAGTCTGCCGGCAATAACGCTGCCGTCGCTGAACATCCCGGCCGCCAC
FT                   CACACCGGCCAACATCACCGT"
FT   CDS             complement(253722..255413)
FT                   /transl_table=11
FT                   /locus_tag="Rv1754c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1754c, (MTCY28.17c), len: 563 aa. Conserved
FT                   hypothetical protein, has proline-rich central region. Some
FT                   similarity in central region to other Mycobacterium
FT                   tuberculosis proline-rich proteins e.g.
FT                   O06555|Rv1157c|MTCI65.24c (371 aa), (32.5% identity in 191
FT                   aa overlap). Contains PS00017 ATP/GTP-binding site motif A
FT                   (P-loop)."
FT                   /db_xref="UniProtKB/TrEMBL:O06790"
FT                   /protein_id="CAB09320.1"
FT                   /translation="MYRYQVRVQQRRSEMNRWVATRSRRHTYQWITDHKSPRDHYRHIS
FT                   ELRTSIATSSPGRCDMSPIPRIVSVSLAWAAAIGLMVPIGLAPPAMAAPCSGDAANAPP
FT                   PPSAIVTDPGATALGPVRPGHGPIPTGRKPRGANDRAPLPKLGPLISALLNPGARNAAP
FT                   LQQQALVPRANPGPNPAPNPPATGPQPPNATQLTPNPAPAPDPAPAAAPDPGATLAGAT
FT                   TSLAEWVTGPDSPNKTLERFGISGTDLGIPWDNGDPANRQVLMIFGDTFGYCAVDGHQW
FT                   RYNTLFRSQDRDLGNGVHVTSGDASNRYSGSPVRQPGFSKQLINSIKWARDETGIIPTA
FT                   GIAVGKTQYVNFMSIRNWGRDGEWTTNYSGIAVSKDNGQTWGVFPGTIRASGPDSGGKA
FT                   RFVPGNENFQMGAYLKSNDGYLYSFGTPPGRGGSAYLARVPQRFVPDLTKYQYWNGDSN
FT                   SWVPNKPDAATPVIPGPVGEMSVQYNTYLKQYLALYTNGMNDVVARTAPAPQGPWSAEQ
FT                   MLVSSWQMPGGIYAPMMHPWSTGKDVYFNLSLWSAYNVMLMHTVLP"
FT   misc_feature    complement(254373..254396)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             complement(255597..>256439)
FT                   /transl_table=11
FT                   /gene="plcD"
FT                   /locus_tag="Rv1755c"
FT                   /product="PROBABLE PHOSPHOLIPASE C 4 (FRAGMENT) PLCD"
FT                   /function="HYDROLYZES SPHINGOMYELIN IN ADDITION TO
FT                   PHOSPHATIDYLCHOLINE. PROBABLE VIRULENCE FACTOR IMPLICATED
FT                   IN THE PATHOGENESIS OF M.TUBERCULOSIS AT THE LEVEL OF
FT                   INTRACELLULAR SURVIVAL, BY THE ALTERATION OF CELL SIGNALING
FT                   EVENTS OR BY DIRECT CYTOTOXICITY [CATALYTIC ACTIVITY: A
FT                   PHOSPHATIDYLCHOLINE + H(2)O = 1,2- DIACYLGLYCEROL + CHOLINE
FT                   PHOSPHATE]."
FT                   /EC_number="3.1.4.3"
FT                   /note="Rv1755c, (MT1799, MTCY28.21c), len: 280 aa. Probable
FT                   plcD, phospholipase C 4 (fragment) (EC 3.1.4.3) (see
FT                   citations below), highly similar to C-terminus of other
FT                   phospholipases e.g.
FT                   CQ50771|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase
FT                   C 1 from Mycobacterium tuberculosis (512 aa), FASTA score:
FT                   (71.1% identity in 284 aa overlap); etc. Note that this ORF
FT                   has been interrupted by insertion of IS6110 element.
FT                   BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY."
FT                   /db_xref="GOA:P0A5R8"
FT                   /db_xref="InterPro:IPR017909"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5R8"
FT                   /protein_id="CAB09340.1"
FT                   /translation="DAGVSWKVYRNKTLGPISSVLTYGSLVTSFKQSADPRSDLVRFGV
FT                   APSYPASFAADVLANRLPRVSWVIPNVLESEHPAVPAAAGAFAIVNILRILLANPAVWE
FT                   KTALIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLGFRVPCF
FT                   VISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVTGDMTSTFNFAVPPNS
FT                   SWPNLDYPGLHALSTVPQCVPNAALGTINRGIPYRVPDPQIMPTQETTPTRGIPSGPC"
FT   repeat_region   256446..256473
FT                   /note="28 bp inverted repeat at the left end of IS6110,
FT                   TGAACCGCCCCGGTGAGTCCGGAGACTC."
FT   repeat_region   complement(256446..257800)
FT                   /mobile_element="insertion sequence:IS6110-3"
FT                   /note="IS6110-3, len: 1355 bp. Insertion sequence IS6110."
FT   CDS             complement(256488..257372)
FT                   /transl_table=11
FT                   /locus_tag="Rv1756c"
FT                   /product="PUTATIVE TRANSPOSASE"
FT                   /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION
FT                   ELEMENT IS6110."
FT                   /note="Rv1756c, (MTCY28.22c), len: 294 aa. Putative
FT                   Transposase subunit for IS6110."
FT                   /db_xref="GOA:P0C5G8"
FT                   /db_xref="InterPro:IPR001584"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0C5G8"
FT                   /protein_id="CAB09336.1"
FT                   /translation="MRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEH
FT                   ISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPA
FT                   TARPADLVQRRFGPPAPNRLWVADLT