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EBI DbfetchID BX248346; SV 1; linear; genomic DNA; STD; PRO; 316050 BP. XX AC BX248346; XX DT 10-JUN-2003 (Rel. 76, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 13/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-316050 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF01066; 6C. XX FH Key Location/Qualifiers FH FT source 1..316050 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS complement(526..918) FT /transl_table=11 FT /gene="Mb3416c" FT /locus_tag="Mb3416c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3416c, -, len: 130 aa. Equivalent to Rv3384c, len: FT 130 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 130 aa overlap). Hypothetical protein, FT similar to Mycobacterium tuberculosis hypothetical proteins FT P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: FT 266, E(): 1.6e-10, (43.1% identity in 130 aa overlap); and FT Q50717|YY08_MYCTU|Rv3408|MTCY78.20c (136 aa), FASTA scores: FT opt: 243, E(): 4.8e-09, (35.1% identity in 131 aa FT overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:Q7TWL0" FT /protein_id="CAD95604.1" FT /translation="MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVM FT RALLDKGESARKAGRRALAHLDLLRVDKRVLDLAGGLLPFELRTLDAIHLATAQRLGVD FT LGRLCTYDDRMRDAAKTLGMAVIAPS" FT CDS complement(918..1226) FT /transl_table=11 FT /gene="Mb3417c" FT /locus_tag="Mb3417c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3417c, -, len: 102 aa. Equivalent to Rv3385c, len: FT 102 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 102 aa overlap). Hypothetical protein, FT similar to other Mycobacterium tuberculosis hypothetical FT proteins e.g. Q50718|Y09M_MYCTU|MTCY78.21c|Rv3407|MT3515 FT (99 aa), FASTA scores: opt: 155, E(): 0.001, (41.05% FT identity in 78 aa overlap); O07782|Rv0596c|MTCY19H5.26 (85 FT aa), FASTA scores: opt: 136, E(): 0.016, (39.45% identity FT in 71 aa overlap); P96916|Rv0626|MTCY20H10.07 (86 aa), FT FASTA scores: opt: 130, E(): 0.04, (51.2% identity in 41 aa FT overlap); etc. Also similar to PREVENT HOST DEATH (PHD) FT PROTEINS e.g. CAA66834|PHD from Escherichia coli (73 aa), FT FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa FT overlap); and Q06253|PHD_BPP1 from Bacteriophage P1 (73 FT aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in FT 66 aa overlap)." FT /db_xref="InterPro:IPR006442" FT /db_xref="UniProtKB/TrEMBL:Q7TWK9" FT /protein_id="CAD95605.1" FT /translation="MTPTACATVSTMTSVGVRALRQRASELLRRVEAGETIEITDRGRP FT VALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPSVTLARLREHER" FT repeat_region 1268..1269 FT /rpt_type=DIRECT FT /note="2 bp direct repeat, GT, flanking IS element IS1560." FT repeat_region 1270..1294 FT /rpt_type=INVERTED FT /note="25 bp inverted repeat, IRL, FT TAATTACTAGGACCTGAAAAAGTCG, flanking IS element IS1560." FT repeat_region 1270..2837 FT /mobile_element="insertion sequence:IS1560" FT /locus_tag="IS1560-2" FT /note="IS1560-2, len: 1568 nt. Equivalent to IS1560, len: FT 1568 nt, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 1568 nt overlap). Possible IS element FT 1560. Second copy in MTCY10G2 fr om: 11273 to: 12919." FT CDS 1375..2079 FT /transl_table=11 FT /gene="Mb3418" FT /locus_tag="Mb3418" FT /product="POSSIBLE TRANSPOSASE" FT /note="Mb3418, -, len: 234 aa. Equivalent to Rv3386, len: FT 234 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 234 aa overlap). Possible transposase, FT showing very weak similarity to several IS element FT transposases. Highly similar (but shorter) to FT P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis FT (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% FT identity in 87 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWK8" FT /protein_id="CAD95606.1" FT /translation="MFRTVGDQASLWESVLPEELRRLPEELARVDALLDDSAFFCPFVP FT FFDPRMGRPSIPMETYLRLMFLKFRYRLGYESLCREVTDSITWRRFCRIPLEGSVPHPT FT TLMKLTTRCGEDAVAGLNEALLAKAASEKLLRTNKVRADTTVVEGDVGYPTDTGLLAKA FT VGSMARTVARIKAADAGSAPLGGSSGPRDRLQAAVTRRAATRSGAGLRAPDHRGASRDR FT RAGADRGCRGGT" FT CDS 2069..2746 FT /transl_table=11 FT /gene="Mb3419" FT /locus_tag="Mb3419" FT /product="POSSIBLE TRANSPOSASE" FT /note="Mb3419, -, len: 225 aa. Equivalent to Rv3387, len: FT 225 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 225 aa overlap). Possible transposase, FT showing very weak similarity to other IS element proteins, FT and similar to various hypothetical proteins." FT /db_xref="GOA:Q7TWK7" FT /db_xref="InterPro:IPR002559" FT /db_xref="UniProtKB/TrEMBL:Q7TWK7" FT /protein_id="CAD95607.1" FT /translation="MVRNAQRAVRRASGRRKAWLRQAINHLEKLIGRTERVVDQARSRL FT AGVMPDSSSRLVSLHDADARPIRKGRLGKPVEFGYKAQVVDNADGVILDHSVELGNPAD FT APQLAPAIERISRRTGRPPRAVTADRGCGDASVEDDLHQLGVRNVAIPRKSKPSATRRA FT FEHRRAFRDKIKWRTGSEGRINHLKRSYGWNRTELTGITGARTWCGHGVFAHNLVKIST FT LAA" FT repeat_region complement(2813..2837) FT /rpt_type=INVERTED FT /note="25 bp inverted repeat, IRR, FT TAATTACTAAGACCTGAAAAAGTCG, flanking IS element IS1560." FT repeat_region 2838..2839 FT /rpt_type=DIRECT FT /note="2 bp direct repeat, GT, flanking IS element IS1560." FT CDS 2936..5185 FT /transl_table=11 FT /gene="PE_PGRS52" FT /locus_tag="Mb3420" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb3420, PE_PGRS52, len: 749 aa. Similar to Rv3388, FT len: 731 aa, from Mycobacterium tuberculosis strain H37Rv, FT (94.8% identity in 734 aa overlap). Member of the M. FT tuberculosis PE family, PGRS subfamily of gly-rich FT proteins, similar to many PE-family proteins from M. FT tuberculosis strains H37Rv and CDC1551 e.g. FT O53553|YZ08_MYCTU|RV3508|MTV023.15 (1901 aa), FASTA scores: FT opt: 2380, E(): 3.6e-87, (53.8% identity in 773 aa FT overlap); and MTV023_21, MTV023_18, MTV023_14, MTV039_16, FT MTCY441_4. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, insertions of 60 bp and 78 bp, and deletions of 75 FT bp and 9 bp (cggcggcgc-*), lead to a longer product FT compared to the homolog in Mycobacterium tuberculosis FT strain H37Rv (749 aa versus 731 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TWK6" FT /protein_id="CAD95608.1" FT /translation="MSFVIANPEMLAAAATDLAGIRSAISAATAAAAAPTIQVAAAGAD FT EVSLAISALFGQHAQAYQALSAQATIFHDQFVQALTSGGNLYAAAESHTVEQMVLNAIN FT APTQTLFGRPLIGDGANGTAENPDGQNGGLLFGNGGNGFTQTTAGVAGGNGGSAGLIGN FT GGAGGIGGAGTGTGGHGGAGGAGGRAWLWGTGGAGGAGAAAIGNAVTPGGAGGAGGAGG FT DGGWLFGDGGAGGTGGNGGSGFNSLTSSVGGAGGAGGHAGLFGAGGTGGTGGIGGQNTE FT TGPAASNGGAGGAGGGGGYLVGDGGAGGTGGAGGKNSSGGATLTGGTGGTGGAGGAAGW FT LYGSGGAGGAGGLNNAGGATGGTGGTGGAGGSGAWLYGNGGAAGAGGNGGNNTSAGTGG FT VGASGGTGGNAGLIGAGGHGGAGGAGGNQTGGVGNGGAGGNGGAGGAGGQLYGNGGDGG FT NGGAGGANIAGGNGSDGGAAGHGGAGGSARLIGAGGHGGDGGAGGNTAGRRADAIAGTG FT GDGGNGGNGGLLSGNAGAGGHGGAGGSSTATTTTGTPPTGATGGNGGNGGAGGTAGFTG FT SGGIGGNGGAGGTGGNAGVALSVGSTGGLGGNGGSGGLGGGGGSLFGNGGAGGVGATGG FT NAGSGIGPASVGGNGGKGGVGAAGGLAGQIGNGGSGGSGGAGGNGGTGDTAGNGGNGGA FT GAVGGNAQLIGNGGNGGGGGNGGTGATPGTGGAGAAGGTGGTLFGAPGTTGADGT" FT CDS complement(5256..6128) FT /transl_table=11 FT /gene="Mb3421c" FT /locus_tag="Mb3421c" FT /product="POSSIBLE DEHYDROGENASE" FT /EC_number="1.-.-.-" FT /note="Mb3421c, -, len: 290 aa. Equivalent to Rv3389c, len: FT 290 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 290 aa overlap). Possible dehydrogenase FT (EC 1.-.-.-), similar to parts of several bacterial FT dehydrogenases and eukaryotic short-chain dehydrogenases FT involved in steroid biosynthesis e.g. Q9UVH9|FOX2 FOX2 FT PROTEIN (a multifunctional protein of the peroxisomal FT beta-oxidation) (SIMILAR TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Glomus mosseae FT (1015 aa), FASTA scores: opt: 649, E(): 7.5e-33, (40.9% FT identity in 269 aa overlap); Q9L009|SCC30.12c PUTATIVE FT DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA FT scores: opt: 602, E(): 2.7e-30, (40.35% identity in 305 aa FT overlap); AAH03098 HYDROXYSTEROID (17-BETA) DEHYDROGENASE 4 FT from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, FT E(): 2.1e-29, (41.55% identity in 272 aa overlap); FT P51659|DHB4_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE 4 from FT Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): FT 2.1e-29, (41.55% identity in 272 aa overlap); FT Q19058|E04F6.3 HYDRATASE-DEHYDROGENASE-EPIMERASE from FT Caenorhabditis elegans (298 aa), FASTA scores: opt: 573, FT E(): 1.6e-28, (41.0% identity in 266 aa overlap); O42484 FT 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE IV from Gallus FT gallus (Chicken) (735 aa), FASTA scores: opt: 573, E(): FT 3.2e-28, (39.8% identity in 279 aa overlap); etc. And also FT similar in part to Q9LBK1|PHAJ2|PA1018 (R)-SPECIFIC FT ENOYL-COA HYDRATASE from Pseudomonas aeruginosa (288 aa), FT FASTA scores: opt: 601, E(): 2.7e-30, (40.5% identity in FT 294 aa overlap). And similar to FT P71863|UFAA2|Rv3538|MTCY03C7.18c HYPOTHETICAL 30.2 KDA FT PROTEIN from Mycobacterium tuberculosis (286 aa), FASTA FT scores: opt: 609, E(): 8.7e-31, (39.65% identity in 285 aa FT overlap). HAS SOME SIMILARITY TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7TWK5" FT /db_xref="InterPro:IPR002539" FT /db_xref="UniProtKB/TrEMBL:Q7TWK5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95609.1" FT /translation="MAIDPNSIGAVTEPMLFEWTDRDTLLYAIGVGAGTGDLAFTTENS FT HGIDQQVLPTYAVICCPAFGAAAKVGTFNPAALLHGSQGIRLHAPLPAAGKLSVVTEVA FT DIQDKGEGKNAIVVLRGRGCDPESGSLVAETLTTLVLRGQGGFGGARGERPAAPEFPDR FT HPDARIDMLTREDQALIYRLSGDRNPLHSDPWFATQLAGFPKPILHGLCTYGVAGRALV FT AELGGGVAANITSIAARFTKPVFPGETLSTVIWRTEPGRAVFRTEVAGSDGAEARVVLD FT DGAVEYVAG" FT CDS 6202..6912 FT /transl_table=11 FT /gene="lpqD" FT /locus_tag="Mb3422" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPQD" FT /note="Mb3422, lpqD, len: 236 aa. Equivalent to Rv3390, FT len: 236 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 236 aa overlap). Probable lpqD, a FT conserved lipoprotein with some similarity to various FT bacterial proteins e.g. Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE FT from Streptomyces coelicolor (224 aa), FASTA scores: opt: FT 416, E(): 2.5e-18, (33.0% identity in 197 aa overlap); FT Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from FT Amycolatopsis methanolica (205 aa), FASTA scores: opt: 314, FT E(): 3.7e-12, (28.55% identity in 203 aa overlap); FT P73454|SLR1748 HYPOTHETICAL 24.2 KDA PROTEIN from FT Synechocystis sp. strain PCC 6803 (214 aa), FASTA scores: FT opt: 201, E(): 2.8e-05, (23.8% identity in 189 aa overlap); FT etc. Also similar to Mycobacterium tuberculosis FT hypothetical proteins e.g. O53817|Rv0754|MTV041.28 FT PGRS-FAMILY PROTEIN (584 aa), FASTA scores: opt: 219, E(): FT 5.1e-06, (39.8% identity in 226 aa overlap). Contains FT signal sequence and appropriately positioned PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/TrEMBL:Q7TWK4" FT /protein_id="CAD95610.1" FT /translation="MAKRTPVRKACTVLAVLAATLLLGACGGPTQPRSITLTFIRNAQS FT QANADGIIDTDMPGSGLSADGKAEAQQVAHQVSRRDVDSIYSSPMAADQQTAGPLAGEL FT GKQVEILPGLQAINAGWFNGKPESMANSTYMLAPADWLAGDVHNTIPGSISGTEFNSQF FT SAAVRKIYDSGHNTPVVFSQGVAIMIWTLMNARNSRDSLLTTHPLPNIGRVVITGNPVT FT GWRLVEWDGIRNFT" FT CDS 6958..8910 FT /transl_table=11 FT /gene="acrA1" FT /locus_tag="Mb3423" FT /product="POSSIBLE MULTI-FUNCTIONAL ENZYME WITH FT ACYL-CoA-REDUCTASE ACTIVITY ACRA1" FT /EC_number="1.2.1.-" FT /note="Mb3423, acrA1, len: 650 aa. Equivalent to Rv3391, FT len: 650 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 650 aa overlap). Possible acrA1, multi FT functional protein with fatty acyl-CoA reductase activity FT in C-terminal part (EC 1.2.1.-). Indeed C-terminal part FT highly similar to P94129|ACR1 FATTY ACYL-COA REDUCTASE from FT Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: FT 767, E(): 1.4e-36, (45.4% identity in 260 aa overlap); and FT similar to other oxidoreductases dehydrogenases/reductases FT e.g. Q9Y3A1 CGI-93 PROTEIN (SIMILARITY WITH SDR FAMILY) FT from Homo sapiens (Human) (291 aa), FASTA scores: opt: 363, FT E(): 1.5e-13, (38.65% identity in 194 aa overlap); FT Q9L146|SC6D11.09 PUTATIVE OXIDOREDUCTASE (SIMILARITY WITH FT SDR FAMILY) from Streptomyces coelicolor (343 aa), FASTA FT scores: opt: 346, E(): 1.6e-12, (30.4% identity in 283 aa FT overlap); Q9HSR4|YUSZ1|VNG0115G OXIDOREDUCTASE from FT Halobacterium sp. strain NRC-1 (260 aa), FASTA scores: opt: FT 338, E(): 3.7e-12, (33.85% identity in 248 aa overlap); FT etc. C-terminus also similar to Mycobacterium tuberculosis FT proteins Q10783|YF43_MYCTU|Rv1543|MTCY48.22c PUTATIVE FT OXIDOREDUCTASE (341 aa), FASTA scores: opt: 787, E(): FT 1.2e-37, (39.8% identity in 319 aa overlap); FT O06413|Rv0547c|MTCY25D10.26c HYPOTHETICAL 31.8 KDA PROTEIN FT (294 aa), FASTA scores: opt: 565, E(): 4.7e-25, (36.8% FT identity in 242 aa overlap); O53398|Rv1050|MTV017.03 FT OXIDOREDUCTASE (SDR FAMILY) (301 aa), FASTA scores: opt: FT 436, E(): 1.1e-17, (32.2% identity in 292 aa overlap). FT N-terminus (aa 1-320) is similar to P37693|HETM_ANASP FT polyketide synthase hetM from Anabaena sp. (506 aa), FASTA FT scores: opt: 188, E(): 1.3e-07, (27.7% identity in 361 aa FT overlap); so certainly a multi-domain enzyme. SEEMS TO FT BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FT FAMILY. Note that this ORF corresponds to the gene FT ORF2|Q11197 (in citation mentioned below), but longer 266 FT aa, due to use of a more upstream start site." FT /db_xref="GOA:Q7TWK3" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TWK3" FT /protein_id="CAD95611.1" FT /translation="MRYVVTGGTGFIGRHVVSRLLDGRPEARLWALVRRQSLSRFERLA FT GQWGDRVRPLVGDLTELELSERTIAELGDIDHVLHCAAVHDTTWADATRAVIELAARLD FT ATFHHVSSIAVAGDFAGHYTEADFDVGQRLPTPYHRMTFEAERLVRSTPGLRYRIYRPA FT VVVGDSRTGEMDTIDGPYYLFGVLAKLAVLPSFTPMLLPDIGRTNIVPVDYVADALVAL FT MHADGRDGQTFHLTAPTAIGLRGIYRGIAGAAGLPPLLGTLPGFVAAPVLNARGRAKVL FT RNMAATQLGIPAEIFDVVGCAPTFTSDTTREALRGTGIHVPEFATYAPGLWRYWAEHLD FT PDRARRNDPLLGRHVIITGASSGIGRASAIAVAKRGATVFALARNGNALDELVTEIRAH FT GGQAHAFTCDVTDSASVEHTVKDILGRFDHVDYLVNNAGRSIRRSVVNSTDRLHDYERV FT MAVNYFGAVRMVLALLPHWRERRFGHVVNVSSAGVQARNPKYSSYLPTKAALDAFADVV FT ASETLSDHITFTNIHMPLVATPMIVPSRRLNPVRAISAERAAAMVIRGLVEKPARIDTP FT LGTLAEAGNYVAPRLSRRILHQLYLGYPDSAAAQGISRPDADRPPAPRRPRRSARAGVP FT RPLRRLGRLVPGVHW" FT CDS complement(8911..9774) FT /transl_table=11 FT /gene="cmaA1" FT /locus_tag="Mb3424c" FT /product="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 FT CMAA1 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) FT (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1)" FT /EC_number="2.1.1.79" FT /note="Mb3424c, cmaA1, len: 287 aa. Equivalent to Rv3392c, FT len: 287 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 287 aa overlap). cmaA1, cyclopropane FT mycolic acid synthase 1 (EC 2.1.1.79), characterized in FT 1995 as CFA1_MYCTU|Q11195|CMAA1|CMA1 FT cyclopropane-fatty-acyl-phospholipid synthase 1 (see FT citations below). Highly similar to Mycobacterium FT tuberculosis proteins MTCY20H10.23c (58.7% identity in 286 FT aa overlap); MTCY20H10.24c (68.6% identity); MTCY20H10.25c FT (73.5% identity); MTCY20H10.26c (57.0% identity); and FT MTCY20G9.30c (55.7% identity). Also highly similar to FT Q9CBK3|MMAA4|ML1903 METHYL MYCOLIC ACID SYNTHASES from FT Mycobacterium leprae (298 aa), FASTA scores: opt: 1098, FT E(): 1e-63, (57.0% identity in 286 aa overlap). Equivalent FT to AAK44898|MT0672 from Mycobacterium tuberculosis strain FT CDC1551 (317 aa) but shorter 30 aa and with some FT differences in residues between the proteins." FT /db_xref="GOA:Q7TWK2" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/TrEMBL:Q7TWK2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95612.1" FT /translation="MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTL FT QEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQ FT QLVANSESLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGV FT MLLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPGGRLPSIPMVQECASANGFTV FT TRVQSLQPHYAKTLDLWSAALQANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVN FT QFTCQK" FT CDS 9798..10724 FT /transl_table=11 FT /gene="iunH" FT /locus_tag="Mb3425" FT /product="PROBABLE NUCLEOSIDE HYDROLASE IUNH (PURINE FT NUCLEOSIDASE)" FT /EC_number="3.2.2.-" FT /note="Mb3425, iunH, len: 308 aa. Equivalent to Rv3393, FT len: 308 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 308 aa overlap). Probable iunH, FT nucleoside hydrolase (EC 3.2.2.-), similar to others e.g. FT Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa), FASTA FT scores: opt: 497, E(): 6e-24, (34.3% identity in 312 aa FT overlap); Q27546|IUNH_CRIFA from Crithidia fasciculata (314 FT aa), FASTA scores: opt: 475, E(): 1.4e-22, (31.45% identity FT in 318 aa overlap); Q9CK67|IUNH from Pasteurella multocida FT (310 aa), FASTA scores: opt: 464, E(): 6.9e-22, (30.9% FT identity in 314 aa overlap); Q9A549|CC2615 from Caulobacter FT crescentus (323 aa), FASTA scores: opt: 464, E(): 7.2e-22, FT (37.85% identity in 280 aa overlap); etc. Note that also FT similar to BAB34113|ECS0690 (alias AAG54985|YBEK) PUTATIVE FT TRNA SYNTHETASE from Escherichia coli strain O157:H7 (311 FT aa), FASTA scores: opt: 483, E(): 4.5e-23, (33.0% identity FT in 315 aa overlap). The active site histidine is FT conserved." FT /db_xref="GOA:Q7TWK1" FT /db_xref="HSSP:1EZR" FT /db_xref="InterPro:IPR001910" FT /db_xref="UniProtKB/TrEMBL:Q7TWK1" FT /protein_id="CAD95613.1" FT /translation="MSVVFADVDTGIDDALAVIYLLASPDADLVGIASTGGNIAVGQVC FT ANNLSLLELCGAADIPVSKGADEPLGGRWPDHPKFHGPKGIGYAELPASNRRLTDYDAT FT TAWIAAAHSHAGDLIGLVTGPLTNLALALRAEPALPRLLRRLVIMGGMFDGQPITEWNI FT RVDPEAASEVFTAWAGQRQLPIVCGLDLTRRVAMTPDILARLASVCGSSPVMRVIEDAL FT RFYFESHEARGHGYLAYMHDPLAAAVAMDPELLTTRTATVDVDPTGATVTDWSGKRNPN FT ARIGMSVDPAVFFDRFVERIGRFARRT" FT CDS complement(10779..12362) FT /transl_table=11 FT /gene="Mb3426c" FT /locus_tag="Mb3426c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3426c, -, len: 527 aa. Equivalent to Rv3394c, len: FT 527 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.810% identity in 527 aa overlap). Hypothetical protein, FT with some similarity to various bacterial proteins e.g. FT BAB51085|MLR4427 HYPOTHETICAL PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (545 aa), FASTA scores: opt: 267, E(): FT 2.8e-08, (26.5% identity in 509 aa overlap); FT BAB48362|MLR0866 DNA DAMAGE INDUCIBLE PROTEIN P from FT Rhizobium loti (Mesorhizobium loti) (438 aa), FASTA scores: FT opt: 245, E(): 4.6e-07, (25.5% identity in 290 aa overlap); FT Q9S292|SCI11.27c HYPOTHETICAL PROTEIN from Streptomyces FT coelicolor (322 aa), FASTA scores: opt: 202, E(): 0.00012, FT (28.5% identity in 323 aa overlap); etc. Also similarity FT with P95102|DINP|RV3056|MTCY22D7.25c HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (346 aa), FASTA scores: FT opt: 211, E(): 3.9e-05, (26.45% identity in 306 aa FT overlap). Equivalent to AAK47838 from Mycobacterium FT tuberculosis strain CDC1551 (492 aa) but longer 35 aa." FT /db_xref="GOA:Q7TWK0" FT /db_xref="InterPro:IPR017963" FT /db_xref="UniProtKB/TrEMBL:Q7TWK0" FT /protein_id="CAD95614.1" FT /translation="MMASARVLAIWCMDWPAVAAAAAAGLSATAPVAVTLANRVIACSA FT TARAAGVRRGLRRREAAARCPQLFIATADADRDARLFEGVIAAVDDLVPRAELLRPGLL FT VLPVRGPARFFGSEQMAAERLIDAVAAAGAECQVGIADRLSTAVFAARAGRIVEPGGDA FT RFLSLLSIRQLATEPSLSGPGRDDLTDLLWRMGIRTIGQFAALSRTDVASRFGADAVAA FT HRFARGEPERAPCGREPPPDLAAELACDPPIDRVDAAAFAGRSLAAELHRALMAAGVGC FT TRLAIHAVTANGEERSRVWRCAEPLTEDATADRVRWQLDGWLNNRNARDRPTAAVTLLR FT LQAVETVSASEGLQLPLWGGLGEQDRLRARRALVRVQGLLGPEAVRVPVLSGGHGPAER FT ITLTVLGLVAPEPVPQADPGQPWPGRLPDPSPAVLFDDPVDLLDAQGNPIRVTSRGMFS FT ADPARLRVRGRDDRLRWWAGPWPDDERWWDPDRASGRTARAQVLLDGDPGTALLLCYRQ FT RRWYLEGSYE" FT CDS complement(12359..12973) FT /transl_table=11 FT /gene="Mb3427c" FT /locus_tag="Mb3427c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3427c, -, len: 204 aa. Equivalent to Rv3395c, len: FT 204 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.0% identity in 204 aa overlap). Conserved hypothetical FT protein, with some similarity with RECA PROTEINS FT (RECOMBINASES A) e.g. P16238|RECA_THIFE from Thiobacillus FT ferrooxidans (346 aa), FASTA scores: opt: 131, E(): 1.1, FT (31.45% identity in 140 aa overlap); Q59560|RECA_MYCSM from FT M. smegmatis (349 aa), FASTA scores: opt: 121, E(): 4.4, FT (30.25% identity in 129 aa overlap); etc. Note that FT shortened since first submission to avoid overlap with FT Rv3395A. Equivalent to AAK47839 from Mycobacterium FT tuberculosis strain CDC1551 (227 aa) but shorter 23 aa." FT /db_xref="UniProtKB/TrEMBL:Q7TWJ9" FT /protein_id="CAD95615.1" FT /translation="MTVAFASDQRLENGAEQLESLRRQMALLSEKVSGGPSRSGDLVPA FT GPVSLPPGTVGVLSGARSLLLSMVASVTAAGGNAAIVGQPDIGLLAAVEMGADLSRLAM FT IPDPGTDPVEVAAVLIDGMDLVVLGLGGRRVTRARARAVVARARQKGCTLLVTDGDWQG FT VSTRLAARVCGYEITPALRGVPTPGLGRISGVRLQINGRGR" FT CDS 13056..13682 FT /transl_table=11 FT /gene="Mb3428" FT /locus_tag="Mb3428" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb3428, -, len: 208 aa. Equivalent to Rv3395A, len: FT 208 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 208 aa overlap). Probable membrane FT protein, with potential transmembrane stretches from aa FT 7..25 and 55..77. Weak similarity to Q9F2P3|SCE41.16C FT PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (258 aa), FT FASTA scores: opt: 107, E(): 7.4, (34.05% identity in 94 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWJ8" FT /protein_id="CAD95616.1" FT /translation="MQSRKTTSVLAAALLFCGLLGPGTAPPATGGGPACRPAELFATDN FT TTDGFELPAVATIALTGTVVTGSTLVDGVFWSNERQQIGYERSREFHLCVVDAPTLHNA FT AEALHRQFNQEAVLTFDYLPQNAPEADAILITVPDIGIARFRDAFASDLAAHHRLRGGS FT VTTADHTLILVAGNGDLDVARRLVEEAGGDWNATTIAHGRREFVN" FT CDS complement(13838..15415) FT /transl_table=11 FT /gene="guaA" FT /locus_tag="Mb3429c" FT /product="PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] FT GUAA (GLUTAMINE AMIDOTRANSFERASE) (GMP SYNTHETASE)" FT /EC_number="6.3.5.2" FT /note="Mb3429c, guaA, len: 525 aa. Equivalent to Rv3396c, FT len: 525 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 525 aa overlap). Probable guaA, gmp FT synthase (EC 6.3.5.2) (see citation below), equivalent to FT P46810|GUAA_MYCLE|ML0395|B1620_C2_205 GMP SYNTHASE FT [GLUTAMINE-HYDROLYZING] from Mycobacterium leprae (529 aa), FT FASTA scores: opt: 2992, E(): 8.5e-168, (86.85% identity in FT 525 aa overlap). Also highly similar to others e.g. FT O52831|GUAA_CORAM from Corynebacterium ammoniagenes FT (Brevibacterium ammoniagenes) (524 aa), FASTA scores: opt: FT 2636, E(): 5.9e-147, (76.2% identity in 521 aa overlap); FT Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526 aa), FT FASTA scores: opt: 2451, E(): 4.1e-136, (71.55% identity in FT 513 aa overlap); Q9KF78|GUAA_BACHD from Bacillus Halodurans FT (513 aa), FASTA scores: opt: 1819, E(): 4.1e-99, (52.55% FT identity in 510 aa overlap); etc. Contains PS00442 FT Glutamine amidotransferases class-I active site. BELONGS TO FT THE TYPE-1 GLUTAMINE AMIDOTRANSFERASE FAMILY IN THE FT N-TERMINAL SECTION. AND BELONGS TO THE GMP SYNTHASE FAMILY FT IN THE C-TERMINAL SECTION." FT /db_xref="GOA:P0A5A2" FT /db_xref="HSSP:1GPM" FT /db_xref="InterPro:IPR001317" FT /db_xref="UniProtKB/Swiss-Prot:P0A5A2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95617.1" FT /translation="MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIP FT HTASIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQALG FT GIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAGAPV FT AAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQ FT IGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGA FT NLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYP FT DVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVAR FT QPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVG FT VQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSK FT PPATIEWE" FT CDS complement(15427..16335) FT /transl_table=11 FT /gene="phyA" FT /locus_tag="Mb3430c" FT /standard_name="crtB" FT /product="PROBABLE PHYTOENE SYNTHASE PHYA" FT /EC_number="2.5.1.-" FT /note="Mb3430c, phyA, len: 302 aa. Equivalent to Rv3397c, FT len: 302 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 302 aa overlap). Probable phyA FT (alternate gene name: crtB), phytoene synthase (EC FT 2.5.1.-), similar to many e.g. Q9X7V5|SC6A5.09 from FT Streptomyces coelicolor (312 aa), FASTA scores: opt: 791, FT E(): 2.8e-43, (48.25% identity in 286 aa overlap); FT Q9RW07|DR0862 from Deinococcus radiodurans (325 aa), FASTA FT scores: opt: 482, E(): 1.5e-23, (35.25% identity in 292 aa FT overlap); Q9JRU9|NMB1168|NMB1130 from Neisseria FT meningitidis (serogroup B) (290 aa), FASTA scores: opt: FT 446, E(): 2.8e-21, (34.25% identity in 260 aa overlap); FT P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419 FT aa), FASTA scores: opt: 431, E(): 3.4e-20, (33.0% identity FT in 288 aa overlap); etc. Also similar to Q9JUF5|NMA1339 FT PUTATIVE POLY-ISOPRENYL TRANSFERASE (EC 2.5.1.) from FT Neisseria meningitidis (serogroup A) (290 aa), FASTA FT scores: opt: 450, E(): 1.6e-21, (34.6% identity in 260 aa FT overlap). Contains PS01045 Squalene and phytoene synthases FT signature 2. BELONGS TO THE PHYTOENE/SQUALENE SYNTHETASE FT FAMILY." FT /db_xref="GOA:P65861" FT /db_xref="InterPro:IPR008949" FT /db_xref="UniProtKB/Swiss-Prot:P65861" FT /protein_id="CAD95618.1" FT /translation="MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGR FT RIDDVADGELAPETKITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELID FT GARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQTNI FT LRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSL FT GLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS FT SVTCGPAHGPLPADLGSHPSH" FT CDS complement(16364..17443) FT /transl_table=11 FT /gene="idsA1" FT /locus_tag="Mb3431c" FT /standard_name="idsA" FT /product="PROBABLE MULTIFUNCTIONAL GERANYLGERANYL FT PYROPHOSPHATE SYNTHETASE IDSA1 (GGPP SYNTHETASE) (GGPPSASE) FT (GERANYLGERANYL DIPHOSPHATE SYNTHASE): FT DIMETHYLALLYLTRANSFERASE (PRENYLTRANSFERASE) FT (GERANYL-DIPHOSPHATE SYNTHASE) + GERANYLTRANSTRANSFERASE FT (FARNESYL-DIPHOSPHATE SYNTHASE) (FARNESYL-PYROPHOSPHATE FT SYNTHETASE) (FARNESYL DIPHOSPHATE SYNTHETASE) (FPP FT SYNTHETASE) + FARNESYLTRANSTRANSFERASE FT (GERANYLGERANYL-DIPHOSPHATE SYNTHASE)" FT /EC_number="2.5.1.1" FT /EC_number="2.5.1.10" FT /EC_number="2.5.1.29" FT /note="Mb3431c, idsA1, len: 359 aa. Equivalent to Rv3398c, FT len: 359 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 359 aa overlap). Probable idsA1, FT geranylgeranyl pyrophosphate synthetase (GGPP synthetase) FT including: dimethylallyltransferase (EC 2.5.1.1), FT geranyltranstransferase (EC 2.5.1.10), and FT farnesyltranstransferase (EC 2.5.1.29). Most similar to FT AE000797_3|O26156|Q53479 bifunctional short chain isoprenyl FT diphosphate synthase from Methanobacterium thermoautotrop FT (325 aa), FASTA scores: opt: 605, E(): 0, (37.1% identity FT in 329 aa overlap); homology suggests ATG at 30121 or TTG FT at 30145 to be the initiation codon. Contains PS00444 FT Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP FT SYNTHETASES FAMILY; BELONGS TO A FAMILY THAT GROUPS FT TOGETHER FPP SYNTHETASE, GGPP SYNTHETASE AND HEXAPRENYL FT PYROPHOSPHATE SYNTHETASE. Note that previously known as FT idsA." FT /db_xref="GOA:P0A5H9" FT /db_xref="InterPro:IPR008949" FT /db_xref="UniProtKB/Swiss-Prot:P0A5H9" FT /protein_id="CAD95619.1" FT /translation="MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRL FT DPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELV FT HNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAAL FT RAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRS FT VREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSA FT GRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIP FT DRPAAELQDLAHYIVDRQA" FT CDS 17466..18512 FT /transl_table=11 FT /gene="Mb3432" FT /locus_tag="Mb3432" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3432, -, len: 348 aa. Equivalent to Rv3399, len: FT 348 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 348 aa overlap). Hypothetical protein, FT similar to other Mycobacterium tuberculosis (strains H37Rv FT and CDC1551) hypothetical proteins e.g. FT P95074|Rv0726c|MTCY210.45c (367 aa), FASTA scores: opt: FT 1188, E(): 7.7e-69, (60.05% identity in 308 aa overlap); FT MTCY31.21c (38.0% identity in 308 aa overlap), MTV041_5, FT MTCY4C12_14, MTY13D12_21, MTV043_22, MTCY210_44, MTCI5_19, FT MTCI5_20, MTV035_9, MTCY180_22, MTCY31_23, MTY13D12_1, FT MTCY180_29; etc." FT /db_xref="GOA:P59986" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/Swiss-Prot:P59986" FT /protein_id="CAD95620.1" FT /translation="MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMTR FT TDNDTWDLASSVGATATMIATARALASRAENPLINDPFAEPLVRAVGIDLFTRLASGEL FT RLEDIGDHATGGRWMIDNIAIRTKFYDDFFGDATTAGIRQVVILAAGLDTRAYRLPWPP FT GTVVYEIDQPAVIKFKTRALANLNAEPNAERHAVAVDLRNDWPTALKNAGFDPARPTAF FT SAEGLLSYLPPQGQDRLLDAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSAAEAWR FT ERGFDLDLTELIYFDQRNDVADYLAGSGWQVTTSTGKELFAAQGLPPFEDDHITRFADR FT RYISAVLK" FT CDS 18576..19364 FT /transl_table=11 FT /gene="Mb3433" FT /locus_tag="Mb3433" FT /product="PROBABLE HYDROLASE" FT /EC_number="3.-.-.-" FT /note="Mb3433, -, len: 262 aa. Equivalent to Rv3400, len: FT 262 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 262 aa overlap). Probable hydrolase (EC FT 3.-.-.-), strongly equivalent to FT Q49741|YY00_MYCLE|ML0393|B1620_F3_119 HYPOTHETICAL 28.6 KDA FT PROTEIN from Mycobacterium leprae (261 aa), FASTA scores: FT opt: 1293, E(): 2.2e-71, (74.45% identity in 262 aa FT overlap). Similar to several various proteins (notably FT hydrolases) e.g. Q9L2I7|SCF42.32 PUTATIVE HYDROLASE from FT Streptomyces coelicolor (246 aa), FASTA scores: opt: 888, FT E(): 7.7e-47, (56.35% identity in 245 aa overlap); FT Q9EX06|2SCG38.13 PUTATIVE HYDROLASE from Streptomyces FT coelicolor (238 aa), FASTA scores: opt: 195, E(): 8.1e-05, FT (29.5% identity in 234 aa overlap); Q9I5X4|PA0562 PROBABLE FT HYDROLASE from Pseudomonas aeruginosa (224 aa), FASTA FT scores: opt: 190, E(): 0.00015, (27.8% identity in 248 aa FT overlap); O06995|PGMB_BACSU|YVDM PUTATIVE FT BETA-PHOSPHOGLUCOMUTASE from Bacillus subtilis (226 aa), FT FASTA scores: opt: 190, E(): 0.00016, (33.9% identity in FT 245 aa overlap); etc. Also similar to Mycobacterium FT tuberculosis hypothetical protein FT Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa), FASTA FT scores: opt: 413, E(): 2e-17, (34.9% identity in 238 aa FT overlap). Interestingly, note that Rv3400 and Rv3401 are FT similar to beginning and end of FT Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 FT aa missing from the middle." FT /db_xref="GOA:P65070" FT /db_xref="HSSP:1O08" FT /db_xref="InterPro:IPR006402" FT /db_xref="UniProtKB/Swiss-Prot:P65070" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95621.1" FT /translation="MANWYRPNYPEVRSRVLGLPEKVRACLFDLDGVLTDTASLHTKAW FT KAMFDAYLAERAERTGEKFVPFDPAADYHTYVDGKKREDGVRSFLSSRAIEIPDGSPDD FT PGAAETVYGLGNRKNDMLHKLLRDDGAQVFDGSRRYLEAVTAAGLGVAVVSSSANTRDV FT LATTGLDRFVQQRVDGVTLREEHIAGKPAPDSFLRAAELLGVTPDAAAVFEDALSGVAA FT GRAGNFAVVVGINRTGRAAQAAQLRRHGADVVVTDLAELL" FT CDS 19379..21739 FT /transl_table=11 FT /gene="Mb3434" FT /locus_tag="Mb3434" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3434, -, len: 786 aa. Equivalent to Rv3401, len: FT 786 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 786 aa overlap). Hypothetical conserved FT protein, may be an hydrolase or a transferase, equivalent FT to Q49736|ML0392|B1620_F1_30 HYPOTHETICAL 88.1 KDA PROTEIN FT from Mycobacterium leprae (792 aa), FASTA scores: opt: FT 4820, E(): 0, (91.45% identity in 782 aa overlap). Also FT highly similar to Q9L2I8|SCF42.31c PUTATIVE GLYCOSYL FT TRANSFERASE from Streptomyces coelicolor (792 aa), FASTA FT scores: opt: 3060, E(): 2.9e-179, (59.25% identity in 785 FT aa overlap); and similar to others e.g. Q9K109|NMB0390 FT MALTOSE PHOSPHORYLASE from Neisseria meningitidis FT (serogroup B) (752 aa), FASTA scores: opt: 980, E(): FT 3.5e-52, (29.2% identity in 774 aa overlap); FT Q9JSW8|MAPA|NMA2098 PUTATIVE MALTOSE PHOSPHORYLASE (EC FT 2.4.1.8) from Neisseria meningitidis (serogroup A) (752 FT aa), FASTA scores: opt: 956, E(): 1e-50, (28.4% identity in FT 764 aa overlap); O06993|YVDK_BACSU HYPOTHETICAL 88.3 KDA FT PROTEIN (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from FT Bacillus subtilis (757 aa), FASTA scores: opt: 926, E(): FT 6.9e-49, (28.5% identity in 754 aa overlap); Q9CF04|MAPA FT MALTOSEPHOSPHORYLASE from Lactococcus lactis (subsp. FT lactis) (Streptococcus lactis) (751 aa), FASTA scores: opt: FT 907, E(): 1e-47, (26.95% identity in 753 aa overlap); FT P77154|YCJT_ECOLI|B1316 HYPOTHETICAL 84.9 KDA PROTEIN FT (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from FT Escherichia coli strain K12 (755 aa), FASTA scores: opt: FT 392, E(): 2.9e-16, (27.5% identity in 774 aa overlap); etc. FT Also similar to Mycobacterium tuberculosis hypothetical FT protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 FT aa), (27.2% identity in 802 aa overlap); note that Rv3400 FT and Rv3401 are similar to beginning and end of FT Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 FT aa missing from the middle." FT /db_xref="GOA:Q7TWJ7" FT /db_xref="InterPro:IPR017045" FT /db_xref="UniProtKB/TrEMBL:Q7TWJ7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95622.1" FT /translation="MITEDAFPVEPWQVRETKLNLNLLAQSESLFALSNGHIGLRGNLD FT EGEPFGLPGTYLNSFYEIRPLPYAEAGYGYPEAGQTVVDVTNGKIFRLLVGDEPFDVRY FT GELISHERILDLRAGTLTRRAHWRSPAGKQVKVTSTRLVSLAHRSVAAIEYVVEAIEEF FT VRVTVQSELVTNEDVPETSADPRVSAILDRPLQAVEHERTERGALLMHRTRASALMMAA FT GMEHEVEVPGRVEITTDARPDLARTTVICGLRPGQKLRIVKYLAYGWSSLRSRPALRDQ FT AAGALHGARYSGWQGLLDAQRAYLDDFWDSADVEVEGDPECQQAVRFGLFHLLQASARA FT ERRAIPSKGLTGTGYDGHAFWDTEGFVLPVLTYTAPHAVADALRWRASTLDLAKERAAE FT LGLEGAAFPWRTIRGQESSAYWPAGTAAWHINADIAMAFERYRIVTGDGSLEEECGLAV FT LIETARLWLSLGHHDRHGVWHLDGVTGPDEYTAVVRDNVFTNLMAAHNLHTAADACLRH FT PEAAEAMGVTTEEMAAWRDAADAANIPYDEELGVHQQCEGFTTLAEWDFEANTTYPLLL FT HEAYVRLYPAQVIKQADLVLAMQWQSHAFTPEQKARNVDYYERRMVRDSSLSACTQAVM FT CAEVGHLELAHDYAYEAALIDLHDLHRNTRDGLHMASLAGAWTALVVGFGGLRDDEGIL FT SIDPQLPDGISRLRFRLRWRGFRLIVDANHTDVTFILGDGPGTQLTMRHAGQDLTLHTD FT TPSTIAVRTRKPLLPPPPQPPGREPVHRRALAR" FT CDS complement(22467..23519) FT /transl_table=11 FT /gene="Mb3436c" FT /locus_tag="Mb3436c" FT /product="CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]" FT /note="Mb3436c, -, len: 350 aa. Equivalent to 5' end of FT Rv3402c, len: 412 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.7% identity in 350 aa overlap). Conserved FT hypothetical protein, probably involved in cell process, FT similar to various proteins generally involved in FT extracellular compounds (lipopolysaccharide O-antigen) FT biosynthesis e.g. O68392|RFBE PEROSAMINE SYNTHETASE from FT Brucella melitensis (367 aa), FASTA scores: opt: 420, E(): FT 1.2e-19, (26.15% identity in 375 aa overlap); Q9L6C1 FT 3,4-DEHYDRATASE-LIKE PROTEIN from Streptomyces antibioticus FT (393 aa), FASTA scores: opt: 419, E(): 1.5e-19, (30.65% FT identity in 385 aa overlap); Q9RR26|OLENI DEHYDRATASE from FT Streptomyces antibioticus (393 aa), FASTA scores: opt: 416, FT E(): 2.3e-19, (30.65% identity in 385 aa overlap); O33942 FT ERYCIV PROTEIN from Saccharopolyspora erythraea FT (Streptomyces erythraeus) (401 aa), FASTA scores: opt: 410, FT E(): 5.6e-19, (31.75% identity in 362 aa overlap); FT Q9UZI4|ASPB-LIKE1|PAB0774 ASPARTATE AMINOTRANSFERASE FT (ASPB-LIKE1) from Pyrococcus abyssi (366 aa), FASTA scores: FT opt: 402, E(): 1.7e-18, (27.05% identity in 377 aa FT overlap); O88001|WLBC PUTATIVE AMINO-SUGAR BIOSYNTHESIS FT PROTEIN from Bordetella bronchiseptica (Alcaligenes FT bronchisepticus) (366 aa), FASTA scores: opt: 394, E(): FT 5.6e-18, (26.8% identity in 347 aa overlap); Q45378|BPLC FT DNA FOR LIPOPOLYSACCHARIDE BIOSYNTHESIS from Bordetella FT pertussis (366 aa), FASTA scores: opt: 393, E(): 6.5e-18, FT (26.8% identity in 347 aa overlap); etc. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT single base transversion (c-g) leads to a shorter product." FT /db_xref="GOA:Q7TWJ6" FT /db_xref="InterPro:IPR015422" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWJ6" FT /protein_id="CAD95623.1" FT /translation="MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSF FT PGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHV FT SFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSACAVIERFRDR FT IAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFS FT FHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLR FT QLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSL FT RRHAIEARDY" FT CDS complement(23890..25491) FT /transl_table=11 FT /gene="Mb3437c" FT /locus_tag="Mb3437c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3437c, -, len: 533 aa. Equivalent to Rv3403c, len: FT 533 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 533 aa overlap). Hypothetical unknown FT protein, but some weak similarity to Q9KJP2 HYPOTHETICAL FT 54.9 KDA PROTEIN from Myxococcus xanthus (504 aa), FASTA FT scores: opt: 157, E(): 0.011, (24.1% identity in 548 aa FT overlap)." FT /db_xref="GOA:P65072" FT /db_xref="UniProtKB/Swiss-Prot:P65072" FT /protein_id="CAD95624.1" FT /translation="MLAFPYLMTMITPPTFDVAFIGSGAACSMTLLEMADALLSSPSAS FT PKLRIAVVERDEQFWCGIPYGQRSSIGSLAIQKLDDFADEPEKAAYRIWLEQNKQRWLA FT FFQAEGGAAAARWICDNRDALDGNQWGELYLPRFLFGVFLSEQMIAAIAALGERDLAEI FT VTIRAEAMSAHSADGHYRIGLRPSGNGPTAIAAGKVVVAIGSPPTKAILASDSEPAFTY FT INDFYSPGGESNVARLRDSLDRVESWEKRNVLVVGSNATSLEALYLMRHDARIRARVRS FT ITVISRSGVLPYMICNQPPEFDFPRLRTLLCTEAIAAADLMSAIRDDLATAEERSLNLA FT DLYDAVAALFGQALHKMDLVQQEEFFCVHGMNFTKLVRRAGRDCRQASEELAADGTLSL FT LAGEVLRVDACASGQPFATMTYRAAGAEHTHPVPFAAVVNCGGFEELDTCSSPFLVSAM FT QNGLCRPNRTNRGLLVNDDFEASPGFCVIGPLVGGNFTPKIRFWHVESAPRVRSLAKSL FT AASLLASLQPVALAPC" FT CDS complement(25508..26212) FT /transl_table=11 FT /gene="Mb3438c" FT /locus_tag="Mb3438c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3438c, -, len: 234 aa. Equivalent to Rv3404c, len: FT 234 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 234 aa overlap). Conserved hypothetical FT protein, some similarity to several METHIONYL-TRNA FT FORMYLTRANSFERASES e.g. BAB51418|MLL4854 from Rhizobium FT loti (Mesorhizobium loti) (317 aa), FASTA scores: opt: 210, FT E(): 1.7e-06, (27.55% identity in 178 aa overlap); FT P94463|FMT_BACSU from Bacillus subtilis (317 aa), FASTA FT scores: opt: 199 ,E(): 8.8e-06, (28.25% identity in 177 aa FT overlap); O51091||FMT_BORBU|BB0064 from Borrelia FT burgdorferi (Lyme disease spirochete) (312 aa), FASTA FT scores: opt: 187, E(): 5.2e-05, (30.2% identity in 192 aa FT overlap); etc." FT /db_xref="GOA:P65074" FT /db_xref="InterPro:IPR015518" FT /db_xref="UniProtKB/Swiss-Prot:P65074" FT /protein_id="CAD95625.1" FT /translation="MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVA FT ERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKV FT GVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTA FT KSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFV FT RVVLEPEKPAEA" FT CDS complement(26330..26896) FT /transl_table=11 FT /gene="Mb3439c" FT /locus_tag="Mb3439c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb3439c, -, len: 188 aa. Equivalent to Rv3405c, len: FT 188 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 188 aa overlap). Possible FT transcriptional regulator, showing weak similarity to other FT bacterial regulatory proteins e.g. Q9KE70|BH0987 from FT Bacillus halodurans (203 aa), FASTA scores: opt: 168, E(): FT 0.0016, (34.8% identity in 92 aa overlap); Q9A5F7|CC2493 FT Caulobacter crescentus (204 aa), FASTA scores: opt: 160, FT E(): 0.0051, (32.6% identity in 89 aa overlap); FT Q9RDR0|SC4A7.02 from Streptomyces coelicolor (227 aa), FT FASTA scores: opt: 159, E(): 0.0064, (37.0% identity in 189 FT aa overlap); etc. Also some similarity to hypothetical FT Mycobacterium tuberculosis regulatory proteins e.g. FT O05858|Rv3208|MTCY07D11.18c, MTCI125_6, MTCY7D11_18, FT MTCY10G2_30; etc. Contains potential helix-turn-helix motif FT from aa 39-60 (+2.97 SD)." FT /db_xref="GOA:P67443" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:P67443" FT /protein_id="CAD95626.1" FT /translation="MTTRPATDRRKMPTGREEVAAAILQAATDLFAERGPAATSIRDIA FT ARSKVNHGLVFRHFGTKDQLVGAVLDHLGTKLTRLLHSEAPADIIERALDRHGRVLARA FT LLDGYPVGQLQQRFPNVAELLDAVRPRYDSDLGARLAVAHALALQFGWRLFAPMLRSAT FT GIDELTGDELRLSVNDAVARILEPH" FT CDS 26958..27845 FT /transl_table=11 FT /gene="Mb3440" FT /locus_tag="Mb3440" FT /product="PROBABLE DIOXYGENASE" FT /EC_number="1.-.-.-" FT /note="Mb3440, -, len: 295 aa. Equivalent to Rv3406, len: FT 295 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 295 aa overlap). Probable dioxygenase FT (EC 1.-.-.-), highly similar to Q9WWU|ATSK PUTATIVE FT ALPHA-KETOGLUTARATE DEPENDENT DIOXYGENASE from Pseudomonas FT putida (301 aa), FASTA scores: opt: 994, E(): 3.9e-57, FT (53.7% identity in 283 aa overlap); Q9I6U1|PA0193 FT HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa), FT FASTA scores: opt: 1024, E(): 4.4e-59, (53.65% identity in FT 287 aa overlap); Q9HX81|TAUD|PA3935 TAURINE DIOXYGENASE FT from Pseudomonas aeruginosa (277 aa), FASTA scores: opt: FT 599, E(): 1.4e-31, (39.35% identity in 277 aa overlap); and FT similar to other dioxygenases e.g. AAG54718|TAUD (alias FT BAB33845|ECS0422) TAURINE DIOXYGENASE FT 2-OXOGLUTARATE-DEPENDENT from Escherichia coli strain FT O157:H7 (283 aa), FASTA scores: opt: 595, E(): 2.5e-31, FT (38.1% identity in 281 aa overlap); etc. BELONGS TO THE FT TFDA FAMILY OF DIOXYGENASES." FT /db_xref="GOA:P65076" FT /db_xref="HSSP:1GY9" FT /db_xref="InterPro:IPR003819" FT /db_xref="UniProtKB/Swiss-Prot:P65076" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95627.1" FT /translation="MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVV FT FFRGQHQLDDAEQLAFAGLLGTPIGHPAAIALADDAPIITPINSEFGKANRWHTDVTFA FT ANYPAASVLRAVSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKP FT LTAAQRAFRQVFEKPDFRTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVL FT QRRITMPENTIRWNWAPGDVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQ FT ASRVISGAPMEIAG" FT CDS 27880..28179 FT /transl_table=11 FT /gene="Mb3441" FT /locus_tag="Mb3441" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3441, -, len: 99 aa. Equivalent to Rv3407, len: 99 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 99 aa overlap). Hypothetical protein, similar FT to other hypothetical proteins from M. tuberculosis strains FT H37Rv and CDC1551 e.g. AAK46285|MT2013 (90 aa), FASTA FT scores: opt: 160, E(): 0.00021, (37.1% identity in 89 aa FT overlap); O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: FT opt: 155, E(): 0.00051, (41.05% identity in 78 aa overlap), FT MTCY19H5.26, MTCY20H10.07, MTI376.09c, MTCY427.21, etc." FT /db_xref="InterPro:IPR006442" FT /db_xref="UniProtKB/Swiss-Prot:P65078" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95628.1" FT /translation="MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARL FT IPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRTLSDVLNEMRDEQ" FT CDS 28176..28586 FT /transl_table=11 FT /gene="Mb3442" FT /locus_tag="Mb3442" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3442, -, len: 136 aa. Equivalent to Rv3408, len: FT 136 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 136 aa overlap). Hypothetical protein, FT similar to other hypothetical proteins from M. tuberculosis FT strains H37Rv and CDC1551 e.g. O50411|Rv3384c|MTV004.42c FT (130 aa), FASTA scores: opt: 243, E(): 1.7e-09, (35.1% FT identity in 131 aa overlap); P95252|Rv1962c|MTCY09F9.02 FT (135 aa), FASTA scores: opt: 191, E(): 5e-06, (35.5% FT identity in 138 aa overlap), etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:Q7TWJ5" FT /protein_id="CAD95629.1" FT /translation="MIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVE FT LMRVVARYGQPGQTERARYLLDGLDILPLTEPVIGLAETIGPATLRSLDAIHLAAAAQI FT KRELTAFVTYDHRLLSGCREVGFVTASPGAVR" FT CDS complement(28619..30355) FT /transl_table=11 FT /gene="choD" FT /locus_tag="Mb3443c" FT /product="PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD FT (CHOLESTEROL-O2 OXIDOREDUCTASE)" FT /EC_number="1.1.3.6" FT /note="Mb3443c, choD, len: 578 aa. Equivalent to Rv3409c, FT len: 578 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 578 aa overlap). Probable choD, FT cholesterol oxidase precursor (EC 1.1.3.6), equivalent to FT Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240) FT PUTATIVE CHOLESTEROL OXIDASE from Mycobacterium leprae (569 FT aa), FASTA scores: opt: 3510, E(): 3.8e-198, (88.6% FT identity in 569 aa overlap). Also highly similar to FT Q9L0H6|SCD63.13 PUTATIVE CHOLESTEROL OXIDASE from FT Streptomyces coelicolor (602 aa), FASTA scores: opt: 1101, FT E(): 5.2e-57, (60.05% identity in 586 aa overlap); and FT similar to other oxidoreductases e.g. Q9A7T6|CC1634 FT OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus FT (579 aa), FASTA scores: opt: 221, E(): 1.8e-05, (25.2% FT identity in 583 aa overlap). BELONGS TO THE GMC FT OXIDOREDUCTASES FAMILY. COFACTOR: FAD FLAVOPROTEIN. FT Contains PS00017 ATP/GTP-binding site motif A." FT /db_xref="GOA:Q7TWJ4" FT /db_xref="HSSP:1COY" FT /db_xref="InterPro:IPR006076" FT /db_xref="UniProtKB/TrEMBL:Q7TWJ4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95630.1" FT /translation="MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEFA FT KTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLNYANTLYVPPEPFFADQ FT QWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRIVKEVADEMGFGDTWVPTPVGVF FT FGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGA FT QVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMR FT DRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEPVR FT YGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQWSERTVIA FT LVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIPIGNQVTRRIAAKIDGVAGGT FT WGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLS FT IAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSN FT AG" FT CDS complement(30411..31538) FT /transl_table=11 FT /gene="guaB3" FT /locus_tag="Mb3444c" FT /product="PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE FT GUAB3 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) FT (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) FT (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD)" FT /EC_number="1.1.1.205" FT /note="Mb3444c, guaB3, len: 375 aa. Equivalent to Rv3410c, FT len: 375 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 375 aa overlap). Probable guaB3, FT inosine-5'-monophosphate (IMP) dehydrogenase (EC FT 1.1.1.205), equivalent to FT Q49721|YY10_MYCLE|ML0388|B1620_C2_193 HYPOTHETICAL 38.9 KDA FT PROTEIN from Mycobacterium leprae (375 aa), FASTA scores: FT opt: 2182, E(): 9.5e-122, (90.6% identity in 373 aa FT overlap). Highly similar to Q9RHY9 GUAB ORF GENES FOR IMP FT DEHYDROGENASE, HYPOTHETICAL PROTEIN from Corynebacterium FT ammoniagenes (Brevibacterium ammoniagenes) (376 aa), FASTA FT scores: opt: 1490, E(): 7.6e-81, (61.0% identity in 382 aa FT overlap); Q9L0I6|SCD63.03 PUTATIVE INOSINE-5'-MONOPHOSPHATE FT DEHYDROGENASE from Streptomyces coelicolor (374 aa), FASTA FT scores: opt: 1275, E(): 3.8e-68, (52.95% identity in 372 aa FT overlap); P73853|GUAB|SLR1722 IMP DEHYDROGENASE SUBUNIT FT from Synechocystis sp. strain PCC 6803 (387 aa), FASTA FT scores: opt: 882, E(): 6.7e-45, (41.3% identity in 373 aa FT overlap); and similar to other inosine-5'-monophosphate FT dehydrogenases e.g. P44334|IMDH_HAEIN|GUAB|HI0221 from FT Haemophilus influenzae (488 aa), FASTA scores: opt: 267, FT E(): 1.8e-08, (34.25% identity in 216 aa overlap); etc. FT Also highly similar to the C-terminus of Q50753|GUAA/B FT HOMOLOGY TO Mycobacterium leprae GUAA (FRAGMENT) from FT Mycobacterium tuberculosis (130 aa), FASTA scores: opt: FT 506, E(): 4.6e-23, (85.05% identity in 87 aa overlap). FT SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO FT GMP REDUCTASE." FT /db_xref="GOA:P65171" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR005992" FT /db_xref="UniProtKB/Swiss-Prot:P65171" FT /protein_id="CAD95631.1" FT /translation="MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFE FT IPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPS FT TAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVI FT QGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGST FT QGVTTTDEVLGISVPMATAIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIAC FT GADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDD FT PFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG" FT CDS complement(31558..33147) FT /transl_table=11 FT /gene="guaB2" FT /locus_tag="Mb3445c" FT /product="PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE FT GUAB2 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) FT (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) FT (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD)" FT /EC_number="1.1.1.205" FT /note="Mb3445c, guaB2, len: 529 aa. Equivalent to Rv3411c, FT len: 529 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 529 aa overlap). Probable guaB2, FT inosine-5'-monophosphate (IMP) dehydrogenase (EC FT 1.1.1.205), equivalent to FT Q49729|IMDH_MYCLE|GUAB|ML0387|B1620_C3_238 FT INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE from Mycobacterium FT leprae (529 aa), FASTA scores: opt: 3154, E(): 4.4e-165, FT (92.45% identity in 529 aa overlap). Highly similar to FT other inosine-5'-monophosphate dehydrogenases e.g. FT Q9RHZ0|GUAB from Corynebacterium ammoniagenes FT (Brevibacterium ammoniagenes) (506 aa), FASTA scores: opt: FT 2284, E(): 1.5e-117, (67.9% identity in 505 aa overlap); FT Q9L0I7|SCD63.02 from Streptomyces coelicolor (501 aa), FT FASTA scores: opt: 2178, E(): 9e-112, (67.2% identity in FT 491 aa overlap); O67820|IMDH_AQUAE|GUAB|AQ_2023 from FT Aquifex aeolicus (490 aa), FASTA scores: opt: 1820, E(): FT 3.2e-92, (58.1% identity in 487 aa overlap); etc. Also FT similar to Q50716|YY10_MYCTU|Rv3410c|MT3518|MTCY78.18 FT HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium FT tuberculosis (38.6% identity in 158 aa overlap). Contains FT PS00487 IMP dehydrogenase / GMP reductase signature. FT SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO FT GMP REDUCTASE." FT /db_xref="GOA:P65168" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR018529" FT /db_xref="UniProtKB/Swiss-Prot:P65168" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95632.1" FT /translation="MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGL FT TFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMG FT VLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDD FT GALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVD FT GRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLV FT VDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSI FT CTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSL FT LAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPE FT GIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDV FT AMTVEAPNYYAR" FT CDS 33354..33764 FT /transl_table=11 FT /gene="Mb3446" FT /locus_tag="Mb3446" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3446, -, len: 136 aa. Equivalent to Rv3412, len: FT 136 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 136 aa overlap). Hypothetical protein, FT strongly similar only to FT Q49742|YY12_MYCLE|ML0386|B1620_F3_131 HYPOTHETICAL 15.3 KDA FT PROTEIN from Mycobacterium leprae (137 aa), FASTA scores: FT opt: 933, E(): 6.3e-52, (93.4% identity in 136 aa FT overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P65080" FT /protein_id="CAD95633.1" FT /translation="MRDHLPPGLPPDPFADDPCDPSAALEAVEPGQPLDQQERMAVEAD FT LADLAVYEALLAHKGIRGLVVCCDECQQDHYHDWDMLRSNLLQLLIDGTVRPHEPAYDP FT EPDSYVTWDYCRGYADASLNEAAPDADRFRRR" FT CDS complement(33774..34673) FT /transl_table=11 FT /gene="Mb3447c" FT /locus_tag="Mb3447c" FT /product="HYPOTHETICAL ALANINE AND PROLINE RICH PROTEIN" FT /note="Mb3447c, -, len: 299 aa. Equivalent to Rv3413c, len: FT 299 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 299 aa overlap). Hypothetical unknown FT ala-, pro-rich protein." FT /db_xref="GOA:P65082" FT /db_xref="UniProtKB/Swiss-Prot:P65082" FT /protein_id="CAD95634.1" FT /translation="MREFGNPLGDRPPLDELARTDLLLDALAEREEVDFADPRDDALAA FT LLGQWRDDLRWPPASALVSQDEAVAALRAGVAQRRRARRSLAAVGSVAAALLVLSGFGA FT VVADARPGDLLYGLHAMMFNRSRVSDDQIVLSAKANLAKVEQMIAQGQWAEAQDELAEV FT SSTVQAVTDGSRRQDLINEVNLLNTKVETRDPNATLRPGSPSNPAAPGSVGNSWTPLAP FT VVEPPTPPTPASAAEPSMSAGVSESPMPNSTSTVAASPSTPSSKPEPGSIDPSLEPADE FT ATNPAGQPAPETPVSPTH" FT CDS complement(34666..35304) FT /transl_table=11 FT /gene="sigD" FT /locus_tag="Mb3448c" FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA-D FT FACTOR SIGD" FT /note="Mb3448c, sigD, len: 212 aa. Equivalent to Rv3414c, FT len: 212 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 212 aa overlap). Probable sigD, FT alternative RNA polymerase sigma-D factor (see citation FT below), similar to others (notably from Streptomyces FT coelicolor) e.g. Q9L0I8|SCD63.01 from Streptomyces FT coelicolor (195 aa), FASTA scores: opt: 533, E(): 9.6e-28, FT (47.25% identity in 182 aa overlap); Q9FDS3|ADSA from FT Streptomyces griseus (258 aa), FASTA scores: opt: 223, E(): FT 1.8e-07, (28.95% identity in 183 aa overlap); FT BAB48649|MLL1224 from Rhizobium loti (Mesorhizobium loti) FT (187 aa), FASTA scores: opt: 202, E(): 3.2e-06, (30.4% FT identity in 194 aa overlap); FT P38133|RPOE_STRCO|SIGE|SCE94.07 from Streptomyces FT coelicolor (176 aa), FASTA scores: opt: 200, E(): 4.1e-06, FT (35.25% identity in 156 aa overlap); P37978|CNRH_ALCEU from FT Alcaligenes eutrophus (Ralstonia eutropha), FASTA scores: FT opt: 197, E(): 6.9e-06, (30.35% identity in 191 aa FT overlap); etc. C-terminus strongly similar to N-terminal FT part of Q49727|S1620B|B1620_C3_233 HYPOTHETICAL 6.2 KDA FT PROTEIN from Mycobacterium leprae (59 aa), FASTA scores: FT opt: 217, E(): 1.3e-07, (90.25% identity in 41 aa overlap). FT BELONGS TO THE SIGMA-70 FACTOR FAMILY." FT /db_xref="GOA:P66812" FT /db_xref="InterPro:IPR013249" FT /db_xref="UniProtKB/Swiss-Prot:P66812" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95635.1" FT /translation="MVDPGVSPGCVRFVTLEISPSMTMQGERLDAVVAEAVAGDRNALR FT EVLETIRPIVVRYCRARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYG FT IAAHKVADAHRAAGRDRAYPAETLPERWSADAGPEQMAIEADSVTRMNELLEILPAKQR FT EILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAAGDYA" FT CDS complement(35322..36149) FT /transl_table=11 FT /gene="Mb3449c" FT /locus_tag="Mb3449c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3449c, -, len: 275 aa. Equivalent to Rv3415c, len: FT 275 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 275 aa overlap). Conserved hypothetical FT protein, equivalent to Q9CCV3|ML0383 HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (281 aa), FASTA scores: opt: FT 1278, E(): 4.2e-71, (73.5% identity in 279 aa overlap); and FT Q49858|B229_C1_175 HYPOTHETICAL 27.4 KDA PROTEIN from FT Mycobacterium leprae (264 aa), FASTA scores: opt: 1186, FT E(): 1.7e-65, (74.05% identity in 258 aa overlap). And FT C-terminus highly similar to N-terminal part of FT Q49726|B1620_C3_232 HYPOTHETICAL 12.9 KDA PROTEIN from FT Mycobacterium leprae (122 aa), FASTA scores: opt: 580, E(): FT 1.1e-28, (74.6% identity in 126 aa overlap). Also some FT similarity with FT P71677|RIBD_MYCTU|RIBG|Rv1409|MT1453|MTCY21B4.26 RIBOFLAVIN FT BIOSYNTHESIS PROTEIN R (339 aa), FASTA scores: opt: 143, FT E(): 0.13, (28.25% identity in 184 aa overlap)." FT /db_xref="InterPro:IPR011717" FT /db_xref="UniProtKB/TrEMBL:Q7TWJ3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95636.1" FT /translation="MNETPHAPVVEQVLVAAAFGNQPGSWPLPTAITPHHLWLRAVAAG FT GQGRYAHAYGDLSVLRRLVPAGPLASLAHSTQGSLLRQLGWHTLARGWDGRALALAGAD FT REAGADALIGLAADALGVGRFAAAGALLDRADPLVVSPLVADRLAVRRRWVAAELAMAT FT GDGATAVRHAEEAVELTQAMAVASARHRVKSDVVLAAALCSAGAVARARAVGEEALDAT FT ARFGLLPLRWALACLLIDIGTVTFSAQQLRELTKIRNICAGQVRRAGGCWRTA" FT CDS 36520..36828 FT /transl_table=11 FT /gene="whiB3" FT /locus_tag="Mb3450" FT /standard_name="whmB" FT /product="TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE FT WHIB3" FT /note="Mb3450, whiB3, len: 102 aa. Equivalent to Rv3416, FT len: 102 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 102 aa overlap). whiB3 (alternate gene FT name: whmB), WhiB-like regulatory protein (see citations FT below), similar to WhiB paralogue of Streptomyces FT coelicolor, wblE gene product (85 aa). Equivalent to FT Q49871|WHIB3|WHIB|ML0382|B229_F1_2|B1620_F3_137 PROBABLE FT TRANSCRIPTION FACTOR WHIB3 from Mycobacterium leprae (102 FT aa), FASTA scores: opt: 657, E(): 7.9e-39, (86.25% identity FT in 102 aa overlap). Also highly similar to Q9Z6E9|WHIB3 FT from Mycobacterium smegmatis (96 aa), FASTA scores: opt: FT 604, E(): 3.5e-35, (80.4% identity in 102 aa overlap); and FT O88103|WHID|SC6G4.45c|WBLB from Streptomyces coelicolor FT (112 aa), FASTA scores: opt: 437, E(): 1.4e-23, (62.5% FT identity in 96 aa overlap). Also similar to FT O05847|WHIB1|Rv3219|MTCY07D11.07c from Mycobacterium FT tuberculosis (84 aa), FASTA scores: opt: 215, E(): 2.5e-08, FT (44.45% identity in 81 aa overlap). Note that primer FT extension analysis revealed three transcriptional start FT sites and that expression from the three potential FT promoters is growth phase-dependent (see third citation)." FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q7TWJ2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95637.1" FT /translation="MPQPEQLPGPNADIWNWQLQGLCRGMDSSMFFHPDGERGRARTQR FT EQRAKEMCRRCPVIEACRSHALEVGEPYGVWGGLSESERDLLLKGTMGRTRGIRRTA" FT CDS complement(36900..38519) FT /transl_table=11 FT /gene="groEL1" FT /locus_tag="Mb3451c" FT /standard_name="cpn60_1" FT /product="60 KDA CHAPERONIN 1 GROEL1 (PROTEIN CPN60-1) FT (GROEL PROTEIN 1)" FT /note="Mb3451c, groEL1, len: 539 aa. Equivalent to Rv3417c, FT len: 539 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 539 aa overlap). groEL1 (alternate FT genbe name: cpn60_1), 60 kd chaperonin 1 (protein cpn60 1) FT (see citations below), equivalent to FT P37578|CH61_MYCLE|B1620_C3_228|GROL1|GROEL1|GROEL-1|GROE1|M FT L0381|B229_ 60 KDA CHAPERONIN 1 from Mycobacterium leprae FT (537 aa), FASTA scores: opt: 2846, E(): 1.5e-154, (82.95% FT identity in 539 aa overlap). Also highly similar to others FT e.g. Q00767|CH61_STRAL|GROL1|GROEL1 from Streptomyces albus FT G (539 aa), FASTA scores: opt: 2130, E(): 8.1e-114, (61.9% FT identity in 541 aa overlap); FT P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces FT coelicolor (540 aa), FASTA scores: opt: 2119, E(): FT 3.4e-113, (61.8% identity in 542 aa overlap); etc. Also FT similar to FT P06806|CH62_MYCTU|Q48931|Rv0440|MTV037.04|GROL2|GROEL2|GROE FT L-2|HSP65 (62.2% identity in 527 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A, PS00296 Chaperonins FT cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY." FT /db_xref="GOA:P0A519" FT /db_xref="HSSP:1IOK" FT /db_xref="InterPro:IPR002423" FT /db_xref="UniProtKB/Swiss-Prot:P0A519" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95638.1" FT /translation="MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGG FT PTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLR FT LVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEA FT MSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQ FT DKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGD FT RRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAV FT ANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVA FT AAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANA FT GLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTT FT ETVVVDKPAKAEDHDHHHGHAH" FT CDS complement(38614..38916) FT /transl_table=11 FT /gene="groES" FT /locus_tag="Mb3452c" FT /standard_name="cpn10; mpt57" FT /product="10 KDA CHAPERONIN GROES (PROTEIN CPN10) (PROTEIN FT GROES) (BCG-A HEAT SHOCK PROTEIN) (10 KDA ANTIGEN)" FT /note="Mb3452c, groES, len: 100 aa. Equivalent to Rv3418c, FT len: 100 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 100 aa overlap). groES (alternate gene FT names: cpn10, mpt57), 10 kDa chaperonin (protein cpn10) FT (see citations below), equivalent to FT P24301|CH10_MYCLE|MOPB|GROES|CHPA|ML0380|B1620_C3_227|B229_ FT C3_247 from Mycobacterium leprae (99 aa), FASTA scores: FT opt: 568, E(): 2.1e-31, (89.9% identity in 99 aa overlap). FT And also strongly identical to others e.g. FT O86017|CH10_MYCAV|MOPB|GROES from Mycobacterium avium and FT Mycobacterium paratuberculosis (99 aa), FASTA scores: opt: FT 611, E(): 2.9e-34, (96.95% identity in 99 aa overlap); FT P15020|CH10_MYCBO|MOPB|GROES from Mycobacterium bovis (99 FT aa), FASTA scores: opt: 596, E(): 2.9e-33, (98.95% identity FT in 94 aa overlap); P40172|CH10_STRCO|GROES|SC6G4.39 from FT Streptomyces coelicolor and Streptomyces lividans (102 aa), FT FASTA scores: opt: 480, E(): 1.6e-25, (76.75% identity in FT 99 aa overlap); etc. Also identical to MSG10KAG_1, FT MT10KAG_1, MTBCGA_1. Contains PS00681 Chaperonins cpn10 FT signature. BELONGS TO THE GROES CHAPERONIN FAMILY." FT /db_xref="GOA:P15020" FT /db_xref="HSSP:1P82" FT /db_xref="InterPro:IPR018369" FT /db_xref="UniProtKB/Swiss-Prot:P15020" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95639.1" FT /translation="MAKVNIKPLEDKILVQANEAETTTASGLVIPDTAKEKPQEGTVVA FT VGPGRWDEDGEKRIPLDVAEGDTVIYSKYGGTEIKYNGEEYLILSARDVLAVVSK" FT CDS complement(39183..40217) FT /transl_table=11 FT /gene="gcp" FT /locus_tag="Mb3453c" FT /product="PROBABLE O-SIALOGLYCOPROTEIN ENDOPEPTIDASE GCP FT (GLYCOPROTEASE)" FT /EC_number="3.4.24.57" FT /note="Mb3453c, -, len: 344 aa. Equivalent to Rv3419c, len: FT 344 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 344 aa overlap). Probable gcp, FT glycoprotease (EC 3.4.24.57), equivalent to FT P37969|GCP_MYCLE|GCP|ML0379|U229E|U1620c|B229_C3_246|B1620_ FT C3_226 PROBABLE GLYCOPROTEASE from Mycobacterium leprae FT (351 aa), FASTA scores: opt: 1898, E(): 2.4e-101, (86.1% FT identity in 345 aa overlap). Highly similar to others e.g. FT O86793|GCP_STRCO|GCP|SC6G4.30 from Streptomyces coelicolor FT (374 aa), FASTA scores: opt: 1282, E(): 4.1e-66, (60.45% FT identity in 344 aa overlap); Q9WXZ2|TM0145 from Thermotoga FT maritima (327 aa), FASTA scores: opt: 867, E(): 1.9e-42, FT (45.4% identity in 337 aa overlap); P05852|GCP_ECOLI|B3064 FT from Escherichia coli strain K12 (337 aa), FASTA scores: FT opt: 838, E(): 9e-41, (46.55% identity in 346 aa overlap); FT etc. Shows some similarity to FT Q50707|YY21_MYCTU|Rv3421c|MTCY78.08 (33.9% identity in 127 FT aa overlap). Contains PS01016 Glycoprotease family FT signature. BELONGS TO PEPTIDASE FAMILY M22; ALSO KNOWN AS FT THE GLYCOPROTEASE FAMILY." FT /db_xref="GOA:P65802" FT /db_xref="InterPro:IPR017861" FT /db_xref="UniProtKB/Swiss-Prot:P65802" FT /protein_id="CAD95640.1" FT /translation="MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFG FT GVVPEIASRAHLEALGPAMRRALAAAGLKQPDIVAATIGPGLAGALLVGVAAAKAYSAA FT WGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGSTVDD FT AAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTA FT VARYVESHAADPGFRTADIAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRL FT RELATQRCGEAGRTLRIPSPRLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDPGLPVMQ FT GQVR" FT CDS complement(40214..40690) FT /transl_table=11 FT /gene="rimI" FT /locus_tag="Mb3454c" FT /product="PROBABLE RIBOSOMAL-PROTEIN-ALANINE FT ACETYLTRANSFERASE RIMI (ACETYLATING ENZYME FOR N-TERMINAL FT OF RIBOSOMAL PROTEIN S18)" FT /EC_number="2.3.1.128" FT /note="Mb3454c, rimI, len: 158 aa. Equivalent to Rv3420c, FT len: 158 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 158 aa overlap). Probable rimI, FT ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), FT equivalent to C-terminal part of FT Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA FT PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: FT opt: 772, E(): 2.7e-44, (72.1% identity in 154 aa overlap). FT Similar notably to ribosomal-protein-alanine FT acetyltransferases e.g. Q9AC11|CC0058 from Caulobacter FT crescentus (150 aa), FASTA scores: opt: 223, E(): 4.9e-08, FT (37.5% identity in 136 aa overlap); Q9KFD4|BH0547 from FT Bacillus halodurans (151 aa), FASTA scores: opt: 222, E(): FT 5.8e-08, (35.2% identity in 142 aa overlap); Q9PG61|XF0441 FT from Xylella fastidiosa (156 aa), FASTA scores: opt: 207, FT E(): 5.9e-07, (32.2% identity in 149 aa overlap); FT Q9HVB7|RIMI|PA4678 from Pseudomonas aeruginosa (150 aa), FT FASTA scores: opt: 203, E(): 1.1e-06, (32.45% identity in FT 151 aa overlap); P09453|RIMI_ECOLI|B4373 from Escherichia FT coli strain K12 (148 aa), FASTA scores: opt: 196, E(): FT 3.1e-06, (33.55% identity in 149 aa overlap); etc. BELONGS FT TO THE ACETYLTRANSFERASE FAMILY, RIMI SUBFAMILY." FT /db_xref="GOA:Q7TWJ1" FT /db_xref="HSSP:1P0H" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q7TWJ1" FT /protein_id="CAD95641.1" FT /translation="MTADTEPVTIGALTRADAQRCAELEAQLFVGDDPWPPAAFNRELA FT SPHNHYVGARSGGTLVGYAGISRLGRTPPFEYEVHTIGVDPAYQGRGIGRRLLRELLDF FT ARGGVVYLEVRTDNDAALALYRSVGFQRVGLRRRYYRVSGADAYTMRRDSGDPS" FT CDS complement(40687..41322) FT /transl_table=11 FT /gene="Mb3455c" FT /locus_tag="Mb3455c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3455c, -, len: 211 aa. Equivalent to Rv3421c, len: FT 211 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 211 aa overlap). Conserved hypothetical FT protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 FT HYPOTHETICAL 38.0 KDA PROTEIN from Mycobacterium leprae FT (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% FT identity in 205 aa overlap). Also similar to other FT hypothetical bacterial proteins e.g. O86791|SC6G4.28 from FT Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, FT E(): 3.3e-19, (48.1% identity in 212 aa overlap); FT Q9AC10|CC0059 (GLYCOPROTEASE FAMILY PROTEIN) from FT Caulobacter crescentus (211 aa), FASTA scores: opt: 248, FT E(): 2e-07, (34.3% identity in 210 aa overlap); FT Q9KQK9|VC1989 from Vibrio cholerae (237 aa), FASTA scores: FT opt: 238, E(): 8.2e-07, (28.85% identity in 208 aa FT overlap); BAB51966|Mlr5530 from Rhizobium loti FT (Mesorhizobium loti) (225 aa), FASTA scores: opt: 237, E(): FT 9e-07, (35.0% identity in 220 aa overlap); etc. Some FT similarity to upstream FT Q50709|GCP_MYCTU|Rv3419c|MT3528|MTCY78.10 from M. FT tuberculosis (344 aa), (33.9% identity in 127 aa overlap)." FT /db_xref="GOA:P65084" FT /db_xref="InterPro:IPR000905" FT /db_xref="UniProtKB/Swiss-Prot:P65084" FT /protein_id="CAD95642.1" FT /translation="MSRVQISTVLAIDTATPAVTAGIVRRHDLVVLGERVTVDARAHAE FT RLTPNVLAALADAALTMADLDAVVVGCGPGPFTGLRAGMASAAAYGHALGIPVYGVCSL FT DAIGGQTIGDTLVVTDARRREVYWARYCDGIRTVGPAVNAAADVDPGPALAVAGAPEHA FT ALFALPCVEPSRPSPAGLVAAVNWADKPAPLVPLYLRRPDAKPLAVCT" FT CDS complement(41319..41825) FT /transl_table=11 FT /gene="Mb3456c" FT /locus_tag="Mb3456c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3456c, -, len: 168 aa. Equivalent to Rv3422c, len: FT 168 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 168 aa overlap). Conserved hypothetical FT protein, equivalent to FT Q49864|YY22_MYCLE|ML0377|U229F|B229_C2_205 HYPOTHETICAL FT 17.6 KDA PROTEIN from Mycobacterium leprae (161 aa), FASTA FT scores: opt: 752, E(): 8.3e-38, (77.4% identity in 146 aa FT overlap). Also similar to other hypothetical bacterial FT proteins e.g. O86788|YJEE_STRCO|SC6G4.25 from Streptomyces FT coelicolor (148 aa), FASTA scores: opt: 377, E(): 1.2e-15, FT (50.85% identity in 120 aa overlap); Q9X1W7|TM1632 from FT Thermotoga maritima (161 aa), FASTA scores: opt: 247, E(): FT 6.2e-08, (39.4% identity in 137 aa overlap); Q9RRY1|DR2351 FT from Deinococcus radiodurans (148 aa), FASTA scores: opt: FT 236, E(): 2.6e-07, (38.6% identity in 127 aa overlap); etc. FT Contains PS00017 ATP /GTP-binding site motif A." FT /db_xref="GOA:P67172" FT /db_xref="InterPro:IPR003442" FT /db_xref="UniProtKB/Swiss-Prot:P67172" FT /protein_id="CAD95643.1" FT /translation="MSREGIRRRPKARAGLTGGGTATLPRVEDTLTLGSRLGEQLCAGD FT VVVLSGPLGAGKTVLAKGIAMAMDVEGPITSPTFVLARMHRPRRPGTPAMVHVDVYRLL FT DHNSADLLSELDSLDLDTDLEDAVVVVEWGEGLAERLSQRHLDVRLERVSHSDTRIATW FT SWGRS" FT CDS complement(41822..43048) FT /transl_table=11 FT /gene="alr" FT /locus_tag="Mb3457c" FT /product="PROBABLE ALANINE RACEMASE ALR" FT /EC_number="5.1.1.1" FT /note="Mb3457c, alr, len: 408 aa. Equivalent to Rv3423c, FT len: 408 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 408 aa overlap). Probable alr, alanine FT racemase (EC 5.1.1.1), equivalent to FT P38056|ALR_MYCLE|ML0375|B229_C3_243 ALANINE RACEMASE from FT Mycobacterium leprae (388 aa), FASTA scores: opt: 2160, FT E(): 2.3e-124, (84.35% identity in 384 aa overlap). Also FT highly similar to other alanine racemases e.g. FT Q9L888|ALR_MYCAV from Mycobacterium avium (391 aa), FASTA FT scores: opt: 2103, E(): 6.8e-121, (83.6% identity in 384 aa FT overlap); P94967|ALR_MYCSM from M. smegmatis (389 aa), FT FASTA scores: opt: 1721, E(): 1.3e-97, (67.25% identity in FT 385 aa overlap); O86786|ALR_STRCO|SC6G4.23 from FT Streptomyces coelicolor (391 aa), FASTA scores: opt: 1041, FT E(): 3.7e-56, (47.65% identity in 380 aa overlap); etc. FT BELONGS TO THE ALANINE RACEMASE FAMILY." FT /db_xref="GOA:P0A4X3" FT /db_xref="HSSP:1BD0" FT /db_xref="InterPro:IPR000821" FT /db_xref="UniProtKB/Swiss-Prot:P0A4X3" FT /protein_id="CAD95644.1" FT /translation="MKRFWENVGKPNDTTDGRGTTSLAMTPISQTPGLLAEAMVDLGAI FT EHNVRVLREHAGHAQLMAVVKADGYGHGATRVAQTALGAGAAELGVATVDEALALRADG FT ITAPVLAWLHPPGIDFGPALLADVQVAVSSLRQLDELLHAVRRTGRTATVTVKVDTGLN FT RNGVGPAQFPAMLTALRQAMAEDAVRLRGLMSHMVYADKPDDSINDVQAQRFTAFLAQA FT REQGVRFEVAHLSNSSATMARPDLTFDLVRPGIAVYGLSPVPALGDMGLVPAMTVKCAV FT ALVKSIRAGEGVSYGHTWIAPRDTNLALLPIGYADGVFRSLGGRLEVLINGRRCPGVGR FT ICMDQFMVDLGPGPLDVAEGDEAILFGPGIRGEPTAQDWADLVGTIHYEVVTSPRGRIT FT RTYREAENR" FT CDS complement(43342..43704) FT /transl_table=11 FT /gene="Mb3458c" FT /locus_tag="Mb3458c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3458c, -, len: 120 aa. Equivalent to Rv3424c, len: FT 120 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 120 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/Swiss-Prot:P65086" FT /protein_id="CAD95645.1" FT /translation="MPNPVTMLYGRKADLVILPHVLAEERPHPYSTPGRKRGAQIALTT FT GIDALASFAPQIVNPRHGLSRVVQCLGGCENKRHAYFRSISKTPHIRARGVPSVCAVRT FT VGVDGAKRPPKPIPVQ" FT CDS 43867..44403 FT /transl_table=11 FT /gene="PPE57" FT /locus_tag="Mb3459" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3459, PPE57, len: 178 aa. Equivalent to 5' end of FT Rv3425, len: 176 aa, from Mycobacterium tuberculosis strain FT H37Rv, (90.9% identity in 176 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family, similar to many e.g. FT O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt: 781, FT E(): 7e-44, (69.9% identity in 176 aa overlap); and FT downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FT FASTA scores: opt: 517, E(): 1.2e-26, (68.0% identity in FT 125 aa overlap); MTV049_11, MTCY428_16, MTV049_22, FT MTV049_30, MTCY261_4; etc. Rv3429: Member of the M. FT tuberculosis PPE family, similar to many e.g. the upstream FT Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FASTA scores: FT opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); FT and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA FT scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa FT overlap) (but diverges at 3' end)); etc. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT large deletion of 4926 bp (RD6) leads to the loss of the FT COOH part of PPE57, and the following CDSs, PPE58, Rv3427c, FT Rv3428c and PPE59 compared to Mycobacterium tuberculosis FT strain H37Rv." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TWJ0" FT /protein_id="CAD95646.1" FT /translation="MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESLE FT DELDELDENWKGSSSDLLADAVERYLQWLSKHSSQLKHAAWVINGLANAYNDTRRKVVP FT PEEIAANREEVHRLIASNVAGVNTPAIAGLDAQYQQYRAQNIAVMNDYQSTARFILAYL FT PRWQEPPQIYGGGGG" FT CDS complement(44344..45507) FT /transl_table=11 FT /gene="Mb3460c" FT /locus_tag="Mb3460c" FT /product="POSSIBLE TRANSPOSASE" FT /note="Mb3460c, -, len: 387 aa. Equivalent to Rv3430c, len: FT 387 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 387 aa overlap). Possible IS1540 FT transposase, similar to several e.g. Q49592 transposase FT from Mycobacterium intracellulare (340 aa), FASTA scores: FT opt: 1377, E(): 1.6e-81, (64.2% identity in 338 aa FT overlap); similarity is lost at C-terminus due to possible FT frameshift after aa 297." FT /db_xref="GOA:Q7TWI9" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/TrEMBL:Q7TWI9" FT /protein_id="CAD95647.1" FT /translation="MIDTAIEEMIPLIGVRAACAATGRAPASYYRAHSKRLSAQSDTFT FT STAVTDPSGPRESAQPRALSAAEREHVLAVLNSQRFADMAPAVVYATLLDEGIYLCSES FT TMYRLLRERGQTGDRRRQATHPAAVKPELVAHQPNSVWSWDITKLRGPAKWSYYYLYVI FT LDIFSRYVVGWMVASRESKVLAERLIAQTLAAQHISADQLTLHADRGSSMSSKPVALLL FT ADLGVTKSHSHPHTSNDNPLSEAQFKTLKYRPDFPKRFESIEAARVHCDRFFGWYNHEH FT KHSGIGLHTPADVHYGRADQIRRHRATVLDTAYRDHLERIRSQTTRATRATGLQRDQPT FT TEGGPADSINPRKSCLRNVDRFRPGLLDLPAPAPVDLRRLLPSGQIR" FT repeat_region complement(44344..45507) FT /mobile_element="insertion sequence:IS1540" FT /locus_tag="IS1540-2" FT /note="IS1540-2, len: 1163 nt. Equivalent to IS1540, len: FT 1163 nt, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1163 nt overlap)." FT CDS complement(45996..46841) FT /transl_table=11 FT /gene="Mb3461c" FT /locus_tag="Mb3461c" FT /product="POSSIBLE TRANSPOSASE" FT /note="Mb3461c, -, len: 281 aa. Equivalent to Rv3431c, len: FT 281 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 281 aa overlap). Possible truncated FT transposase for IS1552, similar to, but shorter than other FT transposases e.g. P72303 from Rhodococcus opacus (418 aa), FT FASTA scores: opt: 1509, E(): 1.2e-91, (80.95% identity in FT 278 aa overlap); Q9AKV5 from Mycobacterium paratuberculosis FT (395 aa), FASTA scores: opt: 1115, E(): 7.8e-66, (63.45% FT identity in 268 aa overlap); etc." FT /db_xref="GOA:Q7TWI8" FT /db_xref="InterPro:IPR001207" FT /db_xref="UniProtKB/TrEMBL:Q7TWI8" FT /protein_id="CAD95648.1" FT /translation="MFAELIRAGLQALIEAEATEAIGAGRYERSDGRIVHRNGHRPKTV FT STTAGDIEVQIPKLRAGSFFPSLLERRRRIDKALHAVIMEAYVHGVSTRSVDDLVAAMG FT VQAGVSKSEVSRICAGLDTEIEAFRTRSLTHTEFPYVFCDATFCKVRVGAHVVSQALVV FT ATGVSIDGTREVLGTAVGDSESYEFWREFLASLKARGLTGVHLVISDAHAGLKAAVAQQ FT FSGASWQRCRVHFMRNLYTAVAAKHAPAVTVAVKTIFAHTDPEEVGAQWDRVADPLCQP FT " FT repeat_region complement(45998..46842) FT /mobile_element="insertion sequence:IS1552" FT /locus_tag="IS1552" FT /note="IS1552, len: 845 nt. Equivalent to IS1552, len: 845 FT nt, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 845 nt overlap)." FT CDS complement(47074..48456) FT /transl_table=11 FT /gene="gadB" FT /locus_tag="Mb3462c" FT /product="PROBABLE GLUTAMATE DECARBOXYLASE GADB" FT /EC_number="4.1.1.15" FT /note="Mb3462c, gadB, len: 460 aa. Equivalent to Rv3432c, FT len: 460 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 460 aa overlap). Probable gadB, FT glutamate decarboxylase (EC 4.1.1.15), similar to many e.g. FT P73043|GAD|SLL1641 from Synechocystis sp. strain PCC 6803 FT (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% FT identity in 457 aa overlap); Q9X8J5|SCE9.23 from FT Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650, FT E(): 8.9e-97, (57.4% identity in 446 aa overlap); FT Q9AQU4|GAD from Oryza sativa (Rice) (501 aa), FASTA scores: FT opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa FT overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) FT (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15% FT identity in 437 aa overlap); etc. BELONGS TO GROUP II FT DECARBOXYLASES (DDC, GAD, HDC AND TYRDC)." FT /db_xref="GOA:Q7TWI7" FT /db_xref="HSSP:1PMM" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/TrEMBL:Q7TWI7" FT /protein_id="CAD95649.1" FT /translation="MSRSHPSVPAHSIAPAYTGRMFTAPVPALRMPDESMDPEAAYRFI FT HDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPATAAIEARCVSMVA FT DLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKWRWRQRVGSWKGRMPNLVMGSNV FT QVVWEKFCRYFDVEPRYLPMERGRYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIA FT EICAALDKLAAGGGVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLT FT YPGVGFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRLGRDGY FT TKVMQALSHTARWLGDQLREVDHCEVISDGSAIPVVSFRLAGDRGYTEFDVSHELRTFG FT WQVPAYTMPDNATDVAVLRIVVREGLSADLARALHDDAVTALAALDKVKPGGHFDAQHF FT AH" FT CDS complement(48494..49915) FT /transl_table=11 FT /gene="Mb3463c" FT /locus_tag="Mb3463c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3463c, -, len: 473 aa. Equivalent to Rv3433c, len: FT 473 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 473 aa overlap). Hypothetical protein, FT member of YKL151c/yjeF family, equivalent to FT P37391|YY33_MYCLE|ML0373|U229G|B229_C2_201 HYPOTHETICAL FT 47.2 KDA PROTEIN from Mycobacterium leprae (473 aa), FASTA FT scores: opt: 2650, E(): 5e-136, (84.55% identity in 473 aa FT overlap). Also similar to other hypothetical bacterial FT proteins e.g. Q9X3W3 from Zymomonas mobilis (484 aa), FASTA FT scores: opt: 700, E(): 1.2e-30, (33.7% identity in 484 aa FT overlap); O86783|SC6G4.20c from Streptomyces coelicolor FT (485 aa), FASTA scores: opt: 563, E(): 3.2e-23, (48.45% FT identity in 489 aa overlap); Q9LC81 from Arthrobacter sp. FT Q36 (313 aa), FASTA scores: opt: 553, E(): 7.9e-23, (44.2% FT identity in 303 aa overlap); etc. Contains PS01049 FT Hypothetical YKL151c/yjeF family signature 1, PS01050 FT Hypothetical YKL151c/yjeF family signature 2." FT /db_xref="HSSP:1ESQ" FT /db_xref="InterPro:IPR004443" FT /db_xref="UniProtKB/TrEMBL:Q7TWI6" FT /protein_id="CAD95650.1" FT /translation="MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTAR FT TGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGG FT RLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGA FT ITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPG FT PRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIAS FT PTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRN FT APTVLTPHAGEFARLAGAPPGDDRVGACRQLADALGATVLLKGNVTVIADPGGPVYLNP FT AGQSWAATAGSGDVLSGMIGALLASGLPSGEAAAAAAFVHARAAAAAAADPGPGDAPTS FT ASRISGHIRAALAAL" FT CDS complement(49917..50630) FT /transl_table=11 FT /gene="Mb3464c" FT /locus_tag="Mb3464c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb3464c, -, len: 237 aa. Equivalent to Rv3434c, len: FT 237 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 237 aa overlap). Possible conserved FT transmembrane protein, showing some similarity with FT Q9CGH7|YLDB HYPOTHETICAL PROTEIN from Lactococcus lactis FT (subsp. lactis) (Streptococcus lactis) (258 aa), FASTA FT scores: opt: 248, E(): 1.6e-09, (28.8% identity in 198 aa FT overlap); and P94983|Rv1648|MTCY06H11.13 from Mycobacterium FT tuberculosis (268 aa), FASTA scores: opt: 205, E(): FT 1.2e-06, (31.45% identity in 194 aa overlap)." FT /db_xref="GOA:Q7TWI5" FT /db_xref="UniProtKB/TrEMBL:Q7TWI5" FT /protein_id="CAD95651.1" FT /translation="MADASVVARLRSWALAVWHFVSNAPLTYAWLVVLVITTIIQNNLT FT GSQLHFVLLHRSTNIAELGRDPLEVLFSSLLWIDGRNLEPYLLLFTLFLAPAEHWLGHL FT RWLTVGLTAHIGATYLSEGLLYLAIQHRDASERMVHARDIGVSYFLVGVMAVLTYHIAK FT PWRWGYLGVLLVIFGFPLIAMDKAELDFTTVGHFASILIGLLFYPMARERDGRLWNPAR FT IKSLLHRRGTRGRRA" FT CDS complement(50641..51495) FT /transl_table=11 FT /gene="Mb3465c" FT /locus_tag="Mb3465c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb3465c, -, len: 284 aa. Equivalent to Rv3435c, len: FT 284 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 284 aa overlap). Probable conserved FT transmembrane protein, showing some similarity with FT P95061|Rv0713|MTCY210.32 HYPOTHETICAL 33.9 KDA PROTEIN from FT Mycobacterium tuberculosis (313 aa), FASTA scores: opt: FT 557, E(): 1.3e-26, (35.8% identity in 282 aa overlap); and FT O32991|MLCB2492.12 from Mycobacterium leprae (95 aa), FASTA FT scores: opt: 150, E(): 0.022, (35.3% identity in 85 aa FT overlap). Equivalent to AAK47881 from Mycobacterium FT tuberculosis strain CDC1551 (312 aa) but shorter 28 aa." FT /db_xref="GOA:Q7TWI4" FT /db_xref="UniProtKB/TrEMBL:Q7TWI4" FT /protein_id="CAD95652.1" FT /translation="MGRILRVVVGLVLVIAAYVTVIALYHSTGLGRPHEVAHGRPTADG FT TTVTLHVEQLQTIKGVLVANLAVSPGTELLDSQTQGLKDDLTVTVTSVVTPTKRTWSSG FT SLPGVFPVPLTISGDPANWPFDHYRSGPITVQLYRGAAHAPERVSVTFVDRLPGWNVDI FT SGVGDANVPAPYRVGLHRSPSSVAFGTVIVGVLIALAGVGLFVAVQTARGRRQFQPPMT FT TWYAAMLFAVIPLRNALPDAPPIGFWIDVTVVLWVVVALVTSMVLYILCWWWHLKPDVD FT ETM" FT CDS complement(51717..53591) FT /transl_table=11 FT /gene="glmS" FT /locus_tag="Mb3466c" FT /product="PROBABLE GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE FT AMINOTRANSFERASE [ISOMERIZING] GLMS (HEXOSEPHOSPHATE FT AMINOTRANSFERASE) (D-FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE) FT (GFAT) (L-GLUTAMINE-D-FRUCTOSE-6-PHOSPHATE FT AMIDOTRANSFERASE) (GLUCOSAMINE-6-PHOSPHATE SYNTHASE)" FT /EC_number="2.6.1.16" FT /note="Mb3466c, glmS, len: 624 aa. Equivalent to Rv3436c, FT len: 624 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 624 aa overlap). Probable glmS, FT glucosamine--fructose-6-phosphate aminotransferase (EC FT 2.6.1.16), equivalent to FT P40831|GLMS_MYCLE|ML0371|B229_C3_238 FT GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE FT [ISOMERIZING] from Mycobacterium leprae (623 aa), FASTA FT scores: opt: 3584, E(): 4.7e-214, (89.3% identity in 627 aa FT overlap). Also highly similar to others e.g. FT O68956|GLMS_MYCSM from Mycobacterium smegmatis (627 aa), FT FASTA scores: opt: 3517, E(): 6.5e-210, (87.25% identity in FT 627 aa overlap); O86781|GLMS_STRCO|SC6G4.18 from FT Streptomyces coelicolor (614 aa), FASTA scores: opt: 2364, FT E(): 1.3e-138, (64.95% identity in 625 aa overlap); FT Q9K1P9|NMB0031 from Neisseria meningitidis (serogroup B) FT and Q9JWN9|GLMS|NMA0276 from Neisseria meningitidis FT (serogroup A) (612 aa), FASTA scores: opt: 1445, E(): FT 8.4e-82, (43.55% identity in 627 aa overlap); etc. BELONGS FT TO THE TYPE-2 GATASE DOMAIN IN THE N-TERMINAL SECTION. FT BELONGS TO THE SIS FAMILY, GLMS SUBFAMILY, IN THE FT C-TERMINAL SECTION." FT /db_xref="GOA:P0A589" FT /db_xref="HSSP:1MOS" FT /db_xref="InterPro:IPR001347" FT /db_xref="UniProtKB/Swiss-Prot:P0A589" FT /protein_id="CAD95653.1" FT /translation="MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVR FT RRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNG FT IIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRLEGH FT FTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVI FT TADGYRISDFDGNDGLQAGRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLL FT GHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELAS FT EFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAV FT LYTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVAR FT VIAATGPVAELAHRFAQSSTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHG FT PIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTIVIAEEGDETVRPYADH FT LIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE" FT CDS 53613..54089 FT /transl_table=11 FT /gene="Mb3467" FT /locus_tag="Mb3467" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb3467, -, len: 158 aa. Equivalent to Rv3437, len: FT 158 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 158 aa overlap). Possible conserved FT transmenbrane protein, C-terminus similar to N-terminal FT part of O06345|Rv3482c|MTCY13E12.35c HYPOTHETICAL 28.5 KDA FT PROTEIN from Mycobacterium tuberculosis (260 aa), FASTA FT scores: opt: 140, E(): 0.1, (58.8% identity in 34 aa FT overlap); and Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN FT from Streptomyces (347 aa), coelicolor FASTA scores: opt: FT 112, E(): 6.8, (50.0% identity in 32 aa overlap). FT Questionable ORF." FT /db_xref="GOA:Q7TWI3" FT /db_xref="InterPro:IPR018929" FT /db_xref="UniProtKB/TrEMBL:Q7TWI3" FT /protein_id="CAD95654.1" FT /translation="MVGRAVPSPNRRYRRVWPPRTKGQHLSNPYAQHQLKLIRHTGALI FT LWQQRTYVVSGTREQCEAAYKSAQTYNLLVGWWSLVSLPAMNWIALISNFNAIRRVRAA FT ADGASVPHGPHAIAHPAVPRGPIPAGWYPDPSGAGLRYWDGATWTHWTHPPRHR" FT CDS 54099..54941 FT /transl_table=11 FT /gene="Mb3468" FT /locus_tag="Mb3468" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3468, -, len: 280 aa. Equivalent to Rv3438, len: FT 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 280 aa overlap). Conserved hypothetical FT protein, equivalent to Q9CCV6|ML0370 HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (289 aa), FASTA scores: opt: FT 1491, E(): 9.2e-81, (79.85% identity in 283 aa overlap); FT and highly similar (but shorter 41 aa) to Q49872|B229_F1_20 FT HYPOTHETICAL 34.0 KDA PROTEIN from Mycobacterium leprae FT (324 aa), FASTA scores: opt: 1491, E(): 1e-80, (79.85% FT identity in 283 aa overlap). Shows some similarity to FT Q9KIU3|LIPA LIPASE from plasmid pAH114 uncultured bacterium FT (281 aa), FASTA scores: opt: 168, E(): 0.0081, (29.3% FT identity in 140 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWI2" FT /protein_id="CAD95655.1" FT /translation="MPRIRKLVAALHRRGPHRVLRGDLAFAGLPGVVYTPEAGLHLPGV FT AFGHDWLTGTSRYSGLLEHLASWGIVAAAPDSERGLAPSVLNLAFDLGVALDIVAGVRL FT GPGKISVHPAKLGLVGHGFGGSAAVFAAAGLTGTHVKSVAAIFPTVTNPAAEQPAATLD FT VPGLILTAPGDPKTLTSNALGLSRAWDKATLRIVSKARAGGLVEGRRLTKVLGLPGPHR FT RTQRSVRALLTGYLLYTLGGDKTYRRFADPDLQLPKTDPIDPEAPPITPGEKIVTLLK" FT CDS complement(54961..56364) FT /transl_table=11 FT /gene="Mb3469c" FT /locus_tag="Mb3469c" FT /product="CONSERVED HYPOTHETICAL ALANINE AND PROLINE RICH FT PROTEIN" FT /note="Mb3469c, -, len: 467 aa. Equivalent to Rv3439c, len: FT 467 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 467 aa overlap). Conserved hypothetical FT ala-, pro-rich protein, similar in part to N-terminal part FT of Q49853|B229_C1_154 HYPOTHETICAL 11.2 KDA PROTEIN from FT Mycobacterium leprae (103 aa), FASTA scores: opt: 265, E(): FT 0.0013, (51.1% identity in 90 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWI1" FT /protein_id="CAD95656.1" FT /translation="MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPAQI FT HDWYGSEDGLDLHALDADCAQLRAAASVLMEALRMERSQVAVLAAAWTGSGADAAVHFV FT QRHCETGNSVVTEVRAAAQRCESLRDNLWQLVDSKVATAIAIDERALAQRPAWLAAAEA FT LTTEGADRPTAVEVVRQQIQPYVDDDVRNDWLTTMRSTTAGVAASYDAVTDQLASAPRA FT HFEIPDDLGPGRQPSPASVPAQPSATAAITPAAALPPPDPVPAVTSRPVTPSDFGSAPG FT DGSATPAGVGSAGGFGDAGGTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLGDPLAAD FT NPPGAVDPFAEDAADNADDGDDAHPEEADEAAEPKEATEPDEADEVDDADESVPAERAQ FT DVAEEATLPPVAEPPPPAAPPVAEPPPPVAAPAPPGAPEPANGPSPEALSEGATPCEIA FT ADELPQAGP" FT CDS complement(56367..56678) FT /transl_table=11 FT /gene="Mb3470c" FT /locus_tag="Mb3470c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3470c, -, len: 103 aa. Equivalent to Rv3440c, len: FT 103 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 103 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TWI0" FT /protein_id="CAD95657.1" FT /translation="MRPDSVNSAGIDIAAVYAVADRFSAAAELIDDAIGNHLTRLAFGG FT ACAGRGHASRGDALRCRLDRLAGELSVWSRAAVQIAFALRAGANRYAEADLCAAARIG" FT CDS complement(56726..58072) FT /transl_table=11 FT /gene="mrsA" FT /locus_tag="Mb3471c" FT /product="PROBABLE PHOSPHO-SUGAR MUTASE / MRSA PROTEIN FT HOMOLOG" FT /EC_number="5.4.2.-" FT /note="Mb3471c, mrsA, len: 448 aa. Equivalent to Rv3441c, FT len: 448 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 448 aa overlap). Probable mrsA, FT phosphoglucomutase or phosphomannomutase (EC 5.4.2.-), FT equivalent to Q49869|URED|B229_C3_234 MRSA PROTEIN HOMOLOG FT from Mycobacterium leprae (463 aa), FASTA scores: opt: FT 2449, E(): 6.3e-135, (87.65% identity in 445 aa overlap); FT and highly similar (but longer 178 aa) to FT Q49862|UREC|B229_C2_192 PUTATIVE UREASE OPERON UREC PROTEIN FT from Mycobacterium leprae (288 aa), FASTA scores: opt: FT 1442, E(): 1.3e-76, (86.5% identity in 267 aa overlap). FT Highly similar to phospho-sugar mutases e.g. FT Q53876|SC6G4.14 PUTATIVE PHOSPHO-SUGAR MUTASE (SIMILAR TO FT PHOSPHOMANNOMUTASES) from Streptomyces coelicolor (452 aa), FT FASTA scores: opt: 1710, E(): 5e-92, (60.45% identity in FT 450 aa overlap); Q9KG46|BH0267 PHOSPHOGLUCOSAMINE MUTASE FT from Bacillus halodurans (447 aa), FASTA scores: opt: 1351, FT E(): 3.5e-71, (48.4% identity in 444 aa overlap); FT BAB58323|GLMM PHOSPHOGLUCOSAMINE-MUTASE from Staphylococcus FT aureus subsp. aureus Mu50 (451 aa) and FT Q99QR5|GLMM(FEMD)|SA1965 PHOSPHOGLUCOSAMINE-MUTASE from FT Staphylococcus aureus subsp. aureus N315. (451 aa), FASTA FT scores: opt: 1315, E(): 4.3e-69, (48.45% identity in 446 aa FT overlap); P95685|FEMD|GLMM PHOSPHOGLUCOSAMINE-MUTASE (451 FT aa), FASTA scores: opt: 1310, E(): 8.5e-69, (48.2% identity FT in 446 aa overlap); P95575|MRSA_PSESY MRSA PROTEIN HOMOLOG FT from Pseudomonas syringae (pv. syringae) (447 aa), FASTA FT scores: opt: 1143, E(): 4.2e-59, (42.75% identity in 447 aa FT overlap); etc. Contains PS00710 Phosphoglucomutase and FT phosphomannomutase phosphoserine signature. BELONGS TO THE FT PHOSPHOHEXOSE MUTASES FAMILY." FT /db_xref="GOA:Q7TWH9" FT /db_xref="InterPro:IPR006352" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWH9" FT /protein_id="CAD95658.1" FT /translation="MGRLFGTDGVRGVANRELTAELALALGAAAARRLSRSGAPGRRVA FT VLGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTGAYDADFGVMISASHN FT PMPDNGIKIFGPGGHKLDDDTEDQIEDLVLGVSRGPGLRPAGAGIGRVIDAEDATERYL FT RHVAKAATARLDDLAVVVDCAHGAASSAAPRAYRAAGARVIAINAEPNGRNINDGCGST FT HLDPLRAAVLAHRADLGLAHDGDADRCLAVDANGDLVDGDAIMVVLALAMKEAGELACN FT TLVATVMSNLGLHLAMRSAGVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIVMPALGS FT TGDGIVTGLRLMTRMVQTGSSLSDLASAMRTLPQVLINVEVVDKATAAAAPSVRTAVEQ FT AAAELGDTGRILLRPSGTEPMIRVMVEAADEGVAQRLAATVADAVSTAR" FT CDS complement(58197..58652) FT /transl_table=11 FT /gene="rpsI" FT /locus_tag="Mb3472c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S9 RPSI" FT /note="Mb3472c, rpsI, len: 151 aa. Equivalent to Rv3442c, FT len: 151 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 151 aa overlap). Probable rpsI, FT ribosomal protein S9, equivalent to FT P40828|RS9_MYCLE|ML0365|B229_C2_191 30S RIBOSOMAL PROTEIN FT S9 (153 aa), FASTA scores: opt: 800, E(): 2.1e-42, (83.85% FT identity in 155 aa overlap). Also highly similar to others FT e.g. Q53875|RS9_STRCO|SC6G4.13 from Streptomyces coelicolor FT (170 aa), FASTA scores: opt: 533, E(): 5.7e-26, (60.75% FT identity in 135 aa overlap); Q9KGD4|RPSI|BH0169 (BS10) from FT Bacillus halodurans (130 aa), FASTA scores: opt: 469, E(): FT 3.8e-22, (58.65% identity in 121 aa overlap); Q9CDG7|RPSI FT from Lactococcus lactis (subsp. lactis) (Streptococcus FT lactis) (130 aa), FASTA scores: opt: 451, E(): 4.9e-21, FT (58.65% identity in 121 aa overlap); P07842|RS9_BACST|RPSI FT from Bacillus stearothermophilus (129 aa), FASTA scores: FT opt: 448, E(): 7.4e-21, (54.55% identity in 121 aa FT overlap); etc. Contains PS00360 Ribosomal protein S9 FT signature. BELONGS TO THE S9P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P66640" FT /db_xref="HSSP:1J5E" FT /db_xref="InterPro:IPR000754" FT /db_xref="UniProtKB/Swiss-Prot:P66640" FT /protein_id="CAD95659.1" FT /translation="MTETTPAPQTPAAPAGPAQSFVLERPIQTVGRRKEAVVRVRLVPG FT TGKFDLNGRSLEDYFPNKVHQQLIKAPLVTVDRVESFDIFAHLGGGGPSGQAGALRLGI FT ARALILVSPEDRPALKKAGFLTRDPRATERKKYGLKKARKAPQYSKR" FT CDS complement(58649..59092) FT /transl_table=11 FT /gene="rplM" FT /locus_tag="Mb3473c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L13 RPLM" FT /note="Mb3473c, rplM, len: 147 aa. Equivalent to Rv3443c, FT len: 147 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 147 aa overlap). Probable rplM, 50S FT ribosomal protein L13, equivalent to FT P38014|RL13_MYCLE|RPLM|ML0364|B229_C3_232 from FT Mycobacterium leprae (147 aa), FASTA scores: opt: 917, E(): FT 7.5e-53, (91.15% identity in 147 aa overlap). Also highly FT similar to others e.g. Q53874|RL13_STRCO|RPLM|SC6G4.12 from FT Streptomyces coelicolor (147 aa), FASTA scores: opt: 668, FT E(): 1.1e-36, (65.5% identity in 145 aa overlap); FT Q9X1G5|RL13_THEMA|RPLM|TM1454 from Thermotoga maritima (149 FT aa), FASTA scores: opt: 536, E(): 4.4e-28, (53.65% identity FT in 136 aa overlap); O67722|RL13_AQUAE|RPLM|AQ_1877 from FT Aquifex aeolicus (144 aa), FASTA scores: opt: 529, E(): FT 1.2e-27, (53.2% identity in 141 aa overlap); etc. BELONGS FT TO THE L13P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66066" FT /db_xref="InterPro:IPR005823" FT /db_xref="UniProtKB/Swiss-Prot:P66066" FT /protein_id="CAD95660.1" FT /translation="MPTYAPKAGDTTRSWYVIDATDVVLGRLAVAAANLLRGKHKPTFA FT PNVDGGDFVIVINADKVAISGDKLQHKMVYRHSGYPGGLHKRTIGELMQRHPDRVVEKA FT ILGMLPKNRLSRQIQRKLRVYAGPEHPHSAQQPVPYELKQVAQ" FT CDS complement(59325..59627) FT /transl_table=11 FT /gene="esxT" FT /locus_tag="Mb3474c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3474c, esxT, len: 100 aa. Equivalent to Rv3444c, FT len: 100 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 100 aa overlap). esxT, conserved FT hypothetical protein, equivalent to Q9CCV7|ML0363 POSSIBLE FT SECRETED PROTEIN from Mycobacterium leprae (104 aa), FASTA FT scores: opt: 362, E(): 1.1e-18, (71.25% identity in 73 aa FT overlap). C-terminal part highly similar to FT Q49852|B229_C1_150 HYPOTHETICAL 5.3 KDA PROTEIN from FT Mycobacterium leprae (49 aa), FASTA scores: opt: 227, E(): FT 1.4e-09, (68.9% identity in 45 aa overlap)." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/TrEMBL:Q7TWH8" FT /protein_id="CAD95661.1" FT /translation="MNADPVLSYNFDAIEYSVRQEIHTTAARFNAALQELRSQIAPLQQ FT LWTREAAAAYHAEQLKWHQAASALNEILIDLGNAVRHGADDVAHADRRAAGAWAR" FT CDS complement(59648..60025) FT /transl_table=11 FT /gene="esxU" FT /locus_tag="Mb3475c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3475c, esxU, len: 125 aa. Equivalent to Rv3445c, FT len: 125 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 125 aa overlap). esxU, hypothetical FT unknown protein, showing weak similarity to FT O30373|VCD|PA2257 PYOVERDINE BIOSYNTHESIS PROTEIN from FT Pseudomonas aeruginosa (215 aa), FASTA scores: opt: 103, FT E(): 5.6, (32.35% identity in 133 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWH7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95662.1" FT /translation="MVEPGRIGGNQTRLAAVLLDVSTPNTLNADFDLMRSVAGITDARN FT EEIRAMLQAFIGRMSGVPPSVWGGLAAARFQDVVDRWNAESTRLYHVLHAIADTIRHNE FT AALREAGQIHARHIAAAGGDL" FT CDS complement(60018..61232) FT /transl_table=11 FT /gene="Mb3476c" FT /locus_tag="Mb3476c" FT /product="HYPOTHETICAL ALANINE AND VALINE RICH PROTEIN" FT /note="Mb3476c, -, len: 404 aa. Equivalent to Rv3446c, len: FT 404 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 404 aa overlap). Hypothetical unknown FT ala-, val-rich protein." FT /db_xref="UniProtKB/TrEMBL:Q7TWH6" FT /protein_id="CAD95663.1" FT /translation="MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALL FT DERPVAVDSLWFDALRSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRS FT WLLRQASSGVSAATVVVEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGIT FT AVVLIDVPSTVAGAAALAAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAA FT RPATRSRVPTLARVAAAGVALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWS FT TQRVVSGPGSARVQVTSPADPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDF FT NPSDIRAGRPAVTYREVRAGHQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRS FT VHAVG" FT CDS complement(61229..64939) FT /transl_table=11 FT /gene="Mb3477c" FT /locus_tag="Mb3477c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb3477c, -, len: 1236 aa. Equivalent to Rv3447c, FT len: 1236 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 1236 aa overlap). Probable conserved FT membrane protein, similar to various bacterial proteins FT e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from FT Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, FT E(): 1.9e-60, (42.9% identity in 1312 aa overlap); FT Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa), FT FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in FT 1374 aa overlap); Q9CD30|ML2535 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (1329 aa), FASTA scores: opt: 910, FT E(): 1.5e-44, (34.4% identity in 1319 aa overlap); FT Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans FT (1489 aa), FASTA scores: opt: 805, E(): 1.9e-38, (25.85% FT identity in 1292 aa overlap); etc. The C-terminal region is FT similar to Q9CDD7|ML0052 (alias O33086|MLCB628.15c) FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FT FASTA scores: opt: 850, E(): 2.3e-41, (35.2% identity in FT 588 aa overlap); and O6973|Rv3871|MTV027.06 HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (591 aa), FASTA FT scores: opt: 845, E(): 4.3e-41, (35.3% identity in 586 aa FT overlap). N-terminal part shows similarity with FT HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. FT O69735|Rv3870|MTV027.05 (747 aa), FASTA scores: opt: 761, FT E(): 3.6e-36, (38.2% identity in 746 aa overlap). FT Equivalent to AAK47893 from Mycobacterium tuberculosis FT strain CDC1551 (1200 aa) but longer 36 aa. Contains three FT of PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7TWH5" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TWH5" FT /protein_id="CAD95664.1" FT /translation="MNSGPACATADILVAPPPELRRSEPSSLLIRLLPVVMSVATVGVM FT VTVFLPGSPATRHPTFLAFPMMMLVSLVVTAVTGRGRRHVSGIHNDRVDYLGYLSVLRT FT SVTQTAAAQHVSLNWTHPDPATLWTLIGGPRMWERRPGAADFCRIRVGVGSAPLATRLV FT VGQLPPAQRADPVTRAALRCFLAAHATIADAPIAIPLRVGGPIAIDGDPTKVRGLLRAM FT ICQLAVWHSPEELLIAGVVSDRNRAHWDWLKWLPHNQHPNACDALGPAPMVYSTLAEMQ FT NALAATVLAHVVAIVDTAERGNGAITGVITIEVGARRDGAPPVVRCAGEVTALACPDQL FT EPQDALVCARRLAAHRVGHSGRTFIRGSGWAELVGIGDVAAFDPSTLWRNVNQHDRLRV FT PIGVTPDGTAVQLDIKEAAEQGMGPHGLCVGATGSGKSELLRTIALGMMARNSPEVLNL FT LLVDFKGGATFLDLAGAPHVAAVITNLAEEAPLVARMQDALAGEMSRRQQLLRMAGHLV FT SVTAYQRARQTGAQLPCLPILFIVVDEFSELLSQHPEFVDVFLAIGRVGRSLGMHLLLA FT SQRLDEGRLRGLETHLSYRMCLKTWSASESRNVLGTQDAYQLPNTPGAGLLQTGTGELI FT RFQTAFVSGPLRRASPSAVHPVAPPSVRPFTTHAAAPVTAGPVGGTAEVPTPTVLHAVL FT DRLVGHGPAAHQVWLPPLDEPPMLGALLRDAEPAQAELAVPIGIVDRPFEQSRVPLTID FT LSGAAGNVAVVGAPQTGKSTALRTLIMALAATHDAGRVQFYCLDFGGGALAQVDELPHV FT GAVAGRAQPQLASRMLAELESAVRFREAFFRDHGIDSVARYRQLRAKSAAESFADIFLV FT IDGWASLRQEFAALEESIVALAAQGLSFGVHVALSAARWAEIRPSLRDQIGSRIELRLA FT DPADSELDRRQAQRVPVDRPGRGLSRDGMHMVIALPDLDGVALRRRSGDPVAPPIPLLP FT ARVDYDSVVARAGDELGAHILLGLEERRGQPVAVDFGRHPHLLVLGDNECGKTAALRTL FT CREIVRTHTAARAQLLIVDFRHTLLDVIESEHMGGYVSSPAALGAKLSSLVDLLQARMP FT APDVSQAQLRARSWWSGPDIYVVVDDYDLVAVSSGNPLMVLLEYLPHARDLSLHLVVAR FT RSGGAARALFEPVLASLRDLGCRALLMSGRPDEGALFGSSRPMPLPPGRGILVTGAGDE FT QLVQVAWSPPP" FT CDS 65053..66456 FT /transl_table=11 FT /gene="Mb3478" FT /locus_tag="Mb3478" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb3478, -, len: 467 aa. Equivalent to Rv3448, len: FT 467 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 467 aa overlap). Probable conserved FT integral membrane protein, showing some similarity with FT Q9CD35|ML2529 from Mycobacterium leprae (485 aa), FASTA FT scores: opt: 371, E(): 3.6e-14, (27.25% identity in 481 aa FT overlap); and two proteins from Mycobacterium tuberculosis FT O86362|Rv0290|MTV035.18 (472 aa), FASTA scores: opt: 429, FT E(): 1.6e-17, (28.6% identity in 479 aa overlap); and FT O05457|Rv3887c|MTCY15F10.25 (509 aa), FASTA scores: opt: FT 203, E(): 0.00019, (25.6% identity in 492 aa overlap). FT Contains PS00402 Binding-protein-dependent transport FT systems inner membrane comp signature." FT /db_xref="InterPro:IPR006707" FT /db_xref="UniProtKB/TrEMBL:Q7TWH4" FT /protein_id="CAD95665.1" FT /translation="MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRG FT ASPATAARYQLSALGAPALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAA FT ALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAGLA FT ALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVL FT AMRITGCGGITLTAVACCAVVVAAATLVGAITAAPVPAIGSLDTLASFGLLEVSARMAV FT LLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLTSLLAAFAASATIGAIGTAVA FT THGIHRSSMGGIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEH FT GPWIAALTAMLAAVAMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSA FT VRHLDLTWT" FT CDS 66453..67820 FT /transl_table=11 FT /gene="Mb3479" FT /locus_tag="Mb3479" FT /product="PROBABLE SECRETED SERINE PROTEASE" FT /EC_number="3.4.21.-" FT /note="Mb3479, -, len: 455 aa. Equivalent to Rv3449, len: FT 455 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 455 aa overlap). Probable secreted FT serine protease (EC 3.4.21.-). Similar to hypothetical FT unknowns or proteases from Mycobacterium tuberculosis FT strains H37Rv and CDC1551 e.g. AAK48366|MT3998 SUBTILASE FT FAMILY PROTEIN from Mycobacterium tuberculosis strain FT CDC1551 (411 aa), FASTA scores: opt: 747, E(): 3.5e-33, FT (45.65% identity in 416 aa overlap); FT O05461|Rv3883c|MTCY15F10.29 HYPOTHETICAL PROTEIN (446 aa), FT FASTA scores: opt: 747, E(): 3.8e-33, (45.45% identity in FT 451 aa overlap); O53695|Rv0291|MTV035.19 HYPOTHETICAL FT PROTEIN (461 aa), FASTA scores: opt: 660, E(): 1.9e-28, FT (44.0% identity in 457 aa overlap); etc. And similar to FT hypothetical proteases from Mycobacterium leprae e.g. FT O33076|MLCB628.04|ML0041 HYPOTHETICAL 45.7 KDA PROTEIN FT (PROBABLE SECRETED PROTEASE) (446 aa), FASTA scores: opt: FT 683, E(): 1.1e-29, (43.8% identity in 450 aa overlap); FT Q9CD36|ML2528 PUTATIVE PROTEASE (475 aa), FASTA scores: FT opt: 608, E(): 1.3e-25, (43.0% identity in 451 aa overlap); FT Q9CBV3|ML1538 POSSIBLE PROTEASE (567 aa), FASTA scores: FT opt: 389, E(): 9.7e-14, (33.8% identity in 562 aa overlap); FT etc. Also some similarity to other proteases from several FT organisms e.g. O31788|APRX ALKALINE SERINE PROTEASE from FT Bacillus subtilis (442 aa), FASTA scores: opt: 296, E(): FT 8.3e-09, (29.4% identity in 313 aa overlap); FT O86650|SC3C3.17c PUTATIVE SECRETED SERINE PROTEASE from FT Streptomyces coelicolor (450 aa), FASTA scores: opt: 279, FT E(): 7e-08, (33.55% identity in 343 aa overlap); FT Q9KBJ7|APRX|BH193 INTRACELLULAR ALKALINE SERINE PROTEASE FT from Bacillus halodurans (444 aa), FASTA scores: opt: 257, FT E(): 1.1e-06, (28.65% identity in 335 aa overlap); FT O86642|SC3C3.08 SERINE PROTEASE from Streptomyces FT coelicolor (413 aa), FASTA scores: opt: 243, E(): 5.7e-06, FT (38.25% identity in 387 aa overlap); etc. Has putative FT signal peptide at N-terminus and hydrophobic stretch at FT C-terminus. Contains three signatures typical of subtilase FT family: aspartic acid active site (PS00136), histidine FT active site (PS00137), serine active site (PS00138)." FT /db_xref="GOA:Q7TWH3" FT /db_xref="HSSP:1BH6" FT /db_xref="InterPro:IPR000209" FT /db_xref="UniProtKB/TrEMBL:Q7TWH3" FT /protein_id="CAD95666.1" FT /translation="MTTSRTLRLLVVSALATLSGLGTPVAHAVSPPPIDERWLPESALP FT APPRPTVQREVCTEVTAESGRAFGRAERSAQLADLDQVWRLTRGAGQRVAVIDTGVARH FT RRLPKVVAGGDYVFTGDGTADCDAHGTLVAGIIAAAPDAQSDNFSGVAPDVTLISIRQS FT SSKFAPVGDPSSTGVGDVDTMAKAVRTAADLGASVINISSIACVPAAAAPDDRALGAAL FT AYAVDVKNAVIVAAAGNTGGAAQCPPQAPGVTRDSVTVAVSPAWYDDYVLTVGSVNAQG FT EPSAFTLAGPWVDVAATGEAVTSLSPFGDGTVNRLGGQHGSIPISGTSYAAPVVSGLAA FT LIRARFPTLTARQVMQRIESTAHHPPAGWDPLVGNGTVDALAAVSSDSIPQAGTATSDP FT APVAVPVPRRSTPGPSDRRALHTAFAGAAICLLALMATLATASRRLRPGRNGIAGD" FT CDS complement(67785..69197) FT /transl_table=11 FT /gene="Mb3480c" FT /locus_tag="Mb3480c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb3480c, -, len: 470 aa. Equivalent to Rv3450c, len: FT 470 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 470 aa overlap). Probable conserved FT membrane protein (possible membrane spanning region near FT N-terminus). Similar to hypothetical unknowns proteins from FT Mycobacterium leprae e.g. O33088|MLCB628.17C|ML0054 FT HYPOTHETICAL 51.9 KDA PROTEIN (PUTATIVE MEMBRANE FT PROTEIN)(481 aa), FASTA scores: opt: 708, E(): 6.4e-32, FT (32.9% identity in 480 aa overlap); Q9CD29|ML2536 (552 aa), FT FASTA scores: opt: 394, E(): 1.7e-14, (33.6% identity in FT 503 aa overlap); etc. Also similar to other proteins from FT Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. FT O69734|Rv3869|MTV027.04 (480 aa), FASTA scores: opt: 717, FT E(): 2e-32, (32.55% identity in 479 aa overlap); FT O05449|Rv3895c|MTCY15F10.17 (495 aa), FASTA scores: opt: FT 670, E(): 8.3e-30, (36.4% identity in 475 aa overlap); FT O5368|Rv0283|MTV035.11 (538 aa), FASTA scores: opt: 467, FT E(): 1.5e-18, (36.3% identity in 493 aa overlap); etc." FT /db_xref="InterPro:IPR007795" FT /db_xref="UniProtKB/TrEMBL:Q7TWH2" FT /protein_id="CAD95667.1" FT /translation="MPSPATTWLHVSGYRFLLRRIECALLFGDVCAATGALRARTTSLA FT LGCVLAIVAAMGCAFVALLRPQSALGQAPIVMGRESGALYVRVDDVWHPVLNLASARLI FT AATNANPQPVSESELGHTKRGPLLGIPGAPQLLDQPLAGAESAWAICDSDNGGSTTVVV FT GPAEDSSAQVLTAEQMILVATESGSPTYLLYGGRRAVVDLADPAVVWALRLQGRVPHVV FT AQSLLNAVPEAPRITAPRIRGGGRASVGLPGFLVGGVVRITRASGDEYYVVLEDGVQRI FT GQVAADLLRFGDSQGSVNVPTVAPDVIRVAPIVNTLPVSAFPDRPPTPVDGSPGRAVTT FT LCVTWTPAQPGAARVAFLAGSGPPVPLGGVPVTLAQADGRGPALDAVYLPPGRSAYVAA FT RSLSGGGTGTRYLVTDTGVRFAIHDDDVAHDLGLPTAAIPAPWPVLATLPSGPELSRAN FT ASVARDTVAPGP" FT CDS 69318..70106 FT /transl_table=11 FT /gene="cut3" FT /locus_tag="Mb3481" FT /product="PROBABLE CUTINASE PRECURSOR CUT3" FT /EC_number="3.1.1.-" FT /note="Mb3481, cut3, len: 262 aa. Equivalent to Rv3451, FT len: 262 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 262 aa overlap). Probable cut3, FT cutinase precursor (EC 3.1.1.-), similar to others e.g. FT Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: FT opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); FT Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia FT fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05, FT (31.45% identity in 210 aa overlap); Q9Y7G8 from FT Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203, FT E(): 8.5e-05, (31.05% identity in 190 aa overlap); FT P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA FT scores: opt: 155, E(): 0.054, (31.65% identity in 120 aa FT overlap). Similar to other proteins from Mycobacterium FT tuberculosis e.g. the downstream ORF FT O06319|Rv3452|MTCY13E12.05 HYPOTHETICAL 23.1 KDA PROTEIN FT (226 aa), FASTA scores: opt: 775, E(): 1e-37, (58.65% FT identity in 220 aa overlap); FT Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE FT CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 565, E(): FT 1.3e-25, (44.85% identity in 223 aa overlap); FT Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 PROBABLE FT CUTINASE PRECURSOR (217 aa), FASTA scores: opt: 489, E(): FT 3e-21, (47.05% identity in 221 aa overlap); etc. Equivalent FT to AAK47897 from Mycobacterium tuberculosis strain CDC1551 FT (247 aa) but longer 15 aa. Contains cutinase, serine active FT site motif (PS00155). BELONGS TO THE CUTINASE FAMILY. FT Alternative start possible at 3733. Start changed since FT first submission (+15 aa)." FT /db_xref="GOA:P0A537" FT /db_xref="HSSP:1G66" FT /db_xref="InterPro:IPR011150" FT /db_xref="UniProtKB/Swiss-Prot:P0A537" FT /protein_id="CAD95668.1" FT /translation="MNNRPIRLLTSGRAGLGAGALITAVVLLIALGAVWTPVAFADGCP FT DAEVTFARGTGEPPGIGRVGQAFVDSLRQQTGMEIGVYPVNYAASRLQLHGGDGANDAI FT SHIKSMASSCPNTKLVLGGYSQGATVIDIVAGVPLGSISFGSPLPAAYADNVAAVAVFG FT NPSNRAGGSLSSLSPLFGSKAIDLCNPTDPICHVGPGNEFSGHIDGYIPTYTTQAASFV FT VQRLRAGSVPHLPGSVPQLPGSVLQMPGTAAPAPESLHGR" FT CDS 70153..70833 FT /transl_table=11 FT /gene="cut4" FT /locus_tag="Mb3482" FT /product="PROBABLE CUTINASE PRECURSOR CUT4" FT /EC_number="3.1.1.-" FT /note="Mb3482, cut4, len: 226 aa. Equivalent to Rv3452, FT len: 226 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 226 aa overlap). Probable cut4, FT cutinase precursor (EC 3.1.1.-), similar to other e.g. FT Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: FT opt: 522, E(): 7.3e-24, (46.6% identity in 221 aa overlap); FT P30272|CUTI_MAGGR|CUT1 from Magnaporthe grisea (Rice blast FT fungus) (Pyricularia grisea) (228 aa), FASTA scores: opt: FT 205, E(): 3.8e-05, (29.25% identity in 164 aa overlap); FT Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia FT fuckeliana) (202 aa), FASTA scores: opt: 204, E(): 3.9e-05, FT (33.5% identity in 209 aa overlap); etc. Similar to other FT proteins from Mycobacterium tuberculosis e.g. upstream ORF FT O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE FT CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 773, E(): FT 1.3e-38, (59.35% identity in 209 aa overlap); FT Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE FT CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 704, E(): FT 1.3e-34, (53.4% identity in 219 aa overlap); etc. Contains FT PS00155 Cutinase, serine active site. BELONGS TO THE FT CUTINASE FAMILY. Alternative start possible at 4553 in FT cSCY13E12 but no RBS." FT /db_xref="GOA:Q7TWH1" FT /db_xref="HSSP:1G66" FT /db_xref="InterPro:IPR000675" FT /db_xref="UniProtKB/TrEMBL:Q7TWH1" FT /protein_id="CAD95669.1" FT /translation="MIPRPQPHSGRWRAGAARRLTSLVAAAFAAATLLLTPALAPPASA FT GCPDAEVVFARGTGEPPGLGRVGQAFVSSLRQQTNKSIGTYGVNYPANGDFLAAADGAN FT DASDHIQQMASACRATRLVLGGYSQGAAVIDIVTAAPLPGLGFTQPLPPAADDHIAAIA FT LFGNPSGRAGGLMSALTPQFGSKTINLCNNGDPICSDGNRWRAHLGYVPGMTNQAARFV FT ASRI" FT CDS 71105..72790 FT /transl_table=11 FT /gene="Mb3483" FT /locus_tag="Mb3483" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb3483, -, len: 561 aa. Equivalent to Rv3453 and FT Rv3454, len: 110 aa and 422 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 107 aa FT overlap and 99.8% identity in 422 aa overlap). Rv3453: FT Possible conserved transmembrane protein, showing weak FT similarity with other proteins e.g. Q9F6C3 PUTATIVE ABC FT TRANSPORTER from Propionibacterium thoenii (424 aa), FASTA FT scores: opt: 104, E(): 6.8, (40.6% identity in 69 aa FT overlap). Rv3454: Probable conserved integral membrane FT protein, showing some similarity to various proteins FT (generally transporters) e.g. Q9I5C8|PA0811 PROBABLE MFS FT TRANSPORTER from Pseudomonas aeruginosa (415 aa), FASTA FT scores: opt: 145, E(): 0.13, (28.2% identity in 188 aa FT overlap); Q01266|YHYC_PSESN HYPOTHETICAL PROTEIN IN HYUC FT 3'REGION (ORF 5) (FRAGMENT) from Pseudomonas sp. strain FT NS671 (245 aa), FASTA scores: opt: 130, E(): 0.75, (24.65% FT identity in 134 aa overlap); Q9I242|PA2073 PROBABLE FT TRANSPORTER (MEMBRANE SUBUNIT) from Pseudomonas aeruginosa FT (476 aa), FASTA scores: opt: 125, E(): 2.5, (24.6% identity FT in 252 aa overlap); etc. Equivalent to AAK47900 from FT Mycobacterium tuberculosis strain CDC1551 (562 aa) but FT shorter 140 aa. Contains PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In FT Mycobacterium bovis, a single base deletion (t-*) results FT in a single product that is more similar to Rv3454." FT /db_xref="GOA:Q7TWH0" FT /db_xref="UniProtKB/TrEMBL:Q7TWH0" FT /protein_id="CAD95670.1" FT /translation="MPGVITNSESPTAADHDRITATRETLEDYTLRLAPRSYRRWPPAV FT VGISALGGIAYLADFAIGANVGITWGTANALCGIAIFALVVFVTGLPLAYYAARYNIDL FT DLITRGSGFGYYGSVVTNVIFATFTFIFFALEGSIMAQGLKLGLHIPLWAGYACSTLII FT FPLVVYGMKVLSQLQLWTTPLWLILMAAPFGYLVVSHPDSIGQFFSYAGKDGHGGLSFG FT SVLLAAGVCLSLIAQIAEQIDYLRFMPPRTPENANRWWTWTLLAGPGWVAFGATKQIIG FT LFLAVYLMANIPGSSTIANQPVHQFMQIYRTFVPGWLALTLAVILVILSQIKINVTNAY FT SGSLAWTNSFTRLTKHYPGRVVFLGVNLAIALILMEANMFDFLNTILGCYANCGMAWVV FT AVASDIGFNKYLLGLSPKTPEFRRGMLYAINPVGFGSLLLAAGLSIVTFFGGLGAALQP FT YSPLVAIVTALVMPPILAAATKGKYYLRRTHDGIDLPMYDEHGNPSAAVLTCHVCHQDF FT ERPDMLACQTHGAHVCSLCLSTDKQAEHVLPGLARAHIPGDQVP" FT CDS complement(72752..73522) FT /transl_table=11 FT /gene="truA" FT /locus_tag="Mb3484c" FT /product="PROBABLE TRNA PSEUDOURIDINE SYNTHASE A TRUA FT (PSEUDOURIDYLATE SYNTHASE I) (PSEUDOURIDINE SYNTHASE I) FT (URACIL HYDROLYASE)" FT /EC_number="4.2.1.70" FT /note="Mb3484c, truA, len: 256 aa. Equivalent to Rv3455c, FT len: 256 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 256 aa overlap). Probable truA, FT pseudouridine synthase A (EC 4.2.1.70), equivalent to FT Q9X796|TRUA_MYCLE|ML1955|MLCB1222.25c TRNA PSEUDOURIDINE FT SYNTHASE A from Mycobacterium leprae (249 aa), FASTA FT scores: opt: 1345, E(): 3.2e-80, (77.25% identity in 246 aa FT overlap). Also highly similar to others e.g. FT O86776|TRUA_STRCO|SC6G4.09 from Streptomyces coelicolor FT (284 aa), FASTA scores: opt: 595, E(): 1.7e-31, (49.8% FT identity in 259 aa overlap); Q9RS37|DR2290 from Deinococcus FT radiodurans (280 aa), FASTA scores: opt: 383, E(): 1e-17, FT (41.2% identity in 216 aa overlap); FT Q9PJT0|TRUA_CHLMU|TC0748 from Chlamydia muridarum (267 aa), FT FASTA scores: opt: 334, E(): 1.5e-14, (37.65% identity in FT 231 aa overlap); P07649|TRUA_ECOLI|HIST|ASUC|LEUK|B2318 FT from Escherichia coli strain K12 (270 aa), FASTA scores: FT opt: 315, E(): 2.5e-13, (33.35% identity in 240 aa FT overlap); etc. BELONGS TO THE TRUA FAMILY OF PSEUDOURIDINE FT SYNTHASES." FT /db_xref="GOA:P65847" FT /db_xref="HSSP:1DJ0" FT /db_xref="InterPro:IPR020094" FT /db_xref="UniProtKB/Swiss-Prot:P65847" FT /protein_id="CAD95671.1" FT /translation="MGQRTVAGDLDAALTTIFRTPVRLRAAGRTDAGVHASGQVAHVDV FT PADALPNAYPRAGHVGDPEFLPLLRRLGRFLPADVRILDITRAPAGFDARFSALRRHYV FT YRLSTAPYGVEPQQARYITAWPRELDLDAMTAASRDLMGLHDFAAFCRHREGATTIRDL FT QRLDWSRAGTLVTAHVTADAFCWSMVRSLVGALLAVGEHRRATTWCRELLTATGRSSDF FT AVAPAHGLTLIQVDYPPDDQLASRNLVTRDVRSG" FT CDS complement(73590..74132) FT /transl_table=11 FT /gene="rplQ" FT /locus_tag="Mb3485c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L17 RPLQ" FT /note="Mb3485c, rplQ, len: 180 aa. Equivalent to Rv3456c, FT len: 180 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 180 aa overlap). Probable rplQ, 50S FT ribosomal protein L17, equivalent to FT Q9X797|RL17_MYCLE|ML1956|MLCB1222.26c 50S RIBOSOMAL PROTEIN FT L17 from Mycobacterium leprae (170 aa), FASTA scores: opt: FT 874, E(): 9.5e-45, (81.85% identity in 171 aa overlap). FT Also highly similar to other e.g. FT O86775|RL17_STRCO|SC6G4.08 from Streptomyces coelicolor FT (168 aa), FASTA scores: opt: 609, E(): 3.7e-29, (60.0% FT identity in 170 aa overlap); BAB47931|MLR0326 from FT Rhizobium loti (Mesorhizobium loti) (143 aa), FASTA scores: FT opt: 404, E(): 3.7e-17, (49.65% identity in 139 aa FT overlap); Q9Z9H5|RL17_THETH|RPLQ from Thermus aquaticus FT (subsp. thermophilus) (118 aa), FASTA scores: opt: 366, FT E(): 5.5e-15, (53.15% identity in 111 aa overlap); FT P02416|RL17_ECOLI|RPLQ|B3294 from Escherichia coli strain FT K12 (127 aa), FASTA scores: opt: 347, E(): 7.6e-14, (50.4% FT identity in 119 aa overlap); etc. BELONGS TO THE L17P FT FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5V5" FT /db_xref="HSSP:1GD8" FT /db_xref="InterPro:IPR000456" FT /db_xref="UniProtKB/Swiss-Prot:P0A5V5" FT /protein_id="CAD95672.1" FT /translation="MPKPTKGPRLGGSSSHQKAILANLATSLFEHGRITTTEPKARALR FT PYAEKLITHAKKGALHNRREVLKKLRDKDVVHTLFAEIGPFFADRDGGYTRIIKIEARK FT GDNAPMAVIELVREKTVTSEANRARRVAAAQAKAKKAAAMPTEESEAKPAEEGDVVGAS FT EPDAKAPEEPPAEAPEN" FT CDS complement(74164..75207) FT /transl_table=11 FT /gene="rpoA" FT /locus_tag="Mb3486c" FT /product="PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA FT CHAIN) RPOA (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE FT ALPHA SUBUNIT) (DNA-DIRECTED RNA NUCLEOTIDYLTRANSFERASE)" FT /EC_number="2.7.7.6" FT /note="Mb3486c, rpoA, len: 347 aa. Equivalent to Rv3457c, FT len: 347 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 347 aa overlap). Probable rpoA, alpha FT chain of RNA polymerase (EC 2.7.7.6), equivalent to FT Q9X798|RPOA_MYCLE|ML1957|MLCB1222.27c DNA-DIRECTED RNA FT POLYMERASE ALPHA from Mycobacterium leprae (347 aa), FASTA FT scores: opt: 2139, E(): 1.3e-123, (95.65% identity in 347 FT aa overlap). Also highly similar to others e.g. FT P72404|RPOA_STRCO|C6G4.07 from Streptomyces coelicolor (340 FT aa), FASTA scores: opt: 1672, E(): 4.7e-95, (75.55% FT identity in 348 aa overlap); Q9X4V6|RPOA_STRGT from FT Streptomyces granaticolor (340 aa), FASTA scores: opt: FT 1671, E(): 5.4e-95, (75.55% identity in 348 aa overlap); FT P20429|RPOA_BACSU from Bacillus subtilis (314 aa), FASTA FT scores: opt: 939, E(): 3e-50, (48.9% identity in 311 aa FT overlap); etc. Contains (PS00017) ATP/GTP-binding site FT motif A (P-loop). BELONGS TO THE RNA POLYMERASE ALPHA CHAIN FT FAMILY." FT /db_xref="GOA:P66702" FT /db_xref="HSSP:1IW7" FT /db_xref="InterPro:IPR011773" FT /db_xref="UniProtKB/Swiss-Prot:P66702" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95673.1" FT /translation="MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSS FT IPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQGPGE FT VTAGDIVPPAGVTVHNPGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRIP FT VDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVELFGLA FT RELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTES FT DLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEGAYDEQD FT YAETEQL" FT CDS complement(75355..75960) FT /transl_table=11 FT /gene="rpsD" FT /locus_tag="Mb3487c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S4 RPSD" FT /note="Mb3487c, rpsD, len: 201 aa. Equivalent to Rv3458c, FT len: 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 201 aa overlap). Probable rpsD, 30S FT ribosomal protein S4, equivalent to FT Q9X799|RS4_MYCLE|RPSD|ML1958|MLCB1222.28c 30S RIBOSOMAL FT PROTEIN S4 from Mycobacterium leprae (201 aa), FASTA FT scores: opt: 1271, E(): 2.2e-73, (93.5% identity in 201 aa FT overlap); and P45811|RS4_MYCBO|RPSD from Mycobacterium FT bovis (131 aa), FASTA scores: opt: 867, E(): 4.9e-48, FT (100.0% identity in 130 aa overlap). Also highly similar to FT others e.g. P81288|RS4_BACST|RPSD from Bacillus FT stearothermophilus (198 aa), FASTA scores: opt: 665, E(): FT 4e-35, (52.25% identity in 201 aa overlap); FT Q9K7Z8|RPSD|BH3209 from Bacillus halodurans (200 aa), FASTA FT scores: opt: 626, E(): 1.2e-32, (48.75% identity in 203 aa FT overlap); Q9X1I3|RS4_THEMA|RPSD|TM1473 from Thermotoga FT maritima (209 aa), FASTA scores: opt: 591, E(): 2e-30, FT (45.0% identity in 209 aa overlap); etc. Contains ribosomal FT protein S4 signature (PS00632) and ATP/GTP binding site FT motif (PS00017). BELONGS TO THE S4P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P45811" FT /db_xref="HSSP:1C05" FT /db_xref="InterPro:IPR002942" FT /db_xref="UniProtKB/Swiss-Prot:P45811" FT /protein_id="CAD95674.1" FT /translation="MARYTGPVTRKSRRLRTDLVGGDQAFEKRPYPPGQHGRARIKESE FT YLLQLQEKQKARFTYGVMEKQFRRYYEEAVRQPGKTGEELLKILESRLDNVIYRAGLAR FT TRRMARQLVSHGHFNVNGVHVNVPSYRVSQYDIVDVRDKSLNTVPFQIARETAGERPIP FT SWLQVVGERQRVLIHQLPERAQIDVPLTEQLIVEYYSK" FT CDS complement(75969..76388) FT /transl_table=11 FT /gene="rpsK" FT /locus_tag="Mb3488c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK" FT /note="Mb3488c, rpsK, len: 139 aa. Equivalent to Rv3459c, FT len: 139 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 139 aa overlap). Probable rpsK, 30S FT ribosomal protein S11, equivalent to FT Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL FT PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA FT scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa FT overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 FT from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, FT E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also FT highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 FT from Streptomyces coelicolor (134 aa), FASTA scores: opt: FT 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); FT O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 FT aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity FT in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus FT subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, FT (69.0% identity in 129 aa overlap); etc. Contains ribosomal FT protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY FT OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P45812" FT /db_xref="InterPro:IPR018102" FT /db_xref="UniProtKB/Swiss-Prot:P45812" FT /protein_id="CAD95675.1" FT /translation="MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTIT FT DPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQDHGVRKVDVFVKGPGSGRE FT TAIRSLQAAGLEVGAISDVTPQPHNGVRPPNRRRV" FT CDS complement(76392..76766) FT /transl_table=11 FT /gene="rpsM" FT /locus_tag="Mb3489c" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S13 RPSM" FT /note="Mb3489c, rpsM, len: 124 aa. Equivalent to Rv3460c, FT len: 124 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 124 aa overlap). Probable rpsM, 30S FT ribosomal protein S13, equivalent to FT Q9X7A1|RS13_MYCLE|RPSM|ML1960|MLCB1222.30c 30S RIBOSOMAL FT PROTEIN S13 from Mycobacterium leprae (124 aa), FASTA FT scores: opt: 762, E(): 1.5e-43, (92.75% identity in 124 aa FT overlap); and P45813|RS13_MYCBO|RPSM from Mycobacterium FT bovis (123 aa), FASTA scores: opt: 727, E(): 3e-41, (98.25% FT identity in 114 aa overlap). Also highly similar to others FT e.g. O86773|RS13_STRCO|SC6G4.05 from Streptomyces FT coelicolor (126 aa), FASTA scores: opt: 631, E(): 6.2e-35, FT (73.75% identity in 122 aa overlap); Q9RA65|RPS13 from FT Thermus aquaticus (subsp. thermophilus) (126 aa), FASTA FT scores: opt: 552, E(): 9.8e-30, (62.6% identity in 123 aa FT overlap); P20282|RS13_BACSU|RPSM from Bacillus subtilis FT (120 aa), FASTA scores: opt: 533, E(): 1.7e-28, (64245% FT identity in 121 aa overlap); etc. Contains ribosomal FT protein S13 signature (PS00646). BELONGS TO THE S13P FAMILY FT OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P45813" FT /db_xref="HSSP:1J5E" FT /db_xref="InterPro:IPR018269" FT /db_xref="UniProtKB/Swiss-Prot:P45813" FT /protein_id="CAD95676.1" FT /translation="MARLVGVDLPRDKRMEVALTYIFGIGRTRSNEILAATGIDRDLRT FT RDLTEEQLIHLRDYIEANLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGMPVRGQRTK FT TNARTRKGPKRTIAGKKKAR" FT CDS complement(76982..77095) FT /transl_table=11 FT /gene="rpmJ" FT /locus_tag="Mb3490c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L36 RPMJ" FT /note="Mb3490c, rpmJ, len: 37 aa. Equivalent to Rv3461c, FT len: 37 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 37 aa overlap). Probable rpmJ, 50S FT ribosomal protein L36, equivalent to P45810|RL36_MYCBO|RPMJ FT from Mycobacterium bovis (37 aa); and FT Q9X7A2|RL36_MYCLE|RPMJ|ML1961|MLCB1222.31c 50S RIBOSOMAL FT PROTEIN L36 from Mycobacterium leprae (37 aa), FASTA FT scores: opt: 241, E(): 9.7e-14, (86.5% identity in 37 aa FT overlap). Also highly similar to others e.g. FT O86772|RL36_STRCO|SC6G4.04 from Streptomyces coelicolor (37 FT aa), FASTA scores: opt: 233, E(): 4.5e-13, (83.8% identity FT in 37 aa overlap); P07841|RL36_BACST|RPMJ from Bacillus FT stearothermophilus (37 aa), FASTA scores: opt: 214, E(): FT 1.6e-11, (72.95% identity in 37 aa overlap); FT P12230|RK36_SPIOL|RPL36 from Spinacia oleracea (Spinach) FT (37 aa), FASTA scores: opt: 211, E(): 2.9e-11, (70.25% FT identity in 37 aa overlap); etc. Contains PS00828 Ribosomal FT protein L36 signature. BELONGS TO THE L36P FAMILY OF FT RIBOSOMAL PROTEINS." FT /db_xref="GOA:P0A5W7" FT /db_xref="HSSP:1DFE" FT /db_xref="InterPro:IPR000473" FT /db_xref="UniProtKB/Swiss-Prot:P0A5W7" FT /protein_id="CAD95677.1" FT /translation="MKVNPSVKPICDKCRLIRRHGRVMVICSDPRHKQRQG" FT CDS complement(77128..77349) FT /transl_table=11 FT /gene="infA" FT /locus_tag="Mb3491c" FT /product="PROBABLE TRANSLATION INITIATION FACTOR IF-1 INFA" FT /note="Mb3491c, infA, len: 73 aa. Equivalent to Rv3462c, FT len: 73 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 73 aa overlap). Probable infA, FT initiation factor IF-1, equivalent to P45957|ML1962|INFA FT TRANSLATION INITIATION FACTOR IF-1 from Mycobacterium bovis FT (72 aa) and Mycobacterium leprae (72 aa), FASTA scores: FT opt: 472, E(): 6.6e-28, (100.0% identity in 72 aa overlap). FT Also highly similar to others e.g. FT O54209|IF1_STRCO|INFA|SC6G4.03 from Streptomyces coelicolor FT (73 aa), FASTA scores: opt: 424, E(): 2e-24, (84.95% FT identity in 73 aa overlap); O50630|IF1_BACHD|INFA|BH0158 FT from Bacillus halodurans (71 aa), FASTA scores: opt: 388, FT E(): 8.1e-22, (77.8% identity in 72 aa overlap); FT Q9XD14|IF1_LEPIN|INFA from Leptospira interrogans (71 aa), FT FASTA scores: opt: 376, E(): 6e-21, (80.0% identity in 70 FT aa overlap); etc. CONTAINS 1 'S1 MOTIF' DOMAIN. BELONGS TO FT THE IF-1 FAMILY." FT /db_xref="GOA:P0A5H6" FT /db_xref="HSSP:1AH9" FT /db_xref="InterPro:IPR004368" FT /db_xref="UniProtKB/Swiss-Prot:P0A5H6" FT /protein_id="CAD95678.1" FT /translation="MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQHY FT IRILPEDRVVVELSPYDLSRGRIVYRYK" FT CDS 77603..78460 FT /transl_table=11 FT /gene="Mb3492" FT /locus_tag="Mb3492" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3492, -, len: 285 aa. Equivalent to Rv3463, len: FT 285 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 285 aa overlap). Conserved hypothetical FT protein, similar to Q9RDA2|SCE20.23 HYPOTHETICAL 31.4 KDA FT PROTEIN from Streptomyces coelicolor (290 aa), FASTA FT scores: opt: 770, E(): 2.2e-41, (48.6% identity in 247 aa FT overlap); and Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE from FT Streptomyces coelicolor (341 aa), (see BLASTP results), FT FASTA scores: opt: 119, E(): 2.9, (24.1% identity in 274 aa FT overlap)." FT /db_xref="InterPro:IPR019922" FT /db_xref="UniProtKB/TrEMBL:Q7TWG8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95679.1" FT /translation="MTNCAAGKPSSGPNLGRFGSFGRGVTPQQATEIEALGYGAVWVGG FT SPPAALSWVEPILQATTTLCVATGIVNIWSAPAQRVAESFHRIEAAYPGRFLLGIGVGH FT AEMISEYRKPYNALVEYLDRLDDYGVPANRRVVAALGPRVLGLSARRSAGAHPYLTTPE FT HTARARELIGPSAFLAPEHKVVLTTDSARARTVGRQALDMYFNLANYRNNWKRLGFTDD FT EVSRPGSDRLVDAVVAYGTPDAIAARLNEHLLAGADHVPIQVLTEDDNLVSALTELAKP FT LRLT" FT CDS 78533..79528 FT /transl_table=11 FT /gene="rmlB1" FT /locus_tag="Mb3493" FT /standard_name="rfbB" FT /product="PROBABLE DTDP-GLUCOSE 4,6-DEHYDRATASE RMLB1" FT /EC_number="4.2.1.46" FT /note="Mb3493, rmlB1, len: 331 aa. Equivalent to Rv3464, FT len: 331 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 331 aa overlap). Probable rmlB1 FT (alternate gene name: rfbB), DTDP-glucose-4,6-dehydratase FT (EC 4.2.1.46), nearly identical to Q50556|RMLB rhamnose FT biosynthesis protein (EC 4.2.1.46) from Mycobacterium FT tuberculosis (329 aa) (previously rfbB, now known as rmlB). FT Equivalent to Q9CBH7|RMLB|ML1964 DTDP-GLUCOSE FT 4,6-DEHYDRATASE (alias Q9X7A3|RMLB PUTATIVE DTDP-(GLUCOSE FT OR RHAMNOSE)-4,6-DEHYDRATASE (331 aa)) from Mycobacterium FT leprae (333 aa), FASTA scores: opt: 1925, E(): 1.9e-112, FT (84.0% identity in 331 aa overlap). Also highly similar to FT others e.g. Q9UZH2|RFBB|PAB0785 from Pyrococcus abyssi (333 FT aa), FASTA scores: opt: 1115, E(): 4.2e-62, (51.55% FT identity in 322 aa overlap); O27817|MTH1789 from FT Methanobacterium thermoautotrophicum (336 aa), FASTA FT scores: opt: 1104, E(): 2.1e-61, (51.65% identity in 331 aa FT overlap); BAB60064|TVG0950610 from Thermoplasma volcanium FT (318 aa), FASTA scores: opt: 1102, E(): 2.6e-61, (49.65% FT identity in 310 aa overlap); etc. Also related to FT P72050|MTCY13D12.18|RV3784 HYPOTHETICAL 36.3 KDA PROTEIN FT (SIMILAR TO GALACTOWALDENASES FROM EUKARYOTIC AND FT PROKARYOTIC ORIGIN) from Mycobacterium tuberculosis (326 FT aa), FASTA scores: E(): 1.4e-26, (33.8% identity in 320 aa FT overlap)." FT /db_xref="GOA:Q7TWG7" FT /db_xref="HSSP:1KEP" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TWG7" FT /protein_id="CAD95680.1" FT /translation="MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLA FT DVEDAIRLVQGDITDAELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTI FT LEAVRRHGVRLHHISTDEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVR FT SYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSA FT VRRILDRGRIGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDP FT STLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERGQ" FT CDS 79530..80138 FT /transl_table=11 FT /gene="rmlC" FT /locus_tag="Mb3494" FT /standard_name="rfbC" FT /product="PROBABLE DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE FT RMLC (DTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) FT (DTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE FT DIPHOSPHO-4-KETORHAMNOSE 3,5-EPIMERASE)" FT /EC_number="5.1.3.13" FT /note="Mb3494, rmlC, len: 202 aa. Equivalent to Rv3465, FT len: 202 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 202 aa overlap). Probable rmlC FT (alternate gene name: rfbC), dtdp-4-dehydrorhamnose FT 3,5-epimerase (EC 5.1.3.13), nearly identical to FT O33170|RMLC RMLC PROTEIN from Mycobacterium tuberculosis FT (203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5% FT identity in 200 aa overlap) (previously known as rfbC). FT Equivalent to Q9X7A4|RMLC|ML1965 PUTATIVE FT DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE from Mycobacterium FT leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64, FT (75.4% identity in 199 aa overlap). Also highly similar to FT others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis (198 FT aa), FASTA scores: opt: 671, E(): 7e-38, (51.3% identity in FT 193 aa overlap); Q9L6C5 from Streptomyces antibioticus (202 FT aa), FASTA scores: opt: 665, E(): 1.8e-37, (49.25% identity FT in 197 aa overlap); P29783|STRM_STRGR from Streptomyces FT griseus (200 aa), FASTA scores: opt: 608, E(): 1.2e-33, FT (49.25% identity in 201 aa overlap); Q54265|STRM from FT Streptomyces glaucescens (200 aa), FASTA scores: opt: 603, FT E(): 2.5e-33, (46.7% identity in 197 aa overlap); etc. Also FT highly similar to Q9S4D4|TYLJ PUTATIVE NDP-HEXOSE FT 3-EPIMERASE from Streptomyces fradiae (205 aa), FASTA FT scores: opt: 625, E(): 8.6e-35, (45.9% identity in 194 aa FT overlap)." FT /db_xref="GOA:Q7TWG6" FT /db_xref="HSSP:1DZR" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:Q7TWG6" FT /protein_id="CAD95681.1" FT /translation="MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDV FT RQVNCSVSSAGVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDSVLLD FT DQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNPQREHTICATDPTLAVDWPLVDGA FT APSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGEMRGT" FT CDS 80221..80889 FT /transl_table=11 FT /gene="Mb3495" FT /locus_tag="Mb3495" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3495, -, len: 222 aa. Equivalent to Rv3466, len: FT 222 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.2% identity in 222 aa overlap). Conserved hypothetical FT ORF in REP13E12 repeat, but extending 5' of repeat. Has FT segment of identity to other REP13E12 ORF's e.g. FT MTCY336.16, MTCI65.15c, MTCY09F9.19, cMTCY251.14c." FT /db_xref="UniProtKB/TrEMBL:Q7TWG5" FT /protein_id="CAD95682.1" FT /translation="MGSGSRERIVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLEC FT LVRRLPAVGHTLINQLDTQASEEELGGTLCCALANRLRITKPDAALRIADAADLGPRRA FT LTGEPLAPQLTATATAQRQGLIGEAHIKVIRALFRPPARRGGCVHPPGRRSRPGRQSRS FT ISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL FT " FT repeat_region 80221..81613 FT /locus_tag="REP-8" FT /rpt_family="REP" FT /note="REP-8, len: 1393 nt. Equivalent to REP, len: 1372 FT nt, from Mycobacterium tuberculosis strain H37Rv, (98.8% FT identity in 1368 nt overlap). REP13E12, 1371 bp repeat, FT copies in Mycobacterium tuberculosis cosmids; cY336 from: FT 14471 to: 15821 (approx. 100% identity); cY251 from: 11693 FT to: 13109 (approx. 100% identity); cI65 from: 14515 to: FT 15905 (approx 75% identity); cI125 from: 27240 to: 28597 FT (approx. 65% Identity); cY22G8 from: 13352 to 14689 FT (approx. 65% identity); and cY9F9 from: 9019 to: 10451 FT (approx. 65% identity); also nearly identical to EM_BA FT :MB35021 U35021 Mycobacterium bovis BCG DNA flanking FT deletion region 3 from: 56 to: 1466." FT CDS 80660..81613 FT /transl_table=11 FT /gene="Mb3496" FT /locus_tag="Mb3496" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3496, -, len: 317 aa. Equivalent to Rv3467, len: FT 317 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.1% identity in 317 aa overlap). Conserved hypothetical FT ORF in REP13E12 repeat, identical to ORF's from other FT REP13E12 copies e.g. MTCY251.13c, MTCI65.15c, MTCY09F9.19, FT cMTCY336.17. Also identical to Mycobacterium bovis Q50655 FT HYPOTHETICAL 34.6 KD PROTEIN (317 aa) in identical repeat." FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:Q7TWG4" FT /protein_id="CAD95683.1" FT /translation="MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTER FT ARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTPDA FT AAIDRDTRSQAQRNHDGLLAGLRALIASGELGQHNGLPVSIVVTTTLTDLQTGAGKGFT FT GGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFAN FT DRGCTKPGCDAPAYHSQAHHVTGWTSTGRTDITELTLACDPDNRLAEKGWTTRKNTHGH FT TEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDEPD" FT CDS complement(81671..82765) FT /transl_table=11 FT /gene="rmlB2" FT /locus_tag="Mb3497c" FT /standard_name="rfbB" FT /product="POSSIBLE DTDP-GLUCOSE 4,6-DEHYDRATASE RMLB2" FT /EC_number="4.2.1.46" FT /note="Mb3497c, rmlB2, len: 364 aa. Equivalent to Rv3468c, FT len: 364 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 364 aa overlap). Possible rmlB2 FT (alternate gene name: rfbB), DTDP-glucose-4,6-dehydratase FT (EC 4.2.1.46), similar to others e.g. O08246|MTME from FT Streptomyces argillaceus (331 aa), FASTA scores: opt: 238, FT E(): 1.2e-07, (29.65% identity in 344 aa overlap); FT Q9LFG7|F4P12_220 from Arabidopsis thaliana (Mouse-ear FT cress) (433 aa), FASTA scores: opt: 237, E(): 1.8e-07, FT (27.25% identity in 308 aa overlap); Q9LZI2|F26K9_260 from FT Arabidopsis thaliana (Mouse-ear cress) (445 aa), FASTA FT scores: opt: 225, E(): 1e-06, (25.95% identity in 335 aa FT overlap); etc. Also similar to various enzymes and FT hypothetical unknowns proteins e.g. BAB48655|MLL1234 FT UDP-GLUCOSE 4-EPIMERASE from Rhizobium loti (Mesorhizobium FT loti) (307 aa), FASTA scores: opt: 757, E(): 4.6e-40, FT (43.4% identity in 302 aa overlap). First start taken, FT alternative at 17080 in cSCYY13E12 suggested by similarity. FT Note that previously known as rmlB3." FT /db_xref="GOA:Q7TWG3" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TWG3" FT /protein_id="CAD95684.1" FT /translation="MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSG FT HLGEALVRTLRARGADVVSLDSRPSRYTNIVGCVSDRALLRDVMAGVEVVFHAAAHHKP FT QLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAWIDE FT SVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNI FT KANEYACRRVALEDAVDAHLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFA FT RRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQSVHTPL FT SQLVGSKAYAHSSYHRGVFAPARP" FT CDS complement(82769..83779) FT /transl_table=11 FT /gene="mhpE" FT /locus_tag="Mb3498c" FT /product="PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE MHPE FT (HOA)" FT /EC_number="4.1.3.-" FT /note="Mb3498c, mhpE, len: 336 aa. Equivalent to Rv3469c, FT len: 336 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 336 aa overlap). Probable mhpE, FT 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), similar to FT others (principally from Pseudomonas species) e.g. FT Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338 FT aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65% identity FT in 332 aa overlap); Q9X9Q0|NIKB NIKB PROTEIN (see first FT citation below) from Streptomyces tendae (357 aa), FASTA FT scores: opt: 571, E(): 4.4e-28, (34.5% identity in 339 aa FT overlap); P51014|BPHF_PSES1 from Pseudomonas sp. strain FT KKS102 (352 aa), FASTA scores: opt: 549, E(): 9.9e-27, FT (31.2% identity in 314 aa overlap); Q51983|CMTG_PSEPU from FT Pseudomonas putida (350 aa), FASTA scores: opt: 543, E(): FT 2.3e-26, (30.7% identity in 319 aa overlap); FT P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain FT K12 (337 aa), FASTA scores: opt: 517, E(): 9.1e-25, (31.75% FT identity in 312 aa overlap); etc. Also similar to FT P71867|MTCY03C7.22|Rv3534c HYPOTHETICAL 36.4 KDA PROTEIN FT from Mycobacterium tuberculosis (346 aa), FASTA scores: FT E(): 7.5e-24, (31.9% identity in 310 aa overlap)." FT /db_xref="GOA:Q7TWG2" FT /db_xref="InterPro:IPR000891" FT /db_xref="UniProtKB/TrEMBL:Q7TWG2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95685.1" FT /translation="MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGI FT PYIEIGHGVTIGAAAAQGPAAHTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGD FT YLDFLRICVIATEFELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVR FT IVYVVDTTGTFLPEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDG FT TLMGFGRGAGNCQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEIS FT FGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVGMRA" FT CDS complement(83840..85498) FT /transl_table=11 FT /gene="ilvB2" FT /locus_tag="Mb3499c" FT /product="PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) FT ILVB2 (AHAS) (ACETOHYDROXY-ACID SYNTHASE LARGE SUBUNIT) FT (ALS)" FT /EC_number="2.2.1.6" FT /note="Mb3499c, ilvB2, len: 552 aa. Equivalent to Rv3470c, FT len: 552 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 552 aa overlap). Probable ilvB2, FT acetolactate synthase large subunit (EC 4.1.3.18), similar FT to others e.g. P73913|ILVG|SLR2088 from Synechocystis sp. FT strain PCC 6803 (621 aa), FASTA scores: opt: 779, E(): FT 4.5e-39, (30.7% identity in 567 aa overlap); FT O78518|ILVB_GUITH from Guillardia theta (Cryptomonas phi) FT (575 aa), FASTA scores: opt: 742, E(): 6.9e-37, (28.8% FT identity in 566 aa overlap); Q59950|ILVX from Spirulina FT platensis (612 aa), FASTA scores: opt: 715, E(): 3e-35, FT (28.45% identity in 569 aa overlap); etc. Contains thiamine FT pyrophosphate enzymes signature (PS00187)." FT /db_xref="GOA:Q7TWG1" FT /db_xref="HSSP:1JSC" FT /db_xref="InterPro:IPR012000" FT /db_xref="UniProtKB/TrEMBL:Q7TWG1" FT /protein_id="CAD95686.1" FT /translation="MTVGDHLVARMRAAGISVVCGLPTSRLDSLLVRLSRDAGFQIVLA FT RHEGGAGYLADGFARASGKSAAVFVAGPGATNVISAVANASVNQVPMLILTGEVAVGEF FT GLHSQQDTSDDGLGLGATFRRFCRCSVSIESIANARSKIDSAFRALASIPRGPVHIALP FT RDLVDERLPAHQLGTAAAGLGGLRTLAPCGPDVADEVIGRLDRSRAPMLVLGNGCRLDG FT IGEQIVAFCEKAGLPFATTPNGRGIVAETHPLSLGVLGIFGDGRADEYLFDTPCDLLIA FT VGVSFGGLVTRSFSPRWRGLKADVVHVDPDPSAVGRFVATSLGITTSGRAFVNALNCGR FT PPRFCRRVGVRPPAPAALPGTPQARGESIHPLELMHELDRELAPNATICADVGTCISWT FT FRGIPVRRPGRFFATVDFSPMECGIAGAIGVALARPEEHVICIAGDGAFLMHGTEISTA FT VAHGIRVTWAVLNDGQMSASAGPVSGRMDPSPVARIGANDLAAMARALGAEGIRVDTRC FT ELRAGVQKALAATGPCVLDIAIDPEINKPDIGLGR" FT CDS complement(85504..86037) FT /transl_table=11 FT /gene="Mb3500c" FT /locus_tag="Mb3500c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3500c, -, len: 177 aa. Equivalent to Rv3471c, len: FT 177 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 177 aa overlap). Conserved hypothetical FT protein, similar to Q59013|MJ1618 HYPOTHETICAL PROTEIN from FT Methanococcus jannaschii (125 aa), FASTA scores: opt: 262, FT E(): 1.2e-09, (39.05% identity in 105 aa overlap); and FT O26452|MTH352 CONSERVED PROTEIN from Methanobacterium FT thermoautotrophicum (131 aa), FASTA scores: opt: 222, E(): FT 3.8e-07, (35.05% identity in 117 aa overlap). Equivalent to FT AAK47934 from Mycobacterium tuberculosis strain CDC1551 FT (184 aa) but shorter 7 aa." FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:Q7TWG0" FT /protein_id="CAD95687.1" FT /translation="MSTRPERERASTSTDAVLQATVALSAGHKPAFRGFVKDPPRARAH FT AAAMFVSNAREAEPFVAPDLSEIRVLVDRATVGVASVSLAHATVAAGAETVWHRLQATD FT EIYFVLSGRGLVSVGDESGEVGPGDAVWIPAGVPQKIRALGSVPLTFLCAWGPAYLPER FT DQRMGEAAVIGAWP" FT CDS 86058..86564 FT /transl_table=11 FT /gene="Mb3501" FT /locus_tag="Mb3501" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3501, -, len: 168 aa. Equivalent to Rv3472, len: FT 168 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 168 aa overlap). Conserved hypothetical FT protein, showing some similarity to other proteins e.g. FT Q9ZAT9|DPSH DAUNORUBICIN BIOSYNTHESIS ENZYME from FT Streptomyces peucetius (194 aa), FASTA scores: opt: 181, FT E(): 6.8e-05, (30.7% identity in 127 aa overlap); Q53879 FT DAUH/E from Streptomyces sp. C5 (151 aa), FASTA scores: FT opt: 168, E(): 0.00038, (29.25% identity in 127 aa FT overlap); and Q9L4U3|AKNV from Streptomyces galilaeus (144 FT aa), FASTA scores: opt: 122, E(): 0.36, (31.25% identity in FT 129 aa overlap)." FT /db_xref="InterPro:IPR011944" FT /db_xref="UniProtKB/TrEMBL:Q7TWF9" FT /protein_id="CAD95688.1" FT /translation="MRPVDEQWIEILRIQALCARYCLTIDTQDGEGWAGCFTEDGAFEF FT DGWVIRGRPALREYADAHARVVRGRHLTTDLLYEVDGDVATGRSASVVTLATAAGYKIL FT GSGEYQDRLIKQDGQWRIAYRRLRNDRLVSDPSVAVNVADADVAAVVGHLLAAARRLGT FT QMSDT" FT CDS complement(86644..87429) FT /transl_table=11 FT /gene="bpoA" FT /locus_tag="Mb3502c" FT /product="POSSIBLE PEROXIDASE BPOA (NON-HAEM PEROXIDASE)" FT /EC_number="1.11.1.-" FT /note="Mb3502c, bpoA, len: 261 aa. Equivalent to Rv3473c, FT len: 261 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 261 aa overlap). Possible bpoA, FT peroxidase (non-haem peroxidase) (EC 1.11.1.-), similar to FT various enzymes or hypothetical unknown proteins e.g. FT O85849 HYPOTHETICAL 26.2 KDA PROTEIN from Sphingomonas FT aromaticivorans (247 aa), FASTA scores: opt: 684, E(): FT 4.9e-34, (43.8% identity in 242 aa overlap); FT AAK45412|MT1155 HYDROLASE, ALPHA/BETA HYDROLASE FOLD FAMILY FT from Mycobacterium tuberculosis strain CDC1551 (311 aa), FT FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 FT aa overlap); Q9K3V0|SCD10.27 PUTATIVE HYDROLASE from FT Streptomyces coelicolor (352 aa), FASTA scores: opt: 248, FT E(): 9.7e-08, (26.05% identity in 261 aa overlap); FT P29715|BPA2_STRAU|BPOA2 NON-HAEM BROMOPEROXIDASE (EC FT 1.11.1.-) (BROMIDE PEROXIDASE) (277 aa), FASTA scores: opt: FT 237, E(): 3.6e-07, (29.45% identity in 265 aa overlap); FT O31168|PRXC_STRAU|CPO|CPOT NON-HEME CHLOROPEROXIDASE (EC FT 1.11.1.10) (278 aa), FASTA scores: opt: 236, E(): 4.2e-07, FT (29.45% identity in 265 aa overlap); AAK62388|T5L19.180 FT LIPASE-LIKE PROTEIN from Arabidopsis thaliana (Mouse-ear FT cress) (350 aa), FASTA scores: opt: 236, E(): 5.1e-07, FT (26.65% identity in 274 aa overlap); etc. Also similar to FT O06575|BPOB|Rv1123c|MTCY22G8.12c HYPOTHETICAL 32.5 KDA FT PROTEIN from Mycobacterium tuberculosis (302 aa), FASTA FT scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa FT overlap). Equivalent to AAK47936 from Mycobacterium FT tuberculosis strain CDC1551 (294 aa) but shorter 33 aa. May FT have been inactivated or truncated by neighbouring IS6110." FT /db_xref="GOA:Q7TWF8" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7TWF8" FT /protein_id="CAD95689.1" FT /translation="MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEG FT DYRLVSFAGDIQEVLRNLPGQPALVGASLGGFAAMLLAGELSPGIASAVVLVDIVPNMD FT LAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSDPDGLVANLRRRGDRWYWH FT WDPQFIGGIAAFPPVEVTDVDRMNAAVATILRDEVPVLLVRGQVSDIVRQESADQFLSR FT FPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR" FT CDS complement(87709..89058) FT /transl_table=11 FT /gene="kgtP" FT /locus_tag="Mb3503c" FT /product="PROBABLE DICARBOXYLIC ACID TRANSPORT INTEGRAL FT MEMBRANE PROTEIN KGTP (DICARBOXYLATE TRANSPORTER)" FT /note="Mb3503c, kgtP, len: 449 aa. Equivalent to Rv3476c, FT len: 449 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 449 aa overlap). Probable kgtP, FT dicarboxylate-transport integral membrane protein, possibly FT member of major facilitator superfamily (MFS), highly FT similar to others e.g. Q9HT43|PA5530 from Pseudomonas FT aeruginosa (435 aa), FASTA scores: opt: 1209, E(): 2.3e-68, FT (47.05% identity in 425 aa overlap); Q9I6Q9|PCAT|PA0229 FT from Pseudomonas aeruginosa (432 aa), FASTA scores: opt: FT 1131, E(): 1.8e-63, (40.4% identity in 438 aa overlap); FT Q9WWZ2 from Pseudomonas putida (429 aa), FASTA scores: opt: FT 1090, E(): 6.5e-61, (41.2% identity in 425 aa overlap); FT P17448|KGTP_ECOLI|WITA|B2587 from Escherichia coli strain FT K12 (432 aa), FASTA scores: opt: 1083, E(): 1.8e-60, FT (40.05% identity in 422 aa overlap); etc. Also similar to FT O05301|MTCI364.12|Rv1200 HYPOTHETICAL 44.6 KDA PROTEIN from FT Mycobacterium tuberculosis (425 aa), FASTA scores: E(): FT 5.2e-25, (28.5% identity in 382 aa overlap). Contains sugar FT transport protein signatures 1 and 2 (PS00216, PS00217). FT BELONG TO THE SUGAR TRANSPORTER FAMILY." FT /db_xref="GOA:Q7TWF7" FT /db_xref="InterPro:IPR005828" FT /db_xref="UniProtKB/TrEMBL:Q7TWF7" FT /protein_id="CAD95690.1" FT /translation="MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFAT FT YFEDQFFDRADRNSTVYVYAIFAVTFVTRPVGSWFFGRFADRRGRRAALTFSVSLMAAC FT SLIVALVPSRSSIGVAAPILLILCRLVQGFATGGEYGTSVTYMSEAATRERRGYFSSFQ FT YVTLVGGHVLAQFTLLVILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQ FT ERLTAIKAGRDHDSGSLRELATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYGS FT QAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWFGVGGLIYTYVLVTYLPETRS FT PTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVGVGYALANSVFGGTAPLIYQ FT ALKERDQVPMFIAYVTACIAVSLIVYVFFIKNKADTYLDREQGFAFYGHA" FT CDS 89431..89727 FT /transl_table=11 FT /gene="PE31" FT /locus_tag="Mb3504" FT /product="PE FAMILY PROTEIN" FT /note="Mb3504, PE31, len: 98 aa. Equivalent to Rv3477, len: FT 98 aa, from Mycobacterium tuberculosis strain H37Rv, (99.0% FT identity in 98 aa overlap). Member of the M. tuberculosis FT PE family, similar to O53941|Rv1791|MTV049.13 (99 aa), FT FASTA scores: opt: 373, E(): 4.3e-18, (64.65% identity in FT 99 aa overlap); MTCI364.07; MTCY21C12.10c; MTCY1A11.25c; FT MTC1A11.04; MTCY359.33; etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TWF6" FT /protein_id="CAD95691.1" FT /translation="MSFTAQPEMLAAAAGELRSLGATLKVSNAAAAVPTTGVVPPAADE FT VSLLLATQFRTHAATYQTASAKAAVIHEQFVTTLATSASSYADTEAANAVVTG" FT CDS 89764..90945 FT /transl_table=11 FT /gene="PPE60" FT /locus_tag="Mb3505" FT /standard_name="mtb39c" FT /product="PE FAMILY PROTEIN" FT /note="Mb3505, PPE60, len: 393 aa. Equivalent to Rv3478, FT len: 393 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 393 aa overlap). PPE60 (alternate gene FT name: mtb39c). Member of the M. tuberculosis PPE family, FT highly similar to others e.g. FT Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396 aa), FT FASTA scores: opt: 2165, E(): 1.1e-109, (85.35% identity in FT 396 aa overlap); MTCI364.08; MTCY10G2.10; MTCY03A2.22c; FT MTCY274.23c; MTCY164.34c; MTCY98.0029c; etc. Note that FT expression of Rv3478 was demonstrated in lysates by FT immunodetection (see citation below)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TWF5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95692.1" FT /translation="MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAASA FT FQSVVWGLTVGSWIGSSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRL FT TVPPPVIAENRTELMTLTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATAT FT EALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSS FT KLGGLWTAVSPHLSPLSNVSSIANNHMSMMGTGVSMTNTLHSMLKGLAPAAAQAVETAA FT ENGVWAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARA FT LPLTSLTSAAQTAPGHMLGGLPLGHSVNAGSGINNALRVPARAYAIPRTPAAG" FT CDS 91158..92459 FT /transl_table=11 FT /gene="Mb3507" FT /locus_tag="Mb3507" FT /product="HYPOTHETICAL PROTEIN [FIRST PART]" FT /note="Mb3507, -, len: 433 aa. Equivalent to 5' end of FT Rv3479, len: 1075 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.8% identity in 418 aa overlap). Possible FT transmembrane protein, with hydrophobic stretches at FT C-terminus. Start changed since first submission (-54 aa). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv3479 exists as a single gene. FT In Mycobacterium bovis, a 713 bp deletion splits Rv3479 FT into 2 parts, Mb3507 and Mb3508." FT /db_xref="GOA:Q7TWF4" FT /db_xref="InterPro:IPR019894" FT /db_xref="UniProtKB/TrEMBL:Q7TWF4" FT /protein_id="CAD95693.1" FT /translation="MAGVTREINLLAQASQWRRLGGTFPTNSQLTNESAASLRLYAQLI FT DLLDMVVDVDILSGTSAGGINAALLASSRVTGSDLGGIRDLWLDLGALTELLRDPRDKK FT TPSLLYGDERIFAALAKRLPKLATGPFPPTTFPEAARTPSTTLYITTTLLAGETSRFTD FT SFGTLVQDVDRRGLFTFTETDLARPDTAPALALAARSSASFPLAFEPSFLPFTKGTAKK FT GEVPARPAMAPFTSLTRPHWVSDGGLLDNRPIGVLFKRIFDRPARRPVRRVLLFVVPSS FT GPAPDPMHEPPPDNVDEPLGLIDGLLKGLAAVTTQSIAADLRAIRAHQDCMEARTDAKL FT RLAELAATLRNGTRLLTPSLLTDYRTREATKQAQTLTSALLRRLSTCPPESGPATESLP FT KSWSAELTVGGDADKVCRQLASFRCVLQEVMASQ" FT CDS 92464..93510 FT /transl_table=11 FT /gene="Mb3508" FT /locus_tag="Mb3508" FT /product="HYPOTHETICAL TRANSMEMBRANE PROTEIN [SECOND PART]" FT /note="Mb3508, -, len: 348 aa. Equivalent to 3' end of FT Rv3479, len: 1075 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.7% identity in 348 aa overlap). Possible FT transmembrane protein, with hydrophobic stretches at FT C-terminus. Start changed since first submission (-54 aa). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv3479 exists as a single gene. FT In Mycobacterium bovis, a 713 bp deletion splits Rv3479 FT into 2 parts, Mb3507 and Mb3508." FT /db_xref="GOA:Q7TWF3" FT /db_xref="UniProtKB/TrEMBL:Q7TWF3" FT /protein_id="CAD95694.1" FT /translation="MWGRLDGAGWLVHVLLDPRRVRWIVGERADTNGPQSGAQWFLGKL FT KELGAPDFPSPGYPLPAVGGGPAQHLTEDMLLDELGFLDDPAKPLPASIPWTALWLSQA FT WQQRVLEEELDGLANTVLDPQPGKLPDWSPTSSRTWATKVLAAHPGDAKYALLNENPIA FT GETFASDKGSPLMAHTVAKAAATAAGAAGSVRQLPSVLKPPLITLRTLTLSGYRVVSLT FT KGIARSTIIAGALLLVLGVAAAIQSVTVFGVTGLIAAGTGGLLVVLGTWQVSGRLLFAL FT LSFSVVGAVLALATPVVREWLFGTQQQPGWVGTHAYWLGAQWWHPLVVVGLIALVAIMI FT AAANPGRR" FT CDS complement(93534..94358) FT /transl_table=11 FT /gene="Mb3509c" FT /locus_tag="Mb3509c" FT /product="CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]" FT /note="Mb3509c, -, len: 274 aa. Equivalent to 3' end of FT Rv3480c, len: 497 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 274 aa overlap). FT Conserved hypothetical protein, similar to many from FT Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. FT O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa), FT FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in 488 FT aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa), FT FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in FT 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA scores: FT opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); FT etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED FT MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA FT scores: opt: 272, E(): 1e-08, (28.85% identity in 485 aa FT overlap); and Q9RIU8|CM11.13c HYPOTHETICAL 47.1 KDA PROTEIN FT from Streptomyces coelicolor (446 aa), FASTA scores: opt: FT 254, E(): 1.1e-07, (30.4% identity in 497 aa overlap). FT SEEMS TO BELONG TO THE UPF0089 FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv3480c exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a 2 bp deletion FT (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/TrEMBL:Q7TWF2" FT /protein_id="CAD95695.1" FT /translation="MAGAGRSTFELTKALVNAQLRSDHEYRNLVGSVQAPHCILNTRIS FT RNRRFATQQYPLDRLKAIGAQYDATINDVALAIIGGGLRRFLDELGELPNKSLIVVLPV FT NVRPKDDEGGGNAVATILATLGTDVADPVQRLAAVTASTRAAKAQLRSMDKDAILAYSA FT ALMAPYGVQLASTLSGVKPPWPYTFNLCVSNVPGPEDVLYLRGSRMEASYPVSLVAHSQ FT ALNVTLQSYAGTLNFGFIGCRDTLPHLQRLAVYTGEALDQLAAADGAAGLGS" FT CDS complement(94372..95025) FT /transl_table=11 FT /gene="Mb3510c" FT /locus_tag="Mb3510c" FT /product="CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]" FT /note="Mb3510c, -, len: 217 aa. Equivalent to 5' end of FT Rv3480c, len: 497 aa, from Mycobacterium tuberculosis FT strain H37Rv, (98.6% identity in 216 aa overlap). Conserved FT hypothetical protein, similar to many from Mycobacterium FT tuberculosis strains H37Rv and CDC1551 e.g. FT O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa), FT FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in 488 FT aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa), FT FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in FT 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA scores: FT opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); FT etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED FT MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA FT scores: opt: 272, E(): 1e-08, (28.85% identity in 485 aa FT overlap); and Q9RIU8|CM11.13c HYPOTHETICAL 47.1 KDA PROTEIN FT from Streptomyces coelicolor (446 aa), FASTA scores: opt: FT 254, E(): 1.1e-07, (30.4% identity in 497 aa overlap). FT SEEMS TO BELONG TO THE UPF0089 FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv3480c exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a 2 bp deletion FT (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/TrEMBL:Q7TWF1" FT /protein_id="CAD95696.1" FT /translation="MSQTARRLGPQDMFFLYSESSTTMMHVGALMPFTPPSGAPPDLLR FT QLVDESKASEVVEPWSLRLSHPELLYHPTQSWVVDDNFDLDYHVRRSALASPGDERELG FT IPVSRLHSHALDLRRPPWEVHFIEGLEGGRFAIYIKMHHSLIDGYTGQKMLARSLSTDP FT HDTTHPLFFNIPTPGRSPADTQDSVGGGLIAGAGNVLDGLGDVVRGLGGRQRGR" FT CDS complement(95116..95805) FT /transl_table=11 FT /gene="Mb3511c" FT /locus_tag="Mb3511c" FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT /note="Mb3511c, -, len: 229 aa. Equivalent to Rv3481c, len: FT 229 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 229 aa overlap). Probable integral FT membrane protein. No real similarity with others." FT /db_xref="UniProtKB/TrEMBL:Q7TWF0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95697.1" FT /translation="MRGLLPVAGHWVSVLTGLVPLALVIALSPLSVIPAVLVVHSPQPR FT PSSLAFLGGWLLGLAVVTAVFVAASGALGGLSTTSPAWASWLRVVLGSALIVFGVLRWL FT TRHRHTEMPGWMRAFASFTPARAGLVGAVLVVVRPEVLIICAAAGLAIGSGGHGAAGSW FT IYTAFFAMLAASTVAIPILAYVAAGDRLDDSLERLKDWMEKNHAGMVAAILVVIGLLLL FT YNGVHAM" FT CDS complement(95947..96729) FT /transl_table=11 FT /gene="Mb3512c" FT /locus_tag="Mb3512c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb3512c, -, len: 260 aa. Equivalent to Rv3482c, len: FT 260 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 260 aa overlap). Probable conserved FT membrane protein. N-terminal region shares some similarity FT with N-terminus of O88067|SCI35.32c PUTATIVE MEMBRANE FT PROTEIN from Streptomyces coelicolor (319 aa), FASTA FT scores: opt: 155, E(): 0.023, (54.55% identity in 33 aa FT overlap); and with C-terminus of O06254|Rv3437|MTCY77.09 FT HYPOTHETICAL 17.9 KDA PROTEIN from Mycobacterium FT tuberculosis strain H37Rv (alias AAK47883|MT3542.1 from FT strain CDC1551) (158 aa), FASTA scores: opt: 140, E(): FT 0.11, (58.8% identity in 34 aa overlap). Some similarity to FT others e.g. Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN from FT Streptomyces coelicolor (347 aa), FASTA scores: opt: 131, FT E(): 0.75, (29.4% identity in 221 aa overlap). First start FT taken." FT /db_xref="InterPro:IPR018929" FT /db_xref="UniProtKB/TrEMBL:Q7TWE9" FT /protein_id="CAD95698.1" FT /translation="MEHDVATSPPAGWYTDPDGSAGQRYWDGDRWTRHRRPNPSAPRSP FT LALRVDGLRSRWLGMPAGLRLTVPVAAVLTMVGVAVYAWIRPLPDDWSQLPKRLSCQLR FT PGPTPPATITVASVDVSHPRGAVLRLVVRFAEPLPPSPSGSFASGFAGYLLTYTIANNG FT KEFAELGPQQDTDELAIRKPGESRGTEPNMRPDRNTNARRTAPDTVEINLETKRLGLDQ FT APVDPQLTFAAQFRTPSTVTVDFGSQFCQGERLAGQRR" FT CDS complement(96773..97435) FT /transl_table=11 FT /gene="Mb3513c" FT /locus_tag="Mb3513c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3513c, -, len: 220 aa. Equivalent to Rv3483c, len: FT 220 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 220 aa overlap). Conserved hypothetical FT protein, similar to Q9CC94|ML1099 PUTATIVE LIPOPROTEIN from FT Mycobacterium leprae (202 aa), FASTA scores: opt: 276, E(): FT 1.4e-08, (33.1% identity in 148 aa overlap). Also showing FT similarity with Mycobacterium tuberculosis proteins FT Q11065|LPRE_MYCTU|LPRE|Rv1252c|MT1291|MTCY50.30. PUTATIVE FT LIPOPROTEIN PRECURSOR (202 aa), FASTA scores: opt: 276, FT E(): 1.4e-08, (29.5% identity in 200 aa overlap); FT O53445|Rv1097c|MTV017.50c HYPOTHETICAL 29.9 KDA PROTEIN FT (293 aa), FASTA scores: opt: 161, E(): 0.047, (25.4% FT identity in 118 aa overlap); FT P71882|LPPP_MYCTU|Rv2330c|MT2392|MTCY3G12.04 PUTATIVE FT LIPOPROTEIN PRECURSOR (175 aa), FASTA scores: opt: 146, FT E(): 0.21, (28.25% identity in 184 aa overlap); and FT O06170|Rv2507|MTCY07A7.13 HYPOTHETICAL 28.5 KDA PROTEIN FT (273 aa), FASTA scores: opt: 148, E(): 0.23, (25.15% FT identity in 191 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWE8" FT /protein_id="CAD95699.1" FT /translation="MSDEIDPDWPAPAYQPSDDVDTTPPAPGGSWPTAWLVALVVLACV FT AAAVVAYAGMHRVRPGANQAAPATTSAPARPTSPASQVGPCGPDEATAVRAALAQLAPD FT SKTGRPWNSTPEDSNYDPCADLSAVLVTVQDATNSSPDQALMFHRGTFVGTATPRAYPF FT TNLIGPASTNDIVVLSYRTRQSCDGCQDGILTIVGFAWRGDHVQILDSLPELFDAPP" FT CDS 97701..99239 FT /transl_table=11 FT /gene="cpsA" FT /locus_tag="Mb3514" FT /product="POSSIBLE CONSERVED PROTEIN CPSA" FT /note="Mb3514, cpsA, len: 512 aa. Equivalent to Rv3484, FT len: 512 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 512 aa overlap). Possible cpsA, FT hypothetical protein, equivalent to Q50160|CPSA|ML2247 FT HYPOTHETICAL PROTEIN CPSA from Mycobacterium leprae (516 FT aa), FASTA scores: opt: 2557, E(): 1.6e-143, (74.9% FT identity in 518 aa overlap); and with good similarity to FT Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium FT leprae (489 aa), FASTA scores: opt: 855, E(): 4.6e-43, FT (34.45% identity in 502 aa overlap). Also similar (or with FT similarity) to hypothetical proteins from Mycobacterium FT tuberculosis: P96872|Rv3267|MTCY71.07 (498 aa), FASTA FT scores: opt: 928, E(): 2.3e-47, (37.35% identity in 498 aa FT overlap); and O53834|Rv0822c|MTV043.14c (684 aa), FASTA FT scores: opt: 425, E(): 1.5e-17, (26.15% identity in 524 aa FT overlap). Shows also similarity with various bacterial FT proteins e.g. Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL FT PROTEIN from Streptomyces coelicolor (507 aa), FASTA FT scores: opt: 329, E(): 5.3e-12, (28.85% identity in 478 aa FT overlap); Q9K4E6|2SC6G5.02 CONSERVED HYPOTHETICAL PROTEIN, FT POSSIBLE MEMBRANE PROTEIN, from Streptomyces coelicolor FT (382 aa), FASTA scores: opt: 305, E(): 1.1e-10, (29.8% FT identity in 386 aa overlap); O69850|SC1C3.08c PUTATIVE FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (366 FT aa), FASTA scores: opt: 304, E(): 1.2e-10, (29.6% identity FT in 395 aa overlap); Q9KZK3|SCE34.23 PUTATIVE FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (396 FT aa), FASTA scores: opt: 296, E(): 3.8e-10, (31.25% identity FT in 349 aa overlap); AAK43602|CPSA CPSA PROTEIN from FT Streptococcus agalactiae (485 aa), FASTA scores: opt: 250, FT E(): 2.4e-07, (30.25% identity in 162 aa overlap); etc." FT /db_xref="InterPro:IPR004474" FT /db_xref="UniProtKB/TrEMBL:Q7TWE7" FT /protein_id="CAD95700.1" FT /translation="MARSEGNRPRHRAVPQPSRIRKRLSRGVMTLVSVVALLMTGAGYW FT VAHGALGGITISQALTPEDPRSSGNNMNILLIGLDSRKDQEGNDLPWSVLKQLHAGDSD FT DGGYNTNTLILVHVGADGKVVAFSIPRDDWVPFTGVPGYNHIKIKEAYGLTKQYVAEQL FT ANQGVSDRKELETRGREAARAATLRAVRSLTGVPIDYFAEINLAGFYDLAQTLGGVDVC FT LNHAVYDSYSGADFPAGRQRLNAAQALAFVRQRHGLDNGDLDRTHRQQAFLSSVMRELQ FT DSGTFTNLDRLDNLMAVARKDVVLSAGWDEDLFRRMGDLAGGNVEFRTLPVVRYDNIDG FT QDVNIIDPTAIRAEVAAAFGSAPPTSQTAAAAKPNPSTVVDVVNAGSISGLASQVSGAL FT LKRGYTAGQVRDRESGDPFTTAIEYGAGAETDAQNVADLLGIDAPNHPDPAVAPGHIRV FT TVDTNFSLPAPDEATAAATSTETSTYPLYGGGTTTDPTPDQGAPIDGGGVPCVN" FT CDS complement(99245..100189) FT /transl_table=11 FT /gene="Mb3515c" FT /locus_tag="Mb3515c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3515c, -, len: 314 aa. Equivalent to Rv3485c, len: FT 314 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 314 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), similar, but longer FT 41 aa, to P71824|Rv0769|MTCY369.14 PUTATIVE SHORT-CHAIN FT TYPE DEHYDROGENASE/REDUCTASE CY369.14 from Mycobacterium FT tuberculosis (248 aa), FASTA scores: opt: 462, E(): FT 1.8e-19, (34.0% identity in 253 aa overlap). Also similar FT to various dehydrogenases e.g. P25529|HDHA_ECOLI|HSDH|B1619 FT NAD-DEPENDENT 7 ALPHA-HYDROXYSTEROID DEHYDROGENASE (SDR FT FAMILY) (EC 1.1.1.159) from Escherichia coli strain K12 FT (alias BAB35750|ECS2327 or AAG56608|HDHA for strain FT O157:H7) (255 aa), FASTA scores: opt: 462, E(): 1.8e-19, FT (34.7% identity in 248 aa overlap); Q9FD15|RUBG PUTATIVE FT REDUCTASE (SDR FAMILY) from Streptomyces collinus (249 aa), FT FASTA scores: opt: 446, E(): 1.5e-18, (36.1% identity in FT 255 aa overlap); BAB51974|MLL5540 PUTATIVE DEHYDROGENASE FT from Rhizobium loti (Mesorhizobium loti) (253 aa), FASTA FT scores: opt: 442, E(): 2.5e-18, (36.25% identity in 251 aa FT overlap); Q08632|SDR1_PICAB SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE (SDR FAMILY) from Picea abies FT (Norway spruce) (Picea excelsa) (271 aa), FASTA scores: FT opt: 441, E(): 3.1e-18, (32.3% identity in 260 aa overlap); FT Q9A326|CC3380 2-DEOXY-D-GLUCONATE 3-DEHYDROGENASE from FT Caulobacter crescentus (260 aa), FASTA scores: opt: 436, FT E(): 5.7e-18, (32.8% identity in 253 aa overlap); FT Q16698|DECR_HUMAN 2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL FT PRECURSOR (EC 1.3.1.34) from Homo sapiens (Human) (335 aa), FT FASTA scores: opt: 430, E(): 1.5e-17, (30.4% identity in FT 306 aa overlap); etc. Contains short-chain alcohol FT dehydrogenase family signature (PS00061). BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY (SDR)." FT /db_xref="GOA:Q7TWE6" FT /db_xref="HSSP:1DFI" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TWE6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95701.1" FT /translation="MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQD FT RTYLVTGGGSGIGKGVAAGLVAAGAAVMIVGRNPDKLAAAVKDIEALKTGAIGYEPADI FT TDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTMYVL FT KHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSWVRVN FT SIRPGLIRTDLVVPVTESPELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASWITGQV FT INVDGGHMLRRGPDFSPMLEPVFGADGLRGVVG" FT CDS 100395..100844 FT /transl_table=11 FT /gene="Mb3516" FT /locus_tag="Mb3516" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3516, -, len: 149 aa. Equivalent to Rv3486, len: FT 149 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 149 aa overlap). Conserved hypothetical FT protein, similar to Q9RC47|YFID|BH3304 HYPOTHETICAL PROTEIN FT from Bacillus halodurans (129 aa), FASTA scores: opt: 186, FT E(): 2.1e-05, (40.0% identity in 95 aa overlap); and FT Q9KKT1|VCA1019 HYPOTHETICAL PROTEIN from Vibrio cholerae FT (148 aa), FASTA scores: opt: 128, E(): 0.15, (35.25% FT identity in 139 aa overlap). Some similarity to other FT proteins e.g. P54720|YFID_BACSU HYPOTHETICAL PROTEIN from FT Bacillus subtilis (134 aa), FASTA scores: opt: 165, E(): FT 0.00052, (31.75% identity in 126 aa overlap). Equivalent to FT AAK47949 from Mycobacterium tuberculosis strain CDC1551 FT (163 aa) but shorter 14 aa." FT /db_xref="InterPro:IPR011637" FT /db_xref="UniProtKB/TrEMBL:Q7TWE5" FT /protein_id="CAD95702.1" FT /translation="MHAEGPPSVICIRLLVGLVFLSEGIQKFMYPDQLGPGRFERIGIP FT AATFFADLDGVVEIVCGTLVLLGLLTRVAAVPLLIDMVGAIVLTKLRALQPGGFLGVEG FT FWGMAHAARTDLSMLLGLIFLLWSGPGRWSLDRRLSKRATACGAR" FT CDS complement(100797..101630) FT /transl_table=11 FT /gene="lipF" FT /locus_tag="Mb3517c" FT /product="PROBABLE ESTERASE/LIPASE LIPF" FT /EC_number="3.-.-.-" FT /note="Mb3517c, lipF, len: 277 aa. Equivalent to Rv3487c, FT len: 277 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 277 aa overlap). Probable lipF, FT esterase/lipase (EC 3.-.-.-), highly similar, but shorter FT 50 aa, to O53424|LIPU|Rv1076|MTV017.29 PUTATIVE FT ESTERASE/LIPASE from Mycobacterium tuberculosis (297 aa), FT FASTA scores: opt: 1229, E(): 3.3e-71, (76.4% identity in FT 246 aa overlap); and similar to other putative lipases from FT Mycobacterium tuberculosis e.g. FT P71759|LIPK|RV2385|MTCY253.36c (306 aa), FASTA scores: opt: FT 468, E(): 1.2e-22, (36.2% identity in 254 aa overlap). FT Equivalent, but shorter 79 aa, to Q9ZBM4|MLCB1450.08|ML0314 FT PUTATIVE HYDROLASE (PUTATIVE ESTERASE) from Mycobacterium FT leprae (335 aa), FASTA scores: opt: 1225, E(): 6.6e-71, FT (73.6% identity in 250 aa overlap). Also similar to FT esterases and lipases of around 300 aa e.g. Q44087|EST FT ESTERASE PRECURSOR from Acinetobacter lwoffii (303 aa), FT FASTA scores: opt: 428, E(): 4.3e-20, (31.85% identity in FT 251 aa overlap); P18773|EST_ACICA ESTERASE (EC 3.1.1.-) FT from Acinetobacter calcoaceticus (303 aa), FASTA scores: FT opt: 420, E(): 1.4e-19, (31.5% identity in 251 aa overlap); FT Q9KIU1 ESTERASE from uncultured bacterium Plasmid pAH116 FT (308 aa), FASTA scores: opt: 405, E(): 1.3e-18, (35.1% FT identity in 242 aa overlap); Q9X8J4|SCE9.22 PUTATIVE FT ESTERASE from Streptomyces coelicolor (266 aa), FASTA FT scores: opt: 390, E(): 1e-17, (35.85% identity in 237 aa FT overlap); etc. Equivalent to AAK47950 from Mycobacterium FT tuberculosis strain CDC1551 (327 aa) but shorter 50 aa." FT /db_xref="GOA:Q7TWE4" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:Q7TWE4" FT /protein_id="CAD95703.1" FT /translation="MRAPGVRAADGAGRVVLYLHGGAFVMCGPNSHSRIVNALSGFAES FT PVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQIVLAGDSAGGYLALALAQRLQ FT CDDEKPAAIVAISPLLQLAKGPKQDHPNIGTDAMFPARAFDALAAWVRAAAAKNMVDGR FT PEDLYEPLDHIESSLPPTLIHVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQ FT LATPLVPEATRSLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI" FT CDS 102290..102613 FT /transl_table=11 FT /gene="Mb3518" FT /locus_tag="Mb3518" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3518, -, len: 107 aa. Equivalent to Rv3488, len: FT 107 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.1% identity in 107 aa overlap). Hypothetical protein, FT similar to various bacterial proteins e.g. O28730|AF1542 FT CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus FT (101 aa), FASTA scores: opt: 321, E(): 6.4e-15, (50.55% FT identity in 87 aa overlap); O50207 SQ1_IV (FRAGMENT) from FT Rhodococcus erythropolis (59 aa), FASTA scores: opt: 298, FT E(): 1.4e-13, (71.2% identity in 59 aa overlap); FT Q9KFB0|BH0575 BH0575 PROTEIN from Bacillus halodurans (102 FT aa), FASTA scores: opt: 294, E(): 4.1e-13, (43.15% identity FT in 95 aa overlap); etc. Also similar to M. tuberculosis FT P71704|Rv0047c|MTCY21D4.10c (180 aa) (37.8% identity in 82 FT aa overlap)." FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7TWE3" FT /protein_id="CAD95704.1" FT /translation="MREFQRAAVRLHILHHAADNEVHGAWLTQELSRHGYRVSPGTLYP FT TLHRLEADGLLVSEQRVVDGRARRVYRATPAGRAALTEDRRALEELAREVLGRQSHTAG FT NGT" FT CDS 102695..102859 FT /transl_table=11 FT /gene="Mb3519" FT /locus_tag="Mb3519" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3519, -, len: 54 aa. Equivalent to Rv3489, len: 54 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 54 aa overlap). Hypothetical unknown protein. FT No similarity with other proteins." FT /db_xref="UniProtKB/TrEMBL:Q7TWE2" FT /protein_id="CAD95705.1" FT /translation="MSTKSDHGEIGDVEPLADSTASQARRVVAAYANDADECRIFLSML FT GIGPAKLES" FT CDS 102859..104361 FT /transl_table=11 FT /gene="otsA" FT /locus_tag="Mb3520" FT /product="PROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE FT SYNTHASE [UDP-FORMING] OTSA (TREHALOSE-6-PHOSPHATE FT SYNTHASE) (UDP-GLUCOSE-GLUCOSEPHOSPHATE FT GLUCOSYLTRANSFERASE) (TREHALOSEPHOSPHATE-UDP FT GLUCOSYLTRANSFERASE) (TREHALOSE-6-PHOSPHATE SYNTHETASE) FT (TREHALOSE-PHOSPHATE SYNTHASE) (TREHALOSE-PHOSPHATE FT SYNTHETASE) (TRANSGLUCOSYLASE) (TREHALOSEPHOSPHATE-UDP FT GLUCOSYL TRANSFERASE)" FT /EC_number="2.4.1.15" FT /note="Mb3520, otsA, len: 500 aa. Equivalent to Rv3490, FT len: 500 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 500 aa overlap). Probable otsA, alpha, FT alpha-trehalose-phosphate synthase (EC 2.4.1.15) (see FT citations below), equivalent to Q50167|OTSA|ML2254 PROBABLE FT TREHALOSE-PHOSPHATE SYNTHASE from Mycobacterium leprae (498 FT aa), FASTA scores: opt: 2706, E(): 1.6e-166, (80.3% FT identity in 497 aa overlap). Also similar to others e.g. FT Q92410|TPS1_CANAL from Candida albicans (Yeast) (478 aa), FT FASTA scores: opt: 895, E(): 4.9e-50, (37.15% identity in FT 479 aa overlap); FT Q00764|TPS1_YEASTTPS1|CIF1|BYP1|FDP1|GGS1|GLC6|YBR126c|YBR0 FT 922 from Saccharomyces cerevisiae (Baker's yeast) (495 aa), FT FASTA scores: opt: 847, E(): 6.2e-47, (36.1% identity in FT 490 aa overlap); BAB48232|MLL0691 from Rhizobium loti FT (Mesorhizobium loti) (520 aa), FASTA scores: opt: 884, E(): FT 2.7e-49, (36.2% identity in 478 aa overlap); etc. FT Equivalent to AAK47953 from Mycobacterium tuberculosis FT strain CDC1551 (478 aa) but longer 22 aa." FT /db_xref="GOA:Q7TWE1" FT /db_xref="HSSP:1GZ5" FT /db_xref="InterPro:IPR001830" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWE1" FT /protein_id="CAD95706.1" FT /translation="MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWKR FT SPGGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPVRLSTTDI FT AQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEAASRAAAHGATVWVQDY FT QLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIQGLLGADLVGFHLPGGA FT QNFLILSRRLVGTDTSRGTVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAARDRNI FT RRRAREIRTELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATP FT SRERVESYQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVMLVT FT PLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALN FT QTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGAHPRGQG" FT CDS 104513..105091 FT /transl_table=11 FT /gene="Mb3521" FT /locus_tag="Mb3521" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3521, -, len: 192 aa. Equivalent to Rv3491, len: FT 192 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 192 aa overlap). Hypothetical unknown FT protein. No significant homology with other proteins." FT /db_xref="UniProtKB/TrEMBL:Q7TWE0" FT /protein_id="CAD95707.1" FT /translation="MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQA FT GVSGVTWTITALCDQPSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFSGR FT ARMSSMLWTFQVNQADGVACPDGSTAPSSETYAFSDETLTGTHTTVHGAVCGLQPKLSK FT QPFSLQLIGPPPSPVQRYPLYCNNIAMCY" FT CDS complement(105088..105570) FT /transl_table=11 FT /gene="Mb3522c" FT /locus_tag="Mb3522c" FT /product="CONSERVED HYPOTHETICAL MCE ASSOCIATED PROTEIN" FT /note="Mb3522c, -, len: 160 aa. Equivalent to Rv3492c, len: FT 160 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 160 aa overlap). Conserved hypothetical FT Mce-associated protein, showing some similarity to FT hypothetical Mycobacterium tuberculosis proteins e.g. FT O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA FT scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa FT overlap); and FT Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa), FT FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 FT aa overlap). Contains lipocalin signature at C-terminus FT (PS00213)." FT /db_xref="InterPro:IPR002345" FT /db_xref="UniProtKB/TrEMBL:Q7TWD9" FT /protein_id="CAD95708.1" FT /translation="MRRLISVAYALMVATIVGLSAAGGWFYWDRVQTGGEASARALLPK FT LAMQEIPQVFGYDYQTVERSLTAVYPLLTPDYRQEFQKSANAQIIPEAKKREVVVQANV FT VGVGVMDAKRDCASVMVYLNRTVTDKTRQPLYDGSRLRVDFQRIDGKWLIAYITPI" FT CDS complement(105570..106298) FT /transl_table=11 FT /gene="Mb3523c" FT /locus_tag="Mb3523c" FT /product="CONSERVED HYPOTHETICAL MCE ASSOCIATED ALANINE AND FT VALINE RICH PROTEIN" FT /note="Mb3523c, -, len: 242 aa. Equivalent to Rv3493c, len: FT 242 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 242 aa overlap). Conserved hypothetical FT Mce-associated ala-, val-rich protein, showing weak FT similarity to O07422|Z97050|Rv0178|MTCI28.18 HYPOTHETICAL FT 25.9 KDA PROTEIN (near Mce operon1) from Mycobacterium FT tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, FT (24.65% identity in 211 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWD8" FT /protein_id="CAD95709.1" FT /translation="MAADTGVAGGQQSTTRRARRKASRPAGPAEGESSRPAQGAATVRA FT AARTESKPAKAAKPALRPVKPPPRRPAHRVLVGWLSLAAGLLAIAALAWGVTALVMQNR FT DADARQARNQRFVDAATQTVVNMFSYTPDTIDESVNRFVNGTSGPLRGMLNANNNVDNL FT KGLFRATNATSEAVVNGAALEGIDEISDNASVLVSVRVTVADIDGVNKPSMPYRLRVIV FT HEDENGRMTGYDLKYPDGGN" FT CDS complement(106298..107992) FT /transl_table=11 FT /gene="mce4F" FT /locus_tag="Mb3524c" FT /product="MCE-FAMILY PROTEIN MCE4F" FT /note="Mb3524c, mce4F, len: 564 aa. Equivalent to Rv3494c, FT len: 564 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 564 aa overlap). mce4F; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), similar to FT Mycobacterium tuberculosis proteins FT O07418|Rv0174|MTCI28.14|mce1F (515 aa); FT O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); and FT O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to FT others e.g. Q9CD09|MCE1F|ML2594 PUTATIVE SECRETED PROTEIN FT from Mycobacterium leprae (516 aa), FASTA scores: opt: FT 1040, E(): 3.6e-31, (35.9% identity in 529 aa overlap); FT Q9F361|SC8A2.02c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (433 aa), FASTA scores: opt: 570, FT E(): 3.7e-14, (30.8% identity in 458 aa overlap); etc. Has FT hydrophobic stretch, possibly a signal peptide at the FT N-terminus." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:Q7TWD7" FT /protein_id="CAD95710.1" FT /translation="MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSAD FT FVAGGGLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRSVSAI FT GEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETLLGSLGDTRLRELLH FT EAFIATNGAGPELARLIESARLLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLA FT DGLARFTWQLRAADPRLRDTLAGAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIY FT HKSIEQLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLVRSPA FT DESVREIPRDMYCKTAQNDPSTVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTNPW FT RGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDPGVPIVGPPPPGQVAGPGPAPHQPAQ FT PAPPPNDNGPPPPFTSWMPPGYPPEPPQVPYPATIPPPPPPEGTGPPPGPAPGPQPQAS FT GPAYTIYDQLSGAFADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL" FT CDS complement(108003..109157) FT /transl_table=11 FT /gene="lprN" FT /locus_tag="Mb3525c" FT /standard_name="mce4E" FT /product="POSSIBLE MCE-FAMILY LIPOPROTEIN LPRN (MCE-FAMILY FT LIPOPROTEIN MCE4E)" FT /note="Mb3525c, lprN, len: 384 aa. Equivalent to Rv3495c, FT len: 384 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 384 aa overlap). Possible lprN FT (alternate gene name: mce4E), lipoprotein which belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); FT O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); and FT O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa). Also similar FT to others e.g. Q9F360|SC8A2.03c PUTATIVE SECRETED PROTEIN FT from Streptomyces coelicolor (413 aa), FASTA scores: opt: FT 656, E(): 2.2e-32, (37.55% identity in 317 aa overlap); FT Q9CD10|LPRK|ML2593 PUTATIVE LIPOPROTEIN from Mycobacterium FT leprae (392 aa), FASTA scores: opt: 616, E(): 5.5e-30, FT (28.95% identity in 373 aa overlap); etc. Contains possible FT signal sequence and appropriately positioned PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:Q7TWD6" FT /protein_id="CAD95711.1" FT /translation="MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHGEGAYSVT FT VEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVKLDLDKNVLLPANAVAK FT VSQTSLLGSLHVELAPPTDRPPTGRLVDGSRITEANTDRFPTTEEVFSALGVVVNKGNV FT GALEEIIDETHQAVAGRQAQFVNLVPRLAELTAGLNRQVHDIIDALDGLNRVSAILARD FT KDNLGRALDTLPDAVRVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYS FT IVKALNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFFTTA FT YFDPNMAHMDEILNPPDFLIGELANLSGQAADPFKIPPGTASGQ" FT CDS complement(109154..110509) FT /transl_table=11 FT /gene="mce4D" FT /locus_tag="Mb3526c" FT /product="MCE-FAMILY PROTEIN MCE4D" FT /note="Mb3526c, mce4D, len: 451 aa. Equivalent to Rv3496c, FT len: 451 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 451 aa overlap). mce4D; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT O07416|Rv0172|MTCI28.12|mce1D (530 aa); FT O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and FT O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to FT others e.g. Q9CD11|MCE1D|ML2592 PUTATIVE SECRETED PROTEIN FT from Mycobacterium leprae (531 aa), FASTA scores: opt: 837, FT E(): 2.6e-34, (34.55% identity in 446 aa overlap); FT Q9F359|SC8A2.04c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (337 aa), FASTA scores: opt: 606, FT E(): 4.9e-23, (32.35% identity in 300 aa overlap); etc. FT Hydrophobic region at N-terminus." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:Q7TWD5" FT /protein_id="CAD95712.1" FT /translation="MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNKRTIVGY FT FTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVDVQAVIMSPNLV FT AARFIQLTPVYTGGAVLPDNGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQGPL FT GAAINQAADTLDGNGDSLHNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQ FT IVQFAGHVASVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ FT TLSDQSENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGSFDTAA FT GPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKGQIIYDTPATEAKSE FT TPVPELTWVPAGGGAPVGNPADLQSLLVPPAPGPAPAPPAPGAGPGEHGGGG" FT CDS complement(110506..111579) FT /transl_table=11 FT /gene="mce4C" FT /locus_tag="Mb3527c" FT /product="MCE-FAMILY PROTEIN MCE4C" FT /note="Mb3527c, mce4C, len: 357 aa. Equivalent to Rv3497c, FT len: 357 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 357 aa overlap). mce4C; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT O07415|R0171|MTCI28.11|mce1C (515 aa); FT O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); and FT O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to FT others e.g. Q9F358|SC8A2.05c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (351 aa), FASTA scores: opt: 658, FT E(): 1.1e-30, (33.95% identity in 318 aa overlap); FT Q9CD12|MCE1C|ML2591 PUTATIVE SECRETED PROTEIN from FT Mycobacterium leprae (519 aa), FASTA scores: opt: 555, E(): FT 1.2e-24, (28.35% identity in 328 aa overlap); etc. FT Hydrophobic region at N-terminus." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:Q7TWD4" FT /protein_id="CAD95713.1" FT /translation="MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGK FT TYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSLAAIR FT TDTILGERSIAVSPAGSGKSTTIPLSRTTTPYTLNGVLQDLGRNANDLNRPQFEQALNV FT FTQALHDATPQVRGAVDGLTSLSRALNRRDEALQGLLAHAKSVTSVLSERAEQVNKLVE FT DGNQLFAALDARRAALSALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERR FT DYITEALKRLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPGKLPDSLAD FT YLRGFIQERWIIRPKSP" FT CDS complement(111569..112621) FT /transl_table=11 FT /gene="mce4B" FT /locus_tag="Mb3528c" FT /product="MCE-FAMILY PROTEIN MCE4B" FT /note="Mb3528c, mce4B, len: 350 aa. Equivalent to Rv3498c, FT len: 350 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 350 aa overlap). mce4B; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT O07414|Rv0170|MTCI28.10|mce1B (346 aa); FT O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); and FT O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to FT others e.g. Q9CD13|MCE1B|ML2590 PUTATIVE SECRETED PROTEIN FT from Mycobacterium leprae (346 aa), FASTA scores: opt: 803, FT E(): 6.1e-41, (41.05% identity in 346 aa overlap); FT Q9F357|SC8A2.06c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (354 aa), FASTA scores: opt: 624, FT E(): 3.4e-30, (32.55% identity in 338 aa overlap); etc. FT Hydrophobic region at N-terminus." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:Q7TWD3" FT /protein_id="CAD95714.1" FT /translation="MAGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTVY FT HATFTDASRLKAGQKVRIAGVPVGSVKAVKLNPDHSIDVAFAIDRSYTLYSSTRAVIRY FT ENLVGDRFLEITSGPGELRKLPPGGTINVAHTQPALDLDALLGGLRPVLKGFDADKINT FT ITSAVIELLQGQGGPLANVLADTGAFSAALGARDQLIGEVITNLNAVLATVDAKSAQFS FT ASVDQLQQLVSGLAKNRDPIAGAISPLASTTTDLTELLRNSRRPLQGILENARPLATEL FT DNRKAEVNNDIEQLGEDYLRLSALGSYGAFFNIYFCSVTIKINGPAGSDILLPIGGQPD FT PSKGRCAFAK" FT CDS complement(112621..113823) FT /transl_table=11 FT /gene="mce4A" FT /locus_tag="Mb3529c" FT /standard_name="mce4" FT /product="MCE-FAMILY PROTEIN MCE4A" FT /note="Mb3529c, mce4A, len: 400 aa. Equivalent to Rv3499c, FT len: 400 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 400 aa overlap). mce4A; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); FT O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and FT O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar FT to others e.g. Q9F356|SC8A2.07c PUTATIVE SECRETED PROTEIN FT from Streptomyces coelicolor (418 aa), FASTA scores: opt: FT 619, E(): 7.8e-30, (32.4% identity in 352 aa overlap); FT Q9S4U5|MCE1 MYCOBACTERIAL CELL ENTRY PROTEIN from FT Mycobacterium bovis BCG (454 aa), FASTA scores: opt: 529, FT E(): 2.1e-24, (30.35% identity in 448 aa overlap); FT Q9CD14|MCE1A|ML2589 from Mycobacterium leprae (441 aa), FT FASTA scores: opt: 515, E(): 1.4e-23, (28.35% identity in FT 430 aa overlap); etc. Contains a possible N-terminal signal FT sequence. Note that previously known as mce4." FT /db_xref="InterPro:IPR003399" FT /db_xref="UniProtKB/TrEMBL:Q7TWD2" FT /protein_id="CAD95715.1" FT /translation="MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTV FT SSPRAGLVMEKGAKVKYRGIQVGKVTDISYSGNQARLKLAIDSGEMGFIPSNATVRIAG FT NTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNAT FT LSALSEGLRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDLNT FT VFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTS FT DYSPVFGCLFKGIARGVKEFAPLIGVRKAGLFTSSSFVLGAPSYTYPESLPIVNASGGP FT NCRGLPDIPTKQTGGSFYRAPFLVTDNALIPYQPFTELQVDAPSTLQFLFNGAFAERDD FT F" FT CDS complement(113843..114685) FT /transl_table=11 FT /gene="yrbE4B" FT /locus_tag="Mb3530c" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE4B" FT /note="Mb3530c, yrbE4B, len: 280 aa. Equivalent to Rv3500c, FT len: 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 280 aa overlap). yrbE4B, hypothetical FT unknown integral membrane protein, part of mce4 operon and FT member of YrbE family (see citations below for more FT information), highly similar to Mycobacterium tuberculosis FT proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); FT O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and FT O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly FT similar to conserved hypothetical integral membrane FT proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. FT Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa), FT FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity in FT 269 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus FT influenzae (261 aa), FASTA scores: opt: 270, E(): 6e-11, FT (25.4% identity in 264 aa overlap); etc." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:Q7TWD1" FT /protein_id="CAD95716.1" FT /translation="MSYDVTIRFRRFFSRLQRPVDNFGEQALFYGETMRYVPNAITRYR FT KETVRLVAEMTLGAGALVMIGGTVGVAAFLTLASGGVIAVQGYSSLGDIGIEALTGFLS FT AFLNVRVVAPVIAGIALAATIGAGATAQLGAMRVSEEIDAVECMAVHSVSYLVSTRLIA FT GLVAIIPLYSLSVLAAFFAARFTTVFVNGQSAGLYDHYFNTFLIPSDLLWSFMQAIAMS FT IAVMLVHTYYGYNASGGSVGVGVAVGQAVRTSLIVVVVITLFISLAVYGASGNFNLSG" FT CDS complement(114720..115484) FT /transl_table=11 FT /gene="yrbE4A" FT /locus_tag="Mb3531c" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE4A" FT /note="Mb3531c, yrbE4A, len: 254 aa. Equivalent to Rv3501c, FT len: 254 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 254 aa overlap). yrbE4A, hypothetical FT unknown integral membrane protein, part of mce4 operon and FT member of YrbE family (see citations below for more FT information), highly similar to Mycobacterium tuberculosis FT proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); FT O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and FT O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly FT similar to conserved hypothetical integral membrane FT proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. FT Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa), FT FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity in FT 247 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus FT influenzae (261 aa), FASTA scores: opt: 313, E(): 3e-14, FT (25.7% identity in 241 aa overlap); etc." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:Q7TWD0" FT /protein_id="CAD95717.1" FT /translation="MIQQLAVPARAVGGFFEMSMDTARAAFRRPFQFREFLDQTWMVAR FT VSLVPTLLVSIPFTVLVAFTLNILLREIGAADLSGAGTAFGTITQLGPVVTVLVVAGAG FT ATAICADLGARTIREEIDAMRVLGIDPIQRLVVPRVLASTLVALLLNGLVCAIGLSGGY FT AFSVFLQGVNPGAFINGLTVLTGLRELILAEIKALLFGVMAGLVGCYRGLTVKGGPKGV FT GNAVNETVVYAFICLFVINVVMTAIGVRISAQ" FT CDS complement(115710..116663) FT /transl_table=11 FT /gene="Mb3532c" FT /locus_tag="Mb3532c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3532c, -, len: 317 aa. Equivalent to Rv3502c, len: FT 317 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 317 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), similar to FT Mycobacterium tuberculosis proteins FT P71853|Rv3548c|MTCY03C7.08 HYPOTHETICAL 31.1 KDA PROTEIN FT (304 aa), FASTA scores: opt: 739, E(): 6.2e-35, (45.15% FT identity in 310 aa overlap); and FT Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE FT OXIDOREDUCTASE (247 aa), FASTA scores: opt: 475, E(): FT 5.1e-20, (40.15% identity in 254 aa overlap). Also similar FT to various dehydrogenases e.g. Q9I4V1|PA1023 PROBABLE FT SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (305 FT aa), FASTA scores: opt: 535, E(): 2.3e-23, (37.1% identity FT in 302 aa overlap); Q9UVH9|FOX2 FOX2 PROTEIN (SDR FAMILY) FT (1015 aa), FASTA scores: opt: 487, E(): 3.2e-20, (38.4% FT identity in 276 aa overlap); P22414|FOX2_CANTR PEROXISOMAL FT HYDRATASE-DEHYDROGENASE, D-3-HYDROXYACYL CoA DEHYDROGENASE FT (EC 1.1.1.-) (SDR FAMILY) from Candida tropicalis (Yeast) FT (906 aa) FASTA scores: opt: 481, E(): 6.4e-20, (38.0% FT identity in 250 aa overlap); FT P50171|DHB8_MOUSE|HSD17B8|HKE6|H2-KE6 ESTRADIOL 17 FT BETA-DEHYDROGENASE 8 from Mus musculus (Mouse) (260 aa) FT FASTA scores: opt: 459, E(): 4.3e-19, (39.75% identity in FT 259 aa overlap); CAC41362|BKR1 3-OXYACYL-[ACYL-CARRIER FT PROTEIN] REDUCTASE (EC 1.1.1.100) (FRAGMENT) from Brassica FT napus (Rape) (317 aa), FASTA scores: opt: 447, E(): FT 2.4e-18, (39.2% identity in 255 aa overlap); etc. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Start uncertain." FT /db_xref="GOA:Q7TWC9" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TWC9" FT /protein_id="CAD95718.1" FT /translation="MKLTESNRSPRTTNTTDLSGKVAVVTGAAAGLGRAEALGLARLGA FT TVVVNDVASALDASDVVDEIGAAAADAGAKAVAVAGDISQRATADELLASAVGLGGLDI FT VVNNAGITRDRMLFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRDKAKDAEGGSVFGRL FT VNTSSEAGLVGPVGQANYAAAKAGITALTLSAARALGRYGVCANVICPRARTAMTADVF FT GAAPDVEAGQIDPLSPQHVVSLVQFLASPAAAEVNGQVFIVYGPQVTLVSPPHMERRFS FT ADGTSWDPTELTATLRDYFAGRDPEQSFSATDLMRQ" FT CDS complement(116688..116879) FT /transl_table=11 FT /gene="fdxD" FT /locus_tag="Mb3533c" FT /product="PROBABLE FERREDOXIN FDXD" FT /note="Mb3533c, fdxD, len: 63 aa. Equivalent to Rv3503c, FT len: 63 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 63 aa overlap). Probable fdxD, FT ferredoxin, equivalent to Q9R6Z5|B229_C3_226 HYPOTHETICAL FT 9.3 KDA PROTEIN from Mycobacterium leprae (83 aa) FASTA FT scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa FT overlap). Also similar to several e.g. Q9R6Z5|PHDC from FT Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: FT 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); FT Q9X4X8|DITA3 DIOXYGENASE DITA FERREDOXIN COMPONENT from FT Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166, FT E(): 1.4e-05, (36.2% identity in 58 aa overlap); FT P00203|FER_MOOTH from Moorella thermoacetica (Clostridium FT thermoaceticum) (63 aa), FASTA scores: opt: 157, E(): FT 5.4e-05, (36.65% identity in 60 aa overlap); FT P18325|FER2_STRGO|SUBB from Streptomyces griseolus (64 aa) FT FASTA scores: opt: 157, E(): 5.5e-05, (39.35% identity in FT 61 aa overlap); etc. BELONGS TO THE BACTERIAL TYPE FT FERREDOXIN FAMILY." FT /db_xref="GOA:Q7TWC8" FT /db_xref="InterPro:IPR001080" FT /db_xref="UniProtKB/TrEMBL:Q7TWC8" FT /protein_id="CAD95719.1" FT /translation="MRVIVDRDRCEGNAVCLGIAPDIFDLDDEDYAVVKTDPIPVDQED FT LAEQAIAECPRAALSRGE" FT CDS 117094..118296 FT /transl_table=11 FT /gene="fadE26" FT /locus_tag="Mb3534" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE26" FT /EC_number="1.3.99.-" FT /note="Mb3534, fadE26, len: 400 aa. Equivalent to Rv3504, FT len: 400 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 400 aa overlap). Probable fadE26, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other FT ACYL-COA DEHYDROGENASES from Mycobacterium tuberculosis FT e.g. P71858|FADE29|Rv3543c|MTCY03C7.13 (387 aa) FASTA FT scores: opt: 1031, E(): 7.5e-59, (46.25% identity in 402 aa FT overlap); and P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FT FASTA scores: opt: 617, E(): 3.1e-32, (32.6% identity in FT 423 aa overlap); etc. Also similar to others e.g. FT Q9A6G3|CC2131 from Caulobacter crescentus (403 aa) FASTA FT scores: opt: 710, E(): 3.2e-38, (33.4% identity in 413 aa FT overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 FT aa), FASTA scores: opt: 522, E(): 3.7e-26, (34.1% identity FT in 358 aa overlap); Q9RJX2|SCF37.29c from Streptomyces FT coelicolor (393 aa), FASTA scores: opt: 509, E(): 2.6e-25, FT (34.45% identity in 363 aa overlap); etc. COULD BELONG TO FT THE ACYL-COA DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q7TWC7" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TWC7" FT /protein_id="CAD95720.1" FT /translation="MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNVY FT RETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFLTINSVAPTIMA FT YGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSL FT IQYADYVWLAVRTNPESSGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSATYYSDV FT RVPVANRVGEENAGWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGGTRLID FT SEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGTELATEAYRL FT LMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGMVALGLPRAN FT R" FT CDS 118321..119442 FT /transl_table=11 FT /gene="fadE27" FT /locus_tag="Mb3535" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE27" FT /EC_number="1.3.99.-" FT /note="Mb3535, fadE27, len: 373 aa. Equivalent to Rv3505, FT len: 373 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 373 aa overlap). Probable fadE27, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other FT ACYL-COA DEHYDROGENASES from Mycobacterium tuberculosis FT e.g. P71857|FADE28|Rv3544c|MTCY03C7.12 (339 aa) FASTA FT scores: opt: 497, E(): 1.8e-22, (30.3% identity in 343 aa FT overlap); and P95281|FADE18|Rv1933c|MTCY09F9.31 (363 aa) FT FASTA scores: opt: 421, E(): 6.4e-18, (32.35% identity in FT 334 aa overlap). Also similar to other e.g. Q9A5G8|CC2479 FT from Caulobacter crescentus (344 aa), FASTA scores: opt: FT 425, E(): 3.5e-18, (30.75% identity in 351 aa overlap); FT Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa) FT FASTA scores: opt: 317, E(): 1e-11, (32.8% identity in 372 FT aa overlap); Q9L8Q3|PDTORFO from Pseudomonas stutzeri FT (Pseudomonas perfectomarina) (513 aa), FASTA scores: opt: FT 301, E(): 1.2e-10, (25.9% identity in 394 aa overlap); etc. FT COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q7TWC6" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TWC6" FT /protein_id="CAD95721.1" FT /translation="MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELWR FT KLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLAAGALARFGSP FT ELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGTGHGYRLTGTRTQVGYGPVADAFLV FT PAETDSGAAVFLVAAGDPGVAVTALATTGLGSVGHLELNGAKVDAARRVGGTDVVVWLG FT TLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLT FT LTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDTDHPV FT HRYFLAAKQTEFALGGATGQLRRIGRELAETPA" FT CDS 119513..121021 FT /transl_table=11 FT /gene="fadD17" FT /locus_tag="Mb3536" FT /product="POSSIBLE FATTY-ACID-COA SYNTHETASE FADD17 FT (FATTY-ACID-COA SYNTHASE) (FATTY-ACID-COA LIGASE)" FT /EC_number="6.2.1.-" FT /note="Mb3536, fadD17, len: 502 aa. Equivalent to Rv3506, FT len: 502 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 502 aa overlap). Possible fadD17, FT fatty-acid-CoA synthetase (ligase) (EC 6.2.1.-), similar to FT P72007|FADD1|RV1750c|MTCY28.13c|MTCY04C12.34 from FT Mycobacterium tuberculosis (532 aa), FASTA scores: opt: FT 666, E(): 9.8e-32, (52.05% identity in 488 aa overlap). FT Also similar to various ligases/synthetases e.g. Q9EY88|FCS FT FERULOYL-COA SYNTHETASE from Amycolatopsis sp. HR167 (491 FT aa), FASTA scores: opt: 490, E(): 2.1e-21, (30.3% identity FT in 462 aa overlap); BAB33463|ECS0040 (alias AAG54340|CAIC) FT PROBABLE CROTONOBETAINE/CARNITINE-COA LIGASE from FT Escherichia coli strain O157:H7 (522 aa), FASTA scores: FT opt: 478, E(): 1.1e-20, (28.5% identity in 347 aa overlap); FT Q9KHL1|ENCH PUTATIVE ACYL-COA LIGASE from Streptomyces FT maritimus (535 aa), FASTA scores: opt: 477, E(): 1.3e-20, FT (28.7% identity in 453 aa overlap); Q50017|XCLC|ML1051 FT ACYL-COA SYNTHASE from Mycobacterium leprae (476 aa), FASTA FT scores: opt: 472, E(): 2.3e-20, (31.35% identity in 469 aa FT overlap); P31552|CAIC_ECOLI|B0037 from Escherichia coli FT strain K12 (522 aa), FASTA scores: opt: 467, E(): 4.8e-20, FT (28.75% identity in 348 aa overlap); Q9KBC2|BH2006 from FT Bacillus halodurans LONG-CHAIN ACYL-COA SYNTHETASE (LIGASE) FT (513 aa), FASTA scores: opt: 462, E(): 9.4e-20, (27.65% FT identity in 463 aa overlap); etc. Contains PS00455 Putative FT AMP-binding domain signature." FT /db_xref="GOA:Q7TWC5" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TWC5" FT /protein_id="CAD95722.1" FT /translation="MTPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAA FT LRERLDPARPPHVGVLLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKADCQ FT LVLTGSGSAEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGTSGD FT PKAVKCSHRKVAIAGVTITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALR FT RKFSASQFLADVRRYGATYANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPGDIDR FT FGRRFGCVVMDGFGSTEGGVAITRTLDTPAGALGPLPGGIQIVDPDTGEPCPTGVVGEL FT VNTAGPGGFEGYYNDEAAEAERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWMRVDGENL FT GTAPIERVLMRYPDATEVAVYPVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDL FT GHKQWPSYVRVSAGLPRTMTFKVIKRQLSAEGVACADPVWPIRR" FT CDS 121192..125274 FT /transl_table=11 FT /gene="PE_PGRS53" FT /locus_tag="Mb3537" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb3537, PE_PGRS53, len: 1360 aa. Similar to Rv3507, FT len: 1381 aa, from Mycobacterium tuberculosis strain H37Rv, FT (93.635% identity in 1414 aa overlap). Member of the FT Mycobacterium tuberculosis PE protein family, PGRS FT subfamily of gly-rich proteins, similar to others from M. FT tuberculosis strains H37Rv and CDC1551 e.g. FT O06810|Rv1450c|MTCY493.04 (1329 aa), FASTA scores: opt: FT 2173, E(): 1.4e-135, (51.15% identity in 1412 aa overlap). FT Equivalent to AAK47970 from Mycobacterium tuberculosis FT strain CDC1551 (1384 aa) but with some minor differences FT between the proteins. Contains two PS00583 pfkB family of FT carbohydrate kinases signatures 1. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT insertions of 18 bp, 72 bp and 9 bp (*-cggcggcac), and FT deletions of 90 bp, 54 bp and 18 bp, leads to a shorter FT product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (1360 aa versus 1381 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TWC4" FT /protein_id="CAD95723.1" FT /translation="MSFVLVSPETVAAVATDLKRIGASLAHENASAAASTTAVVSAAAD FT EVSTAVAALFSQHAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFAEAANASPLQSAMGA FT VSASAQTLLSRPLIGNGANATTPGGNGGDGGWLFGSGGNGAPGAAGQSGGNGGSAGLWG FT NGGAGGAGGSGGAAGGNGGNGGWLFGAGGTGGIGGTGAPGAMGGTGGNGGNGALLIGGG FT GLGGAGGMGGTGGGTGGTGGNGGNGALLIGAGGVGGAGGIGGQGTGAGGAAGAGGTGGN FT GGAGGLFMNGGDGGAGGQGGDGAAGDAAASAGGTGGKGGQGGDGGTGGAGGAGPVLFGH FT GGAGGMGGQGGTGGMGGAGGDGTTVIAAGTGGEGGTGGTGGTGGNGADAAAVVGFGANG FT DPGFAGGKGGNGGIGGAAVTGGVAGDGGTGGKGGTGGAGGAGNDAGSTGNPGGKGGDGG FT IGGAGGAGGAAGTGNGGHAGNTGDGGDGGTGGNGGNGTGGVNGADNTLNPDTPGGAGEP FT GGAGGAGGAGGAAGGPGGTGGTGGNGGNAGNNSTNAPVGGEGGAGGDGGAGGAGGAANG FT GTAGSQGTGGVGGDGGAGGNGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVGGAAGAN FT GGTGGSGGNGGDGGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGGNAGGA FT GGNGGAGGQGGNAGQGGAGGAGGNAVIPGDGVGKAPHGGAGGSGGDGGKGGQGGSGGTG FT GSGAPIGGGAGGTGGSGGHAGKGGAGGIGAQGTTITVPGNGGNAGDGGNGGGGGAGGTG FT GDGATGTPAGNGGNGGNAGDGGNGGSGDFGGNTTSGASGSGGNGGNAGTAGSGGAGGTG FT GTGLSGGNGGNGGDGGNGAHGTVGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAGAP FT GPTTGGNAGSQGIGGDGGNGGDGGKGGDGADAVNVVFMPTEPQAATGTAGSAGDPTGGN FT GGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTGSTNANDGTATGGKGGEGGVGSILGG FT PGGNGGTGGNASATGTNGVANAGNGGKGGDGGQFGAGGNGGAGGSVTDGSAGSTAGNGG FT NGGNATNGTIAGQPAGGNGSAGGKGGDGGNIAAGATGTAGNGGNGGNGNDGAVNAGTGG FT SGGNGGNAGGGGANGGDGGAGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNGGN FT GGTGGVGSVGAAGGDGGNGGTGGFAGFGGTAGNGGSGGTGGAGGDGGTGGGGGNGGTGV FT IAGGGGTGGNGGASGAGGAGGTGGFAGNGNAGGNGGTGGASEDGDNGNAGSGATGGTGG FT NGGTGGDGGAAGLGGVA" FT CDS 125565..129947 FT /transl_table=11 FT /gene="PE_PGRS54" FT /locus_tag="Mb3538" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb3538, PE_PGRS54, len: 1460 aa. Similar to Rv3508, FT len: 1901 aa, from Mycobacterium tuberculosis strain H37Rv, FT (71.06% identity in 1904 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, similar to others from Mycobacterium FT tuberculosis strains H37Rv and CDC1551 e.g. downstream FT O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 6598, FT E(): 0, (71.05% identity in 1533 aa overlap). Equivalent to FT AAK47971 from Mycobacterium tuberculosis strain CDC1551 FT (1384 aa) but shorter 13 aa and with some minor differences FT between the proteins. Contains five PS00583 pfkB family of FT carbohydrate kinases signatures 1. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT insertions of 9 bp (*-cggcgcggg), 27 bp and 18 bp, FT deletions of 168 bp, 603 bp and 48 bp, and several FT substitutions lead to a shorter product compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv (1460 aa FT versus 1901 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TWC3" FT /protein_id="CAD95724.1" FT /translation="MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGAD FT EVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAAAAEQIVLGVIN FT APTQALLGRPLIGDGANATTPGGAGGAGGLLFGNGGAGAAGAPGQAGGPGGPAGLWGNG FT GPGGAGGSGGGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVGG FT AGGGTGGAGGRAELLFGAGGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGAGG FT AGGQGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGGTGG FT AGGDGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSAGGAAGAVGVGGTGGQGGAGGM FT GGSGADNASGIGADGGAGGTGGNAGAGGAGGAAGTGGTGGVVGAAGKAGIGGTGGQGGA FT GGAGSAGTDATATGATGGTGFSGGAGGAGGAGGNTGVGGTNGSGGQGGTGGAGGAGGAG FT GVGADNPTGIGGAGGTGGAGGTGGTGGAAGAGGAGGAVGTGGTGGVVGDVGNAGIGGTG FT GKGGAGGTGFAGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQGGAGGAGGAGADNPTGIG FT GAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSVGNAGIGGTGGTGGVGGAGGAGAAAAA FT GSSATGGAGFAGGAGGEGGAGGNSGVGGTNGSGGAGGAGGKGGTGGAGGSGADNPTGAG FT FAGGAGGTGGAAGAGGAGGATGTGGTGGVVGATGSAGIGGAGGRGGDGGDGASGLGLGL FT SGFDGGQGGQGGDGGSAGAGGINGAGGAGGDGGDGGDGATGAAGLGDNGGVGGDGGAGG FT AAGNGGNAGVGLTAKAGDGGAAGNGGNGGAGGAGGAGDNNFNGGQGGAGGQGGQGGLGG FT ASTTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGGDGGDAGAGGGGGFGGAAGK FT AGGGGNGGVGGDGGEGATGLGLDLSGFAGGQGGQGGAGGNAGAGGINGAGGTGGTGGAG FT GDGAPATLIGGPDGGDGGQGGIGGDGGNAGFGAGVPGDGGIGGTGGAGGAGGAGGAGDA FT GADGDPSIDGGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGDGDGFI FT GGSGGTGGTGGDAGAGGLANTGGTAGNAGIGGAGGRGGDGGAGDSGALSQDGNGFAGGQ FT GGQGGAGGNAGAGGINGAGGTGGTGGAGGDGAPATLIGGPDGGDGGQGGGAGFGSGVAG FT AAGAGGNGGKGGDGGTGGTGGTNFAGGQGGAGGRGGAGGNGANGVGDNAAGGDGGNGGA FT GGLGGGGGTGGTNGNGGLGGGGGNGGAGGAGGTPTGSGTEGTGGDGGDAGAGGNGGSAT FT GVGNGGNGGDGGNGGDGGNGAPGGFGGGAGAGGLGGSGAGGGTDGDDGNGGSPGTDGS" FT CDS complement(130114..131661) FT /transl_table=11 FT /gene="ilvX" FT /locus_tag="Mb3539c" FT /product="PROBABLE ACETOHYDROXYACID SYNTHASE ILVX FT (ACETOLACTATE SYNTHASE)" FT /EC_number="2.2.1.6" FT /note="Mb3539c, ilvX, len: 515 aa. Equivalent to Rv3509c, FT len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 515 aa overlap). Probable ilvX, FT acetohydroxyacid synthase (EC 4.1.3.18), equivalent to FT Mycobacterium leprae protein described as Acetolactate FT synthase I, valine sensitive, large subunit (EC 4.1.3.18) FT Q49865|ILVX|ILVI1|B229_C3_222 (515 aa), FASTA scores: opt: FT 2762, E(): 8.8e-145, (82.9% identity in 515 aa overlap). FT Also similar to various enzymes (principally FT acetohydroxyacid/acetolactate synthases) e.g. Q9AB41|CC0393 FT THIAMINE-PYROPHOSPHATE-REQUIRING ENZYME from Caulobacter FT crescentus (512 aa), FASTA scores: opt: 1572, E(): 2.8e-79, FT (50.95% identity in 514 aa overlap); BAB50432|MLL3567 FT ACETOLACTATE SYNTHASE I from Rhizobium loti (Mesorhizobium FT loti) (517 aa), FASTA scores: opt: 1440, E(): 5.2e-72, FT (47.9% identity in 548 aa overlap); P20906|MDLC_PSEPU FT BENZOYLFORMATE DECARBOXYLASE (EC 4.1.1.7) from Pseudomonas FT putida (528 aa), FASTA scores: opt: 356, E(): 2.5e-12, FT (28.1% identity in 530 aa overlap); Q9L123|SC6D11.33c FT PUTATIVE DECARBOXYLASE from Streptomyces coelicolor (526 FT aa), FASTA scores: opt: 325, E(): 1.3e-10, (33.2% identity FT in 530 aa overlap); Q9RDF9|SCC57A.40c PUTATIVE ACETOLACTATE FT SYNTHASE from Streptomyces coelicolor (564 aa), FASTA FT scores: opt: 304, E(): 1.9e-09, (28.55% identity in 550 aa FT overlap); P94783 VALINE-SENSITIVE ACETOHYDROXY ACID FT SYNTHASE from Citrobacter freundii (561 aa), FASTA scores: FT opt: 278, E(): 5.1e-08, (25.8% identity in 550 aa overlap); FT Q42767|AHAS ACETOHYDROXYACID SYNTHASE (EC 4.1.3.18)from FT Gossypium hirsutum (Upland cotton) (659 aa), FASTA scores: FT opt: 278, E(): 5.8e-08, (26.15% identity in 558 aa FT overlap); etc. Note that other Mycobacterium tuberculosis FT proteins, e.g. FT O53250|MTV012.17c|ILVB_MYCTU|Rv3003c|MT3083|MTV012.17c, FT show better similarity to Acetolactate synthase I. SIMILAR FT TO OTHER ENZYMES WHICH REQUIRE TPP. COFACTOR: THIAMIN FT PYROPHOSPHATE (BY SIMILARITY)." FT /db_xref="GOA:Q7TWC2" FT /db_xref="HSSP:1JSC" FT /db_xref="InterPro:IPR011766" FT /db_xref="UniProtKB/TrEMBL:Q7TWC2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95725.1" FT /translation="MNGAQALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLT FT LFEGVATGAADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH FT KKYDAPLESDIDAVAGTVSGWVRRTEAAADVGADAEAAIAASRSGSQIATLILPADVCW FT SDGAHAAAGVPAQAAAAPVDVGPVAGVLRSGEPAMMLIGGDATRGPGLTAAARIVQATG FT ARWLCETFPTCLERGAGIPAVERLAYFAEGAAAQLDGVKHLVLAGARSPVSFFAYPGMP FT SDLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVAGASRPQLPTGDLTSVSAADV FT VGALLPERAIVVDESNTCGVLLPQATAGAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDR FT PVLCLESDGSAMYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAGSDPGPKAL FT DLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPGPHLIDVVVPSLVG" FT CDS complement(131658..132494) FT /transl_table=11 FT /gene="Mb3540c" FT /locus_tag="Mb3540c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3540c, -, len: 278 aa. Equivalent to Rv3510c, len: FT 278 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 278 aa overlap). Conserved hypothetical FT protein, similar to Q50662|Rv2303c|MTCY339.06 HYPOTHETICAL FT 34.6 KDA PROTEIN from Mycobacterium tuberculosis (307 aa), FT FASTA scores: opt: 416, E(): 1.2e-19, (35.7% identity in FT 255 aa overlap). Middle of the putative protein highly FT similar to N-terminal end of Q49860|B229_C2_182 FT HYPOTHETICAL 11.0 KDA PROTEIN from Mycobacterium leprae (95 FT aa), FASTA scores: opt: 304, E(): 7.9e-13, (83.65% identity FT in 55 aa overlap). Also some similarity with other FT bacterial proteins e.g. P95886 ORF C02006 from Sulfolobus FT solfataricus (269 aa), FASTA scores: opt: 293, E(): FT 9.6e-12, (31.3% identity in 198 aa overlap); Q9XDF3|NONC FT NONC PROTEIN from Streptomyces griseus subsp. griseus (317 FT aa), FASTA scores: opt: 270, E(): 3.4e-10, (29.95% identity FT in 227 aa overlap); Q54229|NONR MACROTETROLIDE FT ANTIBIOTIC-RESISTANCE PROTEIN from Streptomyces griseus FT (347 aa), FASTA scores: opt: 270, E(): 3.6e-10, (29.95% FT identity in 227 aa overlap); etc." FT /db_xref="GOA:Q7TWC1" FT /db_xref="InterPro:IPR006992" FT /db_xref="UniProtKB/TrEMBL:Q7TWC1" FT /protein_id="CAD95726.1" FT /translation="MTIDVWMQHPTQRFLHGDMFASLRRWTGGSIPETDIPIEATVSSM FT DAGGVTLGLLSAWRGPNGQDLISNDAVAEWVRLYPNRFAGLAAVDLDRPMAAVRELRRR FT VGEGFVGLRVVPWLWGAPPTDRRYYPLFAECVQSAVPFCTQVGHTGPLRPSETGRPIPY FT IDQVALDFPELVIVCGHVGYPWTEEMVAVARKHENVYIDTSAYTIKRLPGKLVRFMKTD FT TGQRKVLFGTNYPMIAHTHALTGLDELGLSDEARRDFLHGNAVRVFKLDPRGKVQT" FT CDS 132854..138670 FT /transl_table=11 FT /gene="PE_PGRS55" FT /locus_tag="Mb3541" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb3541, PE_PGRS55, len: 1938 aa. Equivalent to FT Rv3511 and Rv3512, len: 714 aa and 1079 aa, from FT Mycobacterium tuberculosis strain H37Rv, (99.4% identity in FT 706 aa overlap and 96.0% identity in 1117 aa overlap). FT Rv3511: Member of the Mycobacterium tuberculosis PE family, FT PGRS subfamily of gly-rich proteins, similar to others from FT Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. FT AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 2563, E(): FT 1.5e-94, (59.65% identity in 773 aa overlap); and upstream FT O53553|Rv3508|MTV023.15 (1901 aa), FASTA scores: opt: 2455, FT E(): 3.9e-90, (60.4% identity in 737 aa overlap); etc. FT Contains PS00583 pfkB family of carbohydrate kinases FT signature 1. Rv3512: Member of the Mycobacterium FT tuberculosis PE family, PGRS subfamily of gly-rich FT proteins, similar to others from Mycobacterium tuberculosis FT strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FT FASTA scores: opt: 3688, E(): 4.5e-130, (53.95% identity in FT 1136 aa overlap); and downstream O53559|Rv3514|MTV023.21 FT (1489 aa), FASTA scores: opt: 3611, E(): 3.6e-127, (53.15% FT identity in 1195 aa overlap); etc. Frameshifted PGRS FT protein, could be continuation of upstream MTV023.18, but FT no error could be found. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 FT exist as 2 genes. In Mycobacterium bovis, a 344 bp FT insertion results in a single product which is more similar FT to PE_PGRS55. There are also 3 additional in-frame FT insertions of 9 bp each (*-accggcgga, *-cggcaacgg and FT *-cggcggtac) and 2 substitutions compared to the homolog in FT Mycobacterium tuberculosis strain H37Rv." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TWC0" FT /protein_id="CAD95727.1" FT /translation="MSFVLISPEVVSAAAGDLANVGSTISAANKAAAAATTQVLAAGAD FT EVSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYMLAEATNVEQNLLNLIN FT APTQTLLGRPLIGDGANATTPGGAGGDGGLLFGSGGNGAPGAPGQAGGAGGSAGLLGNG FT GSGGAGGTGAPGGNGGNAGWLYGRGGVGGAGGIGGGTGGAGGHAWLFGHGGTGGIGGGP FT GGNGGWLLGNGGHGGAGGIGGGSGGAGGNGGWLLGNGGIGGAGGTGGGAGGTGGNAAWL FT LGGGGTGGAGGIGGGNGGHGGNGGWLLGNGGNGGLGGDGDGGTGGGHGGNGGNPGWLLG FT TAGGGGNGGAGSTGTAGGGSGGTGGDGGTGGRGGLLMGAGAGGHGGTGGAGGAGVDGGG FT AGGAGGAGGNGGAGGQAALLFGRGGTGGAGGYGGDGGGGGDGFDGTMAGLGGTGGSGGT FT GGDGGAPGNGGAGGAGQLLSHSGVAGASGKGGAGGTGGNGGAGSAGADAPAGSGAMGST FT GFAGGAGGDGGNGGGSGASQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGT FT GGTGGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAG FT GTGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGT FT GGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTG FT GTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGN FT AGAGGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTG FT GAAGTGTGGQQGNGGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGDAGKAGTGSA FT PGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGGTGGSGGAGGTGGDGGAANGGTAGAG FT GAGGNGGKGGDGGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGDGG FT DGAAGAVGISGATGAGDGGHGGTGGAGGNGGTGGAGGSGIDGVGGGTGGTGGNGGNGAI FT GGAGGDAGGSGNSGGNGGTGGKGGNAGAGGAAGSNGGTVGANGTGGDGGNGGAAGAATA FT GSNGGAGTGSAGGNGGTGGRGGSGGAGGDGIGGVGGGKGGNGADGEVGGAGGAGGSGPN FT TSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGAGGTGGAGAASSATNGG FT SGGAGGTGGAGGTGGAGGDGVGGAGGGNGGHGGDAGDGGNGANGNNRSSGSFLAAGGTG FT GAAGDGGQGGQGGAGGGAGGQGGAGGAGGTGGNGGNITGGTAGTAGAAGNGGAAGKGGA FT GGQGGTGGGTGGQGGAGGDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGAD FT GGSGGDGGDAGTGGNGGNGGNRNSGNGTGGAGGNGGGGANGGAGGAGGSGGGTGGNGGA FT GGDAGDAGNGGNGNGTGNGGNGGNGGIAGMGGNGGAGTGSGNGGNGGSGGNGGNAGMGG FT NSGTGSGDGGAGGNGGAAGTGGTGGDGGLTGTGGTGGSGGTGGDGGNGGNGGNGADNTA FT NMTAQAGGDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQGGAGGDGGNGAIGGHGPLTD FT DPGGNGGTGGNGGTGGTGGAGIGSLGGGTGGDGGNGGTGGNGGTGGEGGEVGGAGGTGG FT AAGNGGDGGTGGTGGGDGGAGGTGGTGGTGGLGDPRVGGSGGDGGTGGSGGAAGNGGNG FT GNAGAGGNGNGGTGGAGGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGT FT GSGGTGGDGGTGGGGGNGGTGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGGAGGKG FT GSGGV" FT CDS complement(138799..139455) FT /transl_table=11 FT /gene="fadD18" FT /locus_tag="Mb3542c" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD18 (FRAGMENT) FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb3542c, fadD18, len: 218 aa. Equivalent to Rv3513c, FT len: 218 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 218 aa overlap). Probable fadD18, FT fatty-acid-CoA synthetase (C-terminal fragment) (EC FT 6.2.1.-), almost identical to C-terminal end of downstream FT O53560|FADD19|Rv3515c|MTV023.22c, probably result of FT partial gene duplication. Also similar at the C-terminus to FT other fatty-acid-CoA synthetases e.g. Q9EXL2|FADD from FT Streptomyces griseus (540 aa), FASTA scores: opt: 586, E(): FT 1.2e-28, (52.45% identity in 185 aa overlap); AAB87139|MIG FT MEDIUM CHAIN ACYL-COA SYNTHETASE PRECURSOR from FT Mycobacterium avium (550 aa), FASTA scores: opt: 506, E(): FT 9.5e-24, (50.0% identity in 150 aa overlap); Q9A7C3|CC1801 FT PUTATIVE 4-COUMARATE--COA LIGASE from Caulobacter FT crescentus (561 aa), FASTA scores: opt: 430, E(): 4.4e-19, FT (45.75% identity in 153 aa overlap); Q9KDT0|BH1131 ACID-COA FT LIGASE from Bacillus halodurans (546 aa), FASTA scores: FT opt: 338, E(): 1.9e-13, (38.05% identity in 142 aa FT overlap); Q9RTR4|DR1692 LONG-CHAIN FATTY ACID--COA LIGASE FT from Deinococcus radiodurans (584 aa), FASTA scores: opt: FT 331, E(): 5.3e-13, (35.15% identity in 145 aa overlap); FT etc. Start uncertain." FT /db_xref="GOA:Q7TWB9" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TWB9" FT /protein_id="CAD95728.1" FT /translation="MAASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAV FT RPARTLAKKGNIPVGYYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVS FT INSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDS FT FVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS" FT CDS 139501..142479 FT /transl_table=11 FT /gene="PE_PGRS57" FT /locus_tag="Mb3543" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb3543, PE_PGRS57, len: 992 aa. Similar to Rv3514, FT len: 1489 aa, from Mycobacterium tuberculosis strain H37Rv, FT (80.6% identity in 1133 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, similar to others from Mycobacterium FT tuberculosis strains H37Rv and CDC1551 e.g. AAK47971 (1715 FT aa) FASTA scores: opt: 6940, E(): 0, (67.0% identity in FT 1713 aa overlap); and upstream FT O53553|YZ08_MYCTU|Rv3508|MTV023.15 (1901 aa), FASTA scores: FT opt: 6598,E(): 0, (71.05% identity in 1533 aa overlap). FT Contains two PS00583 pfkB family of carbohydrate kinases FT signatures 1. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, insertions of 9 bp (*-gcgggcggc) and FT 285 bp, and deletions of 240 bp, 951 bp and 609 bp, lead to FT shorter product compared to the homolog in Mycobacterium FT tuberculosis strain H37Rv (992 aa versus 1489 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TWB8" FT /protein_id="CAD95729.1" FT /translation="MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGAD FT EVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAAAAEQIVLGVIN FT APTQALLGRPLIGDGANATTPGGAGGAGGLLFGNGGAGAAGAPGQAGGPGGPAGLWGNG FT GPGGAGGSGGGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVGG FT AGGGTGGAGGRAELLFGAGGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGAGG FT AGGQGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGGMGG FT AGGAGADNPTGIGGTGGDGGTGGSAGEGGAGGAAGQLFSASGAAGNAGVGGAGGQGGDG FT GAGGAGADADQPGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGTGGQGGMGGAGG FT AGADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGQGGDGG FT AGGAGADADQPGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGTGGQGGAGGAGGA FT GADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGQGGDGGA FT GGAGGAGGSSGAGGTNGSGGAGGTGGQGGAGGAGGAGADNPTGIGGTGGDGGTGGAAGA FT GGAGGAAGTGGTGGMIGTTGNAGVGGAGGQGGDGGAGGAGADADQPGATGGTGFAGGAG FT GAGGAGGSSGAGGTNGSGGAGGTGGQGGAGGAGISFSNGSNGGTGGTGGVGGTGGDGGN FT AGTGAGDPGKGGTGGTGGSGGAGGSGGANFNGGTGGTGGTGGTGGKGGMGGIAGDGGPG FT GDGGNAGVGGKGGTNGNGGSGGTGGTGGPGGSGGAPTGSGTGGKGGAGGDGGDGADGGA FT ATGVGDGGDGGNGGNGGNGGTGVGSPGGLGGAGGTGGLGGAGAGGGADGDDGDDGQPGN FT NGS" FT CDS complement(143040..144686) FT /transl_table=11 FT /gene="fadD19" FT /locus_tag="Mb3544c" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD19 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb3544c, fadD19, len: 548 aa. Equivalent to Rv3515c, FT len: 548 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 548 aa overlap). Probable fadD19, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar (or with FT similarity) to many e.g. Q9EXL2|FADD FADD PROTEIN from FT Streptomyces griseus (540 aa), FASTA scores: opt: 1449, FT E(): 1.5e-81, (46.0% identity in 535 aa overlap); FT AAB87139|MIG MEDIUM CHAIN ACYL-COA SYNTHETASE PRECURSOR FT from Mycobacterium avium (550 aa), FASTA scores: opt: 1226, FT E(): 7.6e-68, (40.7% identity in 543 aa overlap); FT Q9A7C3|CC1801 PUTATIVE 4-COUMARATE--COA LIGASE from FT Caulobacter crescentus (561 aa), FASTA scores: opt: 979, FT E(): 1.2e-52, (34.05% identity in 531 aa overlap); FT O28502|AF1772 LONG-CHAIN-FATTY-ACID--COA LIGASE (FADD-7) FT from Archaeoglobus fulgidus (569 aa), FASTA scores: opt: FT 560, E(): 6.9e-27, (29.3% identity in 543 aa overlap); FT Q9A8N2|CC1321 LONG-CHAIN-FATTY-ACID--COA LIGASE from FT Caulobacter crescentus (583 aa), FASTA scores: opt: 544, FT E(): 6.7e-26, (27.2% identity in 518 aa overlap); FT P29212|LCFA_ECOLI|FADD|OLDD|B1805 FT LONG-CHAIN-FATTY-ACID--COA LIGASE from Escherichia coli FT strain K12 (561 aa), FASTA scores: opt: 460, E(): 4e-22, FT (26.3% identity in 567 aa overlap); etc. Contains PS00455 FT Putative AMP-binding domain signature. Note that upstream FT MTV023.20c|Rv3513c|fadD18 is identical to C-terminal part FT of FADD19|Rv3515c|MTV023.22c (probably result of partial FT gene duplication)." FT /db_xref="GOA:Q7TWB7" FT /db_xref="HSSP:1AMU" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TWB7" FT /protein_id="CAD95730.1" FT /translation="MAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAH FT HLIDQGVQKDDKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMV FT ALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGVEFYSAIAAGSPERDFGE FT RSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEFVKDEYDLAKAAAANPP FT MIRYPIPPMIHGATQSATWMALFSGQTTVLAPEFNADEVWRTIHKHKVNLLFFTGDAMA FT RPLVDALVKGNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT FT SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTA FT ETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVF FT DALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSLWFVDEVKRS FT PAGKPDYRWAKEQTEARPADDVHAGHVTSGG" FT CDS 144760..145551 FT /transl_table=11 FT /gene="echA19" FT /locus_tag="Mb3545" FT /product="POSSIBLE ENOYL-COA HYDRATASE ECHA19 (ENOYL FT HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)" FT /EC_number="4.2.1.17" FT /note="Mb3545, echA19, len: 263 aa. Equivalent to Rv3516, FT len: 263 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 263 aa overlap). Possible echA19, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to other e.g. FT Q9ZHG2|ECHA1 from Rhodococcus fascians (275 aa) FASTA FT scores: opt: 613, E(): 6.4e-32, (45.15% identity in 259 aa FT overlap); P76082|PAAF_ECOLI|B1393 from Escherichia coli FT strain K12 (255 aa), FASTA scores: opt: 523, E(): 3.3e-26, FT (33.6% identity in 256 aa overlap); Q9I393|PA1629 from FT Pseudomonas aeruginosa (261 aa), FASTA scores: opt: 475, FT E(): 3.8e-23, (36.85% identity in 247 aa overlap); etc. FT Also similar to many carnitine racemases eg FT BAB52369|MLL6015 from Rhizobium loti (Mesorhizobium loti) FT (257 aa), FASTA scores: opt: 546, E(): 1.1e-27, (36.65% FT identity in 251 aa overlap). Similar to several putative FT enoyl-CoA hydratases from Mycobacterium tuberculosis, e.g. FT P96404|ECHA1|Rv0222|MTCY08D5.17 (262 aa), FASTA scores: FT opt: 630, E(): 5.1e-33, (44.5% identity in 254 aa overlap); FT and O53783|ECHA5|Rv0675|MTV040.03 (263 aa) FASTA scores: FT opt: 499, E(): 1.1e-24, (40.5% identity in 252 aa overlap). FT COULD BELONG TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY." FT /db_xref="GOA:Q7TWB6" FT /db_xref="HSSP:1HZD" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:Q7TWB6" FT /protein_id="CAD95731.1" FT /translation="MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVD FT NDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSFKDGSYDPSRIDALLKGRRLTKPLI FT AAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTLACD FT LLLTGRHITAAEAKEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETEC FT MPENEAFKIDTQIGIKVFLSDDAKEGPRAFAEKRAPNFQNR" FT CDS 145647..146486 FT /transl_table=11 FT /gene="Mb3546" FT /locus_tag="Mb3546" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3546, -, len: 279 aa. Equivalent to Rv3517, len: FT 279 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 279 aa overlap). Hypothetical protein, FT similar to several hypothetical mycobacterial proteins e.g. FT P71763|Rv1482c|MTCY277.03c from Mycobacterium tuberculosis FT strain H37Rv (339 aa) (alias AAK45794|MT1529 from M. FT tuberculosis strain CDC1551 (292 aa) but longer) FASTA FT scores: opt: 1040, E(): 3.7e-60, (59.0% identity in 273 aa FT overlap); O07396|MAV346 from M. avium (346 aa) FASTA FT scores: opt: 1018, E(): 1e-58, (57.2% identity in 278 aa FT overlap); O53421|Rv1073|MTV017.26 from Mycobacterium FT tuberculosis strain H37Rv (283 aa), FASTA scores: opt: 903, FT E(): 2.4e-51, (48.0% identity in 277 aa overlap); FT Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa) FT FASTA scores: opt: 158, E(): 0.0015, (41.8% identity in 55 FT aa overlap); etc." FT /db_xref="UniProtKB/TrEMBL:Q7TWB5" FT /protein_id="CAD95732.1" FT /translation="MIEPFLGSEAIASGALTRHRLRSAYATIHPDVYVSPGADLTAWSR FT AQAAWLWSRRRGVIAGQSAAAMHGAKWVDARQAAELLYDHRRPPAGIHTWSDRVADDEI FT QPISGMNTTTPARTALDLARRYPVGKAVAAIDALARATDLKLADVEMLAERYRGSRGIR FT NARIALDLVDPGAESPRETWLRLLLIRAGFPRPQTQIPVYDEYGQLVAVIDMGWAGIKV FT GVDYEGDHHRTDRRTFNKDIKRAEALTELGWTDVRVTVEDTEGGIIWRVSAAWQRRT" FT CDS complement(146541..147122) FT /transl_table=11 FT /gene="cyp142b" FT /locus_tag="Mb3547c" FT /product="PROBABLE CYTOCHROME P450 MONOOXYGENASE 142 FT CYP142B [SECOND PART]" FT /EC_number="1.14.-.-" FT /note="Mb3547c, cyp142b, len: 193 aa. Equivalent to 3' end FT of Rv3518c, len: 398 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 193 aa overlap). Probable FT cyp142, cytochrome P450 monoxygenase (EC 1.14.-.-), member FT of Cytochrome P450 family and similar to many e.g. FT Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FT FASTA scores: opt: 798, E(): 2e-43, (36.7% identity in 403 FT aa overlap); P33271|CPXK_SACER|CYP107B1 from FT Saccharopolyspora erythraea (Streptomyces erythraeus) (405 FT aa), FASTA scores: opt: 725, E(): 9.1e-39, (37.1% identity FT in 407 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from FT Streptomyces coelicolor (411 aa), FASTA scores: opt: 691, FT E(): 1.3e-36, (37.2% identity in 317 aa overlap); etc. Also FT similar to FT Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from FT Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA FT scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa FT overlap). Equivalent to AAK47979 from Mycobacterium FT tuberculosis strain CDC1551 (372 aa) but longer 26 aa. FT Contains PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, cyp142 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT deletion (c-*) splits cyp142 into 2 parts, cyp142a and FT cyp142b." FT /db_xref="GOA:Q7TWB4" FT /db_xref="HSSP:1CPT" FT /db_xref="InterPro:IPR002397" FT /db_xref="UniProtKB/TrEMBL:Q7TWB4" FT /protein_id="CAD95733.1" FT /translation="MSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNR FT DQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESAN FT FDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVA FT DDSVLPLRPANFVSGLESMPVVFTPSPPLG" FT CDS complement(147119..147736) FT /transl_table=11 FT /gene="cyp142a" FT /locus_tag="Mb3548c" FT /product="PROBABLE CYTOCHROME P450 MONOOXYGENASE 142 FT CYP142A [FIRST PART]" FT /EC_number="1.14.-.-" FT /note="Mb3548c, cyp142a, len: 205 aa. Equivalent to 5' end FT of Rv3518c, len: 398 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 197 aa overlap). Probable FT cyp142, cytochrome P450 monoxygenase (EC 1.14.-.-), member FT of Cytochrome P450 family and similar to many e.g. FT Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FT FASTA scores: opt: 798, E(): 2e-43, (36.7% identity in 403 FT aa overlap); P33271|CPXK_SACER|CYP107B1 from FT Saccharopolyspora erythraea (Streptomyces erythraeus) (405 FT aa), FASTA scores: opt: 725, E(): 9.1e-39, (37.1% identity FT in 407 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from FT Streptomyces coelicolor (411 aa), FASTA scores: opt: 691, FT E(): 1.3e-36, (37.2% identity in 317 aa overlap); etc. Also FT similar to FT Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from FT Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA FT scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa FT overlap). Equivalent to AAK47979 from Mycobacterium FT tuberculosis strain CDC1551 (372 aa) but longer 26 aa. FT Contains PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, cyp142 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT deletion (c-*) splits cyp142 into 2 parts, cyp142a and FT cyp142b." FT /db_xref="GOA:Q7TWB3" FT /db_xref="HSSP:1IO7" FT /db_xref="InterPro:IPR002397" FT /db_xref="UniProtKB/TrEMBL:Q7TWB3" FT /protein_id="CAD95734.1" FT /translation="MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAAST FT YQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEA FT SIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFL FT SSHVSQEDFQITMDAFAAYNDFTRATIAARRADPPTTWSACW" FT CDS 147765..148475 FT /transl_table=11 FT /gene="Mb3549" FT /locus_tag="Mb3549" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3549, -, len: 236 aa. Equivalent to Rv3519, len: FT 236 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 236 aa overlap). Hypothetical unknown FT protein. The C-terminal end is highly similar to N-terminal FT end of AAK47980|MT3620 HYPOTHETICAL 7.8 KDA PROTEIN from FT Mycobacterium tuberculosis strain CDC1551 (73 aa), FASTA FT scores: opt: 279, E(): 9.4e-12, (95.65% identity in 46 aa FT overlap). Start uncertain." FT /db_xref="UniProtKB/TrEMBL:Q7TWB2" FT /protein_id="CAD95735.1" FT /translation="MPVSQHTIAGTVLTMPVRIRTANLHSAMFSVPADPAQRLIDYSGL FT RVCEYLPGKAIVMQMLVRYVDGDLGRYHEYGTAIMVNPPGTQRRGPRALTRAAAFIHHL FT PVDQVFTLEAGRTIWGFPKIMADFNVTDGRRFGFDVSADGRLIAGIEFSTGLPVPTLGW FT QMLKTYSHHDGVTREIPWEMKVSGLRARLGGARLRLGDHPYAKELASLGLPKRALLSQS FT AANVEMTFGDGHPI" FT CDS complement(148540..149583) FT /transl_table=11 FT /gene="Mb3550c" FT /locus_tag="Mb3550c" FT /product="POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3550c, -, len: 347 aa. Equivalent to Rv3520c, len: FT 347 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 347 aa overlap). Possible coenzyme FT F420-dependent oxidoreductase (EC 1.-.-.-), equivalent to FT Q9CCV8|ML0348 POSSIBLE COENZYME F420-DEPENDENT FT OXIDOREDUCTASE from Mycobacterium leprae (350 aa), FASTA FT scores: opt: 2029, E(): 9.1e-120, (86.85% identity in 342 FT aa overlap). Similar to many coenzyme F420-dependent FT enzymes (and other proteins) e.g. Q9AD98|SCI52.11c PUTATIVE FT ATP/GTP-BINDING PROTEIN from Streptomyces coelicolor (351 FT aa), FASTA scores: opt: 859, E(): 1.6e-46, (41.9% identity FT in 346 aa overlap); Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE FT from Streptomyces coelicolor (341 aa), FASTA scores: opt: FT 800, E(): 7.9e-43, (38.95% identity in 339 aa overlap); FT Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from FT Streptomyces violaceoruber (343 aa), FASTA scores: opt: FT 354, E(): 6.7e-15, (34.2% identity in 336 aa overlap); FT Q49598|MER COENZYME F420-DEPENDENT FT N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from FT Methanopyrus kandleri (349 aa), FASTA scores: opt: 283, FT E(): 1.9e-10, (26.75% identity in 329 aa overlap); FT Q58929|MER|MJ1534 F420-DEPENDENT FT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from FT Methanococcus jannaschii (331 aa), FASTA scores: opt: 227, FT E(): 5.8e-07, (26.35% identity in 334 aa overlap); FT O27784|MTH1752 COENZYME F420-DEPENDENT N5,N10-METHYLENE FT TETRAHYDROMETHANOPTERIN REDUCTASE from Methanobacterium FT thermoautotrophicum (321 aa), FASTA scores: opt: 207, E(): FT 1e-05, (27.4% identity in 336 aa overlap); etc. Also FT similar to Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 FT HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium FT tuberculosis (340 aa), FASTA scores: opt: 313, E(): FT 2.5e-12, (28.0% identity in 311 aa overlap)." FT /db_xref="GOA:Q7TWB1" FT /db_xref="InterPro:IPR019951" FT /db_xref="UniProtKB/TrEMBL:Q7TWB1" FT /protein_id="CAD95736.1" FT /translation="MEAGMKLGLQLGYWGAQPPQNHAELVAAAEDAGFDTVFTAEAWGS FT DAYTPLAWWGSSTQRVRLGTSVIQLSARTPTACAMAALTLDHLSGGRHILGLGVSGPQV FT VEGWYGQRFPKPLARTREYIDIVRQVWARESPVTSAGPHYRLPLTGEGTTGLGKALKPI FT THPLRADIPIMLGAEGPKNVALAAEICDGWLPIFYSPRMAGMYNEWLDEGFARPGARRS FT REDFEICATAQVVITDDRAAAFAGIKPFLALYMGGMGAEETNFHADVYRRMGYTQVVDE FT VTKLFRSGRKDEAAEIIPDELVDDAVIVGDIDHVRKQMAVWEAAGVTMMVVTAGSAEQV FT RDLAALV" FT CDS 149736..150647 FT /transl_table=11 FT /gene="Mb3551" FT /locus_tag="Mb3551" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3551, -, len: 303 aa. Equivalent to Rv3521, len: FT 303 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 303 aa overlap). Conserved hypothetical FT protein, similar to (although longer than) other conserved FT hypothetical proteins e.g. O29296|AF0966 from Archaeoglobus FT fulgidus (176 aa), FASTA scores: opt: 286, E(): 5.4e-11, FT (31.15% identity in 170 aa overlap); O30036|AF0203 from FT Archaeoglobus fulgidus (149 aa) FASTA scores: opt: 259, FT E(): 2.3e-09, (33.8% identity in 142 aa overlap); FT O29297|AF0965 from Archaeoglobus fulgidus (154 aa), FASTA FT scores: opt: 241, E(): 3.2e-08, (31.4% identity in 137 aa FT overlap); Q9Y995|APE2390 from Aeropyrum pernix (157 aa), FT FASTA scores: opt: 204, E(): 6.8e-06, (27.45% identity in FT 153 aa overlap); BAB60424|TVG1322512 from Thermoplasma FT volcanium (164 aa), FASTA scores: opt: 183, E(): 0.00015, FT (29.75% identity in 148 aa overlap); etc. Equivalent to FT AAK47982 from Mycobacterium tuberculosis strain CDC1551 FT (334 aa) but shorter 31 aa." FT /db_xref="InterPro:IPR002878" FT /db_xref="UniProtKB/TrEMBL:Q7TWB0" FT /protein_id="CAD95737.1" FT /translation="MGPTLSRFFTALRARRIVGVRGSDGRVHVPPVEYDPVTYEPLSEM FT VPVSSVGTVASWTWQPEPLAGQPLDRPFAWALIKLDGADTLLMHAVDVGTAGPSAIHTG FT ARVHAHWADQPVGAITDIACFALGETAEPVAAHKTEDARDPVTMIVTPIQLEIQHTASH FT EESAYLRAIAQGKLVGARTGKTGKVYFPPHGADPATGKPTSEFVELPDKGTVTTFAIVN FT IPFLGQRIKPPYVAAYVLLDGADIPFLHLVSDVDAHQVRMGMRVEAVWKPRERWGLGID FT NIEYFRPTGEPDADYDTYKHHL" FT CDS 150663..151727 FT /transl_table=11 FT /gene="Mb3552" FT /locus_tag="Mb3552" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3552, -, len: 354 aa. Equivalent to Rv3522, len: FT 354 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 354 aa overlap). Possible lipid carrier FT protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar to FT several e.g. O30103|AF0134 3-KETOACYL-COA THIOLASE (ACAB-4) FT from Archaeoglobus fulgidus (398 aa) FASTA scores: opt: FT 352, E(): 5.3e-15, (30.45% identity in 381 aa overlap); FT O29295|AF0967 3-KETOACYL-COA THIOLASE (ACAB-9) from FT Archaeoglobus fulgidus (400 aa) FASTA scores: opt: 312, FT E(): 1.8e-12, (28.05% identity in 367 aa overlap); FT O29294|AF0968 3-KETOACYL-COA THIOLASE (ACAB-10) from FT Archaeoglobus fulgidus (388 aa), FASTA scores: opt: 293, FT E(): 2.9e-11, (25.9% identity in 309 aa overlap); FT O58409|PH0676 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER FT PROTEIN (ACETHYL CoA SYNTHETASE) (EC 6.2.1.-) from FT Pyrococcus horikoshii (389 aa), FASTA scores: opt: 292, FT E(): 3.3e-11, (25.8% identity in 368 aa overlap); FT Q9Y9A3|APE2382 LONG HYPOTHETICAL NON SPECIFIC FT LIPID-TRANSFER PROTEIN from Aeropyrum pernix (360 aa) FASTA FT scores: opt: 270, E(): 7.8e-10, (27.25% identity in 363 aa FT overlap); Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC FT LIPID-TRANSFER PROTEIN from Aeropyrum pernix (400 aa), FT FASTA scores: opt: 258, E(): 4.9e-09, (26.45% identity in FT 306 aa overlap); etc. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /db_xref="GOA:Q7TWA9" FT /db_xref="InterPro:IPR002155" FT /db_xref="UniProtKB/TrEMBL:Q7TWA9" FT /protein_id="CAD95738.1" FT /translation="MSVRDIAVVGFAHAPHVRRTDGTTNGVEMLMPCFAQLYDELGITK FT ADIGFWCSGSSDYLAGRAFSFISAIDSIGAVPPINESHVEMDAAWALYEAYIKLLTGEV FT DTALVYGFGKSSAGTLRRVLSRQTDPYTVAPLWPDSVSMAGLQARLGLDSGKWTHEQMA FT RVAFDSFTNARRVDSVEPPITVGELLARPFFADPLRRHDIAPITDGAAAVVLAADNRAR FT ELRENPAWITGIEHRIESPALGARDITESPSTKLAAKIATGGHTGDIDVAEIHGPFTHQ FT HLIVAEAIRIPGKTKVNPSGGPLAANPMFAAGLERIGFAAQHIWDGSARRVLAHATSGP FT ALQQNLVAVMEGRG" FT CDS 151744..152928 FT /transl_table=11 FT /gene="Mb3553" FT /locus_tag="Mb3553" FT /product="PROBABLE LIPID CARRIER PROTEIN OR KETO ACYL-COA FT THIOLASE" FT /EC_number="2.3.1.16" FT /note="Mb3553, -, len: 394 aa. Equivalent to Rv3523, len: FT 394 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 394 aa overlap). Probable lipid carrier FT protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar to FT several e.g. O30037|AF0202 3-KETOACYL-COA THIOLASE (ACAB-6) FT from Archaeoglobus fulgidus (380 aa) FASTA scores: opt: FT 782, E(): 1.7e-40, (38.35% identity in 386 aa overlap); FT Q9Y9A1|APE2384 LONG HYPOTHETICAL NON SPECIFIC FT LIPID-TRANSFER PROTEIN (ACETHYL CoA SYNTHETASE) (EC FT 6.2.1.-) from Aeropyrum pernix (394 aa), FASTA scores: opt: FT 626, E(): 5.9e-31, (35.75% identity in 386 aa overlap); FT BAB59210|TVG0067506 LIPID TRANSFER PROTEIN from FT Thermoplasma volcanium (390 aa), FASTA scores: opt: 591, FT E(): 8.1e-29, (34.35% identity in 384 aa overlap); FT Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER FT PROTEIN from Aeropyrum pernix (400 aa) FASTA scores: opt: FT 588, E(): 1.3e-28, (31.6% identity in 408 aa overlap); FT O30104|AF0133 3-KETOACYL-COA THIOLASE (ACAB-3) from FT Archaeoglobus fulgidus (411 aa) FASTA scores: opt: 583, FT E(): 2.6e-28, (39.8% identity in 412 aa overlap); FT O29811|AF0438 3-KETOACYL-COA THIOLASE (ACAB-8) from FT Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 574, FT E(): 8.8e-28, (30.95% identity in 388 aa overlap); etc." FT /db_xref="GOA:Q7TWA8" FT /db_xref="InterPro:IPR016038" FT /db_xref="UniProtKB/TrEMBL:Q7TWA8" FT /protein_id="CAD95739.1" FT /translation="MAGKLAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADSGSTFD FT DIDAVVVGKAPDFFEGVMMPELFMADAMGATGKPLIRVHTAGSVGGSTGVVAASLVQSG FT KYRRVLALAWEKQSESNAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPAHIGA FT MVAVKDRLNGSRNPLAHLQQPDITLEKVMASQMLWDPIRFDETCPSSDGACAVVVGDEE FT IADARLAQGHPVAWIHGTALRTEPLAFAGRDQVNPQAGRDAAAALWKAAGITSPIDEID FT AAEIYVPFSWFEPMWLENLGFAREGEGWKLTEAGETAIGGRLPVNPSGGVLSANPIGAS FT GLIRFAEAAIQVMGKAEARQVPGARKALGHAYGGGSQYFSMWVVGCEKPKQAAA" FT CDS 152970..154001 FT /transl_table=11 FT /gene="Mb3554" FT /locus_tag="Mb3554" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb3554, -, len: 343 aa. Equivalent to Rv3524, len: FT 343 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 343 aa overlap). Probable conserved FT membrane protein, showing some similarity to C-terminal FT part of putative Mycobacterium tuberculosis proteins FT O05871|P95308|PKND_MYCTU|Rv0931c|MT0958|MTCY08C9.08 FT serine-threonine protein kinase PknD (EC 2.7.1.-) (664 aa) FT FASTA scores: opt: 727, E(): 8.3e-36, (45.3% identity in FT 298 aa overlap); O53893|Rv0980c|MTV044.08c PGRS-FAMILY FT PROTEIN (457 aa), FASTA scores: opt: 208, E(): 4.4e-05, FT (33.75% identity in 166 aa overlap); and FT O53891|Rv0978c|MTV044.06c PGRS-FAMILY PROTEIN (331 aa) FT FASTA scores: opt: 153, E(): 0.062, (30.75% identity in 117 FT aa overlap). Contains PS00237 G-protein coupled receptors FT signature." FT /db_xref="InterPro:IPR013017" FT /db_xref="UniProtKB/TrEMBL:Q7TWA7" FT /protein_id="CAD95740.1" FT /translation="MVKFTPDSQTSVLRAGKCSGTLSPSRSRLQRGSWPVDSERRRYGW FT PRNRRTLAITGAAVVVVVTLAAIGYLIFEPKISGSSTSRQAASPTTPSPPSQVVVPIDL FT WNPDGVTVDLADAVYVADSGHKRLLKLPAGSNTPTTLPFTDTIGPGGVAVNSNRDVYVI FT DEDSHHVLKLAAGIEPPVELPFGSLGDAHGLAVDRSDSVYVVDYDNAKVLKLPPGADTP FT TELPFVGLDHPYDVAVDGAGTVYVTDSGHNRVVALTAGSATPVHLPFADLSFPAGVTVD FT RDDSVYVADLNNNRVLKLAAGSNAQSQLPFTGLFSPTDVAVDNDGAVYVIDFYNRMLKL FT PTA" FT CDS complement(154015..154539) FT /transl_table=11 FT /gene="Mb3555c" FT /locus_tag="Mb3555c" FT /product="POSSIBLE SIDEROPHORE-BINDING PROTEIN" FT /note="Mb3555c, -, len: 174 aa. Equivalent to Rv3525c, len: FT 174 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 174 aa overlap). Possible FT siderophore-binding protein, similar to ferripyochelin FT binding proteins (and related) e.g. Q9RSN5|DR2089 FT FERRIPYOCHELIN-BINDING PROTEIN from Deinococcus radiodurans FT (240 aa), FASTA scores: opt: 472, E(): 3.3e-21, (46.9% FT identity in 162 aa overlap); O59257|PH1591 LONG FT HYPOTHETICAL FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus FT horikoshii (173 aa), FASTA scores: opt: 431, E(): 6.7e-19, FT (40.0% identity in 170 aa overlap); Q9V158|FBP|PAB0393 FT FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus abyssi (173 FT aa), FASTA scores: opt: 429, E(): 8.9e-19, (39.4% identity FT in 170 aa overlap); BAB47820|MLR0180 FERRIPYOCHELIN BINDING FT PROTEIN-LIKE from Rhizobium loti (Mesorhizobium loti) (175 FT aa), FASTA scores: opt: 415, E(): 6.1e-18, (42.55% identity FT in 141 aa overlap); etc." FT /db_xref="GOA:Q7TWA6" FT /db_xref="InterPro:IPR001451" FT /db_xref="UniProtKB/TrEMBL:Q7TWA6" FT /protein_id="CAD95741.1" FT /translation="MPLFSFEGRSPRIDPTAFVAPTATLIGDVTIEAGASVWFNAVLRG FT DYAPVVVREGANVQDGAVLHAPPGIPVDIGPGATVAHLCVIHGVHVGSEALIANHATVL FT DGAVIGARCMIAAGALVVAGTQIPAGMLVTGAPAKVKGPIEGTGAEMWVNVNPQAYRDL FT AARHLAGLEPM" FT CDS 154654..155814 FT /transl_table=11 FT /gene="Mb3556" FT /locus_tag="Mb3556" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3556, -, len: 386 aa. Equivalent to Rv3526, len: FT 386 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 386 aa overlap). Hypothetical FT oxidoreductase (EC 1.-.-.-), highly similar, except in FT C-terminus (also longer 69 aa), to O69348|ORF12 PROTEIN FT (function unknown) from Rhodococcus erythropolis (316 aa) FT FASTA scores: opt: 1137, E(): 6.9e-65, (59.6% identity in FT 250 aa overlap). Also some similarity with several FT aminopyrrolnitrin oxidases (PRND proteins, involved in the FT pathway for pyrrolnitrin biosynthesis, a secondary FT metabolite derived from tryptophan which has strong FT anti-fungal activity) e.g. Q9RPG0|PRND from Myxococcus FT fulvus (379 aa), FASTA scores: opt: 322, E(): 4.4e-13, FT (25.85% identity in 352 aa overlap); Q9RPG4|PRND from FT Burkholderia cepacia (Pseudomonas cepacia) (373 aa) FASTA FT scores: opt: 306, E(): 4.5e-12, (25.2% identity in 373 aa FT overlap); P95483|PRND from Pseudomonas fluorescens (363 FT aa), FASTA scores: opt: 305, E(): 5.1e-12, (25.0% identity FT in 372 aa overlap); etc. And also some similarity to other FT putative enzymes like dioxygenases, oxidases, vanillate FT O-demethyl oxygenase, etc." FT /db_xref="GOA:Q7TWA5" FT /db_xref="InterPro:IPR017941" FT /db_xref="UniProtKB/TrEMBL:Q7TWA5" FT /protein_id="CAD95742.1" FT /translation="MSTDTSGVGVREIDAGALPTRYARGWHCLGVAKDYLEGKPHGVEA FT FGTKLVVFADSHGDLKVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRWGGDGRCKLVPY FT ARRTPRMARTRSWTTDVRSGLLFVWHDHEGNPPDPAVRIPEIPEAASDEWTDWRWNRIL FT IEGSNCRDIIDNVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDDLGTSYG FT EAHLDSEASYFGPSFMINWLHNRYGNYKSESILINCHYPVTQNSFVLQWGVIVEKPKGM FT SEEMTDKLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYEQFYVDV FT ADIKPEMVERFEIEVDTKRANEFWNAEVEKNLKSREVSDDVPAEQH" FT CDS 155820..156269 FT /transl_table=11 FT /gene="Mb3557" FT /locus_tag="Mb3557" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3557, -, len: 149 aa. Equivalent to Rv3527, len: FT 149 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 149 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TWA4" FT /protein_id="CAD95743.1" FT /translation="MPDDQPAVPDVDRLARSMLLLHGDHHDHNDSPEQHRTCGSWSKSR FT DFADDPQRAAAVREASRAERDRYLTSGLQPVDCRFCHVTVTVKRLGPGHTAVQWNTEAS FT RRCAYFTELRARGGDSARTRSCPRLTDSIEHAVAEGYLEHHDPNR" FT CDS complement(156694..157407) FT /transl_table=11 FT /gene="Mb3558c" FT /locus_tag="Mb3558c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3558c, -, len: 237 aa. Equivalent to Rv3528c, len: FT 237 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 237 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TWA3" FT /protein_id="CAD95744.1" FT /translation="MMLDRLRQGGYWLVRGKINLIDRAFTSCRIESFADLGAVWGVEGA FT YTFRALDKYPVKEAVLVDGRITPTVAARANSYPQLRVIEGNFGDQEIADKVGNVDALFL FT FDVLLHQVSPDWDTILDMYAKNVRCLLIYNQQWIGSTTTVRLLDLGEKHYFRNVPHSKL FT NKAYRDLFQKLDKKHPDHDKPWRDIPDIWQWGITDADLESKASELGFKLLYKEDCRGFG FT WLPNIQNRAFLFARQ" FT CDS complement(158099..159253) FT /transl_table=11 FT /gene="Mb3559c" FT /locus_tag="Mb3559c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3559c, -, len: 384 aa. Equivalent to Rv3529c, len: FT 384 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 384 aa overlap). Conserved hypothetical FT protein, showing some similarity to FT Q50695|YM67_MYCTU|Rv2267c|MT2329|MTCY339.43 HYPOTHETICAL FT 46.1 KDA PROTEIN from Mycobacterium tuberculosis (388 aa) FT FASTA scores: opt: 261, E(): 1.6e-09, (27.25% identity in FT 253 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWA2" FT /protein_id="CAD95745.1" FT /translation="MTRRPDRKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLD FT AYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGT FT TALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDAQFTQHHAENPGYTGL FT HFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLN FT DAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFV FT GAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLS FT DEARQAMTTVHAESQSGARAPKHSYSLADYGLTVEMVKERFAGL" FT CDS complement(159253..160035) FT /transl_table=11 FT /gene="Mb3560c" FT /locus_tag="Mb3560c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3560c, -, len: 260 aa. Equivalent to Rv3530c, len: FT 260 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 260 aa overlap). Possible FT oxidoreductase (EC 1.-.-.-), similar to various FT oxidoreductases and hypothetical proteins e.g. FT BAB53258|Q987E5|MLL7083 PROBABLE OXIDOREDUCTASE from FT Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: FT opt: 405, E(): 5.3e-18, (33.45% identity in 263 aa FT overlap); Q9VNF3|CG12171 HYPOTHETICAL PROTEIN from FT Drosophila melanogaster (Fruit fly) (257 aa), FASTA scores: FT opt: 404, E(): 6.1e-18, (32.8% identity in 256 aa overlap); FT Q9A3X5|CC3076 OXIDOREDUCTASE (SHORT-CHAIN FT DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus FT (254 aa), FASTA scores: opt: 400, E(): 1.1e-17, (31.0% FT identity in 255 aa overlap); BAB50080|MLR3115 DEHYDROGENASE FT from Rhizobium loti (Mesorhizobium loti) (259 aa), FASTA FT scores: opt: 393, E(): 3e-17, (31.9% identity in 254 aa FT overlap); Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE FT 3-KETO-ACYL-REDUCTASE from Streptomyces antibioticus (273 FT aa), FASTA scores: opt: 388, E(): 6.3e-17, (31.6% identity FT in 250 aa overlap); etc." FT /db_xref="GOA:Q7TWA1" FT /db_xref="HSSP:1E7W" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TWA1" FT /protein_id="CAD95746.1" FT /translation="MTGMLKRKVIVVSGVGPGLGTTLAHRCARDGADLVLAARSAERLD FT DVAKQIIDTGRRAVAVRTDITDDDDVSNLVQATLAAYGKADVLINNAFRVPSMKPLAGT FT TFEHIRDAIELSALGTLRLIQAFTPALAQSHGAIVNVNSMVIRHSQPKYGTYKMAKSVL FT LAMSHSLATELGEQGIRVNSVAPGYIWGDTLKSYFDHQAGKYGTTVDQIYQATAANSDL FT KRLPTEDEVASAILFLASDLASGITGQTLDVNCGEYHT" FT CDS complement(160032..161159) FT /transl_table=11 FT /gene="Mb3561c" FT /locus_tag="Mb3561c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3561c, -, len: 375 aa. Equivalent to Rv3531c, len: FT 375 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 375 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TWA0" FT /protein_id="CAD95747.1" FT /translation="MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAGCIAGCMH FT LAFDYERDHPFLQSGTGPFTKMGLDNPDTLYFGTRLQANRDYVVSGRRGTTTDLSFQLL FT GGEYTDYNVPASQAAFDDRELDIAADGSFEWRLRPSAPGQLVIREVYGDWSQQRGTLAI FT ARLDTVGTAPPPLTRELMEKRYATAGSQLVNRVKTWLQFPQWFYLNIPVNTMVAPRLTP FT GGLATQYSSAGHFELRPGQALVITVPVSDAPYLGFQLGSMWYISLDYINHQTSLNASQA FT QADPDGKVRIVVAEQNPGVTNWVETLGHRRGFLQFRWQRVSRELTEADGPTVELVDFDA FT IPAALPHYQHNKISEDDWRARIALRQRQIATRMLG" FT CDS 161558..162778 FT /transl_table=11 FT /gene="PPE61" FT /locus_tag="Mb3562" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3562, PPE61, len: 406 aa. Equivalent to Rv3532, FT len: 406 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 406 aa overlap). Member of the FT Mycobacterium tuberculosis PPE protein family, similar to FT many, e.g. O53956|Rv1807|MTV049.29 (403 aa), FASTA scores: FT opt: 954, E(): 1.1e-43, (44.1% identity in 417 aa overlap)" FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TW99" FT /protein_id="CAD95748.1" FT /translation="MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAELQSAAE FT TYRSVIASLTGWQWLGPSSVRMGAAVTPYVEWLTTTAAQARQTATQITAAATGFEQAFA FT MTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALETQYAEMWEQDATAMYDYAATSAAA FT RTLTPFTSPQQDTNSAGLPAQSAEVSRATANAGAADGNWLGNLLEEIGILLLPIAPELT FT PFFLEAGEIVNAIPFPSIVGDEFCLLDGLLAWYATIGSINNINSMGTGIIGAEKNLGIL FT PELGSAAAAAAPPPADIAPAFLAPLTSMAKSLSDGALRGPGEVSAAMRGAGTIGQMSVP FT PAWKAPAVTTVRAFDATPMTTLPGGDAPAAGVPGLPGMPASGAGRAGVVPRYGVRLTVM FT TRPLSGG" FT CDS complement(162920..164668) FT /transl_table=11 FT /gene="PPE62" FT /locus_tag="Mb3563c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3563c, PPE62, len: 582 aa. Equivalent to Rv3533c, FT len: 582 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 582 aa overlap). Member of the FT Mycobacterium tuberculosis PPE protein family, similar to FT many, e.g. O53309|Rv3159c|MTV014.03c (590 aa) FASTA scores: FT opt: 2289, E(): 2.3e-95, (63.5% identity in 600 aa FT overlap)." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7TW98" FT /protein_id="CAD95749.1" FT /translation="MNYAVLPPELNSLRMFTGAGSAPMLAAAVAWDGLAAELGSAASSF FT GSVTSDLASQAWQGPAAAAMAAAAAPYAGWLSAAAARAAGAAAQAKAVASAFEAARAAT FT VHPLLVAANRNAFAQLVMSNWFGLNAPLIAAVEGAYEQMWAADVAAMVGYHSGASAAAE FT QLVPFQQALQQLPNLGIGNIGNANLGGGNTGDLNTGNGNIGNTNLGSGNRGDANLGSGN FT IGNSNVGGGNVGNGNFGSGNGRAGLPGSGNVGNGNLGNSNLGSGNTGNSNVGFGNTGNN FT NVGTGNAGSGNIGAGNTGSSNWGFGNNGIGNIGFGNTGNGNIGFGLTGNNQVGIGGLNS FT GSGNIGLFNSGTNNVGFFNSGNGNLGIGNSSDANVGIGNSGATVGPFVAGHNTGFGNSG FT SLNTGMGNAGGVNTGFGNGGAINLGFGNSGQLNAGSFNAGSINTGNFNSGQGNTGDFNA FT GVRNTGWSNSGLTNTGAFNAGSLNTGFGAVGTGSGPNSGFGNAGTNNSGFFNTGVGSSG FT FQNGGSNNSGLQNAVGTVIAAGFGNTGAQTVGIANSGVLNSGFFNSGVHNSGGFNSENQ FT RSGFGN" FT CDS complement(164767..165807) FT /transl_table=11 FT /gene="Mb3564c" FT /locus_tag="Mb3564c" FT /product="PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA)" FT /EC_number="4.1.3.-" FT /note="Mb3564c, -, len: 346 aa. Equivalent to Rv3534c, len: FT 346 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 346 aa overlap). Probable FT 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), highly FT similar to others e.g. P51015|BPHI_PSESP from Pseudomonas FT sp. strain LB400 (346 aa), FASTA scores: opt: 1150, E(): FT 2.3e-61, (51.35% identity in 331 aa overlap); Q52040|BPHX3 FT from Pseudomonas pseudoalcaligenes (346 aa), FASTA scores: FT opt: 1147, E(): 3.5e-61, (51.35% identity in 331 aa FT overlap); P51017|NAHM_PSEPU from Pseudomonas putida (346 FT aa), FASTA scores: opt: 1145, E(): 4.7e-61, (50.9% identity FT in 330 aa overlap) (see citation below); FT P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain FT K12 (337 aa), FASTA scores: opt: 1133, E(): 2.4e-60, (52.0% FT identity in 327 aa overlap); O24833|ATDG from Acinetobacter FT sp (340 aa), FASTA scores: opt: 1132, E(): 2.7e-60, (50.45% FT identity in 331 aa overlap); etc. Note that also highly FT similar to Q9ZI56|NAHM 2-OXO-4-HYDROXYPENTANOATE ALDOLASE FT from Pseudomonas stutzeri (Pseudomonas perfectomarina) (346 FT aa) FASTA scores: opt: 1168, E(): 2e-62, (51.05% identity FT in 331 aa overlap) (see citation below)." FT /db_xref="GOA:Q7TW97" FT /db_xref="InterPro:IPR000891" FT /db_xref="UniProtKB/TrEMBL:Q7TW97" FT /protein_id="CAD95750.1" FT /translation="MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVI FT EVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNG FT GSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQC FT VYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQID FT GSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNAL FT IMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDS FT GAAVTH" FT CDS complement(165804..166715) FT /transl_table=11 FT /gene="Mb3565c" FT /locus_tag="Mb3565c" FT /product="PROBABLE ACETALDEHYDE DEHYDROGENASE (ACETALDEHYDE FT DEHYDROGENASE [ACETYLATING])" FT /EC_number="1.2.1.10" FT /note="Mb3565c, -, len: 303 aa. Equivalent to Rv3535c, len: FT 303 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 303 aa overlap). Probable acetaldehyde FT dehydrogenase (EC 1.2.1.10), highly similar to many e.g. FT BAB62056|TDNI from Pseudomonas putida (302 aa), FASTA FT scores: opt: 1159, E(): 1.5e-62, (60.45% identity in 301 aa FT overlap); Q9ZI57|NAHO from Pseudomonas stutzeri FT (Pseudomonas perfectomarina) (307 aa) FASTA scores: opt: FT 1151, E(): 4.6e-62, (59.55% identity in 299 aa overlap); FT Q9F9I4|CDOI from Comamonas sp. JS765 (302 aa) FASTA scores: FT opt: 1136, E(): 3.6e-61, (60.15% identity in 301 aa FT overlap); Q51962|NAHO from Pseudomonas putida (307 aa), FT FASTA scores: opt: 1133, E(): 5.6e-61, (58.55% identity in FT 299 aa overlap) (see citation below); FT P77580|MHPF_ECOLI|MHPF|MHPE|B0351 from Escherichia coli FT strain K12 (316 aa), FASTA scores: opt: 1040, E(): 2.2e-55, FT (56.85% identity in 306 aa overlap); etc." FT /db_xref="GOA:Q7TTR4" FT /db_xref="InterPro:IPR000534" FT /db_xref="UniProtKB/TrEMBL:Q7TTR4" FT /protein_id="CAD95751.1" FT /translation="MPSKAKVAIVGSGNISTDLLYKLLRSEWLEPRWMVGIDPESDGLA FT RAAKLGLETTHEGVDWLLAQPDKPDLVFEATSAYVHRDAAPKYAEAGIRAIDLTPAAVG FT PAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVSRIVEVPYAEIVASVASVSAGPGT FT RANIDEFTKTTARGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPTDADREAIAAS FT IHDVVKEVQTYVPGYRLLNEPQFDEPSINSGGQALVTTFVEVEGAGDYLPPYAGNLDIM FT TAAATKVGEEIAKETLVVGGAR" FT CDS complement(166726..167511) FT /transl_table=11 FT /gene="Mb3566c" FT /locus_tag="Mb3566c" FT /product="PROBABLE HYDRATASE" FT /EC_number="4.2.1.-" FT /note="Mb3566c, -, len: 261 aa. Equivalent to Rv3536c, len: FT 261 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 261 aa overlap). Probable hydratase, FT 2-oxo-hepta-3-ene-1,7-dioate hydratase (EC 4.2.1.-) or FT 2-keto-4-pentenoate hydratase (EC 4.2.1.-). Indeed, highly FT similar to many 2-oxo-hepta-3-ene-1,7-dioate hydratases FT e.g. Q9CKS2|HPAH|PM1534 from Pasteurella multocida (267 aa) FT FASTA scores: opt: 743, E(): 1.5e-39, (45.5% identity in FT 266 aa overlap) Q9RZ31|DRA0122 from Deinococcus radiodurans FT (268 aa), FASTA scores: opt: 709, E(): 2e-37, (45.5% FT identity in 266 aa overlap); Q9HWQ4|HPCG|PA4127 from FT Pseudomonas aeruginosa (267 aa), FASTA scores: opt: 703, FT E(): 4.8e-37, (45.1% identity in 266 aa overlap); FT Q46982|HPAH|HPCG from Escherichia colis strain ATCC 11105 FT (267 aa), FASTA scores: opt: 679, E(): 1.6e-35, (41.35% FT identity in 266 aa overlap); etc. But also highly similar FT to many 2-keto-4-pentenoate hydratases FT (2-hydroxypentadienoic acidhydratases) e.g. Q9LAF7|PHED FT from Bacillus thermoglucosidasius (258 aa), FASTA scores: FT opt: 698, E(): 9.7e-37, (42.45% identity in 252 aa FT overlap); Q52442|BPHH from Pseudomonas sp (260 aa) FASTA FT scores: opt: 675, E(): 2.7e-35, (41.4% identity in 251 aa FT overlap); P77608|MHPD_ECOLI|B0350 from Escherichia coli FT strain K12 (269 aa), FASTA scores: opt: 674, E(): 3.2e-35, FT (42.75% identity in 255 aa overlap); Q52038|BPHX1 from FT Pseudomonas pseudoalcaligenes (260 aa), FASTA scores: opt: FT 663, E(): 1.5e-34, (40.6% identity in 251 aa overlap); FT etc." FT /db_xref="GOA:Q7TW96" FT /db_xref="InterPro:IPR011234" FT /db_xref="UniProtKB/TrEMBL:Q7TW96" FT /protein_id="CAD95752.1" FT /translation="MLRDATRDELAADLAQAERSRDPIGQLTAAHPEIDVVDAYEIQLI FT NIRQRVAEGARVVGHKVGLSSPIMQQMMGVDEPDYGHLLDDMQVFEDTPVQASRYLSPR FT VEVEVGFILAADLPGAGCTEDDVLAATEALVPAIELIDTRIKDWQIKICDTIADNASAA FT GFVLGAARVPPADLDVRAIDAKLTRNGEVVAEGRSDAVLGNPATAVAWLAGKVESFGVR FT LRKGDIVLPGSCTFAVEARAGDEFVADFTGLGLVRLSFE" FT CDS 167584..169275 FT /transl_table=11 FT /gene="Mb3567" FT /locus_tag="Mb3567" FT /product="PROBABLE DEHYDROGENASE" FT /EC_number="1.-.-.-" FT /note="Mb3567, -, len: 563 aa. Equivalent to Rv3537, len: FT 563 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 563 aa overlap). Probable dehydrogenase FT (EC 1.-.-.-), similar to many dehydrogenases or FT hypothetical proteins e.g. Q9I1M6|PA2243 HYPOTHETICAL FT PROTEIN from Pseudomonas aeruginosa (577 aa), FASTA scores: FT opt: 984, E(): 1.2e-48, (34.75% identity in 573 aa FT overlap); Q06401|3O1D_COMTE 3-OXOSTEROID 1-DEHYDROGENASE FT from Comamonas testosteroni (Pseudomonas testosteroni) (573 FT aa), FASTA scores: opt: 955, E(): 5.5e-47, (33.05% identity FT in 590 aa overlap); Q9RA02|KSTD1 3-KETOSTEROID FT DEHYDROGENASE from Rhodococcus erythropolis (510 aa), FASTA FT scores: opt: 631, E(): 1.4e-28, (39.15% identity in 557 aa FT overlap); P77815|KSDD 3-KETOSTEROID-1-DEHYDROGENASE from FT Nocardioides simplex (Arthrobacter simplex) (515 aa), FASTA FT scores: opt: 469, E(): 2.4e-19, (35.45% identity in 564 aa FT overlap); etc." FT /db_xref="GOA:Q7TW95" FT /db_xref="HSSP:1D4D" FT /db_xref="InterPro:IPR003953" FT /db_xref="UniProtKB/TrEMBL:Q7TW95" FT /protein_id="CAD95753.1" FT /translation="MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTA FT RSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLK FT HTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLNVVV FT MQQDYVRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVP FT VELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKY FT QRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSP FT GSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAG FT LQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRG FT ESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSII FT DGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR" FT CDS 169277..170137 FT /transl_table=11 FT /gene="Mb3568" FT /locus_tag="Mb3568" FT /product="PROBABLE DEHYDROGENASE" FT /EC_number="1.-.-.-" FT /note="Mb3568, -, len: 286 aa. Equivalent to Rv3538, len: FT 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 286 aa overlap). Probable dehydrogenase FT (EC 1.-.-.-), similar to Q9L009|SCC30.12c PUTATIVE FT DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA FT scores: opt: 842, E(): 3.6e-44, (48.4% identity in 285 aa FT overlap); and similar to C-terminal part of other FT (principally ESTRADIOL 17 FT BETA-DEHYDROGENASES/17-BETA-HYDROXYSTEROID DEHYDROGENASES) FT e.g. P70540 PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE II (SDR FT FAMILY) from Rattus norvegicus (Rat) (735 aa) FASTA scores: FT opt: 622, E(): 1.9e-30, (37.45% identity in 283 aa FT overlap); or P70523|MPF-2 MULTIFUNCTIONAL PROTEIN 2 (SDR FT FAMILY) (beta-oxidation protein displaying 2-enoyl-CoA FT hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity) FT from Rattus norvegicus (Rat) (734 aa), FASTA scores: opt: FT 616, E(): 4.3e-30, (37.1% identity in 283 aa overlap); FT P51659|DHB4_HUMAN|HSD17B4|EDH17B4 ESTRADIOL 17 FT BETA-DEHYDROGENASE (EC 1.1.1.62) from Homo sapiens (Human) FT (736 aa), FASTA scores: opt: 614, E(): 5.7e-30, (35.9% FT identity in 284 aa overlap); FT P97852|DHB4_RAT|HSD17B4|EDH17B4 ESTRADIOL 17 FT BETA-DEHYDROGENASE from Rattus norvegicus (Rat) (735 aa) FT FASTA scores: opt: 613, E(): 6.6e-30, (37.1% identity in FT 283 aa overlap); Q9DBM3|HSD17B4 ESTRADIOL 17 FT BETA-DEHYDROGENASE from Mus musculus (Mouse) (735 aa) FASTA FT scores: opt: 611, E(): 8.7e-30, (36.5% identity in 285 aa FT overlap); etc. Also similar to Q11198|Rv3389c|MTV004.47c FT HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium FT tuberculosis (290 aa), FASTA scores: opt: 609, E(): FT 5.3e-30, (39.65% identity in 285 aa overlap). Note that FT previously known as ufaA2." FT /db_xref="GOA:Q7TW94" FT /db_xref="InterPro:IPR002539" FT /db_xref="UniProtKB/TrEMBL:Q7TW94" FT /protein_id="CAD95754.1" FT /translation="MPIDLDVALGAQLPPVEFSWTSTDVQLYQLGLGAGSDPMNPRELS FT YLADDTPQVLPTFGNVAATFHLTTPPTVQFPGIDIELSKVLHASERVEVPAPLPPSGSA FT RAVTRFTDIWDKGKAAVICSETTATTPDGLLLWTQKRSIYARGEGGFGGKRGPSGSDVA FT PERAPDLQVAMPILPQQALLYRLCGDRNPLHSDPEFAAAAGFPRPILHGLCTYGMTCKA FT IVDALLDSDATAVAGYGARFAGVAYPGETLTVNVWKDGRRLVASVVAPTRDNAVVLSGV FT ELVPA" FT CDS 170274..171713 FT /transl_table=11 FT /gene="PPE63" FT /locus_tag="Mb3569" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3569, PPE63, len: 479 aa. Equivalent to Rv3539, FT len: 479 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 479 aa overlap). Member of the FT Mycobacterium tuberculosis PPE protein family, similar to FT many e.g. O53949|Rv1800|MTV049.22 (655 aa), FASTA scores: FT opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa FT overlap); etc." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/TrEMBL:Q7TW93" FT /protein_id="CAD95755.1" FT /translation="MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAAS FT FESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMALAYEAAFAA FT TVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVASAVG FT ARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPFIGRL FT LAARYAELNTAIGTNWFPGTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEIL FT AATASGQPVTVAGLSMGSMVIDRELAYLAIDPNAPPSSALTFVELAGPERGLAQTYLPV FT GTTIPIAGYTVGNAPESQYNTSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTA FT YAAPQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVD FT AGYSQYAPTAGPYFSHGNLVW" FT CDS complement(171714..172874) FT /transl_table=11 FT /gene="ltp2" FT /locus_tag="Mb3570c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3570c, ltp2, len: 386 aa. Equivalent to Rv3540c, FT len: 386 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 386 aa overlap). Probable ltp2, FT lipid-transfer protein or keto acyl-CoA thiolase (EC FT 2.3.1.16), similar to several e.g. Q9X4X2|DITF DITF PROTEIN FT (hypothetical protein, similar to non-specific FT lipid-transfer protein and 3-ketoacyl-CoA thiolase) from FT Pseudomonas abietaniphila (397 aa), FASTA scores: opt: 665, FT E(): 5.3e-34, (33.4% identity in 392 aa overlap); FT O30255|AF2416 3-KETOACYL-COA THIOLASE (ACAB-12) from FT Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 496, FT E(): 1.6e-23, (30.35% identity in 389 aa overlap); FT O28978|AF1291 3-KETOACYL-COA THIOLASE (ACAB-11) from FT Archaeoglobus fulgidus (392 aa), FASTA scores: opt: 494, FT E(): 2.2e-23, (30.6% identity in 379 aa overlap); FT O26884|MTH793 LIPID-TRANSFER PROTEIN (STEROL OR FT NONSPECIFIC) from Methanobacterium thermoautotrophicum (383 FT aa), FASTA scores: opt: 487, E(): 5.9e-23, (30.4% identity FT in 388 aa overlap); etc." FT /db_xref="GOA:Q7TW92" FT /db_xref="InterPro:IPR002155" FT /db_xref="UniProtKB/TrEMBL:Q7TW92" FT /protein_id="CAD95756.1" FT /translation="MLSGQAAIVGIGATDFSKNSGRSELRLAAEAVLDALADAGLSPTD FT VDGLTTFTMDTNTEIAVARAAGIGELTFFSKIHYGGGAACATVQHAAMAVATGVADVVV FT AYRAFNERSGMRFGQVQTRLTENADSTGVDNSFSYPHGLSTPAAQVAMIARRYMHLSGA FT TSRDFGAVSVADRKHAANNPKAYFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGAVAI FT VVTSAARARDLKQRPVVIEAAAQGCSPDQYTMVSYYRPELDGLPEMGLVGRQLWAQSGL FT TPADVQTAVLYDHFTPFTLIQLEELGFCGKGEAKDFIADGAIEVGGRLPINTHGGQLGE FT AYIHGMNGIAEGVRQLRGTSVNPVAGVEHVLVTAGTGVPTSGLILG" FT CDS complement(172874..173263) FT /transl_table=11 FT /gene="Mb3571c" FT /locus_tag="Mb3571c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3571c, -, len: 129 aa. Equivalent to Rv3541c, len: FT 129 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 129 aa overlap). Hypothetical protein, FT showing some similarity to Q9CBJ7|ML1909 HYPOTHETICAL FT PROTEIN from Mycobacterium leprae (142 aa) FASTA scores: FT opt: 110, E(): 1.2, (27.95% identity in 118 aa overlap); FT and other (see also BLASTP results) e.g. Q9L0M3|SCD82.08 FT HYPOTHETICAL 15.2 KDA PROTEIN from Streptomyces coelicolor FT (142 aa), FASTA scores: opt: 127, E(): 0.086, (27.65% FT identity in 123 aa overlap). Contains PS00075 Dihydrofolate FT reductase signature." FT /db_xref="UniProtKB/TrEMBL:Q7TW91" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95757.1" FT /translation="MTVVGAVLPELKLYGDPTFIVSTALATRDFQDVHHDRDKAVAQGS FT KDIFVNILTDTGLVQRYVTDWAGPSALIKSIGLRLGVPWYAYDTVTFSGEVTAVNDGLI FT TVKVVGRNTLGDHVTATVELSMRDS" FT CDS complement(173260..174195) FT /transl_table=11 FT /gene="Mb3572c" FT /locus_tag="Mb3572c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3572c, -, len: 311 aa. Equivalent to Rv3542c, len: FT 311 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 311 aa overlap). Hypothetical protein, FT showing some similarity to other e.g. Q58947|MJ1552 from FT Methanococcus jannaschii (141 aa) FASTA scores: opt: 177, FT E(): 0.00065, (46.65% identity in 60 aa overlap); FT BAB59276|TVG0142586 from Thermoplasma volcanium (135 aa), FT FASTA scores: opt: 175, E(): 0.00083, (35.65% identity in FT 87 aa overlap); Q9HI85|TA1457 from Thermoplasma acidophilum FT (135 aa), FASTA scores: opt: 162, E(): 0.0052, (31.8% FT identity in 107 aa overlap); etc." FT /db_xref="InterPro:IPR002878" FT /db_xref="UniProtKB/TrEMBL:Q7TW90" FT /protein_id="CAD95758.1" FT /translation="MTGVSDIQEAVAQIKAAGPSKPRLARDPVNQPMINNWVEAIGDRN FT PIYVDDAAARAAGHPGIVAPPAMIQVWTMMGLGGVRPKDDPLGPIIKLFDDAGYIGVVA FT TNCEQTYHRYLLPGEQVSISAELGDVVGPKQTALGEGWFINQHIVWQVGDEDVAEMNWR FT ILKFKPAGSPSSVPDDLDPDAMMRPSSSRDTAFFWDGVKAHELRIQRLADGSLRHPPVP FT AVWQDKSVPINYVVSSGRGTVFSFVVHHAPKVPGRTVPFVIALVELEEGVRMLGELRGA FT DPARVAIGMPVRATYIDFPDWSLYAWEPDE" FT CDS complement(174192..175355) FT /transl_table=11 FT /gene="fadE29" FT /locus_tag="Mb3573c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE29" FT /EC_number="1.3.99.-" FT /note="Mb3573c, fadE29, len: 387 aa. Equivalent to Rv3543c, FT len: 387 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 387 aa overlap). Probable fadE29, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT Q9A8P3|CC1310 from Caulobacter crescentus (404 aa), FASTA FT scores: opt: 624, E(): 9.4e-32, (32.75% identity in 400 aa FT overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 FT aa), FASTA scores: opt: 550, E(): 3.9e-27, (33.7% identity FT in 350 aa overlap); O28976|AF1293 from Archaeoglobus FT fulgidus (384 aa), FASTA scores: opt: 529, E(): 8.1e-26, FT (30.0% identity in 393 aa overlap); etc. Also similar to FT other from Mycobacterium tuberculosis e.g. FT O53549|FADE26|Rv3504|MTV023.11 (400 aa), FASTA scores: opt: FT 1031, E(): 2.8e-57, (46.0% identity in 402 aa overlap). FT COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q7TW89" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TW89" FT /protein_id="CAD95759.1" FT /translation="MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHGPAYRAVI FT RRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLPAVTLQTVGPTLQAHGSE FT LQKKKFLPAILAGEAHFAIGYTEPEAGTDLASLRTTAVRDGDHYIVNGQKVFTTGAHDA FT DYIWLACRTDPNAAKHKGISILIVDTKDPGYSWTPIILADGAHHTNATYYNDVRVPVDM FT LVGKENDGWRLITTQLNNERVMLGPAGRFASIYDRVHAWASVPGGNGVTPIDHDDVKRA FT LGEIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERVQRAGRLAEEIVGKYGNPA FT EPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMIAASGLKVPRVPR" FT CDS complement(175340..176359) FT /transl_table=11 FT /gene="fadE28" FT /locus_tag="Mb3574c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE28" FT /EC_number="1.3.99.-" FT /note="Mb3574c, fadE28, len: 339 aa. Equivalent to Rv3544c, FT len: 339 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 339 aa overlap). Probable fadE28, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FT FASTA scores: opt: 334, E(): 5.1e-13, (27.65% identity in FT 329 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus FT (344 aa), FASTA scores: opt: 278, E(): 1.2e-09, (26.95% FT identity in 319 aa overlap); O29813|AF0436 from FT Archaeoglobus fulgidus (382 aa) FASTA scores: opt: 205, FT E(): 3.5e-05, (24.75% identity in 384 aa overlap); etc. FT Also similar to other from Mycobacterium tuberculosis e.g. FT O53550|FADE27|Rv3505|MTV023.12 (373 aa) FASTA scores: opt: FT 497, E(): 7e-23, (30.3% identity in 343 aa overlap); and to FT P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE FT ACYL-COA DEHYDROGENASE from Mycobacterium leprae (389 aa) FT FASTA scores: opt: 165, E(): 0.0012, (25.2% identity in 345 FT aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:Q7TW88" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TW88" FT /protein_id="CAD95760.1" FT /translation="MDFDPTAEQQAVADVVTSVLERDISWEALVCGGVTALPVPERLGG FT DGVGLFEVGALLTEVGRHGAVTPALATLGLGVVPLLELASAEQQDRFLAGVAKGGVLTA FT ALNEPGAALPDRPATSFVGGRLSGTKVGVGYAEQADWMLVTADNAVVVVSPTADGVRMV FT RTPTSNGSDEYVMTMDGVAVADCDILADVAAHRVNQLALAVMGAYADGLVAGALRLTAD FT YVANRKQFGKPLSTFQTVAAQLAEVYIASRTIDLVAKSVIWRLAEDLDAGDDLGVLGYW FT VTSQAPPAMQICHHLHGGMGMDVTYPMHRYYSTIKDLTRLLGGPSHRLELLGARCSLT" FT CDS complement(176359..177660) FT /transl_table=11 FT /gene="cyp125" FT /locus_tag="Mb3575c" FT /product="PROBABLE CYTOCHROME P450 125 CYP125" FT /EC_number="1.14.-.-" FT /note="Mb3575c, cyp125, len: 433 aa. Equivalent to Rv3545c, FT len: 433 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 433 aa overlap). Probable cyp125, FT cytochrome P-450 (EC 1.14.-.-), similar to others e.g. FT Q59723|LINC|CYP111 from Pseudomonas incognita (406 aa), FT FASTA scores: opt: 831, E(): 8e-45, (34.75% identity in 406 FT aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces FT coelicolor (411 aa), FASTA scores: opt: 694, E(): 3.3e-36, FT (32.35% identity in 417 aa overlap); Q9L465|CYP162A1|NIKQ FT from Streptomyces tendae (396 aa) FASTA scores: opt: 664, FT E(): 2.5e-34, (34.15% identity in 413 aa overlap); FT O08469|CPXY_BACSU|CYPA|CYP107J1 from Bacillus subtilis (410 FT aa), FASTA scores: opt: 579, E(): 5.6e-29, (30.05% identity FT in 366 aa overlap); etc. Also similar to other from FT Mycobacterium tuberculosis e.g. FT Q50696|CYP124|Rv2266|MT2328|MTCY339.44c (428 aa) FASTA FT scores: opt: 1040, E(): 6.1e-58, (40.75% identity in 432 aa FT overlap). BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P63710" FT /db_xref="HSSP:1CPT" FT /db_xref="InterPro:IPR017972" FT /db_xref="UniProtKB/Swiss-Prot:P63710" FT /protein_id="CAD95761.1" FT /translation="MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAE FT LRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKNDI FT AREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGS FT GDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSAELIG FT YAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGM FT MAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMF FT YRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMP FT DLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH" FT CDS 177772..178947 FT /transl_table=11 FT /gene="fadA5" FT /locus_tag="Mb3576" FT /product="PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA5 FT (ACETOACETYL-COA THIOLASE)" FT /EC_number="2.3.1.9" FT /note="Mb3576, fadA5, len: 391 aa. Equivalent to Rv3546, FT len: 391 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 391 aa overlap). Probable fadA5, FT acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many FT e.g. Q9AA29|CC0779 from Caulobacter crescentus (390 aa), FT FASTA scores: opt: 999, E(): 7.1e-54, (43.5% identity in FT 400 aa overlap); Q9K783|BH3487 from Bacillus halodurans FT (393 aa), FASTA scores: opt: 843, E(): 2.6e-44, (37.45% FT identity in 398 aa overlap); Q9RRK9|DR2480 from Deinococcus FT radiodurans (399 aa), FASTA scores: opt: 826, E(): 2.8e-43, FT (38.15% identity in 396 aa overlap); P45369|THIL_CHRVI|PHBA FT from Chromatium vinosum (394 aa) FASTA scores: opt: 790, FT E(): 4.5e-41, (39.4% identity in 401 aa overlap); etc. FT Contains PS00737 Thiolases signature 2. BELONGS TO THE FT THIOLASE FAMILY." FT /db_xref="GOA:Q7TW87" FT /db_xref="HSSP:1AFW" FT /db_xref="InterPro:IPR002155" FT /db_xref="UniProtKB/TrEMBL:Q7TW87" FT /protein_id="CAD95762.1" FT /translation="MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQS FT GLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAGLPEHVGATTVDCQCGSGQQANHLIA FT GLIAAGAIDVGIACGIEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAKRRG FT ITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRE FT TTMAGLGELKPVLEGGIHTAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVG FT AEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFASVVLSWARVHEPDMDRVNVNG FT GAIALGHPVGCTGSRLITTALHELERTDQSLALITMCAGGALSTGTIIERI" FT CDS 179059..179514 FT /transl_table=11 FT /gene="Mb3577" FT /locus_tag="Mb3577" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3577, -, len: 151 aa. Equivalent to Rv3547, len: FT 151 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 151 aa overlap). Conserved hypothetical FT protein, similar to other hypothetical proteins e.g. FT O85698|3SCF60.07 from Streptomyces lividans and FT Streptomyces coelicolor (149 aa), FASTA scores: opt: 353, FT E(): 6.3e-17, (42.55% identity in 134 aa overlap); FT Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa) FASTA FT scores: opt: 290, E(): 2.1e-12, (38.5% identity in 122 aa FT overlap) (similarity in N-terminus for this protein); FT BAB52932|Q988L5|MLL6688 from Rhizobium loti (Mesorhizobium FT loti) (148 aa), FASTA scores: opt: 105, E(): 3, (26.75% FT identity in 86 aa overlap). Also similar to mycobacterial FT hypothetical proteins e.g. Q9ZH81 from M. paratuberculosis FT (144 aa), FASTA scores: opt: 366, E(): 8.2e-18, (43.9% FT identity in 123 aa overlap); and FT Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c from M. FT tuberculosis (148 aa), FASTA scores: opt: 330, E(): FT 2.2e-15, (39.75% identity in 151 aa overlap); etc." FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/TrEMBL:Q7TW86" FT /protein_id="CAD95763.1" FT /translation="MPKSPPRFLNSPLSDFFIKWMSRINTWMYRRNDGEGLGGTFQKIP FT VALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQIKK FT EVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCEP" FT CDS complement(179597..180511) FT /transl_table=11 FT /gene="Mb3578c" FT /locus_tag="Mb3578c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3578c, -, len: 304 aa. Equivalent to Rv3548c, len: FT 304 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 304 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), highly similar to FT various dehydrogenases/reductases (generally belonging to FT the SDR FAMILY) e.g. Q9I4V1|PA1023 from Pseudomonas FT aeruginosa (305 aa), FASTA scores: opt: 446, E(): 1.7e-17, FT (43.75% identity in 256 aa overlap); Q9A6K0|CC2093 from FT Caulobacter crescentus (301 aa) FASTA scores: opt: 437, FT E(): 5.3e-17, (42.8% identity in 257 aa overlap); FT Q9HYH8|PA3427 from Pseudomonas aeruginosa (303 aa), FASTA FT scores: opt: 399, E(): 6.5e-15, (45.5% identity in 257 aa FT overlap); Q9VXJ0|CG3415 from Drosophila melanogaster (Fruit FT fly) (598 aa), FASTA scores: opt: 402, E(): 7.5e-15, (40.7% FT identity in 285 aa overlap); etc. Also highly similar to FT O53547|Rv3502c|MTV023.09c PUTATIVE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE from (317 aa) FASTA scores: opt: FT 739, E(): 1.6e-33, (45.15% identity in 310 aa overlap); and FT other proteins from Mycobacterium tuberculosis. Contains FT PS00061 Short-chain alcohol dehydrogenase family signature. FT BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FT FAMILY." FT /db_xref="GOA:Q7TW85" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TW85" FT /protein_id="CAD95764.1" FT /translation="MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGS FT PASGGSAAQDVVDEILAAGGQAVADGSDISDWDQAANLIQAAVETYGGVDVLVNNAGIV FT RDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTSSGA FT GLQGSVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEVMAKP FT QEGFDAMAPENVSPLVVWLGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDP FT AELGPVVSDLLAKSRPPVPVYGA" FT CDS complement(180534..181313) FT /transl_table=11 FT /gene="Mb3579c" FT /locus_tag="Mb3579c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3579c, -, len: 259 aa. Equivalent to Rv3549c, len: FT 259 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 259 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT dehydrogenases/reductases (generally belong to the SDR FT FAMILY) e.g. Q9UKU3 from Homo sapiens (Human) (270 aa), FT FASTA scores: opt: 451, E(): 4.8e-21, (38.05% identity in FT 247 aa overlap); Q9S274|SCI28.09c from Streptomyces FT coelicolor (234 aa), FASTA scores: opt: 439, E(): 2.4e-20, FT (36.8% identity in 231 aa overlap); Q9PFI6|XF0671 from FT Xylella fastidiosa (247 aa), FASTA scores: opt: 437, E(): FT 3.4e-20, (37.7% identity in 252 aa overlap); etc. Also FT highly similar to O33308|FABG5|Rv2766c|MTV002.31c ALCOHOL FT DEHYDROGENASE (SDR FAMILY) from Mycobacterium tuberculosis FT (260 aa), FASTA scores: opt: 504, E(): 2.3e-24, (38.5% FT identity in 244 aa overlap). Contains PS00061 Short-chain FT alcohol dehydrogenase family signature. BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7TW84" FT /db_xref="HSSP:1Q7B" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TW84" FT /protein_id="CAD95765.1" FT /translation="MTLAEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVIT FT CARRAVDGQPYEFHRCDIRDEDSVKRLVGEIGERHGRLDMLVNNAGGSPYALAAEATHN FT FHRKIVELNVLAPLLVSQHANVLMQAQPNGGSIVNICSVSGRRPTPGTAAYGAAKAGLE FT NLTTTLAVEWAPKVRVNAVVVGMVETERSELFYGDAESIARVAATVPLGRLARPADIGW FT AAAFLASDAASYISGATLEVHGGGEPPPYLGASSANK" FT CDS 181368..182111 FT /transl_table=11 FT /gene="echA20" FT /locus_tag="Mb3580" FT /product="PROBABLE ENOYL-COA HYDRATASE ECHA20 (ENOYL FT HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)" FT /EC_number="4.2.1.17" FT /note="Mb3580, echA20, len: 247 aa. Equivalent to Rv3550, FT len: 247 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 247 aa overlap). Probable echA20, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. FT Q9A7B0|CC1814 from Caulobacter crescentus (275 aa), FASTA FT scores: opt: 488, E(): 3.5e-24, (36.4% identity in 239 aa FT overlap); O84978|PHAA from Pseudomonas putida (293 aa), FT FASTA scores: opt: 383, E(): 2e-17, (33.85% identity in 254 FT aa overlap); BAB48479|Q98LI4|MLL1009 from Rhizobium loti FT (Mesorhizobium loti) (258 aa), FASTA scores: opt: 378, E(): FT 3.8e-17, (21.45% identity in 231 aa overlap); etc. COULD FT BELONG TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY." FT /db_xref="GOA:Q7TW83" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:Q7TW83" FT /protein_id="CAD95766.1" FT /translation="MPITSTTPEPGIVAVTVDYPPVNAIPSKAWFDLADAVTAAGANSD FT TRAVILRAEGRGFNAGVDIKEMQRTEGFTALIDANRGCFAAFRAVYECAVPVIAAVNGF FT CVGGGIGLVGNSDVIVASEDATFGLPEVERGALGAATHLSRLVPQHLMRRLFFTAATVD FT AATLQHFGSVHEVVSRDQLDEAALRVARDIAAKDTRVIRAAKEALNFIDVQRVNASYRM FT EQGFTFELNLAGVADEHRDAFVKKS" FT CDS 182111..182989 FT /transl_table=11 FT /gene="Mb3581" FT /locus_tag="Mb3581" FT /product="POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT)" FT /EC_number="2.8.3.-" FT /note="Mb3581, -, len: 292 aa. Equivalent to Rv3551, len: FT 292 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 292 aa overlap). Possible FT CoA-transferase, alpha subunit (EC 2.8.3.-), similar in FT part to other CoA-transferases e.g. Q59111|GCTA_ACIFE|GCTA FT GLUTACONATE COA-TRANSFERASE SUBUNIT A (EC 2.8.3.12) (GCT FT LARGE SUBUNIT) from Acidaminococcus fermentans (319 aa) FT FASTA scores: opt: 247, E(): 6.3e-09, (27.35% identity in FT 307 aa overlap); Q9XD83|PCAI from Streptomyces sp. 2065 FT (251 aa), FASTA scores: opt: 222, E(): 2.3e-07, (27.55% FT identity in 243 aa overlap); BAB50895|MLL4183 from FT Rhizobium loti (Mesorhizobium loti) (285 aa), FASTA scores: FT opt: 206, E(): 2.8e-06, (27.4% identity in 281 aa overlap); FT etc. Also some similarity with FT O06167|SCOA_MYCTU|RVv504c|MT2579|MTCY07A7.10c PROBABLE FT SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE SUBUNIT A FT from Mycobacterium tuberculosis (248 aa), FASTA scores: FT opt: 210, E(): 1.4e-06, (25.5% identity in 247 aa overlap). FT BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT A FT FAMILY. Note that this putative protein may combine with FT the putative protein encoded by the downstream ORF Rv3552 FT to form a CoA-transferase that comprises two subunits." FT /db_xref="GOA:Q7TW82" FT /db_xref="InterPro:IPR004165" FT /db_xref="UniProtKB/TrEMBL:Q7TW82" FT /protein_id="CAD95767.1" FT /translation="MPDKRTSLDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDVT FT DLTVVTYGGPDLGLLCSAGKVKRVYYGFVSLDSPPFYDPWFAHARTSGAIEAREMDEGM FT LRCGLQAAAQRLPFLPIRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPALRLD FT AAFAHLNLGDSHGNAAYTGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQALLV FT NRMMVDAIVEAPGGAHFTTAAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSGTEADY FT QAAVHNFGASR" FT CDS 182986..183738 FT /transl_table=11 FT /gene="Mb3582" FT /locus_tag="Mb3582" FT /product="POSSIBLE COA-TRANSFERASE (BETA SUBUNIT)" FT /EC_number="2.8.3.-" FT /note="Mb3582, -, len: 250 aa. Equivalent to Rv3552, len: FT 250 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 250 aa overlap). Possible FT CoA-transferase, beta subunit (EC 2.8.3.-), similar in part FT to other CoA-transferases e.g. Q9I6R1|PA0227 from FT Pseudomonas aeruginosa (260 aa), FASTA scores: opt: 233, FT E(): 8.6e-08, (24.8% identity in 238 aa overlap); FT BAB50894|MLL4181 from Rhizobium loti (Mesorhizobium loti) FT (264 aa), FASTA scores: opt: 210, E(): 2.6e-06, (24.15% FT identity in 203 aa overlap); and AAK41345|Q97Z51|GCTB from FT Sulfolobus solfataricus (245 aa), FASTA scores: opt: 122, FT E(): 1.1, (25.5% identity in 243 aa overlap). POSSIBLY FT BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT B FT FAMILY. Note that this putative protein may combine with FT the putative protein encoded by the upstream ORF Rv3551 to FT form a CoA-transferase that comprises two subunits." FT /db_xref="GOA:P63653" FT /db_xref="UniProtKB/Swiss-Prot:P63653" FT /protein_id="CAD95768.1" FT /translation="MSTRAEVCAVACAELFRDAGEIMISPMTNMASVGARLARLTFAPD FT ILLTDGEAQLLADTPALGKTGAPNRIEGWMPFGRVFETLAWGRRHVVMGANQVDRYGNQ FT NISAFGPLQRPTRQMFGVRGSPGNTINHATSYWVGNHCKRVFVEAVDVVSGIGYDKVDP FT DNPAFRFVNVYRVVSNLGVFDFGGPDHSMRAVSLHPGVTPGDVRDATSFEVHDLDAAEQ FT TRLPTDDELHLIRAVIDPKSLRDREIRS" FT CDS 183836..184903 FT /transl_table=11 FT /gene="Mb3583" FT /locus_tag="Mb3583" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3583, -, len: 355 aa. Equivalent to Rv3553, len: FT 355 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 355 aa overlap). Possible FT oxidoreductase (EC 1.-.-.-), highly similar (except in FT C-terminus) to Q9A327|CC3379 HYPOTHETICAL PROTEIN from FT Caulobacter crescentus (321 aa), FASTA scores: opt: 639, FT E(): 4.6e-29, (46.35% identity in 248 aa overlap); and FT Q9WZQ7|TM0800 CONSERVED HYPOTHETICAL PROTEIN from FT Thermotoga maritima (314 aa), FASTA scores: opt: 622, E(): FT 4.1e-28, (37.95% identity in 340 aa overlap). Also similar FT to two TRANS-2-ENOYL-ACP REDUCTASES; Q99YD4|FABK|SPY1751 FT from Streptococcus pyogenes (323 aa), FASTA scores: opt: FT 604, E(): 4.4e-27, (33.25% identity in 346 aa overlap); and FT Q9FBC5|FABK from Streptococcus pneumoniae (324 aa), FASTA FT scores: opt: 553, E(): 3.3e-24, (32.1% identity in 346 aa FT overlap); and similar with several 2-NITROPROPANE FT DIOXYGENASES, e.g. Q9F7P8 from uncultured proteobacterium FT EBAC31A08 (322 aa), FASTA scores: opt: 505, E(): 1.7e-21, FT (33.6% identity in 348 aa overlap); Q9FMG0 (alias AAK44141) FT from Arabidopsis thaliana (Mouse-ear cress) (333 aa), FASTA FT scores: opt: 489, E(): 1.4e-20, (33.15% identity in 341 aa FT overlap); O28109|AF2173 (NCD2) from Archaeoglobus fulgidus FT (274 aa), FASTA scores: opt: 456, E(): 8.9e-19, (36.3% FT identity in 237 aa overlap); etc." FT /db_xref="GOA:Q7TW81" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:Q7TW81" FT /protein_id="CAD95769.1" FT /translation="MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILAS FT ATMTLDELAAAITKVKAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFALAPKQQL FT IARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGGHTGPVATTLLLPSVLDAV FT AGTGIPVIAAGGFFDGRGLAAALCYGAAGVAMGTRFLLTSDSTVPDAVKRRYLQAGLDG FT TVVTTRVDGMPHRVLRTELVEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLT FT MRHGKELTWSQVLMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIV FT LDAITHLQTASALVE" FT CDS 184900..186957 FT /transl_table=11 FT /gene="fdxB" FT /locus_tag="Mb3584" FT /product="POSSIBLE ELECTRON TRANSFER PROTEIN FDXB" FT /EC_number="1.-.-.-" FT /note="Mb3584, fdxB, len: 685 aa. Equivalent to Rv3554, FT len: 685 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 685 aa overlap). Possible fdxB, FT two-domain protein, with ferredoxin reductase electron FT transfer component in C-terminal part (EC 1.-.-.-) and FT unknown function in N-terminal part. Indeed, N-terminal end FT is similar to O85832 HYPOTHETICAL 36.1 KDA PROTEIN from FT Sphingomonas aromaticivorans strain F199 (catabolic plasmid FT pNL1) (309 aa), FASTA scores: opt: 615, E(): 2.5e-30, FT (33.1% identity in 311 aa overlap); and P73428|SLL1468 FT HYPOTHETICAL 36.2 KDA PROTEIN from Synechocystis sp. strain FT PCC 6803 (312 aa), FASTA scores: opt: 317, E(): 4.5e-12, FT (30.2% identity in 268 aa overlap). And C-terminal end is FT similar to Q9F9U6|PAAE protein involved in aerobic FT phenylacetate metabolism from Azoarcus evansii (360 aa), FT FASTA scores: opt: 935, E(): 7e-50, (43.85% identity in 351 FT aa overlap); CAC44653|PAAE|SCBAC17A6.08 PUTATIVE FT PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from FT Streptomyces coelicolor (368 aa), FASTA scores: opt: 93, FT E(): 9.5e-50, (41.95% identity in 372 aa overlap); FT Q9FA57|PACI FERREDOXIN from Azoarcus evansii (360 aa), FT FASTA scores: opt: 925, E(): 2.9e-49, (43.3% identity in FT 351 aa overlap); P76081|PAAE_ECOLI|B1392 PROBABLE FT PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from FT Escherichia coli strains K12 and W (356 aa), FASTA scores: FT opt: 910, E(): 2.4e-48, (43.05% identity in 353 aa FT overlap); Q9APJ6|PAAE ELECTRON TRANSFER PROTEIN (FRAGMENT) FT from Hyphomicrobium chloromethanicum (241 aa), FASTA FT scores: opt: 404, E(): 1.7e-17, (35.45% identity in 234 aa FT overlap); BAB51608|MLL5100 FERREDOXIN from Rhizobium loti FT (Mesorhizobium loti) (365 aa), FASTA scores: opt: 316, E(): FT 5.8e-12, (28.95% identity in 349 aa overlap); etc. FT C-terminus also similar to P96853|Rv3571|MTCY06G11.18 FT PUTATIVE ELECTRON TRANSFER PROTEIN from Mycobacterium FT tuberculosis (358 aa), FASTA scores: opt: 450, E(): FT 3.6e-20, (32.95% identity in 358 aa overlap). Contains FT PS00197 2Fe-2S ferredoxins, iron-sulfur binding region FT signature. BELONGS TO THE 2FE2S PLANT-TYPE FERREDOXIN FT FAMILY. COFACTOR: BINDS A 2FE-2S CLUSTER (BY SIMILARITY)." FT /db_xref="GOA:Q7TW80" FT /db_xref="HSSP:1J7A" FT /db_xref="InterPro:IPR001041" FT /db_xref="UniProtKB/TrEMBL:Q7TW80" FT /protein_id="CAD95770.1" FT /translation="MTDACQAEYAIAAMSTVEMDQAAPESAAHHPLPDPGESVPRLALP FT TIGIFLATLTAFVGSTTAYISGWIPFWVTIPVNAAVTFVMFTVVHDASHYAISSIRWVN FT GLFGRLAWLFVGPVVAFPAFGYIHIQHHRHSNDDEQDPDTFASHGSLWVLPLRWSMVEY FT FYIKYYLPRGRSRPVIEVAETLVMMTLFLTGLIVAIVTGNFWTLAIVFLIPQRIGLTVL FT AWWFDWLPHHGLEDTQRSNRYRATRNRVGAEWLFTPVLLSQNYHLVHHLHPSVPFYRYL FT RTWRRNEEAYLERNAAISTVFGQQLNPDEYRQWKELNGRLARLLPVRMPARSSSPHAVL FT HRIPVASVDPITADATLVTFAVPEALRDAFRFEPGQHVTVRTDLGGQGIRRNYSICAPA FT TRAQLRIAVKHIPGGAFSTFVANELKAGDVLELMTPTGRFGTPLDPLHRKHYVGLVAGS FT GITPVLSILATTLEIETESRFTLIYGNRTKESTMFRAELDRLESRYADRLEILHVLSSE FT PLHTPELRGRIDRDKLTRWLTSTLRPAGVDEWFICGPLAMATAVRETLIEHGVDSERIH FT LELFYGFDTPPATRPSYAGATVTFTLSGQRAIFDLVPGDSILEGALGLRSDAPYACMGG FT ACGTCRAKLIEGNVEMDHNFALRKAELDAGYILTCQSHPTTPFVAVDYDA" FT CDS complement(187045..187914) FT /transl_table=11 FT /gene="Mb3585c" FT /locus_tag="Mb3585c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3585c, -, len: 289 aa. Equivalent to Rv3555c, len: FT 289 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 289 aa overlap). Hypothetical protein, FT highly similar to others from Mycobacterium tuberculosis FT e.g. O53562|AL022022|Rv3517|MTV023.24 (279 aa), FASTA FT scores: opt: 874, E(): 8.3e-48, (49.45% identity in 275 aa FT overlap); P71763|Rv1482c|MTCY277.03c (339 aa), FASTA FT scores: opt: 755, E(): 3e-40, (45.75% identity in 260 aa FT overlap); O69681|Rv3714c|MTV025.062c (296 aa), FASTA FT scores: opt: 733, E(): 6.4e-39, (44.1% identity in 281 aa FT overlap); etc. Also highly similar to other mycobacterial FT hypothetical proteins e.g. O07396|MAV346 from M. avium (346 FT aa), FASTA scores: opt: 714, E(): 1.1e-37, (44.6% identity FT in 260 aa overlap); and Q50134|U650AG|MLCB57.67c from FT Mycobacterium leprae (75 aa), FASTA scores: opt: 130, E(): FT 0.17, (35.1% identity in 57 aa overlap) (only partial FT homology with this protein). Shows some similarity to FT P52392|NHSR_STRAS PUTATIVE NOSIHEPTIDE RESISTANCE FT REGULATORY PROTEIN (ORF699) from Streptomyces actuosus (233 FT aa), FASTA scores: opt: 120, E(): 1.9, (25.25% identity in FT 194 aa overlap)." FT /db_xref="GOA:Q7TW79" FT /db_xref="UniProtKB/TrEMBL:Q7TW79" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95771.1" FT /translation="MDELPWPVLGSEVLAAKAIPERAMRQLYEPVYPGVYAPAGVELTA FT RQRAHAAWLWSRRRAVVAGNSAAALLGAKWVNPALDAELVHANRKPPPRIVVHTDRLAP FT HETVAVDGVAVTTPARTAFDIGRRTPSRLQAVQRLDALANSTDVKVADVQAVIAEHTGA FT RGLVRLRAVLPLIDGGAESPQETWTRLVLIDAGLPKPQTQIRVFDDYGDFVARIDLGYE FT QLRVGVEYDGPQHWTDPAQRARDIERSTALLDLGWTIIRVTSELLRYRRGTFVGRVDAA FT MRAAGWRP" FT CDS complement(188019..189179) FT /transl_table=11 FT /gene="fadA6" FT /locus_tag="Mb3586c" FT /product="PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA6 FT (ACETOACETYL-COA THIOLASE)" FT /EC_number="2.3.1.9" FT /note="Mb3586c, fadA6, len: 386 aa. Equivalent to Rv3556c, FT len: 386 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 386 aa overlap). Probable fadA6, FT acetyl-CoA acetyltransferase (EC 2.3.1.9), similar to many FT e.g. Q9K409|2SCG61.06c from Streptomyces coelicolor (389 FT aa), FASTA scores: opt: 1091, E(): 2.9e-58, (48.1% identity FT in 399 aa overlap); Q9AAT4|CC0510 from Caulobacter FT crescentus (391 aa), FASTA scores: opt: 902, E(): 6.6e-47, FT (40.25% identity in 395 aa overlap); P45359|THL_CLOAB from FT Clostridium acetobutylicum (392 aa), FASTA scores: opt: FT 872, E(): 4.2e-45, (37.9% identity in 396 aa overlap); FT Q9I2A8|ATOB|PA2001 from Pseudomonas aeruginosa (393 aa), FT FASTA scores: opt: 872, E(): 4.2e-45, (41.3% identity in FT 397 aa overlap); etc. Contains PS00737 Thiolases signature FT 2. BELONGS TO THE THIOLASE FAMILY." FT /db_xref="GOA:Q7TW78" FT /db_xref="HSSP:1AFW" FT /db_xref="InterPro:IPR002155" FT /db_xref="UniProtKB/TrEMBL:Q7TW78" FT /protein_id="CAD95772.1" FT /translation="MTEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDIDP FT AAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIM FT SGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGSEL FT IAEKWNLSREEMERYSLTSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRESSLEK FT MAGLQPLVEGGRLTAAMASQISDGASAVLLASERAVKDHGLRPRARIHHISARAADPVF FT MLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVMAWLKEIKADPAKVNPNGGAIAL FT GHPLGATGAKLFTTMLGELERIGGRYGLQTMCEGGGTANVTIIERL" FT CDS complement(189244..189846) FT /transl_table=11 FT /gene="Mb3587c" FT /locus_tag="Mb3587c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /note="Mb3587c, -, len: 200 aa. Equivalent to Rv3557c, len: FT 200 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 200 aa overlap). Probable FT transcriptional regulator, tetR family, similar to other FT e.g. Q9RRV9|DR2376 from Deinococcus radiodurans (197 aa) FT FASTA scores: opt: 326, E(): 2.3e-14, (31.2% identity in FT 189 aa overlap); Q9HZW2|PA2885 from Pseudomonas aeruginosa FT (198 aa), FASTA scores: opt: 308, E(): 3.5e-13, (31.55% FT identity in 187 aa overlap); Q9RFR4 from Pseudomonas FT fluorescens (207 aa), FASTA scores: opt: 291, E(): 4.7e-12, FT (29.75% identity in 195 aa overlap); Q9K8P5|BH2958 from FT Bacillus halodurans (215 aa), FASTA scores: opt: 271, E(): FT 9.9e-11, (23.95% identity in 192 aa overlap); etc. Also FT similar to proteins from Mycobacterium tuberculosis e.g. FT O53641|Rv0158|MTV032.01 (214 aa), FASTA scores: opt: 232, FT E(): 3.5e-08, (25.5% identity in 192 aa overlap); and FT O06169|Rv2506|MTCY07A7.12 (215 aa), FASTA scores: opt: 215, FT E(): 4.5e-07, (35.15% identity in 148 aa overlap); etc. FT SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL FT REGULATORS." FT /db_xref="GOA:Q7TW77" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7TW77" FT /protein_id="CAD95773.1" FT /translation="MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSG FT SLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTANPLERLQGLFMASFEAIEHHHAQ FT VVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRD FT TTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV" FT CDS 190195..191853 FT /transl_table=11 FT /gene="PPE64" FT /locus_tag="Mb3588" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3588, PPE64, len: 552 aa. Equivalent to Rv3558, FT len: 552 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 552 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, similar to many e.g. P71868|Rv3533c|MTCY03C7.23 FT (582 aa), FASTA scores: opt: 1908, E(): 1.7e-83, (58.5% FT identity in 583 aa overlap)." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7TW76" FT /protein_id="CAD95774.1" FT /translation="MAHFSVLPPEINSLRMYLGAGSAPMLQAAAAWDGLAAELGTAASS FT FSSVTTGLTGQAWQGPASAAMAAAAAPYAGFLTTASAQAQLAAGQAKAVASVFEAAKAA FT IVPPAAVAANREAFLALIRSNWLGLNAPWIAAVESLYEEYWAADVAAMTGYHAGASQAA FT AQLPLPAGLQQFLNTLPNLGIGNQGNANLGGGNTGSGNIGNGNKGSSNLGGGNIGNNNI FT GSGNRGSDNFGAGNVGTGNIGFGNQGPIDVNLLATPGQNNVGLGNIGNNNMGFGNTGDA FT NTGGGNTGNGNIGGGNTGNNNFGFGNTGNNNIGIGLTGNNQMGINLAGLLNSGSGNIGI FT GNSGTNNIGLFNSGSGNIGVFNTGANTLVPGDLNNLGVGNSGNANIGFGNAGVLNTGFG FT NASILNTGLGNAGELNTGFGNAGFVNTGFDNSGNVNTGNGNSGNINTGSWNAGNVNTGF FT GIITDSGLTNSGFGNTGTDVSGFFNTPTGPLAVDVSGFFNTASGGTVINGQTSGIGNIG FT VPGTLFGSVRSGLNTGLFNMGTAISGLFNLRQLLG" FT CDS complement(191862..192650) FT /transl_table=11 FT /gene="Mb3589c" FT /locus_tag="Mb3589c" FT /product="PUTATIVE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3589c, -, len: 262 aa. Equivalent to Rv3559c, len: FT 262 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 262 aa overlap). Putative oxidoreductase FT (EC 1.-.-.-), similar to various oxidoreductases e.g. FT Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE (SDR FT FAMILY) from Streptomyces antibioticus (273 aa), FASTA FT scores: opt: 510, E(): 2.8e-24, (40.15% identity in 249 aa FT overlap);Q9L2C9|SC7A8.29 PUTATIVE DEHYDROGENASE from FT Streptomyces coelicolor (255 aa), FASTA scores: opt: 500, FT E(): 1.1e-23, (41.4% identity in 239 aa overlap); FT Q9HQ41|FABG|VNG1341G 3-OXOACYL-[ACYL-CARRIER-PROTEIN] FT REDUCTASE from Halobacterium sp. strain NRC-1 (255 aa) FT FASTA scores: opt: 500, E(): 1.1e-23, (40.0% identity in FT 250 aa overlap); etc. Also similar to oxidoreductases from FT Mycobacterium tuberculosis eg FT Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE FT OXIDOREDUCTASE (247 aa), FASTA scores: opt: 497, E(): FT 1.6e-23, (39.2% identity in 245 aa overlap)." FT /db_xref="GOA:Q7TW75" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TW75" FT /protein_id="CAD95775.1" FT /translation="MNLSVAPKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGAD FT VVISDHHERRLGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMGRLDVLVNN FT AGLGGQTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAPHGGVIVNNASVLGWRA FT QHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSIARHKFLDKTASAELLDRLVA FT GEAFGRAAEPWEVAATIAFLASDYSSYLTGEVISVSCQHP" FT CDS complement(192647..193804) FT /transl_table=11 FT /gene="fadE30" FT /locus_tag="Mb3590c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE30" FT /EC_number="1.3.99.-" FT /note="Mb3590c, fadE30, len: 385 aa. Equivalent to Rv3560c, FT len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 385 aa overlap). Probable fadE30, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA FT scores: opt: 845, E(): 1.6e-47, (39.2% identity in 388 aa FT overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407 FT aa), FASTA scores: opt: 734, E(): 2.8e-40, (35.5% identity FT in 386 aa overlap); Q9RJX2|SCF37.29c from Streptomyces FT coelicolor (393 aa), FASTA scores: opt: 656, E(): 3.2e-35, FT (37.9% identity in 351 aa overlap); etc. Also similar to FT acyl-CoA dehydrogenases from Mycobacterium tuberculosis FT e.g. P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FASTA FT scores: opt: 939, E(): 1.4e-53, (43.8% identity in 404 aa FT overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:Q7TW74" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TW74" FT /protein_id="CAD95776.1" FT /translation="MQDVEEFRAQVRGWLADNLAGEFAALKGLGGPGREHEAFEERRAW FT NQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARADAPDKVNHFGEELLGPTLIAF FT GTPQQQRRFLPRIRDVTELWCQGYSEPGAGSDLASVATTAELDGDQWVINGQKVWTSLA FT HLSQWCFVLARTEKGSQRHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTD FT ADLVVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADDPLIRER FT LTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWANWHRNLGELAMDVIGKPGMTM FT PDGEFDEWQRLYLFTRADTIYGGSNEIQRNIIAERVLGLPREAKG" FT CDS 193852..195375 FT /transl_table=11 FT /gene="fadD3" FT /locus_tag="Mb3591" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD3 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb3591, fadD3, len: 507 aa. Equivalent to Rv3561, FT len: 507 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 507 aa overlap). Probable fadD3, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT substrate-CoA symthetases/ligases e.g. Q9KBC2|BH2006 FT LONG-CHAIN ACYL-COA SYNTHETASE from Bacillus halodurans FT (513 aa), FASTA scores: opt: 821, E(): 1.6e-43, (32.9% FT identity in 517 aa overlap); Q9EY88|FCS FERULOYL-COA FT SYNTHETASE from Amycolatopsis sp. HR167 (491 aa) FASTA FT scores: opt: 767, E(): 3.5e-40, (37.65% identity in 502 aa FT overlap); Q9ZIP5|MATB MALONYL CoA SYNTHETASE from Rhizobium FT leguminosarum (504 aa), FASTA scores: opt: 758, E(): FT 1.3e-39, (33.7% identity in 472 aa overlap); FT Q9CD27|FADD2|ML2546 ACYL-COA SYNTHASE from Mycobacterium FT leprae (548 aa), FASTA scores: opt: 700, E(): 5.6e-36, FT (31.85% identity in 515 aa overlap); FT P29212|LCFA_ECOLI|FADD|OLDD|B1805 FT LONG-CHAIN-FATTY-ACID--COA LIGASE from Escherichia coli FT strain K12 (561 aa), FASTA scores: opt: 532, E(): 6.3e-28, FT (30.0% identity in 533 aa overlap); etc. Also similar to FT other from Mycobacterium tuberculosis eg FT O53306|FADD13|Rv3089|MTV013.10 (503 aa), FASTA scores: opt: FT 819, E(): 2.1e-43, (35.1% identity in 490 aa overlap). FT Contains PS00455 Putative AMP-binding domain signature." FT /db_xref="GOA:Q7TW73" FT /db_xref="HSSP:1BA3" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TW73" FT /protein_id="CAD95777.1" FT /translation="MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAA FT AALIALGVEPADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGA FT PVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARA FT AAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHN FT FGYKAGILACLQTGATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDF FT DLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVAT FT TCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAG FT NLRINDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARP FT GTGLDEASVIAYTREHLANFKTPRSVRFVDVLPRNAAGKVSKPQLRELG" FT CDS 195376..196509 FT /transl_table=11 FT /gene="fadE31" FT /locus_tag="Mb3592" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE31" FT /EC_number="1.3.99.-" FT /note="Mb3592, fadE31, len: 377 aa. Equivalent to Rv3562, FT len: 377 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 377 aa overlap). Probable fadE31, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa), FT FASTA scores: opt: 657, E(): 1.7e-34, (36.45% identity in FT 351 aa overlap); Q9A5G9|CC2478 from Caulobacter crescentus FT (407 aa), FASTA scores: opt: 653, E(): 3.2e-34, (33.95% FT identity in 392 aa overlap); Q9EX72|MLHC from Rhodococcus FT erythropolis (324 aa) FASTA scores: opt: 631, E(): 6.5e-33, FT (36.95% identity in 330 aa overlap); P45867|ACDA_BACSU|ACD FT from Bacillus subtilis (379 aa), FASTA scores: opt: 347, FT E(): 1e-15, (28.6% identity in 385 aa overlap); etc. Also FT similar to other from Mycobacterium tuberculosis e.g. FT P96842|FADE30|Rv3560c|MTCY06G11.07c (385 aa), FASTA scores: FT opt: 843, E(): 2.3e-46, (38.95% identity in 380 aa FT overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:Q7TW72" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TW72" FT /protein_id="CAD95778.1" FT /translation="MDLNFDDETLAFQAEVREFLAANAASIPTKSYDNAEGFAQHRYWD FT RVLFDAGLSVITWPAKYGGRDAPLLHWIVFEEEYFRAGAPGRASANGTSMLAPTLFAHG FT TAEQLDRILPKMASGEQIWAQAWSEPESGSDLASLRSTASKVDGGWLLNGQKIWSSRAP FT FADMGFGLFRSDPAVERHRGLTYFMFDLKAKGVTVRPIAQLGGDTGFGEIFLDDVFVPD FT RDVIGAPNDGWRAAMSTSSNERGMSLRSPARFLASAERLVQLWKDRGSPPEFADRVADA FT WIKAQAYRLQTFGTVTRLAAGGELGAESSVTKVFWSELDVHLHQTALDLRGADGELAGP FT WTEGLLFALGGPIYAGTNEIQRNIIAERLLGLPREKT" FT CDS 196506..197465 FT /transl_table=11 FT /gene="fadE32" FT /locus_tag="Mb3593" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE32" FT /EC_number="1.3.99.-" FT /note="Mb3593, fadE32, len: 319 aa. Equivalent to Rv3563, FT len: 319 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 319 aa overlap). Probable fadE32, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA FT scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa FT overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor FT (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4% FT identity in 349 aa overlap); Q9A5G8|CC2479 from Caulobacter FT crescentus (344 aa), FASTA scores: opt: 285, E(): 4.1e-10, FT (30.4% identity in 329 aa overlap); P45857|ACDB_BACSU|MMGC FT from Bacillus subtilis (379 aa), FASTA scores: opt: 230, FT E(): 1.1e-07, (25.5% identity in 357 aa overlap); etc. Also FT similar to other from Mycobacterium tuberculosis eg FT P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa), FASTA scores: FT opt: 478, E(): 7.6e-22, (32.9% identity in 292 aa overlap). FT COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q7TW71" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TW71" FT /protein_id="CAD95779.1" FT /translation="MTMEFALNEQQRDFAASIDAALGAADLPGVVRAWAAGDVAPGRKV FT WQQLANLGVTALGVAEKFDGLGASPVDLVVALERLGRWCVPGPVTESIAVAPILLAHDD FT RAERSHGLASGELIATVAMPPRVPRAVDADTAGLVLLAGDGSVTEGTPGDCHRSVDPSR FT RLYEVAASGQAWRAPKDVVARAYEFGALATAAQLVGAGQALLEAAVNYAKQRTQFGRAI FT GSYQAIKHKLADVHIAIELACPLVYGAAVSLEPRDVSAAKAAASEAALLAARSALQTHG FT AIGFTCEHDLSLWLLRVQALHSAWGTPQEHRRRVLEAL" FT CDS 197462..198418 FT /transl_table=11 FT /gene="fadE33" FT /locus_tag="Mb3594" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE33" FT /EC_number="1.3.99.-" FT /note="Mb3594, fadE33, len: 318 aa. Equivalent to Rv3564, FT len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 318 aa overlap). Probable fadE33, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to others FT e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FT FASTA scores: opt: 373, E(): 1.9e-15, (34.3% identity in FT 338 aa overlap); Q9I4V4|PA1020 from Pseudomonas aeruginosa FT (370 aa), FASTA scores: opt: 277, E(): 1.4e-09, (31.95% FT identity in 335 aa overlap); Q9X7Y6|SC6A5.40c from FT Streptomyces coelicolor (395 aa), FASTA scores: opt: 273, FT E(): 2.5e-09, (30.1% identity in 352 aa overlap); FT P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FT FASTA scores: opt: 478, E(): 7.9e-22, (32.9% identity in FT 292 aa overlap); etc. Also similar to others from FT Mycobacterium tuberculosis e.g. FT P96845|FADE32|Rv3563|MTCY06G11.10 (319 aa), FASTA scores: FT opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa overlap). FT COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q7TW70" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TW70" FT /protein_id="CAD95780.1" FT /translation="MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDRGYDESLWRLL FT CEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLGTTLAELALLAAAKPDA FT QALTELAQGSAIGALVLDPDYVVNGDIADIVVAATSGQLTRWTRFSAQPVATMDPTRRL FT ARLQSEETEPLCPDPGIADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQA FT LKHRMADLYVTIAAARAVVADACHAPTPTNAATARLAASEALSTAAAEGIQLHGGIAIT FT WEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP" FT CDS 198415..199581 FT /transl_table=11 FT /gene="aspB" FT /locus_tag="Mb3595" FT /product="POSSIBLE ASPARTATE AMINOTRANSFERASE ASPB FT (TRANSAMINASE A) (ASPAT) (GLUTAMIC--OXALOACETIC FT TRANSAMINASE) (GLUTAMIC--ASPARTIC TRANSAMINASE)" FT /EC_number="2.6.1.1" FT /note="Mb3595, aspB, len: 388 aa. Equivalent to Rv3565, FT len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 388 aa overlap). Possible aspB, FT aspartate aminotransferase (EC 2.6.1.1), similar to many FT e.g. Q9A5J2|CC2455 AMINOTRANSFERASE CLASS I from FT Caulobacter crescentus (381 aa), FASTA scores: opt: 1112, FT E(): 1e-61, (45.85% identity in 384 aa overlap); FT Q9HV76|PA4722 PROBABLE AMINOTRANSFERASE from Pseudomonas FT aeruginosa (390 aa), FASTA scores: opt: 863, E(): 3.1e-46, FT (37.2% identity in 390 aa overlap); Q9RWP3|DR0623 ASPARTATE FT AMINOTRANSFERASE from Deinococcus radiodurans (388 aa), FT FASTA scores: opt: 713, E(): 6.3e-37, (35.5% identity in FT 383 aa overlap); Q9HQK2|ASPC2|VNG1121G ASPARTATE FT AMINOTRANSFERASE from Halobacterium sp. strain NRC-1 (391 FT aa), FASTA scores: opt: 710, E(): 9.8e-37, (34.45% identity FT in 380 aa overlap); O33822|AAT_THEAQ|ASPC ASPARTATE FT AMINOTRANSFERASE from Thermus aquaticus (383 aa), FASTA FT scores: opt: 695, E(): 8.2e-36, (35.1% identity in 376 aa FT overlap); etc. Contains PS00105 Aminotransferases class-I FT pyridoxal-phosphate attachment site. BELONGS TO CLASS-I OF FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: FT PYRIDOXAL PHOSPHATE (BY SIMILARITY)." FT /db_xref="GOA:Q7TW69" FT /db_xref="HSSP:5BJ4" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/TrEMBL:Q7TW69" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95781.1" FT /translation="MTDRVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGA FT PEPVRAAAAAALHLNQLGYSVALGIPELRDAIAADYQRRHGITVEPDAVVITTGSSGGF FT LLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQMLAEIDPP FT LRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQGAPQTSCAWQT FT SRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTP FT EATAEADGNLASYAINRSLLLDGLRRIGIDRLAPTDGAFYVYADVSDFTSDSLAFCSKL FT LADTGVAIAPGIDFDTARGGSFVRISFAGPSGDIEEALRRIGSWLPSQ" FT CDS complement(199546..200397) FT /transl_table=11 FT /gene="nat" FT /locus_tag="Mb3596c" FT /product="ARYLAMINE N-ACETYLTRANSFERASE NAT (ARYLAMINE FT ACETYLASE)" FT /EC_number="2.3.1.5" FT /note="Mb3596c, nat, len: 283 aa. Equivalent to Rv3566c, FT len: 283 aa, from Mycobacterium tuberculosis H37Rv, (100.0% FT identity in 283 aa overlap). nat (alternate gene name: FT nhoA), arylamine N-acetyltransferase (EC 2.3.1.5) (see FT citation below), highly similar to O86309|NAT_MYCSM FT ARYLAMINE N-ACETYLTRANSFERASE from Mycobacterium smegmatis FT (see citation below) (275 aa), FASTA scores: opt: 1114, FT E(): 3e-66, (60.95% identity in 274 aa overlap). Also FT highly similar to others e.g. Q98D42|BAB51429|MLR4870 from FT Rhizobium loti (Mesorhizobium loti) (278 aa), FASTA scores: FT opt: 697, E(): 1.1e-38, (44.1% identity in 272 aa overlap); FT P77567|NHOA_ECOLI|B1463 from Escherichia coli strain K12 FT (281 aa), FASTA scores: opt: 537, E(): 4.4e-28, (38.85% FT identity in 273 aa overlap); Q00267|NHOA_SALTY from FT Salmonella typhimurium (281 aa), FASTA scores: opt: 507, FT E(): 4.3e-26, (34.8% identity in 273 aa overlap); etc. FT BELONGS TO THE ARYLAMINE N-ACETYLTRANSFERASE FAMILY. Note FT that previously known as nhoA (332 aa) and that nucleotide FT 4007874 has been changed since first submission (G FT deleted)." FT /db_xref="GOA:P0A5L9" FT /db_xref="HSSP:1GX3" FT /db_xref="InterPro:IPR001447" FT /db_xref="UniProtKB/Swiss-Prot:P0A5L9" FT /protein_id="CAD95782.1" FT /translation="MALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPLL FT GVPVDDLSPQALADKLVLRRRGGYCFEHNGLMGYVLAELGYRVRRFAARVVWKLAPDAP FT LPPQTHTLLGVTFPGSGGCYLVDVGFGGQTPTSPLRLETGAVQPTTHEPYRLEDRVDGF FT VLQAMVRDTWQTLYEFTTQTRPQIDLKVASWYASTHPASKFVTGLTAAVITDDARWNLS FT GRDLAVHRAGGTEKIRLADAAAVVDTLSERFGINVADIGERGALETRIDELLARQPGAD FT AP" FT CDS complement(200382..200648) FT /transl_table=11 FT /gene="Mb3597c" FT /locus_tag="Mb3597c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3597c, -, len: 88 aa. Equivalent to Rv3566A, len: FT 88 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 88 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TW68" FT /protein_id="CAD95783.1" FT /translation="MSGADPPTRRAFGQMARAATGWVSVSGQFAVAADTCRCEGTLFAV FT DPETHVANHNRCDIVGRLRDERPNTLRSVRRGDEVRMATWHWI" FT CDS complement(200934..201497) FT /transl_table=11 FT /gene="Mb3598c" FT /locus_tag="Mb3598c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3598c, -, len: 187 aa. Equivalent to Rv3567c, len: FT 187 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 187 aa overlap). Possible oxidoreductase FT (EC 1.-.-.-), similar to various oxidoreductases and FT hypothetical proteins e.g. O69360 ORF61 PROTEIN from FT Rhodococcus erythropolis (194 aa) FASTA scores: opt: 974, FT E(): 3e-59, (77.05% identity in 183 aa overlap); FT Q9JN75|MMYF PUTATIVE OXIDOREDUCTASE from Streptomyces FT coelicolor (174 aa), FASTA scores: opt: 451, E(): 1e-23, FT (43.65% identity in 158 aa overlap); P54990|NTAB_CHEHE|NMOB FT NITRILOTRIACETATE MONOOXYGENASE COMPONENT B (EC 1.14.13.-) FT from Chelatobacter heintzii (322 aa), FASTA scores: opt: FT 409, E(): 1.3e-20, (38.3% identity in 167 aa FT overlap)Chelatobacter heintzii; AAK62356 PUTATIVE NADH:FMN FT OXIDOREDUCTASE from Burkholderia sp. DBT1 (177 aa), FASTA FT scores: opt: 360, E(): 1.6e-17, (36.15% identity in 155 aa FT overlap)." FT /db_xref="GOA:Q7TW67" FT /db_xref="InterPro:IPR012349" FT /db_xref="UniProtKB/TrEMBL:Q7TW67" FT /protein_id="CAD95784.1" FT /translation="MSAQIDPRTFRSVLGQFCTGITVITTVHDDVPVGFACQSFAALSL FT EPPLVLFCPTKVSRSWQAIEASGRFCVNVLTEKQKDVSARFGSKEPDKFAGIDWRPSEL FT GSPIIEGSLAYIDCTVASVHDGGDHFVVFGAVESLSEVPAVKPRPLLFYRGDYTGIEPE FT KTTPAHWRDDLEAFLTTTTQDTWL" FT CDS complement(201512..202414) FT /transl_table=11 FT /gene="bphC" FT /locus_tag="Mb3599c" FT /product="PUTATIVE BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE BPHC FT (23OHBP OXYGENASE) (2,3-DIHYDROXYBIPHENYL DIOXYGENASE) FT (2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE) (DHBD)" FT /EC_number="1.13.11.39" FT /note="Mb3599c, bphC, len: 300 aa. Equivalent to Rv3568c, FT len: 300 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 300 aa overlap). Probable bphC, FT 2,3-dihydroxybiphenyl 1,2-dioxygenase (EC 1.13.11.39), FT highly similar to other e.g. Q9KWQ5|BPHC5 from Rhodococcus FT sp. RHA1 (300 aa), FASTA scores: opt: 1715, E(): 3.8e-103, FT (82.15% identity in 297 aa overlap); O50479|EDOB from FT Rhodococcus rhodochrous (300 aa) FASTA scores: opt: 1714, FT E(): 4.4e-103, (82.5% identity in 297 aa overlap); FT O69359|BPHC6 from Rhodococcus erythropolis (300 aa), FASTA FT scores: opt: 1647, E(): 9.1e-99, (78.25% identity in 299 aa FT overlap); Q9RBT2|BPHC1 from Pseudomonas sp. SY5 (301 aa) FT Pseudomonas sp. SY5 (298 aa) FASTA scores: opt: 767, E(): FT 3.9e-42, (42.8% identity in 299 aa overlap); FT P47228|BPHC_BURCE from Burkholderia cepacia (Pseudomonas FT cepacia) (297 aa), FASTA scores: opt: 670, E(): 6.8e-36, FT (40.55% identity in 296 aa overlap); etc. Contains PS00082 FT Extradiol ring-cleavage dioxygenases signature. BELONGS TO FT THE EXTRADIOL RING-CLEAVAGE DIOXYGENASE FAMILY." FT /db_xref="GOA:Q7TW66" FT /db_xref="HSSP:1DHY" FT /db_xref="InterPro:IPR000486" FT /db_xref="UniProtKB/TrEMBL:Q7TW66" FT /protein_id="CAD95785.1" FT /translation="MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMD FT DFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEATAAELADRRVDEM FT IRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVVLSTRDDAEALHFYRDV FT LGFRLRDSMRLPPRMVGRPADGPPAWLRFFGCNPRHHSLAFLPMPTSSGIVHLMVEVEQ FT ADDVGLCLDRALRRKVPMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIA FT RESTAVSLWGHDFTVGARG" FT CDS complement(202411..203286) FT /transl_table=11 FT /gene="bphD" FT /locus_tag="Mb3600c" FT /product="2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE FT HYDROLASE BPHD" FT /EC_number="3.7.1.-" FT /note="Mb3600c, bphD, len: 291 aa. Equivalent to Rv3569c, FT len: 291 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 291 aa overlap). Probable bphD, FT 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (EC FT 3.7.1.-), highly similar to others e.g. Q9KWQ6|BPHD2 from FT Rhodococcus sp. RHA1 (292 aa), FASTA scores: opt: 1468, FT E(): 1.3e-85, (75.5% identity in 294 aa overlap); Q52036 FT from Pseudomonas putida (286 aa), FASTA scores: opt: 785, FT E(): 1.9e-42, (45.1% identity in 295 aa overlap); FT Q52011|BPHD from Pseudomonas pseudoalcaligenes (286 aa), FT FASTA scores: opt: 774, E(): 9.3e-42, (44.05% identity in FT 295 aa overlap); P47229|BPHD_BURCE from Burkholderia FT cepacia (Pseudomonas cepacia) (286 aa) FASTA scores: opt: FT 772, E(): 1.2e-41, (44.5% identity in 295 aa overlap); etc. FT Contains PS00017 ATP/GTP-binding site motif A. SIMILAR TO FT ALPHA/BETA HYDROLASE FOLD." FT /db_xref="GOA:Q7TW65" FT /db_xref="HSSP:1IUP" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7TW65" FT /protein_id="CAD95786.1" FT /translation="MTATEELTFESTSRFAEVDVDGPLKLHYHEAGVGNDQTVVLLHGG FT GPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQLG FT LGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSV FT APTRENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAGADFEAGMM FT WREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNK FT LTIEFLGGGR" FT CDS complement(203301..204485) FT /transl_table=11 FT /gene="Mb3601c" FT /locus_tag="Mb3601c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3601c, -, len: 394 aa. Equivalent to Rv3570c, len: FT 394 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 394 aa overlap). Possible oxidoreductase FT (EC 1.-.-.-), most similar to hydroxylases and oxygenases FT (and also some similarity to acyl-coa dehydrogenases) e.g. FT O69349 HYDROXYLASE from Rhodococcus erythropolis (393 aa), FT FASTA scores: opt: 958, E(): 1.1e-53, (39.95% identity in FT 383 aa overlap); P26698|PIGM_RHOSO PIGMENT PROTEIN from FT Rhodococcus sp. strain ATCC 21145 (387 aa), FASTA scores: FT opt: 665, E(): 5.4e-35, (32.2% identity in 382 aa overlap); FT Q9ZGA9|LANZ5 OXYGENASE HOMOLOG from Streptomyces cyanogenus FT (397 aa) FASTA scores: opt: 588, E(): 4.5e-30, (30.55% FT identity in 386 aa overlap); Q9F0J3|NCNH HYDROXYLASE from FT Streptomyces arenae (405 aa), FASTA scores: opt: 580, E(): FT 1.5e-29, (31.25% identity in 336 aa overlap); O69789|BPFA FT INDOLE DIOXYGENASE from Rhodococcus opacus (399 aa), FASTA FT scores: opt: 558, E(): 3.7e-28, (31.8% identity in 387 aa FT overlap); etc." FT /db_xref="GOA:Q7TW64" FT /db_xref="InterPro:IPR013107" FT /db_xref="UniProtKB/TrEMBL:Q7TW64" FT /protein_id="CAD95787.1" FT /translation="MTSIQQRDAQSVLAAIDDLLPEIRDRAQATEDLRRLPDETVKALD FT DVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQRAQ FT EEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRP FT VDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLA FT TNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKV FT RIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIASIDRL FT FEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPGDTMV" FT CDS 204632..205708 FT /transl_table=11 FT /gene="hmp" FT /locus_tag="Mb3602" FT /product="POSSIBLE HEMOGLOBINE-RELATED PROTEIN HMP" FT /EC_number="1.-.-.-" FT /note="Mb3602, hmp, len: 358 aa. Equivalent to Rv3571, len: FT 358 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 358 aa overlap). Possible hmp, FT oxidoreductase, hemoglobine-related protein (see citation FT below) (EC 1.-.-.-), similar to several e.g. Q44253|ATDA5 FT ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter FT sp (336 aa) FASTA scores: opt: 748, E(): 1.5e-38, (34.95% FT identity in 346 aa overlap); P95533|TDNB ELECTRON TRANSFER FT PROTEIN from Pseudomonas putida (337 aa), FASTA scores: FT opt: 723, E(): 5.2e-37, (36.35% identity in 341 aa FT overlap); AAK65059|SMA0752 POSSIBLE DIOXYGENASE REDUCTASE FT SUBUNIT from Rhizobium meliloti (Sinorhizobium meliloti) FT (353 aa) FASTA scores: opt: 495, E(): 4.9e-23, (31.9% FT identity in 345 aa overlap); P76081|PAAE_ECOLI|B1392 FT PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE FT (356 aa), FASTA scores: opt: 364, E(): 5.1e-15, (34.45% FT identity in 357 aa overlap); Q9L131|HMPA FLAVOHEMOPROTEIN FT from Streptomyces coelicolor (398 aa), FASTA scores: opt: FT 352, E(): 3e-14, (32.8% identity in 247 aa overlap); etc. FT Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding FT region signature. Note that it has been shown hmp FT transcription increased at early stationary phase and is FT lower at late stationary phase and during exponential FT growth." FT /db_xref="GOA:Q7TW63</ |