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EBI DbfetchID BX248341; SV 1; linear; genomic DNA; STD; PRO; 306050 BP. XX AC BX248341; XX DT 10-JUN-2003 (Rel. 76, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 8/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-306050 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF00010; RNaseP_bact_a. XX FH Key Location/Qualifiers FH FT source 1..306050 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS 160..1836 FT /transl_table=11 FT /gene="PE_PGRS35" FT /locus_tag="Mb2005" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb2005, PE_PGRS35, len: 558 aa. Equivalent to FT Rv1983, len: 558 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.8% identity in 558 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins. Similar to other PE proteins e.g. FT Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl FT proteases active site." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZ65" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96858.1" FT /translation="MSFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGAD FT EVSAAVAALFARFGQEYQAVSAQASAFHQQFVQTLNSASGSYAAAEATIASQLQTAQHD FT LLGAVNAPTETLLGRPLIGDGAPGTATSPNGGAGGLLYGNGGNGYSATASGVGGGAGGS FT AGLIGNGGAGGAGGPNAPGGAGGNGGWLLGNGGIGGPGGASSIPGMSGGAGGTGGATGL FT LGWGANGGAGGLGDGVGVDRGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIHVTEPT FT VHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMGLPTGLSISGYSGGLYYIFAT FT YTTTVDFGNGIVTAPTAVNVVLLSIPTSPFAISTYFSALLADPTTTPFEAYFGAVGVDG FT VLGVGPNAVGPGPSIPTMALPGDLNQGVLIDAPAGELVFGPNPLPAPNVEVVGSPITTL FT YVKIDGGTPIPVPSIIDSGGVTGTIPSYVIGSGTLPANTNIEVYTSPGGDRLYAFNTND FT YRPTVISSGLMNTGFLPFRFQPVYIDYSPSGIGTTVFDHPA" FT CDS complement(1824..2477) FT /transl_table=11 FT /gene="cfp21" FT /locus_tag="Mb2006c" FT /product="PROBABLE CUTINASE PRECURSOR CFP21" FT /note="Mb2006c, cfp21, len: 217 aa. Equivalent to Rv1984c, FT len: 217 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 217 aa overlap). cfp21, probable FT cutinase precursor with N-terminal signal sequence (EC FT 3.1.1.-), similar to P41744|CUTI_ALTBR cutinase precursor FT from Alternaria brassicicola (209 aa), FASTA scores: opt: FT 283, E(): 2.2e-11, (32.6% identity in 193 aa overlap). Also FT similar to Mycobacterium tuberculosis proteins e.g. Rv3452, FT Rv3451, Rv2301, Rv1758, Rv3724. BELONGS TO THE CUTINASE FT FAMILY." FT /db_xref="GOA:P63880" FT /db_xref="HSSP:1G66" FT /db_xref="InterPro:IPR011150" FT /db_xref="UniProtKB/Swiss-Prot:P63880" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96859.1" FT /translation="MTPRSLVRIVGVVVATTLALVSAPAGGRAAHADPCSDIAVVFARG FT THQASGLGDVGEAFVDSLTSQVGGRSIGVYAVNYPASDDYRASASNGSDDASAHIQRTV FT ASCPNTRIVLGGYSQGATVIDLSTSAMPPAVADHVAAVALFGEPSSGFSSMLWGGGSLP FT TIGPLYSSKTINLCAPDDPICTGGGNIMAHVSYVQSGMTSQAATFAANRLDHAG" FT CDS complement(2907..3818) FT /transl_table=11 FT /gene="Mb2007c" FT /locus_tag="Mb2007c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LYSR-FAMILY)" FT /note="Mb2007c, -, len: 303 aa. Equivalent to Rv1985c, len: FT 303 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 303 aa overlap). Probable FT transcriptional regulatory protein, LysR family member. FT Similar to many regulatory proteins, especially FT ICIA_ECOLI|P24194 chromosome initiation inhibitor from FT Escherichia coli (297 aa), FASTA scores: opt: 520, E(): FT 1.1e-28, (35.8% identity in 285 aa overlap); and FT P94632|LYSG_CORGL LYSINE EXPORT REGULATOR PROTEIN (290 aa), FT FASTA scores: opt: 705, E(): 0, (42.7% identity in 288 aa FT overlap); etc. Contains PS00044 Bacterial regulatory FT proteins, lysR family signature. Also contains FT helix-turn-helix motif at aa 22-43,(+5.52 SD). BELONGS TO FT THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:P67666" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67666" FT /protein_id="CAD96860.1" FT /translation="MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLE FT QQVGQVLVVREKPCRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRITIAVNAD FT SMATWFSAVFDGLGDVLLDVRIEDQDHSARLLREGVAMGAVTTERNPVPGCRVHPLGEM FT RYLPVASRPFVQRHLSDGFTAAAAAKAPSLAWNRDDGLQDMLVRKAFRRAITRPTHFVP FT TTEGFTAAARAGLGWGMFPEKLAASPLADGSFVRVCDIHLDVPLYWQCWKLDSPIIARI FT TDTVRAAASGLYRGQQRRRRPG" FT CDS 3927..4526 FT /transl_table=11 FT /gene="Mb2008" FT /locus_tag="Mb2008" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb2008, -, len: 199 aa. Equivalent to Rv1986, len: FT 199 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 199 aa overlap). Probable conserved FT integral membrane protein, LysE family possibly involved in FT transport of Lysine, similar to P11667|YGGA_ECOLI FT hypothetical 23.2 kd protein in sbm-fba intergenic region FT (211 aa), FASTA scores: opt: 379, E(): 1.5e-19, (37.3% FT identity in 185 aa overlap); and Q11154|Rv0488 HYPOTHETICAL FT 20.9 KD PROTEIN from Mycobacterium tuberculosis (201 aa), FT FASTA scores: opt: 784, E(): 0, (63.4% identity in 186 aa FT overlap). BELONGS TO THE LYSE/YGGA FAMILY." FT /db_xref="GOA:P64904" FT /db_xref="InterPro:IPR001123" FT /db_xref="UniProtKB/Swiss-Prot:P64904" FT /protein_id="CAD96861.1" FT /translation="MNSPLVVGFLACFTLIAAIGAQNAFVLRQGIQREHVLPVVALCTV FT SDIVLIAAGIAGFGALIGAHPRALNVVKFGGAAFLIGYGLLAARRAWRPVALIPSGATP FT VRLAEVLVTCAAFTFLNPHVYLDTVVLLGALANEHSDQRWLFGLGAVTASAVWFATLGF FT GAGRLRGLFTNPGSWRILDGLIAVMMVALGISLTVT" FT CDS 4942..5370 FT /transl_table=11 FT /gene="Mb2009" FT /locus_tag="Mb2009" FT /product="POSSIBLE CHITINASE" FT /EC_number="3.2.1.14" FT /note="Mb2009, -, len: 142 aa. Equivalent to Rv1987, len: FT 142 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 142 aa overlap). Possible chitinase (EC FT 3.2.1.14), similar to several e.g. P36909|CHIT_STRLI FT chitinase c precursor (619 aa) FASTA scores, opt: 324, E(): FT 1.2e-14, (39.5% identity in 129 aa overlap)." FT /db_xref="GOA:P64906" FT /db_xref="HSSP:1EXG" FT /db_xref="InterPro:IPR012291" FT /db_xref="UniProtKB/Swiss-Prot:P64906" FT /protein_id="CAD96862.1" FT /translation="MAGLNIYVRRWRTALHATVSALIVAILGLAITPVASAATARATLS FT VTSTWQTGFIARFTITNSSTAPLTDWKLEFDLPAGESVLHTWNSTVARSGTHYVLSPAN FT WNRIIAPGGSATGGLRGGLTGSYSPPSSCLLNGQYPCT" FT CDS 5596..6135 FT /transl_table=11 FT /gene="Mb2010" FT /locus_tag="Mb2010" FT /product="PROBABLE METHYLTRANSFERASE" FT /EC_number="2.1.1.-" FT /note="Mb2010, -, len: 179 aa. Equivalent to Rv1988, len: FT 179 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 179 aa overlap). Probable FT methyltransferase (EC 2.1.1.-), similar to FT ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370 FT aa), FASTA scores: opt: 259, E(): 2e-11, (35.1% identity in FT 171 aa overlap); contains PS00092 N-6 Adenine-specific DNA FT methylases signature. Also similar to Mycobacterium FT tuberculosis Rv1010 ksgA 16S rRNA dimethyltransferase." FT /db_xref="GOA:Q7TZ64" FT /db_xref="InterPro:IPR001737" FT /db_xref="UniProtKB/TrEMBL:Q7TZ64" FT /protein_id="CAD96863.1" FT /translation="MSALGRSRRAWGWHRLHDEWAARVVSAAAVRPGELVFDIGAGEGA FT LTAHLVRAGARVVAVELHPRRVGVLRERFPGITVVHADAASIRLPGRPFRVVANPPYGI FT SSRLLRTLLAPNSGLVAADLVLQRALVCKFASRNARRFTLTVGLMLPRRAFLPPPHVDS FT AVLVVRRRKCGDWQGR" FT CDS complement(6655..7215) FT /transl_table=11 FT /gene="Mb2011c" FT /locus_tag="Mb2011c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2011c, -, len: 186 aa. Equivalent to Rv1989c, len: FT 186 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 186 aa overlap). Hypothetical unknown FT protein." FT /db_xref="GOA:P64908" FT /db_xref="InterPro:IPR014914" FT /db_xref="UniProtKB/Swiss-Prot:P64908" FT /protein_id="CAD96864.1" FT /translation="MSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFG FT GRWNPPLLFPAIYLADSAQACMVEVERAAQAASTTAEKMLEAAYRLHTIDVTDLAVLDL FT TTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQRTR FT PGQLQLRQSVDLTPALYQELRAT" FT CDS complement(7212..7553) FT /transl_table=11 FT /gene="Mb2012c" FT /locus_tag="Mb2012c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb2012c, -, len: 113 aa. Equivalent to Rv1990c, len: FT 113 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 113 aa overlap). Probable FT transcriptional regulatory protein, similar to FT Mycobacterium tuberculosis Rv3188|AL021646|MTV014.32 (115 FT aa), FASTA scores: opt: 184, E(): 8.2e-07, (28.4% identity FT in 109 aa overlap). Contains probable helix-turn-helix FT motif at aa 20-44 (+4.22 SD)." FT /db_xref="UniProtKB/Swiss-Prot:P64910" FT /protein_id="CAD96865.1" FT /translation="MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVP FT QRLNKQRLIELAYVADALAEVLPRDQANVWMFSPNRLLEHRKPADLVRDGEYQRVLALI FT DAMAEGVFV" FT CDS complement(7797..8132) FT /transl_table=11 FT /gene="Mb2013c" FT /locus_tag="Mb2013c" FT /product="POSSIBLE DEHYDROGENASE (FRAGMENT)" FT /EC_number="1.-.-.-" FT /note="Mb2013c, -, len: 111 aa. Equivalent to Rv1990A, len: FT 111 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 111 aa overlap). Possible dehydrogenase FT (fragment) (EC 1.-.-.-), similar to N-terminal part of FT several dehydrogenases and hypothetical proteins, e.g. FT Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis FT (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% FT identity in 78 aa overlap), but lacks C-terminal part. FT Maybe a pseudogene. Also similar to U17129|RSU17129_7 FT putative short-chain alcohol dehydrogenase from Rhodococcus FT erythropolis (275 aa), FASTA scores: opt: 142, E(): 0.018, FT (54.15% identity in 48 aa overlap)." FT /db_xref="GOA:Q7TVB7" FT /db_xref="InterPro:IPR002198" FT /db_xref="UniProtKB/TrEMBL:Q7TVB7" FT /protein_id="CAD96866.1" FT /translation="MGRLEGKVAFITGVARGQGRSHAVRLADGQARALGKVDVEACGAL FT VGEVEVWGRDVRDDRRVFVESPADEFGACRRVARQGIRVVGLPVSQRELVEPEAGCAAR FT RSAAGSQ" FT CDS complement(8221..8565) FT /transl_table=11 FT /gene="Mb2014c" FT /locus_tag="Mb2014c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2014c, -, len: 114 aa. Equivalent to Rv1991c, len: FT 114 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 114 aa overlap). Conserved hypothetical FT protein, showing some similarity to P13976|PEMK_ECOLI pemk FT protein (133 aa), FASTA scores: opt: 113, E(): 0.043, FT (29.2% identity in 113 aa overlap); and P96622|YDCE PROTEIN FT from Bacillus subtilis (116 aa), FASTA scores: opt: 227, FT E(): 6.9e-09, (37.4% identity in 115 aa overlap). Also FT similar to Mycobacterium tuberculosis Rv2801c, and FT Rv0659c." FT /db_xref="GOA:P64912" FT /db_xref="HSSP:1NE8" FT /db_xref="InterPro:IPR011067" FT /db_xref="UniProtKB/Swiss-Prot:P64912" FT /protein_id="CAD96867.1" FT /translation="MVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIA FT AVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTAIVTLNKTDLTDRVGEVPASLMHEV FT DRGLRRVLDL" FT CDS complement(8907..11222) FT /transl_table=11 FT /gene="ctpG" FT /locus_tag="Mb2015c" FT /product="PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE G FT CTPG" FT /EC_number="3.6.3.-" FT /note="Mb2015c, ctpG, len: 771 aa. Equivalent to Rv1992c, FT len: 771 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 771 aa overlap). Probable ctpG, metal FT cation-transporting P-type ATPase G (transmembrane protein) FT (EC 3.6.3.-), similar to others, especially FT cadmium-transporting ATPases (EC 3.6.3.3), e.g. FT NP_244904.1|NC_002570 cadmium-transporting ATPase from FT Bacillus halodurans (707 aa); P30336|CADA_BACFI PROBABLE FT CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa); FT BAB47609.1|AB037671 cadmium resistance protein B from FT Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO FT PROBABLE CADMIUM-TRANSPORTING ATPase from Listeria FT monocytogenes (707 aa); etc. Also similar to others from FT Mycobacterium tuberculosis e.g. Rv0969|MTCY10D7.05c|ctpV FT PUTATIVE CATION TRANSPORTER P-TYPE ATPASE V (770 aa); FT Rv1469; Rv0092; etc. Contains PS00435 Peroxidases proximal FT heme-ligand signature and PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB." FT /db_xref="GOA:P63690" FT /db_xref="InterPro:IPR008250" FT /db_xref="UniProtKB/Swiss-Prot:P63690" FT /protein_id="CAD96868.1" FT /translation="MTTVVDAEVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGKV FT AGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYASRSASNRKAGV FT VQKIIDWSTRTLSGVRRDVAAQPSGETSDACCDGEDNEDREPEQLWQVAKLRRAAFSGV FT LLTASLVAAWAYPLWPVVLGLKALALAVGASTFVPSSLKRLAEGRVGVGTLMTIAALGA FT VALGELGEAATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQATVLREGTETIVAST FT ELHVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEVGPGDEVFAGSINGLGV FT LQVGVTATAANNSLARIVHIVEAEQVRKGASQRLADCIARPLVPSIMIAAALIAGTGSV FT LGNPLVWIERALVVLVAAAPCALAIAVPVTVVASIGAASRLGVLIKGGAALETLGTIRA FT VALDKTGTLTANRPVVIDVATTNGATREEVLAVAAALEARSEHPLAVAVLAATQATTAA FT SDVQAVPGAGLIGRLDGRVVRLGRPGWLDAAELADHVACMQQAGATAVLVERDQQLLGA FT IAVRDELRPEAAEVVAGLRTGGYQVTMLTGDNHATAAALAAQAGIEQVHAELRPEDKAH FT LVAQLRARQPTAMVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMGQDLRHLPQ FT ALDHARRSRQIMVQNVGLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIANGVRAG FT RIKPLAGPPKTPDRTIPG" FT CDS complement(11219..11491) FT /transl_table=11 FT /gene="Mb2016c" FT /locus_tag="Mb2016c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2016c, -, len: 90 aa. Equivalent to Rv1993c, len: FT 90 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 90 aa overlap). Conserved hypothetical FT protein, very similar to Rv3269|Z92771|MTCY71.09 FT hypothetical protein from Mycobacterium tuberculosis (93 FT aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity FT in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% FT identity in 94 aa overlap)." FT /db_xref="InterPro:IPR009963" FT /db_xref="UniProtKB/Swiss-Prot:P64914" FT /protein_id="CAD96869.1" FT /translation="MVTHELLVKAAGAVLTGLVGVSAYETLRKALGTAPIRRASVTVME FT WGLRGTRRAEAAAESARLTVADVVAEARGRIGEEAPLPAGARVDE" FT CDS complement(11544..11900) FT /transl_table=11 FT /gene="Mb2017c" FT /locus_tag="Mb2017c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb2017c, -, len: 118 aa. Equivalent to Rv1994c, len: FT 118 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.000% identity in 118 aa overlap). Probable FT transcription regulator, similar to MERR_STRLI|P30346 FT probable mercury resistance operon repressor (125 aa), FT FASTA scores: opt: 199, E(): 3e-08, (36.3% identity in 102 FT aa overlap). Contains probable helix-turn-helix motif at aa FT 36-57 (+3.78 SD)." FT /db_xref="GOA:P67732" FT /db_xref="HSSP:1SMT" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67732" FT /protein_id="CAD96870.1" FT /translation="MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHLG FT LTRSNVSNHLSCLRGCGLVVATYEGRQVRYALADSHLARALGELVQVVLAVDTDQPCVA FT ERAASGEAVEMTGS" FT CDS 12057..12824 FT /transl_table=11 FT /gene="Mb2018" FT /locus_tag="Mb2018" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2018, -, len: 255 aa. Equivalent to Rv1995, len: FT 255 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 255 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR012312" FT /db_xref="UniProtKB/Swiss-Prot:P64916" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96871.1" FT /translation="MVASGAATKGVTVMKQTPPAAVGRRHLLEISASAAGVIALSACSG FT SPPEPGKGRPDTTPEQEVPVTAPEDLMREHGVLKRILLIYREGIRRLQADDQSPAPALN FT ESAQIIRRFIEDYHGQLEEQYVFPKLEQAGKLTDITSVLRTQHQRGRVLTDRVLAATTA FT AAAFDQPARDTLAQDMAAYIRMFEPHEAREDTVVFPALRDVMSAVEFRDMAETFEDEEH FT RRFGEAGFQSVVDKVADIEKSLGIYDLSQFTPS" FT CDS 12920..13873 FT /transl_table=11 FT /gene="Mb2019" FT /locus_tag="Mb2019" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2019, -, len: 317 aa. Identical to Rv1996, len: FT 317 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.000% identity in 317 aa overlap). Conserved FT hypothetical protein. Similar to several Mycobacterium FT tuberculosis hypothetical proteins e.g. FT Rv2005c|Q10851|YK05_MYCTU (295 aa), FASTA scores: opt: 775, FT E(): 0, (50.3% identity in 316 aa overlap); Rv2026c (294 FT aa) (47.9% identity in 311 aa overlap); and Rv2623, etc. FT Also similar to SCJ1.30c|AL109962 hypothetical protein from FT Streptomyces coelicolor (328 aa)." FT /db_xref="GOA:P0A5F8" FT /db_xref="InterPro:IPR006016" FT /db_xref="UniProtKB/Swiss-Prot:P0A5F8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96872.1" FT /translation="MSAQQTNLGIVVGVDGSPCSHTAVEWAARDAQMRNVALRVVQVVP FT PVITAPEGWAFEYSRFQEAQKREIVEHSYLVAQAHQIVEQAHKVALEASSSGRAAQITG FT EVLHGQIVPTLANISRQVAMVVLGYRGQGAVAGALLGSVSSSLVRHAHGPVAVIPEEPR FT PARPPHAPVVVGIDGSPTSGLAAEIAFDEASRRGVDLVALHAWSDMGPLDFPRLNWAPI FT EWRNLEDEQEKMLARRLSGWQDRYPDVVVHKVVVCDRPAPRLLELAQTAQLVVVGSHGR FT GGFPGMHLGSVSRAVVNSGQAPVIVARIPQDPAVPA" FT CDS 14075..16792 FT /transl_table=11 FT /gene="ctpF" FT /locus_tag="Mb2020" FT /product="PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE A FT CTPF" FT /EC_number="3.6.3.-" FT /note="Mb2020, ctpF, len: 905 aa. Equivalent to Rv1997, FT len: 905 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 905 aa overlap). Probable ctpF, metal FT cation-transporting P-type ATPase F (transmembrane protein) FT (EC 3.6.3.-), highly similar to others e.g. FT NP_250120.1|NC_002516 probable cation-transporting P-type FT ATPase from Pseudomonas aeruginosa (902 aa); FT NP_441217.1|NC_000911 cation-transporting ATPase (E1-E2 FT ATPase) from Synechocystis sp. strain PCC 6803 (905 aa); FT NP_404093.1|NC_003143 putative cation-transporting P-type FT ATPase from Yersinia pestis (908 aa); P37367|ATA1_SYNY3 FT cation-transporting ATPase pma1 from Synechocystis sp. (915 FT aa), FASTA scores: opt: 2392, E(): 0, (46.5% identity in FT 852 aa overlap); etc. Contains PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Was FT frame-shifted in original cosmid sequence." FT /db_xref="GOA:P63688" FT /db_xref="HSSP:1EUL" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:P63688" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96873.1" FT /translation="MSASVSATTAHHGLPAHEVVLLLESDPYHGLSDGEAAQRLERFGP FT NTLAVVTRASLLARILRQFHHPLIYVLLVAGTITAGLKEFVDAAVIFGVVVINAIVGFI FT QESKAEAALQGLRSMVHTHAKVVREGHEHTMPSEELVPGDLVLLAAGDKVPADLRLVRQ FT TGLSVNESALTGESTPVHKDEVALPEGTPVADRRNIAYSGTLVTAGHGAGIVVATGAET FT ELGEIHRLVGAAEVVATPLTAKLAWFSKFLTIAILGLAALTFGVGLLRRQDAVETFTAA FT IALAVGAIPEGLPTAVTITLAIGMARMAKRRAVIRRLPAVETLGSTTVICADKTGTLTE FT NQMTVQSIWTPHGEIRATGTGYAPDVLLCDTDDAPVPVNANAALRWSLLAGACSNDAAL FT VRDGTRWQIVGDPTEGAMLVVAAKAGFNPERLATTLPQVAAIPFSSERQYMATLHRDGT FT DHVVLAKGAVERMLDLCGTEMGADGALRPLDRATVLRATEMLTSRGLRVLATGMGAGAG FT TPDDFDENVIPGSLALTGLQAMSDPPRAAAASAVAACHSAGIAVKMITGDHAGTATAIA FT TEVGLLDNTEPAAGSVLTGAELAALSADQYPEAVDTASVFARVSPEQKLRLVQALQARG FT HVVAMTGDGVNDAPALRQANIGVAMGRGGTEVAKDAADMVLTDDDFATIEAAVEEGRGV FT FDNLTKFITWTLPTNLGEGLVILAAIAVGVALPILPTQILWINMTTAIALGLMLAFEPK FT EAGIMTRPPRDPDQPLLTGWLVRRTLLVSTLLVASAWWLFAWELDNGAGLHEARTAALN FT LFVVVEAFYLFSCRSLTRSAWRLGMFANRWIILGVSAQAIAQFAITYLPAMNMVFDTAP FT IDIGVWVRIFAVATAITIVVATDTLLPRIRAQPP" FT CDS complement(16861..17637) FT /transl_table=11 FT /gene="Mb2021c" FT /locus_tag="Mb2021c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2021c, -, len: 258 aa. Equivalent to Rv1998c, len: FT 258 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 258 aa overlap). Conserved hypothetical FT protein, showing some similarity with other hypothetical FT proteins e.g. U82823|SEU82823.03 Saccharopolyspora FT erythraea (266 aa), FASTA results: opt: 654, E(): 0, (43.8% FT identity in 249 aa overlap); and AL034446|SC1A9.07 FT Streptomyces coelicolor (251 aa), FASTA scores: opt: 592, FT E(): 1.5e-31, (43.4% identity in 251 aa overlap)." FT /db_xref="GOA:Q7TZ63" FT /db_xref="InterPro:IPR015813" FT /db_xref="UniProtKB/TrEMBL:Q7TZ63" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96874.1" FT /translation="MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSSS FT GGHPDGHRATRGANIALAAALAPLQCYVSVDIEDGYSDEPDAIADYVAQLSTAGINIED FT SSAEKLIDPALAAAKIVAIKQRNPEVFVNARVDTYWLRQHADTTSTIQRALRYVDAGAD FT GVFVPLANDPDELAELTRNIPCPVNTLPVPGLTIADLGELGVARVSTGSVPYSAGLYAA FT AHAARAVRDGEQLPRSVPYAELQARLVDYENRTSTT" FT CDS complement(17732..19054) FT /transl_table=11 FT /gene="Mb2022c" FT /locus_tag="Mb2022c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb2022c, -, len: 440 aa. Equivalent to Rv1999c, len: FT 440 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 440 aa overlap). Probable conserved FT integral membrane protein, possibly transporter of cationic FT amino acid, similar to many transporters, especially amino FT acid transporters, e.g. CAC08265.1|AL392146 putative amino FT acid transporter from Streptomyces coelicolor (414 aa); FT P39277|YJEH_ECOLI hypothetical 44.8 kd protein from FT Escherichia coli (418 aa), FASTA scores, opt: 343, E(): FT 6.6e-15, (27.2% identity in 408 aa overlap); etc. Also FT similar to Rv1979c from Mycobacterium tuberculosis, FASTA FT score: (28.2% identity in 277 aa overlap); Rv2127, Rv0346c, FT Rv0522, etc. SEEMS TO BELONG TO THE APC FAMILY." FT /db_xref="GOA:P63350" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/Swiss-Prot:P63350" FT /protein_id="CAD96875.1" FT /translation="MRRPLDPRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAY FT AAGSGLLLGLAVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVV FT GKTASCAAMALTVGFYVWPAQAHAVAVAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVL FT TAVVVAAYGSGAADPARLDIGVDAHVWGMLQAAGLLFFAFAGYARIATLGEEVRDPART FT IPRAIPLALGITLAVYALVAVAVIAVLGPQRLARAAAPLSEAMRVAGVNWLIPVVQIGA FT AVAALGSLLALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAAT FT ADIRGAIGFSSFGVLVYYAIANASALTLGLDEGRPRRLIPLVGLIGCVVLAFALPLSSV FT AAGAAVLGVGVAAYGVRRIITRRARQTDSGDTQRSGHPSAT" FT CDS 19125..20738 FT /transl_table=11 FT /gene="Mb2023" FT /locus_tag="Mb2023" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2023, -, len: 537 aa. Equivalent to Rv2000, len: FT 537 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 537 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/Swiss-Prot:P64918" FT /protein_id="CAD96876.1" FT /translation="MRPGFVGLGFGQWPVYVVRWPKLHLTPRQRKRVLHRRRLLTDRPI FT SLSQIPIRTGGPMNDPWPRPTQGPAKTIETDYLVIGAGAMGMAFTDTLITESGARVVMI FT DRACQPGGHWTTAYPFVRLHQPSAYYGVNSRALGNNTIDLVGWNQGLNELAPVGEICAY FT FDAVLQQQLLPTGRVDYFPMSEYLGDGRFRTLAGTEYVVTVNRRIVDATYLRAVVPSMR FT PAPYSVAPGVDCVAPNELPKLGTRDRYVVVGAGKTGMDVCLWLLRNDVCPDKLTWIMPR FT DSWLIDRATLQPGPTFVRQFRESYGATLEAIGAATSTDDLFDRLETAGTLLRIDPSVRP FT SMYRCATVSHLELEQLRRIRDIVRMGHVQRIEPTTIVLDGGSVPATPTALYIDCTADGA FT PQRPAKPVFDADHLTLQAVRGCQQVFSAAFIAHVEFAYEDDAVKNELCTPIPHPDCDLD FT WMRLMHSDLGNFQRWLNDPDLTDWLSSARLNLLADLLPPLSHKPRVRERVVSMFQKRLG FT TAGDQLAKLLDAATATTEQR" FT CDS 20748..21500 FT /transl_table=11 FT /gene="Mb2024" FT /locus_tag="Mb2024" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2024, -, len: 250 aa. Equivalent to Rv2001, len: FT 250 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 250 aa overlap). Conserved hypothetical FT protein. Similar to Mycobacterium tuberculosis Rv0466, FT AL021933|MTV038_10 (264 aa), FASTA scores: opt: 592, E():0, FT (38.0% identity in 263 aa overlap)." FT /db_xref="InterPro:IPR002864" FT /db_xref="UniProtKB/TrEMBL:Q7TZ62" FT /protein_id="CAD96877.1" FT /translation="MHHNRDVDLALVERPSSGYVYTTGWRLATTDIDEHQQLRLDGVAR FT YIQEVGAEHLADAQLAEVHPHWIVLRTVIDVINPIELPSDITFHRWCAALSTRWCSMRV FT QLQGSAGGHIETEGFWICVNKDTLTPSRLTDDCIARFGSTTENHRLKWRPWLTGPNIDG FT TETPFPLRRTDIDPFEHVNNTIYWHGVHEILCQIPTLTAPYRAVLEYRSPIKSGEPLTI FT RYEQHDDVVRMHFVVGDDVRAAALLRRL" FT CDS 21576..22358 FT /transl_table=11 FT /gene="fabG3" FT /locus_tag="Mb2025" FT /product="POSSIBLE 20-BETA-HYDROXYSTEROID DEHYDROGENASE FT FABG3 (Cortisone reductase) ((R)-20-hydroxysteroid FT dehydrogenase)" FT /EC_number="1.1.1.53" FT /note="Mb2025, fabG3, len: 260 aa. Equivalent to Rv2002, FT len: 260 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 260 aa overlap). Possible fabG3, FT 20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53), similar FT to e.g. 2BHD_STREX|P19992 20-beta-hydroxysteroid FT dehydrogenase (255 aa), FASTA scores: opt: 718, E(): 2e-38, FT (49.8% identity in 243 aa overlap), and many mycobacterial FT proteins. Contains PS00061 Short-chain alcohol FT dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P69166" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P69166" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96878.1" FT /translation="MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGK FT AVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTE FT WQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGL FT TKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASD FT ESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT" FT CDS complement(22479..23336) FT /transl_table=11 FT /gene="Mb2026c" FT /locus_tag="Mb2026c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2026c, -, len: 285 aa. Equivalent to Rv2003c, len: FT 285 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 285 aa overlap). Conserved hypothetical FT protein. Some similarity with Methanococcus jannaschii FT 67555|U67555_3 (205 aa), FASTA scores: opt: 357, E(): FT 3.2e-17, (33.8% identity in 204 aa overlap)." FT /db_xref="GOA:P64920" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P64920" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96879.1" FT /translation="MVKRSRATRLSPSIWSGWESPQCRSIRARLLLPRGRSRPPNADCC FT WNQLAVTPDTRMPASSAAGRDAAAYDAWYDSPTGRPILATEVAALRPLIEVFAQPRLEI FT GVGTGRFADLLGVRFGLDPSRDALMFARRRGVLVANAVGEAVPFVSRHFGAVLMAFTLC FT FVTDPAAIFRETRRLLADGGGLVIGFLPRGTPWADLYALRAARGQPGYRDARFYTAAEL FT EQLLADSGFRVIARRCTLHQPPGLARYDIEAAHDGIQAGAGFVAISAVDQAHEPKDDHP FT LESE" FT CDS complement(23394..24890) FT /transl_table=11 FT /gene="Mb2027c" FT /locus_tag="Mb2027c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2027c, -, len: 498 aa. Equivalent to Rv2004c, len: FT 498 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 498 aa overlap). Conserved hypothetical FT protein similar to several e.g. >pir||T36945 hypothetical FT protein SCJ1.12 (508 aa) - Streptomyces coelicolor FT >gi|5748625|emb|CAB53130.1| (AL109962). Smith-Waterman FT score: 7e-94, Identities = 199/468 (42%). Contains PS00017 FT ATP/GTP-binding site motif A." FT /db_xref="GOA:P0A5G0" FT /db_xref="UniProtKB/Swiss-Prot:P0A5G0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96880.1" FT /translation="MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPV FT VTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQ FT RLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHH FT ADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALL FT DCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIA FT YRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLAR FT GVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLG FT SGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATA FT EIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI" FT CDS complement(24912..25799) FT /transl_table=11 FT /gene="Mb2028c" FT /locus_tag="Mb2028c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2028c, -, len: 295 aa. Equivalent to Rv2005c, len: FT 295 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 295 aa overlap). Conserved hypothetical FT protein, similar to MTCY39.23c, (50.3% identity in 316 aa FT overlap), C-terminus shows some similarity with YXIE_BACSU FT P42297 hypothetical 15.9 kd protein in bglh- (148 aa), FT FASTA scores, opt: 124, E(): 0.038, (28.5% identity in 144 FT aa overlap), also similar to Rv2623 (294 aa), (52.7% FT identity in 296 aa overlap) and other Mycobacterium FT tuberculosis hypothetical proteins e.g. Rv1996, Rv2624c, FT Rv2028c, Rv3134c, Rv1636. Some, possibly all, of these FT belong to universal stress protein family." FT /db_xref="GOA:P64922" FT /db_xref="InterPro:IPR006016" FT /db_xref="UniProtKB/Swiss-Prot:P64922" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96881.1" FT /translation="MSKPRKQHGVVVGVDGSLESDAAACWGATDAAMRNIPLTVVHVVN FT ADVATWPPMPYPETWGVWQEDEGRQIVANAVKLAKEAVGADRKLSVKSELVFSTPVPTM FT VEISNEAEMVVLGSSGRGALARGLLGSVSSSLVRRAGCPVAVIHSDDAVIPDPQHAPVL FT VGIDGSPVSELATAVAFDEASRRGVELIAVHAWSDVEVVELPGLDFSAVQQEAELSLAE FT RLAGWQERYPDVPVSRVVVCDRPARKLVQKSASAQLVVVGSHGRGGLTGMLLGSVSNAV FT LHAARVPVIVARQS" FT CDS 25918..29901 FT /transl_table=11 FT /gene="otsB1" FT /locus_tag="Mb2029" FT /standard_name="otsB" FT /product="PROBABLE TREHALOSE-6-PHOSPHATE PHOSPHATASE OTSB1 FT (TREHALOSE-PHOSPHATASE) (TPP)" FT /EC_number="3.2.1.28" FT /note="Mb2029, otsB1, len: 1327 aa. Equivalent to Rv2006, FT len: 1327 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 1327 aa overlap). Probable otsB1, FT trehalose-6-phosphate phosphatase (EC 3.1.3.12) (see FT citations below); strong similarity in central domain to FT OTSB_ECOLI P31678 trehalose-phosphatase (266 aa) and M. FT leprae TREHALOSE-PHOSPHATASE Q49734 (429 aa). Belongs to FT Glycosyl hydrolases family 65 FT (http://www.expasy.ch/cgi-bin/lists?glycosid.txt). FASTA FT scores, sp|Q49734|Q49734 PUTATIVE TREHALOSE-PHOSPHATASE FT (429 aa) opt: 1283 E(): 0; 51.7% identity in 420 aa overlap FT opt: 278, E(): 3.6e-11, (29.4% identity in 255 aa overlap). FT Note that previously known as otsB." FT /db_xref="GOA:Q7TZ61" FT /db_xref="InterPro:IPR003337" FT /db_xref="UniProtKB/TrEMBL:Q7TZ61" FT /protein_id="CAD96882.1" FT /translation="MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTK FT FLDDYLTRRPQRTGEDHCPLTHDDYRRFLAGKPDSVADFLAARGIRLPPGSPTDLTDDT FT VYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSHRNYGHTLDATGLA FT EVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANPGRCVVIDSCQTGLRAGRNGGFA FT LVIAVDAHGDAENLLSSGADAVVADLAAVTVGSGDAAISTIPDALQVYSQLKRLLTGRR FT PAVFLDFDGTLSDIVERPEAATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDG FT LWLAGSHGFELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAV FT HYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDWIGERLGPA FT EVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVRHNEHGDRRSAATFRLECPYTVCQF FT LSQLACDLQEAVQHDDPWTLVFHGYDPGQERLREALCAVGNGYLGSRGCAPESAESEAH FT YPGTYVAGVYNQLTDHIEGCTVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQT FT FDLRRATLTRSLRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLV FT DGGVHNTLVDRYRQLSSQHLTTAEIEVLADSVLLRTQTSQSGIAIAVAARSTLWRDGQR FT VDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDAATLTAAISAQRCLGEAG FT RYAELCQQHVRAWARLWERCAIDLTGNTEELRLVRLHLLHLLQTISPHTAELDAGVPAR FT GLNGEAYRGHVFWDALFVAPVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYP FT WQSGSDGSEVSQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCG FT AELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNVMAVW FT VILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFHDGVISQFEGYSEL FT AELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQADALMLLYLLSSDELIGLLARL FT GYRFAPTQIPGTVDYYLARTSDGSTLSAVVHAWVLARANRSNAMEYFRQVLRSDIADVQ FT GGTTQEGIHLAAMAGSIDLPQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLS FT LRISGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR" FT CDS complement(30000..30344) FT /transl_table=11 FT /gene="fdxA" FT /locus_tag="Mb2030c" FT /product="PROBABLE FERREDOXIN FDXA" FT /note="Mb2030c, fdxA, len: 114 aa. Equivalent to Rv2007c, FT len: 114 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 114 aa overlap). Probable fdxA, FT ferredoxin, similar to e.g. FER_MYCSM P00215 ferredoxin, FT Mycobacterium smegmatis (106 aa), FASTA scores, opt: 448, FT E(): 1 .6e-21, (58.7% identity in 109 aa overlap), also FT similar to Rv0886|MTCY31.14, (34.2% identity in 117 aa FT overlap) and fdxC|Rv1177." FT /db_xref="GOA:P64123" FT /db_xref="HSSP:1H98" FT /db_xref="InterPro:IPR000813" FT /db_xref="UniProtKB/Swiss-Prot:P64123" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96883.1" FT /translation="MTYVIGSECVDVMDKSCVQECPVDCIYEGARMLYINPDECVDCGA FT CKPACRVEAIYWEGDLPDDQHQHLGDNAAFFHQVLPGRVAPLGSPGGAAAVGPIGVDTP FT LVAAIPVECP" FT CDS complement(30533..31858) FT /transl_table=11 FT /gene="Mb2031c" FT /locus_tag="Mb2031c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2031c, -, len: 441 aa. Equivalent to Rv2008c, len: FT 441 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 441 aa overlap). Conserved hypothetical FT protein. Contains PS00017 ATP/GTP-binding site motif A, FT PS00501 Signal peptidases I serine active site. Also FT contains helix-turn-helix motif at aa 258-279. Similar to FT several conserved hypothetical proteins e.g. FT NP_085874.1|14028123|dbj|BAB54715.1 hypothetical protein FT from Mesorhizobium loti (435 aa). Smith-Waterman score: FT 1e-74, Identities = 158/359 (44%)" FT /db_xref="GOA:P64924" FT /db_xref="UniProtKB/Swiss-Prot:P64924" FT /protein_id="CAD96884.1" FT /translation="MDEIESLIGLRPTPLTWPVVIAGDFLGVWDPPPSLPGAANHEISA FT PTARISCMLIERRDAAARLRRALHRAPVVLLTGPRQAGKTTLSRLVGKSAPECTFDAEN FT PVDATRLADPMLALSGLSGLITIDEAQRIPDLFPVLRVLVDRPVMPARFLILGSASPDL FT VGLASESLAGRVELVELSGLTVRDVGSSAADRLWLRGGLPPSFTARSNEDSAAWRDGYI FT TTFLERDLAQLGVRIPAATMRRAWTMLAHYHGQLFSGAELARSLDVAQTTARRYLDALT FT DALVVRQLTPWFANIGKRQRRSPKIYIRDTGLLHRLLGIDDRLALERNPKLGASWEGFV FT LEQLAALLAPNPLYYWRTQQDAELDLYVELSGRPYGFEIKRTSTPSISRSMRSALVDLQ FT LARLAIVYPGEHRFPLSDTVVAVPADQILTTGSVDELLALLK" FT CDS 31946..32188 FT /transl_table=11 FT /gene="Mb2032" FT /locus_tag="Mb2032" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2032, -, len: 80 aa. Equivalent to Rv2009, len: 80 FT aa, from Mycobacterium tuberculosis strain H37Rv, (98.8% FT identity in 80 aa overlap). Conserved hypothetical protein, FT very similar to Rv1560|MTCY48.05c (54.4% identity in 68 aa FT overlap)." FT /db_xref="InterPro:IPR019239" FT /db_xref="UniProtKB/TrEMBL:Q7TZ60" FT /protein_id="CAD96885.1" FT /translation="MYSGVVSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEP FT LGRDEALALQGSGFDFSDDEIESFSDTDRKLADES" FT CDS 32189..32587 FT /transl_table=11 FT /gene="Mb2033" FT /locus_tag="Mb2033" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2033, -, len: 132 aa. Equivalent to Rv2010, len: FT 132 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 132 aa overlap). Conserved hypothetical FT protein, similar to Rv1561|MTCY48.04c, (38.1% identity in FT 126 aa overlap)" FT /db_xref="InterPro:IPR006596" FT /db_xref="UniProtKB/Swiss-Prot:P64926" FT /protein_id="CAD96886.1" FT /translation="MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLI FT GKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAIHRRCRRGGDTVRSLIDCQVAAMAL FT RIGVAVAHRDRDYEAIRTHCGLRTEPLF" FT CDS complement(32770..33201) FT /transl_table=11 FT /gene="Mb2034c" FT /locus_tag="Mb2034c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2034c, -, len: 143 aa. Equivalent to Rv2011c, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 143 aa overlap). Conserved hypothetical FT protein, some similarity to putative regulatory proteins FT e.g. putative marR-family regulatory protein from FT Streptomyces coelicolor A3(2) (157 aa), emb|CAB63189.1| FT (AL133469) 34% identity in 110 aa overlap. Low similarity FT to PETP_RHOCA P31078 petp protein. Rhodobacter capsulatus FT (166 aa), FASTA scores, opt: 101, E(): 0 .36, (31.8% FT identity in 88 aa overlap)" FT /db_xref="UniProtKB/Swiss-Prot:P64928" FT /protein_id="CAD96887.1" FT /translation="MSDEIARLVADVFELAGLLRRSGEVVAAREGHTQARWQLLSVVSD FT RALTVPQAARRLGVTRQGVQRVANDLVVCGLAELRHNPDHRTSPLLVLTENGRRVLQAI FT TERAIVVNNRLADAVDPAALQATRDSLRRMIVALKAERP" FT CDS 33242..33736 FT /transl_table=11 FT /gene="Mb2035" FT /locus_tag="Mb2035" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2035, -, len: 164 aa. Equivalent to Rv2012, len: FT 164 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 164 aa overlap). Conserved hypothetical FT protein, similar to AAK04358.1|AE006263_5 hypothetical FT protein from Lactococcus lactis (137 aa), (48% identity in FT 129 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64930" FT /protein_id="CAD96888.1" FT /translation="MLSKSKRSCRRRETLRIGEKMSAPITNLQAAQRDAIMNRPAVNGF FT PHLAETLRRAGVRTNTWWLPAMQSLYETDYGPVLDQGVPLIDGVAEVPAFDRTALVTAL FT RADQAGQTSFREFAAAAWRAGVLRYVVDLENRTCTYFGLHDQTYMEHYAAVEPSGGAPT FT S" FT repeat_region 34359..35586 FT /mobile_element="insertion sequence:IS1607" FT /locus_tag="IS1607" FT /note="IS1607, len: 1228 nt. Equivalent to IS1607, len: FT 1228 nt, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 1084 nt overlap )." FT CDS 34440..35060 FT /transl_table=11 FT /gene="Mb2036" FT /locus_tag="Mb2036" FT /product="POSSIBLE TRANSPOSASE" FT /note="Mb2036, -, len: 206 aa. Similar to Rv2013, len: 159 FT aa, from Mycobacterium tuberculosis strain H37Rv. Possible FT transposase: shows similarity to N-terminal part of FT transposase and insertion element hypothetical proteins eg FT sp|Q53198|Y4UE_RHISN PUTATIVE TRANSPOSASE Y4UE (359 aa) FT opt: 383, E(): 1.3e-18; 35.1% identity in 225 aa overlap; FT sp|P 14707|YM3_STRCO MINI-CIRCLE HYPOTHETICAL 45.7 KD P FT (414 aa) opt: 302, E(): 4.2e-13; 33.3% identity in 207 aa FT overlap; and YI90_MYCPA P14322 insertion element is900 FT hypothetical protein (399 aa), FASTA scores, opt: 146, E(): FT 0.0021, (26.9% identity in 145 aa overlap). Length changed FT since first submission (no clear start apparent). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT single base transition (c-t) at the 5' start of Mb2036, FT leads to a longer product with a different NH2 part FT compared toits homolog in Mycobacterium tuberculosis strain FT H37Rv (206 aa versus 159 aa)." FT /db_xref="GOA:Q7TZ59" FT /db_xref="InterPro:IPR002525" FT /db_xref="UniProtKB/TrEMBL:Q7TZ59" FT /protein_id="CAD96889.1" FT /translation="MSIVDARGREVRRATIEHNAAGLRELLELLSRAGAREVAIERPDG FT PVVDTLLEAGITVVVISPNQLKNLRGRYGSAGNKDDRFDAFVLADTLRTDRSRLRPLLP FT DTPATATLRRTCRPRKDLVAHRVALANQLRAHLRVVFPGVVGLFADLDSPISLAFLTFL FT PRFDCQDRADWLSVKRLAGWLAAAGYCGRAPRPAHRCPARRHR" FT CDS 35014..35604 FT /transl_table=11 FT /gene="Mb2037" FT /locus_tag="Mb2037" FT /product="POSSIBLE TRANSPOSASE" FT /note="Mb2037, -, len: 196 aa. Equivalent to Rv2014, len: FT 196 aa, from Mycobacterium tuberculosis strain H37Rv, (). FT Possible transposase, similar to insertion elements e.g. FT sp|P14707|YM3_STRCO MINI-CIRCLE HYPOT HETICAL 45.7 KD P FT (414 aa) opt: 249 z-score: 307.0 E(): 1.4e-09; 33.1% FT identity in 169 aa overlap; and YI90_MYCPA P14322 insertion FT element is900 hypothetical protein (399 a a), FASTA scores, FT opt: 242, z-score: 299.9, E(): 3.7e-10, (3 2.5% identity in FT 163 aa overlap); possibly made by frameshifting with FT respect to upstream ORF. Length changed since first FT submission." FT /db_xref="GOA:Q7TZ58" FT /db_xref="InterPro:IPR003346" FT /db_xref="UniProtKB/TrEMBL:Q7TZ58" FT /protein_id="CAD96890.1" FT /translation="MLHDRLTGAPRGATGDEGAANAHITRAMVAALTSVATQIKTLDAQ FT IAEQLSLHADAHIFTSLPRSGTVRAARLLAEIGDCRARFPTPESLACLAGVAPSTRQSG FT KVKHVGFRWAADKQLRDAVCDFAGDSRRANLWAADRYNRAIARGHDHPHAVRILARAWL FT YAIWHCWQDGAAYHPANHRALQALLNQDQDRAA" FT CDS complement(35732..36988) FT /transl_table=11 FT /gene="Mb2038c" FT /locus_tag="Mb2038c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2038c, -, len: 418 aa. Equivalent to Rv2015c, len: FT 418 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 418 aa overlap). Conserved hypothetical FT protein. Nearly identical to Mycobacterium tuberculosis FT Rv1765c|MTCY28.31c, (378 aa), an ORF starting next to ISB9, FT and ending in IS6110. Different N-terminus chosen and FT C-terminus differs as that of Rv1765c has been truncated by FT IS6110. Does NOT show similarities with transposases. BLAST FT hits with non-IS part of MTU78639. FASTA scores: FT Z95890|MTCY28_31 (378 aa) opt: 2417, E(): 0, (97.8% FT identity in 364 aa overlap)." FT /db_xref="GOA:Q7TZ57" FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:Q7TZ57" FT /protein_id="CAD96891.1" FT /translation="MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVAE FT LDRDGLWGVTGARLVAGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSLDQ FT VGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSADEQ FT FSCWRIKLPHVEAAKFDAALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAFLRLV FT EAGWDAEVARRPHGQHTTVVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEAWFERD FT GQVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGATELANLV FT LVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPPPAVAPWPGPTGE FT RADWWWYEPFQPQPPPISN" FT CDS 37342..37917 FT /transl_table=11 FT /gene="Mb2039" FT /locus_tag="Mb2039" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2039, -, len: 191 aa. Equivalent to Rv2016, len: FT 191 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 191 aa overlap). Hypothetical protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZ56" FT /protein_id="CAD96892.1" FT /translation="MTELGDKFLAALVGTIRDTRFDIADMRNWRPGWFPTMHSRCLSNL FT IHDRIWAHLVTLIASNPGTSIKDKGATREIVVGAHLRLRIKRHHAGDEISTYPTRTAIE FT FWQQGSQPAFPGLEEVRIAVGYRWDPDTREIGAPLLSLRDGKDHVIWVVELDEPAAGVK FT ITWTPIEPTLPSIDFGDLGEDSGASGER" FT CDS 37914..38954 FT /transl_table=11 FT /gene="Mb2040" FT /locus_tag="Mb2040" FT /product="hypothetical regulatory protein" FT /note="Mb2040, -, len: 346 aa. Equivalent to Rv2017, len: FT 346 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 346 aa overlap). Hypothetical regulatory FT protein, shows similarity at N-terminal end to several FT transcriptional regulators e.g. Bacillus subtilis FT BSUB0012_44 (108 aa). Contains PS00142 Neutral zinc FT metallopeptidases, zinc-binding region signature in FT C-terminal half, may be fortuitous. FASTA scores: FT Z99115|BSUB0012_44 Bacillus subtilis (108 aa) opt: 154, FT E(): 0.0012; 35.5% identity in 62 aa overlap. Contains FT probable helix-turn-helix motif at aa 18-39 (Score 2243, FT +6.83 SD)" FT /db_xref="GOA:Q7VET2" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:Q7VET2" FT /protein_id="CAD96893.1" FT /translation="MNGLGDVLAVARKARGLTQIELAELVGLTQPAINRYESGDRDPDQ FT HIVAKLAEILGVTDDLLIHGNRFRGALAVDAHMRRHKTTKASAWRQLEARLNLLRVHAS FT FLFEEVAINSEQHVPAFDPEFTAAEDAARLVRAQWRMPMGPVVNLTRWMEAAGCLVFEE FT DFATQRIDGLSQWVDDYPVMLINANAAPDRKRLTLAHELGHLVLHSTNPTENMETEATA FT FAAEFLMPESEIRPELRRLDLGKLLELKREWGVSMQALLERAYRMGLVSAEARTKLYKA FT MNARGWKTKEPGIESIVREKPSLPAHIGMTLRSRGFTDQQAAAIAGYANPADNPFRPEG FT GRLHAI" FT CDS 39196..39915 FT /transl_table=11 FT /gene="Mb2041" FT /locus_tag="Mb2041" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2041, -, len: 239 aa. Equivalent to Rv2018, len: FT 239 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 239 aa overlap). Conserved hypothetical FT protein, similar to Rv2308|MTCY339.01c (238 aa). FASTA FT scores: Z77163|MTCY339_1 Mycobacterium tuberculosis cosmid FT (238 aa) opt: 142, E(): 0.029; (24.8% identity in 250 aa FT overlap). Contains probable helix-turn-helix motif at aa FT 215-236 (Score 1175, +3.19 SD)." FT /db_xref="InterPro:IPR017277" FT /db_xref="UniProtKB/TrEMBL:Q7TZ55" FT /protein_id="CAD96894.1" FT /translation="MAGDQELELRFDVPLYTLAEASRYLVVPRATLATWADGYERRPAN FT APAVQGQPIITALPHPTGSHARLPFVGIAEAYVLNAFRRAGVPMQRIRPSLDWLIKNVG FT PHALASQDLCTGGAEVLWRFAERSGEGSPDDLVVRGLIVPRSGQYVFKEIVEHYLQQIS FT FADDNLASMIRLPQYGDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADD FT YGVTPDQLRDALDAIAA" FT CDS 39905..40321 FT /transl_table=11 FT /gene="Mb2042" FT /locus_tag="Mb2042" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2042, -, len: 138 aa. Equivalent to Rv2019, len: FT 138 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 138 aa overlap). Hypothetical protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZ54" FT /protein_id="CAD96895.1" FT /translation="MQPDRNLLADLDHIFVDRSLGAVQVPQLLRDAGFRLTTMREHYGE FT TQAQSVSDHKWIAMTAECGWIGFHKDANIRRNAVERRTVLDTGARLFCVPRADILAEQV FT AARYIASLAAIARAARFPGPFIYTVHPSKIVRVL" FT CDS complement(40337..40636) FT /transl_table=11 FT /gene="Mb2043c" FT /locus_tag="Mb2043c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2043c, -, len: 99 aa. Equivalent to Rv2020c, len: FT 99 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 99 aa overlap). Conserved hypothetical FT protein, nearly identical to C-terminal part of FT hypothetical protein RvD1-Rv2024c' from Mycobacterium bovis FT BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds to FT deletion region RvD1 so probably truncated protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZ53" FT /protein_id="CAD96896.1" FT /translation="MAPGMKWAAKTDHLAIVLLPRHHRRHSRRGRALPARSRSALGWII FT ERYRVTTDKASGIVNDPNDWCDEHDDPTYIVDLIKKVTTVSVETMKIVDGLAGG" FT CDS complement(40721..41026) FT /transl_table=11 FT /gene="Mb2044c" FT /locus_tag="Mb2044c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2044c, -, len: 101 aa. Equivalent to Rv2021c, len: FT 101 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 101 aa overlap). Unknown, possible FT regulatory protein similar to Mycobacterium tuberculosis FT hypothetical protein Rv3183, MTV014.27 (EMBL; AL021646). FT FASTA scores; TR:E12487 74 (109 aa) opt: 214 E(): 1.2e-09, FT 43.0% identity in 107 aa overlap. Contains probable FT helix-turn-helix at aa 45-66 (Score 1472, +4.20 SD)" FT /db_xref="GOA:Q7TZ52" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/TrEMBL:Q7TZ52" FT /protein_id="CAD96897.1" FT /translation="MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLT FT QVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYVSALGGELDITVRLGDETFTLA" FT CDS complement(41035..41640) FT /transl_table=11 FT /gene="Mb2045c" FT /locus_tag="Mb2045c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2045c, -, len: 201 aa. Equivalent to Rv2022c, len: FT 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 201 aa overlap). Conserved hypothetical FT protein, similar to Mycobacterium tuberculosis hypothetical FT protein Rv3182, MTV014.26 (EMBL:AL 021646). FASTA scores; FT TR:E1248773 (114 aa) opt: 335, E(): 3e-22, 53.8% identity FT in 106 aa overlap and to hypothetical proteins from FT Yersinia pestis (115 aa) e.g. emb|CAB53172.1| (AL109969), FT 41% identity in 108 aa overlap." FT /db_xref="InterPro:IPR018670" FT /db_xref="UniProtKB/TrEMBL:Q7TZ51" FT /protein_id="CAD96898.1" FT /translation="MNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHF FT LDGSPVARCSYPEEYHPCVISRIALLCDSVGWTADVERISAWLNGLDRETYELVFAAIE FT VLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAGNKA FT GRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG" FT CDS complement(41665..42024) FT /transl_table=11 FT /gene="Mb2046c" FT /locus_tag="Mb2046c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2046c, -, len: 119 aa. Equivalent to Rv2023c, len: FT 119 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 119 aa overlap). Hypothetical protein, FT alternative upstream start possible." FT /db_xref="UniProtKB/TrEMBL:Q7TZ50" FT /protein_id="CAD96899.1" FT /translation="MAARHARAGRWAAQPRPMLGSGAVRYEVGANIDATGFGGIAAVHR FT LVTRLGLVTRLGLVERVDAHSRFSSSNLPKSSRRISGRVSLSGMSNSAAKVVASTSSSP FT WGQPLSVGLRRRWRS" FT CDS complement(42184..42861) FT /transl_table=11 FT /gene="Mb2047c" FT /locus_tag="Mb2047c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2047c, -, len: 225 aa. No equivalent in FT Mycobacterium tuberculosis strain H37Rv, but equivalent to FT MT2080, len: 225 aa, from Mycobacterium tuberculosis strain FT CDC1551, (100.0% identity in 225 aa overlap). Hypothetical FT unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to FT the RvD1 region. Absent in Mycobacterium tuberculosis FT strain H37Rv." FT /db_xref="UniProtKB/TrEMBL:Q7TZ49" FT /protein_id="CAD96900.1" FT /translation="MVQRYPFRMVQRTPAMTSVAQLEHYLEEHLTKELAWLLRAATEWH FT AQHCMNLGIDGYSMQVYALDSTVLHARTLFEFFTQNTSVGQNANYYNCTVYKVPLIGSI FT LYQFHWRRPIHSHMMHAQDRRPVTQLPTYDDHAQTKPLNEMPVDFAKEIVRLWRVFVKD FT LNNHTNLQFRPIGATAQTALASEINAAKRVRTNDVTQRQIAVGKETSRLEPNFSIPQIE FT WPA" FT CDS complement(43256..44152) FT /transl_table=11 FT /gene="Mb2048c" FT /locus_tag="Mb2048c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2048c, -, len: 298 aa. No equivalent in FT Mycobacterium tuberculosis strain H37Rv, but equivalent to FT MT2081, len: 311 aa, from Mycobacterium tuberculosis strain FT CDC1551, (99.66% identity in 298 aa overlap). Hypothetical FT unknown protein. REMARK-M.bovis-M.tuberculosis: Belongs to FT the RvD1 region. Absent in Mycobacterium tuberculosis FT strain H37Rv." FT /db_xref="UniProtKB/TrEMBL:Q7TZ48" FT /protein_id="CAD96901.1" FT /translation="MTLIQTVTTDDLVIQVADRRLSRPDGSVFDDDYTKLVCWNTSFTV FT GFTGLARIDPAQKKSTSEWLAETLCDYASFEDGVDALRYWASGQIGQLPTGKGWEDKRL FT GIIIAGFDRRRIPLVAEISNFDPEAPIPANQNEFKCYRIRRAPGHSASFRITGAALTEK FT MYANILLRRVPRMLKQQDGITRAARLMVALQRRISEDNPGVGRHAMAVAIPRERTMPAV FT LSNLDAPSLNTMNSNFCYFDDAGFNYKQLGPHMAGGGWAWADFVAEADPSNPDMQKVGG FT RVLKCPQPPPQAESTGC" FT CDS complement(44336..49156) FT /transl_table=11 FT /gene="Mb2049c" FT /locus_tag="Mb2049c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2049c, RvD1-Rv2024c, len: 1606 aa. Equivalent to FT Rv2024c and similar to Rv2020c, len: 515 aa and 99 aa, from FT Mycobacterium tuberculosis strain H37Rv, (99.2% identity in FT 506 aa overlap and 67.0% identity in 97 aa overlap). FT Rv2024c: Conserved hypothetical protein. Identical to FT N-terminal part of much larger hypothetical protein, FT RvD1-Rv2024c' (1606 aa), from Mycobacterium bovis BCG: FT CAB44655.1|Y18605|13881753|AAK46361.1|AE007059 so probably FT truncated. Part of RvD1 chromosomal deletion region. Also FT similar to hypothetical protein from Helicobacter pylori. FT FASTA scores: AE0005|HPAE000580_2 Helicobacter pylori (607 FT aa) opt: 64, E(): 0, (36.2% identity in 464 aa overlap). FT Rv2020c: Conserved hypothetical protein, nearly identical FT to C-terminal part of hypothetical protein RvD1-Rv2024c' FT from Mycobacterium bovis BCG (1606 aa) emb|CAB44655.1| FT (Y18605). Corresponds to deletion region RvD1 so probably FT truncated protein. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, a large deletion FT region (RvD1) exists in between Rv2023 and Rv2024. In FT Mycobacterium bovis a 5000 bp insertion at this region FT results in Mb2049c being a much larger product with a FT different COOH part (1606 aa versus 515 aa)." FT /db_xref="GOA:Q7TZ47" FT /db_xref="InterPro:IPR002296" FT /db_xref="UniProtKB/TrEMBL:Q7TZ47" FT /protein_id="CAD96902.1" FT /translation="MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDAV FT WRWIDWPERRGRTDTGIDLVARERDTGNYTAIQCKFYEPTHTLAKGDIDSFFTASGKTG FT FTNRVIISTTDRWGRNAEDALADQLVPVQRIGMAEIAESPIDWDIAWPAGDLQVNLTPA FT KRHELRPHQQQAIDAVFRGFAVGNDRGKLIMACGTGKTFTALKIAERIAADNGGSARIL FT LLVPSISLLSQTLREWTAQSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTDARVLL FT HEMAHRRCAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLAGDDESN FT VVRVHDGQYLKAARRLYMTATPRIFTESIKDRADQHSAELVSMDDELTFGPEFHRLSFG FT EAVERGLLTDYKVMVLTVDQGVIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGT FT GIVAGEPPMRRAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLACSVRHVDGTFNA FT LVRNEQLAWLKGVVAEDECRILSNARCLSEGVDVPALDAVLFLNPRNSIVDVVQSVGRV FT MRKSPGKDYGYVILPVAVPEGVEPSAALADNKRFKVVWQVLNALRSHDERFDAMVNSIA FT LNVKPTKTGEGSDKLLGGHIGPTSDEAGPAVAEQLAMFSLSQWQEAIYARIVDKVGTRT FT YWEQWAADVADIAATLTTRIHALLGGADATAAAAFEQFLAGLRDNLNDSITPDDAISML FT SQHLITKPVFDALFAGHDFASHNPVSRAMQKMVDTVGGAGLEAETARLEGFYESVRRRA FT GEVTSAEGKQQVIAELYEKFFRIGFKKQAEALGIVYTPVEVVDFIVRAADFVSRKHFGR FT GLTDEGVHILDGFAGTGTFITRLLQSDLITAADLTRKYSQELHANEIMLLAYYIAAVNI FT ESTYHALAGKTADADAYEPFPGMALADTFQISEAGDSMDAIMFPYNNARILRQLATPIS FT VIIGNPPYSVGQSSANDLNANVKYPTLDGRIEQTYAKRSTAQLKNSLYDSYIRAFRWAT FT DRIGDNGVVGFVSNGGYIDGNTADGMRLSLADDYAAVYVYNLRGNQRTAGELSRQEGGK FT VFGGGSRNTVAIFLGIKDPKHSGPCDVLYRDIGDYLSREEKLRIVGDGYLDTVEWQTVT FT PNLHGDWVNQRDDAFSAWPVIGDKKAALDVTRVFANYSAGLKTSRDAWCYNFSRGALEA FT NIGRTIDFYNSEVDRINEIRGRDAKTPPVDALITVDSAKFSWDRINKRQVAQGIRIEFA FT PAGMRLGTYRPFTKEHAYLDPNQQLNNCTYQLPSMFPTPEHGNVGYYVVGMGSDKPFSC FT LMLNAIPDLAFWGSSNGQFFPRWTYEKTEPRDGELDFESTTNAEVDDHGYRRVDNITGV FT ILKLYRDTIGDQVTKDDIFYYVYGLLHDPAYRTKYAADLKKMLPHIPTPETRERFDQLA FT SAGRKLADLHVGYESVKPYPLDVQLKPGADPEDRETWRVEKMKWKSKQDHSTIIYNSRV FT TIAGIPDEAERYLLGSRSALGWIIDRYRVTTDKASGIVNDPNDWCDEHANPTYIVDLIK FT KVTTVSVETMKIVDSIVALASAGSDST" FT CDS complement(49664..50662) FT /transl_table=11 FT /gene="Mb2050c" FT /locus_tag="Mb2050c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb2050c, -, len: 332 aa. Equivalent to Rv2025c, len: FT 332 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 332 aa overlap). Possible conserved FT transmembrane protein, CDF family possibly involved in FT transport of metal ions, similar to several hypothetical FT bacterial proteins e. g. Methanobacterium FT thermoautotrophicum AE000941_1 (298 aa; described as cation FT efflux system protein) and Archaeoglob us fulgidus FT AE001111_5 (384 aa). FASTA scores: AE000941_1 M FT ethanobacterium thermoautotrophicum (298 aa) opt: 452 E(): FT 3.3e-24; 30.8% identity in 266 aa overlap and AE001111_5 FT Archaeoglobus fulgidus section 16 (384 aa) opt: 371 E(): FT 1.7e-18; 27.7% identity in 267 aa overlap. TBparse score is FT 0.897" FT /db_xref="GOA:Q7TZ46" FT /db_xref="InterPro:IPR002524" FT /db_xref="UniProtKB/TrEMBL:Q7TZ46" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96903.1" FT /translation="MTHDHAHSRGVPAMIKEIFAPHSHDAADSVDDTLESTAAGIRTVK FT ISLLVLGLTALIQIVIVVMSGSVALAADTIHNFADALTAVPLWIAFALGAKPATRRYTY FT GFGRVEDLAGSFVVAMITMSAIIAGYEAIARLIHPQQIEHVGWVALAGLVGFIGNEWVA FT LYRIRVGHRIGSAALIADGLHARTDGFTSLAVLCSAGGVALGFPLADPIVGLLITAAIL FT AVLRTAARDVFRRLLDGVDPAMVDAAEQALAARPGVQAVRSVRMRWIGHRLHADAELDV FT DPALDLAQAHRIAHDAEHELTHTVPKLTTALIHAYPAEHGSSIPDRGRTVE" FT CDS complement(50777..51661) FT /transl_table=11 FT /gene="Mb2051c" FT /locus_tag="Mb2051c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2051c, -, len: 294 aa. Equivalent to Rv2026c, len: FT 294 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 294 aa overlap). Conserved hypothetical FT protein, very similar to Mycobacterium tuberculosis FT hypothetical proteins Rv2005c, Rv2623, Rv1996, Rv2624c, FT Rv2028c, Rv3134c, Rv1636. Some, possibly all, of these FT belong to universal stress protein family." FT /db_xref="GOA:Q7TZ45" FT /db_xref="InterPro:IPR006015" FT /db_xref="UniProtKB/TrEMBL:Q7TZ45" FT /protein_id="CAD96904.1" FT /translation="MSAATAKYGILVGVDGSAQSNAAVAWAAREAVMRQLPITLLHIVA FT PVVVGWPVGQLYANMTEWQKDNAQQVIEQAREALTNSLGESKPPQVHTELVFSNVVPTL FT IDASQQAWLMVVGSQGMGALGRLLLGSISTALLHHARCPVAIIHSGNGATPDSDAPVLV FT GIDGSPASEAATALAFDEASRRRVDLVALHAWTDLGMFPVLGMDWREREKREAEVLAER FT LAGWQEQYPDVRVHRSLVCDKPARWLLEHSEQAQLVVVGSHGRGGFSGMLLGSVSSAVA FT HSVRIPVIVVRPS" FT CDS complement(51701..53422) FT /transl_table=11 FT /gene="Mb2052c" FT /locus_tag="Mb2052c" FT /product="histidine kinase response regulator" FT /note="Mb2052c, -, len: 573 aa. Equivalent to Rv2027c, len: FT 573 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 573 aa overlap). Membrane protein FT related to histidine kinase response regulators. Highly FT similar to Mycobacterium tuberculosis protein Rv3132c, FT MTCY03A2.2 6. FASTA scores: Z83867|MTCY3A2_26 (578 aa) opt: FT 2330, E(): 0; 62.5% identity in 560 aa overlap." FT /db_xref="GOA:Q7VET1" FT /db_xref="InterPro:IPR003018" FT /db_xref="UniProtKB/TrEMBL:Q7VET1" FT /protein_id="CAD96905.1" FT /translation="MTHPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVEGRDR FT LDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEE FT TRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDE FT VFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGT FT QMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAV FT KQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALR FT SADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRL FT FAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLD FT KVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVE FT DDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR" FT CDS complement(53483..54322) FT /transl_table=11 FT /gene="Mb2053c" FT /locus_tag="Mb2053c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2053c, -, len: 279 aa. Equivalent to Rv2028c, len: FT 279 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 279 aa overlap). Conserved hypothetical FT protein, highly similar to Mycobacterium tuberculosis FT proteins Rv2005c, Rv2623, Rv1996, Rv2624c, Rv3134c, Rv1636. FT Some, possibly all, of these belong to universal stress FT protein family. Rv2624c|MTCY01A10.08 (272 aa) and FT Rv3134c|MTCY03A2.24 (268 aa). FASTA scores: FT Z95387|MTCY1A10_8 (272 aa) opt: 563, E(): 2.5e-31, (36.8% FT identity in 266 aa overlap) and Z83867|MTCY3A2_24 (268 aa) FT opt: 562, E(): 2.9e-31, (40.7% identity in 273 aa FT overlap)." FT /db_xref="GOA:Q7TZ44" FT /db_xref="InterPro:IPR006015" FT /db_xref="UniProtKB/TrEMBL:Q7TZ44" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96906.1" FT /translation="MNQSHKPPSIVVGIDGSKPAVQAALWAVDEAASRDIPLRLLYAIE FT PDDPGYAAHGAAARKLAAAENAVRYAFTAVEAADRPVKVEVEITQERPVTSLIRASAAA FT ALVCVGAIGVHHFRPERVGSTAAALALSAQCPVAIVRPHRVPIGRDAAWIVVEADGSSD FT IGVLLGAVMAEARLRDSPVRVVTCRQSGVGDTGDDVRASLDRWLARWQPRYPDVRVQSA FT AVHGELLDYLAGLGRSVHMVVLSASDQEHVEQLVGAPGNAVLQEAGCTLLVVGQQYL" FT CDS complement(54319..55338) FT /transl_table=11 FT /gene="pfkB" FT /locus_tag="Mb2054c" FT /product="Probable phosphofructokinase pfkB FT (PHOSPHOHEXOKINASE)" FT /EC_number="2.7.1.-" FT /note="Mb2054c, pfkB, len: 339 aa. Equivalent to Rv2029c, FT len: 339 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 339 aa overlap). Probable pfkB, FT phosphofructokinase (EC 2.7.1.-), similar to others eg FT P06999|K6P2_ECOLI 6-PHOSPHOFRUCTOKINASE I SOZYME 2 from E. FT coli (309 aa), FASTA scores: opt: 705, E(): 0; (41.4% FT identity in 304 aa overlap); and LACC_STRMU FT phosphotagatosekinase (310 aa); etc. Contains PS00583 pfkB FT family of carbohydrate kinases signature 1." FT /db_xref="GOA:Q7TZ43" FT /db_xref="InterPro:IPR011611" FT /db_xref="UniProtKB/TrEMBL:Q7TZ43" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96907.1" FT /translation="MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPRY FT DPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIPIAASTRESFT FT VNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVASGSLPPGVAADYYQRV FT ADICRRSSTPLILDTSGGGLQHISSGVFLLKASVRELRECVGSELLTEPEQLAAAHELI FT DRGRAEVVVVSLGSQGALLATRHASHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSL FT IKSVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP" FT CDS complement(55355..55594) FT /transl_table=11 FT /gene="Mb2055c" FT /locus_tag="Mb2055c" FT /product="CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]" FT /note="Mb2055c, -, len: 79 aa. Equivalent to 3' end of FT Rv2030c, len: 681 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.000% identity in 79 aa overlap). FT Conserved hypothetical protein that corresponds to products FT of two adjacent ORF's described previously MSGTUBDWN_4 (390 FT aa) and MSGTUBDWN_1 (385 aa). Also similar to C-terminal FT two-thirds of Mycobacterium tuberculosis protein Rv2143 FT (MTCY270.25c; 352 aa) and to Rv0571c (443 aa) and FT Mycobacterium leprae protein U650s MLU15184_16 (258 aa). FT FASTA scores: M93129|MSGTUBDWN_4 (390 aa) opt: 2530 E(): 0; FT 97.7% identity in 385 aa overlap and M93129|MSGTUBDWN_1 FT (385 aa) opt: 1983 E(): 0; 99.0% identity in 309 aa FT overlap. Z95388| MTCY270_25 (352 aa) opt: 882 E(): 0; 61.1 FT % identity in 226 aa overlap. U15184|MLU15184_16 (258 aa) FT opt: 549 E(): 9.8e-29; 43.8% identity in 219 aa overlap. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv2030c exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT deletion (c-*) splits Rv2030c into 2 parts, Mb2055c and FT Mb2056c." FT /db_xref="GOA:Q7TZ42" FT /db_xref="InterPro:IPR007815" FT /db_xref="UniProtKB/TrEMBL:Q7TZ42" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96908.1" FT /translation="MSARLSRDAEAPLDVVRLGRAIGVVYLPATERQSHYLHVRPADQF FT DAMIHIDQTRALEPLEVTSRWIAGENPETYPTGL" FT CDS complement(55579..57399) FT /transl_table=11 FT /gene="Mb2056c" FT /locus_tag="Mb2056c" FT /product="CONSERVED HYPOTHETICAL PROTEIN [FIRST PART]" FT /note="Mb2056c, -, len: 606 aa. Equivalent to 5' end of FT Rv2030c, len: 681 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 587 aa overlap). FT Conserved hypothetical protein that corresponds to products FT of two adjacent ORF's described previously MSGTUBDWN_4 (390 FT aa) and MSGTUBDWN_1 (385 aa). Also similar to C-terminal FT two-thirds of Mycobacterium tuberculosis protein Rv2143 FT (MTCY270.25c; 352 aa) and to Rv0571c (443 aa) and FT Mycobacterium leprae protein U650s MLU15184_16 (258 aa). FT FASTA scores: M93129|MSGTUBDWN_4 (390 aa) opt: 2530 E(): 0; FT 97.7% identity in 385 aa overlap and M93129|MSGTUBDWN_1 FT (385 aa) opt: 1983 E(): 0; 99.0% identity in 309 aa FT overlap. Z95388| MTCY270_25 (352 aa) opt: 882 E(): 0; 61.1 FT % identity in 226 aa overlap. U15184|MLU15184_16 (258 aa) FT opt: 549 E(): 9.8e-29; 43.8% identity in 219 aa overlap. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv2030c exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT deletion (g-*) splits Rv2030c into 2 parts, Mb2055c and FT Mb2056c." FT /db_xref="GOA:Q7TZ41" FT /db_xref="InterPro:IPR007815" FT /db_xref="UniProtKB/TrEMBL:Q7TZ41" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96909.1" FT /translation="MLMTAAADVTRRSPRRVFRDRREAGRVLAELLAAYRDQPDVIVLG FT LARGGLPVAWEVAAALHAPLDAFVVRKLGAPGHDEFAVGALASGGRVVVNDDVVRGLRI FT TPQQLRDIAEREGRELLRRESAYRGERPPTDITGKTVIVVDDGLATGASMFAAVQALRD FT AQPAQIVIAVPAAPESTCREFAGLVDDVVCATMPTPFLAVGESFWDFRQVTDEEVRRLL FT ATPTAGPSLRRPAASTAADVLRRVAIDAPGGVPTHEVLAELVGDARIVLIGESSHGTHE FT FYQARAAMTQWLIEEKGFGAVAAEADWPDAYRVNRYVRGLGEDTNADEALSGFERFPAW FT MWRNTVVRDFVEWLRTRNQRYESGALRQAGFYGLDLYSLHRSIQEVISYLDKVDPRAAA FT RARARYACFDHACADDGQAYGFAAAFGAGPSCEREAVEQLVDVQRNALAYARQDGLLAE FT DELFYAQQNAQTVRDAEVYYRAMFSGRVTSWNLRDQHMAQTLGSLLTHLDRHLDAPPAR FT IVVWAHNSHVGDARATEVWADGQLTLGQIVRERYGDESRSIGFSTYTGTVTAASEWGGI FT AQRKAVRPALHAVSRSSSTRLQTVSWCQRG" FT CDS complement(57411..57845) FT /transl_table=11 FT /gene="hspX" FT /locus_tag="Mb2057c" FT /standard_name="acr" FT /product="HEAT SHOCK PROTEIN HSPX (ALPHA-CRSTALLIN HOMOLOG) FT (14 kDa ANTIGEN) (HSP16.3)" FT /note="Mb2057c, hspX, len: 144 aa. Equivalent to Rv2031c, FT len: 144 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 144 aa overlap). hspX, heat shock FT protein localized in the inner membrane (see citations FT below). Identical to P30223|14KD_MYCTU 14 KD ANTIGEN (16 FT kDa ANTIGEN) (HSP 16.3) of Mycobacterium tuberculosis (143 FT aa), FASTA scores: opt: 933, E(): 0, (100.0% identity in FT 143 aa overlap). BELONGS TO THE SMALL HEAT SHOCK PROTEIN FT (HSP20) FAMILY. Also known as alpha-crystallin and gene as FT acr (see some citations below). TBparse score is 0.897." FT /db_xref="GOA:P0A5B8" FT /db_xref="InterPro:IPR002068" FT /db_xref="UniProtKB/Swiss-Prot:P0A5B8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96910.1" FT /translation="MATTLPVQRHPRSLFPEFSELFAAFPSFAGLRPTFDTRLMRLEDE FT MKEGRYEVRAELPGVDPDKDVDIMVRDGQLTIKAERTEQKDFDGRSEFAYGSFVRTVSL FT PVGADEDDIKATYDKGILTVSVAVSEGKPTEKHIQIRSTN" FT CDS 58042..59037 FT /transl_table=11 FT /gene="Mb2058" FT /locus_tag="Mb2058" FT /product="Conserved hypothetical protein Acg" FT /note="Mb2058, -, len: 331 aa. Equivalent to Rv2032, len: FT 331 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 331 aa overlap). acg (for FT acr-coregulated gene), conserved hypothetical protein FT possibly member of a superfamily of classical FT nitroreductases (see first citation below), similar to FT hypothetical mycobacterial proteins Rv3127|MTCY164.37 (344 FT aa) and Rv3131|MTCY03A2.27c (332 aa). FASTA scores: FT Z95150|MTCY164_38 Mycobacterium tuberculosis cosmid (344 FT aa) opt: 1208, E(): 0, (56.4% identity in 321 aa overlap); FT Z83867| MTCY3A2_27 Mycobacterium tuberculosis cosmid (332 FT aa) opt: 568, E(): 8.6e-30, (36.8% identity in 321 aa FT overlap). Similar to proteins SCJ1.11 (330 aa; AL109962) FT and SCJ12.27c (335 aa; AL109989) in Streptomyces FT coelicolor." FT /db_xref="GOA:Q7VET0" FT /db_xref="InterPro:IPR000415" FT /db_xref="UniProtKB/TrEMBL:Q7VET0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96911.1" FT /translation="MPDTMVTTDVIKSAVQLACRAPSLHNSQPWRWIAEDHTVALFLDK FT DRVLYATDHSGREALLGCGAVLDHFRVAMAAAGTTANVERFPNPNDPLHLASIDFSPAD FT FVTEGHRLRADAILLRRTDRLPFAEPPDWDLVESQLRTTVTADTVRIDVIADDMRPELA FT AASKLTESLRLYDSSYHAELFWWTGAFETSEGIPHSSLVSAAESDRVTFGRDFPVVANT FT DRRPEFGHDRSKVLVLSTYDNERASLLRCGEMLSAVLLDATMAGLATCTLTHITELHAS FT RDLVAALIGQPATPQALVRVGLAPEMEEPPPATPRRLIDEVFHVRAKDHR" FT CDS complement(59153..59995) FT /transl_table=11 FT /gene="Mb2059c" FT /locus_tag="Mb2059c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2059c, -, len: 280 aa. Equivalent to Rv2033c, len: FT 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 280 aa overlap). Conserved hypothetical FT protein, similar to hypothetical protein SCC77.24 (274 aa) FT from Streptomyces coelicolor A3(2) CAB66235.1|AL13650) (50% FT identity in 261 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZ40" FT /protein_id="CAD96912.1" FT /translation="MLDRYGTDVLAAGGRRRPRSVEHPVELGMVVEDAETGYVGAVVRV FT EYGRIDLEDRYGKTRGFPLGPGYLLDGLPVILTAPRCAAAAGPRRTASGSVAVPGARAR FT VARASRIYVEGRHDAELIAAVWGADLRIEGVVVEHLGGVDDLVEIVAKFRPGPRRRLGV FT LVDHLVAGSKEARIAEVVRRGPGGSDTLVVGHPYVDIWQAVKPQRVGLAAWPRVPRHIE FT WKHGVCDALGWPHADQADIAAAWRRIRSQVRDWTDLEPALIGRVEELIDFVTQPAGDE" FT CDS 60207..60530 FT /transl_table=11 FT /gene="Mb2060" FT /locus_tag="Mb2060" FT /product="Probable ArsR-type repressor protein" FT /note="Mb2060, -, len: 107 aa. Equivalent to Rv2034, len: FT 107 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 107 aa overlap). Probable repressor FT protein similar to several belonging to the ARSR FAMILY FT e.g. Q53040 (112 aa). FASTA scores: sptr|Q53040|Q53040 FT NITRILE HYDRATASE REGULATAR 2 (112 aa) opt: 167, E( ): FT 6.7e-06; 44.7% identity in 76 aa overlap. TBparse score is FT 0.905. Contains probable helix-turn-helix at aa 32-53 (S FT core 1350, +3.78 SD)" FT /db_xref="GOA:Q7VES9" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:Q7VES9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96913.1" FT /translation="MSTYRSPDRAWQALADGTRRAIVERLAHGPLAVGELARDLPVSRP FT AVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAALRTDLDRFWTRALTGYAQLIDSEG FT DDT" FT CDS 60527..61015 FT /transl_table=11 FT /gene="Mb2061" FT /locus_tag="Mb2061" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2061, -, len: 162 aa. Equivalent to Rv2035, len: FT 162 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 162 aa overlap). Conserved hypothetical FT protein, similar to conserved hypothetical protein (156 aa) FT from Sinorhizobium meliloti CAC46569.1|AL591789 (34% FT identity in 146 aa overlap)." FT /db_xref="GOA:Q7TZ39" FT /db_xref="InterPro:IPR013538" FT /db_xref="UniProtKB/TrEMBL:Q7TZ39" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96914.1" FT /translation="MTRPRTDAIHHHVVVNAPIERAFAVFTTRFGDFKPREHNLLAIPI FT TETVFECHAGGHIYDRGVDGSVCKWARVLVYEPPSRVLFTWDIGPTWRPETDLAKTSEV FT EVRFTAQSAETTRVDLEHRHLDRHGPGWESVADGVDSEAGWPLYLRRYTDLLCIQVQP" FT CDS 61012..61653 FT /transl_table=11 FT /gene="Mb2062" FT /locus_tag="Mb2062" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2062, -, len: 213 aa. Equivalent to Rv2036, len: FT 213 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 213 aa overlap). Conserved hypothetical FT protein; slight similarity to Streptomyces lincolnensis FT protein involved in lincomycin production Q54375 (238 aa). FT FASTA scores: sptr|Q54375|Q54375 (78-11) LINCOMYCIN FT PRODUCTION GENES (238 aa) opt: 119, E(): 0.97; 31.3% FT identity in 99 aa overlap. TBparse score is 0.934" FT /db_xref="InterPro:IPR017517" FT /db_xref="UniProtKB/TrEMBL:Q7TZ38" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96915.1" FT /translation="MIAADDDTEKSMMDMARAERAELAAFLTTLTLQQWETPSLCAGWS FT VKEVVAHMISYEDLGVFGLLKRFAKGRIVRANEVGVDEFAGLSPQELVDYVGRHLQPRG FT LTAGFGGMIALVDGMIHHQDIRRPLGQPRTIPAQRLDRVLRLMPKNPRLRARPRIKGLR FT LRATDLDWTIGTGPEVTGPGEALLMAMAGRPAAVSDLSGPGKPTLAGRLG" FT CDS complement(61660..62634) FT /transl_table=11 FT /gene="Mb2063c" FT /locus_tag="Mb2063c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb2063c, -, len: 324 aa. Equivalent to Rv2037c, len: FT 324 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 324 aa overlap). Possible conserved FT transmembrane protein, similar to hypothetical proteins FT from Mycobacterium leprae MLCB2052.31 (329 aa) and Bacillus FT subtilis P54513|YQHO_BACSU (291 aa). FASTA scores: FT Z98604|MLCB2052_1 6 Mycobacterium leprae cosmid B205 (329 FT aa) opt: 1764, E(): 0; 80.5% identity in 323 aa overlap and FT sp|P54513|YQHO_BACSU HYPOTHETICAL 32.9 KD PROTEIN IN G (291 FT aa ) opt: 328, E(): 8.8e-14; 36.6% identity in 306 aa FT overlap. TBparse score is 0.919" FT /db_xref="GOA:Q7TZ37" FT /db_xref="InterPro:IPR002641" FT /db_xref="UniProtKB/TrEMBL:Q7TZ37" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96916.1" FT /translation="MALVSTARVDLVCEGGGVRGIGLVGAVDALADAGYRFPRVAGSSA FT GAIVASLVAALQTAGEPVTRLAEMMRSIDYPKFLDRNLIGHVPLIGGGLSLLLSDGVYR FT GAYLEQLLGGLLADLGVHTFGDLRTGEAPEQFAWSLVVTASDLSRRRLVRIPWDLDSYG FT IHPDDFSVARAVHASSAIPFVFEPVRVRGATWVDGGLLSNFPVALFDRTDAEPRWPTFG FT IRLSARPGIPPTRPVQGPVSLGIAAIETLVSNQDNAYIDDPCTVRRTIFVPAHDVSPID FT FDITAEQREALYQRGFQAGQKFLANWNYADYLADCGGPFTPSL" FT CDS complement(62636..63709) FT /transl_table=11 FT /gene="Mb2064c" FT /locus_tag="Mb2064c" FT /product="Probable sugar-transport ATP-binding protein ABC FT transporter" FT /note="Mb2064c, -, len: 357 aa. Equivalent to Rv2038c, len: FT 357 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 357 aa overlap). Probable FT sugar-transport ATP-binding protein ABC transporter (see FT citation below), equivalent to FT MLCB2052.30|Z98604|MLCB2052_15 from Mycobacterium leprae FT (356 aa), FASTA scores: opt: 1866, E(): 0, (79.7% identity FT in 355 aa overlap). Also similar to multiple sugar import FT proteins e.g. Y08921|SRMSIK_1 msiK protein from FT Streptomyces reticuli (377 aa), FASTA scores: opt: 1336, FT E(): 0, (62.6% identity in 377 aa overlap); etc. Also FT similar to several proteins from Mycobacterium tuberculosis FT e.g. Rv2832c, Rv1238, Rv2397c, Rv3758c. Contains PS00211 FT ABC transporters family signature and PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7VES8" FT /db_xref="HSSP:1G29" FT /db_xref="InterPro:IPR013611" FT /db_xref="UniProtKB/TrEMBL:Q7VES8" FT /protein_id="CAD96917.1" FT /translation="MASVSFEQATRRYPGTDRPALDRLDLIVGDGEFVVLVGPSGCGKT FT TSLRMVAGLETLDCGRIRIGERDVTEVDPKDRDVAMVFQNYALYPHMTVAQNMGFALKV FT AKIGKAEIRERVLAAAKLLDLQSYLDRKPKDLSGGQRQRVAMGRAIVRRPQVFLMDEPL FT SNLDAKLRGQTRNQIAALQRQLGTTTVYVTHDQVEAMTMGDRVAVLSDGVLQQCASPRE FT LYRNPGNVFVAGFIGSPAMNLFRLSIADSTVSLGDWQILLPRAVVGTAAEVIIGVRPEH FT LELGGAGIEMDVDMVEELGADAYLYGRIVSGGCEMDQSIVARVDGRGPPERGSRVRLCP FT TPGHLHFFAVDGRRIPG" FT CDS complement(63712..64554) FT /transl_table=11 FT /gene="Mb2065c" FT /locus_tag="Mb2065c" FT /product="Probable sugar-transport integral membrane FT protein ABC transporter" FT /note="Mb2065c, -, len: 280 aa. Equivalent to Rv2039c, len: FT 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 280 aa overlap). Probable FT sugar-transport integral membrane protein ABC transporter FT (see citation below), equivalent to FT MLCB2052.29|Z98604|MLCB2052_14 from Mycobacterium leprae FT (283 aa), FASTA scores: opt: 1593, E(): 0, (79.2% identity FT in 283 aa overlap). Also similar to maltose and lactose FT transport proteins e.g. X66092|CPMALGHOM_1 from C. FT perfringens (275 aa), FASTA scores: opt: 695, E(): 0, FT (41.2% identity in 228 aa overlap); etc. Contains PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp signature. Also contains possible helix-turn-helix FT motif at aa 171-192, although this is probably fortuitous." FT /db_xref="GOA:Q7VES7" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q7VES7" FT /protein_id="CAD96918.1" FT /translation="MGWADRIVHRHFIRGLALYAGLIGIAWCALFPIIWALSGSLKADG FT EVTEPTLFPSHPQWSNYREVFALMPFWRMFFNTVLYAGCVTAGQVFFCSLAGYAFARLQ FT FRGRDTLFVLYLSTLMVPLTVTVIPQFILMRIVGWVDTPWAMIVPGLFGSAFGTYLMRQ FT FFRTLPTDLEEAAILDGCSPWQIYWRILLPHSRPAVLVLGVLTWVNVWNDFLWPLLMIQ FT RNSLATLTLGLVRLRGEYVARWPVLMAASMLMLVPLVILYAVAQRSFVRGIAVTGLGG" FT CDS complement(64541..65443) FT /transl_table=11 FT /gene="Mb2066c" FT /locus_tag="Mb2066c" FT /product="Probable sugar-transport integral membrane FT protein ABC transporter" FT /note="Mb2066c, -, len: 300 aa. Equivalent to Rv2040c, len: FT 300 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 300 aa overlap). Probable FT sugar-transport integral membrane protein ABC transporter FT (see citation below), equivalent to FT MLCB2052.28|Z98604|MLCB2052_13 from Mycobacterium leprae FT (319 aa), FASTA scores: opt: 1606, E(): 0, (81.6% identity FT in 293 aa overlap). Also similar to many diverse sugar FT transport proteins." FT /db_xref="GOA:Q7VES6" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q7VES6" FT /protein_id="CAD96919.1" FT /translation="MTRRRGRRAWAGRMFVAPNLAAVVVFMLFPLGFSLYMSFQKWDLF FT THATFVRLDNFRNLFTSDPLFLIAVVNTAVYTVGTVVPTVIVSLVVAAFLNRKIKGISL FT FRTVVFLPLAISSVVMAVVWQFVFNTDNGLLNIMLGWLGIGPIPWLIEPRWAMVSLCLV FT SVWRSVPFATVVLLAAMQGVPETVYEAARIDGAGEIRQFVSITVPLIRGALSFVVVISI FT IHAFQAFDLVYVLTGANGGPETATYVLGIMLFQHAFSFLEFGYASALAWVMFAILLVLT FT VLQLRITHRRSWEASRGLG" FT CDS complement(65440..66759) FT /transl_table=11 FT /gene="Mb2067c" FT /locus_tag="Mb2067c" FT /product="Probable sugar-binding lipoprotein" FT /note="Mb2067c, -, len: 439 aa. Equivalent to Rv2041c, len: FT 439 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 439 aa overlap). Probable sugar-binding FT lipoprotein component of sugar transport system, equivalent FT to Z98604|MLCB2052_1|MLCB2052.27 from Mycobacterium leprae FT (445 aa), FASTA scores: opt: 2324, E(): 0, (77.4% identity FT in 446 aa overlap). Contains signal sequence and FT appropriately positioned PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="GOA:Q7VES5" FT /db_xref="InterPro:IPR019546" FT /db_xref="UniProtKB/TrEMBL:Q7VES5" FT /protein_id="CAD96920.1" FT /translation="MVNKPFERRSLLRGAGALTAASLAPWAAGCAADDDDALTFFFAAN FT PDELRPRMRVVNEFQRRYPDIKVRALLSGPGVMQQLATFCAGGKCPDVLMAWELTYAEL FT ADRGVLLDLNTLLARDQVFAAELKSDSIGALYETFTFNGGQYAFPEQWSGNFLFYNKQL FT FDDAGVPPPPGSWERPWSFAEFLDAAQALTKQGRSGRDRQWGFVNAWVSFYAAGLFAMN FT NGVPWSVPRMNPTHLNFDHDGFLEAVQFYADLTNKHKVAPSAAEQQSMSTADLFSVGKA FT GIALAGHWRYQTFDRADGLDFDVAPLPIGPRGRAACSDIGVTGLAIAATSRRKDQAWEF FT VKFATGPVGQALIGESRLFVPVLRSAINSHGFANAHRRVGNLAVLSEGPAYSEGLPVTP FT AWEKIAALMDRYFGPVLRGSRPATSLTGLSQAVDEVLRNP" FT CDS complement(66797..67594) FT /transl_table=11 FT /gene="Mb2068c" FT /locus_tag="Mb2068c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2068c, -, len: 265 aa. Equivalent to Rv2042c, len: FT 265 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 265 aa overlap). Conserved hypothetical FT protein,similar in N-terminal part to hypothetical proteins FT MLCB2052.24 (95 aa) and Rv0760c|MTCY369.05 (139 aa). FASTA FT scores: Z98604|MLCB2052_9 Mycobacterium leprae cosmid B2052 FT (95 aa) opt: 269, E(): 2.9e-12, (55.4% identity in 92 aa FT overlap) and Z80226|MTCY369_5 Mycobacterium tuberculosis FT cosmid (139 aa) opt: 150, E(): 0.001, (28.7% identity in FT 136 aa overlap)." FT /db_xref="GOA:Q7TZ36" FT /db_xref="HSSP:1ISK" FT /db_xref="InterPro:IPR002075" FT /db_xref="UniProtKB/TrEMBL:Q7TZ36" FT /protein_id="CAD96921.1" FT /translation="MAPPNRDELLAAVERSPQAAAAHDRAGWVGLFTGDARVEDPVGSQ FT PQVGHEAIGRFYDTFIGPRDITFHRDLDIVSGTVVLRDLELEVAMDSAVTVFIPAFLRY FT DLRPVTGEWQIAALRAYWELPAMMLQFLRTGSGATRPALQLSRALLGNQGLGGTAGFLT FT GFRRAGRRHKKLVETFLNAASRADKSAAYHALSRTATMTLGEDELLDIVELFEQLRGAS FT WTKVTGAGSTVAVSLASDHRRGIMFADVPWRGNRINRIRYFPA" FT CDS complement(67594..68154) FT /transl_table=11 FT /gene="pncA" FT /locus_tag="Mb2069c" FT /product="PYRAZINAMIDASE/NICOTINAMIDAS PNCA (PZase)" FT /EC_number="3.5.1.-" FT /note="Mb2069c, pncA, len: 186 aa. Equivalent to Rv2043c, FT len: 186 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 186 aa overlap). pncA, FT pyrazinamidase/nicotinamidase (EC 3.5.1.-) (see citations FT below). Identical to PYRAZINAMIDASE/NICOTINAMIDASE involved FT in susceptibility or resistance to antituberculous drug FT pyrazinamide. FASTA scores: sptr|Q50575|Q50575 FT PYRAZINAMIDASE/NICOTINAMIDASE. (186 aa) opt: 1236, E(): 0; FT 100.0% identity in 186 aa overlap." FT /db_xref="GOA:Q93SP7" FT /db_xref="HSSP:1ILW" FT /db_xref="InterPro:IPR000868" FT /db_xref="UniProtKB/TrEMBL:Q93SP7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96922.1" FT /translation="MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVV FT ATKDFHIDPGDDFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYS FT GFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLTAGV FT SADTTVAALEEMRTASVELVCSS" FT CDS complement(68195..68512) FT /transl_table=11 FT /gene="Mb2070c" FT /locus_tag="Mb2070c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2070c, -, len: 105 aa. Equivalent to Rv2044c, len: FT 105 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 105 aa overlap). Conserved hypothetical FT protein, similar to conserved hypothetical protein PA3386 FT (121 aa) from Pseudomonas aeruginosa |E83221 conserved FT hypothetical protein PA3386 [imported] - Pseudomonas FT aeruginosa (strain PAO1) 9949522|gb|AAG06774.1|AE004760_2 FT (AE004760). (46% identity in 92 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZ35" FT /protein_id="CAD96923.1" FT /translation="MHFAFIAYVLAGGFLALRWRRTMWLHVPAVIWGIGIAAKRVDCPL FT TWVERWARTKAAMTPLSPDGFVAHYITGVIYPAGWVAAAQLVMFAIVAASWTLYLWLPR FT R" FT CDS complement(68598..70133) FT /transl_table=11 FT /gene="lipT" FT /locus_tag="Mb2071c" FT /product="Probable carboxylesterase LipT" FT /EC_number="3.1.1.-" FT /note="Mb2071c, lipT, len: 511 aa. Equivalent to Rv2045c, FT len: 511 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 511 aa overlap). Probable lipT, FT carboxylesterase similar to many e.g. O08472 (489 aa) and FT P37967|PNBA_ BACSU (489 aa). PARA-NITROBENZYL ESTERASE (EC FT 3.1.1.-). Contains PS00941 Carboxylesterases type-B FT signature 2. Contains PS00122 Carboxylesterases type-B FT serine active site. FASTA scores: sptr|O08472|O08472 FT INTRACELLULAR ESTERASE B (489 aa) opt: 849, E(): 0, (36.2% FT identity in 489 aa overlap) and sp|P37967|PNBA_BACSU FT PARA-NITROBENZYL ESTERASE (489 aa) opt: 838, E(): 0, (36.0% FT identity in 489 aa overlap). TBparse score is 0 .918" FT /db_xref="GOA:Q7VES4" FT /db_xref="HSSP:1F8U" FT /db_xref="InterPro:IPR002168" FT /db_xref="UniProtKB/TrEMBL:Q7VES4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96924.1" FT /translation="MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARAP FT VGSLRFRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPEE FT PATQPLPVMVFIHGGGYILGSSATPIYDGAALARRGCVYVSVNYRLGALGCLDLSSLST FT PQITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPAAKGL FT FARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQASPAQLVEAQHHLIR FT QGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTRFLGMLP FT TNEPMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAP FT TYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALRVSNEVQR FT RWRCFSQIGVPGDDWPAYTQDDRAVLVFDRRCRIEFDPHQHRRIAWDGFSLAN" FT CDS 70182..70838 FT /transl_table=11 FT /gene="lppI" FT /locus_tag="Mb2072" FT /product="Probable lipoprotein lppI" FT /note="Mb2072, lppI, len: 218 aa. Equivalent to Rv2046, FT len: 218 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 218 aa overlap). Probable lppI, FT lipoprotein contains signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="UniProtKB/TrEMBL:Q7VES3" FT /protein_id="CAD96925.1" FT /translation="MRIAALVAVSLLIAGCPREVGGDVGQSQTIAPPAPAPSAAPSTPP FT AAGAPITTIVSWIEAGHPVDPAAYHVATRDGVTTQLGDDVAFSASSGTVACMTDARHTS FT GTLACLVRLANPPPRPETAYGEWKGGWVDFDGIHLQVGSARADPGPFVYGNGPELANGD FT TLSIGDYRCRSYQAGLFCVNYAHQSAVRFASAGIEPFGCLKPAPPPDGVGVAFGC" FT CDS complement(70875..73439) FT /transl_table=11 FT /gene="Mb2073c" FT /locus_tag="Mb2073c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2073c, -, len: 854 aa. Equivalent to Rv2047c, len: FT 854 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 854 aa overlap). Conserved hypothetical FT protein, similar to hypothetical protein from Mycobacterium FT tuberculosis Rv1868|MTCY359.05c (699 aa) and three possible FT pseudogene fragments from Mycobacterium leprae MLCB2052.16 FT (251 aa), MLCB2052.17 (120 aa), MLCB2052.18 (257 aa). FASTA FT scores: gp|Z98604|MLCB2052_7 (257 aa) opt: 1248, E(): 0, FT (78.6% identity in 248 aa overlap); and Z98604|MLCB2052_5 FT (251 aa) opt: 674, E(): 0, (50.0% identity in 250 aa FT overlap); and Z98604|MLCB2052_6 (120 aa) opt: 608 E() : FT 3.6e-30, (84.0% identity in 106 aa overlap); and Rv1868 FT Z83859|MTCY359_5 (699 aa) opt: 521 E(): 3e-24; (33.0% FT identity in 730 aa overlap)." FT /db_xref="GOA:P65685" FT /db_xref="InterPro:IPR008279" FT /db_xref="UniProtKB/Swiss-Prot:P65685" FT /protein_id="CAD96926.1" FT /translation="MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFI FT AADIRDATAVESAMTGADVVAHCAWVRGRNDHINIDGTANVLKAMAETGTGRIVFTSSG FT HQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDA FT QRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAELELL FT HSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPA FT VDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGL FT RAGGVGIAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNS FT GFFGPSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVAD FT VDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRD FT TAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEAPEFHSAVLAE FT LTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAPQPPTPVIPLRAKPVALLAA FT RQLRDREVRRDRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVS FT GLVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIV FT RPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDA FT QGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR" FT CDS complement(73444..85899) FT /transl_table=11 FT /gene="pks12" FT /locus_tag="Mb2074c" FT /product="Probable polyketide synthase pks12" FT /note="Mb2074c, pks12, len: 4151 aa. Equivalent to Rv2048c, FT len: 4151 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 4151 aa overlap). Probable pks12, FT polyketide synthase similar to many polyketide synthases FT e.g. the second and third modules of polyketide synthase FT from S. erythraea (3567 aa), many other Streptomyces FT enzymes and putative Mycobacterium tuberculosis polyketide FT synthases, e.g. Z85982|MTCY06H11.26 (2126 aa), FASTA FT scores: opt: 6668, E(): 0 (61.2% identity in 2058 aa FT overlap); and Q03132|ERY2_SACER ERYTHRONOLIDE SYNTHASE, FT MODULES 3 from S. erythraea (3567 aa), FASTA scores: opt: FT 5309, E(): 0, (40.5% identity in 4141 aa overlap). Contains FT 2x PS00012 Phosphopantetheine attachment site, 2x PS00606 FT Beta-ketoacyl synthases active site, and PS00343 FT Gram-positive cocci surface proteins 'anchor ing' FT hexapeptide." FT /db_xref="GOA:Q7VES2" FT /db_xref="HSSP:1AF8" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7VES2" FT /protein_id="CAD96927.1" FT /translation="MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCR FT FPGGVDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVA FT DFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG FT MLAEEIEGYRLTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGEC FT DLALAGGVTVNATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDA FT RRLGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGT FT GTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHE FT LLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAV FT PVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVF FT EHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIEL FT LDTAPAFAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAEL FT WKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACG FT ADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASH FT SVEVEAIRGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQA FT VRNACEQGYRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSA FT ASAFVAGVAVNWRGTLDGAGYVELPTYAFDKRRFWLSAEGSGADVSGLGLGASEHPLLG FT AVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDE FT LTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEP FT GADLSVWPPAGAVTVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAG FT GVGGFGVHPALLDAVLHAVVIAGDPDELALPFAWQGVSLHATGASAVRARIAPAGPSAV FT SVELADGLGLPVLSVASMVARPVTERQLLAAVSGSGPDRLFEVIWSPASAATSPGPTPA FT YQIFESVAADQDPVAGSYVRSHQALAAVQSWLTDHESGVLVVATRGAMALPREDVADLA FT GAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGS FT RAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRDI FT MITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPM FT PADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEV FT FATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASL FT RLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDG FT VLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGSWAAGTVLITGGTGMAGSAVAR FT HVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIP FT VQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSS FT MAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLDAADLAR FT LGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASAPTR FT RQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQ FT DLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGLPQEIKHTPAV FT RTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDA FT AGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWEALERAGIDPTGLR FT GSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSS FT SLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFAAAADGT FT GFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALA FT NAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQA FT AAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTRRAGV FT SSFGISGTNAHVIIEAVPVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVRGDD FT GLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTV FT FVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENLLNSTE FT FAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGRL FT MQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNAVAAVADQLRADG FT RRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQLAGDDFGSAAYW FT RRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTTMSALRKDRPE FT PATLTNAVAQGFVTGMDLDWRAVVGEAQFVELPTYAFQRRRFWLSGDGVAADAASLGLA FT ASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGFVELAIRAGDE FT VGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRGDVGTGWVLHAEGA FT LRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMWRRGDEVFAE FT VALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGVSLHAAGAS FT AVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGPDRLFEVTW FT SPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVLQSWLTRDG FT AGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLDDSALAAV FT VTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRLELIPDA FT DAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGD FT RVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLADVQPGQRV FT LIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFR FT AATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAF FT DLFEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLM FT PGSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAG FT AQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSK FT VDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAI FT SLGWGLWDQASAMTSGLATVDFKRFARDGIVAMSSADALQLFDTAMIVDEPFMLPAHID FT FAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALAHRLHGLPEDEQHAVLL FT DLVRSHIATVLGSASPEAIDPDRAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYP FT NSAALAGYMRRELLGSSPQDTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALANET FT ETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE" FT CDS complement(86206..86430) FT /transl_table=11 FT /gene="Mb2075c" FT /locus_tag="Mb2075c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2075c, -, len: 74 aa. Equivalent to Rv2049c, len: FT 74 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 74 aa overlap). Hypothetical protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZ34" FT /protein_id="CAD96928.1" FT /translation="MLTRGEVRALPADAVVLSADDAADLSDRVYQVRCAAEDVVTALDE FT GAAATELRDLCDELIRAARAADGWRRAGA" FT CDS 86734..87069 FT /transl_table=11 FT /gene="Mb2076" FT /locus_tag="Mb2076" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2076, -, len: 111 aa. Equivalent to Rv2050, len: FT 111 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 111 aa overlap). Conserved hypothetical FT protein, similar to hypothetical proteins from FT Mycobacterium leprae, MLCB2052.03c (113 aa), and FT Streptomyces coelicolor A3(2), SC6D7.18c (124 aa). FASTA FT scores: Z98604|MLCB2052_3 Mycobacterium leprae cosmid B2052 FT (113 aa) opt: 737, E(): 0, (97.3% identity in 111 aa FT overlap) and (55% identity in 85 aa overlap) with FT emb|CAB61670.1|AL133213 hypothetical protein SC6D7.18c. FT TBparse score is 0.884" FT /db_xref="UniProtKB/TrEMBL:Q7TZ33" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96929.1" FT /translation="MADRVLRGSRLGAVSYETDRNHDLAPRQIARYRTDNGEEFEVPFA FT DDAEIPGTWLCRNGMEGTLIEGDLPEPKKVKPPRTHWDMLLERRSIEELEELLKERLEL FT IRSRRRG" FT CDS complement(87044..89668) FT /transl_table=11 FT /gene="ppm1" FT /locus_tag="Mb2077c" FT /product="Polyprenol-monophosphomannose synthase Ppm1" FT /note="Mb2077c, ppm1, len: 874 aa. Equivalent to Rv2051c, FT len: 874 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 874 aa overlap). ppm1, FT Polyprenol-monophosphomannose synthase. Transfers mannose FT from GDP-Mannose to all endogenous polyprenol-phosphates in FT Mycobacterium tuberculosis, proven experimentally (A. FT Baulard, Institut Pasteur de Lille: see citation below). FT Very similar to polyprenol-phosphate-mannose synthases from FT Mycobacterium smegmatis (594 aa). Two-domain protein FT similar to products of two adjacent ORFs in Mycobacterium FT leprae MLCB2052.01 (644 aa), probable membrane protein and FT MLCB2052.02 (277 aa). First domain (aa 1 - 590) corresponds FT to membrane protein with similarity to P23930|LNT_ECOLI FT apolipoprotein n-acyltransferase (512 aa) while second FT domain (aa 591 - 874) is similar to Schizosaccharomyces FT pombe dolichol monophosphate mannose synthase (236 aa) and FT to Mycobacterium tuberculosis Rv0539. FASTA scores: Z FT 98604|MLCB2052_1 (644 aa) opt: 2725 E(): 0 ; 67.7% identity FT in 601 aa overlap; and Z98604|MLCB2052_2 (277 aa) opt: 1449 FT E(): 0; 78.9% identity in 275 aa overlap; and FT gp|AF0078|AF007873_1 Schizosaccharomyces pombe FT dolichocholmonophosphate mannose synthase (236 aa) opt: 456 FT E(): 7.8e-19; 34.5% identity in 223 aa overlap and FT sp|P23930|LNT_ECOLI APOLIPOPROTEIN N-ACYLTRANSFERASE (512 FT aa) opt: 330 E(): 1.9e-11; 26.9% identity in 539 aa FT overlap; and polyprenol-phosphate-mannose synthases from FT Mycobacterium smegmatis (594 aa). CAC15462.1|AJ294477 FT putative polyprenol-phosphate-mannose synthase 2 (Ppm2): FT (55% identity in 533 aa overlap)." FT /db_xref="GOA:Q7VES1" FT /db_xref="InterPro:IPR003010" FT /db_xref="UniProtKB/TrEMBL:Q7VES1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96930.1" FT /translation="MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNCW FT WAAVVALALLAWVLTHRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLALATTC FT ALFPGIFGLFAVVVRLLPGWPIWFAVGWAAQEWLKSILPFGGFPWGSVAFGQAEGPLLP FT LVQLGGVALLSTGVALVGCGLTAIALEIEKWWRTGGQGDAPPAVVLPAACICLVLFAAI FT VVWPQVRHAGSGSGGEPTVTVAVVQGNVPRLGLDFNAQRRAVLDNHVEETLRLAADVHA FT GLAQQPQFVIWPENSSDIDPFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRPRENPEW FT TNTAIVWNPGTGPADRHDKAIVQPFGEYLPMPWLFRHLSGYADRAGHFVPGNGTGVVRI FT AGVPVGVATCWEVIFDRAPRKSILGGAQLLTVPSNNATFNKTMSEQQLAFAKVRAVEHD FT RYVVVAGTTGISAVIAPDGGELIRTDFFQPAYLDSQVRLKTRLTPATRWGPILQWILVG FT AAAAVVLVAMRQNGWFPRPRRSEPKGENDDSDAPPGRSEASGPPALSESDDELIQPEQG FT GRHSSGFGRHRATSRSYMTTGQPAPPAPGNRPSQRVLVIIPTFNERENLPVIHRRLTQA FT CPAVHVLVVDDSSPDGTGQLADELAQADPGRTHVMHRTAKNGLGAAYLAGFAWGLSREY FT SVLVEMDADGSHAPEQLQRLLDAVDAGADLAIGSRYVAGGTVRNWPWRRLVLSKTANTY FT SRLALGIGIHDITAGYRAYRREALEAIDLDGVDSKGYCFQIDLTWRTVSNGFVVTEVPI FT TFTERELGVSKMSGSNIREALVKVARWGIEGRLSRSDHARARPDIARPGAGGSRVSRAD FT VTE" FT CDS complement(89826..91430) FT /transl_table=11 FT /gene="Mb2078c" FT /locus_tag="Mb2078c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2078c, -, len: 534 aa. Equivalent to Rv2052c, len: FT 534 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 534 aa overlap). Conserved hypothetical FT protein, very similar to hypothetical protein SC6D7.15 (536 FT aa) from Streptomyces coelicolor A3(2). Smith-Waterman FT scores >emb|CAB61667.1| (AL133213) hypothetical protein FT SC6D7.15 [Streptomyces coelicolor A3(2)] Expect = e-113 FT Identities = 247/533 (46%)" FT /db_xref="GOA:Q7TZ32" FT /db_xref="InterPro:IPR013108" FT /db_xref="UniProtKB/TrEMBL:Q7TZ32" FT /protein_id="CAD96931.1" FT /translation="MSQIPVKLLVNGRVYSPTHPEATAMAVRGDVVAWLGSDDVGRDQF FT PDADVQDLDGRFVAPGFVDSHIHLTATGLMLSGLDLRPATSRAQCLRMVADYAADHPGQ FT PLWGHGWDESAWPENAAPSTADLDAVLGDCPAYLARIDSHSALVSSGLRRLVPELAAAT FT GYTAQRPLTGDAHHLARAAARYLLTDVQLADARAVALQAIAAAGVVAVHECAGPEIGGL FT DDWLRLRALEHGVEVIGYWGEAVATPAQARDLVTETGARGLAGDLFVDGALGSRTAWLH FT EPYADAPDCIGTCHLDVDGIEAHVRACTKAEVTAGFHVIGDAAVSAAVAAFERVVADLG FT VVAVARCGHRLEHVEMVTADQAAKLGAWGVIASVQPNFDELWGGGDGMYARRLGAQRGS FT ELNPLALLASQGVPLALGSDAPVTGFDPWASVRAAVNHRTPGSGVSARAAFAAATRGGW FT RAGGVRDGRIGTLVPGAPASYAIWDAGDFDVDAPRDAVQRWSTDPRSRVPALPRLGPTD FT ALPRCRQTVHRGAVIYG" FT CDS complement(91435..91962) FT /transl_table=11 FT /gene="Mb2079c" FT /locus_tag="Mb2079c" FT /product="Probable transmembrane protein" FT /note="Mb2079c, -, len: 175 aa. Equivalent to Rv2053c, len: FT 175 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 175 aa overlap). Probable transmembrane FT protein" FT /db_xref="GOA:Q7VES0" FT /db_xref="InterPro:IPR007313" FT /db_xref="UniProtKB/TrEMBL:Q7VES0" FT /protein_id="CAD96932.1" FT /translation="MSRLLLSYAVVELAVVFALAATIGFGWTLLVLLATFVLGFGLLAP FT LGGWQLGRRLLWLRSGLAEPRSALSDGALVTVASVLVLVPGLVTTTMGLLLLVPPIRAL FT ARPGLTAIAVRGFLRNVPLTADAAANMAGAFGESGTDPDFIDGEVIDVIDVEPLTLQPP FT RVAAEPPSPGSN" FT CDS 92038..92751 FT /transl_table=11 FT /gene="Mb2080" FT /locus_tag="Mb2080" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2080, -, len: 237 aa. Equivalent to Rv2054, len: FT 237 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 237 aa overlap). Conserved hypothetical FT protein, some similarity to various FT carboxymethylenebutenolidases e.g. sp|O67988|CLCD_RHOOP FT CARBOXYMETHYLENEBUTENOLIDASE (DIENELACTONE HYDROLASE) (DLH) FT >gi|2935034|gb|AAC38252.1| (AF003948) dienelactone FT hydrolase [Rhodococcus opacus] Smith-Waterman scores: FT Length = 252, Expect = 4e-08 Identities = 62/217 (28%). FT Also similar to Rv2765." FT /db_xref="GOA:Q7TZ31" FT /db_xref="InterPro:IPR002925" FT /db_xref="UniProtKB/TrEMBL:Q7TZ31" FT /protein_id="CAD96933.1" FT /translation="MTTIEIDAPAGPIDALLGLPPGQGPWPGVVVVHDAVGYVPDNKLI FT SERIARAGYVVLTPNMYARGGRARCITRVFRELLTKRGRALDDILAARDHLLAMPECSG FT RVGIVGFCMGGQFALVLSPRGFGATAPFYGTPLPRHLSETLNGACPIVASFGTRDPLGI FT GAANRLRKVTAAKNIPADIKSYPGAGHSFANKLPGQPLVRIAGFGYNEAATEDAWRRVF FT EFFGQHLRAGSPGEP" FT CDS complement(93000..93266) FT /transl_table=11 FT /gene="rpsR2" FT /locus_tag="Mb2081c" FT /product="Probable ribosomal protein S18 RpsR2" FT /note="Mb2081c, rpsR2, len: 88 aa. Equivalent to Rv2055c, FT len: 88 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 88 aa overlap). Probable rpsR2, FT ribosomal protein S18, similar to others e.g. FT RR18_ODOSI|P49505 chloroplast 30S ribosomal protein S18 (72 FT aa), FASTA scores: opt: 209, E(): 4.7e-09, (51.6% identity FT in 64 aa overlap); etc. Also similar to FT rpsR|Rv0055|MTCY21D4.18 from Mycobacterium tuberculosis FT (50.0% identity in 84 aa overlap)." FT /db_xref="GOA:P66466" FT /db_xref="InterPro:IPR018275" FT /db_xref="UniProtKB/Swiss-Prot:P66466" FT /protein_id="CAD96934.1" FT /translation="MAAKSARKGPTKAKKNLLDSLGVESVDYKDTATLRVFISDRGKIR FT SRGVTGLTVQQQRQVAQAIKNAREMALLPYPGQDRQRRAALCP" FT CDS complement(93267..93572) FT /transl_table=11 FT /gene="rpsN2" FT /locus_tag="Mb2082c" FT /product="Probable ribosomal protein S14 RpsN2" FT /note="Mb2082c, rpsN2, len: 101 aa. Equivalent to Rv2056c, FT len: 101 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 101 aa overlap). Probable rpsN2, FT ribosomal protein S14, similar to others e.g. FT RS14_ECOLI|P02370 30S ribosomal protein S14 from FT Escherichia coli (100 aa), FASTA scores: opt: 290; E(): FT 1.7e- 13; (46.0% identity in 100 aa overlap); etc. Also FT similar to rpsN|Rv0717|MTCY210.36 from Mycobacterium FT tuberculosis, (50.0% identity in 62 aa overlap)." FT /db_xref="GOA:P66406" FT /db_xref="InterPro:IPR018271" FT /db_xref="UniProtKB/Swiss-Prot:P66406" FT /protein_id="CAD96935.1" FT /translation="MAKKSKIVKNQRRAATVARYASRRTALKDIIRSPSSAPEQRSTAQ FT RALARQPRDASPVRLRNRDAIDGRPRGHLRKFGLSRVRVRQLAHDGHLPGVRKASW" FT CDS complement(93574..93738) FT /transl_table=11 FT /gene="rpmG1" FT /locus_tag="Mb2083c" FT /product="Probable ribosomal protein L33" FT /note="Mb2083c, rpmG1, len: 54 aa. Equivalent to Rv2057c, FT len: 54 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 54 aa overlap). Probable rpmG1, FT ribosomal protein L33. FASTA results: RL33_ECOLI P02436 50S FT ribosomal protein L33 (54 aa) opt: 183; E(): 1.6e-09; 51.0% FT identity in 49 aa overlap. Note that previously known as FT rpmG." FT /db_xref="GOA:P0A5W1" FT /db_xref="InterPro:IPR018264" FT /db_xref="UniProtKB/Swiss-Prot:P0A5W1" FT /protein_id="CAD96936.1" FT /translation="MARTDIRPIVKLRSTAGTGYTYTTRKNRRNDPDRLILRKYDPILR FT RHVDFREER" FT CDS complement(93738..93974) FT /transl_table=11 FT /gene="rpmB2" FT /locus_tag="Mb2084c" FT /product="ribosomal protein L28" FT /note="Mb2084c, rpmB2, len: 78 aa. Equivalent to Rv2058c, FT len: 78 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 78 aa overlap). Probable rpmB2, FT ribosomal protein L28, very similar to rL28 of M. FT tuberculosis. FASTA results: RL28_MYCTU Q10879 50S FT ribosomal protein L28. mycobacter (94 aa) opt: 338; E(): FT 9.8e-19; 64.9% identity in 77 aa overlap. Also similar to FT rpmB (Rv0105c) of Mycobacterium tuberculosis." FT /db_xref="GOA:P66149" FT /db_xref="InterPro:IPR001383" FT /db_xref="UniProtKB/Swiss-Prot:P66149" FT /protein_id="CAD96937.1" FT /translation="MSAHCQVTGRKPGFGNTVSHSHRRSRRRWSPNIQQRTYYLPSEGR FT RIRLRVSTKGIKVIDRDGIEAVVARLRRQGQRI" FT CDS 94087..95622 FT /transl_table=11 FT /gene="Mb2085" FT /locus_tag="Mb2085" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2085, -, len: 511 aa. Equivalent to Rv2059, len: FT 511 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 511 aa overlap). Conserved hypothetical FT protein. Some similarity to EWLA protein FT gp|U52850|ERU52850_1 Erysipelothrix rhusiopathiae 36 k (304 FT aa), FASTA score, opt: 287 E(): 6.9e-09; 27.2% identity in FT 228 aa overlap. There appears to be a frameshift in this FT ORF around position 3315980 that causes an overlap with FT next ORF. C-terminal end of protein may be wrong. No error FT can be found to account for this." FT /db_xref="GOA:Q7TZ30" FT /db_xref="InterPro:IPR006127" FT /db_xref="UniProtKB/TrEMBL:Q7TZ30" FT /protein_id="CAD96938.1" FT /translation="MATPVILVTGHEGTAAVTADLLGLLTDHGTATLRSVAPGSVRRAD FT PRPRCHRREQRRRHRASMKSAIHPDHHPRRLPRCPVLRRDQVVLEMIVITMVGRPSGPG FT ERKWDVWGSVARAVTGGHVPVKSILTGAHADPHSYQASPADAAAIVDAELVIYNGGGYD FT PWVDQVLAGHPGVQAVDAYSLLGAVGDDDAPNEHVFYDPNVAKAVAATIADRLADLDPS FT NSGNYRANAAEFSRGADAIAISEHAIATTYPDAAVIATEPVVHYLLAAAGLKNRTPATF FT IAANENGNDPTPADMAAVLDMIAGREVAALLVNPQTPTAATDELQVAARRAGVPITELT FT ETLPSGTDRDQFCAADRPDRRGRSLRADHADRGLSARGHRVGDLLPTALVCHRRSGGRG FT RPRRASARPGNCVRRTDGRGSRPGCPDRRGTPRDVFADHPRRGGRPGRGCPGRRDRDLG FT GLRRGFRRRRHPAVAGAWSPGVGVRGHHLVCDLPDLLVAPAAPLTSRSRFRPL" FT CDS 95192..95593 FT /transl_table=11 FT /gene="Mb2086" FT /locus_tag="Mb2086" FT /product="Possible conserved integral membrane protein" FT /note="Mb2086, -, len: 133 aa. Equivalent to Rv2060, len: FT 133 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.000% identity in 133 aa overlap). Possible conserved FT integral membrane protein smaller than but similar to FT several hypothetical bacterial proteins e.g. FT >emb|CAC29843.1| (AL583918) putative ABC-transporter FT transmembrane protein [Mycobacterium leprae] Length = 286 FT and P44691|YEBI_HAEIN (261 aa). FASTA scores: FT P44691|YEBI_HAEIN HYPOTHETICAL PROTEIN HI0407 (261 aa) opt: FT 218, E(): 4.2e-08; 31.1% identity in 122 aa overlap. Maybe FT frameshift upstream at position 3315980 but no error can be FT found to account for this." FT /db_xref="GOA:Q7VER9" FT /db_xref="InterPro:IPR001626" FT /db_xref="UniProtKB/TrEMBL:Q7VER9" FT /protein_id="CAD96939.1" FT /translation="MLTVVCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFA FT ALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVAAIATSVVFAEVSAVGGILLS FT LAPGVPVSVFVATISFVIYLICWLLRRRR" FT CDS complement(95594..95998) FT /transl_table=11 FT /gene="Mb2087c" FT /locus_tag="Mb2087c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2087c, -, len: 134 aa. Equivalent to Rv2061c, len: FT 134 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 134 aa overlap). Conserved hypothetical FT protein. Similar to conserved hypothetical proteins from FT Mycobacterium leprae (128 aa) and Streptomyces coelicolor FT (153 aa). Smith-Waterman scores: >emb|CAC30396.1| FT (AL583922) [Mycobacterium leprae], Expect = 7e-47, FT Identities = 92/131 (70%); >emb|CAC14932.1| (AL449216) FT [Streptomyces coelicolor], Expect = 6e-19 Identities = FT 48/124 (38%)." FT /db_xref="GOA:Q7TZ29" FT /db_xref="InterPro:IPR011576" FT /db_xref="UniProtKB/TrEMBL:Q7TZ29" FT /protein_id="CAD96940.1" FT /translation="MTPTFSDLAEAQYLLLTTFTKDGRPKPVPIWAALDTDRGDRLLVI FT TEKKSWKVKRIRNTPRVTLATCTLRGRPTSEAVEATAAILDESQTGAVYDAIVKRYGIQ FT GKLFTFVSKLRGGMRNNIGLELKVAESETG" FT CDS complement(96082..99666) FT /transl_table=11 FT /gene="cobN" FT /locus_tag="Mb2088c" FT /product="Probable cobalamin biosynthesis protein CobN" FT /note="Mb2088c, cobN, len: 1194 aa. Equivalent to Rv2062c, FT len: 1194 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1194 aa overlap). Probable cobN, FT cobalamin biosynthesis protein - very similar to COBN_PSEDE FT P29929 cobn protein. Pseudomonas denitrifica (1275 aa), FT FASTA scores, opt: 831, E(): 0, (37.5% identity in 983 aa FT overlap). Also similar to several Mg2+-chelatases e.g. FT H64479 magnesium chelatase subunit homolog (1226 aa )opt: FT 962 E(): 0; (27.3% identity in 846 aa overlap)" FT /db_xref="GOA:Q7VER8" FT /db_xref="InterPro:IPR003672" FT /db_xref="UniProtKB/TrEMBL:Q7VER8" FT /protein_id="CAD96941.1" FT /translation="MPEPTVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDLLAE FT ASIVVIRILGGYRAWQSGIDTVIAGGVPAALVSGEQAADAELTDRSTVAAGTALQAHIY FT LAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWGVLERPDAGKTGPTIAVLYYRAQ FT HLAGNTGYVEALCRAIEDAGGRPLPLYCASLRTAEPRLLERLGGADAMVVTVLAAGGVK FT PAAASAGGDDDSWNVEHLAALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQVAVPEF FT DGRIITVPFSFKEIDDDGLISYVADPERCARVAGLAVRHARLRQVAPADKRVALVFSAY FT PTKHARIGNAVGLDTPASAVALLQAMRQRGYRVGDLPGVESNDGDALIHALIECGGHDP FT DWLTEGQLAGNPIRVSAKEYRDWFATLPAELTDVVTAYWGPPPGELFVDRSHDPDGEIV FT IAALRAGNLVLMVQPPRGFGENPVAIYHDPDLPPSHHYLAAYRWLDTGFSNGFGAHAVV FT HLGKHGNLEWLPGKTLGMSASCGPDAALGDLPLIYPFLVNDPGEGTQAKRRAHAVLVDH FT LIPPMARAETYGDIARLEQLLDEHASVAALDPGKLPAIRQQIWTLIRAAKMDHDLGLTE FT RPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQNPTGEQELDLVLAILRARQLFGGA FT HAIPGLRQALGLAEDGTDERATVDQTEAKARELVAALQATGWDPSAADRLTGNADAAAV FT LRFAATEVIPRLAGTATEIEQVLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPK FT AVPSRLAWEAGVALADSLLARYRDEHGRWPRSVGLSVWGTSAMRTAGDDIAEVLALLGV FT RPVWDDASRRVIDLAPMQPAELGRPRIDVTVRISGFFRDAFPHVVTMLDDAVRLVADLD FT EAAEDNYVRAHAQADLAHHGDQRRATTRIFGSKPGTYGAGLLQLIDSRSWRDDADLAQV FT YTAWGGFAYGRDLDGREAIDDMNRQYRRIAVAAKNTDTREHDIADSDDYFQYHGGMVAT FT VRALTGQAPAAYIGDNTRPDAIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEM FT AATVDYLFGYDATAGVMADWMYEQLTQRYVLDAQNRTFMTESNPWALHGMAERLLEAAG FT RGLWAQPAPETLDGLRQVLLETEGDLEA" FT CDS 99744..99977 FT /transl_table=11 FT /gene="Mb2089" FT /locus_tag="Mb2089" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2089, -, len: 77 aa. Equivalent to Rv2063, len: 77 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 77 aa overlap). Conserved hypothetical protein, FT showing some similarity to other conserved hypothetical FT proteins e.g. AL109974_2|SCF34.02c hypothetical protein FT from Streptomyces coelicolor (133 aa), FASTA scores: opt: FT 102, E(): 1.7, (34.35% identity in 67 aa overlap); and FT AE005182_1 from Escherichia coli strain O157:H7 (77 aa), FT FASTA scores: opt: 95, E(): 3.3, (34.85% identity in 66 aa FT overlap). This ORF replaces previous Rv2063c on other FT strand." FT /db_xref="GOA:Q7TZ28" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/TrEMBL:Q7TZ28" FT /protein_id="CAD96942.1" FT /translation="MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIF FT RAEREASHAETTTQAVRDEDREWEGTVGDGLG" FT CDS 100364..101455 FT /transl_table=11 FT /gene="cobG" FT /locus_tag="Mb2090" FT /product="Possible cobalamin biosynthesis protein CobG" FT /note="Mb2090, cobG, len: 363 aa. Equivalent to Rv2064, FT len: 363 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 363 aa overlap). Possible cobG, FT cobalamin biosynthesis protein. Some similarity to FT COBG_PSEDE P21637 cobg protein. pseudomonas (459 aa) FASTA FT scores, opt: 240, E(): 1.3e-08, (27.5% identity in 407 aa FT overlap); contains PS01156 TonB-dependent receptor proteins FT signature 2" FT /db_xref="GOA:Q7VER7" FT /db_xref="InterPro:IPR012798" FT /db_xref="UniProtKB/TrEMBL:Q7VER7" FT /protein_id="CAD96943.1" FT /translation="MAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLASV FT ASDFGSATLELTARGNVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLSGRAG FT GLADVRAWVGELDAAIRAEPRLAELGGRFWFGLDDGRADVSGLGADVGVQVFPDGPRLL FT LTGRDTGVRVADVAETLIEVALRFVKIRETAWRVTELADIGELQSGVELGPSVRPVTKT FT PVGWIPQDDSRVTLGAAVPLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDATADAA FT LRVLAPLGLVFDENSPWLNISACTGSPGCAHSAADVRADAARSLNVESAGHRHFVGCER FT ACGSPPAGEVLVATGGGYRRLRP" FT CDS 101465..102091 FT /transl_table=11 FT /gene="cobH" FT /locus_tag="Mb2091" FT /product="Probable precorrin-8X methylmutase CobH (aka FT precorrin isomerase)" FT /EC_number="5.4.1.2" FT /note="Mb2091, cobH, len: 208 aa. Equivalent to Rv2065, FT len: 208 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 208 aa overlap). Probable cobH, FT precorrin-8X methylmutase (aka precorrin isomerase) (EC FT 5.4.1.2), similar to COBH_PSEDE P21638 precorrin isomerase FT (210 aa), FASTA scores: opt: 750, E(): 0, (55.4% identity FT in 202 aa overlap)." FT /db_xref="GOA:P63840" FT /db_xref="HSSP:1F2V" FT /db_xref="InterPro:IPR003722" FT /db_xref="UniProtKB/Swiss-Prot:P63840" FT /protein_id="CAD96944.1" FT /translation="MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQ FT VDVAEHVAYTDDVVARAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVADPRAT FT ELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGGPVG FT FVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE" FT CDS 102088..103614 FT /transl_table=11 FT /gene="cobI" FT /locus_tag="Mb2092" FT /product="Probable bifunctional protein, CobI-CobJ fusion FT protein: S-adenosyl-L-methionine-precorrin-2 methyl FT transferase + precorrin-3 methylase" FT /EC_number="2.1.1.-" FT /note="Mb2092, cobI, len: 508 aa. Equivalent to Rv2066, FT len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 508 aa overlap). Probable CobI-CobJ FT fusion protein, S-adenosyl-L-methionine-precorrin-2 methyl FT transferase and precorrin-3 methylase (EC 2.1.1.-). Similar FT in N-terminal half (aa 1-240) to COBI_PSEDE|P21639, FT S-adenosyl-L-methionine-precorrin-2 methyl transferase (244 FT aa), FASTA scores: opt: 759, E(): 4.4e-34, (49.2% identity FT in 238 aa overlap); and in C-terminal half (aa 240-508) to FT P21640|COBJ_PSEDE PRECORRIN-3 METHYLASE (EC 2.1.1.-) (254 FT aa), FASTA scores: opt: 695, E(): 0, (45.3% identity in 258 FT aa overlap)." FT /db_xref="GOA:P66878" FT /db_xref="InterPro:IPR003043" FT /db_xref="UniProtKB/Swiss-Prot:P66878" FT /protein_id="CAD96945.1" FT /translation="MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSI FT ARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVA FT LLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGT FT LPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAAD FT VDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRG FT YLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEA FT EQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADL FT VLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLN FT PAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD" FT CDS complement(103560..104783) FT /transl_table=11 FT /gene="Mb2093c" FT /locus_tag="Mb2093c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2093c, -, len: 407 aa. Equivalent to Rv2067c, len: FT 407 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 407 aa overlap). Conserved hypothetical FT protein, some similarity to YAT1_SYNP6 P08442 atp synthase FT subunits region ORF 1. (417 aa), FASTA scores, opt: 373, FT E(): 4.9e-18, (27.7% identity in 358 aa overlap)" FT /db_xref="InterPro:IPR013217" FT /db_xref="UniProtKB/Swiss-Prot:P0A5G2" FT /protein_id="CAD96946.1" FT /translation="MTDDHPRADIVSRQYHRWLYPHPIADLEAWTTANWEWFDPVHSHR FT ILWPDREYRPDLDILIAGCGTNQAAIFAFTNRAAKVVAIDISRPALDHQQYLKDKHGLA FT NLELHLLPIEELATLGRDFDLVVSTGVLHHLADPRAGMKELAHCLRRDGVVAAMLYGKY FT GRIGVELLGSVFRDLGLGQDDASIKLAKEAISLLPTYHPLRNYLTKARDLLSDSALVDT FT FLHGRQRSYTVEECVDLVTSAGLVFQGWFHKAPYYPHDFFVPNSEFYAAVNTLPEVKAW FT SVMERLETLNATHLFMACRRDRPKEQYTIDFSTVAALDYVPLMRTRCGVSGTDMFWPGW FT RMAPSPAQLAFLQQVDGRRTIREIAGCVARTGEPSGGSLADLEEFGRKLFQSLWRLDFV FT AVALPASG" FT CDS complement(104799..105722) FT /transl_table=11 FT /gene="blaC" FT /locus_tag="Mb2094c" FT /product="CLASS A BETA-LACTAMASE BLAC" FT /EC_number="3.5.2.6" FT /note="Mb2094c, blaC, len: 307 aa. Equivalent to Rv2068c, FT len: 307 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 307 aa overlap). blaC, class A FT beta-lactamase (EC 3.5.2.6) (see citation below), similar FT to e.g. BLAC_NOCLA Q06316 beta-lactamase precursor (302 FT aa), FASTA scores, opt: 860, E(): 0, (50.2% identity in 283 FT aa overlap); eyc. Contains PS00013 Prokaryotic lipid FT attachment site near N-terminus, and PS00146 Beta-lactamase FT class-A active site. BELONGS TO THE CLASS-C BETA-LACTAMASE FT FAMILY." FT /db_xref="GOA:P0A5I7" FT /db_xref="HSSP:1I2S" FT /db_xref="InterPro:IPR000871" FT /db_xref="UniProtKB/Swiss-Prot:P0A5I7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96947.1" FT /translation="MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLA FT DRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLD FT KLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAA FT FTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRAL FT LTDWMARNTTGAKRIRAGFPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDR FT AGGGYDAEPREALLAEAATCVAGVLA" FT CDS 105857..106414 FT /transl_table=11 FT /gene="sigC" FT /locus_tag="Mb2095" FT /product="Probable RNA polymerase sigma factor, ECF FT subfamily, SigC" FT /note="Mb2095, sigC, len: 185 aa. Equivalent to Rv2069, FT len: 185 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 185 aa overlap). Probable sigC, RNA FT polymerase sigma factor (see citation below), with FT similarity to SIGX_BACSU|P35165 probable RNA polymerase FT sigma factor from Bacillus subtilis (194 aa), FASTA scores: FT opt: 218, E(): 4.1e-07, (32.6% identity in 129 aa overlap). FT Belongs to ECF subfamily." FT /db_xref="GOA:P66810" FT /db_xref="HSSP:1OR7" FT /db_xref="InterPro:IPR013249" FT /db_xref="UniProtKB/Swiss-Prot:P66810" FT /protein_id="CAD96948.1" FT /translation="MTATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLS FT DVGSADDLTQETFLRAIGAIPRFSARSSARTWLLAIARHVVADHIRHVRSRPRTTRGAR FT PEHLIDGDRHARGFEDLVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPVGTI FT RSRVARARDALLADAEPDDLTG" FT CDS complement(106404..107099) FT /transl_table=11 FT /gene="cobK" FT /locus_tag="Mb2096c" FT /product="Probable precorrin-6X reductase CobK" FT /EC_number="1.3.1.54" FT /note="Mb2096c, cobK, len: 231 aa. Similar to Rv2070c, len: FT 244 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.7% identity in 227 aa overlap). Probable cobK, FT precorrin-6x reductase (EC 1.3.1.54), similar to e.g. FT L21196|g347169|RERCOBLMK3 RERCOBLMKN from Rhodococcus sp. FT NI86/21 (248 aa), FASTA scores: opt: 792, E(): 0, (53.6% FT identity in 250 aa overlap). Also similarity to FT CBIJ_SALTY|Q05591 cbij protein from Salmonella typhimurium FT (263 aa), FASTA scores: opt: 166, E(): 9e-0 5, (26.7% FT identity in 258 aa overlap). REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium bovis, a single base insertion (*-a) leads FT to a shorter product with a different NH2 part compared to FT its homolog in Mycobacterium tuberculosis strain H37Rv (231 FT aa versus 244 aa)." FT /db_xref="GOA:Q7VER6" FT /db_xref="InterPro:IPR003723" FT /db_xref="UniProtKB/TrEMBL:Q7VER6" FT /protein_id="CAD96949.1" FT /translation="MRWRKSCNPHVEIVSSLAGRVPNPALPIGPVRIGGFGGVEGLRGW FT LREERIDAVVDATHPFAVTITAHAAQVCGELGLPYLVLARPPWDPGTAIIAVSDIEAAD FT VVAEQGYSRVFLTTGRSGIAAFANSDAWFLIRVVTAPDGTALPRRHKLVLSRGPYGYHD FT EFALLREQRIDALVTKNSGGKMTRAKLDAAAALGISVVMIARPLLPAGVAAVDSVHRAA FT MWVAGLPSR" FT CDS complement(107136..107891) FT /transl_table=11 FT /gene="cobM" FT /locus_tag="Mb2097c" FT /product="Probable precorrin-4 C11-methyltransferase CobM" FT /EC_number="2.1.1.133" FT /note="Mb2097c, cobM, len: 251 aa. Equivalent to Rv2071c, FT len: 251 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 251 aa overlap). Probable cobM, FT precorrin-3 methylase (EC 2.1.1.133), similar to e.g. FT L21196|g347169|RERCOBLMK2 RERCOBLMK from Rhodococococcus FT sp. NI86/21 (249 aa), FASTA scores: opt: 992, E(): 0, FT (62.4% identity in 245 aa overlap) and to COBM_ FT PSEDE|P21922 precorrin-3 methylase (253 aa), FASTA scores: FT opt: 863, E(): 0, (54.6% identity in 249 aa overlap). FT Contains PS00839 Uroporphyrin-III C-methyltransferase FT signature 1, and PS00840 Uroporphyrin-III FT C-methyltransferase signature 2." FT /db_xref="GOA:Q7VER5" FT /db_xref="HSSP:1CBF" FT /db_xref="InterPro:IPR014777" FT /db_xref="UniProtKB/TrEMBL:Q7VER5" FT /protein_id="CAD96950.1" FT /translation="MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQC FT PPGATIVDTGPLTLEQIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGY FT EIVPGVPAFAAAAAALKRELTVPGVAQTVTLTRVATLSTPMPPGEDLAALARSRATLVL FT HLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTA FT VIVVGDVLTAEGFTDSYLYSVARHGRYAQ" FT CDS complement(107888..108772) FT /transl_table=11 FT /gene="cobLb" FT /locus_tag="Mb2098c" FT /product="Probable precorrin-6y methyltransferase CobLb FT [SECOND PART]" FT /EC_number="2.1.1.132" FT /note="Mb2098c, cobLb, len: 294 aa. Equivalent to 3' end of FT Rv2072c, len: 390 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.7% identity in 294 aa overlap). Probable FT cobL, methyl transferase (EC 2.1.1.132), similar to FT L21196|g347169|RERCOBLMK1 from Rhodocococcus sp. NI86/21 FT (447 aa), FASTA scores: opt: 892; E(): 0; (50.1% identity FT in 369 aa overlap), and to COBL_PSEDE|P21921 precorrin-6y FT methylase (413 aa), FASTA scores: opt: 830, E(): 0, (40.6% FT identity in 404 aa overlap). REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium bovis, a large 2029 bp deletion FT (H37Rv2.2330073-2332101-*)(RD9) leads to the loss of the FT NH2 part of cobL, the entire Rv2073 and Rv2074, and the FT COOH part of Mb2100c. In addition, while cobL exists as a FT single gene in Mycobacterium tuberculosis strain H37Rv, in FT Mycobacterium bovis a frameshift due to a single base FT insertion (*-t) splits cobL into 2 parts, cobLa and cobLb." FT /db_xref="GOA:Q7VER4" FT /db_xref="InterPro:IPR014008" FT /db_xref="UniProtKB/TrEMBL:Q7VER4" FT /protein_id="CAD96951.1" FT /translation="MPHVSAVTLACARMGWNVYDTEVISLVTAQPHTAVRRGGRAIVLS FT GDRSTPQALAVLLTEHGRGDSKFSVLEQLGGPAERRRDGTARAWACDPPLDVDELNVIA FT VRYLPDERTSWAPDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWC FT RSWPGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFLGGGVTQ FT PGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRFQHYLGEPLGGFTGWR FT PQLPVTQWSVTKR" FT CDS complement(108714..108902) FT /transl_table=11 FT /gene="cobLa" FT /locus_tag="Mb2099c" FT /product="Probable precorrin-6y methyltransferase CobLa FT [FIRST PART]" FT /EC_number="2.1.1.132" FT /note="Mb2099c, cobLa, len: 62 aa. Similar to 5' end of FT Rv2072c, len: 390 aa, from Mycobacterium tuberculosis FT strain H37Rv, (97.727% identity in 44 aa overlap). Probable FT cobL, methyl transferase (EC 2.1.1.132), similar to FT L21196|g347169|RERCOBLMK1 from Rhodocococcus sp. NI86/21 FT (447 aa), FASTA scores: opt: 892; E(): 0; (50.1% identity FT in 369 aa overlap), and to COBL_PSEDE|P21921 precorrin-6y FT methylase (413 aa), FASTA scores: opt: 830, E(): 0, (40.6% FT identity in 404 aa overlap). REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium bovis, a large deletion of 2029 bp FT (H37Rv2.2330073-2332101-*) (RD9) leads to the loss of the FT NH2 part of cobL, the entire Rv2073 and Rv2074, and the FT COOH part of Mb2100c. In addition, while cobL exists as a FT single gene in Mycobacterium tuberculosis strain H37Rv, in FT Mycobacterium bovis a frameshift due to a single base FT insertion (*-t) splits cobL into 2 parts, cobLa and cobLb." FT /db_xref="GOA:Q7VER3" FT /db_xref="UniProtKB/TrEMBL:Q7VER3" FT /protein_id="CAD96952.1" FT /translation="MLPAVQGLSPDGADLHVVASGDPLLHGIGSTLIRLFGHDNVTVFA FT ARVRGDVGVRPDGLERV" FT CDS complement(108977..109765) FT /transl_table=11 FT /gene="Mb2100c" FT /locus_tag="Mb2100c" FT /product="Possible hypothetical exported or envelope FT protein" FT /note="Mb2100c, -, len: 262 aa. Equivalent to 5' end of FT Rv2075c, len: 487 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 259 aa overlap). Possibly FT exported or envelope protein; has potential signal peptide FT at N-terminus and hydrophobic stretch around residue 430. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT large 2029 bp deletion (RD9) leads to the loss of the COOH FT part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 FT part of cobL compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv." FT /db_xref="GOA:Q7VER2" FT /db_xref="InterPro:IPR017946" FT /db_xref="UniProtKB/TrEMBL:Q7VER2" FT /protein_id="CAD96953.1" FT /translation="MPRARWLQSAALMGALAVVLITAAPVAADAYQVPAPPSPTASCDV FT ISPVAIPCVALGKFADAVAAECRRVGVPDARCVLPLAHRVTQAARDAYLQSWVHRTARF FT QDALQDPVPLRETQWLGTHNSFNSLSDSFTVSHADSNQQLSLAQQLDIDVRALELDLHY FT LPRLEGHGAPGVTVCHGLGPKNANLGCTVEPLLATVLPQIANWLNAPGHTEEVILLYLE FT DQLKNASAYESVVATLDQVLRRADGTSLIYRPNPARRGPQ" FT CDS complement(109923..110174) FT /transl_table=11 FT /gene="Mb2101c" FT /locus_tag="Mb2101c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2101c, -, len: 83 aa. Equivalent to Rv2076c, len: FT 83 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 83 aa overlap). Unknown, questionable FT ORF" FT /db_xref="GOA:P64932" FT /db_xref="UniProtKB/Swiss-Prot:P64932" FT /protein_id="CAD96954.1" FT /translation="MVVCLIGGVAGSLWPRPAGRLRGGCYFAFMGVAWVLLAISAIANA FT VKGSLWWDIWSLGLLVLIPAVVYGKMRRSRRISSDQDR" FT CDS complement(110209..111180) FT /transl_table=11 FT /gene="Mb2102c" FT /locus_tag="Mb2102c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb2102c, -, len: 323 aa. Equivalent to Rv2077c, len: FT 323 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 323 aa overlap). Possible conserved FT transmembrane protein. Part of Mycobacterium tuberculosis FT protein family with Rv2542, Rv2079, Rv2797c, Rv0963c, FT Rv1949c. Hydrophobic stretches at C-terminus." FT /db_xref="GOA:P64934" FT /db_xref="UniProtKB/Swiss-Prot:P64934" FT /protein_id="CAD96955.1" FT /translation="MLATLSQIRAWSTEHLIDAAGYWTETADRWEDVFLQMRNQAHAIA FT WNGAGGDGLRQRTRADFSTVSGIADQLRRAATIARNGAGTIDAAQRRVMYAVEDAQDAG FT FNVGEDLSVTDTKTTQPAAVQAARLAQAQALAGDIRLRVGQLVAAENEVSGQLAATTGD FT VGNVRFAGAPVVAHSAVQLVDFFKQDGPTPPPPGAPHPSGGADGPYSDPITSMMLPPAG FT TEAPVSDATKRWVDNMVNELAARPPDDPIAVEARRLAFQALHRPCNSAEWTAAVAGFAG FT SSAGVVGTALAIPAGPADWALLGAALLGVGGSGAAVVNCATK" FT CDS complement(111181..111480) FT /transl_table=11 FT /gene="Mb2103c" FT /locus_tag="Mb2103c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2103c, -, len: 99 aa. Equivalent to Rv2077A, len: FT 99 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 99 aa overlap). Conserved hypothetical FT protein, similar to P95263|Rv1951c CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (137 aa), FASTA FT scores: opt: 271, E(): 1.5e-11, (51.04% identity in 97 aa FT overlap); and some similarity with P95012|Rv2541 FT HYPOTHETICAL ALANINE RICH PROTEIN from Mycobacterium FT tuberculosis (135 aa), FASTA scores: opt: 140, E(): 0.014, FT (32.95% identity in 88 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZ27" FT /protein_id="CAD96956.1" FT /translation="MGSNELQVVLGQLEVAASQSQGLGAQFAASATPPESGQPFQATTV FT AVSGINAAICCAAAEFATRTQATATGVAAAAAAYAHQEATAASEMAAVTQVTVV" FT CDS 111945..112259 FT /transl_table=11 FT /gene="Mb2104" FT /locus_tag="Mb2104" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2104, -, len: 104 aa. Equivalent to Rv2078, len: FT 104 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.0% identity in 104 aa overlap). Unknown" FT /db_xref="UniProtKB/Swiss-Prot:P59982" FT /protein_id="CAD96957.1" FT /translation="MFVDVGLLHSGANESHYAGEHAHGGADQLSRGPLLSGMFGTFPVA FT QTFHDAVGAAHAQQMRNLHAHRQALITVGEKARHAATGFTDMDDGNAAELKAVVCSCAT FT " FT CDS 112241..114211 FT /transl_table=11 FT /gene="Mb2105" FT /locus_tag="Mb2105" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2105, -, len: 656 aa. Equivalent to Rv2079, len: FT 656 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 656 aa overlap). Conserved hypothetical FT protein; part of Mycobacterium tuberculosis protein family FT with Rv2542, Rv2077c, Rv2797c, Rv0963c, Rv1949c. Contains FT PS00120 Lipases, serine active site" FT /db_xref="InterPro:IPR010427" FT /db_xref="UniProtKB/TrEMBL:Q7TZ26" FT /protein_id="CAD96958.1" FT /translation="MQLRHINIRALIAEAGGDPWAIEHSLHAGRPAQIAELAEAFHAAG FT RCTAEANAAFEEARRRFEASWNRENGEHPINDSAEVQRVTAALGVQSLQLPKIGVDLEN FT IAADLAEAQRAAAGRIATLESQLQRIDDQLDQALELEHDPRLAAAERSELDALITCLEQ FT DAIDDTASALGQLQSIRAGYSDHLQQSLAMLRADGYDGAGLQGLDAPQSPVKLEEPIQI FT PPPGTGAPEVHRWWTSLTSEERQRLIAEHPEQIGNLNGVPVSARSDANIAVMTRDLNRV FT RDIATRYRTSVDDVLGDPAKYGLSAGDITRYRNADETKKGLDHNARNDPRNPSPVYLFA FT YDPMAFGGKGRAAIAIGNPDTAKHTAVIVPGTSSSVKGGWLHDNHDDALNLFNQAKAAD FT PNNPTAVIAWMGYDAPNDFTDPRIATPMLARIGGAALAEDVNGLWVTHLGVGQNVTVLG FT HSYGSTTVADAFALGGMHANDAVLLGCPGTDLAHSAASFHLDGGRVYVGAASTDPISML FT GQLDSLSQYVNRGNLAGQLQGLAVGLGTDPAGDGFGSVRFRAEVPNSDGINPHDHSYYY FT HRGSEALRSMADIASGHGDALASDGMLAQPRHQPGVEIDIPGLGSVEIDIPGTPASIDP FT EWSRPPGSITDDHVFDAPLHR" FT CDS 114192..114755 FT /transl_table=11 FT /gene="lppJ" FT /locus_tag="Mb2106" FT /product="Possible lipoprotein LppJ" FT /note="Mb2106, lppJ, len: 187 aa. Equivalent to Rv2080, FT len: 187 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 187 aa overlap). Possible lppJ, FT lipoprotein; contains prokayotic lipoprotein modification FT site (PS00013) and signal sequence at N-terminus." FT /db_xref="GOA:Q7VER1" FT /db_xref="UniProtKB/Swiss-Prot:Q7VER1" FT /protein_id="CAD96959.1" FT /translation="MPHSTADRRLRLTRQALLAAAVAPLLAGCALVMHKPHSAGSSNPW FT DDSAHPLTDDQAMAQVVEPAKQIVAAADLQAVRAGFSFTSCNDQGDPPYQGTVRMAFLL FT QGDHDAYFQHVRAAMLSHGWIDGPPPGQYFHGITLHKNGVTANMSLALDHSYGEMILDG FT ECRNTTDHHHDDETTNITNQLVQP" FT CDS complement(114951..115394) FT /transl_table=11 FT /gene="Mb2107c" FT /locus_tag="Mb2107c" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /note="Mb2107c, -, len: 147 aa. Equivalent to Rv2081c, len: FT 146 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 147 aa overlap). Possible transmembrane FT unknown protein. Hydrophobic stretch from aa 32-54. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 3 FT bp insertion (*-ggg) leads to a slightly longer product FT compared t its homolog in Mycobacterium tuberculosis strain FT H37Rv (147 aa versus 146 aa)." FT /db_xref="GOA:Q7TZ25" FT /db_xref="UniProtKB/TrEMBL:Q7TZ25" FT /protein_id="CAD96960.1" FT /translation="MFANAGLSPFVAIWTARAASLYTSHNFWCAAAVSAAVYVGSAVVP FT AAVAGPLFVGRVSATIKAAAPSTTAAIATLATAANGQLRERGGAGGWVGVHCPVVGGGG FT GVGHPRKAIAAAVSVHSTCMPAAFGGHLGLGDRSRSVSLSGTP" FT CDS 115598..117763 FT /transl_table=11 FT /gene="Mb2108" FT /locus_tag="Mb2108" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2108, -, len: 721 aa. Equivalent to Rv2082, len: FT 721 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 721 aa overlap). Conserved hypothetical FT protein. Similar to Mycobacterium tuberculosis Rv0029, and FT to Rv3899c and Rv3900c which may be frameshifted." FT /db_xref="UniProtKB/TrEMBL:Q7TZ24" FT /protein_id="CAD96961.1" FT /translation="MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEAN FT DLRNERSLLAVNQGRTADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYLRDRL FT TEIAQSGNQQINQILAGKGPIEAKVAAVNAVIEQSNAMADHVGATAMSNIIDATQRVFD FT ETIGGDAHTWLRDHGVSLDAPARPRPVTAEDMTSMTANSPAGSPFGAAPSAPSHSTTTS FT GPPTAPTPTSPFGTAPMVLSSSSTSSGPPTAPTPTSPFGTAPMPPGPPPPGTVSPPLPP FT SAPAVGVGGPSVPAAGMPPAAAAATAPLSPQSLGQSFTTGMTTGTPAAAGAQALSAGAL FT HAATEPLPPPAPPPTTPTVTTPTVATATTAGIPHIPDSAPTPSPAPIAPPTTDNASAMT FT PIAPMVANGPPASPAPPAAAPAGPLPAYGADLRPPVTTPPATPPTPTGPISGAAVTPSS FT PAAGGSLMSPVVNKSTAPATTQAQPSNPTPPLASATAAATTGAAAGDTSRRAAEQQRLR FT RILDTVARQEPGLSWAAGLRDNGQTTLLVTDLASGWIPPHIRLPAHITLLEPAPRRRHA FT TVTDLLGTTTVAAAHHPHGYLSQPDPDTPALTGDRTARIAPTIDELGPTLVETVRRHDT FT LPRIAQAVVVAATRNYGVPDNETDLLHHKTTEIHQAVLTTYPNHDIATVVDWMLLAAIN FT ALIAGDQSGANYHLAWAIAAISTRRSR" FT CDS 117760..118704 FT /transl_table=11 FT /gene="Mb2109" FT /locus_tag="Mb2109" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2109, -, len: 314 aa. Equivalent to Rv2083, len: FT 314 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 314 aa overlap). Conserved hypothetical FT protein. Similar to Mycobacterium tuberculosis Rv3898c (110 FT aa) and Rv3897c (210 aa)" FT /db_xref="UniProtKB/TrEMBL:Q7TZ23" FT /protein_id="CAD96962.1" FT /translation="MTSIESHPEQYWAAAGRPGPVPLALGPVHPGGPTLIDLLMALFGL FT STNADLGGTNADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVGAQGMAQMASGIGG FT ALSGALGGVMGPLTQLPQQAMQAGQGAMQPLMSAMQQAQGADGLAAVDGARLLDSIGGE FT PGLGSGAGGGDVGGGGAGGTTPTGYLGPPPVPTSSPPTTPAGAPTKSATMPPPGGASPA FT SAHMGAAGMPMVPPGAMGARGEGSGQEKPVEKRVTAPAVPNGQPVKGRLTVPPSAPTTK FT PTDGKPVVRRRILLPEHKDFGRIAPDEKTDAGE" FT CDS 118697..119692 FT /transl_table=11 FT /gene="Mb2110" FT /locus_tag="Mb2110" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2110, -, len: 331 aa. Similar to 5' end of Rv2084, FT len: 378 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 284 aa overlap). Hypothetical unknown FT protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv2084 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to an 11 bp FT insertion (*-ggcgtacacac), splits Rv2084 into 2 parts, FT Mb2110 and Mb2111." FT /db_xref="UniProtKB/TrEMBL:Q7TZ22" FT /protein_id="CAD96963.1" FT /translation="MSDDSSSAFDLICAEIERQLRGGELLMDAAAASELLLTVRYQLDT FT QPRPLVIVHGPLFQAVKAARAQVYGRLIQLRHARCEVLDERWQLRPTGQRDVRALLIDV FT LNVLLAAITAAGVERAYACAERRAMAAAVVAKNYRDALGVELQCNSVCRAAAEAIHALA FT HRTGATEDADCLPPVDVIHADVTRRMHGEVATDVVAAGELVIAARHLLDPMPRGELSYG FT PLHEGGNAARKSVYRRLVQLWQARRAVTDGDVDLRDARTLLTDLDSILREMRTAATIQQ FT AYTRAERRAMAAAVVAKIRGDAMGLDAQRDAVHRAAADALHALQSVGIHQ" FT CDS 119512..119844 FT /pseudo FT /transl_table=11 FT /gene="Mb2111" FT /locus_tag="Mb2111" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2111, -, len: 110 aa. Similar to 3' end of Rv2084, FT len: 378 aa, from Mycobacterium tuberculosis strain H37Rv, FT (97.0% identity in 100 aa overlap). Hypothetical unknown FT protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis stain H37Rv, Rv2084 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to an 11 bp FT insertion (*-ggcgtacacac), splits Rv2084 into 2 parts, FT Mb2110 and Mb2111." FT repeat_region 119842..121310 FT /mobile_element="insertion sequence:IS1556" FT /locus_tag="IS1556" FT /note="IS1556, len: 1469 nt. Equivalent to IS1556, len: FT 1469 nt, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 1469 nt overlap). Possible IS-like FT region." FT CDS 119927..120232 FT /transl_table=11 FT /gene="Mb2112" FT /locus_tag="Mb2112" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2112, -, len: 101 aa. Equivalent to Rv2085, len: FT 101 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 101 aa overlap). Conserved hypothetical FT protein, similar to YI32_MYCTU P19772 insertion element FT IS986 hypothetical 6.6 kda protein (59 aa), FASTA scores, FT opt: 119, E(): 0.002 9, (36.4% identity in 55 aa overlap); FT ORFs Rv2085, Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) FT all show similarity to transposases but we can find no FT sequence errors to account for the frameshifts. Contains FT possible helix-turn-helix motif at aa 33 to 54,(+3.11 SD)." FT /db_xref="UniProtKB/Swiss-Prot:P64936" FT /protein_id="CAD96965.1" FT /translation="MSDMCDVVSFVGAAERVLRARFRPSPESGPPVHARRCGWSLGISA FT ETLRRWAGQAEVDSGVVAGVSASRSGSVKTSELEQTIEILKVATSFFARKCDPRHR" FT CDS 120211..120816 FT /transl_table=11 FT /gene="Mb2113" FT /locus_tag="Mb2113" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2113, -, len: 201 aa. Equivalent to Rv2086, len: FT 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 201 aa overlap). Conserved hypothetical FT protein: low similarity to transposases; ORFs Rv2085, FT Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show FT similarity to transposases but we can find no sequence FT errors to account for the frameshifts. Start changed since FT first submission (-16 aa)." FT /db_xref="UniProtKB/Swiss-Prot:P64938" FT /protein_id="CAD96966.1" FT /translation="MRPATPLICAFGDKHKHTYGVTPICRALAVHGVQIASRTYFADRA FT AAPSKRALWDTTITEILAGYYEPDAEGKRPPECLYGSLKMWAHLQRQGFRWPSATVKTI FT MRANGWRGVPLAAHITHHRTRPGRGPGPRPGGSAMAGFSNEPAGSGRLHLRADDVEFRL FT HRVRGRRLRRCDRGLGMLADQRRSVRRTRITPRPSRLT" FT CDS 120894..121124 FT /transl_table=11 FT /gene="Mb2114" FT /locus_tag="Mb2114" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2114, -, len: 76 aa. Equivalent to Rv2087, len: 76 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 76 aa overlap). Conserved hypothetical protein, FT with low similarity to transposases; ORFs Rv2085, Rv2086 FT and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to FT transposases but we can find no sequence errors to account FT for the frameshifts. Start changed since first submission FT (-45 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7TZ21" FT /protein_id="CAD96967.1" FT /translation="MLAGLRPSIGIVGDALDNALCETTTGPHRTECSHGSPFRSGPIRT FT LADLEDIASAWVEHTCHTQQGVRIPGRLQPA" FT CDS 121311..123080 FT /transl_table=11 FT /gene="pknJ" FT /locus_tag="Mb2115" FT /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN FT KINASE J PKNJ (PROTEIN KINASE J) (STPK J)" FT /EC_number="2.7.1.-" FT /note="Mb2115, pknJ, len: 589 aa. Equivalent to Rv2088, FT len: 589 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 589 aa overlap). Probable pknJ, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-) FT (see citation below), similar to other FT serine/threonine-protein kinases e.g. PKWA_THECU|P49695 FT putative serine/threonine-protein kinase (742 aa), FASTA FT scores: opt: 457, E(): 2.7e-15, (26.0% identity in 578 aa FT overlap); etc. Contains PS00108 Serine/Threonine protein FT kinases active-site signature. Contains Hank's kinase FT subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN FT KINASES. Experimental studies show evidence of FT auto-phosphorylation." FT /db_xref="GOA:P65733" FT /db_xref="HSSP:1O6Y" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:P65733" FT /protein_id="CAD96968.1" FT /translation="MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVL FT AAELSRDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDALR FT AATMTTARAVYVIGEVAKALDYAHQQGVIHRDIKPANFLLSRAAGGDERVLLSDFGIAR FT ALGDTGLTSTGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPFAAGAGA FT AVAVVAGHLHQPPPTVSDRVPGLSAAMDAVIATAMAKDPMRRFTSAGEFAHAAAAALYG FT GATDGWVPPSPAPHVISQGAVPGSPWWQHPVGSVTALATPPGHGWPPGLPPLPRRPRRY FT RRGVAAVAAVMVVAAAAVTAVTMTSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRSRL FT PGLLPPLDDVKNFVGIQNLVAHEPMLQPQTPNGSINPAECWPAVGGGVPSAYDLGTVIG FT FYGLTIDEPPTGTAPNQVGQLIVAFRDAATAQRHLADLASIWRRCGGRTVTLFRSEWRR FT PVELSTSVPEVVDGITTMVLTAQGPVLRVREDHAIAAKNNVLVDVDIMTPDTSRGQQAV FT IGITNYILAKIPG" FT CDS complement(123097..124224) FT /transl_table=11 FT /gene="pepE" FT /locus_tag="Mb2116c" FT /product="Probable dipeptidase PepE" FT /EC_number="3.4.13.-" FT /note="Mb2116c, pepE, len: 375 aa. Equivalent to Rv2089c, FT len: 375 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 375 aa overlap). Probable pepE, FT dipeptidase, similar to e.g. PEPQ_LACDL P46545, xaa-pro FT dipeptidase (368 aa), FASTA scores, opt: 617, E(): 5.1 FT e-32, (34.7% identity in 363 aa overlap); contains PS00491 FT Aminopeptidase P and proline dipeptidase signature. Also FT similar to Mycobacterium tuberculosis peptidases Rv2861c, FT Rv0734, Rv2535c." FT /db_xref="GOA:P65811" FT /db_xref="HSSP:1A16" FT /db_xref="InterPro:IPR001131" FT /db_xref="UniProtKB/Swiss-Prot:P65811" FT /protein_id="CAD96969.1" FT /translation="MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSR FT AETFERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRVCDWVDGDDPYGLVSAVL FT GGAPVATAVTDSMPALHMLPLADALGVLPVLATDVLRRLRMVKEETEIDALRKAGAAID FT RVHARVPEFLVPGRTEADVAADIAEAIVAEGHSEVAFVIVGSGPHGADPHHGYSDRELR FT EGDIVVVDIGGTYGPGYHSDSTRTYSIGEPDSDVAQSYSMLQRAQRAAFEAIRPGVTAE FT QVDAAARDVLAEAGLAEYFVHRTGHGIGLCVHEEPYIVAGNDLVLVPGMAFSIEPGIYF FT PGRWGARIEDIVIVTEDGAVSVNNCPHELIVVPVS" FT CDS 124273..125397 FT /transl_table=11 FT /gene="Mb2117" FT /locus_tag="Mb2117" FT /product="5'-3' exonuclease" FT /EC_number="3.1.11.-" FT /note="Mb2117, -, len: 374 aa. Equivalent to Rv2090, len: FT 393 aa, from Mycobacterium tuberculosis strain H37Rv, FT (94.7% identity in 393 aa overlap). Probable 5'-3' FT exonuclease, similar to exonuclease part of DNA polymerase, FT e.g. DPO1_MYCTU Q07700 DNA polymerase I (EC 2.7.7.7) (pol FT i) (904 aa), FASTA scores, opt: 461, E(): 1.2e-17, (38.7% FT identity in 292 aa overlap). BELONGS TO FAMILY A OF DNA FT POLYMERASES. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a 57 bp in-frame deletion leads to a FT shorter product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (374 aa versus 393 aa)." FT /db_xref="GOA:Q7VER0" FT /db_xref="HSSP:1BGX" FT /db_xref="InterPro:IPR020047" FT /db_xref="UniProtKB/TrEMBL:Q7VER0" FT /protein_id="CAD96970.1" FT /translation="MPAPDPMRGDPPHPAPPRLRSPLDPTSGDPLHPAPPRLRSPLDPT FT SGDPLHPAPPRLRSPLVLLDGASMWFRSFFGVPSSITAPDGRPVNAVRGFIDSMAVVII FT QQRPNRLAVCLDLDWRPQFRVDLIPSYKAHRVAEPEPNGQPDVEEVPDELTPQVDMIME FT LLDAFGIAMAGAPGFEADDVLGTLATRERRDPVIVVSGDRDLLQVVADDPVPVRVLYLG FT RGLAKATLFGPAEVAERYGLPAHRAGAAYAELALLRGDPSDGLPGVPGVGEKTAATLLA FT RHGSLDQIMAAADDRKTTMAKGLRTKLLAASAYIKAADRVVRVATDAPVTLSTPTDRLP FT LVAADPERTAELATRFGVESSIARLQKALDTLPG" FT CDS complement(125401..126135) FT /transl_table=11 FT /gene="Mb2118c" FT /locus_tag="Mb2118c" FT /product="Probable membrane protein" FT /note="Mb2118c, -, len: 244 aa. Equivalent to Rv2091c, len: FT 244 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 244 aa overlap). Probable membrane FT protein; contains potential transmembrane region. FT Repetitive ORF." FT /db_xref="GOA:P64940" FT /db_xref="UniProtKB/Swiss-Prot:P64940" FT /protein_id="CAD96971.1" FT /translation="MSGPQGSDPRQPWQPPGQGADHSSDPTVAAGYPWQQQPTQEATWQ FT APAYTPQYQQPADPAYPQQYPQPTPGYAQPEQFGAQPTQLGVPGQYGQYQQPGQYGQPG FT QYGQPGQYAPPGQYPGQYGPYGQSGQGSKRSVAVIGGVIAVMAVLFIGAVLILGFWAPG FT FFVTTKLDVIKAQAGVQQVLTDETTGYGAKNVKDVKCNNGSDPTVKKGATFECTVSIDG FT TSKRVTVTFQDNKGTYEVGRPQ" FT CDS complement(126177..128897) FT /transl_table=11 FT /gene="helY" FT /locus_tag="Mb2119c" FT /product="PROBABLE ATP-DEPENDENT DNA HELICASE HELY" FT /EC_number="3.6.1.-" FT /note="Mb2119c, helY, len: 906 aa. Equivalent to Rv2092c, FT len: 906 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 906 aa overlap). Probable helY, DNA FT helicase (EC 3.6.1.-), with similarity to YJF0_YEAST P47047 FT hypothetical helicase in tdh1-gyp6 intergenic region, (1073 FT aa), FASTA scores, opt: 1004, E(): 0, (29.0% identity in FT 970 aa o verlap); contains PS00017 ATP/GTP-binding site FT motif A, PS00402 Binding-protein-dependent transport FT systems inner membrane comp signature. BELONGS TO THE SKI2 FT SUBFAMILY OF HELICASES." FT /db_xref="GOA:Q7TZ20" FT /db_xref="InterPro:IPR012961" FT /db_xref="UniProtKB/TrEMBL:Q7TZ20" FT /protein_id="CAD96972.1" FT /translation="MTELAELDRFTAELPFSLDDFQQRACSALERGHGVLVCAPTGAGK FT TVVGEFAVHLALAAGSKCFYTTPLKALSNQKHTDLTARYGRDQIGLLTGDLSVNGNAPV FT VVMTTEVLRNMLYADSPALQGLSYVVMDEVHFLADRMRGPVWEEVILQLPDDVRVVSLS FT ATVSNAEEFGGWIQMVRGDTTVVVDEHRPVPLWQHVLVGKRMFDLFDYRIGEAEGQPQV FT NRELLRHIAHRREADRMADWQPRRRGSGRPGFYRPPGRPEVIAKLDAEGLLPAITFVFS FT RAGCDAAVTQCLRSPLRLTSEEERARIAEVIDHRCGDLADSDLAVLGYYEWREGLLRGL FT AAHHAGMLPAFRHTVEELFTAGLVKAVFATETLALGINMPARTVVLERLVKFNGEQHMP FT LTPGEYTQLTGRAGRRGIDVEGHAVVIWHPEIEPSEVAGLASTRTFPLRSSFAPSYNMT FT INLVHRMGPQQAHRLLEQSFAQYQADRSVVGLVRGIERGNRILGEIAAELGGSDAPILE FT YARLRARVSELERAQARASRLQRRQAATDALAALRRGDIITITHGRRGGLAVVLESARD FT RDDPRPLVLTEHRWAGRISSADYSGTTPVGSMTLPKRVEHRQPRVRRDLASALRSAAAG FT LVIPAARRVSEAGGFHDPELESSREQLRRHPVHTSPGLEDQIRQAERYLRIERDNAQLE FT RKVAAATNSLARTFDRFVGLLTEREFIDGPATDPVVTDDGRLLARIYSESDLLVAECLR FT TGAWEGLKPAELAGVVSAVVYETRGGDGQGAPFGADVPTPRLRQALTQTSRLSTTLRAD FT EQAHRITPSREPDDGFVRVIYRWSRTGDLAAALAAADVNGSGSPLLAGDFVRWCRQVLD FT LLDQVRNAAPNPELRATAKRAIGDIRRGVVAVDAG" FT CDS complement(128946..129872) FT /transl_table=11 FT /gene="tatC" FT /locus_tag="Mb2120c" FT /product="Probable Sec-independent protein translocase FT transmembrane protein tatC" FT /note="Mb2120c, tatC, len: 308 aa. Equivalent to Rv2093c, FT len: 308 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 308 aa overlap). Probable tatC, FT transmembrane protein, component of twin-arginine FT translocation protein export system (see citation below for FT more information), equivalent to U00017|U00017_1 from FT Mycobacterium leprae (317 aa), FASTA scores: opt: 1722, FT E(): 0, (84.5% identity in 310 aa overlap). Similarity to FT others e.g. P27857|TATC_ECOLI|MTTB|B3839|Z5360|ECS4768 FT Sec-independent protein translocase protein from E. coli FT strain K12 and O157:H7 (258 aa), FASTA scores: opt: 344, FT E(): 6e-16, (32.5% identity in 265 aa overlap). BELONGS TO FT THE TATC FAMILY." FT /db_xref="GOA:P66896" FT /db_xref="InterPro:IPR019822" FT /db_xref="UniProtKB/Swiss-Prot:P66896" FT /protein_id="CAD96973.1" FT /translation="MRAAGLLKRLNPRNRRSRVNPDATMSLVDHLTELRTRLLISLAAI FT LVTTIFGFVWYSHSIFGLDSLGEWLRHPYCALPQSARADISADGECRLLATAPFDQFML FT RLKVGMAAGIVLACPVWFYQLWAFITPGLYQRERRFAVAFVIPAAVLFVAGAVLAYLVL FT SKALGFLLTVGSDVQVTALSGDRYFGFLLNLLVVFGVSFEFPLLIVMLNLAGLLTYERL FT KSWRRGLIFAMFVFAAIFTPGSDPFSMTALGAALTVLLELAIQIARVHDKRKAKREAAI FT PDDEASVIDPPSPVPAPSVIGSHDDVT" FT CDS complement(129889..130140) FT /transl_table=11 FT /gene="tatA" FT /locus_tag="Mb2121c" FT /product="Probable Sec-independent protein translocase FT membrane-bound protein tatA" FT /note="Mb2121c, tatA, len: 83 aa. Equivalent to Rv2094c, FT len: 83 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 83 aa overlap). Probable tatA, FT membrane-bound protein, component of twin-arginine FT translocation protein export system (see citation below for FT more information), equivalent to U00017_2 from FT Mycobacterium leprae (88 aa), FASTA scores: opt: 392, E(): FT 2e-20, (68.2% identity in 88 aa overlap). Similarity to FT others e.g. P27856|O65938|TATA_ECOLI SEC-INDEPENDENT FT PROTEIN TRANSLOCASE PROTEIN from E. coli strains K12 and FT O157:H7 (261 aa), FASTA scores: opt: 111, E(): 0.25, (28.0 FT % identity in 75 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT TATA/E FAMILY." FT /db_xref="GOA:P66890" FT /db_xref="InterPro:IPR006312" FT /db_xref="UniProtKB/Swiss-Prot:P66890" FT /protein_id="CAD96974.1" FT /translation="MGSLSPWHWAILAVVVIVLFGAKKLPDAARSLGKSLRIFKSEVRE FT LQNENKAEASIETPTPVQSQRVDPSAASGQDSTEARPA" FT CDS complement(130208..131158) FT /transl_table=11 FT /gene="Mb2122c" FT /locus_tag="Mb2122c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2122c, -, len: 316 aa. Equivalent to Rv2095c, len: FT 316 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 316 aa overlap). Conserved hypothetical FT protein. Highly similar to ML1330 P54075|YY35_MYCLE FT HYPOTHETICAL 27.0 KD PROTEIN (247 aa) opt: 1127 E(): 0, FT (78.4% identity in 227 aa overlap). Also similar to FT ORF11(1) of Rhodococcus erythropolis. FASTA score: FT Z82004|REZ820043 REZ82004 NID: g1666179 - Rhodococcus (326 FT aa) opt: 624 E(): 1.1e-30; (56.7% identity in 319 aa FT overlap). Contains possible helix-turn-helix motif at aa FT 25-46, ( +2.92 SD)" FT /db_xref="UniProtKB/TrEMBL:Q7TZ19" FT /protein_id="CAD96975.1" FT /translation="MSALSTRLVRLLNMVPYFQANPRITRAEAAAELGVTAKQLEEDLN FT QLWMCGLPGYSPGDLIDFEFCGDTIEVTFSAGIDRPLKLTSPEATGLLVALRALADIPG FT VVDPQAARSAIAKIAAAAGAVAAVAEQAPTESPAAAAVRAAVRNSRALTIDYYAASHDT FT LTTRIVDPIRVLLIGGHSYLEAWSREAEGVRLFRFDRIVDAAELGEPAVPPESARQAPP FT DTSLFDGDLSLPSATLRVAPSASWMLEYYPIRELRQLPDGSCEVVMTYASEDWMTRLLL FT GFGSDVRVLAPESLAQRVRDAATAALDAYQAAAPP" FT CDS complement(131155..132153) FT /transl_table=11 FT /gene="Mb2123c" FT /locus_tag="Mb2123c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2123c, -, len: 332 aa. Equivalent to Rv2096c, len: FT 332 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 332 aa overlap). Conserved hypothetical FT protein. Highly similar to ML1329, P54076|YY36_MYCLE FT HYPOTHETICAL 35.4 KD PROTEIN B21 (331 aa) opt: 1676 E(): 0; FT (80.2% identity in 329 aa overlap) and to ORF10(1) of FT Rhodococcus erythropolis, Z82004|REZ820042 REZ 82004 NID: FT g1666179 (330 aa) opt: 1232, E(): 0; 59.9% identity in 332 FT aa overlap" FT /db_xref="UniProtKB/Swiss-Prot:P64942" FT /protein_id="CAD96976.1" FT /translation="MATSKVERLVNLVIALLSTRGYITAEKIRSSVAGYSDSPSVEAFS FT RMFERDKNELRDLGIPLEVGRVSALEPTEGYRINRDAYALSPVELTPDEAAAVAVATQL FT WESPELITATQGALLKLRAAGVDVDPLDTGAPVAIASAAAVSGLRGSEDVLGILLSAID FT SGQVVQFSHRSSRAEPYTVRTVEPWGVVTEKGRWYLVGHDRDRDATRVFRLSRIGAQVT FT PIGPAGATTVPAGVDLRSIVAQKVTEVPTGEQATVWVAEGRATALRRAGRSAGPRQLGG FT RDGEVIELEIRSSDRLAREITGYGADAIVLQPGSLRDDVLARLRAQAGALA" FT CDS complement(132162..133520) FT /transl_table=11 FT /gene="Mb2124c" FT /locus_tag="Mb2124c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2124c, -, len: 452 aa. Equivalent to Rv2097c, len: FT 452 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 452 aa overlap). Conserved hypothetical FT protein. Similarity to YTH6_ RHOSO P43484 hypothetical FT protein in thcr 5' region (333 aa), FASTA scores opt: 738, FT E(): 0, (38.5% identity in 330 aa overlap). Also highly FT similar to Mycobacterium leprae protein ML1328, FT P54077|YY37_MYCLE HYPOTHETICAL 38.1 KD PROTEIN (336 aa) FT opt: 1985 E(): 0; (96.4% identity in 307 aa overlap)" FT /db_xref="InterPro:IPR011389" FT /db_xref="UniProtKB/Swiss-Prot:P64944" FT /protein_id="CAD96977.1" FT /translation="MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSN FT VFLRNGARLYLDVGSHPEYATAECDSLVQLVTHDRAGEWVLEDLLVDAEQRLADEGIGG FT DIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKA FT ATYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMSETTTML FT KVGTAALVLEMIESGVAFRDFSLDNPIRAIREVSHDVTGRRPVRLAGGRQASALDIQRE FT YYTRAVEHLQTREPNAQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDR FT YDMELSHPKIAQLDLAYHDIKRGRGIFDLLQRKGLAARVTTDEEIAEAVDQPPQTTRAR FT LRGEFISAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVKRLIASM" FT CDS complement(133572..135047) FT /transl_table=11 FT /gene="PE_PGRS36" FT /locus_tag="Mb2125c" FT /product="conserved hypothetical protein, PE_PGRS family" FT /note="Mb2125c, PE_PGRS36, len: 491 aa. Equivalent to FT Rv2099c (PE21) and Rv2098c (PE_PGRS36), len: 58 aa and 433 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 58 aa overlap and 99.8% identity in 433 aa FT overlap). Rv2098c|PE_PGRS36: Member of Mycobacterium FT tuberculosis PE-family, PGRS sub-family. Frameshifted near FT N-terminus. Rv2099c|PE21: 5'-end of Rv2098c (MTCY49.38c), FT then frameshifts. Sequence has been checked, no errors FT found. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 FT genes. In Mycobacterium bovis, a single base insertion FT (*-c) leads to a single product more similar to PE_PGRS36. FT There is also a 3 bp in-frame deletion (ggc-*)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:P0A689" FT /protein_id="CAD96978.1" FT /translation="MSFVIASPEALLAAATDLAAIRSTIRAANAAAAVPTTGALAPAAD FT EVSAGIAALFGAQAQSYQAVSAQAAAFHDRFVQLLNAGGGSYASAEIANAQQNLLNAVN FT APTQTLLGRPLVGDGADGASGPVGQPGGDGGILWGNGGNGGDSTSPGVAGGAGGSAGLI FT GNGGRGGNGAPGGAGGNGGLGGLLLGNGGAGGVGGTGDNGVGDLGAGGGGGDGGLGGRA FT GLIGHGGAGGNGGDGGHGGSGKAGGSGGSGGFGQFGGAGGLLYGNGGAAGSGGNGGDAG FT TGVSSDGFAGLGGSGGRGGDAGLIGVGGGGGNGGDPGLGARLFQVGSRGGDGGVGGWLY FT GDGGGGGDGGNGGLPFIGSTNAGNGGSARLIGNGGAGGSGGSGAPGSVSSGGVGGAGNP FT GGSGGNGGVWYGNGGAGGAAGQGGPGMNTTSPGGPGGVGGHGGTAILFGDGGAGGAGAA FT GGPGTPDGAAGPGGSGGTGGLLFGVPGPSGPDG" FT CDS 135230..136882 FT /transl_table=11 FT /gene="Mb2126" FT /locus_tag="Mb2126" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2126, -, len: 550 aa. Equivalent to Rv2100, len: FT 550 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 550 aa overlap). Conserved hypothetical FT protein. Member of Mycobacterium tuberculosis 13E12 repeat FT family with Rv1148c, Rv1945, Rv3467, Rv0094c, Rv1128c, FT Rv1587c, Rv1702c, Rv3466, Rv1588c." FT /db_xref="GOA:P64946" FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/Swiss-Prot:P64946" FT /protein_id="CAD96979.1" FT /translation="MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLP FT DPTELCRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTGADQRADWACDFWDCA FT AAEVAAALTISHGKASGQMHLSLALNRLPQVAALFLAGHLGARLFSIIAWRTYLVRDPH FT ALSLLDAALAEHAGAWGPLSAPKLEKAIDSWIDRYDPGALRRSRISARTRDLCIGDPDE FT DAGTAALWGRLYATDAAMLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGADHLACG FT CGKPDCPSGAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEALT FT PDPEPDPPATHAPAELITTGGGVVPAPLLAELIRGGATISQVRHPGDLAAEPHYRPSAK FT LAEFVRMRDLTCRFPGCDVPAEFCDIDHSAPWPLGPTHPSNLKCACRKHHLLKTFWTGW FT RDVQLPDGTVIWTAPNGHTYTTHPGSRIFFPTWHTTTAELPQTSTAAVNVDARGLMMPR FT RRRTRAAELAHRINAERALNDAYMAERNKPPSF" FT CDS 137081..140122 FT /transl_table=11 FT /gene="helZ" FT /locus_tag="Mb2127" FT /product="PROBABLE HELICASE HELZ" FT /EC_number="3.6.-.-" FT /note="Mb2127, helZ, len: 1013 aa. Equivalent to Rv2101, FT len: 1013 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 1013 aa overlap). Probable helZ, FT helicase (EC 3.6.-.-), similar to many e.g. FT PCC6803|P74552|SLL1366 HELICASE OF THE SNF2/RAD54 FAMILY FT from Synechocystis sp. strain PCC 6803 (1039 aa), FASTA FT scores: opt: 2015, E(): 0, (38.4% identity in 1063 aa FT overlap); etc." FT /db_xref="GOA:Q7TZ18" FT /db_xref="InterPro:IPR000330" FT /db_xref="UniProtKB/TrEMBL:Q7TZ18" FT /protein_id="CAD96980.1" FT /translation="MLVLHGFWSNSGGMRLWAEDSDLLVKSPSQALRSARPHPFAAPAD FT LIAGIHPGKPATAVLLLPSLRSAPLDSPELIRLAPRPAARTDPMLLAWTVPVVDLDPTA FT ALAAFDQPAPDVRYGASVDYLAELAVFARELVERGRVLPQLRRDTHGAAACWRPVLQGR FT DVVAMTSLVSAMPPVCRAEVGGHDPHELATSALDAMVDAAVRAALSPMDLLPPRRGRSK FT RHRAVEAWLTALTCPDGRFDAEPDELDALAEALRPWDDVGIGTVGPARATFRLSEVETE FT NEETPAGSLWRLEFLLQSTQDPSLLVPAEQAWNDDGSLRRWLDRPQELLLTELGRASRI FT FPELVPALRTACPSGLELDADGAYRFLSGTAAVLDEAGFGVLLPSWWDRRRKLGLVLSA FT YTPVDGVVGKASKFGREQLVEFRWELAVGDDPLSEEEIAALTETKSPLIRLRGQWVALD FT TEQLRRGLEFLERKPTGRKTTAEILALAASHPDDVDTPLEVTAVRADGWLGDLLAGAAA FT ASLQPLDPPDGFTATLRPYQQRGLAWLAFLSSLGLGSCLADDMGLGKTVQLLALETLES FT VQRHQDRGVGPTLLLCPMSLVGNWQQEAARFAPNLRVYAHHGGARLHGEALRDHLERTD FT LVVSTYTTATRDIDELSEYEWNRVVLDEAQAVKNSLSRAAKAVRRLRAAHRVALTGTPM FT ENRLAELWSIMDFLNPGLLGSSERFRTRYAIPIERHGHTEPAERLRASTRPYILRRLKT FT DPAIIDDLPEKIEIKQYCQLTTEQASLYQAVVADMMEKIENTEGIERRGNVLAAMAKLK FT QVCNHPAQLLHDRSPVGRRSGKVIRLEEILEEILAEGDRVLCFTQFTEFAELLVPHLAA FT RFGRAARDIAYLHGGTPRKRRDEMVARFQSGDGPPIFLLSLKAGGTGLNLTAANHVVHL FT DRWWNPAVENQATDRAFRIGQRRTVQVRKFICTGTLEEKIDEMIEEKKALADLVVTDGE FT GWLTELSTRDLREVFALSEGAVGE" FT CDS 140232..140948 FT /transl_table=11 FT /gene="Mb2128" FT /locus_tag="Mb2128" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2128, -, len: 238 aa. Equivalent to Rv2102, len: FT 238 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.000% identity in 238 aa overlap). Conserved FT hypothetical protein, similar to part of hypothetical FT protein D90916_18 (289 aa) from Synechocystis sp. PCC6803. FT Contains PS00017 ATP/GTP-binding site motif A(P-loop). FT FASTA scores: D90916|D90916_18 Synechocystis sp.PCC6803 FT complete (289 aa) opt: 498, E(): 1.9e-25; 46.7% identity in FT 167 aa overlap." FT /db_xref="GOA:Q7TZ17" FT /db_xref="InterPro:IPR007527" FT /db_xref="UniProtKB/TrEMBL:Q7TZ17" FT /protein_id="CAD96981.1" FT /translation="MLEDIGLGNRLQRGRSYARKGQVISLQVDAGLVTALVQGSRARPY FT RIRIGIPAFGKSQWAHVERTLAENAWYAAKLLSGEMPEDIEDVFAGLGLSLFPGTAREL FT SLDCSCPDYAVPCKHLAATFYLLAESFDEDPFAILAWRGREREDLLANLAAARADGAAP FT AADHAEQVAQPLTDCLDRYYARQADINVPSPPATPSTALLDQLPDTGLSARGRPLTELL FT RPAYHALTHHHNSAGG" FT CDS complement(140927..141361) FT /transl_table=11 FT /gene="Mb2129c" FT /locus_tag="Mb2129c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2129c, -, len: 144 aa. Equivalent to Rv2103c, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 144 aa overlap). Conserved hypothetical FT protein, similar to hypothetical mycobacterial proteins FT belonging to family, includes Rv0749, Rv0277c, Rv2530c, FT Rv3320c, Rv2494, Rv2872, Rv0617, Rv1242 etc. FASTA scores: FT sptr|Q49793|Q49793 B2126_C3_261 (97 aa) opt: 331, E(): FT 4.8e-18; 59.4% identity in 96 aa overlap and FT gp|Z74024|MTCY274_3 Mycobacterium tuberculosis cosmid (147 FT aa) opt: 234, E(): 1.2e-10; 34.8% identity in 141 aa FT overlap." FT /db_xref="InterPro:IPR006226" FT /db_xref="UniProtKB/TrEMBL:Q7TZ16" FT /protein_id="CAD96982.1" FT /translation="MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLL FT AFVRLATKVGLFPRPLPREAAITQVADWLAAPSAVLVNPTVRHADILARMLTYVGTGAN FT LVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL" FT CDS complement(141368..141622) FT /transl_table=11 FT /gene="Mb2130c" FT /locus_tag="Mb2130c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2130c, -, len: 84 aa. Equivalent to Rv2104c, len: FT 84 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 84 aa overlap). Conserved hypothetical FT protein, similar to members of a family of hypothetical FT mycobacterial proteins including Rv2871, Rv1241, Rv2132, FT Rv3321c, Rv1113, Rv0657, Rv1560, etc. FASTA scores: FT sptr|Q49787|Q49787 B2126_C2_217 (97 aa) opt: 197, E(): FT 2e-07; 57.1% identity in 56 aa overlap and FT Z95388|MTCY270_36 Mycobacterium tuberculosis cosmid (76 aa FT ) opt: 142, E(): 0.0011; 41.8% identity in 55 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q7TZ15" FT /protein_id="CAD96983.1" FT /translation="MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPS FT HFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQRRGS" FT CDS 142842..143138 FT /transl_table=11 FT /gene="PE22" FT /locus_tag="Mb2131" FT /product="conserved hypothetical protein, PE" FT /note="Mb2131, PE22, len: 98 aa. Equivalent to Rv2107, len: FT 98 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 98 aa overlap). Member of mycobacterial FT PE family e.g. Y03A_MYCTU Q10637 hypothetical glycine-rich FT 49.6 kd protein (603 aa), FASTA scores; opt: 214 E(): FT 1.3e-14, 39.8% identity in 93 aa overlap" FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7VEQ9" FT /protein_id="CAD96984.1" FT /translation="MSFVNVDPFGMLAAAATLESLGSHMAVSNAAVASVTTKVPPPAAD FT YVSKKLSLFFSSHGQQYQVQAARGTAFHRKLVRTLANGALAYEEVEIANNEGF" FT CDS 143194..143925 FT /transl_table=11 FT /gene="PPE36" FT /locus_tag="Mb2132" FT /product="conserved hypothetical protein, PPE" FT /note="Mb2132, PPE36, len: 243 aa. Equivalent to Rv2108, FT len: 243 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 243 aa overlap). N-terminus is similar FT to N-terminal region of Mycobacterium tuberculosis PPE FT family proteins eg. YX23_MYCTU Q10813 hypothetical 41.1 kd FT protein cy274.23 (404 aa), FASTA scores; opt: 431, E(): FT 3.9e-32, 44.0% identity in 166 aa overlap" FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7VEQ8" FT /protein_id="CAD96985.1" FT /translation="MPNFWALPPEINSTRIYLGPGSGPILAAAQGWNALASELEKTKVG FT LQSALDTLLESYRGQSSQALIQQTLPYVQWLTTTAEHAHKTAIQLTAAANAYEQARAAM FT VPPAMVRANRVQTTVLKAINWFGQFSTRIADKEADYEQMWFQDALVMENYWEAVQEAIQ FT STSHFEDPPEMADDYDEAWMLNTVFDYHNENAKEEVIHLVPDVNKERGPIELVTKVDKE FT GTIRLVYDGEPTFSYKEHPKF" FT CDS complement(144465..145211) FT /transl_table=11 FT /gene="prcA" FT /locus_tag="Mb2133c" FT /product="proteasome (alpha subunit) PrcA" FT /EC_number="3.4.25.1" FT /note="Mb2133c, prcA, len: 248 aa. Equivalent to Rv2109c, FT len: 248 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 248 aa overlap). prcA, proteasome FT alpha-type subunit 1, highly similar to TR:Q53080 FT (EMBL:U26421 ) proteasome alpha-type subunit 1 from FT Rhodococcus (259 aa), FASTA scores; opt: 1035, E(): 0, FT 67.2% identity in 247 aa overlap." FT /db_xref="GOA:Q7TZ14" FT /db_xref="InterPro:IPR001353" FT /db_xref="UniProtKB/TrEMBL:Q7TZ14" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96986.1" FT /translation="MSFPYFISPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAEN FT PSRSLQKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYA FT QTLGTIFTEQAKPYEVELCVAEVAHYGETKPPELYRITYDGSIADEPHFVVMGGTTEPI FT ANALKESYAENASLTDALGIAVAALRAGSADTSGGDQPTLGVASLEVAVLDANRPRRAF FT RRITGSALQALLVDQESPQSDGESSG" FT CDS complement(145208..146083) FT /transl_table=11 FT /gene="prcB" FT /locus_tag="Mb2134c" FT /product="proteasome (beta subunit) PrcB" FT /EC_number="3.4.25.1" FT /note="Mb2134c, prcB, len: 291 aa. Equivalent to Rv2110c, FT len: 291 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 291 aa overlap). prcB, proteasome FT beta-type subunit 2, highly similar to eg. TR:Q53083 FT (EMBL:U264 22) proteasome beta-type subunit 2 from FT Rhodococcus (292 aa), FASTA scores; opt: 1103, E(): 0, FT 64.5% identity in 262 aa overlap." FT /db_xref="GOA:Q7TZ13" FT /db_xref="HSSP:1J2Q" FT /db_xref="InterPro:IPR001353" FT /db_xref="UniProtKB/TrEMBL:Q7TZ13" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96987.1" FT /translation="MTWPLPDRLSINSLSGTPAVDLSSFTDFLRRQAPELLPASISGGA FT PLAGGDAQLPHGTTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAG FT TAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAG FT YDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLR FT VAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGA FT DTFGSDGGEK" FT CDS complement(146080..146274) FT /transl_table=11 FT /gene="Mb2135c" FT /locus_tag="Mb2135c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2135c, -, len: 64 aa. Equivalent to Rv2111c, len: FT 64 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 64 aa overlap). Conserved hypothetical FT protein. Highly similar to a hypothetical protein TR:Q53078 FT (EMBL:U26422) (64 aa) upstream of Rhodococcus proteasome FT beta-type subunit 1, FASTA scores; opt: 349, E(): 7.3e-25, FT 84.4% identity in 64 aa overlap" FT /db_xref="InterPro:IPR008515" FT /db_xref="UniProtKB/TrEMBL:Q7TZ12" FT /protein_id="CAD96988.1" FT /translation="MAQEQTKRGGGGGDDDDIAGSTAAGQERREKLTEETDDLLDEIDD FT VLEENAEDFVRAYVQKGGQ" FT CDS complement(146387..147994) FT /transl_table=11 FT /gene="Mb2136c" FT /locus_tag="Mb2136c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2136c, -, len: 535 aa. Similar to Rv2112c, len: FT 554 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 532 aa overlap). Conserved hypothetical FT protein. Highly similar to a hypothetical protein TR:Q53081 FT (EMBL:U26422) (499 aa) upstream of Rhodococcus proteasome FT beta-type subunit 1, FASTA scores opt: 2832 E(): 0, 85.3% FT identity in 502 aa overlap. Also some similarity to FT Mycobacterium tuberculosis hypothetical protein Rv2097c FT (MTCY49.37c, 38.2% identity in 419 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 57 FT bp in-frame deletion at the NH2 part, leads to a shorter FT product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (535 aa versus 554 aa)." FT /db_xref="InterPro:IPR004989" FT /db_xref="UniProtKB/TrEMBL:Q7TZ11" FT /protein_id="CAD96989.1" FT /translation="MFWVGGRCLMPASSAARCAARIVGGPRLYGMQRIIGTEVEYGISS FT PSDPTANPILTSTQAVLAYAAAAGIQRAKRTRWDYEVESPLRDARGFDLSRSAGPPPVV FT DADEVGAANMILTNGARLYVDHAHPEYSAPECTDPLDAVIWDKAGERVMEAAARHVASV FT PGAAKLQLYKNNVDGKGASYGSHENYLMSRQTPFSAIITGLTPFLVSRQVVTGSGRVGI FT GPSGDEPGFQLSQRSDYIEVEVGLETTLKRGIINTRDEPHADADRYRRLHVIIGDANLA FT ETSTYLKLGTTALVLDLIEEGPAHAIDLTDLALARPVHAVHAISRDPSLRATVALADGR FT ELTGLALQRIYLDRVAKLVDSRDPDPRAADIVETWAHVLDQLERDPMDCAELLDWPAKL FT RLLDGFRQRENLSWSAPRLHLVDLQYSDVRLDKGLYNRLVARGSMKRLVTEHQVLSAVE FT NPPTDTRAYFRGECLRRFGADIAAASWDSVIFDLGGDSLVRIPTLEPLRGSKAHVGALL FT DSVDSAVELVEQLTAEPR" FT CDS 148055..149248 FT /transl_table=11 FT /gene="Mb2137" FT /locus_tag="Mb2137" FT /product="Probable integral membrane protein" FT /note="Mb2137, -, len: 397 aa. Equivalent to Rv2113, len: FT 397 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 397 aa overlap). Probable integral FT membrane protein." FT /db_xref="UniProtKB/TrEMBL:Q7VEQ7" FT /protein_id="CAD96990.1" FT /translation="MSLSVRRPPAARAAAIVEAESWFLKRGLPSVLTMRGRCRRLWPRS FT APMLAAWAVVEGCLMAVFFVTDGGEVFISATPTTAQWVILALLAVALPLASLVGWLVSQ FT ISSGRGQAAVATMAVAFAAASDVIESGPIQLLRTAVVVGLVLLQTGCGVGSVLGWAVRM FT TLEHLATVGTLAVRALPIVLLTALVFFNTYVWLMAANINGERLPLAMVFLLAIAGAFVV FT SKTVERVRPLLRSTTVMPQGSQSLAGTPFATMGDPSPGFPLTRAERLNVVFLLAALQLV FT EILVVASVGAAIYLVLGMIILTPPLLREWTHYDSMTTTVLGMTFPAPDSLIRMCLFLGA FT LTFMYISARAVDDAEYRAMFLDPLIDDLHTALLARNRYRNNVVTAPCAGVDAGHVDD" FT CDS 149259..149882 FT /transl_table=11 FT /gene="Mb2138" FT /locus_tag="Mb2138" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2138, -, len: 207 aa. Equivalent to Rv2114, len: FT 207 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 207 aa overlap). Unknown" FT /db_xref="InterPro:IPR016792" FT /db_xref="UniProtKB/TrEMBL:Q7TZ10" FT /protein_id="CAD96991.1" FT /translation="MSAPERVTGLSGQRYGEVLLVTPGEAGPQATVYNSFPLNDCPAEL FT WSALDPQALATEHKAATALLNGPRYWLMNAIEKAPQGPPVTKTFGGIEMLQQATVLLSS FT MNPAPYTVSQVSRNTVFVFNAGEEVYELQDPKGQRWVMQTWSQVVDPNLSRADLPKLGE FT RLNLPAGWSYHTRVLTSELRVDTTNREARVLQDDLTNSYSLVTA" FT CDS complement(149886..151715) FT /transl_table=11 FT /gene="Mb2139c" FT /locus_tag="Mb2139c" FT /product="Probable ATPase" FT /EC_number="3.6.1.-" FT /note="Mb2139c, -, len: 609 aa. Equivalent to Rv2115c, len: FT 609 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 609 aa overlap). Probable ATPase (EC FT 3.6.1.-), similar to e.g. YB56_METJA Q58556 cell division FT cycle protein 48 homolog (903 aa), FASTA scores; opt: 423, FT E(): 8.1e-32, 45.8% identity in 249 aa overlap. Contains FT PS00674 AAA-protein family signature and PS00017 FT ATP/GTP-binding site motif A (P-loop). Also some similarity FT to other Mycobacterium tuberculosis ATPases eg. Rv0435c and FT Rv3610c. Equivalent to Mycobacterium leprae U00 FT 017|U00017_18 (609 aa), FASTA scores; opt: 3670 E(): 0; FT 92.9% identity in 609 aa overlap." FT /db_xref="GOA:P63346" FT /db_xref="HSSP:1IY2" FT /db_xref="InterPro:IPR003960" FT /db_xref="UniProtKB/Swiss-Prot:P63346" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96992.1" FT /translation="MGESERSEAFGIPRDSPLSSGDAAELEQLRREAAVLREQLENAVG FT SHAPTRSARDIHQLEARIDSLAARNSKLMETLKEARQQLLALREEVDRLGQPPSGYGVL FT LATHDDDTVDVFTSGRKMRLTCSPNIDAASLKKGQTVRLNEALTVVEAGTFEAVGEIST FT LREILADGHRALVVGHADEERVVWLADPLIAEDLPDGLPEALNDDTRPRKLRPGDSLLV FT DTKAGYAFERIPKAEVEDLVLEEVPDVSYADIGGLSRQIEQIRDAVELPFLHKELYREY FT SLRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAEVRGDDAHEAKSYFLNIKGPELLNK FT FVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGTGVSSDVETTVVPQLLSE FT IDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAQDIYSKYLTEFLP FT VHADDLAEFDGDRSACIKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVMYFKDFNSGA FT MIQNVVDRAKKNAIKSVLETGQPGLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGK FT KGERIVYIRTLVTGKSSSASRAIDTESNLGQYL" FT CDS 151996..152565 FT /transl_table=11 FT /gene="lppK" FT /locus_tag="Mb2140" FT /product="Probable conserved lipoprotein lppK" FT /note="Mb2140, lppK, len: 189 aa. Equivalent to Rv2116, FT len: 189 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 189 aa overlap). Probable lppK, FT conserved lipoprotein, similar to Mycobacterium leprae FT B2126_F3_115 TR:Q49803 (194 aa), FASTA scores; opt: 624, FT E(): 3.1e-31, 51.6% identity in 190 aa overlap. Contains FT N-terminal signal sequence and PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. Some similarity to FT Rv2376c." FT /db_xref="GOA:P65301" FT /db_xref="InterPro:IPR020235" FT /db_xref="UniProtKB/Swiss-Prot:P65301" FT /protein_id="CAD96993.1" FT /translation="MRRNIRVTLGAATIVAALGLSGCSHPEFKRSSPPAPSLPPVTSSP FT LEAAPITPLPAPEALIDVLSRLADPAVPGTNKVQLIEGATPENAAALDRFTTALRDGSY FT LPMTFAANDIAWSDNKPSDVMATVVVTTAHPDNREFTFPMEFVSFKGGWQLSRQTAEML FT LAMGNSPDSTPSATSPAPAPSPTPPG" FT CDS 152573..152866 FT /transl_table=11 FT /gene="Mb2141" FT /locus_tag="Mb2141" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2141, -, len: 97 aa. Equivalent to Rv2117, len: 97 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 97 aa overlap). Conserved hypothetical protein. FT Similar to hypothetical proteins from Mycobacterium leprae FT TR:Q49798 U2126J (97 aa), FASTA scores; opt: 554, E(): 0, FT 85.6% identity in 97 aa overlap, and Bacillus subtilis FT YLXP_BACSU P32730 hypothetical 10.7 kd protein (92 aa), FT FASTA scores; opt: 173, E(): 1.4e-11, 34.1% identity in 82 FT aa overlap" FT /db_xref="InterPro:IPR007546" FT /db_xref="UniProtKB/TrEMBL:Q7TZ09" FT /protein_id="CAD96994.1" FT /translation="MWIGWLEFDVLLGDVRSLKQKRSVTRPLVAELQRKFSVSAAETGS FT HDLYRRAGIGVAVVSGDRSHAVDVLDNAERLVAAHPEFELLSVRRGLHRTDD" FT CDS complement(152895..153737) FT /transl_table=11 FT /gene="Mb2142c" FT /locus_tag="Mb2142c" FT /product="POSSIBLE RNA METHYLTRANSFERASE" FT /EC_number="2.1.1.-" FT /note="Mb2142c, -, len: 280 aa. Equivalent to Rv2118c, len: FT 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 280 aa overlap). Possible FT S-adenosyl-l-methionine-dependent RNA methyltransferase (EC FT 2.1.1.-) (see citation below); corresponds to Mycobacterium FT leprae B2126_C1_165, similar to hypothetical proteins from FT several organisms e.g. Y134_METJA Q57598 hypothetical FT protein mj0134 (282 aa), FASTA scores; opt: 256, E(): FT 1e-13, FASTA scores; 30.2% identity in 285 aa overlap. The FT larger catalytic C-terminal domain binds the cofactor FT S-adenosyl-l-methionine (AdoMet) and is involved in the FT transfer of methyl group from AdoMet to the substrate." FT /db_xref="GOA:Q7TZ08" FT /db_xref="HSSP:1I9G" FT /db_xref="InterPro:IPR014816" FT /db_xref="UniProtKB/TrEMBL:Q7TZ08" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96995.1" FT /translation="MSATGPFSIGERVQLTDAKGRRYTMSLTPGAEFHTHRGSIAHDAV FT IGLEQGSVVKSSNGALFLVLRPLLVDYVMSMPRGPQVIYPKDAAQIVHEGDIFPGARVL FT EAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNVSGCYGQPPDNWRLVVSDLA FT DSELPDGSVDRAVLDMLAPWEVLDAVSRLLVAGGVLMVYVATVTQLSRIVEALRAKQCW FT TEPRAWETLQRGWNVVGLAVRPQHSMRGHTAFLVATRRLAPGAVAPAPLGRKREGRDG" FT CDS 153811..154647 FT /transl_table=11 FT /gene="Mb2143" FT /locus_tag="Mb2143" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2143, -, len: 278 aa. Equivalent to Rv2119, len: FT 278 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 278 aa overlap). Conserved hypothetical FT protein. Similar to Mycobacterium leprae hypothetical FT protein TR:Q49799 U2126V (212 aa), FASTA scores; opt: 1153, FT E(): 0, 83.6% identity in 195 aa overlap. Orthologs present FT in Rhodococcus erythropolis (gb|AAC68687.1|(AF088800) and FT Streptomyces emb|CAB59506.1|(AL132648)" FT /db_xref="UniProtKB/TrEMBL:Q7TZ07" FT /protein_id="CAD96996.1" FT /translation="MADQPDPPTPRPALSPSRATDFKQCPLLYRFRAIDRLPEATSAAQ FT LRGSVVHAALEQLYGLPAGLRSPDTARSLVQRAWDQMVAAEPELAGELDPGQPTQLLED FT ARALVSGYYRLEDPTRFDPQCCEQRVEVELADGTLLRGYIDRIDVAATGELRVVDYKTG FT KAPPAARALAEFKAMFQMKFYAVALFRSRGVPPTRLRLIYLADGQLLDYSPDRDELLRF FT EKTLMAIWRAIQSAGETGDFRPNPSRLCDWCPHQQRCPAFGGTPPPYPGWPTEPAA" FT CDS complement(154670..155152) FT /transl_table=11 FT /gene="Mb2144c" FT /locus_tag="Mb2144c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb2144c, -, len: 160 aa. Equivalent to Rv2120c, len: FT 160 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 160 aa overlap). Probable conserved FT integral membrane protein, similar to hypothetical protein FT from Mesorhizobium loti (153 aa). Smith-Waterman scores: FT NP_104030.1 hypothetical protein [Mesorhizobium loti] FT >gi|14023209|dbj|BAB49816.1| (AP003000) Identities = 50/135 FT (37%)." FT /db_xref="GOA:Q7TZ06" FT /db_xref="InterPro:IPR008816" FT /db_xref="UniProtKB/TrEMBL:Q7TZ06" FT /protein_id="CAD96997.1" FT /translation="MTHVLVLLLALLIGVVAGLRSLTAPAVVSWAAFLGWINLHGTWAS FT WMGNFVTVVIVSVLAVAELVNDKRPKTPPRTVTPVFAVRIILGAFAGAVIGTAWGYRWG FT GLGAGVIGAVLGTMGGYQARTRLVAARGGHDLPIALLEDSVAVLGGFAIVAAAAAL" FT CDS complement(155231..156085) FT /transl_table=11 FT /gene="hisG" FT /locus_tag="Mb2145c" FT /product="Probable ATP phosphoribosyltransferase HisG" FT /EC_number="2.4.2.17" FT /note="Mb2145c, hisG, len: 284 aa. Equivalent to Rv2121c, FT len: 284 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 284 aa overlap). Probable hisG, ATP FT phosphoribosyltransferase (EC 2.4.2.17) (see citation FT below), similar to others e.g. HIS1_ECOLI|P10366 ATP FT phosphoribosyltransferase from Escherichia coli (299 aa), FT FASTA scores: opt: 351, E(): 4.5e-20, (31.8% identity in FT 289 aa overlap); etc." FT /db_xref="GOA:P60760" FT /db_xref="InterPro:IPR001348" FT /db_xref="UniProtKB/Swiss-Prot:P60760" FT /protein_id="CAD96998.1" FT /translation="MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEF FT FFLRPKDIAIYVGSGELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTT FT ADLAGMRIATAYPNLVRKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLS FT QHDLVAFGEPLCDSEAVLIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRS FT ALKKATAITPGLESPTIAPLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRF FT CRF" FT CDS complement(156088..156369) FT /transl_table=11 FT /gene="hisE" FT /locus_tag="Mb2146c" FT /standard_name="irg1" FT /product="Probable phosphoribosyl-AMP pyrophosphatase HisE" FT /EC_number="3.6.1.31" FT /note="Mb2146c, hisE, len: 93 aa. Equivalent to Rv2122c, FT len: 93 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 93 aa overlap). Probable hisE FT (alternate gene name: irg1), phosphoribosyl-AMP FT cyclohydrolase (EC 3.6.1.31) (see citation below), similar FT to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP FT cyclohydrolase (230 aa), FASTA scores; opt: 150, E(): FT 4e-08, (37.9% identity in 87 aa overlap); etc. Note that FT previously misnamed hisI." FT /db_xref="GOA:P0A5B2" FT /db_xref="InterPro:IPR008179" FT /db_xref="UniProtKB/Swiss-Prot:P0A5B2" FT /protein_id="CAD96999.1" FT /translation="MQQSLAVKTFEDLFAELGDRARTRPADSTTVAALDGGVHALGKKL FT LEEAGEVWLAAEHESNDALAEEISQLLYWTQVLMISRGLSLDDVYRKL" FT CDS 156496..157890 FT /transl_table=11 FT /gene="PPE37" FT /locus_tag="Mb2147" FT /standard_name="irg2" FT /product="conserved hypothetical protein, PPE" FT /note="Mb2147, PPE37, len: 464 aa. Equivalent to Rv2123, FT len: 473 aa, from Mycobacterium tuberculosis strain H37Rv, FT (97.9% identity in 473 aa overlap). PPE37 (alternate gene FT name: irg2), member of the Mycobacterium tuberculosis PPE FT family of proteins but the C-terminus is not repetitive. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 27 FT bp in-frame deletion leads to a slightly shorter product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (464 aa versus 473 aa)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7VEQ6" FT /protein_id="CAD97000.1" FT /translation="MTFPMWFAVPPEVPSAWLSTGMGPGPLLAAQYTEIATELASVLAA FT VQASSWQGPSADRFVVAHQPFRYWLTHAATVATAAAAAHETAAAGYTSALGGMPTLAEL FT AANHAMHGALVTTNFFGVNTIPIALNEADYLRMWIQAATVMSHYQAVAHESVAATPSTP FT PAPQIVTSAASSAASISFPDPTKLILQLLKDFLELLRYLAVELLPGPLGDLIAQVLDWF FT ISFVSGPVFTFLAYLVLDPLIYFGPFAPLTSPVLLPAGLTGLAGLGAVSGPAGPMVERV FT HSDGPSRQSWPAATGVTLVGTNPAALVTTPAPAPTTSAAPTAPSTPGSSAAQGLYAVGG FT PDGEGFNPIAKTTALAGVTTDAAAPAAKLPGDQAQSSASKATRLRRRLRQHRFEFLADD FT GRLTMPNTPEMADVAAGNRGLDALGFAGTIPKSAPGSATGLTHLGGGFADVLSQPMLPH FT TWDGSD" FT CDS complement(157887..161465) FT /transl_table=11 FT /gene="metH" FT /locus_tag="Mb2148c" FT /product="Probable 5-methyltetrahydrofolate--homocystein FT methyltransferase MetH (Methionine synthase, vitamin-B12 FT dependent isozyme) (MS)" FT /EC_number="2.1.1.13" FT /note="Mb2148c, metH, len: 1192 aa. Equivalent to Rv2124c, FT len: 1192 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1192 aa overlap). Probable metH, FT methionine synthase (EC 2.1.1.13), similar to many e.g. FT METH_ECOLI|P13009 5-methyltetrahydrofolate--homocystein FT methyltransferase from Escherichia coli (1226 aa), FASTA FT scores: opt: 1446, E(): 0, (32.1% identity in 1223 aa FT overlap); etc. Contains PS00178 Aminoacyl-transfer RNA FT synthetases class-I signature. BELONGS TO THE VITAMIN-B12 FT DEPENDENT METHIONINE SYNTHASE FAMILY." FT /db_xref="GOA:Q7VEQ5" FT /db_xref="HSSP:1BMT" FT /db_xref="InterPro:IPR004223" FT /db_xref="UniProtKB/TrEMBL:Q7VEQ5" FT /protein_id="CAD97001.1" FT /translation="MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGL FT EGCNEILNETRPDVLETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGT FT AIARRVADELGSPDRKRYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAI FT LVETCQDLLQLKAAVLGSRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPL FT GVDMIGLNCATGPAEMSEHLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEA FT LAGFIAEFGLSLVGGCCGTTPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQD FT ASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVAD FT MKALASRLATSSTLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMA FT LVAEHGAAVVALTIDEEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIAT FT GQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAG FT LDSAIVHASKILPMNRIPEEQRNVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDR FT LAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGS FT GQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGRIVLATVKGDVHDIGKNLVDIVL FT SNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEK FT FPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEA FT IKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGL FT AVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAH FT AAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGRFLCIADFIRSRELAAER FT GEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREEL FT KFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLEPERIGVTLS FT EELQLHPEQSTDAFVLHHPEAKYFNV" FT CDS 161691..162569 FT /transl_table=11 FT /gene="Mb2149" FT /locus_tag="Mb2149" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2149, -, len: 292 aa. Equivalent to Rv2125, len: FT 292 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 292 aa overlap). Conserved hypothetical FT protein. Corresponds to Mycobacterium leprae hypothetical FT protein e.g. TR:Q49797 B2126_F1_36 (317 aa), FASTA scores; FT opt: 1648, E(): 0, 84.1% identity in 290 aa overlap. Very FT similar to Mycobacterium tuberculosis hypothetical protein FT Rv2714" FT /db_xref="InterPro:IPR008492" FT /db_xref="UniProtKB/TrEMBL:Q7TZ05" FT /protein_id="CAD97002.1" FT /translation="MTPSEGNAPLPELHNTVVVAAFEGWNDAGDAASDAVAHLAASWQA FT LPIVEIDDEAYYDYQVNRPVIRQVDGVTRELQWPAMRISHCRPPGSDRDVVLMCGVEPN FT MRWRTFCDELLAVIDKLNVDTVVILGALLADTPHTRPVPVSGAAYSAASARQFGLQETR FT YEGPTGIAGVFQSACVGAGIPAVTFWAAVPHYVSHPPNPKATIALLRRVEDVLDVEVPL FT ADLPAQAEAWEREITETIAEDHELAEYVQTLEQHGDAAVDMNEALGNIDGDALAAEFER FT YLRRRRPGFGR" FT CDS complement(162600..163667) FT /transl_table=11 FT /gene="PE_PGRS37" FT /locus_tag="Mb2150c" FT /product="conserved hypothetical protein, PE_PGRS" FT /note="Mb2150c, -, len: 256 aa. Equivalent to Rv2126c, len: FT 256 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 256 aa overlap). Possible PE_PGRS pseudogene FT fragment, similar to the Gly-rich C-terminus of many FT members of the Mycobacterium tuberculosis PGRS family e.g. FT MTCY441.04c (778 aa), FASTA scores; opt: 935, E(): 4.4e-18, FT 56.1% identity in 271 aa overlap" FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7VEL2" FT /protein_id="CAD97003.1" FT /translation="MAGIGSAISAANALVAGPTTALAADRRRRGVDGYRGAVRRECAGI FT PTDQRAGGRVSRAVCRGPNLGWRVVRGRRDRQRHVGTRSAQCRQCAHPGIVGRPLIGDG FT ANGGPGQPGGPGGLLYGNGGHGGAGAAGQDRGAGNSAGLIGNGGAGGAGGNGGIGGAGA FT PGGLGGDGGKGGFADEFTGGFAQGGRGGFGGNGNTGASGGMGGAGGAGGAGGAGGLLIG FT DGGAGGAGGIGGAGGVGGGGGAGGTGGGGVASAFGGGNAFGGRGGDGGDGGDGGTGGAG FT GARGAGGAGGAGGWLSGHSGAHGAMGSGGEGGAGGGGGARGEAGAGGGTSTGTNPGKAG FT APGTQGDSGDPGPPG" FT CDS 164014..165483 FT /transl_table=11 FT /gene="ansP1" FT /locus_tag="Mb2151" FT /product="Probable L-asparagine permease ansP1" FT /note="Mb2151, ansP1, len: 489 aa. Equivalent to Rv2127, FT len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 489 aa overlap). Probable ansP1, FT L-asparagine permease, integral membrane protein highly FT similar to many eg. ANSP_ECOLI P77610 L-asparagine permease FT (L-asparagine transport protein) (516 aa), FASTA scores: FT opt: 1880, E(): 0, (60.3% identity in 463 aa overlap); etc. FT Also highly similar to Mycobacterium tuberculosis permeases FT Rv0346c|MTCY13E10.06c, (72.1% identity in 473 aa overlap) FT and Rv1704c|MTCI125.26c|cycA. Contains PS00218 Amino acid FT permeases signature. SEEMS TO BELONG TO THE APC FAMILY." FT /db_xref="GOA:Q7VEQ4" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEQ4" FT /protein_id="CAD97004.1" FT /translation="MSAASQRVDAFGEEAGYHKGLKPRQLQMIGIGGAIGTGLFLGASG FT RLAKAGPGLFLVYGVCGVFVFLILRALGELVLHRPSSGSFVSYAREFFGEKAAYAVGWM FT YFLHWAMTSIVDTTAIATYLQRWTIFTVVPQWILALIALTVVLSMNLISVEWFGELEFW FT AALIKVLALMAFLVVGTVFLAGRYPVDGHSTGLSLWNNHGGLFPTSWLPLLIVTSGVVF FT AYSAVELVGTAAGETAEPEKIMPRAINSVVARIAIFYVGSVALLALLLPYTAYKAGESP FT FVTFFSKIGFHGAGDLMNIVVLTAALSSLNAGLYSTGRVMHSIAMSGSAPRFTARMSKS FT GVPYGGIVLTAVITLFGVALNAFKPGEAFEIVLNMSALGIIAGWATIVLCQLRLHKLAN FT AGIMQRPRFRMPFSPYSGYLTLLFLLVVLVTMASDKPIGTWTVATLIIVIPALTAGWYL FT VRKRVMAVARERLGHTGPFPAVANPPVRSRD" FT CDS 165483..165686 FT /transl_table=11 FT /gene="Mb2152" FT /locus_tag="Mb2152" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb2152, -, len: 67 aa. Equivalent to Rv2128, len: 67 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 67 aa overlap). Probable conserved FT transmembrane protein." FT /db_xref="GOA:Q7TZ04" FT /db_xref="UniProtKB/TrEMBL:Q7TZ04" FT /protein_id="CAD97005.1" FT /translation="MLRRGESIIRNRYASKPPLYGMAMVFLAMAVVAVTAYFRMGWWSI FT IGYAAAAIIGVIGFALAFRDLS" FT CDS complement(165706..166587) FT /transl_table=11 FT /gene="Mb2153c" FT /locus_tag="Mb2153c" FT /product="Probable oxidoreductase" FT /EC_number="1.-.-.-" FT /note="Mb2153c, -, len: 293 aa. Equivalent to Rv2129c, len: FT 293 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 293 aa overlap). Probable FT oxidoreductase (EC 1.-.-.-), similar to many e.g. FT FABG_SYNY3|P73826 3-oxoacyl-[acyl-carrier protein] FT reductase (240 aa), FASTA scores: opt: 241, E(): 5.1e-17, FT (32.7% identity in 196 aa overlap); etc. Also similar to a FT number of other Mycobacterium tuberculosis oxidoreductases FT e.g. MTCY210.04 (34.1% identity in 217 aa overlap)." FT /db_xref="GOA:Q7VEQ3" FT /db_xref="HSSP:1BDB" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7VEQ3" FT /protein_id="CAD97006.1" FT /translation="MTSLQGKVVFITGAARGIGAEVARRLHNKGAKLVLTDLSKSELAV FT MGAELGGDDRLLTVVADVRDLPAMQAAAETAVERFGGIDVVVANAGIASYGSVLKVDPQ FT AFRRVLDVNLLGNFHTVRATLPALIDRRGYVLIVSSLAAFAAPPGMAPYNMSKAGNEHF FT ANALRLEVAHLGVSVGSAHMSWIDTALVRDTKADLPAFAELLARLPWPLNKTTSVNKCA FT AAFVNGIEGRKDRVYCPGWVALFRWLKPLLSTRVGQRPIRNTVAKLMPQMDAEVAALGR FT FASAYTESLENS" FT CDS complement(166613..167857) FT /transl_table=11 FT /gene="cysS2" FT /locus_tag="Mb2154c" FT /product="Probable cysteinyl-tRNA synthetase CysS2" FT /note="Mb2154c, cysS2, len: 414 aa. Equivalent to Rv2130c, FT len: 414 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 414 aa overlap). Probable cysS2, FT cysteinyl-tRNA synthetase, similar to many e.g. FT SYC_ECOLI|P21888 cysteinyl-tRNA synthetase from Escherichia FT coli (461 aa), FASTA scores: opt: 535, E(): 0, (37.0% FT identity in 370 aa overlap); etc. Also similar to FT Mycobacterium tuberculosis cysS|Rv3580c|MTCY06G11.27c, FT (35.8% identity in 372 aa overlap)." FT /db_xref="GOA:P67018" FT /db_xref="HSSP:1LI5" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:P67018" FT /protein_id="CAD97007.1" FT /translation="MQSWYCPPVPVLPGRGPQLRLYDSADRQVRPVAPGSKATMYVCGI FT TPYDATHLGHAATYVTFDLIHRLWLDLGHELHYVQNITDIDDPLFERADRDGVDWRDLA FT QAEVALFCEDMAALRVLPPQDYVGATEAIAEMVELIEKMLACGAAYVIDREMGEYQDIY FT FRADATLQFGYESGYDRDTMLRLCEERGGDPRRPGKSDELDALLWRAARPGEPSWPSPF FT GPGRPGWHVECAAIALSRIGSGLDIQGGGSDLIFPHHEFTAAHAECVSGERRFARHYVH FT AGMIGWDGHKMSKSRGNLVLVSALRAQDVEPSAVRLGLLAGHYRADRFWSQQVLDEATA FT RLHRWRTATALPAGPAAVDVVARVRRYLADDLDTPKAIAALDGWVTDAVEYGGHDAGAP FT KLVATAIDALLGVDL" FT CDS complement(167915..168718) FT /transl_table=11 FT /gene="cysQ" FT /locus_tag="Mb2155c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2155c, cysQ, len: 267 aa. Equivalent to Rv2131c, FT len: 267 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 267 aa overlap). cysQ, equivalent to FT Mycobacterium leprae CYSQ_MYCLE P46726 cysQ protein homolog FT (289 aa). Contains inositol monophosphatase family FT signature 1 (PS00629), significance uncertain. FASTA best: FT CYSQ_MYCLE P4672 6 cysq protein homolog (289 aa) opt: 1374, FT E(): 0; (77.3% identity in 264 aa overlap)" FT /db_xref="GOA:P65164" FT /db_xref="InterPro:IPR000760" FT /db_xref="UniProtKB/Swiss-Prot:P65164" FT /protein_id="CAD97008.1" FT /translation="MVSPAAPDLTDDLTDAELAADLAADAGKLLLQVRAEIGFDQPWTL FT GEAGDRQANSLLLRRLQAERPGDAVLSEEAHDDLARLKSDRVWIIDPLDGTREFSTPGR FT DDWAVHIALWRRSSNGQPEITDAAVALPARGNVVYRTDTVTSGAAPAGVPGTLRIAVSA FT TRPPAVLHRIRQTLAIQPVSIGSAGAKAMAVIDGYVDAYLHAGGQWEWDSAAPAGVMLA FT AGMHASRLDGSPLRYNQLDPYLPDLLMCRAEVAPILLGAIADAWR" FT CDS 168809..169039 FT /transl_table=11 FT /gene="Mb2156" FT /locus_tag="Mb2156" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2156, -, len: 76 aa. Equivalent to Rv2132, len: 76 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 76 aa overlap). Conserved hypothetical protein. FT Function unknown but belongs to Mycobacterium tuberculosis FT protein family including Rv2871, Rv1241, Rv3321c, Rv1113, FT Rv0657c, Rv1560, Rv2104c, etc. Similarity to Mycobacterium FT tuberculosis protein Rv2871 (AL021924|MTV020_4, 84 aa). FT FASTA score: opt: 142, E(): 0.00036; 41.8% identity in 55 FT aa overlap" FT /db_xref="GOA:Q7TZ03" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/TrEMBL:Q7TZ03" FT /protein_id="CAD97009.1" FT /translation="MRTTVSLADDVAAAVQRLRKERSIGLSEAVNELIRAGLTKRQVAN FT RFQQQTYDMGEGIDYSNIGDAIETLDGPASG" FT CDS complement(169249..170037) FT /transl_table=11 FT /gene="Mb2157c" FT /locus_tag="Mb2157c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2157c, -, len: 262 aa. Equivalent to Rv2133c, len: FT 262 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 262 aa overlap). Conserved hypothetical FT protein. Function: unknown but equivalent to hypothetical FT Mycobacterium leprae protein, Q49774. FASTA best: Q49774 FT B2126_C1_150 (262 aa) opt: 1447, E(): 0; (79.0% identity in FT 262 aa overlap)" FT /db_xref="GOA:Q7TZ02" FT /db_xref="InterPro:IPR000403" FT /db_xref="UniProtKB/TrEMBL:Q7TZ02" FT /protein_id="CAD97010.1" FT /translation="MLADGELTVLGRIRSASNATFLCESTLGLRSLHCVYKPVSGERPL FT WDFPDGTLAGRELSAYLVSTQLGWNLVPHTIIRDGPAGIGMLQLWVQQPGDAVDSDPLP FT GPDLVDLFPAHRPRPGYLPVLRAYDYAGDEVVLMHADDIRLRRMAVFDVLINNADRKGG FT HILCGIDGQVYGVDHGLCLHVENKLRTVLWGWAGKPIDDQILQAVAGLADALGGPLAEA FT LAGRIAAAEIGALRRRAQSLLDQPVMPGPNGHRPIPWPAF" FT CDS complement(170048..170635) FT /transl_table=11 FT /gene="Mb2158c" FT /locus_tag="Mb2158c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2158c, -, len: 195 aa. Equivalent to Rv2134c, len: FT 195 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 195 aa overlap). Conserved hypothetical FT protein. Function: unknown but equivalent to hypothetical FT Mycobacterium leprae protein, Q49789. FASTA best: Q49789 FT B2126_C3_228, opt: 1192, E( ): 0 (91.1% identity in 192 aa FT overlap)" FT /db_xref="UniProtKB/TrEMBL:Q7TZ01" FT /protein_id="CAD97011.1" FT /translation="MARAIHVFRTPDRFVAGTVGQPGNRTFYLQAVHDSRVVSVVLEKQ FT QVAVLAERIGALLFEVNRRFGTPVPPEPTEIDDLSPLIMPVDAEFRVGTMGLGWDSEAQ FT SVVVELLAVTDAEFDASVVLDDTEEGPDAVRVFLTPESARQFATRSYRVISAGRPPCPL FT CDEPLDPEGHICARTNGYRRDVLLGSGDDPAG" FT CDS complement(170699..171409) FT /transl_table=11 FT /gene="Mb2159c" FT /locus_tag="Mb2159c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2159c, -, len: 236 aa. Equivalent to Rv2135c, len: FT 236 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 236 aa overlap). Conserved hypothetical FT protein. Function: unknown but equivalent to hypothetical FT Mycobacterium leprae protein, Q49773. FASTA best: Q49773 FT B2126_C1_148 opt: 1183, E() : 0; (74.8% identity in 250 aa FT overlap), also similar in C-terminus to PMG2_ECOLI P36942 FT probable phosphoglycerate mutase 2 (215 aa), FASTA scores; FT opt: 212, E(): 2.5e-07 27.9% identity in 190 aa overlap; FT and to Rv2228 and Rv2419c" FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/TrEMBL:Q7TZ00" FT /protein_id="CAD97012.1" FT /translation="MTVILLRHARSTSNTAGVLAGRSGVDLDEKGREQATGLIDRIGDL FT PIRAVASSPMLRCQRTVEPLAEALCLEPLIDDRFSEVDYGEWTGRKIGDLVDEPLWRVV FT QAHPSAAVFPGGEGLAQVQTRAVAAVREHDRRLADQHGHDVLWLACTHGDVIKAVIADA FT FGMHLDSFQRITADPGSVSVVRYTQLRPFVLHVNHTGARLAPALQAAASAQGASPEPNA FT AVPPGDAVIGGSTD" FT CDS complement(171406..172236) FT /transl_table=11 FT /gene="Mb2160c" FT /locus_tag="Mb2160c" FT /product="Possible conserved transmembrane protein" FT /note="Mb2160c, -, len: 276 aa. Equivalent to Rv2136c, len: FT 276 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 276 aa overlap). Possible conserved FT transmembrane protein, very similar to hypothetical FT Mycobacterium leprae protein Q49783. FASTA best: Q49783 FT B2126_C2_190 opt: 1023, E(): 0; (82.4% identity in 187 aa FT over lap) similar to BACA_ECOLI P31054 bacitracin FT resistance protein (273 aa) opt: 477, E(): 7e-26, (35.6% FT identity in 267 aa overlap)" FT /db_xref="GOA:Q7VEQ2" FT /db_xref="InterPro:IPR003824" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEQ2" FT /protein_id="CAD97013.1" FT /translation="MSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTA FT VSQLGTEAAVVIYFARDIVRILSAWVHGLVVKAHRNTDYRLGWYVIIGTIPICILGLFF FT KDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLALVP FT GVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQ FT LLVATLIAFVLGLTAVAWLLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT" FT CDS complement(172300..172713) FT /transl_table=11 FT /gene="Mb2161c" FT /locus_tag="Mb2161c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2161c, -, len: 137 aa. Equivalent to Rv2137c, len: FT 137 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 137 aa overlap). Conserved hypothetical FT protein. C-terminus is very similar to hypothetical FT Mycobacterium leprae protein B2126_C2_188 (150 aa). FASTA FT best: Q49782 B2126_C2_188. (150 aa) opt: 469, E(): 9.6e-28; FT (77.2% identity in 101 aa overlap)" FT /db_xref="UniProtKB/TrEMBL:Q7TYZ9" FT /protein_id="CAD97014.1" FT /translation="MRNMKSTSHESESGKLLSISSCRPREMVLQRYSLGMTVTADRHLA FT DKREEFAVEDISTGIFASGYGQVGDGRSFSFHIEHRSLVVEIYRPRVAGPVPQAEDVVA FT MAVRGLVDIDLTDERSLAAAVRDSVASAAPVSR" FT CDS 172728..173804 FT /transl_table=11 FT /gene="lppL" FT /locus_tag="Mb2162" FT /product="Probable conserved lipoprotein LppL" FT /note="Mb2162, lppL, len: 358 aa. Equivalent to Rv2138, FT len: 358 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 358 aa overlap). Probable lppL, FT conserved lipoprotein, with appropriately placed FT lipoprotein signature (PS00013) strongly similar to FT hypothetical Mycobacterium leprae protein, Q49806. FASTA FT best: Q49806 B2126_F3_142. (298 aa) opt: 1495, E(): 0; FT (75.3% identity in 300 aa overlap)." FT /db_xref="InterPro:IPR015943" FT /db_xref="UniProtKB/TrEMBL:Q7VEQ1" FT /protein_id="CAD97015.1" FT /translation="MLTGNKPAVQRRFIGLLMLSVLVAGCSSNPLANFAPGYPPTIEPA FT QPAVSPPTSQDPAGAVRPLSGHPRAALFDNGTRQLVALRPGADSAAPASIMVFDDVHVA FT PRVIFLPGPAAALTSDDHGTAFLAARGGYFVADLSSGHTARVNVADAAHTDFTAIARRS FT DGKLVLGSADGAVYTLAKNPAVDPASGAATVASRTKIFARVDALVTQGNTTVVLDRGQT FT SVTTIGADGHAQQALRAGQGATTMAADPLGRVLIADTRGGQLLVYGVDPLILRQAYPVR FT QAPYGLAGSRELAWVSQTASNTVIGYDLTTGIPVEKVRYPTVQQPNSLAFDETSDTLYV FT VSGSGAGSRFIEHAAGTR" FT CDS 174118..175191 FT /transl_table=11 FT /gene="pyrD" FT /locus_tag="Mb2163" FT /product="dihydroorotate dehydrogenase" FT /EC_number="1.3.3.1" FT /note="Mb2163, pyrD, len: 357 aa. Equivalent to Rv2139, FT len: 357 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 357 aa overlap). Probable pyrD, FT dihydroorotate dehydrogenase (EC 1.3.3.1); contains FT dihydroorotate dehydrogenase signatures 1 and 2 (PS00911, FT PS00912). FASTA best: PYRD_MYCLE P46727 dihydroorotate FT dehydrogenase (309 aa) opt: 1653, E(): 0; (82.6% identity FT in 304 aa overlap)" FT /db_xref="GOA:P65909" FT /db_xref="HSSP:1D3G" FT /db_xref="InterPro:IPR001295" FT /db_xref="UniProtKB/Swiss-Prot:P65909" FT /protein_id="CAD97016.1" FT /translation="MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPT FT DPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRL FT FRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASA FT RMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDL FT DDIADLAVELDLAGIVATNTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDR FT VGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGG FT FGSLHEAVGSARRRQPS" FT CDS complement(175196..175726) FT /transl_table=11 FT /gene="TB18.6" FT /locus_tag="Mb2164c" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB18.6" FT /note="Mb2164c, TB18.6, len: 176 aa. Equivalent to Rv2140c, FT len: 176 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 176 aa overlap). TB18.6, conserved FT hypothetical protein; shows good similarity to hypothetical FT proteins from Streptomyces coelicolor (177 aa; 58% FT identity) >emb|CAC32358.1| (AL583945) and to 17.1 kd FT Escherichia coli protein YbhB. FASTA best: YBHB_ECOLI FT P12994 hypothetical 17.1 kd protein (158 aa) opt: 465 E( ): FT 2e-23; (46.2% identity in 156 aa overlap)." FT /db_xref="HSSP:1FUX" FT /db_xref="InterPro:IPR005247" FT /db_xref="UniProtKB/Swiss-Prot:P67227" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97017.1" FT /translation="MTTSPDPYAALPKLPSFSLTSTSITDGQPLATPQVSGIMGAGGAD FT ASPQLRWSGFPSETRSFAVTVYDPDAPTLSGFWHWAVANLPANVTELPEGVGDGRELPG FT GALTLVNDAGMRRYVGAAPPPGHGVHRYYVAVHAVKVEKLDLPEDASPAYLGFNLFQHA FT IARAVIFGTYEQR" FT CDS complement(175774..177120) FT /transl_table=11 FT /gene="Mb2165c" FT /locus_tag="Mb2165c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2165c, -, len: 448 aa. Equivalent to Rv2141c, len: FT 448 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 448 aa overlap). Conserved hypothetical FT protein. Shows some similarity to conserved hypothetical FT proteins and to acetylornithine deacetylase and FT succinyl-diaminopimelate desuccinylase and contains FT ArgE/dapE/ACY1/CPG2/yscS family signature 1 (PS00758). FT FASTA best: CBPS_YEAST P27614 carboxypeptidases precursor FT (576 aa) opt: 234, E(): 4.3e-08; (24.3% identity in 412 aa FT overlap). Previously named dapE2" FT /db_xref="GOA:Q7TYZ8" FT /db_xref="InterPro:IPR001261" FT /db_xref="UniProtKB/TrEMBL:Q7TYZ8" FT /protein_id="CAD97018.1" FT /translation="MTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARW FT VAEQLAEVGYQPEYVESGAPGRGNVFARLAGADSSRGALLIHGHLDVVPAEPAEWSVHP FT FSGAIEDGYVWGRGAVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGKYGS FT HWLVDNRPDLFDGITEAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRA FT GHGSMVHDQNAVTAVCEAVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAG FT TIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPATAEAVVDCRVLPGRRAAFEAEVD FT ALIGPDVTREWVSDLPSYETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFAR FT LGIRCFGFSPLRLPPDLDFTSLFHGVDERVPIDGLRFGTEVLTHLLTHC" FT tRNA 177501..177586 FT /gene="leuU" FT /locus_tag="leuU" FT /note="leuU, len: 86 nt. Equivalent to leuU, len: 86 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 86 nt overlap). leu-tRNA, anticodon gag." FT CDS complement(177707..178024) FT /transl_table=11 FT /gene="Mb2166c" FT /locus_tag="Mb2166c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb2166c, -, len: 105 aa. Equivalent to Rv2142c, len: FT 105 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 105 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR007712" FT /db_xref="UniProtKB/TrEMBL:Q7TYZ7" FT /protein_id="CAD97019.1" FT /translation="MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRI FT PQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAIDILAVRHGMENPNAVEAEISGRTF FT E" FT CDS 178491..179549 FT /transl_table=11 FT /gene="Mb2167" FT /locus_tag="Mb2167" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2167, -, len: 352 aa. Equivalent to Rv2143, len: FT 352 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 352 aa overlap). Conserved hypothetical FT protein, strongly similar to two hypothetical mycobacterial FT proteins Rv2030c 2.1e-50 and Rv0571c from position 120 FT (Q50819; Q50111). FASTA best: Q50819 opt: 882, E() 0; FT (61.1% identity in 226 aa overlap). Also similar to FT AL021942|MTV039_9 (443 aa), FASTA scores: opt: 592, E(): FT 5e-30; 46.9% identity in 224 aa overlap" FT /db_xref="UniProtKB/TrEMBL:Q7TYZ6" FT /protein_id="CAD97020.1" FT /translation="MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDP FT AENESLLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGLLPPG FT CHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLADELASYRGRDRLL FT VLGLARGGVPVGWEVASALGAELDVFLVRKLGVPQWRELAMGALASGGGVVMNDDVVSS FT LRITDQQVRAAIDSETAELQRRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRT FT IRATGPESIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDEVR FT ELLATPTTGAAT" FT CDS complement(179679..180035) FT /transl_table=11 FT /gene="Mb2168c" FT /locus_tag="Mb2168c" FT /product="Probable transmembrane protein" FT /note="Mb2168c, -, len: 118 aa. Equivalent to Rv2144c, len: FT 118 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 118 aa overlap). Probable transmembrane FT protein." FT /db_xref="GOA:Q7VEQ0" FT /db_xref="UniProtKB/TrEMBL:Q7VEQ0" FT /protein_id="CAD97021.1" FT /translation="MLIIALVLALIGLLALVFAVVTSNQLVAWVCIGASVLGVALLIVD FT ALRERQQGGADEADGAGETGVAEEADVDYPEEAPEESQAVDAGVIGSEEPSEEASEATE FT ESAVSADRSDDSAK" FT CDS complement(180130..180912) FT /transl_table=11 FT /gene="wag31" FT /locus_tag="Mb2169c" FT /standard_name="ag84" FT /product="CONSERVED HYPOTHETICAL PROTEIN WAG31" FT /note="Mb2169c, wag31, len: 260 aa. Equivalent to Rv2145c, FT len: 260 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 260 aa overlap). wag31 (alternate gene FT name: ag84). Function unknown but corresponds to antigen 84 FT of Mycobacterium tuberculosis (wag31) (see first citation FT below). Predicted to contain significant amount of coiled FT coil structure. Some similarity to Rv1682 and Rv2927c. FT FASTA best: AG84_MYCTU P46816 antigen 84." FT /db_xref="GOA:P0A5N3" FT /db_xref="InterPro:IPR019933" FT /db_xref="UniProtKB/Swiss-Prot:P0A5N3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97022.1" FT /translation="MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVENELTRLIEE FT NSDLRQRINELDQELAAGGGAGVTPQATQAIPAYEPEPGKPAPAAVSAGMNEEQALKAA FT RVLSLAQDTADRLTNTAKAESDKMLADARANAEQILGEARHTADATVAEARQRADAMLA FT DAQSRSEAQLRQAQEKADALQADAERKHSEIMGTINQQRAVLEGRLEQLRTFEREYRTR FT LKTYLESQLEELGQRGSAAPVDSNADAGGFDQFNRGKN" FT CDS complement(181180..181470) FT /transl_table=11 FT /gene="Mb2170c" FT /locus_tag="Mb2170c" FT /product="Possible conserved transmembrane protein" FT /note="Mb2170c, -, len: 96 aa. Equivalent to Rv2146c, len: FT 96 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 96 aa overlap). Possible conserved FT transmembrane protein, orthologs present in Mycobacterium FT leprae, ML0921 (96 aa) and Streptomyces coelicolor. Second FT start taken GTG alternative upstream but much less probable FT in TBparse. FASTA best: Q44935 SIMILAR TO A HYPOTHETICAL FT INTEGRAL MEMBRANE PROT EIN (97 aa) opt: 105, E(): 0.093; FT (25.3% identity in 87 aa overlap). >emb|CAC31302.1| FT (AL583920) possible membrane protein ML0921 [Mycobacterium FT leprae] E(): 5e-32 (76% identity in 96 aa overlap)" FT /db_xref="GOA:Q7VEP9" FT /db_xref="InterPro:IPR003425" FT /db_xref="UniProtKB/TrEMBL:Q7VEP9" FT /protein_id="CAD97023.1" FT /translation="MVVFFQILGFALFIFWLLLIARVVVEFIRSFSRDWRPTGVTVVIL FT EIIMSITDPPVKVLRRLIPQLTIGAVRFDLSIMVLLLVAFIGMQLAFGAAA" FT CDS complement(181632..182357) FT /transl_table=11 FT /gene="Mb2171c" FT /locus_tag="Mb2171c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2171c, -, len: 241 aa. Equivalent to Rv2147c, len: FT 241 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 241 aa overlap). Conserved hypothetical FT protein, similar to conserved hypothetical proteins in FT Mycobacterium leprae ML0920 (210 aa) and Streptomyces FT coelicolor. FASTA scores: >emb|CAC31301.1| (AL583920) FT hypothetical protein ML0920 hypothetical protein (210 aa) FT opt: 1242, E(): 5.7e-74; 83.486% identity in 218 aa FT overlap" FT /db_xref="GOA:Q7TYZ5" FT /db_xref="InterPro:IPR007561" FT /db_xref="UniProtKB/Swiss-Prot:Q7TYZ5" FT /protein_id="CAD97024.1" FT /translation="MNSHCSHTFITDNRSPRARRGHAMSTLHKVKAYFGMAPMEDYDDE FT YYDDRAPSRGYARPRFDDDYGRYDGRDYDDARSDSRGDLRGEPADYPPPGYRGGYADEP FT RFRPREFDRAEMTRPRFGSWLRNSTRGALAMDPRRMAMMFEDGHPLSKITTLRPKDYSE FT ARTIGERFRDGSPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADV FT DVSPEERRRIAETGFYAYQ" FT CDS complement(182354..183130) FT /transl_table=11 FT /gene="Mb2172c" FT /locus_tag="Mb2172c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2172c, -, len: 258 aa. Equivalent to Rv2148c, len: FT 258 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 258 aa overlap). Conserved hypothetical FT protein; should belong to the YGGS/YBL036C/F09E5.8 family. FT FASTA best: AB003132|AB003132_5 Corynebacterium glutamicum FT gene (221 aa) opt: 440, E(): 2.3e-23; 42.8% identity in 236 FT aa overlap; and YPI1_VIBAL P52055 hypothetical protein in FT pilt-proc intergenic region in Vibrio alginolyticus. opt: FT 266, E(): 1.8e-11; 27.9% identity in 244 aa overlap." FT /db_xref="InterPro:IPR011078" FT /db_xref="UniProtKB/Swiss-Prot:P67084" FT /protein_id="CAD97025.1" FT /translation="MAADLSAYPDRESELTHALAAMRSRLAAAAEAAGRNVGEIELLPI FT TKFFPATDVAILFRLGCRSVGESREQEASAKMAELNRLLAAAELGHSGGVHWHMVGRIQ FT RNKAGSLARWAHTAHSVDSSRLVTALDRAVVAALAEHRRGERLRVYVQVSLDGDGSRGG FT VDSTTPGAVDRICAQVQESEGLELVGLMGIPPLDWDPDEAFDRLQSEHNRVRAMFPHAI FT GLSAGMSNDLEVAVKHGSTCVRVGTALLGPRRLRSP" FT CDS complement(183136..183888) FT /transl_table=11 FT /gene="yfiH" FT /locus_tag="Mb2173c" FT /product="conserved hypothetical protein yfiH" FT /note="Mb2173c, yfiH, len: 250 aa. Equivalent to Rv2149c, FT len: 250 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 250 aa overlap). yfiH; corresponds to FT hypothetical 25.3 kDa YfiH protein in ftsZ 3' region of FT Streptomyces griseus, and to YfiH proteins in other FT bacteria. Belongs to UPF0124 Family. FASTA best: YFIH_STRGR FT P45496, (246 aa) opt: 722, E(): 1.9e-37; (49.4% identity in FT 245 aa overlap)" FT /db_xref="InterPro:IPR003730" FT /db_xref="UniProtKB/Swiss-Prot:P67257" FT /protein_id="CAD97026.1" FT /translation="MLASTRHIARGDTGNVSVRIRRVTTTRAGGVSAPPFDTFNLGDHV FT GDDPAAVAANRARLAAAIGLPGNRVVWMNQVHGDRVELVDQPRNTALDDTDGLVTATPR FT LALAVVTADCVPVLMADARAGIAAAVHAGRAGAQRGVVVRALEVMLSLGAQVRDISALL FT GPAVSGRNYEVPAAMADEVEAALPGSRTTTAAGTPGVDLRAGIACQLRDLGVESIDVDP FT RCTVADPTLFSHRRDAPTGRFASLVWME" FT CDS complement(183899..185038) FT /transl_table=11 FT /gene="ftsZ" FT /locus_tag="Mb2174c" FT /product="cell division protein FtsZ" FT /note="Mb2174c, ftsZ, len: 379 aa. Equivalent to Rv2150c, FT len: 379 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 379 aa overlap). ftsZ, cell division FT protein (see first citation below). Contains FtsZ protein FT signature 2 (PS01135). FASTA best: FTSZ_STRCO P45500 cell FT division protein FtsZ (399 aa) opt: 1674, E(): 0; (77.3% FT identity in 339 aa overlap)." FT /db_xref="GOA:P64171" FT /db_xref="HSSP:1OFU" FT /db_xref="InterPro:IPR003008" FT /db_xref="UniProtKB/Swiss-Prot:P64171" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97027.1" FT /translation="MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQ FT ALLMSDADVKLDVGRDSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGG FT GTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPN FT DRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTAL FT MGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQD FT AAHPDANIIFGTVIDDSLGDEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKL FT TSTLFEPVDAVSVPLHTNGATLSIGGDDDDVDVPPFMRR" FT CDS complement(185211..186155) FT /transl_table=11 FT /gene="ftsQ" FT /locus_tag="Mb2175c" FT /product="POSSIBLE CELL DIVISION PROTEIN FTSQ" FT /note="Mb2175c, ftsQ, len: 314 aa. Equivalent to Rv2151c, FT len: 314 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 314 aa overlap). Possible ftsQ, cell FT division protein, with some homology to FTSQ_STRGR|P45503 FT cell division protein ftsq homolog from Streptomyces FT griseus (208 aa), FASTA scores: opt: 204, E(): 4e-05; FT (30.6% identity in 193 aa overlap)." FT /db_xref="GOA:P64169" FT /db_xref="InterPro:IPR013685" FT /db_xref="UniProtKB/Swiss-Prot:P64169" FT /protein_id="CAD97028.1" FT /translation="MTEHNEDPQIERVADDAADEEAVTEPLATESKDEPAEHPEFEGPR FT RRARRERAERRAAQARATAIEQARRAAKRRARGQIVSEQNPAKPAARGVVRGLKALLAT FT VVLAVVGIGLGLALYFTPAMSAREIVIIGIGAVSREEVLDAARVRPATPLLQIDTQQVA FT DRVATIRRVASARVQRQYPSALRITIVERVPVVVKDFSDGPHLFDRDGVDFATDPPPPA FT LPYFDVDNPGPSDPTTKAALQVLTALHPEVASQVGRIAAPSVASITLTLADGRVVIWGT FT TDRCEEKAEKLAALLTQPGRTYDVSSPDLPTVK" FT CDS complement(186152..187636) FT /transl_table=11 FT /gene="murC" FT /locus_tag="Mb2176c" FT /product="UDP-N-acetylmuramate-alanine ligase MurC" FT /EC_number="6.3.2.8" FT /note="Mb2176c, murC, len: 494 aa. Equivalent to Rv2152c, FT len: 494 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 494 aa overlap). Probable murC, FT UDP-N-acetylmuramate-alanine ligase (EC 6.3.2.8). FASTA FT best: MURC_ECOLI P17952 (491 aa) opt: 764, E(): 0; (36.9% FT identity in 474 aa overlap)" FT /db_xref="GOA:P65473" FT /db_xref="HSSP:1GQY" FT /db_xref="InterPro:IPR013221" FT /db_xref="UniProtKB/Swiss-Prot:P65473" FT /protein_id="CAD97029.1" FT /translation="MSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKES FT RGVHALRARGALIRIGHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLR FT PAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHHGS FT GDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGAL FT VVCTDDPGGAALAQRATELGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELA FT TAQGPRVMRLSVPGRHMALNALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCG FT VGKASVRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGR FT ALNAADEVFVLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDV FT IVTMGAGDVTLLGPEILTALRVRANRSAPGRPGVLG" FT CDS complement(187633..188865) FT /transl_table=11 FT /gene="murG" FT /locus_tag="Mb2177c" FT /product="UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapep FT tide) pyrophosphoryl-undecaprenol-N-acetylglucosamine FT transferase MurG" FT /EC_number="2.4.1.-" FT /note="Mb2177c, murG, len: 410 aa. Equivalent to Rv2153c, FT len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 410 aa overlap). Probable MURG PROTEIN FT (UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) FT pyrophosphoryl-undecaprenol-N-acetylglucosamine FT transferase. FASTA score: MURG_BACSU P37585 murg protein FT (363 aa) opt: 494, E(): 1.1e-20; (27.9% identity in 365 aa FT overlap)" FT /db_xref="GOA:Q7VEP8" FT /db_xref="InterPro:IPR007235" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEP8" FT /protein_id="CAD97030.1" FT /translation="MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSLSVVLAGGGT FT AGHVEPAMAVADALVALDPRVRITALGTPRGLETRLVPQRGYHLELITAVPMPRKPGGD FT LARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIPVVI FT HEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAH FT FGFPDDARVLLVFGGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGD FT PPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALP FT VVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALA FT VATGAGARTTT" FT CDS complement(188862..190436) FT /transl_table=11 FT /gene="ftsW" FT /locus_tag="Mb2178c" FT /product="FtsW-like protein FtsW" FT /note="Mb2178c, ftsW, len: 524 aa. Equivalent to Rv2154c, FT len: 524 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 524 aa overlap). Probable ftsW, cell FT division protein, related to MTCY10H4.17c, 3.2e-17. FASTA FT best: SP5E_BACSU P07373 stage V sporulation protein E (366 FT aa) opt: 755, E(): 1.6e-33; (38.4% identity in 357 aa FT overlap)" FT /db_xref="GOA:P63763" FT /db_xref="InterPro:IPR013437" FT /db_xref="UniProtKB/Swiss-Prot:P63763" FT /protein_id="CAD97031.1" FT /translation="MLTRLLRRGTSDTDGSQTRGAEPVEGQRTGPEEASNPGSARPRTR FT FGAWLGRPMTSFHLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVG FT LIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLVLVPGIGKEANGSRGWFVVAGFSMQPS FT ELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVSMGIIL FT LGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQA FT KFALAQGGIFGDGLGQGVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTG FT MRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGLLPVTGLQLPLISAGGTSTAATL FT SLIGIIANAARHEPEAVAALRAGRDDKVNRLLRLPLPEPYLPPRLEAFRDRKRANPQPA FT QTQPARKTPRTAPGQPARQMGLPPRPGSPRTADPPVRRSVHHGAGQRYAGQRRTRRVRA FT LEGQRYG" FT CDS complement(190448..191908) FT /transl_table=11 FT /gene="murD" FT /locus_tag="Mb2179c" FT /product="UDP-N-acetylmuramoylalanine-D-glutamate ligase FT MurD" FT /EC_number="6.3.2.9" FT /note="Mb2179c, -, len: 486 aa. Equivalent to Rv2155c, len: FT 486 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 486 aa overlap). Probable murD, FT UDP-N-acetylmuramoylalanine-D-glutamate ligase (EC FT 6.3.2.9). FASTA best: MURD_BACSU Q03522 (451 aa) opt: 534, FT E(): 2.7e-25; (28.8% identity in 483 aa overlap); contains FT PS01011 Folylpolyglutamate synthase signature 1" FT /db_xref="GOA:Q7VEP7" FT /db_xref="HSSP:1E0D" FT /db_xref="InterPro:IPR005762" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEP7" FT /protein_id="CAD97032.1" FT /translation="MLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLR FT PHAERGLPTVSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLD FT AAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELL FT AVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDS FT RAAALLDGSPAQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGV FT LDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARA FT SVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVV FT QVVAGEDTGMPATVEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLA FT PAGASFDQFTGYADRGEAFATAVRAVIR" FT CDS complement(191910..192989) FT /transl_table=11 FT /gene="murX" FT /locus_tag="Mb2180c" FT /product="phospho-N-acetylmuramoyl-pentappeptidetransferase FT MurX" FT /EC_number="2.7.8.13" FT /note="Mb2180c, murX, len: 359 aa. Equivalent to Rv2156c, FT len: 359 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 359 aa overlap). Probable murX, FT phospho-N-acetylmuramoyl-pentappeptidetransferase (EC 2.7.8 FT .13). FASTA best: MRAY_ECOLI P15876 (360 aa) opt: 572 z-sco FT re: 651.6 E(): 2.7e-29; (35.8% identity in 344 aa overlap)" FT /db_xref="GOA:P64260" FT /db_xref="InterPro:IPR018480" FT /db_xref="UniProtKB/Swiss-Prot:P64260" FT /protein_id="CAD97033.1" FT /translation="MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHT FT KRGTPSMGGVAILAGIWAGYLGAHLAGLAFDGEGIGASGLLVLGLATALGGVGFIDDLI FT KIRRSRNLGLNKTAKTVGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVTLAP FT VLFVLFCVVIVSAWSNAVNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGC FT YNVRDPLDLALIAAATAGACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEIL FT AVVLGALFVAEITSVVLQILTFRTTGRRMFRMAPFHHHFELVGWAETTVIIRFWLLTAI FT TCGLGVALFYGEWLAAVGA" FT CDS complement(192986..194518) FT /transl_table=11 FT /gene="murF" FT /locus_tag="Mb2181c" FT /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamino FT pimelate-D-alanyl-D-alanyl ligase MurF" FT /note="Mb2181c, murF, len: 510 aa. Equivalent to Rv2157c, FT len: 510 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 510 aa overlap). Probable murF, FT UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D FT -alanyl-D-alanyl ligase (EC 6.3.2.15) FT (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE) also related to other FT Mycobacterium tuberculosis mur gene products. FASTA best: FT MURF_ECOLI P11880 (452 aa) opt: 515, E(): 2.6e-24, (31.9% FT identity in 511 aa overlap)" FT /note="deleted EC number 6.3.2.15" FT /db_xref="GOA:P0A5L5" FT /db_xref="HSSP:1GG4" FT /db_xref="InterPro:IPR005863" FT /db_xref="UniProtKB/Swiss-Prot:P0A5L5" FT /protein_id="CAD97034.1" FT /translation="MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIGPGG FT LFLALPGARADGHDHAASAVAAGAAVVLAARPVGVPAIVVPPVAAPNVLAGVLEHDNDG FT SGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPLGEVVAPPGS FT FNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAPPSIGVVLNVGTAHLGEFG FT SREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVWAGPVS FT LDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPP FT VSRHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAHQPEATRRSWAVLGEMAEL FT GEDAIAEHDRIGRLAVRLDVSRLVVVGTGRSISAMHHGAVLEGAWGSGEATADHGADRT FT AVNVADGDAALALLRAELRPGDVVLVKASNAAGLGAVADALVADDTCGSVRP" FT CDS complement(194515..196122) FT /transl_table=11 FT /gene="murE" FT /locus_tag="Mb2182c" FT /product="Probable FT UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate FT ligase MurE" FT /EC_number="6.3.2.13" FT /note="Mb2182c, murE, len: 535 aa. Equivalent to Rv2158c, FT len: 535 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 535 aa overlap). Probable murE, FT UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate FT ligase (EC 6.3.2.13; UDP-N-ACETYLMURAMYL-TRIPEPTIDE FT SYNTHETASE) also related to other Mycobacterium FT tuberculosis mur gene products. FASTA best: MURE_BACSU FT Q03523 (494 aa) opt: 1020 z- score: 1110.1 E(): 0; (40.1% FT identity in 476 aa overlap)" FT /db_xref="GOA:P65478" FT /db_xref="HSSP:1E8C" FT /db_xref="InterPro:IPR005761" FT /db_xref="UniProtKB/Swiss-Prot:P65478" FT /protein_id="CAD97035.1" FT /translation="MSSLARGISRRRTEVATQVEAAPTGLRPNAVVGVRLAALADQVGA FT ALAEGPAQRAVTEDRTVTGVTLRAQDVSPGDLFAALTGSTTHGARHVGDAIARGAVAVL FT TDPAGVAEIAGRAAVPVLVHPAPRGVLGGLAATVYGHPSERLTVIGITGTSGKTTTTYL FT VEAGLRAAGRVAGLIGTIGIRVGGADLPSALTTPEAPTLQAMLAAMVERGVDTVVMEVS FT SHALALGRVDGTRFAVGAFTNLSRDHLDFHPSMADYFEAKASLFDPDSALRARTAVVCI FT DDDAGRAMAARAADAITVSAADRPAHWRATDVAPTDAGGQQFTAIDPAGVGHHIGIRLP FT GRYNVANCLVALAILDTVGVSPEQAVPGLREIRVPGRLEQIDRGQGFLALVDYAHKPEA FT LRSVLTTLAHPDRRLAVVFGAGGDRDPGKRAPMGRIAAQLADLVVVTDDNPRDEDPTAI FT RREILAGAAEVGGDAQVVEIADRRDAIRHAVAWARPGDVVLIAGKGHETGQRGGGRVRP FT FDDRVELAAALEALERRA" FT CDS complement(196145..197179) FT /transl_table=11 FT /gene="Mb2183c" FT /locus_tag="Mb2183c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2183c, -, len: 344 aa. Equivalent to Rv2159c, len: FT 344 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 344 aa overlap). Conserved hypothetical FT protein; some similarity to hypothetical protein from FT Streptomyces coelicolor SC1A6.09c (337 aa, 29% identity). FT Smith-Waterman scores: >pir||T28690 hypothetical protein - FT Streptomyces coelicolor >gi|3127841|emb|CAA18907.1| FT (AL023496) Expect = 2e-18" FT /db_xref="InterPro:IPR003779" FT /db_xref="UniProtKB/TrEMBL:Q7TYZ4" FT /protein_id="CAD97036.1" FT /translation="MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDEG FT LLTAGWATLRETLLVGQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAAAI FT LAGTAPAAGDPNAPYVAWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLVLLD FT ETFLPGGPRAQQLMRRAGGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSEPIAT FT AFAALSHHLDTAPHLPPPTRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLHAPTRL FT ALLTGLAPHQVTDDDVAAARSLLDTDAALVGALAWAAFTAARRIGTWIGAAAEGQVSRQ FT NPTG" FT CDS complement(197176..197796) FT /transl_table=11 FT /gene="Mb2184c" FT /locus_tag="Mb2184c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2184c, -, len: 206 aa. Similar to 5' end of FT Rv2160A and 3' end of Rv2160c, len: 211 aa and 112 aa, from FT Mycobacterium tuberculosis strain H37Rv, (96.3% identity in FT 107 aa overlap and 92.0% identity in 112 aa overlap). FT Conserved hypothetical protein, possibly a tetR-family FT transcriptional regulator, similar to N-terminal half of FT AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 FT aa), FASTA scores: opt: 285, E(): 1.4e-08, (51.042% FT identity in 96 aa overlap). Next gene, Rv2160c, is similar FT to C-terminal half of 2SCK31.01c suggesting possible FT frameshift near 2421978 but sequence of this region has FT been checked and is also identical in strain CDC1551. FT Conserved hypothetical protein, possibly a tetR-family FT transcriptional regulator, similar to C-terminal half of FT AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY FT TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 FT aa), while Rv2160A is similar to the N-terminal half of FT 2SCK31.01c. This suggests possible frameshift near 2421978 FT but sequence of this region has been checked and is also FT identical in strain CDC1551. REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium tuberculosis strain H37Rv, Rv2160A and FT Rv2160c exist as 2 genes with an overlap region between FT them. In Mycobacterium bovis, a 4 bp insertion (*-ggaa) FT leads to a single product." FT /db_xref="GOA:Q7TYZ3" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7TYZ3" FT /protein_id="CAD97037.1" FT /translation="MPSADVGRQTRAQILRAAMDIASVKGLSGLSIGELAGRLGMSKSG FT LFRHFGAKEQLQLATVEAAVSVFEAEVVAPAMAAPPGVDRVRALMHAWVGYLERDVFPG FT GCFFAAAAADVDSQPGPVRDRIAATGRAGIAAITADVETAQRRGEIRADIEARQLAFEL FT HAYAMEANWALLLLDDDGAGERARTAIDAALARVGTTQEGVES" FT CDS complement(197789..198655) FT /transl_table=11 FT /gene="Mb2185c" FT /locus_tag="Mb2185c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2185c, -, len: 288 aa. Equivalent to Rv2161c, len: FT 288 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 288 aa overlap). Conserved hypothetical FT protein; shows some similarity to protein involved in FT lincomycin production and to other M. tuberculosis proteins FT e.g. Rv0953c, Rv0791c, Rv0132c, Rv2951c, Rv1855c. FASTA FT best: Q54379 (78-11) LINCOMYCIN PRODUCTION GENES (295 aa) FT opt: 243, E(): 2.4e-09; (29.5% identity in 285 aa FT overlap)." FT /db_xref="GOA:Q7TYZ2" FT /db_xref="InterPro:IPR019921" FT /db_xref="UniProtKB/TrEMBL:Q7TYZ2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97038.1" FT /translation="MLVSLMQFVTDLTPPPQLVAVWAEERGFAGLYVPEKTHVPISRST FT PWPGGELPDWYRRCYDPVVALAAAAAVTTRLRVGTGACLVAVHDPILLAKQIASLCAMS FT GERFVLGVGFGWNVEELADHGVPFADRIAVTVDKLAAMRALWAAEPVHYEGTHASVPPS FT WAWPKPAVAPPVLFGCRPSARAFEVIARHGDGWQPIEGYGELLGALPMLHAAFERAGRD FT PATAQVCVYSSAGDPATLHEYRRAGVAEVALALPSAGRDQVLAALDRSAPLVDAFAGDD FT REVKSHA" FT CDS complement(198758..200230) FT /transl_table=11 FT /gene="PE_PGRS38" FT /locus_tag="Mb2186c" FT /product="conserved hypothetical protein, PE_PGRS" FT /note="Mb2186c, PE_PGRS38, len: 490 aa. Similar to Rv2162c, FT len: 532 aa, from Mycobacterium tuberculosis strain H37Rv, FT (92.105% identity in 532 aa overlap). Member of FT Mycobacterium tuberculosis PE_PGRS family. FASTA score: FT Y03A_MYCTU Q 10637 hypothetical glycine-rich 49.6 kd FT protein (603 aa) op t: 1798 z-score: 1220.0 E(): 0; (55.4% FT identity in 590 aa overlap). REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium bovis, in-frame deletions of 108 bp and 18 FT bp leads to a shorter product than in Mycobacterium FT tuberculosis strain H37Rv (490 aa versus 532 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7VEP6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97039.1" FT /translation="MSFVIAAPEVMAAAATDLANIGSSISAASAAAAGPTMGILAAGAD FT EVSVAISALFGSHAQGYQTLSAQLAAYHNQFVRALNAGAGSYASAEAANVQQTLLNAIN FT APTQTLLGRPLIGNGADGGPGQNGGPGGLLYGNGGNGGAGDTANPNGGNGGSAGLIGNG FT GAGGAGAATGAGGAGGNGGWLYGNGGPGGAAGLGTAGGVSPAGGAGGAAGLWGHGGAGG FT AGGSASGAPGAGGAGGDGGRGGLLYGDGGAGGAGGNGSNGVTGVHGGNGGAGGAAGLIG FT NGGAGGDGGNGGLSNTGASGGAGGAGGAALIGNGGDGGHGGNGGHGNSGGAGGAGGAGG FT HVGLIGNGGNGGAGGNGGNDNSSTLADAGSGGAGAAGGNGGLFYGNGGVGGRGGNGGQA FT PTPGNAGDGGAGGNARLIGDGGRGGNGGEGGDGPPGVKGDGGNGGNGGNAVVIGNGGNG FT GAGGFGIPVGSGGAGGSRGVLFGTPGANGADG" FT CDS complement(200440..202479) FT /transl_table=11 FT /gene="pbpB" FT /locus_tag="Mb2187c" FT /product="Probable penicillin-binding membrane protein FT pbpB" FT /note="Mb2187c, pbpB, len: 679 aa. Equivalent to Rv2163c, FT len: 679 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 679 aa overlap). Probable pbpB, FT penicillin-binding membrane protein, similar to many FT bacterial PBP2 proteins e.g. FT P11882|PBP2_NEIME|PENA|NMA2072|NMB0413 penicillin-binding FT protein 2 (pbp-2) from Neisseria meningitidis (serogroups A FT and B) (581 aa), FASTA scores: opt: 665, E(): 1.6e-31, FT (33.2% identity in 591 aa overlap); etc. Also similar to FT Rv0016c and Rv2864c from Mycobacterium tuberculosis FT (2.8e-10). Contains PS00017 possible ATP/GTP-binding site FT motif A (P-loop) near C-terminus. FASTA best: PBP2_NEIME FT P11882 penicillin-binding protein 2 (pbp-2). (581 aa) opt: FT 665, E(): 1.6e-31; (33 .2% identity in 591 aa overlap)" FT /db_xref="GOA:Q7VEP5" FT /db_xref="HSSP:1PYY" FT /db_xref="InterPro:IPR005311" FT /db_xref="UniProtKB/TrEMBL:Q7VEP5" FT /protein_id="CAD97040.1" FT /translation="MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQA FT QEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVAAT FT QLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKRIR FT RQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDP FT AVASAICAKYPEVGAERQDLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDG FT SVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSGAHNVSA FT VVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEH FT GLSSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERY FT YDMLRKFGLGQRTGVGLPGESAGLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAI FT ANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVRQMLRAVVQRDPMGYQQ FT GTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNP FT ARNSDGAPGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT" FT CDS complement(202476..203630) FT /transl_table=11 FT /gene="Mb2188c" FT /locus_tag="Mb2188c" FT /product="PROBABLE CONSERVED PROLINE RICH MEMBRANE PROTEIN" FT /note="Mb2188c, -, len: 384 aa. Equivalent to Rv2164c, len: FT 384 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 384 aa overlap). Probable pro- rich FT conserved membrane protein, equivalent to ML0907|AL022602 FT putative conserved membrane protein from Mycobacterium FT leprae (377 aa) (AL022602), FASTA scores: opt: 1495, E(): FT 1.7e-56, (62.217% identity in 397 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TYZ1" FT /protein_id="CAD97041.1" FT /translation="MRAKREAPKSRSSDRRRRADSPAAATRRTTTNSAPSRRIRSRAGK FT TSAPGRQARVSRPGPQTSPMLSPFDRPAPAKNTSQAKARAKARKAKAPKLVRPTPMERL FT AARLTSIDLRPRTLANKVPFVVLVIGSLGVGLGLTLWLSTDAAERSYQLSNARERTRML FT QQHKEALERDVREAASAPALAEAARRQGMIPTRDTAHLAQDPDGNWVVVGTPKPADGVP FT PPPLNTKLPEDPPPPPKPAAVPLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGTATLGG FT ATHLPTQAGPQLPGPVPIPGAPGPMPAPPLGAVPSPAPAENPVPLQVGAAPPAGLPGPA FT PVAATPGLSGGSQPMVAPPAPVPANGEQFGPVTAPVPTAPGAPR" FT CDS complement(203627..204817) FT /transl_table=11 FT /gene="Mb2189c" FT /locus_tag="Mb2189c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2189c, -, len: 396 aa. Equivalent to Rv2165c, len: FT 396 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 396 aa overlap). Conserved hypothetical FT protein; shows strong similarity to several hypothetical FT bacterial proteins but has extra 80 aa residues at FT N-terminus FASTA best: YLXA_BACSU Q07876 hypothetical 35.3 FT kd protein in ftsl (311 aa) opt: 781, E(): 0; (45.6% FT identity in 296 aa overlap), BELONGS TO THE YABC (E.COLI), FT YLXA (B.SUBTILIS) FAMILY" FT /db_xref="GOA:P65430" FT /db_xref="HSSP:1M6Y" FT /db_xref="InterPro:IPR002903" FT /db_xref="UniProtKB/Swiss-Prot:P65430" FT /protein_id="CAD97042.1" FT /translation="MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTAC FT QTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHA FT ERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVG FT SVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADIL FT RRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALR FT IAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVE FT LPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS" FT CDS complement(204819..205250) FT /transl_table=11 FT /gene="Mb2190c" FT /locus_tag="Mb2190c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2190c, -, len: 143 aa. Equivalent to Rv2166c, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 143 aa overlap). Conserved hypothetical FT protein; shows strong similarity to several hypothetical FT bacterial proteins such as YLLB_BACSU P55343. Is equivalent FT to Mycobacterium leprae hypothetical protein ML0905 (143 FT aa, 92% identity) MLCB268.11c >sp|O69561|YL66_MYCLE FT HYPOTHETICAL 16.1 KDA PROTEIN ML0905 FT >gi|3080482|emb|CAA18677.1|(AL022602) FT >gi|13092975|emb|CAC31286.1|(AL583920). FASTA scores: FT ML0905|ML0905 conserved hypothetical protein (143 aa) opt: FT 873, E(): 3.1e-52; 92.254% identity in 142 aa overlap; FT YLLB_BACSU P55343 hypothetical 16.6 kd protein (143 aa) FT opt: 340, E(): 3.6e-17; (35.0% identity in 143 aa overlap). FT BELONGS TO THE YABB (E.COLI), YLLB (B.SUBTILIS), MG221 ( FT M.GENITALIUM) FAMILY" FT /db_xref="InterPro:IPR003444" FT /db_xref="UniProtKB/Swiss-Prot:P65437" FT /protein_id="CAD97043.1" FT /translation="MFLGTYTPKLDDKGRLTLPAKFRDALAGGLMVTKSQDHSLAVYPR FT AAFEQLARRASKAPRSNPEARAFLRNLAAGTDEQHPDSQGRITLSADHRRYASLSKDCV FT VIGAVDYLEIWDAQAWQNYQQIHEENFSAASDEALGDIF" FT CDS complement(205599..206003) FT /transl_table=11 FT /gene="Mb2191c" FT /locus_tag="Mb2191c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb2191c, -, len: 134 aa. Equivalent to Rv2169c, len: FT 134 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 134 aa overlap). Probable conserved FT transmembrane protein, with orthologs in M. leprae, ML0904 FT probable membrane protein (134 aa), and Streptomyces FT coelicolor. FASTA scores with ML0904, opt: 767, E(): FT 5.1e-43; 86.567% identity in 134 aa overlap. FT emb|CAA18678.1| (AL022602) >gi|13092974|emb|CAC31285.1| FT (AL583920). TBparse score is 0.934" FT /db_xref="GOA:Q7TYZ0" FT /db_xref="UniProtKB/TrEMBL:Q7TYZ0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97044.1" FT /translation="MPLSDHEQRMLDQIESALYAEDPKFASSVRGGGFRAPTARRRLQG FT AALFIIGLGMLVSGVAFKETMIGSFPILSVFGFVVMFGGVVYAITGPRLSGRMDRGGSA FT AGASRQRRTKGAGGSFTSRMEDRFRRRFDE" FT CDS 206269..206889 FT /transl_table=11 FT /gene="Mb2192" FT /locus_tag="Mb2192" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2192, -, len: 206 aa. Equivalent to Rv2170, len: FT 206 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 206 aa overlap). Conserved hypothetical FT protein, equivalent to hypothetical protein ML0903 (210 aa) FT from Mycobacterium leprae. FASTA scores: ML0903 conserved FT hypothetical protein (210 aa) opt: 1045, E(): 9.1e-57; FT 77.143% identity in 210 aa overlap. >emb|CAA18679.1| FT (AL022602) >gi|13092973|emb|CAC31284.1| (AL583920)." FT /db_xref="GOA:Q7TYY9" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q7TYY9" FT /protein_id="CAD97045.1" FT /translation="MAIFLIDLPPSDMERRLGDALTVYVDAMRYPRGTETLRAPMWLEH FT IRRRGWQAVAAVEVTAAEQAEAADTTALPSAAELSNAPMLGVAYGYPGAPGQWWQQQVV FT LGLQRSGFPRLAIARLMTSYFELTELHILPRAQGRGLGEALARRLLAGRDEDNVLLSTP FT ETNGEDNRAWRLYRRLGFTDIIRGYHFAGDPRAFAILGRTLPL" FT CDS 206985..207668 FT /transl_table=11 FT /gene="lppM" FT /locus_tag="Mb2193" FT /product="Probable conserved lipoprotein lppM" FT /note="Mb2193, lppM, len: 227 aa. Equivalent to Rv2171, FT len: 227 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 227 aa overlap). Probable lppM, FT conserved lipoprotein; contains putative signal peptide and FT appropriately positioned PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. Has hydrophobic stretch FT at C-terminus and also contains PS00225 Crystallins beta FT and gamma 'Greek key' motif signature. Unknown but FT equivalent to Mycobacterium leprae lipoprotein ML0902 (239 FT aa). FASTA scores: opt: 1083, E(): 2.4e-56; 75.446% FT identity in 224 aa overlap (5-227:16-239) >emb|CAA18680.1| FT (AL022602) >gi|13092972|emb|CAC31283.1| (AL583920)." FT /db_xref="UniProtKB/TrEMBL:Q7VEP4" FT /protein_id="CAD97046.1" FT /translation="MARTRRRGMLAIAMLLMLVPLATGCLRVRASITISPDDLVSGEII FT AAAKPKNSKDTGPALDGDVPFSQKVAVSNYDSDGYVGSQAVFSDLTFAELPQLANMNSD FT AAGVNLSLRRNGNIVILEGRADLTSVSDPDADVELTVAFPAAVTSTNGDRIEPEVVQWK FT LKPGVVSTMSAQARYTDPNTRSFTGAGIWLGIAAFAAAGVVAVLAWIDRDRSPRLTASG FT DPPTS" FT CDS complement(207665..208570) FT /transl_table=11 FT /gene="Mb2194c" FT /locus_tag="Mb2194c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2194c, -, len: 301 aa. Equivalent to Rv2172c, len: FT 301 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 301 aa overlap). Conserved hypothetical FT protein, equivalent to Mycobacterium leprae conserved FT hypothetical protein ML0901 (304 aa). FASTA scores: opt: FT 1656, E(): 7.7e-98; 81.271% identity in 299 aa overlap FT (1-299:1-299) FT CAA18681.1|AL022602|13092971|CAC31282.1|AL583920. TBparse FT score is 0.905" FT /db_xref="UniProtKB/TrEMBL:Q7TYY8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97047.1" FT /translation="MTLNTIALELVPPNLEGGKERAIEDARKVVQYSAASGLDGRIRHV FT MMPGMIAEDDDRPIPMQPKLDVLDFWSIIKPELAGVHGLCTQVTAFMDEPSLHRRLVDL FT SDAGMEGIVFVGVPRTMQDGEGSGVAPTDALSLYRQLVANRGVIVIPTRDGEQGRLNFK FT CSRGATYGMTQLLYSDAIVGFLREFARTTEHRPEILLSFGFVPKVETRIGLINWLIQDP FT GNAAVADEQAFVQKLAGSEPARRRRLMVDLYKRVLDGVADLGFPLSIHLEATYGVSAAA FT FETFAEMLAYWSPAEPGKPD" FT CDS 208881..209939 FT /transl_table=11 FT /gene="idsA2" FT /locus_tag="Mb2195" FT /product="PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE FT IDSA2 (GGPPSASE) (GGPP SYNTHETASE) (GERANYLGERANYL FT DIPHOSPHATE SYNTHASE)" FT /EC_number="2.5.1.-" FT /note="Mb2195, idsA2, len: 352 aa. Equivalent to Rv2173, FT len: 352 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 352 aa overlap). Probable idsA2, FT geranylgeranyl pyrophosphate synthase (EC 2.5.1.-), similar FT to many e.g. Q54193 geranylgeranyl pyrophosphate synthase FT from Streptomyces griseus (425 aa). Contains PS00723 and FT PS00444Polyprenyl synthetases signature 1 and 2. FASTA FT scores: sptr|Q54193|Q54193 GERANYLGERANYL PYROPHOSPHATE FT SYNTHASE (425 aa) opt: 744, E(): 0; 39.2% identity in 352 FT aa overlap." FT /db_xref="GOA:Q7TYY7" FT /db_xref="InterPro:IPR000092" FT /db_xref="UniProtKB/TrEMBL:Q7TYY7" FT /protein_id="CAD97048.1" FT /translation="MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRL FT RPLFAYWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQLRYA FT ALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPDAQRRVHRVWADIR FT NEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFE FT HFGADLGVAFQLRDDVLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAK FT LLRTSIGTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGL FT SELAMMAANRSA" FT CDS 209943..211493 FT /transl_table=11 FT /gene="Mb2196" FT /locus_tag="Mb2196" FT /product="Possible conserved integral membrane protein" FT /note="Mb2196, -, len: 516 aa. Equivalent to Rv2174, len: FT 516 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 516 aa overlap). Possible conserved FT integral membrane protein, similar to some hypothetical FT mycobacterial proteins e.g. Mycobacterium leprae ML0899 FT probable integral-membrane protein (505 aa) and MLCL536_26 FT (593 aa). FASTA scores: ML0899 opt: 2715; 78.884% identity FT in 502 aa overlap and gp|Z99125|MLCL536_26 Mycobacterium FT leprae cosmid L536. (593 aa) opt: 552, E(): 7.1e-30; 31.6% FT identity in 513 aa overlap. Also similar to Rv1459c." FT /db_xref="InterPro:IPR017822" FT /db_xref="UniProtKB/TrEMBL:Q7VEP3" FT /protein_id="CAD97049.1" FT /translation="MTTPSHAPAVDLATAKDAVVQHLSRLFEFTTGPQGGPARLGFAGA FT VLITAGGLGAGSVRQHDPLLESIHMSWLRFGHGLVLSSILLWTGVGVMLLAWLGLGRRV FT LAGEATEFTMRATTVIWLAPLLLSVPVFSRDTYSYLAQGALLRDGLDPYAVGPVGNPNA FT LLDDVSPIWTITTAPYGPAFILVAKFVTVIVGNNVVAGTMLLRLCMLPGLALLVWATPR FT LASHLGTHGPTALWICVLNPLVLIHLMGGVHNEMLMVGLMTAGIALTVQGRNVAGIILI FT TVAIAVKATAGIALPFLVWVWLRHLRERRGYRPVQAFLAAAAISLLIFVAVFAVLSAVA FT GVGLGWLTALAGSVKIINWLTVPTGAANVIHALGRGLFTVDFYTLLRITRLIGIVIIAV FT SLPLLWWRFRRDDRAALTGVAWSMLIVVLFVPAALPWYYSWPLAVAAPLAQSRRAIAAI FT AGLSTWVMVIFKPDGSHGMYSWLHFWIATACALTAWYVLYRSPDRRGVQAATPVVNTP" FT CDS complement(211480..211920) FT /transl_table=11 FT /gene="Mb2197c" FT /locus_tag="Mb2197c" FT /product="conserved hypothetical regulatory protein" FT /note="Mb2197c, -, len: 146 aa. Equivalent to Rv2175c, len: FT 146 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 146 aa overlap). Conserved hypothetical FT protein, possibly involved in regulation. Contains possible FT helix-turn-helix domain at aa 31-52 (Score 1042, +2.74 SD). FT Equivalent to Mycobacterium leprae ML0898 putative FT DNA-binding protein (134 aa). FASTA scores: opt: 747; FT 82.090% identity in 134 aa overlap (AL022602) FT >gi|13092969|emb|CAC31279.1| (AL583920)" FT /db_xref="UniProtKB/TrEMBL:Q7VEP2" FT /protein_id="CAD97050.1" FT /translation="MPGRAPGSTLARVGSILAGDDVLDPDEPTYDLPRVAELLGVPVSK FT VAQQLREGHLVAVRRAGGVVIPQVFFTNSGQVVKSLPGLLTILHDGGYRDTEIMRWLFT FT PDPSLTITRDGSRDAVSNARPVDALHAHQAREVVRRAQAMAY" FT CDS 211975..213174 FT /transl_table=11 FT /gene="pknL" FT /locus_tag="Mb2198" FT /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN FT KINASE L PKNL (PROTEIN KINASE L) (STPK L)" FT /EC_number="2.7.1.-" FT /note="Mb2198, pknL, len: 399 aa. Equivalent to Rv2176, FT len: 399 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 399 aa overlap). Probable pknL, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-) FT (see citation below), similar to many e.g. MLCB1770_9 (622 FT aa). Lacks C-terminal domain and ends with putative FT transmembrane segment. Contains PS00108 Serine/Threonine FT protein kinases active-site signature. FASTA scores: FT Z70722|MLC B1770_9 Mycobacterium leprae cosmid B1770 (622 FT aa) opt: 732, E(): 5.9e-23; 44.4% identity in 266 aa FT overlap. Also similar to several Mycobacterium tuberculosis FT STPK proteins e.g. Rv0014c|PKNB, Rv0015c|PKNA, Rv1743|PKNE, FT Rv1266c|PKNH etc. Contains Hank's kinase subdomain. BELONGS FT TO THE SER/THR FAMILY OF PROTEIN KINASES." FT /db_xref="GOA:Q7TYY6" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:Q7TYY6" FT /protein_id="CAD97051.1" FT /translation="MVEAGTRDPLESALLDSRYLVQAKIASGGTSTVYRGLDVRLDRPV FT ALKVMDARYAGDEQFLTRFRLEARAVARLNNRALVAVYDQGKDGRHPFLVMELIEGGTL FT RELLIERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKLADFGL FT VRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPFTGDS FT ALSIAYQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLEAIAEE FT LALPEFRVPAPRNSAQHRSAALYRSRITQQGQLGAKPVHHPTRQLTRQPGDCSEPASGS FT EPEHEPITGQFAGIAIEEFIWARQHARRMVLVWVSVVLAITGLVASAAWTIGSNLSGLL FT " FT repeat_region complement(213179..213982) FT /mobile_element="insertion sequence:IS1558" FT /locus_tag="IS1558'-1" FT /note="IS1558'-1, len: 804 nt. Equivalent to IS1558', len: FT 804 nt, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 804 nt overlap). Nearly identical to FT complement of region 24105 24908 in EM_BA:MTCY428 Z81451 FT Mycobacterium tuberculosis cosmid Y428." FT CDS complement(213316..213981) FT /transl_table=11 FT /gene="Mb2199c" FT /locus_tag="Mb2199c" FT /product="POSSIBLE TRANSPOSASE" FT /note="Mb2199c, -, len: 221 aa. Equivalent to Rv2177c, len: FT 221 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 221 aa overlap). Possible IS1558 FT transposase (see citation below), similar to several IS FT element proteins and transposases but nearly identical to FT last 221 residues of MTCY428_23 (333 aa). FASTA scores: FT Z81451|MTCY428_23 Mycobacterium tuberculosis cosmid (333 FT aa) opt: 1491, E() : 0; 98.6% identity in 221 aa overlap." FT /db_xref="GOA:Q7TYY5" FT /db_xref="InterPro:IPR003346" FT /db_xref="UniProtKB/TrEMBL:Q7TYY5" FT /protein_id="CAD97052.1" FT /translation="MRSKIPDLQRALEGRFDDHHALMCRLHLAHLDQLDAMIGALDEQI FT EQLMHPFCARRELIASIPGIGVGASATVISEIGADPAAWFPSAEHLASWVRLCPGNHES FT AGKRHHGARRKGNQHLQPVLVECAWAAVRTDGYLREYYRRQVRKFGGFRSPAANKKAII FT AVAHKLIVIIWHVLATGRPYQDLGADYFTTRMDPDKERRRLVAKLEAQGLGVTLEPAA" FT CDS complement(214366..215754) FT /transl_table=11 FT /gene="aroG" FT /locus_tag="Mb2200c" FT /product="Probable 3-deoxy-D-arabino-heptulosonate FT 7-phosphate synthase AroG (DAHP synthetase, FT phenylalanine-repressible)" FT /EC_number="2.5.1.54" FT /note="Mb2200c, aroG, len: 462 aa. Equivalent to Rv2178c, FT len: 462 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 462 aa overlap). Probable aroG, FT 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase FT similar to many, especially those from plants. FASTA FT scores: Y15113|M C3DDAH7P_1Morinda citrifolia mRNA for FT 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (535 FT aa) opt: 1421, E(): 0; 48.3% identity in 443 aa overlap." FT /db_xref="GOA:Q7VEP1" FT /db_xref="InterPro:IPR002480" FT /db_xref="UniProtKB/TrEMBL:Q7VEP1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97053.1" FT /translation="MNWTVDIPIDQLPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQA FT LAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVR FT ALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAAARE FT HDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALATEID FT RGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGEDGEPQLFDLSAHTVWI FT GERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGN FT HKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHR FT ALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAE FT MLRD" FT CDS complement(215845..216351) FT /transl_table=11 FT /gene="Mb2201c" FT /locus_tag="Mb2201c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2201c, -, len: 168 aa. Equivalent to Rv2179c, len: FT 168 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 168 aa overlap). Conserved hypothetical FT protein, equivalent to conserved hypothetical protein from FT Mycobacterium leprae ML0895 conserved hypothetical protein FT (171 aa). FASTA scores: opt: 977, E(): 1.4e-58; 82.530% FT identity in 166 aa overlap (AL022602)." FT /db_xref="UniProtKB/TrEMBL:Q7TYY4" FT /protein_id="CAD97054.1" FT /translation="MRYFYDTEFIEDGHTIELISIGVVAEDGREYYAVSTEFDPERAGS FT WVRTHVLPKLPPPASQLWRSRQQIRLDLEEFLRIDGTDSIELWAWVGAYDHVALCQLWG FT PMTALPPTVPRFTRELRQLWEDRGCPRMPPRPRDVHDALVDARDQLRRFRLITSTDDAG FT RGAAR" FT CDS complement(216361..217248) FT /transl_table=11 FT /gene="Mb2202c" FT /locus_tag="Mb2202c" FT /product="Probable conserved integral membrane protein" FT /note="Mb2202c, -, len: 295 aa. Equivalent to Rv2180c, len: FT 295 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 295 aa overlap). Probable conserved FT integral membrane protein, similar to pir||T35292 probable FT integral membrane protein from Streptomyces coelicolor FT >gi|5578858|emb|CAB51260.1| (AL096872) (246 aa) (36% FT identity in 249 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7VEP0" FT /protein_id="CAD97055.1" FT /translation="MEVFHWLQHDIVDRGRLPLLCCLVAFVLTFLVTRSFVRFIHRRAA FT DGRPARWWQPRNVHIGSVHIHHVAFGVVLVMISGLTLVTLSVDGREPEFTIAASIFGVG FT AALVLDEYALILHLSDVYWEEDGRTSVDAVFAAVAVAGLLIMGLHPLIFFLTVRQGANW FT VVLQTTLIAGLVLTLPLAVVVLLKGKVWTGLLGMFVVVLLVVGAVRLSRPHAPWARWRY FT TRHPEKMRRALQRERTWRRPVVRIKLWLQYVIAGTPRMPDERAVDAQLDQDVRPAPPPE FT RTAPILISGSVWSD" FT CDS 217336..218619 FT /transl_table=11 FT /gene="Mb2203" FT /locus_tag="Mb2203" FT /product="Probable conserved integral membrane protein" FT /note="Mb2203, -, len: 427 aa. Equivalent to Rv2181, len: FT 427 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 427 aa overlap). Probable conserved FT integral membrane protein, similar to others in FT Mycobacterium tuberculosis e.g. Rv1159 (MTCI65.26, 431 aa). FT Start uncertain. FASTA scores: Z95584|MTCI65_26 (431 aa) FT opt: 428, E(): 8e-22; 31.2% identity in 407 aa overlap." FT /db_xref="InterPro:IPR018584" FT /db_xref="UniProtKB/TrEMBL:Q7VEN9" FT /protein_id="CAD97056.1" FT /translation="MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRI FT DIDIYQMGARAWLDGRPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPAASVA FT ITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPISSNF FT AFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTA FT LASFAVATLLGFVLAWRDSWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERF FT ALWVAGSLLVLAATIWAMRRVLRAGEPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLV FT IGLLGWRRRNVALAMLSLAGVVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVI FT VVAGLTVTARMTPQRSLTRGLTPAPTAS" FT CDS complement(218620..219363) FT /transl_table=11 FT /gene="Mb2204c" FT /locus_tag="Mb2204c" FT /product="1-acylglycerol-3-phosphate O-acyltransferase" FT /EC_number="2.3.1.51" FT /note="Mb2204c, -, len: 247 aa. Equivalent to Rv2182c, len: FT 247 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 247 aa overlap). Probable FT 1-acylglycerol-3-phosphate O-acyltransferase, similar to FT many e.g. in Streptomyces. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop). FASTA scores: pir||T35503 FT 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) FT homolog SC6E10.16c - Streptomyces coelicolor FT >gi|5689932|emb|CAB51970.1| (AL109661) hypothetical protein FT [Streptomyces coelicolor A3(2)] Length = 262, Expect = FT 6e-61 (54% identity in 215 aa overlap)." FT /db_xref="GOA:Q7VEN8" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/TrEMBL:Q7VEN8" FT /protein_id="CAD97057.1" FT /translation="MWYYLFKYIFMGPLFTLLGRPKVEGLEYIPSSGPAILASNHLAVA FT DSFYLPLVVRRRIWFLAKSEYFTGTGLKGWINRWFYSVSGQVPIDRTNADSAQGALQTA FT VVLLGQGKLLGMYPEGTRSPDGRLYKGKTGLARLALHTGVPVIPVAMIGTNVVNPPGRK FT MLRFGRVTVRFGKPMDFSRFEGLAGNHFIERAVTDEVIYELMGLSGQEYVDIYAASVKD FT GRNAGGAGANPNSTDAARIPETAAG" FT CDS complement(219449..219844) FT /transl_table=11 FT /gene="Mb2205c" FT /locus_tag="Mb2205c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2205c, -, len: 131 aa. Equivalent to Rv2183c, len: FT 131 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 131 aa overlap). Conserved hypothetical FT protein, equivalent to Mycobacterium leprae hypothetical FT protein ML0891 (MLCB268.25c, 130 aa). FASTA scores: opt: FT 558, E(): 8.3e-28; 61.832% identity in 131 aa overlap FT >gi|13092963|emb|CAC31272.1| (AL583920) (AL022602)." FT /db_xref="UniProtKB/TrEMBL:Q7TYY3" FT /protein_id="CAD97058.1" FT /translation="MSGAHTDVRPELRKLAQAILDGIDPAVRVAAAMASGGGPGTGKCQ FT QVWCPLCALAALVTGEQHPLLTVIADHSLALLEVIRAIVDDIDRSAKPPPEGPPGGGQT FT GASGGENTNGEGSMKSHYQAIPVTIEE" FT CDS complement(219841..220980) FT /transl_table=11 FT /gene="Mb2206c" FT /locus_tag="Mb2206c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2206c, -, len: 379 aa. Equivalent to Rv2184c, len: FT 379 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 379 aa overlap). Conserved hypothetical FT protein, equivalent to hypothetical protein ML0890 (415 aa) FT from Mycobacterium leprae and also shows some similarity to FT other hypothetical proteins. FASTA scores: ML0890 opt: FT 1949; 79.630% identity in 378 aa overlap >emb|CAA18692.1| FT (AL022602) >gi|13092962|emb|CAC31271.1| (AL583920) and FT sptr|Q55794|Q55794 HYPOTHETICAL 44.6 KD PROTEIN. (396 aa) FT opt: 251, E(): 3.3e-09; 25.5% identity in 384 aa overlap." FT /db_xref="GOA:Q7TYY2" FT /db_xref="InterPro:IPR003348" FT /db_xref="UniProtKB/TrEMBL:Q7TYY2" FT /protein_id="CAD97059.1" FT /translation="MVVSTDQAHSLGDVLGIAVPPTGQGDPVRVLAYDPEAGGGFLDAL FT ALDTLALLEGRWLHVVETLDRRFPGSELSSIAPEELCALPGIQEVLGLHAVGELAAARR FT WDRIVVDCASTADALRMLTLPATFGLYVERAWPRHRRLSIGADDGRSAVLAELLERIRA FT SVERLSTLLTDGALVSAHLVLTPERVVAAEAVRTLGSLALMGVRVEELLVNQLLVQDEN FT YEYRSLPDHPAFHWYAERIGEQRAVLDDLDATIGDVALVLVPHLAGEPIGPKALGGLLD FT SARRRQGSAPPGPLQPIVDLESGSGLASIYRLRLALPQLDPGTLTLGRADDDLIVSAGG FT MRRRVRLASVLRRCTVLDAHLRGGELTVRFRPNPEVWPT" FT CDS complement(221100..221534) FT /transl_table=11 FT /gene="TB16.3" FT /locus_tag="Mb2207c" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB16.3" FT /note="Mb2207c, TB16.3, len: 144 aa. Equivalent to Rv2185c, FT len: 144 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 144 aa overlap). TB16.3, conserved FT hypothetical protein, similar to other hypothetical FT actinomycete proteins and equivalent to Mycobacterium FT leprae ML0889 (144 aa). Some similarity to Mycobacterium FT tuberculosis Rv0854, Rv0856, Rv0857, Rv0164 and other FT Mycobacterium leprae proteins. FASTA scores : ML0889 opt: FT 811; 85.417% identity in 144 aa overlap (AL022602)." FT /db_xref="InterPro:IPR005031" FT /db_xref="UniProtKB/TrEMBL:Q7TYY1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97060.1" FT /translation="MADKTTQTIYIDADPGEVMKAIADIEAYPQWISEYKEVEILEADD FT EGYPKRARMLMDAAIFKDTLIMSYEWPEDRQSLSWTLESSSLLKSLEGTYRLAPKGSGT FT EVTYELAVDLAVPMIGMLKRKAERRLIDGALKDLKKRVEG" FT CDS complement(221639..222028) FT /transl_table=11 FT /gene="Mb2208c" FT /locus_tag="Mb2208c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2208c, -, len: 129 aa. Equivalent to Rv2186c, len: FT 129 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 129 aa overlap). Conserved hypothetical FT protein, equivalent to hypothetical Mycobacterium leprae FT protein ML0888 (135 aa). FASTA scores: ML0888 opt: 704, FT E(): 2.9e-43; 80.000% identity in 130 aa overlap FT CAA18694.1| (AL022602)." FT /db_xref="UniProtKB/TrEMBL:Q7TYY0" FT /protein_id="CAD97061.1" FT /translation="MNSIQIADETYVAADAARVSAAVADRCSWRRWWPDLRLQVTEDRA FT DKGIRWTVTGALTGTMEIWLEPSMDGVLLHYFLHAEPTGVAAWQLARMNLARMTHHRRV FT AGKKMAFEVKTVLERSRPIGVSPVT" FT CDS 222194..222706 FT /transl_table=11 FT /gene="Mb2209" FT /locus_tag="Mb2209" FT /product="HYPOTHETICAL PROTEIN" FT /EC_number="6.2.1.3" FT /note="Mb2209, -, len: 170 aa. Equivalent to 5' end of FT Rv2187, len: 600 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 90 aa overlap). Probable fadD15, FT long-chain-fatty-acid-CoA ligase (EC 6.2.1.3), similar to FT several e.g. P44446|LCFH_HAEIN PUTATIVE FT LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus FT influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E(): FT 0, (31.5% identity in 578 aa overlap); etc. Contains FT PS00455 Putative AMP-binding domain signature. BELONGS TO FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, fadD15 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to single base FT deletion (t-*) splits fadD15 into 2 parts, Mb2209 and FT fadD15." FT /db_xref="GOA:Q7TYX9" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TYX9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97062.1" FT /translation="MREISVPAPFTVGEHDNVAAMVFEHERDDPDYVIYQRLIDGVWTD FT VTCAEAANQIRAAALGLISLGVQAGDRVVIFSATRYEWAILDFAIRLWVRSPYRSTRPR FT QRSRCAGFYKTPKRWCCSPKPTHTRQWSPNSPAACPPCGRYCRSPVRVPTRSIGSRRRA FT PRSTRPS" FT CDS 222469..223995 FT /transl_table=11 FT /gene="fadD15" FT /locus_tag="Mb2210" FT /product="Probable long-chain-fatty-acid-CoA ligase fadD15 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /EC_number="6.2.1.3" FT /note="Mb2210, fadD15, len: 508 aa. Equivalent to 3' end of FT Rv2187, len: 600 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.6% identity in 508 aa overlap). Probable fadD15, FT long-chain-fatty-acid-CoA ligase (EC 6.2.1.3), similar to FT several e.g. P44446|LCFH_HAEIN PUTATIVE FT LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus FT influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E(): FT 0, (31.5% identity in 578 aa overlap); etc. Contains FT PS00455 Putative AMP-binding domain signature. BELONGS TO FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. TBparse score FT is 0.902. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a frameshift due to single base deletion (t-*) leads FT to a shorter product with a different NH2 part compared to FT its homolog in Mycobacterium tuberculosis strain H37Rv." FT /db_xref="GOA:Q7TYX8" FT /db_xref="HSSP:1BA3" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TYX8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97063.1" FT /translation="MGAVTVPIYETSSAEQVRWVLQDSEAVVLFAETDSHATMVAELSG FT SVPALREVLQIAGSGPNALDRLTEAGASVDPAELTARLAALRSTDPATLIYTSGTTGRP FT KGCQLTQSNLVHEIKGARAYHPTLLRKGERLLVFLPLAHVLARAISMAAFHSKVTVGFT FT SDIKNLLPMLAVFKPTVVVSVPRVFEKVYNTAEQNAANAGKGRIFAIAAQTAVDWSEAC FT DRGGPGLLLRAKHAVFDRLVYRKLRAALGGNCRAAVSGGAPLGARLGHFYRGAGLTIYE FT GYGLSETSGGVAISQFNDLKIGTVGKPVPGNSLRIADDGELLVRGGVVFSGYWRNEQAT FT TEAFTDGWFKTGDLGAVDEDGFLTITGRKKEIIVTAGGKNVAPAVLEDQLRAHPLISQA FT VVVGDAKPFIGALITIDPEAFEGWKQRNSKTAGASVGDLATDPDLIAEIDAAVKQANLA FT VSHAESIRKFRILPVDFTEDTGELTPTMKVKRKVVAEKFASDIEAIYNKE" FT CDS complement(224026..225183) FT /transl_table=11 FT /gene="Mb2211c" FT /locus_tag="Mb2211c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2211c, -, len: 385 aa. Equivalent to Rv2188c, len: FT 385 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 385 aa overlap). Conserved hypothetical FT protein, possibly glycosyl transferase similar to several FT putative glycosyl transferases and hypothetical proteins FT e.g. P73369. Equivalent to Mycobacterium leprae ML0886 FT putative glycosyl transferase (384 aa). FASTA scores: FT ML0886 (CAA18697.1| (AL022602) ) opt: 2113, E(): 1.8e-106; FT 81.462% identity in 383 aa overlap; sptr|P73369|P73369 FT HYPOTHETICAL 46.2 KD PROTEIN (404 aa) opt: 379, E(): FT 2.2e-18; 27.5% identity in 397 aa overlap. Start changed FT since first submission, now 14 aa shorter." FT /db_xref="GOA:Q7TYX7" FT /db_xref="InterPro:IPR001296" FT /db_xref="UniProtKB/TrEMBL:Q7TYX7" FT /protein_id="CAD97064.1" FT /translation="MSRVLLVTNDFPPRRGGIQSYLGEFVGRLVGSRAHAMTVYAPQWK FT GADAFDDAARAAGYRVVRHPSTVMLPGPTVDVRMRRLIAEHDIETVWFGAAAPLALLAP FT RARLAGASRVLASTHGHEVGWSMLPVARSVLRRIGDGTDVVTFVSSYTRSRFASAFGPA FT ASLEYLPPGVDTDRFRPDPAARAELRKRYRLGERPTVVCLSRLVPRKGQDTLVTALPSI FT RRRVDGAALVIVGGGPYLETLRKLAHDCGVADHVTFTGGVATDELPAHHALADVFAMPC FT RTRGAGMDVEGLGIVFLEASAAGVPVIAGNSGGAPETVQHNKTGLVVDGRSVDRVADAV FT AELLIDRDRAVAMGAAGREWVTAQWRWDTLAAKLADFLRGDDAAR" FT CDS complement(225280..226053) FT /transl_table=11 FT /gene="Mb2212c" FT /locus_tag="Mb2212c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2212c, -, len: 257 aa. Equivalent to Rv2189c, len: FT 257 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 257 aa overlap). Conserved hypothetical FT protein; some similarity to hypothetical protein SC6G10.07c FT (385 aa) from Streptomyces coelicolor A3(2). Smith-Waterman FT scores: pir||T35516 hypothetical protein SC6G10.07c - FT Streptomyces coelicolor >gi|4539203|emb|CAB39861.1| FT (AL049497) Expect = 2e-08; 30% identity in 245 aa overlap. FT TBparse score is 0.908" FT /db_xref="UniProtKB/TrEMBL:Q7TYX6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97065.1" FT /translation="MRDGPAAPAQVVAPADGFVALRVADDRTVRLLSLGGAATDRLLSR FT IAAGIDAAVDEVVAFWGTDWSHDIFVVAAGSDEQFHAAAGGGLASQWADIAAITVVDRV FT DPARRTVVGQRIVFAPGAAHMSPAALRIVLGHELFHYAARADTALDAPRWLAEGVADFV FT ARPKTPPPADAVSVALSLPSDTDLDTPGPQRSLAYDRAWWFARFVAAAYGTAKLRELYL FT ATCGVGHFDLATAAHDVLGIDAAGLLARWQRWLMG" FT CDS complement(226148..227305) FT /transl_table=11 FT /gene="Mb2213c" FT /locus_tag="Mb2213c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2213c, -, len: 385 aa. Equivalent to Rv2190c, len: FT 385 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 385 aa overlap). Conserved hypothetical FT protein; similar to other hypothetical mycobacterial FT proteins, including Rv1477, Rv1478, Rv1566c, Rv0024, that FT are similar to protein p60 precursors from Listeria eg Q018 FT 38|P60_LISSE protein p60 precursor (invasion-associated FT protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 FT a a) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa FT overlap and sp|Q01838|P60_LISSE PROTEIN P60 PRECURSOR (523 FT aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa FT overlap." FT /db_xref="InterPro:IPR000064" FT /db_xref="UniProtKB/Swiss-Prot:P67474" FT /protein_id="CAD97066.1" FT /translation="MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDALA FT KLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAARARLATFQTAVN FT KVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAHQMSTQMARFKAAGEQAVKAE FT QAAAKSAADARSAAEQAAAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALADPGPV FT PAVAAIAPGAPPAALPPGAPPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAVVQAAL FT TQVGAPYAWGGAAPGGFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPGDVL FT TFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY" FT CDS 227852..229789 FT /transl_table=11 FT /gene="Mb2214" FT /locus_tag="Mb2214" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2214, -, len: 645 aa. Equivalent to Rv2191, len: FT 645 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 645 aa overlap). Conserved hypothetical FT protein, similar to SW:DP3A_B ACSU P13267 DNA polymerase FT III, alpha chain (31.3% identity in 249 aa overlap) and FT SW:UVRC_ECOLI P07028 excinuclease ABC subunit C (25.7% FT identity in 230 aa overlap). Also similar to M. FT tuberculosis Rv3711c (dnaQ DNA polymerase III e chain) and FT Rv1420 (uvrC excinuclease ABC subunit C)" FT /db_xref="GOA:Q7TYX5" FT /db_xref="InterPro:IPR000305" FT /db_xref="UniProtKB/TrEMBL:Q7TYX5" FT /protein_id="CAD97067.1" FT /translation="MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFVV FT VDLETTGGRTTGNDATPPDAITEIGAVKVCGGAVLGEFATLVNPQHSIPPQIVRLTGIT FT TAMVGNAPTIDAVLPMFFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLCTMR FT LARRVLSRDEAPSVRLAALARLFAVASNPTHRALDDARATVDVLHALIERVGNQGVHTY FT AELRSYLPNVTQAQRCKRVLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVSQYFNG FT TDRRKRMTEMVMLASSIDHVECAHPLEAGVRELRMLSTHAPPYNRRSKFPYRWWWVALT FT DEAFPRLSVIRAPRHDRVVGPFRSRSKAAETTALLARCTGLRTCTTRLTRSARHGPACP FT ELEVSACPAARDVTAAQYAEAVLRAAALIGGLDNAALAAAVQQVTELAERRRYESAARL FT RDHLATAIEALWHGQRLRALAALPELIAAKPDGPREGGYQLAVIRHGQLAAAGRAPRGV FT PPMPVVDAIRRGAQAILPTPAPLGGALVEEIALIARWLAEPGVRIVGVSNDAAGLASPV FT RSAGPWAAWAATARSAQLAGEQLSRGWQSDLPTEPHPSREQLFGRTGVDCRTGPPQPLL FT PGRQPFSTAG" FT CDS complement(229664..230776) FT /transl_table=11 FT /gene="trpD" FT /locus_tag="Mb2215c" FT /product="Probable anthranilate phosphoribosyltransferase FT TrpD" FT /EC_number="2.4.2.18" FT /note="Mb2215c, trpD, len: 370 aa. Equivalent to Rv2192c, FT len: 370 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 370 aa overlap). Probable trpD, FT anthranilate phosphoribosyltransferase (EC 2.4.2.18) (see FT citation below), similar to e.g. TRPD_LACCA|P17170, (43.2% FT identity in 308 aa overlap). Initiation codon uncertain, FT gtg at 4086 in MTCY190 favoured by homology but this has no FT clear ribosome binding site." FT /db_xref="GOA:P66993" FT /db_xref="HSSP:1KGZ" FT /db_xref="InterPro:IPR000312" FT /db_xref="UniProtKB/Swiss-Prot:P66993" FT /protein_id="CAD97068.1" FT /translation="MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQA FT AWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVD FT VVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPD FT LVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCA FT FADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGF FT ARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAW FT EEGLRRASAAIDTGAAEQLLARWVRFGRQI" FT CDS 230934..231545 FT /transl_table=11 FT /gene="ctaE" FT /locus_tag="Mb2216" FT /product="PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE" FT /EC_number="1.9.3.1" FT /note="Mb2216, ctaE, len: 203 aa. Equivalent to Rv2193, FT len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 203 aa overlap). Probable ctaE, FT cytochrome c oxidase polypeptide III (cox3) (EC 1.9.3.1), FT with strong similarity to others e.g. COX3_SYNY3|Q06475 FT (29.8% identity in 225 aa overlap)." FT /db_xref="GOA:P63857" FT /db_xref="InterPro:IPR013833" FT /db_xref="UniProtKB/Swiss-Prot:P63857" FT /protein_id="CAD97069.1" FT /translation="MTSAVGTSGTAITSRVHSLNRPNMVSVGTIVWLSSELMFFAGLFA FT FYFSARAQAGGNWPPPPTELNLYQAVPVTLVLIASSFTCQMGVFAAERGDIFGLRRWYV FT ITFLMGLFFVLGQAYEYRNLMSHGTSIPSSAYGSVFYLATGFHGLHVTGGLIAFIFLLV FT RTGMSKFTPAQATASIVVSYYWHFVDIVWIALFTVIYFIR" FT CDS 231586..232428 FT /transl_table=11 FT /gene="qcrC" FT /locus_tag="Mb2217" FT /product="Probable Ubiquinol-cytochrome C reductase QcrC FT (cytochrome C subunit)" FT /note="Mb2217, qcrC, len: 280 aa. Equivalent to Rv2194, FT len: 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 280 aa overlap). Probable qcrC, FT Ubiquinol-cytochrome C reductase cytochrome C subunit FT (cyoA), shows similarity to cytochrome c family; contains 2 FT X PS00190 Cytochrome c family heme-binding site signature." FT /db_xref="GOA:P63888" FT /db_xref="HSSP:1C6S" FT /db_xref="InterPro:IPR009152" FT /db_xref="UniProtKB/Swiss-Prot:P63888" FT /protein_id="CAD97070.1" FT /translation="MTKLGFTRSGGSKSGRTRRRLRRRLSGGVLLLIALTIAGGLAAVL FT TPTPQVAVADESSSALLRTGKQLFDTSCVSCHGANLQGVPDHGPSLIGVGEAAVYFQVS FT TGRMPAMRGEAQAPRKDPIFDEAQIDAIGAYVQANGGGPTVVRNPDGSIATQSLRGNDL FT GRGGDLFRLNCASCHNFTGKGGALSSGKYAPDLAPANEQQILTAMLTGPQNMPKFSNRQ FT LSFEAKKDIIAYVKVATEARQPGGYLLGGFGPAPEGMAMWIIGMVAAIGLALWIGARS" FT CDS 232425..233714 FT /transl_table=11 FT /gene="qcrA" FT /locus_tag="Mb2218" FT /product="Probable Rieske iron-sulfur protein QcrA" FT /note="Mb2218, qcrA, len: 429 aa. Equivalent to Rv2195, FT len: 429 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 429 aa overlap). Probable qcrA, FT Ubiquinol-cytochrome C reductase iron-sulfur subunit FT (cyoB), shows some similarity to cytochrome B6-F complex FT iron-sulphur subunits (Rieske iron-sulfur protein); FT contains PS00200 Rieske iron-sulfur protein signature 2" FT /db_xref="GOA:Q7TYX4" FT /db_xref="HSSP:1G8J" FT /db_xref="InterPro:IPR017941" FT /db_xref="UniProtKB/Swiss-Prot:Q7TYX4" FT /protein_id="CAD97071.1" FT /translation="MSRADDDAVGVPPTCGGRSDEEERRIVPGPNPQDGAKDGAKATAV FT PREPDEAALAAMSNQELLALGGKLDGVRIAYKEPRWPVEGTKAEKRAERSVAVWLLLGG FT VFGLALLLIFLFWPWEFKAADGESDFIYSLTTPLYGLTFGLSILSIAIGAVLYQKRFIP FT EEISIQERHDGASREIDRKTVVANLTDAFEGSTIRRRKLIGLSFGVGMGAFGLGTLVAF FT AGGLIKNPWKPVVPTAEGKKAVLWTSGWTPRYQGETIYLARATGTEDGPPFIKMRPEDI FT DAGGMETVFPWRESDGDGTTVESHHKLQEIAMGIRNPVMLIRIKPSDLGRVVKRKGQES FT FNFGEFFAFTKVCSHLGCPSSLYEQQSYRILCPCHQSQFDALHFAKPIFGPAARALAQL FT PITIDTDGYLVANGDFVEPVGPAFWERTTT" FT CDS 233711..235360 FT /transl_table=11 FT /gene="qcrB" FT /locus_tag="Mb2219" FT /product="Probable Ubiquinol-cytochrome C reductase QcrB FT (cytochrome B subunit)" FT /note="Mb2219, qcrB, len: 549 aa. Equivalent to Rv2196, FT len: 549 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 549 aa overlap). Probable qcrB, FT Ubiquinol-cytochrome C reductase cytochrome B subunit FT (cytB), integral membrane protein, low similarity in FT amino-terminal half to cytochrome b subunits, highly FT similar at C-terminus to SW:12KD_MYCLE P15878 12 KD protein FT PIR:S08427 (86.9% identity in 153 aa overlap). FASTA FT scores: sp|Q45658|QCRB_BACST MENAQUINOL-CYTOCHROME C FT REDUCTASE (224 aa) opt: 341, E(): 6.8e-15; 28.0% identity FT in 207 aa overlap" FT /db_xref="GOA:P63886" FT /db_xref="InterPro:IPR005797" FT /db_xref="UniProtKB/Swiss-Prot:P63886" FT /protein_id="CAD97072.1" FT /translation="MSPKLSPPNIGEVLARQAEDIDTRYHPSAALRRQLNKVFPTHWSF FT LLGEIALYSFVVLLITGVYLTLFFDPSMVDVTYNGVYQPLRGVEMSRAYQSALDISFEV FT RGGLFVRQIHHWAALMFAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEGYFG FT YSLPDDLLSGLGLRAALSSITLGMPVIGTWLHWALFGGDFPGTILIPRLYALHILLLPG FT IILALIGLHLALVWFQKHTQFPGPGRTEHNVVGVRVMPVFAFKSGAFFAAIVGVLGLMG FT GLLQINPIWNLGPYKPSQVSAGSQPDFYMMWTEGLARIWPPWEFYFWHHTIPAPVWVAV FT IMGLVFVLLPAYPFLEKRFTGDYAHHNLLQRPRDVPVRTAIGAMAIAFYMVLTLAAMND FT IIALKFHISLNATTWIGRIGMVILPPFVYFITYRWCIGLQRSDRSVLEHGVETGIIKRL FT PHGAYIELHQPLGPVDEHGHPIPLQYQGAPLPKRMNKLGSAGSPGSGSFLFADSAAEDA FT ALREAGHAAEQRALAALREHQDSIMGSPDGEH" FT CDS complement(235651..236295) FT /transl_table=11 FT /gene="Mb2220c" FT /locus_tag="Mb2220c" FT /product="Probable conserved transmembrane protein" FT /note="Mb2220c, -, len: 214 aa. Equivalent to Rv2197c, len: FT 214 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 214 aa overlap). Probable conserved FT transmembrane protein, equivalent to ML0878 conserved FT hypothetical protein (212 aa) of Mycobacterium leprae. FT FASTA scores: opt: 858; 62.559% identity in 211 aa overlap FT CAC31259.1|(AL583920)" FT /db_xref="GOA:Q7VEN7" FT /db_xref="UniProtKB/TrEMBL:Q7VEN7" FT /protein_id="CAD97073.1" FT /translation="MVSRYSAYRRGPDVISPDVIDRILVGACAAVWLVFTGVSVAAAVA FT LMDLGRGFHEMAGNPHTTWVLYAVIVVSALVIVGAIPVLLRARRMAEAEPATRPTGASV FT RGGRSIGSGHPAKRAVAESAPVQHADAFEVAAEWSSEAVDRIWLRGTVVLTSAIGIALI FT AVAAATYLMAVGHDGPSWISYGLAGVVTAGMPVIEWLYSRQLRRVVAPQSS" FT CDS complement(236295..237194) FT /transl_table=11 FT /gene="mmpS3" FT /locus_tag="Mb2221c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS3" FT /note="Mb2221c, mmpS3, len: 299 aa. Equivalent to Rv2198c, FT len: 299 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 299 aa overlap). Probable mmpS3, FT conserved membrane protein (see citation below), equivalent FT to ML0877|mmpS3 putative membrane protein from FT Mycobacterium leprae (293 aa), FASTA scores: opt: 1089, FT E(): 1.2e-43, (69.80% identity in 308 aa overlap). Also FT similar to other proteins e.g. Rv3209 from Mycobacterium FT tuberculosis. Contains PS00499 C2 domain signature, a FT hydrophobic region, and a repetitive proline and threonine FT rich region. BELONGS TO THE MMPS FAMILY." FT /db_xref="GOA:P65379" FT /db_xref="UniProtKB/Swiss-Prot:P65379" FT /protein_id="CAD97074.1" FT /translation="MSGPNPPGREPDEPESEPVSDTGDERASGNHLPPVAGGGDKLPSD FT QTGETDAYSRAYSAPESEHVTGGPYVPADLRLYDYDDYEESSDLDDELAAPRWPWVVGV FT AAIIAAVALVVSVSLLVTRPHTSKLATGDTTSSAPPVQDEITTTKPAPPPPPPAPPPTT FT EIPTATETQTVTVTPPPPPPPATTTAPPPATTTTAAAPPPTTTTPTGPRQVTYSVTGTK FT APGDIISVTYVDAAGRRRTQHNVYIPWSMTVTPISQSDVGSVEASSLFRVSKLNCSITT FT SDGTVLSSNSNDGPQTSC" FT CDS complement(237380..237799) FT /transl_table=11 FT /gene="Mb2222c" FT /locus_tag="Mb2222c" FT /product="Possible conserved integral membrane protein" FT /note="Mb2222c, -, len: 139 aa. Equivalent to Rv2199c, len: FT 139 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 139 aa overlap). Possible conserved FT integral membrane protein, similar to hypothetical membrane FT proteins in Actinomycetes and equivalent to Mycobacterium FT leprae, ML0876, putative membrane protein (139 aa) FASTA FT scores: opt: 866, E(): 1.1e-43; 91.367% identity in 139 aa FT overlap CAC31257.1| (AL583920)" FT /db_xref="GOA:P64948" FT /db_xref="UniProtKB/Swiss-Prot:P64948" FT /protein_id="CAD97075.1" FT /translation="MHIEARLFEFVAAFFVVTAVLYGVLTSMFATGGVEWAGTTALALT FT GGMALIVATFFRFVARRLDSRPEDYEGAEISDGAGELGFFSPHSWWPIMVALSGSVAAV FT GIALWLPWLIAAGVAFILASAAGLVFEYYVGPEKH" FT CDS complement(237807..238898) FT /transl_table=11 FT /gene="ctaC" FT /locus_tag="Mb2223c" FT /product="PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE FT (SUBUNIT II) CTAC" FT /EC_number="1.9.3.1" FT /note="Mb2223c, ctaC, len: 363 aa. Equivalent to Rv2200c, FT len: 363 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 363 aa overlap). Probable ctaC, FT transmembrane cytochrome C oxidase (subunit II), COX2, FT similar e.g. to JT0964 cytochrome-c oxidase chain II (23.0% FT identity in 317 aa overlap); etc. Contains PS00078 FT Cytochrome c oxidase subunit II, copper A binding region FT signature. BELONGS TO THE CYTOCHROME C OXIDASE SUBUNIT 2 FT FAMILY." FT /db_xref="GOA:P63855" FT /db_xref="InterPro:IPR002429" FT /db_xref="UniProtKB/Swiss-Prot:P63855" FT /protein_id="CAD97076.1" FT /translation="MTPRGPGRLQRLSQCRPQRGSGGPARGLRQLALAAMLGALAVTVS FT GCSWSEALGIGWPEGITPEAHLNRELWIGAVIASLAVGVIVWGLIFWSAVFHRKKNTDT FT ELPRQFGYNMPLELVLTVIPFLIISVLFYFTVVVQEKMLQIAKDPEVVIDITSFQWNWK FT FGYQRVNFKDGTLTYDGADPERKRAMVSKPEGKDKYGEELVGPVRGLNTEDRTYLNFDK FT VETLGTSTEIPVLVLPSGKRIEFQMASADVIHAFWVPEFLFKRDVMPNPVANNSVNVFQ FT IEEITKTGAFVGHCAEMCGTYHSMMNFEVRVVTPNDFKAYLQQRIDGKTNAEALRAINQ FT PPLAVTTHPFDTRRGELAPQPVG" FT CDS 239144..241102 FT /transl_table=11 FT /gene="asnB" FT /locus_tag="Mb2224" FT /product="Probable asparagine synthetase AsnB" FT /EC_number="6.3.5.4" FT /note="Mb2224, asnB, len: 652 aa. Equivalent to Rv2201, FT len: 652 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 652 aa overlap). Probable asnB, FT asparagine synthetase, similar to e.g. SW:ASNH_BACSU P42113 FT putative asparagine synthetase (26.0% identity in 438 aa FT overlap)" FT /db_xref="GOA:P64248" FT /db_xref="HSSP:1CT9" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:P64248" FT /protein_id="CAD97077.1" FT /translation="MCGLLAFVAAPAGAAGPEGADAASAIARASHLMRHRGPDESGTWH FT AVDGASGGVVFGFNRLSIIDIAHSHQPLRWGPPEAPDRYVLVFNGEIYNYLELRDELRT FT QHGAVFATDGDGEAILAGYHHWGTEVLQRLRGMFAFALWDTVTRELFCARDPFGIKPLF FT IATGAGGTAVASEKKCLLDLVELVGFDTEIDHRALQHYTVLQYVPEPETLHRGVRRLES FT GCFARIRADQLAPVITRYFVPRFAASPITNDNDQARYDEITAVLEDSVAKHMRADVTVG FT AFLSGGIDSTAIAALAIRHNPRLITFTTGFEREGFSEIDVAVASAEAIGARHIAKVVSA FT DEFVAALPEIVWYLDEPVADPALVPLFFVAREARKHVKVVLSGEGADELFGGYTIYREP FT LSLRPFDYLPKPLRRSMGKVSKPLPEGMRGKSLLHRGSLTLEERYYGNARSFSGAQLRE FT VLPGFRPDWTHTDVTAPVYAESAGWDPVARMQHIDLFTWLRGDILVKADKITMANSLEL FT RVPFLDPEVFAVASRLPAGAKITRTTTKYALRRALEPIVPAHVLHRPKLGFPVPIRHWL FT RAGELLEWAYATVGSSQAGHLVDIAAVYRMLDEHRCGSSDHSRRLWTMLIFMLWHAIFV FT EHSVVPQISEPQYPVQL" FT CDS complement(241200..242174) FT /transl_table=11 FT /gene="cbhK" FT /locus_tag="Mb2225c" FT /product="Probable carbohydrate kinase CbhK" FT /EC_number="2.7.-.-" FT /note="Mb2225c, cbhK, len: 324 aa. Equivalent to Rv2202c, FT len: 324 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 324 aa overlap). Probable cbhK, FT carbohydrate kinase (but not ribose) (EC 2.7.-.-), similar FT to several e.g. AE000915_1 Methanobacterium thermoautotrop FT (309 aa) FASTA score: opt: 370, E(): 3.3e-18; 31.2% FT identity in 276 aa overlap. Low similarity to carbohydrate FT kinases, e.g. SW:RBSK_BACSU P36945 ribokinase (23.9% FT identity in 272 aa overlap); contains PS00583 pfkB family FT of carbohydrate kinases signature 1" FT /db_xref="GOA:P83736" FT /db_xref="InterPro:IPR002173" FT /db_xref="UniProtKB/Swiss-Prot:P83736" FT /protein_id="CAD97078.1" FT /translation="MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMH FT RGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTC FT TTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLG FT LAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVT FT TLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGS FT LVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAVLA" FT CDS 242378..243070 FT /transl_table=11 FT /gene="Mb2226" FT /locus_tag="Mb2226" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb2226, -, len: 230 aa. Equivalent to Rv2203, len: FT 230 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 230 aa overlap). Possible conserved FT membrane protein; has single hydrophobic stretch from aa 75 FT to 97 and is equivalent to Mycobacterium leprae ML0872 FT putative membrane protein (171 aa). FASTA scores: opt: 821, FT E(): 3.4e-42; 72.353% identity in 170 aa overlap - FT CAC31253.1| (AL583920). 2468411." FT /db_xref="GOA:P64950" FT /db_xref="UniProtKB/Swiss-Prot:P64950" FT /protein_id="CAD97079.1" FT /translation="MPGPHSPNPGVGTNGPAPYPEPSSHEPQALDYPHDLGAAEPAFAP FT GPADDAALPPAAYPGVPPQVSYPKRRHKRLLIGIVVALALVSAMTAAIIYGVRTNGANT FT AGTFSEGPAKTAIQGYLNALENRDVDTIVRNALCGIHDGVRDKRSDQALAKLSSDAFRK FT QFSQVEVTSIDKIVYWSQYQAQVLFTMQVTPAAGGPPRGQVQGIAQLLFQRGQVLVCSY FT VLRTAGSY" FT CDS complement(243078..243434) FT /transl_table=11 FT /gene="Mb2227c" FT /locus_tag="Mb2227c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2227c, -, len: 118 aa. Equivalent to Rv2204c, len: FT 118 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 118 aa overlap). Conserved hypothetical FT protein. Similar to conserved hypothetical proteins in FT Actinomycetes and equivalent to Mycobacterium leprae FT ML0871|ML0871 conserved hypothetical protein (118 aa) and FT to sp|P45344|YADR_HAEIN HYPOTHETICAL PROTEIN HI1723 (114 FT aa). FASTA score: ML0871 opt: 720, E(): 8.4e-45; 92.373% FT identity in 118 aa overlapCAC31252.1| (AL583920); and FT P45344 opt: 346, E(): 1.8e-18; 45.6% identity in 103 aa FT overlap. Contains PS01152 Hypothetical hesB/y yadR/yfhF FT family signature" FT /db_xref="GOA:P0A5B0" FT /db_xref="HSSP:1NWB" FT /db_xref="InterPro:IPR017870" FT /db_xref="UniProtKB/Swiss-Prot:P0A5B0" FT /protein_id="CAD97080.1" FT /translation="MTVQNEPSAKTHGVILTEAAAAKAKSLLDQEGRDDLALRIAVQPG FT GCAGLRYNLFFDDRTLDGDQTAEFGGVRLIVDRMSAPYVEGASIDFVDTIEKQGFTIDN FT PNATGSCACGDSFN" FT CDS complement(243534..244610) FT /transl_table=11 FT /gene="Mb2228c" FT /locus_tag="Mb2228c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2228c, -, len: 358 aa. Equivalent to Rv2205c, len: FT 358 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 358 aa overlap). Conserved hypothetical FT protein. Very similar to YHAD_ECOLI|P23524 hypothetical FT protein (YHAD (E.coli) / YXAA (S14A) (B.subtilis) family) FT (41.6% identity in 154 aa overlap), and to other members of FT the glycerate kinase family. Start changed since first FT submission; protein now 122 aa shorter, owing to extension FT of Rv2206." FT /db_xref="GOA:P64289" FT /db_xref="InterPro:IPR004381" FT /db_xref="UniProtKB/Swiss-Prot:P64289" FT /protein_id="CAD97081.1" FT /translation="MRVLVAPDCYGDSLSAVEAAAAIATGWTRSRPGDSFIVAPQSDGG FT PGFVEVLGSRLGETRRLRVCGPLNTVVNAAWVFDPGSATAYLECAQACGLGLLGGPPTP FT ETALAAHSKGVGQLIAAALRAGAARIVVGLGGSACTDGGKGMIAELGGLDAARRQLADV FT EVIAASDVEYPLLGPWGTARVFAPQKGADMATVAVLEGRLAAWAIELDAAAGRGVSAEP FT GAGAAGGIGAGLLAVGGRYQSGAAIIAEHTHFADDLADAELIVTGEGRFDEQSLHGKVV FT GAIAAAARPLAIPVIVLAGQVSLDKSALRSAGIMAALSIAEYAGSVRLALADAANQLMG FT LASQVAARLGNSGPSGYR" FT CDS 244769..245479 FT /transl_table=11 FT /gene="Mb2229" FT /locus_tag="Mb2229" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb2229, -, len: 236 aa. Equivalent to Rv2206, len: FT 236 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 236 aa overlap). Probable conserved FT transmembrane protein. Equivalent to hypothetical protein FT ML0869 (247 aa) of Mycobacterium leprae gZ98741|MLCB22_2 FT (247 aa), FASTA scores: opt: 1052, (67.5% identity in 237 FT aa overlap). Two hydrophobic stretches in C-terminal part. FT Start changed since original submission (+112 aa)." FT /db_xref="GOA:P64952" FT /db_xref="UniProtKB/Swiss-Prot:P64952" FT /protein_id="CAD97082.1" FT /translation="MKLLGHRKSHGHQRADASPDAGSKDGCRPDSGRTSGSDTSRGSQT FT TGPKGRPTPKRNQSRRHTKKGPVAPAPMTAAQARARRKSLAGPKLSREERRAEKAANRA FT RMTERRERMMAGEEAYLLPRDRGPVRRYVRDVVDSRRNLLGLFMPSALTLLFVMFAVPQ FT VQFYLSPAMLILLALMTIDAIILGRKVGRLVDTKFPSNTESRWRLGLYAAGRASQIRRL FT RAPRPQVERGGDVG" FT CDS 245558..246643 FT /transl_table=11 FT /gene="cobT" FT /locus_tag="Mb2230" FT /product="Probable FT nicotinate-nucleotide-dimethylbenzimidazol FT phosphoribosyltransferase CobT" FT /EC_number="2.4.2.21" FT /note="Mb2230, cobT, len: 361 aa. Equivalent to Rv2207, FT len: 361 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 361 aa overlap). Probable cobT, FT phosphoribosyltransferase, similar to many e.g. FT SW:COBT_ECOLI P36562 FT nicotinate-nucleotide--dimethylbenzimidazol FT phosphoribosyltransferase (34.6% identity in 341 aa FT overlap)" FT /db_xref="GOA:P63842" FT /db_xref="HSSP:1D0V" FT /db_xref="InterPro:IPR017846" FT /db_xref="UniProtKB/Swiss-Prot:P63842" FT /protein_id="CAD97083.1" FT /translation="MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASC FT QQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVAGA FT TVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEVDAG FT ADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVR FT PVLPDPVGLLRCAGGADLAAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRW FT WQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTE FT AGVSTRSVDGVDRTAPPAVSP" FT CDS 246640..247389 FT /transl_table=11 FT /gene="cobS" FT /locus_tag="Mb2231" FT /product="Probable cobalamin 5'-phosphate synthase CobS" FT /EC_number="2.-.-.-" FT /note="Mb2231, cobS, len: 249 aa. Equivalent to Rv2208, FT len: 249 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 249 aa overlap). Probable cobS, FT cobalamin 5'-phosphate synthase; similarity to FT SW:COBS_ECOLI P36561 cobalamin (5'-phosphate) synthase FT (28.0% identity in 243 aa overlap)" FT /db_xref="GOA:Q7VEN6" FT /db_xref="InterPro:IPR003805" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEN6" FT /protein_id="CAD97084.1" FT /translation="MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAA FT AIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRD FT GSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRSVPAAHGST FT LGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGG FT VTGDVLGSAIELSTTVSAVTLAGLARL" FT CDS 247547..249085 FT /transl_table=11 FT /gene="Mb2232" FT /locus_tag="Mb2232" FT /product="Probable conserved integral membrane protein" FT /note="Mb2232, -, len: 512 aa. Equivalent to Rv2209, len: FT 512 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 512 aa overlap). Probable conserved FT integral membrane protein, similar to but longer than FT Rv0246 gp|AL021929|MTV 034_12 Mycobacterium tuberculosis FT (436 aa). FASTA score: opt: 712, E(): 2.8e- 32; 33.4% FT identity in 422 aa overlap" FT /db_xref="GOA:P64954" FT /db_xref="UniProtKB/Swiss-Prot:P64954" FT /protein_id="CAD97085.1" FT /translation="MPASRLVRQVSAPRNLFGRLVAQGGFYTAGLQLGSGAVVLPVICA FT HQGLTWAAGLLYPAFCIGAILGNSLSPLILQRAGQLRHLLMAAISATAAALVVCNAAVP FT WTGVGVAAVFLATTGAGGVVTGVSSVAYTDMISSMLPAVRRGELLLTQGAAGSVLATGV FT TLVIVPMLAHGNEMARYHDLLWLGAAGLVCSGIAALFVGPMRSVSVTTATRMPLREIYW FT MGFAIARSQPWFRRYMTTYLLFVPISLGTTFFSLRAAQSNGSLHVLVILSSIGLVVGSM FT LWRQINRLFGVRGLLLGSALLNAAAALLCMVAESCGQWVHAWAYGTAFLLATVAAQTVV FT AASISWISVLAPERYRATLICVGSTLAAVEATVLGVALGGIAQKHATIWPVVVVLTLAV FT IAAVASLRAPTRIGVTADTSPQAATLQAYRPATPNPIHSDERSTPPDHLSVRRGQLRHV FT WDSRRPAPPLNRPSCRRAARRPAPGKPAAALPQPRHPAVGVREGAPLDAGQRIA" FT CDS complement(249011..250117) FT /transl_table=11 FT /gene="ilvE" FT /locus_tag="Mb2233c" FT /product="PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE FT ILVE" FT /EC_number="2.6.1.42" FT /note="Mb2233c, ilvE, len: 368 aa. Equivalent to Rv2210c, FT len: 368 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 368 aa overlap). Probable ilvE, FT Branched-chain-amino-acid transaminase, highly similar to FT many e.g. YWAA_BACSU|P39576 from Bacillus subtilis (48.4% FT identity in 339 aa overlap); etc." FT /db_xref="GOA:Q7TYX3" FT /db_xref="HSSP:1EKF" FT /db_xref="InterPro:IPR005786" FT /db_xref="UniProtKB/TrEMBL:Q7TYX3" FT /protein_id="CAD97086.1" FT /translation="MTSGSLQFTVLRAVNPATDAQRESMLRAPGFGKYHTDHMVSIDYA FT EGRGWHNARVIPYGPIELDPSAIVLHYAQEVFEGLKAYRWADGSIVSFRADANAARLRS FT SARRLAIPELPDAVFIESLRQLIAVDKAWVPGAGGEEALYLRPFIFATEPGLGVRPATQ FT YRYLLIASPAGAYFKGGIAPVSVWVSTEYVRACPGGTGAAKFGGNYAASLLAQAEAAEN FT GCDQVVWLDAVERRYIEEMGGMNIFFVLGSGGSARLVTPELSGSLLPGITRDSLLQLAI FT DAGFAVEERRIDIDEWQKKAAAGEITEVFACGTAAVITPVARVRHGASEFRIADGQPGE FT VTMALRDTLTGIQRGTFADTHGWMARLG" FT CDS complement(250189..251328) FT /transl_table=11 FT /gene="gcvT" FT /locus_tag="Mb2234c" FT /product="Probable aminomethyltransferase GcvT (Glycine FT cleavage system T protein)" FT /EC_number="2.1.2.10" FT /note="Mb2234c, gcvT, len: 379 aa. Equivalent to Rv2211c, FT len: 379 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 379 aa overlap). Probable gcvT, FT aminomethyltransferase (EC 2.1.2.10), similar to many e.g. FT GCST_ECOLI|P27248 for Escherichia coli (38.2% identity in FT 364 aa overlap); etc. BELONGS TO THE GCVT FAMILY." FT /db_xref="GOA:P64221" FT /db_xref="InterPro:IPR006223" FT /db_xref="UniProtKB/Swiss-Prot:P64221" FT /protein_id="CAD97087.1" FT /translation="MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPV FT SYAGTVSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQYTLC FT CTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAVLAV FT QGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVF FT DALLAAVSAAGGEPAGLGARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFF FT GRAALLAEKAAGPRRLLRGLRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGL FT ALIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR" FT CDS 251337..252473 FT /transl_table=11 FT /gene="Mb2235" FT /locus_tag="Mb2235" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2235, -, len: 378 aa. Equivalent to Rv2212, len: FT 378 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 378 aa overlap). Conserved hypothetical FT protein. Some similarity to adenylate cyclases, e.g. FT SW:CYAA_STRCO P40135 (29.2% identity in 291 aa overlap); FT ttg at 24614 in MTCY190 has a better rbs. Contains possible FT helix-turn-helix motif at aa 64- 85, (+2.72 SD). Also FT similar to Rv1264 and Rv1647" FT /db_xref="GOA:P64266" FT /db_xref="HSSP:1AWK" FT /db_xref="InterPro:IPR001054" FT /db_xref="UniProtKB/Swiss-Prot:P64266" FT /protein_id="CAD97088.1" FT /translation="MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRG FT RLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVD FT ALATWVALKALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATAR FT AYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQ FT ALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPG FT ARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPA FT LAHGPLTLKGFDAPVMAFELHDNPRARDADTPSPAASD" FT CDS 252485..254032 FT /transl_table=11 FT /gene="pepB" FT /locus_tag="Mb2236" FT /product="Probable aminopeptidase PepB" FT /EC_number="3.4.11.1" FT /note="Mb2236, pepB, len: 515 aa. Equivalent to Rv2213, FT len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 515 aa overlap). Probable pepB, leucine FT aminopeptidase, similar to many e.g. SW:AMPA_ECOLI P11648 FT aminopeptidase A/I, (41.4% identity in 309 aa overlap). FT Equivalent to Z98741|MLCB22_6 Mycobacterium leprae cosmid FT B22; Am (524 aa), FASTA scores: opt: 2793, E(): 0; 83.1% FT identity in 522 aa overlap. Contains PS00631 Cytosol FT aminopeptidase signature, NTDAEGRL" FT /db_xref="GOA:Q7VEN5" FT /db_xref="HSSP:1GYT" FT /db_xref="InterPro:IPR008283" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEN5" FT /protein_id="CAD97089.1" FT /translation="MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVV FT ASAEPFLRADTVAEIEAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPAD FT TIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDA FT GLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAELAKRAKTLSESVG FT LDVEVIDEKALKKAGYGGVIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGI FT TFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATA FT QRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGT FT RIPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLV FT AGVFLREFVAESVDWAHIDVAGPAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG" FT CDS complement(254070..255848) FT /transl_table=11 FT /gene="ephD" FT /locus_tag="Mb2237c" FT /product="Possible short-chain dehydrogenase EphD" FT /EC_number="1.-.-.-" FT /note="Mb2237c, ephD, len: 592 aa. Equivalent to Rv2214c, FT len: 592 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 592 aa overlap). Possible ephD, FT short-chain dehydrogenase (EC 1.-.-.-) (see citation FT below), equivalent to Z98741|MLCB22_8 Mycobacterium leprae FT cosmid B22; (596 aa), FASTA score: opt: 3262, E(): 0; 80.4% FT identity in 596 aa overlap. C-terminus similar to FT short-chain alcohol dehydrogenase family, similar to FT SW:LIGD_PSEPA Q01198 c alpha-dehydrogenase (30.7% identity FT in 241 aa overlap); contains PS00061 Short-chain alcohol FT dehydrogenase family signature, PS00697 ATP-dependent DNA FT ligase AMP-binding site. N-terminus corresponds to several FT epoxide hydrolases of plants and Mycobacterium tuberculosis FT e.g. MTCY9F925" FT /db_xref="GOA:P66778" FT /db_xref="HSSP:1FDS" FT /db_xref="InterPro:IPR002347" FT /db_xref="UniProtKB/Swiss-Prot:P66778" FT /protein_id="CAD97090.1" FT /translation="MPATQQMSRLVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLW FT DGVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSPGEPVHVLA FT HDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGGLRRPWRPRTFLRAISQT FT LRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDIPVDQIHHSETLARDAAHSVKTYP FT ANYFRSFSSSRRGRAIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHF FT SPMSHPQVMAAAVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRET FT ALAFAREGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVSAEH FT GVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQRLVERGTGGHIVN FT VSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAGVGLTTICPGVIDTNIVATTGF FT HAPGTDEEKIDGRRGQIDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGIS FT RVLPQALRSTARLRVI" FT CDS 256112..257773 FT /transl_table=11 FT /gene="sucB" FT /locus_tag="Mb2238" FT /product="Probable pyruvate dehydrogenase (E2 component) FT SucB" FT /EC_number="2.3.1.61" FT /note="Mb2238, sucB, len: 553 aa. Equivalent to Rv2215, FT len: 553 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 553 aa overlap). Probable sucB, FT dihydrolipoamide acetyltransferase component (E2), similar FT to e.g. SW:O PD2_ACHLA P35489 dihydrolipoamide FT acetyltransferase component (E2) of pyruvate dehydrogenase FT complex (35.3% identity in 552 aa overlap); contains FT PS00189 2-oxo acid dehydrogenases acyltransferase component FT lipoyl binding site." FT /db_xref="GOA:P65634" FT /db_xref="HSSP:1C4T" FT /db_xref="InterPro:IPR004167" FT /db_xref="UniProtKB/Swiss-Prot:P65634" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97091.1" FT /translation="MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVD FT TEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAP FT EPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKV FT DTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPK FT AEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAE FT QKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATA FT QLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNED FT TKEITYYDAEHLGFAVDTEQGLLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDEL FT SGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYL FT PLTYDHRLIDGADAGRFLTTIKHRLEEGAFEADLGL" FT CDS 257773..258678 FT /transl_table=11 FT /gene="Mb2239" FT /locus_tag="Mb2239" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb2239, -, len: 301 aa. Equivalent to Rv2216, len: FT 301 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 301 aa overlap). Conserved hypothetical FT protein, equivalent to Mycobacterium leprae ML0860 (307 FT aa), Z98741|MLCB22_10 Mycobacterium leprae cosmid B22; H FT (307 aa). FASTA score: opt: 1656, E(): 0; 84.2% identity in FT 297 aa overlap. Also gp|AE000319|ECAE000319_8 Escherichia FT coli strain K12 MG1655 (297 aa) opt: 640, E(): 0; 39.5% FT identity in 294 aa overlap." FT /db_xref="GOA:P67233" FT /db_xref="InterPro:IPR010099" FT /db_xref="UniProtKB/Swiss-Prot:P67233" FT /protein_id="CAD97092.1" FT /translation="MANAVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEELH FT WNPESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSAAVADAG FT VATLINASAVGYYGNTKDRVVDENDSAGTGFLAQLCVDWETATRPAQQSGARVVLARTG FT VVLSPAGGMLRRMRPLFSVGLGARLGSGRQYMSWISLEDEVRALQFAIAQPNLSGPVNL FT TGPAPVTNAEFTTAFGRAVNRPTPLMLPSVAVRAAFGEFADEGLLIGQRAIPSALERAG FT FQFHHNTIGEALGYATTRPG" FT CDS 258731..259423 FT /transl_table=11 FT /gene="lipB" FT /locus_tag="Mb2240" FT /product="Probable lipoate biosynthesis protein B LipB" FT /EC_number="6.-.-.-" FT /note="Mb2240, lipB, len: 230 aa. Equivalent to Rv2217, FT len: 230 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 230 aa overlap). Probable lipB, similar FT to SW:LIPB_ECOLI P30976 liopate biosynthesis protein B ( FT 33.8% identity in 160 aa overlap). Equivalent to gp|Z98741| FT MLCB22_11 Mycobacterium leprae (235 aa). FASTA score: opt: FT 1124, E(): 0; 78.4% identity in 218 aa overlap" FT /db_xref="GOA:Q7VEN4" FT /db_xref="InterPro:IPR000544" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEN4" FT /protein_id="CAD97093.1" FT /translation="MTGSIRSKLSAIDVRQLGTVDYRTAWQLQRELADARVAGGADTLL FT LLEHPAVYTAGRRTETHERPIDGTPVVGTDRGGKITWHGPGQLVGYPIIGLAEPLDVVN FT YVRRLEESLIQVCADLGLHAGRVDGRSGVWLPGRPARKVAAIGVRVSRATTLHGFALNC FT DCDLAAFTAIVPCGISDAAVTSLSAELGRTVTVDEVRATVAAAVCAALDGVLPVGDRVP FT SHAVPSPL" FT CDS 259420..260355 FT /transl_table=11 FT /gene="lipA" FT /locus_tag="Mb2241" FT /product="Probable lipoate biosynthesis protein A LipA" FT /note="Mb2241, lipA, len: 311 aa. Equivalent to Rv2218, FT len: 311 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 311 aa overlap). Probable lipA, lipoic FT acid synthetase, similar to e.g. SW:LIPA_HAEIN P44463 (42 FT .6% identity in 291 aa overlap). Equivalent to Z98741|MLCB2 FT 2_12 Mycobacterium leprae cosmid B22; (314 aa). FASTA score FT : opt: 1836, E(): 0; 86.8% identity in 310 aa overlap" FT /db_xref="GOA:P65284" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/Swiss-Prot:P65284" FT /protein_id="CAD97094.1" FT /translation="MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNL FT VRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDRDEPR FT RVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPDFNGEP FT TRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAGLVTKSNLILGL FT GETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFA FT GVLAGPLVRSSYRAGRLYEQARNSRALASR" FT CDS 260382..261134 FT /transl_table=11 FT /gene="Mb2242" FT /locus_tag="Mb2242" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb2242, -, len: 250 aa. Equivalent to Rv2219, len: FT 250 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 250 aa overlap). Probable conserved FT transmembrane protein. Equivalent to hypothetical membrane FT protein ML0857 (250 aa) from Mycobacterium leprae Z98741 FT |MLCB22_13 Mycobacterium leprae cosmid B22; H (250 aa) opt FT : 1328, E(): 0; 80.8% identity in 250 aa overlap." FT /db_xref="GOA:Q7TYX2" FT /db_xref="UniProtKB/TrEMBL:Q7TYX2" FT /protein_id="CAD97095.1" FT /translation="MAKPRNAAESKAAKAQANAARKAAARQRRAQLWQAFTLQRKEDKR FT LLPYMIGAFLLIVGASVGVGVWAGGFTMLTMIPLGVLLGALVAFVIFGRRAQRTVYRKA FT EGQTGAAAWALDNLRGKWRVTPGVAATGNLDAVHRVIGRPGVIFVGEGSAARVKPLLAQ FT EKKRTARLVGDVPIYDIIVGNGDGEVPLAKLERHLTRLPANITVKQMDTVESRLAALGS FT RAGAGVMPKGPLPTTAKMRSVQRTVRRK" FT CDS complement(261141..261563) FT /transl_table=11 FT /gene="Mb2243c" FT /locus_tag="Mb2243c" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb2243c, -, len: 140 aa. Equivalent to Rv2219A, len: FT 140 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 140 aa overlap). Probable membrane FT protein, similar to SC3H12.05c|AL355740_5 possible integral FT membrane protein from Streptomyces coelicolor (155 aa), FT FASTA scores: opt: 327, E(): 7.5e-14, (46.6% identity in FT 133 aa overlap), also linked to glnA." FT /db_xref="InterPro:IPR016795" FT /db_xref="UniProtKB/TrEMBL:Q7TYX1" FT /protein_id="CAD97096.1" FT /translation="MTAKSPPDYPGKTLGLPDTGPGSLAPMGRRLAALLIDWLIAYGLA FT LLGVEFGVWSTPMLSTVVLVIWLLLGVAAVRLFGFTPGQLMLGLVVVAVGGRRPVGIGR FT LVVRGLLIGLVVPPLFTDSDGRGLHDRLTATAVVRR" FT CDS 261762..263198 FT /transl_table=11 FT /gene="glnA1" FT /locus_tag="Mb2244" FT /standard_name="glnA" FT /product="GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) FT (GS-I)" FT /EC_number="6.3.1.2" FT /note="Mb2244, glnA1, len: 478 aa. Equivalent to Rv2220, FT len: 478 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 478 aa overlap). glnA1, glutamine FT synthetase class I (EC 6.3.1.2) (see first citation below), FT similar to many e.g. GLNA_STRCO|P15106 from Streptomyces FT coelicolor, FASTA score: (71.4% identity in 475 aa FT overlap); etc. Also similar to three other potential FT glutamine synthetases in Mycobacterium tuberculosis: FT Rv2222c|glnA2, Rv2860c|glnA4, and Rv1878|glnA3. Contains FT PS00180 Glutamine synthetase signature 1, PS00181 Glutamine FT synthetase putative ATP-binding region signature, and FT PS00182 Glutamine synthetase class-I adenylation site. FT BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY." FT /db_xref="GOA:P0A591" FT /db_xref="InterPro:IPR001637" FT /db_xref="UniProtKB/Swiss-Prot:P0A591" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97097.1" FT /translation="MTEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDKS FT VFDDGLAFDGSSIRGFQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFTLEPY FT SRDPRNIARKAENYLISTGIADTAYFGAEAEFYIFDSVSFDSRANGSFYEVDAISGWWN FT TGAATEADGSPNRGYKVRHKGGYFPVAPNDQYVDLRDKMLTNLINSGFILEKGHHEVGS FT GGQAEINYQFNSLLHAADDMQLYKYIIKNTAWQNGKTVTFMPKPLFGDNGSGMHCHQSL FT WKDGAPLMYDETGYAGLSDTARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINL FT VYSQRNRSACVRIPITGSNPKAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIKNKIEPQA FT PVDKDLYELPPEEAASIPQTPTQLSDVIDRLEADHEYLTEGGVFTNDLIETWISFKREN FT EIEPVNIRPHPYEFALYYDV" FT CDS complement(263516..266500) FT /transl_table=11 FT /gene="glnE" FT /locus_tag="Mb2245c" FT /product="GLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE GLNE FT (Glutamine-synthetase adenylyltransferase)" FT /EC_number="2.7.7.42" FT /note="Mb2245c, glnE, len: 994 aa. Equivalent to Rv2221c, FT len: 994 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 994 aa overlap). glnE, FT glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) FT (see citations below), similar to others e.g. FT GLNE_ECOLI|P30870 glutamate-ammonia-ligase FT adenylyltransferase from Escherichia coli, FASTA score: FT (24.4% identity in 721 aa overlap); GLNE_HAEIN|P44419 FT Glutamate-ammonia-ligase adenylyltransferase from FT Haemophilus influenzae (981 aa), FASTA score: (28.1% FT identity in 199 aa overlap); etc. Note that initiation FT codon uncertain." FT /db_xref="GOA:P69941" FT /db_xref="InterPro:IPR013546" FT /db_xref="UniProtKB/Swiss-Prot:P69941" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD97098.1" FT /translation="MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVD FT LLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDH FT LVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAAL FT DLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGA FT RELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLES FT HIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRR FT RVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGG FT YIGREDAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRN FT DAAGVLREELKKQNVRVSKLHTKLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYE FT GPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESW FT YLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARA FT LIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQAAL FT DVMIRASLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARAVKWST FT SIAERVRALLGTPSVDPPLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLR FT AHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHTK FT LGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAADVELLRQAWLT FT ATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGEFLDNYLRVTRRAKAVVR FT KVFGS" FT CDS complement(266549..267889) FT /transl_table=11 FT /gene="glnA2" FT /locus_tag="Mb2246c" FT /product="PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE FT SYNTHASE) (GS-II)" FT /EC_number="6.3.1.2" FT /note="Mb2246c, glnA2, len: 446 aa. Equivalent to Rv2222c, FT len: 446 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 446 aa overlap). Probable glnA2, FT glutamine synthetase class II (EC 6.3.1.2), similar to FT others. Also similar to three other potential glutamine FT synthetases in Mycobacterium tuberculosis: Rv2220|glnA1, FT Rv2860c|glnA4, and Rv1878|glnA3. BELONGS TO THE GLUTAMINE FT SYNTHETASE FAMILY." FT /db_xref="GOA:P64246" FT /db_xref="HSSP:1LGR" FT /db_xref="InterPro:IPR004809" FT /db_xref="UniProtKB/Swiss-Prot:P64246" FT /protein_id="CAD97099.1" FT /translation="MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAF FT EEGIGFDGSSIEGFARVSESDTVAHPDPSTFQVLPWATSSGHHHSARMFCDITMPDGSP FT SWADPRHVLRRQLTKAGELGFSCYVHPEIEFFLLKPGPEDGSVPVPVDNAGYFDQAVHD FT SALNFRRHAIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYVIKEVA FT LEEGARASFMPKPFGQHPGSAMHTHMSLFEGDVNAFHSADDPLQLSEVGKSFIAGILEH FT ACEISAVTNQWVNSYKRLVQGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRVEVRSP FT DSACNPYLTFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRAMGYRELPSSLDSAL FT RAMEASELVAEALGEHVFDFFLRNKRTEWANYRSHVTPYELRTYLSL" FT CDS complement(267984..269546) FT /transl_table=11 FT /gene="Mb2247c" FT /locus_tag="Mb2247c" FT /product="Probable exported protease" FT /EC_number="3.4.-.-" FT /note="Mb2247c, -, len: 520 aa. Equivalent to Rv2223c, len: FT 520 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 520 aa overlap). Probable exported FT protease (EC 3.4.-.-); has signal sequence. Very similar to FT three proteases/peptidases from Streptomyces spp.: L42758, FT L42759, L27466. FASTA score: L42758|STMSLPD STMSLPD NID: FT g940302 - Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% FT identity in 533 aa overlap). Also similar to hypothetical FT proteins SW:YZZE _ECOLI P34211 (25.4% identity in 406 aa FT overlap) and PIR:B36944 in ompP 3' region (27.5% identity FT in 218 aa overlap). Highly similar to Rv2224c and Rv2672 FT (49.3% identity in 507 aa overlap); contains PS00120 FT Lipases, serine active site" FT /db_xref="GOA:P65822" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/Swiss-Prot:P65822" FT /protein_id="CAD97100.1" FT /translation="MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPG FT APVVAPQQSWNSCREFIADTSEIRTARCATVSVPVDYDQPGGTQAKLAVIRVPATGQRF FT GALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEF FT DAYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALG FT DDQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFND FT YAADCARSPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINALYS FT PQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPAD FT PAAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVST FT THDPATPYQSGVDLARQLGAPLITFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLR FT CAP" FT CDS complement(269608..271170) FT /transl_table=11 FT /gene="Mb2248c" FT /locus_tag="Mb2248c" FT /product="Probable exported protease" FT /EC_number="3.4.-.-" FT /note="Mb2248c, -, len: 520 aa. Equivalent to Rv2224c, len: FT 520 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 520 aa overlap). Probable exported FT protease (EC 3.4.-.-); has signal sequence and lipoprotein FT motif at N-terminal end. Very similar to three FT proteases/peptidases from Streptomyces spp.: L42758, FT L42759, L27466. FASTA score: L4 2758|STMSLPD STMSLPD NID: FT g940302 - Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% FT identity in 533 aa overlap). Similar to hypothetical FT protein SW:YZZE_ECOLI P34211 (27.7% identity in 412 aa FT overlap) and highly similar to Rv2224c and Rv2672 (49.3% FT identity in 507 aa overlap); contains PS00013, Prokaryotic FT membrane lipoprotein lipid attachment site, and PS00120 FT Lipases, serine active site." FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/Swiss-Prot:P65824" FT /protein_id="CAD97101.1" FT /translation="MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRARMAEPK FT LGQPVEWTPCRSSNPQVKIPGGALCGKLAVPVDYDRPDGDVAALALIRFPATGDKIGSL FT VINPGGPGESGIEAALGVFQTLPKRVHERFDLVGFDPRGVASSRPAIWCNSDADNDRLR FT AEPQVDYSREGVAHIENETKQFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALGDDKL FT TYLGYSYGTRIGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAAD FT CAKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSDAIVGTIMA FT LYSPNLWQHLTDGLSELVDNRGDTLLALADMYMRRDSHGRYNNSGDARVAINCVDQPPV FT TDRDKVIDEDRRAREIAPFMSYGKFTGDAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVV FT STTHDPATPYKAGVDLANQLRGSLLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSG FT AKC" FT |