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EBI DbfetchID BX248339; SV 1; linear; genomic DNA; STD; PRO; 300050 BP. XX AC BX248339; XX DT 10-JUN-2003 (Rel. 76, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 6/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-300050 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF00380; ykoK. XX FH Key Location/Qualifiers FH FT source 1..300050 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS 165..398 FT /transl_table=11 FT /gene="secG" FT /locus_tag="Mb1475" FT /product="Probable protein-export membrane protein secG" FT /note="Mb1475, secG, len: 77 aa. Equivalent to Rv1440, len: FT 77 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 77 aa overlap). Probable protein-export FT membrane protein secG, similar to many e.g. FT P38388|SECG_MYCLE PROBABLE PROTEIN-EXPORT MEMBRANE (77 aa), FT FASTA scores: opt: 450, E(): 6.7e-24, (96.1% identity in 77 FT aa overlap). Start changed since original submission (-40 FT aa). PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION FT APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, FT SECE|Rv0638, SECF|Rv2586c, SECG AND SECY|Rv0732." FT /db_xref="GOA:P66792" FT /db_xref="InterPro:IPR004692" FT /db_xref="UniProtKB/Swiss-Prot:P66792" FT /protein_id="CAD96142.1" FT /translation="MELALQITLIVTSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSGS FT TVVEKNLDRLTLFVTGIWLVSIIGVALLIKYR" FT CDS complement(537..2012) FT /transl_table=11 FT /gene="PE_PGRS26" FT /locus_tag="Mb1476c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1476c, PE_PGRS26, len: 491 aa. Equivalent to FT Rv1441c, len: 491 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.6% identity in 491 aa overlap). Member of FT the Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, similar to Y0DP_MYCTU|Q50615 FT hypothetical glycine-rich 40.8 kd protein (498 aa), fasta FT scores: opt: 1625, E(): 0, (55.2% identity in 518 aa FT overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U027" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96143.1" FT /translation="MSNVMVVPGMLSAAAADVASIGAALSAANGAAAPTTAGVLAAGAD FT EVSAAIASLFSGYARDYQALSAQMARFHQQFVQALTASVGSYAAAEAANASPLQALEQQ FT VLAAINAPTQTLLGRPLIGNGADGLPGQNGGAGGLLWGNGGNGGAGDAAHPNGGNGGDA FT GMFGNGGAGGAGYSPAAGTGAAGGAGGAGGAGGWLSGNGGAGGNGGTGASGADGGGGLP FT PVPASPGGNGGGGGAGGAAGMFGTGGAGGTGGDGGAGGAGDSPNSGANGARGGDGGNGA FT AGGAGGRLFGNGGAGGNGGTAGQGGDGGTALGAGGIGGDGGTGGAGGTGGTAGIGGSSA FT GAGGAGGDGGAGGNGGGSSMIGGKGGTGGNGGVGGTGGASALTIGNGSSAGAGGAGGAG FT GTGGTGGYIESLDGKGQAGNGGNGGNGAAGGAGGGGTGAGGNGGAGGNGGDGGPSQGGG FT NPGFGGDGGTGGPGGVGVPDGIGGANGAQGKHG" FT CDS 2119..4419 FT /transl_table=11 FT /gene="bisC" FT /locus_tag="Mb1477" FT /product="PROBABLE BIOTIN SULFOXIDE REDUCTASE BISC (BDS FT reductase) (BSO reductase)" FT /EC_number="1.-.-.-" FT /note="Mb1477, bisC, len: 766 aa. Equivalent to Rv1442, FT len: 766 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 766 aa overlap). Probable bisC, Biotin FT sulfoxide reductase (EC 1.-.-.-), similar to FT BISC_ECOLI|P20099 biotin sulfoxide reductase from FT Escherichia coli (739 aa), FASTA scores: opt: 1271, E():0, FT (40.2% identity in 744 aa overlap)." FT /db_xref="GOA:Q7U026" FT /db_xref="HSSP:1EU1" FT /db_xref="InterPro:IPR006658" FT /db_xref="UniProtKB/TrEMBL:Q7U026" FT /protein_id="CAD96144.1" FT /translation="MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGAV FT RHRSRIANPAVRRGWLQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAI FT YGSSYGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAALFEALA FT ETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSVSPLR FT DDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERY FT LLGLDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMA FT ATLAAMLGQIGLPGGGFGHGYSSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQ FT RPGQRLAYNGRLLELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMA FT KHADIVVPTTTSFERDDFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQ FT FTEGRSAREWLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAH FT PLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQPRTRLH FT SQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRP FT KVVQLSTGAWFDPADPRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGE FT LPPVRAHEPPRLA" FT CDS complement(4535..5020) FT /transl_table=11 FT /gene="Mb1478c" FT /locus_tag="Mb1478c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1478c, -, len: 161 aa. Equivalent to Rv1443c, len: FT 161 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 161 aa overlap). Hypothetical unknown protein." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/TrEMBL:Q7U025" FT /protein_id="CAD96145.1" FT /translation="MVGYAEPVLIERQSVVAAPAEQVWQRVVTPEGINDELRPWMTMSV FT PRGAKGMTVDTVPIGAPIGRAWLRLFGVLPFDYDRLSIAELEPGRRFREDSTMLSMRQW FT QHERTVTPEGDTKTIVRDRITFQTRAGLRFAAPLIAAGLRALFGHRHRRLQRHFAQG" FT CDS complement(5634..6044) FT /transl_table=11 FT /gene="Mb1479c" FT /locus_tag="Mb1479c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1479c, -, len: 136 aa. Equivalent to Rv1444c, len: FT 136 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 136 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7U024" FT /protein_id="CAD96146.1" FT /translation="MTVMADRSGRPAPVRRRMKTLTQAALNADKTVEQVEDVLDGLGKT FT MAELNSSLSQLNSTVERLEDGLDHLEGTLHSLDDLAKRLIVLVEPVEAIVDRIDYIVSL FT GETVMSPLSVTEHAVRGVLDRLRNRTVHEPTN" FT CDS complement(6061..6804) FT /transl_table=11 FT /gene="devB" FT /locus_tag="Mb1480c" FT /product="PROBABLE 6-PHOSPHOGLUCONOLACTONASE DEVB (6PGL)" FT /EC_number="3.1.1.31" FT /note="Mb1480c, devB, len: 247 aa. Equivalent to Rv1445c, FT len: 247 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 247 aa overlap). Possible devB (PGL), FT 6-phosphogluconolactonase (EC 3.1.1.31), belongs to a FT different family to the upstream gene zwf2. Similar to e.g. FT DEVB_ANASP|P46016 putative glucose-6-phosphate FT 1-dehydrogenase (239 aa), FASTA scores: opt: 439, E(): FT 2.6e-20, (34.0% identity in 247 aa overlap). BELONGS TO THE FT GLUCOSAMINE/GALACTOSAMINE-6-PHOSPHATE ISOMERASE FAMILY. FT 6-PHOSPHOGLUCONOLACTONASE SUBFAMILY." FT /db_xref="GOA:P63339" FT /db_xref="InterPro:IPR006148" FT /db_xref="UniProtKB/Swiss-Prot:P63339" FT /protein_id="CAD96147.1" FT /translation="MSSSIEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGN FT GIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHP FT MAASDGDFGGDLDAAALAYEQVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAV FT LESTRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSV FT PAAGAVGRQNTLWLLDRDAAAKLPS" FT CDS complement(6801..7712) FT /transl_table=11 FT /gene="opcA" FT /locus_tag="Mb1481c" FT /product="PUTATIVE OXPP CYCLE PROTEIN OPCA" FT /note="Mb1481c, opcA, len: 303 aa. Equivalent to Rv1446c, FT len: 303 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 303 aa overlap). Putative opcA, OxPP FT cycle protein. Highly similar to S72774 B1496_F1_30 protein FT from Mycobacterium leprae (265 aa), FASTA scores: opt: FT 1056, E(): 0, (70.3% identity in 239 aa overlap). Also FT similar to OPCA_NOSS2|P48971 putative oxppcycle protein FT opca from Nostoc punctiforme (465 aa), fasta scores: opt: FT 177, E(): 7.3e-05, (23.4% identity in 321 aa overlap). AIDS FT IN G6PD ACTIVITY." FT /db_xref="InterPro:IPR019297" FT /db_xref="UniProtKB/TrEMBL:Q7U023" FT /protein_id="CAD96148.1" FT /translation="MIVDLPDTTTTAVNKKLDELREKIGAVAMGRVLTLIIAPDSEAML FT EESIEAANDASHEHPSRIIVTMRGDPYADRPRLDAQLRVGADAGAGEFVVLRLSGPLAG FT HADSVVIPFLLPDIPVVAWWPDIAPAVPAQDALGKLAIRRITDATNAIDPLSAIKSRLA FT GYGAGDTDLAWSRITYWRALLTSAVDQPPHEPIESALVSGLKTEPALDVLAGWLASRIE FT GPVRRAVGELKVELVRNSETIVLSRPQEGITATLTRTGKPDALVPLARRVTGECLAEDL FT RRLDPDEIYCAALEGIKKVQYR" FT CDS complement(7765..9309) FT /transl_table=11 FT /gene="zwf2" FT /locus_tag="Mb1482c" FT /product="PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2 FT (G6PD)" FT /EC_number="1.1.1.49" FT /note="Mb1482c, zwf2, len: 514 aa. Equivalent to Rv1447c, FT len: 514 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 514 aa overlap). Probable zwf2 (ZWF), FT Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), highly FT similar to many e.g. G6PD_SYNY3|P73411 Synechocystis sp. FT (509 aa), FASTA scores: opt: 1578, E(): 0, (46.8% identity FT in 509 aa overlap). Also similar to Mycobacterium FT tuberculosis Rv1121, zwf glucose-6-phosphate FT 1-dehydrogenase. Contains PS00069 Glucose-6-phosphate FT dehydrogenase active site. M. tuberculosis has two genes FT for ZWF. This one looks like a classical ZWF. BELONGS TO FT THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY." FT /db_xref="GOA:P0A585" FT /db_xref="HSSP:1QKI" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P0A585" FT /protein_id="CAD96149.1" FT /translation="MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKV FT MPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEG FT FRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLAR FT PQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFA FT NQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEP FT VSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTT FT ETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNA FT MVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEP FT SLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP" FT CDS complement(9306..10427) FT /transl_table=11 FT /gene="tal" FT /locus_tag="Mb1483c" FT /product="PROBABLE TRANSALDOLASE TAL" FT /EC_number="2.2.1.2" FT /note="Mb1483c, tal, len: 373 aa. Equivalent to Rv1448c, FT len: 373 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 373 aa overlap). Probable tal, FT Transaldolase (EC 2.2.1.2), highly similar to many e.g. FT TAL_MYCLE|P55193 transaldolase from Mycobacterium leprae FT (375 aa), FASTA scores: opt: 1891, E(): 0, (78.6% identity FT in 370 aa overlap). BELONGS TO THE TRANSALDOLASE FAMILY." FT /db_xref="GOA:P59955" FT /db_xref="InterPro:IPR014634" FT /db_xref="UniProtKB/Swiss-Prot:P59955" FT /protein_id="CAD96150.1" FT /translation="MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGV FT TTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDG FT VDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGIS FT VNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIG FT SRQALELRGQAGVANARLAYAAYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYS FT DTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGTASDAQAVFDQLGAIGIDLTD FT VFAVLEEEGVRKFEASWNELLQETRAHLDTAAQ" FT CDS complement(10444..12546) FT /transl_table=11 FT /gene="tkt" FT /locus_tag="Mb1484c" FT /product="PROBABLE TRANSKETOLASE TKT (TK)" FT /EC_number="2.2.1.1" FT /note="Mb1484c, tkt, len: 700 aa. Equivalent to Rv1449c, FT len: 700 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 700 aa overlap). Probable tkt, FT Transketolase (EC 2.2.1.1). Highly similar to several e.g. FT TKT_MYCLE|P46708 transketolase (tk) from Mycobacterium FT leprae (699 aa), FASTA scores: opt: 4216, E(): 0, (89.1% FT identity in 700 aa overlap). Start site chosen by homology. FT Contains PS00801 Transketolase signature 1. BELONGS TO THE FT TRANSKETOLASE FAMILY." FT /db_xref="GOA:P59956" FT /db_xref="InterPro:IPR005475" FT /db_xref="UniProtKB/Swiss-Prot:P59956" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96151.1" FT /translation="MTTLEEISALTRPRHPDDWTEIDSAAVDTIRVLAADAVQKVGNGH FT PGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELS FT DIESLRTWGSKTPGHPEFRHTPGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPG FT ASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDRNQISIEDDTNIALCED FT TAARYRAYGWHVQEVEGGENVVGIEEAIANAQAVTDRPSFIALRTVIGYPAPNLMDTGK FT AHGAALGDDEVAAVKKIVGFDPDKTFQVREDVLTHTRGLVARGKQAHERWQLEFDAWAR FT REPERKALLDRLLAQKLPDGWDADLPHWEPGSKALATRAASGAVLSALGPKLPELWGGS FT ADLAGSNNTTIKGADSFGPPSISTKEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTR FT AYGGTFLQFSDYMRPAVRLAALMDIDTIYVWTHDSIGLGEDGPTHQPIEHLSALRAIPR FT LSVVRPADANETAYAWRTILARRNGSGPVGLILTRQGVPVLDGTDAEGVARGGYVLSDA FT GGLQPGEEPDVILIATGSEVQLAVAAQTLLADNDILARVVSMPCLEWFEAQPYEYRDAV FT LPPTVSARVAVEAGVAQCWHQLVGDTGEIVSIEHYGESADHKTLFREYGFTAEAVAAAA FT ERALDN" FT CDS complement(12985..17211) FT /transl_table=11 FT /gene="PE_PGRS27" FT /locus_tag="Mb1485c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1485c, PE_PGRS27, len: 1408 aa. Similar to FT Rv1450c, len: 1329 aa, from Mycobacterium tuberculosis FT strain H37Rv, (92.1% identity in 1417 aa overlap). Member FT of the Mycobacterium tuberculosis PE family, PGRS subfamily FT of gly-rich proteins, similar to Y03A_MYCTU|Q10637 FT hypothetical glycine-rich 49.6 kd protein (603 aa), fasta FT scores: opt: 2112, E(): 0, (56.5% identity in 630 aa FT overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, insertions of 27 bp, 207 bp and 27 bp, substitutions FT of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to FT a longer product compared to the homolog in Mycobacterium FT tuberculosis strain H37Rv (1408 aa versus 1329 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U022" FT /protein_id="CAD96152.1" FT /translation="MSLVIVAPETVAAAALDVARIGSSIGVANSAAAGSTTSVLAAGAD FT EVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHN FT VLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGAGGA FT AGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGV FT GGTGGPGGPGGPGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHG FT GVGGAAGLLGVGGHGGAGGHGAAGIAGAAGKGGIFPDGSNGGAGGDAGDGGTGGRGGWL FT AGAGGAGGDGGIGGTGGAGGAGFSRALIVAGDNGGDGGNGGMGGAGGAGGPGGAGGLIS FT LLGGQGAGGDGGDGGAGGVGGDRGAGANGNQAVNAGAGGAGGHGGDPGAGGAGGTGGAG FT STIGAHGAAGASPTSGGNGGAGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGAGGAGGNG FT APGAPPSGGDPNGGGGGAGGAGGKGGDGGAQAGDGGAGGAGGKGGNGGNGATGATGLNG FT LGAGADGTDGGKGGNGGAGGGGGAGGQGGKALAATHQDGSMGAGGAGGNGGAGGMGGDG FT GNGAKGTFDNGGDGVGGNGGNGGSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTG FT GNGANATVAGGAGGAGGKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNG FT GAGGAGGAGGRGGDFGGDGGTGGAGGNGADGGAGGNGANGANATTPGAKGGDGGHGGPG FT AQGGNGGQGGPGGLAGNLFGQNGIQGVGGSGGKGGAGGLAGDGGNGANGNFAFGDGNGG FT HGGNGGNPGAGGQGGSGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGHSQVVGGNGGDGG FT NGGNGGSAGTGGNGGRGGDGAFGGMSANATNPGENGPNGNPGGNGGAGGAGGAGLNGGN FT GGAGGNGGLGGFGGNGAAGANGVAVGAPGQPGGAGGHGGAGGNGGAGGNGGQGVVSDGA FT GGAGGAGGDGGAPGDGANGGNGQGAGAFAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGK FT AGPAGSILHDGGNGGHGGHGAASGGNGGPGGHGGNGGNGGTGANGGNGGIGGTGGAGST FT GAKGVLGTNEGDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGGTPGNGGNGGNGASGDL FT VTSPGDGGGGGRGGDAGRGGDAGLGGSSGPGGTPGDWGTGGTGGTGGTGGQGANGGLTG FT GRGGTGGNGGAGGTGGTGHNGSQPGMGGNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTG FT DAGPFGTGTGGTGGHGGQGGGGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGL FT GGGEFV" FT CDS 17613..18539 FT /transl_table=11 FT /gene="ctaB" FT /locus_tag="Mb1486" FT /product="PROBABLE CYTOCHROME C OXIDASE ASSEMBLY FACTOR FT CTAB" FT /note="Mb1486, ctaB, len: 308 aa. Equivalent to Rv1451, FT len: 308 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 308 aa overlap). Probable ctaB, FT cytochrome C oxidase assembly factor, and integral membrane FT protein. Highly similar to several Mycobacterium leprae FT proteins e.g. Q49685 CYOE cytochrome O ubiquinol oxidase FT assembly factor (300 aa), FASTA scores: opt: 1636, E(): 0, FT (82.7% identity in 307 aa overlap); NP_301495.1|NC_002677 FT putative protoheme IX farnesyltransferase (321 aa); FT NP_301495.1|NC_002677 putative protoheme IX FT farnesyltransferase (321 aa)." FT /db_xref="GOA:Q7U021" FT /db_xref="InterPro:IPR000537" FT /db_xref="UniProtKB/Swiss-Prot:Q7U021" FT /protein_id="CAD96153.1" FT /translation="MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLL FT ADRGAIHPLLMLNTLVGGMMAATGANTLNCVADADIDKVMKRTARRPLAREAVPTRNAL FT ALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMP FT VMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQV FT TKQILIYTWLTVAATLVLALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRL FT FLQSNNYLAVVFCALAVDSVIALPTLH" FT CDS complement(18588..20975) FT /transl_table=11 FT /gene="PE_PGRS28" FT /locus_tag="Mb1487c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1487c, PE_PGRS28, len: 795 aa. Highly similar to FT Rv1452c, len: 741 aa, from Mycobacterium tuberculosis FT strain H37Rv, (89.1% identity in 795 aa overlap). Member of FT the Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, similar to Y03A_MYCTU|Q10637 FT hypothetical glycine-rich 49.6 kd protein (603 aa), fasta FT scores: opt: 2090, E(): 0, (56.3% identity in 641 aa FT overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, substitutions of 3 bp to 144 bp, 40 bp to 49 bp, 31 FT bp to 31 bp, 4 bp to 4 bp (gggc-ttgg), 12 bp to 12 bp, 11 FT bp to 11 bp, 60 bp to 63 bp, 13 bp to 13 bp and 2 bp to 2 FT bp (tt-cc), and a 9 bp insertion (*-cccgccggc), leads to a FT longer product compared to the homolog in Mycobacterium FT tuberculosis strain H37Rv (795 aa versus 741 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U020" FT /protein_id="CAD96154.1" FT /translation="MSLVIVAPETVAAAALDVARIGSSIGVANSAAAGSTTSVLAAGAD FT EVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHN FT VLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGAGGA FT AGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGV FT GGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGGAAGLL FT GVGGHGGAGGHGAAGIAGAAGKGGIFPDGSNGGAGGDAGDGGTGGRGGWLAGAGGAGGD FT GGIGGTGGAGGAGFSRALIVAGDNGGDGGNGGMGGAGGAGGPGGAGGLISLLGGQGAGG FT DGGDGGAGGVGGDRGAGANGNQAVNAGAGGAGGHGGDPGAGGAGGTGGAGSTIGAHGAA FT GASPTSGGNGGAGGNGAHFSSGGKAGGNGGAGGAGGHGGLVGNGGAGGAGGNGANGAAG FT TNASDSGAVGGKGNSGGNGGQGGAGGDGGTLAGNGGAGGTGGRGADGGLGGSGAEGANA FT TTAGERGQDGGKGGNGGVGGTGGNAVAPGANGGHGGNGGNPGFSGAGGLGGLSGDGVTR FT AAQGATPDFADTGGKGGNGGNGANAVAPGGTGASGGAGGNAGAGGKGGENIIGDGGGGG FT NGGAGGQGGDGTAGAGGDGGAGGKGGDGGDGGSDPTEGRGFGGLGGAGGAGGKGGAGTL FT LGLTVFGDNGGAGVLGDSTDPDGSGGAGGAGGAGGAGGDPTI" FT CDS 21127..22392 FT /transl_table=11 FT /gene="Mb1488" FT /locus_tag="Mb1488" FT /product="POSSIBLE TRANSCRIPTIONAL ACTIVATOR PROTEIN" FT /note="Mb1488, -, len: 421 aa. Equivalent to Rv1453, len: FT 421 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 421 aa overlap). Possible FT transcriptional activator, similar to Q50018 putative FT transcriptional activator trx from Mycobacterium leprae FT (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity FT in 500 aa overlap). Also highly similar to Mycobacterium FT tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c, FT and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% FT identity in 335 aa overlap). Start changed since first FT submission (-11 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U019" FT /protein_id="CAD96155.1" FT /translation="MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAA FT DPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALDIY FT RIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERDKLT FT RDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLDRVAD FT AFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIEG FT FRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASP FT ALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQ FT QWREKQTSDPPAKKESNGTKMR" FT CDS complement(22420..23406) FT /transl_table=11 FT /gene="qor" FT /locus_tag="Mb1489c" FT /product="PROBABLE QUINONE REDUCTASE QOR (NADPH:quinone FT reductase) (Zeta-crystallin homolog protein)" FT /EC_number="1.6.5.5" FT /note="Mb1489c, qor, len: 328 aa. Equivalent to Rv1454c, FT len: 328 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 328 aa overlap). Probable qor, quinone FT oxidoreductase (EC 1.6.5.5), simiar to U87282|RCU87282_2 FT quinone oxidoreductase from Rhodobacter capsulatus (323 FT aa), FASTA scores: opt: 849, E(): 0, (44.7% identity in 329 FT aa overlap). Also similar to MTCY180.06 Hypothetical FT protein from Mycobacterium tuberculosis (334 aa), FASTA FT scores: opt: 430, E(): 2e-14, (32.3% identity in 350 aa FT overlap). Contains PS01162 Quinone oxidoreductase / FT zeta-crystallin signature." FT /db_xref="GOA:Q7U018" FT /db_xref="HSSP:1IYZ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U018" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96156.1" FT /translation="MHAIEVTETGGPGVLRHVDQPQPQPGHGELLIKAEAIGVNFIDTY FT FRSGQYPRELPFVIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASANGAYAEFCTAPA FT SLTAKVPDDVTSEVAASALLKGLTAHYLLKSVYPVKRGDTVLVHAGAGGVGLILTQWAT FT HLGVRVITTVSTAEKAKLSKDAGADVVLDYPEDAWQFAGRVRELTGGTGVQAVYDGVGA FT TTFDASLASLAVRGTLALFGAASGPVPPVDPQRLNAAGSVYLTRPSLFHFTRTGEEFSW FT RAAELFDAIGSEAITVAVGGRYPLADALRAHQDLEARKTVGSVVLLP" FT CDS 23426..24289 FT /transl_table=11 FT /gene="Mb1490" FT /locus_tag="Mb1490" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1490, -, len: 287 aa. Equivalent to Rv1455, len: FT 287 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 287 aa overlap). Conserved hypothetical FT protein, some similarity from aa 80-160 to FT Z99125|MLCL536.35c hypothetical Mycobacterium leprae FT protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, FT (51.3% identity in 78 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U017" FT /protein_id="CAD96157.1" FT /translation="MKLARPDVFHPRVVLAGWPQQPAGDGDDAGLVAALRHRGLHAGWL FT SWDDPEIVHADLVILRATRDYPARLDEFLAWTTRVANLLNSRPVVAWNVERRYLRDLMD FT RGVPTVPGEVYVPGEPVRLPRKGQVFVGPTIGTGTRRCSARFAAEFVAQLHAAGQAVLV FT QPGGSGDETVLVFLGGEPSHAFTKQADTWRQTEPDFEIWDVGAAAVAGAAAQVGVDPGE FT LLYARAHITGGSRDPRLLELQLVDPSLGWQWLDPDIRNLAQRDFALCVQSALERLGLGP FT FSHRRP" FT CDS complement(24239..25171) FT /transl_table=11 FT /gene="Mb1491c" FT /locus_tag="Mb1491c" FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT FT INTEGRAL MEMBRANE ABC TRANSPORTER" FT /note="Mb1491c, -, len: 310 aa. Equivalent to Rv1456c, len: FT 310 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 310 aa overlap). Possible unidentified FT antibiotic-transport integral membrane protein ABC FT transporter (see citation below), equivalent to FT Z99125|MLCL536.34 from Mycobacterium leprae (311 aa), FASTA FT scores: opt: 1607, E(): 0, (83.3% identity in 300 aa FT overlap)." FT /db_xref="GOA:Q7U016" FT /db_xref="InterPro:IPR003780" FT /db_xref="UniProtKB/TrEMBL:Q7U016" FT /protein_id="CAD96158.1" FT /translation="MPYDRAVSPSLRVQRVIAAIVILTQGGIAVTGAIVRVTASGLGCP FT TWPQCFPGSFTPVVVAEVPRVHQAVEFGNRMVTFAVVIAAALAVLVVTRARRRTEVLAY FT AWLMPVSTVVQAMIGGITVRTGLLWWTVAIHLLASMTMVWLAVLLYVKIGQPDDGVVHE FT LVVSPLRALTALSALNLAAVLVTGTLVTAAGPHAGDRSPSRTVPRLKVEITTLVHMHSS FT LLVAYLALLIGLGFGLLAVGATRAILVRLAVLLALVATQAAVGTTQYFTGVPAALVAIH FT VAGAAAVTAATAALWASMGERAQPQPLQR" FT CDS complement(25283..26068) FT /transl_table=11 FT /gene="Mb1492c" FT /locus_tag="Mb1492c" FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT FT INTEGRAL MEMBRANE ABC TRANSPORTER" FT /note="Mb1492c, -, len: 261 aa. Equivalent to Rv1457c, len: FT 261 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 261 aa overlap). Possible unidentified FT antibiotic-transport integral membrane protein ABC FT transporter (see citation below), equivalent to FT Z99125|MLCL536.32 from Mycobacterium leprae (265 aa), FASTA FT scores: opt: 1415, E(): 0, (83.1% identity in 260 aa FT overlap)." FT /db_xref="GOA:Q7U015" FT /db_xref="InterPro:IPR004377" FT /db_xref="UniProtKB/TrEMBL:Q7U015" FT /protein_id="CAD96159.1" FT /translation="MTQTNRPAFPAGTFSPDPRPNAVPLMLAAQFSLELKLLLRNGEQL FT LLTMFIPITLLVGLTLLPMGSFGHNRAATFVPVIMALAVISTAFTGQAIAVAFDRRYGA FT LKRLGATPLPVWGIIAGKSLAVVAVVFLQAIILGAIGFALGWRPALTALTLGAGIIALG FT TAGFAALGLLLGGTLRAEIVLAVANLMWFVFAGFGALTLESNVIPTAFKWVARVTPSGA FT LTEALSQAMTVSVDWFGIVVLAVWGALAALAALRWFRFT" FT CDS complement(26065..27006) FT /transl_table=11 FT /gene="Mb1493c" FT /locus_tag="Mb1493c" FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /note="Mb1493c, -, len: 313 aa. Equivalent to Rv1458c, len: FT 313 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 313 aa overlap). Possible unidentified FT antibiotic-transport ATP-binding protein ABC transporter FT (see citation below), equivalent to Z99125|MLCL536.31 from FT Mycobacterium leprae (315 aa), FASTA scores: opt: 1812, FT E(): 0, (88.0% identity in 308 aa overlap). Similar to FT AF027770|AF027770_7 ABC-type transporter in FxbA region in FT Mycobacterium smegmatis (284 aa), FASTA scores: opt: 1412, FT E(): 0, (85.1% identity in 248 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 FT ABC transporters family signature. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7U014" FT /db_xref="HSSP:1JI0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U014" FT /protein_id="CAD96160.1" FT /translation="MNRAPDTPEVVLRLRGVCKRYGSITAVSNLDLDVHDAEVMALLGP FT NGAGKTTTVEMCEGFVRPDAGSIEVLGLDPITDNARLRARIGVMLQGGGGYPAARAGEM FT LDLVASYAANPLDPHWLLDTLGLTEAARTTYRRLSGGQQQRLALACALVGRPQLVFLDE FT PTAGMDAHARVLVWELIDALRRDGVTVVLTTHHLKEAEELADRLVIIDHGVTVAAGTPA FT ELMRSGAKDQLRFTAPPRLDLSLLASALPEGYQATELTPGEYLVEGPVDPQVLATVTAW FT CAQIDVLATDMRVEQRSLEDVFLDLTGRKLRQ" FT CDS complement(27109..28884) FT /transl_table=11 FT /gene="Mb1494c" FT /locus_tag="Mb1494c" FT /product="POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb1494c, -, len: 591 aa. Equivalent to Rv1459c, len: FT 591 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 591 aa overlap). Possible conserved FT integral membrane protein, equivalent to MLCL536.30|Z99125 FT hypothetical protein from Mycobacterium leprae (593 aa), FT FASTA scores: opt: 1670, E(): 0, (78.6% identity in 585 aa FT overlap). Also similar to Mycobacterium tuberculosis FT protein Rv2174|MTV021.07 (33.1% identity in 523 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U013" FT /protein_id="CAD96161.1" FT /translation="MAARHHTLSWSIASLHGDEQAVGAPLTTTELTALARTRLFGATGT FT VLMAIGALGAGARPVVQDPTFGVRLLNLPSRIQTVSLTMTTTGAVMMALAWLMLGRFTL FT GRRRMSRGELDRTLLLWMLPLLIAPPMYSKDVYSYLAQSEIGRDGLDPYRVGPASGLGL FT GHVFTLSVPSLWRETPAPYGPLFLWIGRGISSLTGENIVAAVLCHRLVVLIGVTLIVWA FT TPRLAQRCGVAEVSALWLGAANPLLIMHLVAGIHNEALMLGLMLTGVEFALRGLDMANT FT PRPSPETWRLGPATIRASRRPELGASPRAGASRAVKPRPEWGPLAMLLAGSILITLSSQ FT VKLPSLLAMGFVTTVLAYRWGGNLRALLLAAAVMASLTLAIMAILGWASGLGFGWINTL FT GTANVVRSWMSPPTLLALGTGHVGILLGLGDHTTAVLSLTRAIGVLIITVMVCWLLLAV FT LRGRLHPIGGLGVALAVTVLLFPVVQPWYLLWAIIPLAAWATRPGFRVAAILATLIVGI FT FGPTANGDRFALFQIVDATAASAIIVILLIALTYTRLPWRPLAAEQVVTAAESASKTPA FT TRRPTAAPDAYADST" FT CDS 28932..29738 FT /transl_table=11 FT /gene="Mb1495" FT /locus_tag="Mb1495" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1495, -, len: 268 aa. Equivalent to Rv1460, len: FT 268 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 268 aa overlap). Probable FT transcriptional regulatory protein. Equivalent to FT Z99125|MLCL536.29c hypothetical protein from Mycobacterium FT leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% FT identity in 250 aa overlap). Possible helix-turn-helix FT motif between aa 68 - 89. Start changed since original FT submission." FT /db_xref="InterPro:IPR013196" FT /db_xref="UniProtKB/TrEMBL:Q7U012" FT /protein_id="CAD96162.1" FT /translation="MTSTTLPHRASLVDRSTEFCHTDVVKIPAVSTTVPAAVSDGHTRR FT AIVRLLLESGSITAGEIGDRLGLSAAGVRRHLDALIEAGDAEASAAAPWQQVGRGRPAK FT RYRLTAAGRAKLDHSYDDLASAAMRQLREIGGEEAVRTFARRRIDAILADVAPADGPDD FT AALEAAAERIATALSKAGYVATTTRVGGPIHGVQICQHHCPVSHVAEEFPELCETEQQA FT MAEVLGTHVQRLATIVNGDCACTTHVPLSPAPSPRPPATSTEGVSR" FT CDS 29735..32275 FT /transl_table=11 FT /gene="Mb1496" FT /locus_tag="Mb1496" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1496, -, len: 846 aa. Equivalent to Rv1461, len: FT 846 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 846 aa overlap). Conserved hypothetical FT protein. Equivalent of spliced protein from Mycobacterium FT leprae MLCL536.28c len: 869. Residues 1-253 represent FT N-extein, and 613-846 the C-extein. The intein present from FT residues 254 - 612 is different in sequence and site of the FT insertion from the one present in MLCL536.28c. FASTA FT scores: Z99125|MLCL536_23 Mycobacterium leprae cosmid L536 FT (869 aa), opt: 1498 E(): 0, (54.1% identity in 917 aa FT overlap). The mature protein is similar to FT Z99120|BSUB0017_150 hypothetical Bacillus subtilis protein FT (465 aa), FASTA scores: opt:1053, E(): 0, (34.8% identity FT in 821 aa overlap). The intein shows some similarity to FT inteins from U67548|MJU67548_6 Methanococcus jannaschii FT (895 aa), FASTA scores: opt: 181, E(): 0.00023, (25.2% FT identity in 274 aa overlap)." FT /db_xref="GOA:P67126" FT /db_xref="HSSP:1LWT" FT /db_xref="InterPro:IPR000825" FT /db_xref="UniProtKB/Swiss-Prot:P67126" FT /protein_id="CAD96163.1" FT /translation="MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGAN FT AQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVR FT STEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGV FT IFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQA FT YFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTG FT HDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWK FT AEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHAC FT LTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAM FT RDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAF FT QLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFA FT VPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHA FT RVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEV FT LSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSS FT VKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFYLMSRGLTEDEAMAM FT VVRGFVEPIAKELPMEYALELNRLIELQMEGAVG" FT CDS 32272..33465 FT /transl_table=11 FT /gene="Mb1497" FT /locus_tag="Mb1497" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1497, -, len: 397 aa. Equivalent to Rv1462, len: FT 397 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 397 aa overlap). Conserved hypothetical FT protein. Equivalent to MLCL536.27c|Z99125 hypothetical FT protein from Mycobacterium leprae (392 aa), FASTA scores: FT opt: 2059, E(): 0, (80.4% identity in 392 aa overlap). Also FT similar to nearby Mycobacterium tuberculosis hypothetical FT protein Rv1461." FT /db_xref="GOA:P59973" FT /db_xref="InterPro:IPR011542" FT /db_xref="UniProtKB/Swiss-Prot:P59973" FT /protein_id="CAD96164.1" FT /translation="MTAPGLTAAVEGIAHNKGELFASFDVDAFEVPHGRDEIWRFTPLR FT RLRGLHDGSARATGSATITVSERPGVYTQTVRRGDPRLGEGGVPTDRVAAQAFSSFNSA FT TLVTVERDTQVVEPVGITVTGPGEGAVAYGHLQVRIEELGEAVVVIDHRGGGTYADNVE FT FVVDDAARLTAVWIADWADDTVHLSAHHARIGKDAVLRHVTVMLGGDVVRMSAGVRFCG FT AGGDAELLGLYFADDGQHLESRLLVDHAHPDCKSNVLYKGALQGDPASSLPDAHTVWVG FT DVLIRAQATGTDTFEVNRNLVLTDGARADSVPNLEIETGEIVGAGHASATGRFDDEQLF FT YLRSRGIPEAQARRLVVRGFFGEIIAKIAVPEVRERLTAAIEHELEITESTEKTTVS" FT CDS 33462..34262 FT /transl_table=11 FT /gene="Mb1498" FT /locus_tag="Mb1498" FT /product="PROBABLE CONSERVED ATP-BINDING PROTEIN ABC FT TRANSPORTER" FT /note="Mb1498, -, len: 266 aa. Equivalent to Rv1463, len: FT 266 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 266 aa overlap). Probable conserved ATP-binding FT protein ABC transporter, equivalent to Z99125|MLCL536.26c FT putative ABC transporter ATP-binding protein from FT Mycobacterium leprae (260 aa), FASTA scores: opt: 1444, FT E(): 0, (86.0% identity in 267 aa overlap). Very similar to FT U38804|PPU38804_55 ATP-DEPENDENT TRANSPORTER YCF16 from FT PORPHYRA PURPUREA chloroplast (251 aa), FASTA scores: opt: FT 822, E(): 0, (52.4% identity in 248 aa overlap); and FT similar to others. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT FT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7U011" FT /db_xref="InterPro:IPR010230" FT /db_xref="UniProtKB/TrEMBL:Q7U011" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96165.1" FT /translation="MTILEIKDLHVSVENPAEADHEIPILRGVDLTVKSGETHALMGPN FT GSGKSTLSYAIAGHPKYHVTSGTITLDGADVLAMSIDERARAGLFLAMQYPVEVPGVSM FT SNFLRSAATAIRGEPPKLRHWVKEVKAAMAALDIDPAFAERSVNEGFSGGEKKRHEILQ FT LELLKPKIAILDETDSGLDVDALRVVSEGVNRYAESQHGGILLITHYTRILRYIHPEYV FT HVFVGGRIVESGGSELADELDQNGYVRFSPASGRYPHQPAPTGA" FT CDS 34264..35517 FT /transl_table=11 FT /gene="csd" FT /locus_tag="Mb1499" FT /product="PROBABLE CYSTEINE DESULFURASE CSD" FT /EC_number="4.4.1.-" FT /note="Mb1499, csd, len: 417 aa. Equivalent to Rv1464, len: FT 417 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 417 aa overlap). Probable csd, cysteine FT desulfurase (EC 4.4.1.- ). Equivalent to Q49690|MLCL536.25C FT cysteine desulfurase from Mycobacterium leprae (418 aa), FT FASTA scores: opt: 2333, E(): 0, (85.4% identity in 417 aa FT overlap); and similar to cysteine desulfurase from other FT organisms. Also similar to M. tuberculosis proteins FT Rv3025c|ISCS and Rv3778c. Contains PS00595 FT Aminotransferases class-V pyridoxal-phosphate attachment FT site. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES. CSD SUBFAMILY." FT /db_xref="GOA:P63517" FT /db_xref="HSSP:1C0N" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P63517" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96166.1" FT /translation="MTASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQV FT LDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTKNATEALN FT LVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGRIDL FT DSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHEL FT GVDFAAFSGHKMLGPNGIGVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFE FT AGTPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDR FT GSPVAFVVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADE FT VDRLVAGVRRSRHFFGRA" FT CDS 35514..36002 FT /transl_table=11 FT /gene="Mb1500" FT /locus_tag="Mb1500" FT /product="POSSIBLE NITROGEN FIXATION RELATED PROTEIN" FT /note="Mb1500, -, len: 162 aa. Equivalent to Rv1465, len: FT 162 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 162 aa overlap). Possible nitrogen fixation FT related protein. Equivalent to Z99125|MLCL536.24c nitrogen FT fixation protein NIFU from Mycobacterium leprae (165 aa), FT FASTA scores: opt: 870, E(): 0, (81.8% identity in 165 aa FT overlap). Also similar to O32163|Z99120|NIFU_BACSU FT NifU-like protein from Bacillus subtilis (147 aa), FASTA FT scores: opt: 354, E(): 4.1e-17, (38.3% identity in 141 aa FT overlap) and to AL096839|SCC22.02 hypothetical protein from FT Streptomyces coelicolor (156 aa), FASTA scores: opt: 569, FT E(): 1.2e-31, (56.3% identity in 158 aa overlap)." FT /db_xref="GOA:Q7U010" FT /db_xref="InterPro:IPR002871" FT /db_xref="UniProtKB/TrEMBL:Q7U010" FT /protein_id="CAD96167.1" FT /translation="MTLRLEQIYQDVILDHYKHPQHRGLREPFGAQVYHVNPICGDEVT FT LRVALSEDGTRVTDVSYDGQGCSISQAATSVLTEQVIGQRVPRALNIVDAFTEMVSSRG FT TVPGDEDVLGDGVAFAGVAKYPARVKCALLGWMAFKDALAQASEAFEEVTDERNQRTG" FT CDS 35977..36324 FT /transl_table=11 FT /gene="Mb1501" FT /locus_tag="Mb1501" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1501, -, len: 115 aa. Equivalent to Rv1466, len: FT 115 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 115 aa overlap). Conserved hypothetical FT protein. Equivalent to Z99125|MLCL536.23c hypothetical FT protein from Mycobacterium leprae (115 aa), FASTA scores: FT opt: 648, E(): 0, (81.7% identity in 115 aa overlap). FT Similar to ORF's downstream of sigma factors in FT Streptococcus mutans and Streptococcus pneumoniae e.g. FT O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa). FT Alternative TTG start possible at 13757 then avoids overlap FT with MTV007.12." FT /db_xref="InterPro:IPR002744" FT /db_xref="UniProtKB/TrEMBL:Q7U009" FT /protein_id="CAD96168.1" FT /translation="MSETSAPAEELLADVEEAMRDVVDPELGINVVDLGLVYGLDVQDG FT DEGTVALIDMTLTSAACPLTDVIEDQSRSALVGSGLVDDIRINWVWNPPWGPDKITEDG FT REQLRALGFTV" FT CDS complement(36419..38248) FT /transl_table=11 FT /gene="fadE15" FT /locus_tag="Mb1502c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE15" FT /EC_number="1.3.99.-" FT /note="Mb1502c, fadE15, len: 609 aa. Equivalent to Rv1467c, FT len: 609 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 609 aa overlap). Probable fadE15, FT acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to FT NP_302639.1|NC_002677 acyl-CoA dehydrogenase from FT Mycobacterium leprae (611 aa). Also highly similar to many FT e.g. T36481 probable acyl-CoA dehydrogenase (fragment) from FT Streptomyces coelicolor (491 aa) (has its N-terminus very FT shorter); NP_384640.1|NC_003047 PUTATIVE ACYL-COA FT DEHYDROGENASE PROTEIN from Sinorhizobium meliloti (598 aa); FT ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain FT specific) from Megasphaera elsdenii (383 aa), FASTA scores: FT E(): 2e-12, (25.4% identity in 410 aa overlap); etc. Also FT highly similar to fadE5|Rv0244c|MTV034.10c ACYL-COA FT DEHYDROGENASE from M. tuberculosis (611 aa); and similar to FT other proteins from Mycobacterium tuberculosis." FT /db_xref="GOA:Q7U008" FT /db_xref="InterPro:IPR006091" FT /db_xref="UniProtKB/TrEMBL:Q7U008" FT /protein_id="CAD96169.1" FT /translation="MGHYIANVRDLEFNLLEVLDIGAVLGTGRYSDLDVDTVRTILAEA FT ARLAEGPIAESFGYADRNPPVFDPNTHSISVPDELAKTVQAIKEAGWWRLGLAEEIGGM FT PAPPPLAWAVNEMIYCANPSACFFNLGPVLAQSLYIEGNDEQRRWAAEGVQRGWQATMV FT LTEPDAGSDVGAGRTKAFEQPDGTWHIEGVKRFISGGDVGNTAENIFHLVLARPEGAGP FT GTKGLSLFYVPNYLFDPDTFELGARNGVYVTGLEHKMGLKSSPTCELTFGGADVPAVGY FT LVGGVHNGIAQMFTVIEHARMTIGVKSAGTLSTGYLNALAFAKERVQGADLTQMTDKTA FT PRVTIMHHPDVRRSLMTQKAYAEGLRALYLYAAAHQDDAVAQRVSGADHDMAHRVDDLL FT LPIVKGVGSERAYEILTESLQTLGGSGFLVDYPLEQYIRDAKIDSLYEGTTAIQALDFF FT FRKIVRDHGKALQFVLAQVTHTVENIDPSLKPQAELLRTALDDITAMTGALTGYLMSAA FT QHSSDIYKVGLGSVRYLLAVGDLLIGWRLLVLAGVAHAALADGPSQNDEAFYRGKIAVA FT AFFAKNMLPKLTGVRSVIENIDDDIMRVPEDAF" FT CDS complement(38355..39467) FT /transl_table=11 FT /gene="PE_PGRS29" FT /locus_tag="Mb1503c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1503c, PE_PGRS29, len: 370 aa. Equivalent to FT Rv1468c, len: 370 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 370 aa overlap). Member of FT the Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U007" FT /protein_id="CAD96170.1" FT /translation="MSFVVANTEFVSGAAGNLARLGSMISAANSAAAAQTTAVAAAGAD FT EVSAAVAALFGAHGQTYQVLSAQAAAFHSQFVQALSGGAQAYAAAEATNFGPLQPLFDV FT INAPTLALLNRPLIGNGADGTAANPNGQAGGLLIGNGGNGFSPAAGPGGNGGAAGLLGH FT GGNGGVGALGANGGAGGTGGWLFGNGGAGGNSGGGGGAGGIGGSAVLFGAGGAGGISPN FT GMGAGGSGGNGGLFFGNGGAGASSFLGGGGAGGRAFLFGDGGAGGAALSAGSAGRGGDA FT GFFYGNGGAGGSGAGGASSAHGGAGGQAGLFGNGGEGGDGGALGGNGGNGGNAQLIGNG FT GDGGDGGGAGAPGLGGRGGLLLGLPGANGT" FT CDS 39709..41682 FT /transl_table=11 FT /gene="ctpD" FT /locus_tag="Mb1504" FT /product="PROBABLE CATION TRANSPORTER P-TYPE ATPASE D CTPD" FT /EC_number="3.6.3.-" FT /note="Mb1504, ctpD, len: 657 aa. Equivalent to Rv1469, FT len: 657 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 657 aa overlap). Probable ctpD, FT cation-transporting P-type ATPase D (transmembrane protein) FT (EC 3.6.3.-), highly similar to others e.g. T35947 probable FT cation-transporting ATPase from Streptomyces coelicolor FT (638 aa); NP_442633.1|NC_000911 cation-transporting ATPase FT (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (642 FT aa), FASTA scores: opt: 1438, E(): 0, (41.9% identity in FT 592 aa overlap); NP_389268.1|NC_000964 protein similar to FT heavy metal-transporting ATPase from Bacillus subtilis (637 FT aa); etc. Also highly similar to others from Mycobacterium FT tuberculosis e.g. Rv3743c|MTV025.091c|CTPJ (660 aa). FT Contains PS00154 E1-E2 ATPases phosphorylation site. FT BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 FT ATPASES), SUBFAMILY IB." FT /db_xref="GOA:P63686" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:P63686" FT /protein_id="CAD96171.1" FT /translation="MTLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVAL FT LLFLAGLVAQLNGAPEAMWWTLYLACYLAGGWGSAWAGAQALRNKALDVDLLMIAAAVG FT AVAIGQIFDGALLIVIFATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSERVVA FT ASELVVGDRVVVRPGDRIPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGS FT GVLHLVVTRDPSQTVVARIVELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIP FT LMFGADLRPVLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVVERLAD FT TSIVALDKTGTLTRGIPRLASVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEAR FT RRGIAIPPAKDFRAVPGCGVHALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVL FT LDGVAIGVLGLTDQLRPDAVESVAAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRA FT ALLPEQKVEVVRNLQAGGHQVLLVGDGVNDAPAMAAARAAVAMGAGADLTLQTADGVTI FT RDELHTIPTIIGLARQARRVVTVNLAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVL FT VALNGMRLLTNRSWRAAASAAR" FT CDS 41726..42100 FT /transl_table=11 FT /gene="trxA" FT /locus_tag="Mb1505" FT /product="PROBABLE THIOREDOXIN TRXA" FT /EC_number="1.-.-.-" FT /note="Mb1505, trxA, len: 124 aa. Equivalent to Rv1470, FT len: 124 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 124 aa overlap). Probable trxA, FT thioredoxin (EC 1.-.-.-), similar to many e.g. FT P12243|THI1_SYNP7 THIOREDOXIN 1 from Synechococcus sp. (106 FT aa), FASTA scores: opt: 201, E(): 9.2e-08, (35.4% identity FT in 99 aa overlap); etc. Highly similar to downstream ORF FT Rv1471|trxB1 probable thioredoxin from M. tuberculosis (123 FT aa), FASTA scores: opt: 402, E(): 0, (54.4% identity in 114 FT aa overlap). Warning: note that FT Rv3914|MT4033|MTV028.05|trxC can be alternatively named FT trxA." FT /db_xref="GOA:Q7U006" FT /db_xref="InterPro:IPR013766" FT /db_xref="UniProtKB/TrEMBL:Q7U006" FT /protein_id="CAD96172.1" FT /translation="MTTRDLTAAYFQQTISANSNVLVYFWAPLCAPCDLFTPTYEASSR FT KHFDVVHGKVNIETEKDLASIAGVKLLPTLMAFKKGKLVFKQAGIANPAIMDNLVQQLR FT AYTFKSPAGEGIGPGTKTSS" FT CDS 42116..42487 FT /transl_table=11 FT /gene="trxB1" FT /locus_tag="Mb1506" FT /standard_name="trxB" FT /product="PROBABLE THIOREDOXIN TRXB1" FT /EC_number="1.-.-.-" FT /note="Mb1506, trxB1, len: 123 aa. Equivalent to Rv1471, FT len: 123 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 123 aa overlap). Probable trxB1, FT thioredoxin (EC 1.-.-.-), similar to many bacterial FT thioredoxins e.g. P33636|THI2_ECOLI from Escherichia coli FT (139 aa), FASTA scores: opt: 290, E(): 1.8e-13, (44.3% FT identity in 97 aa overlap); etc. Highly similar to FT Rv1470|TrxA probable thioredoxin from Mycobacterium FT tuberculosis (124 aa), FASTA scores: opt: 402, E(): FT 1.2e-32, (54.4% identity in 114 aa overlap). Contains FT PS00194 Thioredoxin family active site. BELONGS TO THE FT THIOREDOXIN FAMILY. Note that previously known as trxB." FT /db_xref="GOA:Q7U005" FT /db_xref="HSSP:1DBY" FT /db_xref="InterPro:IPR013766" FT /db_xref="UniProtKB/TrEMBL:Q7U005" FT /protein_id="CAD96173.1" FT /translation="MTTRDLTAAQFNETIQSSDMVLVDYWASWCGPCRAFAPTFAESSE FT KHPDVVHAKVDTEAERELAAAAQIRSIPTIMAFKNGKLLFNQAGALPPAALESLVQQLK FT AYEVEAGEATTQNGRAQQA" FT CDS 42509..43366 FT /transl_table=11 FT /gene="echA12" FT /locus_tag="Mb1507" FT /product="POSSIBLE ENOYL-CoA HYDRATASE ECHA12 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /EC_number="4.2.1.17" FT /note="Mb1507, echA12, len: 285 aa. Equivalent to Rv1472, FT len: 285 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 285 aa overlap). Possible echA12, FT enoyl-CoA hydratase (EC 4.2.1.17), highly similar to FT P53526|ECHH_MYCLE|NP_301896.1|NC_002677 possible enoyl-CoA FT hydratase/isomerase from Mycobacterium leprae (294 aa), FT FASTA scores: opt: 1265, E(): 0, (72.0% identity in 271 aa FT overlap). Also similar to others e.g. CAA66096.1|X97452 FT enoyl-CoA isomerase from Escherichia coli strain K12 (262 FT aa); CAC44593.1|AL596162 putative enoyl-CoA hydratase from FT Streptomyces coelicolor (275 aa); etc. Also similar to FT others from Mycobacterium tuberculosis e.g. FT ECHA16|Rv2831|MTCY16B7.11c (249 aa), FASTA scores: opt: FT 232, E(): 1.3e-15, (33.8% identity in 204 aa overlap); etc. FT TBparse score is 0.916." FT /db_xref="GOA:Q7U004" FT /db_xref="HSSP:1DCI" FT /db_xref="InterPro:IPR018376" FT /db_xref="UniProtKB/Swiss-Prot:Q7U004" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96174.1" FT /translation="MPHRCAAQVVAGYRSTVSLVLVEHPRPEIAQITLNRPERMNSMAF FT DVMVPLKEALAQVSYDNSVRVVVLTGAGRGFSSGADHKSAGVVPHVENLTRPTYALRSM FT ELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGLTAS FT ELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAERIGLVSRQVPDEQLLDACYAIAARMA FT GFSRPGIELTKRTLWSGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPVF FT TDDT" FT CDS 43402..45030 FT /transl_table=11 FT /gene="Mb1508" FT /locus_tag="Mb1508" FT /product="PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER" FT /note="Mb1508, -, len: 542 aa. Equivalent to Rv1473, len: FT 542 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 542 aa overlap). Possible macrolide-transport FT ATP-binding protein ABC transporter (see citation below), FT possibly in EF-3 subfamily. Similar to many FT ABC-transporters e.g. D90909_48|YHES_HAEIN from FT Synechocystis sp. strain PCC6803 (574 aa), FASTA scores: FT opt: 870, E(): 0, (33.3% identity in 525 aa overlap); FT P44808|YHES_HAEIN from Haemophilus influenzae (638 aa), FT FASTA scores: opt: 706, E(): 0, (33.7% identity in 517 aa FT overlap); etc. Contains two PS00017 ATP/GTP-binding site FT motif A (P-loop), and two PS00211 ABC transporter family FT signatures. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FT FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7U003" FT /db_xref="HSSP:1US8" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U003" FT /protein_id="CAD96175.1" FT /translation="MITATDLEVRAGARILLAPDGPDLRVQPGDRIGLVGRNGAGKTTT FT LRILAGEVEPYAGSVTRAGEIGYLPQDPKVGDLDVLARDRVLSARGLDVLLTDLEKQQA FT LMAEVADEDERDRAIRRYGQLEERFVALGGYGAESEAGRICASLGLPERVLTQRLRTLS FT GGQRRRVELARILFAASESGAGNSTTLLLDEPTNHLDADSLGWLRDFLRLHTGGLVVIS FT HNVDLVADVVNKVWFLDAVRGQVDVYNMGWQRYVDARATDEQRRIRERANAERKAAALR FT AQAAKLGAKATKAVAAQNMLRRADRMMAALDEERVADKVARIKFPTPAACGRTPLVANG FT LGKTYGSLEVFTGVDLAIDRGSRVVILGLNGAGKTTLLRLLAGVEQPDTGVLEPGYGLR FT IGYFAQEHDTLDNDATVWENVRHAAPDAGEQDLRGLLGAFMFTGPQLEQPAGTLSGGEK FT TRLALAGLVASTANVLLLDEPTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAAALGP FT QRVVLLPDGTEDYWSDEYRDLIELA" FT CDS 45127..45318 FT /transl_table=11 FT /gene="Mb1509" FT /locus_tag="Mb1509" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1509, -, len: 63 aa. Equivalent to Rv1473A, len: FT 63 aa, from Mycobacterium tuberculosis strain H37Rv, (98.4% FT identity in 63 aa overlap). Possible transcriptional FT regulator, CDS predicted by GC plot. Similar to FT SCI8.24c|AL132644_24 putative transcriptional regulator FT from Streptomyces coelicolor (73 aa), FASTA scores: opt: FT 210, E(): 1.5e-08, (56.15% identity in 57 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U002" FT /protein_id="CAD96176.1" FT /translation="MRKSKKTRDQLLRELRNAYEGGASIRNLAATTGRSYGSIHSMLRE FT SGTTMRGRGGPNRRPRPR" FT CDS complement(45387..45950) FT /transl_table=11 FT /gene="Mb1510c" FT /locus_tag="Mb1510c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1510c, -, len: 187 aa. Equivalent to Rv1474c, len: FT 187 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 187 aa overlap). Probable transcription FT regulator, equivalent to AF0021|AF002133_1 transcriptional FT regulator from Mycobacterium avium strain GIR10 (82 aa), FT FASTA scores: opt: 490, E(): 6.7e-26, (92.5% identity in 80 FT aa overlap). Also similar to Q59431|UIDR_ECOLI UID OPERON FT REPRESSOR (GUS OPERON) from Escherichia coli (196 aa), FT FASTA scores: opt: 192, E(): 5.8e-06, (28.5% identity in FT 172 aa overlap). BELONGS TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS. Helix turn helix motif FT predicted at aa 33-54 (+3.40 SD)." FT /db_xref="GOA:Q7U001" FT /db_xref="HSSP:1BJY" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U001" FT /protein_id="CAD96177.1" FT /translation="MPKVSEDHLAARRRQILDGARRCFAEYGYDKATVRRLEQAIGMSR FT GAIFHHFRDKDALFFALAREDTERMAAVASREGLIGVMRDMLAAPDQFDWLATRLEIAR FT KLRNDPDFSRGWAERSAELAAATTDRLRRQKQANRVRDDVPSDVLRCYLDLVLDGLLAR FT LASGEDPQRLAAVLDLVENSVRRS" FT CDS complement(45961..48792) FT /transl_table=11 FT /gene="acn" FT /locus_tag="Mb1511c" FT /product="PROBABLE ACONITATE HYDRATASE ACN (Citrate FT hydro-lyase) (Aconitase)" FT /EC_number="4.2.1.3" FT /note="Mb1511c, acn, len: 943 aa. Equivalent to Rv1475c, FT len: 943 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 943 aa overlap). Probable acn, aconitate FT hydratase (EC 4.2.1.3), similar to many e.g. FT P70920|ACON_BRAJA ACONITATE HYDRATASE from Bradyrhizobium FT japonicum (906 aa), FASTA scores: opt:1912, E(): 0, (54.8% FT identity in 958 aa overlap); closest to AF0021|AF002133_2 FT Mycobacterium avium strain GIR10 (961 aa), FASTA scores: FT opt: 5072, E(): 0, (82.8% identity in 943 aa overlap). NOTE FT ACONITASE HAS AN ACTIVE (4FE-4S) AND AN INACTIVE (3FE-4S) FT FORMS. THE ACTIVE (4FE-4S) CLUSTER IS PART OF THE CATALYTIC FT SITE THAT INTERCONVERTS CITRATE, CIS-ACONITASE, AND FT ISOCITRATE." FT /db_xref="GOA:Q7U000" FT /db_xref="HSSP:1AMJ" FT /db_xref="InterPro:IPR018136" FT /db_xref="UniProtKB/TrEMBL:Q7U000" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96178.1" FT /translation="MTSKSVNSFGAHDTLKVGEKSYQIYRLDAVPNTAKLPYSLKVLAE FT NLLRNEDGSNITKDHIEAIANWDPKAEPSIEIQYTPARVVMQDFTGVPCIVDLATMREA FT IADLGGNPDKVNPLAPADLVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQG FT AFDDFKVVPPGTGIVHQVNIEYLASVVMTRDGVAYPDTCVGTDSHTTMVNGLGVLGWGV FT GGIEAEAAMLGQPVSMLIPRVVGFRLTGEIQPGVTATDVVLTVTEMLRQHGVVGKFVEF FT YGEGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETIKYLRFTGRTPEQVALVEAYAKA FT QGMWHDPKHEPEFSEYLELNLSDVVPSIAGPKRPQDRIALAQAKSTFREQIYHYVGNGS FT PDSPHDPHSKLDEVVEETFPASDPGQLTFANDDVATDETVHSAAAHADGRVSNPVRVKS FT DELGEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVEKGLTSKPWVKTTIAPGS FT QVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISKAVNDNDLSVTAVLSG FT NRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFDFQTQPLGQDKDGKNVFLRDIWPSQ FT QDVSDTIAAAINQEMFTRNYADVFKGDDRWRNLPTPSGNTFEWDPNSTYVRKPPYFEGM FT TAKPEPVGNISGARVLALLGDSVTTDHISPAGAIKPGTPAARYLDEHGVDRKDYNSFGS FT RRGNHEVMIRGTFANIRLRNQLLDDVSGGYTRDFTQPGGPQAFIYDAAQNYAAQHIPLV FT VFGGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGMGVIPLQFPEGKSASS FT LGLDGTEVFDITGIDVLNDGKTPKTVCVQATKGDGATIEFDAVVRIDTPGEADYYRNGG FT ILQYVLRNILKSG" FT CDS 48950..49510 FT /transl_table=11 FT /gene="Mb1512" FT /locus_tag="Mb1512" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb1512, -, len: 186 aa. Equivalent to Rv1476, len: FT 186 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 186 aa overlap). Possible membrane protein, FT TMhelix 138-60." FT /db_xref="UniProtKB/TrEMBL:Q7TZZ9" FT /protein_id="CAD96179.1" FT /translation="MTGPYFPQTIPFLPSYIPQDVDMTAVKAEVAALGVSAPPAATPGL FT LEVVQHARDEGIDLKIVLLDHNPPNDTPLRDIATVVGADYSDATVLVLSPNYVGSYSTQ FT YPRVTLEAGEDHSKTGNPVQSAQNFVHELSTPEFPWSALTIVLLIGVLAAAVGARLMQL FT RGRRSATSTDAAPGAGDDLNQGV" FT CDS 49736..51154 FT /transl_table=11 FT /gene="Mb1513" FT /locus_tag="Mb1513" FT /product="HYPOTHETICAL INVASION PROTEIN" FT /note="Mb1513, -, len: 472 aa. Equivalent to Rv1477, len: FT 472 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 472 aa overlap). Hypothetical Invasion protein. FT Possibly exported protein with unusually long signal FT sequence. The last 277 residues are nearly identical to FT those of AF0060|AF006054_1 hypothetical invasion protein FT INV1 from Mycobacterium tuberculosis (277 aa), FASTA FT scores: opt: 1833, E(): 0, (98.2% identity in 277 aa FT overlap); also very similar to AF0021|AF002133_4 invasin 1 FT protein from Mycobacterium avium (273 aa), FASTA scores: FT opt: 1452, E(): 0, (78.1% identity in 279 aa overlap). FT Similar to Rv1566c|MTCY336.37|Z95586 Mycobacterium FT tuberculosis cosmid (230 aa), FASTA scores: opt: 528, E(): FT 4.4e-20, (52.0% identity in 150 aa overlap); and weakly FT similar to p60 proteins of Listeria spp throughout its FT length e.g. M80351|LISIAPB_1 Listeria monocytogenes FT iap-related protein (478 aa), FASTA scores: opt: 251, E(): FT 8e-06, (24.4% identity in 487 aa overlap). C-terminal FT domain highly similar to next ORF Rv1478|MTV007.25." FT /db_xref="InterPro:IPR000064" FT /db_xref="UniProtKB/TrEMBL:Q7TZZ8" FT /protein_id="CAD96180.1" FT /translation="MRRNRRGSPARPAARFVRPAIPSALSVALLVCTPGLATADPQTDT FT IAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVSQRAVKD FT ANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAAKTLSASSQAVMANLQ FT RARTERVNTESAARLAKQKADKAAADAKASQDAAVAALTETRRKFDEQREEVQRLAAER FT DAAQARLQAARLVAWSSEGGQGAPPFRMWDPGSGPAGGRAWDGLWDPTLPMIPSANIPG FT DPIAVVNQVLGISATSAQVTANMGRKFLEQLGILQPTDTGITNAPAGSAQGRIPRVYGR FT QASEYVIRRGMSQIGVPYSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLP FT HYSGSQYNLGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVR FT TAGMTPYVVRYIEY" FT CDS 51165..51890 FT /transl_table=11 FT /gene="Mb1514" FT /locus_tag="Mb1514" FT /product="HYPOTHETICAL INVASION PROTEIN" FT /note="Mb1514, -, len: 241 aa. Equivalent to Rv1478, len: FT 241 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 241 aa overlap). Hypothetical Invasion protein. FT Possibly exported protein, nearly identical to FT AF0060|AF006054_2 hypothetical invasion protein INV2 of M. FT tuberculosis (240 aa), FASTA scores: opt: 1509, E(): 0, FT (95.0% identity in 241 aa overlap); very similar to FT AF0021|AF002133_5 hypothetical invasion protein INV2 from FT Mycobacterium avium (244 aa), FASTA scores: opt: 1269, FT E():0, (78.0% identity in 246 aa overlap). Also similar to FT Mycobacterium tuberculosis protein MTCY336.37 and weakly FT similar to C-terminal segment of p60 proteins of Listeria FT spp.e.g. Q01836|P60_LISIN PROTEIN P60 PRECURSOR (481 aa), FT FASTA scores: opt: 241, E():4e-07, (37.7% identity in 122 FT aa overlap). Highly similar to C-terminal domain of FT preceeding ORF Rv1477|MTV007.24 (472 aa), FASTA scores: FT opt: 864, E(): 0, (60.1% identity in 213 aa overlap)." FT /db_xref="InterPro:IPR000064" FT /db_xref="UniProtKB/TrEMBL:Q7TZZ7" FT /protein_id="CAD96181.1" FT /translation="MRHTRFHPIKLAWITAVVAGLMVGVATPADAEPGQWDPTLPALVS FT AGAPGDPLAVANASLQATAQATQTTLDLGRQFLGGLGINLGGPAASAPSAATTGASRIP FT RANARQAVEYVIRRAGSQMGVPYSWGGGSLQGPSKGVDSGANTVGFDCSGLVRYAFAGV FT GVLIPRFSGDQYNAGRHVPPAEAKRGDLIFYGPGGGQHVTLYLGNGQMLEASGSAGKVT FT VSPVRKAGMTPFVTRIIEY" FT CDS 52029..53162 FT /transl_table=11 FT /gene="moxR1" FT /locus_tag="Mb1515" FT /standard_name="moxR" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT MOXR1" FT /note="Mb1515, moxR1, len: 377 aa. Equivalent to Rv1479, FT len: 377 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 377 aa overlap). Probable moxR1, FT transcriptional regulatory protein, similar to FT X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi FT (329 aa), FASTA scores: opt: 850, E():0, (43.5% identity in FT 317 aa overlap); and P. denitrificans. Highly similar to FT MoxR homologs of Mycobacterium tuberculosis and M. avium FT (but these both differ at C-terminus) e.g. Rv3692, Rv3164c, FT and AF0021|AF002133_6 Mycobacterium avium strain GIR10 (309 FT aa), FASTA scores: opt: 1181, E(): 0, (83.7% identity in FT 227 aa overlap). Also similar to O33173|AF006054 MoxR FT fragment from Mycobacterium tuberculosis (211 aa), FASTA FT scores: opt: 1305, E(): 0, (94.3% identity in 212 aa FT overlap). Note that previously known as moxR." FT /db_xref="GOA:Q7TZZ6" FT /db_xref="InterPro:IPR016366" FT /db_xref="UniProtKB/TrEMBL:Q7TZZ6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96182.1" FT /translation="MTSAGGFPAGAGGYQTPGGHSASPAHEAPPGGAEGLAAEVHTLER FT AIFEVKRIIVGQDQLVERMLVGLLSKGHVLLEGVPGVAKTLAVETFARVVGGTFSRIQF FT TPDLVPTDIIGTRIYRQGREEFDTELGPVVANFLLADEINRAPAKVQSALLEVMQERHV FT SIGGRTFPMPSPFLVMATQNPIEHEGVYPLPEAQRDRFLFKINVGYPSPEEEREIIYRM FT GVTPPQAKQILSTGDLLRLQEIAANNFVHHALVDYVVRVVFATRKPEQLGMNDVKSWVA FT FGASPRASLGIIAAARSLALVRGRDYVIPQDVIEVIPDVLRHRLVLTYDALADEISPEI FT VINRVLQTVALPQVNAVPQQGHSVPPVMQAAAAASGR" FT CDS 53159..54112 FT /transl_table=11 FT /gene="Mb1516" FT /locus_tag="Mb1516" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1516, -, len: 317 aa. Equivalent to Rv1480, len: FT 317 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 317 aa overlap). Conserved hypothetical FT protein, last 110 aa residues correspond to first 110 aa of FT YS01_MYCAV|O07394 hypothetical 18.7 KD Mycobacterium avium FT protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, FT (84.2% identity in 114 aa overlap). Also similar to FT Mycobacterium tuberculosis hypothetical proteins Rv3163c FT and Rv3693." FT /db_xref="InterPro:IPR002035" FT /db_xref="UniProtKB/Swiss-Prot:P64854" FT /protein_id="CAD96183.1" FT /translation="MTESKAPAVVHPPSMLRGDIDDPKLAAALRTLELTVKQKLDGVLH FT GDHLGLIPGPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDM FT SASLDFGTACCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHT FT MLRTIATMPQAPAGVRGDLAVAIDALRRPERRRGMAVIISDFLGPINWMRPLRAIAARH FT EVLAIEVLDPRDVELPDVGDVVLQDAESGVVREFSIDPALRDDFARAAAAHRADVARTI FT RGCGAPLLSLRTDRDWLADIVRFVASRRRGALAGHQ" FT CDS 54123..55130 FT /transl_table=11 FT /gene="Mb1517" FT /locus_tag="Mb1517" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb1517, -, len: 335 aa. Equivalent to Rv1481, len: FT 335 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 335 aa overlap). Probable membrane protein, FT highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kd FT protein mav335 from M. avium (335 aa), FASTA scores: opt: FT 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar FT to AF116251|AF116251_1 BatA protein from Bacteroides FT fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, FT (26.5% identity in 340 aa overlap)." FT /db_xref="GOA:P64856" FT /db_xref="InterPro:IPR002035" FT /db_xref="UniProtKB/Swiss-Prot:P64856" FT /protein_id="CAD96184.1" FT /translation="MTLPLLGPMTLSGFAHSWFFLFLFVVAGLVALYILMQLARQRRML FT RFANMELLESVAPKRPSRWRHVPAILLVLSLLLFTIAMAGPTHDVRIPRNRAVVMLVID FT VSQSMRATDVEPSRMVAAQEAAKQFADELTPGINLGLIAYAGTATVLVSPTTNREATKN FT ALDKLQFADRTATGEAIFTALQAIATVGAVIGGGDTPPPARIVLFSDGKETMPTNPDNP FT KGAYTAARTAKDQGVPISTISFGTPYGFVEINDQRQPVPVDDETMKKVAQLSGGNSYNA FT ATLAELRAVYSSLQQQIGYETIKGDASVGWLRLGALALALAALAALLINRRLPT" FT CDS complement(55203..56045) FT /transl_table=11 FT /gene="Mb1518c" FT /locus_tag="Mb1518c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1518c, -, len: 280 aa. Equivalent to Rv1482c, len: FT 280 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 280 aa overlap). Conserved hypothetical FT protein, highly similar to O07396|AF002133 Mycobacterium FT avium protein MAV346 (346 aa), FASTA scores: E(): 0, (65.2% FT identity in 342 aa overlap); slight similarity to FT GRPE_ECOLI|P09372 heat shock protein from E. coli (197 aa), FT FASTA scores: opt: 139, E(): 0.012, (28.3% identity in 159 FT aa overlap). Similar to Mycobacterium tuberculosis FT hypothetical proteins Rv3517, Rv3555c, Rv3714c, Rv1073, FT etc. Start changed since first submission (-59 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7TZZ5" FT /protein_id="CAD96185.1" FT /translation="MTDPFLGSEALAAGVLTPYELRSRYVALHKDVYVPQGVELTAQLR FT AKALWLRSRRRGVLAGYSASAFHGAKWIDADLPAAIIDTNRRRAPGLQVWEERIEPDEI FT CVIEGMRVTTPERTALDLTSRFPLDPAVAAVDALIQATDLKVADVEPLIERYRGRRGMK FT AARAALDLVDGGAQSPKETWLRLLLIRAGFPRPQTQIAVRNEWGWAEAHLDMGWQDIKV FT AAEYDGDHHLTSRYHYRKDILRHEKVQHRYGWIVVRVVAEDHPADIIRRVGEARAFRA" FT CDS 56186..56929 FT /transl_table=11 FT /gene="fabG1" FT /locus_tag="Mb1519" FT /standard_name="mabA" FT /product="PROBABLE 3-OXOACYL-[ACYL-CARRIER PROTEIN] FT REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN FT REDUCTASE)" FT /EC_number="1.1.1.100" FT /note="Mb1519, fabG1, len: 247 aa. Equivalent to Rv1483, FT len: 247 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 247 aa overlap). Probable fabG1 FT (alternate gene name: mabA), 3-oxoacyl-[acyl-carrier FT protein] reductase (EC 1.1.1.100), equivalent to FT O07399|FABG_MYCAV 3-OXOACYL-[ACYL-CARRIER PROTEIN] FT REDUCTASE from Mycobacterium avium (255 aa); FT P71534|FABG_MYCSM 3-OXOACYL-[ACYL-CARRIER PROTEIN] FT REDUCTASE from Mycobacterium smegmatis (255 aa); and FT NP_302228.1|NC_002677 3-oxoacyl-[ACP] reductase (aka MabA) FT from Mycobacterium leprae (253 aa). Also highly similar to FT many e.g. T36779 probable 3-oxacyl-(acyl-carrier-protein) FT reductase from Streptomyces coelicolor (234 aa); FT FABG_ECOLI|P25716|NP_415611.1|NC_000913 FT 3-oxoacyl-[acyl-carrier-protein] reductase from Escherichia FT coli strain K12 (244 aa), FASTA scores: opt: 664, E(): FT 6.8e-35, (44.4% identity in 241 aa overlap); etc. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P0A5Y5" FT /db_xref="HSSP:1FK8" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Y5" FT /protein_id="CAD96186.1" FT /translation="MTATATEGAKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAVT FT HRGSGAPKGLFGVECDVTDSDAVDRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEK FT FEKVINANLTGAFRVAQRASRSMQRNKFGRMIFIGSVSGSWGIGNQANYAASKAGVIGM FT ARSIARELSKANVTANVVAPGYIDTDMTRALDERIQQGALQFIPAKRVGTPAEVAGVVS FT FLASEDASYISGAVIPVDGGMGMGH" FT CDS 56948..57757 FT /transl_table=11 FT /gene="inhA" FT /locus_tag="Mb1520" FT /product="NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] FT REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)" FT /EC_number="1.3.1.9" FT /note="Mb1520, inhA, len: 269 aa. Equivalent to Rv1484, FT len: 269 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 269 aa overlap). inhA, NADH-dependent FT enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.9) (see FT citations below). Identical to INHA_MYCTU|P46533 FT enoyl-[acyl-carrier-protein] reductase from Mycobacterium FT tuberculosis and G1155270 Mycobacterium bovis enoyl acp FT reductase. SOME SIMILARITY TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P0A5Y7" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Y7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96187.1" FT /translation="MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLR FT LIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMG FT INPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTV FT AKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGW FT DQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL" FT CDS 57763..58797 FT /transl_table=11 FT /gene="hemZ" FT /locus_tag="Mb1521" FT /product="FERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME FT SYNTHETASE)" FT /EC_number="4.99.1.1" FT /note="Mb1521, hemZ, len: 344 aa. Equivalent to Rv1485, FT len: 344 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 344 aa overlap). hemZ, ferrochelatase (EC FT 4.99.1.1) (see citation below), similar to many e.g. FT HEMZ_BACSU|P32396 ferrochelatase from Bacillus subtilus FT (310 aa), FASTA scores: opt:490, E(): 2e-24, (30.2% FT identity in 295 aa overlap); etc. BELONGS TO THE FT FERROCHELATASE FAMILY." FT /db_xref="GOA:P0A577" FT /db_xref="HSSP:1DOZ" FT /db_xref="InterPro:IPR019772" FT /db_xref="UniProtKB/Swiss-Prot:P0A577" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96188.1" FT /translation="MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHY FT LHFGGVSPINGINRTLIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAAVFAT FT SAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAATVRG FT DARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPW FT LEPDVTDQLTGLAGAGINAVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTP FT NADPRFARLARGLIDELRYGRIPARVSGPDPVPGCLSSINGQPCRPPHCVASVSPARPS FT AGSP" FT CDS complement(58763..59629) FT /transl_table=11 FT /gene="Mb1522c" FT /locus_tag="Mb1522c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1522c, -, len: 288 aa. Equivalent to Rv1486c, len: FT 288 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 288 aa overlap). Conserved hypothetical FT protein, highly similar to YS07_MYCAV|O07402 hypothetical FT 33.5 kd protein mav321 from Mycobacterium avium (320 aa), FT FASTA scores: opt: 1217, E(): 0, (71.1% identity in 315 aa FT overlap). Weak similarity to AL079332|SCI5.07 hypothetical FT protein from Streptomyces coelicolor (259 aa), FASTA FT scores: opt: 131, E(): 0.29, (32.3% identity in 279 aa FT overlap). Start changed since original submission." FT /db_xref="UniProtKB/Swiss-Prot:P59980" FT /protein_id="CAD96189.1" FT /translation="MWCPSVSLSIWANAWLAGKAAPDDVLDALSLWAPTQSVAAYDAVA FT AGHTGLPWPDVHDAGTVSLLQTLRAAVGRRRLRGTINVVLPVPGDVRGLAAGTQFEHDA FT LAAGEAVIVANPEDPGSAVGLVPEFSYGDVDEAAQSEPLTPELCALSWMVYSLPGAPVL FT EHYELGDAEYALRSAVRSAAEALSTIGLGSSDVANPRGLVEQLLESSRQHRVPDHAPSR FT ALRVLENAAHVDAIIAVSAGLSRLPIGTQSLSDAQRATDALRPLTAVVRSARMSAVTAI FT LHSAWPD" FT CDS 59687..60121 FT /transl_table=11 FT /gene="Mb1523" FT /locus_tag="Mb1523" FT /product="CONSERVED MEMBRANE PROTEIN" FT /note="Mb1523, -, len: 144 aa. Equivalent to Rv1487, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 144 aa overlap). Conserved membrane protein. FT Highly similar to O07404|AF002133 MAV145 from Mycobacterium FT avium (145 aa), FASTA scores: opt: 667, E(): 0, (72.5% FT identity in 142 aa overlap). Also similar to FT AL079332|SCI5.05 hypothetical protein from Streptomyces FT coelicolor (143 aa), FASTA scores: opt: 344, E(): 1.3e-15, FT (44.8% identity in 134 aa overlap)." FT /db_xref="InterPro:IPR002810" FT /db_xref="UniProtKB/TrEMBL:Q7TZZ4" FT /protein_id="CAD96190.1" FT /translation="MPVALIWLIAALVLVGAEALTGDMFLLMLGGGALAASVSSWLLAW FT PMWADGAVFLLVSVLLLVLVRPAVRRRLTQTKGVQLGIEALEGKKAVVLGRVARDGGQV FT KLDGQVWTARPLNDGDVFEPGDSVTVVQIDGATAVVFKDV" FT CDS 60143..61288 FT /transl_table=11 FT /gene="Mb1524" FT /locus_tag="Mb1524" FT /product="POSSIBLE EXPORTED CONSERVED PROTEIN" FT /note="Mb1524, -, len: 381 aa. Equivalent to Rv1488, len: FT 381 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 381 aa overlap). Possible exported conserved FT protein; contains possible N-terminal signal sequence. FT Similar to YBBK_ECOLI|P77367 hypothetical protein ybbK from FT Escherichia coli (305 aa), FASTA scores: opt: 716, E(): 0, FT (37.1% identity in 307 aa overlap). Similar to FT stomatin-like proteins e.g. AF065260|AF065260_1 Clostridium FT difficile (320 aa), FASTA scores: opt: 767, E(): 0, (42.3% FT identity in 307 aa overlap)." FT /db_xref="GOA:P63694" FT /db_xref="InterPro:IPR001972" FT /db_xref="UniProtKB/Swiss-Prot:P63694" FT /protein_id="CAD96191.1" FT /translation="MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSR FT TVSGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAV FT YEISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRVARV FT ELRSIDPPPSIQASMEKQMKADREKRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQ FT AAILAAEADRQSRMLRAQGERAAAYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQT FT LPEMARGDANKVWVVPSDFNAALQGFTRLLGKPGEDGVFRFEPSPVEDQPKHAADGDDA FT EVAGWFSTDTDPSIARAVATAEAIARKPVEGSLGTPPRLTQ" FT CDS 61298..61654 FT /transl_table=11 FT /gene="Mb1525" FT /locus_tag="Mb1525" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1525, -, len: 118 aa. Equivalent to Rv1489, len: FT 118 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 118 aa overlap). Conserved hypothetical FT protein, similar to hypothetical proteins from FT Mycobacterium avium subsp. paratuberculosis and FT Streptomyces coelicolor e.g. AJ250017_1 insertion sequence FT IS900, Locus 3, putative invasion protein from M. FT paratuberculosis (138 aa), FASTA scores: opt: 120, E(): FT 0.26, (34.375% identity in 96 aa overlap); FT SCD6.11c|AL353815_11 possible integral membrane protein FT from Streptomyces coelicolor (136 aa), FASTA scores: opt: FT 106, E(): 2.2, (35.9% identity in 103 aa overlap). ORF FT predicted by GC plot. Replaces previous Rv1489c on other FT strand." FT /db_xref="UniProtKB/TrEMBL:Q7TZZ3" FT /protein_id="CAD96192.1" FT /translation="MSGLTSPKTYAVLAALQAGDAVACAIPLPPIARLLDDLDVPVSVR FT PVLPVVKAASAVGLLSVTRFPALARLTTAMLTLYFILAVGAHVRVRDRVVNAIPAASFL FT TLFALMTAKGPERT" FT CDS 61688..61918 FT /transl_table=11 FT /gene="Mb1526" FT /locus_tag="Mb1526" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1526, -, len: 76 aa. Equivalent to Rv489A, len: 76 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 76 aa overlap). Conserved hypothetical protein, FT similar to part of alpha subunit of many methylmalonyl-CoA FT mutases (~750 aa). Size difference suggests possible gene FT fragment although Mycobacterium tuberculosis has intact FT methylmalonyl-CoA mutase gene. P71774|MUTB_MYCTU PROBABLE FT METHYLMALONYL-COA MUTASE from Mycobacterium tuberculosis FT (750 aa), FASTA scores: opt: 258, E(): 3.2e-10, (73.35% FT identity in 60 aa overlap). ORF predicted by GC plot." FT /db_xref="GOA:Q7TZZ2" FT /db_xref="HSSP:7REQ" FT /db_xref="InterPro:IPR006099" FT /db_xref="UniProtKB/TrEMBL:Q7TZZ2" FT /protein_id="CAD96193.1" FT /translation="MSVGEVEVLKVENSRVRAEQLAKLYELRSSRDRVRVDAALAELSR FT AAAARGCAGTSGLGNNLMAPGPPHSLLGRDR" FT CDS 62068..63375 FT /transl_table=11 FT /gene="Mb1527" FT /locus_tag="Mb1527" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb1527, -, len: 435 aa. Equivalent to Rv1490, len: FT 435 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 435 aa overlap). Probable membrane protein." FT /db_xref="GOA:P64858" FT /db_xref="UniProtKB/Swiss-Prot:P64858" FT /protein_id="CAD96194.1" FT /translation="MSQCFAVKGIGGADQATLGSAEILVKYAQLADKRARVYVLVSTWL FT VVWGIWHVYFVEAVFPNAILWLHYYAASYEFGFVRRGLGGELIRMLTGDHFFAGAYTVL FT WTSITVWLIALAVVVWLILSTGNRSERRIMLALLVPVLPFAFSYAIYNPHPELFGMTAL FT VAFSIFLTRAHTSRTRVILSTLYGLTMAVLALIHEAIPLEFALGAVLAIIVLSKNATGA FT TRRICTALAIGPGTVSVLLLAVVGRRDIADQLCAHIPHGMVENPWAVATTPQRVLDYIF FT GRVESHADYHDWVCEHVTPWFNLDWITSAKLVAVVGFRALFGAFLLGLLFFVATTSMIR FT YVSAVPVRTFFAELRGNLALPVLASALLVPLFITAVDWTRWWVMITLDVAIVYILYAID FT RPEIEQPPSRRNVQVFVCVVLVLAVIPTGSANNIGR" FT CDS complement(63954..64712) FT /transl_table=11 FT /gene="Mb1528c" FT /locus_tag="Mb1528c" FT /product="CONSERVED MEMBRANE PROTEIN" FT /note="Mb1528c, -, len: 252 aa. Equivalent to Rv1491c, len: FT 252 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 252 aa overlap). Conserved membrane protein. FT Similar to hypothetical proteins from many organisms e.g. FT YDJZ_ECOLI|P76221 Escherichia coli (235 aa), FASTA scores: FT opt: 223, E():6.7e-07, (31.7% identity in 145 aa overlap); FT AL133252|SCE46.15 Streptomyces coelicolor (249 aa), FASTA FT scores: opt: 378, E(): 1.5e-17, (39.1% identity in 169 aa FT overlap). Also similar to M. tuberculosis hypothetical FT protein Rv0625c." FT /db_xref="GOA:P67118" FT /db_xref="InterPro:IPR015414" FT /db_xref="UniProtKB/Swiss-Prot:P67118" FT /protein_id="CAD96195.1" FT /translation="MTAPAICNTTETVHGIATSLGAVARQASLPRIVGTVVGITVLVVV FT ALLVPVPTAVELRDWAKSLGAWFPLAFLLVHTVVTVPPFPRTAFTLAAGLLFGSVVGVF FT IAVVGSTASAVIAMLLVRATGWQLNSLVRRRAINRLDERLRERGWLAILSLRLIPVVPF FT AAINYAAGASGVRILSFAWATLAGLLPGTAAVVILGDAFAGSGSPLLILVSVCTGALGL FT TGLVYEIRNYRRQHRRMPGYDDPVREPALI" FT CDS 64903..66750 FT /transl_table=11 FT /gene="mutA" FT /locus_tag="Mb1529" FT /product="PROBABLE METHYLMALONYL-COA MUTASE SMALL SUBUNIT FT MUTA (MCM)" FT /EC_number="5.4.99.2" FT /note="Mb1529, mutA, len: 615 aa. Equivalent to Rv1492, FT len: 615 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 615 aa overlap). Probable mutA, FT Methylmalonyl-coa mutase small-subunit (EC 5.4.99.2), FT strong similarity to e.g. MUTA_STRCM|Q05064 FT methylmalonyl-coa mutase beta-subunit from Streptomyces FT cinnamonensis (616 aa), FASTA scores: opt: 1512, E(): 0, FT (45.9% identity in 628 aa overlap). Contains PS00213 FT Lipocalin signature, PS00544 Methylmalonyl-CoA mutase FT signature. BELONGS TO THE METHYLMALONYL-COA MUTASE FAMILY." FT /db_xref="GOA:P65486" FT /db_xref="HSSP:2REQ" FT /db_xref="InterPro:IPR004608" FT /db_xref="UniProtKB/Swiss-Prot:P65486" FT /protein_id="CAD96196.1" FT /translation="MSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLL FT DTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATAD FT TNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVM FT LALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDG FT PAFHNLGATAATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKM FT RALRQLWARVAEVVGDPGGGAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADT FT VLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRL FT ARRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPA FT LPPGDPTSPVRRYAAGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLL FT ASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRV FT YLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA" FT CDS 66751..69003 FT /transl_table=11 FT /gene="mutB" FT /locus_tag="Mb1530" FT /product="PROBABLE METHYLMALONYL-COA MUTASE LARGE SUBUNIT FT MUTB (MCM)" FT /EC_number="5.4.99.2" FT /note="Mb1530, mutB, len: 750 aa. Equivalent to Rv1493, FT len: 750 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 750 aa overlap). Probable mutB, FT Methylmalonyl-coa mutase large-subunit (EC 5.4.99.2), FT strong similarity to e.g. MUTB_STRCM|Q05065 FT methylmalonyl-coa mutase alpha-subunit from Streptomyces FT cinnamonensis (733 aa), FASTA scores: opt: 3562, E(): 0, FT (75.8% identity in 730 aa overlap). Contains PS00544 FT Methylmalonyl-CoA mutase signature. BELONGS TO THE FT METHYLMALONYL-COA MUTASE FAMILY." FT /db_xref="GOA:P65488" FT /db_xref="HSSP:1REQ" FT /db_xref="InterPro:IPR006098" FT /db_xref="UniProtKB/Swiss-Prot:P65488" FT /protein_id="CAD96197.1" FT /translation="MTTKTPVIGSFAGVPLHSERAAQSPTEAAVHTHVAAAAAAHGYTP FT EQLVWHTPEGIDVTPVYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTIRQ FT YAGFSTAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSIL FT DMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMV FT RNTYIYPPKPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVD FT YIRAGLNAGLDIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAQFAPKSAKSLS FT LRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIA FT RNTQLVLQQESGTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHGGMAQAISDGIP FT KLRIEEAAARTQARIDSGQQPVVGVNKYQVPEDHEIEVLKVENSRVRAEQLAKLQRLRA FT GRDEPAVRAALAELTRAAAEQGRAGADGLGNNLLALAIDAARAQATVGEISEALEKVYG FT RHRAEIRTISGVYRDEVGKAPNIAAATELVEKFAEADGRRPRILIAKMGQDGHDRGQKV FT IATAFADIGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALAQV FT GRPDIMIVVGGVIPPGDFDELYAAGATAIFPPGTVIADAAIDLLHRLAERLGYTLD" FT CDS 69017..69319 FT /transl_table=11 FT /gene="Mb1531" FT /locus_tag="Mb1531" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1531, -, len: 100 aa. Equivalent to Rv1494, len: FT 100 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 100 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P0A5F0" FT /protein_id="CAD96198.1" FT /translation="MPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAA FT IVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYESEAERSAARARRNARQQRSAQ" FT CDS 69316..69633 FT /transl_table=11 FT /gene="Mb1532" FT /locus_tag="Mb1532" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1532, -, len: 105 aa. Equivalent to Rv1495, len: FT 105 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 105 aa overlap). Conserved hypothetical FT protein, some similarity to Rv1942c|MTCY09F9.22 FT hypothetical protein from Mycobacterium tuberculosis (109 FT aa) (0.7% identity in 101 aa overlap) and Rv0659c, FT Rv1102c." FT /db_xref="GOA:P64860" FT /db_xref="InterPro:IPR011067" FT /db_xref="UniProtKB/Swiss-Prot:P64860" FT /protein_id="CAD96199.1" FT /translation="MNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTR FT RTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDYLGEVTPATMNKINTALATALGLPW FT P" FT CDS 69630..70634 FT /transl_table=11 FT /gene="Mb1533" FT /locus_tag="Mb1533" FT /product="Possible transport system kinase" FT /EC_number="2.7.-.-" FT /note="Mb1533, -, len: 334 aa. Equivalent to Rv1496, len: FT 334 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 334 aa overlap). Possible transport system FT kinase (EC 2.7.-.-). Equivalent to NP_302220.1|NC_002677 FT putative kinase from Mycobacterium leprae (327 aa). Highly FT similar to several transport system kinases and NTPase FT transporters e.g. P27254|ARGK_ECOLI|B2918 LAO/AO transport FT system kinase (EC 2.7.-.-) from Escherichia coli K12 (331 FT aa) (see citation below); NP_311815.1|NC_002695 ATPase FT component of two convergent arginine transporter from FT Escherichia coli O157:H7 (331 aa); etc. Also similar to FT YPLE_CAUCR|P37895 hypothetical 34.6 kd protein in FT Caulobacter crescentus (326 aa), FASTA scores, opt: 1125, FT E(): 0, (55.7% identity in 316 aa overlap)." FT /db_xref="GOA:P63578" FT /db_xref="InterPro:IPR005129" FT /db_xref="UniProtKB/Swiss-Prot:P63578" FT /protein_id="CAD96200.1" FT /translation="MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQAQ FT QLLLRLLPDSGNAHRVGITGVPGVGKSTAIEALGMHLIERGHRVAVLAVDPSSTRTGGS FT ILGDKTRMARLAVHPNAYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVGVGQ FT SEVAVANMVDTFVLLTLARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAARELS FT AAIRLIYPREALWRPPVLTMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRDQQVDW FT TWQLVRDAVLDRVWSNPTVRKVRSELERRVRAGELTPALAAQQILEIANLTDR" FT CDS 70687..71976 FT /transl_table=11 FT /gene="lipL" FT /locus_tag="Mb1534" FT /product="PROBABLE ESTERASE LIPL" FT /EC_number="3.1.-.-" FT /note="Mb1534, lipL, len: 429 aa. Equivalent to Rv1497, FT len: 429 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 429 aa overlap). Probable LipL, esterase FT (EC 3.1.-.-), very similar to Mycobacterium tuberculosis FT hypothetical esterases and penicillin binding proteins e.g. FT Rv1923, Rv2463, Rv3775, etc. Also similar to G151214|M68491 FT esterase estA from Pseudomonas sp (389 aa), FASTA scores: FT opt: 604, E(): 1e-31, (34.4% identity in 389 aa overlap)." FT /db_xref="GOA:Q7TZZ1" FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q7TZZ1" FT /protein_id="CAD96201.1" FT /translation="MMVDTGVDHRAVSSHDGPDAGRRVFGAADPRFACVVRAFASMFPG FT RRFGGGALAVYLDGQPVVDVWKGWADRAGWVPWSADSAPMVFSATKGMTATVIHRLADR FT GLIDYEAPVAEYWPAFGANGKATLTVRDVMRHQAGLSGLRGATQQDLLDHVVMEERLAA FT AVPGRLLGKSAYHALTFGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADA FT PTRVAEIIMPQDIAANAVLTCAMRRLAHRFSGGFRSMYFPGAIAAVQGEAPLLDAEIPA FT ANGVATARALARMYGAIANGGEIDGIRFLSRELVTGLTRNRRQVLPDRNLLVPLNFHLG FT YHGMPIGNVMPGFGHVGLGGSIGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLI FT RQAAAQARKRGYQPVTPFGAPYSEPGAAAG" FT CDS complement(72049..72666) FT /transl_table=11 FT /gene="Mb1535c" FT /locus_tag="Mb1535c" FT /product="PROBABLE METHYLTRANSFERASE" FT /EC_number="2.1.1.-" FT /note="Mb1535c, -, len: 205 aa. Equivalent to Rv498c, len: FT 205 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 205 aa overlap). Probable FT methyltransferase (EC 2.1.1.-). Similar to FT G2792343|AF040571 METHYLTRANSFERASE from AMYCOLATOPSIS FT MEDITERRANEI (272 aa), FASTA scores: E(): 5.1e-11, (32.3% FT identity in 124 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A." FT /db_xref="GOA:Q7TZZ0" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q7TZZ0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96202.1" FT /translation="MLDVGCGSGRMALPLTGYLNSEGRYAGFDISQKAIAWCQEHITSA FT HPNFQFEVSDIYNSLYNPKGKYQSLDFRFPYPDASFDVVFLTSVFTHMFPPDVEHYLDE FT ISRVLKPGGRCLCTYFLLNDESLAHIAEGKSAHNFQHEGPGYRTIHKKRPEEAIGLPET FT FVRDVYGKFGLAVHEPLHYGSWSGREPHLSFQDIVIATKTAS" FT CDS complement(72880..73071) FT /transl_table=11 FT /gene="Mb1536c" FT /locus_tag="Mb1536c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1536c, -, len: 63 aa. Equivalent to Rv1498A, len: FT 70 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 63 aa overlap). Conserved hypothetical protein, FT highly similar to other hypothetical proteins e.g. from FT Streptomyces coelicolor, Sinorhizobium meliloti and FT Pseudomonas aeruginosa. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a single base transition (a-g) at the FT 5' start leads to a shorter product compared to its homolog FT in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 FT aa)." FT /db_xref="InterPro:IPR009923" FT /db_xref="UniProtKB/TrEMBL:Q7TZY9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96203.1" FT /translation="MIEIVGTSPDGVDAAIQGGLARAAQTMRALDWFEVQSIRGHLVDG FT AVAHFQVTMKVGFRLEDS" FT CDS 73153..73551 FT /transl_table=11 FT /gene="Mb1537" FT /locus_tag="Mb1537" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1537, -, len: 132 aa. Equivalent to Rv1499, len: FT 132 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 132 aa overlap). Hypothetical unknown protein, FT was initially longer but has been shortened owing to FT overlap with Rv1498A." FT /db_xref="UniProtKB/TrEMBL:Q7TZY8" FT /protein_id="CAD96204.1" FT /translation="MPSGEPSTAGHFEHLPRGSFGRILSVLNAAADHHPRELLVVGIAT FT FDQKRPAVGVDEHDPGGAATPAVVINYESRSSAGGTIGHSTTSQVACCLYQQPKRPALR FT PTKAAATTAATTWIERVQNRRGRHSALV" FT CDS 73596..74624 FT /transl_table=11 FT /gene="Mb1538" FT /locus_tag="Mb1538" FT /product="PROBABLE GLYCOSYLTRANSFERASE" FT /EC_number="2.-.-.-" FT /note="Mb1538, -, len: 342 aa. Equivalent to Rv1500, len: FT 342 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 342 aa overlap). Probable glycosyltransferase FT (EC 2.-.-.- ), hydrophobic domain near C-terminus. Some FT similarity to putative glycosyl-transferases from Bacillus FT subtilis e.g. O34319|YKCC_BACSU (323 aa), opt: 490, E(): FT 6.1e-25, (28.85% identity in 312 aa overlap) and to FT N-acetyl glucosamine transferases. Also similar to G1001347 FT hypothetical 36.7 kDa protein (318 aa), FASTA scores: opt: FT 523, E(): 7.2e-26, (30.6% identity in 307 aa overlap)." FT /db_xref="GOA:Q7TZY7" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q7TZY7" FT /protein_id="CAD96205.1" FT /translation="MRLSIVTTMYMSEPYVLEFYRRARAAADKITPDVEIIFVDDGSPD FT AALQQAVSLLDSDPCVRVIQLSRNFGHHKAMMTGLAHATGDLVFLIDSDLEEDPALLEP FT FYEKLISTGADVVFGCHARRPGGWLRNFGPKIHYRASALLCDPPLHENTLTVRLMTADY FT VRSLVQHQERELSIAGLWQITGFYQVPMSVNKAWKGTTTYTFRRKVATLVDNVTSFSNK FT PLVFIFYLGAAIFIISSSAAGYLIIDRIFFRALQAGWASVIVSIWMLGGVTIFCIGLVG FT IYVSKVFIETKQRPYTIIRRIYGSDLTTREPSSLKTAFPAAHLSNGKRVTSEPEGLATG FT NR" FT CDS 74636..75457 FT /transl_table=11 FT /gene="Mb1539" FT /locus_tag="Mb1539" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1539, -, len: 273 aa. Equivalent to Rv1501, len: FT 273 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 273 aa overlap). Conserved hypothetical FT protein, some similarity to O06374|Rv3633|MTCY15C10.19C FT hypothetical protein from Mycobacterium tuberculosis, FASTA FT scores: E(): 3.9e-10, (27.5% identity in 280 aa overlap)." FT /db_xref="InterPro:IPR008775" FT /db_xref="UniProtKB/Swiss-Prot:P67771" FT /protein_id="CAD96206.1" FT /translation="MIPVKVENNTSLDQVQDALNCVGYAVVEDVLDEASLAATRDRMYR FT VQERILTEIGKERLARAGELGVLRLMMKYDPHFFTFLEIPEVLSIVDRVLSETAILHLQ FT NGFILPSFPPFSTPDVFQNAFHQDFPRVLSGYIASVNIMFAIDPFTRDTGATLVVPGSH FT QRIEKPDHTYLARNAVPVQCAAGSLFVFDSTLWHAAGRNTSGKDRLAINHQFTRSFFKQ FT QIDYVRALGDAVVLEQPARTQQLLGWYSRVVTNLDEYYQPPDKRLYRKGQG" FT CDS 75670..76020 FT /transl_table=11 FT /gene="Mb1540" FT /locus_tag="Mb1540" FT /product="HYPOTHETICAL PROTEIN [FIRST PART]" FT /note="Mb1540, -, len: 116 aa. Equivalent to the 5' end of FT Rv1502, len: 299 aa, from Mycobacterium tuberculosis strain FT H37Rv, (94.7% identity in 114 aa overlap). Hypothetical FT unknown protein. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base deletion (t-*), splits Rv1502 into 2 parts, FT Mb1540 and Mb1541. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base deletion (t-*), splits Rv1502 into 2 parts, FT Mb1540 and Mb1541." FT /db_xref="UniProtKB/TrEMBL:Q7TZY6" FT /protein_id="CAD96207.1" FT /translation="MAWRKLGRIFAPSGELDWSRSHAALPVPEWIEGDIFRIYFSGRDG FT QNRSSIGSVIVDLAVGGKILDIPAEPILRPGARGMFDDCGVSIGSIVRAGDTRLLYYTG FT WNSLSPCPGKTP" FT CDS 75999..76568 FT /transl_table=11 FT /gene="Mb1541" FT /locus_tag="Mb1541" FT /product="HYPOTHETICAL PROTEIN [SECOND PART]" FT /note="Mb1541, -, len: 189 aa. Equivalent to the 3' end of FT Rv1502, len: 299 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.5% identity in 189 aa overlap). Hypothetical FT unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZY5" FT /protein_id="CAD96208.1" FT /translation="MPWKNTIGVAISEAGAPFERWSTFPVVALDERDPFSLSYPWVIQD FT GGTYRMWYGSNLGWGEGTDEIPHVIRYAQSRDGVHWEKQDRVHIDTSGSDNSAACRPCV FT VRDAGVYRMWFCARGAKYRIYCATSEDGLTWRQLGKDEGIDVSPDSWDSDMIEYPCVFD FT HRGQRFMLYSGDGYGRTGFGLAVLEN" FT CDS complement(76741..77889) FT /transl_table=11 FT /gene="Mb1542c" FT /locus_tag="Mb1542c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1542c, -, len: 382 aa. Equivalent to Rv1503c and FT Rv1504c, len: 182 aa and 199 aa, from Mycobacterium FT tuberculosis strain H37Rv, (99.5% identity in 182 aa FT overlap and 100% identity in 199 aa overlap). Conserved FT hypothetical protein, similar to C-terminal region of FT P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN FT from Escherichia coli (376 aa), FASTA scores: opt: 565, FT E(): 0, (49.4% identity in 170 aa overlap) and similar to FT N-terminal region of P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE FT BIOSYNTHESIS PROTEIN from Escherichia coli (376 aa), FASTA FT scores: opt: 863, E(): 0, (68.0% identity in 194 aa FT overlap); Rv1503c and Rv1504c are both similar to FT RFFA_ECOLI but are separated by a stop codon, sequence FT appears to be correct so possible pseudogene. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1503c and Rv1504c exist as 2 FT genes. In Mycobacterium bovis, a single base transversion FT (t-g) leads to a single product." FT /db_xref="GOA:Q7TVB9" FT /db_xref="InterPro:IPR015422" FT /db_xref="UniProtKB/TrEMBL:Q7TVB9" FT /protein_id="CAD96209.1" FT /translation="MSDHKVPFNRPYMTGRELAYIAEAHSCGHLAGDGPFTRRSHAWLE FT QQTGCRKALLTPSCTAALEMMALLLDIEEGDEVILPSYTFVSTANAFVLRGGVPVFVDI FT RPDTLNIDETRIVDAITPRTKAIVPVHYAGVACEMDAIMKIATHHNLAVVEDAAQGAMA FT SYRGRALGSIGDLGALSFHETKNVISGEGGALLVNSEDFLLRAEILREKGTNRSRFLRN FT EVDKYTWQDKGSSYLPSELVAAFLWAQFEEAERITRIRLDLWNRYHESFESLEQRGLLR FT RPIIPQGCSHNAHMYYVLLAPSADREEVLARLTSKGIGAVFHYVPLHDSPAGRRYGRTN FT GNLTVTNDVASRLIRLPMWVGLQEVDQSRVVEALTRILTLRA" FT CDS complement(78026..78691) FT /transl_table=11 FT /gene="Mb1543c" FT /locus_tag="Mb1543c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1543c, -, len: 221 aa. Equivalent to Rv1505c, len: FT 221 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 221 aa overlap). Conserved hypothetical FT protein, some similarity to hypothetical proteins and FT glycosylases e.g. P71063|O08181 HYPOTHETICAL 22.5 KD FT PROTEIN YVFD from Bacillus subtilis (216 aa), FASTA scores: FT E(): 2.4e-08, (25.5% identity in 196 aa overlap)." FT /db_xref="GOA:Q7TZY4" FT /db_xref="InterPro:IPR020019" FT /db_xref="UniProtKB/TrEMBL:Q7TZY4" FT /protein_id="CAD96210.1" FT /translation="MTKPLVIFGSGDIAQLAHYYFTRDSEYEVVAFTVDRDYASVSEFC FT GLPLVAFDEVAQRFPPESHAMFVALAYAKLNGVRKEKYLAAKALGYELASYVSSHATVL FT NDGRIGENVFLLEDNTIQPFVSIGNNVTLWSGNHIGHHSTIHDHCFLASHIVVSGGVVI FT EEQSFIGVNATLRDHITIGSRCVVGAGALLLGDADADGVYIGTKTERRPVPSTELRKI" FT CDS 78884..79648 FT /transl_table=11 FT /gene="Mb1544" FT /locus_tag="Mb1544" FT /product="CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN" FT /note="Mb1544, -, len: 254 aa. Equivalent to Rv1517, len: FT 254 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 254 aa overlap). Conserved hypothetical FT transmembrane protein, similar to G466802|LEPB1170_F2_64 FT from Mycobacterium leprae (230 aa), FASTA scores: opt: 282, FT E(): 2.2e-11, (34.1% identity in 255 aa overlap). Also FT similar to Mycobacterium tuberculosis Rv3821|MTCY409.09c FT (237 aa) (36.3% identity in 256 aa overlap); and Rv3481c." FT /db_xref="GOA:Q7TZY3" FT /db_xref="UniProtKB/TrEMBL:Q7TZY3" FT /protein_id="CAD96211.1" FT /translation="MWTMVLLLGLGMAIDPARLGLAVVMLSRRRPMLNLFAFWVGGMVA FT GVGIALAVLVFMRDVALAAIQGVVSAANEFREAVGILAGGRLHIVIGVIMLLLAARMVA FT RARAQVGVPVGPVGVADGGMSALALAQRPPGLVARLEVRTQQMLQGDVVWPAFVVGVAS FT SAPPFESVVALTVIMASGAEIGTQFGAFVVFTLLVLAVIEIPLVAYLAIPQQTQQVMLR FT FQDWVRSNRRQISLTILIGVGFLFLYQGVTSL" FT CDS 79657..80616 FT /transl_table=11 FT /gene="Mb1545" FT /locus_tag="Mb1545" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1545, -, len: 319 aa. Equivalent to Rv1518, len: FT 319 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 319 aa overlap). Conserved hypothetical FT protein, possibly a glycosyl transferase involved in FT exopolysaccharide synthesis, similar to several FT hypothetical proteins and glycosyl transferases from FT diverse organisms e.g. P73996|D90911 from SYNECHO CYSTIS FT sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% FT identity in 241 aa overlap)." FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q7TZY2" FT /protein_id="CAD96212.1" FT /translation="MVPGDASSVVSVNPAKPLISVCIPMYNNGATIERCLRSILEQEGV FT EFEIVVVDDDSSDDCAAIAATMLRPGDRLLRNEPRLGLNRNHNKCLEVARGGLIQFVHG FT DDRLLPGALQTLSRRFEDPSVGMAFAPRRVESDDIKWQQRYGRVHTRFRKLRDRNHGPS FT LVLQMVLHGAKENWIGEPTAVMFRRQLALDAGGFRTDIYQLVDVDFWLRLMLRSAVCFV FT PHELSVRRHTAATETTRVMATRRNVLDRQRILTWLIVDPLSPNRVRSAAALWWIPAWLA FT MIVEVAVLGPQRRTHLKALAPAPFREFAHARRQLPLAD" FT CDS 80746..81015 FT /transl_table=11 FT /gene="Mb1546" FT /locus_tag="Mb1546" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1546, -, len: 89 aa. Equivalent to Rv1519, len: 89 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 89 aa overlap). Conserved hypothetical protein, FT high similarity to C-terminus of Q50723|MTCY78.26|Rv3402c FT (412 aa) (58.1% identity in 74 aa overlap)." FT /db_xref="InterPro:IPR000653" FT /db_xref="UniProtKB/Swiss-Prot:P64862" FT /protein_id="CAD96213.1" FT /translation="MRCGCLACDGVLCANGPGRPRRPALTCTAVATRTLHSLATNAELV FT ESADLTVTEDICSRIVSLPVHDHMAIADVARVVAPFGEGLARGG" FT CDS 81041..82081 FT /transl_table=11 FT /gene="Mb1547" FT /locus_tag="Mb1547" FT /product="probable sugar transferase" FT /EC_number="2.-.-.-" FT /note="Mb1547, -, len: 346 aa. Equivalent to Rv1520, len: FT 346 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 346 aa overlap). Probable sugar transferase (EC FT 2.-.-.-), similar to several e.g. AB010970|AB010970_6 FT Streptococcus mutans glycosyltransferase (465 aa), FASTA FT scores: opt: 381, E(): 1.2e-18, (31.7% identity in 240 aa FT overlap); O34234|Y07786 SUGAR TRANSFERASE from Vibrio FT cholerae (337 aa), FASTA scores: opt: 214, E(): 8.4e-05, FT (25.9% identity in 212 aa overlap). Also strongly similar FT to Mycobacterium tuberculosis probable sugar transferase FT Rv1516c." FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/Swiss-Prot:P64864" FT /protein_id="CAD96214.1" FT /translation="MSIVSISYNQEEYIREALDGFAAQRTEFPVEVIIADDASTDATPR FT IIGEYAARYPQLFRPILRQTNIGVHANFKDVLSAARGEYLALCEGDDYWTDPLKLSKQV FT KYLDRHPETTVCFHPVRVIYEDGAKDSEFPPLSWRRDLSVDALLARNFIQTNSVVYRRQ FT PSYDDIPANVMPIDWYLHVRHAVGGEIAMLPETMAVYRRHAHGIWHSAYTDRRKFWETR FT GHGMAATLEAMLDLVHGHREREAIVGEVSAWVLREIGKTPGRQGRALLLKSIADHPRMT FT MLSLQHRWAQTPWRRFKRRLSTELSSLAALAYATRRRALEGRDGGYRETTSPPTGRGRN FT VRGSHA" FT CDS 82315..84066 FT /transl_table=11 FT /gene="fadD25" FT /locus_tag="Mb1548" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD25 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1548, fadD25, len: 583 aa. Equivalent to Rv1521, FT len: 583 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 583 aa overlap). Probable fadD25, FT fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to FT many e.g. P71495|U75685 ACYL-CoA SYNTHASE from FT Mycobacterium bovis (582 aa), FASTA scores: opt: 2486, E(): FT 0, (63.4% identity in 584 aa overlap); FT NP_301232.1|NC_002677 acyl-CoA synthetase from FT Mycobacterium leprae (579 aa); etc. Also highly similar to FT others from Mycobacterium tuberculosis e.g. fadD24 (584 FT aa); fadD28 (580 aa); etc." FT /db_xref="GOA:Q7TZY1" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TZY1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96215.1" FT /translation="MSVVESSLPGVLRERASFQPNDKALTFIDYERSWDGVEETLTWSQ FT LYRRTLNLAAQLREHGSTGDRALILAPQILDYVVSFIASLQAGIVAVPLSIPQGGAHDE FT RTVSVFADTAPAIVLTASSVVDNVVEYVQPQPGQNAPAVIEVDRLDLDARPSSGSRSAA FT HGHPDILYLQYTSGSTRTPAGVMVSNKNLFANFEQIMTSYYGVYGKVAPPGSTVVSWLP FT FYHDMGFVLGLILPILAGIPAVLTSPIGFLQRPARWIQMLASNTLAFTAAPNFAFDLAS FT RKTKDEDMEGLDLGGVHGILNGSERVQPVTLKRFIDRFAPFNLDPKAIRPSYGMAEATV FT YVATRKAGQPPKIVQFDPQKLPDGQAERTESDGGTPLVSYGIVDTQLVRIVDPDTGIER FT PAGTIGEIWVHGDNVAIGYWQKPEATERTFSATIVNPSEGTPAGPWLRTGDSGFLSEGE FT LFIMGRIKDLLIVYGRNHSPDDIEATIQTISPGRCAAIAVSEHGAEKLVAIIELKKKDE FT SDDEAAERLGFVKREVTSAISKSHGLSVADLVLVSPGSIPITTSGKIRRAQCVELYRQD FT EFTRLDA" FT CDS complement(84302..87625) FT /transl_table=11 FT /gene="mmpL12" FT /locus_tag="Mb1549c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL12" FT /note="Mb1549c, mmpL12, len: 1107 aa. Equivalent to FT Rv1522c, len: 1146 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.7% identity in 1107 aa overlap). Probable FT mmpL12, conserved transmembrane transport protein (see FT first citation below), member of RND superfamily. Strong FT similarity to many Mycobacterial membrane proteins e.g. FT Q49619|G466786 putative transport protein B1170_C1_181 from FT Mycobacterium leprae (1008 aa), FASTA scores: opt: 2418, FT E(): 0, (51.0% identity in 1006 aa overlap); etc. Also FT highly similar to MmpL8|MTCY48.08c|Rv3823c PROBABLE FT CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from FT Mycobacterium tuberculosis, FASTA score: (34.3% identity in FT 376 aa overlap); and some similarity to FT MmpL10|MTCY20G9|Rv1183 PROBABLE CONSERVED TRANSMEMBRANE FT TRANSPORT PROTEIN, FASTA score: (27.2% identity in 1011 aa FT overlap). BELONGS TO THE MMPL FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT single base transversion (c-a) omitting a stop codon, leads FT to a shorter product compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (1107 aa versus FT 1146 aa)." FT /db_xref="GOA:Q7TZY0" FT /db_xref="InterPro:IPR000731" FT /db_xref="UniProtKB/TrEMBL:Q7TZY0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96216.1" FT /translation="MARHDEAKAGGLFDRIGNFVVRWPLIVIGCWIAVAAALTLLLPTL FT QAQAAKREQAPLPPGAPSMVLQKEMSAAFQEKIETSALLLVLLTNENGLGPADEAVYRK FT LIENLRADTQDKISVQDFLAVPEMKELLASKDNKAWNLPITFAGDAASPETQAAFKRVA FT AIVKQTVAGTSLTVHLSGPIATVADLTELGEKDVRIIEIGAAVSVLIILILVYRNLVTM FT LVPLATIGASVVTAQGTLSGLAEFGLAVNMQAIVFMSAVMIGAGTDYAVFLISRYHDYV FT RHGEKSDMAVKKALMSIGKVITASAATVAVTFLAMVFTKLEVFSAVGPAIAVAITVSLL FT GAVTLLPAILTLTGRRGWIKPRRDLTSRMWRRSGVRIVRRPTIHLVGSLIVLVALAGCT FT LLIRFNYDDLKTVPQHVESVKGYEAMNRHFPMNAMTPMVLFIKSPRDLRTPGALADIEM FT MSREIAELPNIVMVRGLTRPNGEPLKETKVSFQAGEVGGKLDEATTLLEEHGGELDQLT FT GGAHQLADALAQIRNEINGAVASSSGIVNTLQAMMDLMGGDKTIRQLENASQYVGRMRA FT LGDNLSGTVTDAEQIATWASPMVNALNSSPVCNSDPACRTSRAQLAAIVQAQDDGLLRS FT IRALAVTLQQTQEYQTLARTVSTLDGQLKQVVSTLKAVDGLPTKLAQMQQGANALADGS FT AALAAGVQELVDQVKKMGSGLNEAADFLLGIKRDADKPSMAGFNIPPQIFSRDEFKKGA FT QIFLSADGHAARYFVQSALNPATTEAMDQVNDILRVADSARPNTELEDATIGLAGVPTA FT LRDIRDYYNSDMKFIVIATIVIVFLILVILLRALVAPIYLIGSVLISYLSALGIGTLVF FT QLILGQEMHWSLPGLSFILLVAIGADYNMLLISRIRDESPHGIRIGVIRTVGSTGGVIT FT SAGLIFAASMFGLVGANINTMAQAGFTIGIGIVLDTFLVRTVTVPALTTMIGRANWWPS FT ELGRDPSTPPTKADRWLRRVKGHRRKAPIPAPKPPHTKVVRNTNGHASKAATKSVPNGK FT PADLAEGNGEYLIDHLRRHSLPLFGYAAMPAYDVVDGVSKPNGDGAHIGKEPVDHLLGH FT " FT CDS 87666..88709 FT /transl_table=11 FT /gene="Mb1550" FT /locus_tag="Mb1550" FT /product="Probable methyltransferase" FT /EC_number="2.1.1.-" FT /note="Mb1550, -, len: 347 aa. Equivalent to Rv1523, len: FT 347 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 347 aa overlap). Probable methyltransferase (EC FT 2.1.1.-), similar to G560513|U0002O Mycobacterium leprae FT (270 aa), FASTA scores: opt: 965, E(): 0, (60.3% identity FT in 247 aa overlap). Also similar to many e.g. Q54303|X86780 FT METHYLTRANSFERASE RAPM from Streptomyces hygroscopicus (317 FT aa), FASTA scores: opt: 323, E(): 1e-15, (41.2% identity in FT 136 aa overlap). And similar to Mycobacterium tuberculosis FT hypothetical proteins Rv2952, Rv1405c, Rv1403c, Rv0839. FT Start uncertain." FT /db_xref="GOA:Q7VEZ4" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q7VEZ4" FT /protein_id="CAD96217.1" FT /translation="MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRD FT AASEQIARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVGKLTT FT KYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLSESDEPNRYCIQLYHQTASQVDLTGKE FT VLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQGDAQNLPFP FT DESFDAVVNVEASHQYPDFRGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPL FT RTISQRDIGAQAKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRRGGGFSYR FT IYLFAKD" FT CDS 88739..89983 FT /transl_table=11 FT /gene="Mb1551" FT /locus_tag="Mb1551" FT /product="Probable glycosyltransferase" FT /EC_number="2.4.1.-" FT /note="Mb1551, -, len: 414 aa. Equivalent to Rv1524, len: FT 414 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 414 aa overlap). Probable glycosyltransferase FT (EC 2.4.1.-), similar to many e.g. P96559|U84349 FT GLYCOSYLTRANSFERASE GTFB from Amycolatopsis orientalis (407 FT aa), FASTA scores: opt: 363, E(): 6.2e-23, (28.8% identity FT in 430 aa overlap); also high similarity to FT Rv1526c|MTCY19G5.02 Mycobacterium tuberculosis hypothetical FT protein (58.7% identity in 416 aa overlap); and FT AF143772|AF143772_15 glycosyltransferase gtfB from FT Mycobacterium avium strain 215 (418 aa), FASTA scores: opt: FT 1801, E(): 0, (65.2% identity in 417 aa overlap)." FT /db_xref="GOA:P64866" FT /db_xref="InterPro:IPR004276" FT /db_xref="UniProtKB/Swiss-Prot:P64866" FT /protein_id="CAD96218.1" FT /translation="MKFVVASYGTRGDIEPCAAVGLELQRRGHDVCLAVPPNLIGFVET FT AGLSAVAYGSRDSQEQLDEQFLHNAWKLQNPIKLLREAMAPVTEGWAELSAMLTPVAAG FT ADLLLTGQIYQEVVANVAEHHGIPLAALHFYPVRANGEIAFPARLPAPLVRSTITAIDW FT LYWRMTKGVEDAQRRELGLPKASTPAPRRMAVRGSLEIQAYDALCFPGLAAEWGGRRPF FT VGALTMESATDADDEVASWIAADTPPIYFGFGSMPIGSLADRVAMISAACAELGERALI FT CSGPSDATGIPQFDHVKVVRVVSHAAVFPTCRAVVHHGGAGTTAAGLRAGIPTLILWVT FT SDQPIWAAQIKQLKVGRGRRFSSATKESLIADLRTILAPDYVTRAREIASRMTKPAASV FT TATADLLEDAARRAR" FT CDS 90030..90815 FT /transl_table=11 FT /gene="wbbL2" FT /locus_tag="Mb1552" FT /product="POSSIBLE RHAMNOSYL TRANSFERASE WBBL2" FT /EC_number="2.-.-.-" FT /note="Mb1552, wbbL2, len: 261 aa. Equivalent to Rv1525, FT len: 261 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 261 aa overlap). Possible wbbL2, FT rhamnosyl transferase (EC 2.-.-.-), showing weak similarity FT to several rhamnosyl transferases. Similar to FT AF105060|AF105060_1 Riftia pachyptila endosymbiont (746 FT aa), FASTA scores: opt: 183, E(): 0.00013, (35.2% identity FT in 105 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64868" FT /protein_id="CAD96219.1" FT /translation="MYAPLVSLMITVPVFGQHEYTHALVADLEREGADYLIVDNRGDYP FT RIGTERVSTPGENLGWAGGSELGFRLAFAEGYSHAMTLNNDTRVSKGFVAALLDSRLPA FT DAGMVGPMFDVGFPFAVADEKPDAESYVPRARYRKVPAVEGTALVMSRDCWDAVGGMDL FT STFGRYGWGLDLDLALRARKSGYGLYTTEMAYINHFGRKTANTHFGGHRYHWGASAAMI FT RGLRRTHGWPAAMGILREMGMAHHRKWHKSFPLTCPASC" FT CDS complement(90793..92073) FT /transl_table=11 FT /gene="Mb1553c" FT /locus_tag="Mb1553c" FT /product="Probable glycosyltransferase" FT /EC_number="2.4.1.-" FT /note="Mb1553c, -, len: 426 aa. Equivalent to Rv0526c, len: FT 426 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 426 aa overlap). Probable glycosyltransferase FT (EC 2.4.1.-), highly similar to G467196 Protein L518_C2_147 FT from Mycobacterium leprae (421 aa), FASTA scores, opt: FT 1497, E(): 0, (55.0% identity in 424 aa overlap); similar FT to G452504 rhamnosyltransferase (24.7% identity in 433 aa FT overlap); and P96565|U84350 GLYCOSYLTRANSFERASE GTFE from FT Amycolatopsis orientalis (408 aa), E(): 3.4e-24, (28.4% FT identity in 429 aa overlap), also high similarity to FT Rv1524|MTCY19G5.04c (58.7 % identity in 416 aa overlap)." FT /db_xref="GOA:P64870" FT /db_xref="InterPro:IPR004276" FT /db_xref="UniProtKB/Swiss-Prot:P64870" FT /protein_id="CAD96220.1" FT /translation="MKFVLAVHGTRGDVEPCAAVGVELRRRGHAVHMAVPPNLIEFVES FT AGLTGVAYGPDSDEQINTVAAFVRNLTRAQNPLNLARAVKELFVEGWAEMGTTLTTLAD FT GADLVMTGQTYHGVAANVAEYYDIPAAALHHFPMQVNGQIAIPSIPTPATLVRATMKVS FT WRLYAYVSKDADRAQRRELGLPPAPAPAVRRLAERGAPEIQAYDPVFFPGLAAEWSDRR FT PFVGPLTMELHSEPNEELESWIAAGTPPIYFGFGSTPVQTPVQTLAMISDVCAQLGERA FT LIYSPAANSTRIRHADHVKRVGLVNYSTILPKCRAVVHHGGAGTTAAGLRAGMPTLILW FT DVADQPIWAGAVQRLKVGSAKRFTNITRGSLLKELRSILAPECAARAREISTRMTRPTA FT AVTAAADLLEATARQTPGSTPSSSPGR" FT CDS complement(92096..98422) FT /transl_table=11 FT /gene="pks5" FT /locus_tag="Mb1554c" FT /product="Probable polyketide synthase pks5" FT /note="Mb1554c, pks5, len: 2108 aa. Equivalent to Rv1527c, FT len: 2108 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 2108 aa overlap). Probable pks5, FT polyketide synthase, highly similar to many e.g. FT MCAS_MYCBO|Q02251 mycocerosic acid synthase from FT Mycobacterium bovis (2110 aa), FASTA scores: opt: 6270, FT E(): 0, (63.6% identity in 2126 aa overlap)." FT /db_xref="GOA:Q7VEZ3" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7VEZ3" FT /protein_id="CAD96221.1" FT /translation="MGKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRLWEALLRGDD FT LVTEIPADRWDIDEYYDPEPGVPGRTDCKWGAYLDNVGDFDPEFFGIGEKEAIAIDPQH FT RLLLETSWEAMEHGGLTPNQMASRTGVFVGLVHTDYILVHADNQTFEGPYGNTGTNACF FT ASGRVAYAMGLQGPAITVDTACSSGLTAIHLACRSLHDGESDIALAGGVYVMLEPRRFA FT SGSALGMLSATGRCHAFDVSADGFVSGEGCVMLALKRLPDALADGDRILAVIRGTAANQ FT DGHTVNIATPSRSAQVAAYREALDVAGVDPATVGMVEAHGPGTPVGDPIEYASLAEVYG FT NDGPCALASVKTNFGHTQSAAGALGLMKAVLALQHGVVPQNLHFTALPDKLAAIETNLF FT VPQEITPWPGADQETPRRAAVSSYGMTGTNVHAIVEQAPVPAPESGAPGDTPATPGIDG FT ALLFALSASSQDALRQTAARLADWVDAQGPELAPADLAYTLARRRGHRPVRTAVLAATT FT AELTEALREVATGETPYPPAVGQDDRGPVWVFSGQGSQWAGMGADLLATEPVFAATIAA FT IEPLIAAESGFSVTEAMTAPEVVTGIDRVQPTLFAMQVALAATMKSYGVAPGAVIGHSL FT GESAAAVVAGALCLEDGVRVICRRSALMTRIAGAGAMASVELPAQQVLSELMARGVNDA FT VVAVVASPQSTVIGGATQTVRDLVAAWEQRDVLAREVAVDVASHSPQVDPILDELAEAL FT AEISPLQPEIPYYSATSFDPREEPYCDAYYWVDNLRHTVRFAAAVQAALEDGYRVFTEL FT TPHPLLTHAVDQTARSLDMSAAALAGMRREQPLPHGLRALAGDLYAAGAAVDFAVLYPT FT GRLINAPLPTWNHRRLLLDDTTRRIAHANTVAVHPLLGSHVRLPEEPERHVWQGEVGTV FT TQPWLADHQIHGAAALPGAAYCEMALAAARAVLGEASEVRDIRFEQMLLLDDETPIGVT FT ATVEAPGVVPLTVETSHDGRYTRQLAAVLHVVREADDAPDQPPQKNIAELLASHPHKVD FT GAEVRQWLDKRGHRLGPAFAGLVDAYIAEGAGDTVLAEVNLPGPLRSQVKAYGVHPVLL FT DACFQSVAAHPAVQGMADGGLLLPLGVRRLRSYGSARHARYCCTTVTACGVGVEADLDV FT LDEHGAVVLAVRGLQLGTGASQASERARVLGERLLSIEWHERELPENSHAEPGAWLLIS FT TCDATDLVAAQLTDALKVHDAQCTTMSWPQRADHAAQAARLRDQLGTGGFTGVFVLTAP FT QTGDPDAESPVRGGELVKHVVRIAREIPEITAQEPRLYVLTHNAQAVLSGDRPNLEQGG FT MRGLLRVIGAEHPHLKASYVDVDEQTGAESVARQLLAASGEDETAWRNDQWYTARLCPA FT PLRPEERQTTVVDHAEAGMRLQIRTPGDLQTLEFAALDRVPPGPGEIEVAVTASSINFA FT DVLVTFGRYQTLDGRQPQLGTDFAGVVSAVGPGVSELKVGDRVGGMSPNGCWATFVTCD FT ARLATRLPEGLTDAQAAAVTTASATAWYGLQDLARIKAGDKVLIHSATGGVGQAAIAIA FT RAAGAQIYATAGNEKRRDLLRDMGIEHVYDSRSVEFAEQIRRDTAGYGVDIVLNSVTGA FT AQLAGLKLLALGGRFIEIGKRDIYSNTRLELLPFRRNLAFYGLDLGLMSVSHPAAVREL FT LSTVYRLTVEGVLPMPQSTHYPLAEAATAIRVMGAAEHTGKLILDVPHAGRSSVVLPPE FT QARVFRSDGSYIITGGLGGLGLFLAEKMANAGAGRIVLSSRSQPSQKALETIELVRAIG FT SDVVVECGDIAQPDTADRLVTAATATGLPLRGVLHAAAVVEDATLANITDELIERDWAP FT KAYGAWQLHRATADQPLDWFCSFSSAAALVGSPGQGAYAAANSWLDTFTHWRRAQDLPA FT TSIAWGAWGQIGRAIAFAEQTGDAIAPEEGAYAFETLLRHNRAYSGYAPVIGSPWLTAF FT AQHSPFAEKFQSLGQNRSGTSKFLAELVDLPREEWPDRLRRLLSKQVGLILRRTIDTDR FT LLSEYGLDSLSSQELRARVEAETGIRISATEINTTVRGLADLMCDKLAADRDAPAPA" FT CDS complement(98966..99463) FT /transl_table=11 FT /gene="papA4" FT /locus_tag="Mb1555c" FT /product="PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED FT PROTEIN PAPA4" FT /note="Mb1555c, papA4, len: 165 aa. Equivalent to Rv1528c, FT len: 165 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 165 aa overlap). Probable papA4, FT conserved polyketide synthase (PKS) associated protein; FT shows some similarity to C-terminal part of hypothetical FT proteins from Mycobacterium tuberculosis and Mycobacterium FT leprae e.g. Z97188|MTCY409_10 Mycobacterium tuberculosis FT cosmid (468) (37.9% identity in 66 aa overlap); or FT U00010_11 Mycobacterium leprae cosmid B1170 (35.7% identity FT in 84 aa overlap). Also similar to Mycobacterium FT tuberculosis PKS-associated proteins Rv1182, Rv3824c, FT Rv3820c." FT /db_xref="UniProtKB/TrEMBL:Q7TZX9" FT /protein_id="CAD96222.1" FT /translation="MTQLPQPTWRWWQQRETEQVQSSHIDGEIVGALIPDLAVLHSEDA FT SRAAVGREKHRCSLDPLGGGFRSRRASMPAGALLLSAVIAIQLDRMNARVFGDGWIGAQ FT ACMWVNKFHEESTVTALSPSSPIAQGSIARHPETMQSAYVRIAEGGSRDVAPAAQLQRR FT RP" FT CDS 99515..101269 FT /transl_table=11 FT /gene="fadD24" FT /locus_tag="Mb1556" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD24 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1556, fadD24, len: 584 aa. Equivalent to Rv1529, FT len: 584 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 584 aa overlap). Probable fadD24, FT fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to FT many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase FT from Mycobacterium bovis (582 aa), FASTA score: (65.6% FT identity in 582 aa overlap); and many other fatty-acid-CoA FT synthetases from Mycobacteria e.g. fadD25|MTCY19G5_7 from FT Mycobacterium tuberculosis (583 aa), FASTA score: (68.7% FT identity in 584 aa overlap); fadD28|MTCY24G1_8 from FT Mycobacterium tuberculosis (580 aa), FASTA score: (66.0% FT identity in 582 aa overlap); NP_301232.1|NC_002677|U00010_6 FT from Mycobacterium leprae (372 aa), FASTA score: (57.6% FT identity in 342 aa overlap); FADD23|Rv3826|MTCY409.04c from FT Mycobacterium tuberculosis (584 aa), FASTA score: (63.2% FT identity in 584 aa overlap); etc." FT /db_xref="GOA:Q7TZX8" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TZX8" FT /protein_id="CAD96223.1" FT /translation="MVASSIPTALRERASVHPNGAAITYIDYEQDWAGVAETLTWSQLY FT RRMLNVAEPLRHVGATGDRAVILAPQGIEYVVGFLGALQAGRIAVPLPVPHAGAHDERT FT ISVLSDTSPAVILTTSGAVDDVRECAQPQPGQSAPSIVELDLLDLDSRQRSRSPGARPT FT GRDTPETAYLQYTSGSTRTPAGVMVSNKNVFANFEQIVADFFAPEGGVVPPDLTVVSWL FT PLYHDMGLLLGAIMPILAGVPTVLTSPVGFLQRPARWIQLLARNGRTISAGPNFAFELA FT VRKTSDDDMDGLDLAGVHTILNGSERVHPATLKRFAERFGRFNFAAAALRPAYGMAEAT FT VYIATRNVNEPPEIVDFESEKLPAGQAIRCPSGSGTPLVSYGVPRSQLVRIVDPDTCIE FT CPQGSVGEIWVQGGNVASGYWHKPEESKRTFGARIVTPSAGTPEAPWLRTGDSGFVSGG FT ELFIIGRIKDLLIVYGRNHAPDDIEATIQEITSGRCAAIAVPDHGTEKLVAIIELKKRG FT DSDEDVADRLRIVKRDVAAAIFDSHGLSVADLVLVSPGSIPITTSGKIRRAQCVQLYRR FT REFTRLDA" FT CDS 101386..102489 FT /transl_table=11 FT /gene="adh" FT /locus_tag="Mb1557" FT /product="Probable alcohol dehydrogenase adh" FT /EC_number="1.1.1.1" FT /note="Mb1557, adh, len: 367 aa. Equivalent to Rv1530, len: FT 367 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 367 aa overlap). Probable adh, alcohol FT dehydrogenase (EC 1.1.1.1), zinc-dependent, similar to many FT e.g. AE0009|AE000958_23 Archaeoglobus fulgidus section 1 FT (402 aa), FASTA scores: opt: 423, E(): 1.8e-19, (31.7% FT identity in 341 aa overlap). Contains PS00059 FT Zinc-containing alcohol dehydrogenases signature." FT /db_xref="GOA:Q7VEZ2" FT /db_xref="InterPro:IPR013154" FT /db_xref="UniProtKB/TrEMBL:Q7VEZ2" FT /protein_id="CAD96224.1" FT /translation="MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGT FT DHEQYTGELAGGFAFVPGHETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCRQCANCR FT GGEYRRCVRHGLADMYGFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFN FT PLGAGIRWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLA FT LAAQFGADLAVDVAIDDPVAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVV FT AGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAALDLLVSGRYPFASLPRRCVR FT LEGAEDLLATMAGERDGVPPIHGVLTP" FT CDS 102486..103052 FT /transl_table=11 FT /gene="Mb1558" FT /locus_tag="Mb1558" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1558, -, len: 188 aa. Equivalent to Rv1531, len: FT 188 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 188 aa overlap). Conserved hypothetical FT protein, similar to Rv0464c|MTV038.08c (190 aa), FASTA FT scores: E(): 4.8e-10, (30.9% identity in 175 aa overlap)." FT /db_xref="InterPro:IPR003779" FT /db_xref="UniProtKB/TrEMBL:Q7TZX7" FT /protein_id="CAD96225.1" FT /translation="MTTSRVPLLPVDEAKAAADEAGVPDYMAELSIFQVLLNHPRLART FT FNDLLATMLWHGTLDSRLRELVIMRIGWLTDCDYEWTQHWRVASGLGVSADDLLGVRDW FT QGYNGFGPAEQAVLAATDDVVREGAVSAQSWSACERELHCDKVVLIELVTVISAWRMVA FT SILHSLEVPLEDGVSSWPPDGLSPR" FT CDS complement(103129..103563) FT /transl_table=11 FT /gene="Mb1559c" FT /locus_tag="Mb1559c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1559c, -, len: 144 aa. Equivalent to Rv1532c, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 144 aa overlap). Conserved hypothetical FT protein, similar to P20378|YPHR_HALHA Hypothetical 15.6 kd FT protein from Halobacterium halobium (151 aa), FASTA scores: FT opt: 152, E():4.5e-05, (30.1% identity in 103 aa overlap)." FT /db_xref="InterPro:IPR003736" FT /db_xref="UniProtKB/TrEMBL:Q7TZX6" FT /protein_id="CAD96226.1" FT /translation="MSDPLTAQEQHKRRQAVRELMPRTPFIGGLGIVFERYEPDDVVIR FT LPFRTDLTNDGTYFHGGVIASVMDTAGAAAAWSNHDFDRGTRAATVAMSIQYTGAAKRC FT DLLCHARTARRRKELTFTEITATDPDGNIVAHAVQTYRIV" FT CDS 103623..104750 FT /transl_table=11 FT /gene="Mb1560" FT /locus_tag="Mb1560" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1560, -, len: 375 aa. Equivalent to Rv1533, len: FT 375 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 375 aa overlap). Conserved hypothetical FT protein. Similar to 2NPD_NEUCR|Q01284 2-nitropropane FT dioxygenase precursor (378 aa), fasta scores: opt: 279, FT E(): 9.1e-11, (31.3% identity in 256 aa overlap). Also FT similar to Mycobacterium tuberculosis hypothetical proteins FT Rv1894c, Rv0021c, Rv3553, Rv2781c." FT /db_xref="GOA:Q7TZX5" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:Q7TZX5" FT /protein_id="CAD96227.1" FT /translation="MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPK FT RLESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQARELIPEGHRTFVDDLLVR FT YGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHDIRLIASALGPPPPDLVERAHNHD FT VLVAALAGTAQHARRHAAAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAVSPTPVLAA FT GGIARGRQIAAALALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGK FT PARMLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQ FT VVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR" FT CDS 104747..105424 FT /transl_table=11 FT /gene="Mb1561" FT /locus_tag="Mb1561" FT /product="Probable transcriptional regulator" FT /note="Mb1561, -, len: 225 aa. Equivalent to Rv1534, len: FT 225 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 225 aa overlap). Probable transcriptional FT regulator, similar to YCDC_ECOLI|P75899 hypothetical FT transcriptional regulator from Escherichia coli (212 aa), FT FASTA scores: opt: 166, E(): 9.8e-05, (24.2% identity in FT 219 aa overlap). Contains PS01081 Bacterial regulatory FT proteins, tetR family signature and helix turn helix motif FT (aa 41-62)." FT /db_xref="GOA:Q7VEZ1" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7VEZ1" FT /protein_id="CAD96228.1" FT /translation="MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVADI FT AKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRALLQAA FT VQATFEFFETDKATVKLLFRDAYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVE FT APSRMAAYTLAALVGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRA FT ART" FT CDS 105989..106225 FT /transl_table=11 FT /gene="Mb1562" FT /locus_tag="Mb1562" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1562, -, len: 78 aa. Equivalent to Rv1535, len: 78 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 78 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZX4" FT /protein_id="CAD96229.1" FT /translation="MTAALHNDVVTVASAPKLRVVRDVPPAPASKKVARRLDAQPFGTG FT GDPLVDGAARLLSIPLRHLYAALWRVGLLEVQA" FT CDS 106532..109657 FT /transl_table=11 FT /gene="ileS" FT /locus_tag="Mb1563" FT /product="isoleucyl-tRNA synthetase ileS" FT /EC_number="6.1.1.5" FT /note="Mb1563, ileS, len: 1041 aa. Equivalent to Rv1536, FT len: 1041 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1041 aa overlap). ileS, Isoleucyl-tRNA FT synthetase (EC 6.1.1.5) , similar to several e.g. FT SYIC_YEAST P09436 isoleucyl-tRNA synthetase (1072 aa), FT FASTA scores: opt: 1447, E(): 0, (37.8% identity in 1072 aa FT overlap); contains PS00178 Aminoacyl-transfer RNA FT synthetases class-I signature. BELONGS TO CLASS-I FT AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:Q7VEZ0" FT /db_xref="HSSP:1ILE" FT /db_xref="InterPro:IPR013155" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEZ0" FT /protein_id="CAD96230.1" FT /translation="MTDNAYPKLAGGAPDLPALELEVLDYWSRDDTFRASIARRDGAPE FT YVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQ FT LGITDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMES FT VIWAFKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTVGFKVVG FT GQPDNGLDGAYLLVWTTTPWTLPSNLAVAVSPDITYVQVQAGDRRFVLAEARLAAYARE FT LGEEPVVLGTYRGAELLGTRYLPPFAYFMDWPNAFQVLAGDFVTTDDGTGIVHMAPAYG FT EDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSGPAAVNGP FT VLIRHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHVKDGQ FT FGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDELERDFGVRPANLHRP FT YIDELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMPYAQVHYPFENLDWFQGHYPGDFI FT VEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFD FT RDGSDAMRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPLWNTYSFLALYAPKVGTWRV FT DSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALTNWYVRRSRSRFWAE FT DADAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTRERSVHLTDWPAPDLLPSDADLVA FT AMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAVENPQLLRPFVDLIGDELNVKQVELT FT DAIDTYGRFELTVNARVAGPRLGKDVQAAIKAVKAGDGVINPDGTLLAGPAVLTADEYN FT SRLVAADPESTAALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLDVSDRI FT RVVMSVPAEREDWARTHRDLIAGEILATDFEFADLADGVAIGDGVRVSIEKT" FT CDS 109869..111260 FT /transl_table=11 FT /gene="dinX" FT /locus_tag="Mb1564" FT /product="Probable DNA polymerase IV dinX" FT /note="Mb1564, dinX, len: 463 aa. Equivalent to Rv1537, FT len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 463 aa overlap). Probable dinX, DNA FT polymerase IV. Similar to umuC, mucB, samb, and impb (uv FT protection and mutation) e.g. IMPB_SALTY|P18642 impb FT protein from Salmonella typhimurium (424 aa), FASTA scores, FT opt: 386, E(): 1.7e-17, (27.5% identity in 415 aa overlap). FT Also similar to Mycobacterium tuberculosis Rv3056." FT /db_xref="GOA:P63986" FT /db_xref="HSSP:1JX4" FT /db_xref="InterPro:IPR001126" FT /db_xref="UniProtKB/Swiss-Prot:P63986" FT /protein_id="CAD96231.1" FT /translation="MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEAR FT AYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFA FT EPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVR FT HAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALH FT RLARGIDDRPVVERAEAKQISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGAR FT TITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSD FT IRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGH FT GVVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVD FT DVGDR" FT CDS complement(111225..112205) FT /transl_table=11 FT /gene="ansA" FT /locus_tag="Mb1565c" FT /product="Probable L-aparaginase ansA" FT /EC_number="3.5.1.1" FT /note="Mb1565c, ansA, len: 326 aa. Equivalent to Rv1538c, FT len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 326 aa overlap). Probable ansA, FT L-aparaginase, most similar to ASPG_BACLI|P30363 FT L-asparaginase (322 aa), FASTA scores: opt: 417, E(): FT 8.8e-19, (30.9% identity in 314 aa overlap). Contains FT PS00917 Asparaginase / glutaminase active site signature FT 2." FT /db_xref="GOA:P63628" FT /db_xref="HSSP:3PGA" FT /db_xref="InterPro:IPR006034" FT /db_xref="UniProtKB/Swiss-Prot:P63628" FT /protein_id="CAD96232.1" FT /translation="MGANHVRNDPIMARLTVITTGGTISTTAGPDGVLRPTHCGATLIA FT GLDMDSDIEVVDLMALDSSKLTPADWDRIGAAVQEAFRGGADGVVITHGTDTLEETALW FT LDLTYAGSRPVVLTGAMLSADAPGADGPANLRDALAVAADPAARDLGVLVSFGGRVLQP FT LGLHKVANPDLCGFAGESLGFTSGGVRLTRTKTRPYLGDLGAAVAPRVDIVAVYPGSDA FT VAMDACVAAGARAVVLEALGSGNAGAAVIEGVRRHCRDGSDPVVIAVSTRVAGARVGAG FT YGPGHDLVEAGAVMVPRLPPSQARVLLMAALAANSPVADVIDRWG" FT CDS 112257..112865 FT /transl_table=11 FT /gene="lspA" FT /locus_tag="Mb1566" FT /product="Probable lipoprotein signal peptidase lspA" FT /EC_number="3.4.23.36" FT /note="Mb1566, lspA, len: 202 aa. Equivalent to Rv1539, FT len: 202 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 202 aa overlap). Probable lspA, FT lipoprotein signal peptidase (EC 3.4.23.36), similar to FT several e.g. LSPA_PSEFL|P17942 (170 aa), FASTA scores: opt: FT 299, E(): 2.6e-12, (38.3% identity in 167 aa overlap)." FT /db_xref="GOA:P65263" FT /db_xref="InterPro:IPR001872" FT /db_xref="UniProtKB/Swiss-Prot:P65263" FT /protein_id="CAD96233.1" FT /translation="MPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLT FT LDIVTKVVAVQLLPPGQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVVGI FT FWMGRRLVSPWWALGLGMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNVADP FT SVVGGAILLVILSIFGFDFDTVGRRHADGDTVGRRKADG" FT CDS 112858..113784 FT /transl_table=11 FT /gene="Mb1567" FT /locus_tag="Mb1567" FT /product="CONSERVED HYPOTHETICAL PROTEIN MEMBER OF FT yabO/yceC/yfiI FAMILY" FT /note="Mb1567, -, len: 308 aa. Equivalent to Rv1540, len: FT 308 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 308 aa overlap). Member of the yabO/yceC/yfiI FT family of hypothetical proteins, similar to FT P44445|YFII_HAEIN hypothetical protein HI0176 from FT Haemophilus influenzae (324 aa), FASTA scores: opt: 437, FT E(): 1.2e-22, (33.2% identity in 322 aa overlap). FT Equivalent to AL049478|MLCL458_13 hypothetical protein from FT Mycobacterium leprae (308 aa), (89.3% identity in 307 aa FT overlap). Contains PS01129 hypothetical yabO/yceC/yfiI FT family signature." FT /db_xref="GOA:P0A5T3" FT /db_xref="InterPro:IPR002942" FT /db_xref="UniProtKB/Swiss-Prot:P0A5T3" FT /protein_id="CAD96234.1" FT /translation="MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELNG FT VPAGKSDRLVSGALLQVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAVAAHAS FT VGWTGPTVLGGLAAAGYRITTSGVHERQGIVHRLDVGTSGVMVVAISERAYTVLKRAFK FT YRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEWKFAITKNGRHSLTHYDTLEAFVAA FT SLLDVHLETGRTHQIRVHFAALHHPCCGDLVYGADPKLAKRLGLDRQWLHARSLAFAHP FT ADGRRVEIVSPYPADLQHALKILRGEG" FT CDS complement(113791..114384) FT /transl_table=11 FT /gene="lprI" FT /locus_tag="Mb1568c" FT /product="Possible lipoprotein lprI" FT /note="Mb1568c, lprI, len: 197 aa. Equivalent to Rv1541c, FT len: 197 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 197 aa overlap). Possible lipoprotein FT lprI, contains appropriately positioned prokaryotic FT membrane lipoprotein lipid attachment site (PS0013)." FT /db_xref="GOA:P65319" FT /db_xref="InterPro:IPR018660" FT /db_xref="UniProtKB/Swiss-Prot:P65319" FT /protein_id="CAD96235.1" FT /translation="MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQL FT VCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQ FT TRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELS FT GSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS" FT CDS complement(114439..114849) FT /transl_table=11 FT /gene="glbN" FT /locus_tag="Mb1569c" FT /product="Probable hemoglobin glbN" FT /note="Mb1569c, glbN, len: 136 aa. Equivalent to Rv1542c, FT len: 136 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 136 aa overlap). Probable glbN, FT hemoglobin. Belongs to the protozoan/cyanobacterial globin FT family. Similar to myoglobins e.g. GLB_PARCA|P15160 FT myoglobin (hemoglobin) paramecium (116 aa), FASTA scores, FT opt: 284, E(): 2.1e -13, (35.7% identity in 115 aa FT overlap). Similar to Mycobacterium tuberculosis FT hypothetical globin, Rv2470." FT /db_xref="GOA:P0A593" FT /db_xref="InterPro:IPR016339" FT /db_xref="UniProtKB/Swiss-Prot:P0A593" FT /protein_id="CAD96236.1" FT /translation="MGLLSRLRKREPISIYDKIGGHEAIEVVVEDFYVRVLADDQLSAF FT FSGTNMSRLKGKQVEFFAAALGGPEPYTGAPMKQVHQGRGITMHHFSLVAGHLADALTA FT AGVPSETITEILGVIAPLAVDVTSGESTTAPV" FT CDS 115077..116102 FT /transl_table=11 FT /gene="Mb1570" FT /locus_tag="Mb1570" FT /product="POSSIBLE FATTY ACYL-COA REDUCTASE" FT /EC_number="1.2.1.-" FT /note="Mb1570, -, len: 341 aa. Equivalent to Rv1543, len: FT 341 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 341 aa overlap). Possible fatty-acyl CoA FT reductase (EC 1.2.1.-), highly similar to P94129|U77680 FT FATTY ACYL-COA REDUCTASE ACR1 from Acinetobacter FT calcoaceticus (295 aa), FASTA scores: opt: 899, E(): 0, FT (48.5% identity in 293 aa overlap). Also highly similar to FT acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty acyl-CoA FT reductase from Mycobacterium tuberculosis (650 aa). Also FT highly similar to many oxidoreductases short-chain family." FT /db_xref="GOA:P66780" FT /db_xref="HSSP:1FDW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P66780" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96237.1" FT /translation="MNLGDLTNFVEKPLAAVSNIVNTPNSAGRYRPFYLRNLLDAVQGR FT NLNDAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVARTLENLENVANDIRAIRGNG FT GTAHVYPCDLSDMDAIAVMADQVLGDLGGVDILINNAGRSIRRSLELSYDRIHDYQRTM FT QLNYLGAVQLILKFIPGMRERHFGHIVNVSSVGVQTRAPRFGAYIASKAALDSLCDALQ FT AETVHDNVRFTTVHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPF FT GQFAAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSETFVRATRGIH FT W" FT CDS 116107..116910 FT /transl_table=11 FT /gene="Mb1571" FT /locus_tag="Mb1571" FT /product="Possible ketoacyl reductase" FT /EC_number="1.3.1.-" FT /note="Mb1571, -, len: 267 aa. Equivalent to Rv1544, len: FT 267 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 267 aa overlap). Possible ketoacyl reductase FT (EC 1.3.1.-), highly similar to Z97179|MLCL383_26 putative FT oxidoreductase from Mycobacterium leprae (268 aa), FASTA FT score: (43.0% identity in 270 aa overlap). Also highly FT similar to others e.g. T29125 ketoacyl reductase homolog FT from Streptomyces coelicolor (276 aa); FT NP_470957.1|NC_003212 protein similar to ketoacyl FT reductases from Listeria innocua (253 aa); FT HETN_ANASP|P37694 ketoacyl reductase from Anabaena sp. FT strain PCC 7120 (287 aa), FASTA scores: opt: 379, E(): FT 7.5e-18, (31.6% identity in 250 aa overlap); etc. And FT highly similar to many oxidoreductases short-chain family. FT Also highly similar to Rv2509 from Mycobacterium FT tuberculosis (268 aa). Contains PS00061 Short-chain alcohol FT dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7VEY9" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7VEY9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96238.1" FT /translation="MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRER FT LDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGLCNSAGFGTSGRFWEL FT PFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAGFQPIPYMAVYSATKAF FT VLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIASAERFSIPLAQVSPHDVAEAAIAG FT MLSGKRTVVPGIVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR" FT CDS 116932..117159 FT /transl_table=11 FT /gene="Mb1572" FT /locus_tag="Mb1572" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1572, -, len: 75 aa. Equivalent to Rv1545, len: 75 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 75 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64872" FT /protein_id="CAD96239.1" FT /translation="MPNGVLGLGNPSRLAALYGLQLAHESQCCQMHNLPSAARQVTVAC FT REEVGITTILAGRDECGVCDKTAGLDGAAP" FT CDS 117208..117639 FT /transl_table=11 FT /gene="Mb1573" FT /locus_tag="Mb1573" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1573, -, len: 143 aa. Equivalent to Rv1546, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 143 aa overlap). Conserved hypothetical FT protein, similar to O05902|Rv0910|MTCY21C12.04 Hypothetical FT protein from Mycobacterium tuberculosis (144 aa), FASTA FT scores: E(): 5e-30, (37.3% identity in 142 aa overlap)." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/Swiss-Prot:P64874" FT /protein_id="CAD96240.1" FT /translation="MASVELSADVPISPQDTWDHVSELSELGEWLVIHEGWRSELPDQL FT GEGVQIVGVARAMGMRNRVTWRVTKWDPPHEVAMTGSGKGGTKYGVTLTVRPTKGGSAL FT GLRLELGGRALFGPLGSAAARAVKGDVEKSLKQFAELYG" FT CDS 117707..121261 FT /transl_table=11 FT /gene="dnaE1" FT /locus_tag="Mb1574" FT /product="Probable DNA polymerase III (alpha chain) dnaE1" FT /EC_number="2.7.7.7" FT /note="Mb1574, dnaE1, len: 1184 aa. Equivalent to Rv1547, FT len: 1184 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 1184 aa overlap). Probable dnaE1, DNA FT polymerase III, alpha chain (EC 2.7.7.7), similar to e.g. FT DP3A_ECOLI|P10443 dna polymerase III, alpha chain (1160 FT aa), FASTA scores: opt: 1789, E(): 0, (36.5% identity in FT 1193 aa overlap). Also similar to M. tuberculosis, FT DnaE2|Rv3370c." FT /db_xref="GOA:P63978" FT /db_xref="InterPro:IPR004805" FT /db_xref="UniProtKB/Swiss-Prot:P63978" FT /protein_id="CAD96241.1" FT /translation="MSGSSAGSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGM FT TDHGNMFGASEFYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQKADDVSGSGS FT YTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELIAEHAEGIIITTGCPSGEV FT QTRLRLGQDREALEAAAKWREIVGPDNYFLELMDHGLTIERRVRDGLLEIGRALNIPPL FT ATNDCHYVTRDAAHNHEALLCVQTGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVPG FT ACDSTLLIAERVQSYADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGLRRRFPAGPPDG FT YRERAAYEIDVICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLVAYALGITDI FT DPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKT FT KAALKDSARIHYGQPGFAIADRITKALPPAIMAKDIPLSGITDPSHERYKEAAEVRGLI FT ETDPDVRTIYQTARGLEGLIRNAGVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYP FT ACEAIGLLKMDFLGLRNLTIIGDAIDNVRANRGIDLDLESVPLDDKATYELLGRGDTLG FT VFQLDGGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADRKNNRQAIKPIHP FT ELEEPLREILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMGKKKREVLEKEFEG FT FSDGMQANGFSPAAIKALWDTILPFADYAFNKSHAAGYGMVSYWTAYLKANYPAEYMAG FT LLTSVGDDKDKAAVYLADCRKLGITVLPPDVNESGLNFASVGQDIRYGLGAVRNVGANV FT VGSLLQTRNDKGKFTDFSDYLNKIDISACNKKVTESLIKAGAFDSLGHARKGLFLVHSD FT AVDSVLGTKKAEALGQFDLFGSNDDGTGTADPVFTIKVPDDEWEDKHKLALEREMLGLY FT VSGHPLNGVAHLLAAQVDTAIPAILDGDVPNDAQVRVGGILASVNRRVNKNGMPWASAQ FT LEDLTGGIEVMFFPHTYSSYGADIVDDAVVLVNAKVAVRDDRIALIANDLTVPDFSNAE FT VERPLAVSLPTRQCTFDKVSALKQVLARHPGTSQVHLRLISGDRITTLALDQSLRVTPS FT PALMGDLKELLGPGCLGS" FT CDS complement(121310..123346) FT /transl_table=11 FT /gene="PPE21" FT /locus_tag="Mb1575c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1575c, PPE21, len: 678 aa. Equivalent to Rv1548c, FT len: 678 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 678 aa overlap). Member of the M. FT tuberculosis PPE family, similar to several e.g. FT YHS6_MYCTU|P42611 hypothetical 50.6 kd protein in hsp65 3' FT region (517 aa), FASTA scores: opt:1142, E(): 0, (40.6% FT identity in 616 aa overlap); also similar to MTCY31.06c FT (54.9% identity in 381 aa overlap)." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7TZX3" FT /protein_id="CAD96242.1" FT /translation="MNFSVLPPEINSALMFAGAGPGPMLAAASAWTGLAGDLGSAAASF FT SAVTSQLATGSWQGPASAAMTGAAASYARWLTTAAAQAEQAAGQAQAAVSAFEAALAAT FT VHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVYEQMWAADVAAMLGYHGEASAVAL FT SLTPFTPSPSAAATPGGAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSANT FT GSVNLGNANIGDLNLGSGNIGSYNLGGGNTGDLNPGSGNTGTLNWGSGNIGSYNLGGGN FT LGSYNLGSGNTGDTNFGGGNTGNLNVGGGNTGNSNFGFGNTGNVNFGNGNTGDTNFGSG FT NLGSGNIGFGNKGSHNIGFGNSGNNNIGFGLTGDNQIGFGALNSGSGNLGFGNSGNGNI FT GFFNSGNNNIGMGNSGNGVGALSVEFGSSAERSSGFGNSGELSTGIGNSGQLSTGWFNS FT ATTSTGWFNSGTTNTGWFNSGTTNTGIGNSGGNLVTGSMGLFNSGHTNTGSFNAGSMNT FT GDFNSGNVNTGYFNSGNINTGFFNSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAG FT TFNSGFDNNARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSVPTITGTANISG FT FVNAGTSISGFFNFGSLMSGFANFDDEVSGYLNGDSRASGWIH" FT CDS 123503..125446 FT /transl_table=11 FT /gene="fadD11" FT /locus_tag="Mb1576" FT /product="POSSIBLE FATTY-ACID-COA LIGASE FADD11 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1576, fadD11, len: 647 aa. Equivalent to Rv1549 FT (fadD11') and Rv1550 (fadD11), len: 175 aa and 571 aa, from FT Mycobacterium tuberculosis strain H37Rv, (100% identity in FT 167 aa overlap and 99.8% identity in 470 aa overlap). FT Possible fadD11', fatty-acid-CoA synthetase (EC 6.2.1.-), FT similar to the N-terminus of many fatty-acid CoA FT synthetases e.g. NP_147860.1|NC_000854 FT long-chain-fatty-acid--CoA ligase from Aeropyrum pernix FT (651 aa); P31685|4CL2_SOLTU 4-coumarate--CoA ligase 2 (EC FT 6.2.1.12) from Solanum tuberosum (Potato) (545 aa), FASTA FT scores: opt: 168, E(): 4.4e-06, (30.4% identity in 112 aa FT overlap); etc. Possible frameshift with respect to next ORF FT Rv1550|MTCY48.15c but we can find no sequence error to FT account for this. Probable fadD11, fatty-acid-CoA FT synthetase (EC 6.2.1.-), similar, except in N-terminus, to FT many e.g. SC6A5.39|T35430 probable FT long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) from FT Streptomyces coelicolor (612 aa); NP_301672.1|NC_002677 FT putative long-chain-fatty-acid-CoA ligase from FT Mycobacterium leprae (600 aa); P44446|LCFH_HAEIN putative FT long-chain-fatty-acid-CoA ligase from Haemophilus FT influenzae (607 aa), FASTA scores: opt: 762, E(): 2.3e-38, FT (34.4% identity in 436 aa overlap); etc. Contains PS00455 FT Putative AMP-binding domain signature. BELONGS TO THE FT ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 FT genes. In Mycobacterium bovis, a two single base insertions FT (*-c and *-c) lead to a single product." FT /db_xref="GOA:Q7TZX2" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7TZX2" FT /protein_id="CAD96243.1" FT /translation="MGRHGSRWSRPPCFRVLRLWTYAHRCDLGHTDPLSRRTEMTTTER FT PTTMCEAFQRTAVMDPDAVALRTPGGNQTMTWRDYAAQVRRVAAGLAGLGVRRGDTVSL FT MMANRIEFYPLDVGAQHVGATSFSVYNTLPAEQLTYVFDNAGTKVVICEQQYVDRVRAS FT GVPIEHIVCVDGAPPGTLSLTDLYAAASGDFFDFESTWRAVQPEDIVTLIYTSGTTGNP FT KGVEMTHANLLFEGYAIDEVLGIRFGDRVTSFLPSAHIADRMTGLYLQEMFGTQVTAVA FT DARTIAAALPDVRPTVWGAVPRVWEKLKAGIEFTVARETDEMKRQALAWAMSVAGKRAN FT ALLAGESMSDQLVAEWAKADESVLSKLRERLGFGELRWALSGAAPIPKETLAFFAGIGI FT PIAEIWGMSELSCVATASHPRDGRLGTVGKLLPGLQGKIAEDGEYLVRGPLVMKGYRKE FT PAKTAEAIDSDGWLHTGDVFDIDSDGYLRVVDRKKELIINAAGKNMSPANIENTILAAC FT PMVGVMMAIGDGRTYNTALLVFDADSLGPYAAQRGLDASPAALAADPEVIARIAAGVAE FT GNAKLSRVEQIKRFRILPTLWEPGGDEITLTMKLKRRRIAAKYSAEIEELYASELRPQV FT YEPAAVPSTQPA" FT CDS 125460..127325 FT /transl_table=11 FT /gene="plsB1" FT /locus_tag="Mb1577" FT /product="Possible acyltransferase plsB1" FT /EC_number="2.-.-.-" FT /note="Mb1577, plsB1, len: 621 aa. Equivalent to Rv1551, FT len: 621 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 621 aa overlap). Possible plsB1, FT acyltransferase (EC 2.-.-.-), similar to PLSB_HAEIN|P44857 FT glycerol-3-phosphate acyltransferase from Haemophilus FT influenzae (810 aa), FASTA scores: opt: 434, E(): 6.2e-22, FT (27.6% identity in 395 aa overlap). Also similar to FT Rv2482c|plsB2 Probable glycerol-3-phosphate acyltransferase FT from M.tuberculosis (789 aa)." FT /db_xref="GOA:P65735" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/Swiss-Prot:P65735" FT /protein_id="CAD96244.1" FT /translation="MTAREVGRIGLRKLLQRIGIVAESMTPLATDPVEVTQLLDARWYD FT ERLRALADELGRDPDSVRAEAAGYLREMAASLDERAVQAWRGFSRWLMRAYDVLVDEDQ FT ITQLRKLDRKATLAFAFSHRSYLDGMLLPEAILANRLSPALTFGGANLNFFPMGAWAKR FT TGAIFIRRQTKDIPVYRFVLRAYAAQLVQNHVNLTWSIEGGRTRTGKLRPPVFGILRYI FT TDAVDEIDGPEVYLVPTSIVYDQLHEVEAMTTEAYGAVKRPEDLRFLVRLARQQGERLG FT RAYLDFGEPLPLRKRLQEMRADKSGTGSEIERIALDVEHRINRATPVTPTAVVSLALLG FT ADRSLSISEVLATVRPLASYIAARNWAVAGAADLTNRSTIRWTLHQMVASGVVSVYDAG FT TEAVWGIGEDQHLVAAFYRNTAIHILVDRAVAELALLAAAETTTNGSVSPATVRDEALS FT LRDLLKFEFLFSGRAQFEKDLANEVLLIGSVVDTSKPAAAADVWRLLESADVLLAHLVL FT RPFLDAYHIVADRLAAHEDDSFDEEGFLAECLQVGKQWELQRNIASAESRSMELFKTAL FT RLARHRELVDGADATDIAKRRQQFADEIATATRRVNTIAELARRQ" FT CDS 127696..129447 FT /transl_table=11 FT /gene="frdA" FT /locus_tag="Mb1578" FT /product="PROBABLE FUMARATE REDUCTASE [FLAVOPROTEIN FT SUBUNIT] FRDA (FUMARATE DEHYDROGENASE) (FUMARIC FT HYDROGENASE)" FT /EC_number="1.3.99.1" FT /note="Mb1578, frdA, len: 583 aa. Equivalent to Rv1552, FT len: 583 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 583 aa overlap). Probable frdA, fumarate FT reductase, flavoprotein subunit (EC 1.3.99.1), highly FT similar to others e.g. P00363|FRDA_ECOLI fumarate reductase FT flavoprotein subunit from Escherichia coli strain K12 (601 FT aa), FASTA scores: opt: 2102, E(): 0, (54.7% identity in FT 585 aa overlap); NP_232284.1|NC_002505 fumarate reductase, FT flavoprotein subunit from Vibrio cholerae (602 aa); FT frdA|NP_438995.1|NC_000907 fumarate reductase, flavoprotein FT subunit from Haemophilus influenzae (599 aa); etc. Contains FT PS00504 Fumarate reductase / succinate dehydrogenase FT FAD-binding site. NOTE THAT FUMARATE REDUCTASE FORMS PART FT OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FT FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), FT AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and FT Rv1555|frdD)." FT /db_xref="GOA:P64175" FT /db_xref="HSSP:1KF6" FT /db_xref="InterPro:IPR014006" FT /db_xref="UniProtKB/Swiss-Prot:P64175" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96245.1" FT /translation="MTAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHT FT VSAEGGAAAVTGDDDSLDEHAHDTVSGGDWLCDQDAVEAFVAEAPKELVQLEHWGCPWS FT RKPDGRVAVRPFGGMKKLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTLLVD FT DGRVCGLVAIELATGRIETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAP FT LKDMEFVQYHPTGLPFTGILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSME FT LGPRDRLSQAFVHEHNKGRTVDTPYGPVVYLDLRHLGADLIDAKLPFVRELCRDYQHID FT PVVELVPVRPVVHYMMGGVHTDINGATTLPGLYAAGETACVSINGANRLGSNSLPELLV FT FGARAGRAAADYAARHQKSDRGPSSAVRAQARTEALRLERELSRHGQGGERIADIRADM FT QATLESAAGIYRDGPTLTKAVEEIRVLQERFATAGIDDHSRTFNTELTALLELSGMLDV FT ALAIVESGLRREESRGAHQRTDFPNRDDEHFLAHTLVHRESDGTLRVGYLPVTITRWPP FT GERVYGR" FT CDS 129450..130574 FT /transl_table=11 FT /gene="frdBC" FT /locus_tag="Mb1579" FT /product="PROBABLE FUMARATE REDUCTASE [IRON-SULFUR SUBUNIT] FT FRDB and [MEMBRANE ANCHOR SUBUNIT] FRDC (FUMARATE FT DEHYDROGENASE) (FUMARIC HYDROGENASE)" FT /EC_number="1.3.99.1" FT /note="Mb1579, frdBC, len: 374 aa. Equivalent to Rv1553 FT (frdB) and Rv1554 (frdC), len: 247 aa and len: 126 aa, from FT Mycobacterium tuberculosis strain H37Rv, (100% identity in FT 247 aa overlap and 99.2% identity in 126 aa overlap). FT Probable frdB, fumarate reductase, iron-sulfur subunit (EC FT 1.3.99.1), highly similar to others e.g. P00364|FRDB_ECOLI FT fumarate reductase iron-sulfur protein from Escherichia FT coli strain K12 (243 aa), FASTA scores: opt: 846, E(): 0, FT (50.0% identity in 242 aa overlap); P20921|FRDB_PROVU FT FUMARATE REDUCTASE IRON-SULFUR PROTEIN from Proteus FT vulgaris (245 aa); G64097 fumarate reductase (EC 1.3.99.1) FT iron-sulfur protein from Haemophilus influenzae (276 aa); FT etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur FT binding region signature. And probable frdC, fumarate FT reductase, membrane-anchor subunit (EC 1.3.99.1), highly FT similar to others e.g. P03805|FRDC_ECOLI fumarate reductase FT 15 kDa hydrophobic protein from Escherichia coli strain K12 FT (131 aa), FASTA scores, opt: 268, E(): 3.9e-10, (31.1% FT identity in 122 aa overlap); NP_458780.1|NC_003198 fumarate FT reductase complex subunit C; membrane anchor polypeptide FT from Salmonella enterica subsp. enterica serovar Typhi (131 FT aa); P20923|FRDC_PROVU FUMARATE REDUCTASE 15 KD HYDROPHOBIC FT PROTEIN from Proteus vulgaris (131 aa); etc. NOTE THAT FT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX FT CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN FT IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR FT PROTEINS (Rv1554|frdC and Rv1555|frdD). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 FT genes. In Mycobacterium bovis, a 4 bp insertion (*-gggg) FT leads to a single product." FT /db_xref="GOA:Q7TZX1" FT /db_xref="HSSP:1KF6" FT /db_xref="InterPro:IPR004489" FT /db_xref="UniProtKB/TrEMBL:Q7TZX1" FT /protein_id="CAD96246.1" FT /translation="MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDH FT LDGTLSFRWSCRMGICGSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDLVV FT DISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPVYA FT LDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPA FT GAIQRYKLTAATHALKKLLFPWGGGRMSAYRQPVERYWWARRRSYLRFMLREISCIFVA FT WFVLYLVLVLRAVGAGGNSYQRFLDFSANPVVVVLNVVALSFLLLHAVTWFGSAPRAMV FT IQVRGRRVPARAVLAGHYAAWLVVSVIVAWMVLS" FT CDS 130571..130948 FT /transl_table=11 FT /gene="frdD" FT /locus_tag="Mb1580" FT /product="PROBABLE FUMARATE REDUCTASE [MEMBRANE ANCHOR FT SUBUNIT] FRDD (FUMARATE DEHYDROGENASE) (FUMARIC FT HYDROGENASE)" FT /EC_number="1.3.99.1" FT /note="Mb1580, frdD, len: 125 aa. Equivalent to Rv1555, FT len: 125 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 125 aa overlap). Probable frdD, fumarate FT reductase, membrane-anchor subunit (EC 1.3.99.1), similar FT to others e.g. P03806|FRDD_ECOLI fumarate reductase 13 kDa FT hydrophobic protein from Escherichia coli strain K12 (119 FT aa), FASTA scores: opt: 212, E(): 4.4e-08, (36.8% identity FT in 106 aa overlap); etc. NOTE THAT FUMARATE REDUCTASE FORMS FT PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FT FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), FT AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and FT Rv1555|frdD)." FT /db_xref="GOA:P67644" FT /db_xref="HSSP:1FUM" FT /db_xref="InterPro:IPR003418" FT /db_xref="UniProtKB/Swiss-Prot:P67644" FT /protein_id="CAD96247.1" FT /translation="MTPSTSDARSRRRSAEPFLWLLFSAGGMVTALVAPVLLLLFGLAF FT PLGWLDAPDHGHLLAMVRNPITKLVVLVLVVLALFHAAHRFRFVLDHGLQLGRFDRVIA FT LWCYGMAVLGSATAGWMLLTM" FT CDS 131016..131624 FT /transl_table=11 FT /gene="Mb1581" FT /locus_tag="Mb1581" FT /product="Possible regulatory protein" FT /note="Mb1581, -, len: 202 aa. Equivalent to Rv1556, len: FT 202 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 202 aa overlap). Possible regulatory protein, FT similar to X86780|SHGCPIR2|g987088 orfY, regulator of FT antibiotic transport complexes from Streptomyces FT hygroscopicus (204 aa), FASTA score: opt: 251, E(): FT 1.7e-10, (33.8% identity in 201 aa overlap) and others." FT /db_xref="GOA:P67437" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:P67437" FT /protein_id="CAD96248.1" FT /translation="MVGAVTQIADRPTDPSPWSPRETELLAVTLRLLQEHGYDRLTVDA FT VAASARASKATVYRRWPSKAELVLAAFIEGIRQVAVPPNTGNLRDDLLRLGELICREVG FT QHASTIRAVLVEVSRNPALNDVLQHQFVDHRKALIQYILQQAVDRGEISSAAISDELWD FT LLPGYLIFRSIIPNRPPTQDTVQALVDDVILPSLTRSTG" FT CDS 131763..132209 FT /transl_table=11 FT /gene="mmpS6" FT /locus_tag="Mb1582" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS6" FT /note="Mb1582, mmpS6, len: 148 aa. No equivalent in FT Mycobacterium tuberculosis strain H37Rv. Probable mmpS6, FT conserved membrane protein (see citations below), highly FT similar to other Mycobacterial proteins e.g. FT P54880|MMS4_MYCLE|ML2377|U1740W|MMPS4 Putative membrane FT protein from Mycobacterium leprae (154 aa), FASTA scores: FT opt: 521, E(): 4.7e-29, (53.06% identity in 147 aa FT overlap); FT P95212|MMPS1|MMS1_MYCTU|Rv0403c|MT0415|MTCY04D9.16c FT PROBABLE CONSERVED MEMBRANE PROTEIN from Mycobacterium FT tuberculosis (142 aa), FASTA scores: opt: 518, E(): FT 7.2e-29, (56.75% identity in 141 aa overlap); FT O53736|MMS4_MYCTU|MMPS4|Rv0451c|MT0467|MTV037.15c PROBABLE FT CONSERVED MEMBRANE PROTEIN from Mycobacterium tuberculosis FT (140 aa), FASTA scores: opt: 498, E(): 1.8e-27, (52.85% FT identity in 140 aa overlap); etc. BELONGS TO THE MMPS FT FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a 2153 bp insertion leads to a new protein with no FT equivalent in Mycobacterium tuberculosis strain H37Rv. FT Belongs to the TbD1 region." FT /db_xref="InterPro:IPR008693" FT /db_xref="UniProtKB/TrEMBL:Q7TZX0" FT /protein_id="CAD96249.1" FT /translation="MQGISVTGLVKRGWMVLVAVAVVAVAGFSVYRLHGIFGSHDTTST FT AGGVANDIKPFNPKQVTLEVFGAPGTVATINYLDVDATPRQVLDTTLPWSYTITTTLPA FT VFANVVAQGDSNSIGCRITVNGVVKDERIVNEVRAYTFCLDKSS" FT CDS 132206..135109 FT /transl_table=11 FT /gene="mmpL6" FT /locus_tag="Mb1583" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL6" FT /note="Mb1583, mmpL6, len: 967 aa. Equivalent to 3' end of FT Rv1557, len: 397 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.5% identity in 384 aa overlap). Probable mmpL6, FT conserved transmembrane transport protein (see citations FT below). Member of RND superfamily, with strong similarity FT to other members of large Mycobacterial membrane protein FT family belonging to RND superfamily e.g. FT Q11171|MML2_MYCTU|MMPL2|Rv0507|MT0528|MTCY20G9.34 PROBABLE FT CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from FT Mycobacterium tuberculosis (968 aa), FASTA scores: opt: FT 4142, E(): 0, (64.4% identity in 947 aa overlap); FT O53735|MML4_MYCTU|MMPL4|Rv0450c|MT0466|MTV037.14c PROBABLE FT CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from FT Mycobacterium tuberculosis (967 aa), FASTA scores: opt: FT 4035, E(): 0, (61.5% identity in 948 aa overlap); FT P54881|MML4_MYCLE|MMPL4|ML2378|U1740V Putative membrane FT protein from Mycobacterium leprae (959 aa), FASTA scores: FT opt: 3961, E(): 0, (60.95% identity in 945 aa overlap); FT etc. BELONGS TO THE MMPL FAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT 2153 bp insertion leads to a longer product compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv. Belongs FT to the TbD1 region." FT /db_xref="GOA:Q7TZW9" FT /db_xref="InterPro:IPR000731" FT /db_xref="UniProtKB/TrEMBL:Q7TZW9" FT /protein_id="CAD96250.1" FT /translation="MSNHHRPRPWLPHTIRRLSLPILLFWVGVAAITNAAVPQLEVVGE FT AHNVAQSSPDDPSLQAMKRIGKVFHEFDSDSAAMIVLEGDKPLGNDAHRFYDTLLRNLS FT NDTKHVEHVQDFWGDPLTAAGSQSTDGKAAYVQVYLAGNQGEALSIESVDAVRDIVAHT FT PPPAGVKAYVTGAAPLMADQFQVGSKGTAKVTGITLVVIAVMLLFVYRSVVTMVLVLIT FT VLIELAAARGIVAFLGNAGVIGLSTYSTNLLTLLVIAAGTDYAIFVLGRYHEARYAAQD FT RETAFYTMYRGTAHVVLGSGLTVAGAVYCLSFTRLPYFQSLGIPASIGVMIALAAALSL FT APSVLILGSRFGCFEPKRRMRTRGWRRIGTAIVRWPGPILAVACAIAVVGLLALPGYKT FT SYDARYYMPATAPANIGYMAAERHFPQARLNPELLMIETDHDMRNPADMLILDRIAKAV FT FHLPGIGLVQAMTRPLGTPIDHSSIPFQISMQSVGQIQNLKYQRDRAADLLKQAEELGK FT TIEILQRQYALQQELAAATHEQAESFHQTIATVKELRDRIANFDDFFRPIRSYFYWEKH FT CYDIPSCWALRSVFDTIDGIDQLGEQLASVTVTLDKLAAIQPQLVALLPDEIASQQINR FT ELALANYATMSGIYAQTAALIENAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRGLKLF FT LSADGKAARMIISHEGDPATPEGISHIDAIKQAAHEAVKGTPMAGAGIYLAGTAATFKD FT IQDGATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVLVWQHL FT LGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGIIRAMAGTGGVVTAAG FT LVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDTLVVRAFMTPSIAVLLGRWFWWPQRVR FT PRPASRMLRPYGPRPVVRELLLREGNDDPRTQVATHR" FT CDS 135119..135565 FT /transl_table=11 FT /gene="Mb1584" FT /locus_tag="Mb1584" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1584, -, len: 148 aa. Equivalent to Rv1558, len: FT 148 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 148 aa overlap). Conserved hypothetical FT protein, similar to other Mycobacterial tuberculosis FT proteins e.g. P71854|MTCY03C7.09c|Rv3547 (151 aa), FASTA FT scores opt: 330, E(): 9.1e-17, (39.7% identity in 151 aa FT overlap); also Q11057|Rv1261c (149 aa), and O53328|Rv3178 FT (119 aa). Similar also to AF072709|AF072709_5 Hypothetical FT protein with a new amplifiable element AUD4 from FT Streptomyces lividans (149 aa), FASTA scores: opt: 695, FT E(): 0, (69.1% identity in 149 aa overlap)." FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/Swiss-Prot:P64876" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96251.1" FT /translation="MPLSGEYAPSPLDWSREQADTYMKSGGTEGTQLQGKPVILLTTVG FT AKTGKLRKTPLMRVEHDGQYAIVASLGGAPKNPVWYHNVVKNPRVELQDGTVTGDYDAR FT EVFGDEKAIWWQRAVAVWPDYASYQTKTDRQIPVFVLTPVRAGG" FT CDS 135600..136889 FT /transl_table=11 FT /gene="ilvA" FT /locus_tag="Mb1585" FT /product="Probable threonine dehydratase ilvA" FT /EC_number="4.3.1.19" FT /note="Mb1585, ilvA, len: 429 aa. Equivalent to Rv1559, FT len: 429 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 429 aa overlap). Probable ilvA, threonine FT dehydratase (EC 4.3.1.19), biosynthetic protein, similar to FT several e.g. THD1_CORGL|Q04513 threonine dehydratase FT biosynthetic (436 aa), FASTA scores: opt: 1694, E(): 0, FT (61.9% identity in 415 aa overlap). Contains PS00165 FT Serine/threonine dehydratases pyridoxal-phosphate FT attachment site." FT /db_xref="GOA:P66898" FT /db_xref="HSSP:1TDJ" FT /db_xref="InterPro:IPR001926" FT /db_xref="UniProtKB/Swiss-Prot:P66898" FT /protein_id="CAD96252.1" FT /translation="MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLS FT AITGATVYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFAYACRC FT LGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATLVPP FT FDDLRTIAGQGTIAVEVLGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEP FT AGAAAMMAALAAGEPVTLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVC FT TAMLDLYQNEGIIAEPAGALSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLV FT HLGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAA FT DLDGLLARMRATDIHVEALEPGSPAYRYLL" FT CDS 136927..137145 FT /transl_table=11 FT /gene="Mb1586" FT /locus_tag="Mb1586" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1586, -, len: 72 aa. Equivalent to Rv1560, len: 72 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 72 aa overlap). Conserved hypothetical protein, FT part of a Mycobacterial tuberculosis family of proteins FT e.g. Q10848|Rv2009|MTCY39.08c (80 aa), FASTA score: (54.4% FT identity in 68 aa overlap); Q10799|Rv2871|MTCY274.02 (85 FT aa); O50456|Rv1241|MTV006.13 (86 aa), FT O06243|Rv2132|MTCY270.36C (76 aa); etc." FT /db_xref="InterPro:IPR019239" FT /db_xref="UniProtKB/Swiss-Prot:P64878" FT /protein_id="CAD96253.1" FT /translation="MYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSP FT LSREFLLGLEGVGWEGDLDDLRSDRPD" FT CDS 137151..137555 FT /transl_table=11 FT /gene="Mb1587" FT /locus_tag="Mb1587" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1587, -, len: 134 aa. Equivalent to Rv1561, len: FT 134 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 134 aa overlap). Conserved hypothetical FT protein, similar to others from Mycobacterium tuberculosis FT e.g. Q10847|Rv2010|MTCY39.07c (132 aa), FASTA scores: FT (37.0% identity in 127 aa overlap); and FT O06566|Rv1114|MTCY22G8.03 (124 aa)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/Swiss-Prot:P64880" FT /protein_id="CAD96254.1" FT /translation="MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEI FT LSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAAGIYRAARRAGETVRSINDCLIAAL FT AIRHGARIVHRDADFDVIARITNLQAASFR" FT CDS complement(137572..139314) FT /transl_table=11 FT /gene="treZ" FT /locus_tag="Mb1588c" FT /standard_name="glgZ" FT /product="Maltooligosyltrehalose trehalohydrolase TreZ" FT /note="Mb1588c, treZ, len: 580 aa. Equivalent to Rv1562c, FT len: 580 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 580 aa overlap). treZ (previously called FT glgZ), Maltooligosyltrehalose trehalohydrolase, confirmed FT biochemically (see citation below). Similar to FT Q44316|D63343 TREZ MALTOOLIGOSYL TREHALOSE TREHALOHYDROLASE FT from ARTHROBACTER SP (598 aa), FASTA scores: opt: 2071, FT E(): 0, (52.2% identity in 582 aa overlap); also similar to FT 1,4-alpha-glucan branching enzymes e.g. GLGB_BACST|P30538 FT (639 aa), FASTA scores: opt: 313, E(): 3.8e-13, (27.5% FT identity in 462 aa overlap). Also similar to Mycobacterium FT tuberculosis proteins Rv1326c|glgB, and Rv1563c treY FT (previously glgY)." FT /db_xref="GOA:Q7VEY8" FT /db_xref="HSSP:1EH9" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/TrEMBL:Q7VEY8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96255.1" FT /translation="MPEFRVWAPKPALVRLDVNGAVHAMTRSADGWWHTTVAAPADARY FT GYLLDDDPTVLPDPRSARQPDGVHARSQRWEPPGQFGAARTDTGWPGRSVEGAVIYELH FT IGTFTTAGTFDAAIEKLDYLVDLGIDFVELMPVNSFAGTRGWGYDGVLWYSVHEPYGGP FT DGLVRFIDACHTRRLGVLIDAVFNHLGPSGNYLPRFGPYLSSASNPWGDGINIAGADSD FT EVRHYIIDCALRWMRDFHADGLRLDAVHALVDTTAVHVLEELANATRWLSGQLGRPLSL FT IAETDRNDPRLITRPSHGGYGITAQWNDDIHHAIHTAVSGERQGYYADFGSLATLAYTL FT RNGYFHAGTYSSFRRRRHGRALDTSAIPATRLLAYTCTHDQVGNRALGDRPSQYLTGGQ FT LAIKAALTLGSPYTAMLFMGEEWGASSPFQFFCSHPEPELAHSTVAGRKEEFAEHGWAA FT DDIPDPQDPQTFQRCKLNWAEAGSGEHARLHRFYRDLIALRHNEADLADPWLDHLMVDY FT DEQQRWVVMRRGQLMIACNLGAEPTCVPVSGELVLAWESPIIGDNSTELAAYSLAILRA FT AEPA" FT CDS complement(139307..140041) FT /transl_table=11 FT /gene="treYb" FT /locus_tag="Mb1589c" FT /standard_name="glgY" FT /product="Maltooligosyltrehalose synthase TreYb [SECOND FT PART]" FT /note="Mb1589c, treYb, len: 244 aa. Equivalent to the 3' FT end of Rv1563c, len: 765 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100% identity in 244 aa FT overlap). treY (previously called glgY), maltooligosyl FT trehalose synthase, confirmed biochemically (see citation FT below). Strong similarity to Q44315|63343 TREY FT MALTOOLIGOSYL TREHALOSE SYNTHASE from ARTHROBACTER SP (775 FT aa), fasta scores: opt: 1953, E(): 0; (46.0% identity in FT 789 aa overlap). Some similarity to alpha-amylases and to FT MTCY48.03 (30.2% identity in 215 aa overlap). May catalyse FT conversion of maltodextrins to maltooligosyl trehaloses. FT Also similar to Mycobacterium tuberculosis glgB (Rv1326c), FT treZ (Rv1562c). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1563c/treY FT exists as a single gene. In Mycobacterium bovis, a large FT deletion of 806 bp splits Rv1563c into two parts, treYa and FT treYb." FT /db_xref="GOA:Q7VEY7" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/TrEMBL:Q7VEY7" FT /protein_id="CAD96256.1" FT /translation="MTGQFLWQNVFGVWPVSGEVSAALRGRLHTYAEKAIREAAWHTSW FT HNPNRAFEDDVHGWLDLVLDGPLASELTGLVAHLNSHAESDALAAKLLALTVPGVPDVY FT QGSELWDDSLVDPDNRRPVDYGTRRVALKALQHPKIRVLAAALRLRRTHPESFLGGAYH FT PVFAAGPAADHVVAFRRGDDILVAVTRWTVRLQQTGWDHTVLPLPDGSWTDALTGFTAS FT GHTPAVELFADLPVVLLVRDNA" FT CDS complement(140046..140798) FT /transl_table=11 FT /gene="treYa" FT /locus_tag="Mb1590c" FT /standard_name="glgY" FT /product="Maltooligosyltrehalose synthase TreYa [FIRST FT PART]" FT /note="Mb1590c, treYa, len: 250 aa. Equivalent to the 5' FT end of Rv1563c, len: 765 aa, from Mycobacterium FT tuberculosis strain H37Rv, (97.4% identity in 191 aa FT overlap). treY (previously called glgY), maltooligosyl FT trehalose synthase, confirmed biochemically (see citation FT below). Strong similarity to Q44315|63343 TREY FT MALTOOLIGOSYL TREHALOSE SYNTHASE from ARTHROBACTER SP (775 FT aa), fasta scores: opt: 1953, E(): 0; (46.0% identity in FT 789 aa overlap). Some similarity to alpha-amylases and to FT MTCY48.03 (30.2% identity in 215 aa overlap). May catalyse FT conversion of maltodextrins to maltooligosyl trehaloses. FT Also similar to Mycobacterium tuberculosis glgB (Rv1326c), FT treZ (Rv1562c). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1563c/treY FT exists as a single gene. In Mycobacterium bovis, a large FT deletion of 806 bp splits Rv1563c in two parts, treYa and FT treYb." FT /db_xref="GOA:Q7VEY6" FT /db_xref="HSSP:1IV8" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/TrEMBL:Q7VEY6" FT /protein_id="CAD96257.1" FT /translation="MAFPVISTYRVQMRGRSNGFGFTFADAENLLDYLDDLGVSHLYLS FT PILTAVGGSTHGYDVTDPTTVSPELGGSDGLARLSAAARSRGMGLIVDIVPSHVGVGKP FT EQNAWWWDVLKFGRSSAYAEFFDIDWELGDGRIILPLLGSDSDVANLRVDGDLLRLGDL FT ALPVAPGSGDGTGPAVHDRQHSVWCGRRGVSSPGRHPCSVVATVHDDTVHPRHQTRRGR FT ACPHRRAVPSAVAVGQVHRPRPSHCARP" FT CDS complement(140802..142967) FT /transl_table=11 FT /gene="treX" FT /locus_tag="Mb1591c" FT /standard_name="glgX" FT /product="Maltooligosyltrehalose synthase TreX" FT /note="Mb1591c, treX, len: 721 aa. Equivalent to Rv1564c, FT len: 721 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 721 aa overlap). Probable treX FT (previously called glgX), Maltooligosyltrehalose synthase. FT Strong similarity to D83245|g1890053 treX, glycogen FT debranching enzyme (glgX) from Sulfolobus acidocaldarius FT (713 aa), FASTA score: opt: 2396, E(): 0, (48.4% identity FT in 709 aa overlap); similar to GLGX_HAEIN|P45178 glycogen FT operon protein glgx (659 aa), FASTA scores: opt: 1512, E(): FT 0, (42.3% identity in 645 aa overlap)." FT /db_xref="GOA:P0A4Y5" FT /db_xref="HSSP:1BF2" FT /db_xref="InterPro:IPR013783" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Y5" FT /protein_id="CAD96258.1" FT /translation="MSSNNAGESDGTGPALPTVWPGNAYPLGATYDGAGTNFSLFSEIA FT EKVELCLIDEDGVESRIPLDEVDGYVWHAYLPNITPGQRYGFRVHGPFDPAAGHRCDPS FT KLLLDPYGKSFHGDFTFGQALYSYDVNAVDPDSTPPMVDSLGHTMTSVVINPFFDWAYD FT RSPRTPYHETVIYEAHVKGMTQTHPSIPPELRGTYAGLAHPVIIDHLNELNVTAVELMP FT VHQFLHDSRLLDLGLRNYWGYNTFGFFAPHHQYASTRQAGSAVAEFKTMVRSLHEAGIE FT VILDVVYNHTAEGNHLGPTINFRGIDNTAYYRLMDHDLRFYKDFTGTGNSLNARHPHTL FT QLIMDSLRYWVIEMHVDGFRFDLASTLARELHDVDRLSAFFDLVQQDPVVSQVKLIAEP FT WDVGEGGYQVGNFPGLWTEWNGKYRDTVRDYWRGEPATLGEFASRLTGSSDLYEATGRR FT PSASINFVTAHDGFTLNDLVSYNDKHNEANGENNRDGESYNRSWNCGVEGPTDDPDILA FT LRARQMRNMWATLMVSQGTPMIAHGDEIGRTQYGNNNVYCQDSELSWMDWSLVDKNADL FT LAFARKATTLRKNHKVFRRRRFFEGEPIRSGDEVRDIAWLTPSGREMTHEDWGRGFDRC FT VAVFLNGEAITAPDARGERVVDDSFLLCFNAHDHDVEFVMPHDGYAQQWTGELDTNDPV FT GDIDLTVTATDTFSVPARSLLVLRKTL" FT CDS complement(143006..145195) FT /transl_table=11 FT /gene="Mb1592c" FT /locus_tag="Mb1592c" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1592c, -, len: 729 aa. Equivalent to Rv1565c, len: FT 729 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 729 aa overlap). Conserved hypothetical FT membrane protein, some similarity to O05402 HYPOTHETICAL FT 72.2 KD PROTEIN from Bacillus subtilis (634 aa), FASTA FT results: opt: 384, E(): 4.8e-17, (29.1% identity in 378 aa FT overlap); and to Y392_HAEIN|P43993 hypothetical protein FT hi0392 from H. influenzae (245 aa), FASTA results: opt: FT 265, E(): 5.5e-10, (28.3% identity in 247 aa overlap). FT C-terminal half equivalent to AL049478|MLCL458_19 (274 aa) FT (78.5% identity in 274 aa overlap). Also similar to M. FT tuberculosis hypothetical proteins Rv0111, Rv0228, Rv1254, FT Rv0517. N-terminal half hydrophobic." FT /db_xref="GOA:Q7TZW8" FT /db_xref="InterPro:IPR002656" FT /db_xref="UniProtKB/TrEMBL:Q7TZW8" FT /protein_id="CAD96259.1" FT /translation="MLTLSPPRPPALTPEPALPPVTMGTRTTGFYRHDLDGLRGVAIAL FT VAVFHVWFGRVSGGVDVFLALSGFFFGGKILRAALNPDLSLSPIAEVIRLIRRLLPALV FT VVLAGCALLTIAIQPQTRWEAFANQSLASLGYYQNWELASTVSNYLRAGEAVSPLQHIW FT SMSVQGQFYLAFLLLVAGCAYLLRRLFRGPRAPYLRTMFVVLLSTLTLASFIYAIVAHH FT AYQATAYYNTFARAWELLAGALVGAVVPHVRWPMWLRTAVATAALAAILSCGALIDGVK FT EFPGPWALVPVGATMLMILAGANRQGHPGTRDRLPLPNRLLATAPLVALGAMAYSWYLW FT HWPLLIFWLSYTGHRHANFVEGAAVLLVSGLLAYLTTRLVEDPLRYRAPAGVRSPAAVP FT PIPWRLRLRRPTIVLGSVVALLGVALTATSFTWREHVIVQRAAGKELSGLSSRDYPGAR FT ALIDHVRVPKLRMRPTVLEVRHDLPTSTKDGCISDFVNPAIINCTYGDVDAPRTIALAG FT GSHAEHWLTALDLLGRMHHFKVVTYLKMGCPLSTEEVPLIMGNNAPYPQCHQWVQAAMA FT KLVADHPDYVFTTSTRPWNIKPGDVMPATYVGIWQTFADNNIPVLAMRDTPWLVKDGQP FT FIPADCLAKGGNPQSCGIARSKVLVDRNPTLDFVARFPLLKPLDMSDAICRTDTCRAVE FT GNVLVYRDSHHLTPTYMRTMTSELGRQIAANTDWW" FT CDS complement(145294..145986) FT /transl_table=11 FT /gene="Mb1593c" FT /locus_tag="Mb1593c" FT /product="Possible inv protein" FT /note="Mb1593c, -, len: 230 aa. Equivalent to Rv1566c, len: FT 230 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 230 aa overlap). Possible inv protein, probably FT exported as has QQAPV repeats at C-terminus. Similar to FT Q49634 inv protein from Mycobacterium leprae (246 aa), FT FASTA scores: opt: 957, E(): 0, (70.0% identity in 207 aa FT overlap); also to putative invasins 1,2 (O07390, O07391) FT from M. avium. Slightly similar to C-terminus of FT P60_LISMO|P21171 Listeria invasion-associated protein p60 FT precursor. Also similar to Mycobacterium tuberculosis p60 FT homologues Rv1477, Rv1478, Rv0024, Rv2190c." FT /db_xref="InterPro:IPR000064" FT /db_xref="UniProtKB/TrEMBL:Q7VEY5" FT /protein_id="CAD96260.1" FT /translation="MKRSMKSGSFAIGLAMMLAPMVAAPGLAAADPATRPVDYQQITDV FT VIARGLSQRGVPFSWAGGGISGPTRGTGTGINTVGFDASGLIQYAYAGAGLKLPRSSGQ FT MYKVGQKVLPQQARKGDLIFYGPEGTQSVALYLGKGQMLEVGDVVQVSPVRTNGMTPYL FT VRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPP FT PFGTARSR" FT CDS complement(146226..146510) FT /transl_table=11 FT /gene="Mb1594c" FT /locus_tag="Mb1594c" FT /product="hypothetical membrane protein" FT /note="Mb1594c, -, len: 94 aa. Equivalent to Rv1567c, len: FT 94 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 94 aa overlap). Probable membrane protein." FT /db_xref="UniProtKB/TrEMBL:Q7VEY4" FT /protein_id="CAD96261.1" FT /translation="MVTMTSWPSRLFAFTDNVCPPDACPLVPFGVNYYIYPVMWGGIGA FT AIATAVIGPFVSMLKGWYMSFWPIISIAVITVTSIAGYAIAGFSERYWH" FT CDS 146758..148071 FT /transl_table=11 FT /gene="bioA" FT /locus_tag="Mb1595" FT /product="Probable FT adenosylmethionine-8-amino-7-oxononanoate aminotransferase FT bioA" FT /EC_number="2.6.1.62" FT /note="Mb1595, bioA, len: 437 aa. Equivalent to Rv1568, FT len: 437 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 437 aa overlap). Probable bioA, FT adenosylmethionine-8-amino-7-oxononanoate aminotransferase FT (EC 2.6.1.62). Highly similar to BIOA_MYCLE|P4548 from M. FT leprae (436 aa), FASTA results: opt: 2534, E(): 0, (85.1% FT identity in 436 aa overlap). Also similar to other M. FT tuberculosis proteins e.g. MTCY227.12c (449 aa), FASTA FT score: E(): 3.5e-16, (29.5% identity in 421 aa overlap). FT Contains aminotransferases class-III pyridoxal-phosphate FT attachment site (PS00600). BELONGS TO CLASS-III OF FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES." FT /db_xref="GOA:P0A4X7" FT /db_xref="HSSP:1QJ3" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P0A4X7" FT /protein_id="CAD96262.1" FT /translation="MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAW FT LTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLA FT KLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFL FT AMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPV FT VQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCV FT GKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQD FT WRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWL FT RPFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP" FT CDS 148068..149228 FT /transl_table=11 FT /gene="bioF1" FT /locus_tag="Mb1596" FT /product="PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF1 FT (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) FT (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP FT SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE)" FT /EC_number="2.3.1.47" FT /note="Mb1596, bioF1, len: 386 aa. Equivalent to Rv1569, FT len: 386 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 386 aa overlap). Probable bioF1, FT 8-amino-7-oxononanoate synthase (EC 2.3.1.47), highly FT similar to BIOF_MYCLE|P45487 from Mycobacterium leprae (385 FT aa), FASTA results: opt: 1971, E(): 0, (80.1% identity in FT 381 aa overlap). Also similar to BIOF2|Rv0032|MTCY10H4.32 FT POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE from Mycobacterium FT tuberculosis (771 aa), FASTA score: E(): 5.5e-29, (37.4% FT identity in 393 aa overlap). Contains aminotransferases FT class-II pyridoxal-phosphate attachment site (PS00599). FT BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES." FT /db_xref="GOA:P0A4X5" FT /db_xref="HSSP:1BS0" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P0A4X5" FT /protein_id="CAD96263.1" FT /translation="MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDL FT ASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGL FT LFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAAL FT RSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYE FT LGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARA FT ALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGV FT KVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR" FT CDS 149225..149905 FT /transl_table=11 FT /gene="bioD" FT /locus_tag="Mb1597" FT /product="Probable dethiobiotin synthetase bioD" FT /EC_number="6.3.3.3" FT /note="Mb1597, bioD, len: 226 aa. Equivalent to Rv1570, FT len: 226 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 226 aa overlap). Probable bioD, FT dethiobiotin synthetase (EC 6.3.3.3). Similar to many e.g. FT BIOD_MYCLE|P45486 from Mycobacterium leprae (223 aa), FASTA FT results: opt: 1059, E(): 0, (74.8% identity in 222 aa FT overlap). BELONGS TO THE DETHIOBIOTIN SYNTHETASE FAMILY." FT /db_xref="GOA:O52587" FT /db_xref="HSSP:1DTS" FT /db_xref="InterPro:IPR004472" FT /db_xref="UniProtKB/Swiss-Prot:O52587" FT /protein_id="CAD96264.1" FT /translation="MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTAR FT GDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRL FT TLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSC FT AGLVIGSWPDPPGLVAASNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVA FT GLVG" FT CDS 149905..150414 FT /transl_table=11 FT /gene="Mb1598" FT /locus_tag="Mb1598" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1598, -, len: 169 aa. Equivalent to Rv1571, len: FT 169 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 169 aa overlap). Conserved hypothetical FT protein, similar at N-terminal region to FT Q49625|LEPB1170_C3_227 hypothetical protein from FT Mycobacterium leprae (104 aa), FASTA results: opt: 473, FT E(): 3.9e-24, (74.5% identity in 102 aa overlap). Identical FT to O06619|AF041819|AF041819_6 Mycobacterium bovis BCG (169 FT aa)." FT /db_xref="GOA:Q7TZW7" FT /db_xref="UniProtKB/TrEMBL:Q7TZW7" FT /protein_id="CAD96265.1" FT /translation="MVHSIELVFDSDTEAAIRRIWAGLAAAGIPSQAPASRPHVSLAVA FT ERIAPEVDEPLGAVARRLPLDCVIGAPVLFGRANVVFTRLVVPTSELLALHAEVHRLCG FT PHLAPAPMANSLPGQWTAHVTLARRVGGHQLGRALRIAGRPSRIDGRFAGLRRWDGNTR FT AEYLLG" FT CDS complement(150560..150664) FT /transl_table=11 FT /gene="Mb1598A" FT /locus_tag="Mb1598A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1598A, -, len: 34 aa. Equivalent to Rv1572c FT (MTCY336.31B), len: 34 aa, from Mycobacterium tuberculosis FT strain H37Rv (100.0% identity in 34 aa overlap). Partial FT ORF, part of REP13E12 repeat element; 3' end of Rv1613c FT (Rv1587c) (MTCY336.17) after phage-like element (see FT citation below). Similar to C-terminal ends of other FT REP13E12 repeat elements e.g. Rv1148, Rv1945, Rv3467, etc. FT Length extended since first submission (+7 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7TZW6" FT /protein_id="CAD96266.1" FT /translation="MECSSAVHGQPRTNTFHHHEKLLRHNDEDNHDDP" FT CDS 150680..151090 FT /transl_table=11 FT /gene="Mb1599" FT /locus_tag="Mb1599" FT /product="Probable phiRV1 phage protein" FT /note="Mb1599, -, len: 136 aa. Equivalent to Rv1573, len: FT 136 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 136 aa overlap). Probable phiRv1 phage protein FT (see citation below)." FT /db_xref="UniProtKB/TrEMBL:Q7VEY3" FT /protein_id="CAD96267.1" FT /translation="MTTTPARFNHLVTVTDLETGDRAVCDRDQVAETIRAWFPDAPLEV FT REALVRLQAALNRHEHTGELEAFLRISVEHADAAGGDECGPAILAGRSGPEQAAINRQL FT GLAGDDEPDGDDTPPWSRMIGLGGGSPAEDER" FT CDS 151296..151607 FT /transl_table=11 FT /gene="Mb1600" FT /locus_tag="Mb1600" FT /product="Probable phiRV1 phage related protein" FT /note="Mb1600, -, len: 103 aa. Equivalent to Rv1574, len: FT 103 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 103 aa overlap). Probable phiRV1 phage related FT protein (see citation below); some similarity to FT Rv1575|MTCY441.17, E() 1.5e-06; and Rv2647|MTCY336.29c FT phiRV2 phage protein, E(): 3.5e-05. Belongs to phage phiRv1 FT proteins. Helix turn helix motif present at aa 14-35 (+3.61 FT SD)." FT /db_xref="UniProtKB/TrEMBL:Q7VEY2" FT /protein_id="CAD96268.1" FT /translation="MGYKPESERHSTKTDTAIGAALGISAGTYRRLKRIDNATHSDDKE FT IRRFAEKQMAPLVAGSPSWNARKPRSANARVVASVHRSPMPALVPWNQSRLSATLTRR" FT CDS 151712..152065 FT /transl_table=11 FT /gene="Mb1601" FT /locus_tag="Mb1601" FT /product="Probable phiRV1 phage protein" FT /note="Mb1601, -, len: 117 aa. Similar to Rv1575 and FT Rv1575A, len: 117 aa and 65 aa, from Mycobacterium FT tuberculosis strain H37Rv, (66.9% identity in 124 aa FT overlap). Probable phiRV1 phage protein (see citation FT below). Similarity in N-terminal part to Rv1574|MTCY336.30c FT (103 aa), FASTA score: E(): 0.00022, (44.0% identity in 50 FT aa overlap); and Rv2647 phiRV2 phage protein. Similarity FT suggests should continue as Rv1575A. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1575 and Rv1575A exist as 2 FT genes with an overlap region between them. In Mycobacterium FT bovis, a single base deletion (c-*) and a single base FT insertion (*-g) lead to a single product." FT /db_xref="UniProtKB/TrEMBL:Q7VEY1" FT /protein_id="CAD96269.1" FT /translation="MAPLAAGSPSWNGRKPSSGNRKAATMAARLDILAWGPWAQARIGA FT SFDENRHCYRRSPRHLRRHLPAAQTNRQRNPQRVGGVGGPAPLSRGRPRLALSYLRGSL FT HLQNSKRVAHQHI" FT CDS complement(152009..153430) FT /transl_table=11 FT /gene="Mb1602c" FT /locus_tag="Mb1602c" FT /product="Probable phiRV1 phage protein" FT /note="Mb1602c, -, len: 473 aa. Equivalent to Rv1576c, len: FT 473 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 473 aa overlap). Probable phiRV1 phage FT protein (capsid subunit) (see citation below). Highly FT similar to hypothetical Mycobacterium tuberculosis protein FT Rv2650c|MTCY441.19 phiRV2 phage related protein, FASTA FT scores: opt: 2782, E(): 0, (89.1% identity in 468 aa FT overlap)." FT /db_xref="InterPro:IPR006444" FT /db_xref="UniProtKB/TrEMBL:Q7VEY0" FT /protein_id="CAD96270.1" FT /translation="MTEFDDIKNLSLPETRDAAKQLLDSVAGDLTGEAAQRFQALTRHA FT EELRAEQRRRGREAEEELRRYRAGELRVVPGAPTGGDDGDAPPGNSLRDTAFRTLDSCV FT RDGLMSSRAAETAETLCRTGPPQSTSWAQRWLAATGSRDYLGAFVKRVSNPVAGHTVWT FT DREAAAWREAAAVAAEQRAMGLVDTQGGFLIPAALDPAILLSGDGSTNPIRQVARVVQT FT TSEIWRGVTSEGAEARWYSEAQEVSDDSPALAQPAVPNYRGSCWIPFSIELEGDAASFV FT GEIGKILADSVEQLQTAAFVNGSGNGEPTGFVSALTGTSDQVVVGAGSEAIVAADVYAL FT QSALPPRFQASAAFAANLSTINTLRQAETSNGALKFPSLHDSPPMLAGKSVLEVSHMDT FT VDSAVTATNHPLVLGDWKQFLIVDRVGSMVELVPHLFGPNRRPTGQRGFFAWFRVGSDV FT LVRNAFRVLKVETTA" FT CDS complement(153438..153950) FT /transl_table=11 FT /gene="Mb1603c" FT /locus_tag="Mb1603c" FT /product="Probable phiRv1 phage protein" FT /note="Mb1603c, -, len: 170 aa. Equivalent to Rv1577c, len: FT 170 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 170 aa overlap). Probable phiRv1 phage protein FT (prohead protease) (see citation below). Highly similar to FT hypothetical protein Rv2651c|MTCY441.20c phiRV2 prohead FT protease, FASTA scores: E(): 0, (89.3% identity in 169 aa FT overlap). Some similarity to VP4_BPHK7|P49860 putative FT bacteriophage HK97 prohead protease (gp4) (225 aa), FASTA FT results: opt: 176, E(): 1.3e-05, (27.3% identity in 165 aa FT overlap)." FT /db_xref="InterPro:IPR006433" FT /db_xref="UniProtKB/TrEMBL:Q7VEX9" FT /protein_id="CAD96271.1" FT /translation="MAELRSGEGRTVHGTIVPYNEATTVRDFDGEFQEMFAPGAFRRSI FT AERGHKLKLLVSHDARTRYPVGRAVELREEPHGLFGAFEIADTPDGDEALANVKAGVVD FT SFSVGFRPIRDRREGDVLVRVEAALLEVSLTGVPAYSGAQIAGVRAESLTVVSRSTAEA FT WLSLLDW" FT CDS complement(154124..154594) FT /transl_table=11 FT /gene="Mb1604c" FT /locus_tag="Mb1604c" FT /product="Probable phiRv1 phage protein" FT /note="Mb1604c, -, len: 156 aa. Equivalent to Rv1578c, len: FT 156 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 156 aa overlap). Probable phiRv1 phage protein FT (terminase) (see citation below), highly similar to FT Rv2652c|MTCY441.21c phiRV2 phage protein from M. FT tuberculosis, FASTA scores: E(): 4.8e-22, (48.1% identity FT in 156 aa overlap). Also similar to X65555|ARP3COS_1 FT hypothetical protein (cos site) - actinophage RP3 (210 aa), FT FASTA scores: opt: 373, E(): 6.5e-17, (50.0% identity in FT 114 aa overlap). Contains MIP family signature (PS00221)." FT /db_xref="InterPro:IPR006448" FT /db_xref="UniProtKB/TrEMBL:Q7VEX8" FT /protein_id="CAD96272.1" FT /translation="MPRPPKPARLKLVEGRSPGRDSGGRKVPESPKFIRQAPDAPDWLD FT AEALAEWRRVAPTLERLDLLKPEDRALLSAYCETWSVYVAAVQRVRAEGLTITSPKSGV FT VHRNPAVTVAETARMHLLRLASEFGLTPAAEQRLAVAPGDDGDGLNPFAPDR" FT CDS complement(154675..154989) FT /transl_table=11 FT /gene="Mb1605c" FT /locus_tag="Mb1605c" FT /product="Probable phiRv1 phage protein" FT /note="Mb1605c, -, len: 104 aa. Equivalent to Rv1579c, len: FT 104 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 104 aa overlap). Probable phiRv1 phage protein FT (see citation below)." FT /db_xref="UniProtKB/TrEMBL:Q7VEX7" FT /protein_id="CAD96273.1" FT /translation="MTPINRPLTNDERQLMHELAVQVVCSQTGCSPDAAVEALESFAKD FT GTLILRGDTENAYLEAGGNVLVHADRDWLAFHASYPGNDPLRDARPIEQDDDQGAGSPS FT " FT CDS complement(154986..155258) FT /transl_table=11 FT /gene="Mb1606c" FT /locus_tag="Mb1606c" FT /product="Probable phiRv1 phage protein" FT /note="Mb1606c, -, len: 90 aa. Equivalent to Rv1580c, len: FT 90 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 90 aa overlap). Probable phiRv1 phage protein FT (see citation below)." FT /db_xref="UniProtKB/TrEMBL:Q7VEX6" FT /protein_id="CAD96274.1" FT /translation="MAETPDHAELRRRIADMAFNADVGMATCKRCGDAVPYIILPNLQT FT GEPVMGVADNKWKRANCPVDVGKPCPFLIAEGVADSTDDTIEVDQ" FT CDS complement(155272..155667) FT /transl_table=11 FT /gene="Mb1607c" FT /locus_tag="Mb1607c" FT /product="Probable phiRv1 phage protein" FT /note="Mb1607c, -, len: 131 aa. Equivalent to Rv1581c, len: FT 131 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 131 aa overlap). Probable phiRv1 phage protein FT (see citation below)." FT /db_xref="UniProtKB/TrEMBL:Q7VEX5" FT /protein_id="CAD96275.1" FT /translation="MTAVAITPASGGRHSVRFAYDSAIVSLIKSTIPAYARSWSAHTRC FT WFIDADWTPLLAAELRYHGHTVTGPADPAQQQCTDWAKALFRAVGPQRTPAVYRALSKV FT LHPDAPTGCPILQQQLNAARTALTNPA" FT CDS complement(155863..157278) FT /transl_table=11 FT /gene="Mb1608c" FT /locus_tag="Mb1608c" FT /product="Probable phiRv1 phage protein" FT /note="Mb1608c, -, len: 471 aa. Equivalent to Rv1582c, len: FT 471 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 471 aa overlap). Probable phiRv1 phage FT protein (see citation below). N-terminus is similar to FT C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519 aa), FT FASTA scores: opt: 331, E(): 6.5e-15, (28.5% identity in FT 235 aa overlap); and C-terminus to whole of Q38031 ORF10 of FT Bacteriophage phi-C31 (202 aa), FASTA scores: opt: 353, FT E(): 1e-16, (31.1% identity in 190 aa overlap). Also FT similar to part of AB016282|AB016282_42 Bacteriophage FT phi-105 (806 aa), FASTA scores: opt: 790, E(): 0, (32.7% FT identity in 459 aa overlap). Similarity to other phage FT proteins described as putative DNA-polymerase or FT DNA-primase. Also slightly similar to MTCY441.24c, FASTA FT scores: E(): 0.0055, (36.0% identity in 75 aa overlap)." FT /db_xref="InterPro:IPR014015" FT /db_xref="UniProtKB/TrEMBL:Q7VEX4" FT /protein_id="CAD96276.1" FT /translation="MADIPYGTDYPDAPWIDRDGHVLIDDGGKPTQVHRGQARIAYRLA FT ERYQDKLLHVAGIGWHSWDGRRWAADDRGEAKRAVLAELRQALSDSLNDKELRADVRKC FT ESASGVAGVLDLAAALVPFAATLADLDSDPHLLNVANGTLDLHTLKLRPHAPADRITKI FT CRGAYQSDTESPLWQAFLTRVLPDEGVRGFVQRLAGVGLLGTVREHVLAILIGVGANGK FT SVFDKAIRYALGDYACTAEPDLFMHRENAHPTGEMDLRGVRWVAVSESEKDRRLAESTI FT KRLTGGDTIRARKMRQDFVEFTPSHTPLLITNHLPRVPGDDTAIWRRIRVVPFEVVIPA FT DEQDRELDARLQLEADSILSWAVAGWSDYQRIGLSQPDAVLAATSNYREDSDTIKRFID FT DECVTSSPVLKATTTHLFEAWQRWRVQEGVPEISRKAFGQSLDTHGYPVTDKARDGRWR FT AGIAVRGADDFDD" FT CDS complement(157278..157676) FT /transl_table=11 FT /gene="Mb1609c" FT /locus_tag="Mb1609c" FT /product="Probable phiRv1 phage protein" FT /note="Mb1609c, -, len: 132 aa. Equivalent to Rv1583c, len: FT 132 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 132 aa overlap). Probable phiRv1 phage FT protein (see citation below), highly similar to FT Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa), FASTA FT score: E(): 1.3e-33, (81.7% identity in 131 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7VEX3" FT /protein_id="CAD96277.1" FT /translation="MTAGAGGSPPTRRCSATEDRAPATVATPSSADPTASRAVSWWSVH FT EHVAPVLDAAGSWPMAGTPAWRQLDDADPRKWAAICDAARHWALRVETCQEAMAQASRD FT VSAAADWPGIAREIVRRRGVYIPRAGVA" FT CDS complement(157673..157894) FT /transl_table=11 FT /gene="Mb1610c" FT /locus_tag="Mb1610c" FT /product="Possible phiRv1 phage protein" FT /note="Mb1610c, -, len: 73 aa. Equivalent to Rv1584c, len: FT 73 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 73 aa overlap). Possible phiRv1 phage protein FT (putative excisionase) (see citation below)." FT /db_xref="UniProtKB/TrEMBL:Q7VEX2" FT /protein_id="CAD96278.1" FT /translation="MSTIYHHRGRVAALSRSRASDDPEFIAAKTDLVAANIADYLIRTL FT AAAPPLTDEQRTRLAELLRPVRRSGGAR" FT CDS complement(157950..158465) FT /transl_table=11 FT /gene="Mb1611c" FT /locus_tag="Mb1611c" FT /product="Possible phage phiRv1 protein" FT /note="Mb1611c, -, len: 171 aa. Equivalent to Rv1585c, len: FT 171 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 171 aa overlap). Possible phage phiRv1 protein FT (see citation below)." FT /db_xref="UniProtKB/TrEMBL:Q7VEX1" FT /protein_id="CAD96279.1" FT /translation="MSRHHNIVIVCDHGRKGDGRIEHERCDLVAPIIWVDETQGWLPQA FT PAVATLLDDDNQPRAVIGLPPNESRLRPEMRRDGWVRLHWEFACLRYGAAGVRTCEQRP FT VRVRNGDLQTLCENVPRLLTGLAGNPDYAPGFAVQSDAVVVAMWLWRTLCESDTPNKLR FT ATPTRGSC" FT CDS complement(158462..159871) FT /transl_table=11 FT /gene="Mb1612c" FT /locus_tag="Mb1612c" FT /product="Probable phiRv1 integrase" FT /note="Mb1612c, -, len: 469 aa. Equivalent to Rv1586c, len: FT 469 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 469 aa overlap). Probable phiRv1 integrase, FT possibly member of the serine family of recombinases (see FT citation below), similar to several bacteriophage FT integrases e.g. Q37839 ORF469 PROTEIN from Bacteriophage R4 FT (469 aa), FASTA scores: opt: 623, E(): 1.6e-29, (31.1% FT identity in 482 aa overlap); and Bacteriophage TP901-1." FT /db_xref="GOA:Q7VEX0" FT /db_xref="InterPro:IPR006119" FT /db_xref="UniProtKB/TrEMBL:Q7VEX0" FT /protein_id="CAD96280.1" FT /translation="MRYTTPVRAAVYLRISEDRSGEQLGVARQREDCLKLCGQRKWVPV FT EYLDNDVSASTGKRRPAYEQMLADITAGKIAAVVAWDLDRLHRRPIELEAFMSLADEKR FT LALATVAGDVDLATPQGRLVARLKGSVAAHETEHKKARQRRAARQKAERGHPNWSKAFG FT YLPGPNGPEPDPRTAPLVKQAYADILAGASLGDVCRQWNDAGAFTITGRPWTTTTLSKF FT LRKPRNAGLRAYKGARYGPVDRDAIVGKAQWSPLVDEATFWAAQAVLDAPGRAPGRKSV FT RRHLLTGLAGCGKCGNHLAGSYRTDGQVVYVCKACHGVAILADNIEPILYHIVAERLAM FT PDAVDLLRREIHDAAEAETIRLELETLYGELDRLAVERAEGLLTARQVKISTDIVNAKI FT TKLQARQQDQERLRVFDGIPLGTPQVAGMIAELSPDRFRAVLDVLAEVVVQPVGKSGRI FT FNPERVQVNWR" FT CDS complement(159528..160529) FT /transl_table=11 FT /gene="Mb1613c" FT /locus_tag="Mb1613c" FT /product="Partial REP13E12 repeat protein" FT /note="Mb1613c, -, len: 333 aa. Equivalent to Rv1587c, len: FT 217 aa, from Mycobacterium tuberculosis strain H37Rv, FT (97.2% identity in 217 aa overlap). Partial REP13E12 repeat FT protein (see citation below), nearly identical (but has FT been interrupted by phiRv1 prophage) to Q50655|MTCY251.13c FT HYPOTHETICAL 34.6 KD PROTEIN from M. tuberculosis (317 aa), FT FASTA results: opt: 2020, E(): 0, (98.0% identity in 302 aa FT overlap); Rv0094c|MTCY251.13c (317 aa), FASTA results: E(): FT 0, (100.0% identity in 217 aa overlap). Codon usage FT suggests that translation may involve frameshifting of FT Rv1588c mRNA in poly_C stretch into reading frame of FT Rv1587c. 3' end found in Rv1572c. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587 FT possibly exists as a pseudogene that has been disrupted FT when the phage entered." FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:Q7VEL3" FT /protein_id="CAD96281.1" FT /translation="MLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGLL FT AGLRALIASGELGQHNGLPVSIVVTTTLTDLQTGAGKGFTGGGTLLPMADVIRMTSHAH FT HYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFANDRGCTKPGCDAPAYHSQAH FT HVTGWTSTGRTDITDLTLACDPDNRLAEKGWTTRKNTHGHTEWLPPPHLDHGQPWTCEI FT HYTCACCCLPPNLRRPLRRTARRGPPTRGLPKAVRAAKMGARRVPRQRRQRINRQAPPR FT LRADVGRHHRRQDRRRGGLGPGPAPSPSHRAGSLHVISRREAAGPGHRRRRR" FT repeat_region complement(159873..161235) FT /locus_tag="REP-5" FT /rpt_family="REP" FT /note="REP-5, len: 1363 nt. Equivalent to REP, len: 1298 FT nt, from Mycobacterium tuberculosis strain H37Rv, (96.6% FT identity in 1363 nt overlap). REP336, member of REP13E12 FT family." FT CDS complement(160534..161202) FT /transl_table=11 FT /gene="Mb1614c" FT /locus_tag="Mb1614c" FT /product="Partial REP13E12 repeat protein" FT /note="Mb1614c, -, len: 222 aa. Equivalent to Rv1588c, len: FT 222 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.2% identity in 222 aa overlap). Partial REP13E12 repeat FT protein (see citation below), nearly identical to ORF's in FT other Rep13E12 repeats, including FT Rv0095c|MTCY251.14c|Y05E_MYCTU|Q10891 hypothetical 15.4 kd FT protein cy251.14 from Mycobacterium tuberculosis (136 aa), FT FASTA results: opt: 613, E(): 9.9e-29, (86.5% identity in FT 111 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P0A5F2" FT /protein_id="CAD96282.1" FT /translation="MLANSREELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLEC FT LVRRLPAVGHTLINQLDTQASEEELGGTLCCALANRLRITKPDAALRIADAADLGPRRA FT LTGEPLAPQLTATATAQRQGLIGEAHIKVIRALFRPPARRGGCVHPPGRRSRPGRQSRS FT ISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL FT " FT CDS 161650..162699 FT /transl_table=11 FT /gene="bioB" FT /locus_tag="Mb1615" FT /product="biotin synthetase bioB" FT /EC_number="2.8.1.-" FT /note="Mb1615, bioB, len: 349 aa. Equivalent to Rv1589, FT len: 349 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 349 aa overlap). bioB, biotin synthetase FT (EC 2.8.1.-) O06601. Highly similar to BIOB_MYCLE|P46715 FT BioB from Mycobacterium leprae (345 aa), FASTA results: FT opt: 1982, E(): 0, (86.5% identity in 349 aa overlap)." FT /db_xref="GOA:P0A507" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/Swiss-Prot:P0A507" FT /protein_id="CAD96283.1" FT /translation="MTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLAV FT LQLPDDRLEELLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSGLFASPVRS FT AWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLMAQVAAGIEAIRNEVEINIACSL FT GMLTAEQVDQLAARGVHRYNHNLETARSFFANVVTTHTWEERWQTLSMVRDAGMEVCCG FT GILGMGETLQQRAEFAAELAELGPDEVPLNFLNPRPGTPFADLEVMPVGDALKAVAAFR FT LALPRTMLRFAGGREITLGDLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLDELQM FT PLKALNASL" FT CDS 162700..162939 FT /transl_table=11 FT /gene="Mb1616" FT /locus_tag="Mb1616" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1616, -, len: 79 aa. Equivalent to Rv1590, len: 79 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 79 aa overlap). Conserved hypothetical protein, FT similar to Q49616|LEPB1170_C1_162|YF90_MYCLE from FT Mycobacterium leprae (80 aa), FASTA scores: opt: 368, E(): FT 1.7e-21, Smith-Waterman score: 368, (67.1% identity in 73 FT aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64882" FT /protein_id="CAD96284.1" FT /translation="MVEIVAGKQRAPVAAGVYNVYTGELADTATPTAARMGLEPPRFCA FT QCGRRMVVQVRPDGWWARCSRHGQVDSADLATQR" FT CDS 162936..163601 FT /transl_table=11 FT /gene="Mb1617" FT /locus_tag="Mb1617" FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT /note="Mb1617, -, len: 221 aa. Equivalent to Rv1591, len: FT 221 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 221 aa overlap). Probable transmembrane FT protein, similar to Q49626|LEPB1170_C3_229|YF91_MYCLE FT Hypothetical Mycobacterium leprae protein (198 aa), FASTA FT results: opt: 802, E(): 0, (63.8% identity in 188 aa FT overlap)." FT /db_xref="GOA:P0A5F4" FT /db_xref="UniProtKB/Swiss-Prot:P0A5F4" FT /protein_id="CAD96285.1" FT /translation="MTEPPGFGGPSEPSGAPRTSRTRAVLFVMLGLSATGVLVGGLWAW FT IAPPIHAVVAITRAGERVHEYLGSESQNFFIAPFMLLGLLSVLAVVASALMWQWREHRG FT PQMVAGLSIGLTTAAAIAAGVGALVVRLRYGALDFDTVPLSRGDHALTYVTQAPPVFFA FT RRPLQIALTLMWPAGIASLVYALLAAGTARDDLGGYPAVDPSSNARTEALETPQAPVS" FT CDS complement(163766..165106) FT /transl_table=11 FT /gene="Mb1618c" FT /locus_tag="Mb1618c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1618c, -, len: 446 aa. Equivalent to Rv1592c, len: FT 446 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 446 aa overlap). Conserved hypothetical FT protein, some similarity to Q49629|B1170_F1_46 from FT Mycobacterium leprae (132 aa), FASTA results: opt: 332, FT E(): 4.5e-14, (56.3% identity in 87 aa overlap). Nearly FT identical to truncated Mycobacterium bovis BCG protein (148 FT aa) AF041819|AF041819_11." FT /db_xref="GOA:Q7TZW5" FT /db_xref="InterPro:IPR005152" FT /db_xref="UniProtKB/TrEMBL:Q7TZW5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96286.1" FT /translation="MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDDPFYFPPAGY FT QHAVPGTVLRSRDVELAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIVPAELAPGQ FT TCPLLSYQCAIDAMSSRCFPSYALRRRAKALGSLTQMELLMISAALAEGWAVSVPDHEG FT PKGLWGSPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASAWAAEACGEYA FT PDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAALQHSYPGLARVIKEHANDEG FT RQLLEQLTEMTTVDAVIRMAGRDMGDFLDEPLEDILSTPEVSHVFGDTKLGSAVPTPPV FT LIVQAVHDYLIDVSDIDALADSYTAGGANVTYHRDLFSEHVSLHPLSAPMTLRWLTDRF FT AGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL" FT CDS complement(165363..166073) FT /transl_table=11 FT /gene="Mb1619c" FT /locus_tag="Mb1619c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1619c, -, len: 236 aa. Equivalent to Rv1593c, len: FT 236 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 236 aa overlap). Conserved hypothetical FT protein, highly similar to Q49628|B1170_F1_44 from FT Mycobacterium leprae (286 aa), FASTA scores: opt: 1304, E FT (): 0, (85.4% identity in 233 aa overlap); similar to FT several putative DNA hydrolases e.g. Q9S233|SCI51.07C from FT Streptomyces coelicolor (239 aa), FASTA scores: opt: 415, FT E(): 4.6e-20, (34.8% identity in 221 aa overlap); also FT similar to P74291|SLR1690 hypothetical protein from FT synechocystis (261 aa), FASTA scores: opt: 228, E(): FT 1.4e-17, (31.5% identity in 213 aa overlap). TBparse score FT is 0.922" FT /db_xref="GOA:Q7TZW4" FT /db_xref="InterPro:IPR000086" FT /db_xref="UniProtKB/TrEMBL:Q7TZW4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96287.1" FT /translation="MAHGSTAHEVLAVVFQVRGVGMSRGAAKPQLNVLLWQRAKEPQRG FT AWSLPGGRLRNDEDMTSSVRRQLAEKVDLRELAHLEQLAVFSDPHRLPGIRMIASTYLG FT VVPSPATPELPADTRWHPVSSLPPMAFDHGPMVTHARTRLIAKMSYTNIGFALAPKEFA FT LSTLRDIYGAALGYQVDATNLQRVLARRRVITQTGTIAQSGRSGGRPAALYRFTDSQLR FT VTDEFAALRPPGQL" FT CDS 166122..167171 FT /transl_table=11 FT /gene="nadA" FT /locus_tag="Mb1620" FT /product="Probable quinolinate synthetase nadA" FT /note="Mb1620, nadA, len: 349 aa. Equivalent to Rv1594, FT len: 349 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 349 aa overlap). Probable nadA, FT quinolinate synthetase. Similar to many e.g. Q49622 NADA FT from Mycobacterium leprae (368 aa), FASTA results: opt: FT 1994, E(): 0, (84.4% identity in 352 aa overlap)." FT /db_xref="GOA:P65498" FT /db_xref="InterPro:IPR003473" FT /db_xref="UniProtKB/Swiss-Prot:P65498" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96288.1" FT /translation="MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLR FT GATVLAHNYQLPAIQDVADHVGDSLALSRVAAEAPEDTIVFCGVHFMAETAKILSPHKT FT VLIPDQRAGCSLADSITPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNAVDV FT VASIDPDREVLFCPDQFLGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDA FT ELFVHPECGCATSALYLAGEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQ FT LRRAAPEVDFRAVNDRASCKYMKMITPAALLRCLVEGADEVHVDPGIAASGRRSVQRMI FT EIGHPGGGE" FT CDS 167171..168754 FT /transl_table=11 FT /gene="nadB" FT /locus_tag="Mb1621" FT /product="Probable L-aspartate oxidase nadB" FT /EC_number="1.4.3.16" FT /note="Mb1621, nadB, len: 527 aa. Equivalent to Rv1595, FT len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 527 aa overlap). Probable nadB, FT L-aspartate oxidase (EC 1.4.3.16). Similar to many e.g. FT Q49617 L-ASPARTATE OXIDASE (QUINOLINATE SYNTHETASE) from FT Mycobacterium leprae (424 aa), FASTA results: opt: 2152, FT E(): 0, (82.0% identity in 400 aa overlap). Also shows some FT similarity to Rv1552 frdA from Mycobacterium tuberculosis FT (583 aa), FASTA results: E(): 1e-10, (35.3% identity in 566 FT aa overlap). HETERODIMER. THE QUINOLINATE SYNTHETASE FT COMPLEX CONSISTS OF THE TWO ENZYMES QUINOLINATE SYNTHETASE FT A AND B. TBparse score is 0.896." FT /db_xref="GOA:P65500" FT /db_xref="HSSP:1CHU" FT /db_xref="InterPro:IPR005288" FT /db_xref="UniProtKB/Swiss-Prot:P65500" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96289.1" FT /translation="MAGPAWRDAADVVVIGTGVAGLAAALAADRAGRSVVVLSKAAQTH FT VTATHYAQGGIAVVLPDNDDSVDAHVADTLAAGAGLCDPDAVYSIVADGYRAVTDLVGA FT GARLDESVPGRWALTREGGHSRRRIVHAGGDATGAEVQRALQDAAGMLDIRTGHVALRV FT LHDGTAVTGLLVVRPDGCGIISAPSVILATGGLGHLYSATTNPAGSTGDGIALGLWAGV FT AVSDLEFIQFHPTMLFAGRAGGRRPLITEAIRGEGAILVDRQGNSITAGVHPMGDLAPR FT DVVAAAIDARLKATGDPCVYLDARGIEGFASRFPTVTASCRAAGIDPVRQPIPVVPGAH FT YSCGGIVTDVYGQTELLGLYAAGEVARTGLHGANRLASNSLLEGLVVGGRAGKAAAAHA FT AAAGRSRATSSATWPEPISYTALDRGDLQRAMSRDASMYRAAAGLHRLCDSLSGAQVRD FT VACRRDFEDVALTLVAQSVTAAALARTESRGCHHRAEYPCTVPEQARSIVVRGADDANA FT VCVQALVAVC" FT CDS 168754..169611 FT /transl_table=11 FT /gene="nadC" FT /locus_tag="Mb1622" FT /product="Probable nicotinate-nucleotide pyrophosphatase FT nadC" FT /EC_number="2.4.2.19" FT /note="Mb1622, nadC, len: 285 aa. Equivalent to Rv1596, FT len: 285 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 285 aa overlap). Probable nadC, FT nicotinate-nucleotide pyrophosphatase (EC 2.4.2.19) O06594. FT Similar to many e.g. ADC_MYCLE|P46714 from Mycobacterium FT leprae (284 aa), FASTA results: opt: 1418, E(): 0,(79.2% FT identity in 283 aa overlap). BELONGS TO THE NADC/MODD FT FAMILY." FT /db_xref="GOA:Q7VEW9" FT /db_xref="HSSP:1O4U" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:Q7VEW9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96290.1" FT /translation="MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASL FT VTREAGVVAGLDVALLTLDEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLTAE FT RTMLNLVGHLSGIATATAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVNHRL FT GLGDAALIKDNHVAAAGSVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPELILLD FT NFAVWQTQTAVQRRDSRAPTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDI FT GLDM" FT CDS 169660..170418 FT /transl_table=11 FT /gene="Mb1623" FT /locus_tag="Mb1623" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1623, -, len: 252 aa. Equivalent to Rv1597, len: FT 252 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 252 aa overlap). Hypothetical unknown FT protein." FT /db_xref="GOA:Q7TZW3" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q7TZW3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96291.1" FT /translation="MARTFEDLVAEAASASVGGWDFSWLDGRATEERPSWGYQRQLSQR FT LANATAALDLETGGGEVLAGAGNFPPTMVATEAWPPNAAMATRRLHPLGAVVVITGDKP FT PLPFADAAFDLVTSRHPSTRWWTEIARVLRAGGSYFAQHVGPATLWDLREHFLGPREHN FT GADQYAQVVRTCITDAGLEIVDLQMERLRVEFFDVGAVIYFLRKVIWFLPDFTVEGYHD FT RLRALHERIQAEGPFVTYSTRALIEARKPS" FT CDS complement(170439..170849) FT /transl_table=11 FT /gene="Mb1624c" FT /locus_tag="Mb1624c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1624c, -, len: 136 aa. Equivalent to Rv1598c, len: FT 136 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 136 aa overlap). Conserved hypothetical FT protein, some similarity to O06389|Rv0523c|MTCY25D10.02 FT from Mycobacterium tuberculosis (131 aa), FASTA scores: FT E(): 2.2e-09, (38.4% identity in 99 aa overlap); and FT P95144|MTCY359.02|Rv1871c (129 aa)." FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/TrEMBL:Q7TZW2" FT /protein_id="CAD96292.1" FT /translation="MSAKDHPNNAPGVPMVFPLWLERLQVKYINRALKPIARYLPGTAT FT IEHRGRKSGKPYQTIVTAYRKDGVLAIALAHGKTDWVKNVLAAGEADVHFARGVVHVIN FT PRIVPAGSDGQGLPRMARLQLRRIGVFVGDIA" FT CDS 170949..172265 FT /transl_table=11 FT /gene="hisD" FT /locus_tag="Mb1625" FT /product="Probable histidinol dehydrogenase HisD (HDH)" FT /EC_number="1.1.1.23" FT /note="Mb1625, hisD, len: 438 aa. Equivalent to Rv1599, FT len: 438 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 438 aa overlap). Probable hisD, FT histidinol dehydrogenase (EC 1.1.1.23) (see citation below) FT O08396. Similar to many e.g. HISX_MYCSM|P28736 from FT Mycobacterium smegmatis (445 aa), FASTA results: opt: 2356, FT E(): 0, (83.1% identity in 437 aa overlap). Contains FT histidinol dehydrogenase signature (PS00611)." FT /db_xref="GOA:P63951" FT /db_xref="HSSP:1K75" FT /db_xref="InterPro:IPR001692" FT /db_xref="UniProtKB/Swiss-Prot:P63951" FT /protein_id="CAD96293.1" FT /translation="MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAER FT GAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVMVERTRAVHSGQRRT FT DVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQ FT AQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNI FT YVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPS FT EDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQ FT TADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGI FT HVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER" FT CDS 172262..173404 FT /transl_table=11 FT /gene="hisC1" FT /locus_tag="Mb1626" FT /standard_name="hisC" FT /product="Probable histidinol-phosphate aminotransferase FT hisC1" FT /EC_number="2.6.1.9" FT /note="Mb1626, hisC1, len: 380 aa. Equivalent to Rv1600, FT len: 380 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 380 aa overlap). Probable hisC1, FT histidinol-phosphate aminotransferase (EC 2.6.1.9) O06591. FT Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces FT coelicolor (369 aa), FASTA results: opt: 1353, E(): 0, FT (59.0% identity in 356 aa overlap). Some similarity to FT other Mycobacterium tuberculosis aminotransferases e.g. FT Rv3772|MTCY13D12.06, FASTA results: E(): 7.4e-25, (33.7% FT identity in 365 aa overlap). Contains aminotransferases FT class-II pyridoxal-phosphate attachment site (PS00599). FT BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES. Note that previously known as hisC." FT /db_xref="GOA:P0A679" FT /db_xref="HSSP:1FG7" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P0A679" FT /protein_id="CAD96294.1" FT /translation="MTRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPP FT TRALVDDVVRSVREAAIDLHRYPDRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNE FT ILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAAVVD FT RKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPS FT KLVVTRTMSKAFAFAGGRLGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDT FT LSSVAALIAERERVTTSLNDMGFRVIPSDANFVLFGEFADAPAAWRRYLEAGILIRDVG FT IPGYLRATTGLAEENDAFLRASARIATDLVPVTRSPVGAP" FT CDS 173401..174033 FT /transl_table=11 FT /gene="hisB" FT /locus_tag="Mb1627" FT /product="Probable imidazole glycerol-phosphate dehydratase FT hisB" FT /EC_number="4.2.1.19" FT /note="Mb1627, hisB, len: 210 aa. Equivalent to Rv1601, FT len: 210 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 210 aa overlap). Probable hisB, imidazole FT glycerol-phosphate dehydratase (EC 4.2.1.19). Similar to FT many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor FT (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity FT in 202 aa overlap). BELONGS TO THE FT IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE FAMILY." FT /db_xref="GOA:P64369" FT /db_xref="InterPro:IPR000807" FT /db_xref="UniProtKB/Swiss-Prot:P64369" FT /protein_id="CAD96295.1" FT /translation="MTTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFY FT DHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAF FT IPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARI FT ALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL" FT CDS 174030..174650 FT /transl_table=11 FT /gene="hisH" FT /locus_tag="Mb1628" FT /product="Probable amidotransferase hisH" FT /EC_number="2.4.2.-" FT /note="Mb1628, hisH, len: 206 aa. Equivalent to Rv1602, FT len: 206 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 206 aa overlap). Probable hisH, FT amidotransferase (EC 2.4.2.-). Similar to many e.g. FT HIS5_STRCO|P16249 from Streptomyces coelicolor (222 aa), FT FASTA results: opt: 872, E():0, (61.0% identity in 210 aa FT overlap). Contains glutamine amidotransferases class-I FT active site (PS00442). BELONGS TO THE HISH FAMILY." FT /db_xref="GOA:P59957" FT /db_xref="InterPro:IPR016226" FT /db_xref="UniProtKB/Swiss-Prot:P59957" FT /protein_id="CAD96296.1" FT /translation="MTAKSVVVLDYGSGNLRSAQRALQRVGAEVEVTADTDAAMTADGL FT VVPGVGAFAACMAGLRKISGERIIAERVAAGRPVLGVCVGMQILFACGVEFGVQTPGCG FT HWPGAVIRLEAPVIPHMGWNVVDSAAGSALFKGLDVDARFYFVHSYAAQRWEGSPDALL FT TWATYRAPFLAAVEDGALAATQFHPEKSGDAGAAVLSNWVDGL" FT CDS 174660..175397 FT /transl_table=11 FT /gene="hisA" FT /locus_tag="Mb1629" FT /product="PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE FT CARBOXAMIDE RIBOTIDE ISOMERASE HISA" FT /EC_number="5.3.1.16" FT /note="Mb1629, hisA, len: 245 aa. Equivalent to Rv1603, FT len: 245 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 245 aa overlap). Probable hisA, FT PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE FT RIBOTIDE ISOMERASE (EC 5.3.1.16), similar to many e.g. FT HIS4_STRCO|P16250 phosphoribosylformimino-5-aminoimidaz FT from Streptomyces coelicolor (240 aa), FASTA scores: opt: FT 1081, E(): 0, (69.0% identity in 239 aa overlap)." FT /db_xref="GOA:P60579" FT /db_xref="InterPro:IPR010188" FT /db_xref="UniProtKB/Swiss-Prot:P60579" FT /protein_id="CAD96297.1" FT /translation="MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDG FT AEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVG FT TAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEG FT CSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEG FT AIVGKALYARRFTLPQALAAVRD" FT CDS 175405..176217 FT /transl_table=11 FT /gene="impA" FT /locus_tag="Mb1630" FT /product="PROBABLE INOSITOL-MONOPHOSPHATASE IMPA (IMP)" FT /EC_number="3.1.3.25" FT /note="Mb1630, impA, len: 270 aa. Equivalent to Rv1604, FT len: 270 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.9% identity in 270 aa overlap). Probable impA, inositol FT monophosphatase (EC 3.1.3.25), similar to many e.g. FT AF0059|AF005905_2 inositol monophosphate phosphatase from FT Mycobacterium smegmatis (276 aa), FASTA scores: opt: 1241, FT E(): 0, (70.5% identity in 261 aa overlap). Also similar to FT Mycobacterium tuberculosis proteins Rv3137 and Rv2701c." FT /db_xref="GOA:Q7TZW1" FT /db_xref="InterPro:IPR017955" FT /db_xref="UniProtKB/TrEMBL:Q7TZW1" FT /protein_id="CAD96298.1" FT /translation="MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATE FT VDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINHAAGSPLAAILL FT GLLHDGVPVAGLTWMPFTDQRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFSADS FT RGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVA FT LVRAAGGVVTDLAGQPWTPASRSALAGPLRVHAQILEILGSIGEPEDY" FT CDS 176219..177022 FT /transl_table=11 FT /gene="hisF" FT /locus_tag="Mb1631" FT /product="Probable cyclase hisF" FT /note="Mb1631, hisF, len: 267 aa. Equivalent to Rv1605, FT len: 267 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 267 aa overlap). Probable hisF, cyclase FT involved in histidine biosynthetic pathway, similar to many FT e.g. AF0304|AF030405_1 Corynebacterium glutamicum cyclase FT (257 aa), FASTA scores: opt: 1201, E(): 0, (71.9% identity FT in 256 aa overlap). BELONGS TO THE HISA / HISF FAMILY." FT /db_xref="GOA:Q7VEW8" FT /db_xref="InterPro:IPR004651" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEW8" FT /protein_id="CAD96299.1" FT /translation="MYADRDLPGAGGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVE FT LAAVYDAEGADELTFLDVTASSSGRATMLEVVRRTAEQVFIPLTVGGGVRTVADVDSLL FT RAGADKVAVNTAAIACLDLLADMARQFGSQCIVLSVDARTVPVGSAPTPSGWEVTTHGG FT RRGTGMDAVQWAARGADLGVGEILLNSMDADGTKAGFDLALLRAVRAAVTVPVIASGGA FT GAVEHFAPAVAAGADAVLAASVFHFRELTIGQVKAALAAEGITVR" FT CDS 177019..177366 FT /transl_table=11 FT /gene="hisI" FT /locus_tag="Mb1632" FT /product="Probable phosphoribosyl-AMP 1,6 cyclohydrolase FT hisI" FT /EC_number="3.5.4.19" FT /note="Mb1632, hisI, len: 115 aa. Equivalent to Rv1606, FT len: 115 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 115 aa overlap). Probable hisI, FT phosphoribosyl-AMP 1,6 cyclohydrolase (EC 3.5.4.19), FT similar to several e.g. X82010|RSHISI_2 HISI from FT Rhodobacter sphaeroides (119 aa), FASTA scores: opt: 378, FT E(): 2.8e-21, (52.3% identity in 109 aa overlap); etc." FT /db_xref="GOA:P0A5B4" FT /db_xref="InterPro:IPR002496" FT /db_xref="UniProtKB/Swiss-Prot:P0A5B4" FT /protein_id="CAD96300.1" FT /translation="MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALART FT LQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSC FT FDAAVLLEPDD" FT CDS 177547..178629 FT /transl_table=11 FT /gene="chaA" FT /locus_tag="Mb1633" FT /product="Probable ionic transporter integral membrane FT protein chaA" FT /note="Mb1633, chaA, len: 360 aa. Equivalent to Rv1607, FT len: 360 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 360 aa overlap). Probable chaA, ionic FT transporter integral membrane protein, putative FT calcium/proton antiporter, similar to many e.g. FT P31801|CHAA_ECOLI CALCIUM/PROTON ANTIPORTER from FT Escherichia coli (366 aa), FASTA scores: opt: 736, E(): 0, FT (35.9% identity in 351 aa overlap). Equivalent to FT Mycobacterium leprae AL049913|MLCB1610_21 (77.7% identity FT in 364 aa overlap). SEEMS TO BELONG TO THE CaCA FAMILY." FT /db_xref="GOA:Q7VEW7" FT /db_xref="InterPro:IPR004837" FT /db_xref="UniProtKB/TrEMBL:Q7VEW7" FT /protein_id="CAD96301.1" FT /translation="MLKRVPWTVVLPSLAFVALVLTWGKQIGPVVGLLAAVLLAGAVLA FT AVNHAEVVAARVGEPFGSLVLAVAVTTIEVALIVALMVSGGDDAATLARDTVFAAVMIT FT TNGIAGLSLLLGSLRYGVTLFNPHGSGAALATVTTLATLSLVLPTFTTSQSGPELSPGQ FT LIFAGAASLGLYVLFLFTQTVRHRDFFLPVAQKGAVEDDSHADPPSTRAALLSLGLLLV FT ALVAVVGLAKVESPVIEEVVSAAGFPQSFVGVVIATLVLLPETLAAARAARQGRLQTSL FT NLAYGSAMASIGLTIPTIALASLWLSGPLQLGLGAIQLVLLVLTVVVSVLTVVPGRATR FT LQGEVHLVLLAAYLFLAVVP" FT CDS complement(178664..179128) FT /transl_table=11 FT /gene="bcpB" FT /locus_tag="Mb1634c" FT /product="Probable peroxidoxin bcpB" FT /note="Mb1634c, bcpB, len: 154 aa. Equivalent to Rv1608c, FT len: 154 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 154 aa overlap). Probable bcpB, FT peroxidoxin or bacterioferritin comigratory protein, FT similar to many, e.g. AE0003|ECAE000335_4 bacterioferritin FT comigratory protein from Escherichia coli K-12 MG1655 (156 FT aa), FASTA scores: opt: 329, E(): 1.2e-16, (38.2% identity FT in 152 aa overlap); Z97179|MLCL383_22 Mycobacterium leprae FT cosmid L383 (161 aa) (40.2% identity in 132 aa overlap). FT Also similar to Rv2428 AhpC, alkyl hydroperoxide reductase FT from Mycobacterium tuberculosis; and other Mycobacterium FT tuberculosis putative peroxidoxins Rv2521, Rv2238c, FT Rv1932." FT /db_xref="GOA:Q7VEW6" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/TrEMBL:Q7VEW6" FT /protein_id="CAD96302.1" FT /translation="MKTGDTVADFELPDQTGTPRRLSVLLSDGPVVLFFYPAAMTPGCT FT KEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVRRFDYPLLSDAQGTVAAQFGVK FT RGLLGKLMPVKRTTFVIDTDRKVLDVISSEFSMDAHADKALATLRAIRSG" FT CDS 179269..180819 FT /transl_table=11 FT /gene="trpE" FT /locus_tag="Mb1635" FT /product="Probable anthranilate synthase component I trpE FT (GLUTAMINE AMIDOTRANSFERASE)" FT /EC_number="4.1.3.27" FT /note="Mb1635, trpE, len: 516 aa. Equivalent to Rv1609, FT len: 516 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 516 aa overlap). Probable trpE, FT anthranilate synthase component I (EC 4.1.3.27). FASTA FT best: TRPE_CLOTM|P14953 anthranilate synthase component I FT from Clostridium thermocellum (494 aa), E(): 0, (42.6% FT identity in 498 aa overlap). Some similarity to FT Rv2386c|MTCY253.35, E(): 6.3e-17; and Rv3215|MTCY07D11.11c, FT E(): 5.7e-15. BELONGS TO THE ANTHRANILATE SYNTHASE FT COMPONENT I FAMILY." FT /db_xref="GOA:P67002" FT /db_xref="HSSP:1K0E" FT /db_xref="InterPro:IPR015890" FT /db_xref="UniProtKB/Swiss-Prot:P67002" FT /protein_id="CAD96303.1" FT /translation="MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLA FT ANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLRAL FT QVTLELLATADRQSEPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLAT FT DVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSR FT PEPRHRAQRTVEEYGAIVEYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNP FT SPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEK FT ELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGE FT GRTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAI FT RTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC" FT CDS 180809..181516 FT /transl_table=11 FT /gene="Mb1636" FT /locus_tag="Mb1636" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb1636, -, len: 235 aa. Equivalent to Rv1610, len: FT 235 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 235 aa overlap). Possible conserved membrane FT protein. Equivalent to AL049913|MLCB1610_23 hypothetical FT protein from Mycobacterium leprae (264 aa), FASTA score: FT (65.8% identity in 231 aa overlap)." FT /db_xref="InterPro:IPR019051" FT /db_xref="UniProtKB/TrEMBL:Q7TZW0" FT /protein_id="CAD96304.1" FT /translation="MAANAGSVRPNRRARPMIGIAQLLLVVAAGALWMAARLPWVVIGS FT FDELGPPKEVTLTGASWSTALLPLALLMLAAAVAALAVRGWPLRALAVLLAAASFAVGY FT LGISLWVVPDVAARGADLAHVPVVTLVGSARHYWGAVAAVLAAVCALLAAVFLMSSAAI FT RGSAGEDMARYAAPRARRSIARRQHSNAAGRAAPQDDGPDMGPRMSERMIWEALDEGRD FT PTDREQESDTEGR" FT CDS 181606..182424 FT /transl_table=11 FT /gene="trpC" FT /locus_tag="Mb1637" FT /product="Probable indole-3-glycerol phosphate synthase FT trpC" FT /EC_number="4.1.1.48" FT /note="Mb1637, trpC, len: 272 aa. Equivalent to Rv1611, FT len: 272 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 272 aa overlap). Probable trpC, FT indole-3-glycerol phosphate synthase (EC 4.1.1.48). Similar FT to Q55508|SLR0546 HYPOTHETICAL 33.0 KD PROTEIN from FT SYNECHOCYSTIS SP (295 aa), FASTA score: opt: 26, E(): FT 7.6e-32, (44.2% identity in 265 aa overlap); also similar FT to TRPC_AZOBR|P26938 indole-3-glycerol-phosphate FT synthaseindole-3-glycerol-phosphate synthase from FT Azospirillum brasilense (262 aa), FASTA score: opt: 596, FT E(): 4.8e-30, (43.8% identity in 258 aa overlap). FT Equivalent to AL0499 13|MLCB1610_24 from Mycobacterium FT leprae (272 aa) (90.8% identity in 272 aa overlap). FT Contains indole-3-glycerol phosphate synthase signature FT (PS00614). BELONGS TO THE TRPC FAMILY." FT /db_xref="GOA:P0A633" FT /db_xref="HSSP:1PII" FT /db_xref="InterPro:IPR001468" FT /db_xref="UniProtKB/Swiss-Prot:P0A633" FT /protein_id="CAD96305.1" FT /translation="MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMA FT ALREPGIGVIAEVKRASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDD FT LDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGM FT TALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGV FT RGTADLLAYAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR" FT CDS 182493..183725 FT /transl_table=11 FT /gene="trpB" FT /locus_tag="Mb1638" FT /product="Probable tryptophan synthase, beta subunit trpB" FT /EC_number="4.2.1.20" FT /note="Mb1638, trpB, len: 410 aa. Equivalent to Rv1612, FT len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 410 aa overlap). Probable trpB, FT tryptophan synthase beta chain (EC 4.2.1.20). Equivalent to FT AL049913|MLCB1610_25 from Mycobacterium leprae (340 aa) FT (88.5% identity in 331 aa overlap). Similar to others e.g. FT TRPB_CAUCR|P12290 tryptophan synthase beta chain from FT Caulobacter crescentus (406 aa), FASTA scores: opt: 1662, FT E(): 0, (60.6% identity in 404 aa overlap). BELONGS TO THE FT TRPB FAMILY. TETRAMER OF TWO ALPHA AND TWO BETA CHAINS." FT /db_xref="GOA:P66985" FT /db_xref="HSSP:2WSY" FT /db_xref="InterPro:IPR001926" FT /db_xref="UniProtKB/Swiss-Prot:P66985" FT /protein_id="CAD96306.1" FT /translation="MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAY FT QKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKINN FT VLGQALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTARQALNVARM FT RLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRII FT GMEARVQIQGQAGRLPDAVVACVGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRH FT AATFTAGSPGAFHGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKEAGRVDYRP FT ITDSEAMDAFGLLCRMEGIIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVET FT AAKWFGLLGND" FT CDS 183725..184537 FT /transl_table=11 FT /gene="trpA" FT /locus_tag="Mb1639" FT /product="Probable tryptophan synthase, alpha subunit trpA" FT /EC_number="4.2.1.20" FT /note="Mb1639, trpA, len: 270 aa. Equivalent to Rv1613, FT len: 270 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 270 aa overlap). Probable trpA, FT tryptophan synthase alpha chain (EC 4.2.1.20). FASTA best: FT O68906|TRPA_MYCIT TRYPTOPHAN SYNTHASE ALPHA CHAIN from FT Mycobacterium intracellulare (271 aa), opt: 1442, E(): 0, FT (85.3% identity in 265 aa overlap)." FT /db_xref="GOA:P66981" FT /db_xref="HSSP:1GEQ" FT /db_xref="InterPro:IPR002028" FT /db_xref="UniProtKB/Swiss-Prot:P66981" FT /protein_id="CAD96307.1" FT /translation="MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAM FT TALVESGCDIIEVGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAGGRAV FT VMTYWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASEEHRLDRIFLVAPS FT STPERLAATVEASRGFVYAASTMGVTGARDAVSQAAPELVGRVKAVSDIPVGVGLGVRS FT RAQAAQIAQYADGVIVGSALVTALTEGLPRLRALTGELAAGVRLGMSA" FT CDS 184537..185943 FT /transl_table=11 FT /gene="lgt" FT /locus_tag="Mb1640" FT /product="Possible prolipoprotein diacylglyceryl FT transferases Lgt" FT /EC_number="2.4.99.-" FT /note="Mb1640, lgt, len: 468 aa. Equivalent to Rv1614, len: FT 468 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 468 aa overlap). Possible lgt, prolipoprotein FT diacylglyceryl transferases (EC 2.4.99.-), similar to many FT prolipoprotein diacylglyceryl transferases. FASTA scores: FT LGT_STAAU|P52282 prolipoprotein diacylglyceryl transferase FT from Staphylococcus aureus subsp. (279 aa), opt: 289, FT E():3.6e- 09, (31.5% identity in 257 aa overlap); FT AL096884|SC4G6_3 cosmid 4G6 from Streptomyces coelicolor FT (343 aa), opt: 735, E(): 4e-32, (46.5% identity in 391 aa FT overlap)." FT /db_xref="GOA:Q7VEW5" FT /db_xref="InterPro:IPR001640" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEW5" FT /protein_id="CAD96308.1" FT /translation="MRMLPSYIPSPPRGVWYLGPLPVRAYAVCVITGIIVALLIGDRRL FT TARGGERGMTYDIALWAVPFGLIGGRLYHLATDWRTYFGDGGAGLAAALRIWDGGLGIW FT GAVTLGVMGAWIGCRRCGIPLPVLLDAVAPGVVLAQAIGRLGNYFNQELYGRETTMPWG FT LEIFYRRDPSGFDVPNSLDGVSTGQVAFVVQPTFLYELIWNVLVFVALIYIDRRFIIGH FT GRLFGFYVAFYCAGRFCVELLRDDPATLIAGIRINSFTSTFVFIGAVVYIILAPKGREA FT PGALRGSEYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEV FT TDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPE FT EPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDDPAEPDGIRRQDDFSSRRR FT RWWRLRRRRQ" FT CDS 186619..187059 FT /transl_table=11 FT /gene="Mb1641" FT /locus_tag="Mb1641" FT /product="hypothetical membrane protein" FT /note="Mb1641, -, len: 146 aa. Equivalent to Rv1615, len: FT 146 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 146 aa overlap). Probable membrane protein." FT /db_xref="InterPro:IPR007829" FT /db_xref="UniProtKB/TrEMBL:Q7VEW4" FT /protein_id="CAD96309.1" FT /translation="MGLRPARVVRPARSGMLKGVTDPLQHGAFEPGWQSAPPGYPPPYP FT QYPGPGSYFDPFAPYGRHPVTGQPFSDKSKTVAGLLQLLGLFGIAGIGRIYLGHTGLGI FT AQLLVGWVTCGLGAVIWGVIDALLILTDKVGDPWGRPLRDGS" FT CDS 187049..187447 FT /transl_table=11 FT /gene="Mb1642" FT /locus_tag="Mb1642" FT /product="CONSERVED MEMBRANE PROTEIN" FT /note="Mb1642, -, len: 132 aa. Equivalent to Rv1616, len: FT 132 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 132 aa overlap). Conserved membrane protein, FT with some similarity to other hypothetical proteins e.g. FT AL096884|SC4G6_9 from Streptomyces coelicolor cosmid 4G6 FT (148 aa), FASTA scores: opt: 245, E(): 1.7e-1 0, (36.7% FT identity in 128 aa overlap); Q55401|SLL0543 HYPOTHETICAL FT 16.5 KD PROTEIN from SYNECHOCYSTIS SP (148 aa), FASTA FT scores: opt: 225, E(): 6.5e-10, (35.9% identity in 117 aa FT overlap). Has cysteine cluster and contains a rubredoxin FT signature (PS00202)." FT /db_xref="InterPro:IPR018527" FT /db_xref="UniProtKB/TrEMBL:Q7TZV9" FT /protein_id="CAD96310.1" FT /translation="MEASGRQRRYAAAGSVVLLAGALGYIGLVDPHNSNSLYPPCLFKL FT LTGWNCPACGGLRMIHDLLHGELAASINDNVFLLVGVPVLASWVLLRRRHGDLALPIPV FT MIAVAVAVIAWTVLRNLPGFPLVPTISG" FT CDS 187555..188973 FT /transl_table=11 FT /gene="pykA" FT /locus_tag="Mb1643" FT /product="Probable pyruvate kinase pykA" FT /EC_number="2.7.1.40" FT /note="Mb1643, pykA, len: 472 aa. Equivalent to Rv1617, FT len: 472 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 472 aa overlap). Probable pykA, pyruvate FT kinase (EC 2.7.1.40). FASTA best: Q46078 PYRUVATE KINASE FT from CORYNEBACTERIUM GLUTAMICUM (475 aa), opt: 2221, E(): FT 0, (72.2% identity in 468 aa overlap). BELONGS TO THE FT PYRUVATE KINASE FAMILY." FT /db_xref="GOA:Q7VEW3" FT /db_xref="HSSP:1E0T" FT /db_xref="InterPro:IPR015794" FT /db_xref="UniProtKB/TrEMBL:Q7VEW3" FT /protein_id="CAD96311.1" FT /translation="MTRRGKIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHK FT VAYERVRVASDATGRAVGVLADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSHDR FT VSTTYKRLAQDAVAGDRVLVDDGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLPGMN FT VTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAKLDKP FT EAIDNLEAIVLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDS FT MIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAA FT PPLTHIPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWP FT EVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGS FT TNLIHVHRIGEDDV" FT CDS 188981..189883 FT /transl_table=11 FT /gene="tesB1" FT /locus_tag="Mb1644" FT /product="Probable acyl-CoA thioesterase II tesB1" FT /EC_number="3.1.2.-" FT /note="Mb1644, tesB1, len: 300 aa. Equivalent to Rv1618, FT len: 300 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 300 aa overlap). Probable tesB1, FT acyl-CoA thioesterase II (EC 3.1.2.-), similar to other FT acyl-CoA thioesterases e.g. TESB_ECOLI|P23911 acyl-coa FT thioesterase II from Escherichia coli (285 aa), FASTA FT scores: opt: 495, E(): 2.9e-27, (32.5% identity in 283 aa FT overlap); etc. Also similar to Rv2605c|tesB2 from M. FT tuberculosis." FT /db_xref="GOA:Q7VEW2" FT /db_xref="HSSP:1C8U" FT /db_xref="InterPro:IPR003703" FT /db_xref="UniProtKB/TrEMBL:Q7VEW2" FT /protein_id="CAD96312.1" FT /translation="MPDGKPMSDFDELLAVLDLNAVASDLFTGSHPSKNPLRTFGGQLM FT AQSFVASSRTLTRHHLPPSAFSVHFINGGDTAKDIEFQVIRLRDERRFANRRVDAVQDG FT TLLSSAMVSYMAGGRGLEHALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWR FT YANDPAWIMRDKGDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLS FT WGFDRIFAASANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGKLIATVV FT QEGVLKYFPATPDSAAGRS" FT CDS 189941..191395 FT /transl_table=11 FT /gene="Mb1645" FT /locus_tag="Mb1645" FT /product="CONSERVED MEMBRANE PROTEIN" FT /note="Mb1645, -, len: 484 aa. Equivalent to Rv1619, len: FT 484 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 484 aa overlap). Conserved membrane protein. FT Some similarity to N-terminus of FT P94974|Rv1640c|MTCY06H11.04c PROBABLE LYSYL-TRNA SYNTHETASE FT 2 (EC 6.1.1.6) from Mycobacterium tuberculosis (1172 aa), FT FASTA scores: E(): 1.4e-16, (28.0% identity in 410 aa FT overlap); and similar in part to O69916| SC3C8.03C Putative FT intergral membrane protein from Streptomyces coelicolor FT cosmid 3C8 (589 aa), FASTA scores: opt: 453 E(): 8.4e-22, FT (31.3% identity in 313 aa overlap)." FT /db_xref="InterPro:IPR007426" FT /db_xref="UniProtKB/TrEMBL:Q7TZV8" FT /protein_id="CAD96313.1" FT /translation="MVAAAGEPLNCQRANPEVTVKLPSADVVPRLRGRQRVVVHVDSRT FT ARCVGALALVCAACWLIALLAGDYRHAQWAVAGRLGWSLTVLAAVAFIARGIFLGRPVT FT AMHATAAGLFLLAGLAAHVLVADLLGEILIAGSGWALMWPTSAHPRPEDLPRVWALINA FT TRADSLAPFAMQAGKSHHFSAAGTAALAYRTRIGYAVVSGDPIGDEAQFPQLVADFAAM FT CHMHGWRIVVVGCSERRLGLWSDPMVVGQSLRPIPIGRDVVIDVSNFEMTGRRFRNLRQ FT AVKRTHNFGVTTEIVAEQQLDDQRQAELAEVLAASPSGARTDRGFCMNLDGVLEGRYPG FT IQLIIARDASGRVQGFHRYATAGGGSDMSLDVPWRRRGAPNGIDERLSADMIAAAKDAG FT VQRLSLAFAAFPDLFGANQLGRLQRVCRALIHILDPLIALESLYRYLRKFHALDERRYV FT LISMTQVFALALVLLSLEFVPRRRHL" FT CDS complement(191329..193059) FT /transl_table=11 FT /gene="cydC" FT /locus_tag="Mb1646c" FT /product="PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF FT CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC FT TRANSPORTER CYDC" FT /note="Mb1646c, cydC, len: 576 aa. Equivalent to Rv1620c, FT len: 576 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 576 aa overlap). Probable cydC, FT transmembrane ATP-binding protein ABC transporter involved FT in transport of component linked with the assembly of FT cytochrome (see citation below), similar to others e.g. FT CYDC_ECOLI|P23886 transport ATP-binding protein from FT Escherichia coli (573 aa), FASTA scores: opt: 631, E(): FT 1.6e-30, (28.5% identity in 569 aa overlap); C-terminal FT part of AL034355|SCD78_14 from Streptomyces coelicolor FT (1172 aa), FASTA scores: opt: 956, E(): 0, (38.8% identity FT in 554 aa overlap); etc. Contains (PS00211) ABC FT transporters family signature, and (PS00017) FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7TZV7" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TZV7" FT /protein_id="CAD96314.1" FT /translation="MNRPSAVSRRQRDLLAASGLLGPRLPRILAAVALGVLSLGSALAL FT AGVSAWLITRAWQMPPVLDLSVAVVAVRAFAISRGVLHYCERLATHDTALRAAGRARTL FT IYHRLAHGPAAAAVGLHSGDLAARVGADVDELANMLVRALVPIAVAAVLAVAATAVVAA FT VSVPAAVVLAVCLLVAGVVAPWLAGRTAAAQEAIARQHRGMRDTSAMIALEHAPELRVA FT GALRNVIADSQRRQHAWADALDAAARTGAIAEAMPTAAIGASLLGAVVAGIGMAPTVAP FT TTLAILMLLPLSAFEATVALPAAAVQLTRSRIAAARLLDLTGSNRVRETESTVSARLPV FT GTGVLAADVCCGHQEAQSIRVTIDLPPGARLAVTGASGAGKTTLLMTLAGLLPPVHGRV FT LLDGTNLSDFDEDELRSAVSFFAEDAHIFATTVRDNLLTARGDCPDDELIEALDRVGLC FT GWLAGLPEGLSTVLIGGAQAVSAGQRRRLLLARAVLSPARIVLLDEPVEHLDAANADLL FT RDLLAPNSGIMSAMRTVVVATHHLPNDIQCAELSIATDQRCRRRGTNSSDNNTNASAKT FT " FT CDS complement(193056..194639) FT /transl_table=11 FT /gene="cydD" FT /locus_tag="Mb1647c" FT /product="PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF FT CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC FT TRANSPORTER CYDD" FT /note="Mb1647c, cydD, len: 527 aa. Equivalent to Rv1621c, FT len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 527 aa overlap). Probable cydD, FT transmembrane ATP-binding protein ABC transporter involved FT in transport of component linked with the assembly of FT cytochrome (see citation below), similar to others e.g. FT P94366|CYDC_BACSU TRANSPORT ATP-BINDING PROTEIN from FT Bacillus subtilis (567 aa), FASTA scores: opt: 784, E(): 0, FT (30.1% identity in 535 aa overlap); N-terminal part of FT AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa), FT FASTA scores: opt: 1295, E(): 0, (44.6% identity in 534 aa FT overlap); etc. Also similar to Q11019|Y07D_MYCTU from FT Mycobacterium tuberculosis (579 aa), FASTA scores: opt: FT 530, E(): 6.9e-25, (29.1% identity in 530 aa overlap). FT Contains (PS00211) ABC transporters family signature, and FT (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO FT THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS)." FT /db_xref="GOA:Q7TZV6" FT /db_xref="HSSP:1R0W" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TZV6" FT /protein_id="CAD96315.1" FT /translation="MACGVGISGCAIGSAIVLASIVAGVIDPANPGMAGLRRWLGPLSI FT LLVLWGLRASIQWLQARLAQRGASAVIADLSGQVLTAVTARRPSQLAAQRDAAAVLITR FT GLDGLRPYFTGYLPTLLLAAILTPATVAVIGLYDLKSMAIVVITLPLIPIFMVLIGLAT FT TNPSAAALAAMTAVQARLLDLIAGIPTLRALGRASGPEQRIAELSADHRRSAMATLRIA FT FLSALVLELLATLGVALVAVGIGLRLVFGEMSLTAGLTVLLLAPEVYWPLRRVGVQFHA FT AADGRTAADKAFALLGESPSPTPGRRTVTARGGVIRLERLSVRGRDGRAPYDLTADIEP FT GRVTVLTGRNGAGKSTTLQAIAGLTAPSSGRITVAGVDVTNLAPAAWWRQLSWLPQRPV FT LVPGTVRHNLVLLGPVDDLERACAAAGFDAVLDELPRGLDTVLGRGGVGLSLGQRQRLG FT LARALGSPAAVLLLDEPTAHLDARTEQHVLGAIVERARAGATVLVVAHRQQVAAAGDRV FT VEVNSDGFRR" FT CDS complement(194726..195766) FT /transl_table=11 FT /gene="cydB" FT /locus_tag="Mb1648c" FT /product="Probable integral membrane cytochrome D ubiquinol FT oxidase (subunit II) cydB (Cytochrome BD-I oxidase subunit FT II)" FT /EC_number="1.10.3.-" FT /note="Mb1648c, cydB, len: 346 aa. Equivalent to Rv1622c, FT len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 346 aa overlap). Probable cydB, FT cytochrome D ubiquinol oxidase subunit II (EC 1.10.3.-), FT integral membrane protein, similar to others e.g. FT P11027|CYDB_ECOLI CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II FT from Escherichia coli strain K12 (379 aa), FASTA scores: FT opt: 519, E(): 0, (32.3% identity in 372 aa overlap); FT P94365|CYDB_BACSU CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II FT from Bacillus subtilis (338 aa), FASTA scores: opt: 824, FT E(): 0, (39.5% identity in 337 aa overlap); etc." FT /db_xref="GOA:Q7TZV5" FT /db_xref="InterPro:IPR003317" FT /db_xref="UniProtKB/TrEMBL:Q7TZV5" FT /protein_id="CAD96316.1" FT /translation="MVLQELWFGVIAALFLGFFILEGFDFGVGMLMAPFAHVGMGDPET FT HRRTALNTIGPVWDGNEVWLITAGAAIFAAFPGWYATVFSALYLPLLAILFGMILRAVA FT IEWRGKIDDPKWRTGADFGIAAGSWLPALLWGVAFAILVRGLPVDANGHVALSIPDVLN FT AYTLLGGLATAGLFSLYGAVFIALKTSGPIRDDAYRFAVWLSLPVAGLVAGFGLWTQLA FT YGKDWTWLVLAVAGCAQAAATVLVWRRVSDGWAFMCTLIVVAAVVVLLFGALYPNLVPS FT TLNPQWSLTIHNASSTPYTLKIMTWVTAFFAPLTVAYQTWTYWVFRQRISAERIPPPTG FT LARRAP" FT CDS complement(195796..197253) FT /transl_table=11 FT /gene="cydA" FT /locus_tag="Mb1649c" FT /standard_name="appC" FT /product="Probable integral membrane cytochrome D ubiquinol FT oxidase (subunit I) cydA (Cytochrome BD-I oxidase subunit FT I)" FT /EC_number="1.10.3.-" FT /note="Mb1649c, cydA, len: 485 aa. Equivalent to Rv1623c, FT len: 485 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 485 aa overlap). Probable cydA FT (previously known as appC, but renamed cydA to conform with FT Mycobacterium smegmatis nomenclature), cytochrome D FT ubiquinol oxidase subunit I (EC 1.10.3.-), integral FT membrane protein, similar to others e.g. FT P26459|APPC_ECOLI|CYXA|CBDA|B0978 CYTOCHROME BD-II OXIDASE FT SUBUNIT I from Escherichia coli strain K12 (514 aa), FASTA FT scores: opt: 870, E(): 0, (35.9% identity in 485 aa FT overlap); AL034355|SCD78_12 from Streptomyces coelicolor FT (501 aa), FASTA scores: opt: 1099, E(): 0, (48.6% identity FT in 510 aa overlap); etc." FT /db_xref="GOA:Q7TZV4" FT /db_xref="InterPro:IPR002585" FT /db_xref="UniProtKB/TrEMBL:Q7TZV4" FT /protein_id="CAD96317.1" FT /translation="MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVMQTLWVVTDNP FT AWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLAMEGLAAFF FT FESTFIGLWIFGWNRLPRLVHLACIWIVAIAVNVSAFFIIAANSFMQHPVGAHYNPTTG FT RAELSSIVVLLTNNTAQAAFTHTVSGALLTAGTFVAAVSAWWLVRSSTTHADSDTQAMY FT RPATILGCWVALAATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNFSVLTVGR FT QNNCDSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQRFGPNDYRPNLFVTYWS FT FRMMIGLMAIPVLFALIALWLTRGGQIPNQRWFSWLALLTMPAPFLANSAGWVFTEMGR FT QPWVVVPNPTGDQLVRLTVKAGVSDHSATVVATSLLMFTLVYAVLAVIWCWLLKRYIVE FT GPLEHDAEPAAHGAPRDDEVAPLSFAY" FT CDS complement(197364..197951) FT /transl_table=11 FT /gene="Mb1650c" FT /locus_tag="Mb1650c" FT /product="Probable conserved membrane protein" FT /note="Mb1650c, -, len: 195 aa. Equivalent to Rv1624c, len: FT 195 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 195 aa overlap). Probable membrane FT protein, first start taken. Some similarity to Rv3155 nuoK, FT NADH dehydrogenase chain K from Mycobacterium tuberculosis. FT Also similar to AAK72093.1|AF196488 hypothetical protein FT from Mycobacterium smegmatis (205 aa). Identities = 117/195 FT (60%)." FT /db_xref="InterPro:IPR005325" FT /db_xref="UniProtKB/TrEMBL:Q7VEW1" FT /protein_id="CAD96318.1" FT /translation="MCHTAPMEPSPVVSPLPRLLPHLWKSTLASGILSLILGVLVLAWP FT GISILVAAMAFGVYLLITGVAQVAFAFSLHVSAGGRILLFISGAASLILAVLAFRHFGD FT AVLLLAIWIGIGFIFRGVATTVSAISDPMLPGRGWSIFVGVISLIAGIVVMASPFESIW FT ILALVVGIWLVVIGACEIASSFAIRKASQTLG" FT CDS complement(197980..199236) FT /transl_table=11 FT /gene="cya" FT /locus_tag="Mb1651c" FT /product="MEMBRANE-ANCHORED ADENYLYL CYCLASE CYA (ATP FT PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE)" FT /EC_number="4.6.1.1" FT /note="Mb1651c, cya, len: 418 aa. Equivalent to Rv1625c, FT len: 418 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 418 aa overlap). cya, membrane-anchored FT adenylyl cyclase (EC 4.6.1.1) (see citations below). FT C-terminal half is similar to region in numerous eukaryotic FT adenylate and guanylate cyclases. N-terminal half FT hydrophobic. FASTA score: CYG2_RAT|P22717 guanylate cyclase FT soluble, beta-2 chain (682 aa), FASTA scores: opt: 552, FT E(): 2.7e-26, (40.3% identity in 226 aa overlap). Some FT similarity to Rv2435c|MTCY428.11 from Mycobacterium FT tuberculosis (730 aa), E(): 7e-19. Start changed since FT first submission (+25 aa). BELONGS TO ADENYLYL CYCLASE FT CLASS-4/GUANYLYL CYCLASE FAMILY." FT /db_xref="GOA:P0A4Y1" FT /db_xref="HSSP:1AZS" FT /db_xref="InterPro:IPR018297" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Y1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96319.1" FT /translation="MRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATG FT AGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFF FT FLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTV FT SACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKY FT DEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVS FT GVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYD FT VWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGR FT KVAADPGEVRGAEPRTAGV" FT tRNA complement(199381..199454) FT /gene="leuV" FT /locus_tag="leuV" FT /note="leuV, len: 74 nt. Equivalent to leuV, len: 74 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 74 nt overlap). tRNA-Leu, anticodon caa." FT CDS 199546..200163 FT /transl_table=11 FT /gene="Mb1652" FT /locus_tag="Mb1652" FT /product="Probable two-component system transcriptional FT regulator" FT /note="Mb1652, -, len: 205 aa. Equivalent to Rv1626, len: FT 205 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 205 aa overlap). Probable two-component FT response system transcriptional regulator, similar to many FT e.g. CHEY_BACSU|P24072 chemotaxis protein chey homolog (119 FT aa), FASTA scores: opt: 283, E(): 1.6e-16, (43.0% identity FT in 114 aa overlap). Also similar to AL109732|SC7H2_27 FT hypothetical protein from Streptomyces coelicolor (218 aa), FT opt: 880, E(): 0, (69.4% identity in 196 aa overlap)." FT /db_xref="GOA:Q7VEW0" FT /db_xref="HSSP:1OXK" FT /db_xref="InterPro:IPR005561" FT /db_xref="UniProtKB/TrEMBL:Q7VEW0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96320.1" FT /translation="MTGPTTDADAAVPRRVLIAEDEALIRMDLAEMLREEGYEIVGEAG FT DGQEAVELAELHKPDLVIMDVKMPRRDGIDAASEIASKRIAPIVVLTAFSQRDLVERAR FT DAGAMAYLVKPFSISDLIPAIELAVSRFREITALEGEVATLSERLETRKLVERAKGLLQ FT TKHGMTEPDAFKWIQRAAMDRRTTMKRVAEVVLETLGTPKDT" FT CDS complement(200231..201439) FT /transl_table=11 FT /gene="Mb1653c" FT /locus_tag="Mb1653c" FT /product="Probable nonspecific lipid-transfer protein" FT /note="Mb1653c, -, len: 402 aa. Equivalent to Rv1627c, len: FT 402 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 402 aa overlap). Probable nonspecific FT lipid-transfer protein, similar to many lipid carrier FT proteins e.g. Q51797 ACETYL CoA SYNTHASE from Pyrococcus FT furiosus (388 aa), FASTA scores: opt: 400, E(): 3.2e-18, FT (34.4% identity in 407 aa overlap); etc. Also some FT similarity to Mycobacterium tuberculosis proteins Rv3523, FT Rv3540c, Rv0244, Rv2790c, Rv1323, etc." FT /db_xref="GOA:Q7VEV9" FT /db_xref="InterPro:IPR002155" FT /db_xref="UniProtKB/TrEMBL:Q7VEV9" FT /protein_id="CAD96321.1" FT /translation="MRMSAPEPVYILGAGMHPWGKWGNDFTEYGVVAARAALRDAGVDW FT RHVQLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSARAQILA FT GFCDVALVIGADTTPKGFFAPVGGERKGDPDWQRFHLIGATNTVYFALLARRRMDLYGA FT TVEDFAQVKVKNSRHGLDNPNARYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALI FT VASKSFTEKHLGSVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQI FT LDAAYAEAGIGPEDLSLAEVYDLSTALELDWYEHLGLCPKGEAEALLRSGATTLGGRVP FT VNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVADAKVGVTANQGLFGHGSSVI FT VAR" FT CDS complement(201436..201927) FT /transl_table=11 FT /gene="Mb1654c" FT /locus_tag="Mb1654c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1654c, -, len: 163 aa. Equivalent to Rv1628c, len: FT 163 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 163 aa overlap). Conserved hypothetical FT protein, some similarity to others e.g. Q51796 ACAC PROTEIN FT in Pyrococcus furiosus (136 aa), FASTA scores: opt: 199, FT E(): 4.6e-06, (34.7% identity in 121 aa overlap)." FT /db_xref="InterPro:IPR002878" FT /db_xref="UniProtKB/TrEMBL:Q7TZV3" FT /protein_id="CAD96322.1" FT /translation="MPEVTREEPAIDGWFTTDKAGNPHLLGGKCPQCGTYVFPPRADNC FT PNPACGSDTLESVGLSTRGKLWSYTENRYAPPPPYPAPDPFEPFAVAAVELADEGLIVL FT GKVVDGTLAADLKVGMEMELTTMPLFADDDGVQRIVYAWRIPSRAGDDAERSDAEERRR FT " FT CDS 202031..204745 FT /transl_table=11 FT /gene="polA" FT /locus_tag="Mb1655" FT /product="DNA polymerase I polA" FT /EC_number="2.7.7.7" FT /note="Mb1655, polA, len: 904 aa. Equivalent to Rv1629, FT len: 904 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 904 aa overlap). polA, DNA polymerase I FT (EC 2.7.7.7). Has DNA polymerase family A signature FT (PS00447) at C-terminal end. FASTA best: DPO1_MYCTU|Q07700 FT DNA polymerase I from Mycobacterium tuberculosis (904 aa). FT Some similarity to Rv2090|MTCY49.30 (393 aa), E(): 2.2e-18, FT (38.7% identity in 292 aa overlap). BELONGS TO DNA FT POLYMERASE TYPE-A FAMILY." FT /db_xref="GOA:P0A551" FT /db_xref="HSSP:1BGX" FT /db_xref="InterPro:IPR018320" FT /db_xref="UniProtKB/Swiss-Prot:P0A551" FT /protein_id="CAD96323.1" FT /translation="MVTTASAPSEDRAKPTLMLLDGNSLAFRAFYALPAENFKTRGGLT FT TNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRLQRYPEYKANRSSTPDEFAGQIDI FT TKEVLGALGITVLSEPGFEADDLIATLATQAENEGYRVLVVTGDRDALQLVSDDVTVLY FT PRKGVSELTRFTPEAVVEKYGLTPRQYPDFAALRGDPSDNLPGIPGVGEKTAAKWIAEY FT GSLRSLVDNVDAVRGKVGDALRANLASVVRNRELTDLVRDVPLAQTPDTLRLQPWDRDH FT IHRLFDDLEFRVLRDRLFDTLAAAGGPEVDEGFDVRGGALAPGTVRQWLAEHAGDGRRA FT GLTVVGTHLPHGGDATAMAVAAADGEGAYLDTATLTPDDDAALAAWLADPAKPKALHEA FT KAAVHDLAGRGWTLEGVTSDTALAAYLVRPGQRSFTLDDLSLRYLRRELRAETPQQQQL FT SLLDDDDTDAETIQTTILRARAVIDLADALDAELARIDSTALLGEMELPVQRVLAKMES FT AGIAVDLPMLTELQSQFGDQIRDAAEAAYGVIGKQINLGSPKQLQVVLFDELGMPKTKR FT TKTGYTTDADALQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLQAVAADGRIHTTFNQ FT TIAATGRLSSTEPNLQNIPIRTDAGRRIRDAFVVGDGYAELMTADYSQIEMRIMAHLSG FT DEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKAMSYGLAYGLSAYGLSQQLK FT ISTEEANEQMDAYFARFGGVRDYLRAVVERARKDGYTSTVLGRRRYLPELDSSNRQVRE FT AAERAALNAPIQGSAADIIKVAMIQVDKALNEAQLASRMLLQVHDELLFEIAPGERERV FT EALVRDKMGGAYPLDVPLEVSVGYGRSWDAAAH" FT CDS 204908..206353 FT /transl_table=11 FT /gene="rpsA" FT /locus_tag="Mb1656" FT /product="PROBABLE RIBOSOMAL PROTEIN S1 RPSA" FT /note="Mb1656, rpsA, len: 481 aa. Equivalent to Rv1630, FT len: 481 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 481 aa overlap). Probable rpsA, FT ribosomal protein S1. FASTA best: RS1_MYCLE|P46836 30s FT ribosomal protein S1 from Mycobacterium leprae (482 aa), FT opt: 2655, E(): 0, (87.2% identity in 483 aa overlap)." FT /db_xref="GOA:Q7TZV2" FT /db_xref="HSSP:1GO3" FT /db_xref="InterPro:IPR003029" FT /db_xref="UniProtKB/TrEMBL:Q7TZV2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96324.1" FT /translation="MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIVK FT VDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSK FT KRAQYERAWGTIEALKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQP FT YIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSSIVNF FT GAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSLKATQE FT DPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAV FT GDDAMVKVIDIDLERRRISLSLKQANEDYTEEFDPAKYGMADSYDEQGNYIFPEGFDAE FT TNEWLEGFEKQRAEWEARYAEAERRHKMHTAQMEKFAAAETAGRGADDQSSASSAPSEK FT TAGGSLASDAQLAALREKLAGSA" FT CDS 206379..207602 FT /transl_table=11 FT /gene="coaE" FT /locus_tag="Mb1657" FT /product="Probable dephospho-CoA kinase coaE FT (dephosphocoenzyme A kinase)" FT /EC_number="2.7.1.24" FT /note="Mb1657, coaE, len: 407 aa. Equivalent to Rv1631, FT len: 407 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 407 aa overlap). Probable coaE, FT dephospho-CoA kinase (EC 2.7.1.24), similar to many e.g. FT Q50178|ML1383|COAE_MYCLE DEPHOSPHO-COA KINASE from FT Mycobacterium leprae (410 aa), FASTA scores: E(): 0, (77.5% FT identity in 409 aa overlap). Has ATP/GTP-binding site motif FT A (P-loop, PS00017) at N-terminus. IN THE N-TERMINAL FT SECTION; BELONGS TO THE COAE FAMILY. IN THE C-TERMINAL FT SECTION; BELONGS TO THE UPF0157 (GRPB) FAMILY." FT /db_xref="GOA:P63827" FT /db_xref="HSSP:1N3B" FT /db_xref="InterPro:IPR007344" FT /db_xref="UniProtKB/Swiss-Prot:P63827" FT /protein_id="CAD96325.1" FT /translation="MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEG FT LASLVDAFGRDILLADGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIAAVSG FT DAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQASDQ FT QRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPD FT QARRIVNRLKIACGHKALRVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPL FT LAAGYPRLEHITQDTEKTDARSTVGRYDHTDSAALWHKRVHASADPGRPTNVHLRVHGW FT PNQQFALLFVDWLAANPGAREDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEW FT ADAVHWRP" FT CDS complement(207753..208196) FT /transl_table=11 FT /gene="Mb1658c" FT /locus_tag="Mb1658c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1658c, -, len: 147 aa. Equivalent to Rv1632c, len: FT 147 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 147 aa overlap). Hypothetical unknown protein." FT /db_xref="InterPro:IPR014465" FT /db_xref="UniProtKB/TrEMBL:Q7TZV1" FT /protein_id="CAD96326.1" FT /translation="MRAVDEYTVHPWGLYLARPTPGRAQFHYLESWLLPSLGLRATVFH FT FNPSHKRDHDYYLDVGEYTPGPSVWRSEDHYLDIEVRTGGGAELADVDELLDAVRHGLL FT TPTVAEQAVRHAVDAVEGLARNGYDLTRWLATKGMELTWRSGS" FT CDS 208441..210537 FT /transl_table=11 FT /gene="uvrB" FT /locus_tag="Mb1659" FT /product="Excinuclease ABC subunit B uvrB" FT /note="Mb1659, uvrB, len: 698 aa. Equivalent to Rv1633, FT len: 698 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 698 aa overlap). uvrB, Excinuclease abc FT subunit B, has ATP/GTP-binding site motif A (P-loop; FT PS00017) near N-terminus. FASTA best: UVRB_MICLU|P10125 FT from Micrococcus luteus (709 aa), opt: 3268, E(): 0, (71.3% FT identity in 704 aa overlap). Also similar to M. FT tuberculosis Rv2973c (recG); and Rv1020 (mfd). BELONGS TO FT THE UVRB FAMILY." FT /db_xref="GOA:P67423" FT /db_xref="HSSP:1D9X" FT /db_xref="InterPro:IPR004807" FT /db_xref="UniProtKB/Swiss-Prot:P67423" FT /protein_id="CAD96327.1" FT /translation="MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGT FT GKSATTAWLIERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYI FT AQTDTYIEKDSSINDDVERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRSVEL FT KVGEEVPRDGLLRLLVDVQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEI FT EALYYLHPLTGEVIRQVDSLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKL FT LEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDE FT SHVTVPQIGGMYEGDISRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGP FT YELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKK FT MAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVS FT LVAILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADKITDSMREAIDETERRRAKQ FT IAYNEANGIDPQPLRKKIADILDQVYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVS FT AGVFEGRDTSAMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKRELRGMDA FT AGLK" FT CDS 210534..211949 FT /transl_table=11 FT /gene="Mb1660" FT /locus_tag="Mb1660" FT /product="Possible drug efflux membrane protein" FT /note="Mb1660, -, len: 471 aa. Equivalent to Rv1634, len: FT 471 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 471 aa overlap). Possible drug efflux FT membrane protein of major facilitator superfamily (MFS), FT similar to many antibiotic resistance (efflux) proteins. FT FASTA best: Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE (GRAE) FT from Streptomyces violaceoruber (557 aa), opt: 415, E(): FT 1.7e-17, (26.7% identity in 446 aa overlap). Relatives in FT Mycobacterium tuberculosis: MTCY369.27c, E(): 4.8e-12; FT MTCY20B11.14c, E(): 2.9e-10." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q7VEV8" FT /protein_id="CAD96328.1" FT /translation="MTETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPS FT TIADIGGSRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSYLMGLAVFGLASLVCAAA FT PSMQILVAGRTLQGIAGGLLAGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGPATG FT GLFAQLGLWRWAFGVMTLLTALMAMLVPVALGAGRVGPGGETPVGSTHKVPVWSLLLMG FT AAALAISVAALPNYLVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKWIYL FT TMSVQMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSARVIGH FT VVAAAPLVMASGLALGAVTQRADAPVGIIALWALALLIIGTGIGIAWPHLTVRAMDSVA FT DPAESSAAAAAINVVQLISGAFGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIA FT SYQATHRDRRLPR" FT CDS complement(211938..213608) FT /transl_table=11 FT /gene="Mb1661c" FT /locus_tag="Mb1661c" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1661c, -, len: 556 aa. Equivalent to Rv1635c, len: FT 556 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 556 aa overlap). Membrane protein equivalent to FT CAC31770.1|AL583921 Mycobacterium leprae membrane protein FT (527 aa), Identities = 332/527 (62%)." FT /db_xref="UniProtKB/TrEMBL:Q7TZV0" FT /protein_id="CAD96329.1" FT /translation="MHASRPGAPPHAGLPSRRTAGDQDHRADPKVTRIMSASTLEQPAA FT AHVDELVARMRGRLLDPLAIAVLAAVISGAWASRPSLWFDEGATISASASRTLPELWSL FT LGHIDAVHGLYYLLMHGWFAIFPPTELWSRLPSCLAIGAAAAGVVVFAKQFSGRTTAVC FT AGAVFAILPRVTWAGIEARSSALSVAAAVWLTVLLVAAVRCNTQRRWLLYALVLMLSIL FT VSINLALLVPAYATMVPLLASGKSRKSPVIWWTVVTAAALGAMTPFILFAHGQVWQVGW FT IAGLNRNIILDVIHRQYFDHSVPFAILAGLIVAAGIAAHLAGARGPGGDTHRLVLVSAA FT WIVVPTAVVLIYSATVEPIYYPRYLILTAPAAAVILAVCVVTIARKPWLIAGVVFLLAA FT AAFPNYFFTQRGPYAKEGWDYSQVADVISAHAKPGDCLLVDNTAGWRPGPIRALLATRP FT AAFRSLIDVERGTYGPKVGTLWDGHVAVWLTTAKIDKCPTLWTIANRDKSLPDHQVGEM FT LSPGTGFGRTPVYRFPSYLGFRIVERWQFHYSQVVKSTR" FT CDS 213817..214257 FT /transl_table=11 FT /gene="TB15.3" FT /locus_tag="Mb1662" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB15.3" FT /note="Mb1662, TB15.3, len: 146 aa. Equivalent to Rv1636, FT len: 146 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 146 aa overlap). TB15.3, conserved FT hypothetical protein (see citations below), similar to FT other hypothetical proteins from diverse organisms e.g. FT Q57951|MJ0531|Y531_METJA from Methanococcus jannaschii (170 FT aa), FASTA scores: opt: 188, E(): 6e-06, (32.2% identity in FT 149 aa overlap); also P42297|YXIE_BACSU hypothetical 15.9 FT kd protein in bglh-wapa intergenic region precursor from FT Bacillus subtilis (148 aa), FASTA scores: opt: 162, E(): FT 0.00025, (30.8% identity in 156 aa overlap). Part of family FT of Mycobacterium tuberculosis hypothetical proteins (but FT lacks C-terminal region) including Rv2005c, Rv2623, FT Rv2026c, Rv1996, etc." FT /db_xref="GOA:Q7TZU9" FT /db_xref="InterPro:IPR006015" FT /db_xref="UniProtKB/TrEMBL:Q7TZU9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96330.1" FT /translation="MSAYKTVVVGTDGSDSSMRAVDRAAQIAGADAKLIIASAYLPQHE FT DARAADILKDESYKVTGTAPIYEILHDAKERAHNAGAKNVEERPIVGAPVDALVNLADE FT EKADLLVVGNVGLSTIAGRLLGSVPANVSRRAKVDVLIVHTT" FT CDS complement(214264..215058) FT /transl_table=11 FT /gene="Mb1663c" FT /locus_tag="Mb1663c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1663c, -, len: 264 aa. Equivalent to Rv1637c, len: FT 264 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 264 aa overlap). Conserved hypothetical FT protein, some similarity to others e.g. P05446|GLO2_RHOBL FT PROBABLE HYDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) (255 FT aa), FASTA scores: opt: 252, E(): 2e-09, (39.0% identity in FT 146 aa overlap). Also similar to Q9Z505|AL035591|SCC54.20 FT putative hydrolase from Streptomyces coelicolor (218 aa), FT FASTA scores: opt: 732, E(): 0, (52.3% identity in 220 aa FT overlap). Also similar to Mycobacterium tuberculosis FT hypothetical proteins and putative glyoxylases e.g. FT Rv0634c, Rv3677c, Rv2581c, Rv2260." FT /db_xref="GOA:Q7TZU8" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:Q7TZU8" FT /protein_id="CAD96331.1" FT /translation="MLCARTDNHQGTGNVVTSAHMTRANDDDAGAAGIGAVAHMTTVDD FT NYTGHVERGKAARRFLPGATILKASVGPMDNNAYLVTCSATGETLLIDAANDAEVLIDL FT VRRYAPKLALIVTSHQHFDHWQALQAVAAATGAPTAAHPIDADPLPVKPDRLLTHGDSV FT RIGELTFDVIHLRGHTPGSIALALGGPVTGGVTQLFTGDCLFPGGVGKTWQPADFTQLL FT DDVTTRVFDVYADSTVIYPGHGDDTELGAERPSLSEWRARGW" FT CDS 215107..218025 FT /transl_table=11 FT /gene="uvrA" FT /locus_tag="Mb1664" FT /product="Excinuclease ABC, subunit a uvrA" FT /note="Mb1664, uvrA, len: 972 aa. Equivalent to Rv1638, FT len: 972 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 972 aa overlap). uvrA, Excinuclease ABC FT subunit A, similar to many e.g. UVRA_ECOLI|P07671 FT excinuclease abc subunit a from Escherichia coli (940 aa), FT FASTA scores: opt: 2573, E(): 0, (56.2% identity in 951 aa FT overlap). Contains 2x PS00017 ATP/GTP-binding site motif A, FT PS00211 ABC transporters family signature, PS00211 ABC FT transporters family signature. CONSISTS OF THREE SUBUNITS; FT UVRA, UVRB AND UVRC. BELONGS TO THE ABC TRANSPORTER FAMILY. FT UVRA SUBFAMILY." FT /db_xref="GOA:P63381" FT /db_xref="InterPro:IPR004602" FT /db_xref="UniProtKB/Swiss-Prot:P63381" FT /protein_id="CAD96332.1" FT /translation="MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDT FT IFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITE FT VYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQVLAMPEGTRFLVLAPVVRTRKGEF FT ADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHDIEVVVDRLTVKAAAKRRLTDSV FT ETALNLADGIVVLEFVDHELGAPHREQRFSEKLACPNGHALAVDDLEPRSFSFNSPYGA FT CPECSGLGIRKEVDPELVVPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVD FT TPWRKLPAKARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQM FT KERYEGFMRDVPCPVCAGTRLKPEILAVTLAGESKGEHGAKSIAEVCELSIADCADFLN FT ALTLGPREQAIAGQVLKEIRSRLGFLLDVGLEYLSLSRAAATLSGGEAQRIRLATQIGS FT GLVGVLYVLDEPSIGLHQRDNRRLIETLTRLRDLGNTLIVVEHDEDTIEHADWIVDIGP FT GAGEHGGRIVHSGPYDELLRNKDSITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREH FT NLRGIDVSFPLGVLTSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLDY FT LDKLVRVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRC FT EACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTVSEVLDMSIEEAAEF FT FEPIAGVHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTVYILDE FT PTTGLHFDDIRKLLNVINGLVDKGNTVIVIEHNLDVIKTSDWIIDLGPEGGAGGGTVVA FT QGTPEDVAAVPASYTGKFLAEVVGGGASAATSRSNRRRNVSA" FT CDS complement(218082..218339) FT /transl_table=11 FT /gene="Mb1665c" FT /locus_tag="Mb1665c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1665c, -, len: 85 aa. Equivalent to Rv1638A, len: FT 85 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 85 aa overlap). Conserved hypothetical protein, FT similar to C-terminal part of P31511|35KD_MYCTU 35kd FT immunogenic protein from Mycobacterium tuberculosis (270 FT aa), FASTA scores: opt: 159, E(): 0.002, (50.90% identity FT in 55 aa overlap); and to Mycobacterium leprae ML0981 FT possible pseudogene, an orthologue of 35kd immunogenic FT protein from M. tuberculosis. Size difference suggests FT possible gene fragment." FT /db_xref="UniProtKB/TrEMBL:Q7TVB8" FT /protein_id="CAD96333.1" FT /translation="MPDEPTPPEATTPNSESDPRYDSAGVPTFESVREKIETRYGTALG FT ATELDAESPQGRRLEDQYAQRQRAAAERLAQIRESMHTDE" FT CDS complement(218355..219824) FT /transl_table=11 FT /gene="Mb1666c" FT /locus_tag="Mb1666c" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1666c, -, len: 489 aa. Equivalent to Rv1639c, len: FT 489 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 489 aa overlap). Conserved hypothetical FT membrane protein. Some similarity to P35866|YLI2_CORGL FT Hypothetical 45.7 kd protein from Corynebacterium FT glutamicum (426 aa), FASTA scores: opt: 511, E( ): 2.4e-23, FT (28.9% identity in 370 aa overlap). Contains PS00904 FT protein phenyltransferases alpha subunit repeat signature." FT /db_xref="InterPro:IPR000801" FT /db_xref="UniProtKB/TrEMBL:Q7TZU7" FT /protein_id="CAD96334.1" FT /translation="MAQNELVTASTPPAATQPLAVGHTSLMHGWVPLAVQVVTAVVLVL FT AAGWRSRHWQRRWLPTAAAIGATLAWGTRWYVTGNGLANERPPSTLWIWVALTGAAATV FT LILGWRSARWWRRGASLLAVPLCLLSATLTLNLWVGYFPTVQTAWNQLTSGPLPDQADQ FT AAVAALAHSGVRPSHGTLLPVVIPSDASHFKHRGELVYLPPAWFDREHRSENPPPPQLP FT TVMMIGGQFNTPADWARAGNAVKTLDDFAAAHSGNAPVVVFVDSGGAFNNDTECVNGRR FT GNAADHLTKDVVPYMVSKFGVSPEQTSWGIVGWSMGGTCAVDLTVMHPTLFSAFVDIAG FT DFYPNAGNKTQTIVRLFGGNEDAWSAFDPTTVITRHGSYTGLSGWFAISSPGPPSPDNA FT VADTTTMRLAGRDAAANPGNQAAAANALCALGRANGIYCAVVPQPGKHDWPFADRVFAA FT ALPWLAGQLATPGVPKIPLPGTTQQIAGTGR" FT CDS complement(219883..223401) FT /transl_table=11 FT /gene="lysX" FT /locus_tag="Mb1667c" FT /product="Possible lysyl-tRNA synthetase 2 lysX" FT /EC_number="6.1.1.6" FT /note="Mb1667c, lysX, len: 1172 aa. Equivalent to Rv1640c, FT len: 1172 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1172 aa overlap). Probable two domain FT protein, possible lysyl-tRNA synthetase 2 (EC 6.1.1.6). FT N-terminal part (bases 1850153 to 1852033) is similar to FT AL023861|SC3C8_3 hypothetical membrane protein from FT Streptomyces coelicolor (589 aa), Fasta scores: opt: 1426, FT E(): 0, (44.6% identity in 585 aa overlap). The C-terminal FT part is similar to SYK_CRILO|P37879 lysyl-tRNA synthetases FT (EC 6.1.1.6) from Cricetulus longicaudatus (Long-tailed FT hamster) (597 aa), Fasta scores, opt: 985, E(): 0, (36.8% FT identity in 524 aa overlap ). Contains PS00179 FT Aminoacyl-transfer RNA synthetases class-II signature 1, FT PS00339 Aminoacyl-transfer RNA synthetases class-II FT signature 2. This may indicate a frame shift but sequence FT has been checked and no error found. BELONGS TO CLASS-II FT AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:Q7VEV7" FT /db_xref="HSSP:1BBW" FT /db_xref="InterPro:IPR004365" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEV7" FT /protein_id="CAD96335.1" FT /translation="MGLHLTVPGLRRDGRGVQSNSHDTSSKTTADISRCPQHTDAGLQR FT AATPGISRLLGISSRSVTLTKPRSATRGNSRYHWVPAAAGWTVGVIATLSLLASVSPLI FT RWIIKVPREFINDYLFNFPDTNFAWSFVLALLAAALTARKRIAWLVLLANMVLAAVVNA FT AEIAAGGNTAAESFGENLGFAVHVVAIVVLVLGYREFWAKVRRGALFRAAAVWLAGAVV FT GIVASWGLVELFPGSLAPDERLGYAANRVVGFALADPDLFTGRPHVFLNAIFGLFGAFA FT LIGAAIVLFLSQRADNALTGEDESAIRGLLDLYGKDDSLGYFATRRDKSVVFASSGRAC FT ITYRVEVGVCLASGDPVGDHRAWPQAVDAWLRLCQTYGWAPGVMGASSQGAQTYREAGL FT TALELGDEAILRPADFKLSGPEMRGVRQAVTRARRAGLTVRIRRHRDIAEDEMAQTITR FT ADSWRDTETERGFSMALGRLGDPADSDCLLVEAIDPHNQVLAMLSLVPWGTTGVSLDLM FT RRSPQSPNGTIELMVSELALHAESLGITRISLNFAVFRAAFEQGAQLGAGPVARLWRGL FT LVFFSRWWQLETLYRSNMKYQPEWVPRYACYEDARVIPRVGVASVIAEGFLVLPFSRRN FT RVHTGHHPAVPERLAATGLLHHDGSAPDVSGLRQVGLTNGDGVERRLPEQVRVRFDKLE FT KLRSSGIDAFPVGRPPSHTVAQALAADHQASVSVSGRIMRIRNYGGVLFAQLRDWSGEM FT QVLLDNSRLDQGCAADFNAATDLGDLVEMTGHMGASKTGTPSLIVSGWRLIGKCLRPLP FT NKWKGLLDPEARVRTRYLDLAVNAESRALITARSSVLRAVRETLFAKGFVEVETPILQQ FT LHGGATARPFVTHINTYSMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHN FT PEFTLLEAYQAHAGYLEWIDGCRELIQNAAQAANGAPIAMRPRTDKGSDGTRHHLEPVD FT ISGIWPVRTVHDAISEALGERIDADTGLTTLRKLCDAAGVPYRTQWDAGAVVLELYEHL FT VECRTEQPTFYIDFPTSVSPLTRPHRSKRGVAERWDLVAWGIELGTAYSELTDPVEQRR FT RLQEQSLLAAGGDPEAMELDEDFLQAMEYAMPPTGGLGMGIDRVVMLITGRSIRETLPF FT PLAKPH" FT CDS 223638..224243 FT /transl_table=11 FT /gene="infC" FT /locus_tag="Mb1668" FT /product="PROBABLE INITIATION FACTOR IF-3 INFC" FT /note="Mb1668, infC, len: 201 aa. Equivalent to Rv1641, FT len: 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 201 aa overlap). Probable infC, FT initiation factor IF-3, similar to many e.g. FT IF3_BACST|P03000 initiation factor IF-3 from Bacillus FT stearothermophilus (171 aa), FASTA scores: opt: 560, E(): FT 1.9e-27, (50.6% identity in 166 aa overlap). Note that an FT AUC initiation codon has been used, the Bacillus FT (IF3_BACSU) and Escherichia coli (IF3_ECOLI) proteins use FT an AUU initiation codon, and the Myxococcus xanthus FT (DSG_MYXXA) homolog uses a AUC. BELONGS TO THE IF-3 FT FAMILY." FT /db_xref="GOA:P65136" FT /db_xref="HSSP:2IFE" FT /db_xref="InterPro:IPR019815" FT /db_xref="UniProtKB/Swiss-Prot:P65136" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96336.1" FT /translation="MSTETRVNERIRVPEVRLIGPGGEQVGIVRIEDALRVAADADLDL FT VEVAPNARPPVCKIMDYGKYKYEAAQKARESRRNQQQTVVKEQKLRPKIDDHDYETKKG FT HVVRFLEAGSKVKVTIMFRGREQSRPELGYRLLQRLGADVADYGFIETSAKQDGRNMTM FT VLAPHRGAKTRARARHPGEPAGGPPPKPTAGDSKAAPN" FT CDS 224293..224487 FT /transl_table=11 FT /gene="rpmI" FT /locus_tag="Mb1669" FT /product="50S ribosomal protein L35 rpmI" FT /note="Mb1669, rpmI, len: 64 aa. Equivalent to Rv1642, len: FT 64 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 64 aa overlap). rpmI, 50S ribosomal protein FT L35, similar to several e.g. RL35_SYNY3|P48959 from FT Synechocystis sp. (67 aa), fasta scores: opt: 179, E(): FT 2.7e-08, (51.6% identity in 64 aa overlap). BELONGS TO THE FT L35P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66272" FT /db_xref="InterPro:IPR018265" FT /db_xref="UniProtKB/Swiss-Prot:P66272" FT /protein_id="CAD96337.1" FT /translation="MPKAKTHSGASKRFRRTGTGKIVRQKANRRHLLEHKPSTRTRRLD FT GRTVVAANDTKRVTSLLNG" FT CDS 224549..224938 FT /transl_table=11 FT /gene="rplT" FT /locus_tag="Mb1670" FT /product="50S ribosomal protein L20 rplT" FT /note="Mb1670, rplT, len: 129 aa. Equivalent to Rv1643, FT len: 129 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 129 aa overlap). rplT, 50S ribosomal FT protein L20, similar to several e.g. RL20_ECOLI|P02421 from FT Escherichia coli (117 aa), FASTA scores: opt: 438, E(): FT 5.8e-24, (60.3% identity in 116 aa overlap). Contains FT PS00937 Ribosomal protein L20 signature." FT /db_xref="GOA:P66106" FT /db_xref="HSSP:1GYZ" FT /db_xref="InterPro:IPR005812" FT /db_xref="UniProtKB/Swiss-Prot:P66106" FT /protein_id="CAD96338.1" FT /translation="MARVKRAVNAHKKRRSILKASRGYRGQRSRLYRKAKEQQLHSLNY FT AYRDRRARKGEFRKLWIARINAAARLNDITYNRLIQGLKAAGVEVDRKNLADIAISDPA FT AFTALVDVARAALPEDVNAPSGEAA" FT CDS 224971..225753 FT /transl_table=11 FT /gene="tsnR" FT /locus_tag="Mb1671" FT /product="Possible 23S rRNA methyltransferase tsnR" FT /EC_number="2.1.1.-" FT /note="Mb1671, tsnR, len: 260 aa. Equivalent to Rv1644, FT len: 260 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 260 aa overlap). Possible tsnR, 23S rRNA FT methyltransferase (EC 2.1.1.-), similar to several e.g. FT TSNR_STRLU|P52393 from Streptomyces laurentii (270 aa), FT FASTA scores: opt: 276, E(): 3.6e-11, (27.6% identity in FT 261 aa overlap). Also similar to M. tuberculosis FT hypothetical proteins Rv0881, Rv3579c, and Rv0380c." FT /db_xref="GOA:Q7VEV6" FT /db_xref="InterPro:IPR001537" FT /db_xref="UniProtKB/TrEMBL:Q7VEV6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96339.1" FT /translation="MLTERSARVATAVKLHRHVGRRRAGRFLAEGPNLVAAALARGLVR FT EVFVTEVAARRHELLLAAHEASVHLVTERAAKALSDTVTPAGLVAVCDLPATRLEDVLA FT GSPQLIAVTVEIREPGNAGTVIRIADAMGAAAVILAGRSVDPYNGKCLRASTGSIFAIP FT VVVAPDVGAAIADLRAAGLQVLATAVDGEMALDDADRLLAEPTAWLFGPEAHGLSAEIA FT ALADHRVHIPMSGGAESLNVAAAAAICLYESARALGRR" FT CDS complement(225764..226819) FT /transl_table=11 FT /gene="Mb1672c" FT /locus_tag="Mb1672c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1672c, -, len: 351 aa. Equivalent to Rv1645c, len: FT 351 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 351 aa overlap). Conserved hypothetical FT protein, similar to other Mycobacterium tuberculosis FT hypothetical proteins e.g. O53837|Rv0826|MTV043.18 (351 FT aa), FASTA scores: (57.5% identity in 299 aa overlap); FT Q10519|Rv2237|YM37_MYCTU (255 aa), O53682|Rv0276 (306 aa)." FT /db_xref="InterPro:IPR018713" FT /db_xref="UniProtKB/TrEMBL:Q7TZU6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96340.1" FT /translation="MTVASRTSADPLGPDSLTWKYFGDLRTGMMGVWIGAIQNMYPELG FT AGVEEHSILLREPLQRVARSVYPIMGVVYDGDRAAQTGQQIKGYHRTIKGVDAEGRRYH FT ALNPDTFYWAHATFFMLVIKVAEYFCGGLTEAEKHQLFEEHVRWYRMYGMSMRPVPKSW FT EDFQDYWDRVCRDKLEINQATVDILQMRIPKPRFVLMPTPIWDQLFKPLIAGQRWIAAG FT LFDPAVREKAGMHWTPGDEVLLRVFGKVVELAFLAVPDEIRLHPRALAAYRRAAGRTRH FT DAPLVQAPGFMAPPRDRQGLPMHYFPPRSHRFTRSALDPAKALMERAGALVHSTLSLAG FT VRPARGPSRAA" FT CDS 227129..228061 FT /transl_table=11 FT /gene="PE17" FT /locus_tag="Mb1673" FT /product="PE FAMILY PROTEIN" FT /note="Mb1673, PE17, len: 310 aa. Equivalent to Rv1646, FT len: 310 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 310 aa overlap). Member of the M. FT tuberculosis PE family of proteins, similar to many e.g. FT YW36_MYCTU|Q10873 hypothetical 53.7 kd protein cy39.36c FT (558 aa), FASTA scores, opt: 411, E(): 1.3e-15, (34.4% FT identity in 320 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZU5" FT /protein_id="CAD96341.1" FT /translation="MSFLTVAPDMVTAAAGNLESVGSALNEAAAAAAPATVGLAAPAAD FT RVSAVVAAMLGAYARDFQGISAQIAGFHNQFVGALRGGAAAYASAEAANVQQTVVNAVN FT APAQALLGHPLIGPETVGSSAAAVSFGFGPLLLAGSDPLLAVPFSYPASLPTPFGPVTM FT TLNGSFDPLTQQVVFDSGSLTAPAPFVYGLGAVGPALTTMTALQNSGTAFSGAVQSGNL FT LGAAGALLQAPGNAVTGFLFGQTAISQSIPGPSNLGYESVGISVPVGGLLAPLQPVTVT FT LTPTSGMPTAIQLSGTQFGGLLPALLNGF" FT CDS 228139..229089 FT /transl_table=11 FT /gene="Mb1674" FT /locus_tag="Mb1674" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1674, -, len: 316 aa. Equivalent to Rv1647, len: FT 316 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 316 aa overlap). Conserved hypothetical FT protein, some similarity to other Mycobacterium FT tuberculosis hypothetical proteins e.g. FT Q11055|Rv1264|YC64_MYCTU Hypothetical 42.2 kd protein (397 FT aa), FASTA scores: opt: 197, E(): 9.4e-06, (27.1% identity FT in 181 aa overlap) and Q10400|Rv2212|YM12_MYCTU (378 aa)." FT /db_xref="GOA:Q7TZU4" FT /db_xref="InterPro:IPR001054" FT /db_xref="UniProtKB/TrEMBL:Q7TZU4" FT /protein_id="CAD96342.1" FT /translation="MPGSARTTYPCHVEVGPQDSESGAPDETATAMASPVPRQRSALRW FT LRTVNRSPGLVSFIHRARRLLPGDPEFGDPLSTAGEGGPRAAARAADRLLRDRDAASRE FT VGLSVLQVWQALTEAVSRRPANPEVTLVFTDLVGFSTWSLHAGDDATLTLLRQVARAVE FT SPLLDAGGHIVKRLGDGIMAVFRNPTVALRAVLVAQDAVKSLEVQGYTPRMRIGIHTGR FT PQRLAADWLGVDVNIAARVMERATKGGIMISQPTLDLIPQSELDALGVVARRVRKPVFA FT SKPTGIPPDLAIYRIKTVSESTAADNFDEMSPDAQ" FT CDS 229096..229902 FT /transl_table=11 FT /gene="Mb1675" FT /locus_tag="Mb1675" FT /product="Probable transmembrane protein" FT /note="Mb1675, -, len: 268 aa. Equivalent to Rv1648, len: FT 268 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 268 aa overlap). Probable transmembrane FT protein, some similarity to Rv3434c|MTCY77.06C (237 aa), FT FASTA scores: E(): 0.00039, (31.4% identity in 194 aa FT overlap)." FT /db_xref="GOA:Q7VEV5" FT /db_xref="UniProtKB/TrEMBL:Q7VEV5" FT /protein_id="CAD96343.1" FT /translation="MIYRVACLLARIRFTVGYVAALASVSTTILMHGPQVHAQVIRHAS FT TNLHNLAHGHLGTLWNSAFVIDEGPLYFWLPCLACLLAVAELQLRSLRLTVAFVVGHIG FT ATLLVAAVLAGAIEIGWLPWSISRVSDVGMSYGALAALGALTAAIPGRWRPAWIGWWVS FT LGLATATIGGGFTDAGHTVALLLGMLVTACFTRPARWTLGRCALLAVASGFCLVLLAHS FT WWSLVSGSALGLLGALGAAGFARWTRARATSLPPGALAIPQPALSR" FT CDS 230098..231123 FT /transl_table=11 FT /gene="pheS" FT /locus_tag="Mb1676" FT /product="Phenylalanyl-tRNA synthetase, alpha chain pheS" FT /EC_number="6.1.1.20" FT /note="Mb1676, pheS, len: 341 aa. Equivalent to Rv1649, FT len: 341 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 341 aa overlap). pheS, Phenylalanyl-tRNA FT synthetase alpha chain (EC 6.1.1.20), similar to several FT e.g. SYFA_ECOLI|P08312 from Escherichia coli (327 aa), FT FASTA scores: opt: 978, E(): 0, (46.5% identity in 331 aa FT overlap). Homology suggests this start site, but there is a FT potential rbs upstream of a gtg 30 bp upstream; contains FT PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FT FAMILY. PHE-TRNA SYNTHETASE ALPHA CHAIN SUBFAMILY 1." FT /db_xref="GOA:Q7VEV4" FT /db_xref="InterPro:IPR004188" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEV4" FT /protein_id="CAD96344.1" FT /translation="MLSPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALAR FT QALAVLPKEQRAEAGKRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVTLPSTRV FT PAGARHPIIMLAEHVADTFIAMGWELAEGPEVETEQFNFDALNFPADHPARGEQDTFYI FT APEDSRQLLRTHTSPVQIRTLLARELPVYIISIGRTFRTDELDATHTPIFHQVEGLAVD FT RGLSMAHLRGTLDAFARAEFGPSARTRIRPHFFPFTEPSAEVDVWFANKIGGADWVEWG FT GCGMVHPNVLRATGIDPDLYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVG FT A" FT CDS 231123..233618 FT /transl_table=11 FT /gene="pheT" FT /locus_tag="Mb1677" FT /product="Phenylalanyl-tRNA synthetase, beta chain pheT" FT /EC_number="6.1.1.20" FT /note="Mb1677, pheT, len: 831 aa. Equivalent to Rv1650, FT len: 831 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 831 aa overlap). pheT, Phenylalanyl-tRNA FT synthetase beta chain (EC 6.1.1.20), similar to several FT e.g. SYFB_ECOLI|P07395 from Escherichia coli (795 aa), FT FASTA scores: opt: 995, E(): 0, (31.8% identity in 847 aa FT overlap). BELONGS TO THE PHENYLALANYL-TRNA SYNTHETASE BETA FT CHAIN FAMILY - SUBFAMILY 1." FT /db_xref="GOA:Q7VEV3" FT /db_xref="InterPro:IPR002547" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEV3" FT /protein_id="CAD96345.1" FT /translation="MRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGP FT VDGPVTVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDLVVVALPGAT FT LPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPPGAAEPGADGAGVLGLDDV FT VFHLAITPDRGYCMSVRGLARELACAYDLDFVDPASNSRVPPLPIEGPVWPLTVQPETG FT VRRFALRPVIGIDPAAVSPWWLQRRLLLCGIRATCPAVDVTNYVMLELGHPMHAHDRNR FT ISGTLGVRFARSGETAVTLDGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTD FT VLLEAAIWDPAAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLADIAGGEVS FT PTLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQIGAVVTHDGDTLT FT VTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAPAGRGLTAGQQRRRTIGRSLALS FT GYVEILPTPFLPAGVFDLWGLEADDSRRMTTRVLNPLEADRPQLATTLLPALLEALVRN FT VSRGLVDVALFAIAQVVQPTEQTRGVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLA FT GLREPRGPWGPGRPVEAADAFEAVRIIARASRVDVTLRPAQYLPWHPGRCAQVFVGESS FT VGHAGQLHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYPAVFQDVSLVVAAD FT IPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFALRFRAPDRTLTEDDASA FT ARDAAVQSAAERVGAVLRG" FT CDS complement(233712..236768) FT /transl_table=11 FT /gene="PE_PGRS30" FT /locus_tag="Mb1679c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1679c, PE_PGRS30, len: 1018 aa. Equivalent to FT Rv1651c, len: 1011 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.2% identity in 1018 aa overlap). Member FT of the Mycobacterium tuberculosis PE family, PGRS subfamily FT of gly-rich proteins, similar to many e.g. FT Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kd protein FT (603 aa), FASTA scores: opt: 1757, E(): 0, (50.8% identity FT in 714aa overlap). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, an in-frame insertion of 21 bp leads FT to a longer product compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (1018 aa versus FT 1011 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7TZU3" FT /protein_id="CAD96346.1" FT /translation="MSFLLVEPDLVTAAAANLAGIRSALSEAAAAASTPTTALASAGAD FT EVSAAVSRLFGAYGQQFQALNARAATFHAEFVSLLNGGAAAYTGAEAASVSSMQALLDA FT VNAPTQTLLGRPLIGNGADGVAGTGSNAGGNGGPGGILYGNGGNGGAGGPDGGAGGNGG FT AAGLIGNGGAGGAGGVGGAGGAGGAGGTGGLLYGNGGAGGNGGSAAAAGGAGGNALLFG FT NGGNGGSGASGGAAGHAGTIFGNGGNAGAGSGLAGADGGLFGNGGDGGSSTSKAGGAGG FT NALFGNGGDGGSSTVAAGGAGGNTLVGNGGAGGAGGTSGLTGSGVAGGAGGSVGLWGSG FT GAGGDGGAATSLLGVGMNAGAGGAGGNAGLLYGNGGAGGAGGNGGDTTVPLFDSGVGGA FT GGAGGNASLFGNGGTGGVGGKGGTSSDLASATSGAGGAGGAGGVGGLLYGNGGNGGAGG FT IGGAAINILANAGAGGAGGAAGSSFIGNGGNGGAGGAGGAAALFSSGVGGAGGSGGTAL FT LLGSGGAGGNGGTGGANSGSLFASPGGTGGAGGHGGAGGLIWGNGGAGGNGGNGGTTAD FT GALEGGTGGIGGTGGSAIAFGNGGQGGAGGTGGDHSGGNGIGGKGGASGNGGNAGQVFG FT DGGTGGTGGAGGAGSGTKAGGTGSDGGHGGNATLIGNGGDGGAGGAGGAGSPAGAPGNG FT GTGGTGGVLFGQSGSSGPPGAAALAFPSLSSSVPILGPYEDLIANTVANLASIGNTWLA FT DPAPFLQQYLANQFGYGQLTLTALTDATRDFAIGLAGIPPSLQSALQALAAGDVSGAVT FT DVLGAVVKVFVSGVDASDLSNILLLGPVGDLFPILSIPGAMSQNFTNVVMTVTDTTIAF FT SIDTTNLTGVMTFGLPLAMTLNAVGSPITTAIAFAESTTAFVSAVQAGNLQAAAAALVG FT APANVANGFLNGEARLPLALPTSATGGIPVTVEVPVGGILAPLQPFQATAVIPVIGPVT FT VTLEGTPAGGIVPALVNYAPTQLAQAIAP" FT CDS 236962..238020 FT /transl_table=11 FT /gene="argC" FT /locus_tag="Mb1680" FT /product="PROBABLE N-ACETL-GAMMA-GLUTAMYL-PHOSHATE FT REDUCTASE ARGC" FT /EC_number="1.2.1.38" FT /note="Mb1680, argC, len: 352 aa. Equivalent to Rv1652, FT len: 352 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 352 aa overlap). Probable argC, FT N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38), FT similar to many e.g. ARGC_STRCL|P54896 from Streptomyces FT clavuligerus (340 aa) , FASTA scores: opt: 1119, E(): 0, FT (56.9% identity in 350 aa overlap); etc. BELONGS TO THE FT NAGSA DEHYDROGENASE FAMILY." FT /db_xref="GOA:P63563" FT /db_xref="InterPro:IPR012280" FT /db_xref="UniProtKB/Swiss-Prot:P63563" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96347.1" FT /translation="MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGAL FT TAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPET FT LIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYPTAA FT LLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPE FT IAQGLRAVTDRDVSVSFTPVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYL FT MPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMNLALGWP FT ETDGLSVVGVAP" FT CDS 238017..239231 FT /transl_table=11 FT /gene="argJ" FT /locus_tag="Mb1681" FT /product="Probable Glutamate n-acetyltransferase argJ" FT /EC_number="2.3.1.35" FT /note="Mb1681, argJ, len: 404 aa. Equivalent to Rv1653, FT len: 404 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 404 aa overlap). Probable argJ, Glutamate FT n-acetyltransferase (EC 2.3.1.35), similar to FT ARGJ_BACSU|P36843 from Bacillus subtilis (406 aa), fasta FT scores: opt: 727, E(): 0, (36.3% identity in 410 a a FT overlap)." FT /db_xref="GOA:P63572" FT /db_xref="InterPro:IPR002813" FT /db_xref="UniProtKB/Swiss-Prot:P63572" FT /protein_id="CAD96348.1" FT /translation="MTDLAGTTRLLRAQGVTAPAGFRAAGVAAGIKASGALDLALVFNE FT GPDYAAAGVFTRNQVKAAPVLWTQQVLTTGRLRAVILNSGGANACTGPAGFADTHATAE FT AVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKLLAGVAHVVHEMHGGLVGGDEAAHA FT IMTTDNVPKQVALHHHDNWTVGGMAKGAGMLAPSLATMLCVLTTDAAAEPAALERALRR FT AAAATFDRLDIDGSCSTNDTVLLLSSGASEIPPAQADLDEAVLRVCDDLCAQLQADAEG FT VTKRVTVTVTGAATEDDALVAARQIARDSLVKTALFGSDPNWGRVLAAVGMAPITLDPD FT RISVSFNGAAVCVHGVGAPGAREVDLSDADIDITVDLGVGDGQARIRTTDLSHAYVEEN FT SAYSS" FT CDS 239228..240112 FT /transl_table=11 FT /gene="argB" FT /locus_tag="Mb1682" FT /product="Probable Acetylglutamate kinase argB" FT /EC_number="2.7.2.8" FT /note="Mb1682, argB, len: 294 aa. Equivalent to Rv1654, FT len: 294 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 294 aa overlap). Probable argB, FT Acetylglutamate kinase (EC 2.7.2.8), similar to FT ARGB_CORGL|Q59281 (294 aa), FASTA scores: opt: 1209, E(): FT 0, (64.4% identity in 270 aa overlap). BELONGS TO THE FT ACETYLGLUTAMATE KINASE FAMILY." FT /db_xref="GOA:P0A4Y7" FT /db_xref="InterPro:IPR004662" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Y7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96349.1" FT /translation="MSRIEALPTHIKAQVLAEALPWLKQLHGKVVVVKYGGNAMTDDTL FT RRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIEGDFKGGFRVTTPEVLDVARMV FT LFGQVGRELVNLINAHGPYAVGITGEDAQLFTAVRRSVTVDGVATDIGLVGDVDQVNTA FT AMLDLVAAGRIPVVSTLAPDADGVVHNINADTAAAAVAEALGAEKLLMLTDIDGLYTRW FT PDRDSLVSEIDTGTLAQLLPTLESGMVPKVEACLRAVIGGVPSAHIIDGRVTHCVLVEL FT FTDAGTGTKVVRG" FT CDS 240109..241311 FT /transl_table=11 FT /gene="argD" FT /locus_tag="Mb1683" FT /product="Probable Acetylornithine aminotransferase argD" FT /EC_number="2.6.1.11" FT /note="Mb1683, argD, len: 400 aa. Equivalent to Rv1655, FT len: 400 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 400 aa overlap). Probable argD, FT Acetylornithine aminotransferase (EC 2.6.1.11), similar to FT ARGD_ECOLI|P18335 (406 aa), FASTA scores: opt: 958, E(): 0, FT (38.6% identity in 404 aa overlap), contains PS00600 FT Aminotransferases class-III pyridoxal-phosphate attachment FT site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES." FT /db_xref="GOA:P63569" FT /db_xref="HSSP:1QJ3" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P63569" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96350.1" FT /translation="MTGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGRT FT YIDLLGGIAVNVLGHRHPAVIEAVTRQMSTLGHTSNLYATEPGIALAEELVALLGADQR FT TRVFFCNSGAEANEAAFKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFAPLP FT GDVTHVGYGDVDALAAAVDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRGALLV FT LDEVQTGMGRTGAFFAHQHDGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTPGLHGS FT TFGGNPVCAAAALAVLRVLASDGLVRRAEVLGKSLRHGIEALGHPLIDHVRGRGLLLGI FT ALTAPHAKDAEATARDAGYLVNAAAPDVIRLAPPLIIAEAQLDGFVAALPAILDRAVGA FT P" FT CDS 241308..242231 FT /transl_table=11 FT /gene="argF" FT /locus_tag="Mb1684" FT /product="Probable Ornithine carbamoyltransferase, anabolic FT ArgF" FT /EC_number="2.1.3.3" FT /note="Mb1684, argF, len: 307 aa. Equivalent to Rv1656, FT len: 307 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 307 aa overlap). Probable argF, ornithine FT carbamoyltransferase, anabolic (EC 2.1.3.3) (see citation FT below), almost identical to OTCA_MYCBO|Q02095 ornithine FT carbamoyltransferase, anabolic from Mycobacterium bovis FT (307 aa), FASTA scores: opt: 1980, E(): 0, (99.0% identity FT in 307 aa overlap); contains PS00097 Aspartate and FT ornithine carbamoyltransferases signature. BELONGS TO THE FT ATCASES/OTCASES FAMILY." FT /db_xref="GOA:P0A5M9" FT /db_xref="HSSP:1GQ3" FT /db_xref="InterPro:IPR002292" FT /db_xref="UniProtKB/Swiss-Prot:P0A5M9" FT /protein_id="CAD96351.1" FT /translation="MIRHFLRDDDLSPAEQAEVLELAAELKKDPVSRRPLQGPRGVAVI FT FDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRTFG FT QERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANNMAH FT SLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLV FT TDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGP FT ASAVWDEAENRLHAQKALLVWLLERS" FT CDS 242228..242740 FT /transl_table=11 FT /gene="argR" FT /locus_tag="Mb1685" FT /standard_name="ahrC" FT /product="Probable Arginine repressor argR (AHRC)" FT /note="Mb1685, argR, len: 170 aa. Equivalent to Rv1657, FT len: 170 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 170 aa overlap). Probable argR, Arginine FT repressor (alternate gene name: ahrC). Similar to FT AHRC_BACSU|P17893 arginine hydroximate resistance protein FT from Bacillus subtilis (149 aa), FASTA scores: opt: 283, FT E(): 1.8e-11, (34.5% identity in 142 aa overlap); and FT ARGR_ECOLI|P15282 arginine repressor from Escherichia coli FT ( 156 aa), FASTA scores: opt: 194, E(): 6.4e-06, (30.8% FT identity in 146 aa overlap). BELONGS TO THE ARGR FAMILY." FT /db_xref="GOA:P0A4Y9" FT /db_xref="HSSP:1B4B" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Y9" FT /protein_id="CAD96352.1" FT /translation="MSRAKAAPVAGPEVAANRAGRQARIVAILSSAQVRSQNELAALLA FT AEGIEVTQATLSRDLEELGAVKLRGADGGTGIYVVPEDGSPVRGVSGGTDRMARLLGEL FT LVSTDDSGNLAVLRTPPGAAHYLASAIDRAALPQVVGTIAGDDTILVVAREPTTGAQLA FT GMFENLR" FT CDS 242749..243945 FT /transl_table=11 FT /gene="argG" FT /locus_tag="Mb1686" FT /product="Probable Argininosuccinate synthase argG" FT /EC_number="6.3.4.5" FT /note="Mb1686, argG, len: 398 aa. Equivalent to Rv1658, FT len: 398 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 398 aa overlap). Probable argG, FT Argininosuccinate synthase (EC 6.3.4.5), similar to FT ASSY_STRCL|P50986 argininosuccinate synthase from FT Streptomyces clavuligerus (397 aa), FASTA scores: opt: FT 1873, E(): 0, (67.8% identity in 397 aa overlap); contains FT PS00564 Argininosuccinate synthase signature 1, PS00565 FT Argininosuccinate synthase signature 2. BELONGS TO THE FT ARGININOSUCCINATE SYNTHASE FAMILY." FT /db_xref="GOA:P63643" FT /db_xref="HSSP:1KP2" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:P63643" FT /protein_id="CAD96353.1" FT /translation="MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEHMD FT VIRQRALDCGAVEAVVVDARDEFAEGYCLPTVLNNALYMDRYPLVSAISRPLIVKHLVA FT AAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENA FT IPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDIYAYTEDPTINWGVPDEVIVGF FT ERGVPVSVDGKPVSMLAAIEELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLI FT TAHTELEHVTLERELGRFKRQTDQRWAELVYDGLWYSPLKAALEAFVAKTQEHVSGEVR FT LVLHGGHIAVNGRRSAESLYDFNLATYDEGDSFDQSAARGFVYVHGLSSKLAARRDLR" FT CDS 244025..245437 FT /transl_table=11 FT /gene="argH" FT /locus_tag="Mb1687" FT /product="Probable Argininosuccinate lyase argH" FT /EC_number="4.3.2.1" FT /note="Mb1687, argH, len: 470 aa. Equivalent to Rv1659, FT len: 470 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 470 aa overlap). Probable argH, FT argininosuccinate lyase (EC 4.3.2.1), similar to FT ARLY_ECOLI|P11447 argininosuccinate lyase from Escherichia FT coli (457 aa), FASTA scores: opt: 1091, E(): 0, (42.5% FT identity in 461 aa overlap); contains PS00017 FT ATP/GTP-binding site motif A, PS00163 Fumarate lyases FT signature. BELONGS TO THE LYASE 1 FAMILY. ARGININOSUCCINATE FT LYASE SUBFAMILY." FT /db_xref="GOA:P0A4Z1" FT /db_xref="HSSP:1AOS" FT /db_xref="InterPro:IPR000362" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Z1" FT /protein_id="CAD96354.1" FT /translation="MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAH FT TMVLFRAGLLTEEQRDGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRVGPDL FT GGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAAHPSAIMPGKTHLQ FT SAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAADLG FT FSAAADNSVDATAARDFAAEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWSTG FT SSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQL FT ELLLPAMAGLVASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRA FT AEQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRVAEQLNAIG FT EAAERLRRQLVR" FT CDS 245546..246607 FT /transl_table=11 FT /gene="pks10" FT /locus_tag="Mb1688" FT /product="Possible chalcone synthase pks10" FT /EC_number="2.3.1.74" FT /note="Mb1688, pks10, len: 353 aa. Equivalent to Rv1660, FT len: 353 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 353 aa overlap). Possible pks10, chalcone FT synthase (EC 2.3.1.74), similar to BCSA_BACSU|P54157 FT putative chalcone synthase from B. subtilis (365 aa), FASTA FT scores: opt: 701, E(): 0, (33.1% identity in 362 aa FT overlap). Also similar to M. tuberculosis Rv1665|pks11 FT polyketide synthase (chalcone synthase); and Rv1372|pks18 FT polyketide synthase. Other upstream initiation sites are FT possible but homology suggests this start." FT /db_xref="GOA:Q7VEV2" FT /db_xref="InterPro:IPR016038" FT /db_xref="UniProtKB/TrEMBL:Q7VEV2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD96355.1" FT /translation="MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQLHASA FT KVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDESGLRPEDLDVLITA FT TVTGLAVPSLDARIAGRLGLRADVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGVAALV FT SVELCSLTYPGYKPTLPGLVGSALFADGAAAVVAAGVKRAQDIGADGPDILDSRSHLYP FT DSLRTMGYDVGSAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGP FT KIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKPPPSGSPGLMIAMG FT PGFCSELVLLRWH" FT CDS 246690..253070 FT /transl_table=11 FT /gene="pks7" FT /locus_tag="Mb1689" FT /product="Probable polyketide synthase pks7" FT /note="Mb1689, pks7, len: 2126 aa. Equivalent to Rv1661, FT len: 2126 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 2126 aa overlap). Probable pks7, FT polyketide synthase, similar to many e.g. ERY2_SACER|Q03132 FT erythronolide synthase, modules 3 and 4 (3567 aa), FASTA FT scores: E(): 0, (48.8% identity in 2131 aa overlap); also FT similar to Mycobacterium tuberculosis pks12. Contains FT PS00606 Beta-ketoacyl synthases active site, PS00012 FT Phosphopantetheine attachment site." FT /db_xref="GOA:Q7VEV1" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7VEV1" FT /protein_id="CAD96356.1" FT /translation="MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCR FT YPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVA FT GFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYG FT GQGRVPGDLERYGLRGSTLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRL FT GECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARL FT ADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG FT HGTGTTLGDPIEAQAILATYGQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRH FT GVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEE FT APAVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNT FT RSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGM FT GAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVS FT LAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLWDAAAVVALRSRLLVRLGGAGGMVS FT LACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVD FT YASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQ FT FERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGR FT FWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLV FT GAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDE FT VGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQ FT GVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVF FT ADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGVCLHASGAARVRVR FT LAPVGRGAVPVELADPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGLLEMIWTPVPLEG FT GDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAV FT GPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVR FT RGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVELATGQVRVAVG FT AVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVV FT DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSL FT ARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLA FT GEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSE FT VVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVV FT VTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDV FT ADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHEL FT TEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQA FT SAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAA FT LPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR FT SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRL FT VTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTEDDDIAA FT ATESQLFAILDEELGS" FT CDS 253090..257898 FT /transl_table=11 FT /gene="pks8" FT /locus_tag="Mb1690" FT /product="Probable polyketide synthase pks8" FT /note="Mb1690, pks8, len: 1602 aa. Equivalent to Rv1662, FT len: 1602 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 1602 aa overlap). Probable pks8, FT polyketide synthase, similar to many polyketide synthases FT e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 FT and 4 from Saccharopolyspora erythraea (Streptomyces FT erythraeus) (3567 aa), FASTA scores: opt: 3319, E(): 0, FT (45.8% identity in 1619 aa overlap). Also similar to other FT Mycobacterium tuberculosis probable polyketide synthases FT e.g. pks7 and pks12. Contains PS00606 Beta-ketoacyl FT synthases active site and PS01162 Quinone FT oxidoreductase/zeta-crystallin signature. Note that the FT similarity extends into the downstream ORF Rv1663 FT (MTCY275.02), and this could be accounted for by a FT frameshift, although the sequence has been checked and no FT discrepancy was found." FT /db_xref="GOA:Q7VEV0" FT /db_xref="HSSP:1IYZ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7VEV0" FT /protein_id="CAD96357.1" FT /translation="MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRY FT PGGVDSPETLWELVAQGRDAVSDFPADRGWDVYGLFDPDPDACGKMYTRRGTFLEHAGD FT FDAGFFGIGPSEALAMDPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGG FT QLSGELEGYGLTGSTLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGEC FT DLALAGGVTVMATPAAFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDA FT RRLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGT FT GTMLGDPIEAQALLATYGQDRVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMP FT KTLHVDVPTPHVDWSVGAVSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVV FT ESVVPEVASPTAASAVPWVLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRA FT MFEHRAVVVGADRGALLAGLAALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGA FT QLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQPALFAIEVALAT FT LLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAA FT SEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSL FT LMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFVEGVQ FT LLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSVLGAVATLFTAG FT AQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQ FT PDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVT FT PLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLS FT VWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSG FT FGIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVEL FT ADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVV FT WELESFQDGVGPVYSATHRVLVALQSWLAQERAGGLVVLTQGSVGQDATNLAGAAVWGL FT VRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPD FT TNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAE FT LGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVP FT VVFLTAYCALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLH FT TMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMG FT KTEFGTPRSLPRTILGWPTGLST" FT CDS 257898..259406 FT /transl_table=11 FT /gene="pks17" FT /locus_tag="Mb1691" FT /product="Probable polyketide synthase pks17" FT /note="Mb1691, pks17, len: 502 aa. Equivalent to Rv1663, FT len: 502 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 502 aa overlap). Probable pks17, FT polyketide synthase, similar to other polyketide synthases FT e g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 FT and 4 (3567 aa) from Saccharopolyspora erythraea FT (Streptomyces erythraeus), FASTA scores: opt: 1207, E(): 0, FT (43.9% identity in 531 aa overlap). Also similar to other FT Mycobacterium tuberculosis probable polyketide synthases FT e.g. pks7 and pks1. Note that the similarity extends into FT the upstream ORF Rv1662 (MTCY275.01) and this could be FT accounted for by a frameshift, although the sequence has FT been checked and no discrepancy was found. Contains PS00012 FT Phosphopantetheine attachment site." FT /db_xref="GOA:Q7VEU9" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7VEU9" FT /protein_id="CAD96358.1" FT /translation="MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLS FT QARHVGKVVLTMPDAWAAGTVLITGGTGMAGSAVARHLVSRYGVRQVVLASRAGEHTES FT VAALVDELGSAGARVQVVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGLTPE FT RVDKVLRAKVDGAWNLHELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAY FT RRSRGLAALSVAWGLWEQASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADR FT PVVVAARLDRAALAGAELPALFSQLVAGPIRRIIDGADEVSGSGLASRLHGLTPEQRHR FT ELTELVCSNAAIVLGHSGTEIDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFD FT YPTAAELAEHLDIQLANAPAVTVDQPNPSTRFNEVTRELQALLDQPNWNPDDKTRLIKR FT LQAILTDCTAPPASSGPSTTHDDEDITTATESQLFAILDDELGP" FT CDS 259412..262465 FT /transl_table=11 FT /gene="pks9" FT /locus_tag="Mb1692" FT /product="Probable polyketide synthase pks9" FT /note="Mb1692, pks9, len: 1017 aa. Equivalent to Rv1664, FT len: 1017 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 1017 aa overlap). Probable pks9, FT polyketide synthase, similar to OL56_STRAT|Q07017 FT oleandomycin polyketide synthase, modules 5 and 6 from FT Streptomyces antibioticus (3519 aa), FASTA scores: opt: FT 1767, E(): 0, (41.6% identity in 919 aa overlap). Similar FT to other Mycobacterium tuberculosis probable polyketide FT synthases e.g. pks6, pks8, etc. Contains PS00012 FT Phosphopantetheine attachment site." FT /db_xref="GOA:Q7VEU8" FT /db_xref="InterPro:IPR009081" FT /db_xref="UniProtKB/TrEMBL:Q7VEU8" FT /protein_id="CAD96359.1" FT /translation="MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREATGSIDNVADFD FT ADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLT FT LAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEA FT PLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAA FT LDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHG FT TGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVI FT PPSLNYVGAPIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQS FT PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVST FT RSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGM FT GRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVAL FT AALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAV FT AASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFH FT SVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDG FT VGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFA FT GLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVELVC FT FHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPT FT ASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGR FT TVSDEVIDSLSPEALIGLALDEDENDIR" FT CDS 262612..263673 FT /transl_table=11 FT /gene="pks11" FT /locus_tag="Mb1693" FT /product="Possible chalcone synthase pks11" FT /EC_number="2.3.1.74" FT /note="Mb1693, pks11, len: 353 aa. Equivalent to Rv1665, FT len: 353 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 353 aa overlap). Probable pks11, chalcone FT synthase (EC 2.3.1.74), some similarity to FT BCSA_BACSU|P54157 putative chalcone synthase from Bacillus FT subtilis (365 aa), FASTA scores: opt: 615, E(): 6.2e-32, FT (33.4% identity in 308 aa overlap); and to many plant FT chalcone synthases e.g. CHS_VIGUN|P51089 chalcone synthase FT (EC 2.3.1.74) (388 aa), FASTA scores: opt: 391, E(): FT 7.8e-18, (27.2% identity in 349 aa overlap). Highly similar FT to upstream ORF Rv1660|MTCY06H11.25 pks10 (72.7% identity FT in 308 aa overlap); and Rv1372 pks18." FT /db_xref="GOA:Q7VEU7" FT /db_xref="InterPro:IPR016038" FT /db_xref="UniProtKB/TrEMBL:Q7VEU7" FT /protein_id="CAD96360.1" FT /translation="MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAA FT KVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATA FT TVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLV FT SVELCSLTYPAVKPTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYP FT DSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGP FT KVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEKRPPSGSAGLMLAMG FT PGFCTELVLLRWR" FT CDS complement(263656..264948) FT /transl_table=11 FT /gene="cyp139" FT /locus_tag="Mb1694c" FT /product="Probable cytochrome P450 139 CYP139" FT /EC_number="1.14.-.-" FT /note="Mb1694c, cyp139, len: 430 aa. Equivalent to Rv1666c, FT len: 430 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 430 aa overlap). Probable cyp139, FT cytochrome P450 (EC 1.14.-.-), similar to many e.g. FT U38537|APU38537_7 from Anabaena sp. (459 aa), FASTA scores: FT opt: 516, E(): 1.7e-26, (25.8% identity in 418 aa overlap). FT Contains PS00086 Cytochrome P450 cysteine heme-iron ligand FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P63720" FT /db_xref="HSSP:1JPZ" FT /db_xref="InterPro:IPR002403" FT /db_xref="UniProtKB/Swiss-Prot:P63720" FT /protein_id="CAD96361.1" FT /translation="MRYPLGEALLALYRWRGPLINAGVGGHGYTYLLGAEANRFVFANA FT DAFSWSQTFESLVPVDGPTALIVSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNIDTV FT IDGWQPGQRLDIYQELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTRRPPQVMR FT LQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSEEGTTLSDN FT EIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSAL FT TYLNGVVHETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPT FT EFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPA FT QRTHRIRAANFAALRPWPGLTVEIRKSAPAQ" FT CDS complement(264963..266738) FT /transl_table=11 FT /gene="Mb1695c" FT /locus_tag="Mb1695c" FT /product="MACROLIDE-TRANSPORT ATP-BINDING PROTEIN ABC FT TRANSPORTER" FT /note="Mb1695c, -, len: 591 aa. Equivalent to Rv1668c and FT Rv1667c, len: 372 aa and 217 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100% identity in 347 aa overlap FT and 100% identity in 217 aa overlap). Macrolide-transport FT ATP-binding protein ABC transporter (see citation below), FT similar to many ATP-binding proteins ABC transporter e.g. FT X80735|SEABCT_1|Q54072 Saccharopolyspora erythraea ertX FT gene (481 aa), FASTA scores: opt: 938, E(): 0, (45.6% FT identity in 353 aa overlap); etc. Similarity to other NBD FT components of ABC transporters suggests that Rv1667c and FT Rv1668c should be contiguous. However, sequence has been FT checked and no error found, also same sequence in FT Mycobacterium tuberculosis CSU93 and Mycobacterium bovis. FT Contains PS00211 ABC transporters family signature and two FT times PS00017 ATP/GTP-binding site motif A. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 FT genes with a small overlap between them. In Mycobacterium FT bovis, a 10 bp insertion (*-tcttgccgcg) leads to a single FT product." FT /db_xref="GOA:Q7TZU2" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7TZU2" FT /protein_id="CAD96362.1" FT /translation="MAHLLGAEAVHLAYPTQVVFEAVTLGVNDGARIGIVGRNGDGKSS FT LLGLLTGQLRPDSGRVTRRSGLRVNALSQTDTLDPNRTVGWTLIGDQPEHQWAGNPRIR FT DVVAGLVSDIAWDTPVSTLSGGQRRRVQLASLLVGEWDVIALDEPTNHLDIQGITWLAD FT HLRRRWARNTGGLLVVTHDRWFLDEVATTTWEVHDGIVEPFEGGYAAYVLQRVERDRLT FT AAAEAKRQNLLRKELAWLRRGAPARTCKPKFRIEAANQLIADVPPPRNTVELAKLAAAR FT LGKDVVDLLGVSVSYQPSGGRPVLRDIEWRIGPGERIGIVGANGAGKSTLLGLIAGTVQ FT PGVGRVKRGKTVRLAVLDQHGDDLAPFADDRIADVLGRLRGGYQVEGREVTPTQLLERL FT GFRRDQLSARVDDLSGGQRRRLQLMLTLLSEPNVLLLDEPTNDVDTEMLTATEDLLDSW FT AGTLIVVSHDRYLLERVTDQQYAILDDRLRHLPGGIDEYLQLAARVSAPAPAERPAPPA FT MSGAQRRATEKELAAVDRQLARLADRVAAKHTELAEHDQSDHVGITRLTQQLRVLQDHV FT AAMENRWLELSEMLE" FT CDS 267121..267483 FT /transl_table=11 FT /gene="Mb1696" FT /locus_tag="Mb1696" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1696, -, len: 120 aa. Equivalent to Rv1669, len: FT 120 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 120 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZU1" FT /protein_id="CAD96363.1" FT /translation="MSRRPGYSNGRAGASRQAARGGSAGASSVAFSSQPNCGLTESVLG FT HQVTGICLGTIHLDAMQWPWSSAYRLEPAVATTLIGISAWWANGSVKQYAGDLTDRVAT FT MTVCRRTPAPRVHYRQ" FT CDS 267516..267863 FT /transl_table=11 FT /gene="Mb1697" FT /locus_tag="Mb1697" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1697, -, len: 115 aa. Equivalent to Rv1670, len: FT 115 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 115 aa overlap). Conserved hypothetical FT protein, highly similar to D90908|D90908_87 Hypothetical FT protein of Synechocystis sp. PCC6803 complete (94 aa), FT FASTA scores opt: 378, E(): 3.5e-2, (55.2% identity in 96 FT aa overlap); also shows some similarity to M.tuberculosis FT hypothetical proteins e.g. C-terminal region of FT O53404|Rv1056 (254 aa), and P96817|Rv0140 (126 aa)." FT /db_xref="InterPro:IPR007361" FT /db_xref="UniProtKB/TrEMBL:Q7TZU0" FT /protein_id="CAD96364.1" FT /translation="MIRAVWNGTVLAEAPRTVRVEGNHYFPPESLHREHLIESPTTSIC FT PWKGLAHYYNVVVDGPYGPVNPDAAWYYRRPSPLARRIKNHVAFWHGVTVEGESESRHG FT LARRVVAWLGK" FT CDS 267871..268263 FT /transl_table=11 FT /gene="Mb1698" FT /locus_tag="Mb1698" FT /product="HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1698, -, len: 130 aa. Equivalent to Rv1671, len: FT 130 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 130 aa overlap). Probable membrane protein. FT Weak similarity to mercuric transport proteins." FT /db_xref="UniProtKB/TrEMBL:Q7TZT9" FT /protein_id="CAD96365.1" FT /translation="MPTVGPADHAAGLDRRATPDQLPIWRIGIISGLVGMLCCVGPTIL FT ALVGIISAATAFAWANDLYDNYAWWFRVSGLAVLAILVWWALRHRNRCSVNAIRRLRWR FT LMAVLAIAVGTYGVLSAVTTWFGTFV" FT CDS complement(268272..269603) FT /transl_table=11 FT /gene="Mb1699c" FT /locus_tag="Mb1699c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT FT PROTEIN" FT /note="Mb1699c, -, len: 443 aa. Equivalent to Rv1672c, len: FT 443 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 443 aa overlap). Probable conserved integral FT membrane transport protein, major facilitator superfamily, FT similar to several phthalate transporters or tartrate FT transporters e.g. U25634|AVU25634_2 Agrobacterium vitis FT plasmid pTrAB (433 aa), FASTA scores: opt: 914, E(): 0, FT (37.1% identity in 426 aa overlap); etc." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q7TZT8" FT /protein_id="CAD96366.1" FT /translation="MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVAALAM FT NADLRLSATAYGTAAGVFFLGYVLFQVPANAALARFGAGRTLTAVVLAWGVCSAATALV FT TSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPCAQRARAVATFLLAIPVANTVGLPLS FT GLIVGHVHMAGLPGWRAMFVIEALPALLLAPLLRRLLPDNPQRASWLTPEERAELSARL FT TEDTPAPTGRSSGAGWDLVLFAVVYGGLYFALYALQFFLPQLVASLAHGTATLTAATLA FT ALPYGVAALAMLAWSHRSIDRSGAQAGHITLPTTAAGSAALGAALSPMSPIVTLSWLTI FT AVAGILAAMPAFWSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATGTYHL FT ALLTVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV" FT CDS complement(269696..270628) FT /transl_table=11 FT /gene="Mb1700c" FT /locus_tag="Mb1700c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1700c, -, len: 310 aa. Equivalent to Rv1673c, len: FT 310 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 310 aa overlap). Conserved hypothetical FT protein, shows weak similarity to P44103|YA48_HAEIN FT Hypothetical protein HI10 48 precursor (369 aa), FASTA FT scores: E(): 8.3e-11, (26.1% identity in 330 aa overlap)." FT /db_xref="InterPro:IPR002931" FT /db_xref="UniProtKB/TrEMBL:Q7TZT7" FT /protein_id="CAD96367.1" FT /translation="MTITDPAVSAHADATIGLFEITDHITIDSTQGAHTVEMWCPVIGD FT GAFQRVLDVEVTSEDPYDLTREPEFGNLMLYSRLRLATAASWSIRYVVERRAIGHAPDP FT ARARPLATAQLFSRALIPEAHVDVDERTRTLAQDVVGPETNPLEQARRIYDYVTGAMDY FT DATKQSFLGSTEHALTCSVGNCNDIHALFVSLCRSVDIPARFVLGQALELPQPGAQDCE FT VCGYHCWAEFFVAGLGWLPADASCATKYGTHGLFANLQANHIAWSIGRDILLAPPQRAG FT RSLFFAGPYAEIDGETHPAQRQIRFTAMT" FT CDS complement(270656..271312) FT /transl_table=11 FT /gene="Mb1701c" FT /locus_tag="Mb1701c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1701c, -, len: 218 aa. Equivalent to Rv1674c, len: FT 218 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 218 aa overlap). Probable transcriptional FT regulatory protein. Highly similar to AJ005575|SPE005575_2 FT Streptomyces peucetius (226 aa), FASTA scores: opt: 662, FT E(): 0, (50.0% identity in 208 aa overlap). Similar to FT Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FT FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa FT overlap). N-terminus is similar to transcriptional FT activators e.g. MERR_STRLI|P30346 probable mercury FT resistance operon regulator (125 aa), FASTA scores: opt: FT 183, E(): 1.9e-06, (35.6% identity in 90 aa overlap). FT Contains PS00380 Rhodanese signature 1." FT /db_xref="GOA:Q7TZT6" FT /db_xref="HSSP:1E0C" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:Q7TZT6" FT /protein_id="CAD96368.1" FT /translation="MSGAKKLIFEQFALVGQALSSGHRLELLDLLVQGERSVDALARAS FT GLTFANASQHLLQLRRAGLVTSRRDGKRVIYALSDPQVWDVVRAVRAVAERNLASVGSL FT VRQYYTDRDSLEPISRDELQARVAAGSVLVLDVRPAMEYAAGHLPGAVSIPLDELAERL FT DELPSGIDIVACCRGPYCVYAYDALELLRPNGFSARRLDGGFSEWLAADLPVVRT" FT CDS complement(271637..272371) FT /transl_table=11 FT /gene="Mb1702c" FT /locus_tag="Mb1702c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1702c, -, len: 244 aa. Equivalent to Rv1675c, len: FT 244 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 244 aa overlap). Probable FT transcriptional regulatory protein, weak similarity to FT D00496|LBATRP_7 trp operon from Lactobacillus casei (219 FT aa), FASTA scores: opt: 172, E(): 0.00011, (26.9% identity FT in 186 aa overlap)." FT /db_xref="GOA:Q7TZT5" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:Q7TZT5" FT /protein_id="CAD96369.1" FT /translation="MADRSVRPLRHLVHAVTGGQPPSEAQVRQAAWIARCVGRGGSAPL FT HRDDVSALAETLQAKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAVVNILHP FT GDVDGDIPLLLEMPMVYTGRALTQATCLFLDRQAFERLLATHPAIARRWLSSVAQRVST FT AQIRLMGMLGRPLPAQVAQLLLDEAIDARIELAQRTLAAMLGAQRPSINKILKEFERDR FT LITVGYAVIEITDQHGLRARAQ" FT CDS 272443..273147 FT /transl_table=11 FT /gene="Mb1703" FT /locus_tag="Mb1703" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1703, -, len: 234 aa. Equivalent to Rv1676, len: FT 234 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 234 aa overlap). Hypothetical unknown protein." FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/TrEMBL:Q7TZT4" FT /protein_id="CAD96370.1" FT /translation="MACPEWEISRSKRTRKPVLRPRHSVSTLTNRFLAEFCHRYGIGVP FT TRLARGATVPTRRLQDINDQPVDVPAATGRTHLQFRRFAACPICHLHLRSFANRHQEVA FT DSGITEVVFFHSAADALRGYQSLLPFAVIADPDRVQYREFGVEKSLGAITHPRALWAAV FT RGSAAMLHRNDPERAGVGFGDGTTHLGLPADFLLDADGTVAAVHYGRHADDQWSVDQLI FT DINRSLGGKGTQ" FT CDS 273144..273692 FT /transl_table=11 FT /gene="dsbF" FT /locus_tag="Mb1704" FT /product="PROBABLE CONSERVED LIPOPROTEIN DSBF" FT /note="Mb1704, dsbF, len: 182 aa. Equivalent to Rv1677, FT len: 182 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 182 aa overlap). Probable dsbF, conserved FT lipoprotein possibly involved in thiol:disulfide FT interchange. Highly similar to C-terminus of FT Z74024|MTCY274.09 mpt53 soluble secreted antigen precursor FT from Mycobacterium tuberculosis (173 aa), FASTA scores: FT opt: 482, E(): 3.6e-23, (52.8% identity in 142 aa overlap) FT . Also some similarity to P52237|TIPB_PSEFL THIOL:DISULFIDE FT INTERCHANGE PROTEIN TIPB PRECURSOR from Pseudomonas FT fluorescens (178 aa), FASTA scores: opt: 190, E(): 4.4e-05, FT (28.5% identity in 151 aa overlap); and P33926|DSBE_ECOLI FT THIOL:DISULFIDE INTERCHANGE PROTEIN from Escherichia coli FT (185 aa), FASTA scores: opt: 194, E(): 2.6e-05, (29.1% FT identity in 175 aa overlap). Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site and PS00194 FT Thioredoxin family active site." FT /db_xref="GOA:Q7TZT3" FT /db_xref="HSSP:1LU4" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/TrEMBL:Q7TZT3" FT /protein_id="CAD96371.1" FT /translation="MTHSRLIGALTVVAIIVTACGSQPKSQPAVAPTGDAAAATQVPAG FT QTVPAQLQFSAKTLDGHDFHGESLLGKPAVLWFWAPWCPTCQGEAPVVGQVAASHPEVT FT FVGVAGLDQVPAMQEFVNKYPVKTFTQLADTDGSVWANFGVTQQPAYAFVDPHGNVDVV FT RGRMSQDELTRRVTALTSR" FT CDS 273793..274695 FT /transl_table=11 FT /gene="Mb1705" FT /locus_tag="Mb1705" FT /product="HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN" FT /note="Mb1705, -, len: 300 aa. Equivalent to Rv1678, len: FT 300 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 300 aa overlap). Probable integral membrane FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7TZT2" FT /protein_id="CAD96372.1" FT /translation="MARVRRGTELLLSPQSPPATGGLIVLTGLRLLAGLIWLYNVVWKV FT PPDFGERGRRDLYHFTHLAVEHPVFTPFSWVIEHAVLPYFTAFGWGVLFAESALAVLLL FT TGTAVRLAALIGIGQSVAIGLSVAESPGEWPWAYAMLLGIHVVLLFTCSTRYAAVDAVR FT AAATGSAARTAAQRLLAGWGIVLGLIGLVAVWRGLGDDRPAYVGIRALEFSLGEYNLRG FT ALALIAIALAMLAAAKRGWRTVALVAAVVAVAAAAAIYLQVGRTAVWLGGTNTTAAVFV FT CAAVVSLATEFRIGRVEGA" FT CDS 274695..275816 FT /transl_table=11 FT /gene="fadE16" FT /locus_tag="Mb1706" FT /product="POSSIBLE ACYL-COA DEHYDROGENASE FADE16" FT /EC_number="1.3.99.-" FT /note="Mb1706, fadE16, len: 373 aa. Equivalent to Rv1679, FT len: 373 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 373 aa overlap). Possible fadE16, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to FT acyl/butyryl-CoA dehydrogenases e.g. NP_244665.1|NC_002570 FT acyl-CoA dehydrogenase from Bacillus halodurans (380 aa); FT NP_000008.1|NM_000017 acyl-Coenzyme A dehydrogenase from FT Homo sapiens (412 aa); Z99113|BSUB0010_119 from Bacillus FT subtilis (380 aa), FASTA scores: opt: 439, E(): 3.4e-20, FT (29.6% identity in 287 aa overlap); etc. Weakly similar to FT many dehydrogenases and to P31571|CAIA_ECOLI probable FT carnitine operon oxidoreductase from Escherichia coli (380 FT aa), FASTA scores: opt: 109, E(): 0.0066, (28.6% identity FT in 98 aa overlap)." FT /db_xref="GOA:Q7TZT1" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7TZT1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id=" |