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EBI DbfetchID BX842576; SV 1; linear; genomic DNA; STD; PRO; 348264 BP. XX AC BX842576; AL021006; AL021184; AL022000; Z73419; Z73902; Z75555; Z77137; AC Z77164; Z77826; Z79701; Z80108; Z81011; Z83862; Z95844; XX DT 21-NOV-2003 (Rel. 77, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 5/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-348264 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF01118; PK-G12rRNA. DR SILVA-LSU; BX842576. DR SILVA-SSU; BX842576. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..348264 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT CDS 170..1159 FT /transl_table=11 FT /gene="mdh" FT /locus_tag="Rv1240" FT /product="PROBABLE MALATE DEHYDROGENASE MDH" FT /function="INVOLVED IN THE CONVERSION OF MALATE TO FT OXALOACETATE [CATALYTIC ACTIVITY: (S)-malate + NAD+ = FT oxaloacetate + NADH]." FT /EC_number="1.1.1.37" FT /note="Rv1240, (MTV006.12), len: 329 aa. Probable mdh, FT Malate dehydrogenase (EC 1.1.1.37). Most similar to FT P50917|MDH_MYCLE MALATE DEHYDROGENASE from Mycobacterium FT leprae (329 aa), FASTA scores: opt: 1887, E(): 0, (89.1% FT identity in 329 aa overlap). Contains PS00068 Malate FT dehydrogenase active site signature. BELONGS TO THE LDH FT FAMILY. MDH SUBFAMILY. TBparse score is 0.867." FT /db_xref="GOA:P0A5J6" FT /db_xref="HSSP:1BDM" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P0A5J6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA15896.1" FT /translation="MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIE FT PALQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDLLE FT ANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNR FT AISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIEDEFIP FT TVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLI FT SSFPVTTKGGNWTIVSGLEIDEFSRGRIDKSTAELADERSAVTELGLI" FT misc_feature 635..673 FT /note="PS00068 Malate dehydrogenase active site signature" FT CDS 1235..1495 FT /transl_table=11 FT /locus_tag="Rv1241" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1241, (MTV006.13), len: 86 aa. Conserved FT hypothetical protein, member of family of 16 hypothetical FT Mycobacterium tuberculosis proteins including: FT Rv2871|Q10799|YS71_MYCTU HYPOTHETICAL 13.2 kDa PROTEIN CY2 FT (124 aa), FASTA scores: opt: 172, E(): 9.5e-06, (37.2% FT identity in 86 aa overlap); Rv2132, Rv3321c, etc. TBparse FT score is 0.875." FT /db_xref="UniProtKB/TrEMBL:O50456" FT /protein_id="CAA15897.1" FT /translation="MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQ FT EQYRLEPHESAVRSGLDLAGFNKLADELEDEALLDATRRAR" FT CDS 1492..1923 FT /transl_table=11 FT /locus_tag="Rv1242" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1242, (MTV006.14), len: 143 aa. Conserved FT hypothetical protein, member of family of 14 hypothetical FT Mycobacterium tuberculosis proteins including: FT Rv2872|Q10800|YS72_MYCTU (147 aa), FASTA scores: opt: 226, FT E(): 2.7e-09, (32.1% identity in 137 aa overlap); Rv0749, FT Rv0277c, Rv2530c, etc. TBparse score is 0.893." FT /db_xref="InterPro:IPR006226" FT /db_xref="UniProtKB/TrEMBL:O50457" FT /protein_id="CAA15898.1" FT /translation="MIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALF FT GFLRIATSARVLAAPLPTADAIAYVREWLSQPNVDLLTAGPRHLDIALGLLDKLGTASH FT LTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE" FT CDS complement(1946..3634) FT /transl_table=11 FT /gene="PE_PGRS23" FT /locus_tag="Rv1243c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1243c, (MTV006.15c), len: 562 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see Brennan & Delogu 2002). TBparse FT score is 0.875." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FQ7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55374.1" FT /translation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transl_table=11 FT /gene="lpqZ" FT /locus_tag="Rv1244" FT /product="PROBABLE LIPOPROTEIN LPQZ" FT /function="UNKNOWN" FT /note="Rv1244, (MTV006.16), len: 286 aa. Probable FT lipoprotein lpqZ, equivalent toU15180|MLU1518042 protein FT u1756x from Mycobacterium leprae (228 aa), FASTA scores: FT opt: 1039, E(): 0, (72.5% identity in 229 aa overlap). FT Similar to Mycobacterium tuberculosis hypothetical protein FT Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein FT lipid attachment site. TBparse score is 0.878." FT /db_xref="GOA:O50459" FT /db_xref="InterPro:IPR007210" FT /db_xref="UniProtKB/TrEMBL:O50459" FT /protein_id="CAA15900.1" FT /translation="MRITRILALLLAVLLAVSGVAGCSADTGDRHPELVVGSTPDSEAM FT LLAAIYVAALRSYGFAAHAETAADPVAKLDSGAFTVVPAFTGQMLQTLQPDASVRSDAQ FT VYRAIVSALPEGIAAGDYTTAAEDKPALVVTQSTAKAWGGGDLSELPSHCRGLLVGRVA FT GAHTPAAVGPCRLPAPREFRNDATMFAALRAGQLVAAWTTTADPDIPADLIMLTDGKPA FT LIRAENIVPLYRRNALTERQLLAVNEVAGVLDTTALIGMRRQVAAGADPAAVAAGWLAE FT HPLGR" FT misc_feature 3850..3882 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(4755..5585) FT /transl_table=11 FT /locus_tag="Rv1245c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; SUPPOSED INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv1245c, (MTV006.17c), len: 276 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), FT equivalent to NP_301801.1|NC_002677 short chain alcohol FT dehydrogenase from Mycobacterium leprae (277 aa). Also FT highly similar to various dehydrogenases and FT oxidoreductases e.g. NP_250228.1|NC_002516 probable FT short-chain dehydrogenase from Pseudomonas aeruginosa (295 FT aa); NP_421969.1|NC_002696 short chain dehydrogenase family FT protein from Caulobacter crescentus (278 aa); etc. Also FT highly similar to others from Mycobacterium tuberculosis FT e.g. Rv3085|MTV013.06 PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE (276 aa), FASTA scores: opt: 368, FT E(): 1.2e-16, (35.3% identity in 224 aa overlap); FT Rv3057c|MTCY22D7.24 PUTATIVE SHORT CHAIN ALCOHOL FT DEHYDROGENASE/REDUCTASE (287 aa), FASTA scores: opt: 471, FT E(): 1.3e-21, (32.4% identity in 281 aa overlap); etc. FT Contains PS00061 Short-chain dehydrogenases/reductases FT family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is FT 0.871." FT /db_xref="GOA:O50460" FT /db_xref="HSSP:1A27" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O50460" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA15901.1" FT /translation="MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDGLAD FT TEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTGDIEVSQF FT KDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLFSAPGQAAYNSAKFAVR FT GFTEALRQEMALAGHPVKVTTVHPGGVKTAIARNATAAEGLDQAELAETFDKRVAHLSP FT QRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFPIITGRLIPRPR" FT misc_feature complement(5076..5162) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS complement(5642..5935) FT /transl_table=11 FT /locus_tag="Rv1246c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1246c, (MTV006.18c), len: 97 aa. Conserved FT hypothetical protein, highly similar to Rv2866|MTV003.12 FT hypothetical Mycobacterium tuberculosis protein (87 aa), FT FASTA scores: opt: 290, E(): 3.9e-24, (54.1% identity in 85 FT aa overlap)." FT /db_xref="InterPro:IPR007712" FT /db_xref="UniProtKB/TrEMBL:O50461" FT /protein_id="CAA15902.1" FT /translation="MSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRL FT GKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEIIHIARRSASYRMNPCRPR" FT CDS complement(5932..6201) FT /transl_table=11 FT /locus_tag="Rv1247c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1247c, (MTV006.19c), len: 89 aa. Conserved FT hypothetical protein, some similarity to hypothetical FT proteins including Mycobacterium tuberculosis proteins FT Rv2865|MTV003.11 (93 aa), FASTA scores: opt: 249, E(): FT 5.4e-13, (44.2% identity in 86 aa overlap); FT Rv0268|Z86089|P95225 (169 aa) opt: 125, E(): 0.0089, (41.8% FT identity in 55 aa overlap); etc. and Escherichia coli FT AE000293|ECAE0002933 (92 aa), FASTA scores: opt: 127, E(): FT 0.0038, (29.3% identity in 82 aa overlap). TBparse score is FT 0.905." FT /db_xref="InterPro:IPR006442" FT /db_xref="UniProtKB/TrEMBL:O50462" FT /protein_id="CAA15903.1" FT /translation="MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDL FT ASIEETLEVLRTPGASEAIREGLADVAAGRFVSNDEIRNRYTAR" FT CDS complement(6314..9958) FT /transl_table=11 FT /gene="sucA" FT /locus_tag="Rv1248c" FT /product="PROBABLE 2-OXOGLUTARATE DEHYDROGENASE SUCA FT (Alpha-ketoglutarate dehydrogenase)" FT /function="THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX FT CATALYZES THE OVERALL CONVERSION OF 2-OXOGLUTARATE TO FT SUCCINYL-CoA & CO(2). IT CONTAINS MULTIPLE COPIES OF 3 FT ENZYMATIC COMPONENTS:2-OXOGLUTARATE DEHYDROGENASE (E1), FT DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE (E2) AND LIPOAMIDE FT DEHYDROGENASE (E3) [CATALYTIC ACTIVITY: 2-oxoglutarate + FT lipoamide = S-succinyldihydrolipoamide + CO2]" FT /EC_number="1.2.4.2" FT /note="Rv1248c, (MTV006.20c), len: 1214 aa. Probable sucA, FT 2-oxoglutarate dehydrogenase (EC 1.2.4.2), highly similar FT to several but closest to D84102 Corynebacterium glutamicum FT (1257 aa), FASTA scores: opt: 4418, E(): 0, (59.4% identity FT in 1223 aa overlap). TBparse score is 0.882." FT /db_xref="GOA:O50463" FT /db_xref="HSSP:1E2O" FT /db_xref="InterPro:IPR001017" FT /db_xref="UniProtKB/Swiss-Prot:O50463" FT /protein_id="CAA15904.1" FT /translation="MYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAE FT RAAAAAPQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSAS FT LEVPTATSVRAVPAKLLIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRH FT YTEVDGKPTAVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRR FT ARDGKLTTEDFAGVTISLTNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEER FT IAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRW FT STDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWD FT LDRVFKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVK FT PTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDE FT VVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFG FT DNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAF FT AGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIF FT HVNGDDPEACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDT FT KRGARKSYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHGVQPSESVESDQ FT MIPAGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKIDWAFGELL FT ALGSLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKF FT LVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQL FT SNVVLLLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQ FT RPLIVFTPKSMLRHKAAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLY FT YELAARKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPR FT FGLELPELLPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFG" FT CDS complement(10151..10939) FT /transl_table=11 FT /locus_tag="Rv1249c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1249c, (MTV006.21c), len: 262 aa. Possible FT membrane protein. Start uncertain. TBparse score is 0.899." FT /db_xref="UniProtKB/TrEMBL:O50464" FT /protein_id="CAA15905.1" FT /translation="MSARRIRSWKRFDNRSANAAEPDPQLAGTGGRPKVSTRALAQVIE FT RSSRIQGPAAQAYVARLRRAHPGASPAKIVAKLEKRFLSVVTASGAAVGAAATLPGIGT FT LAAWFAAAGEVVVFLEATALFVLALASVHAIPLDHRERRRALVLAVLVGDNTTAVADLL FT GPGRTSGGWVSETMASLPLPAISSLNSRMLKYVVKRFALKRGALMFGKLVPMGIGAIIG FT AIGNRLVGKKLVRNARSAFGTPPARWPVTLHVLPTVRDAS" FT CDS 11136..12875 FT /transl_table=11 FT /locus_tag="Rv1250" FT /product="PROBABLE DRUG-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN" FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF DRUG FT ACROSS THE MEMBRANE (EXPORT): DRUG RESISTANCE BY AN EXPORT FT MECHANISM (CONFERES RESISTANCE TO TOXIC COMPOUNDS BY FT REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1250, (MTV006.22), len: 579 aa. Probable FT drug-transport integral membrane protein, member of major FT facilitator superfamily (MFS), highly similar to several FT including P39886|TCMA_STRGA TETRACENOMYCIN C RESISTANCE FT PROTEIN from Streptomyces glaucescens (538 aa), FASTA FT scores: opt: 847, E(): 0, (32.9% identity in 517 aa FT overlap); etc. Also similar to MTCY20B11.14c|Rv3239C from FT Mycobacterium tuberculosis (1048 aa), FASTA scores: opt: FT 629, E(): 6.7e-13, (31.9% identity in 423 aa overlap). FT TBparse score is 0.921." FT /db_xref="GOA:O50465" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:O50465" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA15906.1" FT /translation="MTTAIRRAAGSSYFRNPWPALWAMMVGFFMIMLDSTVVAIANPTI FT MAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYLIGLGVFTVASLGCGLS FT SGAGMLIAARVVQGVGAGLLTPQTLSTITRIFPAHRRGVALGAWGTVASVASLVGPLAG FT GALVDSMGWEWIFFVNVPVGVIGLILAAYLIPALPHHPHRFDWFGVGLSGAGMFLIVFG FT LQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNAREPLIPLEVFNDRNFSLSNLRIAI FT IAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAPFVGMIIDRSHPLCVLG FT FGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAFVWSPLTVTATRNLRPHLAGA FT SSGVFNAVRQLGAVLGSASMAAFMTSRIAAEMPGGVDALTGPAGQDATVLQLPEFVREP FT FAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAVAKEPLPESDGDADDDDYVEYILRRE FT PEEDCDTQPLRASRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRAWQADTESTAP FT SAL" FT CDS complement(12778..16197) FT /transl_table=11 FT /locus_tag="Rv1251c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1251c, (MTV006.23c), len: 1139 aa. Conserved FT hypothetical protein, showing some similarity in C-terminal FT region with other proteins from eukaryotes and bacteria FT e.g. NP_142121.1 hypothetical protein from Pyrococcus FT horikoshii (1188 aa); and some similarity to GTP-binding FT proteins e.g. P23249|MV10_MOUSE PUTATIVE GTP-BINDING FT PROTEIN (1004 aa), FASTA scores: opt: 228, E(): 1.7e-06, FT (27.7% identity in 560 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). TBparse score is FT 0.906." FT /db_xref="GOA:O50466" FT /db_xref="InterPro:IPR019993" FT /db_xref="UniProtKB/TrEMBL:O50466" FT /protein_id="CAA15907.1" FT /translation="MFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDEL FT MARAAVLGSAHEGRRLDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPVVY FT QAAMFDGRFVGFADFLIRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPVAAD FT AELELGDGTIVRYRVGELIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQC FT TERLRASDDLLLVGGMRVRQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLTAQAKL FT QIRQRDTGAPQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYLFGVLEA FT GRAGVFRPLWAHDRTAERQALTDFLAIVARRRRRHPNMHIYHYAPYEKTALLRLVGRYG FT IGEDDVDDLLRNGVLVDLYPLVRKSIRVGTDSFSLKALEPLYLGTQPRSGDVTTAADSI FT NSYARYCELRAAGRIDEAATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQP FT VPDADPIDDGDSLASVLSKFTGDAAAGERTPEQTAVALLAAARGYHRREDKPFWWAHFD FT RLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTGELARGDLNGNVFALY FT EPPAPPGMTDNPDRRAAGPAAVVETDDPTVPTEVVIVERTGSDGNTFQQLPFALAPGPP FT VPTTALRESIESTAAAVASGSPQLPSTALMDVLLRRPPRTRSGAALPRSSDPVTDIAAA FT ALDLDSSYLAVHGPPGTGKTYTAARVIAELVTEHAWRIGVVAQSHATVENLLEGVISAG FT LDPGQVAKKPHDHTAGRWQSIDGSQYTEFIRDTAGCVIGGTAWDFANGNRVPKASLDLL FT VIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPEPVDTSALSWLVDGQHTL FT PDERGYFLDRSYRMHPAVCAAVSALSYEGRLCSHTERTAVRRLDGYPPGVHTRGVHHKG FT NSIESPEEAEAILAELRQLLGSPWTDEHGTRPLAASDVLVLAPYNAQVALVRRRLASAG FT LGGADGVRVGTVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAA FT VIVRSELLTQYLPATPDGLVDLGAFLGLTSTS" FT misc_feature complement(13879..13902) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(16253..16861) FT /transl_table=11 FT /gene="lprE" FT /locus_tag="Rv1252c" FT /product="PROBABLE LIPOPROTEIN LPRE" FT /function="UNKNOWN" FT /note="Rv1252c, (MTCY50.30), len: 202 aa. Probable FT lipoprotein lprE, some similarity to Mycobacterium FT tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA FT scores: E(): 7e-05, (29.5% identity in 200 aa overlap). FT Contains possible N-terminal signal sequence and FT appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013)." FT /db_xref="GOA:P65312" FT /db_xref="UniProtKB/Swiss-Prot:P65312" FT /protein_id="CAB00900.1" FT /translation="MPGVWSPPCPTTPRVGVVAALVAATLTGCGSGDSTVAKTPEATPS FT LSTAHPAPPSSEPSPPSATAAPPSNHSAAPVDPCAVNLASPTIAKVVSELPRDPRSEQP FT WNPEPLAGNYNECAQLSAVVIKANTNAGNPTTRAVMFHLGKYIPQGVPDTYGFTGIDTS FT QCTGDTVALTYASGIGLNNVVKFRWNGGGVELIGNTTGG" FT CDS 16927..18618 FT /transl_table=11 FT /gene="deaD" FT /locus_tag="Rv1253" FT /product="PROBABLE COLD-SHOCK DEAD-BOX PROTEIN A HOMOLOG FT DEAD (ATP-dependent RNA helicase deaD homolog)" FT /function="HAS A HELIX-DESTABILIZING ACTIVITY" FT /note="Rv1253, (MTCY50.29c), len: 563 aa. Probable Dead, FT Cold-shock DEAD-box protein A homolog, similar to many e.g. FT DEAD_ECOLI|P23304 Escherichia coli (646 aa), FASTA scores: FT opt: 1490, E(): 0, (46.7% identity in 578 aa overlap); FT similar to Mycobacterium tuberculosis Rv3211. Contains FT PS00017 ATP/GTP-binding site motif A, PS00039 DEAD-box FT subfamily ATP-dependent helicases signature. BELONGS TO THE FT DEAD BOX FAMILY HELICASE." FT /db_xref="GOA:Q11039" FT /db_xref="HSSP:1QDE" FT /db_xref="InterPro:IPR014014" FT /db_xref="UniProtKB/Swiss-Prot:Q11039" FT /protein_id="CAB00899.1" FT /translation="MAFPEYSPAASAATFADLQIHPRVLRAIGDVGYESPTAIQAATIP FT ALMAGSDVVGLAQTGTGKTAAFAIPMLSKIDITSKVPQALVLVPTRELALQVAEAFGRY FT GAYLSQLNVLPIYGGSSYAVQLAGLRRGAQVVVGTPGRMIDHLERATLDLSRVDFLVLD FT EADEMLTMGFADDVERILSETPEYKQVALFSATMPPAIRKLSAKYLHDPFEVTCKAKTA FT VAENISQSYIQVARKMDALTRVLEVEPFEAMIVFVRTKQATEEIAEKLRARGFSAAAIS FT GDVPQAQRERTITALRDGDIDILVATDVAARGLDVERISHVLNYDIPHDTESYVHRIGR FT TGRAGRSGAALIFVSPRELHLLKAIEKATRQTLTEAQLPTVEDVNTQRVAKFADSITNA FT LGGPGIELFRRLVEEYEREHDVPMADIAAALAVQCRGGEAFLMAPDPPLSRRNRDQRRD FT RPQRPKRRPDLTTYRVAVGKRHKIGPGAIVGAIANEGGLHRSDFGQIRIGPDFSLVELP FT AKLPRATLKKLAQTRISGVLIDLRPYRPPDAARRHNGGKPRRKHVG" FT misc_feature 17095..17118 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 17407..17433 FT /note="PS00039 DEAD-box subfamily ATP-dependent helicases FT signature" FT CDS 18615..19766 FT /transl_table=11 FT /locus_tag="Rv1254" FT /product="PROBABLE ACYLTRANSFERASE" FT /function="CATALYZES THE ACYLATION OF THE MYCAMINOSE SUGAR FT DURING MIDECAMYCIN BIOSYNTHESIS" FT /EC_number="2.3.1.-" FT /note="Rv1254, (MTCY50.28c), len: 383 aa. Probable FT Acyltransferase (EC 2.3.1.-), similar to G927228 FT midecamycin 4-0-propionyl transferase (fragment) (388 aa), FT FASTA scores, opt: 305, E(): 5.6e-14, (28.4% identity in FT 377 aa overlap). Also similar to other Mycobacterium FT tuberculosis acyltransferases e.g. Rv0111, Rv0228, etc. FT Contains PS00881 Protein splicing signature." FT /db_xref="GOA:Q11064" FT /db_xref="InterPro:IPR002656" FT /db_xref="UniProtKB/TrEMBL:Q11064" FT /protein_id="CAB00898.1" FT /translation="MTLPKERAAQGGLERIAHVDRVASLTGIRAVAALLVVGTHAAYTT FT GKYTHGYWGLMSSRMEIGVPIFFVLSGFLLFRPWVKSAATGGPPPSLSRYAWHRVRRIM FT PAYTVTVLLAYLVYHFRTAGPNPGHTWVGLFRNLTLTQIYTDGYLGAFLHQGLTQMWSL FT AVEVAFYLALPALAYLLLVLVCRRRWQPRLLLATMAGLTMISPAWLILVHNTHWMPDGA FT RLWLPTYLAWFVGGMMLAVLAAMGVRCYAFVAIPLAVICYFIVSTPIAGAPTTSPTALA FT EALVKTAFYAVIAVLAVAPLALGDQGWYAQLLASRPMVFLGEISYEIFLIHLVTMEIAM FT VDVLGYRVYTSSMVNLCLVTLVLTIPLAWLLHRFTRVQGDRPS" FT misc_feature 19242..19259 FT /note="PS00881 Protein splicing signature" FT CDS complement(19735..20343) FT /transl_table=11 FT /locus_tag="Rv1255c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv1255c, (MTCY50.27), len: 202 aa. Possible FT regulatory protein, similar to others e.g. FT ACRR_ECOLI|P34000 potential acrab operon repressor from E. FT coli (215 aa), FASTA scores: opt: 128, E(): 0.25, (42.1% FT identity in 57 aa overlap). Helix turn helix motif present FT at aa 36-57 (+5.48 SD)." FT /db_xref="GOA:Q11063" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:Q11063" FT /protein_id="CAB00897.1" FT /translation="MAGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAG FT CSRATLYRYFDSREALRTAYVHRETRRLGREIMVKIADVVEPAERLLVSITTTLRMVRD FT NPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRMLTSL FT LMFPGRDEADERAMIAEFVVPIVTPASAAARKAGHPGPE" FT CDS complement(20343..21560) FT /transl_table=11 FT /gene="cyp130" FT /locus_tag="Rv1256c" FT /product="PROBA BLE CYTOCHROME P450 130 CYP130" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv1256c, (MT1295, MTCY50.26), len: 405 aa. Probable FT cyp130, cytochrome P450 (EC 1.14.-.-), similar to other FT cytochromes P-450 e.g. S51594 cytochrome P450 mycG from FT Micromonospora griseorubida (397 aa); T36526 probable FT cytochrome P450 hydroxylase from Streptomyces coelicolor FT (411 aa); CPXK_SACER|P33271|107B1 CYTOCHROME P450 from FT Saccharopolyspora erythraea (405 aa), FASTA scores: opt: FT 639, E(): 2.7e-33, (33.2% identity in 391 aa overlap); etc. FT Also similar to others from Mycobacterium tuberculosis e.g. FT Rv0766c|MTCY369.11c CYTOCHROME P450 (402 aa); etc. Contains FT PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:Q11062" FT /db_xref="InterPro:IPR017972" FT /db_xref="PDB:2UUQ" FT /db_xref="UniProtKB/Swiss-Prot:Q11062" FT /protein_id="CAB00896.1" FT /translation="MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEYD FT YYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLV FT SRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDW FT TQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVG FT ADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPDAVE FT ELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRC FT PRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSV FT PFRVTS" FT misc_feature complement(20493..20522) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(21674..23041) FT /transl_table=11 FT /locus_tag="Rv1257c" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.-.-.-" FT /note="Rv1257c, (MTCY50.25), len: 455 aa. Probable FT oxidoreductase (EC 1.-.-.-), similar to e.g. FT GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FT FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). FT Similar to Mycobacterium tuberculosis oxidoreductases e.g. FT Rv3107c" FT /db_xref="GOA:Q11061" FT /db_xref="InterPro:IPR016167" FT /db_xref="UniProtKB/TrEMBL:Q11061" FT /protein_id="CAB00895.1" FT /translation="MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAII FT RPRRTEEVQTVLRWASANQVPVVTRGAGSGLSGGATALDGGIVLSTEKMRDITVDPVTR FT TAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTGDYV FT LGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNASSIV FT VASFGSVQAAVDAVLGVTGRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDE FT RGRAATEDAAVMAAVFAENGAIDVFSTDDPDEGEAFIAARRFAIPAVESKGALLLEDVG FT VPLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEI FT MDLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI" FT CDS complement(23038..24297) FT /transl_table=11 FT /locus_tag="Rv1258c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT FT PROTEIN" FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF FT UNDETERMINATED SUBSTRATE (POSSIBLY MACROLIDE) ACROSS THE FT MEMBRANE (EXPORT). RESPONSIBLE FOR THE TRANSLOCATION OF THE FT UNDETERMINATED SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1258c, MTCY50.24, len: 419 aa. Probable conserved FT integral membrane transport (efflux) protein, possibly FT member of major facilitator superfamily (MFS), highly FT similar to O32859|TAP PROTEIN multidrug-resistance efflux FT pump from Mycobacterium fortuitum (409 aa), FASTA scores: FT E(): 0, (68.4% identity in 408 aa overlap). Contains FT PS00216 Sugar transport proteins signature 1." FT /db_xref="GOA:P64783" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/Swiss-Prot:P64783" FT /protein_id="CAB00894.1" FT /translation="MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQAS FT IVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVL FT VLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGL FT MIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNL FT RVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVL FT AIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRA FT AQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPA FT LRELDLAPQADIDRPVGSAQ" FT misc_feature complement(24064..24114) FT /note="PS00216 Sugar transport proteins signature 1" FT CDS 24296..25195 FT /transl_table=11 FT /locus_tag="Rv1259" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1259, (MTCY50.23c), len: 299 aa. Conserved FT hypothetical protein. Similar to AL109732|SC7H2.04 FT hypothetical protein from Streptomyces coelicolor (237 aa), FT FASTA scores: opt: 870, E(): 0, (57.1% identity in 231 aa FT overlap)." FT /db_xref="InterPro:IPR005122" FT /db_xref="UniProtKB/Swiss-Prot:P64785" FT /protein_id="CAB00912.1" FT /translation="MNIAAESSAKPVWGPPNFCAAAARMQDVRVLMHPKTGRAFRSPVE FT PGSGWPGDPATPQTPVAADAAQVSALAGGAGSICELNALISVCRACPRLVSWREEVAVV FT KRRAFADQPYWGRPVPGWGSKRPRLLILGLAPAAHGANRTGRMFTGDRSGDQLYAALHR FT AGLVNSPVSVDAADGLRANRIRITAPVRCAPPGNSPTPAERLTCSPWLNAEWRLVSDHI FT RAIVALGGFAWQVALRLAGASGTPKPRFGHGVVTELGAGVRLLGCYHPSQQNMFTGRLT FT PTMLDDIFREAKKLAGIE" FT CDS 25197..26315 FT /transl_table=11 FT /locus_tag="Rv1260" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv1260, (MTCY50.22c), len: 372 aa. Probable FT oxidoreductase (EC 1.-.-.-), highly similar to FT E1245747|AL021411 putative oxidoreductase SC7H1.18 from FT Streptomyces coelicolor (397 aa), FASTA scores: E(): FT 1.4e-29, (45.9% identity in 355 aa overlap); also some FT similarity to G912582 FAD binding protein homologue from FT Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245, FT E(): 2e-09, (27.5% identity in 251 aa overlap); FT PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 FT aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity FT in 360 aa overlap); TETX_BACFR|Q01911 tetracycline FT resistance protein (388 aa), FASTA scores: opt: 183, E(): FT 3e-05, (22.8% identity in 373 aa overlap). Also similar to FT Mycobacterium tuberculosis hypothetical proteins Rv0575c FT and Rv1751." FT /db_xref="GOA:Q11058" FT /db_xref="InterPro:IPR003042" FT /db_xref="UniProtKB/Swiss-Prot:Q11058" FT /protein_id="CAB00893.1" FT /translation="MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV FT RGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTESTPTGGPVNSPDIELLR FT DDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFERAAAREFDLVIGADGLHSNVR FT RLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTEARAALA FT FMDTELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSR FT GRVALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAGDDYQLGFANYHAEFHGFVER FT NQWLVSDNIPGGAPIPQEEFERIVHSITIKDY" FT CDS complement(26441..26890) FT /transl_table=11 FT /locus_tag="Rv1261c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1261c, (MTCY50.21), len: 149 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv1558|MTCY48.07c (39.2% FT identity in 125 aa overlap); Rv3547 and Rv3178." FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/Swiss-Prot:P64787" FT /protein_id="CAB00892.1" FT /translation="MDISRWLERHVGVQLLRLHDAIYRGTNGRIGHRIPGAPPSLLLHT FT TGAKTSQPRTTSLTYARDGDAYLIVASKGGDPRSPGWYHNLKANPDVEINVGPKRFGVT FT AKPVQPHDPDYARLWQIVNENNANRYTNYQSRTSRPIPVVVLTRR" FT CDS complement(26895..27329) FT /transl_table=11 FT /locus_tag="Rv1262c" FT /product="HYPOTHETICAL HIT-LIKE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1262c, (MTCY50.20), len: 144 aa. Hypothetical FT HIT-like protein, similar to Q04344|HIT_YEAST hit1 protein FT (orf u) (144 aa), FASTA scores: opt: 306, E(): 3e-14, (35.9 FT % identity in 142 aa overlap); also similar to FT YHIT_MYCGE|P47378 hypothetical 15.6 kDa protein (141 aa), FT FASTA scores: opt: 250, E(): 1.6e-10, (35.5% identity in FT 107 aa overlap); and YHIT_MYCLE|P49774 hypothetical 17.0 FT kDa protein hit-like (155 aa), FASTA scores: opt: 196, E(): FT 7e-07, (30.6% identity in 144 aa overlap). Similar to other FT proteins from Mycobacterium tuberculosis e.g. Rv2613c, FT Rv0759c. Contains PS00892 HIT family signature. BELONGS TO FT THE HIT FAMILY." FT /db_xref="GOA:Q11066" FT /db_xref="HSSP:1EMS" FT /db_xref="InterPro:IPR001310" FT /db_xref="UniProtKB/Swiss-Prot:Q11066" FT /protein_id="CAB00913.1" FT /translation="MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRH FT TVDLTDTPPEALADMVAIGQRIARAARATKLADATHIAINDGRAAFQTVFHVHLHVLPP FT RNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD" FT misc_feature complement(27030..27077) FT /note="PS00892 HIT family signature" FT CDS 27388..28776 FT /transl_table=11 FT /gene="amiB2" FT /locus_tag="Rv1263" FT /product="PROBABLE AMIDASE AMIB2 (AMINOHYDROLASE)" FT /function="INVOLVED IN CELLULAR METABOLISM, ACTIVE ON 2- to FT 6- CARBON ALIPHATIC AMIDES AND ON MANY AROMATIC AMIDES FT [CATALYTIC ACTIVITY : A MONOCARBOXYLIC ACID AMIDE + H(2)O = FT A MONOCARBOXYLATE + NH(3)]." FT /EC_number="3.5.1.4" FT /note="Rv1263, (MTCY50.19c), len: 462 aa. Probable amiB2, FT amidase (EC 3.5.1.4). Similar to G1001278 hypothetical 54.3 FT kDa protein (506 aa), FASTA scores: opt: 767, E(): 7.6e-40, FT (32.8% identity in 461 aa overlap), also similar to G580673 FT rhodococcus enantiose lective amidase gene (462 aa), FASTA FT scores, opt: 668, E(): 7.4e-34, (33.5% identity in 484 aa FT overlap) also to NYLA_PSES8|P13398 FT 6-aminohexanoate-cyclic-dimer hydrolase (492 aa), FASTA FT scores opt: 543, E(): 3.1e-26, (33.5% identity in 493 aa FT overlap). Also similar to MTCY274.19c (33.5% identity in FT 427 aa overlap). Similar to other putative amidases in M. FT tuberculosis; Rv2363, Rv2888c, etc. Contains PS00017 FT ATP/GTP-binding site motif A. BELONGS TO THE AMIDASE FT FAMILY." FT /db_xref="GOA:P63492" FT /db_xref="HSSP:1M21" FT /db_xref="InterPro:IPR000120" FT /db_xref="UniProtKB/Swiss-Prot:P63492" FT /protein_id="CAB00891.1" FT /translation="MDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERLDSHLRA FT YRVVQFDRARAEAEAAQQRLDAGERLPLLGVPIAIKDDVDIAGEVTTYGSAGHGPAATS FT DAEVVRRLRAAGAVIIGKTNVPELMIMPFTESLAFGATRNPWCLNRTPGGSSGGSAAAV FT AAGLAPVALGSDGGGSIRIPCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIARSVM FT DAALLLDATTTVPGPEGEFVAAAARQPGRLRIALSTRVPTPLPVRCGKQELAAVHQAGA FT LLRDLGHDVVVRDPDYPASTYANYLPRFFRGISDDADAQAHPDRLEARTRAIARLGSFF FT SDRRMAALRAAEVVLSSRIQSIFDDVDVVVTPGAATGPSRIGAYQRRGAVSTLLLVVQR FT VPYFQVWNLTGQPAAVVPWDFDGDGLPMSVQLVGRPYDEATLLALAAQIESARPWAHRR FT PSVS" FT misc_feature 27733..27756 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 28851..30044 FT /transl_table=11 FT /locus_tag="Rv1264" FT /product="ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) FT (ADENYLATE CYCLASE)" FT /function="POSSIBLY INVOLVED IN cAMP SYNTHESIS [CATALYTIC FT ACTIVITY: ATP = 3',5'-CYCLIC AMP + DIPHOSPHATE]." FT /EC_number="4.6.1.1" FT /note="Rv1264, (MTCY50.18c), len: 397 aa. Adenylate cyclase FT (EC 4.6.1.1) (function proven experimentally: see Linder et FT al., 2002), showing some similarity to other adenylate FT cyclases e.g. CYAA_BRELI|P27580 (403 aa), FASTA scores, FT opt: 270, E(): 1.3e-10, (29.3% identity in 317 aa overlap); FT etc. Similar to other putative cyclases in M. tuberculosis FT e.g. Rv2212, Rv1647. The C terminus seems to code for a FT catalytic domain belonging to a subfamily of adenylyl FT cyclase isozymes (mostly found in Gram-positive bacteria). FT The N terminus seems to be a potential novel regulator of FT adenylyl cyclase activity (autoinhibitory domain). BELONGS FT TO THE ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY." FT /db_xref="GOA:Q11055" FT /db_xref="InterPro:IPR001054" FT /db_xref="PDB:1Y10" FT /db_xref="UniProtKB/Swiss-Prot:Q11055" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00890.1" FT /translation="MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEI FT RATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHM FT RADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDI FT AKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFAD FT LVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTV FT LKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVR FT EALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP" FT CDS 30217..30897 FT /transl_table=11 FT /locus_tag="Rv1265" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN. SEEMS TO BE EXPRESSED DURING MACROPHAGE FT INFECTION." FT /note="Rv1265, (MTCY50.17c), len: 226 aa. Hypothetical FT unknown protein (see citation below)." FT /db_xref="UniProtKB/Swiss-Prot:P64789" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00889.1" FT /translation="MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHG FT RRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPE FT EESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMT FT RLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGP FT DLPA" FT CDS complement(30917..32797) FT /transl_table=11 FT /gene="pknH" FT /locus_tag="Rv1266c" FT /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN FT KINASE H PKNH (PROTEIN KINASE H) (STPK H)" FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO BE INVOLVED IN ARABINAN FT METABOLISM, PHOSPHORYLATING PERHAPS EMBR|Rv1267c [CATALYTIC FT ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]." FT /EC_number="2.7.1.-" FT /note="Rv1266c, (MTCY50.16), len: 626 aa. Probable pknH, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-) FT (see citation below), similar to many e.g. FT PKN1_MYXXA|P33973 pkn1 (693 aa), FASTA scores: opt: 611, FT E(): 1.4e- 14, (29.7% identity in 492 aa overlap); etc. FT Contains PS00107 Protein kinases ATP-binding region FT signature; PS00108 Serine/Threonine protein kinases FT active-site signature. Contains Hank's kinase subdomain. FT BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. FT Experimental studies show evidence of FT auto-phosphorylation." FT /db_xref="GOA:Q11053" FT /db_xref="HSSP:1O6Y" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:Q11053" FT /protein_id="CAB00914.1" FT /translation="MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVK FT LMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSV FT LKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGIASA FT TTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRADSAGT FT LVSSHLMGPIPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQ FT DHAADILRRSQESTLPAPPKPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPA FT QPGPAGQRPGPTGQPSWAPNSGPMPASGPTPTPQYYQGGGWGAPPSGGPSPWAQTPRKT FT NPWPLVAGAAAVVLVLVLGAIGIWIAIRPKPVQPPQPVAEERLSALLLNSSEVNAVMGS FT SSMQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHW FT VNQAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKAKTYRWTFADVKGSPPTITVI FT DTQEGAEGWECQRAMSVANNVVVDVNACGYRITNQAGQIAAKIVDKVNKE" FT misc_feature complement(32357..32395) FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT misc_feature complement(32663..32734) FT /note="PS00107 Protein kinases ATP-binding region FT signature" FT CDS complement(33138..34304) FT /transl_table=11 FT /gene="embR" FT /locus_tag="Rv1267c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM. THOUGHT FT TO REGULATE THE BIOSYNTHESIS OF THE MYCOBACTERIAL CELL WALL FT ARABINAN AND RESISTANCE TO ETHAMBUTOL (Emb; FT dextro-2,2'-(ethylenediimino)-di-1-butanol), REGULATING FT EMBA|Rv3794 AND EMBB|Rv3795." FT /note="Rv1267c, (MT1305, MTCY50.15), len: 388 aa. Probable FT embR, regulatory protein (see citation below), similar to FT many e.g. AFSR_STRCO|P25941 regulatory protein AfsR from FT Streptomyces coelicolor (993 aa), FASTA scores: opt: 489, FT E(): 1e-25, (33.5% identity in 361 aa overlap); etc. FT BELONGS TO THE AFSR/DNRI/REDD FAMILY OF REGULATORS." FT /db_xref="GOA:P66799" FT /db_xref="InterPro:IPR011991" FT /db_xref="PDB:2FEZ" FT /db_xref="UniProtKB/Swiss-Prot:P66799" FT /protein_id="CAB00888.1" FT /translation="MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVIN FT RNRPVGVDALITALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLS FT IPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFA FT TALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQS FT DALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRT FT MASGQQAVAYLHDIASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYV FT INDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT" FT CDS complement(34615..35313) FT /transl_table=11 FT /locus_tag="Rv1268c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1268c, (MTCY50.14), len: 232 aa. Hypothetical FT unknown protein, probably secreted protein : contains FT possible signal peptide sequence (score 7.9 at residue FT 28)." FT /db_xref="UniProtKB/Swiss-Prot:P64791" FT /protein_id="CAB00911.1" FT /translation="MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAAA FT KYWRQQTYDDCVLMSAADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAEHP FT NSGMGTSVADIPTLLAHYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSINAE FT MIWGQPVEETDSAGNPRSDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFVEAWA FT TSHDFMAVTT" FT CDS complement(35536..35910) FT /transl_table=11 FT /locus_tag="Rv1269c" FT /product="CONSERVED PROBABLE SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv1269c, (MTCY50.13), len: 124 aa. Conserved FT probable exported protein with putative N-terminal signal FT sequence. Similar to Mycobacterium tuberculosis protein FT Rv1813c|Y0DU_MYCTU|Q50620 hypothetical protein cy1a11.30 FT (137 aa), FASTA scores: E(): 9e-21, (41.6% identity in 137 FT aa overlap)." FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/Swiss-Prot:P0A5E1" FT /protein_id="CAB00910.1" FT /translation="MTTMITLRRRFAVAVAGVATAAATTVTLAPAPANAADVYGAIAYS FT GNGSWGRSWDYPTRAAAEATAVKSCGYSDCKVLTSFTACGAVAANDRAYQGGVGPTLAA FT AMKDALTKLGGGYIDTWACN" FT CDS complement(35971..36705) FT /transl_table=11 FT /gene="lprA" FT /locus_tag="Rv1270c" FT /product="POSSIBLE LIPOPROTEIN LPRA" FT /function="UNKNOWN" FT /note="Rv1270c, (MTCY50.12), len: 244 aa. Possible lprA, FT lipoprotein. Similar to O32852|AJ000500 lipoprotein from FT Mycobacterium bovis (236 aa), fasta scores: E(): 5.2e-23, FT (35.1% identity in 245 aa overlap). Similar to M. FT tuberculosis lipoproteins: Rv1368, Rv1411c, Rv2945c. FT Contains probable N-terminal signal sequence." FT /db_xref="GOA:Q11049" FT /db_xref="InterPro:IPR009830" FT /db_xref="UniProtKB/Swiss-Prot:Q11049" FT /protein_id="CAB00915.1" FT /translation="MKHPPCSVVAAATAILAVVLAIGGCSTEGDAGKASDTAATASNGD FT AAMLLKQATDAMRKVTGMHVRLAVTGDVPNLRVTKLEGDISNTPQTVATGSATLLVGNK FT SEDAKFVYVDGHLYSDLGQPGTYTDFGNGASIYNVSVLLDPNKGLANLLANLKDASVAG FT SQQADGVATTKITGNSSADDIATLAGSRLTSEDVKTVPTTVWIASDGSSHLVQIQIAPT FT KDTSVTLTMSDWGKQVTATKPV" FT CDS complement(36918..37259) FT /transl_table=11 FT /locus_tag="Rv1271c" FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv1271c, (MTCY50.11), len: 113 aa. Conserved FT hypothetical exported protein with potential N-terminal FT signal sequence. Similar to Mycobacterium tuberculosis FT hypothetical proteins Rv1804c, Rv1810, Rv0622, etc." FT /db_xref="InterPro:IPR007969" FT /db_xref="UniProtKB/Swiss-Prot:P64793" FT /protein_id="CAB00909.1" FT /translation="MLSPLSPRIIAAFTTAVGAAAIGLAVATAGTAGANTKDEAFIAQM FT ESIGVTFSSPQVATQQAQLVCKKLASGETGTEIAEEVLSQTNLTTKQAAYFVVDATKAY FT CPQYASQLT" FT CDS complement(37367..39262) FT /transl_table=11 FT /locus_tag="Rv1272c" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1272c, (MTCY50.10), len: 631 aa. Probable FT drugs-transport transmembrane ATP-binding protein ABC FT transporter (see citation below), similar to e.g. FT Y015_MYCGE|P47261 hypothetical ABC transporter mg015m from FT Mycoplasma genitalium (589 aa), FASTA scores: opt: 1054, FT E(): 0, (34.3% identity in 522 aa overlap); etc. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop); and PS00211 FT ABC transporters family signature. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), FT MSBA SUBFAMILY." FT /db_xref="GOA:P63397" FT /db_xref="HSSP:1MT0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P63397" FT /protein_id="CAB00908.1" FT /translation="MTAPPGARPRAASPPPNMRSRDFWGSAARLVKRLAPQRRLSIAVI FT TLGIAGTTIGVIVPRILGHATDLLFNGVIGRGLPGGITKAQAVASARARGDNTFADLLS FT GMNVVPGQGVDFAAVERTLALALALYLAAALMIWAQARLLNLTVQKTMVRLRTDVEDKV FT HRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTISQLVTSILTMVAVLAMMVSISGLL FT ALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLNAHLEETYSGFTVVKTFGHQAAA FT RERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYVAVAVAGGLQVATGQITLGSIQ FT AFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDEPEESPEPEPELPNLTGRVEF FT EHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTGAGKTTLVNLLMRFYEIGSGRILIDG FT VDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGRPEATTDEIVEAARAAHVDRFVN FT TLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLLILDEATSSVDTRTELLIQRAM FT RELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNHAELLARRGVYYQMTRA" FT misc_feature complement(37619..37663) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(37952..37975) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(39259..41007) FT /transl_table=11 FT /locus_tag="Rv1273c" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1273c, (MTCY50.09), len: 582 aa. Probable FT drugs-transport transmembrane ATP-binding protein ABC FT transporter (see citation below), similar to e.g. FT YWJA_BACSU|P45861 hypothetical abc transporter from B. FT subtilis (575 aa), FASTA scores: opt: 810, E(): 0, (27.0% FT identity in 578 aa overlap); etc. Contains PS00136 Serine FT proteases, subtilase family, aspartic acid active site; 2 x FT PS00211 ABC transporters family signature; and PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), FT MSBA SUBFAMILY." FT /db_xref="GOA:P0A4W4" FT /db_xref="HSSP:1JJ7" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P0A4W4" FT /protein_id="CAB00907.1" FT /translation="MLLALLRQHIRPYRRLVAMLMMLQLVSTLASLYLPTVNAAIVDDG FT VAKGDTATIVRLGAVMLGVTGLQVLCAIGAVYLGSRTGAGFGRDLRSAMFEHIITFSER FT ETARFGAPTLLTRSTNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWLLLV FT SVPILAVANYWIISHMLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERDKFAQ FT ANTALSNAALSAGNWQALMLPVTTLTINASSVALIWFGGLRIDSGQMQVGSLIAFLSYF FT AQILMAVLMATMTLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGVVRLAGA FT TFTYPGADCPVLQDISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGAVLVDGID FT VREYHTERLWSAIGLVPQRSYLFSGTVADNLRYGGGPDQVVTEQEMWEALRVAAADGFV FT QTDGLQTRVAQGGVNFSGGQRQRLAIARAVIRRPAIYVFDDAFSALDVHTDAKVHASLR FT QVSGDATIIVVTQRISNAAQADQVIVVDNGKIVGTGTHETLLADCPTYAEFAASQSLSA FT TVGGVG" FT misc_feature complement(39544..39588) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(39880..39903) FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature complement(40270..40314) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(40858..40893) FT /note="PS00136 Serine proteases, subtilase family, aspartic FT acid active site" FT CDS 41154..41711 FT /transl_table=11 FT /gene="lprB" FT /locus_tag="Rv1274" FT /product="POSSIBLE LIPOPROTEIN LPRB" FT /function="UNKNOWN" FT /note="Rv1274, (MTCY50.08c), len: 185 aa. Possible lprB, FT lipoprotein; contains possible N-terminal signal sequence FT and appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013) . Some similarity to Rv1275." FT /db_xref="GOA:Q11045" FT /db_xref="UniProtKB/Swiss-Prot:Q11045" FT /protein_id="CAB00906.1" FT /translation="MRRKVRRLTLAVSALVALFPAVAGCSDSGDNKPGATIPSTPANAE FT GRHGPFFPQCGGVSDQTVTELTRVTGLVNTAKNSVGCQWLAGGGILGPHFSFSWYRGSP FT IGRERKTEELSRASVEDINIDGHSGFIAIGNEPSLGDSLCEVGIQFSDDFIEWSVSFSQ FT KPFPLPCDIAKELTRQSIANSK" FT CDS 41708..42250 FT /transl_table=11 FT /gene="lprC" FT /locus_tag="Rv1275" FT /product="POSSIBLE LIPOPROTEIN LPRC" FT /function="UNKNOWN" FT /note="Rv1275, (MTCY50.07c), len: 180 aa. Possible lprC, FT lipoprotein; contains possible N-terminal signal sequence FT and appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013). Some similarity to Rv1274." FT /db_xref="UniProtKB/TrEMBL:O86337" FT /protein_id="CAB00916.1" FT /translation="MRRVLVGAAALITALLVLTGCTKSISGTAVKAGGAGVPRNNNSQE FT RYPNLLKECEVLTTDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGS FT LSNERKVAEGLKYQVETRAIQGVDSIVMRTGDPNGACGVASDAAGVVGWWVNPQAPGID FT ACGQAIKLMELTLATNA" FT CDS complement(42395..42871) FT /transl_table=11 FT /locus_tag="Rv1276c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1276c, (MTCY50.06), len: 158 aa. Conserved FT hypothetical protein, similar to AL096844|SCI28.03 FT hypothetical protein from Streptomyces coelicolor (172 aa), FT FASTA scores: opt: 385, E(): 3.3e-19, (43.5% identity in FT 161 aa overlap). Some similarity to P76502|SIXA_ECOLI FT PHOSPHOHISTIDINE PHOSPHATASE SIXA (161 aa), FASTA scores: FT opt: 146, E(): 0.0047, (31.9% identity in 116 aa overlap). FT BELONGS TO THE SIXA FAMILY OF PHOSPHATASES." FT /db_xref="GOA:Q11043" FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/Swiss-Prot:Q11043" FT /protein_id="CAB00905.1" FT /translation="MRHAKSAYPDGIADHDRPLAPRGIREAGLAGGWLRANLPAVDAVL FT CSTATRARQTLAHTGIDAPARYAERLYGAAPGTVIEEINRVGDNVTTLLVVGHEPTTSA FT LAIVLASISGTDAAVAERISEKFPTSGIAVLRVAGHWADVEPGCAALVGFHVPR" FT CDS 43121..44374 FT /transl_table=11 FT /locus_tag="Rv1277" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1277, (MTCY50.05c), len: 417 aa. Conserved FT hypothetical protein, some similarity to FT 3914967|O68033|SBCD_RHOCA EXONUCLEASE SBCD HOMOLOG from FT Rhodobacter capsulatus (405 aa). May be sbcD protein (see FT Mizrahi & Andersen 1998)" FT /db_xref="GOA:Q50699" FT /db_xref="InterPro:IPR014577" FT /db_xref="UniProtKB/TrEMBL:Q50699" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00917.1" FT /translation="MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQL FT GMTRHFLAGDAQPRYSAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQSL FT EAMRVIGLPVYLLPGNHDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQIVAA FT PWRSKAPTTDPVAEVLAGLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDALTRQ FT AIHYVALGDKHSLTQVGSSGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPRHPVTV FT DARRIGRWRFVTLHHQVDTSRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTDRAALDT FT CLDKYARLFAWLGLWERHTDLAVIPVDAEFTDLGIGGFAAAAVDELVATARGGDDESAV FT DAQAALALLLRLADRGAA" FT CDS 44371..46998 FT /transl_table=11 FT /locus_tag="Rv1278" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1278, (MTCY50.04c), len: 875. Hypothetical unknown FT protein, possible coiled-coil regions, contains PS00017 FT ATP/GTP-binding site motif A." FT /db_xref="UniProtKB/Swiss-Prot:P64795" FT /protein_id="CAB00904.1" FT /translation="MKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEALD FT LLLEYKDRSTKKEVKQVKPTNADVGSEVIAEISSGPYRFVYRKRFHKRCETELTVLAPR FT REQLTGDEAHERVRTMLAETVDTELWHAQRVLQAASTAAVDLSGCDALSRALDLAAGDD FT AALSGTESLLIERIEAEYARYFTPTGRPTGEWSAAVSRLAAAEAAVADCAAAVAEVDDG FT VRRHTELTEQVAELSQQLLAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAATSGAS FT TAAHAGRLGLLTEIDTRTAAVVAAEAKARQAADEQATARAEAEACDAALTEATQVLTAV FT RLRAESARRTLDQLADCEEADRLAARLARIDDIEGDRDRVCAELSAVTLTEELLSRIER FT AAAAVDRGGAQLASISAAVEFTAAVDIELGVGDQRVSLSAGQSWSVTATGPTEVKVPGV FT LTARIVPGATALDFQAKYAAAQQELADALAAGEVADLAAARSADLCRRELLSRRDQLTA FT TLAGLCGDEQVDQLRSRLEQLCAGQPAELDLVSTDTATARAELDAVEAARIAAEKDCET FT RRQIAAGAARRLAETSTRATVLQNAAAAESAELGAAMTRLACERASVGDDELAAKAEAD FT LRVLQTAEQRVIDLADELAATAPDAVAAELAEAADAVELLRERHDEAIRALHEVGVELS FT VFGTQGRKGKLDAAETEREHAASHHARVGRRARAARLLRSVMARHRDTTRLRYVEPYRA FT ELHRLGRPVFGPSFEVEVDTDLRIRSRTLDDRTVPYECLSGGAKEQLGILARLAGAALV FT AKEDAVPVLIDDALGFTDPERLAKMGEVFDTIGADGQVIVLTCSPTRYGGVKGAHRIDL FT DAIQ" FT misc_feature 44461..44484 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 47019..48605 FT /transl_table=11 FT /locus_tag="Rv1279" FT /product="PROBABLE DEHYDROGENASE FAD flavoprotein GMC FT oxidoreductase" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM, PROBABLY ELECTRON-TRANSFER-LINKED." FT /EC_number="1.1.-.-" FT /note="Rv1279, (MTCY50.03c), len: 528 aa. Probable FT dehydrogenase, FAD flavoprotein GMC oxidoreductase (EC FT 1.1.-.-), similar to several e.g. dBETA_ECOLI|P17444 FT choline dehydrogenase from Escherichia coli (556 aa), FASTA FT scores, opt: 1047, E(): 0, (37.7% identity in 541 aa FT overlap). Similar to Rv0697 putative Mycobacterium FT tuberculosis GMC oxidoreductase. Contains PS00623 GMC FT oxidoreductases signature 1, and PS00624 GMC FT oxidoreductases signature 2. BELONGS TO THE GMC FT OXIDOREDUCTASES FAMILY." FT /db_xref="GOA:P64263" FT /db_xref="InterPro:IPR007867" FT /db_xref="UniProtKB/Swiss-Prot:P64263" FT /protein_id="CAB00903.1" FT /translation="MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFI FT GVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVRGFASDYD FT EWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWL FT AAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATAT FT RVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDID FT TVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNVGEAYGF FT VRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAK FT PVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELA FT LATCSHTLYHPMGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVL FT IGEKAADLIRS" FT misc_feature 47259..47330 FT /note="PS00623 GMC oxidoreductases signature 1" FT misc_feature 47784..47828 FT /note="PS00624 GMC oxidoreductases signature 2" FT CDS complement(48622..50397) FT /transl_table=11 FT /gene="oppA" FT /locus_tag="Rv1280c" FT /product="PROBABLE PERIPLASMIC OLIGOPEPTIDE-BINDING FT LIPOPROTEIN OPPA" FT /function="INVOLVED IN ACTIVE TRANSPORT OF OLIGOPEPTIDE FT ACROSS THE MEMBRANE (IMPORT). THIS PROTEIN IS A COMPONENT FT OF THE OLIGOPEPTIDE PERMEASE, A BINDING PROTEIN-DEPENDENT FT TRANSPORT SYSTEM; IT BINDS PEPTIDES UP TO FIVE AMINO ACIDS FT LONG WITH HIGH AFFINITY." FT /note="Rv1280c, (MTCY50.02), len: 591 aa. Probable oppA, FT oligopeptide-binding lipoprotein component of peptide FT transport system (see citation below), sharing some FT similarity to other periplasmic solute binding proteins FT e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding FT protein from Salmonella typhimurium (542 aa), FASTA scores: FT E(): 5.1e-05, (22.1% identity in 458 aa overlap); etc. Also FT similar to Rv1166 and Rv2585c from Mycobacterium FT tuberculosis. Has possible N-terminal signal sequence and FT prokaryotic lipoprotein lipid attachment site (PS00013). FT BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING FT PROTEIN FAMILY 5." FT /db_xref="GOA:P66771" FT /db_xref="InterPro:IPR000914" FT /db_xref="UniProtKB/Swiss-Prot:P66771" FT /protein_id="CAB00902.1" FT /translation="MADRGQRRGCAPGIASALRASFQGKSRPWTQTRYWAFALLTPLVV FT AMVLTGCSASGTQLELAPTADRRAAVGTTSDINQQDPATLQDGGNLRLSLTDFPPNFNI FT LHIDGNNAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTRTAPQVVTYTINPEAV FT WSDGTPITWRDIASQIHAISGADKAFEIASSSGAERVASVTRGVDDRQAVVTFAKPYAE FT WRGMFAGNGMLLPASMTATPEAFNKGQLDGPGPSAGPFVVSALDRTAQRIVLTRNPRWW FT GARPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAARTKGISIRRAPGPSWY FT HFTLNGAPGSILADKALRLAIAKGIDRYTIARVAQYGLTSDPVPLNNHVFVAGQDGYQD FT NSGVVAYNPEQAKRELDALGWRRSGAFREKDGRQLVIRDLFYDAQSTRQFAQIAQHTLA FT QIGVKLELQAKSGSGFFSDYVNVGAFDIAQFGWVGDAFPLSSLTQIYASDGESNFGKIG FT SPQIDAAIERTLAELDPGKARALANQVDELIWAEGFSLPLTQSPGTVAVRSTLANFGAT FT GLADLDYTAIGFMRR" FT CDS complement(50390..52228) FT /transl_table=11 FT /gene="oppD" FT /locus_tag="Rv1281c" FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT ATP-BINDING FT PROTEIN ABC TRANSPORTER OPPD" FT /function="INVOLVED IN ACTIVE TRANSPORT OF OLIGOPEPTIDE FT ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR ENERGY FT COUPLING TO THE TRANSPORT SYSTEM." FT /note="Rv1281c, (MTCY50.01), len: 612 aa. Probable oppD, FT oligopeptide-transport ATP-binding protein ABC transporter FT (see citation below), similar to others e.g. FT DPPD_BACSU|P26905 dipeptide transport ATP-binding protein FT from Bacillus subtilis (335 aa), FASTA scores: opt: 983, FT E(): 0, (48.6% identity in 319 aa overlap); etc. Contains 2 FT x PS00017 ATP/GTP-binding site motif A (P-loop); 2 x FT PS00211 ABC transporters family signature.BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:P63395" FT /db_xref="HSSP:1B0U" FT /db_xref="InterPro:IPR013563" FT /db_xref="UniProtKB/Swiss-Prot:P63395" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00901.1" FT /translation="MSPLLEVTDLAVTFRTDGDPVTAVRGISYRVEPGEVVAMVGESGS FT GKSAAAMAVVGLLPEYAQVRGSVRLQGTELLGLADNAMSRFRGKAIGTVFQDPMSALTP FT VYTVGDQIAEAIEVHQPRVGKKAARRRAVELLDLVGISQPQRRSRAFPHELSGGERQRV FT VIAIAIANDPDLLICDEPTTALDVTVQAQILDVLKAARDVTGAGVLIITHDLGVVAEFA FT DRALVMYAGRVVESAGVNDLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAG FT LAPGCPFAPRCPLVIDECLTAEPELLDVATDHRAACIRTELVTGRSAADIYRVKTEARP FT AALGDASVVVRVRHLVKTYRLAKGVVLRRAIGEVRAVDGISLELRQGRTLGIVGESGSG FT KSTTLHEILELAAPQSGSIEVLGTDVATLGTAERRSLRRDIQVVFQDPVASLDPRLPVF FT DLIAEPLQANGFGKNETHARVAELLDIVGLRHGDASRYPAEFSGGQKQRIGIARALALQ FT PKILALDEPVSALDVSIQAGIINLLLDLQEQFGLSYLFVSHDLSVVKHLAHQVAVMLAG FT TVVEQGDSEEVFGNPKHEYTRRLLGAVPQPDPARRG" FT misc_feature complement(50687..50731) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(51026..51049) FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature complement(51722..51766) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(52085..52108) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(52225..53100) FT /transl_table=11 FT /gene="oppC" FT /locus_tag="Rv1282c" FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER OPPC" FT /function="INVOLVED IN ACTIVE TRANSPORT OF OLIGOPEPTIDE FT ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1282c, (MTCY373.01c-MTCY3H3.01), len: 291 aa. FT Probable oppC, oligopeptide-transport integral membrane FT protein ABC transporter (see citation below), similar to FT other integral membrane proteins e.g. OPPC_ECOLI|P77664 FT oligopeptide transport system permease from Escherichia FT coli (302 aa), FASTA scores: E(): 4.6e-33, (40.7% identity FT in 275 aa overlap); etc. Also similar to Rv3664c|DPPC FT probable peptide-transport integral membrane protein from FT Mycobacterium tuberculosis." FT /db_xref="GOA:P66964" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/Swiss-Prot:P66964" FT /protein_id="CAB01002.1" FT /translation="MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPYS FT YDDLDFNALLQPPGTKHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATVGA FT ISGYFGGWRDRTLMWVVDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMISSR FT MVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILAETGL FT SFLGFGIQPPDVSLGTLIADGTASATAFPWVFLFPASILVLILVCANLTGDGLRDALDP FT ASRSLRRGVR" FT CDS complement(53097..54074) FT /transl_table=11 FT /gene="oppB" FT /locus_tag="Rv1283c" FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER OPPB" FT /function="INVOLVED IN ACTIVE TRANSPORT OF OLIGOPEPTIDE FT ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1283c, (MTCY373.02c), len: 325 aa. Probable oppB, FT oligopeptide-transport integral membrane protein ABC FT transporter (see citation below), similar to other integral FT membrane proteins e.g. DPPB_ECOLI|P37316 dipeptide FT transport system permease protein from Escherichia coli FT (339 aa), FASTA scores: opt: 402, E(): 3.4e-20, (31.0% FT identity in 345 aa overlap); etc. Also similar to FT Rv3665c|DppB probable peptide-transport integral membrane FT protein from Mycobacterium tuberculosis. Contains PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp signature." FT /db_xref="GOA:P66966" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/Swiss-Prot:P66966" FT /protein_id="CAA97749.1" FT /translation="MTRYLARRLLNYLVLLALASFLTYCLTSLAFSPLESLMQRSPRPP FT QAVIDAKAHDLGLDRPILARYANWVSHAVRGDFGTTITGQPVGTELGRRIGVSLRLLVV FT GSVFGTVAGVVIGAWGAIRQYRLSDRVMTTLALLVLSTPTFVVANLLILGALRVNWAVG FT IQLFDYTGETSPGVAGGVWDRLGDRLQHLILPSLTLALAAAAGFSRYQRNAMLDVLGQD FT FIRTARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGAVFVEKIFGWHGMGEWM FT VRGISTQDTNIVAAITVFSGAVVLLAGLLSDVIYAALDPRVRVS" FT misc_feature complement(53343..53429) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp signature." FT CDS 54281..54772 FT /transl_table=11 FT /locus_tag="Rv1284" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1284, (MTCY373.03), len: 163 aa. Conserved FT hypothetical protein, similar to AL109663|SC4A10.26 FT hypothetical protein from Streptomyces coelicolor (167 aa), FT FASTA scores: opt: 567, E(): 1.5e-32, (53.4% identity in FT 163 aa overla); shows some similarity to hypothetical FT protein from Methanobacterium thermoautotrophicum. Weak FT similarity to carbonic anhydrases e.g. FT U51624|MTU516242|P17582 Methanothermobacter FT thermautotrophicus (171 aa), FASTA score: opt: 305, E(): 1 FT .2e-14, (35.2% identity in 165 aa overlap)." FT /db_xref="GOA:P64797" FT /db_xref="InterPro:IPR001765" FT /db_xref="PDB:1YLK" FT /db_xref="UniProtKB/Swiss-Prot:P64797" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97750.1" FT /translation="MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRM FT LGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRA FT IQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP FT " FT CDS 54866..55864 FT /transl_table=11 FT /gene="cysD" FT /locus_tag="Rv1285" FT /product="PROBABLE SULFATE ADENYLYLTRANSFERASE SUBUNIT 2 FT CYSD" FT /function="INVOLVED IN SULFATE ACTIVATION PATHWAY. FIRST FT STEP IN THE SULFATE ACTIVATION PATHWAY. THIS REACTION FT OCCURS EARLY IN THE REDUCTIVE BRANCH OF THE CYSTEINE FT BIOSYNTHETIC PATHWAY [CATALYTIC ACTIVITY :ATP + SULFATE = FT DIPHOSPHATE + ADENYLYLSULFATE]" FT /EC_number="2.7.7.4" FT /note="Rv1285, (MTCY373.04), len: 332 aa. Probable cysD, FT sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (see FT Wooff et al., 2002), homology suggests start site at aa 24 FT or 28, similar to e.g. CYSD_ECOLI|P21156 sulfate adenylate FT transferase subunit 2 from Escherichia coli (302 aa), FASTA FT score: opt: 973, E():0, (52.5% identity in 303 aa overlap). FT Also similar to Mycobacterium tuberculosis Rv2392, FT 3'-phosphoadenylylsulfate reductase. BELONGS TO THE PAPS FT REDUCTASE FAMILY. CYSD SUBFAMILY. Thought to be FT differentially expressed within host cells (see Triccas et FT al., 1999)." FT /db_xref="GOA:P65670" FT /db_xref="InterPro:IPR011784" FT /db_xref="UniProtKB/Swiss-Prot:P65670" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97751.1" FT /translation="MAITINMVNPTGFIRYEDVEQEAMTSDVTVGPAPGQYQLSHLRLL FT EAEAIHVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNFDE FT VIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDAAFG FT GARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEF FT DIWSYIGAEQVRLPSIYFAHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFRTVGDV FT TCTGCVESSASTVAEVIAETAVARLTERGATRADDRISEAGMEDRKRQGYF" FT CDS 55864..57708 FT /transl_table=11 FT /gene="cysN" FT /locus_tag="Rv1286" FT /product="PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC: SULFATE FT ADENYLTRANSFERASE (SUBUNIT 1) + ADENYLYLSULFATE KINASE" FT /function="ATP SULFURYLASE MAY BE THE GTPASE, REGULATING FT ATP SULFURYLASE ACTIVITY [CATALYTIC ACTIVITY 1: ATP + FT SULFATE = DIPHOSPHATE + ADENYLYLSULFATE] AND APS KINASE FT CATALYZES THE SYNTHESIS OF ACTIVATED SULFATE [CATALYTIC FT ACTIVITY 2: ATP + ADENYLYLSULFATE = ADP + 3'- FT PHOSPHOADENYLYLSULFATE]. FIRST AND SECOND STEPS IN THE FT SULFATE ACTIVATION PATHWAY. THESE REACTIONS OCCURS EARLY IN FT THE REDUCTIVE BRANCH OF THE CYSTEINE BIOSYNTHETIC PATHWAY." FT /EC_number="2.7.7.4" FT /EC_number="2.7.1.25" FT /note="Rv1286, (MTCY373.05), len: 614 aa. Probable FT cysN/cysC bifunctional enzyme, sulfate adenylyltransferase FT subunit 1 (EC 2.7.7.4) and Adenylylsulfate kinase (EC FT 2.7.1.25) (see Wooff et al., 2002), similar to FT CYSN_ECOLI|P23845 sulfate adenylate transferase subunit 1 FT from Escherichia coli (475 aa), FASTA scores: opt: 1291, FT E():0, (50.2% identity in 428 aa overlap). Contains 2 x FT PS00017 ATP/GTP-binding site motif A, PS00301 GTP-binding FT elongation factors signature." FT /db_xref="GOA:Q10600" FT /db_xref="HSSP:1M7G" FT /db_xref="InterPro:IPR004161" FT /db_xref="UniProtKB/Swiss-Prot:Q10600" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97752.1" FT /translation="MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVEQTSKD FT RGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGAS FT TAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVLAVNKMDLLGWDQEKFDAIRDEFH FT AFAARLDVQDVTSIPISALHGDNVVTKSDQTPWYEGPSLLSHLEDVYIAGDRNMVDVRF FT PVQYVIRPHTLEHQDHRSYAGTVASGVMRSGDEVVVLPIGKTTRITAIDGPNGPVAEAF FT PPMAVSVRLADDIDISRGDMIARTHNQPRITQEFDATVCWMADNAVLEPGRDYVVKHTT FT RTVRARIAGLDYRLDVNTLHRDKTATALKLNELGRVSLRTQVPLLLDEYTRNASTGSFI FT LIDPDTNGTVAAGMVLRDVSARTPSPNTVRHRSLVTAQDRPPRGKTVWFTGLSGSGKSS FT VAMLVERKLLEKGISAYVLDGDNLRHGLNADLGFSMADRAENLRRLSHVATLLADCGHL FT VLVPAISPLAEHRALARKVHADAGIDFFEVFCDTPLQDCERRDPKGLYAKARAGEITHF FT TGIDSPYQRPKNPDLRLTPDRSIDEQAQEVIDLLESSS" FT misc_feature 55894..55917 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 56035..56082 FT /note="PS00301 GTP-binding elongation factors signature" FT misc_feature 57211..57234 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 57762..58247 FT /transl_table=11 FT /locus_tag="Rv1287" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1287, (MTCY373.06), len: 161 aa. Conserved FT hypothetical protein, similar to VJEB family of proteins FT e.g. FASTA score: P44675|Y379_HAEIN HYPOTHETICAL PROTEIN FT HI0379 (150 aa), FASTA scores: opt: 213, E(): 2.5e-08, FT (30.0% identity in 130 aa overlap) and YJEB_ECOLI|P21498 FT hypothetical 15.6 kDa protein in pura-vacb (141 aa), opt: FT 167, E(): 9.5e-06, (25.0% identity in 136 aa overlap). FT BELONGS TO THE UPF0074 (RFF2) FAMILY." FT /db_xref="GOA:P67159" FT /db_xref="InterPro:IPR000944" FT /db_xref="UniProtKB/Swiss-Prot:P67159" FT /protein_id="CAA97753.1" FT /translation="MRMSAKAEYAVRAMVQLATAASGTVVKTDDLAAAQGIPPQFLVDI FT LTNLRTDRLVRSHRGREGGYELARPGTEISIADVLRCIDGPLASVRDIGLGDLPYSGPT FT TALTDVWRALRASMRSVLEETTLADVAGGALPEHVAQLADDYRAQESTRHGASRHGD" FT CDS 58305..59675 FT /transl_table=11 FT /locus_tag="Rv1288" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1288, (MTCY373.07), len: 456 aa. Conserved FT hypothetical protein, some similarity to A85B_MYCTU|P31952 FT antigen 85-b precursor (85b) (325 aa), FASTA scores: opt: FT 199, E(): 2.7e-06, (24.7% identity in 279 aa overlap). Also FT similar to Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (related FT to antigen 85 complex) from Corynebacterium glutamicum (657 FT aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity FT in 352 aa overlap). SEEMS TO CONTAIN 3 LYSM REPEATS" FT /db_xref="GOA:Q10614" FT /db_xref="InterPro:IPR002482" FT /db_xref="UniProtKB/Swiss-Prot:Q10614" FT /protein_id="CAA97754.1" FT /translation="MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVG FT QRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDF FT TRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLR FT IVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRT FT FDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRT FT YAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAV FT LDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVL FT AGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD" FT CDS 59724..60356 FT /transl_table=11 FT /locus_tag="Rv1289" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1289, (MTCY373.08), len: 210 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64799" FT /protein_id="CAA97755.1" FT /translation="MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLGV FT GTRFRTALRDSLDIYGVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWLHG FT HADESSVEFEVSPYVNASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPPDYQ FT LSWYDHVFFISVWWGWQDHFREIVNVDRASLVALDFGDLWNGWTPVG" FT CDS complement(60439..62004) FT /transl_table=11 FT /locus_tag="Rv1290c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN VIRULENCE." FT /note="Rv1290c, (MTCY373.09c), len: 521 aa. Conserved FT hypothetical protein (see citation below), similar to FT AL031013|SC8A6.09 hypothetical protein from Streptomyces FT coelicolor (443 aa), FASTA scores: opt: 371, E(): 9.5e-17, FT (28.3% identity in 446 aa overlap)." FT /db_xref="GOA:P0A5E3" FT /db_xref="InterPro:IPR018723" FT /db_xref="UniProtKB/Swiss-Prot:P0A5E3" FT /protein_id="CAA97756.1" FT /translation="MLQRSLGVNGRKLAMSARSAKRERKNASTAASKCYVVPPSARGWV FT HAYSVTATSMLNRRKAILDYLQGAVWVLPTFGVAIGLGSGAVLSMIPVKSGTLIDKLMF FT QGTPGDARGVLIVVSATMITTIGIVFSLTVLSLQIASSQFSVRLLRTFLRDVPNQVVLA FT IFACTFAYSTGGLHTVGEHRDGGAFIPKVAVTGSLALAFVSIAALIYFLHHLMHSIQID FT TIMDKVRLRTLGLVDQLYPESDTADRQVETPPSPPADAVPLLAPHSGYLQTVDVDDIAE FT LAAASRYTALLVTFVGDYVTAGGLLGWCWRRGTAPGAPGSDFPQRCLRHVHIGFERTLQ FT QDIRFGLRQMVDIALRALSPALNDPYTAIQVVHHLSAVESVLASRALPDDVRRDRAGEL FT LFWLPYPSFATYLHVGCAQIRRYGSREPLVLTALLQLLSAVAQNCVDPSRRVAVQTQIA FT LVVRAAQREFADESDRAMVLGAAARATEVVERPGTLAPPPSTFGQVAAAQAAASTIRSA FT DRDG" FT CDS 62015..62329 FT /transl_table=11 FT /locus_tag="Rv1290A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1290A, len: 104 aa. Hypothetical unknown protein, FT equivalent to AAK45590 from Mycobacterium tuberculosis FT strain CDC1551 (122 aa) but shorter 18 aa." FT /db_xref="UniProtKB/TrEMBL:Q79FQ6" FT /protein_id="CAE55375.1" FT /translation="MLALHGLSEGVSGSGGSGGRWGAGEVLEGARIGVIADGVSCFPTK FT ADCRRIRGVPVFDGYTRMVARLMGSLAVLRSVSIPKGYRDFGFGSLRAVAPKNCPDVSG FT " FT CDS complement(62456..62791) FT /transl_table=11 FT /locus_tag="Rv1291c" FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv1291c, (MTCY373.10c), len: 111 aa. Conserved FT hypothetical secreted protein, similar to others in FT Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU FT HYPOTHETICAL 11.6 kDa PROTEIN (113 aa), FASTA score: opt: FT 246, E(): 1.7e-09, (40.0% identity in 110 aa overlap); FT Rv1804c, Rv1810, Rv0622, etc." FT /db_xref="InterPro:IPR007969" FT /db_xref="UniProtKB/Swiss-Prot:P0A5E5" FT /protein_id="CAA97761.1" FT /translation="MFTRRFAASMVGTTLTAATLGLAALGFAGTASASSTDEAFLAQLQ FT ADGITPPSAARAIKDAHAVCDALDEGHSAKAVIKAVAKATGLSAKGAKTFAVDAASAYC FT PQYVTSS" FT tRNA complement(63150..63222) FT /gene="tRNA-Arg(CCG)" FT /product="transfer RNA-Arg(CCG)" FT /anticodon=(pos:63187..63189,aa:Arg) FT CDS 63336..64988 FT /transl_table=11 FT /gene="argS" FT /locus_tag="Rv1292" FT /product="PROBABLE ARGINYL-TRNA SYNTHETASE ARGS (ARGRS) FT (Arginine--tRNA ligase)" FT /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC FT ACTIVITY: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate FT + L-arginyl-tRNA(Arg)]." FT /EC_number="6.1.1.19" FT /note="Rv1292, (MTCY373.12), len: 550 aa. Probable argS, FT Arginyl-tRNA synthetase (EC 6.1.1.19), highly similar to FT SYR_MYCLE|P45840 Mycobacterium leprae (550 aa), FASTA FT scores: opt: 3115, E(): 0, (84.9% identity in 550 aa FT overlap). Contains PS00178 Aminoacyl-transfer RNA FT synthetases class-I signature. BELONGS TO CLASS-I FT AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:P67569" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:P67569" FT /protein_id="CAA97757.1" FT /translation="MTPADLAELLKATAAAVLAERGLDASALPQMVTVERPRIPEHGDY FT ASNLAMQLAKKVGTNPRELAGWLAEALTKVDGIASAEVAGPGFINMRLETAAQAKVVTS FT VIDAGHSYGHSLLLAGRKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLTTQGADVVR FT EYYFNDHGAQIDRFANSLIAAAKGEPTPQDGYAGSYITNIAEQVLQKAPDALSLPDAEL FT RETFRAIGVDLMFDHIKQSLHEFGTDFDVYTHEDSMHTGGRVENAIARLRETGNIYEKD FT GATWLRTSAFGDDKDRVVIKSDGKPAYIAGDLAYYLDKRQRGFDLCIYMLGADHHGYIA FT RLKAAAAAFGDDPATVEVLIGQMVNLVRDGQPVRMSKRAGTVLTLDDLVEAIGVDAARY FT SLIRSSVDTAIDIDLALWSSASNENPVYYVQYAHARLSALARNAAELALIPDTNHLELL FT NHDKEGTLLRTLGEFPRVLETAASLREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEQP FT TDLHTARLALCQATRQVIANGLAIIGVTAPERM" FT misc_feature 63729..63758 FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT CDS 64985..66328 FT /transl_table=11 FT /gene="lysA" FT /locus_tag="Rv1293" FT /product="PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP FT DECARBOXYLASE)" FT /function="INVOLVED IN BIOSYNTHESIS OF LYSINE (LAST STEP) FT [CATALYTIC ACTIVITY : MESO-2,6-DIAMINOHEPTANEDIOATE = FT L-LYSINE + CO(2)]." FT /EC_number="4.1.1.20" FT /note="Rv1293, (MTCY373.13), len: 447 aa. Probable lysA, FT diaminopimelate decarboxylase (EC 4.1.1.20) (see citation FT below), almost identical to DCDA_MYCTU|P31848. Contains FT PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P FT attachment site, PS00879 Orn/DAP/Arg decarboxylases family FT 2 signature 2. BELONGS TO FAMILY 2 OF ORNITHINE, DAP, AND FT ARGININE DECARBOXYLASES." FT /db_xref="GOA:P0A5M4" FT /db_xref="InterPro:IPR000183" FT /db_xref="PDB:1HKV" FT /db_xref="UniProtKB/Swiss-Prot:P0A5M4" FT /protein_id="CAA97758.1" FT /translation="MNELLHLAPNVWPRNTTRDEVGVVCIAGIPLTQLAQEYGTPLFVI FT DEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGELAVALHA FT SFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLT FT VGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVD FT GFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAELAAKLGT FT IVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMS FT DNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHCESGDIIVRDTWVPDDIRPGDLVAV FT AATGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRETVDDLLSLEVR" FT misc_feature 65189..65245 FT /note="PS00878 Orn/DAP/Arg decarboxylases family 2 FT pyridoxal-P attachment site" FT misc_feature 65732..65764 FT /note="PS00879 Orn/DAP/Arg decarboxylases family 2 FT signature 2" FT CDS 66332..67657 FT /transl_table=11 FT /gene="thrA" FT /locus_tag="Rv1294" FT /product="PROBABLE HOMOSERINE DEHYDROGENASE THRA" FT /function="INVOLVED IN THE CONVERSION OF L-ASPARTATE TO FT HOMOSERINE (THIRD STEP). HOMOSERINE PARTICIPATES IN THE FT BIOSYNTHESIS OF THREONINE AND THEN ISOLEUCINE AND IN THE FT BIOSYNTHESIS OF METHIONINE [CATALYTIC ACTIVITY : FT L-HOMOSERINE + NAD(P)(+) = L-ASPARTATE 4-SEMIALDEHYDE + FT NAD(P)H.]" FT /EC_number="1.1.1.3" FT /note="Rv1294, (MTCY373.14), len: 441 aa. Probable thrA FT (hom), homoserine dehydrogenase (EC 1.1.1.3), highly FT similar to DHOM_MYCLE|P46806 from Mycobacterium leprae (441 FT aa), FASTA scores: opt: 2437, E():0, (89.5% identity in 438 FT aa overlap). Contains PS00017 ATP/GTP-binding site motif A; FT PS01042 Homoserine dehydrogenase signature. BELONGS TO THE FT HOMOSERINE DEHYDROGENASE FAMILY." FT /db_xref="GOA:P63629" FT /db_xref="InterPro:IPR019811" FT /db_xref="UniProtKB/Swiss-Prot:P63629" FT /protein_id="CAA97759.1" FT /translation="MPGDEKPVGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRG FT IGVRRVTTDRGVPIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVT FT ANKALLATSTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGT FT TNYILSAMDSTGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTA FT DDVYREGITKVTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPL FT AAVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPRESKY FT AQLPVAPMGFIETRYYVSMNVADKPGVLSAVAAEFAKREVSIAEVRQEGVVDEGGRRVG FT ARIVVVTHLATDAALSETVDALDDLDVVQGVSSVIRLEGTGL" FT misc_feature 66611..66634 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 66884..66952 FT /note="PS01042 Homoserine dehydrogenase signature" FT CDS 67654..68736 FT /transl_table=11 FT /gene="thrC" FT /locus_tag="Rv1295" FT /product="PROBABLE THREONINE SYNTHASE THRC" FT /function="INVOLVED IN THREONINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY : O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + FT PHOSPHATE]" FT /EC_number="4.2.3.1" FT /note="Rv1295, (MTCY373.15), len: 360 aa. Probable thrC, FT threonine synthase (EC 4.2.99.2) (see Parish et al., 1999), FT highly similar to THRC_MYCLE|P45837 Mycobacterium leprae FT (360 aa), FASTA scores: opt: 2202, E(): 0, (93.9% identity FT in 359 aa overlap). Contains PS00165 Serine/threonine FT dehydratases pyridoxal-phosphate attachment site." FT /db_xref="GOA:P66902" FT /db_xref="InterPro:IPR004450" FT /db_xref="PDB:2D1F" FT /db_xref="UniProtKB/Swiss-Prot:P66902" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97760.1" FT /translation="MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAAT FT NLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYA FT ARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVN FT SVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPR FT MLGTQAAGAAPLVLGEPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEIL FT AAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDM FT PSVSPVPVDPVAVVEKLGLA" FT misc_feature 67831..67872 FT /note="PS00165 Serine/threonine dehydratases FT pyridoxal-phosphate attachment site" FT CDS 68954..69904 FT /transl_table=11 FT /gene="thrB" FT /locus_tag="Rv1296" FT /product="PROBABLE HOMOSERINE KINASE THRB" FT /function="THREONINE BIOSYNTHESIS FROM ASPARATE (FOURTH FT STEP) [CATALYTIC ACTIVITY : ATP + L-HOMOSERINE = ADP + FT O-PHOSPHO-L-HOMOSERINE]." FT /EC_number="2.7.1.39" FT /note="Rv1296, (MTCY373.16), len: 316 aa. Probable thrB, FT homoserine kinase (EC 2.7.1.39) (see citation below), FT highly similar to KHSE_MYCLE|P45836 from Mycobacterium FT leprae (314 aa), FASTA scores, opt: 1657, E(): 0, (82.0% FT identity in 311 aa overlap). Contains PS00639 Eukaryotic FT thiol (cysteine) proteases histidine active site, and FT PS00627 GHMP kinases putative ATP-binding domain." FT /db_xref="GOA:P65224" FT /db_xref="InterPro:IPR014721" FT /db_xref="UniProtKB/Swiss-Prot:P65224" FT /protein_id="CAA97729.1" FT /translation="MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYDEIIVET FT TDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHGLQAAGVSAAGLAVRCRNAIPHSRGLGS FT SAAAVVGGLAAVNGLVVQTDSSPSSDAELIQLASEFEGHPDNAAAAVLGGAVVSWTDHS FT GDRPNYSAVSLRLHPDIRLFTAIPEQRSSTAETRVLLPAQVSHDDARFNVSRAALLVVA FT LTERPDLLMAATEDLLHQPQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIALSTDSE FT LPTDAVEFGAAKGFAVTELTVGEAVRWSPTVRVPG" FT misc_feature 69173..69205 FT /note="PS00639 Eukaryotic thiol (cysteine) proteases FT histidine active site" FT misc_feature 69239..69274 FT /note="PS00627 GHMP kinases putative ATP-binding domain" FT CDS 70161..71969 FT /transl_table=11 FT /gene="rho" FT /locus_tag="Rv1297" FT /product="PROBABLE TRANSCRIPTION TERMINATION FACTOR RHO FT HOMOLOG" FT /function="FACILITATES TRANSCRIPTION TERMINATION BY A FT MECHANISM THAT INVOLVES RHO BINDING TO THE NASCENT RNA, FT ACTIVATION OF RHO'S RNA-DEPENDENT ATPASE ACTIVITY, AND FT RELEASE OF THE MRNA FROM THE DNA TEMPLATE" FT /note="Rv1297, (MTCY373.17), len: 602 aa. Probable rho, FT transcription termination factor homolog, highly similar to FT many e.g. RHO_MYCLE|P45835 Mycobacterium leprae (610 aa), FT FASTA scores: (81.5% identity in 612 aa overlap). CONTAINS FT 1 RNA RECOGNITION MOTIF (RRM)." FT /db_xref="GOA:P66028" FT /db_xref="HSSP:1PV4" FT /db_xref="InterPro:IPR004665" FT /db_xref="UniProtKB/Swiss-Prot:P66028" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97730.1" FT /translation="MTDTDLITAGESTDGKPSDAAATDPPDLNADEPAGSLATMVLPEL FT RALANRAGVKGTSGMRKNELIAAIEEIRRQANGAPAVDRSAQEHDKGDRPPSSEAPATQ FT GEQTPTEQIDSQSQQVRPERRSATREAGPSGSGERAGTAADDTDNRQGGQQDAKTEERG FT TDAGGDQGGDQQASGGQQARGDEDGEARQGRRGRRFRDRRRRGERSGDGAEAELREDDV FT VQPVAGILDVLDNYAFVRTSGYLPGPHDVYVSMNMVRKNGMRRGDAVTGAVRVPKEGEQ FT PNQRQKFNPLVRLDSINGGSVEDAKKRPEFGKLTPLYPNQRLRLETSTERLTTRVIDLI FT MPIGKGQRALIVSPPKAGKTTILQDIANAITRNNPECHLMVVLVDERPEEVTDMQRSVK FT GEVIASTFDRPPSDHTSVAELAIERAKRLVEQGKDVVVLLDSITRLGRAYNNASPASGR FT ILSGGVDSTALYPPKRFLGAARNIEEGGSLTIIATAMVETGSTGDTVIFEEFKGTGNAE FT LKLDRKIAERRVFPAVDVNPSGTRKDELLLSPDEFAIVHKLRRVLSGLDSHQAIDLLMS FT QLRKTKNNYEFLVQVSKTTPGSMDSD" FT CDS 72120..72362 FT /transl_table=11 FT /gene="rpmE" FT /locus_tag="Rv1298" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L31 RPME" FT /function="INVOLVED IN TRANSLATION" FT /note="Rv1298, (MTCY373.18), len: 80 aa. Probable rpmE, 50s FT ribosomal protein L31, highly similar to many e.g. FT RL31_MYCLE|P45834 50s ribosomal protein L31 from FT Mycobacterium leprae (84 aa), FASTA scores: opt: 490, E(): FT 5.5e-28, (89.6% identity in 77 aa overlap). Contains FT PS01143 Ribosomal protein L31 signature. BELONGS TO THE FT L31P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66187" FT /db_xref="InterPro:IPR002150" FT /db_xref="UniProtKB/Swiss-Prot:P66187" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97731.1" FT /translation="MKSDIHPAYEETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPFY FT TGKQKILDSGGRVARFEKRYGKRKVGADKAVSTGK" FT misc_feature 72231..72269 FT /note="PS01143 Ribosomal protein L31 signature" FT CDS 72452..73525 FT /transl_table=11 FT /gene="prfA" FT /locus_tag="Rv1299" FT /product="PROBABLE PEPTIDE CHAIN RELEASE FACTOR 1 PRFA FT (RF-1)" FT /function="PEPTIDE CHAIN RELEASE FACTOR 1 DIRECTS THE FT TERMINATION OF TRANSLATION IN RESPONSE TO THE PEPTIDE CHAIN FT TERMINATION CODONS UAG AND UAA" FT /note="Rv1299, (MTCY373.19), len: 357 aa. Probable prfA, FT peptide chain release factor 1 (rf-1), highly similar to FT many e.g. RF1_MYCLE|P45833 peptide chain release factor 1 FT (rf-1) from Mycobacterium leprae (357 aa), FASTA scores: FT opt: 2047, E(): 0, (89.3% identity in 356 aa overlap); also FT similar to Mycobacterium tuberculosis Rv3105c, prfB peptide FT chain release factor 2. Contains PS00745 Prokaryotic-type FT class I peptide chain release factors signature. BELONGS TO FT THE PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY." FT /db_xref="GOA:P66016" FT /db_xref="HSSP:1GQE" FT /db_xref="InterPro:IPR004373" FT /db_xref="UniProtKB/Swiss-Prot:P66016" FT /protein_id="CAA97732.1" FT /translation="MTQPVQTIDVLLAEHAELELALADPALHSNPAEARRVGRRFARLA FT PIVATHRKLTSARDDLETARELVASDESFAAEVAALEARVGELDAQLTDMLAPRDPHDA FT DDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWAVTVLDETTSDLGGYKDATLAIA FT SKADTPDGVWSRMKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVGQVQIDESD FT LRIDVFRSSGKGGQGVNTTDSAVRITHLPTGIVVTCQNERSQLQNKTRALQVLAARLQA FT MAEEQALADASADRASQIRTVDRSERIRTYNFPENRITDHRIGYKSHNLDQVLDGDLDA FT LFDALSAADKQSRLRQS" FT misc_feature 73136..73186 FT /note="PS00745 Prokaryotic-type class I peptide chain FT release factors signature" FT CDS 73522..74499 FT /transl_table=11 FT /gene="hemK" FT /locus_tag="Rv1300" FT /product="PROBABLE HEMK PROTEIN HOMOLOG HEMK" FT /function="POSSIBLY INVOLVED IN THE OXIDATION OF FT PROTOPORPHYRINOGEN INTO PROTOPORPHYRIN IX" FT /EC_number="2.1.1.-" FT /note="Rv1300, (MTCY373.20), len: 325 aa. Probable hemK FT protein homolog (EC 2.1.1.-), homology suggests translation FT may start at aa 22, highly similar to many e.g. FT HEMK_MYCLE|P45832 Mycobacterium leprae (288 aa), FASTA FT scores: opt: 936, E(): 0, (76.7% identity in 189 aa FT overlap). BELONGS TO THE HEMK FAMILY OF MODIFICATION FT METHYLASES." FT /db_xref="GOA:Q10602" FT /db_xref="InterPro:IPR007848" FT /db_xref="UniProtKB/Swiss-Prot:Q10602" FT /protein_id="CAA97733.1" FT /translation="MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARC FT DAEQLAAHLAGTDRGRLPLFEPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLH FT VGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALAQHRANLGLKARIIG FT IDDSDCALDYARRNAAGTPVELVRADVTTPRLLPELDGQVDLMVSNPPYIPDAAVLEPE FT VAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLF FT VDVQARKDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR" FT repeat_region 73542..73584 FT /note="43 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT repeat_region 74410..74461 FT /note="52 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT repeat_region 74462..74514 FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 74515..75168 FT /transl_table=11 FT /locus_tag="Rv1301" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1301, (MTCY373.21), len: 217 aa. Conserved FT hypothetical protein, highly similar to YRFE_MYCLE|P45831 FT hypothetical 22.7 kDa protein in rfe-hemk intergenic FT region, (220 aa), FASTA scores: opt: 1168, E(): 0, (82.8% FT identity in 215 aa overlap). Contains PS01147 Hypothetical FT SUA5/yciO/yrdC family signature. BELONGS TO THE FT SUA5/YRDC/YCIO/YWLC FAMILY." FT /db_xref="HSSP:1JCU" FT /db_xref="InterPro:IPR006070" FT /db_xref="UniProtKB/Swiss-Prot:Q10618" FT /protein_id="CAA97734.1" FT /translation="MTETFDCADPEQRSRGIVSAVGAIKAGQLVVMPTDTVYGIGADAF FT DSSAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYSMPDGARELIRAFWPGALSLVVVQ FT APSLQWDLGDAHGTVMLRMPLHPVAIELLREVGPMAVSSANISGHPPPVDAEQARSQLG FT DHVAVYLDAGPSEQQAGSTIVDLTGATPRVLRPGPVSTERIAEVLGVDAASLFG" FT misc_feature 74599..74637 FT /note="PS01147 Hypothetical SUA5/yciO/yrdC family FT signature" FT CDS 75252..76466 FT /transl_table=11 FT /gene="rfe" FT /locus_tag="Rv1302" FT /standard_name="wecA" FT /product="PROBABLE UNDECAPAPRENYL-PHOSPHATE FT ALPHA-N-ACETYLGLUCOSAMINYLTRANSFERASE RFE (UDP-GlcNAc FT TRANSFERASE)" FT /function="THOUGHT TO BE INVOLVED IN AG BIOSYNTHESIS. MAY FT BE THE TUNICAMYCIN SENSITIVE TRANSFERASE THAT CATALYZES THE FT SYNTHESIS OF GLCNAC-PYROPHOSPHORYLUNDECAPRENOL (LIPID I), FT THE FIRST LIPID-LINKED INTERMEDIATE INVOLVED IN ECA FT SYNTHESIS." FT /EC_number="2.4.1.-" FT /note="Rv1302, (MTCY373.22), len: 404 aa. Probable rfe FT (alternate gene name: wecA), undecaprenyl-phosphate FT alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-) (see FT citation below), equivalent to RFE_MYCLE|P45830 FT Mycobacterium leprae (398 aa), FASTA scores, opt: 2285, FT E(): 0, (89.2% identity in 398 aa overlap)." FT /db_xref="GOA:Q10606" FT /db_xref="InterPro:IPR018481" FT /db_xref="UniProtKB/Swiss-Prot:Q10606" FT /protein_id="CAA97735.1" FT /translation="MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITY FT FATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGLAMFLGIVGAVFLASQLPALTRGFV FT YSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPVGG FT VGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHG FT GDVLYYPPAVISVVLAGACLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQ FT NAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRAGRSAFSPDKMHLHHRLLQIG FT HSHRRVVLIIYLWVGIVAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYY FT DPDLD" FT CDS 76723..77208 FT /transl_table=11 FT /locus_tag="Rv1303" FT /product="CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1303, (MTCY373.23), len: 161 aa. Conserved FT hypothetical transmembrane protein, highly similar to FT P53431|Y02N_MYCLE hypothetical Mycobacterium leprae protein FT (153 aa), FASTA score: opt: 636, E():0, (69.8% identity in FT 149 aa overlap)." FT /db_xref="GOA:P64801" FT /db_xref="InterPro:IPR008413" FT /db_xref="UniProtKB/Swiss-Prot:P64801" FT /protein_id="CAA97736.1" FT /translation="MTTPAQDAPLVFPSVAFRPVRLFFINVGLAAVAMLVAGVFGHLTV FT GMFLGLGLLLGLLNALLVRRSAESITAKEHPLKRSMALNSASRLAIITILGLIIAYIFR FT PAGLGVVFGLAFFQVLLVATTALPVLKKLRTATEEPVATYSSNGQTGGSEGRSASDD" FT CDS 77201..77953 FT /transl_table=11 FT /gene="atpB" FT /locus_tag="Rv1304" FT /product="PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6)" FT /function="KEY COMPONENT OF THE PROTON CHANNEL; IT MAY PLAY FT A DIRECT ROLE IN THE TRANSLOCATION OF PROTONS (H+) ACROSS FT THE MEMBRANE" FT /EC_number="3.6.3.14" FT /note="Rv1304, (MTCY373.24), len: 250 aa. Probable atpB, FT ATP synthase A chain (EC 3.6.3.14), highly similar to FT ATP6_MYCLE|P45829 Mycobacterium leprae (251 aa), FASTA FT scores: opt: 1382, E(): 0, (84.0% identity in 250 aa FT overlap). Contains PS00449 ATP synthase A subunit FT signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) FT - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON FT CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), FT GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN FT SUBUNITS: A, B AND C. BELONGS TO THE ATPASE A CHAIN FT FAMILY." FT /db_xref="GOA:P63654" FT /db_xref="HSSP:1C17" FT /db_xref="InterPro:IPR000568" FT /db_xref="UniProtKB/Swiss-Prot:P63654" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97737.1" FT /translation="MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAF FT YLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISNWL FT AVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLLKG FT HVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLF FT VGAIQAFIFALLTILYFSQAMELEEEHH" FT misc_feature 77744..77773 FT /note="PS00449 ATP synthase a subunit signature" FT CDS 78002..78247 FT /transl_table=11 FT /gene="atpE" FT /locus_tag="Rv1305" FT /product="PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING FT PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN)" FT /function="THIS IS ONE OF THE THREE CHAINS OF THE FT NONENZYMATIC COMPONENT (CF(0) SUBUNIT) OF THE ATPASE FT COMPLEX." FT /EC_number="3.6.3.14" FT /note="Rv1305, (MTCY373.25), len: 81 aa. Probable atpE, ATP FT synthase C chain (EC 3.6.3.14), highly similar to FT P45828|ATPL_MYCLE Mycobacterium leprae (92.6% identity in FT 81 aa overlap). Contains PS00605 ATP synthase C subunit FT signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) FT - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON FT CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), FT GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN FT SUBUNITS: A, B AND C. BELONGS TO THE ATPASE C CHAIN FT FAMILY." FT /db_xref="GOA:P63691" FT /db_xref="InterPro:IPR002379" FT /db_xref="UniProtKB/Swiss-Prot:P63691" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97738.1" FT /translation="MDPTIAAGALIGGGLIMAGGAIGAGIGDGVAGNALISGVARQPEA FT QGRLFTPFFITVGLVEAAYFINLAFMALFVFATPVK" FT misc_feature 78119..78184 FT /note="PS00605 ATP synthase c subunit signature" FT CDS 78278..78793 FT /transl_table=11 FT /gene="atpF" FT /locus_tag="Rv1306" FT /product="PROBABLE ATP SYNTHASE B CHAIN ATPF" FT /function="THIS IS ONE OF THE THREE CHAINS OF THE FT NONENZYMATIC COMPONENT (CF(0) SUBUNIT) OF THE ATPASE FT COMPLEX." FT /EC_number="3.6.3.14" FT /note="Rv1306, (MTCY373.26), len: 171 aa. Probable atpF, FT ATP synthase B chain (EC 3.6.3.14), highly similar to FT ATPF_MYCLE P45827 (170 aa), FASTA scores, opt: 802, E(): 0, FT (79.5% identity in 171 aa overlap). SUBUNIT: F-TYPE ATPASES FT HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - FT THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: FT ALPHA(3), BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) FT HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE FT B CHAIN FAMILY." FT /db_xref="GOA:P63656" FT /db_xref="InterPro:IPR002146" FT /db_xref="UniProtKB/Swiss-Prot:P63656" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97739.1" FT /translation="MGEVSAIVLAASQAAEEGGESSNFLIPNGTFFVVLAIFLVVLAVI FT GTFVVPPILKVLRERDAMVAKTLADNKKSDEQFAAAQADYDEAMTEARVQASSLRDNAR FT ADGRKVIEDARVRAEQQVASTLQTAHEQLKRERDAVELDLRAHVGTMSATLASRILGVD FT LTASAATR" FT CDS 78800..80140 FT /transl_table=11 FT /gene="atpH" FT /locus_tag="Rv1307" FT /product="PROBABLE ATP SYNTHASE DELTA CHAIN ATPH" FT /function="THIS PROTEIN SEEMS TO BE PART OF THE STALK THAT FT LINKS CF(0) TO CF(1). IT EITHER TRANSMITS CONFORMATIONAL FT CHANGES FROM CF(0) INTO CF(1) OR IS IMPLICATED IN PROTON FT CONDUCTION [CATALYTIC ACTIVITY : ATP + H(2)O + H(+)(IN) = FT ADP + PHOSPHATE + H(+)(OUT)]" FT /EC_number="3.6.3.14" FT /note="Rv1307, (MTCY373.27), len: 446 aa. Probable atpH, FT ATP synthase delta chain (EC 3.6.3.14). This protein is FT much longer than that of other bacterial delta chains, the FT C-terminal region is homologous to delta chains while the FT N-terminal region is similar to B/B' subunits e.g. FT ATPD_STRLI|P50008 ATP synthase delta chain from FT Streptomyces lividans (273 aa), FASTA scores: opt: 505, FT E(): 5.4e-23, (35.0% identity in 277 aa overlap); and FT ATPF_HAEIN|P43720 ATP synthase B chain (EC 3.6.1.34) from FT Haemophilus influenzae (156 aa), FASTA scores: opt: 216, FT E(): 1.2e-06, (26.1% identity in 153 aa overlap). SUBUNIT: FT F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC FT CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FT FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), FT EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. FT BELONGS TO THE ATPASE DELTA CHAIN FAMILY." FT /db_xref="GOA:P0A500" FT /db_xref="InterPro:IPR000711" FT /db_xref="UniProtKB/Swiss-Prot:P0A500" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97740.1" FT /translation="MSTFIGQLFGFAVIVYLVWRFIVPLVGRLMSARQDTVRQQLADAA FT AAADRLAEASQAHTKALEDAKSEAHRVVEEARTDAERIAEQLEAQADVEAERIKMQGAR FT QVDLIRAQLTRQLRLELGHESVRQARELVRNHVADQAQQSATVDRFLDQLDAMAPATAD FT VDYPLLAKMRSASRRALTSLVDWFGTMAQDLDHQGLTTLAGELVSVARLLDREAVVTRY FT LTVPAEDATPRIRLIERLVSGKVGAPTLEVLRTAVSKRWSANSDLIDAIEHVSRQALLE FT LAERAGQVDEVEDQLFRFSRILDVQPRLAILLGDCAVPAEGRVRLLRKVLERADSTVNP FT VVVALLSHTVELLRGQAVEEAVLFLAEVAVARRGEIVAQVGAAAELSDAQRTRLTEVLS FT RIYGHPVTVQLHIDAALLGGLSIAVGDEVIDGTLSSRLAAAEARLPD" FT CDS 80185..81834 FT /transl_table=11 FT /gene="atpA" FT /locus_tag="Rv1308" FT /product="PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA" FT /function="PRODUCES ATP FROM ADP IN THE PRESENCE OF A FT PROTON GRADIENT ACROSS THE MEMBRANE. THE ALPHA CHAIN IS A FT REGULATORY SUBUNIT [CATALYTIC ACTIVITY:ATP + H(2)O + FT H(+)(IN) = ADP + PHOSPHATE + H(+)(OUT)]" FT /EC_number="3.6.3.14" FT /note="Rv1308, (MTCY373.28), len: 549 aa. Probable atpA, FT ATP synthase alpha chain (EC 3.6.3.14), highly similar to FT ATPA_MYCLE|P45825 from Mycobacterium leprae (558 aa), FASTA FT scores: opt: 3233, E(): 0, (90.3% identity in 547 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A, FT PS00152 ATP synthase alpha and beta subunits signature. FT SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE FT CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. FT CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), FT DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B FT AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY." FT /db_xref="GOA:P63673" FT /db_xref="InterPro:IPR000194" FT /db_xref="UniProtKB/Swiss-Prot:P63673" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97741.1" FT /translation="MAELTIPADDIQSAIEEYVSSFTADTSREEVGTVVDAGDGIAHVE FT GLPSVMTQELLEFPGGILGVALNLDEHSVGAVILGDFENIEEGQQVKRTGEVLSVPVGD FT GFLGRVVNPLGQPIDGRGDVDSDTRRALELQAPSVVHRQGVKEPLQTGIKAIDAMTPIG FT RGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDPKKQVRCVYVAIGQKGTTIAAVRRT FT LEEGGAMDYTTIVAAAASESAGFKWLAPYTGSAIAQHWMYEGKHVLIIFDDLTKQAEAY FT RAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDDLGGGSLTGLPIIETKANDISAY FT IPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQ FT YRELEAFAAFASDLDAASKAQLERGARLVELLKQPQSQPMPVEEQVVSIFLGTGGHLDS FT VPVEDVRRFETELLDHMRASEEEILTEIRDSQKLTEEAADKLTEVIKNFKKGFAATGGG FT SVVPDEHVEALDEDKLAKEAVKVKKPAPKKKK" FT misc_feature 80698..80721 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 81280..81309 FT /note="PS00152 ATP synthase alpha and beta subunits FT signature" FT CDS 81841..82758 FT /transl_table=11 FT /gene="atpG" FT /locus_tag="Rv1309" FT /product="PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG" FT /function="PRODUCES ATP FROM ADP IN THE PRESENCE OF A FT PROTON GRADIENT ACROSS THE MEMBRANE. THE GAMMA CHAIN IS FT BELIEVED TO BE IMPORTANT IN REGULATING ATPASE ACTIVITY AND FT THE FLOW OF PROTONS THROUGH THE CF(0) COMPLEX." FT /EC_number="3.6.3.14" FT /note="Rv1309, (MTCY373.29), len: 305 aa. Probable atpG, FT ATP synthase gamma chain (EC 3.6.3.14), highly similar to FT ATPG_MYCLE|P45824 ATP synthase gamma chain from FT Mycobacterium leprae (298 aa), FASTA scores: opt: 1579, FT E():0, (83.9% identity in 305 aa overlap). Contains PS00153 FT ATP synthase gamma subunit signature. SUBUNIT: F-TYPE FT ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND FT CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE FT SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), FT EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. FT BELONGS TO THE ATPASE GAMMA CHAIN FAMILY." FT /db_xref="GOA:P63671" FT /db_xref="HSSP:1FS0" FT /db_xref="InterPro:IPR000131" FT /db_xref="UniProtKB/Swiss-Prot:P63671" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97742.1" FT /translation="MAATLRELRGRIRSAGSIKKITKAQELIATSRIARAQARLESARP FT YAFEITRMLTTLAAEAALDHPLLVERPEPKRAGVLVVSSDRGLCGAYNANIFRRSEELF FT SLLREAGKQPVLYVVGRKAQNYYSFRNWNITESWMGFSEQPTYENAAEIASTLVDAFLL FT GTDNGEDQRSDSGEGVDELHIVYTEFKSMLSQSAEAHRIAPMVVEYVEEDIGPRTLYSF FT EPDATMLFESLLPRYLTTRVYAALLESAASELASRQRAMKSATDNADDLIKALTLMANR FT ERQAQITQEISEIVGGANALAEAR" FT misc_feature 82699..82740 FT /note="PS00153 ATP synthase gamma subunit signature" FT CDS 82798..84258 FT /transl_table=11 FT /gene="atpD" FT /locus_tag="Rv1310" FT /product="PROBABLE ATP SYNTHASE BETA CHAIN ATPD" FT /function="PRODUCES ATP FROM ADP IN THE PRESENCE OF A FT PROTON GRADIENT ACROSS THE MEMBRANE. THE BETA CHAIN IS THE FT CATALYTIC SUBUNIT [CATALYTIC ACTIVITY : ATP + H(2)O + FT H(+)(IN) = ADP + PHOSPHATE + H(+)(OUT)]" FT /EC_number="3.6.3.14" FT /note="Rv1310, (MTCY373.30), len: 486 aa. Probable atpD, FT ATP synthase beta chain (EC 3.6.3.14), highly similar to FT ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa), FASTA FT score: opt: 2916, E(): 0, (92.6% identity in 484 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A, FT PS00152 ATP synthase alpha and beta subunits signature. FT SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE FT CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. FT CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), FT DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B FT AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY." FT /db_xref="GOA:P63677" FT /db_xref="HSSP:1SKY" FT /db_xref="InterPro:IPR000194" FT /db_xref="UniProtKB/Swiss-Prot:P63677" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97743.1" FT /translation="MTTTAEKTDRPGKPGSSDTSGRVVRVTGPVVDVEFPRGSIPELFN FT ALHAEITFESLAKTLTLEVAQHLGDNLVRTISLQPTDGLVRGVEVIDTGRSISVPVGEG FT VKGHVFNALGDCLDEPGYGEKFEHWSIHRKPPAFEELEPRTEMLETGLKVVDLLTPYVR FT GGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELAEANVLK FT DTALVFGQMDEPPGTRMRVALSALTMAEWFRDEQGQDVLLFIDNIFRFTQAGSEVSTLL FT GRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDA FT TTELSRAVFSKGIFPAVDPLASSSTILDPSVVGDEHYRVAQEVIRILQRYKDLQDIIAI FT LGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIEAFDRLCKGDF FT DHVPEQAFFLIGGLDDLAKKAESLGAKL" FT misc_feature 83308..83331 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 83860..83889 FT /note="PS00152 ATP synthase alpha and beta subunits FT signature" FT CDS 84272..84637 FT /transl_table=11 FT /gene="atpC" FT /locus_tag="Rv1311" FT /product="PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC" FT /function="PRODUCES ATP FROM ADP IN THE PRESENCE OF A FT PROTON GRADIENT ACROSS THE MEMBRANE [CATALYTIC ACTIVITY : FT ATP + H(2)O + H(+)(IN) = ADP + PHOSPHATE + H(+)(OUT)]" FT /EC_number="3.6.3.14" FT /note="Rv1311, (MTCY373.31), len: 121 aa. Probable atpC, FT ATP synthase epsilon chain (EC 3.6.3.14), highly similar to FT ATPE_MYCLE|P45822 Mycobacterium leprae (124 aa), FASTA FT scores: opt: 682, E(): 5.4e-40, (87.6% identity in 121 aa FT overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) FT - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON FT CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), FT GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN FT SUBUNITS: A, B AND C. BELONGS TO THE ATPASE EPSILON CHAIN FT FAMILY." FT /db_xref="GOA:P63662" FT /db_xref="InterPro:IPR001469" FT /db_xref="UniProtKB/Swiss-Prot:P63662" FT /protein_id="CAA97744.1" FT /translation="MAELNVEIVAVDRNIWSGTAKFLFTRTTVGEIGILPRHIPLVAQL FT VDDAMVRVEREGEKDLRIAVDGGFLSVTEEGVSILAESAEFESEIDEAAAKQDSESDDP FT RIAARGRARLRAVGAID" FT CDS 84645..85088 FT /transl_table=11 FT /locus_tag="Rv1312" FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv1312, (MTCY373.32), len: 147 aa. Conserved FT hypothetical secreted protein with potential N-terminal FT signal sequence. Highly similar to P53432|Y02W_MYCLE FT hypothetical Mycobacterium leprae protein (147 aa), FASTA FT score: opt: 884, E(): 0, (88.4% identity in 147 aa FT overlap). N-terminus hydrophobic." FT /db_xref="GOA:Q10620" FT /db_xref="InterPro:IPR019675" FT /db_xref="UniProtKB/Swiss-Prot:Q10620" FT /protein_id="CAA97745.1" FT /translation="MSAPMIGMVVLVVVLGLAVLALSYRLWKLRQGGTAGIMRDIPAVG FT GHGWRHGVIRYRGGEAAFYRLSSLRLWPDRRLSRRGVEIISRRAPRGDEFDIMTDEIVV FT VELCDSTQDRRVGYEIALDRGALTAFLSWLESRPSPRARRRSM" FT repeat_region 85100..85118 FT /note="19 bp inverted repeat, GCAGACGCAAAAGCCCCCA, at the FT left end of IS1557" FT repeat_region complement(85100..86608) FT /mobile_element="insertion sequence:IS1557-2" FT /note="IS1557-2, len: 1509 bp. Insertion sequence IS1557." FT CDS complement(85128..86462) FT /transl_table=11 FT /locus_tag="Rv1313c" FT /product="POSSIBLE TRANSPOSASE" FT /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE FT INSERTION ELEMENT IS1557." FT /note="Rv1313c, (MTCY373.33c), len: 444 aa. Possible IS1557 FT transposase, similar to several transposases e.g. FT U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium FT DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% FT identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase FT for insertion sequence element IS1001 from Bordetella FT parapertussis (406 aa), FASTA scores: opt: 254, E(): FT 3.3e-10, (24.9% identity in 402 aa overlap). Also similar FT to putative Mycobacterium tuberculosis transposases, Rv3798 FT and Rv0741." FT /db_xref="GOA:Q10621" FT /db_xref="InterPro:IPR002560" FT /db_xref="UniProtKB/Swiss-Prot:Q10621" FT /protein_id="CAA97746.1" FT /translation="MRNVRLFRALLGVDKRTVIEDIEFEEDDAGDGARVIARVRPRSAV FT LRRCGRCGRKASWYDRGAGLRQWRSLDWGTVEVFLEAEAPRVNCPTHGPTVVAVPWARH FT HAGHTYAFDDTVAWLAVACSKTAVCELMRIAWRTVGAIVARVWADTEKRIDRFANLRRI FT GIDEISYKRHHRYLTVVVDHDSGRLVWAAPGHDKATLGLFFDALGAERAAQITHVSADA FT ADWIADVVTERCPDAIQCADPFHVVAWATEALDVERRRAWNDARAIARTEPKWGRGRPG FT KNAAPRPGRERARRLKGARYALWKNPEDLTERQSAKLAWIAKTDPRLYRAYLLKESLRH FT VFSVKGEEGKQALDRWISWAQRCRIPVFVELAARIKRHRVAIDAALDHGLSQGLIESTN FT TKIRLLTRIAFGFRSPQALIALAMLTLAGHRPTLPGRHNHPQISQ" FT repeat_region complement(86590..86608) FT /note="19 bp inverted repeat, GCAGACGCGAAAGCCCCCA, at the FT right end of IS1557. Single base difference at 3-end." FT CDS complement(86628..87209) FT /transl_table=11 FT /locus_tag="Rv1314c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1314c, (MTCY373.34c), len: 193 aa. Conserved FT hypothetical protein, highly similar to P53523|Y02Y_MYCLE FT hypothetical Mycobacterium leprae protein (191 aa), FASTA FT score: opt:1019, E(): 0, (81.2% identity in 191 aa FT overlap). Some similarity with YDHW_CITFR|P45515 FT hypothetical 19.8 kDa protein in dhar-dhat intergenic FT region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, FT (37.6% identity in 178 aa overlap). Also similar to FT hypothetical protein AE002007|AE002007_3 Deinococcus FT radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, FT (42.4% identity in 172 aa overlap)." FT /db_xref="GOA:P64803" FT /db_xref="InterPro:IPR002779" FT /db_xref="PDB:2G2D" FT /db_xref="UniProtKB/Swiss-Prot:P64803" FT /protein_id="CAA97747.1" FT /translation="MAVHLTRIYTRTGDDGTTGLSDMSRVAKTDARLVAYADCDEANAA FT IGAALALGHPDTQITDVLRQIQNDLFDAGADLSTPIVENPKHPPLRIAQSYIDRLEGWC FT DAYNAGLPALKSFVLPGGSPLSALLHVARTVVRRAERSAWAAVDAHPEGVSVLPAKYLN FT RLSDLLFILSRVANPDGDVLWRPGGDRTAS" FT CDS 87278..88534 FT /transl_table=11 FT /gene="murA" FT /locus_tag="Rv1315" FT /product="PROBABLE UDP-N-ACETYLGLUCOSAMINE FT 1-CARBOXYVINYLTRANSFERASE MURA" FT /function="INVOLVED IN CELL WALL FORMATION; PEPTIDOGLYCAN FT BIOSYNTHESIS. ADDS ENOLPYRUVYL TO UDP-N-ACETYLGLUCOSAMINE FT [CATALYTIC ACTIVITY: PHOSPHOENOLPYRUVATE + UDP-N-ACETYL-D- FT GLUCOSAMINE = PHOSPHATE + FT UDP-N-ACETYL-3-O-(1-CARBOXYVINYL)-D-GLUCOSAMINE]" FT /EC_number="2.5.1.7" FT /note="Rv1315, (MTCY373.35-MTCY149.01), len: 418 aa. FT Probable murA, UDP-N-acetylglucosamine FT 1-carboxyvinyltransferase (EC 2.5.1.7) (see Belanger & FT Inamine 2000), highly similar to many e.g. FT MURA_MYCLE|P45821 (418 aa), FASTA scores: opt: 2495, E(): FT 0, (96.2% identity in 396 aa overlap). BELONGS TO THE EPSP FT SYNTHASE FAMILY. MURA SUBFAMILY." FT /db_xref="GOA:P0A5L2" FT /db_xref="HSSP:1UAE" FT /db_xref="InterPro:IPR005750" FT /db_xref="UniProtKB/Swiss-Prot:P0A5L2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA97748.1" FT /translation="MAERFVVTGGNRLSGEVAVGGAKNSVLKLMAATLLAEGTSTITNC FT PDILDVPLMAEVLRGLGATVELDGDVARITAPDEPKYDADFAAVRQFRASVCVLGPLVG FT RCKRARVALPGGDAIGSRPLDMHQAGLRQLGAHCNIEHGCVVARAETLRGAEIQLEFPS FT VGATENILMAAVVAEGVTTIHNAAREPDVVDLCTMLNQMGAQVEGAGSPTMTITGVPRL FT HPTEHRVIGDRIVAATWGIAAAMTRGDISVAGVDPAHLQLVLHKLHDAGATVTQTDASF FT RVTQYERPKAVNVATLPFPGFPTDLQPMAIALASIADGTSMITENVFEARFRFVEEMIR FT LGADARTDGHHAVVRGLPQLSSAPVWCSDIRAGAGLVLAGLVADGDTEVHDVFHIDRGY FT PLFVENLVSLGAEIERVCC" FT rRNA 88803..90339 FT /gene="rrs" FT /product="ribosomal RNA 16S" FT /note="rrs (alternate gene name: rrnS), len: 1537 nt. 16s FT rRNA gene." FT rRNA 90615..93752 FT /gene="rrl" FT /product="ribosomal RNA 23S" FT /note="rrl, len: 3138 nt. 23S rRNA gene (approximate FT coordinates)." FT rRNA 93856..93970 FT /gene="rrf" FT /product="ribosomal RNA 5S" FT /note="rrf, len: 115 nt. 5S rRNA gene. Identical to FT Em_ba:MT5SRR, D10035 M.tuberculosis 5S rRNA." FT CDS complement(94091..94588) FT /transl_table=11 FT /gene="ogt" FT /locus_tag="Rv1316c" FT /product="PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE FT METHYLTRANSFERASE OGT (6-O-methylguanine-DNA FT methyltransferase) FT (O-6-methylguanine-DNA-alkyltransferase)" FT /function="REPAIR OF ALKYLATED GUANINE IN DNA BY FT STOICHIOMETRICALLY TRANSFERRING THE ALKYL GROUP AT THE O-6 FT POSITION TO A CYSTEINE RESIDUE IN THE ENZYME. THIS IS A FT SUICIDE REACTION: THE ENZYME IS IRREVERSIBLY INACTIVATED FT [CATALYTIC ACTIVITY : DNA (CONTAINING 6-O-METHYLGUANINE) + FT [PROTEIN]-L-CYSTEINE = DNA (WITHOUT 6-O-METHYLGUANINE) + FT PROTEIN S-METHYL-L-CYSTEINE.]" FT /EC_number="2.1.1.63" FT /note="Rv1316c, (MTCY130.01c), len: 165 aa. Probable ogt, FT methylated-dna--protein-cysteine methytransferase (EC FT 2.1.1.63) (see citation below), similar to many e.g. FT OGT_HAEIN|P44687 Haemophilus influenzae (190 aa), FASTA FT scores: opt: 405, E(): 6.5e-20, (41.9% identity in 155 aa FT overlap). Contains PS00374 Methylated-DNA--protein-cysteine FT methyltransferase active site." FT /db_xref="GOA:P0A696" FT /db_xref="HSSP:1SFE" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P0A696" FT /protein_id="CAA98103.1" FT /translation="MIHYRTIDSPIGPLTLAGHGSVLTNLRMLEQTYEPSRTHWTPDPG FT AFSGAVDQLNAYFAGELTEFDVELDLRGTDFQQRVWKALLTIPYGETRSYGEIADQIGA FT PGAARAVGLANGHNPIAIIVPCHRVIGASGKLTGYGGGINRKRALLELEKSRAPADLTL FT FD" FT misc_feature complement(94199..94219) FT /note="PS00374 Methylated-DNA--protein-cysteine FT methyltransferase active site" FT CDS complement(94585..96075) FT /transl_table=11 FT /gene="alkA" FT /locus_tag="Rv1317c" FT /standard_name="ada" FT /product="PROBABLE ADA REGULATORY PROTEIN ALKA (Regulatory FT protein of adaptative response) FT (Methylated-DNA--protein-cysteine methyltransferase) FT (O-6-methylguanine-DNA alkyltransferase) FT (O-6-methylguanine-DNA methyltransferase) (3-methyladenine FT DNA glycosylase II)" FT /function="INVOLVED IN DAMAGE REVERSAL AND IN BASE EXCISION FT REPAIR. THE METHYLATED ADA PROTEIN ACTS AS A POSITIVE FT REGULATOR OF ITS OWN SYNTHESIS, AS WELL AS THAT OF OTHER FT PROTEINS. THE TRANSCRIPTION-ACTIVATING FUNCTION OF THE ADA FT PROTEIN RESIDES IN ITS N-TERMINUS. REPAIR OF ALKYLATED FT GUANINE IN DNA BY STOICHIOMETRICALLY TRANSFERRING THE ALKYL FT GROUP AT THE O-6 POSITION TO A CYSTEINE RESIDUE IN THE FT ENZYME. THIS IS A SUICIDE REACTION: THE ENZYME IS FT IRREVERSIBLY INACTIVATED. CAN ALSO REPAIR O-4-METHYLTHYMINE FT [CATALYTIC ACTIVITY: DNA (CONTAINING 6-O-METHYLGUANINE) + FT [PROTEIN]-L-CYSTEINE = DNA (WITHOUT 6-O-METHYLGUANINE) + FT PROTEIN S-METHYL-L-CYSTEINE]" FT /EC_number="2.1.1.63" FT /note="Rv1317c, (MTCY130.02c), len: 496 aa. Probable alkA FT (alternate gene name: ada), regulatory protein (EC FT 2.1.1.63) (see citation below), similar to FT 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from FT Escherichia coli (282 aa), FASTA scores, opt: 437, E(): FT 8.6e-22, (32.8% identity in 293 aa overlap), also similar FT to other ada proteins e.g. ADA_SALTY|P26189 Salmonella FT typhimurium (352 aa), FASTA scores: E(): 5.3e-08, (35.9% FT identity in 156 aa overlap). Contains PS00041 Bacterial FT regulatory proteins, araC family signature." FT /db_xref="GOA:Q10630" FT /db_xref="HSSP:1ADN" FT /db_xref="InterPro:IPR018060" FT /db_xref="UniProtKB/Swiss-Prot:Q10630" FT /protein_id="CAA98104.1" FT /translation="MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFA FT RNVRFLPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDRDGVS FT GLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNLPFGDVAFAAGFSS FT IRQFNDTVRLACDGTPTALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLAAT FT AVPGCEEVRDGAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLD FT LDADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAG FT RLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVL FT DAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAAKKLGLPAQRR FT ALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQEKIA" FT misc_feature complement(95539..95667) FT /note="PS00041 Bacterial regulatory proteins, araC family FT signature" FT CDS complement(96156..97781) FT /transl_table=11 FT /locus_tag="Rv1318c" FT /product="POSSIBLE ADENYLATE CYCLASE (ATP FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)" FT /function="THOUGHT TO PLAY AN ESSENTIAL ROLES IN REGULATION FT OF CELLULAR METABOLISM BY CATALYSING THE SYNTHESIS OF A FT SECOND MESSENGER, CAMP [CATALYTIC ACTIVITY: ATP = FT 3',5'-CYCLIC AMP + PYROPHOSPHATE]." FT /EC_number="4.6.1.1" FT /note="Rv1318c, (MTCY130.03c), len: 541 aa. Possible FT adenylate cyclase (EC 4.6.1.1). Some similarity at the FT c-terminus to CYAA_RHIME|P19485 adenylate cyclase from FT Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): FT 2.5e-11, (28.8% identity in 184 aa overlap); similar to FT other mycbacterium tuberculosis putative adenylate cyclases FT e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505, FT E(): 0, (71.0% identity in 534 aa overlap), also similar to FT Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E(): FT 0, (68.7% identity in 534 aa overlap). N-terminus is FT hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY." FT /db_xref="GOA:P63527" FT /db_xref="HSSP:1AWL" FT /db_xref="InterPro:IPR003660" FT /db_xref="UniProtKB/Swiss-Prot:P63527" FT /protein_id="CAA98105.1" FT /translation="MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRR FT RRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALA FT LGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGL FT INNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMV FT VWLLGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTAT FT PVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGR FT EVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDR FT HHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQV FT IAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGR FT HVKLRGHDQPVRLAKPVGLTKPRR" FT CDS complement(97851..99458) FT /transl_table=11 FT /locus_tag="Rv1319c" FT /product="POSSIBLE ADENYLATE CYCLASE (ATP FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)" FT /function="THOUGHT TO PLAY AN ESSENTIAL ROLES IN REGULATION FT OF CELLULAR METABOLISM BY CATALYSING THE SYNTHESIS OF A FT SECOND MESSENGER, CAMP [CATALYTIC ACTIVITY: ATP = FT 3',5'-CYCLIC AMP + PYROPHOSPHATE]." FT /EC_number="4.6.1.1" FT /note="Rv1319c, (MTCY130.04c), len: 535 aa. Possible FT adenylate cyclase (EC 4.6.1.1). Some similarity at the FT C-terminus to CYAA_RHIME|P19485 adenylate cyclase from FT Rhizobium meliloti (193 aa), FASTA scores: opt: 254, E(): FT 2.4e-10, (33.3% identity in 144 aa overlap); similar to FT other mycbacterium tuberculosis putative adenylate cyclases FT e.g. Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2505, FT E(): 0, (71.0% identity in 534 aa overlap); FT Rv1320c|MTCY130.05c (567 aa), FASTA scores: opt: 2354, E(): FT 0, (66.3% identity in 534 aa overlap). N-terminus is FT hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY." FT /db_xref="GOA:P0A4Y2" FT /db_xref="InterPro:IPR003660" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Y2" FT /protein_id="CAA98106.1" FT /translation="MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSR FT RWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALA FT IGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYG FT LANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTM FT TVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTA FT APVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVG FT REVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVD FT RHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQ FT IVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLG FT ETVTLRGHEQPTRLAVPT" FT CDS complement(99471..101174) FT /transl_table=11 FT /locus_tag="Rv1320c" FT /product="POSSIBLE ADENYLATE CYCLASE (ATP FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)" FT /function="THOUGHT TO PLAY AN ESSENTIAL ROLES IN REGULATION FT OF CELLULAR METABOLISM BY CATALYSING THE SYNTHESIS OF A FT SECOND MESSENGER, cAMP. MAY BE INVOLVED IN VIRULENCE FT [CATALYTIC ACTIVITY: ATP = 3',5'-CYCLIC AMP + FT PYROPHOSPHATE]." FT /EC_number="4.6.1.1" FT /note="Rv1320c, (MTCY130.05c), len: 567 aa. Possible FT adenylate cyclase (EC 4.6.1.1) (see Rindi et al., 1999). FT Some similarity at the C-terminus to CYAA_RHIME|P19485 FT adenylate cyclase from Rhizobium meliloti (193 aa), FASTA FT scores: opt: 277, E(): 2e-12, (34.0% identity in 156 aa FT overlap); similar to other mycbacterium tuberculosis FT putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 FT aa), FASTA scores: opt: 2423, E(): 0, (68.7% identity in FT 534 aa overlap); Rv1319c|MTCY130.04c (535 aa), FASTA FT scores: opt: 2354, E(): 0, (66.3% identity in 534 aa FT overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL FT CYCLASE CLASS-3 FAMILY." FT /db_xref="GOA:Q10633" FT /db_xref="HSSP:1AWL" FT /db_xref="InterPro:IPR003660" FT /db_xref="UniProtKB/Swiss-Prot:Q10633" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98107.1" FT /translation="MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRM FT RRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI FT LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGL FT ANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTML FT VWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTAT FT PVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGR FT EVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNH FT HRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQV FT VAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGE FT TVTLRGHDQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD" FT CDS 101236..101916 FT /transl_table=11 FT /locus_tag="Rv1321" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1321, (MTCY130.06), len: 226 aa. Conserved FT hypothetical protein. Equivalent to P53524|YD21_MYCLE FT hypothetical protein from Mycobacterium leprae (201 aa), FT FASTA scores: opt: 1144, E(): 0, (87.6% identity in 193 aa FT overlap). Some similarity to hypothetical proteins from FT other organisms e.g. Y225_METJA|Q57678 Methanococcus FT jannaschii (263 aa), FASTA scores: E(): 6.5e-05, (25.0% FT identity in 212 aa overlap)." FT /db_xref="InterPro:IPR002793" FT /db_xref="UniProtKB/Swiss-Prot:Q10634" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98085.1" FT /translation="MSRVRLVIAQCTVDYIGRLTAHLPSARRLLLFKADGSVSVHADDR FT AYKPLNWMSPPCWLTEESGGQAPVWVVENKAGEQLRITIEGIEHDSSHELGVDPGLVKD FT GVEAHLQALLAEHIQLLGEGYTLVRREYMTAIGPVDLLCSDERGGSVAVEIKRRGEIDG FT VEQLTRYLELLNRDSVLAPVKGVFAAQQIKPQARILATDRGIRCLTLDYDTMRGMDSGE FT YRLF" FT CDS 101939..102235 FT /transl_table=11 FT /locus_tag="Rv1322" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1322, (MTCY130.07), len: 98 aa. Conserved FT hypothetical protein." FT /db_xref="UniProtKB/Swiss-Prot:P64805" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98086.1" FT /translation="MARRRKPLHRQRPEPPSWALRRVEAGPDGHEYEVRPVAAARAVKT FT YRCPGCDHEIRSGTAHVVVWPTDLPQAGVDDRRHWHTPCWANRATRGPTRKWT" FT CDS complement(102270..102728) FT /transl_table=11 FT /locus_tag="Rv1322A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1322A, len: 152 aa. Conserved hypothetical FT protein, similar to proteins from Mycobacterium leprae and FT Streptomyces coelicolor e.g. AL583921_2|ML1157 from M. FT leprae strain TN (155 aa), FASTA scores: opt: 771, E(): FT 5.1e-43, (75.3% identity in 154 aa overlap); and AL137242_2 FT from Streptomyces coelicolor (146 aa), FASTA scores: opt: FT 404, E(): 2e-19, (43.165% identity in 139 aa overlap)." FT /db_xref="GOA:Q8VK36" FT /db_xref="HSSP:1JC5" FT /db_xref="InterPro:IPR017515" FT /db_xref="UniProtKB/TrEMBL:Q8VK36" FT /protein_id="CAE55376.1" FT /translation="MMTTDQVHARHMLATSLVTGLDHVGIAVADLDVAIEWYHDHLGMI FT LVHEEINDDQGIREALLAVPGSAAQIQLMAPLDESSVIAKFLDKRGPGIQQLACRVSDL FT DAMCRRLRSQGVRLVYETARRGTANSRINFIHPKDAGGVLIELVEPAP" FT CDS 102819..103988 FT /transl_table=11 FT /gene="fadA4" FT /locus_tag="Rv1323" FT /product="PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA4 FT (ACETOACETYL-CoA THIOLASE)" FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID FT DEGRADATION [CATALYTIC ACTIVITY: 2 ACETYL-CoA = CoA + FT ACETOACETYL-COA]." FT /EC_number="2.3.1.9" FT /note="Rv1323, (MTCY130.08), len: 389 aa. Probable fadA4, FT acetyl-CoA acetyltransferase (EC 2.3.1.9), equivalent to FT THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase FT from Mycobacterium leprae (393 aa), FASTA scores: opt: FT 2218, E(): 0, (87.0% identity in 392 aa overlap). Also FT highly similar to others e.g. CAB70629.1|AL137242 probable FT acetoacetyl-CoA thiolase from Streptomyces coelicolor (401 FT aa); T51772 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) FT [validated] from Alcaligenes latus (392 aa); etc. Some FT homologies indicate ATA start codon. Contains PS00098 FT Thiolases acyl-enzyme intermediate signature, PS00737 FT Thiolases signature 2, and PS00099 Thiolases active site. FT BELONGS TO THE THIOLASE FAMILY." FT /db_xref="GOA:P66926" FT /db_xref="HSSP:1PXT" FT /db_xref="InterPro:IPR016038" FT /db_xref="UniProtKB/Swiss-Prot:P66926" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98087.1" FT /translation="MIVAGARTPIGKLMGSLKDFSASELGAIAIKGALEKANVPASLVE FT YVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGIDAIALADQLIRAREFD FT VVVAGGQESMTKAPHLLMNSRSGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQRNDV FT DMFTRSEQDEYAAASHQKAAAAWKDGVFADEVIPVNIPQRTGDPLQFTEDEGIRANTTA FT AALAGLKPAFRGDGTITAGSASQISDGAAAVVVMNQEKAQELGLTWLAEIGAHGVVAGP FT DSTLQSQPANAINKALDREGISVDQLDVVEINEAFAAVALASIRELGLNPQIVNVNGGA FT IAVGHPLGMSGTRITLHAALQLARRGSGVGVAALCGAGGQGDALILRAG" FT misc_feature 103056..103112 FT /note="PS00098 Thiolases acyl-enzyme intermediate FT signature" FT misc_feature 103821..103871 FT /note="PS00737 Thiolases signature 2" FT misc_feature 103926..103967 FT /note="PS00099 Thiolases active site" FT CDS 104118..105032 FT /transl_table=11 FT /locus_tag="Rv1324" FT /product="POSSIBLE THIOREDOXIN" FT /function="THIOREDOXIN PARTICIPATES IN VARIOUS REDOX FT REACTIONS THROUGH THE REVERSIBLE OXIDATION OF ITS ACTIVE FT CENTER DITHIOL, TO A DISULFIDE, & CATALYZES FT DITHIOL-DISULFIDE EXCHANGE REACTIONS" FT /EC_number="1.-.-.-" FT /note="Rv1324, (MTCY130.09), len: 304 aa. Possible FT thioredoxin (EC 1.-.-.-), similar to several e.g. FT U00014|Q49716 TRXA from Mycobacterium leprae (255 aa), FT FASTA scores: opt: 1014, E(): 0, (69.7% identity in 228 aa FT overlap); THIO_RHOSH|P08058 TrxA from Rhodobacter FT sphaeroides (105 aa), FASTA scores: opt 196, E(): 1.9e-06, FT (33.0% identity in 103 aa overlap). Contains PS00339 FT Aminoacyl-transfer RNA synthetases class-II signature 2." FT /db_xref="GOA:P64807" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/Swiss-Prot:P64807" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98088.1" FT /translation="MTRPRPPLGPAMAGAVDLSGIKQRAQQNAAASTDADRALSTPSGV FT TEITEANFEDEVIVRSDEVPVVVLLWSPRSEVCVDLLDTLSGLAAAAKGKWSLASVNVD FT VAPRVAQIFGVQAVPTVVALAAGQPISSFQGLQPADQLSRWVDSLLSATAGKLKGAASS FT EESTEVDPAVAQARQQLEDGDFVAARKSYQAILDANPGSVEAKAAIRQIEFLIRATAQR FT PDAVSVADSLSDDIDAAFAAADVQVLNQDVSAAFERLIALVRRTSGEERTRVRTRLIEL FT FELFDPADPEVVAGRRNLANALY" FT misc_feature 104874..104903 FT /note="PS00339 Aminoacyl-transfer RNA synthetases class-II FT signature 2" FT CDS complement(105111..106922) FT /transl_table=11 FT /gene="PE_PGRS24" FT /locus_tag="Rv1325c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1325c, (MTCY130.10c), len: 603 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT ala-, gly-rich proteins (see Brennan & Delogu 2002), FT similar to many e.g. YQ04_MYCTU|P71933 hypothetical 63.1 FT kDa glycine-rich protein (778 aa), FASTA scores: E(): 0, FT (52.3% identity in 724 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:Q10637" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55377.1" FT /translation="MSFVIAAPETLVRAASDLANIGSTLGAANAAALGPTTELLAAGAD FT EVSAAIASLFAAHGQAYQAVSAQMSAFHAQFVQTFTAGAGAYASAEAAAAAPLEGLLNI FT VNTPTQLLLGRPLIGNGANGAPGTGQAGGAGGLLYGNGGAGGSGAPGQAGGPGGAAGLF FT GNGGAGGAGGDGPGNGAAGGAGGAGGLLFGSGGAGGPGGVGNTGTGGLGGDGGAAGLFG FT AGGIGGAGGPGFNGGAGGAGGRSGLFEVLAAGGAGGTGGLSVNGGTGGTGGTGGGGGLF FT SNGGAGGAGGFGVSGSAGGNGGTGGDGGIFTGNGGTGGTGGTGTGNQLVGGEGGAGGAG FT GNAGILFGAGGIGGTGGTGLGAPDPGGTGGKGGVGGIGGAGALFGPGGAGGTGGFGASS FT ADQMAGGIGGSGGSGGAAKLIGDGGAGGTGGDSVRGAAGSGGTGGTGGLIGDGGAGGAG FT GTGIEFGSVGGAGGAGGNAAGLSGAGGAGGAGGFGETAGDGGAGGNAGLLNGDGGAGGA FT GGLGIAGDGGNGGKGGKAGMVGNGGDGGAGGASVVANGGVGGSGGNATLIGNGGNGGNG FT GVGSAPGKGGAGGTAGLLGLNGSPGLS" FT CDS complement(107074..109269) FT /transl_table=11 FT /gene="glgB" FT /locus_tag="Rv1326c" FT /product="PROBABLE 1,4-ALPHA-GLUCAN BRANCHING ENZYME GLGB FT (GLYCOGEN BRANCHING ENZYME)" FT /function="INVOLVED IN GLYCOGEN BIOSYNTHESIS (CYTOPLASMIC FT POLYSACCHARIDES) (THIRD STEP) [CATALYTIC ACTIVITY : FT FORMATION OF 1,6-GLUCOSIDIC LINKAGES OF GLYCOGEN]." FT /EC_number="2.4.1.18" FT /note="Rv1326c, (MTCY130.11c), len: 731 aa. Probable glgB, FT 1,4-alpha-glucan branching enzyme (EC 2.4.1.18), similar to FT others e.g. GLGB_ECOLI|P07762 Escherichia coli (728 aa), FT FASTA scores: opt: 2330, E(): 0, (48.7% identity in 719 aa FT overlap). Similar to other Mycobacterium tuberculosis FT putative alpha-glucan branching enzymes Rv1562c, Rv1563c. FT BELONGS TO FAMILY 13 OF GLYCOSYL HYDROLASES, ALSO KNOWN AS FT THE ALPHA-AMYLASE FAMILY." FT /db_xref="GOA:Q10625" FT /db_xref="HSSP:1M7X" FT /db_xref="InterPro:IPR013783" FT /db_xref="UniProtKB/Swiss-Prot:Q10625" FT /protein_id="CAA98090.1" FT /translation="MSRSEKLTGEHLAPEPAEMARLVAGTHHNPHGILGAHEYDDHTVI FT RAFRPHAVEVVALVGKDRFSLQHLDSGLFAVALPFVDLIDYRLQVTYEGCEPHTVADAY FT RFLPTLGEVDLHLFAEGRHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVSLIG FT EFNGWNGHEAPMRVLGPSGVWELFWPDFPCDGLYKFRVHGADGVVTDRADPFAFGTEVP FT PQTASRVTSSDYTWGDDDWMAGRALRNPVNEAMSTYEVHLGSWRPGLSYRQLARELTDY FT IVDQGFTHVELLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQAGIGVIV FT DWVPAHFPKDAWALGRFDGTPLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFLVANALYW FT LQEFHIDGLRVDAVASMLYLDYSRPEGGWTPNVHGGRENLEAVQFLQEMNATAHKVAPG FT IVTIAEESTPWSGVTRPTNIGGLGFSMKWNMGWMHDTLDYVSRDPVYRSYHHHEMTFSM FT LYAFSENYVLPLSHDEVVHGKGTLWGRMPGNNHVKAAGLRSLLAYQWAHPGKQLLFMGQ FT EFGQRAEWSEQRGLDWFQLDENGFSNGIQRLVRDINDIYRCHPALWSLDTTPEGYSWID FT ANDSANNVLSFMRYGSDGSVLACVFNFAGAEHRDYRLGLPRAGRWREVLNTDATIYHGS FT GIGNLGGVDATDDPWHGRPASAVLVLPPTSALWLTPA" FT CDS complement(109277..111382) FT /transl_table=11 FT /gene="glgE" FT /locus_tag="Rv1327c" FT /product="PROBABLE GLUCANASE GLGE" FT /function="UNKNOWN; PROBABLY INVOLVED IN POLYSACCHARIDES FT DEGRADATION." FT /note="Rv1327c, (MTCY130.12c), len: 701 aa. Probable glgE, FT glucanase, similar to AF172946|AF172946_2 putative FT glucanase GlgE from Mycobacterium smegmatis (697 aa), FASTA FT scores: opt: 3816, E(): 0, (78.5% identity in 692 aa FT overlap). Similar to putative alpha-amylases e.g. Q9L1K2 FT Streptomyces coelicolor (675 aa), FASTA scores: opt: 2243, FT E(): 7.4e-132, (54.2% identity in 684 aa overlap). Start FT changed since original submission (-36) based on similarity FT to GlgE of Mycobacterium smegmatis; previous start at FT position 1494531." FT /db_xref="GOA:P63531" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/Swiss-Prot:P63531" FT /protein_id="CAA98091.2" FT /translation="MSGRAIGTETEWWVPGRVEIDDVAPVVSCGVYPAKAVVGEVVPVS FT AAVWREGHEAVAATLVVRYLGVRYPHLTDRPRARVLPTPSEPQQRVKPLLIPMTSGQEP FT FVFHGQFTPDRVGLWTFRVDGWGDPIHTWRHGLIAKLDAGQGETELSNDLLVGAVLLER FT AATGVPRGLRDPLLAAAAALRTPGDPVTRTALALTPEIEELLADYPLRDLVTRGEQFGV FT WVDRPLARFGAWYEMFPRSTGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHP FT IGKVHRKGRNNSPTAAPTDVGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGME FT VALDLALQCAPDHPWAREHRQWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPEGLYDE FT VLRVVQHWVNHGVKFFRVDNPHTKPPNFWAWLIAQVKTVDPDVLFLSEAFTPPARQYGL FT AKLGFTQSYSYFTWRTTKWELTEFGNQIAELADYRRPNLFVNTPDILHAVLQHNGPGMF FT AIRAVLAATMSPAWGMYCGYELFEHRAVREGSEEYLDSEKYELRPRDFASALDQGRSLQ FT PFITRLNIIRRLHPAFQQLRTIHFHHVDNDALLAYSKFDPATGDCVLVVVTLNAFGPEE FT ATLWLDMAALGMEDYDRFWVRDEITGEEYQWGQANYIRIDPARAVAHIINMPAVPYESR FT NTLLRRR" FT CDS 111521..114112 FT /transl_table=11 FT /gene="glgP" FT /locus_tag="Rv1328" FT /product="PROBABLE GLYCOGEN PHOSPHORYLASE GLGP" FT /function="PHOSPHORYLASE IS AN IMPORTANT ALLOSTERIC ENZYME FT IN CARBOHYDRATE METABOLISM. ENZYMES FROM DIFFERENT SOURCES FT DIFFER IN THEIR REGULATORY MECHANISMS AND IN THEIR NATURAL FT SUBSTRATES. HOWEVER, ALL KNOWN PHOSPHORYLASES SHARE FT CATALYTIC AND STRUCTURAL PROPERTIES [CATALYTIC ACTIVITY : FT {(1,4)-ALPHA-D-GLUCOSYL}(N) + PHOSPHATE = FT {(1,4)-ALPHA-D-GLUCOSYL}(N-1) + ALPHA-D-GLUCOSE FT 1-PHOSPHATE]." FT /EC_number="2.4.1.1" FT /note="Rv1328, (MTCY130.13), len: 863 aa. Probable glgP, FT glycogen phosphorylase (EC 2.4.1.1), similar to many e.g. FT PHSG_HAEIN|P45180 glycogen phosphorylase from Haemophilus FT influenzae (821 aa), FASTA scores: E(): 6.9e-08, (25.6% FT identity in 675 aa overlap). BELONGS TO THE GLYCOGEN FT PHOSPHORYLASE FAMILY." FT /db_xref="GOA:Q10639" FT /db_xref="HSSP:1YGP" FT /db_xref="InterPro:IPR000811" FT /db_xref="UniProtKB/Swiss-Prot:Q10639" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98092.1" FT /translation="MKALRRFTVRAHLPERLAALDQLSTNLRWSWDKPTQDLFAAIDPA FT LWEQCGHDPVALLGAVNPARLDELALDAEFLGALDELAADLNDYLSRPLWYQEQQDAGV FT AAQALPTGIAYFSLEFGVAEVLPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRSGYF FT RQSLTADGWQHETYPSLDPQGLPLRLLTDANGDPVLVEVALGDNAVLRARIWVAQVGRV FT PLLLLDSDIPENEHDLRNVTDRLYGGDQEHRIKQEILAGIGGVRAIRAYTAVEKLTPPE FT VFHMNEGHAGFLGIERIRELVTDAGLDFDTALTVVRSSTVFTTHTPVPAGIDRFPLEMV FT QRYVNDQRGDGRSRLLPGLPADRIVALGAEDDPAKFNMAHMGLRLAQRANGVSLLHGRV FT SRAMFNELWAGFDPDEVPIGSVTNGVHAPTWAAPQWLQLGRELAGSDSLREPVVWQRLH FT QVDPAHLWWIRSQLRSMLVEDVRARLRQSWLERGATDAELGWIATAFDPNVLTVGFARR FT VPTYKRLTLMLRDPDRLEQLLLDEQRPIQLIVAGKSHPADDGGKALIQQVVRFADRPQV FT RHRIAFLPNYDMSMARLLYWGCDVWLNNPLRPLEACGTSGMKSALNGGLNLSIRDGWWD FT EWYDGENGWEIPSADGVADENRRDDLEAGALYDLLAQAVAPKFYERDERGVPQRWVEMV FT RHTLQTLGPKVLASRMVRDYVEHYYAPAAQSFRRTAGAQFDAARELADYRRRAEEAWPK FT IEIADVDSTGLPDTPLLGSQLTLTATVRLAGLRPNDVTVQGVLGRVDAGDVLMDPVTVE FT MAHTGTGDGGYEIFSTTTPLPLAGPVGYTVRVLPRHPMLAASNELGLVTLA" FT CDS complement(114152..116146) FT /transl_table=11 FT /gene="dinG" FT /locus_tag="Rv1329c" FT /product="PROBABLE ATP-DEPENDENT HELICASE DING" FT /function="PROBABLE HELICASE INVOLVED IN DNA REPAIR AND FT PERHAPS ALSO REPLICATION." FT /note="Rv1329c, (MTCY130.14c), len: 664 aa. Probable dinG, FT ATP-dependent helicase (see citation below), similar to FT several e.g. DING_HAEIN|P44680 probable ATP-dependent FT helicase ding from Haemophilus influenzae (640 aa), FASTA FT scores: opt: 685, E(): 2.3e-38, (32.8% identity in 644 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A." FT /db_xref="GOA:P64314" FT /db_xref="InterPro:IPR006555" FT /db_xref="UniProtKB/Swiss-Prot:P64314" FT /protein_id="CAA98093.1" FT /translation="MSESVSMSVPELLAIAVAALGGTRRRGQQEMAAAVAHAFETGEHL FT VVQAGTGTGKSLAYLVPAIIRALCDDAPVVVSTATIALQRQLVDRDLPQLVDSLTNALP FT RRPKFALLKGRRNYLCLNKIHNSVTASDHDDERPQEELFDPVAVTALGRDVQRLTAWAS FT TTVSGDRDDLKPGVGDRSWSQVSVSARECLGVARCPFGSECFSERARGAAGLADVVVTN FT HALLAIDAVAESAVLPEHRLLVVDEAHELADRVTSVAAAELTSATLGMAARRITRLVDP FT KVTQRLQAASATFSSAIHDARPGRIDCLDDEMATYLSALRDAASAARSAIDTGSDTTTA FT SVRAEAGAVLTEISDTASRILASFAPAIPDRSDVVWLEHEDNHESARAVLRVAPLSVAE FT LLATQVFARATTVLTSATLTIGGSFDAMATAWGLTADTPWRGLDVGSPFQHAKSGILYV FT AAHLPPPGRDGSGSAEQLTEIAELITAAGGRTLGLFSSMRAARAATEAMRERLSTPVLC FT QGDDSTSTLVEKFTADAATSLFGTLSLWQGVDVPGPSLSLVLIDRIPFPRPDDPLLSAR FT QRAVAARGGNGFMTVAASHAALLLAQGSGRLLRRVTDRGVVAVLDSRMATARYGEFLRA FT SLPPFWQTTNATQVRAALRRLARADAKAH" FT misc_feature complement(115979..116002) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(116170..117516) FT /transl_table=11 FT /locus_tag="Rv1330c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1330c, (MTCY130.15c), len: 448 aa. Conserved FT hypothetical protein, similar to others and also several FT nicotinate phosphoribosyltransferases e.g. O32090 YUEK FT PROTEIN from Bacillus subtilis (490 aa), FASTA scores: E(): FT 8.6e-22, (37.9% identity in 369 aa overlap). Also similar FT to Mycobacterium tuberculosis Rv0573c|MTV039.11c (38.0% FT identity in 437 aa overlap). Start changed since original FT submission based on similarity; previous start at position FT 1500740 (-61 aa)." FT /db_xref="GOA:Q10641" FT /db_xref="InterPro:IPR006405" FT /db_xref="UniProtKB/Swiss-Prot:Q10641" FT /protein_id="CAA98094.2" FT /translation="MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPT FT TFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFR FT GDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGR FT PLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHG FT GPTELAERAAFRAQVEALGPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVL FT ARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVY FT KLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTL FT PLVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA" FT CDS 117618..117923 FT /transl_table=11 FT /locus_tag="Rv1331" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1331, (MTCY130.16), len: 101 aa. Conserved FT hypothetical protein, highly similar to U00014|ML014 FT B1549_C2_207 from Mycobacterium leprae (94 aa), FASTA FT scores: opt: 573, E(): 2.9e-40, (90.3% identity in 93 aa FT overlap). Similar to AL096852|SCE19A_16 hypothetical FT protein from Streptomyces coelicolor (105 aa), FASTA FT scores: opt: 377, E(): 2.9e-22, (60.0% identity in 105 aa FT overlap)." FT /db_xref="GOA:P67647" FT /db_xref="HSSP:1MBX" FT /db_xref="InterPro:IPR014719" FT /db_xref="UniProtKB/Swiss-Prot:P67647" FT /protein_id="CAA98095.1" FT /translation="MAVVSAPAKPGTTWQRESAPVDVTDRAWVTIVWDDPVNLMSYVTY FT VFQKLFGYSEPHATKLMLQVHNEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR" FT CDS 117883..118539 FT /transl_table=11 FT /locus_tag="Rv1332" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv1332, (MTCY130.17), len: 218 aa. Possible FT regulatory protein, high similarity to ML014|U00014 M. FT leprae B1549_C3_236 (222 aa), FASTA scores: opt: 1158, E(): FT 0, (75.6% identity in 221 aa overlap). Helix turn helix FT motif fram aa 8-29 (+3.03 SD)." FT /db_xref="InterPro:IPR018561" FT /db_xref="UniProtKB/Swiss-Prot:P64809" FT /protein_id="CAA98096.1" FT /translation="MPPVCGRRCSRTGEIRGYSGSIVRRWKRVETRDGPRFRSSLAPHE FT AALLKNLAGAMIGLLDDRDSSSPSDELEEITGIKTGHAQRPGDPTLRRLLPDFYRPDDL FT DDDDPTAVDGSESFNAALRSLHEPEIIDAKRVAAQQLLDTVPDNGGRLELTESDANAWI FT AAVNDLRLALGVMLEIGPRGPERLPGNHPLAAHFNVYQWLTVLQEYLVLVLMGSR" FT CDS 118556..119590 FT /transl_table=11 FT /locus_tag="Rv1333" FT /product="PROBABLE HYDROLASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="3.-.-.-" FT /note="Rv1333, (MTCY130.18), len: 344 aa. Possible FT hydrolase (EC 3.-.-.-), similar to Q57326|D26094 endo-type FT 6-aminohexanoate oligomer hydrolase (355 aa), fasta scores: FT E(): 1.4e-10, (31.9% identity in 339 aa overlap). FT Equivalent to P53425|YD33_MYCLE HYPOTHETICAL 36.1 KD FT PROTEIN B154 Mycobacterium leprae (362 aa), FASTA scores: FT opt: 1735, E(): 0, (76.7% identity in 352 aa overlap)." FT /db_xref="GOA:P64811" FT /db_xref="InterPro:IPR005321" FT /db_xref="UniProtKB/Swiss-Prot:P64811" FT /protein_id="CAA98097.1" FT /translation="MNSITDVGGIRVGHYQRLDPDASLGAGWACGVTVVLPPPGTVGAV FT DCRGGAPGTRETDLLDPANSVRFVDALLLAGGSAYGLAAADGVMRWLEEHRRGVAMDSG FT VVPIVPGAVIFDLPVGGWNCRPTADFGYSACAAAGVDVAVGTVGVGVGARAGALKGGVG FT TASATLQSGVTVGVLAVVNAAGNVVDPATGLPWMADLVGEFALRAPPAEQIAALAQLSS FT PLGAFNTPFNTTIGVIACDAALSPAACRRIAIAAHDGLARTIRPAHTPLDGDTVFALAT FT GAVAVPPEAGVPAALSPETQLVTAVGAAAADCLARAVLAGVLNAQPVAGIPTYRDMFPG FT AFGS" FT CDS 119598..120038 FT /transl_table=11 FT /locus_tag="Rv1334" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1334, (MTCY130.19), len: 146 aa. Conserved FT hypothetical protein, similar to AL096852|SCE19A_13 FT hypothetical protein from Streptomyces coelicolor (140 aa), FT Fasta scores: opt: 579, E(): 0, (65.0% identity in 140 aa FT overlap); and Q54330|M29166 MEC+ from Streptomyces FT kasugaensis (115 aa), FASTA scores; E(): 7.6e-33, (56.9% FT identity in 109 aa overlap)." FT /db_xref="InterPro:IPR000555" FT /db_xref="UniProtKB/Swiss-Prot:P64813" FT /protein_id="CAA98098.1" FT /translation="MLLRKGTVYVLVIRADLVNAMVAHARRDHPDEACGVLAGPEGSDR FT PERHIPMTNAERSPTFYRLDSGEQLKVWRAMEDADEVPVVIYHSHTATEAYPSRTDVKL FT ATEPDAHYVLVSTRDPHRHELRSYRIVDGAVTEEPVNVVEQY" FT CDS 120060..120341 FT /transl_table=11 FT /locus_tag="Rv1335" FT /product="9.5 KDA CULTURE FILTRATE ANTIGEN CFP10A" FT /function="UNKNOWN" FT /note="Rv1335, (MT1376.1, MTCY130.20), len: 93 aa. 9.5 kDa FT culture filtrate antigen cfp10A (see citation below). FT Similar to hypothetical proteins from other organisms e.g. FT P74060|D90911 Synechocystis (109 aa), FASTA scores: E(): FT 2.3e-20, (49.5% identity in 93 aa overlap)." FT /db_xref="GOA:P0A646" FT /db_xref="InterPro:IPR003749" FT /db_xref="PDB:3DWG" FT /db_xref="UniProtKB/Swiss-Prot:P0A646" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98099.1" FT /translation="MNVTVSIPTILRPHTGGQKSVSASGDTLGAVISDLEANYSGISER FT LMDPSSPGKLHRFVNIYVNDEDVRFSGGLATAIADGDSVTILPAVAGG" FT CDS 120351..121322 FT /transl_table=11 FT /gene="cysM" FT /locus_tag="Rv1336" FT /product="PROBABLE CYSTEINE SYNTHASE B CYSM (CSASE B) FT (O-acetylserine sulfhydrylase B) (O-acetylserine FT (Thiol)-lyase B)" FT /function="INVOLVED IN CYSTEINE BIOSYNTHESIS [CATALYTIC FT ACTIVITY : O3-ACETYL-L-SERINE + H(2)S = L-CYSTEINE + FT ACETATE]" FT /EC_number="2.5.1.47" FT /note="Rv1336, (MTCY130.21), len: 323 aa. Probable cysM, FT cysteine synthase B (EC 4.2.99.8), similar to many e.g. FT CYSM_ECOLI|P16703 Escherichia coli (303 aa), FASTA scores: FT opt: 720, E(): 4.6e-40, (41.1% identity in 302 aa overlap). FT Also similar to other Mycobacterium tuberculosis cysteine FT synthase subunits e.g. Rv1077, Rv2334, Rv0848, etc. FT Contains PS00901 Cysteine synthase/cystathionine FT beta-synthase P-phosphate attachment site. BELONGS TO THE FT CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY." FT /db_xref="GOA:P63873" FT /db_xref="InterPro:IPR001926" FT /db_xref="PDB:3DKI" FT /db_xref="UniProtKB/Swiss-Prot:P63873" FT /protein_id="CAA98100.1" FT /translation="MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRN FT PTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPEN FT TSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYC FT GTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNM FT DEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGAL FT AAGERADIALVVADAGWKYLSTGAYAGSLDDAETALEGQLWA" FT misc_feature 120468..120524 FT /note="PS00901 Cysteine synthase/cystathionine FT beta-synthase P-phosphate attachment site" FT CDS 121313..122035 FT /transl_table=11 FT /locus_tag="Rv1337" FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1337, (MTCY130.22), len: 240 aa. Probable integral FT membrane protein. Highly similar to P53426 hypothetical FT protein B1549_C3_240 from M.leprae (251); and P74553|D90916 FT hypothetical protein from Synechocystis sp. (198 aa), FASTA FT scores: E(): 2.3e-25, (43.6% identity in 181 aa overlap)." FT /db_xref="GOA:P64815" FT /db_xref="InterPro:IPR002610" FT /db_xref="UniProtKB/Swiss-Prot:P64815" FT /protein_id="CAA98101.1" FT /translation="MGMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILT FT FVALLYLVELIDQLSGSRLDVNGIRPLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLG FT FLMTLAGLSRFVWATAIIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLLVFG FT LFVRKGWDIVIGLVVLFVYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPE FT RKARALKRAGARSGHPKL" FT CDS 122032..122847 FT /transl_table=11 FT /gene="murI" FT /locus_tag="Rv1338" FT /product="PROBABLE GLUTAMATE RACEMASE MURI" FT /function="INVOLVED IN PEPTIDOGLYCAN BIOSYNTHESIS. PROVIDES FT THE (R)-GLUTAMIC ACID REQUIRED FOR CELL WALL BIOSYNTHESIS FT [CATALYTIC ACTIVITY : L-GLUTAMATE = D-GLUTAMATE]" FT /EC_number="5.1.1.3" FT /note="Rv1338, (MTCY130.23), len: 271 aa. Probable murI, FT glutamate racemase (EC 5.1.1.3), highly similar to many FT e.g. MURI_MYCLE|P46705 (272 aa), FASTA scores: opt: 1559, FT E(): 0, (88.9% identity in 271 aa overlap). Contains FT PS00924 Aspartate and glutamate racemases signature 2." FT /db_xref="GOA:P63635" FT /db_xref="HSSP:1B74" FT /db_xref="InterPro:IPR018187" FT /db_xref="UniProtKB/Swiss-Prot:P63635" FT /protein_id="CAA98102.1" FT /translation="MNSPLAPVGVFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYG FT PLTIPEIRAHALAIGDDLVGRGVKALVIACNSASSACLRDARERYQVPVVEVILPAVRR FT AVAATRNGRIGVIGTRATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGRQVL FT GLAQGYLEPLQRAEVDTLVLGCTHYPLLSGLIQLAMGENVTLVSSAEETAKEVVRVLTE FT IDLLRPHDAPPATRIFEATGDPEAFTKLAARFLGPVLGGVQPVHPSRIH" FT misc_feature 122572..122604 FT /note="PS00924 Aspartate and glutamate racemases signature FT 2" FT CDS 122874..123695 FT /transl_table=11 FT /locus_tag="Rv1339" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1339, (MTCY130.24), len: 273 aa. Conserved FT hypothetical protein, highly similar to Y211_MYCLE|P50474 FT hypothetical protein b1549_c2_211 from Mycobacterium leprae FT (284 aa), FASTA scores: opt: 1672, E(): 0, (86.2% identity FT in 276 aa overlap). Also similar to AL096852|SCE19A.08 FT hypothetical protein from Streptomyces coelicolor (250 aa), FT FASTA scores: opt: 630, E(): 0, (42.2% identity in 256 aa FT overlap). Similar to M. tuberculosis hypothetical proteins FT Rv3796, Rv2407." FT /db_xref="UniProtKB/Swiss-Prot:P66873" FT /protein_id="CAA99972.1" FT /translation="MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAPH FT TPPLVIDFGGGVLGALQRHADPASVHVLLSHLHADHCLDLPGLFVWRRYHPSRPSGKAL FT LYGPSDTWSRLGAASSPYGGEIDDCSDIFDVHHWADSEPVTLGALTIVPRLVAHPTESF FT GLRITDPSGASLAYSGDTGICDQLVELARGVDVFLCEASWTHSPKHPPDLHLSGTEAGM FT VAAQAGVRELLLTHIPPWTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG" FT CDS 123712..124491 FT /transl_table=11 FT /gene="rphA" FT /locus_tag="Rv1340" FT /product="PROBABLE RIBONUCLEASE RPHA (RNase PH) (tRNA FT nucleotidyltransferase)" FT /function="RNase PH IS A PHOSPHOROLYTIC EXORIBONUCLEASE FT THAT REMOVES NUCLEOTIDE RESIDUES FOLLOWING THE -CCA FT TERMINUS OF tRNA AND ADDS NUCLEOTIDES TO THE ENDS OF RNA FT MOLECULES BY USING NUCLEOSIDE DIPHOSPHATES AS SUBSTRATES FT [CATALYTIC ACTIVITY: {TRNA}(N+1) + PHOSPHATE = {TRNA}(N) + FT A NUCLEOSIDE DIPHOSPHATE]." FT /EC_number="2.7.7.56" FT /note="Rv1340, (MTCY130.25), len: 259 aa. Probable rphA, FT Ribonuclease ph (EC 2.7.7.56), highly similar to others FT e.g. RNPH_MYCLE|P37939 Mycobacterium leprae (259 aa), FASTA FT scores: opt: 1524, E(): 0, (88.8% identity in 259 aa FT overlap). BELONGS TO THE RNASE PH FAMILY." FT /db_xref="GOA:Q10628" FT /db_xref="InterPro:IPR002381" FT /db_xref="PDB:3B4T" FT /db_xref="UniProtKB/Swiss-Prot:Q10628" FT /protein_id="CAA99973.1" FT /translation="MSKREDGRLDHELRPVIITRGFTENPAGSVLIEFGHTKVLCTASV FT TEGVPRWRKATGLGWLTAEYAMLPSATHSRSDRESVRGRLSGRTQEISRLIGRSLRACI FT DLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLSAAGKLSDPRPLSCAIA FT AVSVGVVDGRIRVDLPYEEDSRAEVDMNVVATDTGTLVEIQGTGEGATFARSTLDKLLD FT MALGACDTLFAAQRDALALPYPGVLPQGPPPPKAFGT" FT repeat_region 124488..124538 FT /note="51 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 124530..125144 FT /transl_table=11 FT /locus_tag="Rv1341" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1341, (MTCY130.26), len: 204 aa. Conserved FT hypothetical protein, some similarity to P52061|YGGV_ECOLI FT HYPOTHETICAL PROTEIN yggV (197 aa), FASTA scores: opt: 521, FT E(): 7.9e-27, (46.0% identity in 200 aa overlap). FT Equivalent to ML014|U00014 hypothetical protein FT B1549_C2_213 from Mycobacterium leprae (285 aa), FASTA FT scores: opt: 1073, E(): 0, (83.0% identity in 206 aa FT overlap)." FT /db_xref="GOA:P64307" FT /db_xref="InterPro:IPR002637" FT /db_xref="UniProtKB/Swiss-Prot:P64307" FT /protein_id="CAA99974.1" FT /translation="MALVTKLLVASRNRKKLAELRRVLDGAGLSGLTLLSLGDVSPLPE FT TPETGVTFEDNALAKARDAFSATGLASVADDSGLEVAALGGMPGVLSARWSGRYGDDAA FT NTALLLAQLCDVPDERRGAAFVSACALVSGSGEVVVRGEWPGTIAREPRGDGGFGYDPV FT FVPYGDDRTAAQLSPAEKDAVSHRGRALALLLPALRSLATG" FT CDS complement(125141..125503) FT /transl_table=11 FT /locus_tag="Rv1342c" FT /product="CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1342c, (MTCY02B10.06c), len: 120 aa. Conserved FT membrane protein. Highly similar to G466926|P54133 FT hypothetical protein B1549_F2_59 from Mycobacterium leprae FT (119 aa), FASTA scores, opt: 544, E(): 1.9e-29, (68.3 % FT identity in 120 aa overlap)." FT /db_xref="GOA:P0A5E7" FT /db_xref="UniProtKB/Swiss-Prot:P0A5E7" FT /protein_id="CAE55378.1" FT /translation="MTAPETPAAQHAEPAIAVERIRTALLGYRIMAWTTGLWLIALCYE FT IVVRYVVKVDNPPTWIGVVHGWVYFTYLLLTLNLAVKVRWPLGKTAGVLLAGTIPLLGI FT VVEHFQTKEIKARFGL" FT CDS complement(125500..125880) FT /transl_table=11 FT /gene="lprD" FT /locus_tag="Rv1343c" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRD" FT /function="UNKNOWN" FT /note="Rv1343c, (MTCY02B10.07c), len: 126 aa. Probable FT lprD, conserved lipoprotein, highly similar to G466928 FT Mycobacterium leprae protein B1549_F3_106 (126 aa), FASTA FT scores, opt: 704, E(): 7.5e-36, (78.4 % identity in 125 aa FT overlap). Has N-terminal signal sequence and appropriately FT positioned prokaryotic lipoprotein attachment site. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:Q11013" FT /db_xref="UniProtKB/Swiss-Prot:Q11013" FT /protein_id="CAA99976.1" FT /translation="MSTTRRRRPALIALVIIATCGCLALGWWQWTRFQSTSGTFQNLGY FT ALQWPLFAWFCVYAYRNFVRYEETPPQPPTGGAAAEIPAGLLPERPKPAQQPPDDPVLR FT EYNAYLAELAKDDARKQNRTTA" FT CDS 125925..126245 FT /transl_table=11 FT /locus_tag="Rv1344" FT /product="PROBABLE ACYL CARRIER PROTEIN (ACP)" FT /function="THOUGHT TO BE INVOLVED IN DE NOVO FATTY ACID FT BIOSYNTHESIS; THIS PROTEIN IS THE CARRIER OF THE GROWING FT FATTY ACID CHAIN IN FATTY ACID BIOSYNTHESIS" FT /note="Rv1344, (MTCY02B10.08), len: 106 aa. Possible acyl FT carrier protein, similar to others e.g. ACP_RHIME|P19372 FT Rhizobium meliloti (77 aa), FASTA scores: opt: 117, E(): FT 0.03, (29.9% identity in 67 aa overlap) and FT ACP_SYNY3|P20804 acyl carrier protein (acp) from FT Synechocystis sp (77 aa), FASTA scores: E(): 7.1e-05, FT (34.8% identity in 66 aa overlap). Also similar to Rv2244 FT and Rv0033 from Mycobacterium tuberculosis." FT /db_xref="GOA:P63452" FT /db_xref="InterPro:IPR006162" FT /db_xref="UniProtKB/Swiss-Prot:P63452" FT /protein_id="CAA99977.1" FT /translation="MWRYPLSTRLALPNTPGVASFAMTSSPSTVSTTLLSILRDDLNID FT LTRVTPDARLVDDVGLDSVAFAVGMVAIEERLGVALSEEELLTCDTVGELEAAIAAKYR FT DE" FT CDS 126238..127803 FT /transl_table=11 FT /gene="fadD33" FT /locus_tag="Rv1345" FT /product="POSSIBLE POLYKETIDE SYNTHASE FADD33" FT /function="UNKNOWN, BUT POSSIBLY INVOLVED IN LIPID FT DEGRADATION." FT /note="Rv1345, (MTCY02B10.09), len: 521 aa. Possible FT fadD33, polyketide synthase, similar to N-terminus of FT T34918 polyketide synthase from Streptomyces coelicolor FT (2297 aa); and PKSJ_BACSU|P40806 putative polyketide FT biosynthesis protein from Bacillus subtilis (557 aa), FASTA FT scores: opt: 537, E(): 8.2e-27, (27.1% identity in 468 aa FT overlap). Also similar to other proteins from Mycobacterium FT tuberculosis eg Rv1013|MTCI237.30|MTCY10G2.36c|pks16 FT PUTATIVE POLYKETIDE SYNTHASE (544 aa); etc." FT /db_xref="GOA:P0A4X8" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/Swiss-Prot:P0A4X8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA99978.1" FT /translation="MSELAAVLTRSMQASAGDLMVLDRETSLWCRHPWPEVHGLAESVA FT AWLLDHDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGANDQRWADATLTRF FT LGIGVRTVLSQGSYLARLRSVDTAGVTIGDLSTAAHTNRSATPVASEGPAVLQGTAGST FT GAPRTAILSPGAVLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLAFVLSAALAGAPLW FT LAPTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARRVSEVDLGALRVTLNGGE FT PVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPGIGLLADRVIDGSGAHK FT HAVLGNPIPGMEVRISCGDQAAGNASREIGEIEIRGASMMAGYLGQQPIDPDDWFATGD FT LGYLGAGGLVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDRSTRPG FT LVVAAEFRGPDEANARAELIQRVASECGIVPSDVVFVSPGSLPRTSSGKLRRLAVRRSL FT EMAD" FT CDS 127803..128963 FT /transl_table=11 FT /gene="fadE14" FT /locus_tag="Rv1346" FT /product="POSSIBLE ACYL-CoA DEHYDROGENASE FADE14" FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv1346, (MTCY02B10.10), len: 386 aa. Possible FT fadE14, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. NP_251579.1|NC_002516 probable acyl-CoA FT dehydrogenase from Pseudomonas aeruginosa (386 aa); FT NP_036951.1|NM_012819|ACDL_RAT|P15650 acyl Coenzyme A FT dehydrogenase (long chain) from Rattus norvegicus (430 aa), FT FASTA scores: opt: 414, E(): 1.2e-18, (26.1% identity in FT 376 aa overlap); etc." FT /db_xref="GOA:P63431" FT /db_xref="InterPro:IPR013764" FT /db_xref="UniProtKB/Swiss-Prot:P63431" FT /protein_id="CAA99979.1" FT /translation="MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLGV FT CGVFDAKWATDARPDVGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYLRD FT ICDQAIRGAAVLCIGASEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMV FT VARSVDHDPTSRHGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCIDTWVPADALVAR FT AGTGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQALRLRMA FT DLQARVDLLRYALHGIAEQGRLELRTAAAVKVTAARLGEEVISECMHIFGGAGYLVDET FT TLGKWWRDMKLARVGGGTDEVLWELVAAGMTPDHDGYAAVVGASKA" FT CDS complement(128930..129562) FT /transl_table=11 FT /locus_tag="Rv1347c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1347c, (MTCY02B10.11c), len: 210 aa. Conserved FT hypothetical protein, some similarity to the C-terminus of FT malonyl-coenzyme A carboxylases e.g. G545170 FT malonyl-coenzyme A carboxylase (417 aa), FASTA scores: opt: FT 392, E(): 4.9 e-20, (35.6% identity in 174 aa overlap)." FT /db_xref="GOA:P64819" FT /db_xref="InterPro:IPR019432" FT /db_xref="PDB:1YK3" FT /db_xref="UniProtKB/Swiss-Prot:P64819" FT /protein_id="CAA99980.1" FT /translation="MTKPTSAGQADDALVRLARERFDLPDQVRRLARPPVPSLEPPYGL FT RVAQLTDAEMLAEWMNRPHLAAAWEYDWPASRWRQHLNAQLEGTYSLPLIGSWHGTDGG FT YLELYWAAKDLISHYYDADPYDLGLHAAIADLSKVNRGFGPLLLPRIVASVFANEPRCR FT RIMFDPDHRNTATRRLCEWAGCKFLGEHDTTNRRMALYALEAPTTAA" FT tRNA 129685..129768 FT /gene="tRNA-Leu(TAG)" FT /product="transfer RNA-Leu(TAG)" FT /anticodon=(pos:129719..129721,aa:Leu) FT CDS 130004..132583 FT /transl_table=11 FT /locus_tag="Rv1348" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1348, (MTCY02B10.12), len: 859 aa. Probable FT drugs-transport transmembrane protein ATP binding protein FT ABC transporter (see citation below), similar to FT HMT1_SCHPO|Q02592 heavy metal tolerance protein precursor FT from Schizosaccharomyces pombe (830 aa), FASTA scores: opt: FT 806, E(): 5.1e-39, (32.9% identity in 504 aa overlap); etc. FT Also similar to MTCY02B10.13 from Mycobacterium FT tuberculosis, FASTA score: (31.9% identity in 576 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00211 ABC transporters family signature. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS)." FT /db_xref="GOA:P63391" FT /db_xref="HSSP:1JJ7" FT /db_xref="InterPro:IPR007037" FT /db_xref="UniProtKB/Swiss-Prot:P63391" FT /protein_id="CAA99981.1" FT /translation="MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQD FT AEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTV FT KPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQH FT DDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLR FT DEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQA FT ASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVGFAAVGL FT LGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTL FT ALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPR FT IVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTL FT MDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTG FT LLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRP FT GTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQ FT LVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVLGANSGLSGGERQR FT LTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQ FT IVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQDGTR" FT misc_feature 131930..131953 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 132239..132283 FT /note="PS00211 ABC transporters family signature" FT CDS 132580..134319 FT /transl_table=11 FT /locus_tag="Rv1349" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1349, (MTCY02B10.13), len: 579 aa. Probable FT drugs-transport transmembrane ATP binding protein ABC FT transporter (see citation below), most similar to FT YWJA_BACSU|P45861 hypothetical ABC transporter from FT Bacillus subtilis (575 aa), FASTA scores: opt: 721, E(): FT 1.8e-35, (28.9% identity in 567 aa overlap); etc. Also FT similar to MTCY02B10.12 from Mycobacterium tuberculosis, FT FASTA score: (31.9% identity in 576 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 FT ABC transporters family signature. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:P63393" FT /db_xref="HSSP:1MT0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P63393" FT /protein_id="CAA99982.1" FT /translation="MIRTWIALVPNDHRARLIGFALLAFCSVVARAVGTVLLVPLMAAL FT FGEAPQRAWLWLGWLSAATVAGWVLDAVTARIGIELGFAVLNHTQHDVADRLPVVRLDW FT FTAENTATARQAIAATGPELVGLVVNLVTPLTSAILLPAVIALALLPISWQLGVAALAG FT VPLLLGALWASAAFARRADTAADKANTALTERIIEFARTQQALRAARRVEPARSLVGNA FT LASQHTATMRLLGMQIPGQLLFSIASQLALIVLAGTTAALTITGTLTVPEAIALIVVMV FT RYLEPFTAVSELAPALESTRATLGRIGSVLTAPVMVAGSGTWRDGAVVPRIEFDDVAFG FT YDGGSGPVLDGVSFCLQPGTTTAIVGPSGCGKSTILALIAGLHQPTRGRVLIDGTDVAT FT LDARAQQAVCSVVFQHPYLFHGTIRDNVFAADPGASDDQFAQAVRLARVDELIARLPDG FT ANTIVGEAGSALSGGERQRVSIARALLKAAPVLLVDEATSALDAENEAAVVDALAADPR FT SRTRVIVAHRLASIRHADRVLFVDDGRVVEDGSISELLTAGGRFSQFWRQQHEAAEWQI FT LAE" FT misc_feature 133675..133698 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 133987..134031 FT /note="PS00211 ABC transporters family signature" FT CDS 134448..135191 FT /transl_table=11 FT /gene="fabG2" FT /locus_tag="Rv1350" FT /product="PROBABLE 3-OXOACYL-[ACYL-CARRIER PROTEIN] FT REDUCTASE FABG2 (3-KETOACYL-ACYL CARRIER PROTEIN FT REDUCTASE)" FT /function="INVOLVED IN THE FATTY ACID BIOSYNTHESIS PATHWAY FT (FIRST REDUCTION STEP) [CATALYTIC ACTIVITY: FT (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = FT 3-oxoacyl-[acyl-carrier protein] + NADPH]." FT /EC_number="1.1.1.100" FT /note="Rv1350, (MTCY02B10.14), len: 247 aa. Probable fabG2, FT 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100), FT highly similar to many e.g. NP_350157.1|NC_003030 FT 3-ketoacyl-acyl carrier protein reductase from Clostridium FT acetobutylicum (249 aa); NP_229523.1|NC_000853 FT 3-oxoacyl-(acyl carrier protein) reductase from Thermotoga FT maritima (246 aa); AAC44307.1|U59433 3-ketoacyl-acyl FT carrier protein reductase from Bacillus subtilis (246 aa); FT etc. Contains PS00061 Short-chain dehydrogenases/reductases FT family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P66781" FT /db_xref="HSSP:1FK8" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P66781" FT /protein_id="CAA99983.1" FT /translation="MASLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEATE FT VAAKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTMTE FT EQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKAGIV FT GMTKAAAKELAHLGIRVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASV FT AVFLASDLSSYMTGTVLDVTGGRFI" FT misc_feature 134871..134957 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 135188..135517 FT /transl_table=11 FT /locus_tag="Rv1351" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1351, (MTCY02B10.15), len: 109 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64821" FT /protein_id="CAA99984.1" FT /translation="MTPRSLPRYGNSSRRKSFPMHRPSNVATATRKKSSIGWVLLACSV FT AGCKGIDTTEFILGRAGAFELAVRAAQHRHRYLTMVNVGRAPPRRCRTVCMAATDTPRN FT IRLNG" FT CDS 135720..136091 FT /transl_table=11 FT /locus_tag="Rv1352" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1352, (MTCY02B10.16), len: 123 aa. Conserved FT hypothetical protein, some similarity to Rv1906c|MTCY180.12 FT hypothetical protein from Mycobacterium tuberculosis (156 FT aa), FASTA scores: E(): 4e-05, (36.2% identity in 116 aa FT overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64823" FT /protein_id="CAA99985.1" FT /translation="MARTLALRASAGLVAGMAMAAITLAPGARAETGEQFPGDGVFLVG FT TDIAPGTYRTEGPSNPLILVFGRVSELSTCSWSTHSAPEVSNENIVDTNTSMGPMSVVI FT PPTVAAFQTHNCKLWMRIS" FT CDS complement(136157..136942) FT /transl_table=11 FT /locus_tag="Rv1353c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1353c, (MTCY02B10.17c), len: 261 aa. Probable FT transcriptional regulatory protein, similar to FT TER1_ECOLI|P03038 tetracycline repressor protein class A FT from Escherichia coli (216 aa), FASTA scores, opt: 231, FT E(): 1.6e-08, (31.3% identity in 211 aa overlap). Helix FT turn helix motif present at aa 3859 (+3.59 SD). BELONGS TO FT THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:P67434" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:P67434" FT /protein_id="CAA99986.1" FT /translation="MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKH FT LGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFAD FT NPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVV FT LDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILD FT HAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR" FT CDS complement(136962..138833) FT /transl_table=11 FT /locus_tag="Rv1354c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1354c, (MTCY02B10.18c), len: 623 aa. Conserved FT hypothetical protein, similar to many hypothetical proteins FT e.g. the C-terminus of G1001455 Synechocystis sp. (1244 FT aa), FASTA scores: opt: 933, E(): 0, (36.8% identity in 462 FT aa overlap); also similar to Rv1357c|MTCY02B10.21c (34.0% FT identity in 253 aa overlap)." FT /db_xref="InterPro:IPR003018" FT /db_xref="UniProtKB/Swiss-Prot:P64825" FT /protein_id="CAA99987.1" FT /translation="MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG FT VDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLVFR FT PEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTI FT ATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLDLD FT RLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPL FT AERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSV FT AIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTR FT GLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTG FT GFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGY FT SAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAA FT RILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS" FT CDS complement(138842..140989) FT /transl_table=11 FT /gene="moeY" FT /locus_tag="Rv1355c" FT /product="POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY" FT /function="INVOLVED IN BIOSYNTHESIS OF A DEMOLYBDO COFACTOR FT (MOLYBDOPTERIN), NECESSARY FOR MOLYBDOENZYMES. PLAYS A ROLE FT IN THE ACTIVATION OF THE SMALL SUBUNIT OF THE MOLYBDOPTERIN FT CONVERTING FACTOR (MOAD)" FT /note="Rv1355c, (MTCY02B10.19c), len: 715 aa. Possible FT moeY, Molybdopterin biosynthesis protein, very weak FT similarity to MOEB_ECOLI|P12282 molybdopterin biosynthesis FT moeb protein (249 aa), FASTA scores, opt: 180, E(): FT 8.5e-05, (29.3% identity in 174 aa overlap)." FT /db_xref="GOA:Q11025" FT /db_xref="InterPro:IPR000594" FT /db_xref="UniProtKB/Swiss-Prot:Q11025" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA99988.1" FT /translation="MTIPHEGGSTGILVLRDDDHDDVLVLDRLRSDPSIEFVDRFAEQL FT AGVRRLLPQPDPDLLEEAKRWAYYPWRRMVVAILGLRGFRAVRLDRNRHLITAEEQRAL FT HALRVGVVGLSAGHAIAYTLAAEGACGTLRLADFDKIELSNLNRVPVGVFDIGLNKAMI FT AARRIAELDPYLAVDLVTSGLSPESVDEFLDGLDVVIEECDSLDIKVILRQAACARGVP FT VLMATSDRGLVDVERYDVEPGRPIFHGLLGDIDADKLCGLTTKDKVPHVLNILDCQELS FT ARCAASMIEVDQTLWGWPQLAGDIWVGAATVAEAVRRIGLGEPLESGRVRVDVSAALDR FT LDQPPMPSRGNGWLLESVPPTAPAEPQPTSEIVAQAAIRAPSGGNVQPWHVVAKQHSLT FT IRLAPEHTSAMDIAFRGSAVAVGAAMFNARVAAAAHRVLGSVEFDESQPDSPLQATMHF FT GRGDDPSLAALYRPMLLRTTNRHHGMPGHVHPATVELLTNTAAAEGARLQLLLSRNEID FT RAATILAAADRIRYLTPRLHEEMMSELRWPGDPSLDAGIDVRSLELDSGELRVLDILRR FT SDVVARLAQWDCGTALEDNTNERVSASSALAIVYVDGATLTDFARGGSAMQAVWIVAQQ FT HGLAVQPMSPIFLYARGRHDLDQASPHFAAQLHRLQLDFRELVKPGKEGHEVLIFRLFH FT APPPSVCSRRRVRHAIPEPHR" FT CDS complement(140986..141777) FT /transl_table=11 FT /locus_tag="Rv1356c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1356c, (MTCY02B10.20c), len: 263 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64827" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA99989.1" FT /translation="MLIAGYLTDWRIMTTAQLRPIAPQKLHFSENLSVWVSDAQCRLVV FT SQPALDPTLWNTYLQGALRAYSKHGVECTLDLDAISDGSDTQLFFAAIDIGGDVVGGAR FT VIGPLRSADDSHAVVEWAGNPGLSAVRKMINDRAPFGVVEVKSGWVNSDAQRSDAIAAA FT LARALPLSMSLLGVQFVMGTAAAHALDRWRSSGGVIAARIPAAAYPDERYRTKMIWWDR FT RTLANHAEPKQLSRMLVESRKLLRDVEALSATTAATAGAEQ" FT CDS complement(142250..143173) FT /transl_table=11 FT /locus_tag="Rv1357c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1357c, (MTCY02B10.21c), len: 307 aa. Conserved FT hypothetical protein, similar to members of the FT YEGE/YHJK/YJCC family e.g. Y4LL_RHISN|P55552 hypothetical FT protein Y4ll from Rhizobium sp. (827 aa), FASTA scores: FT E(): 0, (37.7% identity in 257 aa overlap), also similar to FT Rv1354c|MTCY02B10.18c (34.0% identity in 253 aa overlap). FT BELONGS TO THE YEGE/YHDA/YHJK/YJCC FAMILY." FT /db_xref="GOA:P64829" FT /db_xref="InterPro:IPR001633" FT /db_xref="UniProtKB/Swiss-Prot:P64829" FT /protein_id="CAA99962.1" FT /translation="MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWAD FT SDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLP FT GRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVL FT VEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAY FT LPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAA FT RLRAFGCKAAQGWHFAKALPVDFFRE" FT CDS 143569..147048 FT /transl_table=11 FT /locus_tag="Rv1358" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1358, (MTCY02B10.22), len: 1159 aa. Probable FT transcriptional regulatory protein, some similarity to FT AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces FT coelicolor (993 aa), FASTA scores: opt: 210, E(): 5.5e-06, FT (27.5% identity in 739 aa overlap). Similar also to FT Rv0890C|MTCY31.18c (65.5% identity in 884 aa overlap) and FT to Rv1359|MTCY02B10.23 (43.7% identity in 197 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A, PS00622 FT Bacterial regulatory proteins, luxR family signature. Helix FT turn helix motif present at aa 1116-1137, (Score 1291, FT +3.59 SD)." FT /db_xref="GOA:Q11028" FT /db_xref="HSSP:1FSE" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:Q11028" FT /protein_id="CAA99963.1" FT /translation="MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQ FT IARTGHMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLNEL FT AADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLAPMR FT PRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPANTWLT FT DVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEVQ FT EVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALG FT LIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRES FT IGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIVADNFDAVSEICRRLDGMPLAI FT ELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWSYALLTDTERILF FT RRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLL FT ETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRA FT AFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARAL FT AEKVILKAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQ FT PYFAEAIELARAINDEWTLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVS FT RQCRLFACLAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIGDSAA FT RTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAIEASEASWDLRNQHNVVTAHH FT ELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELGKARDDAHAA FT VACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGY FT EAATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKI FT VKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST" FT misc_feature 144448..144471 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 146908..146991 FT /note="PS00622 Bacterial regulatory proteins, luxR family FT signature" FT CDS 147130..147882 FT /transl_table=11 FT /locus_tag="Rv1359" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1359, (MTCY02B10.23), len: 250 aa. Probable FT transcriptional regulatory protein, similar to FT Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and FT to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap)." FT /db_xref="GOA:Q11029" FT /db_xref="InterPro:IPR001054" FT /db_xref="UniProtKB/Swiss-Prot:Q11029" FT /protein_id="CAA99964.1" FT /translation="MFMALRAPMLERMNGLHTDDAPVNWLERRGGRLTSRRRVTLLHAG FT VEHPMRLWGVQSEAITAAMVLSRKVSAIIAGHCGVRLVDQGVGDGFVAAFAHASDAVAC FT ALELHQAPLSPIVLRIGIHTGEAQLVDERIYAGATMNLAAELRDLAHGGQTVMSGATED FT AVLGRLPMRAWLIGLRPMEGSPEGHNFPQSQRIAQLCHPNLRNTFPPLRMRIADASGIP FT YVGRILVNVQVVPHWEGGCAAAGMVLAG" FT CDS 148305..149327 FT /transl_table=11 FT /locus_tag="Rv1360" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv1360, (MTCY02B10.24), len: 340 aa. Probable FT oxidoreductase (EC 1.-.-.-). Similar to Q49598|G1002714 FT coenzyme F420-dependent n5, FT n10-methylenetetrahydromethanopterin reductase from FT Methanopyrus kandleri (349 aa), FASTA scores: opt: 264, FT E(): 4.4e-11, (26.3% identity in 323 aa overlap)." FT /db_xref="InterPro:IPR011251" FT /db_xref="UniProtKB/Swiss-Prot:P64831" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA99965.1" FT /translation="MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEASHDPF FT LPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILGLGTQIRPHIEK FT RFSMPWGHPARRMREFVAALRAIWLAWQDGTKLCFEGEFYTHKIMTPMFTPEPQPYPVP FT RVFIAAVGEAMTEMCGEVADGHLGHPMVSKRYLTEVSVPALLRGLARSGRDRSAFEVSC FT EVMVATGADDAELAAACTATRKQIAFYGSTPAYRKVLEQHGWGDLHPELHRLSKLGEWE FT AMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRVLPIFMAASQECINAALQDFRR FT " FT CDS complement(149400..150590) FT /transl_table=11 FT /gene="PPE19" FT /locus_tag="Rv1361c" FT /standard_name="mtb39b" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1361c, (MTCY02B10.25c), len: 396 aa. PPE19 FT (alternate gene name: mtb39b). Member of the Mycobacterium FT tuberculosis PPE family of glycine-rich proteins, highly FT similar to many e.g. Rv1196|MTCI364.08|PPE18, FASTA scores: FT E(): 0, (84.9% identity in 397 aa overlap); MTCY274.23c FT (42.3% identity in 416 aa overlap); etc. Contains PS00501 FT Signal peptidases I serine active site. Note that FT expression of Rv1361c was demonstrated in lysates by FT immunodetection (see Dillon et al., 1999)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q11031" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55379.1" FT /translation="MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAASA FT FQSVVWGLTTGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGL FT TVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATAT FT EALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFD FT QLSELWKAISPHLSPLSNIVSMLNNHVSMTNSGVSMASTLHSMLKGFAPAAAQAVETAA FT QNGVQAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARA FT LPLTSLTSAAQTAPGHMLGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG" FT misc_feature complement(149805..149828) FT /note="PS00501 Signal peptidases I serine active site" FT CDS complement(150905..151567) FT /transl_table=11 FT /locus_tag="Rv1362c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1362c, (MTCY02B10.26c), len: 220 aa. Possible FT membrane protein, similar to Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9% FT identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc." FT /db_xref="GOA:Q11032" FT /db_xref="UniProtKB/Swiss-Prot:Q11032" FT /protein_id="CAA99967.1" FT /translation="MTDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATEST FT AQKGQRHRDLWRMQVTLKPVPVILILLMLISGGATGWLYLEQYRPDQQTDSGAARAAVA FT AASDGTIALLSYSPDTLDQDFATARSHLAGDFLSYYDQFTQQIVAPAAKQKSLKTTAKV FT VRAAVSELHPDSAVVLVFVDQSTTSKDSPNPSMAASSVMVTLAKVDGNWLITKFTPV" FT CDS complement(151564..152349) FT /transl_table=11 FT /locus_tag="Rv1363c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1363c, (MTCY02B10.27c), len: 261 aa. Possible FT membrane protein, similar to Mycobacterium tuberculosis FT hypothetical proteins Rv1362c|MTCY02B10.26c (25.9% identity FT in 216 aa overlap ); Rv1972|MTV051.10 and Rv0177 etc." FT /db_xref="GOA:Q11033" FT /db_xref="UniProtKB/Swiss-Prot:Q11033" FT /protein_id="CAA99968.1" FT /translation="MAETTEPPSDAGTSQADAMALAAEAEAAEAEALAAAARARARAAR FT LKREALAMAPAEDENVPEEYADWEDAEDYDDYDDYEAADQEAARSASWRRRLRVRLPRL FT STIAMAAAVVIICGFTGLSGYIVWQHHEATERQQRAAAFAAGAKQGVINMTSLDFNKAK FT EDVARVIDSSTGEFRDDFQQRAADFTKVVEQSKVVTEGTVNATAVESMNEHSAVVLVAA FT TSRVTNSAGAKDEPRAWRLKVTVTEEGGQYKMSKVEFVP" FT CDS complement(152640..154601) FT /transl_table=11 FT /locus_tag="Rv1364c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1364c, (MTCY02B10.28c), len: 653 aa. Conserved FT hypothetical protein, some similarity to RSBU_BACSU|P40399 FT sigma factor sibg regulation protein from Bacillus subtilis FT (335 aa), FASTA scores: opt: 224, E(): 2e-07, (25.8% FT identity in 244 aa overlap)." FT /db_xref="GOA:Q11034" FT /db_xref="InterPro:IPR010822" FT /db_xref="UniProtKB/Swiss-Prot:Q11034" FT /protein_id="CAE55380.1" FT /translation="MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAY FT RGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEER FT YFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQ FT ALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAV FT MSQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGH FT PPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEA FT STAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAP FT TPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDV FT SKGIVVAAALAGDGNVRASVIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGT FT TATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQ FT IAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLS FT LVQLPVVGADTEDIFAQE" FT CDS complement(154740..155126) FT /transl_table=11 FT /gene="rsfA" FT /locus_tag="Rv1365c" FT /product="ANTI-ANTI-SIGMA FACTOR RSFA (ANTI-SIGMA FACTOR FT ANTAGONIST) (REGULATOR OF SIGMA F A)" FT /function="REGULATES NEGATIVELY Rv3287c|RSBW|USFX. FT REGULATED BY REDOX POTENTIAL." FT /note="Rv1365c, (MTCY02B10.29c), len: 128 aa. rsfA, FT anti-anti-sigma factor (see citation below), similar to FT other Mycobacterium tuberculosis proteins e.g. FT Rv2638|MTCY441.08 (148 aa), FASTA scores: E(): 0, (53.6% FT identity in 125 aa overlap); Rv1904, Rv3687c. Weak FT similarity to putative anti-anti-sigma factors e.g. FT AF134889|AF134889_1 Streptomyces coelicolor (113 aa), FASTA FT scores: opt: 137, E(): 0.004, (26.0% identity in 100 aa FT overlap)." FT /db_xref="GOA:Q11035" FT /db_xref="InterPro:IPR002645" FT /db_xref="UniProtKB/Swiss-Prot:Q11035" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA99970.1" FT /translation="MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQ FT DLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAVAR FT IIHACGYGDVLPVHPTTESALSAT" FT CDS 155347..156168 FT /transl_table=11 FT /locus_tag="Rv1366" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1366, (MTCY02B10.30), len: 273 aa. Hypothetical FT unknown protein." FT /db_xref="GOA:P64833" FT /db_xref="InterPro:IPR007685" FT /db_xref="UniProtKB/Swiss-Prot:P64833" FT /protein_id="CAA99971.1" FT /translation="MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYA FT EVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDIAG FT VRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVEIQI FT RTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHE FT AEWQHCAEIEYPGQRAMALGEASKNKATVLATTKFRLERAINEAESAGGGG" FT CDS complement(156469..157602) FT /transl_table=11 FT /locus_tag="Rv1367c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN (POSSIBLY INVOLVED IN CELL WALL FT BIOSYNTHESIS)." FT /note="Rv1367c, (MTCY02B12.01c,MTCY02B10.31c), len: 377 aa. FT Conserved hypothetical protein. Some similarity to FT penicillin binding proteins e.g. PBPE_BACSU|P32959 FT penicillin-binding protein 4* (pbp 4*) from Bacillus FT subtilis (451 aa), FASTA scores: E(): 6.9e-06, (23.6% FT identity in 373 aa overlap). Similar to AL031107|SC5A7.06 FT hypothetical protein from Streptomyces coelicolor (409 aa), FT FASTA scores: opt: 675, E(): 0, (40.4% identity in 339 aa FT overlap)." FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/Swiss-Prot:Q11037" FT /protein_id="CAB02645.1" FT /translation="MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAAA FT MSLVDEGKLALRDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAY FT GFSVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSRIED FT APLYQIIDERVLGPAGMTDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSF FT CNAGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAP FT FWVGRGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLYLIQHC FT PDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL" FT CDS 157977..158762 FT /transl_table=11 FT /gene="lprF" FT /locus_tag="Rv1368" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRF" FT /function="UNKNOWN" FT /note="Rv1368, (MTCY02B12.02), len: 261 aa. Probable lprF, FT conserved lipoprotein; similar to Mycobacterium FT tuberculosis hypothetical lipoproteins e.g. FT Rv1270c|Y08C_MYCTU|Q11049 hypothetical 26.4 kDa protein FT cy50.12. (257 aa), FASTA scores: opt: 286, E(): 5.3e-11, FT (26.3% identity in 270 aa overlap), also FT Rv1411c|MTCY21B4.28c, (32.8% identity in 253 aa overlap) FT and Rv2945c. Contains possible N-terminal signal sequence FT and appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013). BELONGS TO THE LPPX/LPRAFG FT FAMILY OF LIPOPROTEINS." FT /db_xref="GOA:P65314" FT /db_xref="InterPro:IPR009830" FT /db_xref="UniProtKB/Swiss-Prot:P65314" FT /protein_id="CAB02646.1" FT /translation="MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTT FT ASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNG FT QAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLG FT AVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNA FT STPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG" FT repeat_region 158906..158908 FT /note="3 bp direct repeat, CGG, at 3' end of IS6110 target FT sequence" FT repeat_region complement(158909..160263) FT /mobile_element="insertion sequence:IS6110-2" FT /note="IS6110-2, len: 1355 bp. Almost identical to FT Insertion sequence IS986 element." FT CDS complement(158951..159835) FT /transl_table=11 FT /locus_tag="Rv1369c" FT /product="PROBABLE TRANSPOSASE" FT /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE FT INSERTION ELEMENT IS6110." FT /note="Rv1369c, (MTCY02B12.03c), len: 294 aa. Probable FT transposase subunit for IS6110, identical from aa 69 to FT TRA9_MYCTU|P19774 putative transposase for insertion FT sequence." FT /db_xref="GOA:P0C5G8" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8" FT /protein_id="CAB02647.1" FT /translation="MRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEH FT ISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPA FT TARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMAT FT SMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSS FT YDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELE FT AAYYAQRQRPAAG" FT CDS complement(159886..160212) FT /transl_table=11 FT /locus_tag="Rv1370c" FT /product="PROBABLE TRANSPOSASE" FT /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE FT INSERTION ELEMENT IS6110." FT /note="Rv1370c, (MTCY02B12.04c), len: 108 aa. Probable FT transposase subunit for IS6110, highly similar to G309867 FT IS401 transposase subunit (107 aa), FASTA scores: opt: 325, FT E(): 2.7e-1 6, (52.9% identity in 102 aa overlap)." FT /db_xref="GOA:P0C5G9" FT /db_xref="InterPro:IPR002514" FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9" FT /protein_id="CAB02648.1" FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD FT RPAR" FT repeat_region 160264..160266 FT /note="3 bp direct repeat, CGG, at 5' end of IS6110 target FT sequence" FT CDS 160316..161785 FT /transl_table=11 FT /locus_tag="Rv1371" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1371, (MTCY02B12.05), len: 489 aa. Probable FT membrane protein. Weak similarity to delta 5 fatty acid FT desaturases e.g. AB022097|AB022097_1 Dictyostelium FT discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052, FT (22.4% identity in 438 aa overlap); and Homo sapiens." FT /db_xref="GOA:P71799" FT /db_xref="HSSP:1ICC" FT /db_xref="InterPro:IPR001199" FT /db_xref="UniProtKB/TrEMBL:P71799" FT /protein_id="CAB02649.1" FT /translation="MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISK FT HPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFL FT FKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFA FT VQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALS FT LVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVD FT VFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLW FT VSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVH FT HVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKER FT HWGFVREHCSPAALKASASYVVAGFVGIGSV" FT CDS 161782..162963 FT /transl_table=11 FT /locus_tag="Rv1372" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1372, (MTCY02B12.06), len: 393 aa. Conserved FT hypothetical protein, similar to several chalcone synthases FT e.g. CHS2_GERHY|P48391 chalcone synthase 2 from gerbra FT hybrid (402 aa), FASTA scores: opt: 511, E(): 7e-26, (28.4% FT identity in 380 aa overlap). Also similar to Mycobacterium FT tuberculosis hypothetical chalcone synthases, Rv1665, FT Rv1660." FT /db_xref="GOA:Q7D8I1" FT /db_xref="InterPro:IPR016038" FT /db_xref="PDB:1TED" FT /db_xref="UniProtKB/TrEMBL:Q7D8I1" FT /protein_id="CAE55381.1" FT /translation="MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRR FT VVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRD FT RMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSP FT SISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHS FT LFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENL FT PGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDV FT LARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR" FT CDS 162969..163949 FT /transl_table=11 FT /locus_tag="Rv1373" FT /product="GLYCOLIPID SULFOTRANSFERASE" FT /function="INVOLVED IN SULFATION: ACTIVITY TOWARDS TYPICAL FT CERAMIDE GLYCOLIPIDS AND TREHALOSE GLYCOLIPIDS." FT /EC_number="2.8.2.-" FT /note="Rv1373, (MTCY02B12.07), len: 326 aa. Glycolipid FT sulfotransferase (EC 2.8.2.-) (see citation below); slight FT similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 FT estrogen sulfotransferase from Cavia porcellus (Guinea pig) FT (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, FT (24.5% identity in 294 aa overlap)." FT /db_xref="GOA:P71801" FT /db_xref="InterPro:IPR000863" FT /db_xref="UniProtKB/Swiss-Prot:P71801" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02651.1" FT /translation="MNSEHPMTDRVVYRSLMADNLRWDALQLRDGDIIISAPSKSGLTW FT TQRLVSLLVFDGPDLPGPLSTVSPWLDQTIRPIEEVVATLDAQQHRRFIKTHTPLDGLV FT LDDRVSYICVGRDPRDAAVSMLYQSANMNEDRMRILHEAVVPFHERIAPPFAELGHARS FT PTEEFRDWMEGPNQPPPGIGFTHLKGIGTLANILHQLGTVWVRRHLPNVALFHYADYQA FT DLAGELLRPARVLGIAATRDRARDLAQYATLDAMRSRASEIAPNTTDGIWHSDERFFRR FT GGSGDWQQFFTEAEHLRYYHRINQLAPPDLLAWAHEGRRGYDPAN" FT CDS complement(164029..164487) FT /transl_table=11 FT /locus_tag="Rv1374c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1374c, (MTCY02B12.08c), len: 152 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR018271" FT /db_xref="UniProtKB/TrEMBL:P71802" FT /protein_id="CAB02652.2" FT /translation="MVTSVADENVASRIASWGTGPAPDPRLDYAHAHLKGRRGRSPARP FT NAPIGARSFAVGRKICRVERFTLLEHGFVGHALHRVPCAGLVALVMSACSLAVCREVGN FT YAQRRVGRFAFFEQTFVRHALTPRCSRTDSKTSYTQLNRICKFPPHWV" FT CDS 164789..166108 FT /transl_table=11 FT /locus_tag="Rv1375" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1375, (MTCY02B12.09), len: 439 aa. Conserved FT hypothetical protein, similar to hypothetical proteins from FT several organisms e.g. Q52871|U39409 Rhizobium FT leguminosarum (420 aa), FASTA scores: E(): 2e-30, (34.4% FT identity in 378 aa overlap)." FT /db_xref="InterPro:IPR003776" FT /db_xref="UniProtKB/Swiss-Prot:P71803" FT /protein_id="CAB02636.1" FT /translation="MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWPS FT RVLGSADPTTIAHRHGTHRITSPDETWLALQPFLAPAGITGVADVTWLDCLGIPTVQAV FT RPASLTLSVSQGKAASYRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYDPAQ FT LRHRPGSLYHAGVKLDWMVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDTTGLA FT SGNCYDEATLHALYEVMERHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDAGDDVD FT LARIDVWDGYYCFAAELTSATLEVTFGGFGLHHDPNVALSRAITEAAQSRITAISGARE FT DLPSAIYHRFGRVHTYAKARKTSLRLNRARPTPWRVPDVDSLPELVASAATAVANRSGT FT EPLAVVCDFADACVPVVKVLAPGLVLSSASPMRTPLQEAE" FT CDS 166105..167598 FT /transl_table=11 FT /locus_tag="Rv1376" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1376, (MTCY02B12.10), len: 497 aa. Conserved FT hypothetical protein, some similarity to hypothetical FT proteins from several organisms e.g. Q52872|U39409 FT Rhizobium leguminosarum (247 aa), FASTA scores: E(): FT 2.1e-12, (34.7% identity in 219 aa overlap)." FT /db_xref="InterPro:IPR016845" FT /db_xref="UniProtKB/TrEMBL:P71804" FT /protein_id="CAB02637.1" FT /translation="MTACGRIVVTAGPTISAADIRSVVPDAEVAPPIAFGQALSYDLRS FT GDTLLIVDGLFFQQPSVRHKELLTLMADGVRVVGSSSMGALRAAELHPFGMEGYGWVFE FT SYRDGVLEADDEVGVVHGDADDGYPVFVDALVNMRHTLARAVATGVVCSELAERIIETA FT RATPFTMRTWARLLSEVGAPDQRGLAAQLRSLRVDVKHADALLALRQLGQRPRVEPLRP FT GPPPTVWSRRWRQRWAPPTSVAASADHGESFVDVTDLEVLSFLSVSSVDYWAYRPALQQ FT VAAWYWTLKHPEQSGSVGERAARAVAEVASEGYGRALEFIAYRYALATGIIDETGFPEA FT VAAHWLTTEERHGLGNDPISISARVITRTLFVVRLLPAIDHFLDLLRKDSRLPRWRAMA FT AHALCKRDDLARQKPHLNLGRPDPTQLKRLFGARWGTQVNRIELARRGLMTEDAFYAAA FT TPFAVAAVDDQLPRIEVGTLGPAPLSADVPERHFDFGSV" FT CDS complement(167536..168174) FT /transl_table=11 FT /locus_tag="Rv1377c" FT /product="PUTATIVE TRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="2.-.-.-" FT /note="Rv1377c, (MTCY02B12.11c), len: 212 aa. Putative FT transferase (EC 2.-.-.-), similar to YQEM_BACSU|P54458 FT hypothetical 28.3 kDa protein from Bacillus subtilis (247 FT aa), FASTA scores: opt: 221, E(): 7.6e-08, (30.6% identity FT in 144 aa overlap); some similarity to methyltransferases, FT also similar to Mycobacterium tuberculosis hypothetical FT proteins Rv0560c, Rv3699, and Rv2675c (~ 39.1% identity in FT 197 aa overlap)." FT /db_xref="GOA:P71805" FT /db_xref="HSSP:1UFK" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:P71805" FT /protein_id="CAB02638.1" FT /translation="MPGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGWV FT HGDVLDIGCGLGDNAIYLARNGYQVTGLDISPTALTTAKRRASDAGVDVKFAVGDATKL FT TGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRATRPGATLLLSCFSNAMPPDEEWPRS FT TVSEQTLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRGS" FT CDS complement(168185..169612) FT /transl_table=11 FT /locus_tag="Rv1378c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN. THOUGHT TO BE REGULATED BY FT Rv2720|LEXA." FT /note="Rv1378c, (MTCY02B12.12c), len: 475 aa. Conserved FT hypothetical protein, similar to other Mycobacterium FT tuberculosis hypothetical proteins e.g. Rv3074|MTCY22D7.07C FT (424 aa), FASTA scores: E(): 0, (73.0% identity in 429 aa FT overlap)." FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:P71806" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02639.1" FT /translation="MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPRWPRPAILE FT HMFDLVSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEADAGVP FT ARRRGRGVASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALEVGRLSEWRATLIVR FT ESACLDVEDRRALDAELCADMSALDGMGDARIAAAARAIAYRLDAQAVVERAARAETER FT TVTIRPAPDTMTWVTALLPVARGVSVYAALKRAADTTFDDRTRGQVMADTLVERVTGQP FT AEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVADTRSRATLRRL FT YRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMPYCDAPIRHRDHAQPHHRGGPTT FT ATNGLGSCERCNYVKEAPGWRVSTDTDETGRHTAEFTTPTGMYYHCTAPPLPGPLEIDV FT SQVEARIGVALTHLHAA" FT CDS 169611..170192 FT /transl_table=11 FT /gene="pyrR" FT /locus_tag="Rv1379" FT /product="PROBABLE PYRIMIDINE OPERON REGULATORY PROTEIN FT PYRR" FT /function="BINDS TO THE CONSERVED SEQUENCE IN THE PYR FT OPERON MRNA AND DISRUPTS THE ANTITERMINATOR, PERMITTING FT TERMINATOR HAIRPIN FORMATION AND PROMOTING TRANSCRIPTION FT TERMINATION" FT /note="Rv1379, (MTCY02B12.13), len: 193 aa. Probable pyrR, FT pyrimidine operon regulatory protein, similar to FT PYRR_BACCL|P41007 pyrimidine operon regulatory protein from FT Bacillus caldolyticus (179 aa), FASTA scores: opt: 544, FT E(): 1.1e-30, (54.2% identity in 179 aa overlap)." FT /db_xref="GOA:P65941" FT /db_xref="InterPro:IPR000836" FT /db_xref="PDB:1W30" FT /db_xref="UniProtKB/Swiss-Prot:P65941" FT /protein_id="CAB02640.1" FT /translation="MGAAGDAAIGRESRELMSAADVGRTISRIAHQIIEKTALDDPVGP FT DAPRVVLLGIPTRGVTLANRLAGNITEYSGIHVGHGALDITLYRDDLMIKPPRPLASTS FT IPAGGIDDALVILVDDVLYSGRSVRSALDALRDVGRPRAVQLAVLVDRGHRELPLRADY FT VGKNVPTSRSESVHVRLREHDGRDGVVISR" FT CDS 170189..171148 FT /transl_table=11 FT /gene="pyrB" FT /locus_tag="Rv1380" FT /product="PROBABLE ASPARTATE CARBAMOYLTRANSFERASE PYRB FT (ATCase) (Aspartate transcarbamylase)" FT /function="INVOLVED IN PYRIMIDINE BIOSYNTHESIS (SECOND FT STEP) [CATALYTIC ACTIVITY : CARBAMOYL PHOSPHATE + FT L-ASPARTATE = PHOSPHATE + N-CARBAMOYL-L-ASPARTATE]" FT /EC_number="2.1.3.2" FT /note="Rv1380, (MTCY02B12.14), len: 319 aa. Probable pyrB, FT aspartate carbamoyltransferase (EC 2.1.3.2), similar to FT many e.g. PYRB_BACCL|P41008 aspartate carbamoyltransferase FT from Bacillus caldolyticus (308 aa), FASTA scores, opt: FT 639, E(): 7.3e-36, (39.5% identity in 311 aa overlap). FT Contains PS00097 Aspartate and ornithine FT carbamoyltransferases signature. BELONGS TO THE FT ATCASES/OTCASES FAMILY." FT /db_xref="GOA:P65613" FT /db_xref="HSSP:1GQ3" FT /db_xref="InterPro:IPR006131" FT /db_xref="UniProtKB/Swiss-Prot:P65613" FT /protein_id="CAB02641.1" FT /translation="MTPRHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRGR FT TVVTMFYENSTRTRVSFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGADAL FT IIRHPASGAAHLLAQWTGAHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRI FT VIVGDILHSRVARSNVMLLDTLGAEVVLVAPPTLLPVGVTGWPATVSHDFDAELPAADA FT VLMLRVQAERMNGGFFPSVREYSVRYGLTERRQAMLPGHAVVLHPGPMVRGMEITSSVA FT DSSQSAVLQQVSNGVQVRMAVLFHVLVGAQDAGKEGAA" FT misc_feature 170339..170362 FT /note="PS00097 Aspartate and ornithine FT carbamoyltransferases signature" FT CDS 171145..172437 FT /transl_table=11 FT /gene="pyrC" FT /locus_tag="Rv1381" FT /product="PROBABLE DIHYDROOROTASE PYRC (DHOase)" FT /function="INVOLVED IN PYRIMIDINE BIOSYNTHESIS (THIRD STEP) FT [CATALYTIC ACTIVITY: (S)-DIHYDROOROTATE + H(2)O = FT N-CARBAMOYL-L-ASPARTATE]" FT /EC_number="3.5.2.3" FT /note="Rv1381, (MTCY02B12.15), len: 430 aa. Probable pyrC, FT dihydroorotase (EC 3.5.2.3), similar to many e.g. FT PYRC_BACCL|P46538 (40.5% identity in 395 aa overlap). FT Contains PS00483 Dihydroorotase signature 2. BELONGS TO THE FT DHOASE FAMILY. SUBFAMILY 2." FT /db_xref="GOA:P71809" FT /db_xref="HSSP:1ONW" FT /db_xref="InterPro:IPR002195" FT /db_xref="UniProtKB/Swiss-Prot:P71809" FT /protein_id="CAB02642.1" FT /translation="MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDAT FT GHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDH FT VWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRR FT ALEYATGLGVLIAQHAEEPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARD FT AGARVHICHASAAGTVEILKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLR FT EASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVA FT PGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSA FT NTPFESMSLPATVTATLLRGKVTARDGKIRA" FT misc_feature 172048..172083 FT /note="PS00483 Dihydroorotase signature 2" FT CDS 172434..172931 FT /transl_table=11 FT /locus_tag="Rv1382" FT /product="PROBABLE EXPORT OR MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1382, (MTCY02B12.16), len: 165 aa. Possible FT exported or membrane protein, hydrophobic domain at FT N-terminus." FT /db_xref="UniProtKB/TrEMBL:P71810" FT /protein_id="CAB02643.1" FT /translation="MNSGTLAGSLIFAAVLVMLIAVLARLMMRGWRRRSERQAELLGDL FT PDVPEHVSSATVTTRGLYVGATLSPAWNERVTVGDLGYRSKAVLTRYPSGIMVERARAQ FT PIWIPTESIAAIRMERGVAGKVVAGIGILAIRWRLPSGTEIDVGFRADNRDEYQEWLEE FT PV" FT CDS 172928..174058 FT /transl_table=11 FT /gene="carA" FT /locus_tag="Rv1383" FT /product="PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN FT CARA (Carbamoyl-phosphate synthetase glutamine chain)" FT /function="INVOLVED IN BOTH ARGININE AND PYRIMIDINE FT BIOSYNTHESIS [CATALYTIC ACTIVITY : 2 ATP + L-GLUTAMINE + FT CO(2) + H(2)O = 2 ADP + PHOSPHATE + GLUTAMATE + CARBAMOYL FT PHOSPHATE]" FT /EC_number="6.3.5.5" FT /note="Rv1383, (MTCY02B12.17), len: 376 aa. Probable carA, FT Carbamoyl-phosphate synthase small chain (EC 6.3.5.5), FT similar to many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate FT synthase small chain from Escherichia coli (382 aa), FASTA FT scores: opt: 796, E(): 0, (45.5% identity in 382 aa FT overlap). Contains PS00442 Glutamine amidotransferases FT class-I active site. THE GATASE DOMAIN BELONGS TO TYPE-1 FT GLUTAMINE AMIDOTRANSFERASES. SUBUNIT: COMPOSED OF TWO FT CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE FT HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS USED BY THE FT LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL FT PHOSPHATE." FT /db_xref="GOA:P71811" FT /db_xref="HSSP:1CE8" FT /db_xref="InterPro:IPR000991" FT /db_xref="UniProtKB/Swiss-Prot:P71811" FT /protein_id="CAB02644.1" FT /translation="MSKAVLVLEDGRVFTGRPFGATGQALGEAVFSTGMSGYQETLTDP FT SYHRQIVVATAPQIGNTGWNGEDSESRGERIWVAGYAVRDPSPRASNWRATGTLEDELI FT RQRIVGIAGIDTRAVVRHLRSRGSMKAGVFSDGALAEPADLIARVRAQQSMLGADLAGE FT VSTAEPYVVEPDGPPGVSRFTVAALDLGIKTNTPRNFARRGIRCHVLPASTTFEQIAEL FT NPHGVFLSNGPGDPATADHVVALTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGH FT RGINIPVVDHATGRVAVTAQNHGFALQGEAGQSFATPFGPAVVSHTCANDGVVEGVKLV FT DGRAFSVQYHPEAAAGPHDAEYLFDQFVELMAGEGR" FT misc_feature 173690..173725 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT CDS 174058..177405 FT /transl_table=11 FT /gene="carB" FT /locus_tag="Rv1384" FT /product="PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN FT CARB (Carbamoyl-phosphate synthetase ammonia chain)" FT /function="INVOLVED IN BOTH ARGININE AND PYRIMIDINE FT BIOSYNTHESIS [CATALYTIC ACTIVITY : 2 ATP + L-GLUTAMINE + FT CO(2) + H(2)O = 2 ADP + PHOSPHATE + GLUTAMATE + CARBAMOYL FT PHOSPHATE.]" FT /EC_number="6.3.5.5" FT /note="Rv1384, (MTCY02B12.18-MTCY21B4.01), len: 1115 aa. FT Probable carB, Carbamoyl-phosphate synthase large chain (EC FT 6.3.5.5), similar to many e.g. CARB_ECOLI|P00968 E. coli FT (1072 aa), FASTA scores: E(): 0, (52.3% identity in 1118 aa FT overlap). Contains two PS00867 Carbamoyl-phosphate synthase FT subdomain signature 2 and PS00866 FT Carbamoyl-phosphatesynthase subdomain signature 1. SUBUNIT: FT COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN FT PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS FT USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE FT CARBAMOYL PHOSPHATE." FT /db_xref="GOA:P57689" FT /db_xref="HSSP:1CS0" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/Swiss-Prot:P57689" FT /protein_id="CAE55382.1" FT /translation="MPRRTDLHHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLQVS FT LVNSNPATIMTDPEFADHTYVEPITPAFVERVIAQQAERGNKIDALLATLGGQTALNTA FT VALYESGVLEKYGVELIGADFDAIQRGEDRQRFKDIVAKAGGESARSRVCFTMAEVRET FT VAELGLPVVVRPSFTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGWKEFE FT LELMRDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAILREVG FT VDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEI FT VNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFVEAL FT GKVMRSLETTRAGFWTAPDPDGGIEEALTRLRTPAEGRLYDIELALRLGATVERVAEAS FT GVDPWFIAQINELVNLRNELVAAPVLNAELLRRAKHSGLSDHQIASLRPELAGEAGVRS FT LRVRLGIHPVYKTVDTCAAEFEAQTPYHYSSYELDPAAETEVAPQTERPKVLILGSGPN FT RIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEV FT YHAEMESGSGGPGVAGVIVQLGGQTPLGLAHRLADAGVPIVGTPPEAIDLAEDRGAFGD FT LLSAAGLPAPKYGTATTFAQARRIAEEIGYPVLVRPSYVLGGRGMEIVYDEETLQGYIT FT RATQLSPEHPVLVDRFLEDAVEIDVDALCDGAEVYIGGIMEHIEEAGIHSGDSACALPP FT VTLGRSDIAKVRKATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT FT AVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAARNAPIAVKEAVLPFHRFRRADGA FT AIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQGTVFVSVANRDKRSLVFP FT VKRLADLGFRVLATEGTAEMLRRNGIPCDDVRKHFEPAQPGRPTMSAVDAIRAGEVNMV FT INTPYGNSGPRIDGYEIRSAAVAGNIPCITTVQGASAAVQGIEAGIRGDIGVRSLQELH FT RVIGGVER" FT misc_feature 174961..174984 FT /note="PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2" FT misc_feature 176227..176271 FT /note="PS00866 Carbamoyl-phosphate synthase subdomain FT signature 1" FT misc_feature 176614..176637 FT /note="PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2" FT CDS 177402..178226 FT /transl_table=11 FT /gene="pyrF" FT /locus_tag="Rv1385" FT /product="PROBABLE OROTIDINE 5'-PHOSPHATE DECARBOXYLASE FT PYRF (OMP decarboxylase) (OMPdecase)" FT /function="INVOLVED IN THE BIOSYNTHESIS OF PYRIMIDINES FT [CATALYTIC ACTIVITY : OROTIDINE 5'-PHOSPHATE = UMP + FT CO(2)]" FT /EC_number="4.1.1.23" FT /note="Rv1385, (MTCY21B4.02), len: 274 aa. Probable pyrF, FT orotidine 5'-phosphate decarboxylase (EC 4.1.1.23), FT identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 FT aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase FT active site. BELONGS TO THE OMP DECARBOXYLASE FAMILY." FT /db_xref="GOA:P0A5M6" FT /db_xref="InterPro:IPR001754" FT /db_xref="UniProtKB/Swiss-Prot:P0A5M6" FT /protein_id="CAB02190.1" FT /translation="MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFC FT DICVRAFADFAVVKPQVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMS FT AYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNA FT AADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQG FT GRPEALGGLGGAASSQLLPAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV" FT misc_feature 177669..177710 FT /note="PS00156 Orotidine 5'-phosphate decarboxylase active FT site" FT CDS 178421..178729 FT /transl_table=11 FT /gene="PE15" FT /locus_tag="Rv1386" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1386, (MTCY21B4.03), len: 102 aa. Member of FT Mycobacterium tuberculosis PE family (see Brennan & Delogu FT 2002), similar to many e.g. G913039 ORF 3' OF PGRS TANDEM FT REPEAT (polymorphic GC-rich sequence) (100 aa), FASTA FT scores: opt: 149, E(): 0.0013, (31.5% identity in 92 aa FT overlap); also similar to Q49943|U1756A (99 aa) (34.7% FT identity in 95 aa overlap) and G466937|U1620K (100 aa) FT (36.2% identity in 69 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:P0A682" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55383.1" FT /translation="MTLRVVPESLAGASAAIEAVTARLAAAHAAAAPFIAAVIPPGSDS FT VSVCNAVEFSVHGSQHVAMAAQGVEELGRSGVGVAESGASYAARDALAAASYLSGGL" FT CDS 178726..180345 FT /transl_table=11 FT /gene="PPE20" FT /locus_tag="Rv1387" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1387, (MTCY21B4.04), len: 539 aa. Member of FT Mycobacterium tuberculosis PPE family of proteins, similar FT to many e.g. Y05F_MYCTU|Q10892 hypothetical 46.9 kd protein FT cy251.15 (463 aa), FASTA scores: E(): 4.2e-26, (37.7% FT identity in 531 aa overlap); similar also to MTCY274.23c FT (37.5% identity in 168 aa overlap). Contains PS00343 FT Gram-positive cocci surface proteins 'anchoring' FT hexapeptide." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q7D8H6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55384.1" FT /translation="MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAAS FT EVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMAAQQHVVIEAYTAAVE FT LMPTQVELAANQIKLAVLVATNFFGINTIPIAINEAEYVEMWVRAATTMATYSTVSRSA FT LSAMPHTSPPPLILKSDELLPDTGEDSDEDGHNHGGHSHGGHARMIDNFFAEILRGVSA FT GRIVWDPVNGTLNGLDYDDYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFLL FT YVVVVDLPTHIAQIATWLGQYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPSAAIPAV FT VPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAAGPTPPATGFGGFPP FT YLVGGGGPGIGFGSGQSAHAKAAASDSAAAESAAQASARAQARAARRGRSAAKARGHRD FT EFVTMDMGFDAAAPAPEHQPGARASDCGAGPIGFAGTVRKEAVVKAAGLTTLAGDDFGG FT GPTMPMMPGTWTHDQGVFDEHR" FT misc_feature 179272..179289 FT /note="PS00343 Gram-positive cocci surface proteins FT 'anchoring' hexapeptide" FT CDS 180651..181223 FT /transl_table=11 FT /gene="mihF" FT /locus_tag="Rv1388" FT /product="PUTATIVE INTEGRATION HOST FACTOR MIHF" FT /function="UNKNOWN" FT /note="Rv1388, (MTCY21B4.05), len: 190 aa. Putative mihF, FT integration host factor. Almost identical to, but longer FT than, P96802|U75344 Mycobacterium smegmatis integration FT host factor (mIHF) for mycobacteriophage L5 (105 aa), FASTA FT scores: E(): 0, (96.1% identity in 102 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P71658" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02193.1" FT /translation="MLGNTIHVPCQPCRHGHGAPSRGLRGRPADRWPVARATPTLHVCP FT QNQGVGLDFVRKPEYGRLRWPAYPAGTNNDRLISMRDGGIVALPQLTDEQRAAALEKAA FT AARRARAELKDRLKRGGTNLTQVLKDAESDEVLGKMKVSALLEALPKVGKVKAQEIMTE FT LEIAPTRRLRGLGDRQRKALLEKFGSA" FT CDS 181358..181984 FT /transl_table=11 FT /gene="gmk" FT /locus_tag="Rv1389" FT /product="PROBABLE GUANYLATE KINASE GMK" FT /function="ESSENTIAL FOR RECYCLING GMP AND INDIRECTLY, CGMP FT [CATALYTIC ACTIVITY : ATP + GMP = ADP + GDP]" FT /EC_number="2.7.4.8" FT /note="Rv1389, (MTCY21B4.06), len: 208 aa. Probable gmk, FT guanylate kinase (EC 2.7.4.8), similar to e.g. FT KGUA_ECOLI|P24234 guanylate kinase from Escherichia coli FT (207 aa), FASTA scores: opt: 424, E(): 6.6e-20, (35.9% FT identity in 184 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), PS00856 Guanylate FT kinase signature. BELONGS TO THE GUANYLATE KINASE FAMILY." FT /db_xref="GOA:P0A5I4" FT /db_xref="InterPro:IPR008145" FT /db_xref="PDB:1S4Q" FT /db_xref="UniProtKB/Swiss-Prot:P0A5I4" FT /protein_id="CAB02172.1" FT /translation="MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERI FT PNLHFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQ FT PVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVI FT QRRLDTARIELAAQGDFDKVVVNRRLESACAELVSLLVGTAPGSP" FT misc_feature 181439..181462 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 181520..181573 FT /note="PS00856 Guanylate kinase signature" FT CDS 182050..182382 FT /transl_table=11 FT /gene="rpoZ" FT /locus_tag="Rv1390" FT /product="PROBABLE DNA-DIRECTED RNA POLYMERASE (OMEGA FT CHAIN) RPOZ (TRANSCRIPTASE OMEGA CHAIN) (RNA POLYMERASE FT OMEGA SUBUNIT)" FT /function="PROMOTES RNA POLYMERASE ASSEMBLY. LATCHES THE FT N-AND C-TERMINAL REGIONS OF THE BETA' SUBUNIT THEREBY FT FACILTATING ITS INTERACTION WITH THE BETA AND ALPHA FT SUBUNITS (BY SIMILARITY) [CATALYTIC ACTIVITY: N nucleoside FT triphosphate = N diphosphate + {RNA}N]." FT /EC_number="2.7.7.6" FT /note="Rv1390, (MTCY21B4.07), len: 110 aa. Probable rpoZ, FT DNA-directed RNA polymerase omega chain (EC 2.7.7.6). FT BELONGS TO THE RNA POLYMERASE OMEGA CHAIN FAMILY." FT /db_xref="GOA:P66721" FT /db_xref="InterPro:IPR006110" FT /db_xref="UniProtKB/Swiss-Prot:P66721" FT /protein_id="CAB02173.1" FT /translation="MSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELLD FT RVSSKYALVIYAAKRARQINDYYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLL FT EHTEGE" FT CDS 182398..183654 FT /transl_table=11 FT /gene="dfp" FT /locus_tag="Rv1391" FT /product="PROBABLE DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN FT HOMOLOG DFP" FT /function="FLAVOPROTEIN AFFECTING SYNTHESIS OF DNA AND FT PANTOTHENATE METABOLISM" FT /note="Rv1391, (MTCY21B4.08), len: 418 aa. Probable dfp, FT DNA/pantothenate metabolism flavoprotein homolog , similar FT to many e.g. DFP_ECOLI|P24285 Escherichia coli (430 aa), FT FASTA scores: opt: 763, E(): 0, (40.2% identity in 408 aa FT overlap)." FT /db_xref="GOA:P67733" FT /db_xref="HSSP:1MVN" FT /db_xref="InterPro:IPR003382" FT /db_xref="UniProtKB/Swiss-Prot:P67733" FT /protein_id="CAB02174.1" FT /translation="MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTES FT ALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRA FT DDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSG FT AGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQG FT YAVARVAAQRGADVTLIAGHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAA FT AVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAET FT GDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKT FT LMASRIVDAIVTFLAGCSS" FT CDS 183782..184993 FT /transl_table=11 FT /gene="metK" FT /locus_tag="Rv1392" FT /product="PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE METK FT (MAT) (AdoMet synthetase) (Methionine adenosyltransferase)" FT /function="Involved in the activated Methyl cycle. FT Catalyzes the formation of S-adenosylmethionine from FT methionine and ATP. The overall synthetic reaction is FT composed of two sequential steps, AdoMet formation and the FT subsequent tripolyphosphate hydrolysis which occurs prior FT to release of AdoMet from the enzyme. [CATALYTIC ACTIVITY : FT ATP + L-METHIONINE + H(2)O = PHOSPHATE + DIPHOSPHATE + FT S-ADENOSYL-L-METHIONINE]" FT /EC_number="2.5.1.6" FT /note="Rv1392, (MTCY21B4.09), len: 403 aa. Probable metK, FT S-adenosylmethionine synthetase (EC 2.5.1.6), similar to FT many e.g. METK_STAAU|P50307 Staphylococcus aureus (397 aa), FT FASTA scores: opt: 1484, E(): 0, (58.0% identity in 400 aa FT overlap). Contains PS00376 S-adenosylmethionine synthetase FT signature 1, PS00377 S-adenosylmethionine synthetase FT signature 2. BELONGS TO THE ADOMET SYNTHETASE FAMILY." FT /db_xref="GOA:P77899" FT /db_xref="HSSP:1MXB" FT /db_xref="InterPro:IPR002133" FT /db_xref="UniProtKB/Swiss-Prot:P77899" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02194.1" FT /translation="MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVE FT TLVTTGQVHVVGEVTTSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQ FT SPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELMPLPIALAHRLSRR FT LTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVVISTQHAADIDLEKTLDPDIREK FT VLNTVLDDLAHETLDASTVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGG FT AFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTET FT EDPVKIEKAIGEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDL FT KRAI" FT misc_feature 184172..184189 FT /note="PS00376 S-adenosylmethionine synthetase signature 1" FT misc_feature 184616..184642 FT /note="PS00377 S-adenosylmethionine synthetase signature 2" FT CDS complement(185066..186544) FT /transl_table=11 FT /locus_tag="Rv1393c" FT /product="PROBABLE MONOXYGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.14.13.-" FT /note="Rv1393c, (MTCY21B4.10c), len: 492 aa. Probable FT monooxygenase (EC 1.14.13.-), similar to others e.g. FT CYMO_ACISP|P12015 cyclohexanone monooxygenase (EC FT 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores: FT E(): 0, (33.0% identity in 473 aa overlap); also to FT Rv3083|MTCY31.20|E241788 hypothetical 55.0 kDa protein from FT Mycobacterium tuberculosis (495 aa) (36.3% identity in 490 FT aa overlap); and Rv0565c, Rv3854c, Rv3049c, Rv0892." FT /db_xref="GOA:P71662" FT /db_xref="InterPro:IPR002937" FT /db_xref="UniProtKB/TrEMBL:P71662" FT /protein_id="CAB02175.1" FT /translation="MMPDYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTWH FT WNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYGIRSRIRLNTKV FT LAAEFDDEHSLWRVQTDPGGEITARFLISACGILTVPKLPDIDGVDSFEGVTMHTARWD FT HTQDLTGKRVGIIGTGASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFDVPLPTAVRWAM FT RIPGGKAVHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHDPVVREQLT FT PRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHEIDVLVLATGF FT KVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPGYPNFFTVFGPYGYVGSSYF FT ALIETQAHHIIRCLKRARRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSY FT YFDKNGDVPLRPTTTVEAYWRSRRFDLGDYRISS" FT CDS complement(186541..187926) FT /transl_table=11 FT /gene="cyp132" FT /locus_tag="Rv1394c" FT /product="PROBABLE CYTOCHROME P450 132 CYP132" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. IT OXIDIZES A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv1394c, (MT1439, MTCY21B4.11c), len: 461 aa. FT Probable cyp132, cytochrome P450 132 (EC 1.14.-.-). Some FT similarity to others e.g. CP4B_HUMAN|P13584 human FT cytochrome p450 (511 aa), FASTA scores: opt: 486, E(): FT 7.4e-21, (28.6% identity in 423 aa overlap); etc. Contains FT PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. MAY BELONG TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P77900" FT /db_xref="HSSP:1JPZ" FT /db_xref="InterPro:IPR002401" FT /db_xref="UniProtKB/Swiss-Prot:P77900" FT /protein_id="CAE55385.1" FT /translation="MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGSD FT ITRFRCAGRRFVSISHPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWARH FT RGALNSTFARRHLRGLVGLMIDPIADVTAARVPGAQFDMHQSMVETTLRVVANALFSQD FT FGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLREMQEI FT TLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGHETTAN FT AMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSVWI FT IAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPTDRPRCAY FT LPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRPKHGVHVIG FT RRR" FT misc_feature complement(186694..186723) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS 188004..189038 FT /transl_table=11 FT /locus_tag="Rv1395" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1395, (MTCY21B4.12), len: 344 aa. Probable FT transcriptional regulatory protein (see citation below), FT similar to many e.g. URER_PROMI|Q02458 urease operon FT transcriptional activator from Proteus mirabilis (293 aa), FT FASTA scores: E():1.5e-08, (41.7% identity in 84 aa FT overlap); YHIX_ECOLI|P37639 hypothetical transcriptional FT regulatory protein from Escherichia coli (274 aa), FASTA FT scores: opt: 238, E(): 3.5e-09, (27.3% identity in 249 aa FT overlap); and G296916|X68281 POSSIBLE VIRULENCE-REGULATING FT protein from Mycobacterium tuberculosis (339 aa), FASTA FT scores: opt: 228, E(): 1.9e-08, (27.0% identity in 278 aa FT overlap). Helix turn helix motif present, aa 261-282 (+4.68 FT SD). BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL FT REGULATORS. 3' part corrected since first submission (-14 FT aa)." FT /db_xref="GOA:P68913" FT /db_xref="InterPro:IPR018060" FT /db_xref="UniProtKB/Swiss-Prot:P68913" FT /protein_id="CAE55386.1" FT /translation="MGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADL FT DDPDAVVGALDEITAVRRLLARLPDDAGIGIDVGSRFALTHFGLFGFAVMSCGTLRELL FT TIAMRYFALTTMHVDITLFETADDCLVELDASHLPADVRGFFIERDIAGIIATTTSFAL FT PLAAKYADQVSAELAVDAELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQADRH FT TLEMCIAQCDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRLA FT EEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEY FT SRRG" FT CDS complement(189084..190814) FT /transl_table=11 FT /gene="PE_PGRS25" FT /locus_tag="Rv1396c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1396c, (MTCY21B4.13c), len: 576 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see Brennan & Delogu 2002), strong FT similarity to many e.g. glycine rich protein FT MTCY130.10C|E245019 (603 aa), FASTA scores: opt: 1945, E(): FT 0, (57.5% identity in 619 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A, similar to other PGRS-type FT sequences." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:P71664" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55387.1" FT /translation="MSFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAAGAD FT EVSAAVAALFSGHAQTYQALRTQAAAFHQQIVQTLTSTAGAYASAEAANVEQQLLGAIN FT APTMALLGRPLIGHGADGAPGTGQAGGAGGILYGNGGNGGSGATGQAGGAGGAAGLIGH FT GGAGGLGGTGASGGAGGAGGWLWGNGGAGGNGGVGVAGDPGGVGGAGGAGGAAGLWGSG FT GSGGTGGQGGVGGGKSGDGGTGGIGGAGGGGGWLHGDGGAGGHGGQGGTGVSSGGNGGA FT GGTGGDGRGLSGSGGAGGRGGQTGVGGKVGENNFGGAGGAGGTGGLIGNGGAGGNGGQG FT AISGAGGAGGNAWLIGDGGAGGNGGDIRGQGGGAGGAGGAGGQLIGNGGTGGAGGTVTS FT PNGLGGAGGAGGSAGLIGHGGTGGAGGHSAQGPDGNGGIGGAGGAGGNGGQLYGTGGTG FT GTGGKGGDGFGVFGKGGAGGTGGRGGAAGLIGDAGTGGTGGKGGTAGEDGTGGNGGTGG FT NGGAAVLIGNGGGGGAGGNGGAGNDGTPGNGGGGGVGGTGGTLFGQPGQPGPPGQPGPA FT " FT misc_feature complement(190101..190124) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(191069..191470) FT /transl_table=11 FT /locus_tag="Rv1397c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1397c, (MTCY21B4.14c), len: 133 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT protein MTCY159.08C|Rv2548 (125 aa), FASTA scores: E(): FT 2.3e-14, (42.4% identity in 125 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:P71665" FT /protein_id="CAB02178.1" FT /translation="MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGG FT MRTAERREVWRLLASFRVQPATEVIARRAGDMMRRYRRSHNRIGLGDYLIAATADVQDL FT QLATLNVWHFPMFEQLKPPFAVPGHRPRA" FT CDS complement(191467..191724) FT /transl_table=11 FT /locus_tag="Rv1398c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1398c, (MTCY21B4.15c), len: 85 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT proteins Rv2547|MTCY159.09C (85 aa), FASTA scores: E(): FT 0.0035, (37.1% identity in 62 aa overlap); Rv0581, Rv2871, FT Rv1241, etc." FT /db_xref="GOA:P64835" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/Swiss-Prot:P64835" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02179.1" FT /translation="MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDD FT LASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQVWRATS" FT CDS complement(191807..192766) FT /transl_table=11 FT /gene="lipH" FT /locus_tag="Rv1399c" FT /product="PROBABLE LIPASE LIPH" FT /function="UNKNOWN, BUT SUPPOSED INVOLVED IN LIPID FT METABOLISM" FT /EC_number="3.1.-.-" FT /note="Rv1399c, (MTCY21B4.16c), len: 319 aa. Possible LipH, FT lipase (EC 3.1.-.-), most similar to G695278 lipase like FT enzyme from Ralstonia eutropha (364 aa), FASTA scores: opt: FT 648, E(): 4.4e-34, (37.3% identity in 327 aa ov erlap), FT similar to Mycobacterium tuberculosis hypothetical lipases FT e.g. Rv2284, Rv2485c, Rv1426c, etc." FT /db_xref="GOA:P71667" FT /db_xref="HSSP:1JJI" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:P71667" FT /protein_id="CAB02180.1" FT /translation="MTEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTP FT PELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDNLPVVVYYHGGGWSLGGLDTHDPVA FT RAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAGDSA FT GGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAW FT YVPGLDISDHTMLPTTLAPGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVE FT LSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA" FT CDS complement(192791..193753) FT /transl_table=11 FT /gene="lipI" FT /locus_tag="Rv1400c" FT /product="PROBABLE LIPASE LIPH" FT /function="UNKNOWN, BUT POSSIBLY INVOLVED IN LIPID FT METABOLISM" FT /EC_number="3.1.-.-" FT /note="Rv1400c, (MTCY21B4.17c), len: 320 aa. Possible lipI, FT lipase (EC 3.1.-.-), most similar to G695278 lipase like FT enzyme (364 aa), FASTA sscores: opt: 611, E(): 3.5e-30, FT (36.6% identity in 352 aa overlap); similar to M. FT tuberculosis hypothetical lipases e.g. Rv1399c|MTCY21B4.16c FT (58.1% identical in 315 aa overlap); Rv1426c, Rv2284, etc." FT /db_xref="GOA:P71668" FT /db_xref="HSSP:1JJI" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:P71668" FT /protein_id="CAB02181.1" FT /translation="MPSLDNTADEKPAIDPILLKVLDAVPFRLSIDDGIEAVRQRLRDL FT PRQPVHPELRVVDLAIDGPAGPIGTRIYWPPTCPDQAEAPVVLYFHGGGFVMGDLDTHD FT GTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAATRWVAEHGRQVGADLGRIAVAG FT DSAGGTIAAVIAQRARDMGGPPIVFQLLWYPSTLWDQSLPSLAENADAPILDVKAIAAF FT SRWYAGEIDLHNPPAPMAPGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPV FT EVHNAQTLVHGYVGYAGVVPAATEATNRGLVALRVVLHG" FT CDS 193887..194489 FT /transl_table=11 FT /locus_tag="Rv1401" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1401, (MTCY21B4.18), len: 200 aa. Possible FT membrane protein." FT /db_xref="GOA:P64837" FT /db_xref="InterPro:IPR012506" FT /db_xref="UniProtKB/Swiss-Prot:P64837" FT /protein_id="CAB02195.1" FT /translation="MLQPAFKASMAVLLAAAAVAHPIGRERRWLVPALLLSATGDWLLA FT IPWWTWAFVFGLGAFLLAHLCFIGALLPLARQAAPSRGRVAAVVAMCVASAGLLVWFWP FT HLGKDNLTIPVTVYIVALSAMVCTALLARLPTIWTAVGAVCFAASDSMIGIGRFILGNE FT ALAVPIWWSYAAAEILITAGFFFGREVPDNAAAPTDS" FT CDS 194570..196537 FT /transl_table=11 FT /gene="priA" FT /locus_tag="Rv1402" FT /product="PUTATIVE PRIMOSOMAL PROTEIN N' PRIA (Replication FT factor Y)" FT /function="RECOGNIZES A SPECIFIC HAIRPIN SEQUENCE ON PHIX FT SSDNA; THIS STRUCTURE IS THEN RECOGNIZED AND BOUND BY FT PROTEINS PRIB AND PRIC. FORMATION OF THE PRIMOSOME PROCEEDS FT WITH THE SUBSEQUENT ACTIONS OF DNAB, DNAC, DNAT AND FT PRIMASE. PRIA THEN FUNCTIONS AS A HELICASE WITHIN THE FT PRIMOSOME" FT /note="Rv1402, (MTCY21B4.19), len: 655 aa. Putative priA, FT primosomal protein N'. Similar to e.g. PRIA_ECOLI|P17888 FT primosomal protein N' (replication factor Y) (732 aa), FT FASTA scores, opt: 386, E(): 1.3e-16, (27.6% identity in FT 711 aa overlap). Compared to other bacterial priA, it has a FT very divergent helicase domain. BELONGS TO THE HELICASE FT FAMILY. PRIA SUBFAMILY." FT /db_xref="GOA:P0A5A5" FT /db_xref="UniProtKB/Swiss-Prot:P0A5A5" FT /protein_id="CAB02196.1" FT /translation="MLSVPHLDRDFDYLVPAEHSDDAQPGVRVRVRFHGRLVDGFVLER FT RSDSDHHGKLGWLDRVVSPEPVLTTEIRRLVDAVAARYAGTRQDVLRLAVPARHARVER FT EITTAPGRPVVAPVDPSGWAAYGRGRQFLAALADSRAARAVWQALPGELWADRFAEAAA FT QTVRAGRTVLAIVPDQRDLDTLWQAATALVDEHSVVALSAGLGPEARYRRWLAALRGSA FT RLVIGTRSAVFAPLSELGLVMVWADADDSLAEPRAPYPHAREVAMLRAHQARCAALIGG FT YARTAEAHALVRSGWAHDVVAPRPEVRARSPRVVALDDSGYDDARDPAARTARLPSIAL FT RAARSALQSGAPVLVQVPRRGYIPSLACGRCRAIARCRSCTGPLSLQGAGSPGAVCRWC FT GRVDPTLRCVRCGSDVVRAVVVGARRTAEELGRAFPGTAVITSAGDTLVPQLDAGPALV FT VATPGAEPRAPGGYGAALLLDSWALLGRQDLRAAEDALWRWMTAAALVRPRGAGGVVTV FT VAESSIPTVQSLIRWDPVGHAEAELAARTEVGLPPSVHIAALDGPAGTVTALLEAARLP FT DPDRLQADLLGPVDLPPGVRRPAGIPADAPVIRMLLRVCREQGLELAASLRRGIGVLSA FT RQTRQTRSLVRVQIDPLHIG" FT CDS complement(196555..197379) FT /transl_table=11 FT /locus_tag="Rv1403c" FT /product="PUTATIVE METHYLTRANSFERASE" FT /function="CAUSES METHYLATION" FT /EC_number="2.1.1.-" FT /note="Rv1403c, (MTCY21B4.20c), len: 274 aa. Putative FT methyltransferase (EC 2.1.1.-), similar to FT PMTA_RHOSH|Q05197 phosphatidylethanolamine FT m-methyltransferase (203 aa), FASTA scores: opt: 217, E(): FT 1.1e-07, (37.1% identity in 105 aa overlap); similar to FT Rv1405c|MTCY21B4.22c (59.3% identity in 273 aa overlap) and FT to Rv1523, Rv2952, etc." FT /db_xref="GOA:P64839" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P64839" FT /protein_id="CAB02182.1" FT /translation="MTVYTPTSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVSTS FT GIRRGDRVLDVAAGSGNVSIPAAMAGAHVTASDLTPELLRRAQARAAAAGLELGWREAN FT AEALPFSAGEFDAVLSTIGVMFAPRHQRTADELARVCRRGGKISTLNWTPEGFYGKLLS FT TIRPYRPTLPAGAPHEVWWGSEDYVSGLFRDHVSDIRTRRGSLTVDRFGCPDECRDYFK FT NFYGPAINAYRSIADSPECVATLDAEITELCREYLCDGVMQWEYLIFTARKC" FT CDS 197548..198030 FT /transl_table=11 FT /locus_tag="Rv1404" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1404, (MTCY21B4.21), len: 160 aa. Probable FT transcriptional regulatory protein, some similarity to FT MARR_ECOLI|P27245 multiple antibiotic resistance protein FT from Escherichia coli (125 aa), FASTA scores: opt: 136, FT E(): 0.004, (35.1% identity in 74 aa overlap)." FT /db_xref="GOA:P71672" FT /db_xref="InterPro:IPR000835" FT /db_xref="PDB:2NYX" FT /db_xref="UniProtKB/TrEMBL:P71672" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02183.1" FT /translation="MMPTEYPATAEESVDVITDALLTASRLLVAISAHSIAQVDENITI FT PQFRTLVILSNHGPINLATLATLLGVQPSATGRMVDRLVGAELIDRLPHPTSRRELLAA FT LTKRGRDVVRQVTEHRRTEIARIVEQMAPAERHGLVRALTAFTEAGGEPDARYEIE" FT CDS complement(198102..198926) FT /transl_table=11 FT /locus_tag="Rv1405c" FT /product="PUTATIVE METHYLTRANSFERASE" FT /function="CAUSES METHYLATION" FT /EC_number="2.1.1.-" FT /note="Rv1405c, (MTCY21B4.22c), len: 274 aa. Putative FT methyltransferase (EC 2.1.1.-), most similar to FT PMTA_RHOSH|Q05197 phosphatidylethanolamine FT m-methyltransferase (203 aa), FASTA scores: opt: 219, E(): FT 2.6e-07, (29.9% identity in 144 aa overlap); similar to FT Rv1403c|MTCY21B4.20c (59.3% identity in 273 aa overlap), FT Rv1523, Rv2952, etc." FT /db_xref="GOA:P64841" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P64841" FT /protein_id="CAB02184.1" FT /translation="MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAAA FT GIGPGVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQQGLTLQYQEAN FT AQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISWTCEGFFGRMLA FT TIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFDTAQAVHDYFK FT NNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDGVMEWEYLLLTAEKR" FT CDS 199123..200061 FT /transl_table=11 FT /gene="fmt" FT /locus_tag="Rv1406" FT /product="PROBABLE METHIONYL-TRNA FORMYLTRANSFERASE FMT" FT /function="MODIFY THE FREE AMINO GROUP OF THE AMINOACYL FT MOIETY OF METHIONYL-TRNA(FMET). THE FORMYL GROUP APPEARS TO FT PLAY A DUAL ROLE IN THE INITIATOR IDENTITY OF FT N-FORMYLMETHIONYL-TRNA BY:(I) PROMOTING ITS RECOGNITION BY FT IF2 AND (II) IMPAIRING ITS BINDING TO EFTU-GTP. [CATALYTIC FT ACTIVITY : 10-FORMYLTETRAHYDROFOLATE + L-METHIONYL-TRNA + FT H(2)O = TETRAHYDROFOLATE + N-FORMYLMETHIONYL-TRNA]" FT /EC_number="2.1.2.9" FT /note="Rv1406, (MTCY21B4.23), len: 312 aa. Probable fmt, FT methionyl-tRNA formyltransferase (EC 2.1.2.9), similar to FT many e.g. FMT_ECOLI|P23882 Escherichia coli (314 aa), FASTA FT scores: opt: 616, E(): 6.7e-31, (39.3% identity in 303 aa FT overlap). BELONGS TO THE FMT FAMILY." FT /db_xref="GOA:P64134" FT /db_xref="HSSP:1FMT" FT /db_xref="InterPro:IPR015518" FT /db_xref="UniProtKB/Swiss-Prot:P64134" FT /protein_id="CAB02185.1" FT /translation="MRLVFAGTPEPALASLRRLIESPSHDVIAVLTRPDAASGRRGKPQ FT PSPVAREAAERGIPVLRPSRPNSAEFVAELSDLAPECCAVVAYGALLGGPLLAVPPHGW FT VNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPIYGVVTEVIQPTDTAG FT DLLKRLAVSGAALLSTTLDGIADQRLTPRPQPADGVSVAPKITVANARVRWDLPAAVVE FT RRIRAVTPNPGAWTLIGDLRVKLGPVHLDAAHRPSKPLPPGGIHVERTSVWIGTGSEPV FT RLGQIQPPGKKLMNAADWARGARLDLAARAT" FT CDS 200058..201431 FT /transl_table=11 FT /gene="fmu" FT /locus_tag="Rv1407" FT /product="PROBABLE FMU PROTEIN (SUN PROTEIN)" FT /function="UNKNOWN" FT /note="Rv1407, (MTCY21B4.24), len: 457 aa. Probable fmu FT protein, similar to SUN_ECOLI|P36929 sun protein (fmu FT protein) from Escherichia coli (429 aa), FASTA scores: E(): FT 2.5e-20, (30.6% identity in 451 aa overlap)." FT /db_xref="GOA:P71675" FT /db_xref="InterPro:IPR006027" FT /db_xref="UniProtKB/Swiss-Prot:P71675" FT /protein_id="CAB02186.1" FT /translation="MTPRSRGPRRRPLDPARRAAFETLRAVSARDAYANLVLPALLAQR FT GIGGRDAAFATELTYGTCRARGLLDAVIGAAAERSPQAIDPVLLDLLRLGTYQLLRTRV FT DAHAAVSTTVEQAGIEFDSARAGFVNGVLRTIAGRDERSWVGELAPDAQNDPIGHAAFV FT HAHPRWIAQAFADALGAAVGELEAVLASDDERPAVHLAARPGVLTAGELARAVRGTVGR FT YSPFAVYLPRGDPGRLAPVRDGQALVQDEGSQLVARALTLAPVDGDTGRWLDLCAGPGG FT KTALLAGLGLQCAARVTAVEPSPHRADLVAQNTRGLPVELLRVDGRHTDLDPGFDRVLV FT DAPCTGLGALRRRPEARWRRQPADVAALAKLQRELLSAAIALTRPGGVVLYATCSPHLA FT ETVGAVADALRRHPVHALDTRPLFEPVIAGLGEGPHVQLWPHRHGTDAMFAAALRRLT" FT CDS 201456..202154 FT /transl_table=11 FT /gene="rpe" FT /locus_tag="Rv1408" FT /product="PROBABLE RIBULOSE-PHOSPHATE 3-EPIMERASE RPE (PPE) FT (R5P3E) (Pentose-5-phosphate 3-epimerase)" FT /function="INVOLVED IN THE CALVIN CYCLE [CATALYTIC ACTIVITY FT : D-RIBULOSE 5-PHOSPHATE = D-XYLULOSE 5- PHOSPHATE]" FT /EC_number="5.1.3.1" FT /note="Rv1408, (MTCY21B4.25), len: 232 aa. Probable rpe, FT ribulose-phosphate 3-epimerase (EC 5.1.3.1), similar to FT many e.g. CXEC_ALCEU|P40117 (241 aa), FASTA scores: opt: FT 638, E(): 1.5e-34, (48.3% identity in 234 aa overlap); and FT RPE_ECOLI|P32661 ribulose-phosphate 3-epimerase (225 aa), FT FASTA scores: E(): 0, (46.2% identity in 221 aa overlap). FT Contains PS01085 Ribulose-phosphate 3-epimerase family FT signature 1. BELONGS TO THE RIBULOSE-PHOSPHATE 3-EPIMERASE FT FAMILY." FT /db_xref="GOA:P65760" FT /db_xref="HSSP:1H1Y" FT /db_xref="InterPro:IPR000056" FT /db_xref="UniProtKB/Swiss-Prot:P65760" FT /protein_id="CAB02187.1" FT /translation="MSLMAGSTGGPLIAPSILAADFARLADEAAAVNGADWLHVDVMDG FT HFVPNLTIGLPVVESLLAVTDIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPV FT GVARDIRAAGAKAGISVKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLSKVR FT AVRKMVDAGELTILVEIDGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAALRRQ FT AGAASLHLSL" FT misc_feature 201567..201611 FT /note="PS01085 Ribulose-phosphate 3-epimerase family FT signature 1" FT misc_feature 201867..201941 FT /note="PS01086 Ribulose-phosphate 3-epimerase family FT signature 2" FT CDS 202151..203170 FT /transl_table=11 FT /gene="ribG" FT /locus_tag="Rv1409" FT /standard_name="ribD" FT /product="PROBABLE BIFUNCTIONAL riboflavin biosynthesis FT protein RIBG : Diaminohydroxyphosphoribosylaminopyrimidine FT deaminase (Riboflavin-specific deaminase) + FT 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP FT reductase)" FT /function="INVOLVED IN RIBOFLAVIN BIOSYNTHESIS (AT THE FT SECOND AND THIRD STEPS). CONVERTS FT 2,5-DIAMINO-6-(RIBOSYLAMINO)-4(3H)-PYRIMIDINONE FT 5'-PHOSPHATE INTO FT 5-AMINO-6-(RIBOSYLAMINO)-2,4(1H,3H)-PYRIMIDINEDIONE FT 5'-PHOSPHATE [CATALYTIC ACTIVITY 1: FT 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE + FT H(2)O = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NH(3)] FT [CATALYTIC ACTIVITY 2: FT 5-AMINO-6-(5-PHOSPHORIBITYLAMINO)URACIL + NADP(+) = FT 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NADPH]." FT /EC_number="3.5.4.26" FT /EC_number="1.1.1.193" FT /note="Rv1409, (MTCY21B4.26), len: 339 aa. Probable ribG FT (alternate gene name: ribD), bifunctional riboflavin FT biosynthesis protein, including FT diaminohydroxyphosphoribosylaminopyrimidine deaminase and FT 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC FT 3.5.4.26 and 1.1.1.193), similar to many e.g. FT RIBD_ECOLI|P25539 riboflavin-specific deaminase from FT Escherichia coli (367 aa), FASTA scores: E(): 0, (39.8% FT identity in 364 aa overlap); etc. Contains PS00903 Cytidine FT and deoxycytidylate deaminases zinc-binding region FT signature. IN THE N-TERMINAL SECTION; BELONGS TO THE FT CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. IN THE FT C-TERMINAL SECTION; BELONGS TO THE HTP REDUCTASE FAMILY." FT /db_xref="GOA:P71677" FT /db_xref="InterPro:IPR011549" FT /db_xref="UniProtKB/Swiss-Prot:P71677" FT /protein_id="CAB02188.1" FT /translation="MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIV FT GAGGTEPAGGDHAEVVALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVV FT YAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATS FT IDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAP FT QQPLRVVVGKRDIPPEARVLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAF FT LRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR" FT misc_feature 202319..202435 FT /note="PS00903 Cytidine and deoxycytidylate deaminases FT zinc-binding region signature" FT CDS complement(203167..204723) FT /transl_table=11 FT /locus_tag="Rv1410c" FT /standard_name="P55" FT /product="AMINOGLYCOSIDES/TETRACYCLINE-TRANSPORT INTEGRAL FT MEMBRANE PROTEIN" FT /function="INVOLVED IN TRANSPORT OF AMINOGLYCOSIDES AND FT TETRACYCLINE ACROSS THE MEMBRANE (EXPORT): DRUG RESISTANCE FT BY AN EXPORT MECHANISM (CONFERES RESISTANCE TO TOXIC FT COMPOUNDS BY REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR FT THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv1410c, (MTCY21B4.27c), len: 518 aa. FT Aminoglycoside/tetracycline-transport integral membrane FT protein (see citation below), member of major facilitator FT superfamily (MFS), similar to others e.g. AC22_STRCO|P46105 FT probable actinorhodin transporter from Streptomyces FT coelicolor (578 aa), FASTA scores: opt: 442, E(): 4.9e-21, FT (28.5% identity in 466 aa overlap); etc. Contains PS00216 FT Sugar transport proteins signature 1. Could be termed P55. FT Note that the Rv1410c-Rv1411c operon seems transcribed from FT two promoters in Mycobacterium bovis BCG (see Bigi et al., FT 2000)." FT /db_xref="GOA:P71678" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:P71678" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02189.1" FT /translation="MRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMNSVGIPINQLH FT RITWIVTMYLLGYIAAMPLLGRASDRFGRKLMLQVSLAGFIIGSVVTALAGHFGDFHML FT IAGRTIQGVASGALLPITLALGADLWSQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWL FT LHDWRDVFWINVPLTAIAMVMIHFSLPSHDRSTEPERVDLVGGLLLALALGLAVIGLYN FT PNPDGKHVLPDYGAPLLVGALVAAVAFFGWERFARTRLIDPAGVHFRPFLSALGASVAA FT GAALMVTLVDVELFGQGVLQMDQAQAAGMLLWFLIALPIGAVTGGWIATRAGDRAVAFA FT GLLIAAYGYWLISHWPVDLLADRHNILGLFTVPAMHTDLVVAGLGLGLVIGPLSSATLR FT VVPSAQHGIASAAVVVARMTGMLIGVAALSAWGLYRFNQILAGLSAAIPPNASLLERAA FT AIGARYQQAFALMYGEIFTITAIVCVFGAVLGLLISGRKEHADEPEVQEQPTLAPQVEP FT L" FT misc_feature complement(204481..204531) FT /note="PS00216 Sugar transport proteins signature 1" FT CDS complement(204729..205439) FT /transl_table=11 FT /gene="lprG" FT /locus_tag="Rv1411c" FT /standard_name="P27" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRG" FT /function="UNKNOWN" FT /note="Rv1411c, (MTCY21B4.28c), len: 236. Probable lprG FT (alternate gene name: P27), conserved lipoprotein, similar FT to Mycobacterium tuberculosis hypothetical lipoproteins FT e.g. Rv1270c|MTCY50.12 (35.1% identity in 245 aa overlap); FT Rv1368, Rv2945c. Contains N-terminal signal sequence and FT appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013). Note that the Rv1410c-Rv1411c FT operon seems transcribed from two promoters in FT Mycobacterium bovis BCG (see Bigi et al., 2000)." FT /db_xref="GOA:P0A5I8" FT /db_xref="InterPro:IPR009830" FT /db_xref="UniProtKB/Swiss-Prot:P0A5I8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02197.1" FT /translation="MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLV FT EEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADF FT VVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQ FT NTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLS FT KWGEKVQVTKPPVS" FT CDS 205524..206129 FT /transl_table=11 FT /gene="ribC" FT /locus_tag="Rv1412" FT /product="PROBABLE RIBOFLAVIN SYNTHASE ALPHA CHAIN RIBC FT (RIBE)" FT /function="INVOLVED IN RIBOFLAVIN SYNTHESIS. RIBOFLAVIN FT SYNTHASE IS A BIFUNCTIONAL ENZYME COMPLEX CATALYZING THE FT FORMATION OF RIBOFLAVIN FROM 5-AMINO-6-(1'-D)- FT RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE AND FT L-3,4-DIHYDROHY-2- BUTANONE-4-PHOSPHATE VIA FT 6,7-DIMETHYL-8-LUMAZINE. THE ALPHA SUBUNIT CATALYZES THE FT DISMUTATION OF 6,7-DIMETHYL-8-LUMAZINE TO RIBOFLAVIN AND FT 5-AMINO-6-(1'-D)-RIBITYL-AMINO-2,4(1H,3H)- FT PYRIMIDINEDIONE." FT /EC_number="2.5.1.9" FT /note="Rv1412, (MTCY21B4.29), len: 201 aa. Probable ribC FT (ribE), Riboflavin synthase alpha chain (EC 2.5.1.9), FT strong similarity to e.g. RISA_ACTPL|P50854 (215 aa), FASTA FT scores: opt: 586, E(): 1.8e-33, (50.8% identity in 197 aa FT overlap). Contains 2 x PS00693 Riboflavin synthase alpha FT chain family signature." FT /db_xref="GOA:P65327" FT /db_xref="HSSP:1I8D" FT /db_xref="InterPro:IPR001783" FT /db_xref="UniProtKB/Swiss-Prot:P65327" FT /protein_id="CAB02162.1" FT /translation="MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNG FT VCLTVVDVLPDGQFTADVMAETLNRSNLGELRPGSRVNLERAAALGSRLGGHIVQGHVD FT ATGEIVARCPSEHWEVVRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFEVSL FT IPTTRELTTLGSAAVGTRVNLEVDVVAKYVERLMRSAG" FT misc_feature 205740..205778 FT /note="PS00693 Riboflavin synthase alpha chain family FT signature" FT misc_feature 206040..206078 FT /note="PS00693 Riboflavin synthase alpha chain family FT signature" FT CDS 206343..206858 FT /transl_table=11 FT /locus_tag="Rv1413" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1413, (MTCY21B4.30), len: 171 aa. Conserved FT hypothetical protein, similar to part of FT AB010956|AB010956_1 metal-activated pyridoxal enzyme from FT Arthrobacter sp. (379 aa), FASTA scores: opt: 187, E(): FT 0.00026, (29.0% identity in 162 aa overlap)." FT /db_xref="InterPro:IPR001608" FT /db_xref="UniProtKB/Swiss-Prot:P64843" FT /protein_id="CAB02198.1" FT /translation="MATIGEVEVFVDHGADDVFITYPLWIGTRQADRLRQLADRARIAV FT GAGTAEGASNTGARLADAAGAIDVLIEIDSGHHRSGVRAEQVLEVAHAVGEAGLHLVGV FT FTFPGHSYAPGKPGEAGEQERRALNDAANALVAVGFPISCRSGGSTPTALLTAADGASE FT TSRRLCAR" FT CDS 206848..207249 FT /transl_table=11 FT /locus_tag="Rv1414" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1414, (MTCY21B4.31), len: 133 aa. Conserved FT hypothetical protein, similar to C-terminal part of FT AB010956|AB010956_1 novel metal-activated pyridoxal enzyme FT from Arthrobacter sp. (379 aa), FASTA scores: opt: 163, FT E(): 0.00063, (32.1% identity in 112 aa overlap). Rv1413 is FT similar to N-terminal part of same enzyme suggesting FT possible frameshift. Sequence has been checked and no FT errors found, it is identical in Mycobacterium bovis strain FT AF2122/97 and in Mycobacterium tuberculosis CDC1551." FT /db_xref="UniProtKB/Swiss-Prot:P64845" FT /protein_id="CAB02163.1" FT /translation="MLGDAQQLELGRCAPADIALTVAATVVSRQDCRSGLRRIVLDCGS FT KILGSDRPAWATGFGRLIDHADARIAALSEHHATVVWPDDAPLPPVGTRLRVIPNHVCL FT TTNLVDDVAVVRDATLIDRWKVAARGKNH" FT CDS 207354..208631 FT /transl_table=11 FT /gene="ribA2" FT /locus_tag="Rv1415" FT /product="PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : FT GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone FT 4-phosphate synthase (DHBP synthase)" FT /function="INVOLVED IN RIBOFLAVIN BIOSYNTHESIS [CATALYTIC FT ACTIVITY : GTP + 3 H(2)O = FORMATE + FT 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE + FT DIPHOSPHATE]." FT /EC_number="3.5.4.25" FT /note="Rv1415, (MTCY21B4.33), len: 428 aa. Probable ribA2, FT Riboflavin biosynthesis protein (EC 3.5.4.25), similar to FT many e.g. GCH2_BACSU|P17620 Bacillus subtilis (398 aa), FT FASTA scores: opt: 1388, E(): 0, (55.4% identity in 399 aa FT overlap). Also similar to second Mycobacterium tuberculosis FT gtp cyclohydrolase Rv1940|ribA1 (353 aa). IN THE N-TERMINAL FT SECTION; BELONGS TO THE DHBP SYNTHASE FAMILY. IN THE FT C-TERMINAL SECTION; BELONGS TO THE GTP CYCLOHYDROLASE II FT FAMILY." FT /db_xref="GOA:P0A5V0" FT /db_xref="HSSP:1K49" FT /db_xref="InterPro:IPR016299" FT /db_xref="UniProtKB/Swiss-Prot:P0A5V0" FT /protein_id="CAB02199.1" FT /translation="MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEM FT VAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGISASD FT RATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAI FT CEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHG FT EFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQL FT DAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARD FT YGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRD FT KLGHDLAGLDDFHESVHLPGEFGGAL" FT CDS 208646..209110 FT /transl_table=11 FT /gene="ribH" FT /locus_tag="Rv1416" FT /product="PROBABLE RIBOFLAVIN SYNTHASE BETA CHAIN RIBH FT (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) FT (Lumazine synthase)" FT /function="RIBOFLAVIN SYNTHASE IS A BIFUNCTIONAL ENZYME FT COMPLEX INVOLVED IN RIBOFLAVIN SYNTHESIS. RIBOFLAVIN FT SYNTHASE CATALYZES THE FORMATION OF RIBOFLAVIN FROM FT 5-AMINO-6-(1'-D)- RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE FT AND L-3,4-DIHYDROHY-2- BUTANONE-4-PHOSPHATE VIA FT 6,7-DIMETHYL-8-LUMAZINE. THE BETA SUBUNIT CATALYZES THE FT CONDENSATION OF 5-AMINO-6-(1'-D)-RIBITYL- FT AMINO-2,4(1H,3H)-PYRIMIDINEDIONE WITH FT L-3,4-DIHYDROHY-2-BUTANONE- 4-PHOSPHATE YIELDING FT 6,7-DIMETHYL-8-LUMAZINE." FT /EC_number="2.5.1.9" FT /note="Rv1416, (MTCY21B4.34), len: 154 aa. Probable ribH, FT riboflavin synthase beta chain (EC 2.5.1.9), similar to FT many e.g. RISB_ECOLI|P25540 Escherichia coli (156 aa), FT FASTA scores: opt: 330, E(): 1.8e-15, (44.1% identity in FT 145 aa overlap). Note alternative GTG start possible FT overlapping the stop codon of Rv1415|MTCY21B4.33. BELONGS FT TO THE DMRL SYNTHASE FAMILY." FT /db_xref="GOA:P66034" FT /db_xref="InterPro:IPR002180" FT /db_xref="PDB:2C94" FT /db_xref="UniProtKB/Swiss-Prot:P66034" FT /protein_id="CAB02164.1" FT /translation="MPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDP FT TVVRVLGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSST FT PIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLRELRAHS" FT CDS 209107..209571 FT /transl_table=11 FT /locus_tag="Rv1417" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1417, (MTCY21B4.35), len: 154 aa. Possible FT conserved membrane protein, similar to others e.g. FT AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA FT scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa FT overlap)." FT /db_xref="GOA:P64847" FT /db_xref="InterPro:IPR019692" FT /db_xref="UniProtKB/Swiss-Prot:P64847" FT /protein_id="CAB02165.1" FT /translation="MTAAPNDWDVVLRPHWTPLFAYAAAFLIAVAHVAGGLLLKVGSSG FT VVFQTADQVAMGALGLVLAGAVLLFARPRLRVGSAGLSVRNLLGDRIVGWSEVIGVSFP FT GGSRWARIDLADDEYIPVMAIQAVDKDRAVAAMDTVRSLLARYRPDLCAR" FT CDS 209596..210282 FT /transl_table=11 FT /gene="lprH" FT /locus_tag="Rv1418" FT /product="PROBABLE LIPOPROTEIN LPRH" FT /function="UNKNOWN" FT /note="Rv1418, (MTCY21B4.36), len: 228 aa. Probable lprH, FT lipoprotein. Contains N-terminal signal sequence and FT appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013)." FT /db_xref="GOA:P65316" FT /db_xref="UniProtKB/Swiss-Prot:P65316" FT /protein_id="CAB02166.1" FT /translation="MACLGRPGCRGWAGASLVLVVVLALAACTESVAGRAMRATDRSSG FT LPTSAKPARARDLLLQDGDRAPFGQVTQSRVGDSYFTSAVPPECSAALLFKGSPLRPDG FT SSDHAEAAYNVTGPLPYAESVDVYTNVLNVHDVVWNGFRDVSHCRGDAVGVSRAGRSTP FT MRLRYFATLSDGVLVWTMSNPRWTCDYGLAVVPHAVLVLSACGFKPGFPMAEWASKRRA FT QLDSQV" FT CDS 210462..210935 FT /transl_table=11 FT /locus_tag="Rv1419" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1419, (MTCY21B4.37), len: 157 aa. Hypothetical FT unknown protein." FT /db_xref="GOA:P64849" FT /db_xref="HSSP:1KNM" FT /db_xref="InterPro:IPR000772" FT /db_xref="UniProtKB/Swiss-Prot:P64849" FT /protein_id="CAB02167.1" FT /translation="MGELRLVGGVLRVLVVVGAVFDVAVLNAGAASADGPVQLKSRLGD FT VCLDAPSGSWFSPLVINPCNGTDFQRWNLTDDRQVESVAFPGECVNIGNALWARLQPCV FT NWISQHWTVQPDGLVKSDLDACLTVLGGPDPGTWVSTRWCDPNAPDQQWDSVP" FT CDS 210999..212939 FT /transl_table=11 FT /gene="uvrC" FT /locus_tag="Rv1420" FT /product="PROBABLE EXCINUCLEASE ABC (SUBUNIT C-NUCLEASE) FT UVRC" FT /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC FT EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE FT EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS FT PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). ATTACHES FT TO THE UVRA-UVRB COMPLEX, DISPLACING UVRA, AND THE DAMAGED FT DNA STRAND IS NICKED ON BOTH SIDES OF THE DAMAGED SITE" FT /note="Rv1420, (MTCY21B4.38), len: 646 aa. Probable uvrC, FT excinuclease ABC, subunit C; nuclease (see citations FT below), similar to many e.g. UVRC_PSEFL|P32966 Pseudomonas FT fluorescens (607 aa), fasta scores: opt: 738, E(): 8.4e-39, FT (36.6% identity in 629 aa overlap). BELONGS TO THE UVRC FT FAMILY." FT /db_xref="GOA:P67426" FT /db_xref="InterPro:IPR000305" FT /db_xref="UniProtKB/Swiss-Prot:P67426" FT /protein_id="CAB02168.1" FT /translation="MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTS FT YFADVASLAPRTRQLVTTAAKVEWTVVGTEVEALQLEYTWIKEFDPRFNVRYRDDKSYP FT VLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKR FT HRQIDRPCLLGYIDKCSAPCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAA FT EQLDFERAARLRDDLSALKRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRV FT RGQRGWIVEKPGEPGDSGIQLVEQFLTQFYGDQAALDDAADESANPVPREVLVPCLPSN FT AEELASWLSGLRGSRVVLRVPRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAAL FT QSIQDSLGLADAPLRIECVDVSHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGR FT SDDVACIAEVTRRRFLRHLRDQSDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAV FT IDELGVTDVAVIGLAKRLEEVWVPSEPDPIIMPRNSEGLYLLQRVRDEAHRFAITYHRS FT KRSTRMTASALDSVPGLGEHRRKALVTHFGSIARLKEATVDEITAVPGIGVATATAVHD FT ALRPDSSGAAR" FT CDS 212936..213841 FT /transl_table=11 FT /locus_tag="Rv1421" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1421, (MTCY21B4.39), len: 301 aa. Conserved FT hypothetical protein, similar to many hypothetical proteins FT e.g. YHBJ_ECOLI|P33995 hypothetical 32.5 kd protein from FT Escherichia coli (284 aa), FASTA scores: opt: 648, E(): FT 6.3e-36, (38.7% identity in 282aa overlap)." FT /db_xref="GOA:P67106" FT /db_xref="InterPro:IPR005337" FT /db_xref="UniProtKB/Swiss-Prot:P67106" FT /protein_id="CAB02169.1" FT /translation="MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVA FT DNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFM FT EASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLR FT DSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPA FT VRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMG FT LLRSDQQLSVRALHRDLGRE" FT CDS 213838..214866 FT /transl_table=11 FT /locus_tag="Rv1422" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1422, (MTCY21B4.40), len: 342 aa. Conserved FT hypothetical protein, similar to many hypothetical proteins FT e.g. YAMB_THETU|P38541 Thermoanaerobacterium FT thermosulfurigenes (323 aa), FASTA scores: opt: 519, E(): FT 1.6e-25, (33.1% identity in 320 aa overlap); and FT AF106003|AF106003_3 Streptomyces coelicolor (363 aa), FASTA FT scores: opt: 1047, E(): 0, (54.5% identity in 308 aa FT overlap)." FT /db_xref="InterPro:IPR010119" FT /db_xref="UniProtKB/Swiss-Prot:P71691" FT /protein_id="CAB02170.1" FT /translation="MTDGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRLR FT SELDVVPPGDLRMALAALASDSPHGRLWATILQHRFGGSGALAGHPIGNLMLAGLSEVL FT ADPVAALDELGRILGVKGRVLPMCPVALQIEADVSGLEADPRMFRLIRGQVAIATTPGK FT VRRVRLLPTDPPATRQAVDAIMAADLVVLGPGSWFTSVIPHVLVPGLAAALRATSARRA FT LVLNLVAEPGETAGFSVERHLHVLAQHAPGFTVHDIIIDAERVPSEREREQLRRTATML FT QAEVHFADVARPGTPLHDPGKLAAVLDGVCARDVGASEPPVAATQEIPIDGGRPRGDDA FT WR" FT CDS 214863..215840 FT /transl_table=11 FT /gene="whiA" FT /locus_tag="Rv1423" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIA" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1423, (MTCY21B4.41-MTCY493.31c), len: 325 aa. FT Putative whiA, transcriptional regulator, probably FT equivalent to AL035591|SCC54.10 whiA protein from FT Streptomyces coelicolor (328 aa), FASTA scores: opt: 1505, FT E(): 0, (70.4% identity in 324 aa overlap). Also some FT similarity to O06975|YVCL hypothetical protein from FT Bacillus subtilis (316 aa), FASTA scores: E(): 1.8e-0 8, FT (25.7% identity in 304 aa overlap)." FT /db_xref="InterPro:IPR018478" FT /db_xref="UniProtKB/Swiss-Prot:P71692" FT /protein_id="CAB02171.1" FT /translation="MTTDVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVEA FT ELDLGSIARRLRKEIFELYGYTAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLLDM FT RGRPVRGLPAQVVGGSIDDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGA FT ARRLGVGAKAREVRGADRVVVRDGEAIGALLTRMGAQDTRLVWEERRLRREVRATANRL FT ANFDDANLRRSARAAVAAAARVERALEILGDTVPEHLASAGKLRVEHRQASLEELGRLA FT DPPMTKDAVAGRIRRLLSMADRKAKVDGIPDTESVVTPDLLEDA" FT CDS complement(215850..216611) FT /transl_table=11 FT /locus_tag="Rv1424c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1424c, (MTCY21B4.42c,MTCY493.30), len: 253 aa. FT Possible membrane protein, contains PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp signature." FT /db_xref="UniProtKB/Swiss-Prot:P64851" FT /protein_id="CAB09246.1" FT /translation="MTVVPGAPSRPASAVSRPSYRQCVQASAQTSARRYSFPSYRRPPA FT EKLVFPVLLGILTLLLSACQTASASGYNEPRGYDRATLKLVFSMDLGMCLNRFTYDSKL FT APSRPQVVACDSREARIRNDGFHANAPSCMRIDYELITQNHRAYYCLKYLVRVGYCYPA FT VTTPGKPPSVLLYAPSACDESLPSPRVATALVPGTRSANREFSRFVVTEIKSLGAGGRC FT DSASVSLQPPEEIEGPAIPPASSQLVCVAPK" FT misc_feature complement(216360..216446) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp signature" FT CDS 216615..217994 FT /transl_table=11 FT /locus_tag="Rv1425" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1425, (MTCY21B4.43,MTCY493.29c), len: 459 aa. FT Conserved hypothetical protein, similar to many M. FT tuberculosis hypothetical proteins e.g. Rv3740c, Rv3734c, FT Rv1760, etc." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/Swiss-Prot:P71694" FT /protein_id="CAB09245.1" FT /translation="MKRLSSVDAAFWSAETAGWHMHVGALAICDPSDAPEYSFQRLREL FT IIERLPEIPQLRWRVTGAPLGLDRPWFVEDEELDIDFHIRRIGVPAPGGRRELEELVGR FT LMSYKLDRSRPLWELWVIEGVEGGRIATLTKMHHAIVDGVSGAGLGEILLDITPEPRPP FT QQETVGFVGFQIPGLERRAIGALINVGIMTPFRIVRLLEQTVRQQIAALGVAGKPARYF FT EAPKTRFNAPVSPHRRVTGTRVELARAKAVKDAFGVKLNDVVLALVAGAARQYLQKRDE FT LPAKPLIAQIPVSTRSEETKADVGNQVSSMTASLATHIEDPAKRLAAIHESTLSAKEMA FT KAPSAHQIMGLTETTPPGLLQLAARAYTASGLSHNLAPINLVVSNVPGPPFPLYMAGAR FT LDSLVPLGPPVMDVALNITCFSYQDYLDFGLVTTPEVANDIDEMADAIEPALAELERAA FT E" FT CDS complement(218016..219278) FT /transl_table=11 FT /gene="lipO" FT /locus_tag="Rv1426c" FT /product="PROBABLE ESTERASE LIPO" FT /function="UNKNOWN, BUT SUPPOSED INVOLVED IN LIPID FT METABOLISM" FT /EC_number="3.1.-.-" FT /note="Rv1426c, (MTCY493.28), len: 420 aa. Possible Lipo, FT esterase (EC 3.1.-.-), similar to several Mycobacterium FT tuberculosis hypothetical lipases and esterases e.g. FT Rv1399c, Rv2284, etc. Also similar in central region to FT AAAD_HUMAN|P22760 human arylacetamide deacetylase (398 aa), FT FASTA scores: opt:210, E(): 7.6e-07, (29.3% identity in 191 FT aa overlap)." FT /db_xref="GOA:O06832" FT /db_xref="InterPro:IPR002018" FT /db_xref="UniProtKB/TrEMBL:O06832" FT /protein_id="CAB09244.1" FT /translation="MRFRRMARPRPLTRAAVELLNAANGLRPLSGSGYSTVLAFWLGWP FT TSEVPGVYLGASVLDALRRGRRGDFGGLKGKAALALTAAAWVILAVIRYRGATTPGPVL FT EAGLTEQLGPDYAKELATLPTEPMRSRGRNLPLRTAMARRRYVETTNVVCYGPYGRANL FT ADIWRRRDLPRDAKAPVLVQVPGGAWVLGWRRPQAYPLMSHLAARGWVCVSLNYRVSPR FT HTWPDHIVDVKRALAWVKENIAAYGGDPNFVAISGGSAGGHLCALAALTPNDPRFQPGF FT EQVDTSVAAAVPVYGRYDWFTTDAPGRREFVGLLETFVVKRKFSTHRDIFVDASPIHHV FT RADAPPFFVLHGRHDSLIPVAEAHAFVEELRAVSKSPVAYADLPHAQHAFDVFGSPRAH FT HTAEAVARFLSWVYATNPPAT" FT CDS complement(219278..220885) FT /transl_table=11 FT /gene="fadD12" FT /locus_tag="Rv1427c" FT /product="POSSIBLE LONG-CHAIN-FATTY-ACID--CoA LIGASE FADD12 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID FT DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv1427c, (MTCY493.27), len: 535 aa. Possible fadD12, FT long-chain-fatty-acid-CoA synthetase (EC 6.2.1.-), similar FT to many e.g. NP_302632.1|NC_002677 acyl-CoA synthase from FT Mycobacterium leprae (548 aa); AAD01929.2|AF031419 putative FT long-chain-fatty-acid--CoA ligase from Pseudomonas putida FT (565 aa); NP_419782.1|NC_002696 putative FT long-chain-fatty-acid--CoA ligase from Caulobacter FT crescentus (530 aa); PC60_YEAST|P38137 yeast FT peroxisomal-coenzyme A synthetase (543 aa), FASTA scores: FT opt: 507, E(): 2.9e-25, (30.4% identity in 365 aa overlap). FT Also similar to many M. tuberculosis proteins e.g. FT MTCY06A4.14 (44.8% identity in 525 aa overlap). Contains FT PS00455 Putative AMP-binding domain signature. BELONGS TO FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:O06831" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:O06831" FT /protein_id="CAB09257.1" FT /translation="MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAGF FT AGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAGPPRVVGIMCRNHRGFVD FT ALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVYDEEFSATVDRALAEKPQATRI FT VAWTDEDHDLTVEKLVAAHAGRRPEHTGSHGKVILLTSGTTGTPKGARHSGGGIGTLKA FT ILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRRRFDPEATLDLIDRHHAT FT GLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPDVVIAFMDQFGDVIYNNYN FT ATEAGMIATATPADLRTAPDTAGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDG FT YTSGAAKDFHAGFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPD FT VAEAAVIGVDDQQYGQRLAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDIAVLDELP FT RGITGKILRTELQSRVGS" FT misc_feature complement(220262..220297) FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(220889..221716) FT /transl_table=11 FT /locus_tag="Rv1428c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1428c, (MTCY493.26), len: 275 aa. Conserved FT hypothetical protein, some similarity to hypothetical FT proteins from Mycobacterium tuberculosis e.g. FT Rv0502|YV29_MYCTU|Q11167 (358 aa), FASTA scores: opt: 355, FT E(): 5e-16, (32.6% identity in 273 aa overlap); and FT Rv1920." FT /db_xref="GOA:O06830" FT /db_xref="InterPro:IPR016676" FT /db_xref="UniProtKB/TrEMBL:O06830" FT /protein_id="CAB09256.1" FT /translation="MSETDSPGNGDDAGIGDIGKFDPGLTQRLISVLRPVLKTYHRSQV FT HGLDSFPPGGALVVANHSGGMFPMDVPVFSVDFYDKFGYDRPVYTLSHDILFMGLTGDL FT FRRTGYIRATRENAAKALRSGGVVVVFPGGDYDAYRPTFAENVIDFNGRKGYVSTAVEA FT GVPIVPAVSIGGQESQLYLSRGTWLARRLGLKRLLRSDILPISFGFPFGFSAAIPPNLP FT LPAKIVMQVLDPINLTKQFGEDPDVDAVDEHVRSVMQQALNDLAAKRRFPILG" FT CDS 221835..223103 FT /transl_table=11 FT /locus_tag="Rv1429" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1429, (MTCY493.25c), len: 422 aa. Conserved FT hypothetical protein, some similarity to transcriptional FT regulator proteins e.g. CDAR_ECOLI|P37047 Carbohydrate FT diacid regulator from Escherichia coli (391 aa), FASTA FT scores: opt: 210, E(): 3e-06, (27.7% identity in 296 aa FT overlap). Also similar to Mycobacterium tuberculosis FT hypothetical proteins Rv2370c, Rv1194c, Rv1453, Rv2242, and FT Rv1186c." FT /db_xref="UniProtKB/TrEMBL:O06829" FT /protein_id="CAB09255.1" FT /translation="MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMA FT DLWRASITENFVTAVHYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHA FT RFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQ FT QQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAG FT ELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVGD FT GLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGD FT LSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDA FT AFRVQMALEVCRWMAPAVLRAKQ" FT CDS 223343..224929 FT /transl_table=11 FT /gene="PE16" FT /locus_tag="Rv1430" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1430, (MTCY493.24c), len: 528 aa. Member of the FT Mycobacterium tuberculosis PE family of proteins (see FT citation below), e.g. Y0D4_MYCTU|Q50594 (55.9% identity in FT 127 aa overlap). The C-terminus shows similarity to FT Q49633|LEPB1170_F3_112 hypothetical Mycobacterium leprae FT protein (391 aa), FASTA scores: opt: 342, E(): 1.2e-13, FT (29.8% identity in 292 aa overlap). Possible TMhelix aa FT 500-522." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/TrEMBL:Q7D8G5" FT /protein_id="CAE55388.1" FT /translation="MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAAD FT EVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVDTAATG FT ASELGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWTGI FT PSLTYDQSVAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAPS FT PDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFADF FT PKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIVLPVSSPDTNTTYILLPNEDLPL FT LQPLRGIVPEPLLDLIEPDLRAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAA FT IGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVL FT PILVEGPGALVTADTHYLVDAIQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAA FT VAILTGQDFPV" FT CDS 225040..226809 FT /transl_table=11 FT /locus_tag="Rv1431" FT /product="CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1431, (MTCY493.23c), len: 589 aa. Conserved FT membrane protein, shows strong similarity to another M. FT tuberculosis hypothetical protein Rv1132|MTCY22G8.21 (48.2% FT identity in 585 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06827" FT /protein_id="CAB09253.1" FT /translation="MGFLKPDLPDVDHDTWLTQPRRTRLQVVTRDWVEHGFGTPYAVYL FT LYLTKIAVYVAAGAAIISLNPGLGGLSRIGDWWTQPIVYQKVIVFTLLFEVLGFGCGSG FT PLTGRFWPPIGGFLYWLRPNTIRLPAWPDKVPFTQGDTRTVVDVALYAIVLIGGVWALL FT SPGSPGPGGTPVTAAGDVGLINPVLVVPTIVALGVLGLRDKTIFLAARGEHYWLKLFVF FT FFPFTDQIAAFKIIMLCLWWGAATSKLNHHFPYVVAVMTSNNALLRSRVFNPIKHLLYR FT DHANDLRPSWLPKLMAHGGGTTAEFLVPGILVLVADGHPWRWFLIGFMVLFHLNILSNL FT PMGVPLEWNVFFIFSLCYLFGHYGAITATDLRSPLLLAIVIAVVAVVIMGNLLPEKISF FT LPAMRYYAGNWATSIWCFRGDAEATMETSVVKSSALVVNQLAKLYDGATAEIMTDKVAA FT FRAMHTHGRALNGLLPRALDDEAHYRIREGEIVAGPLVGWNFGEGHLHNEQLVAAVQRR FT CNFADGDLRVIILEGQPIHVQKQWYRIVDAKTGLFEAGYVTVEDMLSRQPWPEPGDEFP FT VHVTTQRGTPSKP" FT CDS 226806..228227 FT /transl_table=11 FT /locus_tag="Rv1432" FT /product="PROBABLE DEHYDROGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM" FT /EC_number="1.-.-.-" FT /note="Rv1432, (MTCY493.22c), len: 473 aa. Probable FT dehydrogenase (EC 1.-.-.-), shows strong simlarity to FT P49_STRLI|P06108 p49 protein from Streptomyces lividans FT (469 aa), FASTA scores: opt: 1362, E(): 0, (44.9% identity FT in 474 aa overlap); and weak simlarity to other FT dehydrogenases." FT /db_xref="GOA:O06826" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:O06826" FT /protein_id="CAB09252.1" FT /translation="MTTAVVVGAGPNGLAAAIHLARHGVDVQVLEARDTIGGGARSGEL FT TVPGVIHDHCSAFHPLGVGSPFWAAIDLQRYGLTWKWPDVDCAHPLDDGTAGVLYRSIE FT ATAAGLGPDGKRWQRAVGDLAAGFDELAEDLLRPVLNMPRHPIRLARFGPRAALPATAM FT ARRFHTERARALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKAL FT AAALDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTRINRSYRRYRA FT GSSAFKVDFAIEGDVGWTNPDCRRAGTVHLGGTFAEIADTERQRAQGTMVQRPFVLVGQ FT QYLADPSRSVGNINPIWAYAHVPFGYTGDATAAVIDQIERFAPGFRDRIVATVSTSTTE FT LQTYNRNFIGGDIIGGANDRLQVIFRPRVAVDPYAIGVPGVYLCSQSAPPGAGIHGLCG FT YHAAESALRWLRKRR" FT CDS 228391..229206 FT /transl_table=11 FT /locus_tag="Rv1433" FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT /function="UNKNOWN" FT /note="Rv1433, (MTCY493.21c), len: 271 aa. Possible FT exported protein with N-terminal signal sequence, highly FT similar to Q49706 hypothetical protein from Mycobacterium FT leprae (271 aa), FASTA scores: opt: 1341, E(): 0, (68.3% FT identity in 271 aa overlap). Also shows similarity to M. FT tuberculosis lipoprotein Rv2518c|MTV009.03c lppS (408 aa) FT (40.0% identity in 230 aa overlap); and others e.g. FT Rv0116c, Rv0192, Rv2518c, Rv0483." FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:O06825" FT /protein_id="CAB09251.1" FT /translation="MRAVFGCAIAVVGIAGSVVAGPADIHLVAAKQSYGFAVASVLPTR FT GQVVGVAHPVVVTFSAPITNPANRHAAERAVEVKSTPAMTGKFEWLDNDVVQWVPDRFW FT PAHSTVELSVGSLSSDFKTGPAVVGVASISQHTFTVSIDGVEEGPPPPLPAPHHRVHFG FT EDGVMPASMGRPEYPTPVGSYTVLSKERSVIMDSSSVGIPVDDPDGYRLSVDYAVRITS FT RGLYVHSAPWALPALGLENVSHGCISLSREDAEWYYNAVDIGDPVIVQE" FT CDS 229213..229350 FT /transl_table=11 FT /locus_tag="Rv1434" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1434, (MTCY493.20c), len: 45 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O06824" FT /protein_id="CAB09250.1" FT /translation="MRASPAERVDGAYAGAGPHTQSVLEEDQRQRAPAGAEAEGPGRTG FT " FT CDS complement(229299..229907) FT /transl_table=11 FT /locus_tag="Rv1435c" FT /product="Probable conserved Proline, Glycine, Valine-rich FT secreted protein" FT /function="UNKNOWN" FT /note="Rv1435c, (MTCY493.19), len: 202 aa. Probable FT conserved Pro-, Gly-, Val-rich secreted protein (see FT citation below) with a N-terminal signal sequence. Similar FT at C-terminus to AF017099|AF017099_1 Mycobacterium FT tuberculosis pGB1 (87 aa), FASTA scores: opt: 550, E(): FT 2.3e-17, (97.7% identity in 86 aa overlap). Shows some FT similarity to N-terminus of CPN_DROME|Q02910 calphotin. FT drosophila melanogaster (865 aa), FASTA scores: opt: 266, FT E(): 2.5e-05, (37.2% identity in 191 aa overlap). Contains FT at least five 7 aa imperfect repeats. Also shows similarity FT to other Mycobacterium tuberculosis proteins e.g. FT MTCI237.20c (34.7% identity in 193 aa overlap), MTCI65.25c FT (36.9% identity in 160 aa overlap) and MTCI65.24c (34.2% FT identity in 196 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06823" FT /protein_id="CAB09249.1" FT /translation="MTLMAIVNRFNIKVIAGAGLFAAAIALSPDAAADPLMTGGYACIQ FT GMAGDAPVAAGDPVAAGGPAAAGACSAALTDMAGVPFVAPGPVPAAAPVPIGAPVPIPG FT APVPIPGAPVPIPGGPVPIPGAPVPVPAVPAPVIPVGTPLIALGPVLAGAPGDGVVSAP FT IIGMSGVKDALTDPAPAGGPVPGQPVLPGPSASAPAGAR" FT repeat_region complement(229515..229535) FT /note="21 bp imperfect direct repeat 5, FT GGCGCACCGGTACCGGTACCC" FT repeat_region complement(229536..229556) FT /note="21 bp imperfect direct repeat 4, FT GGCGGACCGGTACCGATACCG" FT repeat_region complement(229557..229577) FT /note="21 bp imperfect direct repeat 3, FT GGCGCACCGGTACCAATCCCC" FT repeat_region complement(229578..229598) FT /note="21 bp imperfect direct repeat 2, FT GGCGCACCGGTACCGATACCG" FT repeat_region complement(229599..229619) FT /note="21 bp imperfect direct repeat 1, FT GGCGCACCGGTACCAATCCCT" FT CDS 230264..231283 FT /transl_table=11 FT /gene="gap" FT /locus_tag="Rv1436" FT /product="PROBABLE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FT GAP (GAPDH)" FT /function="INVOLVED IN SECOND PHASE OF GLYCOLYSIS (FIRST FT STEP) [CATALYTIC ACTIVITY: D-GLYCERALDEHYDE 3-PHOSPHATE + FT PHOSPHATE + NAD(+) = 3-PHOSPHO-D-GLYCEROYL PHOSPHATE + FT NADH.]" FT /EC_number="1.2.1.12" FT /note="Rv1436, (MTCY493.18c), len: 339 aa. Probable gap, FT Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), FT highly similar to many e.g. G3P_MYCLE|P46713 Mycobacterium FT leprae (339 aa), FASTA scores: opt: 1933, E():0, (89.1% FT identity in 339 aa overlap). Contains PS00071 FT Glyceraldehyde 3-phosphate dehydrogenase active site. FT BELONGS TO THE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FT FAMILY." FT /db_xref="GOA:P64178" FT /db_xref="HSSP:1CER" FT /db_xref="InterPro:IPR006424" FT /db_xref="UniProtKB/Swiss-Prot:P64178" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09248.1" FT /translation="MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNST FT LAHLLKFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVVVEST FT GLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCL FT APLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAI FT GLVMPQLKGKLDGYALRVPIPTGSVTDLTVDLSTRASVDEINAAFKAAAEGRLKGILKY FT YDAPIVSSDIVTDPHSSIFDSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL" FT misc_feature 230729..230752 FT /note="PS00071 Glyceraldehyde 3-phosphate dehydrogenase FT active site" FT CDS 231286..232524 FT /transl_table=11 FT /gene="pgk" FT /locus_tag="Rv1437" FT /product="PROBABLE PHOSPHOGLYCERATE KINASE PGK" FT /function="INVOLVED IN THE SECOND PHASE OF GLYCOLYSIS FT (SECOND STEP) [CATALYTIC ACTIVITY : ATP + FT 3-PHOSPHO-D-GLYCERATE = ADP + 3-PHOSPHO-D-GLYCEROYL FT PHOSPHATE]" FT /EC_number="2.7.2.3" FT /note="Rv1437, (MTCY493.17c), len: 412 aa. Probable pgk, FT Phosphoglycerate kinase (EC 2.7.2.3), highly similar to FT many e.g. PGK_MYCLE|P46712 Mycobacterium leprae (416 aa), FT FASTA scores: opt: 2153, E(): 0, (80.4% identity in 414 aa FT overlap). Contains PS00111 Phosphoglycerate kinase FT signature. BELONGS TO THE PHOSPHOGLYCERATE KINASE FAMILY." FT /db_xref="GOA:P65700" FT /db_xref="HSSP:1VPE" FT /db_xref="InterPro:IPR015824" FT /db_xref="UniProtKB/Swiss-Prot:P65700" FT /protein_id="CAB09247.1" FT /translation="MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASA FT PTLKALLDADAKVVVAAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGADAL FT ARAEGLTGGDILLLENIRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVHRK FT QASVYDIATLLPHYAGTLVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATK FT ADSIVIGGGMCFTFLAAQGFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFA FT ADSPPQTVDVGAVPNGLMGLDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPAYAAGTR FT GVAEAIVAATGKGAFSVVGGGDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGI FT EVLSREQPTGGVL" FT misc_feature 232255..232278 FT /note="PS00111 Phosphoglycerate kinase signature" FT CDS 232521..233306 FT /transl_table=11 FT /gene="tpi" FT /locus_tag="Rv1438" FT /product="PROBABLE TRIOSEPHOSPHATE ISOMERASE TPI (TIM)" FT /function="PLAYS AN IMPORTANT ROLE IN SEVERAL METABOLIC FT PATHWAYS [CATALYTIC ACTIVITY : D-GLYCERALDEHYDE 3-PHOSPHATE FT = GLYCERONE PHOSPHATE]" FT /EC_number="5.3.1.1" FT /note="Rv1438, (MTCY493.16c), len: 261 aa. Probable tpi FT (tpiA), Triosephosphate isomerase (EC 5.3.1.1), highly FT similar to many e.g. TPIS_MYCLE|P46711 Mycobacterium leprae FT (261 aa), FASTA scores: opt: 1456, E(): 0, (83.9% identity FT in 261 aa overlap). Contains PS00171 Triosephosphate FT isomerase active site. BELONGS TO THE TRIOSEPHOSPHATE FT ISOMERASE FAMILY." FT /db_xref="GOA:P66940" FT /db_xref="InterPro:IPR000652" FT /db_xref="PDB:3GVG" FT /db_xref="UniProtKB/Swiss-Prot:P66940" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09268.1" FT /translation="MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIP FT PFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERR FT TYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQ FT IGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAK FT NVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAGGPLP" FT misc_feature 233028..233060 FT /note="PS00171 Triosephosphate isomerase active site" FT CDS complement(233918..234343) FT /transl_table=11 FT /locus_tag="Rv1439c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1439c, (MTCY493.15), len: 141 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O06820" FT /protein_id="CAB09267.1" FT /translation="MQMSASNAFVEGFADFWKAPSPDRLTDHLHPDVVLVRPLSPPRHG FT LGAAQREFTRILGLLPDLHGEVDRWSQAGDVVFIEFRLIARLGSEVVEWPVVDRFLLRG FT DKAVERVSYFDSLPLLIKVVKHPSAWRGWLTTMRSRA" FT CDS 234794..235027 FT /transl_table=11 FT /gene="secG" FT /locus_tag="Rv1440" FT /product="PROBABLE PROTEIN-EXPORT MEMBRANE PROTEIN FT (TRANSLOCASE SUBUNIT) SECG" FT /function="INVOLVED IN PROTEIN EXPORT. PARTICIPATES IN A FT EARLY EVENT OF PROTEIN TRANSLOCATION." FT /note="Rv1440, (MTCY493.14c), len: 77 aa. Probable secG, FT protein-export membrane protein (translocase subunit) (see FT citation below), similar to many e.g. P38388|SECG_MYCLE FT PROBABLE PROTEIN-EXPORT MEMBRANE (77 aa), FASTA scores: FT opt: 450, E(): 6.7e-24, (96.1% identity in 77 aa overlap). FT Start changed since original submission (-40 aa). PART OF FT THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH FT COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, FT SECF|Rv2586c, SECG AND SECY|Rv0732." FT /db_xref="GOA:P66791" FT /db_xref="InterPro:IPR004692" FT /db_xref="UniProtKB/Swiss-Prot:P66791" FT /protein_id="CAB09266.2" FT /translation="MELALQITLIVTSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSGS FT TVVEKNLDRLTLFVTGIWLVSIIGVALLIKYR" FT CDS complement(235166..236641) FT /transl_table=11 FT /gene="PE_PGRS26" FT /locus_tag="Rv1441c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1441c, (MTCY493.13), len: 491 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see Brennan & Delogu 2002), similar to FT Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa FT protein (498 aa), fasta scores: opt: 1625, E(): 0, (55.2% FT identity in 518 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FP3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55389.1" FT /translation="MSNVMVVPGMLSAAAADVASIGAALSAANGAAAPTTAGVLAAGAD FT EVSAAIASLFSGYARDYQALSAQMARFHQQFVQALTASVGSYAAAEAANASPLQALEQQ FT VLAAINAPTQTLLGRPLIGNGADGLPGQNGGAGGLLWGNGGNGGAGDAAHPNGGNGGDA FT GMFGNGGAGGAGYSPAAGTGAAGGAGGAGGAGGWLSGNGGAGGNGGTGASGADGGGGLP FT PVPASPGGNGGGGDAGGAAGMFGTGGAGGTGGDGGAGGAGDSPNSGANGARGGDGGNGA FT AGGAGGRLFGNGGAGGNGGTAGQGGDGGTALGAGGIGGDGGTGGAGGTGGTAGIGGSSA FT GAGGAGGDGGAGGTGGGSSMIGGKGGTGGNGGVGGTGGASALTIGNGSSAGAGGAGGAG FT GTGGTGGYIESLDGKGQAGNGGNGGNGAAGGAGGGGTGAGGNGGAGGNGGDGGPSQGGG FT NPGFGGDGGTGGPGGVGVPDGIGGANGAQGKHG" FT CDS 236748..239048 FT /transl_table=11 FT /gene="bisC" FT /locus_tag="Rv1442" FT /product="PROBABLE BIOTIN SULFOXIDE REDUCTASE BISC (BDS FT reductase) (BSO reductase)" FT /function="THIS ENZYME MAY SERVE AS A SCAVENGER, ALLOWING FT THE CELL TO UTILIZE BIOTIN SULFOXIDE AS A BIOTIN SOURCE" FT /EC_number="1.-.-.-" FT /note="Rv1442, (MTCY493.12c), len: 766 aa. Probable bisC, FT Biotin sulfoxide reductase (EC 1.-.-.-), similar to FT BISC_ECOLI|P20099 biotin sulfoxide reductase from FT Escherichia coli (739 aa), FASTA scores: opt: 1271, E():0, FT (40.2% identity in 744 aa overlap)." FT /db_xref="GOA:O06817" FT /db_xref="HSSP:1EU1" FT /db_xref="InterPro:IPR009010" FT /db_xref="UniProtKB/TrEMBL:O06817" FT /protein_id="CAB09264.1" FT /translation="MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGAV FT RHRSRIANPAVRRGWLQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAI FT YGSSYGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAALFEALA FT ETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSVSPLR FT DDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERY FT LLGLDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMA FT ATLAAMLGQIGLPGGGFGHGYSSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQ FT RPGQRLAYNGRLLELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMA FT KHADIVVPTTTSFERDDFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQ FT FTEGRSAREWLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAH FT PLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQPRTRLH FT SQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRP FT KVVQLSTGAWFDPADPRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGE FT LPPVRAHEPPRLA" FT CDS complement(239164..239649) FT /transl_table=11 FT /locus_tag="Rv1443c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1443c, (MTCY493.11), len: 161 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/TrEMBL:O06816" FT /protein_id="CAB09263.1" FT /translation="MVGYAEPVLIERQSVVAAPAEQVWQRVVTPEGINDELRPWMTMSV FT PRGAKGMTVDTVPIGAPIGRAWLRLFGVLPFDYDRLSIAELEPGRRFREDSTMLSMRQW FT QHERTVTPEGDTKTIVRDRITFQTRAGLRFAAPLIAAGLRALFGHRHRRLQRHFAQG" FT CDS complement(240244..240654) FT /transl_table=11 FT /locus_tag="Rv1444c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1444c, (MTCY493.10), len: 136 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O06815" FT /protein_id="CAB09262.1" FT /translation="MTVMADRSGRPAPVRRRMKTLTQAALNADKTVEQVEDVLDGLGKT FT MAELNSSLSQLNSTVERLEDGLDHLEGTLHSLDDLAKRLIVLVEPVEAIVDRIDYIVSL FT GETVMSPLSVTEHAVRGVLDRLRNRTVHEPTN" FT CDS complement(240671..241414) FT /transl_table=11 FT /gene="devB" FT /locus_tag="Rv1445c" FT /product="PROBABLE 6-PHOSPHOGLUCONOLACTONASE DEVB (6PGL)" FT /function="INVOLVED IN PENTOSE PHOSPHATE PATHWAY. FT HYDROLYSIS OF 6-PHOSPHOGLUCONOLACTONE TO 6- FT PHOSPHOGLUCONATE. [CATALYTIC ACTIVITY : FT 6-PHOSPHO-D-GLUCONO-1,5-LACTONE + H(2)O = 6- FT PHOSPHO-D-GLUCONATE]" FT /EC_number="3.1.1.31" FT /note="Rv1445c, (MTCY493.09), len: 247 aa. Possible devB FT (PGL), 6-phosphogluconolactonase (EC 3.1.1.31), belongs to FT a different family to the upstream gene zwf2. Similar to FT e.g. DEVB_ANASP|P46016 putative glucose-6-phosphate FT 1-dehydrogenase (239 aa), FASTA scores: opt: 439, E(): FT 2.6e-20, (34.0% identity in 247 aa overlap). BELONGS TO THE FT GLUCOSAMINE/GALACTOSAMINE-6-PHOSPHATE ISOMERASE FAMILY. FT 6-PHOSPHOGLUCONOLACTONASE SUBFAMILY." FT /db_xref="GOA:P63338" FT /db_xref="InterPro:IPR006148" FT /db_xref="UniProtKB/Swiss-Prot:P63338" FT /protein_id="CAB09261.1" FT /translation="MSSSIEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGN FT GIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHP FT MAASDGDFGGDLDAAALAYEQVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAV FT LESTRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSV FT PAAGAVGRQNTLWLLDRDAAAKLPS" FT CDS complement(241411..242322) FT /transl_table=11 FT /gene="opcA" FT /locus_tag="Rv1446c" FT /product="PUTATIVE OXPP CYCLE PROTEIN OPCA" FT /function="MAY BE INVOLVED IN THE FUNCTIONAL ASSEMBLY OF FT GLUCOSE 6-PHOSPHATE DEHYDROGENASE" FT /note="Rv1446c, (MTCY493.08), len: 303 aa. Putative opcA, FT OxPP cycle protein. Highly similar to S72774 B1496_F1_30 FT protein from Mycobacterium leprae (265 aa), FASTA scores: FT opt: 1056, E(): 0, (70.3% identity in 239 aa overlap). Also FT similar to OPCA_NOSS2|P48971 putative oxppcycle protein FT opca from Nostoc punctiforme (465 aa), fasta scores: opt: FT 177, E(): 7.3e-05, (23.4% identity in 321 aa overlap). AIDS FT IN G6PD ACTIVITY." FT /db_xref="InterPro:IPR019297" FT /db_xref="UniProtKB/TrEMBL:O06813" FT /protein_id="CAB09260.1" FT /translation="MIVDLPDTTTTAVNKKLDELREKIGAVAMGRVLTLIIAPDSEAML FT EESIEAANDASHEHPSRIIVTMRGDPYADRPRLDAQLRVGADAGAGEFVVLRLSGPLAG FT HADSVVIPFLLPDIPVVAWWPDIAPAVPAQDALGKLAIRRITDATNAIDPLSAIKSRLA FT GYGAGDTDLAWSRITYWRALLTSAVDQPRHEPIESALVSGLKTEPALDVLAGWLASRIE FT GPVRRAVGELKVELVRNSETIVLSRPQEGITATLTRTGKPDALVPLARRVTGECLAEDL FT RRLDPDEIYCAALEGIKKVQYR" FT repeat_region complement(242323..242375) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS complement(242375..243919) FT /transl_table=11 FT /gene="zwf2" FT /locus_tag="Rv1447c" FT /product="PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 FT (G6PD)" FT /function="INVOLVED IN PENTOSE PHOSPHATE PATHWAY [CATALYTIC FT ACTIVITY : D-GLUCOSE 6-PHOSPHATE + NADP(+) = D-GLUCONO- FT 1,5-LACTONE 6-PHOSPHATE + NADPH]" FT /EC_number="1.1.1.49" FT /note="Rv1447c, (MTCY493.07), len: 514 aa. Probable zwf2 FT (ZWF), Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), FT highly similar to many e.g. G6PD_SYNY3|P73411 Synechocystis FT sp. (509 aa), FASTA scores: opt: 1578, E(): 0, (46.8% FT identity in 509 aa overlap). Also similar to M. FT tuberculosis Rv1121, zwf glucose-6-phosphate FT 1-dehydrogenase. Contains PS00069 Glucose-6-phosphate FT dehydrogenase active site. Mycobacterium tuberculosis has FT two genes for ZWF. This one looks like a classical ZWF. FT BELONGS TO THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY." FT /db_xref="GOA:P0A584" FT /db_xref="HSSP:1QKI" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P0A584" FT /protein_id="CAB09259.1" FT /translation="MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKV FT MPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEG FT FRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLAR FT PQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFA FT NQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEP FT VSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTT FT ETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNA FT MVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEP FT SLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP" FT misc_feature complement(243287..243307) FT /note="PS00069 Glucose-6-phosphate dehydrogenase active FT site" FT CDS complement(243916..245037) FT /transl_table=11 FT /gene="tal" FT /locus_tag="Rv1448c" FT /product="PROBABLE TRANSALDOLASE TAL" FT /function="TRANSALDOLASE IS IMPORTANT FOR THE BALANCE OF FT METABOLITES IN THE PENTOSE-PHOSPHATE PATHWAY [CATALYTIC FT ACTIVITY : SEDOHEPTULOSE 7-PHOSPHATE + D-GLYCERALDEHYDE FT 3-PHOSPHATE = D-ERYTHROSE 4-PHOSPHATE + D-FRUCTOSE FT 6-PHOSPHATE]" FT /EC_number="2.2.1.2" FT /note="Rv1448c, (MTCY493.06), len: 373 aa. Probable tal, FT Transaldolase (EC 2.2.1.2), highly similar to many e.g. FT TAL_MYCLE|P55193 transaldolase from Mycobacterium leprae FT (375 aa), FASTA scores: opt: 1891, E(): 0, (78.6% identity FT in 370 aa overlap). BELONGS TO THE TRANSALDOLASE FAMILY." FT /db_xref="GOA:O06812" FT /db_xref="InterPro:IPR014634" FT /db_xref="UniProtKB/Swiss-Prot:O06812" FT /protein_id="CAB09258.1" FT /translation="MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGV FT TTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDG FT VDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGIS FT VNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIG FT SRQALELRGQAGVANARLAYATYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYS FT DTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGTASDAQAVFDQLGAIGIDLTD FT VFAVLEEEGVRKFEASWNELLQETRAHLDTAAQ" FT CDS complement(245054..247156) FT /transl_table=11 FT /gene="tkt" FT /locus_tag="Rv1449c" FT /product="PROBABLE TRANSKETOLASE TKT (TK)" FT /function="This enzyme, together with transaldolase, FT provides a link between the glycolytic and FT pentose-phosphate pathways. It catalyzes the reversible FT transfer of a two-carbon ketol unit from xylulose FT 5-phosphate to an aldose receptor [CATALYTIC ACTIVITY: FT Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = FT D-ribose 5-phosphate + D-xylulose 5-phosphate]" FT /EC_number="2.2.1.1" FT /note="Rv1449c, (MTCY493.05), len: 700 aa. Probable tkt, FT Transketolase (EC 2.2.1.1). Highly similar to several e.g. FT TKT_MYCLE|P46708 transketolase (tk) from Mycobacterium FT leprae (699 aa), FASTA scores: opt: 4216, E(): 0, (89.1% FT identity in 700 aa overlap). Start site chosen by homology. FT Contains PS00801 Transketolase signature 1. BELONGS TO THE FT TRANSKETOLASE FAMILY. Thought to be differentially FT expressed within host cells (see Triccas et al., 1999)." FT /db_xref="GOA:O06811" FT /db_xref="HSSP:1TRK" FT /db_xref="InterPro:IPR005475" FT /db_xref="UniProtKB/Swiss-Prot:O06811" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09272.1" FT /translation="MTTLEEISALTRPRHPDYWTEIDSAAVDTIRVLAADAVQKVGNGH FT PGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELS FT DIESLRTWGSKTPGHPEFRHTPGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPG FT ASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDRNQISIEDDTNIALCED FT TAARYRAYGWHVQEVEGGENVVGIEEAIANAQAVTDRPSFIALRTVIGYPAPNLMDTGK FT AHGAALGDDEVAAVKKIVGFDPDKTFQVREDVLTHTRGLVARGKQAHERWQLEFDAWAR FT REPERKALLDRLLAQKLPDGWDADLPHWEPGSKALATRAASGAVLSALGPKLPELWGGS FT ADLAGSNNTTIKGADSFGPPSISTKEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTR FT AYGGTFLQFSDYMRPAVRLAALMDIDTIYVWTHDSIGLGEDGPTHQPIEHLSALRAIPR FT LSVVRPADANETAYAWRTILARRNGSGPVGLILTRQGVPVLDGTDAEGVARGGYVLSDA FT GGLQPGEEPDVILIATGSEVQLAVAAQTLLADNDILARVVSMPCLEWFEAQPYEYRDAV FT LPPTVSARVAVEAGVAQCWHQLVGDTGEIVSIEHYGESADHKTLFREYGFTAEAVAAAA FT ERALDN" FT misc_feature complement(247004..247066) FT /note="PS00801 Transketolase signature 1" FT CDS complement(247595..251584) FT /transl_table=11 FT /gene="PE_PGRS27" FT /locus_tag="Rv1450c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1450c, (MTCY493.04), len: 1329 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to FT Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa FT protein (603 aa), fasta scores: opt: 2112, E(): 0, (56.5% FT identity in 630 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FP2" FT /protein_id="CAE55390.1" FT /translation="MSLVIVAPETVAAAALDVARIGSSIGAANAAAAGSTTSVLAAGAD FT EVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHN FT VLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGAGGA FT AGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGV FT GGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGGAAGLL FT GVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAGGAGGAG FT GVGGTGGAGGAGFSRALIVAGDNGGDPGAGGAGGTGGAGSTIGAHGAAGASPTSGGNGG FT AGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGAGGAGGNGAPGAPPSGGDPNGGGGGAGG FT AGGKGGDGGAQAGDGGAGGAGGKGGNGGNGATGATGLNGLGAGADGTDGGKGGNGGAGG FT GGGAGGQGGKALAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGG FT NGGSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGANATVAGGAGGAGGKGG FT NGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGG FT TGGAGGNGANGANATTPGAKGGDGGHGGPGAQGGNGGQGGPGGLAGNLFGQNGIQGVGG FT SGGKGGAGGLAGDGGNGANGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAH FT GFTPTSGGDGGDGGNGGNSQVVGGNGGDGGNGGNGGSAGTGGNGGRGGDGAFGGMSANA FT TNPGENGPNGNPGGNGGAGGAGGAGLNGGNGGAGGNGGLGGFGGNGAAGANGVAVGAPG FT QPGGAGGHGGAGGNGGAGGNGGQGVVSDGAGGAGGAGGDGGAPGDGANGGNGQGAGAFA FT GGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGGHGAASGGNGGP FT GGHGGNGGNGGTGANGGNGGIGGTGGAGSTGAKGVLGTNEGDGGDGGRGGNGGRGGNGG FT QGLTGAGGNGGTGGTPGNGGNGGNGASGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSG FT PGGTPGDWGTGGTGGTGGTGGQGANGGLTGGRGGTGGNGGNGNTGGTGGAGGTGGTGHN FT GSQPGMGGNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAGPFGTGTGGTGGHGGQGG FT GGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGLGGGEFV" FT repeat_region complement(250488..251747) FT /note="1260 bp imperfect direct repeat 2, first copy at FT 1637133..1638392" FT CDS 251986..252912 FT /transl_table=11 FT /gene="ctaB" FT /locus_tag="Rv1451" FT /product="PROBABLE CYTOCHROME C OXIDASE ASSEMBLY FACTOR FT CTAB" FT /function="THOUGHT TO BE INVOLVED IN AEROBIC RESPIRATION." FT /note="Rv1451, (MTCY493.03c), len: 308 aa. Probable ctaB, FT cytochrome C oxidase assembly factor, and integral membrane FT protein. Highly similar to several Mycobacterium leprae FT proteins e.g. Q49685 CYOE cytochrome O ubiquinol oxidase FT assembly factor (300 aa), FASTA scores: opt: 1636, E(): 0, FT (82.7% identity in 307 aa overlap); NP_301495.1|NC_002677 FT putative protoheme IX farnesyltransferase (321 aa); FT NP_301495.1|NC_002677 putative protoheme IX FT farnesyltransferase (321 aa)." FT /db_xref="GOA:O06809" FT /db_xref="InterPro:IPR000537" FT /db_xref="UniProtKB/Swiss-Prot:O06809" FT /protein_id="CAB09270.1" FT /translation="MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLL FT ADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADADIDKVMKRTARRPLAREAVPTRNAL FT ALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMP FT VMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQV FT TKQILIYTWLTVAATLVLALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRL FT FLQSNNYLAVVFCALAVDSVIALPTLH" FT CDS complement(252961..255186) FT /transl_table=11 FT /gene="PE_PGRS28" FT /locus_tag="Rv1452c" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv1452c, (MTCY493.02), len: 741 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to FT Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa FT protein (603 aa), fasta scores: opt: 2090, E(): 0, (56.3% FT identity in 641 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FP1" FT /protein_id="CAE55391.1" FT /translation="MSLVIVTPETVAAAASDVARIGSSIGVANSAAAGSTTSVLAAGAD FT EVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHN FT VLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGAGGA FT AGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGV FT GGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGGAAGLL FT GVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAGGAGGAG FT GVGGTGGAGGAGFSRALIVAGDNGGDGGNGGMGGAGGAGGPGGAGGLISLLGGQGAGGA FT GGTGGAGGVGGDRGAGGPGNQAFNAGAGGAGGHGGDPGAGGAGGTGGAGSITGAQGAIG FT ATPTSGGNGGAGGNGANATTAGTNGANGGPGGHGGLVGNGGAGGNGANGAAGTNASDSG FT AVGGKGNSGGNGGQGGAGGDGGTLAGNGGAGGTGGRGADGGLGGSGAEGANATTAGERG FT QDGGKGGNGGVGGTGGNAVAPGANGGHGGNGGNPGFSGAGGLGGLSGDGVTRAAQGATP FT DFADTGGKGGNGGNGANAVAPGGTGASGGAGGNAGAGGKGGENIIGDGGGGNGGAGGKG FT GAGTLLGLTVFGDNGGAGVLGDSTDPDGSGGAGGAGGAGGAGGDPTI" FT repeat_region complement(254090..255349) FT /note="1260 bp imperfect direct repeat 1, second copy at FT 1633531..1634790" FT CDS 255338..256603 FT /transl_table=11 FT /locus_tag="Rv1453" FT /product="POSSIBLE TRANSCRIPTIONAL ACTIVATOR PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1453, (MTCY493.01c), len: 421 aa. Possible FT transcriptional activator, similar to Q50018 putative FT transcriptional activator trx from Mycobacterium leprae FT (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity FT in 500 aa overlap). Also highly similar to Mycobacterium FT tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c, FT and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% FT identity in 335 aa overlap). Start changed since first FT submission (-11 aa)." FT /db_xref="UniProtKB/TrEMBL:O06807" FT /protein_id="CAB09273.2" FT /translation="MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAA FT DPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALDIY FT RIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERDKLT FT RDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLDRVAD FT AFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIEG FT FRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASP FT ALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQ FT QWREKPTSDPPAKKESNGTKMR" FT CDS complement(256631..257617) FT /transl_table=11 FT /gene="qor" FT /locus_tag="Rv1454c" FT /product="PROBABLE QUINONE REDUCTASE QOR (NADPH:quinone FT reductase) (Zeta-crystallin homolog protein)" FT /function="Catalyzes the one electron reduction of certain FT quinones [CATALYTIC ACTIVITY: NADPH + quinone = NADP+ + FT semiquinone]" FT /EC_number="1.6.5.5" FT /note="Rv1454c, (MTV007.01c), len: 328 aa. Probable qor, FT quinone oxidoreductase (EC 1.6.5.5), simiar to FT U87282|RCU87282_2 quinone oxidoreductase from Rhodobacter FT capsulatus (323 aa), FASTA scores: opt: 849, E(): 0, (44.7% FT identity in 329 aa overlap). Also similar to MTCY180.06 FT Hypothetical protein from Mycobacterium tuberculosis (334 FT aa), FASTA scores: opt: 430, E(): 2e-14, (32.3% identity in FT 350 aa overlap). TBparse score is 0.887. Contains PS01162 FT Quinone oxidoreductase / zeta-crystallin signature." FT /db_xref="GOA:O53146" FT /db_xref="HSSP:1QOR" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O53146" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA15984.1" FT /translation="MHAIEVTETGGPGVLRHVDQPQPQPGHGELLIKAEAIGVNFIDTY FT FRSGQYPRELPFVIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASANGAYAEFCTAPA FT SLTAKVPDDVTSEVAASALLKGLTAHYLLKSVYPVKRGDTVLVHAGAGGVGLILTQWAT FT HLGVRVITTVSTAEKAKLSKDAGADVVLDYPEDAWQFAGRVRELTGGTGVQAVYDGVGA FT TTFDASLASLAVRGTLALFGAASGPVPPVDPQRLNAAGSVYLTRPSLFHFTRTGEEFSW FT RAAELFDAIGSEAITVAVGGRYPLADALRAHQDLEARKTVGSVVLLP" FT misc_feature complement(257138..257191) FT /note="PS01162 Quinone oxidoreductase / zeta-crystallin FT signature" FT CDS 257637..258500 FT /transl_table=11 FT /locus_tag="Rv1455" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1455, (MTV007.02), len: 287 aa. Conserved FT hypothetical protein, some similarity from aa 80-160 to FT Z99125|MLCL536.35c hypothetical Mycobacterium leprae FT protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, FT (51.3% identity in 78 aa overlap). TBparse score is 0.915." FT /db_xref="UniProtKB/TrEMBL:O53147" FT /protein_id="CAA15985.1" FT /translation="MKLARPDVFHPRVVLAGWPQQPAGDGDDAGLVAALRHRGLHAGWL FT SWDDPEIVHADLVILRATRDYPARLDEFLAWTTRVANLLNSRPVVAWNVERRYLRDLMD FT RGVPTVPGEVYVPGEPVRLPRKGQVFVGPTIGTGTRRCSARFAAEFVAQLHAAGQAVLV FT QPGGSGDETVLVFLGGEPSHAFTKQADTWRQTEPDFEIWDVGAAAVAGAAAQVGVDPGE FT LLYARAHITGGSRDPRLLELQLVDPSLGWQWLDPDIRNLAQRDFALCVQSALERLGLGP FT FSHRRP" FT CDS complement(258450..259382) FT /transl_table=11 FT /locus_tag="Rv1456c" FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT FT INTEGRAL MEMBRANE ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT ANTIBIOTIC ACROSS THE MEMBRANE (EXPORT): UNIDENTIFIED FT ANTIBIOTIC RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE FT FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE FT MEMBRANE." FT /note="Rv1456c, (MTV007.03c), len: 310 aa. Possible FT unidentified antibiotic-transport integral membrane protein FT ABC transporter (see citation below), equivalent to FT Z99125|MLCL536.34 from Mycobacterium leprae (311 aa), FASTA FT scores: opt: 1607, E(): 0, (83.3% identity in 300 aa FT overlap). TBparse score is 0.886." FT /db_xref="GOA:O53148" FT /db_xref="InterPro:IPR003780" FT /db_xref="UniProtKB/TrEMBL:O53148" FT /protein_id="CAA15986.1" FT /translation="MPYDRAVSPSLRVQRVIAAIVILTQGGIAVTGAIVRVTASGLGCP FT TWPQCFPGSFTPVVVAEVPRVHQAVEFGNRMVTFAVVIAAALAVLVVTRARRRTEVLAY FT AWLMPVSTVVQAMIGGITVRTGLLWWTVAIHLLASMTMVWLAVLLYVKIGQPDDGVVHE FT LVVSPLRALTALSALNLAAVLVTGTLVTAAGPHAGDRSPSRTVPRLKVEITTLVHMHSS FT LLVAYLALLIGLGFGLLAVGATRAILVRLAVLLALVATQAAVGTTQYFTGVPAALVAIH FT VAGAAAVTAATAALWASMGERAQPQPLQR" FT CDS complement(259494..260279) FT /transl_table=11 FT /locus_tag="Rv1457c" FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT FT INTEGRAL MEMBRANE ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT ANTIBIOTIC ACROSS THE MEMBRANE (EXPORT): UNIDENTIFIED FT ANTIBIOTIC RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE FT FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE FT MEMBRANE." FT /note="Rv1457c, (MTV007.04c), len: 261 aa. Possible FT unidentified antibiotic-transport integral membrane protein FT ABC transporter (see citation below), equivalent to FT Z99125|MLCL536.32 from Mycobacterium leprae (265 aa), FASTA FT scores: opt: 1415, E(): 0, (83.1% identity in 260 aa FT overlap). TBparse score is 0.877." FT /db_xref="GOA:O86349" FT /db_xref="InterPro:IPR013525" FT /db_xref="UniProtKB/TrEMBL:O86349" FT /protein_id="CAA15987.1" FT /translation="MTQTNRPAFPAGTFSPDPRPNAVPLMLAAQFSLELKLLLRNGEQL FT LLTMFIPITLLVGLTLLPMGSFGHNRAATFVPVIMALAVISTAFTGQAIAVAFDRRYGA FT LKRLGATPLPVWGIIAGKSLAVVAVVFLQAIILGAIGFALGWRPALTALTLGAGIIALG FT TAGFAALGLLLGGTLRAEIVLAVANLMWFVFAGFGALTLESNVIPTAFKWVARVTPSGA FT LTEALSQAMTVSVDWFGIVVLAVWGALAALAALRWFRFT" FT CDS complement(260276..261217) FT /transl_table=11 FT /locus_tag="Rv1458c" FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT ANTIBIOTIC ACROSS THE MEMBRANE (EXPORT): UNIDENTIFIED FT ANTIBIOTIC RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE FT FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM." FT /note="Rv1458c, (MTV007.05c), len: 313 aa. Possible FT unidentified antibiotic-transport ATP-binding protein ABC FT transporter (see citation below), equivalent to FT Z99125|MLCL536.31 from Mycobacterium leprae (315 aa), FASTA FT scores: opt: 1812, E(): 0, (88.0% identity in 308 aa FT overlap). Similar to AF027770|AF027770_7 ABC-type FT transporter in FxbA region in Mycobacterium smegmatis (284 FT aa), FASTA scores: opt: 1412, E(): 0, (85.1% identity in FT 248 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop) and PS00211 ABC transporters family FT signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FT FAMILY (ABC TRANSPORTERS). TBparse score is 0.874." FT /db_xref="GOA:O53149" FT /db_xref="HSSP:1JI0" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:O53149" FT /protein_id="CAA15988.1" FT /translation="MNRAPDTPEVVLRLRGVCKRYGSITAVSNLDLDVHDAEVMALLGP FT NGAGKTTTVEMCEGFVRPDAGSIEVLGLDPITDNARLRARIGVMLQGGGGYPAARAGEM FT LDLVASYAANPLDPHWLLDTLGLTEAARTTYRRLSGGQQQRLALACALVGRPQLVFLDE FT PTAGMDAHARVLVWELIDALRRDGVTVVLTTHHLKEAEELADRLVIIDHGVTVAAGTPA FT ELMRSGAKDQLRFTAPPRLDLSLLASALPEGYQATELTPGEYLVEGPVDPQVLATVTAW FT CAQIDVLATDMRVEQRSLEDVFLDLTGRKLRQ" FT misc_feature complement(260762..260806) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(261065..261088) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT repeat_region complement(261218..261270) FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region complement(261271..261321) FT /note="51 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS complement(261320..263095) FT /transl_table=11 FT /locus_tag="Rv1459c" FT /product="POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv1459c, (MTV007.06c), len: 591 aa. Possible FT conserved integral membrane protein, equivalent to FT MLCL536.30|Z99125 hypothetical protein from Mycobacterium FT leprae (593 aa), FASTA scores: opt: 1670, E(): 0, (78.6% FT identity in 585 aa overlap). Also similar to M. FT tuberculosis protein Rv2174|MTV021.07 (33.1% identity in FT 523 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O53150" FT /protein_id="CAA15989.1" FT /translation="MAARHHTLSWSIASLHGDEQAVGAPLTTTELTALARTRLFGATGT FT VLMAIGALGAGARPVVQDPTFGVRLLNLPSRIQTVSLTMTTTGAVMMALAWLMLGRFTL FT GRRRMSRGKLDRTLLLWMLPLLIAPPMYSKDVYSYLAQSEIGRDGLDPYRVGPASGLGL FT GHVFTLSVPSLWRETPAPYGPLFLWIGRGISSLTGENIVAAVLCHRLVVLIGVTLIVWA FT TPRLAQRCGVAEVSALWLGAANPLLIMHLVAGIHNEALMLGLMLTGVEFALRGLDMANT FT PRPSPETWRLGPATIRASRRPELGASPRAGASRAVKPRPEWGPLAMLLAGSILITLSSQ FT VKLPSLLAMGFVTTVLAYRWGGNLRALLLAAAVMASLTLAIMAILGWASGLGFGWINTL FT GTANVVRSWMSPPTLLALGTGHVGILLGLGDHTTAVLSLTRAIGVLIITVMVCWLLLAV FT LRGRLHPIGGLGVALAVTVLLFPVVQPWYLLWAIIPLAAWATRPGFRVAAILATLIVGI FT FGPTANGDRFALFQIVDATAASAIIVILLIALTYTRLPWRPLAAEQVVTAAESASKTPA FT TRRPTAAPDAYADST" FT CDS 263143..263949 FT /transl_table=11 FT /locus_tag="Rv1460" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv1460, (MTV007.07), len: 268 aa. Probable FT transcriptional regulatory protein. Equivalent to FT Z99125|MLCL536.29c hypothetical protein from Mycobacterium FT leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% FT identity in 250 aa overlap). Possible helix-turn-helix FT motif between aa 68 - 89. Start changed since original FT submission. TBparse score is 0.904." FT /db_xref="InterPro:IPR013196" FT /db_xref="UniProtKB/TrEMBL:O53151" FT /protein_id="CAA15990.2" FT /translation="MTSTTLPHRASLVDRSTEFCHTDVVKIPAVSTTVPAAVSDGHTRR FT AIVRLLLESGSITAGEIGDRLGLSAAGVRRHLDALIEAGDAEASAAAPWQQVGRGRPAK FT RYRLTAAGRAKLDHSYDDLASAAMRQLREIGGEEAVRTFARRRIDAILADVAPADGPDD FT AALEAAAERIATALSKAGYVATTTRVGGPIHGVQICQHHCPVSHVAEEFPELCETEQQA FT MAEVLGTHVQRLATIVNGDCACTTHVPLSPAPSPRPPATSTEGASR" FT CDS 263946..266486 FT /transl_table=11 FT /locus_tag="Rv1461" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1461, (MTV007.08), len: 846 aa. Conserved FT hypothetical protein. Equivalent of spliced protein from FT Mycobacterium leprae MLCL536.28c len: 869. Residues 1-253 FT represent N-extein, and 613-846 the C-extein. The intein FT present from residues 254 - 612 is different in sequence FT and site of the insertion from the one present in FT MLCL536.28c. FASTA scores: Z99125|MLCL536_23 Mycobacterium FT leprae cosmid L536 (869 aa), opt: 1498 E(): 0, (54.1% FT identity in 917 aa overlap). The mature protein is similar FT to Z99120|BSUB0017_150 hypothetical Bacillus subtilis FT protein (465 aa), FASTA scores: opt:1053, E(): 0, (34.8% FT identity in 821 aa overlap). The intein shows some FT similarity to inteins from U67548|MJU67548_6 Methanococcus FT jannaschii (895 aa), FASTA scores: opt: 181, E(): 0.00023, FT (25.2% identity in 274 aa overlap). TBparse score is FT 0.913." FT /db_xref="GOA:P67125" FT /db_xref="HSSP:1LWT" FT /db_xref="InterPro:IPR000825" FT /db_xref="UniProtKB/Swiss-Prot:P67125" FT /protein_id="CAA15991.1" FT /translation="MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGAN FT AQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVR FT STEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGV FT IFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQA FT YFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTG FT HDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWK FT AEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHAC FT LTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAM FT RDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAF FT QLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFA FT VPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHA FT RVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEV FT LSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSS FT VKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFYLMSRGLTEDEAMAM FT VVRGFVEPIAKELPMEYALELNRLIELQMEGAVG" FT CDS 266483..267676 FT /transl_table=11 FT /locus_tag="Rv1462" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv1462, (MTV007.09), len: 397 aa. Conserved FT hypothetical protein. Equivalent to MLCL536.27c|Z99125 FT hypothetical protein from Mycobacterium leprae (392 aa), FT FASTA scores: opt: 2059, E(): 0, (80.4% identity in 392 aa FT overlap). Also similar to nearby Mycobacterium tuberculosis FT hypothetical protein Rv1461. TBparse score is 0.873." FT /db_xref="GOA:O53153" FT /db_xref="InterPro:IPR011542" FT /db_xref="UniProtKB/Swiss-Prot:O53153" FT /protein_id="CAA15992.1" FT /translation="MTAPGLTAAVEGIAHNKGELFASFDVDAFEVPHGRDEIWRFTPLR FT RLRGLHDGSARATGSATITVSERPGVYTQTVRRGDPRLGEGGVPTDRVAAQAFSSFNSA FT TLVTVERDTQVVEPVGITVTGPGEGAVAYGHLQVRIEELGEAVVVIDHRGGGTYADNVE FT FVVDDAARLTAVWIADWADNTVHLSAHHARIGKDAVLRHVTVMLGGDVVRMSAGVRFCG FT AGGDAELLGLYFADDGQHLESRLLVDHAHPDCKSNVLYKGALQGDPASSLPDAHTVWVG F |