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EBI DbfetchID BX248340; SV 1; linear; genomic DNA; STD; PRO; 291050 BP. XX AC BX248340; XX DT 10-JUN-2003 (Rel. 76, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 7/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-291050 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF00504; Glycine. XX FH Key Location/Qualifiers FH FT source 1..291050 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS complement(472..1062) FT /transl_table=11 FT /gene="Mb1729c" FT /locus_tag="Mb1729c" FT /product="Probable catechol-o-methyltransferase" FT /EC_number="2.1.1.6" FT /note="Mb1729c, -, len: 196 aa. Equivalent to Rv1703c, len: FT 196 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 196 aa overlap). Probable FT catechol-o-methyltransferase (EC 2.1.1.6), most similar to FT COMT_HUMAN|P21964 soluble form of mammalian catechol FT o-methyltransferase (271 aa), FASTA scores: opt: 405, E(): FT 7 .8e-29, (38.9% identity in 190 aa overlap). Also similar FT to Mycobacterium tuberculosis hypothetical FT methyltransferases Rv0187, Rv1220c." FT /db_xref="GOA:Q7VEU3" FT /db_xref="HSSP:1H1D" FT /db_xref="InterPro:IPR002935" FT /db_xref="UniProtKB/TrEMBL:Q7VEU3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94432.1" FT /translation="MLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYL FT GYGALRIARAAPEARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL FT TEHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMR FT RQQGMSWNTIEHKTHLEYQTLVPDLVLESEYLG" FT CDS complement(1127..2797) FT /transl_table=11 FT /gene="cycA" FT /locus_tag="Mb1730c" FT /product="PROBABLE D-SERINE/ALANINE/GLYCINE TRANSPORTER FT PROTEIN CYCA" FT /note="Mb1730c, cycA, len: 556 aa. Equivalent to Rv1704c, FT len: 556 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 556 aa overlap). Probable cycA, FT D-serine/D-alanine/glycine transporter, highly similar to FT P39312|CYCA_ECOLI d-serine/d-alanine/glycine transporter FT from Escherichia coli (470 aa), FASTA scores: opt: 1906, FT E(): 0, (59.3% identity in 459 aa overlap); etc. Also FT similar to other Mycobacterium tuberculosis amino-acid FT permeases e.g. Rv2127, Rv0346c, etc. Contains PS00218 amino FT acid permeases signature. BELONGS TO THE AMINO ACID FT PERMEASE FAMILY (APC FAMILY)." FT /db_xref="GOA:Q7TZR8" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/TrEMBL:Q7TZR8" FT /protein_id="CAD94433.1" FT /translation="MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSGR FT TISLAGPAVMVVYGIIGFFVFFVLRAMGELLLSNLNYKSFVDFAADLLGPAAGFFVGWS FT YWFAWVVTGIADLVAITGYARFWWPGLPIWVPALVTVALILAVNLFSVRHFGELEFWFA FT LIKVAAIVCLIAVGAILVATNFVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIAFFA FT YIGVELVGTAAAETADPRRTLPRAINAVPLRVAVFYIGALLAILAVVPWRQFASGESPF FT VTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTGRMLFGLADEGHAPAAFHQLNRGG FT VPAPALLLTAPLLLTSIPLLYAGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRH FT PQRHTDSVYKMPGGVVMCWAVLVFFAFVIWTLTTETETATALAWFPLWFVLLAVGWLVT FT QRRQSRRSFGFHCQVVGVRQQLGRGMARLAMKIHARPKLRSAVVVEPVSAGEPGARRSA FT KSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR" FT CDS complement(2838..3995) FT /transl_table=11 FT /gene="PPE22" FT /locus_tag="Mb1731c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1731c, PPE22, len: 385 aa. Equivalent to Rv1705c, FT len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 385 aa overlap). Member of the M. FT tuberculosis PPE family of glycine-rich proteins, similar FT to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kd protein FT cy274.2 3 (404 aa), fasta scores: opt: 819, E(): 0, (46.2% FT identity in 413 aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZR7" FT /protein_id="CAD94434.1" FT /translation="MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVAAVGY FT ERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAASQARAAAAAYETAFAAI FT VPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQYAEMWAQDAMAMYGYAGSSATATK FT VTPFAPPPNTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLPNTLLGLTSPLSSA FT LTAAATPGWLEWFINWYLPISQLFYNTVGLPYFAIGIGNSLITSWRALGWIGPEAAEAA FT AAAPAAVGAAVGGTGPVSAGLGNAATIGKLSVPPNWAGASPSLAPTVGSASAPLVSDIV FT EQPEAGAAGNLLGGMPLAGSGTGTGGAGPRYGFRVTVMSRPPFAG" FT CDS complement(4035..5219) FT /transl_table=11 FT /gene="PPE23" FT /locus_tag="Mb1732c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1732c, PPE23, len: 394 aa. Equivalent to Rv1706c, FT len: 394 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 394 aa overlap). Member of the M. FT tuberculosis PPE family of glycine-rich proteins, similar FT to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kd protein FT cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, FT (46.8% identity in 408 aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZR6" FT /protein_id="CAD94435.1" FT /translation="MTLDVPVNQGHVPPGSVACCLVGVTAVADGIAGHSLSNFGALPPE FT INSGRMYSGPGSGPLMAAAAAWDGLAAELSSAATGYGAAISELTNMRWWSGPASDSMVA FT AVLPFVGWLSTTATLAEQAAMQARAAAAAFEAAFAMTVPPPAIAANRTLLMTLVDTNWF FT GQNTPAIATTESQYAEMWAQDAAAMYGYASAAAPATVLTPFAPPPQTTNATGLVGHATA FT VAALRGQHSWAAAIPWSDIQKYWMMFLGALATAEGFIYDSGGLTLNALQFVGGMLWSTA FT LAEAGAAEAAAGAGGAAGWSAWSQLGAGPVAASATLAAKIGPMSVPPGWSAPPATPQAQ FT TVARSIPGIRSAAEAAETSVLLRGAPTPGRSRAAHMGRRYGRRLTVMADRPNVG" FT CDS complement(5823..5990) FT /transl_table=11 FT /gene="Mb1733c" FT /locus_tag="Mb1733c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1733c, -, len: 55 aa. Equivalent to Rv1706A, len: FT 55 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 55 aa overlap). Conserved hypothetical protein, FT similar to part of several probable export proteins e.g. FT Rv0783c|Z80226_28 from Mycobacterium tuberculosis (540 aa), FT FASTA scores: opt: 125, E(): 0.011, (52.85% identity in 53 FT aa overlap). Size difference suggests possible gene FT fragment." FT /db_xref="UniProtKB/TrEMBL:Q7TZR5" FT /protein_id="CAD94436.1" FT /translation="MGSLAAFKLGWLLSAMAPNVVLLTAFRVPQGLTMLTVFATGQAGQ FT HRCRTFHVTP" FT CDS 6223..7683 FT /transl_table=11 FT /gene="Mb1734" FT /locus_tag="Mb1734" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb1734, -, len: 486 aa. Equivalent to Rv1707, len: FT 486 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 486 aa overlap). Probable conserved FT transmembrane protein, possibly involved in transport of FT sulfate, similar to several hypothetical proteins belonging FT to the sulfate permease family e.g. P40877|YCHM_ECOLI FT hypothetical 58.4 kd protein in pth-prsa intergenic region FT from Escherichia coli (550 aa), FASTA scores: opt: 486, FT E(): 0, (33.1% identity in 492 aa overlap). Also similar to FT many other Mycobacterium tuberculosis membrane proteins eg. FT Rv3273, Rv1739c. SEEMS TO BELONG TO THE SULP FAMILY." FT /db_xref="GOA:Q7TZR4" FT /db_xref="InterPro:IPR011547" FT /db_xref="UniProtKB/TrEMBL:Q7TZR4" FT /protein_id="CAD94437.1" FT /translation="MLQRIARELLSGVAVAIVALPLAIAFGITATGTSQGALIGLYGAI FT FAGFFAAVFGGTPGQVTGPTGPITVVATATIAEHGLEGAFFAFILAGVFQILFGACRLG FT SLIRYVPHPVISGFMGGIAILIIMTQLDQVRSSSLLVLVTVVLLLASGRFIKAIPPSLL FT VLVLVSSVLPLAAPWLRDLRAGPVSINRTVDYIGEIPQAMPSFDFPQVANSTMLQVLLS FT AVAIALLGSLDSLLTSLVMDNIRGTRHRSNKELIGQGIGNIAAGLFGGLAGAGATVRSV FT VNVRNGGQTALSAATHSVVLFVFVAGLGAVVQYIPLAVLSGILILVAVGMFDWHAMRKA FT HVSPRGDVIVMFTTMIITVVVDLTIAVMVGIALSLLVHRLRSRQRKAKVTQDDTGTYRI FT DGPLSFLSVDGVFGSLRDGREDVSLDLQHVTYLDTSGAQALLYFIDHSEKDGVAVSIKR FT IPPRLESQLTALADNEQRDKLRTVLESA" FT CDS 7701..8657 FT /transl_table=11 FT /gene="Mb1735" FT /locus_tag="Mb1735" FT /product="PUTATIVE INITIATION INHIBITOR PROTEIN" FT /note="Mb1735, -, len: 318 aa. Equivalent to Rv1708, len: FT 318 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 318 aa overlap). Putative initiation FT inhibitor protein, a soj-related protein probably involved FT in cell process, highly similar to many sporulation FT initiation inhibitor proteins soj e.g. P37522|SOJ_BACSU Soj FT protein from Bacillus subtilis (253 aa), FASTA scores: opt: FT 745, E(): 0, (46.0% identity in 248 aa overlap), and more FT weakly to various repA/para/incC proteins from various FT organisms e.g. Y4CK_RHISN|P55393 putative replication FT protein A from Rhizobium sp. (407 aa), FASTA scores: opt: FT 205, E(): 4e-13, (29.0% identity in 252 aa overlap). Also FT similar to Mycobacterium tuberculosis hyothetical proteins FT Rv3213c and Rv3918c." FT /db_xref="GOA:Q7TZR3" FT /db_xref="HSSP:1IHU" FT /db_xref="InterPro:IPR002586" FT /db_xref="UniProtKB/TrEMBL:Q7TZR3" FT /protein_id="CAD94438.1" FT /translation="MPAGLPGQASVAVRLSCDVPPDARHHEPRPGMTDHPDTGNGIGLT FT GRPPRAIPDPTPRSSHGPAKVIAMCNQKGGVGKTTSTINLGAALGEYGRRVLLVDMDPQ FT GALSAGLGVPHYELDKTIHNVLVEPRVSIDDVLIHSRVKNMDLVPSNIDLSAAEIQLVN FT EVGREQTLARALYPVLDRYDYVLIDCQPSLGLLTVNGLACTDGVIIPTECEFFSLRGLA FT LLTDTVDKVRDRLNPKLDISGILITRYDPRTVNSREVMARVVERFGDLVFDTVITRTVR FT FPETSVAGEPITTWAPKSAGALAYRALARELIDRFGM" FT CDS 8654..9490 FT /transl_table=11 FT /gene="Mb1736" FT /locus_tag="Mb1736" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1736, -, len: 278 aa. Equivalent to Rv1709, len: FT 278 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 278 aa overlap). Conserved hypothetical FT protein, similar to others e.g. P35154|YPUG_BACSU from FT Bacillus subtilis (251 aa), FASTA scores: opt: 271, E(): FT 8.2e-10, (27.0% identity in 248 aa overlap); FT Q9S230|SCI51.10C|AL109848 from Streptomyces coelicolor (264 FT aa), FASTA scores: opt: 855, E(): 0, (56.8% identity in 257 FT aa overlap). Equivalent to Q49888|MLC1351.05C|Z95117 from FT Mycobacterium leprae (268 aa), FASTA scores: (78.9% FT identity in 251 aa overlap)." FT /db_xref="GOA:Q7TZR2" FT /db_xref="InterPro:IPR003768" FT /db_xref="UniProtKB/TrEMBL:Q7TZR2" FT /protein_id="CAD94439.1" FT /translation="MNGLQNSLANGGTAPENGYSAGFRVRLTNFEGPFDLLLQLIFAHQ FT LDVTEVALHQVTDDFIAYTKAIGARLELEETTAFLVIAATLLDLKAARLLPAGQVDDEE FT DLALLEVRDLLFARLLQYRAFKHVAEMFAELEATALRSYPRAVSLEDGFVGLLPEVMLG FT VDAHRFAEIAAIALTPRPAPTVATEHLHELMVSVPEQAEHLLAMLKARGSGQWASFSEL FT VADCTAPIEIVGRFLALLELYRTRAVAFEQSEPLGALQVSWTGDDAERSDEKERRL" FT CDS 9487..10182 FT /transl_table=11 FT /gene="Mb1737" FT /locus_tag="Mb1737" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1737, -, len: 231 aa. Equivalent to Rv1710, len: FT 231 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 231 aa overlap). Conserved hypothetical FT protein, similar to several hypothetical proteins e.g. FT P35155|YPUH_BACSU from Bacillus subtilis (197 aa), FASTA FT scores: opt: 339, E(): 1.3e-09, (36.0% identity in 186 aa FT overlap); Q9S231|SCI51.09C|AL109848 from Streptomyces FT coelicolor (223 aa), FASTA scores: opt: 626, E(): 0, (51.0% FT identity in 192 aa overlap). Equivalent to FT O05669|MLC1351.04C|Z95117 Hypothetical protein from FT Mycobacterium leprae (231 aa), FASTA scores: (77.9% FT identity in 231 aa overlap)." FT /db_xref="GOA:Q7TZR1" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7TZR1" FT /protein_id="CAD94440.1" FT /translation="MTEHMPEHDPSYGIPDIAEPAELDADELKRVLEALLLVIDTPVTA FT DALAAATEQPVYRVAAKLQLMADELTGRDSGIDLRHTSEGWRMYTRARFAPYVEKLLLD FT GARTKLTRAALETLAVVAYRQPVTRARVSAVRGVNVDAVMRTLLARGLITEVGTDADTG FT AVTFATTELFLERLGLTSLSELPDIAPLLPDVDTIDDLSESLDSEPRFIKLTGELASEQ FT TLSFDVDRD" FT CDS 10179..10943 FT /transl_table=11 FT /gene="Mb1738" FT /locus_tag="Mb1738" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1738, -, len: 254 aa. Equivalent to Rv1711, len: FT 254 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 254 aa overlap). Conserved hypothetical FT protein, highly similar to a large family of hypothetical FT proteins e.g. P37765|YCIL_ECOLI from Escherichia coli (291 FT aa), FASTA scores: opt: 496, E(): 1.1e-29, (41.6% identity FT in 250 aa overlap); 9S232|SCI51.08C|AL109848 PUTATIVE FT PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (371 FT aa), FASTA scores: opt: 818, E(): 0, (53.1% identity in 245 FT aa overlap). Equivalent to O05668|MLCB1351.03C|Z95117 FT Hypothetical protein from Mycobacterium leprae (256 aa), FT (80.5% identity in 256 aa overlap). Contains PS01149 FT Hypothetical yciL/yejD/yjbC family signature." FT /db_xref="GOA:P65843" FT /db_xref="HSSP:1KSK" FT /db_xref="InterPro:IPR002942" FT /db_xref="UniProtKB/Swiss-Prot:P65843" FT /protein_id="CAD94441.1" FT /translation="MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDGH FT VVTELGTRVDPQVAVVRVDGARVVLDDSLVYLALNKPRGMHSTMSDDRGRPCIGDLIER FT KVRGTKKLFHVGRLDADTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRGLGR FT TLRAGIELDDGPAFVDDFAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEALVRT FT DIGAVSLGKQRPGSVRALRSNEIGQLYQAVGL" FT CDS 10940..11632 FT /transl_table=11 FT /gene="cmk" FT /locus_tag="Mb1739" FT /product="Probable Cytidylate kinase cmk (CMP kinase) FT (Cytidine monophosphate kinase) (CK)" FT /EC_number="2.7.4.14" FT /note="Mb1739, cmk, len: 230 aa. Equivalent to Rv1712, len: FT 230 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 230 aa overlap). Probable cmk, cytidylate FT kinase (EC 2.7.4.14), highly similar to many e.g. FT KCY_ECOLI|P23863 cytidylate kinase from Escherichia coli FT (227 aa), FASTA scores: opt: 534, E (): 0, (40.3% identity FT in 221 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). Equivalent to Z95117|MLCB1351_2 from FT Mycobacterium leprae (223 aa) (73.5% identity in 226 aa FT overlap). BELONGS TO THE CYTIDYLATE KINASE FAMILY, FT SUBFAMILY 1." FT /db_xref="GOA:P63804" FT /db_xref="HSSP:1CKE" FT /db_xref="InterPro:IPR011994" FT /db_xref="UniProtKB/Swiss-Prot:P63804" FT /protein_id="CAD94442.1" FT /translation="MSRLSAAVVAIDGPAGTGKSSVSRRLARELGARFLDTGAMYRIVT FT LAVLRAGADPSDIAAVETIASTVQMSLGYDPDGDSCYLAGEDVSVEIRGDAVTRAVSAV FT SSVPAVRTRLVELQRTMAEGPGSIVVEGRDIGTVVFPDAPVKIFLTASAETRARRRNAQ FT NVAAGLADDYDGVLADVRRRDHLDSTRAVSPLQAAGDAVIVDTSDMTEAEVVAHLLELV FT TRRSEAVR" FT CDS 11629..13020 FT /transl_table=11 FT /gene="engA" FT /locus_tag="Mb1740" FT /product="PROBABLE GTP-BINDING PROTEIN ENGA" FT /note="Mb1740, engA, len: 463 aa. Equivalent to Rv1713, FT len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 463 aa overlap). Probable engA, FT GTP-binding protein. Equivalent to FT Q49884|MLCB1351.01|U00021_5 PROBABLE GTP-BINDING PROTEIN FT ENGA from Mycobacterium leprae (461 aa), (88.6% identity in FT 463 aa overlap). And similar to many e.g. P50743|ENGA_BACSU FT PROBABLE GTP-BINDING PROTEIN ENGA from Bacillus subtilus FT (436 aa), FASTA scores: opt: 1077, E(): 0, (40.6% identity FT in 434 aa overlap). Contains two PS00017 ATP/GTP-binding FT site motif A (P-loop). BELONGS TO THE ERA/TRME FAMILY OF FT GTP-BINDING PROTEINS. ENGA SUBFAMILY." FT /db_xref="GOA:P64058" FT /db_xref="HSSP:1MKY" FT /db_xref="InterPro:IPR005225" FT /db_xref="UniProtKB/Swiss-Prot:P64058" FT /protein_id="CAD94443.1" FT /translation="MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNR FT ILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMR FT TADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGE FT PHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGD FT QRSVVHEAAGTTVDPVDSLIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDS FT AEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELV FT QVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGG FT KQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKR FT AGKRR" FT CDS 13194..14006 FT /transl_table=11 FT /gene="Mb1741" FT /locus_tag="Mb1741" FT /product="Probable oxidoreductase" FT /EC_number="1.-.-.-" FT /note="Mb1741, -, len: 270 aa. Equivalent to Rv1714, len: FT 270 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 270 aa overlap). Probable oxidoreductase (EC FT 1.-.-.-) similar to many e.g. AE0010|AE001021_4 FT Archaeoglobus fulgidus section 79 (281 aa), FASTA scores: FT opt: 578, E(): 3.3e-31, (38.9% identity in 265 aa overlap). FT Also similar to several other Mycobacterium tuberculosis FT oxidoreductases e.g. Rv1544, etc." FT /db_xref="GOA:Q7VEU2" FT /db_xref="HSSP:1H5Q" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7VEU2" FT /protein_id="CAD94444.1" FT /translation="MEEMALAQQVPNLGLARFSVQDKSILITGATGSLGRVAARALADA FT GARLTLAGGNSAGLAELVNGAGIDDAAVVTCRPDSLADAQQMVEAALGRYGRLDGVLVA FT SGSNHVAPITEMAVEDFDAVMDANVRGAWLVCRAAGRVLLEQGQGGSVVLVSSVRGGLG FT NAAGYSAYCPSKAGTDLLAKTLAAEWGGHGIRVNALAPTVFRSAVTEWMFTDDPKGRAT FT REAMLARIPLRRFAEPEDFVGALIYLLSDASSFYTGQVMYLDGGYTAC" FT CDS 14000..14563 FT /transl_table=11 FT /gene="fadB3a" FT /locus_tag="Mb1742" FT /product="PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE FT FADB3a [FIRST PART] (BETA-HYDROXYBUTYRYL-COA DEHYDROGENASE) FT (BHBD)" FT /EC_number="1.1.1.157" FT /note="Mb1742, fadB3a, len: 187 aa. Equivalent to the 5' FT end of Rv1715, len: 304 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 187 aa overlap). Probable FT fadB3, 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), FT highly similar to many e.g. NP_107236.1|NC_002678 FT 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti FT (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA FT dehydrogenase from Pseudomonas aeruginosa (509 aa); FT P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA FT DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA FT scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa FT overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA FT DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1715/fadB3 FT exists as a single gene. In Mycobacterium bovis, a single FT base transition (g-a) splits fadB3 into 2 parts, fadB3a and FT fadB3b." FT /db_xref="GOA:Q7TZR0" FT /db_xref="HSSP:1F0Y" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZR0" FT /protein_id="CAD94445.1" FT /translation="MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHA FT AAVEAARVAGAGRGSVAAAADLAAAIPDADLVIEAVVENLAVKQELFERLATLAPDAVL FT ATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQ FT VGKLPVRVGRDVPGFIGNRLQHAL" FT CDS 14621..14914 FT /transl_table=11 FT /gene="fadB3b" FT /locus_tag="Mb1743" FT /product="PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE FT FADB3b [SECOND PART] (BETA-HYDROXYBUTYRYL-COA FT DEHYDROGENASE) (BHBD)" FT /EC_number="1.1.1.157" FT /note="Mb1743, fadB3b, len: 97 aa. Equivalent to the 3' end FT of Rv1715, len: 304 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 97 aa overlap). Probable FT fadB3, 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), FT highly similar to many e.g. NP_107236.1|NC_002678 FT 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti FT (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA FT dehydrogenase from Pseudomonas aeruginosa (509 aa); FT P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA FT DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA FT scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa FT overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA FT DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1715/fadB3 FT exists as a single gene. In Mycobacterium bovis, a single FT base transition (g-a) splits fadB3 into 2 parts, fadB3a and FT fadB3b." FT /db_xref="GOA:Q7TZQ9" FT /db_xref="HSSP:1F0Y" FT /db_xref="InterPro:IPR013328" FT /db_xref="UniProtKB/TrEMBL:Q7TZQ9" FT /protein_id="CAD94446.1" FT /translation="MVRNTIGLRLATLGPLENADYIGLDLTLAIHDAVIPSLNHDPHPS FT PLLRELVAAGQLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEKGRGT" FT CDS 14917..15747 FT /transl_table=11 FT /gene="Mb1744" FT /locus_tag="Mb1744" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1744, -, len: 276 aa. Equivalent to Rv1716, len: FT 276 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 276 aa overlap). Conserved hypothetical FT protein, shows high similarity with FT AF1200|O29068|AE001021_11A conserved protein of FT Archaeoglobus fulgidus, gp fulgidus section 7 (278 aa), FT FASTA scores: E(): 0, (61.8% identity in 251 a a overlap); FT also weak similarity to several polyketide cyclases e.g. FT O68500|AF048833|DPSY from Streptomyces peucetius (272 aa), FT FASTA scores: opt: 194, E(): 1.7e-05, (29.6% identity in FT 223 aa overlap)." FT /db_xref="InterPro:IPR007325" FT /db_xref="UniProtKB/TrEMBL:Q7TZQ8" FT /protein_id="CAD94447.1" FT /translation="MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMA FT KSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTA FT EDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDT FT QALDHPLATAIAPHGPAEAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIY FT GFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAA" FT CDS 15747..16097 FT /transl_table=11 FT /gene="Mb1745" FT /locus_tag="Mb1745" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1745, -, len: 116 aa. Equivalent to Rv1717, len: FT 116 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 116 aa overlap). Conserved hypothetical FT protein, similar to O29060|AF1208|AE001021 Hypothetical FT protein from Arecheoglobus fulgidus (114 aa), FASTA scores: FT opt: 254, E(): 3.3e-09, (37.7% identity in 114 aa FT overlap)." FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:Q7TZQ7" FT /protein_id="CAD94448.1" FT /translation="MKLTRASQAPRYVAPAHHEVSTMRLQGREAGRTERFWVGLSVYRP FT GGTAEPAPTREETVYVVLDGELVVTVDGAETVLGWLDSVHLAKGELRSIHNRTDRQALL FT LVTVAHPVAEVA" FT CDS 16150..16773 FT /transl_table=11 FT /gene="Mb1746" FT /locus_tag="Mb1746" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1746, -, len: 207 aa. Equivalent to the 5' end of FT Rv1718, len: 272 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100% identity in 193 aa overlap). Conserved FT hypothetical protein, similar to O29058|AF1210|AE001021 FT Hypothetical protein from Archeoglobus (313 aa), FASTA FT scores: opt: 301, E(): 8e-23, (31.6% identity in 301 aa FT overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1718 exists as a single gene. FT In Mycobacterium bovis, a single base deletion (c-*) leads FT to a shorter product with a different COOH terminus." FT /db_xref="InterPro:IPR008567" FT /db_xref="UniProtKB/TrEMBL:Q7TZQ6" FT /protein_id="CAD94449.1" FT /translation="MSIVITVAPTGPIATKADNPALPTSPEEIATAVEQAYHAGAAVAH FT IHLRDENERPTADPNIARRAMDLIGERCPILIQLSTGVGLTVPFEQREQLVELRPRMAT FT LNPCSMSFGAGEFRNPPQAVRRLAARMRELDIKPELEIYDTGHLEACLRLWAEDLLAEP FT LQFSIVLGVRGGMAATADNLLTMVRRLPPGRSGKSSRSVRPTWN" FT CDS 16981..17760 FT /transl_table=11 FT /gene="Mb1748" FT /locus_tag="Mb1748" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1748, -, len: 259 aa. Equivalent to Rv1719, len: FT 259 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 259 aa overlap). Probable transcriptional FT regulatory protein, similar to YIAJ_ECOLI|P37671 FT hypothetical transcriptional regulator from Escherichia FT coli (282 aa), FASTA scores: opt: 353, E(): 3.2e-15, (31.1% FT identity in 235 aa overlap). Similar to Mycobacterium FT tuberculosis hypothetical IclR-family transcriptional FT regulators Rv2989, Rv1773c. Helix-turn-helix motif from aa FT 34-55 (+6.94 SD)." FT /db_xref="GOA:Q7TZQ5" FT /db_xref="HSSP:1HW5" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7TZQ5" FT /protein_id="CAD94450.1" FT /translation="MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQAEIGERVGMA FT RSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVRLGVVTEMHPFLTELSRELD FT ETVDLSILDGDRADVVDQVVPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQARAL FT PSRLAPLTANTITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLRGVSVELVAVS FT VPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK" FT tRNA 17953..18026 FT /gene="proT" FT /locus_tag="proT" FT /note="proT, len: 74 nt. Equivalent to proT, len: 74 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 74 nt overlap). tRNA-Pro, anticodon ggg." FT repeat_region 18189..18363 FT /mobile_element="insertion sequence:IS1540" FT /locus_tag="IS1540'-1" FT /note="IS1540'-1, len: 175 nt. Equivalent to a region of FT IS1540, len: 1163 nt, from Mycobacterium tuberculosis FT strain H37Rv, (97.7% identity in 176 nt overlap)." FT CDS complement(18370..18759) FT /transl_table=11 FT /gene="Mb1749c" FT /locus_tag="Mb1749c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1749c, -, len: 129 aa. Equivalent to Rv1720c, len: FT 129 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 129 aa overlap). Conserved hypothetical FT protein, similar to other Mycobacterium tuberculosis FT hypothetical proteins e.g. O53610|Rv0065|MTV030.08 (133 FT aa), FASTA scores: E(): 1.5e-10, (39.1% identity in 128 aa FT overlap); P71550|Rv0960|MTCY10D7.14C (129 aa) and FT O06415|Rv0549c|MTCY25D10.28C (137 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7TZQ4" FT /protein_id="CAD94451.1" FT /translation="MIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAI FT RQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFTQRAYQLRSTHTVADGAYVALAEGL FT GVPLITCDGRLAQSHGHNAEIELVA" FT CDS complement(18756..18983) FT /transl_table=11 FT /gene="Mb1750c" FT /locus_tag="Mb1750c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1750c, -, len: 75 aa. Equivalent to Rv1721c, len: FT 75 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 75 aa overlap). Conserved hypothetical protein, FT similar to Rv0300|MTCY63.05|O07227 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (73 aa). Start FT changed since original submission." FT /db_xref="UniProtKB/TrEMBL:Q7TZQ3" FT /protein_id="CAD94452.1" FT /translation="MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPA FT LDDVLDRLAALPRRDLGASAAELVDEARSE" FT CDS 19201..20685 FT /transl_table=11 FT /gene="Mb1751" FT /locus_tag="Mb1751" FT /product="POSSIBLE CARBOXYLASE" FT /note="Mb1751, -, len: 494 aa. Equivalent to Rv1722, len: FT 494 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 494 aa overlap). Possible carboxylases. FT Weak similarity to several e.g. ACCC_BACSU|P49787 biotin FT carboxylase from Bacillus subtilis (448 aa), fasta scores: FT opt: 171, E(): 0.00021, (22.8% identity in 237 aa FT overlap)." FT /db_xref="GOA:Q7TZQ2" FT /db_xref="InterPro:IPR011761" FT /db_xref="UniProtKB/TrEMBL:Q7TZQ2" FT /protein_id="CAD94453.1" FT /translation="MIVPAREPEPQPRRVLNGLSDVRAFFHNNTMPLYFISPTPFNLLG FT IYRWIRNFFYLTYYDSFEGEHSRVFVPRRRDRRDFDGMGDVCNHLLRDPETLEFIKNRG FT PGGKACFVMLDEETQALARQAGLEVMHPPAELRHRLESKIVMTRLADEAGVPSVPHVIG FT RVSSYDELSALAHGAGLGDDLVVEAAYGNAGSATFFVRGLRDWDQCAGGIVGQPEIKVM FT KRIRNVEVCIEATVTRHGTVIGPAMTSLVGYPELTPYRGAWCGNDVWRGALPPAQTRAA FT REMVAKLGDVLSREGYRGYFEVDLLHDLDADELYLGEVNPRLSGASPMTNLTTEAYADM FT PLFLFHLLEYMDVDYELDIEAINSRWERGYGEDEVWGQLIMSETSPDLELFTATPRTGM FT WRLNHDGRVSFARQGNDWATMLDESEAFYMRVAAPGDLRCEGAQLGVLVTRGHLQTDDY FT QLTERGRRWIDGLKAQFASTPLTPAAPIVSRLVARA" FT CDS 20682..21929 FT /transl_table=11 FT /gene="Mb1752" FT /locus_tag="Mb1752" FT /product="PROBABLE HYDROLASE" FT /EC_number="3.-.-.-" FT /note="Mb1752, -, len: 415 aa. Equivalent to Rv1723, len: FT 415 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 415 aa overlap). Possible hydrolase (EC FT 3.-.-.-), similar to others e.g. NYLB_FLASP|P07061 FT 6-aminohexanoate-dimer hydrolase from Flavobacterium sp. FT (392 aa), FASTA scores: opt: 717, E(): 0, (35.1% identity FT in 396 aa overlap). Also similar to Mycobacterium FT tuberculosis hypothetical esterases and penicillin binding FT proteins e.g. Rv1923, Rv1497, Rv2463, etc." FT /db_xref="GOA:Q7TZQ1" FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q7TZQ1" FT /protein_id="CAD94454.1" FT /translation="MSGGVPAGLALDNWLSSPYSHWAFQHVEDFMPTTVIARGTEPVVT FT LPADNAPIADIGLTSTDGIATTVGAVMAATATDGWAVAHRGALVAEQYLDGLGPRTRHL FT LFSVSKSLVAAVVGALHGAGAIELDAPVTAYVPALADCGYAGATVRHLLDMRSGVAFSE FT NYDDPAAEIHVREQVIGWAPKRGPDLPATLRDYLLTLRRKSAHGGPFEYRSCETDVLGW FT ICEAAAGQPMPELMSELLWSRIGAQCDATIALDVAGAAGTGIFDGGISACLTDMIRFGS FT LYLRDGVSLAGQQVVPAAWIADTFDGGPDSRQAFAASPDDNPMPGGMYRNQVWFPYPGS FT NVALCVGMCGQLIYVNRAAEVVAAKLSTQPHSHEPHMLDTLRAFDAVAHELSGIRSSST FT NDPQRPSPPAQEASPG" FT CDS complement(21972..22391) FT /transl_table=11 FT /gene="Mb1753c" FT /locus_tag="Mb1753c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1753c, -, len: 139 aa. Equivalent to Rv1724c, len: FT 139 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 139 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZQ0" FT /protein_id="CAD94455.1" FT /translation="MVGNEENELQDLRNLRRPCFSRAEAPIGVYNGEQAIIVYDLRPVP FT HWPKYWIQALAKHFQRQLKPSPKIDISLLDDRIRFSVFVSTDVSAKDLCKLDDAVYNAV FT RNAGRAIENEQAALDHKLAEVRKRRMDTWDESYFR" FT CDS complement(22381..23091) FT /transl_table=11 FT /gene="Mb1754c" FT /locus_tag="Mb1754c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1754c, -, len: 236 aa. Equivalent to Rv1725c, len: FT 236 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 236 aa overlap). Conserved hypothetical FT protein, similar to other hypothetical proteins from FT diverse organisms e.g. P70885|U44893 ORF108 from FT BUTYRIVIBRIO FIBRISOLVENS, (108 aa), FASTA scores: opt: FT 223, E(): 2e-09, (39.1% identity in 92 aa overlap). Also FT similar to Mycobacterium tuberculosis hypothetical FT transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158 FT aa)." FT /db_xref="InterPro:IPR002577" FT /db_xref="UniProtKB/TrEMBL:Q7TZP9" FT /protein_id="CAD94456.1" FT /translation="MQPYGQYCPVARAAELLGDRWTLLIVRELLFGPLRFTEIERGLPG FT ISRSVLAQRLRRLQHDRIIEAVPEHTGGGYRFTVAGEELRPVLQTLGDWVSRWLMADPT FT PAECDPELLTLWISRRVNTEALPGRRVVVEFRYHGERPLWAWLVLEPGDISVCLHDPCL FT PVDLTVRGHPRDLYRVYSGRSTLAAEISAERIELDGLPAMRRAFPSWMAWSPFAPAMRQ FT AVVSVDQMPEAHGG" FT CDS 23192..24577 FT /transl_table=11 FT /gene="Mb1755" FT /locus_tag="Mb1755" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1755, -, len: 461 aa. Equivalent to Rv1726, len: FT 461 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 461 aa overlap). Probable oxidoreductase FT (EC 1.-.-.-), similar to HDNO_ARTOX|P08159 FT 6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt: FT 678, E(): 0, (29.5% identity in 465 aa overlap). Also FT similar to Mycobacterium tuberculosis hypothetical FT dehydrogenases e.g. Rv3107c, Rv1257c, etc." FT /db_xref="GOA:Q7TZP8" FT /db_xref="InterPro:IPR002114" FT /db_xref="UniProtKB/TrEMBL:Q7TZP8" FT /protein_id="CAD94457.1" FT /translation="MTATLTKTLGSLDDFRGTLCVPGDPDYPRVRAIWNGQVAREPALI FT ATCHDACDVRTVLRRPVDAGMVTAVRGGGHNVAGTALCDGGVVIDLSAMRAVSLDPATG FT RVRVQGGATLADLDHATVPFARVAPAGIVTTTGVGGLTLGGGVGWTTRRFGLSCDNLVA FT VRLVTAAGDYLSVDDERDPELMWGLRGGGGNFGIVTEFEFATHPFGPVAVAGFVVYRLD FT DGPAVLRGYRQFAAAAPEEVTTIVVLRHAPPAPWIPVDQRGKPVVMIGAVHTGSIQTGI FT EALRPVKSLARPVADTVWPTPFLAHQAVLDASNPAGHRYYWKSDYLAELNDEAIDLLVE FT QTAQLSSPDSLIGIFQLGGAAARGGERSCFPSRHARFMVNYATHWTEAREDDLHRQWTR FT DAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLKNRLDPDNVFRNNHNIR FT PSA" FT CDS 24610..25179 FT /transl_table=11 FT /gene="Mb1756" FT /locus_tag="Mb1756" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1756, -, len: 189 aa. Equivalent to Rv1727, len: FT 189 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 189 aa overlap). Similar to Mycobacterium FT tuberculosis hypothetical proteins FT P72040|Rv3773c|MTCY13D12.07C (194 aa), FASTA scores: opt: FT 176, E(): 2.7e-08, (31.1% identity in 180 aa overlap); and FT O53801|Rv0738 (182 aa)." FT /db_xref="InterPro:IPR017520" FT /db_xref="UniProtKB/TrEMBL:Q7TZP7" FT /protein_id="CAD94458.1" FT /translation="MDLYSNLVEAEQRLVALVSSIEADSYSSPTPCDRWDVRALLSHAL FT ASIDAFAAAVDGAPGPDMAQVFSGADIVGDDPLGATQRITRRSQAAWSTVRDLNAELST FT FIGVMPAGQALAIITFSTVVHGWDLAVATGQAGELPEHLAEAAQQVAAELVPVLRPRGL FT FAHDVDLAGEATPTQRLVALTGRKPR" FT CDS complement(25204..25974) FT /transl_table=11 FT /gene="Mb1757c" FT /locus_tag="Mb1757c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1757c, -, len: 256 aa. Equivalent to Rv1728c, len: FT 256 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 256 aa overlap). Conserved hypothetical FT protein, some similarity to O07246|Rv0320|MTCY63.25 FT possible exported protein from Mycobacterium tuberculosis FT (220 aa), FASTA scores: E(): 1.3e-31, (42.3% identity in FT 220 aa overlap). C-terminal region similar to FT Q9ZX60|AF068845|AF068845_17 segment of gp17 of FT Mycobacteriophage TM4 (1229 aa), FASTA scores: opt: 385, FT E(): 4.3e-17, (44.6% identity in 139 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZP6" FT /protein_id="CAD94459.1" FT /translation="MSVNGLPGAHNAGLQPIDSKGCHTRRTRHTKVLFVSKGVLANGRG FT RWLAIAASLVVSAAILYAQGAEHTCCRETPAAIPTGPDSAPANAPRIASPTEADLLAAS FT APVAAQQFQFALPAGVASEEGLQVKTIWVARAVSVLFPQITNIFGYRQDPLKWHPNGLA FT IDVMIPNHHSDEGIQLGNQVAGLALANAKRWGVLHVIWRQGYYPGIGAPSWTADYGSET FT LNHYDHVHIATDGGGYPTGRETYYVGSMSPTPPE" FT CDS complement(25971..26909) FT /transl_table=11 FT /gene="Mb1758c" FT /locus_tag="Mb1758c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1758c, -, len: 312 aa. Equivalent to Rv1729c, len: FT 312 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 312 aa overlap). Conserved hypothetical FT protein, similar to many Mycobacterium tuberculosis FT hypothetical proteins e.g. Q50726|Rv3399|YX99_MYCTU (348 FT aa), FASTA scores: opt: 1019, E(): 0, (55.7% identity in FT 296 aa overlap); P95074|Rv0726c (367 aa), O53795|Rv0731c FT (318 aa), and O53841|Rv0830 (301 aa), etc." FT /db_xref="GOA:Q7TZP5" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/Swiss-Prot:Q7TZP5" FT /protein_id="CAD94460.1" FT /translation="MARTDDDNWDLTSSVGVTATIVAVGRALATKDPRGLINDPFAEPL FT VRAVGLDLFTKMMDGELDMSTIADVSPAVAQAMVYGNAVRTKYFDDYLLNATAGGIRQV FT AILASGLDSRAYRLPWPTRTVVYEIDQPKVMEFKTTTLADLGAEPSAIRRAVPIDLRAD FT WPTALQAAGFDSAAPTAWLAEGLLIYLKPQTQDRLFDNITALSAPGSMVATEFVTGIAD FT FSAERARTISNPFRCHGVDVDLASLVYTGPRNHVLDYLAAKGWQPEGVSLAELFRRSGL FT DVRAADDDTIFISGCLTDHSSISPPTAAGWR" FT CDS complement(27089..28642) FT /transl_table=11 FT /gene="Mb1759c" FT /locus_tag="Mb1759c" FT /product="POSSIBLE PENICILLIN-BINDING PROTEIN" FT /note="Mb1759c, -, len: 517 aa. Equivalent to Rv1730c, len: FT 517 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 517 aa overlap). Possible penicillin-binding FT protein, similar to others e.g. PBP4_NOCLA|Q06317 FT penicillin-binding protein 4 (pbp-4) from Nocardia FT lactamdurans (381 aa), FASTA scores: opt: 643, E(): FT 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also FT similar to other Mycobacterium tuberculosis hypothetical FT penicillin binding proteins and esterases e.g. Rv1923, FT Rv1497, etc." FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q7TZP4" FT /protein_id="CAD94461.1" FT /translation="MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVV FT ETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDG FT DTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNH FT TAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGT FT TYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTG FT GLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWM FT LRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQR FT FAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDD FT ANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ FT " FT CDS 29074..30630 FT /transl_table=11 FT /gene="gabD2" FT /locus_tag="Mb1760" FT /standard_name="gabD1" FT /product="POSSIBLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE FT [NADP+] DEPENDANT (SSDH) GABD2" FT /EC_number="1.2.1.16" FT /note="Mb1760, gabD2, len: 518 aa. Equivalent to Rv1731, FT len: 518 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 518 aa overlap). Possible gabD2, FT succinate-semialdehyde dehydrogenase [NADP+] dependent (EC FT 1.2.1.16), similar to others e.g. GABD_ECOLI|P25526 FT succinate-semialdehyde dehydrogenase from Escherichia coli FT (482 aa), FASTA scores: opt: 870, E(): 0, (34.7% identity FT in 449 aa overlap); etc. Also similar to FT gabD1|Rv0234c|MTCY08D5.30c PROBABLE SUCCINATE-SEMIALDEHYDE FT DEHYDROGENASE [NADP+] DEPENDANT from Mycobacterium FT tuberculosis (511 aa); and other semialdehyde FT dehydrogenases e.g. Rv0768|aldA (489 aa), Rv2858c|aldC (455 FT aa), etc. Contains PS00216 Sugar transport proteins FT signature 1, PS00687 Aldehyde dehydrogenases glutamic acid FT active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. FT Note that previously known as gabD1." FT /db_xref="GOA:Q7TZP3" FT /db_xref="HSSP:1BXS" FT /db_xref="InterPro:IPR015590" FT /db_xref="UniProtKB/Swiss-Prot:Q7TZP3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94462.1" FT /translation="MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGT FT AADVEAAFAEARAAQTDWAKRPVIERAAVIRRYRDLVIENREFLMDLLQAEAGKARWAA FT QEEIVDLIANANYYARVCVDLLKPRKAQPLLPGIGKTTVCYQPKGVVGVISPWNYPMTL FT TVSDSVPALVAGNAVVLKPDSQTPYCALACAELLYRAGLPRALYAIVPGPGSVVGTAIT FT DNCDYLMFTGSSATGSRLAEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACF FT SNAGQLCISIERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVS FT GHVDDATAKGAKVIAGGKARPDIGPLFYEPTVLTNVAPEMECAANETFGPVVSIYPVAD FT VDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGTVNVDEGYAFAWGSLSAPMGGM FT GLSGVGRRHGPEGLLKYTESQTIATARVFNLDPPFGIPATVWQKSLLPIVRTVMKLPGR FT R" FT CDS complement(30640..31188) FT /transl_table=11 FT /gene="Mb1761c" FT /locus_tag="Mb1761c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1761c, -, len: 182 aa. Equivalent to Rv1732c, len: FT 182 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 182 aa overlap). Conserved hypothetical FT protein, highly similar to hypothetical proteins from FT several organisms e.g. P73178|SLL1289|D90904 from FT Synechocystis (194 aa), FASTA scores: opt: 663, E(): 0, FT (53.1% identity in 179 aa overlap); etc." FT /db_xref="GOA:Q7TZP2" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/TrEMBL:Q7TZP2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94463.1" FT /translation="MAVESSMLALGTPAPSFTLPQPATGATVSLDELTGPALVVTFICN FT HCPYVQHVAAGLATLGRDLADQGVPMVGISSNDVVTYPQDGPDQMVAEARRHGWTFPYL FT YDETQDVARAFSAACTPDTFVFDGQRRLVYRGQLDDSRPGNGRPVTAADVRAAVDALLA FT GRPVNPDQRPSIGCGIKWR" FT CDS complement(31252..31884) FT /transl_table=11 FT /gene="Mb1762c" FT /locus_tag="Mb1762c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb1762c, -, len: 210 aa. Equivalent to Rv1733c, len: FT 210 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 210 aa overlap). Probable conserved FT transmembrane protein. Similar to AL109962|SCJ1_26 FT hypothetical protein from Streptomyces coelicolor (193 aa), FT FASTA scores: opt: 287, E(): 3.8e-11, (35.2% identity in FT 182 aa overlap)." FT /db_xref="GOA:Q7TZP1" FT /db_xref="UniProtKB/TrEMBL:Q7TZP1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94464.1" FT /translation="MIATTRDREGATMITFRLRLPCRTILRVFSRNPLVRGTDRLEAVV FT MLLAVTVSLLTIPFAAAAGTAVHDSRSHVYAHQAQTRHPATATVIDHEGVIDSNTTATS FT APPRTKITVPARWVVNGIERSGEVNAKPGTKSGDRVGIWVDSAGQLVDEPAPPARAIAD FT AALAALGLWLSVAAVAGALLALTRAILIRVRNASWQHDIDSLFCTQR" FT CDS complement(32171..32413) FT /transl_table=11 FT /gene="Mb1763c" FT /locus_tag="Mb1763c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1763c, -, len: 80 aa. Equivalent to Rv1734c, len: FT 80 aa, from Mycobacterium tuberculosis strain H37Rv, (98.8% FT identity in 80 aa overlap). Conserved hypothetical protein, FT similar to C-terminal region Q9Z8N2|CP0452|AE001615 FT Dihydrolipoamide Acetyltransferase from Chlamydia FT pneumoniae (429 aa), FASTA scores: opt: 138, E(): 0.0012, FT (26.9% identity in 78 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZP0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94465.1" FT /translation="MTNVGDQGVDAVFGVIYPPQVALVSFGKPAQRVCAVDGAIHVMTT FT VLATLPADHGCSDDHRGALFFLSINELTRCAAVAG" FT CDS complement(32688..33185) FT /transl_table=11 FT /gene="Mb1764c" FT /locus_tag="Mb1764c" FT /product="HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1764c, -, len: 165 aa. Equivalent to Rv1735c, len: FT 165 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 165 aa overlap). Hypothetical membrane protein, FT similar to part of O58614|PH0884|AP000004 Hypothetical FT malic acid transport protein from Pyrococcus horikoshii FT (330 aa), FASTA scores: opt: 167, E(): 0.0003, (29.2% FT identity in 120 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZN9" FT /protein_id="CAD94466.1" FT /translation="MGATAITVLAGAHIVEMADAPMAIVTSGLVAGASVVFWAFGPWLI FT PPLVAASIWKHVVHRVPLRYEATLWSVVFPLGMYGVGAYRLGLAAHLPIVESIGEFEGW FT VALAVWTITFVAMLHHLAATIGRSGRSSHAIGAADDTHAIICRPPRSFDHQVRAFRRNQ FT PM" FT CDS complement(33625..35583) FT /transl_table=11 FT /gene="narX" FT /locus_tag="Mb1765c" FT /product="Probable nitrate reductase NarX" FT /EC_number="1.7.99.4" FT /note="Mb1765c, narX, len: 652 aa. Equivalent to Rv1736c, FT len: 652 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 652 aa overlap). Probable narX, nitrate FT reductase (EC 1.7.99.4). Contains three domains: N-terminus FT (250 aa) is similar to e.g. N-terminus of NARG_ECOLI|P09152 FT respiratory nitrate reductase 1 alpha chain from FT Escherichia coli (1246 aa), FASTA scores: E(): 0, (58.6% FT identity in 251 aa overlap); and Rv1161|MTCI65.28|NARG FT PROBABLE RESPIRATORY NITRATE REDUCTASE (ALPHA CHAIN) from FT Mycobacterium tuberculosis (1232 aa). Central region FT (260-410 aa) is similar to Rv1163|O06561|NARJ PROBABLE FT RESPIRATORY NITRATE REDUCTASE (DELTA CHAIN) from FT Mycobacterium tuberculosis (201 aa), FASTA scores: E(): 0, FT (64.2% identity in 159 aa overlap). C-terminus (420 aa-) is FT similar to Rv1164|O06562|NARI PROBABLE RESPIRATORY NITRATE FT REDUCTASE (GAMMA CHAIN) from M. tuberculosis (246 aa), FT FASTA scores: E(): 0, (68.6% identity in 239 aa overlap). FT Contains PS00551 Prokaryotic molybdopterin oxidoreductases FT signature 1." FT /db_xref="GOA:Q7VEU1" FT /db_xref="HSSP:1Q16" FT /db_xref="InterPro:IPR003816" FT /db_xref="UniProtKB/TrEMBL:Q7VEU1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94467.1" FT /translation="MTVTPRTGSRIEELLARSGRFFIPGEISADLRTVTRRGGRDGDVF FT YRDRWSHHKVVRSTHGVNCTGSCSWKIYVKDGIITWETQETDYPSVGPDRPEYEPRGCP FT RGAAFSWYTYSPTRVRHPYARGVLVEMYREAKARLGDPVAAWADIQADPRRRRRYQRAR FT GKGGLVRVSWAEATEMIAAAHVHTISTYGPDRVAGFSPIPAMSMVSHAAGSRFVELIGG FT VMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDVVWQCASVLLTYPNSRQLGTAEELL FT AHIDGPAADLLGRTVSELRRADPLTAATRYVDTFDLRGRATLYLTYWTAGDTRNRGREM FT LAFAQTYRSTDVAPPRGETPDFLPVVLEFAATVDPEAGRRLLSGYRVPIAALCNALTEA FT ALPYAHTVAAVCRTGDMMGELFWTVVPYVTMTIVAVGSWWRYRYDKFGWTTRSSQLYES FT RLLRIASPMFHFGILVVIVGHGIGLVIPQSWTQAAGLSEGAYHVQAVVLGSIAGITTLA FT GVTLLIYRRRTRGPVFMATTVNDKVMYLVLVAAIVAGLGATALGSGVVGEAYNYRETVS FT VWFRSVWVLQPRGDLMAEAPLYYQIHVLIGLALFALWPFTRLVHAFSAPIGYLFRPYII FT YRSREELVLTRPRRRGW" FT CDS complement(35580..36767) FT /transl_table=11 FT /gene="narK2" FT /locus_tag="Mb1766c" FT /product="POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2" FT /note="Mb1766c, narK2, len: 395 aa. Equivalent to Rv1737c, FT len: 395 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 395 aa overlap). Possible narK2, FT nitrate/nitrite-transport integral membrane protein (see FT first citation below), possibly member of major facilitator FT superfamily (MFS), similar to P46907|NARK_BACSU nitrite FT extrusion protein from Bacillus subtilis (395 aa), FASTA FT scores: opt: 742, E(): 0, (33.6% identity in 375 aa FT overlap); and to AL109989|SCJ12.23 hypothetical FT nitrate/nitrite transporter from Streptomyces coelicolor FT (412 aa), FASTA scores: opt: 1181, E(): 0, (49.4% identity FT in 389 aa overlap)." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q7TZN8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94468.1" FT /translation="MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARDMSLSSAEASL FT LVATPILVGALGRIVTGPLTDRFGGRAMLIAVTLASILPVLAVGVAATMGSYALLVFFG FT LFLGVAGTIFAVGIPFANNWYQPARRGFSTGVFGMGMVGTALSAFFTPRFVRWFGLFTT FT HAIVAAALASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIVFGGF FT VAFSNYLPTYITTIYGFSTVDAGARTAGFALAAVLARPVGGWLSDRIAPRHVVLASLAG FT TALLAFAAALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAASVGSVTGIVAAA FT GGLGGYFPPLVMGATYDPVDNDYTVGLLLLVATALVACTYTALHAREPVSEEASR" FT CDS 37054..37338 FT /transl_table=11 FT /gene="Mb1767" FT /locus_tag="Mb1767" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1767, -, len: 94 aa. Equivalent to Rv1738, len: 94 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 94 aa overlap). Conserved hypothetical protein, FT similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kd FT protein from Mycobacterium tuberculosis (93 aa), FASTA FT scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa FT overlap)." FT /db_xref="InterPro:IPR015057" FT /db_xref="UniProtKB/Swiss-Prot:P64888" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94469.1" FT /translation="MCGDQSDHVLQHWTVDISIDEHEGLTRAKARLRWREKELVGVGLA FT RLNPADRNVPEIGDELSVARALSDLGKRMLKVSTHDIEAVTHQPARLLY" FT CDS complement(37352..39034) FT /transl_table=11 FT /gene="Mb1768c" FT /locus_tag="Mb1768c" FT /product="PROBABLE SULPHATE-TRANSPORT TRANSMEMBRANE PROTEIN FT ABC TRANSPORTER" FT /note="Mb1768c, -, len: 560 aa. Equivalent to Rv1739c, len: FT 560 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 560 aa overlap). Probable FT sulphate-transport transmembrane protein ABC transporter, FT similar to several e.g. P53392|G607186 high affinity FT sulphate transporter from Stylosanthes hamata (662 aa), FT FASTA scores: opt: 382, E(): 1.6e-16, (28.0% identity in FT 564 aa overlap); U59234.1|AAB88215.1 biotin carb. from FT Synechococcus sp. PCC 7942 (574 aa), FASTA scores: opt: FT 1838, E(): 0, (50.0% identity in 550 aa overlap); etc. FT Contains PS00211 ABC transporters family signature. BELONGS FT TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS), AND SEEMS TO BELONG TO THE SULP FAMILY." FT /db_xref="GOA:Q7TZN7" FT /db_xref="InterPro:IPR001902" FT /db_xref="UniProtKB/TrEMBL:Q7TZN7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94470.1" FT /translation="MIPTMTSAGWAPGVVQFREYQRRWLRGDVLAGLTVAAYLIPQAMA FT YATVAGLPPAAGLWASIAPLAIYALLGSSRQLSIGPESATALMTAAVLAPMAAGDLRRY FT AVLAATLGLLVGLICLLAGTARLGFLASLLSRPVLVGYMAGIALVMISSQLGTITGTSV FT EGNEFFSEVHSFATSVTRVHWPTFVLAMSVLALLTMLTRWAPRAPGPIIAVLAATMLVA FT VMSLDAKGIAIVGRIPSGLPTPGVPPVSVEDLRALIIPAAGIAIVTFTDGVLTARAFAA FT RRGQEVNANAELRAVGACNIAAGLTHGFPVSSSSSRTALADVVGGRTQLYSLIALGLVV FT IVMVFASGLLAMFPIAALGALVVYAALRLIDLSEFRRLARFRRSELMLALATTAAVLGL FT GVFYGVLAAVALSILELLRRVAHPHDSVLGFVPGIAGMHDIDDYPQAKRVPGLVVYRYD FT APLCFANAEDFRRRALTVVDQDPGQVEWFVLNAESNVEVDLTALDALDQLRTELLRRGI FT VFAMARVKQDLRESLRAASLLDKIGEDHIFMTLPTAVQAFRRR" FT CDS 39102..39314 FT /transl_table=11 FT /gene="Mb1769" FT /locus_tag="Mb1769" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1769, -, len: 70 aa. Equivalent to Rv1740, len: 70 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 70 aa overlap). Conserved hypothetical protein, FT highly similar to other Mycobacterium tuberculosis FT hypothetical proteins e.g. P96913|Rv0623|MTCY20H10.04 (84 FT aa), (73.5% identity in 68 aa overlap); P71998|Rv1740 (70 FT aa), and O07770|Rv0608 (81 aa)." FT /db_xref="InterPro:IPR011660" FT /db_xref="UniProtKB/TrEMBL:Q7TZN6" FT /protein_id="CAD94471.1" FT /translation="MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRR FT CAALPVLDTRAADTILGYDERGLPA" FT CDS 39314..39562 FT /transl_table=11 FT /gene="Mb1770" FT /locus_tag="Mb1770" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1770, -, len: 82 aa. Equivalent to Rv1741, len: 82 FT aa, from Mycobacterium tuberculosis strain H37Rv, (98.8% FT identity in 82 aa overlap). Conserved hypothetical protein, FT very similar in N-terminus to other M. tuberculosis FT hypothetical proteins e.g. P96914|Rv0624|MTCY20H10.05 (131 FT aa), (80.4% identity in 56 aa overlap); P71999|Rv1741 (82 FT aa) and O07769|Rv0609 (133 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7TZN5" FT /protein_id="CAD94472.1" FT /translation="MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVI FT ETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVLAG" FT CDS 39643..40308 FT /transl_table=11 FT /gene="Mb1771" FT /locus_tag="Mb1771" FT /product="HYPOTHETICAL PROTEIN [SECOND PART]" FT /note="Mb1771, -, len: 221 aa. Equivalent to the 3' end of FT Rv1742, len: 245 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100% identity in 220 aa overlap). Hypothetical FT unknown protein. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a single base insertion (*-c) leads to FT shorter product with a different NH2 part compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv." FT /db_xref="UniProtKB/TrEMBL:Q7TZN4" FT /protein_id="CAD94473.1" FT /translation="MGRVRTGGLLLRTRVPGNRFADYRITVHVQQARTVLDPFPRDGYR FT GVFESGQVRIESHDGAVISSRAHPRAAFFGRSGLRRNIRWDPLDSVYFAGYAMWNYLTT FT PYLLTREGVAVEEGAPWQQEGETWRRLIVSFPPDIDTHSPRQTFYVDASGLLRRHDYVP FT EVVGHWARAAHYCADPVDVDGFVFPTCRWVHPIGPGNRSLPFPTLVSILLTDIRVETD" FT CDS 40402..42102 FT /transl_table=11 FT /gene="pknE" FT /locus_tag="Mb1772" FT /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN FT KINASE E PKNE (PROTEIN KINASE E) (STPK E)" FT /EC_number="2.7.1.-" FT /note="Mb1772, pknE, len: 566 aa. Equivalent to Rv1743, FT len: 566 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 566 aa overlap). Probable pknE, FT transmembrane serine/threonine protein kinase (EC 2.7.1.-) FT (see citation below), similar to PKN1_MYXXA|P33973 FT serine/threonine-protein kinase pkn1 (693 aa), fasta FT scores: opt: 542, E(): 1.1e-19, (35.8% identity in 302 aa FT overlap). Also highly similar to K08G_MYCTU|Q11053 probable FT serine/threonine-protein kinase (626 aa) (59.8% identity in FT 381 aa overlap). Contains PS00107 Protein kinases FT ATP-binding region signature. Contains Hank's kinase FT subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN FT KINASES." FT /db_xref="GOA:Q7TZN3" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:Q7TZN3" FT /protein_id="CAD94474.1" FT /translation="MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALK FT LMSETLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAM FT LRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASA FT TTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSV FT MGAHINQAIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQD FT RATDILRRSQVAKLPVPSTHPVSPGTRWPQPTPWAGGAPPWGPPSSPLPRSARQPWLWV FT GVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGVFVGSSVAPT FT TIDIFNEPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAA FT SYCVAGQNDPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQTVGAEPTAISCIKS FT GADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG" FT CDS complement(42387..42788) FT /transl_table=11 FT /gene="Mb1773c" FT /locus_tag="Mb1773c" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb1773c, -, len: 133 aa. Equivalent to Rv1744c, len: FT 133 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 133 aa overlap). Probable membrane FT protein, contains four imperfect 10 aa repeats, some FT similarity to Q25946 (MSA-2) (FRAGMENT) from Plasmodium FT falciparum (205 aa), FASTA scores: opt: 145, E( ): 0.048, FT (52.4% identity in 63 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZN2" FT /protein_id="CAD94475.1" FT /translation="MVINRSIASIDSIAVAGSAATTGAVAVAGSVATAGSVAVAGSVAT FT AGSVAIAGAAATAGSVGIIGSLLTVLCVAVRQCVACLACITCTRCVACIGCVRCTDCVG FT CLWCVNCSGLRNVVGAQNLRVGNLGRVSN" FT CDS complement(42859..43389) FT /transl_table=11 FT /gene="idi" FT /locus_tag="Mb1774c" FT /product="Probable isopentenyl-diphosphate delta-isomerase FT IDI (IPP isomerase) (Isopentenyl pyrophosphate isomerase)" FT /EC_number="5.3.3.2" FT /note="Mb1774c, idi, len: 176 aa. Equivalent to Rv1745c, FT len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 176 aa overlap). Probable idi, FT isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2), FT similar to Q46822|ORF_O182 from Escherichia coli (182 aa), FT FASTA scores: opt: 465, E(): 4.7e-25, (46.9% identity in FT 162 aa overlap), and to IPPI_SCHPO|Q10132 FT isopentenyl-diphosphate delta-isomerase from FT Schizosaccharomyces pombe (227 aa), FASTA scores: opt: 185, FT E(): 5.4e-06, (30.3% identity in 152 aa overlap). BELONGS FT TO THE IPP ISOMERASE TYPE 1 FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT truncation at the 3' end due to a single base tranversion FT (g-t), leads to a shorter product compared to its homolog FT in Mycobacterium tuberculosis strain H37Rv (176 aa versus FT 203 aa)." FT /db_xref="GOA:Q7VEU0" FT /db_xref="InterPro:IPR000086" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEU0" FT /protein_id="CAD94476.1" FT /translation="MTRSYRPAPPIERVVLLNDRGDATGVADKATVHTGDTPLHLAFSS FT YVSDLHDQLLITRRAATKRTWPAVWTNSCCGHPLPGESLPGAIRRRLAAELGLTPDRVD FT LILPGFRYRAAMADGTVENEICPVYRVQVDQQPRPNSDEVDAIRWLSWEQFVRDVTAGV FT IAPVSPWCRSQLG" FT CDS 43536..44966 FT /transl_table=11 FT /gene="pknF" FT /locus_tag="Mb1775" FT /product="ANCHORED-MEMBRANE SERINE/THREONINE-PROTEIN KINASE FT PKNF (PROTEIN KINASE F) (STPK F)" FT /EC_number="2.7.1.-" FT /note="Mb1775, pknF, len: 476 aa. Equivalent to Rv1746, FT len: 476 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 476 aa overlap). pknF, transmembrane FT serine/threonine-protein kinase (EC 2.7.1.-) (see citations FT below), highly similar to KY28_MYCTU|Q10697 probable FT serine/threonine-protein kinase from Mycobacterium FT tuberculosis (589 aa), FASTA scores: opt: 870, E(): 0, FT (41.6% identity in 406 aa overlap). Contains PS00108 FT Serine/Threonine protein kinases active-site signature. FT Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FT FAMILY OF PROTEIN KINASES. Experimental studies show FT evidence of auto-phosphorylation. Start site chosen by FT homology, may extend further upstream." FT /db_xref="GOA:Q7TZN1" FT /db_xref="HSSP:1Q99" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:Q7TZN1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94477.1" FT /translation="MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRA FT DVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDR FT YPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADFGIA FT GWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPFQHAN FT PAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGHRLGGA FT GDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVTVREFQRADDERAAQP FT ARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALCFPLGSTG FT TTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESPIRVCMQQT FT GQTRRECREEIRRSNGWP" FT CDS 45028..47625 FT /transl_table=11 FT /gene="Mb1776" FT /locus_tag="Mb1776" FT /product="PROBABLE CONSERVED TRANSMEMBRANE ATP-BINDING FT PROTEIN ABC TRANSPORTER" FT /note="Mb1776, -, len: 865 aa. Equivalent to Rv1747, len: FT 865 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 865 aa overlap). Probable conserved FT transmembrane ATP-binding protein ABC transporter (see FT citation below), similar to others e.g Q55956 ABC FT transporter from Synechocystis sp. (790 aa), FASTA scores: FT opt: 738, E(): 6.3e-26, (31.6% identity in 632 aa overlap); FT etc. Also similar to other Mycobacterium tuberculosis FT ABC-type transporters e.g. Rv2397c|MTCY253.24, FASTA score: FT (35.2% identity in 213 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), and PS00211 ABC FT transporters family signature. BELONGS TO THE ATP-BINDING FT TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7TZN0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TZN0" FT /protein_id="CAD94478.1" FT /translation="MPMSQPAAPPVLTVRYEGSERTFAAGHDVVVGRDLRADVRVAHPL FT ISRAHLLLRFDQGRWVAIDNGSLNGLYLNNRRVPVVDIYDAQRVHIGNPDGPALDFEVG FT RHRGSAGRPPQTTSIRLPNLSAGAWPTDGPPQTGTLGSGQLQQLPPATTRIPAAPPSGP FT QPRYPTGGQQLWPPSGPQRAPQIYRPPTAAPPPAGARGGTEAGNLATSMMKILRPGRLT FT GELPPGAVRIGRANDNDIVIPEVLASRHHATLVPTPGGTEIRDNRSINGTFVNGARVDA FT ALLHDGDVVTIGNIDLVFADGTLARREENLLETRVGGLDVRGVTWTIDGDKTLLDGISL FT TARPGMLTAVIGPSGAGKSTLARLVAGYTHPTDGTVTFEGHNVHAEYASLRSRIGMVPQ FT DDVVHGQLTVKHALMYAAELRLPPDTTKDDRTQVVARVLEELEMSKHIDTRVDKLSGGQ FT RKRASVALELLTGPSLLILDEPTSGLDPALDRQVMTMLRQLADAGRVVLVVTHSLTYLD FT VCDQVLLLAPGGKTAFCGPPTQIGPVMGTTNWADIFSTVADDPDAAKARYLARTGPTPP FT PPPVEQPAELGDPAHTSLFRQFSTIARRQLRLIVSDRGYFVFLALLPFIMGALSMSVPG FT DVGFGFPNPMGDAPNEPGQILVLLNVGAVFMGTALTIRDLIGERAIFRREQAVGLSTTA FT YLIAKVCVYTVLAVVQSAIVTVIVLVGKGGPTQGAVALSKPDLELFVDVAVTCVASAML FT GLALSAIAKSNEQIMPLLVVAVMSQLVFSGGMIPVTGRVPLDQMSWVTPARWGFAASAA FT TVDLIKLVPGPLTPKDSHWHHTASAWWFDMAMLVALSVIYVGFVRWKIRLKAC" FT CDS 47998..48729 FT /transl_table=11 FT /gene="Mb1777" FT /locus_tag="Mb1777" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1777, -, len: 243 aa. Equivalent to Rv1748, len: FT 243 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 243 aa overlap). Hypothetical unknown protein. FT Possibly exported protein, hydrophobic domain, TM helix aa FT 23-45." FT /db_xref="UniProtKB/TrEMBL:Q7TZM9" FT /protein_id="CAD94479.1" FT /translation="MPGGVCSGRPWGRPWWHPGLVGLLIRLAELLVVMLPLIGVLYVGI FT KALSSFTRRLGEASGDLASDSPAMPRPTTVENDAARWRAITRAVEAHERTDARWLEYEL FT DAAKLLDFPVMTDMRDPLTTAFHKAKLQADFHKPLRAEDLLDDPDAAGHYLDAVRDYVT FT AFDTAEAEAMRRRRTGFSREEQQRLARAQSLLRVASDAGATAQERERAYRLARTELDGL FT IVLPDRTRAGIERGIAGELDD" FT CDS complement(48726..49283) FT /transl_table=11 FT /gene="Mb1778c" FT /locus_tag="Mb1778c" FT /product="POSSIBLE INTEGRAL MEMBRANE PROTEIN" FT /note="Mb1778c, -, len: 185 aa. Equivalent to Rv1749c, len: FT 185 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 185 aa overlap). Possible integral membrane FT protein, similar to O27914|AE000940 hypothetical protein FT MTH1892 from Methanobacterium thermoautotrophicum (168 aa), FT fasta scores: E(): 9.3e-16, (37.4% identity in 123 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZM8" FT /protein_id="CAD94480.1" FT /translation="MLRAVNEIRQHDGTLKLGKGVGMFTIVGVIVALIGAFVQSRRHRH FT RPAADIHMLWWMVLIVGVVSIIGAGYHVFDGERTAELIGYTRGDGGFQWENAMGDLAIG FT VVGLMAYRFRGHFWLATIVVLTIQYVGDAAGHIYYWVVENNTNPYNIGVPLWTDILLPI FT VMWALYAWSWHSNGDAVPKGQP" FT CDS complement(49367..50965) FT /transl_table=11 FT /gene="fadD1" FT /locus_tag="Mb1779c" FT /product="POSSIBLE FATTY-ACID-COA LIGASE FADD1 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1779c, fadD1, len: 532 aa. Equivalent to Rv1750c, FT len: 532 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 532 aa overlap). Possible fadD1, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to FT others e.g. O35488|VLCS_MOUSE VERY-LONG-CHAIN ACYL-COA FT SYNTHETASE from Mus musculus (620 aa); FT NP_113924.1|NM_031736 solute carrier family 27 (fatty acid FT transporter) member 2 from Rattus norvegicus (620 aa); FT NP_459076.1|NC_003197 crotonobetaine/carnitine-CoA ligase FT from Salmonella typhimurium (517 aa); CAIC_ECOLI|P31552 FT probable crotonobetaine/carnitine-coa ligase from FT Escherichia coli (522 aa), FASTA scores: opt: 448, E(): FT 1.9e-21, (25.1% identity in 502 aa overlap); etc. Also FT highly similar to fadD17|Rv3506|MTV023.13 PROBABLE FT FATTY-ACID-COA LIGASE from Mycobacterium tuberculosis (502 FT aa); and similar to others from Mycobacterium tuberculosis FT e.g. fadD6|MTCI364.18|Rv1206|O05307 PROBABLE FATTY-ACID-COA FT LIGASE (597 aa), FASTA score: (28.3% identity in 519 aa FT overlap); etc. Contains PS00455 Putative AMP-binding domain FT signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FT FAMILY." FT /db_xref="GOA:Q7TZM7" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TZM7" FT /protein_id="CAD94481.1" FT /translation="MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALIT FT IADPQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRADCQIVV FT TDADHRALLDGLDLAGARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSGTSG FT NPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGAAIAP FT ATFSATGFLDDVRRYHATYMNYVGKPLAYILATPERDDDADNPLRVAFGNEANDKDIEE FT FSRRFGVQVEDGFGSTENAVIVIREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAH FT GALTNADEAIGELVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAG FT RTADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRAGDTFDP FT DAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDEGTAVGKADTLWVREP FT RGSAYHHASGPAKAI" FT CDS 51019..52401 FT /transl_table=11 FT /gene="Mb1780" FT /locus_tag="Mb1780" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1780, -, len: 460 aa. Equivalent to Rv1751, len: FT 460 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 460 aa overlap). Probable oxidoreductase FT (EC 1.-.-.-), possibly a monooxygenase or hydroxylase, FT similar to MHPA_ECOLI|P77397 3-(3-hydroxy-phenyl) FT propionate hydroxylase (554 aa), FASTA scores: opt: 239, FT E(): 2e-08, (24.6% identity in 435 aa overlap); and FT AJ007932|SAR7932.13 oxygenase from Streptomyces argillaceus FT (436 aa), FASTA scores: opt: 587, E(): 8.6e-30, (32.3% FT identity in 359 aa overlap). Contains PS00075 Dihydrofolate FT reductase signature. Also similar to Mycobacterium FT tuberculosis hypothetical oxidoreductases Rv1260 and FT Rv0575c." FT /db_xref="GOA:Q7TZM6" FT /db_xref="InterPro:IPR003042" FT /db_xref="UniProtKB/TrEMBL:Q7TZM6" FT /protein_id="CAD94482.1" FT /translation="MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYA FT RALMGETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTTMRLL FT DELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVAMVPQWDLLNLLAEA FT AQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEGPGELRAELTVACDGRWSIARHEAG FT LKAREFPVNFDVWWFKLPREGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQ FT LRERGIEEFRRDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAH FT AMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAVTQAVQRVL FT HRRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGVRPEHAPAFARRGPGNRK FT GP" FT CDS 52528..52977 FT /transl_table=11 FT /gene="Mb1781" FT /locus_tag="Mb1781" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1781, -, len: 149 aa. Equivalent to Rv1752, len: FT 149 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 149 aa overlap). Conserved hypothetical FT protein, similar to C-terminal half of FT Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase (EC FT 1.3.1.20) from Canis familiaris (335 aa), FASTA score, opt: FT 168, E(): 0.00015, (31.3% identity in 112 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZM5" FT /protein_id="CAD94483.1" FT /translation="MDAGCYAVHMAHTFGGATPEVVSAQAKLRDPAVDRAMTAELKFPG FT GHTGGIRCSMRSSDLLNVSARVVGDRGELRVLNPVVPQLFHRLPPLACVSARRFRCRSA FT ARASGQDDAQGRGREHERDPRDLSGRRAPIAQPELNMVAASGSAA" FT CDS complement(53012..56167) FT /transl_table=11 FT /gene="PPE24" FT /locus_tag="Mb1782c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1782c, PPE24, len: 1051 aa. Similar to Rv1753c, FT len: 1053 aa, from Mycobacterium tuberculosis strain H37Rv, FT (90.7% identity in 1103 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of Gly-, Asn-rich FT proteins, similar to many e.g. YF48_MYCTU|Q10778 FT hypothetical protein cy48.17 (678 aa), FASTA scores: opt: FT 1360, E(): 0, (48.9% identity in 550 aa overlap). Note that FT the Gly-, Asn-rich sequence is interrupted by six FT near-perfect 26 aa repeats, a unique region, and another, FT more degenerate region of five 25 aa repeats before FT resuming at the C-terminus. The end of the first Gly-, Asn- FT rich region and the start of the first set of repeats shows FT some similarity to Q50577|AT10S from Mycobacterium FT tuberculosis (170 aa) (40.2% identity in 189 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT 150 bp insertion and a 156 bp deletion, leads to a shorter FT product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (1051 aa versus 1053 aa)." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7TZM4" FT /protein_id="CAD94484.1" FT /translation="MNFSVLPPEINSALIFAGAGPEPMAAAATAWDGLAMELASAAASF FT GSVTSGLVGGAWQGASSSAMAAAAAPYAAWLAAAAVQAEQTAAQAAAMIAEFEAVKTAV FT VQPMLVAANRADLVSLVMSNLFGQNAPAIAAIEATYEQMWAADVSAMSAYHAGASAIAS FT ALSPFSKPLQNLAGLPAWLASGAPAAAMTAAAGIPALAGGPTAINLGIANVGGGNVGNA FT NNGLANIGNANLGNYNFGSGNFGNSNIGSASLGNNNIGFGNLGSNNVGVGNLGNLNTGF FT ANTGLGNFGFGNTGNNNIGIGLTGNNQIGIGGLNSGTGNFGLFNSGSGNVGFFNSGNGN FT FGIGNSGNFNTGGWNSGHGNTGFFNAGSFNTGMLDVGNANTGSLNTGSYNMGDFNPGSS FT NTGTFNTGNANTGFLNAGNINTGVFNIGHMNNGLFNTGDMNNGVFYRGVGQGSLQFSIT FT TPDLTLPPLQIPGISVPAFSLPAITLPSLTIPAATTPANITVGAFSLPGLTLPSLNIPA FT ATTPANITVGAFSLPGLTLPSLNIPAATTPANITVGAFSLPGLTLPSLNIPAATTPANI FT TVSGFQLPPLSIPSVAIPPVTVPPITVGAFNLPPLQIPEVTIPQLTIPAGITIGGFSLP FT AIHTQPITVGQIGVGQFGLPSIGWDVFLSTPRITVPAFGIPFTLQFQTNVPALQPPGGG FT LSTFTNGALIFGEFDLPQLVVHPYTLTGPIVIGSFFLPAFNIPGIDVPAINVDGFTLPQ FT ITTPAITTPEFAIPPIGVGGFTLPQITTQEIITPELTINSIGVGGFTLPQITTPPITTP FT PLTIDPINLTGFTLPQITTPPITTPPLTIDPINLTGFTLPQITTPPITTPPLTIDPINL FT TGFTLPQITTPPITTPPLTIDPINLTGFTLPQITTPPITTPPLTIEPIGVGGFTTPPLT FT VPGIHLPSTTIGAFAIPGGPGYFNSSTAPSSGFFNSGAGGNSGFGNNGSGLSGWFNTNP FT AGLLGGSGYQNFGGLSSGFSNLGSGVSGFANRGILPFSVASVVSGFANIGTNLAGFFQG FT TTS" FT CDS complement(56371..58062) FT /transl_table=11 FT /gene="Mb1783c" FT /locus_tag="Mb1783c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1783c, -, len: 563 aa. Equivalent to Rv1754c, len: FT 563 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 563 aa overlap). Conserved hypothetical FT protein, has proline-rich central region. Some similarity FT in central region to other Mycobacterium tuberculosis FT proline-rich proteins e.g. O06555|Rv1157c|MTCI65.24c (371 FT aa), (32.5% identity in 191 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="UniProtKB/TrEMBL:Q7TZM3" FT /protein_id="CAD94485.1" FT /translation="MYRYQVRVQQRRSEMNRWVATRSRRHTYQWITDHKSPRDHYRHIS FT ELRTSIATSSPGRCDMSPIPRIVSVSLAWAAAIGLMVPIGLAPPAMAAPCSGDAANAPP FT PPSAIVTDPGATALGPVRPGHGPIPTGRKPRGANDRAPLPKLGPLISALLNPGARNAAP FT LQQQALVPRANPGPNPAPNPPATGPQPPNATQLTPNPAPAPDPAPAAAPDPGATLAGAT FT TSLAEWVTGPDSPNKTLERFGISGTDLGIPWDNGDPANRQVLMIFGDTFGYCAVDGHQW FT RYNTLFRSQDRDLGNGVHVTSGDASNRYSGSPVRQPGFSKQLINSIKWARDETGIIPTA FT GIAVGKTQYVNFMSIRNWGRDGEWTTNYSGIAVSKDNGQTWGVFPGTIRASGPDSGGKA FT RFVPGNENFQMGAYLKSNDGYLYSFGTPPGRGGSAYLARVPQRFVPDLTKYQYWNGDSN FT SWVPNKPDAATPVIPGPVGEMSVQYNTYLKQYLALYTNGMNDVVARTAPAPQGPWSAEQ FT MLVSSWQMPGGIYAPMMHPWSTGKDVYFNLSLWSAYNVMLMHTVLP" FT CDS complement(58246..59790) FT /transl_table=11 FT /gene="plcD" FT /locus_tag="Mb1784c" FT /product="PROBABLE PHOSPHOLIPASE C 4 PLCD" FT /EC_number="3.1.4.3" FT /note="Mb1784c, plcD, len: 514 aa. Equivalent to MT1799, FT len: 514 aa, from Mycobacterium tuberculosis strain FT CDC1551, (100% identity in 514 aa overlap). Probable plcD, FT phospholipase C 4 (EC 3.1.4.3) (see citation below), highly FT similar to other phospholipases e.g. FT Q04001|PHLA_MYCTU|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c FT PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA from FT Mycobacterium tuberculosis (512 aa), FASTA score: opt: FT 2657, E(): 4.9e-156, (71.1% identity in 512 aa overlap); FT P95246|PHLB_MYCTU|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c FT PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB from FT Mycobacterium tuberculosis (512 aa), FASTA score: opt: FT 2638, E(): 7.3e-155, (70.9% identity in 512 aa overlap); FT etc. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY. FT REMARK-M.bovis-M.tuberculosis: No equivalent in FT Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 FT region." FT /db_xref="GOA:P0A5R9" FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/Swiss-Prot:P0A5R9" FT /protein_id="CAD94486.1" FT /translation="MSQSHIGGVSRREFLAKVAAGGAGALMSFAGPVIEKAYGAGPCSG FT HLTDIEHFVFFMQENRSFDHYFGTLSGTDGFNTVSPLFQQKGWNPMTQALDATGVTMPY FT RFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQAKTRSAAHTPTVMGYYTR FT QDIPIHYLLADAFTVCDRYFCSVLGPTLPNRLYWLSATIDPDGQNGGPELQSPTFQPVR FT RFGWRIMPQNLSDAGVSWKVYRNKTLGPISSVLTYGSLVTSFKQSADPRSDLVRFGVAP FT SYPASFAADVLANRLPRVSWVIPNVLESEHPAVPAAAGAFAIVNILRILLANPAVWEKT FT ALIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLGFRVPCFVI FT SPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVTGDMTSTFNFAVPPNSSW FT PNLDYPGLHALSTVPQCVPNAALGTINRGIPYRVPDPQIMPTQETTPTRGIPSGPC" FT CDS complement(59919..61103) FT /transl_table=11 FT /gene="Mb1785c" FT /locus_tag="Mb1785c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1785c, -, len: 394 aa. Similar to MT1800 (also FT known as RVD2-ORF1), len: 381 aa, from Mycobacterium FT tuberculosis strain CDC1551, (99.71% identity in 345 aa FT overlap). Conserved hypothetical protein (see citation FT below), showing similarity with glycosyl transferases, FT sulfolipid sulfoquinovosyldiacylglycerol synthases, and FT hypothetical proteins, e.g. Q9R6U1|SQDX SQDX PROTEIN FT (required for biosynthesis of the sulfolipid FT sulfoquinovosyldiacylglycerol) from Synechococcus sp. FT strain PCC 7942 (Anacystis nidulans R2) (377 aa), FASTA FT scores: opt: 348, E(): 6.7e-15, (30.40% identity in 296 aa FT overlap); Q8YUR9|SQDX|ALR2265 SULFOLIPID FT SULFOQUINOVOSYLDIACYLGLYCEROL BIOSYNTHESIS PROTEIN from FT Anabaena sp. strain PCC 7120 (378 aa), FASTA scores: opt: FT 336, E(): 4e-14, (27.832% identity in 309 aa overlap); FT Q9AA50|CC0756 GLYCOSYL TRANSFERASE (GROUP 1 FAMILY PROTEIN) FT from Caulobacter crescentus (455 aa), FASTA scores: opt: FT 333, E(): 7.1e-14, (29.5% identity in 315 aa overlap); etc. FT REMARK-M.bovis-M.tuberculosis: No equivalent in FT Mycobacterium tuberculosis strain H37Rv. Belongs to the FT RvD2 region." FT /db_xref="GOA:Q7TZM2" FT /db_xref="InterPro:IPR001296" FT /db_xref="UniProtKB/TrEMBL:Q7TZM2" FT /protein_id="CAD94487.1" FT /translation="MSLTAHDGRFCSRYACCSGRQLLWTSLGRTPHRGGPAGRGILRQR FT TRGVLIVPGARTERHLLRTGVVRITLPAKHIPYTGGYRAVMPGAVRTVLETLRPDTLEV FT SDRLTLRSLGRWGREHGVTTVMISHERLDRFAGQLLPRRAAQKFADFANARTAANYDTV FT VCTTGFAREEFDRIGATNTVTVPLGVDLKTFHPRRRCARVRQHWATPTQILLVHCGRLS FT VEKHADRSIDALAALCDAGVDARLVIAGEGPLRARLERKATGLPIDFTGFISDRHAVAG FT LLASADVALAPGPHETFGLAALESLACGTPAVVSRTSALTEIITADSGACADNRPEAIA FT HAVRTIVSRPERHRRRCARRRAEIFTWQRAAASMLATLGAMAVSTRCGDTQDTA" FT CDS 61253..62392 FT /transl_table=11 FT /gene="Mb1786" FT /locus_tag="Mb1786" FT /product="POSSIBLE SULFITE OXIDASE" FT /EC_number="1.8.3.1" FT /note="Mb1786, -, len: 379 aa. Equivalent to MT1801, len: FT 379 aa, from Mycobacterium tuberculosis strain CDC1551, FT (99.75% identity in 379 aa overlap). See citations below. FT Possible sulfite oxidase (EC 1.8.3.1), showing similarity FT with others e.g. P51687|SUOX_HUMAN Sulfite oxidase, FT mitochondrial precursor from Homo sapiens (488 aa), FASTA FT scores: opt: 952, E(): 6.1e-52, (43.7% identity in 357 aa FT overlap); Q07116|SUOX_RAT Sulfite oxidase, mitochondrial FT precursor from Rattus norvegicus (488 aa), FASTA scores: FT opt: 952, E(): 6.1e-52, (43.8% identity in 356 aa overlap); FT Q9VWP4|CG7280 PROBABLE SULFITE OXIDASE PRECURSOR from FT Drosophila melanogaster (Fruit fly) (573 aa), FASTA scores: FT opt: 764, E(): 4e-40, (38.4% identity in 362 aa overlap); FT etc. REMARK-M.bovis-M.tuberculosis: No equivalent in FT Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 FT region." FT /db_xref="GOA:Q7TZM1" FT /db_xref="InterPro:IPR008335" FT /db_xref="UniProtKB/TrEMBL:Q7TZM1" FT /protein_id="CAD94488.1" FT /translation="MTDRGENRTTIAMLETAGLWGKRADMIVRGCLPYNAEPPPAVLAG FT SDITPINAFYVRNHGPVPDIAPQHWRLTVGGLVDNPLTVTYERLTTEFDQHCVVATLAC FT AGNRRAELLRVRQIPGKEPWAHGAISTAQWCGVRLADILQAADVHIDEGLHVAFDAPDV FT AEEARPIQPYGSSIPLSKALSPEVLLAWQMNSEPLPRAHGGPVRVVVPGFIGARSVKWV FT TAITVQPGASQNYFQALDYRILPADADADIVGPGEGISLSSLALNCDILDPTDGDDVPA FT GALTIRGYGMAGDGRSVERVDVSVDDGLTWQQADLHAAPSQWSWRPWSLTVDVEPGPLG FT ITARAWDDTGALQPESAVSLWNPRGYGNNAWARVALRVS" FT CDS 62593..65430 FT /transl_table=11 FT /gene="mmpL14" FT /locus_tag="Mb1787" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL14" FT /note="Mb1787, mmpL14, len: 945 aa. Equivalent to MT1802 FT (also known as RVD2-ORF3), len: 945 aa, from Mycobacterium FT tuberculosis strain CDC1551, (99.7% identity in 945 aa FT overlap). Probable mmpL14, conserved transmembrane FT transport protein (see citation below). Member of RND FT superfamily, similar to several putative transport proteins FT e.g. O53784|MML5_MYCTU|MMPL5|Rv0676c|MT0705|MTV040.04c FT PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from FT Mycobacterium tuberculosis strain H37Rv (964 aa), FASTA FT scores: opt: 1171, E(): 2.5e-61, (32.10% identity in 947 aa FT overlap); FT P95211|MML1_MYCTU|MMPL1|Rv0402c|MT0412|MTCY04D9.15c FT PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from FT Mycobacterium tuberculosis strain H37Rv (958 aa), FASTA FT scores: opt: 1170, E(): 2.8e-61, (33.1% identity in 940 aa FT overlap); etc. BELONGS TO THE MMPL FAMILY. FT REMARK-M.bovis-M.tuberculosis: No equivalent in FT Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 FT region." FT /db_xref="GOA:Q7TZM0" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/TrEMBL:Q7TZM0" FT /protein_id="CAD94489.1" FT /translation="MTAIGRLIHRYAIWIVGVWALAAIIGNNFAPPLEQVITAEDQPFS FT PAGTATSRAVERSAAAFSQAPGDNIGYLVLERNGVLNDQDRAYYDALVVALRRDSRHVI FT EVVDWWGTPAIAEVARSDDHHAVTAALRFGGMVGTSQAGESITAARSIVTQLHPPDGLH FT VFVTGPGATIVDEFAAIDRQTQLITATTIVVLLILLLIVYRSAITATVPLLSVVVSLAV FT AKPIVSVLVDRDFIGISLFSLGLSVAVVVGAGTGFAMFLIGRYHERRRQHIAPAAALAD FT AYRGVAPAIAGATFIVVTSLGAVGWLSLARIGMFATTGILCSIGVLAVGLAALTLTPAL FT VALASRANLLKPPQHKRIQRQFRRLGTHVARWPAPILVASGVFVLIMMIALPRVPIGWD FT EAAATPSAAESNRGYRAADRHFAPNQLLPTQVMIETDHDIRNPAGLTAIERITAAIMAI FT GGVRMVQSASHPNGMVSKQAALTASAGNLGDQLDEFSDQLTSRQATFTNLEAAVRDVVS FT ALDLVQAGIRQDGYGLGQVSLAVRLMQQAITKLQGSAGDVFDIFDPLRRFVAAIPECRA FT NPVCSVAQEVVQWANTVTESCAKLADAAGQLARGIADVASATSGVSGLPNALDGIGGQL FT AQVRESAAGVQELLNNVGAAPLRELPDYLRELAAVSQSAPGVDLYAARRILTDPNMRAV FT LDYFVSPNGHATRLLVYGDGSEWGDDGAQRARAIVTAVAEETDEGTLRPTAVELTGVGP FT ATRDLQDLVGSDLTLLAVITLAVIFAIAALLLRSPLAGLVVVGTIATSYICALGASVVI FT WKHILGDNLHWSVLPIAFVLLISVGSAYNLLFALRIREESPAGPRTSVIRAFAATGMVV FT TAAGIVFGTTMFALAASTSLSVAQIGVTVGMGLLLDALVIRGFVLPALMVLLGRWLWWP FT RRSVSNRQVPEPSPA" FT CDS 65751..66407 FT /transl_table=11 FT /gene="cut1" FT /locus_tag="Mb1788" FT /product="PROBABLE CUTINASE CUT1" FT /EC_number="3.1.1.-" FT /note="Mb1788, -, len: 218 aa. Similar to Rv1758, len: 174 FT aa, from Mycobacterium tuberculosis strain H37Rv, (98.25% FT identity in 172 aa overlap). Probable cut1, serine FT esterase, cutinase family (EC 3.1.1.-), similar to FT Rv2301|CUT2_MYCTU|Q50664 probable cutinase cy339.08c FT precursor from Mycobacterium tuberculosis (219 aa), FASTA FT scores: opt: 369, E(): 1. 1e-16, (39.1% identity in 179 aa FT overlap). Also similar to Mycobacterium tuberculosis FT hypothetical cutinases Rv3452, Rv1984c, Rv3451 and Rv3724. FT CDS has been interrupted by IS6110 insertion element and FT 5'-end deleted. BELONGS TO THE CUTINASE FAMILY. FT REMARK-M.bovis-M.tuberculosis: Belongs to the RvD2 region. FT In Mycobacterium tuberculosis strain H37Rv, Rv1758 is FT interrupted by IS6110 insertion element and the 5'-end is FT deleted." FT /db_xref="GOA:Q7TZL9" FT /db_xref="HSSP:1CUU" FT /db_xref="InterPro:IPR000675" FT /db_xref="UniProtKB/TrEMBL:Q7TZL9" FT /protein_id="CAD94490.1" FT /translation="MVTTWALLFAPVPAASADPPDPTVSDGACPDVEVVFARGTGEPPG FT VGGIGEDFIDALRSKIGEKSMGVYGVDYPATTDFPTAMAGIYDAGTHVEQTAANCPQSK FT LVLGGFSQGAAVMGFVTAAAIPDGAPLDAPRPMPPEVADHVAAVTLFGMPSVAFMHSIG FT APPIVIGPLYAEKTIQLCAPGDPVCSSGGNWAAHNGYADDGMVEQAAVFAAGRLG" FT CDS complement(66674..69136) FT /transl_table=11 FT /gene="wag22b" FT /locus_tag="Mb1789c" FT /product="PE-PGRS FAMILY PROTEIN WAG22B [SECOND PART]" FT /note="Mb1789c, wag22b, len: 820 aa. Equivalent to 3' end FT of Rv1759c, len: 914 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 820 aa overlap). wag22, FT antigen member of the Mycobacterium tuberculosis PE family, FT PGRS subfamily of gly-rich proteins, highly similar to FT others e.g. MT1367|Q10637 hypothetical glycine-rich 49.6 kd FT protein from Mycobacterium tuberculosis (603 aa), FASTA FT scores: opt: 2010, E(): 0, (53.0% identity in 724 aa FT overlap); etc. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as FT a single gene. In Mycobacterium bovis, a single base FT deletion (c-*) splits wag22 into 2 parts, wag22a and FT wag22b." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:P0A687" FT /protein_id="CAD94491.1" FT /translation="MTPLLNSINAPVLAATGRPLIGNGANGAPGTGANGGDAGWLIGNG FT GAGGSGAKGANGGAGGPGGAAGLFGNGGAGGAGGTATANNGIGGAGGAGGSAMLFGAGG FT AGGAGGAATSLVGGIGGTGGTGGNAGMLAGAAGAGGAGGFSFSTAGGAGGAGGAGGLFT FT TGGVGGAGGQGHTGGAGGAGGAGGLFGAGGMGGAGGFGDHGTLGTGGAGGDGGGGGLFG FT AGGDGGAGGSGLTTGGAAGNGGNAGTLSLGAAGGAGGTGGAGGTVFGGGKGGAGGAGGN FT AGMLFGSGGGGGTGGFGFAAGGQGGVGGSAGMLSGSGGSGGAGGSGGPAGTAAGGAGGA FT GGAPGLIGNGGNGGNGGESGGTGGVGGAGGNAVLIGNGGEGGIGALAGKSGFGGFGGLL FT LGADGYNAPESTSPWHNLQQDILSFINEPTEALTGRPLIGNGDSGTPGTGDDGGAGGWL FT FGNGGNGGAGAAGTNGSAGGAGGAGGILFGTGGAGGAGGVGTAGAGGAGGAGGSAFLIG FT SGGTGGVGGAATTTGGVGGAGGNAGLLIGAAGLGGCGGGAFTAGVTTGGAGGTGGAAGL FT FANGGAGGAGGTGSTAGGAGGAGGAGGLYAHGGTGGPGGNGGSTGAGGTGGAGGPGGLY FT GAGGSGGAGGHGGMAGGGGGVGGNAGSLTLNASGGAGGSGGSSLSGKAGAGGAGGSAGL FT FYGSGGAGGNGGYSLNGTGGDGGTGGAGQITGLRSGFGGAGGAGGASDTGAGGNGGAGG FT KAGLYGNGGDGGAGGDGATSGKGGAGGNAVVIGNGGNGGNAGKAGGTAGAGGAGGLVLG FT RDGQHGLT" FT CDS complement(69133..69417) FT /transl_table=11 FT /gene="wag22a" FT /locus_tag="Mb1790c" FT /product="PE-PGRS FAMILY PROTEIN WAG22A [FIRST PART]" FT /note="Mb1790c, wag22a, len: 94 aa. Equivalent to 5' end of FT Rv1759c, len: 914 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 84 aa overlap). wag22, FT antigen member of the Mycobacterium tuberculosis PE family, FT PGRS subfamily of gly-rich proteins, highly similar to FT others e.g. MT1367|Q10637 hypothetical glycine-rich 49.6 kd FT protein from Mycobacterium tuberculosis (603 aa), FASTA FT scores: opt: 2010, E(): 0, (53.0% identity in 724 aa FT overlap); etc. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as FT a single gene. In Mycobacterium bovis, a single base FT deletion (c-*) splits wag22 into 2 parts, wag22a and FT wag22b." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZL8" FT /protein_id="CAD94492.1" FT /translation="MSFVIAVPETIAAAATDLADLGSTIAGANAAAAANTTSLLAAGAD FT EISAAIAALFGAHGRAYQAASAEAAAFHGRFVQALTTGGAPMRPPRPPP" FT CDS 69993..71522 FT /transl_table=11 FT /gene="Mb1791" FT /locus_tag="Mb1791" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1791, -, len: 509 aa. Equivalent to the 5' end of FT Rv1760, len: 502 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.5% identity in 442 aa overlap). Conserved FT hypothetical protein, similar to several other FT Mycobacterium tuberculosis hypothetical proteins e.g. FT Q10554|Y895_MYCTU|MTCY31.23 (505 aa), FASTA scores: opt: FT 692, E(): 0, (31.7% identity in 477 aa overlap). Member of FT family with at least 15 other members e.g. Rv3740c, FT Rv3734c, Rv1425, etc. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a frameshift due to a single base FT deletion (c-*) leads to a longer product with a different FT COOH part compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/TrEMBL:Q7TZL7" FT /protein_id="CAD94493.1" FT /translation="MPRGCAGARFACNACLNFLAGLGISEPISPGWAAMERLSGLDAFF FT LYMETPSQPLNVCCVLELDTSTMPGGYTYGRFHAALEKYVKAAPEFRMKLADTELNLDH FT PVWVDDDNFQIRHHLRRVAMPAPGGRRELAEICGYIAGLPLDRDRPLWEMWVIEGGARS FT DTVAVMLKVHHAVVDGVAGANLLSHLCSLQPDAPAPQPVRGTGGGNVLQIAASGLVGFA FT SRPVRLATVVPATVLTLVRTLLRAREGRTMAAPFSAPPTPFNGPLGRLRNIAYTQLDMR FT DVKRVKDRFGVTINDVVVALCAGALRRFLLEHGVLPEAPLVATVPVSVHDKSDRPGRNQ FT ATWMFCRVPSQISDPAQRIRTIAAGNTVAKDHAAAIGPTLLHDWIQFGGSTMFGAAMRI FT LPHISITHSPAYNLILSNVPGPQAQLYFLGCRMDSMFPLGPSLATRASTSPSCPSTGNW FT VSALSPAPTCCRTCGAWQTGFPRRSKSCWSAVMTSRKAATTRTPESYVQNR" FT CDS complement(71510..71893) FT /transl_table=11 FT /gene="Mb1792c" FT /locus_tag="Mb1792c" FT /product="HYPOTHETICAL EXPORTED PROTEIN" FT /note="Mb1792c, -, len: 127 aa. Equivalent to Rv1761c, len: FT 127 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 127 aa overlap). Possibly exported protein with FT hydrophobic stretch or TMhelix at aa 15-37." FT /db_xref="UniProtKB/TrEMBL:Q7TZL6" FT /protein_id="CAD94494.1" FT /translation="MSDFDTERVSRAVAAALVGPGGVALVVKVFAGLPGVIHTPARRGF FT FRSNPERIQIGDWRYEVAHDGRLLAAHMVNGIVIAEDALIAEAVGPHLARALGQIVSRY FT GATVIPNINAAIEVLGTGTDYRF" FT CDS complement(71893..72681) FT /transl_table=11 FT /gene="Mb1793c" FT /locus_tag="Mb1793c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1793c, -, len: 262 aa. Equivalent to Rv1762c, len: FT 262 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 262 aa overlap). Hypothetical unknown protein." FT /db_xref="InterPro:IPR002765" FT /db_xref="UniProtKB/TrEMBL:Q7TZL5" FT /protein_id="CAD94495.1" FT /translation="MQSSSLDPVASERLSHAEKSFTSDLSINEFALLHGAGFEPIELVM FT GVSVYHVGFQFSGMRQQQELGVLTEATYRARWNAMARMQAEADALKADGIVGVRLNWRH FT HGEGGEHLEFMAVGTAVRYTAKPGAFRRPNGQAFSSHLSGQDMVTLLRSGFAPVAFVMG FT NCVFHIAVQGFMQTLRQIGRNMEMPQWTQGNYQARELAMSRMQSEAERDGATGVVGVHF FT AISNYAWGVHTVEFYTAGTAVRRTGSGETITPSFVLPMDS" FT CDS complement(73699..74955) FT /transl_table=11 FT /gene="Mb1794c" FT /locus_tag="Mb1794c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1794c, -, len: 418 aa. Equivalent to Rv1765c, len: FT 365 aa, from Mycobacterium tuberculosis strain H37Rv, FT (97.8% identity in 364 aa overlap). Conserved hypothetical FT protein, highly similar to O53461|Rv2015c|MTV018.02c FT CONSERVED HYPOTHETICAL PROTEIN (418 aa), (97.8% identity in FT 364 aa overlap). BLAST hits with non-IS part of sequence FT submitted under MTU78639. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a 121 bp to 848 bp substitution FT affects the COOH part of Mb1794c leading to a longer FT product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (418 aa versus 365 aa)." FT /db_xref="GOA:Q7TZL4" FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:Q7TZL4" FT /protein_id="CAD94496.1" FT /translation="MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVAE FT LDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSLDQ FT VGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSADEQ FT FSCWRIKLPHVEAAKFDAALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAFLRLV FT EAGWDAEVARRPHGQHTTVVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEAWFERD FT GQVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGATELANLV FT LVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPPPAVAPWPGPTGE FT RADWWWYEPFQPQPPPISN" FT repeat_region 75024..75037 FT /rpt_type=INVERTED FT /note="14 bp imperfect inverted repeat, IRR, FT ATCACCCCGCAAAG, flanking IS element ISB9'." FT repeat_region complement(75024..76253) FT /mobile_element="insertion sequence:ISB9" FT /locus_tag="ISB9'" FT /note="ISB9', len: 1230 nt. Equivalent to ISB9', len: 1230 FT nt, from Mycobacterium tuberculosis strain H37Rv, (99.9% FT identity in 1230 nt overlap). Sequence ISB9, nearly FT identical to EM_BA:MTU78639. Note that this sequence shows FT several differences to EM_BA: MTU78639, and the transposase FT ORFs are extensively frameshi fted. Our sequence has been FT checked and is thought to be correct; the sequence in FT EM_BA:MTU78639 is from a different isolate of Mycobacterium FT tuberculosis." FT CDS complement(75582..75797) FT /transl_table=11 FT /gene="Mb1795c" FT /locus_tag="Mb1795c" FT /product="PUTATIVE TRANSPOSASE (FRAGMENT)" FT /note="Mb1795c, -, len: 71 aa. Equivalent to Rv1765A, len: FT 71 aa, from Mycobacterium tuberculosis strain H37Rv, (98.6% FT identity in 71 aa overlap). Putative transposase FT (fragment), similar to part of many transposase genes FT including IS6110 e.g. P19774|TRA9_MYCTU PUTATIVE FT TRANSPOSASE from Mycobacterium tuberculosis (278 aa), FASTA FT scores: opt: 231, E(): 4.7e-11, (45.35% identity in 75 aa FT overlap)." FT /db_xref="GOA:Q7TZL3" FT /db_xref="UniProtKB/TrEMBL:Q7TZL3" FT /protein_id="CAD94497.1" FT /translation="MWVADITFVRTWQGFCYTAFVTDVCTRKIVVRAVSATMRTEDLPV FT QVFNHAVWQSNSDLSELVHHSDPGSQ" FT CDS 76177..76446 FT /transl_table=11 FT /gene="Mb1795A" FT /locus_tag="Mb1795A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1795A, -, len: 89 aa. Equivalent to Rv1766, len: FT 89 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 89 aa overlap). Conserved hypothetical FT protein, highly similar to P54431|YRKD_BACSU Hypothetical FT 7.0 kDa protein in bltr-spoIIIC intergenic region from FT Bacillus subtilis (63 aa), FASTA scores: opt: 151, E(): FT 1.5e-05, (53.3% identity in 45 aa overlap). Also similar to FT Q9RD62|SCF56.04C|AL133424 Hypothetical protein from FT Streptomyces coelicolor (92 aa), FASTA scores: opt: 239, FT E(): 1.3e-11, (62.5% identity in 64 aa overlap). Also some FT similarity to other Mycobacterium tuberculosis hypothetical FT proteins e.g. O07434|Rv0190|MTCI28.29 (96 aa), (35.5% FT identity in 62 aa overlap); P71543|Rv0967 (119 aa), and FT P71600|Rv0030 (109 aa). Start changed since original FT submission." FT /db_xref="InterPro:IPR003735" FT /db_xref="UniProtKB/TrEMBL:Q7TZL2" FT /protein_id="CAD94498.1" FT /translation="MIGDQDSIAAVLNRLRRAQGQLAGVISMIEQGRDCRDVVTQLAAV FT SRALDRAGFKIVAAGLKECVSGATASGAAPLSAAELEKLFLALA" FT repeat_region complement(76240..76253) FT /rpt_type=INVERTED FT /note="14 bp imperfect inverted repeat, IRL, FT ATCACCCCGGCAAG, flanking IS element ISB9'." FT CDS 76514..76873 FT /transl_table=11 FT /gene="Mb1796" FT /locus_tag="Mb1796" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1796, -, len: 119 aa. Equivalent to Rv1767, len: FT 119 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 119 aa overlap). Conserved hypothetical FT protein, similar to Q57498|YA53_HAEIN HYPOTHETICAL PROTEIN FT HI1053 from Haemophilus influenzae (113 aa), FASTA scores: FT opt: 233, E(): 6.4e-10, (40.0% identity in 90 aa overlap)." FT /db_xref="InterPro:IPR003779" FT /db_xref="UniProtKB/TrEMBL:Q7TZL1" FT /protein_id="CAD94499.1" FT /translation="MSDQPRHHQVLDDLLPQHRALRHQIPQVYQRFVALGDAALTDGAL FT SRKVKELVALAIAVVQGCDGCVASHAQAAVRAGATAQEAAEAIGVTILMHGGPATIHGA FT RAYAAFCEFADTTPS" FT CDS 77054..78928 FT /transl_table=11 FT /gene="PE_PGRS31" FT /locus_tag="Mb1797" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1797, PE_PGRS31, len: 624 aa. Equivalent to FT Rv1768, len: 618 aa, from Mycobacterium tuberculosis strain FT H37Rv, (98.88% identity in 624 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, highly similar to Q50615 HYPOTHETICAL FT 40.8 KD PROTEIN (498 aa), FASTA scores: opt: 1703, E(): 0, FT (57.4% identity in 566 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 18 FT bp insertion, leads to a longer product compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv (624 aa FT versus 618 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZL0" FT /protein_id="CAD94500.1" FT /translation="MSYLVVVPELVAAAATDLANIGSSISAANAAAAAPTTALVAAGGD FT EVSAAIAALFGAHARAYQALSAQAAMFHEQFVRALAAGGNSYAVAEAATAQSVQQDLLN FT LINAPTQALLGRPLIGNGANGLPGTGQNGGDGGILYGNGGNGGSGGVNQAGGNGGNAGL FT WGNGGSGGAGGNATTAGRNGFNGGAGGSGGLLWGNGGAGGAGGHGGPAPLVGGVGTTGG FT AGGNGGGAGLFYGFGGAGGNGGMGGVAPSTGPSMGILPAGGVGGPGGSGGASALAFGSG FT GVGGAGGLGGPTDGTVQGVGGFGGQGGNGGQSGLLFGNAGAGGAGAAGGAGTGDTESFG FT GHGGAGGDGGAVGLIGNGGGGGNGGAGGTGSPGAVVGGNGGVGGLGGAGSPGGLLYGTG FT GAGGNGGPGGDGGTGATVGFAGSGGFGGAGGIAQLFGTGGMGGSGGGIGAGTTTVVPPD FT VAPVGGTGGNGGRAGLLLGVGGMGGNGGATSVGGTLYAAGGNGGDGGLVWGNGGTGGSG FT GAGGAGSVGNGGAGGNAALLFGNGGAGGAGGAGGIGAGGAGGFGAVLFGNGGAGGSGAP FT GGIGAGGNGGNALLVGNGGNGGAGTGGAAGGAGGSGGLLFGQNGMPGP" FT CDS 79084..80328 FT /transl_table=11 FT /gene="Mb1798" FT /locus_tag="Mb1798" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1798, -, len: 414 aa. Equivalent to Rv1769, len: FT 414 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 414 aa overlap). Conserved hypothetical FT protein, similar to O88066|SCI35.31|AL031541 hypothetical FT protein from Streptomyces coelicolor (402 aa), FASTA FT scores: opt: 1341, E(): 0, (53.8% identity in 398 aa FT overlap)." FT /db_xref="InterPro:IPR001608" FT /db_xref="UniProtKB/TrEMBL:Q7TZK9" FT /protein_id="CAD94501.1" FT /translation="MHEVAAREQRSDGPMRLDAQGRLQRYEEAFADYDAPFAFVDLDAM FT WGNADQLLARAGDKPIRVASKSLRCRPLQREILDASERFDGLLTFTLTETLWLAGQGFS FT NLLLAYPPTDRAALRALGELTAKDPDGAPIVMVDSVEHLDLIERTTDKPVRLCLDFDAG FT YWRAGGRIKIGSKRSPLHTPEQARALAVEIARRPALTLAALMCYEAHIAGLGDNVAGKR FT VHNAIIRRMQRMSFEELRERRARAVELVREVADIKIVNAGGTGDLQLVAQEPLITEATA FT GSGFYAPTLFDSYSTFTLQPAAMFALPVCRRPGAKTVTALGGGYLASGVGAKDRMPTPY FT LPVGLKLNALEGTGEVQTPLSGDAARRLKLGDKVYFRHTKAGELCERFDHLHLVRGAEV FT VDTVPTYRGEGRTFL" FT CDS 80336..81622 FT /transl_table=11 FT /gene="Mb1799" FT /locus_tag="Mb1799" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1799, -, len: 428 aa. Equivalent to Rv1770, len: FT 428 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 428 aa overlap). Conserved hypothetical FT protein, highly similar in N-terminus to Q49882 FT Hypothetical protein from Mycobacterium leprae from cosmid FT L247 (83 aa), FASTA scores: opt: 301, E(): 1e-12, (56.5% FT identity in 85 aa overlap)." FT /db_xref="InterPro:IPR000276" FT /db_xref="UniProtKB/TrEMBL:Q7TZK8" FT /protein_id="CAD94502.1" FT /translation="MDEAHPAHPADAGRPGGPIQGARRGAAMTPITALPTELAAMREVV FT ETLAPIERAAGEPGEHKAAEWIVERLRTAGAQDARIEEEQYLDGYPRLHLKLSVIGVAA FT GVAGLLSRRLRIPAALAGVGAGLAIADDCANGPRIVRKRTETPRTTWNAVAEAGDPAGQ FT LTVVVCAHHDAAHSGKFFEAHIEEVMVELFPGIVERIDTQLPNWWGPILAPALAGVGAL FT RGSRPMMIAGTVGSALAAALFADIARSPVVPGANDNLSAVALLVALAERLRERPVKGVR FT VLLVSLGAEETLQGGIYGFLARHKPELDRDRTYFLNFDTIGSPELIMLEGEGPTVMEDY FT FYRPFRDLVIRAAERADAPLRRGIRSRNSTDAVLMSRAGYPTACFVSINRHKSVANYHL FT MSDTPENLCYETVSHAVTVAESVIRELAR" FT CDS 81619..82905 FT /transl_table=11 FT /gene="Mb1800" FT /locus_tag="Mb1800" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1800, -, len: 428 aa. Equivalent to Rv1771, len: FT 428 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 428 aa overlap). Probable FT oxidoreductase (EC 1.-.-.-), similar to e.g. FT GGLO_RAT|P10867 l-gulonolactone oxidase (ec 1.1.3.8) (439 FT aa), FASTA scores: opt: 862, E(): 0, (34.1% identity in 434 FT aa overlap). Also shows slight similarity to Mycobacterium FT tuberculosis oxidoreductase Rv1726|MTCY04C12.11 (22.9% FT identity in 441 aa overlap) and others e.g. Rv3107c, FT Rv1257c, Rv2251, etc. Contains PS00862 Oxygen FT oxidoreductases covalent FAD-binding site." FT /db_xref="GOA:Q7TZK7" FT /db_xref="InterPro:IPR006094" FT /db_xref="UniProtKB/TrEMBL:Q7TZK7" FT /protein_id="CAD94503.1" FT /translation="MSPIWSNWPGEQVCAPSAIVRPTSEAELADVIAQAAKRGERVRAV FT GSGHSFTDIACTDGVMIDMTGLQRVLDVDQPTGLVTVEGGAKLRALGPQLAQRRLGLEN FT QGDVDPQSITGATATATHGTGVRFQNLSARIVSLRLVTAGGEVLSLSEGDDYLAARVSL FT GALGVISQVTLQTVPLFTLHRHDQRRSLAQTLERLDEFVDGNDHFEFFVFPYADKALTR FT TMHRSDEQPKPTPGWQRMVGENFENGGLSLICQTGRRFPSVAPRLNRLMTNMMSSSTVQ FT DRAYKVFATQRKVRFTEMEYAIPRENGREALQRVIDLVRRRSLPIMFPIEVRFSAPDDS FT FLSTAYGRDTCYIAVHQYAGMEFESYFRAVEEIMDDYAGRPHWGKRHYQTAATLRERYP FT QWDRFAAVRDRLDPDRVFLNDYTRRVLGP" FT CDS 83094..83405 FT /transl_table=11 FT /gene="Mb1801" FT /locus_tag="Mb1801" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1801, -, len: 103 aa. Equivalent to Rv1772, len: FT 103 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 103 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR005561" FT /db_xref="UniProtKB/TrEMBL:Q7TZK6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94504.1" FT /translation="MGSTGGSQPMTANRGPAAISSGSNSGRVLDTARGILIALRRCPAE FT TAFDELHNAAQRHRLPVFEIAWALVHLAVEGSTPCRSFVDAQSAARREWGQLFAHAAA" FT CDS complement(83478..84224) FT /transl_table=11 FT /gene="Mb1802c" FT /locus_tag="Mb1802c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1802c, -, len: 248 aa. Equivalent to Rv1773c, len: FT 248 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 248 aa overlap). Probable FT transcriptional regulator belonging to IclR family, similar FT to ICLR_ECOLI|P16528 acetate operon repressor from FT Escherichia coli (274 aa), FASTA scores: opt: 261, E(): FT 3.3e-10, (26.9% identity in 249 aa overlap). Also similar FT to Mycobacterium tuberculosis protein Rv1719|MTCY04C12.04 FT (40.2% identity in 244 aa overlap); and Rv2989. Start site FT chosen by homology, but may extend further upstream. FT Contains possible helix-turn-helix motif at aa 37-58 (+3.24 FT SD)." FT /db_xref="GOA:Q7TZK5" FT /db_xref="InterPro:IPR005471" FT /db_xref="UniProtKB/TrEMBL:Q7TZK5" FT /protein_id="CAD94505.1" FT /translation="MPPTEGKSTTNRDEGIQVLRRAVAALDEIAAEPGHLRLVDLCERL FT GLAKSTTRRLLVGLVEVGLVSVDSHGRFALGERLLGFGSVTGAHIAAAFRPTVERVARA FT TDGETVDLSVLRGQRMWFVDQIESSYRLRAVSAVGLRFPLNGTANGKAALAALDDADAE FT AALCRLDPMVAEGLRREIVEIRRTGIAFDRNEHTPGISAAAIARRALGDNVIAISVPAP FT TARFLEKEQRIIAALRAAADSPDWTR" FT CDS 84290..85630 FT /transl_table=11 FT /gene="Mb1803" FT /locus_tag="Mb1803" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1803, -, len: 446 aa. Equivalent to Rv1774, len: FT 446 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 446 aa overlap). Probable FT oxidoreductase (EC 1.-.-.-), similar to several e.g. FT HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa), FT FASTA scores: opt: 417, E(): 6e-20, (28.4% identity in 462 FT aa overlap). Also some similarity to Mycobacterium FT tuberculosis oxidoreductase MTCY04C12.11 (24.1% identity in FT 444 aa overlap). Contains PS00862 Oxygen oxidoreductases FT covalent FAD-binding site." FT /db_xref="GOA:Q7TZK4" FT /db_xref="InterPro:IPR006094" FT /db_xref="UniProtKB/TrEMBL:Q7TZK4" FT /protein_id="CAD94506.1" FT /translation="MRALPAGRHFFRGSDGYEAARRGTVWHRRVPDRYPEVIVQAVSAD FT DIVSAIRYATVNGHKVSVVSGGHSFAASHLRDGAVLLDVSRIDHASIDADKGRAVVGPG FT KGGSVLMAELEAQGLFFPGGHCRGVCLGGYLLQGGYGWNSRIYGPACESVIGLDVITAD FT GAQIHCDADNHADLYWAARGAGPGFFGVVTSFYLKLYPRPATCGTSVYVYPFDLADEVF FT TWARAVSAEVDPRVELQALASRGEPSMGIDVPVISLASPAFADSPEEAEQALALFGTCP FT VVEQALVKVPYMPTDLPAWYDVAMTHYLSDHHYAVDNMWTSASAEDLLPGIRSILDTLP FT PHPAHFLWLNWGPCPPRQDMAYSIEADIYLALYGSWKDPADEAKYADWARSHMAAMSHL FT AVGIQLADENLGARPARFASDAAMAKLDRVRAEYDPDGLFNSWMGRI" FT CDS 85630..86448 FT /transl_table=11 FT /gene="Mb1804" FT /locus_tag="Mb1804" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1804, -, len: 272 aa. Equivalent to Rv1775, len: FT 272 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 272 aa overlap). Conserved hypothetical FT protein, similar to O28806|AF1466 CONSERVED HYPOTHETICAL FT PROTEIN from Archaeoglobus fulgidus (255 aa), FASTA scores: FT opt: 364, E(): 1e-17, (29.2% identity in 267 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZK3" FT /protein_id="CAD94507.1" FT /translation="MASDLYLGYRNDDADTPFGKFFKPEMAPLPQHVVVALQHGPQAGM FT ALLAFDDAASIVDEGYQQTENGYGILGDGSMQVSVRTDMPGVTPAMWAWWFGWHGSDTR FT RYKLWHPRAHLSARWKDGDQDSGAGRRGAQRYVGRWSMISEYIGSTKLGAAIQFVEPAA FT MGLPDDSDDTVSICARLGSADAPVDAGWFVHQVRSTPGGSEMRSRFWMGGPHIAVRKAP FT EVASKAVRPIASKLIGVSESTARNLLVYCAQEMNHLAGFLADLWESFGDE" FT CDS complement(86453..87013) FT /transl_table=11 FT /gene="Mb1805c" FT /locus_tag="Mb1805c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1805c, -, len: 186 aa. Equivalent to Rv1776c, len: FT 186 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 186 aa overlap). Possible regulatory FT protein, some similarity to Mycobacterium tuberculosis FT Rv1255c|Q11063 hypothetical transcriptional regulator (202 FT aa), FASTA scores: opt: 270, E( ): 9.7e-09, (28.3% identity FT in 191 aa overlap) . Contains possible helix-turn-helix FT motif at aa 37-58 (+3.49 SD)." FT /db_xref="GOA:Q7TZK2" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7TZK2" FT /protein_id="CAD94508.1" FT /translation="MPGNDWIVGGNRRTIAAERIYAAATDLITRYGLNALDIDKLAREV FT HCSRATIYRRAGGKAQIRDVVLTRAAARIADGVRSDVETLRGRERVVAAILLSLQRIRS FT DPLGKLMFGSIHGGAGELAWLTESPLLADFATELTGIAGGDPQGAKWVVRVVLSLMYWP FT AENDEAERRLVEKYVAPAFAEQS" FT CDS 87114..88418 FT /transl_table=11 FT /gene="cyp144" FT /locus_tag="Mb1806" FT /product="Probable cytochrome p450 144 CYP144" FT /EC_number="1.14.-.-" FT /note="Mb1806, cyp144, len: 434 aa. Equivalent to Rv1777, FT len: 434 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 434 aa overlap). Probable cyp144, FT cytochrome p450 (EC 1.14.-.-), similar to CPXM_BACME|Q06069 FT cytochrome p450 (meg) (EC 1.14.99.-) (410 aa), FASTA FT scores: opt: 435 E(): 2.3e-16, (28.8% identity in 372 aa FT overlap). Also similar to several other Mycobacterium FT tuberculosis p450 genes including Rv0766c, Rv2266, etc. FT Contains PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:Q7VET9" FT /db_xref="HSSP:1IO7" FT /db_xref="InterPro:IPR002397" FT /db_xref="UniProtKB/TrEMBL:Q7VET9" FT /protein_id="CAD94509.1" FT /translation="MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAES FT VQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGT FT AKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGM FT QDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGV FT ALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAA FT LLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGQYRHVRNATTLDGTELP FT ADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVL FT RLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ" FT CDS complement(88539..88988) FT /transl_table=11 FT /gene="Mb1807c" FT /locus_tag="Mb1807c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1807c, -, len: 149 aa. Equivalent to Rv1778c, len: FT 149 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 149 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZK1" FT /protein_id="CAD94510.1" FT /translation="MRVSLFLSDAAQADAQSGKVHALGLGWRQCQRPTPPFALVLFLDI FT DWDETNKQHQLKCQLLTADGDPVVVPGPHGPQRILFEAAAEAGRAPGAIHGTSVRMPLT FT LNIPAGIPLEPGIYEWRVEVEGYERATAVEAFIVAGGGHPPASCG" FT CDS complement(89144..90937) FT /transl_table=11 FT /gene="Mb1808c" FT /locus_tag="Mb1808c" FT /product="HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN" FT /note="Mb1808c, -, len: 597 aa. Equivalent to Rv1779c, len: FT 597 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 597 aa overlap). Possible integral FT membrane protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZK0" FT /protein_id="CAD94511.1" FT /translation="MCAHEYAEQRSAVSGIEGLLTWLGGGHWRELGERHERSTHAVAGV FT IVAVGAALAGLLASLAVSEAAQGPISSPIGAASLALVLGLLVGAVTRGTASGPARGRAG FT VTGRASVAVAVGFVVGELAALVMFSGAIDRRLDEQAMHSADATPAAVQASASLQQARNA FT RTALDSAVERARGRLDDALVVARCEYHPTPACPQTRITGVPGRGPETRTANQLLADAQR FT ELDNALAARDHQAPALDAKMAHDEQALAEVRQAVVADAGRGLGSRWVAMNDLTLASAGA FT LTARMLAIAFFALLYLLPLILRLWRGDTTHDRHAAARAERERAELEADTAIAIKRAEVR FT RAAEIMWAEHQLTQTRLAIEAQAEIDREQQRRRVVEALEGPVRASSERTLQPVEDEVYL FT PIAAETEAASRTVAQLPAGAAHHRPGIAKNLPAQVQPEGAVEPREKRATPVIRSIPDAT FT KAAARWIRPLVPPFVARMLDNTTAPLRTARQVFEEVEEIAFSFKRTHKVTVNAEGSDPN FT DQPPLESHSPAAPAESNPIASSDSARRSRLATNDDHPPLAQVPPRDLASLSVGSTGELT FT QREGPHELRSPDGPRQLPPPR" FT CDS 91157..91720 FT /transl_table=11 FT /gene="Mb1809" FT /locus_tag="Mb1809" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1809, -, len: 187 aa. Equivalent to Rv1780, len: FT 187 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 187 aa overlap). Conserved hypothetical FT protein, equivalent to Q49881|ML1380|U00021_2 cosmid L247 FT from Mycobacterium leprae (187 aa), FASTA scores: opt: FT 1000, E(): 0, (82.4% identity in 187 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZJ9" FT /protein_id="CAD94512.1" FT /translation="MQNHDYVTYEEFGRRFFEVAVTPDRVAAAFADIAGSEFAMEPISQ FT GPGGIAKVSANVKIREPRVTRKLGDLITFVIHIPLSIDLLLDLRLDKQRFMVAGDIALR FT ATARAAEPLLLIVDVAKPRPSDITVNVSSKSIRGEVLRILAGVDGEIRRFIAQYVSAEI FT DSPKSQAAQVINVAEQLDSTWSGP" FT CDS complement(91760..93934) FT /transl_table=11 FT /gene="malQ" FT /locus_tag="Mb1810c" FT /product="PROBABLE 4-ALPHA-GLUCANOTRANSFERASE MALQ FT (Amylomaltase) (Disproportionating enzyme) (D-enzyme)" FT /EC_number="2.4.1.25" FT /note="Mb1810c, malQ, len: 724 aa. Equivalent to Rv1781c, FT len: 724 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 724 aa overlap). Probable malQ, FT 4-ALPHA-GLUCANOTRANSFERASE (EC 2.4.1.25), similar to many, FT e.g. P15977|MALQ_ECOLI 4-ALPHA-GLUCANOTRANSFERASE (694 aa), FT FASTA scores: opt: 964, E(): 0, (31.8% identity in 694 aa FT overlap). BELONGS TO THE DISPROPORTIONATING ENZYME FAMILY." FT /db_xref="GOA:P65337" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/Swiss-Prot:P65337" FT /protein_id="CAD94513.1" FT /translation="MTELAPSLVELARRFGIATEYTDWTGRQVLVSEATLVAALAALGV FT PAQTEQQRNDALAAQLRSYWARPLPATIVMRAGEQTQFRVHVTDGAPADVWLQLEDGTT FT RAEVVQVDNFTPPFDLDGRWIGEASFVLPADLPLGYHRVNLRSGDSQASAAVVVTPDWL FT GLPDKLAGRRAWGLAVQLYSVRSRQSWGIGDLTDLANLALWSASAHGAGYVLVNPLHAA FT TLPGPAGRSKPIEPSPYLPTSRRFVNPLYLRVEAIPELVDLPKRGRVQRLRTNVQQHAD FT QLDTIDRDSAWAAKRAALKLVHRVPRSAGRELAYAAFRTREGRALDDFATWCALAETYG FT DDWHRWPKSLRHPDASGVADFVDKHADAVDFHRWLQWQLDEQLASAQSQALRAGMSLGI FT MADLAVGVHPNGADAWALQDVLAQGVTAGAPPDEFNQLGQDWSQPPWRPDRLAEQEYRP FT FRALIQAALRHAGAVRIDHIIGLFRLWWIPDGAPPTQGTYVRYDHDAMIGIVALEAHRA FT GAVVVGEDLGTVEPWVRDYLLLRGLLGTSILWFEQDRDCGPAGTPLPAERWREYCLSSV FT TTHDLPPTAGYLAGDQVRLRESLGLLTNPVEAELESARADRAAWMAELRRVGLLADGAE FT PDSEEAVLALYRYLGRTPSRLLAVALTDAVGDRRTQNQPGTTDEYPNWRVPLTGPDGQP FT MLLEDIFTDRRAATLAEAVRAATTSPMSCW" FT CDS 94198..95718 FT /transl_table=11 FT /gene="Mb1811" FT /locus_tag="Mb1811" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb1811, -, len: 506 aa. Equivalent to Rv1782, len: FT 506 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 506 aa overlap). Probable conserved FT membrane protein, similar to four other Mycobacterium FT tuberculosis hypothetical membrane proteins e.g. FT O05449|Rv3895c|MTCY15F10.17|Z94121 (495 aa), FASTA scores: FT opt: 1106, E(): 0, (41.2% identity in 485 aa overlap); FT Rv0283, Rv3450c, and Rv3869, all located near ESAT-6 family FT genes. Also similar to O33088|MLCB628.17C|Y14967 cosmid FT B628 from Mycobacterium leprae (481 aa), (32.7% identity in FT 486 aa overlap); and equivalent to FT Q9Z5I3|MLCB596.27|AL035472 hypothetical protein from FT Mycobacterium leprae (506 aa) (82.6% identity in 506 aa FT overlap). Has hydrophobic stretch from aa 54-76." FT /db_xref="InterPro:IPR007795" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ8" FT /protein_id="CAD94514.1" FT /translation="MAEESRGQRGSGYGLGLSTRTQVTGYQFLARRTAMALTRWHVRME FT IEPGRRQTLAVVASVSAALVICLGALLWSFISPSGQLNESPIIADRDSGALYVRVGDRL FT YPALNLASARLITGRPDNPHLVRSSQIATMPRGPLVGIPGAPSSFSPKSPPASSWLVCD FT TVATSSSIGSLQGVTVTVIDGTPDLTGHRQILSGSDAVVLRYGGDAWVIREGRRSRIEP FT TNRAVLLPLGLTPEQVSQARPMSRALFDALPVGPELLVPEVPNAGGPATFPGAPGPIGT FT VIVTPQISGPQQYSLVLGDGVQTLPPLVAQILQNAGSAGNTKPLTVEPSTLAKMPVVNR FT LDLSAYPDNPLEVVDIREHPSTCWWWERTAGENRARVRVVSGPTIPVAATEMNKVVSLV FT KADTSGRQADQVYFGPDHANFVAVTGNNPGAQTSESLWWVTDAGARFGVEDSKEARDAL FT GLTLTPSLAPWVALRLLPQGPTLSRADALVEHDTLPMDMTPAELVVPK" FT CDS 95715..99890 FT /transl_table=11 FT /gene="Mb1812" FT /locus_tag="Mb1812" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb1812, -, len: 1391 aa. Similar to Rv1783 and FT Rv1784, len: 435 aa and 932 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 435 aa FT overlap and 99.9% identity in 932 aa overlap). Rv1783: FT Probable conserved membrane protein. Member of family of FT Mycobacterium tuberculosis hypothetical proteins including FT O05450|Rv3894c|MTY15F10.18|Z94121 (1396 aa), FASTA scores: FT opt: 542, E(): 1.5e-26, (31.4% identity in 440 aa overlap); FT Rv3447c, Rv0284, Rv3870, Rv1784, and Rv3871, all linked to FT ESAT-6 family gene. Similar to N-terminal part of Rv3894c FT (1396 aa), Rv1784 is similar to remainder of Rv3894c. Also FT similar to O33087|MLCB628.16C|Y14967 Hypothetical protein FT from Mycobacterium leprae (744 aa), (30.0% identity in 437 FT aa overlap) and equivalent to N-terminal part of FT Q9Z5I2|MLCB596.28|AL035472 hypothetical protein from FT Mycobacterium leprae (1345 aa), (86.4% identity in 397 aa FT overlap). Rv1784: Conserved hypothetical protein, member of FT family of Mycobacterium tuberculosis hypothetical proteins FT including Rv3447c, Rv0284, Rv3870, Rv1783, Rv3871, Rv3894c, FT all linked to ESAT-6 family genes. Probably ATP-binding FT membrane proteins. Similar to C-terminal region of FT 006264|Rv3447c (1236 aa), (36.2% identity in 930 aa FT overlap). Equivalent to C-terminal region of Mycobacterium FT leprae hypothetical protein Q9Z512|MLCB596.28|AL035472 FT (1345 aa), (87.8% identity in 932 aa overlap); also similar FT to other hypothetical proteins e.g. MLCB628.14 from FT Mycobacterium leprae, (32.0% identity in 600 aa overlap); FT MLCB628.15 from Mycobacterium leprae, (35.0% identity in FT 280 aa overlap); and O86653|SC3C3.20|AL031231 ATP/GTP FT binding protein from Streptomyces coelicolor (1321 aa), FT FASTA scores: opt: 618, E(): 4.6e-30, (34.3% identity in FT 937 aa overlap). Contains two times PS00017 ATP/GTP-binding FT site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 FT exist as 2 genes. In Mycobacterium bovis, a single base FT transversion (a-t) leads to a single product." FT /db_xref="GOA:Q7TZJ7" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ7" FT /protein_id="CAD94515.1" FT /translation="MKRGFARPTPEKPPVIKPENIVLSTPLSIPPPEGKPWWLIVVGVV FT VVGLLGGMVAMVFASGSHVFGGIGSIFPLFMMVGIMMMMFRGMGGGQQQMSRPKLDAMR FT AQFMLMLDMLRETAQESADSMDANYRWFHPAPNTLAAAVGSPRMWERKPDGKDLNFGVV FT RVGVGMTRPEVTWGEPQNMPTDIELEPVTGKALQEFGRYQSVVYNLPKMVSLLVEPWYA FT LVGEREQVLGLMRAIICQLAFSHGPDHVQMIVVSSDLDQWDWVKWLPHFGDSRRHDAAG FT NARMVYTSVREFAAEQAELFAGRGSFTPRHASSSAQTPTPHTVIIADVDDPQWEYVISA FT EGVDGVTFFDLTGSSMWTDIPERKLQFDKTGVIEALPRDRDTWMVIDDKAWFFALTDQV FT SIAEAEEFAQKLAQWRLAEAYEEIGQRVAHIGARDILSYYGIDDPGNIDFDSLWASRTD FT TMGRSRLRAPFGNRSDNGELLFLDMKSLDEGGDGPHGVMSGTTGSGKSTLVRTVIESLM FT LSHPPEELQFVLADLKGGSAVKPFAGVPHVSRIITDLEEDQALMERFLDALWGEIARRK FT AICDSAGVDDAKEYNSVRARMRARGQDMAPLPMLVVVIDEFYEWFRIMPTAVDVLDSIG FT RQGRAYWIHLMMASQTIESRAEKLMENMGYRLVLKARTAGAAQAAGVPNAVNLPAQAGL FT GYFRKSLEDIIRFQAEFLWRDYFQPGVSIDGEEAPALVHSIDYIRPQLFTNSFTPLEVS FT VGGPDIEPVVAQPNGEMLESDDIEGGEDEDEEGVRTPKVGTVIIDQLRKIKFEPYRLWQ FT PPLTQPVAIDDLVNRFLGRPWHKEYGSACNLVFPIGIIDRPYKHDQPPWTVDTSGPGAN FT VLILGAGGSGKTTALQTLICSAALTHTPQQVQFYCLAYSSTALTTVSRIPHVGEVAGPT FT DPYGVRRTVAELLALVRERKRSFLECGIASMEMFRRRKFGGEAGPVPDDGFGDVYLVID FT NYRALAEENEVLIEQVNVIINQGPSFGVHVVVTADRESELRPPVRSGFGSRIELRLAAV FT EDAKLVRSRFAKDVPVKPGRGMVAVNYVRLDSDPQAGLHTLVARPALGSTPDNVFECDS FT VVAAVSRLTSAQAPPVRRLPARFGVEQVRELASRDTRQGVGAGGIAWAISELDLAPVYL FT NFAENSHLMVTGRRECGRTTTLATIMSEIGRLYAPGASSAPPPAPGRPSAQVWLVDPRR FT QLLTALGSDYVERFAYNLDGVVAMMGELAAALAGREPPPGLSAEELLSRSWWSGPEIFL FT IVDDIQQLPPGFDSPLHKAVPFVNRAADVGLHVIVTRTFGGWSSAGSDPMLRALHQANA FT PLLVMDADPDEGFIRGKMKGGPLPRGRGLLMAEDTGVFVQVAATEVRR" FT CDS complement(99905..101086) FT /transl_table=11 FT /gene="cyp143" FT /locus_tag="Mb1813c" FT /product="PROBABLE CYTOCHROME P450 143 CYP143" FT /EC_number="1.14.-.-" FT /note="Mb1813c, cyp143, len: 393 aa. Equivalent to Rv1785c, FT len: 393 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 393 aa overlap). Probable cyp143, FT cytochrome P450 (1.14.-.-), similar to many e.g. FT AE0001|RZAE000101_4 Rhizobium sp. NGR234 (414 aa), FASTA FT scores: opt: 663, E(): 0, (32.4% identity in 413 aa FT overlap). Contains PS00086 Cytochrome P450 cysteine FT heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FT FAMILY." FT /db_xref="GOA:P63724" FT /db_xref="HSSP:1IO7" FT /db_xref="InterPro:IPR017972" FT /db_xref="UniProtKB/Swiss-Prot:P63724" FT /protein_id="CAD94516.1" FT /translation="MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFMN FT GWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYFSP FT AALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGW FT KDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLSEIEV FT LGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPV FT APRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWGFGGGPH FT RCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS" FT CDS 101286..101489 FT /transl_table=11 FT /gene="Mb1814" FT /locus_tag="Mb1814" FT /product="PUTATIVE FERREDOXIN" FT /EC_number="1.-.-.-" FT /note="Mb1814, -, len: 67 aa. Equivalent to Rv1786, len: 67 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 67 aa overlap). Probable ferredoxin (EC FT 1.-.-.-), similar to others e.g. X63601|FERS_STRGR FT FERREDOXIN from Streptomyces griseus (65 aa), FASTA scores: FT opt: 140, E(): 0.001, (38.1% identity in 63 aa overlap); FT T50943 probable ferredoxin DitA from Pseudomonas FT abietaniphila (78 aa); BAA84714.1|AB017795 ferredoxin from FT Nocardioides sp. (69 aa); etc. Also similar to FT Rv0763c|MTCY369.08 from Mycobacterium tuberculosis (68 aa), FT FASTA score: (30.6% identity in 62 aa overlap); and FT Rv0763c." FT /db_xref="GOA:Q7TZJ6" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ6" FT /protein_id="CAD94517.1" FT /translation="MKVRLDPSRCVGHAQCYAVDPDLFPIDDSGNSILAEHEVRPEDMQ FT LTRDGVAACPEMALILEEDDAD" FT CDS 101759..102853 FT /transl_table=11 FT /gene="PPE25" FT /locus_tag="Mb1815" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1815, PPE25, len: 364 aa. Equivalent to Rv1787, FT len: 365 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 365 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, similar to Z74024|MTCY274.24 Mycobacterium FT tuberculosis cosmid (404 aa), FASTA scores: opt: 837, E(): FT 0, (52.0% identity in 406 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 8 FT bp to 5 bp substitution (agcccggt-ccggg), leads to a FT slightly shorter product compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 FT aa)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ5" FT /protein_id="CAD94518.1" FT /translation="MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGY FT ASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMT FT VPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQYAEMWAQDAVAMYGYAAASASASR FT LIPFAAPPKTTNSAGVVAQVAAVAAMPGLLQRLSSAASVSWSNPNDWWLVRLLGSITPT FT ERTTIVRLLGQSYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGASRAV FT SASLARANKIGALSVPPSWVKTTALTEPGAHAVSANPTVGSSHGPHGLLRGLPLGSRIT FT RRSGAFAHRYGFRHSVVARPPSAG" FT CDS 102932..103231 FT /transl_table=11 FT /gene="PE18" FT /locus_tag="Mb1816" FT /product="PE FAMILY PROTEIN" FT /note="Mb1816, PE18, len: 99 aa. Equivalent to Rv1788, len: FT 99 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 99 aa overlap). Member of the FT Mycobacterium tuberculosis PE family of gly-, ala-rich FT proteins, similar to Z93777|MTCI364.07 Mycobacterium FT tuberculosis cosmid (99 aa), FASTA scores: opt: 414, E(): FT 3.6e-20, (72.4% identity in 98 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ4" FT /protein_id="CAD94519.1" FT /translation="MSFVTTQPEALAAAAGSLQGIGSALNAQNAAAATPTTGVVPAAAD FT EVSALTAAQFAAHAQIYQAVSAQAAAIHEMFVNTLQMSSGSYAATEAANAAAAG" FT CDS 103245..104426 FT /transl_table=11 FT /gene="PPE26" FT /locus_tag="Mb1817" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1817, PPE26, len: 393 aa. Equivalent to Rv1789, FT len: 393 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 393 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, highly similar to others e.g.Z98268|MTCI125.26 FT Mycobacterium tuberculosis cosmid (385 aa), FASTA score: FT opt: 1283, E(): 0, (62.7% identity in 408 aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ3" FT /protein_id="CAD94520.1" FT /translation="MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAELSSAATGY FT ETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAATQARAAAAAFEAAFAAT FT VPPPLIAANRASLMQLISTNVFGQNTSAIAAAEAQYGEMWAQDSAAMYAYAGSSASASA FT VTPFSTPPQIANPTAQGTQAAAVATAAGTAQSTLTEMITGLPNALQSLTSPLLQSSNGP FT LSWLWQILFGTPNFPTSISALLTDLQPYASFFYNTEGLPYFSIGMGNNFIQAAKTLGLI FT GSAAPAAVAAAGDAAKGLPGLGGMLGGGPVAAGLGNAASVGKLSVPPVWSGPLPGSVTP FT GAAPLPVSTVSAAPEAAPGSLLGGLPLAGAGGAGAGPRYGFRPTVMARPPFAG" FT CDS 104880..105932 FT /transl_table=11 FT /gene="PPE27" FT /locus_tag="Mb1818" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1818, PPE27, len: 350 aa. Equivalent to Rv1790, FT len: 350 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 350 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT protein, similar to Z74024|MTCY274.24 Mycobacterium FT tuberculosis cosmid (404 aa), FASTA scores: opt: 849, E(): FT 0, (50.0% identity in 406 aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ2" FT /protein_id="CAD94521.1" FT /translation="MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGY FT ASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMT FT VPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQYAEMWAQDAVAMYGYAAASASASR FT LIPFAAPPKTTNSAGVVAQAVASVSWSNPNDWWLVRLLGSITPTERTTIVRLLGQSYLA FT TGMARFLTSIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGAGPAVSASLARAEPVGRLSV FT PPSWAVAAPAFAEKPEAGTPMSVIGEASSCGQGGLLRGIPLARAGRRTGAFAHRYGFRH FT SVITRSPSAG" FT CDS 106359..106658 FT /transl_table=11 FT /gene="PE19" FT /locus_tag="Mb1819" FT /product="PE FAMILY PROTEIN" FT /note="Mb1819, PE19, len: 99 aa. Equivalent to Rv1791, len: FT 99 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 99 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, but no glycine rich FT C-terminus, highly similar to Z93777|MTCI364.07 FT M.tuberculosis cosmid (99 aa) opt: 430 E(): 2.4e-21, (75.5% FT identity in 98 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ1" FT /protein_id="CAD94522.1" FT /translation="MSFVTTQPEALAAAAANLQGIGTTMNAQNAAAAAPTTGVVPAAAD FT EVSALTAAQFAAHAQMYQTVSAQAAAIHEMFVNTLVASSGSYAATEAANAAAAG" FT CDS 106802..107098 FT /transl_table=11 FT /gene="esxM" FT /locus_tag="Mb1820" FT /standard_name="TB11.0; QILSS" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1820, esxM, len: 98 aa. Equivalent to Rv1792, len: FT 98 aa, from Mycobacterium tuberculosis strain H37Rv, (98.0% FT identity in 98 aa overlap). esxM, conserved hypothetical FT protein, member of Mycobacterium tuberculosis QILSS FT familyof proteins, genes linked to those of ESAT-6 family. FT Has in-frame stop codon at 18074, no error could be found FT to account for this. Identical (apart from stop codon) to FT P96363|Rv1038c|MTCY10G2.11 PUTATIVE ESAT-6 LIKE PROTEIN 2 FT (98 aa), FASTA scores: opt: 389, E(): 5.8e-26, (100.0% FT identity in 58 aa overlap). Also identical to Rv1038c, FT Rv1197, and almost identical to Rv3620c and Rv2347c. FT Similar protein present in Mycobacterium leprae e.g. FT Q49946|MLCB1701.06C|AL049191 PUTATIVE ESAT-6 LIKE PROTEIN X FT (95 aa), FASTA scores: opt: 343, E(): 1.6e-17, (57.6% FT identity in 92 aa overlap)." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:P59805" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94523.1" FT /translation="MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGW FT SGQAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS" FT CDS 107149..107433 FT /transl_table=11 FT /gene="esxN" FT /locus_tag="Mb1821" FT /standard_name="ES6_5; Mtb9.9A" FT /product="PUTATIVE ESAT-6 LIKE PROTEIN 5" FT /note="Mb1821, esxN, len: 94 aa. Equivalent to Rv1793, len: FT 94 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 94 aa overlap). esxN, putative ESAT-6 FT like protein, conserved hypothetical protein, almost FT identical to several hypothetical mycobacterial proteins of FT the ESAT-6-like family including FT P95242|Rv2346c|MTCY98.15C|Z83860 PUTATIVE ESAT-6 LIKE FT PROTEIN 6 (94 aa), FASTA scores: opt: 610, E(): 0, (97.9 % FT identity in 94 aa overlap); Rv3619c, Rv1037c, and Rv1198, FT etc. Also present in Mycobacterium leprae." FT /db_xref="InterPro:IPR009416" FT /db_xref="UniProtKB/Swiss-Prot:P0A571" FT /protein_id="CAD94524.1" FT /translation="MTINYQFGDVDAHGAMIRAQAASLEAEHQAIVRDVLAAGDFWGGA FT GSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA" FT CDS 107521..108423 FT /transl_table=11 FT /gene="Mb1822" FT /locus_tag="Mb1822" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1822, -, len: 300 aa. Equivalent to Rv1794, len: FT 300 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 300 aa overlap). Conserved hypothetical FT protein, slight similarity to Mycobacterium tuberculosis FT O53694|Rv0289|MTV035.17, (295 aa), FASTA scores: opt: 172, FT E(): 0.00083, (25.7% identity in 261 aa overlap). FT Equivalent to Mycobacterium leprae hypothetical protein FT Q9Z5I1|MLCB596.31|AL035472 (300 aa), (88.0% identity in 300 FT aa overlap). Contains PS00211 ABC transporters family FT signature." FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:Q7TZJ0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94525.1" FT /translation="MDQQSTRTDITVNVDGFWMLQALLDIRHVAPELRCRPYVSTDSND FT WLNEHPGMAVMREQGIVVNDAVNEQVAARMKVLAAPDLEVVALLSRGKLLYGVIDDENQ FT PPGSRDIPDNEFRVVLARRGQHWVSAVRVGNDITVDDVTVSDSASIAALVMDGLESIHH FT ADPAAINAVNVPMEEMLEATKSWQESGFNVFSGGDLRRMGISAATVAALGQALSDPAAE FT VAVYARQYRDDAKGPSASVLSLKDGSGGRIALYQQARTAGSGEAWLAICPATPQLVQVG FT VKTVLDTLPYGEWKTHSRV" FT CDS 108695..110206 FT /transl_table=11 FT /gene="Mb1823" FT /locus_tag="Mb1823" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1823, -, len: 503 aa. Equivalent to Rv1795, len: FT 503 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 503 aa overlap). Conserved hypothetical FT membrane protein, has a hydrophilic stretch from ~1-130 FT then very hydrophobic. Similar to several other FT mycobacterial proteins, all linked to ESAT-6 family e.g. FT Rv3887c|MTY15F10.24|Z94121 (509 aa), FASTA scores: opt: FT 360, E(): 1.6e-15, (26.7% identity in 514 aa overlap); FT Rv3448, and Rv0290." FT /db_xref="InterPro:IPR006707" FT /db_xref="UniProtKB/TrEMBL:Q7TZI9" FT /protein_id="CAD94526.1" FT /translation="MTAVADAPQADIEGVASPQAVVVGVMAGEGVQIGVLLDANAPVSV FT MTDPLLKVVNSRLRELGEAPLEATGRGRWALCLVDGAPLRATQSLTEQDVYDGDRLWIR FT FIADTERRSQVIEHISTAVASDLSKRFARIDPIVAVQVGASMVATGVVLATGVLGWWRW FT HHNTWLTTIYTAVIGVLVLAVAMLLLMRAKTDADRRVADIMLMSAIMPVTVAAAAAPPG FT PVGSPQAVLGFGVLTVAAALALRFTGRRLGIYTAIVIIDALTMLAALARMVAATSAVTL FT LSSLLLICVVAYHAAPALSRRLAGIRLPVFPSATSRWVFEARPDLPTTVVVSGGSAPVL FT EGPSSVRDVLLQAERARSFLSGLLTGLGVMVVVCMTSLCDPHTGQRWLPLILAGFTSGF FT LLLRGRSYVDRWQSITLAGTAVIIAAAVCVRYALELSSPLAVSIVAAILVLLPAAGMAA FT AAHVPHTIYSPLFRKFVEWIEYLCLMPIFPLALWLMNVYAAIRYR" FT CDS 110184..111941 FT /transl_table=11 FT /gene="Mb1824" FT /locus_tag="Mb1824" FT /product="CONSERVED HYPOTHETICAL PRO-RICH PROTEASE" FT /note="Mb1824, -, len: 585 aa. Equivalent to Rv1796, len: FT 585 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 585 aa overlap). Conserved hypothetical FT Pro-rich protease. Member of family with four other FT Mycobacterium tuberculosis hypothetical proteases including FT Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa), FASTA scores: FT opt: 1173, E(): 0, (47.9% identity in 578 aa overlap); FT Rv0291, Rv3883c, and Rv3449. Genes all linked to those of FT ESAT-6 family. Has possible N-terminal signal peptide and FT hydrophobic anchor-like stretch at C-terminus. Contains two FT serine protease, subtilase family active site motifs: a FT aspartic acid active site motif (PS00136); and a histidine FT active site motif (PS00137)." FT /db_xref="GOA:Q7TZI8" FT /db_xref="HSSP:1MPT" FT /db_xref="InterPro:IPR000209" FT /db_xref="UniProtKB/TrEMBL:Q7TZI8" FT /protein_id="CAD94527.1" FT /translation="MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPTI FT DPGALPPDGPPGPLAPMKQNAYCTEVGVLPGTDFQLQPKYMEMLNLNEAWQFGRGDGVK FT VAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDAHGTLVASMIAAVPANGAVPLPSV FT PRRPVTIPTTETPPPPQTVTLSPVPPQTVTVIPAPPPEEGVPPGAPVPGPEPPPAPGPQ FT PPAVDRGGGTVTVPSYSGGRKIAPIDNPRNPHPSAPSPALGPPPDAFSGIAPGVEIISI FT RQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASVINISDVMCMSARNV FT IDQRALGAAVHYAAVDKDAVIVAAAGDGSKKDCKQNPIFDPLQPDDPRAWNAVTTVVTP FT SWFHDYVLTVGAVDANGQPLSKMSIAGPWVSISAPGTDVVGLSPRDDGLINAIDGPDNS FT LLVPAGTSFSAAIVSGVAALVRAKFPELSAYQIINRLIHTARPPARGVDNQVGYGVVDP FT VAALTWDVPKGPAEPPKQLSAPLVVPQPPAPRDMVPIWVAAGGLAGALLIGGAVFGTAT FT LMRRSRKQQ" FT CDS 111938..113158 FT /transl_table=11 FT /gene="Mb1825" FT /locus_tag="Mb1825" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1825, -, len: 406 aa. Equivalent to Rv1797, len: FT 406 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 406 aa overlap). Conserved hypothetical FT protein, some similarity to Mycobacterium tuberculosis FT O05462|Rv3882c|MTCY15F10.30|Z94121 (462 aa), FASTA scores: FT opt: 181, E(): 9.2e-05, (25.4% identity in 283 aa overlap). FT Has hydrophobic stretch near N-terminus." FT /db_xref="UniProtKB/TrEMBL:Q7TZI7" FT /protein_id="CAD94528.1" FT /translation="MKAQRSFGLALSWPRVTAVFLVDVLILAVASHCPDSWQADHHVAW FT WVGVGVAAVVTLLSVVSYHGITVISGLATWVRDWSADPGTTLGAGCTPAIDHQRRFGRD FT TVGVREYNGRLVSVIEVTCGESGPSGRHWHRKSPVPMLPVVAVADGLRQFDIHLDGIDI FT VSVLVRGGVDAAKASASLQEWEPQGWKSEERAGDRTVADRRRTWLVLRMNPQRNVAAVA FT CRDSLASTLVAATERLVQDLDGQSCAARPVTADELTEVDSAVLADLEPTWSRPGWRHLK FT HFNGYATSFWVTPSDITSETLDELCLPDSPEVGTTVVTVRLTTRVGSPALSAWVRYHSD FT TRLPKEVAAGLNRLTGRQLAAVRASLPAPTHRPLLVIPSRNLRDHDELVLPVGQELEHA FT TSSFVGQ" FT CDS 113155..114987 FT /transl_table=11 FT /gene="Mb1826" FT /locus_tag="Mb1826" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1826, -, len: 610 aa. Equivalent to Rv1798, len: FT 610 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 610 aa overlap). Conserved hypothetical FT protein, similar to several mycobacterial proteins e.g. FT O05460|MTCY15F10.28|Rv3884c|Z94121 from M. tuberculosis FT (619 aa), FASTA scores: opt: 669, E(): 0, (31.0% identity FT in 549 aa overlap); and O33089|MLCB628.18c|Y14967 from FT Mycobacterium leprae (573 aa), FASTA scores: opt: 723, E(): FT 0, (32.4% identity in 568 aa overlap). Also very similar to FT Rv0282. May belong to the CBXX/CFQX family as last ~320 aa FT domain very similar to several family members. Contains FT ATP/GTP-binding site motif A (P-loop; PS00017)." FT /db_xref="GOA:P63745" FT /db_xref="HSSP:1IN7" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P63745" FT /protein_id="CAD94529.1" FT /translation="MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTA FT TRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSDGLFL FT RLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRTKRW FT PDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIA FT LYTQGMCLRHVGREEEAVELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDP FT WDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTKVNLARA FT KMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMA FT DAEKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVF FT GAGYAKAMEKMLEVNQGLRRRFSTVIEFFSYTPQELIALTQLMGRENEDVITEEESQVL FT LPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHRSFRLDDEDLDAVLASD FT LTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK" FT CDS 115614..115805 FT /transl_table=11 FT /gene="lppT" FT /locus_tag="Mb1827" FT /product="PROBABLE LIPOPROTEIN LPPT" FT /note="Mb1827, lppT, len: 63 aa. Equivalent to Rv1799, len: FT 63 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 63 aa overlap). Probable lppT FT lipoprotein, has possible signal peptide and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="UniProtKB/TrEMBL:Q7TZI6" FT /protein_id="CAD94530.1" FT /translation="MSVKSKNGRLAARVLVALAALFAMIALTGSACLAEGPPLGRNPQG FT APAPVGGTVIVAPMHSGV" FT CDS 115908..117875 FT /transl_table=11 FT /gene="PPE28" FT /locus_tag="Mb1828" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1828, PPE28, len: 655 aa. Equivalent to Rv1800, FT len: 655 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 655 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, C-terminal very similar to parts of PE proteins FT e.g. Z92770|MTCI5.25|Rv0151c (588 aa), FASTA scores: opt: FT 1269, E(): 0, (41.5% identity in 591 aa overlap)." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/TrEMBL:Q7TZI5" FT /protein_id="CAD94531.1" FT /translation="MLPNFAVLPPEVNSARVFAGAGSAPMLAAAAAWDDLASELHCAAM FT SFGSVTSGLVVGWWQGSASAAMVDAAASYIGWLSTSAAHAEGAAGLARAAVSVFEEALA FT ATVHPAMVAANRAQVASLVASNLFGQNAPAIAALESLYEWMWAQDAAAMAGYYVGASAV FT ATQLASWLQRLQSIPGAASLDARLPSSAEAPMGVVRAVNSAIAANAAAAQTVGLVMGGS FT GTPIPSARYVELANALYMSGSVPGVIAQALVTPQGLYPVVVIKNLTFDSSVAQGAVILE FT SAIRQQIAAGNNVTVFGYSQSATISSLVMANLAASADPPSPDELSFTLIGNPNNPNGGV FT ATRFPGISFPSLGVTATGATPHNLYPTKIYTIEYDGVADFPRYPLNFVSTLNAIAGTYY FT VHSNYFILTPEQIDAAVPLTNTVGPTMTQYYIIRTENLPLLEPLRSVPIVGNPLANLVQ FT PNLKVIVNLGYGDPAYGYSTSPPNVATPFGLFPEVSPVVIADALAAGTQQGIGDFAYDV FT SHLELPLPADGSTMPSTAPGSGTPVPPLSIDSLIDDLQVANRNLANTISKVAATSYATV FT LPTADIANAALTIVPSYNIHLFLEGIQQALKGDPMGLVNAVGYPLAADVALFTAAGGLQ FT LLIIISAGRTIANDISAIVP" FT CDS 118456..119727 FT /transl_table=11 FT /gene="PPE29" FT /locus_tag="Mb1829" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1829, PPE29, len: 423 aa. Equivalent to Rv1801, FT len: 423 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 423 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, most similar to AL022021|MTV049.29|Rv1808 (409 FT aa), FASTA scores: opt: 1229, E(): 0, (55.2% identity in FT 422 aa overlap). TBparse score is 0.927." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZI4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94532.1" FT /translation="MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGY FT ASELSALTGAWSGPSSTSMASAAAPYVAWMSATAVHAELAGAQARLAIAAYEAAFAATV FT PPPVIAANRAQLMVLIATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATASRM FT TAFTEPPQTTNHGQLGAQSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALPTASQ FT SASATPQWVTDLGNLSTFLGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSAL FT LGKIGGKPITGALAPLAEFALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAA FT PEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAV FT GAAAAAVEDLATEANIFVIPAMDD" FT CDS 119839..121230 FT /transl_table=11 FT /gene="PPE30" FT /locus_tag="Mb1830" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1830, PPE30, len: 463 aa. Equivalent to Rv1802, FT len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 463 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, most similar to AL022021|MTV049.30|Rv1809 (468 FT aa), FASTA scores: opt: 1238, E(): 0, (51.0% identity in FT 471 aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:P0A693" FT /protein_id="CAD94533.1" FT /translation="MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATELQSTAADY FT GSVISVLTGVWSGQSSGTMAAAAAPYVAWMSATAALAREAAAQASAAAAAYEAAFAATV FT PPPVVAANRAELAVLAATNIFGQNTGAIAAAEARYAEMWAQDAAAMYGYAGSSSVATQV FT TPFAAPPPTTNAAGLATQGVAVAQAVGASAGNARSLVSEVLEFLATAGTNYNKTVASLM FT NAVTGVPYASSVYNSMLGLGFAESKMVLPANDTVISTIFGMVQFQKFFNPVTPFNPDLI FT PKSALGAGLGLRSAISSGLGSTAPAISAGASQAGSVGGMSVPPSWAAATPAIRTVAAVF FT SSTGLQAVPAAAISEGSLLSQMALASVAGGALGGAAARATGGFLGGGRVTAVKKSLKDS FT DSPDKLRRVVAHMMEKPESVQHWHTDEDGLDDLLAELKKKPGIHAVHMAGGNKAEIAPT FT ISESG" FT CDS complement(121378..123000) FT /transl_table=11 FT /gene="PE_PGRS32b" FT /locus_tag="Mb1831c" FT /product="PE-PGRS FAMILY PROTEIN [SECOND PART]" FT /note="Mb1831c, PE_PGRS32b, len: 540 aa. Equivalent to 3' FT end of Rv1803c, len: 639 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 540 aa FT overlap). Member of the Mycobacterium tuberculosis PE FT family, PGRS subfamily of gly-rich proteins. Most similar FT to Rv1768|MTCY28.34|Z95890 (618 aa), FASTA scores: opt: FT 1827, E( ): 0, (53.5% identity in 664 aa overlap). Contains FT two PS00583 pfkB family of carbohydrate kinases signatures FT 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, PE_PGRS32 exists as a single FT gene. In Mycobacterium bovis, a frameshift due to a single FT base transition (c-t) splits PE_PGRS32 into 2 parts, FT PE_PGRS32a and PE_PGRS32b, with PE_PGRS32a being FT truncated." FT /db_xref="UniProtKB/TrEMBL:Q7TZI3" FT /protein_id="CAD94534.1" FT /translation="MQIVGQTALDAINSPVQTLTGRPLIGNGANGVAGTGQNGGDGGWL FT YGNGGNGGSGGTGQNGGNGGSAGLWGSGGNGGQGGAGANGAAGQPGKAGGSGGNGGAGG FT WIYGHGGHGGAGGNGGNATAPGGASAGFDGGAGGNGGSGGRGGLLFGNGGNGSVGGMGG FT QGTNDTAGDSAGSGGLGGNGGNGAQGGWLIGNGGQGGDSGAGGGTDSTQTGVMNGASGG FT SAGIAGNGGDAGLVGNGGAGGNGGNGAAGSALGTTIFGGSGGVGGSGGDGGNGGWLFGS FT GASGGNGGQGGDAGTNGFAGFGGSAGGGGWVGAVNFGPISVQGFGLFGHGGDGGNGGDV FT GAGSLSIQFGASGGDGGQGGVLYGNGGNGGNAGSGGGTGFEGSAGQGGAAILIGNGGAG FT GNGATGGTGVGNIIQEAGGDGSDGGAGGSGGLLFGSGGAGGIGGAGGVGGSGNDGGNGG FT DGGQGGASGLGIGNGGPGGSGGTGGAGGTGGSAGTGGAGGDGGNAALLIGTGGDGGDGV FT PPAPGGQGGKGGLIGLPGQNGQP" FT CDS complement(123034..123297) FT /transl_table=11 FT /gene="PE_PGRS32a" FT /locus_tag="Mb1832c" FT /product="PE-PGRS FAMILY PROTEIN [FIRST PART]" FT /note="Mb1832c, PE_PGRS32a, len: 87 aa. Equivalent to 5' FT end of Rv1803c, len: 639 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 87 aa FT overlap). Member of the Mycobacterium tuberculosis PE FT family, PGRS subfamily of gly-rich proteins. Most similar FT to Rv1768|MTCY28.34|Z95890 (618 aa), FASTA scores: opt: FT 1827, E( ): 0, (53.5% identity in 664 aa overlap). Contains FT two PS00583 pfkB family of carbohydrate kinases signatures FT 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, PE_PGRS32 exists as a single FT gene. In Mycobacterium bovis, a frameshift due to a single FT base transition (c-t) splits PE_PGRS32 into 2 parts, FT PE_PGRS32a and PE_PGRS32b, with PE_PGRS32a being FT truncated." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZI2" FT /protein_id="CAD94535.1" FT /translation="MWTSQMIVAPAFVDAAAKDLATIGSAISRANAEALVPITALLPAG FT ADDVSAAIAALFATHGQAYQELSAHAVAFHEQFVQLMSAGAA" FT CDS complement(123478..123804) FT /transl_table=11 FT /gene="Mb1833c" FT /locus_tag="Mb1833c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1833c, -, len: 108 aa. Equivalent to Rv1804c, len: FT 108 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 108 aa overlap). Conserved hypothetical FT protein, similar to several hypothetical Mycobacterium FT tuberculosis proteins that may be exported (hydrophobic FT stretch at N-terminus) e.g. FT O07222|Rv1810|MTCY16F9.04C|Z96073 (118 aa), FASTA scores: FT opt: 361, E(): 2.3e-19, (53.5% identity in 101 aa overlap); FT Rv0622, Rv1690, and Rv3067, etc." FT /db_xref="InterPro:IPR007969" FT /db_xref="UniProtKB/TrEMBL:Q7TZI1" FT /protein_id="CAD94536.1" FT /translation="MRVVSTLLSIPLMIGLAVPAHAGPSGDDAVFLASLERAGITYSHP FT DQAIASGKAVCALVESGESGLQVVNELRTRNPGFSMDGCCKFAAISAHVYCPHQITKTS FT VSAK" FT CDS complement(124142..124489) FT /transl_table=11 FT /gene="Mb1834c" FT /locus_tag="Mb1834c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1834c, -, len: 115 aa. Equivalent to Rv1805c, len: FT 115 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 115 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZI0" FT /protein_id="CAD94537.1" FT /translation="MTASVVATSRERHSHKAAKQRACEITDFEPEGRFRVRKRRRGRIG FT TKRSSISDTDYRRDSFRSHLLTAGAHGDADAQHKGMTAQQTTELGTPLVRALAPHGVSG FT RSSRKPLGLNP" FT CDS 124527..124826 FT /transl_table=11 FT /gene="PE20" FT /locus_tag="Mb1835" FT /product="PE FAMILY PROTEIN" FT /note="Mb1835, PE20, len: 99 aa. Equivalent to Rv1806, len: FT 99 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 99 aa overlap). Member of the FT Mycobacterium tuberculosis PE family of gly-, ala-rich FT proteins, most similar to Rv1788|MTV049.10|AL022021 (99 FT aa), FASTA scores: opt: 334, E(): 4.7 e-15, (59.8% identity FT in 97 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZH9" FT /protein_id="CAD94538.1" FT /translation="MAFVLVCPDALAIAAGQLRHVGSVIAARNAVAAPATAELAPAAAD FT EVSALTATQFNFHAAMYQAVGAQAIAMNEAFVAMLGASADSYAATEAANIIAVS" FT CDS 124853..126052 FT /transl_table=11 FT /transl_except=(pos:124853..124855,aa:Met) FT /gene="PPE31" FT /locus_tag="Mb1836" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1836, PPE31, len: 399 aa. Equivalent to Rv1807, FT len: 399 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 399 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, most similar to Rv1789|MTV049.11|AL022021 (393 FT aa), FASTA scores: opt: 1169, E(): 0, (49.5% identity in FT 399 aa overlap). Start changed since original submission." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZH8" FT /protein_id="CAD94539.1" FT /translation="MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAELRASALSY FT SSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAGAQAEAAAAAYEAAFAAT FT VPPPVIEANRAQLMALIATNVLGQNAPAIAATEAQYAEMWSQDAMAMYGYAGASAAATQ FT LTPFTEPVQTTNASGLAAQSAAIAHATGASAGAQQTTLSQLIAAIPSVLQGLSSSTAAT FT SASGPSGLLGILGSGSSWLDKLWALLDPNSNFWNTIASSGLFLPSNTIAPFLGLLGGVA FT AADAAGDVLGEATSGGLGGALVAPLGSAGGLGGTVAAGLGNAATVGTLSVPPSWTAAAP FT LASPLGSALGGTPMVAPPPAVAAGMPGMPFGTMGGQGFGRAVPQYGFRPNFVARPPAAG FT " FT CDS 126376..127605 FT /transl_table=11 FT /gene="PPE32" FT /locus_tag="Mb1837" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1837, PPE32, len: 409 aa. Equivalent to Rv1808, FT len: 409 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.000% identity in 409 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, most similar to Rv1800|MTV049.22|AL022021 (655 FT aa), FASTA scores: opt: 1225, E(): 0, (55.1% identity in FT 423 aa overlap). Contains PS00343 Gram-positive cocci FT surface proteins 'anchoring' hexapeptide. TBparse score is FT 0.919." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZH7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94540.1" FT /translation="MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASY FT GSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAAT FT VPPPVIEANRALLMSLVATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQ FT LAPFSEPPQTTNPSATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATA FT TSASAGWDTVLQSITTILANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLG FT PKAAAGALSPLAPLRGGYIADITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVA FT SVLPGTGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRSGAGAARVAGGSVTEDVAS FT TTTIIVIPAD" FT CDS 127737..128300 FT /transl_table=11 FT /gene="PPE33a" FT /locus_tag="Mb1838" FT /product="PPE FAMILY PROTEIN [FIRST PART]" FT /note="Mb1838, PPE33a, len: 187 aa. Equivalent to 5' end of FT Rv1809, len: 468 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 187 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, most similar to RV1802AL022021|MTV049.23 (463 FT aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in FT 471 aa overlap). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base transition (c-t) splits PPE33 into 2 parts, FT PPE33a and PPE33b, with PPE33a being truncated." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7TZH6" FT /protein_id="CAD94541.1" FT /translation="MDFGLQPPEITSGEMYLGPGAGPMLAAAVAWDGLAAELQSMAASY FT ASIVEGMASESWLGPSSAGMAAAAAPYVTWMSGTSAQAKAAADQARAAVVAYETAFAAV FT VPPPQIAANRSQLISLVATNIFGQNTAAIAATEAEYGEMWAQDTMAMFGYASSSATASR FT LTPFTAPPQTTNPSGLAGQAAATG" FT CDS 128301..129149 FT /pseudo FT /transl_table=11 FT /gene="PPE33b" FT /locus_tag="Mb1839" FT /product="PPE FAMILY PROTEIN [SECOND PART]" FT /note="Mb1839, PPE33b, len: 282 aa. Equivalent to 3' end of FT Rv1809, len: 468 aa, from Mycobacterium tuberculosis strain FT H37Rv, (). Member of the Mycobacterium tuberculosis PPE FT family of glycine-rich proteins, most similar to FT RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, FT E(): 0, (51.2% identity in 471 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, PPE33 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT transition (c-t), splits PPE33 into 2 parts, PPE33a and FT PPE33b, with PPE33a being truncated." FT CDS 129388..129744 FT /transl_table=11 FT /gene="Mb1840" FT /locus_tag="Mb1840" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1840, -, len: 118 aa. Equivalent to Rv1810, len: FT 118 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 118 aa overlap). Conserved hypothetical FT protein, similar to several hypothetical Mycobacterium FT tuberculosis proteins that may be exported (possible FT N-terminal signal sequence) e.g. FT O53953|Rv1804c|MTV049.26c|AL022021 (108 aa), FASTA scores: FT opt: 361, E(): 9.6e-17, (53.5% identity in 101 aa overlap); FT Rv0622, and Rv1690, etc." FT /db_xref="InterPro:IPR007969" FT /db_xref="UniProtKB/TrEMBL:Q7TZH5" FT /protein_id="CAD94543.1" FT /translation="MQLQRTMGQCRPMRMLVALLLSAATMIGLAAPGKADPTGDDAAFL FT AALDQAGITYADPGHAITAAKAMCGLCANGVTGLQLVADLRDYNPGLTMDSAAKFAAIA FT SGAYCPEHLEHHPS" FT CDS 129898..130602 FT /transl_table=11 FT /gene="mgtC" FT /locus_tag="Mb1841" FT /product="POSSIBLE Mg2+ TRANSPORT P-TYPE ATPASE C MGTC" FT /EC_number="3.6.3.1" FT /note="Mb1841, -, len: 234 aa. Equivalent to Rv1811, len: FT 234 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 234 aa overlap). Possible mgtC, FT magnesium (Mg2+) transport P-type ATPase C (transmembrane FT protein) (EC 3.6.3.1), highly similar to many e.g. FT NP_442124.1|NC_000911 Mg2+ transport ATPase from FT Synechocystis sp. strain PCC 6803 (234 aa); FT NP_251248.1|NC_002516 probable transport protein from FT Pseudomonas aeruginosa (230 aa); P22037|ATMC_SALTY|STM3764 FT magnesium transport ATPase protein C from Salmonella FT typhimurium (231 aa), FASTA scores: opt: 545, E(): 4.1e-30, FT (42.3% identity in 220 aa overlap); N-terminus of FT NP_213315.1|NC_000918 Mg(2+) transport ATPase from Aquifex FT aeolicus (225 aa); etc. BELONGS TO THE MGTC / SAPB FAMILY" FT /db_xref="GOA:Q7TZH4" FT /db_xref="InterPro:IPR003416" FT /db_xref="UniProtKB/TrEMBL:Q7TZH4" FT /protein_id="CAD94544.1" FT /translation="MQTLTVADFALRLAVGVGCGAIIGLERQWRARMAGLRTNALVATG FT ATLFVLYAVATEDSSPTRVASYVVSGIGFLGGGVILREGFNVRGLNTAATLWCSAAVGV FT LAASGHLVFTLIGTGTIVAVHLLGRPLGRLVDRDNAVEDEGLQPYQVRVICRPKAETYV FT RAHIVQRTSSNDITLRGIRTGPAGDDNITLTAHLLMVGHTPAKLERLVAELSLQPGVYA FT VHWYAGEHAQAE" FT CDS complement(130612..131814) FT /transl_table=11 FT /gene="Mb1842c" FT /locus_tag="Mb1842c" FT /product="PROBABLE DEHYDROGENASE" FT /EC_number="1.-.-.-" FT /note="Mb1842c, -, len: 400 aa. Equivalent to Rv1812c, len: FT 400 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 400 aa overlap). Probable dehydrogenase FT (EC 1.-.-.-), similar to other dehydrogenases/oxidases e.g. FT AE001947|AE001947_10 NADH dehydrogenase II of Deinococcus FT radiodurans (379 aa), FASTA scores: opt: 404, E(): 3.4e-18, FT (26.4% identity in 363 aa overlap) and DHNA_HAEIN|P44856 FT nadh dehydrogenase (EC 1.6.99.3) (444 aa), FASTA scores: FT opt: 200, E(): 8.5e-06, (23.3% identity in 258 aa overlap). FT Also similar to Mycobacterium tuberculosis hypothetical FT dehydrogenases Rv0392c, and Rv1854c|MTCY359.19 ndh probable FT NADH dehydrogenase (31.5% identity in 321 aa overlap)." FT /db_xref="GOA:Q7TZH3" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:Q7TZH3" FT /protein_id="CAD94545.1" FT /translation="MTRVVVIGSGFAGLWAALGAARRLDELAVPAGTVDVMVVSNKPFH FT DIRVRNYEADLSACRIPLGDVLGPAGVAHVTAEVTAIDADGRRVTTSTGASYSYDRLVL FT ASGSHVVKPALPGLAEFGFDVDTYDGAVRLQQHLQGLAGGPLTSAAATVVVVGAGLTGI FT ETACELPGRLHALFARGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQALLDNGVETRTG FT VSVAAVSPGGVTLSSGERLAAATVVWCAGMRASRLTEQLPVARDRLGRLQVDDYLRVIG FT VPAMFAAGDVAAARMDDEHLSVMSCQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTV FT LDLGSAGAVYTEGWERKVVSQGAPAKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPR FT P" FT CDS complement(132136..132567) FT /transl_table=11 FT /gene="Mb1843c" FT /locus_tag="Mb1843c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1843c, -, len: 143 aa. Equivalent to Rv1813c, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 143 aa overlap). Conserved hypothetical FT protein. Possibly a exported protein with potential FT N-terminal signal sequence. Similar to FT Q11050|Rv1269c|MTCY50.13 hypothetical protein from FT Mycobacterium tuberculosis (124 aa), (42.7% identity in 143 FT aa overlap)." FT /db_xref="GOA:P64890" FT /db_xref="UniProtKB/Swiss-Prot:P64890" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94546.1" FT /translation="MITNLRRRTAMAAAGLGAALGLGILLVPTVDAHLANGSMSEVMMS FT EIAGLPIPPIIHYGAIAYAPSGASGKAWHQRTPARAEQVALEKCGDKTCKVVSRFTRCG FT AVAYNGSKYQGGTGLTRRAAEDDAVNRLEGGRIVNWACN" FT CDS 132976..133878 FT /transl_table=11 FT /gene="erg3" FT /locus_tag="Mb1844" FT /product="MEMBRANE-BOUND C-5 STEROL DESATURASE ERG3 FT (STEROL-C5-DESATURASE)" FT /EC_number="1.3.-.-" FT /note="Mb1844, erg3, len: 300 aa. Equivalent to Rv1814, FT len: 300 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 300 aa overlap). erg3, transmembrane FT C-5 sterol desaturase (EC 1.3.-.-) (see *), weak similarity FT to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase FT (365 aa), FASTA scores: opt: 154, E(): 0.0011, (22.9% FT identity in 288 aa overlap). BELONGS TO THE STEROL FT DESATURASE FAMILY. [* note work of Jackson, C.J., Lamb, FT D.C., Kelly, D.E., Kelly, S.L., Characterization of a FT sterol delta 5,6-desaturase homolog in Mycobacterium bovis FT (BCG). Submitted (JUN-2000) to the EMBL/GenBank/DDBJ FT databases]." FT /db_xref="GOA:P68434" FT /db_xref="InterPro:IPR006694" FT /db_xref="UniProtKB/Swiss-Prot:P68434" FT /protein_id="CAD94547.1" FT /translation="MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYL FT TRDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLL FT YYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPPWMV FT FCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWD FT RLFGSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPG FT WEPRTIDKSNAAASLVTSR" FT CDS 133983..134648 FT /transl_table=11 FT /gene="Mb1845" FT /locus_tag="Mb1845" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1845, -, len: 221 aa. Equivalent to Rv1815, len: FT 221 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 221 aa overlap). Conserved hypothetical FT protein, similar to G473456 hypothetical protein from FT Mycobacterium fortuitum (255 aa), FASTA scores: opt: 182, FT E(): 3.2e-05, (29.6% identity in 230 aa overlap)." FT /db_xref="GOA:P59981" FT /db_xref="UniProtKB/Swiss-Prot:P59981" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94548.1" FT /translation="MVRLVPRAFAATVALLAAGFSPATASADPVLVFPGMEIRQDNHVC FT TLGYVDPALKIAFTAGHCRGGGAVTSRDYKVIGHLRAFRDNTPSGSTVATHELIADYEA FT IVLADDVTASNILPSGRALESRPGVVLHPGQAVCHFGVSTGETCGTVESVNNGWFTMSH FT GVLSEKGDSGGPVYLAPDGGPAQIVGIFNSVWGGFPAAVSWRSTSEQVHADLGVTPLA" FT CDS 134711..135415 FT /transl_table=11 FT /gene="Mb1846" FT /locus_tag="Mb1846" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1846, -, len: 234 aa. Equivalent to Rv1816, len: FT 234 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 234 aa overlap). Possible FT transcriptional regulatory protein. MEME analysis suggests FT similarity to putative Mycobacterium tuberculosis FT transcriptional regulators, Rv0653c, Rv0681. Contains FT helix-turn-helix motif at aa 38-59 (+4.30 SD)." FT /db_xref="GOA:P67439" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:P67439" FT /protein_id="CAD94549.1" FT /translation="MCQTCRVGKRRDAREQIEAKIVELGRRQLLDHGAAGLSLRAIARN FT LGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRARDDTVADSWSDDVIAIARAVRG FT WAVTNPARWALLYGSPVPGYHAPPDRTAGVATRVVGAFFDAIAAGIATGDIRLTDDVAP FT QPMSSDFEKIRQEFGFPGDDRVVTKCFLLWAGVVGAISLEVFGQYGADMLTDPGVVFDA FT QTRLLVAVLAEH" FT CDS 135896..135976 FT /transl_table=11 FT /gene="Mb1847" FT /locus_tag="Mb1847" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1847, -, len: 26 aa. Equivalent to Rv1816A, len: FT 26 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 26 aa overlap). Conserved hypothetical FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZH2" FT /protein_id="CAD94550.1" FT /translation="MSRAGDDAVGVPPACGGRSDDEERRQ" FT CDS 136050..137513 FT /transl_table=11 FT /gene="Mb1848" FT /locus_tag="Mb1848" FT /product="POSSIBLE FLAVOPROTEIN" FT /note="Mb1848, -, len: 487 aa. Equivalent to Rv1817, len: FT 487 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 487 aa overlap). Possible flavoprotein, FT similar to G746486 flavoprotein subunit of fumarate FT reductase fad domain homologue (474 aa), FASTA scores: opt: FT 223, E(): 5.7e-07, (24.1% identity in 489 aa overlap); and FT AJ236923|SFR236923_3 soluble fumarate reductase of FT Shewanella frigidimarina ifcA (588 aa), FASTA scores: opt: FT 310, E(): 2.5e-11, (27.3% identity in 484 aa overlap)." FT /db_xref="GOA:Q7TZH1" FT /db_xref="HSSP:1D4D" FT /db_xref="InterPro:IPR003953" FT /db_xref="UniProtKB/TrEMBL:Q7TZH1" FT /protein_id="CAD94551.1" FT /translation="MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGAR FT VLVLERAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYLVAVSREPDHDKIR FT AYCDGSVEHFNWLEGLGFQFERSYFPGKAVIQPNTEGLMFTGNEKVWPFLELAVPAPRG FT HKVPVPGDTGGAAMVIDLLLKRAASLGIQIRYETGATELIVDGTGKVTGVMWKRFSETG FT AIKAKSVIIAAGGFVMNPDMVAKYTPKLAEKPFVLGNTYDDGLGIRLGVSAGGATQHMD FT QMFITAPPYPPSILLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIVDEAHLE FT HPKMPLVPLIDGWETVVEMEAALGIPPGNLAATLDRYNAYAARGADPDFHKQPEFLAAQ FT DNGPWGAFDMSLGKAMYAGFTLGGLATSVDGQVLRDDGAVVAGLYAVGACASNIAQDGK FT GYASGTQLGEGSFFGRRAGAHAAARAQGM" FT CDS complement(137633..139138) FT /transl_table=11 FT /gene="PE_PGRS33" FT /locus_tag="Mb1849c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1849c, PE_PGRS33, len: 501 aa. Equivalent to FT Rv1818c, len: 498 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.2% identity in 501 aa overlap). Member of FT the Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins (see first citation), similar to many. FT Contains 2 x PS00583 pfkB family of carbohydrate kinases FT signature 1. Supposed localised to the cell surface. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 FT bp insertion (*-gccgccggc), leads to a longer product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (501 aa versus 498 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZH0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94552.1" FT /translation="MSFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAAD FT EVSAAMAALFSGHAQAYQALSAQAALFHEQFVRALTAGAGSYAAAEAASAAPLEGVLDV FT INAPALALLGRPLIGNGANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAAGLF FT GNGGAGGAGGNVASGTAGFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGAGGNG FT GLLFGAGGAGSVGGLAADAGDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGAGGNGG FT LLFGAGGVGGVGGDGVAFLGTAPGGPGGAGGAGGLFGVGGAGGAGGIGLVGNGGAGGSG FT GSALLWGDGGAGGAGGVGSTTGGAGGAGGNAGLLVGAGGAGGAGALGGGATGVGGAGGN FT GGTAGLLFGAGGAGGAGGFGFGGAGGAGGLGGKAGLIGDGGDGGAGGNGTGAKGGDGGA FT GGGAILVGNGGNGGNAGSGTPNGSAGTGGAGGLLGKNGMNGLP" FT CDS complement(139273..141192) FT /transl_table=11 FT /gene="Mb1850c" FT /locus_tag="Mb1850c" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /note="Mb1850c, -, len: 639 aa. Equivalent to Rv1819c, len: FT 639 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 639 aa overlap). Probable FT drugs-transport transmembrane ATP-binding protein ABC FT transporter (see citation below), equivalent to FT AL008609|MLCB1788.47 hypothetical ABC transporter from FT Mycobacterium leprae (638 aa), (74.9% identity in 634 aa FT overlap). Also similar to other transmembrane ATP-binding FT proteins e.g. Q57335|Y036_HAEIN hypothetical ABC FT transporter ATP-binding protein from Haemophilus influenzae FT (592 aa), FASTA scores: opt: 1235, E(): 2.8e-61, (40.8% FT identity in 623 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), and PS00211 ABC FT transporters family signature. BELONGS TO THE ATP-BINDING FT TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7TZG9" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TZG9" FT /protein_id="CAD94553.1" FT /translation="MGPKLFKPSIDWSRAFPDSVYWVGKAWTISAICVLAILVLLRYLT FT PWGRQFWRITRAYFVGPNSVRVWLMLGVLLLSVVLAVRLNVLFSYQGNDMYTALQKAFE FT GIASGDGTVKRSGARGFWMSIGVFSVMAVLHVTRVMADIYLTQRFIIAWRVWLTHHLTQ FT DWLDGRAYYRDLFIDETIDNPDQRIQQDVDIFTAGAGGTPNAPSNGTASTLLFGAVQSI FT ISVISFTAILWNLSGTLNIFGVSIPRAMFWTVLVYVFVATVISFIIGRPLIWLSFRNEK FT LNAAFRYALVRLRDAAEAVGFYRGERVEGTQLQRRFTPVIDNYRRYVRRSIAFNGWNLS FT VSQTIVPLPWVIQAPRLFAGQIDFGDVGQTATSFGNIHDSLSFFRNNYDAFASFRAAII FT RLHGLVDANEKGRALPAVLTRPSDDESVELNDIEVRTPAGDRLIDPLDVRLDRGGSLVI FT TGRSGAGKTTLLRSLAELWPYASGTLHRPGGENETMFLSQLPYVPLGTLRDVVCYPNSA FT AAIPDATLRDTLTKVALAPLCDRLDEERDWAKVLSPGEQQRVAFARILLTKPKAVFLDE FT STSALDTGLEFALYQLLRSELPDCIVVSVSHRPALERLHENQLELLGGGQWRLAPVEAA FT PAEV" FT CDS 141263..142906 FT /transl_table=11 FT /gene="ilvG" FT /locus_tag="Mb1851" FT /product="Probable Acetolactate synthase ilvG FT (Acetohydroxy-acid synthase)(ALS)" FT /EC_number="2.2.1.6" FT /note="Mb1851, ilvG, len: 547 aa. Equivalent to Rv1820, FT len: 547 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 547 aa overlap). Probable ilvG, FT acetolactate synthase (EC 4.1.3.18). Equivalent to FT AL008609|MLCB1788.46c ilvG from Mycobacterium leprae (548 FT aa) (86.1% identity in 548 aa overlap). Similar to FT ILVB_KLEPN|P27696 (559 aa), FASTA scores: opt: 660, E(): FT 2.9e-34, (29.1% identity in 549 aa overlap). Also similar FT to other Mycobacterium tuberculosis Ilv proteins e.g. FT Rv3003c (ilvB), etc. Contains PS00187 Thiamine FT pyrophosphate enzymes signature." FT /db_xref="GOA:P66947" FT /db_xref="InterPro:IPR012000" FT /db_xref="UniProtKB/Swiss-Prot:P66947" FT /protein_id="CAD94554.1" FT /translation="MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCR FT EEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVV FT LGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVA FT FVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWW FT GHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDF FT RLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEE FT LATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDS FT YLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVA FT VVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPA FT LERAFASGLPAVVNVLTDPSVAYPRRSNLA" FT CDS 142921..145347 FT /transl_table=11 FT /gene="secA2" FT /locus_tag="Mb1852" FT /product="POSSIBLE PREPROTEIN TRANSLOCASE SECA2" FT /note="Mb1852, secA2, len: 808 aa. Equivalent to Rv1821, FT len: 808 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 808 aa overlap). Possible secA2, FT preprotein translocase, component of secretion apparatus, FT similar to several preprotein translocases e.g. FT P28366|SECA_BACSU preprotein translocase secA subunit from FT Bacillus subtilis (841 aa), FASTA scores: opt: 1424, E(): FT 0, (35.9% identity in 786 aa overlap). Equivalent to FT AL008609|MLCB1788.45 Preprotein translocase SecA 2 from FT Mycobacterium leprae (778 aa) (87.1% identity in 780 aa FT overlap). Also similar to Rv3240c|MTCY20B11.15c secA FT preprotein translocase from Mycobacterium tuberculosis (949 FT aa). COULD BE PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION FT APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, FT SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732." FT /db_xref="GOA:P66786" FT /db_xref="HSSP:1NKT" FT /db_xref="InterPro:IPR011116" FT /db_xref="UniProtKB/Swiss-Prot:P66786" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94555.1" FT /translation="MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSR FT FWRLLGASTEKNRSRSLADVTASAEYDKEAADLSDEKLRKAAGLLNLDDLAESADIPQF FT LAIAREAAERRTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHV FT HVVTINDYLARRDAEWMGPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFD FT VLRDQLVTDVNDLVSPNPDVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAE FT LVGDKDADEYFATDSDNRNVHLTEHGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAH FT VLLQRDVHYIVRDDAVHLINASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTIT FT VQALINRYATVCGMTGTALAAGEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKN FT DGIVEHITEVHQRGQPVLVGTRDVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEA FT GKYGAVTVSTQMAGRGTDIRLGGSDEADHDRVAELGGLHVVGTGRHHTERLDNQLRGRA FT GRQGDPGSSVFFSSWEDDVVAANLDHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRL FT LDVHANTWRYNQLIAQQRAIIVERRNTLLRTVTAREELAELAPKRYEELSDKVSEERLE FT TICRQIMLYHLDRGWADHLAYLADIRESIHLRALGRQNPLDEFHRMAVDAFASLAADAI FT EAAQQTFETANVLDHEPGLDLSKLARPTSTWTYMVNDNPLSDDTLSALSLPGVFR" FT CDS 145544..146173 FT /transl_table=11 FT /gene="pgsA2" FT /locus_tag="Mb1853" FT /product="PROBABLE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE FT 3-PHOSPHATIDYLTRANSFERASE PGSA2 (PGP SYNTHASE) FT (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) FT (3-PHOSPHATIDYL-1'-GLYCEROL-3'PHOSPHATE SYNTHASE)" FT /EC_number="2.7.8.5" FT /note="Mb1853, pgsA2, len: 209 aa. Equivalent to Rv1822, FT len: 209 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 209 aa overlap). Probable pgsA2, FT CDP-diacylglycerol--glycerol-3-phosphate FT 3-phosphatidyl-transferase (EC 2.7.8.5) (see citation FT below), integral membrane protein, equivalent to FT AL008609|MLCB1788_17 phosphatidyltransferase from FT Mycobacterium leprae (206 aa), FASTA score: (76.6% identity FT in 205 aa overlap). Also highly similar or similar to FT others e.g. CAB88885.1|AL353861 putative FT CDP-diacylglycerol--glycerol-3-phosphate FT 3-phosphatidyl-transferase from Streptomyces coelicolor FT (215 aa); AAC44003.1|U29587 phosphatidylglycerol phosphate FT synthase from Rhodobacter sphaeroides (227 aa); FT NP_405431.1|NC_003143 FT CDP-diacylglycerol--glycerol-3-phosphate FT 3-phosphatidyltransferase from Yersinia pestis (182 aa); FT P06978|PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate FT 3-phosphatidyltransferase from Escherichia coli (181 aa), FT FASTA scores: opt: 252, E(): 2.8e-09, (29.7% identity in FT 175 aa overlap); etc. Also similar to FT Rv2746c|PGSA3|MTV002.11c FT CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE FT 3-PHOSPHATIDYLTRANSFERASE (PGP SYNTHASE) from Mycobacterium FT tuberculosis (209 aa). Contains PS00379 CDP-alcohol FT phosphatidyltransferases signature; and PS00075 FT Dihydrofolate reductase signature. BELONGS TO THE FT CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY." FT /db_xref="GOA:P63754" FT /db_xref="InterPro:IPR004570" FT /db_xref="UniProtKB/Swiss-Prot:P63754" FT /protein_id="CAD94556.1" FT /translation="MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAIL FT VFSGVSDWADGKIARLLNQSSRLGALLDPAVDRLYMVTVPIVFGLSGIVPWWFVLTLLT FT RDALLAGTLPLLWSRGLSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLACGWA FT FLIWGMYAYLWAFVLYAVQMTMVVRQMPKLKGRAHRPAAQNAGERG" FT CDS 146166..147089 FT /transl_table=11 FT /gene="Mb1854" FT /locus_tag="Mb1854" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1854, -, len: 307 aa. Equivalent to Rv1823, len: FT 307 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 307 aa overlap). Conserved hypothetical FT protein, similar to P71582|MTCY10H4.12|RV0012 hypothetical FT protein CY10H4.12 from Mycobacterium tuberculosis (262 aa), FT FASTA scores: opt: 304, E(): 1.5e-12, (30.1% identity in FT 246 aa overlap)." FT /db_xref="GOA:P64892" FT /db_xref="InterPro:IPR010273" FT /db_xref="UniProtKB/Swiss-Prot:P64892" FT /protein_id="CAD94557.1" FT /translation="MAESDRLLGGYDPNAGYSAHAGAQPQRIPVPSLLRALLSEHLDAG FT YAAVAAERERAAAPRCWQARAVSWMWQALAATLVAAVFAAAVAQARSVAPGVRAAQQLL FT VASVRSTQAAATTLAQRRSTLSAKVDDVRRIVLADDAEGQRLLARLDVLSLAAASAPVV FT GPGLTVTVTDPGASPNLSDVSKQRVSGSQQIILDRDLQLVVNSLWESGAEAISIDGVRI FT GPNVTIRQAGGAILVDNNPTSSPYTILAVGPPHAMQDVFDRSAGLYRLRLLETSYGVGV FT SVNVGDGLALPAGATRDVKFAKQIGP" FT CDS 147118..147483 FT /transl_table=11 FT /gene="Mb1855" FT /locus_tag="Mb1855" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1855, -, len: 121 aa. Equivalent to Rv1824, len: FT 121 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 121 aa overlap). Conserved hypothetical FT membrane protein similar to P28265|SBP_BACSU sbp protein FT from Bacillus subtilis (121 aa), FASTA scores: opt: 261, FT E(): 1.9e-12, (38.9% identity in 113 aa overlap)." FT /db_xref="GOA:P64894" FT /db_xref="InterPro:IPR009709" FT /db_xref="UniProtKB/Swiss-Prot:P64894" FT /protein_id="CAD94558.1" FT /translation="MGSDTAWSPARMIGIAALAVGIVLGLVFHPGVPEVIQPYLPIAVV FT AALDAVFGGLRAYLERIFDPKVFVVSFVFNVLVAALIVYVGDQLGVGTQLSTAIIVVLG FT IRIFGNTAALRRRLFGA" FT CDS 147500..148378 FT /transl_table=11 FT /gene="Mb1856" FT /locus_tag="Mb1856" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1856, -, len: 292 aa. Equivalent to Rv1825, len: FT 292 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 292 aa overlap). Conserved hypothetical FT protein, weak similarity to Mycobacterium tuberculosis FT hypothetical proteins Q50610|MTCY1A11.20C|Rv1823|Z78020 FT (307 aa), FASTA scores: opt: 182, E(): 0.00044, (29.9% FT identity in 204 aa overlap); and Rv0012. Has a hydrophobic FT stretch, TMhelix from aa 67 to 85" FT /db_xref="GOA:P64896" FT /db_xref="InterPro:IPR010273" FT /db_xref="UniProtKB/Swiss-Prot:P64896" FT /protein_id="CAD94559.1" FT /translation="MSENRPEPVAAETSAATTARHSQADAGAHDAVRRGRHELPADHPR FT SKVGPLRRTRLTEILRGGRSRLVFGTLAILLCLVLGVAIVTQVRQTDSGDSLETARPAD FT LLVLLDSLRQREATLNAEVIDLQNTLNALQASGNTDQAALESAQARLAALSILVGAVGA FT TGPGVMITIDDPGPGVAPEVMIDVINELRAAGAEAIQINDAHRSVRVGVDTWVVGVPGS FT LTVDTKVLSPPYSILAIGDPPTLAAAMNIPGGAQDGVKRVGGRMVVQQADRVDVTALRQ FT PKQHQYAQPVK" FT CDS 148416..148820 FT /transl_table=11 FT /gene="gcvH" FT /locus_tag="Mb1857" FT /product="PROBABLE GLYCINE CLEAVAGE SYSTEM H PROTEIN GCVH" FT /note="Mb1857, gcvH, len: 134 aa. Equivalent to Rv1826, FT len: 134 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 134 aa overlap). Probable gcvH, glycine FT cleavage system H protein, highly similar to FT GCSH_ECOLI|P23884 glycine cleavage system H protein from FT Escherichia coli (129 aa), FASTA scores: opt: 428, E(): FT 2.2e-22, (47.8% identity in 134 aa overlap). Equivalent to FT MLCB1788.37c gcvH from Mycobacterium leprae (78.4% identity FT in 134 aa overlap). Contains PS00189 2-oxo acid FT dehydrogenases acyltransferase component lipoyl binding FT site. BELONGS TO THE GCVH FAMILY." FT /db_xref="GOA:Q7TZG8" FT /db_xref="HSSP:1HTP" FT /db_xref="InterPro:IPR017453" FT /db_xref="UniProtKB/Swiss-Prot:Q7TZG8" FT /protein_id="CAD94560.1" FT /translation="MSDIPSDLHYTAEHEWIRRSGDDTVRVGITDYAQSALGDVVFVQL FT PVIGTAVTAGETFGEVESTKSVSDLYAPISGKVSAVNSDLDGTPQLVNSDPYGAGWLLD FT IQVDSSDVAALESALTTLLDAEAYRGTLTE" FT CDS 149060..149548 FT /transl_table=11 FT /gene="cfp17" FT /locus_tag="Mb1858" FT /product="CONSERVED HYPOTHETICAL PROTEIN CFP17" FT /note="Mb1858, cfp17, len: 162 aa. Equivalent to Rv1827, FT len: 162 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 162 aa overlap). cfp17, conserved FT hypothetical protein (see citation below), equivalent to FT O32919|MLCB1788.36c hypothetical protein from Mycobacterium FT leprae (162 aa), FASTA scores: opt: 888, E(): 0, (87.0% FT identity in 161 aa overlap)." FT /db_xref="InterPro:IPR000253" FT /db_xref="PDB:2KKL" FT /db_xref="UniProtKB/Swiss-Prot:P64898" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94561.1" FT /translation="MTDMNPDIEKDQTSDEVTVETTSVFRADFLSELDAPAQAGTESAV FT SGVEGLPPGSALLVVKRGPNAGSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFRLE FT NNEFNVVDVGSLNGTYVNREPVDSAVLANGDEVQIGKFRLVFLTGPKQGEDDGSTGGP" FT CDS 149545..150288 FT /transl_table=11 FT /gene="Mb1859" FT /locus_tag="Mb1859" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1859, -, len: 247 aa. Equivalent to Rv1828, len: FT 247 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 247 aa overlap). Conserved hypothetical FT protein, equivalent to O32918|MLCB1788.35c|AL008609 FT hypothetical protein from Mycobacterium leprae (251 aa), FT FASTA scores: opt: 1397, E(): 0, (87.6% identity in 251 aa FT overlap)." FT /db_xref="GOA:P67670" FT /db_xref="InterPro:IPR000551" FT /db_xref="UniProtKB/Swiss-Prot:P67670" FT /protein_id="CAD94562.1" FT /translation="MSAPDSPALAGMSIGAVLDLLRPDFPDVTISKIRFLEAEGLVTPR FT RASSGYRRFTAYDCARLRFILTAQRDHYLPLKVIRAQLDAQPDGELPPFGSPYVLPRLV FT PVAGDSAGGVGSDTASVSLTGIRLSREDLLERSEVADELLTALLKAGVITTGPGGFFDE FT HAVVILQCARALAEYGVEPRHLRAFRSAADRQSDLIAQIAGPLVKAGKAGARDRADDLA FT REVAALAITLHTSLIKSAVRDVLHR" FT CDS 150407..150901 FT /transl_table=11 FT /gene="Mb1860" FT /locus_tag="Mb1860" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1860, -, len: 164 aa. Equivalent to Rv1829, len: FT 164 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 164 aa overlap). Conserved hypothetical FT protein, equivalent to O32917|MLCB1788.34|AL008609 FT Hypothetical protein from Mycobacterium leprae (164 aa), FT FASTA scores: opt: 1011, E(): 0, (95.1% identity in 164 aa FT overlap). Also present in Aquifex aeolicus, etc." FT /db_xref="InterPro:IPR003729" FT /db_xref="UniProtKB/TrEMBL:Q7TZG7" FT /protein_id="CAD94563.1" FT /translation="MGEVRVVGIRVEQPQNQPVLLLREANGDRYLPIWIGQSEAAAIAL FT EQQGVEPPRPLTHDLIRDLIAALGHSLKEVRIVDLQEGTFYADLIFDCNIKVSARPSDS FT VAIALRVGVPIYVEEAVLAQAGLLIPDESDEEATTAVREDEVEKFKEFLDSVSPDDFKA FT T" FT CDS 151193..151870 FT /transl_table=11 FT /gene="Mb1861" FT /locus_tag="Mb1861" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1861, -, len: 225 aa. Equivalent to Rv1830, len: FT 225 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 225 aa overlap). Conserved hypothetical FT protein, equivalent to Mycobacterium leprae hypothetical FT protein MLCB1788.33c|AL008609|O32916 (231 aa), FASTA FT scores: opt: 1307, E(): 0, (89.6% identity in 231 aa FT overlap)." FT /db_xref="GOA:P67672" FT /db_xref="InterPro:IPR000551" FT /db_xref="UniProtKB/Swiss-Prot:P67672" FT /protein_id="CAD94564.1" FT /translation="MTQLVTRARSARGSTLGEQPRQDQLDFADHTGTAGDGNDGAAAAS FT GPVQPGLFPDDSVPDELVGYRGPSACQIAGITYRQLDYWARTSLVVPSIRSAAGSGSQR FT LYSFKDILVLKIVKRLLDTGISLHNIRVAVDHLRQRGVQDLANITLFSDGTTVYECTSA FT EEVVDLLQGGQGVFGIAVSGAMRELTGVIADFHGERADGGESIAAPEDELASRRKHRDR FT KIG" FT CDS 151923..152180 FT /transl_table=11 FT /gene="Mb1862" FT /locus_tag="Mb1862" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1862, -, len: 85 aa. Equivalent to Rv1831, len: 85 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 85 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64900" FT /protein_id="CAD94565.1" FT /translation="MRLCVCSAVDWTTHRSSAGEFCGCQLRTPKEQYLSVNLSGTRTAR FT DYDASGKRWRPLAVLTRRWGKAIHLTVDRVAESLRRLACR" FT CDS 152229..155054 FT /transl_table=11 FT /gene="gcvB" FT /locus_tag="Mb1863" FT /product="Probable glycine dehydrogenase gcvB (Glycine FT decarboxylase) (Glycine cleavage system P-protein)" FT /EC_number="1.4.4.2" FT /note="Mb1863, gcvB, len: 941 aa. Equivalent to Rv1832, FT len: 941 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 941 aa overlap). Probable gcvB, glycine FT dehydrogenase [decarboxylating] (EC 1.4.4.2), highly FT similar to GCSP_ECOLI|P33195 glycine dehydrogenase FT (decarboxylating) from Escherichia coli (957 aa), FASTA FT scores: opt: 2194, E(): 0, (55.4% identity in 961 aa FT overlap). THE GLYCINE CLEAVAGE SYSTEM IS COMPOSED OF FOUR FT PROTEINS: P, T, L, AND H." FT /db_xref="GOA:Q7VET8" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:Q7VET8" FT /protein_id="CAD94566.1" FT /translation="MSDHSTFADRHIGLDSQAVATMLAVIGVDSLDDLAVKAVPAGILD FT TLTDTGAAPGLDSLPPAASEAEALAELRALADANTVAVSMIGQGYYDTHTPPVLLRNII FT ENPAWYTAYTPYQPEISQGRLEALLNFQTLVTDLTGLEIANASMLDEGTAAAEAMTLMH FT RAARGPVKRVVVDADVFTQTAAVLATRAKPLGIEIVTADLRAGLPDGEFFGAIAQLPGA FT SGRITDWSALVQQAHDRGALVAVGADLLALTLIAPPGEIGADVAFGTTQRFGVPMGFGG FT PHAGYLAVHAKHARQLPGRLVGVSVDSDGTPAYRLALQTREQHIRRDKATSNICTAQVL FT LAVLAAMYASYHGAGGLTAIARRVHAHAEAIAGALGDALVHDKYFDTVLARVPGRADEV FT LARAKANGINLWRVDADHVSVACDEATTDTHVAVVLDAFGVAAAAPAHADIATRTSEFL FT THPAFTQYRTETSMMRYLRALADKDIALDRSMIPLGSCTMKLNAAAEMESITWPEFGRQ FT HPFAPASDTAGLRQLVADLQSWLVLITGYDAVSLQPNAGSQGEYAGLLAIHEYHASRGE FT PHRDICLIPSSAHGTNAASAALAGMRVVVVDCHDNGDVDLDDLRAKVGEHAERLSALMI FT TYPSTHGVYEHDIAEICAAVHDAGGQVYVDGANLNALVGLARPGKFGGDVSHLNLHKTF FT CIPHGGGGPGVGPVAVRAHLAPFLPGHPFAPELPKGYPVSSAPYGSASILPITWAYIRM FT MGAEGLRAASLTAITSANYIARRLDEYYPVLYTGENGMVAHECILDLRGITKLTGITVD FT DVAKRLADYGFHAPTMSFPVAGTLMVEPTESESLAEVDAFCEAMIGIRAEIDKVGAGEW FT PVDDNPLRGAPHTAQCLLASDWDHPYTREQAAYPLGTAFRPKVWPAVRRIDGAYGDRNL FT VCSCPPVEAFA" FT CDS complement(155281..156141) FT /transl_table=11 FT /gene="Mb1864c" FT /locus_tag="Mb1864c" FT /product="Possible haloalkane dehalogenase" FT /EC_number="3.8.1.5" FT /note="Mb1864c, -, len: 286 aa. Equivalent to Rv1833c, len: FT 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 286 aa overlap). Possible haloalkane FT dehalogenase (EC 3.8.1.5). Similar to several haloalkane FT dehalogenase e.g. CAB45532.1|AJ243259 from Mycobacterium FT bovis (300 aa); also similar to LINB_PSEPA|P51698 FT 1,3,4,6-tetrachloro-1,4-cyclohexadien from Pseudomonas FT paucimobilis (295 aa), FASTA scores: opt: 314, E(): FT 1.5e-13, (33.1% identity in 281 aa overlap)." FT /db_xref="GOA:P64304" FT /db_xref="HSSP:1CV2" FT /db_xref="InterPro:IPR000639" FT /db_xref="UniProtKB/Swiss-Prot:P64304" FT /protein_id="CAD94567.1" FT /translation="MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPT FT WSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGLDRYL FT SMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRR FT NFFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVP FT ATLGTKPTLLIWGMKDVAFRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAI FT IERFG" FT CDS 156182..157048 FT /transl_table=11 FT /gene="Mb1865" FT /locus_tag="Mb1865" FT /product="Probable hydrolase" FT /EC_number="3.-.-.-" FT /note="Mb1865, -, len: 288 aa. Equivalent to Rv1834, len: FT 288 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 288 aa overlap). Probable hydrolase (EC FT 3.-.-.-), some similarity to haloalkane dehalogenases and FT D16262 hypothetical 38.9 kd protein (335 aa), FASTA scores: FT opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa FT overlap)." FT /db_xref="GOA:Q7VET7" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7VET7" FT /protein_id="CAD94568.1" FT /translation="MTSPSVREWRDGGRWLPTAVGKVFVRSGPGDTPTMLLLHGYPSSS FT FDFRAVIPHLTGQAWVTMDFLGFGLSDKPRPHRYSLLEQAHLVETVVAHTVTGAVVVLA FT HDMGTSVTTELLARDLDGRLPFDLRRAVLSNGSVILERASLRPIQKVLRSPLGPVAARL FT VSRGGFTRGFGRIFSPAHPLSAQEAQAQWELLCYNDGNRIPHLLISYLDERIRHAQRWH FT GAVRDWPKPLGFVWGLDDPVATTNVLNGLRELRPSAAVVELPGLGHYPQAEAPKAYAEA FT ALSLLVD" FT CDS complement(157053..158939) FT /transl_table=11 FT /gene="Mb1866c" FT /locus_tag="Mb1866c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1866c, -, len: 628 aa. Equivalent to Rv1835c, len: FT 628 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 628 aa overlap). Conserved hypothetical FT protein, some similarity to putative acylases e.g. G216374 FT glutaryl 7-aca acylase precursor (634 aa) FASTA scores, FT opt: 202, E(): 3.5e-06, (25.1% identity in 669 aa overlap). FT Also similar to Mycobacterium tuberculosis hypothetical FT proteins Rv2800 and Rv1215c." FT /db_xref="GOA:P0A5F6" FT /db_xref="InterPro:IPR000383" FT /db_xref="UniProtKB/Swiss-Prot:P0A5F6" FT /protein_id="CAD94569.1" FT /translation="MTRRGGSDAAWYSAPDQRSAYPRYRGMRYSSCYVTMRDGVRIAID FT LYLPAGLTSAARLPAILHQTRYYRSLQLRWPLRMLLGGKPLQHIAADKRRRRRFVASGY FT AWVDVDVRGSGASFGARVCEWSSDEIRDGAEIVDWIVRQPWCNGTVAALGNSYDGTSAE FT LLLVNQHPAVRVIAPCFSLFDVYTDIAFPGGIHAAWFTDTWGRYNEALDRNALHEVVGW FT WAKLPVTGMQPVQEDRDRSLRDGAIAAHRGNYDVHQIAGSLTFRDDVSASDPYRGQPDA FT RLEPIGTPIESGSINLISPHNYWRDVQASGAAIYSYSGWFDGGYAHAAIKRFLTVSTPG FT SHLILGPWNHTGGWRVDPLRGLSRPDFDHDGELLRFIDHHVKGADTGIGSEPPVHYFTM FT VENRWKSADTWPPPATTQSYYLSADRQLRPDAPDCDSGADEYVVDQTAGTGERSRWRSQ FT VGIGGHVCYPDRKAQDAKLLTYTSAPLDHPLEVTGHVVVTLFITSTSSDGTFFVYLEDV FT DPRGRVAYITEGQLRAIHRRLSDGPPPYRQVVPYRTFASGDAWPLVPGEIARLTFDLLP FT TSYLFQPGHRIRIAIAGADASHFAILPGCAPTVRVYRSRMHASRIDLPVIQP" FT CDS complement(158955..160988) FT /transl_table=11 FT /gene="Mb1867c" FT /locus_tag="Mb1867c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1867c, -, len: 677 aa. Equivalent to Rv1836c, len: FT 677 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 677 aa overlap). Conserved hypothetical FT protein. Equivalent to MLCB1788.28|AL008609 hypothetical FT protein from Mycobacterium leprae (710 aa), FASTA scores: FT opt: 2938, E(): 0, (66.0% identity in 714 aa overlap). FT Contains PS00036 bZIP transcription factors basic domain FT signature." FT /db_xref="InterPro:IPR002035" FT /db_xref="UniProtKB/TrEMBL:Q7TZG6" FT /protein_id="CAD94570.1" FT /translation="MGRHSKPDPEDSVDDLSDGHAAEQQHWEDISGSYDYPGVDQPDDG FT PLSSEGHYSAVGGYSASGSEDYPDIPPRPDWEPTGAEPIAAAPPPLFRFGHRGPGDWQA FT GHRSADGRRGVSIGVIVALVAVVVMVAGVILWCFFGDALSNRSHTAAARCVGGKDTVAV FT IADPSIADQVKESADSYNASAGPVGDRCVAVAVTSAGSDAVINGFIGKWPTELGGQPGL FT WIPSSSISAARLTGAAGSQAISDSRSLVISPVLLAVRPELQQALANQNWAALPGLQTNP FT NSLSGLDLPAWGSLRLAMPSSGNGDAAYLAGEAVAAASAPAGAPATAGIGAVRTLMGAR FT PKLADDSLTAAMDTLLKPGDVATAPVHAVVTTEQQLFQRGQSLSDAENTLGSWLPPGPA FT AVADYPTVLLSGAWLSQEQTSAASAFARYLHKPEQLAKLARAGFRVSDVKPPSSPVTSF FT PALPSTLSVGDDSMRATLADTMVTASAGVAATIMLDQSMPNDEGGNSRLSNVVAALENR FT IKAMPPSSVVGLWTFDGREGRTEVPAGPLADPVNGQPRPAALTAALGKQYSSGGGAVSF FT TTLRLIYQEMLANYHVGQANSVLVITAGPHTDQTLDGPGLQDFIRKSADPAKPIAVNII FT DFGADPDRATWEAVAQLSGGSYQNLETSASPDLATAVNIFLS" FT CDS complement(161108..163333) FT /transl_table=11 FT /gene="glcB" FT /locus_tag="Mb1868c" FT /product="PROBABLE MALATE SYNTHASE G GLCB" FT /EC_number="4.1.3.2" FT /note="Mb1868c, glcB, len: 741 aa. Equivalent to Rv1837c, FT len: 741 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 741 aa overlap). Probable glcB, malate FT synthase G (EC 4.1.3.2) (see citations below), highly FT similar to MASY_CORGL|P42450 malate synthase (738 aa), FT FASTA score: opt: 2961, E(): 0, (61.3% identity in 724 aa FT overlap). BELONGS TO THE MALATE SYNTHASE G FAMILY." FT /db_xref="GOA:P0A5J5" FT /db_xref="InterPro:IPR006253" FT /db_xref="UniProtKB/Swiss-Prot:P0A5J5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94571.1" FT /translation="MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVAD FT LTPQNQALLNARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSG FT VDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKV FT RGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTG FT AAESPTSVLLINHGLHIEILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDA FT ADKVLGYRNWLGLNKGDLAAAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRN FT VGHLMTNDAIVDTDGSEVFEGIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPK FT MHGPAEVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINT FT GFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWT FT MTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIE FT QLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWVDQGVGCSKVPDIHDVALMEDRA FT TLRISSQLLANWLRHGVITSADVRASLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLA FT AQELILSGAQQPNGYTEPILHRRRREFKARAAEKPAPSDRAGDDAAR" FT CDS complement(163609..164004) FT /transl_table=11 FT /gene="Mb1869c" FT /locus_tag="Mb1869c" FT /product="CONSERVED HYPOTHETICAL" FT /note="Mb1869c, -, len: 131 aa. Equivalent to Rv1838c, len: FT 131 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 131 aa overlap). Conserved hypothetical FT protein. Part of 14-membered Mycobacterium tuberculosis FT protein family with Rv2863|MTV003.09|AL008883 (126 aa), FT FASTA scores: opt: 293, E(): 1.5e-14, (38.2% identity in FT 123 aa overlap); Rv0749, Rv0277c, Rv2530c, etc. Also FT similar to AJ248288|CNSPAX06_181 Pyrococcus abyssi complete FT genome (136 aa), FASTA scores: opt: 197, E(): 2.2e-07, (33. FT 1% identity in 133 aa overlap)." FT /db_xref="InterPro:IPR006596" FT /db_xref="UniProtKB/Swiss-Prot:P64902" FT /protein_id="CAD94572.1" FT /translation="MILVDSNIPMYLVGASHPHKLDAQRLLESALSGGERLVTDAEVLQ FT EICHRYVAIKRREAIQPAFDAIIGVVDEVLPIERTDVEHARDALLRYQTLSARDALHIA FT VMAHHDITRLMSFDRGFDSYPGIKRLA" FT CDS complement(164001..164264) FT /transl_table=11 FT /gene="Mb1870c" FT /locus_tag="Mb1870c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1870c, -, len: 87 aa. Equivalent to Rv1839c, len: FT 87 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 87 aa overlap). Conserved hypothetical FT protein. Some similarity to G217008 CHO-ORF1 (279 aa), FT FASTA scores: opt: 86, E(): 13, (38.7% identity in 62 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZG5" FT /protein_id="CAD94573.1" FT /translation="MSKRLQVLLDPDEWEELREIARRHRTTVSEWVRRTLREAREREPR FT GDLDMKLRSVRAAARHEFPTADVEQMLEEIERGRGAEREGSR" FT CDS complement(164323..165723) FT /transl_table=11 FT /gene="PE_PGRS34" FT /locus_tag="Mb1871c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1871c, PE_PGRS34, len: 466 aa. Similar to Rv1840c, FT len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, FT (90.485% identity in 515 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins. Similar to many e.g. Y03A_MYCTU|Q10637 FT hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA FT scores: opt: 1693, E(): 0, (53.1% identity in 612 aa FT overlap); etc. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, an in-frame deletion of 147 bp leads FT to a longer protein compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 FT aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZG4" FT /protein_id="CAD94574.1" FT /translation="MSFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGAD FT EVSAAVADLFGAHAQAYQALSAQAALFHEQFVHAMTAGAGAYAGAEAADAAALDVLNGP FT FQALFGRPLIGDGANGAPGQPGGPGGLLYGNGGNGGNGGIGQPGGAGGDAGLIGNGGNG FT GIGGPGATGLAGGAGGLGKAGFAGGAGGTGGTGGLLYGNGGNGGNVPSGAADGGAGGDA FT RLIGNGGDGGSVGAAPTGIGNGGNGGNGGWLYGDGGSGGSTLQGFSDGGTGGNAGMFGD FT GGNGGFSFFDGNGGDGGTGGTLIGNGGDGGNSVQTDGFLRGHGGDGGNAVGLIGNGGAG FT GAGSAGTGVFAPGGGSGGNGGNGALLVGNGGAGGSGGPTQIPSVAVPVTGAGGTGGNGG FT TAGLIGNGGNGGAAGVSGDGTPGTGGNGGYAQLIGDGGDGGPGDSGGPGGSGGTGGTLA FT GQNGSPGG" FT CDS complement(165886..166935) FT /transl_table=11 FT /gene="Mb1872c" FT /locus_tag="Mb1872c" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1872c, -, len: 349 aa. Equivalent to Rv1841c, len: FT 345 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.9% identity in 349 aa overlap). Conserved hypothetical FT membrane protein. Some similarity to O07585|YHDP_BACSU FT HYPOTHETICAL 49.9 KD PROTEIN from Bacillus subtilis (444 FT aa), FASTA scores: opt: 620, E(): 0, (31.1% identity in 350 FT aa overlap). Also similar to other Mycobacterium FT tuberculosis proteins e.g. Rv1842c, Rv2366c. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 12 FT bp in-frame insertion leads to a longer product compared to FT its homolog in Mycobacterium tuberculosis strain H37Rv (349 FT aa versus 345 aa)." FT /db_xref="InterPro:IPR002550" FT /db_xref="UniProtKB/TrEMBL:Q7TZG3" FT /protein_id="CAD94575.1" FT /translation="MDVLSAVLLALLLIGANAFFVGAEFALISARRDRLEALAEQGKAT FT AVTVIRAGEQLPAMLTGAQLGVTVSSILLGRVGEPAVVKLLQLSFGLSGVPPALLHTLS FT LAVALAIVVALHVLLGEMVPKNIALAGPERTAMLLVPPYLVYVRLARPFIAFYNNCANA FT ILRLVGVQPKDELDIAVSTAELSEMIAESLSEGLLDHEEHTRLTRALRIRTRLVADVAV FT PLVNIRAVQVSAVGSGPTIGGVEQALAQTGYSRFPVVDRGGRFIGYLHIKDVLTLGDNP FT QTVIDLAVVRPLPRVPQSLPLADALSRMRRINSHLALVTADNGSVVGMVALEDVVEDLV FT GTMRDGTHR" FT CDS complement(166935..168302) FT /transl_table=11 FT /gene="Mb1873c" FT /locus_tag="Mb1873c" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1873c, -, len: 455 aa. Equivalent to Rv1842c, len: FT 455 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 455 aa overlap). Conserved hypothetical FT membrane protein. Similar to Z99109|0O7589 Potential FT integral membrane protein from Bacillus subtilis (461 aa), FT FASTA scores: opt: 723, E(): 0, (31.2% identity in 449 aa FT overlap). Similar to other Mycobacterium tuberculosis FT putative integral membrane proteins e.g. Rv2366c, Rv1841c." FT /db_xref="GOA:Q7TZG2" FT /db_xref="InterPro:IPR002550" FT /db_xref="UniProtKB/TrEMBL:Q7TZG2" FT /protein_id="CAD94576.1" FT /translation="MNLTDTVATILAILALTAGTGVFVAAEFSLTALDRSTVEANARGG FT TSRDRFIQRAHHRLSFQLSGAQLGISITTLATGYLTEPLVAELPHPGLVAVGMSDRVAD FT GLITFFALVIVTSLSMVFGELVPKYLAVARPLRTARSVVAGQVLFSLLLTPAIRLTNGA FT ANWIVRRLGIEPAEELRSARTPQELVSLVRSSARSGALDDATAWLMRRSLQFGALTAEE FT LMTPRSKIVALQTDDTIADLVAAAAASGFSRFPVVEGDLDATVGIVHVKQVFEVPPGDR FT AHTLLTTVAEPVAVVPSTLDGDAVMAQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIV FT GDVRDEHDDATPDVVAAGNGWRVSGLLRIDEVASATGYRAPDGPYETIGGLVLRELGHI FT PVAGETVELTALDQDGLPDDSMRWLATVIQMDGRRIDSLELIKMGGHADPGSGRGR" FT CDS complement(168476..169915) FT /transl_table=11 FT /gene="guaB1" FT /locus_tag="Mb1874c" FT /product="PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE FT GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)" FT /EC_number="1.1.1.205" FT /note="Mb1874c, guaB1, len: 479 aa. Equivalent to Rv1843c, FT len: 479 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 479 aa overlap). Probable guaB1, FT inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). FT Similar to others e.g. IMDH_BACSU|P21879 from Bacillus FT subtilis (513 aa), FASTA score: opt: 904, E(): 0, (37.8% FT identity in 471 aa overlap). Similar to other Mycobacterium FT tuberculosis proteins e.g. guaB2, Rv3411c." FT /db_xref="GOA:P65173" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR005991" FT /db_xref="UniProtKB/Swiss-Prot:P65173" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94577.1" FT /translation="MMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGTT FT IPVVVANMTAVAGRRMAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTPVTLA FT PDDSVSDAMALIHKRAHGVAVVILEGRPIGLVRESSCLGVDRFTRVRDIAVTDYVTAPA FT GTEPRKIFDLLEHAPVDVAVLTDADGTLAGVLSRTGAIRAGIYTPATDSAGRLRIGAAV FT GINGDVGAKARALAEAGVDVLVIDTAHGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEG FT TRDLLKAGANVVKVGVGPGAMCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIR FT HPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTGA FT DNPFDRARKALFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVGASNLAELHER FT AVVGVQSGAGFAEGHPLPAGW" FT CDS complement(169281..171338) FT /transl_table=11 FT /gene="gnd1" FT /locus_tag="Mb1875c" FT /product="PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1" FT /EC_number="1.1.1.44" FT /note="Mb1875c, gnd1, len: 705 aa. Similar to 5' end of FT Rv1844c, len: 485 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.5% identity in 404 aa overlap). Probable FT gnd1, 6-phosphogluconate dehydrogenase (EC 1.1.1.44). FT Similar to others e.g. 6PGD_ECOLI|P00350 from Escherichia FT coli (468 aa), FASTA scores: opt: 1661, E(): 0, (53.6% FT identity in 466 aa overlap); etc. Also similar to FT Rv1122|MTCY22G8.11|gnd2 PROBABLE 6-PHOSPHOGLUCONATE FT DEHYDROGENASE, DECARBOXYLATING from Mycobacterium FT tuberculosis (340 aa), FASTA score: (33.0% identity in 351 FT aa overlap). Note that Rv1844c is most similar to gnd's FT from Gram negative organisms, while Rv1122|MTCY22G8.11|gnd2 FT is most similar to gnd's from Gram positive organisms. FT BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT single base insertion (c-*) leads to a longer product with FT a different COOH part compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (705 aa versus 485 FT aa)." FT /db_xref="GOA:Q7TZG1" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZG1" FT /protein_id="CAD94578.1" FT /translation="MGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETI FT PEFLAALEKPRRVLIMVKAGEATDAVINELADAMEPGDIIIDGGNALYTDTMRREKAMR FT ERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCTHIGPD FT GSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLVEIT FT AEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSV FT GQRSAASGLASGKLGEQPADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWDIT FT PGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRAPSNRRSTVGGVWCRRR FT PNWVSRPRDSRRPCRITTRCAPRGCPLHSPRPSATSSAHTPTAGSTNQASSTHYGVQTA FT PKYRCSGLELKGGKGVSDEISRRAPTRVRPDIQRRVHRSEPIRGRVALRRRFVHRRRLG FT HHHSGSGRQYDRGSRAADGRDGRPPRWHRNPAAGSADPGGKADGGVRQKPGPGARHPSD FT AGTRRFGVRRHGAHPQARTWRRGGHPRGSPDRIGARIVLPGRGSLHPGARYRRDGLCDR FT SSGNRATQDLRPAGARPGRRCGADRRRRHVGGSAKPHRGYPRRYLHPGHR" FT CDS complement(171428..172378) FT /transl_table=11 FT /gene="Mb1876c" FT /locus_tag="Mb1876c" FT /product="CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN" FT /note="Mb1876c, -, len: 316 aa. Equivalent to Rv1845c, len: FT 316 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 316 aa overlap). Conserved hypothetical FT transmembrane protein. Equivalent to MLCB1788.18|AL008609 FT Hypothetical protein from Mycobacterium leprae (316 aa), FT FASTA scores: opt: 1762, E(): 0, (87.6% identity in 314 aa FT overlap). Similar to proteins in Streptomyces coelicolor FT e.g. SC10A7.04|AL078618.1." FT /db_xref="GOA:Q7TZG0" FT /db_xref="InterPro:IPR001915" FT /db_xref="UniProtKB/TrEMBL:Q7TZG0" FT /protein_id="CAD94579.1" FT /translation="MSALAFTILAVLLAGPTPALLARATWPLRAPRAAMVLWQAIALAA FT VLSSFSAGIAIASRLLMPGPDGRPTTSFVGAAGRLGWPLWAAYITVFALTVLVGARLAV FT AVVRVATATRRRRAHHRMVVDLVGVGHNGALAQPCARARDLRVLDVAQPLAYCLPGVRS FT RVVVSEGTLTALADAEVAAILTHERAHLRARHDLVLEAFTAVHAAFPRLVRSANALGAV FT QLLVELLADDAAVRAAGRTPLARALVACASGRAPSGALAVGGPSTVLRVRRLSGRGNSA FT VLSAAAYLAAAAVLVVPTVALAVPWLTQLQRLFIA" FT CDS complement(172393..172809) FT /transl_table=11 FT /gene="Mb1877c" FT /locus_tag="Mb1877c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1877c, -, len: 138 aa. Equivalent to Rv1846c, len: FT 138 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 138 aa overlap). Possible FT transcriptional regulatory protein. Equivalent to FT MLCB1788.17|AL008609 hypothetical protein from FT Mycobacterium leprae (142 aa), FASTA scores: opt: 736 E(): FT 0, (95.1% identity in 123 aa overlap). Also similar to FT BLAI_BACLI|P06555 penicillinase repressor (128 aa), fasta FT scores: opt: 114, E(): 0.12, (23.7% identity in 131 aa FT overlap)." FT /db_xref="GOA:Q7TZF9" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7TZF9" FT /protein_id="CAD94580.1" FT /translation="MAKLTRLGDLERAVMDHLWSRTEPQTVRQVHEALSARRDLAYTTV FT MTVLQRLAKKNLVLQIRDDRAHRYAPVHGRDELVAGLMVDALAQAEYSGSRQAALVHFV FT ERVGADEADALRRALAELEAGHGNRPPAGAATET" FT CDS 173086..173508 FT /transl_table=11 FT /gene="Mb1878" FT /locus_tag="Mb1878" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1878, -, len: 140 aa. Equivalent to Rv1847, len: FT 140 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 140 aa overlap=. Conserved hypothetical FT protein, possible thioesterase, some similarity to YBDB FT proteins of Escherichia coli and H. influenzae e.g. FT P15050|YBDB_ECOLI HYPOTHETICAL 15.0 KD PROTEIN IN ENTA-CSTA FT INTERGENIC REGION (137 aa), FASTA scores: opt: 232, E(): FT 6.6e-10, (35.8% identity in 106 aa overlap); C48956|G142208 FT thioesterase from Arthrobacter sp (151 aa), FASTA score: FT opt: 254, E(): 1.7e-11, (33.3% identity in 138 aa overlap). FT Also similar to AF064959|AF064959_1 hypothetical protein FT from Coxiella burnetii (148 aa), FASTA score: opt: 264, FT E(): 9.3e- 12, (36.8% identity in 117 aa overlap)." FT /db_xref="HSSP:1VH9" FT /db_xref="InterPro:IPR006683" FT /db_xref="UniProtKB/TrEMBL:Q7TZF8" FT /protein_id="CAD94581.1" FT /translation="MQPSPDSPAPLNVTVPFDSELGLQFTELGPDGARAQLDVRPKLLQ FT LTGVVHGGVYCAMIESIASMAAFAWLNSHGEGGSVVGVNNNTDFLRSISSGMVYGTAEP FT LHRGRRQQLWLVTITDDTDRVVARGQVRLQNLEARP" FT CDS 173557..173859 FT /transl_table=11 FT /gene="ureA" FT /locus_tag="Mb1879" FT /product="Urease gamma subunit ureA (Urea amidohydrolase)" FT /EC_number="3.5.1.5" FT /note="Mb1879, ureA, len: 100 aa. Equivalent to Rv1848, FT len: 100 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 100 aa overlap). ureA, urease gamma FT subunit (EC 3.5.1.5). Similar to URE3_MYCTU|P50043 from FT Mycobacterium tuberculosis (100 aa), FASTA scores: opt: FT 630, E(): 1.3e-36, (99.0% identity in 100 aa overlap). FT BELONGS TO THE UREASE GAMMA SUBUNIT FAMILY." FT /db_xref="GOA:P0A677" FT /db_xref="HSSP:1UBP" FT /db_xref="InterPro:IPR002026" FT /db_xref="UniProtKB/Swiss-Prot:P0A677" FT /protein_id="CAD94582.1" FT /translation="MRLTPHEQERLLLSYAAELARRRRARGLRLNHPEAIAVIADHILE FT GARDGRTVAELMASGREVLGRDDVMEGVPEMLAEVQVEATFPDGTKLVTVHQPIA" FT CDS 173856..174170 FT /transl_table=11 FT /gene="ureB" FT /locus_tag="Mb1880" FT /product="Urease beta subunit ureB" FT /EC_number="3.5.1.5" FT /note="Mb1880, ureB, len: 104 aa. Equivalent to Rv1849, FT len: 104 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 104 aa overlap). ureB, urease beta FT subunit (EC 3.5.1.5). Identical to URE2_MYCTU|P50048 urease FT beta subunit from Mycobacterium tuberculosis (100 aa). FT BELONGS TO THE UREASE GAMMA SUBUNIT FAMILY." FT /db_xref="GOA:P0A663" FT /db_xref="HSSP:1EJX" FT /db_xref="InterPro:IPR002019" FT /db_xref="UniProtKB/Swiss-Prot:P0A663" FT /protein_id="CAD94583.1" FT /translation="MIPGEIFYGSGDIEMNAAALSRLQMRIINAGDRPVQVGSHVHLPQ FT ANRALSFDRATAHGYRLDIPAATAVRFEPGIPQIVGLVPLGGRREVPGLTLNPPGRLDR FT " FT CDS 174170..175903 FT /transl_table=11 FT /gene="ureC" FT /locus_tag="Mb1881" FT /product="Urease alpha subunit ureC (Urea amidohydrolase)" FT /EC_number="3.5.1.5" FT /note="Mb1881, ureC, len: 577 aa. Equivalent to Rv1850, FT len: 577 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 577 aa overlap). ureC, urease alpha FT subunit (EC 3.5.1.5). Similar to URE1_MYCTU|P50042 from M. FT tuberculosis (577 aa), FASTA scores: opt: 3794, E(): 0, FT (98.3% identity in 577 aa overlap). Contains PS00145 Urease FT active site motif. BELONGS TO THE UREASE FAMILY." FT /db_xref="GOA:P0A661" FT /db_xref="HSSP:1EJX" FT /db_xref="InterPro:IPR017950" FT /db_xref="UniProtKB/Swiss-Prot:P0A661" FT /protein_id="CAD94584.1" FT /translation="MARLSRERYAQLYGPTTGDRIRLADTNLLVEVTEDRCGGPGLAGD FT EAVFGGGKVLRESMGQGRASRADGAPDTVITGAVIIDYWGIIKADIGIRDGRIVGIGKA FT GNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHVHLICPQIIVEALAAGTTTIIG FT GGTGPAEGTKATTVTPGEWHLARMLESLDGWPVNFALLGKGNTVNPDALWEQLRGGASG FT FKLHEDWGSTPAAIDTCLAVADVAGVQVALHSDTLNETGFVEDTIGAIAGRSIHAYHTE FT GAGGGHAPDIITVAAQPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLAFA FT ESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMKARRGALEGDP FT SGSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKLADLVLWEPAFFGVRPHVVL FT KGGAIAWAAMGDANASIPTPQPVLPRPMFGAAAATAAATSVHFVAPQSIDARLADRLAV FT NRGLAPVADVRAVGKTDLPLNDALPSIEVDPDTFTVRIDGQVWQPQPAAELPMTQRYFL FT F" FT CDS 175903..176538 FT /transl_table=11 FT /gene="ureF" FT /locus_tag="Mb1882" FT /product="Urease accessory protein uref" FT /note="Mb1882, ureF, len: 211 aa. Equivalent to Rv1851, FT len: 211 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 211 aa overlap). ureF, urease accessory FT protein. Identical to UREF_MYCTU|P50050 from M. FT tuberculosis." FT /db_xref="GOA:Q7VET6" FT /db_xref="InterPro:IPR002639" FT /db_xref="UniProtKB/Swiss-Prot:Q7VET6" FT /protein_id="CAD94585.1" FT /translation="MTSLAVLLTLADSRLPTGAHVHSGGIEEAIAAGLVTGLATLEAFL FT KRRVRTHGLLTASIAAAVHRGELAVDDADRETDARTPAPAARHASRSQGRGLIRLARRV FT WPDSGWEELGPRPHLAVVAGRVGALSGLAPEHNALHLVYITMTGSAIAAQRLLALDPAE FT VTVVTFQLSELCEQIAQEATAGLADLSDPLLDTLAQRHDERVRPLFVS" FT CDS 176549..177223 FT /transl_table=11 FT /gene="ureG" FT /locus_tag="Mb1883" FT /product="Urease accessory protein ureG" FT /note="Mb1883, ureG, len: 224 aa. Equivalent to Rv1852, FT len: 224 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 224 aa overlap). ureG, urease accessory FT protein. Identical to UREG_MYCTU|P50051 from M. FT tuberculosis. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). BELONGS TO THE UREG FAMILY." FT /db_xref="GOA:P0A665" FT /db_xref="InterPro:IPR004400" FT /db_xref="UniProtKB/Swiss-Prot:P0A665" FT /protein_id="CAD94586.1" FT /translation="MATHSHPHSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAAL FT CRQLRGELSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITANLD FT AIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDKVPRKGGPGVTYS FT DLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSLTEDPAASDVVAWVRSQLAAD FT GV" FT CDS 177231..177857 FT /transl_table=11 FT /gene="ureD" FT /locus_tag="Mb1884" FT /product="Probable urease accessory protein ureD" FT /note="Mb1884, ureD, len: 208 aa. Equivalent to Rv1853, FT len: 208 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 208 aa overlap). ureD, probable urease FT accessory protein. Similar to URED_YEREN|P42868 Urease FT operon ureD protein from Yersinia enterocolitica (325 aa), FT Fasta scores: opt: 114, E(): 0.37, (25.2% identity in 119 FT aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7VET5" FT /protein_id="CAD94587.1" FT /translation="MVASPNRLPRIDCRGGVQARRTAPDTVHLVSAAATPLGGDTMRIR FT VIVERGAQLRLRSAAATVALPGVDTLTSHAHWEIDVTGTLDVDLEPTVVAASARHLSHA FT TLRLHDDGRVRLRERVQIGRCNEREGFWSSSLQADRHGRPLLRHRVELGAGSLADDVIA FT APRATISELRYPATAFTDAIDARSTVLALAGGGTLSTWQADRLPG" FT CDS complement(177860..179251) FT /transl_table=11 FT /gene="ndh" FT /locus_tag="Mb1885c" FT /product="PROBABLE NADH DEHYDROGENASE NDH" FT /EC_number="1.6.99.3" FT /note="Mb1885c, ndh, len: 463 aa. Equivalent to Rv1854c, FT len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 463 aa overlap). Probable ndh, NADH FT dehydrogenase (EC 1.6.99.3) (see citations below), similar FT to several e.g. S74826 NADH dehydrogenase from FT Synechocystis sp. (445 aa), FASTA score: opt: 1228, E(): 0, FT (46.3% identity in 432 aa overlap). Highly similar to FT Rv0392c|Z84725|g1817703 from Mycobacterium tuberculosis FT (470 aa), FASTA scores: opt: 1911, E(): 0, (64.7% identity FT in 459 aa overlap); and Rv1812c." FT /db_xref="GOA:Q7TZF7" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:Q7TZF7" FT /protein_id="CAD94588.1" FT /translation="MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIAR FT TTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSELL FT GHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERSSD FT PERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLP FT PMGAKLGQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVS FT ASWLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQGAIQGA FT KYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVL FT HLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAAS FT AKVAS" FT CDS complement(179392..180315) FT /transl_table=11 FT /gene="Mb1886c" FT /locus_tag="Mb1886c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1886c, -, len: 307 aa. Equivalent to Rv1855c, len: FT 307 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 307 aa overlap). Possible FT oxidoreductase (EC 1.-.-.-), possibly a monooxygenase. FT Contains PS00217 Sugar transport proteins signature 2, FT probably fortuitously. Similar to G487716 (78-11) FT LINCOMYCIN PRODUCTION GENES (29.2% identity in 154 aa FT overlap). Also similar to other Mycobacterium tuberculosis FT proteins e.g. Rv0953c, Rv0791c, Rv0132c, Rv2951c, etc." FT /db_xref="GOA:Q7TZF6" FT /db_xref="InterPro:IPR019952" FT /db_xref="UniProtKB/TrEMBL:Q7TZF6" FT /protein_id="CAD94589.1" FT /translation="MTIRLGLQIPNFSYGTGVEKLFPSVIAQAREAEAAGYDSLFVMDH FT FYQLPMLGTPDQPMLEAYTALGALATATERLQLGALVTGNTYRSPTLLAKIITTLDVVS FT AGRAILGIGAGWFELEHRQLGFEFGTFSDRFNRLEEALQILEPMVKGERPTFFGDWYTT FT ESAMAEPRYRDRIPILIGGGGEKKTFAIAARFADHLNIVAAVDELPRKMRALAARCDEA FT GRDRSTLQTSLLLTVMIDETLSPDAIPAEMSGRVVVGSPAQIADQIQAKVLDAGVDGLI FT INLAPHGYLPGVITTAAEALRPLLGV" FT CDS complement(180354..181031) FT /transl_table=11 FT /gene="Mb1887c" FT /locus_tag="Mb1887c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1887c, -, len: 225 aa. Equivalent to Rv1856c, len: FT 225 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 225 aa overlap). Possible oxidoreductase FT (EC 1.-.-.-). Equivalent to MLCB1788.11c|AL008609 FT OXIDOREDUCTASE from Mycobacterium leprae (224 aa), FASTA FT scores: opt: 1211, E(): 0; (80.4% identity in 224 aa FT overlap). Some similarity to dehydrogenases of short-chain FT dehydrogenase/reductase family and fatty-acyl CoA FT reductases e.g. P16543|DHK2_STRVN GRANATICIN POLYKETIDE FT SYNTHASE P (249 aa), FASTA score: opt: 194, E(): 1.1e-05, FT (32.5% identity in 237 aa overlap)." FT /db_xref="GOA:Q7TZF5" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZF5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94590.1" FT /translation="MAVEVLVTGGDTDLGRTMAEGFRNDGHKVTLVGARRGDLEVAAKE FT LDVDAVVCDTTDPTSLTEARGLFPRHLDTIVNVPAPSWDAGDPRAYSVSDTANAWRNAL FT DATVLSVVLTVQSVGDHLRSGGSIVSVVAENPPAGGAESAIKAALSNWIAGQAAVFGTR FT GITINTVACGRSVQTGYEGLSHTPAPVAAEIARLALFLTTPAARHITGQTLHVSHGALA FT HFG" FT CDS 181193..181978 FT /transl_table=11 FT /gene="modA" FT /locus_tag="Mb1888" FT /product="PROBABLE MOLYBDATE-BINDING LIPOPROTEIN MODA" FT /note="Mb1888, modA, len: 261 aa. Equivalent to Rv1857, FT len: 261 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 261 aa overlap). Probable modA, FT molybdate-binding protein attached to membrane by FT lipid-modified N-terminal cysteine (contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site), FT component of molybdate transport system (see citation FT below). Shows strong similarity to precursors of FT periplasmic molybdate/sulphate binding proteins e.g. FT O31229|Y10817|ANY108174 ModA from Arthrobacter FT nicotinovorans (260 aa), FASTA score: opt: 725, E(): 0, FT (47.8% identity in 249 aa overlap)." FT /db_xref="GOA:P0A5Y1" FT /db_xref="HSSP:1WOD" FT /db_xref="InterPro:IPR006059" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Y1" FT /protein_id="CAD94591.1" FT /translation="MRWIGLSTGLVSAMLVAGLVACGSNSPASSPAGPTQGARSIVVFA FT AASLQSAFTQIGEQFKAGNPGVNVNFAFAGSSELATQLTQGATADVFASADTAQMDSVA FT KAGLLAGHPTNFATNTMVIVAAAGNPKKIRSFADLTRPGLNVVVCQPSVPCGSATRRIE FT DATGIHLNPVSEELSVTDVLNKVITGQADAGLVYVSDALSVATKVTCVRFPEAAGVVNV FT YAIAVLKRTSQPALARQFVAMVTAAAGRRILDQSGFAKP" FT CDS 181981..182775 FT /transl_table=11 FT /gene="modB" FT /locus_tag="Mb1889" FT /product="PROBABLE MOLBDENUM-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER MODB" FT /note="Mb1889, modB, len: 264 aa. Equivalent to Rv1858, FT len: 264 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 264 aa overlap). Probable modB, FT molybdenum-transport integral membrane protein ABC FT transporter (see citation below), similar to others e.g. FT Y10817|ANY108175 ModB from Arthrobacter (239 aa), FASTA FT scores: opt: 937, E(): 0, (67.8% identity in 230 aa FT overlap); etc. Similar to other Mycobacterium tuberculosis FT transport proteins e.g. Rv2039c, Rv2316, etc." FT /db_xref="GOA:P0A625" FT /db_xref="InterPro:IPR011867" FT /db_xref="UniProtKB/Swiss-Prot:P0A625" FT /protein_id="CAD94592.1" FT /translation="MHPPTDLPRWVYLPAIAGIVFVAMPLVAIAIRVDWPRFWALITTP FT SSQTALLLSVKTAAASTVLCVLLGVPMALVLARSRGRLVRSLRPLILLPLVLPPVVGGI FT ALLYAFGRLGLIGRYLEAAGISIAFSTAAVVLAQTFVSLPYLVISLEGAARTAGADYEV FT VAATLGARPGTVWWRVTLPLLLPGVVSGSVLAFARSLGEFGATLTFAGSRQGVTRTLPL FT EIYLQRVTDPDAAVALSLLLVVVAALVVLGVGARTPIGTDTR" FT CDS 182782..183891 FT /transl_table=11 FT /gene="modC" FT /locus_tag="Mb1890" FT /product="PROBABLE MOLYBDENUM-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER MODC" FT /note="Mb1890, modC, len: 369 aa. Equivalent to Rv1859, FT len: 369 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 369 aa overlap). Probable modC, FT molybdenum-transport ATP-binding protein ABC transporter FT (see citation below), similar to others e.g. FT Y10817|ANY108176 ModC from Arthrobacter (349 aa), FASTA FT scores: opt: 895, E(): 0, (46.0% identity in 361 aa FT overlap); etc. Shows similarity to other Mycobacterium FT tuberculosis ABC-transporter proteins e.g. Rv0073, Rv1238, FT Rv2564, etc. Contains both PS00017 ATP/GTP-binding site FT motif A (P-loop) and PS00211 ABC transporters family FT signatures involved in molybdate uptake. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7TZF4" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TZF4" FT /protein_id="CAD94593.1" FT /translation="MSKLQLRAVVADRRLDVEFSVSAGEVLAVLGPNGAGKSTALHVIA FT GLLRPDAGLVRLGDRVLTDTEAGVNVATHDRRVGLLLQDPLLFPHLSVAKNVAFGPQCR FT RGMFGSGRARTRASALRWLREVNAEQFADRKPRQLSGGQAQRVAIARALAAEPDVLLLD FT EPLTGLDVAAAAGIRSVLRSVVARSGCAVVLTTHDLLDVFTLADRVLVLESGTIAEIGP FT VADVLTAPRSRFGARIAGVNLVNGTIGPDGSLRTQSGAHWYGTPVQDLPTGHEAIAVFP FT PTAVAVYPEPPHGSPRNIVGLTVAEVDTRGPMVLVRGHDQPGGAPGLAACITVDAATEL FT RVAPGSRVWFSVKAQEVALHPAPHQHASS" FT CDS 183944..184921 FT /transl_table=11 FT /gene="apa" FT /locus_tag="Mb1891" FT /standard_name="mpt32; modD" FT /product="ALANINE AND PROLINE RICH SECRETED PROTEIN APA FT (FIBRONECTIN ATTACHMENT PROTEIN) (Immunogenic protein FT MPT32) (Antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa FT antigen)" FT /note="Mb1891, apa, len: 325 aa. Equivalent to Rv1860, len: FT 325 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 325 aa overlap). apa (alternate gene FT names: mpt32, modD), Ala-, Pro-rich 45/47 kDa secreted FT protein, very similar to P46842|N43L_MYCLE from FT Mycobacterium leprae (287 aa), FASTA scores: opt: 1166, FT E(): 0, (66.4% identity in 298 aa overlap). Known to be FT glycosylated fibronectin-binding protein (see some FT citations). TBparse score is 0.924." FT /db_xref="GOA:O30620" FT /db_xref="InterPro:IPR010801" FT /db_xref="UniProtKB/Swiss-Prot:O30620" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94594.1" FT /translation="MHQVDPNLTRRKGRLAALAIAAMASASLVTVAVPATANADPEPAP FT PVPTTAASPPSTAAAPPAPATPVAPPPPAAANTPNAQPGDPNAAPPPADPNAPPPPVIA FT PNAPQPVRIDNPVGGFSFALPAGWVESDAAHLDYGSALLSKTTGDPPFPGQPPPVANDT FT RIVLGRLDQKLYASAEATDSKAAARLGSDMGEFYMPYPGTRINQETVSLDANGVSGSAS FT YYEVKFSDPSKPNGQIWTGVIGSPAANAPDAGPPQRWFVVWLGTANNPVDKGAAKALAE FT SIRPLVAPPPAPAPAPAEPAPAPAPAGEVAPTPTTPTPQRTLPA" FT CDS 185373..185678 FT /transl_table=11 FT /gene="Mb1892" FT /locus_tag="Mb1892" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb1892, -, len: 101 aa. Equivalent to Rv1861, len: FT 101 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 101 aa overlap). Probable conserved FT transmembrane protein, showing weak similarity to FT AE002069|AE002069_10 hypothetical protein from Deinococcus FT radiodurans (146 aa), FASTA scores: opt: 154, E(): 0.0027, FT (30.8% identity in 104 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7TZF3" FT /db_xref="InterPro:IPR007341" FT /db_xref="UniProtKB/TrEMBL:Q7TZF3" FT /protein_id="CAD94595.1" FT /translation="MDITATTEFSAMNLDGKTGIGWLGYIVIGGIAGWLASKIVKGGGS FT GILMNVVIGVVGAFGAGLVLNALGVDVNHGGYWFTFFVALGGAVVLLWIVGMVRKT" FT CDS 185753..186793 FT /transl_table=11 FT /gene="adhA" FT /locus_tag="Mb1893" FT /product="Probable alcohol dehydrogenase adhA" FT /EC_number="1.1.1.1" FT /note="Mb1893, adhA, len: 346 aa. Equivalent to Rv1862, FT len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 346 aa overlap=. Probable adhA, alcohol FT dehydrogenase (EC 1.1.1.1), similar to ADH2_BACST|P42327 FT alcohol dehydrogenase (339 aa), FASTA scores: opt: 630, FT E(): 2.4e-32 (34.4% identity in 320 aa overlap). Contains FT PS00059 Zinc-containing alcohol dehydrogenases signature." FT /db_xref="GOA:Q7VET4" FT /db_xref="InterPro:IPR014187" FT /db_xref="UniProtKB/TrEMBL:Q7VET4" FT /protein_id="CAD94596.1" FT /translation="MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAV FT HACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVIEVGSAVGAAAGGEFDRGDRVGIAW FT LRHTCGVCKYCRRGSENLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSELAPL FT LCAGIIGYRSLLRTELPPGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLAL FT QLGAASAQDAADRPPVPLDAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNY FT QQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPEYPLGQADRALGDLSAGRIAG FT AAVLLI" FT CDS complement(186800..187570) FT /transl_table=11 FT /gene="Mb1894c" FT /locus_tag="Mb1894c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb1894c, -, len: 256 aa. Equivalent to Rv1863c, len: FT 256 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 256 aa overlap). Probable conserved FT integral membrane protein, similar to FT Rv0804|Z95618|MTCY7H7A.05 Hypothetical protein from FT Mycobacterium tuberculosis (209 aa), FASTA scores: opt: FT 199, E(): 1e-06, (33.2% identity in 220 aa overlap); and FT Rv0658c." FT /db_xref="GOA:Q7TZF2" FT /db_xref="InterPro:IPR003675" FT /db_xref="UniProtKB/TrEMBL:Q7TZF2" FT /protein_id="CAD94597.1" FT /translation="MSDHLTACAAVHPGPLVSHLSVMHRFRIYVDIAVVVLVLVLTNLI FT AHFTTPWASIATVPAAAVGLVILVRSRGLGWAELGLSRQHWKSGLVYALAAVALVVAVI FT SVGVLLPITRPMFMNHHYATISGAVIASMVMIPLQTVIPEELAFRGVLHGALNRAWGFR FT GVAVAGSVLFGLWHIATSLGLTSSNVGFTRLFGGGIIGLVAGVMLAVLATGVAGFVFSW FT LRRRSGSLIAPIALHWSLNGMGALAAALVWHLST" FT CDS complement(187563..188318) FT /transl_table=11 FT /gene="Mb1895c" FT /locus_tag="Mb1895c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1895c, -, len: 251 aa. Equivalent to Rv1864c, len: FT 251 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 251 aa overlap). Conserved hypothetical FT protein. Similar to other hypothetical proteins e.g. FT AL031317|SC6G4.43 from Streptomyces coelicolor cosmid 6G FT (233 aa), FASTA scores: opt: 716, E(): 0, (54.4% identity FT in 215 aa overlap); also P43976|YIIM_HAEIN hypothetical FT protein hi0278 (221 aa), FASTA scores: opt: 223, E(): FT 3.8e-08, (29.5% identity in 173 aa overlap)." FT /db_xref="GOA:Q7TZF1" FT /db_xref="InterPro:IPR015808" FT /db_xref="UniProtKB/TrEMBL:Q7TZF1" FT /protein_id="CAD94598.1" FT /translation="MTVAPRRLAWTNARQSYPVRVAHVLSVNLARVRANPDPRAQSKLT FT GIDKVAASEAVMVRAPGSMHAGVGSGLVGDTVGNPKLHGGDDQAVYAYAREDLDAWETQ FT LHRTLHNGMFGENLTTSGVDVTYARIGERWRIGSDGLVLEVSAPRIPCRTFAAFLDLRY FT WIKTFTRAAKPGAYLRVIAPGTVRAGDTITVDYRPEHNVTVGLVFRARTSESELLPQLL FT AADALAAELKAYARERTPSPPPVDSADDV" FT CDS complement(188315..189175) FT /transl_table=11 FT /gene="Mb1896c" FT /locus_tag="Mb1896c" FT /product="PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE" FT /EC_number="1.-.-.-" FT /note="Mb1896c, -, len: 286 aa. Equivalent to Rv1865c, len: FT 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 286 aa overlap). Probable short-chain FT dehydrogenase (EC 1.-.-.-), highly similar to C-terminus of FT NP_301650.1|NC_00267 putative oxidoreductase from FT Mycobacterium leprae (596 aa). Also similar to various FT dehydrogenases, generally belonging to short-chain family, FT e.g. AAG02168.1|AF212041_24|AF212041 3-oxoacyl-(acylcarrier FT protein) reductase from Zymomonas mobilis (251 aa); FT P50198|LINX_PSEPA 2,5-DICHLORO-2,5-CYCLOHEXADIENE-1,4-DIOL FT DEHYDROGENASE from Sphingomonas paucimobilis (250 aa); FT NP_105680.1|NC_002678 sorbitol dehydrogenase (also similar FT to acetoin reductase) from Mesorhizobium loti (256 aa); FT etc. And highly similar to C-terminus of FT ephD|Rv2214c|MTCY190.25c from Mycobacterium tuberculosis FT (592 aa); and many other oxidoreductases from Mycobacterium FT tuberculosis e.g. Y00P_MYCTU|Q10402 putative oxidoreductase FT (650 aa), FASTA scores: opt: 439, E(): 8.9e-20, (32.5% FT identity in 280 aa overlap). Contains PS00061 Short-chain FT alcohol dehydrogenase family signature. BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7TZF0" FT /db_xref="HSSP:1FDW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZF0" FT /protein_id="CAD94599.1" FT /translation="MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKVA FT IGDIDEAMAKESGADLDLDMYGKLDVTDPDSFSGFLDAVERQLGPIDVLVNNAGIMPVG FT RIVDEPDPVTRRILDINVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVATYC FT ASKHAVVAFTDSARLEYRSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIV FT GLIVHPKPRVRVTKAAGSMIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEAR FT ARGEE" FT CDS 189349..191685 FT /transl_table=11 FT /gene="Mb1897" FT /locus_tag="Mb1897" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1897, -, len: 778 aa. Equivalent to Rv1866, len: FT 778 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 778 aa overlap). Conserved hypothetical FT protein, N-terminal region similar to fatty acyl-CoA FT racemases e.g. Rv0855, Rv1143, and C-terminal region (from FT aa 370) similar to L-carnitine dehydratases, racemases, and FT Rv3272|MTCY71.12 Mycobacterium tuberculosis (394 aa), FASTA FT score: opt: 472, E(): 2.1e-21, (29.9% identity in 388 aa FT overlap). Also similar to P31572|CAIB_ECOLI L-CARNITINE FT DEHYDRATASE (EC 4.2.1.89) (405 aa), FASTA score: opt: 306, FT E(): 2.1e-11, (23.3% identity in 424 aa overlap)." FT /db_xref="GOA:Q7TZE9" FT /db_xref="InterPro:IPR006311" FT /db_xref="UniProtKB/TrEMBL:Q7TZE9" FT /protein_id="CAD94600.1" FT /translation="MVTRLLADLGADVLKVQPPGGSPGRHVRPTLAGTSIGFAMHNANK FT RSAVLNPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVALSITD FT FGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATAAVQAAWAVLVAYF FT NRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGIRSTGRWRGRPKNQDAYPIYPCR FT DGYVRFCVMAPRQWRGLRRWLGEPEDFQDPKYDVIGARLAAWPQISVLVAKLCAEKTMK FT ELVAAGQALGVPITAVLTPSRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRA FT GFRTPAPAAGQDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDL FT GAEVIKVESADHPDGLRQTRVGDAMSESFAWTHRNHLALGLDLRNSEGKAIFGRLVAES FT DAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNRGPWSTRMGYGPLVRAATGV FT TRVWTSDEAQPDNSRHPFYDATTIFPDHVVGRVGALLALAALIHRDRTGGGAHVHISQA FT EVVVNQLDTMFVAEAARATDVAEIHPDTSVHAVYPCAGDDEWCVISIRSDDEWRRATSV FT FGQPELANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMNRPS FT DILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAPLPGQDSVQICRK FT LLGMTADETERLINERVMFGPAVTA" FT CDS 191973..193457 FT /transl_table=11 FT /gene="Mb1898" FT /locus_tag="Mb1898" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1898, -, len: 494 aa. Equivalent to Rv1867, len: FT 494 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 494 aa overlap). Conserved hypothetical FT protein, some similarity to acetyl CoA synthase and to FT lipid carriers. FASTA best: E155295 acetyl CoA synthase FT (388 aa), opt: 213, E(): 4.5e-07, (23.2% identity in 423 aa FT overlap)." FT /db_xref="GOA:Q7TZE8" FT /db_xref="UniProtKB/TrEMBL:Q7TZE8" FT /protein_id="CAD94601.1" FT /translation="MPVDPRTPVLIGYGQVNHRGDIDAEKQSIEPVDLMAAAARKAADS FT TVLEAVDSIRVVHMLSAHYRNPGQLLGERIKARTFTTGYSGVGGNMPQSLVNRACLDIQ FT RGRAGVVLLAGAETWRTRTGLRAKGSKLEWTVQDESVPLPDMAGDDVPMAGAAELRINL FT DRPAYVYPIFEQALRIAYGESIENHRKRIGELWARFSAVAADNPHAWIRNPVTADEIWQ FT PGPQNRMVSWPYTKLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTP FT AVADRHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGLDTDDP FT ARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITANGGYLTKHSFGVYGT FT EPPSEFRWEDMQPAVDREPTGDGLVEWEGIGTVEAWTTPVNRDGQPEKAFLAVRTPDGS FT RSLAVITDPASVQATVREDIAGVKVAVAPDGTATLR" FT CDS 193556..195655 FT /transl_table=11 FT /gene="Mb1899" FT /locus_tag="Mb1899" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1899, -, len: 699 aa. Equivalent to Rv1868, len: FT 699 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 699 aa overlap). Conserved hypothetical FT protein, similar to products of three consecutive ORFS in FT Mycobacterium leprae MLCB2052.18|Z98604|B2052 (257 aa), FT FASTA scores: opt: 314, E(): 9.9e-12, (35.2% identity in FT 213 aa overlap); MLCB2052.17, and MLCB2052.16. Also similar FT to M. tuberculosis hypothetical protein Rv2047c." FT /db_xref="GOA:Q7TZE7" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZE7" FT /protein_id="CAD94602.1" FT /translation="MQILVTDATGAVGRSVTRQLIAAGHTVSGIAQHPHDALDPRVDYV FT CASLRNPVLQELAGEADAVIHLAPVDTSAPGGVGITGLAHVANAAARAGARLLFVSQAA FT GRPELYRQAETLVSTGWAPSLVIRIAPPVGRQLDWMVCRTVATLLRSKVSARPIRVLHL FT DDLVRFLVLALNTDRNGVVDLATPDTTNVVTAWRLLRSVDPHLRTRRVRSWEQLIPEVD FT IAAVQEDWNFEFGWQATEAIVDTGRGLVGRRLHPAGATNGSGQLALPVEAPPRSVPSHG FT EPLGSAAPEGLEGEFDDRIDERFPVFSSASLAEALPGPLTPMTLDVQLSGLRAAGRAMG FT RVLALGGVVADEWERRAIAVFGHRPYIGVSANIVAAAQLPGWDAQAVARRALGEQPQVT FT ELLPFGRPQLAGGPLGSVAKVVVTARSLALLRHLRSDTHHYVAAADAEHLAAGQLASLP FT DAGLEVRIRLLRDRIHQGWILTVLWVIDTGVTAATLEHTRAGSAVSGGGMIMESGRIGA FT EIAPLAAVLRADPPLCALANDGNLASIRALSAPAAAAVDAVIARIGHRGLGEAELANLT FT FADDPALLLKTAAEIAARPAGPAHPATLIQRLAAGTRSARELAHDTTIRFTHELRMTLR FT ELGSRRVAADVIDVVDDVFYLTCDELITTPADARLRIKRRRAERERLQAQRPPDVIDHA FT WVPVE" FT CDS complement(195669..196904) FT /transl_table=11 FT /gene="Mb1900c" FT /locus_tag="Mb1900c" FT /product="Probable reductase" FT /EC_number="1.-.-.-" FT /note="Mb1900c, -, len: 411 aa. Equivalent to Rv1869c, len: FT 411 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 411 aa overlap). Probable reductase FT (1.-.-.-). Similar to several reductases e.g. FT CAC04223.1|AL391515 putative ferredoxin reductase from FT Streptomyces coelicolor (420 aa); THCD_RHOSO|P43494 FT rhodocoxin reductase (426 aa), FASTA scores: opt: 904, E(): FT 0, (40.8% identity in 370 aa overlap). Also similar to FT Mycobacterium tuberculosis proteins Rv0688 (406 aa) (39.9% FT identity in 391 aa overlap); and Rv0253 (nitrite reductase FT subunit)." FT /db_xref="GOA:Q7VET3" FT /db_xref="HSSP:1Q1W" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:Q7VET3" FT /protein_id="CAD94603.1" FT /translation="MASSTTFVIVGGGLAGAKAVEALRRSDFGGRIILFGDEEHLPYDR FT PPLSKEFLAGKKSLSDFTIQTSDWYRDHDVDVRLGVRVSSLDRSAHTVELPDGAAVRYD FT KLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGSSLAVVGAGWIGLEVAA FT SARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQLEEITAADGKAT FT GLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDI FT AAAEHPLLGTRVRTEHWANALKQPAVAAAGMLGRPGEYAELPYLFTDQYDLGMEYVGHA FT PSCDRVVFRGNVAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSGNPVDVDRLV FT DPQWPLADLTTN" FT CDS complement(196971..197639) FT /transl_table=11 FT /gene="Mb1901c" FT /locus_tag="Mb1901c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1901c, -, len: 222 aa. Equivalent to Rv1870c, len: FT 211 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 211 aa overlap). Conserved hypothetical FT protein. Some similarity to SC6F7.17c hypothetical protein FT from Streptomyces coelicolor (216 aa). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT single base transversion (t-a) and a single base transition FT (c-t) lead to a slightly longer product compared to the FT homolog in Mycobacterium tuberculosis strain H37Rv (222 aa FT versus 211 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7TZE6" FT /protein_id="CAD94604.1" FT /translation="MPPRIAGMRLLVIKPEPLARRLLKLAGTTYAAEAGIRIRDKPMPL FT FQLLVLCMLASKPIGAATAARAARELFCSGLRTPKAVLSAERQTMISAFGRAHYVRYDE FT SSATRLTAIAHRVRDEYSGDLRELAQRTRPDVSAAKRMLKTFNGIGDTGADIFLREVQD FT VWIWVRPYFDDRATAAAKQLGLPTDPKKLASVAPSSNALLAAALVRVALDDELRLQVTG FT " FT CDS complement(197704..198093) FT /transl_table=11 FT /gene="Mb1902c" FT /locus_tag="Mb1902c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1902c, -, len: 129 aa. Equivalent to Rv1871c, len: FT 129 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 129 aa overlap). Conserved hypothetical FT protein, similar to Mycobacterium tuberculosis hypothetical FT proteins Q11057|Rv1261|MTCY50.21 (149 aa), FASTA score: FT opt: 125, E(): 0.019, (32.6% identity in 89 aa overlap); FT Rv0523c, and Rv1598c." FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/TrEMBL:Q7TZE5" FT /protein_id="CAD94605.1" FT /translation="MNAAMNLKREFVHRVQRFVVNPIGRQLPMTMLETIGRKTGQPRRT FT AVGGRVVDNQFWMVSEHGEHSDYVYNIKANPAVRVRIGGRWRSGTAYLLPDDDPRQRLR FT GLPRLNSAGVRAMGTDLLTIRVDLD" FT CDS complement(198116..199360) FT /transl_table=11 FT /gene="lldD2" FT /locus_tag="Mb1903c" FT /product="POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) FT LLDD2" FT /EC_number="1.1.2.3" FT /note="Mb1903c, lldD2, len: 414 aa (start uncertain). FT Equivalent to Rv1872c, len: 414 aa, from Mycobacterium FT tuberculosis strain H37Rv, (99.5% identity in 414 aa FT overlap). Possible lldD2, L-lactate dehydrogenase FT (cytochrome) (EC 1.1.2.3), similar to other lactate FT dehydrogenases and other oxidases e.g. LLDD_ECOLI|P33232 FT l-lactate dehydrogenase (cytochrome) from Escherichia coli FT strain K12 (396 aa), FASTA results: opt: 674, E(): 1.1e-37, FT (40.5% identity in 279 aa overlap); Q51135 LACTATE FT DEHYDROGENASE from Neisseria meningitidis (390 aa), FASTA FT results: opt: 309, E(): 4.1e-15, (42.5% identity in 113 aa FT overlap); etc. Also shows similarity with FT Rv0694|lldD1|MTCY210.11 POSSIBLE L-LACTATE DEHYDROGENASE FT (CYTOCHROME) from Mycobacterium tuberculosis (396 aa). FT Contains PS00557 FMN-dependent alpha-hydroxy acid FT dehydrogenases active site. BELONGS TO THE FMN-DEPENDENT FT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q7TZE4" FT /db_xref="HSSP:1AL8" FT /db_xref="InterPro:IPR017934" FT /db_xref="UniProtKB/TrEMBL:Q7TZE4" FT /protein_id="CAD94606.1" FT /translation="MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAK FT RRTPRAAFDYADGAAEDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPTVLPF FT GIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQLYMW FT RDRDRSMALVRRAAAAGFDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHP FT RWWFDLLTTEPLAFASLDRWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQT FT LDDARAVVDRGVDGIVLSNHGGRQLDRAPVPFHLLPHVARELGKHTEILVDTGIMSGAD FT IVAAIALGARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPR FT HVTQLRRLGPIGAPT" FT CDS 199383..199820 FT /transl_table=11 FT /gene="Mb1904" FT /locus_tag="Mb1904" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1904, -, len: 145 aa. Equivalent to Rv1873, len: FT 145 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 145 aa overlap). Conserved hypothetical FT protein. Some similarity to AL591783 hypothetical protein FT from Sinorhizobium meliloti." FT /db_xref="InterPro:IPR014937" FT /db_xref="UniProtKB/TrEMBL:Q7TZE3" FT /protein_id="CAD94607.1" FT /translation="MKSASDPFDLKRFVYAQAPVYRSVVEELRAGRKRGHWMWFVFPQL FT RGLGSSPLAVRYGISSLEEAQAYLQHDLLGPRLHECTGLVNQVQGRSIEEIFGPPDNLK FT LCSSMTLFARATDANQDFVALLAKYYGGGEDRRTVALLAVT" FT CDS 199893..200579 FT /transl_table=11 FT /gene="Mb1905" FT /locus_tag="Mb1905" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1905, -, len: 228 aa. Equivalent to Rv1874, len: FT 228 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 228 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZE2" FT /protein_id="CAD94608.1" FT /translation="MLMRPEPDDDWCARQRAQVADALLGLGVAGLSINVRDSTVRDSLM FT TLTTLYPPVAAVVSLWTQQCYGEQVAAALRLLAQECDELGAYLVTESVPLTFPSLVESG FT SRTPGLANIALLRRPDGLDQATWLTRWQRDHTQVAIEAQATFGYTQNWVVRALTPEAPG FT IAGIVEELFPVAATTDLKAFFGAADDNDLRNRISRMVASTSAFGANQNIDTVPTSRYVF FT RTPFKD" FT CDS 200590..201033 FT /transl_table=11 FT /gene="Mb1906" FT /locus_tag="Mb1906" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1906, -, len: 147 aa. Equivalent to Rv1875, len: FT 147 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 147 aa overlap). Conserved hypothetical FT protein. Some similarity to Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 FT aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity FT in 130 aa overlap); Rv0121c and Rv2074. Also similar to FT AL079356|SC6G9.21 hypothetical protein from Streptomyces FT coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09, FT (38.7% identity in 137 aa overlap)." FT /db_xref="GOA:Q7TZE1" FT /db_xref="InterPro:IPR011576" FT /db_xref="UniProtKB/TrEMBL:Q7TZE1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94609.1" FT /translation="MTTLNEAAALAAAERGLAVVSTVRADGTVQASLVNVGLLPHPVSG FT EPSLGFTTYGKVKLGNLRARPQLAVTFRNGWQWATVEGRAQLVGPDDPRPWLVDGERLR FT LLLREVFTAAGGTHDDWDEYDRVMAQEQRAVVLITPTRIYSNG" FT CDS 201549..202028 FT /transl_table=11 FT /gene="bfrA" FT /locus_tag="Mb1907" FT /standard_name="bfr" FT /product="PROBABLE BACTERIOFERRITIN BFRA" FT /note="Mb1907, bfrA, len: 159 aa. Equivalent to Rv1876, FT len: 159 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 159 aa overlap). Probable bfrA, FT bacterioferritin, similar to BFR_MYCLE|P43315 FT bacterioferritin (bfr) from Mycobacterium leprae (159 aa), FT FASTA results: opt: 958, E(): 0, (90.6% identity in 159 aa FT overlap). Also similar to Rv3841|MTCY01A6.28c|bfrB POSSIBLE FT BACTERIOFERRITIN from Mycobacterium tuberculosis (181 aa). FT BELONGS TO THE BACTERIOFERRITIN FAMILY." FT /db_xref="GOA:P63698" FT /db_xref="HSSP:1BCF" FT /db_xref="InterPro:IPR012347" FT /db_xref="UniProtKB/Swiss-Prot:P63698" FT /protein_id="CAD94610.1" FT /translation="MQGDPDVLRLLNEQLTSELTAINQYFLHSKMQDNWGFTELAAHTR FT AESFDEMRHAEEITDRILLLDGLPNYQRIGSLRIGQTLREQFEADLAIEYDVLNRLKPG FT IVMCREKQDTTSAVLLEKIVADEEEHIDYLETQLELMDKLGEELYSAQCVSRPPT" FT CDS 202113..203648 FT /transl_table=11 FT /gene="Mb1908" FT /locus_tag="Mb1908" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN FT [FIRST PART]" FT /note="Mb1908, -, len: 511 aa. Similar to 5' end of Rv1877, FT len: 687 aa, from Mycobacterium tuberculosis strain H37Rv, FT (93.2% identity in 292 aa overlap). Probable conserved FT integral membrane protein, part of major facilitator FT superfamily (MFS), similar to many antibiotic and drug FT efflux proteins. Similar to e.g. Q56175 TU22 DTDP-GLUCOSE FT DEHYDRTATASE from Streptomyces violaceoruber (557 aa), FT FASTA scores: opt: 895, E(): 0, (34.7% identity in 528 aa FT overlap). Also similar to Mycobacterium tuberculosis FT relatives protein, include Rv3728, Rv3239c, Rv2846c, etc. FT Contains PS00217 Sugar transport proteins signature 2 FT (PS00217). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1877 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT insertion (*-c), splits Rv1877 into 2 parts, Mb1908 and FT Mb1909." FT /db_xref="GOA:Q7TZE0" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q7TZE0" FT /protein_id="CAD94611.1" FT /translation="MAGPTAPTTAPTAIRAGGPLLSPVRRNIIFTALVFGVLVAATGQT FT IVVPALPTIVAELGSTVDQSWAVTSYLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVV FT GSVLCGLSQTMTMLAISRALQGVGAGAISVTAYALAAEVVPLRDRGRYQGVLGAVFGVN FT TVTGPLLGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDYLGILVIA FT VATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGRARCGHPAAQAVWQPS FT ICRVLRPVLRGRIRDAGCTDLRTDLSGVRGRRVGDRVRSAHVADGDRPADRLDRDGCPG FT RPDGPLQDLPGRGDGADGGCVPADVADGRVDATAAAIAVPGRPRCRHRIVHAGARSHRA FT EHVVFRRPRRRNIGCDLLPGGRRLVWYRNIRCVVRKLPGPKTRFRADVGRRACPGSAIS FT GCLASAAPEHGRPDRAGICRVAHPGVPLRGLGHGGRFHPGAVAARGTAHRHPR" FT CDS 202963..204177 FT /transl_table=11 FT /gene="Mb1909" FT /locus_tag="Mb1909" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN FT [SECOND PART]" FT /note="Mb1909, -, len: 404 aa. Equivalent to 3' end of FT Rv1877, len: 687 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 404 aa overlap). Probable FT conserved integral membrane protein, part of major FT facilitator superfamily (MFS), similar to many antibiotic FT and drug efflux proteins. Similar to e.g. Q56175 TU22 FT DTDP-GLUCOSE DEHYDRTATASE from Streptomyces violaceoruber FT (557 aa), FASTA scores: opt: 895, E(): 0, (34.7% identity FT in 528 aa overlap). Also similar to Mycobacterium FT tuberculosis relatives protein, include Rv3728, Rv3239c, FT Rv2846c, etc. Contains PS00217 Sugar transport proteins FT signature 2 (PS00217). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base insertion (*-c), splits Rv1877 into 2 parts, FT Mb1908 and Mb1909." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q7TZD9" FT /protein_id="CAD94612.1" FT /translation="MCCVLSFVVGFAMLGALTFVPIYLGYVDGASATASGLRTLPMVIG FT LLIASTGTGVLVGRTGRYKIFPVAGMALMAVAFLLMSQMDEWTPPLLQSLYLVVLGAGI FT GLSMQVLVLIVQNTSSFEDLGVATSGVTFFRVVGASFGTATFGALFVNFLDRRLGSALT FT SGAVPVPAVPSPAVLHQLPQSMAAPIVRAYAESLTQVFLCAVSVTVVGFILALLLREVP FT LTDIHDDADDLGDGFGVPRAESPEDVLEIAVRRMLPNGVRLRDIATQPGCGLGVAELWA FT LLRIYQYQRLFEAVRLTDIGRHLHVPYQVFEPVFDRLVQTGYAARDGDILTLTPSGHRQ FT VDSLAVLIRQWLLDHLAVAPGLKRQPDHQFEAALQHVTDAVLVQRDWYEDLGDLSESRQ FT LAATT" FT CDS 204232..205584 FT /transl_table=11 FT /gene="glnA3" FT /locus_tag="Mb1910" FT /product="PROBABLE GLUTAMINE SYNTHETASE GLNA3 (GLUTAMINE FT SYNTHASE) (GS-I)" FT /EC_number="6.3.1.2" FT /note="Mb1910, glnA3, len: 450 aa. Equivalent to Rv1878, FT len: 450 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 450 aa overlap). Probable glnA3, FT glutamine synthetase class I (EC 6.3.1.2), similar to many FT e.g. GLNA_BACCE|P19064 from Bacillus cereus (443 aa), FASTA FT results: opt: 497, E(): 5.2e-23, (29.0% identity in 331 aa FT overlap); etc. Also similar to C-terminus of FT FLUG_EMENI|P38094 flug protein from emericella nidulans FT (865 aa), FASTA scores: opt: 227, E (): 6.4e-13, (29.9% FT identity in 394 aa overlap). Note that the downstream ORF FT MTCY180.39c is similar to the N-terminus. Also similar to FT three other potential glutamine synthases in M. FT tuberculosis: FT Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY427. FT 03c; Rv2860c|MTV003.06c|glnA4 and Rv2220|glnA1. BELONGS TO FT THE GLUTAMINE SYNTHETASE FAMILY." FT /db_xref="GOA:Q7TZD8" FT /db_xref="InterPro:IPR008146" FT /db_xref="UniProtKB/TrEMBL:Q7TZD8" FT /protein_id="CAD94613.1" FT /translation="MTATPLAAAAIAQLEAEGVDTVIGTVVNPAGLTQAKTVPIRRTNT FT FANPGLGASPVWHTFCIDQCSIAFTADISVVGDQRLRIDLSALRIIGDGLAWAPAGFFE FT QDGTPVPACSRGTLSRIEAALADAGIDAVIGHEVEFLLVDADGQRLPSTLWAQYGVAGV FT LEHEAFVRDVNAAATAAGIAIEQFHPEYGANQFEISLAPQPPVAAADQLVLTRLIIGRT FT ARRHGLRVSLSPAPFAGSIGSGAHQHFSLTMSEGMLFSGGTGAAGMTSAGEATVAGVLR FT GLPDAQGILCGSIVSGLRMRPGNWAGIYACWGTENREAAVRFVKGGAGSAYGGNVEVKV FT VDPSANPYLASAAILGLALDGMKTKAVLPSETTVDPTQLSDVDRDRAGILRLAADQADA FT IAVLDSSKLLRCILGDPVVDAVVAVRQLEHERYGDLDPAQLADKFRMAWSV" FT CDS 205587..206723 FT /transl_table=11 FT /gene="Mb1911" FT /locus_tag="Mb1911" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1911, -, len: 378 aa. Equivalent to Rv1879, len: FT 378 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 378 aa overlap). Conserved hypothetical FT protein, similar to SCC22.14c|AL096839 hypothetical protein FT from Streptomyces coelicolor (368 aa), FASTA results: opt: FT 772, E(): 0 (40.3% identity in 372 aa overlap); and to FT N-terminal half of nodulin/glutamate-ammonia ligase-like FT protein. Some similarity to N-terminus of FT AL132958|ATT4D2_11 Arabidopsis thaliana (845 aa), FASTA FT results: opt: 354, E(): 3.1e-16, (29.2% identity in 383 aa FT overlap); and to P38094|FLUG_EMENI Flug protein of FT Emericella nidulans (865 aa), FASTA results: opt: 306, E(): FT 6.2e-13, (26.5% identity in 415 aa overlap). Note that the FT upstream ORF Rv1878|MTCY18 0.40c is similar to the FT C-terminus." FT /db_xref="GOA:Q7TZD7" FT /db_xref="InterPro:IPR006992" FT /db_xref="UniProtKB/TrEMBL:Q7TZD7" FT /protein_id="CAD94614.1" FT /translation="MADSAGSDLTRHTAEVPLIDQHVHGCWLTEGNRRRFENALNEANT FT EPLADFDSGFDSQLGFAVRNHCAPILGLPRHVDPQTYWDRRSQFSEAELARRFLQAAGV FT TDWLVETGIGYDVSGMASVAGLGELSGSHAHEVVRLEQVAEQAVQASGDYASAFNEILR FT RRAATAVATKSILAYRGGFDGDLTEPPAAQVAEAAKRWRDRGGVRLQDRVLLRFGLHQA FT LRLGKPLQFHVGFGDRDADLHKANPLYLLDFLRQSGNTPIVLLHCYPYEREAGYLAQAF FT NNVYLDGGLSVHYLGARSPAFIGRLLELAPFRKIVYSSDGFGPAELHFLGATLWRSGIQ FT RVLRGFVERDDWCETDALRVVDLIAHGTAARIYRLGDR" FT CDS complement(206751..208067) FT /transl_table=11 FT /gene="cyp140" FT /locus_tag="Mb1912c" FT /product="Probable cytochrome p450 140 CYP140" FT /EC_number="1.14.-.-" FT /note="Mb1912c, cyp140, len: 438 aa. Equivalent to Rv1880c, FT len: 438 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 438 aa overlap). Probable cyp140, FT cytochrome p450 (EC 1.14.-.-). Similar to Q00441|CPXJ_SACER FT 6-deoxyerythronolide beta hydroxylase (404 aa), FASTA FT scores: opt: 775, E(): 0, (44.2% identity in 319 aa FT overlap); and other members of the cytochrome P450 family. FT Related to Mycobacterium tuberculosis proteins include: FT Rv0766c, Rv2266, Rv0778, etc. Contains cytochrome P450 FT cysteine heme-iron ligand signature (PS00086). BELONGS TO FT THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P63722" FT /db_xref="HSSP:1OXA" FT /db_xref="InterPro:IPR017972" FT /db_xref="UniProtKB/Swiss-Prot:P63722" FT /protein_id="CAD94615.1" FT /translation="MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPFY FT DEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQLH FT PLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIVDVV FT GRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRGFDCW FT LEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGN FT GIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVRIKRGEV FT VVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGEVGLRTFF FT DRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP" FT CDS complement(208117..208539) FT /transl_table=11 FT /gene="lppE" FT /locus_tag="Mb1913c" FT /product="POSSIBLE CONSERVED LIPOPROTEIN LPPE" FT /note="Mb1913c, lppE, len: 140 aa. Equivalent to Rv1881c, FT len: 140 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 140 aa overlap=. Possible lppE, FT lipoprotein, showing some similarity to L12238|MSG18S19K_1 FT 19K antigen from Mycobacterium intracellulare (162 aa), FT FASTA scores: opt: 137, E(): 0.0069, (27.6% identity in 156 FT aa overlap). Contains signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="UniProtKB/TrEMBL:Q7TZD6" FT /protein_id="CAD94616.1" FT /translation="MCNRLVTVTGVAMVVAAGLSACGQAQTVPRKAARLTIDGVTHTTR FT PATCSQEHSYRTIDIRNHDSTVQAVVLLSGDRVIPQWVKIRNVDGFNGSFWHGGVGNAR FT ADRARNTYTVAGSAYGISSKKPNTVVSTDFNILAEC" FT CDS complement(208580..209413) FT /transl_table=11 FT /gene="Mb1914c" FT /locus_tag="Mb1914c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.1.-.-" FT /note="Mb1914c, -, len: 277 aa. Equivalent to Rv1882c, len: FT 277 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 277 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT dehydrogenases/reductases, generally belonging to SDR FT family, e.g. NP_250789.1|NC_002516 probable short-chain FT dehydrogenase from Pseudomonas aeruginosa (251 aa); FT NP_421760.1|NC_002696 short chain dehydrogenase family FT protein from Caulobacter crescentus (270 aa); FT NP_107167.1|NC_002678 oxidoreductase (short chain FT dehydrogenase/reductase family) from Mesorhizobium loti FT (253 aa); P50197|LINC_PSEPA FT 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from FT Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 FT aa), FASTA scores: opt: 301, E(): 2.3e-12, (30.0% identity FT in 223 aa overlap); etc. Also similar to proteins from FT Mycobacterium tuberculosis e.g. Rv3057c, Rv1245, etc. FT Contains possible helix-turn-helix motif at aa 246-267 FT (+4.32 SD). Contains PS00061 Short-chain alcohol FT dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7TZD5" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZD5" FT /protein_id="CAD94617.1" FT /translation="MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALRVQL FT GAERLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIGEGGWFEDVPYEAAVR FT VVDVNFKAVLTGAYAALPYLKKAPGSLMFSTSSSSGTYGMPRIAVYSATKHAVKGLTEA FT LSVEWQRHGVRVADVLPGLIDTAILTSTRQHSDEGPYTISAEQIRAAAPKKGMFRLMPS FT SSVAEAAWRAYQHPTRLHWYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK" FT CDS complement(209441..209917) FT /transl_table=11 FT /gene="Mb1915c" FT /locus_tag="Mb1915c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1915c, -, len: 158 aa. Equivalent to Rv1883c, len: FT 153 aa, from Mycobacterium tuberculosis strain H37Rv, FT (96.8% identity in 158 aa overlap). Conserved hypothetical FT protein, some similarity to hypothetical proteins e.g. FT Rv2778c|AL008967|MTV002.43 from Mycobacterium tuberculosis FT (156 aa), FASTA score: opt: 212, E(): 3.1e-08, (34.4% FT identity in 151 aa overlap). Also similar to FT U75434|SAU75434_3 Nsh-OrfB from Streptomyces actuosus (173 FT aa), FASTA score: opt: 207, E(): 1.8e-07, (40.2% identity FT in 102 aa overlap). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a 15 bp in-frame insertion leads to a FT longer product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (158 aa versus 153 aa)." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/TrEMBL:Q7TZD4" FT /protein_id="CAD94618.1" FT /translation="MCLDQVMEGSATVHMAAPPDKIWTLIADVRNTGRFSPETFEAEWL FT DGATGPALGARFRGHVRRNGIGPVYWTVCEVTACEPGREFGFAVLLGDRPVNNWHYRLT FT PTADGTEVTESFRLPPSVLTTVYYRVFGGWLRQRRNIRDMTKTLQRIKDLVEAG" FT CDS complement(209956..210486) FT /transl_table=11 FT /gene="rpfC" FT /locus_tag="Mb1916c" FT /product="PROBABLE RESUSCITATION-PROMOTING FACTOR RPFC" FT /note="Mb1916c, rpfC, len: 176 aa. Equivalent to Rv1884c, FT len: 176 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 176 aa overlap). Probable rpfC, FT resuscitation promoting factor (see citation below), FT similar to Z96935|MLRPF_1 resusicitation-promoting factor FT from Micrococcus luteus (220 aa), FASTA score: opt: 287, FT E() : 3.3e-11, (40.0% identity in 120 aa overlap). Also FT similar to others from Mycobacterium tuberculosis: FT Rv2389c|MTCY253.32|RPFD PROBABLE RESUSCITATION-PROMOTING FT FACTOR (154 aa), FASTA score: opt: 382, E(): 7.1e-17, FT (55.4% identity in 101 aa overlap); Rv0867c|RPFA FT (N-terminal part), Rv2450c|RPFE, and Rv1009|RPFB FT (C-terminal part)." FT /db_xref="GOA:Q7TZD3" FT /db_xref="InterPro:IPR010618" FT /db_xref="UniProtKB/TrEMBL:Q7TZD3" FT /protein_id="CAD94619.1" FT /translation="MHPLPADHGRSRCNRHPISPLSLIGNASATSGDMSSMTRIAKPLI FT KSAMAAGLVTASMSLSTAVAHAGPSPNWDAVAQCESGGNWAANTGNGKYGGLQFKPATW FT AAFGGVGNPAAASREQQIAVANRVLAEQGLDAWPTCGAASGLPIALWSKPAQGIKQIIN FT EIIWAGIQASIPR" FT CDS complement(210498..211097) FT /transl_table=11 FT /gene="Mb1917c" FT /locus_tag="Mb1917c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1917c, -, len: 199 aa. Equivalent to Rv1885c, len: FT 199 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 199 aa overlap). Conserved hypothetical FT protein, some similarity to P42517|CHMU_ERWHE FT MONOFUNCTIONAL CHORISMATE MUTASE (181 aa), FASTA score: FT opt: 181, E(): 0.00017, (28.6% identity in 133 aa FT overlap)." FT /db_xref="GOA:Q7TZD2" FT /db_xref="InterPro:IPR002701" FT /db_xref="UniProtKB/TrEMBL:Q7TZD2" FT /protein_id="CAD94620.1" FT /translation="MLTRPREIYLATAVSIGILLSLIAPLGPPLARADGTSQLAELVDA FT AAERLEVADPVAAFKWRAQLPIEDSGRVEQQLAKLGEDARSQHIDPDYVTRVFDDQIRA FT TEAIEYSRFSDWKLNPASAPPEPPDLSASRSAIDSLNNRMLSQIWSHWSLLSAPSCAAQ FT LDRAKRDIVRSRHLDSLYQRALTTATQSYCQALPPA" FT CDS complement(211115..212092) FT /transl_table=11 FT /gene="fbpB" FT /locus_tag="Mb1918c" FT /standard_name="mpt59; 85B" FT /product="secreted antigen 85-B fbpB (85B) (antigen 85 FT complex B) (Mycolyl transferase 85B) (Fibronectin-binding FT protein B) (Extracellular alpha-antigen)" FT /EC_number="2.3.1.-" FT /note="Mb1918c, fbpB, len: 325 aa. Equivalent to Rv1886c, FT len: 325 aa, from Mycobacterium tuberculosis strain H37Rv FT (100.0% identity in 325 aa overlap). fbpB (alternate gene FT names: mpt59, 85B), precursor of the 85-B antigen FT (fibronectin-binding protein B) (mycolyl transferase 85B) FT (EC 2.3.1.-) (see citations below), highly similar to other FT Mycobacterial antigen precursors e.g. P12942|A85B_MYCBO FT ANTIGEN 85-B PRECURSOR from Mycobacterium bovis (323 aa); FT P21160|A85B_MYCKA ANTIGEN 85-B PRECURSOR from Mycobacterium FT kansasii (325 aa); etc. Also highly similar to FT Mycobacterium tuberculosis antigen precursors: Rv3804c|fbpA FT (338 aa), Rv0129c|fbpC2 (340 aa), and Rv3803c|fbpC1 (299 FT aa)." FT /db_xref="GOA:P0C2T2" FT /db_xref="HSSP:1F0N" FT /db_xref="InterPro:IPR000801" FT /db_xref="UniProtKB/Swiss-Prot:P0C2T2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94621.1" FT /translation="MTDVSRKIRAWGRRLMIGTAAAVVLPGLVGLAGGAATAGAFSRPG FT LPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQS FT GLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAI FT GLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGP FT SSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQ FT DAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG" FT CDS 212483..213625 FT /transl_table=11 FT /gene="Mb1919" FT /locus_tag="Mb1919" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1919, -, len: 380 aa. Equivalent to Rv1887, len: FT 380 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 380 aa overlap). Hypothetical unknown FT protein; contains eukaryotic thiol (cysteine) proteases FT histidine active site at N-terminus (PS00639) and Pro-rich FT region near C-terminus." FT /db_xref="InterPro:IPR000169" FT /db_xref="UniProtKB/TrEMBL:Q7TZD1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94622.1" FT /translation="MDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQAI FT HTAEQLAAEVLLAHEVAAAGDHRLRVIGVTWNAEASAQAALLVESLTGAGFDNVVPVRR FT LRAIETLAQAIAPVIGYEQIAVCVLEHESATVVMVDTHDGKTQIAVKHVCRGLSGLTSW FT LTGMFGRDAWRPAGVVVVGSDSEVSEFSWQLERVLPVPVFAQTMAQVTVARGAALAAAQ FT STEFTDAQLVADSVSQPTVAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLAPHNDT FT GTAKHGAHKPTPRIAKAVAPAVPPPPTVTPPVPARAPRPAAQHEPPARVTSGEALTEPN FT PPEEQPNASAPQQDRNDSQPITRVLEHIPGAYGDSAPPAE" FT CDS complement(213595..214314) FT /transl_table=11 FT /gene="Mb1920c" FT /locus_tag="Mb1920c" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /note="Mb1920c, -, len: 239 aa. Similar to Rv1888c, len: FT 186 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 186 aa overlap). Possible transmembrane FT protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a 10 bp insertion (*-tccgatcacc) leads to a longer FT product with a different COOH part compared to its homolog FT in Mycobacterium tuberculosis H37Rv (239 aa versus 186 FT aa)." FT /db_xref="GOA:Q7TZD0" FT /db_xref="UniProtKB/TrEMBL:Q7TZD0" FT /protein_id="CAD94623.1" FT /translation="MQPDAYPVRVRGDLDPALSRWQWLVKWFLAIPHYIVLFFLHVAAV FT VVTVIAFFAILFTGRYPRTLFDFNVGVMRWRWRVAFYALSALGTDRYPPFSLQTKAEYP FT ADLEVDYPERLSRGLVLIKWWLLAIPHYLILAVFLSSGWRVFLIDPHDRVGIMWPSLLV FT ILLLVAVVALLFTGRYPIGLYNLVIGVNRWALRVRAYTTLMRDEYPPLRLDMGPREQVS FT QPATAASDYSAGGAESP" FT CDS complement(214679..214852) FT /transl_table=11 FT /gene="Mb1921c" FT /locus_tag="Mb1921c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1921c, -, len: 57 aa. Equivalent to Rv1888A, len: FT 57 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 57 aa overlap). Conserved hypothetical FT protein. Possibly continuation of Rv1889c, part of large FT family of Mycobacterium tuberculosis proteins with FT conserved N-terminal domain of ~ 120 aa. Includes: FT C-terminus of Rv0726c|P95074 CONSERVED HYPOTHETICAL PROTEIN FT (367 aa), FASTA scores: opt: 295, E(): 3.1e-15, (73.684% FT identity in 57 aa overlap); C-terminus of FT Rv3399|Q50726|MTCY78.29c CONSERVED HYPOTHETICAL PROTEIN FT (348 aa), FASTA scores: opt: 504, E(): 7.3e-29, (64.2% FT identity in 120 aa overlap); C-terminus of Rv0731c; etc." FT /db_xref="UniProtKB/TrEMBL:Q7TZC9" FT /protein_id="CAD94624.1" FT /translation="MVPVDLRRDWPTPLRQAGFDPNQPSAWLAEGLLAFLPPDAQDRLL FT DNITALSAPGSR" FT CDS complement(214896..215252) FT /transl_table=11 FT /gene="Mb1922c" FT /locus_tag="Mb1922c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1922c, -, len: 118 aa. Equivalent to Rv1889c, len: FT 118 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 118 aa overlap). Conserved hypothetical FT protein. Part of large family of Mycobacterium tuberculosis FT proteins with conserved N-terminal domain of ~ 120 aa. FT Includes: Rv3399|Q50726|MTCY78.29C hypothetical 38.1 kd FT protein (348 aa), FASTA results: opt: 504, E(): 7.3e-29, FT (64.2% identity in 120 aa overlap); Rv0726c, Rv0731c, etc." FT /db_xref="GOA:Q7TZC8" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/TrEMBL:Q7TZC8" FT /protein_id="CAD94625.1" FT /translation="MPRTNNDAWDLATSVGATATMVAAARAVATRADNPLIDDPFAEPL FT VRAVGIDFFTRWAAGNIKATDVDDPDGTWGLQRLADLLAARTRYFDAFFRDATSAGIRQ FT AVILASGLDARAYR" FT CDS complement(215311..215922) FT /transl_table=11 FT /gene="Mb1923c" FT /locus_tag="Mb1923c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1923c, -, len: 203 aa. Equivalent to Rv1890c, len: FT 203 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 203 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR007372" FT /db_xref="UniProtKB/TrEMBL:Q7TZC7" FT /protein_id="CAD94626.1" FT /translation="MAHKTRREGRAGRSSEYSRGVSDAVWTLDASDGELVLRTGVVGRA FT ARLGHRLTIAMTRWQALVNWSGTDPVAGELVAEVDSFEVMRGEGGVKGLSEPEKALVRA FT NALKTLNASRFPHIRFTTEAIAQTGNGYRLTGKLHIRGKSREHVIDLHTEDLGAAWRIS FT ADTTVRQSNYGVKPYSLLMGSIRVADEVSVAFTAVRAKDD" FT CDS 215976..216383 FT /transl_table=11 FT /gene="Mb1924" FT /locus_tag="Mb1924" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1924, -, len: 135 aa. Equivalent to Rv1891, len: FT 135 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 135 aa overlap). Conserved hypothetical FT protein. Equivalent to MLCB561.09|AL049571 hypothetical FT protein from Mycobacterium leprae (134 aa), FASTA scores: FT opt: 800, E(): 0, (79.7% identity in 133 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZC6" FT /protein_id="CAD94627.1" FT /translation="MIRELVTTAAITGAAIGGAPVAGADPQRYDGDVPGMNYDASLGAP FT CSSWERFIFGRGPSGQAEACHFPPPNQFPPAETGYWVISYPLYGVQQVGAPCPKPQAAA FT QSPDGLPMLCLGARGWQPGWFTGAGFFPPEP" FT CDS 216400..216711 FT /transl_table=11 FT /gene="Mb1925" FT /locus_tag="Mb1925" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb1925, -, len: 103 aa. Equivalent to Rv1892, len: FT 103 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 103 aa overlap). Probable membrane FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZC5" FT /protein_id="CAD94628.1" FT /translation="MIMCEGRPTESPIPRWLRFVLTSDRAGSAWYIGAGFFFAPVLAVL FT SPWPTITAVLWWIIGLAGLWLGLLGIAMAVGLARVLRSGAEIPEAYWRTLVDYRSANE" FT CDS 216721..216939 FT /transl_table=11 FT /gene="Mb1926" FT /locus_tag="Mb1926" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1926, -, len: 72 aa. Equivalent to Rv1893, len: 72 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 72 aa overlap). Conserved hypothetical protein. FT Equivalent to MLCB561.11|AL049571 hypothetical protein from FT Mycobacterium leprae (74 aa), FASTA scores: opt: 317, E(): FT 4.6e-15, (69.4% identity in 72 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7TZC4" FT /protein_id="CAD94629.1" FT /translation="MSFNPKDAVDAVRDIAANAVEKASDIVENAGHIIRGDIAGGASGI FT VKDSIDIATHAVDRTKEVFTGKTDDEG" FT CDS complement(216974..218104) FT /transl_table=11 FT /gene="Mb1927c" FT /locus_tag="Mb1927c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1927c, -, len: 376 aa. Equivalent to Rv1894c, len: FT 376 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 376 aa overlap). Conserved hypothetical FT protein, weak similarity to some oxidoreductases e.g. FT Q01284 2-NITROPROPANE DIOXYGENASE PRECURSOR (378 aa), FASTA FT results: opt: 204, E(): 5.8e-06, (34.3% identity in 140 aa FT overlap). Similar to hypothetical Mycobacterium FT tuberculosis proteins e.g. Rv3553|MTCY03C7.02c (355 aa), FT FASTA results: opt: 296, E(): 1.6e-10, (32.9% identity in FT 167 aa overlap); Rv1533 (375 aa) (48.1% identity in 376 aa FT overlap); Rv0021c, Rv2781c." FT /db_xref="GOA:Q7TZC3" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:Q7TZC3" FT /protein_id="CAD94630.1" FT /translation="MHTAICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFTPE FT QLEIELNWIDEHIGDHPYGVDIVIPNKYEGMDSQLSADELAKTLRSMVPQEHLDFARKI FT LADHGVPVEDADEDSLQLLGWTEATATPQVDAALKHPKMTMVANALGTPPADMIKHIHD FT SGRKVAALCGSPSQARKHADAGVDIIIAQGGEAGGHCGEVGSIVLWPQVVKEVAPVPVL FT AAGGIGSGQQIAAALALGTQGAWTGSQWLMVEEAANTAVQQAAYVKATSRDTVRSRSFT FT GKPARMLRNDWTEAWEQPESPKPLGMPLQYMVSGMAVKATHKYPNETVDVAFNPVGQVV FT GQFTKVEKTATVIERWVQEYLEATARLDALNAAASV" FT CDS 218756..219079 FT /transl_table=11 FT /gene="Mb1928" FT /locus_tag="Mb1928" FT /product="POSSIBLE DEHYDROGENASE [FIRST PART]" FT /EC_number="1.1.-.-" FT /note="Mb1928, -, len: 107 aa. Equivalent to 5' end of FT Rv1895, len: 384 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 96 aa overlap). Possible FT dehydrogenase (EC 1.1.-.-), similar to various sorbitol and FT alcohol dehydrogenases, and to putative FT glutathione-dependent aldehyde dehydrogenase e.g FT DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14) from FT Streptomyces coelicolor (352 aa), FASTA results: opt: 506, FT E(): 7.2e-24, (30.6% identity in 350 aa overlap); and FT AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE FT from Streptomyces coelicolor (356 aa), FASTA results: opt: FT 634, E(): 2.9e-30, (34.7% identity in 357 aa overlap). Also FT similar to other Mycobacterium tuberculosis dehydrogenases. FT Note that there is a substantial (134 bp) overlap at the FT C-terminus with the C-terminus of the downstream ORF, FT although both appear to be true coding regions. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1895 exists as a single gene. FT In Mycobacterium bovis, two frameshifts due to a single FT base deletion (a-*) and a single base insertion (*-t), FT consecutively, splits Rv1895 into 2 main parts, Mb1928 and FT Mb1929." FT /db_xref="GOA:Q7TZC2" FT /db_xref="HSSP:1PL7" FT /db_xref="InterPro:IPR013154" FT /db_xref="UniProtKB/TrEMBL:Q7TZC2" FT /protein_id="CAD94631.1" FT /translation="MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFY FT EGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGCEPMIQSCAS FT PAR" FT CDS 219076..219780 FT /transl_table=11 FT /gene="Mb1929" FT /locus_tag="Mb1929" FT /product="POSSIBLE DEHYDROGENASE [SECOND PART]" FT /EC_number="1.1.-.-" FT /note="Mb1929, -, len: 234 aa. Equivalent to middle part of FT Rv1895, len: 384 aa, from Mycobacterium tuberculosis strain FT H37Rv, (97.9% identity in 234 aa overlap). Possible FT dehydrogenase (EC 1.1.-.-), similar to various sorbitol and FT alcohol dehydrogenases, and to putative FT glutathione-dependent aldehyde dehydrogenase e.g FT DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14) from FT Streptomyces coelicolor (352 aa), FASTA results: opt: 506, FT E(): 7.2e-24, (30.6% identity in 350 aa overlap); and FT AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE FT from Streptomyces coelicolor (356 aa), FASTA results: opt: FT 634, E(): 2.9e-30, (34.7% identity in 357 aa overlap). Also FT similar to other Mycobacterium tuberculosis dehydrogenases. FT ****Note that there is a substantial (134 bp) overlap at FT the C-terminus with the C-terminus of the downstream ORF, FT although both appear to be true coding regions. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1895 exists as a single gene. FT In Mycobacterium bovis, two frameshifts due to a single FT base deletion (a-*) and a single base insertion (*-t), FT consecutively, splits Rv1895 into 2 main parts, Mb1928 and FT Mb1929." FT /db_xref="GOA:Q7TZC1" FT /db_xref="HSSP:1BXZ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZC1" FT /protein_id="CAD94632.1" FT /translation="MIFGAGVLGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLA FT TGWAAAQRADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGA FT TPIPSPAAETILAATRGRGADSVIDAVGTDASMSDALNAVRPGGTVSVVGVHDLQPFPL FT PALTCLLRSITLRMTMAPVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEAAKGYATARA FT RSGEELKVLLTP" FT CDS complement(219770..220681) FT /transl_table=11 FT /gene="Mb1931c" FT /locus_tag="Mb1931c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1931c, -, len: 303 aa. Equivalent to Rv1896c, len: FT 303 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 303 aa overlap). Conserved hypothetical FT protein. Similar to several (14) hypothetical Mycobacterium FT tuberculosis proteins e.g. Rv0145|MTCI5.19 (317 aa), FASTA FT results: opt: 720, E(): 0, (41.6% identity in 308 aa FT overlap); Q10552|YZ21_MYCTU (325 aa), opt: 689, E(): 0, FT (40.5% identity in 304 aa overlap); Rv0726c, Rv0731c, FT Rv3399, etc. and to related proteins in other FT actinomycetes. Note that there is a substantial (134 bp) FT overlap at the C-terminus with the C-terminus of the FT downstream ORF, although both appear to be true coding FT regions." FT /db_xref="GOA:Q7TZC0" FT /db_xref="InterPro:IPR011610" FT /db_xref="UniProtKB/Swiss-Prot:Q7TZC0" FT /protein_id="CAD94633.1" FT /translation="MTTPEYGSLRSDDDHWDIVSNVGYTALLVAGWRALHTTGPKPLVQ FT DEYAKHFITASADPYLEGLLANPRTSEDGTAFPRLYGVQTRFFDDFFNCADEAGIRQAV FT IVAAGLDCRAYRLDWQPGTTVFEIDVPKVLEFKARVLSERGAVPKAHRVAVPADLRTDW FT PTPLTAAGFDPQRPSAWSVEGLLPYLTGDAQYALFARIDELCAPGSRVALGALGSRLDH FT EQLAALETAHPGVNMSGDVNFSALTYDDKTDPVEWLVEHGWAVDPVRSTLELQVGYGLT FT PPDVDVKIDSFMRSQYITAVRA" FT CDS complement(220686..221117) FT /transl_table=11 FT /gene="Mb1932c" FT /locus_tag="Mb1932c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1932c, -, len: 143 aa. Equivalent to Rv1897c, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 143 aa overlap). Conserved hypothetical FT protein. Some similarity to D63706|Q54235 ORF2 from FT Streptomyces griseus (149 aa), FASTA results: opt: 509, FT E(): 1.2e-28, (57.3% identity in 150 aa overlap); and FT Q45303 ORF1 PROTEIN from Corynebacterium glutamicum (144 FT aa), FASTA results: opt: 460, E(): 5.5e-23, (49.7% identity FT in 143 aa overlap)." FT /db_xref="GOA:P63996" FT /db_xref="HSSP:1JKE" FT /db_xref="InterPro:IPR003732" FT /db_xref="UniProtKB/Swiss-Prot:P63996" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94634.1" FT /translation="MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKA FT RRLAEKLWNLRVLADEKSASDMHAPILVISQFTLYADTAKGRRPSWNAAAPGAVAQPLI FT AAFAAALRQLGAHVEAGVFGAHMQVELVNDGPVTVMLEG" FT CDS 221175..221483 FT /transl_table=11 FT /gene="Mb1933" FT /locus_tag="Mb1933" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1933, -, len: 102 aa. Equivalent to Rv1898, len: FT 102 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 102 aa overlap). Conserved hypothetical FT protein, some similarity to other hypothetical proteins FT e.g. Q58452 from METHANOCOCCUS JANNASCH II (100 aa), FASTA FT results: opt: 152, E(): 9.1e-05, (31.5% identity in 92 aa FT overlap); and AE000771|AE000771_2 from Aquifex aeolicus FT (157 aa), FASTA results: opt: 246, E(): 3.2e-11, (39.0% FT identity in 100 aa overlap)." FT /db_xref="InterPro:IPR002767" FT /db_xref="UniProtKB/Swiss-Prot:P67120" FT /protein_id="CAD94635.1" FT /translation="MSVLVAFSVTPLGVGEGVGEIVTEAIRVVRDSGLPNQTDAMFTVI FT EGDTWAEVMAVVQRAVEAVAARAPRVSAVIKVDWRPGVTDAMTQKVATVERYLLRPE" FT CDS complement(221449..222525) FT /transl_table=11 FT /gene="lppD" FT /locus_tag="Mb1934c" FT /product="POSSIBLE LIPOPROTEIN LPPD" FT /note="Mb1934c, lppD, len: 358 aa. Similar to Rv1899c, len: FT 343 aa, from Mycobacterium tuberculosis strain H37Rv, FT (95.5% identity in 358 aa overlap). Possible lipoprotein; FT contains appropriately localized lipoprotein lipid FT attachment site (PS00013). Some similarity to C-terminal FT part of AE000717|AE000717_4 hypothetical protein from FT Aquifex aeolicus section 49 (165 aa), FASTA results: opt: FT 372, E(): 2.3e-14, (43.5% identity in 147 aa overlap); and FT Q44020 4-hydroxybutyrate dehydrogenase (173 aa), FASTA FT results: opt: 272, E(): 4.7e-09, (35.8% identity in 165 aa FT overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a 45 bp in-frame insertion leads to a longer product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (358 aa versus 343 aa)." FT /db_xref="HSSP:1VHU" FT /db_xref="InterPro:IPR002589" FT /db_xref="UniProtKB/Swiss-Prot:Q7TZB9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94636.1" FT /translation="MSRAAGLPRLSWFAGLTWFAGGSTGAGCAAHPALAGLTAGARCPA FT YAAISASTARPAATALPAVAASTARPAATAGTTPATGASGSARPTDAAGMADLARPGVV FT ATHAVRTLGTTGSRAIGLCPCQPLDCPRSPQATPNLGSMGRSLDGPQWRRARVRLCGRW FT WRRSNTTRGASPRPPSTCRGDNVSMIELEVHQADVTKLELDAITNAANTRLRHAGGVAA FT AIARAGGPELQRESTEKAPIGLGEAVETTAGDMPARYVIHAATMELGGPTSGEIITAAT FT AATLRKADELGCRSLALVAFGTGVGGFPLDDAARLMVGAVRRHRPGSLQRVVFAVHGDA FT AERAFSAAIQAGEDTARR" FT CDS complement(222525..223913) FT /transl_table=11 FT /gene="lipJ" FT /locus_tag="Mb1935c" FT /product="PROBABLE LIGNIN PEROXIDASE LIPJ" FT /note="Mb1935c, lipJ, len: 462 aa. Equivalent to Rv1900c, FT len: 462 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 462 aa overlap). Probable lipJ, lignin FT peroxidase, with some similarity to esterases, hydrolases FT and hypothetical Mycobacterium tuberculosis proteins e.g. FT Q43936 BETA-KETOADIPATE ENOL-LACTONE HYDROLASE from FT Acinetobacter calcoaceticus (267 aa), FASTA results: opt: FT 217, E(): 1.7e-07, (29.2% identity in 260 aa overlap). Also FT similar to other Mycobacterium tuberculosis hypothetical FT proteins e.g. Rv2212|Q10400|YM12_MYCTU (378 aa), FASTA FT results: opt: 216, E(): 6.7e-07, (27.7% identity in 285 aa FT overlap)." FT /db_xref="GOA:Q7TZB8" FT /db_xref="HSSP:1FX4" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7TZB8" FT /protein_id="CAD94637.1" FT /translation="MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSI FT DDEPSLYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAVGCEQ FT ATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARPLWAPDYPVGAQVRRADPFLTVAL FT EPDAVEQGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPSMARAVSKVIAEADVRDVLG FT HIEAPTLILHRVGSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEF FT ITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGRE FT VNTAGDGFVATFTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHGTDVAGV FT AVHIGARVCALAGPSEVLVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDA FT TRTR" FT CDS 223942..225234 FT /transl_table=11 FT /gene="cinA" FT /locus_tag="Mb1936" FT /product="PROBABLE CINA-LIKE PROTEIN CINA" FT /note="Mb1936, cinA, len: 430 aa. Equivalent to Rv1901, FT len: 430 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 430 aa overlap). Probable cinA-like FT protein, strong similarity to competence damage proteins FT CinA of Bacillus subtilis and S. pneumoniae. FASTA results: FT Q55760 HYPOTHETICAL 44.7 KD PROTEIN (416 aa) opt: 755, E(): FT 0, (36.0% identity in 433 aa overlap)." FT /db_xref="GOA:P63776" FT /db_xref="InterPro:IPR001453" FT /db_xref="UniProtKB/Swiss-Prot:P63776" FT /protein_id="CAD94638.1" FT /translation="MAVSARAGIVITGTEVLTGRVQDRNGPWIADRLLELGVELAHITI FT CGDRPADIEAQLRFMAEQGVDLIVTSGGLGPTADDMTVEVVARYCGRELVLDDELENRI FT ANILKKLMGRNPAIEPANFDSIRAANRKQAMIPAGSQVIDPVGTAPGLVVPGRPAVMVL FT PGPPRELQPIWSKAIQTAPVQDAIAGRTTYRQETIRIFGLPESSLADTLRDAEAAIPGF FT DLVEITTCLRRGEIEMVTRFEPNAAQVYTQLARLLRDRHGHQVYSEDGASVDELVAKLL FT TGRRIATAESCTAGLLAARLTDRPGSSKYVAGAVVAYSNEAKAQLLGVDPALIEAHGAV FT SEPVAQAMAAGALQGFGADTATAITGIAGPSGGTPEKPVGTVCFTVLLDDGRTTTRTVR FT LPGNRSDIRERSTTVAMHLLRRTLSGIPGSP" FT CDS complement(225286..226554) FT /transl_table=11 FT /gene="nanT" FT /locus_tag="Mb1937c" FT /product="PROBABLE SIALIC ACID-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN NANT" FT /note="Mb1937c, nanT, len: 422 aa. Equivalent to Rv1902c, FT len: 422 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 422 aa overlap). Probable nanT, sialic FT acid-transport integral membrane protein, possibly member FT of major facilitator superfamily (MFS), similar to others FT e.g. Q48076 SIALIC ACID TRANSPORTER (407 aa), FASTA FT results: opt: 443, E(): 5.4e-22, (26.7% identity in 389 aa FT overlap); etc. Some similarity to MTCI364.12|O05301 FT conserved hypothetical protein from Mycobacterium FT tuberculosis (425 aa), FASTA results: opt: 251, E(): FT 1.1e-09, (23.5% identity in 417 aa overlap). Contains sugar FT transport proteins signature 2 (PS00217)." FT /db_xref="GOA:Q7TZB7" FT /db_xref="InterPro:IPR004742" FT /db_xref="UniProtKB/TrEMBL:Q7TZB7" FT /protein_id="CAD94639.1" FT /translation="MAAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHT FT KTDVAFLTTATLAMRPVGALLFGLWADRVGRRVPLMVDVSFYSVIGFLCAFAPNFTVLV FT ILRLLYGIGMGGEWGLGAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVMNWL FT GLSWRWLFGLSIIPALISLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFV FT YLVLLMTAFNWMSHGTQDVYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGT FT LSQRFSRRYTIVFCAALGLPIVPLFAYSRTAAMLCLGSFLMQVFVQGAWGVIPAHLTEM FT SPDAIRGVYPGVTYQLGNLLAAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIG FT KDATGIRFGTTETAFLVRHRNRH" FT CDS 226644..227048 FT /transl_table=11 FT /gene="Mb1938" FT /locus_tag="Mb1938" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb1938, -, len: 134 aa. Equivalent to Rv1903, len: FT 134 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 134 aa overlap). Probable conserved FT membrane protein, similar to Q53868|YPT3_STRCO hypothetical FT 15.9 kd protein from Streptomyces coelicolor (148 aa) opt: FT 323, E(): 1.3e-16, (42.9% identity in 126 aa overlap); and FT equivalent to AJ000521|MLCOSL672_3 from Mycobacterium FT leprae (139 aa), FASTA results: opt: 680, E(): 0, (80.6% FT identity in 129 aa overlap)." FT /db_xref="InterPro:IPR007165" FT /db_xref="UniProtKB/TrEMBL:Q7TZB6" FT /protein_id="CAD94640.1" FT /translation="MVPFLMRAAVTGFALWVVTLFVPGMRFAGGDTTLQRVAIIFVVAV FT IFGLVNAFIKPIVQILSIPLYILTLGLFHVVVNASMLWLTAWITEHTTHWGLQIDHFWW FT TAIWAAILLSIVSWILSLLARDFRRVTRAH" FT CDS 227234..227665 FT /transl_table=11 FT /gene="Mb1939" FT /locus_tag="Mb1939" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1939, -, len: 143 aa. Equivalent to Rv1904, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 143 aa overlap). Conserved hypothetical FT protein, some similarity to other hypothetical FT Mycobacterium tuberculosis proteins e.g. FT Rv2638|MTCY441.08|P71937 (148 aa), FASTA results: opt: 456, FT E( ): 2.7e-23, (52.8% identity in 125 aa overlap); FT Rv1365|Q11035 (128 aa), FASTA results: opt: 393, E(): FT 1.4e-19, (48.8% identity in 123 aa overlap); and Rv3687c. FT Also weak similarity to Q9WVX8|RSBV_STRCO ANTI-SIGMA B FT FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa)." FT /db_xref="GOA:Q7TZB5" FT /db_xref="InterPro:IPR003658" FT /db_xref="UniProtKB/TrEMBL:Q7TZB5" FT /protein_id="CAD94641.1" FT /translation="MRTVAIGPGAGPSSTRPSSQPSDLHSGLRAVTECTGSAVVVHVGG FT DIDASNEVAWQRLVSKSAAIAIAPGPFVIDIRDLDFMGSCAYAVLAQESVRCRRRGVNM FT RLVSNQPIVARTIAACGLRRLIPLYAMVETALAPPPSAH" FT CDS complement(227713..228675) FT /transl_table=11 FT /gene="aao" FT /locus_tag="Mb1940c" FT /product="PUTATIVE D-AMINO ACID OXIDASE AAO" FT /EC_number="1.4.3.3" FT /note="Mb1940c, aao, len: 320 aa. Equivalent to Rv1905c, FT len: 320 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 320 aa overlap). Probable aao, D-amino FT acid oxidase (EC 1.4.3.3), similar to many. Equivalent to FT AJ000521|MLCOSL672.02|O33145 Mycobacterium leprae (320 aa), FT FASTA results: opt: 1541, E(): 0, (71.7% identity in 315 aa FT overlap); also similar to OXDD_BOVIN|P31228 d-aspartate FT oxidase (EC 1.4.3.1) from bos taurus (338 aa), FASTA FT results: opt: 461, E(): 1.1e-21, (31.8% identity in 321 aa FT overlap)." FT /db_xref="GOA:Q7TZB4" FT /db_xref="HSSP:1C0P" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZB4" FT /protein_id="CAD94642.1" FT /translation="MAIGEQQVIVIGAGVSGLTSAICLAEAGWPVRVWAAALPQQTTSA FT VAGAVWGPRPKEPVAKVRGWIEQSLHVFRDLAKDPATGVRMTPALSVGDRIETGAMPPG FT LELIPDVRPADPADVPGGFRAGFHATLPMIDMPQYLDCLTQRLAATGCEIETRPLRSLA FT EAAEAAPIVINCAGLGARELAGDATVWPRFGQHVVLTNPGLEQLFIERTGGSEWICYFA FT HPQRVVCGGISIPGRWDTTPEPEITERILQRCRRIQPRLAEAAVIETITGLRPDRPSVR FT VEAEPIGRALCIHNYGHGGDGVTLSWGCAREVVNLVGGG" FT CDS complement(228705..229175) FT /transl_table=11 FT /gene="Mb1941c" FT /locus_tag="Mb1941c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1941c, -, len: 156 aa. Equivalent to Rv1906c, len: FT 156 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 156 aa overlap). Conserved hypothetical FT protein, possibly exported protein, equivalent to FT Mycobacterium leprae AJ000521|MLCOSL672.01 (153 aa), FASTA FT scores: opt: 637, E(): 2.6e-28, (63.2% identity in 155 aa FT overlap). Also similar to M. tuberculosis hypothetical FT exported protein, Rv1352." FT /db_xref="UniProtKB/TrEMBL:Q7TZB3" FT /protein_id="CAD94643.1" FT /translation="MRLKPAPSPAAAFAVAGLILAGWAGSVGLAGADPEPAPTPKTAID FT SDGTYAVGIDIAPGTYSSAGPVGDGTCYWKRMGNPDGALIDNALSKKPQVVTIEPTDKA FT FKTHGCQPWQNTGSEGAAPAGVPGPEAGAQLQNQLGILNGLLGPTGGRVPQP" FT CDS complement(229515..230162) FT /transl_table=11 FT /gene="Mb1942c" FT /locus_tag="Mb1942c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1942c, -, len: 215 aa. Equivalent to Rv1907c, len: FT 215 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 215 aa overlap). Hypothetical unknown FT protein. Similar to Q50763 Ethyl methane sulphonate FT resistance protein from Mycobacterium tuberculosis (168 FT aa), FASTA scores: opt: 638, E(): 0, (69.7% identity in 152 FT aa overlap). Downstream of a cloned katG gene FT (EMBL:MTKATG). Differences are due to frameshift errors in FT the EMBL sequence and the use of an earlier start codon." FT /db_xref="UniProtKB/TrEMBL:Q7TZB2" FT /protein_id="CAD94644.1" FT /translation="MIGPARRSTTTRRSTPRADRLAGCWCLPGAICQTPRAWWSQARRD FT GDDETGMRRKGAEMCWMCDHPEATAEEYLDEVYGIMLMHGWAVQHVECERRPFAYTVGL FT TRRGLPELVVTGLSPRRGQRLLNIAARRALVGDLLTPGMQTTLPAGPLVETVQVTHPDA FT HLYCAIAIFGDKVTALQLVWADRRGRWPWAADFDEGRGTQPVLGMRATRRSA" FT CDS complement(230169..232391) FT /transl_table=11 FT /gene="katG" FT /locus_tag="Mb1943c" FT /product="CATALASE-PEROXIDASE-PEROXYNITRITASE T KATG" FT /EC_number="1.11.1.6" FT /note="Mb1943c, katG, len: 740 aa. Equivalent to Rv1908c, FT len: 740 aa, from Mycobacterium tuberculosis strain H37Rv FT (99.9% identity in 740 aa overlap). katG, FT catalase-peroxidase-peroxynitritase T (EC 1.11.1.6) (see FT citations below), HPI. FASTA results: Q57215 FT CATALASE-PEROXIDASE from Mycobacterium tuberculosis (740 FT aa) opt: 5081, E(): 0, (100% identity in 740 aa overlap). FT Contains peroxidases active site signature (PS00436) and FT ATP/GTP-binding site motif A (P-loop; PS00017). Cosmid FT sequence was corrected to agree with a sequencing read from FT the H37Rv genome. DELETIONS OR DEFECTS IN KATG GENE CAUSE FT ISONIAZID (INH) RESISTANCE. BELONGS TO THE PEROXIDASE FT FAMILY. BACTERIAL PEROXIDASE/CATALASE SUBFAMILY. KATG FT TRANSCRIPTION SEEMS TO BE REGULATED BY FURA|Rv1909c FT PRODUCT. The catalase-peroxidase activity is associated FT with the amino-terminal domain but no definite function has FT been assigned to the carboxy-terminal domain." FT /db_xref="GOA:P46817" FT /db_xref="HSSP:1MWV" FT /db_xref="InterPro:IPR019793" FT /db_xref="UniProtKB/Swiss-Prot:P46817" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94645.1" FT /translation="MPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNL FT KVLHQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIR FT MAWHAAGTYRIHDGRGGAGGGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWAD FT LIVFAGNCALESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAA FT VQMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGAGPA FT DLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTNTPTKWDNSFLEILYGYE FT WELTKSPAGAWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDLSLRVDPIYERITRRWLE FT HPEELADEFAKAWYKLIHRDMGPVARYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASL FT KSQILASGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKV FT IRTLEEIQESFNSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQ FT EQTDVESFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEMTVLVGGLRVLG FT ANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKDGSGKVKWTGSRV FT DLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR" FT CDS complement(232429..232881) FT /transl_table=11 FT /gene="furA" FT /locus_tag="Mb1944c" FT /product="FERRIC UPTAKE REGULATION PROTEIN FURA (FUR)" FT /note="Mb1944c, furA, len: 150 aa. Equivalent to Rv1909c, FT len: 150 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 150 aa overlap). furA, Ferric uptake FT regulation protein (see first, second and fourth citations FT below), similar to Q48835 LEGIONELLA PNEUMOPHILA 130B FT (WADSWORTH) FERRIC UPTAKE REGULATION (136 aa), FASTA FT results: opt: 230, E(): 2.5e-09, (32.3% identity in 133 aa FT overlap). Also similar to Mycobacterium tuberculosis furB FT ferric uptake regulatory protein, Rv2359. BELONGS TO THE FT FUR FAMILY." FT /db_xref="GOA:P0A583" FT /db_xref="InterPro:IPR002481" FT /db_xref="UniProtKB/Swiss-Prot:P0A583" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94646.1" FT /translation="MSSVSSIPDYAEQLRTADLRVTRPRVAVLEAVNAHPHADTETIFG FT AVRFALPDVSRQAVYDVLHALTAAGLVRKIQPSGSVARYESRVGDNHHHIVCRSCGVIA FT DVDCAVGEAPCLTASDHNGFLLDEAEVIYWGLCPDCSISDTSRSHP" FT CDS complement(232986..233579) FT /transl_table=11 FT /gene="Mb1945c" FT /locus_tag="Mb1945c" FT /product="PROBABLE EXPORTED PROTEIN" FT /note="Mb1945c, -, len: 197 aa. Equivalent to Rv1910c, len: FT 197 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.000% identity in 197 aa overlap). Possible exported FT protein, very similar to upstream ORF MTCY180.07 (201 aa), FT FASTA score: E(): 0, (64.0% identity in 200 aa overlap). FT Also similar to Q9Z729|Y877_CHLPN PROTEIN CPN0877 from FT Chlamydophila pneumoniae (150 aa)." FT /db_xref="HSSP:1FUX" FT /db_xref="InterPro:IPR005247" FT /db_xref="UniProtKB/Swiss-Prot:P67223" FT /protein_id="CAD94647.1" FT /translation="MAHAFHRFALAILGLALPVALVAYGGNGDSRKAAPLAPKAAALGR FT SMPETPTGDVLTISSPAFADGAPIPEQYTCKGANIAPPLTWSAPFGGALVVDDPDAPRE FT PYVHWIVIGIAPGAGSTADGETPGGGISLPNSSGQPAYTGPCPPAGTGTHHYRFTLYHL FT PAVPPLAGLAGTQAARVIAQAATMQARLIGTYEG" FT CDS complement(233662..234267) FT /transl_table=11 FT /gene="lppC" FT /locus_tag="Mb1946c" FT /product="PROBABLE LIPOPROTEIN LPPC" FT /note="Mb1946c, lppC, len: 201 aa. Equivalent to Rv1911c, FT len: 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 201 aa overlap). Probable lipoprotein FT lppC, contains appropriately positioned prokaryotic FT membrane lipoprotein lipid attachment site (PS00013). Very FT similar to downstream ORF MTCY180.08 (204 aa) (although FT this lacks lipoprotein motif), FASTA score: opt: 831, E(): FT 0, (64.0% identity in 200 aa overlap). Also similar to FT Q9Z729|Y877_CHLPN HYPOTHETICAL PROTEIN CPN0877 from FT Chlamydia pneumoniae (strain CWL029) (150 aa)." FT /db_xref="InterPro:IPR005247" FT /db_xref="UniProtKB/Swiss-Prot:P67225" FT /protein_id="CAD94648.1" FT /translation="MTSTLHRTPLATAGLALVVALGGCGGGGGDSRETPPYVPKATTVD FT ATTPAPAAEPLTIASPMFADGAPIPVQFSCKGANVAPPLTWSSPAGAAELALVVDDPDA FT VGGLYVHWIVTGIAPGSGSTADGQTPAGGHSVPNSGGRQGYFGPCPPAGTGTHHYRFTL FT YHLPVALQLPPGATGVQAAQAIAQAASGQARLVGTFEG" FT CDS complement(234367..235371) FT /transl_table=11 FT /gene="fadB5" FT /locus_tag="Mb1947c" FT /product="POSSIBLE OXIDOREDUCTASE FADB5" FT /EC_number="1.-.-.-" FT /note="Mb1947c, fadB5, len: 334 aa. Equivalent to Rv1912c, FT len: 334 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 334 aa overlap). Possible fadB5, FT oxidoreductase (EC 1.-.-.-), similar to various FT oxidoreductases: 3-hydroxyacyl-CoA dehydrogenase (EC FT 1.1.1.35), quinone oxidoreductases (EC 1.6.5.5), and FT polyketide synthases, e.g. NP_104067.1|NC_002678 probable FT oxidoreductase from Mesorhizobium loti (308 aa); FT NP_464140.1|NC_003210 protein similar to oxidoreductase FT from Listeria monocytogenes (313 aa); NP_193889.1|NC_003075 FT putative NADPH quinone oxidoreductase from Arabidopsis FT thaliana (325 aa); NP_001880.2|NM_001889 crystallin, zeta; FT quinone oxidoreductase; NADPH:quinone reductase from Homo FT sapiens (329 aa); part 2983 to 3197 of T17410 polyketide FT synthase type I from Streptomyces venezuelae (3739 aa); FT Q53927|SCBAC20F6.16 HYDROXYACYL-COA DEHYDROGENASE from FT Streptomyces coelicolor (329 aa), FASTA scores: opt: 621, FT E(): 2e-30, (39.5% identity in 349 aa overlap); etc. Also FT similar to many hypothetical Mycobacterium tuberculosis FT proteins including: MTCY24G1.09, MTCY13D12.11, MTCY19H9.01, FT MTCY24G1.03, MTCY03A2.17c, etc. Contains quinone FT oxidoreductase/zeta-crystallin signature (PS01162)." FT /db_xref="GOA:Q7TZB1" FT /db_xref="HSSP:1IYZ" FT /db_xref="InterPro:IPR013154" FT /db_xref="UniProtKB/TrEMBL:Q7TZB1" FT /protein_id="CAD94649.1" FT /translation="MRAVVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFADH FT LARVGLYPDAPKLPAVVGYEVAGTVEAVGDGVDPNRVGERVLAGTRFGGYCEIVNVAAT FT DSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLRAGERVLIHAAAGGVGIAAVQFAKA FT AKAEVHGTASPQKHQKLAEFGVDRAIDYRRDGWWQGLGPYDVVLDALGGTSLRRSYTLL FT RPGGRLVGYGISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRLWDD FT RRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAPEAHRILAARENVGKVVLVP" FT CDS 235471..236223 FT /transl_table=11 FT /gene="Mb1948" FT /locus_tag="Mb1948" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1948, -, len: 250 aa. Equivalent to Rv1913, len: FT 250 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 250 aa overlap). Conserved hypothetical FT protein, slight similarity to dehydrase and beta-lactamase FT precursors e.g. Q02057 DEHYDRASE from Streptomyces FT coelicolor (297 aa), FASTA scores: opt: 184, E(): 4.3e-05, FT (31.6% identity in 215 aa overlap)." FT /db_xref="GOA:Q7TZB0" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:Q7TZB0" FT /protein_id="CAD94650.1" FT /translation="MHFDWERLTDSVHRCRLPFCDVTVGLVRGRTGILLVDTGTTLGEA FT TAIAADVKQIAGCQVTHVVLTHKHFDHVLGSSVFDQAEVFCAPEVVEYLRSATDRLRED FT ALSYGADTAEVDRAIAALKPPQHGIYDAAVDLGDRTVTITHPGSGHTTADLVVVAPATG FT HADGPTVVFTGDLVEESADPDIDADSDLAAWPATLDRVLAIGGPDASYVPGHGKVVDAQ FT FVRRQRAWLRTRASRQPRETPATLPCKR" FT CDS complement(236201..236608) FT /transl_table=11 FT /gene="Mb1949c" FT /locus_tag="Mb1949c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1949c, -, len: 135 aa. Equivalent to Rv1914c, len: FT 135 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 135 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZA9" FT /protein_id="CAD94651.1" FT /translation="MVLSRTSTGRVILVPTQLRFDRWFLPLAVPLGLGPKNSELWVGAG FT SLHVKMGWAFAADIPLTSITKAEATNARVYAAGVHFGFGRWLVNGSRKGLVALTIDPPE FT QAKMWKKSMTVRELWVSVTDPDALVTACTAK" FT CDS 236743..239043 FT /transl_table=11 FT /gene="aceA" FT /locus_tag="Mb1950" FT /product="PROBABLE ISOCITRATE LYASE aceA (ISOCITRASE) FT (ISOCITRATASE) (ICL)" FT /EC_number="4.1.3.1" FT /note="Mb1950, aceA, len: 766 aa. Similar to Rv1915 and FT Rv1916, len: 367 aa and 398 aa, from Mycobacterium FT tuberculosis strain H37Rv, (89.1% identity in 339 aa FT overlap and 100.0% identity in 398 aa overlap). Probable FT aceA, isocitrate lyase (EC 4.1.3.1). Contains PS00161 FT Isocitrate lyase signature. REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb FT exist as 2 genes. In Mycobacterium bovis, a single base FT insertion (*-t) leads to a single product." FT /db_xref="GOA:Q7TZA8" FT /db_xref="HSSP:1IGW" FT /db_xref="InterPro:IPR018523" FT /db_xref="UniProtKB/TrEMBL:Q7TZA8" FT /protein_id="CAD94652.1" FT /translation="MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQ FT VVEQRGTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIY FT LGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRA FT ATPAYDFRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKV FT LVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDV FT PSYKSCFLAMVRRFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGLVSDAVNAWR FT EDGQQSIDGIFDQVESRFVAAWEDDAGLMTYGEAVADVLEFGQSEGEPIGMAPEEWRAF FT AARASLHAARAKAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWM FT ETKTADLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFV FT FNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDA FT ALAASSGRTATTKAMGKGSTQHQHLVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQ FT RAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHL FT WLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTP FT DRVALRKLITKEA" FT CDS complement(239213..244945) FT /transl_table=11 FT /gene="PPE34" FT /locus_tag="Mb1951c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1951c, PPE34, len: 1910 aa. Similar to Rv1917c, FT len: 1459 aa, from Mycobacterium tuberculosis strain H37Rv. FT Member of the Mycobacterium tuberculosis PPE family of FT glycine-rich proteins, MPTR subfamily (see citation below). FT Similar to MTCY28.16, MTCY13E10.17, MTCY63.10, MTV004.05 , FT MTCY98.24, MTCY6G11.05, etc. C-terminus is identical to FT Q50471. Unknown Mycobacterium tuberculosis protein (693 FT aa), FASTA results: opt: 2635, E(): 0, (99.7% identity in FT 391 aa overlap). Start changed since original submission FT (+23 aa). Thougth to be surface exposed, cell-wall FT associated. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, deletions of 12 bp and 69 bp, insertions of 483 bp FT and 375 bp, and a large substitution of 52 bp to 628 bp, FT leads to a longer product compared to the homolog in FT Mycobacterium tuberculosis strain H37Rv (1910 aa versus FT 1459 aa)." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7TZA7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94653.1" FT /translation="MNFSTLPPEINSALIFGGAGSEPMSAAAVAWDQLAMELASAAASF FT NSVTSGLVGESWLGPSSAAMAAAVAPYLGWLAAAAAQAQRSATQAAALVAEFEAVRAAM FT VQPALVAANRSDLVSLVFSNFFGQNAPAIAAIEAAYEQMWAIDVSVMSAYHAGASAVAS FT ALTPFTAPPQNLTDLPAQLAAAPAAVVTAAITSSKGVLANLSLGLANSGFGQMGAANLG FT ILNLGSLNPGGNNFGLGNVGSNNVGLGNTGNGNIGFGNTGNGNIGFGLTGDNQQGFGGW FT NSGTGNIGLFNSGTGNIGIGNTGTGNFGIGNSGTSYNTGIGNTGQANTGFFNAGIANTG FT IGNTGNYNTGSFNLGSFNTGDFNTGSSNTGFFNPGNLNTGVGNTGNVNTGGFNSGNYSN FT GFFWRGDYQGLIGFSGTLTIPAAGLDLNGLGSVGPITIPSITIPEIGLGINSSGALVGP FT INVPPITVPAIGLGVSSSGALVGPINVPPITVPAIGLGVSSSGALVGPINVPPITVPAI FT GLGVSSSGALVGPINVPPITVPAIGLGVSSSGALVGPINVPPITVPAIGLGVSSSGALV FT GPINVPPITVPAIGLGVSSSGALVGPINVPPITVPAIGLGVSSSGALVGPINVPPITVP FT AIGLGVSSSGALVGPINVPPITVPAIGLGVSSSGALVGPINVPPITLNSIGLELSAFQV FT INVGSISIPASPLAIGLFGVNPTVGSIGPGSISIQLGTPEIPAIPPFFPGFPPDYVTVS FT GQIGPITFLSGGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVF FT PDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAI FT PLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGG FT LGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGAIGPLTTPPI FT TIPAIPLGIDVSGSLGPINIPIEIAGTPGFGNSTTTPSSGFFNSGTGGTSGFGNVGSGG FT SGFWNIAGNLGNSGFLNVGPLTSGILNFGNTVSGLYNTSTLGLATSAFHSGVGNTDSQL FT AGFMRNAAGGTLFNFGFANDGTLNLGNANLGDYNVGSGNVGSYNFGSGNIGNGSFGFGN FT IGSNNFGFGNVGSNNLGFANTGPGLTEALHNIGFGNIGGNNYGFANIGNGNIGFGNTGT FT GNIGIGLTGDNQVGFGALNSGSGNIGFFNSGNGNIGFFNSGNGNVGIGNSGNYNTGLGN FT VGNANTGLFNTGNVNTGIGNAGSYNTGSYNAGDTNTGDLNPGNANTGYLNLGDLNTGWG FT NIGDLNTGALISGSYSNGILWRGDYQGLIGYSDTLSIPAIPLSVEVNGGIGPIVVPDIT FT IPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGG FT VGPIVVPDITIPGIPLSLNALGGVGPITVPGVPISRIPLTINIRIPVNITLNELPFNVA FT GIFTGYIGPIPLSTFVLGVTLAGGTLESGIQGFSVNPFGLNIPLSGATNAVTIPGFAIN FT PFGLNVPLSGGTSPVTIPGFAINPFGLDVPLSGGTNAVTIPGFAINPFGLDVPLSGGTS FT PVTIPGFAINPFGLDVPLSGGTNAVTIPGFAINPFGLDVPLSGGTNAVTIPGFAINPFG FT LDVPLSGGTSPVTIPGFAINPFDLNVPLSGGTNAVTIPGFAINPFGLNVPLSGGTSPVT FT IPGFAINPFGLNVPLSGGTSPVTIPGFTIPGSPLNLTANGGLGPINITSAPGFGNSTTT FT PSSGFFNSGDGSASGFGNVGPGISGLWNQVPNALQGGVSGIYNVGQLASGVANLGNTVS FT GFNNTSTVGHLTAAFNSGVNNIGQMLLGFFSPGAGP" FT CDS complement(245283..246287) FT /pseudo FT /transl_table=11 FT /gene="PPE35b" FT /locus_tag="Mb1952c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1952c, PPE35b, len: 334 aa. Equivalent to 3' end FT of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.1% identity in 334 aa overlap). Member of FT the Mycobacterium tuberculosis PPE family of glycine-rich FT proteins. Similar to MTCY28.16|Z95890 M. tuberculosis FT cosmid (1053 aa), FASTA scores: opt: 3404, E(): 0, (65.6% FT identity in 1058 aa overlap). Also similar to MTV004.05, FT MTY13E10.17, MTV014.03, MTCY3C7.23, MTCY6G11.05, MTCY48.17, FT MTV004.03, MTCY31.07, MTCY4C12.36, MTCY180.01, etc. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, PPE35 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT insertion (*-t) splits PPE35 into 2 parts, PPE35a and FT PPE35b." FT /db_xref="PSEUDO:CAD94654.1" FT CDS complement(246370..248247) FT /transl_table=11 FT /gene="PPE35a" FT /locus_tag="Mb1953c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1953c, PPE35a, len: 625 aa. Equivalent to 5'end of FT Rv1918c, len: 987 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 599 aa overlap). Member FT of the Mycobacterium tuberculosis PPE family of FT glycine-rich proteins. Similar to MTCY28.16|Z95890 M. FT tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404, FT E(): 0, (65.6% identity in 1058 aa overlap). Also similar FT to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23, FT MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36, FT MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base insertion (*-t) splits PPE35 into 2 parts, FT PPE35a and PPE35b." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7TZA6" FT /protein_id="CAD94655.1" FT /translation="MHYSVLPPEINSALIFAGAGSGPMLAAASAWDGLATELASAAVSF FT GSVTAGLVGGSWQGRSSVAMAAAAAPYAGWLAAAATQAEQAATQAQVMVAEFEAVRLAM FT VQPALVAANRSGLISLVISNLFGQNAPAIAAAEAAYEEMWALDVSAMAAYHSGASAVAV FT ALPAFALPLRLPAGLAAGPAAVVTALTTAVGMPTFAGRAIAASLGLANVGGGNLGNANN FT GLGNIGNANLGNNNLGSGNFGSFNIGSANLGGNNIGIGNAGANNFGLANLGNLNTGFAN FT AGIGNFGIANTGNNNIGNGLTGNNQIGIGGLNSGNGNVGLFNAGSANIGFFNSGNGNFG FT IGNSGNFSTGLFNPGHGNTGFLNAGSFNTGMFDVGNANTGSFNVGHYNFGAFNPGPSNT FT GTFNTGGANTGWFNTGSINTGAFNIGDMNNGLFNTGDMNNGVFYRGVGQGSLQFAITSP FT DLTLPSLEIPGISVPAFSLPAITLPSLTIPAVTTPANVTVGAFDLPGLTVPSLTIPAAM FT TPANITVGAFDLPGLTVPSLTIPATTTPANITVGAFNLPQLSIPSVTVPPITIPAGTAL FT GAFNLPTLSIPSVTVPPITIPAGNHCRRIYATHDTHPVNKYTPNKYRRL" FT CDS complement(248696..249160) FT /transl_table=11 FT /gene="Mb1954c" FT /locus_tag="Mb1954c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1954c, -, len: 154 aa. Equivalent to Rv1919c, len: FT 154 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 154 aa overlap). Conserved hypothetical FT protein, shows weak similarity to several major pollen FT antigens e.g. Z72431|BVGC25_1 MAJOR ALLERGEN BET V 1 from FT Betula verrucosa (160 aa), FASTA scores: opt: 133, E(): FT 0.012, (26.8% identity in 149 aa overlap). Also shows some FT similarity to Rv2574|MTCY227.27C Hypothetical protein from FT Mycobacterium tuberculosis (167 aa), (27.4% identity in 124 FT aa overlap)." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/TrEMBL:Q7TZA5" FT /protein_id="CAD94656.1" FT /translation="MSGRKFSFEVTKTSSAPAATLFRLVTDGGNWATWAKPIVAQSSWA FT RRGDPAPGGIGAIRKLGMWPVFVQEETVEYEQDRRHVYKLVGARTPVQDYFGEVVLTPN FT ASGGTDLRWSGSFTEKVRGTGPVMRAALGGAVRFFAGQLVKAAEREAVRR" FT CDS 249258..250121 FT /transl_table=11 FT /gene="Mb1955" FT /locus_tag="Mb1955" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb1955, -, len: 287 aa. Equivalent to Rv1920, len: FT 287 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 287 aa overlap). Probable membrane FT protein, similar to AL0215|SC10A5.04 putative membrane FT protein from Streptomyces coelicolor cosmid 10A5 (295 aa), FT FASTA scores: opt: 292, E(): 3.6e-13, (31.3% identity in FT 243 aa overlap). Also weakly similar to several FT Mycobacterial putative proteins with unknown function e.g. FT Rv0502, Rv1428c, U00018_22 Mycobacterium leprae cosmid FT B2168." FT /db_xref="GOA:Q7TZA4" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/TrEMBL:Q7TZA4" FT /protein_id="CAD94657.1" FT /translation="MFPRWPQQAHNHEVSRADTVSVPRAPTQAEVAAVLRIMTPLRKVI FT KPKVYGIENVPTERALLVGNHNTLGLVDAPLLAAELWERGRIVRSLGDHAHFKIPGWRD FT ALTRTGVVEGTREITSELMRRGELVIVFPGGAREVNKRKNERYKLVWKNRLGFARLAIQ FT HGYPIVPFASVGAEHGIDIVLDNESPLLAPVQFLAEKLLGTKDGPALVRGVGLTPVPRP FT ERQYYWFGEPIDTTEFMGQQADDNAARRVRERAAAAIEHGIELMLAERAADPNRSLVGR FT LLRSDA" FT CDS complement(250159..251430) FT /transl_table=11 FT /gene="lppF" FT /locus_tag="Mb1956c" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPPF" FT /note="Mb1956c, lppF, len: 423 aa. Equivalent to Rv1921c, FT len: 423 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 423 aa overlap). Probable lppF, FT conserved lipoprotein, similar to G403173 lipoprotein FT precursor (fragment) from Rhodococcus erythropolis (225 FT aa), fasta scores: opt: 364, E(): 9.2e-19, (41.9% identity FT in 148 aa overlap). Contains PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="UniProtKB/TrEMBL:Q7TZA3" FT /protein_id="CAD94658.1" FT /translation="MVRLIPSLLAMATVLGGVIGCSAHQPPTPASGCRQLDAFLKWHHG FT VREFLQSAIDANSRCTGTADGSARKVAIFDWDNTVVKNDIGYATNYYMLQHSLVLQPAN FT QDWHAASRYLTDAAANALSVACGKVVPAGKPLPTGSNALCANEILSLLDGETTTGQPAF FT VGNNVRRLAGPYAWSNALSAGYTAEELAGFADQAKKQNLAADVGATQQVGTQQVDGYIR FT VYPQMKDLIGTLQAHGIDTWVVSASPEPIVKVWAGEVGLDDQHVVGVRSVADQSGKLTA FT HLVGCGGVRDGDDSVMTYLDGKRCWANQVIFGVTGPQAFNQLAADRRQVLAAGDSNSDA FT TFVGDATVVSLVINRNQDDLMCRAYDGLFTRGGKWAINPMFIDPLPQHAPYVCGEAFIN FT PDGSKQPVLRNDGTPIPDQVDSVF" FT CDS 251702..252817 FT /transl_table=11 FT /gene="Mb1957" FT /locus_tag="Mb1957" FT /product="PROBABLE CONSERVED LIPOPROTEIN" FT /note="Mb1957, -, len: 371 aa. Equivalent to Rv1922, len: FT 371 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 371 aa overlap). Probable conserved FT lipoprotein, possibly peptidase (EC 3.4.-.-) similar to FT many peptidases, e.g. P15555|DAC_STRSQ D-alanyl-D-alanine FT carboxypeptidase from Streptomyces sp. (406 aa), FASTA FT scores: opt: 382, E(): 3.1e-17, (28.0% identity in 379 aa FT overlap). Also similar to Mycobacterium tuberculosis FT hypothetical proteins Rv1497, Rv2463, Rv3775, etc. Contains FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site." FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q7TZA2" FT /protein_id="CAD94659.1" FT /translation="MDSTVTASIRRMLGLLAATLLLGGCTGQHTTRTAASTTYTPHIKA FT SSQDVLDGAINADEPGCSAAVGVEGKVIWSGVRGIADLASGAKITTDTVFDIASVSKQF FT TATAILLLVEAGKLTLDDPISQYVPELPDWAQTVTVEQLMHQTSGIPDYVALLAARGYQ FT VSDRTIEAEARQALAAAPELQFKPGTRFDYSNSNYLLLGEIVHRASGQPLPEFLSAEIF FT QPLGLAMVVDPVGKVPNKAVSYEKGTGGNRSEYRVGNPAWEQIGDGGIQTTPSQLARWA FT DNYRTGSVGGLKLLEAQLAGAVETEPGGGDRYGAGIVSRADGTLDHAGAWAGFVTAFHI FT SSDRRTSVAISCNTDKPDPVAMADALGRLWM" FT CDS 252808..254148 FT /transl_table=11 FT /gene="lipD" FT /locus_tag="Mb1958" FT /product="PROBABLE LIPASE LIPD" FT /EC_number="3.1.-.-" FT /note="Mb1958, lipD, len: 446 aa. Equivalent to Rv1923, FT len: 446 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 446 aa overlap). Probable lipD, FT hydrolase lipase (EC 3.1.-.-), similar to esterases and FT beta-lactamases e.g. G151214 esterase, (389 aa), fasta FT scores: opt: 569, E(): 5.4e-29, (33.7% identity in 401 aa FT overlap). Also similar to Mycobacterium tuberculosis FT hypothetical proteins Rv1497, Rv2463, Rv3775, etc." FT /db_xref="GOA:Q7TZA1" FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q7TZA1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94660.1" FT /translation="MDVAGLPRLAAGTQAAIIHGMAQPPSLLTTDNGLPFGVQGACDSR FT FTGVIRAFAGLYPGRKFGGGALSVYIDDRQVVDVWTGWSDRQGKVPWTADTGAMVFSAT FT KGLAATVIHRLVDRGLLSYDAPVAEYWPEFGANGKSEVTVSDVLRHRSGLAHLKGVDKD FT EVMDHLLMEQKLAAAPLNRQHGKLAYHAVTYGWLLSGLARAVTGKGMRELFREELARPL FT NTDGIHLGRPPADSPTKAAQTLLPQAKVPTPLLDFIAPKVAGLSFSGLLGAVYFPGILS FT LLQDDMPFLDGEVPAVNGVVTARALAKTYGALANDGVIDGTRLLSSQAVRGLTGKSELW FT PDLNLGLPFTYHQGYQSSPVPGLLEGYGHIGLGGTIGWADPETGSAFGYVHNRLLTLLL FT FDIGSFAGLAALLNSAVVAARRDDPLEVPHFGAPYSEPRHEQAASGA" FT CDS complement(254185..254565) FT /transl_table=11 FT /gene="Mb1959c" FT /locus_tag="Mb1959c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1959c, -, len: 126 aa. Equivalent to Rv1924c, len: FT 126 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 126 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZA0" FT /protein_id="CAD94661.1" FT /translation="MDPADVINPTSTRDAALARVLAYRQRVRARPLLIRATLAVVGGGL FT FVVSLPMIVLLPELGIPALLVAFRLLAVEAQWAVRAYAWTDWRFTQLREWFHRQVLVTR FT AAILVGLFLAAVALVWLLVYEF" FT CDS 254722..256584 FT /transl_table=11 FT /gene="fadD31" FT /locus_tag="Mb1960" FT /product="PROBABLE ACYL-COA LIGASE FADD31 (ACYL-COA FT SYNTHETASE) (ACYL-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1960, fadD31, len: 620 aa. Equivalent to Rv1925, FT len: 620 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 620 aa overlap). Probable fadD31, FT acyl-CoA synthetase (EC 6.2.1.-), highly similar to others FT from Mycobacterium leprae e.g. NP_301198.1|NC_002677 FT putative acyl-CoA synthetase (635 aa); FT NP_302537.1|NC_002677 probable acyl-CoA synthase (583 aa); FT etc. Also highly similar to others from Mycobacterium FT tuberculosis e.g. fadD32 (637 aa); fadD21 (578 aa); fadD29 FT (619 aa); fadD26|FD26_MYCTU|Q10976 (626 aa), FASTA scores: FT opt: 945, E(): 0, (39.8% identity in 598 aa overlap); etc. FT Also similar to N-terminus of G1171128 SAFRAMYCIN MX1 FT SYNTHETASE B from Myxococcus xanthus (1770 aa), FASTA FT scores: opt: 845, E(): 0, (37.4% identity in 593 aa FT overlap); N-terminus of T34918 polyketide synthase from FT Streptomyces coelicolor (2297 aa); etc." FT /db_xref="GOA:Q7TZ99" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TZ99" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94662.1" FT /translation="MNDGSRQELRVRSGLLQIEDCLDADGGIALPAGTTLISLIERNIK FT YVGDLVAYRYLDHARSAAGCALEVTWTQFGMRLAAIGAHVQRFAGPGDRVAILAPQGID FT YVCGFYAAIKAGTVAVPLFAPELPGHAERLDTALRDSEPAVILTTAAAKNAVEGFLNNV FT PRLRKPTVLVIDQIPDREGELFVPVELDIDAVSHLQYTSGSTRPPVGVEITHRAVGTNL FT VQMILSIDLLNRNTHGVSWLPLYHDMGLSMIGFPAVYGGHSTLMSPTAFVRRPLRWIQA FT LSEGSRTGRVVTAAPNFAYEWAAQRGLPAQGDDVDLSNVVLIIGSEPVSIDAVTTFNKA FT FAPYGLPRTAFKPSYGIAEATLLVATIDHAAEPTVVYLDPEQLGAGHATRVAPDAPNAV FT VHVSCGHVARSLWAVIVDPDTGPEAGAELPDGEIGEVWLQGDNVARGYWGRPEETRMTF FT GARLQSPLAEGSHADGSAIDDTWLRTGDLGVYLDGELYITGRIADLLTIDGRNHYPQDI FT EATAAEASPMVRRGYITAFTVPASDGDDRNQRLVIIAERAAGTSRSDPRPALDAIRAAV FT CNRHGLSVADLSFLPAGAIPRTTSGKLARQACRAQYLSGRLGVH" FT CDS complement(256592..257071) FT /transl_table=11 FT /gene="mpt63" FT /locus_tag="Mb1961c" FT /standard_name="mpb63" FT /product="IMMUNOGENIC PROTEIN MPT63 (ANTIGEN MPT63/MPB63) FT (16 KD IMMUNOPROTECTIVE EXTRACELLULAR PROTEIN)" FT /note="Mb1961c, mpt63, len: 159 aa. Equivalent to Rv1926c, FT len: 159 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 159 aa overlap). mpt63 (alternate gene FT name: mpb63), immunogenic protein (see citations below), FT identical to MPT63|MPB63 from Mycobacterium bovis (159 aa). FT Exported protein containing a N-terminal signal sequence: FT see notes below about proteomics." FT /db_xref="GOA:P0A5Q3" FT /db_xref="InterPro:IPR015250" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Q3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94663.1" FT /translation="MKLTTMIKTAVAVVAMAAIATFAAPVALAAYPITGKLGSELTMTD FT TVGQVVLGWKVSDLKSSTAVIPGYPVAGQVWEATATVNAIRGSVTPAVSQFNARTADGI FT NYRVLWQAAGPDTISGATIPQGEQSTGKIYFDVTGPSPTIVAMNNGMEDLLIWEP" FT CDS 257308..258081 FT /transl_table=11 FT /gene="Mb1962" FT /locus_tag="Mb1962" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1962, -, len: 257 aa. Equivalent to Rv1927, len: FT 257 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 257 aa overlap). Conserved hypothetical FT protein, similar to SCG11A.10c|AL133210 hypothetical FT protein from Streptomyces coelicolor (252 aa), FASTA FT scores: opt: 729, E(): 0, (48.3% identity in 238 aa FT overlap). Slight similarity with P54543|YQJF_BACSU FT hypothetical 23.9 kd protein from Bacillus subtilis (209 FT aa), FASTA scores, opt: 230, E(): 2.8e-08, (28.0% identity FT in 164 aa overlap)." FT /db_xref="InterPro:IPR018644" FT /db_xref="UniProtKB/TrEMBL:Q7TZ98" FT /protein_id="CAD94664.1" FT /translation="MTAIPGPSGAEPGESRALAGYPVTPPALPRPVIFDQRWTDLTFIH FT WPVLPESVAGSYPPGTRPDVFADGMTYVGLVPFRMSSTKLGTALPIPYVGTFPETNVRL FT YSIDNAGRHGVLFRSLETARLTVVPLTRIGLGIPYAWSRMRMMRSGKHITYHSVRRWPR FT RGLRSLLTITIGDLVEPTPLEVWLTARWGAHTRKAGRTWWVPNEHKPWPLRAAEIAELN FT DELIDASGVQPTGDRLRALFSPGVHARFGRPCVVQ" FT CDS complement(258085..258852) FT /transl_table=11 FT /gene="Mb1963c" FT /locus_tag="Mb1963c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1963c, -, len: 255 aa. Equivalent to Rv1928c, len: FT 255 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 255 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), highly similar to FT others e.g. NP_228109.1|NC_000853 oxidoreductase (short FT chain dehydrogenase/reductase family) from Thermotoga FT maritima (257 aa); T41116 short chain dehydrogenase from FT Schizosaccharomyces pombe (261 aa); P87219|SOU1_CANAL FT SORBITOL UTILIZATION PROTEIN (SDR FAMILY) from Candida FT albicans (281 aa); P25529|HDHA_ECOLI 7-alpha-hydroxysteroid FT dehydrogenase from Escherichia coli (255 aa), FASTA scores: FT opt: 541, E(): 1.2e-27, (37.5% identity in 251 aa overlap); FT etc. Also similar to many mycobacterial tuberculosis FT proteins e.g. Rv1350, Rv0927c, Rv2002, Rv0769, Rv2766c, FT etc. Contains PS00061 Short-chain alcohol dehydrogenase FT family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7TZ97" FT /db_xref="HSSP:1FJH" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7TZ97" FT /protein_id="CAD94665.1" FT /translation="MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHL FT DALEKLADEIGTSGGKVVPVCCDVSQHQQVTSMLDQVTAELGGIDIAVCNAGIITVTPM FT LDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQGGVIINTASMSGHIINVPQQVSHY FT CASKAAVIHLTKAMAVELAPHKIRVNSVSPGYILTELVEPYTEYQPLWEPKIPLGRLGR FT PEELAGLYLYLASEASSYMTGSDIVIDGGYTCP" FT CDS complement(258897..259541) FT /transl_table=11 FT /gene="Mb1964c" FT /locus_tag="Mb1964c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1964c, -, len: 214 aa. Equivalent to Rv1929c, len: FT 214 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.533% identity in 214 aa overlap). Conserved FT hypothetical protein, similar to SC4G6.14|AL096884 FT hypothetical protein from Streptomyces coelicolor (211 aa), FT FASTA scores: opt: 416, E(): 2.4e-22, (39.8% identity in FT 206 aa overlap)." FT /db_xref="InterPro:IPR017519" FT /db_xref="UniProtKB/TrEMBL:Q83XB9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94666.1" FT /translation="MADVPLDAQERLELCDLLEELGPAVATLIEGWTAHDLAAHIVLRE FT RDLVAGLCIVLPGPFQRFAERRRARLAQSKDFTWLVARIRSGPPMGFFRIGWVRTLANL FT NEFFVHHEDVRRASGRGPRSLTPEMDAALWRNVRRGSHFLSRRLHGCGLEIEWVGTGKR FT VRVRSGEPTARLTGPPGELLLYVFGRRAVARVEVSGPLEAIAAVHRTHFGM" FT CDS complement(259553..260077) FT /transl_table=11 FT /gene="Mb1965c" FT /locus_tag="Mb1965c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1965c, -, len: 174 aa. Equivalent to Rv1930c, len: FT 174 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.000% identity in 174 aa overlap). Conserved FT hypothetical protein, similar to SC5F2A.30|AL049587 FT hypothetical protein from Streptomyces coelicolor (211 aa), FT FASTA scores: opt: 307, E(): 2.8e-13, (54.8% identity in 84 FT aa overlap). Some similarity to M. tuber culosis FT hypothetical protein Rv0052|MTCY21D4.15 (43% identity in 93 FT aa overlap)." FT /db_xref="InterPro:IPR002818" FT /db_xref="UniProtKB/TrEMBL:Q83XB8" FT /protein_id="CAD94667.1" FT /translation="MTQIAFVAYPGVTALDVVGPYEVLRNLPHAQVRFVWLRGRRATSH FT WLTLPALKAFGAIPVADERIVHQDNIVTSAGVSAGLDLALWLAGQLGGEARAKAIQLAI FT EYDPQPPFDSGHMSKASPTTKAAATALLSKDSAKPANLTAATLLAWERALAAVQSRRRK FT RQPVGAQARRP" FT CDS complement(260095..260874) FT /transl_table=11 FT /gene="Mb1966c" FT /locus_tag="Mb1966c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1966c, -, len: 259 aa. Equivalent to Rv1931c, len: FT 259 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 259 aa overlap). Probable FT transcriptional regulatory protein. Similarity in FT C-terminal half to transcriptional activators e.g. Q43970 FT ARAC-LIKE PROTEIN (227 aa), FASTA scores: opt: 238, E(): FT 7.1e-07, (42.4% identity in 92 aa overlap). Similar to many FT probable transcription regulators in Streptomyces e.g. FT AL049587|SC5F2A.29 Streptomyces coelicolor (325 aa), FASTA FT scores: opt: 387, E(): 3.2e-16, (34.4% identity in 259 aa FT overlap)." FT /db_xref="GOA:Q83XB7" FT /db_xref="InterPro:IPR018060" FT /db_xref="UniProtKB/TrEMBL:Q83XB7" FT /protein_id="CAD94668.1" FT /translation="MVIVGFPGDPVDTVILPGGAGVDAARSEPALIDWVKAVSGTARRV FT VTVCTGAFLAAEAGLLGRTPSDDALGLCRTFRPRISGRSGRCRPDLHAQFAEGVDRGWS FT HRRHRPRAGTGRRRPRHRDCPDGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAG FT GHRGRAGGAHRIGELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHD FT TVVAIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA" FT CDS 261007..261504 FT /transl_table=11 FT /gene="tpx" FT /locus_tag="Mb1967" FT /standard_name="cfp20" FT /product="PROBABLE THIOL PEROXIDASE TPX" FT /EC_number="1.11.1.-" FT /note="Mb1967, tpx, len: 165 aa. Equivalent to Rv1932, len: FT 165 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 165 aa overlap). Probable tpx FT (alternate gene name: cfp20), thiol peroxidase (EC FT 1.11.1.-) similar to TPX_ECOLI|P37901 thiol peroxidase (EC FT 1.11.1.-) (p20) from Escherichia coli (167 aa), fasta FT scores: opt: 535, E(): 7.3e-25, (52.4% identity in 164 aa FT overlap). There are four other related enzymes in M. FT tuberculosis: Rv2428, Rv2521, Rv2238c, Rv1608c." FT /db_xref="GOA:P66953" FT /db_xref="HSSP:1PSQ" FT /db_xref="InterPro:IPR002065" FT /db_xref="UniProtKB/Swiss-Prot:P66953" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94669.1" FT /translation="MAQITLRGNAINTVGELPAVGSPAPAFTLTGGDLGVISSDQFRGK FT SVLLNIFPSVDTPVCATSVRTFDERAAASGATVLCVSKDLPFAQKRFCGAEGTENVMPA FT SAFRDSFGEDYGVTIADGPMAGLLARAIVVIGADGNVAYTELVPEIAQEPNYEAALAAL FT GA" FT CDS complement(261501..262592) FT /transl_table=11 FT /gene="fadE18" FT /locus_tag="Mb1968c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE18" FT /EC_number="1.3.99.-" FT /note="Mb1968c, fadE18, len: 363 aa. Equivalent to Rv1933c, FT len: 363 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 363 aa overlap). Probable fadE18, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT CAB61609.1|AL133210 putative acyl-CoA dehydrogenase from FT Streptomyces coelicolor (362 aa); NP_421282.1|NC_002696 FT acyl-CoA dehydrogenase family protein from Caulobacter FT crescentus (344 aa); ACDS_RAT|P15651 short-chain specific FT acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412 FT aa), fasta scores: opt: 239, E(): 2.1e-08, (28.4% identity FT in 331 aa overlap); etc. Also similar to others from FT Mycobacterium tuberculosis e.g. N-terminus of fadE22 (721 FT aa); fadE33 (318 aa); N-terminus of fadE34 (711 aa); etc. FT COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q83XB4" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q83XB4" FT /protein_id="CAD94670.1" FT /translation="MDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSDRRLWQRLCT FT ELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAATVFAIEAILRMGDDEQRK FT RLLAGLLTGARIGTIAVSGHDVASATTVRAVRRDGRPALTGECTPVLHGHVADLFVVPA FT VADGSIVLHVVAADAPGVTVTPLPSFDITRPVATLRLAGSPAEPLTAGTPDDMERVLDV FT ARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVM FT FAAMSAANGDELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTT FT EALFGSSARNRALLAERAGLVKA" FT CDS complement(262594..263823) FT /transl_table=11 FT /gene="fadE17" FT /locus_tag="Mb1969c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE17" FT /EC_number="1.3.99.-" FT /note="Mb1969c, fadE17, len: 409 aa. Equivalent to Rv1934c, FT len: 409 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 409 aa overlap). Probable fadE17, FT acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to FT ACD_MYCLE|P46703 acyl-CoA dehydrogenase from Mycobacterium FT leprae (389 aa), FASTA scores: opt: 414, E(): 2.6e-19, FT (28.3% identity in 407 aa overlap). Also similar to many FT e.g. NP_249713.1|NC_002516 probable acyl-CoA dehydrogenase FT from Pseudomonas aeruginosa (381 aa); NP_420614.1|NC_002696 FT acyl-CoA dehydrogenase family protein from Caulobacter FT crescentus (355 aa); CAB61610.1|AL133210 putative acyl-CoA FT dehydrogenase from Streptomyces coelicolor (393 aa); etc. FT Also similar to others from Mycobacterium tuberculosis e.g. FT fadE30 (385 aa); fadE31 (377 aa); C-terminus of fadE34 (711 FT aa); etc. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:Q83XB6" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q83XB6" FT /protein_id="CAD94671.1" FT /translation="MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHEREEFARH FT WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLLGIDLLGNTL FT IALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRTRGVLDGDEWVINGHKIWT FT SAGTTANWIFLLARTDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGHSSFSEVFLTDA FT |