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EBI DbfetchID BX842573; SV 1; linear; genomic DNA; STD; PRO; 342416 BP. XX AC BX842573; AL021930-AL021933; AL021942; Z77162; Z83865; Z84724-Z84725; AC Z95324; Z95558; Z96796; Z96800; Z97831; Z97991; XX DT 21-NOV-2003 (Rel. 77, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 2/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-342416 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF00059; TPP. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..342416 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT CDS 223..2118 FT /transl_table=11 FT /locus_tag="Rv0282" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0282, (MTV035.10), len: 631 aa. Conserved FT hypothetical protein, similar to Y14967|MLCB628.18c FT hypothetical protein from Mycobacterium leprae (573 aa), FT FASTA scores: opt: 916, E(): 0, (38.7% identity in 568 aa FT overlap). Also similar to Mycobacterium tuberculosis FT proteins e.g. Z94121|MTY15F10.26 (619 aa), FASTA scores: FT opt: 743, E(): 0, (29.9% identity in 612 aa overlap). FT Member of CFXQ, CBXP family - 9 members in Mycobacterium FT tuberculosis. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="GOA:O53687" FT /db_xref="InterPro:IPR000641" FT /db_xref="UniProtKB/Swiss-Prot:O53687" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17357.1" FT /translation="MAGVGEGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFATCC FT RALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQSIGVLEAASRTAT FT TAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFHLAYAAALASTGGPEEFAKANHV FT VSGITERRAGWRAARWLAVVINYRAERWSDVVKLLTPMVNDPDLDEAFSHAAKITLGTA FT LARLGMFAPALSYLEEPDGPVAVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPEN FT EQVEQALSDTSFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALLHEAELQ FT LAEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGKTTIARVVA FT KIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVATGA FT KNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRNIDFPSYTS FT HELVEIAHKMAEQRDSVFEQSALHDLEALFAKLAAESTPDTNGISRRSLDIAGNGRFVR FT NIVERSEEEREFRLDHSEHAGSGEFSDEELMTITADDVGRSVEPLLRGLGLSVRA" FT misc_feature 1375..1398 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 2115..3731 FT /transl_table=11 FT /locus_tag="Rv0283" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0283, (MTV035.11), len: 538 aa. Possible conserved FT membrane protein, similar to several hypothetical FT mycobacterial proteins e.g. Z94121|MTY15F10_16|Rv3895c from FT Mycobacterium tuberculosis (495 aa), FASTA scores: opt: FT 698, E(): 0, (37.6% identity in 492 aa overlap); Rv1782; FT Rv3450c; Rv3869; and Y14967|MLCB628_16|MLCB628.17c from FT Mycobacterium leprae (481 aa), FASTA scores: opt: 672, E(): FT 1.5e-31, (37.2% identity in 506 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="InterPro:IPR007795" FT /db_xref="UniProtKB/TrEMBL:O53688" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17358.1" FT /translation="MTNQQHDHDFDHDRRSFASRTPVNNNPDKVVYRRGFVTRHQVTGW FT RFVMRRIAAGIALHDTRMLVDPLRTQSRAVLMGVLIVITGLIGSFVFSLIRPNGQAGSN FT AVLADRSTAALYVRVGEQLHPVLNLTSARLIVGRPVSPTTVKSTELDQFPRGNLIGIPG FT APERMVQNTSTDANWTVCDGLNAPSRGGADGVGVTVIAGPLEDTGARAAALGPGQAVLV FT DSGAGTWLLWDGKRSPIDLADHAVTSGLGLGADVPAPRIIASGLFNAIPEAPPLTAPII FT PDAGNPASFGVPAPIGAVVSSYALKDSGKTISDTVQYYAVLPDGLQQISPVLAAILRNN FT NSYGLQQPPRLGADEVAKLPVSRVLDTRRYPSEPVSLVDVTRDPVTCAYWSKPVGAATS FT SLTLLAGSALPVPDAVHTVELVGAGNGGVATRVALAAGTGYFTQTVGGGPDAPGAGSLF FT WVSDTGVRYGIDNEPQGVAGGGKAVEALGLNPPPVPIPWSVLSLFVPGPTLSRADALLA FT HDTLVPDSRPARPVSAEGGYR" FT misc_feature 3024..3047 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 3728..7720 FT /transl_table=11 FT /locus_tag="Rv0284" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0284, (MTV035.12), len: 1330 aa. Possible FT conserved membrane protein, similar to products of two FT adjacent Mycobacterium leprae genes, MLCB628.16c (744 aa) FT and MLCB628.15c (597 aa); and throughout its length to FT several large Mycobacterium tuberculosis proteins: Rv3447c, FT Rv3870, Rv1784, etc. Y14967|MLCB628_ 15 (744 aa), FASTA FT scores: opt: 942, E(): 0, (33.8% identity in 730 aa FT overlap); Y14967|MLCB628_14 (597 aa), FASTA scores: opt: FT 613, E(): 3.1e-30, (31.7% identity in 615 aa overlap); FT Z94121|MTY15F10_17 (1396 aa), FASTA scores: opt: 652, E(): FT 2.2e-32, (35.4% identity in 1321 aa overlap); FT Z95389|MTCY77_19 (1236 aa), FASTA scores: opt 652, E(): FT 2.2e-32, (35.4% identity in 1321 aa overlap). Contains FT three PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:O53689" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:O53689" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17359.1" FT /translation="MSRLIFEARRRLAPPSSHQGTIIIEAPPELPRVIPPSLLRRALPY FT LIGILIVGMIVALVATGMRVISPQTLFFPFVLLLAATALYRGNDKKMRTEEVDAERADY FT LRYLSVVRDNIRAQAAEQRASALWSHPDPTALASVPGSRRQWERDPHDPDFLVLRAGRH FT TVPLATTLRVNDTADEIDLEPVSHSALRSLLDTQRSIGDVPTGIDLTKVSPITVLGERA FT QVRAVLRAWIAQAVTWHDPTVLGVALAARDLEGRDWNWLKWLPHVDIPGRLDALGPARN FT LSTDPDELIALLGPVLADRPAFTGQPTDALRHLLIVVDDPDYDLGASPLAVGRAGVTVV FT HCSASAPHREQYSDPEKPILRVAHGAIERWQTGGWQPYIDAADQFSADEAAHLARRLSR FT WDSNPTHAGLRSAATRGASFTTLLGIEDASRLDVPALWAPRRRDEELRVPIGVTGTGEP FT LMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSAERLIVIYADFKGEAG FT ADSFRDFPQVVAVISNMAEKKSLADRFADTLRGEVARREMLLREAGRKVQGSAFNSVLE FT YENAIAAGHSLPPIPTLFVVADEFTLMLADHPEYAELFDYVARKGRSFRIHILFASQTL FT DVGKIKDIDKNTAYRIGLKVASPSVSRQIIGVEDAYHIESGKEHKGVGFLVPAPGATPI FT RFRSTYVDGIYEPPQTAKAVVVQSVPEPKLFTAAAVEPDPGTVIADTDEQEPADPPRKL FT IATIGEQLARYGPRAPQLWLPPLDETIPLSAALARAGVGPRQWRWPLGEIDRPFEMRRD FT PLVFDARSSAGNMVIHGGPKSGKSTALQTFILSAASLHSPHEVSFYCLDYGGGQLRALQ FT DLAHVGSVASALEPERIRRTFGELEQLLLSRQQREVFRDRGANGSTPDDGFGEVFLVID FT NLYGFGRDNTDQFNTRNPLLARVTELVNVGLAYGIHVIITTPSWLEVPLAMRDGLGLRL FT ELRLHDARDSNVRVVGALRRPADAVPHDQPGRGLTMAAEHFLFAAPELDAQTNPVAAIN FT ARYPGMAAPPVRLLPTNLAPHAVGELYRGPDQLVIGQREEDLAPVILDLAANPLLMVFG FT DARSGKTTLLRHIIRTVREHSTADRVAFTVLDRRLHLVDEPLFPDNEYTANIDRIIPAM FT LGLANLIEARRPPAGMSAAELSRWTFAGHTHYLIIDDVDQVPDSPAMTGPYIGQRPWTP FT LIGLLAQAGDLGLRVIVTGRATGSAHLLMTSPLLRRFNDLQATTLMLAGNPADSGKIRG FT ERFARLPAGRAILLTDSDSPTYVQLINPLVDAAAVSGETQQKGSQS" FT misc_feature 5162..5185 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 6212..6235 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 7046..7069 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 7717..8025 FT /transl_table=11 FT /gene="PE5" FT /locus_tag="Rv0285" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0285, (MTV035.13), len: 102 aa. Member of the FT Mycobacterium tuberculosis PE family (see Brennan & Delogu FT 2002), similar to others e.g. AL0212|MTV012_37 from FT Mycobacterium tuberculosis (105 aa), FASTA scores: opt: FT 497, E(): 2.6e-24, (80.4% identity in 102 aa overlap); FT Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102 FT aa), FASTA scores: opt: 413, E(): 3.7e-19, (66.7% identity FT in 102 aa overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7DA36" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55265.1" FT /translation="MTLRVVPEGLAAASAAVEALTARLAAAHASAAPVITAVVPPAADP FT VSLQTAAGFSAQGVEHAVVTAEGVEELGRAGVGVGESGASYLAGDAAAAATYGVVGG" FT CDS 8028..9569 FT /transl_table=11 FT /gene="PPE4" FT /locus_tag="Rv0286" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0286, (MTV035.14), len: 513 aa. Member of the FT Mycobacterium tuberculosis PPE family, similar to others FT e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 FT aa), FASTA scores: opt: 958, E(): 0, (43.5% identity in 522 FT aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q7DA35" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55266.1" FT /translation="MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYASTA FT AELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTTAL FT AAMPTLAELAANHVIHTVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAASGA FT ALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQF FT LQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLPA FT GLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAA FT GAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVPAAAAAAA FT TRGQSRARRRRRSELRDYGDEFLDMDSDSGFGPSTGDHGAQASERGAGTLGFAGTATKE FT RRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK" FT CDS 9618..9911 FT /transl_table=11 FT /gene="esxG" FT /locus_tag="Rv0287" FT /standard_name="TB9.8" FT /product="ESAT-6 LIKE PROTEIN ESXG (CONSERVED HYPOTHETICAL FT PROTEIN TB9.8)" FT /function="UNKNOWN" FT /note="Rv0287, (MTV035.15), len: 97 aa. esxG, ESAT-6 like FT protein. PE-family related protein; distant member of the FT Mycobacterium tuberculosis PE family, similar to FT Rv3020c|AL0212|MTV012.34 (97 aa), FASTA scores: opt: 564, FT E(): 0, (91.8% identity in 97 aa overlap). Contains FT probable helix-turn-helix motif at aa 14-35 (Score 144, FT +4.11 SD). SEEMS TO BELONG TO THE ESAT6 FAMILY (see Gey Van FT Pittius et al., 2001). Note that previously known as FT TB9.8." FT /db_xref="UniProtKB/TrEMBL:O53692" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17362.1" FT /translation="MSLLDAHIPQLVASQSAFAAKAGLMRHTIGQAEQAAMSAQAFHQG FT ESSAAFQAAHARFVAAAAKVNTLLDVAQANLGEAAGTYVAADAAAASTYTGF" FT CDS 9941..10231 FT /transl_table=11 FT /gene="esxH" FT /locus_tag="Rv0288" FT /standard_name="cfp7, TB10.4" FT /product="LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7 ESXH (10 FT kDa ANTIGEN) (CFP-7) (PROTEIN TB10.4)" FT /function="UNKNOWN. MAY BE INVOLVED IN VIRULENCE." FT /note="Rv0288, (MT0301, MTV035.16), len: 96 aa. esxH, low FT molecular weight protein antigen 7 (10 kDa antigen) (CFP-7) FT (Protein TB10.4) (see citations below), ala-rich protein; FT member of mycobacterial protein family containing ESAT-6, FT very similar to MTV012_33 from Mycobacterium tuberculosis FT (96 aa), FASTA scores: opt: 566, E(): 0, (84.4% identity in FT 96 aa overlap). Alternative start codon possible position FT 351878 (see Rosenkrands et al., 2000). BELONG TO THE ESAT6 FT FAMILY (see Skjot et al., 2000; 2002; Gey Van Pittius et FT al., 2001). Note that previously known as cfp7 (alternate FT gene name: TB10.4)." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:P0A568" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17363.1" FT /translation="MSQIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQG FT DTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAMMARDTAEAAKWGG" FT CDS 10242..11129 FT /transl_table=11 FT /locus_tag="Rv0289" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0289, (MTV035.17), len: 295 aa. Conserved FT hypothetical protein, equivalent to CAC32061.1|AL583926 FT possible DNA-binding protein from Mycobacterium leprae (289 FT aa); and showing some similarity to FT Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from FT Mycobacterium tuberculosis (276 aa), FASTA scores: opt: FT 149, E(): 0.0035, (27.7% identity in 289 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O53694" FT /protein_id="CAA17364.1" FT /translation="MDATPNAVELTVDNAWFIAETIGAGTFPWVLAITMPYSDAAQRGA FT FVDRQRDELTRMGLLSPQGVINPAVADWIKVVCFPDRWLDLRYVGPASADGACELLRGI FT VALRTGTGKTSNKTGNGVVALRNAQLVTFTAMDIDDPRALVPILGVGLAHRPPARFDEF FT SLPTRVGARADERLRSGVPLGEVVDYLGIPASARPVVESVFSGPRSYVEIVAGCNRDGR FT HTTTEVGLSIVDTSAGRVLVSPSRAFDGEWVSTFSPGTPFAIAVAIQTLTACLPDGQWF FT PGQRVSRDFSTQSS" FT CDS 11176..12594 FT /transl_table=11 FT /locus_tag="Rv0290" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0290, (MTV035.18), len: 472 aa. Probable conserved FT transmembrane protein, similar to several others in FT mycobacteria e.g. Z95389|MTCY77_20|Rv3887c from FT Mycobacterium tuberculosis (467 aa), FASTA scores: opt: FT 429, E(): 5.1e-19, (28. 6% identity in 479 aa overlap); FT Rv3877; Rv1795; Rv3448; and Y14967|MLCB628_9|MLCB628.10c FT from Mycobacterium leprae (480 aa), FASTA scores: opt: 269, FT E(): 3.1e-09, (26.0% identity in 503 aa overlap). TBparse FT score is 0.892." FT /db_xref="GOA:O86362" FT /db_xref="InterPro:IPR006707" FT /db_xref="UniProtKB/TrEMBL:O86362" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17365.1" FT /translation="MSGTVMQIVRVAILADSRLTEMALPAELPLREILPAVQRLVVPSA FT QNGDGGQADSGAAVQLSLAPVGGQPFSLDASLDTVGVVDGDLLVLQPVPAGPAAPGIVE FT DIADAAMIFSTSRLKPWGIAHIQRGALAAVIAVALLATGLTVTYRVATGVLAGLLAVAG FT IAVASALAGLLITIRSPRSGIALSIAALVPIGAALALAVPGKFGPAQVLLGAAGVAAWS FT LIALMIPSAERERVVAFFTAAAVVGASVALAAGAQLLWQLPLLSIGCGLIVAALLVTIQ FT AAQLSALWARFPLPVIPAPGDPTPSAPPLRLLEDLPRRVRVSDAHQSGFIAAAVLLSVL FT GSVAIAVRPEALSVVGWYLVAATAAAATLRARVWDSAACKAWLLAQPYLVAGVLLVFYT FT ATGRYVAAFGAVLVLAVLMLAWVVVALNPGIASPESYSLPLRRLLGLVAAGLDVSLIPV FT MAYLVGLFAWVLNR" FT CDS 12591..13976 FT /transl_table=11 FT /gene="mycP3" FT /locus_tag="Rv0291" FT /product="PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE FT PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) FT (MYCOSIN-3)" FT /function="THOUGHT TO HAVE PROTEOLYTIC ACTIVITY." FT /EC_number="3.4.21.-" FT /note="Rv0291, (MTV035.19), len: 461 aa. Probable mycP3, FT membrane-anchored serine protease (mycosin) (EC 3.4.21.-) FT (see Brown et al., 2000), similar to several others in FT mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from FT Mycobacterium tuberculosis (446 aa), FASTA scores: opt: FT 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; FT Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from FT Mycobacterium leprae (446 aa), FASTA scores: opt: 1159, FT E(): 0, (43.5 identity in 446 aa overlap). Has signal FT sequence and hydrophobic stretch at C-terminus, followed by FT short positively charged segment, that seems to act as a FT membrane anchor. Contains PS00137 Serine proteases, FT subtilase family, histidine active site signature. BELONGS FT TO PEPTIDASE FAMILY S8 (ALSO KNOWN AS THE SUBTILASE FT FAMILY), PYROLYSIN SUBFAMILY." FT /db_xref="GOA:O53695" FT /db_xref="HSSP:1DBI" FT /db_xref="InterPro:IPR000209" FT /db_xref="UniProtKB/TrEMBL:O53695" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17366.1" FT /translation="MIRAAFACLAATVVVAGWWTPPAWAIGPPVVDAAAQPPSGDPGPV FT APMEQRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQLVAIIDTGVQPGPRL FT PNVDAGGDFVESTDGLTDCDGHGTLVAGIVAGQPGNDGFSGVAPAARLLSIRAMSTKFS FT PRTSGGDPQLAQATLDVAVLAGAIVHAADLGAKVINVSTITCLPADRMVDQAALGAAIR FT YAAVDKDAVIVAAAGNTGASGSVSASCDSNPLTDLSRPDDPRNWAGVTSVSIPSWWQPY FT VLSVASLTSAGQPSKFSMPGPWVGIAAPGENIASVSNSGDGALANGLPDAHQKLVALSG FT TSYAAGYVSGVAALVRSRYPGLNATEVVRRLTATAHRGARESSNIVGAGNLDAVAALTW FT QLPAEPGGGAAPAKPVADPPVPAPKDTTPRNVAFAGAAALSVLVGLTAATVAIARRRRE FT PTE" FT misc_feature 12966..12998 FT /note="PS00137 Serine proteases, subtilase family, histidin FT e active site" FT CDS 13973..14968 FT /transl_table=11 FT /locus_tag="Rv0292" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0292, (MTV035.20), len: 331 aa. Probable conserved FT transmembrane protein (has two hydrophobic segments at FT N-terminal end), equivalent to CAC32058.1|AL583926 FT conserved membrane protein from Mycobacterium leprae (339 FT aa)." FT /db_xref="GOA:O53696" FT /db_xref="UniProtKB/TrEMBL:O53696" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17367.1" FT /translation="MNPIPSWPGRGRVTLVLLAVVPVALAYPWQSTRDYVLLGVAAAVV FT IGLFGFWRGLYFTTIARRGLAILRRRRRIAEPATCTRTTVLVWVGPPASDTNVLPLTLI FT ARYLDRYGIRADTIRITSRVTASGDCRTWVGLTVVADDNLAALQARSARIPLQETAQVA FT ARRLADHLREIGWEAGTAAPDEIPALVAADSRETWRGMRHTDSDYVAAYRVSANAELPD FT TLPAIRSRPAQETWIALEIAYAAGSSTRYTVAAACALRTDWRPGGTAPVAGLLPQHGNH FT VPALTALDPRSTRRLDGHTDAPADLLTRLHWPTPTAGAHRAPLTNAVSRT" FT CDS complement(14955..16157) FT /transl_table=11 FT /locus_tag="Rv0293c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0293c, (MTV035.21c), len: 400 aa. Conserved FT hypothetical protein, similar in C-terminal part to FT Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (413 FT aa), FASTA scores: opt: 394, E(): 2.1e-17, (31.1% identity FT in 299 aa overlap). TBparse score is 0.922." FT /db_xref="UniProtKB/TrEMBL:O53697" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17368.1" FT /translation="MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVES FT SAIADVALRTAVASVLSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSFPA FT PTELPKVTSRPASPLTEWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQHWR FT HRDGPRPTLCVIHGFMGSSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFSPFSG FT FGYFTSGLSGFAEAMAQAVYDFRSIVDYLRHIGVDRIALTGISLGGYTSALLASVESRL FT EAVIPNCPVVMPAKLFDEWFPANKLVKLGLRLTNISRDELIAGLAYHGPLNYRPLLPKD FT RRMIITGLGDRMAPPEHAVTLWKQWDRCALHWFPGSHLLHVSQLDYLRRMTVFLQGLMF FT D" FT CDS 16264..17049 FT /transl_table=11 FT /gene="tam" FT /locus_tag="Rv0294" FT /product="PROBABLE TRANS-ACONITATE METHYLTRANSFERASE TAM" FT /function="POSSIBLY CATALYZES THE S-ADENOSYLMETHIONINE FT MONOMETHYL ESTERIFICATION OF TRANS-ACONITATE AT HIGH FT AFFINITY AND OF CIS-ACONITATE, ISOCITRATE, AND CITRATE AT FT LOWER VELOCITIES AND AFFINITIES." FT /EC_number="2.1.1.-" FT /note="Rv0294, (MTV035.22), len: 261 aa. Probable tam, FT trans-aconitate methyltransferase (EC 2.1.1.-), similar to FT others e.g. P76145|TAM_ECOLI|7465793|B64906|B1519 FT TRANS-ACONITATE METHYLTRANSFERASE from Escherichia coli FT strain K12 (252 aa), FASTA scores: opt: 649, E(): 0, (39.3 FT identity in 252 aa overlap). BELONGS TO THE FT METHYLTRANSFERASE SUPERFAMILY." FT /db_xref="GOA:P66885" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P66885" FT /protein_id="CAA17369.1" FT /translation="MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHLTR FT YLARRWPGAVIEALDSSPEMVAAAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWVPE FT HSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGAVVQ FT SPAYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDESWQQFRQ FT ELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG" FT CDS complement(17038..17841) FT /transl_table=11 FT /locus_tag="Rv0295c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0295c, (MTV035.23c), len: 267 aa. Conserved FT hypothetical protein, showing weak similarity with FT CAC46877.1|AL591790 CONSERVED HYPOTHETICAL PROTEIN from FT Sinorhizobium meliloti (213 aa); and FT NP_104818.1|14023999|BAB50604.1|AP00300 Protein with weak FT similarity to NodH from Mesorhizobium loti (257 aa). FT TBparse score is 0.915." FT /db_xref="InterPro:IPR015124" FT /db_xref="UniProtKB/TrEMBL:O53699" FT /protein_id="CAA17370.1" FT /translation="MSRAVRPYLVLATQRSGSTLLVESLRATGCAGEPQEFFQYLPSTG FT MAPQPREWFAGVDDDTILQLLDPLDPGTPDTATPVAWREHVRTSGRTPNGVWGGKLMWN FT QTALLQQRAAQLPDRSGDGLRAAIRDVIGNEPVFVHVHRPDVVSQAVSFWRAVQTQVWR FT GHPDPKRDSQAVYHAGAIAHIIRNLRDQENGWRAWFAEEGIDPIDIAYPVLWRNLTAIV FT ASVLDAIGQDPKLAPAPMLERQANQRSDEWVDRYRAEAPRLGLPT" FT CDS complement(17851..19248) FT /transl_table=11 FT /locus_tag="Rv0296c" FT /standard_name="atsG" FT /product="PROBABLE SULFATASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="3.-.-.-" FT /note="Rv0296c, (MTCY63.01c, MTV035.24c), len: 465 aa. FT Probable sulfatase, possibly an aryl-/steryl-sulfatase (EC FT 3.1.6.-) or a sulfamidase (sulfohydrolase) (sulphamidase) FT (EC 3.10.1.-). Similar to various hydrolases e.g. FT AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from Mus FT musculus (502 aa); FT NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 FT N-sulfoglucosamine sulfohydrolase (sulfamidase) FT (sulphamidase) from Mus musculus (502 aa); FT AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase FT from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652 FT STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) FT (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC) FT from Homo sapiens (583 aa); ARSB_FELCA|P33727 arylsulfatase FT B precursor (EC 3.1.6.1) (535 aa), FASTA scores: opt: 231, FT E(): 1.7e-08, (30.3% identity in 261 aa overlap). Also FT similarity with 4 others sulfatases in Mycobacterium FT tuberculosis. Contains sulfatases signature 1 (PS00523). FT Note that previously known as atsG." FT /db_xref="GOA:Q6MX51" FT /db_xref="InterPro:IPR017849" FT /db_xref="UniProtKB/TrEMBL:Q6MX51" FT /protein_id="CAE55267.1" FT /translation="MTSERATGQRENLLIVHWHDLGRYLGVYHHPDVYSPRLDRLAAEG FT ILFTRAHATAPLCTPSRGSLFTGRYPQSNGLVGLAHHGWEYRTGVQTLPQLLSESGWYS FT ALFGMQHETSYPKRLGFDEFDVSNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGFFET FT HRPYPHERYRPADSAAVELPDYLPDTPEVRQDVAEFYGSIATADEAVGRLLDTLADTGL FT DASTWVVFVTDHGPAFPRAKSTLYDAGTGIALIIRPPTRRAMAPRVYDELFSGVDLVPT FT LLDLLRLEVPADVEGVSHAPALLAPDTENAAVRDHVYTAKTYHDSFDPIRAIRTKEYSY FT IENYAPRPLLDLPWDIQESPAGMAVAPLVKAPRPQRELYDLRADPTETNNLLAGDDSTQ FT GVAAIAADLAVRLHDWRQRTADVIPSDFAGSRIAERYTETYLRIHRKTPTGRSAIAADR FT GIDEHCS" FT misc_feature complement(19045..19083) FT /note="PS00523 Sulfatases signature 1" FT CDS 19427..21202 FT /transl_table=11 FT /gene="PE_PGRS5" FT /locus_tag="Rv0297" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0297, (MTCY63.02), len: 591 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT others e.g. Y03A_MYCTU|Q10637 from Mycobacterium FT tuberculosis (603 aa), FASTA scores: opt: 1884, E(): 0, FT (53.7% identity in 635 aa overlap). TBparse score is FT 0.850." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q6MX50" FT /protein_id="CAE55268.1" FT /translation="MSFVIAQPEMIAAAAGELASIRSAINAANAAAAAQTTGVMSAAAD FT EVSTAVAALFSSHAQAYQAASAQAAAFHAQVVRTLTVDAGAYASAEAANAGPNMLAAVN FT APAQALLGRPLIGNGANGAPGTGQAGGDGGLLFGNGGNGGSGAPGQAGGAGGAAGFFGN FT GGNGGDGGAGANGGAGGTAGWFFGFGGNGGAGGIGVAGINGGLGGAGGDGGNAGFFGNG FT GNGGMGGAGAAGVNAVNPGLATPVTPAANGGNGLNLVGVPGTAGGGADGANGSAIGQAG FT GAGGDGGNASTSGGIGIAQTGGAGGAGGAGGDGAPGGNGGNGGSVEHTGATGSSASGGN FT GATGGNGGVGAPGGAGGNGGHVSGGSVNTAGAGGKGGNGGTGGAGGPGGHGGSVLSGPV FT GDSGNGGAGGDGGAGVSATDIAGTGGRGGNGGHGGLWIGNGGDGGAGGVGGVGGAGAAG FT AIGGHGGDGGSVNTPIGGSEAGDGGKGGLGGDGGGRGIFGQFGAGGAGGAGGVGGAGGA FT GGTGGGGGNGGAIFNAGTPGAAGTGGDGGVGGTGAAGGKGGAGGSGGVNGATGADGAKG FT LDGATGGKGNNGNPG" FT CDS 21345..21572 FT /transl_table=11 FT /locus_tag="Rv0298" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0298, (MTCY63.03), len: 75 aa. Hypothetical FT unknown protein. TBparse score is 0.891." FT /db_xref="GOA:O07225" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/TrEMBL:O07225" FT /protein_id="CAB09590.1" FT /translation="MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVA FT LRDYTAKTVPALDIDAYAQRVYQANRAAGS" FT CDS 21569..21871 FT /transl_table=11 FT /locus_tag="Rv0299" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0299, (MTCY63.04), len: 100 aa. Hypothetical FT unknown protein. Equivalent to AAK44536.1 from FT Mycobacterium tuberculosis strain CDC1551 (49 aa) but FT longer 51 aa." FT /db_xref="UniProtKB/TrEMBL:O07226" FT /protein_id="CAB09597.1" FT /translation="MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRV FT PEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPLGNAGVAALREAASVVTALLC" FT CDS 21919..22140 FT /transl_table=11 FT /locus_tag="Rv0300" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0300, (MTCY63.05), len: 73 aa. Conserved FT hypothetical protein, similar to FT Rv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 FT aa), FASTA scores: opt: 84, E(): 8.3, (39.5% identity in 38 FT aa overlap)." FT /db_xref="PDB:3H87" FT /db_xref="UniProtKB/TrEMBL:O07227" FT /protein_id="CAB09591.1" FT /translation="MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARV FT TVTAADLRRLRGAVAGLGDPELMRQAWR" FT CDS 22137..22562 FT /transl_table=11 FT /locus_tag="Rv0301" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0301, (MTCY63.06), len: 141 aa. Conserved FT hypothetical protein, similar to other hypothetical FT Mycobacterium tuberculosis proteins e.g. Rv2757c, Rv0229c, FT Rv2546, etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="PDB:3H87" FT /db_xref="UniProtKB/TrEMBL:O07228" FT /protein_id="CAB09598.1" FT /translation="MTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVG FT FSAECGEIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLLIAA FT TAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA" FT CDS 22698..23330 FT /transl_table=11 FT /locus_tag="Rv0302" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR/ACRR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0302, (MTCY63.07), len: 210 aa. Probable FT transcription regulatory protein, TetR family (see citation FT below), with its N-terminus similar to N-terminus of FT several repressors and regulatory proteins of TetR/AcrR FT family e.g. ACRR_ECOLI|P34000 potential acraB operon FT repressor from Escherichia coli (215 aa), FASTA scores: FT opt: 172, E(): 3.1e-05, (22.7% identity in 194 aa overlap). FT Also similar in N-terminus to N-terminus of MTCY07A7.24 FT hypothetical regulator from Mycobacterium tuberculosis FT FASTA score: (38.7% identity in 62 aa overlap). Contains FT probable helix-turn helix motif from aa 35-56 (Score 1728, FT +5.07 SD). TBparse score is 0.896." FT /db_xref="GOA:O07229" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:O07229" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09599.1" FT /translation="MGVPAKKKQQQGERSRESILDATERLMATKGYAATSISDIRDACG FT LAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQ FT HPDFLRLFYLLSMERSQDPAVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAE FT LTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET" FT CDS 23327..24235 FT /transl_table=11 FT /locus_tag="Rv0303" FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0303, (MTCY63.08), len: 302 aa. Possible FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT NADPH dehydrogenases and other NADPH oxidoreductases e.g. FT O48741|PORC_ARATH|7488284|T00897 PROTOCHLOROPHYLLIDE FT REDUCTASE C CHLOROPLAST PRECURSOR (EC 1.3.1.33) FT (NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE C) from FT Arabidopsis thaliana (401 aa); Q42850 NADPH DEHYDROGENASE FT (EC 1.6.99. 1) (395 aa), FASTA scores: opt: 347, E(): FT 3.8e-16, (35.4% identity in 319 aa overlap). TBparse score FT is 0.905." FT /db_xref="GOA:O07230" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O07230" FT /protein_id="CAB09592.1" FT /translation="MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDPARGRAA FT MEELGEPNRCSVLEVDLASVRSVRSFVETVRTTPLPPIRALVCNAGLQVVSGIAFTDDG FT VEMTFGVNHLGHFALVTGILDWLARPARIVVVSSGTHDPSKHTGMPDPRYTCAADLAHP FT PTDQNTPAEGRRRYTTSKLCNVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLARDYP FT PILRLAYRLLSPMLRVLPFVHSTRVSGEHLAALAVDPRFAGVTGQYFAGAKAIRSSAES FT YDRAKALDLWETSERLLAQVT" FT CDS complement(24243..30857) FT /transl_table=11 FT /gene="PPE5" FT /locus_tag="Rv0304c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0304c, (MTCY63.9c), len: 2204 aa. Member of the FT Mycobacterium tuberculosis PE family (PPE, MPTR), similar FT to others e.g. Z95324|MTY13E10_16 from Mycobacterium FT tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% FT identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from FT Mycobacterium tuberculosis (734 aa), FASTA scores: opt: FT 989, E(): 0, (42.3% identity in 522 aa overlap)." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q6MX49" FT /protein_id="CAE55269.1" FT /translation="MNLVSTTSGMSGFLNVGALGSGVANVGNTISGIYNVGTSDLSTPA FT VNSGLANIGTNIAGLLRDGAGTAAINLGLANHGNLNVGFASLGGFNFGGATIGHNNVGI FT GNTGIFDVGLANLGSYNIGFGNLGDDNLGFGNFGSYNIGFGNVGNDNLGFANAGGGNIG FT FANTGSNNVGFGNTGSNNVGIGLTGNGQIGFGSFNSGSGNIGLFNSGSNNIGFFNSGSG FT NFGIANSGSFNTGIGNTGNTNTGLFNSGDVNTGAFNPGSFNTGSFNTGSFNTGGFNPGN FT TNTGYLNIGNYNTGIANTGDVDTGAFITGNYSNGLFLSGDYQGLVGLNLVIDMPLPISL FT GVNIPIDIPITASAGNITLMGVTIPPTGDIVLSSIAGQRAHFGPITIPNITVVGPTTTV FT AIGGPNTAITITGGGAIRIPLISIPAAPGFGNSTTNPSSGFFNTGAGGASGFGNFGGAN FT SGFWNLASATSGASGLLNVGALGSGLANVGTTVSGFYNTSTSDLATPAFNSGLANISTS FT IAGLLRDSTGTMVLNLGLANHGTLNVGIANLGDYNIGFANLGSANFGSANIGGNNIGGA FT NTGIFDIGLANLGSYNIGFGNFGDDNLGFGNLGSYNVGFGNLGNDNLGFANTGSNNIGF FT ANTGSNNIGIGLTGDGQIGFGSLNSGSGNIGLFNSGSGNIGFFNSGNGNVGIGNTGTAN FT FGLGNTGSTNTGFFNSGDVNTGIGNTGSFNTGSFNPGDSNTGDFNPGSYNTGLGNTGDV FT DTGAFISGSYSNGFLWSGNYQGLIGLHAALAIPEIALTFGVDIPIHIPINIDAGVVTLQ FT GFSIVAAENNIDFTPIIIPTINITLPTAAITVGGPTTSIGITASAGIGSITIPIIDIPA FT TSGFGNSTTSPSSGFFNSGAGSASGFLNVVAGASGISGYLNVGALGSGVTNVGHTVSGF FT YNASALDLVTPAFASGLMRDGMGTMTLNLGLANLGSNNAGFGNTGIFDVGVANLGNYNI FT GFGNFGDDNLGFANLGSYNIGVANTGSNNIGFANTGSNNIGIGLTGTGQIGIGALNSGS FT GNIGLFNSGDGNIGFFNSGTGNFGIGNTGTGNFGIGNSGSTSTGLFNSGDGNTGGFNPG FT NFNTGNFNTGSFNTGGFNAGNTNTGHFNTGNYNTGIANTGDVSTGAFISGNYSNGILWR FT GDYQGLIGYSYALTIPEIPAHLDVNIPIDIPITGSFTDLVVDNFTIPIIGFESFAFSFH FT IHTEPDIGPIIVPSFVLSVPTFAIAVGGPTTAINISATAGLGPITIPIIDIPAAPGIGN FT STTSPSSGFFNTGAGTASGFGNVGGNTSGLWNLASAASGVSGLLNVGALGSGVANVGNT FT ISGIYNTSPLDLGTPAFGSGLANIAGLLQGGAGTTILDLAGLGNLNVGLANLGGSNFGI FT GNTGIFNVGFANVGNHNIGLANLGNYSVGFANSGNYHIGIANTGSANIGFANTGSGNIG FT IGLTGTGQIGFGSFNSGSHNIGLFNSGDGNVGFFNSGTGNVGIGNTGTANFGIANSGSF FT NTGLGNTGSTNTGLFNPGNVNTGVGNTGSINTGSINTGSFNTGSTNTGSFNLGDHNTGS FT FNSGDYNTGYFNAGDYNTGVANTGNVNTGAFISGNYSNGFFWRGDYQGLIGLSTTITIP FT EIPYRYDLSVPIDIPITGTVVATTPNSFTIPGFQIRVLLGPAAVLVNEMIGPITIDVNQ FT VIAIDSPIQQTISMVGTGGFGPIPIGISIGGTPGFGNSTTGPSSGFFHTGAGHVSGFGN FT FGAGNMSGSGNFGAGNSGFFNAGGLGNSGLLNFGALQSGLANLGNTISGVYNTSTLDLA FT TPAFGSGIANIGANLAGLFLDNTGNLTLNFGVANQGGLNAGIGNLGSVNIGFVNTGDSN FT LGIGNLGDLNFGGVNIGGNNIGIANTGIFDIGLANLGSYNIGLANLGDDNLGFGNAGSY FT NIGFANFGSDNLGFANTGSYNIGFANTGNNNIGVGLTGNGQIGIGSLNSGSNNIGLFNS FT GSGNIGFFNSGTGNVGIFNTGTGNFGLANSGGFNTGIGNAGSTNTGVFNPGDLNTGSFN FT PGSFNTGGFNPGSGNTGYLNTGDYNTGVANTGDVDTGAFITGSYSNGFLVSGDYQGLIG FT LPLLGIPVTPGYFNLTGGPSSGFFNSGAGSVSGFVNSGAGLSGYLNTGALGSGVANVGN FT TISGWLNASALDLATPGFLSGIGNFGTNLAGFFRG" FT CDS complement(30913..33804) FT /transl_table=11 FT /gene="PPE6" FT /locus_tag="Rv0305c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0305c, (MTCY63.10c), len: 963 aa. Member of the FT Mycobacterium tuberculosis PE family (PPE, MPTR), similar FT to others e.g. Y04H_MYCTU|Q10778 from Mycobacterium FT tuberculosis (734 aa), FASTA scores: opt: 1340, E(): 0, FT (40.9% identity in 815 aa overlap)." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q6MX48" FT /protein_id="CAE55270.1" FT /translation="MDFVVSAPEVNSLRMYLGAGSGPMLAAAAAWDGLADELAVAASWF FT GSVTSGLADAAWRGPAAVAMARAVAPYLGWLISATAQAEQAAAQARVAVATFEAARAAT FT VHPAIVAANRAVLVSLVSSNLLGFNAPAIAATEAAYERMWAQDVAAMVGYHAGASAAVS FT ALMPFTQQLKKLAGLSERLTSAAAAAAGPPSAAGFNLGLANVGANNVGNGNVGVFNVGF FT GNLGSYNLGFANLGSDNLGLANLGGHNIGFANTGSNNVGFGNTGSNNVGIGLTGNGQIG FT FGSFNSGSHNIGLFNSGSGNVGLFNSGTGNFGIGNSGTGNFGLGNTGSTNTGWFNTGDV FT NTGGFNPGSYNTGNFNTGNYNTGSFNAGNYNTGYFNTGDYNTGVANTGNVNTGAFIAGN FT YSNGVLWRGDYQGLIGADIALEIPAIPINAQLFSMPIHQVMVMPGSVMTIPGMRLPFTS FT IVPFVVYYGPVELPQSTLTLPTVTITVGGPTTTIDGNLTGMVGGVSIPLIKIPAAPGFG FT NSTTSPSSGFFNAGAGTASGFGNFGGGASGFWNLASATSGLSGFGNVGALGSGVANVGN FT TISGLYNTSTSNLATPAFNSGLLHHSVGTMTLNFGLANVGGNNVGGANAGIFNVGLANL FT GDYNIGFGNLGGDNLGFAHAGSYNIGFANTGSNNLGFANTGDNNIGFANIGSNNIGIGL FT TGSGQIGFGSLNSGSHNIGLFNSGDGNIGLFNSGSGNFGIGNAGTGNWGIGNSGAGNFG FT IGNAGSTNTGLFNSGDLNTGSLNPGSYNTGSVNTGSVNTGGFNAGNYNTGYFNTGDLQH FT RHGEHRQYQHRRFHLRQPQQRPSVAGRQPGSDRPRHRRRHSRNPDCERRREYPDSHTDH FT RQLHGHRIQRARSSTEHSRHCYFFRTRRYRPLHRPSDTDNRSHTCGHGGWTHYRDQYRR FT HCGRRRHQHPDYPYSSDSRLRQLDRRTVVGLLQ" FT CDS 34007..34678 FT /transl_table=11 FT /locus_tag="Rv0306" FT /product="PUTATIVE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0306, (MTCY63.11), len: 223 aa. Putative FT oxidoreductase (EC 1.-.-.-), highly similar to FT H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved FT hypothetical protein from Pseudomonas aeruginosa strain FT PAO1 (218 aa); and to other putative oxidoreductases e.g. FT middle part of CAB76073.1|AL157953 putative nitroreductase FT from Streptomyces coelicolor (1212 aa); Q52685|BLUB protein FT involved in cobalamin (vitamin B12) synthesis from FT Rhodobacter capsulatus (206 aa), FASTA scores: opt: 318, FT E(): 2e-15, (35.6% identity in 191 aa overlap). TBparse FT score is 0.900." FT /db_xref="GOA:O07233" FT /db_xref="InterPro:IPR000415" FT /db_xref="UniProtKB/TrEMBL:O07233" FT /protein_id="CAB09594.1" FT /translation="MFSAPERRAVYRVIAERRDMRRFVPGGVVSEDVLARLLHAAHAAP FT SVGLMQPWRFIRITDETLKRRIHALVDDERLLTAEALGAREEEFLALKVEGILDCAELL FT VVALCDRRGSYIFGRRTLPQMDLASVSCAIQNLWLAARSEGLGMGWVSLFDPQRLAALL FT AMPADAEPVAILCLGPVPEFPDRPALELDGWAYARPLAEFVSENRWSYPSALATDHHHG FT E" FT CDS complement(34666..35148) FT /transl_table=11 FT /locus_tag="Rv0307c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0307c, (MTCY63.12c), len: 160 aa. Hypothetical FT unknown protein. TBparse score is 0.901." FT /db_xref="UniProtKB/TrEMBL:O07234" FT /protein_id="CAB09580.1" FT /translation="MAVIVRKWFGLGRLPADLRCQVEAEGLIYLAEYVAVTRRFTGVIP FT GLRASHSIASYVGALAFTEQRVLGTLSMVPKLAGRVVDARWDGPQAGAATAEISPTGLQ FT LDLDVADVDPKFSGQLALHFKATIGEDVLSRLPRRSLAFDVPAEYVNLAVGVTYSP" FT CDS 35206..35922 FT /transl_table=11 FT /locus_tag="Rv0308" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0308, (MTCY63.13), len: 238 aa. Probable conserved FT integral membrane protein, with C-terminus highly similar FT to C-terminus of other integral membrane proteins or FT phosphatases e.g. FT AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1 FT putative phosphatase from Streptococcus pyogenes (201 aa); FT Q06074 HYPOTHETICAL 24.9 kDa PROTEIN (216 aa), FASTA FT scores: opt: 209, E(): 2e-07, (27.9% identity in 140 aa FT overlap). Could be a phosphatase. TBparse score is 0.961." FT /db_xref="GOA:O07235" FT /db_xref="InterPro:IPR016118" FT /db_xref="UniProtKB/TrEMBL:O07235" FT /protein_id="CAB09581.1" FT /translation="MTRPQALLAVSLAFVATAVYAVMWVGHSQDWGWLHSFDWSLLNAA FT HDIGIKNPAWVRFWDGVSLILGPVVLRPLGLLAAMVALAKRKIRIALLLLACLPLNAIM FT TIAAKSVAHRPRPATALVSAHSTSFPSGHALEATASVLALLTVLLPMLHSRFTRHIAIT FT VGALCVLTVGVARVALNVHHPTDVVAGWALGYLYFLVCLCVFRPPSIFGAQRASHALSP FT PVEVSRQPEPEVDTAR" FT CDS 36024..36680 FT /transl_table=11 FT /locus_tag="Rv0309" FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0309, (MTCY63.14), len: 218 aa. Possible conserved FT exported protein (has putative N-terminal signal sequence), FT equivalent to AC32053.1|AL583926 putative secreted protein FT from Mycobacterium leprae (218 aa). Also similar to others FT e.g. AB76092.1|AL157956 putative secreted protein from FT Streptomyces coelicolor (238 aa)." FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:O07236" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09582.1" FT /translation="MSRLLALLCAAVCTGCVAVVLAPVSLAVVNPWFANSVGNATQVVS FT VVGTGGSTAKMDVYQRTAAGWQPLKTGITTHIGSAGMAPEAKSGYPATPMGVYSLDSAF FT GTAPNPGGGLPYTQVGPNHWWSGDDNSPTFNSMQVCQKSQCPFSTADSENLQIPQYKHS FT VVMGVNKAKVPGKGSAFFFHTTDGGPTAGCVAIDDATLVQIIRWLRPGAVIAIAK" FT CDS complement(36750..37241) FT /transl_table=11 FT /locus_tag="Rv0310c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0310c, (MTCY63.15c), len: 163 aa. Conserved FT hypothetical protein, similar to some bile acid FT dehydratases e.g. FT P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 FT BILE ACID-INDUCIBLE OPERON PROTEIN E from Eubacterium sp FT (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% FT identity in 134 aa overlap); AAF22847.1|AF210152_4 bile FT acid 7a-dehydratase from Clostridium sp. (168 aa). TBparse FT score is 0.863." FT /db_xref="UniProtKB/TrEMBL:O07237" FT /protein_id="CAB09600.1" FT /translation="MCCNGVVTPGDPADIAAIKQLKYRYLRALDTKHWDDFTDTLAEDV FT TGDYGSSVGTELHFTNRADLVDYLRQALGPGVITEHRVTHPEITVTGDTATGIWYLQDR FT VIVAEFNFMLIGAAFYHDQYRRTTDGWRISATGYDRTYEATMSLAGLNFNIRPGRALAD FT " FT CDS 37265..38494 FT /transl_table=11 FT /locus_tag="Rv0311" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0311, (MTCY63.16), len: 409 aa. Hypothetical FT unknown protein. Contains PS00881 Protein splicing FT signature. TBparse score is 0.903." FT /db_xref="InterPro:IPR018254" FT /db_xref="UniProtKB/TrEMBL:O07238" FT /protein_id="CAB09583.1" FT /translation="MSQSRYAGLSRSELAVLLPELLLIGQLIDRSGMAWCIQAFGRQEM FT LQIAIEEWAGASPIYTKRMQKALNFEGDDVPTIFKGLQLDIGAPPQFMDFRFTLHDRWH FT GEFHLDHCGALLDVEPMGDDYVVGMCHTIEDPTFDATAIATNPRAQVRPIHRPPRKPAD FT RHPHCAWTVIIDESYPEAEGIPALDAVRETKAATWELDNVDASDDGLVDYSGPLVSDLD FT FGAFSHSALVRMADEVCLQMHLLNLSFAIAVRKRAKADAQLAISVNTRQLIGVAGLGAE FT RIHRAMALPGGIEGALGVLELHPLLNPAGYVLAETSPDRLVVHNSPAHADGAWISLCTP FT ASVQPLQAIATAVDPHLKVRISGTDTDWTAELIEADAPASELPEVLVAKVSRGSVFQFE FT PRRSLPLTVK" FT misc_feature 38225..38242 FT /note="PS00881 Protein splicing signature" FT CDS 38649..40511 FT /transl_table=11 FT /locus_tag="Rv0312" FT /product="CONSERVED HYPOTHETICAL PROLINE AND THREONINE RICH FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv0312, (MTCY63.17), len: 620 aa. Conserved FT hypothetical protein with highly Pro-, Thr-rich C-terminus. FT Similar to Pro-,Thr-rich region in FT Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculosis FT (592 aa), FASTA scores: opt: 1075, E(): 0, (38.9% identity FT in 627 aa overlap). Also some similarity with Rv0350|dnaK FT from Mycobacterium tuberculosis. Possibly membrane protein; FT has hydrophobic stetch in its middle part." FT /db_xref="GOA:O07239" FT /db_xref="InterPro:IPR018181" FT /db_xref="UniProtKB/TrEMBL:O07239" FT /protein_id="CAB09584.1" FT /translation="MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPSQ FT NPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSEIA FT IAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGSVVGL FT LDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDV FT DPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDLIQDPL FT TGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQPGCAAA FT MGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDRELAWSQT FT DFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSAVVAMTAIG FT GVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAPLPSAAPAPT FT TVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTEPPVTTTSTIPTIPT FT TTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG" FT CDS 40583..40969 FT /transl_table=11 FT /locus_tag="Rv0313" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0313, (MTCY63.18), len: 128 aa. Conserved FT hypothetical protein, equivalent only to FT CAC32049.1|AL583926 conserved hypothetical protein from FT Mycobacterium leprae (130 aa). TBparse score is 0.877." FT /db_xref="UniProtKB/TrEMBL:O07240" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09601.1" FT /translation="MGDYGPFGFDPDEFDRVIREGSEGLRDAFERIGRFLSSSGAGTGW FT SAIFEDLSRRSRPAPETAGEAGDGVWAIYTVDADGGARVEQVYATELDALRANKDNTDP FT KRKVRFLPYGIAVSVLDDPVDEAQ" FT CDS complement(40972..41634) FT /transl_table=11 FT /locus_tag="Rv0314c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0314c, (MTCY63.19c), len: 220 aa. Possible FT conserved membrane protein, with hydrophobic stretch from FT residues ~75-100. Similar in C-terminal part to FT Mycobacterium tuberculosis proteins Rv0679c and Rv0680c." FT /db_xref="UniProtKB/TrEMBL:O07241" FT /protein_id="CAB09585.1" FT /translation="MIVVWEHLCMNPEDDPEARIRELERPLADVARASELGGSQSGGYT FT YPPGPPPPPYSYGGPFGGPSPRSSSGNRAWWILAAVVVVGVLVLVGGIAAFSAQRLSQG FT NFVVLSPTPSVSRAVPTPTAQPATTLPPAGASLSVSGVNVNRTIACNDSIVSVSGMSNT FT VVITGHCTSLTVSGMRNSVTVDSVDTIEAAGFNNEVTYHSGSPKISNAGGSNSVQQG" FT CDS 41695..42579 FT /transl_table=11 FT /locus_tag="Rv0315" FT /product="POSSIBLE BETA-1,3-GLUCANASE PRECURSOR" FT /function="POSSIBLY HYDROLYZES SPECIFIC SUGAR FT (HYDROLYZATION OF GLYCOSIDIC BOND) AND COULD BE INVOLVED IN FT EXOPOLYSACCHARIDE BIOSYNTHESIS/DEGRADATION. COULD ALSO HAVE FT A LYTIC ACTIVITY AGAINST CELL WALLS." FT /EC_number="3.2.1.-" FT /note="Rv0315, (MTCY63.20), len: 294 aa. Possible FT beta-1,3-glucanase precursor (EC 3.2.1.-) (has hydrophobic FT stretch in its N-terminal part), similar to others e.g. FT Q51333|AAC44371.1 BETA-1,3-GLUCANASE II A from Oerskovia FT xanthineolytica (306 aa), FASTA scores: opt: 76, E(): FT 3e-14, (34.1% identity in 302 aa overlap); and FT AAC38290.1|AF052745 beta-1,3-glucanase II from Oerskovia FT xanthineolytica (435 aa). Contains glycosyl hydrolases FT family 16 active site signature (PS01034). TBparse score is FT 0.908." FT /db_xref="GOA:O07242" FT /db_xref="InterPro:IPR013320" FT /db_xref="UniProtKB/TrEMBL:O07242" FT /protein_id="CAB09586.1" FT /translation="MLMPEMDRRRMMMMAGFGALAAALPAPTAWADPSRPAAPAGPTPA FT PAAPAAATGGLLFHDEFDGPAGSVPDPSKWQVSNHRTPIKNPVGFDRPQFFGQYRDSRQ FT NVFLDGNSNLVLRATREGNRYFGGLVHGLWRGGIGTTWEARIKFNCLAPGMWPAWWLSN FT DDPGRSGEIDLIEWYGNGTWPSGTTVHANPDGTAFETCPIGVDGGWHNWRVTWNPSGMY FT FWLDYADGIEPYFSVPATGIEDLNEPIREWPFNDPGYKVFPVLNLAVGGSGGGDPATGS FT YPQEMLVDWVRVF" FT misc_feature 42205..42240 FT /note="PS01034 Glycosyl hydrolases family 16 active sites" FT CDS 42628..43242 FT /transl_table=11 FT /locus_tag="Rv0316" FT /product="POSSIBLE MUCONOLACTONE ISOMERASE" FT /function="COULD BE INVOLVED IN THE CATABOLISM OF CATECHOL FT TO SUCCINATE- AND ACETYL-CoA IN THE BETA-KETOADIPATE FT PATHWAY (AT THE THIRD STEP) [CATALYTIC ACTIVITY: FT 2,5-dihydro-5-oxofuran-2-acetate = FT 3,4-dihydro-5-oxofuran-2-acetate]." FT /EC_number="5.3.3.-" FT /note="Rv0316, (MTCY63.21), len: 204 aa. Possible FT muconolactone isomerase (EC 5.3.3.-), showing weak FT similarity with some muconolactone isomerases e.g. FT O33947|CTC1_ACILW MUCONOLACTONE DELTA-ISOMERASE 1 (MIASE FT 1)(96 aa), FASTA scores: opt: 179, E(): 3.9e-05, (32.6% FT identity in 92 aa overlap). TBparse score is 0.882." FT /db_xref="GOA:O07243" FT /db_xref="InterPro:IPR003464" FT /db_xref="UniProtKB/TrEMBL:O07243" FT /protein_id="CAB09587.1" FT /translation="MEFLVTMTTRVPDSMPADAVERVRAREAARSRELAAQGKLLRLWR FT PPLRPGEWRTLGLFAADDNGELEQLLASMPPRSWRTDDVTPLGAHPNDPVGQGITIAPG FT KGPEFLIATTIMVPPGTPAQVVDDTVAREARRAPELAGRGHLVRLWALPDGPDGQRTLG FT LWRARDPGELMAILESLPLAGWMTIETTPLSPHPDDPIRMP" FT CDS complement(43266..44036) FT /transl_table=11 FT /gene="glpQ2" FT /locus_tag="Rv0317c" FT /product="POSSIBLE GLYCEROPHOSPHORYL DIESTER FT PHOSPHODIESTERASE GLPQ2 (GLYCEROPHOSPHODIESTER FT PHOSPHODIESTERASE)" FT /function="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE FT HYDROLYZES DEACYLATED PHOSPHOLIPIDS TO G3P AND THE FT CORRESPONDING ALCOHOLS [CATALYTIC ACTIVITY: A FT GLYCEROPHOSPHODIESTER + H(2)O = AN ALCOHOL + SN-GLYCEROL FT 3-PHOSPHATE]." FT /EC_number="3.1.4.46" FT /note="Rv0317c, (MTCY63.22c), len: 256 aa (start uncertain, FT chosen by homology). Possible glpQ2, glycerophosphoryl FT diester phosphodiesterase (EC 3.1.4.46), similar to others FT e.g. E75317|6459876|AAF11631.1|AE002044_4 glycerophosphoryl FT diester phosphodiesterase from Deinococcus radiodurans (285 FT aa); P10908|UGPQ_ECOLI from Escherichia coli (247 aa), FT FASTA scores: opt: 220, E(): 5.2e-07, (28.0% identity in FT 250 aa overlap). Also similar to MTCY01A6.27 from FT Mycobacterium tuberculosis FASTA score: (27.5% identity in FT 247 aa overlap). TBparse score is 0.906." FT /db_xref="GOA:O07244" FT /db_xref="InterPro:IPR004129" FT /db_xref="UniProtKB/TrEMBL:O07244" FT /protein_id="CAB09602.1" FT /translation="MEFLRHGGRIAMAHRGFTSFRLPMNSMGAFQEAAKLGFRYIETDV FT RATRDGVAVILHDRRLAPGVGLSGAVDRLDWRDVRKAQLGAGQSIPTLEDLLTALPDMR FT VNIDIKAASAIEPTVNVIERCNAHNRVLIGSFSERRRRRALRLLTKRVASSAGTGALLA FT WLTARPLGSRAYAWRMMRDIDCVQLPSRLGGVPVITPARVRGFHAAGRQVHAWTVDEPD FT VMHTLLDMDVDGIITDRADLLRDVLIARGEWDGA" FT tRNA complement(44297..44367) FT /gene="tRNA-Gly(CCC)" FT /product="transfer RNA-Gly(CCC)" FT /anticodon=(pos:44333..44335,aa:Gly) FT CDS complement(44398..45192) FT /transl_table=11 FT /locus_tag="Rv0318c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0318c, (MTCY63.23c), len: 258 aa. Probable FT conserved integral membrane protein, with some similarity FT to C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores: FT opt: 157, E (): 0.0032, (28.3% identity in 198 aa overlap). FT Also similar to O26573 CONSERVED PROTEIN from FT Methanobacterium thermoauto (259 aa), FASTA scores: opt: FT 173, E(): 5.2e-05, (32.7% identity in 214 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q6MX47" FT /protein_id="CAE55271.1" FT /translation="MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILGG FT VVPSVRTPSAAMVSGVQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLVAL FT RRFDGHGEHQDGDDVGELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALTVEV FT LFLGLAVALRLAGSGMPRIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVLAFAA FT GALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYGLGVME" FT CDS 45241..45909 FT /transl_table=11 FT /gene="pcp" FT /locus_tag="Rv0319" FT /product="PROBABLE PYRROLIDONE-CARBOXYLATE PEPTIDASE PCP FT (5-OXOPROLYL-PEPTIDASE) (PYROGLUTAMYL-PEPTIDASE I) (PGP-I) FT (PYRASE)" FT /function="REMOVES 5-OXOPROLINE FROM VARIOUS PENULTIMATE FT AMINO ACID RESIDUES EXCEPT L-PROLINE [CATALYTIC ACTIVITY: FT 5-oxoprolyl-peptide + H2O = 5-oxoproline + peptide]." FT /EC_number="3.4.19.3" FT /note="Rv0319, (MTCY63.24), len: 222 aa. Probable pcp, FT pyrrolidone-carboxylate peptidase (EC 3.4.19.3), highly FT similar to others e.g. PCP_PSEFL|P42673 FT pyrrolidone-carboxylate peptidase from Pseudomonas FT fluorescens (213 aa), FASTA scores: opt: 478, E(): 7.5e-25, FT (40.2% identity in 219 aa overlap). BELONGS TO PEPTIDASE FT FAMILY C15 (THIOL PROTEASE). TBparse score is 0.902." FT /db_xref="GOA:P0A5R4" FT /db_xref="HSSP:1IU8" FT /db_xref="InterPro:IPR016125" FT /db_xref="UniProtKB/Swiss-Prot:P0A5R4" FT /protein_id="CAB09588.1" FT /translation="MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNT FT FFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVLVG FT EPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQKGLP FT VRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI FT " FT CDS 45981..46643 FT /transl_table=11 FT /locus_tag="Rv0320" FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0320, (MTCY63.25), len: 220 aa. Possible conserved FT exported protein, similar to some hypothetical proteins and FT to the middle part of a peptidase: FT NP_066789.1|10657900|AAG21739.1|AF116907 putative peptidase FT from Rhodococcus equi (546 aa). Also similar to FT Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256 FT aa), FASTA scores: opt: 497, E(): 1.2e-26, (41.8% identity FT in 225 aa overlap). TBparse score is 0.943." FT /db_xref="UniProtKB/TrEMBL:O07246" FT /protein_id="CAB09604.1" FT /translation="MGRHELARDRRKSSAVLAAVLAPAAVFFATGGDVSTLAARADANP FT VLGDDAPCCVQIVPVAPLAFSSQISGGEIGTGLAASQFASASRWRIVSRYLPVGVAPEQ FT GLQVKTVLTARSISAAFPEIREIGGVRPDALRWHPNGLALDVMVPNPGTAEGIALGNEI FT VAFVLKNATRFGMQDVIWRGAYYTPNGARTTGAGHYDHIHITTVGGGYPTGEELYIR" FT CDS 46675..47247 FT /transl_table=11 FT /gene="dcd" FT /locus_tag="Rv0321" FT /standard_name="dus; paxA" FT /product="PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD FT (DCTP DEAMINASE)" FT /function="INVOLVED IN INTERCONVERSION OF dCTP AND dUTP FT [CATALYTIC ACTIVITY: dCTP + H2O = dUTP + NH3]." FT /EC_number="3.5.4.13" FT /note="Rv0321, (MTCY63.26), len: 190 aa. Probable dcd FT (alternate gene names: dus or paxA), deoxycytidine FT triphosphate deaminase (EC 3.5.4.13), equivalent to FT CAC32024.1|AL583925 probable deoxycytidine triphosphate FT deaminase from Mycobacterium leprae (190 aa). Also highly FT similar to others e.g. FT Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46 DEOXYCYTIDINE FT TRIPHOSPHATE DEAMINASE from Streptomyces coelicolor (191 FT aa); DCD_ECOLI|P28248|DUS|PAXA|B2065 DEOXYCYTIDINE FT TRIPHOSPHATE DEAMINASE from Escherichia coli strain K12 FT (193 aa), FASTA scores: opt: 408, E(): 2.7e-21, (43.1% FT identity in 188 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE DCTP FT DEAMINASE FAMILY. TBparse score is 0.907. The transcription FT of this CDS seems to be activated specifically in host FT granulomas (see citation below)." FT /db_xref="GOA:O07247" FT /db_xref="InterPro:IPR008180" FT /db_xref="PDB:2QLP" FT /db_xref="UniProtKB/Swiss-Prot:O07247" FT /protein_id="CAB09605.1" FT /translation="MLLSDRDLRAEISSGRLGIDPFDDTLVQPSSIDVRLDCLFRVFNN FT TRYTHIDPAKQQDELTSLVQPVDGEPFVLHPGEFVLGSTLELFTLPDNLAGRLEGKSSL FT GRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCMLRLTSPSEHPYG FT SSRAGSKYQGQRGPTPSRSYQNFIRST" FT misc_feature 46957..46980 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 47353..48684 FT /transl_table=11 FT /gene="udgA" FT /locus_tag="Rv0322" FT /standard_name="rkpK" FT /product="PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA FT (UDP-GLC DEHYDROGENASE) (UDP-GLCDH) (UDPGDH)" FT /function="POSSIBLY INVOLVED IN POLYSACCHARIDE BIOSYNTHESIS FT [CATALYTIC ACTIVITY: UDP-glucose + 2 NAD+ + H2O = FT UDP-glucuronate + 2 NADH]." FT /EC_number="1.1.1.22" FT /note="Rv0322, (MTCY63.27), len: 443 aa. Probable udg FT (alternate gene name: rkpK), UDP-glucose 6-dehydrogenase FT (EC 1.1.1.22), highly similar to others e.g. FT CAC44517.1|AL596138 putative UDP-glucose 6-dehydrogenase FT from Streptomyces coelicolor (447 aa); Q56812 UDP-GLUCOSE FT DEHYDROGENASE from Xanthomonas campestris (445 aa), FASTA FT scores: opt: 713, E(): 0, (41.9% identity in 351 aa FT overlap); etc. Also similar to several GDP-mannose FT 6-dehydrogenase. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). BELONGS TO THE UDP-GLUCOSE/GDP-MANNOSE FT DEHYDROGENASES FAMILY. TBparse score is 0.905." FT /db_xref="GOA:O07248" FT /db_xref="HSSP:1MFZ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O07248" FT /protein_id="CAB09606.1" FT /translation="MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIP FT FYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHAVI FT DALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAVHDT FT LNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKIS FT FINAISEVCEAAGADVSQLADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGEL FT GADQALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPA FT LNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFID FT LEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH" FT misc_feature 47692..47715 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(48673..49344) FT /transl_table=11 FT /locus_tag="Rv0323c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0323c, (MTCY63.28c), len: 223 aa. Conserved FT hypothetical protein, similar to others e.g. FT YPJG_BACSU|P42981 hypothetical 24.8 kDa protein from FT Bacillus subtilis (224 aa), FASTA scores: opt: 182, E(): FT 1.3e-05, (27.5% identity in 211 aa overlap). Also some FT similarity to MLU15183_8 from Mycobacterium tuberculosis FT FASTA score: (32.0% identity in 147 aa overlap). TBparse FT score is 0.932." FT /db_xref="HSSP:1UAN" FT /db_xref="InterPro:IPR003737" FT /db_xref="UniProtKB/TrEMBL:O07249" FT /protein_id="CAB09612.1" FT /translation="MNSCNRLPCAHEVLAVFAHPDDESFGLGAVLGDFTAQGTRLRGLC FT FTHGEASTLGRTDRNLGEVRREELAAAAQVLGVDHVQLLAYPDNGLAQIPLNELTQRVV FT DALAGADLLLVFDDNGVTGHPDHRRATEAALAAASTPSIPVLAWALPQPIADRLNAEFS FT ASFGGRGHGHLDIMIEVDRSRQLAAIGCHFTQSADNPVLWRRLELLGDREYLRWLRRSV FT P" FT CDS 49445..50125 FT /transl_table=11 FT /locus_tag="Rv0324" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY ARSR-FAMILY)" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0324, (MTCY63.29), len: 226 aa. Possible FT transcriptional regulator, arsR family, with its N-terminus FT similar to the N-terminus of other DNA-binding proteins FT e.g. P30346|MERR_STRLI probable mercury resistance operon FT from Streptomyces lividans (125 aa), FASTA scores: opt: FT 154, E(): 0.002, (32.2% identity in 90 aa overlap)), and FT its C-terminal part similar to hypothetical bacterial FT proteins e.g. P54510|YQHL_BACSU hypothetical 14.6 kDa FT protein from Bacillus subtilis (126 aa), FASTA scores: opt: FT 159, E(): 0.00097, (35.5% identity in 76 aa overlap)). Most FT similar to AJ005575|SPE005575_2 ORF1 required for FT antibiotic production from Streptomyces peucetius (226 aa), FT FASTA scores: opt: 816, E(): 0, (60.7% identity in 211 aa FT overlap). Also similar in C-terminus to MTCY164.26 FT molybdopterin biosynthesis moeb protein from Mycobacterium FT tuberculosis FASTA score: (36.8% identity in 114 aa FT overlap)." FT /db_xref="GOA:O08446" FT /db_xref="HSSP:1URH" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:O08446" FT /protein_id="CAB09589.1" FT /translation="MAGQSDRKAALLDQVARVGKALANGRRLQILDLLAQGERAVEAIA FT TATGMNLTTASANLQALKSGGLVEARREGTRQYYRIAGEDVARLFALVQVVADEHLADV FT AVAAADVLGSPEDAITRAELLRRREAGEVTLVDVRPHEEYQAGHIPGAINIPIAELADR FT LAELTGDRDIVAYCRGAYCVMAPDAVRIARDAGREVKRLDDGMLEWRLAGLPVDEGAPV FT GHGD" FT CDS 50132..50356 FT /transl_table=11 FT /locus_tag="Rv0325" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0325, (MTCY63.30), len: 74 aa. Hypothetical FT unknown protein. TBparse score is 0.915." FT /db_xref="UniProtKB/TrEMBL:O07250" FT /protein_id="CAB09607.1" FT /translation="MGPKGSLRLVKRQPELLVAQHEHWQDTYRAHPVLYGTRPSEPGVY FT AAEVFNADGVQRVLELAAGHGRDTLYFAG" FT CDS 50366..50821 FT /transl_table=11 FT /locus_tag="Rv0326" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0326, (MTCY63.31), len: 151 aa. Hypothetical FT unknown protein. TBparse score is 0.929." FT /db_xref="GOA:O07251" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:O07251" FT /protein_id="CAB09608.1" FT /translation="MVATDFSDVAVAQLRRSAQARGVSARVQPIVHDLRQPLPVKTGSI FT DGAFAHMALCMALSTSEIHAVVAEVGRVLRPGGKFIYTVRHTGDAHYGAGQAHGDDIFE FT CAGFAVHFFRRELVARLATGWVLEEVHDFEEGELPRRLWRVTVTKPA" FT CDS complement(50789..52138) FT /transl_table=11 FT /gene="cyp135A1" FT /locus_tag="Rv0327c" FT /product="POSSIBLE CYTOCHROME P450 135A1 CYP135A1" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv0327c, (MT0342, MTCY63.32c), len: 449 aa. Possible FT cyp135A1, cytochrome P450 (EC 1.14.-.-), similar to FT cytochrome P-450 monoxygenases and other cytochrome P-450 FT related enzymes e.g. FQ12609 PUTATIVE P450 MONOOXYGENASE FT (EC 1.14.14.1) (506 aa), FASTA scores: opt: 276, E() : FT 1.7e-11, (27.9% identity in 433 aa overlap). Also similar FT to other Mycobacterium tuberculosis proteins e.g. FT MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa); FT MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in FT 434 aa overlap). Contains cytochrome P450 cysteine FT heme-iron ligand signature (PS00086). BELONGS TO THE FT CYTOCHROME P450 FAMILY. Alternative start possible at 33706 FT but no RBS." FT /db_xref="GOA:O08447" FT /db_xref="HSSP:1JME" FT /db_xref="InterPro:IPR002401" FT /db_xref="UniProtKB/Swiss-Prot:O08447" FT /protein_id="CAB09576.1" FT /translation="MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFSL FT RVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHARMR FT SLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTD FT PKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIASRRI FT DSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLWELAHA FT PEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPAGTVVNT FT SILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTEGAVILQE FT IFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP" FT misc_feature complement(50984..51013) FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand si FT gnature" FT CDS 52204..52806 FT /transl_table=11 FT /locus_tag="Rv0328" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR/ACRR-FAMILY)" FT /function="POSSIBLY INVOLVED IN A TRANSCRIPTIONAL FT MECHANISM." FT /note="Rv0328, (MTCY63.33), len: 200 aa. Possible FT transcription regulator, tetR/acrR family, similar in part FT to various hypothetical transcriptional regulators e.g. FT T36696|4726006|CAB41735.1|AL049731 probable regulatory FT protein from Streptomyces coelicolor (197 aa). Also some FT similarity with YX44_MYCTU|Q10829 hypothetical FT transcriptional regulator from Mycobacterium tuberculosis FT (195 aa), FASTA scores: opt: 154, E(): 0.00061, (26.7% FT identity in 202 aa overlap). Contains probable helix-turn FT helix motif from aa 27-48 (Score 1408, +3.98 SD). SEEMS TO FT BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL FT REGULATORS. TBparse score is 0.910." FT /db_xref="GOA:O07252" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:O07252" FT /protein_id="CAB09609.1" FT /translation="MQQQRTNRDKLLDGALACLRERGYGNTSSRDIARAAGVNIASINY FT HFGSKDALLDDALGRCFSTWNQRVQEAFDHSRAAGPAGQILAVLEATVDSFEQIRPAVY FT ACVESYAPALRSEALRERLAAGYADVRQHSVDLAGAALAGTDIAPPENLSTIVSVLMAV FT IDGLMIQWIADPSATPRSTEVIRALASIGAVVTSQLR" FT CDS complement(52787..53413) FT /transl_table=11 FT /locus_tag="Rv0329c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0329c, (MTCY63.34c), len: 208 aa. Conserved FT hypothetical protein, showing some similarity with others FT hypothetical proteins and methyltransferases e.g. FT MitM|AF127374_14 methyltransferase from Streptomyces FT lavendulae (283 aa), FASTA scores: opt: 242, E(): 1.8e-08, FT (37.2% identity in 145 aa overlap); Q48938 from FT Methanosarcina barkeri (262 aa), FASTA scores: opt: 194, FT E(): 3.6e-06, (31.1% identity in 119 aa overlap). TBparse FT score is 0.923." FT /db_xref="GOA:O07253" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:O07253" FT /protein_id="CAB09577.1" FT /translation="MRLTHPARRYLSSQAARPTGAFGRLLGRIWRAETADVNRIAVELL FT APGPGERVCEIGFGPGRTLGLLAAAGAQVSGVEVSTTMIAIAAHHNAKAIAAGLISLYH FT GDGVTLPVADHSLDKVLGVHNFYFWPDPRASLCDIARALRPGGRLVLTSISDDQPLAAR FT FDPAIYRVPPTLDTAAWLGAAGFIDVGIKRSADHPATVWFTATAT" FT CDS complement(53440..54180) FT /transl_table=11 FT /locus_tag="Rv0330c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0330c, (MTCY63.35c), len: 246 aa. Hypothetical FT unknown protein. TBparse score is 0.898." FT /db_xref="GOA:O07254" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:O07254" FT /protein_id="CAB09578.1" FT /translation="MARSIPADRFSAIVAASARVFIAHGYQRTQVQDVADALALAKGTL FT YGYAQGKAALFAAAVRYGDAQEALPLASELPVAAPVAGEIAAVVSARLAGEVTDMRLTH FT ALRATLPPGATTGDARAELAGIVTDLYSRLARHRIALKLVDRCAPELPDLAEVWFGTGR FT NAQVDAVQAYLVHRERAGLLILPGPAPMVARTIVELCALWAVHLHFDPSPEPWSIVQPG FT VIDDDAIAATLAEFVVRATTASSD" FT CDS 54294..55460 FT /transl_table=11 FT /locus_tag="Rv0331" FT /product="POSSIBLE DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0331, (MTCY63.36), len: 388 aa. Possible FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT dehydrogenases/reductases e.g. FT NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein FT reductase from Mesorhizobium loti (377 aa); NP_147681.1 FT predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum FT pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase FT (431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6% FT identity in 348 aa overlap). TBparse score is 0.906." FT /db_xref="GOA:O07255" FT /db_xref="InterPro:IPR015904" FT /db_xref="UniProtKB/TrEMBL:O07255" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09579.1" FT /translation="MSKTVLILGAGVGGLTTADTLRQLLPPEDRIILVDRSFDGTLGLS FT LLWVLRGWRRPDDVRVRPTAASLPGVEMVTATVAHIDIAAQVVHTDNSVIGYDALVIAL FT GAALNTDAVPGLSDALDADVAGQFYTLDGAAELRAKVEALEHGRIAVAIAGVPFKCPAA FT PFEAAFLIAAQLGDRYATGTVQIDTFTPDPLPMPVAGPEVGEALVSMLKDHGVGFHPRK FT ALARVDEAARTMHFGDGTSEPFDLLAVVPPHVPSAAARSAGLSESGWIPVDPRTLSTSA FT DNVWAIGDATVLTLPNGKPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTGTGACYV FT ETGDHQAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT" FT CDS 55535..56320 FT /transl_table=11 FT /locus_tag="Rv0332" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0332, (MTCY63.37), len: 261 aa. Conserved FT hypothetical protein, similar to several conserved FT hypothetical proteins from Streptomyces coelicolor e.g. FT SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein FT (266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7% FT identity in 251 aa overlap). TBparse score is 0.905." FT /db_xref="InterPro:IPR010872" FT /db_xref="UniProtKB/TrEMBL:O07256" FT /protein_id="CAB09610.1" FT /translation="MRKPASSLAKVDYSSAYLEQTHAFGELIRNVDQSTPVPTCPGWSL FT GQLFRHVGRGDRWAAQIVRDRLDHFLDPRSVEGGKPPPDPDDAISWLYGGARLLVDAVE FT QTGVETPVWTFLGPRPAGWWVRRRLHEVAVHRADVAITVGGEFTLEPNVAADGISEFLE FT RIAVQAGSGGTPLPLEDDDTLHLHATDPGLLEAGEWTVRRDERGVTWSHRHGKGAVALR FT GGATELLLAMVRRLSVADTGIELLGDAGVWQKWLDRTPL" FT CDS 56347..56721 FT /transl_table=11 FT /locus_tag="Rv0333" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0333, (MTCY63.38), len: 124 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O33273" FT /protein_id="CAB09595.1" FT /translation="MTTSEIATVLAWHDALNAADIETLVALSTDDIDIGDAHGAVQGHD FT ALRGWASSLTTTAELGRMYVHHGVVVVEQKITSGEDPGIARTGAAAFRVVQDHVASVFR FT HEDLASALAATELTEDDLVD" FT CDS 56751..57617 FT /transl_table=11 FT /gene="rmlA" FT /locus_tag="Rv0334" FT /standard_name="rfbA" FT /product="ALPHA-D-GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE FT RMLA (DTDP-GLUCOSE SYNTHASE) (DTDP-GLUCOSE FT PYROPHOSPHORYLASE)" FT /function="DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O FT ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE FT BIOSYNTHESIS [CATALYTIC ACTIVITY: dTTP + alpha-D-glucose FT 1-phosphate = diphosphate + dTDP-glucose]." FT /EC_number="2.7.7.24" FT /note="Rv0334, (MTCY279.01), len: 288 aa. rmlA (alternate FT gene name: rfbA), alpha-D-glucose-1-phosphate FT thymidylyl-transferase (EC 2.7.7.24) (see citations below), FT equivalent to CAC32020.1|AL583925 glucose-1-phosphate FT thymidyltransferase from Mycobacterium leprae (288 aa). FT Also highly similar to others e.g. AAG29804.1|AF235050 FT glucose-1-phosphate thymidylyltransferase from Streptomyces FT rishiriensis (296 aa); RBA1_ECOLI|P37744 FT glucose-1-phosphate thymidylyltransferase from Escherichia FT coli strain K12 (293 aa), FASTA scores: opt: 1199, E(): 0, FT (62.0% identity in 284 aa overlap). BELONGS TO THE FT GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE FAMILY." FT /db_xref="GOA:P72017" FT /db_xref="HSSP:1FXO" FT /db_xref="InterPro:IPR005907" FT /db_xref="UniProtKB/TrEMBL:P72017" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09613.1" FT /translation="MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAG FT IRDIQLITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGADSVAL FT VLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAEGMALSLEEKPVTP FT KSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVNQVYLNQGRLAVEVLARGTAWLD FT TGTFDSLLDAADFVRTLERRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSGYGNYL FT LELLERN" FT CDS complement(57628..58143) FT /transl_table=11 FT /gene="PE6" FT /locus_tag="Rv0335c" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0335c, (MTCY279.02c), len: 171 aa. Member of the FT Mycobacterium tuberculosis PE family (see Brennan & Delogu FT 2002); contains short region of similarity to part of the FT unique N-terminus of the Mycobacterium tuberculosis PGRS FT family of Glycine-rich proteins e.g. Y03A_MYCTU|Q10637 FT hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA FT scores: opt: 219, E(): 1.1e-08, (51.5% identity in 66 aa FT overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:O86338" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55272.1" FT /translation="MRSMGFLHRACRAPSSLPAPLMARPGRSVLARPAATPPGPLCATT FT RPRPPQGNQPPASRISNFPPKRHKTRVLAAAEDEVSAAVAALISAHGRRHHSLNNQAAA FT FHGQFAQNLNVGAGSCASAETTADAPTQALLGPADRQRRQRRAVRQWLVRWAAHPGRAT FT RGFHNHRQ" FT CDS 58285..59796 FT /transl_table=11 FT /locus_tag="Rv0336" FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT /function="UNKNOWN. THOUGHT TO BE REGULATED BY FT Rv2720|LEXA." FT /note="Rv0336, (MTCY279.03), len: 503 aa. Part of FT Mycobacterium tuberculosis 13E12 repeat family; almost FT identical to Rv0515|MTCY20G10.05 hypothetical protein from FT Mycobacterium tuberculosis FASTA scores: (99.8% identity in FT 503 aa overlap), possibly due to a recent gene duplication. FT Also similar to other Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv1148c, Rv1945, etc." FT /db_xref="GOA:O33266" FT /db_xref="InterPro:IPR003870" FT /db_xref="UniProtKB/TrEMBL:O33266" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB10791.1" FT /translation="MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAA FT QLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERL FT PKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQV FT DKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTV FT CEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATING FT TGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDL FT TCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTL FT ILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQD FT RAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDPNDDPPPF" FT CDS complement(59966..61255) FT /transl_table=11 FT /gene="aspC" FT /locus_tag="Rv0337c" FT /product="PROBABLE ASPARTATE AMINOTRANSFERASE ASPC FT (TRANSAMINASE A) (ASPAT)" FT /function="GENERATES OXALOACETATE AND L-GLUTAMATE FROM FT L-ASPARTATE AND 2-OXOGLUTARATE [CATALYTIC ACTIVITY: FT L-ASPARTATE + 2-OXOGLUTARATE = OXALOACETATE + FT L-GLUTAMATE]." FT /EC_number="2.6.1.1" FT /note="Rv0337c, (MTCY279.04c), len: 429 aa. Probable aspC, FT aspartate aminotransferase (transaminase A) (EC 2.6.1.1), FT equivalent to CAC32019.1|AL583925 probable aspartate FT aminotransferase from Mycobacterium leprae (437 aa). Also FT highly similar to many e.g. Q48143|U32823 aspartate FT aminotransferase (404 aa), FASTA scores: opt: 1646, E(): 0, FT (57.2% identity in 404 aa overlap). Also some similarity to FT Rv3565|MTCY06G11.12 from Mycobacterium tuberculosis FASTA FT score: (27.2% identity in 383 aa overlap). BELONGS TO FT CLASS-I OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. FT COFACTOR: PYRIDOXAL PHOSPHATE." FT /db_xref="GOA:P63498" FT /db_xref="HSSP:1BKG" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P63498" FT /protein_id="CAB10792.1" FT /translation="MDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGPV FT HQHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSARRA FT VVTRYELVPGFPRFDVDDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTASTSL FT AGGTPVHYLCDETQGWQPDIADLESKITERTKALVVINPNNPTGAVYSCEILTQMVDLA FT RKHQLLLLADEIYDKILYDDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGWLAITG FT PKEHASSFIEGIGLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQRDIAWT FT KLNEIPGVSCVKPAGALYAFPRLDPEVYDIDDDEQLVLDLLLSEKILVTQGTGFNWPAP FT DHLRLVTLPWSRDLAAAIERLGNFLVSYRQ" FT CDS complement(61286..63934) FT /transl_table=11 FT /locus_tag="Rv0338c" FT /product="PROBABLE IRON-SULFUR-BINDING REDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0338c, (MTCY279.05c), len: 882 aa. Probable FT iron-sulphur-binding reductase (EC 1.-.-.-), possibly FT membrane-bound, equivalent to CAC32018.1|AL583925 probable FT iron-sulphur-binding reductase from Mycobacterium leprae FT (880 aa). Also highly similar to others e.g. FT T36608|5019323|CAB44376.1|AL078610 probable FT iron-sulfur-binding reductase from Streptomyces coelicolor FT (760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity FT in 772 aa overlap); BAB07521.1|AP001520 FT iron-sulphur-binding reductase from Bacillus halodurans FT (700 aa). Contains PS00070 Aldehyde dehydrogenases cysteine FT active site and two of PS00198 4Fe-4S ferredoxins, FT iron-sulfur binding region signature. First of several FT possible start sites chosen." FT /db_xref="GOA:O33268" FT /db_xref="InterPro:IPR012285" FT /db_xref="UniProtKB/TrEMBL:O33268" FT /protein_id="CAB10793.1" FT /translation="MTTQTLIRLILGMSMTAVVGVFALRRVWWLYKLVMSGQPASGRTD FT NLGTRIWTQISEVLGQRRLLKWSIPGLAHFFTMWGFFILLTVYIEAYGLLFEERFHIPV FT IGRWDALGFLQDFFATAVFLGITTFAIIRILRNPREIGRSSRFYGSHNGGAWLVLLMIF FT NVIWTYVLVRGSAVNNGTLPYGNGAFLSQLFGAILRPLGQPANEIIETTALLLHIGVML FT AFLILVLHSKHLHIFLAPINVTFKRLPDGLGPLLPLEADGKPIDFENPSEDAVFGRGKI FT EDFTWKGMLDFATCTECGRCQSQCPAWNTGKPLSPKLVIMDLRDHWMAKAPYILGQKDA FT SAGGEAGHQEHHHVPESGFGRVPGHGPEQATRPLVGTEEQGGVIDPDVLWSCVTCGACV FT EQCPVDIEHVDHIVDMRRYQVMMESEFPSELSVLFKNLETKGNPWGQNASDRTNWIDEV FT DFDVPVYGQDVDSFDGYEYLFWVGCAGAYDDKAKKTTKAVAELLAVARVKYLVLGAGET FT CNGDSARRSGNEFLFQQLAQQAVETLDGLFEGVETVDRKIVVTCPHCFNTIGKEYRQLG FT ANYTVLHHTQLLNRLVRDKRLVPVTPVSQDITYHDPCYLGRHNKAYEAPRELIGAAGAS FT LTEMPRHADRSFCCGAGGARMWMEEHIGKRINHERVDEALATDATAIATACPFCRVMVT FT DGVNDRQEEAGRSGVEVLDVAQVLLGSLDHDKAQLPAKGTAAKQAQERAPKAAPKAAAP FT VTPVEAPAEAPQAPAPAAPAAPVKGLGMAAGAKRPGAKKAAPTPAAPAAPAAPVKGLGI FT AAGAKRPGAKKTPPPAPGLAEPAAQPQPEAKPQPEPAAPPKPQTDGDPAAPAAPVKGLG FT IARGARPPGKR" FT misc_feature complement(62369..62404) FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT misc_feature complement(62726..62761) FT /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding regi FT on signature" FT misc_feature complement(63017..63052) FT /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding regi FT on signature" FT CDS complement(64043..66541) FT /transl_table=11 FT /locus_tag="Rv0339c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0339c, (MTCY279.06c), len: 832 aa. Possible FT transcriptional regulator, showing very weak similarity FT with parts of others. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop ); and probable helix-turn helix motif from FT aa 778-799 (Score 1041, +2.73 SD)." FT /db_xref="GOA:O33269" FT /db_xref="HSSP:1FSE" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:O33269" FT /protein_id="CAB10794.1" FT /translation="MQHRGCKNRGQAYDASVTDSLTEVPPAARRALLELANAPTVPVKV FT LITGGIGTGKTTVLAAARDTLRRSGLTVLACPPPDGEPPETALVIDDAQLLTDTELLRL FT TERVADSRLTVVAAAEAREHHRALRALTMALERDRPRISLGPLPVAEHLRDCTAGLPFL FT IHAVSARAQAPAQAAKVALIERLRRLDEPTLDTLLMMSLTHELGVSDVAAALGISVTDA FT RGLVDRAHASGLIESSHTAAFLQSVHDAIAQIVGNAHHHEVETSLLRSQLDISPVSAEL FT ALRLAEHGLRDERLADILTRYAADTRDASVRCARLYRAAVHAGAKGLTVRLADALARTG FT DCTAAATLADDLLSSPDATERAAAVRVAASVAVHDGNTGHAAELFGWLGPHPDTMVSSA FT ATIVFAANGDLATARATLRLKDAGPPTMAARCARNLAEGLLLTMDQPYPVAMAKLGQAI FT ATEQSLSQVIPDSPAALVTLAAIHAGDPVRARSVIGRAVRAGADPLFQRRHLLLSGWIK FT MQEGQLPSASADVAAASAGTHLHRRDALWAAALQTAISRRTGDIGALQQHWYAAMEALA FT EYSLDLFALLPLGELWVAAARMRQVDQLQHTLDQALTLLDSLGNPALWSNSLHWAGVHA FT GILANSPESVAPHGQALGAMVAHSTLAQALSDAGRTWLRVLAENVDADEVTAAARSLSH FT VGLTSDATRLAGQAALQTSDARVSGAMLQLARDLKLGNDFGEPPSGAGDTEPASGTPPA FT PRQPPAGSPLSDREREVAELLLLGMPYRDIGARLFISAKTVEHHVARIRQRLGAGSRSE FT MLSMLRAMLAPESLTADERR" FT misc_feature complement(66374..66397) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 66727..67266 FT /transl_table=11 FT /locus_tag="Rv0340" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0340, (MTCY279.07), len: 179 aa. Conserved FT hypothetical protein; MEME-MAST analysis shows similarity FT to product of downstream gene, Rv0341|iniB." FT /db_xref="UniProtKB/TrEMBL:O33270" FT /protein_id="CAB10795.1" FT /translation="MANSLLDFVISLVRDPEAAARYAANPERSIAEAHLTDVTRADVNS FT LIPVVSDSLSMSEPIGAAGGAHAGDRGNVWASGAATAALDAFAPHADAGVVQQHGAVGS FT VLNQPTPPGPGVTPTDPRPFRAGPHETSALLTSAEIPDTTSEDGGLPTDHPAVWNHPVV FT DPHTVEPDHHGYDIHG" FT CDS 67455..68894 FT /transl_table=11 FT /gene="iniB" FT /locus_tag="Rv0341" FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIB" FT /function="UNKNOWN" FT /note="Rv0341, iniB, (MTCY13E10.01), len: 479 aa. iniB, FT isoniazid-inducible gene, (see citations below). Protein FT very Gly-, Ala-rich, similar to cell wall proteins e.g. FT P27483|GRP_ARATH GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN FT from A.thaliana (338 aa), FASTA scores: opt: 532, E(): FT 5.2e-13, (39.3% identity in 321 aa overlap). MEME-MAST FT analysis shows similarity to product of upstream gene, FT Rv0340." FT /db_xref="InterPro:IPR002202" FT /db_xref="UniProtKB/TrEMBL:O06292" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08573.1" FT /translation="MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISSV FT AANVVPGLNLGAGDPMSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAGLA FT SGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGTGLG FT AQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRLGGNGQIGVAGQGAVGAGVGA FT GVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGA FT AMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAAAGVVGG FT VGGATAAGVGGAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGGTGGYGGM FT NPPVTDAPAPQVPARAQPMTTAAEHTPAVTQPQHTPVEPPVHDKPPSHSVFDVGHEPPV FT THTPPAPIELPSYGLFGLPGF" FT CDS 68931..70853 FT /transl_table=11 FT /gene="iniA" FT /locus_tag="Rv0342" FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIA" FT /function="UNKNOWN" FT /note="Rv0342, iniA, (MTCY13E10.02), len: 640 aa. iniA, FT isoniazid-inducible gene, (see citations below). Shows FT slight similarity to some hypothetical bacterial proteins FT e.g. P40983|YOR6_THER hypothetical protein (402 aa), FASTA FT scores: opt: 242, E(): 1.4e-07, (22.3% identity in 349 aa FT overlap). Also some similarity to downstream ORF FT Rv0343|iniC. Possible transmembrane stretch around residue FT 490. Alternative translational start at 410824. Contains a FT phosphopantetheine attachment site motif suggestive of an FT acyl carrier protein. Note that the iniA gene is also FT induced by the antibiotic ethambutol, an agent that FT inhibits cell wall biosynthesis by a mechanism that is FT distinct from isoniazid." FT /db_xref="UniProtKB/TrEMBL:O06293" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08574.1" FT /translation="MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIA FT IAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEAT FT VVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAP FT SPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAH FT QICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELN FT EESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRL FT ASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCD FT PTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHV FT MGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAG FT LILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYRE FT IAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRA FT SLGRA" FT CDS 70850..72331 FT /transl_table=11 FT /gene="iniC" FT /locus_tag="Rv0343" FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIC" FT /function="UNKNOWN" FT /note="Rv0343, (MTCY13E10.03), len: 493 aa. iniC, FT isoniazid-inducible gene, (see citations below). Shows FT slight similarity to P40983|YOR6_THER8 hypothetical protein FT (402 aa), FASTA scores: opt: 196, E(): 2.6e-05, (25.9% FT identity in 228 aa overlap). Also some similarity to FT upstream ORF Rv0342|iniA. Contains (PS00017) FT ATP/GTP-binding site motif A (P-loop). Note that the iniA FT gene is also induced by the antibiotic ethambutol, an agent FT that inhibits cell wall biosynthesis by a mechanism that is FT distinct from isoniazid." FT /db_xref="UniProtKB/TrEMBL:O06294" FT /protein_id="CAB08575.1" FT /translation="MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEPL FT RIALAGTLKAGKSTLVNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRANV FT PITRRGGLSFDLRRINPAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLRLLV FT PADGVPRVDAVVFLLRTLNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAGRIDA FT MLSANDVAKRFTRELNQMGICQAVVPVSGLLALTARTLRQTEFIALRKLAGAERTELNR FT ALLSVDRFVRRDSPLPVDAGIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAAELLERS FT GLVALRNVIDQQFAQRSDMLKAHTALVSLRRFVQTHPVPATPYVIADIDPLLADTHAFE FT ELRMLSLLPSRATTLNDDEIASLRRIIGGSGTSAAARLGLDPANSREAPRAALAAAQHW FT RRRAAHPLNDPFTTRACRAAVRSAEAMVAEFSARR" FT misc_feature 71000..71023 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(72474..73034) FT /transl_table=11 FT /gene="lpqJ" FT /locus_tag="Rv0344c" FT /product="PROBABLE LIPOPROTEIN LPQJ" FT /function="UNKNOWN" FT /note="Rv0344c, (MTCY13E10.04c), len: 186 aa. Probable FT lipoprotein, without homology. Has an appropriately FT positioned prokaryotic lipoprotein signature (PS00013)." FT /db_xref="UniProtKB/TrEMBL:O06295" FT /protein_id="CAB08576.1" FT /translation="MRLSLIARGMAALLAATALVAGCNTTIDGRPVASPGSGPTEPTFP FT TPRPTTAPPGTTAPTLPTTPVSPTAPAGAIPLPPDSNGYVFIETKSGMTRCQINRDSVG FT CEAPFTNSPLRDGEHANGIHITAGGSVQWVLGNLGAIPTVSIDYRTYEAQGWTIDATTD FT GTRFTNNRTGHGMFVSIEKVDTF" FT misc_feature complement(72966..72998) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid attac FT hment site" FT CDS 73143..73553 FT /transl_table=11 FT /locus_tag="Rv0345" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0345, (MTCY13E10.05), len: 136 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from FT Streptomyces coelicolor (207 aa), FASTA scores: opt: 188, FT E(): 1.5e-05, (41.0% identity in 117 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06296" FT /protein_id="CAB08577.1" FT /translation="MLPSTVVGVLLAAGAGRWYGKPKVLVDGWLDTAVGALRDGGCNDV FT ILVLGAVEVSAPAGVTAITAPDWQQGLSASVRAGLAQADREHADYAVLHVIDTPDVNAK FT VVARVLGRALVSRSGLAGRGRIPAHSARRRGC" FT CDS complement(73595..75058) FT /transl_table=11 FT /gene="ansP2" FT /locus_tag="Rv0346c" FT /standard_name="aroP2" FT /product="POSSIBLE L-ASPARAGINE PERMEASE ANSP2 FT (L-ASPARAGINE TRANSPORT PROTEIN)" FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF FT L-ASPARAGINE ACROSS THE MEMBRANE. RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv0346c, (MTCY13E10.06c), len: 487 aa. Possible FT ansP2, L-asparagine permease, integral membrane protein FT belonging to family containing many amino acid permeases, FT highly similar to G467030|B2126_F2_85|NP_301937.1|NC_002677 FT probable L-asparagine permease from Mycobacterium leprae FT (498 aa); and NP_301938.1|NC_002677 probable L-asparagine FT permease from Mycobacterium leprae (505 aa). Also highly FT similar to others e.g. P77610|ANSP_ECOLI L-ASPARAGINE FT PERMEASE from Escherichia coli strain K-12 (499 aa). Also FT highly similar to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 FT PROBABLE L-ASPARAGINE PERMEASE from Mycobacterium FT tuberculosis (489 aa), FASTA score: (72.1% identity in 473 FT aa overlap). And shows some similarity to MTCY3G12.14 from FT Mycobacterium tuberculosis. BELONGS TO THE AMINO ACID FT PERMEASE FAMILY (APC FAMILY). Note that previously known as FT aroP2." FT /db_xref="GOA:P0A4W0" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/Swiss-Prot:P0A4W0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55273.1" FT /translation="MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGAG FT GRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGSFVSYAREFYGEKVAFVAGW FT MYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLALIALLVVLSMNLISVRLFGELEF FT WASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTGLLPIVLVTSGVV FT FAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAYKEHVS FT PFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRFTAPMSK FT TGVPYGGILLTAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMA FT NAGQLQRPKFRMPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWY FT LVRNRVTAVAHHAIDHTKSVAVVHSADPI" FT CDS 75397..76383 FT /transl_table=11 FT /locus_tag="Rv0347" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0347, (MTCY13E10.07), len: 328 aa (alternative FT start possible). Probable conserved membrane protein, FT similar to Rv0831c|AL022004|MTV043_23 from Mycobacterium FT tuberculosis (271 aa), FASTA scores: E(): 9.6e-21, (33.1% FT identity in 266 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06298" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08579.1" FT /translation="MPGARELTLRVERGALFRRRWAASAASSARAAIRRDPRRCALGTR FT PRWVSFLVIVLVIMNVVTAHPKYPNDPLALVLIELRHPRTEPPVPSAISILKEELARWT FT PILEQEEVRQVNLETGEHTAHSQKKLVARDRRTAITFRPDAMTLEVTDYPGWEEFRSIV FT HAMVTARQDVAPVDGCIRIGLRYINEIRASLAEPSGWAYWVAESLLGPGTQLADLKLTT FT TAQRHVIQCEGPEPGDSLTLRYAGARGAVIQSTPFLQRLKEPPAEGDFFLIDIDSAWSD FT PCKGIPALDAHLVDEVAERLHTPIGPLFESLITSELRTKVLQQPGQE" FT CDS 76386..77039 FT /transl_table=11 FT /locus_tag="Rv0348" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0348, (MTCY13E10.08), len: 217 aa. Possible FT transcriptional regulator, showing some similarity to FT O53334|RV3188|MTV014.32 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (115 aa), FASTA score: (30.0% FT identity in 100 aa overlap). Contains probable helix-turn FT helix motif from aa 89-110 (Score 1407, +3.98 SD)." FT /db_xref="UniProtKB/TrEMBL:O06299" FT /protein_id="CAB08580.1" FT /translation="MTISFSSSNLRDDATSGNGDYRLDKLPETTPSTSVFDRADVTYRQ FT FTELHGQARDTRREAHVVELESKTGERARCAPMHALEQLADYGFAWRDIARVVGVSVPA FT ITKWRKGAGVTGENRLKIARLLALIDMLSDRFIGEPASWLEMPIQAGVGITRMDLLERG FT RYDLVLALASTHTGDGTVEYVLNETDKDWRETVVDNAFESYTAEDGVISIRPKR" FT CDS 77042..77701 FT /transl_table=11 FT /locus_tag="Rv0349" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0349, (MTCY13E10.09), len: 219 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O06300" FT /protein_id="CAB08581.1" FT /translation="MPELETPDDPESIYLARLEDVGEHRPTFTGDIYRLGDGRMVMILQ FT HPCALRHGVDLHPRLLVAPVRPDSLRSNWARAPFGTMPLPKLIDGQDHSADFINLELID FT SPTLPTCERIAVLSQSGVNLVMQRWVYHSTRLAVPTHTYSDSTVGPFDEADLIEEWVTD FT RVDDGADPQAAEHECASWLDERISGRTRRALLSDRQHASSIRREARSHRKSVKLAD" FT CDS 77928..79805 FT /transl_table=11 FT /gene="dnaK" FT /locus_tag="Rv0350" FT /standard_name="hsp70" FT /product="PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK FT PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70)" FT /function="ACTS AS A CHAPERONE. INVOLVED IN INDUCTION BY FT STRESS CONDITIONS e.g. HEAT SHOCK. POSSIBLY HAS AN ATPASE FT ACTIVITY. SEEMS TO BE REGULATED POSITIVELY BY SIGH (Rv3223c FT PRODUCT) AND NEGATIVELY BY HSPR (Rv0353 PRODUCT)." FT /EC_number="3.6.1.-" FT /note="Rv0350, (MTCY13E10.10), len: 625 aa. Probable dnaK FT (alternate gene name: hsp70), 70 kDa heat shock protein FT (see citations below), equivalent to FT AAA25362.1|M95576|1924344A|738248 heat shock protein 70 FT from Mycobacterium leprae (621 aa); and DNAK_MYCPA|Q00488 FT (623 aa), FASTA scores: opt: 3678, E(): 0, (92.3% identity FT in 625 aa overlap). Also highly similar to others e.g. FT Q05558|DNAK_STRCO|453231|CAA54606.1|X77458 CHAPERONE FT PROTEIN DNAK from Streptomyces coelicolor (618 aa). Has FT probably an ATPase activity (EC 3.6.1.-). Note that this FT sequence differs from DNAK_MYCTU|P32723 (609 aa), due to a FT frameshift near the N-terminus. BELONGS TO THE HEAT SHOCK FT PROTEIN 70 FAMILY." FT /db_xref="GOA:P0A5B9" FT /db_xref="HSSP:1DG4" FT /db_xref="InterPro:IPR013126" FT /db_xref="UniProtKB/Swiss-Prot:P0A5B9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08582.1" FT /translation="MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARN FT GEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRDAE FT AYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKE FT QRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGI FT DLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRI FT TQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVN FT PDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSET FT FTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIV FT HVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLV FT YQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSAMEKLGQESQA FT LGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREAK" FT CDS 79802..80509 FT /transl_table=11 FT /gene="grpE" FT /locus_tag="Rv0351" FT /product="PROBABLE GRPE PROTEIN (HSP-70 COFACTOR)" FT /function="STIMULATES, JOINTLY WITH DNAJ|Rv0352, THE ATPASE FT ACTIVITY OF DNAK|Rv0350. HELPS TO RELEASE ADP FROM DNAK FT THUS ALLOWING DNAK TO RECYCLE MORE EFFICIENTLY. SEEMS TO BE FT REGULATED NEGATIVELY BY HSPR (Rv0353 PRODUCT)." FT /note="Rv0351, (MTCY13E10.11), len: 249 aa. Probable grpE FT protein (HSP-70 COFACTOR), equivalent to FT CAC32012.1|AL583925 Hsp70 cofactor from Mycobacterium FT leprae (229 aa). Also highly similar to others eg FT Q05562|GRPE_STRCO|2127521|PN0643 GRPE PROTEIN from FT Streptomyces coelicolor (225 aa). Contains grpE protein FT signature (PS01071). BELONGS TO THE GRPE FAMILY." FT /db_xref="GOA:P32724" FT /db_xref="HSSP:1DKG" FT /db_xref="InterPro:IPR009012" FT /db_xref="UniProtKB/Swiss-Prot:P32724" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08583.1" FT /translation="MTDGNQKPDGNSGEQVTVTDKRRIDPETGEVRHVPPGDMPGGTAA FT ADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLER FT ARKHGDLESGPLKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEGDGGQGSKPV FT IGTVMRQGYQLGEQVLRHALVGVVDTVVVDAAELESVDDGTAVADTAENDQADQGNSAD FT TSGEQAESEPSGS" FT misc_feature 80225..80359 FT /note="PS01071 grpE protein signature" FT CDS 80545..81732 FT /transl_table=11 FT /gene="dnaJ1" FT /locus_tag="Rv0352" FT /standard_name="dnaJ" FT /product="PROBABLE CHAPERONE PROTEIN DNAJ1" FT /function="ACTS AS A CO-CHAPERONE. STIMULATES, JOINTLY WITH FT GRPE|Rv0351, THE ATPASE ACTIVITY OF DNAK|Rv0350. SEEMS TO FT BE REGULATED NEGATIVELY BY HSPR (Rv0353 PRODUCT)." FT /note="Rv0352, (MTCY13E10.12), len: 395 aa. Probable dnaJ1, FT chaperone protein, equivalent to AAA25363.1|M95576 DNA J FT heatshock protein from Mycobacterium leprae (389 aa). Also FT highly similar to others. Contains both DnaJ signatures FT (PS00636, and PS00637). BELONGS TO THE DNAJ FAMILY. FT COFACTOR: BINDS TWO ZINC IONS PER MONOMER. Note that FT sequence differs from DNAJ_MYCTU|P07881 due to a frameshift FT at the N-terminus. Note that previously known as dnaJ." FT /db_xref="GOA:P0A548" FT /db_xref="HSSP:1HDJ" FT /db_xref="InterPro:IPR001305" FT /db_xref="UniProtKB/Swiss-Prot:P0A548" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55274.1" FT /translation="MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGN FT PAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGD FT GAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAK FT GVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGS FT GSIIEHPCEECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTV FT HVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRG FT RGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR" FT misc_feature 80698..80757 FT /note="PS00636 Nt-dnaJ domain signature" FT misc_feature 81073..81147 FT /note="PS00637 CXXCXGXG dnaJ domain signature" FT CDS 81732..82112 FT /transl_table=11 FT /gene="hspR" FT /locus_tag="Rv0353" FT /product="PROBABLE HEAT SHOCK PROTEIN TRANSCRIPTIONAL FT REPRESSOR HSPR (MERR FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL REGULATION FT (REPRESSION) OF HEAT SHOCK PROTEINS e.g. DNAK|Rv0350, FT GRPE|Rv0351, DNAJ1|Rv0352. BINDS TO THREE INVERTED REPEATS FT (IR1-IR3) IN THE PROMOTER REGION OF THE DNAK OPERON. FT INDUCTION: BY HEAT SHOCK." FT /note="Rv0353, (MTCY13E10.13), len: 126 aa. Probable hspR, FT heat shock regulatory protein (see Stewart et al., 2001), FT merR family, highly similar to others e.g. HspR|P40183 heat FT shock regulatory protein from Streptomyces coelicolor (151 FT aa), FASTA scores: E(): 4.9e-22, (55.7% identity in 140 aa FT overlap), that binds to three inverted repeats (IR1-IR3) in FT the promoter region of the dnaK operon. Has possible coiled FT coil region in C-terminal half. BELONGS TO THE MERR FAMILY FT OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:O06302" FT /db_xref="HSSP:1JBG" FT /db_xref="InterPro:IPR000551" FT /db_xref="UniProtKB/TrEMBL:O06302" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08585.1" FT /translation="MAKNPKDGESRTFLISVAAELAGMHAQTLRTYDRLGLVSPRRTSG FT GGRRYSLHDVELLRQVQHLSQDEGVNLAGIKRIIELTSQVEALQSRLQEMAEELAVLRA FT NQRREVAVVPKSTALVVWKPRR" FT CDS complement(82362..82787) FT /transl_table=11 FT /gene="PPE7" FT /locus_tag="Rv0354c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0354c, (MTCY13E10.14c), len: 141 aa. Member of the FT Mycobacterium tuberculosis PPE family, similar to others FT e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 aa), FT FASTA scores: E(): 3.6e-11, (47.6% identity in 103 aa FT overlap). Possible continuation of ORF upstream, but no FT sequence error apparent." FT /db_xref="UniProtKB/TrEMBL:Q6MX45" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55275.1" FT /translation="MSVCVIYIPFKGCVKHVSVTIPITTEHLGPYEIDASTINPDQPID FT TAFTQTLDFAGSGTVGAFPFGFGWQQSPGFFNSTTTPSSGFFNSGAGGASGFLNDAAAA FT VSGLGNVFTETSGFFNAGGVGIRASKTSATCCRAGRT" FT CDS complement(82870..92772) FT /transl_table=11 FT /gene="PPE8" FT /locus_tag="Rv0355c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0355c, (MTCY13E10.15c, MTCY13E10.16c, FT MTCY13E10.17c) len: 3300 aa. Member of the Mycobacterium FT tuberculosis PPE family, similar to others e.g. FT AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 FT aa), FASTA scores: opt: 2906, E(): 0, (40.9% identity in FT 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in FT 3531 aa overlap); etc. Gene contains large number of FT clustered Major Polymorphic Tandem Repeats (MPTR). Related FT to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17, FT E(): 0; MTCY98.0034c, E(): 0; MTCY03C7.23 E(): 0; FT MTCY98.0031c, E(): 0; MTCY31.06c, E(): 5.6e-17; MTCY359.33, FT E(): 2.3e-16." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q6MX44" FT /protein_id="CAE55276.1" FT /translation="MSFAVLPPEINSARLYVGAGLAPMLDAAAAWDGLADELGSAAASF FT SAVTAGLAGSSWLGAASTAMTGAAAPYLGWLSAAAAQAQQAATQTRLAAAAFEAALAAT FT VHPAIISANRALFVSLVVSNLLGQNAPAIAATEAAYEQMWAQDVAAMFGYHAGASAAVS FT ALTPFGQALPTVAGGGALVSAAAAQVTTRVFRNLGLANVGEGNVGNGNVGNFNLGSANI FT GNGNIGSGNIGSSNIGFGNVGPGLTAALNNIGFGNTGSNNIGFGNTGSNNIGFGNTGDG FT NRGIGLTGSGLLGFGGLNSGTGNIGLFNSGTGNVGIGNSGTGNWGIGNSGNSYNTGFGN FT SGDANTGFFNSGIANTGVGNAGNYNTGSYNPGNSNTGGFNMGQYNTGYLNSGNYNTGLA FT NSGNVNTGAFITGNFNNGFLWRGDHQGLIFGSPGFFNSTSAPSSGFFNSGAGSASGFLN FT SGANNSGFFNSSSGAIGNSGLANAGVLVSGVINSGNTVSGLFNMSLVAITTPALISGFF FT NTGSNMSGFFGGPPVFNLGLANRGVVNILGNANIGNYNILGSGNVGDFNILGSGNLGSQ FT NILGSGNVGSFNIGSGNIGVFNVGSGSLGNYNIGSGNLGIYNIGFGNVGDYNVGFGNAG FT DFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNIASGWNSGTGNSGLFNSGTNNV FT GIFNAGTGNVGIANSGTGNWGIGNPGTDNTGILNAGSYNTGILNAGDFNTGFYNTGSYN FT TGGFNVGNTNTGNFNVGDTNTGSYNPGDTNTGFFNPGNVNTGAFDTGDFNNGFLVAGDN FT QGQIAIDLSVTTPFIPINEQMVIDVHNVMTFGGNMITVTEASTVFPQTFYLSGLFFFGP FT VNLSASTLTVPTITLTIGGPTVTVPISIVGALESRTITFLKIDPAPGIGNSTTNPSSGF FT FNSGTGGTSGFQNVGGGSSGVWNSGLSSAIGNSGFQNLGSLQSGWANLGNSVSGFFNTS FT TVNLSTPANVSGLNNIGTNLSGVFRGPTGTIFNAGLANLGQLNIGSANLGDFNLGSGNV FT GSFNVFSGNQGSYNIGPANLGNYNIGFANLGNYNIGFGNAGDFNQGFANTGNNNIGFAN FT TGNNNIGIGLSGDNQQGFNFAGGWNSGTANIGLFNSGTNNVGIGNSGTGNWGIGNSGSG FT NTGIGNTGSTNTGFFNTGIVNTGVANAGSYNTGWYNTGDTNTGIANLGDFNTGFYNTGN FT FSTGFANQGDIATGAFITGDMGNGAFWRGDQQGLFSAGYRVHVPEIPAHVTVEVPVNIP FT ITASFTNTVYSGITLEQINFGFTIDIAGIPLLAGAISKAVLPPITGTGPAITVNIGDPG FT GSTAIRIPATASVGPFDVTFVNIAATTGFFNATTDPSSGFFNGGPGTVSGIANIGANIS FT GFQNVANSATSGFNNYGSLQSGLANLGDTVSGVFNTGIGAPANVSGMFNIGSNLAGFFH FT DQATGMSMFNLGLGNIGQFNVGFSNVGDSNAGLANIGSFNLGSGNLGSFNVFGGNQGSY FT NIGPANLGNYNIGLGNLGSYNFGFGNAGDFNLGFANTGNNNIGFANTGNNNIGIGLSGD FT NQQGFNFAGGWNSGSGNSGLFNSGTNNIGLFNSGTGNIGIGNSGTGNWGIANTGDTNTG FT IFNTGDVNTGLLNAGNVNTGIFNTGHYNTGSFNAGSFNTAGFNPGSYNTGYLNTGSYNT FT GLANSGDVNTGGFITGNYSNGFWWRGDYQGLAGISQTITVPDTAVPVKLHVPIFLDIPV FT TGTLGTFTVHGFRFPEITGDIFLIGIPFNAATLDAFSFPNISIVLPNIGINLGSGPDPL FT IDIAGTGGLLPIKIPLIDIPAAPGFGNSTTTPSSGFFNAGTGTVSGVGNVGSNSSGFFN FT LTSGSSGISGVQNFGELISGGFNFGNTVSGLVNASTLGLSMPANLSGGGNVGATVAGFV FT NNTQILNLGFGNVGSGNVGHGNIGDSNVGLGNLGNANVGHGNIGSFNVFSGNRGSYNIG FT PANLGNYNIGLGNLGSYNFGFGNAGDFNLGFANSGSNNIGFANTGNNNIGIGLSGHNQQ FT GFGSWNSGTANTGLFNSGTNNIGLFNSGTGNIGIGNSGIGNTGIGNPGVGNTGLGNSGT FT GNWGLWNPGTGNMGVANVGTYNTGGYNVGSTNTGIANVGIANTGSYNTGSTNTGSFNDG FT DFNTGFYNTGDYNTGFYNTGDVNTGAFIGGNFSNGAFWQSDHQGQWGAHYAITVPQIPL FT LNFSLNIPVNIPIHLDFGTLAVNGFQIPAITLRALGVTHFSVGPIIVPRIAGTLPVIDI FT NIGDPGGSSSIPITITSGAGPVVIPLLDIPPAPGFGNSTTGPSSGFFNSGTGSSSGFGN FT VGANNSGFWNTAFAGIGNSGLQNFGSLQSGWANLGNTVSGFYNTSAADFATPANLSGLS FT NVGADLTGVLRGPNGSTFNAGLANLGQFNVGSANLGSANLGSANLGSANLGNSNVGFGN FT IGNANIGGANIGDFNVGIANTGPGLTAAVNNIGIGNTGNYNIGVGNTGNYNIGFGNTGN FT NNIGIGLSGDNQIGFGPLNAGIANMGLFNLGDNNFGMANAGNFNQGIANTGNNNIGLFN FT TGNNNVGIWLTGDGLSGFSSLNSGAGNTGFFNSGTANTGLFNSGTGNTGLFNSGTGNVG FT IGNMGTGGFGVGLSGDSQVGIGGTNSGSFNIGLFNSGTGNVGIGNSGTGNVGIGNTGTG FT NTGIGNSGNYNTGLLNAGLVNTGIANPGNHNTGLFNIGTFNTGIANPGHYNTGSYNTGS FT YNTGMANAGDYGTGAFITGSMNNGLLWRADRQGLLAANYTITIERPAAFLNVDIPVNIP FT ITGDITNVSIPAITFPRIDASGSVDIGILSGTVLAPVGPITLHGGDASAPLDTPIEIDF FT GPSPAINLNIGKPDGSTVINIVGGAGAGPISIPIIDLRPAPGFFNATTGPSSGFLNWGA FT GSASGLLNFGNNSGLYNFATSSMGNSGFQNYGSLQSGWANLGNSISGIYNTGLGAPANV FT SGLLNIGTNLAGWLQNGPTETTFSVGLANLGFWNLGSANIGNYNLGSANIGVYNLGSAN FT IGDFNLGSANIGDFNLGSANIGSSNIGFGNVGPGLTAAIGNIGFGNTGNGNIGIGNTGT FT GNIGFGNTGNGNIGIGLTGDTMTGFGGWNSGTGNIGLFNSGTGNIGFGNSGTGNWGIGN FT SGDYNTGIGNTGSTNSGFFNTGLVNTGIGNSGDYNTGLFNAGNTNTGSFNPGDYNTGGF FT NPGNYNTGYFNPGNSNTGIANSGDVNTGAFNSGNYSNGFFWRGDYQGLGGFAYQSAVSE FT IPWSYDRFQH" FT CDS complement(92923..93567) FT /transl_table=11 FT /locus_tag="Rv0356c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0356c, (MTCY13E10.18c), len: 214 aa. Conserved FT hypothetical protein, equivalent to AL023514|MLCB4_12 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae FT (218 aa), FASTA scores: opt: 1067, E(): 0, (73.4% identity FT in 214 aa overlap)." FT /db_xref="InterPro:IPR006683" FT /db_xref="UniProtKB/TrEMBL:O06307" FT /protein_id="CAB08564.1" FT /translation="MTDASVHPDELDPEYHHHGGFPEYGPASPGAGFGQFVATMRRLQD FT LAVAADPGDAVWDEAAERAAALVELLSPFEADEGKAPAGRTPGLPGMGSLLLPPWTVTR FT YGTDGVEMRGSFSRFHVGGNSAVHGGVLPLLFDHMFGMISHAAGRPISRTAFLHVDYRR FT ITPIDVPLIVRGRVTNTEGRKAFVCAELFDSDETLLAEGNGLMVRLLPGQP" FT CDS complement(93564..94862) FT /transl_table=11 FT /gene="purA" FT /locus_tag="Rv0357c" FT /product="PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA FT (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)" FT /function="INVOLVED IN AMP BIOSYNTHESIS (FIRST COMMITTED FT STEP). PLAYS AN IMPORTANT ROLE IN THE DE NOVO PATHWAY OF FT PURINE NUCLEOTIDE BIOSYNTHESIS [CATALYTIC ACTIVITY: GTP + FT IMP + L-aspartate = GDP + phosphate + adenylosuccinate]." FT /EC_number="6.3.4.4" FT /note="Rv0357c, (MTCY13E10.19c), len: 432 aa. Probable FT purA, adenylosuccinate synthase (EC 6.3.4.4), equivalent to FT AL023514|MLCB4_13 from ADENYLOSUCCINATE SYNTHETASE FT Mycobacterium leprae (432 aa), FASTA scores: opt: 2555, FT E(): 0, (87.9% identity in 431 aa overlap). Also highly FT similar to many bacterial adenylosuccinates synthetases FT e.g. P12283|PURA_ECOLI adenylosuccinates synthetase from FT Escherichia coli (431 aa), FASTA scores: E(): 0, (51.1% FT identity in 425 aa overlap); etc. BELONGS TO THE FT ADENYLOSUCCINATE SYNTHETASE FAMILY." FT /db_xref="GOA:P65880" FT /db_xref="HSSP:1ADE" FT /db_xref="InterPro:IPR001114" FT /db_xref="UniProtKB/Swiss-Prot:P65880" FT /protein_id="CAB08565.1" FT /translation="MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVL FT PTGENFALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISADAH FT LLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHKVEA FT ACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETVLLEG FT SQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSGPFPTE FT LFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLES FT VPVCVGYEIDGRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVL FT RLEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP" FT CDS 94953..95600 FT /transl_table=11 FT /locus_tag="Rv0358" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0358, (MTCY13E10.20), len: 215 aa. Conserved FT hypothetical protein, highly similar to FT ML0281|AL023514|MLCB4_14 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (229 aa), FASTA scores: opt: 852, FT E(): 0, (62.9% identity in 229 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06308" FT /protein_id="CAB08566.1" FT /translation="MYTAENAPGVAVLLSGDADVPGPLTGLPTHQDNLDTVIGRYSRLI FT VVGADADLGAVLTRLLRTDRLDVEVGYVPRRRSPATRAYRLPAGRRAARRARCGVARRV FT PLIRDETGSVIVGRAQWLPAEEQALIHGEAVVDDTVLFDGDVAGVCIEPTLTLPGLRAA FT VDGAGKWRRWIGGRAAQLGTTGAAVLRDGVAAPRPVRRSTFYRNVEGWLLVR" FT CDS 95611..96390 FT /transl_table=11 FT /locus_tag="Rv0359" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0359, (MTCY13E10.21), len: 259 aa. Probable FT conserved integral membrane protein, highly similar to FT hypothetical or other membrane proteins e.g. FT AL133220|SCC75A_6|T50569 probable membrane protein from FT Streptomyces coelicolor (265 aa), FASTA scores: opt: 642, FT E(): 0, (43.1% identity in 248 aa overlap); P70995 FT HYPOTHETICAL 24.7 kDa PROTEIN from Bacillus subtilis (219 FT aa), FASTA scores: E(): 1.5e-12, (31.3% identity in 192 aa FT overlap). Contains neutral zinc metallopeptidases, FT zinc-binding region signature (PS00142)." FT /db_xref="GOA:O06309" FT /db_xref="InterPro:IPR008915" FT /db_xref="UniProtKB/TrEMBL:O06309" FT /protein_id="CAB08567.1" FT /translation="MSETGQRESVRPSPIFLGLLGLTAVGGALAWLAGETVQPLAYAGV FT FVMVIAGWLVSLCLHEFGHAFTAWRFGDHDVAVRGYLTLDPRRYSHPMLSLGLPMLFIA FT LGGIGLPGAAVYVHTWFMTTARRTLVSLAGPTVNLALAMLLLAATRLLFDPIHAVLWAG FT VAFLAFLQLTALVLNLLPIPGLDGYAALEPHLRPETQRALAPAKQFALVFLLVLFLAPT FT LNGWFFGVVYWLFDLSGVSHRLAAAGSVLARFWSIWF" FT misc_feature 95779..95808 FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS complement(96395..96832) FT /transl_table=11 FT /locus_tag="Rv0360c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0360c, (MTCY13E10.22c), len: 145 aa. Conserved FT hypothetical protein, equivalent to FT AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c FT hypothetical protein from Mycobacterium leprae (137 aa), FT FASTA scores: opt: 793, E(): 0, (85.4% identity in 137 aa FT overlap). And similar to AL049754|SCH10_25c|T36537 FT hypothetical protein from Streptomyces coelicolor (143 aa), FT FASTA scores: opt: 497, E(): 3.2e-27, (55.8% identity in FT 138 aa overlap)." FT /db_xref="InterPro:IPR014487" FT /db_xref="UniProtKB/TrEMBL:O06310" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08568.1" FT /translation="MTKRTITPMTSMGDLLGPEPILLPGDSDAEAELLANESPSIVAAA FT HPSASVAWAVLAEGALADDKTVTAYAYARTGYHRGLDQLRRHGWKGFGPVPYSHQPNRG FT FLRCVAALARAAAAIGETDEYGRCLDLLDDCDPAARPALGL" FT CDS 96915..97742 FT /transl_table=11 FT /locus_tag="Rv0361" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0361, (MTCY13E10.23), len: 275 aa. Probable FT conserved membrane protein (has hydrophobic stretch from FT residues 132-156), equivalent to FT AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane FT protein from Mycobacterium leprae (292 aa), FASTA scores: FT opt: 1044, E(): 0, (58.6% identity in 292 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O06311" FT /protein_id="CAB08569.1" FT /translation="MSNAPEPDRSAGESGSEPAGERSADPGEERTESYPLVPHDAETET FT VVITTSDNDAAVTQPEAQRERRFTAPGFDAKETQVIVTAHEAATEVFQTNQAPTTPPRM FT PTGMPPKTAVPQSIPPRTEATSVRQRTWGWALAVVVIVLALAAIAILGTVLLTRGKHSK FT MSQEDQVRQAIQSLDIAIQTGDLTALRSLTCGSTRDGYVDYDERDWAETYRRVSAAKQY FT PVIASIDQVVVNGAHAEANVTTFMAFDPQVRSTRSLDLQFRDDQWKICQSSSN" FT CDS 97964..99346 FT /transl_table=11 FT /gene="mgtE" FT /locus_tag="Rv0362" FT /product="POSSIBLE Mg2+ TRANSPORT TRANSMEMBRANE PROTEIN FT MGTE" FT /function="THOUGHT TO BE INVOLVED IN Mg2+ TRANSPORT. FT RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS FT THE MEMBRANE." FT /note="Rv0362, (MTCY13E10.24), len: 460 aa. Possible mgtE, FT magnesium (Mg2+) transport transmembrane protein; FT C-terminal region is highly similar to MGTE|G780283 FT putative Mg2+ transporter from Providencia stuarti (314 FT aa), FASTA scores: E(): 0, (47.2% identity in 307 aa FT overlap) (N-terminus extends approx. 150 aa further FT upstream compared to P. stuarti ORF). Also similar in part FT to others e.g. AAK20879.1|AF334760_1|AF334760 putative Mg2+ FT transporter from Aeromonas hydrophila (455 aa); FT NP_231292.1|NC_002505 magnesium transporter from Vibrio FT cholerae (451 aa); NP_102305.1|NC_002678 Mg2+ transport FT protein from Mesorhizobium loti (454 aa); etc. Also similar FT to Rv1232c|MTV006.04c from Mycobacterium tuberculosis (435 FT aa). Extended hydrophobic segment spanning last 130 FT residues. BELONG TO THE MGTE FAMILY." FT /db_xref="GOA:O06312" FT /db_xref="InterPro:IPR006669" FT /db_xref="UniProtKB/TrEMBL:O06312" FT /protein_id="CAB08570.1" FT /translation="MSIRPAENSTLDIRHVIGIGTPKAVDLWLDVVTELPDRARELGSL FT SKAELGKLGPLLDGTNAVELFESIDDKLAAEALHAMDPSLAATFLEALDSDHAANILRE FT FKEPKREALLTLLPLERAMVLRGLLSWPEDCAAAHMVPETLTVRPNMTVSQAVASVRER FT ASGLRSDARTTAYVYVTDADSHLLGVIAFRALVLANPEQRVRELMGDDLIVVSPLTDKE FT LAAQTIMGHNLMAVPVVDADNRLLGIIAEDEAIDIAEEEATEDAERQGGSAPLEVPYLR FT ASPWLLWRKRVVWLLVLFAAEAYTGSVLRAFSDEMEAVIALAFFIPLLIGTGGNTGTQI FT ATTLVRAMATGQVRFRDVPAVLAKELSTGVLVGLTMAAAAVVRAWTLGVGPQVTLTVAL FT TVAAIVVWSSLVAAVLPPLLKKLRIDPAIVSGPMIATIVDGTGLLIYFLVAHLTLTELH FT GL" FT CDS complement(99358..100392) FT /transl_table=11 FT /gene="fba" FT /locus_tag="Rv0363c" FT /standard_name="fda" FT /product="PROBABLE FRUCTOSE-BISPHOSPHATE ALDOLASE FBA" FT /function="INVOLVED IN GLYCOLYSIS (AT THE SIXTH STEP) FT [CATALYTIC ACTIVITY: D-FRUCTOSE 1,6-BISPHOSPHATE = FT GLYCERONE PHOSPHATE + D-GLYCERALDEHYDE 3-PHOSPHATE]." FT /EC_number="4.1.2.13" FT /note="Rv0363c, (MTCY13E10.25c), len: 344 aa. Probable fba FT (alternate gene name: fda), fructose bisphosphate aldolase FT (EC 4.1.2.13), equivalent to FT AL023514|MLCB4_18|O69600|ALF_MYCLE FRUCTOSE-BISPHOSPHATE FT ALDOLASE from Mycobacterium leprae (345 aa), FASTA scores: FT opt: 1995, E(): 0, (87.7% identity in 342 aa overlap). Also FT highly similar to others. BELONGS TO CLASS II FT FRUCTOSE-BISPHOSPHATE ALDOLASE FAMILY. COFACTOR: ZINC." FT /db_xref="GOA:P67475" FT /db_xref="InterPro:IPR000771" FT /db_xref="PDB:3EKL" FT /db_xref="UniProtKB/Swiss-Prot:P67475" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08571.1" FT /translation="MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAG FT SDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDS FT YVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIG FT VVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKL FT RPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQY FT AFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGK FT SLTH" FT CDS 100488..101171 FT /transl_table=11 FT /locus_tag="Rv0364" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0364, (MTCY13E10.26), len: 227 aa. Possible FT conserved transmembrane protein, equivalent to FT O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLC FT B4 _19 HYPOTHETICAL 24.3 KDA PROTEIN from Mycobacterium FT leprae (222 aa), FASTA scores: opt: 1027, E(): 0, (66.1% FT identity in 227 aa overlap). Shows strong similarity to FT DEDA_ECOLI|P09548 DedA PROTEIN protein from Escherichia FT coli FASTA scores: E(): 1.3e-28, (39.5% identity in 195 aa FT overlap). Similar also to Mycobacterium tuberculosis DedA FT protein Rv2637|MTCY441.0." FT /db_xref="GOA:O06314" FT /db_xref="InterPro:IPR015414" FT /db_xref="UniProtKB/Swiss-Prot:O06314" FT /protein_id="CAB08572.1" FT /translation="MSTAVTAMPDILDPMYWLGANGVFGSAVLPGILIIVFIETGLLFP FT LLPGESLLFTGGLLSASPAPPVTIGVLAPCVALVAVLGDQTAYFIGRRIGPALFKKEDS FT RFFKKHYVTESHAFFEKYGKWTIILARFVPIARTFVPVIAGVSYMRYPVFLGFDIVGGV FT AWGAGVTLAGYFLGSVPFVHMNFQLIILAIVFVSLLPALVSAARVYRARRNAPQSDPDP FT LVLPE" FT CDS complement(101160..102290) FT /transl_table=11 FT /locus_tag="Rv0365c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN: MAY BE INVOLVED IN THE ABILITY TO FT SURVIVE IN MACROPHAGES." FT /note="Rv0365c, (MTCY13E10.27c), len: 376 aa (start FT uncertain). Conserved hypothetical protein (see citation FT below), very similar to G388212|CAA35191.1, a truncated ORF FT immediately upstream of the Corynebacterium glutamicum fda FT gene encoding fructose-1,6-biphosphate aldolase (304 aa), FT FASTA scores: E(): 7.1e-19, (42.2% identity in 296 aa FT overlap)." FT /db_xref="GOA:O06315" FT /db_xref="InterPro:IPR014512" FT /db_xref="UniProtKB/TrEMBL:O06315" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB08588.1" FT /translation="MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLFG FT SWHYWWQAHLLDCLVDAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLALA FT LERADRVAGVRRRRALPKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFLARY FT PDQYGKRLKRAEQMADWIDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLETELA FT VRTGPAARARHCARVHRLVAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALVATTLP FT GDSADDAAARDTARAIVLASAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGEQARSVR FT GAVHSSAIAERDLSVQLSGWMLMEAAHSAAAVSSLG" FT CDS complement(102315..102908) FT /transl_table=11 FT /locus_tag="Rv0366c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0366c, (MTV036.01c), len: 197 aa. Conserved FT hypothetical protein, showing weak similarity to FT HI1395|P44173|YD95_HAEIN HYPOTHETICAL PROTEIN from FT Haemophilus influenzae (140 aa), FASTA scores: opt: 152, FT E(): 0.0015, (27.0% identity in 126 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 FT Glycine radical signature. TBparse score is 0.891." FT /db_xref="InterPro:IPR019777" FT /db_xref="UniProtKB/TrEMBL:O53701" FT /protein_id="CAA17372.1" FT /translation="MKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPD FT DPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSHPSKLELIRTARTAGYTVVLHVLVI FT PEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAGPRI FT VAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA" FT misc_feature complement(102618..102644) FT /note="PS00850 Glycine radical signature" FT misc_feature complement(102861..102884) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(102937..103326) FT /transl_table=11 FT /locus_tag="Rv0367c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0367c, (MTV036.02c), len: 129 aa. Hypothetical FT unknown protein. TBparse score is 0.850." FT /db_xref="UniProtKB/TrEMBL:O53702" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17373.1" FT /translation="MPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVS FT NQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEISAAIEERLSRTNYGDVLAAQGITT FT VALNDAGDIVEHRPDGTSVVLAATP" FT CDS complement(103407..104618) FT /transl_table=11 FT /locus_tag="Rv0368c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0368c, (MTV036.03c), len: 403 aa. Conserved FT hypothetical protein, showing some similarity to FT AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium FT japonicum (422 aa), FASTA scores: opt: 341, E(): 4.3e-13, FT (27.4% identity in 387 aa overlap); Rv2425c|MTCY428_22 FT hypothetical protein from Mycobacterium tuberculosis FASTA FT score: (30.7% identity in 238 aa overlap). Contains PS00213 FT Lipocalin signature. TBparse score is 0.909." FT /db_xref="InterPro:IPR002035" FT /db_xref="UniProtKB/TrEMBL:O53703" FT /protein_id="CAA17374.1" FT /translation="MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQL FT VPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRTPV FT AGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPFDQF FT DPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLLARIR FT PRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLTSVLSH FT RSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDSDPPDVL FT VHALTRVRRRAELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLAL FT AGAR" FT misc_feature complement(104088..104129) FT /note="PS00213 Lipocalin signature" FT CDS complement(104624..105139) FT /transl_table=11 FT /locus_tag="Rv0369c" FT /product="POSSIBLE MEMBRANE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0369c, (MTV036.04c), len: 171 aa. Possible FT membrane protein oxidoreductase (EC 1.-.-.-), similar to FT ORF 4 of the Pseudomonas thermocarboxydovorans protein of FT cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from FT Pseudomonas thermocarboxydovorans (171 aa), FASTA scores: FT opt: 226, E(): 9.8e-08, (31.3% identity in 166 aa overlap). FT Also similar to MTV036.05, MTV036.08, MTV036.09, and FT MTV026.10." FT /db_xref="GOA:O53704" FT /db_xref="InterPro:IPR010419" FT /db_xref="UniProtKB/TrEMBL:O53704" FT /protein_id="CAA17375.1" FT /translation="MPGAQLIGHEGDEYLGKVKVKVGPVTSEFSGKVHFVEQDRNQHRA FT VFDAKGKEARGTGNAAATVAAQLHEVGERTRVTVDTDLKIVGKLAQFGSGMLQQVSEKL FT LGQFVDSLEAELAAQSSESPQGTPPATEAAPIDLLQLADGGQLKKYGSALLAALTVLLL FT IWVLRRRR" FT CDS complement(105240..106136) FT /transl_table=11 FT /locus_tag="Rv0370c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0370c, (MTV036.05c), len: 298 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to many hypothetical FT proteins, but also similar to ORF4|X82447|OCCOXMSL4_4 FT Protein of coxMSL gene cluster from Pseudomonas/Oligotropha FT carboxidovorans (295 aa), FASTA scores: opt: 851, E(): 0, FT (48.2% identity in 282 aa overlap); AJ224684|BJAJ4684_3 FT cooxS from Bradyrhizobium japonicum (302 aa), FASTA scores: FT opt: 881, E(): 0, (47.6% identity in 290 aa overlap). Also FT highly similar to MTCY428_21 from Mycobacterium FT tuberculosis. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). TBparse score is 0.921." FT /db_xref="GOA:O53705" FT /db_xref="InterPro:IPR019825" FT /db_xref="UniProtKB/TrEMBL:O53705" FT /protein_id="CAA17376.1" FT /translation="MTFASPDDVIRRFDEQNYLLDTGTASAIYLAVTLGRPLLLEGEPG FT VGKTTAAKTLAVVLDTTLIRLQCYEGLTANEALYDWNYQRQLLSIRLAEARGKGISDIS FT EADLYTEAYLVDRPILRCVRHRGPTPPVLLIDEIDRADDEFEALLLEFLGESAVTVPEL FT GTFLAECPPIAVLTSNRSRDLHDALRRRCLYHWIDYPGPDRAAAIVRRTVPGATAPLIE FT NATQFVCTARDLDLDKPPGVAETIDWVAALVALGVADLTAADSSPALASLGALAKTPDD FT RTQIRDAYQAFTECSHA" FT misc_feature complement(105990..106013) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(106133..106726) FT /transl_table=11 FT /locus_tag="Rv0371c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0371c, (MTV036.06c), len: 197 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824 FT hypothetical protein from Streptomyces coelicolor (207 aa), FT FASTA scores: opt: 247, E(): 4.5e-09, (32.3% identity in FT 195 aa overlap). Also weak similarity with FT YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE FT from Bacillus subtilis (197 aa), FASTA scores: opt: 217, FT E(): 2.5e-08, (27.0% identity in 174 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O53706" FT /protein_id="CAA17377.1" FT /translation="MTATQITGVVLAAGRSNRLGTPKQLLPYRDTTVLGATLDVARQAG FT FDQLILTLGGAASAVRAAMALDGTDVVVVEDVERGCAASLRVALARVHPRATGIVLMLG FT DQPQVAPATLRRIIDVGPATEIMVCRYADGVGHPFWFSRTVFGELARLHGDKGVWKLVH FT SGRHPVRELAVDGCVPLDVDTWDDYRRLLESVPS" FT CDS complement(106723..107478) FT /transl_table=11 FT /locus_tag="Rv0372c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0372c, (MTV036.07c), len: 251 aa. Conserved FT hypothetical protein, showing some similarity with FT CAB76248.1|X82447|COXF CoxF protein from FT Pseudomonas/Oligotropha carboxidovorans (280 aa); FT AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum FT (176 aa), FASTA scores: opt: 186, E(): 1.6e-05, (41.1% FT identity in 95 aa overlap). Also similar to upstream ORF FT Rv0376c from Mycobacterium tuberculosis (380 aa), FASTA FT scores: E(): 6.8e-07, (31.0% identity in 277 aa overlap). FT TBparse score is 0.862." FT /db_xref="InterPro:IPR003777" FT /db_xref="UniProtKB/TrEMBL:O53707" FT /protein_id="CAA17378.1" FT /translation="MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGTI FT EGFVGGHCAQNSVRKAAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGSLE FT IFLTPQLPAPLIQIYGETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASHGGP FT EAEIIRTALDNGVGYVGLVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTPAEIA FT VSIAAELIATLRGGGPRGRKALADENGGA" FT CDS complement(107497..109896) FT /transl_table=11 FT /locus_tag="Rv0373c" FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (LARGE FT CHAIN)" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM [CATALYTIC ACTIVITY: CO + H(2)O + acceptor = FT CO(2) + reduced acceptor]." FT /EC_number="1.2.99.2" FT /note="Rv0373c, (MTV036.08c), len: 799 aa. Probable carbon FT monoxide dehydrogenase, large chain (EC 1.2.99.2), highly FT similar to others e.g. AAD00363.1| U80806|CUTL carbon FT monoxide dehydrogenase large subunit CutL protein from FT Hydrogenophaga pseudoflava (803 aa); FT S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA FT carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) FT (cut operon) from Pseudomonas thermocarboxydovorans (842 FT aa); C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL FT carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) FT (cluster coxMSL) from Pseudomonas/Oligotropha FT carboxydovorans (809 aa), FASTA scores: opt: 2484, E(): 0, FT (56.0% identity in 804 aa overlap); etc." FT /db_xref="GOA:O53708" FT /db_xref="HSSP:1FFV" FT /db_xref="InterPro:IPR012780" FT /db_xref="UniProtKB/TrEMBL:O53708" FT /protein_id="CAA17379.1" FT /translation="MTTIESRPPSPEDLADNAQQPCGHGRMMRKEDPRFIRGRGTYVDD FT VALPGMLHLAILRSPYAHARIVRIDVTAAQAHPKVKAVVTGADLAAKGLAWMPTLANDV FT QAVLATDKTRFQGQEVAFVVAEDRYSARDACELVDVDYEPRDPVVDARTALDPSAPVIR FT TDLEGKSDNHIFDWETGDAAATEAVFAKADVVVQQEIVYPRVHPAPMETCGAVADLDPV FT TGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKVPIYPGYVCAIVAS FT LLLDKPVKWMEDRSENLTSTGFARDYIMVGEIAANRDGKILAIRSNVLADHGAFNAQAA FT PAKYPAGFFGVFTGSYDIEAAYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCL FT AFELKMDPAELRLRNLLRPNQFPYQSKTGWVYDSGDYETTMRKAMNMIGYEALRAEQKQ FT RRARGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVLRLSVQTQGQ FT GHETTFAQIVAEELGIAPDDIEVVHGDTDQTPFGLGTYGSRSTPVSGGAAALVARKVRD FT KAKIIASGMLEVSVADLQWEKGKFHVKGDPSAAVTIADIAMRAHGAGDLPEGIEGGLDA FT EVCYNPSNLTYPYGAYFCVVDIDPGTAVVKVRRFLAVDDCGTRINPMIIEGQVHGGIVD FT GIGMALMEMIAFDEDGNCLGGSLMDYLIPTALEVPHLETGHTVTPSPHHPIGAKGIGES FT ATVGSPPAVVNAVVDALAPFGVRHADMPLTPSRVWEAMQGRATPPI" FT CDS complement(109893..110372) FT /transl_table=11 FT /locus_tag="Rv0374c" FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (SMALL FT CHAIN)" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM [CATALYTIC ACTIVITY: CO + H(2)O + acceptor = FT CO(2) + reduced acceptor]." FT /EC_number="1.2.99.2" FT /note="Rv0374c, (MTV036.09c), len: 159 aa. Probable carbon FT monoxide dehydrogenase, small chain (EC 1.2.99.2), highly FT similar to others e.g. FT B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide FT dehydrogenase small chain (EC 1.2.99.2) from FT Pseudomonas/Oligotropha carboxydovorans (166 aa), FASTA FT scores: opt: 662, E(): 0, (59.3% identity in 150 aa FT overlap); CAA12063.1|AJ224684 putative carbon monoxide FT dehydrogenase small subunit from Bradyrhizobium japonicum FT (161 aa); S49123|509390|CAA54901.1|X77931|CUTC FT carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) FT from Pseudomonas thermocarboxydovorans (163 aa); etc. FT TBparse score is 0.918." FT /db_xref="GOA:O53709" FT /db_xref="HSSP:1N62" FT /db_xref="InterPro:IPR002888" FT /db_xref="UniProtKB/TrEMBL:O53709" FT /protein_id="CAA17380.1" FT /translation="MQVNMTVNGEPVTAEVEPRMLLVHFLRDQLRLTGTHWGCDTSNCG FT TCVVEVDGVPVKSCTMLAVMASGHSIRTVEGLAGPDGQLDPVQEGFMRCHGLQCGFCTP FT GMLITARALLDRNPDPDEQTIREAISGQICRCTGYTTIVRSIQWAAAHQTVKAQS" FT CDS complement(110387..111247) FT /transl_table=11 FT /locus_tag="Rv0375c" FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM FT CHAIN)" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM [CATALYTIC ACTIVITY: CO + H(2)O + acceptor = FT CO(2) + reduced acceptor]." FT /EC_number="1.2.99.2" FT /note="Rv0375c, (MTV036.10c), len: 286 aa. Probable carbon FT monoxide dehydrogenase, medium chain (EC 1.2.99.2), similar FT to others e.g. AAD00361.1|U80806|CUTM carbon monoxide FT dehydrogenase middle subunit from Hydrogenophaga FT pseudoflava (287 aa); S49122|509389|CAA54900.1|X77931|CUTB FT carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) FT from Pseudomonas thermocarboxydovorans (287 aa); FT A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH FT carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) FT from Pseudomonas/Oligotropha carboxydovorans (288 aa), FT FASTA scores: opt: 594, E(): 0, (37.5% identity in 277 aa FT overlap); etc." FT /db_xref="GOA:O53710" FT /db_xref="HSSP:1N62" FT /db_xref="InterPro:IPR016169" FT /db_xref="UniProtKB/TrEMBL:O53710" FT /protein_id="CAA17381.1" FT /translation="MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEYLVDINDLA FT PELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIFRDAERVIADPVVRNRGTL FT GGSLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAIDDFLVGPYETALAHNEVLIEVR FT IPLRHNTSSAYAKVERRVGDWAITAAGAAVTLDGQTILAARVGLTAVNPDPVALAELSA FT GLVGQPATEEVFAEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGRVLGAP FT AAPEA" FT CDS complement(111323..112465) FT /transl_table=11 FT /locus_tag="Rv0376c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0376c, (MTV036.11c), len: 380 aa. Conserved FT hypothetical protein, highly similar to FT T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical FT protein from Streptomyces coelicolor (395 aa); and FT AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from FT Arthrobacter nicotinovorans (377 aa). And similar to other FT conserved hypothetical proteins e.g. FT NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical FT protein from Mesorhizobium loti (245 aa). Note that FT C-terminus shows similarity with C-termini of FT CAB76248.1|X82447|COXF CoxF protein from FT Pseudomonas/Oligotropha carboxidovorans (280 aa); FT CAB76250.1|X82447|COXI CoxI protein from FT Pseudomonas/Oligotropha carboxidovorans (330 aa); and FT AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum FT (176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in FT 138 aa overlap). Also some partial similarity with FT AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum FT (107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3% FT identity in 92 aa overlap); E1184330|Z99120|YURF YURF FT PROTEIN from Bacillus subtilis (330 aa), FASTA scores: opt: FT 170, E(): 2.9e- 16, (27.5% identity in 345 aa overlap). FT Also similar to downstream ORF Rv0372c from Mycobacterium FT tuberculosis (251 aa), FASTA scores: E(): 2.1e-06, (30.7% FT identity in 277 aa overlap)." FT /db_xref="InterPro:IPR003777" FT /db_xref="UniProtKB/TrEMBL:O53711" FT /protein_id="CAA17382.1" FT /translation="MAIWAAGDTAGVATVVRTLRSAPRPPGAAMVVAPDGSVSGSVSGG FT CVEGAVYELAAEVAQTGIPRLEHYGVSDDTAFAVGLTCGGIIDVFVEPVSRATFPELGE FT LADDIGAQRPVAIATVIAHPDERRVGRRLVIRPDTKSPVTGSLGSARADAAVIDDARGL FT LAVGRSEILEYGPDGQRRGEGMEVFVSSHAPRPRMLVFGAIDFAAALARQGSFLGYRVT FT VCDARAVFATPARFPTADDVVVAWPHRYLAAQAEAGGIDERTVICVLTHDPKFDVPVLE FT VALRLGVGYVGAMGSRKTHDDRMDRLRAAGLTDAELSRLSSPIGLDLGARTPEETAVSI FT AADIIARRWGGGGRPLADIAGRIHHDAQVAGEFKDYLTRH" FT CDS 112514..113479 FT /transl_table=11 FT /locus_tag="Rv0377" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LYSR-FAMILY)" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0377, (MTV036.12), len: 321 aa. Probable FT transcription regulator, lysR family, showing similarity FT with many hypothetical transcriptional regulators lysR FT homolog e.g. P32484|YEIE_ECOLI|M89774 HYPOTHETICAL FT TRANSCRIPTIONAL REGULATOR from Escherichia coli (293 aa), FT FASTA scores: opt: 265, E(): 4.9e-11, (28.6% identity in FT 266 aa overlap). Also similar to Rv2282c from Mycobacterium FT tuberculosis. Contains PS00044 bacterial regulatory protein FT lysR family signature. SEEMS TO BELONG TO THE LYSR FAMILY FT OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.903." FT /db_xref="GOA:O53712" FT /db_xref="InterPro:IPR005119" FT /db_xref="UniProtKB/Swiss-Prot:O53712" FT /protein_id="CAA17383.1" FT /translation="MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMHVAALRKELDD FT PLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTAIEVTEAAHGRRLLRIAASSAFAEHA FT APGLIELFSSRADDLSVELSVHPTSRFRELICSRAVDIAIGPASESSIGSDGSIFLRPF FT LKYQIITVVAPNSPLAAGIPMPALLRHQQWMLGPSAGSVDGEIATMLRGLAIPESQQRI FT FQSDAAALEEVMRVGGATLAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLAPSARQ FT PAVSELVGFISTPRCIQAMIPGSGVGVTRFRPKVHVTLWS" FT misc_feature 112562..112654 FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS 113730..113951 FT /transl_table=11 FT /locus_tag="Rv0378" FT /product="CONSERVED HYPOTHETICAL GLYCINE RICH PROTEIN" FT /function="UNKNOWN" FT /note="Rv0378, (MTV036.13), len: 73 aa. Conserved FT hypothetical gly-rich protein, showing some similarity to FT Mycobacterium tuberculosis PE_PGRS family; also similar to FT MTCY06H11_16|Z85982 hypothetical glycine-rich 88.5 KD FT protein (1011 aa), FASTA scores: opt: 237, E(): 0.0032, FT (58.7% identity in 63 aa overlap); MTV043_25. TBparse score FT is 0.860." FT /db_xref="UniProtKB/TrEMBL:O53713" FT /protein_id="CAA17384.1" FT /translation="MSGRWEAGNADGNGGSAGLIGSGGAGGDGGSGGATGAGGEGGDAG FT ASGSINGNAGDPGNSGERGAVGKPGAPG" FT CDS 114070..114285 FT /transl_table=11 FT /gene="secE2" FT /locus_tag="Rv0379" FT /product="POSSIBLE PROTEIN TRANSPORT PROTEIN SECE2" FT /function="THOUGHT TO BE INVOLVED IN PROTEIN TRANSPORT FT (EXPORT)." FT /note="Rv0379, (MTV036.14), len: 71 aa. Possible secE2, FT protein transport protein, showing similarity with FT P27340|S61G_SULSO|SECE PREPROTEIN TRANSLOCASE SECE SUBUNIT FT (PROTEIN TRANSPORT PROTEIN SEC61 GAMMA SUBUNIT HOMOLOG) FT from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt: FT 79, E(): 4.7. (30.3% identity in 66 aa overlap); and FT hypothetical proteins e.g. Q9HPW4|VNG1446H HYPOTHETICAL FT PROTEIN from Halobacterium sp. strain NRC-1 (77 aa); FT Q9I794|PA0038 HYPOTHETICAL PROTEIN from Pseudomonas FT aeruginosa (71 aa); etc. Also highly similar to FT U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis FT protein from a patient isolate (116 aa), FASTA scores: opt: FT 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap). Note FT that for Rv0379|MTV036.14, a translation initiation region FT different to the one in U85467|MTU85467_1 was chosen. COULD FT BE A PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION FT APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, FT SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732." FT /db_xref="InterPro:IPR009923" FT /db_xref="UniProtKB/TrEMBL:Q6MX43" FT /protein_id="CAE55277.1" FT /translation="MSVYKVIDIIGTSPTSWEQAAAEAVQRARDSVDDIRVARVIEQDM FT AVDSAGKITYRIKLEVSFKMRPAQPR" FT CDS complement(114361..114912) FT /transl_table=11 FT /locus_tag="Rv0380c" FT /product="POSSIBLE RNA METHYLTRANSFERASE (RNA METHYLASE)" FT /function="POSSIBLY CAUSES METHYLATION OF RNA." FT /EC_number="2.1.1.-" FT /note="Rv0380c, (MTV036.15c), len: 183 aa. Possible RNA FT methyltransferase (EC 2.1.1.-), equivalent to FT CAC32002.1|AL583925 possible RNA methyltransferase from FT Mycobacterium leprae (182 aa). Also some similarity with FT others methyltransferases e.g. FT P19396|TRMH_ECOLI|78514|JV0043 TRNA FT (GUANOSINE-2'-O-)-METHYLTRANSFERASE (TRNA FT METHYLTRANSFERASE) from Escherichia coli (229 aa), FASTA FT scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa FT overlap). Also similar to Rv0881, Rv3579c, Rv1644 from FT Mycobacterium tuberculosis." FT /db_xref="GOA:O53715" FT /db_xref="InterPro:IPR001537" FT /db_xref="UniProtKB/TrEMBL:O53715" FT /protein_id="CAA17386.1" FT /translation="MLLRDGDARNVVDAYRYWTREAIIADIDTRRHPLHVAIENFGHDA FT NIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRLCHHDSTTGLLEFAAGAGLTV FT VAVDNVPGAARLEQTALPRECLLLFGQEGPGITDDARAGAAVTVSIAQFGSTRSINAGV FT AAGIAMHAWIRQHADLGRAW" FT CDS complement(115008..115916) FT /transl_table=11 FT /locus_tag="Rv0381c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0381c, (MTV036.16c), len: 302 aa. Hypothetical FT unknown protein. Equivalent to AAK44616.1 from FT Mycobacterium tuberculosis strain CDC1551 (254 aa) but FT longer 48 aa. TBparse score is 0.902." FT /db_xref="UniProtKB/TrEMBL:O53716" FT /protein_id="CAA17387.1" FT /translation="MRILVAWATCGAVVLSGLTGCSGSSHSGRTYGAQSARTGESLAVL FT GWNMSVSNLRWSGDYVLIDVDASPTDPHAPHAKPEDIRFGLYGALAHPMESAALGSCGD FT AMAHVRDVVSPLSAPAGRLTGTVCLGPLKERSAVRGVYTYSPRDRIPGTAAAYPAAFPV FT GMLPTNQNDAGLVVKTTSVSAWRADGMQLGKPQLGDPVAFTGNGYMLLGLEVDAVPDRY FT RDDSAARGGPMMLLAAPTLPGRGLSPACATYGSSVLILPDALLDAVHISASLCTQGEIN FT EALLYATVATVGTHAALWTSR" FT CDS complement(115934..116473) FT /transl_table=11 FT /gene="pyrE" FT /locus_tag="Rv0382c" FT /standard_name="umpA" FT /product="PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE FT (OPRT) (OPRTASE)" FT /function="INVOLVED IN PYRIMIDINE BIOSYNTHESIS (AT THE FT FIFTH STEP) [CATALYTIC ACTIVITY: Orotidine 5'-phosphate + FT diphosphate = orotate + 5-phospho-alpha-D-ribose FT 1-diphosphate]." FT /EC_number="2.4.2.10" FT /note="Rv0382c, (MTV036.17c), len: 179 aa. Probable pyrE, FT orotate phosphoribosyltransferase (EC 2.4.2.10), equivalent FT to CAC32004.1|AL583925 probable purine/pyrimidine FT phosphoribosyltransferase from Mycobacterium leprae (179 FT aa). Also highly similar to many others e.g. FT T36540|4753874|CAB42037.1|AL049754|SCH10.28c probable FT orotate phosphoribosyltransferase from Streptomyces FT coelicolor (182 aa); FT H69115|2622996|AAB86326.1|AE000938_10|MTH1860 probable FT orotate phosphoribosyltransferase from Methanobacterium FT thermoautotrophicum (180 aa), FASTA scores: opt: 389, E(): FT 2.7e-20, (40.7% identity in 172 aa overlap); FT O08359|PYRE_SULAC|2065444|CAA73352.1|Y12822 OROTATE FT PHOSPHORIBOSYLTRANSFERASE from Sulfolobus acidocaldarius FT (197 aa); etc. Note that also similar to other puridine FT 5'-monophosphate synthases (umpA genes; UMP synthases), FT generally in N-terminus that corresponds to orotate FT phosphoribosyltransferase activity. Contains PS00589 PTS FT HPR component serine phosphorylation site signature. FT BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FT FAMILY. Note that previously known as umpA." FT /db_xref="GOA:P0A5U0" FT /db_xref="InterPro:IPR000836" FT /db_xref="UniProtKB/Swiss-Prot:P0A5U0" FT /protein_id="CAE55278.1" FT /translation="MAGPDRAELAELVRRLSVVHGRVTLSSGREADYYVDLRRATLHHR FT ASALIGRLMRELTADWDYSVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKAHGMQR FT LIEGSEVTGQRVLVVEDTSTTGNSALTAVHAVQDVGGEVVGVATVVDRATGAAEAIEAE FT GLRYRSVLGLADLGLD" FT misc_feature complement(115943..115990) FT /note="PS00589 PTS HPR component serine phosphorylation FT site signature" FT CDS complement(116554..117408) FT /transl_table=11 FT /locus_tag="Rv0383c" FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0383c, (MTV036.18c), len: 284 aa. Possible FT conserved secreted protein, with hydrophobic stretch in FT N-terminus and Pro-rich C-terminus. Equivalent to FT CAC32006.1|AL583925 possible secreted protein from FT Mycobacterium leprae (286 aa). TBparse score is 0.900." FT /db_xref="UniProtKB/TrEMBL:O53718" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17389.1" FT /translation="MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFDY FT ERESTEILKRWTRGVMSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGTNV FT VVDLRLKGLKEPRESDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAEIMW FT NEQNWTLVSMPIASTRAQWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAAPGRP FT VAPGGPAELPPRRAQPDPATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNGQQATN FT YQH" FT CDS complement(117549..120095) FT /transl_table=11 FT /gene="clpB" FT /locus_tag="Rv0384c" FT /standard_name="htpM" FT /product="PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN FT B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1)" FT /function="THOUGHT TO BE AN ATPASE SUBUNIT OF AN FT INTRACELLULAR ATP-DEPENDENT PROTEASE. SEEMS TO BE REGULATED FT POSITIVELY BY SIGH (Rv3223c PRODUCT) AND NEGATIVELY BY HSPR FT (Rv0353 PRODUCT)." FT /EC_number="3.-.-.-" FT /note="Rv0384c, (MTV036.19c), len: 848 aa. Probable clpB FT (alternate gene name: htpM), endopeptidase ATP-binding FT protein, chain B (EC 3.-.-.-), equivalent to FT AC32007.1|AL583925 heat shock protein from Mycobacterium FT leprae (848 aa). Also highly similar to others e.g. FT P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 CLPB FT PROTEIN (heat-inducible expression) from Corynebacterium FT glutamicum (852 aa), FASTA scores: opt: 4113, E(): 0, FT (74.5% identity in 846 aa overlap); FT T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c FT probable ATP-dependent proteinase ATP-binding chain from FT Streptomyces coelicolor (853 aa); FT P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB PROTEIN FT (HEAT SHOCK PROTEIN F84.1) from Escherichia coli strains FT K12 and O157:H7 (857 aa); etc. Also similar to Rv3596c|ClpC FT from Mycobacterium tuberculosis. Contains PS00870 and FT PS00871 Chaperonins clpA/B signatures and two PS000017 FT ATP/GTP-binding site motives A (P-loop). BELONGS TO THE FT CLPA/CLPB FAMILY. Contains probable coiled-coil domain from FT aa 411-503." FT /db_xref="GOA:P63288" FT /db_xref="HSSP:1JBK" FT /db_xref="InterPro:IPR004176" FT /db_xref="UniProtKB/Swiss-Prot:P63288" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17390.1" FT /translation="MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDGI FT AAPLLEAVGVEPATVRAETQRLLDRLPQATGASTQPQLSRESLAAITTAQQLATELDDE FT YVSTEHVMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQALQK FT YSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQR FT IVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELH FT TIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEYRKHIEKDAALERRFQQVYVG FT EPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAA FT SRLRMEIDSRPVEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAE FT LTTRWQNEKNAIEIVRDLKEQLEALRGESERAERDGDLAKAAELRYGRIPEVEKKLDAA FT LPQAQAREQVMLKEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMEDELGKRVIGQK FT AAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFLFDDERAMVRID FT MSEYGEKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQ FT VLDEGRLTDGHGRTVDFRNTILILTSNLGSGGSAEQVLAAVRATFKPEFINRLDDVLIF FT EGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGFDPVYGARPLRRLVQ FT QAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSLILG" FT misc_feature complement(118143..118199) FT /note="PS00871 Chaperonins clpA/B signature 2" FT misc_feature complement(118254..118277) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(119175..119213) FT /note="PS00870 Chaperonins clpA/B signature 1" FT misc_feature complement(119457..119480) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 120228..121400 FT /transl_table=11 FT /locus_tag="Rv0385" FT /product="PROBABLE MONOOXYGENASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0385, (MTV036.20), len: 390 aa. Probable FT monooxygenase (EC 1.-.-.-), similar to FT T37003|5738846|CAB52917.1|AL109949 probable FT flavohemoprotein from Streptomyces coelicolor (435 aa); and FT similar in part (C-termini) to various monooxygenases e.g. FT P19734|DMPP_PSESP|94993|F37831 PHENOL HYDROXYLASE P5 FT PROTEIN (PHENOL 2-MONOOXYGENASE P5 COMPONENT) (EC FT 1.14.13.7) from Pseudomonas putida (353 aa), FASTA scores: FT opt: 363, E(): 4.2e-16, (31.8% identity in 255 aa overlap); FT S47292|2120861|pir|S70085 phenol 2-monooxygenase (EC FT 1.14.13.7) chain mopP from Acinetobacter calcoaceticus (350 FT aa); P21394|XYLA_PSEPU|94933|B37316 XYLENE MONOOXYGENASE FT ELECTRON TRANSFER COMPONENT (EC 1.18.1.3) [INCLUDES: FT FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE] from Pseudomonas FT putida plasmid pWW0 (350 aa); FT AAC38360.1|AF043544|NtnMA|ntnA reductase component of FT 4-nitrotoluene monooxygenase from Pseudomonas sp. (328 aa); FT etc. TBparse score is 0.898." FT /db_xref="GOA:Q7ARS9" FT /db_xref="InterPro:IPR017927" FT /db_xref="UniProtKB/TrEMBL:Q7ARS9" FT /protein_id="CAA17391.1" FT /translation="MGLEDRDALRVLQNAFKLDDPELVRRFYAHWFALDASVRDLFPPD FT MGAQRAAFGQALHWVYGELVAQRAEEPVAFLAQLGRDHRKYGVLPTQYDTLRRALYTTL FT RDYLGHPSRGAWTDAVDEAAGQSLNLIIGVMSGAADADDAPAWWDGTVVEHIRVSRDLA FT VARLQLDRPLHYYPGQYVNVHVPQCPRRWRYLSPAIPADPNGRIEFHVRVVPGGLVSNA FT IVGETRPGDRWRLSGPHGAFRVDRDGGDVLMVAGSTGLAPLRALIIDLSRFAVNPRVHL FT FFGARYACELYDLPTLWQIAAHNPWLSVSPVSEYNGDPAWAADYPDVSAPRGLHVRQTG FT RLPDVVSRYGGWGDRQILICGGPAMVRATKAALIAKGAPPERIQHDPLSR" FT CDS 121504..124761 FT /transl_table=11 FT /locus_tag="Rv0386" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LUXR/UHPA-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0386, (MTV036.21), len: 1085 aa. Probable FT regulatory protein, LuxR/uhpA family, highly similar to FT CAC30706.1|AL583923 possible transcriptional regulator from FT Mycobacterium leprae (1106 aa). Also similar in part to FT other regulatory proteins e.g. CAB95788.1|AL359949 putative FT multi-domain regulatory protein from Streptomyces FT coelicolor (780 aa); N-terminus of CAB92369.1|AL356612 FT putative AfsR-like regulatory protein from Streptomyces FT coelicolor (1114 aa); N-terminus of FT NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional FT regulator from Mesorhizobium loti (952 aa); FT AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces FT coelicolor (993 aa), FASTA scores: opt: 224, E() : 1.1e-06, FT (26.1% identity in 867 aa overlap); etc. Also similar to FT many putative Mycobacterium tuberculosis regulatory FT proteins e.g. AL0212|MTV008_44 (1137 aa), FASTA scores: FT opt: 3756, E(): 0, (56.7% identity in 1089 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop), FT PS00622 Bacterial regulatory proteins, luxR family FT signature and probable helix-turn-helix motif at aa FT 1042-1063 (Score 1025, +2.68 S D). BELONGS TO THE LUXR/UHPA FT FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is FT 0.910." FT /db_xref="GOA:O53720" FT /db_xref="HSSP:1JE8" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:O53720" FT /protein_id="CAA17392.1" FT /translation="MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSGV FT IAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALRDE FT GNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSRPER FT VMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVTLTGA FT GGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRSTTDTV FT LRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEVSYRVPS FT LSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAARLRSMTLD FT EIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAVFVGCFFVD FT DAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYALEKLSEAGE FT VDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNRENSDTEGALA FT LASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADKALLDIFVDAAA FT GMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAEAIDLARAVDDRW FT RLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCRWCLGYAQLMRGEL FT AAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARAAADAALEAAELGEY FT FAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQRAFNAQAALAGGDLS FT AARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAHKALACAAESGAHLDLP FT DVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYRSDYVQSVTALRDAMGEK FT DFDAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPTEIDVVRLVGEGLANKDIA FT TRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT" FT misc_feature 122164..122187 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 124624..124707 FT /note="PS00622 Bacterial regulatory proteins, luxR family FT signature" FT CDS complement(124765..125499) FT /transl_table=11 FT /locus_tag="Rv0387c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0387c, (MTV036.22c), len: 244 aa. Conserved FT hypothetical protein, showing some similarity to FT MTCI237.20c, and M17282|HUMEL20_1 Human elastin gene, exon FT 1, Elastin (687 aa), FASTA scores: opt: 193, E(): 0.35, FT (34.4% identity in 189 aa overlap). TBparse score is FT 0.915." FT /db_xref="UniProtKB/TrEMBL:O53721" FT /protein_id="CAA17393.1" FT /translation="MSLLPTLQSFLPPPFDAIPNPIEDLDVLVAAAVAVAAGSLGVSAA FT QLGEIYRHDVVDEAQKAPHCPAESDQTPAGAAGDGDLPEVGGRVTSPPQPPVAALTGYS FT ANIGGLSVPHSWNLPPAVRQVAAMFPGATPMYMTGSSDGSYAGLAAAGLAGTGLAGLAA FT RGGSAPTPAAAAPAGAGGAGPAATRPAAQQTPAVPAAAAGSAIPGLPPGLPPGVVANLA FT ATLAAIPGATIIVVPPSPNANQ" FT CDS complement(125552..126094) FT /transl_table=11 FT /gene="PPE9" FT /locus_tag="Rv0388c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0388c, (MTV036.23c), len: 180 aa. Member of the FT Mycobacterium tuberculosis PPE family, highly similar to FT others e.g. MTCY10G2_10|Z92539 from Mycobacterium FT tuberculosis (391 aa), FASTA scores: opt: 667, E(): 0, FT (58.3% identity in 180 aa overlap) but much shorter." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q6MX42" FT /protein_id="CAE55279.1" FT /translation="MDFGALPPEINSARIYSGPGSRPLMQAAAAWQRLANELTATAASY FT SSVISGLTGDDWLGPSALSMAAAAVPYVAWMRATAASAEQAAAQAVAAANAYESAYAAT FT VPPTVIAANRRTMLSLVQTNVFGQNTPAIATSETHYGEMWAHDILAMDGYAGASGAASQ FT LRRSPATGDHQRGRVAE" FT CDS 126428..127687 FT /transl_table=11 FT /gene="purT" FT /locus_tag="Rv0389" FT /product="PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FT FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) FT (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) FT (FORMATE-DEPENDENT GAR TRANSFORMYLASE)" FT /function="INVOLVED IN THIRD STEP (FIRST OF TWO FT TRANSFORMYLATION REACTIONS) IN DE NOVO PURINE BIOSYNTHESIS. FT THIS IS AN ALTERNATIVE ENZYME TO THE PURN|Rv0956 GAR FT TRANSFORMYLASE (5'-PHOSPHORIBOSYLGLYCINAMIDE FT FORMYLTRANSFERASE). CATALYZES TWO REACTIONS: THE FIRST ONE FT IS THE PRODUCTION OF BETA-FORMYL GLYCINAMIDE RIBONUCLEOTIDE FT (GAR) FROM FORMATE, ATP AND BETA GAR; THE SECOND, A SIDE FT REACTION, IS THE PRODUCTION OF ACETYL PHOSPHATE AND ADP FT FROM ACETATE AND ATP [CATALYTIC ACTIVITY: FORMATE + ATP + FT 5'-PHOSPHO-RIBOSYLGLYCINAMIDE = FT 5'-PHOSPHORIBOSYL-N-FORMYLGLYCINAMIDE + ADP + FT PYROPHOSPHATE]." FT /EC_number="2.1.2.-" FT /note="Rv0389, (MTCY04D9.01, MTV036.24), len: 419 aa. FT Probable purT, phosphoribosylglycinamide formyltransferase FT 2 (EC 2.1.2.-), similar to others e.g. FT P33221|PURT_ECOLI|B1849 phosphoribosylglycinamide FT formyltransferase 2 from Escherichia coli strain K-12 (391 FT aa), FASTA scores: opt: 481, E(): 1.3e-22, (40.1% identity FT in 379 aa overlap); etc. BELONGS TO THE PURK / PURT FAMILY. FT COFACTOR: MAGNESIUM." FT /db_xref="GOA:P95197" FT /db_xref="HSSP:1KJ8" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/TrEMBL:P95197" FT /protein_id="CAB06595.1" FT /translation="MIDGWTEEQHEPTVRHERPAAPQDVRRVMLLGSAEPSRELAIALQ FT GLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVTVTAAVSVDAL FT DAVEQADGECTELVPNARAVRCTADREGLRRLAADQLGLPTAPFWFVGSLGELQAVAVH FT AGFPLLVSPVAGVAGQGSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIE FT FLVTMIVVCSQGPNGPLIEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAARIVK FT ALGGRGVFGVELMINGDEVYFADVTVCPAGSAWVTVRSQRLSVFELQARAILGLAVDTL FT MISPGAARVINPDHTAGRAAVGAAPPADALTGALGVPESDVVIFGRGLGVALATAPEVA FT IARERAREVASRLNVPDSRE" FT CDS 127684..128106 FT /transl_table=11 FT /locus_tag="Rv0390" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0390, (MTCY04D9.02), len: 140 aa. Conserved FT hypothetical protein, equivalent to FT AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein FT from Mycobacterium leprae (147 aa), FASTA scores: opt: 778, FT E(): 0, (79.0% identity in 138 aa overlap). Also similar to FT hypothetical proteins from several Rickettsia species." FT /db_xref="InterPro:IPR001763" FT /db_xref="PDB:2FSX" FT /db_xref="UniProtKB/TrEMBL:P95198" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06596.1" FT /translation="MSYAGDITPLQAWEMLSDNPRAVLVDVRCEAEWRFVGVPDLSSLG FT REVVYVEWATSDGTHNDNFLAELRDRIPADADQHERPVIFLCRSGNRSIGAAEVATEAG FT ITPAYNVLDGFEGHLDAEGHRGATGWRAVGLPWRQG" FT CDS 128103..129323 FT /transl_table=11 FT /gene="metZ" FT /locus_tag="Rv0391" FT /product="PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ FT (OSH SULFHYDRYLASE)" FT /function="INVOLVED IN METHIONINE BIOSYNTHESIS. CONVERTS FT O-SUCCINYLHOMOSERINE INTO HOMOCYSTEINE." FT /EC_number="4.2.99.-" FT /note="Rv0391, (MTCY04D9.03), len: 406 aa. Probable metZ, FT O-succinylhomoserine sulfhydrylase (EC 4.2.99.-), FT equivalent, but shorter 20 aa in N-terminus, to FT AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from FT Mycobacterium leprae (426 aa). Also highly similar to FT others e.g. METZ_PSEAE|P55218 o-succinylhomoserine FT sulfhydrylase from Pseudomonas aeruginosa (403 aa), FASTA FT scores: opt: 1175, E(): 0, (47.2% identity in 392 aa FT overlap); etc. BELONGS TO THE TRANS-SULFURATION ENZYMES FT FAMILY. Could also be a cystathionine gamma-synthase (EC FT 4.2.99.9)." FT /db_xref="GOA:P95199" FT /db_xref="HSSP:1GC0" FT /db_xref="InterPro:IPR015422" FT /db_xref="UniProtKB/TrEMBL:P95199" FT /protein_id="CAB06597.1" FT /translation="MTDESSVRTPKALPDGVSQATVGVRGGMLRSGFEETAEAMYLTSG FT YVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVFTS FT LGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDDLSQWERALSVPTQAVF FT FETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGTKHID FT GQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAWVLLKGLETLAIRVQHSNASAQ FT RIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTVVTFALDCPEDVAKQRAFEVL FT DKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEDTDDLIA FT DIDRALS" FT CDS complement(129320..130732) FT /transl_table=11 FT /gene="ndhA" FT /locus_tag="Rv0392c" FT /product="PROBABLE MEMBRANE NADH DEHYDROGENASE NDHA" FT /function="TRANSFER OF ELECTRONS FROM NADH TO THE FT RESPIRATORY CHAIN. THE IMMEDIATE ELECTRON ACCEPTOR FOR THE FT ENZYME IS BELIEVED TO BE UBIQUINONE. DOES NOT COUPLE THE FT REDOX REACTION TO PROTON TRANSLOCATION [CATALYTIC ACTIVITY: FT NADH + acceptor = NAD+ + reduced acceptor]." FT /EC_number="1.6.99.3" FT /note="Rv0392c, (MTCY04D9.04c), len: 470 aa. Probable ndhA, FT membrane NADH dehydrogenase (EC 1.6.99.3), equivalent to FT many e.g. AF038423|AF038423_1 NADH dehydrogenase from FT Mycobacterium smegmatis (457 aa), FASTA scores: opt: 1991, FT E(): 0, (67.9% identity in 458 aa overlap); MLCB1788_3 NADH FT dehydrogenase from Mycobacterium leprae (466 aa), FASTA FT score: (62.5% identity in 467 aa overlap). Also similar to FT others from several organisms e.g. FT P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH FT DEHYDROGENASE from Escherichia coli (434 aa); and FT Rv0392c|ndhB from Mycobacterium tuberculosis. Has FT hydrophobic stretch in C-terminus. BELONGS TO THE NADH FT DEHYDROGENASE FAMILY." FT /db_xref="GOA:P95200" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:P95200" FT /protein_id="CAB06598.1" FT /translation="MTLSSGEPSAVGGRHRVVIIGSGFGGLNAAKALKRADVDITLISK FT TTTHLFQPLLYQVATGILSEGDIAPTTRLILRRQKNVRVLLGEVNAIDLKAQTVTSKLM FT DMTTVTPYDSLIVAAGAQQSYFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEVSTD FT HAERERRLTFVVVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAPAVLP FT PMGPKLGLKAQRRLEKMDVEVQLNAMVTAVDYKGITIKEKDGGERRIECACKVWAAGVA FT ASPLGKMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFVVGDLMFVPGVPGVAQGAIQG FT ARYATTVIKHMVKGNDDPANRKPFHYFNKGSMATISRHSAVAQVGKLEFAGYFAWLAWL FT VLHLVYLVGYRNRIAALFAWGISFMGRARGQMAITSQMIYARLVMTLMEQQAQGALAAA FT EQAEHAEQEAAG" FT CDS 130874..132199 FT /transl_table=11 FT /locus_tag="Rv0393" FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0393, (MTCY04D9.05), len: 441 aa. Member of FT Mycobacterium tuberculosis 13E12 repeat family of conserved FT proteins, similar to many e.g. Rv1148c, Rv1945, Rv3467, FT Rv0336|MTCY279_3 (503 aa), FASTA scores: E(): 0, (61.1% FT identity in 347 aa overlap)." FT /db_xref="GOA:P95201" FT /db_xref="InterPro:IPR003870" FT /db_xref="UniProtKB/TrEMBL:P95201" FT /protein_id="CAB06599.1" FT /translation="MAVGRCAIPRFDQAASGSAINGGQVHLSDGSTSPARQLPAPWPGD FT AGAAAEGRAGVCCRGNRLPHVSDVGVSHRFDHRPAGVGAGGCRAGAAGAGLAVDDPGQL FT AAAIDRIVAVADPDAVRQVRERARDREVSIWNSADGMGEVYAQLYATDAQALDARLNAL FT VATVCAGDPRSTDQRRADALGALAAGADRLACRCDNPDCAAEGRPVSAVVIHVVAEQAS FT VKGHGQAPAALLGGDGLIPAELVAELAKTAGLQPIPVPAGTEPGYRPSVKLAAFVRARD FT LTCRAPGCDRPATQCDLDHTIAFADGGATHAANLKCLCRLHHLLATFCGWRAQQLPDGT FT VIWTLPGNQTYVTTPGSALLFPALCTPTGDPPAPEPARADRRGQRTAMMPRRASTRTQN FT RAHCIAAERHRNHQARRIAQAAVIATETHGPPPDPDDDPPPF" FT CDS complement(132215..132934) FT /transl_table=11 FT /locus_tag="Rv0394c" FT /product="POSSIBLE SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0394c, (MTCY04D9.06c), len: 239 aa. Possible FT secreted protein, sharing no homology with other proteins. FT Has hydrophobic stretch at its N-terminus." FT /db_xref="UniProtKB/TrEMBL:P95202" FT /protein_id="CAB06600.1" FT /translation="MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETTT FT REICESVGGADTVLSRIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDDQK FT VEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVLAAL FT IQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLILPSG FT GSAPTGDHPTPHPSTSR" FT CDS 133033..133437 FT /transl_table=11 FT /locus_tag="Rv0395" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0395, (MTCY04D9.07), len: 134 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P95203" FT /protein_id="CAB06601.1" FT /translation="MDWMPLGDYETFRHWSGKPRAWGPQESGWRAWFGGKIVDGLCEVL FT DEHLAVRRRGVPAAIGCVPWLSSEAVAETLLALSVFCVVIDKGTSFPSRLRNPDKGFPN FT VALLRLRDMAPSEHGSRCSSARGRLCLSMS" FT CDS 133443..133835 FT /transl_table=11 FT /locus_tag="Rv0396" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0396, (MTCY04D9.08), len: 130 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P95204" FT /protein_id="CAB06602.1" FT /translation="MRALGWLREDRKPLLNAKLLVLGHLALNVYDPDNGYGEEVLDFEP FT RTVWWGSANWTVRAGSHLEVGFACDDPTLVEEATAFVADVIAFSEPIDTTCAGPEPNLV FT QVEFDDAAMAEAMEEMAEPDDDGEDW" FT CDS 133909..134277 FT /transl_table=11 FT /locus_tag="Rv0397" FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0397, (MTCY04D9.09), len: 122 aa. Part of 13E12 FT repeat family of conserved Mycobacterium tuberculosis FT proteins, similar to downstream Rv0393|Z84725|MTCY4D9_5 FT CONSERVED 13E12 REPEAT FAMILY PROTEIN (441 aa), FASTA FT scores: E(): 0, (87.7% identity in 122 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P95205" FT /protein_id="CAB06603.1" FT /translation="MLATFWGWRAQQLPDGTVIWTLPGDQTYVTTPGSALLFPALCTPT FT GDPPRPDPARADRRGQRTAMMPRRASTRAQNRAHYIAAERHRNHQARRIAHVVTQTATT FT APETNGPPPDPDDDPPPF" FT CDS complement(134772..135413) FT /transl_table=11 FT /locus_tag="Rv0398c" FT /product="POSSIBLE SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0398c, (MTCY04D9.10c), len: 213 aa. Possible FT secreted protein, sharing no homology with other proteins. FT Has potential signal sequence with hydrophobic stretch from FT aa 7-25." FT /db_xref="UniProtKB/TrEMBL:P95206" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06589.1" FT /translation="MGVIARVVGVAACGLSLAVLAAAPTAGAEPTGALPPMTSSGSGPV FT IGDGDAALRQRISQQLFSFGDPTVQEVDGSDAAQFITAAAAVADRDVASVFLPLQRVLG FT CQQNTAGSGAGFGARAYRRTDGQWGGAMLVVAKSTVSDVDALKACVKSGWRKATAGTPT FT SMCNNGWTYPPFADTRRGEEGYFVLLAGTASDFCSAPNANYRTTASSWPG" FT CDS complement(135420..136649) FT /transl_table=11 FT /gene="lpqK" FT /locus_tag="Rv0399c" FT /product="POSSIBLE CONSERVED LIPOPROTEIN LPQK" FT /function="UNKNOWN" FT /note="Rv0399c, (MTCY04D9.11c), len: 409 aa. Possible lpqK, FT conserved lipoprotein, showing some similarity to FT penicillin binding proteins and various peptidases e.g. FT DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase FT protein (406 aa), FASTA scores: opt: 348, E(): 5.6e-16, FT (29.2% identity in 301 aa overlap). Also similar to other FT Mycobacterium tuberculosis PBPs and esterases. Has possible FT N-terminal signal sequence and appropriately positioned FT prokaryotic lipoprotein lipid attachment site (PS00013)." FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:P95207" FT /protein_id="CAB06590.1" FT /translation="MPVLRRLGCSVLALGLLAGCAPPRTGPASSPTNNGAKADAVIRIV FT RDFMTQAHLKAVLVRVTVAGKEVVTRAVGDSMTGVPATTAMHFRNGAVAISYVATLLLK FT LVDEKKLRLDDKLSRWLPDFPHADRVTLGQLAQMTSGYPDYVLGNEAFDAELYANPFRQ FT WTTQELLDQISSRPLLYDPGTNWNYAHTNYLLLGLALEKAAGQDMPTLLQRKVLSPLGL FT TATANSDTPAIPEPALHAFTSERRAALKIPAGVPFYEESTFWNPSWTITHGAIQTTTIY FT DMEATAVGIGSGRLLSADSYKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLGIVISGH FT WLLQNPMFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQGNYRNQADILFRKIGAEVAP FT NDAPPMPPGR" FT CDS complement(136659..137846) FT /transl_table=11 FT /gene="fadE7" FT /locus_tag="Rv0400c" FT /product="ACYL-CoA DEHYDROGENASE FADE7" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv0400c, (MTCY04D9.12c), len: 395 aa. Probable FT fadE7, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT many e.g. CAC12923.1|AL445403 putative acyl CoA FT dehydrogenase from Streptomyces coelicolor (397 aa); FT G624219 GLUTARYL-CoA DEHYDROGENASE PRECURSOR (438 aa), FT FASTA scores: opt: 1161, E(): 0, (48.1% identity in 391 aa FT overlap); etc." FT /db_xref="GOA:P95208" FT /db_xref="HSSP:1JQI" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:P95208" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06591.1" FT /translation="MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVA FT AWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRSLV FT SVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARRDGP FT DWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITS FT ELVLDNVRLPADAMLPGATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQ FT FGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNNTREALK FT ICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR" FT CDS 137882..138253 FT /transl_table=11 FT /locus_tag="Rv0401" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0401, (MTCY04D9.14), len: 129 aa. Probable FT conserved transmembrane protein, equivalent to FT AL023514|MLCB4_9 putative integral membrane protein from FT Mycobacterium leprae (122 aa), FASTA scores: opt: 548, E(): FT 4.4e-32, (66.9% identity in 121 aa overlap)." FT /db_xref="GOA:P95210" FT /db_xref="UniProtKB/TrEMBL:P95210" FT /protein_id="CAB06592.1" FT /translation="MRPRRALAGLAADVVAVLVFCAVGRRSHAEGLSVTGLAATAWPFL FT TGTGIGWVLARGWRRPTALAPTGVIVWLCTIVVGMVLRKVSSAGVAASFVVVASAVTAV FT LLLGWRAAVALMAPHRADG" FT CDS complement(138448..141324) FT /transl_table=11 FT /gene="mmpL1" FT /locus_tag="Rv0402c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL1" FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /note="Rv0402c, (MTCY04D9.15c), len: 958 aa. Probable FT mmpL1, conserved transmembrane transport protein (see FT Tekaia et al., 1999), member of RND superfamily, highly FT similar to other Mycobacterial proteins e.g. FT YV34_MYCTU|Q11171 hypothetical 106.2 kDa membrane protein FT from Mycobacterium tuberculosis (968 aa), FASTA scores: FT opt: 3551, E(): 0, (55.4% identity in 933aa overlap); FT YV34_MYCLE|P54881 hypothetical 105.2 kDa protein from FT Mycobacterium leprae (959 aa), FASTA scores: opt: 3615, FT E(): 0, (55.5% identity in 941 aa overlap); etc. Highly FT similar to many other mycobacterial MmpL proteins from FT Mycobacterium tuberculosis and Mycobacterium leprae e.g. FT Rv0450c, Rv0676c, Rv0507, etc. BELONGS TO THE MMPL FAMILY." FT /db_xref="GOA:P95211" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/Swiss-Prot:P95211" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06593.1" FT /translation="MRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQSV FT ARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLVTK FT LSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQRIVD FT SVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIML FT LTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQEARATG FT QNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASL FT TLAPAIIAVASRFGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKY FT QTNYNERYYIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLRNPTDMLILDRIAK FT TVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIENLQNLKDRVADLSTLTDQL FT QRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFWRPLRSFTYWE FT RHCFDIPICWSMRSLLNSMDNVDKLTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQT FT VKDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAANNDDSFYLPPEAFQNPDFQRGLK FT LFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQAASIYLAGTSSTY FT KDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQ FT HILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKTGMIRAMAGTGRVVTI FT AGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMTPALATLLGRWFWWPRR FT VDRLARQPQVLGPRRTTALSAERAALLQ" FT CDS complement(141321..141749) FT /transl_table=11 FT /gene="mmpS1" FT /locus_tag="Rv0403c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS1" FT /function="UNKNOWN" FT /note="Rv0403c, (MTCY04D9.16c), len: 142 aa. Probable FT mmpS1, conserved membrane protein (see citation below), FT highly similar to other Mycobacterial proteins e.g. FT YV33_MYCLE|P54880 hypothetical 16.9 kDa protein from FT Mycobacterium leprae (154 aa), FASTA scores: opt: 458, E(): FT 1.6e-26, (46.9% identity in 143 aa overlap); FT YV33_MYCTU|Q11170 hypothetical 15 .9 kDa protein from FT Mycobacterium tuberculosis (147 aa), FASTA scores: opt: FT 362, E(): 1.1e-19, (42.1% identity in 140 aa overlap); etc. FT Also similar to other MmpS proteins from Mycobacterium FT tuberculosis e.g. Rv0677c, Rv0451c, etc. BELONGS TO THE FT MMPS FAMILY." FT /db_xref="GOA:P0A5K0" FT /db_xref="InterPro:IPR008693" FT /db_xref="UniProtKB/Swiss-Prot:P0A5K0" FT /protein_id="CAB06594.1" FT /translation="MFGVAKRFWIPMVIVIVVAVAAVTVSRLHSVFGSHQHAPDTGNLD FT PIIAFYPKHVLYEVFGPPGTVASINYLDADAQPHEVVNAAVPWSFTIVTTLTAVVANVV FT ARGDGASLGCRITVNEVIREERIVNAYHAHTSCLVKSA" FT CDS 142070..143827 FT /transl_table=11 FT /gene="fadD30" FT /locus_tag="Rv0404" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD30 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv0404, (MTCY04D9.17-MTCY22G10.00), len: 585 aa. FT Probable fadD30, fatty-acid-CoA synthetase (EC 6.2.1.-), FT similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA FT synthase from Mycobacterium bovis (582 aa); FT MASC_MYCLE|P54200 masc protein from Mycobacterium leprae FT (372 aa), FASTA scores: opt: 888, E(): 0, (44.2% identity FT in 342 aa overlap). Also similar to Y06J_MYCTU|Q10976 FT hypothetical 67.9 kDa protein (626 aa), FASTA scores: opt: FT 1463, E(): 0, (42.4% identity in 568 aa overlap)." FT /db_xref="GOA:P95213" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:P95213" FT /protein_id="CAB06604.1" FT /translation="MSVISTLRDRATTTPSDEAFVFMDYDTKTGDQIDRMTWSQLYSRV FT TAVSAYLISYGRHADRRRTAAISAPQGLDYVAGFLGALCAGWTPVPLPEPLGSLRDKRT FT GLAVLDCAADVVLTTSQAETRVRATIATHGASVTTPVIALDTLDEPSGDNCDLDSQLSD FT WSSYLQYTSGSTANPRGVVLSMRNVTENVDQIIRNYFRHEGGAPRLPSSVVSWLPLYHD FT MGLMVGLFIPLFVGCPVILTSPEAFIRKPARWMQLLAKHQAPFSAAPNFAFDLAVAKTS FT EEDMAGLDLGHVNTIINGAEQVQPNTITKFLRRFRPYNLMPAAVKPSYGMAEAVVYLAT FT TKAGSPPTSTEFDADSLARGHAELSTFETERATRLIRYHSDDKEPLLRIVDPDSNIELG FT PGRIGEIWIHGKNVSTGYHNADDALNRDKFQASIREASAGTPRSPWLRTGDLGFIVGDE FT FYIVGRMKDLIIQDGVNHYPDDIETTVKEFTGGRVAAFSVSDDGVEHLVIAAEVRTEHG FT PDKVTIMDFSTIKRLVVSALSKLHGLHVTDFLLVPPGALPKTTSGKISRAACAKQYGAN FT KLQRVATFP" FT CDS 143824..148032 FT /transl_table=11 FT /gene="pks6" FT /locus_tag="Rv0405" FT /product="PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6" FT /function="POLYKETIDE SYNTHASE POSSIBLY INVOLVED IN LIPID FT SYNTHESIS." FT /note="Rv0405, (MTCY22G10.01), len: 1402 aa. Probable pks6, FT membrane-bound polyketide synthase (see citation below), FT highly similar to others e.g. CAC29643.1|AL583917 putative FT polyketide synthase from Mycobacterium leprae (2103 aa); FT Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa), FT FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa FT overlap); etc. Contains PS00606 Beta-ketoacyl synthases FT active site, 2 x PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00012 Phosphopantetheine attachment site." FT /db_xref="GOA:O86335" FT /db_xref="HSSP:1MLA" FT /db_xref="InterPro:IPR018201" FT /db_xref="UniProtKB/TrEMBL:O86335" FT /protein_id="CAB06605.1" FT /translation="MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSID FT VLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGS FT INEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDV FT AGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDY FT VRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRS FT LSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVL FT QRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGY FT VEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVL FT MVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAH FT VIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDV FT VDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVF FT AGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQ FT PALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQA FT LPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRV FT HRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARH FT IRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVS FT VMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIG FT ASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADS FT GFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAE FT RIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVV FT ICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIID FT VVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFS FT PNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIA FT TVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPHR FT " FT misc_feature 144598..144648 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 144904..144927 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 145459..145482 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 146962..147009 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS complement(147980..148798) FT /transl_table=11 FT /locus_tag="Rv0406c" FT /product="BETA LACTAMASE LIKE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0406c, (MTCY22G10.02c), len: 272 aa. FT Beta-lactamase-like protein, equivalent to FT AAD38170.1|AF152397_1 beta-lactamase-like protein from FT Mycobacterium phlei (243 aa); AL023514|MLCB4_8 hypothetical FT protein from Mycobacterium leprae (251 aa), FASTA scores: FT opt: 1284, E(): 0, (74.9% identity in 243 aa overlap); and FT AAD38164.1|AF152394_2 beta-lactamase-like protein from FT Mycobacterium avium (247 aa), FASTA scores: opt: 1301, E(): FT 0, (74.2% identity in 244 aa overlap); etc. Also slight FT similarity to others beta-lactamases and hypothetical FT proteins e.g. P52700|BLA1_XANMA|628530|S45349 FT METALLO-BETA-LACTAMASE L1 PRECURSOR (BETA-LACTAMASE, TYPE FT II) (PENICILLINASE) from Xanthomonas maltophilia (290 aa), FT FASTA scores: (34.4% identity in 96 aa overlap)." FT /db_xref="GOA:O86336" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:O86336" FT /protein_id="CAB06606.1" FT /translation="MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLVT FT DDTGVLLIDAGYPGDRAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHSTP FT VYCHAEEVGHAKREYRENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQPLTA FT EAAAGLPGQPMAIFTPGHTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAVFSHS FT QQNSIRSLAALALLETNILAPGHGELWHGPIRKATDEALERAQKSNHVFR" FT CDS 148876..149886 FT /transl_table=11 FT /gene="fgd1" FT /locus_tag="Rv0407" FT /standard_name="fgd" FT /product="PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE FT DEHYDROGENASE FGD1" FT /function="CATALYZES OXIDATION OF GLUCOSE-6-PHOSPHATE TO FT 6-PHOSPHOGLUCONOLACTONE USING COENZYME F420 (AN FT *-HYDROXY-5-DEAZAFLAVIN DERIVATIVE) AS THE ELECTRON FT ACCEPTOR." FT /EC_number="1.-.-.-" FT /note="Rv0407, (MTCY22G10.03), len: 336 aa. Probable fgd1, FT F420-dependent glucose-6-phosphate dehydrogenase (EC FT 1.-.-.-), equivalent to others from Mycobacteria e.g. FT AAD38165.1|AF152394_3 from Mycobacterium avium (336 aa), FT FASTA scores: opt: 2082, E(): 0, (89.9% identity in 336 aa FT overlap); AL023514|MLCB 4_7 from Mycobacterium leprae (336 FT aa), FASTA scores: opt: 2069, E(): 0, (89.0% identity in FT 336 aa overlap). Also similar to other dehydrogenases e.g. FT CAA77276.1|Y18730 F420-dependent alcohol dehydrogenase from FT Methanofollis liminatans (330 aa). Also similar to many FT proteins from Mycobacterium tuberculosis e.g. Rv0953c, FT Rv0791c, etc. Note that previously known as fgd." FT /db_xref="GOA:P96253" FT /db_xref="InterPro:IPR019945" FT /db_xref="PDB:3B4Y" FT /db_xref="UniProtKB/TrEMBL:P96253" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06577.1" FT /translation="MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWR FT HQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVFLG FT VGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGASIY FT DVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAADRSV FT DGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIA FT KRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRRLG" FT CDS 149879..151951 FT /transl_table=11 FT /gene="pta" FT /locus_tag="Rv0408" FT /product="PROBABLE PHOSPHATE ACETYLTRANSFERASE PTA FT (PHOSPHOTRANSACETYLASE)" FT /function="INVOLVED AT THE LAST STEP (OF TWO) IN THE FT CONVERSION OF ACETATE TO ACETYL-CoA [CATALYTIC ACTIVITY: FT Acetyl-CoA + phosphate = CoA + acetyl phosphate]." FT /EC_number="2.3.1.8" FT /note="Rv0408, (MTCY22G10.04), len: 690 aa. Probable pta, FT phosphate acetyltransferase (EC 2.3.1.8), highly similar to FT others e.g. PTA_ECOLI|P39184|11279789|JX0357|B2297 FT phosphate acetyltransferase from Escherichia coli strain FT K12 (713 aa), FASTA scores: opt: 1303, E(): 0, (38.0% FT identity in 718 aa overlap); etc. BELONGS TO THE PHOSPHATE FT ACETYLTRANSFERASE AND BUTYRYLTRANSFERASE FAMILY." FT /db_xref="GOA:P96254" FT /db_xref="InterPro:IPR002505" FT /db_xref="UniProtKB/Swiss-Prot:P96254" FT /protein_id="CAB06578.1" FT /translation="MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITRL FT SAERDYILELLLAHTSAGLPYERCVGVTYQQLHADRDDAIAEIVDSYHAMADECDAVVV FT VGSDYTDVTSPTELSVNGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQRAH FT TAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVSGDVA FT LREREVMGVLAAGMTADHVLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVL FT NGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAASARGLVTATSQRKIDTALELM FT DRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRILKSAGRLL FT QRGIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQLRKAKGITV FT EHAREIMNDATYFGTMLVHNCHADGMVSGAAHTTAHTVRPALEIIKTVPGISTVSSIFL FT MCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPRVAMLSYSTGDSGKGAD FT VDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRATVLIFPDLNTG FT NNTYKAVQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITAIQAQGVHE" FT CDS 151944..153101 FT /transl_table=11 FT /gene="ackA" FT /locus_tag="Rv0409" FT /product="PROBABLE ACETATE KINASE ACKA (ACETOKINASE)" FT /function="INVOLVED AT THE FIRST STEP (OF TWO) IN THE FT CONVERSION OF ACETATE TO ACETYL-CoA [CATALYTIC ACTIVITY: FT ATP + acetate = ADP + acetyl phosphate]." FT /EC_number="2.7.2.1" FT /note="Rv0409, (MTCY22G10.05), len: 385 aa. Probable ackA, FT acetate kinase (EC 2.7.2.1), highly similar to others e.g. FT ACKA_BACSU|P37877 acetate kinase from Bacillus subtilis FT (395 aa), FASTA scores: opt: 974, E(): 0, (43.5% identity FT in 393 aa overlap); etc. Contains PS01075 Acetate and FT butyrate kinases family signature 1, PS00758 ArgE / dapE / FT ACY1/ CPG2 / yscS family signature 1. BELONGS TO THE FT ACETOKINASE FAMILY." FT /db_xref="GOA:P63409" FT /db_xref="HSSP:1G99" FT /db_xref="InterPro:IPR004372" FT /db_xref="UniProtKB/Swiss-Prot:P63409" FT /protein_id="CAB06579.1" FT /translation="MSSTVLVINSGSSSLKFQLVEPVAGMSRAAGIVERIGERSSPVAD FT HAQALHRAFKMLAEDGIDLQTCGLVAVGHRVVHGGTEFHQPTLLDDTVIGKLEELSALA FT PLHNPPAVLGIKVARRLLANVAHVAVFDTAFFHDLPPAAATYAIDRDVADRWHIRRYGF FT HGTSHQYVSERAAAFLGRPLDGLNQIVLHLGNGASASAIARGRPVETSMGLTPLEGLVM FT GTRSGDLDPGVISYLWRTARMGVEDIESMLNHRSGMLGLAGERDFRRLRLVIETGDRSA FT QLAYEVFIHRLRKYLGAYLAVLGHTDVVSFTAGIGENDAAVRRDALAGLQGLGIALDQD FT RNLGPGHGARRISSDDSPIAVLVVPTNEELAIARDCLRVLGGRRA" FT misc_feature 151956..151991 FT /note="PS01075 Acetate and butyrate kinases family FT signature 1" FT misc_feature 152841..152870 FT /note="PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family FT signature 1" FT CDS complement(153155..155407) FT /transl_table=11 FT /gene="pknG" FT /locus_tag="Rv0410c" FT /product="SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN FT KINASE G) (STPK G)" FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO REGULATE AMINO-ACID UPTAKE AND FT STATIONARY-PHASE METABOLISM. PHOSPHORYLATES THE PEPTIDE FT SUBSTRATE MYELIN BASIC PROTEIN (MBP) AT SERINE RESIDUES FT [CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A FT PHOSPHOPROTEIN]." FT /EC_number="2.7.1.-" FT /note="Rv0410c, (MTCY22G10.06c), len: 750 aa. pknG, FT serine/threonine-protein kinase (EC 2.7.1.-) (see citations FT below), equivalent to FT PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 PROBABLE FT SERINE/THREONINE-PROTEIN KINASE from Mycobacterium leprae FT (767 aa). Also similar to others e.g. AB76890.1|AL159139 FT putative serine/threonine protein kinase from Streptomyces FT coelicolor (774 aa); etc. Contains PS00108 Serine/Threonine FT protein kinases active-site signature. Contains Hank's FT kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN FT KINASES." FT /db_xref="GOA:P65728" FT /db_xref="InterPro:IPR011990" FT /db_xref="PDB:2PZI" FT /db_xref="UniProtKB/Swiss-Prot:P65728" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06580.1" FT /translation="MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDN FT FPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKR FT FCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLG FT WIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDR FT HGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPEN FT IMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTL FT DLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREV FT VAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLV FT DPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGD FT VAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLAL FT AATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRH FT FTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLK FT DNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF" FT misc_feature complement(154556..154594) FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT CDS complement(155407..156393) FT /transl_table=11 FT /gene="glnH" FT /locus_tag="Rv0411c" FT /product="PROBABLE GLUTAMINE-BINDING LIPOPROTEIN GLNH FT (GLNBP)" FT /function="INVOLVED IN ACTIVE TRANSPORT OF GLUTAMINE ACROSS FT THE MEMBRANE (IMPORT). INTERACTS WITH THE FT GLUTAMINE-TRANSPORT SYSTEM." FT /note="Rv0411c, (MTCY22G10.07c), len: 328 aa. Probable FT glnH, glutamine-binding protein, membrane-bound lipoprotein FT (see citation below), equivalent to FT AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 FT glutamine-binding protein homolog from Mycobacterium leprae FT (325 aa), FASTA scores: opt: 1747, E(): 0, (79.3% identity FT in 328 aa overlap). Also similar to others e.g. FT GLNH_BACST|P27676 glutamine-binding protein precursor from FT Bacillus stearothermophilus (262 aa), FASTA scores: opt: FT 493, E(): 7.5e-22, (37.8% identity in 193 aa overlap); etc. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site, PS01039 Bacterial extracellular FT solute-binding proteins, family 3 signature. BELONGS TO THE FT BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 3. FT Presumed attached to the membrane by a lipid anchor." FT /db_xref="GOA:P96257" FT /db_xref="InterPro:IPR001638" FT /db_xref="UniProtKB/TrEMBL:P96257" FT /protein_id="CAB06581.1" FT /translation="MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPTP FT VGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLIVGLDIGSNL FT FSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSAAERVTALQKSQVDIVVKTM FT SITCERRKLVNFSTVYLDANQRILAPRDSPITKVSDLSGKRVCVARGTTSLRRIREIAP FT PPVIVSVVNWADCLVALQQREIDAVSTDDTILAGLVEEDPYLHIVGPDMADQPYGVGIN FT LDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD" FT misc_feature complement(156004..156045) FT /note="PS01039 Bacterial extracellular solute-binding FT proteins, family 3 signature" FT misc_feature complement(156316..156348) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(156393..157712) FT /transl_table=11 FT /locus_tag="Rv0412c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0412c, (MTCY22G10.08c), len: 439 aa. Possible FT conserved membrane protein, equivalent to FT AL035159|MLCB1450_16|T44737 probable membrane protein from FT Mycobacterium leprae (403 aa), FASTA scores: opt: 2027, FT E(): 0, (80.4% identity in 403 aa overlap). Also some FT similarity with CAB71201.1|AL138538 putative secreted FT protein from Streptomyces coelicolor (429 aa)." FT /db_xref="UniProtKB/TrEMBL:P96258" FT /protein_id="CAB06582.1" FT /translation="MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLAA FT LGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAEPG FT GVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRAGNP FT VGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVVFGAF FT AHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLKTITNL FT AITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPDLQGADQ FT LLVRWRQANDRINSDISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMGQSRTQLR FT HDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR" FT CDS 157806..158459 FT /transl_table=11 FT /gene="mutT3" FT /locus_tag="Rv0413" FT /product="POSSIBLE MUTATOR PROTEIN MUTT3 FT (7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE) (8-OXO-DGTPASE) FT (DGTP PYROPHOSPHOHYDROLASE)" FT /function="POSSIBLY INVOLVED IN THE GO SYSTEM RESPONSIBLE FT FOR REMOVING AN OXIDATIVELY DAMAGED FORM OF GUANINE FT (7,8-DIHYDRO-8-OXOGUANINE) FROM DNA AND THE NUCLEOTIDE FT POOL. 8-OXO-DGTP IS INSERTED OPPOSITE DA AND DC RESIDUES OF FT TEMPLATE DNA WITH ALMOST EQUAL EFFICIENCY THUS LEADING TO FT A.T TO G.C TRANSVERSIONS. MUTT SPECIFICALLY DEGRADES FT 8-OXO-DGTP TO THE MONOPHOSPHATE [CATALYTIC ACTIVITY: FT 8-OXO-DGTP + H2O = 8-OXO-DGMP + PYROPHOSPHATE]." FT /EC_number="3.6.1.-" FT /note="Rv0413, (MTCY22G10.10), len: 217 aa. Possible mutT3, FT mutator protein (EC 3.6.1.-) (see citation below), showing FT some similarity with e.g. MUTT_PROVU|P32090 mutator mutt FT protein from Proteus vulgaris (112 aa), FASTA scores: opt: FT 151, E(): 0.0008, (40.7% identity in 59 aa overlap). SEEMS FT TO BELONG TO THE NUDIX HYDROLASE FAMILY." FT /db_xref="GOA:P96259" FT /db_xref="InterPro:IPR020084" FT /db_xref="UniProtKB/TrEMBL:P96259" FT /protein_id="CAB06583.1" FT /translation="MPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRPD FT GTPAVLLQHRALWSHQGGTWGLPGGARDSHETPEQTAVRESSEEAGLSAERLEVRATVV FT TAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAASWQR FT LRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL" FT CDS complement(158443..159111) FT /transl_table=11 FT /gene="thiE" FT /locus_tag="Rv0414c" FT /product="PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE FT THIE (TMP PYROPHOSPHORYLASE) (TMP-PPASE) FT (THIAMINE-PHOSPHATE SYNTHASE)" FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS. CONDENSES FT 4-METHYL-5-(BETA-HYDROXYETHYL)-THIAZOLE MONOPHOSPHATE FT (THZ-P) AND 4-AMINO-5-HYDROXYMETHYL PYRIMIDINE FT PYROPHOSPHATE (HMP-PP) TO FORM THIAMINE MONOPHOSPHATE (TMP) FT [CATALYTIC ACTIVITY: FT 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + FT 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + FT thiamine monophosphate]." FT /EC_number="2.5.1.3" FT /note="Rv0414c, (MTCY22G10.11c), len: 222 aa. Probable FT thiE, thiamin phosphate pyrophosphorylase (EC 2.5.1.3), FT equivalent to Q9ZBL5|AL035159|MLCB1450_17 PROBABLE FT THIAMINE-PHOSPHATE PYROPHOSPHORYLASE from Mycobacterium FT leprae (235 aa), FASTA scores: opt: 1095, E(): 0, (78.0% FT identity in 223 aa overlap). Also similar to others e.g. FT T34974|5689976|CAB52013.1|AL109663 probable thiamin FT phosphate pyrophosphorylase from Streptomyces coelicolor FT (223 aa); THIE_ECOLI|P30137 thie protein from Escherichia FT coli strain K12 (211 aa), FASTA scores: opt: 275, E(): FT 7.8e-12, (37.8% identity in 196 aa overlap); etc. BELONGS FT TO THE TMP-PPASE FAMILY." FT /db_xref="GOA:P66916" FT /db_xref="HSSP:1G4E" FT /db_xref="InterPro:IPR003733" FT /db_xref="UniProtKB/Swiss-Prot:P66916" FT /protein_id="CAB06584.1" FT /translation="MHESRLASARLYLCTDARRERGDLAQFAEAALAGGVDIIQLRDKG FT SPGELRFGPLQARDELAACEILADAAHRYGALFAVNDRADIARAAGADVLHLGQRDLPV FT NVARQILAPDTLIGRSTHDPDQVAAAAAGDADYFCVGPCWPTPTKPGRAAPGLGLVRVA FT AELGGDDKPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSALTAAN FT " FT CDS 159241..160263 FT /transl_table=11 FT /gene="thiO" FT /locus_tag="Rv0415" FT /product="POSSIBLE THIAMINE BIOSYNTHESIS OXIDOREDUCTASE FT THIO" FT /function="POSSIBLY INVOLVED IN THIAMINE BIOSYNTHESIS." FT /EC_number="1.-.-.-" FT /note="Rv0415, (MTCY22G10.12), len: 340 aa. Possible thiO, FT thiamine biosynthesis oxidoreductase (EC 1.-.-.-), FT equivalent to FT T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical FT protein from Mycobacterium leprae (340 aa), FASTA scores: FT opt: 1867, E(): 0, (82.0% identity in 338 aa overlap). FT Shows some similarity to other thiO proteins e.g. FT THIO_RHIET|O34292 Putative thiamine biosynthesis FT oxidoreductase from Rhizobium etli plasmid pb (327 aa) (see FT citation below); AAG31046.1|AF264948_8|THIO putative amino FT acid oxidase flavoprotein ThiO from Erwinia amylovora (349 FT aa); NP_106392.1|14025578|BAB52178.1|AP003007|THIO THIAMINE FT BIOSYNTHESIS OXIDOREDUCTASE THIO from Mesorhizobium loti FT (333 aa); etc." FT /db_xref="GOA:P96261" FT /db_xref="HSSP:1NG4" FT /db_xref="InterPro:IPR012727" FT /db_xref="UniProtKB/TrEMBL:P96261" FT /protein_id="CAB06585.1" FT /translation="MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSDERGASW FT VAGGMLAPHSEGWPGEERLLRLGLQSLRLWREGSFLDGLGPQLVTAHESLVVAVDRADV FT ADLRTVADWLSAQGHPVIWESAARDVEPLLAQGIRHGFRAPTELAVDNRALLDALCRDC FT ERLGVRWSSQVSSLSDVDAHTVVIANGIDAPALWPGLPIRPVKGEVLRLRWRPGCMPLP FT QRVIRARVRGRQVYLVPRSDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLPALGEY FT ELAECEAGLRPMTPDNLPLVQRLDSRTLVAAGHGRSGFLLAPWTAEQIVSELVSVGAAS FT " FT CDS 160260..160466 FT /transl_table=11 FT /gene="thiS" FT /locus_tag="Rv0416" FT /product="POSSIBLE PROTEIN THIS" FT /function="POSSIBLY INVOLVED IN THIAMINE BIOSYNTHESIS." FT /note="Rv0416, (MTCY22G10.13), len: 68 aa. Possible thiS FT protein, equivalent to FT T44740|4154055|CAA22709.1|AL035159|MLCB1450.25 hypothetical FT protein from Mycobacterium leprae (74 aa), FASTA scores: FT opt: 303, E(): 2e-18, (71.6% identity in 74 aa overlap). FT Shows weak similarity with O32583|THIS_ECOLI|THIG1|B3991.1 FT THIS PROTEIN from Escherichia coli strain K12 (66 aa), FT FASTA scores: opt: 103, E(): 0.052, (30.9% identity in 68 FT aa overlap)." FT /db_xref="GOA:P96262" FT /db_xref="InterPro:IPR012675" FT /db_xref="UniProtKB/TrEMBL:P96262" FT /protein_id="CAB06586.1" FT /translation="MIVVVNEQQVEVDEQTTIAALLDSLGFGDRGIAVALNFSVLPRSD FT WATKICELRKPVRLEVVTAVQGG" FT CDS 160459..161217 FT /transl_table=11 FT /gene="thiG" FT /locus_tag="Rv0417" FT /product="PROBABLE THIAMIN BIOSYNTHESIS PROTEIN THIG FT (THIAZOLE BIOSYNTHESIS PROTEIN)" FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS. Required for FT the synthesis of the thiazole moiety of thiamine." FT /note="Rv0417, (MTCY22G10.14), len: 252 aa. Probable thiG, FT thiamin biosynthesis protein, equivalent to FT AL035159|MLCB1450_20|T44741|THIG probable thiamin FT biosynthesis protein from Mycobacterium leprae (261 aa), FT FASTA scores: opt: 1380, E(): 0, (86.8% identity in 250 aa FT overlap). Also highly similar to others e.g. FT SCOEDB|SC6E10.03|T35490|THIG probable thiazole biosynthesis FT protein from Streptomyces coelicolor (264 aa); FT F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG thiamin FT biosynthesis protein thiG from Xylella fastidiosa (275 aa); FT P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089.1|U00006 FT THIG PROTEIN thiamin biosynthesis protein from Escherichia FT coli strain K-12 (281 aa); etc. BELONGS TO THE THIG FT FAMILY." FT /db_xref="GOA:P96263" FT /db_xref="InterPro:IPR008867" FT /db_xref="UniProtKB/Swiss-Prot:P96263" FT /protein_id="CAB06587.1" FT /translation="MAESKLVIGDRSFASRLIMGTGGATNLAVLEQALIASGTELTTVA FT IRRVDADGGTGLLDLLNRLGITPLPNTAGSRSAAEAVLTAQLAREALNTNWVKLEVIAD FT ERTLWPDAVELVRAAEQLVDDGFVVLPYTTDDPVLARRLEDTGCAAVMPLGSPIGTGLG FT IANPHNIEMIVAGARVPVVLDAGIGTASDAALAMELGCDAVLLASAVTRAADPPAMAAA FT MAAAVTAGYLARCAGRIPKRFWAQASSPAR" FT CDS 161589..163091 FT /transl_table=11 FT /gene="lpqL" FT /locus_tag="Rv0418" FT /product="PROBABLE LIPOPROTEIN AMINOPEPTIDASE LPQL" FT /function="UNKNOWN; HYDROLYZES PEPTIDES AND/OR PROTEINS." FT /EC_number="3.4.11.-" FT /note="Rv0418, (MTCCY22G10.15), len: 500 aa. Probable lpqL, FT lipoprotein aminopeptidase (EC 3.4.11.-), similar to others FT e.g. B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939 FT probable aminopeptidase from Pseudomonas aeruginosa (536 FT aa); P80561|APX_STRGR|SGAP|S66427 aminopeptidase (EC FT 3.4.11.-) from Streptomyces griseus (284 aa) (homology only FT with C-terminus of Rv0418); FT P37302|APE3_YEAST|1077010|A54134 aminopeptidase Y (EC FT 3.4.11.-) from Saccharomyces cerevisiae (537 aa); etc. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:P96264" FT /db_xref="HSSP:1CP7" FT /db_xref="InterPro:IPR007484" FT /db_xref="UniProtKB/TrEMBL:P96264" FT /protein_id="CAB06558.1" FT /translation="MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEFA FT VALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQTPE FT FSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDYDRL FT PVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIPVVSV FT TKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVPEGPGI FT NDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDALKGIAL FT YLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAGKTAQDTS FT FDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQKTDTLDHID FT RTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP" FT misc_feature 161631..161663 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 163179..164675 FT /transl_table=11 FT /gene="lpqM" FT /locus_tag="Rv0419" FT /product="POSSIBLE LIPOPROTEIN PEPTIDASE LPQM" FT /function="UNKNOWN; POSSIBLY HYDROLYZES PEPTIDES AND/OR FT PROTEINS." FT /EC_number="3.4.11.-" FT /note="Rv0419, (MTCY22G10.16), len: 498 aa. Possible lpqM, FT lipoprotein peptidase (EC 3.4.-.-); has potential FT N-terminal signal peptide and contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site, PS00142 Neutral FT zinc metallopeptidases, zinc-binding region signature." FT /db_xref="GOA:P96265" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:P96265" FT /protein_id="CAB06559.1" FT /translation="MHGRGRYRPLVRCVRPRRVAASVRTPIACLAAVVVIAGCTTVVDG FT RALSILNDPFRVGGLPATNGPSGARPDAPAASGTVINTNNGAIDKLSLLSVNDIEDYWM FT AVYSESLKGTFRPVGKLVSYDSNDPSSPIVCHIDTYQLVNAFFSSRCNLIAWDRGVFMA FT VAQEYFGDMSVNGVLAHEFGHALQVMANLVTRKDPTIVREQQADCFAGVYLWWVAEGKS FT TRFTLSTADGLDHVLAGIITTRDPVMEADAENDDEHGSALDRVSAFQLGFINGTPACAA FT IDEDEVERRRGDLPTALRVDASGNPETGEVGINEETLSTLMELMGKIFSPKNPPTLSYQ FT PAGCPDAKPSPPAAYCPATNTIVVDLPALARMGKVASAAEHSLPQGDDTSLSIVMSRYA FT LAVQHERGLPMQSPWTALRTACLTGVAHRKMAVPIDLPSGQQLVLTAGDLDEAVSGLLT FT NRMVASDADGVSVPAGFTRIAAFRAGVGGDMDACYARYPG" FT misc_feature 163263..163295 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT misc_feature 163707..163736 FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS complement(164654..165064) FT /transl_table=11 FT /locus_tag="Rv0420c" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0420c, (MTCY22G10.17c), len: 136 aa. Possible FT transmembrane protein; has potential transmembrane domains FT aa 53-99 and aa 100-122." FT /db_xref="GOA:P96266" FT /db_xref="UniProtKB/TrEMBL:P96266" FT /protein_id="CAB06560.1" FT /translation="MRLHDASAAAPESRMHIARHGEAVNRRQMFIGITGLLLAVIGLMA FT LWFPVYLDQYDAYGIKVTCGSGWRSNLTQALYADGNDNTQALVTRCDTALLVRRAWAIP FT SVALGWLLVTGFLVMWVHNDQHQGQSYPGYRA" FT CDS complement(165225..165854) FT /transl_table=11 FT /locus_tag="Rv0421c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0421c, (MTCY22G10.18c), len: 209 aa. Conserved FT hypothetical protein, showing similarity with FT NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical FT protein from Mesorhizobium loti (214 aa)." FT /db_xref="UniProtKB/TrEMBL:P96267" FT /protein_id="CAB06561.1" FT /translation="MNLDQIAGVAHQPAGPPHGVVVLTHGAGGSRESTLLQQVCAEWTR FT RGWLAVRYNLPYRRRRPTGPPSGSGSGDRAGIVEAIQLCRGLAEGPLIAGGHSYGGRQT FT SMVVAAGQAPVDVLTLFSYPVHPPGKPERVRTEHLPGIAVPTVFTHGTADPFGTLAQVR FT SAAAMVSAPTEVVEITGARHDLGSKTLDVARLAVDAALRLSAGQIA" FT CDS complement(165851..166648) FT /transl_table=11 FT /gene="thiD" FT /locus_tag="Rv0422c" FT /product="PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID FT (HMP-PHOSPHATE KINASE) (HMP-P KINASE)" FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS. CATALYZES THE FT PHOSPHORYLATION OF HMP-P TO HMP-PP [CATALYTIC ACTIVITY: ATP FT + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + FT 4-amino-2-methyl-5-diphosphomethylpyrimidine]." FT /EC_number="2.7.4.7" FT /note="Rv0422c, (MTCY22G10.19c), len: 265 aa. Probable FT thiD, phosphomethylpyrimidine kinase (EC 2.7.4.7), FT equivalent to AL035159|MLCB1450_21 PHOSPHOMETHYLPYRIMIDINE FT KINASE from Mycobacterium leprae (279 aa), FASTA scores: FT opt: 1386, E(): 0, (77.8% identity in 266 aa overlap). Also FT highly similar to others e.g. HIU32725_3|P44697|THID_HAEIN FT PHOSPHOMETHYLPYRIMIDINE KINASE from Haemophilus influenzae FT (269 aa), FASTA scores: opt: 605, E(): 0, (42.1% identity FT in 259 aa overlap). BELONGS TO THE THID FAMILY." FT /db_xref="GOA:P66913" FT /db_xref="HSSP:1JXH" FT /db_xref="InterPro:IPR004399" FT /db_xref="UniProtKB/Swiss-Prot:P66913" FT /protein_id="CAB06562.1" FT /translation="MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQN FT TLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLV FT VDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRAAAK FT ALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAA FT ALAHGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS" FT CDS complement(166675..168318) FT /transl_table=11 FT /gene="thiC" FT /locus_tag="Rv0423c" FT /product="PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC" FT /function="INVOLVED IN THIAMINE BIOSYNTHESIS. REQUIRED FOR FT THE SYNTHESIS OF THE HYDROMETHYLPYRIMIDINE (HMP) MOIETY OF FT THIAMINE (4-AMINO-2-METHYL-5-HYDROXYMETHYLPYRIMIDINE)." FT /note="Rv0423c, (MTCY22G10.20c), len: 547 aa. Probable FT thiC, thiamin biosynthesis protein, equivalent to FT Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22 FT THIAMINE BIOSYNTHESIS PROTEIN from Mycobacterium leprae FT (547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity FT in 547 aa overlap). Also highly similar to others e.g. FT P45740|THIC_BACSU THIAMIN BIOSYNTHESIS PROTEIN from FT Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E(): FT 0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI FT THIC PROTEIN from Escherichia coli strain K12 (631 aa), FT FASTA scores: opt: 2141, E(): 0, (62.1% identity in 568 aa FT overlap); etc. BELONGS TO THE THIC FAMILY." FT /db_xref="GOA:P66911" FT /db_xref="InterPro:IPR002817" FT /db_xref="UniProtKB/Swiss-Prot:P66911" FT /protein_id="CAB06563.1" FT /translation="MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTG FT DHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIAARED FT MSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEVDKM FT VWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELTWEIY FT RDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYT FT NFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIE FT GPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAM FT LCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTARFEFRWND FT QFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRITQDVREYAAEHGLETEA FT DIEAVLAAGMAEKSREFAEHGNRVYLPITQ" FT CDS complement(168470..168745) FT /transl_table=11 FT /locus_tag="Rv0424c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0424c, (MTCY22G10.21c), len: 91 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P96270" FT /protein_id="CAB06564.1" FT /translation="MAEKNTRRATSQREAVAKIREAETIVMNLPICGQVKIPRPEHLAY FT YGGLAALAALELIDWPVALVIATGHILANNHHNRVLEELGEAMEEA" FT CDS complement(168795..173414) FT /transl_table=11 FT /gene="ctpH" FT /locus_tag="Rv0425c" FT /product="POSSIBLE METAL CATION TRANSPORTING P-TYPE ATPASE FT CTPH" FT /function="METAL CATION-TRANSPORTING ATPASE; POSSIBLY FT CATALYZES THE TRANSPORT OF UNDETERMINATED METAL CATION WITH FT HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT UNDETERMINATED METAL CATION(IN) = ADP + PHOSPHATE + FT UNDETERMINATED METAL CATION(OUT)]." FT /EC_number="3.6.1.-" FT /note="Rv0425c, (MTCY22G10.22c), len: 1539 aa. Possible FT ctpH, metal cation-transporting P-type ATPase FT (transmembrane protein) (EC 3.6.1.-), showing some FT similarity with FT CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative FT cation-transporting ATPase from Mycobacterium leprae (1609 FT aa). Also similar to others ATPases e.g. AE000873_1 FT CATION-TRANSPORTING P-ATPASE from Methanobacterium FT thermoautotrop (844 aa), FASTA score: (30.5% identity in FT 827 aa overlap); AB69720.1|AL137166 putative transport FT ATPase from Streptomyces coelicolor (1472 aa); etc. FT C-terminal region similar to other ATPases from FT Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative FT cation-transporting ATPase C (855 aa), FASTA scores: opt: FT 770, E(): 5.3e-32, (44.9% identity in 820 aa overlap)." FT /db_xref="GOA:P96271" FT /db_xref="InterPro:IPR008250" FT /db_xref="UniProtKB/TrEMBL:P96271" FT /protein_id="CAB06565.1" FT /translation="MPVRAVATGFRATATLTGASITAATAVSATLAKTGVGTGMKVAII FT PLRAGAKALSGELSRETLGRNCWRGERRAWIEVRGLRSGGDDELGRVVLNAIQAHPGVG FT SASLNYPLSRVVVAIDDPDTSLRELCRIVDDAEKAERHRHPDQAADQLAQSPGSLPGDG FT VLLAVRAVTVAATAAGLGLALGGRALRWPRFPLVIEAAVAAVDHQPLLRRLLEDRIGTE FT ATATVLELAMAAAHTVTLSPAALSVDLTIQALKAAECRAGARAWRRHEPQLALHADEPA FT DQPQSLWPRPARSTQPVQRSVARFALIQALSAVLVGAGTRDADMAATATLVATPKASRT FT TPEAFAAALGQGLADQHAVLPLRPESLRRLDRVDAIVIDPRVLCTDDLRVARIRGCGAD FT ELSTAWNRAQLVLTESGLRPGWHRVPGVSASGSDSAVEALFRPMHDRLASAVVAEAHRT FT GADLVSVDVDALGELRPVFDDIRPLDDGASGSLDEALARAVAELRQAGRTVAVLSSVGK FT QALSAADVALGVLPPPGAGAPPWYADVLLPDLGAAWRVLHAIPAARAARQRGNEISGGA FT SALGALLMLPGVRGLGPGPVTTGAAAGLLSGYLLARKVVDAQAPRPAPAHEWHAMSVEQ FT VRKALPSPDEQAPAKAPPSPYPARALAGGLHTAKRGAQITQAPLNALWQLTKAMRAELS FT DPLTPMLALGAMASAVLGSPVDAVMVGSVLTGNSILAASQRLRAESRLNRLLAQQIPPA FT RKVLAGADDQPRYIEVRAEELRPGDIIEVRTHEVVPADARVIEEVDVEVDESALTGESL FT SVTKQVEPTPGVDLIERRCMLYAGTTVVSGTAVAVVTAVGPDTQERRAAELVSGDLSSV FT GLQHQLSRLTNQAWPVSMTGGALVTGLGLLRRRGLRQAVASGIAVTVAAVPEGMPLVAT FT LAQQASARRLSHFGALVRIPRSVEALGRVDMVCFDKTGTLSENRLRVAQVRPVAGHSRE FT EVLRCAAHAAPASNGPQVHATDVAIVQAAAAAAASGTDGAEPGAAEPAAHLPFRSGRSF FT SASVSGTELTVKGAPEVVLAACEGIGSSMDDAVAELAANGLRVIAVAHRQLTAQQAQSV FT VDDPDEIARLCRDELSLVGFLGLSDTPRAQAAALLADLHEHDLDIRLITGDHPITAAAI FT AEELGMQVSPEQVISGAEWDALSRKDQERAVAERVIFARMTPENKVQIVQTLEHSGRVC FT AMVGDGSNDAAAIRAATVGIGVVAHGSDPARVAADLVLVDGRIESLLPAILEGRQLWQR FT VQAAVSVLLGGNAGEVAFAIIGSAITGTSPLNTRQLLLVNMLTDALPAAALAVSKPSDP FT VTPATRGPDQRELWRAVGIRGATTAAAATVAWVMAGFTGLPRRASTVALVALVAAQLGQ FT TLVDSHAWLVVLTALGSLAALATLISIPVVSQLLGCTPLDPLGWAQATAAATAATVAVA FT VLNRVLTGRDKSGQPNPQPPETDALSRDASPGAPPGPRRRRRATARRKAPVKAPSATRQ FT TTKPKGPPAHRSSSTYPRR" FT CDS complement(173466..173909) FT /transl_table=11 FT /locus_tag="Rv0426c" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0426c, (MTCY22G10.23c), len: 147 aa. Possible FT transmembrane protein; has potential transmembrane domains FT aa 19-41, and aa 61-83." FT /db_xref="GOA:P96272" FT /db_xref="UniProtKB/TrEMBL:P96272" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB06566.1" FT /translation="MSVVGGTVRTVGRTVSGAATATTAAAGAVGGAAVSGIVGGVTGAA FT KGIQKGLSSGSKSTAAAALAIGAIGVAGLVDWPILLAVGGGALLLRKLNRTPEVAAPPV FT KAKLAPVPDKPAAAKEAPAKASKTTARKTSGRRAGTAELRSTN" FT CDS complement(174110..174985) FT /transl_table=11 FT /gene="xthA" FT /locus_tag="Rv0427c" FT /standard_name="xth" FT /product="PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA FT (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI)" FT /function="INVOLVED IN BASE EXCISION REPAIR. FT APURINIC-APYRIMIDINIC ENDONUCLEASE. SUPPOSED TO REMOVE THE FT DAMAGED DNA AT CYTOSINES AND GUANINES BY CLEAVING AT THE 3' FT SIDE OF THE AP SITE BY A BETA-ELIMINATION REACTION. FT POSSIBLY EXHIBITES 3'-5'-EXONUCLEASE, FT 3'-PHOSPHOMONOESTERASE, 3'-REPAIR DIESTERASE AND FT RIBONUCLEASE H ACTIVITIES [CATALYTIC ACTIVITY: Degradation FT of double-stranded DNA. It acts progressively in a 3'- to FT 5'-direction, releasing 5'-phosphomononucleotides]." FT /EC_number="3.1.11.2" FT /note="Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable xthA FT (alternate gene name: xth), exodeoxyribonuclease III FT protein (EC 3.1.11.2) (see citation below), similar to FT others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from FT Escherichia Coli strain K12 (268 aa), FASTA scores: opt: FT 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. FT BELONGS TO THE AP/EXOA FAMILY OF DNA REPAIR ENZYMES." FT /db_xref="GOA:P96273" FT /db_xref="HSSP:1E9N" FT /db_xref="InterPro:IPR005135" FT /db_xref="UniProtKB/TrEMBL:P96273" FT /protein_id="CAB06567.1" FT /translation="MPDGTIDGGHPQRPASPRLRSPLLRLATWNVNSIRTRLDRVLDWL FT GRADVDVLAMQETKCPDGQFPALPLFELGYDVAHVGFDQWNGVAIASRVGLDDVRVGFD FT GQPSWSGKPEVAATTEARALGATCGGIRVWSLYVPNGRALDDPHYTYKLDWLAALRDTA FT EGWLRDDPAAPIALMGDWNIAPTDDDVWSTEFFAGCTHVSEPERKAFNAIVDAQFTDVV FT RPFTPGPGVYTYWDYTQLRFPKKQGMRIDFILGSPALAARVMDAQIVREERKGKAPSDH FT APVLVDLHAG" FT CDS complement(174988..175896) FT /transl_table=11 FT /locus_tag="Rv0428c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0428c, (MTCY22G10.25c), len: 302 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P96274" FT /protein_id="CAB06568.1" FT /translation="MVSWPGLGTRVTVRYRRPAGSMPPLTDAVGRLLAVDPTVRVQTKT FT GTIVEFSPVDVVALRVLTDAPVRTAAIRALEHAAAAAWPGVERTWLDGWLLRAGHGAVL FT AANSAVPLDISAHTNTITEISAWYASRDLQPWLAVPDRLLPLPADLAGERREQVLVRDV FT STGEPDRSVTLLDHPDDTWLRLYHQRLPLDMATPVIDGELAFGSYLGVAVARAAVTDAP FT DGTRWVGLSAMRAADEQSATGSAGRQLWEALLGWGAGRGATRGYVRVHDTATSVLAESL FT GFRLHHHCRYLPAQSVGWDTF" FT CDS complement(175896..176489) FT /transl_table=11 FT /gene="def" FT /locus_tag="Rv0429c" FT /product="PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) FT (FORMYLMETHIONINE DEFORMYLASE)" FT /function="REMOVES THE FORMYL GROUP FROM THE N-TERMINAL MET FT OF NEWLY SYNTHESIZED PROTEINS [CATALYTIC ACTIVITY: FT N-formyl-L-methionine + H2O = formate + L-methionine]." FT /EC_number="3.5.1.31" FT /note="Rv0429c, (MTCY22G10.26c), len: 197 aa. Probable def, FT polypeptide deformylase (EC 3.5.1.31), equivalent to FT CAC30884.1|AL583923 polypeptide deformylase from FT Mycobacterium leprae (197 aa). Also similar to others e.g. FT DEF_ECOLI|P27251|95874|S23107 polypeptide deformylase from FT Escherichia coli (169 aa), FASTA scores: opt: 179, E(): FT 1.8e-05, (34.6% identity in 162 aa overlap); etc. BELONGS FT TO THE POLYPEPTIDE DEFORMYLASE FAMILY. COFACTOR: BINDS 1 FT ZINC ION." FT /db_xref="GOA:P96275" FT /db_xref="InterPro:IPR000181" FT /db_xref="PDB:3E3U" FT /db_xref="UniProtKB/Swiss-Prot:P96275" FT /protein_id="CAB06569.1" FT /translation="MAVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTMD FT AANGVGLAANQIGCSLRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTDDE FT GCLSVPGESFPTGRAKWARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLDRLI FT GRYARNAKRAVKSHGWGVPGLSWLPGEDPDPFGH" FT CDS 176826..177134 FT /transl_table=11 FT /locus_tag="Rv0430" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0430, (MTCY22G10.27), len: 102 aa. Conserved FT hypothetical protein, equivalent to AC30882.1|AL583923 FT conserved hypothetical protein from Mycobacterium leprae FT (102 aa). Also highly similar to FT CAB93047.1|SCD95A.20|AL357432 hypothetical protein from FT Streptomyces coelicolor (84 aa)." FT /db_xref="UniProtKB/TrEMBL:P96276" FT /protein_id="CAB06570.1" FT /translation="MDSAMARAIRSGDDAEVADGLTRREHDILAFERQWWKFAGVKEEA FT IKELFSMSATRYYQVLNALVDRPEALAADPMLVKRLRRLRASRQKARAARRLGFEVT" FT CDS 177166..177660 FT /transl_table=11 FT /locus_tag="Rv0431" FT /product="PUTATIVE TUBERCULIN RELATED PEPTIDE" FT /function="UNKNOWN" FT /note="Rv0431, (MTCY22G10.28), len: 164 aa. Putative FT tuberculin related peptide; almost identical to FT D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis FT (172 aa), FASTA score: (99.4% identity in 163 aa overlap). FT Highly similar to to CAC30881.1|AL583923 tuberculin related FT peptide (AT103) from Mycobacterium leprae (167 aa). Some FT similarity to G550415|HRPC (282 aa), FASTA scores: opt: FT 120, E(): 0.36, (33.3% identity in 111 aa overlap). FT Potential transmembrane domain at aa 19-37." FT /db_xref="UniProtKB/TrEMBL:P96277" FT /protein_id="CAB06571.1" FT /translation="MLVTVGSMNERVPDSSGLPLRAMVMVLLFLGVVFLLLVWQALGSS FT PNSEDDSSAISTMTTTTAAPTSTSVKPAAPRAEVRVYNISGTEGAAARTADRLKAAGFT FT VTDVGNLSLPDVAATTVYYTEVEGERATADAVGRTLGAAVELRLPELSDQPPGVIVVVT FT G" FT CDS 177693..178415 FT /transl_table=11 FT /gene="sodC" FT /locus_tag="Rv0432" FT /product="PROBABLE PERIPLASMIC SUPEROXIDE DISMUTASE [CU-ZN] FT SODC" FT /function="DESTROYS RADICALS WHICH ARE NORMALLY PRODUCED FT WITHIN THE CELLS AND ARE TOXIC TO BIOLOGICAL SYSTEMS FT [CATALYTIC ACTIVITY: 2 superoxide + 2 H+ = O2 + H2O2]." FT /EC_number="1.15.1.1" FT /note="Rv0432, (MTCY22G10.29), len: 240 aa. Probable sodC, FT periplasmic superoxide dismutase [Cu-Zn] (EC 1.15.1.1), FT equivalent to CAC30880.1|AL583923 superoxide dismutase FT precursor (Cu-Zn) from Mycobacterium leprae (240 aa); and FT AAK20038.1|AF326234_1 copper zinc superoxide dismutase from FT Mycobacterium avium subsp. paratuberculosis (226 aa). Also FT similar to others e.g. SODC_PHOLE|P00446 superoxide FT dismutase precursor (cu-zn) from Photobacterium leiognathi FT (173 aa), FASTA scores: opt: 214, E(): 5.2 e-06, (36.5% FT identity in 181 aa overlap). Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site. BELONGS TO THE FT CU-ZN SUPEROXIDE DISMUTASE FAMILY. Possibly localized in FT periplasm, membrane-bound." FT /db_xref="GOA:P0A608" FT /db_xref="InterPro:IPR001424" FT /db_xref="PDB:1PZS" FT /db_xref="UniProtKB/Swiss-Prot:P0A608" FT /protein_id="CAB06572.1" FT /translation="MPKPADHRNHAAVSTSVLSALFLGAGAALLSACSSPQHASTVPGT FT TPSIWTGSPAPSGLSGHDEESPGAQSLTSTLTAPDGTKVATAKFEFANGYATVTIATTG FT VGKLTPGFHGLHIHQVGKCEPNSVAPTGGAPGNFLSAGGHYHVPGHTGTPASGDLASLQ FT VRGDGSAMLVTTTDAFTMDDLLSGAKTAIIIHAGADNFANIPPERYVQVNGTPGPDETT FT LTTGDAGKRVACGVIGSG" FT misc_feature 177759..177791 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 178417..179547 FT /transl_table=11 FT /locus_tag="Rv0433" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0433, (MTCY22G10.30), len: 376 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. P77213|YBDK_ECOLI hypothetical 41.7 KD FT protein from Escherichia coli strain K12 (372 aa), FASTA FT scores: opt: 555, E(): 2e-30, (28.2% identity in 365 aa FT overlap)." FT /db_xref="GOA:P64693" FT /db_xref="InterPro:IPR011793" FT /db_xref="UniProtKB/Swiss-Prot:P64693" FT /protein_id="CAB06573.1" FT /translation="MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVIA FT EIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGTHP FT FARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNYYPH FT LLALSASSPWWGGEDTGYASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDH FT MDEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMP FT PWHVQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCADELAAVS FT DIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI" FT CDS 179607..180260 FT /transl_table=11 FT /locus_tag="Rv0434" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0434, (MTCY22G10.31), len: 217 aa. Conserved FT hypothetical protein, similar to AE002052_2 from FT Deinococcus radiodurans (213 aa), FASTA scores: opt: 258, FT E(): 4e-10, (31.9% identity in 213 aa overlap); FT SYCSLRB_122|Q55701 hypothetical 24.5 kDa protein from FT Synechocystis (214 aa), FASTA scores: opt: 156, E(): FT 0.00041, (28.4% identity in 204 aa overlap); FT MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent protease la 2 FT from Myxococcus xanthus (826 aa), FASTA scores: opt: 160, FT E(): 0.00068, (28.4% identity in 197 aa overlap); etc." FT /db_xref="GOA:P96280" FT /db_xref="InterPro:IPR003111" FT /db_xref="UniProtKB/TrEMBL:P96280" FT /protein_id="CAB06574.1" FT /translation="MADFAPVELAMFPLESAPLPDEDLPLHIFEPRYAALVRDCMDTAD FT PRFGVVLISRGREVGGGDTRCDVGTLARITECADAGSGRYMLRCRVGERIRVCDWLPDD FT PYPRAKVRFWPDQPGHPVTAAQLLEVEDRVVALFERIAAARGVRLPAREVVLGYPVVDP FT ADTGQRLYALACRVPMGPADRYAVLATPSAADRLVRLGDALDSVAAMVEFELST" FT CDS complement(180440..182626) FT /transl_table=11 FT /locus_tag="Rv0435c" FT /product="PUTATIVE CONSERVED ATPASE" FT /function="ATPASE; POSSIBLY CATALYZES THE TRANSPORT OF FT UNDETERMINATED SUBSTRATE WITH HYDROLYSE OF ATP [CATALYTIC FT ACTIVITY: ATP + H(2)O + UNDETERMINATED SUBSTRATE(IN) = ADP FT + PHOSPHATE + UNDETERMINATED SUBSTRATE(OUT)]." FT /EC_number="3.6.1.-" FT /note="Rv0435c, (MTCY22G10.32c), len: 728 aa. Putative FT conserved ATPase (EC 3.6.1.-), similar to others e.g. FT SAV_SULAC|Q07590 sav protein involved in cell division from FT sulfolobus acidocaldarius (780 aa), FASTA scores: opt: 897, FT E(): 0, (34.5% identity in 693 aa overlap); FT NP_148637.1|7435761|B72479 transitional endoplasmic FT reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also FT similar to Rv3610c and Rv2115c from Mycobacterium FT tuberculosis. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00674 AAA-protein family signature." FT /db_xref="GOA:P96281" FT /db_xref="HSSP:1R7R" FT /db_xref="InterPro:IPR009010" FT /db_xref="UniProtKB/TrEMBL:P96281" FT /protein_id="CAB06575.1" FT /translation="MTHPDPARQLTLTARLNTSAVDSRRGVVRLHPNAIAALGIREWDA FT VSLTGSRTTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTVYGARSVTLS FT GSTLATQSVPPVTLRQALLGKVMTVGDAVSLLPRDLGPGTSTSAASRALAAAVGISWTS FT ELLTVTGVDPDGPVSVQPNSLVTWGAGVPAAMGTSTAGQVSISSPEIQIEELKGAQPQA FT AKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCDGRRLVTLDGPEI FT GALAAGDRVKAVASAVQAVRHEGGVLLITDADALLPAAAEPVASLILSELRTAVATAGV FT VLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTGDLNLDEIAS FT RTPGFVVADLAALVREAALRAASRASADGRPPMLHQDDLLGALTVIRPLSRSASDEVTV FT GDVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRA FT LASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQS FT FDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFVEPPDA FT AARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAANVT FT AADLATARETVRASLDPLQVASLRKFGTKGDLRS" FT misc_feature complement(180767..180823) FT /note="PS00674 AAA-protein family signature" FT misc_feature complement(181091..181114) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(182623..183483) FT /transl_table=11 FT /gene="pssA" FT /locus_tag="Rv0436c" FT /product="PROBABLE CDP-DIACYLGLYCEROL--SERINE FT O-PHOSPHATIDYLTRANSFERASE PSSA (PS SYNTHASE) FT (PHOSPHATIDYLSERINE SYNTHASE)" FT /function="INVOLVED IN PHOSPHOLIPID BIOSYNTHESIS. GENERATES FT PHOSPHATIDYLSERINE [CATALYTIC ACTIVITY: CDP-diacylglycerol FT + L-serine = CMP + O-Sn-phosphatidyl-L-serine]." FT /EC_number="2.7.8.8" FT /note="Rv0436c, (MTCY22G10.33c), len: 286 aa. Probable FT pssA, PS synthase (CDP-diacylglycerol--serine FT O-phosphatidyltransferase) (EC 2.7.8.8) (see citation FT below), integral membrane protein, equivalent to FT AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 FT aa), FASTA scores: opt: 1506, E(): 0, (77.9% identity in FT 285 aa overlap). Also highly similar to others e.g. FT NP_108059.1|14027250|BAB54204.1|AP003012 phosphatidylserine FT synthase from Mesorhizobium loti (248 aa); PSS_BACSU|P39823 FT cdp-diacylglycerol--serine o-phosphatidyltransferase from FT Bacillus subtilis (177 aa), FASTA scores: opt: 277, E(): FT 9.9e-12, (33.3% identity in 183 aa overlap); etc. Contains FT PS00379 CDP-alcohol phosphatidyltransferases signature. FT BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FT FAMILY." FT /db_xref="GOA:P96282" FT /db_xref="InterPro:IPR000462" FT /db_xref="UniProtKB/Swiss-Prot:P96282" FT /protein_id="CAB06576.1" FT /translation="MIGKPRGRRGVNLQILPSAMTVLSICAGLTAIKFALEHQPKAAMA FT LIAAAAILDGLDGRVARILDAQSRMGAEIDSLADAVNFGVTPALVLYVSMLSKWPVGWV FT VVLLYAVCVVLRLARYNALQDDGTQPAYAHEFFVGMPAPAGAVSMIGLLALKMQFGEGW FT WTSGWFLSFWVTGTSILLVSGIPMKKMHAVSVPPNYAAALLAVLAICAAAAVLAPYLLI FT WVIIIAYMCHIPFAVRSQRWLAQHPEVWDDKPKQRRAVRRASRRAHPYRPSMARLGLRK FT PGRRL" FT misc_feature complement(183247..183315) FT /note="PS00379 CDP-alcohol phosphatidyltransferases FT signature" FT CDS complement(183480..184175) FT /transl_table=11 FT /gene="psd" FT /locus_tag="Rv0437c" FT /product="POSSIBLE PHOSPHATIDYLSERINE DECARBOXYLASE PSD (PS FT DECARBOXYLASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID METABOLISM FT [CATALYTIC ACTIVITY: PHOSPHATIDYL-L-SERINE = FT PHOSPHATIDYLETHANOLAMINE + CO(2)]." FT /EC_number="4.1.1.65" FT /note="Rv0437c, (MTV037.01c), len: 231 aa (start FT uncertain). Possible psd, phosphatidylserine decarboxylase FT (EC 4.1.1.65), equivalent to CAC29819.1|AL583918 conserved FT hypothetical protein from Mycobacterium leprae (243 aa); FT and highly similar to FT MLCB1450.11|T44729|4154044|CAA22695.1|AL035159 hypothetical FT protein from Mycobacterium leprae (202 aa), FASTA score: FT (74.6% identity in 197 aa overlap). Also similar to other FT phosphatidylserine decarboxylases e.g. FT NP_108058.1|14027249|BAB54203.1|AP003012 phosphatidylserine FT decarboxylase from Mesorhizobium loti (232 aa); FT AAK86872|g15156090|AGR_C_1963 phosphatidylserine FT decarboxylase from Agrobacterium tumefaciens (244 aa); FT AAG12422.1|AY005137|Psd phosphatidylserine decarboxylase FT from Chlorobium tepidum (216 aa); etc. TBparse score is FT 0.890." FT /db_xref="GOA:P67547" FT /db_xref="InterPro:IPR004428" FT /db_xref="UniProtKB/Swiss-Prot:P67547" FT /protein_id="CAB06588.1" FT /translation="MARRPRPDGPQHLLALVRSAVPPVHPAGRPFIAAGLAIAAVGHRY FT RWLRGTGLLAAAACAGFFRHPQRVPPTRPAAIVAPADGVICAIDSAAPPAELSMGDTPL FT PRVSIFLSILDAHVQRAPVSGEVIAVQHRPGRFGSADLPEASDDNERTSVRIRMPNGAE FT VVAVQIAGLVARRIVCDAHVGDKLAIGDTYGLIRFGSRLDTYLPAGAEPIVNVGQRAVA FT GETVLAECR" FT CDS complement(184236..185453) FT /transl_table=11 FT /gene="moeA2" FT /locus_tag="Rv0438c" FT /standard_name="moeA3" FT /product="PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN FT MOEA2" FT /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS: FT INVOLVED IN THE BIOSYNTHESIS OF A DEMOLYBDO-COFACTOR FT (MOLYBDOPTERIN), NECESSARY FOR MOLYBDO-ENZYMES (BY FT SIMILARITY)." FT /note="Rv0438c, (MTV037.02c), len: 405 aa. Probable moeA2, FT molybdenum cofactor biosynthesis protein, highly similar to FT many e.g. Y10817|ANY10817_2 from A. nicotinovorans (429 FT aa), FASTA scores: opt: 786, E(): 0, (39.2% identity in 398 FT aa overlap); etc. Also similar to FT MOEA1|Rv0994|MTCI237.08|O05577 PROBABLE MOLYBDOPTERIN FT BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (426 FT aa), FASTA scores: opt: 667, E(): 2e-32, (36.5% identity in FT 425 aa overlap). TBparse score is 0.889. Note that FT previously known as moeA3." FT /db_xref="GOA:O53725" FT /db_xref="HSSP:1G8L" FT /db_xref="InterPro:IPR001453" FT /db_xref="UniProtKB/Swiss-Prot:O53725" FT /protein_id="CAE55280.1" FT /translation="MRSVQEHQRVVAEMMRACRPITVPLTQAQGLVLGGDVVAPLSLPV FT FDNSAMDGYAVRAEDTSGATPQNPVMLPVAEDIPAGRADMLTLQPVTAHRIMTGAPVPT FT GATAIVPVEATDGGVDSVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLGLAA FT ALGLAELPVLPRQRVLVISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAVVATA FT TAGDDVAQFGAILDRYAVDADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEFVKVA FT MQPGMPQGVGRVAGTPIVTLPGNPVSALVSFEVFIRPPLRMAMGLPDPYRPHRSAVLTA FT SLTSPRGKRQFRRAILDHQAGTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQL FT QVWDLT" FT CDS complement(185472..186407) FT /transl_table=11 FT /locus_tag="Rv0439c" FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0439c, (MTV037.03c), len: 311 aa. Probable FT dehydrogenase/reductase (EC 1.-.-.-), equivalent to FT AL035159|MLCB1450_6|T44727 probable oxidoreductase from FT Mycobacterium leprae (304 aa), FASTA scores: opt: 1360, FT E(): 0, (69.2% identity in 302 aa overlap). Also highly FT similar to various oxidoreductases, generally FT dehydrogenases/reductases e.g. FT PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 FT probable short chain dehydrogenase from Pseudomonas FT aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE FT OXIDOREDUCTASE from Streptomyces antibioticus (298 aa), FT FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in FT 298 aa overlap); etc. TBparse score is 0.903." FT /db_xref="GOA:O53726" FT /db_xref="HSSP:1N5D" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O53726" FT /protein_id="CAA17396.1" FT /translation="MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRG FT AHVVLAVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPRIDVL FT INNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGSRVVTVSSQGHRIH FT AAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRRLGEAGKSTIAVAAHPGGSNTEL FT TRNLPRLIRPVATVLGPLLFQSPEMGALPTLRAATDPTTQGGQYYGPDGFGEQRGHPKV FT VQSSAQSHDKDLQRRLWTVSEELTGVSFGV" FT CDS 186701..188323 FT /transl_table=11 FT /gene="groEL2" FT /locus_tag="Rv0440" FT /standard_name="groL2; groEL-2; hsp65; hsp60" FT /product="60 KDA CHAPERONIN 2 GROEL2 (PROTEIN CPN60-2) FT (GROEL PROTEIN 2) (65 KDA ANTIGEN) (HEAT SHOCK PROTEIN 65) FT (CELL WALL PROTEIN A) (ANTIGEN A)" FT /function="PREVENTS MISFOLDING AND PROMOTES THE REFOLDING FT AND PROPER ASSEMBLY OF UNFOLDED POLYPEPTIDES GENERATED FT UNDER STRESS CONDITIONS." FT /note="Rv0440, (MTV037.04), len: 539 aa. groEL2 (alternate FT gene names: groL2, groEL-2, hsp65, hsp60), 60 kDa FT chaperonin 2 (see Shinnick 1987). PURIFIED 65 kDa ANTIGEN FT CAN ELICIT A STRONG DELAYED-TYPE HYPERSENSITIVITY REACTION FT IN EXPERIMENTAL ANIMALS INFECTED WITH M. TUBERCULOSIS. THIS FT PROTEIN IS ONE OF THE MAJOR IMMUNOREACTIVE PROTEINS OF THE FT MYCOBACTERIA. THIS ANTIGEN CONTAINS EPITOPES THAT ARE FT COMMON TO VARIOUS SPECIES OF MYCOBACTERIA. Contains PS00296 FT Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN FT (HSP60) FAMILY. TBparse score is 0.847." FT /db_xref="GOA:P0A520" FT /db_xref="InterPro:IPR002423" FT /db_xref="PDB:1SJP" FT /db_xref="UniProtKB/Swiss-Prot:P0A520" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17397.1" FT /translation="MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGA FT PTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLR FT NVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEA FT MDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVS FT SKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGD FT RRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAI FT AGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVR FT NAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLE FT PGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAV FT VADKPEKEKASVPGGGDMGGMDF" FT misc_feature 187907..187942 FT /note="PS00296 Chaperonins cpn60 signature" FT CDS complement(188389..188817) FT /transl_table=11 FT /locus_tag="Rv0441c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0441c, (MTV037.05c), len: 142 aa. Hypothetical FT unknown protein. TBparse score is 0.897." FT /db_xref="InterPro:IPR020145" FT /db_xref="UniProtKB/Swiss-Prot:P0A5C7" FT /protein_id="CAA17398.1" FT /translation="MGAKKVDLKRLAAALPDYPFAYLITVDDGHRVHTVAVEPVLRELP FT DGPDGPRAVVDVGLIGGRTRQNLAHRSEVTLLWPPSDPSGYSLIVDGRAQASDAGPDDD FT TARCGVVPIRALLHRDAAPDSPTAAKGCLHDCVVFSVP" FT CDS complement(188844..190307) FT /transl_table=11 FT /gene="PPE10" FT /locus_tag="Rv0442c" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0442c, (MTV037.06c), len: 487 aa. Member of the FT Mycobacterium tuberculosis PPE family, nearly identical to FT hypothetical protein from Mycobacterium tuberculosis FT (strain Erdman) and to AN5S46909_1 protein fragment from FT Mycobacterium bovis (302 aa); P42611|YHS6_MYCTU FT HYPOTHETICAL 50.6 kDa PROTEIN (517 aa), FASTA scores: opt: FT 3144, E(): 0, (98.4 identity in 492 aa overlap); and FT S46909|S46909_1 (302 aa), FASTA scores: opt: 1897, E(): 0, FT (98.0% identity in 302 aa overlap). TBparse score is FT 0.903." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/Swiss-Prot:P42611" FT /protein_id="CAE55281.1" FT /translation="MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEKLLASI FT ASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAAAQAMAIATAFEAAL FT AATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVEAAYEQMWALDVAAMAGYHFDASA FT AVAQLAPWQQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIGSGNTGTGNIGS FT GNTGSGNLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSGTGN FT VGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAALGSAAGS FT EAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPVAAPASAP FT VGGLDSGNPNPGSGSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVREPSTPGS FT GIPKSNFYPSPDRESAYASPRIGQPVGSE" FT CDS 190489..191004 FT /transl_table=11 FT /locus_tag="Rv0443" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0443, (MTV037.07), len: 171 aa. Conserved FT hypothetical protein, highly similar to FT AL049863|SC5H1_23|T35339 hypothetical protein from FT Streptomyces coelicolor (171 aa), FASTA scores: opt: 561, FT E(): 2.3e-32, (49.7% identity in 165 aa overlap); and FT CAC42482.1|AJ318385 hypothetical protein from Amycolatopsis FT mediterranei (163 aa). TBparse score is 0.915." FT /db_xref="UniProtKB/TrEMBL:O53728" FT /protein_id="CAA17400.1" FT /translation="MASTDAAAQELLRDAFTRLIEHVDELTDGLTDQLACYRPTPSANS FT IAWLLWHSARVQDIQVAHVAGVEEVWTRDGWVDRFGLDLPRHDTGYGHRPEDVAKVRAP FT ADLLSGYYHAVHKLTLEYIAGMTADELSRVVDTSWNPPVTVSARLVSIVDDCAQHLGQA FT AYLRGIAR" FT CDS complement(191184..191882) FT /transl_table=11 FT /locus_tag="Rv0444c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0444c, (MTV037.08c), len: 232 aa. Conserved FT hypothetical protein; C-terminus similar to FT P12752|Y24K_STRGR HYPOTHETICAL 24.7 kDa PROTEIN from FT Streptomyces griseus (238 aa), FASTA scores: opt: 207, E(): FT 2.2e-05, (32.9% identity in 158 aa overlap). TBparse score FT is 0.914." FT /db_xref="GOA:O53729" FT /db_xref="InterPro:IPR018764" FT /db_xref="UniProtKB/Swiss-Prot:O53729" FT /protein_id="CAA17401.1" FT /translation="MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFN FT DEVRAVRETMAVVSAATTAEPPAHLRTAILDATKPEVRRQSRWRTAAFASAAAIAVGLG FT AFGLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNVAPP FT SRGTVYQMWLLGGAKGPRSAGTMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPT FT GTILAELPLG" FT CDS complement(191926..192489) FT /transl_table=11 FT /gene="sigK" FT /locus_tag="Rv0445c" FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGK" FT /function="INVOLVED IN TRANSCRIPTION MECHANISM. THE SIGMA FT FACTOR IS AN INITIATION FACTOR THAT PROMOTES ATTACHMENT OF FT THE RNA POLYMERASE TO SPECIFIC INITIATION SITES AND THEN IS FT RELEASED." FT /note="Rv0445c, (MTV037.09c), len: 187 aa. Probable sigK, FT alternative RNA polymerase sigma factor (see citations FT below), highly similar to others e.g. FT 5531433|CAB50938.1|AL096849|T36745 probable RNA polymerase FT sigma factor from Streptomyces coelicolor (185 aa); FT NP_105607.1|14024791|BAB51393.1|AP003005 RNA polymerase FT sigma factor from Mesorhizobium loti (179 aa); FT 1654108|AAB17906.1|U11283|A58883 probable transcription FT initiation factor sigma E from Rhodobacter phaeroides (168 FT aa), FASTA scores: opt: 299, E(): 2e-14, (32.7% identity in FT 168 aa overlap); Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FT FACTOR SIGW from Bacillus subtilis (187 aa), FASTA scores: FT opt: 213, E(): 2.9e-08, (26.8% identity in 179 aa overlap); FT etc. TBparse score is 0.900." FT /db_xref="GOA:O53730" FT /db_xref="InterPro:IPR007630" FT /db_xref="UniProtKB/Swiss-Prot:O53730" FT /protein_id="CAA17402.1" FT /translation="MTGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVYGLVMRVL FT RDTGYSEETTQEIYLEVWRNASEFDSAKGSALAWLLTMAHRRAVDRVRCEQAGNQREVR FT YGAANVDPASDVVADLAIAGDERRRVTECLKALTDTQRQCIELAYYGGLTYVEVSRRLA FT ANLSTIKSRMRDALRSLRNCLDVS" FT CDS complement(192538..193308) FT /transl_table=11 FT /locus_tag="Rv0446c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0446c, (MTV037.10c), len: 256 aa. Possible FT conserved transmembrane protein, similar at N-terminus to FT U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 FT aa), FASTA scores: opt: 175, E(): 2.5e-05, (62.5% identity FT in 40 aa overlap); and at C-terminus to AL021529|SC10A5_3 FT from Streptomyces coelicolor (226 aa), FASTA scores: opt: FT 207, E(): 9.8e-07, (34.2% identity in 114 aa overlap). Also FT similar to others hypothetical proteins e.g. FT AAK04680.1|AE006291_14|AE006291) HYPOTHETICAL PROTEIN from FT Lactococcus lactis subsp. lactis (257 aa). TBparse score is FT 0.920." FT /db_xref="GOA:O53731" FT /db_xref="InterPro:IPR001104" FT /db_xref="UniProtKB/TrEMBL:O53731" FT /protein_id="CAA17403.1" FT /translation="MVTSVSALAVAVVHSVAFAIGRRIGRYNVVDVVWGLGFVAVAVAA FT ATLGHGDPVRRWLLLALVSTWGLRLSWHMYRKTAGQGEDPRYADLLRGATPVQALRKVF FT GLQGLLTLFVSFPLQLSAVTGPTPKPLLAVGGVGLAVWLVGITFEAVGDWQLWVFKSDP FT ANRGVIMDRGLWAWTRHPNYFGDACVWWGLWLITINDWAPLATVGSPLLMTYLLVDVSG FT ARLTERYLKGRPGFAEYQRRTAYFVPRPPRSARR" FT CDS complement(193317..194600) FT /transl_table=11 FT /gene="ufaA1" FT /locus_tag="Rv0447c" FT /product="PROBABLE CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID FT SYNTHASE UFAA1 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA FT SYNTHASE)" FT /function="TRANSFERS A METHYLENE GROUP FROM FT S-ADENOSYL-L-METHIONINE TO THE CIS DOUBLE BOND OF AN FT UNSATURATED FATTY ACID CHAIN RESULTING IN THE REPLACEMENT FT OF THE DOUBLE BOND WITH A METHYLENE BRIDGE [CATALYTIC FT ACTIVITY: S-adenosyl-L-methionine + phospholipid olefinic FT fatty acid = S-adenosyl-L-homocysteine + phospholipid FT cyclopropane fatty acid]." FT /EC_number="2.1.1.79" FT /note="Rv0447c, (MTV037.11c), len: 427 aa (start FT uncertain). Probable ufaA1, FT cyclopropane-fatty-acyl-phospholipid synthase (EC FT 2.1.1.79), similar to others e.g. FT NP_102178.1|14021351|BAB47964.1|AP002994 FT cyclopropane-fatty-acyl-phospholipid synthase from FT Mesorhizobium loti (378 aa); FT B82240|9655593|AAF94281.1|AE004192 FT cyclopropane-fatty-acyl-phospholipid synthase from Vibrio FT cholerae (432 aa); P30010|CFA_ECOLI FT CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from FT Escherichia coli strain K-12 (382 aa); X55704|PPLPD_3 LPD-3 FT from P.putida (394 aa), FASTA scores: opt: 556, E(): FT 2.8e-30, (33.3% identity in 387 aa overlap); FT AE0005|HPAE000557_9 from Helicobacter pylori (389 aa), FT FASTA scores: opt: 539, E(): 3.9e-29, (34.3% identity in FT 382 aa overlap). TBparse score is 0.919." FT /db_xref="GOA:O53732" FT /db_xref="HSSP:1KPH" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/TrEMBL:O53732" FT /protein_id="CAA17404.1" FT /translation="MTVETSQTPSAAIDSDRWPAVAKVPRGPLAAASAAIANRLLRRTA FT THLPLRLVYSDGTATGAADPRAPSLFIHRPDALARRIGRHGLIGFGESYMAGEWSSKEL FT TRVLTVLAGSVDELVPRSLHWLRPITPTFRPSWPDHSRDQARRNIAVHYDLSNDLFAAF FT LDETMTYSCAMFTDLLAQPTPAWTELAAAQRRKIDRLLDVAGVQQGSHVLEIGTGWGEL FT CIRAAARGAHIRSVTLSVEQQRLARQRVAAAGFGHRVEIDLCDYRDVDGQYDSVVSVEM FT IEAVGYRSWPRYFAALEQLVRPGGPVAIQAITMPHHRMLATRHTQTWIQKYIFPGGLLP FT STQAIIDITGQHTGLRIVDAASLRPHYAETLRLWRERFMQRRDGLAHLGFDEVFARMWE FT LYLAYSEAGFRSGYLDVYQWTLIREGPP" FT CDS complement(194597..195262) FT /transl_table=11 FT /locus_tag="Rv0448c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0448c, (MTV037.12c), len: 221 aa. Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283 aa), FT FASTA scores: opt: 257, E(): 1.4e-10, (32.0% identity in FT 197 aa overlap); etc. Some similarity to U15183|MLU15183_38 FT from Mycobacterium leprae (82 aa), FASTA scores: opt: 134, FT E(): 0.014, (71.0% identity in 31 aa overlap). TBparse FT score is 0.934." FT /db_xref="InterPro:IPR010775" FT /db_xref="UniProtKB/TrEMBL:O53733" FT /protein_id="CAA17405.1" FT /translation="MHHSFAYRSYSWYVDVDNLPQLPWWLRPFARFHADDHFADPFSCP FT PHSSLRDRLDAFFAARGLAVPDGRITALLQARVLGYVFNPLSIFWCHDRDGQLRHVIAE FT VHNTYGGRHAYLLPPADLPVVTAKNFYVSPFHQLAGYYLIRAPRPDRELDVTVTLHRDR FT RQVCPEFTATLRGQRRPATTRQIAMMQIISPLAPMVVAARIRIQGIRLWLRRVPVVPR" FT CDS complement(195322..196641) FT /transl_table=11 FT /locus_tag="Rv0449c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0449c, (MTV037.13c), len: 439 aa. Conserved FT hypothetical protein, some similarity with several FT hypothetical proteins and various enzymes e.g. FT AAK24569.1|AE005927 amine oxidase, flavin-containing from FT Caulobacter crescentus (454 aa); BAB02771.1|AB023036 FT mycolic acid methyl transferase-like protein from FT Arabidopsis thaliana (842 aa); BAB01742.1|AP000374 protein FT which contains similarity to cyclopropane fatty acid FT synthase from Arabidopsis thaliana (793 aa); etc. Has FT hydrophobic stretch at N-terminus. TBparse score is 0.903." FT /db_xref="GOA:O53734" FT /db_xref="InterPro:IPR002937" FT /db_xref="UniProtKB/TrEMBL:O53734" FT /protein_id="CAA17406.1" FT /translation="MQQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHAH FT THYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEMSMSVRADDIG FT LEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARLLREETDNAEDKPETLEAFL FT SRHHFSQYFVDYFITPLVAAVWSCGGADALRYPARYLFVFLDHHGMLSVFGSPTWRTVT FT GGSANYVQAIAAQLDEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQALL FT LLDEPTPAERAVLGAIAYSTNSAQLHTDESVLPRHHRARASWNYLVTPGQHQVVVSYDI FT SRLMRLDGGRRYLVTLGGHDRVDPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVF FT AGAYHGWGFHEDGAASGLRAARRLGADWPAAIPQEAMVAC" FT CDS complement(196681..199584) FT /transl_table=11 FT /gene="mmpL4" FT /locus_tag="Rv0450c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL4" FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /note="Rv0450c, (MTV037.14c), len: 967 aa. Probable mmpL4, FT conserved transmembrane transport protein (see citations FT below), member of RND superfamily, equivalent to FT U1740V|P54881|YV34_MYCLE HYPOTHETICAL 105.2 kDa PROTEIN FT from Mycobacterium leprae (959 aa), FASTA scores: opt: FT 5051, E(): 0, (78.4% identity in 962 aa overlap). Also FT highly similar to other proteins from Mycobacterium FT tuberculosis e.g. Z83860|MTCY98.08 (962 aa), FASTA scores: FT opt: 3917, E(): 0, (61.3% identity in 950 aa overlap), FT MTCY20G9.34, etc. Contains PS00211 ABC transporters family FT signature. BELONGS TO THE MMPL FAMILY. TBparse score is FT 0.948." FT /db_xref="GOA:O53735" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/Swiss-Prot:O53735" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17407.1" FT /translation="MSTKFANDSNTNARPEKPFIARMIHAFAVPIILGWLAVCVVVTVF FT VPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFAMVIIEGNQPLGDAAHKY FT YDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVE FT AVRSIVESTPAPPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSI FT ITVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRY FT QEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMPYFQTLGIPCAVGML FT VAVAVALTLGPAVLHVGSRFGLFDPKRLLKVRGWRRVGTVVVRWPLPVLVATCAIALVG FT LLALPGYKTSYNDRDYLPDFIPANQGYAAADRHFSQARMKPEILMIESDHDMRNPADFL FT VLDKLAKGIFRVPGISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDM FT LKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPI FT RSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQMVAQIPP FT QIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAAKNDDSFYLPPEVFKNK FT DFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIKSIDAIRTAAEESLKGTPLEDAKIYL FT AGTAAVFHDISEGAQWDLLIAAISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFG FT LSVLLWQHILAIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGG FT TGKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAALLGR FT WFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG" FT misc_feature complement(198538..198582) FT /note="PS00211 ABC transporters family signature" FT CDS complement(199581..200003) FT /transl_table=11 FT /gene="mmpS4" FT /locus_tag="Rv0451c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS4" FT /function="UNKNOWN" FT /note="Rv0451c, (MTV037.15c), len: 140 aa. Probable mmpS4, FT conserved membrane protein (see citations below), FT equivalent to U1740W|P54880|YV33_MYCLE HYPOTHETICAL 16.9 FT kDa PROTEIN from Mycobacterium leprae (154 aa), FASTA FT scores: opt: 727, E(): 0, (75.9% identity in 137 aa FT overlap). Also similar to other Mycobacterial proteins e.g. FT Z84725|MTCY04D9.16c from Mycobacterium tuberculosis (142 FT aa), FASTA scores: opt: 451, E(): 3.2e-24, (50.0% identity FT in 138 aa overlap); etc. BELONGS TO THE MMPS FAMILY. FT TBparse score is 0.953." FT /db_xref="GOA:P0A5K2" FT /db_xref="InterPro:IPR008693" FT /db_xref="UniProtKB/Swiss-Prot:P0A5K2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17408.1" FT /translation="MLMRTWIPLVILVVVIVGGFTVHRIRGFFGSENRPSYSDTNLENS FT KPFNPKHLTYEIFGPPGTVADISYFDVNSEPQRVDGAVLPWSLHITTNDAAVMGNIVAQ FT GNSDSIGCRITVDGKVRAERVSNEVNAYTYCLVKSA" FT CDS 200235..200945 FT /transl_table=11 FT /locus_tag="Rv0452" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0452, (MTV037.16), len: 236 aa. Possible FT transcriptional regulator, similar to several putative FT TetR-family transcriptional regulators from Streptomyces FT coelicolor. Also similar in N-terminus to FT U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67 FT aa), FASTA score: (76.1% identity in 67 aa overlap). FT Contains probable helix-turn-helix motif at aa 44-65 (Score FT 1727, +5.07 SD). TBparse score is 0.914." FT /db_xref="GOA:O53737" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:O53737" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17409.1" FT /translation="MRYPLAVAQLGFQRARTEENKRQRAAALVEAARSLALETGVASVT FT LTAVAGRAGIHYSAVRRYFTSHKEVLLHLAAEGWARWSGTVCEQLGEPGPMSAPRVAEA FT LANGLAADPLFCDLLANLHLHLEQEVDVDRVIEVKRTSIAAVIALVDAIESALPALGRS FT GAFDILLAAYSLAATLWQIANPPERLTDAYAEEPELLPPEWNLDFAAALTRLLTATLLG FT LLAGSPCECRSPTR" FT CDS 201267..202823 FT /transl_table=11 FT /gene="PPE11" FT /locus_tag="Rv0453" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0453, (MTV037.17), len: 518 aa. Member of the FT Mycobacterium tuberculosis PPE family, similar to many e.g. FT AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FT FASTA scores: opt: 882, E(): 7e-31, (41.8% identity in 514 FT aa overlap). TBparse score is 0.922." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q6MX41" FT /protein_id="CAE55282.1" FT /translation="MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGREYAAV FT AEELGALLAAVQAGVWQGPSAESFAAACLPYLSWLTQASADCAAAAARLEAVTAAYAAA FT LVAMPTLAELAANHATHGAMVATNFFGINTIPIAVNEADYVRMWLQAATTMATYQAVAD FT SAVRSIPDSVPPPRILKSNAQSQHSSSNNSGGADPVDDFIAEILKIITGGRVIWDPEAG FT TVNGLPYDAYTNPGTLMWWIARSLELLQDFQEFAKLLFTNPVKAFQFLVDLILFDWPTH FT MLQLATWLAENPQLLVAALTPAISGLGAVSGLAGLTGLVPQPPVVPAPAPDAVVPTVLP FT LAGTATPTTAPASAPAAGAAPGPPAGTATATSASVPTSAGGFPPYLVGSGPGIDFDAGT FT PAGSRRAQPAADNVTAVAAAQVSARHQARRRRRAAAKERGNADEFVDMDSGPAIPPSGE FT RDAWASNSGVGGLGFAGTASNETVAAPAGLTTLADDEFQCGPRMPMLPGAWDLGTWDRG FT D" FT CDS 202928..203278 FT /transl_table=11 FT /locus_tag="Rv0454" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0454, (MTV037.18), len: 116 aa (start uncertain). FT Conserved hypothetical protein, showing similarity with FT AAA63007.1|U15183 hypothetical protein from Mycobacterium FT leprae (115 aa), FASTA scores: opt: 151, E(): 0.0019, FT (31.5% identity in 89 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O86364" FT /protein_id="CAA17412.1" FT /translation="MKQDFGLDVPQAGNAQNFDGVPEWVQVGVVTFVYRMQMHHVTRPV FT GAPGSGLAGDSTPVQGRQRVWDLVAGRLTHAPRSSVQAMRPTMFTSAPQRHGIPARGRW FT WLGYQERSRAWP" FT CDS complement(203468..203914) FT /transl_table=11 FT /locus_tag="Rv0455c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0455c, (MTV037.19c), len: 148 aa. Conserved FT hypothetical protein, equivalent to CAC31896.1|AL583925 FT possible secreted protein from Mycobacterium leprae (153 FT aa). Has hydrophobic stretch at N-terminus. TBparse score FT is 0.947." FT /db_xref="UniProtKB/TrEMBL:O53740" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17411.1" FT /translation="MSRLSSILRAGAAFLVLGIAAATFPQSAAADSTEDFPIPRRMIAT FT TCDAEQYLAAVRDTSPVYYQRYMIDFNNHANLQQATINKAHWFFSLSPAERRDYSEHFY FT NGDPLTFAWVNHMKIFFNNKGVVAKGTEVCNGYPAGDMSVWNWA" FT CDS complement(203982..204896) FT /transl_table=11 FT /gene="echA2" FT /locus_tag="Rv0456c" FT /product="ENOYL-CoA HYDRATASE ECHA2 (ENOYL HYDRASE) FT (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING FT SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." FT /EC_number="4.2.1.17" FT /note="Rv0456c, (MTCI429A.02, MTV037.20c), len 304 aa. FT Probable echA2, enoyl-CoA hydratase (EC 4.2.1.17), similar FT to other enoyl-CoA hydratases e.g. Q13011 PEROXISOMAL FT ENOYL-CoA HYDRATASE-LIKE PROTEIN (328 aa), FASTA scores: FT opt: 209, E(): 5.3e-07, (31.7% identity in 142 aa overlap). FT Also similar to several other proteins from Mycobacterium FT tuberculosis e.g. MTCY09F9.29 FASTA score: (32.9% identity FT in 146 aa overlap); and MTI376.01c." FT /db_xref="GOA:O07179" FT /db_xref="HSSP:1MJ3" FT /db_xref="InterPro:IPR018376" FT /db_xref="UniProtKB/TrEMBL:O07179" FT /protein_id="CAB09570.1" FT /translation="MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAIGL FT AERDQDIKVIVLRGAGRAFSGGYDFGGGFQHWGDAMMTDGRWDPGKDFAMVTARETGPT FT QKFMAIWRASKPVIAQVHGWCVGGASDYALCADIVIASEDAVIGTPYSRMWGAYLTGMW FT LYRLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELARIPLSQLQ FT AQKLIVNQAYENMGLASTQLLGGILDGLMRNTPDALEFIRTAQTQGVRAAVERRDGPFG FT DYSQAPPELRPDPTHVITPDGSM" FT CDS complement(205169..205450) FT /transl_table=11 FT /locus_tag="Rv0456A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0456A, len: 93 aa. Conserved hypothetical protein; FT N-terminus highly similar to N-terminal part of FT P71650|Rv2801c|MT2869|MTCY16B7.42 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (118 aa), FASTA FT scores: opt: 303, E(): 1e-14, (60.44% identity in 91 aa FT overlap). Also some similarity in part with other FT hypothetical proteins e.g. Q9PHH8|XFA0027 Plasmid FT maintenance protein from Xylella fastidiosa (108 aa), FASTA FT scores: opt: 169, E(): 3.9e-05, (50.820% identity in 61 aa FT overlap)." FT /db_xref="GOA:Q6MX40" FT /db_xref="InterPro:IPR003477" FT /db_xref="UniProtKB/TrEMBL:Q6MX40" FT /protein_id="CAE55283.1" FT /translation="MLRGEIWQVDLDPARGSAANMRRPAVIVSNDRANAAAIRLDRGVV FT PVVPVTSNTEKVPIPGVVAGSERWPGRRFEGAGPAGWIRRCATSPLPS" FT repeat_region complement(205581..205610) FT /note="3 copies of a 10 bp near-perfect direct repeat, FT ATTACTACCTATTACTACGTATTACTATCT" FT CDS complement(205679..207700) FT /transl_table=11 FT /locus_tag="Rv0457c" FT /product="PROBABLE PEPTIDASE" FT /function="UNKNOWN; HYDROLYZES PEPTIDES AND/OR PROTEINS." FT /EC_number="3.4.-.-" FT /note="Rv0457c, (MTCI429A.01, MTV038.01c), len: 673 aa. FT Probable peptidase (EC 3.4.-.-), similar to many e.g. FT NP_102851.1|14022026|BAB48637.1 probable endopeptidase from FT Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable FT peptidase (EC 3.4.21.-) (726 aa), FASTA scores: opt: 1126, FT E(): 0, (40.9% identity in 491 aa overlap). Also similar to FT Mycobacterium tuberculosis protein MTCY369.26 FASTA score: FT (33.8% identity in 299 aa overlap)." FT /db_xref="GOA:O07178" FT /db_xref="InterPro:IPR004106" FT /db_xref="UniProtKB/TrEMBL:O07178" FT /protein_id="CAB09571.1" FT /translation="MTFEPAPDGADPYLWLEDVTGAEALDWVRARNKPTTAAFCDAEFE FT RMRVEALEVLDTDARIPYVNRRGNYLYNFWRDAANPRGLWRRTTLDSYRTDSPGWDVLI FT DVDELGRADDQKWVWGGAGVIEPDYTRALIGLSPGGSDASIVREFDMLTREFVEDGFQL FT PPAKSQITWEDPDTVLLGTDFGGDSLTTSGYPRVIKRWRRGKPLADAETIFEGAGTDVR FT VNASADRTPGFERTLLGRALDFWNEEVYELRGSELIRIEAPTDASVSIHRDWLLIELRT FT DWTVATTRYTAGSLLAAEYDEFLAGSAELQVVFEPDEHTALYQYAWTRDRLLIVTLADV FT ASRVEIATPGSWRREPLSGIPAATNTVIVSADSHGDEFFLDSSGFDTPSRLMRGTDDGR FT LAEIKSAPAFFDAENMAVTQYFATSDDGTSIPYFVVRRTDADNPGPTLLNGYGGFETSR FT TPTYDGVLGRLWLARGGTYALANIRGGGEYGPGWHTQAMREGRDKVAQDFAAVATDLVT FT RGITTAEQLGARGGSNGGLLMGIMLTGYPEKFGALVCDVPLLDMKRYHLLLAGASWMAE FT YGDPDNPDDWKFISEYSPYQNISANRKYPPVLMTTSTRDDRVHPGHARKMTAALQAAGH FT PVWYYENIEGGHAGAADNAQIAFKSALSFAFLWRMLAG" FT CDS 207768..209291 FT /transl_table=11 FT /locus_tag="Rv0458" FT /product="PROBABLE ALDEHYDE DEHYDROGENASE" FT /function="INTERCONVERSION ALDEHYDE AND ACID [CATALYTIC FT ACTIVITY: An aldehyde + NAD+ + H2O = an acid + NADH]." FT /EC_number="1.2.1.3" FT /note="Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde FT dehydrogenase (EC 1.2.1.3), highly similar to many, closest FT to P46369|THCA_RHOER EPTC-INDUCIBLE ALDEHYDE DEHYDROGENASE FT from Rhodococcus erythropolis (506 aa), FASTA scores: opt: FT 2767, E(): 0, (79.7% identity in 507 aa overlap); FT AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from FT Xanthobacter autotrophicus (505 aa), FASTA scores: opt: FT 2563, E(): 0, (75.4% identity in 492 aa overlap); FT Q9RJZ6|DHAL_STRCO PROBABLE ALDEHYDE DEHYDROGENASE from FT Streptomyces coelicolor (507 aa). Also similar to other FT semialdehyde dehydrogenases in Mycobacterium tuberculosis FT e.g. Rv0768, Rv2858c. BELONGS TO THE ALDEHYDE FT DEHYDROGENASES FAMILY. TBparse score is 0.866." FT /db_xref="GOA:P63937" FT /db_xref="HSSP:1O04" FT /db_xref="InterPro:IPR015590" FT /db_xref="UniProtKB/Swiss-Prot:P63937" FT /protein_id="CAA17413.1" FT /translation="MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVTG FT QPFCEVPRSDAADIDKALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALAVAEV FT WDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDTVAYHFHEPLGVVGQII FT PWNFPILMAAWKLAPALAAGNTAVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVNGFGA FT EAGKPLASSDRIAKVAFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHD FT DFCDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLDTETM FT LGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGTNNMRI FT FKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTAYRAGRDIQAGRVWVN FT CYHLYPAHAAFGGYKQSGIGREGHQMMLQHYQHTKNLLVSYSDKALGFF" FT CDS 209291..209782 FT /transl_table=11 FT /locus_tag="Rv0459" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0459, (MTV038.03), len: 163 aa. Conserved FT hypothetical protein, highly similar to other hypothetical FT proteins. Note that highly similar to products of FT unidentified ORFs in Xanthobacter autotrophicus, AF029733_2 FT (139 aa), and Rhodococcus erythropolis, REREUTP BC_1 (186 FT aa). Like MTV038.03, these ORF's are linked to aldehyde FT dehydrogenase genes. FASTA scores: AF0297|AF029733_2 (139 FT aa), opt: 439, E(): 6.2e-24, (50.0% identity in 126 aa FT overlap); and L24492|REREUTPBC_1 (186 aa), opt: 347, E(): FT 2.1e-17, (52.7% identity in 169 aa overlap). N-terminus FT also highly similar to AAA63041.1|U15183 ethanolamine FT permease (eutP) match from Mycobacterium leprae (53 aa). FT TBparse score is 0.894." FT /db_xref="InterPro:IPR008497" FT /db_xref="UniProtKB/TrEMBL:O53744" FT /protein_id="CAA17414.1" FT /translation="MNAPAGVLITAEAAALLAGLQDRHGPVMFHQSGGCCDGSAPMCYP FT RADFLVGDRDILLGVLDVGEDGVPVWISGPQYQAWKHTQLIIDVVPGRGGGFSLEAPEG FT VRFLSRGRVFSDAEKAMREAAPVITGAAYECGERPLVRGLVVDLDDPDATPGVCRASRR FT " FT CDS 209842..210081 FT /transl_table=11 FT /locus_tag="Rv0460" FT /product="CONSERVED HYDROPHOBIC PROTEIN" FT /function="UNKNOWN" FT /note="Rv0460, (MTV038.04), len: 79 aa. Conserved FT hydrophobic protein, highly similar AAA63024.1|U15183 FT hypothetical protein from Mycobacterium leprae (56 aa), FT FASTA scores: opt: 197, E(): 3.7e-09, (63.8% identity in 47 FT aa overlap). TBparse score is 0.896." FT /db_xref="UniProtKB/TrEMBL:O53745" FT /protein_id="CAA17415.1" FT /translation="MLVGNAIGLLAGVACSVLVHARIRPDIVIAMVVGIPSAIGLLVIL FT FSGRRWVTMLGAFILALAPGWFGVLVAIQVASSG" FT CDS 210119..210643 FT /transl_table=11 FT /locus_tag="Rv0461" FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0461, (MTV038.05), len: 174 aa (start uncertain). FT Probable transmembrane protein. TBparse score is 0.917." FT /db_xref="GOA:O53746" FT /db_xref="UniProtKB/TrEMBL:O53746" FT /protein_id="CAA17416.1" FT /translation="MPDFDTGAHSQRFLSLAGQQDRAGKSWPGSTPKPQEDPVGVAPSA FT SVEVLGSEPAATLAHSVTVPGRYTYLKWWKFVLVVLGVWIGAGEVGLSLFYWWYHTLDK FT TAAVFVVLVYVVACTVGGLILALVPGRPLITALSLGVMSGPFASVAAAAPLYGYYYCER FT MSHCLVGVIPY" FT CDS 210707..212101 FT /transl_table=11 FT /gene="lpd" FT /locus_tag="Rv0462" FT /standard_name="TB49.2" FT /product="DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE FT REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL FT DEHYDROGENASE) (DIAPHORASE)" FT /function="INVOLVED IN ENERGY METABOLISM. LIPOAMIDE FT DEHYDROGENASE IS A COMPONENT OF THE ALPHA-KETOACID FT DEHYDROGENASE COMPLEXE [CATALYTIC ACTIVITY: FT DIHYDROLIPOAMIDE + NAD(+) = LIPOAMIDE + NADH]." FT /EC_number="1.8.1.4" FT /note="Rv0462, (MTV038.06), len: 464 aa. lpd (alternate FT gene name: TB49.2), dihydrolipoamide dehydrogenase (EC FT 1.8.1.4) (see Argyrou & Blanchard 2001), equivalent to FT AAA63016.1|U15183 lipoamide dehydrogenase from FT Mycobacterium leprae (467 aa), FASTA scores: opt: 2583, FT E(): 0, (83.1% identity in 467 aa overlap). Also similar to FT to many e.g. P50970|DLDH_ZYMMO|X82291|ZMLPD_1 FT DIHYDROLIPOAMIDE DEHYDROGENASE from Z.mobilis (466 aa), FT FASTA scores: opt: 1198, E(): 0, (42.4 % identity in 465 aa FT overlap); etc. BELONG TO THE PYRIDINE NUCLEOTIDE-DISULFIDE FT OXIDOREDUCTASES CLASS-I. TBparse score is 0.897." FT /db_xref="GOA:P66004" FT /db_xref="InterPro:IPR001327" FT /db_xref="PDB:2A8X" FT /db_xref="UniProtKB/Swiss-Prot:P66004" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17417.1" FT /translation="MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVG FT CIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKN FT KITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEE FT QILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQF FT KKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKA FT GVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLG FT DHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVA FT DAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLV FT GHMINF" FT CDS 212109..212402 FT /transl_table=11 FT /locus_tag="Rv0463" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0463, (MTV038.07), len: 97 aa. Probable conserved FT transmembrane protein, highly similar to AAA63017.1|U15183 FT hypothetical protein from Mycobacterium leprae (101 aa), FT FASTA scores: opt: 364, E(): 4e-21, (57.9% identity in 95 FT aa overlap). TBparse score is 0.893." FT /db_xref="UniProtKB/TrEMBL:O53748" FT /protein_id="CAA17418.1" FT /translation="MTRRASTDTPQIIMGAIGGVVTGYILWLAAISVGDGLTTVSQWSR FT VVLLLSVLVAVCGAAGGLRLRSRGKLAWSAFAFSLPIPPVVLTVAVLADIYL" FT CDS complement(212406..212978) FT /transl_table=11 FT /locus_tag="Rv0464c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0464c, (MTV038.08c), len: 190 aa. Conserved FT hypothetical protein, highly similar to CAC31982.1|AL583925 FT conserved hypothetical protein from Mycobacterium leprae FT (188 aa). Also some similarity with FT Rv1531|AL022000|MTV045_5|D70820 hypothetical protein from FT Mycobacterium tuberculosis (188 aa), FASTA scores: E(): FT 9.6e-10, (30.9% identity in 175 aa overlap). TBparse score FT is 0.925." FT /db_xref="InterPro:IPR003779" FT /db_xref="UniProtKB/TrEMBL:O53749" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17419.1" FT /translation="MTGQNGQVARISPGKFRQLGPVNWLVAKLAARAVGAPQMHLFTTL FT GYRQYLFWTFAIYTGRLLHGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDAN FT TQATIFAWPDVPDGDGPRKVLSARQQALLQATDELIKDRTITAGTWERLATHLDPRLLI FT EFCLLATQYDAIAATITALAIPPDNPQ" FT CDS complement(212975..214399) FT /transl_table=11 FT /locus_tag="Rv0465c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0465c, (MTV038.09c), len: 474 aa. Probable FT transcriptional regulator, highly similar to FT AC44331.1|AL596102 putative DNA-binding protein from FT Streptomyces coelicolor (489 aa); and similar to several FT hypothetical proteins and others transcriptional FT regulators. Some similarity in N-terminal region (1-100 aa) FT with repressors e.g. P06153|RPC_BPPH1 IMMUNITY REPRESSOR FT PROTEIN (144 aa), FASTA scores: opt: 130, E(): 0.084,(27.0% FT identity in 100 aa overlap). Very similar to FT Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium tuberculosis FT (486 aa), FASTA scores: opt: 1475, E(): 0, (47.4% identity FT in 468 aa overlap). Contains probable helix-turn-helix FT motif at aa 19-40 (1827, +5.41 SD). TBparse score is FT 0.896." FT /db_xref="GOA:O53750" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/Swiss-Prot:O53750" FT /protein_id="CAA17420.1" FT /translation="MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPL FT TVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHPGL FT ACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHALDTA FT AEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLS FT PGQQVFKMAAELAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFH FT DVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMSKRQSAT FT GFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKT FT FAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALD FT LDEHRSTVSPYLVKQL" FT CDS 214551..215345 FT /transl_table=11 FT /locus_tag="Rv0466" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0466, (MTV038.10), len: 264 aa. Conserved FT hypothetical protein, equivalent to CAC31980.1|AL583925 FT conserved hypothetical protein from Mycobacterium leprae FT (264 aa). Similar to Rv2001|Z74025|MTCY39.17c HYPOTHETICAL FT 28.7 KDA PROTEIN from Mycobacterium tuberculosis (250 aa), FT FASTA scores: opt: 592, E(): 0, (38.0% identity in 263 aa FT overlap). Some similarity to several THIOESTERASES e.g. FT Q42561|ATACPTE17_1 ACYL-(ACYL CARRIER PROTEIN) THIOESTER FT from A. thaliana (362 aa), FASTA scores: E(): 0.0092, FT (24.4% identity in 197 aa overlap)." FT /db_xref="InterPro:IPR002864" FT /db_xref="UniProtKB/TrEMBL:O53751" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17421.1" FT /translation="MSLDKKLMPVPDGHPDVFDREWPLRVGDIDRAGRLRLDAACRHIQ FT DIGQDQLREMGFEETHPLWIVRRTMVDLIRPIEFGDMLRCRRWCSGTSNRWCEMRVRVD FT GRKGGLIESEAFWIHVNRETEMPARIADDFLAGLHRTTSVDRLRWKGYLKPGSRDDASE FT IHEFPVRVTDIDLFDHMNNAVYWSVIEDYLASHAELLRGPLRVTIEHEAPVALGDKLEI FT ISHVHPAGSTEIFGPGLVDRAVTTLTYVVGDEPKAVASLFNL" FT CDS 215620..216906 FT /transl_table=11 FT /gene="icl" FT /locus_tag="Rv0467" FT /standard_name="aceA" FT /product="ISOCITRATE LYASE ICL (ISOCITRASE) (ISOCITRATASE)" FT /function="INVOLVED IN GLYOXYLATE BYPASS (AT THE FIRST FT STEP), AN ALTERNATIVE TO THE TRICARBOXYLIC ACID CYCLE (IN FT BACTERIA, PLANTS, AND FUNGI) [CATALYTIC ACTIVITY: FT ISOCITRATE = SUCCINATE + GLYOXYLATE]. INVOLVED IN THE FT PERSISTENCE IN THE HOST." FT /EC_number="4.1.3.1" FT /note="Rv0467, (MTV038.11), len: 428 aa. icl (previously FT known as aceA), isocitrate lyase (EC 4.1.3.1) (see FT citations below), highly similar to many, closest to FT Z29367|RFISCILY_1 from R. fascians (429 aa), FASTA scores: FT opt: 2359, E(): 0, (80.7% identity in 429 aa overlap). FT BELONGS TO THE ISOCITRATE LYASE FAMILY. TBparse score is FT 0.860." FT /db_xref="GOA:P0A5H3" FT /db_xref="InterPro:IPR015813" FT /db_xref="PDB:1F61" FT /db_xref="UniProtKB/Swiss-Prot:P0A5H3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55284.1" FT /translation="MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEE FT HTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGH FT TYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALN FT VYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVP FT TVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADL FT IWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMG FT FKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA FT GYFDRIATTVDPNSSTTALTGSTEEGQFH" FT CDS 216988..217848 FT /transl_table=11 FT /gene="fadB2" FT /locus_tag="Rv0468" FT /product="PROBABLE 3-HYDROXYBUTYRYL-CoA DEHYDROGENASE FADB2 FT (BETA-HYDROXYBUTYRYL-CoA DEHYDROGENASE) (BHBD)" FT /function="BUTYRATE/BUTANOL-PRODUCING PATHWAY [CATALYTIC FT ACTIVITY: (S)-3-hydroxybutanoyl-CoA + NADP+ = FT 3-acetoacetyl-CoA + NADPH]" FT /EC_number="1.1.1.157" FT /note="Rv0468, (MTV038.12), len: 286 aa. Probable fadB2, FT 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), FT equivalent to CAC31978.1|AL583925 3-hydroxyacyl-CoA FT dehydrogenase from Mycobacterium leprae (287 aa). Also FT similar to many 3-hydroxybutyryl-CoA dehydrogenases e.g. FT U32229|BJU32229_1 beta-hydroxybutyryl coenzyme A FT dehydrogenase from Bradyrhizobium japonicum (293 aa), FASTA FT scores: opt: 771, E(): 0, (45.7% identity in 282 aa FT overlap). BELONGS TO THE 3-HYDROXYACYL-CoA DEHYDROGENASE FT FAMILY. TBparse score is 0.894." FT /db_xref="GOA:O53753" FT /db_xref="HSSP:3HDH" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O53753" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17423.1" FT /translation="MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGR FT NRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEIFA FT ELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRVLGLHFFNPVPVLPLVELVRTLVTD FT EAAAARTEEFASTVLGKQVVRCSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAV FT VAGLSHPMGPLRLSDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGR FT GFYTY" FT CDS 217981..218841 FT /transl_table=11 FT /gene="umaA" FT /locus_tag="Rv0469" FT /standard_name="umaA1" FT /product="POSSIBLE MYCOLIC ACID SYNTHASE UMAA" FT /function="Involved in mycolic acid modification or FT synthesis." FT /EC_number="2.-.-.-" FT /note="Rv0469, (MTV038.13), len: 286 aa. Possible umaA, FT mycolic acid synthase (EC 2.-.-.-) (see citations below), FT highly similar to CAC30854.1|AL583923 methyl mycolic acid FT synthase 1 from Mycobacterium leprae (286 aa); and FT CAC31976.1|AL583925 Mycolic acid synthase from FT Mycobacterium leprae (295 aa), FASTA scores: opt: 1402, FT E(): 0, (69.6% identity in 286 aa overlap). Also very FT similar to mycobacterial methyltransferases e.g. FT U77466|CmaD|MBU77466_1 (286 aa); FT MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar FT to CFA1_MYCTU|Q11195|U66108|MTU66108_1 FT cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa), FT FASTA scores: opt: 1360, E(): 0, (67.8% identity in 286 aa FT overlap) (see citation below); and very similar also to FT methoxy mycolic acid synthase 1 from Mycobacterium FT tuberculosis e.g. MTU66108_1 (286 aa). TBparse score is FT 0.944. Note that previously known as umaA1." FT /db_xref="GOA:Q6MX39" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/TrEMBL:Q6MX39" FT /protein_id="CAE55285.1" FT /translation="MTELRPFYEESQSIYDVSDEFFSLFLDPTMAYTCAYFEREDMTLE FT EAQNAKFDLALDKLHLEPGMTLLDIGCGWGGGLQRAIENYDVNVIGITLSRNQFEYSKA FT KLAKIPTERSVQVRLQGWDEFTDKVDRIVSIGAFEAFKMERYAAFFERSYDILPDDGRM FT LLHTILTYTQKQMHEMGVKVTMSDVRFMKFIGEEIFPGGQLPAQEDIFKFAQAADFSVE FT KVQLLQQHYARTLNIWAANLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGISNVGQ FT FTLTK" FT CDS complement(218941..219804) FT /transl_table=11 FT /gene="pcaA" FT /locus_tag="Rv0470c" FT /standard_name="umaA2" FT /product="MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE FT SYNTHASE)" FT /function="INVOLVED IN THE MYCOLIC ACID MODIFICATION OR FT SYNTHESIS; ESSENTIAL FOR THE CYCLOPROPANATION FUNCTION. FT REQUIRED FOR CORDING AND MYCOLIC ACID CYCLOPROPANE RING FT SYNTHESIS IN THE CELL WALL." FT /EC_number="2.-.-.-" FT /note="Rv0470c, (MTV038.14), len: 287 aa. pcaA (previously FT known as umaA2), mycolic acid synthase (cyclopropane FT synthase) (EC 2.-.-.-) (see citations below), equivalent to FT CAC31976.1|AL583925 Mycolic acid synthase from FT Mycobacterium leprae (295 aa); and highly similar to FT S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical FT protein from Mycobacterium leprae (308 aa); FT Q11195|CFA1_MYCTU CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID FT SYNTHASE 1 (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1) (287 aa) FT (see Glickman et al., 2000); U27357|MTU27357_1 cyclopropane FT mycolic acid synthase from Mycobacterium tuberculosis (287 FT aa), FASTA scores: opt: 1415, E(): 0, (72.8% identity in FT 287 aa overlap); and related enzymes e.g. FT MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa), FASTA scores: FT opt: 1387, E(): 0, (72.5% identity in 287 aa overlap). FT TBparse score is 0.893." FT /db_xref="GOA:Q7D9R5" FT /db_xref="InterPro:IPR003333" FT /db_xref="PDB:1L1E" FT /db_xref="UniProtKB/TrEMBL:Q7D9R5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55286.1" FT /translation="MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTL FT QEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAGHVQ FT KMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGHQRYHHFFEVTHRTLPADGK FT MLLHTIVRPTFKEGREKGLTLTHELVHFTKFILAEIFPGGWLPSIPTVHEYAEKVGFRV FT TAVQSLQLHYARTLDMWATALEANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQGYTDVD FT QFTLEK" FT CDS complement(219947..220387) FT /transl_table=11 FT /locus_tag="Rv0470A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0470A, len: 146 aa. Hypothetical unknown protein. FT GC plot suggests CDS for Cys-rich protein, could possibly FT be continuation of Rv0471c but no frameshift found to allow FT this. Sequence same in Mycobacterium bovis and FT Mycobacterium tuberculosis strain CDC1551. Weak hits to FT Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for FT NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt: 132, FT E(): 1.1, (39.35% identity in 61 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q8VKK9" FT /protein_id="CAE55287.1" FT /translation="MGAGGWEVVLASLPYGLLCTTVLMGKHIDKIGYDEPLGIRTLPVL FT LGETCARTVTLAMMVGFYLLIAVNVMLAAMPWPRCWSPGRCPGWRKCGPISCDGGPSSR FT HRRFRCGRCGMPRWPGCTCVRPVRCWLWAWRSVPGGAPGDFR" FT CDS complement(220318..220806) FT /transl_table=11 FT /locus_tag="Rv0471c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0471c, (MTV038.15c), len: 162 aa. Hypothetical FT unknown protein. TBparse score is 0.937." FT /db_xref="UniProtKB/TrEMBL:O53756" FT /protein_id="CAA17426.1" FT /translation="MPDAGAGSRLRSWAYALRTTNPPADGPTDTVTRWLVVTRAAVLPM FT TLVSGLVAGLLAIGEPGLDWRWLVLWWESHAPHIANNLMNDLYDTDVGTDSATYARARY FT AQHPAATGANRAAYTTPRRTTSCGSPERALEPTTPRWARAVGRSCWRRSPTGCCAPRC" FT CDS complement(220816..221520) FT /transl_table=11 FT /locus_tag="Rv0472c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0472c, (MTV038.16c), len: 234 aa. Probable FT regulatory protein, possibly tetR family, equivalent to FT CAC31974.1|AL583925 possible TetR-family transcriptional FT regulator from Mycobacterium leprae (233 aa). Also similar FT to CAC01492.1|AL391017 putative transcriptional regulatory FT protein from Streptomyces coelicolor (218 aa); and FT CAC01371.1|AL390975 putative tetR-family transcriptional FT regulator from Streptomyces coelicolor (228 aa). Also FT similar to AL0212|MTV012_65 from Mycobacterium tuberculosis FT (246 aa), FASTA scores: opt: 327, E(): 1.8e-15, (31.0% FT identity in 232 aa overlap); and Z95120|MTCY07D11.18c (228 FT aa), FASTA scores: opt: 190, E(): 4.4e-06, (23.1% identity FT in 186 aa overlap). Contains probable helix-turn-helix FT doimain at aa 45-66 (Score 1429, +4.05 SD). TBparse score FT is 0.898." FT /db_xref="GOA:O53757" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:O53757" FT /protein_id="CAA17427.1" FT /translation="MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRFL FT SMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGFELTRE FT IIRVYVETVAAQPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMDTGG FT VEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKFREQP FT HPSPIVPAWGQV" FT CDS 221657..223027 FT /transl_table=11 FT /locus_tag="Rv0473" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0473, (MTV038.17), len: 456 aa. Possible conserved FT transmembrane protein, showing some similarity to FT hypothetical proteins e.g. FT NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical FT protein from Mesorhizobium loti (431 aa); FT P39385|YJIN_ECOLI|YJIN|B4336 HYPOTHETICAL 48.2 kDa PROTEIN FT (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli FT strain K12 (426 aa), FASTA scores: opt: 396, E(): 9.8e-19, FT (31.8 % identity in 424 aa overlap); etc. TBparse score is FT 0.899." FT /db_xref="GOA:O53758" FT /db_xref="InterPro:IPR007383" FT /db_xref="UniProtKB/TrEMBL:O53758" FT /protein_id="CAA17428.1" FT /translation="MVAHKAEVSGSPPPRLNLSTQPTVARRVRASFAESFAAADPEADA FT ARRMALRRMKVVAVGFLVGATGVFLACRWAQADGADHAWLGYLGAAAEAGMVGALADWF FT AVTALFKHPLGIPIPHTAIIKRKKDQLGEGLGTFVRENFLSPPVVETKLRDAQIPSRLG FT KWLSEATHAQRVAAETATVLRVLVELLRDEDIQQVIDRMIVRRIAEPQWGPPAGRVLAT FT LLAENRQEAFIQLLADRAFQWSLNAGVVIQRVVERDSPSWSPRFIDHLVGDRIHRELME FT FTDKVRRNPDHELRRSATRFLFDFADDLQHDPATVARADAIKEELMARDEIATAAAAAW FT KTLKRLVLEGVDDPSSALRTRITDAVIRIGESLRDDADLRDKVDSWTVRAAQHLVSEYG FT VEITAIITETIERWDAEEASRRIELHVGRDLQFIRINGTVVGAMAGLAIYAIAQLLF" FT CDS 223114..223536 FT /transl_table=11 FT /locus_tag="Rv0474" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0474, (MTV038.18), len: 140 aa. Probable FT transcriptional regulator, highly similar to others e.g. FT CAC04034.1|AL391406 putative DNA-binding protein from FT Streptomyces coelicolor (141 aa); N-terminus of FT NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional FT regulator from Mesorhizobium loti (219 aa); N-terminus of FT A83618|PA0225 probable transcription regulator from FT Pseudomonas aeruginosa (179 aa); SINR_BACSU|P06533 sinr FT protein from Bacillus subtilis (111 aa), FASTA scores: opt: FT 147, E(): 8.9e-06, (30.6% identity in 111 aa overlap). Also FT similar to other hypothetical proteins e.g. FT X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa), FASTA FT scores: opt: 280, E(): 4.8e-12, (43.6% identity in 117 aa FT overlap). Also similar to Rv2745c from Mycobacterium FT tuberculosis. Contains probable helix-turn-helix domain at FT aa 35-56 (Score 1709, +5.01 SD). TBparse score is 0.903." FT /db_xref="GOA:O53759" FT /db_xref="HSSP:1B0N" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/Swiss-Prot:O53759" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17429.1" FT /translation="MSSEEKLAAKVSTKASDVASDIGSFIRSQRETAHVSMRQLAERSG FT VSNPYLSQVERGLRKPSADVLSQIAKALRVSAEVLYVRAGILEPSETSQVRDAIITDTA FT ITERQKQILLDIYASFTHQNEATREECPSDPTPTDD" FT CDS 223890..224489 FT /transl_table=11 FT /gene="hbhA" FT /locus_tag="Rv0475" FT /product="IRON-REGULATED HEPARIN BINDING HEMAGGLUTININ HBHA FT (ADHESIN)" FT /function="REQUIRED FOR EXTRAPULMONARY DISSEMINATION. FT MEDIATES ADHERENCE TO EPITHELIAL CELLS BY BINDING TO FT SULFATED GLYCOCONJUGATES PRESENT AT THE SURFACE OF THESE FT CELLS; BINDS HEPARIN, DEXTRAN SULFATE, FUCOIDAN AND FT CHONDROITIN SULFATE. PROMOTES HEMAGGLUTINATION OF FT ERYTHROCYTES OF CERTAIN HOST SPECIES. INDUCES MYCOBACTERIAL FT AGGREGATION." FT /note="Rv0475, hbhA (MTCY20G9.01), len: 199 aa. hbhA, FT iron-regulated heparin-binding hemagglutinin (see citations FT below), equivalent to CAC31971.1|AL583925 possible FT hemagglutinin from Mycobacterium leprae (188 aa). Contains FT possible N-terminal signal sequence and K-A-rich region at FT C-terminus: SUBCELLULAR LOCATION: SURFACE ASSOCIATED." FT /db_xref="GOA:P0A5P6" FT /db_xref="UniProtKB/Swiss-Prot:P0A5P6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB00936.1" FT /translation="MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTD FT TRSRVEESRARLTKLQEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERGEA FT ALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPKKA FT APAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK" FT CDS 224601..224864 FT /transl_table=11 FT /locus_tag="Rv0476" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0476, (MTCY20G9.02), len: 87 aa. Possible FT conserved transmembrane protein, equivalent to FT CAC31970.1|AL583925 conserved membrane protein from FT Mycobacterium leprae (95 aa). Also highly similar to FT CAC04036.1|AL391406 putative membrane protein from FT Streptomyces coelicolor (113 aa). Contains PS00606 FT Beta-ketoacyl synthases active site." FT /db_xref="GOA:P64695" FT /db_xref="InterPro:IPR019662" FT /db_xref="UniProtKB/Swiss-Prot:P64695" FT /protein_id="CAB00937.1" FT /translation="MLVLLVAVLVTAVYAFVHAALQRPDAYTAADKLTKPVWLVILGAA FT VALASILYPVLGVLGMAMSACASGVYLVDVRPKLLEIQGKSR" FT misc_feature 224769..224819 FT /note="PS00606 Beta-ketoacyl synthases active site" FT CDS 224869..225315 FT /transl_table=11 FT /locus_tag="Rv0477" FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0477, (MTCY20G9.03), len: 148 aa. Possible FT conserved secreted protein, equivalent to FT CAC31969.1|AL583925 hypothetical protein from Mycobacterium FT leprae (123 aa). Also similar to G83406|PA1914 conserved FT hypothetical protein from Pseudomonas aeruginosa (408 aa). FT Contains possible N-terminal signal sequence." FT /db_xref="InterPro:IPR019719" FT /db_xref="UniProtKB/Swiss-Prot:P64697" FT /protein_id="CAB00938.1" FT /translation="MKALVAVSAVAVVALLGVSSAQADPEADPGAGEANYGGPPSSPRL FT VDHTEWAQWGSLPSLRVYPSQVGRTASRRLGMAAADAAWAEVLALSPEADTAGMRAQFI FT CHWQYAEIRQPGKPSWNLEPWRPVVDDSEMLASGCNPGSPEESF" FT CDS 225315..225989 FT /transl_table=11 FT /gene="deoC" FT /locus_tag="Rv0478" FT /product="PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC FT (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE)" FT /function="INVOLVED IN NUCLEOTIDE AND DEOXYRIBONUCLEOTIDE FT CATABOLISM [CATALYTIC ACTIVITY: 2-deoxy-D-ribose FT 5-phosphate = D-glyceraldehyde 3-phosphate + FT acetaldehyde]." FT /EC_number="4.1.2.4" FT /note="Rv0478, (MTCY20G9.04), len: 224 aa. Probable deoC, FT deoxyribose-phosphate aldolase (EC 4.1.2.4), equivalent to FT Q9CB45|DEOC_MYCLE DEOXYRIBOSE-PHOSPHATE ALDOLASE from FT Mycobacterium leprae (226 aa). Also highly similar to FT others e.g. DEOC_BACSU|P39121 from Bacillus subtilis (214 FT aa), FASTA scores: opt: 543, E(): 1.4e-26, (45.9% identity FT in 209 aa overlap); etc. BELONGS TO THE DEOC/FBAB FAMILY OF FT ALDOLASES, DEOC SUBFAMILY." FT /db_xref="GOA:P63929" FT /db_xref="HSSP:1O0Y" FT /db_xref="InterPro:IPR002915" FT /db_xref="UniProtKB/Swiss-Prot:P63929" FT /protein_id="CAB00939.1" FT /translation="MLGQPTRAQLAALVDHTLLKPETTRADVAALVAEAAELGVYAVCV FT SPSMVPVAVQAGGVRVAAVTGFPSGKHVSSVKAHEAAAALASGASEIDMVIDIGAALCG FT DIDAVRSDIEAVRAAAAGAVLKVIVESAVLLGQSNAHTLVDACRAAEDAGADFVKTSTG FT CHPAGGATVRAVELMAETVGPRLGVKASGGIRTAADAVAMLNAGATRLGLSGTRAVLDG FT LS" FT CDS complement(226014..227060) FT /transl_table=11 FT /locus_tag="Rv0479c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0479c, (MTCY20G9.04c), len: 348 aa. Probable FT conserved membrane protein, equivalent to FT CAC31967.1|AL583925 possible secreted protein from FT Mycobacterium leprae (254 aa); and C-terminus highly FT similar to AAF74996.1|AF143402_1|AF143402 putative FT multicopper oxidase from Mycobacterium avium (149 aa). FT Contains hydrophobic domain in centre of protein." FT /db_xref="GOA:P64699" FT /db_xref="UniProtKB/Swiss-Prot:P64699" FT /protein_id="CAB00940.1" FT /translation="MTNPQGPPNDPSPWARPGDQGPLARPPASSEASTGRLRPGEPAGH FT IQEPVSPPTQPEQQPQTEHLAASHAHTRRSGRQAAHQAWDPTGLLAAQEEEPAAVKTKR FT RARRDPLTVFLVLIIVFSLVLAGLIGGELYARHVANSKVAQAVACVVKDQATASFGVAP FT LLLWQVATRHFTNISVETAGNQIRDAKGMQIKLTIQNVRLKNTPNSRGTIGALDATITW FT SSEGIKESVQNAIPILGAFVTSSVVTHPADGTVELKGLLNNITAKPIVAGKGLELQIIN FT FNTLGFSLPKETVQSTLNEFTSSLTKNYPLGIHADSVQVTSTGVVSRFSTRDAAIPTGI FT QNPCFSHI" FT CDS complement(227057..227899) FT /transl_table=11 FT /locus_tag="Rv0480c" FT /product="POSSIBLE AMIDOHYDROLASE" FT /function="UNKNOWN; HYDROLYTIC ENZYME PROBABLY INVOLVED IN FT CELLULAR METABOLISM." FT /EC_number="3.-.-.-" FT /note="Rv0480c, (MTCY20G9.06c), len: 280 aa. Possible FT amidohydrolase (EC 3.-.-.-), highly similar to FT NP_302587.1|NC_002677|CAC31966.1|AL583925 putative FT hydrolase from Mycobacterium leprae (271 aa). Also similar FT to other hydrolases and hypothetical proteins e.g. FT NP_601985.1|NC_003450 Predicted amidohydrolase from FT Corynebacterium glutamicum (266 aa); NP_459623.1|NC_003197 FT putative hydrolase from Salmonella typhimurium LT2 (262 FT aa); AL096822|SCGD3_8|NP_627996.1|NC_003888 probable FT hydrolase from Streptomyces coelicolor (264 aa), FASTA FT scores: opt: 368, E(): 6.1e-15, (34.2% identity in 272 aa FT overlap); YAUB_SCHPO|Q10166 hypothetical 35.7 kDa protein FT c26a3.11 from S. pombe (322 aa), FASTA scores: opt: 338, FT E():1.4e-13, (30.3% identity in 277 aa overlap); etc. Start FT changed since first submission (-60 aa)." FT /db_xref="GOA:Q11146" FT /db_xref="HSSP:1EMS" FT /db_xref="InterPro:IPR001110" FT /db_xref="UniProtKB/Swiss-Prot:Q11146" FT /protein_id="CAB00941.2" FT /translation="MRIALAQIRSGTDPAANLQLVGKYAGEAATAGAQLVVFPEATMCR FT LGVPLRQVAEPVDGPWANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPNQP FT DAHYHKIHLYDAFGFTESRTVAPGREPVVVVVDGVRVGLTVCYDIRFPALYTELARRGA FT QLIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGDARTGVGASSAAPTGV FT GGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAAARDRIAVLRNQTDFVQIDKAQSRG" FT CDS complement(228081..228605) FT /transl_table=11 FT /locus_tag="Rv0481c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0481c, (MTCY20G9.07c), len: 174 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR019639" FT /db_xref="UniProtKB/Swiss-Prot:P64701" FT /protein_id="CAB00942.1" FT /translation="MPRSFDMSADYEGSVEEVHRAFYEADYWKARLAETPVDVATLESI FT RVGGDSGDDGTIEVVTLQMVRSHNLPGLVTQLHRGDLSVRREETWGPVKEGIATASIAG FT SIVDAPVNLWGTAVLSPIPESGGSRMTLQVTIQVRIPFIGGKLERLIGTQLSQLVTIEQ FT RFTTLWITNNV" FT CDS 228632..229741 FT /transl_table=11 FT /gene="murB" FT /locus_tag="Rv0482" FT /product="PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE FT REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE)" FT /function="INVOLVED IN CELL WALL FORMATION; PEPTIDOGLYCAN FT BIOSYNTHESIS [CATALYTIC ACTIVITY: UDP-N-acetylmuramate + FT NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + FT NADPH]." FT /EC_number="1.1.1.158" FT /note="Rv0482, (MTCY20G9.08), len: 369 aa. Probable murB, FT UDP-N-acetylenolpyruvoylglucosamine reductase (EC FT 1.1.1.158) (see citation below), equivalent to FT CAC31964.1|AL583925 UDP-N-acetylenolpyruvoylglucosamine FT reductase from Mycobacterium leprae (367 aa). Also highly FT similar to others e.g. MURB_ECOLI|P08373 FT UDP-N-acetylenolpyruvoylglucosamine reductase from FT Escherichia coli (342 aa), FASTA scores: opt: 292, E(): FT 6.3e-12, (33.5% identity in 355 aa overlap); etc. BELONGS FT TO THE MURB FAMILY. COFACTOR: FAD." FT /db_xref="GOA:P65460" FT /db_xref="HSSP:2MBR" FT /db_xref="InterPro:IPR006094" FT /db_xref="UniProtKB/Swiss-Prot:P65460" FT /protein_id="CAB00943.1" FT /translation="MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQV FT VAALRHLDSAAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGNLVRAEAGA FT VFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLDRCTGEV FT RWVSARDLRFGYRTSVLKHADGLAVPTVVLEVEFALDPSGRSAPLRYGELIAALNATSG FT ERADPQAVREAVLALRARKGMVLDPTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKD FT GPVPHYPAPDGVKLAAGWLVERAGFGKGYPDAGAAPCRLSTKHALALTNRGGATAEDVV FT TLARAVRDGVHDVFGITLKPEPVLIGCML" FT CDS 229803..231158 FT /transl_table=11 FT /gene="lprQ" FT /locus_tag="Rv0483" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRQ" FT /function="UNKNOWN" FT /note="Rv0483, (MTCY20G9.09), len: 451 aa. Probable lprQ, FT conserved lipoprotein, equivalent to FT CAC31963.1|AL583925|ML2446 possible lipoprotein from FT Mycobacterium leprae (441 aa); appears longer than ML2446, FT so start may be further downstream. Shows also similarity FT with MLCL383_24|O07707 HYPOTHETICAL 43.6 kDa PROTEIN from FT Mycobacterium leprae; and to Q49706|B1496_F2_81 (271 aa). FT Similar to others lipoproteins from other organisms. Also FT similar to several Mycobacterium tuberculosis hypothetical FT proteins e.g. Rv0116c, Rv0192, Rv1433, Rv2518c. Contains FT potential N-terminal signal sequence and appropriately FT positioned PS00013 prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:P64703" FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/Swiss-Prot:P64703" FT /protein_id="CAB00944.1" FT /translation="MVIRVLFRPVSLIPVNNSSTPQSQGPISRRLALTALGFGVLAPNV FT LVACAGKVTKLAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGK FT VVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKAVPVAGKFTTVAPVKTINAGFQ FT LADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDEAQGARVHWRP FT REYYPAGTTVDVDAKLYGLPFGDGAYGAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAG FT VIMDFPCSYGEADLARNVTRNGIHVVTEKYSDFYMSNPAAGYSHIHERWAVRISNNGEF FT IHANPMSAGAQGNSNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYADGDIWD FT WAVDWDTWVSMSALPPPAAKPAATQIPVTAPVTPSDAPTPSGTPTTTNGPGG" FT CDS complement(231139..231894) FT /transl_table=11 FT /locus_tag="Rv0484c" FT /product="PROBABLE SHORT-CHAIN TYPE OXIDOREDUCTASE" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable FT short-chain oxidoreductase (EC 1.-.-.-), highly similar to FT others e.g. T36118|4678912|CAB41284.1|AL049707 probable FT oxidoreductase from Streptomyces coelicolor (260 aa); FT YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR FT family) from Haemophilus influenzae (252 aa), FASTA scores: FT opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa FT overlap); etc. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY. STRONG SIMILARITY, FT TO BACTERIAL YDFG HOMOLOGS." FT /db_xref="GOA:Q11150" FT /db_xref="HSSP:1FDU" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:Q11150" FT /protein_id="CAB00945.1" FT /translation="MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRI FT TALANQIGGTAIVADVTDDAAVEALARALSRVDVLVNNAGGAKGLQFVADADLEHWRWM FT WDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALHRTL FT RGELLGKPVRLTEIAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVAT FT RPSHVNLDQIVIRPRDQASASRRATHPVR" FT CDS 232077..233393 FT /transl_table=11 FT /locus_tag="Rv0485" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0485, (MTCY20G9.11), len: 438 aa. Possible FT transcriptional repressor, member of the NAGC/XYLR FT repressor FAMILY; similar to several e.g. FT D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor FT from Vibrio cholerae (404 aa), FASTA scores: opt: 378, E(): FT 1.2e-17, (26.9% identity in 350 aa overlap); FT NAGC_ECOLI|P15301 N-acetylglucosamine repressor from FT Escherichia coli (406 aa), FASTA scores: opt: 305, E(): FT 1.8e-12, (21.8% identity in 357 aa overlap); etc." FT /db_xref="InterPro:IPR000600" FT /db_xref="UniProtKB/Swiss-Prot:P64705" FT /protein_id="CAB00946.1" FT /translation="MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAAASVFRA FT VRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAVSGAIGRPRVPVEVNH FT EPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTPRNAAGAALTSLADSADRYLQRWRR FT RRALWVGVTLGGAVDSATGHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMAGAEL FT MLGMRRFAPSSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLGGTGQL FT ESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQQAKELLAERARV FT LGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAFTAGSVLAPRDIRVTVFGNRVQ FT EAGAGIVSLSGLYADPLGALRRSGALDARLQDTAPEALA" FT CDS 233441..234883 FT /transl_table=11 FT /locus_tag="Rv0486" FT /product="MANNOSYLTRANSFERASE" FT /function="THOUGHT TO BE INVOLVED IN POLYPRENOLMANNOSE FT SYNTHESIS." FT /EC_number="2.4.1.-" FT /note="Rv0486, (MTCY20G9.12), len: 480 aa. FT Mannosyltransferase (EC 2.4.1.-) (see citations below), FT highly similar to P54138|Y486_MYCLE|ML2443 possible FT glycosyl transferase from Mycobacterium leprae (428 aa); FT and S72892|B2168_C2_201 probable hexosyltransferase (EC FT 2.4.1.-) from Mycobacterium leprae (409 aa), FASTA scores: FT opt: 2375, E(): 0, (86.4% identity in 413 aa overlap). Also FT highly similar to CAC04040.1|AL391406 putative transferase FT from Streptomyces coelicolor (496 aa); and similar to FT various transferases e.g. NP_437172.1|NC_003078 putative FT membrane-anchored glycosyltransferase protein from FT Sinorhizobium meliloti (416 aa); O26550|U67601_1 LPS FT BIOSYNTHESIS RELATED PROTEIN from Methanococcus jannaschii FT (411 aa), FASTA score: (25.3% identity in 387 aa overlap); FT etc. Also similar to CAC87824.1|AJ316594 putative FT sucrose-phosphate synthase from Nostoc punctiforme (422 FT aa). Contains PS00039 DEAD-box subfamily ATP-dependent FT helicases signature." FT /db_xref="GOA:P64707" FT /db_xref="InterPro:IPR017814" FT /db_xref="UniProtKB/Swiss-Prot:P64707" FT /protein_id="CAB00947.1" FT /translation="MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPR FT RVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVRVA FT PGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQVGW FT LARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEAR FT QVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPD FT IVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLF FT RAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQWA FT DAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNAERQRRGGE FT VISDLVAVGKPRHWTPRRGVGA" FT misc_feature 234056..234082 FT /note="PS00039 DEAD-box subfamily ATP-dependent helicases FT signature" FT CDS 234880..235431 FT /transl_table=11 FT /locus_tag="Rv0487" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0487, (MTCY20G9.13), len: 183 aa. Conserved FT hypothetical protein, highly similar to FT P54139|Y487_MYCLE|U00018_38|ML2442 HYPOTHETICAL 20.8 KDA FT PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: FT opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa FT overlap). Also highly similar to CAC04041.1|AL391406 FT conserved hypothetical protein from Streptomyces coelicolor FT (168 aa)." FT /db_xref="InterPro:IPR019706" FT /db_xref="UniProtKB/Swiss-Prot:P64709" FT /protein_id="CAB00948.1" FT /translation="MTSSLPTVQRVIQNALEVSQLKYSQHPRPGGAPPALIVELPGERK FT LKINTILSVGEHSVRVEAFVCRKPDENREDVYRFLLRRNRRLYGVAYTLDNVGDIYLVG FT QMALSAVDADEVDRVLGQVLEVVDSDFNALLELGFRSSIQREWQWRLSRGESLQNLQAF FT AHLRPTTMQSAQRDEKELGG" FT CDS 235757..236362 FT /transl_table=11 FT /locus_tag="Rv0488" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF FT LYSINE ACROSS THE MEMBRANE." FT /note="Rv0488, (MTCY20G9.14), len: 201 aa. Probable FT conserved integral membrane protein, LysE family possibly FT involved in transport of Lysine, similar to others and FT conserved hypothetical proteins e.g. AB93746.1|AL357613 FT putative membrane transport protein from Streptomyces FT coelicolor (204 aa); D83100|PA4365 probable transporter FT from Pseudomonas aeruginosa (200 aa); YGGA_ECOLI|P11667 FT hypothetical 21.7 kDa protein from Escherichia coli (197 FT aa), FASTA scores: opt: 382, E(): 1.1e-19, (39.1% identity FT in 179 aa overlap); CGLYSEG_2 C|P94633 LYSINE EXPORTER FT PROTEIN (236 aa), FASTA scores: E(): 2.3e-07, (33.3% FT identity in 219 aa overlap). Also similar to Rv1986 from FT Mycobacterium tuberculosis." FT /db_xref="GOA:P64711" FT /db_xref="InterPro:IPR001123" FT /db_xref="UniProtKB/Swiss-Prot:P64711" FT /protein_id="CAB00949.1" FT /translation="MMTLKVAIGPQNAFVLRQGIRREYVLVIVALCGIADGALIAAGVG FT GFAALIHAHPNMTLVARFGGAAFLIGYALLAARNAWRPSGLVPSESGPAALIGVVQMCL FT VVTFLNPHVYLDTVVLIGALANEESDLRWFFGAGAWAASVVWFAVLGFSAGRLQPFFAT FT PAAWRILDALVAVTMIGVAVVVLVTSPSVPTANVALII" FT CDS 236519..237268 FT /transl_table=11 FT /gene="gpm1" FT /locus_tag="Rv0489" FT /standard_name="gpm" FT /product="PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 FT (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)" FT /function="INVOLVED IN GLYCOLYSIS [CATALYTIC ACTIVITY: FT 1,3-DIPHOSPHOGLYCERATE + 3-PHOSPHOGLYCERATE = FT 2,3-DIPHOSPHOGLYCERATE + 3-PHOSPHOGLYCERATE]." FT /EC_number="5.4.2.1" FT /note="Rv0489, (MTCY20G9.15), len: 249 aa. Probable gpm1, FT phosphoglycerate mutase 1 (EC 5.4.2.1), equivalent to FT P53531|PMGY_MYCLE PHOSPHOGLYCERATE MUTASE from FT Mycobacterium leprae (247 aa). Also highly similar to FT others e.g. PMG1_ECOLI|P31217 (249 aa), FASTA scores: opt: FT 805, E(): 0, (51.4% identity in 245 aa overlap); etc. FT Contains PS00175 Phosphoglycerate mutase family FT phosphohistidine signature, and PS00017 ATP/GTP-binding FT site motif A (P-loop). BELONGS TO THE PHOSPHOGLYCERATE FT MUTASE FAMILY. Note that previously known as gpm." FT /db_xref="GOA:P0A5R6" FT /db_xref="InterPro:IPR005952" FT /db_xref="PDB:1RII" FT /db_xref="UniProtKB/Swiss-Prot:P0A5R6" FT /protein_id="CAE55288.1" FT /translation="MANTGSLVLLRHGESDWNALNLFTGWVDVGLTDKGQAEAVRSGEL FT IAEHDLLPDVLYTSLLRRAITTAHLALDSADRLWIPVRRSWRLNERHYGALQGLDKAET FT KARYGEEQFMAWRRSYDTPPPPIERGSQFSQDADPRYADIGGGPLTECLADVVARFLPY FT FTDVIVGDLRVGKTVLIVAHGNSLRALVKHLDQMSDDEIVGLNIPTGIPLRYDLDSAMR FT PLVRGGTYLDPEAAAAGAAAVAGQGRG" FT misc_feature 236543..236572 FT /note="PS00175 Phosphoglycerate mutase family FT phosphohistidine signature" FT misc_feature 237026..237049 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 237442..238674 FT /transl_table=11 FT /gene="senX3" FT /locus_tag="Rv0490" FT /product="PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE FT SENX3" FT /function="SENSOR PART OF A TWO COMPONENT REGULATORY FT SYSTEM. PROBABLY FORMS PART OF A TWO-COMPONENT REGULATORY FT SYSTEM SENX3/REGX3; PHOSPHORYLATES REGX3." FT /EC_number="2.7.3.-" FT /note="Rv0490, (MTCY20G9.16), len: 410 aa. Putative senX3, FT two-component sensor histidine kinase (EC 2.7.3.-), FT transmembrane protein (see citations below), equivalent to FT O07129|SEX3_MYCBO SENSOR-LIKE HISTIDINE KINASE SENX3 from FT Mycobacterium bovis BCG (410 aa), FASTA scores: E(): 0, FT (99.5% identity in 410 aa overlap); and highly similar to FT P54883|SEX3_MYCLE|SENX3 SENSOR-LIKE HISTIDINE KINASE from FT Mycobacterium leprae (443 aa), FASTA score: (83.8% identity FT in 408 aa overlap). Also highly similar, except in FT N-terminus, to CAC31957.1|AL583925 probable two-component FT system sensor histidine kinase from Mycobacterium leprae FT (441 aa). Also highly similar to sensor kinase proteins FT from other organisms e.g. CAB77323.1|AL160331 putative FT sensor kinase protein from Streptomyces coelicolor (426 FT aa)." FT /db_xref="GOA:P0A600" FT /db_xref="InterPro:IPR005467" FT /db_xref="UniProtKB/Swiss-Prot:P0A600" FT /protein_id="CAB00951.1" FT /translation="MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSG FT ITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGG FT EDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVA FT NVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQG FT AERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLV FT SNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATG FT GSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRS FT NRSQREEELSR" FT repeat_region 238671..238747 FT /note="77 bp Mycobacterial Interspersed Repetitive Unit, FT Class I. See citation below." FT repeat_region 238748..238824 FT /note="77 bp Mycobacterial Interspersed Repetitive Unit, FT Class I. See citation below." FT repeat_region 238825..238901 FT /note="77 bp Mycobacterial Interspersed Repetitive Unit, FT Class I. See citation below." FT CDS 238902..239585 FT /transl_table=11 FT /gene="regX3" FT /locus_tag="Rv0491" FT /product="TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 FT (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY FT LUXR-FAMILY)" FT /function="TRANSCRIPTIONAL REGULATORY PROTEIN PART OF THE FT TWO COMPONENT REGULATORY SYSTEM REGX3/SENX3." FT /note="Rv0491, (MTCY20G9.17), len: 227 aa. regX3, response FT regulator protein (sensory transduction protein) (see FT citations below), equivalent to O07130|RGX3_MYCBO|REGX3 FT SENSORY TRANSDUCTION PROTEIN from Mycobacterium bovis BCG FT (227 aa); AAG09797.1|AF258346_2|AF258346|REGX3 response FT regulator from Mycobacterium smegmatis (228 aa); equivalent FT to P54884|RGX3_MYCLE|REGX3 SENSORY TRANSDUCTION PROTEIN FT from Mycobacterium leprae (198 aa), FASTA scores : E(): 0, FT (95.4% identity in 197 aa overlap). Also highly similar to FT other response regulators e.g. AAG43239.1|AF123314_2 FT |AF123314 putative response regulator from Corynebacterium FT glutamicum (232 aa)." FT /db_xref="GOA:Q11156" FT /db_xref="InterPro:IPR011991" FT /db_xref="PDB:2OQR" FT /db_xref="UniProtKB/Swiss-Prot:Q11156" FT /protein_id="CAB00952.1" FT /translation="MTSVLIVEDEESLADPLAFLLRKEGFEATVVTDGPAALAEFDRAG FT ADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVTKPYS FT ARELIARIRAVLRRGGDDDSEMSDGVLESGPVRMDVERHVVSVNGDTITLPLKEFDLLE FT YLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLG FT YKLEG" FT CDS complement(239582..241471) FT /transl_table=11 FT /locus_tag="Rv0492c" FT /product="PROBABLE OXIDOREDUCTASE GMC-TYPE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0492c, (MT0511/MT0512, MTCY20G9.18c), len: 629 aa. FT Probable oxidoreductase GMC type (EC 1.-.-.-), similar to FT others except in N-terminus e.g. FT P55582|AE000087_5|Y4NJ_RHISN HYPOTHETICAL GMC-TYPE FT OXIDOREDUCTASE from Rhizobium sp. (505 aa), FASTA scores: FT opt: 873, E():0, (34.3% identity in 502 aa overlap); FT YTH2_RHOER|P46371 HYPOTHETICAL 53.0 kDa GMC-TYPE FT OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa), FT FASTA score: (25.7% identity in 521 aa overlap); FT YTH2_RHOSO|P46371 hypothetical 53.0 kDa gmc-type FT oxidoreductase from Rhodococcus erythropolis (493 aa), FT FASTA score: (25.7% identity in 521 aa overlap); FT NP_085596.1|NC_002679 probable oxidoreductase from FT Mesorhizobium loti (507 aa); NP_285451.1|NC_001264 GMC FT oxidoreductase from Deinococcus radiodurans (722 aa); FT NP_249055.1|NC_002516 probable oxidoreductase from FT Pseudomonas aeruginosa (531 aa); etc. Contains PS00198 FT 4Fe-4S ferredoxins, iron-sulfur binding region signature, FT and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE FT GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD (BY SIMILARITY). FT Note that start changed since first submission (previously FT 684 aa)." FT /db_xref="GOA:Q11157" FT /db_xref="InterPro:IPR007867" FT /db_xref="UniProtKB/Swiss-Prot:Q11157" FT /protein_id="CAB00953.2" FT /translation="MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLP FT ATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERARVLHRIAALSPEVAAAVEGLKAIV FT LLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAMVAR FT TLARAGLDVVVLEEGRRWTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMGRAVG FT GTTVVNSGTCFRPSLAVQRRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRN FT GRLLLQAAKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGARII FT SWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSGLGGHPRL FT GHNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESDGVLIEATSTPPGMGSMVFPG FT YGAELLRWLDRAPQIATFGAMVADRGVGTVRSVRGETVVRYDIAPGEIAKLRVALQAIG FT RLLFAAGAVEVLTGIPGAPPMRSLPELQDVLRRANPRSLHLAAFHPTGTAAAGADEQLC FT PVDATGRLRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR" FT misc_feature complement(240290..240334) FT /note="PS00624 GMC oxidoreductases signature 2" FT misc_feature complement(240521..240556) FT /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding FT region signature" FT CDS complement(241468..241797) FT /transl_table=11 FT /locus_tag="Rv0492A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0492A, len: 109 aa. Hypothetical unknown protein. FT GC plot suggests CDS." FT /db_xref="UniProtKB/TrEMBL:Q6MX36" FT /protein_id="CAE55289.1" FT /translation="MSFLLDPPLLFVCGVLIERRLPVDRRDAAEAAALGVFFGASFGLY FT HNVPGLGMLWRPFRAQNGRDFMWNSGVFSVDVARAEWPLHAMAAAIFATYPFFIKLGRR FT LGRRI" FT CDS complement(241794..242783) FT /transl_table=11 FT /locus_tag="Rv0493c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0493c, (MTCY20G9.19), len: 329 aa. Conserved FT hypothetical protein, showing some similarity to FT U00018_33|B2168_F2_93 from Mycobacterium leprae (167 aa), FT FASTA scores: opt: 166, E(): 0.00077, (35.9% identity in FT 131 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:Q11158" FT /protein_id="CAB00954.1" FT /translation="MGESTTQPAGGAAVDDETRSAALPRWRGAAGRLEVWYATLSDPLT FT RTGLWVHCETVAPTTGGPYAHGWVTWFPPDAPPGTERFGPQPAQPAAGPAWFDIAGVRM FT APAELTGRTRSLAWELSWKDTAAPLWTFPRVAWERELLPGAQVVIAPTAVFAGSLAVGE FT TTHRVDSWRGSVAHIYGHGNAKRWGWIHADLGDGDVLEVVTAVSHKPGLRRLAPLAFVR FT FRIDGKDWPASPLPSLRMRTTLGVRHWQLEGRIGGREALIRVDQPPERCVSLGYTDPDG FT AKAVCTNTEQADIHIELGGRHWSVLGTGHAEVGLRGTAAPAIKEGTPA" FT CDS 242788..243516 FT /transl_table=11 FT /locus_tag="Rv0494" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0494, (MTCY20G9.20), len: 242 aa. Probable FT transcriptional regulator, GntR family, with C-terminal FT part highly similar to S72893|B2168_C2_205 hypothetical FT protein from Mycobacterium leprae (105 aa). Also similar to FT other transcription regulators e.g. PDHR_ECOLI|P06957 FT pyruvate dehydrogenase complex repressor PDHR or GENA from FT Escherichia coli (254 aa), FASTA scores: opt: 284, E(): FT 1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains FT PS00043 Bacterial regulatory proteins, gntR family FT signature, and probable helix-turn helix motif from aa FT 50-71 (Score 1229, +3.37 SD)." FT /db_xref="GOA:P67739" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67739" FT /protein_id="CAB00955.2" FT /translation="MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPE FT RDLAERLGVNRTSLRQGLARLQQMGLIEVRHGSGSVVRDPEGLTHPAVVEALVRKLGPD FT FLVELLEIRAALGPLIGRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYFRVL FT IHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAAAAAT FT VEAYLNASALRMVKSYRDRA" FT misc_feature 242920..242985 FT /note="PS00043 Bacterial regulatory proteins, gntR family FT signature" FT CDS complement(243517..244407) FT /transl_table=11 FT /locus_tag="Rv0495c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0495c, (MTCY20G9.21c), len: 296 aa. Conserved FT hypothetical protein, highly similar to S72915|B2168_F1_37 FT hypothetical protein from Mycobacterium leprae (323 aa), FT FASTA scores: opt: 1615, E(): 0, (82.7% identity in 271 aa FT overlap); and FT P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925 FT conserved hypothetical protein from Mycobacterium leprae FT (277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16 FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (271 FT aa)." FT /db_xref="UniProtKB/Swiss-Prot:P64713" FT /protein_id="CAB00956.1" FT /translation="MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPGQ FT EVELDFAREWVEFYDPDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCSHG FT AFLSDDDDRTRLADAVHKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGACIF FT LNRPGFAGGAGCALHSKALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILKTTLT FT EYDRRGWGSGGADLHWYCTGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAMCKRRS FT QLGLIAVHPATRAAQ" FT CDS 244487..245473 FT /transl_table=11 FT /locus_tag="Rv0496" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0496, (MTCY20G9.22), len: 328 aa. Conserved FT hypothetical protein, highly similar to FT S72894|467046|AAA17230.1|U00018 exopolyphosphatase (EC FT 3.6.1.11) ppx from Mycobacterium leprae (406 aa), FASTA FT scores: opt: 1902, E(): 0, (86.6% identity in 343 aa FT overlap); and FT P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925 FT HYPOTHETICAL 36.2 KDA PROTEIN from Mycobacterium leprae FT (339 aa). Also highly similar to hypothetical proteins and FT exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa). FT C-terminal region similar to CGU31224_1|Q46054 protein FT similar to ppx gene product of Mycobacterium leprae from FT Cornybacterium glutamicum (140 aa), FASTA scores: opt: 615, FT E(): 2.7e-33, (70.9% identity in 134 aa overlap)." FT /db_xref="GOA:P65786" FT /db_xref="InterPro:IPR003695" FT /db_xref="UniProtKB/Swiss-Prot:P65786" FT /protein_id="CAB00922.1" FT /translation="MVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTID FT EFAKIAISSGCAELMAFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFLAV FT RRWYGWSAGRILNLDIGGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGRRRV FT AMLRDWLDAELAEPSVTVLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRTLTAN FT GLRQLIAFISRMTAVDRAELEGVSADRAPQIVAGALVAEASMRALSIEAVEICPWALRE FT GLILRKLDSEADGTALIESSSVHTSVRAVGGQPADRNAANRSRGSKP" FT CDS 245470..246402 FT /transl_table=11 FT /locus_tag="Rv0497" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0497, (MTCY20G9.23), len: 310 aa. Probable FT conserved transmembrane protein, equivalent (but shorter in FT C-terminus) to P54580|Y497_MYCLE|ML2433 HYPOTHETICAL 37.9 FT KDA PROTEIN from Mycobacterium leprae (355 aa). N-terminus FT highly similar to S72922|B2168_C1_166|467074 hypothetical FT protein from Mycobacterium leprae (118 aa), FASTA scores: FT opt: 350, E(): 1.4e-12, (57.9% identity in 114 aa overlap); FT and hydrophobic C-terminus, highly similar to FT S72895|B2168_C2_209|467047 hypothetical protein from FT Mycobacterium leprae (241 aa), FASTA scores: opt: 473, E(): FT 8e-19, (53.9% identity in 241 aa)." FT /db_xref="GOA:P64715" FT /db_xref="UniProtKB/Swiss-Prot:P64715" FT /protein_id="CAB00923.1" FT /translation="MTGPHPETESSGNRQISVAELLARQGVTGAPARRRRRRRGDSDAI FT TVAELTGEIPIIRDDHHHAGPDAHASQSPAANGRVQVGEAAPQSPAEPVAEQVAEEPTR FT TVYWSQPEPRWPKSPPQDRRESGPELSEYPRPLRHTHSDRAPAGPPSGAEHMSPDPVEH FT YPDLWVDVLDTEVGEAEAETEVREAQPGRGERHAAAAAAGTDVEGDGAAEARVARRALD FT VVPTLWRGALVVLQSILAVAFGAGLFIAFDQLWRWNSIVALVLSVMVILGLVVSVRAVR FT KTEDIASTLIAVAVGALITLGPLALLQSG" FT CDS 246418..247260 FT /transl_table=11 FT /locus_tag="Rv0498" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0498, (MTCY20G9.24), len: 280 aa. Conserved FT hypothetical protein, highly similar to FT P54581|Y498_MYCLE|ML2432 HYPOTHETICAL 30.5 KDA PROTEIN from FT Mycobacterium leprae (280 aa); and S72896|B2168_C2_210 FT hypothetical protein from Mycobacterium leprae (244 aa), FT FASTA scores: opt: 1486, E():0, (89.3% identity in 244 aa FT overlap). Also similar to Q9X8H0|Y714_STRCO|SCE7.14c FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor." FT /db_xref="InterPro:IPR012307" FT /db_xref="UniProtKB/Swiss-Prot:P64717" FT /protein_id="CAB00924.1" FT /translation="MRPAIKVGLSTASVYPLRAEAAFEYADRLGYDGVELMVWGESVSQ FT DIDAVRKLSRRYRVPVLSVHAPCLLISQRVWGANPILKLDRSVRAAEQLGAQTVVVHPP FT FRWQRRYAEGFSDQVAALEAASTVMVAVENMFPFRADRFFGAGQSRERMRKRGGGPGPA FT ISAFAPSYDPLDGNHAHYTLDLSHTATAGTDSLDMARRMGPGLVHLHLCDGSGLPADEH FT LVPGRGTQPTAEVCQMLAGSGFVGHVVLEVSTSSARSANERESMLAESLQFARTHLLR" FT CDS 247276..248151 FT /transl_table=11 FT /locus_tag="Rv0499" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0499, (MTCY20G9.25), len: 291 aa. Conserved FT hypothetical protein, showing some similarity to FT AL031184|SC2A11_16|T34762 hypothetical protein from FT Streptomyces coelicolor (340 aa), FASTA scores: opt: 240, FT E(): 1.8e-07, (28.9% identity in 270 aa overlap)." FT /db_xref="GOA:P64719" FT /db_xref="InterPro:IPR001206" FT /db_xref="UniProtKB/Swiss-Prot:P64719" FT /protein_id="CAB00925.1" FT /translation="MNALFTTAMALRPLDSDPGNPACRVFEGELNEHWTIGPKVHGGAM FT VALCANAARTAYGAAGQQPMRQPVAVSASFLWAPDPGTMRLVTSIRKRGRRISVADVEL FT TQGGRTAVHAVVTLGEPEHFLPGVDGSGGASGTAPLLSANPVVELMAPEPPEGVVPIGP FT GHQLAGLVHLGEGCDVRPVLSTLRSATDGRPPVIQLWARPRGVAPDALFALLCGDLSAP FT VTFAVDRTGWAPTVALTAYLRALPADGWLRVLCTCVEIGQDWFDEDHIVVDRLGRIVVQ FT TRQLAMVPAQ" FT CDS 248176..249063 FT /transl_table=11 FT /gene="proC" FT /locus_tag="Rv0500" FT /product="PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC FT (P5CR) (P5C REDUCTASE)" FT /function="INVOLVED AT THE TERMINAL (THIRD) STEP IN PROLINE FT BIOSYNTHESIS [CATALYTIC ACTIVITY: L-proline + NAD(P)+ = FT 1-pyrroline-5-carboxylate + NAD(P)H]." FT /EC_number="1.5.1.2" FT /note="Rv0500, (MTCY20G9.26), len: 295 aa. Probable proC, FT Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (see FT citation below), equivalent to P46725|PROC_MYCLE FT PYRROLINE-5-CARBOXYLATE REDUCTASE from Mycobacterium leprae FT (294 aa), FASTA scores: opt: 1473, E(): 0, (82.4% identity FT in 295 aa overlap). Also similar to others e.g. FT P46540|PROC_CORGL PYRROLINE-5-CARBOXYLATE REDUCTASE from FT Corynebacterium glutamicum (270 aa); FT T36286|4803683|CAB42663.1|AL049819 pyrroline-5-carboxylate FT reductase from Streptomyces coelicolor (284 aa); etc. FT BELONGS TO THE PYRROLINE-5-CARBOXYLATE REDUCTASE FAMILY." FT /db_xref="GOA:Q11141" FT /db_xref="InterPro:IPR000304" FT /db_xref="UniProtKB/Swiss-Prot:Q11141" FT /protein_id="CAB00926.1" FT /translation="MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRAN FT YLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVV FT AGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGG FT VLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAML FT LERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQ FT AAKSRSEQLRITPE" FT CDS 249204..249440 FT /transl_table=11 FT /locus_tag="Rv0500A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0500A, len: 78 aa. Conserved hypothetical protein, FT similar to proteins from Mycobacterium leprae and FT Streptomyces coelicolor e.g. U00018_25 from Mycobacterium FT leprae cosmid B2168 (86 aa), FASTA scores: opt: 428, E(): FT 1.3e-27, (82.6% identity in 86 aa overlap); FT AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 FT (70 aa), FASTA scores: opt: 252, E(): 1.2 e-13, (72.2 FT identity in 54 aa overlap)." FT /db_xref="GOA:Q8VKK5" FT /db_xref="InterPro:IPR010093" FT /db_xref="UniProtKB/TrEMBL:Q8VKK5" FT /protein_id="CAE55290.1" FT /translation="MTSTNGPSARDTGFVEGQQAKTQLLTVAEVAALMRVSKMTVYRLV FT HNGELPAVRVGRSFRVHAKAVHDMLETSYFDAG" FT CDS 249568..249669 FT /transl_table=11 FT /locus_tag="Rv0500B" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0500B, len: 33 aa. Conserved hypothetical protein. FT Basic protein 18 of the 33 aa are Arg or Lys, with strong FT similarity to AL079345|SCE68_25 protein from Streptomyces FT coelicolor cosmid E6 (32 aa), FASTA scores: opt: 176, E(): FT 1e-06, (93.1% identity in 29 aa overlap). Same gene FT arrangement in both actinomycetes." FT /db_xref="InterPro:IPR013177" FT /db_xref="UniProtKB/Swiss-Prot:P0A5C9" FT /protein_id="CAE55291.1" FT /translation="MGSVIKKRRKRMSKKKHRKLLRRTRVQRRKLGK" FT CDS 249747..250877 FT /transl_table=11 FT /gene="galE2" FT /locus_tag="Rv0501" FT /standard_name="galE1" FT /product="POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 FT (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE FT DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE FT DIPHOSPHO-GALACTOSE 4-EPIMERASE)" FT /function="INVOLVED IN GALACTOSE METABOLISM [CATALYTIC FT ACTIVITY: UDP-GLUCOSE = UDP-GALACTOSE]." FT /EC_number="5.1.3.2" FT /note="Rv0501, (MTCY20G9.28), len: 376 aa. Possible galE2, FT UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar FT (except in N-terminus) to CAC31944.1|AL583925 possible FT glucose epimerase/dehydratase from Mycobacterium leprae FT (364 aa). N-terminus highly similar to FT S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical FT protein from Mycobacterium leprae (180 aa), FASTA scores: FT opt: 934, E(): 0, (89.6% identity in 164 aa overlap); and FT C-terminus highly similar to FT S72898|467050|AAA17234.1|U00018 hypothetical protein from FT Mycobacterium leprae (168 aa), FASTA scores: opt: 928, E(): FT 0, (82.7% identity in 168 aa overlap). Also highly similar FT to T36274|5123671|CAB45360.1|AL079345 probable epimerase FT from Streptomyces coelicolor (353 aa); and similar in part FT to other epimerases e.g. GALE_ECOLI|P09147 UDP-glucose FT 4-epimerase from Escherichia coli (338 aa), FASTA scores: FT opt: 241, E(): 6.7e-09, (28.2% identity in 294 aa overlap); FT etc. BELONGS TO THE SUGAR EPIMERASE FAMILY. COFACTOR: NAD. FT Note that previously known as galE1." FT /db_xref="GOA:P0A5D1" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P0A5D1" FT /protein_id="CAB08987.2" FT /translation="MSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLAQ FT NPLINRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAASYA FT PRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDSSSR FT RPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPLVPTI FT FGRDARLQLLHEQDALGALERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVPVPGFG FT VWALDSLRRANHYTELNREQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRG FT LTPIIDPHRVRSWEGRAVGLAQRWGSRNPIPWSGLR" FT CDS 250884..251960 FT /transl_table=11 FT /locus_tag="Rv0502" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0502, (MTCY20G9.29), len: 358 aa. Conserved FT hypothetical protein, equivalent to FT P54878|Y502_MYCLE|ML2427 HYPOTHETICAL 40.5 KDA PROTEIN from FT Mycobacterium leprae (367 aa), FASTA scores: opt: 2042, FT E(): 0, (84.1% identity in 365 aa overlap). Also similar to FT T36273|SCE68.23c hypothetical protein from Streptomyces FT coelicolor (355 aa). C-terminal similar to FT AL021529|SC10A5_4|T34572 hypothetical protein from FT Streptomyces coelicolor (295 aa), FASTA score: (57.8% FT identity in 263 aa overlap); and to hypothetical proteins FT from Mycobacterium tuberculosis Rv1920|G70808 (287 aa); and FT Rv1428c|G70914 (275 aa)." FT /db_xref="GOA:P64723" FT /db_xref="InterPro:IPR016676" FT /db_xref="UniProtKB/Swiss-Prot:P64723" FT /protein_id="CAB00928.1" FT /translation="MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDPN FT DRASAEQIAAVVREIDEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSVDE FT FGFDPHFNSAIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLMLSV FT AVHDEHPAHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAVFPEG FT YKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLLARLFG FT LPYFPITPLFPLAGPVGLVPLPSKWRIAFGEPICTADYASTDADDPMVTFELTDQVRET FT IQQTLYRLLAGRRNIFFG" FT CDS complement(251964..252872) FT /transl_table=11 FT /gene="cmaA2" FT /locus_tag="Rv0503c" FT /standard_name="cma2" FT /product="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 FT CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) FT (CYCLOPROPANE MYCOLIC ACID SYNTHASE 2) (MYCOLIC ACID FT TRANS-CYCLOPROPANE SYNTHETASE)" FT /function="ESSENTIAL FOR THE CYCLOPROPANATION FUNCTION. FT TRANSFERS A METHYLENE GROUP FROM S-ADENOSYL-L-METHIONINE TO FT THE CIS DOUBLE BOND OF AN UNSATURATED FATTY ACID CHAIN FT RESULTING IN THE REPLACEMENT OF THE DOUBLE BOND WITH A FT METHYLENE BRIDGE. MYCOLIC ACIDS, WHICH REPRESENT THE MAJOR FT CONSTITUENT OF MYCOBACTERIAL CELL WALL COMPLEX, ACT AS FT SUBSTRATES [CATALYTIC ACTIVITY: S-adenosyl-L-methionine + FT phospholipid olefinic fatty acid = FT S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty FT acid]." FT /EC_number="2.1.1.79" FT /note="Rv0503c, (MTCY20G9.30c), len: 302 aa. cmaA2 FT (alternate gene name: cma2), FT cyclopropane-fatty-acyl-phospholipid synthase 2 (mycolic FT acid trans-cyclopropane synthetase) (EC 2.1.1.79) (see FT citations below). Note that this protein has 302 aa and not FT 322 aa: we have chosen a different initiation codon on the FT basis of homology). Equivalent to S72886|B2168_F3_130 FT hypothetical protein from Mycobacterium leprae (308 aa), FT FASTA score: (78.9% identity in 303 aa overlap); and highly FT similar to other proteins from Mycobacterium leprae. Also FT similar to other proteins from Mycobacterium tuberculosis FT and Mycobacterium bovis BCG e.g. FT MTV038_14|UMAA2|Rv0470c|MTV038.14 PUTATIVE MYCOLIC ACID FT SYNTHESIS/MODIFICATION PROTEIN (287 aa) (57.2% identity in FT 297 aa overlap)." FT /db_xref="GOA:P0A5P0" FT /db_xref="InterPro:IPR003333" FT /db_xref="PDB:1KPI" FT /db_xref="UniProtKB/Swiss-Prot:P0A5P0" FT /experiment="experimental evidence, no additional details FT record |