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EBI DbfetchID BX842572; SV 1; linear; genomic DNA; STD; PRO; 341957 BP. XX AC BX842572; AL021427-AL021428; AL021926-AL021930; Z74410; Z80233; Z80775; AC Z86089; Z92669; Z92770; Z96071; Z97050; XX DT 21-NOV-2003 (Rel. 77, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium tuberculosis H37Rv complete genome; segment 1/13 XX KW complete genome. XX OS Mycobacterium tuberculosis H37Rv OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1038/31159 RX PUBMED; 9634230. RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J., RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the complete RT genome sequence"; RL Nature 393(6685):537-544(1998). XX RN [2] RX PUBMED; 12368430. RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.; RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv"; RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002). XX RN [3] RP 1-341957 RA Parkhill J.; RT ; RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: RL parkhill@sanger.ac.uk XX DR EMBL-CON; AL123456. DR RFAM; RF00504; Glycine. XX CC Notes: CC Details of M. tuberculosis sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/) XX FH Key Location/Qualifiers FH FT source 1..341957 FT /organism="Mycobacterium tuberculosis H37Rv" FT /strain="H37Rv" FT /mol_type="genomic DNA" FT /db_xref="taxon:83332" FT CDS 1..1524 FT /transl_table=11 FT /gene="dnaA" FT /locus_tag="Rv0001" FT /product="CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA" FT /function="PLAYS AN IMPORTANT ROLE IN THE INITIATION AND FT REGULATION OF CHROMOSOMAL REPLICATION. BINDS TO THE ORIGIN FT OF REPLICATION; IT BINDS SPECIFICALLY DOUBLE-STRANDED DNA FT AT A 9 BP CONSENSUS (DNAA BOX): 5'-TTATC(C/A)A(C/A)A-3'. FT DNAA BINDS TO ATP AND TO ACIDIC PHOSPHOLIPIDS. DNAA PROTEIN FT BINDS THE ORIGIN OF REPLICATION (oriC), ATP AND ADP, AND FT EXHIBITED WEAK ATPase ACTIVITY." FT /note="Rv0001, (MT0001, MTV029.01, P49993), len: 507 aa. FT dnaA, chromosomal replication initiator protein (see FT citations below), equivalent to other Mycobacterial FT CHROMOSOMAL REPLICATION INITIATOR PROTEINS e.g. FT P46388|DNAA_MYCLE from Mycobacterium leprae (502 aa); FT Q9L7L7|DNAA_MYCPA from Mycobacterium paratuberculosis (509 FT aa); P49990|DNAA_MYCAV from Mycobacterium avium (508 aa); FT P49992|DNAA_MYCSM from Mycobacterium smegmatis (504 aa); FT etc. Also highly similar to others except in N-terminus FT e.g. Q9ZH75|DNAA_STRCH CHROMOSOMAL REPLICATION INITIATOR FT PROTEIN from Streptomyces chrysomallus (624 aa); FT Q9ZH76|DNAA_STRRE from Streptomyces reticuli (643 aa); FT DNAA_ECOLI|P03004|B3702 chromosomal replication initiator FT protein from Escherichia coli strain K12 (467 aa), FASTA FT scores: opt: 986, E(): 0, (43.2% identity in 389 aa FT overlap); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop) and PS01008 DnaA protein signature. BELONGS TO FT THE DNAA FAMILY. Note that the first base of this gene has FT been taken as base 1 of the Mycobacterium tuberculosis FT H37Rv genomic sequence." FT /db_xref="GOA:P49993" FT /db_xref="HSSP:1L8Q" FT /db_xref="InterPro:IPR013317" FT /db_xref="UniProtKB/Swiss-Prot:P49993" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16238.1" FT /translation="MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQR FT AWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAPPA FT TDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPHNTDSATA FT GVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAAG FT NYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEG FT IQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIA FT ILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKALAEIVL FT RDLIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYLCRELTDLS FT LPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR" FT misc_feature 622..645 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 1384..1440 FT /note="PS01008 DnaA protein signature" FT CDS 2052..3260 FT /transl_table=11 FT /gene="dnaN" FT /locus_tag="Rv0002" FT /product="DNA POLYMERASE III (BETA CHAIN) DNAN (DNA FT NUCLEOTIDYLTRANSFERASE)" FT /function="DNA POLYMERASE III IS A COMPLEX, MULTICHAIN FT ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN FT BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' FT EXONUCLEASE ACTIVITY. THE BETA CHAIN IS REQUIRED FOR FT INITIATION OF REPLICATION ONCE IT IS CLAMPED ONTO DNA, IT FT SLIDES FREELY (BIDIRECTIONAL AND ATP-INDEPENDENT) ALONG FT DUPLEX DNA [CATALYTIC ACTIVITY: N deoxynucleoside FT triphosphate = N diphosphate + {DNA}N]." FT /EC_number="2.7.7.7" FT /note="Rv0002, (MTV029.02, MTCY10H4.0), len: 402 aa. dnaN, FT DNA polymerase III (beta chain) (EC 2.7.7.7) (see citations FT below), equivalent to other Mycobacterial DNA POLYMERASES FT III BETA CHAIN e.g. NP_301130.1|NC_002677 from FT Mycobacterium leprae (399 aa); Q9L7L6|DP3B_MYCPA from FT Mycobacterium avium subsp. paratuberculosis (399 aa); FT P52851|DP3B_MYCSM from Mycobacterium smegmatis (397 aa); FT etc. Also highly similar to others e.g. P27903|DP3B_STRCO FT DNA POLYMERASE III BETA CHAIN from Streptomyces coelicolor FT (376 aa), FASTA scores: opt: 1189, E(): 0, (52.8% identity FT in 337 aa overlap); P21174|DP3B_MICLU from Micrococcus FT luteus (310 aa); P52023|DP3B_SYNP7 from Synechococcus sp. FT strain PCC 7942 (375 aa); etc. Overlaps and extends CDS in FT neighbouring cosmid MTCY10H4.01." FT /db_xref="GOA:Q50790" FT /db_xref="HSSP:2POL" FT /db_xref="InterPro:IPR001001" FT /db_xref="UniProtKB/Swiss-Prot:Q50790" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16239.1" FT /translation="MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGV FT LLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEG FT NRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPM FT LTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGS FT DVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELI FT EAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYL FT TDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYVYLLMPVR FT LPG" FT CDS 3280..4437 FT /transl_table=11 FT /gene="recF" FT /locus_tag="Rv0003" FT /product="DNA REPLICATION AND REPAIR PROTEIN RECF FT (SINGLE-STRAND DNA BINDING PROTEIN)" FT /function="THE RECF PROTEIN IS INVOLVED IN DNA METABOLISM FT AND RECOMBINATION; IT IS REQUIRED FOR DNA REPLICATION AND FT NORMAL SOS INDUCIBILITY. RECF BINDS PREFERENTIALLY TO FT SINGLE-STRANDED, LINEAR DNA. IT ALSO SEEMS TO BIND ATP." FT /note="Rv0003, (MTCY10H4.01), len: 385 aa. recF, DNA FT replication and repair protein (see citations below), FT equivalent to others Mycobacterial DNA replication and FT repair proteins e.g. NP_301131.1|NC_002677 from FT Mycobacterium leprae (385 aa); Q9L7L5|RECF_MYCPA from FT Mycobacterium avium subsp. paratuberculosis (385 aa); FT P50916|RECF_MYCSM from Mycobacterium smegmatis (384 aa); FT etc. Also highly similar to others e.g. P36176|RECF_STRCO FT DNA REPLICATION AND REPAIR PROTEIN from Streptomyces FT coelicolor (373 aa); NP_440892.1|NC_000911 from FT Synechocystis sp. strain PCC 6803 (384 aa); FT NP_469352.1|NC_003212 from Listeria innocua (370 aa); etc. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop), FT PS00617 RecF protein signature 1, and PS00618 RecF protein FT signature 2. BELONGS TO THE RECF FAMILY." FT /db_xref="GOA:Q59586" FT /db_xref="InterPro:IPR003395" FT /db_xref="UniProtKB/Swiss-Prot:Q59586" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02424.1" FT /translation="MYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALWY FT STTLGSHRVSADLPLIRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSVRS FT TRDVVGVLRAVLFAPEDLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVLRQRTA FT LLKSVPGARYRGDRGVFDTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQLLAPE FT SRSASIGYRASMDVTGPSEQSDIDRQLLAARLLAALAARRDAELERGVCLVGPHRDDLI FT LRLGDQPAKGFASHGEAWSLAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVMRRRALA FT TAAESAEQVLVTAAVLEDIPAGWDARRVHIDVRADDTGSMSVVLP" FT misc_feature 3367..3390 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 3634..3690 FT /note="PS00617 RecF protein signature 1" FT misc_feature 4243..4296 FT /note="PS00618 RecF protein signature 2" FT CDS 4434..4997 FT /transl_table=11 FT /locus_tag="Rv0004" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0004, (MTCY10H4.02), len: 187 aa. Conserved FT hypothetical protein (see Salazar et al., 1996), highly FT similar, but longer 21 aa in N-terminus, to FT AAF33696.1|AF222789 unknown protein from Mycobacterium FT avium subsp. paratuberculosis (166 aa); and highly similar FT to NP_301132.1|NC_002677 conserved hypothetical protein FT from Mycobacterium leprae (189 aa); S70990 hypothetical FT protein from Mycobacterium smegmatis (194 aa). Also highly FT similar, except in N-terminal part, to FT NP_599256.1|NC_003450 conserved hypothetical protein from FT Corynebacterium glutamicum (178 aa), 47.0% identity. Also FT very weakly similar in C-terminus to C-terminal part of FT P35925|YREG_STRCO HYPOTHETICAL 19.8 KDA PROTEIN (IN FT RECF-GYRB INTERGENIC REGION) from Streptomyces coelicolor FT (190 aa), FASTA scores: opt: 404, E(): 3.9e-18, (40.7% FT identity in 189 aa overlap)." FT /db_xref="InterPro:IPR007922" FT /db_xref="UniProtKB/Swiss-Prot:P71573" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02425.1" FT /translation="MTGSVDRPDQNRGERSMKSPGLDLVRRTLDEARAAARARGQDAGR FT GRVASVASGRVAGRRRSWSGPGPDIRDPQPLGKAARELAKKRGWSVRVAEGMVLGQWSA FT VVGHQIAEHARPTALNDGVLSVIAESTAWATQLRIMQAQLLAKIAAAVGNDVVRSLKIT FT GPAAPSWRKGPRHIAGRGPRDTYG" FT CDS 5123..7267 FT /transl_table=11 FT /gene="gyrB" FT /locus_tag="Rv0005" FT /product="DNA GYRASE (SUBUNIT B) GYRB (DNA TOPOISOMERASE FT (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA FT TOPOISOMERASE)" FT /function="DNA GYRASE NEGATIVELY SUPERCOILS CLOSED CIRCULAR FT DOUBLE-STRANDED DNA IN AN ATP-DEPENDENT MANNER AND ALSO FT CATALYZES THE INTERCONVERSION OF OTHER TOPOLOGICAL ISOMERS FT OF DOUBLE-STRANDED DNA RINGS, INCLUDING CATENANES AND FT KNOTTED RINGS [CATALYTIC ACTIVITY: ATP-dependent breakage, FT passage and rejoining of double-stranded DNA]." FT /EC_number="5.99.1.3" FT /note="Rv0005, (MTCY10H4.03), len: 714 aa. gyrB, DNA gyrase FT subunit B (EC 5.99.1.3) (see citations below), equivalent, FT except in N-terminus, to other Mycobacterial DNA GYRASES FT SUBUNIT B e.g. T10005 from Mycobacterium leprae (697 aa); FT Q9L7L3|GYRB_MYCPA from Mycobacterium avium subsp. FT paratuberculosis (677 aa) (has its N-terminus shorter); FT P48355|GYRB_MYCSM from Mycobacterium smegmatis (675 aa); FT etc. Also highly similar to others e.g. T10969 from FT Streptomyces coelicolor (686 aa); P50075|GYBS_STRSH from FT Streptomyces spheroides (684 aa); etc. Contains PS00177 DNA FT topoisomerase II signature. BELONGS TO THE TYPE II FT TOPOISOMERASE FAMILY." FT /db_xref="GOA:P0C5C5" FT /db_xref="InterPro:IPR006171" FT /db_xref="PDB:2ZJT" FT /db_xref="UniProtKB/Swiss-Prot:P0C5C5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02426.1" FT /translation="MGKNEARRSALAPDHGTVVCDPLRRLNRMHATPEESIRIVAAQKK FT KAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTV FT NVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVG FT VSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETT FT EYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTA FT PHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESV FT HTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV FT KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIA FT ARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAI FT LPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDG FT QHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLK FT AGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGED FT VDARRSFITRNAKDVRFLDV" FT misc_feature 6608..6634 FT /note="PS00177 DNA topoisomerase II signature" FT CDS 7302..9818 FT /transl_table=11 FT /gene="gyrA" FT /locus_tag="Rv0006" FT /product="DNA GYRASE (SUBUNIT A) GYRA (DNA TOPOISOMERASE FT (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA FT TOPOISOMERASE)" FT /function="DNA GYRASE NEGATIVELY SUPERCOILS CLOSED CIRCULAR FT DOUBLE-STRANDED DNA IN AN ATP-DEPENDENT MANNER AND ALSO FT CATALYZES THE INTERCONVERSION OF OTHER TOPOLOGICAL ISOMERS FT OF DOUBLE-STRANDED DNA RINGS, INCLUDING CATENANES AND FT KNOTTED RINGS [CATALYTIC ACTIVITY: ATP-dependent breakage, FT passage and rejoining of double-stranded DNA]." FT /EC_number="5.99.1.3" FT /note="Rv0006, (MTCY10H4.04), len: 838 aa. gyrA, DNA gyrase FT subunit A (EC 5.99.1.3) (see citations below), equivalent, FT except in N-terminus, to other Mycobacterial DNA GYRASES FT SUBUNIT A e.g. Q57532|GYRA_MYCLE|T10006 from Mycobacterium FT leprae (1273 aa); P48354|GYRA_MYCSM from Mycobacterium FT smegmatis (842 aa); etc. Also highly similar to others e.g. FT P35885|GYRA_STRCO DNA GYRASE SUBUNIT A from Streptomyces FT coelicolor (864 aa); NP_346654.1|NC_003030 from Clostridium FT acetobutylicum (830 aa); NP_387888.1|NC_000964 from FT Bacillus subtilis (821 aa); etc. Contains PS00018 EF-hand FT calcium-binding domain." FT /db_xref="GOA:Q07702" FT /db_xref="HSSP:1AB4" FT /db_xref="InterPro:IPR013758" FT /db_xref="UniProtKB/Swiss-Prot:Q07702" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02427.1" FT /translation="MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVR FT DGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWS FT LRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEP FT TVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGR FT VKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHD FT NFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTS FT FGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALD FT ALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKI FT EAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVV FT VTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRV FT YRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKS FT KLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIRFSATDEALRPMG FT RATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTV FT MYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTL FT LAIARNAEESGDDNAVDANGADQTGN" FT misc_feature 8811..8849 FT /note="PS00018 EF-hand calcium-binding domain" FT CDS 9914..10828 FT /transl_table=11 FT /locus_tag="Rv0007" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0007, (MTCY10H4.05), len: 304 aa. Possible FT conserved membrane protein, highly similar to FT Z70722|MLCB1770_7 from Mycobacterium leprae (303 aa), FASTA FT scores: opt: 812, E(): 1.6e-25, (54.2% identity in 319 aa FT overlap). C-terminal part highly similar to C-terminus of FT CAB92992.1|AL357152 putative integral membrane protein from FT Streptomyces coelicolor (185 aa); and N-terminal part FT highly similar to C-terminus of NP_302684.1|NC_002677 FT hypothetical protein from Mycobacterium leprae (123 aa)." FT /db_xref="GOA:P71575" FT /db_xref="UniProtKB/Swiss-Prot:P71575" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02428.1" FT /translation="MTAPNEPGALSKGDGPNADGLVDRGGAHRAATGPGRIPDAGDPPP FT WQRAATRQSQAGHRQPPPVSHPEGRPTNPPAAADARLNRFISGASAPVTGPAAAVRTPQ FT PDPDASLGCGDGSPAEAYASELPDLSGPTPRAPQRNPAPARPAEGGAGSRGDSAAGSSG FT GRSITAESRDARVQLSARRSRGPVRASMQIRRIDPWSTLKVSLLLSVALFFVWMITVAF FT LYLVLGGMGVWAKLNSNVGDLLNNASGSSAELVSSGTIFGGAFLIGLVNIVLMTALATI FT GAFVYNLITDLIGGIEVTLADRD" FT tRNA 10887..10960 FT /gene="tRNA-Ile (GAT)" FT /product="transfer RNA-Ile(GAT)" FT /anticodon=(pos:10921..10923,aa:Ile) FT tRNA 11112..11184 FT /gene="tRNA-Ala(TGC)" FT /product="transfer RNA-Ala (TGC)" FT /anticodon=(pos:11145..11147,aa:Ala) FT CDS complement(11874..12311) FT /transl_table=11 FT /locus_tag="Rv0008c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0008c, (MTCY10H4.07c), len: 145 aa. Possible FT membrane protein." FT /db_xref="GOA:P71577" FT /db_xref="UniProtKB/Swiss-Prot:P71577" FT /protein_id="CAB02429.1" FT /translation="MSEQVETRLTPRERLTRGLAYSAVGPVDVTRGLLELGVGLGLQSA FT RSTAAGLRRRYREGRLAREVAAAQETLAQELTAAQDVVANLPQALQDARTQRRSKHHLW FT IFAGIAAAILAGGAVAFSIVRRSSRPEPSPRPPSVEVQPRS" FT CDS 12468..13016 FT /transl_table=11 FT /gene="ppiA" FT /locus_tag="Rv0009" FT /standard_name="cfp22" FT /product="PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS FT ISOMERASE A PPIA (PPIase A) (ROTAMASE A)" FT /function="PPIASES ACCELERATE THE FOLDING OF PROTEINS FT [CATALYTIC ACTIVITY: CIS-TRANS ISOMERIZATION OF PROLINE FT IMIDIC PEPTIDE BONDS IN OLIGOPEPTIDES]." FT /EC_number="5.2.1.8" FT /note="Rv0009, (MTCY10H4.08), len: 182. Probable ppiA FT (alternate gene name: cfp22), iron-regulated FT peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8), FT equivalent to NP_301138.1|NC_002677 putative FT peptidyl-prolyl cis-trans isomerase from Mycobacterium FT leprae (182 aa), FASTA score: (90.1% identity in 182 aa FT overlap). Also highly similar to others e.g. T36725 from FT Streptomyces coelicolor (177 aa); T43805 from Halobacterium FT salinarum (180 aa); NP_219383.1|NC_000919 from Treponema FT pallidum (215 aa); etc. BELONGS TO THE CYCLOPHILIN-TYPE FT PPIASE FAMILY. Alternative start codon has been suggested." FT /db_xref="GOA:P65762" FT /db_xref="InterPro:IPR002130" FT /db_xref="PDB:1W74" FT /db_xref="UniProtKB/Swiss-Prot:P65762" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02430.1" FT /translation="MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVGL FT AQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFHPE FT LQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAISKTA FT TDGNDRPTDPVVIESITIS" FT CDS complement(13133..13558) FT /transl_table=11 FT /locus_tag="Rv0010c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0010c, (MTCY10H4.10c), len: 141 aa. Probable FT conserved membrane protein, equivalent to FT NP_301139.1|NC_002677 putative membrane protein from FT Mycobacterium leprae (137 aa); and similar to FT Rv1417|P71686|YE17_MYCTU HYPOTHETICAL 16.4 kDa PROTEIN from FT Mycobacterium tuberculosis (154 aa), FASTA scores: opt: FT 121, E(): 0.097, (29.6% identity in 81 aa overlap)." FT /db_xref="GOA:P71580" FT /db_xref="UniProtKB/Swiss-Prot:P71580" FT /protein_id="CAB02431.1" FT /translation="MQQTAWAPRTSGIAGCGAGGVVMAIASVTLVTDTPGRVLTGVAAL FT GLILFASATWRARPRLAITPDGLAIRGWFRTQLLRHSNIKIIRIDEFRRYGRLVRLLEI FT ETVSGGLLILSRWDLGTDPVEVLDALTAAGYAGRGQR" FT CDS complement(13714..13995) FT /transl_table=11 FT /locus_tag="Rv0011c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0011c, (MTCY10H4.11c), len: 93 aa. Probable FT conserved transmembrane protein, equivalent to FT NP_301140.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (93 aa); and similar to FT AL079308|SCH69_24 hypothetical protein from Streptomyces FT coelicolor (84 aa), FASTA scores: opt: 135, E(): 0.0068, FT (32.6% identity in 92 aa overlap)." FT /db_xref="GOA:P67376" FT /db_xref="InterPro:IPR009619" FT /db_xref="UniProtKB/Swiss-Prot:P67376" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02432.1" FT /translation="MPKSKVRKKNDFTVSAVSRTPMKVKVGPSSVWFVSLFIGLMLIGL FT IWLMVFQLAAIGSQAPTALNWMAQLGPWNYAIAFAFMITGLLLTMRWH" FT CDS 14089..14877 FT /transl_table=11 FT /locus_tag="Rv0012" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0012, (MTCY10H4.12), len: 262 aa. Probable FT conserved membrane protein, similar to FT AL079308|SCH69_23|T36722 hypothetical protein from FT Streptomyces coelicolor (237 aa), FASTA scores: opt: 506, FT E(): 1.9e-25, (39.8% identity in 236 aa overlap). Some FT similarity to BLU0|1958_35A2 DIVIB (fragment) (188 aa), FT FASTA scores: opt: 204, E(): 8.9e-07, (35.6% identity in 90 FT aa overlap); and G1129091|DDS cell division and sporulation FT protein from Bacillus subtilis (231 aa), FASTA scores: opt: FT 180, E(): 3.8e-05, (30.7% identity in 101 aa overlap). Also FT similar to Rv1823|MTCY1A11_20 from Mycobacterium FT tuberculosis FASTA score: (30.1% identity in 246 aa FT overlap); and MTCY1A11_18 FASTA score: (25.5% identity in FT 235 aa overlap). Contains probable N-terminal signal FT sequence." FT /db_xref="InterPro:IPR010273" FT /db_xref="UniProtKB/TrEMBL:P71582" FT /protein_id="CAB02446.1" FT /translation="MRLTHPTPCPENGETMIDRRRSAWRFSVPLVCLLAGLLLAATHGV FT SGGTEIRRSDAPRLVDLVRRAQASVNRLATEREALTTRIDSVHGRSVDTALAAMQRRSA FT KLAGVAAMNPVHGPGLVVTLQDAQRDANGRFPRDASPDDLVVHQQDIEAVLNALWNAGA FT EAIQMQDQRIIAMSIARCVGNTLLLNGRTYSPPYTIAAIGDAAAMQAALAAAPLVTLYK FT QYVVRFGLGYCEEVHPDLQIVGYADPVRMHFAQPAGPLDY" FT CDS 14914..15612 FT /transl_table=11 FT /gene="trpG" FT /locus_tag="Rv0013" FT /standard_name="pabA" FT /product="POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG FT (GLUTAMINE AMIDOTRANSFERASE)" FT /function="POSSIBLY INVOLVED IN BIOSYNTHESIS OF TRYPTOPHAN FT (AT THE FIRST STEP). SUPPOSED TETRAMER OF TWO COMPONENTS I FT AND TWO COMPONENTS II: COMPONENT I (Rv1609|trpE) CATALYZES FT THE FORMATION OF ANTHRANILATE USING AMMONIA RATHER THAN FT GLUTAMINE, WHEREAS COMPONENT II (Rv0013|trpG) PROVIDES FT GLUTAMINE AMIDOTRANSFERASE ACTIVITY. POSSIBLY PARTICIPATES FT IN THE TRYPTOPHAN-DEPENDENT INDOLE-3-ACETIC ACID PRODUCTION FT [CATALYTIC ACTIVITY: CHORISMATE + L-GLUTAMINE = FT ANTHRANILATE + PYRUVATE + L-GLUTAMATE]." FT /EC_number="4.1.3.27" FT /note="Rv0013, (MTCY10H4.13), len: 232 aa. Possible trpG, FT anthranilate synthase component II (glutamine FT amidotransferase) (EC 4.1.3.27), equivalent to FT NP_301141.1|NC_002677 putative p-aminobenzoate synthase FT glutamine amidotransferase from Mycobacterium leprae (232 FT aa). Also highly similar to others e.g. P26922|TRPG_AZOBR FT Anthranilate synthase component II from Azospirillum FT brasilense (196 aa), FASTA scores: opt: 703, E(): 8.6e-40, FT (56.7% identity in 187 aa overlap); T36720 probable FT glutamine amidotransferase from Streptomyces coelicolor FT (212 aa); T44524 anthranilate synthase from Nitrosomonas FT europaea (199 aa); etc. Also similar to E235740 FT para-aminobenzoate synthase (232 aa), FASTA scores: opt: FT 1273, E(): 0, (79.7% identity in 232 aa overlap). Contains FT PS00606 Beta-ketoacyl synthases active site; and PS00442 FT Glutamine amidotransferases class-I active site. SIMILARITY FT TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAINS. Note FT that previously known as pabA." FT /db_xref="GOA:Q7DAK6" FT /db_xref="InterPro:IPR017926" FT /db_xref="UniProtKB/TrEMBL:Q7DAK6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55234.1" FT /translation="MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAG FT QFDGVLLSPGPGTPERAGASVSIVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPELL FT HGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQHTG FT LPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTAS FT AGEATGRTSA" FT misc_feature 15100..15150 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 15145..15180 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT CDS complement(15590..17470) FT /transl_table=11 FT /gene="pknB" FT /locus_tag="Rv0014c" FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE B FT PKNB (PROTEIN KINASE B) (STPK B)" FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO REGULATE CELL FT DIVISION/DIFFERENTIATION. CAN PHOSPHORYLATE THE PEPTIDE FT SUBSTRATE MYELIN BASIC PROTEIN (MBP) [CATALYTIC ACTIVITY: FT ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]." FT /EC_number="2.7.1.-" FT /note="Rv0014c, (MTCY10H4.14c), len: 626 aa. pknB, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-) FT (see citations below), equivalent to MLCB1770_9|T10009 FT probable serine/threonine-specific protein kinase from FT Mycobacterium leprae (622 aa), FASTA scores: opt: 3600, FT E(): 0, (86.4% identity in 626 aa overlap). Also similar FT (highly similar in N-terminus) to others e.g. T36717 from FT Streptomyces coelicolor (673 aa); NP_389459.1|NC_000964 FT from Bacillus subtilis (648 aa); NP_465345.1|NC_003210 from FT Listeria monocytogenes (655 aa); E235741 protein kinase FT pknB (315 aa), FASTA scores: opt: 1839, E(): 0, (90.8 FT identity in 305 aa overlap); etc. Contains PS00107 Protein FT kinases ATP-binding region signature, and PS00108 FT Serine/Threonine protein kinases active-site signature. FT Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FT FAMILY OF PROTEIN KINASES. Experimental studies show FT evidence of auto-phosphorylation on serine/threonine FT residues." FT /db_xref="GOA:P0A5S4" FT /db_xref="InterPro:IPR002290" FT /db_xref="PDB:1MRU" FT /db_xref="UniProtKB/Swiss-Prot:P0A5S4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02434.1" FT /translation="MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRAD FT LARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIV FT HTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAI FT ADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPV FT SVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEP FT PEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLA FT VLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHV FT IGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSP FT STPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGF FT TKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEP FT RLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ" FT misc_feature complement(17033..17071) FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT misc_feature complement(17351..17422) FT /note="PS00107 Protein kinases ATP-binding region FT signature" FT CDS complement(17467..18762) FT /transl_table=11 FT /gene="pknA" FT /locus_tag="Rv0015c" FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE A FT PKNA (PROTEIN KINASE A) (STPK A)" FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT PHOSPHORYLATION). THOUGHT TO REGULATE MORPHOLOGICAL CHANGES FT ASSOCIATED WITH CELL DIVISION/DIFFERENTIATION PROCESS. FT PHOSPHORYLATES AT SERINE AND THREONINE RESIDUES [CATALYTIC FT ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]." FT /EC_number="2.7.1.-" FT /note="Rv0015c, (MTCY10H4.15c), len: 431 aa. pknA, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-), FT magnesium/manganese dependent (see citations below), FT equivalent to MLCB1770_10|NP_301143.1|NC_002677 putative FT serine/threonine protein kinase from Mycobacterium leprae FT (437 aa), FASTA scores: opt: 1883, E(): 0, (72.1% identity FT in 434 aa overlap). And also highly similar to other FT kinases from Mycobacterium leprae e.g. MLCB1770_10 from FT Mycobacterium leprae (437 aa). Also similar to PKNA_MYCLE FT protein kinase (253 aa), FASTA scores: opt: 1525, E(): 0, FT (95.0% identity in 242 aa overlap); etc. Also highly FT similar in part to others e.g. N-terminus of FT NP_243370.1|NC_002570 from Bacillus halodurans (664 aa); FT N-terminus of T36717 from Streptomyces coelicolor (673 aa); FT etc. Also similar to others from Mycobacterium FT tuberculosis: MTCY10H4_15, MTV021_9, MTCY28_5, MTCY4C12_28, FT MTCY50_16, MTCY8D9_8, MTCY49_28, MTCY4C12_30, MTCY28_9, FT etc. Contains PS00108 Serine/Threonine protein kinases FT active-site signature. Contains Hank's kinase subdomain. FT BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. It has FT been shown that sodium orthovanadate inhibits the activity FT of the enzyme in vitro." FT /db_xref="GOA:P65726" FT /db_xref="HSSP:1O6Y" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:P65726" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02435.1" FT /translation="MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLK FT SEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLN FT SVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIA FT KAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGA FT LTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPP FT RPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSRPATGGHRPPRRTFSSGQRAL FT LWAAGVLGALAIIIAVLLVIKAPGDNSPQQAPTPTVTTTGNPPASNTGGTDASPRLNWT FT ERGETRHSGLQSWVVPPTPHSRASLARYEIAQ" FT misc_feature complement(18316..18354) FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT CDS complement(18759..20234) FT /transl_table=11 FT /gene="pbpA" FT /locus_tag="Rv0016c" FT /product="PROBABLE PENICILLIN-BINDING PROTEIN PBPA" FT /function="INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THE FT FINAL STAGES). CELL WALL FORMATION; PBPA IS SUPPOSED TO BE FT RESPONSIBLE FOR THE DETERMINATION OF THE ROD SHAPE OF THE FT CELL. ITS SYNTHESIZES CROSS-LINKED PEPTIDOGLYCAN FROM LIPID FT INTERMEDIATES." FT /note="Rv0016c, (MTCY10H4.16c), len: 491 aa. Probable pbpA, FT penicillin-binding protein, equivalent to FT NP_301144.1|NC_002677 putative penicillin-binding protein FT from Mycobacterium leprae (492 aa); and highly similar to FT MLCB1770_1 penicillin binding protein from Mycobacterium FT leprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4% FT identity in 472 aa overlap). Also similar to others e.g. FT T36716 from Streptomyces coelicolor (490 aa); FT AAF61246.1|AF241575|PbpA from Streptomyces griseus (485 FT aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum FT (482 aa); E235825|pbpA penicillin binding protein (325 aa), FT FASTA scores: opt: 1618, E(): 0, (78.3% identity in 323 aa FT overlap); etc. And also similar to MTCY270_5 and MTV003_8 FT from Mycobacterium tuberculosis." FT /db_xref="GOA:P71586" FT /db_xref="InterPro:IPR001460" FT /db_xref="UniProtKB/Swiss-Prot:P71586" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02436.1" FT /translation="MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVLL FT DEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALERAE FT DPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKGAVV FT ALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGS FT TFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKS FT CNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQK FT DVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVSPQVAAKL FT TELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPKVAVAV FT LVENGADRLSATGGALAAPIGRAVIEAALQGEP" FT CDS complement(20231..21640) FT /transl_table=11 FT /gene="rodA" FT /locus_tag="Rv0017c" FT /standard_name="ftsW" FT /product="PROBABLE CELL DIVISION PROTEIN RODA" FT /function="THIS IS A SEPTUM-PEPTIDOGLYCAN BIOSYNTHETIC FT PROTEIN, INVOLVED IN CELL WALL FORMATION. PLAYS A ROLE IN FT THE STABILIZATION OF THE FTSZ RING DURING CELL DIVISION." FT /note="Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA FT (alternate gene name: ftsW), cell division protein, FT integral membrane protein, equivalent to MLCB1770_12|T10012 FT probable cell division protein from Mycobacterium leprae FT (465 aa), FASTA scores: opt: 2475, E(): 0, (81.9% identity FT in 469 aa overlap). Also highly similar to others e.g. FT T36715|SCH69.16 from Streptomyces coelicolor (479 aa); FT NP_243432.1|NC_002570 from Bacillus halodurans (366 aa); FT NP_347145.1|NC_003030 from Clostridium acetobutylicum (400 FT aa); etc. Also similar to MTCY270_14 from Mycobacterium FT tuberculosis FASTA score: (32.2% identity in 369 aa FT overlap). BELONGS TO THE FTSW/RODA/SPOVE FAMILY." FT /db_xref="GOA:P63760" FT /db_xref="InterPro:IPR018365" FT /db_xref="UniProtKB/Swiss-Prot:P63760" FT /protein_id="CAB02437.1" FT /translation="MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQD FT QGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLVDN FT EIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPALLP FT AALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGMTLPR FT PRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTLFAAGT FT LVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQPDTVPAA FT STDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLSSTLAIQL FT FIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRTRPRNKSPI FT TAAGTEVIERV" FT CDS complement(21637..23181) FT /transl_table=11 FT /gene="ppp" FT /locus_tag="Rv0018c" FT /product="POSSIBLE SERINE/THREONINE PHOSPHATASE PPP" FT /function="INVOLVED IN REGULATION (USING DEPHOSPHORYLATION FT OF A SPECIFIC PHOSPHORYLATED SUBSTRATE)." FT /EC_number="3.1.3.16" FT /note="Rv0018c, (MTCY10H4.18c), len: 514 aa. Possible ppp, FT serine/threonine phosphatase (EC 3.1.3.16), equivalent to FT MLCB1770_13|T10013 PUTATIVE PHOSPHOPROTEIN PHOSPHATASE from FT Mycobacterium leprae (509 aa), FASTA scores: opt: 2517, FT E(): 0. Also highly similar to others e.g. T36714 probable FT protein phosphatase from Streptomyces coelicolor (515 aa); FT CAA10712.1|AJ132604 pppL protein from Lactococcus lactis FT (258 aa); NP_248765.1|NC_002516 probable phosphoprotein FT phosphatase from Pseudomonas aeruginosa (242 aa); etc. Also FT similar to BSUB0009_46 YLOO PROTEIN from Bacillus subtilis FT (254 aa), FASTA score: (34.0% identity in 250 aa overlap)." FT /db_xref="GOA:P71588" FT /db_xref="InterPro:IPR014045" FT /db_xref="PDB:1TXO" FT /db_xref="UniProtKB/Swiss-Prot:P71588" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02438.1" FT /translation="MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAA FT GEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAI FT LFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIM FT RALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELA FT LRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIV FT KRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMR FT GIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAG FT LPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSP FT TTSAPAPTGTTPAIPTSASPAAPASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA" FT repeat_region complement(23173..23273) FT /note="101 bp Mycobacterial Interspersed Repetitive Unit, FT Class I. See Supply et al. (1997) Molecular Microbiology FT 26, 991-1003" FT CDS complement(23270..23737) FT /transl_table=11 FT /locus_tag="Rv0019c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0019c, (MTCY10H4.19c), len: 155 aa. Conserved FT hypothetical protein, equivalent to FT MLCB1770_14|NP_301147.1|NC_002677 conserved hypothetical FT protein from Mycobacterium leprae (155 aa), FASTA scores: FT opt: 902, E(): 0, (91.0% identity in 155 aa overlap). Also FT highly similar to T36713|AL079308|SCH69_14 from FT Streptomyces coelicolor (172 aa), FASTA scores: opt: 389, FT E(): 6e-21, (46.2% identity in 171 aa overlap); and similar FT in C-terminus to others e.g. NP_342559.1|NC_002754 FT Conserved hypothetical protein from Sulfolobus solfataricus FT (209 aa); etc. C-terminus also highly similar to C-terminal FT part of AAF07901.1|AF173844_2|AF173844 putative signal FT transduction protein GarA from Mycobacterium smegmatis (158 FT aa). Also similar to Rv1827|MTCY 1A11.16c from FT Mycobacterium tuberculosis ( 162 aa), FASTA score: (41.2% FT identity in 85 aa overlap); MTMOAIS_3; MAU66560_1 and FT MLCB1788_15." FT /db_xref="HSSP:1MZK" FT /db_xref="InterPro:IPR000253" FT /db_xref="UniProtKB/TrEMBL:P71589" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02439.1" FT /translation="MQGLVLQLTRAGFLMLLWVFIWSVLRILKTDIYAPTGAVMMRRGL FT ALRGTLLGARQRRHAARYLVVTEGALTGARITLSEQPVLIGRADDSTLVLTDDYASTRH FT ARLSMRGSEWYVEDLGSTNGTYLDRAKVTTAVRVPIGTPVRIGKTAIELRP" FT CDS complement(23861..25444) FT /transl_table=11 FT /gene="TB39.8" FT /locus_tag="Rv0020c" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB39.8" FT /function="UNKNOWN" FT /note="Rv0020c, (MTCY10H4.20c), len: 527 aa. TB39.8, FT conserved hypothetical protein, identified by proteomic FT study by the Statens Serum Institute, Denmark (spot TB39.8) FT (see citation below). Highly similar to FT NP_301148.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (488 aa); and FT Z70722|MLCB1770_15|T10015 hypothetical protein from FT Mycobacterium leprae (463 aa), FASTA scores: opt: 1213, FT E(): 2.2e-32, (72.3% identity in 506 aa overlap). FT Alternative start codon in position 24979 has been FT suggested (see citation below)." FT /db_xref="HSSP:1MZK" FT /db_xref="InterPro:IPR000253" FT /db_xref="UniProtKB/TrEMBL:P71590" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02440.1" FT /translation="MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAA FT DGIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGWQTYGDV FT VVRFEQSSNLHTGQFRARGTVNPDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNSSYR FT GGQGQGRPDEYYDDRYARPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRPRHPD FT QGDYPEQIGYPDQGGYPEQRGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYEQRPPV FT SPGPAAGYGAPGYDQGYRQSGGYGPSPGGGQPGYGGYGEYGRGPARHEEGSYVPSGPPG FT PPEQRPAYPDQGGYDQGYQQGATTYGRQDYGGGADYTRYTESPRVPGYAPQGGGYAEPA FT GRDYDYGQSGAPDYGQPAPGGYSGYGQGGYGSAGTSVTLQLDDGSGRTYQLREGSNIIG FT RGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRL FT GHSEIIVRMH" FT tRNA 25644..25726 FT /gene="tRNA-Leu(CAG)" FT /product="transfer RNA-Leu(CAG)" FT /anticodon=(pos:25677..25679,aa:Leu) FT CDS complement(25913..26881) FT /transl_table=11 FT /locus_tag="Rv0021c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0021c, (MTCY10H4.21c), len: 322 aa. Conserved FT hypothetical protein, similar to various proteins e.g. FT NP_464341.1|NC_003210 protein similar to oxidoreductases FT from Listeria monocytogenes (309 aa); NP_357973.1|NC_003098 FT Enoyl-acyl carrier protein(ACP) reductase from FT Streptococcus pneumoniae (324 aa); 2NPD_NEUCR|G726338 FT 2-nitropropane dioxygenase precursor from Neurospora crassa FT (378 aa), FASTA scores: opt: 383, E(): 1.1e-16, (32.2% FT identity in 348 aa overlap); etc. Also similar to FT AE001747_25 from Thermotoga maritima section 59 (314 aa), FT FASTA scores: opt: 442, E(): 1.5e-19, (30.5% identity in FT 325 aa overlap). Also similar to other proteins from FT Mycobacterium tuberculosis e.g. Rv3553 (355 aa), FASTA FT scores: E(): 6.8e-15, (35.3 identity in 235 aa overlap); FT and Rv1533 (375 aa), FASTA scores: E(): 4.7e-12, (34.4% FT identity in 262 aa overlap)." FT /db_xref="GOA:P71591" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:P71591" FT /protein_id="CAB02441.1" FT /translation="MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGG FT GYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFAD FT AIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVT FT ARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLAATGD FT DMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAVAARDY FT SIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV" FT CDS complement(27023..27442) FT /transl_table=11 FT /gene="whiB5" FT /locus_tag="Rv0022c" FT /standard_name="whmG" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT WHIB-LIKE WHIB5" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0022c, (MTCY10H4.22c), len: 139 aa. Probable whiB5 FT (alternate gene name: whmG), WhiB-like regulatory protein FT (see citations below), similar to WhiB paralogue of FT Streptomyces coelicolor, wblE gene product (85 aa). Shows FT some similarity to FT O88103|AJ239086|SCO239086_1|WHID|SC6G4.45c|WBLB WHID FT PROTEIN from Streptomyces coelicolor (112 aa), FASTA FT scores: opt: 125, E(): 0.055, (37.1% identity in 97 aa FT overlap); and slight similarity to G466960|WHIB WHIB FT PROTEIN (102 aa), FASTA scores: opt: 112, E(): 0.14, (34.3 FT identity in 67 aa overlap)." FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:P71592" FT /protein_id="CAB02442.1" FT /translation="MAHPCATDPELWFGYPDDDGSDGAAKARAYERSATQARIQCLRRC FT PLLQQRRCAQHAVEHRVEYGVWAGIKLPGGQYRKREQLAAAHDVLRRIAGGEINSRQLP FT DNAALLARNEGLEVTPVPGVVVHLPIAQVGPQPAA" FT CDS 27595..28365 FT /transl_table=11 FT /locus_tag="Rv0023" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0023, (MTCY10H4.23),len: 256 aa. Possible FT transcriptional regulator, equivalent to FT CAB96432.1|AJ251434 hypothetical protein from Mycobacterium FT avium subsp. paratuberculosis (146 aa). N-terminus showing FT similarity with other transcriptional regulators e.g. FT AE0002|ECAE000240_9 from Escherichia coli strain K12 (178 FT aa), FASTA scores: opt: 149, E(): 0.0048, (33.3% identity FT in 84 aa overlap); etc. Contains probable helix-turn helix FT motif from aa 19 to 40 (Score 1615, +4.69 SD)." FT /db_xref="GOA:P67704" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/Swiss-Prot:P67704" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02443.1" FT /translation="MSRESAGAAIRALRESRDWSLADLAAATGVSTMGLSYLERGARKP FT HKSTVQKVENGLGLPPGTYSRLLVAADPDAELARLIAAQPSNPTAVRRAGAVVVDRHSD FT TDVLEGYAEAQLDAIKSVIDRLPATTSNEYETYILSVIAQCVKAEMLAASSWRVAVNAG FT ADSTGRLMEHLRALEATRGALLERMPTSLSARFDRACAQSSLPEAVVAALIGVGADEMW FT DIRNRGVIPAGALPRVRAFVDAIEASHDADEGQQ" FT CDS 28362..29207 FT /transl_table=11 FT /locus_tag="Rv0024" FT /product="PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN" FT /function="UNKNOWN. THE P60 PROTEIN IS A MAJOR FT EXTRACELLULAR PROTEIN MAY BE INVOLVED IN THE INVASION OF FT HOST CELLS." FT /note="Rv0024, (MTCY10H4.24), len: 281 aa. Putative FT secreted protein, p60 homologue, similar in part to others FT and relatives proteins e.g. P60_LISIV|Q01837 protein p60 FT precursor (invasion-associated protein) from Listeria FT ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, FT (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 FT putative NPL/P60 family secreted protein from Streptomyces FT coelicolor (347 aa) ; etc. Similar to Mycobacterium FT tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And FT several homologues in Streptomyces coelicolor e.g. FT AL049497|SC6G10_8|T35517 probable secreted protein (338 FT aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity FT in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / FT LISTERIA P60 FAMILY." FT /db_xref="InterPro:IPR000064" FT /db_xref="UniProtKB/TrEMBL:P71594" FT /protein_id="CAB02444.1" FT /translation="MNYSEVELLSRAHQLFAGDSRRPGLDAGTTPYGDLLSRAADLNVG FT AGQRRYQLAVDHSRAALLSAARTDAAAGAVITGAQRDRAWARRSTGTVLDEARSDTTVT FT AVMPIAQREAIRRRVARLRAQRAHVLTARRRARRHLAALRALRYRVAHGPGVALAKLRL FT PSPSGRAGIAVHAALSRLGRPYVWGATGPNQFDCSGLVQWAYAQAGVHLDRTTYQQINE FT GIPVPRSQVRPGDLVFPHPGHVQLAIGNNLVVEAPHAGASVRVSSLGNNVQIRRPLSGR FT " FT CDS 29245..29607 FT /transl_table=11 FT /locus_tag="Rv0025" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0025, (MTCY10H4.25), len: 120 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 FT aa), FASTA score: (37.6% identity in 101 aa overlap), and FT Rv0026 FASTA score: (35.4% identity in 113 aa overlap); FT etc." FT /db_xref="InterPro:IPR019710" FT /db_xref="UniProtKB/Swiss-Prot:P71595" FT /protein_id="CAB02445.1" FT /translation="MSEQAGSSVAVIQERQALLARQHDAVAEADRELADVLASAHAAMR FT ESVRRLDAIAAELDRAVPDQDQLAVDTPMGAREFQTFLVAKQREIVAVVAAAHELDRAK FT SAVLKRLRAQYTEPAR" FT CDS 29722..31068 FT /transl_table=11 FT /locus_tag="Rv0026" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0026, (MTCY10H4.26), len: 448 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins from Mycobacterium tuberculosis: Rv0025 FASTA FT score: (35.4% identity in 113 aa overlap) and Rv0739 (268 FT aa), FASTA score: (32.4% identity in 142 aa overlap)." FT /db_xref="InterPro:IPR019710" FT /db_xref="UniProtKB/Swiss-Prot:P71596" FT /protein_id="CAB02411.1" FT /translation="MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVTS FT TTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDLQV FT VSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIREVV FT ATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPELPTRA FT EPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGATPALVP FT GVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDREGADED FT AGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQGIAIPLPG FT TAVANPVDPARISAGDVGVFTATPLPLALAKLFWTARFNTSQPCEGQTF" FT CDS 31189..31506 FT /transl_table=11 FT /locus_tag="Rv0027" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0027, (MTCY10H4.27), len: 105 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64667" FT /protein_id="CAB02412.1" FT /translation="MTDRIHVQPAHLRQAAAHHQQTADYLRTVPSSHDAIRESLDSLGP FT IFSELRDTGRELLELRKQCYQQQADNHADIAQNLRTSAAMWEQHERAASRSLGNIIDGS FT R" FT CDS 31514..31819 FT /transl_table=11 FT /locus_tag="Rv0028" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0028, (MTCY10H4.28), len: 101 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64669" FT /protein_id="CAB02413.1" FT /translation="MTDANPAFDTVHPSGHILVRSCRGGYMHSVSLSEAAMETDAETLA FT EAILLTADVSCLKALLEVRNEIVAAGHTPSAQVPTTDDLNVAIEKLLAHQLRRRNR" FT CDS 32057..33154 FT /transl_table=11 FT /locus_tag="Rv0029" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0029, (MTCY10H4.29), len: 365 aa. Conserved FT hypothetical protein, showing some similarity to other FT proteins from Mycobacterium tuberculosis e.g. C-terminal FT region of Rv2082|MTCY49_21|E247006 hypothetical 73.6 kDa FT protein (721 aa), FASTA scores: opt: 453, E(): 1.2e-22, FT (38.5% identity in 265 aa overlap); Rv3899c|MTY15F10_12 FT HYPOTHETICAL 40.8 kDa PROTEIN (410 aa), FASTA score: (33.7% FT identity in 252 aa overlap); etc." FT /db_xref="UniProtKB/TrEMBL:P71599" FT /protein_id="CAB02414.1" FT /translation="MAIFGRWSARQRLRRATRESLTIPTFSSSLDCTTRVIGGLWPAEL FT SSNTAETATLAEHLKADLHRIVGSANDELMVIWRAGMADSTRRAEEDRVIDRARASAMR FT RVESAMRELRQITGRVPVEIPRMRGAGGSDLDTTRLMPAVTVVQPADQACTDWPVAAAE FT DDEARLQRLLAFVARQEPRLNWAVGVHADGTTVLVTDVAHGWIPPGIALPEGVRLLAPA FT RRAGRAPELVGITTCCKTYTPGDSLRRAVDSTAPTSSVQPRALPAIAGLSVELGIATQR FT HDGLPKIVHAMATAAGNGAAAEEVDLLRVHVDTALHHVLAQYPRVDPALLLNCMLLAAT FT ERSVTGDPIAANYHFAWFRELDSRR" FT CDS 33224..33553 FT /transl_table=11 FT /locus_tag="Rv0030" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0030, (MTCY10H4.30), len: 109 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64671" FT /protein_id="CAB02415.1" FT /translation="MVSGSDSRSEPSQLSDRDLVESVLRDLSEAADKWEALVTQAETVT FT YSVDLGDVRAVANSDGRLLELTLHPGVMTGYAHGELADRVNLAITALRDEVEAENRARY FT GGRLQ" FT CDS 33582..33794 FT /transl_table=11 FT /locus_tag="Rv0031" FT /product="POSSIBLE REMNANT OF A TRANSPOSASE" FT /function="NORMALY, REQUIRED FOR THE TRANSPOSITION OF AN FT INSERTION ELEMENT." FT /note="Rv0031, (MTCY10H4.31), len: 70 aa. Possible remnant FT of a transposase, showing partial similarity to FT mycobacterial transposases in a short overlap, e.g. FT Rv2791c|MTV002_57 (459 aa), FASTA score: (72.2% identity in FT 36 aa overlap); Rv2885c, Rv2978c, Rv3827c, etc." FT /db_xref="UniProtKB/TrEMBL:P71601" FT /protein_id="CAB02416.1" FT /translation="MLARHFGAGRKAHSRAVATLKADIQAWHPAGIQTPKPRCESDVFA FT RIGHTSHPSTRKSRVGPGASEAPLA" FT CDS 34295..36610 FT /transl_table=11 FT /gene="bioF2" FT /locus_tag="Rv0032" FT /product="POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 FT (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) FT (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP FT SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE)" FT /function="COULD BE INVOLVED IN BIOTIN BIOSYNTHESIS (AT THE FT FIRST STEP) [CATALYTIC ACTIVITY: 6-CARBOXYHEXANOYL-COA + FT L-ALANINE = 8-AMINO-7-OXONONANOATE + CoA + CO2]." FT /EC_number="2.3.1.47" FT /note="Rv0032, (MTCY10H4.32), len: 771 aa. Probable bioF2, FT 8-amino-7-oxononanoate synthase (EC 2.3.1.47), with its FT C-terminal similar to others e.g. BIOF_BACSU|P53556 FT 8-amino-7-oxononanoate synthase from Bacillus subtilis (389 FT aa), FASTA scores: opt: 775, E(): 0, (37.9% identity in 346 FT aa overlap); P22806|BIOF_BACSH from Bacillus sphaericus FT (389 aa); etc. Also similar to BIOF1|Rv1569|MTCY336_35 from FT Mycobacterium tuberculosis (386 aa), AF041819_4 from FT Mycobacterium bovis, and BIOF_MYCLE|P45487 from FT Mycobacterium leprae (385 aa). Contains PS00599 FT Aminotransferases class-II pyridoxal-phosphate attachment FT site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES." FT /db_xref="GOA:P71602" FT /db_xref="HSSP:1BS0" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/TrEMBL:P71602" FT /protein_id="CAB02417.1" FT /translation="MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVC FT FDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPVLA FT GQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVEEAL FT GCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQREDLNP FT EFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYRKANLY FT RAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARM FT MMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFY FT PRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNG FT TLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDALNHRSLFDAA FT RLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLATIAELADRHGC FT RVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIR FT HNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQAEYHG FT TAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTSYLADHRQSDLDRA FT LHVFAGLAEDLTPQGAAL" FT misc_feature 36128..36157 FT /note="PS00599 Aminotransferases class-II FT pyridoxal-phosphate attachment site" FT CDS 36607..36870 FT /transl_table=11 FT /gene="acpA" FT /locus_tag="Rv0033" FT /standard_name="acpP" FT /product="PROBABLE ACYL CARRIER PROTEIN ACPA (ACP)" FT /function="KEY COMPONENT IN DE NOVO FATTY ACID FT BIOSYNTHESIS. THIS PROTEIN IS SUPPOSED TO BE THE CARRIER OF FT THE GROWING FATTY ACID CHAIN IN FATTY ACID BIOSYNTHESIS." FT /note="Rv0033, (MTCY10H4.33), len: 87 aa. Probable acpA FT (alternate gene name: acpP), acyl carrier protein, similar FT to others e.g. ACP_BACSU|P80643 acyl carrier protein (acp) FT from Bacillus subtilis (77 aa), FASTA scores: opt: 149, FT E(): 0.00026, (41.4% identity in 70 aa overlap); FT NP_224500.1|NC_000922 Acyl Carrier Protein from FT Chlamydophila pneumoniae (79 aa); NP_228471.1|NC_000853 FT acyl carrier protein from Thermotoga maritima (81 aa); etc. FT Also similar to proteins of Mycobacterium tuberculosis FT Rv1344 and Rv2244 (31.5% identity in 73 aa overlap)." FT /db_xref="GOA:P71603" FT /db_xref="InterPro:IPR009081" FT /db_xref="PDB:2CGQ" FT /db_xref="UniProtKB/TrEMBL:P71603" FT /protein_id="CAB02418.1" FT /translation="MKEAINATIQRILRTDRGITANQVLVDDLGFDSLKLFQLITELED FT EFDIAISFRDAQNIKTVGDVYTSVAVWFPETAKPAPLGKGTA" FT CDS 36867..37262 FT /transl_table=11 FT /locus_tag="Rv0034" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0034, (MTCY10H4.34), len: 131 aa. Conserved FT hypothetical protein, showing weak similarity to FT AE001980|AE001980_7 hypothetical protein from Deinococcus FT radiodurans (120 aa), FASTA scores: opt: 141, E(): 0.0028, FT (29.3% identity in 123 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64673" FT /protein_id="CAB02419.1" FT /translation="MTDDADLDLVRRTFAAFARGDLAELTQCFAPDVEQFVPGKHALAG FT VFRGVDNVVACLGDTAAAADGTMTVTLEDVLSNTDGQVIAVYRLRASRAGKVLDQREAI FT LVTVAGGRITRLSEFYADPAATESFWA" FT CDS 37259..38947 FT /transl_table=11 FT /gene="fadD34" FT /locus_tag="Rv0035" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD34 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv0035, (MTCY10H4.35), len: 562 aa. Probable fadD34, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT e.g. MBU75685_1 acyl-CoA synthase from Mycobacterium bovis FT (582 aa), FASTA scores: opt: 408, E(): 8.2e-20; etc. Also FT similar to G1171128 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa), FT FASTA scores: opt: 445, E(): 1.3e-21, (28.1% identity in FT 573 aa overlap). Also similar to other proteins from FT Mycobacterium tuberculosis e.g. MTCY02B10.09, FASTA score: FT (32.3% identity in 468 aa overlap), MTCY349_40, MTCY4D9_17, FT MTCY338_18, MTV045_3, MTCY409_4, MTCI237_30, MTCY24G1_8, FT MASC_MYCLE MASC PROTEIN, U00010_6, MTV005_21, MTCY19G5_7, FT MTCY9F9_39, etc." FT /db_xref="GOA:Q7DAJ8" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7DAJ8" FT /protein_id="CAE55235.1" FT /translation="MTAALLSPAIAWQQISACTDRTLTITCEDSEVISYQDLIARAAAC FT IPPLRRLDLKRGEPVLITAHTNLEFLSCFLGLMLHGAVPVPIPPREALKTTERFMTRLG FT PLLRHHRVLICTPAEHDEIRAAASTDCQISRFTALAEAGDEQFGRATAQQLADTATADW FT PLCTLDDDAYVQYTSGSTAAPRGVVITYRNLLSNMRAMAVGSQFQHGDVMGSWLPLHHD FT MGLVGSLFAALFNSVSAVFTTPHRFLYDPLGFLRLLTSSGATHTFMPNFALEWLINAYH FT RRGADIEGIDLHKMRRLIIASEPVHAEGMRRFAATFAGVGLAPTALGSGYGLAEATVAV FT SMSAPNTGFRTETHAAAEVVTGGRVLPGYEVRIDAAPGARAGTIKLRGDSVAAKAYVGG FT KKLDALDEEGFCDTHDLGFLVDDEIVILGRQDEVFIVHGENRFPYDIEFIIRGESEQHR FT TKVACFGVNERVVVVLESPLDSIIDKAEADRLRCQVVAATGLQLDELITVRRGAIPTTT FT SGKLKRRAVAQAYRDGTLPRLATHAWTADPDSAPKTTRSSLEGAH" FT CDS complement(39056..39829) FT /transl_table=11 FT /locus_tag="Rv0036c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0036c, (MTCY10H4.36c), len: 257 aa. Conserved FT hypothetical protein, highly similar to CAB95889.1|AL359988 FT conserved hypothetical protein from Streptomyces (276 aa). FT Also some similarity to Rv3099c|MTCY164_10 (283 aa), FASTA FT scores: E(): 3.3e-05, (25.9% identity in 205 aa overlap)." FT /db_xref="InterPro:IPR013917" FT /db_xref="UniProtKB/Swiss-Prot:P64675" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02421.1" FT /translation="MADPGPFVADLRAESDDLDALVAHLPADRWADPTPAPGWTIAHQI FT GHLLWTDRVALTAVTDEAGFAELMTAAAANPAGFVDDAATELAAVSPAELLTDWRVTRG FT RLHEELLAVPDGRKLAWFGPPMSAASMATARLMETWAHGLDVADALGVIRPATQRLRSI FT AHLGVRTRDYAFIVNNLTPPAEPFLVELRGPSGDTWSWGPSDAAQRVTGSAEDFCFLVT FT QRRALSTLDVNAVGEDAQRWLTIAQAFAGPPGRGR" FT CDS complement(39877..41202) FT /transl_table=11 FT /locus_tag="Rv0037c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF FT MACROLIDE ACROSS THE MEMBRANE." FT /note="Rv0037c, (MTCY10H4.37c), len: 441 aa. Probable FT conserved integral membrane protein, member of major FT facilitator superfamily (MFS) possibly involved in FT transport of macrolide, showing some similarity to FT Rv1258c|MTCY50_24 (419 aa), FASTA score: (25.2% identity in FT 408 aa overlap); and to AL049826|SCH24_20 from Streptomyces FT coelicolor (425 aa), FASTA scores: opt: 725, E(): 0, (36.1% FT identity in 418 aa overlap). Also similarity with several FT MACROLIDE-EFFLUX PROTEINS e.g. from S. pyogenes (405 aa), FT FASTA scores: E(): 1.3e-06, (22.8% identity in 416 aa FT overlap)." FT /db_xref="GOA:P0A5C1" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/Swiss-Prot:P0A5C1" FT /protein_id="CAB02422.1" FT /translation="MPRVEVGLVIHSRMHARAPVDVWRSVRSLPDFWRLLQVRVASQFG FT DGLFQAGLAGALLFNPDRAADPMAIAGAFAVLFLPYSLLGPFAGALMDRWDRRWVLVGA FT NTGRLALIAGVGTILAVGAGDVPLLVGALVANGLARFVASGLSAALPHVVPREQVVTMN FT SVAIASGAVSAFLGANFMLLPRWLLGSGDEGASAIVFLVAIPVSIALLWSLRFGPRVLG FT PDDTERAIHGSAVYAVVTGWLHGARTVVQLPTVAAGLSGLAAHRMVVGINSLLILLLVR FT HVTARAVGGLGTALLFFAATGLGAFLANVLTPTAIRRWGRYATANGALAAAATIQVAAA FT GLLVPVMVVCGFLLGVAGQVVKLCADSAMQMDVDDALRGHVFAVQDALFWVSYILSITV FT AAALIPEHGHAPVFVLFGSAIYLAGLVVHTIVGRRGQPVIGR" FT CDS 41304..41912 FT /transl_table=11 FT /locus_tag="Rv0038" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0038, (MTCY10H4.38), len: 202 aa. Conserved FT hypothetical protein, equivalent to FT MLCB1770_16|Q50191|Y038_MYCLE hypothetical 22.0 kDa from FT Mycobacterium leprae (202 aa), FASTA scores: opt: 1194, FT E(): 0, (88.6% identity in 202 aa overlap). Also highly FT similar or similar to other hypothetical proteins e.g. FT CAB72194.1|AL138851|SCE59.07c from Streptomyces coelicolor FT (193 aa); AAC06288.1|AF050466 from Mycobacterium bovis (82 FT aa) (similarity in N-terminus); NP_224347.1|NC_000922|YqgE FT from Chlamydophila pneumoniae (188 aa); YQGE_ECOLI FT HYPOTHETICAL 20.7 kDa PROTEIN (187 aa), FASTA score: (29.5% FT identity in 166 aa overlap); etc." FT /db_xref="InterPro:IPR003774" FT /db_xref="UniProtKB/Swiss-Prot:P67757" FT /protein_id="CAB02423.1" FT /translation="MVAPHEDPEDHVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIVE FT HNDGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKTMFIGGPVKRDAALCLAVLRVGADP FT EGVPGLRHVAGRLVMVDLDADPEVLAAAVEGVRIYAGYSGWTIGQLEGEIERDDWIVLS FT ALPSDVLVGPRADLWGQVLRRQPLPLSLLATHPIDLSRN" FT CDS complement(42004..42351) FT /transl_table=11 FT /locus_tag="Rv0039c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0039c, (MTCY21D4.02c, MTCY10H4.39c), len: 115 aa. FT Possible conserved transmembrane protein, highly similar to FT NP_301154.1|NC_002677|Z70722|MLCB1770_18 hypothetical FT protein from Mycobacterium leprae (113 aa), FASTA scores: FT opt: 492, E(): 7.8e-27, (64.9% identity in 114 aa FT overlap)." FT /db_xref="GOA:P71696" FT /db_xref="UniProtKB/Swiss-Prot:P71696" FT /protein_id="CAB02447.1" FT /translation="MFLAGVLCMCAAAASALFGSWSLCHTPTADPTALALRAMAPTQLA FT AAVMLAAGGVVAVAAPGHTALMVVIVCIAGAVGTLAAGSWQSAQYALRRETASPTANCV FT GSCAVCTQACH" FT CDS complement(42433..43365) FT /transl_table=11 FT /gene="mtc28" FT /locus_tag="Rv0040c" FT /product="SECRETED PROLINE RICH PROTEIN MTC28 (PROLINE RICH FT 28 KDA ANTIGEN)" FT /function="UNKNOWN" FT /note="Rv0040c, (MTCY21D4.03c), len: 310 aa. mtc28, FT secreted proline rich 28 kDa antigen protein (has FT hydrophobic stretch at N-terminus) (see citation below). FT Highly similar to O33075|PR28_MYCLE|MT10019 Proline rich 28 FT kDa antigen from Mycobacterium leprae (278 aa), FASTA FT scores: opt: 1007, E(): 0, (65.0% identity in 257 aa FT overlap); and Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 FT putative lipoprotein from Mycobacterium leprae (218 aa). FT C-terminal part very similar to lipoprotein Rv1016c from FT Mycobacterium tuberculosis." FT /db_xref="InterPro:IPR019674" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Q6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02536.2" FT /translation="MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPV FT SAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISG FT TLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYT FT SNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYREND FT MTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPA FT PAPGSAPVGLPGQAPGYPPAGTLTPVPPR" FT CDS 43562..46471 FT /transl_table=11 FT /gene="leuS" FT /locus_tag="Rv0041" FT /product="PROBABLE LEUCYL-tRNA SYNTHETASE LEUS FT (LEUCINE--tRNA LIGASE) (LEURS)" FT /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC FT ACTIVITY: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + FT L-leucyl-tRNA(Leu)]." FT /EC_number="6.1.1.4" FT /note="Rv0041, (MTCY21D4.04), len: 969 aa. Probable FT leucyl-tRNA synthetase (EC 6.1.1.4), equivalent to FT NP_301156.1|NC_002677|MLCB628_3 leucyl-tRNA synthase from FT Mycobacterium leprae (972 aa), FASTA score: (83.6% identity FT in 972 aa overlap); and highly similar to MLCB1770_20 from FT Mycobacterium leprae (824 aa), FASTA score: (82.8% identity FT in 824 aa overlap). Also highly similar to others e.g. FT CAB66249.1|AL136518 leucyl-tRNA synthetase from FT Streptomyces coelicolor (966 aa); NP_244147.1|NC_002570 FT leucyl-tRNA synthetase from Bacillus halodurans (806 aa); FT SYL_BACSU|P36430 leucyl-tRNA synthetase from Bacillus FT subtilis (804 aa), FASTA scores: opt: 714, E(): 3.1e-38, FT (43.7% identity in 938 aa overlap); etc. Contains PS00178 FT Aminoacyl-transfer RNA synthetases class-I signature. FT BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:P67510" FT /db_xref="InterPro:IPR013155" FT /db_xref="UniProtKB/Swiss-Prot:P67510" FT /protein_id="CAB02520.1" FT /translation="MTESPTAGPGGVPRADDADSDVPRYRYTAELAARLERTWQENWAR FT LGTFNVPNPVGSLAPPDGAAVPDDKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARYFR FT MVGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGFGHDSRRSFS FT TTDVDFYRWTQWIFLQIYNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKLTAGE FT RADVIDEYRLVYRADSLVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRIT FT AYADRLLDDLDVLDWPEQVKTMQRNWIGRSTGAVALFSARAASDDGFEVDIEVFTTRPD FT TLFGATYLVLAPEHDLVDELVAASWPAGVNPLWTYGGGTPGEAIAAYRRAIAAKSDLER FT QESREKTGVFLGSYAINPANGEPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARAFG FT LPIVEVIAGGNISESAYTGDGILVNSDYLNGMSVPAAKRAIVDRLESAGRGRARIEFKL FT RDWLFARQRYWGEPFPIVYDSDGRPHALDEAALPVELPDVPDYSPVLFDPDDADSEPSP FT PLAKATEWVHVDLDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNSERFCAKENEAY FT WMGPRPAEHGPDDPGGVDLYVGGAEHAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQ FT GYIQAYAYTDARGSYVPAEQVIERGDRFVYPGPDGEVEVFQEFGKIGKSLKNSVSPDEI FT CDAYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVVDEHTGETRVADGVE FT LDIDTLRALHRTIVGVSEDFAALRNNTATAKLIEYTNHLTKKHRDAVPRAAVEPLVQML FT APLAPHIAEELWLRLGNTTSLAHGPFPKADAAYLVDETVEYPVQVNGKVRGRVVVAADT FT DEETLKAAVLTDEKVQAFLAGATPRKVIVVAGRLVNLVI" FT misc_feature 43799..43831 FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT CDS complement(46581..47207) FT /transl_table=11 FT /locus_tag="Rv0042c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY MARR-FAMILY)" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0042c, (MTCY21D4.05c), len: 208 aa. Possible FT transcriptional regulatory protein, MarR-family, highly FT similar except in N-terminus to CAC32228.1|AL583926 FT putative MarR-family regulatory protein from Mycobacterium FT leprae (243 aa). Also similar in part to others e.g. FT AB76343.1|AL158061 putative MarR-family transcriptional FT regulator from Streptomyces coelicolor (163 aa); FT NP_384406.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR FT PROTEIN from Sinorhizobium meliloti (164 aa); FT NP_531782.1|NC_003304 transcriptional regulator, MarR FT family from Agrobacterium tumefaciens (151 aa); etc. Also FT some similarity to Mycobacterium tuberculosis proteins FT Rv2327, Rv0880, and Rv1404." FT /db_xref="GOA:P71699" FT /db_xref="InterPro:IPR000835" FT /db_xref="UniProtKB/TrEMBL:P71699" FT /protein_id="CAB02521.1" FT /translation="MSVVRSIGKKMQRISGPNALAVKGRPTQVYGHTHVRLDCRFMADS FT EFTAPEVTQLAEGLHRALSKLISMLRRGDPNGAAAGDLTLAQLSILVTLLDQGPIRMTD FT LAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRAVLVDITPQGRAVHGESLANRRAA FT LAALLSQLPRSDLETLRKALAPLERLASGEPASGPASNSPARKRA" FT CDS complement(47366..48100) FT /transl_table=11 FT /locus_tag="Rv0043c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0043c, (MTCY21D4.06c), len: 244 aa. Probable FT transcriptional regulator, GntR family, similar to others FT e.g. NP_420584.1|NC_002696 transcriptional regulator GntR FT family from Caulobacter crescentus (221 aa); FT NP_294539.1|NC_001263 transcriptional regulator GntR family FT from Deinococcus radiodurans (267 aa); YIN1_STRAM|P32425 FT hypothetical transcriptional regulatory protein from FT Streptomyces ambofaciens (236 aa), FASTA scores: opt: 170, FT E(): 9.8e-05, (27.6% identity in 127 aa overlap); etc. FT Similar also to SC9B10_7 from Streptomyces coelicolor FASTA FT score: E():0.00038; and Rv0165c|MTCI28_5 from Mycobacterium FT tuberculosis (264 aa), FASTA score: (27.7% identity in 130 FT aa overlap)." FT /db_xref="GOA:P67737" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67737" FT /protein_id="CAB02522.1" FT /translation="MPKKYGVKEKDQVVAHILNLLLTGKLRSGDRVDRNEIAHGLGVSR FT VPIQEALVQLEHDGIVSTRYHRGAFIERFDVATILEHHELDGLLNGIASARAAANPTPR FT ILGQLDAVMRSLRNSKESRAFAECVWEYRRTVNDEYAGPRLHATIRASQNLIPRVFWMT FT YQNSRDDVLPFYEEENAAIHRREPEAARAACIGRSELMAQTMLAELFRRRVLVPPEGAC FT PGPFGAPIPGFARSYQPSSPVP" FT CDS complement(48233..49027) FT /transl_table=11 FT /locus_tag="Rv0044c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0044c, (MTCY21D4.07c), len: 264 aa. Possible FT oxidoreductase (EC 1.-.-.-), highly similar to FT AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase FT from Streptomyces lavendulae (264 aa). Also similar to FT Mycobacterium tuberculosis proteins e.g. Rv1855c, Rv0953c, FT Rv0791c, Rv0132c, etc." FT /db_xref="GOA:P71701" FT /db_xref="InterPro:IPR011251" FT /db_xref="UniProtKB/TrEMBL:P71701" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02523.1" FT /translation="MTSLVRPDLPVRIGVQLQPQHAPHYRAVRDAVRRCEDIGVDIAFT FT WDHFFPLYGDPDGPHFECWTVLGAWAEQTSHIEIGALVTCNSYRNPELLADMARTVDHI FT SGGRLILGIGSGWKQKDYDEYGYRFGTAGSRLDDLAAALPRIKARLGKLNPPPTRDIPV FT LIGGGGERKTLRLVAEYADIWHSFTAGDSYLAKSAVLSTHCSTVGRNPATIERSAAVDG FT GGLIASAEALAGLGVTLLTVGCDGPDYDLSAAAALCRWRDGR" FT CDS complement(49043..49939) FT /transl_table=11 FT /locus_tag="Rv0045c" FT /product="POSSIBLE HYDROLASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN LIPID FT BIOSYNTHESIS." FT /EC_number="3.-.-.-" FT /note="Rv0045c, (MTCY21D4.08c), len 298 aa. Possible FT hydrolase (EC 3.-.-.-), showing similarity with others eg FT NP_107230.1|NC_002678 putative hydrolase from Mesorhizobium FT loti (278 aa); CAB56730.1|AL121600 putative hydrolase from FT Streptomyces coelicolor (302 aa); NP_438361.1|NC_000907 FT putative esterase/lipase from Haemophilus influenzae Rd FT (287 aa); etc. Also similar to Mycobacterium tuberculosis FT proteins Rv3473c, Rv1123c, Rv1938, Rv3617, Rv3670, etc." FT /db_xref="GOA:P71702" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:P71702" FT /protein_id="CAB02524.1" FT /translation="MLSDDELTGLDEFALLAENAEQAGVNGPLPEVERVQAGAISALRW FT GGSAPRVIFLHGGGQNAHTWDTVIVGLGEPALAVDLPGHGHSAWREDGNYSPQLNSETL FT APVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLVDVTPSALQRHAELTAEQR FT GTVALMHGEREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNWVWRYDAIRT FT FGDFAGLWDDVDALSAPITLVRGGSSGFVTDQDTAELHRRATHFRGVHIVEKSGHSVQS FT DQPRALIEIVRGVLDTR" FT CDS complement(50021..51124) FT /transl_table=11 FT /gene="ino1" FT /locus_tag="Rv0046c" FT /standard_name="tbINO" FT /product="MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol FT 1-phosphate synthetase) (D-glucose 6-phosphate FT cycloaldolase) (Glucose 6-phosphate cyclase) FT (Glucocycloaldolase)" FT /function="INVOLVED IN PHOSPHATIDYLINOSITOL (PI) FT BIOSYNTHETIC PATHWAY [CATALYTIC ACTIVITY: D-GLUCOSE FT 6-PHOSPHATE = 1L-MYO-INOSITOL 1-PHOSPHATE]." FT /EC_number="5.5.1.4" FT /note="Rv0046c, (MTCY21D4.09c), len: 367 aa. ino1 FT (alternate gene name: tbINO), myo-inositol-1-phosphate FT synthase (EC 5.5.1.4) (see citations below), equivalent to FT Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113 FT HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae FT (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity FT in 366 aa overlap). N-terminus similar to N-terminus of FT myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803 FT myo-inositol-1-phosphate synthase (510 aa), FASTA scores: FT opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap); FT CAC21218.1|AJ401007 myo-inositol 1P synthase from FT Thermotoga sp. SG1 (335 aa); etc. Also highly similar to FT other hypothetical proteins e.g. AL049826|SCH24_21c FT hypothetical protein from Streptomyces coelicolor (360 aa), FT FASTA scores: opt: 1790, E(): 0, (77.8% identity in 360 aa FT overlap); AE000881_1 conserved protein from M. FT thermoautotrophicus (368 aa); etc." FT /db_xref="GOA:P71703" FT /db_xref="InterPro:IPR016040" FT /db_xref="PDB:1GR0" FT /db_xref="UniProtKB/Swiss-Prot:P71703" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02525.1" FT /translation="MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTST FT VPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQ FT RGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAID FT AGVAFVNALPVFIASDPVWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDRGVQL FT DRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLD FT DRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPA FT SAYLMKSPPEQLPDDIARAQLEEFIIG" FT CDS complement(51185..51727) FT /transl_table=11 FT /locus_tag="Rv0047c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0047c, (MTCY21D4.10c), len: 180 aa. Conserved FT hypothetical protein, equivalent to NP_302717.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (180 aa). Also showing strong similarity to other FT hypothetical proteins e.g. AL049826|SCH24_22|T36587 from FT Streptomyces coelicolor (225 aa), FASTA scores: opt: 583, FT E(): 9e-31, (51.4% identity in 177 aa overlap); etc. Some FT similarity to Rv1176c from Mycobacterium tuberculosis and FT to P94443|YFIO from Bacillus subtilis (182 aa), FASTA FT scores: E(): 0.00066, (24.9% identity in 177 aa overlap). FT Also some similarity to G1163121 MITHRAMYCIN RESISTANCE FT DETERMINANT, ATP-BINDING PROTEIN (219 aa), FASTA scores: FT opt: 143, E(): 0.0091, (29.4% identity in 180 aa overlap)." FT /db_xref="InterPro:IPR005149" FT /db_xref="UniProtKB/TrEMBL:P71704" FT /protein_id="CAB02526.1" FT /translation="MLELAILGLLIESPMHGYELRKRLTGLLGAFRAFSYGSLYPALRR FT MQADGLIAENAAPAGTPVRRARRVYQLTDKGRRRFGELVADTGPHNYTDDGFGVHLAFF FT NRTPAEARMRILEGRRRQVEERREGLREAVARASSSFDRYTRQLHQLGLESSEREVKWL FT NELIAAERAAPNPAEQT" FT CDS complement(51828..52697) FT /transl_table=11 FT /locus_tag="Rv0048c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0048c, MTCY21D4.11c, len: 289 aa. Possible FT membrane protein." FT /db_xref="GOA:P71705" FT /db_xref="InterPro:IPR012551" FT /db_xref="UniProtKB/Swiss-Prot:P71705" FT /protein_id="CAB02527.1" FT /translation="MAKWLGAPLARGVSTATRAKDSDRQDACRILDDALRDGELSMEEH FT RERVSAATKAVTLGDLQRLVADLQVESAPAQMPALKSRAKRTELGLLAAAFVASVLLGV FT GIGWGVYGNTRSPLDFTSDPGAKPDGIAPVVLTPPRQLHSLGGLTGLLEQTRKRFGDTM FT GYRLVIYPEYASLDRVDPADDRRVLAYTYRGGWGDATSSAKSIADVSVVDLSKFDAKTA FT VGIMRGAPETLGLKQSDVKSMYLIVEPVKDPTTPAALSLSLYVSSDYGGGYLVFAGDGT FT IKHVSYPS" FT CDS 52831..53244 FT /transl_table=11 FT /locus_tag="Rv0049" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0049, (MTCY21D4.12), len: 137 aa. Conserved FT hypothetical protein, only equivalent to FT AL022118|MLCB1913_20 hypothetical protein from FT Mycobacterium leprae (138 aa), FASTA scores: opt: 768, E(): FT 0, (83.9% identity in 137 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64677" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02528.1" FT /translation="MDYTLRRRSLLAEVYSGRTGVSEVCDANPYLLRAAKFHGKPSRVI FT CPICRKEQLTLVSWVFGEHLGAVSGSARTAEELILLATRFSEFAVHVVEVCRTCSWNHL FT VKSYVLGAARPARPPRGSGGTRTARNGARTASE" FT CDS 53663..55699 FT /transl_table=11 FT /gene="ponA1" FT /locus_tag="Rv0050" FT /product="PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN FT 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): FT PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN FT TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE FT (DD-TRANSPEPTIDASE)" FT /function="INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THE FT FINAL STAGES), CELL WALL FORMATION. SYNTHESIS OF FT CROSS-LINKED PEPTIDOGLYCAN FROM THE LIPID INTERMEDIATES. FT THE ENZYME HAS A PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE FT N-TERMINAL DOMAIN (FORMATION OF LINEAR GLYCAN STRANDS) AND FT A PENICILLIN-SENSITIVE TRANSPEPTIDASE C-TERMINAL DOMAIN FT (CROSS-LINKING OF THE PEPTIDE SUBUNITS)." FT /EC_number="2.4.2.-" FT /EC_number="3.4.-.-" FT /note="Rv0050, (MTCY21D4.13), len: 678 aa. Probable ponA1, FT penicillin-binding protein (class A), bienzymatic protein FT with transglycosylase (EC 2.4.2.-) and transpeptidase (EC FT 3.4.-.-) activities (see Graham & Clark-Curtiss 1999), FT highly similar to many e.g. NP_302715.1|NC_002677 FT penicillin-binding protein from Mycobacterium leprae (708 FT aa); AAB53123.1|L39923 penicillin binding protein from FT Mycobacterium leprae (686 aa), FASTA scores: (82.3% FT identity in 679 aa overlap); FT Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523 FT penicillin-binding protein 1 from Mycobacterium smegmatis FT (715 aa) (see Billman-Jacobe et al., 1999); FT CAB88838.1|AL353832 probable penicillin-binding protein FT from Streptomyces coelicolor (756 aa); etc. Also similar to FT ponA2|Rv3682|MTV025.030 BIFUNCTIONAL MEMBRANE-ASSOCIATED FT PENICILLIN-BINDING PROTEIN 1A/1B from Mycobacterium FT tuberculosis (810 aa). BELONGS TO THE TRANSGLYCOSYLASE FT FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FT FAMILY IN THE C-TERMINAL SECTION." FT /db_xref="GOA:P71707" FT /db_xref="InterPro:IPR001460" FT /db_xref="UniProtKB/TrEMBL:P71707" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55236.1" FT /translation="MVILLPMVTFTMAYLIVDVPKPGDIRTNQVSTILASDGSEIAKIV FT PPEGNRVDVNLSQVPMHVRQAVIAAEDRNFYSNPGFSFTGFARAVKNNLFGGDLQGGST FT ITQQYVKNALVGSAQHGWSGLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRGAYG FT ISAASKAYFDKPVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMVETKA FT LSPNDRAAQVFPETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQTLNTQGLVV FT TTTIDPQAQRAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVRAYYGGDNANGFDFAQAG FT LQTGSSFKVFALVAALEQGIGLGYQVDSSPLTVDGIKITNVEGEGCGTCNIAEALKMSL FT NTSYYRLMLKLNGGPQAVADAAHQAGIASSFPGVAHTLSEDGKGGPPNNGIVLGQYQTR FT VIDMASAYATLAASGIYHPPHFVQKVVSANGQVLFDASTADNTGDQRIPKAVADNVTAA FT MEPIAGYSRGHNLAGGRDSAAKTGTTQFGDTTANKDAWMVGYTPSLSTAVWVGTVKGDE FT PLVTASGAAIYGSGLPSDIWKATMDGALKGTSNETFPKPTEVGGYAGVPPPPPPPEVPP FT SETVIQPTVEIAPGITIPIGPPTTITLAPPPPAPPAATPTPPP" FT CDS 55696..57378 FT /transl_table=11 FT /locus_tag="Rv0051" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0051, (MTCY21D4.14), len:560 aa. Probable FT conserved transmembrane protein, equivalent to FT NP_302714.1|NC_002677 conserved membrane protein from FT Mycobacterium leprae (564 aa); and highly similar to FT C-terminus of AAF25828.1|AF187306_1|AF187306 putative FT transmembrane protein from Mycobacterium smegmatis (692 FT aa). Also highly similar to MSGDNAB_5|G886306|L222-ORF5 FT (418 aa), FASTA scores: opt: 2163, E(): 0, (78.4% identity FT in 412 aa overlap). Also similar to FT AL049826|SCH24_24|T36589 probable transmembrane protein FT from Streptomyces coelicolor (502 aa), FASTA scores: opt: FT 492, E(): 1.4e-23, (35.8% identity in 522 aa overlap)." FT /db_xref="GOA:P71708" FT /db_xref="InterPro:IPR016570" FT /db_xref="UniProtKB/TrEMBL:P71708" FT /protein_id="CAB02537.1" FT /translation="MTGALSQSSNISPLPLAADLRSADNRDCPSRTDVLGAALANVVGG FT PVGRHALIGRTRLMTPLRVMFAIALVFLALGWSTKAACLQSTGTGPGDQRVANWDNQRA FT YYQLCYSDTVPLYGAELLSQGKFPYKSSWIETDSNGTPQLRYDGQIAVRYMEYPVLTGI FT YQYLSMAIAKTYTALSKVAPLPVVAEVVMFFNVAAFGLALAWLTTVWATSGLAGRRIWD FT AALVAASPLVIFQIFTNFDALATGLATSGLLAWARRRPVLAGVLIGLGSAAKLYPLLFL FT YPLLLLGIRAGRLNALARTMAAAAATWLLVNLPVMLLFPRGWSEFFRLNTRRGDDMDSL FT YNVVKSFTGWRGFDPTLGFWEPPLVLNTVVTLLFVLCCAAIAYIALTAPHRPRVAQLTF FT LTVASFLLVNKVWSPQFSLWLVPLAVLALPHRRILLAWMTIDALVWVPRMYYLYGNPSR FT SLPEQWFTTTVLLRDIAVMVLCGLVVWQIYRPGRDLVRTGGPGALPACGGVDDPVGGVF FT ANAADAPPGRLPSWLRPRLGDEHARERTPDAGRDRTFSGQHRA" FT CDS 57410..57973 FT /transl_table=11 FT /locus_tag="Rv0052" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0052, (MTCY21D4.15), len: 187 aa. Conserved FT hypothetical protein, similar to others e.g. FT AL049587|SC5F2A_30S|T35272 hypothetical protein from FT Streptomyces coelicolor (211 aa), FASTA scores: opt: 531, FT E(): 3.4e-29, (49.5% identity in 182 aa overlap); FT NP_420588.1|NC_002696 ThiJ/PfpI family protein from FT Caulobacter crescentus (267 aa); etc. Some similarity to FT Escherichia coli G1100872|thiJ (198 aa), FASTA scores: opt: FT 178, E(): 6.1e-06, (29.9% identity in 137 aa overlap). Also FT similar to Rv1930c from Mycobacterium tuberculosis (174 FT aa). May be a membrane protein." FT /db_xref="InterPro:IPR002818" FT /db_xref="UniProtKB/TrEMBL:P71709" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02530.1" FT /translation="MPSFDVVFVGHRRGEVRSDNAMLGLLCDAAFDELTRPDVVIFPGG FT IGTRTLIHDQTVLDWVREAHRHTLLTTSVCTGGLVLAAAGLLNGLTATTHWRVQDLFNS FT LGARYVPQRVVEHLPERVITAAGVSSGIDMGLRLVELLVSREAAEASQLMIEYDPQPPV FT DAGSLAKASPATHRLALEFYQHRL" FT CDS 58192..58482 FT /transl_table=11 FT /gene="rpsF" FT /locus_tag="Rv0053" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S6 RPSF" FT /function="BINDS TOGETHER WITH S18 TO 16S RIBOSOMAL RNA." FT /note="Rv0053, (MTCY21D4.16), len: 96 aa. Probable 30S FT ribosomal protein S6, equivalent to RS6_MYCLE|P46389 30s FT ribosomal protein s6 from Mycobacterium leprae (96 aa), FT FASTA scores: opt: 570, E(): 1.1e-36, (91.7% identity in 96 FT aa overlap).Also highly similar to many e.g. FT Q9X8U2|RS6_STRCO 30S RIBOSOMAL PROTEIN S6 from Streptomyces FT coelicolor (96 aa); etc. Contains PS01048 Ribosomal protein FT S6 signature. BELONGS TO THE S6P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P66591" FT /db_xref="HSSP:1CQM" FT /db_xref="InterPro:IPR014717" FT /db_xref="UniProtKB/Swiss-Prot:P66591" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02531.1" FT /translation="MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGKVEKVDIWGK FT RRLAYEIAKHAEGIYVVIDVKAAPATVSELDRQLSLNESVLRTKVMRTDKH" FT misc_feature 58318..58347 FT /note="PS01048 Ribosomal protein S6 signature" FT CDS 58586..59080 FT /transl_table=11 FT /gene="ssb" FT /locus_tag="Rv0054" FT /product="PROBABLE SINGLE-STRAND BINDING PROTEIN SSB FT (HELIX-DESTABILIZING PROTEIN)" FT /function="THIS PROTEIN IS ESSENTIAL FOR REPLICATION OF THE FT CHROMOSOME. IT IS ALSO INVOLVED IN DNA RECOMBINATION AND FT REPAIR." FT /note="Rv0054, (MTCY21D4.17), len: 164 aa. Probable ssb, FT single-strand binding protein (see Mizrahi & Andersen FT 1998), equivalent to highly similar to others e.g. FT SSB_MYCLE|P46390 single-strand binding protein from FT Mycobacterium leprae (140 aa), FASTA scores: opt: 792, E(): FT 0, (92.6% identity in 135 aa overlap); and FT AAK30583.1|AF349434 single-stranded DNA-binding protein FT from Mycobacterium smegmatis (165 aa). Also highly similar FT to others e.g. T36594 probable single-strand binding FT protein from Streptomyces coelicolor (199 aa); etc. Also FT similar to Rv2478c|MTV008_34c CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (161 aa), FASTA FT score: E (): 1.1e-06. BELONGS TO THE SSB FAMILY." FT /db_xref="GOA:P0A610" FT /db_xref="InterPro:IPR011344" FT /db_xref="PDB:1UE1" FT /db_xref="UniProtKB/Swiss-Prot:P0A610" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02532.1" FT /translation="MAGDTTITIVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQTG FT EWKDGEALFLRCNIWREAAENVAESLTRGARVIVSGRLKQRSFETREGEKRTVIEVEVD FT EIGPSLRYATAKVNKASRSGGFGSGSRPAPAQTSSASGDDPWGSAPASGSFGGGDDEPP FT F" FT CDS 59122..59376 FT /transl_table=11 FT /gene="rpsR1" FT /locus_tag="Rv0055" FT /standard_name="rpsR" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S18-1 RPSR1" FT /function="THIS PROTEIN HAS BEEN IMPLICATED IN FT AMINOACYL-TRANSFER RNA BINDING. IT APPEARS TO BE SITUATED FT AT THE DECODING SITE OF MESSENGER RNA." FT /note="Rv0055, (MTCY21D4.18), len: 84 aa. Probable rpsR1, FT 30S ribosomal protein S18-1, equivalent to FT NP_302711.1|NC_002677|O53125|RS18_MYCLE 30S RIBOSOMAL FT PROTEIN from Mycobacterium leprae (84 aa). Also highly FT similar to others e.g. Q9X8U4|R18A_STRCO 30S RIBOSOMAL FT PROTEIN S18-1 from Streptomyces coelicolor (78 aa); FT RS18_B|ACST|P10806 30s ribosomal protein s18 (bs21) (77 FT aa), FASTA scores: opt: 220, E(): 4e-10, (52.2% identity in FT 67 aa overlap); etc. Also similar to MTCY63A_5 from FT Mycobacterium tuberculosis. BELONGS TO THE S18P FAMILY OF FT RIBOSOMAL PROTEINS. Note that previously known as rpsR." FT /db_xref="GOA:P69230" FT /db_xref="InterPro:IPR018275" FT /db_xref="UniProtKB/Swiss-Prot:P69230" FT /protein_id="CAE55237.1" FT /translation="MAKSSKRRPAPEKPVKTRKCVFCAKKDQAIDYKDTALLRTYISER FT GKIRARRVTGNCVQHQRDIALAVKNAREVALLPFTSSVR" FT CDS 59409..59867 FT /transl_table=11 FT /gene="rplI" FT /locus_tag="Rv0056" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L9 RPLI" FT /function="BINDS TO THE 23S RRNA." FT /note="Rv0056, (MTCY21D4.19), len: 152 aa. Probable rplI, FT 50S ribosomal protein L9, equivalent to RL9_MYCLE|P46385 FT 50s ribosomal protein l9 from Mycobacterium leprae (152 FT aa), FASTA scores: opt: 847, E(): 0, (88.7% identity in 150 FT aa overlap). Also highly similar to others e.g. FT Q9X8U5|RL9_STRCO 50S RIBOSOMAL PROTEIN L9 from Streptomyces FT coelicolor (148 aa); etc. Contains PS00651 Ribosomal FT protein L9 signature. BELONGS TO THE L9P FAMILY OF FT RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66315" FT /db_xref="HSSP:1CQU" FT /db_xref="InterPro:IPR020070" FT /db_xref="UniProtKB/Swiss-Prot:P66315" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB02534.1" FT /translation="MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQK FT QADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVAAI FT KKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS" FT misc_feature 59445..59528 FT /note="PS00651 Ribosomal protein L9 signature" FT CDS 59896..60417 FT /transl_table=11 FT /locus_tag="Rv0057" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0057, (MTCY21D4.20), len: 173 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64679" FT /protein_id="CAB02535.1" FT /translation="MPVVTAVGRRRGFAMPWVSTARSGAVMLANYSAGVCGRVSSPGLN FT VRKMCLKANTPGAVTWLDTPKRFLSTQTASRCMAVNSSDVVTGRIDPQVLHTPLNTDVD FT GYAHAMHSSINSGPLEYLPATFSVFPALGDVGDLGGGVGAATYALDRLSNMRSGACVGG FT GESPWRSLMT" FT CDS 60396..63020 FT /transl_table=11 FT /gene="dnaB" FT /locus_tag="Rv0058" FT /product="PROBABLE REPLICATIVE DNA HELICASE DNAB" FT /function="PARTICIPATES IN INITIATION AND ELONGATION DURING FT CHROMOSOME REPLICATION; IT EXHIBITS DNA-DEPENDENT ATPASE FT ACTIVITY. THE INTEIN IS AN ENDONUCLEASE (POTENTIAL)." FT /EC_number="3.6.1.-" FT /note="Rv0058, (MTV030.01, MTCY21D4.21), len: 874 aa. FT Probable dnaB, replicative DNA helicase (EC 3.6.1.-). FT Contains an intein (position 61630..62838) similar to, and FT in the same position as, those in Sycnechocystis and FT Rhodothermus marinus (see citation below). Highly similar FT to others e.g. DNAB_SYNY3|Q55418 replicative dna helicase FT (872 aa), FASTA scores: opt: 533, E(): 0, (32.5% identity FT in 424 aa overlap). Also similar to intein FT recA|E1173867|AL008967 RECA INTEIN from Mycobacterium FT tuberculosis (442 aa), FASTA scores: E(): 3.8e-16, (27.0% FT identity in 426 aa overlap). C-terminal extein (position FT 62839..63015) similar to many dnaB proteins e.g. FT NP_302709.1|NC_002677|P46394|DNAB_MYCLE REPLICATIVE DNA FT HELICASE from Mycobacterium leprae (604 aa); FT DNAB_ECOLI|P03005 replicative dna helicase from Escherichia FT coli (471 aa), FASTA scores: opt: 148, E(): 1.5e-07, (37.9% FT identity in 58 aa overlap); etc. THIS PROTEIN UNDERGOES A FT PROTEIN SELF SPLICING THAT INVOLVES A POST-TRANSLATIONAL FT EXCISION OF THE INTERVENING REGION (INTEIN) FOLLOWED BY FT PEPTIDE LIGATION. BELONGS TO THE HELICASE FAMILY, DNAB FT SUBFAMILY. IN THE INTEIN SECTION; BELONGS TO THE HOMING FT ENDONUCLEASE FAMILY." FT /db_xref="GOA:P71715" FT /db_xref="InterPro:IPR006142" FT /db_xref="PDB:2R5U" FT /db_xref="UniProtKB/Swiss-Prot:P71715" FT /protein_id="CAB02519.1" FT /translation="MAVVDDLAPGMDSSPPSEDYGRQPPQDLAAEQSVLGGMLLSKDAI FT ADVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRRIGGAPYLH FT TLISTVPTAANAGYYASIVAEKALLRRLVEAGTRVVQYGYAGAEGADVAEVVDRAQAEI FT YDVADRRLSEDFVALEDLLQPTMDEIDAIASSGGLARGVATGFTELDEVTNGLHPGQMV FT IVAARPGVGKSTLGLDFMRSCSIRHRMASVIFSLEMSKSEIVMRLLSAEAKIKLSDMRS FT GRMSDDDWTRLARRMSEISEAPLFIDDSPNLTMMEIRAKARRLRQKANLKLIVVDYLQL FT MTSGKKYESRQVEVSEFSRHLKLLAKELEVPVVAISQLNRGPEQRTDKKPMLADLRESG FT CLTASTRILRADTGAEVAFGELMRSGERPMVWSLDERLRMVARPMINVFPSGRKEVFRL FT RLASGREVEATGSHPFMKFEGWTPLAQLKVGDRIAAPRRVPEPIDTQRMPESELISLAR FT MIGDGSCLKNQPIRYEPVDEANLAAVTVSAAHSDRAAIRDDYLAARVPSLRPARQRLPR FT GRCTPIAAWLAGLGLFTKRSHEKCVPEAVFRAPNDQVALFLRHLWSAGGSVRWDPTNGQ FT GRVYYGSTSRRLIDDVAQLLLRVGIFSWITHAPKLGGHDSWRLHIHGAKDQVRFLRHVG FT VHGAEAVAAQEMLRQLKGPVRNPNLDSAPKKVWAQVRNRLSAKQMMDIQLHEPTMWKHS FT PSRSRPHRAEARIEDRAIHELARGDAYWDTVVEITSIGDQHVFDGTVSGTHNFVANGIS FT LHNSLEQDADVVILLHRPDAFDRDDPRGGEADFILAKHRNGPTKTVTVAHQLHLSRFAN FT MAR" FT misc_feature 61071..61094 FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS 63200..63892 FT /transl_table=11 FT /locus_tag="Rv0059" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0059, (MTV030.02), len: 230 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O53604" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16240.1" FT /translation="MITRYKPESGFVARSGGPDRKRPHDWIVWHFTHADNLPGIITAGR FT LLADSAVTPTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSPMLYVVCKG FT HSGYSGGAGPLVHLGVALGDIIDADLTWCASDGNAAASYTKFSRQVDTLGTFVDFDLLC FT QRQWHNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYNTETMTRVRTLLDPVGGVRKY FT VIKPGMYY" FT CDS 63909..64967 FT /transl_table=11 FT /locus_tag="Rv0060" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0060, (MTV030.03), len: 352 aa. Conserved FT hypothetical protein, showing weak similarity to FT NP_104623.1|NC_002678 hypothetical protein from FT Mesorhizobium loti (155 aa); and AP000062|AP000062_92 FT hypothetical protein from Aeropyrum pernix (194 aa), FASTA FT scores: opt: 186, E(): 4.2e-05, (30.9% identity in 165 aa FT overlap)." FT /db_xref="InterPro:IPR002589" FT /db_xref="UniProtKB/TrEMBL:O53605" FT /protein_id="CAA16241.1" FT /translation="MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFTA FT YEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRVIR FT ELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVEGLR FT MTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFTPGRY FT GPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAAADRVS FT AAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGRIYSDDR FT IGVALDRILMTA" FT CDS 64991..65416 FT /transl_table=11 FT /locus_tag="Rv0061" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0061, (MTV030.04), len: 141 aa (questionable ORF). FT Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:O53606" FT /protein_id="CAA16242.1" FT /translation="MCADAQPSGSVGLLGRNCPTATTRWRRAGEGLTAADTIEVKLWAG FT KPRLHPLVPKRAVGVLLAVAHGQVAKTPSATRAIAFRHVRLMRVRWICAGNRGRKHKRR FT CTTQYRSTQASKLQLHFKLRQTLNRLGGLQAMVSACG" FT CDS 65552..66694 FT /transl_table=11 FT /gene="celA1" FT /locus_tag="Rv0062" FT /standard_name="celA" FT /product="POSSIBLE CELLULASE CELA1 (ENDOGLUCANASE) FT (ENDO-1,4-BETA-GLUCANASE) (FI-CMCASE) (CARBOXYMETHYL FT CELLULASE)" FT /function="THE BIOLOGICAL CONVERSION OF CELLULOSE TO FT GLUCOSE GENERALLY REQUIRES THREE TYPES OF HYDROLYTIC FT ENZYMES: (1) ENDOGLUCANASES WHICH CUT INTERNAL FT BETA-1,4-GLUCOSIDIC BONDS; (2) EXOCELLOBIOHYDROLASES THAT FT CUT THE DISSACCHARIDE CELLOBIOSE FROM THE NONREDUCING END FT OF THE CELLULOSE POLYMER CHAIN; (3) BETA-1,4-GLUCOSIDASES FT WHICH HYDROLYZE THE CELLOBIOSE AND OTHER SHORT FT CELLO-OLIGOSACCHARIDES TO GLUCOSE [CATALYTIC FT ACTIVITY:Endohydrolysis of 1,4-beta-D-glucosidic linkages FT in cellulose]." FT /EC_number="3.2.1.4" FT /note="Rv0062, (MTV030.05), len: 380 aa. Possible celA1, FT cellulase (EC 3.2.1.4), similar to many e.g. FT AB65568.1|AL136058 putative secreted endoglucanase FT (cellulase) from Streptomyces coelicolor (332 aa); FT P07984|GUNA_CELFI ENDOGLUCANASE A PRECURSOR from FT Cellulomonas fimi (449 aa); GUN1_STRHA|P33682 endoglucanase FT 1 precursor (cellulase) from STREPTOMYCES HALSTEDII (321 FT aa), FASTA scores: opt: 702, E(): 1. 2e-27, (38.9% identity FT in 319 aa overlap); etc. SEEMS TO BELONG TO CELLULASE FT FAMILY B (FAMILY 6 OF GLYCOSYL HYDROLASES). Note that FT previously known as celA." FT /db_xref="GOA:Q79G13" FT /db_xref="InterPro:IPR016288" FT /db_xref="PDB:1UOZ" FT /db_xref="UniProtKB/TrEMBL:Q79G13" FT /protein_id="CAE55238.1" FT /translation="MTRRTGQRWRGTLPGRRPWTRPAPATCRRHLAFVELRHYFARVMS FT SAIGSVARWIVPLLGVAAVASIGVIADPVRVVRAPALILVDAANPLAGKPFYVDPASAA FT MVAARNANPPNAELTSVANTPQSYWLDQAFPPATVGGTVARYTGAAQAAGAMPVLTLYG FT IPHRDCGSYASGGFATGTDYRGWIDAVASGLGSSPATIIVEPDALAMADCLSPDQRQER FT FDLVRYAVDTLTRDPAAAVYVDAGHSRWLSAEAMAARLNDVGVGRARGFSLNVSNFYTT FT DEEIGYGEAISGLTNGSHYVIDTSRNGAGPAPDAPLNWCNPSGRALGAPPTTATAGAHA FT DAYLWIKRPGESDGTCGRGEPQAGRFVSQYAIDLAHNAGQ" FT CDS 66923..68362 FT /transl_table=11 FT /locus_tag="Rv0063" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0063, (MTV030.06), len: 479 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to many e.g. FT HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase from FT Arthrobacter oxidans (458 aa), FASTA scores: opt: 343, E(): FT 3.4e-13, (27.4% identity in 467 aa overlap); FT AAD28454.1|AF127374_9|AF127374|MitR oxidase from FT Streptomyces lavendulae (514 aa); AAF81732.1|AF254925|EncM FT putative FAD-dependent oxygenase from Streptomycesmaritimus FT (464 aa); etc. Also similar to Mycobacterium tuberculosis FT proteins e.g. Rv3107c, Rv1257c, etc. Contains PS00862 FT Oxygen oxidoreductases covalent FAD-binding site." FT /db_xref="GOA:O53608" FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/TrEMBL:O53608" FT /protein_id="CAA16244.1" FT /translation="MAREISRQTFLRGAAGALAAGAVFGSVRATADPAASGWEALSSAL FT GGKVLQPDDGPQFATAKQVFNTNYNGYTPAVIVTPTSQLDVQKAMAFAAANNLKVAPRG FT GGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTVTPATGLYAMHQVLAAAGRGIPT FT GTCPTVGVAGHALGGGLGANSRHAGLLCDQLTSASVVLPSGQAVTASATDHPDLFWALR FT GGGGGNFGVTTSLTFATFPSGDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSWALADA FT TVDPLGTHCRILATCPAGSGGSVAAAIVSAVGTQPTGTENHTFNYLDLVRYLAVGNLNP FT SPLGYVGGSDVFTTITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVSPGATAFP FT WRRQSALVQWYVETSGSPSEATSWLNTAHQAVRAYSVGGYVNYLEVNQPPARYFGPNLS FT RLSAVRQKYDPSRVMFSGLNF" FT misc_feature 67142..67243 FT /note="PS00862 Oxygen oxidoreductases covalent FAD-binding FT site" FT CDS 68620..71559 FT /transl_table=11 FT /locus_tag="Rv0064" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0064, (MTV030.07), len: 979 aa. Probable conserved FT transmembrane protein, highly similar to NP_301532.1| FT (NC_002677) putative integral membrane protein from FT Mycobacterium leprae (983 aa). Also similar to other FT hypothetical proteins from ARCHAEOGLOBUS FULGIDUS and FT Synecocystis sp. e.g. P72637|D90899 HYPOTHETICAL 117.2 kDa FT PROTEIN from SYNECHOCYSTIS SP. (1032 aa), FASTA scores: FT opt: 1004, E(): 3.6e-32, (31.0 % identity in 848 aa FT overlap); and CAC01334.1|AL390968 putative integral FT membrane protein (fragment) from Streptomyces coelicolor FT (815 aa); etc. Also similar to Rv3193c from Mycobacterium FT tuberculosis (992 aa), FASTA score: (50.3% identity in 985 FT aa overlap). Contains probable coiled-coil domain from aa FT 948 to 976." FT /db_xref="GOA:O53609" FT /db_xref="InterPro:IPR005372" FT /db_xref="UniProtKB/Swiss-Prot:O53609" FT /protein_id="CAA16245.1" FT /translation="METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWLW FT FGEVGFRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDPVAPL FT RSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIVDPEFGYDIGFFVF FT DLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTTGRGMLTQAARVQLAVFAGAVVL FT LKAVAYWLDRYELLSSGRKEPTFTGAGYTDIHAELPAKLVLVAIAVLCAVSFFTAIFLR FT DLRIPAMAAALLVLSAILVGGLWPLLMEQFSVRPNAADVERPYIQRNIEATREAYRIGG FT DWVQYRSYPGIGTKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFSFAEILDI FT DRYRIDGELQDYIVGVRELSPKSLTGNQTDWINKHTVYTHGNGFVAAPANRVNAAARGA FT ENISDSNSGYPIYAVSDIASLGSGRQVIPVEQPRVYYGEVIAQADPDYAIVGGAPGSAP FT REYDTDTSKYTYTGAGGVSIGNWFNRTVFATKVAQHKFLFSREIGSESKVLIHRDPKER FT VQRVAPWLTTDDNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPVTSPTGIVRQGK FT QVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSEDQIPDELRAHFRY FT PEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNNANATQPPFYVLVGDQQSAQP FT SFRLASAMVGYNREFLSAYISAHSDPANYGKLTVLELPTDTLTQGPQQIQNSMISDTRV FT ASERTLLERSNRIHYGNLLSLPIADGGVLYVEPLYTERISTSPSSSTFPQLSRVLVSVR FT EPRTEGGVRVGYAPTLAESLDQVFGPGTGRVATARGGDAASAPPPGAGGPAPPQAVPPP FT RTTQPPAAPPRGPDVPPATVAELRETLADLRAVLDRLEKAIDAAETPGG" FT CDS 71821..72222 FT /transl_table=11 FT /locus_tag="Rv0065" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0065, (MTV030.08), len: 133 aa. Conserved FT hypothetical protein, similar to several hypothetical FT proteins from Mycobacterium tuberculosis: Rv0960 (127 aa), FT Rv1720c (129 aa), and Rv0549c (137 aa)." FT /db_xref="UniProtKB/TrEMBL:O53610" FT /protein_id="CAA16246.1" FT /translation="MDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVG FT HALRRAVLSDEISEEQARAALDALPYLIDNRYPHSPRLIEYTWQLRHNVTFYDALYVAL FT ATALDVPLLTGDSRLAAAPGLPCEIKLVR" FT CDS complement(72274..74511) FT /transl_table=11 FT /gene="icd2" FT /locus_tag="Rv0066c" FT /product="PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 FT (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) FT (IDP)" FT /function="INVOLVED IN THE KREBS CYCLE [CATALYTIC ACTIVITY: FT Isocitrate + NADP+ = 2-OXOGLUTARATE + CO(2) + NADPH]." FT /EC_number="1.1.1.42" FT /note="Rv0066c, (MTV030.09c), len: 745 aa. Probable icd2, FT isocitrate dehydrogenase NADP-dependent (EC 1.1.1.42), FT equivalent to NP_302705.1|NC_002677 isocitrate FT dehydrogenase [NADP] from Mycobacterium leprae (746 aa). FT Also highly similar to many members of the monomeric-type FT family of IDH e.g. NP_251314.1|NC_002516 isocitrate FT dehydrogenase from Pseudomonas aeruginosa (741 aa); FT IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from FT Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106, FT E(): 0, (61.4% identity in 735 aa overlap); FT NP_230786.1|NC_002505 isocitrate dehydrogenase from Vibrio FT cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE FT FAMILY OF IDH." FT /db_xref="GOA:O53611" FT /db_xref="HSSP:1ITW" FT /db_xref="InterPro:IPR004436" FT /db_xref="UniProtKB/TrEMBL:O53611" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16247.1" FT /translation="MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDIS FT VAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQD FT KGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHS FT MGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGD FT VIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAF FT AKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGI FT SNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNG FT QFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDI FT WRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGL FT DIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMA FT GGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKT FT LDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVL FT TKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAALEAVQG" FT CDS complement(74629..75198) FT /transl_table=11 FT /locus_tag="Rv0067c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0067c, (MTV030.10c), len: 189 aa. Possible FT transcriptional regulator, highly similar except in FT N-terminus to T44726 probable transcription regulator from FT Mycobacterium leprae (189 aa), FASTA scores: opt: 829, E(): FT 0, (68.3% identity in 189 aa overlap). And similar to FT others, often many members of the tetR family, e.g. T36918 FT probable transcription regulator from Streptomyces FT coelicolor (202 aa); NP_535866.1|NC_003306 transcriptional FT regulator TetR family from Agrobacterium tumefaciens strain FT C58 (Dupont) (194 aa); UIDR_ECOLI|Q59431 uid operon FT repressor (gus operon repressor) from Escherichia coli (196 FT aa), FASTA scores: opt: 200, E(): 7.2e-06, (24.7% identity FT in 186 aa overlap); etc. Also similar to MTCY8D5_28 from FT Mycobacterium tuberculosis cosmid (229 aa), FASTA score: FT (32.7% identity in 168 aa overlap). Contains probable FT helix-turn-helix motif from aa 34 to 55 (Score 1523, +4.37 FT SD)." FT /db_xref="GOA:O53612" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:O53612" FT /protein_id="CAA16248.1" FT /translation="MAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGV FT GAGTVYRHFPTKEALFQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATD FT RGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQ FT AMQSYNAELAAKVTDVALDGLRANRK" FT CDS 75301..76212 FT /transl_table=11 FT /locus_tag="Rv0068" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0068, (MTV030.11), len: 303 aa. Probable FT oxidoreductase (EC 1.-.-.-), equivalent to FT NP_301343.1|NC_002677 putative oxidoreductase from FT Mycobacterium leprae (304 aa). Also highly similar to many FT e.g. NP_485762.1|NC_003272 probable oxidoreductase from FT Nostoc sp. PCC 7120 (311 aa); NP_279536.1|NC_002607|YajO1 FT probable oxidoreductase from Halobacterium sp. NRC-1 (316 FT aa); OXIR_STRAT|Q03326 probable oxidoreductase from FT Streptomyces antibioticus (298 aa), FASTA scores: opt: 430, FT E(): 1.3e-16, (34.9% identity in 295 aa overlap); etc. Also FT highly similar to MTV037_3 and MTV022_13 from Mycobacterium FT tuberculosis." FT /db_xref="GOA:O53613" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O53613" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16249.1" FT /translation="MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVLAV FT RNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAGVM FT YTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIHFDD FT LQWERRYRRVAAYGQAKLANLLFTYELQRRLAPGGTTIAVASHPGVSNTEVVRNMPRPL FT VAVAAILAPLMQDAELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASSAQSHD FT EQLQRRLWAVSEELTGVVYPVG" FT CDS complement(76237..77622) FT /transl_table=11 FT /gene="sdaA" FT /locus_tag="Rv0069c" FT /product="PROBABLE L-SERINE DEHYDRATASE SDAA (L-SERINE FT DEAMINASE) (SDH) (L-SD)" FT /function="INVOLVED IN GLUCONEOGENESIS FROM SERINE FT [CATALYTIC ACTIVITY: L-serine + H2O = pyruvate + NH3 + FT H2O]." FT /EC_number="4.3.1.17" FT /note="Rv0069c, (MTV030.12c), len: 461 aa. Probable sdaA, FT L-serine dehydratase (EC 4.2.1.13), equivalent to FT NP_302203.1| NC_002677 L-serine dehydratase from FT Mycobacterium leprae (458 aa). Also highly similar to many FT e.g. NP_251133.1|NC_002516 L-serine dehydratase from FT Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO L-SERINE FT DEHYDRATASE from Streptomyces coelicolor (455 aa); FT SDHL_ECOLI|P16095 L-serine dehydratase 1 from Escherichia FT coli (454 aa), FASTA scores: opt: 1381, E(): 0, (51.1% FT identity in 460 aa overlap); etc. BELONGS TO THE FT IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY. FT COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE)." FT /db_xref="GOA:P66773" FT /db_xref="InterPro:IPR005131" FT /db_xref="UniProtKB/Swiss-Prot:P66773" FT /protein_id="CAA16250.1" FT /translation="MTISVFDLFTIGIGPSSSHTVGPMRAANQFVVALRRRGHLDDLEA FT MRVDLFGSLAATGAGHGTMSAILLGLEGCQPETITTEHKERRLAEIAASGVTRIGGVIP FT VPLTERDIDLHPDIVLPTHPNGMTFTAAGPHGRVLATETYFSVGGGFIVTEQTSGNSGQ FT HPCSVALPYVSAQELLDICDRLDVSISEAALRNETCCRTENEVRAALLHLRDVMVECEQ FT RSIAREGLLPGGLRVRRRAKVWYDRLNAEDPTRKPEFAEDWVNLVALAVNEENASGGRV FT VTAPTNGAAGIVPAVLHYAIHYTSAGAGDPDDVTVRFLLTAGAIGSLFKERASISGAEV FT GCQGEVGSAAAMAAAGLAEILGGTPRQVENAAEIAMEHSLGLTCDPIAGLVQIPCIERN FT AISAGKAINAARMALRGDGIHRVTLDQVIDTMRATGADMHTKYKETSAGGLAINVAVNI FT VEC" FT CDS complement(77619..78896) FT /transl_table=11 FT /gene="glyA2" FT /locus_tag="Rv0070c" FT /product="PROBABLE SERINE HYDROXYMETHYLTRANSFERASE GLYA2 FT (SERINE METHYLASE 2) (SHMT 2)" FT /function="KEY ENZYME IN THE BIOSYNTHESIS OF PURINES, FT LIPIDS, OTHER COMPONENTS. INTERCONVERSION OF SERINE AND FT GLYCINE [CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate FT + glycine + H2O = tetrahydrofolate + L-serine]." FT /EC_number="2.1.2.1" FT /note="Rv0070c, (MTV030.13c), len: 425 aa. Probable glyA2, FT serine hydroxymethyltransferase (EC 2.1.2.1), equivalent to FT NP_302318.1|NC_002677 serine hydroxymethyltransferase from FT Mycobacterium leprae (426 aa). Also highly similar to many FT e.g. O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE from FT Streptomyces coelicolor (420 aa); FT AAK60516.1|AF327063_1|AF327063 serine FT hydroxymethyltransferase from Corynebacterium glutamicum FT (434 aa); GLYA_ECOLI|P00477 serine hydroxymethyltransferase FT from Escherichia coli (417 aa), FASTA scores: opt: 1462, FT E(): 0, (54.3% identity in 416 aa overlap); etc. Also FT highly similar to MTV017_46 from Mycobacterium FT tuberculosis. Contains PS00096 Serine FT hydroxymethyltransferase pyridoxal-phosphate attachment FT site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL FT PHOSPHATE." FT /db_xref="GOA:O53615" FT /db_xref="HSSP:1DFO" FT /db_xref="InterPro:IPR019798" FT /db_xref="UniProtKB/Swiss-Prot:O53615" FT /protein_id="CAA16251.1" FT /translation="MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVMQ FT AQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATANAA FT TMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVAEAA FT RTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPVPHAH FT VVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLEHVIAAKATAFKMAAQP FT EFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAEDR FT LAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAAALTATND FT DQLGPLRAQVQRLAARYPLYPELHRT" FT misc_feature complement(78183..78233) FT /note="PS00096 Serine hydroxymethyltransferase FT pyridoxal-phosphate attachment site" FT CDS 79486..80193 FT /transl_table=11 FT /locus_tag="Rv0071" FT /product="POSSIBLE MATURASE" FT /function="UNKNOWN" FT /note="Rv0071, (MTV030.14), len: 235 aa. Possible maturase, FT similar to many proteins of the group II intron maturase FT family e.g. P95451|U77945 MATURASE-RELATED PROTEIN from FT PSEUDOMONAS ALCALIGENES (297 aa), FASTA scores: opt: 395, FT E(): 1.7e-20, (43.5% identity in 147 aa overlap); FT N-terminus of AAD16434.1|AF101076 maturase-related protein FT from Pseudomonas putida (473 aa); N-terminus of FT NP_437373.1|NC_003078 putative reverse FT transcriptasematurase protein from Sinorhizobium meliloti FT (453 aa); etc. Also similar to MLCL581_1 from Mycobacterium FT leprae. Contains 5 VDP repeats at N-terminus, these are FT also found in two Streptococcus plasmid hypothetical FT proteins Q52246|X17092 and Q54942|X66468." FT /db_xref="GOA:O53616" FT /db_xref="InterPro:IPR000477" FT /db_xref="UniProtKB/TrEMBL:O53616" FT /protein_id="CAA16252.1" FT /translation="MSSITVSVDPVDPVDPVDPVDPVDAVVAAGSDGLTVARIESEIGA FT LEFLNELRTELKSGQFRPQPVRERKIPKPGGLGKVRRLGIPTVADRVVQAALKLVLEPI FT FETDFEPVSYGFRPARRAHDTIAEIHLFGTQEYRWVLDADIKACFDRIDHADLMDRVRH FT RIKDKRVLRLVNWQRIRHRWNWTDVRRWLTDPTGRWHPISADGITLFNPAAVPIRRYRY FT RGNTIPTPWTQAV" FT repeat_region 79507..79551 FT /note="5 x 9 bp GTGGACCCG repeats" FT repeat_region 80236..80550 FT /label=REP'-1 FT /rpt_type=DIRECT FT /note="(MTV030.15), len: 315 bp. Probable REP'-1 pseudogene FT fragment, similar to many Mycobacterium tuberculosis FT proteins inside REP13E12 elements e.g. FT Q50655|Z95390|MTCY13E12.20 (317 aa), FASTA scores; opt: 324 FT E(): 6.8e-17, 43.4% identity in 99 aa overlap, but no FT possible startsite." FT CDS 80624..81673 FT /transl_table=11 FT /locus_tag="Rv0072" FT /product="PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE FT PROTEIN ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT GLUTAMINE ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv0072, (MTV030.16), len: 349 aa. Probable FT glutamine-transport transmembrane protein ABC-transporter FT (see citation below), showing weak similarity to FT NP_465894.1|NC_003210 protein similar to putative FT ABC-transporter transmembrane subunit from Listeria FT monocytogenes EGD-e (367 aa); NP_471800.1|NC_003212 protein FT similar to putative ABC-transporter transmembrane subunit FT from Listeria innocua (367 aa); E1204111|AJ003195 MEMBRANE FT SPANNING SUBUNIT DEVC from ANABAENA VARIABILIS (385 aa), FT FASTA scores: opt: 155, E(): 8.1e-07, (22.0% identity in FT 381 aa overlap). Also highly similar to FT Rv2563|Y0A5_MYCTU|Q50735|MTCY9C4.05c from Mycobacterium FT tuberculosis (388 aa), FASTA scores: E(): 0, (76.2% FT identity in 349 aa overlap). Note that supposed act with FT near ORF Rv0073|MTV030.17 ATP-binding protein FT ABC-transporter." FT /db_xref="GOA:O53617" FT /db_xref="InterPro:IPR003838" FT /db_xref="UniProtKB/TrEMBL:O53617" FT /protein_id="CAA16253.1" FT /translation="MLFAALRDMQWRKRRLVITIISTGLIFGMTLVLTGLANGFRVEAR FT HTVDSMGVDVFVVRSGAAGPFLGSIPFPDVDLARVAAEPGVMAAAPLGSVGTIMKEGTS FT TRNVTVFGAPEHGPGMPRVSEGRSPSKPDEVAASSTMGRHLGDTVEVGARRLRVVGIVP FT NSTALAKIPNVFLTTEGLQKLAYNGQPNITSIGIIGMPRQLPEGYQTFDRVGAVNDLVR FT PLKVAVNSISIVAVLLWIVAVLIVGSVVYLSALERLRDFAVFKAIGTPTRSIMAGLALQ FT ALVIALLAAVVGVVLAQVLAPLFPMIVAVPVGAYLALPVAAIVIGLFASVAGLKRVVTV FT DPAQAFGGP" FT CDS 81676..82668 FT /transl_table=11 FT /locus_tag="Rv0073" FT /product="PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT GLUTAMINE ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv0073, (MTV030.17), len: 330 aa. Probable FT glutamine-transport ATP-binding protein ABC-transporter FT (see citation below), similar to many ATP-binding proteins FT e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding FT protein from Archaeoglobus fulgidus (231 aa); T34822 FT ABC-transporter ATP binding protein from Streptomyces FT coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC FT transporter ATP-binding protein from Escherichia coli (648 FT aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity FT in 233 aa overlap); etc. Also highly similar to FT Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter FT ATP-binding protein from Mycobacterium tuberculosis (330 FT aa), FASTA scores: E(): 0, (83.3% identity in 330 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), PS00211 ABC transporters family signature, and FT PS00889 Cyclic nucleotide-binding domain signature 2. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS). Note that supposed act with near ORF FT Rv0072|MTV030.16 transmembrane ABC-transporter." FT /db_xref="GOA:O53618" FT /db_xref="HSSP:1B0U" FT /db_xref="InterPro:IPR018488" FT /db_xref="UniProtKB/TrEMBL:O53618" FT /protein_id="CAA16254.1" FT /translation="MGDLSIQNLVVEYYSGGYALRPINGLNLDVAAGSLVMLLGPSGCG FT KTTLLSCLGGILRPKSGAIKFDEVDITTLQGAELANYRRNKVGIVFQAFNLVPSLTAVE FT NVMVPLRSAGMSRRASRRRAEELLARVNLAERMNHRPGDLSGGQQQRVAVARAIALDPP FT LILADEPTAHLDFIQVEEVLRLIRELADGERVVVVATHDSRMLPMADRVVELTPDFAET FT NRPPETVHLQAGEVLFEQSTMGDLIYVVSEGEFEIVHELADGGEELVKVAGPGDYFGEI FT GVLFHLPRSATVRARSDATAVGYTVQAFRERLGVGGLRDLIEHRALAND" FT misc_feature 81793..81816 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 82105..82149 FT /note="PS00211 ABC transporters family signature" FT misc_feature 82507..82560 FT /note="PS00889 Cyclic nucleotide-binding domain signature FT 2" FT CDS 82748..83983 FT /transl_table=11 FT /locus_tag="Rv0074" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0074, (MTV030.18), len: 411 aa. Conserved FT hypothetical protein, similar to Rv2915c|MTCY338.03c FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis, and showing some simlarity to various enzymes FT or hypothetical proteins from other organisms, eg FT NP_243801.1|NC_002570 aryldialkylphosphatase from Bacillus FT halodurans (394 aa); NP_421471.1|NC_002696 putativ Xaa-Pro FT dipeptidase from Caulobacter crescentus (429 aa); FT NP_343436.1|NC_002754 Prolidase (Xaa-Pro dipeptidase) FT (pepQ-like2) from Sulfolobus solfataricus (408 aa); FT Q50432|M91040 ORGANO PHOSPHATE ACID ANHYDRASE OPAB from FT MYCOBACTERIUM SP. (409 aa), FASTA scores: opt: 166, E(): FT 3.9e-11, (31.2% identity in 430 aa overlap); etc." FT /db_xref="GOA:O53619" FT /db_xref="InterPro:IPR006680" FT /db_xref="UniProtKB/TrEMBL:O53619" FT /protein_id="CAA16255.1" FT /translation="MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISA FT VDFAGSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAGDPHAVLVGRARRHA FT AAALRSGITTIRDLGDRDYAALALREEYRQKTTVGPELVVSGPPLTRSGGHCWFLGGVA FT DSVEELVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGLP FT VTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVWCGMTIPRVYP FT EMPENLVAVVQDGWRNIRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSRHGFTST FT EVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVWRSGTQVP FT LQASAVGYNTPS" FT CDS 83996..85168 FT /transl_table=11 FT /locus_tag="Rv0075" FT /product="PROBABLE AMINOTRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="2.6.1.-" FT /note="Rv0075, (MTV030.19), len: 390 aa. Probable FT aminotransferase (EC 2.6.1.-), similar to many CLASS-II FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES (MALY/PATB FT SUBFAMILY) e.g. NP_302217.1|NC_002677 aminotransferase from FT Mycobacterium leprae (402 aa); PATB_BACSU|Q08432 putative FT aminotransferase b from Bacillus subtilis (387 aa), FASTA FT scores: opt: 684, E(): 5.4e-33, (31.3% identity in 384 aa FT overlap); etc. Also similar to several cystathionine FT beta-lyase (beta C-S lyase) e.g. FT AAK69425.1|AF276227_1|AF276227 from Corynebacterium FT glutamicum (368 aa); etc. Also similar to other proteins FT from Mycobacterium tuberculosis e.g. Rv2294, Rv0858c, etc." FT /db_xref="GOA:O53620" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/TrEMBL:O53620" FT /protein_id="CAA16256.1" FT /translation="MQDSIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPAV FT LDGVRACVDNEEFGYPPLGEDSLPRATADWCRQRYGWCPRPDWVRVVPDVLKGMEVVVE FT FLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQQDSGRYLLDLDALQAAFVRGAG FT SVIICNPNNPLGTAFTEAELRAIVDIAARHGARVIADEIWAPVVYGSRHVAAASVSEAA FT AEVVVTLVSASKGWNLPGLMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRANIAAYH FT HGESWLDELLPYLRANRDHLARALPELAPGVEVNAPDGTYLSWVDFRALALPSEPAEYL FT LSKAKVALSPGIPFGAAVGSGFARLNFATTRAILDRAIEAIAAALRDIID" FT CDS complement(85183..85572) FT /transl_table=11 FT /locus_tag="Rv0076c" FT /product="PROBABLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0076c, (MTV030.20c), len: 129 aa. Probable FT membrane protein, with membrane-spanning domain at FT C-terminus." FT /db_xref="UniProtKB/TrEMBL:O53621" FT /protein_id="CAA16257.1" FT /translation="MPAVTTPSNHWGDERRKLSHQPPVRGQILGRRQARRLSQHFARVG FT VEAPPKRLQEMLLGAPAADEEWTDVKFALIVTQLNHEKRVAKFHRLQRRATHSLICLGL FT VLVALNFLICLAYIFFSLTQHAAAL" FT CDS complement(85636..86466) FT /transl_table=11 FT /locus_tag="Rv0077c" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0077c, (MTV030.21c), len: 276 aa. Possible FT oxidoreductase (EC 1.-.-.-), weakly similar to others e.g. FT CAC44600.1|AL596162 putative oxidoreductase from FT Streptomyces coelicolor (275 aa); P33912|BPA1_STRAU FT NON-HAEM BROMOPEROXIDASE BPO-A1 (BROMIDE PEROXIDASE) (EC FT 1.11.1.-) from Streptomyces aureofaciens (275 aa); FT BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from FT Streptomyces aureofaciens (274 aa), FASTA scores: opt: 230, FT E(): 1.5e-07, (26.1% identity in 249 aa overlap); etc. Also FT similar to MTCY05A6_35 and MTCY1A11_10 from Mycobacterium FT tuberculosis. And shows some similarity in part with FT AAL17935.1|AY054120 putative epoxide hydrolase from FT Mycobacterium smegmatis (203 aa)." FT /db_xref="GOA:O53622" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:O53622" FT /protein_id="CAA16258.1" FT /translation="MSTIDISAGTIHYEATGPETGRPVVFVHGYMMGGQLWRRVSERLA FT GRGLRCIAPTWPLGAHPKPLRPGADQTIGGVAGIVADVLAALELKDVVLVGNDTGGVVT FT QLVAVHYPERLGALVLTSCDAFEHFPPPILKPVILAAKSATLFRAAIQVMRAPAARNRA FT YAGLSHHNIDHLTRAWVRPALSNPAIAEDLRQLSLSLRTEVTTAVAARLPEFDKPALIA FT WSADDVFFALENGQRLAATIPRARFEVIEGARTFSMVDSPDRLADQLSTVAVRT" FT CDS 86528..87133 FT /transl_table=11 FT /locus_tag="Rv0078" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0078, (MTV030.22), len: 201 aa. Probable FT transcriptional regulator, equivalent to FT NP_302706.1|NC_002677 putative TetR-family transcriptional FT regulator from Mycobacterium leprae (236 aa), FASTA scores: FT opt: 755, E(): 0, (71.4% identity in 175 aa overlap). Also FT similar to others e.g. NP_103770.1|NC_002678 probable FT transcriptional regulator from Mesorhizobium loti (208 aa); FT NP_384275.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR FT PROTEIN from Sinorhizobium meliloti (197 aa); FT NP_250960.1|NC_002516 probable transcriptional regulator FT from Pseudomonas aeruginosa (196 aa); etc. Also similar to FT TETC_ECOLI|P28815 transposon tn10 tetc protein from FT Escherichia coli (197 aa), FASTA scores: opt: 181, E(): FT 9.7e-05, (24.8% identity in 165 aa overlap). Contains FT probable helix-turn-helix motif from aa 35 to 56 (Score FT 1348, +3.78 SD)." FT /db_xref="GOA:O53623" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:O53623" FT /protein_id="CAA16259.1" FT /translation="MEIKRRTQEERSAATREALITGARKLWGLRGYAEVGTPEIATEAG FT VTRGAMYHQFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLEVS FT GDPEVRQLILLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLARQPVRPLAQVL FT IGALDEAAMFIATADDPKRARRETRQVLRRLIDGMLNG" FT CDS complement(87208..87801) FT /transl_table=11 FT /locus_tag="Rv0078A" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0078A, len: 197 aa. Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q8VKS0" FT /protein_id="CAE55239.1" FT /translation="MNAVESTLRRVAKDLTGLRQRWALVGGFAVSARSEPRFTRDVDIV FT VAVANDDAAESLVRQLLTQQYHLLASVEQDAARRLAAVRLGATADTAANVVVDLLFASC FT GIEPEIAEAAEEIEILPDLVAPVATTAHLIAMKLLARDDDRRPQDRSDLRALVDAASPQ FT DIQDARKAIELITLRGFHRDRDLAAEWTRLAAKW" FT CDS 88204..89025 FT /transl_table=11 FT /locus_tag="Rv0079" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0079, (MTV030.23), len: 273 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O53624" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16260.1" FT /translation="MEPKRSRLVVCAPEPSHAREFPDVAVFSGGRANASQAERLARAVG FT RVLADRGVTGGARVRLTMANCADGPTLVQINLQVGDTPLRAQAATAGIDDLRPALIRLD FT RQIVRASAQWCPRPWPDRPRRRLTTPAEALVTRRKPVVLRRATPLQAIAAMDAMDYDVH FT LFTDAETGEDAVVYRAGPSGLRLARQHHVFPPGWSRCRAPAGPPVPLIVNSRPTPVLTE FT AAAVDRAREHGLPFLFFTDQATGRGQLLYSRYDGNLGLITPTGDGVADGLA" FT CDS 89022..89480 FT /transl_table=11 FT /locus_tag="Rv0080" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0080, (MTV030.24), len: 152 aa. Conserved FT hypothetical protein, similar to several hypothetical FT proteins from Streptomyces coelicolor e.g. FT SCJ12.26|AL109989|SCJ12_24 from Streptomyces coelicolor FT cosmid J1 (137 aa), FASTA scores: opt: 291, E(): 4e-13, FT (46.5% identity in 129 aa overlap); etc." FT /db_xref="UniProtKB/TrEMBL:O53625" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16261.1" FT /translation="MSPGSRRASPQSAREVVELDRDEAMRLLASVDHGRVVFTRAALPA FT IRPVNHLVVDGRVIGRTRLTAKVSVAVRSSADAGVVVAYEADDLDPRRRTGWSVVVTGL FT ATEVSDPEQVARYQRLLHPWVNMAMDTVVAIEPEIVTGIRIVADSRTP" FT CDS 89575..89919 FT /transl_table=11 FT /locus_tag="Rv0081" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0081, (MTV030.25), len: 114 aa. Probable FT transcriptional regulator, highly similar to others e.g. FT AL078610|SCH35_52|T36657 probable transcription regulator FT from Streptomyces coelicolor (117 aa), FASTA scores: opt: FT 404, E(): 4.8e-22, (58.2% identity in 110 aa overlap); FT AAG02351.1|AF210249_10|AF210249 metal-dependent regulatory FT protein from Streptomyces verticillus (113 aa); FT NP_435817.1|NC_003037 Putative transcriptional regulator FT from Sinorhizobium meliloti (115 aa); etc." FT /db_xref="GOA:O53626" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:O53626" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA16262.1" FT /translation="MESEPLYKLKAEFFKTLAHPARIRILELLVERDRSVGELLSSDVG FT LESSNLSQQLGVLRRAGVVAARRDGNAMIYSIAAPDIAELLAVARKVLARVLSDRVAVL FT EDLRAGGSAT" FT CDS 89924..90403 FT /transl_table=11 FT /locus_tag="Rv0082" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0082, (MTV030.26), len: 159 aa. Probable FT oxidoreductase (EC 1.-.-.-), highly highly similar or FT similar to other various oxidoreductases e.g. FT NP_143304.1|NC_000961 NADH-ubiquinone oxidoreductase FT subunit from Pyrococcus horikoshii (173 aa); FT NP_126406.1|NC_000868 CO-induced hydrogenase related, FT subunit L from Pyrococcus abyssi (170 aa); FT HYCG_ECOLI|P16433 formate hydrogenlyase subunit 7 from FT Escherichia coli (255 aa), FASTA scores: opt: 442, E(): FT 8e-29, (43.2% identity in 148 aa overlap); etc." FT /db_xref="GOA:O53627" FT /db_xref="InterPro:IPR006137" FT /db_xref="UniProtKB/TrEMBL:O53627" FT /protein_id="CAA16263.1" FT /translation="MGWVAKIFRVGRVVEPAAPLPAAIAEPPAGVRGSLQIRHVDAGSC FT NGCEVEISGAFGPVYDAERFGARLVASPQHADALLVTGVVTHNMAGPLRKTLEATPRPR FT VVIACGDCALNRGVFADAYGVVGAVGEVVPVDVEIAGCPPTPAAIMAALRSVTGK" FT CDS 90400..92322 FT /transl_table=11 FT /locus_tag="Rv0083" FT /product="PROBABLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0083, (MTV030.27, MTCY251.01), len: 640 aa. FT Probable oxidoreductase (EC 1.-.-.-), showing some FT similarity to other various oxidoreductases e.g. FT AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B FT from Burkholderia pseudomallei (668 aa); HYFB_ ECOLI|P23482 FT hydrogenase-4 component b from Escherichia coli strain K12 FT (672 aa), FASTA scores: opt: 995, E(): 0, (32.2% identity FT in 571 aa overlap); AAF13041.1|AF157639_1|AF157639 putative FT formate hydrogenlyase integral membrane subunit from FT Desulfitobacterium dehalogenans (637 aa); etc." FT /db_xref="GOA:Q10880" FT /db_xref="InterPro:IPR003918" FT /db_xref="UniProtKB/Swiss-Prot:Q10880" FT /protein_id="CAA16264.1" FT /translation="MTAAPTAGGVVTSGVGVAGVGVGLLGMFGPVRVVHVGWLLPLSGV FT HIELDRLGGFFMALTGAVAAPVGCYLIGYVRREHLGRVPMAVVPLFVAAMLLVPAAGSV FT TTFLLAWELMAIASLILVLSEHARPQVRSAGLWYAVMTQLGFIAILVGLVVLAAAGGSD FT RFAGLGAVCDGVRAAVFMLTLVGFGSKAGLVPLHAWLPRAHPEAPSPVSALMSAAMVNL FT GIYGIVRFDLQLLGPGPRWWGLALLAVGGTSALYGVLQASVAADLKRLLAYSTTENMGL FT ITLALGAATLFADTGAYGPASIAAAAAMLHMIAHAAFKSLAFMAAGSVLAATGLRDLDL FT LGGLARRMPATTVFFGVAALGACGLPLGAGFVSEWLLVQSLIHAAPGHDPIVALTTPLA FT VGVVALATGLSVAAMTKAFGIGFLARPRSTQAEAAREAPASMRAGMAIAAGACLVLAVA FT PLLVAPMVRRAAATLPAAQAVKFTGLGAVVRLPAMSGSIAPGVIAAAVLAAALAVAVLA FT RWRFRRRPAPARLPLWACGAADLTVRMQYTATSFAEPLQRVFGDVLRPDTDIEVTHTAE FT SRYMAERITYRTAVADAIEQRLYTPVVGAVAAMAELLRRAHTGSVHRYLAYGALGVLIV FT LVVAR" FT CDS 92328..93278 FT /transl_table=11 FT /gene="hycD" FT /locus_tag="Rv0084" FT /standard_name="hevD" FT /product="POSSIBLE FORMATE HYDROGENLYASE HYCD (FHL)" FT /function="INVOLVED IN HYDROGEN METABOLISM; FHL PATHWAY." FT /EC_number="1.-.-.-" FT /note="Rv0084, (MTCY251.02), len: 316 aa. Possible hycD FT (alternate gene name: hevD), formate hydrogenlyase (EC FT 1.-.-.-), integral membrane protein, similar to others e.g. FT HYCD_ECOLI|P16430 formate hydrogenlyase subunit 4 from FT Escherichia coli (307 aa), FASTA scores: opt: 570, E(): FT 2.1e-26, (33.8% identity in 305 aa overlap); FT AAK06856.1|AF335723_2|AF335723 formate hydrogenlyase FT subunit 4 from Burkholderia pseudomallei (316 aa); FT NP_457244.1|NC_003198 formate hydrogenlyase subunit 4 from FT Salmonella enterica subsp. enterica serovar Typhi (307 aa); FT etc. Also similar to NUOH_ECOLI|P33603 NADH dehydrogenase I FT chain H from Escherichia coli (325 aa), FASTA scores: opt: FT 207, E(): 9.5e-06, (26.5% identity in 260 aa overlap). FT BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY." FT /db_xref="GOA:Q10881" FT /db_xref="InterPro:IPR001694" FT /db_xref="UniProtKB/TrEMBL:Q10881" FT /protein_id="CAA98920.1" FT /translation="MSYLAGAAQIGGVMVGAPLVIGMTRQVRARWEGRAGAGLLQPWRD FT LLKQLGKQQITPAGTTIVFAAAPVIVAGTTLLIAAIAPLVATGSPLDPSADLFAVVGLL FT FLGTVALTLAGIDTGTSFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGALVAS FT TIDHPGHVVSLAGVLAFVALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAGPRLA FT LVEWAAGMRLTVLLALLANLFLPWGIAGAAPTALDVLTGVVAVAAKVAILAVLLATFEV FT FLAKLRLFRVPELLAGSFLLALLAVTAANFFTVGA" FT CDS 93289..93951 FT /transl_table=11 FT /gene="hycP" FT /locus_tag="Rv0085" FT /product="POSSIBLE HYDROGENASE HYCP" FT /function="INVOLVED IN HYDROGEN METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0085, (MTCY251.03), len: 220 aa. Possible hycP, FT hydrogenase (EC 1.-.-.-), integral membrane protein, weakly FT similar to P77524|HYFE_ECOLI HYDROGENASE-4 COMPONENT E from FT Escherichia coli (216 aa), FASTA scores: opt: 204, FT E():1.2e-07, (25.5% identity in 216 aa overlap)." FT /db_xref="GOA:P64681" FT /db_xref="UniProtKB/Swiss-Prot:P64681" FT /protein_id="CAA98921.1" FT /translation="MSNANFSILVDFAAGGLVLASVLIVWRRDLRAIVRLLAWQGAALA FT AIPLLRGIRDNDRALIAVGIAVLALRALVLPWLLARAVGAEAAAQREATPLVNTASSLL FT ITAGLTLTAFAITQPVVNLEPGVTINAVPAAFAVVLIALFVMTTRLHAVSQAAGFLMLD FT NGIAATAFLLTAGVPLIVELGASLDVLFAVIVIGVLTGRLRRIFGDADLDKLRELRD" FT CDS 93951..95417 FT /transl_table=11 FT /gene="hycQ" FT /locus_tag="Rv0086" FT /product="POSSIBLE HYDROGENASE HYCQ" FT /function="POSSIBLY INVOLVED IN HYDROGEN METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0086, (MTCY251.04), len: 488 aa. Possible hycQ, FT hydrogenase (EC 1.-.-.-), integral membrane protein, weakly FT similar to P77437|HYFF_ECOLI HYDROGENASE-4 COMPONENT F from FT Escherichia coli (526 aa), FASTA scores: opt: 948, E(): 0, FT (35.9% identity in 493 aa overlap); and FT AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B FT from Burkholderia pseudomallei (668 aa). Also similar to FT d9087711 & NUOL_ECOLI|P33607 NADH dehydrogenase I chain L FT from Escherichia coli (613 aa), FASTA scores: opt: 360, FT E():3.2e-13, (27.9% identity in 488 aa overlap); and to FT NUON_ECOLI|P33608 NADH dehydrogenase I chain N from FT Escherichia coli (425 aa), FASTA scores: opt: 375, E(): FT 3.9e-14, (25.0% identity in 432 aa overlap)." FT /db_xref="GOA:Q10883" FT /db_xref="InterPro:IPR003916" FT /db_xref="UniProtKB/TrEMBL:Q10883" FT /protein_id="CAA98922.1" FT /translation="MTGLLLAAILAPLAASIASLITGWRRTTATLTALSATTVLACAVA FT MGFWMGSGAQFGLGGLLRADALTVVMLVVIGIVGTLATAASIGYIDTELAHGHIDGRSA FT RLYGVLTPAFLCAMVLAVCANNIGVIWVAIEATTVITAFLVGHRRTRTALEATWKYVVI FT CSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLLIGYG FT AKAGLFPFHTWLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAYLRNGL FT LVVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLLHVLAHG FT IGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVGLIVLLGLPPFAMFASEL FT AIARSLANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPAITVPATAAAALM FT VGIVVSAALGITAGPLADLLGIAASNVGLP" FT CDS 95414..96892 FT /transl_table=11 FT /gene="hycE" FT /locus_tag="Rv0087" FT /standard_name="hevE" FT /product="POSSIBLE FORMATE HYDROGENASE HYCE (FHL)" FT /function="INVOLVED IN HYDROGEN METABOLISM; FHL PATHWAY." FT /EC_number="1.-.-.-" FT /note="Rv0087, (MTCY251.05), len: 492 aa. Possible hycE FT (alternate gene name: hevE), formate hydrogenlyase (EC FT 1.-.-.-), similar to others e.g. HYCE_ECOLI|P16431 formate FT hydrogenlyase subunit 5 from Escherichia coli (569 aa), FT FASTA scores: opt: 680, E(): 1.8e-38, (31.2% identity in FT 449 aa overlap); NP_457243.1|NC_003198 formate FT hydrogenlyase subunit 5 from Salmonella enterica subsp. FT enterica serovar Typhi (569 aa); NP_275541.1|NC_000916 FT formate hydrogenlyase subunit 5 from Methanothermobacter FT thermautotrophicus (370 aa); etc. Also some similarity with FT NUOD_ECOLI|P33600 NADH dehydrogenase I chain D from FT Escherichia coli (407 aa), FASTA scores: opt: 245, E(): FT 8.9e-10, (24.5% identity in 368 aa overlap). BELONGS TO THE FT COMPLEX I 49 kDa SUBUNIT FAMILY." FT /db_xref="GOA:Q10884" FT /db_xref="InterPro:IPR001268" FT /db_xref="UniProtKB/TrEMBL:Q10884" FT /protein_id="CAA98923.1" FT /translation="MMSASWLRHRVSERGLIATAEQLWADSFRLALVAAHDDGDSLRVV FT YLFLAGYPDRRVELEYVVPADNPEIRSLAYLSFPAGRFEREMADLYGIRPVGHPKPRRL FT VRHAHWPDWHPMRTDAGPAPEFTDTGAFPFLAVEGPGVYEIPVGPVHAGLIEPGHFRFS FT VAGETIVRLKARLWFVHRGIEKLFHGRPATAAVDLAERISGDTSAAHALAHSLAIEDAL FT GIELPHEVHRLRALIVELERLYNHAADLGALANDVGYSLANAHAQRIRENLLRRNAAVT FT GHRLLRGAIRAGGVALRALPDTDELAALAVDLAEVATLTLANSVVYDRFAGTAVLHPDD FT ASALGCLGYVARASGLRSDARVEHPTIVLPITEIGAPDGDVLARYTVRRDEFAASAALA FT QHIVESHTGPIEYAATLHPVGAPSSGIGIVEGWRGTIVHRVEIDVDGRITRAKVVDPSW FT FNWPALPVAMADTIVPDFPLANKSFNQSYAGNDL" FT CDS 96927..97601 FT /transl_table=11 FT /locus_tag="Rv0088" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0088, (MTCY251.06), len: 224 aa. Hypothetical FT unknown protein." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/Swiss-Prot:P0A5C3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98924.1" FT /translation="MSVYKHAPSRVRLRQTRSTVVKGRSGSLSWRRVRTGDLGLAVWGG FT REEYRAVKPGTPGIQPKGDMMTVTVVDAGPGRVSRSVEVAAPAAELFAIVADPRRHREL FT DGSGTVRGNIKVPAKLVVGSKFSTKMKLFGLPYRITSRVTALKPNELVEWSHPLGHRWR FT WEFESLSPTLTRVTETFDYHAAGAIKNGLKFYEMTGFAKSNAAGIEATLAKLSDQYARG FT RA" FT CDS 97758..98351 FT /transl_table=11 FT /locus_tag="Rv0089" FT /product="POSSIBLE METHYLTRANSFERASE/METHYLASE" FT /function="THOUGHT TO CAUSE METHYLATION." FT /EC_number="2.1.1.-" FT /note="Rv0089, (MTCY251.07), len: 197 aa. Possible FT methyltransferase (EC 2.1.1.-), showing some weak FT similarity to others e.g. NP_299749.1|NC_002488 FT 3-demethylubiquinone-9 3-methyltransferase from Xylella FT fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative FT methyltransferase from Streptomyces coelicolor (285 aa); FT NP_111415.1|NC_002689 Predicted SAM-dependent FT methyltransferase from Thermoplasma volcanium (245 aa); FT etc. Also some similarity with many biotin biosynthesis FT proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS FT PROTEIN from Escherichia coli (251 aa), FASTA scores: opt: FT 202, E(): 4.5e-07, (39.0% identity in 118 aa overlap); etc. FT BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY." FT /db_xref="GOA:P65346" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P65346" FT /protein_id="CAA98925.1" FT /translation="MDQPWNANIHYDALLDAMVPLGTQCVLDVGCGDGLLAARLARRIP FT YVTAVDIDAPVLRRAQTRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIEDTRTA FT LSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHSAPIKWPPPQ FT TLHELRSHVRALLPGACIRRLLYGRVLVTWRAPV" FT CDS 98480..99250 FT /transl_table=11 FT /locus_tag="Rv0090" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0090, (MTCY251.08), len: 256 aa. Possible membrane FT protein." FT /db_xref="GOA:P64683" FT /db_xref="InterPro:IPR014511" FT /db_xref="UniProtKB/Swiss-Prot:P64683" FT /protein_id="CAA98926.1" FT /translation="MAKNQNRIRNRWELITCGLGGHVTYAPDDAALAARLRASTGLGEV FT WRCLRCGDFALGGPQGRGAPEDAPLIMRGKALRQAIIIRALGVERLVRALVLALAAWAV FT WEFRGARGAIQATLDRDLPVLRAAGFKVDQMTVIHALEKALAAKPSTLALITGMLAAYA FT VLQAVEGVGLWLLKRWGEYFAVVATSIFLPLEVHDLAKGITTTRVVTFSINVAAVVYLL FT ISKRLFGVRGGRKAYDVERRGEQLLDLERAAMLT" FT CDS 99684..100451 FT /transl_table=11 FT /gene="mtn" FT /locus_tag="Rv0091" FT /standard_name="pfs" FT /product="PROBABLE BIFUNCTIONAL MTA/SAH NUCLEOSIDASE MTN: FT 5'-METHYLTHIOADENOSINE NUCLEOSIDASE (METHYLTHIOADENOSINE FT METHYLTHIORIBOHYDROLASE) + S-ADENOSYLHOMOCYSTEINE FT NUCLEOSIDASE (S-ADENOSYL-L-HOMOCYSTEINE FT HOMOCYSTEINYLRIBOHYDROLASE)" FT /function="RESPONSIBLE FOR CLEAVAGE OF THE GLYCOSIDIC BOND FT IN BOTH 5'-METHYLTHIOADENOSINE (MTA) AND FT S-ADENOSYLHOMOCYSTEINE (SAH) [CATALYTIC ACTIVITY 1: FT Methylthioadenosine + H2O = adenine + FT 5-methylthio-D-ribose] [CATALYTIC ACTIVITY 2: FT S-adenosyl-L-homocysteine + H2O = adenine + FT S-D-ribosyl-L-homocysteine]." FT /EC_number="3.2.2.16" FT /EC_number="3.2.2.9" FT /note="Rv0091, (MTCY251.10), len: 255 aa. Probable mtn FT (alternate gene name: pfs), FT methylthioadenosine/S-Adenosylhomocysteine nucleosidase FT (MTA/SAH nucleosidase), including 5'-methylthioadenosine FT nucleosidase (EC 3.2.2.16) and S-adenosylhomocysteine FT nucleosidase (EC 3.2.2.9), similar to others e.g. FT NP_521493.1|NC_003295 PROBABLE BIFUNCTIONAL PROTEIN FT (MTA/SAH NUCLEOSIDASE) (P46): 5'-METHYLTHIOADENOSINE FT NUCLEOSIDASE AND S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE from FT Ralstonia solanacearum (261 aa); AAC45731.1|U55214 Pfs from FT Treponema pallidum (249 aa); P96122|MTN_TREPA MTA/SAH FT NUCLEOSIDASE from Treponema pallidum (269 aa); FT PFS_ECOLI|P24247 pfs protein (p46) from Escherichia coli FT (232 aa), FASTA scores: opt: 214, E(): 3.8e-08, (30.5% FT identity in 246 aa overlap); etc. BELONGS TO THE MTN FT FAMILY." FT /db_xref="GOA:P67656" FT /db_xref="HSSP:1JYS" FT /db_xref="InterPro:IPR018017" FT /db_xref="UniProtKB/Swiss-Prot:P67656" FT /protein_id="CAA98927.1" FT /translation="MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRV FT VLAAAGMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQHDFGL FT LTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAPLSTAAGGGGRQPR FT IYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDIPWLVIRALSDLA FT GADSGVDFNRFVGEVAASSARVLLRLLPVLTAC" FT CDS 100583..102868 FT /transl_table=11 FT /gene="ctpA" FT /locus_tag="Rv0092" FT /product="PROBABLE CATION TRANSPORTER P-TYPE ATPASE A CTPA" FT /function="CATION-TRANSPORTING ATPASE; POSSIBLY CATALYZES FT THE TRANSPORT OF A CATION (POSSIBLY COPPER) WITH THE FT HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT CATION(IN) = ADP + PHOSPHATE + CATION(OUT)]." FT /EC_number="3.6.3.-" FT /note="Rv0092, (MTCY251.11), len: 761 aa. Probable ctpA, FT cation-transporting P-type ATPase A (transmembrane protein) FT (EC 3.6.3.-), highly similar to others e.g. FT CTPA_MYCLE|P46839 cation-transporting P-type ATPase A from FT Mycobacterium leprae (780 aa), FASTA scores: opt: 3454, FT E(): 0, (74.4% identity in 741 aa overlap); FT CAB66270.1|AL136519 probable cation-transporting P-type FT ATPase from Streptomyces coelicolor (760 aa); FT NP_391230.1|NC_000964 protein similar to heavy FT metal-transporting ATPase from Bacillus subtilis (803 aa); FT etc. Also highly similar to MTCY251.22c from Mycobacterium FT tuberculosis, FASTA score: (68.3% identity in 742 aa FT overlap). Contains PS01047 Heavy-metal-associated domain, FT and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO FT THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), FT SUBFAMILY IB." FT /db_xref="GOA:Q10876" FT /db_xref="HSSP:1MWY" FT /db_xref="InterPro:IPR006121" FT /db_xref="UniProtKB/Swiss-Prot:Q10876" FT /protein_id="CAA98928.1" FT /translation="MTTAVTGEHHASVQRIQLRISGMSCSACAHRVESTLNKLPGVRAA FT VNFGTRVATIDTSEAVDAAALCQAVRRAGYQADLCTDDGRSASDPDADHARQLLIRLAI FT AAVLFVPVADLSVMFGVVPATRFTGWQWVLSALALPVVTWAAWPFHRVAMRNARHHAAS FT METLISVGITAATIWSLYTVFGNHSPIERSGIWQALLGSDAIYFEVAAGVTVFVLVGRY FT FEARAKSQAGSALRALAALSAKEVAVLLPDGSEMVIPADELKEQQRFVVRPGQIVAADG FT LAVDGSAAVDMSAMTGEAKPTRVRPGGQVIGGTTVLDGRLIVEAAAVGADTQFAGMVRL FT VEQAQAQKADAQRLADRISSVFVPAVLVIAALTAAGWLIAGGQPDRAVSAALAVLVIAC FT PCALGLATPTAMMVASGRGAQLGIFLKGYKSLEATRAVDTVVFDKTGTLTTGRLQVSAV FT TAAPGWEADQVLALAATVEAASEHSVALAIAAATTRRDAVTDFRAIPGRGVSGTVSGRA FT VRVGKPSWIGSSSCHPNMRAARRHAESLGETAVFVEVDGEPCGVIAVADAVKDSARDAV FT AALADRGLRTMLLTGDNPESAAAVATRVGIDEVIADILPEGKVDVIEQLRDRGHVVAMV FT GDGINDGPALARADLGMAIGRGTDVAIGAADIILVRDHLDVVPLALDLARATMRTVKLN FT MVWAFGYNIAAIPVAAAGLLNPLVAGAAMAFSSFFVVSNSLRLRKFGRYPLGCGTVGGP FT QMTAPSSA" FT misc_feature 100640..100726 FT /note="PS01047 Heavy-metal-associated domain" FT misc_feature 101909..101929 FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT CDS complement(102815..103663) FT /transl_table=11 FT /locus_tag="Rv0093c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0093c, (MTCY251.12c), len: 282 aa. Probable FT conserved membrane protein, equivalent only to FT CAC30943.1|AL583924 probable integral membrane protein from FT Mycobacterium leprae (237 aa)." FT /db_xref="GOA:Q10890" FT /db_xref="UniProtKB/Swiss-Prot:Q10890" FT /protein_id="CAA98929.1" FT /translation="MLAQATTAGSFNHHASTVLQGCRGVPAAMWSEPAGAIRRHCATID FT GMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAESRP FT VVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPTGAG FT THLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAVSTTR FT ILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWPTDGSA FT A" FT CDS complement(103710..104663) FT /transl_table=11 FT /locus_tag="Rv0094c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0094c, (MTCY251.13c), len: 317 aa. Member of 13E12 FT repeat family, showing some similarity to U15187|MLU15187_7 FT from Mycobacterium leprae (94 aa), FASTA score: (49.4% FT identity in 79 aa overlap)." FT /db_xref="InterPro:IPR003870" FT /db_xref="UniProtKB/TrEMBL:Q50655" FT /protein_id="CAA98930.1" FT /translation="MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTER FT ARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTPDA FT AAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGKGFT FT GGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFAN FT DRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGH FT TEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDKPD" FT repeat_region complement(103713..105215) FT /label=REP-2 FT /rpt_type=DIRECT FT /note="REP-2, len: 1503 bp. REP251, member of REP13E12 FT family." FT CDS complement(104805..105215) FT /transl_table=11 FT /locus_tag="Rv0095c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0095c, (MTCY251.14c), len: 136 aa. Member of 13E12 FT repeat, also partially similar to AF0418|AF041819_8 from FT Mycobacterium bovis BCG (222 aa), FASTA score: (89.6% FT identity in 96 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:Q10891" FT /protein_id="CAA98931.1" FT /translation="MRYLPVSTRRIWVNPLCHFSFTVISGALFVSARRYDSNMLANSRE FT ELVEVFDALDADLDRLDEVSFEVLSTPERLRSLERLECLARRLPAAQHTLINQLDTQAS FT EEELGGTLCCALANRLRITKPEAGRRSAEAKP" FT CDS 105324..106715 FT /transl_table=11 FT /gene="PPE1" FT /locus_tag="Rv0096" FT /product="PPE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0096, (MTCY251.15), len: 463 aa. Member of the FT Mycobacterium tuberculosis PPE family, similar to many e.g. FT Z46257|MLACEA_3 aceA gene for isocitrate L from FT Mycobacterium leprae (438 aa), FASTA scores: opt: 1207, FT E(): 0, (55.3% identity in 380 aa overlap). Also similar to FT Z97559|MTCY261_19 from Mycobacterium tuberculosis (473 aa), FT FASTA score: (40.2% identity in 478 aa overlap); FT YHS6_MYCTU|P42611 hypothetical 50.6 kDa protein (517 aa), FT FASTA scores: opt: 365, E(): 4.6e-12, (37.6% identity in FT 178 aa overlap). Also similar to MTCY274.23c from FT Mycobacterium tuberculosis, FASTA score: (31.1% identity in FT 383 overlap). Some similarity also to MTCY31.06c and FT MTCY48.17 and other mycobacterial PPE family proteins." FT /db_xref="GOA:Q10892" FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q10892" FT /protein_id="CAE55240.1" FT /translation="MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQL FT LGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMPTP FT AELAANHAIHGVLIATNFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATVAVP FT STQPAPPIRAPGGDAADTRLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSPAVTV FT VLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLLPIAAA FT LGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLA FT PPGVSSGPKAGTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRDEFLDATA FT TVDAATDVPAPANAAGSQGAGTLGFAGTAPTTSGAAAGMVQLSSHSTSTTVPLLPTTWT FT TDAEQ" FT CDS 106734..107603 FT /transl_table=11 FT /locus_tag="Rv0097" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0097, (MTCY251.16), len: 289 aa. Possible FT oxidoreductase (EC 1.-.-.-), equivalent to FT NP_302343.1|NC_002677 putative oxidoreductase from FT Mycobacterium leprae (289 aa). Also highly similar to FT BAB69377.1|AB070955 putative oxidoreductase from FT Streptomyces avermitilis (296 aa); and weakly similar to FT others e.g. NP_518867.1|NC_003295 PUTATIVE FT ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE FT OXIDOREDUCTASE PROTEIN from Ralstonia solanacearum (301 FT aa); NP_286110.1|NC_002655 taurine dioxygenase FT (2-oxoglutarate-dependent) from Escherichia coli strain FT O157:H7 (283 aa); NP_252624.1|NC_002516 taurine dioxygenase FT from Pseudomonas aeruginosa (277 aa); ECAE00014310 (283 FT aa), FASTA scores: opt: 304, E(): 2.6e-13, (27.8% identity FT in 288 aa overlap); TFDA_ALCEU|P10088 FT 2,4-dichlorophenoxyacetate monooxygenase from A. eutropha FT (287 aa), FASTA scores: opt: 188, E(): 3.5e-06, (26.6% FT identity in 188 aa overlap); etc. Contains PS00077 FT Cytochrome c oxidase subunit I, copper B binding region FT signature." FT /db_xref="GOA:P67755" FT /db_xref="HSSP:1GY9" FT /db_xref="InterPro:IPR003819" FT /db_xref="UniProtKB/Swiss-Prot:P67755" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA98933.1" FT /translation="MTLKVKGEGLGAQVTGVDPKNLDDITTDEIRDIVYTNKLVVLKDV FT HPSPREFIKLGRIIGQIVPYYEPMYHHEDHPEIFVSSTEEGQGVPKTGAFWHIDYMFMP FT EPFAFSMVLPLAVPGHDRGTYFIDLARVWQSLPAAKRDPARGTVSTHDPRRHIKIRPSD FT VYRPIGEVWDEINRTTPPIKWPTVIRHPKTGQEILYICATGTTKIEDKDGNPVDPEVLQ FT ELMAATGQLDPEYQSPFIHTQHYQVGDIILWDNRVLMHRAKHGSAAGTLTTYRLTMLDG FT LKTPGYAA" FT misc_feature 107474..107488 FT /note="PS00077 Cytochrome c oxidase subunit I, copper B FT binding region signature" FT CDS 107600..108151 FT /transl_table=11 FT /locus_tag="Rv0098" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0098, (MTCY251.17), len: 183 aa. Conserved FT hypothetical protein, equivalent to CAC30948.1|AL583924 FT conserved hypothetical protein from Mycobacterium leprae FT (183 aa). Also some similarity with BAB69378.1|AB070955 FT hypothetical protein from Streptomyces avermitilis (172 FT aa)." FT /db_xref="PDB:2PFC" FT /db_xref="UniProtKB/Swiss-Prot:P64685" FT /protein_id="CAA98934.1" FT /translation="MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDAQ FT YSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRG FT WSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEF FT WDENGGAASGEIELAALNIP" FT CDS 108156..109778 FT /transl_table=11 FT /gene="fadD10" FT /locus_tag="Rv0099" FT /product="POSSIBLE FATTY-ACID-CoA LIGASE FADD10 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv0099, (MTCY251.18), len: 540 aa. Possible fadD10, FT fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to FT MLACEA_4|Q50176 LONG CHAIN FATTY ACID-CoA LIGASE from FT Mycobacterium leprae (532 aa), FASTA scores: opt: 2580, FT E(): 0, (74.6% identity in 531 aa overlap). Also similar to FT many e.g. BAB69379.1|AB070955 long-chain fatty acid--CoA FT ligase from Streptomyces avermitilis (518 aa); FT NP_419782.1|NC_002696 putativ long-chain-fatty-acid--CoA FT ligase from Caulobacter crescentus (530 aa); FT NP_435326.1|NC_003037 probable long chain fatty acid CoA FT ligase from Sinorhizobium meliloti (508 aa); etc. Also FT similar to ACSA_BACSU|P39062 acetyl-coenzyme A synthetase FT from Bacillus subtilis (572 aa), FASTA scores: opt: 415, FT E(): 9.8e-20, (27.1% identity in 539 aa overlap). Contains FT PS00455 putative AMP-binding domain signature. BELONGS TO FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:Q10878" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q10878" FT /protein_id="CAA98935.1" FT /translation="MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYR FT ELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAA FT IERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGN FT ADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLP FT ATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSA FT NATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIE FT AGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVL FT IDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEI FT PDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQS FT GKVMRASLAAAATADKARVVVRG" FT misc_feature 108675..108710 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS 109783..110019 FT /transl_table=11 FT /locus_tag="Rv0100" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0100, (MTCY251.19), len: 78 aa. Conserved FT hypothetical protein, equivalent only to FT CAC30950.1|AL583924 conserved hypothetical protein from FT Mycobacterium leprae (78 aa)." FT /db_xref="GOA:P64687" FT /db_xref="InterPro:IPR006162" FT /db_xref="UniProtKB/Swiss-Prot:P64687" FT /protein_id="CAA98936.1" FT /translation="MRDRILAAVCDVLYIDEADLIDGDETDLRDLGLDSVRFVLLMKQL FT GVNRQSELPSRLAANPSIAGWLRELEAVCTEFG" FT CDS 110001..117539 FT /transl_table=11 FT /gene="nrp" FT /locus_tag="Rv0101" FT /product="PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE FT SYNTHASE)" FT /function="INVOLVED IN LIPID METABOLISM." FT /EC_number="6.-.-.-" FT /note="Rv0101, (MTCY251.20), len: 2512 aa. Probable nrp, FT peptide synthetase (EC 6.-.-.-), similar to others e.g. FT AAD44234.1|AF143772_40|PstB peptide synthetase from FT Mycobacterium avium (2552 aa); 7476034|S77657 cyclic FT peptide synthetase from Mycobacterium leprae (1401 aa), FT FASTA scores: opt: 4268, E(): 0, (65.7% identity in 1091 aa FT overlap); part of CAB55600.1|AJ238027 peptide synthetase FT from Mycobacterium smegmatis (5990). Also similar to e.g. FT AAD56240.1|AF184977_1|AF184977 DhbF protein from Bacillus FT subtilis (2378 aa); SRF1_BACSU|P27206 surfactin synthetase FT subunit 1 (3587 aa), FASTA scores: opt: 1708, E(): 0, FT (30.6% identity in 1633 aa overlap): etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), 2 x PS00455 Putative FT AMP-binding domain signature, and PS00012 FT Phosphopantetheine attachment site. BELONGS TO THE FT ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. THOUGHT TO BE NOT FT INVOLVED IN MYCOBACTIN BIOSYNTHESIS (see citation below)." FT /db_xref="GOA:Q10896" FT /db_xref="HSSP:1DNY" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q10896" FT /protein_id="CAA98937.1" FT /translation="MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRLELARFLAA FT LHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADEHLQSTWCSGILGKPLVR FT HTVHTDPNGYVTGLDVHTHHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLRE FT AHRRETAKVEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNA FT FDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVATCLVN FT SVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVEALTLNF FT IREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWNRADLPACKTHPK FT VAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQGDWPARQPSTPAWFLDSARGV FT HQFLGRRRFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDTAD FT EISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTAY FT IMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTSDISVEEIFGGA FT ACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADGDAIDAIGRSRLRQ FT IVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIVCDQTTMDGALLRL FT GRPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDA FT EGFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTRE FT GEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQWSAAGLNTAE FT TGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILPETRRYLGWRLSLLDLIGA FT DTAANLADYAPTPDAPTGEDRFRPLVAAQRPAAIPLSFAQRRLWFLDQLQRPAPVYNMA FT VALRLRGYLDTEALGAAVADVVGRHESLRTVFPAVDGVPRQLVIEARRADLGCDIVDAT FT AWPADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEHVLVAVAHHIAADGWSVAPLT FT ADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAG FT MPERLRLPTARPYPPVADQRGASLVVDWPASVQQQVRRIARQHNATSFMVVAAGLAVLL FT SKLSGSPDVAVGFPIAGRSDPALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVRARSLA FT AYENQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTA FT RMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPERTV FT SSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARIPEAEAVCCGDASMTY FT RELDEASNRLAHRLAGCGAGPGECVALLFERCAPAVVAMVAVLKTGAAYLPIDPANPPP FT RVAFMLGDAVPVAAVTTAGLRSRLAGHDLPIIDVVDALAAYPGTPPPMPAAVNLAYILY FT TSGTTGEPKGVGITHRNVTRLFASLPARLSAAQVWSQCHSYGFDASAWEIWGALLGGGR FT LVIVPESVAASPNDFHGLLVAEHVSVLTQTPAAVAMLPTQGLESVALVVAGEACPAALV FT DRWAPGRVMLNAYGPTETTICAAISAPLRPGSGMPPIGVPVSGAALFVLDSWLRPVPAG FT VAGELYIAGAGVGVGYWRRAGLTASRFVACPFGGSGARMYRTGDLVCWRADGQLEFLGR FT TDDQVKIRGYRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPA FT GLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGDTNGYRAPAGPVEKT FT VAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAAINTTLNADLPVRALLHASSTRGL FT SQLLGRDARPTSDPRLVSVHGDNPTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTV FT LLTGATGFLGRYLVLELLRRLDVDGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFK FT ELAADRLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPNVAGT FT AELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGYGTSK FT WAGEVLLREANDLCALPVAVFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPRSF FT YEPDSEGNRQRAHFDGLPVTFVAEAIAVLGARVAGSSLAGFATYHVMNPHDDGIGLDEY FT VDWLIEAGYPIRRIDDFAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQRLQPLKPTR FT GCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL" FT misc_feature 110070..110093 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 111729..111764 FT /note="PS00455 Putative AMP-binding domain signature" FT misc_feature 114906..114941 FT /note="PS00455 Putative AMP-binding domain signature" FT misc_feature 116040..116087 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS 117714..119699 FT /transl_table=11 FT /locus_tag="Rv0102" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0102, (MTCY251.21), len: 661 aa. Probable FT conserved integral membrane protein, highly similar to FT P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible FT membrane protein from Mycobacterium leprae (659 aa), FASTA FT scores: opt: 3107, E(): 0, (70.2% identity in 662 aa FT overlap). Also similar to others e.g. CAC01497.1|AL391017 FT putative integral membrane protein from Streptomyces FT coelicolor (316 aa); etc. Contains PS00343 Gram-positive FT cocci surface proteins 'anchoring' hexapeptide." FT /db_xref="GOA:P64689" FT /db_xref="InterPro:IPR019108" FT /db_xref="UniProtKB/Swiss-Prot:P64689" FT /protein_id="CAA98938.1" FT /translation="MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLVS FT GARRYAEAGNPYPGAFVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAAAF FT RIHLLAERVSGLWLGLAATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWIVAA FT ICALVVATALRLYTRWLGHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVFAVAF FT ATLTGLKIAAALAGTTPSRAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFARLGLL FT AGVILTSVWLFDCWRLLVRPPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAPRFLTHA FT FTAWDVFLGYELPQPPTIARVLTVWRFDSLIGAAGVVLAIGYAAGFAALRRRGNSWPVG FT RLIAWLTGCAALVFTSGSGVRAYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRVL FT PVTGDGRPPGAREWLTWLLHSRVTTFLSHPITAFVLFVASPYIVYFTPLFDTFVRYHWG FT HEFMAIHFLVVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFGIALMTMSSTV FT GATFYRSVNLPWLSSIIADQHLGGGIAWSLTELPVIMVIVALVTQWARQDRRVASREDR FT HADSDYADDELEAYNAMLRELSRMRR" FT misc_feature 119085..119102 FT /note="PS00343 Gram-positive cocci surface proteins FT 'anchoring' hexapeptide" FT CDS complement(119915..122173) FT /transl_table=11 FT /gene="ctpB" FT /locus_tag="Rv0103c" FT /product="PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB" FT /function="CATION-TRANSPORTING ATPASE; POSSIBLY CATALYZES FT THE TRANSPORT OF A CATION (POSSIBLY COOPPER) WITH THE FT HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT CATION(IN) = ADP + ORTHOPHOSPHATE + CATION(OUT)]." FT /EC_number="3.6.3.-" FT /note="Rv0103c, (MTCY251.22c), len: 752 aa. Probable ctpB, FT cation-transporting P-type ATPase B (transmembrane protein) FT (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840 FT cation-transporting P-type ATPase B from Mycobacterium FT leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5% FT identity in 752 aa overlap). Also highly similar to others FT e.g. CAB96031.1|AL360055 putative metal transporter ATPase FT from Streptomyces coelicolor (753 aa); FT NP_241423.1|NC_002570 copper-transporting ATPase from FT Bacillus halodurans (806 aa); etc. Also highly similar to FT Z46257|MLACEA_7 aceA gene for isocitrate L from FT Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, FT E():0, (76.5% identity in 752 aa overlap). And similar to FT MTCY251.11 from Mycobacterium tuberculosis, FASTA score: FT (68.3% identity in 742 aa overlap). Contains PS01047 FT Heavy-metal-associated domain, PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB." FT /db_xref="GOA:Q10877" FT /db_xref="HSSP:1JWW" FT /db_xref="InterPro:IPR006121" FT /db_xref="UniProtKB/Swiss-Prot:Q10877" FT /protein_id="CAA98939.1" FT /translation="MAAPVVGDADLQSVRRIRLDVLGMSCAACASRVETKLNKIPGVRA FT SVNFATRVATIDAVGMAADELCGVVEKAGYHAAPHTETTVLDKRTKDPDGAHARRLLRR FT LLVAAVLFVPLADLSTLFAIVPSARVPGWGYILTALAAPVVTWAAWPFHSVALRNARHR FT TTSMETLISVGIVAATAWSLSSVFGDQPPREGSGIWRAILNSDSIYLEVAAGVTVFVLA FT GRYFEARAKSKAGSALRALAELGAKNVAVLLPDGAELVIPASELKKRQRFVTRPGETIA FT ADGVVVDGSAAIDMSAMTGEAKPVRAYPAASVVGGTVVMDGRLVIEATAVGADTQFAAM FT VRLVEQAQTQKARAQRLADHIAGVFVPVVFVIAGLAGAAWLVSGAGADRAFSVTLGVLV FT IACPCALGLATPTAMMVASGRGAQLGIFIKGYRALETIRSIDTVVFDKTGTLTVGQLAV FT STVTMAGSGTSERDREEVLGLAAAVESASEHAMAAAIVAASPDPGPVNGFVAVAGCGVS FT GEVGGHHVEVGKPSWITRTTPCHDAALVSARLDGESRGETVVFVSVDGVVRAALTIADT FT LKDSAAAAVAALRSRGLRTILLTGDNRAAADAVAAQVGIDSAVADMLPEGKVDVIQRLR FT EEGHTVAMVGDGINDGPALVGADLGLAIGRGTDVALGAADIILVRDDLNTVPQALDLAR FT ATMRTIRMNMIWAFGYNVAAIPIAAAGLLNPLIAGAAMAFSSFFVVSNSLRLRNFGAQ" FT misc_feature complement(120818..120838) FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT misc_feature complement(122027..122113) FT /note="PS01047 Heavy-metal-associated domain" FT CDS 122317..123831 FT /transl_table=11 FT /locus_tag="Rv0104" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0104, (MTCY251.23), len: 504 aa. Conserved FT hypothetical protein, showing weak similarity with other FT cAMP-dependent protein kinases e.g. AAC37564.1|M65066 FT cAMP-dependent protein kinase RI-beta regulatory subunit FT from Homo sapiens (380 aa); etc ." FT /db_xref="GOA:Q10898" FT /db_xref="HSSP:1BPK" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/Swiss-Prot:Q10898" FT /protein_id="CAA98917.1" FT /translation="MTPVTTFPLVDAILAGRDRNLDGVILIAAQHLLQTTHAMLRSLFR FT VGLDPRNVAVIGKCYSTHPGVVDAMRADGIYVDDCSDAYAPHESFDTQYTRHVERFFAE FT SWARLTAGRTARVVLLDDGGSLLAVAGAMLDASADVIGIEQTSAGYAKIVGCALGFPVI FT NIARSSAKLLYESPIIAARVTQTAFERTAGIDSSAAILITGAGAIGTALADVLRPLHDR FT VDVYDTRSGCMTPIDLPNAIGGYDVIIGATGATSVPASMHELLRPGVLLMSASSSDREF FT DAVALRRRTTPNPDCHADLRVADGSVDATLLNSGFPVNFDGSPMCGDASMALTMALLAA FT AVLYASVAVADEMSSDHPHLGLIDQGDIVASFLNIDVPLQALSRLPLLSIDGYRRLQVR FT SGYTLFRQGERADHFFVIESGELEALVDGKVILRLGAGDHFGEACLLGGMRRIATVRAC FT EPSVLWELDGKAFGDALHGDAAMREIAYGVARTRLMHAGASESLMV" FT CDS complement(123980..124264) FT /transl_table=11 FT /gene="rpmB1" FT /locus_tag="Rv0105c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L28-1 RPMB1" FT /function="POSSIBLY INVOLVED IN A TRANSLATION MECHANISM." FT /note="Rv0105c, (MTCY251.24c), len: 94 aa. Probable rpmB1, FT 50S ribosomal protein L28-1, highly similar to others e.g. FT Q9X8K8|R28B_STRCO 50S RIBOSOMAL PROTEIN L28-2 from FT Streptomyces coelicolor (78 aa); RL28_ECOLI|P02428 50s FT ribosomal protein l28 from Escherichia coli (77 aa), FASTA FT scores: opt: 167, E(): 6.2e-06, (40.7% identity in 59 aa FT overlap); etc. Also similar to MTCY63A_2 from Mycobacterium FT tuberculosis. BELONGS TO THE L28P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P0A5V6" FT /db_xref="InterPro:IPR001383" FT /db_xref="UniProtKB/Swiss-Prot:P0A5V6" FT /protein_id="CAE55241.1" FT /translation="MSARCQITGRTVGFGKAVSHSHRRTRRRWPPNIQLKAYYLPSEDR FT RIKVRVSAQGIKVIDRDGHRGRRRAARAGSAPAHFARQAGSSLRTAAIL" FT CDS 124374..125570 FT /transl_table=11 FT /locus_tag="Rv0106" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0106, (MTCY251.25), len: 398 aa. Conserved FT hypothetical protein, similar to others e.g. FT AL049841|SCE9_33 from Streptomyces coelicolor (370 aa), FT FASTA scores: opt: 282, E(): 2.5e-11, (32.0% identity in FT 381 aa overlap); etc. Some similarity to P94400 HOMOLOGUE FT TO NITRILE HYDRATASE REGION from Bacillus subtilis (397 FT aa), FASTA scores: opt: 226, E(): 5.4e-08, (26.4% identity FT in 405 aa overlap). Also similar to COBW_PSEDE|P29937 FASTA FT score: (25.3% identity in 186 aa overlap); and FT P47K_PSECL|P31521 47 kDa protein (p47k) (419 aa), FASTA FT score: (25.9% identity in 401 aa overlap)." FT /db_xref="InterPro:IPR011629" FT /db_xref="UniProtKB/Swiss-Prot:P64691" FT /protein_id="CAA98919.1" FT /translation="MRTPVILVAGQDHTDEVTGALLRRTGTVVVEHRFDGHVVRRMTAT FT LSRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAPWLEPQPICW FT AIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSLGEDELPDGRTVAQVTVGQ FT AEFADLLVLTHPEPVAVAVLRRLAPRARITGGVDRVELALAHLDDNSRRGRTDTPHTPL FT LAGLPPLAADGEVAIVEFSARRPFHPQRLHAAVDLLLDGVVRTRGRLWLANRPDQVMWL FT ESAGGGLRVASAGKWLAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVLVCGADP FT TDIVNALNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAGEFSAHRNSGESR" FT CDS complement(125643..130541) FT /transl_table=11 FT /gene="ctpI" FT /locus_tag="Rv0107c" FT /product="PROBABLE CATION-TRANSPORTER ATPASE I CTPI" FT /function="CATION-TRANSPORTING ATPASE; POSSIBLY CATALYZES FT THE TRANSPORT OF A CATION (POSSIBLY MAGNESIUM) WITH THE FT HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + FT CATION(IN) = ADP + PHOSPHATE + CATION(OUT)]." FT /EC_number="3.6.3.-" FT /note="Rv0107c, (MTCY251.26c, MTV031.01c), len: 1632 aa. FT Probable ctpI, cation-transporting ATPase I P-type (EC FT 3.6.3.-), highly similar to NP_302704.1|NC_002677 probable FT cation transport ATPase from Mycobacterium leprae (1609 FT aa); and similar to others e.g. CAB69720.1|AL137166 FT putative transport ATPase from Streptomyces coelicolor FT (1472 aa); ATA1_SYNY|P37367 cation-transporting ATPase pma1 FT from Synechocystis sp. (915 aa), FASTA scores: opt: 603, FT E(): 6.6e-29, (32.4% identity in 710 aa overlap); etc. Also FT similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium FT tuberculosis, FASTA score: (34.4% identity in 796 aa FT overlap). Contains PS00154 E1-E2 ATPases phosphorylation FT site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 FT ATPASES)." FT /db_xref="GOA:Q10900" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:Q10900" FT /protein_id="CAA98940.1" FT /translation="MKIPGVATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLEL FT TGPVVQSVVQTTGRAIGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPFPRWHEHAA FT MVEEPVRRIPGVAEAHVEGSLGRLVVELEPDADSDIAVDEVRDVVSAVAADIFLAGSVS FT SPNSAPFADPGNPLAILVPLTAAAMDLVAMGATVTGWVARLPAAPQTTRALAALINHQP FT RMVSLMESRLGRVGTDIALAATTAAANGLTQSLGTPLLDLVQRSLQISEAAAHRRVWRD FT REPALASPRRPQAPVVPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAAIDTAKG FT SRAGPVEQYVNQAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAVLGR FT GLANTGQLVLDPGALRRLDRVRVVVIDGAALRGDNRAVLHAQGDEPGWDDDRVYEVADA FT LLHGEQAPEPDPDELPATGARLRWAPAQGPSATPAQGLEHADLVVDGQCVGSVDVGWEV FT DPYAIPLLQTAHRTGARVVLRHVAGTEDLSASVGSTHPPGTPLLKLVRELRADRGPVLL FT ITAVHRDFASTDTLAALAIADVGVALDDPRGATPWTADLITGTDLAAAVRILSALPVAR FT AASESAVHLAQGGTTLAGLLLVTGEQDKTTNPASFRRWLNPVNAAAATALVSGMWSAAK FT VLRMPDPTPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRILDDLSYEPVMAPL FT RGPARTLAQLAVATRHELADPLTPILAVGAAASAIVGSNIDALLVAGVMTVNAITGGVQ FT RLRAEAAAAELFAEQDQLVRRVVVPAVATTRRRLEAARHATRTATVSAKSLRVGDVIDL FT AAPEVVPADARLLVAEDLEVDESFLTGESLPVDKQVDPVAVNDPDRASMLFEGSTIVAG FT HARAIVVATGVGTAAHRAISAVADVETAAGVQARLRELTSKVLPMTLAGGAAVTALALL FT RRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTARGALVRSPRTIEALGRVD FT TICFDKTGTLTENRLRVVCALPSSTAAERDPLPQTTDAPSAEVLRAAARASTQPHNGEG FT HAHATDEAILAAASALAGSLSSQGDSEWVVLAEVPFESSRGYAAAIGRVGTDGIPMLML FT KGAPETILPRCRLADPGVDHEHAESVVRHLAEQGLRVLAVAQRTWDNGTTHDDETDADA FT VDAVAHDLELIGYVGLADTARSSSRPLIEALLDAERNVVLITGDHPITARAIARQLGLP FT ADARVVTGAELAVLDEEAHAKLAADMQVFARVSPEQKVQIVAALQRCGRVTAMVGDGAN FT DAAAIRMADVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTIL FT VGGNVGEVLFTVIGTAFGAGRAPVGTRQLLLVNLLTDMFPALAVAVTSQFAEPDDAEYP FT TDDAAERAQREHRRAVLIGPTPSLDAPLLRQIVNRGVVTAAGATAAWAIGRWTPGTERR FT TATMGLTALVMTQLAQTLLTRRHSPLVIATALGSAGVLVGIIQTPVISHFSGVPRWDRS FT PGRASSAPRQEPPQSQRWHRSGWQAQSVSCNLMNALTTRKTLTRVDRTYRRPR" FT misc_feature complement(127365..127385) FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT CDS complement(130895..131104) FT /transl_table=11 FT /locus_tag="Rv0108c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0108c, (MTV031.02c), len: 69 aa. Hypothetical FT unknown protein. TBparse score is 0.890." FT /db_xref="UniProtKB/TrEMBL:O53630" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17302.1" FT /translation="MVPVETLHSGDPITDVNGGGQRYIVLESKTVGDSCVVLELESRVN FT HQLQVIEKSFPAGYHVGRAHHRIL" FT CDS 131382..132872 FT /transl_table=11 FT /gene="PE_PGRS1" FT /locus_tag="Rv0109" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0109, (MTV031.03c), len: 496 aa. Member of the M. FT tuberculosis PE family, PGRS subfamily of gly-rich proteins FT (see citation below), highly similar to many e.g. FT Q50615|Y0DP_MYCTU HYPOTHETICAL GLYCINE-RICH 40.8 kDa FT PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA FT scores: opt: 1772, E(): 0, (57.3% identity in 513 aa FT overlap); etc. TBparse score is 0.884." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79G09" FT /protein_id="CAE55242.1" FT /translation="MSLLITSPATVAAAATHLAGIGSALSTANAAAAAPTTALSVAGAD FT EVSVLIAALFEAYAQEYQALSAQALAFHDQFVQALNMGAVCYAAAETANATPLQALQTV FT QQNVLTVVNAPTQALLGRPIIGNGANGLPNTGQDGGPGGLLFGNGGNGGSGGVDQAGGN FT GGAAGLIGNGGSGGVGGPGIAGSAGGAGGAGGLLFGNGGPGGAGGIGTTGDGGPGGAGG FT NAIGLFGSGGTGGMGGVGGMGGVGNGGNAGNGGTAGLFGHGGAGGAGGIGSADGGLGGG FT GGNGRFMGNGGVGGAGGYGASGDGGNAGNGGLGGVFGDGGAGGTGGLGDVNGGLAGIGG FT NAGFVRNGGAGGNGQLGSGAVSSAGGMGGNGGLVFGNGGPGGLGGPGTSAGNGGMGGNA FT VGLFGQGGAGGAGGSGFGAGIPGGRGGDGGSGGLIGDGGTGGGAGAGDAAASAGGNGGN FT ARLIGNGGDGGPGMFGGPGGAGGSGGTIFGFAGTPGPS" FT CDS 133020..133769 FT /transl_table=11 FT /locus_tag="Rv0110" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0110, (MTV031.04), len 249 aa. Probable conserved FT integral membrane protein, similar to many e.g. FT AL079308|SCH69_25 from Streptomyces coelicolor (297 aa), FT FASTA scores: opt: 552, E(): 6.1e-29, (45.4% identity in FT 251 aa overlap); P54493|YQGP_BACSU HYPOTHETICAL 56.4 KD FT PROTEIN from Bacillus subtilis (507 aa), FASTA scores: opt: FT 320, E(): 4e-15, (32.4% identity in 210 aa overlap); etc. FT TBparse score is 0.915." FT /db_xref="GOA:O53632" FT /db_xref="InterPro:IPR002610" FT /db_xref="UniProtKB/TrEMBL:O53632" FT /protein_id="CAA17304.1" FT /translation="MRVGPVGHQCAECVREGARAVRQPRTPFGGRQRSATPVVTYTLIS FT LNALVFVMQVTVMGLERQLALWPPAVASGQTYRLVTSAFLHYGAMHLLLNMWALYVVGP FT PLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNTATAGASGAVFGLFGATFMVARRLHL FT DVRWVVALIVINLAFTFLAPAISWQGHVGGLVTGALVAATYVYAPRERRNLIQATVTIT FT VLVAFVVLIGWRTVDLLALFGGRLNLS" FT CDS 133950..136007 FT /transl_table=11 FT /locus_tag="Rv0111" FT /product="POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="2.3.1.-" FT /note="Rv0111, (MTV031.05), len: 685 aa. Possible FT transmembrane acyltransferase (EC 2.3.1.-), equivalent to FT AA22904.1|AL035300 putative acyltransferase from FT Mycobacterium leprae (696 aa). Also similar to others e.g. FT C69975 acyltransferase homolog yrhL from Bacillus subtilis FT (634 aa), FASTA scores: opt: 520, E(): 4e-22, (36.4% FT identity in 382 aa overlap). Very similar to Mycobacterium FT tuberculosis proteins Rv0228, Rv1254, Rv1565c, etc." FT /db_xref="GOA:O53633" FT /db_xref="InterPro:IPR002656" FT /db_xref="UniProtKB/TrEMBL:O53633" FT /protein_id="CAA17305.1" FT /translation="MPARSVPRPRWVAPVRRVGRLAVWDRPERRSGIPALDGLRAIAVA FT LVLASHGGIPGMGGGFIGVDAFFVLSGFLITSLLLDELGRTGRIDLSGFWIRRARRLLP FT ALVLMVLTVSAARALFPDQALTGLRSDAIAAFLWTANWRFVAQNTDYFTQGAPPSPLQH FT TWSLGVEEQYYVVWPLLLIGATLLLAARARRRCRRATVGGVRFAAFLIASLGTMASATA FT AVAFTSAATRDRIYFGTDTRAQALLIGSAAAALLVRDWPSLNRGWCLIRTRWGRRIARL FT LPFVGLAGLAVTTHVATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAVARILAWRPL FT VWLGTISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAATVVLAGASWWLIEQPIRRW FT RPARVPLLPLAAATVASAAAVTMLVVPVGAGPGLREIGLPPGVSAVAAVSPSPPEASQP FT APGPRDPNRPFTVSVFGDSIGWTLMHYLPPTPGFRFIDHTVIGCSLVRGTPYRYIGQTL FT EQRAECDGWPARWSAQVNRDQPDVALLIVGRWETVDRVNEGRWTHIGDPTFDAYLNAEL FT QRALSIVGSTGVRVMVTTVPYSRGGEKPDGRLYPEDQPERVNKWNAMLHNAISQHSNVG FT MIDLNKKLCPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSVRVAS" FT CDS 136289..137245 FT /transl_table=11 FT /gene="gca" FT /locus_tag="Rv0112" FT /product="POSSIBLE GDP-MANNOSE 4,6-DEHYDRATASE GCA FT (GDP-D-MANNOSE DEHYDRATASE)" FT /function="POSSIBLY INVOLVED IN SYNTHESIS OF A-BAND COMMON FT ANTIGEN LIPOPOLYSACCHARIDE. FIRST OF THE THREE STEPS IN THE FT BIOSYNTHESIS OF GDP-FUCOSE FROM GDP-MANNOSE [CATALYTIC FT ACTIVITY: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + FT H2O]." FT /EC_number="4.2.1.47" FT /note="Rv0112, (MTV031.06), len: 318 aa. Possible gca, FT GDP-mannose 4,6-dehydratase (EC 4.2.1.47), similar to FT others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas FT aeruginosa (323 aa), FASTA scores: opt: 415, E(): 4.4e-21, FT (27.0% identity in 318 aa overlap). Similar to Rv3634c, FT Rv3784, etc from Mycobacterium tuberculosis. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature. SEEMS TO BELONG TO THE GDP-MANNOSE FT 4,6-DEHYDRATASE FAMILY. COFACTOR: NAD(+)." FT /db_xref="GOA:O53634" FT /db_xref="HSSP:1DB3" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O53634" FT /protein_id="CAA17306.1" FT /translation="MKVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPTIDPSDLQFNG FT AEVDITDWCSVYDSIATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEALRR FT VRPHAKIIVAGSSAEYGFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSYGMH FT TVVARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVRDLNRAL FT MLMLDKGEAGADYNVGGSIAYEMGDVLKQVIAACKRDDIVPEVDPALLRPTDEKIIYGD FT CSKLAAITGWQQEICLTQTIADMFDYWRSKSESALMV" FT misc_feature 136673..136759 FT /note="PS00061 Short-chain dehydrogenases/reductases family FT signature" FT CDS 137319..137909 FT /transl_table=11 FT /gene="gmhA" FT /locus_tag="Rv0113" FT /standard_name="lpcA" FT /product="PROBABLE SEDOHEPTULOSE-7-PHOSPHATE ISOMERASE GMHA FT (PHOSPHOHEPTOSE ISOMERASE)" FT /function="INVOLVED IN BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED FT GLYCERO-MANNO-HEPTOSE: SYNTHESIS OF GLYCEROMANNOHEPTOSE FT 7-PHOSPHATE (INNER CORE LIPOPOLYSACCHARIDE BIOSYNTHESIS) FT [CATALYTIC ACTIVITY: D-SEDOHEPTULOSE 7-PHOSPHATE = FT D-GLYCERO-ALPHA,BETA-D-MANNO-HEPTOSE 7-PHOSPHATE]." FT /EC_number="5.-.-.-" FT /note="Rv0113, (MTV031.07), len: 196 aa. Probable gmhA FT (alternate gene name: lpcA), sedoheptulose-7-phosphate FT isomerase (EC 5.-.-.-) (see citation below), similar to FT many e.g. AE0005|HPAE000596_11 from Helicobacter pylori FT (192 aa), FASTA scores: opt: 451, E(): 1.9e-24, (45.1% FT identity in 162 aa overlap). BELONGS TO THE SIS FAMILY, FT LPCA SUBFAMILY." FT /db_xref="GOA:P0A604" FT /db_xref="InterPro:IPR001347" FT /db_xref="UniProtKB/Swiss-Prot:P0A604" FT /protein_id="CAA17307.1" FT /translation="MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAG FT ARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTVFA FT RALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADFLIN FT VPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ" FT CDS 137941..138513 FT /transl_table=11 FT /gene="gmhB" FT /locus_tag="Rv0114" FT /product="POSSIBLE D-ALPHA,BETA-D-HEPTOSE-1,7-BIPHOSPHATE FT PHOSPHATASE GMHB (D-GLYCERO-D-MANNO-HEPTOSE 7-PHOSPHATE FT KINASE)" FT /function="INVOLVED IN BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED FT GLYCERO-MANNO-HEPTOSE. INVOLVED IN TWO PATHWAYS, D-ALPHA-D FT PATHWAY [CATALYTIC ACTIVITY: FT D-GLYCERO-ALPHA-D-MANNO-HEPTOSE 1,7-BIPHOSPHATE = FT D-GLYCERO-ALPHA-D-MANNO-HEPTOSE 1-PHOSPHATE] AND L-BETA-D FT PATHWAY [CATALYTIC ACTIVITY: D-GLYCERO-BETA-D-MANNO-HEPTOSE FT 1,7-BIPHOSPHATE = D-GLYCERO-BETA-D-MANNO-HEPTOSE FT 1-PHOSPHATE]." FT /EC_number="2.-.-.-" FT /note="Rv0114, (MTV031.08), len: 190 aa. Possible gmhB, FT D-alpha,beta-D-heptose-1,7-biphosphate phosphatase (EC FT 2.-.-.-) (see citation below), similar to several FT hypothetical proteins and phosphatases e.g. FT HIS7_ECOLI|P06987 imidazoleglycerol-phosphate dehydratase FT (355 aa), FASTA scores: opt: 250, E(): 3.6e-11, (34.0 % FT identity in 141 aa overlap)." FT /db_xref="GOA:O53636" FT /db_xref="InterPro:IPR006543" FT /db_xref="UniProtKB/Swiss-Prot:O53636" FT /protein_id="CAA17308.1" FT /translation="MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARAL FT KKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHRSQ FT RCGCRKPRPGLVLDWLGRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIGGAS FT SGGVADASFDSLWEFAVAVGHARGERG" FT CDS 138513..139673 FT /transl_table=11 FT /gene="hddA" FT /locus_tag="Rv0115" FT /product="POSSIBLE D-ALPHA-D-HEPTOSE-7-PHOSPHATE KINASE FT HDDA" FT /function="INVOLVED IN BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED FT GLYCERO-MANNO-HEPTOSE (D-ALPHA-D PATHWAY) [CATALYTIC FT ACTIVITY: D-GLYCERO-ALPHA,BETA-D-MANNO-HEPTOSE 7-PHOSPHATE FT + ATP = D-GLYCERO-ALPHA-D-MANNO-HEPTOSE 1,7-BIPHOSPHATE]." FT /EC_number="2.-.-.-" FT /note="Rv0115, (MTV031.09), len: 386 aa. Possible hddA, FT D-alpha-D-heptose-7-phosphate kinase (EC 2.-.-.-) (see FT citation below), similar to several hypothetical proteins FT and sugar kinases e.g. AAK27850.1|AF324836_3 FT D-glycero-D-manno-heptose 7-phosphate kinase from FT Aneurinibacillus thermoaerophilus (341 aa); FT AAK80995.1|AE007802_11 Sugar kinase from Clostridium FT acetobutylicum (364 aa). TBparse score is 0.951." FT /db_xref="GOA:O53637" FT /db_xref="InterPro:IPR019793" FT /db_xref="UniProtKB/TrEMBL:O53637" FT /protein_id="CAA17309.1" FT /translation="MAILRGRAPLRLGLGGGGTDVEPYSSQFGGRILSVTIDKYAYAFA FT ERGTGDEIAFRSPDRDRAGQASIDDLASLEEDFPLHVAVYRRVIAEFNGGTPFPLQLAT FT QVDAPPGSGLGSSSALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQDHY FT AAAFGGFNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQQRNV FT VERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRTSTRISNPAIEHA FT YQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFTKGGAVT FT WHIPESTAPVRRGVADAVASALGNAGILLCAGCVLATSHSTWRVPV" FT misc_feature 139188..139220 FT /note="PS00435 Peroxidases proximal heme-ligand signature" FT CDS complement(140267..141022) FT /transl_table=11 FT /locus_tag="Rv0116c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0116c, (MTV031.10c), len: 251 aa. Possible FT conserved membrane protein, showing similarity to several FT hypothetical mycobacterial proteins e.g. Rv1433 from FT Mycobacterium tuberculosis (271 aa); and FT Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 FT aa); to the C-terminal regions of others like Rv0192 from FT Mycobacterium tuberculosis (366 aa), FASTA scores: opt: FT 451, E(): 1.7e-21, (46.7% identity in 270 aa overlap); and FT Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis FT cosmid (366 aa), FASTA scores: opt: 699, E(): 0, (45.7% FT identity in 221 aa overlap). TBparse score is 0.932." FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:O53638" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17310.1" FT /translation="MRRVVRYLSVVVAITLMLTAESVSIATAAVPPLQPIPGVASVSPA FT NGAVVGVAHPVVVTFTTPVTDRRAVERSIRISTPHNTTGHFEWVASNVVRWVPHRYWPP FT HTRVSVGVQELTEGFETGDALIGVASISAHTFTVSRNGEVLRTMPASLGKPSRPTPIGS FT FHAMSKERTVVMDSRTIGIPLNSSDGYLLTAHYAVRVTWSGVYVHSAPWSVNSQGYANV FT SHGCINLSPDNAAWYFDAVTVGDPIEVVG" FT CDS 141200..142144 FT /transl_table=11 FT /gene="oxyS" FT /locus_tag="Rv0117" FT /product="OXIDATIVE STRESS RESPONSE REGULATORY PROTEIN FT OXYS" FT /function="COULD EFFECT FUNCTIONS OF OXYR DURING FT EVOLUTION." FT /note="Rv0117, (MTV031.11), len: 314 aa. OxyS, oxidative FT stress response protein regulatory protein, LysR family FT (see citation below). Similar to many transcription FT regulators and OxyR, the oxidative stress response protein FT of many bacteria. Contains LysR family signature at FT N-terminus. Also contains helix-turn-helix motif at aa FT 16-37 (Score 1543, +4.44 SD). BELONGS TO THE LYSR FAMILY OF FT TRANSCRIPTIONAL REGULATORS. OXYR IS REQUIRED FOR THE FT INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE GENES FT SUCH AS CATALASE, GLUTATHIONE-REDUCTASE, ETC." FT /db_xref="GOA:O33175" FT /db_xref="HSSP:1IXC" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:O33175" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17311.1" FT /translation="MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNV FT TLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTT FT ASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQDSDDVDLVPLYE FT EQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQVIDAAFADHAVSAIPQVET FT DSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALG FT PGSPVARALITCAQALALNEFFDTQLRGITRRR" FT misc_feature 141248..141340 FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS complement(142128..143876) FT /transl_table=11 FT /gene="oxcA" FT /locus_tag="Rv0118c" FT /product="PROBABLE OXALYL-CoA DECARBOXYLASE OXCA" FT /function="INVOLVED IN CATABOLISM OF OXALIC ACID [CATALYTIC FT ACTIVITY: Oxalyl-CoA = formyl-CoA + CO2]." FT /EC_number="4.1.1.8" FT /note="Rv0118c, (MTV031.12c), Len: 582 aa. Probable oxcA, FT oxalyl-CoA decarboxylase (EC 4.1.1.8), highly similar to FT many e.g. FT P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325 FT PROBABLE OXALYL-CoA DECARBOXYLASE from Escherichia coli FT (564 aa); M77128|OXAOXA_1 oxalyl-CoA decarboxylase from FT Oxalobacter formigenes (568 aa), FASTA scores: opt: 2124, FT E():0, (55.6% identity in 568 aa overlap). Also similar to FT mycobacterial IlvB proteins e.g. MLCB1788.46c unknown FT TPP-requiring enzyme from Mycobacterium leprae (548 aa); FT and AL0086|MLCB1788_19 from Mycobacterium leprae (548 aa), FT FASTA scores: opt: 831, E(): 0, (33.9% identity in 567 aa FT overlap)." FT /db_xref="GOA:O53639" FT /db_xref="HSSP:1OZH" FT /db_xref="InterPro:IPR017660" FT /db_xref="UniProtKB/TrEMBL:O53639" FT /protein_id="CAA17312.1" FT /translation="MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARA FT AQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCFPM FT IQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTATSGR FT PGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLV FT LSKGAAYAQADNVIREFVEHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLL FT VGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSALLEAAA FT DRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVN FT EGANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGF FT SGMEFETICRYRLPVTVVILNNGGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELI FT AEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGVESGHLAKLNTTSAATP FT AISGDG" FT CDS 144049..145626 FT /transl_table=11 FT /gene="fadD7" FT /locus_tag="Rv0119" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD7 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv0119, (MTV031.13-MTCI418B.01), len: 525 aa. FT Probable fadD7, fatty-acid-CoA synthetase (EC 6.2.1.-), FT similar to 4-coumarate:CoA ligase of many organisms e.g. FT U39405|PTU39405_1 4-coumarate:CoA ligase from Pinus FT taedaxylem (537 aa), FASTA scores: opt: 483, E(): 8.3e-22, FT (28.2% identity in 440 aa overlap). Contains PS00455 FT Putative AMP-binding domain signature. TBscore is 0.896." FT /db_xref="GOA:O07169" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:O07169" FT /protein_id="CAB09455.1" FT /translation="MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVD FT ELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQA FT AGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPE FT GLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLYHGHG FT LIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEPS FT GRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTET FT PVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDG FT WLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQ FT LYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAV FT AERFGHSV" FT misc_feature 144562..144597 FT /note="PS00455 Putative AMP-binding domain signature, [LIVM FT FY].{2}[STG][STAG]G[ST][STEI][SG].[PASLIVM][KR], info count FT = 22.0" FT CDS complement(145627..147771) FT /transl_table=11 FT /gene="fusA2" FT /locus_tag="Rv0120c" FT /standard_name="fus2" FT /product="PROBABLE ELONGATION FACTOR G FUSA2 (EF-G)" FT /function="INVOLVED IN TRANSLATION MECHANISM. THIS PROTEIN FT MAY PROMOTE THE GTP-DEPENDENT TRANSLOCATION OF THE NASCENT FT PROTEIN CHAIN FROM THE A-SITE TO THE P-SITE OF THE FT RIBOSOME." FT /note="Rv0120c, (MTCI418B.02c), len: 714 aa. Probable fusA2 FT (alternate gene name: fus2), elongation factor G, highly FT similar to others e.g. EFG_ECOLI|P02996 elongation factor G FT (ef-g) from Escherichia coli (703 aa), FASTA scores: opt: FT 1049, E(): 0, (32.5% identity in 717 aa overlap). Also FT similar to fusA1|MTCY210.01 from Mycobacterium tuberculosis FT FASTA score: (39.1% identity in 299 aa overlap); and FT P30767|EFG_MYCLE ELONGATION FACTOR G (EF-G) from FT Mycobacterium leprae (701 aa), FASTA score: (31.7% identity FT in 710 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). BELONGS TO THE GTP-BINDING ELONGATION FT FACTOR FAMILY, EF-G/EF-2 SUBFAMILY." FT /db_xref="GOA:O07170" FT /db_xref="HSSP:2EFG" FT /db_xref="InterPro:IPR004161" FT /db_xref="UniProtKB/Swiss-Prot:O07170" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09448.1" FT /translation="MADRVNASQGAAAAPTANGPGGVRNVVLVGPSGGGKTTLIEALLV FT AAKVLSRPGSVTEGTTVCDFDEAEIRQQRSVGLAVASLAYDGIKVNLVDTPGYADFVGE FT LRAGLRAADCALFVIAANEGVDEPTKSLWQECSQVGMPRAVVITKLDHARANYREALTA FT AQDAFGDKVLPLYLPSGDGLIGLLSQALYEYADGKRTTRTPAESDTERIEEARGALIEG FT IIEESEDESLMERYLGGETIDESVLIQDLEKAVARGSFFPVIPVCSSTGVGTLELLEVA FT TRGFPSPMEHPLPEVFTPQGVPHAELACDNDAPLLAEVVKTTSDPYVGRVSLVRVFSGT FT IRPDTTVHVSGHFSSFFGGGTSNTHPDHDEDERIGVLSFPLGKQQRPAAAVVAGDICAI FT GKLSRAETGDTLSDKAEPLVLKPWTMPEPLLPIAIAAHAKTDEDKLSVGLGRLAAEDPT FT LRIEQNQETHQVVLWCMGEAHAGVVLDTLANRYGVSVDTIELRVPLRETFAGNAKGHGR FT HIKQSGGHGQYGVCDIEVEPLPEGSGFEFLDKVVGGAVPRQFIPNVEKGVRAQMDKGVH FT AGYPVVDIRVTLLDGKAHSVDSSDFAFQMAGALALREAAAATKVILLEPIDEISVLVPD FT DFVGAVLGDLSSRRGRVLGTETAGHDRTVIKAEVPQVELTRYAIDLRSLAHGAASFTRS FT FARYEPMPESAAARVKAGAG" FT misc_feature complement(147661..147684) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(147908..148342) FT /transl_table=11 FT /locus_tag="Rv0121c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved FT hypothetical protein, showing some similarity with others FT proteins from Mycobacterium tuberculosis e.g. Rv1155, FT Rv1875, Rv2074, etc." FT /db_xref="GOA:O07171" FT /db_xref="InterPro:IPR019967" FT /db_xref="UniProtKB/TrEMBL:O07171" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09449.1" FT /translation="MGEFDPKLRFAQSPVARLATSTPDGTPHLVPVVFALGARRPAEAT FT GADVIYTAVDAKRKTTQRLRRLANLEHNPRASVLVDSYADDWTQLWWVRADGVAAIHRD FT GEVMRAAYRLLRAKYAQYQSVPLNGPVIAIAVQRWASWHA" FT CDS 148491..148859 FT /transl_table=11 FT /locus_tag="Rv0122" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0122, (MTCI418B.04), len: 133 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:O07172" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09450.1" FT /translation="MAGSVSAAAGIGWVGLNVTETNRDQCYRVERTTVDALTHPEYRVH FT TRGVQRVRVTRNARKHRVSKHRIVAAMRHCGVPVIQEDGSLYYQGRDTSGRLTEVVAVE FT ADDGDLIITHAMPKEWKR" FT CDS 148856..149224 FT /transl_table=11 FT /locus_tag="Rv0123" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0123, (MTCI418B.05), len: 133 aa. Hypothetical FT unknown protein." FT /db_xref="GOA:O07173" FT /db_xref="UniProtKB/TrEMBL:O07173" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09451.1" FT /translation="MTKKPRNPADYVIGDDVEVSDVDLKQEEVYVDGERLTDERVEQMA FT SESLRLAREREANLIPGGKSLSGGSAHSPAVQVVVSKATHAKLKELARSRKMSVSKLLR FT PVLDEFVQRETGRILPRR" FT CDS 149533..150996 FT /transl_table=11 FT /gene="PE_PGRS2" FT /locus_tag="Rv0124" FT /product="PE-PGRS FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0124, (MTCI418B.06), len: 487 aa. Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see citation below), highly similar to FT many e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis FT (498 aa), FASTA scores: opt: 1730, E(): 0, (60.7% identity FT in 504 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79G08" FT /protein_id="CAE55243.1" FT /translation="MSFVSVAPEIVVAAATDLAGIGSAISAANAAAAAPTTAVLAAGAD FT EVSAAIAALFSGHAQAYQALSAQAAAFHQQFVQTLAGGAGAYAAAEAQVEQQLLAAINA FT PTQALLGRPLIGNGADGAPGTGQAGGAGGILYGNGGNGGSGAAGQAGGAGGPAGLIGHG FT GSGGAGGSGAAGGAGGHGGWLWGNGGVGGSGGAGVGAGVAGGHGGAGGAAGLWGAGGGG FT GNGGNGADANIVSGGDGGLGGAGGGGGWLYGDGGAGGHGGQGAIGLGGGAGGDGGQGGA FT GRGLWGTGGAGGHGGQGGGTGGPPLPGQAGMGAAGGAGGLIGNGGAGGDGGVGASGGVA FT GVGGAGGNAMLIGHGGAGGAGGDSSFANGAAGGAGGAGGHLFGNGGSGGHGGAVTAGNT FT GIGGAGGVGGDARLIGHGGAGGAGGDRAGALVGRDGGPGGNGGAGGQLYGNGGDGAPGT FT GGTLQAAVSGLVTALFGAPGQPGDTGQPG" FT CDS 151148..152215 FT /transl_table=11 FT /gene="pepA" FT /locus_tag="Rv0125" FT /standard_name="mtb32a" FT /product="PROBABLE SERINE PROTEASE PEPA (SERINE PROTEINASE) FT (MTB32A)" FT /function="UNKNOWN; POSSIBLY HYDROLYZES PEPTIDES AND/OR FT PROTEINS (SEEMS TO CLEAVE PREFERENTIALLY AFTER SERINE FT RESIDUES)." FT /EC_number="3.4.21.-" FT /note="Rv0125, (MTCI418B.07, MTB32A), len: 355 aa. Probable FT pepA (alternate gene name: mtb32a), serine protease (EC FT 3.4.21.-) (see Skeiky et al., 1999), highly similar to FT other proteases e.g. HHOB_ECOLI|P31137 protease hhob FT precursor (355 aa), FASTA scores: opt: 400, E(): 3.8e-14, FT (32.4% identity in 346 aa overlap). Also similar to Q50320 FT 34 kDa PROTEIN PRECURSOR from Mycobacterium tuberculosis FT (361 aa), FASTA scores: opt: 1689, E(): 0, (70.7% identity FT in 362 aa overlap). Contains PS00135 Serine proteases, FT trypsin family, serine active site. Has a putative signal FT sequence at the N-terminus. BELONGS TO THE SERINE PROTEASE FT FAMILY." FT /db_xref="GOA:O07175" FT /db_xref="HSSP:1LCY" FT /db_xref="InterPro:IPR018114" FT /db_xref="UniProtKB/TrEMBL:O07175" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09453.1" FT /translation="MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFADF FT PALPLDPSAMVAQVGPQVVNINTKLGYNNAVGAGTGIVIDPNGVVLTNNHVIAGATDIN FT AFSVGSGQTYGVDVVGYDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSGGQG FT GTPRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQVVGM FT NTAASDNFQLSQGGQGFAIPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNGNG FT ARVQRVVGSAPAASLGISTGDVITAVDGAPINSATAMADALNGHHPGDVISVTWQTKSG FT GTRTGNVTLAEGPPA" FT misc_feature 151751..151786 FT /note="PS00135 Serine proteases, trypsin family, serine FT active site" FT CDS 152324..154129 FT /transl_table=11 FT /gene="treS" FT /locus_tag="Rv0126" FT /product="TREHALOSE SYNTHASE TRES" FT /function="INVOLVED IN TREHALOSE BIOSYNTHESIS (PROTECTIVE FT EFFECT). CONVERTS MALTOSE TO TREHALOSE. Mycobacteria can FT produce trehalose from glucose 6-phosphate and UDP-glucose FT (the OtsA-OtsB pathway) from glycogen-like FT alpha(1-->4)-linked glucose polymers (the TreY-TreZ FT pathway) and from maltose (the TreS pathway)." FT /EC_number="5.4.99.-" FT /note="Rv0126, (MTCI418B.08), len: 601 aa. treS, trehalose FT synthase (EC 5.4.99.-) (see citation below), highly similar FT to others e.g. CAA04601.2|AJ001205 putative trehalose FT synthase from Streptomyces coelicolor (566 aa); FT S71450|1536814|BAA11303.1|D78198 trehalose synthase FT maltose-specific from Pimelobacter sp. strain R48 (573 aa). FT Also similar to MAL1_DROME|P07191 possible maltase FT precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7% FT identity in 504 aa overlap); and similar to proteins FT associated with amino-acid transport e.g. Q64319 rat FT protein which stimulates transport of cystine and dibasic FT and neutral amino acids (683 aa), FASTA scores: opt: 839, FT E(): 0, (32.0% identity in 531 aa overlap). Also similar to FT several other Mycobacterium tuberculosis proteins e.g. FT Rv2471 FASTA score: (31.7% identity in 164 aa overlap)." FT /db_xref="GOA:O07176" FT /db_xref="HSSP:1M53" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/TrEMBL:O07176" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09454.1" FT /translation="MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWFK FT HAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYDSPLRDGGYDIR FT DFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHPWFQESRRDPDGPYGDY FT YVWSDTSERYTDARIIFVDTEESNWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMID FT VIRFWLGLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEA FT NQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIAQTPPIPDMA FT QWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDNDRNQIELF FT TALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPP FT SQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLAYV FT RQVAGDDGDTVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIGQVPYLLTLPG FT HGFYWFQLTTHEVGAPPTCGGERRL" FT repeat_region 154073..154125 FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class III. See citation below." FT repeat_region 154126..154178 FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT repeat_region 154179..154231 FT /note="53 bp Mycobacterial Interspersed Repetitive Unit, FT Class II" FT CDS 154232..155599 FT /transl_table=11 FT /locus_tag="Rv0127" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0127, (MTCI418B.09, MTCI5.01), len: 455 aa. FT Conserved hypothetical protein, highly similar to various FT proteins e.g. AJ0012|SCJ001205_4 hypothetical protein from FT Streptomyces coelicolor A3(2) (464 aa), FASTA scores: opt: FT 412, E(): 1.1e-19, (40.6% identity in 485 aa overlap); FT AJ0012|SCJ001206_5 hypothetical protein from Streptomyces FT coelicolor A3(2) (453 aa), FASTA scores: opt: 403, E(): 4.3 FT e-19, (36.5% identity in 455 aa overlap)." FT /db_xref="InterPro:IPR002575" FT /db_xref="UniProtKB/TrEMBL:O07177" FT /protein_id="CAB09456.1" FT /translation="MTRSDTLATKLPWSDWLSRQRWYAGRNRELATVKPGVVVALRHNL FT DLVLVDVTYTDGATERYQVLVGWDFEPASEYGTKAAIGVADDRTGFDALYDVAGPQFLL FT SLIVSSAVCGTSTGEVTFTREPDVELPFAAQPRVCDAEQSNTSVIFDRRAILKVFRRVS FT SGINPDIELNRVLTRAGNPHVARLLGAYQFGRPNRSPTDALAYALGMVTEYEANAAEGW FT AMATASVRDLFAEGDLYAHEVGGDFAGESYRLGEAVASVHATLADSLGTAQATFPVDRM FT LARLSSTVAVVPELREYAPTIEQQFQKLAAEAITVQRVHGDLHLGQVLRTPESWLLIDF FT EGEPGQPLDERRAPDSPLRDVAGVLRSFEYAAYGPLVDQATDKQLAARAREWVERNRAA FT FCDGYAVASGIDPRDSALLLGAYELDKAVYETGYETRHRPGWLPIPLRSIARLTAS" FT CDS 155667..156446 FT /transl_table=11 FT /locus_tag="Rv0128" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0128, (MTCI5.02), len: 259 aa. Probable conserved FT transmembrane protein, with some similarity to Rv3064c and FT other bacterial proteins e.g. FT AAK85977.1|AE007957|AGR_C_254p from Agrobacterium FT tumefaciens (206 aa)." FT /db_xref="GOA:P96805" FT /db_xref="InterPro:IPR010699" FT /db_xref="UniProtKB/TrEMBL:P96805" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07034.1" FT /translation="MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQR FT AVLGLFGDDAWMSVTASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAAGV FT DIMLGGWHESMLDFVPILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIERHL FT AGGKVEDWLGYFLLHASFVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLHADRR FT GLVNQKRPQPGKRLFRALRRGELDSGTSTPATNYGSS" FT CDS complement(156578..157600) FT /transl_table=11 FT /gene="fbpC" FT /locus_tag="Rv0129c" FT /standard_name="mpt45; 85C; fbpC2" FT /product="SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 FT COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) FT (FIBRONECTIN-BINDING PROTEIN C)" FT /function="PROTEINS OF THE ANTIGEN 85 COMPLEX ARE FT RESPONSIBLE FOR THE HIGH AFFINITY OF MYCOBACTERIA TO FT FIBRONECTIN. POSSESSES A MYCOLYLTRANSFERASE ACTIVITY FT REQUIRED FOR THE BIOGENESIS OF TREHALOSE DIMYCOLATE (CORD FT FACTOR), A DOMINANT STRUCTURE NECESSARY FOR MAINTAINING FT CELL WALL INTEGRITY." FT /EC_number="2.3.1.-" FT /note="Rv0129c, (MT0137, MTCI5.03c), len: 340 aa. fbpC FT (alternate gene names: mpt45, 85C, fbpC2), secreted antigen FT 85c (fibronectin-binding protein C) (mycolyl transferase FT 85C) (EC 2.3.1.-) (see citations below), also highly FT similar to other Mycobacterial antigen precursors e.g. FT A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from FT Mycobacterium leprae (333 aa), FASTA scores: opt: 1937, FT E(): 0, (81.4% identity in 333 aa overlap); etc." FT /db_xref="GOA:P0A4V4" FT /db_xref="InterPro:IPR000801" FT /db_xref="PDB:1DQY" FT /db_xref="UniProtKB/Swiss-Prot:P0A4V4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55244.1" FT /translation="MTFFEQVRRLRSAATTLPRRLAIAAMGAVLVYGLVGTFGGPATAG FT AFSRPGLPVEYLQVPSASMGRDIKVQFQGGGPHAVYLLDGLRAQDDYNGWDINTPAFEE FT YYQSGLSVIMPVGGQSSFYTDWYQPSQSNGQNYTYKWETFLTREMPAWLQANKGVSPTG FT NAAVGLSMSGGSALILAAYYPQQFPYAASLSGFLNPSEGWWPTLIGLAMNDSGGYNANS FT MWGPSSDPAWKRNDPMVQIPRLVANNTRIWVYCGNGTPSDLGGDNIPAKFLEGLTLRTN FT QTFRDTYAADGGRNGVFNFPPNGTHSWPYWNEQLVAMKADIQHVLNGATPPAAPAAPAA FT " FT CDS 157847..158302 FT /transl_table=11 FT /locus_tag="Rv0130" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0130, (MTCI5.04), len: 151 aa. Conserved FT hypothetical protein, most similar to AL096811|SCI30A_19 FT from Streptomyces coelicolor (153 aa), FASTA scores: opt: FT 639, E(): 0, (60.8% identity in 148 aa overlap). Also FT similar to NODN_RHILV|P08634 nodulation protein from FT Rhizobium leguminosarum bv. viciae plasmid pRL1JI (161 aa), FT FASTA scores: opt: 406, E(): 1e-21, (43.9% identity in 148 FT aa overlap; and to O30041 MONOAMINE OXIDASE REGULATORY FT PROTEIN (146 aa), FASTA scores: opt: 219, E(): 1.1e-08, FT (30.8% identity in 133 aa overlap)." FT /db_xref="GOA:P96807" FT /db_xref="InterPro:IPR002539" FT /db_xref="PDB:2C2I" FT /db_xref="UniProtKB/Swiss-Prot:P96807" FT /protein_id="CAB07036.1" FT /translation="MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWIH FT VDPERAAAGPFGTTIAHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPVGS FT RVRATSSLVGVEDLGNGTVQATVSTTVEVEGSAKPACVAESIVRYVA" FT CDS complement(158315..159658) FT /transl_table=11 FT /gene="fadE1" FT /locus_tag="Rv0131c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE1" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv0131c, (MTCI5.05c), len: 447 aa. Probable fadE1, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain FT specific precursor (412 aa), FASTA scores: opt: 522, E(): FT 1.4e-23, (30.1% identity in 425 aa overlap). Also highly FT similar to MTCI5_28 from Mycobacterium tuberculosis." FT /db_xref="GOA:P96808" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:P96808" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07037.1" FT /translation="MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVA FT LDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSRWA FT PSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLFVTA FT ATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEI FT VRNVGVGAESTRHASHGYIRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIA FT LARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHD FT YQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATE FT LHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF" FT CDS complement(159700..160782) FT /transl_table=11 FT /gene="fgd2" FT /locus_tag="Rv0132c" FT /product="PUTATIVE F420-DEPENDENT GLUCOSE-6-PHOSPHATE FT DEHYDROGENASE FGD2" FT /function="CATALYZES OXIDATION OF GLUCOSE-6-PHOSPHATE TO FT 6-PHOSPHOGLUCONOLACTONE USING COENZYME F420 (AN FT *-HYDROXY-5-DEAZAFLAVIN DERIVATIVE) AS THE ELECTRON FT ACCEPTOR." FT /EC_number="1.-.-.-" FT /note="Rv0132c, (MTCI5.06c), len: 360 aa. Putative fgd2, FT F420-dependent glucose-6-phosphate dehydrogenase (EC FT 1.-.-.-), highly similar to many from Mycobacteria e.g. FT AAD38167|g5031431 from Mycobacterium chelonae. Also similar FT to MJ1534|Q58929 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN FT REDUCTASE from METHANOCOCCUS JANNASCHII (342 aa), FASTA FT scores: opt: 285, E(): 7.9e-11, (28.4% identity in 292 aa FT overlap). And also similar to Rv0953c, Rv0791c, etc from FT Mycobacterium tuberculosis. Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site." FT /db_xref="GOA:P96809" FT /db_xref="InterPro:IPR019945" FT /db_xref="UniProtKB/TrEMBL:P96809" FT /protein_id="CAB07038.1" FT /translation="MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVG FT VVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNSTS FT SILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNYRE FT RHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAG FT RYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLW FT RFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFP FT QDDPITAIDFYRTNVLPELR" FT misc_feature complement(160702..160734) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 160869..161474 FT /transl_table=11 FT /locus_tag="Rv0133" FT /product="PROBABLE ACETYLTRANSFERASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="2.3.1.-" FT /note="Rv0133, (MTCI5.07), len: 201 aa. Probable FT acetyltransferase (EC 2.3.1.-), highly similar to others FT e.g. PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199 FT aa), FASTA scores: opt: 341, E(): 1.8e-16, (33.3% identity FT in 201 aa overlap)." FT /db_xref="GOA:P96810" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:P96810" FT /protein_id="CAB07039.1" FT /translation="MTPQARPARRADVRELSRTMARAFYDDPVMSWLLSNDNARTARLT FT RLFATIVRHQHLAGGGVEVARGAAGIGGAALWDPPDRWRESRRQQLAMTPGFLRVFGFR FT TAKARAALDVMMRVHPEEPHWYLAAIGSDPTVRGQGFGQVLMRSRLDRCDAEHCPAYLE FT STKPENVPYYQRFGFRVTREIALPDAGPPLWAMWREPR" FT CDS 161771..162673 FT /transl_table=11 FT /gene="ephF" FT /locus_tag="Rv0134" FT /product="POSSIBLE EPOXIDE HYDROLASE EPHF (EPOXIDE FT HYDRATASE) (ARENE-OXIDE HYDRATASE)" FT /function="THOUGHT TO BE INVOLVED IN DETOXIFICATION FT REACTIONS FOLLOWING OXIDATIVE DAMAGE TO LIPIDS [CATALYTIC FT ACTIVITY: AN EPOXIDE + H(2)O = A GLYCOL]." FT /EC_number="3.3.2.3" FT /note="Rv0134, (MTCI5.08), len: 300 aa. Possible ephE, FT epoxide hydrolase (EC 3.3.2.3) (see citation below), FT similar to others e.g. Q39856 epoxide hydrolase (341 aa), FT FASTA scores: opt: 369, E(): 4.6e-17, (27.2% identity in FT 335 aa overlap); ETC. Also similar to MTCY09F9.26c from FT Mycobacterium tuberculosis (29.5% identity in 346 aa FT overlap)." FT /db_xref="GOA:P96811" FT /db_xref="HSSP:1EHY" FT /db_xref="InterPro:IPR000639" FT /db_xref="UniProtKB/TrEMBL:P96811" FT /protein_id="CAB07040.1" FT /translation="MIALPALEGVEHRHVDVAEGVRIHVADAGPADGPAVMLVHGFPQN FT WWEWRDLIGPLAADGNRVLCPDLRGAGWSSAPRSRYTKTEMADDLAAVLDGLGVAKVKL FT VAHDWGGPVAFIMMLRHPEKVTGFFGVNTVAPWVKRDLGMLRNMWRFWYQIPMSLPVIG FT PRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAEAGSRWYRTFQTREML FT RWLRGEYNDARVDVPVRWLHGTGDPVITPDLLDGYAERASDFEVELVDGVGHWIVEQRP FT ELVLDRVRAFLAAGTEQRD" FT CDS complement(162644..163249) FT /transl_table=11 FT /locus_tag="Rv0135c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="COULD BE INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0135c, (MTCI5.09c), len: 201 aa. Possible FT transcriptional regulator, weakly similar to others e.g. FT P32398|YHGD_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR FT from Bacillus subtilis (191 aa), FASTA scores: opt: 145, FT E(): 0.0012, (21.0% identity in 162 aa overlap)." FT /db_xref="GOA:P96812" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:P96812" FT /protein_id="CAB07041.1" FT /translation="MTAVAAGALVVETDSFRLRLLDGLVASIGERGYRATTVSDIVRHA FT RTSKRTFYDRFTSKEQCFLELLLADNETLGNSIRAAVDPNADWHDQIRQAVEAYVTHIE FT SRPAVTLSWIREFPSLGAAAYPVQRRGMEQLTSLLIELSASPGFRRANLPPLNVPLAVI FT LLGGLRELTALTVEDGQPIRNIVEPAVDASIALLGPRS" FT CDS 163366..164691 FT /transl_table=11 FT /gene="cyp138" FT /locus_tag="Rv0136" FT /product="PROBABLE CYTOCHROME P450 138 CYP138" FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND FT XENOBIOTICS." FT /EC_number="1.14.-.-" FT /note="Rv0136, (MT0144, MTCI5.10), len: 441 aa. Probable FT cyp138, cytochrome P450 138 (EC 1.14.-.-), similar to FT others e.g. SLR0574|Q59990 from SYNECHOCYSTIS SP. (444 aa), FT FASTA scores: opt: 315, E(): 1e-13, (25.7% identity in 416 FT aa overlap); etc. Also similar to MTV039_6 from FT Mycobacterium tuberculosis (472 aa), FASTA score: (38.2% FT identity in 442 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop); and PS00086 FT Cytochrome P450 cysteine heme-iron ligand signature. FT BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P63717" FT /db_xref="InterPro:IPR002401" FT /db_xref="UniProtKB/Swiss-Prot:P63717" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07042.1" FT /translation="MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVRR FT YGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGDDH FT RRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILRAIF FT GAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVIDKLIE FT AERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLGWAFER FT LSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGEWVIPRG FT YSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAAFANMEMD FT VVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR" FT misc_feature 163699..163722 FT /note="PS00017 ATP/GTP-binding site motif A" FT misc_feature 164506..164535 FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature" FT CDS complement(164712..165260) FT /transl_table=11 FT /gene="msrA" FT /locus_tag="Rv0137c" FT /product="PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE FT MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE MET(O) FT REDUCTASE)" FT /function="HAS AN IMPORTANT FUNCTION AS A REPAIR ENZYME FOR FT PROTEINS THAT HAVE BEEN INACTIVATED BY OXIDATION. CATALYZES FT THE REVERSIBLE OXIDATION-REDUCTION OF METHIONINE SULFOXIDE FT IN PROTEINS TO METHIONINE [CATALYTIC ACTIVITY: Protein FT L-methionine + oxidized thioredoxin = protein L-methionine FT S-oxide + reduced thioredoxin]." FT /EC_number="1.8.4.6" FT /note="Rv0137c, (MTCI5.11c), len: 167 aa. Probable msrA, FT peptide methionine sulfoxide reductase (EC 1.8.4.6), FT equivalent to CAC32179.1|AL583926 putative peptide FT methionine sulfoxide from Mycobacterium leprae (177 aa). FT Highly similar to others e.g. CAC18703.1|AL451182 putative FT peptide methionine sulfoxide reductase from Streptomyces FT coelicolor (172 aa); PMSR_SCHPO|Q09859 putative peptide FT methionine sulfoxide reductase from Streptomyces (187 aa), FT FASTA scores: opt: 468, E(): 9.9e-26, (45.6% identity in FT 158 aa overlap); etc. BELONGS TO THE MSRA FAMILY." FT /db_xref="GOA:P0A5L0" FT /db_xref="InterPro:IPR002569" FT /db_xref="PDB:1NWA" FT /db_xref="UniProtKB/Swiss-Prot:P0A5L0" FT /protein_id="CAB07043.1" FT /translation="MTSNQKAILAGGCFWGLQDLIRNQPGVVSTRVGYSGGNIPNATYR FT NHGTHAEAVEIIFDPTVTDYRTLLEFFFQIHDPTTKDRQGNDRGTSYRSAIFYFDEQQK FT RIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHFVRPGWRL FT PRRTAESALRASLSPELGT" FT CDS 165323..165826 FT /transl_table=11 FT /locus_tag="Rv0138" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0138, (MTCI5.12), len: 167 aa. Conserved FT hypothetical protein, showing weak similarity to FT Q10827|YT10_MYCTU HYPOTHETICAL 17.0 KDA PROTEIN from FT Mycobacterium tuberculosis (147 aa), FASTA scores: opt: FT 131, E(): 0.047, (31.15% identity in 106 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P96815" FT /protein_id="CAB07044.1" FT /translation="MSASEFSRAELAAAFEKFEKTVARAAATRDWDCWVQHYTPDVEYI FT EHAAGIMRGRQRVRAWIQETMTTFPGSHMVAFPSLWSVIDESTGRIICELDNPMLDPGD FT GSVISATNISIITYAGNGQWCRQEDIYNPLRFLRAAMKWCRKAQELGTLDEDAARWMRR FT HGGP" FT CDS 165827..166849 FT /transl_table=11 FT /locus_tag="Rv0139" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0139, (MTCI5.13), len: 340 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to others e.g. FT O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa), FT FASTA scores: opt: 507, E (): 5.8e-27, (31.1% identity in FT 328 aa overlap); TRE_STRGR|P29782 dtdp-glucose FT 4,6-dehydratase (328 aa), FASTA scores: opt: 254, E(): FT 2.6e-10, (29.0% identity in 307 aa overlap)." FT /db_xref="GOA:P96816" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P96816" FT /protein_id="CAB07045.1" FT /translation="MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRS FT IDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNVLD FT VATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYAHDA FT GLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAVGVDDAARALILA FT AERGRNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTG FT KDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVGKDPAAS FT " FT CDS 166910..167290 FT /transl_table=11 FT /locus_tag="Rv0140" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0140, (MTCI5.14), len: 126 aa. Conserved FT hypothetical protein, similar to others e.g. FT P74567|D90916_48 HYPOTHETICAL 20.8 KDP PROTEIN from FT Synechocystis sp. (180 aa), FASTA scores: opt: 229, E(): FT 4.7e-10, (36.1% identity in 108 aa overlap). Also similar FT to Rv1056 and Rv1670 from Mycobacterium tuberculosis." FT /db_xref="InterPro:IPR007361" FT /db_xref="UniProtKB/TrEMBL:P96817" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07046.1" FT /translation="MSNRIVLEPSADHPITIEPTNRRVQVRVNGEVVADTAAALCLQEA FT SYPAVQYIPLADVVQDRLIRTETSTYCPFKGEASYYSVTTDAGDIVDDVMWTYENPYPA FT VAAIAGHVACYPDKAEISIFPG" FT CDS complement(167271..167681) FT /transl_table=11 FT /locus_tag="Rv0141c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0141c, (MTCI5.15c), len: 136 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P96818" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07047.1" FT /translation="MTPFDDPQAELAWMFLQSLCEGGDLDEGFALLSNDFTYWSIVTRT FT ELDKKTFRRAVERRKQVFEVNIELIRCVNEGETVVVEGHCDGVSADRTRYDSPFVCIFE FT TRDGMIISLREYSDTQSLAEVYPVACATPGRC" FT CDS 167711..168637 FT /transl_table=11 FT /locus_tag="Rv0142" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0142, (MTCI5.16), len: 208 aa. Conserved FT hypothetical protein, similar, except in N-terminus, to FT AB88922.1|AL353862 hypothetical protein SCE34.20 from FT Streptomyces coelicolor (326 aa)." FT /db_xref="GOA:P96819" FT /db_xref="UniProtKB/TrEMBL:P96819" FT /protein_id="CAB07048.1" FT /translation="MRSIDVVVEAVVTFAGAAGFAHTLAPLRRGQQDPCFRVPGDGTIW FT RTSLLPTGPVTARISRAGRDAARCVAWGSGAEEFVDMAPAMLGAADDASDFVPLHPAVA FT AAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAFRSWRLLVSKYGTQAPGPAPPGMR FT VPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLERLVSLPAARAAEALTSLPG FT VGVWTAAETTQRVFGDADAVSVGDYHIPKMIGWTLVGRPVDDAGMLELLEPMRPHRHRV FT VRLLEASGLAREPRRGPRLPVQNIRAL" FT CDS complement(168704..170182) FT /transl_table=11 FT /locus_tag="Rv0143c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN; POSSIBLY ION CHANNEL INVOLVED IN FT TRANSPORT OF CHLORIDE ACROSS THE MEMBRANE." FT /note="Rv0143c, (MTCI5.17c), len: 492 aa. Probable FT conserved transmembrane protein, CIC family possibly FT involved in transport of chloride, similar to others and FT hypothetical proteins e.g. O28857 PUTATIVE CHLORIDE CHANNEL FT from Archaeoglobus fulgidus (589 aa), FASTA scores: opt: FT 966, E(): 0, (37.7% identity in 453 aa overlap); FT YADQ_ECOLI|P37019 hypothetical 46.0 kDa protein (436 aa), FT FASTA scores: opt: 452, E(): 2.4e-20, (28.0% identity in FT 460 aa overlap)." FT /db_xref="GOA:P96820" FT /db_xref="InterPro:IPR001807" FT /db_xref="UniProtKB/TrEMBL:P96820" FT /protein_id="CAB07049.1" FT /translation="MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRFGVSIRSAGYLR FT KWFLLGITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGFARPW FT AIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGRAVLVKMVASALTI FT GSGGSGGREGPTAQISAGFCSLLTRRLNLSNEDGRTAVALGIGAGIGAIFAAPLGGAAL FT GASIPYRDDFDYRNLLPGFIASGTAYAVLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVV FT IGLIAAAVGYLYARVFHASVAITRRLPGGPVLKPAIGGLLVGLLGLPIPQILSSGYGWA FT QLAADRGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWRLG FT ELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVPGAIIAVGIAA FT LLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA" FT CDS 170284..171126 FT /transl_table=11 FT /locus_tag="Rv0144" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0144, (MTCI5.18), len: 280 aa. Probable FT transcriptional regulator, possibly tetR family. Has region FT similar to others e.g. FT Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID OPERON FT REPRESSOR (GUS OPERON) from Escherichia coli strains K12 FT and O157:H7 (196 aa), FASTA scores: opt: 214, E(): 1.1e-06, FT (26.0% identity in 196 aa overlap). Contains probable FT helix-turn helix motif from aa 109-130 (Score 1463, +4.17 FT SD). COULD BELONG TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:P96821" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:P96821" FT /protein_id="CAB07050.1" FT /translation="MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGAK FT LTSSVASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQVFSER FT GYDGATFQEIAVRADLTRPAINHYFANKRVLYQEVVEQTHELVIVAGIERARREPTLMG FT RLAVVVDFAMEADAQYPASTAFLATTVLESQRHPELSRTENDAVRATREFLVWAVNDAI FT ERGELAADVDVSSLAETLLVVLCGVGFYIGFVGSYQRMATITDSFQQLLAGTLWRPPT" FT CDS 171215..172168 FT /transl_table=11 FT /locus_tag="Rv0145" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0145, (MTCI5.19), len: 317 aa. Conserved FT hypothetical protein, highly similar to many e.g. FT CAC32172.1|AL583926 conserved hypothetical protein from FT Mycobacterium leprae (310 aa); and several Mycobacterium FT tuberculosis proteins e.g. Rv0726c, Rv0731c, etc." FT /db_xref="GOA:P96822" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/Swiss-Prot:P96822" FT /protein_id="CAB07051.1" FT /translation="MTELDDVSSLPSSRRTAGDTWAITESVGATALGVAAARAVETAAT FT NPLIRDEFAKVLVSSAGTAWARLADADLAWLDGDQLGRRVHRVACDYQAVRTHFFDEYF FT GAAVDAGVRQVVILAAGLDARAYRLNWPAGTVVYEIDQPSVLEYKAGILQSHGAVPTAR FT RHAVAVDLRDDWPAALIAAGFDGTQPTAWLAEGLLPYLPGDAADRLFDMVTALSAPGSQ FT VAVEAFTMNTKGNTQRWNRMRERLGLDIDVQALTYHEPDRSDAAQWLATHGWQVHSVSN FT REEMARLGRAIPQDLVDETVRTTLLRGRLVTPAQPA" FT CDS 172211..173143 FT /transl_table=11 FT /locus_tag="Rv0146" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0146, (MTCI5.20), len: 310 aa. Conserved FT hypothetical protein, highly similar to others e.g. FT AC30975.1|AL583924 conserved hypothetical protein from FT Mycobacterium leprae (304 aa); and several Mycobacterium FT tuberculosis proteins e.g. Rv0726c, Rv0731c, etc." FT /db_xref="GOA:P96823" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/Swiss-Prot:P96823" FT /protein_id="CAB07052.1" FT /translation="MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLV FT TNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAGIR FT QVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPADLR FT QDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVH FT GEERRAEMRARFKKVADVLGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDE FT MRRVGRWVEGVPMADDPTAFAEFVTAERL" FT CDS 173238..174758 FT /transl_table=11 FT /locus_tag="Rv0147" FT /product="PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM [CATALYTIC ACTIVITY: An aldehyde + NAD+ + H2O = FT an acid + NADH]." FT /EC_number="1.2.1.-" FT /note="Rv0147, (MTCI5.21), len: 506 aa. Probable aldehyde FT dehydrogenase (NAD+) dependent (EC 1.2.1.-), similar to FT others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric FT NADP-preferring) (452 aa), FASTA scores: opt: 1291, E(): 0, FT (43.9% identity in 453 aa overlap). Also similar to several FT Mycobacterium tuberculosis aledehyde dehydrogenases e.g. FT Rv0768, Rv2858c, etc. Contains PS00687 aldehyde FT dehydrogenases glutamic acid active site, and PS00070 FT aldehyde dehydrogenases cysteine active site. BELONGS TO FT THE ALDEHYDE DEHYDROGENASES FAMILY." FT /db_xref="GOA:P96824" FT /db_xref="HSSP:1AD3" FT /db_xref="InterPro:IPR016162" FT /db_xref="UniProtKB/TrEMBL:P96824" FT /protein_id="CAB07053.1" FT /translation="MSDRVKAVAPPDGRTMMTTESVARKTQKSETEAPREPAPVSDEKQ FT TDVAKTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLDRNPFEAY FT LADIATTSAEAKYAAKRVRRWMRRRYLLLEVPQLPGRGWVEYEPYGTVLIIGAWNYPFY FT LTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTELVYRYLDTEAIAVVQGDGAVSQELIA FT QGFDRVMFTGGTEIGRKVYEGAAPHLTPVTLELGGKSPVIVAADADVDVAAKRIAWIKL FT LNAGQTCVAPDYVLADATVRDELVSKITAALTKFRSGAPQGMRIVNQRQFDRLSGYLAA FT AKTDAAADGGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVTVKSLDD FT AIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQVSTAKLPFGGVGASG FT MGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPPYTERAIKVARRLF" FT misc_feature 173994..174017 FT /note="PS00687 Aldehyde dehydrogenases glutamic acid active FT site" FT misc_feature 174078..174113 FT /note="PS00070 Aldehyde dehydrogenases cysteine active FT site" FT CDS 174833..175693 FT /transl_table=11 FT /locus_tag="Rv0148" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /function="UNKNOWN; POSSIBLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0148, (MTCI5.22), len: 286 aa. Probable FT short-chain dehydrogenase (EC 1.-.-.-), similar to others, FT in particular Estradiol 17 beta-dehydrogenases (EC FT 1.1.1.62), e.g. DHB4_MOUSE|P51660 estradiol 17 FT beta-dehydrogenase 4 (735 aa), FASTA scores: opt: 952, E(): FT 0, (52.5% identity in 276 aa overlap). Contains PS00061 FT Short-chain alcohol dehydrogenase family signature. BELONGS FT TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P96825" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P96825" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07054.1" FT /translation="MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDGT FT GAGSAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILR FT DGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLFGNFGQTN FT YGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDILPPEVLEKLTPEFVAPVV FT AYLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQDVAARWAEITDLSGAKI FT AGFKL" FT misc_feature 175283..175369 FT /note="PS00061 Short-chain alcohol dehydrogenase family FT signature" FT CDS 175700..176668 FT /transl_table=11 FT /locus_tag="Rv0149" FT /product="POSSIBLE QUINONE OXIDOREDUCTASE (NADPH:QUINONE FT OXIDOREDUCTASE) (ZETA-CRYSTALLIN)" FT /function="POSSIBLY BINDS NADP AND ACTS THROUGH A FT ONE-ELECTRON TRANSFER PROCESS. QUINONES ARE SUPPOSED TO BE FT THE BEST SUBSTRATES. MAY ACT IN THE DETOXIFICATION OF FT XENOBIOTICS [CATALYTIC ACTIVITY: NADPH + quinone = NADP+ + FT semiquinone]" FT /EC_number="1.6.5.-" FT /note="Rv0149, (MTCI5.23), len: 322 aa. Possible quinone FT oxidoreductase (EC 1.6.5.-), similar to others FT oxidoreductases e.g. Q08257 quinone oxidoreductase (EC FT 1.6.5.5) (329 aa), FASTA scores: opt: 397, E(): 3.2e-18, FT (28.4% identity in 328 aa overlap); SCHCOADH_4 from FT Streptomyces coelicolor. Also similar to many proteins from FT Mycobacterium tuberculosis. Contains PS01162 Quinone FT oxidoreductase / zeta-crystallin signature. BELONG TO THE FT ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE FT OXIDOREDUCTASE SUBFAMILY." FT /db_xref="GOA:P96826" FT /db_xref="HSSP:1IYZ" FT /db_xref="InterPro:IPR002364" FT /db_xref="UniProtKB/TrEMBL:P96826" FT /protein_id="CAB07055.1" FT /translation="MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLL FT LTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHVGERVSAFGVLGGYAEQIAVPVANV FT VRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAKAMQ FT AGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGPTFDD FT ALGVLAIDGKLLLIGFAAGAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGL FT NQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP" FT misc_feature 176117..176170 FT /note="PS01162 Quinone oxidoreductase / zeta-crystallin FT signature" FT CDS complement(176665..176952) FT /transl_table=11 FT /locus_tag="Rv0150c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0150c, (MTCI5.24c), len: 95 aa. Conserved FT hypothetical protein, showing some similarity with FT C-terminus of O53949|Rv1800|MTV049.22 PPE-FAMILY PROTEIN FT from Mycobacterium tuberculosis (655 aa), FASTA score: FT (36.5% identity in 104 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P96827" FT /protein_id="CAB07056.1" FT /translation="MLTLPDDRAPTGLPDPGIEALAHTKIASTISTVVADGYAVVLSTA FT DIANSLLANAIGYPIAASVALVTPAAGANSSCWPADPSQHHRIAESRACA" FT CDS complement(177543..179309) FT /transl_table=11 FT /gene="PE1" FT /locus_tag="Rv0151c" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0151c, (MTCI5.25c), len: 588 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT with N-terminal region similar to others e.g. MTV032_2 FT PE_PGRS family from Mycobacterium tuberculosis (468 aa), FT FASTA scores: opt: 1125, E(): 0, (46.3% identity in 456 aa FT overlap); MTCY493_24 from Mycobacterium tuberculosis FASTA FT score: (42.5% identity in 558 aa overlap). Also similar to FT upstream ORF MTCI5.26c FASTA score: (54.7% identity in 464 FT aa overlap). Also shows similarity to C-terminal part of FT some PPE family proteins e.g. MTV049_21 from Mycobacterium FT tuberculosis FASTA score: (41.5% identity in 591 aa FT overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79G06" FT /protein_id="CAE55245.1" FT /translation="MAPFGFTPKARHNRGVALRSTYRLDGWVMGPVDKEGWGLSYVFAQ FT PSVLAAAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQFQAIS FT AQVAAFHNEFTQRLAAAANAFVNAEATNTSALVQEATAGLFKPTSPPVLPPMFNQNTAI FT IMGGTGSPIPTPSYVNAITTLFIDPVVSNPVVKALVTPEELYPITGVKSLPFQTSVQLG FT LQILDGAIWEQINAGNHVTVFGYSQSAVIASLEMQHLISLGPNAPSPSQLNFILIGNEM FT NPNGGILARIPGLNVTTLGLPFYGATPDNPYPTTTYTLEYDGFADFPRYPLNVLSDINA FT VFGILTVHTTYADLTPAQIASATQLPTQGTTSNTYYIIETEHLPLLAPLRAIPVIGPPL FT AALVEPNLEVIVNLGYGDPRFGYSTSPANVPTPFGLFPDVPASVVADALVAGTQQGVND FT FMVELPAALNTLPQTPMPAFPPYVPTLLPPPPPPQPATLINIADTFASVVSTGYSILLP FT TADLGLAFVTILPAYDLTLFVNQLAAGNLRAAIELPLAATIGLAALGGMIEFIAIVVTL FT ADITQQLQSFSI" FT CDS complement(179319..180896) FT /transl_table=11 FT /gene="PE2" FT /locus_tag="Rv0152c" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0152c, (MTCI5.26c), len: 525 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT similar to ORF downstream Z92770|MTCI5_25 (588 aa), FASTA FT scores: opt: 1492, E(): 0, (54.7% identity in 464 aa FT overlap); and to many other PE family type members." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79G05" FT /protein_id="CAE55246.1" FT /translation="MRCRPPSRNRSAHTARNTRPCSLKSRRFTVRFHQTLAAAANSYAD FT AEAAIASTRQNQLAVPAAAPTPAAAAMIPPFPANLTTLFFGPTGIPLPPPSMLTPPIRC FT RSVRRALQAVFTPEELYPLTGVRSLVLNTSVEEGLTILHDAIMVELATTGNAVTVFGWS FT QSAIIASLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLTFYG FT ATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHTKYLDLTPAQVEGAT FT KLPTSPGYTGVTDYYIIRTENRPLLQPLRAVPVIGDPLADLIQPNLKVIVNLGYGDPNY FT GYSTSYADVRTPFGLWPNVPPQVIADALAAGTQEGILDFTADLQALSAQPLTLPQIQLP FT QPADLVAAVAAAPTPAEVVNTLARIISTNYAVLLPTVDIALALVTTLPLYTTQLFVRQL FT AAGNLINAIGYPLAATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPP FT TTVYRPRQ" FT CDS complement(181155..181985) FT /transl_table=11 FT /gene="ptbB" FT /locus_tag="Rv0153c" FT /standard_name="MPtpB" FT /product="PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB FT (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase)" FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA FT DEPHOSPHORYLATION). CAN DEPHOSPHORYLATED IN VITRO THE FT PHOSPHOTYROSINE RESIDUE OF MYELIN BASIC PROTEIN (MBP) AT pH FT 7.0. COULD BE INVOLVED IN VIRULENCE BY INTERFERING WITH FT PHOSPHOTYROSINE-MEDIATED SIGNALS IN MACROPHAGES [CATALYTIC FT ACTIVITY: Protein tyrosine phosphate + H(2)O = protein FT tyrosine + phosphate]." FT /EC_number="3.1.3.48" FT /note="Rv0153c, (MTCI5.27c), len: 276 aa. ptbB (alternate FT gene name: MPtpB), protein-tyrosine-phosphatase (see FT citation below) (EC 3.1.3.48), showing some similarity to FT several protein-tyrosine phosphatases, polyketide synthase FT and aminotransferase e.g. Q05918|IPHP_NOSCO|IPH FT PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune FT (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E(): FT 0.0096, (26.8% identity in 269 aa overlap); etc. Supposed a FT secreted protein." FT /db_xref="GOA:P96830" FT /db_xref="InterPro:IPR000387" FT /db_xref="PDB:1YWF" FT /db_xref="UniProtKB/TrEMBL:P96830" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07057.1" FT /translation="MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLR FT RLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTN FT DGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAG FT KDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTF FT TKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG" FT CDS complement(181987..183198) FT /transl_table=11 FT /gene="fadE2" FT /locus_tag="Rv0154c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE2" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="1.3.99.-" FT /note="Rv0154c, (MTCI5.28c), len: 403 aa. Probable fadE2, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT C-terminal region of O01590 ACYL-CoA DEHYDROGENASE (974 FT aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in FT 402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase FT (short-chain) (383 aa), FASTA score: (35.0% identity in 306 FT aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:P96831" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:P96831" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07030.1" FT /translation="MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRAAGPADHTAPPII FT EELKTKAKDRGLWNLFLSAESGLTNLEYAPLAEMTGWSMEIAPEALNCAAPDTGNMEIL FT HMFGTEQQRAQWLRPLLDGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWW FT TSGAADPRCKILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHGHCE FT IDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALMVNRVRNRVA FT FGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQHGNKEARHLVAMIKAVAPRVA FT CDVIDRAIQVHGAAGVSDDTPLARLYGWHRAMRIFDGPDEVHLRSIARAELSREKSTFA FT AAVT" FT CDS 183622..184722 FT /transl_table=11 FT /gene="pntAa" FT /locus_tag="Rv0155" FT /standard_name="pntAA" FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) FT PNTAA [FIRST PART; CATALYTIC PART] (PYRIDINE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT ALPHA)" FT /function="THE TRANSHYDROGENATION BETWEEN NADH AND NADP IS FT COUPLED TO RESPIRATION AND ATP HYDROLYSIS AND FUNCTIONS AS FT A PROTON PUMP ACROSS THE MEMBRANE [CATALYTIC ACTIVITY: FT NADPH + NAD+ = NADP+ + NADH]." FT /EC_number="1.6.1.2" FT /note="Rv0155, (MTCI5.29), len: 366 aa. Probable pntAa, FT first part of NAD(P) transhydrogenase subunit alpha (EC FT 1.6.1.2), similar to N-terminus of others e.g. FT PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase FT subunit alpha from Escherichia coli strain K12 (510 aa), FT FASTA scores: opt: 921, E(): 0, (42.1% identity in 361 aa FT overlap); PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT PNTAA (EC 1.6.1.1)." FT /db_xref="GOA:P96832" FT /db_xref="HSSP:1L7D" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:P96832" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07031.1" FT /translation="MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEA FT GAGERALLPDELYTAVGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRNAD FT NSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPMLTT FT AAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGIS FT ASGEGGYARELTDDERAQQQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPG FT SVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPATMPEHASELYSKNITALLDLL FT IKDGRLAPDFDDEVIAQSCVTRGKDS" FT CDS 184723..185055 FT /transl_table=11 FT /gene="pntAb" FT /locus_tag="Rv0156" FT /standard_name="pntAB" FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) FT PNTAB [SECOND PART; INTEGRAL MEMBRANE PROTEIN] (PYRIDINE FT NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE FT NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA)" FT /function="THE TRANSHYDROGENATION BETWEEN NADH AND NADP IS FT COUPLED TO RESPIRATION AND ATP HYDROLYSIS AND FUNCTIONS AS FT A PROTON PUMP ACROSS THE MEMBRANE [CATALYTIC ACTIVITY: FT NADPH + NAD+ = NADP+ + NADH]." FT /note="Rv0156, (MTCI5.30), len: 110 aa. Probable pntAb, FT second part of NAD(P) transhydrogenase subunit alpha, FT integral membrane protein, similar to C-terminus of others FT e.g. Q59764 NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE FT SUBUNIT PNTAB (139 aa), FASTA scores: opt: 247, E(): FT 1.9e-11, (45.5% identity in 88 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P96833" FT /protein_id="CAB07032.1" FT /translation="MYNELLENLAILVLSGFVGFAVISKVPNTLHTPLMSGTNAIHGIV FT VLGALVVFGEIEHPSLVLQVILFVAVVFGTLNVIGGFIVTDRMLGMFKAKKPAVPAKPD FT RDEALR" FT CDS 185052..186479 FT /transl_table=11 FT /gene="pntB" FT /locus_tag="Rv0157" FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) FT PNTB [INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA)" FT /function="THE TRANSHYDROGENATION BETWEEN NADH AND NADP IS FT COUPLED TO RESPIRATION AND ATP HYDROLYSIS AND FUNCTIONS AS FT A PROTON PUMP ACROSS THE MEMBRANE [CATALYTIC ACTIVITY: FT NADPH + NAD+ = NADP+ + NADH]." FT /EC_number="1.6.1.1" FT /note="Rv0157, (MTCI5.31), len: 475 aa. Probable pntB, FT pyridine nucleotide transhydrogenase (nicotinamide FT nucleotide transhydrogenase) subunit beta (EC 1.6.1.1), FT integral membrane protein, similar to others e.g. Q59763 FT PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA from HODOSPIRILLUM RUBRUM FT (464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity FT in 472 aa overlap); FT P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P) FT TRANSHYDROGENASE SUBUNIT BETA from Escherichia coli strains FT K12 and O157:H7 (462 aa)." FT /db_xref="GOA:P96834" FT /db_xref="HSSP:1NM5" FT /db_xref="InterPro:IPR012136" FT /db_xref="UniProtKB/TrEMBL:P96834" FT /protein_id="CAB07033.1" FT /translation="MNLHYLVEILYIISFSLFIYGLMGLTGPKTAVRGNLIAAAGMTIA FT VAATLVMIRHTSQWPLIIAGLVVGVVLGVPPARLTKMTAMPQLVAFFNGVGGGTVALIA FT LSEFIDTTGFSAFQHGESPTVHIVVASLFAAIIGSISFWGSIVAFGKLQEIISGRPIGL FT GKAQQPINLLLLAVAVAAAVVIGLHAHPGSGGVALWWMIGLLVAAGVLGLMVVLPIGGA FT DMPVVISMLNAMTGLSAAAAGLALNNTAMIVAGMIVGASGSILTNLMAKAMNRSIPAIV FT AGGFGGGGVAPSGGGDDKHVKATSAADAAIQMAYANQVIVVPGYGLAVAQAQHAVKDLA FT TLLEDRGVPVKYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFARTDVTIVIG FT ANDVTNPAARNETSSPIYGMPILNVDKSRSVIVLKRSMNSGFAGIDNPLFYADGTTMLF FT GDAKKSVTEVSEELKAL" FT CDS complement(186495..186623) FT /pseudo FT /transl_table=11 FT /locus_tag="Rv0157A" FT /product="HYPOTHETICAL PROTEIN (FRAGMENT)" FT /function="UNKNOWN" FT /note="Rv0157A, len: 42 aa. Hypothetical protein (probably FT pseudogene), showing similarity to C-terminal part (aa FT 186-220) of O53976|Rv1975|MTV051.13 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA FT scores: opt: 173, E(): 3e-06, (62.5% identity in 40 aa FT overlap)." FT /db_xref="PSEUDO:CAE55247.1" FT CDS 186785..187429 FT /transl_table=11 FT /locus_tag="Rv0158" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0158, (MTV032.01), len: 214 aa. Probable FT transcriptional regulator, possibly TetR family, showing FT weak similarity to various transcriptional activators and FT repressors e.g. P32398|YIXD_BACSU|YHGD HYPOTHETICAL FT TRANSCRIPTIONAL REGULATORY PROTEIN from Bacillus subtilis FT (191 aa), FASTA scores: opt:172, E(): 2.4e-05, (23.0% FT identity in 191 aa overlap). Contains helix-turn-helix FT motif at aa 32-53 (Score 1296, +3.60 SD). COULD BELONG TO FT THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse FT score is 0.897." FT /db_xref="GOA:O53641" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:O53641" FT /protein_id="CAA17313.1" FT /translation="MPSDTSPNGLSRREELLAVATKLFAARGYHGTRMDDVADVIGLNK FT ATVYHYYASKSLILFDIYRQAAEGTLAAVHDDPSWTAREALYQYTVRLLTAIASNPERA FT AVYFQEQPYITEWFTSEQVAEVREKEQQVYEHVHGLIDRGIASGEFYECDSHVVALGYI FT GMTLGSYRWLRPSGRRTAKEIAAEFSTALLRGLIRDESIRNQSPLGTRKET" FT CDS complement(187433..188839) FT /transl_table=11 FT /gene="PE3" FT /locus_tag="Rv0159c" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0159c, (MTV032.02c), len: 468 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT similar to many other PE proteins e.g. O06828 from FT Mycobacterium tuberculosis (528 aa), FASTA scores: opt: FT 1163, E(): 0, (45.8% identity in 467 aa overlap). Also FT highly similar to upstream MTV032_3, and to MTCI5_25, FT MTCI5_26, MTV049_ 21, MTCY1A10_26, etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q79G04" FT /protein_id="CAE55248.1" FT /translation="MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAAD FT EVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTAGS FT SGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTPEQW FT WPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMALPPG FT QAPDPSRLAFTLIGNINNPNGGVLERYVGLYLPFLDMSFNGATPPDSPYQTYMYTGQYD FT GYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTHYYMFLT FT QDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPINPIAVAS FT ALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTELSVLSGALG FT SVARLIPPIA" FT CDS complement(188931..190439) FT /transl_table=11 FT /gene="PE4" FT /locus_tag="Rv0160c" FT /product="PE FAMILY PROTEIN" FT /function="UNKNOWN" FT /note="Rv0160c, (MTV032.03c), len: 502 aa. Member of the FT Mycobacterium tuberculosis PE family (see citation below), FT similar to many other PE proteins e.g. Z92770|MTCI5_26c FT from Mycobacterium tuberculosis (525 aa), FASTA scores: FT opt: 816, E(): 0, (41.4% identity in 367 aa overlap); FT C-terminal region of O06801|RV1768|MTCY28.34 from FT Mycobacterium tuberculosis (618 aa), FASTA scores: opt: FT 417, E(): 6.7e-18, (53.5% identity in 142 aa overlap). Also FT highly similar to downstream ORF MTV032_2." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/TrEMBL:Q7DAC9" FT /protein_id="CAE55249.1" FT /translation="MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGD FT EVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHALDT FT INAPIRTLLGRAPLSPNGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVTDIN FT KAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTAVNNQLALDNKV FT VAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDV FT PFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPELMATQV FT DNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYA FT DYGPGGNYADIPTPAGLFSIPNPFAVTYYLIKGSLQAPYGAIVEIGVEAGLIGPEWFPD FT SYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILHLIPPPVFT" FT CDS 190607..191956 FT /transl_table=11 FT /locus_tag="Rv0161" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0161, (MTCI28.01, MTV032.04), len 449 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to hypothetical FT proteins and various oxidoreductases e.g. AIP2_YEAST|P46681 FT actin interacting protein 2 (530 aa), FASTA scores: opt: FT 356, E (): 0, (33.3% identity in 357 aa overlap); FT DLD1_YEAST|P32891 d-lactate dehydrogenase (cytochrome) (587 FT aa), FASTA scores: opt: 311, E(): 2.5e-20, (27.9% identity FT in 366 aa overlap). Also similar to other Mycobacteria FT proteins e.g. MTCY339.30c from Mycobacterium tuberculosis FT FASTA score: (29.4% identity in 357 aa overlap); FT MLCL622.30c from Mycobacterium tuberculosis (449 aa)." FT /db_xref="GOA:O07406" FT /db_xref="InterPro:IPR006094" FT /db_xref="UniProtKB/TrEMBL:O07406" FT /protein_id="CAB09760.1" FT /translation="MLTSLVSAVGSHHVTTDPDVLAGRSVDHTGRYRGRASALVRPGSA FT EEVAEVLRVCRDAGAYVTVQGGRTSLVAGTVPEHDDVLLSTERLCVVSDVDTVERRIEI FT GAGVTLAAVQHAASTAGLVFGVDLSARDTATVGGMASTNAGGLRTVRYGNMGEQVVGLD FT VALPDGTVLRRHSRVRRDNTGYDLPALFVGAEGTLGVITALDLRLHPTPSHRVTAVCGF FT AELAALVDAGRMFRDVEGIAALELIDGRAAALTREHLGVRPPVEADWLLLVELAADHDQ FT TDRLADLLGGARMCGEPAVGVDAAAQQRLWRTRESLAEVLGVYGPPLKFDVSLPLSAIS FT GFARDAVALVHRHVPDSPEALPLLFGHIGEGNLHLNVLRCPPDREPALYAKMMGLIAEC FT GGNVSSEHGVGSRKRAYLGMSRQANDVAAMRRVKAALDPTGYLNAAVLFD" FT CDS complement(191984..193135) FT /transl_table=11 FT /gene="adhE1" FT /locus_tag="Rv0162c" FT /product="PROBABLE ZINC-TYPE ALCOHOL DEHYDROGENASE (E FT SUBUNIT) ADHE" FT /function="DEHYDROGENESES A ALCOHOL (OXIDO-REDUCTION) FT [CATALYTIC ACTIVITY: An alcohol + NAD+ = an aldehyde or FT ketone + NADH]." FT /EC_number="1.1.1.1" FT /note="Rv0162c, (MTCI28.02c), len: 383 aa. Probable adhE1, FT zinc-type alcohol dehydrogenase (EC 1.1.1.1), similar to FT others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha FT chain (374 aa), FASTA scores: opt: 619, E(): 0, (34.7% FT identity in 363 aa overlap). Also similar to other alcohol FT dehydrogenases from Mycobacterium tuberculosis e.g. FT MTCY369.06c FASTA score: (34.0% identity in 365 aa FT overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa FT overlap). Contains PS00059 Zinc-contain ingalcohol FT dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING FT ALCOHOL DEHYDROGENASE FAMILY, CLASS-I SUBFAMILY. COFACTOR: FT ZINC." FT /db_xref="GOA:Q7DAC8" FT /db_xref="HSSP:1AXE" FT /db_xref="InterPro:IPR013154" FT /db_xref="UniProtKB/TrEMBL:Q7DAC8" FT /protein_id="CAE55250.1" FT /translation="MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPP FT DRGEVLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAVGQRVV FT LVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRGGRPVYHHLGVSGFATH FT VVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQSVAVVGLGGVGMAAV FT LTALTYTDVRVVAVDQLPEKLSAAKALGAHEIYTPQQATAGGVKAAVVVEAVGHPAALH FT TAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSLW FT QSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL" FT misc_feature complement(192854..192898) FT /note="PS00059 Zinc-containing alcohol dehydrogenases FT signature" FT CDS 193117..193572 FT /transl_table=11 FT /locus_tag="Rv0163" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0163, (MTCI28.03), len: 151 aa. Conserved FT hypothetical protein, similar to others e.g. Q44017 FT HYPOTHETICAL 16.6 KDA PROTEIN IN GBD 5'REGION (ORF6)from FT Alcaligenes eutrophus (145 aa), FASTA scores: opt: 155, FT E(): 0.0002, (26.6% identity in 139 aa overlap). Also weak FT similary with MTV008.31c|Rv2475c|B70867 from Mycobacterium FT tuberculosis (138 aa)." FT /db_xref="InterPro:IPR006683" FT /db_xref="UniProtKB/TrEMBL:O07408" FT /protein_id="CAB09758.1" FT /translation="MAALPAPEKLLRSDFPVLWPVGTRWADNDMFGHLNNAVYYQLFDT FT AINAWINTSTGVDPLAMPVLGIVAESGCRYFSELRFPESLMVGLAVTRLGRSSVTYRLG FT VFKEPDDAGVITALGHWVHVYVDRTSRRPVPIPEAIRSLLSTACVSG" FT CDS 193626..194111 FT /transl_table=11 FT /gene="TB18.5" FT /locus_tag="Rv0164" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB18.5" FT /function="UNKNOWN" FT /note="Rv0164, (MTCI28.04), len: 161 aa. TB18.5, conserved FT hypothetical protein, equivalent to CAB08818.1|Z95398 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (156 aa) FT FASTA scores: opt: 762, E(): 0, (76.3% identity in 152 aa FT overlap). Some similarity to Rv2185c, Rv0854, Rv0857 from FT Mycobacterium tuberculosis. Alternative start codon has FT been suggested. 3' part corrected since first submission FT (-24 aa)." FT /db_xref="InterPro:IPR005031" FT /db_xref="UniProtKB/TrEMBL:Q8VKQ8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55251.1" FT /translation="MTAISCSPRPRYASRMPVLSKTVEVTADAASIMAIVADIERYPEW FT NEGVKGAWVLARYDDGRPSQVRLDTAVQGIEGTYIHAVYYPGENQIQTVMQQGELFAKQ FT EQLFSVVATGAASLLTVDMDVQVTMPVPEPMVKMLLNNVLEHLAENLKQRAEQLAAS" FT CDS complement(194144..194938) FT /transl_table=11 FT /locus_tag="Rv0165c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0165c, (MTCI28.05c), len: 264 aa. Possible FT transcriptional regulator, GntR family, showing some FT similarity to several e.g. NTRA_CHELE|P54988 nta operon FT transcriptional regulator (231 aa), FASTA scores: opt: 154, FT E(): 0.00058, (32.0% identity in 125 aa overlap); FT P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL FT REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU FT GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). FT Also similar to Rv0043c from Mycobacterium tuberculosis. FT SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL FT REGULATORS." FT /db_xref="GOA:Q79G00" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q79G00" FT /protein_id="CAE55252.1" FT /translation="MIKHDVVWVTLWPERPNNKPPPSPRQVPGNPGPTLKVLASHVNAP FT LSAKPRSQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREAL FT LKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQATIAQELATSATAHITDVEIDELDR FT INNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLAWFLLNAARYMGAGVRGRPAMG FT RGRGEQSSAADRRAAPPRHSRRNRAHRLAVHRWGTQADGGPG" FT CDS 194993..196657 FT /transl_table=11 FT /gene="fadD5" FT /locus_tag="Rv0166" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD5 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv0166, (MTCI28.06), len: 554 aa. Probable fadD5, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many eg FT LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 FT aa), FASTA scores: opt: 612, E(): 0, (29.4% identity in 534 FT aa overlap). Also similar to many other fatty-acid-CoA FT ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c FT FASTA score: (35.3% identity in 487 aa overlap), MTV013_10, FT MTY25D10_30, etc. Contains PS00455 putative AMP-binding FT domain signature." FT /db_xref="GOA:O07411" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:O07411" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09749.1" FT /translation="MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPAL FT RFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAANMIGAIAV FT PLNFRLTPTEIAVLVEDCVAHVMLTEAALAPVAIGVRNIQPLLSVIVVAGGSSQDSVFG FT YEDLLNEAGDVHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGAN FT INSDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFLV FT PAQWQAVCTEQQARPRDLRLRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSPV FT TCMLLGEDAIAKRGSVGRVIPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPE FT ATAEAFAGGWFHSGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAE FT VAVIGRADEKWGEVPIAVAAVTNDDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPA FT GKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL" FT misc_feature 195554..195589 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS 196861..197658 FT /transl_table=11 FT /gene="yrbE1A" FT /locus_tag="Rv0167" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE1A" FT /function="UNKNOWN" FT /note="Rv0167, (MTCI28.07), len: 265 aa. yrbE1A, FT hypothetical unknown integral membrane protein, part of FT mce1 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); FT O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly FT similar or similar to conserved hypothetical integral FT membrane proteins of yrbEA type, e.g. NP_302654.1|NC_002677 FT conserved membrane protein from Mycobacterium leprae (267 FT aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from FT Haemophilus influenzae (261 aa), FASTA scores: opt: 328, FT E(): 1.8e-15, (26.6% identity in 244 aa overlap); etc." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:O07412" FT /protein_id="CAB09750.1" FT /translation="MTTSTTLGGYVRDQLQTPLTLVGGFFRMCVLTGKALFRWPFQWRE FT FILQCWFIMRVGFLPTIMVSIPLTVLLIFTLNILLAQFGAADISGSGAAIGAVTQLGPL FT TTVLVVAGAGSTAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVLASMLVATLLNGL FT VITVGLVGGFLFGVYLQNVSGGAYLATLTLITGLPEVVIATIKAATFGLIAGLVGCYRG FT LTVRGGSKGLGTAVNETVVLCVIALFAVNVILTTIGVRFGTGR" FT CDS 197660..198529 FT /transl_table=11 FT /gene="yrbE1B" FT /locus_tag="Rv0168" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE1B" FT /function="UNKNOWN" FT /note="Rv0168, (MTCI28.08), len: 289 aa. yrbE1B, FT hypothetical unknown integral membrane protein, part of FT mce1 operon and member of YrbE family (see citations FT below), highly similar to Mycobacterium tuberculosis FT proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); FT O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly FT similar to conserved hypothetical integral membrane FT proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 FT conserved membrane protein from Mycobacterium leprae (289 FT aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from FT Haemophilus influenzae (261 aa), FASTA scores: opt: 223, FT E(): 7.6e-07, (23.7% identity in 257 aa overlap); etc." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:O07413" FT /protein_id="CAB09751.1" FT /translation="MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIGQ FT IAHALRYYRKETLRLIAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGNIG FT VEAFTGFFAALINVRIAGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIKSIS FT FLASTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPDDVFW FT SFLEALIITAIVMVSHCYYGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAALALYGV FT DPNFNLTV" FT CDS 198534..199898 FT /transl_table=11 FT /gene="mce1A" FT /locus_tag="Rv0169" FT /standard_name="mce1" FT /product="MCE-FAMILY PROTEIN MCE1A" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION (ENTRY AND SURVIVAL INSIDE MACROPHAGES)." FT /note="Rv0169, (MTCI28.09), len: 454 aa. mce1A; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A FT (404 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. FT Also highly similar to others e.g. FT AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry FT protein from Mycobacterium bovis BCG (454 aa); FT NP_302656.1|NC_002677 putative cell invasion protein from FT Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene FT product from Mycobacterium avium (88 aa) (similarity on FT C-terminus); CAC12798.1|AL445327 putative secreted protein FT from Streptomyces coelicolor (418 aa); etc. Note that FT equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901 FT Mcep protein from Mycobacterium tuberculosis (432 aa). FT Contains a very hydrophobic region around residues 20-35. FT Note that previously known as mce1." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:Q79FZ9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAE55253.1" FT /translation="MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKT FT QLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIHLIPA FT NVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVTTEINTLFQTLTSIAEKV FT DPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDLNSRMPQSRHDIQQLAALGDVYA FT DAAPDLFDFLDSSVTTARTINAQQAELDSALLAAAGFGNTTADVFDRGGPYLQRGVADL FT VPTATLLDTYSPELFCTIRNFYDADPLAKAASGGGNGYSLRTNSEILSGIGISLLSPLA FT LATNGAAIGIGLVAGLIAPPLAVAANLAGALPGIVGGAPNPYTYPENLPRVNARGGPGG FT APGCWQPITRDLWPAPYLVMDTGASLAPYNHMEVGSPYAVEYVWGRQVGDNTINP" FT CDS 199895..200935 FT /transl_table=11 FT /gene="mce1B" FT /locus_tag="Rv0170" FT /standard_name="mceD" FT /product="MCE-FAMILY PROTEIN MCE1B" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0170, (MTCI28.10), len: 346 aa. mce1B (alternate FT gene name: mceD); belongs to 24-membered Mycobacterium FT tuberculosis Mce protein family (see citations below), FT highly similar to Mycobacterium tuberculosis proteins FT O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); FT O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly FT similar to others e.g. NP_302657.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (346 aa); FT CAC12797.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (354 aa); etc. Contains hydrophobic FT region in N-terminal 30 residues. In Escherichia coli, FT N-terminal part is functional and directs export of a FT leaderless beta-lactamase into the periplasm (see Chubb et FT al., 1998)." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O07414" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09753.1" FT /translation="MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSN FT VSGLRQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYSDLIG FT NRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVFRALDPAKVNNIAN FT ALITVFQGQGGTINDILDQTAQLTSQIAERDQAIGEVVKNLNIVLDTTVKHRKEFDETV FT NNLENLITGLRNHSDQLAGGLAHISNGAGTVADLLAENRTLVRKAVSYLDAIQQPVIDQ FT RVELDDLLHKTPTALTALGRANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVKLFSQPT FT GRCTPQ" FT CDS 200932..202479 FT /transl_table=11 FT /gene="mce1C" FT /locus_tag="Rv0171" FT /product="MCE-FAMILY PROTEIN MCE1C" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0171, (MTCI28.11), len: 515 aa. mce1C; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481 FT aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also FT highly similar to others e.g. NP_302658.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (519 FT aa); CAC12796.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (351 aa); etc. Weakly similar to FT downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA FT score: (24.6% identity in 552 aa overlap). Contains FT possible signal sequence and highly proline-rich FT C-terminus." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:O07415" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09754.1" FT /translation="MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQ FT FTDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNTIGTESRLAIRTDTILG FT RKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKAASGWDIETVKRSLNVLSE FT TVDQTYPHLSAALDGVAKFSDTIGKRDEQITHLLAQANQVASILGDRSEQVDRLLVNAK FT TLIAAFNERGRAVDALLGNISAFSAQVQNLINDNPNLNHVLEQLRILTDLLVDRKEDLA FT ETLTILGRFSASFGETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAG FT LPAYRWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADGLPRPWDPL FT PCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAPGLPIAGRPGEVPPNVPGTPVPIPQ FT EAPPGARTLPLGPAPGPAPPPAAPGPPAPPGPGPQLPAPFINPGGTGGSGVTGGSEN" FT CDS 202476..204068 FT /transl_table=11 FT /gene="mce1D" FT /locus_tag="Rv0172" FT /product="MCE-FAMILY PROTEIN MCE1D" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0172, mce1D (MTCI28.12), len: 530 aa. mce1D; FT belongs to 24-membered Mycobacterium tuberculosis Mce FT protein family (see citations below), highly similar to FT Mycobacterium tuberculosis proteins FT O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); FT O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly FT similar to others e.g. NP_302659.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (531 aa); FT CAC12795.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (337 aa); etc. Hydrophobic region FT at N-terminus." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:O07416" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09755.1" FT /translation="MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLT FT NNTVVAYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPANASAV FT ILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRDSVSHIIDELGPTP FT EQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALNALNEGRGDFFAVVRSLALFVNA FT LHQDDQQFVALNKNLAEFTDRLTHSDADLSNAIQQFDSLLAVARPFFAKNREVLTHDVN FT NLATVTTTLLQPDPLDGLETVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFANPMEFI FT CSSIQAGSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSEPRL FT QPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLTPESLAELMG FT GPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPPPPPGPDVIPGPVPPTPAP FT VGAPLPAEAGGGQ" FT CDS 204065..205237 FT /transl_table=11 FT /gene="lprK" FT /locus_tag="Rv0173" FT /standard_name="mce1E" FT /product="POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY FT LIPOPROTEIN MCE1E)" FT /function="UNKNOWN, BUT THOUGHT TO BE INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0173, (MTCI28.13), len: 390 aa. Possible lprK FT (alternate gene name: mce1E), lipoprotein which belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), highly similar to Mycobacterium FT tuberculosis proteins O07785|LPRL|Rv0593|MTCY19H5.29|mce2E FT (402 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. FT Also highly similar to others e.g. NP_302660.1|NC_002677 FT putative lipoprotein from Mycobacterium leprae (392 aa); FT CAC12794.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (413 aa); etc. Contains PS00013 FT prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:O07417" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09756.1" FT /translation="MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGP FT GTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLKKDVTLPK FT NATAKIGQTSLLGSQHVELAAPPDPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLR FT GGGLVNLEGIQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAY FT VGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQ FT ALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAF FT LTGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC" FT misc_feature 204125..204157 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 205231..206778 FT /transl_table=11 FT /gene="mce1F" FT /locus_tag="Rv0174" FT /product="MCE-FAMILY PROTEIN MCE1F" FT /function="UNKNOWN, BUT THOUGHT INVOLVED IN HOST CELL FT INVASION." FT /note="Rv0174, (MTCI28.14), len: 515 aa. mce1F; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below), similar to Mycobacterium FT tuberculosis proteins O07784|Rv0594|MTCY19H5.28c|mce2F (516 FT aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also FT highly similar to others e.g. NP_302661.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (516 FT aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from FT Mycobacterium avium (80 aa) (similarity on C-terminus); FT CAC12793.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (433 aa); etc. Has hydrophobic FT stretch, possibly a signal peptide at the N-terminus." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:O07418" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09741.1" FT /translation="MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKAD FT LPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVHSVSAV FT GEQYIDLVSTGAPGKYFSSGQTITKGTVPSEIGPALDNSNRGLAALPTEKIGLLLDETA FT QAVGGLGPALQRLVDSTQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKL FT NNLAAQTATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAG FT VEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSPADTSPR FT PLPSGTYCKIPQDAQLQVRGARNIPCVDVLGKRAATPKECRSKDPYVPLGTNPWFGDPN FT QILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQ FT CNGQQPNPCVYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS" FT repeat_region 206812..206850 FT /note="39 bp direct repeat 1, FT AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG" FT CDS 206814..207455 FT /transl_table=11 FT /locus_tag="Rv0175" FT /product="PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv0175, (MTCI28.15), len: 213 aa. Probable conserved FT Mce-associated membrane protein, equivalent, but longer in FT N-terminus, to CAC32127.1|AL583926 possible membrane FT protein from Mycobacterium leprae (182 aa). Also similar to FT mce-associated proteins from Mycobacterium tuberculosis FT e.g. Rv1363c, Rv0177, Rv1973, etc. Contains two 12 residue FT direct repeats at N-terminus." FT /db_xref="UniProtKB/TrEMBL:O07419" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09742.1" FT /translation="MKAADSAESDAGADQTGPQVKAADSAESDAGELGEDACPEQALVE FT RRPSRLRRGWLVGIAATLLALAGGLGAAGYFALRSHQESQSIAREDLAAIEAAKDCVAA FT TQAPDAGAMSASMQKIIECGTGDFGAQASLYTSMLVEAYQAASVHVQVTDMRAAVERNN FT NDGSVDVLVALRVKVSNTDSDAHEVGYRLRVRMALDEGRYKIAKLDQVTK" FT repeat_region 206869..206907 FT /note="39 bp direct repeat 2, FT AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG" FT CDS 207452..208420 FT /transl_table=11 FT /locus_tag="Rv0176" FT /product="PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv0176, (MTCI28.16), len: 322 aa. Probable conserved FT Mce-associated transmembrane protein. Contains short region FT of similarity to PRA_MYCLE|P41484 proline-rich antigen (36 FT kDa antigen) from Mycobacterium leprae (249 aa) (outside FT the proline-rich region), FASTA scores: opt: 165, E(): FT 2.9e-05, (40.0% identity in 65 aa overlap). Also similar to FT mce-associated proteins from Mycobacterium tuberculosis FT e.g. Rv1363c, Rv0177, Rv3493c, etc." FT /db_xref="GOA:O07420" FT /db_xref="InterPro:IPR010432" FT /db_xref="UniProtKB/TrEMBL:O07420" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09743.1" FT /translation="MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATMA FT LTALTVPPGSAWRWLCACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGSAI FT GPWRLLVRDLAHLVDTLSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVIRRL FT TAAVALAAAGACASATAVGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPETVQRD FT FERARSLATDRYRPQLSIQQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFMQGERG FT TPPNQRYIQSTVRAIFQKSRGQWRLDDLAVVMKPRQPTGEK" FT CDS 208417..208971 FT /transl_table=11 FT /locus_tag="Rv0177" FT /product="PROBABLE CONSERVED MCE ASSOCIATED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0177, (MTCI28.17), len: 184 aa. Probable conserved FT Mce-associated protein, equivalent to CAC32129.1|AL583926 FT conserved membrane protein from Mycobacterium leprae (184 FT aa). Also similar to mce-associated proteins from FT Mycobacterium tuberculosis e.g. Rv1363c, Rv1973, Rv3493c, FT etc." FT /db_xref="UniProtKB/TrEMBL:O07421" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09744.1" FT /translation="MSPRRKFEPGEGALLAPQSIEPSRRWGLPLALTASAVVMAAAISA FT CALMRISHESHQRAAHKDIVMLSDVRSFMTMFTSPDPFHANEYAERVLSHATGDFAKQY FT HERANDILIRISGVEPTTGTVLDAGVQRWNEDGSANVLVVTQITSKSADGKRVVSNANR FT WLVTAKQEGNEWKISSLLPVI" FT CDS 208938..209672 FT /transl_table=11 FT /locus_tag="Rv0178" FT /product="PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE FT PROTEIN" FT /function="UNKNOWN" FT /note="Rv0178, (MTCI28.18), len: 244 aa. Probable conserved FT Mce-associated membrane protein, highly similar in FT C-terminus to CAC32130.1|AL583926 putative secreted protein FT from Mycobacterium leprae (184 aa). Also similar to FT mce-associated proteins from Mycobacterium tuberculosis FT e.g. Rv1363c, Rv0177, Rv1973, etc. Note that there is a 10 FT aa overlap with the upstream ORF." FT /db_xref="UniProtKB/TrEMBL:O07422" FT /protein_id="CAB09745.1" FT /translation="MEDQQSASGDLTQKSVANGESTDTASAATEGHRGEIDAAGEPDER FT GAAVADSQADEDDSAATAARGGKTRARRSRGRRLAITVGVAAALFVGSAAFAGATVEPY FT LSERAVVATKLMVARTAANAITTLWTYTPENMDTLADRAANYLSGDFAAQYRRFVDQIA FT AANKQAKITNDTEVTGAAVESLSGRDAVAIVYTNTTTTSPVTKNIPALKYLSYRLFMKR FT YDARWLVTRMTTITSLDLTPQV" FT CDS complement(209703..210812) FT /transl_table=11 FT /gene="lprO" FT /locus_tag="Rv0179c" FT /product="POSSIBLE LIPOPROTEIN LPRO" FT /function="UNKNOWN" FT /note="Rv0179c, (MTCI28.19c), len: 369 aa. Possible lprO, FT lipoprotein (visibly not conserved). Contains possible FT N-terminal signal sequence and PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="UniProtKB/TrEMBL:O07423" FT /protein_id="CAB09746.1" FT /translation="MWIRAERVAVLTPTASLRRLTACYAALAVCAALACTTGQPAARAA FT DGREMLAQAIATTRGSYLVYNFGGGHPMPLLNAGGHWYEMNNGGHLMIIKNASQRLSPH FT LLVDTHTGDQARCEHNPGARTGEGLWQASEIYPPLKAWQRMGRPTIAVNANFFDVRGQK FT GGSWRSTGCSSPLGAYVDNTRGQGRANQAVTGTVAYAGKQGLSGGNELWSSLTTMILPV FT GGAPYVLRPKSRQDYDLATPVIEDLLNKNARFVAVAGIGLLSPGNTGQLHDGGPSAART FT ALAYAKQKDEMYIFQGGNYTPDNIQDLFRGLGSDTAILLDGGGSSAIVLRRDTGGMWAG FT AGSPKGSCDTRQVLCDSHERALPSWLAFN" FT misc_feature complement(210708..210740) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(210892..212250) FT /transl_table=11 FT /locus_tag="Rv0180c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0180c, (MTCI28.20c), len: 452 aa. Probable FT conserved transmembrane protein, equivalent to FT CAC32132.1|AL583926 probable conserved membrane protein FT from Mycobacterium leprae (465 aa). Shows some similarity FT with others membrane proteins e.g. AL096849|SCI11_29 from FT Streptomyces coelicolor (354 aa), FASTA scores: opt: 190, FT E(): 0.00067, (25.9% identity in 409 aa overlap)." FT /db_xref="GOA:O07424" FT /db_xref="UniProtKB/TrEMBL:O07424" FT /protein_id="CAB09747.1" FT /translation="MSQAQPRPAAPNPKRNVKAIRTVRFWMAPIATTLALMSALAALYL FT GGILNPMTNLRHFPIALVNEDAGPAGQQIVDGLVSGLDKNKFDIRVVSPDEARRLLDTA FT AVYGSALIPPTFSSQLRDFGASAVTPTRTDRPAITISTNPRAGTLAASIAGQTLTRALT FT VVNGKVGERLTAEVAAQTGGVALAGAAAAGLASPIDVKSTAYNPLPNGTGNGLSAFYYA FT LLLLLAGFTGSIVVSTLVDSMLGYVPAEFGPVYRFAEQVNISRFRTLLVKWAVMVVLAL FT LTSGVYLAIAHGLGMPIPLGWQVWLYGVFAIIAVGVTSSSLIAVLGSMGLLVSMLIFVI FT LGLPSAGATVPLEAVPAFFRWLAQFEPMHQVFLGVRSLLYLNGNADAGLSQALTMTSIG FT LIIGLLLGGFITHLYDRSSFHRIPGAVEMAIAVEHQAQYQARQSARESSSEQP" FT CDS complement(212277..213011) FT /transl_table=11 FT /locus_tag="Rv0181c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0181c, (MTCI28.21c), len: 244 aa. Conserved FT hypothetical protein, highly similar to other hypothetical FT proteins e.g. YHHW_ECOLI|P46852 hypothetical 26.3 kd FT protein from Escherichia coli (231 aa), FASTA scores: opt: FT 479, E(): 1.2e-29, (37.3% identity in 233 aa overlap); FT P73623|SLL1773 HYPOTHETICAL 25.7 kDa PROTEIN from FT Synechocystis sp. strain PCC 6803 (232 aa), FASTA score: FT (39.1% identity in 233 aa overlap)." FT /db_xref="InterPro:IPR003829" FT /db_xref="UniProtKB/Swiss-Prot:P65724" FT /protein_id="CAB09748.1" FT /translation="MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLV FT NNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGILH FT SEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAALTL FT HNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGL FT TANEPSEVLIWEMHAKLGDSAT" FT CDS complement(213028..214140) FT /transl_table=11 FT /gene="sigG" FT /locus_tag="Rv0182c" FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGG (RNA POLYMERASE ECF TYPE SIGMA FACTOR)" FT /function="THE SIGMA FACTOR IS AN INITIATION FACTOR THAT FT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC FT INITIATION SITES AND THEN IS RELEASED." FT /note="Rv0182c, (MTCI28.22c), len: 370 aa (start site FT uncertain; first of several possibles was chosen, but note FT that this overlaps the upstream ORF). Probable sigG, FT alternative RNA polymerase sigma subunit (see citations FT below), similar to many e.g. Q45585|SIGW_BACSU RNA FT POLYMERASE SIGMA FACTOR from Bacillus subtilis (187 aa). FT Also similar to nine other ECF sigma factors from FT Mycobacterium tuberculosis e.g. Rv1221, Rv0735, etc. FT Contains PS01063 Sigma-70 factors ECF subfamily signature FT and probable helix-turn helix motif from aa 205-226 (Score FT 1181, +3.21 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF FT SUBFAMILY." FT /db_xref="GOA:O07426" FT /db_xref="HSSP:1H3L" FT /db_xref="InterPro:IPR014305" FT /db_xref="UniProtKB/TrEMBL:O07426" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09733.1" FT /translation="MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAEN FT SGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFAGK FT SSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPDVTD FT DPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTSTVAVN FT SLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTAEAIWE FT MPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVHLPFQLH FT VLDMAADRVSHVVAFLDTTLFPKFGLPDSL" FT misc_feature complement(213856..213894) FT /note="PS01063 Sigma-70 factors ECF subfamily signature" FT CDS 214088..214927 FT /transl_table=11 FT /locus_tag="Rv0183" FT /product="POSSIBLE LYSOPHOSPHOLIPASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="3.1.-.-" FT /note="Rv0183, (MTCI28.23), len: 279 aa. Possible FT lysophospholipase (EC 3.1.-.-), similar to several FT (especially eukaryotic enzymes, weaker with Escherichia FT coli), e.g. U67963|HSU67963_1 Human lysophospholipase FT homolog from Homo sapiens (313 aa), FASTA scores: opt: 569, FT E(): 2.6e-29, (37.1% identity in 259 aa overlap); FT P07000|PLDB_ECOLI LYSOPHOSPHOLIPASE L2 from Escherichia FT coli (165 aa), FASTA scores: opt: 219, E(): 0.00012. Start FT changed based on similarity to AE001997_8 from Deinococcus FT radiodurans (282 aa), FASTA scores: opt: 510, E(): 1.4e-25, FT (34.8% identity in 282 aa overlap). Also shows some FT similarity to epoxide hydrolases from Mycobacterium FT tuberculosis e.g. Rv1938 FASTA score: (30.7% identity in FT 114 aa overlap); and FT O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa)." FT /db_xref="GOA:O07427" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:O07427" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09734.2" FT /translation="MTTTRTERNFAGIGDVRIVYDVWTPDTAPQAVVVLAHGLGEHARR FT YDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRDISEYTADFDTLVGIATREYPGCKR FT IVLGHSMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPGLPV FT QELDFTAISRDPEVVQAYNTDPLVHHGRVPAGIGRALLQVGETMPRRAPALTAPLLVLH FT GTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVFNEPERNQVLDDVVAWLTERL" FT CDS 214969..215718 FT /transl_table=11 FT /locus_tag="Rv0184" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0184, (MTCI28.24), len: 249 aa. Conserved FT hypothetical protein, equivalent to CAC32136.1|AL583926 FT conserved hypothetical protein from Mycobacterium lepra FT (249 aa); and C-terminus highly similar to FT CAB08793.1|Z95398 conserved hypothetical protein from FT Mycobacterium leprae (145 aa), FASTA scores: E(): 0, (75.2 FT identity in 145 aa overlap). Also similar to FT 049841|SCE9_39|T36358 hypothetical protein from FT Streptomyces coelicolor (418 aa), FASTA scores: opt: 231, FT E(): 8.1e-08, (30.4% identity in 270 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:O07428" FT /protein_id="CAB09735.1" FT /translation="MTNDKMLARIAALLRQAEGTDNPHEADAFMSTAQRLATAASIDLA FT VARSHAGNRSPAQAPTQRTITIGAAGTRGLRTYVQLFVLIAAANDVRCDVASNSTFVYA FT YGFAEDIDTSHALYASLVVQMVRASDAYLASGAHRPTPTITARLNFQLAFGARVGQRLA FT DAREQTRQEATKDRDRPPGTAIALRDKDIELHEYYRRSSKARGAWRASRATAGYSSAAR FT RAGDRAGRQARLGNNPELPGARAALGR" FT CDS 215715..216224 FT /transl_table=11 FT /locus_tag="Rv0185" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN; PROBABLY INVOLVED IN A CELLULAR FT METABOLISM." FT /note="Rv0185, (MTCI28.25a), len: 169 aa. Conserved FT hypothetical protein, equivalent to FT CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 FT aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in 165 FT aa overlap). Contains PS00142 Neutral zinc FT metallopeptidases, zinc-binding region signature." FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:O07429" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09736.1" FT /translation="MIGADVPRDSQRARVYAAEAFVRTLFDRVTAHGSPTVEFFGTQLT FT LPPEGRFGSVASVQRYVDDVLALPAVGQNWPTVSPVRVRARRAATAAHYENHGGTGTIA FT VPDRHTAGWAMRELVVLHEVAHHLCQVPPPHGPEFVATVCTLTELVMGPEVGHVFRVVY FT AQEGVR" FT misc_feature 216069..216098 FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS 216269..218344 FT /transl_table=11 FT /gene="bglS" FT /locus_tag="Rv0186" FT /product="PROBABLE BETA-GLUCOSIDASE BGLS (GENTIOBIASE) FT (CELLOBIASE) (BETA-D-GLUCOSIDE GLUCOHYDROLASE)" FT /function="POSSIBLY INVOLVED IN DEGRADATION [CATALYTIC FT ACTIVITY: Hydrolysis of terminal, non-reducing FT beta-D-glucose residues with release of beta-D-glucose]." FT /EC_number="3.2.1.21" FT /note="Rv0186, (MTCI28.25b), len: 691 aa. Probable bglS, FT beta-glucosidase (EC 3.2.1.21), highly similar to many e.g. FT BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium FT tumefaciens (818 aa), FASTA scores: opt: 643, E(): 0, FT (32.5% identity in 842 aa overlap). SEEMS TO BELONG TO FT FAMILY 3 OF GLYCOSYL HYDROLASES." FT /db_xref="GOA:O07430" FT /db_xref="InterPro:IPR002772" FT /db_xref="UniProtKB/TrEMBL:O07430" FT /protein_id="CAB09737.1" FT /translation="MTDDERFSLLVGLTGASDLWPVRDERIPQGVPMCAGYVPGIPRLG FT VPALLMSDAGLGVTNPGYRPGDTATALPAGLALAASFNPVLARSSGKAIGREARSRGFN FT VQLAGAINLARDPRNGRNFEYLSEDPLLSATMAAESIIGIQQQGVIATTKHFSLNCNET FT NRHWLDAVIDPDAHRESDLLAFEIVIERSQPGAVMAAYNKVNGDYAAGNDHLLNDVLKG FT AWGYRGWVMSDWGGTPSWECALAGLDQECGAQIDAVLWQSEAFTDRLRAAYADGNLPKG FT RLSDMVRRILRSMFAVGIDRWKPAPAPDMNAHNEIAAQMARQGIVLLQNRGLLPLAPES FT AGRIAVIGGYAHLGVPAGYGSSAVTPPGGYAGVIPIGGSGLAAGLRNLYLLPSSPLSEL FT RKRLPNAQFEFDPGINPAEAVLAARRADIAIVFAIRAEGEGFDSADLSLPWGQDALIAA FT VASANANTVVVLETGNPVTMPWRDSVNAIMQAWYPGQAGGQAVAEIVTGQVNPSGRLPI FT TFPVDLGQTPRSQPPELGAPWGTSTTIHYTEGADVGYRWFASTNQTPMFAFGHGLSYTS FT FEYRDLVVTGGHTVHASFSVTNTGDRSGADVPQLYMIAAPGESRLRLLGFERVELEPGQ FT TRRVRIEADPRLLARYDGEARSWRIEPGGYTVAVGASAVALKLAAKVKLAGRGFGR" FT CDS 218705..219367 FT /transl_table=11 FT /locus_tag="Rv0187" FT /product="PROBABLE O-METHYLTRANSFERASE" FT /function="THOUGHT TO BE INVOLVED IN TRANSFER OF METHYL FT GROUP." FT /EC_number="2.1.1.-" FT /note="Rv0187, (MTCI28.26), len: 220 aa. Probable FT O-methyltransferase (EC 2.1.1.-), similar to many e.g. FT AB93458.1|AL357591 putative O-methyltransferase from FT Streptomyces coelicolor (223 aa); MDMC_STRMY|Q00719 FT O-methyltransferase from Streptomyces mycarofaciens (221 FT aa), FASTA scores: opt: 327, E(): 2.4e-17, (35.9% identity FT in 192 aa overlap). Also similar to Rv1703c, Rv1220c from FT Mycobacterium tuberculosis." FT /db_xref="GOA:O07431" FT /db_xref="InterPro:IPR002935" FT /db_xref="UniProtKB/TrEMBL:O07431" FT /protein_id="CAB09738.1" FT /translation="MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVS FT AQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVARVN FT LQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVAYIQWAIRLARRGAVIV FT VDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR" FT CDS 219486..219917 FT /transl_table=11 FT /locus_tag="Rv0188" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0188, (MTCI28.27), len: 143 aa. Probable conserved FT transmembrane protein, similar to FT T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable FT membrane protein from Streptomyces coelicolor (147 aa), FT FASTA scores: opt: 326, E(): 6.5e-15, (36.2% identity in FT 141 aa overlap); N-terminus of P80185|MTRC_METTH FT TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT C (EC FT 2.1.1.86) from Methanobacterium thermoautotrophicum strain FT Marburg/DSM 2133 (266 aa), FASTA scores: opt: 125, E(): FT 0.033, (31.6% identity in 98 aa overlap). Also similar to FT Rv3635 from Mycobacterium tuberculosis." FT /db_xref="GOA:O07432" FT /db_xref="InterPro:IPR005530" FT /db_xref="UniProtKB/TrEMBL:O07432" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB09739.1" FT /translation="MSTVHSSIDQHPDLLALRASFDRAAESTIAHFTFGLALLAGLYVA FT ASPWIVGFSATRGLPTCDLIVGIAVAYLAYGFASALDRTHGMTWTLPVLGVWVIFSPWV FT LPGVAVTAGMMWSHIIAGAVVAVLGFYFGMRTRAAANQG" FT CDS complement(219996..221723) FT /transl_table=11 FT /gene="ilvD" FT /locus_tag="Rv0189c" FT /product="PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD)" FT /function="INVOLVED IN VALINE AND ISOLEUCINE BIOSYNTHESIS FT (AT THE FOURTH STEP) [CATALYTIC ACTIVITY: FT 2,3-DIHYDROXY-3-METHYLBUTANOATE = 3-METHYL-2- OXOBUTANOATE FT + H(2)O]." FT /EC_number="4.2.1.9" FT /note="Rv0189c, (MTCI28.28c), len: 575 aa. Probable ilvD, FT dihydroxy-acid dehydratase (EC 4.2.1.9), similar to many FT e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) FT from Lactococcus lactis (subsp. lactis) (Streptococcus FT lactis) (570 aa), FASTA scores: opt: 1605, E(): 0, (46.0% FT identity in 561 aa overlap). Also similar to FT ML2608|MLCL622.06c|O06069|ILVD_MYCLE DIHYDROXY-ACID FT DEHYDRATASE from Mycobacterium leprae (564 aa). Contains FT PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases FT signature 1. BELONGS TO THE ILVD / EDD FAMILY. COFACTOR: FT BINDS 1 4FE-4S CLUSTER (POTENTIAL)." FT /db_xref="GOA:P65154" FT /db_xref="InterPro:IPR000581" FT /db_xref="UniProtKB/Swiss-Prot:P65154" FT /protein_id="CAB09740.1" FT /translation="MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARGMLRAVGMDDE FT DFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGYPLEFGTISVSDGISMGHEG FT MHFSLVSREVIADSVEVVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLAAVFLYAGSI FT LPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPGEGACGGMYTANT FT MASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAI FT AVVMAFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMSDVDHI FT GGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVLRALANPIHPSGGIT FT ILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAALDALEDGTITVGDAVVIRYEGPK FT GGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHIAPEAVDGGPIALLRN FT GDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG" FT misc_feature complement(221283..221315) FT /note="PS00886 Dihydroxy-acid and 6-phosphogluconate FT dehydratases signature 1" FT CDS 221871..222161 FT /transl_table=11 FT /locus_tag="Rv0190" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0190, (MTCI28.29), len: 96 aa. Conserved FT hypothetical protein, highly similar to several FT hypothetical proteins e.g. SYCSLRA_35|Q55554|SLL0176 FT hypothetical 18.9 kDa protein from Synechocystis (167 aa), FT FASTA scores: opt: 237, E(): 5.8e-16, (39.4% identity in 94 FT aa overlap). Also highly similar to Z95398|MLCL622_7|O06070 FT from Mycobacterium leprae (135 aa), FASTA score: (82.6% FT identity in 92 aa overlap). Also similar to hypothetical FT proteins from Mycobacterium tuberculosis e.g. Rv0967, FT Rv0030, Rv1766 (42.5% identity in 80 aa overlap)." FT /db_xref="InterPro:IPR003735" FT /db_xref="UniProtKB/TrEMBL:O07434" FT /protein_id="CAB09730.1" FT /translation="MTAAHGYTQQKDNYAKRLRRVEGQVRGIARMIEEDKYCIDVLTQI FT SAVTSALRSVALNLLDEHLSHCVTRAVAEGGPGADGKLAEASAAIARLVRS" FT CDS 222289..223530 FT /transl_table=11 FT /locus_tag="Rv0191" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /function="UNKNOWN; POSSIBLY INVOLVED IN TRANSPORT OF DRUG FT ACROSS THE MEMBRANE." FT /note="Rv0191, (MTCI28.30), len: 413 aa. Probable conserved FT integral membrane protein, member of major facilitator FT superfamily (MFS) possibly involved in transport of drug, FT similar to several hypothetical proteins e.g. FT YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from FT Escherichia coli (396 aa), FASTA scores: opt: 475, E(): FT 4.2e-33, (29.7% identity in 381 aa overlap); and to several FT chloramphenicol resistance proteins e.g. CMLR_STRLI|P31141 FT chloramphenicol resistance protein from stremtomyces FT lividans (392 aa), FASTA scores: opt: 394, E(): 6.7e-12, FT (28.2% identity in 383 aa overlap). Also similar to FT SVU09991_1 from Mycobacterium tuberculosis." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:O07435" FT /protein_id="CAB09731.1" FT /translation="MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGALS FT AIARNLRVSVVLVGTLLSWYALVAAVTTVPLVRWTAHWPRRRALVVSLVCLTVSQLVSA FT LAPNFAVLAAGRVLCAVTHGLLWAVIAPIATRLVPPSHAGRATTSIYIGTSLALVVGSP FT LTAAMSLMWGWRLAAVCVTGAAAAVALAARLALPEMVLRADQLEHVGRRARHHRNPRLV FT KVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLLAAYGVAGLVSVPLVARPLDR FT WPKGAVIVGMTGLTAAFTLLTALAFGERHTAATALLGTGAIVLWGALATAVSPMLQSAA FT MRSGGDDPDGASGLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVALFGMTVS FT QHLFENPTLSPGDG" FT CDS 223564..224664 FT /transl_table=11 FT /locus_tag="Rv0192" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0192, (MTCI28.31), len: 366 aa. Conserved FT hypothetical protein. Has Gly- Arg-rich region followed by FT highly Pro-rich repetitive region near N-terminus. Similar FT in C-terminus to other hypothetical proteins e.g. FT Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 FT aa), FASTA scores: opt: 375, E(): 3.2e-24, (36.1% identity FT in 255 aa overlap); YV09_MYCTU|Q11149|cY20G9.09 FT hypothetical 47.9 kDa protein from Mycobacterium FT tuberculosis (451 aa), FASTA scores: opt: 330, E(): FT 3.2e-13, (35.1% identity in 271 aa overlap). Also similar FT to Rv0116c, Rv1433, Rv2518c, Rv0483 from Mycobacterium FT tuberculosis." FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:O07436" FT /protein_id="CAB09732.1" FT /translation="MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGCW FT RCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLA FT PPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIAD FT RAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSL FT VATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGV FT PVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNF FT GSGDPVVVKNSVGTYNKNDGAQDWQI" FT CDS 223607..223909 FT /transl_table=11 FT /locus_tag="Rv0192A" FT /product="CONSERVED SECRETED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0192A, len: 100 aa. Probable N-terminal part of FT Rv0192, which is member of family P5.17 with Rv0116c, FT Rv1433, Rv2518c, Rv0483. These are all predicted to be FT exported/membrane proteins. Rv0192A has typical N-terminal FT signal peptide which is functional and was identified by FT PhoA fusion screens: O52054 PGB14T-O1 PRECURSOR (FRAGMENT FT 45 AA) (see citation below). Since Rv0192 misses a signal FT peptide this suggests that there is a frameshift in the FT region of the overlap with Rv0192 but none found on FT reinspection of sequence." FT /db_xref="UniProtKB/TrEMBL:Q79FZ8" FT /protein_id="CAE55254.1" FT /translation="MSRWKQGWTRGSLFAALNIAAVVAVLMLGAGVAVADPDAAPGDPG FT GPGAPGAQRDPSTRRQLTCWRRHPTRWRCRRHLTRWRRRHLTRSRRPRLTRWQCR" FT CDS complement(224724..226571) FT /transl_table=11 FT /locus_tag="Rv0193c" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0193c, (MTV033.01c-MTCI28.32), len: 615 aa. FT Hypothetical unknown protein. TBparse score is 0.924." FT /db_xref="UniProtKB/TrEMBL:O07437" FT /protein_id="CAB09761.1" FT /translation="MIQISRDMSSLGQTATTQALPDNSDGIQLTKFAADDILPLEYAPP FT IGPELVSQDQLPAAWAYKRFRDLDDKESYRRKLLQELTDALAAQGSEAAEIATAALRDL FT IDQMAEQGAVVLADIVESDDFLELVKRYDELMAREGSRSFIHRFLDLRRSPGMLTDPAV FT NGALVHPLMIALISYAVGGPIRMIDARGKDAEPLSVLAQDNMLHIDNTPFNDEYKILIT FT WRRGTAQGPAGQNFTFLPGTHKLARTCFVNEDGVPWSSENASIFTTPDSIRKVFDAQRQ FT LGGQDHPTVIEVTDSERPLSGVFAAGSLVHHRFRTASGSARSCIILVFHRVADNPGRMV FT SDVEDSSDVSLSELLTRGVPDESYQQRFIATLCAAADEIAELLLKWKKTPQRPVSLPLQ FT TKQIDGARFEEWISAATKAPEVREIRNRELTIPYGEVLSAEEFFDLIWRLMRFDKHGPL FT DLILYHDNREEPRKWARNLIREMSADRLYERLLGWLADIQQPRPADCLRPLQIHALISE FT VLKTLPLDEDQDPPADWHFDLLGMSHAEAARSVKHLLEDVAEALLRCEDMAAYLSTSLF FT AFWAVDAAYSLDGRRNLVVKDCARRLLRHYTMLSLTCFQ" FT CDS 226878..230462 FT /transl_table=11 FT /locus_tag="Rv0194" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE FT SUBSTRATE ACROSS THE MEMBRANE." FT /note="Rv0194, (MTV033.02), len: 1194 aa. Probable FT drugs-transport transmembrane protein ATP binding protein FT ABC transporter (see citation below), highly similar to FT many e.g. U62129|STU62129_2|T30293 ABC transport protein FT homolog from Salmonella typhi (1218 aa), FASTA scores: opt: FT 1116, E(): 0, (36.3% identity in 1209 aa overlap); FT CAB66302.1|AL136519 ABC transporter protein ATP-binding FT component from Streptomyces coelicolor (1243 aa); I84547 FT mdl protein from Escherichia coli (1143 aa); etc. Also FT similar to MTCY50_9 and MTCY50_10 from Mycobacterium FT tuberculosis, FASTA score: (33.8% identity in 574 aa FT overlap). Contains two PS00017 ATP/GTP-binding site motif A FT (P-loop) and one PS00211 ABC transporters family signature. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS). Alternative start possible at 1823 but no FT RBS." FT /db_xref="GOA:O53645" FT /db_xref="HSSP:1MT0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:O53645" FT /protein_id="CAA17316.1" FT /translation="MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVI FT DDAIAADHRPLAPWAVVLVAAAGATYLLMYVRRYYGGRIAHLVQHDLRMDAFQALLRWD FT GRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAVMTWLSVPLALLAV FT LLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLV FT TASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFVAFWAC FT LTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPEARLSLEFQRVS FT FGYVADRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVR FT ELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIEEFVNTLPD FT GYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECGIQEVLREAI FT ADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERCPRYRELLSPAPDLADDL FT VVAERSPVCRPVAGLGTKAAQHTNVHNPGPHDHPPGPDPLRRLLREFRGPLALSLLLVA FT VQTCAGLLPPLLIRHGIDVGIRRHVLSALWWAALAGTATVVIRWVVQWGSAMVAGYTGE FT QVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLRTGLVVAVISVVTL FT VGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARHRLGTVTATLREYAA FT GLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVALLCSLATTLVLLDGA FT REVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVAAGRIRSLLSTRTPSSP FT AARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTVVFVGSTGSGKSTLIKLV FT ARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGTVRDAIAYGRPDATDAQ FT VERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALARARLVDPDILLLDEAT FT VALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEHGTVVEDGAHTELLA FT AGGHYSRLWAAHTRLCSPEITQLQCIDA" FT misc_feature 227976..227999 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 228288..228332 FT /note="PS00211 ABC transporters family signature" FT misc_feature 229803..229826 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 230899..231534 FT /transl_table=11 FT /locus_tag="Rv0195" FT /product="POSSIBLE TWO COMPONENT TRANSCRIPTIONAL REGULATORY FT PROTEIN (PROBABLY LUXR-FAMILY)" FT /function="POSSIBLY SENSOR PART OF A TWO COMPONENT FT REGULATORY SYSTEM." FT /note="Rv0195, (MTV033.03), len: 211 aa. Possible FT two-component response regulator, luxR family, similar to FT many e.g. U00008|ECOHU49_15 regulatory protein narP from FT Escherichia coli strain K12 (225 aa), FASTA scores: opt: FT 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). FT Start chosen by similarity. Contains probable FT helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 FT SD). TBparse score is 0.931." FT /db_xref="GOA:O53646" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:O53646" FT /protein_id="CAA17317.1" FT /translation="MAPVNVISVAVVASDPLTRDGALARLSSHRELDVRAWQAGCETSV FT LLVLATTITAPLLCQIEDVQKDGPSHAPKLVVVADEFSAEQVFRMIKLGLTGLLYRSQS FT TFDCIVETIRLSAEGRLRLPERVQRYLVGRIKSTPTAEPDTPCAAALAEREVAVLRLLA FT DGLSTHQVAVQLNYCERTIKNIVHDIVTRLKLRNRTHAVAHALRAGLI" FT CDS 231647..232231 FT /transl_table=11 FT /locus_tag="Rv0196" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0196, (MTV033.04), len: 194 aa. Possible FT transcriptional regulatory protein, similar to two Bacillus FT subtilis regulators: P42105|YXAF_BACSU HYPOTHETICAL 21.0 FT kDa PROTEIN (191 aa), FASTA scores: opt: 323, E(): 2.1e-15, FT (30.9% identity in 181 aa overlap); and Z99105|BSUB0002_9 FT negative regulator of the lincomycin operon (188 aa), FASTA FT scores: opt: 255, E(): 1e-10, (25.9 identity in 185 aa FT overlap). TBparse score is 0.885." FT /db_xref="GOA:O53647" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:O53647" FT /protein_id="CAA17318.1" FT /translation="MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYFP FT GGRTQLLCEAVDYAGEHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAVSV FT EAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEGAIL FT LARVRRDLTPLDLVHRQLRNLLLAELPERSR" FT CDS 232231..234519 FT /transl_table=11 FT /locus_tag="Rv0197" FT /product="POSSIBLE OXIDOREDUCTASE" FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR FT METABOLISM." FT /EC_number="1.-.-.-" FT /note="Rv0197, (MTV033.05), len: 762 aa. Possible FT oxidoreductase (EC 1.-.-.-), similar to others e.g. FT 9948789|AAG06102.1|AE004699_7|B83307 probable molybdopterin FT oxidoreductase from Pseudomonas aeruginosa strain PAO1 (769 FT aa); 5441785|CAB46809.1|AL096811|T36812 probable FT dehydrogenase from Streptomyces coelicolor (747 aa), FASTA FT scores: opt: 617, E(): 9.8e-30, (29.9% identity in 762 aa FT overlap); BAB04334.1|AP001509 assimilatory nitrate FT reductase (catalytic subunit) from Bacillus halodurans (743 FT aa); etc. TBparse score is 0.911." FT /db_xref="GOA:O53648" FT /db_xref="InterPro:IPR006657" FT /db_xref="UniProtKB/TrEMBL:O53648" FT /protein_id="CAA17319.1" FT /translation="MTSSDWLPTACILCECNCGIVVQVDDRRLARIRGDKAHPGSAGYT FT CNKALRLDHYQNNRARLSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKIFY FT YGGGGQGNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGGHTRGEFENAEV FT SVFVGKNPWMSQSFPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQPGCDAW FT CLAALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQRCGVDEELLRAAARR FT IGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILTGNFAKKGGQHLHSSFAPLFSQVSG FT RTPVTGAPIIAGLIPGNVVPEEILTEHPDRFRAMIVERGNPAHSLADSAACRAAFQALE FT LMVVVDVAMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFPPLPGTLPE FT PEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVAKLTAYVLYETL FT GPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNALFDAILERPSGVTFTVHNYE FT DDFALISHPDHKIALEIPEMLAEIRSLTQTPSRLTTPQLPIVLSVGERRAYTANDIFRD FT PSWRKRDANGALRVSVEDAQALGLADGCLARITTAAGSAEATVEVTETMLAGHAALPNG FT FGLDYTGDDGRTVVAGVAPNALTSTRWRDPYAGTPWHKHVPAAIRRADAESPIWYPKWA FT ILPARGVLA" FT CDS complement(234516..236507) FT /transl_table=11 FT /locus_tag="Rv0198c" FT /product="PROBABLE ZINC METALLOPROTEASE" FT /function="UNKNOWN; HYDROLYZES PEPTIDES AND/OR PROTEINS." FT /EC_number="3.4.24.-" FT /note="Rv0198c, (MTV033.06c), len: 663 aa. Probable zinc FT metalloprotease (EC 3.4.24.-), equivalent to FT Z95398|MLCL622.12c from Mycobacterium leprae (667 aa), FT FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667 aa FT overlap). Also similar to many other metalloproteases e.g. FT members of the eukaryotic neprilysin family: FT P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA FT scores: opt: 872, E(): 0, (31.1% identity in 692 aa FT overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from FT Lactococcus lactis (626 aa), FASTA scores: opt: 862, E(): FT 0, (30.0% identity in 654 aa overlap). Contains PS00142 FT Neutral zinc metallopeptidases, zinc-binding region FT signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC FT METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY. FT TBparse score is 0.905." FT /db_xref="GOA:O53649" FT /db_xref="HSSP:1DMT" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:O53649" FT /protein_id="CAA17320.1" FT /translation="MTLAIPSGIDLSHIDADARPQDDLFGHVNGRWLAEHEIPADRATD FT GAFRSLFDRAETQVRDLIIQASQAGAAVGTDAQRIGDLYASFLDEEAVERAGVQPLHDE FT LATIDSAADATELAAALGTLQRAGVGGGIGVYVDTDSKDSTRYLVHFTQSGIGLPDESY FT YRDEQHAAVLAAYPGHIARMFGLVYGGESRDHAKTADRIVALETKLADAHWDVVKRRDA FT DLGYNLRTFAQLQTEGAGFDWVSWVTALGSAPDAMTELVVRQPDYLVTFASLWASVNVE FT DWKCWARWRLIRARAPWLTRALVAEDFEFYGRTLTGAQQLRDRWKRGVSLVENLMGDAV FT GKLYVQRHFPPDAKSRIDTLVDNLQEAYRISISELDWMTPQTRQRALAKLNKFTAKVGY FT PIKWRDYSKLAIDRDDLYGNVQRGYAVNHDRELAKLFGPVDRDEWFMTPQTVNAYYNPG FT MNEIVFPAAILQPPFFDPQADEAANYGGIGAVIGHEIGHGFDDQGAKYDGDGNLVDWWT FT DDDRTEFAARTKALIEQYHAYTPRDLVDHPGPPHVQGAFTIGENIGDLGGLSIALLAYQ FT LSLNGNPAPVIDGLTGMQRVFFGWAQIWRTKSRAAEAIRRLAVDPHSPPEFRCNGVVRN FT VDAFYQAFDVTEDDALFLDPQRRVRIWN" FT misc_feature complement(235011..235040) FT /note="PS00142 Neutral zinc metallopeptidases, zinc-binding FT region signature" FT CDS 236550..237209 FT /transl_table=11 FT /locus_tag="Rv0199" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0199, (MTV033.07), len: 219 aa. Probable conserved FT membrane protein, equivalent to Z95398|MLCL622.13 from FT Mycobacterium leprae (224 aa), FASTA scores: opt: 920, E(): FT 0, (67.7% identity in 220 aa overlap). Also some similarity FT to Mce-associated membrane proteins from Mycobacterium FT tuberculosis e.g. Rv0178, Rv0175, etc. TBparse score is FT 0.918." FT /db_xref="UniProtKB/TrEMBL:O53650" FT /protein_id="CAA17321.1" FT /translation="MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGIA FT STLLGVLSVAAVVLGAMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDASLQ FT RLHDGTVGQLNTDFDAVVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAARPVV FT TTKLPPFATRTDSVLLVATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESIR" FT CDS 237206..237895 FT /transl_table=11 FT /locus_tag="Rv0200" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0200, (MTV033.08), len: 229 aa. Possible conserved FT transmembrane protein, equivalent to Z95398|MLCL622.14 from FT Mycobacterium leprae (229 aa), FASTA scores: opt: 1147, FT E(): 0, (74.7% identity in 229 aa overlap). Also some FT similarity to Rv1973 from Mycobacterium tuberculosis (160 FT aa); and Rv1362c|Z75555|MTCY02B10_26 (220 aa), FASTA FT scores: opt: 134, E(): 0.063, (25.8% identity in 159 aa FT overlap). TBparse score is 0.906." FT /db_xref="GOA:O53651" FT /db_xref="UniProtKB/TrEMBL:O53651" FT /protein_id="CAA17322.1" FT /translation="MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVLL FT VVEGVAINFWLLRRDSVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRDFN FT RDSREVVHLATGMAETVASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLARRG FT VTAQAATLAAGVEAIGPSAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGWLVLD FT VTPINAR" FT CDS complement(237892..238395) FT /transl_table=11 FT /locus_tag="Rv0201c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0201c, (MTV033.09c), len: 167 aa. Conserved FT hypothetical protein, equivalent to Z95398|MLCL622.15c from FT Mycobacterium leprae (170 aa), FASTA scores: opt: 646, E(): FT 0, (63.9% identity in 158 aa overlap). TBparse score is FT 0.909." FT /db_xref="UniProtKB/TrEMBL:O53652" FT /protein_id="CAA17323.1" FT /translation="MTLAAEPHPAPPQQPTVAWSEPDVDRRVEFWPTVAIRSALESGDI FT ATWQRIAAALKRDPYGRTARQVEEVLEGIPATGIANAFWEVLDRARTHLDANERAEVAR FT QVGLLLDRSGLQRQEFASRIGVTAQDLTAYLDGIVSPSASLMIRMRRLSDRFVRAKSVR FT AADS" FT CDS complement(238392..241292) FT /transl_table=11 FT /gene="mmpL11" FT /locus_tag="Rv0202c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL11" FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /note="Rv0202c, (MTV033.10c), len: 966 aa. Probable mmpL11, FT conserved transmembrane transport protein (see citation FT below), equivalent to Z95398|MLCL622.16c from Mycobacterium FT leprae (1014 aa), FASTA scores: opt: 4076, E(): 0, (72.8% FT identity in 1017 aa overlap). Member of RND superfamily, FT similar to several putative transport proteins e.g. P96687 FT from Bacillus subtilis (724 aa), FASTA scores: opt: 594, FT E(): 9.1e-29, (26.9% identity in 717 aa overlap); etc. FT BELONGS TO THE MMPL FAMILY. TBparse score is 0.913." FT /db_xref="GOA:P65374" FT /db_xref="InterPro:IPR000731" FT /db_xref="UniProtKB/Swiss-Prot:P65374" FT /protein_id="CAA17324.1" FT /translation="MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVA FT GSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTEAP FT NPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYVIGQ FT GALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITMGLVF FT VLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLA FT VVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKR FT SALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQ FT FDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNV FT VSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQVDVGGPTALI FT KDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQ FT WGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYG FT VRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAM FT FDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAK FT LKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRL FT AVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGY FT LIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQ FT PSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR" FT CDS 241514..241924 FT /transl_table=11 FT /locus_tag="Rv0203" FT /product="POSSIBLE EXPORTED PROTEIN" FT /function="UNKNOWN" FT /note="Rv0203, (MTV033.11), len: 136 aa. Possible exported FT protein (has hydrophobic stretch near N-terminus). Some FT similarity to part of U02459|LDU02459_1 hypothetical FT protein from Leishmania donovani (741 aa), FASTA score: FT opt: 111, E(): 9.1, (30.0% identity in 90 aa overlap). FT TBparse score is 0.901." FT /db_xref="UniProtKB/TrEMBL:O53654" FT /protein_id="CAA17325.1" FT /translation="MKTGTATTRRRLLAVLIALALPGAAVALLAEPSATGASDPCAASE FT VARTVGSVAKSMGDYLDSHPETNQVMTAVLQQQVGPGSVASLKAHFEANPKVASDLHAL FT SQPLTDLSTRCSLPISGLQAIGLMQAVQGARR" FT CDS complement(241976..243214) FT /transl_table=11 FT /locus_tag="Rv0204c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0204c, (MTV033.12c), len: 412 aa. Probable FT conserved transmembrane protein (see citation below), FT equivalent, but has C-terminal extension, to FT Z95398|MLCL622.17c from Mycobacterium leprae (367 aa), FT FASTA scores: opt: 2002, E(): 0, (82.4% identity in 374 aa FT overlap). Some similarity to Rv0585c from Mycobacterium FT tuberculosis. TBparse score is 0.908." FT /db_xref="GOA:O53655" FT /db_xref="InterPro:IPR005242" FT /db_xref="UniProtKB/TrEMBL:O53655" FT /protein_id="CAA17326.1" FT /translation="MSHDAPARNLRQRVGALPRTRVGAPPAEGVPPRGKYWWLRWAVLA FT IVAIVLAIEVALGWDQLAKAWVSLYRAKWWWLLAAVAAAGASMHSFAQIQRTLLKSAGV FT HVKQWRSEAAFYAANSLSTTLPGGPVLSATFLLRQQRIWGASTVVASWQLVMSGVLQAV FT GLALLGLGGAFFLGAKNNPFSLLFTLGGFVTLLLLAQAVASRPELIEGIGRRVLSWANS FT VRGRPADAGLPKWRETLMQLESVSLGRRDLGVAFGWSLFNWIADVACLGFAAYAAGDHA FT SVGGLAVAYAAARAVGTIPLMPGGVLVVEAVLVPGLVSSGMPLPSAISAMLIYRLISWL FT LIAAIGWVVFFFMFRTESTADSDNDRDPPTDPNLRLVIQPQGTPCDDPVETTPQGPAPT FT PDLRPEGGETPPR" FT CDS 243384..244487 FT /transl_table=11 FT /locus_tag="Rv0205" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /function="UNKNOWN" FT /note="Rv0205, (MTV033.13), len: 367 aa. Possible conserved FT transmembrane protein, similar to hypothetical proteins FT from many bacteria e.g. AL0209|SC4H8_6 from Streptomyces FT coelicolor (402 aa), FASTA scores: opt: 436, E(): 1.7e-21, FT (27.2% identity in 349 aa overlap); Z99117|BSUB0014_221 FT from Bacillus subtilis (353 aa), FASTA scores: opt: 394, FT E(): 8.6e-19, (28.7% identity in 324 aa overla). TBparse FT score is 0.885." FT /db_xref="GOA:O53656" FT /db_xref="InterPro:IPR002549" FT /db_xref="UniProtKB/Swiss-Prot:O53656" FT /protein_id="CAA17327.1" FT /translation="MSASLDDASVAPLVRKTAAWAWRFLVILAAMVALLWVLNKFEVIV FT VPVLLALMLSALLVPPVDWLDSRGLPHAVAVTLVLLSGFAVLGGILTFVVSQFIAGLPH FT LVTEVERSIDSARRWLIEGPAHLRGEQIDNAGNAAIEALRNNQAKLTSGALSTAATITE FT LVTAAVLVLFTLIFFLYGGRSIWQYVTKAFPASVRDRVRAAGRAGYASLIGYARATFLV FT ALTDAAGVGAGLAVMGVPLALPLASLVFFGAFIPLIGAVVAGFLAVVVALLAKGIGYAL FT ITVGLLIAVNQLEAHLLQPLVMGRAVSIHPLAVVLAIAAGGVLAGVVGALLAVPTVAFF FT NNAVQVLLGGNPFADVADVSSDHLTEV" FT CDS complement(244484..247318) FT /transl_table=11 FT /gene="mmpL3" FT /locus_tag="Rv0206c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL3" FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID FT TRANSPORT." FT /note="Rv0206c, (MTV033.14c, MTCY08D5.01c), len: 944 aa. FT Possible mmpL3, conserved transmembrane transport protein FT (see Tekaia et al., 1999), equivalent to Z95398|MLCL622.18c FT from Mycobacterium leprae (955 aa), FASTA scores: opt: 806, FT E(): 1.8e-21, (57.2% identity in 243 aa overlap). Member of FT RND superfamily, similar to others. BELONGS TO THE MMPL FT FAMILY. TBparse score is 0.928." FT /db_xref="GOA:O53657" FT /db_xref="InterPro:IPR000731" FT /db_xref="UniProtKB/Swiss-Prot:O53657" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA17328.1" FT /translation="MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFYD FT DGSQSVQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQDHPDQ FT VLGWAGYLRASQATGMATADKKYTFVSIPLKGDDDDTILNNYKAIAPDLQRLDGGTVKL FT AGLQPVAEALTGTIATDQRRMEVLALPLVAVVLFFVFGGVIAAGLPVMVGGLCIAGALG FT IMRFLAIFGPVHYFAQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRRTVITA FT GRTVTFSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLGILGKHV FT DALGVRTLFRVPFLANWKISAAYLNWLADRLQRTKTREEVEAGFWGKLVNRVMKRPVLF FT AAPIVIIMILLIIPVGKLSLGGISEKYLPPTNSVRQAQEEFDKLFPGYRTNPLTLVIQT FT SNHQPVTDAQIADIRSKAMAIGGFIEPDNDPANMWQERAYAVGASKDPSVRVLQNGLIN FT PADASKKLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVILLTTTIVLMFL FT AFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLTAPVIGLIIALVF FT GLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRIITAAALIVAVVAGAFVFSDLV FT MMKYLAFGLMAALLLDATVVRMFLVPSVMKLLGDDCWWAPRWARRLQTRIGLGEIHLPD FT ERKRPVSNGRPARPPVTAGLVAARAAGDPRPPHDPTHPLAESPRPARSSPASSPELTPA FT LEATAAPAAPSGASTTRMQIGSSTEPPTTRLAAAGRSVQSPASTPPPTPTPPSAPSAGQ FT TRAMPLAANRSTDAAGDPAEPTAALPIIRSDGDDSEAATEQLNARGTSDKTRQRRRGGG FT ALSAQDLLRREGRL" FT CDS complement(247384..248112) FT /transl_table=11 FT /locus_tag="Rv0207c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved FT hypothetical protein, equivalent to Z95398|MLCL622_19 from FT Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 FT identity in 199 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:P96389" FT /protein_id="CAB07002.1" FT /translation="MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVWD FT APNLDMGLGSILGRRPTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNIAP FT GSAEVVRPWVDALRNVGFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASADGQ FT AFRQPLEAVARSGTPVQVLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGLDSLP FT EQGAWLQPFRPLSSLLTSRV" FT CDS complement(248115..248906) FT /transl_table=11 FT /locus_tag="Rv0208c" FT /product="HYPOTHETICAL METHLYTRANSFERASE (METHYLASE)" FT /function="CAUSES METHYLATION." FT /EC_number="2.1.1.-" FT /note="Rv0208c, (MTCY08D5.03c), len: 263 aa. Hypothetical FT methyltransferase (EC 2.1.1.-), equivalent to FT Z95398|MLCL622_20 from Mycobacterium leprae (279 aa), FASTA FT score: (64.2% identity in 246 aa overlaps). Also similar to FT others e.g. FT 10178368|CAC08407.1|AL392177|Q9F305|MT04_STRCO|SCD17A.03c FT HYPOTHETICAL METHLYTRANSFERASE from Streptomyces coelicolor FT (271 aa). Could start at aa 7." FT /db_xref="GOA:P67498" FT /db_xref="InterPro:IPR003358" FT /db_xref="UniProtKB/Swiss-Prot:P67498" FT /protein_id="CAB07003.1" FT /translation="MVHHGQMHAQPGVGLRPDTPVASGQLPSTSIRSRRSGISKAQRET FT WERLWPELGLLALPQSPRGTPVDTRAWFGRDAPVVLEIGSGSGTSTLAMAKAEPHVDVI FT AVDVYRRGLAQLLCAIDKVGSDGINIRLILGNAVDVLQHLIAPDSLCGVRVFFPDPWPK FT ARHHKRRLLQPATMALIADRLVPSGVLHAATDHPGYAEHIAAAGDAEPRLVRVDPDTEL FT LPISVVRPATKYERKAQLGGGAVIELLWKKHGCSERDLKIR" FT CDS 249038..250123 FT /transl_table=11 FT /locus_tag="Rv0209" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:P96391" FT /protein_id="CAB07004.1" FT /translation="MRGQGHQIFVDELARFATSSADQRVVAIAQRAAEPLRVAVRGRPG FT VGCRTVARALQGAGSSSGMTVTPQARAADSDVDLVVYVTVEVVKPEDREAIAATRRPVV FT AVLNKADLAGPLSGAGPIVMAQARCAQFSTLLGVPMESMIGLLAVAALDDLDDTLRAVL FT RALAAHPDGFDALDRAVAGFLAAALPVPTEVRLRLLDTLDLFGIALGMAAFRPGRPSRT FT PAQLRTLLRRVSGVDAVIDKVTAAGSEVRYRRLLDAVAELEALAAQAKEIGGPIGEFLR FT DDDTVLARMAAAVDVALAVGLDVGPLDDPAAHLPRAVRWHRYSLDNGDMHRTCGADIAR FT GSLRLWSLAGGMPLHRYRKSS" FT CDS 250120..251598 FT /transl_table=11 FT /locus_tag="Rv0210" FT /product="HYPOTHETICAL PROTEIN" FT /function="UNKNOWN" FT /note="Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical FT unknown protein. Possibly membrane protein; has hydrophobic FT stretches around aa 333 - 381." FT /db_xref="UniProtKB/TrEMBL:P96392" FT /protein_id="CAB07005.1" FT /translation="MIRAASDDPAGVDELVAAIAPGLAGLGLPVINRREVVLVTGPWLA FT GVSGVRAALAERLPQRRFVETAELGPGDAPVAVVFVVSAATALTESDCVLLDTAAEHTD FT AVVAVVSKIDVHRGWRDVLTSNRDRLAARASRYARVPWVGAAAAPELGEPYLDDLVAAI FT QKQLADPAVARRNMLRAWESRLLMVARRFDGDAQSAGRRARVDALRQQRRTVLRQGRQS FT KSEHTIALRAQIQHARVKLSYFARNRCSLLRVELQEHVAGLSRKDIARFAAYTRGRVQE FT VVAEVGEGAVAHLADVAQLLGVPVQPPVLENLPAVLPTVVAPPLTSRRLEIRLTTLLGA FT GFGLGIALTLSRLVAGLTPGLAASGMVAGVAIGLAVTAWVVNARALLHDRVVVDRWTGE FT VTASLRSVVEQLVATRVVAVETLLSTAISERDDAENARVADQVSIIDGELREHAVAAAR FT AAALRDREMPAVRAALEAVRAELGEPGAPTTGLF" FT CDS 251782..253602 FT /transl_table=11 FT /gene="pckA" FT /locus_tag="Rv0211" FT /standard_name="pckG; pck1" FT /product="PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE FT CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) FT (PEPCK)(PEP CARBOXYKINASE)" FT /function="RATE-LIMITING GLUCONEOGENIC ENZYME [CATALYTIC FT ACTIVITY: GTP + OXALOACETATE = GDP + PHOSPHOENOLPYRUVATE + FT CO2]." FT /EC_number="4.1.1.32" FT /note="Rv0211, (MTCY08D5.06), len: 606 aa. Probable pckA FT (alternate gene names: pckG and pck1), iron-regulated FT phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32), FT equivalent to Z95398|MLCL622_21 PROBABLE FT PHOSPHOENOLPYRUVATE CARBOXYKINASE from Mycobacterium leprae FT (609 aa), FASTA score: (86.1% identity in 605 aa overlap). FT Also highly similar to others e.g. PPCK_NEOFR|P22130 FT phosphoenolpyruvate carboxykinase [GTP] (608 aa), FASTA FT scores: opt: 2287, E(): 0, (55.9% identity in 598 aa FT overlap). Contains PS00505 Phosphoenolpyruvate FT carboxykinase (GTP) signature. BELONGS TO THE FT PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] FAMILY." FT /db_xref="GOA:P65686" FT /db_xref="HSSP:1KHB" FT /db_xref="InterPro:IPR008210" FT /db_xref="UniProtKB/Swiss-Prot:P65686" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB07006.1" FT /translation="MTSATIPGLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEEF FT QRLCDQLVEAGTFIRLNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNWMD FT PGEMRSIMKDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMTRMG FT KAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGSGYGG FT NALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAML FT QPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGN FT TVFTNVALTDDGDVWWEGLEGDPQHLIDWKGNDWYFRETETNAAHPNSRYCTPMSQCPI FT LAPEWDDPQGVPISGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSEQTAAAEGKVGN FT VRRDPMAMLPFLGYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDGRFLWPGFGE FT NSRVLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALAVDADEWRQEL FT PLIEEWLQFVGEKLPTGVKDEFDALKERLG" FT misc_feature 252586..252612 FT /note="PS00505 Phosphoenolpyruvate carboxykinase (GTP) FT signature" FT CDS complement(253669..254640) FT /transl_table=11 FT /gene="nadR" FT /locus_tag="Rv0212c" FT /standard_name="nadI" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN NADR FT (PROBABLY ASNC-FAMILY)" FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." FT /note="Rv0212c, (MTCY08D5.07c), len: 323 aa. Possible nadR FT (alternate gene name: nadI), transcriptional regulator, FT similar to others e.g. NADR_ECOLI|P27278 transcriptional FT regulator from Escherichia coli (410 aa), FASTA scores: FT opt: 377, E (): 1e-17, (31.1% identity in 347 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:P96394" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/TrEMBL:P96394" FT /protein_id="CAB07007.1" FT /translation="MTHGMVLGKFMPPHAGHVYLCEFARRWVDELTIVVGSTAAEPIPG FT AQRVAWMRELFPFDRVVHLANENPQRPWEHPDFWDIWKASLQGVLATRPDFVFGAEPYN FT ADFAQVLGARFVAVDHGRTVVPVTATDIRADPLGHWQHIPRCVRPAFVKRVSIIGPEST FT GKTTLAQAVAEKLRTKWVPERAKMLRELNGGSLIGLEWAEIVRGQIASEEALARDADRV FT LICDTDPLATTVWAEFLAGGCPQELRDLARRPYDLTLLTTPDVPWDADDGRCVPGARGT FT FFARCEQALRAAGRSFVVITGGWEERLSVSLRAVEELVRARR" FT misc_feature complement(254143..254166) FT /note="PS00017 ATP/GTP-binding site motif A" FT CDS complement(254637..255950) FT /transl_table=11 FT /locus_tag="Rv0213c" FT /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" FT /function="CAUSES METHYLATION." FT /EC_number="2.1.1.-" FT /note="Rv0213c, (MTCY08D5.08c), len: 437 aa. Possible FT methyltransferase (EC 2.1.1.-), weakly similar to others FT methyltransferases e.g. AF127374_30|LINA from Streptomyces FT lavendulae (611 aa), FASTA scores: opt: 400, E(): 8.1e-19, FT (27.3% identity in 388 aa overlap); Q50258 fortimicin kl1 FT methyltransferase (553 aa), FASTA scores: opt: 267, E(): FT 1.2e-13, (29.3% identity in 351 aa overlap)." FT /db_xref="GOA:P96395" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:P96395" FT /protein_id="CAB07008.1" FT /translation="MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPR FT LVGFSCIDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGE FT VAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADG FT FAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSIT FT DDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFI FT GVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVR FT LLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVV FT AKVAPDVGISFDEAEAYFLSRLDEWENVIAGRIAEATS" FT CDS 256064..257677 FT /transl_table=11 FT /gene="fadD4" FT /locus_tag="Rv0214" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD4 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." FT /EC_number="6.2.1.-" FT /note="Rv0214, (MTCY08D5.09), len: 537 aa. Probable fadD4, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT e.g. 4CL_PINTA|P41636 4-coumarate--CoA ligase (EC 6.2.1.12) FT (537 aa), FASTA scores: opt: 622, E(): 1e-31, (30.0% FT identity in 514 aa overlap). Also similar to others from FT Mycobacterium tuberculosis e.g. MTCY6A4.14 FASTA score: FT (30.7% identity in 501 aa overlap); MTCY493_27, FT MTCY07A7_11, MTCI28_6. Contains PS00455 putative FT AMP-binding domain signature." FT /db_xref="GOA:P96396" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:P96396" FT /protein_id="CAB07009.1" FT /translation="MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKPA FT VILYPSGTVISFDELEARANRLAHWFRQAGLREDDVVAILMENNEHVHAVMWAARRSGL FT YYVPINTHLTASEAAYIVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGGGLV FT GWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALL FT DFWMDADSVYLSPAPMYHTAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHAQ FT FVPAMFVRMLKLPEAVRNSYDMSSLRRVIHAAAPCPVQIKEQMIHWWGPIIDEYYASSE FT ASGSTLITAEDWLTHPGSVGKPIQGGVHIVGADGSELPPNQPGEIYFEGGYPFEYLNDP FT AKTAASRNKHGWVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKV FT LDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQ FT LPRTDTGKLYKSGLVEKYSV" FT misc_feature 256628..256663 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(257783..258856) FT /transl_table=11 FT /gene="fadE3" FT /locus_tag="Rv0215c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE3" FT /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADA |