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EBI DbfetchID BX248345; SV 1; linear; genomic DNA; STD; PRO; 308050 BP. XX AC BX248345; XX DT 10-JUN-2003 (Rel. 76, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 12/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-308050 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF00634; SAM-IV. XX FH Key Location/Qualifiers FH FT source 1..308050 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS 278..1147 FT /transl_table=11 FT /gene="Mb3147" FT /locus_tag="Mb3147" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb3147, -, len: 289 aa. Equivalent to Rv3124, len: FT 289 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 289 aa overlap). Probable FT transcriptional regulatory protein, similar to many FT Streptomyces and Mycobacterium tuberculosis regulatory FT proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15 FT from Mycobacterium tuberculosis strain H37Rv (388 aa), FT FASTA scores: opt: 963, E(): 2e-56, (55.15% identity in 252 FT aa overlap); O53145 from Mycobacterium tuberculosis (381 FT aa); P71484|EMBR from Mycobacterium avium (384 aa), FASTA FT scores: opt: 859, E(): 1.5e-49, (52.2% identity in 249 aa FT overlap); Q9XCC3|TYLT from Streptomyces fradiae (404 aa), FT FASTA scores: opt: 462, E(): 3.1e-23, (35.05% identity in FT 254 aa overlap); Q9XCC4|TYLS from Streptomyces fradiae (277 FT aa), FASTA scores: opt: 456, E(): 5.6e-23, (33.45% identity FT in 269 aa overlap); etc. Start chosen by similarity, FT alternative possible (see AAK47548 from Mycobacterium FT tuberculosis strain CDC1551, longer N-terminus (311 aa))." FT /db_xref="GOA:Q7TX77" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7TX77" FT /protein_id="CAD95239.1" FT /translation="MQFNVLGPLELNLRGTKLPLGTPKQRAVLAMLLLSRNQVVAADAL FT VQAIWEKSPPARARRTVHTYICNLRRTLSDAGVDSRNILVSEPPGYRLLIGDRQQCDLD FT RFVAAKESGLRASAKGYFSEAIRYLDSALQNWRGPVLGDLRSFMFVQMFSRALTEDELL FT VHTKLAEAAIACGRADVVIPKLERLVAMHPYRESLWKQLMLGYYVNEYQSAAIDAYHRL FT KSTLAEELGVEPAPTIRALYHKILRQLPMDDLVGRVTRGRVDLRGGNGAKVEELTESDK FT DLLPIGLA" FT CDS complement(1248..2423) FT /transl_table=11 FT /gene="PPE49" FT /locus_tag="Mb3148c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3148c, PPE49, len: 391 aa. Equivalent to Rv3125c, FT len: 391 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 391 aa overlap). Member of the M. FT tuberculosis PPE family, similar to other e.g. FT P95247|Rv2352c|MTCY98.21c (391 aa), FASTA scores: opt: FT 1576, E(): 3.8e-72, (62.55% identity in 398 aa overlap), FT MTCY98.0029c, MTCY03A2.22c, MTCY10G2.10, MTCY02B10.25c, FT MTCI364.08, M TCY21C12.09c, MTCY48.17." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TX76" FT /protein_id="CAD95240.1" FT /translation="MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAVDLWASAS FT SFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQARAAATAFEAALA FT ATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDYLEMWAQDVAAMVGYHAGAKSV FT AATLAPFSLPPVSLAGLAAQVGTQVAGMATTASAAVTPVVEGAMASVPTVMSGMQSLVS FT QLPLQHASMLFLPVRILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAAIPAFK FT PLGGRELGAGMSAGLGQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPVALTQAA FT GAAGGGMPMMLMPMSISGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG" FT CDS complement(2580..2894) FT /transl_table=11 FT /gene="Mb3149c" FT /locus_tag="Mb3149c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3149c, -, len: 104 aa. Equivalent to Rv3126c, len: FT 104 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 104 aa overlap). Hypothetical unknown FT protein. Shortened version of MTCY164.36c, avoiding FT overlap." FT /db_xref="UniProtKB/TrEMBL:Q7TX75" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95241.1" FT /translation="MVIRFDQIGSLVLSMKSLASLSFQRCLRENSSLVAALDRLDAAVD FT ELSALSFDALTTPERDRARRDRDHHPWSRSRSQLSPRMAHGAVHQCQWPKAVWAVIDNP FT " FT CDS 2919..3953 FT /transl_table=11 FT /gene="Mb3150" FT /locus_tag="Mb3150" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3150, -, len: 344 aa. Equivalent to Rv3127, len: FT 344 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 344 aa overlap). Hypothetical protein, FT highly similar to Mycobacterium tuberculosis protein FT O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 1212, FT E(): 6e-69, (56.7% identity in 321 aa overlap), and also FT similar to P95195|MTCY03A2.27c (332 aa), FASTA scores: opt: FT 521, E(): 1.6e-25; (35.0% identity in 326 aa overlap). Some FT similarity to C-terminal half of hypothetical Mycobacterium FT tuberculosis proteins." FT /db_xref="UniProtKB/TrEMBL:Q7TX74" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95242.1" FT /translation="MLKNAVLLACRAPSVHNSQPWRWVAESGSEHTTVHLFVNRHRTVP FT ATDHSGRQAIISCGAVLDHLRIAMTAAHWQANITRFPQPNQPDQLATVECSPIDHVTAG FT QRNRAQAILQRRTDRLPFDSPMYWHLFEPALRDAVDKDVAMLDVVSDDQRTRLVVASQL FT SEVLRRDDPYYHAELEWWTSPFVLAHGVPPDTLASDAERLRVDLGRDFPVRSYQNRRAE FT LADDRSKVLVLSTPSDTRADALRCGEVLSTILLECTMAGMATCTLTHLIESSDSRDIVR FT GLTRQRGEPQALIRVGIAPPLAAVPAPTPRRPLDSVLQIRQTPEKGRNASDRNARETGW FT FSPP" FT CDS complement(3940..4290) FT /transl_table=11 FT /gene="Mb3151c" FT /locus_tag="Mb3151c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3151c, -, len: 116 aa. Equivalent to 3' end of FT Rv3128c, len: 337 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 116 aa overlap). Conserved FT hypothetical protein, similar to other conserved FT hypothetical proteins. This ORF corresponds to a fusion of FT MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon FT but is similar throughout its length to FT Rv2807|MTCY16B7.36c|Z81331 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (384 aa), FASTA scores: FT opt: 954, E(): 0, (47.2% identity in 339 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv3128c exists as a single gene FT with an in-frame amber stop codon. In Mycobacterium bovis, FT Rv3128c is split into 2, Mb3151c and Mb3152c." FT /db_xref="UniProtKB/TrEMBL:Q7TX73" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95243.1" FT /translation="MLNRMWKLVNDRLNYLTPTIKPIGYASSADGRRRRLYDAPQTPLD FT RPLAARVLSAAQQADLITYRDSLNPAQIGRKIADLQNRLLILAKEKTEQLYLANIPTAL FT PDIHKGILIKAG" FT CDS complement(4372..4953) FT /transl_table=11 FT /gene="Mb3152c" FT /locus_tag="Mb3152c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3152c, -, len: 193 aa. Equivalent to 5' end of FT Rv3128c, len: 337 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 193 aa overlap). FT Conserved hypothetical protein, similar to other conserved FT hypothetical proteins. This ORF corresponds to a fusion of FT MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon FT but is similar throughout its length to FT Rv2807|MTCY16B7.36c|Z81331 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (384 aa), FASTA scores: FT opt: 954, E(): 0, (47.2% identity in 339 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv3128c exists as a single gene FT with an in-frame amber stop codon. In Mycobacterium bovis, FT Rv3128c is split into 2, Mb3151c and Mb3152c." FT /db_xref="GOA:Q7TX72" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/TrEMBL:Q7TX72" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95244.1" FT /translation="MWSASGGQCGKYLAASMVLQLDGLERHGVLEFGRDRYGPEVREEL FT LAMSAASIDRYLKTAKAKDQISGVSTTKPSPLLRNSIKVRRAGDEVEAEPGFFEGDTVA FT HCGPTLKGEFAHTLNLTDVHIGWVFTRTVRNNARTHILAGLKASVTEIPHGITGLDFDN FT GTGFLNKPVISWAGDNGIYFTRFRPYKKNH" FT CDS 5432..5764 FT /transl_table=11 FT /gene="Mb3153" FT /locus_tag="Mb3153" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3153, -, len: 110 aa. Equivalent to Rv3129, len: FT 110 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 110 aa overlap). Conserved hypothetical FT protein, with some similarity to various hypothetical FT proteins from Streptomyces coelicolor e.g. Q9RI34|SCJ12.26 FT HYPOTHETICAL 14.5 KDA PROTEIN (137 aa), FASTA scores: opt: FT 141, E(): 0.0016, (39.3% identity in 84 aa overlap); FT Q9RI49|SCJ12.09c HYPOTHETICAL 15.8 KDA PROTEIN (146 aa), FT FASTA scores: opt: 141, E(): 0.0017, (38.05% identity in 92 FT aa overlap); Q9RJ05|SCJ1.09C POSSIBLE DNA-BINDING PROTEIN FT (233 aa), FASTA scores: opt: 140, E(): 0.0029, (34.85% FT identity in 89 aa overlap); Q9XA48|SCGD3.31c PUTATIVE FT BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA FT SUBUNIT (334 aa); etc." FT /db_xref="UniProtKB/TrEMBL:Q7TX71" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95245.1" FT /translation="MVQGRTVLFRTAEGAKLFSAVAKCAVAFEADDHNVAEGWSVIVKV FT RAQVLTTDAGVREAERAQLLPWTATLKRHCVRVIPWEITGRHFRFGPEPDRSQTFACEA FT SSHNQR" FT CDS complement(5747..7138) FT /transl_table=11 FT /gene="Mb3154c" FT /locus_tag="Mb3154c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3154c, -, len: 463 aa. Equivalent to Rv3130c, len: FT 463 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 463 aa overlap). Conserved hypothetical FT protein, similar to several other hypothetical FT Mycobacterium tuberculosis strain H37Rv proteins e.g. FT O06795|YH60_MYCTU|Rv1760|MTCY28.26 HYPOTHETICAL 54.1 KDA FT PROTEIN (502 aa), FASTA scores: opt: 586, E(): 9.8e-29, FT (28.95% identity in 463 aa overlap)." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/Swiss-Prot:P0A651" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95246.1" FT /translation="MNHLTTLDAGFLKAEDVDRHVSLAIGALAVIEGPAPDQEAFLSSL FT AQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWRIALPRPGNEDQLFELIADL FT MARRLDRGRPLWEVWVIEGLADSKWAILTKLHHCMADGIAATHLLAGLSDESMSDSFAS FT NIHTTMQSQSASVRRGGFRVNPSEALTASTAVMAGIVRAAKGASEIAAGVLSPAASSLN FT GPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNVLIQRGERPRFDSLR FT TLVPVSTRSNSALSKTDNRVSLMLPNLPVDQENPLQRLRIVHSRLTRAKAGGQRQFGNT FT LMAIANRLPFPMTAWAVGLLMRLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIA FT MQLRTSVAMLSYADDLYFGILADYDVVADAGQLARGIEDAVARLVAISKRRKVTRRRGA FT LSLVV" FT CDS 7323..8321 FT /transl_table=11 FT /gene="Mb3155" FT /locus_tag="Mb3155" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3155, -, len: 332 aa. Equivalent to Rv3131, len: FT 332 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 332 aa overlap). Hypothetical protein, FT similar to other hypothetical bacterial proteins e.g. FT O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 568, FT E(): 2.5e-27, (36.7% identity in 321 aa overlap); FT O05800|Rv3127|MTCY164.37 (344 aa), FASTA scores: opt: 521, FT E(): 1.9e-24, (34.95% identity in 326 aa overlap); FT Q9RI33|SCJ12.27c from Streptomyces coelicolor (335 aa), FT FASTA scores: opt: 441, E(): 1.3e-19, (35.75% identity in FT 319 aa overlap); Q9RI44|SCJ12.14 from Streptomyces FT coelicolor (309 aa), FASTA scores: opt: 328, E(): 9.3e-13, FT (27.9% identity in 308 aa overlap); Q9CBP5|ML1751 from FT Mycobacterium leprae (721 aa), FASTA scores: opt: 137, E(): FT 0.78, (26.15% identity in 298 aa overlap); etc. Equivalent FT to AAK47555 from Mycobacterium tuberculosis strain CDC1551 FT but shorter 12 aa." FT /db_xref="GOA:Q7TX70" FT /db_xref="InterPro:IPR000415" FT /db_xref="UniProtKB/TrEMBL:Q7TX70" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95247.1" FT /translation="MNTHFPDAETVRTVLTLAVRAPSIHNTQPWRWRVCPTSLELFSRP FT DMQLRSTDPDGRELILSCGVALHHCVVALASLGWQAKVNRFPDPKDRCHLATIGVQPLV FT PDQADVALAAAIPRRRTDRRAYSCWPVPGGDIALMAARAARGGVMLRQVSALDRMKAIV FT AQAVLDHVTDEEYLRELTIWSGRYGSVAGVPARNEPPSDPSAPIPGRLFAGPGLSQPSD FT VLPADDGAAILALGTETDDRLARLRAGEAASIVLLTATAMGLACCPITEPLEIAKTRDA FT VRAEVFGAGGYPQMLLRVGWAPINADPLPPTPRRELSQVVEWPEELLRQRC" FT CDS complement(8301..10037) FT /transl_table=11 FT /gene="devS" FT /locus_tag="Mb3156c" FT /product="TWO COMPONENT SENSOR HISTIDINE KINASE DEVS" FT /EC_number="2.7.3.-" FT /note="Mb3156c, devS, len: 578 aa. Equivalent to Rv3132c, FT len: 578 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 578 aa overlap). devS, membrane-bound FT two component sensor histidine kinase (EC 2.7.3.-) (see FT citations below; dev for Differentially Expressed in FT Virulent strain), similar to others two component sensors FT e.g. Q9RI43|SCJ12.15c PUTATIVE TWO-COMPONENT SENSOR from FT Streptomyces coelicolor (585 aa), FASTA scores: opt: 1305, FT E(): 2.5e-69, (41.35% identity in 573 aa overlap); FT Q9ZBY4|SCD78.15 PUTATIVE TWO COMPONENT SENSOR from FT Streptomyces coelicolor (560 aa), FASTA scores: opt: 1194, FT E(): 8.1e-63, (41.05% identity in 558 aa overlap); FT O85371|CPRS TWO COMPONENT REGULATOR from Rhodococcus sp FT (563 aa), FASTA scores: opt: 803, E(): 8.3e-40, (38.4% FT identity in 552 aa overlap); Q9L094|SCC24.23 PUTATIVE FT TWO-COMPONENT SENSOR HISTIDINE KINASE from Streptomyces FT coelicolor (similarity only in C-terminus for this one); FT etc. Also highly similar to mycobacterium FT O53473|Rv2027c|MTV018.14c PUTATIVE MEMBRANE PROTEIN (573 FT aa), FASTA scores: opt: 2333, E(): 7.6e-130, (61.45% FT identity in 576 aa overlap)." FT /db_xref="GOA:Q7TX69" FT /db_xref="InterPro:IPR003018" FT /db_xref="UniProtKB/TrEMBL:Q7TX69" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95248.1" FT /translation="MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGR FT DRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGID FT EETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVR FT DESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDI FT ATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVA FT STVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVV FT VLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVI FT QRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQ FT RIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRV FT KVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPL FT SQ" FT CDS complement(10034..10687) FT /transl_table=11 FT /gene="devR" FT /locus_tag="Mb3157c" FT /product="TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN FT DEVR (PROBABLY LUXR/UHPA-FAMILY)" FT /note="Mb3157c, devR, len: 217 aa. Equivalent to Rv3133c, FT len: 217 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 217 aa overlap). devR, two component FT transcriptional regulator (see first citation below; dev FT for Differentially Expressed in Virulent strain), highly FT similar to several e.g. O85372|CPRR TWO COMPONENT REGULATOR FT from Rhodococcus sp. (212 aa), FASTA scores: opt: 868, E(): FT 6.2e-46, (65.05% identity in 206 aa overlap); FT Q9RI42|SCJ12.16c PUTATIVE LUXR FAMILY TWO-COMPONENT FT RESPONSE REGULATOR from Streptomyces coelicolor (233 aa), FT FASTA scores: opt: 849, E(): 9.7e-45, (60.55% identity in FT 218 aa overlap); Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT FT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces FT coelicolor (218 aa), FASTA scores: opt: 835, E(): 6.5e-44, FT (61.55% identity in 208 aa overlap); and similar to others. FT Contains bacterial regulatory proteins, LuxR family FT signature (PS00622) near C-terminus as seen in bvgA, comA, FT dctR, degU, evgA, fimZ, fixJ, gacA, glpR, narL, narP, nodW, FT rcsB and uhpA. Helix-turn-helix motif at 166-187 (+3.15 FT SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL FT REGULATORS. THE N-TERMINAL REGION IS SIMILAR TO THAT OF FT OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION FT SYSTEMS." FT /db_xref="GOA:Q8GGH2" FT /db_xref="HSSP:1FSE" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:Q8GGH2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95249.1" FT /translation="MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPA FT ARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVK FT DIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSE FT GLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP" FT CDS complement(10715..11521) FT /transl_table=11 FT /gene="Mb3158c" FT /locus_tag="Mb3158c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3158c, -, len: 268 aa. Equivalent to Rv3134c, len: FT 268 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 268 aa overlap). Conserved Ala-, Val- FT rich protein (see citations below), related to other FT hypothetical Mycobacterium tuberculosis proteins e.g. FT O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 562, FT E(): 3.2e-28, (40.65% identity in 273 aa overlap); FT O06188|Rv2624c|MTCY01A10.08 (272 aa), FASTA scores: opt: FT 458, E(): 1.1e-21, (36.55% identity in 271 aa overlap); FT O53472|R2026c|MTV018.13c (294 aa), FASTA scores: opt: 232, FT E(): 1.9e-07, (30.45% identity in 276 aa overlap); etc. FT Shares some similarity with other hypothetical proteins FT from Streptomyces coelicolor e.g. Q9RIZ8|SCJ1.16c (294 aa), FT FASTA scores: opt: 207, E(): 6.9e-06, (28.9% identity in FT 263 aa overlap); Q9K4L5|SC5F8.09 PUTATIVE STRESS-INDUCIBLE FT PROTEIN (312 aa), FASTA scores: opt: 204, E(): 1.1e-05, FT (28.4% identity in 271 aa overlap); etc. Equivalent to FT AAK47558|MT3220 Universal stress protein family from FT Mycobacterium tuberculosis strain CDC1551 (268 aa). Rv3134c FT seems cotranscribed with devR-devS (see second citation FT below)." FT /db_xref="GOA:Q7TX68" FT /db_xref="InterPro:IPR006015" FT /db_xref="UniProtKB/TrEMBL:Q7TX68" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95250.1" FT /translation="MSDPRPARAVVVGIDGSRAATHAALWAVDEAVNRDIPLRLVYVID FT PSQLSAAGEGGGQSAARAALHDASRKVEATGQPVKIETEVLCGRPLTKLMQESRSAAML FT CVGSVGLDHVRGRRGSVAATLAGSALCPVAVIHPSPAEPATTSQVSAVVAEVDNGVVLR FT HAFEEARLRGVPLRAVAVHAAETPDDVEQGSRLAHVHLSRRLAHWTRLYPEVRVDRAIA FT GGSACRHLAANAKPGQLFVADSHSAHELCGAYQPGCAVLTVRSANL" FT CDS 12106..13251 FT /transl_table=11 FT /gene="PPE50" FT /locus_tag="Mb3159" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3159, PPE50, len: 381 aa. Similar to 5' end of FT Rv3135, len: 132 aa, from Mycobacterium tuberculosis strain FT H37Rv, (88.5% identity in 131 aa overlap). Member of the FT Mycobacterium tuberculosis Ala-, Gly-rich PPE family, FT similar to P95190|Rv3136|MTCY03A2.22c (380 aa), FASTA FT scores: opt: 494, E(): 6.7e-25, (57.25% identity in 131 aa FT overlap) (next ORF downstream), MTY21C12_9, MTCY3C7_24, FT MTCI125_27, MTV049_12, MTV049_9, MTV049_11 , MTCY274_24 FT etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT a large 1337 bp insertion leads to a longer product with a FT different COOH part compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 FT aa)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TX67" FT /protein_id="CAD95251.1" FT /translation="MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENY FT GSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTATQARAAAAAFEQAHAMT FT VPPALVTANRAELKALIASNLLGQNTAAIAAIEAQYAEMWAQDAAAMYGYATTSAAARQ FT LTPFSSPQQTTNPAGLAAQNAAVTQAATNSAGNTPTALSQLSSFLSQAVEAPTGWPNIL FT PDDFTILDGILAAYATVGVTQDIESICAGIIGAENNLGLLGAASENPAELAPGAFGIDA FT ALSSAEKGAAASMHDAVLASAGRAGSIGPMSVPPSWATPSSTPVSALSGAGLTTLDGTD FT VAEHGTPGLPGVPAGTDKRASGVIPRYGVRLTVMSRPPAAG" FT CDS 13903..15045 FT /transl_table=11 FT /gene="PPE51" FT /locus_tag="Mb3160" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3160, PPE51, len: 380 aa. Equivalent to Rv3136, FT len: 380 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 380 aa overlap). Member of the FT Mycobacterium tuberculosis Ala-, Gly-rich PPE family, FT similar to Q9AGF0|Ov2770c Rv2770c-LIKE PROTEIN from M. FT microti (397 aa), FASTA scores: opt: 917, E(): 9e-41, FT (46.15% identity in 388 aa overlap); FT O33312|Rv2770c|MTV002.35c, MTV002_36, MTCI125_26, FT MTCY10G2_10, MTCI364_8, MTV049_28, MTV049_29, etc. TBparse FT score is 0.923." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TX66" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95252.1" FT /translation="MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAELATTAEAY FT GSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTAIQARAAALAFEQAYAMT FT LPPPVVAANRIQLLALIATNFFGQNTAAIAATEAQYAEMWAQDAAAMYGYATASAAAAL FT LTPFSPPRQTTNPAGLTAQAAAVSQATDPLSLLIETVTQALQALTIPSFIPEDFTFLDA FT IFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEVTPGDFGIGELVSATSPGG FT GVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSALSPAGLTTLPGTD FT VAEHGMPGVPGVPVAAGRASGVLPRYGVRLTVMAHPPAAG" FT CDS 15502..16284 FT /transl_table=11 FT /gene="Mb3161" FT /locus_tag="Mb3161" FT /product="PROBABLE MONOPHOSPHATASE" FT /EC_number="3.1.3.-" FT /note="Mb3161, -, len: 260 aa. Equivalent to Rv3137, len: FT 260 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 260 aa overlap). Probable FT monophosphatase (EC 3.1.3.-), equivalent to FT O32889|MLCB1779_19|ML0662 PUTATIVE MONOPHOSPHATASE from FT Mycobacterium leprae (255 aa), FASTA scores: opt: 1403, FT E(): 1.2e-81, (81.8% identity in 253 aa overlap). Also FT similar to Q9K4B1|SC7E4.05c from Streptomyces coelicolor FT (266 aa), FASTA scores: opt: 969, E(): 3.5e-54, (57.9% FT identity in 259 aa overlap); Q53743|PUR3 MONO-PHOSPHATASE FT from Streptomyces lipmanii (Streptomyces alboniger) (273 FT aa), FASTA scores: opt: 862, E(): 2.1e-47, (55.25% identity FT in 257 aa overlap); BAB50023|MLL3039 MONO-PHOSPHATASE from FT Rhizobium loti (Mesorhizobium loti) (262 aa), FASTA scores: FT opt: 448, E(): 3.2e-21, (31.37% identity in 255 aa FT overlap); etc. Contains inositol monophosphatase family FT signature 1 (PS00629)." FT /db_xref="GOA:Q7TX65" FT /db_xref="HSSP:1KA1" FT /db_xref="InterPro:IPR017955" FT /db_xref="UniProtKB/TrEMBL:Q7TX65" FT /protein_id="CAD95253.1" FT /translation="MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADR FT AVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLIAL FT LEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSSLS FT GWARLGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVR FT EAGGRLTSLDGVAGPHGGSAVATNGLLHDEVLTRLNAG" FT CDS 16304..17392 FT /transl_table=11 FT /gene="pflA" FT /locus_tag="Mb3162" FT /product="PROBABLE PYRUVATE FORMATE LYASE ACTIVATING FT PROTEIN PFLA (FORMATE ACETYLTRANSFERASE ACTIVATING ENZYME) FT ([PYRUVATE FORMATE-LYASE] ACTIVATING ENZYME)" FT /EC_number="1.97.1.4" FT /note="Mb3162, pflA, len: 362 aa. Equivalent to Rv3138, FT len: 362 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.9% identity in 362 aa overlap). Probable pflA, pyruvate FT formate lyase activating protein (EC 1.97.1.4), similar to FT other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi (348 aa), FT FASTA scores: opt: 926, E(): 1.1e-52, (39.95% identity in FT 343 aa overlap); O27446|MTH1395 from Methanobacterium FT thermoautotrophicum (335 aa), FASTA scores: opt: 909, E(): FT 1.3e-51, (42.2% identity in 327 aa overlap); O28939|AF1330 FT from Archaeoglobus fulgidus (336 aa), FASTA scores: opt: FT 884, E(): 5.6e-50, (42.0% identity in 319 aa overlap); etc. FT Also similar to O50099|PH1391 HYPOTHETICAL 40.2 KDA PROTEIN FT from Pyrococcus horikoshii (348 aa), FASTA scores: opt: FT 934, E(): 3.3e-53, (40.5% identity in 343 aa overlap); and FT other hypothetical proteins. TBparse score is 0.881." FT /db_xref="GOA:Q7TX64" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/TrEMBL:Q7TX64" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95254.1" FT /translation="MSDPFTIATKHWHRLHDSRIQCDVCPRACKLHEGQRGLCFVRGRF FT DDQVKLTSYGRSSGFCVDPIEKKPLNHFLPGSATLSFGTAGCNLACKFCQNWDISKSRE FT IDVLANRAAPADIARTAHELGCRSVAFTYNDPTIFWEYAADVADACHDQGIKAVAVTAG FT YMCPEPRAEFYRRVDAANVDLKAFTEDFYRKVCVSHLRNVLDTLAYLRHQTNVWLEITT FT LLIPGRNDSDAEVAAECRWIRENLGVDVPVHFTASHPDYKMMDTPATLPATLTRAREIG FT IGEGLRFVYTGNVHDAVGGSTSCPGCRATVIVRDWYSIRHYALTEDGRCQACGYQMPGV FT YDGPAGHWGQRRLPLLTSLSRM" FT CDS 17472..18878 FT /transl_table=11 FT /gene="fadE24" FT /locus_tag="Mb3163" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE24" FT /EC_number="1.3.99.-" FT /note="Mb3163, fadE24, len: 468 aa. Equivalent to Rv3139, FT len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 468 aa overlap). Probable fadE24, FT acyl-CoA dehydrogenase (1.3.99.-), equivalent to FT O32890|MLCB1779.30|FADE24|ML0661 PUTATIVE ACYL-CoA FT DEHYDROGENASE from Mycobacterium leprae (465 aa), FASTA FT scores: opt: 2587, E(): 4e-153, (83.6% identity in 464 aa FT overlap). Similar to other e.g. Q9HUH0|PA4995 from FT Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 1139, FT E(): 2.8e-63, (45.3% identity in 426 aa overlap); FT Q9K6D0|MMGC|BH3799 from Bacillus halodurans (379 aa), FASTA FT scores: opt: 603, E(): 4.7e-30, (30.3% identity in 366 aa FT overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 FT aa), FASTA scores: opt: 601, E(): 6.3e-30, (32.25% identity FT in 363 aa overlap); etc. Contains acyl-CoA dehydrogenases FT signature 2 (PS00073) near C-terminus. BELONGS TO THE FT ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.881." FT /db_xref="GOA:Q7TX63" FT /db_xref="HSSP:1UDY" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TX63" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95255.1" FT /translation="MTNTTSAANAAKPSGARTDRRGRTTGVGLAPHKRTGIDVALALLT FT PIVGQEFLDKYRLRDPLNRSLRYGVKTMFATAGAATRQFQRVQGLRGGPTRLKSSGRDY FT FDLTPDDDQKLIIETVDEFAEEVLRPAAHDADDAATYPSDLTAKAAELGITAINIPEDF FT DGIAEHRSSVTNVLVAEALAYGDMGLALPILAPGGVASALTHWGSADQQATYLKEFAGE FT NVPQACVAITEPQPLFDPTRLKTTAVRTPSGYRLDGVKSLIPAAADAELFIVGAQLGGK FT PALFIVESAASGLTVKADPSMGIRGAALGQVELCGVSVPLNARLGEDEASDNDYSEALA FT LARLGWAALAVGTSHAVLDYVVPYVKQRQAFGEPIAHRQAVAFMCANIAIELDGLRLIT FT WRGASRAEQGLPFAREAALAKRLGSDKGMQIGLDGVQLLGGHGYTKEHPVERWYRDLRA FT IGVAEGVVVI" FT CDS 18899..20104 FT /transl_table=11 FT /gene="fadE23" FT /locus_tag="Mb3164" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE23" FT /note="Mb3164, fadE23, len: 401 aa. Equivalent to Rv3140, FT len: 401 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 401 aa overlap). Probable fadE23, FT acyl-CoA dehydrogenase (1.3.99.-) (see citation below), FT equivalent to O32891|MLCB1779.31|FADE23|ML0660 PUTATIVE FT ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (400 aa), FT FASTA scores: opt: 2307, E(): 3e-136, (89.5% identity in FT 401 aa overlap). Also similar to others e.g. Q9HUH1|PA4994 FT from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: FT 1558, E(): 1.2e-89, (61.0% identity in 400 aa overlap); FT O31251 from Acinetobacter sp. ADP1 (401 aa), FASTA scores: FT opt: 1509, E(): 1.3e-86, (58.2% identity in 402 aa FT overlap); Q9K6D1|ACDA OR BH3798 from Bacillus halodurans FT (380 aa), FASTA scores: opt: 612, E(): 8.4e-31, (38.2% FT identity in 293 aa overlap); Q9AHX9|FADFX from Pseudomonas FT putida (375 aa), FASTA scores: opt: 584, E(): 4.6e-29, FT (32.7% identity in 379 aa overlap); etc. COULD BELONG TO FT THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is FT 0.890." FT /db_xref="GOA:Q7TX62" FT /db_xref="HSSP:1UDY" FT /db_xref="InterPro:IPR006091" FT /db_xref="UniProtKB/TrEMBL:Q7TX62" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95256.1" FT /translation="MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELD FT TLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPY FT QGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKI FT FVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRF FT DNARIPKGNLLGNPEIEVGKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAG FT VEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGR FT MASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSE FT LK" FT CDS 20204..21175 FT /transl_table=11 FT /gene="fadB4" FT /locus_tag="Mb3165" FT /product="PROBABLE NADPH QUINONE OXIDOREDUCTASE FADB4 FT (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN)" FT /EC_number="1.6.5.5" FT /note="Mb3165, fadB4, len: 323 aa. Equivalent to Rv3141, FT len: 323 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 323 aa overlap). Probable fadB4, FT quinone oxidoreductase (EC 1.6.5.5), showing strong FT similarity to variety of quinone oxidoreductases and FT domains in polyketide and fatty acid synthases e.g. FT Q9HTV6|PA5234 PROBABLE OXIDOREDUCTASE from Pseudomonas FT aeruginosa (325 aa), FASTA scores: opt: 737, E(): 1.4e-35, FT (39.65% identity in 328 aa overlap); Q9RYQ7|DRA0251 FT PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus FT radiodurans (336 aa), FASTA scores: opt: 688, E(): 1e-32, FT (40.6% identity in 325 aa overlap); Q9RVG8|DR1061 PUTATIVE FT NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans FT (388 aa), FASTA scores: opt: 559, E(): 3.3e-25, (36.3% FT identity in 325 aa overlap); BAB49685|MLL2594 PROBABLE FT QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium FT loti) (326 aa), FASTA scores: opt: 519, E(): 5.9e-23, FT (34.25% identity in 330 aa overlap); Q9LXZ4|T5P19_110 FT QUINONE REDUCTASE-LIKE PROTEIN from Arabidopsis thaliana FT (348 aa), FASTA scores: opt: 517, E(): 8.1e-23, (33.55% FT identity in 322 aa overlap); etc. Also similar to FT Q9AA38|CC0770 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from FT Caulobacter crescentus (325 aa), FASTA scores: opt: 673, FT E(): 7.2e-32, (40.2% identity in 326 aa overlap); and FT Q9ABX4|CC0096 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from FT Caulobacter crescentus (332 aa), FASTA scores: opt: 623, FT E(): 5.7e-29, (40.7% identity in 334 aa overlap). Also FT resembles Mycobacterium tuberculosis proteins FT P96826|Rv0149|MTCI5_23, MTCY13D12.11, MTCY24G1.03, FT MTCY19H9.01. BELONGS TO THE ZINC-CONTAINING ALCOHOL FT DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY. FT TBparse score is 0.904. Thought to be differentially FT expressed within host cells (see first citation below)." FT /db_xref="GOA:Q7TX61" FT /db_xref="HSSP:1IYZ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TX61" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95257.1" FT /translation="MRAVRVTRLEGPDAVEVAEVEEPTSAGVVIEVHAAGVAFPDALLT FT RGRYQYRPEPPFVLGAEIAGVVRSAPDNSQVRSGDRVVGLTMLTGGMAEVAVLSPERVF FT KLPDNMTFEAGAGVLFNDLTVYFALAVRGRLQAGETVLVHGAAGGIGTSTLRLAPALGA FT SRTVAVVSTQEKAELATVAGATDVVLAEGFKDAVQELTNGRGVDIVVDPVGGDRFTDSL FT RSLAAGGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWSLTHPDALAQQWSQLER FT LLRSGKLPPPEPVVYPLDQAAAAIASLENRTAKGKVVLRVRD" FT CDS complement(21227..21655) FT /transl_table=11 FT /gene="Mb3166c" FT /locus_tag="Mb3166c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3166c, -, len: 142 aa. Equivalent to Rv3142c, len: FT 142 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 142 aa overlap). Hypothetical unknown FT protein. Equivalent to AAK47569 from Mycobacterium FT tuberculosis strain CDC1551 but shorter 33 aa." FT /db_xref="UniProtKB/TrEMBL:Q7TX60" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95258.1" FT /translation="MTEQEMTEQWLEGCAVQRIMFRDGLVLNFDDYNELVISVPLQLTL FT PAIETSPAEVVAIDPNDPADHERPLFDFAGATCTAFVWYDTGDLHLEFSDGHQIDVHPD FT DRVTAWELYGKYHGYAACLAPGKLRVVRQDVADANGDQ" FT CDS 21763..22164 FT /transl_table=11 FT /gene="Mb3167" FT /locus_tag="Mb3167" FT /product="PROBABLE RESPONSE REGULATOR" FT /note="Mb3167, -, len: 133 aa. Equivalent to Rv3143, len: FT 133 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 133 aa overlap). Probable response FT regulator, similar to other sensory transduction regulatory FT proteins e.g. Q9X810|SC6G10.25 from Streptomyces coelicolor FT (133 aa), FASTA scores: opt: 474, E(): 2.8e-24, (54.15% FT identity in 120 aa overlap); Q9KZ82|SCE25.04c from FT Streptomyces coelicolor (225 aa), FASTA scores: opt: 144, FT E(): 0.016, (32.3% identity in 127 aa overlap); FT Q9RZT4|DRB0029 from Deinococcus radiodurans (416 aa), FASTA FT scores: opt: 145, E(): 0.024, (30.65% identity in 124 aa FT overlap). SIMILAR TO OTHER REGULATORY COMPONENTS OF SENSORY FT TRANSDUCTION SYSTEMS." FT /db_xref="GOA:Q7TX59" FT /db_xref="InterPro:IPR001789" FT /db_xref="UniProtKB/TrEMBL:Q7TX59" FT /protein_id="CAD95259.1" FT /translation="MPDSSTALRILVYSDNVQTRERVMRALGKRLHPDLPDLTYVEVAT FT GPMVIRQMDRGGIDLAILDGEATPTGGMGIAKQLKDELASCPPILVLTGRPDDTWLASW FT SRAEAAVPHPVDPIVLGRTVLSLLRAPAH" FT CDS complement(22197..23426) FT /transl_table=11 FT /gene="PPE52" FT /locus_tag="Mb3168c" FT /product="PPE-FAMILY PROTEIN" FT /note="Mb3168c, PPE52, len: 409 aa. Equivalent to Rv3144c, FT len: 409 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 409 aa overlap). Member of the M. FT tuberculosis PPE family, Gly-, Ala-rich, similar to others FT e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: FT opt: 1007, E(): 5.2e-35, (56.2% identity in 306 aa FT overlap); and MTV014_3, MTCY6G11_5, MTCY98.0034c, FT MTCY31.06c, MTCY48.17, MTCY98.0029c, MTCY03C7.17c, etc." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TX58" FT /protein_id="CAD95260.1" FT /translation="MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSF FT ASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQAAT FT VLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASAIAA FT QVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGTGGATASGGGVG FT YVGGGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPLA FT LAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVA FT AKAAPLSTTRVGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVR FT QDPKIQMRGG" FT CDS 23791..24177 FT /transl_table=11 FT /gene="nuoA" FT /locus_tag="Mb3169" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN A) NUOA FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN A)" FT /EC_number="1.6.5.3" FT /note="Mb3169, nuoA, len: 128 aa. Equivalent to Rv3145, FT len: 128 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 128 aa overlap). Probable nuoA, FT integral membrane NADH dehydrogenase, chain A (EC 1.6.5.3), FT similar to others e.g. Q9XAQ4|NUOA from Streptomyces FT coelicolor (119 aa), FASTA scores: opt: 405, E(): 5.4e-20, FT (68.75% identity in 128 aa overlap); Q9RU86|DR1506 from FT Deinococcus radiodurans (160 aa), FASTA scores: opt: 327, FT E(): 9e-15, (40.3% identity in 124 aa overlap); FT BAB47039|NDHC from Triticum aestivum (Wheat), FASTA scores: FT opt: 273, E(): 2.6e-11, (38.1% identity in 126 aa overlap); FT etc. Also similar to a NADH-PLASTOQUINONE OXIDOREDUCTASES FT e.g. P26303|NU3C_WHEAT|NDHC from Triticum aestivum (Wheat) FT (120 aa), FASTA scores: opt: 273, E(): 2.6e-1, (38.1% FT identity in 126 aa overlap). BELONGS TO THE COMPLEX I FT SUBUNIT 3 FAMILY. TBparse score is 0.895." FT /db_xref="GOA:P65564" FT /db_xref="InterPro:IPR000440" FT /db_xref="UniProtKB/Swiss-Prot:P65564" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95261.1" FT /translation="MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGI FT EPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFALVE FT MAIFMLTVFVAYAYVWRRGGLTWD" FT CDS 24186..24740 FT /transl_table=11 FT /gene="nuoB" FT /locus_tag="Mb3170" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN B) NUOB FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN B)" FT /EC_number="1.6.5.3" FT /note="Mb3170, nuoB, len: 184 aa. Equivalent to Rv3146, FT len: 184 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 184 aa overlap). Probable nuoB, NADH FT dehydrogenase, chain B (EC 1.6.5.3), similar to others e.g. FT Q9XAQ5|NUOB from Streptomyces coelicolor (184 aa), FASTA FT scores: opt: 989, E(): 1.4e-56, (78.25% identity in 184 aa FT overlap); Q56218|NQO6_THETH|NQO6 from Thermus aquaticus FT (subsp. thermophilus) (181 aa), FASTA scores: opt: 720, FT E(): 2.6e-39, (64.45% identity in 152 aa overlap); FT Q9RU87|DR1505 from Deinococcus radiodurans (181 aa), FASTA FT scores: opt: 719, E(): 3e-39, (62.6% identity in 155 aa FT overlap); etc. BELONGS TO THE COMPLEX I 20 KDA SUBUNIT FT FAMILY. MAY CONTAIN AN IRON-SULFUR 4FE-4S CLUSTER. TBparse FT score is 0.912." FT /db_xref="GOA:P65576" FT /db_xref="InterPro:IPR014406" FT /db_xref="UniProtKB/Swiss-Prot:P65576" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95262.1" FT /translation="MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMAT FT AGPRFDIARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCA FT SSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQQMPLGINRERAI FT AEAEEAALLARPTIEMRGLLR" FT CDS 24737..25447 FT /transl_table=11 FT /gene="nuoC" FT /locus_tag="Mb3171" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN C) NUOC FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN C)" FT /EC_number="1.6.5.3" FT /note="Mb3171, nuoC, len: 236 aa. Equivalent to Rv3147, FT len: 236 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 236 aa overlap). Probable nuoC, NADH FT dehydrogenase, chain C (EC 1.6.5.3), similar to others e.g. FT Q9XAQ6|NUOC from Streptomyces coelicolor (251 aa), FASTA FT scores: opt: 1113, E(): 2.6e-64, (67.35% identity in 236 aa FT overlap); Q9A6X2|CC1954 from Caulobacter crescentus (197 FT aa), FASTA scores: opt: 351, E(): 1.6e-15, (41.65% identity FT in 132 aa overlap); BAB48757|MLL1369 from Rhizobium loti FT (Mesorhizobium loti) (201 aa), FASTA scores: opt: 347, E(): FT 3e-15, (42.4% identity in 132 aa overlap); etc. Also FT similar to Q9UUU0|NUGM NUGM PROTEIN PRECURSOR (EC 1.6.99.3) FT from Yarrowia lipolytica (Candida lipolytica) (281 aa), FT FASTA scores: opt: 356, E(): 1.1e-15, (34.55% identity in FT 162 aa overlap). Also similar to MTCY251.05, FASTA score: FT E():4.9e-05. Equivalent to AAK47574 from Mycobacterium FT tuberculosis strain CDC1551 but longer 26 aa. BELONGS TO FT THE COMPLEX I 30 KDA SUBUNIT FAMILY. TBparse score is FT 0.893." FT /db_xref="GOA:P65572" FT /db_xref="InterPro:IPR020396" FT /db_xref="UniProtKB/Swiss-Prot:P65572" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95263.1" FT /translation="MSPPNQDAQEGRPDSPTAEVVDVRRGMFGVSGTGDTSGYGRLVRQ FT VVLPGSSPRPYGGYFDDIVDRLAEALRHERVEFEDAVEKVVVYRDELTLHVRRDLLPRV FT AQRLRDEPELRFELCLGVSGVHYPHETGRELHAVYPLQSITHNRRLRLEVSAPDSDPHI FT PSLFAIYPTNDWHERETYDFFGIIFDGHPALTRIEMPDDWQGHPQRKDYPLGGIPVEYK FT GAQIPPPDERRGYN" FT CDS 25447..26769 FT /transl_table=11 FT /gene="nuoD" FT /locus_tag="Mb3172" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN D) NUOD FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN D)" FT /EC_number="1.6.5.3" FT /note="Mb3172, nuoD, len: 440 aa. Equivalent to Rv3148, FT len: 440 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 440 aa overlap). Probable nuoD, NADH FT dehydrogenase, chain B (EC 1.6.5.3), similar to others e.g. FT Q9XAQ7|NUOD from Streptomyces coelicolor (440 aa), FASTA FT scores: opt: 2198, E(): 1e-131, (73.9% identity in 429 aa FT overlap); P15689|NUCM_PARTE from Paramecium tetraurelia FT (400 aa), FASTA scores: opt: 922, E(): 5.8e-51, (38.5% FT identity in 408 aa overlap); Q9RU89|NUOD_DEIRA|DR1503 from FT Deinococcus radiodurans (401 aa), FASTA scores: opt: 922, FT E(): 5.8e-51, (47.75% identity in 404 aa overlap); etc. FT Equivalent to AAK47575 from Mycobacterium tuberculosis FT strain CDC1551 but longer 42 aa. Contains helix-turn-helix FT motif at aa 340-361. BELONGS TO THE COMPLEX I 49 KDA FT SUBUNIT FAMILY." FT /db_xref="GOA:P65570" FT /db_xref="InterPro:IPR014029" FT /db_xref="UniProtKB/Swiss-Prot:P65570" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95264.1" FT /translation="MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGP FT QHPSTHGVLRLILEIEGETVVEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPF FT FNETAYCLGVEKLLGITDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTPMFV FT GFRAREIVLTLFEKITGLRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGEL FT LNENAIWKARTQGVGYLDLTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVIT FT DDSCDAYGRYMIRVKEMWESMKIVEQCLDKLRPGPTMISDRKLAWPADLQVGPDGLGNS FT PKHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRV FT HYRDPSFTNLQSVAAMCEGGMVADLIAAVASIDPVMGGVDR" FT CDS 26766..27524 FT /transl_table=11 FT /gene="nuoE" FT /locus_tag="Mb3173" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN E) NUOE FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN E)" FT /EC_number="1.6.5.3" FT /note="Mb3173, nuoE, len: 252 aa. Equivalent to Rv3149, FT len: 252 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 252 aa overlap). Probable nuoE, NADH FT dehydrogenase, chain E (EC 1.6.5.3), similar to others e.g. FT Q9XAQ8|NUOE from Streptomyces coelicolor (290 aa), FASTA FT scores: opt: 1002, E(): 5.7e-55, (69.5% identity in 213 aa FT overlap); P40915|NUHM_NEUCR|NUO-24 from Neurospora crassa FT (263 aa), FASTA scores: opt: 412, E(): 1.9e-18, (38055% FT identity in 192 aa overlap); P19234|NUHM_RAT from Rattus FT norvegicus (Rat) (241 aa), FASTA scores: opt: 410, E(): FT 2.4e-18, (23.9% identity in 237 aa overlap); etc. BELONGS FT TO THE COMPLEX I 24 KDA SUBUNIT FAMILY. BINDS A 2FE-2S FT CLUSTER (POTENTIAL)." FT /db_xref="GOA:P65574" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/Swiss-Prot:P65574" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95265.1" FT /translation="MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAK FT EIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYRRR FT PTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACDYAP FT VVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEG FT QGGPGAPTLAGLQVARKNDMQAPPTPGADE" FT CDS 27521..28858 FT /transl_table=11 FT /gene="nuoF" FT /locus_tag="Mb3174" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN F) NUOF FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN F)" FT /EC_number="1.6.5.3" FT /note="Mb3174, nuoF, len: 445 aa. Equivalent to Rv3150, FT len: 445 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 445 aa overlap). Probable nuoF, NADH FT dehydrogenase, chain F (EC 1.6.5.3), similar to others e.g. FT Q9XAQ9|NUOF_STRCO from Streptomyces coelicolor (449 aa), FT FASTA scores: opt: 2314, E(): 3.5e-139, (76.25% identity in FT 434 aa overlap); NUF2_RHIME from Rhizobium meliloti (421 FT aa), FASTA scores: opt: 1545, E(): 1.8e-90, (53.1% identity FT in 424 aa overlap); Q9RU92|DR1500 from Deinococcus FT radiodurans (444 aa), FASTA scores: opt: 1445, E(): FT 4.1e-84, (52.9% identity in 427 aa overlap); etc. Contains FT respiratory-chain NADH dehydrogenase 51 Kd subunit FT signature 2 (PS00645). BELONGS TO THE COMPLEX I 51 KDA FT SUBUNIT FAMILY. COFACTOR: FMN AND ONE 4FE-4S CLUSTER FT (PROBABLE)." FT /db_xref="GOA:P65568" FT /db_xref="InterPro:IPR019554" FT /db_xref="UniProtKB/Swiss-Prot:P65568" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95266.1" FT /translation="MTTQATPLTPVISRHWDDPESWTLATYQRHDRYRGYQALQKALTM FT PPDDVISIVKDSGLRGRGGAGFATGTKWSFIPQGDTGAAAKPHYLVVNADESEPGTCKD FT IPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVVPVLRRLHNAVAEAYAAGFLGRNI FT GGSGFDLELVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNV FT ETIASVPSIILGGIDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAG FT GVRAGHRLKFWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDETTCVVRA FT VRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDISDSILGKSFC FT ALGDGAASPVMSSIKHFRDEYLAHVEGGGCPFDPRDSMLVANGVDA" FT CDS 28855..31275 FT /transl_table=11 FT /gene="nuoG" FT /locus_tag="Mb3175" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN G) NUOG FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN G)" FT /EC_number="1.6.5.3" FT /note="Mb3175, nuoG, len: 806 aa. Equivalent to Rv3151, FT len: 806 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 806 aa overlap). Probable nuoG, NADH FT dehydrogenase I, chain G (EC 1.6.5.3), similar to others FT e.g. Q9XAR0|NUOG_STRCO from Streptomyces coelicolor (843 FT aa), FASTA scores: opt: 1968 ,E(): 5.2e-107, (62.45% FT identity in 818 aa overlap); P56914|NUG2_RHIME from FT Rhizobium meliloti (853 aa), FASTA scores: opt: 964, E(): FT 1.6e-48, (30.6% identity in 840 aa overlap); etc. But also FT similarity with other proteins e.g. P77908|FDHA FORMATE FT DEHYDROGENASE, ALPHA SUBUNIT (EC 1.2.1.43) (FORMATE FT DEHYDROGENASE [NADP+]) from Moorella thermoacetica FT (Clostridium thermoaceticum) (893 aa), FASTA scores: opt: FT 928, E(): 2e-46, (28.65% identity in 865 aa overlap); and FT Q9UUU3|NUAM NUAM PROTEIN PRECURSOR (EC 1.6.99.3) from FT Yarrowia lipolytica (Candida lipolytica) (728 aa), FASTA FT scores: opt: 894, E(): 1.7e-44, (31.95% identity in 676 aa FT overlap). Equivalent to AAK47578 from Mycobacterium FT tuberculosis strain CDC1551 but longer 15 aa. Contains FT respiratory-chain NADH dehydrogenase 75 kDa subunit FT signature 2 (PS00642). BELONGS TO THE COMPLEX I 75 KDA FT SUBUNIT FAMILY. COFACTOR: MAY BIND TWO 4FE-4S CLUSTER AND FT ONE 2FE-2S CLUSTER. TBparse score is 0.887." FT /db_xref="GOA:P59962" FT /db_xref="InterPro:IPR010228" FT /db_xref="UniProtKB/Swiss-Prot:P59962" FT /protein_id="CAD95267.1" FT /translation="MTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQI FT PRFCDHPLLEPVGACRQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQHGVM FT ELLLINHPLDCPMCDKGGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLDRER FT CILCARCTRFSDQIAGDPFIDMQERGALQQVGIYADEPFESYFSGNTVQICPVGALTGT FT AYRFRARPFDLVSSPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCDKGRWA FT FTYATQPDVITTPLIRDGGDPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVGGRVTWE FT DAYAYAKFARITLGTNDIDFRARPHSAEEADFLAARIAGRHMAVSYADLESAPVVLLVG FT FEPEDESPIVFLRLRKAARRHRVPVYTIAPFATGGLHKMSGRLIKTVPGGEPAALDDLA FT TGAVGDLLATPGAVIMVGERLATVPGGLSAAARLADTTGARLAWVPRRAGERGALEAGA FT LPTLLPGGRPLADEVARAQVCAAWHIAELPAAAGRDADGILAAAADETLAALLVGGIEP FT ADFADPDAVLAALDATGFVVSLELRHSAVTERADVVFPVAPTTQKAGAFVNWEGRYRTF FT EPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGIWDGKHAAGPHIA FT ATGPTQPEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSPDTAAEIGAADGEA FT VTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGSIVKIGAGS" FT CDS 31391..32623 FT /transl_table=11 FT /gene="nuoH" FT /locus_tag="Mb3176" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN H) NUOH FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN H)" FT /EC_number="1.6.5.3" FT /note="Mb3176, nuoH, len: 410 aa. Equivalent to Rv3152, FT len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 410 aa overlap). Probable nuoH, FT integral membrane NADH dehydrogenase I, chain H (EC FT 1.6.5.3), similar to others e.g. Q9XAR1 Q9XAR1|NUOH from FT Streptomyces coelicolor (467 aa), FASTA scores: opt: 1630, FT E(): 3.4e-90, (58.35% identity in 413 aa overlap); FT Q9RU94|DR1498 from Deinococcus radiodurans (397 aa), FASTA FT scores: opt: 1081, E(): 2e-57, (45.5% identity in 391 aa FT overlap); Q9ZCF7|NUOH_RICPR|RP796 from Rickettsia FT prowazekii (339 aa), FASTA scores: opt: 976, E(): 3.4e-51, FT (46.2% identity in 329 aa overlap); etc. Contains FT respiratory-chain NADH dehydrogenase subunit 1 signature 2 FT (PS00668). Some similarity to MTCY251.02 (FASTA score: E(): FT 1.2e-07). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY." FT /db_xref="GOA:P65562" FT /db_xref="InterPro:IPR018086" FT /db_xref="UniProtKB/Swiss-Prot:P65562" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95268.1" FT /translation="MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRP FT GPNRVGPKGALQSLADGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFGPE FT VSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISY FT EVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLP FT EAEGELVAGFHTEYSSLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANT FT GWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVAAIIRSL FT RNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPL FT LAGATKENAGG" FT CDS 32616..33251 FT /transl_table=11 FT /gene="nuoI" FT /locus_tag="Mb3177" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN I) NUOI FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN I)" FT /EC_number="1.6.5.3" FT /note="Mb3177, nuoI, len: 211 aa. Equivalent to Rv3153, FT len: 211 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 211 aa overlap). Probable nuoI, NADH FT dehydrogenase I, chain I (EC 1.6.5.3), similar to others FT e.g. Q9XAR2|NUOI from Streptomyces coelicolor (211 aa), FT FASTA scores: opt: 825, E(): 9.3e-44, (70.1% identity in FT 164 aa overlap); Q56224|NQO9_THETH from Thermus aquaticus FT (subsp. thermophilus) (182 aa), FASTA scores: opt: 543, FT E(): 1.8e-26, (50.9% identity in 163 aa overlap); FT Q9RU95|DR1497 from Deinococcus radiodurans (178 aa), FASTA FT scores: opt: 527, E(): 1.7e-25, (48.75% identity in 162 aa FT overlap); etc. Contains two 4Fe-4S ferredoxins, iron-sulfur FT binding region signatures (PS00198). BELONGS TO THE COMPLEX FT I 23 KDA SUBUNIT FAMILY. THE IRON-SULFUR CENTERS ARE FT SIMILAR TO THOSE OF 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. FT COFACTOR: BINDS TWO 4FE-4S CLUSTERS." FT /db_xref="GOA:Q7TX57" FT /db_xref="HSSP:1FCA" FT /db_xref="InterPro:IPR010226" FT /db_xref="UniProtKB/Swiss-Prot:Q7TX57" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95269.1" FT /translation="MANTDRPALPHKRAVPPSRADSGPRRRRTKLLDAVAGFGVTLGSM FT FKKTVTEEYPERPGPVAARYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYVEGADNT FT EEERFSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTYDYELADDNRADLIYEKDR FT LLAPLLPEMAAPPHPRAPGATDKDYYLGNVTAEGLRGVRESQTTGDSR" FT CDS 33248..34036 FT /transl_table=11 FT /gene="nuoJ" FT /locus_tag="Mb3178" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN J) NUOJ FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN J)" FT /EC_number="1.6.5.3" FT /note="Mb3178, nuoJ, len: 262 aa. Equivalent to Rv3154, FT len: 262 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 262 aa overlap). Probable nuoJ, FT transmembrane NADH dehydrogenase I, chain J (EC 1.6.5.3), FT similar to others e.g. Q9XAR3|NUOJ from Streptomyces FT coelicolor (285 aa), FASTA scores: opt: 991, E(): 3.2e-52, FT (63.7% identity in 243 aa overlap); Q9JX90|NUOJ|NMA0006 FT from Neisseria meningitidis (serogroup A) (223 aa), FASTA FT scores: opt: 329, E(): 9.6e-13, (34.85% identity in 175 aa FT overlap); Q9K1B2|NMB0253 from Neisseria meningitidis FT (serogroup B) (223 aa), FASTA scores: opt: 326, E(): FT 1.5e-12, (34.85% identity in 175 aa overlap); etc. But also FT similarity with Q00243|NU6C_PLEBO|NDH6 NADH-PLASTOQUINONE FT OXIDOREDUCTASE CHAIN 6 HOMOLOG (EC 1.6.5.3) (CATALYTIC FT ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) FT from Plectonema boryanum (199 aa), FASTA scores: opt: 287, FT E(): 2.8e-10, (34.35% identity in 195 aa overlap). SIMILAR FT TO POLYPEPTIDE 6 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF FT CHLOROPLASTS OR MITOCHONDRIA." FT /db_xref="GOA:Q7TX56" FT /db_xref="InterPro:IPR001457" FT /db_xref="UniProtKB/TrEMBL:Q7TX56" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95270.1" FT /translation="MTAVLASDVIVRTSTGEAVMFWVLSALALLGAVGVVLAVNAVYSA FT MFLAMTMIILAVFYMAQDALFLGVVQVVVYTGAVMMLFLFVLMLIGVDSAESLKETLRG FT QRVAAVLTGVGFGVLLISTIGQVATRGFAGLTVANANGNVEGLAALIFSRYLWAFELTS FT ALLITAAVGAMVLAHRERFERRKTQRELSQERFRPGGHPTPLPNPGVYARHNAVDVAAL FT LPDGSYSELSVPRMLRTRGADGLQTPSPGAVSGSLEGGAS" FT CDS 34033..34332 FT /transl_table=11 FT /gene="nuoK" FT /locus_tag="Mb3179" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN K) NUOK FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN K)" FT /EC_number="1.6.5.3" FT /note="Mb3179, nuoK, len: 99 aa. Equivalent to Rv3155, len: FT 99 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 99 aa overlap). Probable nuoK, integral FT membrane NADH dehydrogenase I, chain K (EC 1.6.5.3), FT similar to others e.g. Q9XAR4|NUOK from Streptomyces FT coelicolor (99 aa), FASTA scores: opt: 509, E(): 2.7e-31, FT (78.55% identity in 98 aa overlap); Q56226|NQOB_THETH|NQO11 FT from Thermus aquaticus (subsp. thermophilus) (95 aa), BLAST FT scores: initn: 298, init1: 180, bits: 85.7, FASTA scores: FT opt: 313, E(): 9.4e-17, (53.7% identity in 95 aa overlap); FT Q9RU97|DR1495 from Deinococcus radiodurans (103 aa), FASTA FT scores: opt: 309, E(): 2e-16, (52.0% identity in 100 aa FT overlap); etc. But also similarity with NADH-PLASTOQUINONE FT OXIDOREDUCTASES CHAIN 4L e.g. Q9MUL4|NULC_MESVI|NDHE from FT Mesostigma viride (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + FT PLASTOQUINONE = NAD(+) + PLASTOQUINOL) (101 aa), FASTA FT scores: opt: 280, E(): 2.8e-14, (40.6% identity in 101 aa FT overlap); and P06261|NULC_TOBAC|NDHE|NDH4L from Nicotiana FT tabacum (Common tobacco) (101 aa), FASTA scores: opt: 259, FT E(): 1e-12, (43.0% identity in 93 aa overlap). SIMILAR TO FT POLYPEPTIDE 4L OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF FT CHLOROPLASTS OR MITOCHONDRIA." FT /db_xref="GOA:P65566" FT /db_xref="InterPro:IPR001133" FT /db_xref="UniProtKB/Swiss-Prot:P65566" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95271.1" FT /translation="MNPANYLYLSVLLFTIGASGVLLRRNAIVMFMCVELMLNAVNLAF FT VTFARMHGHLDAQMIAFFTMVVAACEVVVGLAIIMTIFRTRKSASVDDANLLKG" FT CDS 34343..36244 FT /transl_table=11 FT /gene="nuoL" FT /locus_tag="Mb3180" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN L) NUOL FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN L)" FT /EC_number="1.6.5.3" FT /note="Mb3180, nuoL, len: 633 aa. Equivalent to Rv3156, FT len: 633 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 633 aa overlap). Probable nuoL, integral FT membrane NADH dehydrogenase I, chain L (EC 1.6.5.3), FT similar to others e.g. Q9XAR5|NUOL_STRCO from Streptomyces FT coelicolor (654 aa), FASTA scores: opt: 2074, E(): FT 1.1e-111, (61.1% identity in 648 aa overlap); FT Q56227|NQOC_THETH|NQO12 from Thermus aquaticus (subsp. FT thermophilus) (606 aa), FASTA scores: opt: 1420, E(): FT 3.8e-74, (43.35% identity in 630 aa overlap); FT Q9ZJV6|NUOL|JHP1192 from Helicobacter pylori J99 FT (Campylobacter pylori J99) (612 aa), FASTA scores: opt: FT 1279, E(): 4.7e-66, (41.65% identity in 516 aa overlap); FT etc. Also similar to MTCY251.04 (FASTA score: E(): 1.3e-11) FT and MTCY03A2.01c (FASTA score: E(): 2.3e-10). SIMILAR TO FT POLYPEPTIDE 5 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF FT CHLOROPLASTS OR MITOCHONDRIAL." FT /db_xref="GOA:Q7TX55" FT /db_xref="InterPro:IPR003916" FT /db_xref="UniProtKB/TrEMBL:Q7TX55" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95272.1" FT /translation="MTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALA FT AFGVGAMLLADMLGRDGLERAIHQQVFTWIPAGGLQVDFGLQIDQLSMCFVLLISGVGS FT LIHIYSVGYMAEDPDRRRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLLIGF FT WYHKPSAATAAKKAFVMNRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAI FT GLLMLLGACAKSAQVPLQAWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAP FT TAQLAVVIVGAVTLLYGAIIGCAKDDIKRALAASTISQIGYMVLAAGLGPAGYAFAIMH FT LLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFA FT GFFSKDAIIEAALGAGGIRGSLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPH FT EAPAVMTWPMILLAVGSVFSGGLLAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALG FT VVAVGIAVAYRMYGTAPIPRVAPVRVSALTAAARADLYGDAFNEEVFMRPGAQLTNAVV FT AVDDAGVDGSVNALATLVSQTSNRLRQMQTGFARNYALSMLVGAVLVAAALLVVQLW" FT CDS 36241..37902 FT /transl_table=11 FT /gene="nuoM" FT /locus_tag="Mb3181" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN M) NUOK FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN M)" FT /EC_number="1.6.5.3" FT /note="Mb3181, nuoM, len: 553 aa. Equivalent to Rv3157, FT len: 553 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 553 aa overlap). Probable nuoM, integral FT membrane NADH dehydrogenase I, chain M (EC 1.6.5.3), FT similar to others e.g. Q9XAR6|NUOM from Streptomyces FT coelicolor (523 aa), FASTA scores: opt: 1621, E(): 4.2e-89, FT (56.55% identity in 541 aa overlap); P50974|NUOM_RHOCA|NUOM FT from Rhodobacter capsulatus (Rhodopseudomonas capsulata) FT (512 aa), FASTA scores: opt: 996, E(): 6.5e-52, (38.2% FT identity in 521 aa overlap); P29925|NQOD_PARDE|NQO13 from FT Paracoccus denitrificans (513 aa), FASTA scores: opt: 987, FT E(): 2.2e-51, (37.05% identity in 540 aa overlap); etc. FT Also similar to MTCY251.04 (FASTA score: E(): 3.3e-16) and FT MTCY03A2.02c (FASTA score: E(): 9.6e-13). SIMILAR TO FT POLYPEPTIDE 4 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF FT CHLOROPLASTS OR MITOCHONDRIAL." FT /db_xref="GOA:Q7TX54" FT /db_xref="InterPro:IPR010227" FT /db_xref="UniProtKB/TrEMBL:Q7TX54" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95273.1" FT /translation="MNNVPWLSVLWLVPLAGAVLIILLPPGRRRLAKWAGMVVSVLTLA FT VSIVVAAEFKPSAEPYQFVEKHSWIPAFGAGYTLGVDGIAVVLVLLTTVLIPLLLVAGW FT NDATDADDLSPASGRYPQRPAPPRLRSSGGERTRGVHAYVALTLAIESMVLMSVIALDV FT LLFYVFFEAMLIPMYFLIGGFGQGAGRSRAAVKFLLYNLFGGLIMLAAVIGLYVVTAQY FT DSGTFDFREIVAGVAAGRYGADPAVFKALFLGFMFAFAIKAPLWPFHRWLPDAAVESTP FT ATAVLMMAVMDKVGTFGMLRYCLQLFPDPSTYFRPLIVTLAIIGVIYGAIVAIGQTDMM FT RLIAYTSISHFGFIIAGIFVMTTQGQSGSTLYMLNHGLSTAAVFLIAGFLIARRDSRSI FT ADYGGVQKVAPILAGTFMVSAMATVSLPGLAPFISEFLVLLGTFSRYWLAAAFGVTALV FT LSAVYMLWLYQRVMTGPIAEGNERIGDLVGREMIVVAPLIALLLVLGVYPKPVLDIINP FT AVENTMTTIGQHDPAPSVAHPVPAVGASRTAEGPHP" FT CDS 37899..39494 FT /transl_table=11 FT /gene="nuoN" FT /locus_tag="Mb3182" FT /product="PROBABLE NADH DEHYDROGENASE I (CHAIN N) NUON FT (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN N)" FT /EC_number="1.6.5.3" FT /note="Mb3182, nuoN, len: 531 aa. Equivalent to Rv3158, FT len: 531 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 531 aa overlap). Probable nuoN, FT integral membrane NADH dehydrogenase I, chain N (EC FT 1.6.5.3), similar to others e.g. Q9XAR7|SC10A7.08c from FT Streptomyces coelicolor (552 aa), FASTA scores: opt: 1493, FT E(): 1.1e-81, (56.7% identity in 543 aa overlap); FT Q9PGI2|XF0318 from Xylella fastidiosa (485 aa), FASTA FT scores: opt: 942, E(): 7.4e-49, (39.6% identity in 379 aa FT overlap); CAB51628|NUON2 from Rhizobium meliloti FT (Sinorhizobium meliloti) (479 aa), FASTA scores: opt: 934, FT E(): 2.2e-48, (35.5% identity in 479 aa overlap); etc. But FT also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES FT CHAIN 4L (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + FT PLASTOQUINONE = NAD(+) + PLASTOQUINOL) e.g. FT P29801|NU2C_SYNP7|NDHB from Synechococcus sp. strain PCC FT 7942 (Anacystis nidulans R2) (521 aa), FASTA scores: opt: FT 921, E(): 1.4e-47, (40.25% identity in 395 aa overlap). FT BELONGS TO THE COMPLEX I SUBUNIT 2 FAMILY." FT /db_xref="GOA:P0A5M1" FT /db_xref="InterPro:IPR001750" FT /db_xref="UniProtKB/Swiss-Prot:P0A5M1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95274.1" FT /translation="MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTL FT ALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERS FT ARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSVGGM FT MVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGV FT ALLYGATGTLTLPGIRDALAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGA FT PTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTN FT VKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSA FT GSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLV FT IVGVISSGVAAYFYVRVIVSMFFTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQ FT PVLDLADQAAQLLR" FT CDS complement(39500..41269) FT /transl_table=11 FT /gene="PPE53" FT /locus_tag="Mb3183c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3183c, PPE53, len: 589 aa. Equivalent to Rv3159c, FT len: 590 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 590 aa overlap). Member of the FT Mycobacterium tuberculosis PPE_family of Gly-, Asn-rich FT proteins. Highly similar to P71868|Rv3533c|MTCY03C7.23 (582 FT aa), FASTA scores: opt: 2289, E(): 3.2e-98, (63.5% identity FT in 600 aa overlap); and also similar to MTCY48_17, FT MTV041_29, MTCY6G11_5, MTCY98_24, etc. TBparse score is FT 0.921. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, albeit a 2143 bp insertion occurs overlapping the FT NH2-terminal part, this leads to an equivalent product, FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7TX53" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95275.1" FT /translation="MNYSVLPPEINSLRMFTGAGSAPMLAASVAWDRLAAELAVAASSF FT GSVTSGLAGQSWQGAAAAMAAAAAPYAGWLAAAAARAAGASAQAKAVASAFEAARAATV FT HPMLVAANRNAFVQLVLSNLFGQNAPAIAAAEAMYEQMWAADVAAMVGYHGGASAAAAQ FT LSSWSIGLQQALPAAPSALAAAIGLGNIGVGNLGGGNTGEYNLGSGNSGNANVGSGNSG FT NANVGSGNDGATNLGSGNIGNTNLGSGNVGNVNLGSGNRGFGNLGNGNFGSGNLGSGNT FT GSTNFGGGNLGSFNLGSGNIGSSNIGFGNNGDNNLGLGNNGNNNIGFGLTGDNLVGIGA FT LNSGIGNLGFGNSGNNNIGFFNSGNNNVGFFNSGNNNFGFGNAGDINTGFGNAGDTNTG FT FGNAGFFNMGIGNAGNEDMGVGNGGSFNVGVGNAGNQSVGFGNAGTLNVGFANAGSINT FT GFANSGSINTGGFDSGDRNTGFGSSVDQSVSSSGFGNTGMNSSGFFNTGNVSAGYGNNG FT DVQSGINNTNSGGFNVGFYNSGAGTVGIANSGLQTTGIANSGTLNTGVANTGDHSSGGF FT NQGSDQSGFFGQP" FT CDS complement(41517..43415) FT /transl_table=11 FT /gene="PPE70" FT /locus_tag="Mb3184c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb3184c, PPE70, len: 685 aa. Equivalent to MT3248, FT len: 686 aa, from Mycobacterium tuberculosis strain FT CDC1551, (99.708% identity in 686 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an FT insertion of 2143 bp exists between PPE53 and Rv3160c FT compared to Mycobacterium tuberculosis strain H37Rv. This FT leads to a additional gene, PPE70 equivalent to MT3248 from FT Mycobacterium tuberculosis strain CDC1551." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7TX52" FT /protein_id="CAD95276.1" FT /translation="MNYSVLPPEINSLRMFTGAGSAPMLAASVAWDGLAAELAVAASSF FT GSVTSGLAGQSWQGAAAAMAAAAAPYAGWLAAAAARAAGASAQAKAVASAFEAARAATV FT HPMLVAANRNAFVQLVLSNLFGQNAPAIAAAEAMYEQMWAADVAAMVGYHGGASAAAAA FT LPSWQQALRGLPGLGQVASAISGGAASMFAAPAAATAAVTPPALNTGLGNIGSWNLGGG FT NVGLLNLGSGNFGSLNLGGGNTGNANLGGGNWGFANLGSGNIGNTNFGNGNQGNLNFGS FT GNLLGNGNFGFGNAFGDGNLGSGNVGSTNLGSGNFGSFNVGSGNMGMSNIGFGNLGNNN FT LGFGNNGNNNIGFGLTGDNLVGIGALNSGIGNMGFGNSGNNNIGFFNSGNGNVGFFNSG FT DGNTGFGNAGDVNTGFWNGGPFNTGFGNGGNTNFGFGNAGFQNMGHGNAGGVNVGSGNA FT GLANTGDFNSGGVVSGIGGNTGSFNSGNLNTGFGNAGDLNTGLFNSGDVNTGIGSTVDQ FT PGSVSGFGNTGTSVSGFNNSGNLTSGFGNMNSNVFDSTSGFQNIGDANVGFFNSGNSNE FT GFFNTGMFNNGIYNSGVASTGIANSGNASSGVANSGDNSSGAFNQGDNQAGFFGQP" FT CDS complement(43590..44231) FT /transl_table=11 FT /gene="Mb3185c" FT /locus_tag="Mb3185c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /note="Mb3185c, -, len: 213 aa. Equivalent to Rv3160c, len: FT 213 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 213 aa overlap). Possible FT transcriptional regulator, with some similarity to others FT e.g. Q9S3L4|AMTR AMTR PROTEIN (global repressor in the FT nitrogen regulation system; see first citation below for FT more information) (222 aa), FASTA scores: opt: 182, E(): FT 7.3e-05, (27.9% identity in 208 aa overlap); FT Q9X7X9|SC6A5.33c PUTATIVE REGULATORY PROTEIN from FT Streptomyces coelicolor (223 aa), FASTA scores: opt: 176, FT E(): 0.00018, (26.5% identity in 185 aa overlap); FT Q9XA31|SCH69.03c PUTATIVE TRANSCRIPTIONAL REGULATOR from FT Streptomyces coelicolor (209 aa), FASTA scores: opt: 173, FT E(): 0.00027, (27.25% identity in 176 aa overlap); FT BAB54133|MLL7734 TRANSCRIPTIONAL REGULATOR from Rhizobium FT loti (Mesorhizobium loti) (213 aa), FASTA scores: opt: 172, FT E(): 0.00031, (23.55% identity in 204 aa overlap); etc. FT Also similar to hypothetical proteins from Mycobacterium FT tuberculosis strain H37Rv e.g. P96839|Rv3557v|MTCY06G11.04c FT (200 aa), FASTA scores: opt: 169, E(): 0.00046, (26.75% FT identity in 157 aa overlap). Contains probable FT helix-turn-helix motif from aa 31 to 52 (Score 1857, +5.51 FT SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL FT REGULATORS. TBparse score is 0.901." FT /db_xref="GOA:Q7TX51" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7TX51" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95277.1" FT /translation="MPRQAGRWSPTALRILGAAAELIALRGYSSTSTRDIAAAVGVEQP FT AIYKHFSAKRDILAALVRLAVEWPLELFGHITAMPVPAVVKLHRWLTESLDHLHASPYV FT LVSILITPDLHQESFVAERELVAEMERALVGLIETGQGEGDVRAMHPLSAARLVQALFD FT ALALPEFAVSPDEIVEFAMTALLSDPDRLAEIRAAADALEIQTAPPDRGL" FT CDS complement(44242..45390) FT /transl_table=11 FT /gene="Mb3186c" FT /locus_tag="Mb3186c" FT /product="POSSIBLE DIOXYGENASE" FT /EC_number="1.-.-.-" FT /note="Mb3186c, -, len: 382 aa. Equivalent to Rv3161c, len: FT 382 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 382 aa overlap). Possible dioxygenase FT (EC 1.-.-.-), similar to subunit of several dioxygenases FT and related proteins e.g. BAB50510|MLR3662 DIOXYGENASE, FT ALPHA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (400 FT aa), FASTA scores: opt: 413, E(): 6.2e-20, (28.4% identity FT in 331 aa overlap); Q9A3T0|CC3122 RIESKE 2FE-2S FAMILY FT PROTEIN from Caulobacter crescentus (404 aa), FASTA scores: FT opt: 405, E(): 2.1e-19, (27.95% identity in 372 aa FT overlap); Q9HTF4|PA5410 PROBABLE RING HYDROXYLATING FT DIOXYGENASE, ALPHA-SUBUNIT from Pseudomonas aeruginosa (429 FT aa), FASTA scores: opt: 392, E(): 1.6e-18, (25.8% identity FT in 399 aa overlap); Q9AGK6|PHTAA PHTHALATE DIOXYGENASE FT LARGE SUBUNIT from Arthrobacter keyseri (473 aa), FASTA FT scores: opt: 385, E(): 5.2e-18, (34.0% identity in 206 aa FT overlap); P76253|YEAW_ECOLI PUTATIVE DIOXYGENASE, ALPHA FT SUBUNIT from Escherichia coli (374 aa), FASTA scores: opt: FT 376, E(): 1.7e-17, (27.05% identity in 344 aa overlap); FT etc. TBparse score is 0.932." FT /db_xref="GOA:Q7TX50" FT /db_xref="InterPro:IPR017941" FT /db_xref="UniProtKB/TrEMBL:Q7TX50" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95278.1" FT /translation="MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQLER FT ERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDGQLHALSPICRHRLMLMVE FT PGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDFNRRECRLPQFAVATWNGLVWINL FT DADAEPIAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHENYHVLGLHRQ FT TLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKSNLVVLWTFPNSALA FT IAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDEDRLGLEA FT VQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS" FT CDS complement(45306..45896) FT /transl_table=11 FT /gene="Mb3187c" FT /locus_tag="Mb3187c" FT /product="POSSIBLE INTEGRAL MEMBRANE PROTEIN" FT /note="Mb3187c, -, len: 196 aa. Similar to 5' end of FT Rv3162c, len: 145 aa, from Mycobacterium tuberculosis FT strain H37Rv, (86.7% identity in 98 aa overlap). Possible FT integral membrane protein, with some similarity to FT C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical FT protein from Mycobacterium tuberculosis (287 aa), FASTA FT scores: opt: 112, E(): 6.9, (29.65% identity in 135 aa FT overlap); and other hypothetical proteins from other FT organisms. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a frameshift due to a single base deletion (t-*), FT leads to a longer product with different COOH part compared FT to its homolog in Mycobacterium tuberculosis strain H37Rv." FT /db_xref="UniProtKB/TrEMBL:Q7TX49" FT /protein_id="CAD95279.1" FT /translation="MTSFAHPGTRGLSTVFGLMMVGSAAVGSHGLAVVVGLAAVIAVGV FT AAVFRLAATLAVVLSVVMIVVSGPTHVLAALSGFAPPSTWCADTGPVLSPGAGRRPLPP FT LVSRSLGWLRRRSRCKCHGCRWRHRWPCWLPTCWPPVRSRGEPPAGRSGRCALLTIGYQ FT SITWRVCYQLITEPSSETSLPTSGITSTTIHRR" FT CDS complement(45893..47164) FT /transl_table=11 FT /gene="Mb3188c" FT /locus_tag="Mb3188c" FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT /note="Mb3188c, -, len: 423 aa. Equivalent to Rv3163c, len: FT 423 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 423 aa overlap). Possible conserved FT secreted protein, with some similarity to other FT hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from FT Streptomyces coelicolor (460 aa), FASTA scores: opt: 666, FT E(): 1.5e-33, (33.55% identity in 417 aa overlap); FT O58486|PH0774 from Pyrococcus horikoshii (410 aa), FASTA FT scores: opt: 329, E(): 6.9e-13, (23.8% identity in 424 aa FT overlap); Q9UZ66|PAB0849 from Pyrococcus abyssi (410 aa), FT FASTA scores: opt: 322, E(): 1.9e-12, (24.15% identity in FT 389 aa overlap); etc. Also some similarity with FT P71761|Rv1480|MTV007.27|MTCY277.01 from Mycobacterium FT tuberculosis (317 aa), FASTA scores: opt: 198, E(): FT 6.3e-05, (26.75% identity in 269 aa overlap). Contains FT PS00402 Binding-protein-dependent transport systems inner FT membrane comp signature." FT /db_xref="InterPro:IPR002881" FT /db_xref="UniProtKB/TrEMBL:Q7TX48" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95280.1" FT /translation="MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAAP FT LLGVLCSISWQRPVPVIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALAGM FT QFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPLTPP FT QSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTRR FT LTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGGNRPRW FT LGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTEFALALI FT ELRKRGHVVVAVDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSL FT QQSMGALPNRRRRGRGRASRARLP" FT CDS complement(47194..48156) FT /transl_table=11 FT /gene="moxR3" FT /locus_tag="Mb3189c" FT /product="PROBABLE METHANOL DEHYDROGENASE TRANSCRIPTIONAL FT REGULATORY PROTEIN MOXR3" FT /note="Mb3189c, moxR3, len: 320 aa. Equivalent to Rv3164c, FT len: 320 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 320 aa overlap). Probable moxR3, FT methanol dehydrogenase regulatory protein, highly similar FT to Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from FT Streptomyces coelicolor (332 aa), FASTA scores: opt: 1227, FT E(): 1.7e-67, (60.25% identity in 302 aa overlap); FT Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY FT PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: FT 1126, E(): 2.3e-61, (54.1% identity in 305 aa overlap); FT Q9HSH7|MOXR|VNG0223G METHANOL DEHYDROGENASE REGULATORY FT PROTEIN from Halobacterium sp. strain NRC-1 (318 aa), FASTA FT scores: opt: 1072, E(): 4.5e-58, (51.45% identity in 315 aa FT overlap); Q9RVV4|DR0918 MOXR-RELATED PROTEIN from FT Deinococcus radiodurans (354 aa), FASTA scores: opt: 1000, FT E(): 1.2e-53, (50.95% identity in 318 aa overlap); etc. FT Also high similarity with several hypothetical bacterial FT proteins." FT /db_xref="GOA:Q7TX47" FT /db_xref="InterPro:IPR016366" FT /db_xref="UniProtKB/TrEMBL:Q7TX47" FT /protein_id="CAD95281.1" FT /translation="MIMPAATTTAHCEAVLDEIGRVVVGKRSALTLILTAVLARGHVLI FT EDLPGLGKTLIARSFAAALGLDFTRVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFT FT NLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTYPLP FT EAQLDRFAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVEQVTV FT HEDVLHYVVSLANATRHHPQVAVGASPRAELDLVQLSRARALLLGRDYVIPEDVKELAT FT AAVAHRITLRPEMWVRKIAGADVVSELLRRLPVPRISGT" FT CDS complement(48164..48646) FT /transl_table=11 FT /gene="Mb3190c" FT /locus_tag="Mb3190c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3190c, -, len: 160 aa. Equivalent to Rv3165c, len: FT 160 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 160 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TX46" FT /protein_id="CAD95282.1" FT /translation="MKRLIALGIFLIVGIELLALILHDRRLVLAGSGLALALVLLNVRR FT MLGNRDELTAAPDSDDLGEGLRRWLSNTETTIRWSESTRADWDRHLRPMLARRFEIATG FT HRQAKDPVAFAATGRMLFGDELWEWVNPNNVTHTGDRQPGPGRAALEEILQKLEQV" FT CDS complement(48643..49602) FT /transl_table=11 FT /gene="Mb3191c" FT /locus_tag="Mb3191c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3191c, -, len: 319 aa. Equivalent to Rv3166c, len: FT 319 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 319 aa overlap). Probable transmembrane FT protein, similar but longer (52 aa) to O32895|MLCB1779.35c FT hypothetical protein from Mycobacterium leprae (119 aa), FT FASTA scores: opt: 289, E(): 3.7e-10, (44.25% identity in FT 122 aa overlap). Also some similarity to Q9Z536|SC9B2.23c FT PUTATIVE TRANSMEMBRANE PROTEIN from Streptomyces coelicolor FT (339 aa), FASTA scores: opt: 247, E(): 2.5e-07, (28.2% FT identity in 326 aa overlap); and in N-terminus to FT Q9RS20|DR2307 PUTATIVE MULTIDRUG-EFFLUX TRANSPORTER from FT Deinococcus radiodurans (410 aa), FASTA scores: opt: FT 135,E(): 1, (32.35% identity in 136 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TX45" FT /protein_id="CAD95283.1" FT /translation="MPGTKPGSDKPTGRVVVVIVLLMLAGAALRGHLPADDGAPLAAAG FT GSRAALMFIVAALAATLALIALAIITRLRHPLPVAPSAGELSAMLGGAAGRPNWRVLLL FT GLGTILAWLLIAILLARLFVPDDVGPAAPIPDSTATPDASSTTPSRPQPPQDNNDDVLG FT ILFASTIGLFLMVVAGSLITSRRQRKSAPARISGDRIESPAPSARSESLARAAEIGLAE FT MADLRREPREAIIACYVAMERELSHVPGVAPQDFDTPTEVLARAVEHRALHGASAAALV FT SLFAEARFSPHVMNEEHREVAMRLLRLVLDELSTRTAI" FT CDS complement(49682..50308) FT /transl_table=11 FT /gene="Mb3192c" FT /locus_tag="Mb3192c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /note="Mb3192c, -, len: 208 aa. Equivalent to Rv3167c, len: FT 208 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 208 aa overlap). Probable FT transcriptional regulator, tetR family, similar to several FT transcriptional regulators e.g. Q9L2A4|SC8F4.22c (TETR/ACRR FT FAMILY) from Streptomyces coelicolor (234 aa), FASTA FT scores: opt: 317, E(): 7.5e-13, (33.35% identity in 210 aa FT overlap); Q9RK47|SCF12.11 (TETR/ACRR FAMILY) from FT Streptomyces coelicolor (206 aa), FASTA scores: opt: 293, FT E(): 2.1e-11, (32.65% identity in 199 aa overlap); Q54288 FT REGULATOR OF ANTIBIOTIC TRANSPORT COMPLEXES (TETR/ACRR FT FAMILY) (204 aa), FASTA scores: opt: 260, E(): 2.4e-09, FT (30.75% identity in 205 aa overlap); etc. Equivalent to FT AAK47595 from Mycobacterium tuberculosis strain CDC1551 but FT shorter 21 aa. Contains probable helix-turn-helix motif FT from aa 42 to 63 (Score 1727, +5.07 SD). MAY BE BELONG TO FT THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7TX44" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7TX44" FT /protein_id="CAD95284.1" FT /translation="MKADLPSLDKAPGAGRPRDPRIDSAILSATAELLVQIGYSNLSLA FT AVAERAGTTKSALYRRWSSKAELVHEAAFPAAPTALQAAAGDIAADIRMMIAATRDVFT FT TPVVRAALPGLVADMTADAELNARVLARFADLFAAVRMRLREAVDRGEAHPDVDPDRLI FT ELIGGATMLRMLLYPDDMLDDAWVDQTTAIVVRGVHRAAPGGSVV" FT CDS 50353..51489 FT /transl_table=11 FT /gene="Mb3193" FT /locus_tag="Mb3193" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3193, -, len: 378 aa. Equivalent to Rv3168, len: FT 378 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 378 aa overlap). Conserved hypothetical FT protein, similar to other hypothetical proteins e.g. FT Q9M7Y6|F3E22.6 from Arabidopsis thaliana (Mouse-ear cress) FT (314 aa), FASTA scores: opt: 236, E(): 1.1e-07, (27.35% FT identity in 234 aa overlap); Q9RYW2|DRA0194 from FT Deinococcus radiodurans (386 aa), FASTA scores: opt: 207, FT E(): 9.1e-06, (23.45% identity in 320 aa overlap); etc. FT Also some similarity with O69727|Rc3761c|MTV025.109c FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (351 FT aa), FASTA scores: opt: 193, E(): 6.4e-05, (29.4% identity FT in 242 aa overlap)." FT /db_xref="InterPro:IPR002575" FT /db_xref="UniProtKB/TrEMBL:Q7TX43" FT /protein_id="CAD95285.1" FT /translation="MANEPAIGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAPEVTV FT ESGVDSTGMSSETIILTARRQQDGRSIQQKLVARVAPAAEDVPVFPTYRLDHQFEVIRL FT VGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAERQR FT QLQDATVAALATLHSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIGRSPL FT LERTFEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWEMVALGPRELDVA FT WMIFAHRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVMWACV FT FMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH" FT CDS 51489..52613 FT /transl_table=11 FT /gene="Mb3194" FT /locus_tag="Mb3194" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3194, -, len: 374 aa. Equivalent to Rv3169, len: FT 374 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 374 aa overlap). Conserved hypothetical FT protein, with similarity to other hypothetical proteins: FT Q9A8W6|CC1232 from Caulobacter crescentus (368 aa), FASTA FT scores: opt: 669, E(): 3.3e-34, (34.05% identity in 376 aa FT overlap); and O32901|MLCB1779.41 from Mycobacterium leprae FT (127 aa), FASTA scores: opt: 179, E(): 0.00034, (29.0% FT identity in 131 aa overlap). Also weak similarity with FT P95149|Rv1866|MTCY359.07c (804 aa), FASTA scores: opt: 121, FT E(): 6.4, (37.0% identity in 119 aa overlap). Equivalent to FT AAK47597 from Mycobacterium tuberculosis strain CDC1551 but FT shorter 43 aa." FT /db_xref="UniProtKB/TrEMBL:Q7TX42" FT /protein_id="CAD95286.1" FT /translation="MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGNI FT FLITGIGYYPNLGVKDAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLRKL FT RIVLDETEGVAADLTWEGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVDGER FT IAVDPATWLGSRDRSWGIRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLIIQEE FT PDGFRSLNDCTRIWRDGHVEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVHFDVES FT KLAVPTHVGGGYGGDSDWSHGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHVGRALCR FT DGDGNPVQGWGLFEHGALGRHDPSGFADWSTLAP" FT CDS 52756..54102 FT /transl_table=11 FT /gene="aofH" FT /locus_tag="Mb3195" FT /product="PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH FT (AMINE OXIDASE) (MAO)" FT /EC_number="1.4.3.4" FT /note="Mb3195, aofH, len: 448 aa. Equivalent to Rv3170, FT len: 448 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 448 aa overlap). Probable aofH, FT flavin-containing (mono)amine oxidase (EC 1.4.3.4), similar FT to many eukaryotic monoamine oxidases e.g. P49253|AOF_ONCMY FT from Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) FT (522 aa), FASTA scores: opt: 869, E(): 5.3e-44, (37.7% FT identity in 448 aa overlap); P21396|AOFA_RAT|MAOA from FT Rattus norvegicus (Rat) (526 aa), FASTA scores: opt: 839, FT E(): 3.2e-42, (37.45% identity in 446 aa overlap); FT Q99NA8|MAO-A from Cavia porcellus (Guinea pig) (506 aa), FT FASTA scores: opt: 836, E(): 4.6e-42, (37.0% identity in FT 446 aa overlap); P21398|AOFA_BOVIN from Bos taurus (Bovine) FT (527 aa), FASTA scores: opt: 806, E(): 2.8e-40, (37.0% FT identity in 446 aa overlap); P21397|AOFA_HUMAN (527 aa), FT FASTA scores: opt: 801, E(): 5.6e-40, (37.2% identity in FT 446 aa overlap); etc. Alternative start possible at FT position 3538487. BELONGS TO THE FLAVIN MONOAMINE OXIDASE FT FAMILY. COFACTOR: FAD (POTENTIAL)." FT /db_xref="GOA:P63534" FT /db_xref="HSSP:1GOS" FT /db_xref="InterPro:IPR002937" FT /db_xref="UniProtKB/Swiss-Prot:P63534" FT /protein_id="CAD95287.1" FT /translation="MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGR FT SLTGRVAGVPADMGGSFIGPTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGT FT IPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATSSSR FT NLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQDRVPGGTQQIAQAA FT AAQLGARVLLNAAVRRIDRHGAGVTVTSDQGQAEAGFVIVAIPPAHRVAIEFDPPLPPE FT YQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFITFDVSPHADGPGILMG FT FVDARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPG FT SWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAAAEVAALL" FT CDS complement(54097..54996) FT /transl_table=11 FT /gene="hpx" FT /locus_tag="Mb3196c" FT /product="POSSIBLE NON-HEME HALOPEROXIDASE HPX" FT /EC_number="1.11.1.-" FT /note="Mb3196c, hpx, len: 299 aa. Equivalent to Rv3171c, FT len: 299 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 299 aa overlap). Possible hpx, non-heme FT haloperoxidase (EC 1.11.1.-), similar to other hydrolases FT (principaly epoxide hydrolases) and non-heme FT chloroperoxidases e.g. Q9RKB6|SCE87.22c PUTATIVE HYDROLASE FT from Streptomyces coelicolor (314 aa), FASTA scores: opt: FT 431, E(): 6e-20, (38.05% identity in 297 aa overlap); FT Q9HZ14|PA3226 PROBABLE HYDROLASE (SIMILAR TO ALPHA/BETA FT HYDROLASE FOLD) from Pseudomonas aeruginosa (275 aa), FASTA FT scores: opt: 236, E(): 1e-07, (29.6% identity in 277 aa FT overlap); Q9DBL9|1300003 D03RIK PROTEIN SIMILAR TO FT ALPHA/BETA HYDROLASE FOLD from Mus musculus (Mouse) (351 FT aa), FASTA scores: opt: 223, E(): 8.3e-07, (24.35% identity FT in 304 aa overlap); AAK46260|MT1988 EPOXIDE HYDROLASE from FT Mycobacterium tuberculosis strain CDC1551 (356 aa), FASTA FT scores: opt: 223, E(): 8.4e-07, (40.7% identity in 113 aa FT overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME FT CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) from FT Streptomyces lividans (275 aa), FASTA scores: opt: 220, FT E(): 1e-06, (29.5% identity in 305 aa overlap); etc. FT Equivalent to AAK47599 Hydrolase, alpha/beta hydrolase FT family from Mycobacterium tuberculosis strain CDC1551 but FT shorter 24 aa. Start chosen by similarity, alternative with FT good RBS possible." FT /db_xref="GOA:Q7TX41" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7TX41" FT /protein_id="CAD95288.1" FT /translation="MTVRAADGTPLHTQVFGPPHGYPIVLTHGFVCAIRAWAYQIADLA FT GDYRVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAGHSMGGITI FT AAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELSPVRVLAGRSLVNTFGGF FT PLPGAARALSRHVISTLAVAADADPSATRLVYELFTQMSAAGRGGCAKMLVEEVGSAHL FT NLDGLTVPTLVIGGVRDRLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHL FT RALAESVTRHVRDRRISS" FT CDS complement(55133..55615) FT /transl_table=11 FT /gene="Mb3197c" FT /locus_tag="Mb3197c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3197c, -, len: 160 aa. Equivalent to Rv3172c, len: FT 160 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 160 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TX40" FT /protein_id="CAD95289.1" FT /translation="MSVALLREMFDRMVVAKNAELIEHYYDPDFLMYSDGLSQSFAKFR FT DSHRKLYATAISYAVEYDEHAWVEAQTRLPGGCGSPRRDLARSRPASRWYSLPPTATAE FT FTGSGRRRGRVGATWPPSTITETTTDRLAMRNQLRAGAATLLFCDPMLQRFPATRK" FT CDS complement(55694..56296) FT /transl_table=11 FT /gene="Mb3198c" FT /locus_tag="Mb3198c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR/ACRR-FAMILY)" FT /note="Mb3198c, -, len: 200 aa. Equivalent to Rv3173c, len: FT 200 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 200 aa overlap). Probable FT transcriptional regulatory protein tetR family, similar to FT several bacterial putative regulatory proteins e.g. FT Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195 aa), FT FASTA scores: opt: 319, E(): 1.7e-13, (34.55% identity in FT 195 aa overlap); O85695|3SCF60.04 from Streptomyces FT lividans and Streptomyces coelicolor (192 aa), FASTA FT scores: opt: 297, E(): 4.3e-12, (37.45% identity in 187 aa FT overlap); BAB50853|MLR4117 from Rhizobium loti FT (Mesorhizobium loti) (205 aa), FASTA scores: opt: 280, E(): FT 5.5e-11, (31.45% identity in 194 aa overlap); FT BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti) FT (194 aa), FASTA scores: opt: 270, E(): 2.3e-10, (34.05% FT identity in 185 aa overlap); etc. Also similar to other FT regulators from Mycobacterium tuberculosis e.g. FT P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt: FT 154, E(): 0.0013, (38.8% identity in 80 aa overlap). FT Contains probable helix-turn-helix motif from aa 39 to 60 FT (Score 1251, +3.45 SD). SIMILAR TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7TX39" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7TX39" FT /protein_id="CAD95290.1" FT /translation="MPPVTRTTEPPRRGGRGARQRILKAAAELFYCEGINATGVELIAN FT KASVSKRTLYQHFPSKSALVEEYLRGLRQAAGEADKMPKASNATPRERLLALFDRPNRG FT DGRMRGCPFHNAAVEAAGEMPGVERIVHSHKRDYIKGLARLAREAGAAHPRSLGNQLAV FT LFEGAAALSTSLDDAGPWAHARAAAEVLIDQATARPV" FT CDS 56389..57096 FT /transl_table=11 FT /gene="Mb3199" FT /locus_tag="Mb3199" FT /product="PROBABLE SHORT-CHAIN DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3199, -, len: 235 aa. Equivalent to Rv3174, len: FT 235 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 235 aa overlap). Probable oxidoreductase FT short-chain dehyrogenase/reductase (EC 1.-.-.-), similar to FT others e.g. Q9RPT7|SITS from Streptomyces albus (223 aa), FT FASTA scores: opt: 654, E(): 6.1e-32, (49.3% identity in FT 215 aa overlap); Q9RI61|SCJ11.46 from Streptomyces FT coelicolor (230 aa), FASTA scores: opt: 626, E(): 2.9e-30, FT (50.9% identity in 224 aa overlap); Q9A5Z1|CC2306 from FT Caulobacter crescentus (252 aa), FASTA scores: opt: 430, FT E(): 1.3e-18, (39.45% identity in 228 aa overlap); Q51641 FT INSECT-TYPE DEHYDROGENASE (249 aa), FASTA scores: opt: 301, FT E(): 5.7e-11, (38.3% identity in 188 aa overlap); FT Q9HXC9|PA3883 from Pseudomonas aeruginosa (276 aa), FASTA FT scores: opt: 296, E(): 1.2e-10, (29.55% identity in 247 aa FT overlap); etc. MAY BE BELONG TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7TX38" FT /db_xref="HSSP:1FDU" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TX38" FT /protein_id="CAD95291.1" FT /translation="MTSLAERTALVTGANRGMGREYVAQLLGRKVAKVYAATRNPLAID FT VSDPRVIPLQLDVTDAVSVAEAADLATDVGILINNAGISRASSVLDKDTSALRGELETN FT LFGPLALASAFADRIAERSGAIVNVSSVLAWLPLGMSYGVSKAAMWSATESMRIELAPR FT GVQVVGVYVGLVDTDMGRFADAPKSDPADVVRQVLDGIEAGKEDVLADEMSRQVRASLN FT VPARERIARLMGN" FT CDS 57111..58598 FT /transl_table=11 FT /gene="Mb3200" FT /locus_tag="Mb3200" FT /product="POSSIBLE AMIDASE (AMINOHYDROLASE)" FT /EC_number="3.5.1.-" FT /note="Mb3200, -, len: 495 aa. Equivalent to Rv3175, len: FT 495 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 495 aa overlap). Possible amidase (EC FT 3.5.1.-), similar to others e.g. Q9F6D0|ZHUL ENANTIOMER FT SELECTIVE AMIDASE from Streptomyces sp. R1128 (507 aa), FT FASTA scores: opt: 1328 ,E(): 7.5e-69, (44.5% identity in FT 492 aa overlap); BAB51815|MLR5350 PROBABLE AMIDASE from FT Rhizobium loti (Mesorhizobium loti) (457 aa), FASTA scores: FT opt: 7487, E(): 1.3e-35, (35.9% identity in 482 aa FT overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE (EC FT 3.5.1.4) from Archaeoglobus fulgidus (453 aa), FASTA FT scores: opt: 532, E(): 3.2e-23, (32.05% identity in 471 aa FT overlap); etc. But also similar to glutamyl-tRNA FT amidotransferases who belong to amidase family e.g. FT Q9RTA9|DR1856 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE, SUBUNIT FT A from Deinococcus radiodurans (482 aa), FASTA scores: opt: FT 560, E(): 8.2e-25, (30.6% identity in 513 aa overlap); FT Q9LCX3|GATA GLU/ASP-TRNA AMIDOTRANSFERASE SUBUNIT A from FT Thermus aquaticus (subsp. thermophilus) (471 aa), FASTA FT scores: opt: 558, E(): 1.1e-24, (30.85% identity in 486 aa FT overlap); Q49091|GATA_MORCA GLUTAMYL-TRNA(GLN) FT AMIDOTRANSFERASE SUBUNIT A (EC 6.3.5.-) from Moraxella FT catarrhalis (492 aa), FASTA scores: opt: 526, E(): 7.5e-23, FT (30.45% identity in 473 aa overlap); etc. SEEMS TO BELONG FT TO THE AMIDASE FAMILY. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop)." FT /db_xref="GOA:Q7TX37" FT /db_xref="InterPro:IPR000120" FT /db_xref="UniProtKB/TrEMBL:Q7TX37" FT /protein_id="CAD95292.1" FT /translation="MAMSAKASDDIAWLPATAQLAVLAAKKVSSAELVELYLSRIDTYN FT ASLNAIVTVDPDAARRVAKRSDAARARGDELGPLHGLPITVKDSYETAGMRTTCGRRDL FT ADYVPTQDAEAVARLRRAGAIIMGKTNMPTGNQDVQASNPVFGRTNNPWDAARTSGGSA FT GGGAAATAAGLTSFDYGSEIGGSTRIPAHYCGLYGHKSTWRSVPLVGHIPSAPGNPGRW FT GQADMACAGVQVRGARDIIPALEATVGPMRADGGFSYALAPPRAGALKDFRVAVWAEDP FT HCPIDADVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFAVDRSTL FT SPASAAALGLRAVRHPRGEAANALGATLQSHRAWLFADAARHEMRDRWAGFFNEFDVLL FT LPVTPTPAPLHHNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATTMPITTTAT FT GLPIGIQAMGPAGGDRTTVEFAALLTEVLGGFRVPPL" FT CDS complement(58595..58912) FT /transl_table=11 FT /gene="mesTb" FT /locus_tag="Mb3201c" FT /standard_name="lipS" FT /product="PROBABLE EPOXIDE HYDROLASE MESTB [SECOND PART] FT (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)" FT /EC_number="3.3.2.3" FT /note="Mb3201c, mesTb, len: 105 aa. Equivalent to 3' end of FT Rv3176c, len: 318 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.000% identity in 105 aa overlap). FT Probable mesT,epoxide hydrolase (EC3.3.2.3), similar to FT others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN FT (MESODERM SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO FT ALPHA/BETA HYDROLASE FOLD) from Homo sapiens (Human) (335 FT aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity FT in 280 aa overlap); AAH06639|Q07646 MEST PROTEIN from Mus FT musculus (Mouse) (335 aa), FASTA scores: opt: 342, E(): FT 1.4e-14, (31.45% identity in 280 aa overlap); Q9I8E7|MEST FT EPOXIDE HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese FT pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: FT opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa FT overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from FT Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa), FASTA FT scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa FT overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from FT Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, FT E(): 3e-09, (29.85% identity in 288 aa overlap); FT O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium FT radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, FT (27.0% identity in 278 aa overlap); etc. Also similar to FT Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA FT PROTEIN from Mycobacterium tuberculosis (288 aa), FASTA FT scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa FT overlap). Equivalent to AAK47604 from Mycobacterium FT tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. FT SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO FT PEPTIDASE FAMILY S33. Note that previously known as lipS. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, mesT exists as a single gene. In FT Mycobacterium bovis, a frameshift due to a single base FT deletion (c-*) splits mesT into 2 parts, mesTa and mesTb." FT /db_xref="GOA:Q7TX36" FT /db_xref="UniProtKB/TrEMBL:Q7TX36" FT /protein_id="CAD95293.1" FT /translation="MKELHDAISRRDGVRVLPATAGFVDEHREHAARWDLARIISALGD FT EVAFGVVGSAEDPFEGEQLRLARERLADSVEITELAGGHLTTAEQPDRLAEVIAALPER FT S" FT CDS complement(58924..59550) FT /transl_table=11 FT /gene="mesTa" FT /locus_tag="Mb3202c" FT /standard_name="lipS" FT /product="PROBABLE EPOXIDE HYDROLASE MESTA [FIRST PART] FT (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)" FT /EC_number="3.3.2.3" FT /note="Mb3202c, mesTa, len: 208 aa. Equivalent to 5' end of FT Rv3176c, len: 318 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 201 aa overlap). Probable FT mesT, epoxide hydrolase (EC 3.3.2.3), similar to others FT e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM FT SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA FT HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA FT scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa FT overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus FT (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14, FT (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE FT HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese FT pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: FT opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa FT overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from FT Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa), FASTA FT scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa FT overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from FT Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, FT E(): 3e-09, (29.85% identity in 288 aa overlap); FT O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium FT radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, FT (27.0% identity in 278 aa overlap); etc. Also similar to FT Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA FT PROTEIN from Mycobacterium tuberculosis (288 aa), FASTA FT scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa FT overlap). Equivalent to AAK47604 from Mycobacterium FT tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. FT SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO FT PEPTIDASE FAMILY S33. Note that previously known as lipS. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, mesT exists as a single gene. In FT Mycobacterium bovis, a frameshift due to a single base FT deletion (c-*) splits mesT into 2 parts, mesTa and mesTb." FT /db_xref="GOA:Q7TX35" FT /db_xref="HSSP:1EHY" FT /db_xref="UniProtKB/TrEMBL:Q7TX35" FT /protein_id="CAD95294.1" FT /translation="MTHRASALISAQEWFSAGERVGYDAERPGINPRSPLRAFIRRAAG FT TGVTRTFLPGWPDGSYGWAKVEAFLSSRFHFPRIYLDYIGHGDSDKPRDYPYSTFERAD FT LVEALWHAEGIAQTVVVAFDYSCIVSLELLARRIDRERAGNDQRTRITACLLANGGIFA FT DGHTHAWYTTPLLTSPLGAAITPIGQRSWRMFAPFLRPSSRADTH" FT CDS 59697..60557 FT /transl_table=11 FT /gene="Mb3203" FT /locus_tag="Mb3203" FT /product="POSSIBLE PEROXIDASE (NON-HAEM PEROXIDASE)" FT /EC_number="1.11.1.-" FT /note="Mb3203, -, len: 286 aa. Equivalent to Rv3177, len: FT 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 286 aa overlap). Possible peroxidase FT (non-haem peroxidase) (EC 1.11.1.-), highly similar to FT Q9KJF9|W78 CULTIVAR SPECIFICITY PROTEIN (SIMILAR TO FT ALPHA/BETA HYDROLASE FOLD) W78 from Rhizobium leguminosarum FT (287 aa), FASTA scores: opt: 1059, E(): 2.3e-59, (61.4% FT identity in 272 aa overlap); BAB48728|MLL1328 HYPOTHETICAL FT PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FT FASTA scores: opt: 746, E(): 1.1e-39, (43.25% identity in FT 282 aa overlap). Similar to nonheme chloroperoxidases and FT related esterases e.g. O73957|SAL LIPOLYTIC ENZYME from FT Sulfolobus acidocaldarius (314 aa), FASTA scores: opt: 408, FT E(): 1.9e-18, (32.4% identity in 287 aa overlap); FT Q9AJM9|BIOH PROTEIN INVOLVED IN BIOTIN SYNTHESIS from FT Kurthia sp. 538-KA26 (267 aa), FASTA scores: opt: 324 ,E(): FT 3.2e-13, (30.0% identity in 250 aa overlap); Q9CBB1|ML2269 FT PUTATIVE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) FT from Mycobacterium leprae (265 aa); O05691|THCF_RHOER FT NON-HEME HALOPEROXIDASE (EC 1.11.1.-) from Rhodococcus FT erythropolis (SIMILAR TO OTHER BACTERIAL NON-HEME BROMO- FT AND CHLORO-PEROXIDASES) (274 aa), FASTA scores: opt: 279, FT E(): 2.2e-10, (29.0% identity in 276 aa overlap); FT Q53540|EST ESTERASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) FT from Pseudomonas putida (276 aa), FASTA scores: opt: 271, FT E(): 7.1e-10, (29.65% identity in 280 aa overlap); etc. FT Also similar to O06420|BPOC|Rv0554|MTCY25D10.33 FT HYPOTHETICAL 28.3 KDA PROTEIN (SIMILAR TO ALPHA/BETA FT HYDROLASE FOLD) from M. tuberculosis (262 aa), FASTA FT scores: opt: 280 ,E(): 1.8e-10, (28.0% identity in 257 aa FT overlap). Equivalent to AAK47605 from Mycobacterium FT tuberculosis strain CDC1551 (300 aa) but shorter 14 aa. FT SIMILAR TO ALPHA/BETA HYDROLASE FOLD." FT /db_xref="GOA:Q7TX34" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7TX34" FT /protein_id="CAD95295.1" FT /translation="MPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLGADAGVPVIFLH FT HLGAVLDNWDPRVVDGIAAKHPVVTFDNRGVGASEGQTPDTVTTMADDAIAFVRALGFD FT QVDLLGFSLGGFVAQVIAQQEPQLVRKIILAGTGPAGGVGIGKVTFGTIRESIKATLTF FT RDPKELRFFTRTDSGKSAARQFVKRLKERKDNRDKSITVRAFRSQLKAIHAWGTQKPSD FT LTSIGHPVLIANGDDDTMVPTSNSLDLADRLPDATLRIYPDAGHGGIFQHHAQFVDDAL FT QFLES" FT CDS 60688..61047 FT /transl_table=11 FT /gene="Mb3204" FT /locus_tag="Mb3204" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3204, -, len: 119 aa. Equivalent to Rv3178, len: FT 119 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 119 aa overlap). Hypothetical protein, FT with some similarity to other hypothetical bacterial FT proteins (principaly mycobacterium and streptomyces FT proteins) e.g. P71854|Rv3547|MTCY03C7.09c from M. FT tuberculosis strain H37Rv (151 aa), FASTA scores: opt: 310, FT E(): 2e-14, (40.5% identity in 116 aa overlap); Q9ZH81 from FT M. paratuberculosis (144 aa), FASTA scores: opt: 274, E(): FT 5.6e-12, (38.9% identity in 108 aa overlap); FT O85698|3SCF60.07 from Streptomyces lividans and FT Streptomyces coelicolor (149 aa), FASTA scores: opt: 235, FT E(): 2.7e-09, (35.2% identity in 108 aa overlap); FT Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c (148 aa); FT Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa); etc. FT Equivalent to AAK47606 from Mycobacterium tuberculosis FT strain CDC1551 (171 aa) but shorter 52 aa." FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/TrEMBL:Q7TX33" FT /protein_id="CAD95296.1" FT /translation="MRLGAGFRKPVPTLLLEHRSRKSGKNFVAPLLYITDRNNVIVVAS FT ALGQAENPQWYRNLPPNPDTHIQIGSDRRPVRAVVASSDERARLWPRPVDAYADFDSCQ FT SWTERGIPVIILRPR" FT CDS 61868..63157 FT /transl_table=11 FT /gene="Mb3205" FT /locus_tag="Mb3205" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3205, -, len: 429 aa. Equivalent to Rv3179, len: FT 429 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 429 aa overlap). Conserved hypothetical FT protein, highly similar to Q9KH61 PUTATIVE ATP/GTP BINDING FT PROTEIN from Mycobacterium smegmatis (428 aa), FASTA FT scores: opt: 2466, E(): 1.5e-148, (89.7% identity in 428 aa FT overlap) (no article found on the NCBI web site (July FT 2001)); and to other hypothetical bacterial proteins e.g. FT O07781|Rv0597c|MTCY19H5.25 from M. tuberculosis (411 aa), FT FASTA scores: opt: 1031, E(): 8e-58, (41.5% identity in 417 FT aa overlap); BAB54715|MLR9349 from Rhizobium loti FT (Mesorhizobium loti) (435 aa), FASTA scores: opt: 365, E(): FT 1.1e-15, (31.75% identity in 416 aa overlap); etc. FT Equivalent to AAK47609 from Mycobacterium tuberculosis FT strain CDC1551 (454 aa) but shorter 25 aa. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="UniProtKB/TrEMBL:Q7TX32" FT /protein_id="CAD95297.1" FT /translation="MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQQ FT LHAELGGWLRSLDVDVERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATDRD FT RRPRQFFLSGSTRFLTVPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEPQVV FT LGTEPAPVTRHEYLQLACAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKRIEQT FT DRLPRFMRYLAAITAQELNVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWSRNLTA FT KIKKRSKIHVVDSGFAAWLRGQSADSLARPTAEGAGPIMETFVINELMKLRAATELEVD FT LYHFRDRDGREIDCILQTPDSRVVGVEVKASATVNVHDFRHLSFARDRLGDEFITGVLF FT YTGARALPFGDRLMALPINLLWNGQSVSSL" FT CDS complement(63504..63938) FT /transl_table=11 FT /gene="Mb3206c" FT /locus_tag="Mb3206c" FT /product="HYPOTHETICAL ALANINE RICH PROTEIN" FT /note="Mb3206c, -, len: 144 aa. Equivalent to Rv3180c, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 144 aa overlap). Hypothetical unknown FT ala-rich protein. Contains probable coiled-coil domain from FT aa 40 to 70." FT /db_xref="UniProtKB/TrEMBL:Q7TX31" FT /protein_id="CAD95298.1" FT /translation="MPLVYFDASAFVKLLTTETGSSLASALWDGCDAALSSRLAYPEVR FT AALAAAARNHDLTESELADAERDWEDFWAATRPVELTATVEQHAGHLARAHALRGADAV FT HLASALAVGDPGLVVAVWDRRLHTGAHAAGCRVAPAQLDP" FT CDS complement(63941..64393) FT /transl_table=11 FT /gene="Mb3207c" FT /locus_tag="Mb3207c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3207c, -, len: 150 aa. Equivalent to Rv3181c, len: FT 150 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 150 aa overlap). Hypothetical protein, FT with some similarity to other mycobacterium proteins e.g. FT Q50718|YY07_MYCTU|Rv3407|MT3515|MTCY78.21c (99 aa), FASTA FT scores: opt: 123, E(): 0.25, (33.7% identity in 89 aa FT overlap); and O50412|Rv3385c|MTV004.43c (102 aa), FASTA FT scores: opt: 123, E(): 0.26, (39.7% identity in 68 aa FT overlap)." FT /db_xref="InterPro:IPR006442" FT /db_xref="UniProtKB/TrEMBL:Q7TX30" FT /protein_id="CAD95299.1" FT /translation="MQLGRKVTSHHDIDRFGVASTADESVYRPLPPRLRLAQVNLSRRR FT CRTQSDMYKSRFSECTVQSVDVSVTELRAHLSDWLDRARAGGEVVITERGIPIARLAAL FT DSTDTLERLTAEGVIGKATAQRPVAAGRPRPRPQRPVSDRVSDQRR" FT CDS 64624..64968 FT /transl_table=11 FT /gene="Mb3208" FT /locus_tag="Mb3208" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3208, -, len: 114 aa. Equivalent to Rv3182, len: FT 114 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 114 aa overlap). Hypothetical protein, FT with some similarity to other hypothetical bacterial FT proteins e.g. O53468|Rv2022c|MTV018.09c from M. FT tuberculosis (201 aa), FASTA scores: opt: 335, E(): FT 3.6e-16, (51.9% identity in 104 aa overlap); and FT Q9L3R6|ORF119 from Anabaena sp. strain PCC 7120 (119 aa), FT FASTA scores: opt: 250, E(): 1.6e-10, (42.1% identity in 95 FT aa overlap). Equivalent to AAK47614 from Mycobacterium FT tuberculosis strain CDC1551 (94 aa) but longer 20 aa." FT /db_xref="InterPro:IPR018670" FT /db_xref="UniProtKB/TrEMBL:Q7TX29" FT /protein_id="CAD95300.1" FT /translation="MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDK FT VNDSTFHNMKELRPAGTSIRILFAFDPARQAILLLGGDKAGNWKRWYDNNIPIADQRSE FT NWLASEHGGG" FT CDS 64965..65294 FT /transl_table=11 FT /gene="Mb3209" FT /locus_tag="Mb3209" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb3209, -, len: 109 aa. Equivalent to Rv3183, len: FT 109 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 109 aa overlap). Possible FT transcriptional regulator, similar to others e.g. FT Q9S1D9|YPPCP1.08c from Yersinia pestis (99 aa), FASTA FT scores: opt: 119, E(): 0.47, (40.55% identity in 74 aa FT overlap); Q9X153|TM1330 from Thermotoga maritima (111 aa), FT FASTA scores: opt: 115, E(): 0.91, (40.35% identity in 57 FT aa overlap); P95258|Rv1956|MTCY09F9.08c (alias AAK46277 FT putative DNA-binding protein from strain CDC1551) (149 aa), FT FASTA scores: opt: 116, E(): 1, (42.25% identity in 71 aa FT overlap). Also similar to O53467|Rv2021c|MTV018.08c from FT Mycobacterium tuberculosis (101 aa), FASTA scores: opt: FT 214, E(): 5.8e-07, (43.0% identity in 107 aa overlap). FT Contains probable helix-turn-helix motif from aa 51 to 72 FT (Score 1803, +5.33 SD)." FT /db_xref="GOA:Q7TX28" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/TrEMBL:Q7TX28" FT /protein_id="CAD95301.1" FT /translation="MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIR FT KALGHARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIVAEFGENT FT VELTA" FT CDS 65832..66179 FT /transl_table=11 FT /gene="Mb3210" FT /locus_tag="Mb3210" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3210, -, len: 115 aa. Equivalent to Rv3188, len: FT 115 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 115 aa overlap). Conserved hypothetical FT protein, with similarity to other proteins from FT Mycobacterium tuberculosis: FT Q10868|YJ90_MYCTU|Rv1990c|MT2044|MTCY39.29 HYPOTHETICAL FT PROTEIN (113 aa), FASTA scores: opt: 184, E(): 8.1e-06, FT (28.45% identity in 109 aa overlap); and FT O06299|Rv0348|MTCY13E10.08 HYPOTHETICAL PROTEIN (217 aa), FT FASTA scores: opt: 129, E(): 0.074, (30.0% identity in 100 FT aa overlap). Also some similarity with C-terminus of FT Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 FT aa), FASTA scores: opt: 114, E(): 0.76, (30.0% identity in FT 110 aa overlap) (for this one, no similarity exists in the FT N-terminal region with the N-terminus of other regulatory FT components of sensory transduction systems)." FT /db_xref="UniProtKB/TrEMBL:Q7TX27" FT /protein_id="CAD95302.1" FT /translation="MAVTLDRAVEASEIVDALKPFGVTQVDVAAVIQVSDRAVRGWRTG FT DIRPERYDRLAQLRDLVLLLSDSLTPRGVGQWLHAKNRLLDGQRPVDLLAKDRYEDVRS FT AAESFIDGAYV" FT CDS 66176..66796 FT /transl_table=11 FT /gene="Mb3211" FT /locus_tag="Mb3211" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3211, -, len: 206 aa. Equivalent to Rv3189, len: FT 206 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 206 aa overlap). Conserved hypothetical FT protein, weakly similar to other proteins from FT Mycobacterium tuberculosis e.g. FT O86329|MBTE|Rv2380c|MTCY22H8.05 (1682 aa), FASTA scores: FT opt: 135, E(): 0.79, (27.8% identity in 187 aa overlap); FT and Q10869|YJ89_MYCTU|Rv1989c|MT2043MTCY39.30 (186 aa), FT FASTA scores: opt: 122, E(): 0.85, (32.25% identity in 93 FT aa overlap)." FT /db_xref="InterPro:IPR014914" FT /db_xref="UniProtKB/TrEMBL:Q7TX26" FT /protein_id="CAD95303.1" FT /translation="MKLADAIATAPRRTLKGTYWHQGPTRHPVTSCADPARGPGRYHRT FT GEPGVWYASNKEQGAWAELFRHFVDDGVDPFEVRRRVGRVAVTLQVLDLTDERTRSHLG FT VDETDLLSDDYTTTQAIAAARDANFDAVLAPAAALPGCQTLAVFVHALPNIEPERSEVR FT QPPPRLANLLPLIRPHEHMPDSVRRLLATLTRAGAEAIRRRRR" FT CDS complement(66956..68221) FT /transl_table=11 FT /gene="Mb3212c" FT /locus_tag="Mb3212c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3212c, -, len: 421 aa. Equivalent to Rv3190c, len: FT 421 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 421 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TX25" FT /protein_id="CAD95304.1" FT /translation="MEYVQLFSKGRLNDLAGSLAGFLGKASQATAQRLQSWDADDLLNT FT PVDDVVEQLVELGSVECPDLRVDDAFMLPATEVDQQYRDWGEQRTRRVTRLVLVVPFEG FT HKDIFNLRPDQFTTMPPQVLRLQGHEIHLAIDNPSNDAAAINAAFHKQIANIEKYLGWS FT RRQIDLHNQGLRNELPGMVARRREQLLATRNLQAEIGFPVRRRKDADTYAAPISRKSVR FT PRPHRPAGARAAFKPEPAMQDEDYQSALRVLRNQRNALERTPSVAAKLDGEEIRDMLLV FT GLNAQFEGDAGGELFNGAGKTDILIRVDDRNIFIGECKVWSGPRTMDDALKQLFGYLVW FT RDTKAAILLFIRNKDVTAVIDNAIAKIKEHPNHKRCPAHRAGADQYEFTMHADGDPERE FT IHLTLIPFALRPTAEVPTTTIP" FT repeat_region 68796..68858 FT /rpt_type=INVERTED FT /note="63 bp imperfect inverted repeat, IRR, FT TGTCAGCGGCAACCGAAAACTGATCAGGTGTCGGCAAGGTGGTTTCTAGGCGGTGTCGC FT AACA, flanking IS element IS1603." FT repeat_region complement(68796..70185) FT /mobile_element="insertion sequence:IS1603" FT /locus_tag="IS1603" FT /note="IS1603, len: 1390 nt. Equivalent to IS1603, len: FT 1032 nt, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 1032 nt overlap)." FT CDS complement(68845..69879) FT /transl_table=11 FT /gene="Mb3213c" FT /locus_tag="Mb3213c" FT /product="PROBABLE TRANSPOSASE" FT /note="Mb3213c, -, len: 344 aa. Equivalent to Rv3191c, len: FT 344 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 344 aa overlap). Probable transposase, FT similar to many especially Q9K2N8 PUTATIVE TRANSPOSASE from FT Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 837, FT E(): 1.3e-43, (42.55% identity in 336 aa overlap); Q9RBF4 FT INSERTION SEQUENCE IS1088 from Alcaligenes eutrophus FT (Ralstonia eutropha) (342 aa), FASTA scores: opt: 823, E(): FT 9.2e-43, (43.05% identity in 337 aa overlap); and Q51379 FT PUTATIVE TRANSPOSASE from Pseudomonas alcaligenes (338 aa), FT FASTA scores: opt: 818, E(): 1.8e-42, (42.35% identity in FT 333 aa overlap). Contains probable helix-turn-helix motif FT from aa 25 to 46 (Score 1968, +5.89 SD)." FT /db_xref="GOA:Q7TX24" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/TrEMBL:Q7TX24" FT /protein_id="CAD95305.1" FT /translation="MRQISSRYLSEEERINIADLRRSGLSIRKIADQLGRAPSTVSREL FT RRNSRRDGQYRPFEAHRWAVQRRVRRHRRRIDKNPDLCELIAELLAQRWSPQQIARHLR FT RKYPDDRSMWLCHESIYQAVYQPQSRLIRPPQVKSPHRGPLRTGRTHRRAHLRPGRRRP FT RFAQPMLSIHQRPFDPADRSEPGHWEGDLIVGKNQGSAIGTLVERQTRLIRLLHLPTHD FT AYCLRIAITETMSDLPVTLVRSITWDQGIEMARHIDITADLGAPVYFCDSRSPWQRASN FT ENSNGLLRQYFPKGTSLSTYTPDHLRAVEYEINNRPRQVLGHRSPAELFTALLTSPDHQ FT LLRR" FT repeat_region complement(70123..70185) FT /rpt_type=INVERTED FT /note="63 bp imperfect inverted repeat, IRL, FT TGTCGGCGGCAACTGAATACTGACCAGAGCGCGGCAAGGTGGGTTCTAGTCAACGTCGC FT AACA, flanking IS element IS1603." FT tRNA complement(70905..70978) FT /gene="metU" FT /locus_tag="metU" FT /note="metU, len: 74 nt. Equivalent to metU, len: 74 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 74 nt overlap). tRNA-f-Met, anticodon cat. FT Described in EM_BA: MTMETA Y08623 M.tuberculosis as metA FT gene. Name changed to metU as metA encodes homoserine FT transsuccinylase." FT CDS 71098..71559 FT /transl_table=11 FT /gene="Mb3214" FT /locus_tag="Mb3214" FT /product="CONSERVED HYPOTHETICAL ALANINE AND PROLINE-RICH FT PROTEIN" FT /note="Mb3214, -, len: 153 aa. Equivalent to Rv3192, len: FT 153 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 153 aa overlap). Conserved hypothetical FT ala- and pro-rich protein, with weak similarity to FT N-terminal half of several proteins e.g. FT Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL FT 37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa), FT FASTA scores: opt: 245, E(): 3.7e-08, (33.1% identity in FT 157 aa overlap); O30260|AF2411 CONSERVED HYPOTHETICAL FT PROTEIN from Archaeoglobus fulgidus (363 aa), FASTA scores: FT opt: 144, E(): 0.072, (32.6% identity in 92 aa overlap); FT Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from FT Streptomyces violaceoruber (343 aa), FASTA scores: opt: FT 133, E(): 0.33, (25.15% identity in 159 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TX23" FT /protein_id="CAD95306.1" FT /translation="MIPQPLSQLGDLARRPGRRVLCSPKTAAPSISNATVASPAAPGLE FT LSTGIALAFPRGPFVPAAAAWELQEATSGKFQLGLGTQVRKNVVHRYGMAFHRPGPRLR FT YLLAVKACFAVFQTGTPDHHGEFDNPDFITAQWSPARIDPPGPSPAGPR" FT CDS complement(71729..74707) FT /transl_table=11 FT /gene="Mb3215c" FT /locus_tag="Mb3215c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb3215c, -, len: 992 aa. Equivalent to Rv3193c, len: FT 992 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 992 aa overlap). Probable conserved FT transmembrane protein, with hydrophobic N-terminal domain FT (~1-340 aa), highly similar to Q9CCM6|ML0644 PUTATIVE FT INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (983 FT aa), FASTA scores: opt: 5421, E(): 0, (86.15% identity in FT 989 aa overlap); and O53609|Rv0064|MTV030.07 PUTATIVE FT MEMBRANE PROTEIN from Mycobacterium tuberculosis strain FT H37Rv (979 aa), FASTA scores: opt: 3204, E(): 2.1e-142, FT (50.25% identity in 985 aa overlap). C-terminal part FT (709-990 aa) highly similar to O32904|MLCB1779.46 FT HYPOTHETICAL 29.1 KDA PROTEIN from Mycobacterium leprae FT (277 aa), FASTA scores: opt: 1521, E(): 3.4e-64, (82.6% FT identity in 282 aa overlap). Also some similarity to FT hypothetical proteins generally transmembrane e.g. FT Q9FCI4|2SC3B6.28 from Streptomyces coelicolor (815 aa), FT FASTA scores: opt: 951, E(): 3.4e-37, (39.2% identity in FT 826 aa overlap); P72637|SLL1060 from Synechocystis sp. FT strain PCC 6803 (1032 aa), FASTA scores: opt: 938, E(): FT 1.6e-36, (29.95% identity in 855 aa overlap); O28851|AF1421 FT from Archaeoglobus fulgidus (880 aa), FASTA scores: opt: FT 526, E(): 2.6e-17, (28.05% identity in 970 aa overlap); FT etc." FT /db_xref="GOA:Q7TX22" FT /db_xref="InterPro:IPR005372" FT /db_xref="UniProtKB/Swiss-Prot:Q7TX22" FT /protein_id="CAD95307.1" FT /translation="MGMRSAARMPKLTRRSRILIMIALGVIVLLLAGPRLIDAYVDWLW FT FGELGYRSVFTTMLATRIVVCLVAGVVVGGIVFGGLALAYRTRPVFVPDADNDPVARYR FT AVVLARLRLVGIGIPAAIGLLAGIVAQSYWARIQLFLHGGDFGVRDPQFGRDLGFYAFE FT LPFYRLMLSYMLVSVFLAFVANLVAHYIFGGIRLSGRTGALSRSARVQLVSLVGVLVLL FT KAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAAAVFSAIALRD FT LRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSITATRQAYGLTSD FT VVTYRNYSGDSPATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFPDQLSID FT RYLDRNGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGFIASPANTVRGIANDP FT NQNGGYPEFLVNVVGANGTVVSDGPAPLDQPRIYFGPVISNTSADYAIVGRNGDDREYD FT YETNIDTKRYTYTGSGGVPLGGWLARSVFAAKFAERNFLFSNVIGSNSKILFNRDPAQR FT VEAVAPWLTTDSAVYPAIVNKRLVWIVDGYTTLDNYPYSELTSLSSATADSNEVAFNRL FT VPDKKVSYIRNSVKATVDAYDGTVTLYQQDEKDPVLKAWMQVFPGTVKPKSDIAPELAE FT HLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASSYQPPYYIVAKNIA FT KDDNSASYQLISAMNRFKRDYLAAYISASSDPATYGNLTVLTIPGQVNGPKLANNAITT FT DPAVSQDLGVIGRDNQNRIRWGNLLTLPVAQGGLLYVEPVYASPGASDAASSYPRLIRV FT AMMYNDKVGYGPTVRDALTGLFGPGAGATATGIAPTEAAVPPSPAANPPPPASGPQPPP FT VTAAPPVPVGAVTLSPAKVAALQEIQAAIGAARDAQKKGDFAAYGSALQRLDEAITKFN FT DAG" FT CDS complement(74799..75821) FT /transl_table=11 FT /gene="Mb3216c" FT /locus_tag="Mb3216c" FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT /note="Mb3216c, -, len: 340 aa. Equivalent to Rv3194c, len: FT 340 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 340 aa overlap). Possible conserved FT secreted protein (N-terminal stretch hydrophobic), FT equivalent to Q9CCM7|ML0643 PUTATIVE SECRETED PROTEIN from FT Mycobacterium leprae (340 aa), FASTA scores: opt: 1822, FT E(): 1.6e-102, (80.3% identity in 340 aa overlap). Also FT similar to other proteins e.g. Q9FCI6|2SC3B6.26 PUTATIVE FT SECRETED PROTEIN from Streptomyces coelicolor (364 aa), FT FASTA scores: opt: 430, E(): 1.1e-18, (40.95% identity in FT 359 aa overlap); Q9S3Y5|SDRC SDRC PROTEIN from Streptomyces FT coelicolor (241 aa), FASTA scores: opt: 396, E(): 8.9e-17, FT (35.2% identity in 318 aa overlap) (similarity in part for FT this one); O34470|YLBL YLBL PROTEIN from Bacillus subtilis FT (350 aa), FASTA scores: opt: 385, E(): 5.6e-16, (27.7% FT identity in 350 aa overlap); etc." FT /db_xref="GOA:Q7TX21" FT /db_xref="InterPro:IPR001478" FT /db_xref="UniProtKB/TrEMBL:Q7TX21" FT /protein_id="CAD95308.1" FT /translation="MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEID FT GKQVVQIVGTQTYPTSGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGKSR FT EEIENDNAADFKRSEAAAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGT FT PVGNLDQFTALLKNTKPGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPW FT APFAVDFHLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGGIT FT HKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALHAMTSGSPTPSC FT " FT CDS 75899..77317 FT /transl_table=11 FT /gene="Mb3217" FT /locus_tag="Mb3217" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3217, -, len: 472 aa. Equivalent to Rv3195, len: FT 472 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 472 aa overlap). Hypothetical protein, FT equivalent to Q49746|ML0642|B1937_C3_231 HYPOTHETICAL 50.3 FT KDA PROTEIN from Mycobacterium leprae (479 aa), FASTA FT scores: opt: 2503, E(): 1e-138, (79.35% identity in 475 aa FT overlap). Similar in part to Q9FCI9|2SC3B6.23c CONSERVED FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (487 aa), FT FASTA scores: opt: 1382, E(): 2.7e-73, (46.4% identity in FT 489 aa overlap); Q9X8I7|SCE9.14 HYPOTHETICAL 41.2 KDA FT PROTEIN from Streptomyces coelicolor (375 aa), FASTA FT scores: opt: 319, E(): 2.4e-11, (25.6% identity in 383 aa FT overlap); etc." FT /db_xref="InterPro:IPR018766" FT /db_xref="UniProtKB/TrEMBL:Q7TX20" FT /protein_id="CAD95309.1" FT /translation="MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPLG FT AFGIGGEFNMADLGQIFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIAPI FT PAATNSAIADAVHLADTWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMAQQI FT STVWASSLPEEAKSMAGPLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLPLGPK FT GVAAILPGAVESFAAGLEQPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVEAYAMG FT MKIDMTGIEELARDINPTSLADPAAMEQLLSQGVFEPKATPAQTQALERLETLLALIEG FT WVQTVVTAALGERIPGEAALSETLRRRRASGGPAEQTFATLVGLELRPRKLREAGALWE FT RLTRAVGMDARDAVWQHPDLLPATDDLDDPAAFIDRVIGGDTSGIDEAIAELERDQQAR FT GADDSGHDGGPVDN" FT CDS 77323..78222 FT /transl_table=11 FT /gene="Mb3218" FT /locus_tag="Mb3218" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3218, -, len: 299 aa. Equivalent to Rv3196, len: FT 299 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 299 aa overlap). Hypothetical protein, FT with some similarity to other hypothetical proteins e.g. FT Q9FCJ5|2SC3B6.17c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (442 aa), FASTA scores: opt: 233, FT E(): 3.5e-07, (29.9% identity in 261 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TX19" FT /protein_id="CAD95310.1" FT /translation="MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRRA FT VLVRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGVAT FT PLANPGNLDSRRRAASIRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVDLVV FT LSDYLVADPHMVRDLHTERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSDRDAA FT WPAIAAQLRDTVGVADRATLLATAALALSQVNRVIAAVRGQEATPEPPSALNTTLEFDL FT NAGSIVARQWTRHPRCFC" FT CDS complement(78231..78431) FT /transl_table=11 FT /gene="Mb3219c" FT /locus_tag="Mb3219c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3219c, -, len: 66 aa. Equivalent to Rv3196A, len: FT 66 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 66 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TX18" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95311.1" FT /translation="MQEGGPQETMSARSTQHDAADALFRAIIETLDKHRNERTLTEDVL FT DTLARAYASISTNVPEQGRLG" FT CDS 78569..79912 FT /transl_table=11 FT /gene="Mb3220" FT /locus_tag="Mb3220" FT /product="PROBABLE CONSERVED ATP-BINDING PROTEIN ABC FT TRANSPORTER" FT /note="Mb3220, -, len: 447 aa. Equivalent to Rv3197, len: FT 447 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 447 aa overlap). Probable conserved FT ATP-binding protein ABC transporter, highly similar to FT Mycobacterium leprae proteins: Q9CCM8|ML0640 HYPOTHETICAL FT PROTEIN (473 aa), FASTA scores: opt: 2512, E(): 2.1e-140, FT (83.0% identity in 447 aa overlap). Interestingly, the FT N-terminal half (1-219 aa) corresponds to FT Q49747|ABC1|B1937_C3_233 ABC1 PROTEIN from Mycobacterium FT leprae (267 aa), FASTA scores: opt: 1276, E(): 6.3e-68, FT (88.6% identity in 219 aa overlap); and the C-terminal half FT (239-447 aa) corresponds to Q49745|B1937_C2_179 FT HYPOTHETICAL 23.1 KDA PROTEIN (206 aa), FASTA scores: opt: FT 1138, E(): 6.5e-60, (77.05% identity in 209 aa overlap); FT two adjacent orfs from Mycobacterium leprae. Also highly FT similar to other proteins (generally ABC transporters) e.g. FT Q9FCJ6|2SC3B6.16c HYPOTHETICAL 51.3 KDA PROTEIN from FT Streptomyces coelicolor (469 aa), FASTA scores: opt: 1340, FT E(): 1.8e-71, (45.9% identity in 449 aa overlap); FT O65576|ABC1AT ABC1 PROTEIN (alias FT Q9SBB2|T15B16.14|AT4G01660 PUTATIVE ABC TRANSPORTER) from FT Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA FT scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa FT overlap); O27682|MTH1645 ABC TRANSPORTER from FT Methanobacterium thermoautotrophicum (623 aa), FASTA FT scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa FT overlap); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FT FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7TX17" FT /db_xref="InterPro:IPR004147" FT /db_xref="UniProtKB/TrEMBL:Q7TX17" FT /protein_id="CAD95312.1" FT /translation="MDDGSVSDIKRGRAARNAKLASIPVGFAGRAALGLGKRLTGKSKD FT EVTAELMEKAANQLFTVLGELKGGAMKVGQALSVMEAAIPDEFGEPYREALTKLQKDAP FT PLPASKVHRVLDGQLGTKWRERFSSFNDTPVASASIGQVHKAIWSDGREVAVKIQYPGA FT DEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVERTEMELDYRLEAANQRAFAKAYH FT DHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDAPRRLG FT LMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPGGFPIELGMTIRLAREKNYDLLLPTMEK FT AGLIQRGRQVSVREIDEMLRQYVEPIQVEVFHYTRKWLQKMTVSQIDRSVAQIRTARQM FT DLPAKLAIPMRVIASVGAILCQLDAHVPIKALSEELIPGFAEPDAIVV" FT CDS complement(79946..80224) FT /transl_table=11 FT /gene="whiB7" FT /locus_tag="Mb3221c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT WHIB-LIKE WHIB7" FT /note="Mb3221c, whiB7, len: 92 aa. Equivalent to Rv3197A, FT len: 92 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 92 aa overlap). Probable whiB7, FT WhiB-like regulatory protein (see citation below), similar FT to WhiB paralogue of Streptomyces coelicolor, wblE gene FT product (85 aa). Equivalent to FT Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL FT REGULATOR WHIB7 from Mycobacterium leprae (89 aa), FASTA FT scores: opt: 441, E(): 6.3e-24, (69.3% identity in 88 aa FT overlap). Similar to Q9FCJ8|2SC3B6.14 PUTATIVE DNA-BINDING FT PROTEIN from Streptomyces coelicolor (122 aa), FASTA FT scores: opt: 348, E(): 2.2e-17, (57.7% identity in 78 aa FT overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from FT Streptomyces coelicolor (102 aa), FASTA scores: opt: 166, FT E(): 7.1e-05, (39.4% identity in 76 aa overlap); etc." FT /db_xref="GOA:Q7TX16" FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q7TX16" FT /protein_id="CAD95313.1" FT /translation="MSVLTVPRQTPRQRLPVLPCHVGDPDLWFADTPAGLEVAKTLCVS FT CPIRRQCLAAALQRAEPWGVWGGEIFDQGSIVSHKRPRGRPRKDAVA" FT CDS complement(80654..82756) FT /transl_table=11 FT /gene="uvrD2" FT /locus_tag="Mb3222c" FT /product="PROBABLE DNA HELICASE II HOMOLOG UVRD2" FT /EC_number="3.6.1.-" FT /note="Mb3222c, UvrD2, len: 700 aa. Equivalent to Rv3198c, FT len: 700 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 700 aa overlap). Probable UvrD2, DNA FT helicase II homolog (EC 3.6.1.-), equivalent to FT P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 PROBABLE DNA FT HELICASE II HOMOLOG from Mycobacterium leprae (714 aa), FT FASTA scores: opt: 3749, E(): 0, (82.85% identity in 706 aa FT overlap); and C-terminal half (466-700 aa) corresponds to FT Q49764|RECQ|B1937_F2_66 PUTATIVE DNA HELICASE RECQ (EC FT 3.6.1.-) (242 aa), FASTA scores: opt: 1267, E(): 1.4e-69, FT (82.5% identity in 234 aa overlap); products of two FT adjacent ORFS in Mycobacterium leprae. Also similar to FT other DNA helicases e.g. Q9FCK0|2SC3B6.12 from Streptomyces FT coelicolor (785 aa), FASTA scores: opt: 1687, E(): 1.2e-94, FT (52.05% identity in 728 aa overlap); FT P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-DEPENDENT FT DNA HELICASE PCRA from Mycobacterium tuberculosis (771 aa), FT FASTA scores: opt: 715, E(): 1e-35, (34.1% identity in 710 FT aa overlap); Q9CD72|PCRA_MYCLE|UVRD|ML0153 ATP-DEPENDENT FT DNA HELICASE PCRA from Mycobacterium leprae (778 aa), FASTA FT scores: opt: 687, E(): 5.1e-34, (32.0% identity in 719 aa FT overlap); O83991|TP1028 DNA HELICASE II (UVRD) from FT Treponema pallidum (670 aa), FASTA scores: opt: 652, E(): FT 6e-32, (30.25% identity in 671 aa overlap); etc. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO FT THE UVRD SUBFAMILY OF HELICASES." FT /db_xref="GOA:P64321" FT /db_xref="HSSP:1PJR" FT /db_xref="InterPro:IPR002121" FT /db_xref="UniProtKB/Swiss-Prot:P64321" FT /protein_id="CAD95314.1" FT /translation="MSIASDPLIAGLDDQQREAVLAPRGPVCVLAGAGTGKTRTITHRI FT ASLVASGHVAAGQVLAVTFTQRAAGEMRSRLRALDAAARTGSGVGAVQALTFHAAAYRQ FT LRYFWSRVIADTGWQLLDSKFAVVARAASRTRLHASTDDVRDLAGEIEWAKASLIGPEE FT YVTAVAAARRDPPLDAAQIAAVYSEYEALKARGDGVTLLDFDDLLLHTAAAIENDAAVA FT EEFQDRYRCFVVDEYQDVTPLQQRVLSAWLGDRDDLTVVGDANQTIYSFTGASPRFLLD FT FSRRFPDAAVVRLERDYRSTPQVVSLANRVIAAARGRVAGSKLRLSGQREPGPVPSFHE FT HSDEPAEAATVAASIARLIASGTPPSEVAILYRVNAQSEVYEEALTQAGIAYQVRGGEG FT FFNRQEIKQALLALQRVSERDTDAALSDVVRAVLAPLGLTAQPPVGTRARERWEALTAL FT AELVDDELAQRPALQLPGLLAELRRRAEARHPPVVQGVTLASLHAAKGLEWDAVFLVGL FT ADGTLPISHALAHGPNSEPVEEERRLLYVGITRARVHLALSWALSRSPGGRQSRKPSRF FT LNGIAPQTRADPVPGTSRRNRGAAARCRICNNELNTSAAVMLRRCETCAADVDEELLLQ FT LKSWRLSTAKEQNVPAYVVFTDNTLIAIAELLPTDDAALIAIPGIGARKLEQYGSDVLQ FT LVRGRT" FT CDS 82880..83134 FT /transl_table=11 FT /gene="Mb3223" FT /locus_tag="Mb3223" FT /product="POSSIBLE GLUTAREDOXIN PROTEIN" FT /EC_number="1.-.-.-" FT /note="Mb3223, -, len: 84 aa. Equivalent to Rv3198A, len: FT 84 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 84 aa overlap). Possible glutaredoxin FT protein (EC 1.-.-.-), highly similar to Q9FCK1|2SC3B6.11c FT PUTATIVE GLUTAREDOXIN-LIKE PROTEIN from Streptomyces FT coelicolor (80 aa), FASTA scores: opt: 293, E(): 2.2e-14, FT (55.15% identity in 78 aa overlap); and Q9RSN9|DR2085 FT PUTATIVE GLUTAREDOXIN from Deinococcus radiodurans (81 aa), FT FASTA scores: opt: 198, E(): 1.2e-07, (53.55% identity in FT 56 aa overlap). Also similar to several hypothetical FT bacterial proteins e.g. Q9X8C2|SCE36.09 HYPOTHETICAL 13.0 FT KDA PROTEIN from Streptomyces coelicolor (114 aa), FASTA FT scores: opt: 181, E(): 2.6e-06, (44.45% identity in 72 aa FT overlap)." FT /db_xref="GOA:Q7TX15" FT /db_xref="InterPro:IPR017937" FT /db_xref="UniProtKB/TrEMBL:Q7TX15" FT /protein_id="CAD95315.1" FT /translation="MITAALTIYTTSWCGYCLRLKTALTANRIAYDEVDIEHNRAAAEF FT VGSVNGGNRTVPTVKFADGSTLTNPSADEVKAKLVKIAG" FT CDS complement(83147..84088) FT /transl_table=11 FT /gene="nudC" FT /locus_tag="Mb3224c" FT /product="PROBABLE NADH PYROPHOSPHATASE NUDC (NAD+ FT DIPHOSPHATASE) (NAD+ PYROPHOSPHATASE) (NADP FT PYROPHOSPHATASE)" FT /EC_number="3.6.1.22" FT /note="Mb3224c, nudC, len: 313 aa. Equivalent to Rv3199c, FT len: 313 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 313 aa overlap). Probable nudC, NADH FT pyrophosphatase (EC 3.6.1.22), similar in particular to FT Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356 aa), FT FASTA scores: opt: 493, E(): 7.4e-24, (39.65% identity in FT 232 aa overlap); Q9ABG1|CC0266 MUTT/NUDIX FAMILY PROTEIN FT from Caulobacter crescentus (313 aa), FASTA scores: opt: FT 479, E(): 5.1e-23, (38.3% identity in 222 aa overlap); FT O86062|NUDC_PSEAE|NUDC|PA1823 NADH PYROPHOSPHATASE from FT Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 371,2 FT E(): 3e-16, (43.15% identity in 153 aa overlap); FT Q9RV62|NUDC_DEIRA|NUDC|DR1168 NADH PYROPHOSPHATASE from FT Deinococcus radiodurans (280 aa), FASTA scores: opt: 363, FT E(): 9.6e-16, (34.45% identity in 270 aa overlap); etc. FT Caution: equivalent to AAK47636 from Mycobacterium FT tuberculosis strain CDC1551 (386 aa) but shorter 72 aa. FT Contains PS00893 mutT domain signature. BELONGS TO THE FT NUDIX HYDROLASE FAMILY, NUDC SUBFAMILY. COFACTOR: REQUIRES FT DIVALENT IONS: MANGANESE OR MAGNESIUM." FT /db_xref="GOA:Q7TX14" FT /db_xref="InterPro:IPR015376" FT /db_xref="UniProtKB/Swiss-Prot:Q7TX14" FT /protein_id="CAD95316.1" FT /translation="MTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALL FT RVDSRNRVLVANGRVLLGAAIELADKPPPEAVFLGRVEGGRHVWAVRAALQPIADPDIP FT AEAVDLRGLGRIMDDTSSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNPITG FT HEEFPRIDPAVICLVHDGADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREE FT IGLTVRDVRYLGSQPWPFPRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALA FT AGDWSSASESKLLLPGSISIARVIIESWAACE" FT CDS complement(84147..85214) FT /transl_table=11 FT /gene="Mb3225c" FT /locus_tag="Mb3225c" FT /product="POSSIBLE TRANSMEMBRANE CATION TRANSPORTER" FT /note="Mb3225c, -, len: 355 aa. Equivalent to Rv3200c, len: FT 355 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 355 aa overlap). Possible transmembrane FT cation transporter, similar to many transmembrane proteins FT and putative potassium channels e.g. Q9XA52|SCGD3.27C FT PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (365 FT aa), FASTA scores: opt: 1022, E(): 2.6e-53, (49.85% FT identity in 325 aa overlap); Q9RRZ3|DR2336 PUTATIVE FT POTASSIUM CHANNEL from Deinococcus radiodurans (320 aa), FT FASTA scores: opt: 436, E(): 1e-18, (30.9% identity in 304 FT aa overlap); O28600|AF1673 PUTATIVE POTASSIUM CHANNEL from FT Archaeoglobus fulgidus (314 aa), FASTA scores: opt: 363, FT E(): 2.1e-14, (27.2% identity in 309 aa overlap); FT Q57604|Y13B_METJAMJ0138.1|MJ0138.1 PUTATIVE POTASSIUM FT CHANNEL from Methanococcus jannaschii (333 aa), FASTA FT scores: opt: 356, E(): 5.7e-14, (26.0% identity in 281 aa FT overlap); P73132|SLL0993 POTASSIUM CHANNEL from FT Synechocystis sp. strain PCC 6803 (365 aa), FASTA scores: FT opt: 330, E(): 2.1e-12, (27.8% identity in 324 aa overlap); FT etc. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="GOA:Q7TX13" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TX13" FT /protein_id="CAD95317.1" FT /translation="MAGSWRRLRGLDEKLTAQPGYALVGVLRIPQRRASPARVISRRVV FT VAVVALLLTAGIVYVDRDGYLDAQGDRLTFLDCLYYAAVTLSTTGYGDITPISEFARAI FT NIFVITPLRIAFLILLVGTTLEVLTETSRQAYKIQRWRSRVRNHTVVIGYGTKGKTAVA FT AMVSDELVPGEIVVVDTDSGVLERAAAAGLVTVHGDATKSDVLRLAGTQHASSIIVATS FT RDDTAVLVTLTAREIAPKAKIVASIREAENQHLLRQSGADTVVVSSETAGRLLGIATTT FT PSVVEMIEDLLTPEAGLAVAEREVEQAEVGGSPRHLRDIVLGVVRDGQLLRIGAPEVDA FT IEASDRLLYIRQVGR" FT CDS complement(85276..88581) FT /transl_table=11 FT /gene="Mb3226c" FT /locus_tag="Mb3226c" FT /product="PROBABLE ATP-DEPENDENT DNA HELICASE" FT /EC_number="3.6.1.-" FT /note="Mb3226c, -, len: 1101 aa. Equivalent to Rv3201c, FT len: 1101 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 1101 aa overlap). Probable FT ATP-dependent DNA helicase (EC 3.6.1.-), similar to others FT e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222 FT aa), FASTA scores: opt: 1209, E(): 5.4e-63, (38.45% FT identity in 1199 aa overlap); FT P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from FT Mycobacterium tuberculosis (771 aa), FASTA scores: opt: FT 403, E(): 6.5e-16, (28.15% identity in 717 aa overlap); FT Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159 aa), FT FASTA scores: opt: 349, E(): 1.3e-12, (29.2% identity in FT 1144 aa overlap); Q9L3M1|UVRD from Prochlorococcus sp. (512 FT aa; fragment), FASTA scores: opt: 290, E(): 2e-09, (27.95% FT identity in 479 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7TX12" FT /db_xref="InterPro:IPR014017" FT /db_xref="UniProtKB/TrEMBL:Q7TX12" FT /protein_id="CAD95318.1" FT /translation="MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVIAGA FT GAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGIGLGCGD FT PAACAPVVSTYHAFAGSLLRDYGLLLPLEPDTRLLSETELWQLAFDVVSGYDGVLCTDK FT SPAAVTSIVVRLWGQLGEHLVDTRALRDTHVELERLVHALPAGRYQRDRGPSQWLLRML FT ATQTQRAELVPLLDALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLD FT EYQDTGHAQRVVLSSLFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPLSD FT GTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRALRPRPDAPPGAVRCALLPDV FT QAEREWIADHLRMRYQRAEADGVKPPTAAVLVRRNADAAAIADTLRARGIPAEVVGLAG FT LLSIPEVAEVVAMLRLVADPTAGAAAMRVLTGPRWRLGARDLAALWRRALTLSGESPST FT ASPESIAMAASADADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRLGHSLP FT DLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAERASARSSEASVAGLL FT AYLDVAEVVENGLPPAELTVACDRVQVLTVHAAKGLEWQVVAVAHLSRGVFPSTVSRSS FT WLTDPAELPPLLRGDRASAGAHGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERR FT LLYVAVTRAEDTLLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWAS FT APAGDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDIDHPPRP FT GDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDPVGARQRLMCRLPKRP FT DPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADREVGDPEELAALQRAFTASSWAART FT PAAVEVPFEMPIGDTVVRGRIDAVFVDPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVY FT RLAWAALRGCPTSSVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT" FT CDS complement(88578..91745) FT /transl_table=11 FT /gene="Mb3227c" FT /locus_tag="Mb3227c" FT /product="POSSIBLE ATP-DEPENDENT DNA HELICASE" FT /EC_number="3.6.1.-" FT /note="Mb3227c, -, len: 1055 aa. Equivalent to Rv3202c, FT len: 1055 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1055 aa overlap). Possible ATP-dependent FT DNA helicase (EC 3.6.1.-), showing some similarity to UvrD FT proteins e.g. Q9FCK5|2SC3B6.07 PUTATIVE ATP-DEPENDENT DNA FT HELICASE from Streptomyces coelicolor (1159 aa), FASTA FT scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa FT overlap); Q9L7T3|UVRD|PA5443 MISMATCH REPAIR PROTEIN MUTU FT (DNA HELICASE II) from Pseudomonas aeruginosa (728 aa), FT FASTA scores: opt: 239, E(): 7.3e-06, (23.8% identity in FT 677 aa overlap) (no similarity in C-terminal part for this FT one); etc. C-terminal region similar to Q9FDU2|ORF3 ORF3 FT PROTEIN (FRAGMENT) from Streptomyces griseus (551 aa), FT FASTA scores: opt: 800, E(): 1.7e-37, (36.2% identity in FT 525 aa overlap); and Q9ZG15 HYPOTHETICAL 35.5 KDA PROTEIN FT from Rhodococcus erythropolis (323 aa), FASTA scores: opt: FT 232, E(): 9.7e-06, (28.55% identity in 266 aa overlap)." FT /db_xref="GOA:Q7TX11" FT /db_xref="InterPro:IPR014017" FT /db_xref="UniProtKB/TrEMBL:Q7TX11" FT /protein_id="CAD95319.1" FT /translation="MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLVEAAVAHIGA FT GTDPESVLLLTGSGRMGMRARSALTTALLRSRTNGPCRAAIREPVVRTVHSYAYAVLRK FT AAQRAGDALPRLLTSAEQDAIIRELLAGDAEDGPAATTTWPAHLRPALTTAGFATELRN FT LLARCAERGLDPLELQQLGRRRGRPEWIAAGQFAQRYEQVMLLRGAVGLAAPQATAPAL FT SAAELVGAALEAFAVDPELLAAERARVRTLLVDDAQQLDPQAARLVRMLAAGTELALIA FT GDPNQAVFGFRGGEPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGIARRLPG FT RSVGRRIEGTGTEVGSVTVRLAGSAHAEAAMIADALRRAHLIDGVPWSQMAVIVRSVPR FT AVRLPRALAAAGVPVAPPAVGGPLSAEPAVRALLTVLEATADGLDGDQALLLLTGPIGG FT VDPVSLRQLRRTLQRARPGQTSRKFGDLLVEVLGGDAPPSGPGSRALRRVRAVLTAAAR FT CHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAAVQATRDLETVTALFDITDH FT YVSRTSGASLRGLVEHVTALQLPVVRPEPAAPTEQVMVLSAHAALGHEWDLVVIAGLQD FT GLWPNTVPRGGVLGTQRLLDELDGVTKDASMRAPLLAEERRLLVTAMGRARRRLLVTAV FT DSDAGGGGHEAVLPSAFFFEIAQWADGDGEPVAMQPVSAPRVLSAAAVVGRLRAVVCAP FT ACAVDDADRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLCDSDDLVTLTPSTLQ FT ALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRSESQLLAELDRVWGHLPFGA FT QWYSANELARHRAMIQAFVQWRAQSRSELTEVGVEVDIDGALEDGSGQARKIRLRGRAD FT RLERDPAGRLVIVDIKTGKTPVSKDDAQQHAQLAMYQLAVAEGLVRAGDEPGGARLVYV FT GKSGAAGVAERKQDPLTPAARDEWRNLVRQLAAATAGPQFIARRNDGCTHCPLRPGCPA FT HVRGSAP" FT CDS 92182..92856 FT /transl_table=11 FT /gene="lipV" FT /locus_tag="Mb3228" FT /product="POSSIBLE LIPASE LIPV" FT /EC_number="3.1.-.-" FT /note="Mb3228, lipV, len: 224 aa. Equivalent to Rv3203, FT len: 224 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 224 aa overlap). Possible lipV, FT hydrolase lipase (EC 3.1.-.-), showing some similarity to FT other lipases e.g. Q9JSN0|NMA2216 PUTATIVE HYDROLASE from FT Neisseria meningitidis (serogroup A) (312 aa), FASTA FT scores: opt: 192, E(): 0.00016, (45.2% identity in 73 aa FT overlap); Q9RK95|SCF1.09 PUTATIVE HYDROLASE from FT Streptomyces coelicolor (258 aa), FASTA scores: opt: 188, FT E(): 0.00024, (30.1% identity in 226 aa overlap); FT Q9KZC3|SC6F7.19c PUTATIVE LIPASE from Streptomyces FT coelicolor (269 aa), FASTA scores: opt: 179, E(): 0.00086, FT (36.35% identity in 121 aa overlap); etc. Equivalent to FT AAK47641 Hydrolase, alpha/beta hydrolase family from FT Mycobacterium tuberculosis strain CDC1551 (261 aa) but FT shorter 37 aa. Contains serine active site signature of FT lipases (PS00120)." FT /db_xref="GOA:Q7TX10" FT /db_xref="InterPro:IPR000639" FT /db_xref="UniProtKB/TrEMBL:Q7TX10" FT /protein_id="CAD95320.1" FT /translation="MPEIPIAAPDLLGHGRSPWAAPWTIDANVSALAALLDNQGDGPVV FT VVGHSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDAMLASPDYLDPAEAR FT AEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRISLPAMVCYWSELARDIVLPPVGT FT ATTLVRAVRASPAYVSDQLLAALDKRLGADFELLDFDCGHMVPQAKPTEVAAVIRSRLG FT PR" FT CDS 92859..93164 FT /transl_table=11 FT /gene="Mb3229" FT /locus_tag="Mb3229" FT /product="POSSIBLE DNA-METHYLTRANSFERASE (MODIFICATION FT METHYLASE)" FT /EC_number="2.1.1.-" FT /note="Mb3229, -, len: 101 aa. Equivalent to Rv3204, len: FT 101 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.0% identity in 101 aa overlap). Possible DNA FT methyltransferase (EC 2.1.1.-), similar to many FT hypothetical bacteriel proteins and methyltransferases e.g. FT Q9KT40|VC1065 METHYLATED-DNA--PROTEIN-CYSTEINE FT METHYLTRANSFERASE-RELATED PROTEIN from Vibrio cholerae (100 FT aa), FASTA scores: opt: 170, E(): 2.8e-05, (34.35% identity FT in 99 aa overlap); Q9UTN9|SPAC1250.04c PUTATIVE FT METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission FT yeast) (108 aa), FASTA scores: opt: 161, E(): 0.00013, FT (36.65% identity in 101 aa overlap); Q9YDF4|APE0959 175 AA FT LONG HYPOTHETICAL METHYLATED-DNA--PROTEIN-CYSTEINE FT METHYLTRANSFERASE from Aeropyrum pernix (175 aa), FASTA FT scores: opt: 144, E(): 0.003, (37.95% identity in 87 aa FT overlap); Q50855 PUTATIVE METHYLGUANINE-DNA FT METHYLTRANSFERASE from Myxococcus xanthus (147 aa), FASTA FT scores: opt: 141, E(): 0.0041, (37.65% identity in 93 aa FT overlap); etc." FT /db_xref="GOA:Q7TX09" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7TX09" FT /protein_id="CAD95321.1" FT /translation="MAPVTDEQVELVRSLVAAIPLGRVSTYGDIAALAGLSSPRIVGWI FT MRTDSSDLPWHRVIRASGRPAQHLATRQLELLRAEGVLSVDGRVALSEIRYEFPPG" FT CDS complement(93171..94049) FT /transl_table=11 FT /gene="Mb3230c" FT /locus_tag="Mb3230c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3230c, -, len: 292 aa. Equivalent to Rv3205c, len: FT 292 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 292 aa overlap). Hypothetical protein, FT highly similar to Q9CCG7|ML0818 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (297 aa), FASTA scores: opt: 1745, FT E(): 9.1e-98, (87.3% identity in 291 aa overlap)." FT /db_xref="InterPro:IPR013402" FT /db_xref="UniProtKB/TrEMBL:Q7TX08" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95322.1" FT /translation="MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGEV FT VLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPRHD FT EVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGVPTA FT PPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYWRPAS FT WAAGVAVVDALSWGAADDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAEAFPGL FT AHTAALVRLVL" FT CDS complement(94076..95251) FT /transl_table=11 FT /gene="moeB1" FT /locus_tag="Mb3231c" FT /standard_name="moeZ" FT /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN FT MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE FT SULPHURYLASE)" FT /note="Mb3231c, moeB1, len: 391 aa. Equivalent to Rv3206c, FT len: 392 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 392 aa overlap). Probable moeB1, FT molybdopterin cofactor biosynthesis protein, equivalent to FT Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN FT MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 FT aa), FASTA scores: opt: 2285, E(): 3.3e-130, (86.45% FT identity in 391 aa overlap.) Very similar to members of the FT HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE FT SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA FT scores: opt: 1776, E(): 1.4e-99, (65.3% identity in 395 aa FT overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE FT SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas FT perfectomarina) (391 aa), FASTA scores: opt: 1526, E(): FT 1.5e-84, (59.1% identity in 391 aa overlap); FT O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus FT sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA FT scores: opt: 1309, E(): 1.8e-71, (52.95% identity in 387 aa FT overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS FT MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 FT aa), FASTA scores: opt: 1308, E(): 2e-71, (50.65% identity FT in 397 aa overlap); etc. Also highly similar to FT O05792|MOEB2|Rv3116|MTCY164.26 PUTATIVE MOLYBDENUM COFACTOR FT BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (389 FT aa), FASTA scores: opt: 1440, E(): 2.3e-79, (57.25% FT identity in 386 aa overlap). Has hydrophobic segment from FT ~45-71. BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that FT previously known as moeZ." FT /db_xref="GOA:Q7TX07" FT /db_xref="HSSP:1JWA" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TX07" FT /protein_id="CAD95323.1" FT /translation="MSTSLPPLVEPASALSREEVARYSRHLIIPDLGVDGQKRLKNARV FT LVIGAGGLGAPTLLYLAAAGVGTIGIVDFDVVDESNLQRQVIHGVADVGRSKAQSARDS FT IVAINPLIRVRLHELRLAPSNAVDLFKQYDLILDGTDNFATRYLVNDAAVLAGKPYVWG FT SIYRFEGQASVFWEDAPDGLGVNYRDLYPEPPPGMVPSCAEGGVLGIICASVASVMGTE FT AIKLITGIGETLLGRLLVYDALEMSYRTITIRKDPSTPKITELVDYEQFCGVVADDAAQ FT AAKGSTITPRELRDWLDSGRKLALIDVRDPVEWDIVHIDGAQLIPKSLINSGEGLAKLP FT QDRTAVLYCKTGVRSAEALAAVKKAGFSDAVHLQGGIVAWAKQMQPDMVMY" FT CDS complement(95342..96199) FT /transl_table=11 FT /gene="Mb3232c" FT /locus_tag="Mb3232c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3232c, -, len: 285 aa. Equivalent to Rv3207c, len: FT 285 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 285 aa overlap). Hypothetical protein, FT highly similar but shorter (57 aa) to Q9CCG9|ML0816 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (341 aa), FT FASTA scores: opt: 1676, E(): 9.7e-96, (81.0% identity in FT 284 aa overlap). Also similar to C-terminus of FT Q9FBI6|SCP8.36 HYPOTHETICAL PROTEIN from Streptomyces FT coelicolor (559 aa), FASTA scores: opt: 426, E(): 8.4e-19, FT (37.35% identity in 281 aa overlap); and similar to other FT hypothetical proteins (generally membrane proteins) e.g. FT Q9K456|SC2H12.28C PUTATIVE MEMBRANE PROTEIN from FT Streptomyces coelicolor (314 aa), FASTA scores: opt: 341, FT E(): 8.8e-14, (29.75% identity in 296 aa overlap). Contains FT neutral zinc metallopeptidases, zinc-binding region FT signature (PS00142)." FT /db_xref="GOA:Q7TX06" FT /db_xref="InterPro:IPR006026" FT /db_xref="UniProtKB/TrEMBL:Q7TX06" FT /protein_id="CAD95324.1" FT /translation="MSTYGWRAYALPVLMVLTTVVVYQTVTGTSTPRPAAAQTVRDSPA FT IGVVGTAILDAPPRGLAVFDANLPAGTLPDGGPFTEAGDKTWRVVPGTTPQVGQGTVKV FT FRYTVEIENGLDPTMYGGDNAFAQMVDQTLTNPKGWTHNPQFAFVRIDSGKPNFRISLV FT SPTTVRGGCGYEFRLETSCYNPSFGGMDRQSRVFINEARWVRGAVPFEGDVGSYRQYVI FT NHEVGHAIGYLRHEPCDQQGGLAPVMMQQTFSTSNDDAAKFDPDFVKADGKTCRFNPWP FT YPIP" FT CDS 96545..97231 FT /transl_table=11 FT /gene="Mb3233" FT /locus_tag="Mb3233" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /note="Mb3233, -, len: 228 aa. Equivalent to Rv3208, len: FT 228 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 228 aa overlap). Probable FT transcriptional regulator tetR family, equivalent to FT Q9CCH0|ML0815 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL FT REGULATOR from Mycobacterium leprae (228 aa), FASTA scores: FT opt: 1248, E(): 1.4e-74, (82.4% identity in 227 aa FT overlap). Also highly similar to Q9FBI8|SCP8.33c PUTATIVE FT TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces FT coelicolor (213 aa), FASTA scores: opt: 629, E(): 4e-34, FT (45.8% identity in 203 aa overlap); Q9KIL9|F58R F58R FT (FRAGMENT) from Streptomyces coelicolor A3(2) (149 aa), FT FASTA scores: opt: 497, E(): 1.3e-25, (50.35% identity in FT 147 aa overlap); Q9K3T5|SCE66.08 PUTATIVE TETR-FAMILY FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (225 FT aa), FASTA scores: opt: 344, E(): 1.8e-15, (31.15% identity FT in 212 aa overlap); Q9RYK4|DRA0308 TRANSCRIPTIONAL FT REGULATOR, TETR FAMILY from Deinococcus radiodurans (239 FT aa), FASTA scores: opt: 290, E(): 6.5e-12, (30.5% identity FT in 223 aa overlap); etc. And also similar to Mycobacterium FT tuberculosis proteins P96381|Rv1019|MTCY10G2.30c FT HYPOTHETICAL 21.7 KDA PROTEIN (197 aa), FASTA scores: opt: FT 356, E(): 2.7e-16, (34.4% identity in 189 aa overlap); FT MTV034_4; MTY07A7A_3; MTV032_1; MTCY07A7_12; etc. Contains FT probable helix-turn-helix motif at aa 60-81 (Score 1517, FT +4.35 SD). SIMILAR TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7TX05" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7TX05" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95325.1" FT /translation="MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQLL FT VVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGVHQ FT ALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCIDAV FT FALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWGGLSH FT VPLTRS" FT CDS complement(97218..97490) FT /transl_table=11 FT /gene="TB9.4" FT /locus_tag="Mb3234c" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB9.4" FT /note="Mb3234c, TB9.4, len: 90 aa. Equivalent to Rv3208A, FT len: 90 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 90 aa overlap). TB9.4, conserved FT hypothetical protein (see citations below), equivalent to FT Q9CCH1|ML0814 HYPOTHETICAL PROTEIN from Mycobacterium FT leprae (82 aa), FASTA scores: opt: 411, E(): 1.8e-22, FT (81.0% identity in 79 aa overlap). Also similar, but FT shorter in N-terminus, to Q9FBI9|SCP8.32c PUTATIVE FT ATP-BINDING PROTEIN from Streptomyces coelicolor (94 aa), FT FASTA scores: opt: 246, E(): 8.1e-11, (53.4% identity in 73 FT aa overlap); Q9DGP6 (alias Q9DGP4) GLUTAMATE DECARBOXYLASE FT 67 KDA ISOFORM (FRAGMENT) from Alepocephalus bairdii (182 FT aa), FASTA scores: opt: 100, E(): 2.6, (35.3% identity in FT 85 aa overlap). Corresponds to Statens Serum Institute FT antigen, CYP10 TB9.4. Has N-terminal sequence, FT VEVKIGITDSPRELV." FT /db_xref="UniProtKB/TrEMBL:Q7TX04" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95326.1" FT /translation="MEVKIGITDSPRELVFSSAQTPSEVEELVSNALRDDSGLLTLTDE FT RGRRFLIHTARIAYVEIGVADARRVGFGVGVDAAAGSAGKVATSG" FT CDS 97815..98375 FT /transl_table=11 FT /gene="Mb3235" FT /locus_tag="Mb3235" FT /product="CONSERVED HYPOTHETICAL THREONIN AND PROLINE RICH FT PROTEIN" FT /note="Mb3235, -, len: 186 aa. Equivalent to Rv3209, len: FT 186 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 186 aa overlap). Conserved hypothetical FT thr-, pro-rich protein, equivalent (but shorter 36 aa in FT N-terminus) to Q9CCH2|ML0813 PUTATIVE MEMBRANE PROTEIN from FT Mycobacterium leprae (195 aa), FASTA scores: opt: 508, E(): FT 1.4e-15, (58.4% identity in 185 aa overlap). Also some FT similarity with FT Q10390|MMS3_MYCTU|MMPS3|Rv2198c|MT2254|MTCY190.09c PROBABLE FT CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from M. FT tuberculosis (299 aa), FASTA scores: opt: 339, E(): FT 3.7e-08, (35.0% identity in 180 aa overlap); and FT Q9CCE9|MMPS3|ML0877 PUTATIVE MEMBRANE PROTEIN from FT Mycobacterium leprae (293 aa), FASTA scores: opt: 272, E(): FT 2.8e-05, (36.4% identity in 173 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TX03" FT /protein_id="CAD95327.1" FT /translation="MALGAVATAVIINSGDSTSTKAIVGAPAPRTVISTSPRPTAPTST FT SPHPSPSTLRPQLPPETVTTVAPPGTGPTTVPTRTPTAAPPQTAVPPPAPLNPRTVVYR FT VTGTKQLFDLVNVVYTDARGFPVTDFNVSLPWTKMVVLNPGVQTESVVATSLYSRLNCS FT IVNTGAQTVVASTNNAIIATCTR" FT CDS complement(98385..99080) FT /transl_table=11 FT /gene="Mb3236c" FT /locus_tag="Mb3236c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3236c, -, len: 231 aa. Equivalent to Rv3210c, len: FT 231 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 231 aa overlap). Conserved hypothetical FT protein, similar (but N-terminus shorter) to Q9FBJ1|SCP8.30 FT CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor FT (260 aa), FASTA scores: opt: 599, E(): 1.1e-30, (42.5% FT identity in 233 aa overlap); and some similarity to FT Q9RRV1|DR2384 PHENYLACETIC ACID DEGRADATION PROTEIN PAAC FT from Deinococcus radiodurans (263 aa), FASTA scores: opt: FT 129, E(): 0.43, (27.9% identity in 172 aa overlap); and FT Q9F621 FLGK PROTEIN from Rhizobium meliloti (Sinorhizobium FT meliloti) (472 aa)." FT /db_xref="GOA:Q7TX02" FT /db_xref="UniProtKB/TrEMBL:Q7TX02" FT /protein_id="CAD95328.1" FT /translation="MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLTD FT EARMAPDLRGRISMASMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLTTP FT STWLEALVKTYVADALAADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAAVTA FT SGKQRSRLALWSRRLLGEAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQQTHD FT QRMRELGLS" FT CDS 99339..100922 FT /transl_table=11 FT /gene="rhlE" FT /locus_tag="Mb3237" FT /product="PROBABLE ATP-DEPENDENT RNA HELICASE RHLE" FT /note="Mb3237, rhlE, len: 527 aa. Equivalent to Rv3211, FT len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 527 aa overlap). Probable rhlE, FT ATP-dependent RNA helicase, equivalent (but shorter 22 aa) FT to Q9CCH3|RHLE|ML0811 PUTATIVE ATP-DEPENDENT RNA HELICASE FT from Mycobacterium leprae (544 aa), FASTA scores: opt: FT 2497, E(): 8.7e-131, (74.75% identity in 531 aa overlap). FT Also highly similar to other RNA helicases e.g. FT Q9FBJ2|SCP8.29c from Streptomyces coelicolor (879 aa), FT FASTA scores: opt: 1458, E(): 3.6e-73, (52.5% identity in FT 522 aa overlap); Q9DF36 from Xenopus laevis (African clawed FT frog) (800 aa), FASTA scores: opt: 792, E(): 2.3e-36, FT (37.15% identity in 385 aa overlap); Q99Z38|DEAD|SPY1415 FT from Streptococcus pyogenes (759 aa), FASTA scores: opt: FT 779, E(): 1.1e-35, (37.1% identity in 380 aa overlap); FT P33906|DEAD|CSDA from Klebsiella pneumoniae (642 aa), FASTA FT scores: opt: 768, E(): 4e-35, (43.4% identity in 387 aa FT overlap); etc. Contains ATP/GTP-binding site motif A FT (PS00017) and DEAD-box subfamily ATP-dependent helicases FT signature (PS00039). SIMILAR TO DEAD/DEAH BOX HELICASE FT FAMILY AND SIMILAR TO HELICASE C-TERMINAL DOMAIN." FT /db_xref="GOA:Q7TX01" FT /db_xref="HSSP:1HV8" FT /db_xref="InterPro:IPR014001" FT /db_xref="UniProtKB/TrEMBL:Q7TX01" FT /protein_id="CAD95329.1" FT /translation="MTAVKHTTESTFAKLGARDEIVRALGEEGIKRPFAIQELTLPLAL FT DGEDVIGQARTGMGKTFAFGVPLLQRITSGDGTRPLTGAPRALVVVPTRELCLQVTDDL FT ATAGKYLTAGPDTDDAAAVRRRLSVVSIYGGRPYEPQIEALRAGADVVVGTPGRLLDLC FT QQGHLQLGGLSVLVLDEADEMLDLGFLPDIERILRQIPADRQSMLFSATMPDPIITLAR FT TFMVRPTHIRAEAPHSSAVHDATEQFVYRAHALDKVELVSRVLQARDRGATMIFTRTKR FT TAQKVADELTERGFAVGAVHGDLGQLAREKALKAFRTGGIDVLVATDVAARGIDIDDVT FT HVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELPRWSMIDQALGLGSPDPAET FT YSNSPHLYAELAIPATAGGTVGPARKSQGRRRDTDCDGQKTAQHARNTPRRRRTRGGKP FT VTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVVSGSRSGNGEAARRRRRRRRRPTH FT AQDGFAARAN" FT CDS 100935..102158 FT /transl_table=11 FT /gene="Mb3238" FT /locus_tag="Mb3238" FT /product="CONSERVED HYPOTHETICAL ALANINE VALINE RICH FT PROTEIN" FT /note="Mb3238, -, len: 407 aa. Equivalent to Rv3212, len: FT 407 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 407 aa overlap). Hypothetical ala-, FT val-rich protein, equivalent to Q9CCH4|ML0810 PUTATIVE FT MEMBRANE PROTEIN from Mycobacterium leprae (407 aa), FASTA FT scores: opt: 2158, E(): 5.3e-119, (79.85% identity in 407 FT aa overlap). Weak similarity to several eukaryotic FT transcription factors e.g. P08393|ICP0_HSV11|ICP0|IE110 FT TRANS-ACTING TRANSCRIPTIONAL PROTEIN from Herpes simplex FT virus (type 1 / strain 17) (775 aa), FASTA scores: opt: FT 115, E(): 2, (26.9% identity in 334 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TX00" FT /protein_id="CAD95330.1" FT /translation="MVKPERRTKTDIAAAATIAVVVAVAASLIWWTSDARATISRPAAV FT AVPTPAPAREVPTSLKQLWTAASPATRVPVVVGGTVATGDGRQVDGRDPATGESLWSYA FT RDTDLCGVTWVYHYAVAVYRYDRGCGQVSTIDGSTGRRGAARSGYADPRVRLFSDGTTV FT LSAGDTRLELWRSDMVRMLAYGEIDARVKPSNRGLQSGCTLESAAASSAAVSVLEACTN FT QADLRLVLLRPGKEDDEPIQRIVPEPGARPGSGARVLVVSQNNTAVYLPARSGAQPRVD FT VIDETGATVSSTLLAKPPSTSAVASRTGNLVTWWTGDALLVFDAGNLTQRYTIAAGETT FT APVGPGVMMAGQLLVPVTGGIGVYDPVSGANNRYIPVTRPPSTSAVIPAVSGSRVIEQR FT GDTLVALG" FT CDS complement(102235..103035) FT /transl_table=11 FT /gene="Mb3239c" FT /locus_tag="Mb3239c" FT /product="POSSIBLE SOJ/PARA-RELATED PROTEIN" FT /note="Mb3239c, -, len: 266 aa. Equivalent to Rv3213c, len: FT 266 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.624% identity in 266 aa overlap). Possible FT soj/parA-related protein, very similar in particular to FT Soj/ParA proteins (and relatives) from Bacillus subtilis FT that inhibit the initiation of sporulation by preventing FT phosphorylation of Spo0A (see first citation below for more FT information) e.g. Q9S228|SCI51.12c from Streptomyces FT coelicolor (340 aa), FASTA scores: opt: 746, E(): 1.6e-40, FT (48.2% identity in 249 aa overlap); Q9HT11|SOJ|PA5563 from FT Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 649, FT E(): 2.1e-34, (42.2% identity in 256 aa overlap); FT Q9PB62|XF2282 from Xylella fastidiosa (264 aa), FASTA FT scores: opt: 624, E(): 8.3e-33, (42.25% identity in 251 aa FT overlap); Q9K5N0|SOJ_BACHD|SOJ|BH4058 from Bacillus FT halodurans (253 aa), FASTA scores: opt: 621, E(): 1.2e-32, FT (41.55% identity in 248 aa overlap); P37522|SOJ_BACSU (253 FT aa), FASTA scores: opt: 620, E(): 1.4e-32, (41.65% identity FT in 245; etc. Also similar to various mycobacterial FT proteins: U00021_10 from Mycobacterium leprae, MTCI125_29 FT from Mycobacterium tuberculosis, MLCB1351_6 from FT Mycobacterium leprae, MTV028_9c|Rv3918c|PARA PROBABLE FT CHROMOSOME PARTITIONING PROTEIN from Mycobacterium FT tuberculosis, MSGDNAB_18 from Mycobacterium leprae. SEEMS FT TO BELONG TO THE PARA FAMILY." FT /db_xref="GOA:Q7TWZ9" FT /db_xref="InterPro:IPR002586" FT /db_xref="UniProtKB/TrEMBL:Q7TWZ9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95331.1" FT /translation="MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQG FT CLTFSLGQDPDKLPVSVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMRAG FT REYALKRALAKFSDRFDVVIIDCPPSLGVLTLNGLTAADEAIVPLQCEMLAHRGVGQFL FT RTVADVQQITNPNLRLLGALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTVRFAE FT ASASGSSVMAGRKNKGAVAYRELAQALLKHWKTGRPLPTFTVDL" FT CDS 103189..103800 FT /transl_table=11 FT /gene="gpm2" FT /locus_tag="Mb3240" FT /product="POSSIBLE PHOSPHOGLYCERATE MUTASE GPM2 FT (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)" FT /EC_number="5.4.2.1" FT /note="Mb3240, gpm2, len: 203 aa. Equivalent to Rv3214, FT len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 203 aa overlap). Possible gpm2, FT phosphoglycerate mutase (EC 5.4.2.1), similar to many FT mutases especially phosphoglycerate mutases e.g. FT Q9F3H5|2SCC13.14c PUTATIVE MUTASE from Streptomyces FT coelicolor (198 aa), FASTA scores: opt: 487, E(): 4.4e-25, FT (42.25% identity in 194 aa overlap); BAB49378|MLL2186 FT PROBABLE PHOSPHOGLYCERATE MUTASE from Rhizobium loti FT (Mesorhizobium loti) (193 aa), FASTA scores: opt: 423, E(): FT 7e-21, (41.2% identity in 182 aa overlap); Q9RKV8|SC9G1.08c FT PUTATIVE PHOSPHATASE from Streptomyces coelicolor (199 aa), FT FASTA scores: opt: 419, E(): 1.3e-20, (41.1% identity in FT 185 aa overlap); Q9RDL0|SCC123.14c PUTATIVE FT PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 FT aa), FASTA scores: opt: 240, E(): 8.8e-09, (36.9% identity FT in 168 aa overlap); Q9X194|TM1374 PHOSPHOGLYCERATE MUTASE FT from Thermotoga maritima (201 aa), FASTA scores: opt: 218, FT E(): 2.3e-07, (33.15% identity in 202 aa overlap); etc. But FT N-terminus also similar to Q9CCH5|ENTC|ML0808 PUTATIVE FT ISOCHORISMATE SYNTHASE from Mycobacterium leprae (577 aa), FT FASTA scores: opt: 346, E(): 2.1e-15, (55.05% identity in FT 109 aa overlap). N-terminus shows also some similarity with FT other M. tuberculosis proteins e.g. MTCY427.09c; FT MTCY20G9.15; MTCY428.28. Equivalent to AAK47652 from FT Mycobacterium tuberculosis strain CDC1551 (228 aa) but FT shorter 25 aa. Note that previously known as entD." FT /db_xref="GOA:Q7TWZ8" FT /db_xref="HSSP:1EBB" FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/TrEMBL:Q7TWZ8" FT /protein_id="CAD95332.1" FT /translation="MGVRNHRLLLLRHGETAWSTLGRHTGGTEVELTDTGRTQAELAGQ FT LLGELELDDPIVICSPRRRTLDTAKLAGLTVNEVTGLLAEWDYGSYEGLTTPQIRESEP FT DWLVWTHGCPAGESVAQVNDRADSAVALALEHMSSRDVLFVSHGHFSRAVITRWVQLPL FT AEGSRFAMPTASIGICGFEHGVRQLAVLGLTGHPQPIAAG" FT CDS 103797..104915 FT /transl_table=11 FT /gene="entC" FT /locus_tag="Mb3241" FT /product="PROBABLE ISOCHORISMATE SYNTHASE ENTC FT (ISOCHORISMATE HYDROXYMUTASE) (ENTEROCHELIN BIOSYNTHESIS)" FT /EC_number="5.4.99.6" FT /note="Mb3241, entC, len: 372 aa. Equivalent to Rv3215, FT len: 372 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 372 aa overlap). Probable entC, FT isochorismate synthase (EC 5.4.99.6), equivalent to FT Q9CCH5|ENTC|ML0808 PUTATIVE ISOCHORISMATE SYNTHASE from FT Mycobacterium leprae (577 aa), FASTA scores: opt: 1817, FT E(): 5.5e-105, (73.5% identity in 366 aa overlap). Also FT similar to others e.g. Q9F639|MXCD PROTEIN INVOLVED IN FT MYXOCHELIN-TYPE IRON CHELATOR BIOSYNTHESIS (see citation FT below) from Stigmatella aurantiaca (408 aa), FASTA scores: FT opt: 893, E(): 6.2e-48, (41.6% identity in 382 aa overlap); FT P45744|DHBC_BACSU ISOCHORISMATE SYNTHASE from Bacillus FT subtilis (398 aa), FASTA scores: opt: 883, E(): 2.5e-47, FT (40.45% identity in 393 aa overlap); Q9KI93|CSBC FT ISOCHORISMATE SYNTHASE (FRAGMENT) from Azotobacter FT vinelandii (361 aa), FASTA scores: opt: 794, E(): 7.6e-42, FT (45.65% identity in 298 aa overlap); and the two FT Escherichia coli proteins AAG54928|ENTC (alias FT BAB34055|ECS0632) ISOCHORISMATE HYDROXYMUTASE 2 from FT Escherichia coli strain O157:H7 (391 aa), FASTA scores: FT opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap); FT P10377|ENTC|B0593 ISOCHORISMATE SYNTHASE from Escherichia FT coli strain K12 (391 aa), FASTA scores: opt: 744, E(): FT 1e-38, (38.8% identity in 340 aa overlap); etc. Stronger FT similarity to Escherichia coli entC. Also similar to FT MTCY253.35." FT /db_xref="GOA:Q7TWZ7" FT /db_xref="HSSP:1K0G" FT /db_xref="InterPro:IPR005801" FT /db_xref="UniProtKB/TrEMBL:Q7TWZ7" FT /protein_id="CAD95333.1" FT /translation="MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSG FT TAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTRIG FT RARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSAGND FT DTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQL FT VVDTMRVALEPLCEDLTIPAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTP FT AVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHA FT GGGIVAESDPDDELEETTTKFATILTALGVEQ" FT CDS 105063..105395 FT /transl_table=11 FT /gene="Mb3242" FT /locus_tag="Mb3242" FT /product="POSSIBLE ACETYLTRANSFERASE" FT /EC_number="2.3.1.-" FT /note="Mb3242, -, len: 110 aa. Equivalent to Rv3216, len: FT 110 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 110 aa overlap). Possible FT acetyltransferase (2.3.1.-), similar but shorter to many FT e.g. Q9AB32|CC0402 ACETYLTRANSFERASE (GNAT FAMILY) from FT Caulobacter crescentus (159 aa), FASTA scores: opt: 325, FT E(): 3.8e-17, (45.65% identity in 103 aa overlap); FT P79081|ATS1 PUTATIVE ACETYLTRANSFERASE ATS1 from FT Schizosaccharomyces pombe (Fission yeast) (168 aa), FASTA FT scores: opt: 313, E(): 3.1e-16, (47.6% identity in 105 aa FT overlap); Q9I640|PA0478 PROBABLE N-ACETYLTRANSFERASE from FT Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 308, FT E(): 6.9e-16, (50.0% identity in 98 aa overlap); Q9KHE3 FT PUTATIVE ACETYLTRANSFERASE from Anabaena sp. strain PCC FT 7120 (164 aa), FASTA scores: opt: 269, E(): 5.4e-13, FT (41.75% identity in 103 aa overlap); etc. Also some FT similarity to diamine acetyltransferases (EC 2.3.1.57) e.g. FT Q28999|ATDA_PIG|SAT from Sus scrofa (Pig) (171 aa), FASTA FT scores: opt: 152, E(): 0.00025, (23.15% identity in 108 aa FT overlap)." FT /db_xref="GOA:Q7TWZ6" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q7TWZ6" FT /protein_id="CAD95334.1" FT /translation="MRGHVAEVNGGVAAMALWFLNFSTWDGVAGIYVEDLFVWPRFRRR FT GLARGLLSTLARECVDNRYTRLAWSVLNWNSDAIALYDRIGGQPQHEWTIYRLSGPRLA FT ALAAPR" FT CDS complement(105347..105778) FT /transl_table=11 FT /gene="Mb3243c" FT /locus_tag="Mb3243c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb3243c, -, len: 143 aa. Equivalent to Rv3217c, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 143 aa overlap). Probable conserved FT integral membrane protein, equivalent (highly similar but FT shorter 30 aa) to Q9CCH6|ML0806 PUTATIVE MEMBRANE PROTEIN FT from Mycobacterium leprae (173 aa). Also similar to others FT e.g. Q9F3L9|2SC7G11.04 PUTATIVE INTEGRAL MEMBRANE PROTEIN FT from Streptomyces coelicolor (152 aa), FASTA scores: opt: FT 177, E(): 0.00024, (33.8% identity in 136 aa overlap). And FT shows similarity to O34238|MVIN|VC0680 VIRULENCE FACTOR FT MVIN HOMOLOG from Vibrio (525 aa), FASTA scores: opt: 126, FT E(): 0.97, (30.9% identity in 68 aa overlap). First GTG FT taken." FT /db_xref="UniProtKB/TrEMBL:Q7TWZ5" FT /protein_id="CAD95335.1" FT /translation="MPVRAPAAVRGAGLIVAVQGGAALVVAAALLVRGLAGADQHIVNG FT LGTAGWFVLVGGAVLAAGCRLAVGKLWGRGLAVFAQLLLLPVAWYLIVGSHQPAIGIPV FT GIIALGVLVLLFSPPSIRWAAGRDQRGAASAANRGPDSR" FT CDS 106067..107032 FT /transl_table=11 FT /gene="Mb3244" FT /locus_tag="Mb3244" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3244, -, len: 321 aa. Equivalent to Rv3218, len: FT 321 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 321 aa overlap). Conserved hypothetical FT protein, similar to several hypothetical bacterial proteins FT e.g. Q9F3M0|2SC7G11.03c from Streptomyces coelicolor (322 FT aa), FASTA scores: opt: 694, E(): 4.2e-35, (39.95% identity FT in 328 aa overlap); Q9A0J4|SPY0752 from Streptomyces FT pyogenes (340 aa), FASTA scores: opt: 187, E(): 0.00033, FT (30.5% identity in 141 aa overlap); O31502|YERQ from FT Bacillus subtilis (303 aa), FASTA scores: opt: 184, E(): FT 0.00045, (34.15% identity in 126 aa overlap); etc." FT /db_xref="GOA:Q7TWZ4" FT /db_xref="InterPro:IPR001206" FT /db_xref="UniProtKB/TrEMBL:Q7TWZ4" FT /protein_id="CAD95336.1" FT /translation="MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGTE FT LGQAAVADGVDLVVVHGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLARAL FT GISADPIAATNQLIQLLDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVEAER FT DKGGKVTAWRYIRAAVRAVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTYANNR FT PVWTNPDCRFESGLGVFATTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVACLRVTS FT MGPPIASQFDGDYLGVRETMTFRAVPDALAVVAPPARKRI" FT CDS 107312..107566 FT /transl_table=11 FT /gene="whiB1" FT /locus_tag="Mb3245" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT WHIB-LIKE WHIB1" FT /note="Mb3245, whiB1, len: 84 aa. Equivalent to Rv3219, FT len: 84 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 84 aa overlap). Probable whiB1, FT WhiB-like regulatory protein (see citation below), similar FT to WhiB paralogue of Streptomyces coelicolor. Equivalent to FT Q9CCH7|WHIB1|ML0804 PUTATIVE TRANSCRIPTIONAL REGULATOR from FT Mycobacterium leprae (84 aa), FASTA scores: opt: 580, E(): FT 3.5e-35, (95.25% identity in 84 aa overlap). Highly similar FT to several e.g. Q9X952|WBLE DEVELOPMENTAL REGULATORY FT PROTEIN WHIB-PARALOG from Streptomyces coelicolor (85 aa), FT FASTA scores: opt: 477, E(): 9.2e-28, (75.3% identity in 81 FT aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN FT from Streptomyces coelicolor (102 aa), FASTA scores: opt: FT 383, E(): 6.1e-21, (60.75% identity in 79 aa overlap); FT Q9K4K8|SC5F8.16c from Streptomyces coelicolor (83 aa), FT FASTA scores: opt: 346, E(): 2.5e-18, (54.75% identity in FT 84 aa overlap); etc." FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q7TWZ3" FT /protein_id="CAD95337.1" FT /translation="MDWRHKAVCRDEDPELFFPVGNSGPALAQIADAKLVCNRCPVTTE FT CLSWALNTGQDSGVWGGMSEDERRALKRRNARTKARTGV" FT CDS complement(107628..109133) FT /transl_table=11 FT /gene="Mb3246c" FT /locus_tag="Mb3246c" FT /product="PROBABLE TWO COMPONENT SENSOR KINASE" FT /EC_number="2.7.3.-" FT /note="Mb3246c, -, len: 501 aa. Equivalent to Rv3220c, len: FT 501 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 501 aa overlap). Probable sensor FT (probably histidine kinase), equivalent to Q9CCH8|ML0803 FT PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from FT Mycobacterium leprae (500 aa). Similar to others e.g. FT Q9F3M1|2SC7G11.01 PUTATIVE HISTIDINE KINASE (FRAGMENT) from FT Streptomyces coelicolor (372 aa), FASTA scores: opt: 1038, FT E(): 7.4e-56, (48.95% identity in 380 aa overlap); FT Q9A3K5|CC3198 SENSOR HISTIDINE KINASE from Caulobacter FT crescentus (327 aa), FASTA scores: opt: 311, E(): 1.2e-11, FT (33.35% identity in 201 aa overlap) (similarity only in FT C-terminal part for this one); Q9A2T2|CC3474 PUTATIVE FT SENSOR HISTIDINE KINASE from Caulobacter crescentus (547 FT aa); etc. C-terminal half shows similarity to many sensor FT proteins, that respond to various stimuli from FT Methanobacterium thermoautotrophicum e.g. O26568|MTH468 FT SENSORY TRANSDUCTION HISTIDINE KINASE (554 aa), FASTA FT scores: opt: 425, E(): 2.1e-18, (34.0% identity in 244 aa FT overlap); O26546|MTH446 SENSORY TRANSDUCTION REGULATORY FT PROTEIN (583 aa), FASTA scores: opt: 380, E(): 1.2e-15, FT (37.15% identity in 202 aa overlap); O26913|MTH823 SENSORY FT TRANSDUCTION REGULATORY PROTEIN (677 aa), FASTA scores: FT opt: 375, E(): 2.7e-15, (35.4% identity in 195 aa overlap); FT etc. SEEMS SIMILAR TO OTHER PROKARYOTIC SENSORY FT TRANSDUCTION HISTIDINE KINASES." FT /db_xref="GOA:Q7TWZ2" FT /db_xref="InterPro:IPR013656" FT /db_xref="UniProtKB/TrEMBL:Q7TWZ2" FT /protein_id="CAD95338.1" FT /translation="MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVR FT RNDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQNSC FT QHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEGTFP FT DAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPL FT ISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDV FT TEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVS FT SIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLDSDRATAL FT IMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSL FT GLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML" FT CDS complement(109150..109365) FT /transl_table=11 FT /gene="TB7.3" FT /locus_tag="Mb3247c" FT /product="BIOTINYLATED PROTEIN TB7.3" FT /note="Mb3247c, TB7.3, len: 71 aa. Equivalent to Rv3221c, FT len: 71 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 71 aa overlap). Biotinylated protein FT TB7.3 (see citation below), equivalent (appears to have one FT additional residue) to Q9CCH9|ML0802|BTB7_MYCLE FT BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium FT leprae (70 aa), FASTA scores: opt: 367, E(): 4e-18, (90.0% FT identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM BIOTINYLATED FT PROTEIN TB7.3 HOMOLOG from Mycobacterium smegmatis (70 aa), FT FASTA scores: opt: 341, E(): 2.1e-16, (84.05% identity in FT 69 aa overlap). Similar to C-terminal part of various FT proteins e.g. Q9HPP8|ACC|VNG1532G BIOTIN CARBOXYLASE from FT Halobacterium sp. strain NRC-1 (610 aa), FASTA scores: opt: FT 212, E(): 4e-07, (50.0% identity in 68 aa overlap); FT Q58628|PYCB_METJA|MJ1231 PYRUVATE CARBOXYLASE SUBUNIT B FT from Methanococcus jannaschii (567 aa), FASTA scores: opt: FT 192, E(): 7.8e-06, (44.8% identity in 58 aa overlap); FT Q9ZAA7|GCDC GLUTACONYL-COA DECARBOXYLASE GAMMA SUBUNIT from FT Acidaminococcus fermentans (145 aa), FASTA scores: opt: FT 184, E(): 8.9e-06, (39.4% identity in 66 aa overlap); etc." FT /db_xref="HSSP:1IYU" FT /db_xref="InterPro:IPR000089" FT /db_xref="UniProtKB/Swiss-Prot:P0A511" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95339.1" FT /translation="MAEDVRAEIVASVLEVVVNEGDQIDKGDVVVLLESMKMEIPVLAE FT AAGTVSKVAVSVGDVIQAGDLIAVIS" FT CDS complement(109650..109955) FT /transl_table=11 FT /gene="Mb3248c" FT /locus_tag="Mb3248c" FT /product="POSSIBLE ANTI-SIGMA FACTOR" FT /note="Mb3248c, -, len: 101 aa. Equivalent to Rv3221A, len: FT 101 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 101 aa overlap). Possible anti-sigma FT factor, similar to Q9XCD7|AAD41811.1 unknown protein from FT Mycobacterium smegmatis, linked to sigma factor sigH (see FT first citation below) (101 aa), FASTA scores: opt: 422, FT E(): 3.4e-22, (64.9% identity in 94 aa overlap); and to FT Q9RL96|RsrA anti-sigma factor from Streptomyces coelicolor FT (see second citation) (105 aa), FASTA scores: opt: 163, FT E(): 0.00016, (32.05% identity in 78 aa overlap)." FT /db_xref="InterPro:IPR014295" FT /db_xref="UniProtKB/TrEMBL:Q7TWZ1" FT /protein_id="CAD95340.1" FT /translation="MSENCGPTDAHADHDDSHGGMGCAEVIAEVWTLLDGECTPETRER FT LRRHLEACPGCLRHYGLEERIKALIGTKCRGDRAPEGLRERLRLEIRRTTIIRGGP" FT CDS complement(109952..110503) FT /transl_table=11 FT /gene="Mb3249c" FT /locus_tag="Mb3249c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3249c, -, len: 183 aa. Equivalent to Rv3222c, len: FT 183 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 183 aa overlap). Hypothetical protein, FT with some similarity to Q9SZD2|F19B15.50|AT4G29020 FT GLYCINE-RICH PROTEIN LIKE from Arabidopsis thaliana FT (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): FT 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 FT PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces FT coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6, FT (36.25% identity in 149 aa overlap); etc. Also some FT similarity to other hypothetical Mycobacterium tuberculosis FT proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA FT scores: opt: 141, E(): 0.5, (31.2% identity in 170 aa FT overlap); AAK45760|MT1497.1 PE_PGRS FAMILY PROTEIN from FT strain CDC1551 (1408 aa), FASTA scores: opt: 137, E(): 2, FT (31.75% identity in 148 aa overlap); etc." FT /db_xref="UniProtKB/TrEMBL:Q7TWZ0" FT /protein_id="CAD95341.1" FT /translation="MSSPVSSRRLANLVKESLQGSVLGGVVSDAVLPAVSDDVKPGAGE FT DAYRVPVVVAAGSGAVVQVGGLEVGSAAVAGEVADTVAELFVCRPTEPDVGDFVGLAGG FT AGDAGQAGQQFGLGVGVRGESFGARRRLALSTVGASGATAGLRKTHDGHHGCQARGALT FT QRRLYIGNPSEITDTRMVHQ" FT CDS complement(110500..111150) FT /transl_table=11 FT /gene="sigH" FT /locus_tag="Mb3250c" FT /standard_name="rpoE" FT /product="ALTERNATIVE RNA POLYMERASE SIGMA-E FACTOR FT (SIGMA-24) SIGH (RPOE)" FT /note="Mb3250c, sigH, len: 216 aa. Equivalent to Rv3223c, FT len: 216 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 216 aa overlap). sigH (alternate gene FT name: rpoE), alternative RNA polymerase sigma factor (see FT citations below), similar to many e.g. Q9XCD8|SIGH from FT Mycobacterium smegmatis (215 aa), FASTA scores: opt: 1187, FT E(): 8.1e-69, (87.75% identity in 212 aa overlap); FT O87834|SIGR from Streptomyces coelicolor (227 aa), FASTA FT scores: opt: 913, E(): 2.6e-51, (68.8% identity in 202 aa FT overlap); O68520|RPOE1 from Myxococcus xanthus (213 aa), FT FASTA scores: opt: 452, E(): 6.7e-22, (42.8% identity in FT 187 aa overlap); Q06198|RPSH_PSEAE|ALGU|ALGT|PA0762 from FT Pseudomonas aeruginosa (193 aa), FASTA scores: opt: 301, FT E(): 2.7e-12, (29.9% identity in 194 aa overlap); etc. FT Equivalent to AAK47662 RNA polymerase sigma-70 factor from FT Mycobacterium tuberculosis strain CDC1551 (284 aa), but FT shorter 68 aa. Has sigma-70 factors ECF subfamily signature FT (PS01063). So BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF FT SUBFAMILY. Start chosen on basis of similarity, other FT potential starts upstream." FT /db_xref="GOA:P66808" FT /db_xref="HSSP:1OR7" FT /db_xref="InterPro:IPR013249" FT /db_xref="UniProtKB/Swiss-Prot:P66808" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95342.1" FT /translation="MADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGAL FT RMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPAEY FT PTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYADVEG FT FPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS" FT CDS 111450..112298 FT /transl_table=11 FT /gene="Mb3251" FT /locus_tag="Mb3251" FT /product="POSSIBLE SHORT-CHAIN DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3251, -, len: 282 aa. Equivalent to Rv3224, len: FT 282 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 282 aa overlap). Probable FT oxidoreductase, possible short-chain FT dehydrogenase/reductase (EC 1.-.-.-), highly similar to FT BAB49551|MLL2413 HYPOTHETICAL PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, FT E(): 6.4e-59, (57.95% identity in 276 aa overlap); FT Q9AB34|CC0400 SHORT CHAIN DEHYDROGENASE FAMILY PROTEIN from FT Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, FT E(): 8.5e-59, (55.9% identity in 281 aa overlap); and FT Q9VB10|CG5590 HYPOTHETICAL PROTEIN (SIMILAR TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from FT Drosophila melanogaster (Fruit fly) (412 aa), FASTA scores: FT opt: 966, E(): 2.5e-53, (52.15% identity in 278 aa FT overlap). Similar to various proteins (principaly FT oxidoreductases) e.g. Q18639|C45B11.3 HYPOTHETICAL PROTEIN FT (SIMILAR TO THE SDR FAMILY) from Caenorhabditis elegans FT (293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3% FT identity in 271 aa overlap); Q9HZV5|PA2892 PROBABLE FT SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (274 FT aa), FASTA scores: opt: 847, E(): 5.1e-46, (49.25% identity FT in 274 aa overlap); Q9I6V0|PA0182 PROBABLE SHORT-CHAIN FT DEHYDROGENASE (SIMILAR TO THE SDR FAMILY) from Pseudomonas FT aeruginosa (250 aa), FASTA scores: opt: 333, E(): 8.3e-14, FT (29.8% identity in 245 aa overlap); Q9HY98|PA3511 PROBABLE FT SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (253 FT aa), FASTA scores: opt: 330, E(): 1.3e-13, (31.2% identity FT in 250 aa overlap); etc. Related proteins in Mycobacterium FT tuberculosis include MTCY02B10.14, MTCY369.14, and FT MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017) FT near C-terminus. MAY BE BELONG TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7TWY9" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TWY9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95343.1" FT /translation="MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPKL FT PGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINLGS FT ITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPILLEKKWLRPTAYM FT MAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKPEVYAD FT AAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLP FT A" FT CDS 112234..112422 FT /transl_table=11 FT /gene="Mb3252" FT /locus_tag="Mb3252" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3252, -, len: 62 aa. Equivalent to Rv3224A, len: FT 62 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 62 aa overlap). Conserved hypothetical FT protein (possibly gene fragment), overlaps Rv3224. Similar FT to N-terminus of ML0799|AL583919_131 conserved hypothetical FT protein from Mycobacterium leprae (135 aa), FASTA scores: FT opt: 104, E(): 0.78, (59.37% identity in 32 aa overlap). FT Note that upstream ORF Rv3224B is similar to C-terminus of FT ML0799. There appears to be no frameshift as sequence is FT identical in strain CDC1551 and in Mycobacterium bovis." FT /db_xref="UniProtKB/TrEMBL:Q7TWY8" FT /protein_id="CAD95344.1" FT /translation="MRRSASTCGWKTPTRRGTSRPSDSKTLILELPDERAVAIVPVPSK FT LSLKAAGGPRGAQSGHG" FT CDS 112400..112618 FT /transl_table=11 FT /gene="Mb3253" FT /locus_tag="Mb3253" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3253, -, len: 72 aa. Equivalent to Rv3224B, len: FT 72 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 72 aa overlap). Conserved hypothetical FT protein (possibly gene fragment), similar to C-terminal FT part of ML0799|AL583919_131 conserved hypothetical protein FT from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, FT E(): 2e-09, (60.00% identity in 70 aa overlap). Note that FT downstream ORF Rv3224A is similar to N-terminus of ML0799. FT There appears to be no frameshift as sequence is identical FT in strain CDC1551 and in Mycobacterium bovis." FT /db_xref="HSSP:1DBX" FT /db_xref="InterPro:IPR007214" FT /db_xref="UniProtKB/TrEMBL:Q7TWY7" FT /protein_id="CAD95345.1" FT /translation="MPKAAMAKPAAAEQATGYVVGGISPFGQRKRLRTVVDVSALSWDR FT VLRCRQTALGRHGGPAGPDHLDQRDHR" FT CDS complement(112615..114039) FT /transl_table=11 FT /gene="Mb3254c" FT /locus_tag="Mb3254c" FT /product="POSSIBLE TRANSFERASE" FT /EC_number="2.-.-.-" FT /note="Mb3254c, -, len: 474 aa. Equivalent to Rv3225c, len: FT 474 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 474 aa overlap). Possible transferase FT (EC 2.-.-.-). C-terminal part shows some similarity to FT various bacterial proteins e.g. BAB49093|MLL1809 FT HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium FT loti) (298 aa), FASTA scores: opt: 557, E(): 2.8e-26, FT (34.55% identity in 295 aa overlap); P14509|KKA8_ECOLI|APHA FT AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Escherichia coli FT (271 aa), FASTA scores: opt: 194, E(): 0.00018, (27.75% FT identity in 227 aa overlap); Q53826|CPH CAPREOMYCIN FT PHOSPHOTRANSFERASE from Streptomyces capreolus (281 aa), FT FASTA scores: opt: 178, E(): 0.0017, (30.5% identity in 269 FT aa overlap); Q9CDM4|YWIA UNKNOWN PROTEIN from Lactococcus FT lactis (subsp. lactis) (Streptococcus lactis) (213 aa), FT FASTA scores: opt: 167, E(): 0.0061, (2705% identity in 149 FT aa overlap); Q9X843|SC9B1.24 PUTATIVE TRANSFERASE FT (FRAGMENT) from Streptomyces coelicolor (317 aa), FASTA FT scores: opt: 165, E(): 0.011, (26.05% identity in 280 aa FT overlap); etc. Start uncertain." FT /db_xref="GOA:Q7TWY6" FT /db_xref="InterPro:IPR002575" FT /db_xref="UniProtKB/TrEMBL:Q7TWY6" FT /protein_id="CAD95346.1" FT /translation="MRFAKLSDGLSDGIVTLSPLCLDDVDAHLAGGDERLVRWLSGMPS FT TRASVEAYIRHCREQWVTGGPLRSFGIRTVAETIVGTIDLRFDGEGLASGQVNVAYGLY FT PSWRGRGLATRAVDLVCQYAAEHGATEAVIKVEPENSASARVALRAGFAFVRRICEQDG FT TVFDRYERVLRAKMHADEVDIDEDLVRRLLRAQFPQWADLPIAPVRSAGTDNAMYRLGE FT DLAVRIPRIGWAIESLRTEQQWLPRIAAHLGVASPVPVGLGSPAEGFGWPWSVCRWVAG FT ENPSAAEFVEPNRAVEDLADFITTLRATDPMGGPPAKRGAPLGEQDAEVRAALAALDGI FT IDVHAATAAWESALRVPPYAGPPMWFHGDLSRFNILTAQGRLTGVIDFGLMGVGDPSVD FT LIIAWNLLSAPARAQFRVAVGAADDDWMRGRGRALAIALIALPYYQDTNPPLAASARYA FT IGEVLADFRYGARPGC" FT CDS complement(114163..114921) FT /transl_table=11 FT /gene="Mb3255c" FT /locus_tag="Mb3255c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3255c, -, len: 252 aa. Equivalent to Rv3226c, len: FT 252 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 252 aa overlap). Conserved hypothetical FT protein, similar to various hypothetical bacterial proteins FT e.g. Q9CCI2|ML0793 PUTATIVE BACTERIOPHAGE PROTEIN from FT Mycobacterium leprae (252 aa), FASTA scores: opt: 1183, FT E(): 3.8e-68, (70.65% identity in 252 aa overlap); FT BAB54183|MLR7795 HYPOTHETICAL PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (369 aa), FASTA scores: opt: 417, E(): FT 2.9e-19, (33.75% identity in 252 aa overlap); O64131 YOQW FT PROTEIN from Bacteriophage SPBc2 (224 aa), FASTA scores: FT opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); FT O31916 YOQW PROTEIN from Bacillus subtilis (224 aa), FASTA FT scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa FT overlap); O34906 YOAM PROTEIN from Bacillus subtilis (227 FT aa), FASTA scores: opt: 401, E(): 2e-18, (37.7% identity in FT 244 aa overlap); Q9K4A5|SC7E4.11 HYPOTHETICAL 30.8 KDA FT PROTEIN from Streptomyces coelicolor (271 aa), FASTA FT scores: opt: 383, E(): 3.3e-17, (39.6% identity in 283 aa FT overlap); etc." FT /db_xref="InterPro:IPR003738" FT /db_xref="UniProtKB/TrEMBL:Q7TWY5" FT /protein_id="CAD95347.1" FT /translation="MCGRFAVTTDPAQLAEKITAIDEATGCGGGKTSYNVAPTDTIATV FT VSRHSEPDDEPTRRVRLMRWGLIPSWIKAGPGGAPDAKGPPLINARADKVATSPAFRSA FT VRSKRCLVPMDGWYEWRVDPDATPGRPNAKTPFFLHRHDGALLFTAGLWSVWKSYRSAP FT PLLSCTVITTDAVGELAEIHDRMPLLLAEEDWDDWLNPDAPPDPELLARPPDVRDIALR FT QVSTLVNNVRNNGPELLEPARSQPEQIQLL" FT CDS 114976..116328 FT /transl_table=11 FT /gene="aroA" FT /locus_tag="Mb3256" FT /product="3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE AROA FT (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP FT SYNTHASE) (EPSPS)" FT /EC_number="2.5.1.19" FT /note="Mb3256, aroA, len: 450 aa. Equivalent to Rv3227, FT len: 450 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 450 aa overlap). aroA, FT 3-phosphoshikimate 1-carboxyvinyl transferase (EC 2.5.1.19) FT (see citation below), equivalent (but C-terminus longer) to FT Q9CCI3|AROA|ML0792 PUTATIVE 3-PHOSPHOSHIKIMATE FT 1-CARBOXYVINYL TRANSFERASE from Mycobacterium leprae (430 FT aa), FASTA scores: opt: 1466, E(): 1.4e-78, (55.05% FT identity in 427 aa overlap). Contains PS00885 EPSP synthase FT signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY." FT /db_xref="GOA:Q7TWY4" FT /db_xref="HSSP:1G6S" FT /db_xref="InterPro:IPR006264" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWY4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95348.1" FT /translation="MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGRGAST FT ISGALRSRDTELMLDALQTLGLRVDGVGSELTVSGRIEPGPGARVDCGLAGTVLRFVPP FT LAALGSVPVTFDGDQQARGRPIAPLLDALRELGVAVDGTGLPFRVHGNGSLAGGTVAID FT ASASSQFVSGLLLSAASFTDGLTVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRW FT QVRPGPVAARRWDIEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLN FT AVVIHADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIAHLRGH FT ETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHRMAMAGAIIGLRVAG FT VEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPRSGQRARRATGQGSGG" FT CDS 116325..117317 FT /transl_table=11 FT /gene="Mb3257" FT /locus_tag="Mb3257" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3257, -, len: 330 aa. Equivalent to Rv3228, len: FT 330 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 330 aa overlap). Conserved hypothetical FT protein, equivalent to Q9CCI4|ML0791 HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (327 aa), FASTA scores: opt: FT 1828, E(): 1e-98, (84.0% identity in 331 aa overlap). Also FT similar to several hypothetical bacterial proteins e.g. FT Q9K4A8|SC7E4.08c from Streptomyces coelicolor (337 aa), FT FASTA scores: opt: 1051, E(): 1e-53, (52.65% identity in FT 338 aa overlap); Q9HUL3|PA4952 from Pseudomonas aeruginosa FT (339 aa), FASTA scores: opt: 392 ,E(): 1.4e-15, (34.85% FT identity in 281 aa overlap); Q9PFV1|XF0556 from Xylella FT fastidiosa (341 aa), FASTA scores: opt: 367, E(): 4e-14, FT (36.85% identity in 247 aa overlap); FT P45339|YJEQ_HAEIN|HI1714 from Haemophilus influenzae (346 FT aa), FASTA scores: opt: 355, E(): 2e-13, (31.65% identity FT in 281 aa overlap); etc. Contains PS00017 ATP/GTP-binding FT site motif A." FT /db_xref="GOA:Q7TWY3" FT /db_xref="InterPro:IPR004881" FT /db_xref="UniProtKB/TrEMBL:Q7TWY3" FT /protein_id="CAD95349.1" FT /translation="MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRW FT GCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRR FT TADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLA FT PAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEAD FT RAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSD FT LAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT" FT CDS complement(117350..118633) FT /transl_table=11 FT /gene="Mb3258c" FT /locus_tag="Mb3258c" FT /product="POSSIBLE LINOLEOYL-COA DESATURASE FT (DELTA(6)-DESATURASE)" FT /EC_number="1.14.19.3" FT /note="Mb3258c, -, len: 427 aa. Equivalent to Rv3229c, len: FT 427 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 427 aa overlap). Possible linoleoyl-CoA FT desaturase (EC 1.14.19.3), showing similarity with FT desaturases and other proteins e.g. Q08871|DES6|SLL0262 FT LINOLEOYL-COA DESATURASE from Synechocystis sp. strain PCC FT 6803 (359 aa), FASTA scores: opt: 319, E(): 4e-13, (25.1% FT identity in 295 aa overlap); Q54795|DESD DELTA 6 DESATURASE FT from Spirulina platensis (368 aa), FASTA scores: opt: 268, FT E(): 7.7e-10, (25.0% identity in 300 aa overlap); FT Q9ZTU8|S276 PROTEIN WITH SIMILARITY TO CYTOCHROME B5 DOMAIN FT from Triticum aestivum (Wheat) (469 aa), FASTA scores: opt: FT 240, E(): 5.9e-08, (27.05% identity in 266 aa overlap); FT etc. Note that previously known as desA3." FT /db_xref="GOA:Q7TWY2" FT /db_xref="InterPro:IPR005804" FT /db_xref="UniProtKB/TrEMBL:Q7TWY2" FT /protein_id="CAD95350.1" FT /translation="MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRR FT TIAAQRALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWMNDPE FT IHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVTRDQRWKRYNIFNV FT VWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTRLREFSAKAGRQVFKDYVAFPAL FT TSLSPGATYRSTLTANVVANVIRNVWSNAVIFCGHFPDGAEKFTKTDMIGEPKGQWYLR FT QMLGSANFNAGPALRFMSGNLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTG FT SFLVQYGKTWRTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGL FT KTAIAAVRGRRRSKRMAKSVTEPDDLAA" FT CDS complement(118711..119853) FT /transl_table=11 FT /gene="Mb3259c" FT /locus_tag="Mb3259c" FT /product="HYPOTHETICAL OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb3259c, -, len: 380 aa. Equivalent to Rv3230c, len: FT 380 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 380 aa overlap). Putative oxidoreductase FT (EC 1.-.-.-), with some similarity to various proteins, FT especially reductases e.g. Q9HUS4|PA4889 PROBABLE FT OXIDOREDUCTASE from Pseudomonas aeruginosa (366 aa), FASTA FT scores: opt: 516, E(): 1.8e-24, (33.8% identity in 367 aa FT overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN from FT Pseudomonas putida (337 aa), FASTA scores: opt: 380, E(): FT 4e-16, (30.7% identity in 277 aa overlap); BAB34381|ECS0958 FT NADH OXIDOREDUCTASE FOR THE HCP from Escherichia coli FT strain O157:H7 (322 aa), FASTA scores: opt: 369, E(): FT 1.8e-15, (28.65% identity in 328 aa overlap); Q44253|ATDA5 FT ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter FT sp. (336 aa), FASTA scores: opt: 305, E(): 1.6e-11, (27.4% FT identity in 303 aa overlap); etc." FT /db_xref="GOA:Q7TWY1" FT /db_xref="HSSP:1FRR" FT /db_xref="InterPro:IPR017927" FT /db_xref="UniProtKB/TrEMBL:Q7TWY1" FT /protein_id="CAD95351.1" FT /translation="MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLP FT DDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDG FT CWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVL FT PDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAA FT DHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDR FT LHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQS FT CVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI" FT CDS complement(119963..120472) FT /transl_table=11 FT /gene="Mb3260c" FT /locus_tag="Mb3260c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3260c, -, len: 169 aa. Equivalent to Rv3231c, len: FT 169 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 169 aa overlap). Hypothetical protein, FT only similar to Q9KYX9|SCE33.03c HYPOTHETICAL 17.4 KDA FT PROTEIN from Streptomyces coelicolor (167 aa), FASTA FT scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWY0" FT /protein_id="CAD95352.1" FT /translation="MTQVYIPATLAMLQRLVADGALWPVNGTAFAVTPTLRESYAEGDD FT EELAEVALREAALASLRLLAADIGATADALPPRRAVLAAEVDDATYRPDLDDAVVRLAG FT PITIDQVVAAYVDNAGAEPAVMAAIAVIDAADLGDEDAELVVGDAQDHDLAWYANQELP FT FLLDLL" FT CDS complement(120469..121356) FT /transl_table=11 FT /gene="pvdS" FT /locus_tag="Mb3261c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN PVDS FT (PROBABLE RNA POLYMERASE SIGMA FACTOR)" FT /note="Mb3261c, pvdS, len: 295 aa. Equivalent to Rv3232c, FT len: 295 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 295 aa overlap). Possible pvdS, an FT alternative RNA polymerase sigma factor, highly similar FT (but N-terminus longer 25-50 residues approximatively) to FT Q9RIZ9|SCJ1.15 PUTATIVE REGULATOR from Streptomyces FT coelicolor (267 aa), FASTA scores: opt: 1189, E(): 1.4e-70, FT (65.65% identity in 262 aa overlap); Q9KU02|VC0728 FT HYPOTHETICAL PROTEIN from Vibrio cholerae (258 aa), FASTA FT scores: opt: 1074, E(): 4.5e-63, (62.6% identity in 254 aa FT overlap); P72119|PVDS PAO SUBSTRAIN OT684 PYOVERDINE GENE FT TRANSCRIPTIONAL REGULATOR PVDS (FRAGMENT) from Pseudomonas FT aeruginosa (see citation below) (237 aa), FASTA scores: FT opt: 988, E(): 1.8e-57, (60.8% identity in 227 aa overlap). FT Also highly similar to Q9I154|PA2428 HYPOTHETICAL PROTEIN FT from Pseudomonas aeruginosa (304 aa), FASTA scores: opt: FT 1057, E(): 6.8e-62, (60.7% identity in 252 aa overlap); FT Q9I6Z1|PA0141 HYPOTHETICAL PROTEIN from Pseudomonas FT aeruginosa (298 aa), FASTA scores: opt: 990, E(): 1.6e-57, FT (54.6% identity in 249 aa overlap); and other hypothetical FT bacterial proteins. Could be a member of a subfamily of RNA FT polymerase sigma factors which direct the synthesis of FT extracellular products by bacteria. Start uncertain." FT /db_xref="InterPro:IPR005660" FT /db_xref="UniProtKB/TrEMBL:Q7TWX9" FT /protein_id="CAD95353.1" FT /translation="MDIPSVDVSTATNDGASSRAKGHRSAAPGRRKISDAVYQAELFRL FT QTEFVKLQEWARHSGARLVVIFEGRDGAGKGGAIKRITEYLNPRVARIAALPAPTDRER FT GQWYYQRYIAHLPAKGEIVLFDRSWYNRAGVEKVMGFCTPQEYVLFLRQTPIFEQMLID FT DGILLRKYWFSVSDAEQLRRFKARRNDPVRQWKLSPMDLESVYRWEDYSRAKDEMMVHT FT DTPVSPWYVVESDIKKHARLNMMAHLLSTIDYADVEKPKVKLPPRPLVSGNYRRPPREL FT STYVDDYVATLIAR" FT CDS complement(121380..122789) FT /transl_table=11 FT /gene="Mb3262c" FT /locus_tag="Mb3262c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3262c, -, len: 469 aa. Equivalent to Rv3234c and FT Rv3233c, len: 271 aa and 196 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 266 aa FT overlap and 100.0% identity in 196 aa overlap). Rv3234c: FT Hypothetical protein, similar to C-terminus of FT Mycobacterium tuberculosis hypothetical proteins e.g. FT P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa), FASTA FT scores: opt: 498, E(): 5.2e-24, (36.8% identity in 261 aa FT overlap); MTCY03A2.28; MTCY31.23; MTCY493_29; MTCY28_26; FT MTV013_8; MTY13E12_33; etc. Also similar to FT Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from FT Mycobacterium leprae (491 aa), FASTA scores: opt: 309, E(): FT 4.3e-12, (33.35% identity in 189 aa overlap). Rv3233c: FT Hypothetical protein, similar to C-terminus of FT Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from FT Streptomyces coelicolor (446 aa), FASTA scores: opt: 308, FT E(): 1.2e-12, (32.0% identity in 200 aa overlap); and FT several hypothetical Mycobacterium tuberculosis proteins FT e.g. O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497 aa), FT FASTA scores: opt: 248, E(): 9.8e-09, (27.5% identity in FT 200 aa overlap); MTCY28_26; MTCY493_29; MTCY31_25; FT MTCY31_25. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. FT In Mycobacterium bovis, a single base insertion (*-g) leads FT to a single product that is more similar to Rv3234c." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/TrEMBL:Q7TWX8" FT /protein_id="CAD95354.1" FT /translation="MVTRLSASDASFYQLENTATPMYVGLLLILRRPRAGLSYEALLET FT VEQRLPQIPRYRQKVQEVKLGLARPVWIDDRDFDITYHVRRSALPSPGSDEQLHELIAR FT LAARPLDKSRPLWEMYLVEGLEKNRIALYTKSHQALINGVTALAIGHVIADRTRRPPAF FT PEDIWVPERDPGTTRLLLRAVGDWLVRPGAQLQAVGSAVAGLVTNSGQLVETGRKVLDI FT ARTVARGTAPSSPLNATVSRNRRFTVARASLDDYRTVRARYDCDVHDVVLTVIAGALGN FT WLMSRGEAVAPTATVRAMAPLSVYADDQLDSTGPGQAISQVTPFLVDLPVGEGNAVVRL FT SQIAHATESNPTAASLVDARTIVTLSGLAPATLHAMGVRVATSFSARLFNLLITNAPGT FT QSQMYIAGTKLLETYSVPPLLHNQALAISVTSYNGMLYFGINADRDAMSDVDLLPGLLS FT QALDELLEASR" FT CDS 122900..123541 FT /transl_table=11 FT /gene="Mb3263" FT /locus_tag="Mb3263" FT /product="HYPOTHETICAL ALANINE ARGININE PROLINE RICH FT PROTEIN" FT /note="Mb3263, -, len: 213 aa. Equivalent to Rv3235, len: FT 213 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 213 aa overlap). Hypothetical unknown FT ala-, arg-, pro-rich protein." FT /db_xref="UniProtKB/TrEMBL:Q7TWX7" FT /protein_id="CAD95355.1" FT /translation="MMASNQTAAQHSSATLQQAPRSIDDAGGCPLTISPIANSPGDTFA FT VTPVVEYEPPPRNIPPCGQSSHAARRPHTPQLARRQPIRPSGRAPAAVTSTAKSPRLRQ FT AGTFADAALRRVLEVIDRRRPVGQLRPLLAPGLVDSVLAVSRTAAGHQQGAAMLRRIRL FT TPAGPDTADTAAEVFGTYSRGDRIHAIACRVEQRPAGNETRWLMVALHIG" FT CDS complement(123559..124716) FT /transl_table=11 FT /gene="Mb3264c" FT /locus_tag="Mb3264c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT FT PROTEIN" FT /note="Mb3264c, -, len: 385 aa. Equivalent to Rv3236c, len: FT 385 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 385 aa overlap). Probable conserved FT integral membrane transport protein, possibly cation (Na/H) FT transporter, equivalent to Q9CCI5|ML0782 putative FT transmembrane transport protein from Mycobacterium leprae FT (385 aa), FASTA scores: opt: 1975, E(): 2.4e-108, (81.55% FT identity in 385 aa overlap). Highly similar to others e.g. FT O69958|SC4H2.03c putative transmembrane transport protein FT from Streptomyces coelicolor (411 aa), FASTA scores: opt: FT 1226, E(): 1.6e-64, (53.5% identity in 372 aa overlap); FT Q9XAKO|SC66T3.13c putative transmembrane transport protein FT from Streptomyces coelicolor (403 aa), FASTA scores: opt: FT 1198, E(): 6.8e-63, (53.25% identity in 370 aa overlap); FT Q9RV80|DR1149 putative Na+/H+ antiporter from Deinococcus FT radiodurans (383 aa), FASTA scores: opt: 1069, E(): FT 2.3e-55, (47.35% identity in 376 aa overlap); FT Q9L191|SC10G8.11 putative transmembrane transport protein FT from Streptomyces coelicolor (446 aa), FASTA scores: opt: FT 695, E(): 1.9e-33, (38.05% identity in 384 aa overlap); FT Q9RRW8|DR2367 putative glutathione-regulated FT potassium-efflux system protein KEFB from Deinococcus FT radiodurans (575 aa), FASTA scores: opt: 414, E(): 6.2e-17, FT (30.25% identity in 380 aa overlap); etc. SEEMS TO BELONG FT TO THE CPA2 FAMILY. Note that previously known as kefB." FT /db_xref="GOA:Q7TWX6" FT /db_xref="InterPro:IPR006153" FT /db_xref="UniProtKB/TrEMBL:Q7TWX6" FT /protein_id="CAD95356.1" FT /translation="MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLGN FT GGILGVAAAGEFIATGAPIGVVLLLLALGLEFSATEFASSLRHHLPSAGVDIVLNATPG FT AVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMA FT AYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVTHPDSEQLLLRV FT LGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRARMVLTPLRDLFATIFFLGIGLS FT VDPGKLVSMLPVALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARGEFSLII FT IGLAGASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN" FT CDS complement(124721..125203) FT /transl_table=11 FT /gene="Mb3265c" FT /locus_tag="Mb3265c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3265c, -, len: 160 aa. Equivalent to Rv3237c, len: FT 160 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 160 aa overlap). Conserved hypothetical FT protein, equivalent to Q9CCI6|ML0781 HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (160 aa), FASTA scores: opt: 828, FT E(): 1.5e-45, (80.6% identity in 160 aa overlap); and FT similar to other hypothetical bacterial proteins and more FT weakly to putative potassium channels e.g. Q9RV81|DR1148 FT CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans FT (175 aa), FASTA scores: opt: 420, E(): 9.5e-20, (37.95% FT identity in 158 aa overlap); O69959|SC4H2.04c HYPOTHETICAL FT 17.1 KDA PROTEIN from Streptomyces coelicolor (161 aa), FT FASTA scores: opt: 315, E(): 3.8e-13, (40.0% identity in FT 150 aa overlap); Q9HNH3|PCHB|VNG2104G POTASSIUM CHANNEL FT HOMOLOG from Halobacterium sp. strain NRC-1 (418 aa), FASTA FT scores: opt: 158, E(): 0.007, (31.45% identity in 124 aa FT overlap); Q58752|YD57_METJA|MJ1357 PUTATIVE POTASSIUM FT CHANNEL PROTEIN from Methanococcus jannaschii (343 aa), FT FASTA scores: opt: 143, E(): 0.053, (33.8% identity in 68 FT aa overlap)." FT /db_xref="GOA:Q7TWX5" FT /db_xref="InterPro:IPR006037" FT /db_xref="UniProtKB/TrEMBL:Q7TWX5" FT /protein_id="CAD95357.1" FT /translation="MDVKEVLLPGVGLRYEFTSYRGDRIGIVARRSGGFDVVLYGRDDP FT DEARPVLRLTDEEAEAVAQILGAPRIAERFTELTREVPGLKAGQIHIRAGSLFVDRPLG FT DTRARTRTGASIVAIVRDEDVLASPGPTDVLRAGDVLIVIGTEDGIAGVEQIVEKG" FT CDS complement(125264..125998) FT /transl_table=11 FT /gene="Mb3266c" FT /locus_tag="Mb3266c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb3266c, -, len: 244 aa. Equivalent to Rv3238c, len: FT 244 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 244 aa overlap). Probable conserved FT integral membrane protein, similar to several hypothetical FT proteins and transmembrane proteins e.g. Q9UN92|NRM29 FT MULTISPANNING NUCLEAR ENVELOPE MEMBRANE PROTEIN NURIM FT (FRAGMENT) from Homo sapiens (Human) (261 aa), FASTA FT scores: opt: 281, E(): 3.3e-11, (30.7% identity in 189 aa FT overlap); Q9VEG9|CG7655 HYPOTHETICAL PROTEIN from FT Drosophila melanogaster (Fruit fly) (253 aa), FASTA scores: FT opt: 242, E(): 1.1e-08, (27.7% identity in 242 aa overlap); FT BAB48937|MLR1600 HYPOTHETICAL PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (222 aa), FASTA scores: opt: 137, E(): FT 0.066, (28.1% identity in 185 aa overlap); BAB57936|SAV1774 FT AESENICAL PUMP MEMBRANE PROTEIN HOMOLOG from Staphylococcus FT aureus subsp. aureus Mu50 (430 aa), FASTA scores: opt: 125, FT E(): 0.68, (25.7% identity in 144 aa overlap); etc." FT /db_xref="UniProtKB/TrEMBL:Q7TWX4" FT /protein_id="CAD95358.1" FT /translation="MKRYLTIIYGAASYLVFLVAFGYAIGFVGDVVVPRTVDHAIAAPI FT GQAVVVNLVLLGVFAVQHSVMARQGFKRWWTRFVPPSIERSTYVLLASVALLLLYWQWR FT TMPAVIWDVRQPAGRVALWALFWLGWATVLTSTFMINHFELFGLRQVYLAWRGKPYTEI FT GFQAHLLYRWVRHPIMLGFVVAFWATPMMTAGHLLFAIGATGYILVALQFEERDLLAAL FT GDQYRDYRREVSMLLPWPHRHT" FT CDS complement(126057..129203) FT /transl_table=11 FT /gene="Mb3267c" FT /locus_tag="Mb3267c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN" FT /note="Mb3267c, -, len: 1048 aa. Equivalent to Rv3239c, FT len: 1048 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1048 aa overlap). Probable conserved FT transmembrane protein, organised in two domains. Domain FT comprising first ~500 aa residues is similar to various FT antibiotic resistance and efflux proteins and contains FT sugar transport proteins signature 1 (PS00216); e.g. FT Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from FT Streptomyces coelicolor (489 aa), FASTA scores: opt: 905, FT E(): 3.1e-41, (36.95% identity in 482 aa overlap); and FT O68912|FRNF PUTATIVE ANTIBIOTIC ANTIPORTER from FT Streptomyces roseofulvus (517 aa), FASTA scores: opt: 866, FT E(): 4.1e-39, (37.1% identity in 512 aa overlap). Second FT part, corresponding to last 550 aa residues, is very FT similar to Q50733|Rv2565|MTCY9C4.03c hypothetical 62.1 kd FT protein from Mycobacterium tuberculosis (583 aa), FASTA FT scores: E(): 2.1e-28, (36.5% identity in 572 aa overlap). FT Also equivalent to Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN FT MEMBRANE PROTEIN (SIMILAR TO SUGAR TRANSPORTER FAMILY) from FT Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: FT 4328, E(): 0, (64.15% identity in 1046 aa overlap); and FT similar to other Mycobacterium tuberculosis proteins: FT MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E(): 6.3e-32; FT MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E(): 2.5e-26. FT Equivalent to AAK47679 Drug transporter from Mycobacterium FT tuberculosis strain CDC1551 (1065 aa) but shorter 20 aa. FT Contains cyclic nucleotide-binding domain signature 2 FT (PS00889). Probably member of major facilitator superfamily FT (MFS)." FT /db_xref="GOA:Q7TWX3" FT /db_xref="InterPro:IPR018488" FT /db_xref="UniProtKB/TrEMBL:Q7TWX3" FT /protein_id="CAD95359.1" FT /translation="MHISLHGGKGFANLTRRRRPSSASVLLVAGFGAFLAFLDSTIVNI FT AFPDIQRSFPSYDIGSLSWILNGYNIVFAAFMVAAGRLADLLGRRRTFLSGVLVFTIAS FT GLCAVAGSVEQLVAFRVLQGIGAAILVPASLALVVEGFDAARRAHAIGLWGAAAAIAAG FT LGPPIGGLLVEWAGWRWVLLVNVPLGIVAAIATKRMLVESRASGRRRMPDLRGALLLAV FT TLGLVTLGLVKGPDWGWLSVATVGSFLASVLTSVGFVHSSRSHPAPLVEPALLRSRSFV FT AGNLLTLVAAAGFYCYGLTHVLYLNYVWHYSLLKAGFAIAPAAVVAAVVAAALGRVAGR FT HGHRVIVLVGALVWAGSLVWYLQRVGSEPDFLRVWLPGQLLQGIGVGATLPVLSSAALA FT EVAKGGSYATSSAVVSTTRQLGAVLGVAVMVILIGKPEHGTAEEALRRGWAMAAICFIA FT VAVAAAVLGRTNRNPVQMPAPEPAIAPRLEPPIPQPAAAPIEHWAAGDADPLGNLPLFA FT GLDAATLAQLGEHVEDVELEAGCYLFHEGDPSDSLYVIRTGRVQVLQDSIVLKELGRGE FT VLGELGLLIDAPRSATVRALRDTKLVRLTKAQFDEIADHGALAALVKVLATRLREAPPP FT ATDSTSPEVVVSVIGVSGDAPVPAVAAGLLTALSARLRAVDPGRVDRDGLDRAERVADK FT VVLHAAVEDAGWRDFCLRVADRIVLVAGDPNPQAARLPARARGADLVLAGPAASREHRR FT QWEELITPRSVHVVHYRRILENVRPLAARIAGRSIGLVLGGGGARGFAHLGVLDELERV FT GVTIDRFAGTSMGAVIAVFGACGMDAATADAYAYEYFIRHNPLSDYAFPVRGLVHGRRT FT LTLLEAAFGDRLVEELPKEFRCVSVDLLARRPVVHRRGRLVDVIGCSLRLPGIYPPQVY FT NGRLHVDGGVLDNLPVSTRASPDGPLIAVSIGLGGGGPGSARQDGSPKVPGIGDTLMRT FT MTIGSQRGADAALSLAQVVIRPDTGAVGLLEFHQIDAAREAGRVAAREAMPHIMALLNR FT " FT CDS complement(129282..132131) FT /transl_table=11 FT /gene="secA1" FT /locus_tag="Mb3268c" FT /standard_name="secA" FT /product="PROBABLE PREPROTEIN TRANSLOCASE SECA1 1 SUBUNIT" FT /note="Mb3268c, secA1, len: 949 aa. Equivalent to Rv3240c, FT len: 949 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 949 aa overlap). Probable secA1, FT preprotein translocase subunit, component of secretion FT apparatus, highly similar to many e.g. P57996|SEA1_MYCLE FT from Mycobacterium leprae (940 aa), FASTA scores: opt: FT 5044, E(): 0, (87.5% identity in 849 aa overlap); FT P95759|SECA_STRGR from Streptomyces griseus (940 aa), FASTA FT scores: opt: 2612, E(): 1.9e-134, (61.35% identity in 960 FT aa overlap); P28366|SECA_BACSU|DIV+ from Bacillus subtilis FT (841 aa), FASTA scores: opt: 1776, E(): 4.9e-89, (48.05% FT identity in 837 aa overlap); etc. BELONGS TO THE SECA FT FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION FT APPARATUS WHICH COMPRISE SECA, SECD|Rv2587c, SECE|Rv0638, FT SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. Note that FT previously known as secA." FT /db_xref="GOA:P0A5Y9" FT /db_xref="InterPro:IPR011116" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Y9" FT /protein_id="CAD95360.1" FT /translation="MLSKLLRLGEGRMVKRLKKVADYVGTLSDDVEKLTDAELRAKTDE FT FKRRLADQKNPETLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGAAALHLGNVAEMKTG FT EGKTLTCVLPAYLNALAGNGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILATMTPD FT ERRVAYNADITYGTNNEFGFDYLRDNMAHSLDDLVQRGHHYAIVDEVDSILIDEARTPL FT IISGPADGASNWYTEFARLAPLMEKDVHYEVDLRKRTVGVHEKGVEFVEDQLGIDNLYE FT AANSPLVSYLNNALKAKELFSRDKDYIVRDGEVLIVDEFTGRVLIGRRYNEGMHQAIEA FT KEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVSIPTNMPM FT IREDQSDLIYKTEEAKYIAVVDDVAERYAKGQPVLIGTTSVERSEYLSRQFTKRRIPHN FT VLNAKYHEQEATIIAVAGRRGGVTVATNMAGRGTDIVLGGNVDFLTDQRLRERGLDPVE FT TPEEYEAAWHSELPIVKEEASKEAKEVIEAGGLYVLGTERHESRRIDNQLRGRSGRQGD FT PGESRFYLSLGDELMRRFNGAALETLLTRLNLPDDVPIEAKMVTRAIKSAQTQVEQQNF FT EVRKNVLKYDEVMNQQRKVIYAERRRILEGENLKDQALDMVRDVITAYVDGATGEGYAE FT DWDLDALWTALKTLYPVGITADSLTRKDHEFERDDLTREELLEALLKDAERAYAAREAE FT LEEIAGEGAMRQLERNVLLNVIDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGY FT DMFMAMLDGMKEESVGFLFNVTVEAVPAPPVAPAAEPAELAEFAAAAAAAAQQRSAVDG FT GARERAPSALRAKGVASESPALTYSGPAEDGSAQVQRNGGGAHKTPAGVPAGASRRERR FT EAARRQGRGAKPPKSVKKR" FT CDS complement(132210..132854) FT /transl_table=11 FT /gene="Mb3269c" FT /locus_tag="Mb3269c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3269c, -, len: 214 aa. Equivalent to Rv3241c, len: FT 214 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 214 aa overlap). Conserved hypothetical FT protein, similar to many hypothetical proteins and to some FT putative ribosomal proteins e.g. Q9CCI7|ML0778 HYPOTHETICAL FT PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: FT opt: 1234, E(): 1.3e-72, (89.3% identity in 206 aa FT overlap); Q9KYX2|SCE33.11c HYPOTHETICAL 27.9 KDA PROTEIN FT from Streptomyces coelicolor (254 aa), FASTA scores: opt: FT 487, E(): 2.2e-24, (47.6% identity in 210 aa overlap); FT Q9FLV3 PROTEIN SIMILAR TO RIBOSOMAL PROTEIN 30S SUBUNIT FT from Arabidopsis thaliana (Mouse-ear cress) (365 aa), FASTA FT scores: opt: 264, E(): 7e-10, (26.4% identity in 212 aa FT overlap); P19954|RR30_SPIOL|RPS22 PLASTID-SPECIFIC 30S FT RIBOSOMAL PROTEIN 1, chloroplast, from Spinacia oleracea FT (Spinach) (302 aa), FASTA scores: opt: 261, E(): 9.3e-10, FT (26.15% identity in 214 aa overlap); P47995|YSEA_STACA FT HYPOTHETICAL PROTEIN IN SECA 5'REGION (ORF1) (FRAGMENT) FT (BELONGS TO THE S30AE FAMILY OF RIBOSOMAL PROTEINS) from FT Staphylococcus carnosus (165 aa), FASTA scores: opt: 201, FT E(): 4.2e-06, (33.35% identity in 147 aa overlap); etc." FT /db_xref="GOA:Q7TWX2" FT /db_xref="InterPro:IPR003489" FT /db_xref="UniProtKB/TrEMBL:Q7TWX2" FT /protein_id="CAD95361.1" FT /translation="MDSGQVLAEPKSNAEIVFKGRNVEIPDHFRIYVSQKLARLERFDR FT TIYLFDVELDHERNRRQRKSCQRVEITARGRGPVVRGEACADSFYAALESAVVKLESRL FT RRGKDRRKVHYGDKTPVSLAEATAVVPAPENGFNTRPAEAHDHDGAVVEREPGRIVRTK FT EHPAKPMSVDDALYQMELVGHDFFLFYDKDTERPSVVYRRHAYDYGLIRLA" FT CDS complement(133170..133811) FT /transl_table=11 FT /gene="Mb3270c" FT /locus_tag="Mb3270c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3270c, -, len: 213 aa. Equivalent to Rv3242c, len: FT 213 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 213 aa overlap). Conserved hypothetical FT protein, highly similar in N-terminus to Q9CCI9|ML0776 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (85 aa), FT FASTA scores: opt: 324, E(): 1.7e-13, (78.1% identity in 64 FT aa overlap). Also similar to Q9RUJ7|DR1389 PUTATIVE FT COMPETENCE PROTEIN COMF from Deinococcus radiodurans (219 FT aa), FASTA scores: opt: 223, E(): 6.3e-07, (35.8% identity FT in 215 aa overlap); BAB50338|MLL3453 HYPOTHETICAL PROTEIN FT from Rhizobium loti (Mesorhizobium loti) (240 aa), FASTA FT scores: opt: 218, E(): 1.4e-06, (28.5% identity in 224 aa FT overlap); Q9A9Y1|CC0830 COMPETENCE PROTEIN F from FT Caulobacter crescentus (265 aa), FASTA scores: opt: 182, FT E(): 0.00026, (30.15% identity in 219 aa overlap); etc. FT Equivalent to AAK47682 from Mycobacterium tuberculosis FT strain CDC1551 (241 aa) but shorter 29 aa. Contains FT purine/pyrimidine phosphoribosyl transferases signature FT (PS00103). SEEMS TO BELONG TO PURINE/PYRIMIDINE FT PHOSPHORIBOSYL TRANSFERASE FAMILY." FT /db_xref="GOA:Q7TWX1" FT /db_xref="InterPro:IPR002375" FT /db_xref="UniProtKB/TrEMBL:Q7TWX1" FT /protein_id="CAD95362.1" FT /translation="MLDLVLPLECGGCGAPATRWCAACAAELSVAAGEPHVVSPRVDPQ FT VPVFALGRYAGVRRQAILAMKEHGRRDLVAPLACALIVGVDHLLSWGMLENPLTMVPAP FT TRRWAARRRGGDPVSRMARIAGATLGRHHDVTVVPALRMRALARDSVGLGASARERNIT FT GRVLLRGQRPRNEVVLVDDIITTGATARESVRVLQAAGVRVGAVLAVAAA" FT CDS complement(133849..134691) FT /transl_table=11 FT /gene="Mb3271c" FT /locus_tag="Mb3271c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb3271c, -, len: 280 aa. Equivalent to Rv3243c, len: FT 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 280 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TWX0" FT /protein_id="CAD95363.1" FT /translation="MSPRVPRLRWDDPFRALDMLASLWSSTGMSLVSAGAAQAVAAPYR FT TLFTTLQQLLIGKEVTVRIGDHDVVLTVTELDSALEPQGLAVGQLGEVRVAARGISWDQ FT HHLHSAVAVLRNVHIRPGVPPLVIAAPVELSSALPTEIFDDVLRQATPQLRGELSESGA FT ARLRWARRPDWGGLEVDVDVAGTTSQTTLWLRPRTVITGQRRWTLPARTPAYRVPLPEL FT PHGLRITDVSLAADCLQLSALLPEWRTELPLRYLESVITQLSQGALSFVWPPLRSGAD" FT CDS complement(134759..136510) FT /transl_table=11 FT /gene="lpqB" FT /locus_tag="Mb3272c" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPQB" FT /note="Mb3272c, lpqB, len: 583 aa. Equivalent to Rv3244c, FT len: 583 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 583 aa overlap). Probable lpqB, FT conserved lipoprotein; contains appropriately placed FT lipoprotein signature (PS00013). Equivalent to FT Q9CCJ0|LPQB|ML0775 PUTATIVE LIPOPROTEIN from Mycobacterium FT leprae (589 aa), FASTA scores: opt: 3375, E(): 1.4e-186, FT (87.9% identity in 579 aa overlap). Also similar to various FT proteins (in particular transferases) e.g. Q9KYX0|SCE33.13c FT PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (615 aa), FT FASTA scores: opt: 228, E(): 1.3e-05, (25.5% identity in FT 624 aa overlap); O87992|BBLPS1.19c PUTATIVE GLUTAMINE FT AMIDOTRANSFERASE from Bordetella bronchiseptica FT (Alcaligenes bronchisepticus) (628 aa), FASTA scores: opt: FT 162, E(): 0.079, (28.05% identity in 171 aa overlap); FT Q9L2F4|SC7A8.01 PUTATIVE SUGAR KINASE (FRAGMENT) from FT Streptomyces coelicolor (434 aa), FASTA scores: opt: 143, FT E(): 0.72, (27.65% identity in 293 aa overlap); etc." FT /db_xref="GOA:Q7TWW9" FT /db_xref="InterPro:IPR019606" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWW9" FT /protein_id="CAD95364.1" FT /translation="MRLTILLFLGAVLAGCASVPSTSAPQAIGTVERPVPSNLPKPSPG FT MDPDVLLREFLKATADPANRHLAARQFLTESASNAWDDAGSALLIDHVVFVETRSAEKV FT SVTMRADILGSLSDVGVFETAEGQLPDPGPIELVKTSGGWRIDRLPNGVFLDWQQFQET FT YKRNTLYFADPTGKTVVPDPRYVAVSDRDQLATELVSKLLAGPRPEMARTVRNLLAPPL FT RLRGPVTRADGGKSGIGRGYGGARVDMEKLSTTDPHSRQLLAAQIIWTLARADIRGPYV FT INADGAPLEDRFAEGWTTSDVAATDPGVADGAAAGLHALVNGSLVAMDAQRVTPVPGAF FT GRMPEQTAAAVSRSGRQVASVVTLGRGAPDEAASLWVGDLGGEAVQSADGHSLLRPSWS FT LDDAVWVVVDTNVVLRAIQDPASGQPARIPVDSTAVASRFPGAINDLQLSRDGTRAAMV FT IGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDAAHPVSYV FT NLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGWADVPGLMVPG FT AAPVLPG" FT CDS complement(136510..138213) FT /transl_table=11 FT /gene="mtrB" FT /locus_tag="Mb3273c" FT /product="TWO COMPONENT SENSORY TRANSDUCTION HISTIDINE FT KINASE MTRB" FT /EC_number="2.7.3.-" FT /note="Mb3273c, mtrB, len: 567 aa. Equivalent to Rv3245c, FT len: 567 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 567 aa overlap). mtrB, sensor-like FT histidine kinase (EC 2.7.3.-) (see citations below), FT equivalent to Q9CCJ1|MTRB OR ML0774 PUTATIVE TWO-COMPONENT FT SYSTEM SENSOR KINASE from Mycobacterium leprae (562 aa), FT FASTA scores: opt: 3208, E(): 7.4e-173, (88.7% identity in FT 566 aa overlap). Also similar to others e.g. FT Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM HISTIDINE FT KINASE from Streptomyces coelicolor (688 aa), FASTA scores: FT opt: 1355, E(): 1.1e-68, (48.95% identity in 515 aa FT overlap); etc. Relatives in Mycobacterium tuberculosis are: FT MTCY369.03, E(): 1.5e-22; MTCY20G9.16, E(): 1.9e-17. FT SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE FT KINASES." FT /db_xref="GOA:P59963" FT /db_xref="InterPro:IPR005467" FT /db_xref="UniProtKB/Swiss-Prot:P59963" FT /protein_id="CAD95365.1" FT /translation="MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVAL FT TLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSL FT QLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKAGQA FT AYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVL FT LVLLAGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAES FT LSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSADLDPTLRRSTELMV FT SELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDL FT PAEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPG FT EEKLVFSRFWRSDPSRVRRSGGTGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPL FT VRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPREHAEWSG" FT CDS complement(138263..138949) FT /transl_table=11 FT /gene="mtrA" FT /locus_tag="Mb3274c" FT /product="TWO COMPONENT SENSORY TRANSDUCTION FT TRANSCRIPTIONAL REGULATORY PROTEIN MTRA" FT /note="Mb3274c, mtrA, len: 228 aa. Equivalent to Rv3246c, FT len: 228 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 228 aa overlap). mtrA, transcriptional FT activator, response regulator (see citations below), FT equivalent to Q9CCJ2|MTRA|ML0773 PUTATIVE TWO-COMPONENT FT RESPONSE REGULATOR from Mycobacterium leprae (228 aa), FT FASTA scores: opt: 1458, E(): 1.4e-85, (98.7% identity in FT 228 aa overlap). Also highly similar to others e.g. FT Q9F9J5|SCRA PUTATIVE RESPONSE REGULATOR from Streptomyces FT coelicolor (228 aa), FASTA scores: opt: 1141, E(): 1.9e-65, FT (74.9% identity in 227 aa overlap); Q9KYW8|SCE33.15c FT PUTATIVE TWO-COMPONENT SYSTEM RESPONSE REGULATOR from FT Streptomyces coelicolor (229 aa), FASTA scores: opt: 1141, FT E(): 1.9e-65, (74.9% identity in 227 aa overlap); FT Q9F868|REGX3 RESPONSE REGULATOR REGX3 from Mycobacterium FT smegmatis (228 aa), FASTA scores: opt: 730, E(): 2.3e-39, FT (50.90% identity in 222 aa overlap); etc. Relatives in FT Mycobacterium tuberculosis are: U01971|MTU01971_1; FT Q11156|RGX3_MYCTU; MTCY20G9.17, E(): 0; MTCY31.31c, E(): FT 3.4e-29; MTCY369.02, E(): 5.7e-28. SIMILAR TO BACTERIAL FT REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. THE FT N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY FT COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Experiments FT showed mtrA is differentially expressed in virulent and FT avirulent strains during growth in macrophages." FT /db_xref="GOA:P0A5Z5" FT /db_xref="HSSP:1B00" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Z5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95366.1" FT /translation="MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAV FT RELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIM FT KPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLV FT ALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG FT YKAGPP" FT CDS complement(139019..139663) FT /transl_table=11 FT /gene="tmk" FT /locus_tag="Mb3275c" FT /product="PROBABLE THYMIDYLATE KINASE TMK (dTMP KINASE) FT (THYMIDYLIC ACID KINASE) (TMPK)" FT /EC_number="2.7.4.9" FT /note="Mb3275c, tmk, len: 214 aa. Equivalent to Rv3247c, FT len: 214 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 214 aa overlap). Probable tmk, FT thymidylate kinase (EC 2.7.4.9), equivalent to FT Q9CCJ3|TMK|ML0772 PUTATIVE THYMIDYLATE KINASE from FT Mycobacterium leprae (210 aa), FASTA scores: opt: 1023, FT E(): 4.8e-57, (77.3% identity in 207 aa overlap). Also FT similar to other thymidylate kinases e.g. FT Q9RQJ9|KTHY_CAUCR|TMK|CC1824 from Caulobacter crescentus FT (208 aa), FASTA scores: opt: 179, E(): 0.0003, (31.3% FT identity in 214 aa overlap); Q9V1E9|KTHY_PYRAB|TMK|PAB0319 FT from Pyrococcus abyssi (205 aa), FASTA scores: opt: 176, FT E(): 0.00045, (29.1% identity in 189 aa overlap); etc. FT BELONGS TO THE THYMIDYLATE KINASE FAMILY." FT /db_xref="GOA:Q7TWW8" FT /db_xref="HSSP:1GTV" FT /db_xref="InterPro:IPR018095" FT /db_xref="UniProtKB/TrEMBL:Q7TWW8" FT /protein_id="CAD95367.1" FT /translation="MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAA FT DIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYS FT AARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARD FT NYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS" FT CDS complement(139760..141247) FT /transl_table=11 FT /gene="sahH" FT /locus_tag="Mb3276c" FT /product="PROBABLE ADENOSYLHOMOCYSTEINASE SAHH FT (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE)" FT /EC_number="3.3.1.1" FT /note="Mb3276c, sahH, len: 495 aa. Equivalent to Rv3248c, FT len: 495 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 495 aa overlap). Probable sahH, FT adenosylhomocysteinase (EC 3.3.1.1), equivalent to FT Q9CCJ4|SAHH|ML0771 PUTATIVE S-ADENOSYL-L-HOMOCYSTEINE FT HYDROLASE from Mycobacterium leprae (492 aa), FASTA scores: FT opt: 3019, E(): 1.3e-177, (91.4% identity in 489 aa FT overlap). Also highly similar to other FT adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces FT coelicolor (485 aa), FASTA scores: opt: 2258, E(): FT 5.7e-131, (70.0% identity in 483 aa overlap); FT P51540|SAHH_TRIVA from Trichomonas vaginalis (486 aa), FT FASTA scores: opt: 2005, E(): 1.8e-115, (62.05% identity in FT 477 aa overlap); P35007|SAHH_CATRO from Catharanthus roseus FT (Rosy periwinkle) (Madagascar periwinkle) (485 aa), FASTA FT scores: opt: 1941, E(): 1.5e-111, (60.15% identity in 492 FT aa overlap); etc. Has S-adenosyl-L-homocysteine hydrolase FT signature (PS00739). BELONGS TO THE ADENOSYLHOMOCYSTEINASE FT FAMILY." FT /db_xref="GOA:Q7TWW7" FT /db_xref="InterPro:IPR020082" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWW7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95368.1" FT /translation="MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPG FT LMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAA FT AVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATML FT VLRGMQYEKAGVVPPAEEDDPAEWKIFLNLLRTRFETDKDKWTKIAESVKGVTEETTTG FT VLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLIC FT GYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGN FT KDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSI FT IVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVA FT RIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY" FT CDS complement(141352..141987) FT /transl_table=11 FT /gene="Mb3277c" FT /locus_tag="Mb3277c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /note="Mb3277c, -, len: 211 aa. Equivalent to Rv3249c, len: FT 211 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 211 aa overlap). Possible FT transcriptional regulatory protein, tetR family, with FT similarity to several e.g. Q9AE61|ALKB1 PUTATIVE FT TETR-REGULATORY from Rhodococcus erythropolis (208 aa), FT FASTA scores: opt: 503, E(): 7.7e-26, (40.6% identity in FT 192 aa overlap); CAC37620 PUTATIVE TETR-REGULATORY PROTEIN FT from Prauserella rugosa (212 aa), FASTA scores: opt: 246, FT E(): 4.4e-09, (27.95% identity in 186 aa overlap); FT Q9K4B0|SC7E4.06 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from FT Streptomyces coelicolor (203 aa), FASTA scores: opt: 224, FT E(): 1.1e-07, (34.5% identity in 197 aa overlap); FT Q11063|YC55_MYCTU|Rv1255c|MT1294|MTCY50.27 HYPOTHETICAL FT TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis FT (202 aa), FASTA scores: opt: 191, E(): 1.6e-05, (28.35% FT identity in 180 aa overlap); etc. Equivalent to AAK47689 FT from Mycobacterium tuberculosis strain CDC1551 (230 aa) but FT shorter 19 aa. COULD BELONG TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS. Possible helix-turn helix motif FT at aa 44-65 (+6.66 SD)." FT /db_xref="GOA:Q7TWW6" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7TWW6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95369.1" FT /translation="MSTPSATVAPVKRIPYAEASRALLRDSVLDAMRDLLLTRDWSAIT FT LSDVARAAGISRQTIYNEFGSRQGLAQGYALRLADRLVDNVHASLDANVGNFYEAFLQG FT FRSFFAESAADPLVISLLTGVAKPDLLQLITTDSAPIITRASARLAPAFTDTWVATTDN FT DANVLSRAIVRLCLSYVSMPPEADHDVAADLARLITPFAERHGVINVP" FT CDS complement(141984..142166) FT /transl_table=11 FT /gene="rubB" FT /locus_tag="Mb3278c" FT /product="PROBABLE RUBREDOXIN RUBB" FT /note="Mb3278c, -, len: 60 aa. Equivalent to Rv3250c, len: FT 60 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 60 aa overlap). Probable rubB, FT rubredoxin, highly similar to other rubredoxins e.g. FT Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa), FASTA FT scores: opt: 391, E(): 2.2e-21, (83.05% identity in 59 aa FT overlap); Q9AE63|RUBA2 from Rhodococcus erythropolis (63 FT aa), FASTA scores: opt: 380, E(): 1.4e-20, (83.9% identity FT in 56 aa overlap); P42453|RUBR_ACICA|RUBA from FT Acinetobacter calcoaceticus (54 aa), FASTA scores: opt: FT 315, E(): 4.9e-16, (69.8% identity in 53 aa overlap); FT Q9HTK7|PA5351 from Pseudomonas aeruginosa (55 aa), FASTA FT scores: opt: 298, E(): 8e-15, (64.15% identity in 53 aa FT overlap); Q9PGC3|XF0379 from Xylella fastidiosa (57 aa), FT FASTA scores: opt: 263, E(): 2.5e-12, (59.25% identity in FT 54 aa overlap); etc. Also similar to neighbouring ORF M. FT tuberculosis RubA (MTCY20B11.26c). Contains rubredoxin FT signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY." FT /db_xref="GOA:Q7TWW5" FT /db_xref="HSSP:1E8J" FT /db_xref="InterPro:IPR018527" FT /db_xref="UniProtKB/TrEMBL:Q7TWW5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95370.1" FT /translation="MNDYKLFRCIQCGFEYDEALGWPEDGIAAGTRWDDIPDDWSCPDC FT GAAKSDFEMVEVARS" FT CDS complement(142171..142338) FT /transl_table=11 FT /gene="rubA" FT /locus_tag="Mb3279c" FT /product="PROBABLE RUBREDOXIN RUBA" FT /note="Mb3279c, -, len: 55 aa. Equivalent to Rv3251c, len: FT 55 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 55 aa overlap). Probable rubA, FT rubredoxin, highly similar to other rubredoxins (but FT sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus FT erythropolis (61 aa), FASTA scores: opt: 335, E(): 1e-17, FT (73.6% identity in 53 aa overlap); P00272|RUB2_PSEOL|ALKG FT from Pseudomonas oleovorans (172 aa), FASTA scores: opt: FT 278, E(): 2.7e-13, (65.3% identity in 49 aa overlap); FT CAC38028|ALKG from Alcanivorax borkumensis (174 aa), FASTA FT scores: opt: 271, E(): 8.6e-13, (62.0% identity in 50 aa FT overlap); Q9WWW4|ALKG from Pseudomonas putida (175 aa), FT FASTA scores: opt: 270, E(): 1e-12, (61.8% identity in 55 FT aa overlap); etc. Also highly similar to C-terminus of FT Q9XBM1|ALKB ALKANE 1-MONOOXYGENASE (EC 1.14.15.3) from FT Prauserella rugosa (490 aa), FASTA scores: opt: 296, E(): FT 2.9e-14, (75.5% identity in 49 aa overlap). Also similar to FT neighbouring ORF Mycobacterium tuberculosis rubB FT (MTCY20B11.25c). Contains rubredoxin signature (PS00202). FT BELONGS TO THE RUBREDOXIN FAMILY." FT /db_xref="GOA:Q7TWW4" FT /db_xref="HSSP:1RWD" FT /db_xref="InterPro:IPR018527" FT /db_xref="UniProtKB/TrEMBL:Q7TWW4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95371.1" FT /translation="MAAYRCPVCDYVYDEANGDAREGFPAGTGWDQIPDDWCCPDCAVR FT EKVDFEKIGG" FT CDS complement(142338..143588) FT /transl_table=11 FT /gene="alkB" FT /locus_tag="Mb3280c" FT /product="PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE FT ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) FT (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE FT HYDROXYLASE-RUBREDOXIN)" FT /EC_number="1.14.15.3" FT /note="Mb3280c, alkB, len: 416 aa. Equivalent to Rv3252c, FT len: 416 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 416 aa overlap). Probable alkB, FT transmembrane alkane-1-monooxygenase (EC 1.14.15.3), highly FT similar to many e.g. Q9AE68|ALKB2 from Rhodococcus FT erythropolis (408 aa), FASTA scores: opt: 2018, E(): FT 9.6e-122, (68.6% identity in 415 aa overlap); Q9AFD5|ALKB FT from Nocardioides sp. CF8 (483 aa), FASTA scores: opt: FT 1485, E(): 1.4e-87, (56.55% identity in 405 aa overlap); FT Q9XAU0|ALKB1 from Rhodococcus erythropolis (391 aa), FASTA FT scores: opt: 1400, E(): 3.3e-82, (62.6% identity in 396 aa FT overlap); Q9XBM1|ALKB from Prauserella rugosa (490 aa), FT FASTA scores: opt: 1266, E(): 1.5e-73, (57.55% identity in FT 410 aa overlap); CAC40954|ALKB4 from Rhodococcus FT erythropolis (386 aa), FASTA scores: opt: 1190, E(): FT 9.1e-69, (54.3% identity in 383 aa overlap); etc." FT /db_xref="GOA:Q7TWW3" FT /db_xref="InterPro:IPR005804" FT /db_xref="UniProtKB/TrEMBL:Q7TWW3" FT /protein_id="CAD95372.1" FT /translation="MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLPL FT IWGMNQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDKYYRYC FT TYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSVGVLGGVGINTAHEM FT GHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRVSTPEDPASARFGETLWEFLPRSV FT IGGLRSAVHLEAQRLRRLGVSPWNPMTYLRNDVLNAWLMSVVLWGGLIAVFGPALIPFV FT IIQAVFGFSLLEAVNYLEHYGLLRQKSANGRYERCAPVHSWNSDHIVTNLFLYHLQRHS FT DHHANPTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDITRVN FT LHPRVREKALARYGASA" FT CDS complement(143697..145184) FT /transl_table=11 FT /gene="Mb3281c" FT /locus_tag="Mb3281c" FT /product="POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL FT MEMBRANE PROTEIN" FT /note="Mb3281c, -, len: 495 aa. Equivalent to Rv3253c, len: FT 495 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 495 aa overlap). Possible cationic FT amino acid transporter, integral membrane protein, similar FT to many e.g. O69844|SC1C3.02 PUTATIVE CATIONIC AMINO ACID FT TRANSPORTER from Streptomyces coelicolor (503 aa), FASTA FT scores: opt: 1649, E(): 5.8e-92, (52.6% identity in 485 aa FT overlap); Q9AE69 PUTATIVE TRANSPORTER (FRAGMENT) from FT Rhodococcus erythropolis (385 aa), FASTA scores: opt: 1594, FT E(): 9.7e-89, (62.0% identity in 387 aa overlap); FT Q9PBD7|XF2207 CATIONIC AMINO ACID TRANSPORTER from Xylella FT fastidiosa (483 aa), FASTA scores: opt: 1079, E(): 1.2e-57, FT (40.55% identity in 493 aa overlap); Q9SRU9|F20H23.25 FT PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Arabidopsis FT thaliana (Mouse-ear cress) (614 aa), FASTA scores: opt: FT 802, E(): 6.7e-41, (36.4% identity in 445 aa overlap); FT P30823|CTR1_RAT|SLC7A1|ATRC1 HIGH-AFFINITY CATIONIC AMINO FT ACID TRANSPORTER-1 from Rattus norvegicus (Rat) (624 aa), FT FASTA scores: opt: 782, E(): 1.1e-39, (36.1% identity in FT 432 aa overlap); etc. Relatives in Mycobacterium FT tuberculosis include: MTCY3G12.14, E(): 5.6e-31; MTCY39.19, FT E(): 1.6e-14. SEEMS TO BELONG TO THE APC FAMILY." FT /db_xref="GOA:Q7TWW2" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/TrEMBL:Q7TWW2" FT /protein_id="CAD95373.1" FT /translation="MAGRRRMKSVEQSIADTDEPTTRLRKDLTWWDLVVFGVSVVIGAG FT IFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVAGSAYTFSYATFGEF FT LAWVIGWNLVLELAMGAAVVAKGWSSYLGTVFGFGNGTGHLGSLQLDWGALVIVTLVAT FT LIALGTKLSSRFSAVVTAIKVSVVVLVVVVGAFYIRAANYSPFIPEPEVQHHGGGLDQS FT VFSLLTGAQGSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGILASLGV FT VTLLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGALAGLTTV FT VMVLMLGQCRVLFAMARDGLVPRQLAKTGSRGTPVRVTVLVAVLVATTASVFPITKLEE FT MVNVGTLFAFILVSAGVVVLRRTRPDLQRGFTAPWVPLLPIAAVCACLWLMLNLTALTW FT IRFGIWLVAGTAIYVGYGRRHSAQGLRQARESATRRC" FT CDS 145275..146663 FT /transl_table=11 FT /gene="Mb3282" FT /locus_tag="Mb3282" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3282, -, len: 462 aa. Equivalent to Rv3254, len: FT 462 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 462 aa overlap). Conserved hypothetical FT protein, similar to CAC37877|SC1G7.02 PUTATIVE SECRETED FT PROTEIN from Streptomyces coelicolor (440 aa), FASTA FT scores: opt: 606, E(): 6.2e-31, (31.7% identity in 445 aa FT overlap); O86550|SC1F2.13c HYPOTHETICAL 50.7 KDA PROTEIN FT from Streptomyces coelicolor (476 aa), FASTA scores: opt: FT 577, E(): 4.5e-29, (32.5% identity in 400 aa overlap); FT Q9L0A8|SCC24.09 PUTATIVE SECRETED PROTEIN from Streptomyces FT coelicolor (468 aa), FASTA scores: opt: 380, E(): 1.3e-16, FT (30.7% identity in 391 aa overlap); BAB48792|MLL1411 FT PROBABLE FAD-DEPENDENT MONOOXYGENASE from Rhizobium loti FT (Mesorhizobium loti) (421 aa), FASTA scores: opt: 128, E(): FT 1.1, (25.2% identity in 397 aa overlap); Q9L7X9|BENF FT BENZOATE-SPECIFIC PORIN-LIKE PROTEIN from Pseudomonas FT putida (397 aa), FASTA scores: opt: 119, E(): 4, (24.85% FT identity in 157 aa overlap); etc. Also similar to FT N-terminus of AAK46259|MT1987 PUTATIVE FERREDOXIN FT REDUCTASE, ELECTRON TRANSFER COMPONENT from Mycobacterium FT tuberculosis strain CDC1551 (839 aa), FASTA scores: opt: FT 493, E(): 1.5e-23, (30.65% identity in 382 aa overlap)." FT /db_xref="GOA:Q7TWW1" FT /db_xref="InterPro:IPR002937" FT /db_xref="UniProtKB/TrEMBL:Q7TWW1" FT /protein_id="CAD95374.1" FT /translation="MVIGASIAGLCAARVLSDFYSTVTVFERDELPEAPANRATVPQDR FT HLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENRPDCIYLGAAGHVLGTGHTLRKEFT FT AYVPSRPHLEWQLRRRVLQLSNVQIVRRLVTEPQFERRQQRVVGVLLDSPGSGQDRERE FT EFIAADLVVDAAGRGTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVV FT AGASHDQSLGLGMLCYEDGTWVLTTFGVADAKPPPTFDEMRALADKLLPARFTAALAQA FT QPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGMTMTSLQAGHLRR FT ALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDISFHHATAEPLPRWWRPAGSLFD FT QFLGAAETDPVLAEWFLRRFSLLDSLYMVPSVPIIGRAIAHNLRLWLKEQRERRQPVTT FT RRSP" FT CDS complement(146641..147867) FT /transl_table=11 FT /gene="manA" FT /locus_tag="Mb3283c" FT /product="PROBABLE MANNOSE-6-PHOSPHATE ISOMERASE MANA FT (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) FT (PHOSPHOHEXOISOMERASE) (PHOSPHOHEXOMUTASE)" FT /EC_number="5.3.1.8" FT /note="Mb3283c, manA, len: 408 aa. Equivalent to Rv3255c, FT len: 408 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 408 aa overlap). Probable manA, FT mannose-6-phosphate isomerase (EC 5.3.1.8), equivalent to FT Q9CCJ5|MANA|ML0765 from Mycobacterium leprae (410 aa), FT FASTA scores: opt: 2271, E(): 1.6e-133, (84.45% identity in FT 411 aa overlap). Also similar to many e.g. Q9KZL9|MANA from FT Streptomyces coelicolor (383 aa), FASTA scores: opt: 946, FT E(): 2.4e-51, (44.4% identity in 403 aa overlap); FT Q9KV87|VC0269 from Vibrio cholerae (399 aa), FASTA scores: FT opt: 726, E(): 1.1e-37, (34.15% identity in 404 aa FT overlap); Q9CMJ5|PMI|PM0829 from Pasteurella multocida (400 FT aa), FASTA scores: opt: 640, E(): 2.4e-32, (32.5% identity FT in 391 aa overlap); etc. SIMILAR TO FAMILY 1 OF FT MANNOSE-6-PHOSPHATE ISOMERASES." FT /db_xref="GOA:Q7TWW0" FT /db_xref="HSSP:1PMI" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:Q7TWW0" FT /protein_id="CAD95375.1" FT /translation="MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDP FT AWLQTPHGQTSLLEALVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHPSAEQ FT AVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRALAV FT SDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAE FT AKTVLELGERYPGDAGVLAALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNV FT LRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGD FT HLGHEVDASSGHDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPA FT KLFRATVGL" FT CDS complement(147875..148915) FT /transl_table=11 FT /gene="Mb3284c" FT /locus_tag="Mb3284c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3284c, -, len: 346 aa. Equivalent to Rv3256c, len: FT 346 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 346 aa overlap). Conserved hypothetical FT protein, equivalent to Q9CCJ6|ML0764 HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (365 aa), FASTA scores: opt: FT 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). FT Also similar to other hypothetical bacterial proteins e.g. FT Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FT FASTA scores: opt: 171, E(): 0.012, (31.1% identity in 376 FT aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain FT NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% FT identity in 233 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TWV9" FT /protein_id="CAD95376.1" FT /translation="MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGE FT LDLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVLIV FT AGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFGLSR FT YLAAGLAALQTVDPKLRIDLASLADELDAEALRNSAGREVFTNPAKALAARVSGCQLAL FT AGDNAATLALARHGSSVMLRIANQVVAATRLSDAVVALRAGTPPDALFHDEEIDGPAPQ FT RLRVLALALAGERTVVAARVAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRLEMAAVY FT LRLVRG" FT CDS complement(148912..150309) FT /transl_table=11 FT /gene="manB" FT /locus_tag="Mb3285c" FT /product="PROBABLE PHOSPHOMANNOMUTASE MANB (PMM) FT (PHOSPHOMANNOSE MUTASE)" FT /EC_number="5.4.2.8" FT /note="Mb3285c, manB, len: 465 aa. Equivalent to Rv3257c, FT len: 465 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 465 aa overlap). Probable manB, FT phosphomannomutase (EC 5.4.2.8) (see citation below), FT equivalent to Q9CCJ7|PMMA|ML0763 from Mycobacterium leprae FT (468 aa), FASTA scores: opt: 2533, E(): 2e-145, (83.1% FT identity in 468 aa overlap). Also similar to many e.g. FT Q9KZL6|MANB from Streptomyces coelicolor (454 aa), FASTA FT scores: opt: 1820, E(): 2e-102, (63.2% identity in 459 aa FT overlap); Q9PGN8|XF0260 from Xylella fastidiosa (500 aa), FT FASTA scores: opt: 1085, E(): 4.7e-58, (40.7% identity in FT 462 aa overlap); Q9EY19|MANB from Salmonella enterica FT subsp. arizonae (456 aa), FASTA scores: opt: 988, E(): FT 3.1e-52, (38.65% identity in 445 aa overlap); etc. BELONGS FT TO THE PHOSPHOHEXOSE MUTASES FAMILY. Note that previously FT known as pmmA." FT /db_xref="GOA:Q7TWV8" FT /db_xref="HSSP:1K35" FT /db_xref="InterPro:IPR016055" FT /db_xref="UniProtKB/TrEMBL:Q7TWV8" FT /protein_id="CAD95377.1" FT /translation="MSWPAAAVDRVIKAYDVRGLVGEEIDESLVTDLGAAFARLMRTED FT ARPVVIGHDMRDSSPSLADAFAAGVTGQGLDVVRVGLASTDQLYFASGLLDCPGAMFTA FT SHNPAAYNGIKMCRAAAKPVGADTGLTAIRDDLIAGVARYDGTPGTIADQDVLVDYGAF FT LRSLVDTSGLRPLRVAVDAGNGMAGHTAPAVLGVIDSITLLPLYFELDGSFPNHEANPL FT DPANLVDLQAYVRDTGADIGLAFDGDADRCFVVDERGQPVSPSTVTALVAARELNREIG FT ATIIHNVITSRAVPELVAERGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHYYFRDFW FT GADSGMLAALHVLAALGEQSRPLSELTADYQRYESSGEINFTVVDSSACVEAVLKSFGN FT RIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVEGRSVGDVDAVVRQVSAEIAAQS FT AHAKAGP" FT CDS complement(150411..150902) FT /transl_table=11 FT /gene="Mb3286c" FT /locus_tag="Mb3286c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3286c, -, len: 163 aa. Equivalent to Rv3258c, len: FT 163 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 163 aa overlap). Conserved hypothetical FT protein, equivalent to Q9CCJ8|ML0762 HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (165 aa), FASTA scores: opt: 840, FT E(): 9.9e-42, (76.9% identity in 169 aa overlap). Also FT similar to Q9KZL4|SCE34.11c HYPOTHETICAL 15.0 KDA PROTEIN FT from Streptomyces coelicolor (140 aa), FASTA scores: opt: FT 353, E(): 1.1e-13, (48.3% identity in 147 aa overlap); and FT shows really weak similarity to other bacterial proteins." FT /db_xref="UniProtKB/TrEMBL:Q7TWV7" FT /protein_id="CAD95378.1" FT /translation="MRVSGASAALVHDSLSVVNVPRRCCRPGCPHYAVATLTFVYSDST FT AVIGPLATAREPHSWDLCVGHAGRITAPRGWELVRHAGPLPSHPDEDDLVALADAVREG FT GPSAGRRHHPGGNGAPLHGFDDFPAAATGAPTGGGVLAPPEPGAGRRRGHLRVLPDPAD FT " FT CDS 151025..151444 FT /transl_table=11 FT /gene="Mb3287" FT /locus_tag="Mb3287" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3287, -, len: 139 aa. Equivalent to Rv3259, len: FT 139 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 139 aa overlap). Conserved hypothetical FT protein, equivalent, but shorter 29 aa, to Q9CCJ9|ML0761 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (167 aa), FT FASTA scores: opt: 846, E(): 2.2e-47, (89.2% identity in FT 139 aa overlap). C-terminus highly similar to Q9S425 FT HYPOTHETICAL 6.0 KDA PROTEIN (FRAGMENT) from Mycobacterium FT smegmatis (54 aa), FASTA scores: opt: 275, E(): 2.7e-11, FT (81.15% identity in 53 aa overlap). Also similar to FT Q9KZL3|SCE34.12 from Streptomyces coelicolor (117 aa), FT FASTA scores: opt: 152, E(): 0.004, (34.15% identity in 126 FT aa overlap). Equivalent to AAK47699 from Mycobacterium FT tuberculosis strain CDC1551 (175 aa) but shorter 36 aa." FT /db_xref="UniProtKB/TrEMBL:Q7TWV6" FT /protein_id="CAD95379.1" FT /translation="MRGPLLPPTVPGWRSRAERFDMAVLEAYEPIERRWQERVSQLDIA FT VDEIPRIAAKDPESVQWPPEVIADGPIALARLIPAGVDVRGNATRARIVLFRKPIERRA FT KDTEELGELLHEILVAQVAIYLDVDPSVIDPTIDD" FT CDS complement(151472..151741) FT /transl_table=11 FT /gene="whiB2" FT /locus_tag="Mb3288c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT WHIB-LIKE WHIB2" FT /note="Mb3288c, whiB2, len: 89 aa. Equivalent to Rv3260c, FT len: 89 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 89 aa overlap). Probable whiB2, FT WhiB-like regulatory protein (see first citation below), FT similar to WhiB paralogue of Streptomyces coelicolor, wblE FT gene product (85 aa). Equivalent to Q9CCK0|WHIB2|ML0760 FT PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium FT leprae (89 aa), FASTA scores: opt: 550, E(): 6.1e-31, FT (85.4% identity in 89 aa overlap). Also similar to others FT e.g. Q9S426 WHMD REGULATORY PROTEIN (see second citation FT below) from Mycobacterium smegmatis (129 aa), FASTA scores: FT opt: 488, E(): 1.4e-26, (83.55% identity in 85 aa overlap); FT Q06387|WHIB-STV WHIB-STV PROTEIN from Streptomyces FT griseocarneus (87 aa), FASTA scores: opt: 443, E(): FT 1.2e-23, (74.7% identity in 83 aa overlap); FT Q05429|WHIB|WHIB1 TRANSCRIPTION-LIKE FACTOR WHIB from FT Streptomyces aureofaciens (87 aa), FASTA scores: opt: 442, FT E(): 1.3e-23, (74.7% identity in 83 aa overlap); etc. FT Equivalent to AAK47700 WhiB-related protein from FT Mycobacterium tuberculosis strain CDC1551 (123 aa) but FT shorter 34 aa. Also similar to other Mycobacterium FT tuberculosis proteins: MTCY07D11.07c (45.1% identity in 71 FT aa overlap) and MTCY78.13c (37.4% identity in 91 aa FT overlap). Start chosen by homology but ORF continues to ATG FT upstream at 3754." FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q7TWV5" FT /protein_id="CAD95380.1" FT /translation="MVPEAPAPFEEPLPPEATDQWQDRALCAQTDPEAFFPEKGGSTRE FT AKKICMGCEVRHECLEYALAHDERFGIWGGLSERERRRLKRGII" FT CDS 152143..153138 FT /transl_table=11 FT /gene="fbiA" FT /locus_tag="Mb3289" FT /product="PROBABLE F420 BIOSYNTHESIS PROTEIN FBIA" FT /note="Mb3289, fbiA, len: 331 aa. Equivalent to Rv3261, FT len: 331 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 331 aa overlap). Probable fbiA, F420 FT biosynthesis protein, equivalent to FBIA F420 biosynthesis FT protein fbiA from Mycobacterium bovis BCG (see citations FT below). Also equivalent, but shorter 46 aa, to FT Q9CCK1|ML0759 HYPOTHETICAL PROTEIN from Mycobacterium FT leprae (379 aa), FASTA scores: opt: 1855, E(): 3.9e-110, FT (79.3% identity in 333 aa overlap). Also similar to others FT e.g. Q9KZK9|SCE34.17 HYPOTHETICAL 33.6 KDA PROTEIN from FT Streptomyces coelicolor (319 aa), FASTA scores: opt: 1151, FT E(): 1.2e-65, (55.1% identity in 332 aa overlap); FT O29345|AF0917 CONSERVED HYPOTHETICAL PROTEIN from FT Archaeoglobus fulgidus (296 aa), FASTA scores: opt: 469, FT E(): 1.7e-22, (31.15% identity in 302 aa overlap); FT Q58653|MJ1256 HYPOTHETICAL PROTEIN from Methanococcus FT jannaschii (311 aa), FASTA scores: opt: 436, E(): 2.2e-20, FT (27.35% identity in 274 aa overlap); etc." FT /db_xref="GOA:Q7TWV4" FT /db_xref="InterPro:IPR010115" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWV4" FT /protein_id="CAD95381.1" FT /translation="MKVTVLAGGVGGARFLLGVQQLLGLGQFAANSAHSDADHQLSAVV FT NVGDDAWIHGLRVCPDLDTCMYTLGGGVDPQRGWGQRDETWHAMQELVRYGVQPDWFEL FT GDRDLATHLVRTQMLQAGYPLSQITEALCDRWQPGARLLPATDDRCETHVVITDPVDES FT RKAIHFQEWWVRYRAQVPTHSFAFVGAEKSSAATEAIAALADADIIMLAPSNPVVSIGA FT ILAVPGIRAALREATAPIVGYSPIIGEKPLRGMADTCLSVIGVDSTAAAVGRHYGARCA FT TGILDCWLVHDGDHAEIDGVTVRSVPLLMTDPNATAEMVRAGCDLAGVVA" FT CDS 153135..154481 FT /transl_table=11 FT /gene="fbiB" FT /locus_tag="Mb3290" FT /product="PROBABLE F420 BIOSYNTHESIS PROTEIN FBIB" FT /note="Mb3290, fbiB, len: 448 aa. Equivalent to Rv3262, FT len: 448 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 448 aa overlap). Probable fbiB, F420 FT biosynthesis protein, equivalent to FBIB F420 biosynthesis FT protein fbiB from Mycobacterium bovis BCG (see citations FT below). Also equivalent to Q9CCK2|ML0758 PUTATIVE FT OXIDOREDUCTASE from Mycobacterium leprae (457 aa), FASTA FT scores: opt: 2411, E(): 3.5e-137, (82.25% identity in 445 FT aa overlap). Also similar to Q9KZK8|SCE34.18 PUTATIVE FT OXIDOREDUCTASE from Streptomyces coelicolor (443 aa), FASTA FT scores: opt: 1180, E(): 2.2e-63, (51.75% identity in 433 aa FT overlap); other oxidoreductases in C-terminus; and several FT hypothetical bacterial proteins." FT /db_xref="GOA:Q7TWV3" FT /db_xref="InterPro:IPR000415" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWV3" FT /protein_id="CAD95382.1" FT /translation="MTGPEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLRDGDV FT VVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDRTLITENRLGLVQA FT AAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLGVTVAVVITDTMGRAWRNGQTDA FT AVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAAAADLVKGKLTATPVAVVRGFGV FT SDDGSTARQLLRPGANDLFWLGTAEALELGRQQAQLLRRSVRRFSTDPVPGDLVEAAVA FT EALTAPAPHHTRPTRFVWLQTPAIRARLLDRMKDKWRSDLTSDGLPADAIERRVARGQI FT LYDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVRGLGSCWIG FT STIFAADLVRDELDLPVDWEPLGAIAIGYADEPSGLRDPVPAADLLILK" FT CDS 154777..156438 FT /transl_table=11 FT /gene="Mb3291" FT /locus_tag="Mb3291" FT /product="PROBABLE DNA METHYLASE (MODIFICATION METHYLASE) FT (METHYLTRANSFERASE)" FT /EC_number="2.1.1.-" FT /note="Mb3291, -, len: 553 aa. Equivalent to Rv3263, len: FT 553 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 553 aa overlap). Probable DNA methylase FT (EC 2.1.1.-), equivalent to Q9CCK4|ML0756 PROBABLE DNA FT METHYLASE from Mycobacterium leprae (555 aa), FASTA scores: FT opt: 2980, E(): 2.1e-184, (81.9% identity in 541 aa FT overlap). Also similar to others e.g. FT P25240|MT57_ECOLI|ECO57IM MODIFICATION METHYLASE from FT Escherichia coli (544 aa), FASTA scores: opt: 595, E(): FT 1e-30, (30.35% identity in 507 aa overlap); FT P25201|MTA1_ACICA|ACCIM MODIFICATION METHYLASE ACCI from FT Acinetobacter calcoaceticus (540 aa), FASTA scores: opt: FT 366, E(): 5.7e-16, (23.35% identity in 467 aa overlap); FT Q56752|M-ACCI ACCI METHYLASE from Bergeyella zoohelcum (541 FT aa), FASTA scores: opt: 365, E(): 6.6e-16, (22.95% identity FT in 466 aa overlap); etc. Contains PS00092 N-6 FT Adenine-specific DNA methylases signature. Alternative FT start site at aa 25." FT /db_xref="GOA:Q7TWV2" FT /db_xref="InterPro:IPR002296" FT /db_xref="UniProtKB/TrEMBL:Q7TWV2" FT /protein_id="CAD95383.1" FT /translation="MQPSHPTRPGAVIRYVGSSLDTCPMTTFAGKTAASADKVRGGYYT FT PPAVARFLAHWVHQAGPKILEPSCGDGRILRELSAITDHAHGVELVAREAKKSRDFASV FT DTENLFTWLHKTQLGSWDGVAGNPPYIRFGNWASEQRDPALELMRRVGLRPTKLTNAWV FT PFVVASTTLARDGGRVGLVVPAELLQVTYAAQLREFLLSRYREITLVTFERLVFDGILQ FT EVVLFCGVVGPGPAHIRTVRLGDANDLNALGDKDFTNESAPALLHEKEKWTKYFLDPAQ FT IRLLRGLKQSATMIRLGELADVDVGIVTGRNSFFTFTDAKAQALGLRAHCVPLVSRSAQ FT LSGLIYDEDCRACDVAGNHRTWLLDAADYPTDPALVAHITAGEAAGVHLGYKCSIRKPW FT WSTPSLWMPDLFMLRQIHFAPRLTVNAAAATSTDTVHRVRLDPNVDPATLAAVFHNSAT FT FAFAEIMGRSYGGGILELEPREAEQLPMPPPAYGSAELAQDVDLLLKANEIDKALDVVD FT RHVLIDGLGLSPRLVAGCRAAWLTLRDRRTKRGSRR" FT CDS complement(156498..157577) FT /transl_table=11 FT /gene="manC" FT /locus_tag="Mb3292c" FT /product="PROBABLE MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE FT MANC (GDP-MANNOSE PYROPHOSPHORYLASE) (GDP-MANNOSE FT PHOSPHORYLASE)" FT /EC_number="2.7.7.22" FT /note="Mb3292c, manC, len: 359 aa. Equivalent to Rv3264c, FT len: 359 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 359 aa overlap). Probable manC, FT mannose-1-phosphate guanyltransferase (EC 2.7.7.22), FT equivalent to Q9CCK6|RMLA2|ML0753 PUTATIVE SUGAR-PHOSPHATE FT NUCLEOTIDYL TRANSFERASE from Mycobacterium leprae (358 aa), FT FASTA scores: opt: 2075, E(): 2.7e-115, (86.9% identity in FT 359 aa overlap). Also similar to others e.g. FT Q9KZK6|SCE34.20c PUTATIVE NUCLEOTIDE PHOSPHORYLASE from FT Streptomyces coelicolor (360 aa), FASTA scores: opt: 1314, FT E(): 2.2e-70, (57.0% identity in 358 aa overlap); FT Q9KZP4|SC1A8A.08 PUTATIVE MANNOSE-1-PHOSPHATE FT GUANYLTRANSFERASE from Streptomyces coelicolor (831 aa), FT FASTA scores: opt: 699, E(): 8.6e-34, (34.45% identity in FT 354 aa overlap) (only similarity in N-terminus for this FT one); P74589|SLL1496 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE FT from Synechocystis sp. strain PCC 6803 (843 aa), FASTA FT scores: opt: 692, E(): 2.3e-33, (35.1% identity in 342 aa FT overlap) (only similarity in N-terminus for this one too); FT BAB59222|TVG0079558 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE FT from Thermoplasma volcanium (359 aa), FASTA scores: opt: FT 664, E(): 5.2e-32, (34.6% identity in 338 aa overlap); FT Q9ZTW5|GMP GDP-MANNOSE PYROPHOSPHORYLASE from Solanum FT tuberosum (Potato) (361 aa), FASTA scores: opt: 636, E(): FT 2.3e-30, (34.65% identity in 361 aa overlap); etc. BELONGS FT TO FAMILY 2 OF MANNOSE-6-PHOSPHATE ISOMERASES. Note that FT previously known as rmlA2." FT /db_xref="GOA:Q7TWV1" FT /db_xref="InterPro:IPR005835" FT /db_xref="UniProtKB/TrEMBL:Q7TWV1" FT /protein_id="CAD95384.1" FT /translation="MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSR FT IAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRND FT TAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEK FT TEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRD FT MGTPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGP FT GTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGA FT RVWPGVFLPDGGIRYSSDV" FT CDS complement(157579..158472) FT /transl_table=11 FT /gene="wbbL1" FT /locus_tag="Mb3293c" FT /standard_name="wbbL" FT /product="PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL FT POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WBBL1 FT ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENYL)" FT /EC_number="2.-.-.-" FT /note="Mb3293c, wbbL1, len: 297 aa. Equivalent to Rv3265c, FT len: 301 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.7% identity in 301 aa overlap). Probable wbbL1, FT dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL FT TRANSFERASE (EC 2.-.-.-) (see citation below), equivalent FT to Q9CCK7|WBBL|ML0752 PUTATIVE DTDP-RHAMNOSYL TRANSFERASE FT from Mycobacterium leprae (308 aa), FASTA scores: opt: FT 1788, E(): 3e-104, (85.05% identity in 301 aa overlap); and FT Q9RN50|WBBL|Q9RN49 (see note * below) FT DTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL, FT A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium smegmatis FT (296 aa), FASTA scores: opt: 1494, E(): 6.1e-86, (72.35% FT identity in 293 aa overlap). Note that previously known as FT wbbL. [* Note: UNPUBLISHED (experimental study on FT Mycobacterium smegmatis). Submitted (SEP-1999) to the FT EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan FT linker formation enzyme, dTDP-Rha:a-D-GlcNAc-diphosphoryl FT polyprenol, a-3-L-rhamnosyl transferase is essential for FT mycobacterial viability - Mills J.A., Motichka K., Jucker FT M., Wu H.P., Uhlic B.C., Stern R.J., Scherman M.S., Vissa FT V.D., Yan W., Pan F., Kimbrel S., Kundu M., McNeil M.]. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an FT in-frame deletion of 12 bp leads to a shorter product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (297 aa versus 301 aa)." FT /db_xref="GOA:Q7TTR5" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q7TTR5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95385.1" FT /translation="MVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAAV FT QRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGSID FT ALLDAASRWPRAGALGPLIRDPDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTTAYR FT QERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWLSVYV FT PSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLALRSHLM FT VRRSRRRKLKLVEGRH" FT CDS complement(158483..159397) FT /transl_table=11 FT /gene="rmlD" FT /locus_tag="Mb3294c" FT /product="POSSIBLE DTDP-RHAMNOSE MODIFICATION PROTEIN RMLD" FT /note="Mb3294c, rmld, len: 304 aa. Equivalent to Rv3266c, FT len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 304 aa overlap). Possible rmld, FT dTDP-rhamnose modification protein, highly similar to FT Q9CCK8 putative dTDP-rhamnose modification protein from FT Mycobacterium leprae (311 aa), FASTA scores, opt: 1440, FT E(): 1.1e-78, (74.7% identity in 312 aa overlap); and FT similar to several dtdp-4-dehydrorhamnose reductase (EC FT 1.1.1.133) e.g. STRL_STRGR|P29781 from Streptomyces griseus FT (304 aa), FASTA scores, opt: 788, E(): 0, (47.4% identity FT in 304 aa overlap).." FT /db_xref="GOA:Q7TWV0" FT /db_xref="HSSP:1KBZ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TWV0" FT /protein_id="CAD95386.1" FT /translation="MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDP FT AAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVST FT DYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGT FT GKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVV FT SRFGQARAVFEECGADPQRVRPVSSAQFPRPAPRPSYSALSSRQWALAGLTPLRHWRSA FT LATALAAPANSTSIDRRLPSTRD" FT CDS 159473..160969 FT /transl_table=11 FT /gene="Mb3295" FT /locus_tag="Mb3295" FT /product="CONSERVED HYPOTHETICAL PROTEIN (CPSA-RELATED FT PROTEIN)" FT /note="Mb3295, -, len: 498 aa. Equivalent to Rv3267, len: FT 498 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 498 aa overlap). Conserved hypothetical FT protein, CPSA-related protein, equivalent to Q9CCK9|ML0750 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (489 aa), FT FASTA scores: opt: 2523, E(): 5e-138, (78.9% identity in FT 498 aa overlap); and Q50160|CPSA (HYPOTHETICAL PROTEIN FT CPSA) from Mycobacterium leprae (516 aa), FASTA scores: FT opt: 868, E(): 1.2e-42, (34.7% identity in 507 aa overlap). FT Also similar to O06347|CPSA|Rv3484|MTCY13E12.37 CPSA from FT Mycobacterium tuberculosis (512 aa), FASTA scores: opt: FT 928, E(): 4.2e-46, (37.35% identity in 498 aa overlap); and FT O53834|Rv0822c|MTV043.14c HYPOTHETICAL 72.9 KDA PROTEIN FT from Mycobacterium tuberculosis (684 aa), FASTA scores: FT opt: 434, E(): 1.5e-17, (30.9% identity in 541 aa overlap). FT Also similar to Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL FT PROTEIN from Streptomyces coelicolor (507 aa), FASTA FT scores: opt: 437, E(): 8.1e-18, (28.55% identity in 469 aa FT overlap); O68907 FRNA PROTEIN from Streptomyces roseofulvus FT (770 aa), FASTA scores: opt: 388, E(): 7.6e-15, (32.6% FT identity in 267 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A." FT /db_xref="InterPro:IPR004474" FT /db_xref="UniProtKB/TrEMBL:Q7TWU9" FT /protein_id="CAD95387.1" FT /translation="MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFH FT MSAPSLGHGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILIRV FT PNNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAAGTE FT AGREALIKTVADLTGVTVDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGADFPAG FT RQKLNGPQALSFVRQRHDLPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLKRLEQA FT VQRSVVLSSGWDIMDFVRQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQD FT WVVGLLHEQDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNND FT GDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLANDYSGPGSGLGG FT SDPNGVVSPARAFNLGSADDTTPPPSPILTAGSDAPECIN" FT CDS 161008..161697 FT /transl_table=11 FT /gene="Mb3296" FT /locus_tag="Mb3296" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3296, -, len: 229 aa. Equivalent to Rv3268, len: FT 229 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 229 aa overlap). Conserved hypothetical FT protein, similar to Q9KZK4|SCE34.22 HYPOTHETICAL 27.1 KDA FT PROTEIN from Streptomyces coelicolor (263 aa), FASTA FT scores: opt: 442, E(): 5.9e-20, (40.1% identity in 242 aa FT overlap). Also weak similarity to N-terminal part FT (approximatively 1530 to 1740 residues) of O07944|SNBDE FT PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces FT pristinaespiralis (4848 aa), FASTA scores: opt: 159, E(): FT 0.11, (30.35% identity in 224 aa overlap)." FT /db_xref="GOA:Q7TWU8" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TWU8" FT /protein_id="CAD95388.1" FT /translation="MLRADPVGPRITYYDDATGERIELSAVTLANWAAKTGNLLRDELA FT AGPASRVAILLPAHWQTAAVLFGVWWIGAQAILDDSPADVALCTADRLAEADAVVNSAA FT VAGEVAVLSLDPFGRPATGLPVGVTDYATAVRVHGDQIVPEHNPGPVLAGRSVEQILRD FT CAASAAARGLTAADRVLSTASWAGPDELVDGLLAILAAGASLVQVANPDPAMLQRRIAT FT EKVTRVL" FT CDS 161822..162103 FT /transl_table=11 FT /gene="Mb3297" FT /locus_tag="Mb3297" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3297, -, len: 93 aa. Equivalent to Rv3269, len: 93 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 93 aa overlap). Conserved hypothetical protein, FT similar to many Mycobacterium proteins and chaperonins/heat FT shock proteins e.g. Q9CCL0|ML0748 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (92 aa), FASTA scores: opt: 427, E(): FT 6.8e-21, (73.65% identity in 91 aa overlap); FT Q10865|Rv1993c|MT2049|MTCY39.26c HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (90 aa), FASTA scores: opt: 313, FT E(): 1.2e-13, (60.7% identity in 84 aa overlap); FT P71542|Y968_MYCTU|Rv0968|MTCY10D7.06c (98 aa), FASTA FT scores: opt: 294, E(): 2.2e-12, (55.1% identity in 98 aa FT overlap); Q50827|MOPA|GROEL|CH60_MYCVA CHAPERONIN (PROTEIN FT CPN60) from Mycobacterium vaccae (120 aa), FASTA scores: FT opt: 107, E(): 2.1, (39.5% identity in 81 aa overlap); FT Q9AEB3|HSP65 HEAT SHOCK PROTEIN (FRAGMENT) from FT Mycobacterium gadium (122 aa), FASTA scores: opt: 102, E(): FT 4.4, (38.25% identity in 81 aa overlap); FT Q49374|CH60_MYCGN|MOPA|GROEL CHAPERONIN (PROTEIN CPN60) FT from Mycobacterium genavense (120 aa), FASTA scores: opt: FT 99, E(): 6.8, (40.25% identity in 82 aa overlap); etc." FT /db_xref="InterPro:IPR009963" FT /db_xref="UniProtKB/TrEMBL:Q7TWU7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95389.1" FT /translation="MAIQVFLAKATTTVITGLAGVTAYEILKKAAAKAPLRQTAVSAAA FT LGLRGTRKAEEAAESARLKVADVMAEARERIGEESPTPAISDLHDHDH" FT CDS 162114..164270 FT /transl_table=11 FT /gene="ctpC" FT /locus_tag="Mb3298" FT /product="PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE FT C CTPC" FT /EC_number="3.6.3.-" FT /note="Mb3298, ctpC, len: 718 aa. Equivalent to Rv3270, FT len: 718 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 718 aa overlap). Probable ctpC, metal FT cation-transport ATPase P-type (EC 3.6.3.-), integral FT membrane protein, equivalent to Q9CCL1|CTPC|ML0747 PUTATIVE FT CATION TRANSPORT ATPASE from Mycobacterium leprae (725 aa), FT FASTA scores: opt: 3908, E(): 0, (85.95% identity in 713 aa FT overlap). Also similar to O66027|MTAA METAL TRANSPORTING FT ATPASE MTA72 from Mycobacterium tuberculosis (680 aa), FT FASTA scores: opt: 3756, E(): 5.5e-213, (91.45% identity in FT 679 aa overlap); and to other ATPases e.g. FT Q9ZHC7|SILP_SALTY PUTATIVE CATION TRANSPORTING P-TYPE FT ATPASE from Salmonella typhimurium (824 aa), FASTA scores: FT opt: 1145, E(): 1.3e-59, (36.55% identity in 643 aa FT overlap); Q9HX93|PA3920 PROBABLE METAL TRANSPORTING P-TYPE FT ATPASE from Pseudomonas aeruginosa (792 aa), FASTA scores: FT opt: 1140, E(): 2.4e-59, (35.95% identity in 745 aa FT overlap); etc. Contains PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB." FT /db_xref="GOA:P0A503" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:P0A503" FT /protein_id="CAD95390.1" FT /translation="MTLEVVSDAAGRMRVKVDWVRCDSRRAVAVEEAVAKQNGVRVVHA FT YPRTGSVVVWYSPRRADRAAVLAAIKGAAHVAAELIPARAPHSAEIRNTDVLRMVIGGV FT ALALLGVRRYVFARPPLLGTTGRTVATGVTIFTGYPFLRGALRSLRSGKAGTDALVSAA FT TVASLILRENVVALTVLWLLNIGEYLQDLTLRRTRRAISELLRGNQDTAWVRLTDPSAG FT SDAATEIQVPIDTVQIGDEVVVHEHVAIPVDGEVVDGEAIVNQSAITGENLPVSVVVGT FT RVHAGSVVVRGRVVVRAHAVGNQTTIGRIISRVEEAQLDRAPIQTVGENFSRRFVPTSF FT IVSAIALLITGDVRRAMTMLLIACPCAVGLSTPTAISAAIGNGARRGILIKGGSHLEQA FT GRVDAIVFDKTGTLTVGRPVVTNIVAMHKDWEPEQVLAYAASSEIHSRHPLAEAVIRST FT EERRISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLRAEKVRVSKKASEWVDKLRRQ FT AETPLLLAVDGTLVGLISLRDEVRPEAAQVLTKLRANGIRRIVMLTGDHPEIAQVVADE FT LGIDEWRAEVMPEDKLAAVRELQDDGYVVGMVGDGINDAPALAAADIGIAMGLAGTDVA FT VETADVALANDDLHRLLDVGDLGERAVDVIRQNYGMSIAVNAAGLLIGAGGALSPVLAA FT ILHNASSVAVVANSSRLIRYRLDR" FT CDS complement(164267..164935) FT /transl_table=11 FT /gene="Mb3299c" FT /locus_tag="Mb3299c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb3299c, -, len: 222 aa. Equivalent to Rv3271c, len: FT 222 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 222 aa overlap). Probable conserved FT integral membrane protein, similar to others e.g. FT Q9RD35|SCM1.07c from Streptomyces coelicolor (230 aa), FT FASTA scores: opt: 360, E(): 4.7e-16, (33.85% identity in FT 195 aa overlap); Q9X897|SCE2.02c from Streptomyces FT coelicolor (234 aa), FASTA scores: opt: 357, E(): 7.3e-16, FT (33.85% identity in 195 aa overlap); Q9D0E0 2610024A01RIK FT PROTEIN from Mus musculus (Mouse) (288 aa), FASTA scores: FT opt: 191, E(): 3.7e-05, (23.65% identity in 207 aa FT overlap)." FT /db_xref="GOA:Q7TWU6" FT /db_xref="InterPro:IPR002524" FT /db_xref="UniProtKB/TrEMBL:Q7TWU6" FT /protein_id="CAD95391.1" FT /translation="METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLLT FT EGAVGLWQGIAVGSVALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVAVS FT FWLTAPYLVAESIRHLAGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSGATA FT GEGTQNYLCAAQAAAVLLGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGHGCGC FT " FT CDS 165036..166220 FT /transl_table=11 FT /gene="Mb3300" FT /locus_tag="Mb3300" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3300, -, len: 394 aa. Equivalent to Rv3272, len: FT 394 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 394 aa overlap). Conserved hypothetical FT protein, similar to various proteins e.g. Q9I672|PA0446 FT HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (407 aa), FT FASTA scores: opt: 643, E(): 6.8e-32, (33.15% identity in FT 389 aa overlap); Q9RJU8|SCF41.21 PUTATIVE RACEMASE from FT Streptomyces coelicolor (403 aa), FASTA scores: opt: 541, FT E(): 1.1e-25, (31.95% identity in 385 aa overlap); FT O87838|SC8A6.04c PUTATIVE TRANSFERASE from Streptomyces FT coelicolor (410 aa), FASTA scores: opt: 539, E(): 1.5e-25, FT (29.95% identity in 395 aa overlap); Q9I563|PA0882 from FT Pseudomonas aeruginosa (400 aa), FASTA scores: opt: 530, FT E(): 5.2e-25, (28.8% identity in 396 aa overlap); FT BAB60328|TVG1215416 L-CARNITINE DEHYDRATASE from FT Thermoplasma volcanium (399 aa), FASTA scores: opt: 529, FT E(): 6e-25, (32.9% identity in 383 aa overlap); etc. FT C-terminus is similar to Q49678|U00012_27|B1308_C3_195 from FT Mycobacterium leprae (130 aa) (60.0% identity in 115 aa FT overlap). Also partially similar to MTCY359_7 from M. FT tuberculosis (778 aa) (29.9% identity in 388 aa overlap)." FT /db_xref="GOA:Q7TWU5" FT /db_xref="HSSP:1PQY" FT /db_xref="InterPro:IPR003673" FT /db_xref="UniProtKB/TrEMBL:Q7TWU5" FT /protein_id="CAD95392.1" FT /translation="MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPG FT GEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVLEAFR FT PGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVAAEAGMTTGMPTPE FT GKPQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQANQLMMHL FT NRAASDQPKPEPAPKAKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRP FT DLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVD FT TPLFAESDLTLEVGRGADTITVIRTPARYASFRAVVTDPPPTAGEHNAVFLARP" FT CDS 166225..168519 FT /transl_table=11 FT /gene="Mb3301" FT /locus_tag="Mb3301" FT /product="PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE FT (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)" FT /EC_number="4.2.1.1" FT /note="Mb3301, -, len: 764 aa. Equivalent to Rv3273, len: FT 764 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 764 aa overlap). Probable transmembrane FT protein (N-terminal part is hydrophobic) with probable FT carbonic anhydrase activity (in C-terminal part) (EC FT 4.2.1.1). Possibly involved in transport of sulfate. FT Equivalent to Q9CBA3|ML2279 PUTATIVE TRANSMEMBRANE FT TRANSPORT PROTEIN from Mycobacterium leprae (496 aa), FASTA FT scores: opt: 1637, E(): 1.8e-89, (59.15% identity in 487 aa FT overlap). Similar to various proteins (principally sulfate FT transporters) e.g. Q9X927|SCH5.25 PUTATIVE INTEGRAL FT MEMBRANE PROTEIN from Streptomyces coelicolor (830 aa), FT FASTA scores: opt: 1325, E(): 8e-71, (40.85% identity in FT 788 aa overlap); Q9I729|PA0103 PROBABLE SULFATE TRANSPORTER FT from Pseudomonas aeruginosa (523 aa), FASTA scores: opt: FT 1015, E(): 1.3e-52, (39.95% identity in 488 aa overlap); FT Q9KN88|VCA0077 SULFATE PERMEASE FAMILY PROTEIN from Vibrio FT cholerae (553 aa), FASTA scores: opt: 629, E(): 9.6e-30, FT (30.95% identity in 423 aa overlap); etc. C-terminal part FT (aa 550-764) shows similarity to carbonic anhydrase e.g. FT P27134|CYNT_SYNP7 CARBONIC ANHYDRASE (EC 4.2.1.1) (272 aa), FT FASTA scores: opt: 350, E(): 8.1e-15, (33.8% identity in FT 201 aa overlap). Contains PS00704 Prokaryotic-type carbonic FT anhydrases signature 1. SEEMS TO BELONG TO THE SULP FT FAMILY." FT /db_xref="GOA:Q7TWU4" FT /db_xref="InterPro:IPR011547" FT /db_xref="UniProtKB/TrEMBL:Q7TWU4" FT /protein_id="CAD95393.1" FT /translation="MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVA FT LPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELIDELGW FT PMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIALQQIHVLLGGTSH FT SSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGATVLA FT LLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVESLL FT SAVGVDKLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIVRSSANVAAGARTRMST FT ILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNFVIYAITI FT VCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDGTLSFLLLP FT RLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVETSPAKLHHA FT HARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHPHIAGLTDSQD FT PYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVS FT SVVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRSAESAGYPE FT ADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEP FT ADRPVDHESAQ" FT CDS complement(168508..169677) FT /transl_table=11 FT /gene="fadE25" FT /locus_tag="Mb3302c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE25" FT /EC_number="1.3.99.-" FT /note="Mb3302c, fadE25, len: 389 aa. Equivalent to Rv3274c, FT len: 389 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 389 aa overlap). Probable fadE25, FT Acyl-CoA Dehydrogenase (EC 1.3.99.-), equivalent to FT P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE FT ACYL-COA DEHYDROGENASE FADE25 from Mycobacterium leprae FT (389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05% FT identity in 389 aa overlap). Also similar to many e.g. FT Q9RIQ5|FADE FATTY ACID ACYL-COA DEHYDROGENASE from FT Streptomyces lividans (385 aa), FASTA scores: opt: 1692, FT E(): 4.9e-99, (67.35% identity in 383 aa overlap); FT P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa), FT FASTA scores: opt: 1212, E(): 7.2e-69, (51.85% identity in FT 376 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus FT halodurans (380 aa), FASTA scores: opt: 1209, E(): 1.1e-68, FT (51.7% identity in 377 aa overlap); P52042|ACDS_CLOAB|BCD FT from Clostridium acetobutylicum (379 aa), FASTA scores: FT opt: 1056, E(): 4.6e-59, (44.6% identity in 379 aa FT overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases FT signature 1, PS00073 Acyl-CoA dehydrogenases signature 2. FT BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY." FT /db_xref="GOA:P63428" FT /db_xref="HSSP:1JQI" FT /db_xref="InterPro:IPR006091" FT /db_xref="UniProtKB/Swiss-Prot:P63428" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95394.1" FT /translation="MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKA FT RFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVNKLGT FT MGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILNGAK FT CWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELY FT FENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQFG FT ESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFISAASKCFASDVAMEV FT TTDAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR" FT CDS complement(169702..170226) FT /transl_table=11 FT /gene="purE" FT /locus_tag="Mb3303c" FT /product="PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE FT CATALYTIC SUBUNIT PURE (AIR CARBOXYLASE) (AIRC)" FT /EC_number="4.1.1.21" FT /note="Mb3303c, purE, len: 174 aa. Equivalent to Rv3275c, FT len: 174 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 174 aa overlap). Probable purE, FT phosphoribosylaminoimidazole carboxylase catalytic subunit FT (EC 4.1.1.21), equivalent to FT P46702|PUR6_MYCLE|PURE|ML0736|B1308_F3_98 from FT Mycobacterium leprae (171 aa), FASTA scores: opt: 878, E(): FT 1.5e-43, (81.55% identity in 168 aa overlap). Also similar FT to others e.g. Q9AXD0|AIRC from Nicotiana tabacum (Common FT tobacco) (623 aa), FASTA scores: opt: 712, E(): 1.4e-33, FT (69.35% identity in 160 aa overlap) (similarity in FT C-terminal part for this one); Q44679|PUR6_CORAM from FT Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) FT (177 aa), FASTA scores: opt: 651, E(): 1.5e-30, (68.25% FT identity in 148 aa overlap); Q55498|PUR6_SYNY3|PURE|SLL0901 FT from Synechocystis sp. strain PCC 6803 (176 aa), FASTA FT scores: opt: 639, E(): 7.1e-30, (60.5% identity in 167 aa FT overlap); etc." FT /db_xref="GOA:Q7TWU3" FT /db_xref="HSSP:1O4V" FT /db_xref="InterPro:IPR000031" FT /db_xref="UniProtKB/TrEMBL:Q7TWU3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95395.1" FT /translation="MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAH FT RTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLDSL FT LSIVQMPAGVPVATVSIGGARNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKDAE FT LQRLAGKLTRD" FT CDS complement(170223..171512) FT /transl_table=11 FT /gene="purK" FT /locus_tag="Mb3304c" FT /product="PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE FT ATPASE SUBUNIT PURK (AIR CARBOXYLASE) (AIRC)" FT /EC_number="4.1.1.21" FT /note="Mb3304c, purK, len: 429 aa. Equivalent to Rv3276c, FT len: 429 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 429 aa overlap). Probable purK, FT phosphoribosylaminoimidazole carboxylase ATPase subunit (EC FT 4.1.1.21), equivalent to FT P46701|PURK_MYCLE|ML0735|B1308_F1_32 FT PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT FT from Mycobacterium leprae (439 aa), FASTA scores: opt: FT 2168, E(): 2.3e-123, (76.15% identity in 444 aa overlap). FT Also similar to others e.g. Q44678|PURK_CORAM from FT Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) FT (413 aa), FASTA scores: opt: 1179, E(): 9.1e-64, (48.35% FT identity in 389 aa overlap); Q9KZ85|PURK from Streptomyces FT coelicolor (368 aa), FASTA scores: opt: 1150, E(): 4.7e-62, FT (55.35% identity in 345 aa overlap); Q54975|PURK_SYNP7 from FT Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) FT (395 aa), FASTA scores: opt: 772, E(): 3e-39, (38.1% FT identity in 383 aa overlap); etc. BELONGS TO THE PURK / FT PURT FAMILY." FT /db_xref="GOA:P65899" FT /db_xref="HSSP:1B6R" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/Swiss-Prot:P65899" FT /protein_id="CAD95396.1" FT /translation="MMAVASSRTPAVTSFIAPLVAMVGGGQLARMTHQAAIALGQNLRV FT LVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGADVLTFDHEHVPNELLEKLVADGVNV FT APSPQALVHAQDKLVMRQRLAAAGVAVPRYAGIKDPDEIDVFAARVDAPIVVKAVRGGY FT DGRGVRMARDVADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAWPVVQ FT TVQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETTDGALLVNE FT LAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPVTVMANVLGAAQPPAMSV FT DERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGSDVAQLCERAELAAHWLSHGRWT FT DGWDPHRASDDAVGVPPACGGRSDEEERRL" FT CDS 171466..172284 FT /transl_table=11 FT /gene="Mb3305" FT /locus_tag="Mb3305" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb3305, -, len: 271 aa. Equivalent to Rv3277, len: FT 271 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 271 aa overlap). Probable conserved FT transmembrane protein, equivalent, but longer 49 aa, to FT Q49673|B1308_C1_121|ML0734 PUTATIVE MEMBRANE PROTEIN from FT Mycobacterium leprae (228 aa), FASTA scores: opt: 1266, FT E(): 6.1e-78, (84.2% identity in 228 aa overlap). Also FT similar to various proteins (principally unknowns) e.g. FT Q9KZ84|SCE25.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from FT Streptomyces coelicolor (190 aa), FASTA scores: opt: 197, FT E(): 3.6e-06, (32.0% identity in 150 aa overlap); FT BAB50058|MLL3086 HYPOTHETICAL PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (136 aa), FASTA scores: opt: 176, E(): FT 6.9e-05, (34.7% identity in 147 aa overlap); O29640|AF0615 FT HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (129 aa), FT FASTA scores: opt: 120, E(): 0.38, (23.35% identity in 120 FT aa overlap); Q9KJU8|GTCA TEICHOIC ACID GLYCOSYLATION FT PROTEIN from Listeria innocua (145 aa), FASTA scores: opt: FT 117, E(): 0.67, (23.85% identity in 151 aa overlap); etc. FT Equivalent to AAK47718 from Mycobacterium tuberculosis FT strain CDC1551 (256 aa) but longer 16 aa. Contains PS00044 FT Bacterial regulatory proteins, lysR family signature." FT /db_xref="GOA:Q7TWU2" FT /db_xref="InterPro:IPR007267" FT /db_xref="UniProtKB/TrEMBL:Q7TWU2" FT /protein_id="CAD95397.1" FT /translation="MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSSV FT HSLVVSFADATIARLPGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEPKP FT VTAKVIAGIVAVIASYVLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWFSSY FT ILQLRVPTVSLTMENIADFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKALESAL FT TAGGIAEVFEDVLEGGFEDGNVTLLRAWRNRANRFAQLGDSSEPRVSKTL" FT CDS complement(172239..172757) FT /transl_table=11 FT /gene="Mb3306c" FT /locus_tag="Mb3306c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb3306c, -, len: 172 aa. Equivalent to Rv3278c, len: FT 172 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 172 aa overlap). Probable conserved FT transmembrane protein, equivalent to Q9CCL2|ML0733 PUTATIVE FT MEMBRANE PROTEIN from Mycobacterium leprae (172 aa), FASTA FT scores: opt: 1024, E(): 6e-61, (83.15% identity in 172 aa FT overlap); and Q49672|B1308_F2_67 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (181 aa), FASTA scores: opt: 1024, FT E(): 6.3e-61, (83.15% identity in 172 aa overlap) (this is FT certainly the same putative protein but with N-terminus FT longer). Also some similarity to other hypothetical FT proteins (generally membrane proteins) e.g. O26822|MTH726 FT HYPOTHETICAL PROTEIN from Methanobacterium FT thermoautotrophicum (204 aa), FASTA scores: opt: 147, E(): FT 0.0079, (24.6% identity in 187 aa overlap); Q9X8H4|SCE9.01 FT HYPOTHETICAL 47.7 KDA PROTEIN (FRAGMENT) from Streptomyces FT coelicolor (436 aa), FASTA scores: opt: 151, E(): 0.0079, FT (28.1% identity in 153 aa overlap)." FT /db_xref="GOA:Q7TWU1" FT /db_xref="InterPro:IPR005182" FT /db_xref="UniProtKB/TrEMBL:Q7TWU1" FT /protein_id="CAD95398.1" FT /translation="MSYPENVLAAGEQVVLHRHPHWNRLIWPVVVLVLLTGLAAFGSGF FT VNSTPWQQIAKNVIHAVIWGIWLVIVGWLTLWPFLSWLTTHFVVTNRRVMFRHGVLTRS FT GIDIPLARINSVEFRDRIFERIFRTGTLIIESASQDPLEFYNIPRLREVHALLYHKVFD FT TLGSDESPS" FT CDS complement(172800..173600) FT /transl_table=11 FT /gene="birA" FT /locus_tag="Mb3307c" FT /product="POSSIBLE BIFUNCTIONAL PROTEIN BIRA: BIOTIN OPERON FT REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE FT (BIOTIN--PROTEIN LIGASE)" FT /EC_number="6.3.4.15" FT /note="Mb3307c, birA, len: 266 aa. Equivalent to Rv3279c, FT len: 266 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 266 aa overlap). Possible birA, FT bifunctional protein: biotin operon repressor and FT biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15), FT equivalent to Q9CCL3|BIRA|ML0732 BIOTIN APO-PROTEIN LIGASE FT from Mycobacterium leprae (274 aa), FASTA scores: opt: FT 1189, E(): 2.3e-66, (71.2% identity in 271 aa overlap). But FT as it lacks a BirA h-t-h domain at N-terminus, may simply FT be biotin apo-protein ligase. Also similar to others e.g. FT Q9CNX6|BIRA|PM0296 from Pasteurella multocida (312 aa), FT FASTA scores: opt: 347, E(): 2.7e-14, (32.95% identity in FT 270 aa overlap); Q9HWC0|BIRA|PA4280 from Pseudomonas FT aeruginosa (312 aa), FASTA scores: opt: 335, E(): 1.5e-13, FT (34.2% identity in 272 aa overlap); Q9A6Z0|CC1936 from FT Caulobacter crescentus (250 aa), FASTA scores: opt: 332, FT E(): 1.9e-13, (33.6% identity in 238 aa overlap); FT P06709|BIRA_ECOLI (321 aa), FASTA scores: opt: 314, E(): FT 3.1e-12, (34.15% identity in 249 aa overlap); etc. SIMILAR FT WITH OTHER BACTERIAL BIRA AND WITH EUKARYOTIC BIOTIN FT APO-PROTEIN LIGASE." FT /db_xref="GOA:Q7TWU0" FT /db_xref="HSSP:1BIB" FT /db_xref="InterPro:IPR004408" FT /db_xref="UniProtKB/TrEMBL:Q7TWU0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95399.1" FT /translation="MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLA FT RAASGADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLSLA FT AGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVTQAP FT EEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAANYRARSLTIGSR FT VRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR" FT CDS 173650..175296 FT /transl_table=11 FT /gene="accD5" FT /locus_tag="Mb3308" FT /product="PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 FT ACCD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)" FT /EC_number="6.4.1.3" FT /note="Mb3308, accD5, len: 548 aa. Equivalent to Rv3280, FT len: 548 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 548 aa overlap). Probable accD5, FT propyonyl-CoA carboxylase beta chain 5 (EC 6.4.1.3), FT equivalent to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 FT PROBABLE PROPIONYL-COA CARBOXYLASE BETA CHAIN 5 from FT Mycobacterium leprae (549 aa), FASTA scores: opt: 3241, FT E(): 4e-192, (88.7% identity in 549 aa overlap). Also FT similar to many e.g. O87201|DTSR2 DTSR2 PROTEIN INVOLVED IN FT GLUTAMATE PRODUCTION from orynebacterium glutamicum FT (Brevibacterium flavum) (537 aa), FASTA scores: opt: 2604, FT E(): 6.9e-153, (74.1% identity in 529 aa overlap) (see FT first citation below); P53003|PCCB_SACER from FT Saccharopolyspora erythraea (Streptomyces erythraeus) (546 FT aa), FASTA scores: opt: 2466, E(): 2.2e-144, (70.2% FT identity in 530 aa overlap); O88155|DTSR1 DTSR1 PROTEIN FT from Corynebacterium glutamicum (Brevibacterium flavum) FT (543 aa), FASTA scores: opt: 2375, E(): 8.8e-139, (67.1% FT identity in 529 aa overlap (see citation below); FT Q9X4K7|PCCB from Streptomyces coelicolor (530 aa), FASTA FT scores: opt: 2360, E(): 7.3e-138, (67.9% identity in 533 aa FT overlap); O24789|MXPCCB from Myxococcus xanthus (524 aa), FT FASTA scores: opt: 1868, E(): 1.5e-107, (56.85% identity in FT 524 aa overlap); etc. Also similar with METHYLMALONYL-COA FT DECARBOXYLASES e.g. O59018|PH1287 from Pyrococcus FT horikoshii (522 aa), FASTA scores: opt: 1841, E(): FT 6.7e-106, (54.15% identity in 528 aa overlap). Also FT similarity with MTCY427.28 (43.8% identity in 434 aa FT overlap). BELONGS TO THE ACCD/PCCB FAMILY." FT /db_xref="GOA:Q7TWT9" FT /db_xref="InterPro:IPR011762" FT /db_xref="UniProtKB/TrEMBL:Q7TWT9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95400.1" FT /translation="MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGE FT DAVEKVHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVTGYGT FT IDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVS FT LGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITGPDVI FT KTVTGEEVTMEELGGAHTHMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRYQ FT AAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITRLLDDEFLEIQAGYAQNIVVG FT FGRIDGRPVGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTD FT QEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDANLAWPTAQIA FT VMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDTLVNPYVAAERGYVDAVIPP FT SHTRGYIGTALRLLERKIAQLPPKKHGNVPL" FT CDS 175277..175747 FT /transl_table=11 FT /gene="Mb3309" FT /locus_tag="Mb3309" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3309, -, len: 156 aa. Similar to Rv3281, len: 177 FT aa, from Mycobacterium tuberculosis strain H37Rv, (88.1% FT identity in 177 aa overlap). Conserved hypothetical FT protein, equivalent (but longer 14 aa and with a gap FT between aa 82-102) to AAK47723|MT3380 from Mycobacterium FT tuberculosis strain CDC1551 (142 aa), FASTA scores: opt: FT 830, E(): 3.1e-40, (86.5% identity in 163 aa overlap). FT C-terminus highly similar to Q49671|B1308_C3_211|ML0730 FT from Mycobacterium leprae (84 aa), FASTA scores: opt: 393, FT E(): 7.6e-16, (68.95% identity in 87 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an FT in-frame deletion of 63 bp leads to a shorter product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (156 aa versus 177 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7TWT8" FT /protein_id="CAD95401.1" FT /translation="MGTCPCESSERNEPVSRVSGTNEVSDGNETNNPAEVSDGNETNNP FT AEVSDGNETNNPAPVSRVSGTNEVSDGNETNNPAPVTEKPLHPHEPHIEILRGQPTDQE FT LAALIAVLGSISGSTPPAQPEPTRWGLPVDQLRYPVFSWQRITLQEMTHMRR" FT CDS 175744..176412 FT /transl_table=11 FT /gene="Mb3310" FT /locus_tag="Mb3310" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3310, -, len: 222 aa. Equivalent to Rv3282, len: FT 222 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 222 aa overlap). Conserved hypothetical FT protein, equivalent to Q49670|ML0729 1308R (HYPOTHETICAL FT PROTEIN ML0729) from Mycobacterium leprae (213 aa), FASTA FT scores: opt: 945, E(): 5.5e-54, (68.55% identity in 213 aa FT overlap). Also similar to Q9EWV6|2SCK31.18 CONSERVED FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (206 aa), FT FASTA scores: opt: 459, E(): 1.3e-22, (47.35% identity in FT 209 aa overlap); P74331|MAF OR SLL0905 MAF PROTEIN from FT Synechocystis sp. strain PCC 6803 (195 aa), FASTA scores: FT opt: 401, E(): 6.9e-19, (43.0% identity in 207 aa overlap); FT and shows weak similarity with various proteins e.g. Q9BUL6 FT ACETYLSEROTONIN O-METHYLTRANSFERASE-LIKE from Homo sapiens FT (Human) (621 aa), FASTA scores: opt: 282, E(): 8.9e-11, FT (31.6% identity in 193 aa overlap); O95671|ASMTL ASMTL FT PROTEIN from Homo sapiens (Human) (629 aa), FASTA scores: FT opt: 282, E(): 9e-11, (31.6% identity in 193 aa overlap); FT BAB51136|MLR4491 MAF PROTEIN from Rhizobium loti FT (Mesorhizobium loti) (199 aa), FASTA scores: opt: 269, E(): FT 2.3e-10, (29.3% identity in 198 aa overlap); etc." FT /db_xref="GOA:Q7TWT7" FT /db_xref="InterPro:IPR003697" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWT7" FT /protein_id="CAD95402.1" FT /translation="MTRLVLGSASPGRLKVLRDAGIEPLVIASHVDEDVVIAALGPDAV FT PSDVVCVLAAAKAAQVATTLTGTQRIVAADCVVVACDSMLYIEGRLLGKPASIDEAREQ FT WRSMAGRAGQLYTGHGVIRLQDNKTVYRSAETAITTVYFGTPSASDLEAYLASGESLRV FT AGGFTLDGLGGWFIDGVQGNPSNVIGLSLPLLRSLVQRCGLSVAALWAGNAGGPAHKQQ FT " FT CDS 176453..177346 FT /transl_table=11 FT /gene="sseA" FT /locus_tag="Mb3311" FT /product="PROBABLE THIOSULFATE SULFURTRANSFERASE SSEA FT (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) FT (THIOSULFATE THIOTRANSFERASE)" FT /EC_number="2.8.1.1" FT /note="Mb3311, sseA, len: 297 aa. Equivalent to Rv3283, FT len: 297 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 297 aa overlap). Probable sseA, FT thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent FT P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 PUTATIVE FT THIOSULFATE SULFURTRANSFERASE SSEA from Mycobacterium FT leprae (296 aa), FASTA scores: opt: 1742, E(): 5.5e-108, FT (83.45% identity in 296 aa overlap). Also highly similar to FT others e.g. Q9RXT9|DR0217 from Deinococcus radiodurans (286 FT aa), FASTA scores: opt: 1057, E(): 1.2e-62, (53.86% FT identity in 273 aa overlap); P16385|THTR_SACER|CYSA from FT Saccharopolyspora erythraea (Streptomyces erythraeus) (281 FT aa), FASTA scores: opt: 1006, E(): 2.7e-59, (51.25% FT identity in 277 aa overlap); P71121|THTR_CORGL from FT Corynebacterium glutamicum (Brevibacterium flavum) (225 FT aa), FASTA scores: opt: 897, E(): 3.6e-52, (59.05% identity FT in 215 aa overlap); etc. Also highly similar to FT O05793|CYSA1|CYSA|Rv3117|MT3199|MTCY164.27|CYSA2|RV0815c|MT FT 0837|MTV043.07c|THTR_MYCTU PUTATIVE THIOSULFATE FT SULFURTRANSFERASE (EC 2.8.1.1) from Mycobacterium FT tuberculosis (277 aa), FASTA scores: opt: 955, E(): FT 6.3e-56, (50.2% identity in 271 aa overlap); and FT Q50036|THTR_MYCLE|CYSA|CYSA3|ML2198 PUTATIVE THIOSULFATE FT SULFURTRANSFERASE from Mycobacterium leprae (277 aa), FASTA FT scores: opt: 931, E(): 2.5e-54, (48.9% identity in 276 aa FT overlap). Shows some similarity to MTCY339.19c (30.3% FT identity in 254 aa overlap). Contains PS00683 Rhodanese FT C-terminal signature. BELONGS TO THE RHODANESE FAMILY." FT /db_xref="GOA:Q7TWT6" FT /db_xref="HSSP:1E0C" FT /db_xref="InterPro:IPR001307" FT /db_xref="UniProtKB/Swiss-Prot:Q7TWT6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95403.1" FT /translation="MPLPADPSPTLSAYAHPERLVTADWLSAHMGAPGLAIVESDEDVL FT LYDVGHIPGAVKIDWHTDLNDPRVRDYINGEQFAELMDRKGIARDDTVVIYGDKSNWWA FT AYALWVFTLFGHADVRLLNGGRDLWLAERRETTLDVPTKTCTGYPVVQRNDAPIRAFRD FT DVLAILDAQPLIDVRSPEEYTGKRTHMPDYPEEGALRAGHIPTAVHIPWGKAADESGRF FT RSREELERLYDFINPDDQTVVYCRIGERSSHTWFVLTHLLGKADVRNYDGSWTEWGNAV FT RVPIVAGEEPGVVPVV" FT CDS 177343..177774 FT /transl_table=11 FT /gene="Mb3312" FT /locus_tag="Mb3312" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3312, -, len: 143 aa. Equivalent to Rv3284, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 143 aa overlap). Conserved hypothetical FT protein, with similarity to other bacterial hypothetical FT proteins e.g. Q9RXU0|DR0216 from Deinococcus radiodurans FT (147 aa), FASTA scores: opt: 425, E(): 9.1e-21, (46.55% FT identity in 146 aa overlap); BAB37094|ECS3671 from FT Escherichia coli strain O157:H7 (147 aa), FASTA scores: FT opt: 187, E(): 2.2e-05, (29.5% identity in 139 aa overlap); FT AAG57925|YGDK from Escherichia coli strain O157:H7 EDL933 FT (147 aa), FASTA scores: opt: 187, E(): 2.2e-05, (32.05% FT identity in 139 aa overlap); etc." FT /db_xref="HSSP:1NI7" FT /db_xref="InterPro:IPR003808" FT /db_xref="UniProtKB/Swiss-Prot:P67124" FT /protein_id="CAD95404.1" FT /translation="MTAPASLPAPLAEVVSDFAEVQGQDKLRLLLEFANELPALPSHLA FT ESAMEPVPECQSPLFLHVDASDPNRVRLHFSAPAEAPTTRGFASILAAGLDEQPAADIL FT AVPEDFYTELGLAALISPLRLRGMSAMLARIKRRLREAD" FT CDS 177882..179684 FT /transl_table=11 FT /gene="accA3" FT /locus_tag="Mb3313" FT /product="PROBABLE BIFUNCTIONAL PROTEIN FT ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE (ALPHA CHAIN) FT ACCA3: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN FT (BCCP)" FT /EC_number="6.3.4.14" FT /note="Mb3313, accA3, len: 600 aa. Equivalent to Rv3285, FT len: 600 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 600 aa overlap). Probable accA3, FT bifunctional protein acetyl-/propionyl-coenzyme A FT carboxylase, alpha chain (EC 6.3.4.14) (see citations FT below) equivalent to FT P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129 FT ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN from FT Mycobacterium leprae (598 aa), FASTA scores: opt: 3510, FT E(): 1.1e-196, (89.3% identity in 601 aa overlap). Also FT highly similar to other proteins e.g. P71122|ACCBC ACYL FT COENZYME A CARBOXYLASE from Corynebacterium glutamicum FT (Brevibacterium flavum) (591 aa), FASTA scores: opt: 2776, FT E(): 5.6e-154, (71.95% identity in 592 aa overlap); FT Q54119|BCPA2 BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER FT PROTEIN from Saccharopolyspora erythraea (Streptomyces FT erythraeus) (591 aa), FASTA scores: opt: 2723, E(): FT 6.7e-151, (70.5% identity in 590 aa overlap); Q54105|BCPA FT BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from FT Saccharopolyspora erythraea (Streptomyces erythraeus) (597 FT aa), FASTA scores: opt: 2721, E(): 8.9e-151, (70.05% FT identity in 594 aa overlap); Q9EWV4|2SCK31.20 PUTATIVE FT ACYL-COA CARBOXYLASE COMPLEX A SUBUNIT from Streptomyces FT coelicolor (590 aa), FASTA scores: opt: 2626, E(): FT 2.9e-145, (68.25% identity in 595 aa overlap); etc. FT Contains PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2, PS00188 Biotin-requiring enzymes attachment FT site. SIMILAR TO OTHER BIOTIN-DEPENDENT ENZYMES AND FT CARBAMOYL-PHOSPHATE SYNTHETASES." FT /db_xref="GOA:Q7TWT5" FT /db_xref="HSSP:1BNC" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/TrEMBL:Q7TWT5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95405.1" FT /translation="MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEP FT DAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQA FT VIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGL FT PIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQ FT VIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGA FT GTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPR FT GHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLI FT VHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEW FT NNTIEPFTDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPK FT PRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKD FT GTITGLAVEAGAAITQGTVLAEIK" FT CDS complement(179694..180479) FT /transl_table=11 FT /gene="sigF" FT /locus_tag="Mb3314c" FT /product="PROBABLE RNA POLYMERASE SIGMA FACTOR SIGF" FT /note="Mb3314c, sigF, len: 261 aa. Equivalent to Rv3286c, FT len: 261 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 261 aa overlap). Probable sigF, stress FT response/stationary phase RNA polymerase sigma factor (see FT citations below), similar to several Streptomyces RNA FT polymerase sigma factors e.g. Q9RPC8|SIGH from Streptomyces FT coelicolor A3(2) (354 aa), FASTA scores: opt: 869, E(): FT 1.1e-45, (51.15% identity in 258 aa overlap); Q9RIT0|SIG1 FT from Streptomyces coelicolor (361 aa), FASTA scores: opt: FT 869, E(): 1.1e-45, (51.15% identity in 258 aa overlap); FT Q9ADM4|2SC10A7.38c from Streptomyces coelicolor (318 aa), FT FASTA scores: opt: 776, E(): 4.6e-40, (48.75% identity in FT 240 aa overlap); P37971|RPOF_STRCO|SIGF|RPOX|2SCD60.01c FT from Streptomyces coelicolor (287 aa), FASTA scores: opt: FT 717, E(): 1.6e-36, (44.5% identity in 245 aa overlap); FT P37970|RPOF_STRAU|SIGF|RPOX from Streptomyces aureofaciens FT (297 aa); etc. Contains possible helix-turn-helix motif at FT aa 229-250 (+7.38 SD). SIMILAR TO THE SIGMA-70 FACTOR FT FAMILY. Seems expressed in stationary phase and under FT stress conditions in vitro (see citations below)." FT /db_xref="GOA:P96891" FT /db_xref="HSSP:1L0O" FT /db_xref="InterPro:IPR014322" FT /db_xref="UniProtKB/TrEMBL:P96891" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95406.1" FT /translation="MTARAAGGSASRANEYADVPEMFRELVGLPAGSPEFQRHRDKIVQ FT RCLPLADHIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGEVR FT RHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELGMDRAEVIEGLL FT AGSSYHTLSIDSGGGSDDDARAITDTLGDVDAGLDQIENREVLRPLLEALPERERTVLV FT LRFFDSMTQTQIAERVGISQMHVSRLLAKSLARLRDQLE" FT CDS complement(180476..180913) FT /transl_table=11 FT /gene="rsbW" FT /locus_tag="Mb3315c" FT /standard_name="usfX" FT /product="ANTI-SIGMA FACTOR RSBW (SIGMA NEGATIVE EFFECTOR)" FT /note="Mb3315c, rsbW, len: 145 aa. Equivalent to Rv3287c, FT len: 145 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 145 aa overlap). rsbW (alternate gene FT name: usfX), anti-sigma factor (see citations below), FT similar to Q49667|B1308_F3_89 from Mycobacterium leprae (75 FT aa), FASTA scores: opt: 308, E(): 2.5e-15, (72.2% identity FT in 72 aa overlap); Q9R3X8|PRS1|USHX|PRS PRS1 PROTEIN FT (ANTI-SIGMA FACTOR) from Streptomyces coelicolor (137 aa), FT FASTA scores: opt: 184, E(): 3.7e-06, (36.8% identity in FT 106 aa overlap); O50231 PUTATIVE SIGMA-B REGULATOR from FT Bacillus licheniformis (160 aa), FASTA scores: opt: 122, FT E(): 0.13, (23.9% identity in 92 aa overlap); and FT P17904|RSBW_BACSU ANTI-SIGMA B FACTOR (SIGMA-B NEGATIVE FT EFFECTOR RSBW) from Bacillus subtilis (160 aa), FASTA FT scores: opt: 108, E(): 1.3, (21.25% identity in 127 aa FT overlap). Equivalent to AAK47729 from Mycobacterium FT tuberculosis strain CDC1551 (145 aa) but longer 99 aa. FT INDUCTION BY HEAT SHOCK, SALT STRESS, OXIDATIVE STRESS, FT GLUCOSE LIMITATION AND OXYGEN LIMITATION. N-terminus FT shortened since first submission (previously 242 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7TWT4" FT /protein_id="CAD95407.1" FT /translation="MADSDLPTKGRQRGVRAVELNVAARLENLALLRTLVGAIGTFEDL FT DFDAVADLRLAVDEVCTRLIRSALPDATLRLVVDPRKDEVVVEASAACDTHDVVAPGSF FT SWHVLTALADDVQTFHDGRQPDVAGSVFGITLTARRAASSR" FT CDS complement(181111..181524) FT /transl_table=11 FT /gene="usfY" FT /locus_tag="Mb3316c" FT /product="PUTATIVE PROTEIN USFY" FT /note="Mb3316c, usfY, len: 137 aa. Equivalent to Rv3288c, FT len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 137 aa overlap). usfY, putative protein FT (see citation below). Has no significant homologues. May FT not be contranscribed with the usfX and sigF proteins." FT /db_xref="UniProtKB/TrEMBL:P96893" FT /protein_id="CAD95408.1" FT /translation="MGQIPPQPVRRVLPLMVVPGNGQKWRNRTETEEAMGDTYRDPVDH FT LRTTRPLAGESLIDVVHWPGYLLIVAGVVGGVGALAAFGTGHHAEGMTFGVVAIVVTVV FT GLAWLAFEHRRIRKIADRWYTEHPEVRRQRLAG" FT CDS complement(181559..181936) FT /transl_table=11 FT /gene="Mb3317c" FT /locus_tag="Mb3317c" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /note="Mb3317c, -, len: 125 aa. Equivalent to Rv3289c, len: FT 125 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 125 aa overlap). Possible transmembrane FT protein, showing slight similarity to other membrane FT proteins or glycoproteins." FT /db_xref="GOA:Q7TWT3" FT /db_xref="UniProtKB/TrEMBL:Q7TWT3" FT /protein_id="CAD95409.1" FT /translation="MHEVGGPSRGDRLGRDDSEVHSAIRFAVVAAVVGVGFLIMGALLV FT STCSGVDTAACGPPQRILLALGGPLILCAAGLWAFLRTYRVWRAEGTWWGWHGAGWFLL FT TLMVLTLCIGVPPIAGPVMAP" FT CDS complement(181970..183319) FT /transl_table=11 FT /gene="lat" FT /locus_tag="Mb3318c" FT /product="PROBABLE L-LYSINE-EPSILON AMINOTRANSFERASE LAT FT (L-LYSINE AMINOTRANSFERASE) (LYSINE 6-AMINOTRANSFERASE)" FT /EC_number="2.6.1.36" FT /note="Mb3318c, lat, len: 449 aa. Equivalent to Rv3290c, FT len: 449 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 449 aa overlap). Probable lat, FT lysine-epsilon aminotransferase (EC 2.6.1.36), similar to FT Q05174|LAT_NOCLA from Nocardia lactamdurans (450 aa), FASTA FT scores: opt: 1702, E(): 1.1e-99, (60.35% identity in 439 aa FT overlap); and Q01767|Q53823|LAT_STRCL from Streptomyces FT clavuligerus (457 aa), FASTA scores: opt: 1676, E(): FT 4.9e-98, (60.15% identity in 434 aa overlap). Also some FT similarity to 4-AMINOBUTYRATE AMINOTRANSFERASE PROTEINS FT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASES). BELONGS TO FT CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE." FT /db_xref="GOA:P63510" FT /db_xref="HSSP:1QJ3" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P63510" FT /protein_id="CAD95410.1" FT /translation="MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGS FT YLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMA FT RFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHL FT RGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQAR FT AAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTG FT TAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVR FT ARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADR FT DELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT" FT CDS complement(183370..183822) FT /transl_table=11 FT /gene="Mb3319c" FT /locus_tag="Mb3319c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY ASNC-FAMILY)" FT /note="Mb3319c, -, len: 150 aa. Equivalent to Rv3291c, len: FT 150 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 150 aa overlap). Probable FT transcriptional regulator asnC-family, similar to other FT regulatory proteins e.g. Q9RKY4|SC6D7.14 from Streptomyces FT coelicolor (165 aa), FASTA scores: opt: 503, E(): 9.1e-26, FT (50.35% identity in 143 aa overlap); Q9KYP0|SCD69.13 from FT Streptomyces coelicolor (167 aa), FASTA scores: opt: 310, FT E(): 2.7e-13, (37.2% identity in 129 aa overlap); FT BAB50701|MLL3910 from Rhizobium loti (Mesorhizobium loti) FT (152 aa), FASTA scores: opt: 282, E(): 1.6e-11, (39.55% FT identity in 129 aa overlap); O87635|LRP_KLEAE from FT Klebsiella aerogenes (163 aa), FASTA scores: opt: 279, E(): FT 2.5e-11, (38.1% identity in 147 aa overlap); etc. Contains FT helix-turn-helix motif at aa 22-43 (+3.94 SD). COULD BELONG FT TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7TWT2" FT /db_xref="InterPro:IPR019888" FT /db_xref="UniProtKB/TrEMBL:Q7TWT2" FT /protein_id="CAD95411.1" FT /translation="MNEALDDIDRILVRELAADGRVTLSELATRAGLSVSAVQSRVRRL FT ESRGVVQGYSARINPEAVGHLLSAFVAITPLDPSQPDDAPARLEHIEEVESCYSVAGEE FT SYVLLVRVASARALEDLLQRIRTTANVRTRSTIILNTFYSDRQHIP" FT CDS 183853..185100 FT /transl_table=11 FT /gene="Mb3320" FT /locus_tag="Mb3320" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3320, -, len: 415 aa. Equivalent to Rv3292, len: FT 415 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 415 aa overlap). Conserved hypothetical FT protein, similar to P76097|YDCJ_ECOLI|B1423 HYPOTHETICAL FT 51.0 KDA PROTEIN from Escherichia coli strain K12 (447 aa), FT FASTA scores: opt: 747, E(): 5.6e-39, (38.55% identity in FT 449 aa overlap); BAB35451|ECS2028 HYPOTHETICAL 51.0 KDA FT PROTEIN from Escherichia coli strain O157:H7 (447 aa), FT FASTA scores: opt: 744, E(): 8.6e-39, (38.3% identity in FT 449 aa overlap); AAG56352|Z2297 PROTEIN from Escherichia FT coli O157:H7 EDL933 (212 aa), FASTA scores: opt: 454, E(): FT 4.6e-21, (41.75% identity in 206 aa overlap); and similar FT in part with Q49664|B1308_C1_136 from Mycobacterium leprae FT (71 aa), FASTA scores: opt: 305, E(): 3.2e-12, (70.0% FT identity in 70 aa overlap)." FT /db_xref="InterPro:IPR009770" FT /db_xref="UniProtKB/Swiss-Prot:P65066" FT /protein_id="CAD95412.1" FT /translation="MSRSKRLQTGQLRARFAAGLSAMYAAEVPAYGTLVEVCAQVNSDY FT LTRHRRAERLGSLQRVTAERHGAIRVGNPAELAAVADLFAAFGMLPVGYYDLRTAESPI FT PVVSTAFRPIDANELAHNPFRVFTSMLAIEDRRYFDADLRTRVQTFLARRQLFDPALLA FT QARAIAADGGCDADDAPAFVAAAVAAFALSREPVEKSWYDELSRVSAVAADIAGVGSTH FT INHLTPRVLDIDDLYRRMTERGITMIDTIQGPPRTDGPDVLLRQTSFRALAEPRMFRDE FT DGTVTPGILRVRFGEVEARGVALTPRGRERYEAAMAAADPAAVWATHFPSTDAEMAAQG FT LAYYRGGDPSAPIVYEDFLPASAAGIFRSNLDRDSQTGDGPDDAGYNVDWLAGAIGRHI FT HDPYALYDALAQEERR" FT CDS 185127..186611 FT /transl_table=11 FT /gene="pcd" FT /locus_tag="Mb3321" FT /product="PROBABLE PIPERIDEINE-6-CARBOXILIC ACID FT DEHYDROGENASE PCD (PIPERIDEINE-6-CARBOXYLATE FT DEHYDROGENASE)" FT /EC_number="1.5.-.-" FT /note="Mb3321, pcd, len: 494 aa. Equivalent to Rv3293, len: FT 494 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 494 aa overlap). Probable pcd, FT piperideine-6-carboxylic acid dehydrogenase (EC 1.5.-.-), FT highly similar to others e.g. O85725|PCD SEMIALDEHYDE FT DEHYDROGENASE from Streptomyces clavuligerus (512 aa), FT FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity in FT 496 aa overlap) (see first citation below); Q9I4U7|PA1027 FT PROBABLE ALDEHYDE DEHYDROGENASE from Pseudomonas aeruginosa FT (529 aa), FASTA scores: opt: 1984, E(): 1.4e-107, (64.5% FT identity in 493 aa overlap); BAB49892|MLL2867 ALDEHYDE FT DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (504 FT aa), FASTA scores: opt: 1964, E(): 2e-106, (62.8% identity FT in 476 aa overlap); Q9A8Y1|CC1216 ALDEHYDE DEHYDROGENASE FT from Caulobacter crescentus (507 aa), FASTA scores: opt: FT 1909, E(): 3.1e-103, (59.95% identity in 497 aa overlap); FT O54199|PCD PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE from FT Streptomyces clavuligerus (496 aa), FASTA scores: opt: FT 1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap); and FT Q9F1U8|PCD PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE from FT 'Flavobacterium' lutescens (510 aa), FASTA scores: opt: FT 1656, E(): 1.4e-88, (54.05% identity in 481 aa overlap) FT (see second citation below); etc. Contains PS00687 Aldehyde FT dehydrogenases glutamic acid active site. Note that ORF FT Rv3290c seems to encoded the putative lat enzyme. FT Previously known as aldB." FT /db_xref="GOA:Q7TWT1" FT /db_xref="HSSP:1BXS" FT /db_xref="InterPro:IPR016162" FT /db_xref="UniProtKB/TrEMBL:Q7TWT1" FT /protein_id="CAD95413.1" FT /translation="MLEACQAIGVTAALGEPGEHSLPASTPITGDVLFSIAPTTPEQAD FT HAIAAAAATFTAWRSTPAPVRGALVARLGELLTAHQQDLATLVTVEVGKITAEARGEVQ FT EMIDVCQFSVGLSRQLYGRTIASERAGHRLLETWHPLGVVGVITAFNFPVAVWAWNTAV FT ALVCGDTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLVDDPR FT VALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLELAVRCIVFAAAGT FT AGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDPSAPDTLVGPLIHEAAYRDMVAA FT LERARTDGGEVIGGDRREVGSPGAYYVAPAVVRMPSQTAIVATETFAPILYVLTYDDLD FT EAIALNNAVPQGLSSSIFTTDLREAEHFLDQSDCGIANVNIGTSGAEIGGAFGGEKQTG FT GGRESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG" FT CDS complement(186711..187520) FT /transl_table=11 FT /gene="Mb3322c" FT /locus_tag="Mb3322c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3322c, -, len: 269 aa. Equivalent to Rv3294c, len: FT 269 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 269 aa overlap). Conserved hypothetical FT protein, similar to several conserved hypothetical proteins FT from Mycobacterium tuberculosis: O07781|Rv0597c (411 aa), FT FASTA scores: opt: 682, E(): 3.6e-37, (44.85% identity in FT 243 aa overlap); O53329|Rv3179 (454 aa), FASTA scores: opt: FT 561, E(): 3.3e-29, (42.20% identity in 218 aa overlap); FT Q10849|YK08_MYCTU|Rv2008c (441 aa), FASTA scores: opt: 194, FT E(): 3.9e-05, (30.10% identity in 239 aa overlap). Also FT some similarity with proteins from other organisms. Replace FT previous Rv3294 on opposite strand." FT /db_xref="UniProtKB/TrEMBL:Q7TWT0" FT /protein_id="CAD95414.1" FT /translation="MGLPRRPCCDTTGSARYRESVRRYPRIGEDSAAYRRRLCRESAKA FT RNVDRVVKRDAADVSNLQRIADLPRLIRLLAARSASELNLSSLATDAEIPVRTLPPYLD FT LLETLYLIDRIPAWSTNLSKRVVDRPKVLLLDSGLAARLVNVSPTGAGPHANPNAAGAI FT IETFVIAELRRQLGWSQQAPRLFHYRDRDGAEVDLILETADGLIAAIEIKSAATLRGRD FT TRSISRLRDKVGARFAGGVILHTGPQAQPFGDRLAAVPIDILWSPSG" FT CDS 187591..188256 FT /transl_table=11 FT /gene="Mb3323" FT /locus_tag="Mb3323" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /note="Mb3323, -, len: 221 aa. Equivalent to Rv3295, len: FT 221 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 221 aa overlap). Probable FT transcriptional regulator tetR-family, equivalent to FT Q9CCL4|ML0717 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL FT REGULATOR from Mycobacterium leprae (223 aa), FASTA scores: FT opt: 1260, E(): 7.2e-75, (85.45% identity in 220 aa FT overlap). Also highly similar to other streptomyces FT regulators e.g. Q9RD77|SCF43.11 from Streptomyces FT coelicolor (205 aa), FASTA scores: opt: 442, E(): 9.8e-22, FT (38.6% identity in 202 aa overlap); Q9RKY8|SC6D7.09 from FT Streptomyces coelicolor (220 aa), FASTA scores: opt: 215, FT E(): 5.9e-07, (31.85% identity in 135 aa overlap); FT Q9L0U5|SCD35.06 from Streptomyces coelicolor (240 aa), FT FASTA scores: opt: 214, E(): 7.4e-07, (28.2% identity in FT 156 aa overlap); etc. SIMILAR TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS. Contains potential FT helix-turn-helix motif at aa 33-54 (+4.42 SD)." FT /db_xref="GOA:Q7TWS9" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7TWS9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD95415.1" FT /translation="MATARRRLSPQDRRAELLALGAEVFGKRPYDEVRIDEIAERAGVS FT RALMYHYFPDKRAFFAAVVKDEADRLYAATNKAPAPGMTMFEEIRTGVLAYMAYHQQNP FT EAAWAAYVGLGRSDPVLLGIDDEAKNRQMEHIMSRIAEVVSGIDRDNTLDPEVERDLRV FT IIHGWLAFTFELCRQRIMDPSTDAERLADACAHALLDAISRLPQIPAELADAMATARM" FT CDS 188300..192841 FT /transl_table=11 FT /gene="lhr" FT /locus_tag="Mb3324" FT /product="PROBABLE ATP-DEPENDENT HELICASE LHR (LARGE FT HELICASE-RELATED PROTEIN)" FT /EC_number="3.6.1.-" FT /note="Mb3324, lhr, len: 1513 aa. Equivalent to Rv3296, FT len: 1512 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 1512 aa overlap). Probable lhr, FT ATP-dependent helicase (EC 3.6.1.-), similar to others e.g. FT P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain K12 FT (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.55% FT identity in 1569 aa overlap); AAG56642|LHR from Escherichia FT coli stain O157:H7 EDL933 (1538 aa), FASTA scores: opt: FT 2930, E(): 1.5e-159, (47.6% identity in 1561 aa overlap); FT O86821|SC7C7.16c from Streptomyces coelicolor (1690 aa), FT FASTA scores: opt: 2919, E(): 7e-159, (53.55% identity in FT 1703 aa overlap); Q9HYW9|PA3272 from Pseudomonas aeruginosa FT (1448 aa), FASTA scores: opt: 907, E(): 6.2e-44, (35.85% FT identity in 1512 aa overlap); etc. SIMILAR TO DEAD/DEAH BOX FT HELICASE FAMILY AND TO HELICASE C-TERMINAL DOMAIN. Contains FT PS00017 ATP/GTP-binding site motif A and possible FT helix-turn-helix motif." FT /db_xref="GOA:Q7TWS8" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TWS8" FT /protein_id="CAD95416.1" FT /translation="MRFAQPSALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNTL FT VIAPTGSGKTLAAFLWALDSLAGSEPMSERPAATRVLYVSPLKALAVDVERNLRTPLAG FT LTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQPPDVLITTPESLFLMLTSAARQTL FT TGVQTVIIDEIHAIAATKRGAHLALSLERLDDLSSRRRAQRIGLSATVRPPEELARFLS FT GQSPTTIVAPPAAKTVELSVQVPVPDMANLTDNTIWPDVEARLVDLIESHNSTIVFANS FT RRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAPAHIMGSGQTFGAPPVLARAHHGS FT ISKEQRAVVEEDLKRGQLKAVVATSSLELGIDMGAVDLVIQVQAPPSVASGLQRIGRAG FT HQVGEISRGVLFPKHRTDLLGCAVSVQRMLAGEIETMRVPANPLDILAQHTVAAAALEP FT LDADAWFDTVRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTAR FT PGAQRLAVTSGGAIPDRGLFAVYLATERPSRVGELDEEMVYESRPGDVISLGATSWRIT FT EITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAALGALTGELAALDRTAFGTRCAGL FT GFDDYATDNLWRLLDDQRTATAVVPTDSTLLVERFRDELGDWRVILHSPYGLRVHGPLA FT LAVGRRLRDRYGIDEKPTASDNGIMVRLPDTVSAGEDSPPGAELFVFDADEIDPIVTTE FT VAGSALFASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEVARKYPDFPIVLETV FT RECLQNVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLFGYVGAFMYEGDTPLA FT ERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQLQHLAADRVARDAEGVADLLR FT LLGPLTEDEIAARAGAPEVSGWLDGLRAAKRALVVSFAGRSWWVAVEDMGRLRDGVGAA FT VPVGLPASFTEAVADPLGELLGRYARTHTPFTTAAAAARFGLGLRVTADVLGRLASDGR FT LVRGEFVAAAEGSAGGEQWCDAEVLRILRRRSLAALRAQAEPVSTAAYGRFLPAWQHVS FT AGNSGIDGLAAVIDQLAGVRIPASAIEPLVLAPRIRDYSPAMLDELLASGDVTWSGAGS FT ISGSDGWIALHPADSAPMTLAEPAEIDFTDAHRAILASLGTGGAYFFRQLTHDGLTEAE FT LKAALWELIWAGRVTGDTFAPVRAVLGGAGTRKRAAPAHGGHRPPRLSRYRLTHAQARN FT ADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGVLTKDAVAAEGVAGGFATLYKVLS FT AFEDAGRCQRGYFIESLGGAQFAVASTVDRLRSYLDGVDPEQPDYHAVVLAAADPANPY FT GAALPWPASSADGTARPGRKAGALVVLVDGELAWFLERGGRSLLTFTDDPEANHAAAIG FT LADLVTAGRVASILVERADGMPVLQPGGRASAALTALLAAGFVRTPRGLRRR" FT CDS 192845..193612 FT /transl_table=11 FT /gene="nei" FT /locus_tag="Mb3325" FT /product="PROBABLE ENDONUCLEASE VIII NEI" FT /EC_number="3.2.-.-" FT /note="Mb3325, nei, len: 255 aa. Equivalent to Rv3297, len: FT 255 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 255 aa overlap). Probable nei, FT endonuclease VIII (EC 3.2.-.-), similar to others e.g. FT O86820|END8_STRCO|NEI|SC7C7.15c from Streptomyces FT coelicolor (276 aa), FASTA scores: opt: 770, E(): 1.2e-42, FT (50.35% identity in 268 aa overlap); FT P50465|END8_ECOLI|NEI|B0714 from Escherichia coli strain FT K12 (262 aa), FASTA scores: opt: 310, E(): 6.3e-13, (28.1% FT identity in 267 aa overlap); AAG55037|NEI from Escherichia FT coli strain O157:H7 EDL933 (263 aa), FASTA scores: opt: FT 301, E(): 2.4e-12, (27.7% identity in 267 aa overlap); etc. FT BELONGS TO THE FPG FAMILY." FT /db_xref="GOA:P64157" FT /db_xref="HSSP:1K3X" FT /db_xref="InterPro:IPR012319" FT /db_xref="UniProtKB/Swiss-Prot:P64157" FT /protein_id="CAD95417.1" FT /translation="MPEGDTVWHTAATLRRHLAGRTLTRCDIRVPRFAAVDLTGEVVDE FT VISRGKHLFIRTGTASIHSHLQMDGSWRVGNRPVRVDHRARIILEANQQEQAIRVVGVD FT LGLLEVIDRHNDGAVVAHLGPDLLADDWDPQRAAANLIVAPDRPIAEALLDQRVLAGIG FT NVYCNELCFVSGVLPTAPVSAVADPRRLVTRARDMLWVNRFRWNRCTTGDTRAGRRLWV FT YGRAGQGCRRCGTLIAYDTTDERVRYWCPACQR" FT CDS complement(193635..194549) FT /transl_table=11 FT /gene="lpqC" FT /locus_tag="Mb3326c" FT /product="POSSIBLE ESTERASE LIPOPROTEIN LPQC" FT /EC_number="3.1.-.-" FT /note="Mb3326c, lpqC, len: 304 aa. Equivalent to Rv3298c, FT len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 304 aa overlap). Possible lpqC, FT esterase lipoprotein (EC 3.1.-.-), equivalent to FT Q9CCL5|LPQC|ML0715 PUTATIVE SECRETED HYDROLASE from FT Mycobacterium leprae (304 aa), FASTA scores: opt: 1543, FT E(): 1.3e-87, (71.6% identity in 303 aa overlap); and FT Q49658|B1308_F2_43 TUBULIN FAMILY PROTEIN from FT Mycobacterium leprae (302 aa), FASTA scores: opt: 1541, FT E(): 1.7e-87, (72.0% identity in 300 aa overlap). Also FT similar to Q9I5Z3|PA0543 HYPOTHETICAL PROTEIN from FT Pseudomonas aeruginosa (322 aa), FASTA scores: opt: 439, FT E(): 8.9e-20, (32.3% identity in 319 aa overlap); FT Q9F2K9|SCH63.19c PUTATIVE SECRETED PROTEIN from FT Streptomyces coelicolor (348 aa), FASTA scores: opt: 394, FT E(): 5.5e-17, (30.25% identity in 334 aa overlap); etc. And FT similar to O86367|LPQP|Rv0671|MTCI376.03c from FT Mycobacterium tuberculosis strain H37Rv (280 aa), FASTA FT scores: opt: 519, E(): 9.8e-25, (39.25% identity in 275 aa FT overlap). Probably lipoprotein, esterase membrane-bound, FT with 18 aa signal sequence as it contains appropriately FT positioned (PS00013) Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:Q7TWS7" FT /db_xref="InterPro:IPR017975" FT /db_xref="UniProtKB/TrEMBL:Q7TWS7" FT /protein_id="CAD95418.1" FT /translation="MPWARMLSLIVLMVCLAGCGGDQLLARHASSVATFQFGGLTRSYR FT LHVPPAEPSGLVISLHGGGGTGAGQEALTDFDAVADAADLLVVYPDGYDKSWADGRGAS FT PADRRHLDDVGFLVALAAKLVHDFDIAPGHVFATGMSNGGFMSNRLACDRADIFAAVAP FT VAGTLGVGVTCNPSRPVSVLEAHGTADPLVPFNGGAVRGRGGLSHSISVASLVDRWRAV FT DGCQGDPSAAELPDVGDGTMVHLFDSSSCAAGTEVISYQIDNGGHTWPGGRQYLPKAVI FT GATTRAFDGSQVIAQFFATHGRD" FT CDS complement(194576..197488) FT /transl_table=11 FT /gene="atsB" FT /locus_tag="Mb3327c" FT /product="PROBABLE ARYLSULFATASE ATSB (ARYL-SULFATE FT SULPHOHYDROLASE) (SULFATASE)" FT /EC_number="3.1.6.1" FT /note="Mb3327c, atsB, len: 970 aa. Equivalent to Rv3299c, FT len: 970 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 970 aa overlap). Probable atsB, FT arylsulfatase (EC 3.1.6.1), similar to FT P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from FT Pseudomonas aeruginosa (535 aa), FASTA scores: opt: 645, FT E(): 5.8e-31, (32.0% identity in 550 aa overlap); FT Q9L4Y2|ATSA from Klebsiella pneumoniae (577 aa), FASTA FT scores: opt: 504, E(): 1.7e-22, (26.3% identity in 566 aa FT overlap); and P20713|ATSA|ARS_KLEAE (precursor) from FT Klebsiella pneumoniae (464 aa), FASTA scores: opt: 502, FT E(): 1.8e-22, (26.85% identity in 451 aa overlap). Also FT similar to Mycobacterium tuberculosis proteins FT O06776|MTI376.13c|ATSD|Rv0663 (787 aa) (43.6% identity in FT 796 aa overlap) and P95059|MTCY210.30|ATSA|R0711 (787 aa) FT (38.4% identity in 797 aa overlap). Equivalent to AAK47741 FT from Mycobacterium tuberculosis strain CDC1551 (992 aa) but FT shorter 22 aa. Contains PS00523 Sulfatases signature 1 and FT PS01095 Chitinases family 18 active site signature. BELONGS FT TO THE SULFATASE FAMILY." FT /db_xref="GOA:Q7TWS6" FT /db_xref="HSSP:1E33" FT /db_xref="InterPro:IPR001579" FT /db_xref="UniProtKB/TrEMBL:Q7TWS6" FT /protein_id="CAD95419.1" FT /translation="MMSEDNALVLVAGYQDLDSARHDFQTLVDAAKDKSIPLQGAVLIG FT KDAEGSPVLVDTGNRLGRRGAAWGAGVGLAIGLFSPALLASAALGAATGALAGTFAHHR FT IKTGLADKIGQALAAGRAVVIAVTEAQGRLEAGQALASSPMKSVAELSRSTLRSLGAAL FT REAMGKFNPDRTRLPLPQRRFGGVVGRTMAESVGDWSIVPSPFPPDDAPNVLIVLIDDA FT GFGGPDTFGGAIRTPTLSRLAQNGLIYNRFHVTAVCSPTRAALLTGRNHHRVGFGSVCE FT FPGPYPGYSAVRPRSCAALPRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNWPLGWGF FT DHFWGFPSGAAGQYDPIISQDNSVIGIPEGSGEDGRPYYFPDDLTDKAIEWLHTVRAQN FT ATKPWMLYYATGATHAPHHVFKEWADKYRGEFDDGWDVYRQKTFERQKRLGIIPPDAEL FT TERPDLFPAWDSMSEAQKRLFARQMEVFAGFSENADWNVGRLLDAIEDLGESDNTLVFY FT IWGDNGASMEGTNTGSFNEMTFLNGLDLDAERQLELIEQYGGIAALGDEFTAPHFASAW FT AHASNTPLQWGKQMASHLGGTRDPLVVAWPARIRPDGRVRSQFTHCIDIAPTVLAAIGL FT PEPTHVDGFEQEPMDGTSFVRTFDDAEAEDRHTVQYFENFGSRAIYKDGWWACARLDKA FT PWDLSPETMRRFAPGTYDPDQDVWELYYLPDDFSQAKNLAAEHPDKVAELTQLWWQEAE FT RNRVLPLLGGLAVMFGDLPPLPTTARFSFKGDVQNIQRGMVPRICGRSYAIEARLHIPD FT GGAQGVIVANADFMGGFALWVDEQRHLHHTYSFLGVETYRQVSSEPLPTGDVTVRMLFD FT SHQPVAASGGRVTLWADDRLIGEGELPQTVPLAFTSYAGMDIGRDNGLVVDRGYEDKAP FT YAFTGTVTEVIFDLKPVHPEAARALHEHASVQAVGQGAAG" FT CDS complement(197508..198425) FT /transl_table=11 FT /gene="Mb3328c" FT /locus_tag="Mb3328c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3328c, -, len: 305 aa. Equivalent to Rv3300c, len: FT 305 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 305 aa overlap). Conserved hypothetical FT protein, similar to various proteins (notably pseudoridine FT synthase family proteins) e.g. Q9RJ76|SCI41.08 PUTATIVE FT RIBOSOMAL PSEUDOURIDINE SYNTHASE from Streptomyces FT coelicolor (324 aa), FASTA scores: opt: 876, E(): 4.5e-48, FT (52.1% identity in 313 aa overlap); Q9I272|PA2043 FT HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa), FT FASTA scores: opt: 676, E(): 1.8e-35, (42.55% identity in FT 268 aa overlap); Q9JZW8|NMB0867 YABO/YCEC/SFHB FAMILY FT PROTEIN from Neisseria meningitidis (serogroup B) (307 aa), FT FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in FT 282 aa overlap); Q9JUY2|NMA1085 HYPOTHETICAL PROTEIN from FT Neisseria meningitidis (serogroup A) (307 aa), FASTA FT scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa FT overlap); Q12362|RIB2_YEAST|RIB2|YOL066C DRAP DEAMINASE FT (PSEUDOURIDINE SYNTHASE FAMILY PROTEIN) from Saccharomyces FT cerevisiae (Baker's yeast) (591 aa), FASTA scores: opt: FT 338, E(): 6.9e-14, (32.95% identity in 246 aa overlap); FT Q9RTS2|DR1684 PUTATIVE PSEUDOURIDINE SYNTHASE from FT Deinococcus radiodurans (321 aa), FASTA scores: opt: 319, FT E(): 6.5e-13, (32.75% identity in 235 aa overlap); etc. FT Also similar to Mycobacterium tuberculosis hypothetical FT protein Q10786|Y04P_MYCTU|MTCY48.25c|Rv1540|MT1592 (308 aa) FT (28.8% identity in 299 aa overlap)." FT /db_xref="GOA:Q7TWS5" FT /db_xref="InterPro:IPR006224" FT /db_xref="UniProtKB/TrEMBL:Q7TWS5" FT /protein_id="CAD95420.1" FT /translation="MALRPEDRLLSVHDVLGPVRVRLLGGSVLAELTARFGVAARAKVL FT AGEVVDNDGAVVDSGTVLPPGSVVHLYRDLPDEVPVPFDVPVLHQDADIVVVDKPHFLA FT TMPRGRHVAQTALVRLRRELGLPELSPAHRLDRLTAGVLLFTTRREVRGSYQTMFARGL FT VRKTYLARAPVAPGLALPRLVRSRIVKRRGHLQAVCEPGVPNAETLVERIARDGLYRLT FT PTTGRTHQLRVHMAALGIPIMGDPLYPNVISVAAHDFSTPLQLLAQRIEFDDPLTGSHR FT EFASTRTLTGATLPTWSAAADCRP" FT CDS complement(198437..199102) FT /transl_table=11 FT /gene="phoY1" FT /locus_tag="Mb3329c" FT /product="PROBABLE PHOSPHATE-TRANSPORT SYSTEM FT TRANSCRIPTIONAL REGULATORY PROTEIN PHOU HOMOLOG 1 PHOY1" FT /note="Mb3329c, phoY1, len: 221 aa. Equivalent to Rv3301c, FT len: 221 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 221 aa overlap). Probable phoY1, FT phosphate-transport system regulatory protein, highly FT similar to Q50047|phoY|PHOU1|PHOY1|ML2188 PHOSPHATE FT TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 1 from Mycobacterium FT leprae (222 aa), FASTA scores: opt: 929, E(): 7.8e-51, FT (61.45% identity in 218 aa overlap). Also highly similar to FT Q9FCE2|2SCD46.42c PUTATIVE REGULATORY PROTEIN (FRAGMENT) FT from Streptomyces coelicolor (123 aa), FASTA scores: opt: FT 324, E(): 1.8e-13, (43.65% identity in 103 aa overlap); FT Q9L0R3|SCD8A.01c PUTATIVE PHOSPHATE TRANSPORT SYSTEM FT REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor FT (139 aa), FASTA scores: opt: 309, E(): 1.7e-12, (36.7% FT identity in 139 aa overlap); Q52989|PHOU_RHIME PHOSPHATE FT TRANSPORT SYSTEM PROTEIN from Rhizobium meliloti FT (Sinorhizobium meliloti) (237 aa), FASTA scores: opt: 292, FT E(): 3.1e-11, (26.3% identity in 213 aa overlap); etc. And FT highly similar to Mycobacterium tuberculosis FT O53833|PHU2_MYCTU|MTV043_13c|PHOU2|PHOY2|Rv0821c|MT0843 FT PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (213 aa) FT (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FT FAMILY." FT /db_xref="GOA:P65719" FT /db_xref="InterPro:IPR008170" FT /db_xref="UniProtKB/Swiss-Prot:P65719" FT /protein_id="CAD95421.1" FT /translation="MRTVYHQRLTELAGRLGEMCSLAGIAMKRATQALLEADIGAAEQV FT IRDHERIVAMRAQVEKEAFALLALQHPVAGELREIFSAVQIIADTERMGALAVHIAKIT FT RREYPNQVLPEEVRNCFADMAKVAIALGDSARQVLVNRDPQEAAQLHDRDDAMDDLHRH FT LLSVLIDREWRHGVRVGVETALLGRFFERFADHAVEVGRRVIFMVTGVLPTEDEISTY" FT CDS complement(199210..200967) FT /transl_table=11 FT /gene="glpD2" FT /locus_tag="Mb3330c" FT /product="PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE FT GLPD2" FT /EC_number="1.1.99.5" FT /note="Mb3330c, glpD2, len: 585 aa. Equivalent to Rv3302c, FT len: 585 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 585 aa overlap). Probable glpd2, FT glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), FT equivalent to P53435|GLPD_MYCLE|ML0713|L308_C1_179 FT GLYCEROL-3-PHOSPHATE DEHYDROGENASE (EC 1.1.99.5) from FT Mycobacterium leprae (585 aa), FASTA scores: opt: 3489, FT E(): 2.2e-198, (90.75% identity in 584 aa overlap). Also FT highly similar to many e.g. Q9L0I3|SCD63.06 from FT Streptomyces coelicolor (568 aa), FASTA scores: opt: 2203, FT E(): 1.6e-122, (59.95% identity in 564 aa overlap); FT Q9RVK8|DR1019 from Deinococcus radiodurans (522 aa), FASTA FT scores: opt: 949, E(): 1.4e-48, (37.0% identity in 538 aa FT overlap); BAB53412|MLR7270 from Rhizobium loti FT (Mesorhizobium loti) (505 aa), FASTA scores: opt: 861, E(): FT 2.2e-43, (37.3% identity in 488 aa overlap); FT P18158|GLPD_BACSU from B. subtilis (555 aa), FASTA scores: FT opt: 768, E(): 7.2e-38, (32.85% identity in 484 aa FT overlap); etc. Also similar to Mycobacterium tuberculosis FT protein Q10502|GLPD_MYCTU|MTCY427_31c|Rv2249c FT GLYCEROL-3-PHOSPHATE DEHYDROGENASE (516 aa), FASTA scores: FT opt: 843, E(): 2.6e-42, (36.5% identity in 515 aa overlap). FT Contains PS00978 FAD-dependent glycerol-3-phosphate FT dehydrogenase signature 2. COFACTOR: FAD (BY SIMILARITY). FT BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE FT DEHYDROGENASE FAMILY." FT /db_xref="GOA:P64185" FT /db_xref="InterPro:IPR006076" FT /db_xref="UniProtKB/Swiss-Prot:P64185" FT /protein_id="CAD95422.1" FT /translation="MSNPIQAPDGGQGWPAAALGPAQRAVAWKRLGTEQFDVVVIGGGV FT VGSGCALDAATRGLKVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVREALYERE FT LSLTTLAPHLVKPLPFLFPLTKRWWERPYIAAGIFLYDRLGGAKSVPAQRHFTRAGALR FT LSPGLKRSSLIGGIRYYDTVVDDARHTMTVARTAAHYGAVVRCSTQVVALLREGDRVIG FT VGVRDSENGAVAEVRGHVVVNATGVWTDEIQALSKQRGRFQVRASKGVHVVVPRDRIVS FT DVAMILRTEKSVMFVIPWGSHWIIGTTDTDWNLDLAHPAATKADIDYILGTVNAVLATP FT LTHADIDGVYAGLRPLLAGESDDTSKLSREHAVAVPAAGLVAIAGGKYTTYRVMAADAI FT DAAVQFIPARVAPSITEKVSLLGADGYFALVNQAEHVGALQGLHPYRVRHLLDRYGSLI FT SDVLAMAASDPSLLSPITEAPGYLKVEAAYAAAAEGALHLEDILARRMRISIEYPHRGV FT DCAREVAEVVAPVLGWTAADIDREVANYMARVEAEVLSQAQPDDVSADMLRASAPEARA FT EILEPVPLD" FT CDS complement(201048..202463) FT /transl_table=11 FT /gene="lpdA" FT /locus_tag="Mb3331c" FT /product="PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA FT (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) FT (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE)" FT /EC_number="1.8.1.4" FT /note="Mb3331c, lpdA, len: 471 aa. Equivalent to Rv3303c, FT len: 493 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 471 aa overlap). Probable lpdA, FT dihydrolipoamide dehydrogenase (EC 1.8.1.4), similar to FT other e.g. Q9EWV3|2SCK31.22c PUTATIVE OXIDOREDUCTASE from FT Streptomyces coelicolor (475 aa), FASTA scores: opt: 1420, FT E(): 2.4e-77, (54.9% identity in 471 aa overlap); FT Q9A7J2|CC1731 LIPOAMIDE DEHYDROGENASE (E3 FT COMPONENT,PYRUVATE DEHYDROGENASE COMPLEX) from Caulobacter FT crescentus (466 aa), FASTA scores: opt: 696, E(): 3.6e-34, FT (29.6% identity in 463 aa overlap); Q04829|LPD|DLDH_HALVO FT DIHYDROLIPOAMIDE DEHYDROGENASE from Halobacterium volcanii FT (Haloferax volcanii) (474 aa), FASTA scores: opt: 675, E(): FT 6.5e-33, (29.3% identity in 471 aa overlap); FT P50970|DLDH_ZYMMO|LPD DIHYDROLIPOAMIDE DEHYDROGENASE from FT Zymomonas mobilis, FASTA scores: opt: 658, E(): 6.6e-32, FT (30.4% identity in 464 aa overlap); etc. BELONGS TO THE FT PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. FT COFACTOR: FAD (BY SIMILARITY). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT truncation due to a single base transversion (c-a) results FT in a shorter product compared to its homolog in FT Mycobacterium tuberculosis stain H37Rv (471 aa versus 493 FT aa)." FT /db_xref="GOA:Q7TWS4" FT /db_xref="InterPro:IPR006258" FT /db_xref="UniProtKB/TrEMBL:Q7TWS4" FT /protein_id="CAD95423.1" FT /translation="MVTRIVILGGGPAGYEAALVAATSHPETAQVTVIDCDGIGGAAVL FT DDCVPSKTFIASTGLRTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQ FT LLSMGVQVIAGRGELIDSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQ FT PDGERILTWRQLYDLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYED FT ADAALVLEESFAERGVRLFKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIGSVPNT FT SGLGLERVGIQLGRGNYLTVDRVSRTSATGIYAAGDCTGLLPLASVAAMQGRIAMYHAL FT GEGVSPIRLRTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRH FT GFVKIFCRRSTGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSIT FT EAARRLMAHDDLD" FT CDS 202666..203145 FT /transl_table=11 FT /gene="Mb3332" FT /locus_tag="Mb3332" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb3332, -, len: 159 aa. Equivalent to Rv3304, len: FT 159 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 159 aa overlap). Hypothetical conserved FT protein, very similar to Q9CCL6|ML0711 HYPOTHETICAL PROTEIN FT from Mycobacterium leprae (159 aa), FASTA scores: opt: FT 1041, E(): 6.1e-62, (91.8% identity in 159 aa overlap); and FT Q49927|L308_F3_97 from M. leprae (174 aa), FASTA scores: FT opt: 974, E(): 1.8e-57, (91.2% identity in 149 aa overlap) FT . Also highly similar to Q9AD81|SCK13.10c CONSERVED FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (145 aa), FT FASTA scores: opt: 615, E(): 7.8e-34, (60.55% identity in FT 147 aa overlap); and shows some similarity to other various FT hypotheticals proteins. ORF continues upstream with FT possible start at 2198 (equivalent to AAK47746 from FT Mycobacterium tuberculosis strain CDC1551 (212 aa) but FT shorter 53 aa)." FT /db_xref="InterPro:IPR009288" FT /db_xref="UniProtKB/TrEMB |