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EBI DbfetchID BX842574; SV 1; linear; genomic DNA; STD; PRO; 349564 BP. XX AC BX842574; AL021943; AL021958-AL021959; AL022004; Z73101; Z80226; Z84395; AC Z92772; Z95210; Z95618; Z95972; Z96797; Z97182; XX DT 21-NOV-2003 (Rel. 77, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 3/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-349564 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF00379; ydaO-yuaA. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..349564 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT CDS 137..859 FT /transl_table=11 FT /locus_tag="Rv0586" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (GNTR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0586, (MTCY19H5.36c), len: 240 aa. Probable FT transcriptional regulator, GntR family, similar to many FT e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase FT operon regulatory protein from Escherichia coli (258 aa), FT FASTA scores: opt: 225, E(): 9.3e-08, (26.7% identity in FT 232 aa overlap); etc. Also similar to other M. tuberculosis FT transcriptional regulators GntR proteins e.g. Rv3060c, FT Rv0792c, etc. Contains PS00043 Bacterial regulatory FT proteins, gntR family signature and probable helix-turn FT helix motif from aa 35-56 (Score 1531, +4.40 SD)." FT /db_xref="GOA:P67741" FT /db_xref="InterPro:IPR000524" FT /db_xref="InterPro:IPR011711" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67741" FT /protein_id="CAB09952.1" FT /translation="MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLG FT VSRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSI FT LEARLRNFPKVAELAAERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVDSAG FT SIVDRLMYNAFRAAYEPTLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLL FT ELANTSLMAVLVSQASRQ" FT misc_feature 245..310 FT /note="PS00043 Bacterial regulatory proteins, gntR family FT signature" FT CDS 856..1653 FT /transl_table=11 FT /gene="yrbE2A" FT /locus_tag="Rv0587" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE2A" FT /function="UNKNOWN" FT /note="Rv0587, (MTCY19H5.35c), len: 265 aa. yrbE2A, FT hypothetical unknown integral membrane protein, part of FT mce2 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); FT O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly FT similar to conserved hypothetical integral membrane FT proteins of the yrbEA type, e.g. P45392|YRBE_ECOLI FT hypothetical 27.9 kDa protein from Escherichia coli (260 FT aa), FASTA scores: opt: 287, E(): 6.1e-12, (21.5% identity FT in 256 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical FT protein from Haemophilus influenzae (261 aa), FASTA scores: FT opt: 311, E(): 1.8e-83, (24.2% identity in 265 aa overlap); FT NP_302654.1|NC_002677 conserved membrane protein from FT Mycobacterium leprae (267 aa); etc." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:O07791" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09951.1" FT /translation="MTTHAVIITYLRDQTQPAVDAIGGFYRTCVLTGKALVRRPFHWRE FT AIEQGWFITSVSLLPTLAVSIPLTVLIIFTLNILLAEFGAADISGAGAALGAVTQLGPL FT TTVLVIAGAGATAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVVAATIVAALLNGA FT VITIGLVGGFVFSVFIQHVSAGAYVGTLTLVTGLPEVIISVVKSATFGLIAGLVGCYRG FT LTTKGGPKGVGTAVNETLVLCVIALFATNVVLTTIGVRFGTGH" FT CDS 1655..2542 FT /transl_table=11 FT /gene="yrbE2B" FT /locus_tag="Rv0588" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE2B" FT /function="UNKNOWN" FT /note="Rv0588, (MTCY19H5.34c), len: 295 aa. yrbE2B, FT hypothetical unknown integral membrane protein, part of FT mce2 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); FT O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly FT similar to conserved hypothetical integral membrane FT proteins of the yrbEB type, e.g. P45392|YRBE_ECOLI FT hypothetical 27.9 kDa protein from Escherichia coli (260 FT aa), FASTA scores: opt: 232, E(): 8.4e-08, (22.1 % identity FT in 267 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical FT protei from Haemophilus influenzae (261 aa), FASTA scores: FT opt: 234, E(): 6.3e-08, (24.2% identity in 215 aa overlap); FT NP_302655.1|NC_002677 conserved membrane protein from FT Mycobacterium leprae (289 aa); etc." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:O07790" FT /protein_id="CAB09950.1" FT /translation="MVESSTASAAAVLRARYPRTAASLDRYGGGTARRLERTGTFARFT FT RISVVQIGWALRRYRRETLRLVAEIGMGTGAMAVVGGTVAIIGFVTLSGGSLIAIQGFA FT SLGNIGVEAFTGFFAALANTRVAAPIVSGVALAATVGAGATAQLGAMRISEEIDALEVM FT GIKSISFLVSTRILGGLVVIMPLYALALDMAFTSGQVVTTVFYGQSNGTYEHYFRTFLR FT PEDVGWSVVEVVIIAVVVMITHCYYGYTASGGPVGVGQAVGRSMRFSLVSVVVVVLLAE FT LALYGVDPNFNLTV" FT CDS 2548..3762 FT /transl_table=11 FT /gene="mce2A" FT /locus_tag="Rv0589" FT /standard_name="mce2" FT /product="MCE-FAMILY PROTEIN MCE2A" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0589, (MTCY19H5.33c), len: 404 aa. mce2A; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); FT O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also FT highly similar to others e.g. FT AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry FT protein from Mycobacterium bovis BCG (454 aa); FT NP_302656.1|NC_002677 putative cell invasion protein from FT Mycobacterium leprae (441 aa); CAC12798.1|AL445327 putative FT secreted protein from Streptomyces coelicolor (418 aa); FT etc. Also highly similar, but longer 21 aa, to FT P72013|CAA50257.1|X70901|MTCI28.08 Mcep protein from FT Mycobacterium tuberculosis (432 aa), FASTA scores: opt: FT 1324, E(): 0, (62.6% identity in 436 aa overlap). Contains FT a possible N-terminal signal or anchor sequence. Note that FT previously known as mce2." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:Q79FY7" FT /protein_id="CAE55301.1" FT /translation="MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTPKTE FT LTMVAFRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLDVNPRYISLIPVN FT VVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVGSVTTEFNTLFETITSIAEKVD FT PIELNATLSAVAQALDGLGGKFGESIVNGNQILAQLNPRLPQLGYDVRRLADLGEVYVD FT ASPDLWSFLQNALTTARTLTSQQRDLDAALLAATGAGNTGEDVFARGGPYLARAAADLV FT PTATLLDTYSPELFCMIRNFHDAAPKVADAVGGNGYSLAAAGTILGAPNPYVYPDNLPR FT VNAHGGPGGRPGCWQTITRELWPAPYLVMDTGASLAPYNHVELGQPMFTEYVWGRQYGE FT NTINP" FT CDS 3759..4586 FT /transl_table=11 FT /gene="mce2B" FT /locus_tag="Rv0590" FT /product="MCE-FAMILY PROTEIN MCE2B" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0590, (MTCY19H5.32c), len: 275 aa. mce2B; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07414|Rv0170|MTCI28.10|mce1B (346 aa); FT O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly FT similar to others e.g. NP_302657.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (346 aa); FT P45391|YRBD_ECOLI hypothetical 19.6 kDa protein from FT Escherichia coli (183 aa), FASTA scores: opt: 160, E(): FT 0.00099, (28.3% identity in 166 aa overlap); FT P45029|YRBD_HAEIN|HI1085 hypothetical protein from FT Haemophilus influenzae (167 aa), FASTA scores: opt: 135, FT E():0.035, (25.9% identity in 143 aa overlap); etc. FT Contains possible N-terminal signal or anchor sequence." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O07788" FT /protein_id="CAB09962.1" FT /translation="MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTH FT VSGLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYLNLIG FT DRYLELGRGHSGQRLAPGATIPLEHTHPALDLDALLGGFRPLFQTLDPDKVNSIASSII FT TVFQGQGATINDILDQTASLTATLADRDHAIGEVVNNLNTVLATTVKHQTEFDRTVDKL FT EVLITGLKNRADPLAAAAAHISSAAGTLADLLGRIVHCCTAASGTSRASSSRS" FT CDS 4535..4789 FT /transl_table=11 FT /locus_tag="Rv0590A" FT /product="MCE-FAMILY RELATED PROTEIN" FT /function="UNKNOWN, BUT COULD BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0590A, len: 84 aa. Probable continuation of FT mce2B|Rv0590. Can find no frameshift to account for this. FT Possible nucleotide G missing at 688793 as there are 5 in FT Mycobacterium bovis but only 4 in CDC1551. Strong FT similarity to C-terminus of other Mce proteins e.g. FT AL583926|AL583926_38 from Mycobacterium leprae strain TN FT (346 aa), FASTA scores: E(): 1.2e-20, (67.85% identity in FT 84 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q8VKI0" FT /protein_id="CAE55302.1" FT /translation="MLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRIIGRAGGIYG FT DFFNFYLCDISLKVNGLQPGGPVRTVKLFGQPTGRCTPQ" FT CDS 4786..6231 FT /transl_table=11 FT /gene="mce2C" FT /locus_tag="Rv0591" FT /product="MCE-FAMILY PROTEIN MCE2C" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0591, (MTCY19H5.31c), len: 481 aa. mce2C; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07415|R0171|MTCI28.11|mce1C (515 aa); FT O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly FT similar to others e.g. NP_302658.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (519 aa); FT CAC12796.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (351 aa); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), and may contain FT N-terminal signal or anchor sequence. Has highly Pro-rich FT C-terminus." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="InterPro:IPR008360" FT /db_xref="UniProtKB/TrEMBL:O07787" FT /protein_id="CAB09961.1" FT /translation="MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFATPTYYAQ FT FADTGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLPGKTIGMQSRAAIRTDTILG FT RKNLEIEPRGSEPLKPNGFLPLAQTTTPYQIYDAFVDVTKAATGWDIDAVKRSLNVLSE FT TFDQTAPHLSAALEGVKAFSDTVGRRGEQIEQLLANANRIARVLGDRSEQVNGLLVNAK FT TLLAAFKQRSQALRILLTNVSEASAQVSGLITDNPNLNHVLAQLRTVSEELVKRKNELA FT DVAVLLGRYTAALTEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPENFWRSAG FT LPEFRWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPCSYTPAAGALPRPDTPL FT PCAGATVGPFGGPDFPAPLDVQPSPPNPDGPPPTPGILSAGRPGEPAPAVPGIPMPLPP FT NAPPGARTQPLEPFPDGTGGSNQ" FT misc_feature 5026..5049 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 6228..7754 FT /transl_table=11 FT /gene="mce2D" FT /locus_tag="Rv0592" FT /product="MCE-FAMILY PROTEIN MCE2D" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0592, (MTCY19H5.30c), len: 508 aa. mce2D; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07416|Rv0172|MTCI28.12|mce1D (530 aa); FT O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly FT similar to others e.g. NP_302659.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (531 aa); FT CAC12795.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich FT C-terminus and may contain N-terminal signal or anchor FT sequence." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O07786" FT /protein_id="CAB09960.1" FT /translation="MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLT FT TTTVVAYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPATATAS FT ILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRDSINGILRQLGPTE FT RQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALTALNEGRGDFVAITRSLALFVSA FT LYQNDQQFVALNENLAEFTDWFTKSDHDLADTVERIDDVLGTVRKFVSDNRSVLAADVN FT NLADATTTLVQPEPRDGLETALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLI FT CSAIQAGSRLGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSEERL FT RPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTANMLTPESLAELLG FT GPDIAPPPPGTNLPGPPNAYDESNPLPPPWYPQPASLPAAGATGQPGPGQ" FT CDS 7751..8959 FT /transl_table=11 FT /gene="lprL" FT /locus_tag="Rv0593" FT /standard_name="mce2E" FT /product="POSSIBLE MCE-FAMILY LIPOPROTEIN LPRL (MCE-FAMILY FT LIPOPROTEIN MCE2E)" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0593, (MTCY19H5.29c), len: 402 aa. Possible lprL FT (alternate gene name: mce2E), lipoprotein which belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E FT (390 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. FT Also highly similar to others e.g. NP_302660.1|NC_002677 FT putative lipoprotein from Mycobacterium leprae (392 aa); FT CAC12794.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (413 aa); etc. Contains possible FT signal sequence and PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O07785" FT /protein_id="CAB09981.1" FT /translation="MRCGVSAGSANGKPNRWTLRCGVSAGHRGSVFLLAVLLAPVVLTS FT CTWRGIANVPLPVGRGMGPDRMTIYVQMPDTLALNTNSRVRVADVWVGTVRDISLRNWI FT ATLTLELEPTVRLPANATAKIGQTSLLGTQHVELAAPPIPSPQPLKSGDTIGLKNSSAY FT PTVERTLASVALILTGGGIVNLDVIQTEILNILDGHAGQIREFLERLATFTAELNNQRG FT DLTRAIDSTNQLLTIIANRNDTLDRVLTDVPPLIEHFADTGQLFADATESLGRFSEVAN FT RALAATRPNLHQTLQSLQRPLRQLERASPYVVGALKLGLTAPFNIDEVPNVIRGDYVNV FT SATFDVTLSALDNALLSGTGISGMLRALEQAWGRDPDTMIPDVRYTPNPNDAPGGPLVE FT RAE" FT misc_feature 7856..7888 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 8964..10514 FT /transl_table=11 FT /gene="mce2F" FT /locus_tag="Rv0594" FT /product="MCE-FAMILY PROTEIN MCE2F" FT /function="UNKNOWN, BUT THOUGHT INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0594, (MTCY19H5.28c), len: 516 aa. mce2F; belongs FT to 24-membered Mycobacterium tuberculosis Mce protein FT family (see citations below), similar to Mycobacterium FT tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 FT aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also FT highly similar to others e.g. NP_302661.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (516 FT aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from FT Mycobacterium avium (80 aa) (similarity on C-terminus); FT CAC12793.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (433 aa); etc. Contains possible FT N-terminal signal or anchor sequence." FT /db_xref="InterPro:IPR003399" FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O07784" FT /protein_id="CAB09959.1" FT /translation="MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVGIGRYTLYAE FT LPRSGGLYRTANVTYRGITIGKVTGVEPTERGARATMSIDNGYQIPTDASANVHSVSAV FT GEQFVDLVSTRTSGPYLRHGQTITTTTVPSQIGPALDAANRGLAVLPKDRVASVLHEAS FT EAVGGLGSSLNRLIEATQAIAHDVRGSLEDIDDIIERSAPIIDSQVNSGNEIARWAANL FT NTLAAQTAQTDPAVRSILANAAPTADQVNATFSDVRESLPQTLANLEVVIDMLKRYHNG FT VEQALVFLPQSGAIAQSVTTEFPGQAGLGVGGLALNQPPPCLTGFLPASEWRSPADTST FT APLPKGTYCRIPMDASNVVRGARNNPCVDVPGKRAATPRECRSNEAYVPGGTNPWYGDP FT NQMLSCPAPAARCDQPVKPGQVIPAPSVNNGINPLPADQLPGTPPPVNDPLQRPGSGTV FT QCNGQQPNPCVYTPSTFPTTIYDVQSGKVVAPDGVVYSVEASTHAGADGWKVMLAPTG" FT CDS complement(10566..10958) FT /transl_table=11 FT /locus_tag="Rv0595c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0595c, (MTCY19H5.27), len: 130 aa. Conserved FT hypothetical protein, similar to other conserved FT hypothetical proteins e.g. Rv0627 (135 aa) and Rv0665 (112 FT aa) from Mycobacterium tuberculosis; and STBB_PSESM|Q52562 FT plasmid stability protein from Pseudomonas syringae (139 FT aa), FASTA scores: opt: 131, E(): 0.0035, (35.2% identity FT in 88 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:O07783" FT /protein_id="CAB09980.1" FT /translation="MNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGV FT LQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAWALLVSKLRAAKLRVPINDSWIAAT FT AVAHGIAILTQDNDYAAMPDVEVITI" FT CDS complement(10955..11212) FT /transl_table=11 FT /locus_tag="Rv0596c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0596c, (MTCY19H5.26), len: 85 aa. Conserved FT hypothetical protein, highly similar in part to other M. FT tuberculosis hypothetical proteins e.g. Rv0626, Rv3181c, FT Rv3385c, Rv3407, etc." FT /db_xref="InterPro:IPR003756" FT /db_xref="InterPro:IPR006442" FT /db_xref="UniProtKB/TrEMBL:O07782" FT /protein_id="CAB09958.1" FT /translation="MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRR FT RQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTTDDVRW" FT CDS complement(11395..12630) FT /transl_table=11 FT /locus_tag="Rv0597c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0597c, (MTCY19H5.25), len: 411 aa. Conserved FT hypothetical protein, highly similar to Rv3179 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (429 FT aa). Also similar to AAF76191.1|AF271296_1|AF271296 FT putative ATP/GTP binding protein from Mycobacterium FT smegmatis (428 aa); Rv2008c|YW09_MYCTU|Q10849 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (441 FT aa), FASTA scores: opt: 270, E(): 3.6e-11, (30.5% identity FT in 416 aa overlap) (N-terminus longer). Also similar to FT other hypothetical proteins e.g. NP_085874.1|NC_002679 FT hypothetical protein from Mesorhizobium loti (435 aa) FT (N-terminus longer). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /db_xref="UniProtKB/TrEMBL:O07781" FT /protein_id="CAB09957.1" FT /translation="MGVVERAIAPSVLAALADTPVVVVNGARQVGKTTLVARLDYPGSS FT EVVSLDDVANRDAARDDPRAFVSRPVDTLVIDEAQLEPGLFRAIKAEVDRDRRPGRFLL FT TGSARLLSAPDMADALVGRVEIIELWPFSQGERAGIADGFVDALFTAPRELIHGSDMRR FT ADLVDRIATGGFPDIVARSPSRRRAWFDNYLTTATQSVIREISPIERLAEMPRVLRLCA FT ARTGAELNVSALANDLSIPARTTAGYLALLEAAFLIHRVPAWSTNLSRKVIRRPKLVVS FT DSGLACHLLGVTGATLDRPGRPLGPLLETFVANEIRKQLTWSTERPSLWHFRDRGGAEV FT DLVLEHPDGRVCGIEVKATSTPRAEDLRGLRYLAERLDDRFQFGVLLTAAPEATPFGPT FT LAALPVSTLWAG" FT misc_feature complement(12532..12555) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(12881..13294) FT /transl_table=11 FT /locus_tag="Rv0598c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0598c, (MTCY19H5.24), len: 137 aa. Conserved FT hypothetical protein; similar to Rv2596|Y0B5_MYCTU|Q50625 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (134 aa), FASTA scores: opt: 254, E(): FT 8.2e-12, (41.5% identity in 130 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:O07780" FT /protein_id="CAB09979.1" FT /translation="MKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAET FT YSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSRTTEHLPRVLAQFEITGGAVYDALV FT ALAAAEHRAELATRDARAKDTYEKIGVHVVVAA" FT CDS complement(13291..13527) FT /transl_table=11 FT /locus_tag="Rv0599c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0599c, (MTCY19H5.23), len: 78 aa. Conserved FT hypothetical protein, similar to Rv2595|Y0B6_MYCTU|Q50626 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (81 aa), FASTA scores: opt: 160, E(): 6.2e-07, FT (35.8% identity in 81 aa overlap). N-terminus shows stong FT similarity with N-terminus of NP_104908.1|NC_002678 FT hypothetical protein from Mesorhizobium loti (89 aa)." FT /db_xref="InterPro:IPR006339" FT /db_xref="InterPro:IPR007159" FT /db_xref="UniProtKB/TrEMBL:O07779" FT /protein_id="CAB09956.1" FT /translation="MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGR FT TARLEEENGVLVATGETTIDDEVVFGLIDSGRK" FT CDS complement(13631..14137) FT /transl_table=11 FT /locus_tag="Rv0600c" FT /product="PROBABLE TWO COMPONENT SENSOR KINASE [SECOND FT PART]" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM." FT /EC_number="2.7.3.-" FT /note="Rv0600c, (MTCY19H5.22), len: 168 aa (probable FT partial CDS). Probable two-component sensor kinase (second FT part) (EC 2.7.3.-), similar to part (C-termini) of many FT others e.g. Q04943|AFQ2_STRCO sensor protein afsq2 from FT Streptomyces coelicolor (535 aa), FASTA scores: opt: 347, FT E(): 1.9e-12, (33.0% identity in 206 aa overlap); etc. Note FT that sequence was checked and no errors were detected, FT which would allow this and the upstream ORF to be joined. FT Start changed since first submission (- 39 aa)." FT /db_xref="GOA:O07778" FT /db_xref="HSSP:1BXD" FT /db_xref="InterPro:IPR003594" FT /db_xref="InterPro:IPR004358" FT /db_xref="InterPro:IPR005467" FT /db_xref="UniProtKB/TrEMBL:O07778" FT /protein_id="CAB09983.2" FT /translation="MPITPLLHESVARFAATGADITTRAEPDLFVSIDPDHLRRILTAV FT LDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRGSG FT LGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPNREH FT DTSDQ" FT CDS complement(14251..14721) FT /transl_table=11 FT /locus_tag="Rv0601c" FT /product="PROBABLE TWO COMPONENT SENSOR KINASE [FIRST FT PART]" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM." FT /EC_number="2.7.3.-" FT /note="Rv0601c, (MTCY19H5.21), len: 156 aa (probable FT partial CDS). Probable two-component sensor kinase (first FT part) (EC 2.7.3.-), similar to part (N-termini) of others FT e.g. Q0375|CUTS_STRLI cuts protein from streptomyces FT lividans (414 aa), FASTA scores: opt: 230, E(): 3.1e-08, FT (39.1% identity in 115 aa overlap). Note that the sequence FT was checked and no errors were detected that would allow FT this and the downstream ORF to be joined." FT /db_xref="GOA:O07777" FT /db_xref="InterPro:IPR003660" FT /db_xref="InterPro:IPR009082" FT /db_xref="UniProtKB/TrEMBL:O07777" FT /protein_id="CAB09955.1" FT /translation="MALVLAAAGAVTVVQFRDAAHEADPDGALRGLTDDITADLVRELV FT TILPIVLVIAAVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWL FT ATTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPTS" FT CDS complement(14765..15526) FT /transl_table=11 FT /gene="tcrA" FT /locus_tag="Rv0602c" FT /product="PROBABLE TWO COMPONENT DNA BINDING FT TRANSCRIPTIONAL REGULATORY PROTEIN TCRA" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM." FT /note="Rv0602c, (MTCY19H5.20), len: 253 aa. Probable tcrA, FT two-component DNA-binding response regulator, highly FT similar to others e.g. NP_107959.1|NC_002678 two-component FT response regulator from Mesorhizobium loti (239 aa); etc. FT Also similar to many other Mycobacterium tuberculosis FT two-component regulators e.g. Q50806|MTCY10G2.16|Rv1033c FT RESPONSE REGULATOR HOMOLOG TRCR (TCRV) (257 aa), FASTA FT score: (47.4 identity in 232 aa overlap); etc." FT /db_xref="GOA:O07776" FT /db_xref="HSSP:1KGS" FT /db_xref="InterPro:IPR001789" FT /db_xref="InterPro:IPR001867" FT /db_xref="InterPro:IPR011006" FT /db_xref="UniProtKB/TrEMBL:O07776" FT /protein_id="CAB09978.1" FT /translation="MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEE FT GHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARG FT AVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRV FT WRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDK FT IDRPFGVTSLETIRGAGYRLRKDGGRHALPR" FT CDS 15583..15894 FT /transl_table=11 FT /locus_tag="Rv0603" FT /product="POSSIBLE EXPORTED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0603, (MTCY19H5.19c), len: 103 aa. Possible FT exported protein with hydrophobic stretch at aa 7-29." FT /db_xref="UniProtKB/TrEMBL:O07775" FT /protein_id="CAB09954.1" FT /translation="MNRIVQFGVSAVAAAAIGIGAGSGIAAAFDGEDEVTGPDADRARA FT AAVQAVPGGTAGEVETETGEGAAAYGVLVTRPDGTRVEVHLDRDFRVLDTEPADGDGG" FT CDS 15966..16916 FT /transl_table=11 FT /gene="lpqO" FT /locus_tag="Rv0604" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPQO" FT /function="UNKNOWN" FT /note="Rv0604, (MTCY19H5.18c), len: 316 aa. Probable lpqO, FT conserved lipoprotein, highly similar to Rv2999|lppY FT PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (321 FT aa), FASTA scores: opt: 1153, E(): 0, (53.2% identity in FT 312 aa overlap). Contains probable N-terminal signal FT sequence and PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="InterPro:IPR011094" FT /db_xref="UniProtKB/TrEMBL:O07774" FT /protein_id="CAB09984.1" FT /translation="MIRRRGARMAALLAAAALALTACAGSDDKGEPDDGGDRGASLATT FT SDADWKPVADILGRTGKLNDGSVYKIGFARSDLSVQTKGVTVAPALSLGSWVAFARTPD FT GQTMLMGDLVVTEDELASVTDAVQAGGLQQTALHKHLLEQSPPIWWTHIAGHGDAADLA FT RAVRSALDATDTPPPASATSGQTSLDLDTAAIDEALGRSGTIAGGVYKFFIARRDPVTM FT SGMLIPPSMGLATALNFQPTGNGRAAINGDFVMTAAEVQDVVQALRGGGIDIVAIHNHG FT FDEQPRLFYMHFWAENDAVALARTLRAAVDATAAR" FT misc_feature 16002..16034 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT repeat_region complement(16974..17096) FT /note="123 bp imperfect direct repeat 2, 92/103 bp FT identical to first copy at 709425..709548, FT AGCCCCGGCTCGACGCGGCATAGGGTGGCCACCGTGGCCGAAGCGTTCCATGCGACC FT GTGCCGTGGCGAGGATCCCGGCCGAACATGGCCCATTGAACGAGGACGTCATCGCAC FT GACGCCTGC" FT repeat_region 17111..18494 FT /mobile_element="insertion sequence:IS1536" FT /note="IS1536, len: 1384 bp. Partial copy of insertion FT sequence IS_1536." FT CDS 17133..17741 FT /transl_table=11 FT /locus_tag="Rv0605" FT /product="POSSIBLE RESOLVASE" FT /function="PREVENTS THE COINTEGRATION OF FOREIGN DNA BEFORE FT INTEGRATION INTO THE CHROMOSOME." FT /note="Rv0605, (MTCY19H5.17c), len: 202 aa. Possible FT resolvase for IS_Y349 element, similar to several FT Mycobacterial hypothetical proteins and weakly similar to FT Q52563 resolvase from Pseudomonas syringae (210 aa), FASTA FT scores: opt: 99, E(): 3.1, (35.7% identity in 98 aa FT overlap). Contains PS00397 Site-specific recombinases FT active site and probable helix-turn helix motif from aa FT 9-30 (Score 1815, +5.37 SD)." FT /db_xref="GOA:O07773" FT /db_xref="InterPro:IPR006118" FT /db_xref="InterPro:IPR006119" FT /db_xref="UniProtKB/TrEMBL:O07773" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09977.1" FT /translation="MACCRNRGMNLAAWAERNGVARVTAYRWFHAGLLPVPARKVGRLI FT LVDELASEAGAQPKTAVYARVSSADQKSDLDRQVARVTSWATAEQIPVDKVVTEVGSVL FT NGHRRKFPAVLRDLSVTRIVVEHRDRFCRFGSEYVHAALAAQGRELVVVDSAEVDDDLV FT WDMTEILTSMCARLYGKRAAQNRAKRAVAAAAVDDHEAA" FT misc_feature 17319..17345 FT /note="PS00397 Site-specific recombinases active site" FT CDS 17743..18486 FT /transl_table=11 FT /locus_tag="Rv0606" FT /product="POSSIBLE TRANSPOSASE (FRAGMENT)" FT /function="THOUGHT TO BE REQUIRED FOR THE TRANSPOSITION OF FT THE INSERTION ELEMENT IS_1536." FT /note="Rv0606, (MTCY19H5.16c), len: 247 aa. Possible FT truncated transposase for IS_1536 element, highly similar FT to N-terminus of other transposases from Mycobacterium FT tuberculosis e.g. FT YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c PUTATIVE FT TRANSPOSASE from Mycobacterium tuberculosis (460 aa), FASTA FT scores: opt: 1368, E(): 0, (83.5% identity in 237 aa FT overlap); Rv2978c, Rv0922, Rv3827c, etc. Also similar to FT N-terminus of MTV002_57|Rv2792 RESOLVASE from M. FT tuberculosis (193 aa), FASTA score: (87.4% identity in 238 FT aa overlap)." FT /db_xref="InterPro:IPR001959" FT /db_xref="UniProtKB/TrEMBL:O07772" FT /protein_id="CAB09953.1" FT /translation="MPRLEIPNGWCVQAFRFTLDPTAEQAHALARHFGARRKAYNWTVA FT QLKADIQAWRATGAQTAKPSLRVLRKRWNTVKDEVCVNAETGTVWWPECSKEAYADGIA FT GAVDAYWNWQQRRAGKRDGKRMGFPRFKKKGRDADRVSFTTGAMRVEPDRRHLTLPVIG FT CVRTHENTRRIERLIAKDRARVLAITVRRNGTRLDASVRVLVQRPQQPNVELPESRIGV FT DVGVRRLATVATADGACCPVLVPDG" FT CDS 18540..18926 FT /transl_table=11 FT /locus_tag="Rv0607" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0607, (MTCY19H5.15c), len: 128 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O07771" FT /protein_id="CAB09976.1" FT /translation="MGAWQTADTMGIFQALPDVWGGWRTECWEDRFEEQLIRCNGALRL FT PELDLAAGMDSAREWLRDRIFQRFSDSPAGQILKLSELLADVGPGLVVSDDAVTNGGAR FT PNNEEWARFVAACDLVRGAHAESA" FT CDS 18971..19216 FT /transl_table=11 FT /locus_tag="Rv0608" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0608, (MTCY19H5.14c), len: 81 aa. Conserved FT hypothetical protein, similar to several other M. FT tuberculosis hypothetical short proteins e.g. FT Rv0623|P96913|MTCY20H10.04 (84 aa), FASTA scores: opt: 159, FT E(): 1.2e-09, (43.0% identity in 86 aa overlap); Rv2760c FT (89 aa); Rv1740 (70 aa), etc." FT /db_xref="InterPro:IPR011660" FT /db_xref="UniProtKB/TrEMBL:O07770" FT /protein_id="CAB09964.1" FT /translation="MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDL FT AARLLAIGHKTASRMSPEAKRLDHDALLYDERGLPA" FT CDS 19213..19614 FT /transl_table=11 FT /locus_tag="Rv0609" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0609, (MTCY19H5.13c), len: 133 aa. Conserved FT hypothetical protein, similar to several Mycobacterium FT tuberculosis hypothetical proteins e.g. FT YW37_MYCTU|Q10874|Rv1982c|MT2034|MTCY39.37 CONSERVED FT HYPOTHETICAL PROTEIN (139 aa), FASTA scores: opt: 262, E(): FT 8.1e-12, (39.1% identity in 128 aa overlap); FT MTCY20H10.05|Rv0624|MT0652|MTCY20H10.05 CONSERVED FT HYPOTHETICAL PROTEIN (131 aa), FASTA score: (42.9% identity FT in 126 aa overlap), Rv0565c, Rv3854c, etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/Swiss-Prot:P67238" FT /protein_id="CAB09975.1" FT /translation="MIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVL FT DSQRDPVISRALDELIEEAEFVVEPVTERQARLARAAYADFGRGSGHPAGLNFGDCLSY FT ALAIDRREPLLWKGNDFGHTGVQRALDRR" FT CDS 19557..19784 FT /transl_table=11 FT /locus_tag="Rv0609A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0609A, len: 75 aa. Conserved hypothetical protein, FT highly similar to part of upstream ORF Rv0612|MTCY19H5.09c FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (201 aa), FASTA scores: opt: 154, E(): FT 1.8e-05, (74.3% identity in 35 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q79FY5" FT /protein_id="CAE55303.1" FT /translation="MEGQRLWAHRRPKGTGSAVIDVSLARRCEAHGYDYFRSDDPVAAA FT GFVVSAVWSCGRGPGNATGSGRLPKPLRHS" FT repeat_region complement(19639..19712) FT /note="74 bp imperfect direct repeat 2, 64/73 bp identical FT to first copy at 706790..706863, FT CACAGCGGACACCACAAAGCCCGCCGCTGCCACCGGATCGTCGGAACGAAAATAGTC FT GTACCCGTGAGCCTCGC" FT CDS complement(20479..21636) FT /transl_table=11 FT /locus_tag="Rv0610c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0610c, (MTCY19H5.11), len: 385 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O07767" FT /protein_id="CAB09963.1" FT /translation="MDDELRGLLARYARGELSADDARRAILRYPKWRVAEIDGELETVA FT LDDGTPMLIAESSASDGREYSGLELVRDIAPLVGGLSFDPDEPWGSAFRPGALPELQNW FT ARTVELEDAVAKPGPGQRDLLYEGPWWVAVSPGTGRPAVHRADGLDVITIMTAPDAAAT FT FRRTERHRGLDVVRLGPALWGDLAKRSDFDGVRLNPLRPLAQLWPPHVPAMLVAGCDPR FT PNAEPLPARTVAEIHLWLDQHGARQEKRELSNRATPVGEVTVARAWWNYDRREIAFTRV FT APASDTEGLGSVPSRILCAGKLRQSIQSKLAGLPRLTWRADAWHRQRAALAVGWALELE FT KLVCGERVPFAALRTPEGAHLWHLEPQAFTARAIRKLRDRAASFR" FT CDS complement(21688..22071) FT /transl_table=11 FT /locus_tag="Rv0611c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0611c, (MTCY19H5.10), len: 127 aa. Hypothetical FT unknown protein. Note that first start has been taken FT although this overlaps slightly with the upstream ORF." FT /db_xref="UniProtKB/TrEMBL:O07766" FT /protein_id="CAB09974.1" FT /translation="MPDRPQHPTASRQSSMVSWNHGAAGWLHCVQCGSATNPTACLDWL FT PPIHARSGPMYAEHDVVVLTRDVPDKSLIAGDVGAVVGRYAAGGYEVDFTAANGCTVAV FT VTLAGDDIRPRRRREIPHVREVA" FT CDS 22051..22656 FT /transl_table=11 FT /locus_tag="Rv0612" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0612, (MTCY19H5.09c), len: 201 aa. Conserved FT hypothetical protein, highly similar, but in part, to FT downstream ORF Rv0609A CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (75 aa); and showing weak FT similarity with other hypothetical proteins from FT Mycobacterium tuberculosis. Note that first start has been FT taken although this overlaps slightly with the upstream FT ORF." FT /db_xref="UniProtKB/TrEMBL:O07765" FT /protein_id="CAB09973.1" FT /translation="MLGPIRQPRLTVRPGRLPGMIAGVAAKRMNREQFFRAASGLDEDR FT LRKALWNLYWRGTANMRERIEAELASAGRARPARKIKPPADPDIVGWEVDEFVSLARSG FT AYLGGDRRVSPRERSRWRFTFKRLAAEAQDALRAEDAEPAASALEQLIDLAREADGYDY FT FRSDDPVAAAGFVVSDVAAAGHPHFREFAAEIGAAIPP" FT repeat_region complement(22517..22590) FT /note="74 bp imperfect direct repeat 1, 64/73 bp identical FT to second copy at 703912..703985, FT CACATCGGACACGACGAAACCCGCCGCTGCCACCGGATCGTCGGAGCGGAAGTAGTC FT GTACCCGTCGGCCTCGC" FT CDS complement(22675..25242) FT /transl_table=11 FT /locus_tag="Rv0613c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0613c, (MTCY19H5.08), len: 855 aa. Hypothetical FT unknown protein. Contains a very short region with strong FT similarity to several preprotein translocases e.g. FT P47847|SECA_LISMO preprotein translocase seca subunit (836 FT aa), FASTA scores: opt: 138, E(): 0.18, (38.6% identity in FT 70 aa overlap, and 72.7% identity in 22 aa overlap)." FT /db_xref="InterPro:IPR004027" FT /db_xref="UniProtKB/TrEMBL:O07764" FT /protein_id="CAB09972.1" FT /translation="MAEAFDATQAVARILAEHGPLSEDDIARRLLDSGVADPDAVLRAL FT RLETEWPARQLVDDRWVWLPTLLAGRVFTHRLGADEAVHDMLGVTPDLDPITTLCEHEE FT YGRLADGSAARIVLAGYDEELLERRGIPDEAIDPGGALLLEPGTLATLGAAAGDLVGVR FT LTAAGLVLERIGTAGADTSVGARLAELVDPDEPAFFPAAVWTACVDDPAAFTEPVAPLR FT EILDQHGLTHEDDWLAPGGFNFDAWRFENRCELLAFRHDLDPNDAVALYTLIKLHETMS FT LLLEATDPDELPRDVLATAAETATETGSDSLVDLLGDIGAALADPLLAELLVAETVGTD FT SGGAAALGLLTEMLEPKVPRAARVAVRWLRAVALDRIGDVEAAERELLAAESMDTEWPL FT PLLDLARIASDRGDAERGLALLRRAGTEPDHPLVRLLERHRAQPRRDLGRNEACWCGSG FT RKYKKCHLGREALPLAERVDWLYAKASQHALSGDWTGLLAEVSYERFRYADSDDEDALA FT AALADPLVLDAVLFEGGAFAEFLEVRGSLLPDDERLLAEQWLLVERSVFEVEHVQPGEG FT VIVRDVRTGDTHEVHERAASRQLRAGQLICARPVPAGDTMVFFGGIEPVALHERAVLIE FT LLDDEPDPVTLVAQLSRRFAPPTLVNTEGDSLAICEASVRVDDPAGIQGALDGVYDRVD FT GEEPPRWIEHVTNDGMLRVRATLVLDGDTLRVETNSEPRMDRVLATLTRLDPAMTVLDD FT DRRPLRNTREAAALAEQMPVTGAGAPDPDSPELAAALEEFIRDYETSWLDQPIPALDGH FT TPRQAADDPTRRADLIKLLDTFPAGAGARGGMDADRLRTALGL" FT CDS 25083..26075 FT /transl_table=11 FT /locus_tag="Rv0614" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0614, (MTCY19H5.07c), len: 330 aa. Conserved FT hypothetical protein, similar in part to Mycobacterium FT tuberculosis hypothetical proteins e.g. FT YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c CONSERVED FT HYPOTHETICAL PROTEIN (323 aa), FASTA scores: opt: 200, E(): FT 0.00016, (28.3% identity in 269 aa overlap); MTCY9F9_15 FT FASTA score: (40.3% identity in 144 aa overlap), Rv1949c, FT Rv2542, etc. Several start sites are possible; first start FT has been chosen. Note that this ORF overlaps with the FT upstream ORF." FT /db_xref="UniProtKB/TrEMBL:O07763" FT /protein_id="CAB09971.1" FT /translation="MPAIPFQGEARAGRRPGRPRRCPAGVVRCRPRSMGHVRPGFSPRL FT GSHRTLRPRWPPYAAASRGLTSGTSRWGWPRLGFGVVTAPTRWTLADGRELLFFSLPGP FT RTSGTAAERVARHAQAQTFAGDIRQRAIQLVVSEQEVASKITAATAGIATTTFPETPSI FT DDTIIGNDNRDTGVRLVDVKQDGGTSPPPPFAPWDTPDGTPPPGTGLSPTLQQMILGGD FT PANLTGQGLADNVQRFVQSLPANDPNTAWLRGQVADLQAHVADIEYARTHCSTNDWIDR FT TAQFASGAIVFSIGVLTAETGAGVVAAAAGGVGAATAGVSLLQCLVGSK" FT repeat_region complement(25152..25275) FT /note="123 bp imperfect direct repeat 1, 92/103 bp FT identical to second copy at 701247..701369, FT AGCCTCGGCTGGCCGCGGCATAAGGTGGCCACCGTGGCCGAAGCGTTCGATGCGACC FT CAAGCCGTGGCGAGAATCCTGGCCGAACATGGCCCATTGAGCGAGGACGACATCGCA FT CGACGCCTGC" FT repeat_region 25312..25390 FT /note="79 bp imperfect direct repeat 1, 73/78 bp identical FT to second copy at 711624..711702, FT TAGGGTTCGGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGACGGACGTGAGC FT TGCTGTTCTTTTCGCTGCCCGG" FT CDS 26072..26314 FT /transl_table=11 FT /locus_tag="Rv0615" FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0615, (MTCY19H5.06c), len: 80 aa. Probable FT integral membrane protein." FT /db_xref="UniProtKB/TrEMBL:O07762" FT /protein_id="CAB09970.1" FT /translation="MMDVLAAGIAAGALTLAAWGAWRPHYRAASYLVAGAVELALIGLL FT VVTGQTLMAISVAFLVALGGPLVVVNHRRAERSRG" FT CDS complement(26311..26577) FT /transl_table=11 FT /locus_tag="Rv0616c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0616c, (MTCY19H5.05), len: 88 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O07761" FT /protein_id="CAB09969.1" FT /translation="MRIPGNRQCLLVQVLRQVDGSAHRLILTSLHRDARADAHRYSNGT FT DHAGRAADEPAETAHEPCWVAARGLASQASRAMSATYRPSSFI" FT CDS 26733..27134 FT /transl_table=11 FT /locus_tag="Rv0617" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0617, (MTCY19H5.04c), len: 133 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv2494, Rv3320c, Rv0749, FT Rv0277c, Rv2530c, etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="InterPro:IPR006226" FT /db_xref="UniProtKB/TrEMBL:O07760" FT /protein_id="CAB09968.1" FT /translation="MTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSL FT VRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALSFAGVEVAGVVGHRQVTDAYLAQLA FT RSHDGQLATLDSGLAHLHGDVAVLIPTTT" FT CDS 27263..27958 FT /transl_table=11 FT /gene="galTa" FT /locus_tag="Rv0618" FT /standard_name="galT'" FT /product="PROBABLE GALACTOSE-1-PHOSPHATE FT URIDYLYLTRANSFERASE GALTA [FIRST PART]" FT /function="INVOLVED IN GALACTOSE METABOLISM (LELOIR FT PATHWAY) [CATALYTIC ACTIVITY: UTP + alpha-D-galactose FT 1-phosphate = diphosphate + UDP-galactose]." FT /EC_number="2.7.7.10" FT /note="Rv0618, (MTCY19H5.03c), len: 231 aa (probable FT partial CDS). Probable galTa, first part of FT galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), FT highly similar to N-terminal half of other galT proteins FT e.g. P13212|GAL7_STRLI galactose-1-phosphate FT uridylyltransferase from Streptomyces lividans (354 aa), FT FASTA scores: opt: 296, E(): 1.4e-11, (50.8% identity in FT 177 aa overlap); etc. Also highly similar to N-terminal FT half of some UDP glucose--hexose-1-phosphate FT uridylyltransferases (EC 2.7.7.12). N-terminal 28 aa FT similar to MTCY20H11.08|Rv0627|MTCY20H11.08 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 FT aa), FASTA score: (71.4% identity in 28 overlap). Cosmid FT sequence is correct but there may be a frameshift mutation FT in this region which would allow the two ORFs to be joined. FT BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FT FAMILY 1. Note that previously known as galT'." FT /db_xref="GOA:Q79FY4" FT /db_xref="InterPro:IPR001937" FT /db_xref="InterPro:IPR005849" FT /db_xref="InterPro:IPR011146" FT /db_xref="InterPro:IPR011151" FT /db_xref="UniProtKB/TrEMBL:Q79FY4" FT /protein_id="CAE55304.1" FT /translation="MSATPPPGGLDASVFIANERGRQLDEALPVGFCVVTAPTRWTLAD FT GRDLLFFSLPGHVPAPVSDRRPLPERDPAPSRLRFDRATGQWVIVAAQRQDRTYKPPAA FT RCPLCPGPTGLSSEVPAPDYDVVVFENRFPSLAGAGIAPIGAPDGDGFVSAPGHGRCEV FT ICFSADHTGSFAGLDPAHARLVVHAWRHRTAELTALPGVAQVFCFENRGEEIGVTLPTR FT TARFTPIRI" FT repeat_region 27351..27429 FT /note="79 bp imperfect direct repeat 2, 73/78 bp identical FT to first copy at 709585..709663, FT TAGGGTTCTGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGATGGCCGTGACC FT TGCTGTTCTTTTCGCTGCCCGG" FT CDS <27901..28446 FT /transl_table=11 FT /gene="galTb" FT /locus_tag="Rv0619" FT /standard_name="'galT" FT /product="PROBABLE GALACTOSE-1-PHOSPHATE FT URIDYLYLTRANSFERASE GALTB [SECOND PART]" FT /function="INVOLVED IN GALACTOSE METABOLISM (LELOIR FT PATHWAY) [CATALYTIC ACTIVITY: UTP + alpha-D-galactose FT 1-phosphate = diphosphate + UDP-galactose]." FT /EC_number="2.7.7.10" FT /note="Rv0619, (MTCY19H5.02c), len: 181 aa (probable FT partial CDS). Probable galTb, second part of FT galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), FT highly similar to C-terminal half of other galT proteins FT e.g. P13212|GAL7_STRLI galactose-1-phosphate FT uridylyltransferase from Streptomyces lividans (354 aa), FT FASTA scores: opt: 416, E(): 5.2e-22, (43.0% identity in FT 186 aa overlap), etc. Cosmid sequence is correct but there FT may be a frameshift mutation in this region which would FT allow the two ORFS to be joined. BELONGS TO THE FT GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FAMILY 1. Note FT that previously known as 'galT." FT /db_xref="GOA:Q79FY3" FT /db_xref="InterPro:IPR001937" FT /db_xref="InterPro:IPR005850" FT /db_xref="InterPro:IPR011146" FT /db_xref="InterPro:IPR011151" FT /db_xref="UniProtKB/TrEMBL:Q79FY3" FT /protein_id="CAE55305.1" FT /translation="GDRGDPAHPHGQIYAYPYLTPRTAAMLRQARRHRKRHGDNLFASL FT LAREVADGSRIVVRGELFTAFVPFAARWPVEVHIYPNRLVRNLTELNDGELDEFARIYL FT DVLQRFDRMYSSPLPYMSALHQFSEVQRDGYFHVELMSIRRSATKLKYLAAAESAMDAF FT IADVIPESVATRLRELGP" FT CDS 28443..29534 FT /transl_table=11 FT /gene="galK" FT /locus_tag="Rv0620" FT /product="PROBABLE GALACTOKINASE GALK (GALACTOSE KINASE)" FT /function="INVOLVED IN GALACTOSE METABOLISM (LELOIR FT PATHWAY) (AT THE FIRST REACTION) [CATALYTIC ACTIVITY: ATP + FT D-galactose = ADP + D-galactose 1-phosphate]." FT /EC_number="2.7.1.6" FT /note="Rv0620, (MTCY19H5.01c, MTCY20H10.01), len: 363 aa. FT Probable galK, galactokinase (EC 2.7.1.6), similar to FT others e.g. P13227|GAL1_STRLI GALACTOKINASE from FT Streptomyces lividans (397 aa); P06976|GAL1_ECOLI FT galactokinase from Escherichia coli (381 aa), FASTA scores: FT opt: 669, E(): 0, (35.9% identity in 365 aa overlap); etc. FT Contains PS00106 Galactokinase signature and PS00560 Serine FT carboxypeptidases, histidine active site. BELONGS TO THE FT GHMP KINASE FAMILY. GALK SUBFAMILY." FT /db_xref="GOA:P96910" FT /db_xref="InterPro:IPR000705" FT /db_xref="InterPro:IPR006204" FT /db_xref="InterPro:IPR006206" FT /db_xref="InterPro:IPR013750" FT /db_xref="InterPro:IPR014721" FT /db_xref="InterPro:IPR019539" FT /db_xref="InterPro:IPR019741" FT /db_xref="InterPro:IPR020568" FT /db_xref="UniProtKB/Swiss-Prot:P96910" FT /protein_id="CAB09965.1" FT /translation="MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGA FT ITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEIGS FT GLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPK FT TALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVS FT SLRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHE FT SMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVIALVPADRARDVADTVRRAA FT VTAGYDEPAVSRTYAAPGAAECR" FT misc_feature 28467..28502 FT /note="PS00106 Galactokinase signature" FT misc_feature 28686..28712 FT /note="PS00560 Serine carboxypeptidases, histidine active FT site" FT CDS 29929..30993 FT /transl_table=11 FT /locus_tag="Rv0621" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0621, (MTCY20H10.02), len: 354 aa. Possible FT membrane protein; contains potential membrane spanning FT regions. Also contains PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="UniProtKB/TrEMBL:P96911" FT /protein_id="CAB07110.1" FT /translation="MAGDRGADPGPANVTPGADDHAQHASPTVLCPQGHVNAWDYRFCE FT RCGSPIGVVPWPSEESGTRQTAPARSFVPLVVLAATLLVVAVVVTAVGYAVTRPARNDR FT EEPSSARGAATTGVPFAQAEAASCPDDPVLEAESIDLTSDGLAVSAAFMSACAGGDVES FT NSALEVTVADGRRDVAAGSFDFSADPLRIEPGVPARRTLVFPPGMYWRTPDMLSGAPAL FT AATRKGRSDRSAARGGSARTTMVAAASAAPAYGSINAVAGAVLVELRDSDFPYVRVGIA FT NRWVPQVSSKRVGLVAAGKTWTSADILRDHLALRQRFGGARLVWSGHWTTFSGPDFWVT FT VVGPAQPTAAEANR" FT misc_feature 30808..30831 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 31097..32044 FT /transl_table=11 FT /locus_tag="Rv0622" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0622, (MTCY20H10.03), len: 315 aa. Possible FT membrane protein; contains potential membrane spanning FT region. Shows weak similarity with Mycobacterium FT tuberculosis hypothetical proteins Rv1804c, Rv1810, etc. FT Start changed since first submission (-26 aa)." FT /db_xref="UniProtKB/TrEMBL:P96912" FT /protein_id="CAB07111.2" FT /translation="MSFCVYCGAELADPTRCGACGAYKIGSTWHRTTTPTVGAATTATG FT WRPDPTGRHEGRYFVAGQPTDLVREGDAEAVDPLGQQQLDQSGAVGVSPSAVSGWVRSG FT HRRLWWALAGVVAFLGLVGAGVVGTLFLNRDRESIDDKYLAALRRSGLTGEFNSDANAI FT ARGKQVCRQLQDGGEQQGMPVDQVAVQYYCPQFSDGFHILETITVTGSFTLKDESPNVY FT APAITVSGSGCSGSAGYADIDRGTQVTVKNGQGDILATAFLQAGQGGRFLCTFPFSFEI FT TEGEDRYVVSVSRRGEMSYSFADLKANGLSLVLG" FT CDS 32137..32391 FT /transl_table=11 FT /locus_tag="Rv0623" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0623, (MTCY20H10.04), len: 84 aa. Conserved FT hypothetical protein, highly similar to FT NP_384911.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from FT Sinorhizobium meliloti (84 aa). Also similar to several FT Mycobacterium tuberculosis hypothetical proteins e.g FT MTCY28_2|Rv1740|MTCY28.02|MTCY04C12.25 CONSERVED FT HYPOTHETICAL PROTEIN (70 aa), FASTA score: (73.5% identity FT in 68 aa overlap); MTCY4C12_25|Rv0608|MTCY19H5.14c FT CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA score: (73.5 FT identity in 68 aa overlap); etc." FT /db_xref="InterPro:IPR011660" FT /db_xref="UniProtKB/TrEMBL:P96913" FT /protein_id="CAB07112.1" FT /translation="MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRAR FT VVPLRDELAAIRHRCAALPVVDNRSAEAILGYDERGLPA" FT CDS 32391..32786 FT /transl_table=11 FT /locus_tag="Rv0624" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0624, (MTCY20H10.05), len: 131 aa. Conserved FT hypothetical protein, highly similar to Mycobacterium FT tuberculosis hypothetical proteins e.g. Rv1741, Rv0609, FT Rv2759c,Rv0565c, Rv3854c, Rv3083, etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/Swiss-Prot:P67240" FT /protein_id="CAB07113.1" FT /translation="MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVI FT EARFGEPGGRELDLWLHRAAVDLVAVHADQADAARAAYRTYGKGRHRAGLNYGDCFSYG FT LAKISGQPLLFKGEDFQHTDIATVALP" FT CDS complement(32880..33620) FT /transl_table=11 FT /locus_tag="Rv0625c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0625c, (MTCY20H10.06c), len: 246 aa. Probable FT conserved transmembrane protein, showing similarity with FT others e.g. CAB61866.1|AL133252 putative integral membrane FT protein from Streptomyces coelicolor (249 aa). Also similar FT to Rv1491c|MTCY277_13 from Mycobacterium tuberculosis. FT Contains potential membrane spanning regions." FT /db_xref="GOA:P67115" FT /db_xref="InterPro:IPR015414" FT /db_xref="UniProtKB/Swiss-Prot:P67115" FT /protein_id="CAB07114.1" FT /translation="MSTHNDSAPTSRRRHIVRLVVFAGFLVGMFYLVAATDVIDVAAVR FT GAVSATGPAAPLTYVVVSAVLGALFVPGPILAASSGLLFGPLVGVFVTLGATVGTAVVA FT SLVGRRAGRASARALLGGERADRTDALIERCGLWAVVGQRFVPGISDAFASYAFGTFGV FT PLWQMAVGAFIGSAPRAFAYTALGAAIGDRSPLLASCAIAVWCVTAIIGAFAARHGYRQ FT WRAHARGDGADGGVEDPDREVGAR" FT CDS 33752..34012 FT /transl_table=11 FT /locus_tag="Rv0626" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0626, (MTCY20H10.07), len: 86 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv0596c, Rv3385c, FT Rv3407,Rv3181c, etc." FT /db_xref="InterPro:IPR003756" FT /db_xref="InterPro:IPR006442" FT /db_xref="PDB:3DBO" FT /db_xref="UniProtKB/TrEMBL:P96916" FT /protein_id="CAB07115.1" FT /translation="MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRR FT RRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTEDLGPIR" FT CDS 34009..34416 FT /transl_table=11 FT /locus_tag="Rv0627" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0627, (MTCY20H11.08), len: 135 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical proteins Rv0595c and Rv0665." FT /db_xref="InterPro:IPR002716" FT /db_xref="PDB:3DBO" FT /db_xref="UniProtKB/TrEMBL:P96917" FT /protein_id="CAB07116.1" FT /translation="MSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRV FT GVLAAATTDIRAQRLATLESVADMETLPVDDDAARMWARLRIHLAESGRRVRINDLWIA FT AVAASRALPVITQDDDFAALDGAASVEIIRV" FT CDS complement(34488..35639) FT /transl_table=11 FT /locus_tag="Rv0628c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0628c, (MTCY20H10.09c), len: 383 aa. Conserved FT hypothetical protein, highly similar to FT Rv0874c|YZ02_MYCTU|Q10536 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (386 aa), FASTA scores: FT opt: 2082, E(): 0, (81.5% identity in 383 aa overlap). Also FT some similarity to P72543|SPU62616_1 HYPOTHETICAL PROTEIN FT from Synechococcus, FASTA scores: E(): 2.8e-28, (36.6 FT identity in 265 aa overlap)." FT /db_xref="GOA:P64729" FT /db_xref="InterPro:IPR013702" FT /db_xref="InterPro:IPR016741" FT /db_xref="InterPro:IPR019494" FT /db_xref="UniProtKB/Swiss-Prot:P64729" FT /protein_id="CAB07117.1" FT /translation="MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSHT FT DQAVDLLAAVQASVEPAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDFVR FT TGSGALITGYRFDRTAHDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGRRRG FT DTRLFRDRDVLTSGLVGVRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGGRPPL FT HRLREIVLGMAPDEQELVSRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGAIGIGE FT VVEVGATVQFQVRDAAAADKDLRLAVERAAAELPGPPVGGLLFTCNGRGRRMFGVTDHD FT ASTIEDLLGGIPLAGFFAAGEIGPVAGHNALHGFTASMALFVD" FT CDS complement(35732..37459) FT /transl_table=11 FT /gene="recD" FT /locus_tag="Rv0629c" FT /product="PROBABLE EXONUCLEASE V (ALPHA CHAIN) RECD FT (EXODEOXYRIBONUCLEASE V ALPHA CHAIN) (EXODEOXYRIBONUCLEASE FT V POLYPEPTIDE)" FT /function="INVOLVED IN HOMOLOGOUS RECOMBINATION." FT /EC_number="3.1.11.5" FT /note="Rv0629c, (MTCY20H10.10c), len: 575 aa. Probable FT recD, exonuclease V, alpha chain (exodeoxyribonuclease V, FT alpha chain) (EC 3.1.11.5) (see citation below), highly FT similar to other exonucleases e.g. FT AF157643_3|AAD46809.1|recD Escherichia coli RecD protein FT homolog from Mycobacterium smegmatis (554 aa); FT P04993|EX5A_ECOLI|B2819 exodeoxyribonuclease v 67kd FT polypeptide (EC 3.1.11.5) (EXONUCLEASE V ALPHA CHAIN) from FT Escherichia coli strain K12 (608 aa), FASTA scores: opt: FT 512, E(): 1.9e-24, (36.9% identity in 582 aa overlap); etc. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT CONSIST OF THREE SUBUNITS; RECB|Rv0630c, RECC|Rv0631c AND FT RECD." FT /db_xref="GOA:P96919" FT /db_xref="InterPro:IPR006344" FT /db_xref="UniProtKB/TrEMBL:P96919" FT /protein_id="CAB07118.1" FT /translation="MKLTDVDFAVEASGMVRAFNQAGVLDVSDVHVAQRLCALAGESDE FT RVALAVAVAVRALRAGSVCVDLLSIARVAGHDDLPWPDPADWLAAVRASPLLADPPVLH FT LYDDRLLYLDRYWREEEQVCADLLALLTSRRPAGVPDLRRLFPTGFDEQRRAAEIALSQ FT GVTVLTGGPGTGKTTTVARLLALVAEQAELAGEPRPRIALAAPTGKAAARLAEAVRREM FT AKLDATDRARLGDLHAVTLHRLLGAKPGARFRQDRQNRLPHNVIVVDETSMVSLTLMAR FT LAEAVRPGARLILVGDADQLASVEAGAVLADLVDGFSVRDDALVAQLRTSHRFGKVIGT FT LAEAIRAGDGDAVLGLLRSGEERIEFVDDEDPAPRLRAVLVPHALRLREAALLGASDVA FT LATLDEHRLLCAHRDGPTGVLHWNRRVQAWLAEETGQPPWTPWYAGRPLLVTANDYGLR FT VYNGDTGVVLAGPTGLRAVISGASGPLDVATGRLGDVETMHAMTIHKSQGSQVDEVTVL FT MPQEDSRLLTRELLYTAVTRAKRKVRVVGSEASVRAAIARRAVRASGLRMRLQSTGCG" FT misc_feature complement(36929..36952) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(37456..40740) FT /transl_table=11 FT /gene="recB" FT /locus_tag="Rv0630c" FT /product="PROBABLE EXONUCLEASE V (BETA CHAIN) RECB FT (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V FT POLYPEPTIDE) (CHI-SPECIFIC ENDONUCLEASE)" FT /function="INVOLVED IN HOMOLOGOUS RECOMBINATION." FT /EC_number="3.1.11.5" FT /note="Rv0630c, (MTCY20H10.11c), len: 1094 aa. Probable FT recB, exonuclease V, beta chain (exodeoxyribonuclease V, FT beta chain) (EC 3.1.11.5) (see citation below), highly FT similar to other exonucleases e.g. FT AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein FT homolog from Mycobacterium smegmatis (1083 aa); FT P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kDa FT polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from FT Escherichia coli strain K12 (1180 aa), FASTA scores: opt: FT 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF FT THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c." FT /db_xref="GOA:P96920" FT /db_xref="InterPro:IPR000212" FT /db_xref="InterPro:IPR004586" FT /db_xref="InterPro:IPR011604" FT /db_xref="InterPro:IPR014016" FT /db_xref="InterPro:IPR014017" FT /db_xref="UniProtKB/Swiss-Prot:P96920" FT /protein_id="CAB07119.1" FT /translation="MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAAT FT LDEMLLITFNRAASRELRERVRGQIVEAVGALQGDAPPSGELVEHLLRGSDAERAQKRS FT RLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADVELKESLTDLVTEIVDDRYLAN FT FGRQETDPELTYAEALALALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEELERRK FT GRLRAQGFNDLLIRLATALEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSR FT HSALILIGDPKQAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDA FT TLGHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEALRRHIPD FT DLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNALAEAGIPAIYTGDTDVF FT ASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFGETAESLAAEGDALTDRVAGTLREWA FT DHARHRGVAAVFQAAQLAGMGRRVLSQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLR FT DWLRRQAKAGAGPPEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDIL FT LYHDDGTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRAQSQVVAWWAPTF FT DEVNGGLSRLLRGRRPGQSQVPDRCTPRVTDEQAWAVFAQWEAAGGPSVEESVIGARSS FT LEKPVPVPGFEVRHFHRRIDTTWRRTSYSDLVRGSEAVTVTSEPAAGGRADEVEIAVVA FT APGSGADLTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVRRHAPWWTVDVD FT HAQLAPELARALLPMHDTPLGPAAAALTLRQIGVRDRLRELDFEMPLAGGDLRGRSPDV FT SLADVGELLASHLPGDDPLSPYADRLGSAGLGDQPLRGYLAGSIDVVLRLPGQRYLVVD FT YKTNHLGDTAADYGFERLTEAMLHSDYPLQALLYVVVLHRFLRWRQRDYAPARHLGGVL FT YLFVRGMCGAATPVTAGHPAGVFTWNPPTALVVALSDLLDRGRLQS" FT misc_feature complement(40657..40680) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(40740..44033) FT /transl_table=11 FT /gene="recC" FT /locus_tag="Rv0631c" FT /product="PROBABLE EXONUCLEASE V (GAMMA CHAIN) RECC FT (EXODEOXYRIBONUCLEASE V GAMMA CHAIN)(EXODEOXYRIBONUCLEASE V FT POLYPEPTIDE)" FT /function="INVOLVED IN HOMOLOGOUS RECOMBINATION." FT /EC_number="3.1.11.5" FT /note="Rv0631c, (MTCY20H10.12c), len: 1097 aa. Probable FT recC, exonuclease V, gamma chain (exodeoxyribonuclease V, FT gamma chain) (EC 3.1.11.5) (see Mizrahi & Andersen 1998), FT highly similar to other exonucleases e.g. FT AF157643_1|RecC|AAD46807.1 Escherichia coli RecC protein FT homolog from Mycobacterium smegmatis (1085 aa); FT P07648|EX5C_ECOLI|B2822 exodeoxyribonuclease v 125 kDa FT polypeptide (EC 3.1.11.5) (EXONUCLEASE V GAMMA CHAIN) from FT Escherichia coli strain K12 (1122 aa), FASTA scores: opt: FT 954, E(): 0, (29.2% identity in 1109 aa overlap); etc. FT CONSIST OF THREE SUBUNITS; RECB|Rv0630c, RECC AND FT RECD|Rv0629c. The transcription of this CDS seems to be FT activated specifically in host granulomas (see Ramakrishnan FT et al., 2000)." FT /db_xref="GOA:P96921" FT /db_xref="InterPro:IPR006697" FT /db_xref="UniProtKB/Swiss-Prot:P96921" FT /protein_id="CAB07120.1" FT /translation="MALHLHRAERTDLLADGLGALLADPQPDPFAQELVLVAARGVERW FT LSQRLSLVLGCGPGRADGVCAGIAFRNPQSLIAEITGTLDDDPWSPEALAWPLLAVIDA FT SLDEPWCRTLASHLGHFATTDAEAELRRGRRYSVARRLAGLFASYARQRPGLLAAWLDG FT DLGELPGDLAWQPPLWRALVTTVGADPPHVRHDKTIARLRDGPADLPARLSLFGHTRLA FT CTDVQLLDALAVHHDLHLWLPHPSDELWRALAGFQGADGLLPRRQDTSRRAAQHPLLET FT LGRDVRELQRALPAARATDEFLGATTKPDTLLGWLQADIAGNAPRPAGRSLSDADRSVQ FT VHACHGPARQIDVLREVLLGLLEDDPTLQPRDIVVMCPDIDTYAPLIVAGFGLGEVAGD FT CHPAHRLRVRLADRALTQTNPLLSVAAELLTIAETRATASQLLNLAQAAPVRAKFGFAD FT DDLDTITTWVRESNIRWGFDPTHRRRYGLDTVVHNTWRFGLDRILTGVAMSEDSQAWLD FT TALPLDDVGSNRVELAGRLAEFVERLHHVVGGLSGARPLVAWLDALATGIDLLTACNDG FT WQRAQVQREFADVLARAGSRAAPLLRLPDVRALLDAQLAGRPTRANFRTGTLTVCTMVP FT MRSVPHRVVCLVGLDDGVFPRLSHPDGDDVLAREPMTGERDIRSEDRQLLLDAIGAATQ FT TLVITYTGADERTGQPRPPAVPLAELLDALDQTTSAPVRERILVTHPLQPFDRKNVTPG FT ALLGAKPFTFDPAALAAAQAAAGKRCPPTAFISGRLPAPPAADVTLADLLDFFKDPVKG FT FFRALDYTLPWDVDTVEDSIPVQVDALAEWTVGERMLRDMLRGLHPDDAAHSEWRRGTL FT PPGRLGVRRAKEIRNRARDLAAAALAHRDGHGQAHDVDVDLGDGRRLSGTVTPVFGGRT FT VSVTYSKLAPKHVLPAWIGLVTLAAQEPGREWSALCIGRSKTRNHIARRLFVPPPDPVA FT VLRELVLLYDAGRREPLPLPLKTSCAWAQARRDGQDPYPPARECWQTNRFRPGDDDAPA FT HVRAWGPRAPFEVLLGKPRAGEEVAGEETRLGALAARLWLPLLAAEGSV" FT CDS complement(44310..45005) FT /transl_table=11 FT /gene="echA3" FT /locus_tag="Rv0632c" FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA3 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv0632c, (MTCY20H10.13c), len: 231 aa. Probable FT echA3, enoyl-CoA hydratase (EC 4.2.1.17), almost identical FT to the MTU88877_1 enoyl-CoA hydratase of Mycobacterium FT tuberculosis field isolate NTI64719, FASTA score: (92.4% FT identity in 184 aa overlap). Also similar to others e.g. FT P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter FT capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA FT scores: opt: 206, E(): 6.3e-07, (31.5% identity in 232 aa FT overlap); etc." FT /db_xref="GOA:P96907" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:P96907" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07121.1" FT /translation="MSDPVSYTRKDSIAVISMDDGKVNALGPAMQQALNAAIDNADRDD FT VGALVITGNGRVFSGGFDLKILTSGEVQPAIDMLRGGFELAYRLLSYPKPVVMACTGHA FT IAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYAALEIMKLRLTRSAYQQATGLAKT FT FFGETALAAGFIDEIALPEVVVSRAEEAAREFAGLNQHAHAATKLRSRADALTAIRAGI FT DGIAAEFGL" FT CDS complement(45054..45893) FT /transl_table=11 FT /locus_tag="Rv0633c" FT /product="POSSIBLE EXPORTED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0633c, (MTCY20H11.14c), len: 279 aa. Possible FT exported protein; has hydrophobic stretch at aa 23-41." FT /db_xref="UniProtKB/TrEMBL:P96923" FT /protein_id="CAB07122.1" FT /translation="MVDSMGWVLSSWHEVTGVDSGTWLAWAAWAALGLGVVALVVTKRQ FT IQRNRRLAAEQTRPYVAMFMEPHVADWHVIELVVRNFGRTAAYDVRFSFPNPPTVAQYE FT NAANGYADVVELRLPQELPMLAPGQEWRMVWDSALDRAEIGRGIESRFPGTVTYYDRPE FT QPRRWRFWRRGRRPLETKVVLDWDALPPVARIELMTTHDLAKREKQKLELLRSLLTYFH FT YASKETRPDVFRSEIDRINRAAAETQDRWRARQVEVPTEVSQRSEGQGPQPTRIPAG" FT CDS complement(46047..46760) FT /transl_table=11 FT /locus_tag="Rv0634c" FT /product="POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE FT HYDROLASE) (GLX II)" FT /function="THOUGHT TO BE INVOLVED IN GLYOXAL PATHWAY. FT THIOLESTERASE THAT CATALYSES THE HYDROLYSIS OF FT S-D-LACTOYL-GLUTATHIONE TO FORM GLUTATHIONE AND D-LACTIC FT ACID [CATALYTIC ACTIVITY: (S)-(2-hydroxyacyl)glutathione + FT H2O = glutathione + a 2-hydroxy acid anion]." FT /EC_number="3.1.2.6" FT /note="Rv0634c, (MTCY20H10.15c), len: 237 aa. Possible FT glyoxalase II (EC 3.1.2.6), equivalent to FT NP_302290.1|NC_002677 putative glyoxylase II from FT Mycobacterium leprae (238 aa); and similar to FT U00011_3|Y0BK_MYCLE|Q49649 hypothetical 23.9 kDa protein FT from Mycobacterium leprae (218 aa), FASTA scores: opt: 281, FT E(): 3.9e-12, (31.8% identity in 201 aa overlap). Also FT similar to other glyoxalases and metallo-beta-lactamase FT family proteins e.g. NP_386770.1|NC_003047 PUTATIVE FT HYDROXYACYLGLUTATHIONE HYDROLASE from Sinorhizobium FT meliloti (256 aa); etc. Also similar to other putative FT glyoxylases from Mycobacterium tuberculosis e.g. Rv1637c. FT BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO FT ZINC IONS." FT /db_xref="GOA:P96924" FT /db_xref="HSSP:1QH5" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:P96924" FT /protein_id="CAB07123.1" FT /translation="MSKDRLYFRQLLSGRDFAVGDMFATQMRNFAYLIGDRTTGDCVVV FT DPAYAAGDLLDALESDDMQLSGVLVTHHHPDHVGGSMMGFQLPGLAELLERASVPVHVN FT THEALWVSRVTGIPVGDLITHEHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGRLVAGD FT TLFLEGCGRTDFPGGDSDEMYRSLRQLAELPGDPTVFPGHWYSAEPSASLSEVKRSNYV FT YRPASLDQWRMLMGG" FT CDS 46840..47091 FT /transl_table=11 FT /locus_tag="Rv0634A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0634A, len: 83 aa. Hypothetical unknown protein." FT /db_xref="InterPro:IPR019239" FT /db_xref="UniProtKB/TrEMBL:Q8VKH3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55306.1" FT /translation="MGSDCGCGGYLWSMLKRVEIEVDDDLIQKVIRRYRVKGAREAVNL FT ALRTLLGEADTAEHGHDDEYDEFSDPNAWVPRRSRDTG" FT tRNA 47221..47293 FT /gene="tRNA-Thr(GGT)" FT /product="transfer RNA-Thr(GGT)" FT /anticodon=(pos:47254..47256,aa:Thr) FT tRNA 47330..47403 FT /gene="tRNA-Met(CAT)" FT /product="transfer RNA-Met(CAT)" FT /anticodon=(pos:47364..47366,aa:Met) FT CDS 47439..47606 FT /transl_table=11 FT /gene="rpmG2" FT /locus_tag="Rv0634B" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L33 RPMG2" FT /function="INVOLVED IN TRANSLATION MECHANISM." FT /note="Rv0634B, len: 55 aa. Probable rpmG2, 50S ribosomal FT protein L33. Note that Mycobacterium tuberculosis has a FT second rpmG gene: FT P96925|R33H_MYCTU|Rv2057c|MTCY63A.03|rpmG1 PUTATIVE 50S FT RIBOSOMAL PROTEIN L33 (55 aa), FASTA scores: opt: 391, E(): FT 2.9e-25, (100.0% identity in 55 aa overlap). BELONGS TO THE FT L33P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5W2" FT /db_xref="InterPro:IPR001705" FT /db_xref="InterPro:IPR018264" FT /db_xref="UniProtKB/Swiss-Prot:P0A5W2" FT /protein_id="CAE55307.1" FT /translation="MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLELKKFCPNC FT GKHQAHRETR" FT CDS 47657..48133 FT /transl_table=11 FT /locus_tag="Rv0635" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0635, (MTCY20H10.16), len: 158 aa. Conserved FT hypothetical protein, equivalent to NP_302287.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (159 aa); and highly similar to YV31_MYCLE|P54879 conserved FT hypothetical protein from Mycobacterium leprae (166 aa), FT FASTA scores: opt: 387, E(): 5.9e-21, (43.4% identity in FT 145 aa overlap). Also similar CAB77410.1|AL160431|SCD82.07 FT hypothetical protein from Streptomyces coelicolor (150 aa). FT And highly similar to two hypothetical proteins from FT Mycobacterium tuberculosis: Rv0504c|YV31_MYCTU|Q11168 (166 FT aa), FASTA scores: opt: 405, E(): 3.2e-22, (45.0% identity FT in 140 aa overlap); and Rv0637|MTY20H10_19 (2 ORFs FT downstream) (166 aa), FASTA score: (48.7% identity in 150 FT aa overlap)." FT /db_xref="InterPro:IPR016709" FT /db_xref="UniProtKB/Swiss-Prot:P96926" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07124.1" FT /translation="MALSADIVGMHYRYPDHYEVEREKIREYAVAVQNDDAWYFEEDGA FT AELGYKGLLAPLTFICVFGYKAQAAFFKHANIATAEAQIVQVDQVLKFEKPIVAGDKLY FT CDVYVDSVREAHGTQIIVTKNIVTNEEGDLVQETYTTLAGRAGEDGEGFSDGAA" FT CDS 48120..48548 FT /transl_table=11 FT /locus_tag="Rv0636" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0636, (MTCY20H10.17), len: 142 aa. Conserved FT hypothetical protein, equivalent to NP_302286.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (142 aa). Also highly similar to FT CAB77411.1|AL160431|SCD82.08 hypothetical protein from FT Streptomyces coelicolor (142 aa); and similar to others FT e.g. U28943|CELE04F6_3 from Caenorhabditis elegans (cosmid FT E04) (298 aa), FASTA scores: opt: 167, E(): 0.00064, (31.6 FT identity in 117 aa overlap)." FT /db_xref="GOA:P96927" FT /db_xref="InterPro:IPR002539" FT /db_xref="UniProtKB/TrEMBL:P96927" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07125.1" FT /translation="MALREFSSVKVGDQLPEKTYPLTRQDLVNYAGVSGDLNPIHWDDE FT IAKVVGLDTAIAHGMLTMGIGGGYVTSWVGDPGAVTEYNVRFTAVVPVPNDGKGAELVF FT NGRVKSVDPESKSVTIALTATTGGKKIFGRAIASAKLA" FT CDS 48552..49052 FT /transl_table=11 FT /locus_tag="Rv0637" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0637, (MTCY20H10.18), len: 166 aa. Conserved FT hypothetical protein, equivalent to FT NP_302285.1|NC_002677|YV31_MYCLE|P54879 conserved FT hypothetical protein from Mycobacterium leprae (166 aa), FT FASTA scores: opt: 352, E(): 4e-19, (39.2% identity in 148 FT aa overlap); and highly similar to others from FT Mycobacterium leprae e.g. NP_302287.1|NC_002677 conserved FT hypothetical protein (159 aa). Also highly similar to FT CAB77410.1|AL160431|SCD82.07 hypothetical protein from FT Streptomyces coelicolor (150 aa); FT Rv0635|NP_215149.1|NC_000962|MTY20H10_17 conserved FT hypothetical protein (two ORFs upstream) from Mycobacterium FT tuberculosis (158 aa), FASTA score: (49.3% identity in 150 FT aa overlap); and FT Rv0504c|NP_215018.1|NC_000962|YV31_MYCTU|Q11168 FT hypothetical protein from Mycobacterium tuberculosis (166 FT aa), FASTA scores: opt: 380, E(): 3.8e-21, (43.1% identity FT in 137 aa overlap)." FT /db_xref="InterPro:IPR016709" FT /db_xref="UniProtKB/Swiss-Prot:P96928" FT /protein_id="CAB07096.1" FT /translation="MALKTDIRGMIWRYPDYFIVGREQCREFARAVKCDHPAFFSEEAA FT ADLGYDALVAPLTFVTILAKYVQLDFFRHVDVGMETMQIVQVDQRFVFHKPVLAGDKLW FT ARMDIHSVDERFGADIVVTRNLCTNDDGELVMEAYTTLMGQQGDGSARLKWDKESGQVI FT RTA" FT tRNA 49251..49323 FT /gene="tRNA-Trp(CCA)" FT /product="transfer RNA-Trp(CCA)" FT /anticodon=(pos:49284..49286,aa:Trp) FT CDS 49464..49949 FT /transl_table=11 FT /gene="secE1" FT /locus_tag="Rv0638" FT /standard_name="secE" FT /product="PROBABLE PREPROTEIN TRANSLOCASE SECE1" FT /function="ESSENTIAL FOR PROTEIN EXPORT." FT /note="Rv0638, (MTCY20H10.19), len: 161 aa. Probable secE1, FT preprotein translocase (tail-anchored membrane protein) FT (see citation below), highly similar at C-terminal half to FT others e.g. P36690|SECE_STRGR PREPROTEIN TRANSLOCASE SECE FT SUBUNIT from Streptomyces griseus (86 aa), FASTA scores: FT opt: 220, E(): 4.6e-06, (35.4% identity in 96 aa overlap); FT P16920|SECE_ECOLI preprotein translocase sece subunit from FT Escherichia coli strains K12 and O157:H7 (127 aa), FASTA FT scores: opt: 122, E(): 0.34, (37.0% identity in 54 aa FT overlap); etc. Contains PS01067 Protein secE/sec61-gamma FT signature. BELONGS TO THE SECE/SEC61-GAMMA FAMILY. PART OF FT THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH FT COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE, SECF|Rv2586c, FT SECG|Rv1440 AND SECY|Rv0732. Note that previously known as FT secE." FT /db_xref="GOA:P0A5Z0" FT /db_xref="InterPro:IPR001901" FT /db_xref="InterPro:IPR005807" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Z0" FT /protein_id="CAE55308.1" FT /translation="MSDEGDVADEAVADGAENADSRGSGGRTALVTKPVVRPQRPTGKR FT SRSRAAGADADVDVEEPSTAASEATGVAKDDSTTKAVSKAARAKKASKPKARSVNPIAF FT VYNYLKQVVAEMRKVIWPNRKQMLTYTSVVLAFLAFMVALVAGADLGLTKLVMLVFG" FT misc_feature 49785..49871 FT /note="PS01067 Protein secE/sec61-gamma signature" FT CDS 49981..50697 FT /transl_table=11 FT /gene="nusG" FT /locus_tag="Rv0639" FT /product="PROBABLE TRANSCRIPTION ANTITERMINATION PROTEIN FT NUSG" FT /function="INFLUENCES TRANSCRIPTION TERMINATION AND FT ANTITERMINATION. ACTS AS A COMPONENT OF THE TRANSCRIPTION FT COMPLEX, AND INTERACTS WITH THE TERMINATION FACTOR RHO AND FT RNA POLYMERASE." FT /note="Rv0639, (MTCY20H10.20), len: 238 aa. Probable nusG, FT transcription antitermination protein, equivalent to FT NP_302283.1|NC_002677 transcription antitermination protein FT nusG from Mycobacterium leprae (228 aa). Also highly FT similar to others e.g. P36260|NUSG_STRGR from Streptomyces FT griseus (294 aa), FASTA scores: opt: 845, E(): 0, (55.4% FT identity in 233 aa overlap); etc. Note that shorter at the FT N-terminus than other nusG. Contains PS01014 Transcription FT termination factor nusG signature. BELONGS TO THE NUSG FT FAMILY." FT /db_xref="GOA:P65589" FT /db_xref="InterPro:IPR001062" FT /db_xref="InterPro:IPR005824" FT /db_xref="InterPro:IPR006645" FT /db_xref="InterPro:IPR008991" FT /db_xref="InterPro:IPR014722" FT /db_xref="InterPro:IPR015869" FT /db_xref="UniProtKB/Swiss-Prot:P65589" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07098.1" FT /translation="MTTFDGDTSAGEAVDLTEANAFQDAAAPAEEVDPAAALKAELRSK FT PGDWYVVHSYAGYENKVKANLETRVQNLDVGDYIFQVEVPTEEVTEIKNGQRKQVNRKV FT LPGYILVRMDLTDDSWAAVRNTPGVTGFVGATSRPSALALDDVVKFLLPRGSTRKAAKG FT AASTAAAAEAGGLERPVVEVDYEVGESVTVMDGPFATLPATISEVNAEQQKLKVLVSIF FT GRETPVELTFGQVSKI" FT misc_feature 50641..50670 FT /note="PS01014 Transcription termination factor nusG FT signature" FT CDS 50749..51177 FT /transl_table=11 FT /gene="rplK" FT /locus_tag="Rv0640" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L11 RPLK" FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA." FT /note="Rv0640, (MTCY20H11.21), len: 142 aa. Probable rplK, FT 50S ribosomal protein L11, equivalent to FT NP_302282.1|NC_002677 50S ribosomal protein L11 from FT Mycobacterium leprae (142 aa). Also highly similar to FT others e.g. P48954|RL11_STRCO|SCD82.19 50s ribosomal FT protein L11 from Streptomyces coelicolor (144 aa), FASTA FT scores: opt: 763, E(): 0, (84.6% identity in 143 aa FT overlap); etc. Contains PS00359 Ribosomal protein L11 FT signature. BELONGS TO THE L11P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P66056" FT /db_xref="InterPro:IPR000911" FT /db_xref="InterPro:IPR006519" FT /db_xref="InterPro:IPR020783" FT /db_xref="InterPro:IPR020784" FT /db_xref="InterPro:IPR020785" FT /db_xref="UniProtKB/Swiss-Prot:P66056" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07099.1" FT /translation="MAPKKKVAGLIKLQIVAGQANPAPPVGPALGQHGVNIMEFCKAYN FT AATENQRGNVIPVEITVYEDRSFTFTLKTPPAAKLLLKAAGVAKGSAEPHKTKVAKVTW FT DQVREIAETKKTDLNANDVDAAAKIIAGTARSMGITVE" FT misc_feature 51130..51174 FT /note="PS00359 Ribosomal protein L11 signature" FT CDS 51244..51951 FT /transl_table=11 FT /gene="rplA" FT /locus_tag="Rv0641" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L1 RPLA" FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL RNA FT AND IS LOCATED IN THE NEIGHBORHOOD OF THE SITE WHERE FT ELONGATION FACTOR TU IS BOUND TO THE RIBOSOME." FT /note="Rv0641, (MTCY20H10.22), len: 235 aa. Probable rplA, FT 50S ribosomal protein L1, equivalent to FT NP_302281.1|NC_002677 50S ribosomal protein L1 from FT Mycobacterium leprae (235 aa). Also highly similar to FT others e.g. P3625|RL1_STRGR 50s ribosomal protein L1 from FT Streptomyces griseus (240 aa), FASTA scores: opt: 1081, FT E(): 0, (72.2% identity in 230 aa overlap); etc. BELONGS TO FT THE L1P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P96932" FT /db_xref="InterPro:IPR002143" FT /db_xref="InterPro:IPR005878" FT /db_xref="InterPro:IPR016094" FT /db_xref="UniProtKB/Swiss-Prot:P96932" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07100.1" FT /translation="MSKTSKAYRAAAAKVDRTNLYTPLQAAKLAKETSSTKQDATVEVA FT IRLGVDPRKADQMVRGTVNLPHGTGKTARVAVFAVGEKADAAVAAGADVVGSDDLIERI FT QGGWLEFDAAIATPDQMAKVGRIARVLGPRGLMPNPKTGTVTADVAKAVADIKGGKINF FT RVDKQANLHFVIGKASFDEKLLAENYGAAIDEVLRLKPSSSKGRYLKKITVSTTTGPGI FT PVDPSITRNFAGE" FT CDS complement(52025..52930) FT /transl_table=11 FT /gene="mmaA4" FT /locus_tag="Rv0642c" FT /product="METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL FT MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID FT SYNTHASE)" FT /function="INVOLVED IN MYCOLIC ACIDS MODIFICATION. FT CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT FT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A FT SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL FT GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO FT PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a FT major constituent of the mycobacterial cell wall complex. FT Methyl transfer results in formation of a secondary hydroxy FT group with an adjacent methyl branch; Olefinic mycolic acid FT methyl transferase." FT /EC_number="2.1.1.-" FT /note="Rv0642c, (MTCY20H10.23c), len: 301 aa. mmaA4, FT methoxy mycolic acid synthase 4 (methyltransferase) (EC FT 2.1.1.-) (see citations below). Equivalent to FT AAC44876|AAC44876.1|cmaA methyl transferase (mycolic acid FT modification protein) from Mycobacterium bovis BCG strain FT Pasteur (298 aa); NP_302280.1|NC_002677 methyl mycolic acid FT synthase 4 from Mycobacterium leprae (298 aa); and highly FT similar to others from Mycobacteria e.g. downstream ORF FT P72027|mmaA3|Rv0643c|MTCY20H10.24c PUTATIVE METHOXY MYCOLIC FT ACID SYNTHASE 3 from Mycobacterium tuberculosis (293 aa)." FT /db_xref="GOA:Q79FX8" FT /db_xref="InterPro:IPR003333" FT /db_xref="PDB:2FK7" FT /db_xref="PDB:2FK8" FT /db_xref="PDB:3HA3" FT /db_xref="PDB:3HA5" FT /db_xref="PDB:3HA7" FT /db_xref="UniProtKB/TrEMBL:Q79FX8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07101.1" FT /translation="MTRMAEKPISPTKTRTRFEDIQAHYDVSDDFFALFQDPTRTYSCA FT YFEPPELTLEEAQYAKVDLNLDKLDLKPGMTLLDIGCGWGTTMRRAVERFDVNVIGLTL FT SKNQHARCEQVLASIDTNRSRQVLLQGWEDFAEPVDRIVSIEAFEHFGHENYDDFFKRC FT FNIMPADGRMTVQSSVSYHPYEMAARGKKLSFETARFIKFIVTEIFPGGRLPSTEMMVE FT HGEKAGFTVPEPLSLRPHYIKTLRIWGDTLQSNKDKAIEVTSEEVYNRYMKYLRGCEHY FT FTDEMLDCSLVTYLKPGAAA" FT CDS complement(52995..53876) FT /transl_table=11 FT /gene="mmaA3" FT /locus_tag="Rv0643c" FT /product="METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL FT MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID FT SYNTHASE)" FT /function="INVOLVED IN MYCOLIC ACIDS MODIFICATION. FT CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT FT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A FT SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL FT GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO FT PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a FT major constituent of the mycobacterial cell wall complex. FT Methyl transfer results in formation of a secondary hydroxy FT group with an adjacent methyl branch; Olefinic mycolic acid FT methyl transferase." FT /EC_number="2.1.1.-" FT /note="Rv0643c, (MTCY20H10.24c), len: 293 aa. mmaA3, FT methoxy mycolic acid synthase 3 (methyltransferase) (EC FT 2.1.1.-) (see citations below). Equivalent to FT AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid FT modification protein) from Mycobacterium bovis BCG strain FT Pasteur (289 aa); and highly similar to others from FT Mycobacteria e.g. upstream ORF FT P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC FT ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa)." FT /db_xref="GOA:P72027" FT /db_xref="HSSP:1KP9" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/TrEMBL:P72027" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07102.1" FT /translation="MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFE FT RDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKN FT QHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNA FT MPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVT FT KAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRM FT GYIDCNQFTLAK" FT CDS complement(54024..54887) FT /transl_table=11 FT /gene="mmaA2" FT /locus_tag="Rv0644c" FT /product="METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 (METHYL FT MYCOLIC ACID SYNTHASE 2) (MMA2) (HYDROXY MYCOLIC ACID FT SYNTHASE)" FT /function="INVOLVED IN MYCOLIC ACIDS MODIFICATION. FT CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT FT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A FT SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL FT GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO FT PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a FT major constituent of the mycobacterial cell wall complex. FT Methyl transfer results in formation of a secondary hydroxy FT group with an adjacent methyl branch; Olefinic mycolic acid FT methyl transferase. HAS ALSO CYCLOPROPANE FUNCTION." FT /EC_number="2.1.1.-" FT /note="Rv0644c, (MTCY20H10.25c), len: 287 aa. mmaA2, FT methoxy mycolic acid synthase 2 (methyltransferase) (EC FT 2.1.1.-) (see citations below). Equivalent to FT AAC44874|AAC44874.1|cmaC methyl transferase (mycolic acid FT modification protein) from Mycobacterium bovis BCG strain FT Pasteur (287 aa); and highly similar to others from FT Mycobacteria e.g. upstream ORF FT P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC FT ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). FT Note that alternative start is at position 739247." FT /db_xref="GOA:Q79FX6" FT /db_xref="InterPro:IPR003333" FT /db_xref="PDB:1TPY" FT /db_xref="UniProtKB/TrEMBL:Q79FX6" FT /protein_id="CAB07103.1" FT /translation="MVNDLTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTL FT EEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGLTLSKNQAAHVQ FT KSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGV FT LLLHTITGLTRQQMVDHGLPLTLWLARFLKFIATEIFPGGQPPTIEMVEEQSAKTGFTL FT TRRQSLQPHYARTLDLWAEALQEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVN FT QFTLAK" FT CDS complement(55054..55914) FT /transl_table=11 FT /gene="mmaA1" FT /locus_tag="Rv0645c" FT /product="METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL FT MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID FT SYNTHASE)" FT /function="INVOLVED IN MYCOLIC ACIDS MODIFICATION. FT CATALYZES UNUSUAL S-ADENOSYL-METHIONINE-DEPENDENT FT TRANSFORMATION OF A CIS-OLEFIN MYCOLIC ACID INTO A FT SECONDARY ALCOHOL. CATALYZES INTRODUCTION OF A HYDROXYL FT GROUP AT THE DISTAL POSITION ON MYCOLIC ACID CHAINS TO FT PRODUCE THE HYDROXYL MYCOLATE. Mycolic acids represent a FT major constituent of the mycobacterial cell wall complex. FT Methyl transfer results in formation of a secondary hydroxy FT group with an adjacent methyl branch; Olefinic mycolic acid FT methyl transferase." FT /EC_number="2.1.1.-" FT /note="Rv0645c, (MTCY20H10.26c), len: 286 aa. mmaA1, FT methoxy mycolic acid synthase 1 (methyltransferase) (EC FT 2.1.1.-) (see citations below). Equivalent to FT NP_302279.1|NC_002677 methyl mycolic acid synthase 1 from FT Mycobacterium leprae (286 aa); and highly similar to others FT from Mycobacteria e.g. upstream ORF FT P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC FT ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa)." FT /db_xref="GOA:P0C5C3" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/Swiss-Prot:P0C5C3" FT /protein_id="CAB07126.1" FT /translation="MAKLRPYYEESQSAYDISDDFFALFLDPTWVYTCAYFERDDMTLE FT EAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRAVEKYDVNVIGLTLSRNHYERSKD FT RLAAIGTQRRAEARLQGWEEFEENVDRIVSFEAFDAFKKERYLTFFERSYDILPDDGRM FT LLHSLFTYDRRWLHEQGIALTMSDLRFLKFLRESIFPGGELPSEPDIVDNAQAAGFTIE FT HVQLLQQHYARTLDAWAANLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINVAQ FT FTMTK" FT CDS complement(55961..56866) FT /transl_table=11 FT /gene="lipG" FT /locus_tag="Rv0646c" FT /product="PROBABLE LIPASE/ESTERASE LIPG" FT /function="UNKNOWN; LIPOLYTIC ENZYME INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="3.1.-.-" FT /note="Rv0646c, (MTCY20H10.27c), len: 301 aa. Probable FT lipG, lipase/esterase (EC 3.1.-.-), equivalent to FT NP_302278.1|NC_002677 probable hydrolase from Mycobacterium FT leprae (304 aa). Also highly similar to various hydrolases, FT especially lipases e.g. AA61351.1|X88895 carboxyl esterase FT from Acinetobacter calcoaceticus (312 aa), FASTA scores: FT opt: 867, E(): 0, (50.2% identity in 279 aa overlap); etc. FT Also similar to transferases e.g. P77026 MACROLIDE FT 2'-PHOSPHOTRANSFERASE II from Escherichia coli (279 aa), FT FASTA scores: E(): 1.3e-14, (32.5% identity in 286 aa FT overlap). Similar to M. tuberculosis non-heme FT bromoperoxidases and epoxide hydrolases." FT /db_xref="GOA:P96935" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:P96935" FT /protein_id="CAB07104.1" FT /translation="MDIRSGTAVSGDVKLYYEDMGDLDHPPVLLIMGLGAQMLLWRTDF FT CARLVAKGLRVIRYDNRDVGLSTKTERHRPGQPLATRLVRSWLGLPSQAAYTLEDMAAD FT AAALLDHLDVKHAHVVGASMGGMIAQIFAARFAQRTKTLAVIFSSNNHRFLPPPAPRAL FT LALLTGPPPDSPRDVIVDNAVRVSKIIGSPAYPIPEDQVRAEAAESYDRNFHPWGIAQQ FT FSAILGSGSLLRYDRRIVAPTVVIHGRADKLMRPFGGRAVARAINGARLVLIDGMGHDL FT PRQLWDRVIGELTRNFSEAG" FT CDS complement(56878..58344) FT /transl_table=11 FT /locus_tag="Rv0647c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0647c, (MTCY20H10.28c), len: 488 aa. Conserved FT hypothetical protein, equivalent to NP_302277.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (448 aa). Also showing similarity to a variety of FT hypothetical ABC1-LIKE proteins or conserved hypothetical FT proteins e.g. D90908_28|P73627 ABC1-LIKE PROTEIN from FT Synechocystis (585 aa), FASTA scores: E(): 1.8e-31, (29.1% FT identity in 474 aa overlap); Q55884 HYPOTHETICAL6 5.0 KD FT PROTEIN (567 aa), FASTA scores: opt: 583, E(): 5.7e-30, FT (28.1% identity in 416 aa overlap); etc. Also similar to FT Rv3197 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis." FT /db_xref="GOA:P96936" FT /db_xref="InterPro:IPR000719" FT /db_xref="InterPro:IPR004147" FT /db_xref="InterPro:IPR011009" FT /db_xref="UniProtKB/Swiss-Prot:P96936" FT /protein_id="CAB07127.1" FT /translation="MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGSTT FT HREVAKLDRVPLPVEAARVAATGWQVTRTAVRFIGRLPRKGPWQQKVIKELPQTFADLG FT PTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLFASF FT EEEPFASASIAQVHYATLRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAKLGRR FT LSAQDVVADFADNLAEELDFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLT FT MERVHGIRIDNAAAIRKAGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLYVDEAGR FT IVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDL FT ERFATPLTMQSLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPR FT WQMMSDPQLTGYFANFMVEVSREHQSDIEV" FT CDS 58446..62093 FT /transl_table=11 FT /locus_tag="Rv0648" FT /product="ALPHA-MANNOSIDASE" FT /function="Alpha-mannosidase activity: hydrolysis of FT terminal, non-reducing alpha-D-mannose residues in FT alpha-D-mannosides." FT /EC_number="3.2.1.-" FT /note="Rv0648, (MTCY20H10.29), len: 1215 aa. FT Alpha-mannosidase (EC 3.2.1.-) (see citation below), FT showing some similarity to hypothetical proteins and FT various sugar hydrolases e.g. SYCSLRA_6|Q55528 HYPOTHETICAL FT 1 20.4 kDa PROTEIN from Synechocystis (1042 aa), FASTA FT scores: opt: 260, E(): 3.6e-08, (23.4% identity in 602 aa FT overlap); etc. Contains PS00659 Glycosyl hydrolases family FT 5 signature." FT /db_xref="GOA:P96937" FT /db_xref="InterPro:IPR000602" FT /db_xref="InterPro:IPR011013" FT /db_xref="InterPro:IPR011330" FT /db_xref="InterPro:IPR011682" FT /db_xref="InterPro:IPR015341" FT /db_xref="InterPro:IPR018905" FT /db_xref="UniProtKB/TrEMBL:P96937" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07105.1" FT /translation="MMGGTYNEPNTNLTSPETTIRNLVHGIGFQRDVLGAEPATAWQLD FT VFGHDPQFPGLAADAGLTSSSWARGPHHQWGPAQGGVDRMQFCSEFEWIAPSGRGLLTH FT YMPAHYSAGWSMDSSTSLADAEAATYALFDQLKKVALTRNVLLPVGTDYTPPNKWVTAI FT HRDWGARYTWPRFVCALPKEFFAAVRAELAKRGWVPSPQTRDMNPIYTGKDVSYIDTKQ FT ANRAAENAVLEAERFAVFAALLTGAEYPQAALAKAWVQLAYGAHHDAITGSESDQVYLD FT LLTGWRDAWELGRAARDNSLRLLSGAVAASHDRVVVWNPLTQRRTDIVTARVDPPLQAG FT VRVFDPDGAEVAALVEHDGRSVTWLACDVPSLGWRVYRLVPADEAPGWELVPGTDIANE FT HYRLAVDPERGGALSSLVQDGRQLIAAGRVANELALYEEYPSHPTQGEGPWHLLPTGPV FT VCSSACPAQVQAYRGPLGQRLVVRGRIGTLLRYTQTLTLWDGVDRVDCRTSIDEFTGED FT RLLRLRWPCPVPGAMPISEVGDAVVGRGFALLHEGPESVDTAQHPWTLDNPAYGWFGLS FT SAVRVRAGDGVRAVSVAEVVSPTETVSGPMARDLMVALVRAGVTATCSGADKPRYGHLD FT VDSNLPDARIALGGPDRNTFTKAVLAEAAPAYTAELQRQLAKTGTARVWVPAANPLARA FT WLPGADLRAPCALPVLVIDGRDEKHLRAAVASLADDLADAEIVVHQRAAPQMEPFEDRT FT VALLNRGVPSFAVDSEGTLHTALMRSCTGWPSGVWIDQPRRTAPDGSNFQLQHWTHHFD FT YALVCGGGDWRRAGIPARSAQFSHPLLAVAPRRPQGELPAVGSLLHVEPADSVQLGALK FT AAGNPLAAGSARPVQPAAVALRLVQTTGADTPVTIGCELGKVGALRPADLLETPLAMAR FT ARKSSIDLHGYQVATVLARLDVAADMANVLAADDVALAPHAETAQPQYARYWLHNRGPA FT PLGGLPAVAHLHPRRVRGQPGDDVVLRLTAASDCTDSVLGGVVDVVCPLGWPATPARLP FT FTLGAGAHLQADIALSIPAGAPPGPYPVRAQLRVVDTAVPAAWRQVVEDVCVVTVGADS FT DLEELVYLVDGPADIELAAGDRARLAVTIGSRAHAELALDAHSISPWGTWEWIGPPALG FT AVLPARGMAKLAFDVTPPAWLEPGQWWALVRVGCAGQLVYSPAVKVSVT" FT misc_feature 58446..58475 FT /note="PS00659 Glycosyl hydrolases family 5 signature" FT CDS 62090..62764 FT /transl_table=11 FT /gene="fabD2" FT /locus_tag="Rv0649" FT /product="POSSIBLE MALONYL COA-ACYL CARRIER PROTEIN FT TRANSACYLASE FABD2 (MCT)" FT /function="INVOLVED IN LIPID METABOLISM; FATTY ACID FT BIOSYNTHESIS [CATALYTIC ACTIVITY: MALONYL-CoA + FT [ACYL-CARRIER PROTEIN] = CoA + MALONYL-[ACYL-CARRIER FT PROTEIN]]." FT /EC_number="2.3.1.39" FT /note="Rv0649, (MTCY20H10.30), len: 224 aa. Possible fabD2, FT malonyl CoA-acyl carrier protein transacylase (EC FT 2.3.1.39), similar to MTFABD|FABD_MYCTU|Q10501|Rv2243 FT malonyl CoA-acyl carrier protein transacylase from FT Mycobacterium tuberculosis (302 aa), FASTA scores: opt: FT 133, E(): 0.074, (31.3% identity in 147 aa overlap)." FT /db_xref="GOA:Q79FX5" FT /db_xref="UniProtKB/TrEMBL:Q79FX5" FT /protein_id="CAE55309.1" FT /translation="MSGRSRLPGSSSRRDAARIVAERVVATVAGVAVAVDEVDAAEARL FT RDGPRAAALPASGTSEGRQLRRWLTQLIVTERVVAAEAAARGLTAAGAPAEADLLPDAT FT ARLEIGSVAAAVLADPLARALFAAVTARVAVTDDAVADYHARNPLRFAAPCPGQHGWRA FT PAAAAPPLDQVRRAITEHLLGAARRRAFRVWLDARRNALVVLAPGYEHPGDPRQPDNTR FT RH" FT CDS 62764..63672 FT /transl_table=11 FT /locus_tag="Rv0650" FT /product="POSSIBLE SUGAR KINASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN SPECIFIC SUGAR FT METABOLISM OR REGULATION." FT /EC_number="2.7.-.-" FT /note="Rv0650, (MTCY20H10.31), len: 302 aa. Possible sugar FT kinase, highly similar to others e.g. CAB95296.1|AL359779 FT putative sugar kinase from Streptomyces coelicolor (317 FT aa); NP_406512.1|NC_003143 putative sugar kinase from FT Yersinia pestis (290 aa); NP_229269.1|NC_000853 glucokinase FT from Thermotoga maritima (317 aa); etc. Contains PS01125 FT ROK family signature. BELONGS TO THE ROK (NAGC/XYLR) FT FAMILY." FT /db_xref="GOA:P96939" FT /db_xref="InterPro:IPR000600" FT /db_xref="UniProtKB/TrEMBL:P96939" FT /protein_id="CAB07107.1" FT /translation="MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAV FT AEMIADALGVAGGAVGGVGIASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVPGVPV FT RLGGDGVCMALGEHWLGAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVGHVV FT VDPDGSPCPCGGRGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRA FT FRRGAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFLAGLRV FT VPAELGGAAGLVGAARLAAIA" FT misc_feature 63163..63246 FT /note="PS01125 ROK family signature" FT CDS 64003..64539 FT /transl_table=11 FT /gene="rplJ" FT /locus_tag="Rv0651" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L10 RPLJ" FT /function="INVOLVED IN TRANSLATION MECHANISMS." FT /note="Rv0651, (MTCY20H10.32), len: 178 aa. Probable rplJ, FT 50S ribosomal protein L10, equivalent to FT NP_302276.1|NC_002677 50S ribosomal protein L10 from FT Mycobacterium leprae (177 aa). Also highly similar to FT others e.g. P36257|RL10_STRGR 50s ribosomal protein L10 FT from Streptomyces griseus (185 aa), FASTA scores: opt: 633, FT E(): 0, (59.0 % identity in 173 aa overlap); etc. BELONGS FT TO THE L10P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66044" FT /db_xref="InterPro:IPR001790" FT /db_xref="InterPro:IPR002363" FT /db_xref="UniProtKB/Swiss-Prot:P66044" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07108.1" FT /translation="MARADKATAVADIAAQFKESTATLITEYRGLTVANLAELRRSLTG FT SATYAVAKNTLIKRAASEAGIEGLDELFVGPTAIAFVTGEPVDAAKAIKTFAKEHKALV FT IKGGYMDGHPLTVAEVERIADLESREVLLAKLAGAMKGNLAKAAGLFNAPASQLARLAA FT ALQEKKACPGPDSAE" FT CDS 64576..64968 FT /transl_table=11 FT /gene="rplL" FT /locus_tag="Rv0652" FT /standard_name="L7|L12" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L7/L12 RPLL (SA1)" FT /function="INVOLVED IN TRANSLATION MECHANISMS: SEEMS TO BE FT THE BINDING SITE FOR SEVERAL OF THE FACTORS INVOLVED IN FT PROTEIN SYNTHESIS AND APPEARS TO BE ESSENTIAL FOR ACCURATE FT TRANSLATION." FT /note="Rv0652, (MTCY20H10.33), len: 130 aa. Probable rplL FT (alternate gene name: L7|L12), 50S ribosomal protein FT L7/L12, equivalent to NP_302275.1|NC_002677 50S ribosomal FT protein L7/L12 from Mycobacterium leprae (130 aa); and FT P37381|RL7_MYCBO 50s ribosomal protein L7/L12 from FT Mycobacterium bovis (130 aa). Also highly similar to others FT e.g. P02396|RL7_STRGR 50S RIBOSOMAL PROTEIN L7/L12 from FT Streptomyces griseus (127 aa); etc. BELONGS TO THE L12P FT FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5V2" FT /db_xref="InterPro:IPR000206" FT /db_xref="InterPro:IPR008932" FT /db_xref="InterPro:IPR013823" FT /db_xref="InterPro:IPR014719" FT /db_xref="UniProtKB/Swiss-Prot:P0A5V2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07109.1" FT /translation="MAKLSTDELLDAFKEMTLLELSDFVKKFEETFEVTAAAPVAVAAA FT GAAPAGAAVEAAEEQSEFDVILEAAGDKKIGVIKVVREIVSGLGLKEAKDLVDGAPKPL FT LEKVAKEAADEAKAKLEAAGATVTVK" FT CDS complement(64961..65656) FT /transl_table=11 FT /locus_tag="Rv0653c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0653c, (MTCI376.23, MTCY20H10.34c), len: 231 aa. FT Possible transcriptional regulator, TetR family, similar in FT N-terminus to others e.g. CAC03642.1|AL391338 putative FT TetR-family transcriptional regulator from Streptomyces FT coelicolor (190 aa); Q51597 CAM REPRESSOR from Pseudomonas FT putida (186 aa), FASTA scores: opt: 150, E(): 0.00085, FT (27.8% identity in 97 aa overlap); etc. Also some FT similarity to Mycobacterium tuberculosis hypothetical FT transcriptional regulators Rv0681 and Rv1816. Contains FT probable helix-turn helix motif from aa 27-48 (Score 1156, FT +3.12 SD)." FT /db_xref="GOA:P96941" FT /db_xref="InterPro:IPR001647" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:P96941" FT /protein_id="CAB07128.1" FT /translation="MTSQTGVRDELLHAGVRLLDDHGPDALQTRKVAAAAGTSTMAVYT FT HFGGMRGLIAAIAEEGLRQFDVALTVPQTADPVADLLAIGTAYRRYAIERPHMYRLMFG FT STSAHGINVPARDVLTLKVAEIEHQHPSFAHVVRAVHRCLLAGRFATALGADDDTAIVA FT TAAQFWSQIHGFVMLELAGFYGDRGAAVEPVLAAMTVNLLVALGDSPERAQCSLRAEQT FT QKNTLGRAT" FT CDS 65727..67232 FT /transl_table=11 FT /locus_tag="Rv0654" FT /product="PROBABLE DIOXYGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0654, (MTCI376.22), len: 501 aa. Probable FT dioxygenase (EC 1.-.-.-), highly similar to others eg FT AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase FT (involved in tetraene formation) from Streptomyces FT antibioticus (456 aa); CAB56138.1| AL117669 putative FT dioxygenase from Streptomyces coelicolor (503 aa); T51734 FT neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid FT dioxygenase) from Arabidopsis thaliana (538 aa); Q53353 FT LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE from Pseudomonas FT paucimobilis (Sphingomonas paucimobilis), FASTA scores: FT opt: 280, E(): 2.3e-11, (28.5% identity in 523 aa overlap); FT etc. Also some similarity with Rv0913c|MTCY21C12.07c FT POSSIBLE DIOXYGENASE from Mycobacterium tuberculosis (501 FT aa), FASTA score: (29.5% identity in 522 aa overlap)." FT /db_xref="GOA:O06785" FT /db_xref="InterPro:IPR004294" FT /db_xref="UniProtKB/TrEMBL:O06785" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09380.1" FT /translation="MTTAQAAESQNPYLEGFLAPVSTEVTATDLPVTGRIPEHLDGRYL FT RNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWYRNRWVRTPAVCAALGEPISARP FT HPRTGIIEGGPNTNVLTHAGRTLALVEAGVVNYELTDELDTVGPCDFDGTLHGGYTAHP FT QRDPHTGELHAVSYSFARGHRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVI FT YDLPVTFDPMQVVPASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYA FT WNPSYPARVGVMPREGGNEDVRWFDIEPCYVYHPLNAYSECRNGAEVLVLDVVRYSRMF FT DRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQEFPRINETLVGGPHRFAYTVGI FT EGGFLVGAGAALSTPLYKQDCVTGSSTVASLDPDLLIGEMVFVPNPSARAEDDGILMGY FT GWHRGRDEGQLLLLDAQTLESIATVHLPQRVPMGFHGNWAPTT" FT CDS 67244..68323 FT /transl_table=11 FT /gene="mkl" FT /locus_tag="Rv0655" FT /product="POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING FT PROTEIN ABC TRANSPORTER MKL" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT RIBONUCLEOTIDE ACROSS THE MEMBRANE. RESPONSIBLE FOR ENERGY FT COUPLING TO THE TRANSPORT SYSTEM." FT /note="Rv0655, (MTCI376.21), len: 359 aa. Possible mkl, FT ribonucleotide-transport ATP-binding protein ABC FT transporter (see Braibant et al., 2000), equivalent to FT P30769|MKL_MYCLE|ML1892 POSSIBLE RIBONUCLEOTIDE TRANSPORT FT ATP-BINDING PROTEIN from Mycobacterium leprae (347 aa), FT FASTA scores: opt: 2021, E(): 0, (92.2% identity in 335 aa FT overlap). Also highly similar to many e.g. FT AB92896.1|AL356992 putative ABC-transporter ATP-binding FT protein from Streptomyces coelicolor (343 aa); FT NP_253146.1|NC_002516 probable ATP-binding component of ABC FT transporter from Pseudomonas aeruginosa (269 aa); FT P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding FT protein from Escherichia coli (269 aa), FASTA scores: opt: FT 644, E(): 3.4e-33, (38.5% identity in 244 aa overlap); etc. FT Also similar to many other Mycobacterium tuberculosis ABC FT transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351 aa), FT FASTA score: (33.6% identity in 241 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC FT transporters family signature. BELONGS TO THE ATP-BINDING FT TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:P63357" FT /db_xref="InterPro:IPR003439" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/Swiss-Prot:P63357" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09379.1" FT /translation="MRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWED FT VTLTIPAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDIIECSAKELYEIRT FT LFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLALVGLGGDEKKFPGE FT ISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTAYLSQLIMDINAQIDATILIVTH FT NINIARTVPDNMGMLFRKHLVMFGPREVLLTSDEPVVRQFLNGRRIGPIGMSEEKDEAT FT MAEEQALLDAGHHAGGVEEIEGVPPQISATPGMPERKAVARRQARVREMLHTLPKKAQA FT AILDDLEGTHKYAVHEIGQ" FT misc_feature 67421..67444 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 67733..67777 FT /note="PS00211 ABC transporters family signature" FT CDS complement(68711..69094) FT /transl_table=11 FT /locus_tag="Rv0656c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0656c, (MTCI376.20), len: 127 aa. Conserved FT hypothetical protein, showing similarity with proteins from FT Mycobacterium tuberculosis e.g. Rv2757c, Rv2546, etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:O06783" FT /protein_id="CAB09378.1" FT /translation="MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQM FT SRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVGALSVVDLLICDTAAARGLVVLHDD FT ADYELAERHLPDIRVRRVVSADD" FT CDS complement(69189..69344) FT /transl_table=11 FT /locus_tag="Rv0657c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0657c, (MTCI376.19), len: 51 aa. Conserved FT hypothetical protein, showing similarity with hypothetical FT proteins from Mycobacterium tuberculosis e.g. FT Rv2009|MT2064.1|MTCY39.08c|YW08_MYCTU|Q10848 (80 aa), FASTA FT scores: opt: 107, E(): 0.0038, (45.8% identity in 48 aa FT overlap), Rv2871, Rv1560, etc. Also some similarity with FT AL020958|SC4H8_7 from Streptomyces coelicolor (66 aa), FT FASTA score: (41.0% identity in 39 aa overlap)." FT /db_xref="InterPro:IPR019239" FT /db_xref="UniProtKB/TrEMBL:O06782" FT /protein_id="CAB09377.1" FT /translation="MSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEA FT LARSRE" FT CDS complement(69420..70136) FT /transl_table=11 FT /locus_tag="Rv0658c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN. SUPPOSED INVOLVED IN STATIONARY-PHASE FT SURVIVAL." FT /note="Rv0658c, (MTCI376.18), len: 238 aa. Probable FT conserved integral membrane protein, equivalent to a FT predicted homologous protein from Mycobacterium smegmatis FT (see citation below), and showing some similarity with FT P33774|YPRB_ECOLI hypothetical 24.3 kDa protein from FT Escherichia coli (217 aa), FASTA scores: opt: 174, E(): FT 5.3e-05, (25.6% identity in 223 aa overlap). Also similar FT to Rv1863c and Rv0804 from Mycobacterium tuberculosis." FT /db_xref="GOA:O06781" FT /db_xref="InterPro:IPR003675" FT /db_xref="UniProtKB/TrEMBL:O06781" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09376.1" FT /translation="MEAGRADTVAPSHRWGLGAFLVVELVFLVASTSLAVVLTGHGPVS FT AGVLALALAAPTVVAAGLAILITRLRGNGLRTDLRLRWSWRGLRLGLMFGFGGMLVTIP FT ASLVYTAIVGPEANSAVVRIFGGVRASWPWALVVFLVVVFVAPLCEEIIYRGLLWGAVD FT RRWGRWAALVVTTVVFALAHLEFARAPLLVVVAIPIALARFYSGGLLASIVTHQVTNLL FT PGIVLLLGLTGAISLP" FT CDS complement(70412..70720) FT /transl_table=11 FT /locus_tag="Rv0659c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0659c, (MTCI376.17), len: 102 aa. Conserved FT hypothetical protein, weakly similar to other Mycobacterium FT tuberculosis hypothetical proteins e.g. Rv1942c, Rv1495, FT etc." FT /db_xref="GOA:O06780" FT /db_xref="InterPro:IPR003477" FT /db_xref="InterPro:IPR011067" FT /db_xref="UniProtKB/TrEMBL:O06780" FT /protein_id="CAB09387.1" FT /translation="MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGL FT VSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRRITRLSPARLHEACQTLRASTGC" FT CDS complement(70707..70952) FT /transl_table=11 FT /locus_tag="Rv0660c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0660c, (MTCI376.16), len: 81 aa. Conserved FT hypothetical protein, showing some similarity to FT AF016485_130 from Halobacterium sp (100 aa), FASTA scores: FT (32.4% identity in 74 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06779" FT /protein_id="CAB09386.1" FT /translation="MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQD FT VQAYTERPLTDDENALAEIADWGPAEDWADWADAAR" FT CDS complement(71062..71499) FT /transl_table=11 FT /locus_tag="Rv0661c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0661c, (MTCI376.15), len: 145 aa. Conserved FT hypothetical protein, similar to Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv2863|MTV003.09|MTV003_7 (126 FT aa), FASTA scores: E(): 0.00087, (30.4% identity in 125 aa FT overlap), Rv0749|MTV041.23 (163 aa); Rv0277c, Rv2530c, FT etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:O06778" FT /protein_id="CAB09385.1" FT /translation="MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQ FT EFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIEATSKRGLTLFETTPGLEACDAVLA FT AVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR" FT CDS complement(71496..71864) FT /transl_table=11 FT /locus_tag="Rv0662c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0662c, (MTCI376.14), len: 133 aa. Conserved FT hypothetical protein, showing weak similarity with other FT hypothetical proteins from Mycobacterium tuberculosis e.g. FT Rv2871, Rv1241, Rv2550c, etc." FT /db_xref="UniProtKB/TrEMBL:O06777" FT /protein_id="CAB09384.1" FT /translation="MFLPNTRAYRRYNRSVWAVRGSTRPQWQPPPKFQHAKCMSMRLAH FT RLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSV FT PEPRELKQELEALRARRG" FT CDS 71864..74227 FT /transl_table=11 FT /gene="atsD" FT /locus_tag="Rv0663" FT /product="POSSIBLE ARYLSULFATASE ATSD (ARYL-SULFATE FT SULPHOHYDROLASE) (ARYLSULPHATASE)" FT /function="THOUGHT TO PLAY AN IMPORTANT ROLE IN THE FT MINERALIZATION OF SULFATES [CATALYTIC ACTIVITY: A phenol FT sulfate + H2O = a phenol + sulfate]." FT /EC_number="3.1.6.1" FT /note="Rv0663, (MTCI376.13c), len: 787 aa. Possible atsD, FT arylsulfatase (EC 3.1.6.1), similar to others e.g. FT P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa FT (532 aa), FASTA scores: opt: 653, E(): 0, (33.1% identity FT in 544 aa overlap); etc. Also similar to FT P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from Mycobacterium FT tuberculosis (787 aa), FASTA score: (38.9% identity in 769 FT aa overlap); and other arylsulfatases from Mycobacterium FT tuberculosis e.g. Rv3299c|ATSB (970 aa), Rv0711, etc. FT Contains PS00523 Sulfatases signature 1. BELONGS TO THE FT SULFATASE FAMILY." FT /db_xref="GOA:O06776" FT /db_xref="HSSP:1E33" FT /db_xref="InterPro:IPR000917" FT /db_xref="InterPro:IPR017849" FT /db_xref="InterPro:IPR017850" FT /db_xref="UniProtKB/TrEMBL:O06776" FT /protein_id="CAB09383.1" FT /translation="MPQPRTHLPIPSAARTGLITYDAKDPDSTYPPIEQLRPPAGAPNV FT LLILLDDVGFGASSAFGGPCRTSTAELLAGNGLRYNRFHTTALCSPTRQALLTGRNHHS FT AGMGGITEIATGAPGYSSVLPNTMSPIARTLKLNGYNTAQFGKCHEVPVWQTSPVGPFD FT AWPSGGGGFEYFYGFIGGEANQWYPSLYEGTTPVEVNRTPEEGYHFMADMTDKALGWIG FT QQKALAPDRPFFVYFAPGATHAPHHVPREWADKYRGRFDVGWDALREETFARQKELGVI FT PADCQLTARHAEIPAWDDMPEDLKPVLCRQMEVYAGFLEYTDHHVGRLVDGLQRLGVLD FT DTLVFYIIDDNGASAEGTINGTYNEMLNFNGLADIETPRFMTDRLDKFGGPESYNHYSV FT GWAHAMDTPYQWTKQVASHWGGTRNGTIVHWPNGIAAKGEMRWQFHHVIDVAPTILEAA FT GLPEPLFVNGVQQHPIEGVSMAYSFDDAQAPDRHETQYFEMFGNRGIYHKGWTAVTKHK FT TPWILVGEQTVAFDDDVWELYDTTKDWSQAKDLAKEMPEKLHELQRLWLIEATRYNVLP FT LDDDTASRINPDLAGRPVLIRGNTQVLFSNMGRLSENCVLNLKNKSHTVTAEVEVPETG FT AEGVIVAQGASIGGWSLYANDGKLKYCYNLGGIKHFYAESADPLPAGAHQVRMEFAYAG FT GGLGKGGEVTLYVDGQQVGEGHVEATLAIVFSADDGCDVGMDSGSPVSPDYAPGSNAFN FT GRIKGVQLAIAEAAAAAGHLVDPEHAIRIALARQ" FT misc_feature 72122..72160 FT /note="PS00523 Sulfatases signature 1" FT CDS 74259..74531 FT /transl_table=11 FT /locus_tag="Rv0664" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0664, (MTCI376.12c), len: 90 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O06775" FT /protein_id="CAB09382.1" FT /translation="MEKSRCHAVAHGGGCAGSAKSHKSGGRCGQGRGAGDSHGTRGAGR FT RYRAASAPHPLAVGAHLRDELAKRSADPRLTDELNDLAGHTLDDL" FT CDS 74528..74866 FT /transl_table=11 FT /locus_tag="Rv0665" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0665, (MTCI376.11c), len: 112 aa. Conserved FT hypothetical protein, similar to Rv0627 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 FT aa), and showing similarity with Rv0595c." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:O06774" FT /protein_id="CAB09381.1" FT /translation="MTEGEVGVGLLDTSVFIARESGGAIADLPERVALSVMTIGELQLG FT LLNAGDSATRSRRADTLALARTADQIPVSEAVMISLARLVADCRAAGVRRSVKLTDALI FT AATAEIKV" FT CDS 74863..75036 FT /transl_table=11 FT /locus_tag="Rv0666" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0666, (MTCI376.10c), len: 57 aa. Possible membrane FT protein; has hydrophobic stretch at aa 29-47." FT /db_xref="UniProtKB/TrEMBL:O06773" FT /protein_id="CAB09391.1" FT /translation="MTPRTDEGAAAPCLMPDVTMPVKRGDARGALGVGPALFVVSVSSS FT LVRARSCRCTAD" FT CDS 75534..79052 FT /transl_table=11 FT /gene="rpoB" FT /locus_tag="Rv0667" FT /product="DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB FT (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT)" FT /function="CATALYZES THE TRANSCRIPTION OF DNA INTO RNA FT USING THE FOUR RIBONUCLEOSIDE TRIPHOSPHATES AS SUBSTRATES FT [CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = N FT DIPHOSPHATE + {RNA}(N)]." FT /EC_number="2.7.7.6" FT /note="Rv0667, (MTCI376.08c), len: 1172 aa. rpoB, FT DNA-directed RNA polymerase, beta chain (EC 2.7.7.6) (see FT Miller et al., 1994; Ahmad et al., 2000), equivalent to FT P30760|RPOB_MYCLE|ML1891 DNA-directed RNA polymerase beta FT chain from Mycobacterium leprae (1178 aa). Also highly FT similar to others e.g. AAF60349.1|AF242549_1|AF242549 FT DNA-dependent RNA polymerase beta subunit from FT Amycolatopsis mediterranei (1167 aa); CAB77428.1|AL160431 FT DNA-directed RNA polymerase beta chain from Streptomyces FT coelicolor (1161 aa); etc. Start site chosen on basis of FT RBS but alternative start exists at position 14359. BELONGS FT TO THE RNA POLYMERASE BETA CHAIN FAMILY." FT /db_xref="GOA:P0A680" FT /db_xref="InterPro:IPR007120" FT /db_xref="InterPro:IPR007121" FT /db_xref="InterPro:IPR007641" FT /db_xref="InterPro:IPR007642" FT /db_xref="InterPro:IPR007644" FT /db_xref="InterPro:IPR007645" FT /db_xref="InterPro:IPR010243" FT /db_xref="InterPro:IPR015712" FT /db_xref="InterPro:IPR019462" FT /db_xref="UniProtKB/Swiss-Prot:P0A680" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09390.1" FT /translation="MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVP FT GLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDP FT RFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIIN FT GTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDR FT KRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPP FT TKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLV FT RLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMT FT TQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLS FT RERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGV FT VSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVS FT PRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDV FT VVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQ FT VIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDA FT RDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEE FT RLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKR FT KISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHL FT GWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPN FT RDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQ FT QPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIP FT EPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESA FT SVEDLA" FT CDS 79097..83047 FT /transl_table=11 FT /gene="rpoC" FT /locus_tag="Rv0668" FT /product="DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC FT (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' FT SUBUNIT)." FT /function="CATALYZES THE TRANSCRIPTION OF DNA INTO RNA FT USING THE FOUR RIBONUCLEOSIDE TRIPHOSPHATES AS SUBSTRATES FT [CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = N FT DIPHOSPHATE + {RNA}(N)]." FT /EC_number="2.7.7.6" FT /note="Rv0668, (MTCI376.07c), len: 1316 aa. rpoC, FT DNA-directed RNA polymerase, beta' chain (EC 2.7.7.6) (see FT Miller et al., 1994), equivalent to FT P30761|RPOC_MYCLE|ML1890|S31146 DNA-directed RNA polymerase FT (EC 2.7.7.6) beta' chain from Mycobacterium leprae (1316 FT aa), FASTA scores: opt: 8295, E(): 0, (95.6% identity in FT 1316 aa overlap). Also highly similar to others e.g. FT CAB77429.1|AL160431 DNA-directed RNA polymerase beta' chain FT (fragment) from Streptomyces coelicolor (1059 aa); FT P37871|RPOC_BACSU from Bacillus subtilis (1199 aa), FASTA FT scores: opt: 2367, E(): 0, (52.9 identity in 1317 aa FT overlap); etc. BELONGS TO THE RNA POLYMERASE BETA' CHAIN FT FAMILY." FT /db_xref="GOA:P0A674" FT /db_xref="InterPro:IPR000722" FT /db_xref="InterPro:IPR006592" FT /db_xref="InterPro:IPR007066" FT /db_xref="InterPro:IPR007080" FT /db_xref="InterPro:IPR007081" FT /db_xref="InterPro:IPR007083" FT /db_xref="InterPro:IPR012754" FT /db_xref="UniProtKB/Swiss-Prot:P0A674" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09389.1" FT /translation="MLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDG FT LFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHI FT WYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKAVE FT DQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGEREMRQIRDRAQRELDRLEDI FT WSTFTKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVI FT RNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDL FT NDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPL FT KSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMK FT RLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLV FT EGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAM FT PRLDMVTGLYYLTTEVPGDTGEYQPASGDHPETGVYSSPAEAIMAADRGVLSVRAKIKV FT RLTQLRPPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQA FT AIINDLAERYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERA FT DKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIVDSGATGNFT FT QTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGARKGLADTALRTADSG FT YLTRRLVDVSQDVIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYARTLGTDAV FT DEAGNVIVERGQDLGDPEIDALLAAGITQVKVRSVLTCATSTGVCATCYGRSMATGKLV FT DIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEARVPRGKAPIAD FT VTGRVRLEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEV FT GQQLMEGSADPHEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVT FT IIDSGSTEFLPGSLIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLATDSWLSAAS FT FQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRNIAVQPTEEARAAAYT FT IPSYEDQYYSPDFGAATGAAVPLDDYGYSDYR" FT CDS complement(83411..85324) FT /transl_table=11 FT /locus_tag="Rv0669c" FT /product="POSSIBLE HYDROLASE" FT /function="UNKNOWN; HYDROLYTIC ENZYME PROBABLY INVOLVED IN FT CELLULAR METABOLISM." FT /EC_number="3.-.-.-" FT /note="Rv0669c, (MTCI376.05), len: 637 aa. Possible FT hydrolase (EC 3.-.-.-), highly similar to various FT hydrolases (N-terminus shorter) e.g. BAA88409.1|AB028646 FT alkaline ceramidase from Pseudomonas aeruginosa (670 aa,) FT FASTA scores: opt: 1490, E(): 0, (41.2% identity in 651 aa FT overlap); NP_063946.1|NM_019893 mitochondrial ceramidase FT from Homo sapiens (761 aa); P_446098.1|NM_053646 FT N-acylsphingosine amidohydrolase 2 from Rattus norvegicus FT (761 aa); BAB09641.1|AB016885 neutral ceramidase from FT Arabidopsis thaliana (705 aa); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:O06769" FT /db_xref="InterPro:IPR006823" FT /db_xref="UniProtKB/TrEMBL:O06769" FT /protein_id="CAB09388.1" FT /translation="MLSVGRGIADITGEAADCGMLGYGKSDQRTAGIHQRLRSRAFVFR FT DDSQDGDARLLLIVAELPLPMQNVNEEVLRRLADLYGDTYSEQNTLITATHTHAGPGGY FT CGYLLYNLTTSGFRPATFAAIVDGIVESVEHAHADVAPAEVSLSHGELYGASINRSPSA FT FDRNPPADKAFFPKRVDPHTTLVRIDRGEATVGVIHFFATHGTSMTNRNHLISGDNKGF FT AAYHWERTVGGADYLAGQPDFIAAFAQTNPGDMSPNVDGPLSPEAPPDREFDNTRRTGL FT CQFEDAFTQLSGATPIGAGIDARFTYVDLGSVLVRGEYTPDGEERRTGRPMFGAGAMAG FT TDEGPGFHGFRQGRNPFWDRLSRAMYRLARPTAAAQAPKGIVMPARLPNRIHPFVQEIV FT PVQLVRIGRLYLIGIPGEPTIVAGLRLRRMVASIVGADLADVLCVGYTNAYIHYVTTPE FT EYLEQRYEGGSTLFGRWELCALMQTVAELAEAMRDGRPVTLGRRPRPTRELSWVRGAPA FT DAGSFGAVIAEPSATYRPGQAVEAVFVSALPNNDLRRGGTYLEVVRREGASWVRIADDG FT DWATSFRWQRQGRAGSHVSIRWDVPGDTTPGQYRIVHHGTARDRNGMLTAFSATTREFT FT VV" FT misc_feature complement(85247..85270) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 85519..86277 FT /transl_table=11 FT /gene="end" FT /locus_tag="Rv0670" FT /standard_name="nfo" FT /product="PROBABLE ENDONUCLEASE IV END FT (ENDODEOXYRIBONUCLEASE IV) (APURINASE)" FT /function="INVOLVED IN BASE EXCISION REPAIR. ENDONUCLEASE FT IV PLAYS A ROLE IN DNA REPAIR. IT CLEAVES PHOSPHODIESTER FT BONDS AT APURINIC OR APYRIMIDINIC SITES (AP SITES) TO FT PRODUCE NEW 5' ENDS THAT ARE BASE-FREE DEOXYRIBOSE FT 5-PHOSPHATE RESIDUES [CATALYTIC ACTIVITY: Endonucleolytic FT cleavage to 5'-phosphooligonucleotide end-products]." FT /EC_number="3.1.21.2" FT /note="Rv0670, (MTCI376.04c), len: 252 aa. Probable end FT (alternate gene name: nfo), endonuclease IV (apurinase) (EC FT 3.1.21.2) (see citation below), equivalent to FT END_MYCLE|P30770|NFO|ML1889 probable endonuclease IV FT (apurinase) from Mycobacterium leprae (252 aa), FASTA FT scores: opt: 1463, E(): 0, (85.6% identity in 250 aa FT overlap). Also similar to others e.g. FT Q9S2N2|END4_STRCO|NFO|SC6E10.05 PROBABLE ENDONUCLEASE IV FT from Streptomyces coelicolor (294 aa); etc. Contains FT PS00729 AP endonucleases family 2 signatures 1 and 2 FT (PS00729, and PS00730). BELONGS TO THE AP ENDONUCLEASES FT FAMILY 2. COFACTOR: BINDS 3 ZINC IONS." FT /db_xref="GOA:P63535" FT /db_xref="InterPro:IPR001719" FT /db_xref="InterPro:IPR012307" FT /db_xref="InterPro:IPR013022" FT /db_xref="InterPro:IPR018246" FT /db_xref="UniProtKB/Swiss-Prot:P63535" FT /protein_id="CAA17467.1" FT /translation="MLIGSHVSPTDPLAAAEAEGADVVQIFLGNPQSWKAPKPRDDAAA FT LKAATLPIYVHAPYLINLASANNRVRIPSRKILQETCAAAADIGAAAVIVHGGHVADDN FT DIDKGFQRWRKALDRLETEVPVYLENTAGGDHAMARRFDTIARLWDVIGDTGIGFCLDT FT CHTWAAGEALTDAVDRIKAITGRIDLVHCNDSRDEAGSGRDRHANLGSGQIDPDLLVAA FT VKAAGAPVICETADQGRKDDIAFLRERTGS" FT misc_feature 85684..85710 FT /note="PS00729 AP endonucleases family 2 signature 1" FT misc_feature 85990..86013 FT /note="PS00730 AP endonucleases family 2 signature 2" FT CDS 86309..87151 FT /transl_table=11 FT /gene="lpqP" FT /locus_tag="Rv0671" FT /product="POSSIBLE CONSERVED LIPOPROTEIN LPQP" FT /function="UNKNOWN" FT /note="Rv0671, (MTCI376.03c), len: 280 aa. Possible lpqP, FT conserved lipoprotein, similar to U00012|B1308_F2_43|Q49658 FT from Mycobacterium leprae (302 aa), FASTA scores: opt: 449, FT E(): 2.4e-22, (37.6% identity in 242 aa overlap). Also FT highly similar to lpqC|Rv3298c|MTCY71.38c PUTATIVE FT LIPOPROTEIN from Mycobacterium tuberculosis (304 aa). Also FT similar to a large variety of proteins including various FT esterases and poly(3-hydroxyalkanoate) depolymerases, e.g. FT NP_249234.1|NC_002516 hypothetical protein from Pseudomonas FT aeruginosa (322 aa); C-terminus of FT AAD45376.1|AF164516_1|AF164516 cinnamoyl ester hydrolase FT EstA from Piromyces equi (536 aa); part of FT P52090|PHA1_PSELE POLY(3-HYDROXYALKANOATE) DEPOLYMERASE C FT PRECURSOR from Pseudomonas lemoignei (414 aa); FT CAC10310.1|AL442629 putative secreted protein from FT Streptomyces coelicolor (348 aa); etc. Has a 17 aa signal FT sequence and contains appropriately positioned (PS00013) FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="GOA:O86367" FT /db_xref="UniProtKB/TrEMBL:O86367" FT /protein_id="CAA17468.1" FT /translation="MLRRVAILLAAVLAFAGCSGGTRLAAGFGNGNSVHTLDVDGAGRS FT YRLYKPVGLPSSAPLVVMLHGGFGSAKQAERSYGWDELADSEKFLVAYPDGYHRAWNAN FT GGGCCGRPAREGVDDIGFVRAVVADIANNVSIDPARVYVTGMSNGAIMSYTLACNTSIF FT AAIGVVSGTQLDPCQSPRPVSVIHIHGTADPLVRYHGGPGAGFARIDGPPVPDLNAFWR FT EVNRCGALDTTTEGPVTTSGATCADNRRVVLLTVDDAGHRWPSFATQTLWRFFAAHFR" FT misc_feature 86330..86362 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 87211..88839 FT /transl_table=11 FT /gene="fadE8" FT /locus_tag="Rv0672" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE8" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv0672, (MTCI376.02c), len: 545 aa. Probable fadE8, FT acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to FT many e.g. CAC33951.1|AL589708 putative acyl-CoA FT dehydrogenase from Streptomyces coelicolor (557 aa); FT P33224|AIDB_ECOLI|B4187 aidb protein (ACYL-COA FT DEHYDROGENASES FAMILY) from Escherichia coli strain K12 FT (546 aa), FASTA scores: opt: 1369, E(): 0, (44.1% identity FT in 524 aa overlap); etc. Also similar to several other M. FT tuberculosis proteins e.g. Rv0154cRv0154c|MTCI5.28c FASTA FT score: (26.3% identity in 342 aa overlap); etc. Contains FT acyl-CoA dehydrogenases signature 2 (PS00073). BELONG TO FT THE ACYL-CoA DEHYDROGENASES FAMILY." FT /db_xref="GOA:O86368" FT /db_xref="InterPro:IPR006089" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006091" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="UniProtKB/TrEMBL:O86368" FT /protein_id="CAA17469.1" FT /translation="MSDTHVVTNQVPPLENYNPASSPVLIEALIQEGGQWGLDEVNEVG FT AISASCQAQRWGELADRNRPILHTHDAYGYRVDEVEYDPAYHELMRTAITHGMHAAPWA FT DDRPGAHVVRAAKTSVWTVEPGHICPISMTYAVVPALRYNSELAAVYEPLLTSREYDPE FT LKPATTKAGITAGMSMTEKQGGSDVRAGTTQATPNADGSYSLTGHKWFTSAPMCDIFLV FT LAQAPDGLSCFLLPRVLPDGTRNRMFLQRLKDKLGNHANASSEVEYDGAVAWLVGEEGR FT GVPTIIEMVNLTRLDCALGSATSMRTGLTRAVHHAQHRKAFGAYLIDQPLMRNVLADLA FT VEAEAATIVAMRMAGATDNAVRGNETEALLRRIGLAAAKYWVCKRSTAHAAEALECLGG FT NGYVEDSGMPRLYREAPLMGIWEGSGNVSALDTLRAMATRPACVEVLFDELARSAGQDP FT RLDGHVERLRPQLGDLDTIGYRARKIAEDICLALQGSLLVRHGHPAVAEAFLATRLGGQ FT WGGAYGTMPAGLDLAPILERALVKG" FT misc_feature 88393..88452 FT /note="PS00073 Acyl-CoA dehydrogenases signature 2" FT CDS 88850..89788 FT /transl_table=11 FT /gene="echA4" FT /locus_tag="Rv0673" FT /product="POSSIBLE ENOYL-CoA HYDRATASE ECHA4 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv0673, (MTCI376.01c, MTV040.01), len: 312 aa. FT Possible echA4, enoyl-CoA hydratase (EC 4.2.1.17), showing FT similarity with others e.g. NP_419216.1|NC_002696 enoyl-CoA FT hydratase/isomerase family protein from Caulobacter FT crescentus (256 aa); Q52995|ECHH_RHIME PROBABLE ENOYL-CoA FT HYDRATASE from Sinorhizobium meliloti (257 aa), FASTA FT scores: opt: 210, E(): 1.2e-06, (27.9% identity in 280 aa FT overlap); etc. Also similar to other enoyl-CoA hydratases FT from Mycobacterium tuberculosis e.g. FT P95279|MTCY09F9.29|ECHA13|Rv1935c|MTCY09F9.29 ENOYL-COA FT HYDRATASE (318 aa), FASTA score: (27.1% identity in 280 aa FT overlap); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop)." FT /db_xref="GOA:O86369" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:O86369" FT /protein_id="CAA17470.1" FT /translation="MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLE FT LSALVERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVLDGKTQA FT VNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGYCVAGGTDIALHADQVIA FT AADAKIGYPPTRVWGVPAAGLWAHRLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPEPA FT DLDERTERLVARIAALPVNQLIMVKLALNSALLQQGVATSRMVSTVFDGAARHTPEGHA FT FVADAVEHGFRDAVRRRDEPFGDYGRQASRV" FT misc_feature 89132..89155 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 89791..90513 FT /transl_table=11 FT /locus_tag="Rv0674" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0674, (MTV040.02), len: 240 aa. Conserved FT hypothetical protein, highly similar to AC13063.1|AL445503 FT conserved hypothetical protein from Streptomyces coelicolor FT (268 aa); and similar to NP_438100.1|NC_003078 putative FT regulator of phenylacetic acid degradation ArsR family FT protein from Sinorhizobium meliloti (306 aa) and other FT proteins e.g. AB011837|AB011837_13 hypothetical protein FT from Bacillus halodurans (298 aa), FASTA scores: opt: 148, FT E(): 0.0081, (25.1% identity in 235 aa overlap); etc. FT TBparse score is 0.915." FT /db_xref="InterPro:IPR012906" FT /db_xref="InterPro:IPR013225" FT /db_xref="UniProtKB/TrEMBL:O53782" FT /protein_id="CAA17457.1" FT /translation="MPAMTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVAL FT TRMVGAGDLVRSADGYRLSDRLLARQRRQDEAMRPRTRAWHGNWHMLIVTSIGTDARTR FT AALRTCMHHKRFGELREGVWMRPDNLDLDLESDVAARVRMLTARDEAPADLAGQLWDLS FT GWTEAGHRLLGDMAAATDMPGRFVVAAAMVRHLLTDPMLPAELLPADWPGAGLRAAYHD FT FATAMAKRRDATQLLEVT" FT CDS 90510..91301 FT /transl_table=11 FT /gene="echA5" FT /locus_tag="Rv0675" FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA5 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv0675, (MTV040.03), len: 263. Probable echA5, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to several e.g. FT NP_252116.1|NC_002516 probable enoyl FT CoA-hydratase/isomerase from Pseudomonas aeruginosa (256 FT aa); Q20376 PROTEIN SIMILAR TO ENOYL-CoA HYDRATASE from FT Caenorhabditis elegans (258 aa), FASTA scores: opt: 697, FT E(): 0, (47.3% identity in 245 aa overlap); etc. Also FT similar to others from Mycobacterium tuberculosis e.g. FT Z92669|MTCY8D5_17 (262 aa), FASTA scores: opt: 493, E(): FT 3.6e-25, (39.1% identity in 243 aa overlap); etc. TBparse FT score is 0.904." FT /db_xref="GOA:Q7D9G0" FT /db_xref="InterPro:IPR001753" FT /db_xref="InterPro:IPR018376" FT /db_xref="UniProtKB/TrEMBL:Q7D9G0" FT /protein_id="CAE55310.1" FT /translation="MSDLVRVERKGRVTTVILNRPASRNAVNGPTAAALCAAFEQFDRD FT DAASVAVLWGAGGTFCAGADLKAFGTPEANSVHRTGPGPMGPSRMMLSKPVIAAVSGYA FT VAGGLELALWCDLRVAEEDAVFGVFCRRWGVPLIDGGTVRLPRLIGHSRAMDMILTGRG FT VPADEALAMGLANRVVPKGQARQAAEELAAQLAALPQQCLRSDRLSALHQWGLPESAAL FT DLEFASIARVAGEALEGARRFAAGAGRHGAPAPRAEQGDTL" FT misc_feature 90798..90860 FT /note="PS00166 Enoyl-CoA hydratase/isomerase signature" FT CDS complement(91313..94207) FT /transl_table=11 FT /gene="mmpL5" FT /locus_tag="Rv0676c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL5" FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /note="Rv0676c, (MTV040.04c), len: 964 aa. Probable mmpL5, FT conserved transmembrane transport protein (see Tekaia et FT al., 1999), member of RND superfamily, highly similar to FT other Mycobacterial proteins e.g. MTV037_14, MTCY98_8, FT MTCY20G9_34, MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, FT etc. Also similar to other Mycobacterial mmpl proteins e.g. FT P54881|MML4_MYCLE PUTATIVE MEMBRANE PROTEIN MMPL4 from FT Mycobacterium leprae (959 aa), FASTA scores: opt: 3991, FT E(): 0, (62.8% identity in 933 aa overlap); etc. BELONGS TO FT THE MMPL FAMILY. TBparse score is 0.884." FT /db_xref="GOA:O53784" FT /db_xref="InterPro:IPR004707" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/Swiss-Prot:O53784" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17459.1" FT /translation="MIVQRTAAPTGSVPPDRHAARPFIPRMIRTFAVPIILGWLVTIAV FT LNVTVPQLETVGQIQAVSMSPDAAPSMISMKHIGKVFEEGDSDSAAMIVLEGQRPLGDA FT AHAFYDQMIGRLQADTTHVQSLQDFWGDPLTATGAQSSDGKAAYVQVKLAGNQGESLAN FT ESVEAVKTIVERLAPPPGVKVYVTGSAALVADQQQAGDRSLQVIEAVTFTVIIVMLLLV FT YRSIITSAIMLTMVVLGLLATRGGVAFLGFHRIIGLSTFATNLLVVLAIAAATDYAIFL FT IGRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYFQTLGVPLA FT IGMVIVVAAALTLGPAIIAVTSRFGKLLEPKRMARVRGWRKVGAAIVRWPGPILVGAVA FT LALVGLLTLPGYRTNYNDRNYLPADLPANEGYAAAERHFSQARMNPEVLMVESDHDMRN FT SADFLVINKIAKAIFAVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQD FT LTARMLEQVNDIQSNIDQMERMHSLTQQMADVTHEMVIQMTGMVVDVEELRNHIADFDD FT FFRPIRSYFYWEKHCYDIPVCWSLRSVFDTLDGIDVMTEDINNLLPLMQRLDTLMPQLT FT AMMPEMIQTMKSMKAQMLSMHSTQEGLQDQMAAMQEDSAAMGEAFDASRNDDSFYLPPE FT VFDNPDFQRGLEQFLSPDGHAVRFIISHEGDPMSQAGIARIAKIKTAAKEAIKGTPLEG FT SAIYLGGTAAMFKDLSDGNTYDLMIAGISALCLIFIIMLITTRSVVAAAVIVGTVVLSL FT GASFGLSVLIWQHILGIELHWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGII FT RAMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSIA FT ALLGKWFWWPQVVRQRPIPQPWPSPASARTFALV" FT CDS complement(94204..94632) FT /transl_table=11 FT /gene="mmpS5" FT /locus_tag="Rv0677c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN MMPS5" FT /function="UNKNOWN" FT /note="Rv0677c, (MTV040.05c), len: 142 aa. Possible mmpS5, FT conserved membrane protein (see Tekaia et al., 1999), FT highly similar to other Mycobacterial proteins e.g. FT P54880|MMS4_MYCLE PUTATIVE MEMBRANE PROTEIN from FT Mycobacterium leprae (154 aa), FASTA scores: opt: 443, E(): FT 1.4e-23, (47.1% identity in 155 aa overlap); etc. Also FT similar to others from Mycobacterium tuberculosis. BELONGS FT TO THE MMPS FAMILY. TBparse score is 0.901." FT /db_xref="GOA:P65380" FT /db_xref="InterPro:IPR008693" FT /db_xref="UniProtKB/Swiss-Prot:P65380" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17460.1" FT /translation="MIGTLKRAWIPLLILVVVAIAGFTVQRIRTFFGSEGILVTPKVFA FT DDPEPFDPKVVEYEVSGSGSYVNINYLDLDAKPQRIDGAALPWSLTLKTTAPSAAPNIL FT AQGDGTSITCRITVDGEVKDERTATGVDALTYCFVKSA" FT CDS 94717..95214 FT /transl_table=11 FT /locus_tag="Rv0678" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0678, (MTV040.06), len: 165 aa. Conserved FT hypothetical protein, showing weak similarity with FT AL049754|SCH10_10 hypothetical protein from Streptomyces FT coelicolor (152 aa), FASTA scores: opt: 149, E(): 0.0018, FT (22.9% identity in 140 aa overlap). TBparse score is FT 0.910." FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:O53786" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17461.1" FT /translation="MSVNDGVDQMGAEPDIMEFVEQMGGYFESRSLTRLAGRLLGWLLV FT CDPERQSSEELATALAASSGGISTNARMLIQFGFIERLAVAGDRRTYFRLRPNAFAAGE FT RERIRAMAELQDLADVGLRALGDAPPQRSRRLREMRDLLAYMENVVSDALGRYSQRTGE FT DD" FT CDS complement(95270..95767) FT /transl_table=11 FT /locus_tag="Rv0679c" FT /product="CONSERVED HYPOTHETICAL THREONINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv0679c, (MTV040.07c), len: 165 aa. Conserved FT hypothetical Thr-rich protein, similar in part to FT neighboring ORF Rv0680c (124 aa), FASTA score: (35.1% FT identity in 131 aa overlap); and Rv0314c (220 aa). Contains FT probable N-terminal signal sequence. TBparse score is FT 0.894." FT /db_xref="UniProtKB/TrEMBL:O53787" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17462.1" FT /translation="MVEKPLRADRATHSRLATFALALAAAALPLAGCSSTANPPAATTT FT PATATTTTATSGPTAAPTVTTGESTTASIQIGDMLTYGSIGTTATLDCADGKSLNVAGS FT DNTLTVNGTCETVTVGGANNKIAFDRIDERLVVVGLDNTVTYKNGDPTIDNLGAGNRIN FT KE" FT CDS complement(95769..96143) FT /transl_table=11 FT /locus_tag="Rv0680c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0680c, (MTV040.08c), len: 124 aa. Possible FT conserved transmembrane protein, showing similarity with FT C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved FT hypothetical protein from Mycobacterium tuberculosis (220 FT aa), FASTA scores: opt: 175, E(): 2.2e-05, (31.4% identity FT in 102 aa overlap). Also some similarity to upstream ORF FT Rv0679c|MTV040.07c CONSERVED HYPOTHETICAL THREONINE RICH FT PROTEIN (124 aa), FASTA score: (35.1% identity in 131 aa FT overlap). Contains probable N-terminal signal sequence. FT TBparse score is 0.877." FT /db_xref="GOA:O53788" FT /db_xref="UniProtKB/TrEMBL:O53788" FT /protein_id="CAA17463.1" FT /translation="MKWNTVAASLAAGVITIAVALAAPPPAAHAKNGDTHVTGQGIERT FT LDCNESTLLVNGTQNIVTALGTCWAVTVMGSSNTVVADTIINDITVYGWDETVFFRNGD FT PFIWDRGRELGMVNRLQRVG" FT CDS 96448..97038 FT /transl_table=11 FT /locus_tag="Rv0681" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0681, (MTV040.09), len: 196 aa. Probable FT transcription regulator, TetR family, similar to others and FT especially many tetracycline repressors e.g. T34657 FT probable transcription regulator from Streptomyces FT coelicolor (189 aa); FT AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator FT from Bacillus subtilis (191 aa), FASTA scores: opt: 213, FT E(): 1.6e-07, (28.8% identity in 153 aa overlap); FT P09164|TER4_ECOLI TETRACYCLINE REPRESSOR PROTEIN from FT Escherichia coli (217 aa), FASTA scores: opt: 145, E(): FT 0.0068, (39.0% identity in 59 aa overlap); etc. Contains FT helix-turn-helix motif at aa 28-49 (Score 1020, +2.66 SD). FT TBparse score is 0.897." FT /db_xref="GOA:O53789" FT /db_xref="InterPro:IPR001647" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:O53789" FT /protein_id="CAA17464.1" FT /translation="MARPAKLSRESIVEGALTFLDREGWDSLTINALATQLGTKGPSLY FT NHVDSLEDLRRAVRIRVIDDIITMLNRVGAGRARDDAVLVMAGAYRSYAHHHPGRYSAF FT TRMPLGGDDPEYTAATRGAAAPVIAVLSSYGLDGEQAFYAALEFWSALHGFVLLEMTGV FT MDDIDTDAVFTDMVLRLAAGMERRTTHGGTAST" FT CDS 97287..97661 FT /transl_table=11 FT /gene="rpsL" FT /locus_tag="Rv0682" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S12 RPSL" FT /function="PROTEIN S12 IS INVOLVED IN THE TRANSLATION FT INITIATION STEP." FT /note="Rv0682, (MTV040.10), len: 124 aa. Probable rpsL, 30S FT ribosomal protein S12 (see citations below), equivalent to FT others from Mycobacteria e.g. P41195|RS12_MYCSM 30S FT RIBOSOMAL PROTEIN S12 from Mycobacterium smegmatis (124 FT aa); P51999|RS12_MYCAV 30S RIBOSOMAL PROTEIN S12 from FT Mycobacterium avium (124 aa); etc. Also highly similar to FT others from other organisms e.g. P97222|RS12_STRCO 30S FT RIBOSOMAL PROTEIN S12 from Streptomyces roseosporus, FT lividans and coelicolor (123 aa); etc. Contains PS00055 FT Ribosomal protein S12 signature. BELONGS TO THE S12P FAMILY FT OF RIBOSOMAL PROTEINS. TBparse score is 0.893." FT /db_xref="GOA:P41196" FT /db_xref="InterPro:IPR005679" FT /db_xref="InterPro:IPR006032" FT /db_xref="InterPro:IPR012340" FT /db_xref="InterPro:IPR016027" FT /db_xref="UniProtKB/Swiss-Prot:P41196" FT /protein_id="CAA17465.1" FT /translation="MPTIQQLVRKGRRDKISKVKTAALKGSPQRRGVCTRVYTTTPKKP FT NSALRKVARVKLTSQVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDT FT QGVKNRKQARSRYGAKKEKG" FT misc_feature 97413..97436 FT /note="PS00055 Ribosomal protein S12 signature" FT CDS 97661..98131 FT /transl_table=11 FT /gene="rpsG" FT /locus_tag="Rv0683" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S7 RPSG" FT /function="PROTEIN S7 BINDS SPECIFICALLY TO PART OF THE 3' FT END OF 16S RIBOSOMAL RNA." FT /note="Rv0683, (MTV040.11), len: 156 aa. Probable rpsG, 30S FT ribosomal protein S7 (see citation below), equivalent to FT others from Mycobacteria e.g. P41193|RS7_MYCSM 30S FT RIBOSOMAL PROTEIN S7 from Mycobacterium smegmatis (156 aa), FT FASTA scores: opt: 986, E(): 0, (96.2% identity in 156 aa FT overlap); Q53539|RS7_MYCBO 30S RIBOSOMAL PROTEIN S7 from FT Mycobacterium bovis (156 aa); etc. Also highly similar to FT others e.g. Q9L0K4|RS7_STRCO 30S RIBOSOMAL PROTEIN S7 from FT Streptomyces coelicolor (156 aa); etc. Contains PS00052 FT Ribosomal protein S7 signature. BELONGS TO THE S7P FAMILY FT OF RIBOSOMAL PROTEINS. TBparse score is 0.907." FT /db_xref="GOA:P41194" FT /db_xref="InterPro:IPR000235" FT /db_xref="InterPro:IPR005717" FT /db_xref="InterPro:IPR020606" FT /db_xref="UniProtKB/Swiss-Prot:P41194" FT /protein_id="CAA17466.1" FT /translation="MPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLKGKKSLAERIVYG FT ALEQARDKTGTDPVITLKRALDNVKPALEVRSRRVGGATYQVPVEVRPDRSTTLALRWL FT VGYSRQRREKTMIERLANEILDASNGLGASVKRREDTHKMAEANRAFAHYRW" FT misc_feature 97718..97798 FT /note="PS00052 Ribosomal protein S7 signature" FT CDS 98212..100317 FT /transl_table=11 FT /gene="fusA1" FT /locus_tag="Rv0684" FT /standard_name="fusA" FT /product="PROBABLE ELONGATION FACTOR G FUSA1 (EF-G)" FT /function="THIS PROTEIN PROMOTES THE GTP-DEPENDENT FT TRANSLOCATION OF THE NASCENT PROTEIN CHAIN FROM THE A-SITE FT TO THE P-SITE OF THE RIBOSOME." FT /note="Rv0684, (MTV040.12, MTCY210.01), len: 701 aa. FT Probable fusA1, elongation factor G, equivalent to FT P30767|EFG_MYCLE|S31150 translation elongation factor EF-G FT from Mycobacterium leprae (701 aa), FASTA scores: opt: FT 2521, E(): 0, (88.2% identity in 432 aa overlap). Also FT highly similar to others e.g. CAB81852.1|AL161691 FT elongation factor G from Streptomyces coelicolor (708 aa); FT etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) FT and PS00301 GTP-binding elongation factors signature. FT BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, FT EF-G/EF-2 SUBFAMILY. TBparse score is 0.872. Note that FT previously known as fusA." FT /db_xref="GOA:P0A556" FT /db_xref="InterPro:IPR000640" FT /db_xref="InterPro:IPR000795" FT /db_xref="InterPro:IPR004161" FT /db_xref="InterPro:IPR004540" FT /db_xref="InterPro:IPR005225" FT /db_xref="InterPro:IPR005517" FT /db_xref="InterPro:IPR009000" FT /db_xref="InterPro:IPR009022" FT /db_xref="InterPro:IPR014721" FT /db_xref="InterPro:IPR020568" FT /db_xref="UniProtKB/Swiss-Prot:P0A556" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55311.1" FT /translation="MAQKDVLTDLSRVRNFGIMAHIDAGKTTTTERILYYTGINYKIGE FT VHDGAATMDWMEQEQERGITITSAATTTFWKDNQLNIIDTPGHVDFTVEVERNLRVLDG FT AVAVFDGKEGVEPQSEQVWRQADKYDVPRICFVNKMDKIGADFYFSVRTMGERLGANAV FT PIQLPVGAEADFEGVVDLVEMNAKVWRGETKLGETYDTVEIPADLAEQAEEYRTKLLEV FT VAESDEHLLEKYLGGEELTVDEIKGAIRKLTIASEIYPVLCGSAFKNKGVQPMLDAVVD FT YLPSPLDVPPAIGHAPAKEDEEVVRKATTDEPFAALAFKIATHPFFGKLTYIRVYSGTV FT ESGSQVINATKGKKERLGKLFQMHSNKENPVDRASAGHIYAVIGLKDTTTGDTLSDPNQ FT QIVLESMTFPDPVIEVAIEPKTKSDQEKLSLSIQKLAEEDPTFKVHLDSETGQTVIGGM FT GELHLDILVDRMRREFKVEANVGKPQVAYKETIKRLVQNVEYTHKKQTGGSGQFAKVII FT NLEPFTGEEGATYEFESKVTGGRIPREYIPSVDAGAQDAMQYGVLAGYPLVNLKVTLLD FT GAYHEVDSSEMAFKIAGSQVLKKAAALAQPVILEPIMAVEVTTPEDYMGDVIGDLNSRR FT GQIQAMEERAGARVVRAHVPLSEMFGYVGDLRSKTQGRANYSMVFDSYSEVPANVSKEI FT IAKATGE" FT misc_feature 98269..98292 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 98371..98418 FT /note="PS00301 GTP-binding elongation factors signature" FT CDS 100548..101738 FT /transl_table=11 FT /gene="tuf" FT /locus_tag="Rv0685" FT /product="PROBABLE IRON-REGULATED ELONGATION FACTOR TU TUF FT (EF-TU)" FT /function="THIS PROTEIN PROMOTES THE GTP-DEPENDENT BINDING FT OF AMINOACYL-TRNA TO THE A-SITE OF RIBOSOMES DURING PROTEIN FT BIOSYNTHESIS." FT /note="Rv0685, (MTCY210.02), len: 396 aa. Probable tuf, FT iron-regulated elongation factor EF-Tu, equivalent to FT JC2262 translation elongation factor Tu from Mycobacterium FT leprae (396 aa). Also highly similar to others e.g. FT P42439|EFTU_CORGL ELONGATION FACTOR TU (EF-TU) from FT Corynebacterium glutamicum (396 aa); etc. Contains PS00017 FT ATP/GTP-binding site motif A, and PS00301 GTP-binding FT elongation factors signature. BELONGS TO THE GTP-BINDING FT ELONGATION FACTOR FAMILY, EF-TU/EF-1A SUBFAMILY." FT /db_xref="GOA:P0A558" FT /db_xref="InterPro:IPR000795" FT /db_xref="InterPro:IPR004160" FT /db_xref="InterPro:IPR004161" FT /db_xref="InterPro:IPR004541" FT /db_xref="InterPro:IPR005225" FT /db_xref="InterPro:IPR009000" FT /db_xref="InterPro:IPR009001" FT /db_xref="UniProtKB/Swiss-Prot:P0A558" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06471.1" FT /translation="MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNE FT TKAFDQIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGA FT ILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVDDEELLELVEMEVRELLAAQ FT EFDEDAPVVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVFTI FT TGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQGQAGDNVGLLL FT RGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDV FT TGVVTLPEGTEMVMPGDNTNISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKIIK" FT misc_feature 100602..100625 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 100704..100751 FT /note="PS00301 GTP-binding elongation factors signature" FT CDS 101876..102673 FT /transl_table=11 FT /locus_tag="Rv0686" FT /product="PROBABLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0686, (MTCY210.03), len: 265 aa. Probable membrane FT protein, with hydrophobic N-terminus. TBparse score is FT 0.908." FT /db_xref="UniProtKB/TrEMBL:P95032" FT /protein_id="CAB06472.1" FT /translation="MLARYIKMQLLVLLCGGLVGPIFLVVYFTLGLGSLMSWMFYVGLI FT ITVADVLVALALTNYGAKTAAKTAALERSGVLALAQITGLSETGTRINDQPLVKVHLHI FT SGPGITPFDTEDRVIASVTRLGNLTARKLVVLVNPATQQYLIDWERSALVNGLVPAQFT FT VAEDNKTYDLSGQTGPLMEILQILKANNVPLNRMVDIRSNPALRQQVQAVVRRAAERQA FT PAAEPASQGSIAERLAELESLRASGAVNAAEYESKRAQIISEI" FT CDS 102826..103653 FT /transl_table=11 FT /locus_tag="Rv0687" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0687, (MTCY210.04), len: 275 aa. Probable FT short-chain dehydrogenase/reductase (EC 1.-.-.-), highly FT similar to various dehydrogenases (generally SDR family) FT e.g. U17129|RSU17129_7 short-chain dehydrogenase from FT Rhodococcus erythropolis (275 aa), FASTA scores: opt: 1112, FT E(): 0, (61.2% identity in 268 aa overlap); MMU34072_2 FT steroid dehydrogenase from Musmus culus (260 aa), FASTA FT scores: opt: 390, E(): 2.2e-17, (34.1% identity in 267 aa FT overlap); etc. Also similar to MTV002_16|O33292|Rv2750 FT DEHYDROGENASE from Mycobacterium tuberculosis (272 aa). FT Contains PS00061 Short-chain alcohol dehydrogenase family FT signature. TBparse score is 0.920." FT /db_xref="GOA:P95033" FT /db_xref="HSSP:1NFF" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P95033" FT /protein_id="CAB06450.1" FT /translation="MSARGGSLHGRVAFVTGAARAQGRSHAVRLAREGADIVALDICAP FT VSGSVTYPPATSEDLGETVRAVEAEGRKVLAREVDIRDDAELRRLVADGVEQFGRLDIV FT VANAGVLGWGRLWELTDEQWETVIGVNLTGTWRTLRATVPAMIDAGNGGSIVVVSSSAG FT LKATPGNGHYAASKHALVALTNTLAIELGEFGIRVNSIHPYSVDTPMIEPEAMIQTFAK FT HPGYVHSFPPMPLQPKGFMTPDEISDVVVWLAGDGSGALSGNQIPVDKGALKY" FT misc_feature 103303..103389 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 103667..104887 FT /transl_table=11 FT /locus_tag="Rv0688" FT /product="PUTATIVE FERREDOXIN REDUCTASE" FT /function="FERREDOXINS ARE IRON-SULFUR PROTEINS THAT FT TRANSFER ELECTRONS IN A WIDE VARIETY OF METABOLIC FT REACTIONS." FT /EC_number="1.-.-.-" FT /note="Rv0688, (MTCY210.05), len: 406 aa. Putative FT ferredoxin reductase (EC 1.-.-.-), highly similar to others FT e.g. BAB55881.1|AB054975 ferredoxin reductase from FT Terrabacter sp. DBF63 (410 aa); CAC04223.1|AL391515 FT putative ferredoxin reductase from Streptomyces coelicolor FT (420 aa); PPU24215_8|Q51973 P-CUMATE DIOXYGENASE FERREDOXIN FT REDUCTASE SUBUNIT from Pseudomonas putida (402 aa), FASTA FT scores: opt: 738, E(): 0, (38.8% identity in 330 aa FT overlap); etc. Also similar to Rv0253 and Rv1869c from FT Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL FT TYPE FERREDOXIN FAMILY. TBparse score is 0.909." FT /db_xref="GOA:P95034" FT /db_xref="HSSP:1M6I" FT /db_xref="InterPro:IPR001327" FT /db_xref="InterPro:IPR004099" FT /db_xref="InterPro:IPR013027" FT /db_xref="InterPro:IPR016040" FT /db_xref="InterPro:IPR016156" FT /db_xref="UniProtKB/TrEMBL:P95034" FT /protein_id="CAB06451.1" FT /translation="MNAHVTSREGVNEFDDGIVIVGGGLAAARTAEQLRRAGYSGRLTI FT VSDEVHLPYDRPPLSKEVLRSEVDDVALKPREFYDEKDIALRLGSAAVSLDTGEQTVTL FT ADGTVLGYDELVIATGLVPRRIPSLPDLDGIRVLRSFDESMALRKHASAARHAVVVGAG FT FIGCEVAASLRGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRDEGVDVRTGVTVAEV FT RGKGHVDAVVLTDGTELPADLVVVGIGSTPATEWLEGSGVEVDNGVICDKAGRTSAPNV FT WALGDVASWRDPMGHQARVEHWSNVADQARVVVPAMLGTDVPTGVVVPYFWSDQYDVKI FT QCLGEPHATDVVHLVEDDGRKFLAYYERDGVLVGVVGGGMAGKVMKVRGKIAAGAPIAE FT VLDQTQA" FT CDS complement(104884..105138) FT /transl_table=11 FT /locus_tag="Rv0689c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0689c, (MTCY210.06c), len: 84 aa. Hypothetical FT unknown protein. TBparse score is 0.879." FT /db_xref="UniProtKB/TrEMBL:P95035" FT /protein_id="CAB06452.1" FT /translation="MLGWTVKPGRVADGWQAPGVHLMARCSGPQPASERRADMDGGDID FT AAVARVRAAGALAEPSRQPDDMSAECADDQGARCHLGQL" FT CDS complement(105751..106800) FT /transl_table=11 FT /locus_tag="Rv0690c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0690c, (MTCY210.07c), len: 349 aa. Conserved FT hypothetical protein, showing similarity with FT NP_386956.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from FT Sinorhizobium meliloti (358 aa); NP_356573.1|NC_003063 FT AGR_L_1570p from Agrobacterium tumefaciens (346 aa); FT NP_421938.1|NC_002696 conserved hypothetical protein from FT Caulobacter crescentus (370 aa). TBparse score is 0.918." FT /db_xref="InterPro:IPR011200" FT /db_xref="UniProtKB/TrEMBL:P95036" FT /protein_id="CAB06453.1" FT /translation="MTGTEHLVHTLRSQGRVCTSSGSPMYRELLELVAADVESGGVFAS FT ILADQKGAPEGQAVPLRLLGGLHRMVLDGRAPVLRRWYPSTGGTWQAEAAWPDIVRTAT FT DQPESLRAALDRPPQTNEVGRSAALIGGLLIACLQFDLPIRLFEIGSSAGLNLRPDRYR FT YRYLGGEWGLADSPVRIDNAWLGELPPTATVRIVERHGYDIAPIDVTSPDGELNALSYI FT WPDQTDRLERLRGAIAVARNIPADLHRQAAHAAVAGMTLTDDALTVLWHSITWQYLPAD FT ERAAIRAGIDALAAQADAHCPFVHLTLEPAHQRPGAQIKYLVRMRSWPGGHARVLGECH FT PHGPPVTWQ" FT CDS complement(106797..107393) FT /transl_table=11 FT /locus_tag="Rv0691c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM" FT /note="Rv0691c, (MTCY210.08c), len: 198 aa. Probable FT transcriptional regulator, highly similar to FT AAC77476.1|U17129 unknown protein from Rhodococcus FT erythropolis (185 aa); and showing similarity with putative FT regulatory proteins eg STMTCREP_1|TCMR_STRGA|P39885 FT tetracenomycin c transcriptional repressor from FT Streptomyces glaucescens (226 aa), FASTA scores: opt: 178, FT E(): 8.5e-06, (27.9% identity in 201 aa overlap); etc. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop) and FT probable helix-turn helix motifs from aa 34-55 (Score 1100, FT +2.93 SD) and 151-172 (Score 1124, +3.02 SD). TBparse score FT is 0.934." FT /db_xref="GOA:P95037" FT /db_xref="InterPro:IPR001647" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:P95037" FT /protein_id="CAB06454.1" FT /translation="MPHESRVGRRRSTTPHHISDVAIELFAAHGFTDVSVDDIARAAGI FT ARRTLFRYYASKNAIPWGDFSTHLAQLQGLLDNIDSRIQLRDALRAALLAFNTFDESET FT IRHRKRMRVILQTPELQAYSMTMYAGWREVIAKFVARRSGGKTTDFMPQTVAWTMLGVA FT LSAYEHWLRDESVSLTEALGAAFDVVGAGLDRLNQ" FT misc_feature complement(106953..106976) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 107558..107887 FT /transl_table=11 FT /locus_tag="Rv0692" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0692, (MTCY210.09), len: 109 aa. Conserved FT hypothetical protein, highly similar to FT U17129|RSU17129_3|AAC77477.1 unknown protein from FT Rhodococcus erythropolis (95 aa), FASTA scores: opt: 393, FT E(): 8.8e-22, (68.2% identity in 88 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P95038" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06455.1" FT /translation="MWGLLTVPAPAQARRADSSEFDPDRGWRLHPQVAVRPEPFGALLY FT HFGTRKLSFLKNRTILAVVQTLADYPDIRSACRGAGVDDCDQDPYLHALSVLAGSNMLV FT PRQTT" FT CDS 107884..109059 FT /transl_table=11 FT /gene="pqqE" FT /locus_tag="Rv0693" FT /standard_name="pqqIII" FT /product="PROBABLE COENZYME PQQ SYNTHESIS PROTEIN E PQQE FT (COENZYME PQQ SYNTHESIS PROTEIN III)" FT /function="REQUIRED FOR COENZYME PYRROLO-QUINOLINE-QUINONE FT (PQQ) BIOSYNTHESIS." FT /note="Rv0693, (MTCY210.10), len: 391 aa. Probable pqqE FT (alternate gene name: pqqIII), coenzyme PQQ synthesis FT protein E, similar to others AE001109_9|O30258|PQQE FT COENZYME PQQ SYNTHESIS PROTEIN from Archaeoglobus fulgidus FT (375 aa), FASTA scores: E(): 1.6e-16, (28.1% identity in FT 377 aa overlap); PQQE_ACICA|P07782 coenzyme pqq synthesis FT protein e from Acinetobacter calcoaceticus (384 aa), FASTA FT scores: opt: 302, E(): 1.8e-12, (23.9% identity in 377 aa FT overlap); etc. Also similar to C-terminus of heme FT biosynthesis proteins e.g. O28270|AF2009 HEME BIOSYNTHESIS FT PROTEIN (NIRJ-2) from Archaeoglobus fulgidus (468 aa). Note FT that also highly similar to U17129|RSU17129_4|AAC77478.1 FT unknown protein from Rhodococcus erythropolis (405 aa), FT FASTA scores: opt: 1997, E(): 0, (73.3% identity in 390 aa FT overlap). COULD BELONG TO THE MOAA / NIFB / PQQE FAMILY. FT TBparse score is 0.919." FT /db_xref="GOA:P95039" FT /db_xref="InterPro:IPR006638" FT /db_xref="InterPro:IPR007197" FT /db_xref="InterPro:IPR017200" FT /db_xref="UniProtKB/TrEMBL:P95039" FT /protein_id="CAB06456.1" FT /translation="MTSPVPRLIEQFERGLDAPICLTWELTYACNLACVHCLSSSGKRD FT PGELSTRQCKDIIDELERMQVFYVNIGGGEPTVRPDFWELVDYATAHHVGVKFSTNGVR FT ITPEVATRLAATDYVDVQISLDGATAEVNDAIRGTGSFDMAVRALQNLAAAGFAGVKIS FT VVITRRNVAQLDEFATLASRYGATLRITRLRPSGRGTDVWADLHPTADQQVQLYDWLVS FT KGERVLTGDSFFHLAPLGQSGALAGLNMCGAGRVVCLIDPVGDVYACPFAIHDHFLAGN FT VLSDGGFQNVWKNSSLFRELREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPLDGPDPE FT CVQGHSEPALARERHLPRPRADHSRGRRVSKPVPLTLSMRPPKRPCNESPV" FT CDS 109062..110252 FT /transl_table=11 FT /gene="lldD1" FT /locus_tag="Rv0694" FT /product="POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) FT LLDD1" FT /function="INVOLVED IN RESPIRATION; CATALYZES CONVERSION OF FT LACTATE INTO PYRUVATE [CATALYTIC ACTIVITY: (S)-LACTATE + 2 FT FERRICYTOCHROME C = PYRUVATE + 2 FERROCYTOCHROME C]." FT /EC_number="1.1.2.3" FT /note="Rv0694, (MTCY210.11), len: 396 aa. Possible lldD1, FT L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar FT to NP_302368.1|NC_002677 L-lactate dehydrogenase from FT Mycobacterium leprae (414 aa). Also similar to others e.g. FT NP_384560.1|NC_003047 PUTATIVE L-LACTATE DEHYDROGENASE FT (CYTOCHROME) PROTEIN from Sinorhizobium meliloti (403 aa); FT NP_251072.1|NC_002516 L-lactate dehydrogenase from FT Pseudomonas aeruginosa (383 aa); P33232|LLDD_ECOLI FT L-lactate dehydrogenase (cytochrome) from Escherichia coli FT strain K12 (396 aa), FASTA scores: opt: 697, E(): 0, (34.5 FT identity in 380 aa overlap); etc; and also similar to other FT oxidoreductases. Note that also highly similar to FT RSU17129_5|AAC77479.1|U17129 unknown protein from FT Rhodococcus erythropolis (392 aa), FASTA scores: opt: 2006, FT E(): 0, (74.1% identity in 386 aa overlap). Also similar to FT lldD2|Rv1872c|MTCY180.46|MTCY359.01 POSSIBLE L-LACTATE FT DEHYDROGENASE (CYTOCHROME) from Mycobacterium tuberculosis FT (414 aa). BELONGS TO THE FMN-DEPENDENT ALPHA-HYDROXY ACID FT DEHYDROGENASES FAMILY. TBparse score is 0.918." FT /db_xref="GOA:P95040" FT /db_xref="HSSP:1GOX" FT /db_xref="InterPro:IPR000262" FT /db_xref="InterPro:IPR012133" FT /db_xref="InterPro:IPR013785" FT /db_xref="InterPro:IPR017934" FT /db_xref="UniProtKB/TrEMBL:P95040" FT /protein_id="CAB06457.1" FT /translation="MAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAF FT SELGFAPHVIGATDKRDLSTTVMGQEVSLPVIISPTGVQAVDPGGEVAVARAAAARGTV FT MGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSH FT GRDWGSPKIPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPF FT FAAYGEWMATPPPTWEDIGWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGN FT NLDGTPASIRALPAVSAAVGDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLA FT ANGQAGVENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV" FT CDS 110442..111197 FT /transl_table=11 FT /locus_tag="Rv0695" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0695, (MTCY210.12), len: 251 aa. Conserved FT hypothetical protein, similar to many creatinine FT amidohydrolases or hypothetical proteins e.g. FT NP_443048.1|NC_000911 creatinine amidohydrolase from FT Synechococcus sp. PCC 6803 (273 aa); NP_466169.1|NC_003210 FT protein similar to creatinine amidohydrolase from Listeria FT monocytogenes (249 aa); T35153|SC5A7.04c hypothetical FT protein from Streptomyces coelicolor (273 aa); etc. Note FT that highly similar to RSU17129_10|AAC77474.1|U17129 FT unknown protein from Rhodococcus erythropolis (230 aa), FT FASTA scores: opt: 693, E(): 0, (55.7% identity in 237 aa FT overlap)." FT /db_xref="InterPro:IPR003785" FT /db_xref="UniProtKB/TrEMBL:P95041" FT /protein_id="CAB06458.1" FT /translation="MNSSYHRRVPVVGELGSATSSQLPSTSPSIVIPLGSTEQHGPHLP FT LDTDTRIATAVARTVTARLHAEDLPIAQEEWLMAPAIAYGASGEHQRFAGTISIGTEAL FT TMLLVEYGRSAACWARRLVFVNGHGGNVGALTRAVGLLRAEGRDAGWCPCTCPGGDPHA FT GHTETSVLLHLSPADVRTERWRAGNRAPLPVLLPSMRRGGVAAVSETGVLGDPTTATAA FT EGRRIFAAMVDDCVRRVARWMPQPDGMLT" FT repeat_region 111194..111245 FT /note="52 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 111246..112658 FT /transl_table=11 FT /locus_tag="Rv0696" FT /product="PROBABLE MEMBRANE SUGAR TRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="2.-.-.-" FT /note="Rv0696, (MTCY210.13), len: 470 aa. Probable membrane FT sugar transferase (EC 2.-.-.-), similar (except in FT N-terminus) to NP_069157.1|NC_000917 glycosyl transferase FT from Archaeoglobus fulgidus (324 aa); NP_279985.1|NC_002607 FT rhamnosyl transferase from Halobacterium sp. NRC-1 (299 FT aa); NP_059113.1|NM_017417 polypeptide FT N-acetylgalactosaminyltransferase 8 from (637 aa). Note FT that also highly similar to P46370|YTH1_RHOER HYPOTHETICAL FT 55.3 KDA PROTEIN from Rhodococcus erythropolis (513 aa), FT FASTA scores: opt: 1514, E(): 0, (51.8% identity in 469 aa FT overlap). TBparse score is 0.924." FT /db_xref="GOA:P95042" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:P95042" FT /protein_id="CAB06459.1" FT /translation="MTATRLPDGFAVQVDRRVRVLGDGSALLGGSPTRLLRLAPAARGL FT LCDGRLKVRDEVSAELARILLDATVAHPRPPSGPSHRDVTVVIPVRNNASGLRRLVTSL FT RGLRVIVVDDGSACPVESDDFVGAHCDIEVLHHPHSKGPAAARNTGLAACTTDFVAFLD FT SDVTPRRGWLESLLGHFCDPTVALVAPRIVSLVEGENPVARYEALHSSLDLGQREAPVL FT PHSTVSYVPSAAIVCRSSAIRDVGGFDETMHSGEDVDLCWRLIEAGARLRYEPIALVAH FT DHRTQLRDWIARKAFYGGSAAPLAVRHPDKTAPLVISGGALMAWILMSIGTGLGRLASL FT VIAVLTGRRIARAMRCAETSFLDVLAVATRGLWAAALQLASAICRHYWPLALLAAILSR FT RCRRVVLIAAVVDGVVDWLRRREGADDDAEPIGPLTYLVLKRVDDLAYGAGLWYGVVRE FT RNIGALKPQIRT" FT CDS 112660..114099 FT /transl_table=11 FT /locus_tag="Rv0697" FT /product="PROBABLE DEHYDROGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0697, (MTCY210.14, unknown), len: 479 aa. Probable FT dehydrogenase (EC 1.-.-.-), highly similar to FT P30772|YTUR_MYCLE HYPOTHETICAL 24 kDa PROTEIN from FT Mycobacterium leprae (220 aa), FASTA scores: opt: 557, E(): FT 1.7e-28, (46.2% identity in 223 aa overlap). Also highly FT similar to P46371|YTH2_RHOER HYPOTHETICAL 53.0 KDA GMC-TYPE FT OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa); and FT similar to many dehydrogenases e.g. NP_250814.1|NC_002516 FT probable dehydrogenase from Pseudomonas aeruginosa (545 FT aa); BAA13145.1|D86622 FAD dependent L-sorbose FT dehydrogenase from Gluconobacter oxydans (531 aa); etc. FT Also similar to Rv1279 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis." FT /db_xref="GOA:P95043" FT /db_xref="InterPro:IPR000172" FT /db_xref="InterPro:IPR007867" FT /db_xref="InterPro:IPR012132" FT /db_xref="UniProtKB/TrEMBL:P95043" FT /protein_id="CAB06460.1" FT /translation="MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLAD FT PGLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAINGGYFCRG FT LPSDFDRASIPGWAWSDVLEHFRAIETDLDFETPVHGRSGPIPVRRTHEMTGITESFMA FT AAEDAGFAWIADLNDVGPEMPSGVGAVPLNIVNGVRTSSAVGYLMPALGRPNLTLLART FT RAVRLRFSATTAVGVDAIGPGGPVSLSADRIVLCAGAIQSAHLLMLSGVGEEEVLRSAG FT VKVLMALPVGMGCSDHPEWVMPTNWAVAVDRPVLEVLLSTHDGIEIRPYTGGFVAMTGD FT GTAGHRDWPHIGVALMQPRARGRITLVSSDPQIPVRIEHRYDSEPADVAALRQGSALAH FT ELCGAATRIGPAVWATSQHLCGSAPMGTDDDPRAVVDPRCRVRGIENLWVIDGSVLPSI FT TSRGPHATIVMLGHRAAEFVQ" FT CDS 114560..115171 FT /transl_table=11 FT /locus_tag="Rv0698" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0698, (MTCY210.15), len: 203 aa. Conserved FT hypothetical protein, highly similar to C-terminus of FT Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (188 aa), FASTA scores: E(): FT 2.1e-07, (54.8% identity in 73 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P95044" FT /protein_id="CAB06461.1" FT /translation="MGRRGNRRVHVDRVRLTGTERELRAENQSPPIFRPQNTLGDGANG FT LPLAVCTTTAHTCHTSHTHPSRWTPNPVPATKGVPAGLVQATFIIENLDPGNNDTPTPP FT TPKLRLARKPGHHRRSEYDADSVLRRKDTSRRCVQADDVRCVQLVQDPRRGRVELGGYR FT AELTVGRRAAVNCQRPQYGADGWPVRLGCGVGGAARGDQR" FT CDS 115356..115577 FT /transl_table=11 FT /locus_tag="Rv0699" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0699, (MTCY210.17), len: 73 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P95046" FT /protein_id="CAB06462.1" FT /translation="MGDRRVDLLAAKDSEIRRSMGAVPVGAGSSQVATSWASDRCIRCR FT AAILSADCANLARANSRGGLAVGGSAVS" FT CDS 116214..116519 FT /transl_table=11 FT /gene="rpsJ" FT /locus_tag="Rv0700" FT /standard_name="nusE" FT /product="30S RIBOSOMAL PROTEIN S10 RPSJ (TRANSCRIPTION FT ANTITERMINATION FACTOR NUSE)" FT /function="THIS PROTEIN IS INVOLVED IN THE BINDING OF tRNA FT TO THE RIBOSOMES, AND IN THE REGULATION OF rRNA FT BIOSYNTHESIS (BY MODULATING THE EFFICIENCY OF FT TRANSCRIPTIONAL TERMINATION). INTERACTS WITH NUSB|Rv2533c." FT /note="Rv0700, (MTCY210.19), len: 101 aa. rpsJ (alternate FT gene name: nusE), 30S ribosomal protein S10 (see Gopal et FT al., 2001), equivalent to RS10_MYCLE P307653 30S ribosomal FT protein S10 from Mycobacterium leprae (101 aa), FASTA FT scores: opt: 645, E(): 0, (97.0% identity in 101 aa FT overlap). Also highly similar to others e.g. FT CAB82069.1|AL161803 30S ribosomal protein S10 from FT Streptomyces coelicolor (102 aa); etc. Contains PS00361 FT Ribosomal protein S10 signature. BELONGS TO THE S10P FAMILY FT OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5X0" FT /db_xref="InterPro:IPR001848" FT /db_xref="InterPro:IPR005731" FT /db_xref="InterPro:IPR018268" FT /db_xref="UniProtKB/Swiss-Prot:P0A5X0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06463.1" FT /translation="MAGQKIRIRLKAYDHEAIDASARKIVETVVRTGASVVGPVPLPTE FT KNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKTVDALMRIDLPASVDVNIQ" FT misc_feature 116298..116345 FT /note="PS00361 Ribosomal protein S10 signature" FT CDS 116536..117189 FT /transl_table=11 FT /gene="rplC" FT /locus_tag="Rv0701" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L3 RPLC" FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL RNA FT AND MAY PARTICIPATE IN THE FORMATION OF THE FT PEPTIDYLTRANSFERASE CENTER OF THE RIBOSOME." FT /note="Rv0701, (MTCY210.20), len: 217 aa. Probable rplC, FT 50S ribosomal protein L3, equivalent to O06044|RL3_MYCBO FT 50S RIBOSOMAL PROTEIN L3 from Mycobacterium bovis BCG (217 FT aa); and P30762|RL3_MYCLE 50S RIBOSOMAL PROTEIN L3 from FT Mycobacterium leprae (217 aa). Also highly similar to FT others e.g. CAB82070.1|AL161803 50S ribosomal protein L3 FT from Streptomyces coelicolor (214 aa); P52860|RL3_THETH FT ribosomal protein l3 from Thermus aquaticus (206 aa), FASTA FT scores: opt: 717, E(): 0, (55.2% identity in 210 aa FT overlap); etc. Contains PS00474 Ribosomal protein L3 FT signature. BELONGS TO THE L3P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P60442" FT /db_xref="InterPro:IPR000597" FT /db_xref="InterPro:IPR009000" FT /db_xref="InterPro:IPR019926" FT /db_xref="InterPro:IPR019927" FT /db_xref="UniProtKB/Swiss-Prot:P60442" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06464.1" FT /translation="MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERD FT GYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAE FT IFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKG FT TRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK" FT misc_feature 116851..116922 FT /note="PS00474 Ribosomal protein L3 signature" FT CDS 117189..117860 FT /transl_table=11 FT /gene="rplD" FT /locus_tag="Rv0702" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L4 RPLD" FT /function="THIS PROTEIN BINDS DIRECTLY AND SPECIFICALLY TO FT 23S RRNA." FT /note="Rv0702, (MTCY210.21), len: 223 aa. Probable rplD, FT 50S ribosomal protein L4, equivalent to O06045|RL4_MYCBO FT 50S RIBOSOMAL PROTEIN L4 from Mycobacterium bovis BCG (223 FT aa); O06114|RL4_MYCSM 50S RIBOSOMAL PROTEIN L4 from FT Mycobacterium smegmatis (215 aa); and MLCB2492_3 50S FT ribosomal protein L4 from Mycobacterium leprae (230 aa). FT Also highly similar to others e.g. CAB82071.1|AL161803 50S FT ribosomal protein L4 from Streptomyces coelicolor (219 aa); FT P28601|RL4_BACST 50s ribosomal protein L4 from Bacillus FT stearothermophilus (207 aa), FASTA scores: opt: 522, E(): FT 3.5e-26, (42.4% identity in 198 aa overlap); etc. BELONGS FT TO THE L4P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P60729" FT /db_xref="InterPro:IPR002136" FT /db_xref="InterPro:IPR013005" FT /db_xref="InterPro:IPR015498" FT /db_xref="UniProtKB/Swiss-Prot:P60729" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06465.1" FT /translation="MAAQEQKTLKIDVKTPAGKVDGAIELPAELFDVPANIALMHQVVT FT AQRAAARQGTHSTKTRGEVSGGGRKPYRQKGTGRARQGSTRAPQFTGGGVVHGPKPRDY FT SQRTPKKMIAAALRGALSDRARNGRIHAITELVEGQNPSTKSARAFLASLTERKQVLVV FT IGRSDEAGAKSVRNLPGVHILAPDQLNTYDVLRADDVVFSVEALNAYIAANTTTSEEVS FT A" FT CDS 117860..118162 FT /transl_table=11 FT /gene="rplW" FT /locus_tag="Rv0703" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L23 RPLW" FT /function="BINDS TO A SPECIFIC REGION ON THE 23S RRNA." FT /note="Rv0703, (MTCY21.22), len: 100 aa. Probable rplW, 50S FT ribosomal protein L23, equivalent to O06046|RL23_MYCBO 50S FT RIBOSOMAL PROTEIN L23 from Mycobacterium bovis BCG (100 FT aa); and MLCB2492_4 50S RIBOSOMAL PROTEIN L23 from FT Mycobacterium leprae (100 aa). Also highly similar to FT others e.g. CAB82072.1|AL161803 50S ribosomal protein L23 FT from Streptomyces coelicolor (139 aa) (N-terminus longer); FT P04454|RL23_BACST 50s ribosomal protein L23 from Bacillus FT stearothermophilus (95 aa), FASTA scores: opt: 275, E(): FT 1.4e-13, (50.5% identity in 95 aa overlap); etc. Contains FT PS00050 Ribosomal protein L23 signature. BELONGS TO THE FT L23P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P95051" FT /db_xref="InterPro:IPR001014" FT /db_xref="InterPro:IPR012677" FT /db_xref="InterPro:IPR012678" FT /db_xref="InterPro:IPR013025" FT /db_xref="UniProtKB/Swiss-Prot:P95051" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06466.1" FT /translation="MATLADPRDIILAPVISEKSYGLLDDNVYTFLVRPDSNKTQIKIA FT VEKIFAVKVASVNTANRQGKRKRTRTGYGKRKSTKRAIVTLAPGSRPIDLFGAPA" FT misc_feature 118097..118144 FT /note="PS00050 Ribosomal protein L23 signature" FT repeat_region 118156..118204 FT /note="49 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 118255..119097 FT /transl_table=11 FT /gene="rplB" FT /locus_tag="Rv0704" FT /product="PROBABLE 50S ribosomal protein L2 RPLB" FT /function="THIS PROTEIN IS A PRIMARY 23S RRNA-BINDING FT PROTEIN. IT HAS PEPTIDYLTRANSFERASE ACTIVITY." FT /note="Rv0704, (MTCY210.23), len: 280 aa. Probable rplB, FT 50S ribosomal protein L2, equivalent to O06047|RL2_MYCBO FT 50S RIBOSOMAL PROTEIN L2 from Mycobacterium bovis BCG (280 FT aa); and MLCB2492_5M 50S RIBOSOMAL PROTEIN L2 from FT Mycobacterium leprae (280 aa). Also highly similar to FT others e.g. CAB82073.1|AL161803 50S ribosomal protein L2 FT from Streptomyces coelicolor (278 aa); P42919|RL2_BACSU 50s FT ribosomal protein l2 (bl2) from Bacillus subtilis (276 aa), FT FASTA scores: opt: 1179, E(): 0, (61.1% identity in 275 aa FT overlap); etc. Contains PS00467 Ribosomal protein L2 FT signature. BELONGS TO THE L2P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P95052" FT /db_xref="InterPro:IPR002171" FT /db_xref="InterPro:IPR005880" FT /db_xref="InterPro:IPR008991" FT /db_xref="InterPro:IPR012340" FT /db_xref="InterPro:IPR014722" FT /db_xref="InterPro:IPR016027" FT /db_xref="UniProtKB/Swiss-Prot:P95052" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06467.1" FT /translation="MAIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGRGGRNA FT HGRITTRHKGGGHKRAYRMIDFRRNDKDGVNAKVAHIEYDPNRTARIALLHYLDGEKRY FT IIAPNGLSQGDVVESGANADIKPGNNLPLRNIPAGTLIHAVELRPGGGAKLARSAGSSI FT QLLGKEASYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPSVR FT GVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRNANKSSNKFIVRRRRTGKKHSR" FT misc_feature 118909..118944 FT /note="PS00467 Ribosomal protein L2 signature" FT CDS 119138..119419 FT /transl_table=11 FT /gene="rpsS" FT /locus_tag="Rv0705" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S19 RPSS" FT /function="PROTEIN S19 FORMS A COMPLEX WITH S13 THAT BINDS FT STRONGLY TO THE 16S RIBOSOMAL RNA." FT /note="Rv0705, (MTCY210.24), len: 93 aa. Probable rpsS, 30S FT ribosomal protein S19, equivalent to S36895 ribosomal FT protein S19 from Mycobacterium bovis (93 aa), FASTA scores: FT opt: 623, E(): 0, (98.9% identity in 93 aa overlap); and FT NP_302261.1|NC_002677 30S ribosomal protein S19 from FT Mycobacterium leprae (93 aa). Also highly similar to others FT e.g. CAB82074.1|AL161803 30S ribosomal protein S19 from FT Streptomyces coelicolor (93 aa); etc. Contains PS00323 FT Ribosomal protein S19 signature. BELONGS TO THE S19P FAMILY FT OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5X4" FT /db_xref="InterPro:IPR002222" FT /db_xref="InterPro:IPR005732" FT /db_xref="UniProtKB/Swiss-Prot:P0A5X4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06468.1" FT /translation="MPRSLKKGPFVDEHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFI FT GHTFAVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHIKDDRKSKRR" FT misc_feature 119294..119368 FT /note="PS00323 Ribosomal protein S19 signature" FT CDS 119416..120009 FT /transl_table=11 FT /gene="rplV" FT /locus_tag="Rv0706" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L22 RPLV" FT /function="THIS PROTEIN BINDS SPECIFICALLY TO 23S RRNA; ITS FT BINDING IS STIMULATED BY OTHER RIBOSOMAL PROTEINS, E.G., FT L4, L17, AND L20. IT IS IMPORTANT DURING THE EARLY STAGES FT OF 50S RECONSTITUTION." FT /note="Rv0706, (MTCY210.25), len: 197 aa. Probable rplV, FT 50S ribosomal protein L22, equivalent to O06115|RL22_MYCSM FT 50S RIBOSOMAL PROTEIN L22 from Mycobacterium smegmatis (153 FT aa); MBS10OPER_7 50S RIBOSOMAL PROTEIN L22 from FT Mycobacterium bovis BCG; and MLCB2492_7 50S ribosomal FT protein L22 from Mycobacterium leprae (175 aa). Also highly FT similar to others e.g. CAB82075.1|AL161803 50S ribosomal FT protein L22 from Streptomyces coelicolor (125 aa); FT P42060|RL22_BACSU 50s ribosomal protein L22 from Bacillus FT subtilis (113 aa), FASTA scores: opt: 368, E(): 2.4e-13, FT (52.8% identity in 108 aa overlap); etc. Contains PS00464 FT Ribosomal protein L22 signature, and contains repetitive FT sequence at C-terminus. BELONGS TO THE L22P FAMILY OF FT RIBOSOMAL PROTEINS." FT /db_xref="GOA:P61181" FT /db_xref="InterPro:IPR001063" FT /db_xref="InterPro:IPR005727" FT /db_xref="InterPro:IPR018260" FT /db_xref="UniProtKB/Swiss-Prot:P61181" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06469.1" FT /translation="MTAATKATEYPSAVAKARFVRVSPRKARRVIDLVRGRSVSDALDI FT LRWAPQAASGPVAKVIASAAANAQNNGGLDPATLVVATVYADQGPTAKRIRPRAQGRAF FT RIRRRTSHITVVVESRPAKDQRSAKSSRARRTEASKAASKVGATAPAKKAAAKAPAKKA FT PASSGVKKTPAKKAPAKKAPAKASETSAAKGGSD" FT misc_feature 119692..119766 FT /note="PS00464 Ribosomal protein L22 signature" FT CDS 120009..120833 FT /transl_table=11 FT /gene="rpsC" FT /locus_tag="Rv0707" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S3 RPSC" FT /function="THIS PROTEIN IS INVOLVED IN THE BINDING OF FT INITIATOR MET-TRNA." FT /note="Rv0707, (MTCY210.26), len: 274 aa. Probable rpsC, FT 30S ribosomal protein S3, equivalent to FT O06048|RS3_MYCBO|MBS10OPER_8 30S RIBOSOMAL PROTEIN S3 from FT Mycobacterium bovis BCG (274 aa); and MLCB2492_8 30S FT RIBOSOMAL PROTEIN S3 from Mycobacterium leprae (281 aa). FT Also highly similar to others e.g. CAB82076.1|AL161803 30S FT ribosomal protein S3 from Streptomyces coelicolor (277 aa); FT P21465|RS3_BACSU 30s ribosomal protein s3 (bs3) (bs2) from FT Bacillus subtilis (217 aa), FASTA scores: opt: 794, E(): 0, FT (52.8% identity in 212 aa overlap); etc. BELONGS TO THE S3P FT FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5X6" FT /db_xref="InterPro:IPR001351" FT /db_xref="InterPro:IPR004044" FT /db_xref="InterPro:IPR004087" FT /db_xref="InterPro:IPR005704" FT /db_xref="InterPro:IPR008282" FT /db_xref="InterPro:IPR009019" FT /db_xref="InterPro:IPR015946" FT /db_xref="InterPro:IPR018280" FT /db_xref="UniProtKB/Swiss-Prot:P0A5X6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06470.1" FT /translation="MGQKINPHGFRLGITTDWKSRWYADKQYAEYVKEDVAIRRLLSSG FT LERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQLNILE FT VKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGAEMS FT RSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELAAAAPAGA FT DRPRRERPSGTRPRRSGASGTTATGTDAGRAAGGEEAAPDAAAPVEAQSTES" FT CDS 120837..121253 FT /transl_table=11 FT /gene="rplP" FT /locus_tag="Rv0708" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L16 RPLP" FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL RNA FT AND IS LOCATED AT THE A SITE OF THE PEPTIDYLTRANSFERASE FT CENTER." FT /note="Rv0708, (MTCY210.27), len: 138 aa. Probable rplP, FT 50S ribosomal protein L16, equivalent to FT O06049|RL16_MYCBO|MBS10OPER_9 50S RIBOSOMAL PROTEIN L16 FT from Mycobacterium bovis BCG (138 aa); and MLCB2492_9 50S FT RIBOSOMAL PROTEIN L16 from Mycobacterium leprae (138 aa). FT Also highly similar to others e.g. CAB82077.1|AL161803 50S FT ribosomal protein L16 from Streptomyces coelicolor (139 FT aa); P14577|RL16_BACSU 50s ribosomal protein l16 from FT Bacillus subtilis (144 aa), FASTA scores: opt: 600, E(): 0, FT (63.2% identity in 136 aa overlap); etc. Contains PS00701 FT Ribosomal protein L16 signature 2. BELONGS TO THE L16P FT FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P95056" FT /db_xref="InterPro:IPR000114" FT /db_xref="InterPro:IPR016180" FT /db_xref="InterPro:IPR020798" FT /db_xref="UniProtKB/Swiss-Prot:P95056" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06432.1" FT /translation="MLIPRKVKHRKQHHPRQRGIASGGTTVNFGDYGIQALEHAYVTNR FT QIESARIAINRHIKRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRVLF FT ELSYPNEGVARAALTRAIHKLPIKARIITREEQF" FT misc_feature 121080..121115 FT /note="PS00701 Ribosomal protein L16 signature 2" FT CDS 121253..121486 FT /transl_table=11 FT /gene="rpmC" FT /locus_tag="Rv0709" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L29 RPMC" FT /function="INVOLVED IN TRANSLATION MECHANISMS." FT /note="Rv0709, (MTCY210.28), len: 77 aa. Probable rpmC, 50S FT ribosomal protein L29, equivalent to FT O06050|RL29_MYCBO|MBS10OPER_10 50S RIBOSOMAL PROTEIN L29 FT from Mycobacterium bovis BCG (75 aa); and FT O32989|RL29_MYCLE|MLCB2492_10 50S RIBOSOMAL PROTEIN L29 FT from Mycobacterium leprae (80 aa). Also highly similar to FT others e.g. Q9L0D2|RL29_STRCO 50S RIBOSOMAL PROTEIN L29 FT from Streptomyces coelicolor (74 aa); P12873|RL29_BACSU 50s FT ribosomal protein l29 from Bacillus subtilis (66 aa), FASTA FT scores: opt: 225, E(): 8.3e-11, (58.6% identity in 58 aa FT overlap); etc. BELONGS TO THE L29P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P95057" FT /db_xref="InterPro:IPR001854" FT /db_xref="InterPro:IPR018254" FT /db_xref="UniProtKB/Swiss-Prot:P95057" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06433.1" FT /translation="MAVGVSPGELRELTDEELAERLRESKEELFNLRFQMATGQLNNNR FT RLRTVRQEIARIYTVLRERELGLATGPDGKES" FT CDS 121483..121893 FT /transl_table=11 FT /gene="rpsQ" FT /locus_tag="Rv0710" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S17 RPSQ" FT /function="PROTEIN S17 BINDS SPECIFICALLY TO THE 5' END OF FT 16S RIBOSOMAL RNA." FT /note="Rv0710, (MTCY210.29), len: 136 aa. Probable rpsQ, FT 30S ribosomal protein S17, equivalent to O06051|RS17_MYCBO FT 30S|MBS10OPER_11 30S RIBOSOMAL PROTEIN S17 from FT Mycobacterium bovis BCG (136 aa); and MLCB2492_11 30S FT RIBOSOMAL PROTEIN S17 from Mycobacterium leprae (126 aa). FT Also highly similar to others e.g. CAB82079.1|AL161803 30S FT ribosomal protein S17 from Streptomyces coelicolor (95 aa); FT P12874|RS17_BACSU 30s ribosomal protein s17 (bs 16) from FT Bacillus subtilis (86 aa), FASTA scores: opt: 305, E(): FT 1.6e-11, (60.5% identity in 81 aa overlap); etc. Contains FT PS00056 Ribosomal protein S17 signature." FT /db_xref="GOA:P95058" FT /db_xref="InterPro:IPR000266" FT /db_xref="InterPro:IPR012340" FT /db_xref="InterPro:IPR016027" FT /db_xref="InterPro:IPR019979" FT /db_xref="InterPro:IPR019984" FT /db_xref="UniProtKB/Swiss-Prot:P95058" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06434.1" FT /translation="MMAEAKTGAKAAPRVAKAAKAAPKKAAPNDAEAIGAANAANVKGP FT KHTPRTPKPRGRRKTRIGYVVSDKMQKTIVVELEDRMRHPLYGKIIRTTKKVKAHDEDS FT VAGIGDRVSLMETRPLSATKRWRLVEILEKAK" FT misc_feature 121807..121845 FT /note="PS00056 Ribosomal protein S17 signature" FT CDS 122062..124425 FT /transl_table=11 FT /gene="atsA" FT /locus_tag="Rv0711" FT /product="POSSIBLE ARYLSULFATASE ATSA (ARYL-SULFATE FT SULPHOHYDROLASE) (ARYLSULPHATASE)" FT /function="THOUGHT TO PLAY AN IMPORTANT ROLE IN THE FT MINERALIZATION OF SULFATES [CATALYTIC ACTIVITY: A phenol FT sulfate + H2O = a phenol + sulfate]." FT /EC_number="3.1.6.1" FT /note="Rv0711, (MTCY210.30), len: 787 aa. Possible atsA, FT arylsulfatase (EC 3.1.6.1), similar to others e.g. FT P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa FT (532 aa), FASTA scores: opt: 439, E(): 2.9e-21, (30.8% FT identity in 552 aa overlap); etc. Also similar to other FT hypothetical arylsulfatases from Mycobacterium tuberculosis FT e.g. Rv3299c, Rv0663, etc. Contains PS00523 Sulfatases FT signature 1, and PS00149 Sulfatases signature 2. BELONGS TO FT THE SULFATASE FAMILY." FT /db_xref="GOA:P95059" FT /db_xref="HSSP:1E33" FT /db_xref="InterPro:IPR000917" FT /db_xref="InterPro:IPR017849" FT /db_xref="InterPro:IPR017850" FT /db_xref="UniProtKB/TrEMBL:P95059" FT /protein_id="CAB06435.1" FT /translation="MAPEATEAFNGTIELDIRDSEPDWGPYAAPVAPEHSPNILYLVWD FT DVGIATWDCFGGLVEMPAMTRVAERGVRLSQFHTTALCSPTRASLLTGRNATTVGMATI FT EEFTDGFPNCNGRIPADTALLPEVLAEHGYNTYCVGKWHLTPLEESNMASTKRHWPTSR FT GFERFYGFLGGETDQWYPDLVYDNHPVSPPGTPEGGYHLSKDIADKTIEFIRDAKVIAP FT DKPWFSYVCPGAGHAPHHVFKEWADRYAGRFDMGYERYREIVLERQKALGIVPPDTELS FT PINPYLDVPGPNGETWPLQDTVRPWDSLSDEEKKLFCRMAEVFAGFLSYTDAQIGRILD FT YLEESGQLDNTIIVVISDNGASGEGGPNGSVNEGKFFNGYIDTVAESMKLFDHLGGPQT FT YNHYPIGWAMAFNTPYKLFKRYASHEGGIADPAIISWPNGIAAHGEIRDNYVNVSDITP FT TVYDLLGMTPPGTVKGIPQKPMDGVSFIAALADPAADTGKTTQFYTMLGTRGIWHEGWF FT ANTIHAATPAGWSNFNADRWELFHIAADRSQCHDLAAEHPDKLEELKALWFSEAAKYNG FT LPLADLNLLETMTRSRPYLVSERASYVYYPDCADVGIGAAVEIRGRSFAVLADVTIDTT FT GAEGVLFKHGGAHGGHVLFVRDGRLHYVYNFLGERQQLVSSSGPVPSGRHLLGVRYLRT FT GTVPNSHTPVGDLELFFDENLVGALTNVLTHPGTFGLAGAAISVGRNGGSAVSSHYEAP FT FAFTGGTITQVTVDVSGRPFEDVESDLALAFSRD" FT misc_feature 122179..122223 FT /note="PS00678 Beta-transducin family Trp-Asp repeats FT signature" FT misc_feature 122302..122340 FT /note="PS00523 Sulfatases signature 1" FT misc_feature 122458..122487 FT /note="PS00149 Sulfatases signature 2" FT CDS 124473..125372 FT /transl_table=11 FT /locus_tag="Rv0712" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0712, (MTCY210.31), len: 299 aa. Conserved FT hypothetical protein, similar to others e.g. FT NP_106128.1|NC_002678 hypothetical protein from FT Mesorhizobium loti (372 aa); D90901_33|P72841 HYPOTHETICAL FT 48.1 kDa PROTEIN from Synechocystis sp (410 aa), FASTA FT scores: E(): 1.1e-07, (28.8% identity in 299 aa overlap); FT etc. Slight similarity to carboxykinases. Similar to FT C-terminal part of Rv3703c CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (425 aa)." FT /db_xref="InterPro:IPR005532" FT /db_xref="UniProtKB/TrEMBL:P95060" FT /protein_id="CAB06436.1" FT /translation="MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTNA FT QFAEFVSATGYVTVAEQPLDPGLYPGVDAADLCPGAMVFCPTAGPVDLRDWRQWWDWVP FT GACWRHPFGRDSDIADRAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTTATY FT AWGDQEKPGGMLMANTWQGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVWEWTT FT TEFYPHHRIDPPSTACCAPVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAARSPQSQ FT DTATTHIGFRCVADPVSG" FT CDS 125673..126614 FT /transl_table=11 FT /locus_tag="Rv0713" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0713, (MTCY210.32), len: 313 aa. Probable FT conserved transmembrane protein, similar to FT Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis FT (284 aa), FASTA scores: opt: 557, E(): 2.1e-29, (35.8% FT identity in 282 aa overlap); MLCB2492_12|O32991 FT HYPOTHETICAL 10.7 kDa PROTEIN from Mycobacterium leprae (95 FT aa)." FT /db_xref="GOA:P95061" FT /db_xref="UniProtKB/TrEMBL:P95061" FT /protein_id="CAB06437.1" FT /translation="MAGSDPPTGGPASQAGSDAGASPEHKHMSRRKHLVLDVCIILGVL FT IAYVFSLLGYDWLAHTPGPLPQPDVGTTDDTVVLIRFEELHTVANRLDVKVLVLPDDSM FT IDHRLQVLTTDTSVRLYPENELGDLQYPVGKLPAQVATTIEAHGNPGAWPFDTYTTDTV FT QADVLVGAGDNRQYVPARVEVTGSLEGWDISAVRVGESSQTSDRPDNVIITLKRAKGPL FT VFDLGICLVLITLPTLALFVAIQMITGRRKFQPPFGTWYAAMLFAVVPLRTILPGSPPA FT GAWIDRAVVIWVLIALAAAMVVYIVAWYRESD" FT CDS 127100..127468 FT /transl_table=11 FT /gene="rplN" FT /locus_tag="Rv0714" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L14 RPLN" FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA." FT /note="Rv0714, (MTCY210.33), len: 122 aa. Probable rplN, FT 50S ribosomal protein L14, equivalent to FT O32993|MLCB2492_14|ML1849|RL14_MYCLE 50S RIBOSOMAL PROTEIN FT L14 from Mycobacterium leprae (122 aa). Also highly similar FT to others e.g. CAB82080.1|AL161803 50S ribosomal protein FT L14 from Streptomyces coelicolor (122 aa); FT P33100|RL14_MICLU 50s ribosomal protein L14 from FT Micrococcus luteus (122 aa), FASTA scores: opt: 674, E(): FT 0, (85.2% identity in 122 aa overlap); etc. Contains FT PS00049 Ribosomal protein L14 signature. BELONGS TO THE FT L14P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66069" FT /db_xref="InterPro:IPR000218" FT /db_xref="InterPro:IPR005745" FT /db_xref="InterPro:IPR019972" FT /db_xref="UniProtKB/Swiss-Prot:P66069" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06438.1" FT /translation="MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKD FT AIPGGNVKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGTRIFGPVGR FT ELREKRFMKIISLAPEVL" FT misc_feature 127277..127357 FT /note="PS00049 Ribosomal protein L14 signature" FT CDS 127469..127786 FT /transl_table=11 FT /gene="rplX" FT /locus_tag="Rv0715" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L24 RPLX" FT /function="THIS PROTEIN IS FOUND IN THE RIBONUCLEOPROTEIN FT CORE AND IS INVOLVED IN THE EARLY ASSEMBLY OF THE 50S FT SUBUNIT. IT IS NOT INVOLVED IN THE FUNCTIONS OF THE MATURE FT 50S SUBUNIT." FT /note="Rv0715, (MTCY210.34), len: 105 aa. Probable rplX, FT 50S ribosomal protein L24, equivalent to O32994|MLCB2492_15 FT 50S RIBOSOMAL PROTEIN L24 from Mycobacterium leprae (105 FT aa). Also highly similar to others e.g. CAB82081.1|AL161803 FT 50S ribosomal protein L24 from Streptomyces coelicolor (107 FT aa); P12876|RL24_BACSU 50s ribosomal protein L24 (bl23) FT from Bacillus subtilis (103 aa), FASTA scores: opt: 363, FT E(): 1.8e-18, (56.7% identity in 104 aa overlap); etc. FT Contains PS01108 Ribosomal protein L24 signature. BELONGS FT TO THE L24P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P60627" FT /db_xref="InterPro:IPR003256" FT /db_xref="InterPro:IPR005824" FT /db_xref="InterPro:IPR005825" FT /db_xref="InterPro:IPR008991" FT /db_xref="InterPro:IPR014723" FT /db_xref="UniProtKB/Swiss-Prot:P60627" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06439.1" FT /translation="MKVHKGDTVLVISGKDKGAKGKVLQAYPDRNRVLVEGVNRIKKHT FT AISTTQRGARSGGIVTQEAPIHVSNVMVVDSDGKPTRIGYRVDEETGKRVRISKRNGKD FT I" FT misc_feature 127493..127537 FT /note="PS01108 Ribosomal protein L24 signature" FT CDS 127786..128349 FT /transl_table=11 FT /gene="rplE" FT /locus_tag="Rv0716" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L5 RPLE" FT /function="THIS IS ONE OF 3 PROTEINS THAT MEDIATE THE FT ATTACHMENT OF THE 5S RNA INTO THE LARGE RIBOSOMAL SUBUNIT." FT /note="Rv0716, (MTCY210.35), len: 187 aa. Probable rplE, FT 50S ribosomal protein L5, equivalent to MLCB2492_16 50S FT RIBOSOMAL PROTEIN L5 from Mycobacterium leprae (187 aa). FT Also highly similar to others e.g. CAB82082.1|AL161803 50S FT ribosomal protein L5 from Streptomyces coelicolor (185 aa); FT P33098|RL5_MICLU 50S RIBOSOMAL PROTEIN L5 from Micrococcus FT luteus (191 aa), FASTA scores: opt: 930, E(): 0, (73.8% FT identity in 183 aa overlap); etc. BELONGS TO THE L5P FAMILY FT OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P62403" FT /db_xref="InterPro:IPR002132" FT /db_xref="UniProtKB/Swiss-Prot:P62403" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06440.1" FT /translation="MTTAQKVQPRLKERYRSEIRDALRKQFGYGNVMQIPTVTKVVVNM FT GVGEAARDAKLINGAVNDLALITGQKPEVRRARKSIAQFKLREGMPVGVRVTLRGDRMW FT EFLDRLTSIALPRIRDFRGLSPKQFDGVGNYTFGLAEQAVFHEVDVDKIDRVRGMDINV FT VTSAATDDEGRALLRALGFPFKEN" FT CDS 128354..128539 FT /transl_table=11 FT /gene="rpsN1" FT /locus_tag="Rv0717" FT /standard_name="rpsN" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S14 RPSN1" FT /function="KNOWN TO BE REQUIRED FOR THE ASSEMBLY OF 30S FT PARTICLES AND MAY ALSO BE RESPONSIBLE FOR DETERMINING THE FT CONFORMATION OF THE 16S RRNA AT THE A SITE." FT /note="Rv0717, (MTCY210.36), len: 61 aa. Probable rpsN1, FT 30S ribosomal protein S14, equivalent to MLCB2492_17|O32996 FT RIBOSOMAL PROTEIN S14 from Mycobacterium leprae (61 aa). FT Also highly similar to others e.g. CAB82083.1|AL161803 30S FT ribosomal protein S14 from Streptomyces coelicolor (61 aa); FT P24320|RS14_THETH 30s ribosomal protein S14 from Thermus FT aquaticus (subsp. thermophilus) (60 aa), FASTA scores: opt: FT 316, E(): 2e-19,(70.0% identity in 60 aa overlap); etc. FT Contains PS00527 Ribosomal protein S14 signature. BELONGS FT TO THE S14P FAMILY OF RIBOSOMAL PROTEINS. Note that FT previously known as rpsN." FT /db_xref="GOA:P0A5X2" FT /db_xref="InterPro:IPR001209" FT /db_xref="InterPro:IPR018271" FT /db_xref="UniProtKB/Swiss-Prot:P0A5X2" FT /protein_id="CAE55312.1" FT /translation="MAKKALVNKAAGKPRFAVRAYTRCSKCGRPRAVYRKFGLCRICLR FT EMAHAGELPGVQKSSW" FT misc_feature 128420..128488 FT /note="PS00527 Ribosomal protein S14 signature" FT repeat_region 128562..128648 FT /note="87 bp Mycobacterial Interspersed Repetitive Unit, FT Class III" FT repeat_region 128649..128702 FT /note="54 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 128703..129101 FT /transl_table=11 FT /gene="rpsH" FT /locus_tag="Rv0718" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S8 RPSH" FT /function="BINDS DIRECTLY TO THE CENTRAL DOMAIN OF 16S FT RIBOSOMAL RNA." FT /note="Rv0718, (MTCY210.37), len: 132 aa. Probable rpsH, FT 30S ribosomal protein S8, equivalent to O32997|MLCB2492_18 FT 30S RIBOSOMAL PROTEIN S8 from Mycobacterium leprae (132 FT aa). Also highly similar to others e.g. CAB82084.1|AL161803 FT 30S ribosomal protein S8 from Streptomyces coelicolor (132 FT aa); P33106|RS8_MICLU 30s ribosomal protein S8 from FT Micrococcus luteus (132 aa), FASTA scores: opt: 669, E(): FT 0, (77.3% identity in 132 aa overlap); etc. Contains FT PS00053 Ribosomal protein S8 signature. BELONGS TO THE S8P FT FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66625" FT /db_xref="InterPro:IPR000630" FT /db_xref="UniProtKB/Swiss-Prot:P66625" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06442.1" FT /translation="MTMTDPIADFLTRLRNANSAYHDEVSLPHSKLKANIAQILKNEGY FT ISDFRTEDARVGKSLVIQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVA FT IISTSSGLLTDRQAARQGVGGEVLAYVW" FT misc_feature 129006..129059 FT /note="PS00053 Ribosomal protein S8 signature" FT CDS 129125..129664 FT /transl_table=11 FT /gene="rplF" FT /locus_tag="Rv0719" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L6 RPLF" FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL RNA FT AND IS LOCATED AT THE AMINOACYL-TRNA BINDING SITE OF THE FT PEPTIDYLTRANSFERASE CENTER." FT /note="Rv0719, (MTCY210.38), len: 179 aa. Probable rplF, FT 50S ribosomal protein L6, equivalent to O32998|MLCB2492_19 FT 50S RIBOSOMAL PROTEIN L6 from Mycobacterium leprae (179 FT aa). Also highly similar to others e.g. FT P46786|RL6_STRCO|CAB82085.1|AL161803|SCD31.42 50S ribosomal FT protein L6 from Streptomyces coelicolor (179 aa), FASTA FT scores: opt: 872, E(): 0, (70.4% identity in 179 aa FT overlap); etc. Contains PS00525 Ribosomal protein L6 FT signature 1. BELONGS TO THE L6P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P66311" FT /db_xref="InterPro:IPR000702" FT /db_xref="InterPro:IPR002358" FT /db_xref="InterPro:IPR019906" FT /db_xref="InterPro:IPR020040" FT /db_xref="UniProtKB/Swiss-Prot:P66311" FT /protein_id="CAB06443.1" FT /translation="MSRIGKQPIPVPAGVDVTIEGQSISVKGPKGTLGLTVAEPIKVAR FT NDDGAIVVTRPDDERRNRSLHGLSRTLVSNLVTGVTQGYTTKMEIFGVGYRVQLKGSNL FT EFALGYSHPVVIEAPEGITFAVQAPTKFTVSGIDKQKVGQIAANIRRLRRPDPYKGKGV FT RYEGEQIRRKVGKTGK" FT misc_feature 129587..129613 FT /note="PS00525 Ribosomal protein L6 signature 1" FT CDS 129667..130035 FT /transl_table=11 FT /gene="rplR" FT /locus_tag="Rv0720" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L18 RPLR" FT /function="THIS IS ONE OF 3 PROTEINS THAT MEDIATE THE FT ATTACHMENT OF THE 5S RNA INTO THE LARGE RIBOSOMAL SUBUNIT." FT /note="Rv0720, (MTCY210.39), len: 122 aa. Probable rplR, FT 50S ribosomal protein L18, equivalent to FT O32999|MLCB2492_20|RL18_MYCLE 50S RIBOSOMAL PROTEIN L18 FT from Mycobacterium leprae (122 aa). Also highly similar to FT others e.g. CAB82086.1|AL161803 50S ribosomal protein L18 FT from Streptomyces coelicolor (127 aa); P33102|RL18_MICLU FT 50s ribosomal protein L18 from Micrococcus luteus (119 aa), FT FASTA scores: opt: 447, E(): 8.7e-24, (60.4% identity in FT 111 aa overlap); etc. BELONGS TO THE L18P FAMILY OF FT RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66076" FT /db_xref="InterPro:IPR004389" FT /db_xref="InterPro:IPR005484" FT /db_xref="UniProtKB/Swiss-Prot:P66076" FT /protein_id="CAB06444.1" FT /translation="MAQSVSATRRISRLRRHTRLRKKLSGTAERPRLVVHRSARHIHVQ FT LVNDLNGTTVAAASSIEADVRGVPGDKKARSVRVGQLIAERAKAAGIDTVVFDRGGYTY FT GGRIAALADAARENGLSF" FT CDS 130055..130717 FT /transl_table=11 FT /gene="rpsE" FT /locus_tag="Rv0721" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S5 RPSE" FT /function="PROTEIN S5 IS IMPORTANT IN THE ASSEMBLY AND FT FUNCTION OF THE 30S RIBOSOMAL SUBUNIT." FT /note="Rv0721, (MTCY210.40), len: 220 aa. Probable rpsE, FT 30S ribosomal protein S5, equivalent to MLCB2492_21 FT RIBOSOMAL PROTEIN S5 from Mycobacterium leprae (217 aa). FT Also highly similar to others e.g. P46790|RS5_STRCO 30s FT ribosomal protein S5 from Streptomyces coelicolor (167 aa), FT FASTA scores: opt: 889, E(): 0, (82.1% identity in 162 aa FT overlap); etc. Note N-terminus is extented compared to FT other rpsE genes. Contains PS00585 Ribosomal protein S5 FT signature, PTS HPr component phosphorylation sites FT signature. BELONGS TO THE S5P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P66574" FT /db_xref="InterPro:IPR000851" FT /db_xref="InterPro:IPR005324" FT /db_xref="InterPro:IPR005712" FT /db_xref="InterPro:IPR013810" FT /db_xref="InterPro:IPR014720" FT /db_xref="InterPro:IPR018192" FT /db_xref="InterPro:IPR020568" FT /db_xref="UniProtKB/Swiss-Prot:P66574" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06445.1" FT /translation="MAEQPAGQAGTTDNRDARGDREGRRRDSGRGSRERDGEKSNYLER FT VVAINRVSKVVKGGRRFSFTALVIVGDGNGMVGVGYGKAKEVPAAIAKGVEEARKSFFR FT VPLIGGTITHPVQGEAAAGVVLLRPASPGTGVIAGGAARAVLECAGVHDILAKSLGSDN FT AINVVHATVAALKLLQRPEEVAARRGLPIEDVAPAGMLKARRKSEALAASVLPDRTI" FT misc_feature 130229..130327 FT /note="PS00585 Ribosomal protein S5 signature" FT misc_feature 130334..130381 FT /note="PS00589 PTS HPR component serine phosphorylation FT site signature" FT CDS 130720..130917 FT /transl_table=11 FT /gene="rpmD" FT /locus_tag="Rv0722" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L30 RPMD" FT /function="INVOLVED ION TRANSLATION MECHANISMS." FT /note="Rv0722, (MTCY210.41), len: 65 aa. Probable rpmD, 50S FT ribosomal protein L30, equivalent to O33001 RIBOSOMAL FT PROTEIN L30 from Mycobacterium leprae (71 aa). Also highly FT similar to others e.g. P46789|RL30_STRCO 50S RIBOSOMAL FT PROTEIN L30 from Streptomyces coelicolor (60 aa); FT P02430|RL30_ECOLI 50S ribosomal protein L30 from FT Escherichia coli (58 aa), FASTA scores: opt: 168, E(): FT 1.5e-13, (53.7% identity in 54 aa overlap); etc. BELONGS TO FT THE L30P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66181" FT /db_xref="InterPro:IPR000517" FT /db_xref="InterPro:IPR005996" FT /db_xref="InterPro:IPR016082" FT /db_xref="InterPro:IPR018038" FT /db_xref="UniProtKB/Swiss-Prot:P66181" FT /protein_id="CAB06446.1" FT /translation="MSQLKITQVRSTIGARWKQRESLRTLGLRRIRHSVIREDNAATRG FT LIAVVRHLVEVEPAQTGGKT" FT CDS 130917..131357 FT /transl_table=11 FT /gene="rplO" FT /locus_tag="Rv0723" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L15 RPLO" FT /function="THIS PROTEIN BINDS DIRECTLY TO 23S RIBOSOMAL FT RNA." FT /note="Rv0723, (MTCY210.42), len: 146 aa. Probable rplO, FT 50S ribosomal protein L15, equivalent to MLCB2492_23|O33002 FT 50S RIBOSOMAL PROTEIN L15 from Mycobacterium leprae (146 FT aa). Also highly similar to others e.g. FT P46787|RL15_STRCO|SCD31.46 50S RIBOSOMAL PROTEIN L15 from FT Streptomyces coelicolor (151 aa); P19946|RL15_BACSU 50s FT ribosomal protein L15 from Bacillus subtilis (146 aa), FT FASTA scores: opt: 419, E(): 6.5e-20, (51.0% identity in FT 145 aa overlap); etc. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop), and PS00475 Ribosomal protein L15 FT signature. BELONGS TO THE L15P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P95071" FT /db_xref="InterPro:IPR001196" FT /db_xref="InterPro:IPR005749" FT /db_xref="UniProtKB/Swiss-Prot:P95071" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06447.1" FT /translation="MTLKLHDLRPARGSKIARTRVGRGDGSKGKTAGRGTKGTRARKQV FT PVTFEGGQMPIHMRLPKLKGFRNRFRTEYEIVNVGDINRLFPQGGAVGVDDLVAKGAVR FT KNALVKVLGDGKLTAKVDVSAHKFSGSARAKITAAGGSATEL" FT misc_feature 130986..131009 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 131244..131336 FT /note="PS00475 Ribosomal protein L15 signature" FT CDS 131390..133261 FT /transl_table=11 FT /gene="sppA" FT /locus_tag="Rv0724" FT /product="POSSIBLE PROTEASE IV SPPA (ENDOPEPTIDASE IV) FT (SIGNAL PEPTIDE PEPTIDASE)" FT /function="INVOLVED IN DIGESTION OF THE CLEAVED SIGNAL FT PEPTIDES. THIS ACTIVITY IS NECESSARY TO MAINTAIN PROPER FT SECRETION OF MATURE PROTEINS ACROSS THE MEMBRANE." FT /EC_number="3.4.21.-" FT /note="Rv0724, (MTCY210.43), len: 623 aa. Possible sppA, FT protease IV (endopeptidase IV) (EC 3.4.21.-), equivalent FT (but longer 23 aa) to MLCB2492_24|O33003 ENDOPEPTIDASE IV FT from Mycobacterium leprae (602 aa). Also similar to others FT e.g. NP_419743.1|NC_002696 signal peptide peptidase SppA FT from Caulobacter crescentus (594 aa); FT P08395|SPPA_ECOLI|B1766 protease IV (endopeptidase) from FT Escherichia coli strain K-12 (618 aa), FASTA scores: opt: FT 582, E(): 8.9e-27, (34.1% identity in 525 aa overlap); etc. FT BELONGS TO PEPTIDASE FAMILY S49." FT /db_xref="GOA:P95072" FT /db_xref="InterPro:IPR002142" FT /db_xref="InterPro:IPR004634" FT /db_xref="InterPro:IPR004635" FT /db_xref="UniProtKB/TrEMBL:P95072" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06448.1" FT /translation="MPIFGGFCVCSRALGGRWVRWVNMVAFLPSIPVVEDLRALVGRVD FT TARHHGVPNGCVLEFNLRSVPPETTGFDPLTVLTGGGRPMALRDAVAAIHRAAEDPRVA FT GLIARVQLPPSPAGAVQELREAIAAFSAVKPSLAWAETYPGTLSYYLASAFGEVWMQPS FT GSVGLVGFATNATFLRDALHKAGIEAQFVARGEYKSAANLFTEDGFTDAHREAVTRMLD FT SLQDQVWQAVAKSRNIGVDALDELADRAPLLRDDAVTCGLIDRIGFRDQAYARMAELVG FT VEKGSPESSGSQTSPDEKPPRMYLARYASSARPRLTPPVPSIPGRRSKPTIAVVTLEGP FT IVNGRGGPQFLPLGPSSAGGDTIAAALREVAADDSVSAIVLRVDSPGGSVTASETIWRE FT VARARDRGKPVVASMGAVAASGGYYVSMGADAIVANPGTITGSIGVITGKLVVRDLKDR FT LGVGSDAVRTNANADAWSIDAPFTPDQQAHREAEADLFYSDFVERVAEGRKMTTDAVDV FT VARGRVWTGADALDRGLVDELGGLRTAVRRAKVLAGLDEDTEVRIVSYPGSSLWDMVRP FT RPSSRPAAASLPDAMGALLARSIVGIVEQVEQTLSGASVLWLGESRL" FT CDS complement(133258..>133593) FT /transl_table=11 FT /locus_tag="Rv0724A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0724A, len: 111 aa. Similarity suggests that this FT CDS should be continuation of Rv0725c but we can find no FT frame-shift to account for this. Possible extended protein FT is very similar to other hypothetical Mycobacterium FT tuberculosis proteins e.g. Rv1729c|Z81360_12 (312 aa), FT FASTA scores: opt: 399, E(): 2e-19, (58.7% identity in 109 FT aa overlap); Rv0731c, Rv0726c, etc. Frame-shift could occur FT at nt 817866. Same sequence for strain CDC1551 and FT Mycobacterium bovis." FT /db_xref="UniProtKB/TrEMBL:Q79FX1" FT /protein_id="CAE55313.1" FT /translation="SQDRLFDNSTELSVAGSTIATELVPGIVDFDAGRVREMADSFRKH FT GVDIDMASLVYSGERSHVVDYLRAKGWDVEGTVRTDLFRRNGLPVPAPHDDDPLGEIIF FT ISGRLNG" FT CDS complement(133266..134171) FT /transl_table=11 FT /locus_tag="Rv0725c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0725c, (MTCY210.44c), len: 301 aa. Conserved FT hypothetical protein, similar to hypothetical proteins from FT Mycobacterium tuberculosis e.g. Rv0726c, Rv0731c, Rv3399, FT etc, e.g. Y893_MYCTU|Q10552|Rv0893C hypothetical 36.1 kDa FT protein cy31.21c (325 aa), FASTA scores: opt: 600, E(): FT 3.9e-32, (43.8% identity in 219 aa overlap)." FT /db_xref="GOA:P95073" FT /db_xref="InterPro:IPR003455" FT /db_xref="InterPro:IPR011610" FT /db_xref="UniProtKB/TrEMBL:P95073" FT /protein_id="CAB06449.1" FT /translation="MPRAHDDNWDLASSVGATATMVAAGRALATKDPRGLINDPFAEPL FT VRAVGLDFFTKLIDGELDIATTGNLSPGRAQAMIDGIAVRTKYFDDYFRTATDGGVRQV FT VILAAGLDARAYRLPWPAGTVVYEIDQPQVIDFKTTTLAGIGAKPTAIRRTVYIDLRAD FT WPAALQAAGLDSTAPTAWLAEGMLIYLPPDPRTGCSTTAPNSVLRAARSLPNLSRALWI FT STQAGYEKWRIRFASTAWTSTWRRWCIPANAATSSTTCAPRAGTLRAQCGPTYSGAMVC FT PFPPHTTTIRSAKSSSSAVV" FT CDS complement(134264..135367) FT /transl_table=11 FT /locus_tag="Rv0726c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0726c, (MTCY210.45c), len: 367 aa. Conserved FT hypothetical protein, highly similar to other conserved FT hypothetical proteins from Mycobacterium tuberculosis e.g. FT Q10552|Y893_MYCTU|Rv0893c|MT0917|MTCY31.21c (325 aa), FASTA FT scores: opt: 646, E(): 0, (38.3% identity in 329 aa FT overlap); Rv0731c|MTV041.05c (318 aa), Rv3399, etc. Also FT similar to proteins from Mycobacterium leprae and other FT organisms e.g. T35930 hypothetical protein SC9B5.10 from FT Streptomyces coelicolor (303 aa)." FT /db_xref="GOA:P95074" FT /db_xref="InterPro:IPR003455" FT /db_xref="InterPro:IPR011610" FT /db_xref="UniProtKB/Swiss-Prot:P95074" FT /protein_id="CAB06431.1" FT /translation="MTYTGSIRCEGDTWDLASSVGATATMVAAARAMATRAANPLINDQ FT FAEPLVRAVGVDVLTRLASGELTASDIDDPERPNASMVRMAEHHAVRTKFFDEFFMDAT FT RAGIRQVVILASGLDSRAYRLAWPAQTVVYEIDQPQVMEFKTRTLAELGATPTADRRVV FT TADLRADWPTALGAAGFDPTQPTAWSAEGLLRYLPPEAQDRLLDNVTALSVPDSRFATE FT SIRNFKPHHEERMRERMTILANRWRAYGFDLDMNELVYFGDRNEPASYLSDNGWLLTEI FT KSQDLLTANGFQPFEDEEVPLPDFFYVSARLQRKHRQYPAHRKPAPSWRHTACPVNELS FT KSAAYTMTRSDAHQASTTAPPPPGLTG" FT CDS complement(135570..136226) FT /transl_table=11 FT /gene="fucA" FT /locus_tag="Rv0727c" FT /product="POSSIBLE L-FUCULOSE PHOSPHATE ALDOLASE FUCA FT (L-FUCULOSE-1-PHOSPHATE ALDOLASE)" FT /function="INVOLVED IN FUCOSE METABOLISM (AT THE THIRD FT STEP) [CATALYTIC ACTIVITY: L-FUCULOSE 1-PHOSPHATE = FT GLYCERONE PHOSPHATE + (S)-LACTALDEHYDE]." FT /EC_number="4.1.2.17" FT /note="Rv0727c, (MTV41.01c, MTCY210.46c), len: 218 aa. FT Possible fucA, L-fuculose-1-phosphate aldolase (EC FT 4.1.2.17), similar to many e.g. NP_386339.1|NC_003047 FT PUTATIVE L-FUCULOSE PHOSPHATE ALDOLASE PROTEIN from FT Sinorhizobium meliloti (222 aa); P11550|FUCA_ECOLI FT L-FUCULOSE PHOSPHATE ALDOLASE from Escherichia strain K12 FT (215 aa), FASTA scores: opt: 372, E(): 4.1e-19, (34.6% FT identity in 185 aa overlap); etc. BELONGS TO THE ALDOLASE FT CLASS II FAMILY, ARAD/FUCA SUBFAMILY. COFACTOR: BINDS ONE FT ZINC ION PER MOLECULE. TBparse score is 0.878." FT /db_xref="GOA:P95075" FT /db_xref="HSSP:1JDI" FT /db_xref="InterPro:IPR001303" FT /db_xref="UniProtKB/TrEMBL:P95075" FT /protein_id="CAB06473.1" FT /translation="MNFVDAPESAVLAAAKDMLRRGLVEGTAGNISARRSDGNVVITPS FT SVDYAEMLLHDLVLVDAGGAVLHAKDGRSPSTELNLHLACYRAFDDIGSVIHSHPVWAT FT MFAVAHEPIPACIDEFAIYCGGDVRCTEYAASGTPEVGRNAVRALEGRAAALIANHGLV FT AVGPRPDQVLRVTALVERTAQIVWGARALGGPVPIPEDVCRNFTGVYGYLRANPL" FT CDS complement(136223..137203) FT /transl_table=11 FT /gene="serA2" FT /locus_tag="Rv0728c" FT /product="POSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA2 FT (PHOSPHOGLYCERATE DEHYDROGENASE) (PGDH)" FT /function="INVOLVED AT THE FIRST COMMITTED STEP IN THE FT 'PHOSPHORYLATED' PATHWAY OF L-SERINE BIOSYNTHESIS. FT CATALYZES THE OXIDATION OF D-3-PHOSPHOGLYCERATE TO FT 3-PHOSPHOHYDROXYPYRUVATE [CATALYTIC ACTIVITY: FT 3-PHOSPHOGLYCERATE + NAD(+) = 3-PHOSPHOHYDROXYPYRUVATE + FT NADH]." FT /EC_number="1.1.1.95" FT /note="Rv0728c, (MTV041.02c), len: 326 aa. Possible serA2, FT D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95), similar FT to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate FT dehydrogenase from Bacillus subtilis (344 aa), FASTA FT scores: opt: 594, E(): 3.1e-31, (35.9% identity in 309 aa FT overlap); etc. Also similar to Rv2996c|MTV012.10|SERA1 FT D-3-phosphoglycerate dehydrogenase from Mycobacterium FT tuberculosis (528 aa). TBparse score is 0.882." FT /db_xref="GOA:O86322" FT /db_xref="InterPro:IPR006139" FT /db_xref="InterPro:IPR006140" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O86322" FT /protein_id="CAB06474.1" FT /translation="MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQ FT LADRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGIPVLHTPA FT RNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGLVGL FT GAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQ FT QFAAMRDGAVFLNTARSQLRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNV FT VLTPHIGGATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS" FT CDS 137234..138580 FT /transl_table=11 FT /gene="xylB" FT /locus_tag="Rv0729" FT /product="POSSIBLE D-XYLULOSE KINASE XYLB (XYLULOKINASE) FT (XYLULOSE KINASE)" FT /function="PHOSPHORYLATES D-XYLULOSE [CATALYTIC ACTIVITY: FT ATP + D-XYLULOSE = ADP + D-XYLULOSE 5-PHOSPHATE]." FT /EC_number="2.7.1.17" FT /note="Rv0729, (MTV041.03), len: 448 aa. Possible xylB, FT D-xylulose-kinase (xylulokinase) (EC 2.7.1.17). C-terminus FT highly similar to AAD09880.1|U77912 unknown protein from FT Mycobacterium bovis (102 aa); and N-terminus highly similar FT to T45387|Z98756|MLCB2492_25 hypothetical protein from FT Mycobacterium leprae (110 aa), FASTA scores: opt: 427, E(): FT 1.1e-19, (60.9% identity in 110 aa overlap). Also similar FT to xylA/xylB genes from various bacterial species e.g. FT AAC26499.1|AF045245 D-xylulose-kinase from Klebsiella FT pneumoniae (487 aa); NP_418021.1|NC_000913 xylulokinase FT from Escherichia coli strain K12 (484 aa), FASTA scores: FT opt: 260, E(): 7.5e-09, (25.9% identity in 478 aa overlap); FT etc. Also similar to Rv3696c|glpK PROBABLE GLYCEROL KINASE FT (EC 2.7.1.30) from Mycobacterium tuberculosis (517 aa). FT BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / FT XYLULOKINASE FAMILY. TBparse score is 0.895." FT /db_xref="GOA:O53793" FT /db_xref="InterPro:IPR000577" FT /db_xref="InterPro:IPR018484" FT /db_xref="InterPro:IPR018485" FT /db_xref="UniProtKB/TrEMBL:O53793" FT /protein_id="CAA17496.1" FT /translation="MSRDDVTIGIDIGTTAVKAVAADDNGRVTARVRIGHQLAVPAPDR FT LEHDADEAWRRGPLAALDRLVGPDTRALAVAAMVPSLTAVDPAGRPITPGLLYGDARGR FT VPNASVARAQSVPSVGETAEFLRWTAGQALDASGYWPAPAVANYALSGEAVIDYATAVT FT TLPLFDGTGWNATACADCGVTVDRMPRVETFGVGVGQVRGTGAVLAVGAVDALCEQIVA FT GADRDGDVLVLCGATLIVWTTISAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVD FT RVIGPGDPALADPRRVPVWLPYIRGERTPFHEPDRRAVLDGVDLSQDAASVRRAAYEAS FT GFVVRQLIELSGAPVARIVAAGGGTRIQPWMQAIADATGRPVEVSRVAEGAALGAAFLG FT RLAAGLESSIADAARWASTDRIVEPSADWAGPTKERYRRFLALSGSKLA" FT CDS 138593..139321 FT /transl_table=11 FT /locus_tag="Rv0730" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0730, (MTV041.04), len: 242 aa. Conserved FT hypothetical protein, only equivalent to Z98756|MLCB2492_26 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (227 aa), FT FASTA scores: opt: 1180, E(): 0, (83.5% identity in 218 aa FT overlap). TBparse score is 0.899." FT /db_xref="GOA:Q7D9D7" FT /db_xref="InterPro:IPR000182" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q7D9D7" FT /protein_id="CAA17497.1" FT /translation="MHGARTGVSFYAYAMTDHDQTAARREIADALLAALERRHEVADAI FT VEAANKAAAVEAIVNLLGTSHLAAEAVMSMSFDQLTQDARTKIIAELDDLNKQLSFTVK FT ERPASSGEGLELRPFSPDEDRDIFARRTEEMGAAGDGSGGPAGSVDDEIRAAQKRVDDE FT EAAWFVAVDSGVKVGMVFGELVHGEVDVRIWIHPDHRKKGYGTAALRKSRSEMAWAFPA FT VPMVARAPAAQPAQPGSAGR" FT CDS complement(139410..140366) FT /transl_table=11 FT /locus_tag="Rv0731c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0731c, (MTV041.05c), len: 318 aa. Conserved FT hypothetical protein, highly similar to other conserved FT hypothetical proteins from Mycobacterium tuberculosis e.g. FT Rv0726c|MTCY210.45c (367 aa), FASTA score: (60.9% identity FT in 317 aa overlap); Rv3399, Rv1729c, etc. TBparse score is FT 0.880." FT /db_xref="GOA:Q7D9D6" FT /db_xref="InterPro:IPR003455" FT /db_xref="InterPro:IPR011610" FT /db_xref="UniProtKB/Swiss-Prot:Q7D9D6" FT /protein_id="CAA17498.1" FT /translation="MTQTGSARFEGDSWDLASSVGLTATMVAAARAVAGRAPGALVNDQ FT FAEPLVRAVGVDFFVRMASGELDPDELAEDEANGLRRFADAMAIRTHYFDNFFLDATRA FT GIRQAVILASGLDSRAYRLRWPAGTIVFEVDQPQVIDFKTTTLAGLGAAPTTDRRTVAV FT DLRDDWPTALQKAGFDNAQRTAWIAEGLLGYLSAEAQDRLLDQITAQSVPGSQFATEVL FT RDINRLNEEELRGRMRRLAERFRRHGLDLDMSGLVYFGDRTDARTYLADHGWRTASAST FT TDLLAEHGLPPIDGDDAPFGEVIYVSAELKQKHQDTR" FT CDS 140527..141852 FT /transl_table=11 FT /gene="secY" FT /locus_tag="Rv0732" FT /product="PROBABLE PREPROTEIN TRANSLOCASE SECY" FT /function="ESSENTIAL FOR PROTEIN EXPORT. INTERACTS WITH FT SECA|Rv3240c AND SECE|Rv0638 TO ALLOW THE TRANSLOCATION OF FT PROTEINS ACROSS THE PLASMA MEMBRANE, BY FORMING PART OF A FT CHANNEL." FT /note="Rv0732, (MTV041.06), len: 441 aa. Probable SecY, FT preprotein translocase (integral membrane protein) (see FT citation below), equivalent to NP_302243.1|NC_002677 SecY FT subunit of preprotein translocase from Mycobacterium leprae FT (438 aa); AAC04389.1|AF047021 preprotein translocase FT subunit from Mycobacterium smegmatis (438 aa); and FT U77912|MBU77912_1 preprotein translocase subunit from FT Mycobacterium bovis (441 aa), FASTA scores: opt: 2802, E(): FT 0, (99.8% identity in 441 aa overlap). Also highly similar FT to others e.g. P46785|SECY_STRCO PREPROTEIN TRANSLOCASE FT SECY SUBUNIT from Streptomyces coelicolor (437 aa); etc. FT Contains PS00755 and PS00756 protein secY signatures 1 and FT 2. BELONGS TO THE SECE/SEC61-ALPHA FAMILY. PART OF THE FT PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE FT SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, FT SECG|Rv1440 AND SECY." FT /db_xref="GOA:P0A5Z2" FT /db_xref="InterPro:IPR002208" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Z2" FT /protein_id="CAA17499.1" FT /translation="MLSAFISSLRTVDLRRKILFTLGIVILYRVGAALPSPGVNFPNVQ FT QCIKEASAGEAGQIYSLINLFSGGALLKLTVFAVGVMPYITASIIVQLLTVVIPRFEEL FT RKEGQAGQSKMTQYTRYLAIALAILQATSIVALAANGGLLQGCSLDIIADQSIFTLVVI FT VLVMTGGAALVMWMGELITERGIGNGMSLLIFVGIAARIPAEGQSILESRGGVVFTAVC FT AAALIIIVGVVFVEQGQRRIPVQYAKRMVGRRMYGGTSTYLPLKVNQAGVIPVIFASSL FT IYIPHLITQLIRSGSGVVGNSWWDKFVGTYLSDPSNLVYIGIYFGLIIFFTYFYVSITF FT NPDERADEMKKFGGFIPGIRPGRPTADYLRYVLSRITLPGSIYLGVIAVLPNLFLQIGA FT GGTVQNLPFGGTAVLIMIGVGLDTVKQIESQLMQRNYEGFLK" FT misc_feature 140749..140808 FT /note="PS00755 Protein secY signature 1" FT misc_feature 141052..141108 FT /note="PS00756 Protein secY signature 2" FT CDS 141849..142394 FT /transl_table=11 FT /gene="adk" FT /locus_tag="Rv0733" FT /product="PROBABLE ADENYLATE KINASE ADK (ATP-AMP FT TRANSPHOSPHORYLASE)" FT /function="THIS SMALL UBIQUITOUS ENZYME IS ESSENTIAL FOR FT MAINTENANCE AND CELL GROWTH [CATALYTIC ACTIVITY: ATP + AMP FT = ADP + ADP]." FT /EC_number="2.7.4.3" FT /note="Rv0733, (MTV041.07), len: 181 aa. Probable adk, FT adenylate kinase (ATP-AMP transphosphorylase) (EC 2.7.4.3), FT equivalent to Z98756|MLCB24 92_28 probable adenylate kinase FT from Mycobacterium leprae (181 aa), FASTA scores: opt: 978, FT E(): 0, (83.6% identity in 177 aa overlap); and FT AAF86323.1|AF271342 putative adenylate kinase from FT Mycobacterium marinum (124 aa) (N-terminus shorter). Also FT highly similar to others e.g. P43414|KAD_STRCO ADENYLATE FT KINASE from Streptomyces coelicolor (217 aa), FASTA score: FT (43.0% identity in 186 aa overlap); etc. Contains PS00113 FT Adenylate kinase signature. BELONGS TO THE ADENYLATE KINASE FT FAMILY. TBparse score is 0.869." FT /db_xref="GOA:P69440" FT /db_xref="InterPro:IPR000850" FT /db_xref="InterPro:IPR006259" FT /db_xref="PDB:1P4S" FT /db_xref="PDB:2CDN" FT /db_xref="UniProtKB/Swiss-Prot:P69440" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17500.1" FT /translation="MRVLLLGPPGAGKGTQAVKLAEKLGIPQISTGELFRRNIEEGTKL FT GVEAKRYLDAGDLVPSDLTNELVDDRLNNPDAANGFILDGYPRSVEQAKALHEMLERRG FT TDIDAVLEFRVSEEVLLERLKGRGRADDTDDVILNRMKVYRDETAPLLEYYRDQLKTVD FT AVGTMDEVFARALRALGK" FT misc_feature 142089..142124 FT /note="PS00113 Adenylate kinase signature" FT CDS 142397..143197 FT /transl_table=11 FT /gene="mapA" FT /locus_tag="Rv0734" FT /standard_name="map" FT /product="PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) FT (PEPTIDASE M) (MetAP)" FT /function="REMOVES THE AMINO-TERMINAL METHIONINE FROM FT NASCENT PROTEINS [CATALYTIC ACTIVITY: L-METHIONYLPEPTIDE + FT H2O = L-METHIONINE + PEPTIDE]." FT /EC_number="3.4.11.18" FT /note="Rv0734, (MTV041.08), len: 266 aa. Probable mapA, FT methionine aminopeptidase (map) (EC 3.4.11.18), equivalent FT to Z98756|MLCB2492_29 probable methionine aminopeptidase FT from Mycobacterium leprae (266 aa), FASTA scores: opt: FT 1717, E(): 0, (83.4% identity in 265 aa overlap). Also FT highly similar to many e.g. T35553 methionine FT aminopeptidase from Streptomyces coelicolor (278 aa); etc. FT Also similar to Rv2861c|MAPB PROBABLE METHIONINE FT AMINOPEPTIDASE from Mycobacterium tuberculosis (285 aa). FT BELONGS TO PEPTIDASE FAMILY M24A; ALSO KNOWN AS THE MAP FT FAMILY 1. COFACTOR: COBALT; BINDS 2 IONS PER SUBUNIT. FT TBparse score is 0.893." FT /db_xref="GOA:Q7D9D5" FT /db_xref="HSSP:1O0X" FT /db_xref="InterPro:IPR000994" FT /db_xref="InterPro:IPR001714" FT /db_xref="InterPro:IPR002467" FT /db_xref="UniProtKB/TrEMBL:Q7D9D5" FT /protein_id="CAE55314.1" FT /translation="MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPG FT TSSLSLDEIAESVIRESGATPSFLGYHGYPASICASINDRVVHGIPSTAEVLAPGDLVS FT IDCGAVLDGWHGDAAITFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAHAIE FT TGTRAAELRYGRSFGIVAGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPML FT TLGTTKTVVLDDKWTVTTADGSRAAHWEHTVAVTDDGPRILTLG" FT CDS 143270..143803 FT /transl_table=11 FT /gene="sigL" FT /locus_tag="Rv0735" FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGL" FT /function="THE SIGMA FACTOR IS AN INITIATION FACTOR THAT FT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC FT INITIATION SITES AND THEN IS RELEASED." FT /note="Rv0735, (MTV041.09), len: 177 aa. Probable sigL, FT alternative RNA polymerase sigma factor (rpoE) (see FT citations below), highly similar to many proteins of the FT extracytoplasmatic function (ECF) subfamily e.g. FT CAB72200.1|AL138851 putative RNA polymerase sigma factor FT from Streptomyces coelicolor (194 aa); Q06909|CARQ_MYXXA FT RNA POLYMERASE SIGMA FACTOR CARQ from Myxococcus xanthus FT (174 aa), FASTA scores: opt: 251, E(): 9.6e-11, (32.9% FT identity in 161 aa overlap); etc. Also similar to MTCI61_4, FT MTU87242_1, and MLU15180_30 from Mycobacterium FT tuberculosis. Contains PS01063 Sigma-70 factors ECF FT subfamily signature and probable helix-turn helix motif FT from aa 139-160 (Score 1134, +3.05 SD). BELONGS TO THE FT SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. TBparse score is FT 0.902." FT /db_xref="GOA:Q7D9D4" FT /db_xref="InterPro:IPR000838" FT /db_xref="InterPro:IPR007627" FT /db_xref="InterPro:IPR007630" FT /db_xref="InterPro:IPR013324" FT /db_xref="InterPro:IPR013325" FT /db_xref="InterPro:IPR014284" FT /db_xref="UniProtKB/TrEMBL:Q7D9D4" FT /protein_id="CAA17502.1" FT /translation="MARVSGAAAAEAALMRALYDEHAAVLWRYALRLTGDAAQAEDVVQ FT ETLLRAWQHPEVIGDTARPARAWLFTVARNMIIDERRSARFRNVVGSTDQSGTPEQSTP FT DEVNAALDRLLIADALAQLSAEHRAVIQRSYYRGWSTAQIATDLGIAEGTVKSRLHYAV FT RALRLTLQELGVTR" FT misc_feature 143387..143425 FT /note="PS01063 Sigma-70 factors ECF subfamily signature" FT CDS 143867..144619 FT /transl_table=11 FT /locus_tag="Rv0736" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0736, (MTV041.10), len: 250 aa. Probable conserved FT membrane protein, showing weak similarity with FT AL133469|SCM10_32 putative membrane protein from FT Streptomyces coelicolor (216 aa), FASTA scores: opt: 180, FT E(): 0.00018, (34.3% identity in 216 aa overlap). TBparse FT score is 0.911." FT /db_xref="UniProtKB/TrEMBL:Q7D9D3" FT /protein_id="CAA17503.1" FT /translation="MTMPLRGLGPPDDTGVREVSTGDDHHYAMWDAAYVLGALSAADRR FT EFEAHLAGCPECRGAVTELCGVPALLSQLDRDEVAAISESAPTVVASGLSPELLPSLLA FT AVHRRRRRTRLITWVASSAAAAVLAIGVLVGVQGHSAAPQRAAVSALPMAQVGTQLLAS FT TVSISGEPWGTFINLRCVCLAPPYASHDTLAMVVVGRDGSQTRLATWLAEPGHTATPAG FT SISTPVDQIAAVQVVAADTGQVLLQRSL" FT CDS 144934..145431 FT /transl_table=11 FT /locus_tag="Rv0737" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0737, (MTV041.11), len: 165 aa. Possible FT transcriptional regulator, similar to others e.g. FT BAB69161.1|AB070937 regulator protein from Streptomyces FT avermitilis (169 aa); NP_419731.1|NC_002696 transcriptional FT regulator MarR family from Caulobacter crescentus (148 aa) FT (homology only at C-terminus); etc. Also shows weak FT similarity to AB0014|AB001488_14 hypothetical protein from FT Bacillus subtilis (164 aa), FASTA scores: opt: 163, E(): FT 9.3e-05, (32.8% identity in 116 aa overlap), which is FT similar to slyY gene of S. typhimurium required for FT survival in macrophage. Contains possible helix-turn helix FT motif from aa 73-94 (Score 1138, +3.06 SD). TBparse score FT is 0.888." FT /db_xref="GOA:Q7D9D2" FT /db_xref="InterPro:IPR000835" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7D9D2" FT /protein_id="CAA17504.1" FT /translation="MASDNRDPIAAARANWERSGWGDVSLGMVAVTSVMRAHQILLARV FT ETALRPYDLSFSRFELLRLLAFSRIGALPITKASDRLQVHVTSVTHAIRRLEADGLVRR FT VPHPTDGRTTLVQITELGRSTVEDATVTLNEQVFANVGMGAEESQALVSAVETLRRNAG FT DF" FT CDS 145789..146337 FT /transl_table=11 FT /locus_tag="Rv0738" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0738, (MTV041.12), len: 182 aa. Conserved FT hypothetical protein, showing weak similarity with FT hypothetical proteins from Mycobacterium tuberculosis: FT Rv1727|MTCY04C12.12 (189 aa); MTY13D12_7|Z80343 FT hypothetical protein from Mycobacterium tuberculosis (194 FT aa), FASTA scores: opt: 172, E(): 0.0004, (24.2% identity FT in 178 aa overlap); and C-terminus of Rv0576. TBparse score FT is 0.886." FT /db_xref="InterPro:IPR017517" FT /db_xref="InterPro:IPR017520" FT /db_xref="UniProtKB/TrEMBL:O53801" FT /protein_id="CAA17505.1" FT /translation="MDPLMAHQRAQDAFAALLANVRADQLGGPTPCSEWTINDLIEHVV FT GGNEQVGRWAASPIEPPARPDGLVAAHQAAAAVAHEIFAAPGGMSATFKLPLGEVPGQV FT FIGLRTTDVLTHAWDLAAATGQSTDLDPELAVERLAAARALVGPQFRGPGKPFADEKPC FT PRERPPADQLAAFLGRTVR" FT CDS 146582..147388 FT /transl_table=11 FT /locus_tag="Rv0739" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0739, (MTV041.13), len: 268 aa. Conserved FT hypothetical protein, showing some similarity to FT Mycobacterium tuberculosis proteins Rv0026 (448 aa), FASTA FT score: (37.6% identity in 101 aa overlap)and Rv0025 (120 FT aa), FASTA score: (32.4% identity in 142 aa overlap). FT TBparse score is 0.942." FT /db_xref="InterPro:IPR019710" FT /db_xref="UniProtKB/Swiss-Prot:O53802" FT /protein_id="CAA17506.1" FT /translation="MVLTRRAREVALTQHIGVSAETDRAVVPKLRQAYDSLVCGRRRLG FT AIGAEIENAVAHQRALGLDTPAGARNFSRFLATKAHDITRVLAATAAESQAGAARLRSL FT ASSYQAVGFGPKPQEPPPDPVPFPPYQPKVWAACRARGQDPDKVVRTFHHAPMSARFRS FT LPAGDSVLYCGNDKYGLLHIQAKHGRQWHDIADARWPSAGNWRYLADYAIGATLAYPER FT VEYNQDNDTFAVYRRMSLPDGRYVFTTRVIISARDGKIITAFPQTT" FT CDS 147503..148030 FT /transl_table=11 FT /locus_tag="Rv0740" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0740, (MTV041.14), len: 175 aa. Conserved FT hypothetical protein; C-terminus (possibly part of FT truncated IS1557) shows nearly perfect identity to FT Rv0750|MTV041_24 (81 aa), FASTA score: (92.6% identity in FT 81 aa overlap). Also shows weak similarity to MTV007_5 FT hypothetical protein from Mycobacterium tuberculosis (313 FT aa), FASTA score: (34.5% identity in 110 aa overlap); and FT MLCL536_27 hypothetical protein from Mycobacterium leprae FT (315 aa), FASTA score: (34.5% identity in 84 aa overlap). FT TBparse score is 0.909." FT /db_xref="UniProtKB/TrEMBL:O53803" FT /protein_id="CAA17507.1" FT /translation="MLPKNTRPTSETAEEFWDNSLWCSWGDRETGYTRTVTVSICQVAD FT GEREAEGVRDMMRLECPAGLDLRTPNPEAYEITGQRPGEFVFVLGYLGHVRAIVGNCYI FT EIMPMGTRVELSKLADVALDIGRSVGCSAYENDFTLPDIPTQWRNQPLGWYTQGLAPYL FT PGLSDPKDAAEG" FT repeat_region 148079..148595 FT /mobile_element="insertion sequence:IS1557'-1" FT /note="IS1557'-1, len: 517 bp. Region similar to Insertion FT sequence IS1557 on MTCY373- (IS1557- 1st copy)." FT CDS 148261..148575 FT /transl_table=11 FT /locus_tag="Rv0741" FT /product="PROBABLE TRANSPOSASE (FRAGMENT)" FT /function="REQUIRED FOR THE TRANSPOSITION OF THE INSERTION FT ELEMENT IS1557." FT /note="Rv0741, (MTV041.15), len: 104 aa. Probable truncated FT transposase for IS1557, showing similarity to transposases FT and IS elements e.g. U63997|EFU63997_1 insertion sequence FT from Enterococcus faecium (424 aa), FASTA score: (31.0% FT identity in 87 aa overlap). Very high similarity with the FT C-terminal part of Z73419|MTCY373_3 2 IS1557 from FT Mycobacterium tuberculosis (444 aa), FASTA score: (86.5% FT identity in 104 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O53804" FT /protein_id="CAA17508.1" FT /translation="MFSVKGEEGKQALDRWISWARRCRIPVFVELAGGIVRHRQAIDAA FT LDHGLWQGLIESTNTKIRLLTRIAFGFRSPEALIALAMLALGGRRPALPGRTKHPRISQ FT " FT CDS 148708..149235 FT /transl_table=11 FT /gene="PE_PGRS8" FT /locus_tag="Rv0742" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0742, (MTV041.16), len: 175 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to many FT Mycobacterium tuberculosis PGRS-type proteins e.g. FT Z78020|MTCY1A11_25 (498 aa), FASTA scores: opt: 766, E(): FT 6.1e-25, (73.6% identity in 178 aa overlap). Similarity FT suggests ORF starts with ATA start codon. TBparse score is FT 0.846." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FW9" FT /protein_id="CAE55315.1" FT /translation="MSFVIAAPEAIAAAATDLASIGSTIGAANAAAAANTTAVLAAGAD FT QVSVAIAAAFGAHGQAYQALSAQAATFHIQFVQALTAGAGSYAAAEAASAASITSPLLD FT AINAPFLAALGRPLIGNGADGAPGTGAAGGAGGLLFGNGGAGGSGAPGGAGGLLFGNGG FT AGGPGASGGALG" FT CDS complement(149613..150170) FT /transl_table=11 FT /locus_tag="Rv0743c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0743c, (MTV041.17c), len: 185 aa. Hypothetical FT unknown protein. TBparse score is 0.918." FT /db_xref="UniProtKB/TrEMBL:O53806" FT /protein_id="CAA17510.1" FT /translation="MTRQQLAHLLRRACAVVGDVDVLVLGSQSILGSFDENELPPQATA FT SQEADIAFVNDPARDKADHVDVAIGEMSDFHRSNGVYAEGVHIDTAILPNGWRDRLVSW FT TVESSRPAKPRFLEPHDLAVAKLAAGREKDKAFVAALIRSGLLDVGVIQARVLLLPEET FT DPRIGQRIAAWLNYYGAGNHSS" FT CDS complement(150167..150673) FT /transl_table=11 FT /locus_tag="Rv0744c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="THOUGHT TO BE INVOLVED IN TRANSCRIPTIONAL FT MECHANISM." FT /note="Rv0744c, (MTV041.18c), len: 168 aa. Possible FT transcriptional regulator, showing weak similarity with FT O86661|SC4A2.05 PUTATIVE TWO-COMPONENT SENSOR from FT Streptomyces coelicolor (436 aa), FASTA scores: opt: 117, FT E(): 0.88, (37.25% identity in 94 aa overlap); and some FT putative excisionases or transposases. Also weakly similar FT to P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (114 FT aa); and Q11144|Y477_MYCTU|Rv0477|MT0495|MTCY20G9.03 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (148 aa). Equivalent to AAK45006 from FT Mycobacterium tuberculosis strain CDC1551 (179 aa) but FT shorter 11 aa. Contains probable helix-turn helix motif FT from aa 5-26 (Score 1350, +3.78 SD). TBparse score is FT 0.925." FT /db_xref="GOA:O53807" FT /db_xref="InterPro:IPR009061" FT /db_xref="InterPro:IPR010093" FT /db_xref="UniProtKB/TrEMBL:O53807" FT /protein_id="CAA17511.1" FT /translation="METLLKTSEAAQILGVSRQHVVNMCDRGEMVCVHVGSHRRVPSSE FT VERVTSRRLTREEERSLWLHRALLSPLLTEPDTVVSAARENLRRWSGMHRRDGMAGWYF FT TKWQRVLNDGLDAVMHVLTSPSEDAREMRQNSPFAGILPEATRVAVLRSFKDHWDREHE FT RAMTE" FT CDS 150881..151408 FT /transl_table=11 FT /locus_tag="Rv0745" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0745, (MTV041.19), len: 175 aa. Conserved FT hypothetical protein; shows high similarity to a 50 aa FT region of Rv3649|Z95436|MTY15C10_3 CONSERVED HYPOTHETICAL FT PROTEIN, similar to ATP-dependent helicases, from FT Mycobacterium tuberculosis (771 aa), FASTA scores: opt: FT 225, E(): 7e-06, (70.0% identity in 50 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O53808" FT /protein_id="CAA17512.1" FT /translation="MGPPHRSRPPLPSPGPTCQVLPTTAVIHTVTAEALGRIGIDAPRI FT PGSLDVAAHAAIGLLPLVAGCDRRHRRPVRGARAGRAAQVSLCMTAIRVEPVSSNAVCT FT GPAAQVGDQSRSPQRDYAHQALQPDVPRRRARRHRPRRCSAKTGSSSSTMRCTCHQNQC FT LWSSGVSWALAR" FT CDS 151428..153779 FT /transl_table=11 FT /gene="PE_PGRS9" FT /locus_tag="Rv0746" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0746, (MTV041.20), len: 783 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. FT tuberculosis (914 aa), FASTA scores: opt: 2429, E(): 0, FT (56.9% identity in 873 aa overlap). Also similar to other FT PE-PGRS FAMILY PROTEINS e.g. AL0212|MTV008_46 FASTA score: FT (48.8% identity in 887 aa overlap); etc. TBparse score is FT 0.860." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79FW8" FT /protein_id="CAE55316.1" FT /translation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transl_table=11 FT /gene="PE_PGRS10" FT /locus_tag="Rv0747" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0747, (MTV041.21), len: 801 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. FT tuberculosis (914 aa), FASTA scores: opt: 2772, E(): 0, FT (60.9% identity in 941 aa overlap). Also similar to other FT PE-PGRS FAMILY PROTEINS e.g. Z95844|MTCY493_2 FASTA score: FT (50.2% identity in 815 aa overlap). Contains PS00012 FT Phosphopantetheine attachment site." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:O53810" FT /protein_id="CAE55317.1" FT /translation="MSWVMVSPELVVAAAADLAGIGSAISSANAAAAVNTTGLLTAGAD FT EVSTAIAALFGAQGQAYQAASAQAAAFYAQFVQALSAGGGAYAAAEAAAVSPLLAPINA FT QFVAATGRPLIGNGANGAPGTGANGGPGGWLIGNGGAGGSGAPGAGAGGNGGAGGLFGS FT GGAGGASTDVAGGAGGAGGAGGNAGMLFGAAGVGGVGGFSNGGATGGAGGAGGAGGLFG FT AGRERGSGGSGNLTGGAGGAGGNAGTLATGDGGAGGTGGASRSGGFGGAGGAGGDAGMF FT FGSGGSGGAGGISKSVGDSAAGGAGGAPGLIGNGGNGGNGGASTGGGDGGPGGAGGTGV FT LIGNGGNGGSGGTGATLGKAGIGGTGGVLLGLDGFTAPASTSPLHTLQQDVINMVNDPF FT QTLTGRPLIGNGANGTPGTGADGGAGGWLFGNGGNGGQGTIGGVNGGAGGAGGAGGILF FT GTGGTGGSGGPGATGLGGIGGAGGAALLFGSGGAGGSGGAGAVGGNGGAGGNAGALLGA FT AGAGGAGGAGAVGGNGGAGGNGGLFANGGAGGPGGFGSPAGAGGIGGAGGNGGLFGAGG FT TGGAGGGSTLAGGAGGAGGNGGLFGAGGTGGAGSHSTAAGVSGGAGGAGGDAGLLSLGA FT SGGAGGSGGSSLTAAGVVGGIGGAGGLLFGSGGAGGSGGFSNSGNGGAGGAGGDAGLLV FT GSGGAGGAGASATGAATGGDGGAGGKSGAFGLGGDGGAGGATGLSGAFHIGGKGGVGGS FT AVLIGNGGNGGNGGNSGNAGKSGGAPGPSGAGGAGGLLLGENGLNGLM" FT misc_feature 156098..156145 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS 156674..156931 FT /transl_table=11 FT /locus_tag="Rv0748" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0748, (MTV041.22), len: 85 aa. Conserved FT hypothetical protein, N-terminus similar to N-terminal FT region of NP_436939.1|NC_003078 HYPOTHETICAL PROTEIN from FT Sinorhizobium meliloti (75 aa). Also similar to FT Mycobacterium tuberculosis proteins Rv2871 CONSERVED FT HYPOTHETICAL PROTEIN (75 aa); Rv1241, Rv2132, Rv3321c, etc. FT TBparse score is 0.875." FT /db_xref="GOA:O53811" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/TrEMBL:O53811" FT /protein_id="CAA17515.1" FT /translation="MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGG FT ARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLELNSRK" FT CDS 156955..157383 FT /transl_table=11 FT /locus_tag="Rv0749" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0749, (MTV041.23), len: 142 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins from Mycobacterium tuberculosis e.g. Rv0749, FT Rv0277c, Rv2530c, etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="InterPro:IPR006226" FT /db_xref="UniProtKB/TrEMBL:O53812" FT /protein_id="CAA17516.1" FT /translation="MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWA FT SFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHLPTNPGPRHLMLLRKLCDEADASGD FT LIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL" FT CDS complement(157464..157601) FT /transl_table=11 FT /locus_tag="Rv0749A" FT /product="HYPOTHETICAL PROTEIN (FRAGMENT)" FT /function="UNKNOWN" FT /note="Rv0749A, len: 45 aa. Conserved hypothetical protein FT (probably gene fragment), similar to part (aa 250-292) of FT Rv2807|Z81331_12 from Mycobacterium tuberculosis (384 aa), FT FASTA scores: opt: 238, E(): 1.9e-13, (79.07% identity in FT 43 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q8VKE7" FT /protein_id="CAE55318.1" FT /translation="MVRKHAFHWRYDSTEELELLNQLWQLVSLRLNFFTPTKKALGFRP FT " FT CDS 157760..158005 FT /transl_table=11 FT /locus_tag="Rv0750" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0750, (MTV041.24), len: 81 aa. Conserved FT hypothetical protein, showing almost perfect overlap with FT C-terminus of Rv0740|MTV041_14 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (175 aa), FASTA FT scores: (93.8% identity in 81 aa overlap). Possible FT duplication. TBparse score is 0.872." FT /db_xref="UniProtKB/TrEMBL:O53813" FT /protein_id="CAA17517.1" FT /translation="MRAIVGDCVIHIMPMGTGVELSKLADLALDIGRSVGCSAYENDFT FT LPDIPTQWRNQPLGWYTQGLAPYLPGLSDPKDAAEG" FT CDS complement(158074..158958) FT /transl_table=11 FT /gene="mmsB" FT /locus_tag="Rv0751c" FT /product="PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB FT (HIBADH)" FT /function="Catalyzes the NAD-dependent, reversible FT oxidation of 3-hydroxbutyrate to methylmalonate [CATALYTIC FT ACTIVITY: 3-hydroxy-2-methylpropanoate + NAD+ = FT 2-methyl-3-oxopropanoate + NADH]." FT /EC_number="1.1.1.31" FT /note="Rv0751c, (MTV041.25c), len: 294 aa. Probable mmsB, FT 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31), highly FT similar to others e.g. NP_102847.1|NC_002678 FT 3-hydroxyisobutyrate dehydrogenase from Mesorhizobium loti FT (294 aa); NP_420167.1|NC_002696 3-hydroxyisobutyrate FT dehydrogenase from Caulobacter crescentus (298 aa); A32867 FT 3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus FT (346 aa); etc. Also similar to methylmalonate semialdehyde FT dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate FT semialdehyde dehydrogenase from Pseudomonas aeruginosa (298 FT aa), FASTA scores: opt: 786, E(): 0, (45.8% identity in 297 FT aa overlap). Also similar to 6-phosphogluconate FT dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122 FT and Rv1844c. Contains PS00895 3-hydroxyisobutyrate FT dehydrogenase signature. BELONGS TO THE FT 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY." FT /db_xref="GOA:P63935" FT /db_xref="InterPro:IPR002204" FT /db_xref="InterPro:IPR006115" FT /db_xref="InterPro:IPR008927" FT /db_xref="InterPro:IPR011548" FT /db_xref="InterPro:IPR013328" FT /db_xref="InterPro:IPR015815" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P63935" FT /protein_id="CAA17518.1" FT /translation="MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGV FT AVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHA FT LAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGA FT GQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGP FT VPTSPANNDFKPGFSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDF FT SAVIHTLRARADA" FT misc_feature complement(158899..158943) FT /note="PS00895 3-hydroxyisobutyrate dehydrogenase FT signature" FT CDS complement(158969..160141) FT /transl_table=11 FT /gene="fadE9" FT /locus_tag="Rv0752c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE9" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv0752c, (MTV041.26c), len: 390 aa. Probable fadE9, FT acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to FT many e.g. NP_437985.1|NC_003078 putative acyl-CoA FT dehydrogenase protein from Sinorhizobium meliloti (380 aa); FT Z99123|BSUB0020_14 from Bacillus subtilis (379 aa), FASTA FT scores: opt: 853, E(): 0, (39.8% identity in 384 aa FT overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases FT signature 1, and PS00073 Acyl-Co Adehydrogenases signature FT 2. BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY." FT /db_xref="GOA:O53815" FT /db_xref="HSSP:1BUC" FT /db_xref="InterPro:IPR006089" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006091" FT /db_xref="InterPro:IPR006092" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR013764" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:O53815" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17519.1" FT /translation="MFVLNDDERVIVETAAAFAGKRLAPHALEWDAAKHFPVDVLREAA FT ELGMAAIYCRDDVGGSGLRRLDGVRIFEQLAIADPVTAAFLSIHNMCAWMIDSFGTDEQ FT RKDWIPRLATMGVIASYCLTEPGAGSDAGALSTRAVRHGSGKGGDYVLDGVKQFISGAA FT ASDVYVVMARTGAEGPRGVSAFIVEKGTPGLSFGAPEAKMGWHAQPTAQVVLDGVRVPA FT EAMLGGADGEGAGFGIAMSGLNGGRLNIAACSLGGAQAAFDKAGAYVRDRQAFGGSLLD FT EPTVRFTLADMATGLQTSRMLLWRAASALDDDDADKVELCAMAKRYVTDTCFEVADQAL FT QLHGGYGYLREYGLEKIVRDLRVHRILEGTNEIMRLVIGRAEAARFRATV" FT misc_feature complement(159062..159121) FT /note="PS00073 Acyl-CoA dehydrogenases signature 2" FT misc_feature complement(159740..159778) FT /note="PS00072 Acyl-CoA dehydrogenases signature 1" FT CDS complement(160148..161680) FT /transl_table=11 FT /gene="mmsA" FT /locus_tag="Rv0753c" FT /product="PROBABLE METHYLMALONATE-SEMIALDEHYDE FT DEHYDROGENASE MMSA (METHYLMALONIC ACID SEMIALDEHYDE FT DEHYDROGENASE) (MMSDH)" FT /function="PLAYS A ROLE IN VALINE AND PYRIMIDINE FT METABOLISM. BINDS FATTY ACYL-CoA [CATALYTIC ACTIVITY: FT 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 FT + NADH]." FT /EC_number="1.2.1.27" FT /note="Rv0753c, (MTV041.27c), len: 510 aa. Probable mmsA, FT methylmalonic acid semialdehyde dehydrogenase (EC FT 1.2.1.27), highly similar to others e.g. FT NP_420115.1|NC_002696 putative methylmalonate-semialdehyde FT dehydrogenase from Caulobacter crescentus (499 aa); FT L48550|STMMSDA_1|CAB75315.1|AL139164 methylmalonic acid FT semialdehyde dehydrogenase from Streptomyces coelicolor FT (500 aa), FASTA score: (51.6% identity in 498 aa overlap); FT M84911|PSEMMSRAB_2|NP_252260.1|NC_002516 FT methylmalonate-semialdehyde dehydrogenase from Pseudomonas FT aeruginosa (497 aa), FASTA scores: opt: 1127, E(): 0, FT (47.9% identity in 507 aa overlap); etc. Note that also FT highly similar to malonic semialdehyde oxidative FT decarboxylases e.g. NP_104968.1|NC_002678 malonic FT semialdehyde oxidative decarboxylase from Mesorhizobium FT loti (498 aa); NP_384832.1|NC_003047 PUTATIVE MALONIC FT SEMIALDEHYDE OXIDATIVE DECARBOXYLASE PROTEIN from FT Sinorhizobium meliloti (498 aa); etc. Contains PS00070 FT Aldehyde dehydrogenases cysteine active site. BELONGS TO FT THE ALDEHYDE DEHYDROGENASES FAMILY." FT /db_xref="GOA:O53816" FT /db_xref="HSSP:1O04" FT /db_xref="InterPro:IPR010061" FT /db_xref="InterPro:IPR015590" FT /db_xref="InterPro:IPR016160" FT /db_xref="InterPro:IPR016161" FT /db_xref="InterPro:IPR016162" FT /db_xref="UniProtKB/TrEMBL:O53816" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17520.1" FT /translation="MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDID FT AAVASAVEAQKGWAAWNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQ FT RGIEVIEFCLGIPHLLKGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGP FT ALACGNAFVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAV FT GFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGER FT CMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQ FT GVAAGAELVVDGRDRASDDLTFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGP FT VLCMVRARDYEEALRLPSEHEYGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVA FT YHTFGGWKRSGFGDLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS" FT misc_feature complement(160823..160858) FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT CDS 161886..163640 FT /transl_table=11 FT /gene="PE_PGRS11" FT /locus_tag="Rv0754" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0754, (MTV041.28), len: 584 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), similar to others FT e.g. AL0212|MTV008_46 from Mycobacterium tuberculosis (1660 FT aa), FASTA score: (48.7% identity in 345 aa overlap); FT Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa), FT FASTA score: (41.6% identity in 442 aa overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/TrEMBL:Q79FW5" FT /protein_id="CAE55319.1" FT /translation="MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAAD FT EVSAALAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGALGS FT APASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTGTAA FT APNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMGNGGM FT GGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQ FT SIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLI FT RTQQTAAPLANLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVP FT MLAPGSTDVNGIVFNRAFTGAVQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMN FT VDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTLVSWDGIPVGPASLPTALFVDVRELITA FT PQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGHPYLSGLP FT IGLPSLIP" FT CDS complement(163830..165767) FT /transl_table=11 FT /gene="PPE12" FT /locus_tag="Rv0755c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0755c, (MTV041.29), len: 645 aa. Member of the FT Mycobacterium tuberculosis PPE family, highly similar to FT others e.g. Z82098|MTCY3C7_23 from Mycobacterium FT tuberculosis (582 aa), FASTA scores: (56.1% identity in 636 FT aa overlap); Z92774|MTCY6G11_5 from Mycobacterium FT tuberculosis (552 aa), FASTA scores: (55.8% identity in 590 FT aa overlap); etc." FT /db_xref="HSSP:2G38" FT /db_xref="InterPro:IPR000030" FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/Swiss-Prot:Q79FW4" FT /protein_id="CAE55320.1" FT /translation="MVGFAWLPPETNSLRMYLGAGSRPLLAAAGAWDGLAEELHAAASS FT FGSVTSELAGGAWQGPASAAMANAAGPYASWLTAAGAQAELAARQARAAAGAFEEALAG FT VVHPAVVQANRVRTWLLAVSNVFGQNAPAIAAMESTYEQMWAQDVAVMAGYHAASSAAA FT AQLASWQPALPNINLGVGNIGNLNVGNGNTGDYNLGNGNLGNANFGGGNGSAFHGQISS FT FNVGSGNIGNFNLGSGNGNVGIGPSSFNVGSGNIGNANVGGGNSGDNNFGFGNFGNANI FT GIGNAGPNMSSPAVPTPGNGNVGIGNGGNGNFGGGNTGNANIGLGNVGDGNVGFGNSGS FT YNFGFGNTGNNNIGIGLTGSNQIGFGGLNSGSGNIGFGNSGTGNIGFFNSGSGNFGVGN FT SGVTNTGVANSGNINTGFGNSGFINTGFGNALSVNTGFGNSGQANTGIGNAGDFNTGNF FT NGGIINTGSFNSGAFNSGSFNGGDANSGFLNSGLTNTGFANSGNINTGGFNAGNLNTGF FT GNTTDGLGENSGFGNAGSGNSGFNNSGRGNSGAQNVGNLQISGFANSGQSVTGYNNSVS FT VTSGFGNKGTGLFSGFMSGFGNTGFLQSGFGNLEANPDNNSATSGFGNSGKQDSGGFNS FT IDFVSGFFHR" FT CDS complement(166069..166254) FT /transl_table=11 FT /locus_tag="Rv0755A" FT /product="PUTATIVE TRANSPOSASE (FRAGMENT)" FT /function="COULD BE REQUIRED FOR THE TRANSPOSITION OF AN FT INSERTION ELEMENT." FT /note="Rv0755A, len: 61 aa. Putative transposase (possibly FT gene fragment), similar to C-terminal part of FT Q9EZM2|ISMav2|AF286339_1 putative transposase from FT Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: FT 284, E(): 5e-13, (83.02% identity in 53 aa overlap); and to FT SCJ11.25c|Q9RI80 possible noncomposite transposon FT transposase from Streptomyces coelicolor (283 aa)." FT /db_xref="InterPro:IPR009057" FT /db_xref="UniProtKB/TrEMBL:Q79FW3" FT /protein_id="CAE55321.1" FT /translation="MKELSVAEQRYQAVLAVISDGLSISQVAEKVGVSRQTLHTWLARY FT EAEGLDGLRIGTGTAL" FT tRNA complement(166369..166440) FT /gene="tRNA-Thr(TGT)" FT /product="transfer RNA-Thr(TGT)" FT /anticodon=(pos:166406..166408,aa:Thr) FT CDS complement(166468..167193) FT /transl_table=11 FT /locus_tag="Rv0756c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0756c, (MTCY369.01c), len: 241 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P71813" FT /protein_id="CAB02399.1" FT /translation="MNLGQTLVGIATWPARAGLAAADTGLNMAGAAVDMAKQALGDAGG FT ASGSTSMANMLGIDDTIARANRLARLLDDDMPLGRAIAPNGPMDRMLRPGGVVDLLTQP FT GGLLDRLTAEGGAMQRALQPGGLADQLLAEDGLIERVLSEDGLADRLLAEGGLIDKITA FT KDGPLEQLADVADTLARLTPGMEALEPAIATLQDAVIALTMVVNPLSSIAERIPLPGRR FT PARRSSSRSVRSQRVVDSE" FT CDS 167335..168078 FT /transl_table=11 FT /gene="phoP" FT /locus_tag="Rv0757" FT /product="POSSIBLE TWO COMPONENT SYSTEM RESPONSE FT TRANSCRIPTIONAL POSITIVE REGULATOR PHOP" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM. PART OF FT THE TWO COMPONENT REGULATORY SYSTEM PHOP/PHOQ. THIS PROTEIN FT IS THOUGHT TO BE A POSITIVE REGULATOR FOR THE PHOSPHATE FT REGULON, REQUIRED FOR INTRACELLULAR GROWTH. TRANSCRIPTION FT OF THIS OPERON IS POSITIVELY REGULATED BY PHOB AND FT PHOR|Rv0758 WHEN PHOSPHATE IS LIMITED." FT /note="Rv0757, (MTCY369.02), len: 247 aa. Possible phoP, FT two component system response phosphate regulon FT transcriptional regulator (see citations below), highly FT similar to various transcriptional regulators e.g. FT CAC32360.1|AL583945 putative two component system response FT regulator from Streptomyces coelicolor (271 aa); T45446 FT probable two-component response regulator from FT Mycobacterium leprae (253 aa); and similar to phoP proteins FT e.g. P13792|PHOP_BACSU alkaline phosphatase synthesis FT transcription regulatory protein from Bacillus subtilis FT (240 aa), FASTA scores: opt: 594, E(): 2.3e-33, (41.0% FT identity in 234 aa overlap); etc. Also highly similar to FT Rv3765c from Mycobacterium tuberculosis (234 aa), Rv1033c FT (257 aa), RV0903c|MTCY31.31c|Q10531 (236 aa), FASTA score: FT (45.4% identity in 229 aa overlap); MTCY10G2_16 and FT MTU88959_1." FT /db_xref="GOA:P71814" FT /db_xref="HSSP:1KGS" FT /db_xref="InterPro:IPR001789" FT /db_xref="InterPro:IPR001867" FT /db_xref="InterPro:IPR011006" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:P71814" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02400.1" FT /translation="MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGF FT EVYTATNGAQALDRARETRPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTARDSL FT QDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGNKEPRNVRLTFADIELDEETH FT EVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLR FT RKIDTGEKRLLHTLRGVGYVLREPR" FT CDS 168123..169580 FT /transl_table=11 FT /gene="phoR" FT /locus_tag="Rv0758" FT /product="POSSIBLE TWO COMPONENT SYSTEM RESPONSE SENSOR FT KINASE MEMBRANE ASSOCIATED PHOR" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM. THIS PROTEIN IS THOUGHT TO BE A SENSOR KINASE FOR FT THE PHOSPHATE REGULON. TRANSCRIPTION OF THIS OPERON IS FT POSITIVELY REGULATED BY PHOB|Rv0757 AND PHOR WHEN PHOSPHATE FT IS LIMITED." FT /EC_number="2.7.-.-" FT /note="Rv0758, (MTCY369.03), len: 485 aa. Possible phoR, FT two component system response phosphate sensor kinase FT membrane-associated (EC 2.7.-.-), highly similar to various FT sensor kinases e.g. CAC32361.1|AL583945 putative two FT component system histidine kinase from Streptomyces FT coelicolor (524 aa); NP_349365.1|NC_003030 FT Membrane-associated sensory histidine kinase with HAMP FT domain from Clostridium acetobutylicum (482 aa); and FT similar to phoP proteins e.g. NP_372216.1|NC_002758 FT alkaline phosphatase synthesis sensor protein from FT Staphylococcus aureus (554 aa); P23545|PHOR_BACSU alkaline FT phosphatase synthesis sensor from Bacillus subtilis (579 FT aa), FASTA scores: opt: 515, E(): 1.9e-25, (40.0% identity FT in 230 aa overlap); etc. Also similar to proteins from FT Mycobacterium tuberculosis e.g. MTCY20G9.16 FASTA scores: FT (34.5% identity in 264 aa overlap), MTU88959_2 (509 aa), FT MTCY10G2_17, etc." FT /db_xref="GOA:P71815" FT /db_xref="HSSP:1BXD" FT /db_xref="InterPro:IPR003594" FT /db_xref="InterPro:IPR003660" FT /db_xref="InterPro:IPR003661" FT /db_xref="InterPro:IPR004358" FT /db_xref="InterPro:IPR005467" FT /db_xref="InterPro:IPR009082" FT /db_xref="UniProtKB/TrEMBL:P71815" FT /protein_id="CAB02401.1" FT /translation="MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSR FT IDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSYTALNDNTAIPA FT VPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVG FT IGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLAL FT NGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAAR FT DVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPK FT RRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEV FT ADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGE FT GCCFRVSLPRVSDVDQLSLTPVVPGPP" FT CDS complement(169552..169884) FT /transl_table=11 FT /locus_tag="Rv0759c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0759c, (MTCY369.04c), len: 110 aa. Conserved FT hypothetical protein, highly similar (but shorter 45 aa in FT N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A FT HYPOTHETICAL HIT-LIKE PROTEIN from Mycobacterium leprae FT (155 aa), FASTA scores: opt: 766, E(): 0, (78.7% identity FT in 150 aa overlap). Also highly similar (but N-terminus FT always shorter) to HIT-like proteins and protein kinase FT inhibitors e.g. AAF72728.1|AF265258_1|AF265258 HIT-like FT protein from Rhodococcus sp. (141 aa); FT NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI) FT from Borrelia burgdorferi (149 aa) ; FT P94252|YHIT_BORBU|BB0379 HYPOTHETICAL HIT-LIKE PROTEIN from FT Borrelia burgdorferi (139 aa); NP_110768.1|NC_002689 HIT FT (histidine triad) family protein from Thermoplasma FT volcanium (158 aa); P16436|IPK1_BOVIN protein kinase C FT inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125 aa), FT FASTA scores: opt: 195, E(): 5.2e-08, (33.3% identity in FT 111 aa overlap); etc. Also shows similarity with FT Rv2613c|MTCY01A10.20A CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20 FT HYPOTHETICAL HIT-LIKE PROTEIN (144 aa)." FT /db_xref="GOA:P0A5B5" FT /db_xref="InterPro:IPR001310" FT /db_xref="InterPro:IPR011146" FT /db_xref="InterPro:IPR011151" FT /db_xref="InterPro:IPR019808" FT /db_xref="UniProtKB/Swiss-Prot:P0A5B5" FT /protein_id="CAB02402.1" FT /translation="MAFLTIEPMTQGHTLVVPRAEIDHWQNVDPALFGRVMSVSQLIGK FT AVCRAFSTQRAGMIIAGLEVPHLHIHVFPTRSLSDFGFANVDRNPSPGSLDEAQAKIRA FT ALAQLA" FT CDS complement(169994..170413) FT /transl_table=11 FT /locus_tag="Rv0760c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0760c, (MTCY369.05), len: 139 aa. Conserved FT hypothetical protein, similar to N-terminal part of Rv2042c FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (265 aa), FASTA scores: opt: 150, E(): FT 4.1e-05, (28.7% identity in 136 aa overlap)." FT /db_xref="GOA:P71817" FT /db_xref="InterPro:IPR002075" FT /db_xref="PDB:2A15" FT /db_xref="PDB:2Z76" FT /db_xref="PDB:2Z77" FT /db_xref="PDB:2Z7A" FT /db_xref="UniProtKB/TrEMBL:P71817" FT /protein_id="CAB02403.1" FT /translation="MTQTTQSPALIASQSSWRCVQAHDREGWLALMADDVVIEDPIGKS FT VTNPDGSGIKGKEAVGAFFDTHIAANRLTVTCEETFPSSSPDEIAHILVLHSEFDGGFT FT SEVRGVFTYRVNKAGLITNMRGYWNLDMMTFGNQE" FT CDS complement(170426..171553) FT /transl_table=11 FT /gene="adhB" FT /locus_tag="Rv0761c" FT /product="POSSIBLE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FT NAD DEPENDENT ADHB" FT /function="THOUGHT TO CATALYZE THE REVERSIBLE OXIDATION OF FT ETHANOL TO ACETALDEHYDE WITH THE CONCOMITANT REDUCTION OF FT NAD. PROBABLY ACTS ON PRIMARY OR SECONDARY ALCOHOLS OR FT HEMIACETALS [CATALYTIC ACTIVITY: An alcohol + NAD+ = an FT aldehyde or ketone + NADH]." FT /EC_number="1.1.1.1" FT /note="Rv0761c, (MTCY369.06c), len: 375 aa. Possible adhB, FT zinc-containing alcohol dehydrogenase NAD-dependent (EC FT 1.1.1.1), similar to others e.g. AAC15839.1|AF060871_4 FT hypothetical alcohol dehydrogenase from Rhodococcus FT rhodochrous (370 aa), FASTA scores: opt: 1234, E(): 0, FT (46.8% identity in 370 aa overlap); P80468|ADH2_STRCA FT ALCOHOL DEHYDROGENASE II from Struthio camelus (Ostrich) FT (379 aa); Q03505|ADH1_RABIT alcohol dehydrogenase alpha FT chain from Oryctolagus cuniculus (Rabbit) (374 aa), FASTA FT scores: opt: 872, E(): 0, (39.1% identity in 379 aa FT overlap); etc. Also similar to adhD alcohol dehydrogenase FT from Mycobacterium tuberculosis (368 aa). Contains PS00059 FT Zinc-containing alcohol dehydrogenases signature. BELONGS FT TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY." FT /db_xref="GOA:P71818" FT /db_xref="InterPro:IPR002085" FT /db_xref="InterPro:IPR002328" FT /db_xref="InterPro:IPR011032" FT /db_xref="InterPro:IPR013149" FT /db_xref="InterPro:IPR013154" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P71818" FT /protein_id="CAE55322.1" FT /translation="MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHH FT LVTGDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSCQAGMRN FT LCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVPFEV FT ACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEW FT KRDQALKFGATHVYPDINAALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGG FT TCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDD FT MVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR" FT misc_feature complement(171329..171373) FT /note="PS00059 Zinc-containing alcohol dehydrogenases FT signature" FT CDS complement(171652..172197) FT /transl_table=11 FT /locus_tag="Rv0762c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0762c, (MTCY369.07c), len: 181 aa. Conserved FT hypothetical protein, showing weak similarity to FT D90907_77|P73575 HYPOTHETICAL 31.3KD PROTEIN from FT Synechocystis sp, FASTA scores: E(): 0.0012, (30.4% FT identity in 92 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="UniProtKB/TrEMBL:P71819" FT /protein_id="CAB02392.1" FT /translation="MAGYPRDELEDVVHRWLQANRTAERRGDWTLLADFYTDDATYGWN FT VGPNEDVMCVGIDEIRDIALGQEMDGLQGWRYPYQRVVIDEKQGEVVGFWKQVATDANG FT AEQEVYGIGGSWFRYAGGGKWNWQRDFFDFGHVSALYLELIKAGKLSPGMQKRIERAVS FT GNKVPGYYPLGKTPVPLW" FT misc_feature complement(171670..171693) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(172200..172406) FT /transl_table=11 FT /locus_tag="Rv0763c" FT /product="POSSIBLE FERREDOXIN" FT /function="FERREDOXINS ARE IRON-SULFUR PROTEINS THAT FT TRANSFER ELECTRONS IN A WIDE VARIETY OF METABOLIC FT REACTIONS. PROBABLY INVOLVED IN ELECTRON TRANSPORT FOR FT CYTOCHROME P-450 SYSTEM." FT /note="Rv0763c, (MTCY369.08c), len: 68 aa. Possible FT ferredoxin, similar to others and related proteins e.g. FT P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from FT Streptomyces griseolus (68 aa); FT AAK31349.1|AF350429_2|AF350429 putative ferredoxin from FT Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 FT phthalate dioxygenase ferredoxin subunit from Arthrobacter FT keyseri (64 aa); etc. Probably involved in electron FT transport for cytochrome P-450 system e.g. downstream ORF FT Rv0764c|MTCY369.09c PROBABLE CYTOCHROME P450 51 from FT Mycobacterium tuberculosis (451 aa), FASTA scores: opt: FT 137, E(): 0.00013, (36.4% identity in 66 aa overlap). Also FT similar to putative ferredoxins Rv3503c and Rv1786 from FT Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL FT TYPE FERREDOXIN FAMILY." FT /db_xref="HSSP:1ROF" FT /db_xref="InterPro:IPR010693" FT /db_xref="UniProtKB/TrEMBL:P71820" FT /protein_id="CAB02393.1" FT /translation="MGYRVEADRDLCQGHAMCELEAPEYFRVPKRGQVEILDPEPPEEA FT RGVIKHAVWACPTQALSIRETGE" FT CDS complement(172409..173764) FT /transl_table=11 FT /gene="cyp51" FT /locus_tag="Rv0764c" FT /product="CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1) FT (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA FT DEMETHYLASE) (P450-14DM)" FT /function="INVOLVED IN STEROL BIOSYNTHESIS. ITS PRECISE FT BIOLOGICAL SUBSTRATE IS NOT KNOWN. CATALYZES FT C14-DEMETHYLATION OF LANOSTEROL, 24,25-DIHYDROLANOSTEROL FT AND OBTUSIFOLIOL WHICH IS CRITICAL FOR ERGOSTEROL FT BIOSYNTHESIS. IT TRANSFORMS LANOSTEROL INTO 4,4'-DIMETHYL FT CHOLESTA-8,14,24-TRIENE-3-BETA-OL." FT /EC_number="1.14.14.-" FT /note="Rv0764c, (MT0788, MTCY369.09c), len: 451 aa. cyp51, FT cytochrome P450 51 (sterol 14-alpha demethylase) (EC FT 1.14.14.-), similar to others e.g. Q16850|CP51_HUMAN FT CYTOCHROME P450 51 (CYPL1) (P450L1) (STEROL 14-ALPHA FT DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Homo FT sapiens (509 aa), FASTA scores: opt: 848, E(): 0, (33.9% FT identity in 439 aa overlap); NP_172633.1|NC_003070 putative FT obtusifoliol 14-alpha demethylase from Arabidopsis thaliana FT (488 aa); P93596|CP51_WHEAT CYTOCHROME P450 51 (CYPL1) FT (P450-L1A1) (OBTUSIFOLIOL 14-ALPHA DEMETHYLASE) from FT Triticum aestivum (453 aa); etc. Also similar to many other FT Mycobacterium tuberculosis cytochromes P450 e.g. Rv1394c, FT FASTA score: (22.5% identity in 444 aa overlap). Contains FT PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P0A512" FT /db_xref="InterPro:IPR001128" FT /db_xref="InterPro:IPR002403" FT /db_xref="InterPro:IPR017972" FT /db_xref="InterPro:IPR017973" FT /db_xref="PDB:1E9X" FT /db_xref="PDB:1EA1" FT /db_xref="PDB:1H5Z" FT /db_xref="PDB:1U13" FT /db_xref="PDB:1X8V" FT /db_xref="PDB:2BZ9" FT /db_xref="PDB:2CI0" FT /db_xref="PDB:2CIB" FT /db_xref="PDB:2VKU" FT /db_xref="PDB:2W09" FT /db_xref="PDB:2W0A" FT /db_xref="PDB:2W0B" FT /db_xref="UniProtKB/Swiss-Prot:P0A512" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02394.1" FT /translation="MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQL FT AGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAA FT LRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDG FT RFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSD FT RDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAA FT VIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIH FT EGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAF FT AIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV" FT misc_feature complement(172577..172606) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(173764..174591) FT /transl_table=11 FT /locus_tag="Rv0765c" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM, POSSIBLY ELECTRON TRANSFERT." FT /EC_number="1.-.-.-" FT /note="Rv0765c, (MTCY369.10c), len: 275 aa. Probable FT oxidoreductase (EC 1.-.-.-), similar others e.g. FT P39071|DHBA_BACSU 2,3-dihydro-2,3-dihydroxybenzoate FT dehydrogenase from Bacillus subtilis (261 aa), FASTA FT scores: opt: 385, E(): 1.8e-17, (30.6% identity in 252 aa FT overlap); AAF81239.1|AF263012 putative beta-ketoacyl FT reductase from Streptomyces griseus (274 aa); FT NP_436514.1|NC_003037 putative oxidoreductase from FT Sinorhizobium meliloti (240 aa); etc. Also similar to FT several other oxidoreductases from Mycobacterium FT tuberculosis e.g. Rv1544|MTCY48.21, FASTA score: (32.6% FT identity in 267 aa overlap); etc. Contains PS00061 FT Short-chain alcohol dehydrogenase family signature." FT /db_xref="GOA:P71821" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P71821" FT /protein_id="CAB02395.1" FT /translation="MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMD FT KLAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQTVEALGEVELLVSSAGDMLPGQLH FT EVSTEAFAEQVQIHLVGANRLATAVLPAMVARRRGDLIFVGSDVGLRQRPHMGAYGAAK FT AGLAAMVTNLQMELEGTGVRASIVHPGPTLTGMGWQLSAEQVGPMLADWAKWGQARHNY FT FLRPSDLARAIAFVAETPRGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG" FT misc_feature complement(174070..174156) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS complement(174591..175799) FT /transl_table=11 FT /gene="cyp123" FT /locus_tag="Rv0766c" FT /product="PROBABLE CYTOCHROME P450 123 CYP123" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv0766c, (MT0790, MTCY369.11c), len: 402 aa. FT Probable cyp123, cytochrome P-450 (EC 1.14.-.-), similar to FT others e.g. P33271|CPXK_SACER cytochrome P-450 107B1 from FT Saccharopolyspora erythraea (405 aa), FASTA scores: opt: FT 770, E(): 0, (36.9% identity in 406 aa overlap); T36526 FT probable cytochrome P450 hydroxylase from Streptomyces FT coelicolor (411 aa); P27632|CPXM_BACSU CYTOCHROME P450 109 FT from Bacillus subtilis (405 aa); etc. Also similar to FT several other cytochromes P-450 from Mycobacterium FT tuberculosis e.g. Rv1256c|MTCY50.26 (405 aa), FASTA score: FT (35.2% identity in 389 aa overlap); etc. Contains PS00086 FT Cytochrome P450 cysteine heme-iron ligand signature. FT BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P63707" FT /db_xref="InterPro:IPR001128" FT /db_xref="InterPro:IPR002397" FT /db_xref="InterPro:IPR017972" FT /db_xref="InterPro:IPR017973" FT /db_xref="UniProtKB/Swiss-Prot:P63707" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02396.1" FT /translation="MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNFW FT AVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKG FT FTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARI FT RALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAELDGD FT RLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLR FT YDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKL FT VSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISV FT QAR" FT misc_feature complement(174744..174773) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(175796..176437) FT /transl_table=11 FT /locus_tag="Rv0767c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0767c, (MTCY369.12c), len: 213 aa. Conserved FT hypothetical protein, showing weak similarity with FT AL133220|SCC75A_26 HYPOTHETICAL PROTEIN from Streptomyces FT coelicolor (215 aa), FASTA scores: opt: 152, E(): 0.0048, FT (28.4% identity in 204 aa overlap)." FT /db_xref="GOA:P67432" FT /db_xref="InterPro:IPR001647" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/Swiss-Prot:P67432" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02397.1" FT /translation="MSSDVLVTTPAQRQTEPHAEAVSRNRRQQATFRKVLAAAMATLRE FT KSYADLTVRLVAARAKVAPATAYTYFSSKNHLIAEVYLDLVRQVPCVTDVNVPMPIRVT FT SSLRHLALVVADEPEIGAACTAALLDGGADPAVRAVRDRIGAEIHRRITSAIGPGADPG FT TVFALEMAFFGALVQAGSGTFTYHEIADRLGYVVGLILAGANEPSTGGSE" FT CDS 176639..178108 FT /transl_table=11 FT /gene="aldA" FT /locus_tag="Rv0768" FT /product="PROBABLE ALDEHYDE DEHYDROGENASE NAD DEPENDENT FT ALDA (ALDEHYDE DEHYDROGENASE [NAD+])" FT /function="OXIDIZES A VARIETY OF ALDEHYDES [CATALYTIC FT ACTIVITY: An aldehyde + NAD+ + H2O = an acid + NADH]." FT /EC_number="1.2.1.-" FT /note="Rv0768, (MTCY369.13), len: 489 aa. Probable aldA, FT NAD-dependent aldehyde dehydrogenase (EC 1.2.1.-), highly FT similar to others e.g. AAL14238.1|AY052630 6-oxolauric acid FT dehydrogenase from Rhodococcus ruber (474 aa); FT NP_285450.1|NC_001264 aldehyde dehydrogenase from FT Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570 FT NADP-dependent aldehyde dehydrogenase from Bacillus FT halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde FT dehydrogenase precursor from Atriplex hortensis (Mountain FT spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6% FT identity in 486 aa overlap); etc. Also highly similar to FT Rv0223c ALDEHYDE DEHYDROGENASE from Mycobacterium FT tuberculosis (487 aa). Contains PS00687 Aldehyde FT dehydrogenases glutamic acid active site. BELONGS TO THE FT ALDEHYDE DEHYDROGENASES FAMILY." FT /db_xref="GOA:P71823" FT /db_xref="HSSP:1AG8" FT /db_xref="HSSP:1O04" FT /db_xref="InterPro:IPR015590" FT /db_xref="InterPro:IPR016160" FT /db_xref="InterPro:IPR016161" FT /db_xref="InterPro:IPR016162" FT /db_xref="UniProtKB/TrEMBL:P71823" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02398.1" FT /translation="MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAE FT DMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTA FT SAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRTLAREAVGVVGAITPWNFPH FT QINLAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGA FT LLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDDADLAAASAVS FT AFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQ FT RDRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGLTNDARVAREEIFGPVLT FT VIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPF FT GGYKQSGIGREMGLLGFEEYLEAKLIATAAN" FT misc_feature 177410..177433 FT /note="PS00687 Aldehyde dehydrogenases glutamic acid active FT site" FT CDS 178139..178885 FT /transl_table=11 FT /locus_tag="Rv0769" FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0769, (MTCY369.14), len: 248 aa. Probable FT dehydrogenase/reductase (EC 1.-.-.-), similar to others, FT especially short-chain type dehydrogenases/reductases and FT 3-oxoacyl-(acyl-carrier protein) reductases e.g. FT NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa); FT NP_243357.1|NC_002570 3-oxoacyl-(acyl-carrier protein) FT reductase from Bacillus halodurans (246 aa); FT P28643|FABG_CUPLA 3-OXOACYL-[ACYL-CARRIER PROTEIN] FT REDUCTASE from Cuphea lanceolata (320 aa); FT P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from FT Escherichia coli (255 aa), FASTA scores: opt: 536, E(): FT 6.5e-27, (37.7% identity in 247 aa overlap); etc. Also FT similar to others from Mycobacterium tuberculosis e.g. FT MTCY02B10.14, FASTA score: (33.7% identity in 249 aa FT overlap); etc." FT /db_xref="GOA:P71824" FT /db_xref="HSSP:1AHI" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR002198" FT /db_xref="InterPro:IPR002347" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P71824" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02381.1" FT /translation="MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVA FT KQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLTVP FT LDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGVNGL FT TQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMC FT LFLLSDSASWITGQIFNVDGGQIIRS" FT repeat_region 178882..178982 FT /note="101 bp Mycobacterial Interspersed Repetitive Unit, FT Class I" FT CDS 178983..179870 FT /transl_table=11 FT /locus_tag="Rv0770" FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; 3-HYDROXYISOBUTYRATE DEHYDROGENASE FT FAMILY PROTEIN PROBABLY INVOLVED IN CELLULAR METABOLISM." FT /EC_number="1.1.1.-" FT /note="Rv0770, (MTCY369.15), len: 295 aa. Probable FT dehydrogenase/reductase, 3-hydroxyisobutyrate dehydrogenase FT family (EC 1.1.1.-), possibly 3-hydroxyisobutyrate FT dehydrogenase (EC 1.1.1.31) or 2-hydroxy-3-oxopropionate FT reductase (EC 1.1.1.60), similar to others e.g. FT P23523|GARR_ECOLI 2-HYDROXY-3-OXOPROPIONATE REDUCTASE FT (TARTRONATE SEMIALDEHYDE REDUCTASE) (TSAR) from Escherichia FT coli strain K12 (294 aa), FASTA scores: opt: 469, E(): FT 6.7e-22, (34.4% identity in 282 aa overlap); FT P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase FT (HIBADH) from Pseudomonas aeruginosa (298 aa), FASTA FT scores: opt: 439, E(): 4.3e-20, (34.9% identity in 269 aa FT overlap); etc. Also similar to others from Mycobacterium FT tuberculosis e.g. Rv1122 and Rv1844c. SEEMS TO BELONG TO FT THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY." FT /db_xref="GOA:P71825" FT /db_xref="InterPro:IPR002204" FT /db_xref="InterPro:IPR006115" FT /db_xref="InterPro:IPR008927" FT /db_xref="InterPro:IPR013328" FT /db_xref="InterPro:IPR015815" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P71825" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02382.1" FT /translation="MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAP FT FVEGGATAAASVSDVAEADIISITVFDDAQVSSVITADNGLATHAKPGTIVAIHSTIAD FT TTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGADDEAFQRIKEPFSRWASLL FT IHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEACGLDLVALGKVVRHSDSFTGGAG FT AIMFRNTTAPMEPADPLRPLLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAG FT LGVPHPDTEPAKET" FT CDS 179867..180301 FT /transl_table=11 FT /locus_tag="Rv0771" FT /product="POSSIBLE 4-CARBOXYMUCONOLACTONE DECARBOXYLASE FT (CMD)" FT /function="INVOLVED IN AROMATIC HYDROCARBONS CATABOLISM. FT THOUGHT TO BE INVOLVED IN THE CATABOLISM OF PROTOCATECHUATE FT TO SUCCINATE-AND ACETYL-CoA IN THE BETA-KETOADIPATE PATHWAY FT (AT THE THIRD STEP) [CATALYTIC ACTIVITY: FT 2-CARBOXY-5-OXO-2,5-DIHYDROFURAN-2-ACETATE = FT 5-OXO-4,5-DIHYDROFURAN-2-ACETATE + CO(2)]." FT /EC_number="4.1.1.44" FT /note="Rv0771, (MTCY369.16), len: 144 aa. Possible FT 4-carboxymuconolactone decarboxylase (EC 4.1.1.44), showing FT similarity with other carboxymuconolactone decarboxylases FT e.g. AAD39557.1|AF031417 PcaC-like protein from Pseudomonas FT putida (130 aa); P20370|DC4C_ACICA 4-CARBOXYMUCONOLACTONE FT DECARBOXYLASE (CMD) from Acinetobacter sp. ADP1 (134 aa), FT FASTA scores: opt: 174, E(): 0.00075, (31.4% identity in FT 121 aa overlap); C-terminus of NP_421214.1|NC_002696 FT 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone FT decarboxylase from Caulobacter crescentus (393 aa); FT C-terminus of T47115 probable 4-carboxymuconolactone FT decarboxylase / 3-oxoadipate enol-lactone hydrolase from FT Streptomyces sp (373 aa); NP_407104.1|NC_003143 putative FT gamma carboxymuconolactone decarboxylase from Yersinia FT pestis (131 aa); etc." FT /db_xref="GOA:P71826" FT /db_xref="InterPro:IPR003779" FT /db_xref="UniProtKB/TrEMBL:P71826" FT /protein_id="CAB02383.1" FT /translation="MMDELRRTGLDKMNEVYAWDMPDMPGEFFALTVDHLFGRIWTRPG FT LSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELTIDELRELAVFITHYVGFPLGSR FT LNSAIERVAAKRKQAAENGSLPDTKANVAEVLAKESGKSS" FT CDS 180313..181581 FT /transl_table=11 FT /gene="purD" FT /locus_tag="Rv0772" FT /product="PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD FT (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) FT (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) FT (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE)" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT SECOND STEP) [CATALYTIC ACTIVITY: ATP + FT 5-PHOSPHORIBOSYLAMINE + GLYCINE = ADP + PHOSPHATE + FT 5'-PHOSPHORIBOSYLGLYCINAMIDE]." FT /EC_number="6.3.4.13" FT /note="Rv0772, (MTCY369.17), len: 422 aa. Probable purD, FT phosphoribosylamine--glycine ligase (EC 6.3.4.13), FT equivalent to Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08 FT PHOSPHORIBOSYLAMINE--GLYCINE LIGASE from Mycobacterium FT leprae (422 aa), FASTA scores: opt: 2272, E(): 0, (81.8% FT identity in 422 aa overlap). Also highly similar to others FT e.g. CAB56348.1|AL118514 phosphoribosylamine-glycine ligase FT from Streptomyces coelicolor (416 aa); P1564|PUR2_ECOLI FT phosphoribosylamine--glycine ligase from Escherichia coli FT (429 aa), FASTA scores: opt: 1039, E(): 0, (42.7% identity FT in 431 aa overlap); etc. BELONGS TO THE GARS FAMILY." FT /db_xref="GOA:P65893" FT /db_xref="InterPro:IPR000115" FT /db_xref="InterPro:IPR011054" FT /db_xref="InterPro:IPR011761" FT /db_xref="InterPro:IPR013815" FT /db_xref="InterPro:IPR013816" FT /db_xref="InterPro:IPR013817" FT /db_xref="InterPro:IPR016185" FT /db_xref="InterPro:IPR020559" FT /db_xref="InterPro:IPR020560" FT /db_xref="InterPro:IPR020561" FT /db_xref="InterPro:IPR020562" FT /db_xref="UniProtKB/Swiss-Prot:P65893" FT /protein_id="CAB02384.1" FT /translation="MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQHD FT VDITSAEAVVALAREVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPGKDAARIEGSKA FT FAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPAGDPAWVVKDDRLAAGKGVVVTAD FT RDVARAHGAALLEAGHPVLLESYLDGPEVSLFCVVDRTVVVPLLPAQDFKRVGEDDTGL FT NTGGMGAYAPLPWLPDNIYREVVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVV FT EFNCRFGDPETQAVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPG FT RPRVGDVVVGSEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAHAYEILSS FT IRLPGGHFRSDIGLRAAEGKISV" FT CDS complement(181578..183116) FT /transl_table=11 FT /gene="ggtA" FT /locus_tag="Rv0773c" FT /product="PROBABLE BIFUNCTIONAL ACYLASE GGTA: CEPHALOSPORIN FT ACYLASE (GL-7ACA ACYLASE) + GAMMA-GLUTAMYLTRANSPEPTIDASE FT (GGT)" FT /function="BESIDES THE CEPHALOSPORIN ACYLASE I ACTIVITY FT WHICH CONVERTS GL-7ACA INTO 7-ACA; THIS ENZYME DISPLAYS FT SOME GAMMA GLUTAMYLTRANSPEPTIDASE ACTIVITY: GGT PLAYS A KEY FT ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE FT SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [CATALYTIC FT ACTIVITY 1: 7-BETA-(4-CARBOXYBUTANAMIDO)-CEPHALOSPORANIC FT ACID + H2O = 7-AMINOCEPHALOSPORANIC ACID + GLUTARIC ACID] FT [CATALYTIC ACTIVITY 2: (5-L-glutamyl)-peptide + an amino FT acid = peptide + 5-L-glutamyl-amino acid]." FT /EC_number="3.5.1.-" FT /EC_number="2.3.2.2" FT /note="Rv0773c, (MTCY369.18), len: 512 aa. Probable ggtA, FT bifunctional acylase including cephalosporin acylase (EC FT 3.5.1.-), and gamma-glutamyl transpeptidase (EC 2.3.2.2); FT highly similar to others e.g. NP_295247.1|NC_001263 FT cephalosporin acylase from Deinococcus radiodurans (535 FT aa); NP_248854.1|NC_002516 probable FT gamma-glutamyltranspeptidase from Pseudomonas aeruginosa FT (538 aa); P15557|PAC1_PSES3 ACYLASE ACY 1 [INCLUDES: FT CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE); FT GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT)] from Pseudomonas sp. FT strain SE83 (558 aa), FASTA scores: opt: 784, E(): 0, FT (34.2% identity in 526 aa overlap); FT NP_391491.1|NC_000964|Z93767|BSZ93767_6|O0521 protein FT similar to gamma-glutamyltransferase from Bacillus subtilis FT (525 aa), FASTA scores: opt: 1169, E(): 0, (40.1% identity FT in 516 aa overlap); etc. Also similar to Rv2394|ggtB from FT Mycobacterium tuberculosis. Member of GL-7ACA ACYLASES AND FT TO GGT group." FT /db_xref="GOA:P71828" FT /db_xref="InterPro:IPR000101" FT /db_xref="UniProtKB/TrEMBL:P71828" FT /protein_id="CAB02385.1" FT /translation="MPILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVVE FT PVSNGIGSDAFSIVWDGQKLHGLNASGRSPSAWTPEYFGGNAVPVLGWNSVTVPGAVSA FT WVELHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAFMPGG FT RAPKPGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLAAHRV FT DWVDTITGTYRGYTIHQIPPNGQGIVALIALGILEHFDMSSWSVDSAESVHVQIEALKL FT AFADAQACVADIDYMPVHPKRLLDKEYLRQRATLIDPKRAMPAATGIPRGGTVYLAAAD FT AAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSDFTVVPRHPNRVGPRKRPYHTIIPG FT FVTRDGAPVMSFGVMGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSFEN FT GFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLAASDPRRDGQAAAC" FT CDS complement(183167..184078) FT /transl_table=11 FT /locus_tag="Rv0774c" FT /product="PROBABLE CONSERVED EXPORTED PROTEIN" FT /function="UNKNOWN; COULD HAVE POSSIBLY A LIPOLYTIC FT ACTIVITY." FT /note="Rv0774c, (MTCY369.19c), len: 303 aa. Possible FT conserved exported protein with hydrophobic region near FT N-terminus, highly similar, except in N-terminus, to FT Rv0519c|Z97831|MTY20G10.09c|O33364 HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (300 aa), FASTA scores: FT opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). FT Contains PS00061 Short-chain alcohol dehydrogenase family FT signature, and PS00120 Lipases, serine active site. So FT could be a lipase (EC 3.1.-.-). Start changed since first FT submission (-9 aa)." FT /db_xref="InterPro:IPR000801" FT /db_xref="InterPro:IPR006311" FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/TrEMBL:P71829" FT /protein_id="CAB02386.2" FT /translation="MMARMPELSRRAVLGLGAGTVLGATSAYAIDMLLQPRTSHAAPAA FT AIGTNVPLAPTPALDPAPPAQAAPTMSTGSFVSAARAGKMTNWAIARPPGQTQALRPVI FT ALHGLGGSASAVMDGGVEQGLAQAVNAGLPPFAVVSVDGGSSYWHQRASGEDAGAMVLN FT ELIPLLDTQRLDTSRVAFLGWSMGGYGALLLGSRLGPARTAAICAVSPALWLSAGSVAP FT GSFDGPDDWSANSVFGLPALGSIPIRVDCGNSDPFYAATKQFVAQLPHPPAGGFSPGGH FT NGGFWSAQLPAELTWFAPLLTG" FT misc_feature complement(183260..183346) FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT misc_feature complement(183515..183544) FT /note="PS00120 Lipases, serine active site" FT CDS 184134..184757 FT /transl_table=11 FT /locus_tag="Rv0775" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0775, (MTCY369.20), len: 207 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins e.g. ECAE000186_11|MG1655 HYPOTHETICAL PROTEIN FT from Escherichia coli strain K-12 (178 aa), FASTA scores: FT E(): 6.4e-05, (27.2% identity in 147 aa overlap); FT P41037|BIH_ECOLI hypothetical transcriptional regulator FT from Escherichia coli (103 aa), FASTA scores: opt: 138, FT E(): 0.003, (30.9% identity in 97 aa overlap); etc." FT /db_xref="GOA:P71830" FT /db_xref="InterPro:IPR001647" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:P71830" FT /protein_id="CAB02387.1" FT /translation="MGVTAAVTPKGERRRYALVSAAAELLGEGGFEAVRHRAVARRAGL FT PLASTTYYFSSLDDLIARAVEHIGMIEVAQLRARVSALSRRRRGPETTAVVLVDLLVGE FT MSSPGLAEQLISRYERHIACTRLPDLRESMRRSLRQRAEAVAEAIERSGRSAQIELVCT FT LICAVDGSVVSALVEGRDPRAAALATVVDLIDVLAPVDQRPVPF" FT CDS complement(184711..185490) FT /transl_table=11 FT /locus_tag="Rv0776c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0776c, (MTCY369.21a), len: 259 aa. Conserved FT hypothetical protein, similar (except first 50 aa) to FT P72737|D90900_57 hypothetical protein from Synechocystis FT sp. strain PCC 6803 (261 aa), FASTA scores: opt: 337, E(): FT 1.7e-15, (30.5% identity in 266 aa overlap)." FT /db_xref="InterPro:IPR008306" FT /db_xref="UniProtKB/TrEMBL:P71831" FT /protein_id="CAB02388.1" FT /translation="MYFVGVDLAWAGRNPTGVAAVDADGCLVGVGAARDDASVLAALRP FT YVVGDCLVAFDAPLVVANRTGQRPAEAALNRDFRQFEAGAYPANTEKPEFADVPRAARL FT ARQLALDMDPLSSATRRAIEVYPHPATVALFRLPRALKYKAKPGRSVDLLKSELLRLMD FT GVEGLAQAGVRMQVAGQPDWVSLRRQVTVAQRKSDLRAAEDPIDAVVCAYVALYAQRRP FT ADVTIYGDFTTGYIVTPSLPTDFRTAPDAGRRARARR" FT CDS 185735..187153 FT /transl_table=11 FT /gene="purB" FT /locus_tag="Rv0777" FT /product="PROBABLE ADENYLOSUCCINATE LYASE PURB FT (ADENYLOSUCCINASE) (ASL) (ASASE)" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT EIGHT STEP) [CATALYTIC ACTIVITY: FT 1-(5-PHOSPHORIBOSYL)-4-(N-SUCCINO-CARBOXAMIDE) FT -5-AMINOIMIDAZOLE = FUMARATE + FT 5'-PHOSPHORIBOSYL-5-AMINO-4-IMIDAZOLECARBOXAMIDE (ALSO FT CATALYZES: N6-(1,2-DICARBOXYETHYL)AMP = FUMARATE + AMP)]." FT /EC_number="4.3.2.2" FT /note="Rv0777, (MTCY369.21b), len: 472 aa. Probable purB, FT adenylosuccinate lyase (EC 4.3.2.2), equivalent (but FT shorter 15 aa) to MLCB5.13|Z95151|g2076607|PURB FT ADENYLOSUCCINATE LYASE from Mycobacterium leprae (487 aa), FT FASTA scores: opt: 2640, E(): 0, (86.7% identity in 472 aa FT overlap). More similar to eukaryotic adenylosuccinate FT lyases than to prokaryotic adenylosuccinate lyases e.g. FT P54822|PUR8_MOUSE ADENYLOSUCCINATE LYASE from Mus musculus FT (484 aa), FASTA scores: opt: 762, E(): 0, (32.4% identity FT in 445 aa overlap); CAB99134.1|AL390188 putative FT adenylosuccino lyase (fragment) from Streptomyces FT coelicolor (362 aa); etc. Contains PS00163 Fumarate lyases FT signature. BELONGS TO THE LYASE 1 FAMILY, ADENYLOSSUCINATE FT LYASE SUBFAMILY." FT /db_xref="GOA:P71832" FT /db_xref="HSSP:1DOF" FT /db_xref="InterPro:IPR000362" FT /db_xref="InterPro:IPR004769" FT /db_xref="InterPro:IPR008948" FT /db_xref="InterPro:IPR019468" FT /db_xref="InterPro:IPR020557" FT /db_xref="UniProtKB/TrEMBL:P71832" FT /protein_id="CAB02389.1" FT /translation="MSIPNVLATRYASAEMVAIWSPEAKVVSERRLWLAVLRAQAELGV FT AVADSVLADYERVVDDVDLASISARERVLRHDVKARIEEFNALAGHEHVHKGMTSRDLT FT ENVEQLQIRRSLEVIFAHGVAAVARLAERAVSYRDLIMAGRSHNVAAQATTLGKRFASA FT AQEMMIALRRLRELIDRYPLRGIKGPMGTGQDMLDLLGGDRAALADLERRVADFLGFAT FT VFNSVGQVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELATEGFAPGQVGSSAMP FT HKMNTRSCERVNGLQVVLRGYASMVAELAGAQWNEGDVFCSVVRRVALPDSFFAVDGQI FT ETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLMAAVRAGMGRESAHRLISEHAVATA FT LAMREHGAEPDLLDRLAADPRLTLGRDALEAALADKKAFAGAAGDQVDDVVAMVDALVS FT RYPDAAKYTPGAIL" FT misc_feature 186560..186589 FT /note="PS00163 Fumarate lyases signature" FT CDS 187158..188402 FT /transl_table=11 FT /gene="cyp126" FT /locus_tag="Rv0778" FT /product="POSSIBLE CYTOCHROME P450 126 CYP126" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv0778, (MT0802, MTCY369.22), len: 414 aa. Possible FT cyp126, cytochrome P-450 (EC 1.14.-.-), similar to other FT cytochromes and related proteins e.g. FT AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from FT Streptomyces rishiriensis (407 aa); Q59723|PSECYTOCHR_1 FT cytochrome p-450 linalool 8-monooxygenase (EC 1.14.99.28) FT (lin C) from Pseudomonas incognita (406 aa), FASTA scores: FT opt: 769, E(): 0, (37.0% identity in 411 aa overlap); etc. FT Also similar to others from Mycobacterium tuberculosis e.g. FT Rv0766c, Rv2266, Rv3545c, etc. Contains PS00086 Cytochrome FT P450 cysteine heme-iron ligand signature." FT /db_xref="GOA:P63711" FT /db_xref="InterPro:IPR001128" FT /db_xref="InterPro:IPR002397" FT /db_xref="InterPro:IPR017972" FT /db_xref="InterPro:IPR017973" FT /db_xref="UniProtKB/Swiss-Prot:P63711" FT /protein_id="CAB02390.1" FT /translation="MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEHT FT PDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPRHT FT RIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLG FT VPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPADDML FT SVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRS FT DFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDR FT ADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSN FT RHTGIRHLVVELRGG" FT misc_feature 188223..188252 FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(188399..189019) FT /transl_table=11 FT /locus_tag="Rv0779c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0779c, (MTCY369.23c), len: 206 aa. Possible FT conserved transmembrane protein, equivalent to FT Z95151|MLCB5_14 O05747 conserved hypothetical protein from FT Mycobacterium leprae (206 aa), FASTA scores: opt: 902, E(): FT 0, (67.2% identity in 204 aa overlap)." FT /db_xref="GOA:P71833" FT /db_xref="UniProtKB/TrEMBL:P71833" FT /protein_id="CAB02391.1" FT /translation="MRSRFLPYATTPGRLLAQLISDITVAVWTTLWMLVGLAVHDAISI FT IGEAGRQIEIGSHGIAGNLAAAGQDAQRIPVVGDALSNPITAASQAALDIAGAGHNLDT FT TAGWLAVVLALAVAATPILAVAMPWLFLRLRFCRRKWTVTTLAATPAGRQLLALRALAN FT RPPGKLAAVSTDPVGAWRREDPATMRALAALELRAAGIPLRGD" FT CDS 189070..189963 FT /transl_table=11 FT /gene="purC" FT /locus_tag="Rv0780" FT /product="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE FT SYNTHASE PURC (SAICAR SYNTHETASE)" FT /function="INVOLVED IN DE NOVO PURINE BIOSYNTHESIS (AT THE FT SEVENTH STEP) [CATALYTIC ACTIVITY: ATP + FT 1-(5-phosphoribosyl)-4-carboxy-5-aminoimidazole + FT L-aspartate = ADP + phosphate + FT 1-(5-phosphoribosyl)-4-(N-succino-carboxamide)-5-aminoimi FT da zole]." FT /EC_number="6.3.2.6" FT /note="Rv0780, (MTCY369.24), len: 297 aa. purC, FT phosphoribosylaminoimidazole- succinocarboxamide synthase FT (EC 6.3.2.6) (see citations below), equivalent to FT MTU34957_1|PURC FT phosphoribosylaminoimidazole-succinocarboxamide synthase FT from Mycobacterium leprae (297 aa), FASTA scores: opt: FT 1986, E(): 0, (99.3% identity in 297 aa overlap). Also FT similar to others e.g. CAB56351.1|AL118514 FT phosphoribosylaminoimidazole-succinocarboxamide synthase FT from Streptomyces coelicolor (299 aa); etc. Contains FT PS01058 SAICAR synthetase signature 2. BELONGS TO THE FT SAICAR SYNTHETASE FAMILY." FT /db_xref="GOA:P0A5T4" FT /db_xref="InterPro:IPR001636" FT /db_xref="InterPro:IPR013816" FT /db_xref="InterPro:IPR018236" FT /db_xref="UniProtKB/Swiss-Prot:P0A5T4" FT /protein_id="CAB02370.1" FT /translation="MRPALSDYQHVASGKVREIYRVDDEHLLLVASDRISAYDYVLDST FT IPDKGRVLTAMSAFFFGLVDAPNHLAGPPDDPRIPDEVLGRALVVRRLEMLPVECVARG FT YLTGSGLLDYQATGKVCGIALPPGLVEASRFATPLFTPATKAALGDHDENISFDRVVEM FT VGALRANQLRDRTLQTYVQAADHALTRGIIIADTKFEFGIDRHGNLLLADEIFTPDSSR FT YWPADDYRAGVVQTSFDKQFVRSWLTGSESGWDRGSDRPPPPLPEHIVEATRARYINAY FT ERISELKFDDWIGPGA" FT misc_feature 189649..189675 FT /note="PS01058 SAICAR synthetase signature 2" FT CDS 189960..190670 FT /transl_table=11 FT /gene="ptrBa" FT /locus_tag="Rv0781" FT /standard_name="ptrBb" FT /product="PROBABLE PROTEASE II PTRBA [FIRST PART] FT (OLIGOPEPTIDASE B)" FT /function="CLEAVES PEPTIDE BONDS ON THE C-TERMINAL SIDE OF FT LYSYL AND ARGININYL RESIDUES [CATALYTIC ACTIVITY: FT HYDROLYSIS OF ARG-|-XAA AND LYS-|-XAA BONDS IN FT OLIGOPEPTIDES, EVEN WHEN P1' RESIDUE IS PROLINE]." FT /EC_number="3.4.21.83" FT /note="Rv0781, (MTCY369.25), len: 236 aa. Probable ptrBa, FT first part of protease II (EC 3.4.21.83), equivalent to FT N-terminus of NP_302455.1|NC_002677 protease II from FT Mycobacterium leprae (724 aa). Also highly similar to FT N-termini of many proteases II e.g. FT P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia FT coli strains K12 and HB101 (707 aa), FASTA scores: opt: FT 204, E(): 7.4e-07, (29.6% identity in 230 aa overlap); etc. FT ORFs Rv0782 and Rv0781 appear to be a frameshifted FT homologues of protease II, but we can find no error in the FT cosmid sequence to account for this. BELONGS TO PEPTIDASE FT FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FAMILY. FT Note that previously known as ptrBb." FT /db_xref="GOA:P71835" FT /db_xref="InterPro:IPR002470" FT /db_xref="InterPro:IPR004106" FT /db_xref="UniProtKB/TrEMBL:P71835" FT /protein_id="CAB02372.2" FT /translation="MMHRTALPSPPVAKRVQTRREHHGDVFVDPYEWLRDKDSPEVIAY FT LEAENDYTERTTAHLEPLRQKIFHEIKARTKETDLSVPTRRGNWWYYARTFEGKQYGVH FT CRCPVTDPDDWNPPEFDERTEIPGEQLLLDENVEADGHDFFALGAASVSLDDNLLAYSV FT DVVGDERYTLRFKDLRTGEQYPDEIAGIGAGVTWAADNHCLLHHRGRGLASGHSVAIPT FT RVRRIVGAGLPRSR" FT CDS 190459..192117 FT /transl_table=11 FT /gene="ptrBb" FT /locus_tag="Rv0782" FT /standard_name="ptrBa" FT /product="PROBABLE PROTEASE II PTRBB [SECOND PART] FT (OLIGOPEPTIDASE B)" FT /function="CLEAVES PEPTIDE BONDS ON THE C-TERMINAL SIDE OF FT LYSYL AND ARGININYL RESIDUES [CATALYTIC ACTIVITY: FT HYDROLYSIS OF ARG-|-XAA AND LYS-|-XAA BONDS IN FT OLIGOPEPTIDES, EVEN WHEN P1' RESIDUE IS PROLINE]." FT /EC_number="3.4.21.83" FT /note="Rv0782, (MTCY369.26), len: 552 aa. Probable ptrBb, FT second part of protease II (EC 3.4.21.83), equivalent to FT C-terminus of NP_302455.1|NC_002677 protease II from FT Mycobacterium leprae (724 aa). Also highly similar to FT N-termini of many proteases II e.g. FT P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia FT coli strains K12 and HB101 (707 aa), FASTA scores: opt: FT 1251, E(): 0, (42.7% identity in 489 aa overlap); etc. ORFs FT Rv0782 and Rv0781 appear to be a frameshifted homologues of FT protease II, but we can find no error in the cosmid FT sequence to account for this. BELONGS TO PEPTIDASE FAMILY FT S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FAMILY. Note FT that previously known as ptrBa." FT /db_xref="GOA:P71834" FT /db_xref="InterPro:IPR001375" FT /db_xref="InterPro:IPR002470" FT /db_xref="InterPro:IPR004106" FT /db_xref="UniProtKB/TrEMBL:P71834" FT /protein_id="CAB02371.2" FT /translation="MTNDIPCGSRIYAPENSTRTRSPGSERESPGQLTTTVYYTTVDAA FT WRPDTVWRYRLGSGESSERVYHEADDRFWLAVGRTRSNAYLLIAAGSSITSEVRYAHAA FT DPTAQFSVVLPRRDGVEYSVEHAVIAGQDRFLILHNDGAVNFTLVEAPVEDPARQRTLI FT AHRDDVRLDAVDALAGHLVVSYRREALPRVQLWPIGPDGNYGEPEEISFDSELMSAGLG FT PNPNWDSPKLRVGAGSFVTPVRIYDIDLVTGERTLLKEQPVLGGYRREDYVERRDWAYG FT DDGTRIPVSIVHRADIEFPAPALIYGYGAYEICEDPRFSIARLSLLDRGMVFVVAHVRG FT GGEMGRLWYENGKLLDKKNTFTDFIAVARHLVDTGLTSQQQLVALGGSAGGLLMGAVAN FT MAPDLFAGILAQVPFVDPLTTILDPSLPLTVTEWDEWGNPLNDSDVYAYVKSYSPYENV FT TAQKYPAILAMTSLNDTRVYYVEPAKWVAALRHAKTDGNSVLLKTQMHAGHGGISGRYE FT RWKETAFQYGWLLATADSDRYGGGQGNDLDGAAPA" FT CDS complement(192545..194167) FT /transl_table=11 FT /gene="emrB" FT /locus_tag="Rv0783c" FT /product="POSSIBLE MULTIDRUG RESISTANCE INTEGRAL MEMBRANE FT EFFLUX PROTEIN EMRB" FT /function="TRANSLOCASE THAT CONFERS RESISTANCE TO FT SUBSTANCES OF HIGH HYDROPHOBICITY. INVOLVED IN TRANSPORT OF FT MULTIDRUG ACROSS THE MEMBRANE (EXPORT): MULTIDRUG FT RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv0783c, (MTCY369.27c), len: 540 aa. Possible emrB, FT integral membrane drug efflux protein, member of major FT facilitator superfamily (MFS), equivalent to FT AAL16083.1|AF421382_1|AF421382 EmrB efflux protein from FT Mycobacterium avium (538 aa). Also similar to other FT membrane proteins e.g. CAB61606.1|AL133210 putative export FT protein from Streptomyces coelicolor (496 aa); FT NP_108371.1|NC_002678 efflux pump protein FarB from FT Mesorhizobium loti (511 aa); P44927|EMRB_HAEINHI0897| FT multidrug resistance protein b homologue from Haemophilus FT influenzae (510 aa), FASTA scores: opt: 706, E(): 1.3e-36, FT (30.4% identity in 408 aa overlap); etc. Also similar to FT Rv2333c|MTCY3G12.01 from Mycobacterium tuberculosis (537 FT aa), FASTA score: (28.2% identity in 408 aa overlap); and FT Rv1410c|MTCY21B4.27c from Mycobacterium tuberculosis (518 FT aa), FASTA score: (26.8% identity in 496 aa overlap). FT BELONGS TO THE MAJOR FACILITATOR FAMILY; ALSO KNOWN AS THE FT DRUG RESISTANCE TRANSLOCASE FAMILY." FT /db_xref="GOA:P71836" FT /db_xref="InterPro:IPR004638" FT /db_xref="InterPro:IPR011701" FT /db_xref="InterPro:IPR016196" FT /db_xref="UniProtKB/TrEMBL:P71836" FT /protein_id="CAB02373.1" FT /translation="MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDRLDVGLLRTA FT GVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGWAADR FT FGTRRLFMGSVLAFTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPK FT RLGRVMAVVGIPMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDR FT PAASENFDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSW FT YRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQSGVHII FT PQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFGVARQADYLPILPTGLA FT IMGMGMGCSMMPLSGAAVQTLAPHQIARGSTLISVNQQVGGSIGTALMSVLLTYQFNHS FT EIIATAKKVALTPESGAGRGAAVDPSSLPRQTNFAAQLLHDLSHAYAVVFVIATALVVS FT TLIPAAFLPKQQASHRRAPLLSA" FT CDS 194365..195051 FT /transl_table=11 FT /locus_tag="Rv0784" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0784, (MTC369.28), len: 228 aa. Conserved FT hypothetical protein, with some similarity to FT MLCB5_20|O05752 hypothetical protein from Mycobacterium FT leprae (193 aa), FASTA scores: opt: 141, E(): 0.0022, FT (36.0% identity in 114 aa overlap). Also similar to FT N-terminus of NP_253002.1|NC_002516 conserved hypothetical FT protein from Pseudomonas aeruginosa (253 aa)." FT /db_xref="UniProtKB/TrEMBL:P71837" FT /protein_id="CAB02374.1" FT /translation="MSVSGIGESTLADVDAFCAEMDARSVPVSLLVAPRMRDDYRLDRD FT PRTVDWLTGRRAAGDALVLHGYDEAATKRRRGEFAMLRAHEANLRLMAADRVLEHLGLR FT TRLFAAPGWLVSPGVRTALPANGFRLLADLHGITDLVRLTTVRARVLGIGEGFLAEPWW FT CRMVVMSAERIARRGGVVRIAVAARHLRKSGPLQAMLDAVDLAMLQGCTPMVYRWRADA FT AVLDAA" FT CDS 195067..196767 FT /transl_table=11 FT /locus_tag="Rv0785" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0785, (MTCY369.29), len: 566 aa. Conserved FT hypothetical protein, highly similar to other conserved FT hypothetical proteins e.g. NP_105777.1| NC_002678 FT hypothetical protein from Mesorhizobium loti (552 aa); FT SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein FT from Streptomyces coelicolor (557 aa); AE001863|AE001863_31 FT from Deinococcus radiodurans (554 aa), FASTA scores: opt: FT 2243, E(): 0, (61.1% identity in 550 aa overlap); FT YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa), FT FASTA scores: opt: 169, E(): 0.0014, (23.8% identity in 542 FT aa overlap); etc. Also similar to Rv1817|MTCY1A11.26c from FT Mycobacterium tuberculosis (487 aa), FASTA score: (26.7% FT identity in 587 aa overlap). And shows similarity with FT other dehydrogenases." FT /db_xref="GOA:P71838" FT /db_xref="HSSP:1D4D" FT /db_xref="InterPro:IPR003953" FT /db_xref="InterPro:IPR014614" FT /db_xref="UniProtKB/TrEMBL:P71838" FT /protein_id="CAB02375.1" FT /translation="MALTCTDMSDAVAGSDAEGLTADAIVVGAGLAGLVAACELADRGL FT RVLILDQENRANVGGQAFWSFGGLFLVNSPEQRRL |