EBI Dbfetch

ID   BX842575; SV 1; linear; genomic DNA; STD; PRO; 349306 BP.
XX
AC   BX842575; AL010186; AL021006; AL021897; AL021999; Z79700; Z92539; Z93777;
AC   Z94752; Z95209-Z95210; Z95584-Z95585; Z98260;
XX
DT   21-NOV-2003 (Rel. 77, Created)
DT   23-OCT-2008 (Rel. 97, Last updated, Version 6)
XX
DE   Mycobacterium tuberculosis H37Rv complete genome; segment 4/13
XX
KW   complete genome.
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
XX
RN   [1]
RX   DOI; 10.1038/31159
RX   PUBMED; 9634230.
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence";
RL   Nature 393(6685):537-544(1998).
XX
RN   [2]
RX   PUBMED; 12368430.
RA   Camus J.C., Pryor M.J., Medigue C., Cole S.T.;
RT   "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv";
RL   Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002).
XX
RN   [3]
RP   1-349306
RA   Parkhill J.;
RT   ;
RL   Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases.
RL   Submitted on behalf of the Mycobacterium tuberculosis sequencing and
RL   mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton,
RL   Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut
RL   Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
RL   parkhill@sanger.ac.uk
XX
DR   EMBL-CON; AL123456.
DR   RFAM; RF00174; Cobalamin.
XX
CC   Notes:
CC   Details of M. tuberculosis sequencing at the Sanger Centre
CC   are available on the World Wide Web.
CC   (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/)
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..349306
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:83332"
FT   CDS             complement(53..844)
FT                   /transl_table=11
FT                   /locus_tag="Rv0927c"
FT                   /product="PROBABLE SHORT-CHAIN TYPE
FT                   DEHYDROGENASE/REDUCTASE"
FT                   /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv0927c, (MTCY21C12.21c), len: 263 aa. Probable
FT                   short-chain dehydrogenase/reductase (EC 1.-.-.-), similar
FT                   to various dehydrogenases/reductases, notably
FT                   7-alpha-hydroxysteroid dehydrogenases and glucose
FT                   1-dehydrogenases e.g. P25529|HDHA_ECOLI
FT                   7-alpha-hydroxysteroid dehydrogenase from Escherichia coli
FT                   (255 aa), FASTA scores: opt: 551, E(): 1e-26, (39.5%
FT                   identity in 248 aa overlap); NP_252778.1|NC_002516 probable
FT                   short-chain dehydrogenase from Pseudomonas aeruginosa (253
FT                   aa); AAC44307.1|U59433 3-ketoacyl-acyl carrier protein
FT                   reductase from Bacillus subtilis (246 aa); etc. Also
FT                   similar to other dehydrogenases from Mycobacterium
FT                   tuberculosis e.g. MTCY09F9.36, E():1.4e-18; MTCY369.14,
FT                   E():8e-17; MTCY02B10.14, E():2.5e-14; MTCY09F9.23c,
FT                   E():1.5e-13; MTCY03C7.07, E():1.9e-13. Contains PS00061
FT                   Short-chain dehydrogenases/reductases family signature, and
FT                   PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO
FT                   THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY."
FT                   /db_xref="GOA:O05919"
FT                   /db_xref="HSSP:1AHI"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O05919"
FT                   /protein_id="CAB08497.1"
FT                   /translation="MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSS
FT                   ELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLL
FT                   STSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTA
FT                   KAALAHYTRLAALDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDP
FT                   VDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL"
FT   misc_feature    complement(113..136)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   misc_feature    complement(320..406)
FT                   /note="PS00061 Short-chain alcohol dehydrogenase family
FT                   signature"
FT   CDS             1116..2228
FT                   /transl_table=11
FT                   /gene="pstS3"
FT                   /locus_tag="Rv0928"
FT                   /standard_name="phoS2"
FT                   /product="PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS3
FT                   (PBP-3) (PSTS3) (PHOS1)"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC
FT                   PHOSPHATE ACROSS THE MEMBRANE (IMPORT). THIS IS ONE OF THE
FT                   PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED PHOSPHATE
FT                   TRANSPORT."
FT                   /note="Rv0928, (MTCY21C12.22), len: 370 aa. pstS3
FT                   (previously known as phoS2), phosphate-binding lipoprotein
FT                   component of inorganic phosphate transport system (see
FT                   citations below), highly similar to others from
FT                   Mycobacterium leprae e.g. Q50099|PSTS3|PHOS1
FT                   phosphate-binding protein 3 precursor (328 aa), FASTA
FT                   scores: opt: 1772, E(): 0, (79.6% identity in 328 aa
FT                   overlap); and highly similar to others e.g.
FT                   AAF74819.1|AF137360_1|AF137360 periplasmic phosphate
FT                   permease from Mycobacterium avium (369 aa). Also highly
FT                   similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING
FT                   PERIPLASMIC LIPOPROTEIN (370 aa); and Rv0934|pstS1
FT                   PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (374 aa) from
FT                   Mycobacterium tuberculosis (Mycobacterium tuberculosis
FT                   seems to have three PstS-like proteins, others being
FT                   Rv0932c and Rv0934c). Contains lipoprotein signature
FT                   (PS00013) at N-terminus. BELONGS TO FAMILY OF PHOSPHATE
FT                   RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS."
FT                   /db_xref="GOA:P0A5Y2"
FT                   /db_xref="HSSP:1IXH"
FT                   /db_xref="InterPro:IPR006059"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5Y2"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55337.1"
FT                   /translation="MKLNRFGAAVGVLAAGALVLSACGNDDNVTGGGATTGQASAKVDC
FT                   GGKKTLKASGSTAQANAMTRFVNVFEQACPGQTLNYTANGSGAGISEFNGNQTDFGGSD
FT                   VPLSKDEAAAAQRRCGSPAWNLPVVFGPIAVTYNLNSVSSLNLDGPTLAKIFNGSITQW
FT                   NNPAIQALNRDFTLPGERIHVVFRSDESGTTDNFQRYLQAASNGAWGKGAGKSFQGGVG
FT                   EGARGNDGTSAAAKNTPGSITYNEWSFAQAQHLTMANIVTSAGGDPVAITIDSVGQTIA
FT                   GATISGVGNDLVLDTDSFYRPKRPGSYPIVLATYEIVCSKYPDSQVGTAVKAFLQSTIG
FT                   AGQSGLGDNGYIPIPDEFKSRLSTAVNAIA"
FT   misc_feature    1152..1184
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             2241..3215
FT                   /transl_table=11
FT                   /gene="pstC2"
FT                   /locus_tag="Rv0929"
FT                   /product="PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC
FT                   TRANSPORTER PSTC2"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC
FT                   PHOSPHATE ACROSS THE MEMBRANE (IMPORT); RESPONSIBLE FOR THE
FT                   TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. THIS IS
FT                   ONE OF THE PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED
FT                   PHOSPHATE TRANSPORT."
FT                   /note="Rv0929, (MTCY21C12.23), len: 324 aa. pstC2,
FT                   phosphate-transport integral membrane ABC transporter (see
FT                   citations below), highly similar to others e.g.
FT                   NP_302394.1|NC_002677 membrane-bound component of phosphate
FT                   transport from Mycobacterium leprae (319 aa);
FT                   CAB88474.1|AL353816 phosphate ABC transport system permease
FT                   protein from Streptomyces coelicolor (336 aa); NP_290359.1|
FT                   NC_002655 high-affinity phosphate-specific transport system
FT                   (cytoplasmic membrane component) from Escherichia coli
FT                   strain O157:H7 (319 aa); etc. Also similar to
FT                   Rv935|MTCY08D9.04c|PSTC1 PROBABLE TRANSMEMBRANE ABC
FT                   TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from
FT                   Mycobacterium tuberculosis (338 aa). Contains
FT                   binding-protein-dependent transport systems inner membrane
FT                   component signature (PS00402)."
FT                   /db_xref="GOA:P0A630"
FT                   /db_xref="InterPro:IPR011864"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A630"
FT                   /protein_id="CAB08489.1"
FT                   /translation="MVTEPLTKPALVAVDMRPARRGERLFKLAASAAGSTIVIAILLIA
FT                   IFLLVRAVPSLRANHANFFTSTQFDTSDDEQLAFGVRDLFMVTALSSITALVLAVPVAV
FT                   GIAVFLTHYAPRRLSRPFGAMVDLLAAVPSIIFGLWGIFVLAPKLEPIARFLNRNLGWL
FT                   FLFKQGNVSLAGGGTIFTAGIVLSVMILPIVTSISREVFRQTPLIQIEAALALGATKWE
FT                   VVRMTVLPYGRSGVVAASMLGLGRALGETVAVLVILRSAARPGTWSLFDGGYTFASKIA
FT                   SAASEFSEPLPTGAYISAGFALFVLTFLVNAAARAIAGGKVNG"
FT   misc_feature    2844..2930
FT                   /note="PS00402 Binding-protein-dependent transport systems
FT                   inner membrane comp signature"
FT   CDS             3212..4138
FT                   /transl_table=11
FT                   /gene="pstA1"
FT                   /locus_tag="Rv0930"
FT                   /product="PROBABLE PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE
FT                   ABC TRANSPORTER PSTA1"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC
FT                   PHOSPHATE ACROSS THE MEMBRANE (IMPORT); RESPONSIBLE FOR THE
FT                   TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. THIS IS
FT                   ONE OF THE PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED
FT                   PHOSPHATE TRANSPORT."
FT                   /note="Rv0930, (MTCY21C12.24), len: 308 aa. Probable pstA1,
FT                   phosphate-transport integral membrane ABC transporter (see
FT                   citation below), highly similar to others e.g.
FT                   NP_302393.1|NC_002677 membrane-bound component of phosphate
FT                   transport from Mycobacterium leprae (304 aa);
FT                   CAB88473.1|AL353816 phosphate ABC transport system permease
FT                   protein from Streptomyces coelicolor (354 aa) (N-terminus
FT                   longer); NP_312689.1|NC_002695 phosphate transport system
FT                   permease protein PstA from Escherichia coli strain O157:H7
FT                   (296 aa); etc. Also similar to Rv0936|MTCY08D9.03c|PSTA2
FT                   PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF
FT                   PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis
FT                   (301 aa)."
FT                   /db_xref="GOA:O86345"
FT                   /db_xref="InterPro:IPR005672"
FT                   /db_xref="UniProtKB/Swiss-Prot:O86345"
FT                   /protein_id="CAB08490.2"
FT                   /translation="MSPSMSIEALDQPVKPVVFRPLTLRRRIKNSVATTFFFTSFVVAL
FT                   IPLVWLLWVVIARGWFAVTRSGWWTHSLRGVLPEQFAGGVYHALYGTLVQAGVAAVLAV
FT                   PLGLMTAVYLVEYGTGRMSRVTTFTVDVLAGVPSIVAALFVFSLWIATLGFQQSAFAVA
FT                   LALVLLMLPVVVRAGEEMLRLVPDELREASYALGVPKWKTIVRIVAPIAMPGIVSGILL
FT                   SIARVVGETAPVLVLVGYSHSINLDVFHGNMASLPLLIYTELTNPEHAGFLRVWGAALT
FT                   LIIVVATINLAAAMIRFVATRRRRLPL"
FT   CDS             complement(4133..6127)
FT                   /transl_table=11
FT                   /gene="pknD"
FT                   /locus_tag="Rv0931c"
FT                   /standard_name="mbk"
FT                   /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D
FT                   PKND (PROTEIN KINASE D) (STPK D)"
FT                   /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA
FT                   PHOSPHORYLATION). THOUGHT TO REGULATE PHOSPHATE TRANSPORT.
FT                   CAN PHOSPHORYLATE THE PEPTIDE SUBSTRATE MYELIN BASIC
FT                   PROTEIN (MBP) AT SERINE AND THREONINE RESIDUES. CAN BE
FT                   AUTOPHOSPHORYLATED ON THREONINE RESIDUES [CATALYTIC
FT                   ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]."
FT                   /EC_number="2.7.1.-"
FT                   /note="Rv0931c, (MTCY08D9.08), len: 664 aa. pknD (alternate
FT                   gene name: mbk), transmembrane serine/threonine protein
FT                   kinase (EC 2.7.1.-) (see citations below), equivalent to
FT                   CAB62227.1|AJ250200 putative serine/threonine protein
FT                   kinase from Mycobacterium bovis BCG (291 aa); and highly
FT                   similar in N-terminus to P54744|PKNB_MYCLE probable
FT                   serine/threonine-specific protein kinase (EC 2.7.1.-) from
FT                   Mycobacterium leprae (622 aa). Also highly similar to
FT                   others, particularly in N-terminal half e.g.
FT                   NP_243370.1|NC_002570 serine/threonine protein kinase from
FT                   Bacillus halodurans (664 aa); NP_268044.1|NC_002662
FT                   serine/threonine protein kinase from Lactococcus lactis
FT                   (627 aa); etc. Also highly similar to other
FT                   serine/threonine protein kinases from Mycobacterium
FT                   tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398,
FT                   E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa);
FT                   pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase
FT                   subdomain. Contains two transmembrane segments, which flank
FT                   a highly repetitive region, suggesting a receptor-like
FT                   anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN
FT                   KINASES. Experimental studies show evidence of
FT                   auto-phosphorylation on a serine residue. Appears to be
FT                   co-transcribed with Rv0932c|pstS2."
FT                   /db_xref="GOA:O05871"
FT                   /db_xref="InterPro:IPR008271"
FT                   /db_xref="PDB:1RWI"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05871"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08487.1"
FT                   /translation="MSDAVPQVGSQFGPYQLLRLLGRGGMGEVYEAEDTRKHRVVALKL
FT                   ISPQYSDNAVFRARMQREADTAGRLTEPHIVPIHDYGEINGQFFVEMRMIDGTSLRALL
FT                   KQYGPLTPARAVAIVRQIAAALDAAHANGVTHRDVKPENILVTASDFAYLVDFGIARAA
FT                   SDPGLTQTGTAVGTYNYMAPERFTGDEVTYRADIYALACVLGECLTGAPPYRADSVERL
FT                   IAAHLMDPAPQPSQLRPGRVPPALDQVIAKGMAKNPAERFMSAGDLAIAAHDALTTSEQ
FT                   HQATTILRRGDNATLLATPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSATVAGPLA
FT                   ADSRGGNWPSQTGHSPAVPNALQASLGHAVPPAGNKRKVWAVVGAAAIVLVAIVAAAGY
FT                   LVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGMYGRVVKLATGST
FT                   GTTVLPFNGLYQPQGLAVDGAGTVYVTDFNNRVVTLAAGSNNQTVLPFDGLNYPEGLAV
FT                   DTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYVTDTDNNRVV
FT                   KLEAESNNQVVLPFTDITAPWGIAVDEAGTVYVTEHNTNQVVKLLAGSTTSTVLPFTGL
FT                   NTPLAVAVDSDRTVYVADRGNDRVVKLTS"
FT   misc_feature    complement(5690..5728)
FT                   /note="PS00108 Serine/Threonine protein kinases active-site
FT                   signature"
FT   misc_feature    complement(5996..6067)
FT                   /note="PS00107 Protein kinases ATP-binding region
FT                   signature"
FT   CDS             complement(6149..7261)
FT                   /transl_table=11
FT                   /gene="pstS2"
FT                   /locus_tag="Rv0932c"
FT                   /product="PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS2
FT                   (PBP-2) (PSTS2)"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC
FT                   PHOSPHATE ACROSS THE MEMBRANE (IMPORT). THIS IS ONE OF THE
FT                   PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED PHOSPHATE
FT                   TRANSPORT."
FT                   /note="Rv0932c, (MTCY08D9.07), len: 370 aa. pstS2,
FT                   phosphate-binding lipoprotein component of inorganic
FT                   phosphate transport system (see citations below), highly
FT                   similar to AAF74819.1|AF137360_1|AF137360 periplasmic
FT                   phosphate permease from Mycobacterium avium (369 aa);
FT                   Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC
FT                   LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA
FT                   scores: opt: 1601, E(): 0, (64.5% identity in 372 aa
FT                   overlap); and Rv0934|MTCY08D9.05c|pstS1 PHOSPHATE-BINDING
FT                   PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis
FT                   (374 aa) (Mycobacterium tuberculosis seems to have three
FT                   PstS-like proteins, others being Rv0928 and Rv0934c). Also
FT                   highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN
FT                   ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374
FT                   aa), FASTA scores: opt: 460, E(): 2.7e-20, (31.2% identity
FT                   in 375 aa overlap). Contains prokaryotic membrane
FT                   lipoprotein lipid attachment site (PS00013) at N-terminus
FT                   so the leader peptide of 22 aa is probably removed. BELONGS
FT                   TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE
FT                   LIPOPROTEIN TRANSPORTERS. Appears to be co-transcribed with
FT                   Rv0931c|pknD|mbk."
FT                   /db_xref="GOA:O05870"
FT                   /db_xref="HSSP:1IXH"
FT                   /db_xref="InterPro:IPR006059"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05870"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55338.1"
FT                   /translation="MKFARSGAAVSLLAAGTLVLTACGGGTNSSSSGAGGTSGSVHCGG
FT                   KKELHSSGSTAQENAMEQFVYAYVRSCPGYTLDYNANGSGAGVTQFLNNETDFAGSDVP
FT                   LNPSTGQPDRSAERCGSPAWDLPTVFGPIAITYNIKGVSTLNLDGPTTAKIFNGTITVW
FT                   NDPQIQALNSGTDLPPTPISVIFRSDKSGTSDNFQKYLDGASNGAWGKGASETFNGGVG
FT                   VGASGNNGTSALLQTTDGSITYNEWSFAVGKQLNMAQIITSAGPDPVAITTESVGKTIA
FT                   GAKIMGQGNDLVLDTSSFYRPTQPGSYPIVLATYEIVCSKYPDATTGTAVRAFMQAAIG
FT                   PGQEGLDQYGSIPLPKSFQAKLAAAVNAIS"
FT   misc_feature    complement(7193..7225)
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             7477..8307
FT                   /transl_table=11
FT                   /gene="pstB"
FT                   /locus_tag="Rv0933"
FT                   /product="PHOSPHATE-TRANSPORT ATP-BINDING PROTEIN ABC
FT                   TRANSPORTER PSTB"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC
FT                   PHOSPHATE ACROSS THE MEMBRANE (IMPORT); RESPONSIBLE FOR
FT                   ENERGY COUPLING TO THE TRANSPORT SYSTEM. THIS IS ONE OF THE
FT                   PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED PHOSPHATE
FT                   TRANSPORT. HAVE ATP-BINDING ABILITY AND ATPase ACTIVITY."
FT                   /note="Rv0933, (MTCY08D9.06c), len: 276 aa. pstB,
FT                   phosphate-transport ATP-binding protein ABC transporter
FT                   (see citations below), thermostable ATPase, highly similar
FT                   to others e.g. NP_348334.1|NC_003030 ATPase component of
FT                   ABC-type phosphate transport system from Clostridium
FT                   acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate
FT                   ABC transporter ATP-binding protein (pstB) from Borrelia
FT                   burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC
FT                   transporter (ATP-binding protein) from Bacillus subtilis
FT                   (269 aa), FASTA scores: opt: 762, E(): 0, (47.7% identity
FT                   in 243 aa overlap); etc. Also similar to other M.
FT                   tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15
FT                   and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC
FT                   transporters family signature, and PS00017 ATP/GTP-binding
FT                   site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT
FT                   PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium
FT                   seem to have no influence on the functionality of this
FT                   enzyme."
FT                   /db_xref="GOA:P95302"
FT                   /db_xref="InterPro:IPR005670"
FT                   /db_xref="UniProtKB/Swiss-Prot:P95302"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08485.1"
FT                   /translation="MACERLGGQSGAADVDAAAPAMAAVNLTLGFAGKTVLDQVSMGFP
FT                   ARAVTSLMGPTGSGKTTFLRTLNRMNDKVSGYRYSGDVLLGGRSIFNYRDVLEFRRRVG
FT                   MLFQRPNPFPMSIMDNVLAGVRAHKLVPRKEFRGVAQARLTEVGLWDAVKDRLSDSPFR
FT                   LSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRLTVIIVTHNL
FT                   AQAARISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVAGLSGDVKDAKRGN"
FT   misc_feature    7636..7659
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   misc_feature    7966..8010
FT                   /note="PS00211 ABC transporters family signature"
FT   CDS             8328..9452
FT                   /transl_table=11
FT                   /gene="pstS1"
FT                   /locus_tag="Rv0934"
FT                   /standard_name="phoS1; phoS"
FT                   /product="PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS1
FT                   (PBP-1) (PSTS1)"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC
FT                   PHOSPHATE ACROSS THE MEMBRANE (IMPORT). THIS IS ONE OF THE
FT                   PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED PHOSPHATE
FT                   TRANSPORT."
FT                   /note="Rv0934, (MTCY08D9.05c), len: 374 aa. pstS1
FT                   (previously known as phoS1 or phoS), phosphate-binding
FT                   lipoprotein component of inorganic phosphate transport
FT                   system (see citations below), highly similar to
FT                   Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC
FT                   LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA
FT                   scores: opt: 460, E(): 5.9e-19, (31.2% identity in 375 aa
FT                   overlap); and Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING
FT                   PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis
FT                   (374 aa), FASTA scores: opt: 435, E():1.1e-17, (30.0%
FT                   identity in 380 aa overlap) (Mycobacterium tuberculosis
FT                   seems to have three PstS-like proteins, others being
FT                   Rv0932c and Rv0928c). Also highly similar to
FT                   MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR
FT                   from Mycobacterium tuberculosis (374 aa), FASTA scores:
FT                   opt: 2459, E(): 0, (100% identity in 374 aa overlap).
FT                   Contains a prokaryotic membrane lipoprotein lipid
FT                   attachment site (PS00013) at the N-terminus so the 23 aa
FT                   leader peptide sequence is probably removed. BELONGS TO
FT                   FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE
FT                   LIPOPROTEIN TRANSPORTERS."
FT                   /db_xref="GOA:P15712"
FT                   /db_xref="InterPro:IPR006059"
FT                   /db_xref="PDB:1PC3"
FT                   /db_xref="UniProtKB/Swiss-Prot:P15712"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55339.1"
FT                   /translation="MKIRLHTLLAVLTAAPLLLAAAGCGSKPPSGSPETGAGAGTVATT
FT                   PASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNIGA
FT                   SDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKTWDD
FT                   PQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVDFPAV
FT                   PGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLPDAQSI
FT                   QAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQAFLHWAI
FT                   TDGNKASFLDQVHFQPLPPAVVKLSDALIATISS"
FT   misc_feature    8367..8399
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             9512..10528
FT                   /transl_table=11
FT                   /gene="pstC1"
FT                   /locus_tag="Rv0935"
FT                   /product="PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC
FT                   TRANSPORTER PSTC1"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC
FT                   PHOSPHATE ACROSS THE MEMBRANE (IMPORT); RESPONSIBLE FOR THE
FT                   TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. THIS IS
FT                   ONE OF THE PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED
FT                   PHOSPHATE TRANSPORT."
FT                   /note="Rv0935, (MTCY08D9.04c), len: 338 aa. pstC1,
FT                   phosphate-transport integral membrane ABC transporter (see
FT                   citations below), highly similar to others e.g.
FT                   NP_104768.1|NC_002678|pstC phosphate ABC transporter
FT                   permease protein from Mesorhizobium loti (327 aa);
FT                   NP_245372.1|NC_002663|PstC PstC protein from Pasteurella
FT                   multocida (320 aa); P45191|PSTC_HAEIN PHOSPHATE TRANSPORT
FT                   SYSTEM PERMEASE from Haemophilus influenza (315 aa), FASTA
FT                   scores: opt: 667, E(): 0, (36.2% identity in 309 aa
FT                   overlap); etc. Also similar to Rv0929|MTCY21C12.23|PSTC2
FT                   PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF
FT                   PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis
FT                   (324 aa), FASTA scores: opt: 487, E(): 4.1e-21, (32.3%
FT                   identity in 303 aa overlap); and shows slight similarity to
FT                   MTCY08D9.03c|PSTA2|Rv0936 PROBABLE TRANSMEMBRANE ABC
FT                   TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from
FT                   Mycobacterium tuberculosis (301 aa). Contains
FT                   binding-protein-dependent transport systems inner membrane
FT                   comp signature (PS00402)."
FT                   /db_xref="GOA:P0A628"
FT                   /db_xref="InterPro:IPR011864"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A628"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55340.1"
FT                   /translation="MLARAGEVGRAGPAIRWLGGIGAVIPLLALVLVLVVLVIEAMGAI
FT                   RLNGLHFFTATEWNPGNTYGETVVTDGVAHPVGAYYGALPLIVGTLATSAIALIIAVPV
FT                   SVGAALVIVERLPKRLAEAVGIVLELLAGIPSVVVGLWGAMTFGPFIAHHIAPVIAHNA
FT                   PDVPVLNYLRGDPGNGEGMLVSGLVLAVMVVPIIATTTHDLFRQVPVLPREGAIALGMS
FT                   NWECVRRVTLPWVSSGIVGAVVLGLGRALGETMAVAMVSGAVLGAMPANIYATMTTIAA
FT                   TIVSQLDSAMTDSTNFAVKTLAEVGLVLMVITLLTNVAARGMVRRVSRTALPVGRGI"
FT   misc_feature    10124..10210
FT                   /note="PS00402 Binding-protein-dependent transport systems
FT                   inner membrane comp signature"
FT   CDS             10530..11435
FT                   /transl_table=11
FT                   /gene="pstA2"
FT                   /locus_tag="Rv0936"
FT                   /product="PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC
FT                   TRANSPORTER PSTA2"
FT                   /function="INVOLVED IN ACTIVE TRANSPORT OF INORGANIC
FT                   PHOSPHATE ACROSS THE MEMBRANE (IMPORT); RESPONSIBLE FOR THE
FT                   TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. THIS IS
FT                   ONE OF THE PROTEINS REQUIRED FOR BINDING-PROTEIN-MEDIATED
FT                   PHOSPHATE TRANSPORT."
FT                   /note="Rv0936, (MTCY08D9.03c), len: 301 aa. pstA2,
FT                   phosphate-transport integral membrane ABC transporter (see
FT                   citations below), highly similar to others e.g.
FT                   NP_442269.1|NC_000911|PstA phosphate transport system
FT                   permease protein from Synechocystis sp. strain PCC 6803
FT                   (287 aa); NP_232473.1|NC_002506 phosphate ABC transporter
FT                   permease protein from Vibrio cholerae (289 aa);
FT                   P07654|PSTA_ECOLI PHOSPHATE TRANSPORT SYSTEM PERMEASE from
FT                   Escherichia coli (296 aa), FASTA scores: opt: 464, E():
FT                   6.7e-24, (30.5% identity in 282 aa overlap); etc. Also
FT                   similar to O86345|MTCY21C12.24|PSTA1|Rv0930 PROBABLE
FT                   TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE
FT                   SYSTEM from Mycobacterium tuberculosis (304 aa), FASTA
FT                   scores: opt: 369, E(): 6.1e-15, (32.7% identity in 248 aa
FT                   overlap). Contains binding-protein-dependent transport
FT                   systems inner membrane comp signature (PS00402)."
FT                   /db_xref="GOA:P0A626"
FT                   /db_xref="InterPro:IPR005672"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A626"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08482.1"
FT                   /translation="MGESAESGSRQLPAMSPPRRSVAYRRKIVDALWWAACVCCLAVVI
FT                   TPTLWMLIGVVSRAVPVFHWSVLVQDSQGNGGGLRNAIIGTAVLAIGVILVGGTVSVLT
FT                   GIYLSEFATGKTRSILRGAYEVLSGIPSIVLGYVGYLALVVYFDWGFSLAAGVLVLSVM
FT                   SIPYIAKATESALAQVPTSYREAAEALGLPAGWALRKIVLKTAMPGIVTGMLVALALAI
FT                   GETAPLLYTAGWSNSPPTGQLTDSPVGYLTYPIWTFYNQPSKSAQDLSYDAALLLIVFL
FT                   LLLIFIGRLINWLSRRRWDV"
FT   misc_feature    11055..11141
FT                   /note="PS00402 Binding-protein-dependent transport systems
FT                   inner membrane comp signature"
FT   CDS             complement(11412..12233)
FT                   /transl_table=11
FT                   /locus_tag="Rv0937c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0937c, (MTCY08D9.02), len: 273 aa. Conserved
FT                   hypothetical protein, highly similar to others e.g.
FT                   SC6G9.24c|T35620|AL079356 hypothetical protein from
FT                   Streptomyces coelicolor (365 aa), FASTA scores: opt: 648,
FT                   E(): 0, (36.5% identity in 274 aa overlap);
FT                   Z99110|BSUB0007_223|NP_389224.1|NC_000964 hypothetical
FT                   proteins from Bacillus subtilis (311 aa), FASTA scores:
FT                   opt: 623, E(): 1.1e-31, (33.9% identity in 274 aa overlap);
FT                   O28548|AE000984|AF1726|NP_070554.1|NC_000917 conserved
FT                   hypothetical protein from Archaeoglobus fulgidus (286 aa),
FT                   FASTA scores: opt: 583, E(): 0, (36.6% identity in 262 aa
FT                   overlap); etc."
FT                   /db_xref="GOA:O05866"
FT                   /db_xref="InterPro:IPR009187"
FT                   /db_xref="UniProtKB/TrEMBL:O05866"
FT                   /protein_id="CAB08491.1"
FT                   /translation="MRAIWTGSIAFGLVNVPVKVYSATADHDIRFHQVHAKDNGRIRYK
FT                   RVCEACGEVVDYRDLARAYESGDGQMVAITDDDIASLPEERSREIEVLEFVPAADVDPM
FT                   MFDRSYFLEPDSKSSKSYVLLAKTLAETDRMAIVHFTLRNKTRLAALRVKDFGKREVMM
FT                   VHTLLWPDEIRDPDFPVLDQKVEIKPAELKMAGQVVDSMADDFNPDRYHDTYQEQLQEL
FT                   IDTKLEGGQAFTAEDQPRLLDEPEDVSDLLAKLEASVKARSKANSNVPTPP"
FT   CDS             12349..14628
FT                   /transl_table=11
FT                   /locus_tag="Rv0938"
FT                   /product="POSSIBLE ATP DEPENDENT DNA LIGASE (ATP DEPENDENT
FT                   POLYDEOXYRIBONUCLEOTIDE SYNTHASE) (THERMOSTABLE DNA LIGASE)
FT                   (ATP DEPENDENT POLYNUCLEOTIDE LIGASE) (SEALASE) (DNA REPAIR
FT                   ENZYME) (DNA JOINASE)"
FT                   /function="THIS PROTEIN IS THOUGHT TO SEAL NICKS IN
FT                   DOUBLE-STRANDED DNA DURING DNA REPLICATION, DNA
FT                   RECOMBINATION AND DNA REPAIR [CATALYTIC ACTIVITY:ATP +
FT                   {DEOXYRIBONUCLEOTIDE}(N) + {DEOXYRIBONUCLEOTIDE}(M) = AMP +
FT                   DIPHOSPHATE + {DEOXYRIBONUCLEOTIDE}(N+M)]."
FT                   /EC_number="6.5.1.1"
FT                   /note="Rv0938, (MTCY08D9.01c, MTCY10D7.36c), len: 759 aa.
FT                   Possible ATP-dependent DNA ligase (EC 6.5.1.1), with its
FT                   C-terminus similar to N-terminal parts of many
FT                   ATP-dependent DNA ligases e.g. NP_250828.1|NC_002516
FT                   probable ATP-dependent DNA ligase from Pseudomonas
FT                   aeruginosa (840 aa); NP_105436.1|NC_002678 ATP-dependent
FT                   DNA ligase from Mesorhizobium loti (829 aa);
FT                   CAB92891.1|AL356932 probable ATP-dependent DNA ligase from
FT                   Streptomyces coelicolor (326 aa); etc. The N-terminal half
FT                   shows similarity with hypothetical proteins from
FT                   Mycobacterium tuberculosis Rv0269c and Rv3730c; and the
FT                   C-terminal half with the DNA ligases Rv3731 and Rv3062."
FT                   /db_xref="GOA:P71571"
FT                   /db_xref="InterPro:IPR014146"
FT                   /db_xref="PDB:2IRU"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71571"
FT                   /protein_id="CAB08492.1"
FT                   /translation="MGSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIA
FT                   GRPATRKRWPNGVDQPAFFEKQLALSAPPWLSRATVAHRSGTTTYPIIDSATGLAWIAQ
FT                   QAALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLLADI
FT                   GLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAG
FT                   KVFVDWSQNSGSKTTIAPYSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDG
FT                   DLLERLDADAPVADRLTRYRRMRDASKTPEPIPTAKPVTGDGNTFVIQEHHARRPHYDF
FT                   RLECDGVLVSWAVPKNLPDNTSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDS
FT                   GTYDTEKFHDDPHTGEVIVNLHGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNL
FT                   APMLATHGTVAGLKASQWAFEGKWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALA
FT                   EDLADHHVVLDGEAVVLDSSGVPSFSQMQNRGRDTRVEFWAFDLLYLDGRALLGTRYQD
FT                   RRKLLETLANATSLTVPELLPGDGAQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVK
FT                   DKHWNTQEVVIGGWRAGEGGRSSGVGSLLMGIPGPGGLQFAGRVGTGLSERELANLKEM
FT                   LAPLHTDESPFDVPLPARDAKGITYVKPALVAEVRYSEWTPEGRLRQSSWRGLRPDKKP
FT                   SEVVRE"
FT   CDS             14625..16559
FT                   /transl_table=11
FT                   /locus_tag="Rv0939"
FT                   /product="POSSIBLE BIFUNCTIONAL ENZYME:
FT                   2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD
FT                   ISOMERASE) + CYCLASE/DEHYDRASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM, POSSIBLY IN A DEGRADATION PATHWAY."
FT                   /EC_number="5.3.3.-"
FT                   /note="Rv0939, (MTCY10D7.35c), len: 644 aa. Possible
FT                   bifunctional enzyme, including
FT                   2-hydroxyhepta-2,4-diene-1,7-dioate isomerase activity (EC
FT                   5.3.3.-), and cyclase/dehydrase activity (EC undetermined).
FT                   N-terminal part similar to many isomerases e.g.
FT                   NP_343861.1|NC_002754 2-hydroxyhepta-2,4-diene-1,7-dioate
FT                   isomerase (hpcE-1) from Sulfolobus solfataricus (318 aa);
FT                   NP_068932.1|NC_000917 2-hydroxyhepta-2,4-diene-1,7-dioate
FT                   isomerase (hpcE-1) from Archaeoglobus fulgidus (324 aa),
FT                   FASTA scores: opt: 400, E(): 5.8e-15, (33.9% identity in
FT                   289 aa overlap); etc. And C-terminal part highly similar to
FT                   many cyclases/dehydrases e.g. AAK61721.1|AY033994
FT                   cyclase-like protein from Streptomyces aureofaciens (305
FT                   aa); CAC44204.1|AL593842 cyclase from Streptomyces
FT                   coelicolor (297 aa), FASTA scores: opt: 375, E(): 2.7e-26,
FT                   (35.6% identity in 284 aa overlap); NP_343860.1|NC_002754
FT                   putative Cyclase/dehydrase from Sulfolobus solfataricus
FT                   (308 aa); etc. Also similar to Rv2993c HYPOTHETICAL PROTEIN
FT                   from Mycobacterium tuberculosis."
FT                   /db_xref="GOA:O86346"
FT                   /db_xref="InterPro:IPR011234"
FT                   /db_xref="UniProtKB/TrEMBL:O86346"
FT                   /protein_id="CAB08493.1"
FT                   /translation="MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTA
FT                   GERAVRSPAAVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDTWYRI
FT                   PAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGYTIF
FT                   NDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIALVNGT
FT                   VIGSGSTAQMDWSFGEVIAYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFPGWLHD
FT                   GDVVTLQVEGLGETRQTVRTSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVA
FT                   DRVWAWTLPDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDAL
FT                   ITHSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLGPVATRYLRDR
FT                   FGHFDFSGIKLRNADLTFDRDLAIELGGRRVDLLNLGPAHTTADSVVHVADAGVLFAGD
FT                   LLFIGCTPIVWAGPIANWVAACDAMIALDAPTVVPGHGPVTGPDGIRAVRGYLAHIAEQ
FT                   AEAAYRKGLSLPEAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQ
FT                   AEWAARHCT"
FT   CDS             complement(16806..17672)
FT                   /transl_table=11
FT                   /locus_tag="Rv0940c"
FT                   /product="POSSIBLE OXIDOREDUCTASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv0940c, (MTCY10D7.34), len: 288 aa. Possible
FT                   oxidoreductase (EC 1.-.-.-), similar to hypothetical
FT                   proteins and oxidoreductases e.g.
FT                   AAK38097.1|AF323606_3|AF323606 putative F420-dependent
FT                   dehydrogenase from Rhodococcus erythropolis (295 aa);
FT                   AAG52987.1|AF040570|Rif17 putative alkanal monooxygenase
FT                   from Amycolatopsis mediterranei (356 aa); etc. Also similar
FT                   to putative oxidoreductases from Mycobacterium tuberculosis
FT                   such as Rv0953c|P71557|YT21_MYCTU (282 aa), FASTA scores:
FT                   opt: 311, E(): 3.7e-08, (31.0% identity in 248 aa overlap),
FT                   Rv3079c (275 aa), Rv0791c (347 aa), etc."
FT                   /db_xref="InterPro:IPR016048"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64761"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB01981.1"
FT                   /translation="MRFSYAEAMTDFTFYIPLAKAAEAAGYSSMTIPDSIAYPFESDSK
FT                   YPYTPDGNREFMDGKPFIETFVLTAALGAVTTRLRFNFFVLKLPIRPPALVAKQAGSLA
FT                   ALIGNRVGLGVGTSPWPEDYELMGVPFAKRGKRIDECIEIVRGLTTGDYFEFHGEFYDI
FT                   PKTKMTPAPTQPIPILVGGHADAALRRAARADGWMHGGGDPDELDRLIARVKRLREEAG
FT                   KTSPFEIHVISLDGFTVDGVKRLEDKGVTDVIVGFRVPYTMGPDTEPLQTKIRNLEMFA
FT                   ENVIAKV"
FT   CDS             complement(17757..18530)
FT                   /transl_table=11
FT                   /locus_tag="Rv0941c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0941c, (MTCY10D7.33), len: 257 aa. Conserved
FT                   hypothetical protein, showing some similarity with parts of
FT                   several hypothetical proteins from Streptomyces coelicolor
FT                   e.g. AL035161|SC9C7_20 (860 aa), FASTA scores: opt: 197,
FT                   E(): 2.6e-05, (34.2% identity in 114 aa overlap)."
FT                   /db_xref="InterPro:IPR002645"
FT                   /db_xref="UniProtKB/TrEMBL:P71568"
FT                   /protein_id="CAB01980.1"
FT                   /translation="MVAVSTAAKSPTALAIAVRTQDSVVILTADGALDSSSSALLRDSL
FT                   TRATLEQPSAVIVNVTELQVAEESAWSVFISARWQADFRADVPVLLVCGHRAGRAAVTR
FT                   TGVARFMPVYPTEKAASKAIGRLARRNFKRSDAQLPANLNSLRESRQLVREWLTQWSRP
FT                   GLIPVALVVVNVFVENVLKHTGSDPVMRIESDGPTATIAVSDGSSAPAVRLASPPKGID
FT                   VSGLAIVAALSRAWGSSPTSSGKTVWAIIGPENQL"
FT   CDS             18573..18851
FT                   /transl_table=11
FT                   /locus_tag="Rv0942"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0942, (MTCY10D7.32c), len: 92 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/Swiss-Prot:P64763"
FT                   /protein_id="CAB01979.1"
FT                   /translation="MGRSATIAMVPKRRDAMNRHSGPILSSGFIASSSNSCPANSLRMP
FT                   SALAAETLSFDDRAVRRSTHHPGGGYPQKHAINLQSGLCPAYANASR"
FT   CDS             complement(18909..19949)
FT                   /transl_table=11
FT                   /locus_tag="Rv0943c"
FT                   /product="PROBABLE MONOOXYGENASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv0943c, (MTCY10D7.31), len: 346 aa. Possible
FT                   monooxygenase (EC 1.-.-.-), similar in part to others e.g.
FT                   NP_250229.1|NC_002516 probable flavin-containing
FT                   monooxygenase from Pseudomonas aeruginosa (527 aa);
FT                   AAC36351.1|AF090329 cyclohexanone monooxygenase homolog
FT                   from Pseudomonas fluorescens (437 aa); CAB59668.1|AL132674
FT                   monooxygenase from Streptomyces coelicolor (519 aa); etc.
FT                   Also similar to putative monooxygenases from Mycobacterium
FT                   tuberculosis e.g. Rv1393c|P71662|CY21B4.10C (492 aa). FASTA
FT                   scores: opt: 129, E(): 8.5e-21, (27.5% identity in 236 aa
FT                   overlap); Rv0892 (495 aa); Rv3049c (524 aa); etc."
FT                   /db_xref="UniProtKB/Swiss-Prot:P64765"
FT                   /protein_id="CAB01978.1"
FT                   /translation="MAGVSEAERRGHRKLVRFQARRAIGPIRPTSAAWDRDFDPAGKRI
FT                   AVVGTDAAAAHYISRLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHPAV
FT                   AWATAAIDALTSSGIRTSDGVEHPVDAIIYGTGFAIADQVGDQTLVGAGGVTIRQAWDD
FT                   GMEPYLGVAVHGFPNYFFITGPDTAAQARCVVECMKLMERTASRRIEVRRSSQQVFNER
FT                   AQLKPAQPHRQTGGLEAFDLSSAATEDDQTYDGAATLTLAGARFRVRVRLTGHLDPIDG
FT                   NYHWQGTVFDSLPETSLTHARAATLTIGGRSAPARITEQTPWGTHSVAGVGPPPYARSG
FT                   PASATT"
FT   CDS             19978..20454
FT                   /transl_table=11
FT                   /locus_tag="Rv0944"
FT                   /product="POSSIBLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE
FT                   (FAPY-DNA GLYCOSYLASE)"
FT                   /function="THIS ENZYME MAY PLAY A SIGNIFICANT ROLE IN
FT                   PROCESSES LEADING TO RECOVERY FROM MUTAGENESIS AND/OR CELL
FT                   DEATH BY ALKYLATING AGENTS [CATALYTIC ACTIVITY: Hydrolysis
FT                   of DNA containing ring-opened N7-methylguanine residues,
FT                   releasing
FT                   2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide]."
FT                   /EC_number="3.2.2.23"
FT                   /note="Rv0944, (MTCY10D7.30c), len: 158 aa. Possible
FT                   formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), similar
FT                   to C-terminus of formamidopyrimidine-DNA glycosylases e.g.
FT                   CAB63194.1|AL133469 putative formamidopyrimidine-DNA
FT                   glycosylase from Streptomyces coelicolor (287 aa);
FT                   FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA
FT                   glycosylase (EC 3.2.2.23) from Lactococcus lactis subsp.
FT                   lactis (273 aa), FASTA scores: opt: 246, E(): 2.4e-09,
FT                   (28.9% identity in 142 aa overlap);
FT                   O50606|FPG_THETH|MUTM|FPG FORMAMIDOPYRIMIDINE-DNA
FT                   GLYCOSYLASE from Thermus thermophilus (267 aa); etc. Also
FT                   similar to C-termini of endonucleases or DNA glycosylases
FT                   of Mycobacterium tuberculosis e.g. Rv3297, Rv2464c,
FT                   Rv2924c. MAY BE BELONG TO THE FPG FAMILY."
FT                   /db_xref="GOA:P71565"
FT                   /db_xref="HSSP:1EE8"
FT                   /db_xref="InterPro:IPR015886"
FT                   /db_xref="UniProtKB/TrEMBL:P71565"
FT                   /protein_id="CAB01977.1"
FT                   /translation="MAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAG
FT                   IGNAYSDEILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKGEK
FT                   RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK"
FT   CDS             20460..21221
FT                   /transl_table=11
FT                   /locus_tag="Rv0945"
FT                   /product="PROBABLE SHORT-CHAIN TYPE
FT                   DEHYDROGENASE/REDUCTASE"
FT                   /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv0945, (MTCY10D7.29c), len: 253 aa. Probable
FT                   short-chain dehydrogenase/reductase (EC 1.-.-.-), similar
FT                   to various dehydrogenases/reductases e.g.
FT                   NP_346338.1|NC_003028 oxidoreductase (short chain
FT                   dehydrogenase/reductase family) from Streptococcus
FT                   pneumoniae (253 aa); AAB70845.1|AF019986|PksB from
FT                   Dictyostelium discoideum (260 aa); AAF86624.1|U87786
FT                   clavaldehyde dehydrogenase from Streptomyces clavuligerus
FT                   (247 aa); P37440|UCPA_ECOLI oxidoreductase from Escherichia
FT                   coli (285 aa), FASTA scores: opt: 275, E(): 1.1e-12, (33.8%
FT                   identity in 201 aa overlap); etc. Contains PS00061
FT                   Short-chain dehydrogenases/reductases family signature.
FT                   BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR)
FT                   FAMILY."
FT                   /db_xref="GOA:P71564"
FT                   /db_xref="HSSP:1IY8"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71564"
FT                   /protein_id="CAB02005.1"
FT                   /translation="MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRLT
FT                   ELKAELSQRYPDIKIAVAELDVNDHERVPKVFAELSDEIGGIDRVIVNAGIGKGARLGS
FT                   GKLWANKATIETNLVAALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYAASK
FT                   AGVRSLGESLRAEYAQRPIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVAAIER
FT                   EPGRAAVPWWPWAPLVRLMWVLPPRLTRRFA"
FT   misc_feature    20895..20981
FT                   /note="PS00061 Short-chain alcohol dehydrogenase family
FT                   signature"
FT   CDS             complement(21237..22898)
FT                   /transl_table=11
FT                   /gene="pgi"
FT                   /locus_tag="Rv0946c"
FT                   /product="PROBABLE GLUCOSE-6-PHOSPHATE ISOMERASE PGI (GPI)
FT                   (PHOSPHOGLUCOSE ISOMERASE) (PHOSPHOHEXOSE ISOMERASE) (PHI)"
FT                   /function="INVOLVED IN GLYCOLYSIS AND IN GLUCONEOGENESIS
FT                   [CATALYTIC ACTIVITY: D-glucose 6-phosphate = D-fructose
FT                   6-phosphate]."
FT                   /EC_number="5.3.1.9"
FT                   /note="Rv0946c, (MTCY10D7.28), len: 553 aa. Probable pgi,
FT                   glucose-6-phosphate isomerase (EC 5.3.1.9), equivalent to
FT                   NP_301236.1|NC_002677 glucose-6-phosphate isomerase from
FT                   Mycobacterium leprae (554 aa); and P96803|G6PI_MYCSM
FT                   GLUCOSE-6-PHOSPHATE ISOMERASE from Mycobacterium smegmatis
FT                   (442 aa). Also highly similar to others e.g. T36015
FT                   glucose-6-phosphate isomerase from Streptomyces coelicolor
FT                   (551 aa); P11537|G6PI_ECOLI|GPI glucose-6-phosphate
FT                   isomerase from Escherichia coli strains K12 and O157:H7
FT                   (549 aa), FASTA scores: opt: 1779, E(): 0, (51.4% identity
FT                   in 554 aa overlap); etc. Contains PS00765 Phosphoglucose
FT                   isomerase signature 1, and PS00174 Phosphoglucose isomerase
FT                   signature 2. BELONGS TO THE GPI FAMILY."
FT                   /db_xref="GOA:P64192"
FT                   /db_xref="HSSP:1HM5"
FT                   /db_xref="InterPro:IPR018189"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64192"
FT                   /protein_id="CAB02004.1"
FT                   /translation="MTSAPIPDITATPAWDALRRHHDQIGNTHLRQFFADDPGRGRELT
FT                   VSVGDLYIDYSKHRVTRETLALLIDLARTAHLEERRDQMFAGVHINTSEDRAVLHTALR
FT                   LPRDAELVVDGQDVVTDVHAVLDAMGAFTDRLRSGEWTGATGKRISTVVNIGIGGSDLG
FT                   PVMVYQALRHYADAGISARFVSNVDPADLIATLADLDPATTLFIVASKTFSTLETLTNA
FT                   TAARRWLTDALGDAAVSRHFVAVSTNKRLVDDFGINTDNMFGFWDWVGGRYSVDSAIGL
FT                   SLMTVIGRDAFADFLAGFHIIDRHFATAPLESNAPVLLGLIGLWYSNFFGAQSRTVLPY
FT                   SNDLSRFPAYLQQLTMESNGKSTRADGSPVSADTGEIFWGEPGTNGQHAFYQLLHQGTR
FT                   LVPADFIGFAQPLDDLPTAEGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAADGTPAHVV
FT                   AHKVMPGNRPSTSILASRLTPSVLGQLIALYEHQVFTEGVVWGIDSFDQWGVELGKTQA
FT                   KALLPVITGAGSPPPQSDSSTDGLVRRYRTERGRAG"
FT   misc_feature    complement(21357..21386)
FT                   /note="PS00174 Phosphoglucose isomerase signature 2"
FT   misc_feature    complement(22059..22094)
FT                   /note="PS00765 Phosphoglucose isomerase signature 1"
FT   CDS             complement(23516..23743)
FT                   /pseudo
FT                   /transl_table=11
FT                   /locus_tag="Rv0947c"
FT                   /product="PROBABLE MYCOLYL TRANSFERASE"
FT                   /function="UNKNOWN; THOUGHT TO BE INVOLVED IN MYCOLIC ACID
FT                   BIOSYNTHESIS."
FT                   /EC_number="2.-.-.-"
FT                   /note="Rv0947c, (MTCY10D7.27), len: 76 aa. Probable mycolyl
FT                   transferase pseudogene (EC 2.-.-.-), similar to part of
FT                   P31953|A85C_MYCTU|fbpC2 antigen 85-c precursor (85c)
FT                   (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium
FT                   tuberculosis (340 aa), FASTA scores: opt: 213, E(): 2e-08,
FT                   (69.6% identity in 46 aa overlap)."
FT   CDS             complement(23859..24176)
FT                   /transl_table=11
FT                   /locus_tag="Rv0948c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0948c, (MTCY10D7.26), len: 105 aa. Conserved
FT                   hypothetical protein, equivalent to NP_301237.1|NC_002677
FT                   conserved hypothetical protein from Mycobacterium leprae
FT                   (105 aa). Also similar (except in N-terminus) to
FT                   SCD63.16c|CAB82023.1|AL161755 hypothetical protein from
FT                   Streptomyces coelicolor (110 aa); and to N-terminus of two
FT                   chorismate mutase/prephenate dehydratase."
FT                   /db_xref="GOA:P64767"
FT                   /db_xref="InterPro:IPR010958"
FT                   /db_xref="PDB:2QBV"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64767"
FT                   /protein_id="CAB02002.1"
FT                   /translation="MRPEPPHHENAELAAMNLEMLESQPVPEIDTLREEIDRLDAEILA
FT                   LVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLG
FT                   H"
FT   CDS             24473..26788
FT                   /transl_table=11
FT                   /gene="uvrD1"
FT                   /locus_tag="Rv0949"
FT                   /standard_name="uvrD"
FT                   /product="PROBABLE ATP-DEPENDENT DNA HELICASE II UVRD1"
FT                   /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR. HAS A
FT                   3'-5' HELICASE ACTIVITY IN PRESENCE OF ATP. PREFERRED
FT                   SUBSTRATE BEING ONE WITH BOTH SINGLE AND DOUBLE STRANDED
FT                   REGIONS OF DNA."
FT                   /EC_number="3.6.1.-"
FT                   /note="Rv0949, (MTCY10D7.25c), len: 771 aa. Probable uvrD1,
FT                   ATP dependent DNA helicase II (EC 3.6.1.-) (see citation
FT                   below), equivalent to P_301239.1|NC_002677 putative
FT                   ATP-dependent DNA helicase from Mycobacterium leprae (778
FT                   aa). Also highly similar to others e.g. CAB92660.1|AL356832
FT                   from Streptomyces coelicolor (831 aa) (N-terminus longer);
FT                   P56255|PCRA_BACST from Bacillus stearothermophilus (724
FT                   aa); Q10213|YAY5_SCHPO from Schizosaccharomyces pombe
FT                   (Fission yeast) (887 aa), FASTA scores: opt: 927, E(): 0,
FT                   (33.5% identity in 659 aa overlap); etc. Also similar to
FT                   several other UvrD-like proteins in Mycobacterium
FT                   tuberculosis e.g. Rv3201c, Rv3198c, Rv3202c. Contains
FT                   PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO
FT                   THE UVRD SUBFAMILY OF HELICASES. Note that previously known
FT                   as uvrD."
FT                   /db_xref="GOA:P0A5A3"
FT                   /db_xref="HSSP:1PJR"
FT                   /db_xref="InterPro:IPR014016"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5A3"
FT                   /protein_id="CAE55341.1"
FT                   /translation="MSVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGAG
FT                   SGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAAEMRERVVGLVGEKARYMWVSTFH
FT                   STCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAISNL
FT                   KNELIDPHQALAGLTEDSDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVLQAFP
FT                   QIAQYYRRRFRHVLVDEYQDTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQSIYAF
FT                   RGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSVIARNAGRREKRLWTDAGAG
FT                   ELIVGYVADNEHDEARFVAEEIDALAEGSEITYNDVAVFYRTNNSSRSLEEVLIRAGIP
FT                   YKVVGGVRFYERKEIRDIVAYLRVLDNPGDAVSLRRILNTPRRGIGDRAEACVAVYAEN
FT                   TGVGFGDALVAAAQGKVPMLNTRAEKAIAGFVEMFDELRGRLDDDLGELVEAVLERTGY
FT                   RRELEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGPDDEDVPDTGVLADFLERV
FT                   SLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRALDNPTELSEER
FT                   RLAYVGITRARQRLYVSRAIVRSSWGQPMLNPESRFLREIPQELIDWRRTAPKPSFSAP
FT                   VSGAGRFGSARPSPTRSGASRRPLLVLQVGDRVTHDKYGLGRVEEVSGVGESAMSLIDF
FT                   GSSGRVKLMHNHAPVTKL"
FT   misc_feature    24596..24619
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   CDS             complement(26869..27867)
FT                   /transl_table=11
FT                   /locus_tag="Rv0950c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0950c, (MTCY10D7.24), len: 332 aa. Conserved
FT                   hypothetical protein, highly similar to
FT                   AL035500|MLCL373.02c|T45433 hypothetical protein from
FT                   Mycobacterium leprae (343 aa), FASTA scores: opt: 1500,
FT                   E(): 0, (71.0% identity in 331 aa overlap). C-terminus
FT                   highly similar to part of various proteins e.g. C-terminal
FT                   part of NP_441943.1|NC_000911|NlpD lipoprotein from
FT                   Synechocystis sp (715 aa); N-terminal part of
FT                   NP_066789.1|NC_002576 putative peptidase from Rhodococcus
FT                   equi (546 aa); C-terminal part of NP_212396.1|NC_001318
FT                   conserved hypothetical protein from Borrelia burgdorferi
FT                   (417 aa); C-terminal part of P33648|NLPD_ECOLI|nlpd
FT                   lipoprotein from Escherichia coli (379 aa), FASTA scores:
FT                   opt: 276, E(): 2e-10, (29.9% identity in 234 aa overlap);
FT                   etc."
FT                   /db_xref="GOA:P71560"
FT                   /db_xref="InterPro:IPR016047"
FT                   /db_xref="UniProtKB/TrEMBL:P71560"
FT                   /protein_id="CAB02000.1"
FT                   /translation="MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELDD
FT                   LDLGDDCVFDYEAQLLAAPELDDLDDADDLAPEWLVAPTVVLTPEVTPVSRRVGQHRKQ
FT                   PIGAARGRLLISAMAAGAAAAAAHTAIQQSETPRTETVLTAHASALNEGSGSNPPRGVQ
FT                   VIAAQPAASAAVHNAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLH
FT                   AGIDLANAIGTPIYAVSDGVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLVSVGER
FT                   VMAGDQIATMGSRGFSTGPHLHFEVLLGGTERVDPVPWLAKRGLSVGNYTG"
FT   CDS             28177..29340
FT                   /transl_table=11
FT                   /gene="sucC"
FT                   /locus_tag="Rv0951"
FT                   /product="PROBABLE SUCCINYL-CoA SYNTHETASE (BETA CHAIN)
FT                   SUCC (SCS-BETA)"
FT                   /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE [CATALYTIC
FT                   ACTIVITY: ATP + succinate + CoA = ADP + succinyl-CoA +
FT                   phosphate]."
FT                   /EC_number="6.2.1.5"
FT                   /note="Rv0951, (MTCY10D7.23c), len: 387 aa. Probable sucC,
FT                   succinyl-CoA synthetase, beta chain (EC 6.2.1.5),
FT                   equivalent to AL035500|MLCL373_3|NP_301241.1|NC_002677
FT                   succinyl-CoA synthase [beta] chain from Mycobacterium
FT                   leprae (393 aa), FASTA score: (86.7% identity in 391 aa
FT                   overlap). Also highly similar to others e.g.
FT                   AB92671.1|AL356832 succinyl-CoA synthetase beta chain from
FT                   Streptomyces coelicolor (394 aa); P25126|SUCC_THEFL
FT                   SUCCINYL-CoA SYNTHETASE BETA CHAIN from Thermus aquaticus
FT                   (378 aa); P07460|SUCC_ECOLI succinyl-CoA synthetase beta
FT                   chain from Escherichia coli (388 aa), FASTA scores: opt:
FT                   933, E(): 0, (41.0% identity in 390 aa overlap); etc."
FT                   /db_xref="GOA:P71559"
FT                   /db_xref="HSSP:1JKJ"
FT                   /db_xref="InterPro:IPR016102"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71559"
FT                   /protein_id="CAB01999.1"
FT                   /translation="MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVK
FT                   AQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEYYLSF
FT                   LLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGHLPA
FT                   EVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHA
FT                   EFEDRAATDPLELKAKEHDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHGGVKPA
FT                   NFLDIGGGASAEVMAAGLDVVLGDQQVKSVFVNVFGGITSCDAVATGIVKALGMLGDEA
FT                   NKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA"
FT   CDS             29353..30264
FT                   /transl_table=11
FT                   /gene="sucD"
FT                   /locus_tag="Rv0952"
FT                   /product="PROBABLE SUCCINYL-CoA SYNTHETASE (ALPHA CHAIN)
FT                   SUCD (SCS-ALPHA)"
FT                   /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE [CATALYTIC
FT                   ACTIVITY: ATP + succinate + CoA = ADP + succinyl-CoA +
FT                   phosphate]."
FT                   /EC_number="6.2.1.5"
FT                   /note="Rv0952, (MTCY10D7.22c), len: 303 aa. Probable sucD,
FT                   succinyl-CoA synthetase, alpha chain (EC 6.2.1.5),
FT                   equivalent to AL035500|MLCL373_4|NP_301242.1|NC_002677
FT                   succinyl-CoA synthase [alpha] chain from Mycobacterium
FT                   leprae (300 aa), FASTA score: (86.3% identity in 300 aa
FT                   overlap). Also highly similar to others e.g.
FT                   CAB92672.1|AL356832 from Streptomyces coelicolor (294 aa);
FT                   P53591|SUCD_COXBU from Escherichia coli (288 aa), FASTA
FT                   scores: opt: 855, E(): 0, (53.8% identity in 286 aa
FT                   overlap); etc. Contains PS00399 ATP-citrate lyase and
FT                   succinyl-CoA ligases active site, and PS00017
FT                   ATP/GTP-binding site motif A (P-loop)."
FT                   /db_xref="GOA:P71558"
FT                   /db_xref="HSSP:1JKJ"
FT                   /db_xref="InterPro:IPR016102"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71558"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB01998.1"
FT                   /translation="MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNAR
FT                   KAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPL
FT                   LVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIG
FT                   LVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEI
FT                   GGDAEERAADFIKTNVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAA
FT                   GVKVGKTPSATAALAREILLSL"
FT   misc_feature    30121..30138
FT                   /note="PS00399 ATP-citrate lyase and succinyl-CoA ligases
FT                   active site"
FT   misc_feature    30193..30216
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   CDS             complement(30327..31175)
FT                   /transl_table=11
FT                   /locus_tag="Rv0953c"
FT                   /product="POSSIBLE OXIDOREDUCTASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv0953c, (MTCY10D7.21), len: 282 aa. Possible
FT                   oxidoreductase (EC 1.-.-.-), equivalent to
FT                   CAA48222.1|X68102 hypothetical protein from Mycobacterium
FT                   avium subsp. paratuberculosis (166 aa). Similar to several
FT                   hypothetical proteins and oxidoreductases e.g.
FT                   AAK38097.1|AF323606_3|AF323606 putative F420-dependent
FT                   dehydrogenase from Rhodococcus erythropolis (295 aa);
FT                   NP_070025.1|NC_000917
FT                   N5,N10-methylenetetrahydromethanopterin reductase (mer-2)
FT                   from Archaeoglobus fulgidus (348 aa); etc. Also similar to
FT                   several hypothetical proteins and oxidoreductases from
FT                   Mycobacterium tuberculosis e.g.
FT                   Rv2161c|O06216|Z95388|MTCY270.07 (288 aa), FASTA scores:
FT                   opt: 633, E(): 0, (40.4% identity in 277 aa overlap),
FT                   Rv3079c (275 aa), Rv0791c (347 aa), etc. Contains PS00201
FT                   Flavodoxin signature."
FT                   /db_xref="InterPro:IPR016048"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64769"
FT                   /protein_id="CAB01997.1"
FT                   /translation="MHYGLVLFTSDRGITPAAAARLAESHGFRTFYVPEHTHIPVKRQA
FT                   AHPTTGDASLPDDRYMRTLDPWVSLGAASAVTSRIRLATAVALPVEHDPITLAKSIATL
FT                   DHLSHGRVSVGVGFGWNTDELVDHGVPPGRRRTMLREYLEAMRALWTQEEACYDGEFVK
FT                   FGPSWAWPKPVQPHIPVLVGAAGTEKNFKWIARSADGWITTPRDVDIDEPVKLLQDIWA
FT                   AAGRDGLPQIVALDVKPVPDKLARWAELGVTEVLFGMPDRSADDAAAYVERLAAKLACC
FT                   V"
FT   misc_feature    complement(31110..31160)
FT                   /note="PS00201 Flavodoxin signature"
FT   CDS             31340..32251
FT                   /transl_table=11
FT                   /locus_tag="Rv0954"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0954, (MTCY10D7.20c), len: 303 aa. Probable
FT                   conserved transmembrane protein, highly similar to
FT                   34KD_MYCPA|Q04959 34 kDa antigenic protein from
FT                   Mycobacterium paratuberculosis (298 aa), FASTA scores: opt:
FT                   1023, E(): 7.2e-36, (59.3% identity in 305 aa overlap);
FT                   AAC69251.1|U82111 34 kDa antigen precursor from
FT                   Mycobacterium leprae (336 aa); and AL035500|MLCL373.06
FT                   hypothetical membrane protein from Mycobacterium leprae
FT                   (297 aa), FASTA score: (55.6% identity in 315 aa overlap)."
FT                   /db_xref="GOA:P65637"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65637"
FT                   /protein_id="CAB01996.1"
FT                   /translation="MTYSPGNPGYPQAQPAGSYGGVTPSFAHADEGASKLPMYLNIAVA
FT                   VLGLAAYFASFGPMFTLSTELGGGDGAVSGDTGLPVGVALLAALLAGVALVPKAKSHVT
FT                   VVAVLGVLGVFLMVSATFNKPSAYSTGWALWVVLAFIVFQAVAAVLALLVETGAITAPA
FT                   PRPKFDPYGQYGRYGQYGQYGVQPGGYYGQQGAQQAAGLQSPGPQQSPQPPGYGSQYGG
FT                   YSSSPSQSGSGYTAQPPAQPPAQSGSQQSHQGPSTPPTGFPSFSPPPPVSAGTGSQAGS
FT                   APVNYSNPSGGEQSSSPGGAPV"
FT   CDS             32291..33658
FT                   /transl_table=11
FT                   /locus_tag="Rv0955"
FT                   /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0955, (MTCY10D7.19c), len: 455 aa. Probable
FT                   conserved integral membrane protein, highly similar to
FT                   AL035500|MLCL373_6 putative membrane protein from
FT                   Mycobacterium leprae (430 aa), FASTA score: (75.9% identity
FT                   in 419 aa overlap); and AAL05878.1|AF411607_2|AF411607
FT                   unknown protein from Mycobacterium avium subsp.
FT                   paratuberculosis (409 aa)."
FT                   /db_xref="GOA:P64771"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64771"
FT                   /protein_id="CAB01995.1"
FT                   /translation="MNRVSASADDRAAGARPARDLVRVAFGPGVVALGIIAAVTLLQLL
FT                   IANSDMTGAWGAIASMWLGVHLVPISIGGRALGVMPLLPVLLMVWATARSTARATSPQS
FT                   SGLVVRWVVASALGGPLLMAAIALAVIHDASSVVTELQTPSALRAFTSVLVVHSVGAAT
FT                   GVWSRVGRRALAATALPDWLHDSMRAAAAGVLALLGLSGVVTAGSLVVHWATMQELYGI
FT                   TDSIFGQFSLTVLSVLYAPNVIVGTSAIAVGSSAHIGFATFSSFAVLGGDIPALPILAA
FT                   APTPPLGPAWVALLIVGASSGVAVGQQCARRALPFVAAMAKLLVAAVAGALVMAVLGYG
FT                   GGGRLGNFGDVGVDEGALVLGVLFWFTFVGWVTVVIAGGISRRPKRLRPAPPVELDADE
FT                   SSPPVDMFDGAASEQPPASVAEDVPPSHDDIANGLKAPTADDEALPLSDEPPPRAD"
FT   CDS             33774..34421
FT                   /transl_table=11
FT                   /gene="purN"
FT                   /locus_tag="Rv0956"
FT                   /product="PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE
FT                   FORMYLTRANSFERASE PURN (GART) (GAR TRANSFORMYLASE)
FT                   (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE)"
FT                   /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE
FT                   THIRD STEP) [CATALYTIC ACTIVITY: 10-FORMYLTETRAHYDROFOLATE
FT                   + 5'-PHOSPHORIBOSYLGLYCINAMIDE = TETRAHYDROFOLATE +
FT                   5'-PHOSPHORIBOSYL-N-FORMYLGLYCINAMIDE]."
FT                   /EC_number="2.1.2.2"
FT                   /note="Rv0956, (MTCY10D7.18c), len: 215 aa. Probable purN,
FT                   5'-phosphoribosylglycinamide formyltransferase (EC
FT                   2.1.2.2), equivalent to AAF05726.1|AF191543_1|AF191543|PurN
FT                   phosphoribosylglycinamide formyltransferase from
FT                   Mycobacterium avium subsp. paratuberculosis (209 aa); and
FT                   AL035500|MLCL373_7 from Mycobacterium leprae (215 aa),
FT                   FASTA score: (79.4% identity in 214 aa overlap). Also
FT                   highly similar to others e.g. BAA89443.1|AB003159 from
FT                   Corynebacterium ammoniagenes (199 aa);
FT                   NP_241498.1|NC_002570 from Bacillus halodurans (188 aa);
FT                   P08179|PUR3_ECOLI|B2500 from Escherichia coli strain K12
FT                   (212 aa), FASTA scores: opt: 380, E(): 2.4e-18, (36.6%
FT                   identity in 183 aa overlap); C-terminus of
FT                   P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN
FT                   ADENOSINE-3 from Drosophila pseudoobscura (Fruit fly) (1364
FT                   aa); etc."
FT                   /db_xref="GOA:P71554"
FT                   /db_xref="InterPro:IPR004607"
FT                   /db_xref="PDB:3DA8"
FT                   /db_xref="UniProtKB/TrEMBL:P71554"
FT                   /protein_id="CAB01994.1"
FT                   /translation="MQEPLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAVG
FT                   VDRECRAAEIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRILGP
FT                   QFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILAQQP
FT                   VPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRTATMGRKVTIG"
FT   CDS             34418..35989
FT                   /transl_table=11
FT                   /gene="purH"
FT                   /locus_tag="Rv0957"
FT                   /product="PROBABLE BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN
FT                   PURH: PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE
FT                   FORMYLTRANSFERASE (AICAR TRANSFORMYLASE)
FT                   (5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE-4-CARBOXAMIDE
FT                   FORMYLTRANSFERASE) + INOSINEMONOPHOSPHATE CYCLOHYDROLASE
FT                   (IMP CYCLOHYDROLASE) (INOSINICASE) (IMP SYNTHETASE) (ATIC)"
FT                   /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE
FT                   NINTH AND TENTH STEPS) [CATALYTIC ACTIVITY 1:
FT                   10-formyltetrahydrofolate +
FT                   5'-phosphoribosyl-5-amino-4-imidazolecarboxamide =
FT                   tetrahydrofolate +
FT                   5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide]
FT                   [CATALYTIC ACTIVITY 2: IMP + H2O =
FT                   5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide]."
FT                   /EC_number="2.1.2.3"
FT                   /EC_number="3.5.4.10"
FT                   /note="Rv0957, (MTCY10D7.17c), len: 523 aa. Probable purH,
FT                   bifunctional purine biosynthesis protein including
FT                   5'-phosphoribosyl-5-aminoimidazole-4-carboxamide
FT                   formyltransferase (EC 2.1.2.3) and inosine-monophosphate
FT                   (IMP) cyclohydrolase (EC 3.5.4.10), equivalent to
FT                   AL035500|MLCL373_8 putative
FT                   phosphoribosylaminoimidazolecarboxamide formyltransferase
FT                   from Mycobacterium leprae (527 aa), FASTA score: (88.1%
FT                   identity in 520 aa overlap); and
FT                   AF05727.1|AF191543_2|AF191543|PurH from Mycobacterium avium
FT                   subsp. paratuberculosis (527 aa). Also highly similar to
FT                   others e.g. CAB92677.1|AL356832 bifunctional purine
FT                   biosynthesis protein from Streptomyces coelicolor (523 aa);
FT                   NP_388534.1|NC_000964 phosphoribosylaminoimidazole carboxy
FT                   formyl formyltransferase + inosine-monophosphate
FT                   cyclohydrolase from Bacillus subtilis (512 aa);
FT                   P15639|PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide
FT                   formyltransferase from Escherichia coli (529 aa), FASTA
FT                   scores: opt: 1147, E(): 0, (44.8% identity in 533 aa
FT                   overlap); etc. BELONGS TO THE PURH FAMILY."
FT                   /db_xref="GOA:P67541"
FT                   /db_xref="HSSP:1G8M"
FT                   /db_xref="InterPro:IPR011607"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67541"
FT                   /protein_id="CAB01993.1"
FT                   /translation="MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAK
FT                   TIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFE
FT                   LVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAA
FT                   LRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAM
FT                   LRYGENPHQQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAI
FT                   IKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIV
FT                   APGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWT
FT                   LATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERG
FT                   GERVRGAVAASDAFFPFPDGLETLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTG
FT                   ARHFAH"
FT   CDS             36096..37475
FT                   /transl_table=11
FT                   /locus_tag="Rv0958"
FT                   /product="POSSIBLE MAGNESIUM CHELATASE"
FT                   /function="CHELATION, INTRODUCING A MAGNESIUM ION INTO
FT                   SPECIFIC SUBSTRATE."
FT                   /EC_number="4.99.1.-"
FT                   /note="Rv0958, (MTCY10D7.16c), len: 459 aa. Possible
FT                   magnesium chelatase (EC 4.99.1.-), similar to others
FT                   (especially in N-terminal parts) e.g.
FT                   NP_296313.1|NC_001263|AE002088_10 putative magnesium
FT                   protoporphyrin chelatase from Deinococcus radiodurans (487
FT                   aa), FASTA scores: opt: 1148, E(): 0, (42.4% identity in
FT                   450 aa overlap); Q44498|CHLI_ANAVA MAGNESIUM-CHELATASE
FT                   SUBUNIT CHLI from Anabaena variabilis (338 aa); T31460
FT                   probable magnesium chelatase (EC 4.99.1.-) chain I bchI
FT                   from Heliobacillus mobilis (363 aa); etc. Contains PS00017
FT                   ATP/GTP-binding site motif A (P-loop)."
FT                   /db_xref="GOA:P71552"
FT                   /db_xref="UniProtKB/TrEMBL:P71552"
FT                   /protein_id="CAB01992.1"
FT                   /translation="MSPSNLPRTVGELRAAGHRERGVKQEIRENLLTALADGDNVWPGI
FT                   LGFDDTVIPQVERALIAGHDFVLLGERGQGKTRLLRALAGLLDEWTPVIAGAELGEHPY
FT                   TPITPESIRRAAQLGDDLPVAWKHRSERYTEKLATPDTSVADLVGDVDPIKVAEGRSLG
FT                   DPETIAYGLIPRAHRGIVAVNELPDLAERIQVSMLNVMEERDIQVRGYTLRLPLDVLVV
FT                   ASANPEDYTNRGRIITPIKDRFGAEIRTHYPLELEAEMGVIVQEAHLSAQVSDYLMQVL
FT                   ARFARYLRESRSIDQRSGVSARFAIAAAETVAAAARHRGAVLGETDPVARVVDLGTVID
FT                   VLRGKLEFESGEEGREQAVLEHLLRRATADTASRVLGGIDVGSLVTAVEGGSAVTTGER
FT                   VSAKDVLAAVPGLPVVDRIARKLGAESEGERAAALELALEALYLAKRVDKVCGEGQTVY
FT                   G"
FT   misc_feature    36303..36326
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   CDS             37468..39486
FT                   /transl_table=11
FT                   /locus_tag="Rv0959"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0959, (MTCY10D7.15c), len: 672 aa. Conserved
FT                   hypothetical protein, similar to AE002069|AE002069_12
FT                   hypothetical protein from Deinococcus radiodurans (403 aa),
FT                   FASTA scores: opt: 395, E(): 1.3e-15, (26.8% identity in
FT                   426 aa overlap). Contains a single copy at the N-terminus
FT                   of a short repeat found three times in the M. tuberculosis
FT                   ORF O33341|MTV003.05c|AL008883."
FT                   /db_xref="InterPro:IPR002035"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5D7"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB01991.1"
FT                   /translation="MAKSDGDDPLRPASPRLRSSRRHSLRYSAYTGGPDPLAPPVDLRD
FT                   ALEQIGQDVMAGASPRRALSELLRRGTRNLTGADRLAAEVNRRRRELLRRNNLDGTLQE
FT                   IKKLLDEAVLAERKELARALDDDARFAELQLDALPASPAKAVQELAEYRWRSGQAREKY
FT                   EQIKDLLGRELLDQRFAGMKQALAGATDDDRRRVTEMLDDLNDLLDKHARGEDTQRDFD
FT                   EFMTKHGEFFPENPRNVEELLDSLAKRAAAAQRFRNSLSQEQRDELDALAQQAFGSPAL
FT                   MRALDRLDAHLQAARPGEDWTGSQQFSGDNPFGMGEGTQALADIAELEQLAEQLSQSYP
FT                   GASMDDVDLDALARQLGDQAAVDARTLAELERALVNQGFLDRGSDGQWRLSPKAMRRLG
FT                   ETALRDVAQQLSGRHGERDHRRAGAAGELTGATRPWQFGDTEPWHVARTLTNAVLRQAA
FT                   AVHDRIRITVEDVEVAETETRTQAAVALLVDTSFSMVMENRWLPMKRTALALHHLVCTR
FT                   FRSDALQIIAFGRYARTVTAAELTGLAGVYEQGTNLHHALALAGRHLRRHAGAQPVVLV
FT                   VTDGEPTAHLEDFDGDGTSVFFDYPPHPRTIAHTVRGFDDMARLGAQVTIFRLGSDPGL
FT                   ARFIDQVARRVQGRVVVPDLDGLGAAVVGDYLRFRRR"
FT   CDS             39758..40141
FT                   /transl_table=11
FT                   /locus_tag="Rv0960"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0960, (MTCY10D7.14c), len: 127 aa. Conserved
FT                   hypothetical protein, similar to other Mycobacterium
FT                   tuberculosis hypothetical proteins e.g. Rv0065|MTV030.08
FT                   (133 aa), FASTA scores: E(): 1.5e-14, (38.3% identity in
FT                   128 aa overlap), Rv1720c (129 aa), and Rv0549c (137 aa)."
FT                   /db_xref="InterPro:IPR002716"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64773"
FT                   /protein_id="CAB01990.1"
FT                   /translation="MIVVDASAALAALLNDGQARQLIAAERLHVPHLVDSEIASGLRRL
FT                   AQRDRLGAADGRRALQTWRRLAVTRYPVVGLFERIWEIRANLSAYDASYVALAEALNCA
FT                   LVTADLRLSDTGQAQCPITVVPR"
FT   CDS             40287..40634
FT                   /transl_table=11
FT                   /locus_tag="Rv0961"
FT                   /product="PROBABLE INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0961, (MTCY10D7.13c), len: 115 aa. Probable
FT                   integral membrane protein."
FT                   /db_xref="GOA:P64775"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64775"
FT                   /protein_id="CAB01989.1"
FT                   /translation="MRVPSQWMISSRVTVAWNIVGYLVYAALAFVGGFAVWFSLFFAMA
FT                   TDGCHDSACDASYHVFPAMVTMWIGVGAVLLLTLVVMVRNSSRGNVVIGWPFVGLLALG
FT                   LVYVAADAVLH"
FT   CDS             complement(40653..41327)
FT                   /transl_table=11
FT                   /gene="lprP"
FT                   /locus_tag="Rv0962c"
FT                   /product="POSSIBLE LIPOPROTEIN LPRP"
FT                   /function="UNKNOWN"
FT                   /note="Rv0962c, (MTCY10D7.12), len: 224 aa. Possible lprP,
FT                   lipoprotein. Contains possible N-terminal signal sequence
FT                   and appropriately positioned PS00013 Prokaryotic membrane
FT                   lipoprotein lipid attachment site."
FT                   /db_xref="GOA:P71548"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71548"
FT                   /protein_id="CAB01988.1"
FT                   /translation="MKRTSRSLTAALLGIAALLAGCIKPNTFDPYANPGRGELDRRQKI
FT                   VNGRPDLETVQQQLANLDATIRAMIAKYSPQTRFSTGVTVSHLTNGCNDPFTRTIGRQE
FT                   ASELFFGRPAPTPQQWLQIVTELAPVFKAAGFRPNNSVPGDPPQPLGAPNYSQIRDDGV
FT                   TINLVNGDNRGPLGYSYNTGCHPPAAWRTAPPPLNMRPANDPDVHYPYLYGSPGGRTRD
FT                   AY"
FT   CDS             complement(41510..42310)
FT                   /transl_table=11
FT                   /locus_tag="Rv0963c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0963c, (MTCCY10D7.11), len: 266 aa. Conserved
FT                   hypothetical protein, similar in part to other CONSERVED
FT                   HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g.
FT                   Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: E(): 1.2e-23,
FT                   (39.0% identity in 254 aa overlap); Rv2542 (403 aa); Rv2079
FT                   (656 aa). Also similar in part to AL133423|SC4A7_3
FT                   HYPOTHETICAL SECRETED PROTEIN from Streptomyces coelicolor
FT                   (406 aa), FASTA scores: opt: 231, E(): 6.8e-07, (31.4%
FT                   identity in 204 aa overlap); and SCH10.21c|T36533
FT                   hypothetical protein from Streptomyces coelicolor (329
FT                   aa)."
FT                   /db_xref="InterPro:IPR010427"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64777"
FT                   /protein_id="CAB02008.1"
FT                   /translation="MLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTSL
FT                   ILLDTASDPRKVLAAVGVGDVDNAERVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAAEL
FT                   RERAGWPNYDAVASIAWLGYDAPDGLKDVMHDWSARDAAGPLNRFDKGLAATTNVSDQH
FT                   ITAFGHSYGSLVTSLALQQGAPVSDVVLYGSPGTELTHASQLGVEPGHAFYMIGVNDHV
FT                   ANTIPEFGAFGSAPQDVPGMTQLSVNTGLAPGPLLGDGQLHERA"
FT   CDS             complement(42409..42891)
FT                   /transl_table=11
FT                   /locus_tag="Rv0964c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0964c, (MTCY10D7.10), len: 160 aa. Hypothetical
FT                   unknown protein. Equivalent to AAK45241.1 from
FT                   Mycobacterium tuberculosis strain CDC1551 (138 aa) but
FT                   longer 22 aa."
FT                   /db_xref="UniProtKB/Swiss-Prot:P71546"
FT                   /protein_id="CAB01987.1"
FT                   /translation="MGLLGFGGAAAEAAQVATHHTTVLLDHHAGACEAVARAAEKAAEE
FT                   VAAIKMRLQVIRDAAREHHLTIAYATGTALPPPDLSSYSPADQQAILNTAIRRASNVCW
FT                   PTPRPPMRIWPRRFDAPPGPCRASRSMPNSAMRHPQCRRCRRRTATLRRSSGGGIR"
FT   CDS             complement(42991..43410)
FT                   /transl_table=11
FT                   /locus_tag="Rv0965c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0965c, (MTCY10D7.09), len: 139 aa. Conserved
FT                   hypothetical protein, showing weak similarity with
FT                   Rv2798c|MTCY16B7.45 CONSERVED HYPOTHETICAL PROTEIN from
FT                   Mycobacterium tuberculosis (108 aa), FASTA scores: E():
FT                   5.6e-12, (38.9% identity in 90 aa overlap). Equivalent to
FT                   AAK45242.1 from Mycobacterium tuberculosis strain CDC1551
FT                   (146 aa) but shorter 7 aa."
FT                   /db_xref="UniProtKB/Swiss-Prot:P71545"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB01986.1"
FT                   /translation="MRVNRPQCARVPYSAESLVRVEASWYGRTLRAIPEVLSQVGYQQA
FT                   DHGESLLTSHHCCLGAAEGARPGWVGSSAGALSGLLDSWAEASTAHAARIGDHSYGMHL
FT                   AAVGFAEMEEHNAAALAAVYPTGGGSARCDGVDVS"
FT   CDS             complement(43446..44048)
FT                   /transl_table=11
FT                   /locus_tag="Rv0966c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0966c, (MTCY10D7.08), len: 200 aa. Conserved
FT                   hypothetical protein, equivalent to AL035500|MLCL373_12
FT                   CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae
FT                   (200 aa), FASTA scores: opt: 1080, E(): 0, (79.5% identity
FT                   in 200 aa overlap). Also highly similar to
FT                   SCE6.30c|CAB88834.1|AL353832 hypothetical protein from
FT                   Streptomyces coelicolor (277 aa). Some similarity to
FT                   Rv2862c|MTV007.08 CONSERVED HYPOTHETICAL PROTEIN from
FT                   Mycobacterium tuberculosis (194 aa), FASTA scores: E():
FT                   3.1e-06, (31.5% identity in 184 aa overlap). Equivalent to
FT                   AAK45243.1 from Mycobacterium tuberculosis strain CDC1551
FT                   (230 aa) but shorter 30 aa. Note that Rv0966c has been
FT                   shortened since first entry."
FT                   /db_xref="InterPro:IPR012551"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71544"
FT                   /protein_id="CAB01985.2"
FT                   /translation="MSNSAQRDARNSRDESARASDTDRIQIAQLLAYAAEQGRLQLTDY
FT                   EDRLARAYAATTYQELDRLRADLPGAAIGPRRGGECNPAPSTLLLALLGGFERRGRWNV
FT                   PKKLTTFTLWGSGVLDLRYADFTSTEVDIRAYSIMGAQTILLPPEVNVEIHGHRVMGGF
FT                   DRKVVGEGTRGVPTVRIRGFSLWGDVGIKRKPRKPRK"
FT   CDS             44188..44547
FT                   /transl_table=11
FT                   /locus_tag="Rv0967"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0967, (MTCY10D7.07c), len: 119 aa. Conserved
FT                   hypothetical protein, similar to hypothetical proteins from
FT                   several organisms e.g. AE002074|AE002074_11 from
FT                   Deinococcus radiodurans (102 aa), FASTA scores: opt: 233,
FT                   E(): 8.6e-10, (47.0% identity in 83 aa overlap);
FT                   O32222|Z99121|YVGZ from Bacillus subtilis (101 aa), FASTA
FT                   scores: opt:228, E(): 3.2e-15, (38.0% identity in 92 aa
FT                   overlap); etc. Also similar to Mycobacterium tuberculosis
FT                   hypothetical proteins Rv0190, and Rv1766."
FT                   /db_xref="GOA:P71543"
FT                   /db_xref="InterPro:IPR003735"
FT                   /db_xref="PDB:2HH7"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71543"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB02009.1"
FT                   /translation="MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISA
FT                   VQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAV
FT                   GESATEEPMPDASNM"
FT   CDS             44604..44900
FT                   /transl_table=11
FT                   /locus_tag="Rv0968"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved
FT                   hypothetical protein, similar to NP_301579.1|NC_002677
FT                   conserved hypothetical protein from Mycobacterium leprae
FT                   (92 aa). Also highly similar to CONSERVED HYPOTHETICAL
FT                   PROTEINS from Mycobacterium tuberculosis e.g. Rv3269 (93
FT                   aa), FASTA score: (51.1% identity in 94 aa overlap); and
FT                   Rv1993c (90 aa)."
FT                   /db_xref="InterPro:IPR009963"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64779"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB01984.1"
FT                   /translation="MVWHGFLAKAVPTVVTGAVGVAAYEALRKMVVKAPLRAATVSVAA
FT                   WGIRLAREAERKAGESAEQARLMFADVLAEASERAGEEVPPLAVAGSDDGHDH"
FT   CDS             44956..47268
FT                   /transl_table=11
FT                   /gene="ctpV"
FT                   /locus_tag="Rv0969"
FT                   /product="PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE
FT                   CTPV"
FT                   /function="METAL CATION-TRANSPORTING ATPASE; POSSIBLY
FT                   CATALYZES THE TRANSPORT OF UNDETERMINATED METAL CATION WITH
FT                   HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O +
FT                   UNDETERMINATED METAL CATION(IN) = ADP + PHOSPHATE +
FT                   UNDETERMINATED METAL CATION(OUT)]."
FT                   /EC_number="3.6.3.-"
FT                   /note="Rv0969, (MTCY10D7.05c), len: 770 aa. Probable ctpV,
FT                   metal cation transporter P-type ATPase (transmembrane
FT                   protein) (EC 3.6.3.-) (see citation below), highly similar
FT                   (except in N-terminus) to others e.g. NP_391230.1|NC_000964
FT                   similar to heavy metal-transporting ATPase from Bacillus
FT                   subtilis (803 aa); P37279|ATCS_SYNP7|PACS
FT                   cation-transporting ATPase from Synechococcus sp. strain
FT                   PCC 7942 (Anacystis nidulans R2) (747 aa), FASTA scores:
FT                   opt: 1851, E(): 0, (52.1% identity in 664 aa overlap); etc.
FT                   Equivalent to AAK45246.1 from Mycobacterium tuberculosis
FT                   strain CDC1551 (792 aa) but shorter 22 aa. Contains PS00154
FT                   E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION
FT                   TRANSPORT ATPASES FAMILY (E1-E2 ATPASES)."
FT                   /db_xref="GOA:P77894"
FT                   /db_xref="InterPro:IPR001757"
FT                   /db_xref="UniProtKB/Swiss-Prot:P77894"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB01983.1"
FT                   /translation="MRVCVTGFNVDAVRAVAIEETVSQVTGVHAVHAYPRTASVVIWYS
FT                   PELGDTAAVLSAITKAQHVPAELVPARAPHSAGVRGVGVVRKITGGIRRMLSRPPGVDK
FT                   PLKASRCGGRPRGPVRGSASWPGEQNRRERRTWLPRVWLALPLGLLALGSSMFFGAYPW
FT                   AGWLAFAATLPVQFVAGWPILRGAVQQARALTSNMDTLIALGTLTAFVYSTYQLFAGGP
FT                   LFFDTSALIIAFVVLGRHLEARATGKASEAISKLLELGAKEATLLVDGQELLVPVDQVQ
FT                   VGDLVRVRPGEKIPVDGEVTDGRAAVDESMLTGESVPVEKTAGDRVAGATVNLDGLLTV
FT                   RATAVGADTALAQIVRLVEQAQGDKAPVQRLADRVSAVFVPAVIGVAVATFAGWTLIAA
FT                   NPVAGMTAAVAVLIIACPCALGLATPTAIMVGTGRGAELGILVKGGEVLEASKKIDTVV
FT                   FDKTGTLTRARMRVTDVIAGQRRQPDQVLRLAAAVESGSEHPIGAAIVAAAHERGLAIP
FT                   AANAFTAVAGHGVRAQVNGGPVVVGRRKLVDEQHLVLPDHLAAAAVEQEERGRTAVFVG
FT                   QDGQVVGVLAVADTVKDDAADVVGRLHAMGLQVAMITGDNARTAAAIAKQVGIEKVLAE
FT                   VLPQDKVAEVRRLQDQGRVVAMVGDGVNDAPALVQADLGIAIGTGTDVAIEASDITLMS
FT                   GRLDGVVRAIELSRQTLRTIYQNLGWAFGYNTAAIPLAALGALNPVVAGAAMGFSSVSV
FT                   VTNSLRLRRFGRDGRTA"
FT   misc_feature    46333..46353
FT                   /note="PS00154 E1-E2 ATPases phosphorylation site"
FT   CDS             47265..47897
FT                   /transl_table=11
FT                   /locus_tag="Rv0970"
FT                   /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0970, (MTCY10D7.04c), len: 210 aa. Probable
FT                   conserved integral membrane protein, equivalent to
FT                   NP_302348.1|NC_002677 probable integral membrane protein
FT                   from Mycobacterium leprae (210 aa)."
FT                   /db_xref="GOA:P64781"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64781"
FT                   /protein_id="CAB01982.1"
FT                   /translation="MIHDLMLRWVVTGLFVLTAAECGLAIIAKRRPWTLIVNHGLHFAM
FT                   AVAMAVMAWPWGARVPTTGPAVFFLLAAVWFGATAVVAVRGTATRGLYGYHGLMMLATA
FT                   WMYAAMNPRLLPVRSCTEYATEPDGSMPAMDMTAMNMPPNSGSPIWFSAVNWIGTVGFA
FT                   VAAVFWACRFVMERRQEATQSRLPGSIGQAMMAAGMAMLFFAMLFPV"
FT   CDS             complement(47988..48797)
FT                   /transl_table=11
FT                   /gene="echA7"
FT                   /locus_tag="Rv0971c"
FT                   /product="PROBABLE ENOYL-CoA HYDRATASE ECHA7 (ENOYL
FT                   HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)"
FT                   /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING
FT                   SPECIFIC COMPONENTS [CATALYTIC ACTIVITY:
FT                   (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]."
FT                   /EC_number="4.2.1.17"
FT                   /note="Rv0971c, (MTCY10D7.03), len: 269 aa. Probable echA7,
FT                   enoyl-CoA hydratase (EC 4.2.1.17), similar to many e.g.
FT                   CAB95895.1|AL359988 putative enoyl CoA hydratase from
FT                   Streptomyces coelicolor (247 aa); P24162|ECHH_RHOCA
FT                   enoyl-CoA hydratase from Rhodobacter capsulatus (257 aa),
FT                   FASTA scores: opt: 369, E(): 2.6e-15, (33.7% identity in
FT                   246 aa overlap); etc."
FT                   /db_xref="GOA:P71540"
FT                   /db_xref="HSSP:1MJ3"
FT                   /db_xref="InterPro:IPR001753"
FT                   /db_xref="UniProtKB/TrEMBL:P71540"
FT                   /protein_id="CAB02007.1"
FT                   /translation="MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLSA
FT                   AEADPAVRLVVLGHTGGTFCAGADLSEAGGGGGDPYRMAVARAREMTALLRAIVESPLP
FT                   VVGAINGHVRAGGFGLVGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPRAAA
FT                   RYYLTGEKFGAREAADIGLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTAAVLE
FT                   GFDRDAERLTEESARLFVSDEAREGMLAFLQKRPPRWVQPATMRAAD"
FT   CDS             complement(48797..49963)
FT                   /transl_table=11
FT                   /gene="fadE12"
FT                   /locus_tag="Rv0972c"
FT                   /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE12"
FT                   /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION."
FT                   /EC_number="1.3.99.-"
FT                   /note="Rv0972c, (MTCY10D7.02), len: 388 aa. Probable
FT                   fadE12, acyl-CoA dehydrogenase (EC 1.3.99.-), highly
FT                   similar to many e.g. CAB95893.1|AL359988 putative acyl CoA
FT                   dehydrogenase from Streptomyces coelicolor (382 aa);
FT                   P45857|ACDB_BACSU from Bacillus subtilis (379 aa), FASTA
FT                   scores: opt: 576, E(): 2.3e-26, (29.7% identity in 381 aa
FT                   overlap); etc."
FT                   /db_xref="GOA:P71539"
FT                   /db_xref="InterPro:IPR013764"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71539"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB02006.1"
FT                   /translation="MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSELW
FT                   AEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSPAINGTIIAKFG
FT                   TDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFISGID
FT                   QAQAVLVVGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSPERQFQVFLDDVRLP
FT                   ADALVGAEDAAIAQLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQ
FT                   GLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQ
FT                   SMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY"
FT   CDS             complement(49960..51963)
FT                   /transl_table=11
FT                   /gene="accA2"
FT                   /locus_tag="Rv0973c"
FT                   /standard_name="bccA"
FT                   /product="PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE
FT                   ALPHA CHAIN (ALPHA SUBUNIT) ACCA2: BIOTIN CARBOXYLASE +
FT                   BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)"
FT                   /function="THIS PROTEIN CARRIES TWO FUNCTIONS: BIOTIN
FT                   CARBOXYL CARRIER PROTEIN AND BIOTIN CARBOXYLTRANSFERASE.
FT                   INVOLVED IN THE FIRST STEP OF LONG-CHAIN FATTY ACID
FT                   SYNTHESIS [CATALYTIC ACTIVITY: ATP +
FT                   BIOTIN-CARBOXYL-CARRIER PROTEIN + CO(2) = ADP + PHOSPHATE +
FT                   CARBOXYBIOTIN-CARBOXYL-CARRIER PROTEIN]."
FT                   /EC_number="6.3.4.14"
FT                   /note="Rv0973c, (MTV044.01c, MTCY10D7.01), len: 667 aa.
FT                   Probable accA2 (alternate gene name: bccA),
FT                   acetyl-/propionyl-coenzyme A carboxylase (alpha subunit)
FT                   [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN
FT                   CARBOXYL CARRIER PROTEIN (BCCP)], highly similar to others
FT                   e.g. CAB95892.1|AL359988 putative acetyl/propionyl CoA
FT                   carboxylase alpha subunit from Streptomyces coelicolor (614
FT                   aa); NP_250702.1|NC_002516 probable acyl-CoA carboxylase
FT                   alpha chain from Pseudomonas aeruginosa (655 aa);
FT                   NP_420971.1|NC_002696 acetyl/propionyl-CoA carboxylase
FT                   alpha subunit from Caulobacter crescentus ( 654 aa);
FT                   NP_251581.1|NC_002516 probable biotin carboxylase/biotin
FT                   carboxyl carrier protein from Pseudomonas aeruginosa (661
FT                   aa); etc. Also highly similar to others from Mycobacterium
FT                   tuberculosis e.g.
FT                   Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 PROBABLE
FT                   ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA
FT                   SUBUNIT) (654 aa), FASTA scores, opt: 250, E(): 4e-09,
FT                   (28.6% identity in 182 aa overlap); and
FT                   Rv3285|MTCY71.25|ACCA3 (600 aa); Z83018|MTCY349_20 (1127
FT                   aa), FASTA scores: opt: 838, E(): 0, (40.2% identity in 500
FT                   aa overlap). Contains PS00867 Carbamoyl-phosphate synthase
FT                   subdomain signature 2 and PS00188 Biotin-requiring enzymes
FT                   attachment site."
FT                   /db_xref="GOA:P71538"
FT                   /db_xref="HSSP:1A6X"
FT                   /db_xref="InterPro:IPR013817"
FT                   /db_xref="UniProtKB/TrEMBL:P71538"
FT                   /protein_id="CAB02010.1"
FT                   /translation="MGITRVLVANRGEIARRVFATCRRLGLGTVAVYTDPDAAAPHVAE
FT                   ADARVRLPQTTDYLNAEAIIAAAQAAGADAVHPGYGFLSENAEFAAAVQEAGLTWVGPP
FT                   VDAVRAMGSKIESKKLMAAAGVPVLEELDPDAVTTAQLPVLVKASAGGGGRGMRVVHEL
FT                   SALPAEVEAARREAQSAFGDPTVFCERYLPTGHHVEVQVMADTHGTVWAVGERECSIQR
FT                   RHQKIIEEAPSPLVERVPGMRAKLFDAARLAASAIGYTGAGTVEFLADDSPGREGEFYF
FT                   LEMNTRLQVEHPVTEETTGLDLVELQLMIADCGRLDTEPPPAQGYSIEARLYAEDPAHG
FT                   WQPQAGVMHTIEVPGVRAQFDSLGQRTGIRLDSGIVDGSTVSIHYDPMLAKVVSYGATR
FT                   RQAALVLADALVRARLHGLRTNRELLVNVLRHPAFLDGATDTGFFDTHGMAELSTPLAD
FT                   TATLRLSAIAAALADAEHNRASAGVFSSIPSGWRNLASGYQVKTYRDDADTEHRVEYRF
FT                   TRTGLALPGDPVVQLVSADVDQVVLAQDGVAHGFTVARHGPDVYVDSARGPVHLVALSR
FT                   FPEPSSAVEQGSLVAPMPGNVIRIGAEVGDTVTAGQPLIWLEAMKMEHTIAAPADGVLT
FT                   HVSVNTGQQVEVGAILARVEAPQNGPAEGDSP"
FT   misc_feature    complement(50080..50133)
FT                   /note="PS00188 Biotin-requiring enzymes attachment site"
FT   misc_feature    complement(51100..51123)
FT                   /note="PS00867 Carbamoyl-phosphate synthase subdomain
FT                   signature 2"
FT   CDS             complement(51969..53558)
FT                   /transl_table=11
FT                   /gene="accD2"
FT                   /locus_tag="Rv0974c"
FT                   /product="PROBABLE ACETYL-/PROPIONYL-CoA CARBOXYLASE (BETA
FT                   SUBUNIT) ACCD2"
FT                   /function="INVOLVED IN FATTY ACID METABOLISM."
FT                   /EC_number="6.4.1.-"
FT                   /note="Rv0974c, (MTV044.02c), len: 529 aa. Probable accD2,
FT                   acetyl-/propionyl-CoA carboxylase (beta subunit) (EC
FT                   6.4.1.-), highly similar to many e.g. CAB95891.1|AL35998
FT                   putative acetyl/propionyl CoA carboxylase beta subunit from
FT                   Streptomyces coelicolor (532 aa); NP_250704.1|NC_002516
FT                   probable acyl-CoA carboxyltransferase beta chain from
FT                   Pseudomonas aeruginosa (535 aa); BAB16296.1|AB039884
FT                   acetyl-CoA carboxylase carboxyltransferase from Myxococcus
FT                   xanthus (538 aa); NP_420973.1|NC_002696 putative
FT                   propionyl-CoA carboxylase beta subunit from Caulobacter
FT                   crescentus (530 aa); etc. Also similar to other from
FT                   Mycobacterium tuberculosis: Rv2502c|ACCD1, Rv3799c|ACCD4,
FT                   etc. COULD BELONG TO THE ACCD/PCCB FAMILY. TBparse score is
FT                   0.875."
FT                   /db_xref="GOA:O86318"
FT                   /db_xref="HSSP:1ON9"
FT                   /db_xref="InterPro:IPR011762"
FT                   /db_xref="UniProtKB/TrEMBL:O86318"
FT                   /protein_id="CAB02011.1"
FT                   /translation="MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDR
FT                   HHARGNLTPRERIELLVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVAN
FT                   DPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDL
FT                   TRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDD
FT                   ESLGGAEMHARISGLADYFALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEEL
FT                   IGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGV
FT                   LFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTV
FT                   PHISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEAR
FT                   GQQVDEAADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGP
FT                   IKGTSNFGVFRM"
FT   CDS             complement(53561..54709)
FT                   /transl_table=11
FT                   /gene="fadE13"
FT                   /locus_tag="Rv0975c"
FT                   /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE13"
FT                   /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION."
FT                   /EC_number="1.3.99.-"
FT                   /note="Rv0975c, (MTV044.03c), len: 382 aa. Probable fadE13,
FT                   acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to
FT                   many e.g. T35427 probable acyl-CoA dehydrogenase from
FT                   Streptomyces coelicolor (382 aa); M74096|HUMACADL_1 Human
FT                   long chain acyl-CoA dehydrogenase from Homo sapiens (430
FT                   aa), FASTA scores: opt: 819, E(): 0, (37.0% identity in 376
FT                   aa overlap); etc. Also similar to others from Mycobacterium
FT                   tuberculosis e.g. fadE20|Z98209|MTCY154_4 (386 aa), FASTA
FT                   scores: (40.3% identity in 375 aa overlap). Contains
FT                   PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE
FT                   ACYL-COA DEHYDROGENASES FAMILY."
FT                   /db_xref="GOA:O86319"
FT                   /db_xref="HSSP:1JQI"
FT                   /db_xref="InterPro:IPR013786"
FT                   /db_xref="UniProtKB/TrEMBL:O86319"
FT                   /protein_id="CAB02012.1"
FT                   /translation="MNIWTTPERQQLRKTVRAFAEREILPHVDEWERIGELPRGLHRLA
FT                   GAAGLLGAGFPEAVGGGGGDGADPVIICEEMHQAGAPGGVYASLFTCGIAVPHMVASGD
FT                   ERLIATYVRPTLAGEKIGALAITEPGGGSDVGHLRTSAVRDGDHYVINGAKTYITSGVR
FT                   ADYVVTAVRTGGPGAAGVSLLVVEKDTPGFEVTRKLDKMGWRSSDTAELCYTDVAVPAT
FT                   NLVGAENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRPLISRQSV
FT                   QNTLAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTAVQAGEWVANQAVQLFG
FT                   GMGYMAESEVERQYRDMRILGIGGGTTEILTALAAKTLGYQS"
FT   misc_feature    complement(53642..53701)
FT                   /note="PS00073 Acyl-CoA dehydrogenases signature 2"
FT   CDS             complement(54706..56388)
FT                   /transl_table=11
FT                   /locus_tag="Rv0976c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0976c, (MTV044.04c), len: 560 aa. Conserved
FT                   hypothetical protein, highly similar to others e.g.
FT                   CAB95890.1|AL359988 conserved hypothetical protein from
FT                   Streptomyces coelicolor (558 aa); P_251576.1|NC_002516
FT                   hypothetical protein from Pseudomonas aeruginosa (600 aa);
FT                   etc. N-terminal part highly similar to AL035500|MLCL373_14
FT                   probable pseudogene from Mycobacterium leprae (163 aa),
FT                   FASTA score: (50.0% identity in 122 aa overlap). TBparse
FT                   score is 0.860."
FT                   /db_xref="InterPro:IPR010839"
FT                   /db_xref="UniProtKB/TrEMBL:O86320"
FT                   /protein_id="CAB02013.1"
FT                   /translation="MRIGNCSGFYGDRLSAMREMLTGGELDYLTGDYLAELTMLILGRD
FT                   RMKNPDRGYAKTFLAQLEDCLGLAHDRGVRIVTNAGGLNPAGLANAVRALAARLGIPAQ
FT                   VAHVEGDDLQPRAAELGLGTPLTANAYLGAWGIVDCFERGADVVVTGRVTDASVVVGAA
FT                   AAHFGWGRTDYHRLAGAVVAGHVIECGVQATGGNYAFFTEIGDLTHAGFPLAEIAADGS
FT                   SVITKHHGTGGLVSVDTITAQLLYEITGARYANPDVTARMDSVELSPDGPDRVRISGVI
FT                   GEPPPPTYKVSLNSIGGFRNAMTFVLTGLDIDAKADLVRRQLEAALTVKPAELQWTLAR
FT                   TDHPDADTEETASALLTCVARDPDPANVGRQFSSAAVELALASYPGFTATAPPGDGQVY
FT                   GVFTPGYVDAGKVAHIAVHADGTRTEIPCATETLELAPAHPPALPDPLPAGPTRRVPLG
FT                   LIAGARSGDKGGSANVGVWVRTDEQWRWLAHTLTVELLKELLPETAGLVVTRHVLPNLR
FT                   ALNFVIEAILGQGVAYQARFDPQAKGLGEWLRSRHVEIPETLL"
FT   CDS             56586..59357
FT                   /transl_table=11
FT                   /gene="PE_PGRS16"
FT                   /locus_tag="Rv0977"
FT                   /product="PE-PGRS FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0977, (MTV044.05), len: 923 aa. Member of the
FT                   Mycobacterium tuberculosis PE family, PGRS subfamily of
FT                   gly-rich proteins (see citation below), highly similar to
FT                   other PGRS-type sequences e.g. AL0091|MTV004_1 from
FT                   Mycobacterium tuberculosis (1125 aa), FASTA score: (45.4%
FT                   identity in 959 aa overlap); Z80225|MTCY441_4 from
FT                   Mycobacterium tuberculosis (778 aa), FASTA score: (51.5%
FT                   identity in 750 aa overlap); etc. TBparse score is 0.868."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FU3"
FT                   /protein_id="CAE55342.1"
FT                   /translation="MSFVVTAPPVLASAASDLGGIASMISEANAMAAVRTTALAPAAAD
FT                   EVSAAIAALFSSYARDYQTLSVQVTAFHVQFAQTLTNAGQLYAVVDVGNGVLLKTEQQV
FT                   LGVINAPTQTLVGRPLIGDGTHGAPGTGQNGGAGGILWGNGGNGGSGAPGQPGGRGGDA
FT                   GLFGHGGHGGVGGPGIAGAAGTAGLPGGNGANGGSGGIGGAGGAGGNGGLLFGNGGAGG
FT                   QGGSGGLGGSGGTGGAGMAAGPAGGTGGIGGIGGIGGAGGVGGHGSALFGHGGINGDGG
FT                   TGGMGGQGGAGGNGWAAEGITVGIGEQGGQGGDGGAGGAGGIGGSAGGIGGSQGAGGHG
FT                   GDGGQGGAGGSGGVGGGGAGAGGDGGAGGIGGTGGNGSIGGAAGNGGNGGRGGAGGMAT
FT                   AGSDGGNGGGGGNGGVGVGSAGGAGGTGGDGGAAGAGGAPGHGYFQQPAPQGLPIGTGG
FT                   TGGEGGAGGAGGDGGQGDIGFDGGRGGDGGPGGGGGAGGDGSGTFNAQANNGGDGGAGG
FT                   VGGAGGTGGTGGVGADGGRGGDSGRGGDGGNAGHGGAAQFSGRGAYGGEGGSGGAGGNA
FT                   GGAGTGGTAGSGGAGGFGGNGADGGNGGNGGNGGFGGINGTFGTNGAGGTGGLGTLLGG
FT                   HNGNIGLNGATGGIGSTTLTNATVPLQLVNTTEPVVFISLNGGQMVPVLLDTGSTGLVM
FT                   DSQFLTQNFGPVIGTGTAGYAGGLTYNYNTYSTTVDFGNGLLTLPTSVNVVTSSSPGTL
FT                   GNFLSRSGAVGVLGIGPNNGFPGTSSIVTAMPGLLNNGVLIDESAGILQFGPNTLTGGI
FT                   TISGAPISTVAVQIDNGPLQQAPVMFDSGGINGTIPSALASLPSGGFVPAGTTISVYTS
FT                   DGQTLLYSYTTTATNTPFVTSGGVMNTGHVPFAQQPIYVSYSPTAIGTTTFN"
FT   CDS             complement(59574..60569)
FT                   /transl_table=11
FT                   /gene="PE_PGRS17"
FT                   /locus_tag="Rv0978c"
FT                   /product="PE-PGRS FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0978c, (MTV044.06c), len: 331 aa. Member of the
FT                   Mycobacterium tuberculosis PE family, PGRS subfamily of
FT                   gly-rich proteins (see citation below), highly similar to
FT                   others e.g. Z95387|MTCY1A10_19 from Mycobacterium
FT                   tuberculosis (461 aa), FASTA score: (73.6% identity in 277
FT                   aa overlap); etc. TBparse score is 0.861."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FU2"
FT                   /protein_id="CAE55343.1"
FT                   /translation="MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDE
FT                   VSTAIAALFGSHGQHYQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLDAI
FT                   NAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIG
FT                   NGGAGGTGGAVSLARAGTAGGAGRGPVGGIGGAGGVGGAGGAAGAVTTITHASFNDPHG
FT                   VAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVTNFDS
FT                   NTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS"
FT   CDS             complement(60883..61077)
FT                   /transl_table=11
FT                   /locus_tag="Rv0979c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0979c, (MTV044.07c), len: 64 aa (unlikely ORF).
FT                   Hypothetical unknown protein. Start codon changed since
FT                   first submission (-44 aa)."
FT                   /db_xref="UniProtKB/TrEMBL:O53892"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17578.2"
FT                   /translation="MGFRTQVGAATIASTMTWRIPVEDGPAQFRAGVGPGRDRQFTVVA
FT                   PMVVGLWDRNRRPGWQWPS"
FT   CDS             61099..61272
FT                   /transl_table=11
FT                   /gene="rpmF"
FT                   /locus_tag="Rv0979A"
FT                   /product="PROBABLE 50S RIBOSOMAL PROTEIN L32 RPMF"
FT                   /function="INVOLVED IN TRANSLATION MECHANISM."
FT                   /note="Rv0979A, len: 57 aa. Probable rpmF, 50S ribosomal
FT                   protein L32, similar to others e.g. rpmF|Q9RL50 PROBABLE
FT                   50S RIBOSOMAL PROTEIN from Streptomyces coelicolor (56 aa),
FT                   FASTA scores: E(): 5.1e-09, (63.45% identity in 52 aa
FT                   overlap); etc. BELONGS TO THE L32P FAMILY OF RIBOSOMAL
FT                   PROTEINS."
FT                   /db_xref="GOA:P0A5V8"
FT                   /db_xref="InterPro:IPR002677"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5V8"
FT                   /protein_id="CAE55344.1"
FT                   /translation="MAVPKRRKSRSNTRSRRSQWKAAKTELVGVTVAGHAHKVPRRLLK
FT                   AARLGLIDFDKR"
FT   CDS             complement(61291..62664)
FT                   /transl_table=11
FT                   /gene="PE_PGRS18"
FT                   /locus_tag="Rv0980c"
FT                   /product="PE-PGRS FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0980c, (MTV044.08c), len: 457 aa. Member of the
FT                   Mycobacterium tuberculosis PE family, PGRS subfamily of
FT                   gly-rich proteins (see Brennan & Delogu 2002), highly
FT                   similar to others e.g. Z95387|MTCY1A10_19 from
FT                   Mycobacterium tuberculosis (461 aa), FASTA score: (66.7%
FT                   identity in 405 aa overlap); Z95844|MTCY493_2 from
FT                   Mycobacterium tuberculosis (741 aa), FASTA score: (53.0%
FT                   identity in 394 aa overlap); etc."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FU0"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55345.1"
FT                   /translation="MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAHDE
FT                   VSTAIAALFGSHGQHYQAISAQVAAYQERFVLALSQASSTYAVAEAASATPLQNVLDAI
FT                   NAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIG
FT                   NGGAGGAGGQGLPFEAGANGGAGGAGGWLFGNGGAGGVGGAGGAGTTFGVAGGDGGTGG
FT                   VGGHGGLIGVGGHGGDGGTGGTGGAVSLARAGTAGGAGGGPAGGIGGAGGVGGAGGAAG
FT                   AVTTITHASFNDPHGVAVNPGGNIYVTNQGSNTVSVIDPVTNTVTGSITDGNGPSGVAV
FT                   SPVTGLVFVTNFDSNTVSVIDPNTNTVTGSIPVGTGAYGVAVNPGGNIYVTNQFSNTVS
FT                   VIDPATNTVTGSPIPVGLDPTGVAVNPVTGVVYVTNSLDDTVSVITGEPARSVCSAAI"
FT   CDS             63029..63721
FT                   /transl_table=11
FT                   /gene="mprA"
FT                   /locus_tag="Rv0981"
FT                   /product="MYCOBACTERIAL PERSISTENCE REGULATOR MRPA (TWO
FT                   COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN)"
FT                   /function="REGULATOR PART OF A TWO COMPONENT REGULATORY
FT                   SYSTEM (SUPPOSED MPRAB SYSTEM)."
FT                   /note="Rv0981, (MTV044.09), len: 230 aa. mprA,
FT                   mycobacterial persistence regulator, a two-component
FT                   response regulator whose expression is required for
FT                   entrance into and maintenance of persistent infection (see
FT                   citation below), equivalent to NP_301250.1|NC_002677
FT                   putative two-component response regulator from
FT                   Mycobacterium leprae (228 aa); and highly similar to others
FT                   from Mycobacterium leprae. Also highly similar to others
FT                   e.g. AAG36759.1|AF119221_1|AF119221 response regulator from
FT                   Corynebacterium glutamicum (232 aa); CAB88489.1|AL353816
FT                   putative two-component system response regulator from
FT                   Streptomyces coelicolor (248 aa); BJY09666_1 two-component
FT                   response regulator (ragA, ragB and rpoH3) from B.japonicum
FT                   (226 aa), FASTA score: (43.8% identity in 224 aa overlap);
FT                   BSAJ2571_44 two-component response regulator from Bacillus
FT                   subtilis (228 aa), FASTA score: (46.4% identity in 224 aa
FT                   overlap); etc. Also highly similar to others from
FT                   Mycobacterium tuberculosis e.g. Rv1033c (257 aa); Rv0903c
FT                   (236 aa), FASTA score: (50.7 identity in 225 aa overlap);
FT                   etc. Contains PS00217 Sugar transport proteins signature
FT                   2."
FT                   /db_xref="GOA:O53894"
FT                   /db_xref="HSSP:1KGS"
FT                   /db_xref="InterPro:IPR011991"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53894"
FT                   /protein_id="CAA17580.1"
FT                   /translation="MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASD
FT                   RPDALVLDVMMPRLDGLEVCRQLRGTGDDLPILVLTARDSVSERVAGLDAGADDYLPKP
FT                   FALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALL
FT                   EMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVG
FT                   YVLRETPP"
FT   misc_feature    63296..63373
FT                   /note="PS00217 Sugar transport proteins signature 2"
FT   CDS             63721..65235
FT                   /transl_table=11
FT                   /gene="mprB"
FT                   /locus_tag="Rv0982"
FT                   /product="PROBABLE TWO COMPONENT SENSOR KINASE MPRB"
FT                   /function="SENSOR PART OF A TWO COMPONENT REGULATORY SYSTEM
FT                   (SUPPOSED MPRAB SYSTEM)."
FT                   /EC_number="2.7.3.-"
FT                   /note="Rv0982, (MTV044.10), len: 504 aa. Probable mprB, two
FT                   component sensor kinase, transmembrane protein (EC 2.7.3.-)
FT                   (see citation below), equivalent to
FT                   AL035500|MLCL373_16|NP_301251.1|NC_002677 putative
FT                   two-component system sensor kinase from Mycobacterium
FT                   leprae (519 aa), FASTA score: (81.0% identity in 521 aa
FT                   overlap). Also highly similar to others (especially in
FT                   C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221 sensor
FT                   kinase from Corynebacterium glutamicum (455 aa);
FT                   CAB89748.1|AL354616 putative two-component histidine kinase
FT                   from Streptomyces coelicolor (481 aa); X58793|SLCUTRS_2
FT                   sensor kinase from S.lividans (414 aa), FASTA scores: opt:
FT                   451, E(): 4.2e-21, (36.0% identity in 303 aa overlap);
FT                   P30847|BAES_ECOLI SENSOR PROTEIN (EC 2.7.3.-) from
FT                   Escherichia coli (467 aa), FASTA scores: opt: 412, E():
FT                   1.3e-18, (30.4% identity in 336 aa overlap); etc. Also
FT                   similar in C-terminal region to C-terminus of
FT                   Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis
FT                   (446 aa), FASTA scores: opt: 423, E(): 2.6e-19, (28.4
FT                   identity in 462 aa overlap)."
FT                   /db_xref="GOA:O53895"
FT                   /db_xref="HSSP:1BXD"
FT                   /db_xref="InterPro:IPR005467"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53895"
FT                   /protein_id="CAA17581.1"
FT                   /translation="MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYA
FT                   VISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQ
FT                   PGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLR
FT                   WVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARL
FT                   TEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEM
FT                   VDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDILF
FT                   DVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPG
FT                   IPVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSI
FT                   YVLLPGRRMPIPQLPGATAGARSTDIENSRGSANVISVESQSTRAT"
FT   CDS             65279..66673
FT                   /transl_table=11
FT                   /gene="pepD"
FT                   /locus_tag="Rv0983"
FT                   /standard_name="mtb32b"
FT                   /product="PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE)
FT                   (MTB32B)"
FT                   /function="UNKNOWN; POSSIBLY HYDROLYZES PEPTIDES AND/OR
FT                   PROTEINS (SEEMS TO CLEAVE PREFERENTIALLY AFTER SERINE
FT                   RESIDUES)."
FT                   /EC_number="3.4.21.-"
FT                   /note="Rv0983, (MTV044.11), len: 464 aa. Probable pepD
FT                   (alternate gene name: mtb32b), secreted or membrane serine
FT                   protease (EC 3.4.21.-) (see citation below), equivalent
FT                   (but longer 18 aa in N-terminus) to
FT                   AL035500|MLCL373_17|T45448 probable serine proteinase (EC
FT                   3.4.21.-) from Mycobacterium leprae (452 aa), FASTA score:
FT                   (74.2% identity in 466 aa overlap); and highly similar to
FT                   others from Mycobacterium leprae. Also highly similar
FT                   (except in N-terminus) to other proteases e.g.
FT                   CAC01350.1|AL390975 putative protease from Streptomyces
FT                   coelicolor (542 aa); NP_440705.1|NC_000911|HtrA serine
FT                   protease from Synechocystis sp. (452 aa);
FT                   NP_346646.1|NC_003028 serine protease from Streptococcus
FT                   pneumoniae (393 aa); etc. Also similar in part to members
FT                   of the htrA-antigen family e.g. U87242|MTU87242_3|HtrA
FT                   serine protease from M. tuberculosis (542 aa), FASTA
FT                   scores: opt: 846, E(): 2e-28, (40.6% identity in 392 aa
FT                   overlap); and similar to other hypothetical serine
FT                   proteases e.g. Rv0983, Rv0125, etc. BELONGS TO THE SERINE
FT                   PROTEASE FAMILY."
FT                   /db_xref="GOA:O53896"
FT                   /db_xref="InterPro:IPR001254"
FT                   /db_xref="PDB:1Y8T"
FT                   /db_xref="UniProtKB/TrEMBL:O53896"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17582.1"
FT                   /translation="MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTY
FT                   SQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAI
FT                   GAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKV
FT                   VPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGR
FT                   TAPFTVVGADPTSDIAVVRVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTG
FT                   IVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGA
FT                   DSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVA
FT                   GGAAANAGVPKGVVVTKVDDRPINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVT
FT                   LGKAEQ"
FT   CDS             66673..67218
FT                   /transl_table=11
FT                   /gene="moaB2"
FT                   /locus_tag="Rv0984"
FT                   /product="POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE
FT                   MOAB2 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE)
FT                   (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE
FT                   HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN
FT                   CARBINOLAMINE DEHYDRATASE) (PCD)"
FT                   /function="THOUGHT TO BE INVOLVED IN MOLYBDOPTERIN
FT                   BIOSYNTHESIS. CATALYZES THE DEHYDRATATION OF
FT                   4A-HYDROXYTETRAHYDROPTERINS [CATALYTIC ACTIVITY:
FT                   (6R)-6-(L-ERYTHRO-1,2-DIHYDROXYPROPYL)-5,6,7,8-TETRAHYDRO
FT                   -4 A-HYDROXYPTERIN = (6R)-6-(L-ERYTHRO-1,2-
FT                   DIHYDROXYPROPYL)-7,8-DIHYDRO-6H-PTERIN + H(2)O.]."
FT                   /EC_number="4.2.1.96"
FT                   /note="Rv0984, (MTV044.12), len: 181 aa. Possible moaB2,
FT                   pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96),
FT                   highly similar to NP_301253.1|NC_002677 putative molybdenum
FT                   cofactor biosynthesis protein from Mycobacterium leprae
FT                   (181 aa), FASTA score: (92.3% identity in 181 aa overlap).
FT                   Also similar to others e.g. CAB59675.1|AL132674 molybdenum
FT                   cofactor biosynthesis protein from Streptomyces coelicolor
FT                   (179 aa); Q56208|MOCB_SYNP7 MOLYBDENUM COFACTOR
FT                   BIOSYNTHESIS PROTEIN CB from Synechococcus sp. (319 aa),
FT                   FASTA score: (37.3% identity in 142 aa overlap); C-terminus
FT                   of NP_197599.1|NC_003076 MOLYBDOPTERIN BIOSYNTHESIS CNX1
FT                   PROTEIN from Arabidopsis thaliana (670 aa); etc. Also
FT                   similar to Rv0865|MOG from Mycobacterium tuberculosis (160
FT                   aa); and other mog proteins e.g. CAC39235.1|AJ312124 Mog
FT                   protein from Eubacterium acidaminophilum (162 aa). COULD
FT                   BELONG TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE
FT                   FAMILY. Alternative start codon has been suggested in
FT                   position 1100508."
FT                   /db_xref="GOA:O53897"
FT                   /db_xref="HSSP:1O8Q"
FT                   /db_xref="InterPro:IPR001453"
FT                   /db_xref="UniProtKB/TrEMBL:O53897"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17583.1"
FT                   /translation="MKVAAQCSKLGYTVAPMEQRAELVVGRALVVVVDDRTAHGDEDHS
FT                   GPLVTELLTEAGFVVDGVVAVSADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRDVTPE
FT                   ATRDILDREILGIAEAIRASGLSAGIVDAGLSRGLAGVSGSTLVVNLAGSRYAVRDGMA
FT                   TLNPLAAQIIGQLSSLEI"
FT   CDS             complement(67238..67693)
FT                   /transl_table=11
FT                   /gene="mscL"
FT                   /locus_tag="Rv0985c"
FT                   /product="POSSIBLE LARGE-CONDUCTANCE ION MECHANOSENSITIVE
FT                   CHANNEL MSCL"
FT                   /function="ION CHANNEL THAT OPENS IN RESPONSE TO STRETCH
FT                   FORCES IN THE MEMBRANE LIPID BILAYER. MAY PARTICIPATE IN
FT                   THE REGULATION OF OSMOTIC PRESSURE CHANGES WITHIN THE
FT                   CELL."
FT                   /note="Rv0985c, (MTV044.13c), len: 151 aa. Possible mscL,
FT                   large conductance mechanosensitive ion channel (integral
FT                   membrane protein) (see citations below, equivalent to
FT                   AL035500|MLCL373_19|NP_301254.1|NC_002677 putative
FT                   mechanosensitive channel protein from Mycobacterium leprae
FT                   (154 aa), FASTA score: (71.0% identity in 155 aa overlap).
FT                   Also highly similar to others e.g. NP_268999.1|NC_002737
FT                   putative large conductance mechanosensitive channel from
FT                   Streptococcus pyogenes (120 aa); CAB90974.1|AL355832
FT                   putative mechanosensitive channel from Streptomyces
FT                   coelicolor (156 aa); Q9X722|MSCL_CLOHI LARGE-CONDUCTANCE
FT                   MECHANOSENSITIVE CHANNEL from Clostridium histolyticum (133
FT                   aa); Z83337|BSZ83337_6 large conductance mechanosensitive
FT                   channel from Bacillus subtilis (130 aa), FASTA scores: opt:
FT                   248, E(): 8.4e-10, (39.0% identity in 136 aa overlap);
FT                   U08371|ECU08371_1 large conductance mechanosensitive
FT                   channel from Escherichia coli strain K-12 (136 aa), FASTA
FT                   score: (36.6% identity in 134 aa overlap); etc. BELONGS TO
FT                   THE MSCL FAMILY."
FT                   /db_xref="GOA:P0A5K8"
FT                   /db_xref="InterPro:IPR001185"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5K8"
FT                   /protein_id="CAA17584.1"
FT                   /translation="MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINR
FT                   IGVNAQSDVGILRIGIGGGQTIDLNVLLSAAINFFLIAFAVYFLVVLPYNTLRKKGEVE
FT                   QPGDTQVVLLTEIRDLLAQTNGDSPGRHGGRGTPSPTDGPRASTESQ"
FT   CDS             68016..68762
FT                   /transl_table=11
FT                   /locus_tag="Rv0986"
FT                   /product="PROBABLE ADHESION COMPONENT TRANSPORT ATP-BINDING
FT                   PROTEIN ABC TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT                   ADHESION COMPONENT ACROSS THE MEMBRANE: INVOLVED IN
FT                   ATACHMENT AND VIRULENCE. RESPONSIBLE FOR ENERGY COUPLING TO
FT                   THE TRANSPORT SYSTEM."
FT                   /note="Rv0986, (MTV044.14), len: 248 aa. Probable
FT                   ATP-binding protein ABC transporter supposed involved in
FT                   transport of adhesion component (see citation below),
FT                   highly similar to many ATP-binding proteins e.g.
FT                   AE0010|AE001033_8 ABC transporter ATP-binding protein from
FT                   Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 669,
FT                   E(): 0, (45.7% identity in 219 aa overlap);
FT                   CAB81857.1|AL161691 putative ABC-transporter ATP-binding
FT                   protein from Streptomyces coelicolor (246 aa);
FT                   X84019|ZMDNAGRP_4 glutamate uptake regulatory protein (grp)
FT                   from Z.mobilis (232 aa), FASTA score: (44.4% identity in
FT                   225 aa overlap); Z99111|BSUB0008_108 from Bacillus subtilis
FT                   (230 aa), FASTA score: (38.7% identity in 222 aa overlap);
FT                   etc. Contains PS00017 ATP/GTP-binding site motif A
FT                   (P-loop), and PS00211 ABC transporters family signature.
FT                   BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC
FT                   TRANSPORTERS)."
FT                   /db_xref="GOA:O53899"
FT                   /db_xref="HSSP:1F3O"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53899"
FT                   /protein_id="CAA17585.1"
FT                   /translation="MNRQPIVQLSNLSWTFREGETRRQVLDHITFDFEPGEFVALLGQS
FT                   GSGKSTLLNLISGIEKPTTGDVTINGFAITQKTERDRTLFRRDQIGIVFQFFNLIPTLT
FT                   VLENITLPQELAGVSQRKAAVVARDLLEKVGMADRERTFPDKLSGGEQQRVAISRALAH
FT                   NPMLVLADEPTGNLDSDTGDKVLDVLLDLTRQAGKTLIMATHSPSMTQHADRVVNLQGG
FT                   RLIPAVNRENQTDQPASTILLPTSYE"
FT   misc_feature    68142..68165
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   misc_feature    68454..68498
FT                   /note="PS00211 ABC transporters family signature"
FT   CDS             68755..71322
FT                   /transl_table=11
FT                   /locus_tag="Rv0987"
FT                   /product="PROBABLE ADHESION COMPONENT TRANSPORT
FT                   TRANSMEMBRANE PROTEIN ABC TRANSPORTER"
FT                   /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT                   ADHESION COMPONENT ACROSS THE MEMBRANE: INVOLVED IN
FT                   ATACHMENT AND VIRULENCE. RESPONSIBLE FOR THE TRANSLOCATION
FT                   OF THE SUBSTRATE ACROSS THE MEMBRANE."
FT                   /note="Rv0987, (MTV044.15, MTCI237.01), len: 855 aa.
FT                   Probable transmembrane protein ABC transporter supposed
FT                   involved in transport of adhesion component (see citation
FT                   below), whose N-terminus shows similarity with hypothetical
FT                   proteins, generally transmembrane proteins, e.g.
FT                   CAB96016.1|AL360055 putative ABC transport system integral
FT                   membrane protein from Streptomyces coelicolor (855 aa);
FT                   P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from
FT                   Haemophilus influenzae (393 aa), FASTA scores: opt: 265,
FT                   E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N-
FT                   and C-termini respectively show similarity to O32735 ATTF
FT                   PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity
FT                   in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa),
FT                   FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa
FT                   overlap). Contains PS00017 ATP/GTP-binding site motif A
FT                   (P-loop)."
FT                   /db_xref="GOA:O53900"
FT                   /db_xref="InterPro:IPR003838"
FT                   /db_xref="UniProtKB/TrEMBL:O53900"
FT                   /protein_id="CAA17586.1"
FT                   /translation="MNDQAPVAYAPLWRTAWRRLRQRPFQYILLVLGIALGVAMIVAID
FT                   VSSNSAQRAFDLSAAAITGKSTHRLVSGPAGVDQQLYVDLRRHGYDFSAPVIEGYVLAR
FT                   GLGNRAMQFMGTDPFAESAFRSPLWSNQNIAELGGFLTRPNGVVLSRQVAQKYGLAVGD
FT                   RIALQVKGAPTTVTLVGLLTPADEVSNQKLSDLIIADISTAQELFHMPGRLSHIDLIIK
FT                   DEATATRIQQRLPAGVRMETSDTQRDTVKQMTDAFTVNLTALSLIALLVGIFLIYNTVT
FT                   FNVVQRRPFFAILRCLGVTREQLFWLIMTESLVAGLIGTGLGLLIGIWLGEGLIGLVTQ
FT                   TINDFYFVINVRNVSVSAESLLKGLIIGIFAAMLATLPPAIEAMRTVPASTLRRSSLES
FT                   KITKLMPWLWVAWFGLGSFGVLMLWLPGNNLVVAFVGLFSVLIALALIAPPLTRFVMLR
FT                   LAPGLGRLLGPIGRMAPRNIVRSLSRTSIAIAALMMAVSLMVGVSISVGSFRQTLANWL
FT                   EVTLKSDVYVSPPTLTSGRPSGNLPVDAVRNISKWPGVRDAVMARYSSVFAPDWGREVE
FT                   LMAVSGDISDGKRPYRWIDGNKDTLWPRFLAGKGVMLSEPMVSRQHLQMPPRPITLMTD
FT                   SGPQTFPVLAVFSDYTSDQGVILMDRASYRAHWQDDDVTTMFLFLASGANSGALIDQLQ
FT                   AAFAGREDIVIQSTHSVREASMFIFDRSFTITIALQLVATVVAFIGVLSALMSLELDRA
FT                   HELGVFRAIGMTTRQLWKLMFIETGLMGGMAGLMALPTGCILAWILVRIINVRSFGWTL
FT                   QMHFESAHFLRALLVAVVAALAAGMYPAWRLGRMTIRTAIREE"
FT   misc_feature    68929..68952
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             71329..72489
FT                   /transl_table=11
FT                   /locus_tag="Rv0988"
FT                   /product="POSSIBLE CONSERVED EXPORTED PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0988, (MTCI237.02), len: 386 aa. Possible
FT                   conserved exported protein, with potential N-terminal
FT                   signal sequence, similar (except in N-terminus) to
FT                   O32737|L63540 ATTH PROTEIN from Agrobacterium tumefaciens
FT                   (355 aa), FASTA scores: opt: 651, E(): 5.7e-33, (33.4%
FT                   identity in 344 aa overlap); and NP_231265.1|NC_002505
FT                   conserved hypothetical protein from Vibrio cholerae (372
FT                   aa)."
FT                   /db_xref="InterPro:IPR018549"
FT                   /db_xref="UniProtKB/TrEMBL:O86370"
FT                   /protein_id="CAA17587.1"
FT                   /translation="MRKAGLTGVVLVLTLTLVAFWWWQRPRTNAVAADSLVGVLVDENN
FT                   AGYSLATVPGAVRFPRDLGPHYDYQTEWWYYTGNLETADGRLFGYQLTFFRRALAPPGE
FT                   GVAIADASSWRTTQVYMAHFAISDISNRGFYPAEKFSRQALGLAGASSEPYAVWLDDWY
FT                   ARESNNNSVQLFARTQNTVLDLTLTQTLPPILQGNAGLSVKGAQPGNASNYYSLVRQES
FT                   RGTVSVNGDTFMVSGLSWKDHEYMTSALAPEDVGWDWFGLQFYNGTALMLFQIRQADGS
FT                   VTRFSSGTFVAGDGGVIPLESSDFRIKTTDRWTSDQSGATYPIAWEIEIERIGLTLRGA
FT                   ALMANQELRLSRTYWEGAVALEGRYQGMPISGRGYVEMTGYVQRLS"
FT   CDS             complement(72618..73595)
FT                   /transl_table=11
FT                   /gene="grcC2"
FT                   /locus_tag="Rv0989c"
FT                   /product="PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC2
FT                   (POLYPRENYL PYROPHOSPHATE SYNTHETASE)"
FT                   /function="POSSIBLE SUPPLIER OF POLYPRENYL DIPHOSPHATE."
FT                   /EC_number="2.5.1.-"
FT                   /note="Rv0989c, (MTCI237.03c), len: 325 aa. Probable grcC2,
FT                   polyprenyl diphosphate synthetase (EC 2.5.1.-), highly
FT                   similar to NP_302483.1|NC_002677 polyprenyl diphosphate
FT                   synthase component from Mycobacterium leprae (330 aa). Also
FT                   similar to others (generally hepta (EC 2.5.1.30) or
FT                   hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to
FT                   heptaprenyl diphosphate synthase component II (menaquinone
FT                   biosynthesis) from Listeria innocua (321 aa);
FT                   NP_371994.1|NC_002758 heptaprenyl diphosphate syntase
FT                   component II from Staphylococcus aureus subsp. aureus Mu50
FT                   (319 aa); P55785|HEP2_BACST heptaprenyl diphosphate
FT                   synthase component from Bacillus subtilis (323 aa), FASTA
FT                   scores: opt: 496, E(): 1.4e-24, (31.4% identity in 306 aa
FT                   overlap); etc. Also highly similar to Mycobacterium
FT                   tuberculosis proteins e.g.
FT                   Rv0562|grcC1|NP_215076.1|MTCY25D10.41 PROBABLE
FT                   POLYPRENYL-DIPHOSPHATE SYNTHASE (335 aa); Rv3383, Rv3398c,
FT                   Rv2173, etc. SEEMS TO BELONG TO THE FPP/GGPP SYNTHETASES
FT                   FAMILY."
FT                   /db_xref="GOA:O05572"
FT                   /db_xref="InterPro:IPR000092"
FT                   /db_xref="UniProtKB/TrEMBL:O05572"
FT                   /protein_id="CAB08149.1"
FT                   /translation="MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHL
FT                   VDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMSRKTP
FT                   SDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPASHI
FT                   DTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAI
FT                   SGDSATLSGADLGQAVHTLPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSP
FT                   GIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHAISACD"
FT   CDS             complement(73656..74312)
FT                   /transl_table=11
FT                   /locus_tag="Rv0990c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0990c, (MTCI237.04c), len: 218 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="InterPro:IPR013974"
FT                   /db_xref="UniProtKB/TrEMBL:O05573"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08150.1"
FT                   /translation="MAESSLNPSLVSRISAFLRPDWTRTVRARRFAAAGLVMLAGVAAL
FT                   RSNPEDDRSEVVVAAHDLRPGTALTPGDVRLEKRSATTLPDGSQADLDAVVGSTLASPT
FT                   RRGEVLTDVRLLGSRLAESTAGPDARIVPLHLADSALVDLVRVGDVVDVLAAPVTDSPA
FT                   ALRLLATDAIVVLVSAQQKAQAADSDRVVLVALPARLANTVAGAALGQTVTLTLH"
FT   CDS             complement(74385..74717)
FT                   /transl_table=11
FT                   /locus_tag="Rv0991c"
FT                   /product="CONSERVED HYPOTHETICAL SERINE RICH PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0991c, (MTCI237.05c), len: 110 aa. Conserved
FT                   hypothetical ser-rich protein (especially in C-terminus),
FT                   highly similar to N-terminus of NP_301255.1|NC_002677
FT                   conserved hypothetical protein (Ser-rich C-terminus) from
FT                   Mycobacterium leprae (99 aa). Also highly similar to
FT                   SCE22.04|AB90971.1|AL355832 hypothetical protein from
FT                   Streptomyces coelicolor (110 aa); and similar to others."
FT                   /db_xref="InterPro:IPR013429"
FT                   /db_xref="UniProtKB/TrEMBL:O05574"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08151.1"
FT                   /translation="MPTYSYECTQCANRFDVVQAFTDDALTTCERCSGRLRKLFNAVGV
FT                   VFKGTGFYRTDSRESGKKSKSQTNGSSTSESTKSSGSSGSSGSSESKASGSTEKSTSST
FT                   TAAAAV"
FT   CDS             complement(74791..75384)
FT                   /transl_table=11
FT                   /locus_tag="Rv0992c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0992c, (MTCI237.06c), len: 197 aa. Conserved
FT                   hypothetical protein, equivalent to NP_301256.1|NC_002677
FT                   conserved hypothetical protein from Mycobacterium leprae
FT                   (197 aa). Also similar, except in N-terminus, to other
FT                   hypothetical proteins and ligases e.g.
FT                   SCE87.34|CAB59679.1|AL132674 hypothetical protein from
FT                   Streptomyces coelicolor (204 aa); NP_461977.1|NC_003197
FT                   putative ligase from Salmonella typhimurium (182 aa);
FT                   P09160|YGFA_ECOLI HYPOTHETICAL 21.1 kDa PROTEIN from
FT                   Escherichia coli (182 aa), FASTA scores: opt: 191, E():
FT                   1.1e-09, (29.5% identity in 146 aa overlap); etc."
FT                   /db_xref="GOA:O05575"
FT                   /db_xref="InterPro:IPR002698"
FT                   /db_xref="UniProtKB/TrEMBL:O05575"
FT                   /protein_id="CAB08152.1"
FT                   /translation="MAMASKSALRDQLLAARRRVADDVRAAEARMLRGHLERMVTSDST
FT                   VCAYVPVGGEPGSIEMLDVLLRRAGRVLLPVARTAGGDLPLPLRWGEYRAGGLARARWG
FT                   LLEPPEPWLPEAALAQASLVLVPALAVDRQGVRLGRGRGFYDRSLRCRDPHARLVAVVR
FT                   TVELVDVLPSEPHDVPMTHALTPERGLIALPCGE"
FT   CDS             75485..76405
FT                   /transl_table=11
FT                   /gene="galU"
FT                   /locus_tag="Rv0993"
FT                   /product="PROBABLE UTP--GLUCOSE-1-PHOSPHATE
FT                   URIDYLYLTRANSFERASE GALU (UDP-GLUCOSE PYROPHOSPHORYLASE)
FT                   (UDPGP) (ALPHA-D-GLUCOSYL-1-PHOSPHATE URIDYLYLTRANSFERASE)
FT                   (URIDINE DIPHOSPHOGLUCOSE PYROPHOSPHORYLASE)"
FT                   /function="MAY PLAY A ROLE IN STATIONARY PHASE SURVIVAL
FT                   [CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate =
FT                   diphosphate + UDP-glucose]."
FT                   /EC_number="2.7.7.9"
FT                   /note="Rv0993, (MTCI237.07), len: 306 aa. Probable galU,
FT                   UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9),
FT                   equivalent to AL035500|MLCL373_22 putative
FT                   UTP-glucose-1-phosphate uridylyltransferase from
FT                   Mycobacterium leprae (306 aa), FASTA score: (89.7% identity
FT                   in 302 aa overlap). Also highly similar to others e.g.
FT                   AB59678.1|AL132674 UTP-glucose-1-phosphate
FT                   uridylyltransferase from Streptomyces coelicolor (303 aa);
FT                   NP_244519.1|NC_002570 UTP-glucose-1-phosphate
FT                   uridylyltransferase from Bacillus halodurans (297 aa);
FT                   P25520|GALU_ECOLI|B1236|Z2012|ECS17
FT                   UTP--glucose-1-phosphate uridylyltransferase from
FT                   Escherichia coli strains K12 and O157:H7 (301 aa), FASTA
FT                   scores: opt: 624, E(): 2.4e-33, (38.8% identity in 299 aa
FT                   overlap); etc. BELONGS TO THE PROKARYOTIC UDPGP FAMILY."
FT                   /db_xref="GOA:O05576"
FT                   /db_xref="InterPro:IPR005835"
FT                   /db_xref="UniProtKB/TrEMBL:O05576"
FT                   /protein_id="CAB08153.1"
FT                   /translation="MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIEL
FT                   VAAEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKIAMLAKVRRAPALIKV
FT                   ESVVQAEPLGLGHAIGCVEPTLSPDEDAVAVLLPDDLVLPTGVLETMSKVRASRGGTVL
FT                   CAIEVAREEISAYGVFDVEPVPDGDYTDDPNVLKVRGMVEKPKAETAPSRYAAAGRYVL
FT                   DRAIFDALRRIDQGAGGEVQLTDAIALLIAEGHPVHVVVHQGSRHDLGNPGGYLKAAVD
FT                   FALDRDDYGPDLRRWLVARLGLTEQ"
FT   CDS             76482..77762
FT                   /transl_table=11
FT                   /gene="moeA1"
FT                   /locus_tag="Rv0994"
FT                   /standard_name="moeA"
FT                   /product="PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN
FT                   MOEA1"
FT                   /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS:
FT                   INVOLVED IN THE BIOSYNTHESIS OF A DEMOLYBDO-COFACTOR
FT                   (MOLYBDOPTERIN), NECESSARY FOR MOLYBDO-ENZYMES."
FT                   /note="Rv0994, (MTCI237.08), len: 426 aa. Probable moeA1,
FT                   molybdenum cofactor biosynthesis protein, equivalent to
FT                   AL035500|MLCL373_23 putative molybdopterin biosynthesis
FT                   protein from Mycobacterium leprae (424 aa), FASTA score:
FT                   (88.3% identity in 426 aa overlap). Also highly similar to
FT                   many e.g. CAB59677.1|AL132674 molybdopterin biosynthesis
FT                   protein from Streptomyces coelicolor (424 aa);
FT                   NP_385769.1|NC_003047 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS
FT                   PROTEIN from Sinorhizobium meliloti (406 aa);
FT                   P12281|MOEA_ECOLI molybdopterin biosynthesis moea protein
FT                   from Escherichia coli (411 aa), FASTA scores: opt: 519,
FT                   E(): 1.3e-24, (32.3% identity in 402 aa overlap); etc. Also
FT                   similar to MOEA2|Rv0438c|MTV037.02c PROBABLE MOLYBDOPTERIN
FT                   BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (405
FT                   aa). Note that previously known as moeA."
FT                   /db_xref="GOA:O05577"
FT                   /db_xref="HSSP:1G8L"
FT                   /db_xref="InterPro:IPR001453"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05577"
FT                   /protein_id="CAE55346.1"
FT                   /translation="MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPG
FT                   FDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQ
FT                   PRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAV
FT                   RAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYAL
FT                   AAAGRDACAEVNRVGIVSNDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSEL
FT                   GEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHP
FT                   MRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEAN
FT                   CLVVVPTGAEQIRTGEIVDVAFLAQHG"
FT   CDS             77825..78436
FT                   /transl_table=11
FT                   /gene="rimJ"
FT                   /locus_tag="Rv0995"
FT                   /product="POSSIBLE RIBOSOMAL-PROTEIN-ALANINE
FT                   ACETYLTRANSFERASE RIMJ (ACETYLATING ENZYME FOR N-TERMINAL
FT                   OF RIBOSOMAL PROTEIN S5)"
FT                   /function="THIS ENZYME ACETYLATES THE N-TERMINAL ALANINE OF
FT                   RIBOSOMAL PROTEIN S5 [CATALYTIC ACTIVITY: ACETYL-CoA +
FT                   RIBOSOMAL-PROTEIN L-ALANINE = CoA + RIBOSOMAL-PROTEIN
FT                   N-ACETYL-L-ALANINE]."
FT                   /EC_number="2.3.1.128"
FT                   /note="Rv0995, (MTCI237.09), len: 203 aa. Possible rimJ,
FT                   ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128),
FT                   equivalent to AL035500|MLCL373_24 probable acyltransferase
FT                   from Mycobacterium leprae (218 aa), FASTA scores: (86.0%
FT                   identity in 200 aa overlap). Also similar to others and
FT                   many acyltransferases e.g. BAB69252.1|AB070946 possible
FT                   acyltransferase from Streptomyces avermitilis (156 aa);
FT                   NP_385025.1|NC_003047 PROBABLE RIBOSOMAL-PROTEIN-ALANINE
FT                   ACETYLTRANSFERASE from Sinorhizobium meliloti (203 aa);
FT                   P09454|RIMJ_ECOLI|B1066|Z1703|ECS1444
FT                   ribosomal-protein-alanine acetyltransferase from
FT                   Escherichia coli strains K12 and O157:H7 (194 aa), FASTA
FT                   scores: opt: 247, E(): 1.5e-10, (26.9% identity in 186 aa
FT                   overlap). SEEMS TO BELONG TO THE ACETYLTRANSFERASE FAMILY,
FT                   RIMJ SUBFAMILY."
FT                   /db_xref="GOA:O05578"
FT                   /db_xref="InterPro:IPR016181"
FT                   /db_xref="UniProtKB/TrEMBL:O05578"
FT                   /protein_id="CAB08155.1"
FT                   /translation="MAVGPLRVSAGVIRLRPVRMRDGVHWSRIRLADRAHLEPWEPSAD
FT                   GEWTVRHTVAAWPAVCSGLRSEARNGRMLPYVIELDGQFCGQLTIGNVTHGALRSAWIG
FT                   YWVPSAATGGGVATGALALGLDHCFGPVMLHRVEATVRPENAASRAVLAKVGFREEGLL
FT                   RRYLEVDRAWRDHLLMAITVEEVYGSVASTLVRAGHASWP"
FT   CDS             78597..79673
FT                   /transl_table=11
FT                   /locus_tag="Rv0996"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0996, (MTCI237.10), len: 358 aa. Probable
FT                   conserved transmembrane protein, equivalent to
FT                   AL035500|MLCL373_25 putative membrane protein from
FT                   Mycobacterium leprae (342 aa), FASTA scores: (66.4%
FT                   identity in 360 aa overlap). Contains possible signal
FT                   sequence and other hydrophobic domains."
FT                   /db_xref="GOA:O05579"
FT                   /db_xref="UniProtKB/TrEMBL:O05579"
FT                   /protein_id="CAB08146.1"
FT                   /translation="MPSIPQSLLWISLVVLWLFVLVPMLISKRDAVRRTSDVALATRVL
FT                   NGGAGARLLKRGGPAAGHRWGYLPPEGQGDDPDWKPEEDWRDDPVEDGFADVEHDIDED
FT                   QEADDARRRGAVVMKVAAPQTAGADEPDYLDVDVVEEDSEALPVGAGAAVGESADEADA
FT                   EAADGVAGHADPEADPVEYEYEYEYVEDTCGLELEEDDQEAPPTVASGTSRRRRFDTKT
FT                   AAAVSARKYTFRKRALIVMAVILVGSAAAAFELTPVAWWICGSATGVTVLYLAYLRRQT
FT                   RIEEKVRRRRMQRIARARLGVENTRDREYDVVPSRLRRPGAVVLEIDDEDPIFTHLESA
FT                   APIRNYGWPRDLPRAVGQ"
FT   tRNA            79724..79796
FT                   /gene="tRNA-Ala(CGC)"
FT                   /product="transfer RNA-Ala(CGC)"
FT                   /anticodon=(pos:79757..79759,aa:Ala)
FT   CDS             80506..80937
FT                   /transl_table=11
FT                   /locus_tag="Rv0997"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0997, (MTCI237.11), len: 143 aa. Hypothetical
FT                   unknown protein, equivalent to AAK45276.1 from
FT                   Mycobacterium tuberculosis strain CDC1551 (87 aa) but
FT                   longer 56 aa."
FT                   /db_xref="UniProtKB/TrEMBL:O05580"
FT                   /protein_id="CAB08147.1"
FT                   /translation="MAGIAGVDRDPPGWPQHSHLLAGDPERFRHQLQRAETTNSIECFV
FT                   AEWHHAGVAADMTRPWPTVVQGGAGQRRRRDVEPDRKTPVRWMSGQRLSEITWPTTDIE
FT                   HSVGAAEVQRHRGAVPLGSGGDAAGKVEGGRTPQPFVQP"
FT   CDS             80961..81962
FT                   /transl_table=11
FT                   /locus_tag="Rv0998"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0998, (MTCI237.12), len: 333 aa. Conserved
FT                   hypothetical protein, possibly cyclic nucleotide-dependent
FT                   protein kinase (EC 2.7.-.-), highly similar to
FT                   NP_301261.1|NC_002677 conserved hypothetical protein from
FT                   Mycobacterium leprae (353 aa); and
FT                   AL035500|MLCL373.38|T45457 hypothetical protein from
FT                   Mycobacterium leprae (143 aa), FASTA score: (61.5% identity
FT                   in 143 aa overlap). Also similar to many hypothetical
FT                   proteins and cyclic-NMP-dependent protein kinases
FT                   (generally at C-terminus) e.g. N-terminus of
FT                   SC9B10.09|T35878 hypothetical protein from Streptomyces
FT                   coelicolor (1039 aa); P05987|KAPR_DICDI CAMP-DEPENDENT
FT                   PROTEIN KINASE REGULATORY CHAIN (EC 2.7.1.37) from
FT                   Dictyostelium discoideum (327 aa), FASTA scores: opt: 177,
FT                   E(): 0.00036, (32.0% identity in 122 aa overlap);
FT                   NP_104403.1|NC_002678 hypothetical protein (contains
FT                   similarity to cAMP-dependent protein kinase regulatory
FT                   subunit) from Mesorhizobium loti (151 aa); etc. Contains
FT                   PS00889 Cyclic nucleotide-binding domain signature 2."
FT                   /db_xref="GOA:O05581"
FT                   /db_xref="InterPro:IPR018488"
FT                   /db_xref="UniProtKB/TrEMBL:O05581"
FT                   /protein_id="CAB08156.1"
FT                   /translation="MDGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQ
FT                   VLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTT
FT                   IEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLP
FT                   GDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADA
FT                   RFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMR
FT                   TIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG"
FT   misc_feature    81219..81272
FT                   /note="PS00889 Cyclic nucleotide-binding domain signature
FT                   2"
FT   CDS             81980..82738
FT                   /transl_table=11
FT                   /locus_tag="Rv0999"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv0999, (MTCI237.13), len: 252 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O05582"
FT                   /protein_id="CAB08148.1"
FT                   /translation="MRPPLAPQFAADLLVKTVSTLRSSGAALGRLTTMRKAVLAVGSVC
FT                   WLVGCSSGASSTTASTGDIAKVAEVKSGFGPEYTVTDVTPRAIDPGFFSARKLPDGLSF
FT                   DPANCAQVAAGPQLPTGLQGNMAAVSAEGNGNRFVVIAVETSQPLPAPSPGKDCSKVTF
FT                   SGTQLRGGIEVVDVPHIDGTQTLGVHRVLQAVVGGSARTGELYDYSARFGDYQVIVIAN
FT                   PLVIPGRPVARVDTQRARDLLVQAVAAVRG"
FT   CDS             complement(82744..83361)
FT                   /transl_table=11
FT                   /locus_tag="Rv1000c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN. THOUGHT TO BE
FT                   REGULATED BY Rv2720|LEXA."
FT                   /function="UNKNOWN"
FT                   /note="Rv1000c, len: 205 aa. Conserved hypothetical
FT                   protein, equivalent to ML0190|NP_301263.1|NC_002677
FT                   conserved hypothetical protein from Mycobacterium leprae
FT                   (205 aa). Also highly similar to
FT                   SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from
FT                   Streptomyces coelicolor (210 aa), FASTA scores: E():
FT                   2.1e-45, (56.8% identity);
FT                   9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein
FT                   described as DNA repair system specific for alkylated DNA
FT                   from Xylella fastidiosa (200 aa), FASTA scores: E():
FT                   3.4e-14, (38.55% identity); and similar in C-terminus to
FT                   other hypothetical proteins. Note that replaces original
FT                   Rv1000 predicted on other strand."
FT                   /db_xref="UniProtKB/TrEMBL:Q8VK98"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55347.1"
FT                   /translation="MCDKLGGVAIAVQGALFEHNERRQLGDGAFIDIRSGWLTGGEELL
FT                   DALLSTVPWRAERRQMYDRVVDVPRLVSFHDLTIEDPPHPQLARMRRRLNDIYGGELGE
FT                   PFTTAGLCYYRDGSDSVAWHGDTIGRGSTEDTMVAIVSLGATRVFALRPRGRGPSLRLP
FT                   LAHGDLLVMGGSCQRTFEHAVPKTSAPTGPRVSIQFRPRDVR"
FT   CDS             83398..84606
FT                   /transl_table=11
FT                   /gene="arcA"
FT                   /locus_tag="Rv1001"
FT                   /product="PROBABLE ARGININE DEIMINASE ARCA (ADI) (AD)
FT                   (ARGININE DIHYDROLASE)"
FT                   /function="ARGININE DEGRADATION [CATALYTIC
FT                   ACTIVITY:L-ARGININE + H(2)O = L-CITRULLINE + NH(3)]"
FT                   /EC_number="3.5.3.6"
FT                   /note="Rv1001, (MTCI237.16), len: 402 aa. Probable arcA,
FT                   arginine deiminase (EC 3.5.3.6), similar to e.g.
FT                   ARCA_PSEAE|P13981 arginine deiminase (417 aa), fasta
FT                   scores: opt: 581, E(): 1.4e-31, (39.4% identity in 411 aa
FT                   overlap); also similar to SAGP_STRPY|P16962 streptococcal
FT                   acid glycoprotein (410 aa), FASTA scores, opt: 823, E():0,
FT                   (38.3% identity in 402 aa overlap). BELONGS TO THE ARGININE
FT                   DEIMINASE FAMILY."
FT                   /db_xref="GOA:P63551"
FT                   /db_xref="InterPro:IPR003876"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63551"
FT                   /protein_id="CAB08144.1"
FT                   /translation="MGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPWV
FT                   SRAQDEHDEFAELLASRGAEVLLLSDLLTEALHHSGAARMQGIAAAVDAPRLGLPLAQE
FT                   LSAYLRSLDPGRLAHVLTAGMTFNELPSDTRTDVSLVLRMHHGGDFVIEPLPNLVFTRD
FT                   SSIWIGPRVVIPSLALRARVREASLTDLIYAHHPRFTGVRRAYESRTAPVEGGDVLLLA
FT                   PGVVAVGVGERTTPAGAEALARSLFDDDLAHTVLAVPIAQQRAQMHLDTVCTMVDTDTM
FT                   VMYANVVDTLEAFTIQRTPDGVTIGDAAPFAEAAAKAMGIDKLRVIHTGMDPVVAEREQ
FT                   WDDGNNTLALAPGVVVAYERNVQTNARLQDAGIEVLTIAGSELGTGRGGPRCMSCPAAR
FT                   DPL"
FT   CDS             complement(84641..86152)
FT                   /transl_table=11
FT                   /locus_tag="Rv1002c"
FT                   /product="CONSERVED MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1002c, (MTCI237.17c), len: 503 aa. Conserved
FT                   membrane protein. Similar to AL132674|SCE87.05 hypothetical
FT                   protein from Streptomyces coelicolor (591 aa), FASTA
FT                   scores: opt: 666, E(): 0, (39.0% identity in 546 aa
FT                   overlap); weakly similar and to TSCC_PSEAM|P55019
FT                   thiazide-sensitive sodium-chloride cotransporter from
FT                   Pseudopleuronectes americanus (1023 aa), FASTA scores: opt:
FT                   44, E(): 4.2e-06, (22.4% identity in 326 aa overlap)."
FT                   /db_xref="GOA:O05586"
FT                   /db_xref="InterPro:IPR003342"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05586"
FT                   /protein_id="CAB08157.1"
FT                   /translation="MVPVVSPGPLVPVADFGPLDRLRGWIVTGLITLLATVTRFLNLGS
FT                   LTDAGTPIFDEKHYAPQAWQVLNNHGVEDNPGYGLVVHPPVGKQLIAIGEAIFGYNGFG
FT                   WRFTGALLGVVLVALVVRIVRRISRSTLVGAIAGVLLICDGVSFVTARTALLDGFLTFF
FT                   VVAAFGALIVDRDQVRERMHIALLAGRSAATVWGPRVGVRWWRFGAGVLLGLACATKWS
FT                   GVYFVLFFGAMALAFDVAARRQYQVQRPWLGTVRRDVLPSGYALGLIPFAVYLATYAPW
FT                   FASETAIDRHAVGQAVGRNSVVPLPDAVRSLWHYTAKAFHFHAGLTNSAGNYHPWESKP
FT                   WTWPMSLRPVLYAIDQQDVAGCGAQSCVKAEMLVGTPAMWWLAVPVLAYAGWRMFVRRD
FT                   WRYAVVLVGYCAGWLPWFADIDRQMYFFYAATMAPFLVMGISLVLGDILYHPGQGSERR
FT                   TLGLIVVCCYVALVVTNFAWLYPVLTGLPISQQTWNLEIWLPSWR"
FT   misc_feature    complement(85502..85534)
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             86235..87092
FT                   /transl_table=11
FT                   /locus_tag="Rv1003"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1003, (MTCI237.19), len: 285 aa. Conserved
FT                   hypothetical protein, similar to others e.g.
FT                   AL132674|SCE87.04 Streptomyces coelicolor (286 aa), FASTA
FT                   scores: opt: 877, E(): 0, (53.2% identity in 280 aa
FT                   overlap); and YRAL_ECOLI|P45528 hypothetical 31.3 kd
FT                   protein (286 aa), FASTA scores: opt: 561, E(): 4.4e-27,
FT                   (36.9% identity in 279 aa overlap)."
FT                   /db_xref="GOA:P0A640"
FT                   /db_xref="InterPro:IPR018063"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A640"
FT                   /protein_id="CAB08145.1"
FT                   /translation="MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLA
FT                   KALDIRIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLVAACI
FT                   DAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWLAELAEERRTCVFF
FT                   ESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVVRGSLDELAIWAAGGVLGEITVV
FT                   VAGAAPHAELSSLIAQVEEFVAAGIRVKDACSEVAAAHPGVRTRQLYDAVLQSRRETGG
FT                   PAQP"
FT   CDS             complement(87102..88361)
FT                   /transl_table=11
FT                   /locus_tag="Rv1004c"
FT                   /product="PROBABLE MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1004c, (MTCI237.20c), len: 419 aa. Probable
FT                   membrane protein. Contains repetitive sequences, which have
FT                   similarities with elastin, and possible N-terminal signal
FT                   sequence."
FT                   /db_xref="UniProtKB/TrEMBL:O05589"
FT                   /protein_id="CAB08158.1"
FT                   /translation="MSISCRVREGFVMRLAIVGTAAAAAIGGTLAVAPLTLSTPERVAG
FT                   GTCSAGQQCDRLAAVLMPDTATPSGPAAAEHAVPAPFEPVADTIAPGLVPRPGVPAAAA
FT                   VPRVGPPAVPGLPNIPGAAGPALPPPPALPNLAAPSVPGVGIPGIGIPGIGIPGIGIPG
FT                   VPDPITGVNTAAAVVNGVLGVGGTAAGVVTASAVAVTYLVLAVNALESSGILPTARGTA
FT                   STVASLLLPGAQSAAAALPAVGLPALPGVTPASLLAMAAAAGLPGVGFPSLPGVSPTDL
FT                   MAMAAAAGLPTSLPGLAGMSPAELTALVAGGLPMLAAAGLPAGLAGVDPATLAAALPAL
FT                   AAGGLPPGLPALPGVDPAALAAALPALAAGLPALPAGLPPLPAVPALPAPPPLPGPPPL
FT                   PALPSRLCTPGFGPIGVCIP"
FT   CDS             complement(88435..89811)
FT                   /transl_table=11
FT                   /gene="pabB"
FT                   /locus_tag="Rv1005c"
FT                   /product="Probable para-aminobenzoate synthase component I
FT                   PABD"
FT                   /function="CATALYZES THE BIOSYNTHESIS OF
FT                   4-AMINO-4-DEOXYCHORISMATE (ADC) FROM CHORISMATE AND
FT                   GLUTAMINE"
FT                   /EC_number="4.1.3.-"
FT                   /note="Rv1005c, (MTCI237.22c), len: 458 aa (Start-site not
FT                   certain). Probable PabD, para-aminobenzoate synthase
FT                   component I (EC 4.1.3.-). Similar to PABB_ECOLI|P05041
FT                   para-aminobenzoate synthase component I from Escherichia
FT                   coli (453 aa), FASTA scores: opt: 589, E(): 1.8e-27, (40.7%
FT                   identity in 268 aa overlap). Similar to M. tuberculosis
FT                   Rv1609, Rv3215, Rv2386c."
FT                   /db_xref="GOA:O05591"
FT                   /db_xref="HSSP:1K0G"
FT                   /db_xref="InterPro:IPR015890"
FT                   /db_xref="UniProtKB/TrEMBL:O05591"
FT                   /protein_id="CAB08140.1"
FT                   /translation="MNLAWELSTRTKSPRSHLRCENPQFCQARTVRIDRLGDLGGAPAV
FT                   LRAVGRATSRLDLPPPAALTGEWFGALAVIAPSVSIQPVSGDDVFSGPPGTGGPDATGA
FT                   VGGGWVGYLSYPDAGADGRPHRIPEAAGGWTDCVLRRDRDGQWWYESLSGAPIADWLAS
FT                   ALATTRASVARPAPACRIDWEPADRAAHRDGVLACLEAIGAGEVYQACVCTQFAGTVTG
FT                   SPLDFFIDGFGRTAPSRSAFVAGPWGAVASLSPELFLRRRGSVVTSSPIKGTLPLDAPP
FT                   SALRASAKEVAENIMIVDLVRNDLGRVAVTGTVTVPELLVVRPAPGVWHLVSTVSARVP
FT                   LEEPMSALLDAAFPPASVTGTPKLRARQLISQWERYRRGIYCGTVGLASPVAGCELNVA
FT                   IRTVEFDTAGNAVLGVGGGITADSDPDAEWAECLHKAAPIVGLPAATRTTPARLASKVR
FT                   "
FT   CDS             89927..91630
FT                   /transl_table=11
FT                   /locus_tag="Rv1006"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1006, (MTCI237.23), len: 567 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O05592"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08141.1"
FT                   /translation="MVLRSRKSTLGVVVCLALVLGGPLNGCSSSASHRGPLNAMGSPAI
FT                   PSTAQEIPNPLRGQYEDLMEPLFPQGNPAQQRYPPWPASYDASLRVSWRQLQPTDPRTL
FT                   PPDAPDDRKYDFSVIDNALTRLADRGMRLTLRVYAYSSCCKASYPDGTNIAIPDWERAI
FT                   ASTNTSYPGPATDPSTGVVQVVPNFNDSTYLNDFAQLLAALGRRYDGDERLSVFEFSGY
FT                   GDFSENHVAYLRDTLGAPGPGPDESVATLGYYSQFRDQNITTASIKQLIAANVSAFPHT
FT                   QLVTSPANPEIVRELFADEVTNKLAAPVGVRSDCLGVDAPLPAWAESSTSHYVQTKDPV
FT                   VAALRQRLATAPVITEWCELPTGSSPRAYYEKGLRDVIRYHVSMTSSVNFPDQTATSPM
FT                   DPALYLVWAQANAAAGYRYSVEAQPGSQALAGKVATISVTWTNYGAAAATEKWVPGYRL
FT                   VDSTGQVVRTLPAAVDLKTLVSDQRGDRSSDQPTPASVAETVRVDLSGLPAGHYTLRAA
FT                   IDWQQHKPNGSHVVNYPPMLLSRDGRDDSGFYPVATLDIPRDAQTAVNAS"
FT   CDS             complement(91657..93216)
FT                   /transl_table=11
FT                   /gene="metS"
FT                   /locus_tag="Rv1007c"
FT                   /product="PROBABLE METHIONYL-TRNA SYNTHETASE METS (MetRS)
FT                   (Methionine--tRNA ligase)"
FT                   /function="IT IS PROBABLY ESSENTIAL FOR CELL SURVIVAL,
FT                   BEING REQUIRED NOT ONLY FOR ELONGATION OF PROTEIN SYNTHESIS
FT                   BUT ALSO FOR THE INITIATION OF ALL MRNA TRANSLATION THROUGH
FT                   INITIATOR TRNA(FMET) AMINOACYLATION [CATALYTIC ACTIVITY:
FT                   ATP + L-METHIONINE + TRNA(MET) = AMP + DIPHOSPHATE +
FT                   L-METHIONYL-TRNA(MET)]"
FT                   /EC_number="6.1.1.10"
FT                   /note="Rv1007c, (MTCI237.24), len: 519 aa. Probable metS
FT                   (MetG), methionyl-tRNA synthetase (EC 6.1.1.10), similar to
FT                   many e.g. SYM_BACSU|P37465 methionyl-tRNA synthetase from
FT                   Bacillus subtilus (664 aa), FASTA scores: opt: 1506, E():
FT                   0, (44.9% identity in 492 aa overlap); similar to other
FT                   Mycobacterium tuberculosis tRNA synthases e.g. Rv2448c,
FT                   Rv1536, Rv0041. Contains PS00178 Aminoacyl-transfer RNA
FT                   synthetases class-I signature. BELONGS TO CLASS-I
FT                   AMINOACYL-TRNA SYNTHETASE FAMILY. STRONG, TO CYSTEINYL-TRNA
FT                   SYNTHETASE."
FT                   /db_xref="GOA:O05593"
FT                   /db_xref="HSSP:1A8H"
FT                   /db_xref="InterPro:IPR014758"
FT                   /db_xref="UniProtKB/Swiss-Prot:O05593"
FT                   /protein_id="CAB08142.1"
FT                   /translation="MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDRYDVRFL
FT                   TGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASK
FT                   ELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYF
FT                   FRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPD
FT                   HVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGI
FT                   ELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSD
FT                   EAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVR
FT                   GHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRI
FT                   AALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPE
FT                   GK"
FT   misc_feature    complement(93151..93180)
FT                   /note="PS00178 Aminoacyl-transfer RNA synthetases class-I
FT                   signature"
FT   CDS             93302..94096
FT                   /transl_table=11
FT                   /gene="tatD"
FT                   /locus_tag="Rv1008"
FT                   /standard_name="yjjV"
FT                   /product="PROBABLE DEOXYRIBONUCLEASE TATD (YJJV PROTEIN)"
FT                   /function="DNase INVOLVED IN PROTEINS EXPORT. THIS
FT                   SEC-INDEPENDENT PATHWAY IS TERMED TAT FOR TWIN-ARGININE
FT                   TRANSLOCATION SYSTEM. THIS SYSTEM MAINLY TRANSPORTS
FT                   PROTEINS WITH BOJ Biol Chem 2000;275:16717-16722UND
FT                   COFACTORS THAT REQUIRE FOLDING PRIOR TO EXPORT (BY
FT                   SIMILARITY)."
FT                   /EC_number="3.1.21.-"
FT                   /note="Rv1008, (MTCI237.25), len: 264 aa. Probable tatD
FT                   (alternate gene name: yjjV), deoxyribonuclease (EC
FT                   3.1.21.-), component of twin arginine translocation protein
FT                   export system (see citations below). Similar to many
FT                   members of the YBL055C/YJJV family e.g. YCFH_ECOLI|P37346
FT                   Putative deoxyribonuclease ycfH (EC 3.1.21.-) (265 aa),
FT                   fasta scores: opt: 487, E(): 1.4e-24, (36.7% identity in
FT                   270 aa overlap). Also similar to P37545|YABD_BACSU Putative
FT                   deoxyribonuclease yabD (255 aa), FASTA scores: opt: 599,
FT                   E(): 7.7e-33, (40.1% identity in 262 aa overlap). Contains
FT                   PS01137 Hypothetical YBL055c/yjjV family signature 1, and
FT                   PS01091 Hypothetical YBL055c/yjjV family signature 3."
FT                   /db_xref="GOA:O08343"
FT                   /db_xref="HSSP:1J6O"
FT                   /db_xref="InterPro:IPR018228"
FT                   /db_xref="UniProtKB/TrEMBL:O08343"
FT                   /inference="non-experimental evidence, no additional
FT                   details recorded"
FT                   /protein_id="CAB08135.1"
FT                   /translation="MVDAHTHLDACGARDADTVRSLVERAAAAGVTAVVTVADDLESAR
FT                   WVTRAAEWDRRVYAAVALHPTRADALTDAARAELERLVAHPRVVAVGETGIDMYWPGRL
FT                   DGCAEPHVQREAFAWHIDLAKRTGKPLMIHNRQADRDVLDVLRAEGAPDTVILHCFSSD
FT                   AAMARTCVDAGWLLSLSGTVSFRTARELREAVPLMPVEQLLVETDAPYLTPHPHRGLAN
FT                   EPYCLPYTVRALAELVNRRPEEVALITTSNARRAYGLGWMRQ"
FT   misc_feature    93302..93328
FT                   /note="PS01137 Hypothetical YBL055c/yjjV family signature
FT                   1"
FT   misc_feature    93881..93931
FT                   /note="PS01091 Hypothetical YBL055c/yjjV family signature
FT                   3"
FT   CDS             94304..95392
FT                   /transl_table=11
FT                   /gene="rpfB"
FT                   /locus_tag="Rv1009"
FT                   /product="Probable resuscitation-promoting factor rpfB"
FT                   /function="THOUGHT TO PROMOTE THE RESUSCITATION AND GROWTH
FT                   OF DORMANT, NONGROWING CELL. COULD ALSO STIMULATES THE
FT                   GROWTH OF SEVERAL OTHER HIGH G+C GRAM+ ORGANISMS, e.g.
FT                   Mycobacterium avium, Mycobacterium bovis (BCG),
FT                   Mycobacterium kansasii, Mycobacterium smegmatis."
FT                   /note="Rv1009, (MTCI237.26), len: 362 aa. Probable rpfB,
FT                   resuscitation-promoting factor (see citation below),
FT                   similar to others from Mycobacterium tuberculosis:
FT                   Rv2450c|MTV008.06c|RPFE PROBABLE RESUSCITATION-PROMOTING
FT                   FACTOR (172 aa), FASTA scores: E(): 1.9e-19, (42.9%
FT                   identity in 147 aa overlap); Rv0867c|RPFA, Rv1884c|RPFC,
FT                   and Rv2389c|RPFD. Possible lipoprotein; contains PS00013
FT                   Prokaryotic membrane lipoprotein lipid attachment site."
FT                   /db_xref="GOA:O05594"
FT                   /db_xref="InterPro:IPR011098"
FT                   /db_xref="PDB:1XSF"
FT                   /db_xref="UniProtKB/TrEMBL:O05594"
FT                   /protein_id="CAB08136.1"
FT                   /translation="MLRLVVGALLLVLAFAGGYAVAACKTVTLTVDGTAMRVTTMKSRV
FT                   IDIVEENGFSVDDRDDLYPAAGVQVHDADTIVLRRSRPLQISLDGHDAKQVWTTASTVD
FT                   EALAQLAMTDTAPAAASRASRVPLSGMALPVVSAKTVQLNDGGLVRTVHLPAPNVAGLL
FT                   SAAGVPLLQSDHVVPAATAPIVEGMQIQVTRNRIKKVTERLPLPPNARRVEDPEMNMSR
FT                   EVVEDPGVPGTQDVTFAVAEVNGVETGRLPVANVVVTPAHEAVVRVGTKPGTEVPPVID
FT                   GSIWDAIAGCEAGGNWAINTGNGYYGGVQFDQGTWEANGGLRYAPRADLATREEQIAVA
FT                   EVTRLRQGWGAWPVCAARAGAR"
FT   misc_feature    94343..94375
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             95365..96318
FT                   /transl_table=11
FT                   /gene="ksgA"
FT                   /locus_tag="Rv1010"
FT                   /product="PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA
FT                   (S-adenosylmethionine-6-N', N'-adenosyl(rRNA)
FT                   dimethyltransferase) (16S rRNA dimethylase) (High level
FT                   kasugamycin resistance protein ksgA) (Kasugamycin
FT                   dimethyltransferase)"
FT                   /function="SPECIFICALLY DIMETHYLATES TWO ADJACENT
FT                   ADENOSINES IN THE LOOP OF A CONSERVED HAIRPIN NEAR THE
FT                   3'-END OF 16S RRNA IN THE 30S PARTICLE. ITS INACTIVATION
FT                   LEADS TO KASUGAMYCIN RESISTANCE"
FT                   /EC_number="2.1.1.-"
FT                   /note="Rv1010, (MTCI237.27), len: 317 aa. Probable ksgA,
FT                   dimethyladenosine transferase (EC 2.1.1.-), similar to many
FT                   e.g. KSGA_BACSU|P37468 dimethyladenosine transferase from
FT                   Bacillus subtilus (292 aa), FASTA scores: opt: 524, E():
FT                   1.5e-28, (37.2% identity in 274 aa overlap); similar to
FT                   Mycobacterium tuberculosis hypothetical protein Rv1988.
FT                   Contains PS01131 Ribosomal RNA adenine dimethylases
FT                   signature."
FT                   /db_xref="GOA:P66660"
FT                   /db_xref="InterPro:IPR011530"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66660"
FT                   /protein_id="CAB08137.1"
FT                   /translation="MCCTSGCALTIRLLGRTEIRRLAKELDFRPRKSLGQNFVHDANTV
FT                   RRVVAASGVSRSDLVLEVGPGLGSLTLALLDRGATVTAVEIDPLLASRLQQTVAEHSHS
FT                   EVHRLTVVNRDVLALRREDLAAAPTAVVANLPYNVAVPALLHLLVEFPSIRVVTVMVQA
FT                   EVAERLAAEPGSKEYGVPSVKLRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYETSP
FT                   WPTDDAFRRRVFELVDIAFAQRRKTSRNAFVQWAGSGSESANRLLAASIDPARRGETLS
FT                   IDDFVRLLRRSGGSDEATSTGRDARAPDISGHASAS"
FT   misc_feature    95542..95625
FT                   /note="PS01131 Ribosomal RNA adenine dimethylases
FT                   signature"
FT   CDS             96404..97324
FT                   /transl_table=11
FT                   /gene="ispE"
FT                   /locus_tag="Rv1011"
FT                   /product="Probable
FT                   4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ISPE
FT                   (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
FT                   kinase)"
FT                   /function="THOUGHT TO BE INVOLVED IN
FT                   DEOXYXYLULOSE-5-PHOSPHATE PATHWAY (DXP) OF ISOPRENOID
FT                   BIOSYNTHESIS (AT THE FOURTH STEP). CATALYZES THE
FT                   PHOSPHORYLATION OF THE POSITION 2 HYDROXY GROUP OF
FT                   4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL [CATALYTIC
FT                   ACTIVITY: ATP + 4-(cytidine
FT                   5'-diphospho)-2-C-methyl-D-erythritol = ADP +
FT                   2-phospho-4-(cytidine
FT                   5'-diphospho)-2-C-methyl-D-erythritol]."
FT                   /EC_number="2.7.1.148"
FT                   /note="Rv1011, (MTCI237.28, MT1040), len: 306 aa. Probable
FT                   ispE, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC
FT                   2.7.1.148), similar to others e.g. Q9K3R6|ISPE_STRCO
FT                   Streptomyces coelicolor (299 aa), FASTA scores: opt: 925,
FT                   E(): 2.7e-49, (54.5% identity in 297 overlap); etc. BELONGS
FT                   TO THE ISPE FAMILY."
FT                   /db_xref="GOA:P65178"
FT                   /db_xref="InterPro:IPR014721"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65178"
FT                   /protein_id="CAB08138.1"
FT                   /translation="MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVT
FT                   VRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMA
FT                   GGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVL
FT                   SRNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLL
FT                   GNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGA
FT                   GVCRTVRVATGPVPGARVVSAPTEV"
FT   CDS             97341..97634
FT                   /transl_table=11
FT                   /locus_tag="Rv1012"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1012, (MTCI237.29), len: 97 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O05597"
FT                   /protein_id="CAB08139.1"
FT                   /translation="MPRAARGIRACRGRWVDRLAHQHASGRAAGIRPREVGGAHQSQAQ
FT                   KPYHDATEPLGESLRYRPAHGDSCINGHRDNPSARESSQFTAGSTAKAVTKL"
FT   CDS             97838..99472
FT                   /transl_table=11
FT                   /gene="pks16"
FT                   /locus_tag="Rv1013"
FT                   /product="PUTATIVE POLYKETIDE SYNTHASE PKS16"
FT                   /function="POTENTIALLY INVOLVED IN SOME INTERMEDIATE STEPS
FT                   FOR THE SYNTHESIS OF A POLYKETIDE MOLECULE WHICH MAY BE
FT                   INVOLVED IN SECONDARY METABOLISM."
FT                   /note="Rv1013, (MTCI237.30-MTCY10G2.36c), len: 544 aa.
FT                   Putative pks16, polyketide synthase, similar to many e.g.
FT                   N-terminus of Q50857|U24657 SAFRAMYCIN MX1 SYNTHETASE B
FT                   (1770 aa), FASTA scores: opt: 526, E(): 1.4e-25, (29.3%
FT                   identity in 542 aa overlap); etc. Contains PS00455 Putative
FT                   AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT
FT                   AMP-BINDING ENZYME FAMILY."
FT                   /db_xref="GOA:O05598"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="UniProtKB/TrEMBL:O05598"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB08159.1"
FT                   /translation="MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGG
FT                   LAAAGVGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAEDTMTVI
FT                   GMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEVGEDDLALMQLTSGS
FT                   TGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVSWLPCFHDMGMVGFLTIPMFFGAE
FT                   LVKVTPMDFLRDTLLWAKLIDKYQGTMTAAPNFAYALLAKRLRRQAKPGDFDLSTLRFA
FT                   LSGAEPVEPADVEDLLDAGKPFGLRPSAILPAYGMAETTLAVSFSECNAGLVVDEVDAD
FT                   LLAALRRAVPATKGNTRRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESLTPG
FT                   YLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNIYPTDIERAAGR
FT                   VDGVRPGCAVAVRLDAGHSRESFAVAVESNAFEDPAEVRRIEHQVAHEVVAEVDVRPRN
FT                   VVVLGPGTIPKTPSGKLRRANSVTLVT"
FT   misc_feature    98306..98341
FT                   /note="PS00455 Putative AMP-binding domain signature"
FT   CDS             complement(99546..100121)
FT                   /transl_table=11
FT                   /gene="pth"
FT                   /locus_tag="Rv1014c"
FT                   /product="PROBABLE PEPTIDYL-TRNA HYDROLASE PTH"
FT                   /function="THE NATURAL SUBSTRATE FOR THIS ENZYME MAY BE
FT                   PEPTIDYL-TRNAS WHICH DROP OFF THE RIBOSOME DURING PROTEIN
FT                   SYNTHESIS [CATALYTIC ACTIVITY : N-SUBSTITUTED
FT                   AMINOACYL-TRNA + H(2)O = N-SUBSTITUTED AMINO ACID + TRNA]"
FT                   /EC_number="3.1.1.29"
FT                   /note="Rv1014c, (MTCY10G2.35), len: 191 aa. Probable pth,
FT                   peptidyl-tRNA hydrolase (EC 3.1.1.29), similar to
FT                   PTH_ECOLI|P23932 peptidy l-trna hydrolase from Escherichia
FT                   coli (194 aa), FASTA scores: opt: 472, E(): 2.3e-25, (39.6%
FT                   identity in 187 aa overlap). BELONGS TO THE PTH FAMILY."
FT                   /db_xref="GOA:P65865"
FT                   /db_xref="InterPro:IPR018171"
FT                   /db_xref="PDB:2JRC"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65865"
FT                   /protein_id="CAB06865.1"
FT                   /translation="MAEPLLVVGLGNPGANYARTRHNLGFVVADLLAARLGAKFKAHKR
FT                   SGAEVATGRSAGRSLVLAKPRCYMNESGRQIGPLAKFYSVAPANIIVIHDDLDLEFGRI
FT                   RLKIGGGEGGHNGLRSVVAALGTKDFQRVRIGIGRPPGRKDPAAFVLENFTPAERAEVP
FT                   TICEQAADATELLIEQGMEPAQNRVHAW"
FT   CDS             complement(100134..100781)
FT                   /transl_table=11
FT                   /gene="rplY"
FT                   /locus_tag="Rv1015c"
FT                   /product="PROBABLE 50S RIBOSOMAL PROTEIN L25 RPLY"
FT                   /function="BINDS TO THE 50S RRNA"
FT                   /note="Rv1015c, (MTCY10G2.34), len: 215 aa. Probable rplY,
FT                   50s ribosomal protein L25, similar to RL25_ECOLI|P02426 50s
FT                   ribosomal protein L25 from Escherichia coli (94 aa), FASTA
FT                   scores: opt: 182, E(): 2.5e-05, (38.4% identity in 86 aa
FT                   overlap) and to CTC_BACSU|P14194 general stress protein
FT                   from Bacillus subtilis (203 aa), FASTA scores: opt: 260,
FT                   E(): 1.4e-09, (28.4% identity in 201 aa overlap). BELONGS
FT                   TO THE L25P FAMILY OF RIBOSOMAL PROTEINS."
FT                   /db_xref="GOA:P66121"
FT                   /db_xref="HSSP:1DFU"
FT                   /db_xref="InterPro:IPR020055"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66121"
FT                   /protein_id="CAB06864.1"
FT                   /translation="MAKSASNQLRVTVRTETGKGASRRARRAGKIPAVLYGHGAEPQHL
FT                   ELPGHDYAAVLRHSGTNAVLTLDIAGKEQLALTKALHIHPIRRTIQHADLLVVRRGEKV
FT                   VVEVSVVVEGQAGPDTLVTQETNSIEIEAEALSIPEQLTVSIEGAEPGTQLTAGQIALP
FT                   AGVSLISDPDLLVVNVVKAPTAEELEGEVAGAEEAEEAAVEAGEAEAAGESE"
FT   CDS             complement(100998..101678)
FT                   /transl_table=11
FT                   /gene="lpqT"
FT                   /locus_tag="Rv1016c"
FT                   /product="PROBABLE CONSERVED LIPOPROTEIN LPQT"
FT                   /function="UNKNOWN"
FT                   /note="Rv1016c, (MTCY10G2.33), len: 226 aa. Probable lpqT,
FT                   conserved lipoprotein. Similar to several Mycobacterium
FT                   tuberculosis hypothetical proteins e.g.
FT                   Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA antigen (310
FT                   aa), FASTA scores: opt: 329, E(): 2e-17, (32.3% identity in
FT                   229 aa overlap); Rv0583c. Contains PS00013 Prokaryotic
FT                   membrane lipoprotein lipid attachment site."
FT                   /db_xref="GOA:P96384"
FT                   /db_xref="InterPro:IPR019674"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96384"
FT                   /protein_id="CAB06863.1"
FT                   /translation="MAGRRCPQDSVRPLAVAVAVATLAMSAVACGPKSPDFQSILSTSP
FT                   TTSAVSTTTEVPVPLWKYLESVGVTGEPVAPSSLTDLTVSIPTPPGWAPMKNPNITPNT
FT                   EMIAKGESYPTAMLMVFKLHRDFDIAEALKHGTADARLSTNFTELDSSTADFNGFPSSM
FT                   IQGSYDLHGRRLHTWNRIVFPTGAPPAKQRYLVQLTITSLANEAVKHASDIEAIIAGFV
FT                   VAAK"
FT   misc_feature    complement(101589..101621)
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             complement(101714..102694)
FT                   /transl_table=11
FT                   /gene="prsA"
FT                   /locus_tag="Rv1017c"
FT                   /product="PROBABLE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE PRSA
FT                   (Phosphoribosyl pyrophosphate synthetase) (PRPP
FT                   synthetase)"
FT                   /function="Catalyzes the formation of PRPP from ATP and
FT                   ribose 5-phosphate. PRPP is then used in various
FT                   biosynthetic pathways, as for example in the formation of
FT                   purines, pyrimidines, histidine and tryptophan. [CATALYTIC
FT                   ACTIVITY: ATP + D-ribose 5-phosphate = AMP +
FT                   5-phospho-alpha-D-ribose 1-diphosphate]"
FT                   /EC_number="2.7.6.1"
FT                   /note="Rv1017c, (MTCY10G2.32), len: 326 aa. Probable prsA,
FT                   ribose-phosphate pyrophosphokinase (EC 2.7.6.1), highly
FT                   similar to others e.g. KPRS_ECOLI|P08330 ribose-phosphate
FT                   pyrophosphokinase from Escherichia coli (314 aa), FASTA
FT                   scores: opt: 826, E(): 0, (43.8% identity in 317 aa
FT                   overlap). Contains PS00103 Purine/pyrimidine phosphoribosyl
FT                   transferases signature; contains PS00144 Asparaginase /
FT                   glutaminase active site signature 1. BELONGS TO THE
FT                   RIBOSE-PHOSPHATE PYROPHOSPHOKINASE FAMILY. COFACTOR: BOTH
FT                   INORGANIC PHOSPHATE AND MAGNESIUM ION ARE REQUIRED FOR
FT                   ENZYME STABILITY AND ACTIVITY (by similarity)."
FT                   /db_xref="GOA:P65232"
FT                   /db_xref="HSSP:1DKR"
FT                   /db_xref="InterPro:IPR005946"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65232"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06862.1"
FT                   /translation="MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFAN
FT                   GEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPYAR
FT                   QDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYI
FT                   RDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVA
FT                   GRTCVLIDDMIDTGGTIAGAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIV
FT                   TNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTGLFDGDA"
FT   misc_feature    complement(101975..102001)
FT                   /note="PS00144 Asparaginase / glutaminase active site
FT                   signature 1"
FT   misc_feature    complement(101981..102019)
FT                   /note="PS00103 Purine/pyrimidine phosphoribosyl
FT                   transferases signature"
FT   CDS             complement(102786..104273)
FT                   /transl_table=11
FT                   /gene="glmU"
FT                   /locus_tag="Rv1018c"
FT                   /product="Probable UDP-N-acetylglucosamine
FT                   pyrophosphorylase glmU"
FT                   /function="PEPTIDOGLYCAN AND LIPOPOLYSACCHARIDE
FT                   BIOSYNTHESIS"
FT                   /EC_number="2.7.7.23"
FT                   /note="Rv1018c, (MTCY10G2.31), len: 495 aa. Probable glmU,
FT                   UDP-n-acetylglucosamine pyrophosphorylase (EC 2.7.7.23),
FT                   similar to GCAD_BACSU|P14192 UDP-n-acetylglucosamine
FT                   pyrophosphorylase (456 aa), FASTA scores: opt: 1150, E():
FT                   0, (40.0% identity in 453 aa overlap). Similar to various
FT                   Mycobacterium tuberculosis sugar-phosphate transferases
FT                   e.g. Rv0334, Rv1213, Rv3264c, etc."
FT                   /db_xref="GOA:P96382"
FT                   /db_xref="InterPro:IPR005882"
FT                   /db_xref="PDB:2QKX"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96382"
FT                   /protein_id="CAB06861.1"
FT                   /translation="MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIA
FT                   KLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDY
FT                   AGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEVMA
FT                   IVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQ
FT                   TVHASHVDDSALVAGVNNRVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIG
FT                   RDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPF
FT                   TYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYD
FT                   GTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIE
FT                   NWVQRKRPGSPAAQASKRASEMACQQPTQPPDADQTP"
FT   tRNA            complement(104289..104360)
FT                   /gene="tRNA-Gln(TTG)"
FT                   /product="transfer RNA-Gln(TTG)"
FT                   /anticodon=(pos:104325..104327,aa:Gln)
FT   CDS             104528..105121
FT                   /transl_table=11
FT                   /locus_tag="Rv1019"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT                   (PROBABLY TETR-FAMILY)"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT                   /note="Rv1019, (MTCY10G2.30c), len: 197 aa. Probable
FT                   transcriptional regulator, similar to many memebers of the
FT                   tetR family e.g. MTCY7D11.18c (34.4% identity in 189 aa
FT                   overlap). Helix turn helix motif from aa 27-48 (+5.42 SD)."
FT                   /db_xref="GOA:P96381"
FT                   /db_xref="InterPro:IPR012287"
FT                   /db_xref="UniProtKB/TrEMBL:P96381"
FT                   /protein_id="CAB06860.1"
FT                   /translation="MTGTERRHQLIGIARSLFAERGYDGTSIEEIAQRANVSKPVVYEH
FT                   FGGKEGLYAVVVDREMSALLDGITSSLTNNRSRVRVERVALALLTYVEERTDGFRIMIR
FT                   DSPASISSGTYSSLLNDAVSQVSSILAGDFARRGLDPDLAPLYAQALVGSVSMTAQWWL
FT                   DAREPKKEVVAAHLVNLVWNGLTHLEADPRLQDE"
FT   CDS             105180..108884
FT                   /transl_table=11
FT                   /gene="mfd"
FT                   /locus_tag="Rv1020"
FT                   /standard_name="trcF"
FT                   /product="PROBABLE TRANSCRIPTION-REPAIR COUPLING FACTOR MFD
FT                   (TRCF)"
FT                   /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR.
FT                   NECESSARY FOR STRAND-SPECIFIC REPAIR. A LESION IN THE
FT                   TEMPLATE STRAND BLOCKS THE RNA POLYMERASE COMPLEX (RNAP).
FT                   THE RNAP-DNA-RNA COMPLEX IS SPECIFICALLY RECOGNIZED BY TRCF
FT                   WHICH RELEASES RNAP AND THE TRUNCATED TRANSCRIPT; THE TCRF
FT                   MAY REPLACE RNAP AT THE LESION SITE AND THEN RECRUIT THE
FT                   UVRA/B/C REPAIR SYSTEM."
FT                   /note="Rv1020, (MTCY10G2.29c), len: 1234 aa. Probable mfd
FT                   (alternate gene name: trcF), transcription-repair coupling
FT                   factor (see citation below), similar to many e.g.
FT                   MFD_ECOLI|P30958 transcription-repair coupling factor from
FT                   Escherichia coli (1148 aa), FASTA scores: opt: 1900, E():
FT                   0, (37.9% identity in 1107 aa overlap); similar to M.
FT                   tuberculosis Rv2973c and Rv1633. Contains PS00017
FT                   ATP/GTP-binding site motif A (P-loop). IN THE N-TERMINAL
FT                   SECTION; BELONGS TO THE UVRB FAMILY. IN THE C-TERMINAL
FT                   SECTION; BELONGS TO THE HELICASE FAMILY. RECG SUBFAMILY."
FT                   /db_xref="GOA:P64326"
FT                   /db_xref="HSSP:1D9X"
FT                   /db_xref="InterPro:IPR005118"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64326"
FT                   /protein_id="CAB06859.1"
FT                   /translation="MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAP
FT                   ASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLSPG
FT                   VDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESP
FT                   FDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFS
FT                   VADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLA
FT                   EGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEAS
FT                   WSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVR
FT                   AAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPG
FT                   QAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLA
FT                   LTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSL
FT                   DQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPDT
FT                   PWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAV
FT                   QDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVD
FT                   IVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLE
FT                   MSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLRDGQAFYVHNRVSSID
FT                   AAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILVCTTIVETGLDISNANT
FT                   LIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGA
FT                   GMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVR
FT                   TAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGAL
FT                   PEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRA
FT                   TTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAGKPRQHIGITNPSPPGEDGRGR
FT                   NTTIKERQP"
FT   misc_feature    107205..107228
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             108884..109861
FT                   /transl_table=11
FT                   /locus_tag="Rv1021"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1021, (MTCY10G2.28c), len: 325 aa. Conserved
FT                   hypothetical protein, similar to YBL1_STRCI|P33653
FT                   hypothetical 26.1 kDa protein from Streptomyces cacaoi (242
FT                   aa), FASTA scores: opt: 493, E(): 1.1e-23, (42.9% identity
FT                   in 238 aa overlap)."
FT                   /db_xref="InterPro:IPR004518"
FT                   /db_xref="UniProtKB/TrEMBL:P96379"
FT                   /protein_id="CAB06858.1"
FT                   /translation="MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARS
FT                   AHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWE
FT                   SEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTI
FT                   DDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALAL
FT                   AQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVAR
FT                   RGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR"
FT   CDS             109949..110680
FT                   /transl_table=11
FT                   /gene="lpqU"
FT                   /locus_tag="Rv1022"
FT                   /product="PROBABLE CONSERVED LIPOPROTEIN LPQU"
FT                   /function="UNKNOWN"
FT                   /note="Rv1022, (MTCY10G2.27c), len: 243 aa. Probable lpqU
FT                   conserved lipoprotein. Similar to Mycobacterium
FT                   tuberculosis hypothetical protein Rv1230c|MTV006.02C, FASTA
FT                   scores: E(): 2.8e-18, (37.9% identity in 240 aa overlap).
FT                   Similar to AL133423|SC4A7.37 hypothetical protein from
FT                   Streptomyces coelicolor (421 aa), FASTA scores: opt: 474,
FT                   E(): 2.7e-21, (42.2% identity in 211 aa overlap). Contains
FT                   PS00013 Prokaryotic membrane lipoprotein lipid attachment
FT                   site."
FT                   /db_xref="UniProtKB/TrEMBL:P96378"
FT                   /protein_id="CAB06857.1"
FT                   /translation="MSPRRWLRAVAVIGATAMLLASSCTWQLSLFITDGVPPPPGDPVP
FT                   PVDTHAGGRPADQLREWAEKRAAALGIPVIALEAYAYAARVAEVENPKCHLAWTTLAGI
FT                   GRVESHHGTYRGATIAPNGDVSPPIRGVRLDGTGGTLRIVDRDGGGLDGDAAVERAMGP
FT                   MQFISETWRLYGVAARNDGIANVDNIDDAALSAAGYLCWRGKDLATPRGWITALRAYNN
FT                   SVIYARAVRDWATAYAAGHPL"
FT   misc_feature    109988..110020
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             110777..112066
FT                   /transl_table=11
FT                   /gene="eno"
FT                   /locus_tag="Rv1023"
FT                   /product="PROBABLE ENOLASE ENO"
FT                   /function="GLYCOLYSIS [CATALYTIC
FT                   ACTIVITY:2-PHOSPHO-D-GLYCERATE = PHOSPHOENOLPYRUVATE +
FT                   H(2)O]"
FT                   /EC_number="4.2.1.11"
FT                   /note="Rv1023, (MTCY10G2.26c), len: 429 aa. Probable eno,
FT                   enolase (EC 4.2.1.11), highly similar to others e.g.
FT                   ENO_ECOLI|P08324 enolase from Escherichia coli (431 aa),
FT                   FASTA scores: opt: 1487, E(): 0, (55.5% identity in 422 aa
FT                   overlap); etc. MAGNESIUM IS REQUIRED FOR CATALYSIS AND FOR
FT                   STABILIZING THE DIMER. BELONGS TO THE ENOLASE FAMILY."
FT                   /db_xref="GOA:P96377"
FT                   /db_xref="HSSP:1OEP"
FT                   /db_xref="InterPro:IPR000941"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96377"
FT                   /protein_id="CAB06856.1"
FT                   /translation="MPIIEQVRAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGE
FT                   HEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSR
FT                   LGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDIQE
FT                   FMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLIS
FT                   RAIESAGLRPGADVALALDAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVS
FT                   IEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERLEEGIERGVANALLVKVNQIG
FT                   TLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKY
FT                   NQLLRIEEALGDAARYAGDLAFPRFACETK"
FT   CDS             112071..112757
FT                   /transl_table=11
FT                   /locus_tag="Rv1024"
FT                   /product="POSSIBLE CONSERVED MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1024, (MTCY10G2.25c), len: 228 aa. Possible
FT                   conserved membrane protein, with a hydrophobic region from
FT                   aa 83-101. Equivalent to ML0256|NP_301311.1|NC_002677
FT                   POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium
FT                   leprae (227 aa), S&W scores: 178, E()= 2e-72, Identities:
FT                   145/203 (71%)."
FT                   /db_xref="GOA:P96376"
FT                   /db_xref="InterPro:IPR007060"
FT                   /db_xref="UniProtKB/TrEMBL:P96376"
FT                   /protein_id="CAB06855.1"
FT                   /translation="MPEAKRPESKRRSPASRPGKAGDSVRGGRATKPSAKPSTPAPHAS
FT                   RKTTRTPHEHIVEPIKRAITESVEKRSEQRLGFTARRAAILAAVVCVLTLTIARPVRTY
FT                   FAQRAEMEQLAATEAMLRRQIADLEEQQVKLADPAYIAAQARERLGFVMPGDIPFQVQL
FT                   PSTPLAPPQPGSDAATATNNEPWYTALWHTIADDPHLPPAAPPAPEPGRPGPLPPASPN
FT                   PEQPGG"
FT   CDS             112774..113241
FT                   /transl_table=11
FT                   /locus_tag="Rv1025"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1025, (MTCY10G2.24c), len: 155 aa. Conserved
FT                   hypothetical protein, similar to hypothetical protein
FT                   AE001768|AE001768_4 Thermotoga maritima (170 aa) FASTA
FT                   scores: opt: 254, E(): 9.5e-10, (35.7% identity in 143 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR007511"
FT                   /db_xref="UniProtKB/TrEMBL:P96375"
FT                   /protein_id="CAB06854.1"
FT                   /translation="MVTRQLGRAPRGVLAIAYRCPNGEPGVVKTAPRLPDGTPFPTLYY
FT                   LTHPVLTAAASRLETTGLMREMNRRLGQDAELAAAYRRAHESYLSERDALEPLGTTVSA
FT                   GGMPDRVKCLHVLIAHSLAKGPGLNPFGDEALALLAAEPRTAATLVAGQWR"
FT   CDS             113232..114191
FT                   /transl_table=11
FT                   /locus_tag="Rv1026"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN. COULD BE INVOLVED IN AN ADAPTIVE
FT                   PROCESS THAT ALLOWS BACTERIA TO RESPOND TO AMINO ACID
FT                   STARVATION."
FT                   /note="Rv1026, (MTCY10G2.23c), len: 319 aa. Conserved
FT                   hypothetical protein. Similar to GPPA_ECOLI|P25552
FT                   guanosine-5'-triphosphate,3'-diphosphate pyrophoshatase
FT                   from Escherichia coli (494 aa), FASTA scores: opt: 281,
FT                   E(): 3.2e-11, (30.6% identity in 291 aa overlap).
FT                   Equivalent to AL023514|MLCB4.02 hypothetical protein from
FT                   Mycobacterium leprae (317 aa) (77.9% identity in 321 aa
FT                   overlap)."
FT                   /db_xref="InterPro:IPR003695"
FT                   /db_xref="UniProtKB/TrEMBL:P96374"
FT                   /protein_id="CAB06853.1"
FT                   /translation="MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLG
FT                   QGVDATGRFAPEAIARTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTAD
FT                   VLGAALPGSAAEVITGAEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVA
FT                   SYSADIGCVRLTERCLHSDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTM
FT                   TTLSALAQSMTAYDAAAIHLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGG
FT                   GAIVVEELARELRERAGIDQLTVSEHDILDGIALSLAG"
FT   CDS             complement(114640..115320)
FT                   /transl_table=11
FT                   /gene="kdpE"
FT                   /locus_tag="Rv1027c"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN KDPE"
FT                   /function="MEMBER OF THE TWO-COMPONENT REGULATORY SYSTEM
FT                   KDPD/KDPE INVOLVED IN THE REGULATION OF THE KDP OPERON."
FT                   /note="Rv1027c, (MTCY10G2.22), len: 226 aa. Probable KdpE,
FT                   transcriptional regulatory protein, similar to others e.g.
FT                   KDPE_ECOLI|P21866 kdp operon transcriptional regulatory
FT                   protein from Escherichia coli strain K12 (225 aa), FASTA
FT                   scores: opt: 691, E(): 0, (47.8% identity in 224 aa
FT                   overlap); AL021530|SC2E9.13 from Streptomyces coelicolor
FT                   (227 aa), FASTA scores: opt: 981, E(): 0, (66.4% identity
FT                   in 226 aa overlap); etc."
FT                   /db_xref="GOA:P96373"
FT                   /db_xref="HSSP:1B00"
FT                   /db_xref="InterPro:IPR001867"
FT                   /db_xref="UniProtKB/TrEMBL:P96373"
FT                   /protein_id="CAB06852.1"
FT                   /translation="MTLVLVIDDEPQILRALRINLTVRGYQVITASTGAGALRAAAEHP
FT                   PDVVILDLGLPDMSGIDVLGGLRGWLTAPVIVLSARTDSSDKVQALDAGADDYVTKPFG
FT                   MDEFLARLRAAVRRNTAAAELEQPVIETDSFTVDLAGKKVIKDGAEVHLTPTEWGMLEM
FT                   LARNRGKLVGRGELLKEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGY
FT                   RFEA"
FT   CDS             complement(115317..117899)
FT                   /transl_table=11
FT                   /gene="kdpD"
FT                   /locus_tag="Rv1028c"
FT                   /product="PROBABLE SENSOR PROTEIN KDPD"
FT                   /function="MEMBER OF THE TWO-COMPONENT REGULATORY SYSTEM
FT                   KDPD/KDPE INVOLVED IN THE REGULATION OF THE KDP OPERON.
FT                   KDPD MAY FUNCTION AS A MEMBRANE-ASSOCIATED PROTEIN KINASE
FT                   THAT PHOSPHORYLATES KDPE|Rv1027c IN RESPONSE TO
FT                   ENVIRONMENTAL SIGNALS."
FT                   /EC_number="2.7.3.-"
FT                   /note="Rv1028c, (MTCY10G2.21), len: 860 aa. Probable kdpD,
FT                   sensor protein (EC 2.7.3.-), similar to others e.g.
FT                   KDPD_ECOLI|P21865 sensor protein from Escherichia coli
FT                   strain K12 (894 aa), FASTA scores: opt: 1041, E(): 0,
FT                   (32.3% identity in 888 aa overlap); etc. Contains PS00017
FT                   ATP/GTP-binding site motif A (P-loop)."
FT                   /db_xref="GOA:P96372"
FT                   /db_xref="InterPro:IPR003594"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96372"
FT                   /protein_id="CAB06851.1"
FT                   /translation="MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAM
FT                   LGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIEMIPPRYVEYRGARFPELDVEAVLR
FT                   RHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITG
FT                   IEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTAL
FT                   REIALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKS
FT                   SAELMVVHVIRGDGLAGVSAPQLGRVRELATSLGATMHTVVGDDVPTALLDFAREMNAT
FT                   QLVVGTSRRSRWARLFDEGIGARTVQEPGGIDVHMVTHPAASRASGWSRVSPRERHIAS
FT                   WLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLL
FT                   NYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVLVDGAASRTREARRASQEAELLALF
FT                   AGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVACVGTNPCRDVDSADTAI
FT                   EVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRS
FT                   LLSAVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESIDQLTALVANLLDS
FT                   SRLAAGVIRPQLRRAYLEEAVQRALVSIGKGATGFYRSGIDRVKVDVGDAVAMADAGLL
FT                   ERVLANLIDNALRYAPDCVVRVNAGRVRERVLINVIDEGPGVPRGTEEQLFAPFQRPGD
FT                   HDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP"
FT   misc_feature    complement(117774..117797)
FT                   /note="PS00017 ATP/GTP-binding site motif A"
FT   CDS             118133..118225
FT                   /transl_table=11
FT                   /gene="kdpF"
FT                   /locus_tag="Rv1028A"
FT                   /product="Probable membrane protein kdpF"
FT                   /function="THOUGHT TO BE INVOLVED IN STABILIZATION OF THE
FT                   KDP COMPLEX."
FT                   /note="Rv1028A, len: 30 aa. Probable kdpF, membrane
FT                   protein, showing similarity with P36937|KDPF_ECOLI|B0698.1
FT                   PROTEIN KDPF from Escherichia coli strain K12 (see citation
FT                   below) (27% identity); and KdpF protein from Streptomyces
FT                   coelicolor (51% identity)."
FT                   /db_xref="InterPro:IPR011726"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FT7"
FT                   /protein_id="CAE55348.1"
FT                   /translation="MTTVDNIVGLVIAVALMAFLFAALLFPEKF"
FT   CDS             118225..119940
FT                   /transl_table=11
FT                   /gene="kdpA"
FT                   /locus_tag="Rv1029"
FT                   /product="Probable Potassium-transporting ATPase A chain
FT                   KDPA (Potassium-translocating ATPase A chain) (ATP
FT                   phosphohydrolase [potassium-transporting] A chain)
FT                   (Potassium binding and translocating subunit A)"
FT                   /function="ONE OF THE COMPONENTS OF THE HIGH-AFFINITY
FT                   ATP-DRIVEN POTASSIUM TRANSPORT (OR KDP) SYSTEM, WHICH
FT                   CATALYZES THE HYDROLYSIS OF ATP COUPLED WITH THE EXCHANGE
FT                   OF HYDROGEN AND POTASSIUM IONS [CATALYTIC ACTIVITY: ATP +
FT                   H(2)O + K(+)(OUT) = ADP + PHOSPHATE + K(+)(IN)]."
FT                   /EC_number="3.6.3.12"
FT                   /note="Rv1029, (MTCY10G2.20c), len: 571 aa. Probable kdpA,
FT                   potassium-transporting ATPase A chain (transmembrane
FT                   protein) (EC 3.6.3.12), similar to others e.g.
FT                   ATKA_ECOLI|P03959|KDPA|B0698 potassium-transporting ATPase
FT                   A chain from Escherichia coli strain K12 (557 aa), FASTA
FT                   scores: opt: 1763, E(): 0, (50.4% identity in 569 aa
FT                   overlap); etc. BELONGS TO THE KDPA FAMILY."
FT                   /db_xref="GOA:P65209"
FT                   /db_xref="InterPro:IPR004623"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65209"
FT                   /protein_id="CAB06850.1"
FT                   /translation="MSGTSWLQFAALIAVLLLTAPALGGYLAKIYGDEAKKPGDRVFGP
FT                   IERVIYQVCRVDPGSEQRWSTYALSVLAFSVMSFLLLYGIARFQGVLPFNPTDKPAVTD
FT                   HVAFNAAVSFMTNTNWQSYSGEATMSHFTQMTGLAVQNFVSASAGMCVLAALIRGLARK
FT                   RASTLGNFWVDLARTVLRIMFPLSFVVAILLVSQGVIQNLHGFIVANTLEGAPQLIPGG
FT                   PVASQVAIKQLGTNGGGFFNVNSAHPFENYTPIGNFVENWAILIIPFALCFAFGKMVHD
FT                   RRQGWAVLAIMGIIWIGMSVAAMSFEAKGNPRLDALGVTQQTTVDQSGGNLEGKEVRFG
FT                   VGASGLWAASTTGTSNGSVNSMHDSYTPLGGMVPLAHMMLGEVSPGGTGVGLNGLLVMA
FT                   ILAVFIAGLMVGRTPEYLGKKIQATEMKLVTLYILAMPIALLSFAAASVLISSALASRN
FT                   NPGPHGLSEILYAYTSGANNNGSAFAGLTASTWSYDTTIGVAMLIGRFFLIIPVLAIAG
FT                   SLARKGTTPVTAATFPTHKPLFVGLVIGVVLIVGGLTFFPALALGPIVEQLSTQ"
FT   CDS             119937..122066
FT                   /transl_table=11
FT                   /gene="kdpB"
FT                   /locus_tag="Rv1030"
FT                   /product="Probable Potassium-transporting P-type ATPase B
FT                   chain KDPB (Potassium-translocating ATPase B chain) (ATP
FT                   phosphohydrolase [potassium-transporting] B chain)
FT                   (Potassium binding and translocating subunit B)"
FT                   /function="ONE OF THE COMPONENTS OF THE HIGH-AFFINITY
FT                   ATP-DRIVEN POTASSIUM TRANSPORT (OR KDP) SYSTEM, WHICH
FT                   CATALYZES THE HYDROLYSIS OF ATP COUPLED WITH THE EXCHANGE
FT                   OF HYDROGEN AND POTASSIUM IONS [CATALYTIC ACTIVITY:ATP +
FT                   H(2)O + K(+)(OUT) = ADP + PHOSPHATE + K(+)(IN)]."
FT                   /EC_number="3.6.3.12"
FT                   /note="Rv1030, (MTCY10G2.19c), len: 709 aa. Probable kdpB,
FT                   potassium-transporting P-type ATPase B chain (transmembrane
FT                   protein) (EC3.6.3.12), similar to others e.g.
FT                   ATKB_ECOLI|P03960 potassium-transporting ATPase B chain
FT                   from Escherichia coli strain K12 (682 aa), FASTA scores:
FT                   opt: 1481, E(): 0, (63.4% identity in 686 aa overlap); etc.
FT                   Very similar to AL078610|SCH35.47 H+/K+-exchanging ATPase
FT                   (EC 3.6.1.36) chain B from Streptomyces coelicolor (707
FT                   aa), FASTA scores: opt: 2731, E(): 0, (71.6% identity in
FT                   676 aa overlap). Contains PS00154 E1-E2 ATPases
FT                   phosphorylation site."
FT                   /db_xref="GOA:P63681"
FT                   /db_xref="InterPro:IPR005834"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63681"
FT                   /protein_id="CAB06849.1"
FT                   /translation="MMIARMETSATAAAATSAPRLRLAKRSLFDPMIVRSALPQSLRKL
FT                   APRVQARNPVMLVVLVGAVITTLAFLRDLASSTAQENVFNGLVAAFLWFTVLFANFAEA
FT                   MAEGRGKAQAAALRKVRSETMANRRTAAGNIESVPSSRLDLDDVVEVSAGETIPSDGEI
FT                   IEGIASVDESAITGESAPVIRESGGDRSAVTGGTVVLSDRIVVRITAKQGQTFIDRMIA
FT                   LVEGAARQQTPNEIALNILLAGLTIIFLLAVVTLQPFAIYSGGGQRVVVLVALLVCLIP
FT                   TTIGALLSAIGIAGMDRLVQHNVLATSGRAVEAAGDVNTLLLDKTGTITLGNRQATEFV
FT                   PINGVSAEAVADAAQLSSLADETPEGRSIVVLAKDEFGLRARDEGVMSHARFVPFTAET
FT                   RMSGVDLAEVSGIRRIRKGAAAAVMKWVRDHGGHPTEEVGAIVDGISSGGGTPLVVAEW
FT                   TDNSSARAIGVVHLKDIVKVGIRERFDEMRRMSIRTVMITGDNPATAKAIAQEAGVDDF
FT                   LAEATPEDKLALIKREQQGGRLVAMTGDGTNDAPALAQADVGVAMNTGTQAAREAGNMV
FT                   DLDSDPTKLIEVVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFVGLYPVLDKLNVM
FT                   ALHSPRSAILSAVIFNALVIVALIPLALRGVRFRAESASAMLRRNLLIYGLGGLVVPFI
FT                   GIKLVDLVIVALGVS"
FT   misc_feature    120906..120926
FT                   /note="PS00154 E1-E2 ATPases phosphorylation site"
FT   CDS             122066..122635
FT                   /transl_table=11
FT                   /gene="kdpC"
FT                   /locus_tag="Rv1031"
FT                   /product="Probable Potassium-transporting ATPase C chain
FT                   KDPC (Potassium-translocating ATPase C chain) (ATP
FT                   phosphohydrolase [potassium-transporting] C chain)
FT                   (Potassium binding and translocating subunit C)"
FT                   /function="ONE OF THE COMPONENTS OF THE HIGH-AFFINITY
FT                   ATP-DRIVEN POTASSIUM TRANSPORT (OR KDP) SYSTEM, WHICH
FT                   CATALYZES THE HYDROLYSIS OF ATP COUPLED WITH THE EXCHANGE
FT                   OF HYDROGEN AND POTASSIUM IONS. THE C SUBUNIT MAY BE
FT                   INVOLVED IN ASSEMBLY OF THE KDP COMPLEX. [CATALYTIC
FT                   ACTIVITY: ATP + H(2)O + K(+)(OUT) = ADP + PHOSPHATE +
FT                   K(+)(IN)]."
FT                   /EC_number="3.6.3.12"
FT                   /note="Rv1031, (MTCY10G2.18c), len: 189 aa. Probable kdpC,
FT                   potassium-transporting ATPase C chain (membrane protein)
FT                   (EC 3.6.3.12), similar to others e.g. ATKC_ECOLI|P03961
FT                   potassium-transporting ATPase C chain from Escherichia coli
FT                   strain K12 (190 aa), FASTA scores: opt: 475, E(): 3.1e-24,
FT                   (45.7% identity in 186 aa overlap); etc. BELONGS TO THE
FT                   KDPC FAMILY."
FT                   /db_xref="GOA:P65211"
FT                   /db_xref="InterPro:IPR003820"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65211"
FT                   /protein_id="CAB06848.1"
FT                   /translation="MRRQLLPALTMLLVFTVITGIVYPLAVTGVGQLFFGDQANGALLE
FT                   RDGQVIGSAHIGQQFTAAKYFHPRPSSAGDGYDAAASSGSNLGPTNEKLLAAVAERVTA
FT                   YRKENNLPADTLVPVDAVTGSGSGLDPAISVVNAKLQAPRVAQARNISIRQVERLIEDH
FT                   TDARGLGFLGERAVNVLRLNLALDRL"
FT   CDS             complement(122639..124168)
FT                   /transl_table=11
FT                   /gene="trcS"
FT                   /locus_tag="Rv1032c"
FT                   /product="TWO COMPONENT SENSOR HISTIDINE KINASE TRCS"
FT                   /function="SENSOR PART OF THE TWO COMPONENT REGULATORY
FT                   SYSTEM TRCS/TRCR."
FT                   /EC_number="2.7.3.-"
FT                   /note="Rv1032c, (MTCY10G2.17), len: 509 aa. trcS, two
FT                   component sensor histidine kinase protein (EC 2.7.3.-) (see
FT                   citations below), similar to YV16_MYCLE|P54883 probable
FT                   sensor-like histidine kinase from Mycobacterium leprae (443
FT                   aa), FASTA scores: opt: 392, E(): 3.8e-18, (31.7% identity
FT                   in 334 aa overlap). Note that in vitro autophosphorylation
FT                   of TrcS requires the presence of Mn2+or Ca2+as a divalent
FT                   cation cofactor and subsequent transphosphorylation of TrcR
FT                   is evident in the presence of TrcS-phosphate and Ca2+."
FT                   /db_xref="GOA:P96368"
FT                   /db_xref="HSSP:1BXD"
FT                   /db_xref="InterPro:IPR005467"
FT                   /db_xref="UniProtKB/TrEMBL:P96368"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06847.1"
FT                   /translation="MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVL
FT                   SLSGYVTAMNDAELVESLHALNHSYTRYRDSAQTSTPTGNLPMSQAVLEFTGQTPGNLI
FT                   AVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAAG
FT                   ADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAE
FT                   VATMPLTDDDHQISVRVRPGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQF
FT                   ITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSR
FT                   LSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNL
FT                   LTNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKS
FT                   RSNGSGHGLGLAIVSSIVKAHRGSVTAESGNGQTVFRVRLPMIEQQIATTA"
FT   CDS             complement(124176..124949)
FT                   /transl_table=11
FT                   /gene="trcR"
FT                   /locus_tag="Rv1033c"
FT                   /product="TWO COMPONENT TRANSCRIPTIONAL REGULATOR TRCR"
FT                   /function="SENSOR PART OF THE TWO COMPONENT REGULATORY
FT                   SYSTEM TRCS/TRCR. INVOLVED IN TRANSCRIPTIONAL
FT                   AUTOACTIVATION: TRCR ACTIVATES ITS OWN EXPRESSION BY
FT                   INTERACTING WITH THE AT-RICH SEQUENCE OF THE TRCR
FT                   PROMOTER."
FT                   /note="Rv1033c, (MTCY10G2.16), len: 257 aa. trcR,
FT                   two-component regulatory protein (see citations below),
FT                   similar to Q50825 TWO COMPONENT RESPONSE REGULATOR from
FT                   Mycobacterium tuberculosis (234 aa), FASTA scores: opt:
FT                   628, E(): 0, (46.0% identity in 226 aa overlap). Note that
FT                   in vitro autophosphorylation of TrcS requires the presence
FT                   of Mn2+or Ca2+as a divalent cation cofactor and subsequent
FT                   transphosphorylation of TrcR is evident in the presence of
FT                   TrcS-phosphate and Ca2+."
FT                   /db_xref="GOA:Q50806"
FT                   /db_xref="HSSP:1KGS"
FT                   /db_xref="InterPro:IPR011991"
FT                   /db_xref="UniProtKB/TrEMBL:Q50806"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06846.1"
FT                   /translation="MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTN
FT                   LVKMALHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRESDVYT
FT                   PTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRRSSHLERPADEALRV
FT                   GDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNPRRALSRTEILDRVWNYDFAGRTS
FT                   IVDLYISYLRKKIDSDREPMIHTVRGIGYMLRPPE"
FT   CDS             complement(125131..125520)
FT                   /transl_table=11
FT                   /locus_tag="Rv1034c"
FT                   /product="PROBABLE TRANSPOSASE (FRAGMENT)"
FT                   /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE
FT                   INSERTION ELEMENT IS1560."
FT                   /note="Rv1034c, (MTCY10G2.15), len: 129 aa. Probable IS1560
FT                   transposase fragment, similar to part of
FT                   Rv3387|E1202305|MTV004.45 (225 aa) (65.1% identity in 129
FT                   aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:P96367"
FT                   /protein_id="CAB06845.1"
FT                   /translation="MQQGNPPDAPQLAPAVAWVKKRAGRTPRTVTADRGYGEAAVDQQL
FT                   TEVGVKNVLIPRKGKPSQDRRAEEHRKAFRRTIKWRTGCEGRISHLKRGYGWDRGRIGG
FT                   LEGTRTWVGHGVFAHNLVTISALPA"
FT   repeat_region   complement(125134..126646)
FT                   /mobile_element="insertion sequence:IS1560-1"
FT                   /note="IS1560-1, len: 1513 bp. Insertion sequence IS1560."
FT   CDS             complement(125588..126274)
FT                   /transl_table=11
FT                   /locus_tag="Rv1035c"
FT                   /product="PROBABLE TRANSPOSASE (FRAGMENT)"
FT                   /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE
FT                   INSERTION ELEMENT IS1560."
FT                   /note="Rv1035c, (MTCY10G2.14), len: 228 aa. Probable IS1560
FT                   transposase fragment, similar to parts of
FT                   Rv3387|E1202305|MTV004.45 (225 aa) (47.8% identity in 67 aa
FT                   overlap) and Rv3386|E1202304|MTV004.44 (234 aa) (55.1%
FT                   identity in 127 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:P96366"
FT                   /protein_id="CAB06844.1"
FT                   /translation="MPHPTTLMKLTTRCGSAAIDGLNEALLAKAAEAKLLGTNRIRADT
FT                   TVARANVSYPTDLGLLAKAMRRIAATGKRIQAAGGAVRTRVGDRSRAAGRRAHAVAAKL
FT                   RSRAELGRDEARAAVLRFTGELAELAQAAAQEAQQLLDNAKQAVLRAKAKAAALAARGE
FT                   RDAVAGRRCGGLVRAVNDLTELLNATRQIVAQTRQRVAGITSDGASRRVSLHDGDARPD
FT                   HQGSAR"
FT   CDS             complement(126308..126646)
FT                   /transl_table=11
FT                   /locus_tag="Rv1036c"
FT                   /product="PROBABLE IS1560 TRANSPOSASE (FRAGMENT)"
FT                   /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE
FT                   INSERTION ELEMENT IS1560."
FT                   /note="Rv1036c, (MTCY10G2.13), len: 112 aa. Probable IS1560
FT                   transposase fragment, similar to part of
FT                   Rv3386|E1202304|MTV004.44 (234 aa) (82.8% identity in 87 aa
FT                   overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:P96365"
FT                   /protein_id="CAB06843.1"
FT                   /translation="MIPGRMVLNWEDGLNALVAEGIEAIVFRTLGDQCWLWESLLPDEV
FT                   RRLPEELARVDALLDDPAFFAPFVPFFDPRRGRPSTPMEVYLQLMFVKFRYRLGYESLC
FT                   REVADSIT"
FT   CDS             complement(126757..127041)
FT                   /transl_table=11
FT                   /gene="esxI"
FT                   /locus_tag="Rv1037c"
FT                   /standard_name="ES6_1, Mtb9.9D"
FT                   /product="PUTATIVE ESAT-6 LIKE PROTEIN ESXI (ESAT-6 LIKE
FT                   PROTEIN 1)"
FT                   /function="UNKNOWN"
FT                   /note="Rv1037c, (MTCY10G2.12), len: 94 aa. esxI, ESAT-6
FT                   like protein (see citations below), highly similar to
FT                   Q49946|ES6X_MYCLE|U1756D PUTATIVE ESAT-6 LIKE PROTEIN X
FT                   from Mycobacterium leprae (95 aa), FASTA scores: opt: 409,
FT                   E(): 6.3e-23, (64.15% identity in 92 aa overlap); Rv3619c,
FT                   Rv1198, Rv2346c, etc from Mycobacterium tuberculosis.
FT                   Strictly identical to
FT                   P96364|ES61_MYCTU|Rv3619c|MTCY15C10.33|MTCY07H7B.03|MT372 1
FT                   PUTATIVE ESAT-6 LIKE PROTEIN 1 (94 aa). BELONGS TO THE
FT                   ESAT6 FAMILY."
FT                   /db_xref="InterPro:IPR009416"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96364"
FT                   /protein_id="CAB06842.1"
FT                   /translation="MTINYQFGDVDAHGAMIRAQAGSLEAEHQAIISDVLTASDFWGGA
FT                   GSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA"
FT   CDS             complement(127068..127364)
FT                   /transl_table=11
FT                   /gene="esxJ"
FT                   /locus_tag="Rv1038c"
FT                   /standard_name="ES6_2, TB11.0, QILSS"
FT                   /product="ESAT-6 LIKE PROTEIN ESXJ (ESAT-6 LIKE PROTEIN 2)"
FT                   /function="UNKNOWN"
FT                   /note="Rv1038c, (MT1067, MTCY10G2.11), len: 98 aa. esxJ,
FT                   ESAT-6 like protein (see Gey Van Pittius et al., 2001),
FT                   similar to Q49945|U1756C, Mycobacterium leprae (100 aa),
FT                   FASTA scores: opt: 375, E(): 7.7e-21, (58.3% identity in 96
FT                   aa overlap). Member of M. tuberculosis hypothetical QILSS
FT                   protein family with Rv1197, Rv1792, Rv2347c and Rv3620c.
FT                   BELONGS TO THE ESAT6 FAMILY."
FT                   /db_xref="InterPro:IPR010310"
FT                   /db_xref="UniProtKB/Swiss-Prot:P96363"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06841.1"
FT                   /translation="MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGW
FT                   SGMAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS"
FT   CDS             complement(127510..128685)
FT                   /transl_table=11
FT                   /gene="PPE15"
FT                   /locus_tag="Rv1039c"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1039c, (MTCY10G2.10), len: 391 aa. Member of the
FT                   Mycobacterium tuberculosis PPE family of glycine-rich
FT                   proteins, most similar to Rv2768c|AL008967|MTV002_33
FT                   Mycobacterium tuberculosis H37Rv (394 aa), FASTA scores:
FT                   opt: 1721, E(): 0, (70.4% identity in 398 aa overlap)."
FT                   /db_xref="InterPro:IPR000030"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q7D8Y7"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55349.1"
FT                   /translation="MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAELGTTAASY
FT                   ESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAGSQAMASAAAYEAAYAMT
FT                   VPPEVVAANRALLAALVATNVLGINTPAIMATEALYAEMWAQDALAMYGYAAASGAAGM
FT                   LQPLSPPSQTTNPGGLAAQSAAVGSAAATAAVNQVSVADLISSLPNAVSGLASPVTSVL
FT                   DSTGLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAIPTAIFLANALNSGAPVAIA
FT                   EGAIEAAEGAASAAAAGLADSVTPAGLGASLGEATLVGRLSVPAAWSTAAPATTAGATA
FT                   LEGSGWTVAAEEAGPVTGMMPGMASAAKGTGAYAGPRYGFKPTVMPKQVVV"
FT   CDS             complement(128762..129589)
FT                   /transl_table=11
FT                   /gene="PE8"
FT                   /locus_tag="Rv1040c"
FT                   /product="PE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1040c, (MTCY10G2.09), len: 275 aa. Member of the
FT                   Mycobacterium tuberculosis PE family (see citation below),
FT                   most similar to AL008967|MTV002_34 Mycobacterium
FT                   tuberculosis H37Rv (275 aa), FASTA scores: opt: 1111, E():
FT                   0, (68.6% identity in 283 aa overlap)."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D8Y6"
FT                   /protein_id="CAE55350.1"
FT                   /translation="MSFLKTVPEELTAAAAQLGTIGAAMAAQNAAAAAPTTAIAPAALD
FT                   EVSALQAALFTAYGTFYQQVSAEAQAMHDMFVNTLGISAGTYGVTESLNSSAAASPLSG
FT                   ITGEASAIIQATTGLFPPELSGGIGNILNIGAGNWASATSTLIGLAGGGLLPAEEAAEA
FT                   ASALGGEAALGELGALGAAEAALGEAGIAAGLGSASAIGMLSVPPAWAGQATLVSTTST
FT                   LPGAGWTAAAPQAAAGTFIPGMPGVASAARNSAGFGAPRYGVKPIVMPKPATV"
FT   CDS             complement(130785..131648)
FT                   /transl_table=11
FT                   /locus_tag="Rv1041c"
FT                   /product="PROBABLE IS LIKE-2 TRANSPOSASE"
FT                   /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF AN
FT                   INSERTION ELEMENT."
FT                   /note="Rv1041c, (MTCY10G2.08), len: 287 aa. Probable IS
FT                   like-2 transposase, overlaps MTCY10G2.07. Similar to
FT                   Q00430|X53945 insertion element IS869 hypothetical protein
FT                   from Agrobacterium tumefaciens (186 aa), FASTA scores: opt:
FT                   173, E(): 0.00016, (40.9% identity in 176 aa overlap).
FT                   Similar to Rv1150, C-terminal part of transposase of
FT                   putative Mycobacterium tuberculosis IS like-1. MTCY10G2.07
FT                   and MTCY10G2.08 are frameshifted with respect to
FT                   Mycobacterium tuberculosis Q50761 transposase, the 10G2
FT                   cosmid sequence appears to be correct."
FT                   /db_xref="GOA:P96360"
FT                   /db_xref="InterPro:IPR002559"
FT                   /db_xref="UniProtKB/TrEMBL:P96360"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06871.1"
FT                   /translation="MRASPADGLAITGLSWKGSRGGSVREVRGGTCPLSSGRGKRCGSA
FT                   ITVGRWMVPATRCSPTLPRCSGWTLRWPRISRSCCRWIPRTCGHTSIRRAPARTRSPQG
FT                   ALSDYKKSADEPDDHAIGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLPLLD
FT                   DYRHASTEYALGSTDFRLLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAKGSAG
FT                   GRPPAFDAALYGLRNTVERGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHARVGTP
FT                   KLGDTP"
FT   repeat_region   130785..130802
FT                   /note="18 bp inverted repeat at the left end of IS-LIKE
FT                   element, CTAGGGCGTGTCTCCCAA"
FT   repeat_region   complement(130785..131762)
FT                   /mobile_element="insertion sequence:IS-LIKE-1"
FT                   /note="IS-LIKE-1, len: 978 bp. Insertion sequence, ISLIKE,
FT                   region identical to cosmid y348, blast score= 4902 (+1)
FT                   9377 10354 EM_NEW:MTAD20 Ad000020 Mycobacterium
FT                   tuberculosis sequence from clone y348"
FT   CDS             complement(131305..131712)
FT                   /transl_table=11
FT                   /locus_tag="Rv1042c"
FT                   /product="PROBABLE IS LIKE-2 TRANSPOSASE"
FT                   /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF AN
FT                   INSERTION ELEMENT."
FT                   /note="Rv1042c, (MTCY10G2.07), len: 135 aa. Probable IS
FT                   like-2 transposase, similar to Q50761 TRANSPOSASE from
FT                   Mycobacterium tuberculosis (308 aa), FASTA scores: opt:
FT                   823, E(): 0, (99.1% identity in 117 aa overlap). Second
FT                   copy is Rv1149."
FT                   /db_xref="UniProtKB/TrEMBL:P96359"
FT                   /protein_id="CAB06870.1"
FT                   /translation="MTRVGVISDEFWAVVEPLMPSHEGKPGRRFSDHRLILEGIAWRFR
FT                   TGSPWRDLPAEFGPWQTVWKRHHRWSLDGTCDEVFAHVAAVFGVDAEVAEDIEKLLSVD
FT                   STNVRAHQHSAGACSDTLATGGTVGLQEIRR"
FT   repeat_region   complement(131745..131762)
FT                   /note="18 bp inverted repeat at the right end of a IS-LIKE
FT                   element, CTAGGGCGTGTCTCCCAA"
FT   CDS             complement(131994..133019)
FT                   /transl_table=11
FT                   /locus_tag="Rv1043c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1043c, (MTCY10G2.06), len: 341 aa. Conserved
FT                   hypothetical protein similar to AL096872|SC5F7.08 PUTATIVE
FT                   LIPOATE-PROTEIN LIGASE from Streptomyces coelicolor (362
FT                   aa), FASTA scores: opt: 206, E(): 1.4e-05, (30.3% identity
FT                   in 201 aa overlap). Weak similarity to P39668|YYXA_BACSU
FT                   HYPOTHETICAL PROTEASE from Bacillus subtitis (400 aa),
FT                   FASTA scores: opt: 159, E(): 0.013, (27.1% identity in 210
FT                   aa overlap)."
FT                   /db_xref="GOA:P96358"
FT                   /db_xref="UniProtKB/TrEMBL:P96358"
FT                   /protein_id="CAB06869.1"
FT                   /translation="MCAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSVA
FT                   DFSRYLSTLGLPAAGDAVTLHRILSSMERAGLLLPLGWDPRLPVMGQKYISQGAISKGQ
FT                   RGGNLWLSEVFGAELIIPSYNAVTVQLAGHDDAGNPVDSWGTGLVVDHNHVITNKHVVT
FT                   GLAGTSAGLSVYPSSNHAEAELVNFSGTAHPHPTLDVAVIKFEMPEGKYIPRLGGMAFR
FT                   DPDWADEVYVFGYPRVPMTAEMAITVQRGEVVNPAATTIPGRQKIFLYSAIARPGNSGG
FT                   PIVAQDGRVIGLVVEDSAEAPSTGTGPNAAPFYRGIPSSEVIRALDELDFGGIVEMDTL
FT                   P"
FT   CDS             133266..133889
FT                   /transl_table=11
FT                   /locus_tag="Rv1044"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1044, (MTCY10G2.05c), len: 207 aa. Conserved
FT                   hypothetical protein, similar to Mycobacterium tuberculosis
FT                   hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta
FT                   scores: E(): 8.9e-06, (30.7% identity in 150 aa overlap).
FT                   Some similarity to U36837|LLU36837_1 Lactococcus lactis
FT                   plasmid pNP40 (287 aa), FASTA scores: opt: 147, E ():
FT                   0.0087, (29.7% identity in 91 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:P96357"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06868.1"
FT                   /translation="MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQ
FT                   LRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAVSWTLGRGVISHESALALHALADVN
FT                   PSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTGTDP
FT                   YQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA"
FT   CDS             133886..134767
FT                   /transl_table=11
FT                   /locus_tag="Rv1045"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1045, (MTCY10G2.04c), len: 293 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="InterPro:IPR014942"
FT                   /db_xref="UniProtKB/TrEMBL:P96356"
FT                   /protein_id="CAB06867.1"
FT                   /translation="MTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQF
FT                   AATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKDFDTVARRDIELIHEQLADAGETGW
FT                   EGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDTLTS
FT                   DALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDA
FT                   DLMPTRSACIAIFEARAQHPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQ
FT                   RFVARIDRATKR"
FT   CDS             complement(134917..135441)
FT                   /transl_table=11
FT                   /locus_tag="Rv1046c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1046c, (MTCY10G2.03), len: 174 aa. Hypothetical
FT                   unknown protein. Start changed since first submission (-65
FT                   aa)."
FT                   /db_xref="UniProtKB/TrEMBL:O86321"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06874.2"
FT                   /translation="MKVQARVGWNRRQLSAVGGRGQQLFANAPGHIPSTSHRRGTGDIN
FT                   RKIDESLAGAARPQANANYGATSDPPLTHQPKPGSPTQVGPRSPSPPGLRGLVKQLPEV
FT                   HQSSLHLDTVASLPSSRPSPHHTPLALRSRSGHFSPDEIRNRRSRKRSQSHMPPRTPPR
FT                   GRCLRAPEALA"
FT   repeat_region   135511..136945
FT                   /mobile_element="insertion sequence:IS1081-1"
FT                   /note="IS1081-1, len: 1435 bp. Insertion sequence IS1081,
FT                   almost identical to Mycobacterium bovis IS1081 (7157 (-1)
FT                   60 14 94 EM_BA:MBBIS1081 X84741 Mycobacterium bovis BCG
FT                   IS1081 DNA. 4/96"
FT   CDS             135636..136883
FT                   /transl_table=11
FT                   /locus_tag="Rv1047"
FT                   /product="PROBABLE TRANSPOSASE"
FT                   /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE
FT                   INSERTION ELEMENT IS1081."
FT                   /note="Rv1047, (MTCY10G2.02c), len: 415 aa. IS1081
FT                   transposase, most similar to TRA1_MYCBO|P35882 transposase
FT                   for insertion sequence element (415 aa), FASTA scores: opt:
FT                   2675, E(): 0, (99.8% identity in 415 aa overlap). Contains
FT                   PS01007 Transposases, Mutator family, signature"
FT                   /db_xref="GOA:P96354"
FT                   /db_xref="InterPro:IPR001207"
FT                   /db_xref="UniProtKB/TrEMBL:P96354"
FT                   /protein_id="CAB06866.1"
FT                   /translation="MTSSHLIDAEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALC
FT                   GAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALT
FT                   SVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTF
FT                   LAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVAR
FT                   GLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSI
FT                   YDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIWSNNPQE
FT                   RLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTST
FT                   EEPAKQQTTNTPALTT"
FT   misc_feature    136332..136406
FT                   /note="PS01007 Transposases, Mutator family, signature"
FT   CDS             complement(137251..138366)
FT                   /transl_table=11
FT                   /locus_tag="Rv1048c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1048c, (MTV017.01c-MTCY10G2.01), len: 371 aa.
FT                   Hypothetical unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:P96353"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB06875.1"
FT                   /translation="MQASDRTWQSNFIRRWYFTETVEYRPLVKYDASMSWDERTVSALE
FT                   GAFRSEVRARRVNGPHRDVIVSLDGAEFLVRWLTTGWPRQVAEALHATSRPDILAAPTM
FT                   SPGARKAAHDAGVGWVDESGAADIHYRNTSTGTTLVIETKGAPPAPLDARIGWRRATLA
FT                   VCEALLANIAGPTVASVVEATGLSMGSSAQALKFLEKNGHLASATARGPKSARLIVDRD
FT                   ALLDAYAEAADKLRSPISISTGVLWRDPTAGVVKAGQLWDAAGIEWAATSALSASLLAP
FT                   MQTEIAPMEIYVPGRSWSDLRRAAMAAGLQEIAGGRLILRFFPTPACARLTEQNLQGFR
FT                   SMLWPRVYADLRTAGVRGEDAAEHLREAMTK"
FT   CDS             138599..139045
FT                   /transl_table=11
FT                   /locus_tag="Rv1049"
FT                   /product="PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT                   /note="Rv1049, (MTV017.02), len: 148 aa. Probable
FT                   transcriptional repressor protein, similar to many e.g.
FT                   P74870 NEGATIVE REGULATOR OF EMR LOCUS EMR from Salmonella
FT                   typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,
FT                   (31.6% identity in 95 aa overlap). TBparse score is 0.892.
FT                   Contains probable helix-turn -helix motif at aa 58-79
FT                   (Score 1495, +4.28 SD)."
FT                   /db_xref="GOA:O53397"
FT                   /db_xref="HSSP:1B1B"
FT                   /db_xref="InterPro:IPR000835"
FT                   /db_xref="UniProtKB/TrEMBL:O53397"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17165.1"
FT                   /translation="MGKGAAFDECACYTTRRAARQLGQAYDRALRPSGLTNTQFSTLAV
FT                   ISLSEGSAGIDLTMSELAARIGVERTTLTRNLEVMRRDGLVRVMAGADARCKRIELTAK
FT                   GRAALQKAVPLWRGVQAEVTASVGDWPRVRRDIANLGQAAEACR"
FT   CDS             139094..139999
FT                   /transl_table=11
FT                   /locus_tag="Rv1050"
FT                   /product="PROBABLE OXIDOREDUCTASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM"
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv1050, (MTV017.03), len: 301 aa. Probable
FT                   oxidoreductase (EC 1.-.-.-) similar to many e.g.
FT                   Rv1543|MTCY48.22C|Q10783 PUTATIVE OXIDOREDUCTASE CY48.22C
FT                   (341 aa), FASTA scores: opt: 462, E(): 3e-22, (33.6%
FT                   identity in 265 aa overlap). TBparse score is 0.896."
FT                   /db_xref="GOA:O53398"
FT                   /db_xref="HSSP:1GZ6"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O53398"
FT                   /protein_id="CAA17166.1"
FT                   /translation="MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGAL
FT                   RRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGPVDAE
FT                   TFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRKAFARFAGYSSAMH
FT                   AIAGFSDALRQELRGSGIAVSVIHPALTQTPLLANVDPADMPPPFRSLTPIPVHWVAAA
FT                   VLDGVARRRARVVVPFQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQ
FT                   PTESAKAQAAQPERGYSSAR"
FT   CDS             complement(140158..140913)
FT                   /transl_table=11
FT                   /locus_tag="Rv1051c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1051c, (MTV017.04c), len: 251 aa. Conserved
FT                   hypothetical protein, similar to LLU36837|U36837.1 protein
FT                   encoded by Lactococcus lactis plasmid pNP40 (298 aa), FASTA
FT                   scores: opt: 194, E(): 3.5e-06, (30.3% identity in 155 aa
FT                   overlap). TBparse score is 0.912. Contains possible
FT                   helix-turn-helix motif at aa 197-218 (Score 1097, +2.92
FT                   SD)."
FT                   /db_xref="GOA:O53399"
FT                   /db_xref="InterPro:IPR014942"
FT                   /db_xref="UniProtKB/TrEMBL:O53399"
FT                   /protein_id="CAA17167.1"
FT                   /translation="MRADVTAEHLTQVVRDIAVIDIDDGVAFNLDTSSVQEIRERADYP
FT                   GLRVRVAMSVGPWQGIAAWDVSTGEPIAPWPTRVTIDRILGEPITLLGYAPETIIAEKG
FT                   VTILERGITSTRWRDYVDIVQLDRRGIDDDELLRSARAVAQYRGATLEPVAPHLAGYGA
FT                   VAQAKWATEHGRCQHCWRHWKPAHVGRRNMDLLDAKQVSEMIGVPVGTLRHWRHSDIGP
FT                   ASFTLGRRVVYRRDEVSRWISKRESATRR"
FT   CDS             141936..142325
FT                   /transl_table=11
FT                   /locus_tag="Rv1052"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1052, (MTV017.05), len: 129 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O53400"
FT                   /protein_id="CAA17168.1"
FT                   /translation="MDCCEERGVARHKGLSQVGTPGCPRWSQAVSCRCSAYREAAVTAV
FT                   QMPLTPGYGETPLPHDELAALLPEVVEVLDKPITRADVYDLEQGLQDQVFDLLMPTAVE
FT                   GSLSLDELLSDHFVRDLHARMFGPV"
FT   CDS             complement(142224..142499)
FT                   /transl_table=11
FT                   /locus_tag="Rv1053c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1053c, (MTV017.06c), len: 91 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O53401"
FT                   /protein_id="CAA17169.1"
FT                   /translation="MDSHKVCMNNNTQLPTGPIIGVHPAVRDGVERVAYLDGDLLRCNT
FT                   DVEFTSSPPPGPVLYRTKHTRVEIADEMVTEKLIKRQRAFNSRRHQ"
FT   CDS             143141..143455
FT                   /transl_table=11
FT                   /locus_tag="Rv1054"
FT                   /product="PROBABLE INTEGRASE (FRAGMENT)"
FT                   /function="USE FOR SEQUENCE INTEGRATION. INTEGRASE IS
FT                   NECESSARY FOR INTEGRATION OF A PHAGE INTO THE HOST GENOME
FT                   BY SITE-SPECIFIC RECOMBINATION. IN CONJUNCTION WITH
FT                   EXCISIONASE, INTEGRASE IS ALSO NECESSARY FOR EXCISION OF
FT                   THE PROPHAGE FROM THE HOST GENOME (BY SIMILARITY)."
FT                   /note="Rv1054, (MTV017.07), len: 104 aa. Probable integrase
FT                   (fragment), similar to Rv2309c|MTCY3G12_25|Z79702
FT                   hypothetical protein (shows similarity to integrases) from
FT                   Mycobacterium tuberculosis (151 aa), FASTA scores: opt:
FT                   273, E(): 8.8e-13, (64.7% identity in 68 aa overlap); and
FT                   to L39071|MSGINT_1 integrase from Mycobacterium
FT                   paratuberculosis (191 aa), FASTA scores: opt: 105, E():
FT                   0.9, (31.8% identity in 85 aaoverlap). This ORF continues
FT                   in another frame as Rv1055|MTV017.08 but no error can be
FT                   found to account for frameshift. Length extended since
FT                   first submission (+36 aa)."
FT                   /db_xref="InterPro:IPR014417"
FT                   /db_xref="UniProtKB/TrEMBL:O53402"
FT                   /protein_id="CAA17170.2"
FT                   /translation="MTGKGIVESTTKTKRDRHVPVPEPVWRRLHAELPTDPNALVFPGR
FT                   KGGFLPLGEYRWAFDNAGDQVGIEGWYRTVWGTPRPRWRSAQALTSRSCNGSLDTQQRR
FT                   "
FT   CDS             143452..143586
FT                   /transl_table=11
FT                   /locus_tag="Rv1055"
FT                   /product="POSSIBLE INTEGRASE (FRAGMENT)"
FT                   /function="USE FOR SEQUENCE INTEGRATION. INTEGRASE IS
FT                   NECESSARY FOR INTEGRATION OF A PHAGE INTO THE HOST GENOME
FT                   BY SITE-SPECIFIC RECOMBINATION. IN CONJUNCTION WITH
FT                   EXCISIONASE, INTEGRASE IS ALSO NECESSARY FOR EXCISION OF
FT                   THE PROPHAGE FROM THE HOST GENOME (BY SIMILARITY)."
FT                   /note="Rv1055, (MTV017.08), len: 44 aa. Possible integrase
FT                   (fragment); first 49 aa similar to
FT                   Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows
FT                   similarity to integrases) from Mycobacterium tuberculosis
FT                   (151 aa), FASTA scores: opt: 291, E(): 2.2e-16, (74.3%
FT                   identity in 70 aa overlap); and to L39071|MSGINT_1
FT                   integrase from Mycobacterium paratuberculosis (191 aa),
FT                   FASTA scores: opt: 146, E(): 8.3e-05, (52.1% identity in 48
FT                   aa overlap); and to many other integrases or transposases.
FT                   Shortened since first submission (-34 aa)."
FT                   /db_xref="UniProtKB/TrEMBL:O53403"
FT                   /protein_id="CAA17171.2"
FT                   /translation="MTLDRHGHLLNDDLAVWPMRCAKSSRTLRYHCGMRRRNRVGLRA"
FT   tRNA            143609..143682
FT                   /gene="tRNA-Leu(TAA)"
FT                   /product="transfer RNA-Leu(TAA)"
FT                   /anticodon=(pos:143643..143645,aa:Leu)
FT   CDS             143841..144605
FT                   /transl_table=11
FT                   /locus_tag="Rv1056"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1056, (MTV017.09), len: 254 aa. Conserved
FT                   hypothetical protein, some similarity in C-terminal region
FT                   of Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126
FT                   aa), FASTA scores: opt: 254, E(): 1.2e-10, (43.4% identity
FT                   in 106 aa overlap); and to Rv1670. C-terminal region is
FT                   similar to AL035569|SC8D9.02 hypothetical protein from
FT                   Streptomyces coelicolor (113 aa), FASTA scores: opt: 282,
FT                   E(): 4.5e-12, (48.0% identity in 100 aa overlap). TBparse
FT                   score is 0.925."
FT                   /db_xref="InterPro:IPR007361"
FT                   /db_xref="UniProtKB/TrEMBL:O53404"
FT                   /protein_id="CAA17172.1"
FT                   /translation="MSVDYPQMAATRGRIEPAPRRVRGYLGHVLVFDTSAARYVWEVPY
FT                   YPQYYIPLADVRMEFLRDENHPQRVQLGPSRLHSLVSAGQTHRSAARVFDVDGDSPVAG
FT                   TVRFNWDPLRWFEEDEPIYGHPRNPYQRADALRSHRHVRVELDGIVLADTRSPVLLFET
FT                   GIPTRYYIDPADIAFEHLEPTSTQTLCPYKGTTSGYWSVRVGDAVHRDLAWTYHYPLPA
FT                   VAPIAGLVAFYNEKVDLTVDGVALPRPHTQFS"
FT   repeat_region   145558..145608
FT                   /note="51 bp Mycobacterial Interspersed Repetitive Unit,
FT                   Class II"
FT   CDS             145609..146790
FT                   /transl_table=11
FT                   /locus_tag="Rv1057"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1057, (MTV017.10), len: 393 aa. Conserved
FT                   hypothetical protein, some similarity to X84710|MMSAG_1
FT                   surface antigen of Methanosarcina mazeii (491 aa), FASTA
FT                   scores: opt: 363, E():6.2e-15, (31.3% identity in 294 aa
FT                   overlap). TBparse score is 0.892."
FT                   /db_xref="InterPro:IPR015943"
FT                   /db_xref="UniProtKB/TrEMBL:O53405"
FT                   /protein_id="CAA17173.1"
FT                   /translation="MSVMNGREVARESRDAQVFEFGTAPGSAVVKIPVQGGPIGGIAIS
FT                   RDGSLLVVTNNGTDTVSVVGTDTCRVTQTVTSVNEPFAIAMGNAEANRAYVSTVSSAYD
FT                   AIAVIDVATNTVLGTHPLALSVSDLTLSPDDKYLYVSRNGTRGADVAVLDTTTGALIDV
FT                   VDVSQAPGTTTQCVRMSPDGSVLYVGANGPSGGLLVVITTRAQSDGGRIGSRSRSRQKS
FT                   SKPRGNQAAAGLRVVATIDIGSSVRDVALSPDGAIAYVASCGSDFGAVVDVIDTRTHQI
FT                   TSSRAISEIGGLVTRVSVSGDADRAYLVSEDRVTVLCTRTHDVIGTIRTGQPSCVVESP
FT                   DGKYLYIADYSGTITRTAVASTIVSGTEQLALQRRGSMQWFSPELQQYAPALA"
FT   CDS             146897..148528
FT                   /transl_table=11
FT                   /gene="fadD14"
FT                   /locus_tag="Rv1058"
FT                   /product="PROBABLE MEDIUM CHAIN FATTY-ACID-CoA LIGASE
FT                   FADD14 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-COA
FT                   SYNTHASE)"
FT                   /function="INVOLVED IN THE FATTY ACID BETA OXIDATION
FT                   PATHWAY (DEGRADATION)."
FT                   /EC_number="6.2.1.-"
FT                   /note="Rv1058, (MTV017.11), len: 543 aa. Probable fadD14,
FT                   medium-chain fatty-acid-CoA synthetase (EC 6.2.1.-), highly
FT                   similar to many e.g. CAC32346.1|AL583945 putative fatty
FT                   acid CoA ligase from Streptomyces coelicolor (558 aa);
FT                   N-terminus of NP_419738.1|NC_002696
FT                   medium-chain-fatty-acid--CoA ligase from Caulobacter
FT                   crescentus (1006 aa); Q00594|ALKK_PSEOL
FT                   MEDIUM-CHAIN-FATTY-ACID--CoA LIGASE (EC 6.2.1.-) from
FT                   Pseudomonas oleovorans (546 aa), FASTA scores: opt: 1468,
FT                   E(): 0, (41.1% identity in 538 aa overlap); etc. Contains
FT                   PS00455 Putative AMP-binding domain signature. BELONGS TO
FT                   THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. TBparse score
FT                   is 0.916."
FT                   /db_xref="GOA:O53406"
FT                   /db_xref="HSSP:1BA3"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="UniProtKB/TrEMBL:O53406"
FT                   /protein_id="CAA17174.1"
FT                   /translation="MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEGYRHSSYRDVG
FT                   QRAGQLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAY
FT                   VTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAVGEGDTTPLREAGKTVLRFAELID
FT                   AESPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGIGVGSSDK
FT                   VLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVPTIWND
FT                   VMHYLEKDPDHDMSSLRLVACGGSAVPESLMRTFEDKHDVQIRQLWGMTETSPLATMAW
FT                   PPPGTPDDQHWAFRITQGQPVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYG
FT                   GRDESKFDSGWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
FT                   EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERWAFVDEIPRT
FT                   SVGKYDKKAIRSRYAEGAYQITEVHT"
FT   misc_feature    147440..147475
FT                   /note="PS00455 Putative AMP-binding domain signature"
FT   CDS             148604..149668
FT                   /transl_table=11
FT                   /locus_tag="Rv1059"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1059, (MTV017.12), len: 354 aa. Conserved
FT                   hypothetical protein, similar to Rv0926c|MTCY21C12.20c
FT                   hypothetical protein from Mycobacterium tuberculosis (358
FT                   aa), FASTA scores: opt: 338, E(): 1.4e-14, (33.1% identity
FT                   in 363 aa overlap). TBparse score is 0.909."
FT                   /db_xref="GOA:O53407"
FT                   /db_xref="InterPro:IPR000846"
FT                   /db_xref="UniProtKB/TrEMBL:O53407"
FT                   /protein_id="CAA17175.1"
FT                   /translation="MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKD
FT                   VGEIIGSPPLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVVTPLGWFY
FT                   PSEKEAAPLEVAAQAGNATLHGAGIGPGAVTELFPLLLSVMSTGVTFVRSEEFSDLRSY
FT                   GAPDVLRYVMGFGGTPDSALTGPMQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAV
FT                   ATAPIDSPIGVIEPGQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGER
FT                   YEIEVRGSPDTCVTIKGWQPQTVAAGLKSNPGIVATAAHCVNAIPATCAAPAGIQSFFD
FT                   LPLITGRAAPGLAR"
FT   CDS             149721..150194
FT                   /transl_table=11
FT                   /locus_tag="Rv1060"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1060, (MTV017.13), len: 157 aa. Hypothetical
FT                   unknown protein. TBparse score is 0.912."
FT                   /db_xref="InterPro:IPR019587"
FT                   /db_xref="UniProtKB/TrEMBL:O53408"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17176.1"
FT                   /translation="MAKSVVVEQSRAIPVQSEDAFGGTLAAALPVICSHWYGLIPPIKE
FT                   VRDQTGAWDSVGQARVITMVGGGRVREELTSVDPPRSFGYTLTDIKGPLAPLVALVEGK
FT                   WSFAPADTGTTVTWQWTIHPRSALAAPVLPVFARMWRGYARGVLEKLSALLVG"
FT   CDS             150228..151091
FT                   /transl_table=11
FT                   /locus_tag="Rv1061"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1061, (MTV017.14), len: 287 aa. Conserved
FT                   hypothetical protein, similar to hypothetical proteins from
FT                   various bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp.
FT                   PCC6803 (304 aa),FASTA scores: opt: 245, E():1.2e-09,
FT                   (27.1% identity in 258 aa overlap). TBparse score is
FT                   0.923."
FT                   /db_xref="GOA:O53409"
FT                   /db_xref="InterPro:IPR017932"
FT                   /db_xref="UniProtKB/TrEMBL:O53409"
FT                   /protein_id="CAA17177.1"
FT                   /translation="MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRRNPDGTGLGVFDE
FT                   HHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGSLDIRNTHPFLQDGRIFA
FT                   HNGVVEGLDVLDERLREVGADDLVLGQTDSERVFALITASIRARDGNESAGLIDALRWL
FT                   AANVPIYAVNVLLSTATDVWALRYPESHELYILDRRGDGAPEFHLRSKRIRAHSTHLRE
FT                   RSSVVFATEPMDDNPRWRLLDAGELVHVDAALRVNRSLVLPDPPRHPIRREDLSEPVLH
FT                   AQHTSA"
FT   CDS             151096..151953
FT                   /transl_table=11
FT                   /locus_tag="Rv1062"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1062, (MTV017.15), len: 285 aa. Conserved
FT                   hypothetical protein, some similarity to AL079356|SC6G9_10
FT                   hypothetical protein in Streptomyces coelicolor (289 aa),
FT                   FASTA scores: opt: 556, E(): 1.2e-27, (39.0% identity in
FT                   287 aa overlap), and Z99111|BSUB0008_176 Bacillus subtilis
FT                   (260aa), FASTA scores: opt: 163, E(): 0.0013, (27.4%
FT                   identity in 179aa overlap). TBparse score is 0.902."
FT                   /db_xref="GOA:O53410"
FT                   /db_xref="InterPro:IPR002641"
FT                   /db_xref="UniProtKB/TrEMBL:O53410"
FT                   /protein_id="CAA17178.1"
FT                   /translation="MTTRRALVLAGGGLAGIAWETGVLRGIADESPAAARLLLDSDVLV
FT                   GTSAGATVAAQISSGCPLDTLYERQLAETSAEIDPGVDIDAITDLFLTAVTEPHISTRR
FT                   RLQRIGAVALAVDTVPESVRRQVIAQRLPSHDWPDRVLRVTAIDIATGELVVFHRESNV
FT                   ALVDAVAASCSVPGAWPPVTIAGRRYMDGGVASSVNLGVADDCDAAVVLVPAGADAPSP
FT                   FGGGAAAEIAAATGMVFAVFADDDSLAAFGPNPLDPLCRVNSAMAGRQQGRREAQAVAR
FT                   LLGV"
FT   CDS             complement(151954..153036)
FT                   /transl_table=11
FT                   /locus_tag="Rv1063c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1063c, (MTV017.16c), len: 360 aa. Conserved
FT                   hypothetical protein, similar to P37053|YCHK_ECOLI
FT                   hypothetical protein from Escherichia coli (314 aa), FASTA
FT                   scores: opt: 487, E(): 7.2e-23, (32.7% identity in 321 aa
FT                   overlap). Also partially similar to Rv3239c|MTCY20B11.14c.
FT                   TBparse score is 0.893. BELONGS TO THE UPF0028 (SWS)
FT                   FAMILY."
FT                   /db_xref="GOA:P67098"
FT                   /db_xref="InterPro:IPR002641"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67098"
FT                   /protein_id="CAA17179.1"
FT                   /translation="MPAPAALRVRGSSSPRVALALGSGGARGYAHIGVIQALRERGYDI
FT                   VGIAGSSMGAVVGGVHAAGRLDEFAHWAKSLTQRTILRLLDPSISAAGILRAEKILDAV
FT                   RDIVGPVAIEQLPIPYTAVATDLLAGKSVWFQRGPLDAAIRASIAIPGVIAPHEVDGRL
FT                   LADGGILDPLPMAPIAGVNADLTIAVSLNGSEAGPARDAEPNVTAEWLNRMVRSTSALF
FT                   DVSAARSLLDRPTARAVLSRFGAAAAESDSWSQAPEIEQRPAGPPADREEAADTPGLPK
FT                   MGSFEVMNRTIDIAQSALARHTLAGYPADLLIEVPRSTCRSLEFHRAVEVIAVGRALAT
FT                   QALEAFEIDDDESAAATIEG"
FT   CDS             complement(153117..153536)
FT                   /transl_table=11
FT                   /gene="lpqV"
FT                   /locus_tag="Rv1064c"
FT                   /product="POSSIBLE LIPOPROTEIN LPQV"
FT                   /function="UNKNOWN"
FT                   /note="Rv1064c, (MTV017.17c), len: 139 aa. Possible
FT                   lipoprotein LpqV. Has N-terminal signal sequence and
FT                   appropriately positioned PS00013 Prokaryotic membrane
FT                   lipoprotein lipid attachment site. TBparse score is 0.912."
FT                   /db_xref="GOA:P65310"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65310"
FT                   /protein_id="CAA17180.1"
FT                   /translation="MRPSRYAPLLCAMVLALAWLSAVAGCSRGGSSKAGRSSSVAGTLP
FT                   AGVVGVSPAGVTTRVDAPAESTEEEYYQACHAARLWMDAQPGSGESLIEPYLAVVQASP
FT                   SGVAGSWHIRWAALTPARQAAVIVAARAAANAECG"
FT   misc_feature    complement(153459..153491)
FT                   /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT                   attachment site"
FT   CDS             153648..154214
FT                   /transl_table=11
FT                   /locus_tag="Rv1065"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1065, (MTV017.18), len: 188 aa. Conserved
FT                   hypothetical protein, some similarity to AL0209|SC4H8_11
FT                   hypothetical protein from Streptomyces coelicolor (182 aa),
FT                   FASTA scores: opt: 156, E(): 0.0011, (31.3% identity in 195
FT                   aa overlap). TBparse score is 0.921."
FT                   /db_xref="GOA:O53413"
FT                   /db_xref="InterPro:IPR010300"
FT                   /db_xref="UniProtKB/TrEMBL:O53413"
FT                   /protein_id="CAA17181.1"
FT                   /translation="MVMPLVTPTTAVPSPGPTRLRVADLLRATDQAADDVLGGRCDHLL
FT                   PDGGVPQTQRWYTRIHGDEELDIWLISWVPGQPTELHDHGGSLGALTVLSGSLNEYRWD
FT                   GRRLRRRRLDAGDQAGFPLGWVHDVVWAPRPIGGPDAAGMAVAPTLSVHAYSPPLTAMS
FT                   YYEITERNTLRRQRTELTDQPEGSG"
FT   CDS             154211..154606
FT                   /transl_table=11
FT                   /locus_tag="Rv1066"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1066, (MTV017.19), len: 131 aa. Conserved
FT                   hypothetical protein, strong similarity to AL0209|SC4H8.10
FT                   hypothetical protein from Streptomyces coelicolor (132 aa),
FT                   FASTA scores: opt: 429, E(): 5.2e-23, (57.1% identity in
FT                   119 aa overlap). TBparse score is 0.859."
FT                   /db_xref="InterPro:IPR001763"
FT                   /db_xref="UniProtKB/TrEMBL:O53414"
FT                   /protein_id="CAA17182.1"
FT                   /translation="MSRIDRVLEAARRRYRRLAADQVPEAARRGAVLVDIRPQAQRARE
FT                   GEVPGALVIERNVLEWRCDPTSDARLPQAVDDDVEWVILCSEGYTSSLAAASLLDLGLH
FT                   RATDVVGGYRALAAGGVLAELGGAVGG"
FT   CDS             complement(154634..156637)
FT                   /transl_table=11
FT                   /gene="PE_PGRS19"
FT                   /locus_tag="Rv1067c"
FT                   /product="PE-PGRS FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1067c, (MTV017.20c), len: 667 aa. Member of the
FT                   Mycobacterium tuberculosis PE family, PGRS subfamily of
FT                   gly-rich proteins (see Brennan & Delogu 2002). Similar to
FT                   Rv3388|MTV004.46 M. tuberculosis (731 aa), FASTA scores:
FT                   opt: 2227, E(): 0, (55.6% identity in 710 aa overlap).
FT                   Contains PS00583 pfkB family of carbohydrate kinases
FT                   signature 1, probably fortuitous. TBparse score is 0.837."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FT3"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55351.1"
FT                   /translation="MSFVLVSPSQLMAAAADVAGIGSAISAANAAALAPTSVLAAAGAD
FT                   EVSAAVAALFSAHAGQYQQLGARAALFHEQFVQALTGAASAYASAEATNVEQQVLGLIN
FT                   APTQALLGRPLIGNGADGTAANPNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIGN
FT                   GGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPAGAIGAPGVAGGAGGAGGTAGLF
FT                   GNGGVGGVGGDGGQGGNGAGAGASGTKGGDAGAGGAGGAGGWIHGHGGAGGDGGAGGAG
FT                   GQASPGAPGPPSQPGGAGGAGGAGGRGGDGGSAGWLSGNGGDAGNGGGGGTAGGAGNGG
FT                   QFGGDGGTGGTGGTAGAGGNGGRGAVLFGHGGNAGHGGAGGNGAAAGAGGEHVVATAGK
FT                   GGTGGVGGDGGGGGAGGGGGLLYGNGGAGGAGNSGGDGGTGLNAALGGNGGGGGVGGNA
FT                   GAGGTGGSAGWLSGNGGAGGSGGSAGAGGAGGKGGDTPNGLAINPGIGGNGGDTGNAGN
FT                   GGNGGSAARLFGGGGAGGAGGTGSTAGSGGSGGTNPPTGLQAAGGNGGSGHAGGHGGNG
FT                   GGAGLLGGGGTGGNGGGGGQGGLGAAAGGVDGNGGNGGNGGKGGDAQLVGDGGNGGNGG
FT                   KGGAGLIAGLDGAGGAGGTRGLIFGNAGTPGQ"
FT   misc_feature    complement(155255..155329)
FT                   /note="PS00583 pfkB family of carbohydrate kinases
FT                   signature 1"
FT   CDS             complement(156970..158361)
FT                   /transl_table=11
FT                   /gene="PE_PGRS20"
FT                   /locus_tag="Rv1068c"
FT                   /product="PE-PGRS FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1068c, (MTV017.21c), len: 463 aa. Member of the
FT                   Mycobacterium tuberculosis PE family, PGRS subfamily of
FT                   gly-rich proteins (see Brennan & Delogu 2002). Similar to
FT                   AL021897|MTV017_19 Mycobacterium tuberculosis H37Rv (667
FT                   aa), FASTA scores: opt: 1875, E(): 0, (55.0% identity in
FT                   667 aa overlap). TBparse score is 0.849."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53416"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55352.1"
FT                   /translation="MSYMIAVPDMLSSAAGDLASIGSSINASTRAAAAATTRLLPAAAD
FT                   EVSAHIAALFSGHGEGYQAIARQMAAFHDQFTLALTSSAGAYASAEATNVEQQVLGLIN
FT                   APTQALLGRPLIGNGADGTAANPNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIGN
FT                   GGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPAGAIGAPGVAGGAGGAGGTAGLF
FT                   GNGGAGGAGGAGGAGGRGGDGGSAGWLSGNGGDAGTGGGGGNAGNGGNGGSAGWLSGNG
FT                   GTGGGGGTAGAGGQGGNGNSGIDPGNGGQGADTGNAGNGGHGGSAAKLFGDGGAGGAGG
FT                   MGSTGGTGGGGGFGGGTGGNGGNGHAGGAGGSGGTAGLLGSGGSGGTGGDGGNGGLGAG
FT                   SGAKGNGGNGGDGGKGGDAQLIGNGGNGGNGGKGGTGLMPGINGTGGAGGSRGQISGNP
FT                   GTPGQ"
FT   CDS             complement(158723..160486)
FT                   /transl_table=11
FT                   /locus_tag="Rv1069c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1069c, (MTV017.22c), len: 587 aa. Conserved
FT                   hypothetical protein, hydrophobic regions in N-terminal
FT                   domain. Similar in part to O07136|B1306.04C B1306.04c
FT                   protein from Mycobacterium leprae (89 aa), FASTA scores:
FT                   opt: 229, E(): 1.3e-07, (54.2% identity in 72 aa overlap).
FT                   TBparse score is 0.907."
FT                   /db_xref="InterPro:IPR012037"
FT                   /db_xref="UniProtKB/TrEMBL:O53417"
FT                   /protein_id="CAA17185.1"
FT                   /translation="MTEPAAATTTNASDEPATGAEQAVDTAATPQTPEPQPIRSTWWIR
FT                   HYTFTGTAMGLVFVWFSMTPSLLPRGPLFQGLVSGICGAFGYGLGVFAVWLVRYMRSHN
FT                   SSPPPPRWAWPPLIAVGAVGMVGMAVQFHVWQDDVRDLMGVEHLRWYDYPLAAALSLVV
FT                   LFTLVEIGQFIRWLFRFLVGQVDRIAPFRVSAAIVVVLLVVLTITLLNGVVLKFAMNSM
FT                   NSTFAAVNNEMNPDSAPPKTPLRSGGPGSLVSWESLGHQGRIFVHSGPTIADLTAFNGT
FT                   PAVEPIRTYAGLNSADGIMATAELAARELARTGGLRRAVVAVATSTGTGWINEAEASAL
FT                   EYMYNGDTAIVSMQYSFLPSWLSFLVDKENARHAGEALFEAVDKLIRQLPESQRPKLVV
FT                   FGESLGSFGGEAPFMNLNNILARTDGALFSGPTFNNTVWNSLTANRDAGSPQWLPIYDD
FT                   GRNVRFVARARDLQRPDAPWGRPRVVYLQHASDPIAWWTPRLLFREPDWLREQRGYDVL
FT                   PQTRWIPVVTFVQVSADMAVATHVPDGHGHRYVATVADGWAAVLSPPGWTQQKTERLQP
FT                   LLHANAKPFGS"
FT   CDS             complement(160483..161256)
FT                   /transl_table=11
FT                   /gene="echA8"
FT                   /locus_tag="Rv1070c"
FT                   /product="PROBABLE ENOYL-CoA HYDRATASE ECHA8 (ENOYL
FT                   HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)"
FT                   /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING
FT                   SPECIFIC COMPONENTS (BY SIMILARITY) [CATALYTIC ACTIVITY:
FT                   (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]."
FT                   /EC_number="4.2.1.17"
FT                   /note="Rv1070c, (MTV017.23c), len: 257 aa. Probable echA8,
FT                   enoyl-CoA hydratase (EC 4.2.1.17), equivalent to
FT                   O07137|B1306.05c putative enoyl-CoA hydratase/isomerase
FT                   from Mycobacterium leprae (257 aa), FASTA scores: opt:
FT                   1417, E(): 0, (86.4% identity in 257 aa overlap). Also
FT                   highly similar to others e.g. NP_106219.1|NC_002678 enoyl
FT                   CoA hydratase from Mesorhizobium loti (257 aa);
FT                   L39265|RHMRPST_2 enoyl-CoA hydratase from Rhizobium
FT                   melilotii (257 aa), FASTA scores: opt: 1100, E(): 0, (66.9%
FT                   identity in 257 aa overlap);
FT                   AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase
FT                   from Pseudomonas putida (257 aa); etc. Contains PS00166
FT                   Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE
FT                   ENOYL-CoA HYDRATASE/ISOMERASE FAMILY. TBparse score is
FT                   0.881."
FT                   /db_xref="GOA:P64016"
FT                   /db_xref="InterPro:IPR018376"
FT                   /db_xref="PDB:3H81"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64016"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17186.1"
FT                   /translation="MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELDD
FT                   DPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTADFFATWGKLAAVRTPTIAAVAGY
FT                   ALGGGCELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGR
FT                   TMDAAEAERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESSLSEG
FT                   LLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR"
FT   misc_feature    complement(160903..160965)
FT                   /note="PS00166 Enoyl-CoA hydratase/isomerase signature."
FT   CDS             complement(161268..162305)
FT                   /transl_table=11
FT                   /gene="echA9"
FT                   /locus_tag="Rv1071c"
FT                   /product="POSSIBLE ENOYL-CoA HYDRATASE ECHA9 (ENOYL
FT                   HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)"
FT                   /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING
FT                   SPECIFIC COMPONENTS (BY SIMILARITY) [CATALYTIC ACTIVITY:
FT                   (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]."
FT                   /EC_number="4.2.1.17"
FT                   /note="Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,
FT                   enoyl-CoA hydratase (EC 4.2.1.17), equivalent to
FT                   Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase
FT                   from Mycobacterium leprae (345 aa), FASTA scores: opt:
FT                   1799, E(): 0, (77.7% identity in 345 aa overlap). Also
FT                   similar to many eukaryotic and prokaryotic enoyl-CoA
FT                   hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA
FT                   hydratase protein from Sinorhizobium meliloti (356 aa);
FT                   NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family
FT                   protein from Caulobacter crescentus (350 aa); Q19278
FT                   PROTEIN SIMILAR TO ENOYL-CoA HYDRATASES from Caenorhabditis
FT                   elegans (386), FASTA scores: opt: 787, E(): 0, (38.5%
FT                   identity in 348 aa overlap); etc. TBparse score is 0.892."
FT                   /db_xref="GOA:O53419"
FT                   /db_xref="HSSP:1MJ3"
FT                   /db_xref="InterPro:IPR001753"
FT                   /db_xref="UniProtKB/TrEMBL:O53419"
FT                   /protein_id="CAA17187.1"
FT                   /translation="MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSW
FT                   EHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKDGVEARRFWRHEYLLNALIGRFAKP
FT                   YVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGALGL
FT                   HAALTGAPFSGADAIALGFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAA
FT                   QRDWIDECYAGDSVADIVAALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDT
FT                   LEDVLIQDYRVSSASLRSHDLVEGIRAQLIDKDRNPNWSPATLDAITAADIEAYFEPVD
FT                   DDLSF"
FT   CDS             162492..163328
FT                   /transl_table=11
FT                   /locus_tag="Rv1072"
FT                   /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1072, (MTV017.25), len: 278 aa. Probable conserved
FT                   transmembrane protein, equivalent to O07139|B1306.07|Y13803
FT                   Protein B1306.07 from Mycobacterium leprae (220 aa), FASTA
FT                   scores: opt:1032, E(): 0, (75.0% identity in 220 aa
FT                   overlap); and at the C-terminal end to Q50056|U1740D
FT                   Mycobacterium leprae (96 aa), FASTA scores: opt: 381, E():
FT                   1.2e-18, (71.6% identity in 81 aa overlap). Similar to
FT                   Q54192|M80628|STMBLDA_1 TRANSFER RNA-LEU (BLDA) GENE AND
FT                   ORF from Streptomyces griseus (293 aa), FASTA scores:
FT                   opt:558, E(): 4.7e-30, (41.5% identity in 299 aa overlap).
FT                   TBparse score is 0.896."
FT                   /db_xref="GOA:O53420"
FT                   /db_xref="InterPro:IPR010539"
FT                   /db_xref="UniProtKB/TrEMBL:O53420"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17188.1"
FT                   /translation="MRETSNPVFRSLPKQRGGYAQFGTGTAQQGFPADPYLAPYREAKA
FT                   TRPLTIDDVVTKTGLTLAMLAGTAVVSYFLVASNVALAMPLTLVGALGGLALVLVATFG
FT                   RKQDNPAIVLSYAALEGLFLGAISFVLANFTVASANAGVLIGEAILGTMGVFFGMLVVY
FT                   KTGAIRVTPKFTRMVVAALFGVLVLMLGNLVLAMFNVGGGEGLGLRSPGPLGIIFSLVC
FT                   IGIAAFSFLIDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYIEILRLLSYLQNE"
FT   CDS             163444..164295
FT                   /transl_table=11
FT                   /locus_tag="Rv1073"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1073, (MTV017.26), len: 283 aa. Conserved
FT                   hypothetical protein, similar to several hypothetical
FT                   mycobacterial proteins e.g. Rv1482c|Z79701|MTCY277.03
FT                   Mycobacterium tuberculosis (339 aa), FASTA scores: opt:
FT                   810, E(): 0, (47.4% identity in 272 aa overlap);
FT                   Rv3555c|Z92774|MTCY6G11_2 Mycobacterium tuberculosis (289
FT                   aa), FASTA scores: opt: 704, E(): 0, (44.4% identity in 259
FT                   aa overlap); and Rv3517, etc., and GIR10|AF002133_10
FT                   Mycobacterium avium strain GIR10 (346 aa), FASTA scores:
FT                   opt: 802, E(): 0, (48.1% identity in 270 aa overlap).
FT                   TBparse score is 0.942."
FT                   /db_xref="UniProtKB/TrEMBL:O53421"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17189.1"
FT                   /translation="MGAQPFIGSEALAAGLISWHELGKYYTAIMPNVYLDKRLKPSLRQ
FT                   RVIAAWLWSGRKGVIAGASASALHGAKWVDDHALVELIWRNARAPNGVRTKDELLLDGE
FT                   VQRLCGLTVTTVERTAFDLGRRPPLGQAITRLDALANATDFKINDVRELARKHPHTRGL
FT                   RQLDKALDLVDPGAQSPKETWLRLLLINAGFPRPSTQIPLLGVYGHPKYFLDMGWEDIM
FT                   LAVEYDGEQHRLSRDQFVKDVERLEYIRRAGWTHIRVLADHKGPDVVRRVRQAWDTLTS
FT                   RR"
FT   CDS             complement(164369..165586)
FT                   /transl_table=11
FT                   /gene="fadA3"
FT                   /locus_tag="Rv1074c"
FT                   /product="PROBABLE BETA-KETOACYL CoA THIOLASE FADA3"
FT                   /function="UNKNOWN, BUT SUPPOSED INVOLVED IN LIPID
FT                   DEGRADATION (BETA OXYDATION)."
FT                   /EC_number="2.3.1.-"
FT                   /note="Rv1074c, (MTV017.27c), len: 405 aa. Probable fadA3,
FT                   beta-ketoacyl CoA thiolase (EC 2.3.1.-), highly similar to
FT                   many involved in beta-oxidation e.g. CAB89028.1|AL353870
FT                   beta-ketoadipyl-CoA thiolase from Streptomyces coelicolor
FT                   (395 aa); P77525|PAAJ_ECOLI probable beta-ketoadipyl CoA
FT                   thiolase from Escherichia coli (401 aa), FASTA scores: opt:
FT                   1034, E(): 5.4e-56, (43.5% identity in 416 aa overlap) and
FT                   X97452 acetyl-CoA acetyltransferase (thiolase) from
FT                   Escherichia coli (401 aa), FASTA scores: opt: 1043, E(): 0,
FT                   (43.4% identity in 415 aa overlap); Q43935|CATF_ACICA
FT                   beta-ketoadipyl CoA thiolase from Acinetobacter
FT                   calcoaceticus (401 aa), FASTA scores: opt: 992, E(): 0,
FT                   (41.5% identity in 415 aa overlap); etc. Contains PS00737
FT                   Thiolases signature 2, and PS00445 FGGY family of
FT                   carbohydrate kinases signature 2, although this is probably
FT                   fortuitous. BELONGS TO THE THIOLASE FAMILY. TBparse score
FT                   is 0.875."
FT                   /db_xref="GOA:O53422"
FT                   /db_xref="HSSP:1AFW"
FT                   /db_xref="InterPro:IPR018483"
FT                   /db_xref="UniProtKB/TrEMBL:O53422"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17190.1"
FT                   /translation="MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPAL
FT                   NPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDFLPGTTVNRYCSSSLQTTRMAFHAI
FT                   KAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPRTDQ
FT                   KLPDIYIAMGQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDG
FT                   TTVSTDDGPRPGTTYEKVSELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGL
FT                   TPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAFAVQVLGSAR
FT                   ELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAM
FT                   VIERLA"
FT   misc_feature    complement(164489..164539)
FT                   /note="PS00737 Thiolases signature 2."
FT   misc_feature    complement(165467..165529)
FT                   /note="PS00445 FGGY family of carbohydrate kinases
FT                   signature 2"
FT   CDS             complement(165639..166583)
FT                   /transl_table=11
FT                   /locus_tag="Rv1075c"
FT                   /product="CONSERVED EXPORTED PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1075c, (MTV017.28c), len: 314 aa. Possibly
FT                   exported protein, as it contains a N-terminal signal
FT                   sequence, hydrophobic domain from aa 7-25. Similar to
FT                   U15183|MLU15183_2 Mycobacterium leprae cosmid B1740 (106
FT                   aa), FASTA scores: opt: 207, E(): 1.6e-06, (42.6% identity
FT                   in 101 aa overlap). Also weak similarity to many
FT                   glyceraldehyde-3-phosphate dehydrogenases e.g.
FT                   Q41595|G3PC_TAXBA Taxus baccata (340 aa), FASTA scores:
FT                   opt: 147, E(): 0.027, (27.5% identity in 189 aa overlap).
FT                   TBparse score is 0.916."
FT                   /db_xref="GOA:O53423"
FT                   /db_xref="InterPro:IPR001087"
FT                   /db_xref="UniProtKB/TrEMBL:O53423"
FT                   /protein_id="CAA17191.1"
FT                   /translation="MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSFD
FT                   APPRADGVYTRGGGPVQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGLAE
FT                   QTGKRIRLSTKAIVGATSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPSAQR
FT                   LADCVRRLRTRGAVVVVGTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAAGGVP
FT                   VPLGHLLAPKFRAMPELMFSADRYHPSAPAYALAADLLFLALRDALTEKLDIPIHETPS
FT                   RPGTATLEPGHTRHSMMSRLRRPRPARAVPTGG"
FT   CDS             166980..167873
FT                   /transl_table=11
FT                   /gene="lipU"
FT                   /locus_tag="Rv1076"
FT                   /product="POSSIBLE LIPASE LIPU"
FT                   /function="HYDROLYSES LIPIDS"
FT                   /EC_number="3.1.-.-"
FT                   /note="Rv1076, (MTV017.29), len: 297 aa. Possible lipU,
FT                   lipase (EC 3.1.-.-), very similar to several Mycobacterium
FT                   tuberculosis proteins e.g. Z95390|Rv3487c|MTCY13E12.41c
FT                   (277 aa), FASTA scores: opt: 1225, E(): 0, (76.0% identity
FT                   in 246 aa overlap); Rv1426c, etc. Also similar to esterases
FT                   and lipases of around 300 aa e.g. Q44087 ESTERASE PRECURSOR
FT                   from Acinetobacter lwoffii esterase (303), FASTA scores:
FT                   opt: 427, E(): 1.9e-21, (32.5% identity in 280 aa overlap).
FT                   Equivalent to AL035159|MLCB1450 _7 Mycobacterium leprae
FT                   (335 aa), FASTA scores: opt: 1588, E(): 0, (79.7% identity
FT                   in 296 aa overlap). TBparse score is 0.935."
FT                   /db_xref="GOA:O53424"
FT                   /db_xref="InterPro:IPR013094"
FT                   /db_xref="UniProtKB/TrEMBL:O53424"
FT                   /protein_id="CAA17192.1"
FT                   /translation="MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPASTTVRAAVSLPN
FT                   ASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSKFADSPVLVVDYRL
FT                   IPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSAGGYLALALAQRLQEVGEEPAAL
FT                   VAISPLLQLAKEHKQAHPNIKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLE
FT                   HITPGLPRTLIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEA
FT                   IRSLRQIGEYIREATG"
FT   CDS             167930..169324
FT                   /transl_table=11
FT                   /gene="cbs"
FT                   /locus_tag="Rv1077"
FT                   /standard_name="cysM2"
FT                   /product="Probable cystathionine beta-synthase CBS (Serine
FT                   sulfhydrase) (Beta-thionase) (Hemoprotein H-450)"
FT                   /function="THOUGHT TO BE INVOLVED IN HOMOCYSTEINE
FT                   TRANSULFURATION [CATALYTIC ACTIVITY: L-serine +
FT                   L-homocysteine = cystathionine + H2O]"
FT                   /EC_number="4.2.1.22"
FT                   /note="Rv1077, (MTV017.30), len: 464 aa. Probable cbs
FT                   (previously cysM2), cystathionine beta-synthase (EC
FT                   4.2.1.22), similar throughout its length to many eukaryotic
FT                   cystathionine beta-synthases e.g. P32232|CBS_RAT
FT                   CYSTATHIONINE BETA-SYNTHASE (560 aa), FASTA scores: opt:
FT                   951, E(): 0, (40.2% identity in 450 aa overlap); also
FT                   similar in N-terminal domain (aa 1 - 330) to
FT                   Rv2334|MTCY98.03 CysK Mycobacterium tuberculosis (310 aa),
FT                   FASTA scores: opt: 855, E(): 0, (46.8% identity in 314
FT                   overlap); and other cysteine synthase proteins e.g. Rv1336,
FT                   Rv0848, etc. Contains PS00217 Sugar transport proteins
FT                   signature 2 probably spurious. TBparse score is 0.891.
FT                   BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE
FT                   BETA-SYNTHASE FAMILY."
FT                   /db_xref="GOA:Q7D8W0"
FT                   /db_xref="HSSP:1O58"
FT                   /db_xref="InterPro:IPR005857"
FT                   /db_xref="UniProtKB/TrEMBL:Q7D8W0"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55353.1"
FT                   /translation="MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKD
FT                   RIAVKMIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDKRN
FT                   VLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPEGPASHYVTTGP
FT                   EIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRIVGADPEGSVYSGGAGRPYL
FT                   VEGVGEDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVA
FT                   EEAGPDALIVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGA
FT                   LPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGR
FT                   AKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLS
FT                   EGAGRR"
FT   misc_feature    168458..168535
FT                   /note="PS00217 Sugar transport proteins signature 2"
FT   CDS             169526..170248
FT                   /transl_table=11
FT                   /gene="pra"
FT                   /locus_tag="Rv1078"
FT                   /product="Probable Proline-rich antigen homolog pra"
FT                   /function="UNKNOWN"
FT                   /note="Rv1078, (MTV017.31), len: 240 aa. Probable pra,
FT                   Proline-rich antigen homolog, equivalent to X65546|MLPRAG_1
FT                   proline rich antigen from Mycobacterium leprae (249 aa),
FT                   FASTA scores: opt: 1162, E(): 3.3e-30, (64.8% identity in
FT                   253 aa overlap). Has potential hydrophobic domains. TBparse
FT                   score is 0.929."
FT                   /db_xref="InterPro:IPR010432"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53426"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17194.1"
FT                   /translation="MTEQPPPGGSYPPPPPPPGPSGGHEPPPAAPPGGSGYAPPPPPSS
FT                   GSGYPPPPPPPGGGAYPPPPPSAGGYAPPPPGPAIRTMPTESYTPWITRVLAAFIDWAP
FT                   YVVLVGIGWVIMLVTQTSSCVTSISEYDVGQFCVSQPSMIGQLVQWLLSVGGLAYLVWN
FT                   YGYRQGTIGSSIGKSVLKFKVVSETTGQPIGFGMSVVRQLAHFIDAIICFVGFLFPLWD
FT                   AKRQTLADKIMTTVCVPI"
FT   CDS             170280..171446
FT                   /transl_table=11
FT                   /gene="metB"
FT                   /locus_tag="Rv1079"
FT                   /product="PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS)
FT                   (O-SUCCINYLHOMOSERINE [THIOL]-LYASE)"
FT                   /function="INVOLVED IN METHIONINE BIOSYNTHESIS: CONVERTS
FT                   O-SUCCINYL-L-HOMOSERINE TO CYSTATHIONINE [CATALYTIC
FT                   ACTIVITY : O-SUCCINYL-L-HOMOSERINE + L-CYSTEINE =
FT                   CYSTATHIONINE + SUCCINATE (CAN ALSO USE HYDROGEN SULFIDE
FT                   AND METHANETHIOL AS SUBSTRATES)]."
FT                   /EC_number="2.5.1.48"
FT                   /note="Rv1079, (MTV017.32), len: 388 aa. Probable metB,
FT                   cystathionine gamma-synthase (EC 4.2.99.9) (see citation
FT                   below). P46807|METB_MYCLE CYSTATHIONINE GAMMA-SYNTHASE from
FT                   Mycobacterium leprae (EC 4.2.1.22) (388 aa), FASTA scores:
FT                   opt: 2220, E(): 0, (87.3% identity in 387 aa overlap). Also
FT                   similar to other Mycobacterium tuberculosis enzymes
FT                   involved in methionine synthesis e.g. Rv0391 and Rv3340.
FT                   Contains PS00868 Cys/Met metabolism enzymes
FT                   pyridoxal-phosphate attachment site. TBparse score is
FT                   0.909. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY."
FT                   /db_xref="GOA:P66875"
FT                   /db_xref="HSSP:1GC0"
FT                   /db_xref="InterPro:IPR015422"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66875"
FT                   /protein_id="CAA17195.1"
FT                   /translation="MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQD
FT                   GVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHV
FT                   VIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSI
FT                   ADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALV
FT                   TNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPS
FT                   VSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGV
FT                   ESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG"
FT   misc_feature    170877..170921
FT                   /note="PS00868 Cys/Met metabolism enzymes
FT                   pyridoxal-phosphate attachment site"
FT   CDS             complement(171517..172011)
FT                   /transl_table=11
FT                   /gene="greA"
FT                   /locus_tag="Rv1080c"
FT                   /product="PROBABLE TRANSCRIPTION ELONGATION FACTOR GREA
FT                   (Transcript cleavage factor greA)"
FT                   /function="NECESSARY FOR EFFICIENT RNA POLYMERASE
FT                   TRANSCRIPTION ELONGATION PAST TEMPLATE-ENCODED ARRESTING
FT                   SITES. THE ARRESTING SITES IN DNA HAVE THE PROPERTY OF
FT                   TRAPPING A CERTAIN FRACTION OF ELONGATING RNA POLYMERASES
FT                   THAT PASS THROUGH, RESULTING IN LOCKED TERNARY COMPLEXES.
FT                   CLEAVAGE OF THE NASCENT TRANCRIPT BY CLEAVAGE FACTORS SUCH
FT                   AS GREA OR GREB ALLOWS THE RESUMPTION OF ELONGATION FROM
FT                   THE NEW 3'TERMINUS. GREA RELEASES SEQUENCES OF 2 TO 3
FT                   NUCLEOTIDES"
FT                   /note="Rv1080c, (MTV017.33c), len: 164 aa. Probable greA,
FT                   transcription elongation factor G, closest to
FT                   P46808|GREA_MYCLE TRANSCRIPTION ELONGATION FACTOR G from
FT                   Mycobacterium leprae (202 aa), FASTA scores: opt: 1005,
FT                   E(): 0, (94.5% identity in 164 aa overlap); and similar to
FT                   many e.g. P21346|GREA_ECOLI from Escherichia coli (158 aa),
FT                   FASTA scores: opt: 257, E(): 5.7e-10, (37.2% identity in
FT                   148 aa overlap); etc. Contains two PS00829 and one PS00830
FT                   Prokaryotic transcription elongation factors signatures 1
FT                   and 2, respectively. BELONGS TO THE GREA/GREB FAMILY.
FT                   TBparse score is 0.892."
FT                   /db_xref="GOA:P64279"
FT                   /db_xref="HSSP:1GRJ"
FT                   /db_xref="InterPro:IPR018151"
FT                   /db_xref="UniProtKB/Swiss-Prot:P64279"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17196.1"
FT                   /translation="MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDLR
FT                   ENGGYHAAREEQGQQEARIRQLQDLLSNAKVGEAPKQSGVALPGSVVKVYYNGDKSDSE
FT                   TFLIATRQEGVSDGKLEVYSPNSPLGGALIDAKVGETRSYTVPNGSTVSVTLVSAEPYH
FT                   S"
FT   misc_feature    complement(171592..171642)
FT                   /note="PS00830 Prokaryotic transcription elongation factors
FT                   signature 2"
FT   misc_feature    complement(171862..171984)
FT                   /note="PS00829 Prokaryotic transcription elongation factors
FT                   signature 1"
FT   CDS             complement(172197..172631)
FT                   /transl_table=11
FT                   /locus_tag="Rv1081c"
FT                   /product="PROBABLE CONSERVED MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1081c, (MTV017.34c), len: 144 aa. Probable
FT                   conserved membrane protein, with hydrophobic stretch from
FT                   aa 26 - 48, highly similar to NP_302548.1|NC_002677
FT                   conserved membrane protein from Mycobacterium leprae.
FT                   TBparse score is 0.906."
FT                   /db_xref="UniProtKB/TrEMBL:O53429"
FT                   /protein_id="CAA17197.1"
FT                   /translation="MTHTPIPRPDARYGRPRLSRRARRRVAIALGVLVAAAGIVIAVIG
FT                   YQRISTSAVTGSLVGYRLVDDETASVTISVTRSDPSRPVACIVRVRATNGSETGRRELL
FT                   VPPSEATTVQVTTTVKSSQPPVMADVYGCGTEVPSYLRLP"
FT   CDS             172733..173599
FT                   /transl_table=11
FT                   /gene="mca"
FT                   /locus_tag="Rv1082"
FT                   /product="Mycothiol conjugate amidase Mca (Mycothiol
FT                   S-conjugate amidase)"
FT                   /function="Mycothiol-dependent detoxification enzyme,
FT                   involved in mycothiol biosynthesis."
FT                   /note="Rv1082, (MTV017.35), len: 288 aa. mca, mycothiol
FT                   conjugate amidase (see citation below), equivalent to
FT                   NP_302547.1|NC_002677 conserved hypothetical protein from
FT                   Mycobacterium leprae (290 aa), FASTA scores: opt: 1737,
FT                   E(): 0, (86.4% identity in 287 aa overlap); and similar to
FT                   Q54358|X79146 lmbE protein from Streptomyces lincolnensis
FT                   (270 aa). Also similar to Rv1170|MTV005.06|MSHB GlcNAc-Ins
FT                   deacetylase from Mycobacterium tuberculosis (303 aa), FASTA
FT                   scores: opt: 411, E(): 9.4e-20, (35.8% identity in 299 aa
FT                   overlap). TBparse score is 0.896."
FT                   /db_xref="HSSP:1UAN"
FT                   /db_xref="InterPro:IPR017811"
FT                   /db_xref="UniProtKB/TrEMBL:O53430"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17198.1"
FT                   /translation="MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGERG
FT                   EILNPAMDLPDVHGRIAEIRRDEMTKAAEILGVEHTWLGFVDSGLPKGDLPPPLPDDCF
FT                   ARVPLEVSTEALVRVVREFRPHVMTTYDENGGYPHPDHIRCHQVSVAAYEAAGDFCRFP
FT                   DAGEPWTVSKLYYVHGFLRERMQMLQDEFARHGQRGPFEQWLAYWDPDHDFLTSRVTTR
FT                   VECSKYFSQRDDALRAHATQIDPNAEFFAAPLAWQERLWPTEEFELARSRIPARPPETE
FT                   LFAGIEP"
FT   CDS             173596..173862
FT                   /transl_table=11
FT                   /locus_tag="Rv1083"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1083, (MTV017.36), len: 88 aa. Conserved
FT                   hypothetical protein, similar to U15183|MLU15183_9
FT                   hypothetical protein from Mycobacterium leprae (167 aa),
FT                   FASTA scores: opt: 332, E(): 1.2e-13, (58.4% identity in
FT                   101 aa overlap). Hydrophobic domain aa 25-43. TBparse score
FT                   is 0.905."
FT                   /db_xref="UniProtKB/TrEMBL:O53431"
FT                   /protein_id="CAA17199.1"
FT                   /translation="MNQILLSVIAEGGPGNTGPDFGKASPVGLLVIVLLVIATLFLVRS
FT                   MNQQLKKVPKSFDRDHPELDQAADEGTDRDGPARPPGPPHESG"
FT   CDS             173849..175870
FT                   /transl_table=11
FT                   /locus_tag="Rv1084"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1084, (MTV017.37), len: 673 aa. Conserved
FT                   hypothetical protein, similar to P37512|YYAL_BACSU
FT                   hypothetical protein from Bacillus subtilis (689 aa), FASTA
FT                   scores: opt: 1063, E() : 0, (36.5% identity in 696 aa
FT                   overlap); AE0009|AE000983_10 Archaeoglobus fulgidus section
FT                   1 (642 aa), FASTA scores: opt: 1018, E(): 0, (37.2%
FT                   identity in 600 aa overlap). Also similar to
FT                   AE001938|AE001938_9 Deinococcus radiodurans (690 aa), FASTA
FT                   scores: opt: 1097, E(): 0, (41.6% identity in 694 aa
FT                   overlap). TBparse score is 0.872."
FT                   /db_xref="GOA:O53432"
FT                   /db_xref="InterPro:IPR012335"
FT                   /db_xref="UniProtKB/TrEMBL:O53432"
FT                   /protein_id="CAA17200.1"
FT                   /translation="MSPANPSGTNTLALATSPYLRQHADNPVHWQQWTPQALAEAAARA
FT                   VPILLSVGYAACHWCHVMAHESFDDDEVAAAMNAGFVCIKVDREERPDIDAVYMNATVA
FT                   LTGQGGWPMTCFLTPNGRPFFCGTYYPKAAFLQLLSAISETWRERRAEVEQASDHIAAE
FT                   LRSMASGLPGGGPEVAPELCDDAVAGVLREQDTAHGGFGGAPKFPPSALLEALMRHYER
FT                   TRSPAALEAVARTGNAMARGGIYDQLGGGFARYSVDGAWVVPHFEKMLYDNALLLRAYA
FT                   HWARRTGDPLARRVAAQTARFLLDELGSKAPADMFTSSLDADADGREGSTYVWTPVQLT
FT                   EVLGGDDGRWAAEVFGVTEAGTFEHGTSVLQLPADPDDAARLDRVRAALLVARLARAQP
FT                   ARDDKVVTSWNGLAITALAEASVALDDPALAHAARRCATRLLDLHVVDGRLRRASLGGV
FT                   VGDSAAILEDHAMLATGLLALYQLTSEGAWLTAATGLLDTAVAHFGDPQRPGRWFDTAD
FT                   DAERLMLRPSDPLDGATPSGASSIAEALLTAGHVVDGARAERYWQLAADTLRAHAVLLA
FT                   RAPRSAGHWLAVAEAVVRGPLQIAVACDLPRSSLLADARRLAPGGAIVVGGAAGSSALL
FT                   VGRDRVAGADAAYVCRGRVCDLPVTSAAELATALGVPG"
FT   CDS             complement(175969..176697)
FT                   /transl_table=11
FT                   /locus_tag="Rv1085c"
FT                   /product="POSSIBLE HEMOLYSIN-LIKE PROTEIN"
FT                   /function="NOT KNOWN, BUT SUPPOSED INVOLVED IN VIRULENCE"
FT                   /note="Rv1085c, (MTV017.38c), len: 242 aa. Possible
FT                   hemolysin-like protein, integral membrane protein, similar
FT                   to many hemolysins, and hypothetical proteins e.g.
FT                   U28375|ECU28375_49 Hypothetical protein from Escherichia
FT                   coli (219 aa), FASTA scores: opt: 308, E(): 7.5e-15, (30.6%
FT                   identity in 180 aa overlap); AE0011|HIAE001124_2
FT                   Hypothetical protein from Borrelia burgdorferi (233 aa),
FT                   FASTA scores: opt: 305, E(): 1.3e-14, (25.6% identity in
FT                   203 aa overlap). Also weakly similar to HLY3_BACCE|P54176
FT                   haemolysin from Bacillus cereus (219 aa), FASTA scores:
FT                   opt: 247, E(): 8.7e-12, (27.5% identity in 171 aa overlap).
FT                   Also similar to AE002027|AE002027_8 probable hemolysin from
FT                   Deinococcus radiodurans (219 aa), FASTA scores: opt: 354,
FT                   E(): 1.8e-16, (31.1% identity in 219 aa overlap). TBparse
FT                   score is 0.884."
FT                   /db_xref="GOA:P67157"
FT                   /db_xref="InterPro:IPR005744"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67157"
FT                   /protein_id="CAA17201.1"
FT                   /translation="MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYSA
FT                   GTAVLAGASLVAVSWAVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWMKR
FT                   ADHSMIFVFIAGSYTPFALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVGVPL
FT                   YLLLGWVAVWYTATILHNAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGYHEFF
FT                   HACTAVAAICHYIAMWFVVF"
FT   CDS             176808..177596
FT                   /transl_table=11
FT                   /locus_tag="Rv1086"
FT                   /product="SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE
FT                   SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE)
FT                   (Z-FPP SYNTHETASE) (Z-FARNESYL DIPHOSPHATE SYNTHETASE)
FT                   (GERANYLTRANSTRANSFERASE) (FARNESYL PYROPHOSPHATE
FT                   SYNTHETASE)"
FT                   /function="CATALYZES THE FIRST COMMITTED STEP IN THE
FT                   SYNTHESIS OF DECAPRENYL DIPHOSPHATE, A MOLECULE WHICH HAS A
FT                   CENTRAL ROLE IN THE BIOSYNTHESIS OF MOST FEATURES OF THE
FT                   MYCOBACTERIAL CELL WALL. ADDS ONE ISOPRENE UNIT TO
FT                   OMEGA,E-GERANYL DIPHOSPHATE. THE PRODUCT, OMEGA,E,
FT                   Z-FARNESYL DIPHOSPHATE, IS THE PUTATIVE SUBSTRATE OF
FT                   Rv2361c PRODUCT [CATALYTIC ACTIVITY: Geranyl diphosphate +
FT                   isopentenyl diphosphate = diphosphate +
FT                   trans,trans-farnesyl diphosphate]."
FT                   /EC_number="2.5.1.10"
FT                   /note="Rv1086, (MTV017.39), len: 262 aa. Short (C15) chain
FT                   Z-isoprenyl diphosphate synthase (EC 2.5.1.10) (see
FT                   citations below), equivalent to NP_302598.1|NC_002677
FT                   possible undecaprenyl pyrophosphate synthetase from
FT                   Mycobacterium leprae (262 aa), similar to many hypothetical
FT                   proteins and several potential members of the upp synthase
FT                   family e.g. NP_296167.1|NC_001263 undecaprenyl diphosphate
FT                   synthase from Deinococcus radiodurans (339 aa);
FT                   P20182|YT14_STRFR Hypothetical protein from Streptomyces
FT                   fradiae (259 aa), FASTA scores: opt: 840, E(): 0, (51.0%
FT                   identity in 259 aa overlap); and P38118|YARF_CORGL
FT                   Hypothetical protein from Corynebacterium glutamicicum (234
FT                   aa), FASTA scores: opt: 729, E(): 0, (56.0% identity in 209
FT                   aa overlap); etc. Also similar to Rv2361c|MTCY27.19 (296
FT                   aa) (35.6% identity in 233 aa overlap). Contains PS01066
FT                   Uncharacterized protein family UPF0015 signature. SEEMS TO
FT                   BELONG TO THE UPP SYNTHETASE FAMILY."
FT                   /db_xref="GOA:O53434"
FT                   /db_xref="InterPro:IPR018520"
FT                   /db_xref="PDB:2VFW"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53434"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17202.1"
FT                   /translation="MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRW
FT                   ARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEII
FT                   TDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRRE
FT                   IVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFL
FT                   LWQSAYSEMWFTEAHWPAFRHVDFLRALRDYSARHRSYGR"
FT   misc_feature    177426..177482
FT                   /note="PS01066 Uncharacterized protein family UPF0015
FT                   signature"
FT   CDS             177773..180076
FT                   /transl_table=11
FT                   /gene="PE_PGRS21"
FT                   /locus_tag="Rv1087"
FT                   /product="PE-PGRS FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1087, (MTV017.40), len: 767 aa. Member of the
FT                   Mycobacterium tuberculosis PE family, PGRS subfamily of
FT                   gly-rich proteins (see citation below). Similar to
FT                   Rv1090|AL021897|MTV017_43 Mycobacterium tuberculosis H37Rv
FT                   (853 aa), FASTA scores: opt: 2819, E(): 0, (59.8% identity
FT                   in 860 aa overlap). Contains PS00583 pfkB family of
FT                   carbohydrate kinases signature 1 near C -terminus. TBparse
FT                   score is 0.859."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FT0"
FT                   /protein_id="CAE55354.1"
FT                   /translation="MSFVVVAPEVLAAAASDLAGIGSTLAQANAAALAPTTAVLAAGAD
FT                   EVSAAIASLFGAHGQAYQAVSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVEQD
FT                   LLAAINARFERIFGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTVGMAGGNGGAA
FT                   GLIGNGGFGGGGGPGAAGGNGGAGGWLFGNGGAGGAGGLGVAPGVPGGAGGAGGAGGVG
FT                   GPAGLWGHGGAGGAGGAGVAGAGGFEGTIGAGGAGGVGGAGGVGGAGGAGGWLYGDAGA
FT                   GGDGGVGGAGGTGGLGNRGGAGGAGGAGGVGGAGGAAGLWGGGGAGGVGGTGGGAGLGA
FT                   QSVTFSSSLSGLSGGDGGAGGAGGAGGAGGTGGWLYGGGGAAGSGGDGGTGGQGGAGGA
FT                   GVFSLFGSGGGPGGNGGVGGVGGVGGAGGRAGLFGVGGLGGAGGDAGDSGEGGFGGPGL
FT                   AGGLFGNPGNGGVGGIGGDAAAGGAGGAGGNGGAGGNGGWLFGNGGAGGSGGDGGAAGR
FT                   GGAGNLGSAGGINAPAGNPGSGSVGIGGAGGAGGTAGLFGDGGAGGAGGAGAAGGFGGI
FT                   SAATPSAGSEGAMGGAGGVGGNARLLGTGGAGGVGGGGGAGGDGGRGGVATPGGQGGDA
FT                   GDGGAGGAGGNGGGASGAGGWLLGTGGAGGAGGNGGNGGKAGFSPGPTNFGLNGAGGGG
FT                   GVGGNGATGPWLFGDGGPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGGAG
FT                   GLSGLLFGEPGANG"
FT   misc_feature    179852..179926
FT                   /note="PS00583 pfkB family of carbohydrate kinases
FT                   signature 1"
FT   CDS             180253..180573
FT                   /transl_table=11
FT                   /locus_tag="Rv1087A"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1087A, 106 aa (fragment). Conserved hypothetical
FT                   protein, highly similar to C-terminus of near ORF
FT                   O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 SHORT (C15) CHAIN
FT                   Z-ISOPRENYL DIPHOSPHATE SYNTHASE from Mycobacterium
FT                   tuberculosis (262 aa), FASTA scores: opt: 200, E():
FT                   1.1e-06, (57.9% identity in 76 aa overlap)."
FT                   /db_xref="GOA:Q8VK75"
FT                   /db_xref="HSSP:1F75"
FT                   /db_xref="InterPro:IPR001441"
FT                   /db_xref="UniProtKB/TrEMBL:Q8VK75"
FT                   /protein_id="CAE55355.1"
FT                   /translation="MPCVGYGDRREFVDAVAVEAICENLNTSGQPDPDLVIRTSGEQRL
FT                   SGHRGPTGGVSRRRLLRALRDYSTPHASIPYVPPPYRSDGIHASRLAVESVFDALAGRV
FT                   EL"
FT   CDS             180726..181160
FT                   /transl_table=11
FT                   /gene="PE9"
FT                   /locus_tag="Rv1088"
FT                   /product="PE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1088, (MTV017.41), len: 144 aa. Member of
FT                   Mycobacterium tuberculosis PE family (see citation below),
FT                   similar to many others e.g. Z96071|MTCI418B_6 Mycobacterium
FT                   tuberculosis cosmid (487 aa), FASTA scores: opt: 318, E():
FT                   7.3e-14, (60.9% identity in 87 aa overlap) - except it
FT                   appears to be frameshifted around codon 84. No error to
FT                   account for frameshift could be found. TBparse score is
FT                   0.943"
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FS8"
FT                   /protein_id="CAE55356.1"
FT                   /translation="MSYMIATPAALTAAATDIDGIGSAVSVANAAAVAATTGVLAAGGD
FT                   EVLAAIARLFNANAEEYHALSAQVAAFQTLFVRTLTGGCGVFRRRRGRQCVTAAEHRAA
FT                   GAGRRQRRRRSGDGQWRLRQQRHFGCGGQPEFRQHSEHRR"
FT   CDS             <180982..181344
FT                   /transl_table=11
FT                   /gene="PE10"
FT                   /locus_tag="Rv1089"
FT                   /product="PE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1089, (MTV017.42), len: 120 aa. Member of the
FT                   Mycobacterium tuberculosis PE family of glycine-rich
FT                   proteins (see citation below). Partial ORF that appears to
FT                   be frameshifted continuation of Rv1088|MTV017.41. Sequence
FT                   has been checked and appears correct. Similar to
FT                   Z95555|MTCY06F7_4 Mycobacterium tuberculosis cosmid (401
FT                   aa), FASTA scores: opt:126, E(): 2, (29.6% identity in 125
FT                   aa overlap)."
FT                   /db_xref="GOA:Q79FS7"
FT                   /db_xref="InterPro:IPR001919"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FS7"
FT                   /protein_id="CAE55357.1"
FT                   /translation="SFAGAEAANASQLQSIARQVRGAVNAVAGQVTGNGGSGNSGTSAA
FT                   AANPNSDNTASIADRGTSAIMTTASATASSTGVDGGIAATYAVASQWDGGYVANYTITQ
FT                   FGRDFDDRLAVAIHFA"
FT   CDS             181730..181834
FT                   /transl_table=11
FT                   /gene="celA2a"
FT                   /locus_tag="Rv1089A"
FT                   /product="PROBABLE CELLULASE CELA2A
FT                   (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL
FT                   CELLULASE)"
FT                   /function="THE BIOLOGICAL CONVERSION OF CELLULOSE TO
FT                   GLUCOSE GENERALLY REQUIRES THREE TYPES OF HYDROLYTIC
FT                   ENZYMES: (1) ENDOGLUCANASES WHICH CUT INTERNAL
FT                   BETA-1,4-GLUCOSIDIC BONDS; (2) EXOCELLOBIOHYDROLASES THAT
FT                   CUT THE DISSACCHARIDE CELLOBIOSE FROM THE NONREDUCING END
FT                   OF THE CELLULOSE POLYMER CHAIN; (3) BETA-1,4-GLUCOSIDASES
FT                   WHICH HYDROLYZE THE CELLOBIOSE AND OTHER SHORT
FT                   CELLO-OLIGOSACCHARIDES TO GLUCOSE [CATALYTIC
FT                   ACTIVITY:Endohydrolysis of 1,4-beta-D-glucosidic linkages
FT                   in cellulose]."
FT                   /EC_number="3.2.1.4"
FT                   /note="Rv1089A, len: 34 aa. Probable celA2a, first part of
FT                   cellulase (endoglucanase) (EC 3.2.1.4), similar to
FT                   N-terminus of others."
FT                   /db_xref="GOA:Q79FS6"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FS6"
FT                   /protein_id="CAE55358.1"
FT                   /translation="MNGAAPTNGAPLSYPSICEGVHWGHLVGGHQPAY"
FT   CDS             181812..182267
FT                   /transl_table=11
FT                   /gene="celA2b"
FT                   /locus_tag="Rv1090"
FT                   /product="PROBABLE CELLULASE CELA2B
FT                   (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL
FT                   CELLULASE)"
FT                   /function="THE BIOLOGICAL CONVERSION OF CELLULOSE TO
FT                   GLUCOSE GENERALLY REQUIRES THREE TYPES OF HYDROLYTIC
FT                   ENZYMES: (1) ENDOGLUCANASES WHICH CUT INTERNAL
FT                   BETA-1,4-GLUCOSIDIC BONDS; (2) EXOCELLOBIOHYDROLASES THAT
FT                   CUT THE DISSACCHARIDE CELLOBIOSE FROM THE NONREDUCING END
FT                   OF THE CELLULOSE POLYMER CHAIN; (3) BETA-1,4-GLUCOSIDASES
FT                   WHICH HYDROLYZE THE CELLOBIOSE AND OTHER SHORT
FT                   CELLO-OLIGOSACCHARIDES TO GLUCOSE [CATALYTIC
FT                   ACTIVITY:Endohydrolysis of 1,4-beta-D-glucosidic linkages
FT                   in cellulose]."
FT                   /EC_number="3.2.1.4"
FT                   /note="Rv1090, (MTV017.43), len: 151 aa. Probable celA2b,
FT                   second part of cellulase (endoglucanase) (EC 3.2.1.4),
FT                   similar to C-terminus of others e.g. O08468 cellulase CEL2
FT                   from Streptomyces halstedi (377 aa), FASTA scores: opt:
FT                   554, E(): 1.2e-30, (52.0% identity in 152 aa overlap); etc.
FT                   TBparse score is 0.876. Gene appears to have been
FT                   inactivated by frameshift mutations but no errors could be
FT                   found that would account for this."
FT                   /db_xref="GOA:O53438"
FT                   /db_xref="HSSP:1OA4"
FT                   /db_xref="InterPro:IPR013319"
FT                   /db_xref="UniProtKB/TrEMBL:O53438"
FT                   /protein_id="CAA17206.1"
FT                   /translation="MGTNLPTEVGQILSAPTSIDYNYPTTGVWDASYDICLDSTPKTTG
FT                   VNQQEIMIWFNHQGSIQPVGSPVGNTTIEGKNFVVWDGSNGMNNAMAYVATEPIEVWSF
FT                   DVMSFVDHTATMEPITDSWYLTSIRAGLEPWSDGVGLGVDSFSAKVN"
FT   CDS             182682..185243
FT                   /transl_table=11
FT                   /gene="PE_PGRS22"
FT                   /locus_tag="Rv1091"
FT                   /product="PE-PGRS FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1091, (MTV017.44), len: 853 aa. Member of the
FT                   Mycobacterium tuberculosis PE family, PGRS subfamily of
FT                   gly-rich proteins (see citation below). Similar to
FT                   Rv1087|AL021897|MTV017_39 Mycobacterium tuberculosis H37Rv
FT                   (767 aa), FASTA scores: opt: 2819, E(): 0, (60.0% identity
FT                   in 860 aa overlap). TBparse score is 0.859."
FT                   /db_xref="InterPro:IPR000084"
FT                   /db_xref="UniProtKB/TrEMBL:Q79FS5"
FT                   /protein_id="CAE55359.1"
FT                   /translation="MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALLAAGAD
FT                   EVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAAEAANVSAAQSTDQR
FT                   LLDLINGPTQALLGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAA
FT                   GLIGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIPGVAGGNGGAGGSAGLW
FT                   GTGGAGGDGGNGRSGPVNVAGSAGGNGGAGGAAGLFGDAGAGGNGGKGGAGGAAFSINF
FT                   TAGDGGAGGAGGSGGHALLWGAGGAGGNGGSGGTGGAGGSTAGAGGNGGAGGGGGTGGL
FT                   LFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGGAGGDGGAGGAGGNARLWGVGGA
FT                   GGAGGDGGAGGAGGKGGSGLSGNANGGAGGDSGRGGTGGAGGEGGAAGLLVGTGGHGGD
FT                   GGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGGSGGDGGGGAAGPAGWLFGDGGAGG
FT                   NGGAAAAGGAGGQAGGGGGNGGNGGNGGNGGNGGNGATGGWLYGNGGAGGQGATAGAGG
FT                   AGANGVSSTNGGGTGGNGGIGGTGGSGGAGGNAGLLGVGGAGGHGASGGAGDRGGAGGT
FT                   GFISSDGGAGGDGGDGGNGGAGGTGGLLFGAGGNGGPGGSGGAADIGGNGGAGNGGGTD
FT                   GNGGNGGSGGGAGSGGDGGGAGGNGAWLFGNGGAGGGGGKGGNGAGGGLGGGSFGLPGL
FT                   NGSGGDGGDGGNGAPGGVLYGNGGAGGQGSSGGIGGPGATGGAGGKGGDGGDAQLIGDG
FT                   GNGGNGGAGGTGGTPGPGGPGGSGGLGGLLFGQTGTAGVSP"
FT   CDS             complement(185461..186399)
FT                   /transl_table=11
FT                   /gene="coaA"
FT                   /locus_tag="Rv1092c"
FT                   /product="Probable pantothenate kinase coaA (Pantothenic
FT                   acid kinase)"
FT                   /function="Coenzyme A (CoA) biosynthesis [CATALYTIC
FT                   ACTIVITY : ATP + PANTOTHENATE = ADP + D-4'-
FT                   PHOSPHOPANTOTHENATE.]"
FT                   /EC_number="2.7.1.33"
FT                   /note="Rv1092c, (MTV017.45c), len: 312 aa. Probable coaA,
FT                   pantothenate kinase (EC 2.7.1.33), similar to many e.g.
FT                   P15044|COAA_ECOLI Escherichia coli (316 aa), FASTA scores
FT                   :opt: 1079, E(): 0, (52.7% identity in 311 aa overlap).
FT                   Equivalent to AL049491|MLCB1222_17 Mycobacterium leprae
FT                   (312 aa) (93.6% identity in 312 aa overlap). Contains
FT                   PS00017 ATP/GTP-binding site motif A (P-loop). TBparse
FT                   score is 0.912. BELONGS TO THE PANTOTHENATE KINASE FAMILY."
FT                   /db_xref="GOA:P63810"
FT                   /db_xref="InterPro:IPR004566"
FT                   /db_xref="PDB:2GES"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63810"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17208.1"
FT                   /translation="MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQID
FT                   LLEVEEVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVGKS
FT                   TTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNRRALMRFVT
FT                   SVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNVLQTGPTLMVSDLFDFSL
FT                   YVDARIEDIEQWYVSRFLAMRTTAFADPESHFHHYAAFSDSQAVVAAREIWRTINRPNL
FT                   VENILPTRPRATLVLRKDADHSINRLRLRKL"
FT   misc_feature    complement(186088..186111)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             186787..188067
FT                   /transl_table=11
FT                   /gene="glyA1"
FT                   /locus_tag="Rv1093"
FT                   /standard_name="glyA"
FT                   /product="Probable Serine hydroxymethyltransferase 1 glyA1"
FT                   /function="INTERCONVERSION OF SERINE AND GLYCINE. KEY
FT                   ENZYME IN THE BIOSYNTHESIS OF PURINES, LIPIDS, HORMONES AND
FT                   OTHER COMPONENTS [CATALYTIC ACTIVITY:
FT                   5,10-METHYLENETETRAHYDROFOLATE + GLYCINE + H(2)O =
FT                   TETRAHYDROFOLATE + L-SERINE.]"
FT                   /EC_number="2.1.2.1"
FT                   /note="Rv1093, (MTV017.46), len: 426 aa. Probable glyA1,
FT                   serine hydroxymethyltransferase 1 (EC 2.1.2.1), equivalent
FT                   to AL049491|MLCB1222_16 from Mycobacterium leprae (426 aa),
FT                   FASTA score: (89.9 % identity in 426 aa overlap). Also
FT                   similar to many e.g. P34895|GLYA_HYPME HYPHOMICROBIUM
FT                   METHYLOVORUM (434 aa), FASTA scores: opt: 1492, E(): 0,
FT                   (56.8% identity in 419 aa overlap); etc. BELONGS TO THE
FT                   SHMT FAMILY. Note that previously known as glyA. TBparse
FT                   score is 0.880."
FT                   /db_xref="GOA:O53441"
FT                   /db_xref="InterPro:IPR019798"
FT                   /db_xref="PDB:1LXB"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53441"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAE55360.1"
FT                   /translation="MSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFVPRAVLQAQG
FT                   SVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLH
FT                   ALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEF
FT                   RPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVS
FT                   TTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFAD
FT                   RQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEV
FT                   GITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVS
FT                   ALKDRATRLARAFPLYDGLEEWSLVGR"
FT   CDS             188172..188999
FT                   /transl_table=11
FT                   /gene="desA2"
FT                   /locus_tag="Rv1094"
FT                   /product="POSSIBLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE
FT                   DESA2 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE)"
FT                   /function="THOUGHT TO CATALYZE THE PRINCIPAL CONVERSION OF
FT                   SATURATED FATTY ACIDS TO UNSATURATED FATTY ACIDS. THOUGHT
FT                   TO CONVERT STEAROYL-ACP TO OLEOYL-ACP BY INTRODUCTION OF A
FT                   CIS DOUBLE BOND BETWEEN CARBONS DELTA-9 AND DELTA-10 OF THE
FT                   ACYL CHAIN [CATALYTIC ACTIVITY: Stearoyl-[acyl-carrier
FT                   protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + A + 2
FT                   H2O]."
FT                   /EC_number="1.14.19.2"
FT                   /note="Rv1094, (MTV017.47), len: 275 aa. Possible desA2,
FT                   acyl-[acyl-carrier protein] desaturase (stearoyl-ACP
FT                   desaturase) (EC 1.14.99.6), equivalent to
FT                   AL049491|MLCB1222_15 from Mycobacterium leprae (275 aa),
FT                   FASTA score: (78.1% identity in 274 aa overlap). Also
FT                   weakly similar to plant stearoyl-acyl carrier protein
FT                   desaturases, and very similar to U49839|MTV043.16C|Rv0824c
FT                   enzyme desA1 from Mycobacterium tuberculosis (338 aa),
FT                   FASTA scores: opt: 525, E(): 8.5e-30, (32.2% identity in
FT                   270 aa overlap); and to U15182|MLU15182_32 acyl-carrier
FT                   protein desaturase precursor from Mycobacterium leprae (338
FT                   aa), FASTA scores: opt: 506, E(): 1.9e-28, (34.1% identity
FT                   in 261 aa overlap). TBparse score is 0.894."
FT                   /db_xref="GOA:O53442"
FT                   /db_xref="InterPro:IPR012348"
FT                   /db_xref="PDB:1ZA0"
FT                   /db_xref="UniProtKB/TrEMBL:O53442"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17210.1"
FT                   /translation="MAQKPVADALTLELEPVVEANMTRHLDTEDIWFAHDYVPFDQGEN
FT                   FAFLGGRDWDPSQSTLPRTITDACEILLILKDNLAGHHRELVEHFILEDWWGRWLGRWT
FT                   AEEHLHAIALREYLVVTREVDPVANEDVRVQHVMKGYRAEKYTQVETLVYMAFYERCGA
FT                   VFCRNLAAQIEEPILAGLIDRIARDEVRHEEFFANLVTHCLDYTRDETIAAIAARAADL
FT                   DVLGADIEAYRDKLQNVADAGIFGKPQLRQLISDRITAWGLAGEPSLKQFVTG"
FT   CDS             189210..190511
FT                   /transl_table=11
FT                   /gene="phoH2"
FT                   /locus_tag="Rv1095"
FT                   /product="PROBABLE PHOH-LIKE PROTEIN PHOH2 (PHOSPHATE
FT                   STARVATION-INDUCIBLE PROTEIN PSIH)"
FT                   /function="FUNCTION NOT REALLY KNOWN."
FT                   /note="Rv1095, (MTV017.48), len: 433 aa. Probable phoH2,
FT                   phoH-like protein (phosphate starvation-induced protein),
FT                   probably ATP-binding protein. Equivalent to AL049491
FT                   MLCB1222_14 Mycobacterium leprae (433 aa) (92.8% identity
FT                   in 432 aa overlap). Similar to many proteins described as
FT                   PhoH-like e.g. Z97025|BSZ97025_12 Bacillus subtilis (442
FT                   aa), FASTA scores: opt: 605, E(): 0, (40.1% identity in 444
FT                   aa overlap); or Mycobacterium tuberculosis
FT                   Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352
FT                   aa), FASTA scores: opt: 390, E(): 4e-19, (31.5% identity in
FT                   241 aa overlap). Contains PS00017 ATP/GTP-binding site
FT                   motif A (P-loop). TBparse score is 0.885. BELONGS TO THE
FT                   PHOH FAMILY."
FT                   /db_xref="GOA:O53443"
FT                   /db_xref="InterPro:IPR006596"
FT                   /db_xref="UniProtKB/TrEMBL:O53443"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17211.1"
FT                   /translation="MTDTRTYVLDTSVLLSDPWACSRFAEHDVVVPLVVISELEAKRHH
FT                   HELGWFARQALRLFDDLRLEHGRLDQPIPVGTQGGTLHVELNHTDPAVLPAGFRTDSND
FT                   SRILSCAANLAAEGKRVTLVSKDIPLRVKAAAVGLAADEYHAQDVVVSGWSGMHELETA
FT                   SADIDALFADGEIDLVEARDLPCHTGIRLLGGGSHALGRVNAHKRVQLVRGDREAFGLR
FT                   GRSAEQRVALDLLLDESVGIVSLGGKAGTGKSALALCAGLEAVLERRTHRKVVVFRPLY
FT                   AVGGQELGYLPGSESEKMGPWAQAVFDTLEGLASPAVLEEVLSRGMLEVLPLTHIRGRS
FT                   LHDSFVIVDEAQSLERNVLLTVLSRLGTGSRVVLTHDIAQRDNLRVGRHDGVAAVIEKL
FT                   KGHPLFAHITLLRSERSPIAALVTEMLEEITGPR"
FT   misc_feature    189948..189971
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             190598..191473
FT                   /transl_table=11
FT                   /locus_tag="Rv1096"
FT                   /product="POSSIBLE GLYCOSYL HYDROLASE"
FT                   /function="PROBABLY INVOLVED IN CARBOHYDRATE DEGRADATION.
FT                   May Hydrolyse the glycosidic bond between two or more
FT                   carbohydrates or between a carbohydrate and a
FT                   non-carbohydrate moiety."
FT                   /EC_number="3.-.-.-"
FT                   /note="Rv1096, (MTV017.49), len: 291 aa. Possible glycosyl
FT                   hydrolase (EC 3.-.-.-), possibly deacetylase or esterase.
FT                   Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae
FT                   (291 aa) (81.3% identity in 289 aa overlap). Similar at the
FT                   C-terminus to enzymes involved in carbohydrate degradation
FT                   including Z99110|BSUB0007_92 endo-1,4-beta-xylanase homolog
FT                   yjeA from Bacillus subtilis (467 aa), FASTA scores: opt:
FT                   418, E(): 2.6e-17, (38.6% identity in 184 aa overlap);
FT                   M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces
FT                   lividans (335 aa), FASTA scores: opt: 371, E(): 1.1e-14,
FT                   (31.6% identity in 237 aa overlap); NP_345933.1|NC_003028
FT                   peptidoglycan N-acetylglucosamine deacetylase A from
FT                   Streptococcus pneumoniae (463 aa); etc. Has possible
FT                   N-terminal signal sequence with TMhelix at aa 13-31.
FT                   TBparse score is 0.905."
FT                   /db_xref="GOA:O53444"
FT                   /db_xref="InterPro:IPR002509"
FT                   /db_xref="UniProtKB/TrEMBL:O53444"
FT                   /protein_id="CAA17212.1"
FT                   /translation="MPKRPDNQTWRYWRTVTGVVVAGAVLVVGGLSGRVTRAENLSCSV
FT                   IKCVALTFDDGPGPYTDRLLHILTDNDAKATFFLIGNKVAANPAGARRIADAGMEIGSH
FT                   TWEHPNMTTIPPEDIPGQFSRANDVIAAATGRTPTLYRPAGGLSNDAVRQAAAKVGQAE
FT                   ILWDVIPFDWINDSNTAATRHMLMTQIKPGSVVLFHDTYSSTVDVVYQFIPVLKANGYR
FT                   LVTVSELLGPRAPGSSYGSRENGPPVNELRDIPASEIPPLPNTSSPKPMPNFPITDIAG
FT                   QNSGGPNNGA"
FT   CDS             complement(191476..192357)
FT                   /transl_table=11
FT                   /locus_tag="Rv1097c"
FT                   /product="PROBABLE MEMBRANE GLYCINE AND PROLINE RICH
FT                   PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1097c, (MTV017.50c), len: 293 aa. Probable
FT                   membrane Gly-, Pro-rich protein, similar to Mycobacterium
FT                   tuberculosis Rv2507|MTCY07A7. 13|Z95556 (273 aa), FASTA
FT                   scores: opt: 219, E(): 0.023, (30.5% identity in 266 aa
FT                   overlap); and Rv2507. Contains potential membrane spanning
FT                   region (aa ~68-92). TBparse score is 0.912."
FT                   /db_xref="UniProtKB/TrEMBL:O53445"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17213.1"
FT                   /translation="MTVPPAGPYGNYPYGPNTYGQDPYWGGQPQGGSYPPAYPPQQYPP
FT                   GWPAGPYPPGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPATS
FT                   APTSQPFSQQTATGCTPNVSGGVQPIGDSISAGKLSFPTSAAPGWSAFSDDQNPNLIDA
FT                   VGVGHEVAGADQWMMQAEVAITNFVTTMDVAAQASKLMQCVADGPGYAGSSPTLGPTKT
FT                   SSITVDGVRAARVDADITIADSSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSRATV
FT                   ERVIEALKVNKS"
FT   CDS             complement(192354..193778)
FT                   /transl_table=11
FT                   /gene="fum"
FT                   /locus_tag="Rv1098c"
FT                   /product="PROBABLE FUMARASE FUM (Fumarate hydratase)"
FT                   /function="Involved in the tricarboxylic acid cycle.
FT                   Catalyzes the reversible hydration of fumarate to L-malate
FT                   [CATALYTIC ACTIVITY: (S)-malate = fumarate + H2O]"
FT                   /EC_number="4.2.1.2"
FT                   /note="Rv1098c, (MTV017.51c), len: 474 aa. Probable fum,
FT                   fumarase (EC 4.2.1.2). Equivalent to AL049491|MLCB1222_11
FT                   Mycobacterium leprae (474 aa) (89.5 % identity in 467 aa
FT                   overlap). Similar to many e.g. P14408|FUMH_RAT FUMARATE
FT                   HYDRATASE, MITOCHONDRIAL PRECURSOR from Rattus norvegicus
FT                   (507 aa), FASTA scores: opt: 1427, E(): 0, (52.3% identity
FT                   in 461 aa overlap); and P05042|FUMC_ECOLI Fumarate
FT                   hydratase class II from Escherichia coli (467 aa), FASTA
FT                   scores: opt: 1355, E(): 0, (50.2% identity in 444 aa
FT                   overlap). Contains PS00163 Fumarate lyases signature.
FT                   TBparse score is 0.886."
FT                   /db_xref="GOA:O53446"
FT                   /db_xref="HSSP:1KQ7"
FT                   /db_xref="InterPro:IPR000362"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53446"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17214.1"
FT                   /translation="MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
FT                   LERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGS
FT                   GTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPAL
FT                   QQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLG
FT                   ELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGAL
FT                   RTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQV
FT                   IGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLR
FT                   RLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRL
FT                   DVLAMAKAEQLDSDRL"
FT   misc_feature    complement(192801..192830)
FT                   /note="PS00163 Fumarate lyases signature"
FT   CDS             complement(193809..194795)
FT                   /transl_table=11
FT                   /locus_tag="Rv1099c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1099c, (MTV017.52c), len: 328 aa. Conserved
FT                   hypothetical protein, highly similar to P44811|GLPX_HAEIN
FT                   GLPX PROTEIN HOMOLOG (believed to be involved in glycerol
FT                   metabolism) (333 aa), FASTA scores: opt: 763, E():0, (46.2%
FT                   identity in 327 aa overlap); and Q03224|YWJI_BACSU
FT                   hypothetical protein from Bacillus subtilis (321aa ), FASTA
FT                   scores: opt: 1092, E(): 0, (52.1% identity in 313 aa
FT                   overlap). Equivalent to AL049491|MLCB1222_10 Mycobacterium
FT                   leprae (355 aa), (93.0% identity in 328 aa overlap).
FT                   TBparse score is 0.878."
FT                   /db_xref="GOA:O53447"
FT                   /db_xref="HSSP:1NI9"
FT                   /db_xref="InterPro:IPR004464"
FT                   /db_xref="UniProtKB/TrEMBL:O53447"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17215.1"
FT                   /translation="MELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRG
FT                   VVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGTTLMSKGMTNAISVLAVADRG
FT                   TMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKDLSVRDMTVCILDRPRHA
FT                   QLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGA
FT                   IQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPG
FT                   GCTTHSIVMRSKSGTVRMIEAYHRLSKLNEYSAIDFTGDSSAVYPLP"
FT   CDS             194896..195597
FT                   /transl_table=11
FT                   /locus_tag="Rv1100"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1100, (MTV017.53), len: 233 aa. Conserved
FT                   hypothetical protein, slightly similar to
FT                   Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium
FT                   tuberculosis (156 aa), FASTA scores: opt: 122, E(): 6.9,
FT                   (27.4% identity in 135 aa overlap). Equivalent to
FT                   AL049491|MLCB1222_9 Mycobacterium leprae (257 aa) (63.8%
FT                   identity in 257 aa overlap). TBparse score is 0.914."
FT                   /db_xref="UniProtKB/TrEMBL:O53448"
FT                   /protein_id="CAA17216.1"
FT                   /translation="MVGDCPRSRTVRWSWDTGHVTAEPQPTPRPAKPRLLQDGRDMFWS
FT                   LAPLVVGCILLAGLVGMCSFQLGGTKRGPIPSYDAAQALRADAKTLGFPIRLPQLPGGW
FT                   TPNSGGRGGIENGRADPATGQRRNAATSIVGFISPTGRYLSLTQSNADEDKLVGSIHPS
FT                   MYPTGTVDVGGTRWVVYEGSDENGAVEPVWTTRLTGPGGATQLAITGAGSIDQFRTLAS
FT                   ATQSQPPLPAR"
FT   CDS             complement(195604..196761)
FT                   /transl_table=11
FT                   /locus_tag="Rv1101c"
FT                   /product="CONSERVED MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1101c, (MTV017.54c), len: 385 aa. Conserved
FT                   membrane protein, shows some similarity to other bacterial
FT                   proteins e.g. P77406|PERM_ECOLI PUTATIVE PERMEASE PERM from
FT                   Escherichia coli (353 aa), FASTA scores: opt: 287, E():
FT                   8.8e-12, (24.9% identity in 349 aa overlap). TBparse score
FT                   is 0.886."
FT                   /db_xref="GOA:O53449"
FT                   /db_xref="InterPro:IPR002549"
FT                   /db_xref="UniProtKB/Swiss-Prot:O53449"
FT                   /protein_id="CAA17217.1"
FT                   /translation="MNTEFTLTQKRALAILTLIALLFGAYFLRNYFVLIVVAAVGAYLF
FT                   TPLFKWFTKRFNTGLSAACTLLSALAAVVVPVGALVGLAIVQIARMVDSVADWVRTTDL
FT                   STLGDKILQFVNGLFDRVPFLHITVTADALRKAMISVAQNVGEWLLHFLRDAAGSLAGV
FT                   ITSAIIFVYVFVALLVNREKLRTLIGQLNPLGEDVTDLYLQKMGSMVRGTVNGQFVIAA
FT                   CQGVAGAASIYIAGFHHGFFIFAIVLTALSIIPLGGGIVTIPFGIGMIFYGNIAGGIFV
FT                   LLWHLLVVTNIDNVLRPILVPRDARLNSALMLLSVFAGITMFGPWGIIIGPVLMILIVT
FT                   TIDVYLAVYKGVELEQFEAPPVRRRWLPRRGPATSRNAPPPSTAE"
FT   CDS             complement(196873..197184)
FT                   /transl_table=11
FT                   /locus_tag="Rv1102c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1102c, (MTV017.55c), len: 103 aa. Conserved
FT                   hypothetical protein, similar to Mycobacterium tuberculosis
FT                   hypothetical protens e.g. Rv1942c|MTCY9F9_22 (109 aa),
FT                   FASTA scores: opt: 158, E(): 3.6e-05, (33.3% identity in 93
FT                   aa overlap); Rv0659c|MTCI376_17 (102aa), opt: 140, E():
FT                   0.00072, (40.6% identity in 69aa overlap); and Rv1495.
FT                   TBparse score is 0.924."
FT                   /db_xref="GOA:O53450"
FT                   /db_xref="InterPro:IPR011067"
FT                   /db_xref="UniProtKB/TrEMBL:O53450"
FT                   /protein_id="CAA17218.1"
FT                   /translation="MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATE
FT                   VPVDAVNGLNQPSVVSCDNTQTIPVCDLGRQIGYLLASQEPALAEAIGNAFDLDWVVA"
FT   CDS             complement(197184..197504)
FT                   /transl_table=11
FT                   /locus_tag="Rv1103c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1103c, (MTV017.56c), len: 106 aa. Conserved
FT                   hypothetical protein, similar to part of Mycobacterium
FT                   tuberculosis hypothetical protein Rv2472|AL021246|MTV008_27
FT                   Mycobacterium tuberculosis (97 aa), FASTA score: opt: 135,
FT                   E(): 0.0091, (45.8% identity in 72 aa overlap). TBparse
FT                   score is 0.916."
FT                   /db_xref="UniProtKB/TrEMBL:O53451"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17219.1"
FT                   /translation="MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFI
FT                   DDEVRGQHARSRAAVVLRALERERRRRLAERDAEILATNTSATGDLDTLAGHCARTALD
FT                   ID"
FT   CDS             197514..198203
FT                   /transl_table=11
FT                   /locus_tag="Rv1104"
FT                   /product="POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)"
FT                   /function="IN COMBINATION WITH MTV017.58|Rv1105 CATALYZES
FT                   HYDROLYSIS OF SEVERAL BETA-LACTAM ANTIBIOTIC PNB ESTERS TO
FT                   THE CORRESPONDING FREE ACID AND PNB ALCOHOL"
FT                   /EC_number="3.1.1.-"
FT                   /note="Rv1104, (MTV017.57), len: 229 aa. Possible
FT                   para-nitrobenzyl esterase (fragment; possibly first part)
FT                   (EC 3.1.1.-). Similar to the N-terminal domain of many e.g.
FT                   P37967|PNBA_BACSU Bacillus subtilis (489 aa), FASTA scores:
FT                   opt: 715, E(): 0, (53.4% identity in 191 aa overlap). Gene
FT                   may be inactivated as a frameshift is required to obtain a
FT                   product continuing in MTV017.58|Rv1105. TBparse score is
FT                   0.934."
FT                   /db_xref="GOA:O53452"
FT                   /db_xref="HSSP:1QE3"
FT                   /db_xref="InterPro:IPR002018"
FT                   /db_xref="UniProtKB/TrEMBL:O53452"
FT                   /protein_id="CAA17220.1"
FT                   /translation="MVVDSCVAESRYGPVRGADDGRVKVWKGIRYAAPPLGDLRFRTPE
FT                   PPERWTEVADATTFGPACPQPAIPNMPLDLGASQSEDCWSLNIWAPADTEPGDGKPVMV
FT                   WLHGGAYILGSGSQPLYNGRRLAASGDVVVVTVNYRLGALGFLDLSSFNTSRRRFDSNI
FT                   GLRDVLAVLRWVADNIAVFGGDPEKVTLFGESARESSRPCSPPRRPRVCSRRRSPRAHR
FT                   RHRSTTR"
FT   CDS             198524..199039
FT                   /transl_table=11
FT                   /locus_tag="Rv1105"
FT                   /product="POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)"
FT                   /function="IN COMBINATION WITH MTV017.57|Rv1104 CATALYZES
FT                   HYDROLYSIS OF SEVERAL BETA-LACTAM ANTIBIOTIC PNB ESTERS TO
FT                   THE CORRESPONDING FREE ACID AND PNB ALCOHOL"
FT                   /EC_number="3.1.1.-"
FT                   /note="Rv1105, (MTV017.58), len: 171 aa. Possible
FT                   para-nitrobenzyl esterase (fragment; possibly second part)
FT                   (EC 3.1.1.-). Similar to C-terminal domain of many e.g.
FT                   P71048 PARA-NITROBENZYL ESTERASE from Bacillus subtilis
FT                   (489 aa), FASTA scores: opt: 248, E(): 2.7e-10, (32.3%
FT                   identity in 167 aa overlap). Gene may be inactivated as a
FT                   frameshift is required to obtain a product continuing from
FT                   MTV017.57|Rv1104. Start changed since first submission.
FT                   TBparse score is 0.936."
FT                   /db_xref="GOA:O53453"
FT                   /db_xref="HSSP:1QE3"
FT                   /db_xref="InterPro:IPR002018"
FT                   /db_xref="UniProtKB/TrEMBL:O53453"
FT                   /protein_id="CAA17221.2"
FT                   /translation="MFTQIAAEQPDLQVPTEEQIGSAYSRWRRKARSLSMATDVGFRMP
FT                   SVWLAEGHSGVAPVYLYRFDYSTPLLKLLLVRAAHATELPYVWGNLGGSQDPALKLGDA
FT                   KAAIAVSRRVRTRWINFATRGKPTGPDGEPDWPCYEEAHRACLIIGRRDAVVHDVDAHI
FT                   RATWGSKW"
FT   CDS             complement(199057..200169)
FT                   /transl_table=11
FT                   /locus_tag="Rv1106c"
FT                   /product="PROBABLE CHOLESTEROL DEHYDROGENASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM"
FT                   /EC_number="1.1.1.-"
FT                   /note="Rv1106c, (MTV017.59c), len: 370 aa. Probable
FT                   cholesterol dehydrogenase (EC 1.1.1.-). Equivalent to
FT                   AL049491|MLCB1222_7 Mycobacterium leprae (376 aa ) (75.5%
FT                   identity in 375 aa overlap). Highly similar to Q03704
FT                   NAD(P)-dependent cholesterol dehydrogenase from Nocardia
FT                   sp. (364 aa), FASTA scores: opt: 1789, E(): 0, (74.5%
FT                   identity in 361 aa overlap). Also similar to
FT                   U32426|MCU32426_1 3-beta-hydroxy-Delta5-steroid
FT                   dehydrogenase from Molluscum contagiosum virus (354 aa),
FT                   FASTA scores: opt: 432, E(): 1.7e-22, (34.6% identity in
FT                   347 aa overlap). Also similar to series of Mycobacterium
FT                   tuberculosis hypothetical proteins described as sugar
FT                   epimerases or dehydratases e.g. Rv3634c, Rv3784, Rv3464,
FT                   etc. TBparse score is 0.885. The transcription of this CDS
FT                   seems to be activated specifically in host granulomas (see
FT                   Ramakrishnan et al., 2000)."
FT                   /db_xref="GOA:O53454"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O53454"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17222.1"
FT                   /translation="MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFD
FT                   RAPSLLPAHPQLEVLQGDITDADVCAAAVDGIDTIFHTAAIIELMGGASVTDEYRQRSF
FT                   AVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGDETLPYTDRFNDLYTETKV
FT                   VAERFVLAQNGVDGMLTCAIRPSGIWGNGDQTMFRKLFESVLKGHVKVLVGRKSARLDN
FT                   SYVHNLIHGFILAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRIS
FT                   GPAVRWVMTGWQRLHFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTTQQA
FT                   LTECLPYYVSLFEQMKNEARAEKTAATVKP"
FT   CDS             complement(200179..200436)
FT                   /transl_table=11
FT                   /gene="xseB"
FT                   /locus_tag="Rv1107c"
FT                   /product="PROBABLE EXODEOXYRIBONUCLEASE VII (SMALL SUBUNIT)
FT                   XSEA (EXONUCLEASE VII SMALL SUBUNIT)"
FT                   /function="BIDIRECTIONALLY DEGRADES SINGLE-STRANDED DNA
FT                   INTO LARGE ACID-INSOLUBLE OLIGONUCLEOTIDES, WHICH ARE THEN
FT                   DEGRADED FURTHER INTO SMALL ACID-SOLUBLE OLIGONUCLEOTIDES
FT                   [CATALYTIC ACTIVITY: EXONUCLEOLYTIC CLEAVAGE IN EITHER 5'-
FT                   TO 3'- OR 3'- TO 5'-DIRECTION TO YIELD
FT                   5'-PHOSPHOMONONUCLEOTIDES.]"
FT                   /EC_number="3.1.11.6"
FT                   /note="Rv1107c, (MTV017.60c), len: 85 aa. Probable xseB,
FT                   exonuclease VII small subunit (EC 3.1.11.6) (see citation
FT                   below). Equivalent to AL049491|MLCB1222_6 Mycobacterium
FT                   leprae (87 aa) (77.9% identity in 68 aa overlap). Similar
FT                   to P43914|EX7S_HAEIN EXODEOXYRIBONUCLEASE SMALL SUBUNIT
FT                   from H. influenzae (84 aa), FASTA scores: opt: 126, E():
FT                   0.006, (37.3% identity in 67 aa overlap); and
FT                   P22938|EX7S_ECOLI EXODEOXYRIBONUCLEASE SMALL SUBUNIT from
FT                   Escherichia coli (79 aa), FASTA scores: opt: 125, E():
FT                   0.0067, (39.7% identity in 58 aa overlap). TBparse score is
FT                   0.912. BELONGS TO THE XSEB FAMILY."
FT                   /db_xref="GOA:P67456"
FT                   /db_xref="InterPro:IPR003761"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67456"
FT                   /protein_id="CAA17223.1"
FT                   /translation="MVCDPNGDDTGRTHATVPVSQLGYEACRDELMEVVRLLEQGGLDL
FT                   DASLRLWERGEQLAKRCEEHLAGARQRVSDVLAGDEAQNG"
FT   CDS             complement(200426..201673)
FT                   /transl_table=11
FT                   /gene="xseA"
FT                   /locus_tag="Rv1108c"
FT                   /product="PROBABLE EXODEOXYRIBONUCLEASE VII (LARGE SUBUNIT)
FT                   XSEA (EXONUCLEASE VII LARGE SUBUNIT)"
FT                   /function="BIDIRECTIONALLY DEGRADES SINGLE-STRANDED DNA
FT                   INTO LARGE ACID-INSOLUBLE OLIGONUCLEOTIDES, WHICH ARE THEN
FT                   DEGRADED FURTHER INTO SMALL ACID-SOLUBLE OLIGONUCLEOTIDES
FT                   [CATALYTIC ACTIVITY: EXONUCLEOLYTIC CLEAVAGE IN EITHER 5'-
FT                   TO 3'- OR 3'- TO 5'-DIRECTION TO YIELD
FT                   5'-PHOSPHOMONONUCLEOTIDES]"
FT                   /EC_number="3.1.11.6"
FT                   /note="Rv1108c, (MTV017.61c), len: 415 aa. Probable xseA,
FT                   exodeoxyribonuclease VII large subunit (EC 3.1.11.6) (see
FT                   Mizrahi & Andersen 1998). Equivalent to AL049491|MLCB1222_5
FT                   Mycobacterium leprae (428 aa) (81.5% identity in 411 aa
FT                   overlap). Similar to many e.g. P04994|EX7L_ECOLI
FT                   exodeoxyribonuclease large subunit from Escherichia coli
FT                   (456 aa), FASTA scores: opt: 581, E(): 1.6 e-30, (30.8%
FT                   identity in 425 aa overlap); also similar to the
FT                   exodeoxyribonuclease in Bacillus subtilis, H. influenzae
FT                   and H. pylori. TBparse score is 0.890. BELONGS TO THE XSEA
FT                   FAMILY."
FT                   /db_xref="GOA:P67447"
FT                   /db_xref="InterPro:IPR004365"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67447"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17224.1"
FT                   /translation="MTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAK
FT                   TVFMVLRDPAADMSLTVTCSRDLVLSAPVKLAEGVQVVVCGKPSFYTGRGTFSLRLSEI
FT                   RAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTTVAS
FT                   ARWPAARFAVRNVAVQGPNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDET
FT                   LCRAIAACRTPVVSAVGHEPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRR
FT                   RSAQALRNWVSREQRAVAQLRSRPVLADPMTMVSVRAEEVHRARSTLRRNLTLMVAAET
FT                   ERIGHLAARLATLGPAATLARGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRV
FT                   ADGALAAVSEGQTNGL"
FT   CDS             complement(201670..202308)
FT                   /transl_table=11
FT                   /locus_tag="Rv1109c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1109c, (MTV017.62c), len: 212 aa. Conserved
FT                   hypothetical protein. Equivalent to AL049491|MLCB1222_4
FT                   hypothetical protein from Mycobacterium leprae (205 aa)
FT                   (68.1% identity in 213 aa overlap). TBparse score is
FT                   0.905."
FT                   /db_xref="UniProtKB/TrEMBL:O53457"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17225.1"
FT                   /translation="MATAPYGVRLLVGAATVAVEETMKLPRTILMYPMTLASQAAHVVM
FT                   RFQQGLAELVIKGDNTLETLFPPKDEKPEWATFDEDLPDALEGTSIPLLGLSDASEAKN
FT                   DDRRSDGRFALYSVSDTPETTTASRSADRSTNPKTAKHPKSAAKPTVPTPAVAAELDYP
FT                   ALTLAQLRARLHTLDVPELEALLAYEQATKARAPFQTLLANRITRATAK"
FT   CDS             202398..203405
FT                   /transl_table=11
FT                   /gene="lytB2"
FT                   /locus_tag="Rv1110"
FT                   /product="PROBABLE LYTB-RELATED PROTEIN LYTB2"
FT                   /function="NOT KNOWN. IN OTHER ORGANISMS, LYTB PRODUCT IS
FT                   INVOLVED IN PENICILLIN TOLERANCE AND CONTROL OF THE
FT                   STRINGENT RESPONSE."
FT                   /note="Rv1110, (MTV017.63), len: 335 aa. Probable lytB2,
FT                   LytB-related protein, equivalent to AL049491|MLCB1222_3
FT                   from Mycobacterium leprae (335 aa), FASTA score: (82.9%
FT                   identity in 333 aa overlap). Also similar to LytB proteins
FT                   from many bacteria (appears to have N-terminal extension)
FT                   e.g. P22565|LYTB_ECOLI|B0029|Z0034|ECS0032 LYTB PROTEIN
FT                   from Escherichia coli strains K12 and O157:H7 (316 aa),
FT                   FASTA scores: opt: 1041, E():0, (52.4% identity in 309 aa
FT                   overlap); etc. Also very similar to another LytB-related
FT                   protein from Mycobacterium tuberculosis:
FT                   LytB1|Rv3382c|MTV004.40c (329 aa), FASTA scores: opt: 975,
FT                   E(): 0, (51.3% identity in 312 aa overlap). BELONGS TO THE
FT                   LYTB FAMILY. TBparse score is 0.899."
FT                   /db_xref="GOA:P0A5I0"
FT                   /db_xref="InterPro:IPR003451"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5I0"
FT                   /protein_id="CAE55361.1"
FT                   /translation="MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAVE
FT                   TVERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVFSAHGVAPT
FT                   VHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVVGTAGEAPDHV
FT                   QLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKLQDPPSDDICYAT
FT                   QNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDG
FT                   VTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR"
FT   CDS             complement(203422..204405)
FT                   /transl_table=11
FT                   /locus_tag="Rv1111c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1111c, (MTV017.64c), len: 327 aa. Conserved
FT                   hypothetical protein, N-terminal domain is hydrophobic,
FT                   C-terminal half is very rich in Arg. Equivalent to
FT                   AL049491|MLCB1222_2 hypothetical protein from Mycobacterium
FT                   leprae (379 aa) (46.0% identity in 374 aa overlap). Start
FT                   changed since first submission. TBparse score is 0.934."
FT                   /db_xref="UniProtKB/TrEMBL:O86351"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAA17227.2"
FT                   /translation="MSAQRARSAVQASHRSIHPHIPGVPWWAAILIAVTATAIGYAIDA
FT                   GSGHKALTLVFTGCYIAGCVGAVLAVRQSDLFTALVQPPLILFCAVPGAYWLFHGGTIG
FT                   KFKDLLINCGYSLIERFPLMLGTAAGVLLIGLVRWYLGTALFDSIARKLSSLMTGDSDD
FT                   DGGRRSAQRPARTRSRHARPPSEDNREPIAERRSRRRPRPQNDPHPRRNAHERPAPRSS
FT                   RFDSYRSYQPSEPSGPAEPVNRYERRGARYQPYARYEPTYEPQRRRARPSEPTNPTHHP
FT                   ISQVRYRGSATRDARRDNYREEQRFDRRDRSRAPRRPPAESWEYDV"
FT   CDS             204468..205541
FT                   /transl_table=11
FT                   /locus_tag="Rv1112"
FT                   /product="Probable GTP binding protein"
FT                   /function="UNKNOWN"
FT                   /note="Rv1112, (MTCY22G8.01-MTV017.65), len: 357 aa.
FT                   Probable GTP binding protein, similar to YCHF_HAEIN|P44681
FT                   probable gtp-binding protein (362 aa), FASTA scores: opt:
FT                   1189, E(): 0, (52.7% identity in 357 aa overlap).
FT                   Equivalent to AL049491|MLCB1222_1 hypothetical protein from
FT                   Mycobacterium leprae (356 aa) (85.9% identity in 354 aa
FT                   overlap0. Contains PS00017 ATP/GTP-binding site motif A
FT                   (P-loop)."
FT                   /db_xref="GOA:O53459"
FT                   /db_xref="HSSP:1JAL"
FT                   /db_xref="InterPro:IPR013029"
FT                   /db_xref="UniProtKB/TrEMBL:O53459"
FT                   /protein_id="CAA17228.1"
FT                   /translation="MSLSLGIVGLPNVGKSTLFNALTRNNVVAANYPFATIEPNEGVVS
FT                   LPDPRLDKLAELFGSQRVVPAPVTFVDIAGLVKGASEGAGLGNKFLAHIRECDAICQVV
FT                   RVFVDDDVTHVTGRVDPQSDIEVVETELILADLQTLERATGRLEKEARTNKARKPVYDA
FT                   ALRAQQVLDAGKTLFAAGVDAAALRELNLLTTKPFLYVFNADEAVLTDPARVGELRALV
FT                   APADAVFLDAAIESELTELDDESAAELLESIGQSERGLDALARAGFHTLKLQTFLTAGP
FT                   KEARAWTIHQGDTAPKAAGVIHSDFEKGFIKAEIVSYDDLVAAGSMAAAKAAGKVRIEG
FT                   KDYVMADGDVVEFRFNV"
FT   misc_feature    204492..204515
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT   CDS             205629..205826
FT                   /transl_table=11
FT                   /locus_tag="Rv1113"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1113, (MTCY22G8.02), len: 65 aa. Conserved
FT                   hypothetical protein, similar to Mycobacterium tuberculosis
FT                   hypothetical protein Rv2758c|AL00896 7|MTV002.23 (88 aa)
FT                   FASTA scores: opt: 97, E(): 0.86, (33.3% identity in 69 aa
FT                   overlap). Part of family including Rv2871, Rv1241, Rv2132,
FT                   Rv3321c, etc."
FT                   /db_xref="InterPro:IPR019239"
FT                   /db_xref="UniProtKB/TrEMBL:O06565"
FT                   /protein_id="CAB09045.1"
FT                   /translation="MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLA
FT                   ALGGTDPQATAAPRRRTSPR"
FT   CDS             205823..206197
FT                   /transl_table=11
FT                   /locus_tag="Rv1114"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1114, (MTCY22G8.03), len: 124 aa. Conserved
FT                   hypothetical protein, slight similarity to Mycobacterium
FT                   tuberculosis hypothetical proteins MTCY159.08c (33.0%
FT                   identity in 115 aa overlap); Rv1561 and Rv2010."
FT                   /db_xref="InterPro:IPR002716"
FT                   /db_xref="UniProtKB/TrEMBL:O06566"
FT                   /protein_id="CAB09046.1"
FT                   /translation="MILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIK
FT                   QRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGRGLGAVDANLLGSVALVGGARLWTR
FT                   DKRLKAACAESGVALAEEVS"
FT   CDS             206400..207098
FT                   /transl_table=11
FT                   /locus_tag="Rv1115"
FT                   /product="POSSIBLE EXPORTED PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1115, (MTCY22G8.04), len: 232 aa. Possible
FT                   exported protein, contains possible N-terminal signal
FT                   sequence."
FT                   /db_xref="UniProtKB/TrEMBL:O06567"
FT                   /protein_id="CAB09047.1"
FT                   /translation="MISTTRIDFLWILSVAFASMIALATLLTLINQVVGTPYIPGGDSP
FT                   AGTDCSELASWVSNAATARPVFGDRFNTGNEEAALAARGFQQGTAPNALVIGWNGHHTA
FT                   VTLPDGTPVSSGEGGGVRVGGGGAYQPKFTHHMYLPMDVDAGEDQPPAPDEPVTAVDDV
FT                   EPEMPAPCPTQRPPVTPRHNLCNKLRTMPGALSAALAAAAPVWPAPISGCRGFSTSLLA
FT                   KRNHPVIVGK"
FT   CDS             207216..207401
FT                   /transl_table=11
FT                   /locus_tag="Rv1116"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1116, (MTCY22G8.05), len: 61 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O06568"
FT                   /protein_id="CAB09048.1"
FT                   /translation="MCSRMADEPRLEAGAHPFEEGRDKAPELRATQMDHVRFTEGRRER
FT                   NRDRLERSQQFRQPGR"
FT   CDS             complement(207328..207603)
FT                   /transl_table=11
FT                   /locus_tag="Rv1116A"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT)"
FT                   /function="UNKNOWN"
FT                   /note="Rv1116A, len: 91 aa. Conserved hypothetical protein
FT                   (possibly gene fragment), similar to C-terminal part of
FT                   Rv1646|Z85982_9 from Mycobacterium tuberculosis (310 aa),
FT                   FASTA scores: opt: 301, E(): 9.3e-13, (68.05% identity in
FT                   72 aa overlap). Also overlaps gene on other strand, Rv1116,
FT                   at 3'-end."
FT                   /db_xref="UniProtKB/TrEMBL:Q8VK68"
FT                   /protein_id="CAE55362.1"
FT                   /translation="MGALGTVRGLQDSNTAFVGALHSGNLLGATGAVLQAPGNAVNGFL
FT                   FGQTSISQSIDVSPEYGYELVAVSDPVGGTAGSARAGHGYVHADLR"
FT   CDS             207846..208169
FT                   /transl_table=11
FT                   /locus_tag="Rv1117"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1117, (MTCY22G8.06), len: 107 aa. Conserved
FT                   hypothetical protein, some similarity to P94425|D50453
FT                   hypothetical protein from Bacillus subtilis (95 aa), fasta
FT                   scores: opt: 128, E(): 5.1e-06, (28.3% identity in 92 aa
FT                   overlap); and AL117322|SCF1.02 Streptomyces coelicolor (109
FT                   aa), FASTA scores: opt: 437, E(): 1.6e-25, (57.5% identity
FT                   in 106 aa overlap)."
FT                   /db_xref="GOA:O06569"
FT                   /db_xref="InterPro:IPR007138"
FT                   /db_xref="UniProtKB/TrEMBL:O06569"
FT                   /protein_id="CAB09049.1"
FT                   /translation="MIFIVVKFETKPEWTERWPDLVASFTAATRAEEGNLWFEWSRSLD
FT                   DPAEYVLVESFRDGEAGGVHVNSDHFRQAMRELPKALASTPKIISQTIDATGWSAMGEM
FT                   TVG"
FT   CDS             complement(208184..209044)
FT                   /transl_table=11
FT                   /locus_tag="Rv1118c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1118c, (MTCY22G8.07c), len: 286 aa. Conserved
FT                   hypothetical protein, similar to pseudogene ML0942 in
FT                   Mycobacterium leprae."
FT                   /db_xref="UniProtKB/TrEMBL:O06570"
FT                   /protein_id="CAB09050.1"
FT                   /translation="MQSGPHLVGRVGTSFPLIARHQGATRDDAGDTGQPDPLPHVAHPD
FT                   RLYPPMVHGVDPSTLALDRALNETRTGDLWLFRGRSRPDRAIQTLTNAPVNHVGMTVAI
FT                   DDLPPLIWHAELGDKLLDVWTGTNHRGVQLNDARQVVQQWAGRYRQRCWLRQLTPHANR
FT                   DQEDKLLRVIARMNGTPFPTTARLTGRWLRGRLPTLNDWLRGIPVLDRKVREQTQRRKQ
FT                   QQRTMGLATAYCAETVAITYEEMGLLVTDKDAHWFDPGKFWSGDSLPLAPGYRLGHEIA
FT                   VDVGG"
FT   CDS             complement(209077..209226)
FT                   /transl_table=11
FT                   /locus_tag="Rv1119c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1119c, (MTCY22G8.08c), len: 49 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O06571"
FT                   /protein_id="CAB09051.1"
FT                   /translation="MTARVAGQAVGGQILVGEPVHDAVSDCADIRFGSYRLFSLDAAPG
FT                   PDLD"
FT   CDS             complement(209223..209717)
FT                   /transl_table=11
FT                   /locus_tag="Rv1120c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1120c, (MTCY22G8.09c), len: 164 aa. Conserved
FT                   hypothetical protein, some similarity at C-terminus to
FT                   Mycobacterium tuberculosis hypothetical proteins e.g.
FT                   Rv1890c|MTCY180.28 (462 aa), FASTA scores: opt: 187, E():
FT                   2.2e-05, (36.6% identity in 93 aa overlap) and
FT                   Rv2488c|YZ19_MYCTU|Q10551 (285 aa), FASTA scores: opt: 156,
FT                   E(): 0.00074, (32.7% identity in 107 aa overlap)."
FT                   /db_xref="GOA:O06572"
FT                   /db_xref="HSSP:1FX2"
FT                   /db_xref="InterPro:IPR001054"
FT                   /db_xref="UniProtKB/TrEMBL:O06572"
FT                   /protein_id="CAB09052.1"
FT                   /translation="MLSGGREAVKTVWQTANLVRKEGFGAAVRSSIEDPADWAEVERPD
FT                   LARVTPDGRVVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMVTSQG
FT                   DGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWGARCGTVTICSAATS
FT                   Q"
FT   CDS             209920..211320
FT                   /transl_table=11
FT                   /gene="zwf1"
FT                   /locus_tag="Rv1121"
FT                   /standard_name="zwf"
FT                   /product="PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF1
FT                   (G6PD)"
FT                   /function="INVOLVED IN PENTOSE PHOSPHATE PATHWAY (FIRST
FT                   STEP) [CATALYTIC ACTIVITY : D-GLUCOSE 6-PHOSPHATE + NADP(+)
FT                   = D-GLUCONO-1,5-LACTONE 6-PHOSPHATE + NADPH.]"
FT                   /EC_number="1.1.1.49"
FT                   /note="Rv1121, (MTCY22G8.10), len 466 aa. Probable zwf1,
FT                   glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), highly
FT                   similar to many e.g. G6PD_E COLI|P22992 Escherichia coli
FT                   (491 aa), FASTA scores: opt: 642, E(): 0, (35.8% identity
FT                   in 478 aa overlap). Mycobacterium tuberculosis has two
FT                   genes for ZWF, this one is highly divergent. BELONGS TO THE
FT                   GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY. Note that
FT                   previously known as zwf."
FT                   /db_xref="GOA:P0A586"
FT                   /db_xref="HSSP:1QKI"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A586"
FT                   /protein_id="CAE55363.1"
FT                   /translation="MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILG
FT                   VASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGS
FT                   ACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAVLGE
FT                   DQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDA
FT                   VGALRDVVQNHLLQVLALVTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGY
FT                   TEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAF
FT                   LPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLY
FT                   AGLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSP
FT                   WLPRGTDA"
FT   CDS             211342..212364
FT                   /transl_table=11
FT                   /gene="gnd2"
FT                   /locus_tag="Rv1122"
FT                   /product="PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE,
FT                   DECARBOXYLATING GND2"
FT                   /function="INVOLVED IN HEXOSE MONOPHOSPHATE SHUNT (PENTOSE
FT                   PHOSPHATE PATHWAY). [CATALYTIC ACTIVITY:
FT                   6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate +
FT                   CO2 + NADPH]"
FT                   /EC_number="1.1.1.44"
FT                   /note="Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,
FT                   6-phosphogluconate dehydrogenase, decarboxylating (EC
FT                   1.1.1.44), highly similar to Q53917 6-PHOSPHOGLUCONATE
FT                   DEHYDROGENASE from Streptomyces coelicolor (291 aa), fasta
FT                   scores: opt: 431, E(): 2.2e-20, (44.5% identity in 335 aa
FT                   overlap). Also similar to Rv1844c|MTCY359.29|gnd1 PROBABLE
FT                   6-PHOSPHOGLUCONATE DEHYDROGENASE from Mycobacterium
FT                   tuberculosis (485 aa), FASTA score: (33.0% identity in 351
FT                   aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most
FT                   similar to gnd's from Gram negative organisms, while gnd2
FT                   is most similar to gnd's from Gram positive organisms.
FT                   BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY."
FT                   /db_xref="GOA:O06574"
FT                   /db_xref="HSSP:2PGD"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:O06574"
FT                   /protein_id="CAB09054.1"
FT                   /translation="MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRT
FT                   TGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLR
FT                   HEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRT
FT                   PGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQH
FT                   GDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVS
FT                   DSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFANKALSAMRKQFGGHAEKPAN
FT                   "
FT   CDS             complement(212357..213265)
FT                   /transl_table=11
FT                   /gene="bpoB"
FT                   /locus_tag="Rv1123c"
FT                   /product="POSSIBLE PEROXIDASE BPOB (NON-HAEM PEROXIDASE)"
FT                   /function="SUPPOSED INVOLVED IN DETOXIFICATION REACTIONS."
FT                   /EC_number="1.11.1.-"
FT                   /note="Rv1123c, (MTCY22G8.12c), len: 302 aa. Possible bpoB,
FT                   peroxidase (non-haem peroxidase) (EC 1.11.1.-), with some
FT                   similarity to a range of enzymes from several organisms
FT                   including: DEH1_MORSP|Q01398 haloacetate dehalogenase (EC
FT                   3.8.1.3) from Moraxella sp. (294 aa), FASTA scores: opt:
FT                   201, E(): 2.1e-06, (35.8% identity in 134 aa overlap); and
FT                   BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 (EC
FT                   1.11.1.-) from Streptomyces aureofaciens (274 aa), FASTA
FT                   scores: opt: 187, E(): 1.6e-05, (23.1% identity in 281 aa
FT                   overlap). Similar to several other Mycobacterium
FT                   tuberculosis proteins, probable epoxide hydrolases and
FT                   non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3473c,
FT                   Rv3171c, etc. Contains PS00216 Sugar transport proteins
FT                   signature 1."
FT                   /db_xref="GOA:O06575"
FT                   /db_xref="InterPro:IPR000073"
FT                   /db_xref="UniProtKB/TrEMBL:O06575"
FT                   /protein_id="CAB09055.1"
FT                   /translation="MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAA
FT                   AADRPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDRAPGADYAVETPT
FT                   TDVLHVVEAIGRRVVVVEASMGGLTGILVAERAGPQTVNGLVLVDVVPRYEKEGNARIR
FT                   DFMLGNIDGFGSLEEAADAVAEYLPHRDKPRSPEGLKRNLRLRDGRWHWHWDPAMMTAP
FT                   GHDPQLRTENFERAAMGLTIPVLLIRGKLSDVVSSDGARDFLAKVPNAEFVELSNAGRT
FT                   AAGDDNDAFTDVVVDFVRRLS"
FT   misc_feature    complement(212894..212947)
FT                   /note="PS00216 Sugar transport proteins signature 1"
FT   CDS             213340..214290
FT                   /transl_table=11
FT                   /gene="ephC"
FT                   /locus_tag="Rv1124"
FT                   /product="PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE
FT                   HYDRATASE)"
FT                   /function="THOUGHT TO BE INVOLVED IN DETOXIFICATION
FT                   REACTIONS FOLLOWING OXIDATIVE DAMAGE TO LIPIDS [CATALYTIC
FT                   ACTIVITY: AN EPOXIDE + H(2)O = A GLYCOL]."
FT                   /EC_number="3.3.2.3"
FT                   /note="Rv1124, (MTCY22G8.13), len: 316 aa. Probable ephC,
FT                   epoxide hydrolase (EC 3.3.2.3) (see citation below),
FT                   similar to Q42566 epoxide hydrolase from Arabidopsis
FT                   thaliana (321 aa), FASTA scores: opt: 298, E(): 8.2e-13,
FT                   (27.6% identity in 333 aa overlap). Similar to other M.
FT                   tuberculosis epoxide hydrolases and non-heme
FT                   bromoperoxidases e.g. Rv1938, Rv3617, Rv3670, Rv3473c,
FT                   etc."
FT                   /db_xref="GOA:O06576"
FT                   /db_xref="InterPro:IPR000639"
FT                   /db_xref="UniProtKB/TrEMBL:O06576"
FT                   /protein_id="CAB09056.1"
FT                   /translation="MRAGRGERESTWRTTMAEPHWIDVKGPNGDLKALTWGPAGAPVAL
FT                   CLHGFPDTAYGWRKVAPRLAESGWHVVAPFMRGYAPSSIPADGSYHVGALMHDALRVRS
FT                   AAGGTERDVIIGHDWGAIAATGLAAMPDSPFAKAVIMSVPPSAAFRPLGRVPERGRLLR
FT                   ELPHQLLRSWYILYFQLPWLPERSASWVVPLLWRRWSPGYHAEEDLRHVDAAIGTPEGR
FT                   RAALGPYRATMRNTRAPADYADLNRLWTEAPKLPVLYLHGHDDGCATSAFTHWTARVLP
FT                   AGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG"
FT   CDS             214295..215539
FT                   /transl_table=11
FT                   /locus_tag="Rv1125"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1125, (MTCY22G8.14), len: 414 aa. Conserved
FT                   hypothetical protein. Similar to AL133278|SCM11.13
FT                   hypothetical protein from Streptomyces coelicolor (446 aa),
FT                   FASTA scores: opt: 182, E(): 0.0005, (28.1% identity in 437
FT                   aa overlap)."
FT                   /db_xref="InterPro:IPR004255"
FT                   /db_xref="UniProtKB/TrEMBL:O06577"
FT                   /protein_id="CAB09057.1"
FT                   /translation="MAGHRMAAVDAQFYWMSAKVPNDQFLLYAFDGEPTDLERAVAQVY
FT                   RRARGCPGLGMRVQDRGALAYPQWVPTPVQRDQLVCHDLADRSWQGCLAAVVGLASKQL
FT                   DMRRMPWRLHVFTPVHDVPGVSGLGTVAVMQFAHALGDGARASAMAAWLFGRPAAVPEI
FT                   ARSRAGFLPWRAAHAARAHLRLVRDTNAGLVAPGVGSRPPLSTNARPEGVRAVRTLLRR
FT                   RSQLAGPTVTVTVLAAVSTGLLGLLGGDVDTLGAEVPMAKPGVPRSYNHFGNVVVGLYP
FT                   RLEPDERVRRIATDLANARRRFEHPAMLSADRAFAAVPAALLRWGVSQFDAEVRPVRVA
FT                   GNTVVSSVYRGAADLSFGDAPVVLTAGYPALSPAMGLTHGVHGIGDTVAISVHAAESAV
FT                   SDIDAYMRLLDAALQ"
FT   CDS             complement(215543..216148)
FT                   /transl_table=11
FT                   /locus_tag="Rv1126c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1126c, (MTCY22G8.15c), len: 201 aa. Conserved
FT                   hypothetical protein, similar in N-terminus to
FT                   O05567|MLCB33.17 hypothetical protein from Mycobacterium
FT                   leprae (141 aa), FASTA scores: opt: 332, E(): 1.4e-23,
FT                   (58.4% identity in 101 aa overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O06578"
FT                   /protein_id="CAB09058.1"
FT                   /translation="MSELTVLQAVRLKGRVITTDLAQTLGEDLADVAATVDRLTAAGLL
FT                   VDATPLRISPSGRMRLDDLLAEERNRADSTVLAAAYRDFRSVNADFKRLVTDWQLKGEK
FT                   PNTHDDAEYDAAVLSRLDGVHRRVGPIIGTVAMQLPRLSRYPVKLRAALDKVKAGDIAW
FT                   LTRPLIDSYHTVWFELHEELIQAVGLTRDEAAKSGDAQ"
FT   CDS             complement(216145..217617)
FT                   /transl_table=11
FT                   /gene="ppdK"
FT                   /locus_tag="Rv1127c"
FT                   /product="PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK"
FT                   /function="CATALYZES THE REVERSIBLE PHOSPHORYLATION OF
FT                   PYRUVATE AND PHOSPHATE [CATALYTIC ACTIVITY: ATP + pyruvate
FT                   + phosphate = AMP + phosphoenolpyruvate + diphosphate]"
FT                   /EC_number="2.7.9.1"
FT                   /note="Rv1127c, (MTCY22G8.16c), len: 490 aa. Probable ppdK,
FT                   Pyruvate, phosphate dikinase (EC 2.7.9.1). Equivalent (but
FT                   shorter) to Z94723|MLCB33_16 ppdK from Mycobacterium leprae
FT                   (601 aa) (71.8% identity in 478 aa overlap). Highly similar
FT                   to N-terminus of PODK_CLOSY|P22983 pyruvate, phosphate
FT                   dikinase from Clostridium symbiosum (873 aa), FASTA scores:
FT                   opt: 786, E(): 0, (37.4% identity in 514 aa overlap)."
FT                   /db_xref="GOA:O06579"
FT                   /db_xref="HSSP:1GGO"
FT                   /db_xref="InterPro:IPR002192"
FT                   /db_xref="UniProtKB/TrEMBL:O06579"
FT                   /protein_id="CAB09038.1"
FT                   /translation="MTRITRANGCPDGTLENAVVALDGGANYPREILGNKGHGIDMMRR
FT                   HHLPVPPAFCITTEVGVRYLAAPGSTIAAIWDDVLDRMSWLETETSCTFGRGPNPLLVS
FT                   VRSGATQSMPGMMDTILDVGMTDAVERVLARPGAADFAHDTRRRFTSMYRRIVGSAGPI
FT                   TDDPYAQLRASIEAVFASWNSPRAVAYRDHHGLDDQGGTAVVVQAMVFGNLTANSGAGV
FT                   LSSRNPITGANEPFGEWLPGGQGDDVVSGLVAVAPITALRDQQPAVYDQLMAAARSLER
FT                   MAGDVQEIEFTVEDSQLWLLQTRGAERSAQAAVRLALQLHHEGLIDDTETLRRVTPTHI
FT                   ETLLRPSLQTETRLAAPLLAKGLPACPGVVSGTAYTEVDEALDAADRGEPVILVRDHTR
FT                   PEDVMGMLAAQGIVTEVGGAASHAAVVSRELGRVAVVGCGPGVAAALAGKEITVDGYEG
FT                   EVRQGVLALSAWSESDTPELRELADIAQRISS"
FT   CDS             complement(217830..219185)
FT                   /transl_table=11
FT                   /locus_tag="Rv1128c"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1128c, (MTCY22G8.17c), len: 451 aa. Conserved
FT                   hypothetical protein, in REP13E12 degenerate repeat, highly
FT                   similar to several Mycobacterium tuberculosis proteins in
FT                   REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc."
FT                   /db_xref="InterPro:IPR003615"
FT                   /db_xref="UniProtKB/Swiss-Prot:O06580"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09039.1"
FT                   /translation="MCSTREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCETA
FT                   RRQLPSVEHTLINQIGEQSTEEELGGKLGLTLADRLRITRSEAKRRVAEAADLGQRRAL
FT                   TGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPSWVDLKTLEKAERDLAKQATQY
FT                   RPDQLAKLAARIMDCLNPDGDYTDEDRARRRGLTLGKQDVDGMSRLSGYVTPELRATIE
FT                   AVWAKLAAPGMCNPEQKAPCVNGAPSKEQARRDTRSCPQRNHDALNAELRSLLTSGNLG
FT                   QHNGLPASIIVTTTLKDLEAAAGAGLTGGGTILPISDVIRLARHANHYLAIFDRGKALA
FT                   LYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVTPYAQCRNTDVNDLTLGCG
FT                   GHHPLAERGWTTRKNAHGDTEWLPPPHLDHGQPRVNTFHHPEKLLADDEGDP"
FT   repeat_region   217834..219158
FT                   /label=REP-3
FT                   /rpt_type=DIRECT
FT                   /note="REP-3, len: 1325 bp. REP22G8, member of REP13E12
FT                   family."
FT   CDS             complement(219287..220747)
FT                   /transl_table=11
FT                   /locus_tag="Rv1129c"
FT                   /product="PROBABLE TRANSCRIPTIONAL REGULATOR PROTEIN"
FT                   /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT                   /note="Rv1129c, (MTCY22G8.18c), len: 486 aa. Possible
FT                   transcriptional regulator protein, similar to
FT                   Rv0465c|MTV038.09c Mycobacterium tuberculosis (474 aa),
FT                   FASTA scores: E(): 0, (47.4% identity in 468 aa overlap).
FT                   Helix turn helix motif present from aa 32-53."
FT                   /db_xref="GOA:O06581"
FT                   /db_xref="InterPro:IPR018653"
FT                   /db_xref="UniProtKB/TrEMBL:O06581"
FT                   /protein_id="CAB09040.1"
FT                   /translation="MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTS
FT                   YVNQLENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHAVSGA
FT                   QIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAETELPPARPMPFEEVRDFFY
FT                   DRNNYIHDLDMAAERMFTESGMRTGGLDIQLAELMRDRFGISVVIDDNLPDTAKRRYHP
FT                   DTKVLRVAHWLMPGQRAFQIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYF
FT                   AGAFLLPYREFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTD
FT                   KAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRSYFWVAKTTA
FT                   ADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPSTEVPIGAGCKICNRTSCAQR
FT                   AFPYLGGRVAVDENAGSSLPYSSTEQSV"
FT   CDS             220768..222348
FT                   /transl_table=11
FT                   /locus_tag="Rv1130"
FT                   /product="CONSERVED HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1130, (MTCY22G8.19), len: 526 aa. Conserved
FT                   hypothetical protein, some similarity to
FT                   AP000063|AP000063_192 hypothetical protein from Aeropyrum
FT                   pernix (479 aa), FASTA scores: opt: 717, E(): 0, (34.3%
FT                   identity in 443 a a overlap), and to PRPD_ECOLI|P77243 prpd
FT                   protein from Escherichia coli (483aa), FASTA scores: opt:
FT                   234, E(): 3.3e-08, (27.0% identity in 429 aa overlap)."
FT                   /db_xref="GOA:O06582"
FT                   /db_xref="InterPro:IPR005656"
FT                   /db_xref="UniProtKB/TrEMBL:O06582"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09041.1"
FT                   /translation="MPDQDTKVRFFRVFCWCPVLRMVRIMLMHAVRAWRSADDFPCTEH
FT                   MAYKIAQVAADPVDVDPEVADMVCNRIIDNAAVSAASMVRRPVTVARHQALAHPVRHGA
FT                   KVFGVEGSYSADWAAWANGVAARELDFHDTFLAADYSHPADNIPPLVAVAQQLGVCGAE
FT                   LIRGLVTAYEIHIDLTRGICLHEHKIDHVAHLGPAVAAGIGTMLRLDQETIYHAIGQAL
FT                   HLTTSTRQSRKGAISSWKAFAPAHAGKVGIEAVDRAMRGEGSPAPIWEGEDGVIAWLLA
FT                   GPEHTYRVPLPAPGEPKRAILDSYTKQHSAEYQSQAPIDLACRLRERIGDLDQIASIVL
FT                   HTSHHTHVVIGTGSGDPQKFDPDASRETLDHSLPYIFAVALQDGCWHHERSYAPERARR
FT                   SDTVALWHKISTVEDPEWTRRYHCADPAKKAFGARAEVTLHSGEVIVDELAVADAHPLG
FT                   TRPFERKQYVEKFTELADGVVEPVEQQRFLAVVESLADLESGAVGGLNVLVDPRVLDKA
FT                   PVIPPGIFR"
FT   CDS             222345..223526
FT                   /transl_table=11
FT                   /gene="gltA1"
FT                   /locus_tag="Rv1131"
FT                   /product="PROBABLE CITRATE SYNTHASE I GLTA1"
FT                   /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE (KREBS
FT                   CYCLE) [CATALYTIC ACTIVITY: Citrate + CoA = acetyl-CoA +
FT                   H2O + oxaloacetate]."
FT                   /EC_number="2.3.3.1"
FT                   /note="Rv1131, (MTCY22G8.20), len: 393 aa. Probable gltA1,
FT                   citrate synthase 1 (EC 4.1.3.7), highly similar to
FT                   CISY_MYCSM|P26491 citrate synthase from Mycobacterium
FT                   smegmatis (375 aa), FASTA scores: opt:1942, E(): 0, (80.0%
FT                   identity in 375 aa overlap). Also similar to two other M.
FT                   tuberculosis citrate synthases, Rv0896c|MTCY31.24|gltA2
FT                   (431 aa), FASTA score: (33.1% identity in 381 aa overlap)
FT                   and Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (31.8%
FT                   identity in 371 aa overlap). Contains PS00480 Citrate
FT                   synthase signature. BELONGS TO THE CITRATE SYNTHASE
FT                   FAMILY."
FT                   /db_xref="GOA:O08395"
FT                   /db_xref="InterPro:IPR019810"
FT                   /db_xref="PDB:3HWK"
FT                   /db_xref="UniProtKB/TrEMBL:O08395"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09042.1"
FT                   /translation="MTGPLAAARSVAATKSMTAPTVDERPDIKKGLAGVVVDTTAISKV
FT                   VPQTNSLTYRGYPVQDLAARCSFEQVAFLLWRGELPTDAELALFSQRERASRRVDRSML
FT                   SLLAKLPDNCHPMDVVRTAISYLGAEDPDEDDAAANRAKAMRMMAVLPTIVAIDMRRRR
FT                   GLPPIAPHSGLGYAQNFLHMCFGEVPETAVVSAFEQSMILYAEHGFNASTFAARVVTST
FT                   QSDIYSAVTGAIGALKGRLHGGANEAVMHDMIEIGDPANAREWLRAKLARKEKIMGFGH
FT                   RVYRHGDSRVPTMKRALERVGTVRDGQRWLDIYQVLAAEMASATGILPNLDFPTGPAYY
FT                   LMGFDIASFTPIFVMSRITGWTAHIMEQATANALIRPLSAYCGHEQRVLPGTF"
FT   misc_feature    223176..223214
FT                   /note="PS00480 Citrate synthase signature"
FT   CDS             223538..225268
FT                   /transl_table=11
FT                   /locus_tag="Rv1132"
FT                   /product="CONSERVED MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1132, (MTCY22G8.21), len: 576 aa. Conserved
FT                   membrane protein, similar to O06827|Rv1431|MTCY493.23C
FT                   membrane protein from Mycobacterium tuberculosis (589 aa),
FT                   fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa
FT                   overlap)."
FT                   /db_xref="UniProtKB/TrEMBL:O06583"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09043.1"
FT                   /translation="MGFLQPRLPDIDLAEWSQGSRSQKIRPMAQHWAEVGFGTPVLLHL
FT                   FYVAKILLYVLVGWLIVLTTKGIDGFTDAAAWYAEPIVFEKVVLYTMLFEVIGLGCGFG
FT                   PLNNRFFPPMGSILYWMRFGTIRLPPWPDRVPWTRGTKRKPVDVALYALLVMMLLSALF
FT                   TDGAGPIPELGTTVGLLPAWQIVLILLLLGVLGLRDKVIFLAARGEVYATLTVTFLFGR
FT                   LNGIDMIVAAKLVFLVIWIGAATSKLNRHFPFVISTMMSNNPLFRPRFIKRMFFKKFPG
FT                   DLRPGLLSRIVAHVSTVIEMCVPVVLFVAHGGWPTVVAATIMVCFHLGILTAIPMGVPL
FT                   EWNVFMIFGVLSLFVGHACLGLADVKNPVPLAILIAVVAGIVIAGNVFPRKISFLAAMR
FT                   YYAGNWDTTLWCIKPSAEDKINRGIVAIASMPAAQLERFYGKDRAQIPMYLGYAFRAMN
FT                   SHGRALFTLAHRAMAGHDEDDYVITDGERVCSTAVGWNFGDGHLHNEQLIAAMQQRCGF
FT                   QPGEVRVVLLDAQPIHRQTQEYRLVDAATGEFERGYVRVADMVNRQPWDDDVPVHVLPG
FT                   "
FT   CDS             complement(225280..227559)
FT                   /transl_table=11
FT                   /gene="metE"
FT                   /locus_tag="Rv1133c"
FT                   /product="PROBABLE
FT                   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE
FT                   METHYLTRANSFERASE METE (methionine synthase, vitamin-B12
FT                   independent isozyme)"
FT                   /function="CATALYZES THE TRANSFER OF A METHYL GROUP FROM
FT                   5-METHYLTETRAHYDROFOLATE TO HOMOCYSTEINE RESULTING IN
FT                   METHIONINE FORMATION (PATHWAY: TERMINAL STEP IN THE DE NOVO
FT                   BIOSYNTHESIS OF METHIONINE) [CATALYTIC ACTIVITY :
FT                   5-METHYLTETRAHYDROPTEROYLTRI-L-GLUTAMATE + L- HOMOCYSTEINE
FT                   = TETRAHYDROPTEROYLTRI-L-GLUTAMATE + L-METHIONINE.]"
FT                   /EC_number="2.1.1.14"
FT                   /note="Rv1133c, (MTC22G8.22), len: 759 aa (start site
FT                   chosen by homology). Probable metE,
FT                   5-methyltetrahydropteroyltriglutamate--homocysteine
FT                   methyltransferase (EC 2.1.1.14), highly similar to others
FT                   e.g. METE_ECOLI|P25665 Escherichia coli (752 aa), FASTA
FT                   scores: opt: 2251, E(): 0, (48.1% identity in 756 aa
FT                   overlap). Equivalent to Z94723|MLCB33_14 metE from M.
FT                   leprae (760 aa) (85.3% identity in 755 aa overlap). BELONGS
FT                   TO THE VITAMIN-B12 INDEPENDENT METHIONINE SYNTHASE FAMILY."
FT                   /db_xref="GOA:P65340"
FT                   /db_xref="InterPro:IPR006276"
FT                   /db_xref="UniProtKB/Swiss-Prot:P65340"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09044.1"
FT                   /translation="MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEA
FT                   VAATLRRDTWSALAAAGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAA
FT                   ARGTDQIAPLEMTKWFDTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVII
FT                   GPITFLLLSKAVDGAGAPIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDA
FT                   PALAEAVYTALCSVSNRPAIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGV
FT                   PELAGKTLVAGVVDGRNVWRTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPET
FT                   DLDDALRSWLAFGAEKVREVVVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQI
FT                   RARIEAIVASGAHRGNAAQRRASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEI
FT                   DEAEYVRRMRQEITEVIALQERLGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQS
FT                   YGSRCVRPPILYGDVSRPRAMTVEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPL
FT                   ADTANQVALAIRDETVDLQSAGIAVIQVDEPALRELLPLRRADQAEYLRWAVGAFRLAT
FT                   SGVSDATQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAIGFANGVGP
FT                   GVYDIHSPRVPSAEEMADSLRAALRAVPAERLWVNPDCGLKTRNVDEVTASLHNMVAAA
FT                   REVRAG"
FT   CDS             228135..228371
FT                   /transl_table=11
FT                   /locus_tag="Rv1134"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1134, (MTCI65.01), len: 78 aa. Hypothetical
FT                   unknown protein. TBparse score is 0.838."
FT                   /db_xref="UniProtKB/TrEMBL:O06534"
FT                   /protein_id="CAB09022.1"
FT                   /translation="MAAYQKFGQEHAAAIRGGAVLHPTATATTVRVTGARGGDVVTGDG
FT                   PYEAADLDEQGPFPMETVYLWEDGPNGTTRMTL"
FT   CDS             complement(228485..230341)
FT                   /transl_table=11
FT                   /gene="PPE16"
FT                   /locus_tag="Rv1135c"
FT                   /product="PPE FAMILY PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1135c, (MTCI65.02c), len: 618 aa. Member of the
FT                   Mycobacterium tuberculosis PPE family of glycine-rich
FT                   proteins. Similar to Rv2356c (59.6% identity in 627 aa
FT                   overlap); etc.. TBparse score is 0.881."
FT                   /db_xref="InterPro:IPR002989"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q79FS0"
FT                   /protein_id="CAE55364.1"
FT                   /translation="MSFLVLPPEVNSALMFAGAGSGPTLAAAAAWDGLAAELGQAANSF
FT                   SSATAALADTAWQGPAATAMAAAAAPYASWLSTAATRALSAAAQAKAAAAVYEAARAAT
FT                   VDPLLVAANRHQLVSLVLSNLFGQNAPAIAATEAAYEQLWAADVAAMVSYHSGASAVAA
FT                   QLAPWAQAVRALPNPTAPALASGPAALAIPALGIGNTGIGNIFSIGNIGDYNLGNGNTG
FT                   NANLGSGNTGQANLGSGNTGFFNFGSGNTANTNFGSGNLGNLNLGSGNDGNGNFGLGNI
FT                   GDGNRGSGNVGSFNFGTANAGSFNVGSANHGSPNVGFANLGNNNLGIANLGNNNLGIAN
FT                   LGNNNIGIGLTGDNMIGIGALNSGIGNLGFGNSGNNNIGLFNSGNNNIGFFNSGDSNFG
FT                   FFNSGDTNTGFGNAGFTNTGFGNAGSGNFGFGNAGNNNFGFGNSGFENMGVGNSGAYNT
FT                   GSFNSGTLNTGDLNSGDFNTGWANSGDINTGGFHSGDLNTGFGSPVDQPVMNSGFGNIG
FT                   TGNSGFNNSGDANSGFQNTNTGAFFIGHSGLLNSGGGQHVGISNSGTGFNTGLFNTGFN
FT                   NTGIGNSATNAAFTTTSGVANSGDNSSGGFNAGNDQSGFFDG"
FT   CDS             230527..230769
FT                   /transl_table=11
FT                   /locus_tag="Rv1135A"
FT                   /product="POSSIBLE ACETYL-CoA ACETYLTRANSFERASE
FT                   (ACETOACETYL-CoA THIOLASE)"
FT                   /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION
FT                   [CATALYTIC ACTIVITY: 2 ACETYL-CoA = CoA +
FT                   ACETOACETYL-COA]."
FT                   /EC_number="2.3.1.9"
FT                   /note="Rv1135A, len: 80 aa. Possible acetyl-CoA
FT                   acetyltransferase (EC 2.3.1.9) (possible gene fragment),
FT                   highly similar to other acetyl-CoA acetyltransferases e.g.
FT                   C-terminal part of
FT                   Rv3556c|Z92774|MTCY6G11_2|MTCY06G11.03|fadA6 ACETYL-COA
FT                   ACETYLTRANSFERASE from Mycobacterium tuberculosis (386 aa),
FT                   FASTA scores: opt: 219, E(): 5.7e-09, (63.6% identity in 55
FT                   aa overlap)."
FT                   /db_xref="GOA:Q8VK64"
FT                   /db_xref="HSSP:1AFW"
FT                   /db_xref="InterPro:IPR002155"
FT                   /db_xref="UniProtKB/TrEMBL:Q8VK64"
FT                   /protein_id="CAE55365.1"
FT                   /translation="MQLGNQNTMRFAGRPQRFRQSAYPLFNPNSAIALGHPFGGSGARL
FT                   MTTVLHHMPDKGIRYGLQTMCEGRGQANATIVELL"
FT   CDS             230819..231160
FT                   /transl_table=11
FT                   /locus_tag="Rv1136"
FT                   /product="POSSIBLE ENOYL-CoA HYDRATASE"
FT                   /function="INVOLVED IN CARNITINE METABOLISM."
FT                   /EC_number="5.-.-.-"
FT                   /note="Rv1136, (MTCI65.03), len: 113 aa. Probable enoyl-CoA
FT                   hydratase (possible gene fragment) (EC 5.-.-.-). Some
FT                   similarity to N-terminus of carnitine racemases and
FT                   enoyl-CoA hydratases (but much shorter) e.g. I41014
FT                   carnitine racemase from Escherichia coli (297 aa), FASTA
FT                   scores: opt: 258, E(): 2.5e-11, (44.5% identity in 110 aa
FT                   overlap); and Rv0222 putative enoyl-CoA hydratase from M.
FT                   tuberculosis (262 aa). TBparse score is 0.871."
FT                   /db_xref="GOA:O06536"
FT                   /db_xref="HSSP:1MJ3"
FT                   /db_xref="InterPro:IPR001753"
FT                   /db_xref="UniProtKB/TrEMBL:O06536"
FT                   /protein_id="CAB09024.1"
FT                   /translation="MVITINRPEARNAVNGAVSIVVGDALEEAHDNPDVRAVVITGAGD
FT                   KSLCAGADLKAIARRENPYHPHHGEWGIAGYRHHFIDKPTSAAVSGTALDDGAEPALAS
FT                   DLVVADEHT"
FT   CDS             complement(231300..231668)
FT                   /transl_table=11
FT                   /locus_tag="Rv1137c"
FT                   /product="HYPOTHETICAL PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1137c, (MTCI65.04c), len: 122 aa. Hypothetical
FT                   unknown protein."
FT                   /db_xref="UniProtKB/TrEMBL:O06537"
FT                   /protein_id="CAB09025.1"
FT                   /translation="MLSARCHIRHIGSPGKDARCAHLSATLRPGIGISPTNVGNATVLA
FT                   DGTPAKPIQGAETMQRARHTGSCFSANARGPAISSGNPSRAGCGVPSSTTTPSSTPQAI
FT                   RLLACTDSDALTVTRTAR"
FT   CDS             complement(231685..232701)
FT                   /transl_table=11
FT                   /locus_tag="Rv1138c"
FT                   /product="POSSIBLE OXIDOREDUCTASE"
FT                   /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv1138c, (MTCI65.05c), len: 338 aa. Possible
FT                   oxidoreductase (EC 1.-.-.-), similar to Q9EWQ8 PUTATIVE
FT                   OXIDOREDUCTASE from Streptomyces coelicolor (343 aa). Also
FT                   similar to many Mycobacterium tuberculosis hypothetical
FT                   proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta
FT                   scores: opt: 89, E(): 4.5e-09, (24.6% identity in 358 aa
FT                   overlap). TBparse score is 0.929."
FT                   /db_xref="GOA:O06538"
FT                   /db_xref="InterPro:IPR003042"
FT                   /db_xref="UniProtKB/TrEMBL:O06538"
FT                   /protein_id="CAB09026.1"
FT                   /translation="MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPIDKAC
FT                   GEGLMPGGLAELTSLGVDPVGLPFHGIAYVGEHRRVQARFRTGPGRGVRRTTLHAALAA
FT                   RAKEQDTEWIRSRVATIQQDAHGVTAAGVRAKWLVAADGLHSAVRRAVGIKATAGTPRR
FT                   YGVRWHYRLPVWSDFVEVHWSRWGEAYVTPVEPDLVGVAILSRQRPELAWFPSLAHHLQ
FT                   DASRGHARGCGPLRQVVSRRVAGRVLLVGDAAGYEDALTGEGISLAVKQAAAAVSAIVD
FT                   DTPASYEAAWHRITRDYRLVTRGLVLASTPRAARRAIVPLCALLPTAFRYGVNILAY"
FT   CDS             complement(232698..233198)
FT                   /transl_table=11
FT                   /locus_tag="Rv1139c"
FT                   /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1139c, (MTCI65.06c), len: 166 aa. Conserved
FT                   hypothetical membrane protein. Highly similar to
FT                   P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein,
FT                   YBPQ (168 aa), FASTA scores: opt: 446, E(): 2.2e-26, (38.4%
FT                   identity in 164 aa overlap). Some similarity to
FT                   Mycobacterium tuberculosis hypothetical proteins, Rv0740,
FT                   Rv0750. TBparse score is 0.911."
FT                   /db_xref="GOA:O06539"
FT                   /db_xref="InterPro:IPR007269"
FT                   /db_xref="UniProtKB/TrEMBL:O06539"
FT                   /protein_id="CAB09027.1"
FT                   /translation="MYYLLILAVVFERLAELVVAQRNARWSFAQGGKEFGRPHYVVMVI
FT                   LHTALLLGCVVEPWALHRPFIPWLGWPMLAVVVASQGLRWWCVKSLGKRWNTRVIVLPH
FT                   ATLVRRGPYRWMRHPNYVAVVAEGFALPLVHTAWLTALVFTLANATLLTVRLRVENSVL
FT                   GYI"
FT   CDS             233560..234408
FT                   /transl_table=11
FT                   /locus_tag="Rv1140"
FT                   /product="PROBABLE INTEGRAL MEMBRANE PROTEIN"
FT                   /function="UNKNOWN"
FT                   /note="Rv1140, (MTCI65.07), len: 282 aa. Probable integral
FT                   membrane protein. Weak similarity in C-terminus to
FT                   hypothetical Escherichia coli proteins YPRA and YPRB,
FT                   possibly membrane-bound e.g. YPRA_ECOLI HYPOTHETICAL 24.3
FT                   kDa PROTEIN (URF 1) (217 aa), FASTA scores: opt: 166, E():
FT                   0.00062, (31.0% identity in 158 aa overlap). TBparse score
FT                   is 0.927."
FT                   /db_xref="GOA:O06540"
FT                   /db_xref="InterPro:IPR003675"
FT                   /db_xref="UniProtKB/TrEMBL:O06540"
FT                   /protein_id="CAB09028.1"
FT                   /translation="MPRDYTAPRWAHAWAGEPRPARWHPANQPAHPDHSNRESPACMSQ
FT                   STTPYRSSVLAEFRRAITNVAVPHHEPPGIVRRRRVVVGVTLVIGAVMLGFSLRRTPGE
FT                   SSFYWLTLALAAVWIAGALMSGPLHLGGICWRGRNQRPVITGTTVGLLLAGIFGVGAMI
FT                   VRAIPGAAEPIARVLQFAHQGTLLPILLITLINGIAEEMFFRGALYTALGRRYPVTIST
FT                   VLYVGATMASANLMLGFAAIFVGTVCALERRASGGVLAPILTHFVWGLIMVFALPPLFA
FT                   V"
FT   CDS             complement(234416..235222)
FT                   /transl_table=11
FT                   /gene="echA11"
FT                   /locus_tag="Rv1141c"
FT                   /product="PROBABLE ENOYL-CoA HYDRATASE ECHA11 (ENOYL
FT                   HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)"
FT                   /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING
FT                   SPECIFIC COMPONENTS (BY SIMILARITY) [CATALYTIC ACTIVITY:
FT                   (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]."
FT                   /EC_number="4.2.1.17"
FT                   /note="Rv1141c, (MTCI65.08c), len: 268 aa. Probable echA11,
FT                   enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g.
FT                   P24162|ECHH_RHOCA PROBABLE ENOYL-CoA HYDRATASE from
FT                   Rhodobacter capsulatus(257 aa); CAA66096.1|X97452 enoyl-CoA
FT                   isomerase from Escherichia coli (262 aa), FASTA scores:
FT                   opt: 513, E():1e-25, (36.1% identity in 249 aa overlap);
FT                   etc. Also similarity with naphthoate synthases. Also highly
FT                   similar to downstream ORF Rv1142c|MTCI65.09|echA10 PROBABLE
FT                   ENOYL-CoA HYDRATASE from Mycobacterium tuberculosis (268
FT                   aa), FASTA scores: opt: 1225, E(): 0, (72.3% identity in
FT                   267 aa overlap). TBparse score is 0.910."
FT                   /db_xref="GOA:O06541"
FT                   /db_xref="InterPro:IPR001753"
FT                   /db_xref="UniProtKB/TrEMBL:O06541"
FT                   /protein_id="CAB09029.1"
FT                   /translation="MPDSGIAALTPVTGLNVTLTDRVLSVRINRPSSLNSLTVPILTGI
FT                   ADTLERAAADPVVKVVRLGGVGRGFSSGVSMSVDDVWGGGPPTAIVEEANRAVRAVAAL
FT                   PHPVVAVVQGPAVGVAVSLALACDFILASDSAFFMLANTKVALMPDGGASALVAAATGR
FT                   IRAMRLALLAEQLPAREALAWGLISAVYPDSDFEAEVDKVISRLLAGPALAFAQAKNAI
FT                   NAAALTELEPTFARELDGQEVLLRTHDFAEGAAAFLQRRTPNFTGS"
FT   CDS             complement(235365..236171)
FT                   /transl_table=11
FT                   /gene="echA10"
FT                   /locus_tag="Rv1142c"
FT                   /product="PROBABLE ENOYL-CoA HYDRATASE ECHA10 (ENOYL
FT                   HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)"
FT                   /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING
FT                   SPECIFIC COMPONENTS (BY SIMILARITY) [CATALYTIC ACTIVITY:
FT                   (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]."
FT                   /EC_number="4.2.1.17"
FT                   /note="Rv1142c, (MTCI65.09c), len: 268 aa. Probable echA10,
FT                   enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g.
FT                   CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli
FT                   (262 aa), FASTA scores: opt: 525, E(): 1.3e-26, (35.1%
FT                   identity in 251 aa overlap); NP_420658.1|NC_002696
FT                   enoyl-CoA hydratase/isomerase family protein from
FT                   Caulobacter crescentus (267 aa); NP_438092.1|NC_003078
FT                   putative enoyl-CoA hydratase protein from Sinorhizobium
FT                   meliloti (263 aa); etc. Also similarity with naphthoate
FT                   synthases. Also highly similar to upstream ORF
FT                   Rv1141c|MTCI65.08c|echA11 PROBABLE ENOYL-CoA HYDRATASE from
FT                   Mycobacterium tuberculosis (268 aa), FASTA score: opt:
FT                   1225, E(): 0, (72.3% identity in 267 aa overlap). TBparse
FT                   score is 0.891."
FT                   /db_xref="GOA:O06542"
FT                   /db_xref="InterPro:IPR001753"
FT                   /db_xref="UniProtKB/TrEMBL:O06542"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="CAB09030.1"
FT                   /translation="MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVLAGM
FT                   ADAIEGAATDPRVKVVRLGGAGRGFSSGGAISVDDVWASGPPTDTVAEANRTVRAIVAL
FT                   PQPVVAVVQGPTVGCGVSLALACDLVLASDNAFFMLAHTNVGLMPDGGASALVQAAIGR
FT                   IRAMHMALLPDRVPAAEALSWGLVSAVYPAADFDAEVDKLISRLLAGPALAIAKTKNAI
FT                   NAATLTELAPTLLRELDGQALLLRTDDFAEGATAFQQRRTPMFTGR"
FT   CDS             236275..237357
FT                   /transl_table=11
FT                   /gene="mcr"
FT                   /locus_tag="Rv1143"
FT                   /product="PROBABLE ALPHA-METHYLACYL-CoA RACEMASE MCR
FT                   (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase
FT                   )"
FT                   /function="REQUIRED FOR BILE ACID SYNTHESIS AND FOR
FT                   CATABOLISM OF BRANCHED-CHAIN FATTY ACIDS"
FT                   /EC_number="5.1.99.4"
FT                   /note="Rv1143, (MTCI65.10), len: 360 aa. Probable mcr,
FT                   alpha-methylacyl-CoA racemase (EC 5.1.99.4). Strong
FT                   similarity to other alpha-methylacyl-CoA racemases and also
FT                   some similarity to L-carnitine dehydratase (EC 4.2.1.89)
FT                   e.g. U89905|g1552373 methylacyl-CoA racemase alpha from
FT                   Norway rat (361 aa), FASTA scores: opt: 1035, E():0, (47.2%
FT                   identity in 339 aa overlap). Equivalent to (but longer
FT                   than) Z94723|MLCB33_13 Mycobacterium leprae (253 aa) (85.3%
FT                   identity in 245 aa overlap). Also similar to Mycobacterium
FT                   tuberculosis putative racemases Rv0855, Rv1866, Rv3272.
FT                   TBparse score is 0.906."
FT                   /db_xref="GOA:O06543"
FT                   /db_xref="InterPro:IPR003673"
FT                   /db_xref="PDB:1X74"
FT                   /db_xref="UniProtKB/TrEMBL:O06543"
FT                   /protein_id="CAB09031.1"
FT                   /translation="MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDGI
FT                   SRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVTERLGLGPEECAKVND
FT                   RLIYARMTGWGQTGPRSQQAGHDINYISLNGILHAIGRGDERPVPPLNLVGDFGGGSMF
FT                   LLVGILAALWERQSSGKGQVVDAAMVDGSSVLIQMMWAMRATGMWTDTRGANMLDGGAP
FT                   YYDTYECADGRYVAVGAIEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFAS
FT                   HDRDHWGAVFANSDACVTPVLAFGEVHNEPHIIERNTFYEANGGWQPMPAPRFSRTASS
FT                   QPRPPAATIDIEAVLTDWDG"
FT   CDS             237369..238121
FT                   /transl_table=11
FT                   /locus_tag="Rv1144"
FT                   /product="PROBABLE SHORT-CHAIN TYPE
FT                   DEHYDROGENASE/REDUCTASE"
FT                   /function="UNKNOWN; SUPPOSED INVOLVED IN CELLULAR
FT                   METABOLISM."
FT                   /EC_number="1.-.-.-"
FT                   /note="Rv1144, (MTCI65.11), len: 250 aa. Probable
FT                   short-chain dehydrogenase/reductase (EC 1.-.-.-), highly
FT                   similar to various dehydrogenases e.g.
FT                   NP_104056.1|NC_002678 3-hydroxyacyl-CoA dehydrogenase type
FT                   II from Mesorhizobium loti (253 aa); NP_251244.1|NC_002516
FT                   probable short-chain dehydrogenase from Pseudomonas
FT                   aeruginosa (255 aa); AAK15008.1|AF233685_1|AF233685 short
FT                   chain L-3-hydroxyacyl-CoA dehydrogenase from Mus musculus
FT                   (261 aa); HSU73514|g1778354|XH98G2 human short-chain
FT                   alcohol dehydrogenase from Homo sapie