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EBI DbfetchID BX248338; SV 1; linear; genomic DNA; STD; PRO; 299450 BP. XX AC BX248338; XX DT 10-JUN-2003 (Rel. 76, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 5/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-299450 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF01118; PK-G12rRNA. DR SILVA-LSU; BX248338. DR SILVA-SSU; BX248338. XX FH Key Location/Qualifiers FH FT source 1..299450 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS 375..6632 FT /transl_table=11 FT /gene="pks3" FT /locus_tag="Mb1213" FT /product="PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS3" FT /EC_number="2.3.1.-" FT /note="Mb1213, pks3, len: 2085 aa. Equivalent to Rv1180 and FT Rv1181, len: 488 aa and 1582 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100% identity in 488 aa overlap FT and 99.9% identity in 1582 aa overlap). Probable polyketide FT beta-ketoacyl synthase (EC 2.3.1.-), similar to the FT N-terminus of many polyketide synthases e.g. FT MCAS_MYCBO|Q02251 mycocerosic acid synthase from FT mycobacterium bovis (2110 aa), FASTA scores: opt: 2115, FT E(): 0, (66.5% identity in 472 aa overlap). Also similar FT to, and same length as P96284|Z83858|MTCY24G1.02 M. FT tuberculosis (496 aa), FASTA scores: opt: 1424, E(): 0, FT (50.9% identity in 444 aa overlap). Contains possible FT signal sequence and PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site, also PS00606 FT Beta-ketoacyl synthases active site. BELONGS TO THE FT BETA-KETOACYL-ACP SYNTHASES FAMILY. Probable polyketide FT synthase, similar to many e.g. MCAS_MYCBO|Q02251 FT mycocerosic acid synthase from mycobacterium bovis (2110 FT aa), FASTA scores: opt: 3518, E(): 0, (59.7% identity in FT 1614 aa overlap). Note that this similarity extends FT upstream of the first initiation codon into the upstream FT MTV005.16; however the stop codon at the end of MTV005.16 FT is present in at least 4 independent clones (BAC, cosmid FT and pUC) from the genome. The two CDS's may represent FT separate modules of the polyketide synthase. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 FT genes. In Mycobacterium bovis, a single base transversion FT (a-c) leads to a single product (similar to other FT organisms)." FT /db_xref="GOA:Q7U0G2" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U0G2" FT /protein_id="CAD94074.1" FT /translation="MRTATATSVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPAD FT RWDANVYYDPEPGVPGRSVSRWGAFLDDVGGFDCDFFGLTEREATAIDPQHRLLLEVSW FT EAIEHAGVDPATLAESQTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGRVAY FT TLGLHGPAVTVDTACSSGLTAVHQACRSLDDGESDLALAGGVVVTLEPRKSVSGSLQGM FT LSPTGRCHAFDEAADGFVSGEGCVVLLLKRLPDAVRDGDRVLAIVRGTAANQDGRTVNI FT AAPSAQAQIAVYQQALAAAGVEASTVGMVEAHGTGTPVGDPVEYASLAAVYGTEGPCAL FT TSVKTNFGHLQSASGPLGLMKTILALRHGVVPQNLHFCRLPDQLAEIDTELFVPQANTS FT WPDNTGQPRRAAVSSYGMSGTNVHAILEQAPVSEPAASGPELTPEAGGLALFPVSATSA FT EQLHVTAARLADWVDQNGNAGSRVSMRDLGYTLSCRRAHRPVRTVVTASSFDELSAALR FT DVAGDQIPYQPAVGHDDRGPVWVFSGQGSQWPGMGTELLVAEPVFAATVAAMEPVIARE FT SGFSVTEAMSAPQTVSGIDRVQPTIFAVQVALAAALKSYGVRPGAIIGHSLGEAAAAVV FT AGALSLHDGLRVICRRSRLMSRIAGSGAMASVELPGQQVLSELAIRGISDVVLSVVASP FT TSTVVGGATQSIRDLVAAWEQQDVLAREVAVDVASHTPQVDPILDELLEVLAEVDPTAP FT EIPYYSATLWDPRERPSFTGEYWVENLRYTVRFAAAVQAALKDGYRVFGELAPHPLLTY FT AVEQNAASLDMPIATLAAMRRGEQLPFGLRGFVADVHNAGAKVDFSVQYPDGRLVDAPL FT PSWTHRTLMLSREDSHRSHTGAVQAVHPLLGAHVHLLEEPERHVWQAGVGTGAHPWLGD FT HRIHNVAAFPGAAYCEMALAAARTTLGELSEVRDIKFEQTLLLDEQTVVSSAATIAAPG FT ILQFAVESHQEGEPARRASAMLHALEEMPQPPGYDTNALTAAHESSMSGEELRKMFNSL FT GIQYGPAFSGLVAVHTARGAVTTVLAEVALPGAIRSQQSAYASHPALLDACFQSVLVHP FT EVQKATVGGLMLPVGVRRLRNYHSTRSAHYCLARVTSSSRAGECEADLDVFDQAGTVLL FT TVEGLRLAAGISEHERANRVFDERLLTIEWERGELPEVPQIDAGSWLLLSASEADPLTA FT QLADALNAVGAQSTSVASASDVAQLRSLLGGRLTGVVVVTGPPTGGLTQCGRDYVSQLV FT GIARELAELPGEPPRLFVVTRSAASVLPSDLANLEQAGLRGLMRVIDSEHPHLGATAID FT VDNDETVAALVASQLQSGSQEDETAWRNGIWYTARLRPGPLRPAERRTAVVEYRRDGMR FT LQIRTPGDLESLEFVTFDRVAPGPGEIEVAVTASSVNFADVLVAFGRYPTFEGYRQQLG FT IDFAGVVTAVGPDVTEHRIGDHVGGMSANGCWSTFVRCDARLAVTLPPELPVAAAAAVP FT TASATAWYALHDLARICSDDKVLIHSGTGGVGQAAIAIARAAGCEIFATAGSAQRRQLL FT HDMGVEHVYDSRSTEFAEQIRGDTDGYGVDVVLNSLPGAAQRAGIELLAFGGRFVEIGK FT RDIYGDTRLGLFPFRRNLSLYAVDLALLTHSHPHTVRRLLKTVYQHTVEGTLPVPQTTH FT YPIHDAAVAIRLVGGAGHTGKVVLDVPRTGEGVAVVPPEQVRTSRPDGAYLVTGGLGGL FT GLFLAGELAAAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGDIADAATAHRVV FT AVATASGLPVRGVLHAAAVVEDATLANVTDELIDRCWAPKVHGAWNIHRATAAQPLEWF FT CLFSSAAALVGSPGQGAYAAANSWLDAFAHWRRAQGLPATSIAWGAWAEIGRATALAEG FT TGAAIAPAEGARAFQTLLRYGRAYSGYAPIMGTPWLTAFAQRSRFAEAFHATGQNQPAT FT GKFLAELGSLPREEWPRTVRRLVSDQISLLLRRTIDPDRPLSDYGLDSLGNLELRTRIE FT TETGIRVSPTKITTVRGLAEHVCDELAAAQSAPV" FT CDS 6685..8103 FT /transl_table=11 FT /gene="papA3" FT /locus_tag="Mb1214" FT /product="PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED FT PROTEIN PAPA3" FT /note="Mb1214, papA3, len: 472 aa. Equivalent to Rv1182, FT len: 472 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 472 aa overlap). Probable papA3, FT conserved polyketide synthase (PKS) associated protein, FT similar to other Mycobacterial hypothetical proteins e.g. FT Q49618|U00010 B1170_C1_180 from Mycobacterium leprae (471 FT aa), FASTA scores: opt: 2526, E(): 0, (75.6% identity in FT 471 aa overlap). Similar to other Mycobacterium FT tuberculosis hypothetical papA proteins; Rv3824c, Rv3820c, FT Rv1528c." FT /db_xref="InterPro:IPR001242" FT /db_xref="UniProtKB/TrEMBL:Q7U0G1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94075.1" FT /translation="MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPV FT SYMQAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDTYRSWFQ FT YNGNGQIIRRTIQDPADIEFVPVHHGELTLPQIREIVQNTPDPLQWGCFRFGIVQGCDH FT FTFFASVDHVHVDAMIVGVTLMEFHLMYAALVGGHAPLELPPAGSYDDFCRRQHTFSST FT LTVESPQVRAWTKFAEGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCT FT AAGARFIGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIA FT GSAFGDAARAAQTSFDSGVKLAEVPYDRVVELSSTLTMPRPNFPVVNFLDAGAAPLSVL FT LTAELTGTNIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFPDNPIARESVARYLATLKSV FT FQRVAESGQQQNVA" FT CDS 8170..11178 FT /transl_table=11 FT /gene="mmpL10" FT /locus_tag="Mb1215" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL10" FT /note="Mb1215, mmpL10, len: 1002 aa. Equivalent to Rv1183, FT len: 1002 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 1002 aa overlap). Probable mmpL10, FT conserved transmembrane transport protein (see first FT citation below), member of RND superfamily, similar to many FT Mycobacterial hypothetical membrane proteins e.g. FT Q49619|U00010 from Mycobacterium leprae (1008 aa), FASTA FT scores: opt: 4545, E(): 0, (70.6% identity in 978 aa FT overlap); etc. BELONGS TO THE MMPL FAMILY." FT /db_xref="GOA:P65373" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/Swiss-Prot:P65373" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94076.1" FT /translation="MVGCWVALALVLPMAVPSLAEMAQRHPVAVLPADAPSSVAVRQMA FT EAFHESGSENILVVLLTDEKGLGAADENVYHTLVDRLRNDAKDVVMLQDFLTTPPLREV FT LGSKDGKAWILPIGLAGDLGTPKSYHAYTDVERIVKRTVAGTTLTANVTGPAATVADLT FT DAGARDRASIELAIAVMLLVILMVIYRNPVTMLLPLVTIGASLMTAQALVAGVSLVGGL FT AVSNQAIVLLSAMIAGAGTDYAVFLISRYHEYVRLGEHPERAVQRAMMSVGKVIAASAA FT TVGITFLGMRFAKLGVFSTVGPALAIGIAVSFLAAVTLLPAILVLASPRGWVAPRGERM FT ATFWRRAGTRIVRRPKAYLGASLIGLVALASCASLAHFNYDDRKQLPPSDPSSVGYAAM FT EHHFSVNQTIPEYLIIHSAHDLRTPRGLADLEQLAQRVSQIPGVAMVRGVTRPNGETLE FT QARATYQAGQVGNRLGGASRMIDERTGDLNRLASGANLLADNLGDVRGQVSRAVAGVRS FT LVDALAYIQNQFGGNKTFNEIDNAARLVSNIHALGDALQVNFDGIANSFDWLDSVVAAL FT DTSPVCDSNPMCGNARVQFHKLQTARDNGTLDKVVGLARQLQSTRSPQTVSAVVNDLGR FT SLNSVVRSLKSLGLDNPDAARARLISMQNGANDLASAGRQVADGVQMLVDQTKNMGIGL FT NQASAFLMAMGNDASQPSMAGFNVPPQVLKSEEFKKVAQAFISPDGHTVRYFIQTDLNP FT FSTAAMDQVNTIIDTAKGAQPNTSLADASISMSGYPVMLRDIRDYYERDMRLIVAVTVV FT VVILILMALLRAIVAPLYLVGSVVISYMSAIGLGVVVFQVFLGQELHWSVPGLAFVVLV FT AVGADYNMLLASRLRDESALGVRSSVIRTVRCTGGVITAAGLIFAASMSGLLFSSIGTV FT VQGGFIIGVGILIDTFVVRTITVPAMATLLGRASWWPGHPWQRCAPEEGQMSARMSART FT KTVFQAVADGSKR" FT CDS complement(11182..12261) FT /transl_table=11 FT /gene="Mb1216c" FT /locus_tag="Mb1216c" FT /product="POSSIBLE EXPORTED PROTEIN" FT /note="Mb1216c, -, len: 359 aa. Equivalent to Rv1184c, len: FT 359 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 359 aa overlap). Possible exported protein with FT potential N-terminal signal sequence. Similar to several FT Mycobacterial hypothetical proteins e.g. Q49633|U00010) FT Protein B1170_F3_112 from M. leprae (391 aa), FASTA scores: FT opt: 1422, E(): 0, (62.7% identity in 338 aa overlap). Also FT similar to Rv3822, Rv3539, Rv1430, Rv0151c, etc." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/TrEMBL:Q7U0G0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94077.1" FT /translation="MKRVIAGAFAVWLVGWAGGFGTAIAASEPAYPWAPGPPPSPSPVG FT DASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAGAAFSWWPTMLLPP FT GSHQDNMTVGVAVKDGTNSLDNAIHHGTDPAAAVGLSQGSLVLDQEQARLANDPTAPAP FT DKLQFTTFGDPTGRHAFGASFLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYD FT GFSDFPDRPDNLLAVANAAIGAAIAHTPIGFTGPGDVPPQNIRTTVNSRGATTTTYLVP FT VNHLPLTLPLRYLGMSDAEVDQIDSVLQPQIDAAYARNDNWFTRPVSVDPVRGLDPLTA FT PGSIVEGARGLLGSPAFGG" FT CDS complement(12426..14162) FT /transl_table=11 FT /gene="fadD21" FT /locus_tag="Mb1217c" FT /product="PROBABLE FATTY-ACID--COA LIGASE FADD21 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1217c, fadD21, len: 578 aa. Equivalent to Rv1185c, FT len: 578 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 578 aa overlap). Probable fadD21, FT fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to FT several from Mycobacteria e.g. NP_301895.1|NC_002677 FT possible acyl-CoA synthase from Mycobacterium leprae (579 FT aa); P71495|U75685 ACYL-COA SYNTHASE from Mycobacterium FT bovis (582 aa), FASTA scores: opt: 2388, E(): 0, (61.8% FT identity in 579 aa overlap); etc. SEEMS TO BELONG TO THE FT ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:P63524" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/Swiss-Prot:P63524" FT /protein_id="CAD94078.1" FT /translation="MSDSSVLSLLRERAGLQPDDAAFTYIDYEQDWAGITETLTWSEVF FT RRTRIVAHEVRRHCTTGDRAVILAPQGLAYIAAFLGSMQAGAIAVPLSVPQIGSHDERV FT SAVLADASPSVILTTSAVAEAVAEHIHRPNTNNVGPIIEIDSLDLTGNSPSFRVKDLPS FT AAYLQYTSGSTRAPAGVMISHRNLQANFQQLMSNYFGDRNGVAPPDTTIVSWLPFYHDM FT GLVLGIIAPILGGYRSELTSPLAFLQRPARWLHSLANGSPSWSAAPNFAFELAVRKTTD FT ADIEGLDLGNVLGITSGAERVHPNTLSRFCNRFAPYNFREDMIRPSYGLAEATLYVASR FT NSGDKPEVVYFEPDKLSTGSANRCEPKTGTPLLSYGMPTSPTVRIVDPDTCIECPAGTI FT GEIWVKGDNVAEGYWNKPDETRHTFGAMLVHPSAGTPDGSWLRTGDLGFLSEDEMFIVG FT RMKDMLIVYGRNHYPEDIESTVQEITGGRVAAISVPVDHTEKLVTVIELKLLGDSAGEA FT MDELDVIKNNVTAAISRSHGLNVADLVLVPPGSIPTTTSGKIRRAACVEQYRLQQFTRL FT DG" FT CDS complement(14339..15955) FT /transl_table=11 FT /gene="Mb1218c" FT /locus_tag="Mb1218c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1218c, -, len: 538 aa. Equivalent to Rv1186c, len: FT 538 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 538 aa overlap). Conserved hypothetical FT protein, similar to AL117385|SC5G9.24 hypothetical protein FT from Streptomyces coelicolor (555 aa), FASTA scores: opt: FT 485, E(): 2.3e-23, (32.6% identity in 568 aa overlap). FT Contains helix turn helix motif from aa 488-509 (+2.81 FT SD)." FT /db_xref="UniProtKB/TrEMBL:Q7U0F9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94079.1" FT /translation="MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSDDVR FT LGLAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPSDSVVAGAVRAGSAV FT VAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLAQSLADRIHGMISIEDAQS FT HVLAYSASNDEADELRRLSILGRAGPPEHLQWIGQWGIFDALRAGREVVRVAERPELGL FT RPRLAIGIHQPGVGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQ FT PNTHALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAVRHV FT RLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTISALRAELGVALR FT AAIAGPVAGLAEVNPARVEVDRVLESAERHPILGQVTSLAEARTTVLLDEIVTLVGTDQ FT RLVDPRIRDLGAQDPVLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTS FT LGDPDVRLLFSLGLRAMERTA" FT CDS 16040..17671 FT /transl_table=11 FT /gene="rocA" FT /locus_tag="Mb1219" FT /product="PROBABLE PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FT ROCA" FT /EC_number="1.5.1.12" FT /note="Mb1219, rocA, len: 543 aa. Equivalent to Rv1187, FT len: 543 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 543 aa overlap). Probable rocA, FT pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12), FT similar to many e.g. PUT2_HUMAN|P30038 human FT delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa), FT FASTA scores: opt: 1596, E():0, (46.0% identity in 531 aa FT overlap). Also similar to other Mycobacterium tuberculosis FT hypothetical dehydrogenases e.g. Rv0768, Rv2858c, etc. FT Contains PS00687 Aldehyde dehydrogenases glutamic acid FT active site and PS00070 Aldehyde dehydrogenases cysteine FT active site." FT /db_xref="GOA:Q7U0F8" FT /db_xref="InterPro:IPR016162" FT /db_xref="UniProtKB/TrEMBL:Q7U0F8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94080.1" FT /translation="MDAITQVPVPANEPVHDYAPKSPERTRLRTELASLADHPIDLPHV FT IGGRHRMGDGERIDVVQPHRHAARLGTLTNATHADAAAAVEAAMSAKSDWAALPFDERA FT AVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFWRFNVAFARQILEQQ FT PISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPALMGNTVIWKPSITQTLAAY FT LTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQWVGTNI FT GRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAFIAHSVW FT QRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVTVAVGGEY FT DDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTG FT AVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTNDKAGSPLNLL FT RWTSARSIKETFVAATDHIYPHMAVD" FT CDS 17671..18660 FT /transl_table=11 FT /gene="Mb1220" FT /locus_tag="Mb1220" FT /product="PROBABLE PROLINE DEHYDROGENASE" FT /EC_number="1.5.99.8" FT /note="Mb1220, -, len: 329 aa. Equivalent to Rv1188, len: FT 329 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 329 aa overlap). Possible putA, proline FT dehydrogenase (EC 1.5.99.8), similar to part of FT Q52711|X78346 proline dehydrogenase from Rhodobacter FT capsulatus (1127 aa), FASTA scores: opt: 194, E(): 1.5e-07, FT (31.2% identity in 349 aa overlap). Also similar to two FT Bacillus subtilis proline dehydrohenases E1184363|Z99120 FT (302 aa), FASTA scores: opt: 509, E(): 0, (37.1% identity FT in 313 aa overlap); and E1182272|Z99105 (303 aa), FASTA FT scores: opt: 513, E(): 0, (32.5% identity in 311 aa FT overlap). Highly similar to AL035569|SC8D9.31 Streptomyces FT coelicolor (308 aa), FASTA scores: opt: 984, E(): 0, (50.0% FT identity in 312 aa overlap)." FT /db_xref="GOA:Q7U0F7" FT /db_xref="InterPro:IPR015590" FT /db_xref="UniProtKB/TrEMBL:Q7U0F7" FT /protein_id="CAD94081.1" FT /translation="MAGWFAHTLRPAMLAAGRSDRLGRIVERSPLTRGVVRRFVPGDTL FT DDVVDIVTALRDSGRYLSIDYLGENVTDADDAAAAVRAYLGLLDVLGRRGDIACDGVRP FT LEVSLKLSALGQALDRDGQKIALDNARAICERAERVGAWVTVDAEDHTTTDSTLSISGD FT LRVDFPWLGTVVQAYLRRTLADCAELAAVGARVRLCKGAYDEPASVAYRDAAQVTDSYL FT RCLRVLTAGRGYPMVATHDPVIIAAVPGITRESGRSQGDFEYQMLYGVRDDEQRRLTGA FT GNHVRVYVPFGTRWYGYFLRRLAERPANLAFFLRALTDRRRARGCAER" FT CDS 18742..19614 FT /transl_table=11 FT /gene="sigI" FT /locus_tag="Mb1221" FT /product="POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGI" FT /note="Mb1221, sigI, len: 290 aa. Equivalent to Rv1189, FT len: 290 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 290 aa overlap). Possible sigI, FT alternative RNA polymerase sigma factor (see citation FT below), similar to several e.g. O05767|U87307 FT extracytoplasmic function alternative sigma factor (sigE) FT from M. smegmatis (204 aa), FASTA scores: opt: 239, E(): FT 1.3e-09, (32.9% identity in 167 aa overlap)." FT /db_xref="GOA:Q7U0F6" FT /db_xref="InterPro:IPR007627" FT /db_xref="UniProtKB/TrEMBL:Q7U0F6" FT /protein_id="CAD94082.1" FT /translation="MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSRLLR FT APVGDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDGDASVSSVDPADRVTL FT DDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKIN FT ESRIAASVEPAQHRVVTRAFIEACSNGDLDTLLEVLDPGVAGEIDARKGVVVVGADRVG FT PTILRHWSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPSTLD FT PLRAELGGG" FT CDS 19630..20508 FT /transl_table=11 FT /gene="Mb1222" FT /locus_tag="Mb1222" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1222, -, len: 292 aa. Equivalent to Rv1190, len: FT 292 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 292 aa overlap). Conserved hypothetical FT protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical FT 32.2 kd protein cy1a11.10 (286 aa), fasta scores: opt: 331, FT E(): 1.4e-15, (29.0% identity in 272 aa overlap), also FT YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 FT aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity FT in 298 aa overlap)." FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7U0F5" FT /protein_id="CAD94083.1" FT /translation="MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGDGPAV FT LFVHVGSWSFVWRDVLLRLANDFRCVAIDAPGCGLSDRLSTPPTLAQAADAITSVIDAL FT QLRDLTLVAHDLGGPAGFLAAARRGDRVAALAAVNCFAWRPTGPLFRGMLAAMGSAPVR FT ELDAAINALARATSTRFGAGRHWSRADRAAFRAGIDAPARRAWHAYFRDARRAHALYTD FT VDAALRGGLADRPLLTIFGQFNDPLRFQPRWKELFPTARQLQVRRGNHFPMCDDPDLVA FT GALTSFVQRST" FT CDS 20581..21495 FT /transl_table=11 FT /gene="Mb1223" FT /locus_tag="Mb1223" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1223, -, len: 304 aa. Equivalent to Rv1191, len: FT 304 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 304 aa overlap). Conserved hypothetical FT protein, similar to Q54528 RDMC from Streptomyces FT purpurascens (298 aa), FASTA scores: opt: 196, E(): FT 1.5e-05, (27.5% identity in 269 aa overlap); FT Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E(): FT 6.6e-06, (26.4% identity in 299 aa overlap), some FT similarity to PIP_NEIGO|P42786 proline iminopeptidase (EC FT 3.4.11.5) (310 aa), FASTA scores: opt: 196, E(): 1.3e-05, FT (32.2% identity in 152 aa overlap). Contains PS00044 FT Bacterial regulatory proteins, lysR family signature." FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7U0F4" FT /protein_id="CAD94084.1" FT /translation="MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLHGTPGAR FT RQIPTEARVYAEHHNIRLIGVDRPGIGASTPHQYETILAFADDLRTIADTLGIDKMAVV FT GLSGGGPYTLACAAGLPDRVVAAGVLGGVAPTRGPDAISGGLMRLGSAVAPLLQVGGTP FT LRLGASLLIRAARPVASPALDLYGLLSPRADRHLLARPEFKAMFLDDLLNGSRKQLAAP FT FADVIAFARDWGFRLDEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESHL FT AGLGRGEEILSTLMQIWDRDLRK" FT CDS 21577..22404 FT /transl_table=11 FT /gene="Mb1224" FT /locus_tag="Mb1224" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1224, -, len: 275 aa. Equivalent to Rv1192, len: FT 275 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 275 aa overlap). Hypothetical unknown protein, FT contains PS00120 lipases, serine active site." FT /db_xref="UniProtKB/TrEMBL:Q7U0F3" FT /protein_id="CAD94085.1" FT /translation="MLLPVLEPADRPCDAPGWFLYLTDIPRAGVEYGQLLAVLPLQRML FT PAGDGHPVLVLPGLLAGDGSTWILRRILRRLGYAAYGWGLGRNIGPTAKAVSGMRDLLD FT KLHSRYHTPVSLIGWSLGGIFARGLARDHPSAVRQVITLGSPFGMRDTCETRSAWSFNR FT YAHLHTERHELPLEMESEPLPVPTTAIYSRCDGMVAWQTCMNSPSERAENIAVRSSHIG FT YGHNPPVVWAIADRLAQPQGAWAPFRPPKVLSPLFPRPDTPAEAVSTPQTRPA" FT CDS 22444..23865 FT /transl_table=11 FT /gene="fadD36" FT /locus_tag="Mb1225" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD36 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1225, fadD36, len: 473 aa. Equivalent to Rv1193, FT len: 473 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 473 aa overlap). Probable fadD36, FT fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to FT Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium FT leprae (476 aa), FASTA scores: opt: 2594, E(): 0, (81.3% FT identity in 476 aa overlap). Also highly similar to others FT e.g. CAB86109.1|AL163003 putative fatty acid synthase from FT Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 FT long-chain-fatty-acid--CoA ligase from Escherichia coli FT (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% FT identity in 364 aa overlap); etc. Contains PS00455 Putative FT AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT FT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:Q7U0F2" FT /db_xref="HSSP:1BA3" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U0F2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94086.1" FT /translation="MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVAG FT AHRVAVLATPTASTVLAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWLGPLPDD FT PAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDALAE FT AWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAHGTLF FT FGVPTVWSRVAADQAAAGALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESL FT ITLSTRADGERRPGWVGLPLAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQ FT PDATAAAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVLLGHP FT DVAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHKRPREVRIVDALPR FT NALGKVLKKQLLSEG" FT CDS complement(23898..25163) FT /transl_table=11 FT /gene="Mb1226c" FT /locus_tag="Mb1226c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1226c, -, len: 421 aa. Equivalent to Rv1194c, len: FT 421 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 421 aa overlap). Conserved hypothetical FT protein, highly similar to Q50018 possible transcriptional FT activator from Mycobacterium leprae (517 aa), FASTA scores: FT opt: 1960, E(): 0, (69.8% identity in 421 aa overlap). Also FT similar to Mycobacterium tuberculosis Rv2370c|MTCY27.10, FT (62.0% identity in 421 aa overlap) and Rv1453|MTCY493.01c." FT /db_xref="UniProtKB/TrEMBL:Q7U0F1" FT /protein_id="CAD94087.1" FT /translation="MAWQQPSPRIRELIREGARIALNPSPEWIEELDRATIAANPAIAN FT DPVLAKVVQTANRANLVYWAAANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFNIY FT RTGEHIGWRFWMGIAFELTSDPQELRELLDVSARSVNDFIEATLTGIAAQVQSEHDELT FT RSTHAERLEVVGLILDGAPISPERAEAKLGYPLSRAHTAAIIWSDELDGDHSYLDRAAD FT LFCHAVGSTRPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAPGARIAIGTTANGVEG FT FRRSHLEALITQRTLSRLRSTQRVAFFADVKMVALISQNPDAASEFITSTLGDLESASP FT DLQTALLTFINEQCNASRAAKRLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVALEAL FT QWRGNKAHALSSPGRRSNSVPA" FT CDS 25653..25952 FT /transl_table=11 FT /gene="PE13" FT /locus_tag="Mb1227" FT /product="PE FAMILY PROTEIN" FT /note="Mb1227, PE13, len: 99 aa. Equivalent to Rv1195, len: FT 99 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 99 aa overlap). Member of Mycobacterium FT tuberculosis PE family (see first citation below), e.g. FT Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kd protein FT (498 aa), FASTA scores: opt: 307, E(): 1.4e-12, (56.3% FT identity in 96 aa overlap), similar to MTCY21C12.10c (99 FT aa), FASTA scores: opt:295, E(): 1.9e-11, (51.5% identity FT in 97 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0F0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94088.1" FT /translation="MSFVMAYPEMLAAAADTLQSIGATTVASNAAAAAPTTGVVPPAAD FT EVSALTAAHFAAHAAMYQSVSARAAAIHDQFVATLASSASSYAATEVANAAAAS" FT CDS 25999..27171 FT /transl_table=11 FT /gene="PPE18" FT /locus_tag="Mb1228" FT /standard_name="mtb39a" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1228, PPE18, len: 390 aa. Equivalent to Rv1196, FT len: 391 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.0% identity in 391 aa overlap). PPE18 (alternate gene FT name: mtb39a). Member of the Mycobacterium tuberculosis PPE FT family of glycine-rich proteins, highly similar to others FT e.g. Y07P_MYCTU|Q11031 hypothetical 40.0 kDa protein FT cy02b10.25c (396 aa), FASTA scores: opt: 2124, E(): 0, FT (85.1% identity in 397 aa overlap). Note that expression of FT Rv1196 was demonstrated in lysates by immunodetection (see FT first citation below). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a 14 bp to 11 bp substitution leads to FT a slightly shorter product compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 FT aa)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7U0E9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94089.1" FT /translation="MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASDLFSAASA FT FQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGL FT TVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAAATATAT FT ATLLPFEEAPEMTSAGGLLEQAAAVEEASDTAAANQLMNNVPQALQQLAQPTQGTTPSS FT KLGGLWKTVSPHLSPISNMVSMANNHVSMTNSGVSMTNTLSSMLKGFAPAAAQAVETAA FT QNGVRAMSSLGSSLGSSGLGGGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLT FT SLTSAAERGPGQMLGGLPVGQMGARAGGGLSGVLRVPPRPYVMPHSPAAG" FT CDS 27306..27602 FT /transl_table=11 FT /gene="esxK" FT /locus_tag="Mb1229" FT /standard_name="ES6_3; TB11.0; QILSS" FT /product="PUTATIVE ESAT-6 LIKE PROTEIN 3" FT /note="Mb1229, esxK, len: 98 aa. Equivalent to Rv1197, len: FT 98 aa, from Mycobacterium tuberculosis strain H37Rv, (99.0% FT identity in 98 aa overlap). esxK, putative ESAT-6 like FT protein 3. Member of M. tuberculosis hypothetical QILSS FT protein family with Rv1038c, etc. Almost identical to FT MTCY98.023c (98 aa) (99.0% identity in 98 aa overlap) and FT MTCY10G2.11 (98 aa), FASTA scores: opt: 643, E(): 0, (99.0% FT identity in 98 aa overlap); highly similar to Q49945|U1756C FT from Mycobacterium leprae (100 aa), FASTA scores: opt: 377, FT E(): 8e-21, (58.3% identity in 96 aa overlap). BELONGS TO FT THE ESAT6 FAMILY." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:P59803" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94090.1" FT /translation="MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGW FT SGMAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS" FT CDS 27653..27937 FT /transl_table=11 FT /gene="esxL" FT /locus_tag="Mb1230" FT /standard_name="ES6_4; Mtb9.9C" FT /product="PUTATIVE ESAT-6 LIKE PROTEIN 4" FT /note="Mb1230, esxL, len: 94 aa. Equivalent to Rv1198, len: FT 94 aa, from Mycobacterium tuberculosis strain H37Rv, (98.9% FT identity in 94 aa overlap). esxL, putative ESAT-6 FT likeprotein 4. Member of the ESAT-6 family with Rv3619c, FT Rv1037c, etc. Almost identical to MTCY10G2.12 (94 aa) FT (97.9% identity in 94 aa overlap) and MTCY98.022c (94 aa) FT (94.7% identity in 94 aa overlap). Highly similar to FT Q49946|U1756D Mycobacterium leprae (95 aa), FASTA scores: FT opt: 403, E(): 1.1e-22, (64.1% identity in 92 aa overlap)." FT /db_xref="InterPro:IPR009416" FT /db_xref="UniProtKB/Swiss-Prot:P59804" FT /protein_id="CAD94091.1" FT /translation="MTINYQFGDVDDHGAMIRAQAGLLEAEHQAIIRDVLTASDFWGGA FT GSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA" FT repeat_region 27935..27942 FT /rpt_type=DIRECT FT /note="8 bp direct repeat, TGACACCA, flanking IS element FT IS1081." FT repeat_region complement(27943..29377) FT /mobile_element="insertion sequence:IS1081" FT /locus_tag="IS1081-2" FT /note="IS1081-2, len: 1435 nt. Equivalent to IS1081, len: FT 1450 nt, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1435 nt overlap). Almost identical to FT IS1081" FT repeat_region 27981..27995 FT /rpt_type=INVERTED FT /note="15 bp perfect inverted repeat, IRR, TCGCGTGATCCTTCG, FT flanking IS element IS1081." FT CDS complement(28005..29252) FT /transl_table=11 FT /gene="Mb1231c" FT /locus_tag="Mb1231c" FT /product="POSSIBLE TRANSPOSASE" FT /note="Mb1231c, -, len: 415 aa. Equivalent to Rv1199c, len: FT 415 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 415 aa overlap). Possible transposase for FT IS1081, identical to TRA1_MYCBO|P35882 transposase for FT insertion sequence element (415 aa); region identical to FT MTCY441.35 (100.0% identity in 261 aa overlap); and almost FT identical to MTCY10G2.02c (415 aa) (99.8% identity in 415 FT aa overlap). Contains PS01007 Transposases, Mutator family, FT signature, PS00435 Peroxidases proximal heme-ligand FT signature." FT /db_xref="GOA:P60231" FT /db_xref="InterPro:IPR001207" FT /db_xref="UniProtKB/Swiss-Prot:P60231" FT /protein_id="CAD94092.1" FT /translation="MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALC FT GAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALT FT SVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTF FT LAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVAR FT GLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSI FT YDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIWSNNPQE FT RLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTST FT EEPAKQQTTNTPALTT" FT repeat_region complement(29290..29304) FT /rpt_type=INVERTED FT /note="15 bp perfect inverted repeat, IRL, TCGCGTGATCCTTCG, FT flanking IS element IS1081." FT repeat_region 29378..29385 FT /rpt_type=DIRECT FT /note="8 bp direct repeat, TGACACCA, flanking IS element FT IS1081." FT CDS 29589..30866 FT /transl_table=11 FT /gene="Mb1232" FT /locus_tag="Mb1232" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT FT PROTEIN" FT /note="Mb1232, -, len: 425 aa. Equivalent to Rv1200, len: FT 425 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 425 aa overlap). Probable conserved integral FT membrane transport protein, possibly member of major FT facilitator superfamily (MFS), similar to others e.g. FT YHJE_ECOLI|P37643 hypothetical metabolite transport protein FT from Escherichia coli (440 aa), FASTA scores: opt: 1047, FT E(): 0, (39.1% identity in 427 aa overlap); etc. Contains FT PS00217 Sugar transport proteins signature 2." FT /db_xref="GOA:Q7U0E8" FT /db_xref="InterPro:IPR005828" FT /db_xref="UniProtKB/TrEMBL:Q7U0E8" FT /protein_id="CAD94093.1" FT /translation="MKRVALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAV FT ASMGTFAVAFLSRPFGAAVFGYFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGAA FT APLILTTMRLLQGFAVGGEWAGSALLSAEYAPASKRGWYGMFTVVGGGIALVLTSLTFL FT GVNYTIGESSPTFMQWGWRIPFLVSAALIAVALYVRFNIDETPVFARERADEKTRLGPA FT ETPIAQVLRRQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILFDSVLGG FT LLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVMPLIDSGSPSLFAVAVVGMYAI FT GGFGFGPTASFIPELFATSYRYTGSALAANLAGVAGGALPPVIAGALVATYGSWAIGVM FT LAILALISLVCTYRLPETAGSALVSR" FT CDS complement(30863..31816) FT /transl_table=11 FT /gene="Mb1233c" FT /locus_tag="Mb1233c" FT /product="PROBABLE TRANSFERASE" FT /EC_number="2.-.-.-" FT /note="Mb1233c, -, len: 317 aa. Equivalent to Rv1201c, len: FT 317 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 317 aa overlap). Probable transferase (EC FT 2.-.-.-). Highly similar to Q49948|U1756F Mycobacterium FT leprae (317 aa), FASTA scores: opt: 1776, E(): 0, (84.9% FT identity in 317 aa overlap), also Q46064 ORF3 protein from FT CORYNEBACTERIUM GLUTAMICUM (316 aa), FASTA scores: opt: FT 864, E(): 0, (44.1% identity in 311 aa overlap)." FT /db_xref="GOA:Q7U0E7" FT /db_xref="InterPro:IPR019875" FT /db_xref="UniProtKB/TrEMBL:Q7U0E7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94094.1" FT /translation="MSTVTGAAGIGLATLAADGSVLDTWFPAPELTESGTSATSRLAVS FT DVPVELAALIGRDDDRRTETIAVRTVIGSLDDVAADPYDAYLRLHLLSHRLVAPHGLNA FT GGLFGVLTNVVWTNHGPCAIDGFEAVRARLRRRGPVTVYGVDKFPRMVDYVVPTGVRIA FT DADRVRLGAHLAPGTTVMHEGFVNYNAGTLGASMVEGRISAGVVVGDGSDVGGGASIMG FT TLSGGGTHVISIGKRCLLGANSGLGISLGDDCVVEAGLYVTAGTRVTMPDSNSVKAREL FT SGSSNLLFRRNSVSGAVEVLARDGQGIALNEDLHAN" FT CDS 31907..32971 FT /transl_table=11 FT /gene="dapE" FT /locus_tag="Mb1234" FT /product="PROBABLE SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE FT DAPE" FT /EC_number="3.5.1.18" FT /note="Mb1234, dapE, len: 354 aa. Equivalent to Rv1202, FT len: 354 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 354 aa overlap). Probable dapE, FT succinyl-diaminopimelate desuccinylase (EC 3.5.1.18), FT similar to DAPE_CORGL|Q59284 succinyl-diaminopimelate FT desuccinylase from Corynebacterium glutamicum (369 aa), FT FASTA scores: opt: 1301, E(): 0, (55.7% identity in 359 aa FT overlap), highly similar to Q49949|U1756G (400 aa), FASTA FT scores: opt: 2045, E(): 0, (87.0% identity in 354 aa FT overlap)." FT /db_xref="GOA:Q7U0E6" FT /db_xref="InterPro:IPR011650" FT /db_xref="UniProtKB/TrEMBL:Q7U0E6" FT /protein_id="CAD94095.1" FT /translation="MLDLRGDPIELTAALIDIPSESRKEARIADEVEAALRAQASGFEI FT IRNGNAVLARTKLNRSSRVLLAGHLDTVPVAGNLPSRRENDQLHGCGAADMKSGDAVFL FT HLAATLAEPTHDLTLVFYDCEEIDSAANGLGRIQRELPDWLSADVAILGEPTAGCIEAG FT CQGTLRVVLSVTGTRAHSARSWLGDNAIHKLGAVLDRLAVYRARSVDIDGCTYREGLSA FT VRVAGGVAGNVIPDAASVTINYRFAPDRSVAAALQHVHDVFDGLDVQIEQTDAAAGALP FT GLSEPAAKALVEAAGGQVRAKYGWTDVSRFAALGIPAVNYGPGDPNLAHCRDERVPVGN FT ITAAVDLLRRYLGG" FT CDS complement(32968..33552) FT /transl_table=11 FT /gene="Mb1235c" FT /locus_tag="Mb1235c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1235c, -, len: 194 aa. Equivalent to Rv1203c, len: FT 194 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 194 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7U0E5" FT /protein_id="CAD94096.1" FT /translation="MLLAYVLITKGEFGAAASMLEPAAATLERTGYSWGPLSLMLLATA FT IAQQGHIAESAKTLQRAEARHGTKSALFAPELGLARAWTRAAAQDMTGAIAAAREAART FT AERAGQAAVALCAWHNAVRLGDIRAVDPVTRLAAEIDCTVGNILVKHARGLADGDAAEL FT TAVAEELAGIGMAAAAADATKAAARLGPQQR" FT CDS complement(33583..35271) FT /transl_table=11 FT /gene="Mb1236c" FT /locus_tag="Mb1236c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1236c, -, len: 562 aa. Equivalent to Rv1204c, len: FT 562 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 562 aa overlap). Conserved hypothetical FT protein, some similarity to Q55103 CHO-ORF2 from FT STREPTOMYCES SP. (642 aa), FASTA scores: opt: 215, E(): FT 3.6e-06, (26.4% identity in 576 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A." FT /db_xref="GOA:Q7U0E4" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U0E4" FT /protein_id="CAD94097.1" FT /translation="MRVWKHVEAAVDSPDRCGVVLVGPHGVGKTLLAQLAAEQVMSEDG FT RSGRARWVVGTAPGRAIPFGAFRHLISLPASGADIGRPAALLRAARSSLTGDAGDLLLV FT VDDAHNLDPLSATLVYQLARAGAARLVVTVASEAEPPDAIAALWSDDLLTRVAIEPLDR FT AQTAAFVESALDATLDVADADELFRRSLGNPLYLRHLIDGGGLEHVDGRWRCRDEDRRP FT LSGVIDEYLCALPEPARAVVDYLAIAEPLARTDLVALVGGEQLDTLGQAEAAGAVRVGP FT DSDTSEIFVGHPLYADRARAVLTAEHAHALRVSLVAQLAKHPSDHVSDQLRLSSLAIDV FT PASATPAAVTDAATAAGQALRLGDVRLAERLARAALDRSDALAARLPLAYALGWQGRGR FT EADAVLAAVNPAELTETELMAWAIPRAANRFWMLNEPERATAFLQTTRSRVTEPTARST FT LDALAATFAMNSGNLPRAITLATEVLSGPAADDMAVAWAASAAALSSARMGRFGDVDRL FT AERASAAEHPGLLRFTVGLAQITSLLLAGDVAPAQELAKRFTDFA" FT CDS 35366..35929 FT /transl_table=11 FT /gene="Mb1237" FT /locus_tag="Mb1237" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1237, -, len: 187 aa. Equivalent to Rv1205, len: FT 187 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 187 aa overlap). Conserved hypothetical FT protein, similar to Q49952 cosmid B1756 from Mycobacterium FT leprae (187 aa), FASTA scores: opt: 865, E(): 0, (72.4% FT identity in 174 aa overlap), also similar to FT FAS6_RHOFA|P46378 hypothetical 21.1 kd protein in FT fasciation locus (ORF6) (198 aa), FASTA scores: opt: 368, FT E(): 1.3e-17, (37.4% identity in 174 aa overlap). Some FT similarity to YJL055W Hypothetical protein in BTN1-PEP8 FT intergenic region from Saccharomyces cerevisiae and P48636 FT HYPOTHETICAL protein in AZU 5'REGION from Pseudomonas FT AERUGINOSA." FT /db_xref="InterPro:IPR005269" FT /db_xref="UniProtKB/TrEMBL:Q7U0E3" FT /protein_id="CAD94098.1" FT /translation="MSAKIDITGDWTVAVYCAASPTHAELLELAAEVGAAIAGRGWTLV FT WGGGHVSAMGAVASAARACGGWTVGVIPKMLVYRELADHDADELIVTDTMWERKQIMED FT RSDAFIVLPGGVGTLDELFDAWTDGYLGTHDKPIVMVDPWGHFDGLRAWLNGLLDTGYV FT SPTAMERLVVVDNVKDALRACAPS" FT CDS 35979..37772 FT /transl_table=11 FT /gene="fadD6" FT /locus_tag="Mb1238" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD6 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1238, fadD6, len: 597 aa. Equivalent to Rv1206, FT len: 597 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 597 aa overlap). Probable fadD6, FT fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to FT several e.g. NP_251583.1|NC_002516 probable very-long-chain FT acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa); FT Q60714 mouse fatty acid transport protein fatp (646 aa), FT FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa FT overlap); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop), and PS00455 Putative AMP-binding domain FT signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FT FAMILY." FT /db_xref="GOA:Q7U0E2" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U0E2" FT /protein_id="CAD94099.1" FT /translation="MSDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPNS FT KASIGTVFQDRAARYGDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVVGIML FT RNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAECGA FT SRGRVAGDVLTVEDVERFATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHH FT RWLRALAVFGGMGLRLKGSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRF FT WDEVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEFTTRFGVA FT RVCEFYAASEGNSAFINIFNVPRTAGVSPMPLAFVEYDLDTGDPLRDASGRVRRVPDGE FT PGLLLSRVNRLQPFDGYTDPVASEKKLVRNAFRDGDCWFNTGDVMSPQGMGHAAFVDRL FT GDTFRWKGENVATTQVEAALASDQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQ FT ALARTVYGHLPGYALPLFVRVVGSLAHTTTFKSRKVELRNQAYGADIEDPLYVLAGPDE FT GYVPYYAEYPEEVSLGRRPQG" FT CDS 37838..38794 FT /transl_table=11 FT /gene="folP2" FT /locus_tag="Mb1239" FT /product="PROBABLE DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS FT 2) (Dihydropteroate pyrophosphorylase 2)" FT /EC_number="2.5.1.15" FT /note="Mb1239, folP2, len: 318 aa. Equivalent to Rv1207, FT len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 318 aa overlap). Probable folP2, FT Dihydropteroate synthase 2 (EC 2.5.1.15), similar to many FT e.g. DHPS_ECOLI|P26282 Escherichia coli (282 aa), FASTA FT scores: opt: 480, E(): 1.9e-22, (34.4% identity in 270 aa FT overlap). Contains PS00792 dihydropteroate synthase FT signature 1, PS00793 dihydropteroate synthase signature 2." FT /db_xref="GOA:P64140" FT /db_xref="HSSP:1AD1" FT /db_xref="InterPro:IPR006390" FT /db_xref="UniProtKB/Swiss-Prot:P64140" FT /protein_id="CAD94100.1" FT /translation="MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIM FT AIVNRTPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTEITRL FT VPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDPAMPEVAAEFGAGL FT VCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAAAERAVAAGVAREKVLIDPAHDF FT GKNTFHGLLLLRHVADLVMTGWPVLMALSNKDVVGETLGVDLTERLEGTLAATALAAAA FT GARMFRVHEVAATRRVLEMVASIQGVRPPTRTVRGLA" FT CDS 38791..39765 FT /transl_table=11 FT /gene="Mb1240" FT /locus_tag="Mb1240" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1240, -, len: 324 aa. Equivalent to Rv1208, len: FT 324 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 324 aa overlap). Conserved hypothetical FT protein, similar to Q49955|U1756L Mycobacterium leprae (318 FT aa), FASTA scores, opt: 1621, E(): 0, (80.5% identity in FT 318 aa overlap)." FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q7U0E1" FT /protein_id="CAD94101.1" FT /translation="MTASELVAGDLAGGRAPGALPLDTTWHRPGWTIGELEAAKAGRTI FT SVVLPALNEEATIESVIDSISPLVDGLVDELIVLDSGSTDDTEIRAIASGARVVSREQA FT LPEVPVRPGKGEALWRSLAATSGDIVVFIDSDLINPHPLFVPWLVGPLLTGEGIQLVKS FT FYRRPLQVSDVTSGVCATGGGRVTELVARPLLAALRPELGCVLQPLSGEYAASRELLTS FT LPFAPGYGVEIGLLIDTFDRLGLDAIAQVNLGVRAHRNRPLDELGAMSRQVIATLLSRC FT GIPDSGVGLTQFLPGGPDDSDYTRHTWPVSLVDRPPMKVMRPR" FT CDS 39804..40172 FT /transl_table=11 FT /gene="Mb1241" FT /locus_tag="Mb1241" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1241, -, len: 122 aa. Equivalent to Rv1209, len: FT 122 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 122 aa overlap). Conserved hypothetical FT protein, containing a hydrophobic N-terminus. Similar to FT Q49956|U1756M hypothetical protein from Mycobacterium FT leprae (114 aa), FASTA scores: opt: 524, E(): 8.9e-29, FT (78.6% identity in 112 aa overlap)." FT /db_xref="InterPro:IPR019933" FT /db_xref="UniProtKB/TrEMBL:Q7U0E0" FT /protein_id="CAD94102.1" FT /translation="MALVLVYLVVLVLVAIVLFAAASLLFGRGEQLPPLPRATTATTLP FT AFGVTRADVDAVKFTQVLRGYKTSEVDWVLERLGRELEALRSQLGAIHASSEDAEAESD FT ASNPSRGETVVHYRSDPA" FT CDS 40169..40783 FT /transl_table=11 FT /gene="tagA" FT /locus_tag="Mb1242" FT /product="PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA FT (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) FT (DNA-3-methyladenine glycosidase I )" FT /EC_number="3.2.2.20" FT /note="Mb1242, tagA, len: 204 aa. Equivalent to Rv1210, FT len: 204 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 204 aa overlap). Probable tagA, FT DNA-3-methyladenine glycosidase I (EC 3.2.2.20), similar to FT several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine FT glycosidase I from Escherichia coli (187 aa), FASTA scores: FT opt: 530, E(): 1.3e-27, (44.2% identity in 190 aa overlap). FT Also similar to Q49957 Mycobacterium leprae cosmid B1756 FT (192 aa), FASTA scores: opt: 1042, E(): 0, (80.2% identity FT in 192 aa overlap)." FT /db_xref="GOA:Q7U0D9" FT /db_xref="HSSP:1P7M" FT /db_xref="InterPro:IPR004597" FT /db_xref="UniProtKB/TrEMBL:Q7U0D9" FT /protein_id="CAD94103.1" FT /translation="MSGDGLVRCPWAEVRPGPDAQLYRDYHDNEWGRPLYGRVALFERM FT SLEAFQSGLSWLIILRKRENFRRAFSGFDIDKIARYTDTDVRRLLADDGIVRNRAKIEA FT TIANARAAADLGSSEDLSELLWSFAPPPRPRPVDGSEIPSVSTESKAMSRELKRRGFRF FT VGPTTAYALMQATGMVDDHIQACWVPTERPFDQPGCPMAAR" FT CDS 40890..41117 FT /transl_table=11 FT /gene="Mb1243" FT /locus_tag="Mb1243" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1243, -, len: 75 aa. Equivalent to Rv1211, len: 75 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 75 aa overlap). Conserved hypothetical protein, FT similar to Q49958|U1756N Mycobacterium leprae (75 aa), FT FASTA scores: opt: 460, E(): 0, (90.7% identity in 75 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0D8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94104.1" FT /translation="MLGADQARAGGPARIWREHSMAAMKPRTGDGPLEATKEGRGIVMR FT VPLEGGGRLVVELTPDEAAALGDELKGVTS" FT CDS complement(41145..42308) FT /transl_table=11 FT /gene="Mb1244c" FT /locus_tag="Mb1244c" FT /product="PUTATIVE GLYCOSYL TRANSFERASE" FT /EC_number="2.-.-.-" FT /note="Mb1244c, -, len: 387 aa. Equivalent to Rv1212c, len: FT 387 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 387 aa overlap). Putative glycosyl FT transferase (EC 2.-.-.-), highly similar to FT AJ243803|SCO243803_2 Putative glycosyl transferase from FT Streptomyces coelicolor (387 aa), FASTA scores: opt: 1344, FT E(): 0, (54.9% identity in 388 aa overlap). Also similar to FT MJ1607 probable hexosyltransferase (EC 2.4.1.-) from FT Methanococcus jannaschii (390 aa), FASTA scores: opt: 445, FT E(): 7.8e-23, (27.9% identity in 401 aa overlap). The FT region from aa 267-355 highly similar to Q49959 COSMID FT B1756 from Mycobacterium leprae (91 aa), FASTA scores, opt: FT 471, E(): 4.8e-25, (80.9% identity in 89 aa overlap). FT Similar to Mycobacterium tuberculosis hypothetical protein, FT Rv3032." FT /db_xref="GOA:Q7U0D7" FT /db_xref="InterPro:IPR001296" FT /db_xref="UniProtKB/TrEMBL:Q7U0D7" FT /protein_id="CAD94105.1" FT /translation="MRVAMLTREYPPEVYGGAGVHVTELVAYLRRLCAVDVHCMGAPRP FT GAFAYRPDPRLGSANAALSTLSADLVMANAASAATVVHSHTWYTALAGHLAAILYDIPH FT ILTAHSLEPLRPWKKEQLGGGYQVSTWVEQTAVLAANAVIAVSSAMRNDMLRVYPSLDP FT NLVHVIRNGIDTETWYPAGPARTGSVLAELGVDPNRPMAVFVGRITRQKGVVHLVTAAH FT RFRSDVQLVLCAGAADTPEVADEVRVAVAELARNRTGVFWIQDRLTIGQLREILSAATV FT FVCPSVYEPLGIVNLEAMACATAVVASDVGGIPEVVADGITGSLVHYDADDATGYQARL FT AEAVNALVADPATAERYGHAGRQRCIQEFSWAYIAEQTLDIYRKVCA" FT CDS 42483..43697 FT /transl_table=11 FT /gene="glgC" FT /locus_tag="Mb1245" FT /product="PROBABLE GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE FT GLGC (ADP-glucose synthase) (ADP-glucose FT pyrophosphorylase)" FT /EC_number="2.7.7.27" FT /note="Mb1245, glgC, len: 404 aa. Equivalent to Rv1213, FT len: 404 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 404 aa overlap). Probable glgC, FT glucose-1-phosphate adenylyltransferase (EC 2.7.7.27), FT similar to many e.g. GLGC_ECOLI|P00584 Escherichia coli FT (430 aa), FASTA scores: opt: 1075, E(): 0, (40.3% identity FT in 407 aa overlap); highly similar to Q49961 GLGC from FT Mycobacterium leprae (419 aa), FASTA scores: opt: 2532, FT E(): 0, (92.6% identity in 404 aa overlap). BELONGS TO THE FT BACTERIAL AND PLANTS GLUCOSE-1-PHOSPHATE FT ADENYLYLTRANSFERASE FAMILY." FT /db_xref="GOA:P64242" FT /db_xref="InterPro:IPR005835" FT /db_xref="UniProtKB/Swiss-Prot:P64242" FT /protein_id="CAD94106.1" FT /translation="MREVPHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFVL FT SNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGSAD FT AIYQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVRFHIDSGAGATVAGIRVPRENATAF FT GCIDADDSGRIRSFVEKPLEPPGTPDDPDTTFVSMGNYIFTTKVLIDAIRADADDDHSD FT HDMGGDIVPRLVADGMAAVYDFSDNEVPGATDRDRAYWRDVGTLDAFYDAHMDLVSVHP FT VFNLYNKRWPIRGESENLAPAKFVNGGSAQESVVGAGSIISAASVRNSVLSSNVVVDDG FT AIVEGSVIMPGTRVGRGAVVRHAILDKNVVVGPGEMVGVDLEKDRERFAISAGGVVAVG FT KGVWI" FT CDS complement(43893..44267) FT /transl_table=11 FT /gene="PE14" FT /locus_tag="Mb1246c" FT /product="PE FAMILY PROTEIN" FT /note="Mb1246c, PE14, len: 124 aa. Equivalent to 5' end of FT Rv1214c, len: 110 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 68 aa overlap). Member of FT Mycobacterium tuberculosis PE family, appears to be FT frameshifted but sequence appears to be correct. The 5'-end FT is atypical as first 9 aa appear to be missing. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, PE14 exists as a single gene. In FT Mycobacterium bovis, a frameshift due to a 5 bp deletion FT (cttgt-*) leads to a diffferent COOH terminus." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0D6" FT /protein_id="CAD94107.1" FT /translation="MLASAATDLAGIGSALSAANAAAAAPTTAMLAACADEVSAVVASL FT FARHAQAYQALSLQATAFHQQFVPDRRWRGLCGCRSRQRCCGAERAARRAECDQRSHPG FT TVRSVTAPMADRAKTAGPGG" FT CDS complement(44401..46086) FT /transl_table=11 FT /gene="Mb1247c" FT /locus_tag="Mb1247c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1247c, -, len: 561 aa. Equivalent to Rv1215c, len: FT 561 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 561 aa overlap). Conserved hypothetical FT protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 FT hypothetical 69.9 kd protein cy1a11.08 (628 aa), FASTA FT scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa FT overlap)." FT /db_xref="GOA:Q7U0D5" FT /db_xref="InterPro:IPR013736" FT /db_xref="UniProtKB/TrEMBL:Q7U0D5" FT /protein_id="CAD94108.1" FT /translation="MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDPPADVVI FT ERDVEVPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRRRGNRWTFSPQYRMLR FT QPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTGDLLSHQEAEDTYDLVG FT WLADQSWSDGRVVMLGVSYLAISQYAVAALQPPALRAICPWEGFTDAYRDLAFPGGIRE FT SGFTRLWSRGVRRRTRQTYDMEQMQEAHPLRDDFWRSRVPDLSAIKVPMLVCGSFSDNN FT LHSRGSIRAFTRSGCGHARLYTHRGGKWETFYSATALSEQLKFLRDALAGSSGSRSVRL FT EVREDRDTITAVREETQWPLAGTRWRPMYLAGPGLLATEPPPTAGSIRFQTRSRAAAFN FT WTIPEDIELTGPMAARLWVQLDGCDDANLFVGVEKWRDGQFVAFEGSYGWGRDRVTTGW FT QRVSLRELDPELSQPWEPVPACARPRPVTAGEVVAVDVALGPSATLFRAGEQLRLVVGG FT RWLSPRNPLTGQFPAAYPRPPRGRVTLHWGPRYDAHLLIPEVPG" FT CDS complement(46114..46788) FT /transl_table=11 FT /gene="Mb1248c" FT /locus_tag="Mb1248c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb1248c, -, len: 224 aa. Equivalent to Rv1216c, len: FT 224 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 224 aa overlap). Probable conserved integral FT membrane protein, C-terminal region similar to FT Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA FT scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa FT overlap)." FT /db_xref="GOA:Q7U0D4" FT /db_xref="InterPro:IPR007269" FT /db_xref="UniProtKB/TrEMBL:Q7U0D4" FT /protein_id="CAD94109.1" FT /translation="MHIGLKIFIWGVLGLVVFGALLFGPAGTFDYWQAWVFLAAFVSTT FT IGPTIYLARNDPAALQRRMRSGPLAEGRTIQKFIVIGAFLGFFAMMVLSACDHRYGWSS FT VPAAVCVIGDVLVMTGLGIAMLVVIQNRYAASTVRVEAGQILASDGLYKIVRHPMYAGN FT VVMMTGIPLALGSYWAMFILVPGTLVLVFRILDEEKLLTQELSGYREYRQLVRYRLVPY FT VW" FT CDS complement(46797..48443) FT /transl_table=11 FT /gene="Mb1249c" FT /locus_tag="Mb1249c" FT /product="PROBABLE TETRONASIN-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER" FT /note="Mb1249c, -, len: 548 aa. Equivalent to Rv1217c, len: FT 548 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 548 aa overlap). Probable FT tetronasin-transport integral membrane ABC transporter (see FT citation below), similar to many e.g. AL049754|SCH10_12 FT probable ABC-type transport system membrane-spanning FT protein from Streptomyces coelicolor (539 aa), FASTA FT scores: opt: 1309, E(): 0, (40.9% identity in 550 aa FT overlap); Q54407|X73633 TnrB3 protein from Streptomyces FT longisporoflavus (337 aa), FASTA scores: opt: 692, E(): 0, FT (39.5% identity in 324 aa overlap); etc. Also has regions FT similar to Mycobacterium leprae proteins Q49964|U1756Q (109 FT aa), FASTA scores: opt: 431, E(): 3.1e-20, (64.8% identity FT in 105 aa overlap) and Q49965|U1756R (82 aa), FASTA scores: FT opt:154, E(): 0.0028, (61.0% identity in 41 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0D3" FT /protein_id="CAD94110.1" FT /translation="MSSTVIDRARPAGHRAPHRGSGFTGTLGLLRLYLRRDRVSLPLWV FT LLLSVPLATVYIASVETVYPDRSARAAAAAAIMASPAQRALYGPVYNDSLGAVGIWKAG FT MFHTLIAVAVILTVIRHTRADEESGRAELIDSTVVGRYTNLTGALLLSFGASIATGAIG FT ALGLLATDVAPAGSVAFGVALAASGMVFTAVAAVAAQLSPSARFTRAVAFAVLGTAFAL FT RAIGDAGSGTLSWCSPLGWSLQVRPYAGERWWVLLLSLATAAVLTVLAYRLRAGRDVGA FT GLIAERPGAGTAGPMLSEPFGLAWRLNRGSLLLWTVGLCLYGLVMGSVVHGIGDQLGDN FT TAVRDIVTRMGGTGALEQAFLALAFTMIGMVAAAFAVSLTLRLHQEETGLRAETLLAGA FT VSRTHWLASHLAMALAGSAVATLISGVAAGLAYGMTVGDVGGKLPTVVGTAAVQLPAVW FT LLSAVTVGLFGLAPRFTPVAWGVLVGFIALYLLGSLAGFPQMLLNLEPFAHIPRVGGGD FT FTAVPLLWLLAIDAALITLGAMAFRRRDVRC" FT CDS complement(48440..49375) FT /transl_table=11 FT /gene="Mb1250c" FT /locus_tag="Mb1250c" FT /product="PROBABLE TETRONASIN-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER" FT /note="Mb1250c, -, len: 311 aa. Equivalent to Rv1218c, len: FT 311 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 311 aa overlap). Probable FT tetronasin-transport ATP-binding protein ABC transporter FT (see citation below), similar to many e.g. FT Q54406|X73633|TNRB2 TNRB2 PROTEIN from Streptomyces FT longisporoflavus (300 aa), FASTA scores: opt: 1133, E(): 0, FT (60.8% identity in 291 aa overlap); etc. Also similar to FT others in Mycobacterium tuberculosis e.g. MTCY19H9.04 FT (30.0% identity in 297 aa overlap); etc. Contains PS00211 FT ABC transporters family signature and PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)" FT /db_xref="GOA:Q7U0D2" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U0D2" FT /protein_id="CAD94111.1" FT /translation="MSADNHQVPIEIRGLTKHFGSVRALDGLDLTVREGEVHGFLGPNG FT AGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLWPSLTGGETID FT LLARMRGGIDNARRAELIERFGLDPTKKARTYSKGNRQKVSLISALSSHATLLLLDEPS FT SGLDPLMENVFQQCIGEARQRGVTVLLSSHILAETEALCEKVTIIRAGKTVESGSLDAL FT RHLSRTSIKAEMIGDPGDLSRIKGVEDISIEGTTVRAQVDSESLRELIQVLGHAGVRSL FT VSQPPTLEELFLRHYSLGPEVAAEQQVATP" FT CDS complement(49365..50003) FT /transl_table=11 FT /gene="Mb1251c" FT /locus_tag="Mb1251c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1251c, -, len: 212 aa. Equivalent to Rv1219c, len: FT 212 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 212 aa overlap). Probable transcriptional FT regulatory protein, some similarity in N-terminus to FT YBIH_ECOLI|P41037 hypothetical transcriptional regulator FT from Escherichia coli (103 aa), FASTA scores: opt: 143, FT E(): 8.9e-06, (39.7% identity in 63 aa overlap); Helix turn FT helix motif from aa 28-49." FT /db_xref="GOA:Q7U0D1" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7U0D1" FT /protein_id="CAD94112.1" FT /translation="MRSADLTAHARIREAAIEQFGRHGFGVGLRAIAEAAGVSAALVIH FT HFGSKEGLRKACDDFVAEEIRSSKAAALKSNDPTTWLAQMAEIESYAPLMAYLVRSMQS FT GGELAKMLWQKMIDNAEEYLDEGVRAGTVKPSRDPRARARFLAITGGGGFLLYLQMHEN FT PTDLRAALRDYAHDMVLPSLEVYTEGLLADRAMYEAFLAEAQQGEAHVG" FT CDS complement(50145..50792) FT /transl_table=11 FT /gene="Mb1252c" FT /locus_tag="Mb1252c" FT /product="PROBABLE METHYLTRANSFERASE" FT /EC_number="2.1.1.-" FT /note="Mb1252c, -, len: 215 aa. Equivalent to Rv1220c, len: FT 215 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 215 aa overlap). Possible methyltransferase (EC FT 2.1.1.-), some similarity to MDMC_STRMY|Q00719 FT o-methyltransferase from Streptomyces mycarofaciens (221 FT aa), FASTA scores; opt: 289, E(): 1.3e-07, (30.0% identity FT in 203 aa overlap). Also similar to Mycobacterium FT tuberculosis methyltransferases Rv0187|MTCI28.26 (32.9% FT identity in 222 aa overlap) and Rv1703c. Start site chosen FT by homology; other possible start sites exist upstream." FT /db_xref="GOA:Q7U0D0" FT /db_xref="InterPro:IPR002935" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0D0" FT /protein_id="CAD94113.1" FT /translation="MPGQPAPSRGESLWAHAEGSISEDVILAGARERATDIGAGAVTPA FT VGALLCLLAKLSGGKAVAEVGTGAGVSGLWLLSGMRDDGVLTTIDIEPEHLRLARQAFA FT EAGIGPSRTRLISGRAQEVLTRLADASYDLVFIDADPIDQPDYVAEGVRLLRSGGVIVV FT HRAALGGRAGDPGARDAEVIAVREAARLIAEDERLTPALVPLGDGVLAAVRD" FT CDS 51055..51828 FT /transl_table=11 FT /gene="sigE" FT /locus_tag="Mb1253" FT /product="ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGE" FT /note="Mb1253, sigE, len: 257 aa. Equivalent to Rv1221, FT len: 257 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 257 aa overlap). sigE, alternative sigma FT factor of extracytoplasmic function (ECF) family (see FT citations below). Similar to many e.g. RPOE_HAEIN|P44790 FT RNA polymerase sigma-e factor from Haemophilus influenzae FT (189 aa), FASTA scores: opt: 247, E(): 3.4e-06, (28.5% FT identity in 186 aa overlap); etc. Also similar to FT MTCY07D11.03 rpoE from Mycobacterium tuberculosis (35.2% FT identity in 159 aa overlap). BELONGS TO THE SIGMA-70 FACTOR FT FAMILY, ECF SUBFAMILY. Note that in Mycobacterium bovis FT BCG, the sigE gene is transcribed from two promoters, P1 FT and P2, and that these promoters were expressed at FT temperatures from 30-50 C." FT /db_xref="GOA:Q7U0C9" FT /db_xref="HSSP:1OR7" FT /db_xref="InterPro:IPR007627" FT /db_xref="UniProtKB/TrEMBL:Q7U0C9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94114.1" FT /translation="MELLGGPRVGNTESQLCVADGDDLPTYCSANSEDLNITTITTLSP FT TSMSHPQQVRDDQWVEPSDQLQGTAVFDATGDKATMPSWDELVRQHADRVYRLAYRLSG FT NQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALPEDY FT DRVPADEPNPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATLGVKL FT GTVRSRIHRGRQALRDYLAAHPEHGECAVHVNPVR" FT CDS 51986..52450 FT /transl_table=11 FT /gene="Mb1254" FT /locus_tag="Mb1254" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1254, -, len: 154 aa. Equivalent to Rv1222, len: FT 154 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 154 aa overlap). Conserved hypothetical FT protein. Identical to O06290|MTU87242 (but shorter due to FT different start site chosen by proximity of RBS). FT Equivalent to O05736|U87308|MAU87308_2 hypothetical protein FT from Mycobacterium avium (133 aa), FASTA scores: opt: 644, FT E(): 7e-32, (86.2% identity in 109 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0C8" FT /protein_id="CAD94115.1" FT /translation="MADPGSVGHVFRRAFSWLPAQFASQSDAPVGAPRQFRSTEHLSIE FT AIAAFVDGELRMNAHLRAAHHLSLCAQCAAEVDDQSRARAALRDSHPIRIPSTLLGLLS FT EIPRCPPEGPSKGSSGGSSQGPPDGAAAGFGDRFADGDGGNRGRQSRVRR" FT CDS 52519..54105 FT /transl_table=11 FT /gene="htrA" FT /locus_tag="Mb1255" FT /product="PROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN)" FT /EC_number="3.4.21.-" FT /note="Mb1255, htrA, len: 528 aa. Equivalent to Rv1223, FT len: 528 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 528 aa overlap). Probable htrA FT (alternate gene name: degP), serine protease precursor (EC FT 3.4.21.-), equivalent to FT U15180|MLU15180_31|Q49972|ML1078|HTRA POSSIBLE SERINE FT PROTEASE from Mycobacterium leprae (533 aa), FASTA scores: FT opt: 2777, E(): 4.1e-141, (81.6% identity in 533 aa FT overlap). Also similar to many others e.g. FT HTRA_ECOLI|P09376 protease do precursor from Escherichia FT coli (EC 3.4.21.-) (474 aa), FASTA scores: opt: 581, E(): FT 9.1e-27, (36.3% identity in 278 aa overlap); etc. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). Start FT changed since first submission (-21 aa)." FT /db_xref="GOA:Q7U0C7" FT /db_xref="InterPro:IPR001254" FT /db_xref="UniProtKB/TrEMBL:Q7U0C7" FT /protein_id="CAD94116.1" FT /translation="MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRP FT VFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPF FT AGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSG FT KLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNA FT QEPAGRFTKVAAAVADSVVTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQ FT FKTTVVLNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGA FT PLGLRSTVTQGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVI FT GINTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPTLGINTRSVSNAIASGAQ FT VANVKAGSPAQKGGILENDVIVKVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHV FT TLTVKPDPDST" FT CDS 54107..54502 FT /transl_table=11 FT /gene="tatB" FT /locus_tag="Mb1256" FT /product="Probable protein TatB" FT /note="Mb1256, tatB, len: 131 aa. Equivalent to Rv1224, FT len: 131 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 131 aa overlap). Probable tatB, FT component of twin-arginine translocation protein export FT system (see citation below for more information). Possible FT exported protein with hydrophobic stretch at N-terminus. FT Highly similar to Q49973|U15180 hypothetical protein U1756Y FT from Mycobacterium leprae (120 aa), FASTA scores: opt: 601, FT E(): 0, (73.3% identity in 131 aa overlap)." FT /db_xref="GOA:Q7VEZ5" FT /db_xref="InterPro:IPR018448" FT /db_xref="UniProtKB/Swiss-Prot:Q7VEZ5" FT /protein_id="CAD94117.1" FT /translation="MFANIGWGEMLVLVMVGLVVLGPERLPGAIRWAASALRQARDYLS FT GVTSQLREDIGPEFDDLRGHLGELQKLRGMTPRAALTKHLLDGDDSLFTGDFDRPTPKK FT PDAAGSAGPDATEQIGAGPIPFDSDAT" FT CDS complement(54535..55365) FT /transl_table=11 FT /gene="Mb1257c" FT /locus_tag="Mb1257c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1257c, -, len: 276 aa. Equivalent to Rv1225c, len: FT 276 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 276 aa overlap). Conserved hypothetical FT protein, some similarity to other hypothetical proteins FT e.g. AE001078|AE001078_2 Archaeoglobus fulgidus (265 aa), FT FASTA scores: opt: 339, E(): 5.1e-15, (27.1% identity in FT 262 aa overlap), and to NAGD_ECOLI|P15302 nagd protein from FT Escherichia coli (250 aa), FASTA scores: opt: 167, E(): FT 6.4e-12, (24.8% identity in 258 aa overlap). Also weakly FT similar to Mycobacterium tuberculosis hypothetical protein FT Rv3400|MTCY78.28c (29.1% identity in 251 aa overlap)." FT /db_xref="GOA:Q7U0C6" FT /db_xref="InterPro:IPR006357" FT /db_xref="UniProtKB/TrEMBL:Q7U0C6" FT /protein_id="CAD94118.1" FT /translation="MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACAY FT LTNTTTRTRRQIAEALGAAGIPVAADDVITAGVLTAEYLHGAYPGARCFLVNNGDITED FT LPGIDVVLSTEIGPEDCPEAPDVVVLGSAGPQFDHRTLSRVYGWMLDGVPVVAMHRNMT FT WNTTDGLRIDTGMYLTGMEQACGKTATAIGKPAAEGFLAAADRVGVDPQQMVMIGDDLH FT NDVLAAQAVGMTGVLVRTGKFRQQTLDRWLAGASATRPHHVIDSVAGLPPLLGC" FT CDS complement(55476..56939) FT /transl_table=11 FT /gene="Mb1258c" FT /locus_tag="Mb1258c" FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT /note="Mb1258c, -, len: 487 aa. Equivalent to Rv1226c, len: FT 487 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 487 aa overlap). Probable transmembrane FT protein. Some similarity to AL049841|SCE9.01 Streptomyces FT coelicolor (436 aa), FASTA scores: opt: 203, E(): 1.2e-05, FT (29.8% identity in 346 aa overlap)." FT /db_xref="GOA:Q7U0C5" FT /db_xref="InterPro:IPR014529" FT /db_xref="UniProtKB/TrEMBL:Q7U0C5" FT /protein_id="CAD94119.1" FT /translation="MTDRPHDWHRLSPRMLLVHPVHEMLRQLPVLIGSVVLGSATGNPV FT WPLAALGVTVVFGVLRWFFTTYRIDDENVSLRTGILSRRAVSVPRNRIRSVQTEARLLH FT RLLGLTVLRVGTGQEARGEAAFELDAVDSARVPRLRALLLAESLAPVEPTGRVLARWQS FT SWLRYAPLSFSGLVMIGAVIGLGYQTGLAVRLPESGFARSAVDAAQRAGVVLVVAVTVL FT LVVGVSALLAVLFSWLTYGNLLLRRGGSGQEGVLHLRHGLLRVREHTYDMRRLRGATLR FT EPLLVRLLRGARLDAVMTGVHGEGQSSMLLPPCPFETATAVLTDLIDNTDAAAGPLRRH FT GPAAARRRWTRALLVPTLAGVALIAAAPILGVPGWAWTLWAVLTAGCAGLAVDRVRSLG FT HRVADGWLVARAGSLQRRRDCIACTGIIGWTVRQTLFQRRAGVATLVAATAAGRKGYQV FT LDVPAELAWSVAGAASPWVADSVWLRHGS" FT CDS complement(56936..57469) FT /transl_table=11 FT /gene="Mb1259c" FT /locus_tag="Mb1259c" FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT /note="Mb1259c, -, len: 177 aa. Equivalent to Rv1227c, len: FT 177 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 177 aa overlap). Possible transmembrane FT protein, similar to P96615 hypothetical protein ydbS from FT Bacillus subtilis (159 aa), fasta scores: E(): 3.6e-07, FT (30.1% identity in 163 aa overlap)." FT /db_xref="GOA:Q7U0C4" FT /db_xref="InterPro:IPR005182" FT /db_xref="UniProtKB/TrEMBL:Q7U0C4" FT /protein_id="CAD94120.1" FT /translation="MDHARNVPSATGPQRNHLALAEPAHRPSSQAPVMWALSASLGWIL FT PVIAQLVWWAVHPQPPWPHLAAAALTAVAMVVHIGVVPLWRYRVHRWEISPQAVFTRTG FT WLVQERRITPISRVQTVDTYRGPMDRLFGLANVTVTTASSAGAVHIEALDTDVADRVVA FT QLTDIAALRGEDAT" FT CDS 57564..58121 FT /transl_table=11 FT /gene="lpqX" FT /locus_tag="Mb1260" FT /product="PUTATIVE LIPOPROTEIN LPQX" FT /note="Mb1260, lpqX, len: 185 aa. Equivalent to Rv1228, FT len: 185 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 185 aa overlap). Probable lipoprotein FT LpqX. Contains possible signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="UniProtKB/TrEMBL:Q7U0C3" FT /protein_id="CAD94121.1" FT /translation="MSRQWHWLAATLLLITTAACSRPGTEEPDCPTKITLPPGATPTTT FT LDPRCIVRATTTGTADGDAASRWTGTVRIAGFYASICNAVWDGNVSLAGKDELTGKATL FT ILVETSCPGKVVAGELVLKGNVGSDSLAITWAHPELPQRAFDLGAGQGTIRRSGDRAEG FT TFNSDMGGGTEFFLTWSLTMRN" FT CDS complement(58421..59593) FT /transl_table=11 FT /gene="mrp" FT /locus_tag="Mb1261c" FT /product="PROBABLE MRP-RELATED PROTEIN MRP" FT /note="Mb1261c, mrp, len: 390 aa. Equivalent to Rv1229c, FT len: 390 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 390 aa overlap). Probable Mrp protein, FT similar to others e.g. MRP_ECOLI|P21590 mrp protein from FT Escherichia coli (379 aa), FASTA scores: E(): 0, (34.1% FT identity in 355 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop); and PS01215 MRP FT Prosite domain. BELONGS TO THE MRP/NBP35 FAMILY OF FT ATP-BINDING PROTEINS." FT /db_xref="GOA:P65442" FT /db_xref="InterPro:IPR000808" FT /db_xref="UniProtKB/Swiss-Prot:P65442" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94122.1" FT /translation="MPSRLHSAVMSGTRDGDLNAAIRTALGKVIDPELRRPITELGMVK FT SIDTGPDGSVHVEIYLTIAGCPKKSEITERVTRAVADVPGTSAVRVSLDVMSDEQRTEL FT RKQLRGDTREPVIPFAQPDSLTRVYAVASGKGGVGKSTVTVNLAAAMAVRGLSIGVLDA FT DIHGHSIPRMMGTTDRPTQVESMILPPIAHQVKVISIAQFTQGNTPVVWRGPMLHRALQ FT QFLADVYWGDLDVLLLDLPPGTGDVAISVAQLIPNAELLVVTTPQLAAAEVAERAGSIA FT LQTRQRIVGVVENMSGLTLPDGTTMQVFGEGGGRLVAERLSRAVGADVPLLGQIPLDPA FT LVAAGDSGVPLVLSSPDSAIGKELHSIADGLSTRRRGLAGMSLGLDPTRR" FT CDS complement(59606..60841) FT /transl_table=11 FT /gene="Mb1262c" FT /locus_tag="Mb1262c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb1262c, -, len: 411 aa. Equivalent to Rv1230c, len: FT 411 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 411 aa overlap). Possible membrane FT protein with two hydrophobic stretches near N-terminus. FT Some similarity to Rv1022|MTCY10G2.27c|Z92539 probable lpqU FT protein from Mycobacterium tuberculosis (243 aa), FASTA FT score: opt: 408, E(): 1e-11, (43.6% identity in 172 aa FT overlap). Similar to AL133423|SC4A7.37 hypothetical protein FT from Streptomyces coelicolor (421 aa), FASTA score: opt: FT 679, E(): 5.1e-23, (36.4% identity in 398 aa overlap)." FT /db_xref="GOA:Q7U0C2" FT /db_xref="InterPro:IPR001827" FT /db_xref="UniProtKB/TrEMBL:Q7U0C2" FT /protein_id="CAD94123.1" FT /translation="MHIGGRWGARPAVAAVRRGACRLTRAPAFGVAAIAPLVFASAVGG FT AAPVFPGRTAPVHAVITPVAAVAASGIDLSGPVVIAMKRPPTSFRVAVATIPAPPPPMI FT VNSPGALGIPAMALSAYRNAELKMAAAAPGCGVSWNLLAGIGRIESMHANGGATDARGT FT AIQPIYGPTLDGTLPGNEIIIQSSVGNRVTYARAMGPMQFLPGTWARYATDGDDDGVAD FT PQNLFDSTLAAARYLCSGGLNLRDPAQVMAALLRYNNSMPYAQNVLGWAAGYATGVFPV FT DLPPITGPPPPLGDAHLENPEGLGPGLPINVNGLTADGPMAHLPLIDLTPRQAALNPPP FT MFPWMAPDPSAPMPGCTLICIGSHGPPVGAPPFPPTAPPPPFLPAAPPPPDPLAGPPGD FT AGLAPPAPAPAG" FT CDS complement(60966..61508) FT /transl_table=11 FT /gene="Mb1263c" FT /locus_tag="Mb1263c" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb1263c, -, len: 180 aa. Equivalent to Rv1231c, len: FT 180 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 180 aa overlap). Probable membrane protein, FT similar to others e.g. AL390975 Streptomyces coelicolor FT (198 aa)." FT /db_xref="InterPro:IPR010406" FT /db_xref="UniProtKB/TrEMBL:Q7U0C1" FT /protein_id="CAD94124.1" FT /translation="MSKPFAPRRLYTPRTSRTLAPRLDPEAVGRTTESIARFFGTGRYL FT LVQTLLVLTWIVLNLFAVGLRWDPYPFILLNLAFSTQASYAAPLILLAQNRQEKRDRAV FT FEEDRRRAAQTKADTEYNARELAALRLAIGEVPTRDYLRHELDSLRALLAELQPTDPDV FT AQPRVADEAEQHAKKSG" FT CDS complement(61505..62812) FT /transl_table=11 FT /gene="Mb1264c" FT /locus_tag="Mb1264c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1264c, -, len: 435 aa. Equivalent to Rv1232c, len: FT 435 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 435 aa overlap). Conserved hypothetical FT protein, similar to other hypothetical proteins e.g. FT AB013374|AB013374_2 Bacillus halodurans C-125 mamX (449 FT aa), FASTA scores: opt: 381, E(): 1e-16, (29.9% identity in FT 251 aa overlap). Some similarity in N-terminus to FT U15180|MLU1518033 hypothetical Mycobacterium leprae protein FT u1756u (329 aa), FASTA scores: opt: 300, E(): 4.1e-12, FT (69.3% identity in 75 aa overlap)." FT /db_xref="InterPro:IPR006668" FT /db_xref="UniProtKB/TrEMBL:Q7U0C0" FT /protein_id="CAD94125.1" FT /translation="MGSVNRVYLARLSRMSVLGPLGESFGRVRDVVISISIVRQQPRVL FT GLVVDLATRRKIFIPILRVAAIEPHAVTLSTGNVSLHRFEQRPGEALALGQVLDTLVKV FT NDPALPELAGVDVVVTDLGVEQTRSRDWMVTRVAVRTQRRLRRRGPVHVVDWHNVAGLT FT PSALAMPGQDVAQLLDQFEGWKAVDVADAIRGLPPKRRHEVFKALHDKRLADVLQELPE FT LDQAEVLSQLGTERAADVLEEMDPDDAADLLAVLNPTEAELLLTRMDPGDSGQVRRLLT FT HSPDTAGGLMTSDPVVLTPDTSIAEALARVRDPDLTPALASMVFVARPPTATPTGHYLG FT CVHLQRLLRDPPAELVGGVVDTDLLTLTPETPLAAVTRYFAAYNLVCGPVVDDENHLLG FT AVTVDDLLDHLLPHDWRVDMPELDPSGAPDRPGGPR" FT CDS complement(62874..63470) FT /transl_table=11 FT /gene="Mb1265c" FT /locus_tag="Mb1265c" FT /product="CONSERVED HYPOTHETICAL MEMBRANE PROTEIN" FT /note="Mb1265c, -, len: 198 aa. Equivalent to Rv1233c, len: FT 198 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.0% identity in 198 aa overlap). Conserved hypothetical FT membrane protein, N-terminus is highly proline rich, FT C-terminus has two hydrophobic stretches. Proline-rich FT N-terminus has some similarity to CBPA_DICDI calcium FT binding protein from Dictyostelium discoideum (467 aa), FT FASTA scores: E(): 4.8e-06, (35.5% identity in 183 aa FT overlap). Both sequences share multiple copies of a FT Tyr-Pro-Pro motif." FT /db_xref="UniProtKB/TrEMBL:Q7U0B9" FT /protein_id="CAD94126.1" FT /translation="MTAPSGSSGESAHDAAGGPPPVGERPPEQPIADAPWAPPASSPMA FT DHPPPAYPPSGYPPAYQPGYPTDYPPPMPPGGYAPPGYPPPGTSSAGYGDIPYPPMPPP FT YGGSPGGYYPEPGYLDGYGPSQPGMNTMALVSLISALVGVLCCIGSIVGIVFGAIAINQ FT IKQTREEGYGLAVAGIVIGIATLLVYMIAGIFAIP" FT CDS 63620..64147 FT /transl_table=11 FT /gene="Mb1266" FT /locus_tag="Mb1266" FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT /note="Mb1266, -, len: 175 aa. Equivalent to Rv1234, len: FT 175 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 175 aa overlap). Possible transmembrane protein FT with two TM helices." FT /db_xref="GOA:Q7U0B8" FT /db_xref="UniProtKB/TrEMBL:Q7U0B8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94127.1" FT /translation="MTSPFQPRQVPGSTPAAAGAGRRGVPALPTPPKGWPVGSYPTYAE FT AQRAVDYLSEQQFPVQQVTIVGVDLMQVERVTGRLTWPKVLGGGVLSGAWLGLFIGLVL FT GFFSPNPWSALVTGLVAGVFFGLITSAVPYAMARGTRDFSSTMQLVAGRYDVLCDPQNA FT EKARDLLARLAI" FT CDS 64168..65574 FT /transl_table=11 FT /gene="lpqY" FT /locus_tag="Mb1267" FT /product="PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY" FT /note="Mb1267, lpqY, len: 468 aa. Equivalent to Rv1235, FT len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 468 aa overlap). Probable lpqY, FT sugar-binding lipoprotein component of sugar transport FT system (see citation below), equivalent to MLU1518034 FT protein u1756v from Mycobacterium leprae (469 aa), FASTA FT scores: opt: 2442, E(): 0, (77.4% identity in 470 aa FT overlap). Also similar to P18815|MALE_ENTAE MALTOSE-BINDING FT PERIPLASMIC PROTEIN from Enterobacter aerogenes (396 aa), FT FASTA scores: opt: 193, E(): 2.3e-05, (24.2% identity in FT 297 aa overlap). Contains PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="GOA:O31095" FT /db_xref="InterPro:IPR006059" FT /db_xref="UniProtKB/TrEMBL:O31095" FT /protein_id="CAD94128.1" FT /translation="MVMSRGRIPRLGAAVLVALTTAAAACGADSQGLVVSFYTPATDGA FT TFTAIAQRCNQQFGGRFTIAQVSLPRSPNEQRLQLARRLTGNDRTLDVMALDVVWTAEF FT AEAGWALPLSDDPAGLAENDAVADTLPGPLATAGWNHKLYAAPVTTNTQLLWYRPDLVN FT SPPTDWNAMIAEAARLHAAGEPSWIAVQANQGEGLVVWFNTLLVSAGGSVLSEDGRHVT FT LTDTPAHRAATVSALQILKSVATTPGADPSITRTEEGSARLAFEQGKAALEVNWPFVFA FT SMLENAVKGGVPFLPLNRIPQLAGSINDIGTFTPSDEQFRIAYDASQQVFGFAPYPAVA FT PGQPAKVTIGGLNLAVAKTTRHRAEAFEAVRCLRDQHNQRYVSLEGGLPAVRASLYSDP FT QFQAKYPMHAIIRQQLTDAAVRPATPVYQALSIRLAAVLSPITEIDPESTADELAAQAQ FT KAIDGMGLLP" FT CDS 65571..66494 FT /transl_table=11 FT /gene="sugA" FT /locus_tag="Mb1268" FT /product="PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER SUGA" FT /note="Mb1268, sugA, len: 307 aa. Equivalent to Rv1236, FT len: 307 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 307 aa overlap). Probable sugA, FT sugar-transport integral membrane protein ABC transporter FT (see citation below), equivalent to U15180|MLU1518035 FT protein malFM from Mycobacterium leprae (310 aa), FASTA FT scores: opt: 1566, E(): 0, (81.8% identity in 292 aa FT overlap). Also similar to numerous bacterial sugar FT transport system components. Also similar to FT Rv2316|MTCY3G12.18c from Mycobacterium tuberculosis (290 FT aa), FASTA scores: opt: 514, E(): 7.3e-27, (33.2% identity FT in 283 aa overlap). Contains PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp signature." FT /db_xref="GOA:Q7U0B7" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q7U0B7" FT /protein_id="CAD94129.1" FT /translation="MTSVEQRTATAVFSRTGSRMAERRLAFMLVAPAAMLMVAVTAYPI FT GYALWLSLQRNNLATPNDTAFIGLGNYHTILIDRYWWTALAVTLAITAVSVTIEFVLGL FT ALALVMHRTLIGKGLVRTAVLIPYGIVTVVASYSWYYAWTPGTGYLANLLPYDSAPLTQ FT QIPSLGIVVIAEVWKTTPFMSLLLLAGLALVPEDLLRAAQVDGASAWRRLTKVILPMIK FT PAIVVALLFRTLDAFRIFDNIYVLTGGSNNTGSVSILGYDNLFKGFNVGLGSAISVLIF FT GCVAVIAFIFIKLFGAAAPGGEPSGR" FT CDS 66499..67323 FT /transl_table=11 FT /gene="sugB" FT /locus_tag="Mb1269" FT /product="PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER SUGB" FT /note="Mb1269, sugB, len: 274 aa. Equivalent to Rv1237, FT len: 274 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 274 aa overlap). Probable sugB, FT sugar-transport integral membrane protein ABC transporter FT (see citation below), equivalent to U15180|MLU1518036 FT protein MalGM from Mycobacterium leprae (296 aa), FASTA FT scores: opt: 1571, E(): 0, (89.8% identity in 274 aa FT overlap). Also similar to numerous bacterial sugar FT transport protein. Related to Rv2834c|MTCY16B7.08 from FT Mycobacterium tuberculosis (275 aa), FASTA scores: opt: FT 370, E(): 2.4e-17, (26.8% identity in 269 aa overlap)." FT /db_xref="GOA:Q7U0B6" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q7U0B6" FT /protein_id="CAD94130.1" FT /translation="MGARRATYWAVLDTLVVGYALLPVLWIFSLSLKPTSTVKDGKLIP FT STVTFDNYRGIFRGDLFSSALINSIGIGLITTVIAVVLGAMAAYAVARLEFPGKRLLIG FT AALLITMFPSISLVTPLFNIERAIGLFDTWPGLILPYITFALPLAIYTLSAFFREIPWD FT LEKAAKMDGATPGQAFRKVIVPLAAPGLVTAAILVFIFAWNDLLLALSLTATKAAITAP FT VAIANFTGSSQFEEPTGSIAAGAIVITIPIIVFVLIFQRRIVAGLTSGAVKG" FT CDS 67328..68509 FT /transl_table=11 FT /gene="sugC" FT /locus_tag="Mb1270" FT /product="PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC FT TRANSPORTER SUGC" FT /note="Mb1270, sugC, len: 393 aa. Equivalent to Rv1238, FT len: 393 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 393 aa overlap). Probable sugC, FT sugar-transport ATP-binding protein ABC transporter (see FT citation below). Highly similar to U15180 protein ugpC from FT Mycobacterium leprae (392 aa), FASTA score: opt: 2007, E(): FT 0, (79.9% identity in 389 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop) and PS00211 ABC FT transporters family signature. BELONGS TO THE ATP-BINDING FT TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7U0B5" FT /db_xref="HSSP:1G29" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U0B5" FT /protein_id="CAD94131.1" FT /translation="MAEIVLDHVNKSYPDGHTAVRDLNLTIADGEFLILVGPSGCGKTT FT TLNMIAGLEDISSGELRIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLTLA FT KMRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQRVAMGRAIVRHPKAFLMDEPLS FT NLDAKLRVQMRGEIAQLQRRLGTTTVYVTHDQTEAMTLGDRVVVMYGGIAQQIGTPEEL FT YERPANLFVAGFIGSPAMNFFPARLTAIGLTLPFGEVTLAPEVQGVIAAHPKPENVIVG FT VRPEHIQDAALIDAYQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQLDELAEV FT EGESALHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTIPHRA" FT CDS complement(68586..69686) FT /transl_table=11 FT /gene="corA" FT /locus_tag="Mb1271c" FT /product="POSSIBLE MAGNESIUM AND COBALT TRANSPORT FT TRANSMEMBRANE PROTEIN CORA" FT /note="Mb1271c, corA, len: 366 aa. Equivalent to Rv1239c, FT len: 366 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 366 aa overlap). Possible corA, FT magnesium and cobalt transport transmembrane protein, FT highly similar to U15180 corA protein from Mycobacterium FT leprae (373 aa), FASTA scores: opt: 1985, E(): 0, (79.1% FT identity in 369 aa overlap). Also similar to various CorA FT proteins of Gram negative bacteria e.g. FT P27841|CORA_ECOLI|B3816|Z5333|ECS4746 Magnesium and cobalt FT transport protein from Escherichia coli strains K12 and FT O157:H7 (316 aa), FASTA scores: opt: 236, E(): 8e-08, FT (24.5% identity in 306 aa overlap); etc. SEEMS TO BELONG TO FT THE MIT FAMILY." FT /db_xref="GOA:Q7U0B4" FT /db_xref="InterPro:IPR002523" FT /db_xref="UniProtKB/TrEMBL:Q7U0B4" FT /protein_id="CAD94132.1" FT /translation="MFPGFDALPEVLRPVARPQPPNAHPVAQPPAQALVDCGVYVCGQR FT LPGKYTYAAALREVREIELTGQEAFVWIGLHEPDENQMQDVADVFGLHPLAVEDAVHAH FT QRPKLERYDETLFLVLKTVNYVPHESVVLAREIVETGEIMIFVGKDFVVTVRHGEHGGL FT SEVRKRMDADPEHLRLGPYAVMHAIADYVVDRYLEVTNLMETDIDSIEEVAFAPGRKLD FT IEPIYLLKREVVELRRCVNPLSTAFQRMQTESKDLISKEVRRYLRDVADHQTEAADQIA FT SYDDMLNSLVQAALARVGMQQNMDMRKISAWAGIIAVPTMIAGIYGMNFHFMPELDSRW FT GYPTVIGGMVLICLFLYHVFRNRNWL" FT CDS 69857..70846 FT /transl_table=11 FT /gene="mdh" FT /locus_tag="Mb1272" FT /product="PROBABLE MALATE DEHYDROGENASE MDH" FT /EC_number="1.1.1.37" FT /note="Mb1272, mdh, len: 329 aa. Equivalent to Rv1240, len: FT 329 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 329 aa overlap). Probable mdh, Malate FT dehydrogenase (EC 1.1.1.37). Most similar to FT P50917|MDH_MYCLE MALATE DEHYDROGENASE from Mycobacterium FT leprae (329 aa), FASTA scores: opt: 1887, E(): 0, (89.1% FT identity in 329 aa overlap). Contains PS00068 Malate FT dehydrogenase active site signature. BELONGS TO THE LDH FT FAMILY. MDH SUBFAMILY." FT /db_xref="GOA:P0A5J7" FT /db_xref="HSSP:1BDM" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P0A5J7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94133.1" FT /translation="MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIE FT PALQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDLLE FT ANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNR FT AISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIEDEFIP FT TVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLI FT SSFPVTTKGGNWTIVSGLEIDEFSRGRIDKSTAELADERSAVTELGLI" FT CDS 70922..71182 FT /transl_table=11 FT /gene="Mb1273" FT /locus_tag="Mb1273" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1273, -, len: 86 aa. Equivalent to Rv1241, len: 86 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 86 aa overlap). Conserved hypothetical protein, FT member of family of 16 hypothetical M. tuberculosis FT proteins including: Rv2871|Q10799|YS71_MYCTU HYPOTHETICAL FT 13.2 KD PROTEIN CY2 (124 aa), FASTA scores: opt: 172, E(): FT 9.5e-06, (37.2% identity in 86 aa overlap); Rv2132, FT Rv3321c, etc." FT /db_xref="UniProtKB/TrEMBL:Q7U0B3" FT /protein_id="CAD94134.1" FT /translation="MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQ FT EQYRLEPHESAVRSGLDLAGFNKLADELEDEALLDATRRAR" FT CDS 71179..71610 FT /transl_table=11 FT /gene="Mb1274" FT /locus_tag="Mb1274" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1274, -, len: 143 aa. Equivalent to Rv1242, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 143 aa overlap). Conserved hypothetical FT protein, member of family of 14 hypothetical M. FT tuberculosis proteins including: Rv2872|Q10800|YS72_MYCTU FT (147 aa), FASTA scores: opt: 226, E(): 2.7e-09, (32.1% FT identity in 137 aa overlap); Rv0749, Rv0277c, Rv2530c, FT etc." FT /db_xref="InterPro:IPR006226" FT /db_xref="UniProtKB/TrEMBL:Q7U0B2" FT /protein_id="CAD94135.1" FT /translation="MIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALF FT GFLRIATSARVLAAPLPTADAIAYVREWLSQPNVDLLTAGPRHLDIALGLLDKLGTASH FT LTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE" FT CDS complement(71633..73321) FT /transl_table=11 FT /gene="PE_PGRS23" FT /locus_tag="Mb1275c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1275c, PE_PGRS23, len: 562 aa. Equivalent to FT Rv1243c, len: 562 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 562 aa overlap). Member of FT the Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0B1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94136.1" FT /translation="MEYLIAAQDVLVAAAADLEGIGSALAAANRAAEAPTTGLLAAGAD FT EVSAAIASLFSGNAQAYQALSAQAAAFHQQFVRALSSAAGSYAAAEAANASPMQAVLDV FT VNGPTQLLLGRPLIGDGANGGPGQNGGDGGLLYGNGGNGGSSSTPGQPGGRGGAAGLIG FT NGGAGGAGGPGANGGAGGNGGWLYGNGGLGGNGGAATQIGGNGGNGGHGGNAGLWGNGG FT AGGAGAAGAAGANGQNPVSHQVTHATDGADGTTGPDGNGTDAGSGSNAVNPGVGGGAGG FT IGGDGTNLGQTDVSGGAGGDGGDGANFASGGAGGNGGAAQSGFGDAVGGNGGAGGNGGA FT GGGGGLGGAGGSANVANAGNSIGGNGGAGGNGGIGAPGGAGGAGGNANQDNPPGGNSTG FT GNGGAGGDGGVGASADVGGAGGFGGSGGRGGLLLGTGGAGGDGGVGGDGGIGAQGGSGG FT NGGNGGIGADGMANQDGDGGDGGNGGDGGAGGAGGVGGNGGTGGAGGLFGQSGSPGSGA FT AGGLGGAGGNGGAGGGGGTGFNPGAPGDPGTQGATGANGQHGLNG" FT CDS 73501..74361 FT /transl_table=11 FT /gene="lpqZ" FT /locus_tag="Mb1276" FT /product="PUTATIVE LIPOPROTEIN LPQZ" FT /note="Mb1276, lpqZ, len: 286 aa. Equivalent to Rv1244, FT len: 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 286 aa overlap). Probable lipoprotein FT lpqZ, equivalent to U15180|MLU1518042 protein u1756x from FT Mycobacterium leprae (228 aa), FASTA scores: opt: 1039, FT E(): 0, (72.5% identity in 229 aa overlap). Similar to M. FT tuberculosis hypothetical protein Rv3759c. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q7U0B0" FT /db_xref="InterPro:IPR007210" FT /db_xref="UniProtKB/TrEMBL:Q7U0B0" FT /protein_id="CAD94137.1" FT /translation="MRITRILALLLAVLLAVSGVAGCSADTGDRHPELVVGSTPDSEAM FT LLAAIYVAALRSYGFAAHAETAADPVAKLDSGAFTVVPAFTGQMLQTLQPDASVRSDAQ FT VYRAIVSALPEGIAAGDYTTAAEDKPALVVTQSTAKAWGGGDLSELPSHCRGLLVGRVA FT GAHTPAAVGPCRLPAPREFRNDATMFAALRAGQLVAAWTTTADPDIPADLIMLTDGKPA FT LIRAENIVPLYRRNALTERKLLAVNEVAGVLDTTALIGMRRQVAAGADPAAVAAGWLAE FT HPLGR" FT CDS complement(74442..75272) FT /transl_table=11 FT /gene="Mb1277c" FT /locus_tag="Mb1277c" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1277c, -, len: 276 aa. Equivalent to Rv1245c, len: FT 276 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 276 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), equivalent to FT NP_301801.1|NC_002677 short chain alcohol dehydrogenase FT from Mycobacterium leprae (277 aa). Also highly similar to FT various dehydrogenases and oxidoreductases e.g. FT NP_250228.1|NC_002516 probable short-chain dehydrogenase FT from Pseudomonas aeruginosa (295 aa); NP_421969.1|NC_002696 FT short chain dehydrogenase family protein from Caulobacter FT crescentus (278 aa); etc. Also highly similar to others FT from Mycobacterium tuberculosis e.g. Rv3085|MTV013.06 FT PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE (276 aa), FT FASTA scores: opt: 368, E(): 1.2e-16, (35.3% identity in FT 224 aa overlap); Rv3057c|MTCY22D7.24 PUTATIVE SHORT CHAIN FT ALCOHOL DEHYDROGENASE/REDUCTASE (287 aa), FASTA scores: FT opt: 471, E(): 1.3e-21, (32.4% identity in 281 aa overlap); FT etc. Contains PS00061 Short-chain dehydrogenases/reductases FT family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7U0A9" FT /db_xref="HSSP:1FDW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U0A9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94138.1" FT /translation="MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDGLAD FT TEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTGDIEVSQF FT KDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLFSAPGQAAYNSAKFAVR FT GFTEALRQEMALAGHPVKVTTVHPGGVKTAIARNATAAEGLDQAELAETFDKRVAHLSP FT QRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFPIITGRLIPRPR" FT CDS complement(75329..75622) FT /transl_table=11 FT /gene="Mb1278c" FT /locus_tag="Mb1278c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1278c, -, len: 97 aa. Equivalent to Rv1246c, len: FT 97 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 97 aa overlap). Conserved hypothetical protein, FT highly similar to Rv2866|MTV003.12 hypothetical FT Mycobacterium tuberculosis protein (87 aa), FASTA scores: FT opt: 290, E(): 3.9e-24, (54.1% identity in 85 aa overlap)." FT /db_xref="InterPro:IPR007712" FT /db_xref="UniProtKB/TrEMBL:Q7U0A8" FT /protein_id="CAD94139.1" FT /translation="MSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRL FT GKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEIIHIARRSASYRMNPCRPR" FT CDS complement(75619..75888) FT /transl_table=11 FT /gene="Mb1279c" FT /locus_tag="Mb1279c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1279c, -, len: 89 aa. Equivalent to Rv1247c, len: FT 89 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 89 aa overlap). Conserved hypothetical protein, FT some similarity to hypothetical proteins including FT Mycobacterium tuberculosis proteins Rv2865|MTV003.11 (93 FT aa), FASTA scores: opt: 249, E(): 5.4e-13, (44.2% identity FT in 86 aa overlap); Rv0268|Z86089|P95225 (169 aa) opt: 125, FT E(): 0.0089, (41.8% identity in 55 aa overlap); etc. and FT AE000293|ECAE0002933 from Escherichia coli (92 aa), FASTA FT scores: opt: 127, E(): 0.0038, (29.3% identity in 82 aa FT overlap)." FT /db_xref="InterPro:IPR006442" FT /db_xref="UniProtKB/TrEMBL:Q7U0A7" FT /protein_id="CAD94140.1" FT /translation="MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDL FT ASIEETLEVLRTPGASEAIREGLADVAAGRFVSNDEIRNRYTAR" FT CDS complement(76001..79645) FT /transl_table=11 FT /gene="sucA" FT /locus_tag="Mb1280c" FT /product="PROBABLE 2-OXOGLUTARATE DEHYDROGENASE SUCA FT (Alpha-ketoglutarate dehydrogenase)" FT /EC_number="1.2.4.2" FT /note="Mb1280c, sucA, len: 1214 aa. Equivalent to Rv1248c, FT len: 1214 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1214 aa overlap). Probable sucA, FT 2-oxoglutarate dehydrogenase (EC 1.2.4.2), highly similar FT to several but closest to D84102 Corynebacterium glutamicum FT (1257 aa), FASTA scores: opt: 4418, E(): 0, (59.4% identity FT in 1223 aa overlap)." FT /db_xref="GOA:Q7U0A6" FT /db_xref="HSSP:1E2O" FT /db_xref="InterPro:IPR005475" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0A6" FT /protein_id="CAD94141.1" FT /translation="MYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAE FT RAAAAAPQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSAS FT LEVPTATSVRAVPAKLLIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRH FT YTEVDGKPTAVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRR FT ARDGKLTTEDFAGVTISLTNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEER FT IAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRW FT STDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWD FT LDRVFKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVK FT PTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDE FT VVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFG FT DNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAF FT AGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIF FT HVNGDDPEACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYMYDVVDT FT KRGARKSYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHGVQPSESVESDQ FT MIPAGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKIDWAFGELL FT ALGSLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKF FT LVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQL FT SNVVLLLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQ FT RPLIVFTPKSMLRHKAAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLY FT YELAARKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPR FT FGLELPELLPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFG" FT CDS complement(79838..80626) FT /transl_table=11 FT /gene="Mb1281c" FT /locus_tag="Mb1281c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb1281c, -, len: 262 aa. Equivalent to Rv1249c, len: FT 262 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 262 aa overlap). Possible membrane FT protein. Start uncertain." FT /db_xref="UniProtKB/TrEMBL:Q7U0A5" FT /protein_id="CAD94142.1" FT /translation="MSARRIRSWKRFDNRSANAAEPDPQLAGTGGRPKVSTRALAQVIE FT RSSRIQGPAAQAYVARLRRAHPGASPAKIVAKLEKRFLSVVTASGAAVGTAATLPGIGT FT LAAWFAAAGEVVVFLEATALFVLALASVHAIPLDHRERRRALVLAVLVGDNTTAVADLL FT GPGRTSGGWVSETMASLPLPAISSLNSRMLKYVVKRFALKRGALMFGKLVPMGIGAIIG FT AIGNRLVGKKLVRNARSAFGTPPARWPVTLHVLPTVRDAS" FT CDS 80823..82562 FT /transl_table=11 FT /gene="Mb1282" FT /locus_tag="Mb1282" FT /product="PROBABLE DRUG-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN" FT /note="Mb1282, -, len: 579 aa. Equivalent to Rv1250, len: FT 579 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 579 aa overlap). Probable drug-transport FT integral membrane protein, member of major facilitator FT superfamily (MFS), highly similar to several including FT P39886|TCMA_STRGA TETRACENOMYCIN C RESISTANCE PROTEIN from FT Streptomyces glaucescens (538 aa), FASTA scores: opt: 847, FT E(): 0, (32.9% identity in 517 aa overlap); etc. Also FT similar to MTCY20B11.14c|Rv3239C from Mycobacterium FT tuberculosis (1048 aa), FASTA scores: opt: 629, E(): FT 6.7e-13, (31.9% identity in 423 aa overlap). TBparse score FT is 0.921." FT /db_xref="GOA:Q7U0A4" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q7U0A4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94143.1" FT /translation="MTTAIRRAAGSSYFRNPWPALWAMMVGFFMIMLDSTVVAIANPTI FT MAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYLIGLGVFTVASLGCGLS FT SGAGMLIAARVVQGVGAGLLTPQTLSTITRIFPAHRRGVALGAWGTVASVASLVGPLAG FT GALVDSMGWEWIFFVNVPVGVIGLILAAYLIPALPHHPHRFDWFGVGLSGAGMFLIVFG FT LQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNAREPLIPLEVFNDRNFSLSNLGIAI FT IAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAPFVGMIIDRSHPLCVLG FT FGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAFVWSPLTVTATRNLRPHLAGA FT SSGVFNAVRQLGAVLGSASMAAFMTSRIAAEMPGGVDALTGPAGQDATVLQLPEFVREP FT FAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAVAKEPLPESDGDADDDDYVEYILRRE FT PEEDCDTQPLRASRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRAWQADTESTAP FT SAL" FT CDS complement(82465..85884) FT /transl_table=11 FT /gene="Mb1283c" FT /locus_tag="Mb1283c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1283c, -, len: 1139 aa. Equivalent to Rv1251c, FT len: 1139 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 1139 aa overlap). Conserved hypothetical FT protein, showing some similarity in C-terminal region with FT other proteins from eukaryotes and bacteria e.g. FT NP_142121.1 hypothetical protein from Pyrococcus horikoshii FT (1188 aa); and some similarity to GTP-binding proteins e.g. FT P23249|MV10_MOUSE PUTATIVE GTP-BINDING PROTEIN (1004 aa), FT FASTA scores: opt: 228, E(): 1.7e-06, (27.7% identity in FT 560 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /db_xref="GOA:Q7U0A3" FT /db_xref="InterPro:IPR019993" FT /db_xref="UniProtKB/TrEMBL:Q7U0A3" FT /protein_id="CAD94144.1" FT /translation="MFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDEL FT MARAAVLGSAHEGRRLDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPVVY FT QAAMFDGRFVGFADFLIRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPVAAD FT AELELGDGTIVRYRVGELIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQC FT TERLRASDDLLLVGGMRVRQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLTAQAKL FT QIRQRDTGAPQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYLFGVLEA FT GRAGVFRPLWAHDRTAERQALTDFLAIVARRRRRHPNMHIYHYAPYEKTALLRLVGRYG FT IGEDDVDDLLRNGVLVDLYPLVRKSIRVGTDSFSLKALEPLYLGTQPRSGDVTTAADSI FT NSYARYCELRAAGRIDEAATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQP FT VPDADPIDDGDSLASVLSKFTGDAAAGERTPEQTAVALLAAARGYHRREDKPFWWAHFD FT RLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTGELARGDLNGNVFALY FT EPPAPPGMTDNPDRRAAGPAAVVETDDPTVPTEVVIVERTGSDGNTFQQLPFALAPGPP FT VPTTALRESIESTAAAVASGSPQLPSTALMDVLLRRPPRTRSGAALPRSSDPVTDIAAA FT ALDLDSSYLAVHGPPGTGKTYTAARVIAELVTEHAWRIGVVAQSHATVENLLEGVISAG FT LDPGQVAKKPHDHTAGRWQSIDGSQYTEFIRDTAGCVIGGTAWDFANGNRVPKASLDLL FT VIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPEPVDTSALSWLVDGQHTL FT PDERGYFLDRSYRMHPAVCAAVSALSYEGRLCSHTERTAVRRLDGYPPGVHTRGVHHKG FT NSIESPEEAEAILAELRQLLGSPWTDEHGTRPLAASDVLVLAPYNAQVALVRRRLASAG FT LGGADGVRVGTVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAA FT VIVRSELLTQYLPATPDGLVDLGAFLGLTSTS" FT CDS complement(85940..86548) FT /transl_table=11 FT /gene="lprE" FT /locus_tag="Mb1284c" FT /product="PROBABLE LIPOPROTEIN LPRE" FT /note="Mb1284c, lprE, len: 202 aa. Equivalent to Rv1252c, FT len: 202 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 202 aa overlap). Probable lipoprotein FT lprE, some similarity to Mycobacterium tuberculosis protein FT Rv3483c|MTCY13E12.36C (220 aa), FASTA scores: E(): 7e-05, FT (29.5% identity in 200 aa overlap). Contains possible FT N-terminal signal sequence and appropriately positioned FT prokaryotic lipoprotein lipid attachment site (PS00013)." FT /db_xref="GOA:P65313" FT /db_xref="UniProtKB/Swiss-Prot:P65313" FT /protein_id="CAD94145.1" FT /translation="MPGVWSPPCPTTPRVGVVAALVAATLTGCGSGDSTVAKTPEATPS FT LSTAHPAPPSSEPSPPSATAAPPSNHSAAPVDPCAVNLASPTIAKVVSELPRDPRSEQP FT WNPEPLAGNYNECAQLSAVVIKANTNAGNPTTRAVMFHLGKYIPQGVPDTYGFTGIDTS FT QCTGDTVALTYASGIGLNNVVKFRWNGGGVELIGNTTGG" FT CDS 86614..88305 FT /transl_table=11 FT /gene="deaD" FT /locus_tag="Mb1285" FT /product="PROBABLE COLD-SHOCK DEAD-BOX PROTEIN A HOMOLOG FT DEAD (ATP-dependent RNA helicase deaD homolog)" FT /note="Mb1285, deaD, len: 563 aa. Equivalent to Rv1253, FT len: 563 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 563 aa overlap). Probable Dead, FT Cold-shock DEAD-box protein A homolog, similar to many e.g. FT DEAD_ECOLI|P23304 Escherichia coli (646 aa), FASTA scores: FT opt: 1490, E(): 0, (46.7% identity in 578 aa overlap); FT similar to Mycobacterium tuberculosis Rv3211. Contains FT PS00017 ATP/GTP-binding site motif A, PS00039 DEAD-box FT subfamily ATP-dependent helicases signature. BELONGS TO THE FT DEAD BOX FAMILY HELICASE." FT /db_xref="GOA:Q7U0A2" FT /db_xref="HSSP:1HV8" FT /db_xref="InterPro:IPR014001" FT /db_xref="UniProtKB/TrEMBL:Q7U0A2" FT /protein_id="CAD94146.1" FT /translation="MAFPEYSPAASAATFADLQIHPRVLRAIGDVGYESPTAIQAATIP FT ALMAGSDVVGLAQTGTGKTAAFAIPMLSKIDITSKVPQALVLVPTRELALQVAEAFGRY FT GAYLSQLNVLPIYGGSSYAVQLAGLRRGAQVVVGTPGRVIDHLERATLDLSRVDFLVLD FT EADEMLTMGFADDVERILSETPEYKQVALFSATMPPAIRKLSAKYLHDPFEVTCKAKTA FT VAENISQSYIQVARKMDALTRVLEVEPFEAMIVFVRTKQATEEIAEKLRARGFSAAAIS FT GDVPQAQRERTITALRDGDIDILVATDVAARGLDVERISHVLNYDIPHDTESYVHRIGR FT TGRAGRSGAALIFVSPRELHLLKAIEKATRQTLTEAQLPTVEDVNTQRVAKFADSITNA FT LGGPGIELFRRLVEEYEREHDVPMADIAAALAVQCRGGEAFLMAPDPPLSRRNRDQRRD FT RPQRPKRRPDLTTYRVAVGKRHKIGPGAIVGAIANEGGLHRSDFGQIRIGPDFSLVELP FT AKLPRATLKKLAQTRISGVLIDLRPYRPPDAARRHNGGKPRRKHVG" FT CDS 88302..89453 FT /transl_table=11 FT /gene="Mb1286" FT /locus_tag="Mb1286" FT /product="PROBABLE ACYLTRANSFERASE" FT /EC_number="2.3.1.-" FT /note="Mb1286, -, len: 383 aa. Equivalent to Rv1254, len: FT 383 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 383 aa overlap). Probable Acyltransferase (EC FT 2.3.1.-), similar to G927228 midecamycin 4-0-propionyl FT transferase (fragment) (388 aa), FASTA scores, opt: 305, FT E(): 5.6e-14, (28.4% identity in 377 aa overlap). Also FT similar to other Mycobacterium tuberculosis FT acyltransferases e.g. Rv0111, Rv0228, etc. Contains PS00881 FT Protein splicing signature." FT /db_xref="GOA:Q7U0A1" FT /db_xref="InterPro:IPR002656" FT /db_xref="UniProtKB/TrEMBL:Q7U0A1" FT /protein_id="CAD94147.1" FT /translation="MTLPKERAAQGGLERIAHVDRVASLTGIRAVAALLVVGTHAAYTT FT GKYTHGYWGLMSSRMEIGVPIFFVLSGFLLFRPWVKSAATGGPPPSLSRYAWHRVRRIM FT PAYTVTVLLAYLVYHFRTAGPNPGHTWVGLFRNLTLTQIYTDGYLGAFLHQGLTQMWSL FT AVEVAFYLALPALAYLLLVLVCRRRWQPRLLLATMAGLTMISPAWLILVHNTHWMPDGA FT RLWLPTYLAWFVGGMMLAVLAAMGVRCYAFVAIPLAVICYFIVSTPIAGAPTTSPTALA FT EALVKTAFYAVIAVLAVAPLALGDQGWYAQLLASRPMVFLGEISYEIFLIHLVTMEIAM FT VDVLGYRVYTSSMVNLCLVTLVLTIPLAWLLHRFTRVQGDRPS" FT CDS complement(89422..89721) FT /transl_table=11 FT /gene="Mb1287c" FT /locus_tag="Mb1287c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1287c, -, len: 99 aa. Equivalent to 5' end of FT Rv1257c and 3' end of Rv1255c, len: 455 aa and 202 aa, from FT Mycobacterium tuberculosis strain H37Rv, (89.5% identity in FT 57 aa overlap and 83.6% identity in 67 aa overlap). FT Rv1257c: Probable oxidoreductase (EC 1.-.-.-), similar to FT e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 FT aa), FASTA scores: E(): 0, (38.9% identity in 458 aa FT overlap). Similar to Mycobacterium tuberculosis FT oxidoreductases e.g. Rv3107c. Rv1255c: Possible regulatory FT protein, similar to others e.g. ACRR_ECOLI|P34000 potential FT acrab operon repressor from E. coli (215 aa), FASTA scores: FT opt: 128, E(): 0.25, (42.1% identity in 57 aa overlap). FT Helix turn helix motif present at aa 36-57 (+5.48 SD). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT 3007 bp deletion (RD13) leads to the fusion of Rv1257c and FT Rv1255c, and the deletion of Rv1256c, compared to FT Mycobacterium tuberculosis strain H37Rv." FT /db_xref="UniProtKB/TrEMBL:Q7U0A0" FT /protein_id="CAD94148.1" FT /translation="MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAII FT RPRRARWVVRMLTSLLMFPGRDEADERAMIAEFVVPIVTPASAAARKAGHPGPE" FT CDS complement(89718..90977) FT /transl_table=11 FT /gene="Mb1288c" FT /locus_tag="Mb1288c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT FT PROTEIN" FT /note="Mb1288c, -, len: 419 aa. Equivalent to Rv1258c, len: FT 419 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 419 aa overlap). Probable conserved integral FT membrane transport (efflux) protein, possibly member of FT major facilitator superfamily (MFS), highly similar to FT O32859|TAP PROTEIN multidrug-resistance efflux pump from FT Mycobacterium fortuitum (409 aa), FASTA scores: E(): 0, FT (68.4% identity in 408 aa overlap). Contains PS00216 Sugar FT transport proteins signature 1." FT /db_xref="GOA:P64784" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/Swiss-Prot:P64784" FT /protein_id="CAD94149.1" FT /translation="MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQAS FT IVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVL FT VLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGL FT MIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNL FT RVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVL FT AIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRA FT AQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPA FT LRELDLAPQADIDRPVGSAQ" FT CDS 90976..91875 FT /transl_table=11 FT /gene="Mb1289" FT /locus_tag="Mb1289" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1289, -, len: 299 aa. Equivalent to Rv1259, len: FT 299 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 299 aa overlap). Conserved hypothetical FT protein. Similar to AL109732|SC7H2.04 hypothetical protein FT from Streptomyces coelicolor (237 aa), FASTA scores: opt: FT 870, E(): 0, (57.1% identity in 231 aa overlap)." FT /db_xref="InterPro:IPR005122" FT /db_xref="UniProtKB/Swiss-Prot:P64786" FT /protein_id="CAD94150.1" FT /translation="MNIAAESSAKPVWGPPNFCAAAARMQDVRVLMHPKTGRAFRSPVE FT PGSGWPGDPATPQTPVAADAAQVSALAGGAGSICELNALISVCRACPRLVSWREEVAVV FT KRRAFADQPYWGRPVPGWGSKRPRLLILGLAPAAHGANRTGRMFTGDRSGDQLYAALHR FT AGLVNSPVSVDAADGLRANRIRITAPVRCAPPGNSPTPAERLTCSPWLNAEWRLVSDHI FT RAIVALGGFAWQVALRLAGASGTPKPRFGHGVVTELGAGVRLLGCYHPSQQNMFTGRLT FT PTMLDDIFREAKKLAGIE" FT CDS 91877..92701 FT /transl_table=11 FT /gene="Mb1290" FT /locus_tag="Mb1290" FT /product="PROBABLE OXIDOREDUCTASE [FIRST PART]" FT /EC_number="1.-.-.-" FT /note="Mb1290, -, len: 274 aa. Equivalent to 5' end of FT Rv1260, len: 372 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.6% identity in 260 aa overlap). Probable FT oxidoreductase (EC 1.-.-.-), highly similar to FT E1245747|AL021411 putative oxidoreductase SC7H1.18 from FT Streptomyces coelicolor (397 aa), FASTA scores: E(): FT 1.4e-29, (45.9% identity in 355 aa overlap); also some FT similarity to G912582 FAD binding protein homologue from FT Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245, FT E(): 2e-09, (27.5% identity in 251 aa overlap); FT PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 FT aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity FT in 360 aa overlap); TETX_BACFR|Q01911 tetracycline FT resistance protein (388 aa), FASTA scores: opt: 183, E(): FT 3e-05, (22.8% identity in 373 aa overlap). Also similar to FT Mycobacterium tuberculosis hypothetical proteins Rv0575c FT and Rv1751. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1260 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT deletion (g-*) splits Rv1260 into 2 parts, Mb1290 and FT Mb1291." FT /db_xref="GOA:Q7U099" FT /db_xref="InterPro:IPR003042" FT /db_xref="UniProtKB/TrEMBL:Q7U099" FT /protein_id="CAD94151.1" FT /translation="MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV FT RGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTESTPTGGPVNSPDIELLR FT DDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFERAAAREFDLVIGADGLHSNVR FT RLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTEARAALA FT FMDTELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYIAAHRISISTKCRRS" FT CDS 92686..92994 FT /transl_table=11 FT /gene="Mb1291" FT /locus_tag="Mb1291" FT /product="PROBABLE OXIDOREDUCTASE [SECOND PART]" FT /EC_number="1.-.-.-" FT /note="Mb1291, -, len: 102 aa. Equivalent to 3' end of FT Rv1260, len: 372 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100% identity in 102 aa overlap). Probable FT oxidoreductase (EC 1.-.-.-), highly similar to FT E1245747|AL021411 putative oxidoreductase SC7H1.18 from FT Streptomyces coelicolor (397 aa), FASTA scores: E(): FT 1.4e-29, (45.9% identity in 355 aa overlap); also some FT similarity to G912582 FAD binding protein homologue from FT Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245, FT E(): 2e-09, (27.5% identity in 251 aa overlap); FT PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 FT aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity FT in 360 aa overlap); TETX_BACFR|Q01911 tetracycline FT resistance protein (388 aa), FASTA scores: opt: 183, E(): FT 3e-05, (22.8% identity in 373 aa overlap). Also similar to FT Mycobacterium tuberculosis hypothetical proteins Rv0575c FT and Rv1751. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1260 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT deletion (g-*) splits Rv1260 into 2 parts, Mb1290 and FT Mb1291." FT /db_xref="GOA:Q7U098" FT /db_xref="UniProtKB/TrEMBL:Q7U098" FT /protein_id="CAD94152.1" FT /translation="MSQILMDRWSRGRVALVGDAGYCCSPLSGQGTSVALLGAYILAGE FT LKAAGDDYQLGFANYHAEFHGFVERNQWLVSDNIPGGAPIPQEEFERIVHSITIKDY" FT CDS complement(93120..93569) FT /transl_table=11 FT /gene="Mb1292c" FT /locus_tag="Mb1292c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1292c, -, len: 149 aa. Equivalent to Rv1261c, len: FT 149 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 149 aa overlap). Conserved hypothetical FT protein, similar to Mycobacterium tuberculosis hypothetical FT proteins e.g. Rv1558|MTCY48.07c (39.2% identity in 125 aa FT overlap); Rv3547 and Rv3178." FT /db_xref="InterPro:IPR004378" FT /db_xref="UniProtKB/Swiss-Prot:P64788" FT /protein_id="CAD94153.1" FT /translation="MDISRWLERHVGVQLLRLHDAIYRGTNGRIGHRIPGAPPSLLLHT FT TGAKTSQPRTTSLTYARDGDAYLIVASKGGDPRSPGWYHNLKANPDVEINVGPKRFGVT FT AKPVQPHDPDYARLWQIVNENNANRYTNYQSRTSRPIPVVVLTRR" FT CDS complement(93574..94008) FT /transl_table=11 FT /gene="Mb1293c" FT /locus_tag="Mb1293c" FT /product="HYPOTHETICAL HIT-LIKE PROTEIN" FT /note="Mb1293c, -, len: 144 aa. Equivalent to Rv1262c, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 144 aa overlap). Hypothetical HIT-like FT protein, similar to Q04344|HIT_YEAST hit1 protein (orf u) FT (144 aa), FASTA scores: opt: 306, E(): 3e-14, (35.9 % FT identity in 142 aa overlap); also similar to FT YHIT_MYCGE|P47378 hypothetical 15.6 kd protein (141 aa), FT FASTA scores: opt: 250, E(): 1.6e-10, (35.5% identity in FT 107 aa overlap); and YHIT_MYCLE|P49774 hypothetical 17.0 kd FT protein hit-like (155 aa), FASTA scores: opt: 196, E(): FT 7e-07, (30.6% identity in 144 aa overlap). Similar to other FT proteins from Mycobacterium tuberculosis e.g. Rv2613c, FT Rv0759c. Contains PS00892 HIT family signature. BELONGS TO FT THE HIT FAMILY." FT /db_xref="GOA:Q7U097" FT /db_xref="HSSP:1EMS" FT /db_xref="InterPro:IPR019808" FT /db_xref="UniProtKB/TrEMBL:Q7U097" FT /protein_id="CAD94154.1" FT /translation="MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRH FT TVDLTDTPPEALADMVAIGQRIARAARATKLADATHIAINDGRAAFQTVFHVHLHVLPR FT RNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD" FT CDS 94067..95455 FT /transl_table=11 FT /gene="amiB2" FT /locus_tag="Mb1294" FT /product="PROBABLE AMIDASE AMIB2 (AMINOHYDROLASE)" FT /EC_number="3.5.1.4" FT /note="Mb1294, amiB2, len: 462 aa. Equivalent to Rv1263, FT len: 462 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 462 aa overlap). Probable amiB2, amidase FT (EC 3.5.1.4). Similar to G1001278 hypothetical 54.3 kDa FT protein (506 aa), FASTA scores: opt: 767, E(): 7.6e-40, FT (32.8% identity in 461 aa overlap), also similar to G580673 FT rhodococcus enantiose lective amidase gene (462 aa), FASTA FT scores, opt: 668, E(): 7.4e-34, (33.5% identity in 484 aa FT overlap); and to NYLA_PSES8|P13398 FT 6-aminohexanoate-cyclic-dimer hydrolase (492 aa), FASTA FT scores opt: 543, E(): 3.1e-26, (33.5% identity in 493 aa FT overlap). Also similar to MTCY274.19c (33.5% identity in FT 427 aa overlap). Similar to other putative amidases in M. FT tuberculosis e.g. Rv2363, Rv2888c, etc. Contains PS00017 FT ATP/GTP-binding site motif A. BELONGS TO THE AMIDASE FT FAMILY." FT /db_xref="GOA:P63493" FT /db_xref="HSSP:1M21" FT /db_xref="InterPro:IPR000120" FT /db_xref="UniProtKB/Swiss-Prot:P63493" FT /protein_id="CAD94155.1" FT /translation="MDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERLDSHLRA FT YRVVQFDRARAEAEAAQQRLDAGERLPLLGVPIAIKDDVDIAGEVTTYGSAGHGPAATS FT DAEVVRRLRAAGAVIIGKTNVPELMIMPFTESLAFGATRNPWCLNRTPGGSSGGSAAAV FT AAGLAPVALGSDGGGSIRIPCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIARSVM FT DAALLLDATTTVPGPEGEFVAAAARQPGRLRIALSTRVPTPLPVRCGKQELAAVHQAGA FT LLRDLGHDVVVRDPDYPASTYANYLPRFFRGISDDADAQAHPDRLEARTRAIARLGSFF FT SDRRMAALRAAEVVLSSRIQSIFDDVDVVVTPGAATGPSRIGAYQRRGAVSTLLLVVQR FT VPYFQVWNLTGQPAAVVPWDFDGDGLPMSVQLVGRPYDEATLLALAAQIESARPWAHRR FT PSVS" FT CDS 95530..96723 FT /transl_table=11 FT /gene="Mb1295" FT /locus_tag="Mb1295" FT /product="ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) FT (ADENYLATE CYCLASE)" FT /EC_number="4.6.1.1" FT /note="Mb1295, -, len: 397 aa. Equivalent to Rv1264, len: FT 397 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 397 aa overlap). Adenylate cyclase (EC FT 4.6.1.1) (function proven experimentally: see first FT citation below), showing some similarity to other adenylate FT cyclases e.g. CYAA_BRELI|P27580 (403 aa), FASTA scores, FT opt: 270, E(): 1.3e-10, (29.3% identity in 317 aa overlap); FT etc. Similar to other putative cyclases in M. tuberculosis FT e.g. Rv2212, Rv1647. BELONG TO THE ADENYLYL CYCLASE FT CLASS-4/GUANYLYL CYCLASE FAMILY. The C terminus seems to FT code for a catalytic domain belonging to a subfamily of FT adenylyl cyclase isozymes (mostly found in Gram-positive FT bacteria). The N terminus seems to be a potential novel FT regulator of adenylyl cyclase activity (autoinhibitory FT domain)." FT /db_xref="GOA:Q7U096" FT /db_xref="InterPro:IPR001054" FT /db_xref="UniProtKB/TrEMBL:Q7U096" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94156.1" FT /translation="MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEI FT RATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHM FT RADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDI FT AKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGECAAGKPLPGARQVTVAFAD FT LVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTV FT LKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVR FT EALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP" FT CDS 96896..97576 FT /transl_table=11 FT /gene="Mb1296" FT /locus_tag="Mb1296" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1296, -, len: 226 aa. Equivalent to Rv1265, len: FT 226 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 226 aa overlap). Hypothetical unknown protein FT (see citation below)." FT /db_xref="UniProtKB/Swiss-Prot:P64790" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94157.1" FT /translation="MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHG FT RRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPE FT EESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMT FT RLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGP FT DLPA" FT CDS complement(97596..99386) FT /transl_table=11 FT /gene="pknH" FT /locus_tag="Mb1297c" FT /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN FT KINASE H PKNH (PROTEIN KINASE H) (STPK H)" FT /EC_number="2.7.1.-" FT /note="Mb1297c, pknH, len: 596 aa. Similar to Rv1266c, len: FT 626 aa, from Mycobacterium tuberculosis strain H37Rv, FT (93.0% identity in 627 aa overlap). Probable pknH, FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-) FT (see citation below), similar to many e.g. FT PKN1_MYXXA|P33973 pkn1 (693 aa), FASTA scores: opt: 611, FT E(): 1.4e- 14, (29.7% identity in 492 aa overlap); etc. FT Contains PS00107 Protein kinases ATP-binding region FT signature; PS00108 Serine/Threonine protein kinases FT active-site signature. Contains Hank's kinase subdomain. FT BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. FT Experimental studies show evidence of auto-phosphorylation. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the FT pknH gene contains several substitutions, transitions and FT transversions compared to Mycobacterium tuberculosis strain FT H37Rv. The most significant difference results from a 127 FT bp to 24 bp substitution that leads to a shorter product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (596 aa versus 626 aa)." FT /db_xref="GOA:Q7U095" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:Q7U095" FT /protein_id="CAD94158.1" FT /translation="MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVK FT LMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSV FT LKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGIASA FT TTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRADSAGT FT LVSSHLMGPIPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQ FT DHAADILRRSQESTLPGTAAVTAQPPTMPTVTPPPIQAAPTGQPSWAPNSGPMPASGPT FT PTPQYYQGGGWGAPPSGGPSPWAQTPRKTNPWPLVAGAAAVVLVLVLGAIGIWIANRPK FT PVQPPQPVAEERLSALLLNSSEVNAVMGSSSMQPGKPITSMDSSPVTVSLPDCQGALYT FT SQDPVYAGTGYTAINGLISSEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG FT KTVTVTNKAKTYRWTFADVKGSPPTITVIDTQEGAEGWECQRAMSVANNVVVDVNACGY FT QITNQAGQIAAKIVDKVNKE" FT CDS complement(99727..100893) FT /transl_table=11 FT /gene="embR" FT /locus_tag="Mb1298c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR" FT /note="Mb1298c, embR, len: 388 aa. Equivalent to Rv1267c, FT len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 388 aa overlap). Probable embR, FT regulatory protein (see citation below), similar to many FT e.g. AFSR_STRCO|P25941 regulatory protein AfsR from FT Streptomyces coelicolor (993 aa), FASTA scores: opt: 489, FT E(): 1e-25, (33.5% identity in 361 aa overlap); etc. FT BELONGS TO THE AFSR/DNRI/REDD FAMILY OF REGULATORS." FT /db_xref="GOA:P66800" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P66800" FT /protein_id="CAD94159.1" FT /translation="MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVIN FT RNRPVGVDALITALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLS FT IPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFA FT TALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQS FT DALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRT FT MASGQQAVAYLHDIASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYV FT INDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT" FT CDS complement(101204..101902) FT /transl_table=11 FT /gene="Mb1299c" FT /locus_tag="Mb1299c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1299c, -, len: 232 aa. Equivalent to Rv1268c, len: FT 232 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 232 aa overlap). Hypothetical unknown protein, FT probably secreted protein : contains possible signal FT peptide sequence (score 7.9 at residue 28)." FT /db_xref="UniProtKB/Swiss-Prot:P64792" FT /protein_id="CAD94160.1" FT /translation="MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAAA FT KYWRQQTYDDCVLMSAADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAEHP FT NSGMGTSVADIPTLLAHYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSINAE FT MIWGQPVEETDSAGNPRSDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFVEAWA FT TSHDFMAVTT" FT CDS complement(102125..102499) FT /transl_table=11 FT /gene="Mb1300c" FT /locus_tag="Mb1300c" FT /product="CONSERVED PROBABLE SECRETED PROTEIN" FT /note="Mb1300c, -, len: 124 aa. Equivalent to Rv1269c, len: FT 124 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 124 aa overlap). Conserved probable exported FT protein with putative N-terminal signal sequence. Similar FT to Mycobacterium tuberculosis protein FT Rv1813c|Y0DU_MYCTU|Q50620 hypothetical protein cy1a11.30 FT (137 aa), FASTA scores: E(): 9e-21, (41.6% identity in 137 FT aa overlap)." FT /db_xref="InterPro:IPR017909" FT /db_xref="UniProtKB/Swiss-Prot:P0A5E2" FT /protein_id="CAD94161.1" FT /translation="MTTMITLRRRFAVAVAGVATAAATTVTLAPAPANAADVYGAIAYS FT GNGSWGRSWDYPTRAAAEATAVKSCGYSDCKVLTSFTACGAVAANDRAYQGGVGPTLAA FT AMKDALTKLGGGYIDTWACN" FT CDS complement(102560..103294) FT /transl_table=11 FT /gene="lprA" FT /locus_tag="Mb1301c" FT /product="PUTATIVE LIPOPROTEIN LPRA" FT /note="Mb1301c, lprA, len: 244 aa. Equivalent to Rv1270c, FT len: 244 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 244 aa overlap). Putative lipoprotein FT lprA (Precursor). Similar to O32852|AJ000500 lipoprotein FT from Mycobacterium bovis (236 aa), fasta scores: E(): FT 5.2e-23, (35.1% identity in 245 aa overlap). Similar to M. FT tuberculosis lipoproteins: Rv1368, Rv1411c, Rv2945c. FT Contains probable N-terminal signal sequence." FT /db_xref="GOA:Q7U094" FT /db_xref="InterPro:IPR009830" FT /db_xref="UniProtKB/Swiss-Prot:Q7U094" FT /protein_id="CAD94162.1" FT /translation="MKHPPCSVVAAATAILAVVLAIGGCSTEGDAGKASDTAATASNGD FT AAMLLKQATDAMRKVTGMHVRLAVTGDVPNLRVTKLEGDISNTPQTVATGSATLLVGNK FT SEDAKFVYVDGHLYSDLGQPGTYTDFGNGTSIYNVSVLLDPNKGLANLLANLKDASVAG FT SQQADGVATTKITGNSSADDIATLAGSRLTSEDVKTVPTTVWIASDGSSHLVQIQIAPT FT KDTSVTLTMSDWGKQVTATKPV" FT CDS complement(103507..103848) FT /transl_table=11 FT /gene="Mb1302c" FT /locus_tag="Mb1302c" FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN" FT /note="Mb1302c, -, len: 113 aa. Equivalent to Rv1271c, len: FT 113 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 113 aa overlap). Conserved hypothetical FT exported protein with potential N-terminal signal sequence. FT Similar to Mycobacterium tuberculosis hypothetical proteins FT Rv1804c, Rv1810, Rv0622, etc." FT /db_xref="InterPro:IPR007969" FT /db_xref="UniProtKB/Swiss-Prot:P64794" FT /protein_id="CAD94163.1" FT /translation="MLSPLSPRIIAAFTTAVGAAAIGLAVATAGTAGANTKDEAFIAQM FT ESIGVTFSSPQVATQQAQLVCKKLASGETGTEIAEEVLSQTNLTTKQAAYFVVDATKAY FT CPQYASQLT" FT CDS complement(103956..105851) FT /transl_table=11 FT /gene="Mb1303c" FT /locus_tag="Mb1303c" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /note="Mb1303c, -, len: 631 aa. Equivalent to Rv1272c, len: FT 631 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 631 aa overlap). Probable drugs-transport FT transmembrane ATP-binding protein ABC transporter (see FT citation below), similar to e.g. Y015_MYCGE|P47261 FT hypothetical ABC transporter mg015m from Mycoplasma FT genitalium (589 aa), FASTA scores: opt: 1054, E(): 0, FT (34.3% identity in 522 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop); and PS00211 ABC FT transporters family signature. BELONGS TO THE ATP-BINDING FT TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), MSBA FT SUBFAMILY." FT /db_xref="GOA:P63398" FT /db_xref="HSSP:1MT0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P63398" FT /protein_id="CAD94164.1" FT /translation="MTAPPGARPRAASPPPNMRSRDFWGSAARLVKRLAPQRRLSIAVI FT TLGIAGTTIGVIVPRILGHATDLLFNGVIGRGLPGGITKAQAVASARARGDNTFADLLS FT GMNVVPGQGVDFAAVERTLALALALYLAAALMIWAQARLLNLTVQKTMVRLRTDVEDKV FT HRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTISQLVTSILTMVAVLAMMVSISGLL FT ALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLNAHLEETYSGFTVVKTFGHQAAA FT RERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYVAVAVAGGLQVATGQITLGSIQ FT AFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDEPEESPEPEPELPNLTGRVEF FT EHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTGAGKTTLVNLLMRFYEIGSGRILIDG FT VDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGRPEATTDEIVEAARAAHVDRFVN FT TLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLLILDEATSSVDTRTELLIQRAM FT RELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNHAELLARRGVYYQMTRA" FT CDS complement(105848..107596) FT /transl_table=11 FT /gene="Mb1304c" FT /locus_tag="Mb1304c" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /note="Mb1304c, -, len: 582 aa. Equivalent to Rv1273c, len: FT 582 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 582 aa overlap). Probable drug-transport FT transmembrane ATP-binding protein ABC transporter (see FT citation below), similar to e.g. YWJA_BACSU|P45861 FT hypothetical abc transporter from Bacillus subtilis (575 FT aa), FASTA scores: opt: 810, E(): 0, (27.0% identity in 578 FT aa overlap); etc. Contains PS00136 Serine proteases, FT subtilase family, aspartic acid active site; 2 x PS00211 FT ABC transporters family signature; and PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), FT MSBA SUBFAMILY." FT /db_xref="GOA:P0A4W5" FT /db_xref="HSSP:1JJ7" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P0A4W5" FT /protein_id="CAD94165.1" FT /translation="MLLALLRQHIRPYRRLVAMLMMLQLVSTLASLYLPTVNAAIVDDG FT VAKGDTATIVRLGAVMLGVTGLQVLCAIGAVYLGSRTGAGFGRDLRSAMFEHIITFSER FT ETARFGAPTLLTRSTNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWLLLV FT SVPILAVANYWIISHMLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERDKFAQ FT ANTALSNAALSAGNWQALMLPVTTLTINASSVALIWFGGLRIDSGQMQVGSLIAFLSYF FT AQILMAVLMATMTLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGVVRLAGA FT TFTYPGADCPVLQDISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGAVLVDGID FT VREYHTERLWSAIGLVPQRSYLFSGTVADNLRYGGGPDQVVTEQEMWEALRVAAADGFV FT QTDGLQTRVAQGGVNFSGGQRQRLAIARAVIRRPAIYVFDDAFSALDVHTDAKVHASLR FT QVSGDATIIVVTQRISNAAQADQVIVVDNGKIVGTGTHETLLADCPTYAEFAASQSLSA FT TVGGVG" FT CDS 107743..108300 FT /transl_table=11 FT /gene="lprB" FT /locus_tag="Mb1305" FT /product="PUTATIVE LIPOPROTEIN LPRB" FT /note="Mb1305, lprB, len: 185 aa. Equivalent to Rv1274, FT len: 185 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 185 aa overlap). Possible lipoprotein FT lprB, contains possible N-terminal signal sequence and FT appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013) . Some similarity to Rv1275." FT /db_xref="GOA:Q7U093" FT /db_xref="UniProtKB/Swiss-Prot:Q7U093" FT /protein_id="CAD94166.1" FT /translation="MRRKVRRLTLAVSALVALFPAVAGCSDSGDNKPGATIPSTPANAE FT GRHGPFFPQCGGVSDQTVTELTRVTGLVNTAKNSVGCQWLAGGGILGPHFSFSWYRGSP FT IGRERKTEELSRASVEDINIDGHSGFIAIGNEPSLGDSLCEVGIQFSDDFIEWSVSFSQ FT KPFPPPCDIAKELTRQSIANSK" FT CDS 108297..108839 FT /transl_table=11 FT /gene="lprC" FT /locus_tag="Mb1306" FT /product="PUTATIVE LIPOPROTEIN LPRC" FT /note="Mb1306, lprC, len: 180 aa. Equivalent to Rv1275, FT len: 180 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 180 aa overlap). Possible lipoprotein FT lprC, contains possible N-terminal signal sequence and FT appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013). Some similarity to Rv1274." FT /db_xref="UniProtKB/TrEMBL:Q7U092" FT /protein_id="CAD94167.1" FT /translation="MRRVLVGAAALITALLVLTGCTKSISGTAVKAGGAGVPRNNNSQE FT RYPNLLKECEVLTTDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGS FT LSNERKVAEGLKYQVETRAIQGVDSIVMRTGDPNGACGVASDAAGVVGWWVNPQAPGID FT ACGQAIKLMELTLATNA" FT CDS complement(108984..109460) FT /transl_table=11 FT /gene="Mb1307c" FT /locus_tag="Mb1307c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1307c, -, len: 158 aa. Equivalent to Rv1276c, len: FT 158 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 158 aa overlap). Conserved hypothetical FT protein, similar to AL096844|SCI28.03 hypothetical protein FT from Streptomyces coelicolor (172 aa), FASTA scores: opt: FT 385, E(): 3.3e-19, (43.5% identity in 161 aa overlap). Some FT similarity to P76502|SIXA_ECOLI PHOSPHOHISTIDINE FT PHOSPHATASE SIXA (161 aa), FASTA scores: opt: 146, E(): FT 0.0047, (31.9% identity in 116 aa overlap). BELONGS TO THE FT SIXA FAMILY OF PHOSPHATASES." FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/TrEMBL:Q7U091" FT /protein_id="CAD94168.1" FT /translation="MRHAKSAYPDGIADHDRPLAPRGIREAGLAGGWLRANLPAVDAVL FT CSTATRARQTLAHTGIDAPARYAERLYGAAPGTVIEEINRVGDNVTSLLVVGHEPTTSA FT LAIVLASISGTDAAVAERISEKFPTSGIAVLRVAGHWADVEPGCAALVGFHVPR" FT CDS 109710..110963 FT /transl_table=11 FT /gene="Mb1308" FT /locus_tag="Mb1308" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1308, -, len: 417 aa. Equivalent to Rv1277, len: FT 417 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 417 aa overlap). Conserved hypothetical FT protein, some similarity to 3914967|O68033|SBCD_RHOCA FT EXONUCLEASE SBCD HOMOLOG from Rhodobacter capsulatus (405 FT aa). May be sbcD protein (see first citation below)" FT /db_xref="GOA:Q7U090" FT /db_xref="InterPro:IPR014577" FT /db_xref="UniProtKB/TrEMBL:Q7U090" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94169.1" FT /translation="MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQL FT GMTRHFLAGDAQPRYSAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQSL FT EAMRVIGLPVYLLPGNHDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQIVAA FT PWRSKAPTTDPVAEVLAGLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDALTRQ FT AIHYVALGDKHSLTQVGSSGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPRHPVTV FT DARRIGRWRFVTLHHQVDTSRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTDRAALDT FT CLDKYARLFAWLGLWERHTDLAVIPVDAEFTDLGIGGFAAAAVDELVATARGGDDESAV FT DAQAALALLLRLADRGAA" FT CDS 110960..113587 FT /transl_table=11 FT /gene="Mb1309" FT /locus_tag="Mb1309" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1309, -, len: 875 aa. Equivalent to Rv1278, len: FT 875 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 875 aa overlap). Hypothetical unknown protein, FT possible coiled-coil regions, contains PS00017 FT ATP/GTP-binding site motif A." FT /db_xref="UniProtKB/Swiss-Prot:P64796" FT /protein_id="CAD94170.1" FT /translation="MKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEALD FT LLLEYKDRSTKKEVKQVKPTNADVGSEVIAEISSGPYRFVYRKRFHKRCETELTVLAPR FT REQLTGDEAHERVRTMLAETVDTELWHAQRVLQAASTAAVDLSGCDALSRALDLAAGDD FT AALSGTESLLIERIEAEYARYFTPTGRPTGEWSAAVSRLAAAEAAVADCAAAVAEVDDG FT VRRHTELTEQVAELSQQLLAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAATSGAS FT TAAHAGRLGLLTEIDTRTAAVVAAEAKARQAADEQATARAEAEACDAALTEATQVLTAV FT RLRAESARRTLDQLADCEEADRLAARLARIDDIEGDRDRVCAELSAVTLTEELLSRIER FT AAAAVDRGGAQLASISAAVEFTAAVDIELGVGDQRVSLSAGQSWSVTATGPTEVKVPGV FT LTARIVPGATALDFQAKYAAAQQELADALAAGEVADLAAARSADLCRRELLSRRDQLTA FT TLAGLCGDEQVDQLRSRLEQLCAGQPAELDLVSTDTATARAELDAVEAARIAAEKDCET FT RRQIAAGAARRLAETSTRATVLQNAAAAESAELGAAMTRLACERASVGDDELAAKAEAD FT LRVLQTAEQRVIDLADELAATAPDAVAAELAEAADAVELLRERHDEAIRALHEVGVELS FT VFGTQGRKGKLDAAETEREHAASHHARVGRRARAARLLRSVMARHRDTTRLRYVEPYRA FT ELHRLGRPVFGPSFEVEVDTDLRIRSRTLDDRTVPYECLSGGAKEQLGILARLAGAALV FT AKEDAVPVLIDDALGFTDPERLAKMGEVFDTIGADGQVIVLTCSPTRYGGVKGAHRIDL FT DAIQ" FT CDS 113608..115194 FT /transl_table=11 FT /gene="Mb1310" FT /locus_tag="Mb1310" FT /product="PROBABLE DEHYDROGENASE FAD flavoprotein GMC FT oxidoreductase" FT /EC_number="1.1.-.-" FT /note="Mb1310, -, len: 528 aa. Equivalent to Rv1279, len: FT 528 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 528 aa overlap). Probable dehydrogenase, FAD FT flavoprotein GMC oxidoreductase (EC 1.1.-.-), similar to FT several e.g. dBETA_ECOLI|P17444 choline dehydrogenase from FT Escherichia coli (556 aa), FASTA scores, opt: 1047, E(): 0, FT (37.7% identity in 541 aa overlap). Similar to Rv0697 FT putative Mycobacterium tuberculosis GMC oxidoreductase. FT Contains PS00623 GMC oxidoreductases signature 1, and FT PS00624 GMC oxidoreductases signature 2. BELONGS TO THE GMC FT OXIDOREDUCTASES FAMILY." FT /db_xref="GOA:P64264" FT /db_xref="InterPro:IPR007867" FT /db_xref="UniProtKB/Swiss-Prot:P64264" FT /protein_id="CAD94171.1" FT /translation="MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFI FT GVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVRGFASDYD FT EWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWL FT AAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATAT FT RVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDID FT TVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNVGEAYGF FT VRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAK FT PVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELA FT LATCSHTLYHPMGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVL FT IGEKAADLIRS" FT CDS complement(115211..116986) FT /transl_table=11 FT /gene="oppA" FT /locus_tag="Mb1311c" FT /product="PROBABLE PERIPLASMIC OLIGOPEPTIDE-BINDING FT LIPOPROTEIN OPPA" FT /note="Mb1311c, oppA, len: 591 aa. Equivalent to Rv1280c, FT len: 591 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 591 aa overlap). Probable oppA, FT oligopeptide-binding lipoprotein component of peptide FT transport system (see citation below), sharing some FT similarity to other periplasmic solute binding proteins FT e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding FT protein from Salmonella typhimurium (542 aa), FASTA scores: FT E(): 5.1e-05, (22.1% identity in 458 aa overlap); etc. Also FT similar to Rv1166 and Rv2585c from Mycobacterium FT tuberculosis. Has possible N-terminal signal sequence and FT prokaryotic lipoprotein lipid attachment site (PS00013). FT BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING FT PROTEIN FAMILY 5." FT /db_xref="GOA:P66772" FT /db_xref="InterPro:IPR000914" FT /db_xref="UniProtKB/Swiss-Prot:P66772" FT /protein_id="CAD94172.1" FT /translation="MADRGQRRGCAPGIASALRASFQGKSRPWTQTRYWAFALLTPLVV FT AMVLTGCSASGTQLELAPTADRRAAVGTTSDINQQDPATLQDGGNLRLSLTDFPPNFNI FT LHIDGNNAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTRTAPQVVTYTINPEAV FT WSDGTPITWRDIASQIHAISGADKAFEIASSSGAERVASVTRGVDDRQAVVTFAKPYAE FT WRGMFAGNGMLLPASMTATPEAFNKGQLDGPGPSAGPFVVSALDRTAQRIVLTRNPRWW FT GARPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAARTKGISIRRAPGPSWY FT HFTLNGAPGSILADKALRLAIAKGIDRYTIARVAQYGLTSDPVPLNNHVFVAGQDGYQD FT NSGVVAYNPEQAKRELDALGWRRSGAFREKDGRQLVIRDLFYDAQSTRQFAQIAQHTLA FT QIGVKLELQAKSGSGFFSDYVNVGAFDIAQFGWVGDAFPLSSLTQIYASDGESNFGKIG FT SPQIDAAIERTLAELDPGKARALANQVDELIWAEGFSLPLTQSPGTVAVRSTLANFGAT FT GLADLDYTAIGFMRR" FT CDS complement(116979..118817) FT /transl_table=11 FT /gene="oppD" FT /locus_tag="Mb1312c" FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT ATP-BINDING FT PROTEIN ABC TRANSPORTER OPPD" FT /note="Mb1312c, oppD, len: 612 aa. Equivalent to Rv1281c, FT len: 612 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 612 aa overlap). Probable oppD, FT oligopeptide-transport ATP-binding protein ABC transporter FT (see citation below), similar to others e.g. FT DPPD_BACSU|P26905 dipeptide transport ATP-binding protein FT from Bacillus subtilis (335 aa), FASTA scores: opt: 983, FT E(): 0, (48.6% identity in 319 aa overlap); etc. Contains 2 FT x PS00017 ATP/GTP-binding site motif A (P-loop); 2 x FT PS00211 ABC transporters family signature. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:P63396" FT /db_xref="HSSP:1B0U" FT /db_xref="InterPro:IPR013563" FT /db_xref="UniProtKB/Swiss-Prot:P63396" FT /protein_id="CAD94173.1" FT /translation="MSPLLEVTDLAVTFRTDGDPVTAVRGISYRVEPGEVVAMVGESGS FT GKSAAAMAVVGLLPEYAQVRGSVRLQGTELLGLADNAMSRFRGKAIGTVFQDPMSALTP FT VYTVGDQIAEAIEVHQPRVGKKAARRRAVELLDLVGISQPQRRSRAFPHELSGGERQRV FT VIAIAIANDPDLLICDEPTTALDVTVQAQILDVLKAARDVTGAGVLIITHDLGVVAEFA FT DRALVMYAGRVVESAGVNDLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAG FT LAPGCPFAPRCPLVIDECLTAEPELLDVATDHRAACIRTELVTGRSAADIYRVKTEARP FT AALGDASVVVRVRHLVKTYRLAKGVVLRRAIGEVRAVDGISLELRQGRTLGIVGESGSG FT KSTTLHEILELAAPQSGSIEVLGTDVATLGTAERRSLRRDIQVVFQDPVASLDPRLPVF FT DLIAEPLQANGFGKNETHARVAELLDIVGLRHGDASRYPAEFSGGQKQRIGIARALALQ FT PKILALDEPVSALDVSIQAGIINLLLDLQEQFGLSYLFVSHDLSVVKHLAHQVAVMLAG FT TVVEQGDSEEVFGNPKHEYTRRLLGAVPQPDPARRG" FT CDS complement(118814..119689) FT /transl_table=11 FT /gene="oppC" FT /locus_tag="Mb1313c" FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER OPPC" FT /note="Mb1313c, oppC, len: 291 aa. Equivalent to Rv1282c, FT len: 291 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 291 aa overlap). Probable oppC, FT oligopeptide-transport integral membrane protein ABC FT transporter (see citation below), similar to other integral FT membrane proteins e.g. OPPC_ECOLI|P77664 oligopeptide FT transport system permease from Escherichia coli (302 aa), FT FASTA scores: E(): 4.6e-33, (40.7% identity in 275 aa FT overlap); etc. Also similar to Rv3664c|DPPC probable FT peptide-transport integral membrane protein from FT Mycobacterium tuberculosis." FT /db_xref="GOA:P66965" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/Swiss-Prot:P66965" FT /protein_id="CAD94174.1" FT /translation="MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPYS FT YDDLDFNALLQPPGTKHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATVGA FT ISGYFGGWRDRTLMWVVDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMISSR FT MVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILAETGL FT SFLGFGIQPPDVSLGTLIADGTASATAFPWVFLFPASILVLILVCANLTGDGLRDALDP FT ASRSLRRGVR" FT CDS complement(119686..120663) FT /transl_table=11 FT /gene="oppB" FT /locus_tag="Mb1314c" FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN ABC TRANSPORTER OPPB" FT /note="Mb1314c, oppB, len: 325 aa. Equivalent to Rv1283c, FT len: 325 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 325 aa overlap). Probable oppB, FT oligopeptide-transport integral membrane protein ABC FT transporter (see citation below), similar to other integral FT membrane proteins e.g. DPPB_ECOLI|P37316 dipeptide FT transport system permease protein from Escherichia coli FT (339 aa), FASTA scores: opt: 402, E(): 3.4e-20, (31.0% FT identity in 345 aa overlap); etc. Also similar to FT Rv3665c|DppB probable peptide-transport integral membrane FT protein from Mycobacterium tuberculosis. Contains PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp signature." FT /db_xref="GOA:P66967" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/Swiss-Prot:P66967" FT /protein_id="CAD94175.1" FT /translation="MTRYLARRLLNYLVLLALASFLTYCLTSLAFSPLESLMQRSPRPP FT QAVIDAKAHDLGLDRPILARYANWVSHAVRGDFGTTITGQPVGTELGRRIGVSLRLLVV FT GSVFGTVAGVVIGAWGAIRQYRLSDRVMTTLALLVLSTPTFVVANLLILGALRVNWAVG FT IQLFDYTGETSPGVAGGVWDRLGDRLQHLILPSLTLALAAAAGFSRYQRNAMLDVLGQD FT FIRTARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGAVFVEKIFGWHGMGEWM FT VRGISTQDTNIVAAITVFSGAVVLLAGLLSDVIYAALDPRVRVS" FT CDS 120870..121361 FT /transl_table=11 FT /gene="Mb1315" FT /locus_tag="Mb1315" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1315, -, len: 163 aa. Equivalent to Rv1284, len: FT 163 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 163 aa overlap). Conserved hypothetical FT protein, similar to AL109663|SC4A10.26 hypothetical protein FT from Streptomyces coelicolor (167 aa), FASTA scores: opt: FT 567, E(): 1.5e-32, (53.4% identity in 163 aa overla); shows FT some similarity to hypothetical protein from FT Methanobacterium thermoautotrophicum. Weak similarity to FT carbonic anhydrases e.g. U51624|MTU516242|P17582 FT Methanothermobacter thermautotrophicus (171 aa), FASTA FT score: opt: 305, E(): 1 .2e-14, (35.2% identity in 165 aa FT overlap)." FT /db_xref="GOA:P64798" FT /db_xref="HSSP:1G5C" FT /db_xref="InterPro:IPR001765" FT /db_xref="UniProtKB/Swiss-Prot:P64798" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94176.1" FT /translation="MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRM FT LGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRA FT IQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP FT " FT CDS 121455..122453 FT /transl_table=11 FT /gene="cysD" FT /locus_tag="Mb1316" FT /product="PROBABLE SULFATE ADENYLYLTRANSFERASE SUBUNIT 2 FT CYSD" FT /EC_number="2.7.7.4" FT /note="Mb1316, cysD, len: 332 aa. Equivalent to Rv1285, FT len: 332 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 332 aa overlap). Probable cysD, sulfate FT adenylyltransferase subunit 2 (EC 2.7.7.4) (see first FT citation below), homology suggests start site at aa 24 or FT 28, similar to e.g. CYSD_ECOLI|P21156 sulfate adenylate FT transferase subunit 2 from Escherichia coli (302 aa), FASTA FT score: opt: 973, E():0, (52.5% identity in 303 aa overlap). FT Also similar to Mycobacterium tuberculosis Rv2392, FT 3'-phosphoadenylylsulfate reductase. BELONGS TO THE PAPS FT REDUCTASE FAMILY. CYSD SUBFAMILY. Thought to be FT differentially expressed within host cells (see third FT citation below)." FT /db_xref="GOA:P65671" FT /db_xref="InterPro:IPR011784" FT /db_xref="UniProtKB/Swiss-Prot:P65671" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94177.1" FT /translation="MAITINMVNPTGFIRYEDVEQEAMTSDVTVGPAPGQYQLSHLRLL FT EAEAIHVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNFDE FT VIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDAAFG FT GARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEF FT DIWSYIGAEQVRLPSIYFAHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFRTVGDV FT TCTGCVESSASTVAEVIAETAVARLTERGATRADDRISEAGMEDRKRQGYF" FT CDS 122453..124297 FT /transl_table=11 FT /gene="cysN" FT /locus_tag="Mb1317" FT /product="PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC: SULFATE FT ADENYLTRANSFERASE (SUBUNIT 1) + ADENYLYLSULFATE KINASE" FT /EC_number="2.7.7.4" FT /EC_number="2.7.1.25" FT /note="Mb1317, cysN, len: 614 aa. Equivalent to Rv1286, FT len: 614 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 614 aa overlap). Probable cysN/cysC FT bifunctional enzyme, sulfate adenylyltransferase subunit 1 FT (EC 2.7.7.4) and Adenylylsulfate kinase (EC 2.7.1.25) (see FT first citation below), similar to CYSN_ECOLI|P23845 sulfate FT adenylate transferase subunit 1 from Escherichia coli (475 FT aa), FASTA scores: opt: 1291, E():0, (50.2% identity in 428 FT aa overlap). Contains 2 x PS00017 ATP/GTP-binding site FT motif A, PS00301 GTP-binding elongation factors signature." FT /db_xref="GOA:Q7U089" FT /db_xref="HSSP:1D6J" FT /db_xref="InterPro:IPR004161" FT /db_xref="UniProtKB/TrEMBL:Q7U089" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94178.1" FT /translation="MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVEQTSKD FT RGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGAS FT TAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVLAVNKMDLLGWDQEKFDAIRDEFH FT AFAARLDVQDVTSIPISALHGDNVVTKSDQTPWYEGPSLLSHLEDVYIAGDRNMVDVRF FT PVQYVIRPHTLEHQDHRSYAGTLASGVMRSGDEVVVLPIGKTTRITAIDGPNGPVAEAF FT PPMAVSVRLADDIDISRGDMIARTHNQPRITQEFDATVCWMADNAVLEPGRDYVVKHTT FT RTVRARIAGLDYRLDVNTLHRDKTATALKLNELGRVSLRTQVPLLLDEYTRNASTGSFI FT LIDPDTNGTVAAGMVLRDVSARTPSPNTVRHRSLVTAQDRPPRGKTVWFTGLSGSGKSS FT VAMLVERKLLEKGISAYVLDGDNLRHGLNADLGFSMADRAENLRRLSHVATLLADCGHL FT VLVPAISPLAEHRALARKVHADAGIDFFEVFCDTPLQDCERRDPKGLYAKARAGEITHF FT TGIDSPYQRPKNPDLRLTPDRSIDEQAQEVIDLLESSS" FT CDS 124351..124836 FT /transl_table=11 FT /gene="Mb1318" FT /locus_tag="Mb1318" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1318, -, len: 161 aa. Equivalent to Rv1287, len: FT 161 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 161 aa overlap). Conserved hypothetical FT protein, similar to VJEB family of proteins e.g. FASTA FT score: P44675|Y379_HAEIN HYPOTHETICAL PROTEIN HI0379 (150 FT aa), FASTA scores: opt: 213, E(): 2.5e-08, (30.0% identity FT in 130 aa overlap) and YJEB_ECOLI|P21498 hypothetical 15.6 FT kd protein in pura-vacb (141 aa), opt: 167, E(): 9.5e-06, FT (25.0% identity in 136 aa overlap). BELONGS TO THE UPF0074 FT (RFF2) FAMILY." FT /db_xref="GOA:P67160" FT /db_xref="InterPro:IPR000944" FT /db_xref="UniProtKB/Swiss-Prot:P67160" FT /protein_id="CAD94179.1" FT /translation="MRMSAKAEYAVRAMVQLATAASGTVVKTDDLAAAQGIPPQFLVDI FT LTNLRTDRLVRSHRGREGGYELARPGTEISIADVLRCIDGPLASVRDIGLGDLPYSGPT FT TALTDVWRALRASMRSVLEETTLADVAGGALPEHVAQLADDYRAQESTRHGASRHGD" FT CDS 124894..126111 FT /transl_table=11 FT /gene="Mb1319" FT /locus_tag="Mb1319" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1319, -, len: 405 aa. Similar to Rv1288, len: 456 FT aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% FT identity in 403 aa overlap). Conserved hypothetical FT protein, some similarity to A85B_MYCTU|P31952 antigen 85-b FT precursor (85b) (325 aa), FASTA scores: opt: 199, E(): FT 2.7e-06, (24.7% identity in 279 aa overlap). Also similar FT to Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (related to FT antigen 85 complex) from Corynebacterium glutamicum (657 FT aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity FT in 352 aa overlap). SEEMS TO CONTAIN 3 LYSM REPEATS. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT 153 bp deletion leads to a shorter product compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv (405 aa FT versus 456 aa)." FT /db_xref="GOA:Q7U088" FT /db_xref="InterPro:IPR000801" FT /db_xref="UniProtKB/TrEMBL:Q7U088" FT /protein_id="CAD94180.1" FT /translation="MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVG FT QRLIMPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIG FT RSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGG FT GTDQDFRTFDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLP FT WIEANFRTYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVH FT WANLSSAVLDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFD FT SVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGA FT AAERAD" FT CDS 126160..126792 FT /transl_table=11 FT /gene="Mb1320" FT /locus_tag="Mb1320" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1320, -, len: 210 aa. Equivalent to Rv1289, len: FT 210 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 210 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64800" FT /protein_id="CAD94181.1" FT /translation="MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLGV FT GTRFRTALRDSLDIYGVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWLHG FT HADESSVEFEVSPYVNASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPPDYQ FT LSWYDHVFFISVWWGWQDHFREIVNVDRASLVALDFGDLWNGWTPVG" FT CDS complement(126931..128496) FT /transl_table=11 FT /gene="Mb1321c" FT /locus_tag="Mb1321c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1321c, -, len: 521 aa. Equivalent to Rv1290c, len: FT 521 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 521 aa overlap). Conserved hypothetical FT protein, similar to AL031013|SC8A6.09 hypothetical protein FT from Streptomyces coelicolor (443 aa), FASTA scores: opt: FT 371, E(): 9.5e-17, (28.3% identity in 446 aa overlap)." FT /db_xref="GOA:P0A5E4" FT /db_xref="InterPro:IPR018723" FT /db_xref="UniProtKB/Swiss-Prot:P0A5E4" FT /protein_id="CAD94182.1" FT /translation="MLQRSLGVNGRKLAMSARSAKRERKNASTAASKCYVVPPSARGWV FT HAYSVTATSMLNRRKAILDYLQGAVWVLPTFGVAIGLGSGAVLSMIPVKSGTLIDKLMF FT QGTPGDARGVLIVVSATMITTIGIVFSLTVLSLQIASSQFSVRLLRTFLRDVPNQVVLA FT IFACTFAYSTGGLHTVGEHRDGGAFIPKVAVTGSLALAFVSIAALIYFLHHLMHSIQID FT TIMDKVRLRTLGLVDQLYPESDTADRQVETPPSPPADAVPLLAPHSGYLQTVDVDDIAE FT LAAASRYTALLVTFVGDYVTAGGLLGWCWRRGTAPGAPGSDFPQRCLRHVHIGFERTLQ FT QDIRFGLRQMVDIALRALSPALNDPYTAIQVVHHLSAVESVLASRALPDDVRRDRAGEL FT LFWLPYPSFATYLHVGCAQIRRYGSREPLVLTALLQLLSAVAQNCVDPSRRVAVQTQIA FT LVVRAAQREFADESDRAMVLGAAARATEVVERPGTLAPPPSTFGQVAAAQAAASTIRSA FT DRDG" FT CDS 128507..128821 FT /transl_table=11 FT /gene="Mb1322" FT /locus_tag="Mb1322" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1322, -, len: 104 aa. Equivalent to Rv1290A, len: FT 104 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 104 aa overlap). Hypothetical unknown protein, FT equivalent to AAK45590 from Mycobacterium tuberculosis FT strain CDC1551 (122 aa) but shorter 18 aa." FT /db_xref="UniProtKB/TrEMBL:Q7U087" FT /protein_id="CAD94183.1" FT /translation="MLALHGLSEGVSGSGGSGGRWGAGEVLEGARIGVIADGVSCFPTK FT ADCRRIRGVPVFDGYTRMVARLMGSLAVLRSVSIPKGYRDFGFGSLRAVAPKNCPDVSG FT " FT CDS complement(128948..129283) FT /transl_table=11 FT /gene="Mb1323c" FT /locus_tag="Mb1323c" FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN" FT /note="Mb1323c, -, len: 111 aa. Equivalent to Rv1291c, len: FT 111 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 111 aa overlap). Conserved hypothetical FT secreted protein, similar to others in Mycobacterium FT tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU HYPOTHETICAL FT 11.6 KD PROTEIN (113 aa), FASTA score: opt: 246, E(): FT 1.7e-09, (40.0% identity in 110 aa overlap); Rv1804c, FT Rv1810, Rv0622, etc." FT /db_xref="InterPro:IPR007969" FT /db_xref="UniProtKB/Swiss-Prot:P0A5E6" FT /protein_id="CAD94184.1" FT /translation="MFTRRFAASMVGTTLTAATLGLAALGFAGTASASSTDEAFLAQLQ FT ADGITPPSAARAIKDAHAVCDALDEGHSAKAVIKAVAKATGLSAKGAKTFAVDAASAYC FT PQYVTSS" FT tRNA complement(129642..129714) FT /gene="argV" FT /locus_tag="argV" FT /note="argV, len: 73 nt. Equivalent to argV, len: 73 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 73 nt overlap). tRNA-Arg, anticodon ccg." FT CDS 129828..131480 FT /transl_table=11 FT /gene="argS" FT /locus_tag="Mb1324" FT /product="PROBABLE ARGINYL-TRNA SYNTHETASE ARGS (ARGRS) FT (Arginine--tRNA ligase)" FT /EC_number="6.1.1.19" FT /note="Mb1324, argS, len: 550 aa. Equivalent to Rv1292, FT len: 550 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 550 aa overlap). Probable argS, FT Arginyl-tRNA synthetase (EC 6.1.1.19), highly similar to FT SYR_MYCLE|P45840 Mycobacterium leprae (550 aa), FASTA FT scores: opt: 3115, E(): 0, (84.9% identity in 550 aa FT overlap). Contains PS00178 Aminoacyl-transfer RNA FT synthetases class-I signature. BELONGS TO CLASS-I FT AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:P67570" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:P67570" FT /protein_id="CAD94185.1" FT /translation="MTPADLAELLKATAAAVLAERGLDASALPQMVTVERPRIPEHGDY FT ASNLAMQLAKKVGTNPRELAGWLAEALTKVDGIASAEVAGPGFINMRLETAAQAKVVTS FT VIDAGHSYGHSLLLAGRKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLTTQGADVVR FT EYYFNDHGAQIDRFANSLIAAAKGEPTPQDGYAGSYITNIAEQVLQKAPDALSLPDAEL FT RETFRAIGVDLMFDHIKQSLHEFGTDFDVYTHEDSMHTGGRVENAIARLRETGNIYEKD FT GATWLRTSAFGDDKDRVVIKSDGKPAYIAGDLAYYLDKRQRGFDLCIYMLGADHHGYIA FT RLKAAAAAFGDDPATVEVLIGQMVNLVRDGQPVRMSKRAGTVLTLDDLVEAIGVDAARY FT SLIRSSVDTAIDIDLALWSSASNENPVYYVQYAHARLSALARNAAELALIPDTNHLELL FT NHDKEGTLLRTLGEFPRVLETAASLREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEQP FT TDLHTARLALCQATRQVIANGLAIIGVTAPERM" FT CDS 131477..132820 FT /transl_table=11 FT /gene="lysA" FT /locus_tag="Mb1325" FT /product="PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP FT DECARBOXYLASE)" FT /EC_number="4.1.1.20" FT /note="Mb1325, lysA, len: 447 aa. Equivalent to Rv1293, FT len: 447 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 447 aa overlap). Probable lysA, FT diaminopimelate decarboxylase (EC 4.1.1.20) (see citation FT below), almost identical to DCDA_MYCTU|P31848. Contains FT PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P FT attachment site, PS00879 Orn/DAP/Arg decarboxylases family FT 2 signature 2. BELONGS TO FAMILY 2 OF ORNITHINE, DAP, AND FT ARGININE DECARBOXYLASES." FT /db_xref="GOA:P0A5M5" FT /db_xref="InterPro:IPR000183" FT /db_xref="UniProtKB/Swiss-Prot:P0A5M5" FT /protein_id="CAD94186.1" FT /translation="MNELLHLAPNVWPRNTTRDEVGVVCIAGIPLTQLAQEYGTPLFVI FT DEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGELAVALHA FT SFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLT FT VGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVD FT GFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAELAAKLGT FT IVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMS FT DNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHCESGDIIVRDTWVPDDIRPGDLVAV FT AATGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRETVDDLLSLEVR" FT CDS 132824..134149 FT /transl_table=11 FT /gene="thrA" FT /locus_tag="Mb1326" FT /product="PROBABLE HOMOSERINE DEHYDROGENASE THRA" FT /EC_number="1.1.1.3" FT /note="Mb1326, thrA, len: 441 aa. Equivalent to Rv1294, FT len: 441 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 441 aa overlap). Probable thrA (hom), FT homoserine dehydrogenase (EC 1.1.1.3), highly similar to FT DHOM_MYCLE|P46806 from Mycobacterium leprae (441 aa), FASTA FT scores: opt: 2437, E():0, (89.5% identity in 438 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A; FT PS01042 Homoserine dehydrogenase signature. BELONGS TO THE FT HOMOSERINE DEHYDROGENASE FAMILY." FT /db_xref="GOA:P63630" FT /db_xref="InterPro:IPR019811" FT /db_xref="UniProtKB/Swiss-Prot:P63630" FT /protein_id="CAD94187.1" FT /translation="MPGDEKPVGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRG FT IGVRRVTTDRGVPIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVT FT ANKALLATSTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGT FT TNYILSAMDSTGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTA FT DDVYREGITKVTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPL FT AAVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPRESKY FT AQLPVAPMGFIETRYYVSMNVADKPGVLSAVAAEFAKREVSIAEVRQEGVVDEGGRRVG FT ARIVVVTHLATDAALSETVDALDDLDVVQGVSSVIRLEGTGL" FT CDS 134146..135228 FT /transl_table=11 FT /gene="thrC" FT /locus_tag="Mb1327" FT /product="PROBABLE THREONINE SYNTHASE THRC" FT /EC_number="4.2.3.1" FT /note="Mb1327, thrC, len: 360 aa. Equivalent to Rv1295, FT len: 360 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 360 aa overlap). Probable thrC, threonine FT synthase (EC 4.2.3.1) (see first citation below), highly FT similar to THRC_MYCLE|P45837 Mycobacterium leprae (360 aa), FT FASTA scores: opt: 2202, E(): 0, (93.9% identity in 359 aa FT overlap). Contains PS00165 Serine/threonine dehydratases FT pyridoxal-phosphate attachment site." FT /db_xref="GOA:P66903" FT /db_xref="HSSP:1E5X" FT /db_xref="InterPro:IPR004450" FT /db_xref="UniProtKB/Swiss-Prot:P66903" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94188.1" FT /translation="MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAAT FT NLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYA FT ARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVN FT SVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPR FT MLGTQAAGAAPLVLGEPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEIL FT AAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDM FT PSVSPVPVDPVAVVEKLGLA" FT CDS 135446..136396 FT /transl_table=11 FT /gene="thrB" FT /locus_tag="Mb1328" FT /product="PROBABLE HOMOSERINE KINASE THRB" FT /EC_number="2.7.1.39" FT /note="Mb1328, thrB, len: 316 aa. Equivalent to Rv1296, FT len: 316 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 316 aa overlap). Probable thrB, FT homoserine kinase (EC 2.7.1.39) (see citation below), FT highly similar to KHSE_MYCLE|P45836 from Mycobacterium FT leprae (314 aa), FASTA scores, opt: 1657, E(): 0, (82.0% FT identity in 311 aa overlap). Contains PS00639 Eukaryotic FT thiol (cysteine) proteases histidine active site, and FT PS00627 GHMP kinases putative ATP-binding domain." FT /db_xref="GOA:P65225" FT /db_xref="InterPro:IPR014721" FT /db_xref="UniProtKB/Swiss-Prot:P65225" FT /protein_id="CAD94189.1" FT /translation="MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYDEIIVET FT TDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHGLQAAGVSAAGLAVRCRNAIPHSRGLGS FT SAAAVVGGLAAVNGLVVQTDSSPSSDAELIQLASEFEGHPDNAAAAVLGGAVVSWTDHS FT GDRPNYSAVSLRLHPDIRLFTAIPEQRSSTAETRVLLPAQVSHDDARFNVSRAALLVVA FT LTERPDLLMAATEDLLHQPQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIALSTDSE FT LPTDAVEFGAAKGFAVTELTVGEAVRWSPTVRVPG" FT CDS 136653..138461 FT /transl_table=11 FT /gene="rho" FT /locus_tag="Mb1329" FT /product="PROBABLE TRANSCRIPTION TERMINATION FACTOR RHO FT HOMOLOG" FT /note="Mb1329, rho, len: 602 aa. Equivalent to Rv1297, len: FT 602 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 602 aa overlap). Probable rho, transcription FT termination factor homolog, highly similar to many e.g. FT RHO_MYCLE|P45835 Mycobacterium leprae (610 aa), FASTA FT scores: (81.5% identity in 612 aa overlap). CONTAINS 1 RNA FT RECOGNITION MOTIF (RRM)." FT /db_xref="GOA:P66029" FT /db_xref="HSSP:1PV4" FT /db_xref="InterPro:IPR004665" FT /db_xref="UniProtKB/Swiss-Prot:P66029" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94190.1" FT /translation="MTDTDLITAGESTDGKPSDAAATDPPDLNADEPAGSLATMVLPEL FT RALANRAGVKGTSGMRKNELIAAIEEIRRQANGAPAVDRSAQEHDKGDRPPSSEAPATQ FT GEQTPTEQIDSQSQQVRPERRSATREAGPSGSGERAGTAADDTDNRQGGQQDAKTEERG FT TDAGGDQGGDQQASGGQQARGDEDGEARQGRRGRRFRDRRRRGERSGDGAEAELREDDV FT VQPVAGILDVLDNYAFVRTSGYLPGPHDVYVSMNMVRKNGMRRGDAVTGAVRVPKEGEQ FT PNQRQKFNPLVRLDSINGGSVEDAKKRPEFGKLTPLYPNQRLRLETSTERLTTRVIDLI FT MPIGKGQRALIVSPPKAGKTTILQDIANAITRNNPECHLMVVLVDERPEEVTDMQRSVK FT GEVIASTFDRPPSDHTSVAELAIERAKRLVEQGKDVVVLLDSITRLGRAYNNASPASGR FT ILSGGVDSTALYPPKRFLGAARNIEEGGSLTIIATAMVETGSTGDTVIFEEFKGTGNAE FT LKLDRKIAERRVFPAVDVNPSGTRKDELLLSPDEFAIVHKLRRVLSGLDSHQAIDLLMS FT QLRKTKNNYEFLVQVSKTTPGSMDSD" FT CDS 138612..138854 FT /transl_table=11 FT /gene="rpmE" FT /locus_tag="Mb1330" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L31 RPME" FT /note="Mb1330, rpmE, len: 80 aa. Equivalent to Rv1298, len: FT 80 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 80 aa overlap). Probable rpmE, 50s ribosomal FT protein L31, highly similar to many e.g. RL31_MYCLE|P45834 FT 50s ribosomal protein L31 from Mycobacterium leprae (84 FT aa), FASTA scores: opt: 490, E(): 5.5e-28, (89.6% identity FT in 77 aa overlap). Contains PS01143 Ribosomal protein L31 FT signature. BELONGS TO THE L31P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P66188" FT /db_xref="InterPro:IPR002150" FT /db_xref="UniProtKB/Swiss-Prot:P66188" FT /protein_id="CAD94191.1" FT /translation="MKSDIHPAYEETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPFY FT TGKQKILDSGGRVARFEKRYGKRKVGADKAVSTGK" FT CDS 138944..140017 FT /transl_table=11 FT /gene="prfA" FT /locus_tag="Mb1331" FT /product="PROBABLE PEPTIDE CHAIN RELEASE FACTOR 1 PRFA FT (RF-1)" FT /note="Mb1331, prfA, len: 357 aa. Equivalent to Rv1299, FT len: 357 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 357 aa overlap). Probable prfA, peptide FT chain release factor 1 (rf-1), highly similar to many e.g. FT RF1_MYCLE|P45833 peptide chain release factor 1 (rf-1) from FT Mycobacterium leprae (357 aa), FASTA scores: opt: 2047, FT E(): 0, (89.3% identity in 356 aa overlap); also similar to FT Mycobacterium tuberculosis Rv3105c, prfB peptide chain FT release factor 2. Contains PS00745 Prokaryotic-type class I FT peptide chain release factors signature. BELONGS TO THE FT PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY." FT /db_xref="GOA:P66017" FT /db_xref="HSSP:1GQE" FT /db_xref="InterPro:IPR004373" FT /db_xref="UniProtKB/Swiss-Prot:P66017" FT /protein_id="CAD94192.1" FT /translation="MTQPVQTIDVLLAEHAELELALADPALHSNPAEARRVGRRFARLA FT PIVATHRKLTSARDDLETARELVASDESFAAEVAALEARVGELDAQLTDMLAPRDPHDA FT DDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWAVTVLDETTSDLGGYKDATLAIA FT SKADTPDGVWSRMKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVGQVQIDESD FT LRIDVFRSSGKGGQGVNTTDSAVRITHLPTGIVVTCQNERSQLQNKTRALQVLAARLQA FT MAEEQALADASADRASQIRTVDRSERIRTYNFPENRITDHRIGYKSHNLDQVLDGDLDA FT LFDALSAADKQSRLRQS" FT CDS 140014..140991 FT /transl_table=11 FT /gene="hemK" FT /locus_tag="Mb1332" FT /product="PROBABLE HEMK PROTEIN HOMOLOG HEMK" FT /EC_number="2.1.1.-" FT /note="Mb1332, hemK, len: 325 aa. Equivalent to Rv1300, FT len: 325 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 325 aa overlap). Probable hemK protein FT homolog (EC 2.1.1.-), homology suggests translation may FT start at aa 22, highly similar to many e.g. FT HEMK_MYCLE|P45832 Mycobacterium leprae (288 aa), FASTA FT scores: opt: 936, E(): 0, (76.7% identity in 189 aa FT overlap). BELONGS TO THE HEMK FAMILY OF MODIFICATION FT METHYLASES." FT /db_xref="GOA:Q7U086" FT /db_xref="InterPro:IPR007848" FT /db_xref="UniProtKB/TrEMBL:Q7U086" FT /protein_id="CAD94193.1" FT /translation="MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARC FT DAEQLAAHLAGTDRGRLPLFEPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLH FT VGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALAQHRANLGLKARIIG FT IDDSDCALDYARRNAAGTPVELVRADVTTPCLLPELDGQVDLMVSNPPYIPDAAVLEPE FT VAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLF FT VDVQARKDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR" FT CDS 141007..141660 FT /transl_table=11 FT /gene="Mb1333" FT /locus_tag="Mb1333" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1333, -, len: 217 aa. Equivalent to Rv1301, len: FT 217 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 217 aa overlap). Conserved hypothetical FT protein, highly similar to YRFE_MYCLE|P45831 hypothetical FT 22.7 kd protein in rfe-hemk intergenic region, (220 aa), FT FASTA scores: opt: 1168, E(): 0, (82.8% identity in 215 aa FT overlap). Contains PS01147 Hypothetical SUA5/yciO/yrdC FT family signature. BELONGS TO THE SUA5/YRDC/YCIO/YWLC FT FAMILY." FT /db_xref="HSSP:1JCU" FT /db_xref="InterPro:IPR006070" FT /db_xref="UniProtKB/TrEMBL:Q7U085" FT /protein_id="CAD94194.1" FT /translation="MTETFDCADPEQRSRGIVSAVGAIKAGQLVVMPTDTVYGIGADAF FT DSSAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYSMPDGARELIRAFWPGALSLVVVQ FT APSLQWDLGDAHGTVMLRMPLHPVAIELLREVGPMAVSSANISGHPPPVDAEQARSQLG FT DHVAVYLDAGPSEQQAGSTIVDLTGATPRVLRQGPVSTERIAEVLGVDAASLFG" FT CDS 141744..142958 FT /transl_table=11 FT /gene="rfe" FT /locus_tag="Mb1334" FT /product="PUTATIVE UNDECAPAPRENYL-PHOSPHATE FT ALPHA-N-ACETYLGLUCOSAMINYLTRANSFERASE RFE" FT /EC_number="2.4.1.-" FT /note="Mb1334, rfe, len: 404 aa. Equivalent to Rv1302, len: FT 404 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 404 aa overlap). Putative rfe, FT undecaprenyl-phosphate FT alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-), FT equivalent to RFE_MYCLE|P45830 Mycobacterium leprae (398 FT aa), FASTA scores, opt: 2285, E(): 0, (89.2% identity in FT 398 aa overlap)." FT /db_xref="GOA:Q7U084" FT /db_xref="InterPro:IPR000715" FT /db_xref="UniProtKB/TrEMBL:Q7U084" FT /protein_id="CAD94195.1" FT /translation="MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITY FT FATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGLAMFLGIVGAVFLASQLPALTRGFV FT YSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPVGG FT VGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHG FT GDVLYYPPAVISVVLAGACLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQ FT NAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRAGRSAFSPDKMHLHHRLLQIG FT HSHRRVVLIIYLWVGIGAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYY FT DPDLD" FT CDS 143215..143700 FT /transl_table=11 FT /gene="Mb1335" FT /locus_tag="Mb1335" FT /product="CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN" FT /note="Mb1335, -, len: 161 aa. Equivalent to Rv1303, len: FT 161 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 161 aa overlap). Conserved hypothetical FT transmembrane protein, highly similar to P53431|Y02N_MYCLE FT hypothetical Mycobacterium leprae protein (153 aa), FASTA FT score: opt: 636, E():0, (69.8% identity in 149 aa FT overlap)." FT /db_xref="GOA:P64802" FT /db_xref="InterPro:IPR008413" FT /db_xref="UniProtKB/Swiss-Prot:P64802" FT /protein_id="CAD94196.1" FT /translation="MTTPAQDAPLVFPSVAFRPVRLFFINVGLAAVAMLVAGVFGHLTV FT GMFLGLGLLLGLLNALLVRRSAESITAKEHPLKRSMALNSASRLAIITILGLIIAYIFR FT PAGLGVVFGLAFFQVLLVATTALPVLKKLRTATEEPVATYSSNGQTGGSEGRSASDD" FT CDS 143693..144445 FT /transl_table=11 FT /gene="atpB" FT /locus_tag="Mb1336" FT /product="PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6)" FT /EC_number="3.6.3.14" FT /note="Mb1336, atpB, len: 250 aa. Equivalent to Rv1304, FT len: 250 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 250 aa overlap). Probable atpB, ATP FT synthase A chain (EC 3.6.3.14), highly similar to FT ATP6_MYCLE|P45829 Mycobacterium leprae (251 aa), FASTA FT scores: opt: 1382, E(): 0, (84.0% identity in 250 aa FT overlap). Contains PS00449 ATP synthase A subunit FT signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) FT - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON FT CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), FT GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN FT SUBUNITS: A, B AND C. BELONGS TO THE ATPASE A CHAIN FT FAMILY." FT /db_xref="GOA:P63655" FT /db_xref="HSSP:1C17" FT /db_xref="InterPro:IPR000568" FT /db_xref="UniProtKB/Swiss-Prot:P63655" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94197.1" FT /translation="MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAF FT YLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISNWL FT AVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLLKG FT HVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLF FT VGAIQAFIFALLTILYFSQAMELEEEHH" FT CDS 144494..144739 FT /transl_table=11 FT /gene="atpE" FT /locus_tag="Mb1337" FT /product="PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING FT PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN)" FT /EC_number="3.6.3.14" FT /note="Mb1337, atpE, len: 81 aa. Equivalent to Rv1305, len: FT 81 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 81 aa overlap). Probable atpE, ATP synthase C FT chain (EC 3.6.3.14), highly similar to P45828|ATPL_MYCLE FT Mycobacterium leprae (92.6% identity in 81 aa overlap). FT Contains PS00605 ATP synthase C subunit signature. SUBUNIT: FT F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC FT CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FT FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), FT EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. FT BELONGS TO THE ATPASE C CHAIN FAMILY." FT /db_xref="GOA:P63692" FT /db_xref="InterPro:IPR002379" FT /db_xref="UniProtKB/Swiss-Prot:P63692" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94198.1" FT /translation="MDPTIAAGALIGGGLIMAGGAIGAGIGDGVAGNALISGVARQPEA FT QGRLFTPFFITVGLVEAAYFINLAFMALFVFATPVK" FT CDS 144770..145285 FT /transl_table=11 FT /gene="atpF" FT /locus_tag="Mb1338" FT /product="PROBABLE ATP SYNTHASE B CHAIN ATPF" FT /EC_number="3.6.3.14" FT /note="Mb1338, atpF, len: 171 aa. Equivalent to Rv1306, FT len: 171 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 171 aa overlap). Probable atpF, ATP FT synthase B chain (EC 3.6.3.14), highly similar to FT ATPF_MYCLE P45827 (170 aa), FASTA scores, opt: 802, E(): 0, FT (79.5% identity in 171 aa overlap). SUBUNIT: F-TYPE ATPASES FT HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - FT THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: FT ALPHA(3), BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) FT HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE FT B CHAIN FAMILY." FT /db_xref="GOA:P63657" FT /db_xref="InterPro:IPR002146" FT /db_xref="UniProtKB/Swiss-Prot:P63657" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94199.1" FT /translation="MGEVSAIVLAASQAAEEGGESSNFLIPNGTFFVVLAIFLVVLAVI FT GTFVVPPILKVLRERDAMVAKTLADNKKSDEQFAAAQADYDEAMTEARVQASSLRDNAR FT ADGRKVIEDARVRAEQQVASTLQTAHEQLKRERDAVELDLRAHVGTMSATLASRILGVD FT LTASAATR" FT CDS 145292..146632 FT /transl_table=11 FT /gene="atpH" FT /locus_tag="Mb1339" FT /product="PROBABLE ATP SYNTHASE DELTA CHAIN ATPH" FT /EC_number="3.6.3.14" FT /note="Mb1339, atpH, len: 446 aa. Equivalent to Rv1307, FT len: 446 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 446 aa overlap). Probable atpH, ATP FT synthase delta chain (EC 3.6.3.14). This protein is much FT longer than that of other bacterial delta chains, the FT C-terminal region is homologous to delta chains while the FT N-terminal region is similar to B/B' subunits e.g. FT ATPD_STRLI|P50008 ATP synthase delta chain from FT Streptomyces lividans (273 aa), FASTA scores: opt: 505, FT E(): 5.4e-23, (35.0% identity in 277 aa overlap); and FT ATPF_HAEIN|P43720 ATP synthase B chain (EC 3.6.1.34) from FT Haemophilus influenzae (156 aa), FASTA scores: opt: 216, FT E(): 1.2e-06, (26.1% identity in 153 aa overlap). SUBUNIT: FT F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC FT CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FT FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), FT EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. FT BELONGS TO THE ATPASE DELTA CHAIN FAMILY." FT /db_xref="GOA:P0A501" FT /db_xref="InterPro:IPR000711" FT /db_xref="UniProtKB/Swiss-Prot:P0A501" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94200.1" FT /translation="MSTFIGQLFGFAVIVYLVWRFIVPLVGRLMSARQDTVRQQLADAA FT AAADRLAEASQAHTKALEDAKSEAHRVVEEARTDAERIAEQLEAQADVEAERIKMQGAR FT QVDLIRAQLTRQLRLELGHESVRQARELVRNHVADQAQQSATVDRFLDQLDAMAPATAD FT VDYPLLAKMRSASRRALTSLVDWFGTMAQDLDHQGLTTLAGELVSVARLLDREAVVTRY FT LTVPAEDATPRIRLIERLVSGKVGAPTLEVLRTAVSKRWSANSDLIDAIEHVSRQALLE FT LAERAGQVDEVEDQLFRFSRILDVQPRLAILLGDCAVPAEGRVRLLRKVLERADSTVNP FT VVVALLSHTVELLRGQAVEEAVLFLAEVAVARRGEIVAQVGAAAELSDAQRTRLTEVLS FT RIYGHPVTVQLHIDAALLGGLSIAVGDEVIDGTLSSRLAAAEARLPD" FT CDS 146677..148326 FT /transl_table=11 FT /gene="atpA" FT /locus_tag="Mb1340" FT /product="PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA" FT /EC_number="3.6.3.14" FT /note="Mb1340, atpA, len: 549 aa. Equivalent to Rv1308, FT len: 549 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 549 aa overlap). Probable atpA, ATP FT synthase alpha chain (EC 3.6.3.14), highly similar to FT ATPA_MYCLE|P45825 from Mycobacterium leprae (558 aa), FASTA FT scores: opt: 3233, E(): 0, (90.3% identity in 547 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A, FT PS00152 ATP synthase alpha and beta subunits signature. FT SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE FT CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. FT CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), FT DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B FT AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY." FT /db_xref="GOA:P63674" FT /db_xref="InterPro:IPR000194" FT /db_xref="UniProtKB/Swiss-Prot:P63674" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94201.1" FT /translation="MAELTIPADDIQSAIEEYVSSFTADTSREEVGTVVDAGDGIAHVE FT GLPSVMTQELLEFPGGILGVALNLDEHSVGAVILGDFENIEEGQQVKRTGEVLSVPVGD FT GFLGRVVNPLGQPIDGRGDVDSDTRRALELQAPSVVHRQGVKEPLQTGIKAIDAMTPIG FT RGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDPKKQVRCVYVAIGQKGTTIAAVRRT FT LEEGGAMDYTTIVAAAASESAGFKWLAPYTGSAIAQHWMYEGKHVLIIFDDLTKQAEAY FT RAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDDLGGGSLTGLPIIETKANDISAY FT IPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQ FT YRELEAFAAFASDLDAASKAQLERGARLVELLKQPQSQPMPVEEQVVSIFLGTGGHLDS FT VPVEDVRRFETELLDHMRASEEEILTEIRDSQKLTEEAADKLTEVIKNFKKGFAATGGG FT SVVPDEHVEALDEDKLAKEAVKVKKPAPKKKK" FT CDS 148333..149250 FT /transl_table=11 FT /gene="atpG" FT /locus_tag="Mb1341" FT /product="PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG" FT /EC_number="3.6.3.14" FT /note="Mb1341, atpG, len: 305 aa. Equivalent to Rv1309, FT len: 305 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 305 aa overlap). Probable atpG, ATP FT synthase gamma chain (EC 3.6.3.14), highly similar to FT ATPG_MYCLE|P45824 ATP synthase gamma chain from FT Mycobacterium leprae (298 aa), FASTA scores: opt: 1579, FT E():0, (83.9% identity in 305 aa overlap). Contains PS00153 FT ATP synthase gamma subunit signature. SUBUNIT: F-TYPE FT ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND FT CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE FT SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), FT EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. FT BELONGS TO THE ATPASE GAMMA CHAIN FAMILY." FT /db_xref="GOA:P63672" FT /db_xref="HSSP:1FS0" FT /db_xref="InterPro:IPR000131" FT /db_xref="UniProtKB/Swiss-Prot:P63672" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94202.1" FT /translation="MAATLRELRGRIRSAGSIKKITKAQELIATSRIARAQARLESARP FT YAFEITRMLTTLAAEAALDHPLLVERPEPKRAGVLVVSSDRGLCGAYNANIFRRSEELF FT SLLREAGKQPVLYVVGRKAQNYYSFRNWNITESWMGFSEQPTYENAAEIASTLVDAFLL FT GTDNGEDQRSDSGEGVDELHIVYTEFKSMLSQSAEAHRIAPMVVEYVEEDIGPRTLYSF FT EPDATMLFESLLPRYLTTRVYAALLESAASELASRQRAMKSATDNADDLIKALTLMANR FT ERQAQITQEISEIVGGANALAEAR" FT CDS 149290..150750 FT /transl_table=11 FT /gene="atpD" FT /locus_tag="Mb1342" FT /product="PROBABLE ATP SYNTHASE BETA CHAIN ATPD" FT /EC_number="3.6.3.14" FT /note="Mb1342, atpD, len: 486 aa. Equivalent to Rv1310, FT len: 486 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 486 aa overlap). Probable atpD, ATP FT synthase beta chain (EC 3.6.3.14), highly similar to FT ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa), FASTA FT score: opt: 2916, E(): 0, (92.6% identity in 484 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A, FT PS00152 ATP synthase alpha and beta subunits signature. FT SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE FT CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. FT CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), FT DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B FT AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY." FT /db_xref="GOA:P63678" FT /db_xref="HSSP:1SKY" FT /db_xref="InterPro:IPR000194" FT /db_xref="UniProtKB/Swiss-Prot:P63678" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94203.1" FT /translation="MTTTAEKTDRPGKPGSSDTSGRVVRVTGPVVDVEFPRGSIPELFN FT ALHAEITFESLAKTLTLEVAQHLGDNLVRTISLQPTDGLVRGVEVIDTGRSISVPVGEG FT VKGHVFNALGDCLDEPGYGEKFEHWSIHRKPPAFEELEPRTEMLETGLKVVDLLTPYVR FT GGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELAEANVLK FT DTALVFGQMDEPPGTRMRVALSALTMAEWFRDEQGQDVLLFIDNIFRFTQAGSEVSTLL FT GRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDA FT TTELSRAVFSKGIFPAVDPLASSSTILDPSVVGDEHYRVAQEVIRILQRYKDLQDIIAI FT LGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIEAFDRLCKGDF FT DHVPEQAFFLIGGLDDLAKKAESLGAKL" FT CDS 150764..151129 FT /transl_table=11 FT /gene="atpC" FT /locus_tag="Mb1343" FT /product="PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC" FT /EC_number="3.6.3.14" FT /note="Mb1343, atpC, len: 121 aa. Equivalent to Rv1311, FT len: 121 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 121 aa overlap). Probable atpC, ATP FT synthase epsilon chain (EC 3.6.3.14), highly similar to FT ATPE_MYCLE|P45822 Mycobacterium leprae (124 aa), FASTA FT scores: opt: 682, E(): 5.4e-40, (87.6% identity in 121 aa FT overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) FT - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON FT CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), FT GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN FT SUBUNITS: A, B AND C. BELONGS TO THE ATPASE EPSILON CHAIN FT FAMILY." FT /db_xref="GOA:P63663" FT /db_xref="InterPro:IPR001469" FT /db_xref="UniProtKB/Swiss-Prot:P63663" FT /protein_id="CAD94204.1" FT /translation="MAELNVEIVAVDRNIWSGTAKFLFTRTTVGEIGILPRHIPLVAQL FT VDDAMVRVEREGEKDLRIAVDGGFLSVTEEGVSILAESAEFESEIDEAAAKQDSESDDP FT RIAARGRARLRAVGAID" FT CDS 151137..151571 FT /transl_table=11 FT /gene="Mb1344" FT /locus_tag="Mb1344" FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN" FT /note="Mb1344, -, len: 144 aa. Equivalent to Rv1312, len: FT 147 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 142 aa overlap). Conserved hypothetical FT secreted protein with potential N-terminal signal sequence. FT Highly similar to P53432|Y02W_MYCLE hypothetical FT Mycobacterium leprae protein (147 aa), FASTA score: opt: FT 884, E(): 0, (88.4% identity in 147 aa overlap). N-terminus FT hydrophobic. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a 2 bp deletion (cg-*) at the 3' end FT leads to a slightly shorter product compared to FT Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 FT aa)." FT /db_xref="InterPro:IPR019675" FT /db_xref="UniProtKB/TrEMBL:Q7U083" FT /protein_id="CAD94205.1" FT /translation="MSVPMIGMVVLVVVLGLAVLALSYRLWKLRQGGTAGIMRDIPAVG FT GHGWRHGVIRYRGGEAAFYRLSSLRLWPDRRLSRRGVEIISRRAPRGDEFDIMTDEIVV FT VELCDSTQDRRVGYEIALDRGALTAFLSWLESRPSPRAPP" FT repeat_region 151589..151608 FT /rpt_type=INVERTED FT /note="20 bp imperfect inverted repeat, IRR, FT AGCAGACGCAAAAGCCCCCA, flanking IS element IS1557." FT repeat_region complement(151589..153088) FT /mobile_element="insertion sequence:IS1557" FT /locus_tag="IS1557-2" FT /note="IS1557-2, len: 1498 nt. Equivalent to IS1557, len: FT 1509 nt, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 785 nt overlap). IS1557-2nd copy." FT CDS complement(151618..152349) FT /transl_table=11 FT /gene="Mb1345c" FT /locus_tag="Mb1345c" FT /product="POSSIBLE TRANSPOSASE [SECOND PART]" FT /note="Mb1345c, -, len: 243 aa. Equivalent to 3' end of FT Rv1313c, len: 444 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 243 aa overlap). Possible FT IS1557 transposase, similar to several transposases e.g. FT U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium FT DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% FT identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase FT for insertion sequence element IS1001 from Bordetella FT parapertussis (406 aa), FASTA scores: opt: 254, E(): FT 3.3e-10, (24.9% identity in 402 aa overlap). Also similar FT to putative Mycobacterium tuberculosis transposases, Rv3798 FT and Rv0741. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1313c exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a 12 bp to 1 bp FT substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts, FT Mb1345c and Mb1346c." FT /db_xref="GOA:Q7TTF3" FT /db_xref="InterPro:IPR002560" FT /db_xref="UniProtKB/TrEMBL:Q7TTF3" FT /protein_id="CAD94206.1" FT /translation="MFFDALGAERAAQITHVSADAADWIADVVTERCPDAIQCADPFHV FT VAWATEALDVERRRAWNDARAIARTEPKWGRGRPGKNAAPRPGRERARRLKGARYALWK FT NPEDLTERQSAKLAWIAKTDPRLYRAYLLKESLRHVFSVKGEEGKQALDRWISWAQRCR FT IPVFVELAARIKRHRVAIDAALDHGLSQGLIESTNTKIRLLTRIAFGFRSPQALIALAM FT LTLAGHRPTLPGRHNHPQISQ" FT CDS complement(152324..152941) FT /transl_table=11 FT /gene="Mb1346c" FT /locus_tag="Mb1346c" FT /product="POSSIBLE TRANSPOSASE [FIRST PART]" FT /note="Mb1346c, -, len: 205 aa. Equivalent to 5' end of FT Rv1313c, len: 444 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.5% identity in 195 aa overlap). Possible FT IS1557 transposase, similar to several transposases e.g. FT U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium FT DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% FT identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase FT for insertion sequence element IS1001 from Bordetella FT parapertussis (406 aa), FASTA scores: opt: 254, E(): FT 3.3e-10, (24.9% identity in 402 aa overlap). Also similar FT to putative Mycobacterium tuberculosis transposases, Rv3798 FT and Rv0741. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1313c exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a 12 bp to 1 bp FT substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts, FT Mb1345c and Mb1346c." FT /db_xref="GOA:Q7TTK1" FT /db_xref="InterPro:IPR002560" FT /db_xref="UniProtKB/TrEMBL:Q7TTK1" FT /protein_id="CAD94207.1" FT /translation="MRNVRLFRALLGVDKRTVIEDIEFEEDDAGDGARVIARVRPRSAV FT LRRCGRCGRKASWYDRGAGLRQWRSLDWGTVEVFLEAEAPRVNCPTHGPTVVAVPWARH FT HAGHTYAFDDTVAWLAVACSKTAVCELMRIAWRTVGAIVARVWADTEKRIDRFANLRRI FT GIDEISYKRHHRYLTVVVDHDSGRLVWAAPSHPGLVLRCPGR" FT repeat_region complement(153069..153088) FT /rpt_type=INVERTED FT /note="20 bp imperfect inverted repeat, IRL, FT AGCAGACGCGAAAGCCCCCA, flanking IS element IS1557." FT CDS complement(153107..153688) FT /transl_table=11 FT /gene="Mb1347c" FT /locus_tag="Mb1347c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1347c, -, len: 193 aa. Equivalent to Rv1314c, len: FT 193 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 193 aa overlap). Conserved hypothetical FT protein, highly similar to P53523|Y02Y_MYCLE hypothetical FT Mycobacterium leprae protein (191 aa), FASTA score: FT opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some FT similarity with YDHW_CITFR|P45515 hypothetical 19.8 kd FT protein in dhar-dhat intergenic region (176 aa), FASTA FT scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa FT overlap). Also similar to hypothetical protein FT AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA FT score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa FT overlap)." FT /db_xref="GOA:P64804" FT /db_xref="InterPro:IPR002779" FT /db_xref="UniProtKB/Swiss-Prot:P64804" FT /protein_id="CAD94208.1" FT /translation="MAVHLTRIYTRTGDDGTTGLSDMSRVAKTDARLVAYADCDEANAA FT IGAALALGHPDTQITDVLRQIQNDLFDAGADLSTPIVENPKHPPLRIAQSYIDRLEGWC FT DAYNAGLPALKSFVLPGGSPLSALLHVARTVVRRAERSAWAAVDAHPEGVSVLPAKYLN FT RLSDLLFILSRVANPDGDVLWRPGGDRTAS" FT CDS 153757..155013 FT /transl_table=11 FT /gene="murA" FT /locus_tag="Mb1348" FT /product="PROBABLE UDP-N-ACETYLGLUCOSAMINE FT 1-CARBOXYVINYLTRANSFERASE MURA" FT /EC_number="2.5.1.7" FT /note="Mb1348, murA, len: 418 aa. Equivalent to Rv1315, FT len: 418 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 418 aa overlap). Probable murA, FT UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC FT 2.5.1.7), highly similar to many e.g. MURA_MYCLE|P45821 FT (418 aa), FASTA scores: opt: 2495, E(): 0, (96.2% identity FT in 396 aa overlap). BELONGS TO THE EPSP SYNTHASE FAMILY. FT MURA SUBFAMILY." FT /db_xref="GOA:P0A5L3" FT /db_xref="HSSP:1UAE" FT /db_xref="InterPro:IPR005750" FT /db_xref="UniProtKB/Swiss-Prot:P0A5L3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94209.1" FT /translation="MAERFVVTGGNRLSGEVAVGGAKNSVLKLMAATLLAEGTSTITNC FT PDILDVPLMAEVLRGLGATVELDGDVARITAPDEPKYDADFAAVRQFRASVCVLGPLVG FT RCKRARVALPGGDAIGSRPLDMHQAGLRQLGAHCNIEHGCVVARAETLRGAEIQLEFPS FT VGATENILMAAVVAEGVTTIHNAAREPDVVDLCTMLNQMGAQVEGAGSPTMTITGVPRL FT HPTEHRVIGDRIVAATWGIAAAMTRGDISVAGVDPAHLQLVLHKLHDAGATVTQTDASF FT RVTQYERPKAVNVATLPFPGFPTDLQPMAIALASIADGTSMITENVFEARFRFVEEMIR FT LGADARTDGHHAVVRGLPQLSSAPVWCSDIRAGAGLVLAGLVADGDTEVHDVFHIDRGY FT PLFVENLVSLGAEIERVCC" FT rRNA 155282..156818 FT /gene="rrs" FT /locus_tag="rrs" FT /product="ribosomal RNA 16S" FT /note="rrs, len: 1537 nt. Equivalent to rrs, len: 1537 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 1537 nt overlap). 16s rRNA gene." FT rRNA 157094..160231 FT /gene="rrl" FT /locus_tag="rrl" FT /product="ribosomal RNA 23S" FT /note="rrl, len: 3138 nt. Equivalent to rrl, len: 3138 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 3138 nt overlap). 23S rRNA gene (approximate FT coordinates)." FT rRNA 160335..160449 FT /gene="rrf" FT /locus_tag="rrf" FT /product="ribosomal RNA 5S" FT /note="rrf, len: 115 nt. Equivalent to rrf, len: 115 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 115 nt overlap). 5S rRNA gene. Identical to FT Em_ba:MT5SRR, D10035 M.tuberculosis 5S rRNA, len: 116 nt." FT CDS complement(160569..161066) FT /transl_table=11 FT /gene="ogt" FT /locus_tag="Mb1349c" FT /product="PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE FT METHYLTRANSFERASE OGT (6-O-methylguanine-DNA FT methyltransferase) FT (O-6-methylguanine-DNA-alkyltransferase)" FT /EC_number="2.1.1.63" FT /note="Mb1349c, ogt, len: 165 aa. Equivalent to Rv1316c, FT len: 165 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 165 aa overlap). Probable ogt, FT methylated-dna--protein-cysteine methytransferase (EC FT 2.1.1.63), similar to many e.g. OGT_HAEIN|P44687 FT Haemophilus influenzae (190 aa), FASTA scores: opt: 405, FT E(): 6.5e-20, (41.9% identity in 155 aa overlap). Contains FT PS00374 Methylated-DNA--protein-cysteine methyltransferase FT active site." FT /db_xref="GOA:P0A697" FT /db_xref="HSSP:1SFE" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P0A697" FT /protein_id="CAD94210.1" FT /translation="MIHYRTIDSPIGPLTLAGHGSVLTNLRMLEQTYEPSRTHWTPDPG FT AFSGAVDQLNAYFAGELTEFDVELDLRGTDFQQRVWKALLTIPYGETRSYGEIADQIGA FT PGAARAVGLANGHNPIAIIVPCHRVIGASGKLTGYGGGINRKRALLELEKSRAPADLTL FT FD" FT CDS complement(161063..162313) FT /transl_table=11 FT /gene="alkAb" FT /locus_tag="Mb1350c" FT /product="PUTATIVE ADA REGULATORY PROTEIN ALKAb [SECOND FT PART] (Regulatory protein of adaptative response) : FT Methylated-DNA--protein-cysteine methyltransferase FT (O-6-methylguanine-DNA alkyltransferase)" FT /EC_number="2.1.1.63" FT /note="Mb1350c, alkAb, len: 416 aa. Equivalent to the 3' FT end of Rv1317c, len: 496 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100% identity in 416 aa FT overlap). Putative alkA (alternate gene name: ada), FT regulatory protein (EC 2.1.1.63), similar to FT 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from FT Escherichia coli (282 aa), FASTA scores, opt: 437, E(): FT 8.6e-22, (32.8% identity in 293 aa overlap), also similar FT to other ada proteins e.g. ADA_SALTY|P26189 Salmonella FT typhimurium (352 aa), FASTA scores: E(): 5.3e-08, (35.9% FT identity in 156 aa overlap). Contains PS00041 Bacterial FT regulatory proteins, araC family signature. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, alkA exists as a single gene. In FT Mycobacterium bovis, a single base transition (g-a) FT introduces a premature stop codon that splits alkA into 2 FT parts, alkAa and alkAb." FT /db_xref="GOA:Q7U082" FT /db_xref="HSSP:1DIZ" FT /db_xref="InterPro:IPR003583" FT /db_xref="UniProtKB/TrEMBL:Q7U082" FT /protein_id="CAD94211.1" FT /translation="MRSDVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERLLQAVV FT GAGPLALARAQRMQTARVLIETTNLPFGDVAFAAGFSSIRQFNDTVRLACDGTPTALRA FT RAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVRDGAYRRTLRLPW FT GNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALGADPDLRAV FT VGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGRPVHDRHGALTHTF FT PSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGP FT WTAEVIAMRGLGDPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLW FT TTLEHPVNQWPPQEKIA" FT CDS complement(162317..162553) FT /transl_table=11 FT /gene="alkAa" FT /locus_tag="Mb1351c" FT /product="PUTATIVE ADA REGULATORY PROTEIN ALKAa [FIRST FT PART] (Regulatory protein of adaptative response) : FT Methylated-DNA--protein-cysteine methyltransferase FT (O-6-methylguanine-DNA alkyltransferase)" FT /EC_number="2.1.1.63" FT /note="Mb1351c, alkAa, len: 78 aa. Equivalent to the 5' end FT of Rv1317c, len: 496 aa, from Mycobacterium tuberculosis FT strain H37Rv, (98.7% identity in 78 aa overlap). Putative FT alkA (alternate gene name: ada), regulatory protein (EC FT 2.1.1.63), similar to 3MG2_ECOLI|P04395 dna-3-methyladenine FT glycosidase II from Escherichia coli (282 aa), FASTA FT scores, opt: 437, E(): 8.6e-22, (32.8% identity in 293 aa FT overlap), also similar to other ada proteins e.g. FT ADA_SALTY|P26189 Salmonella typhimurium (352 aa), FASTA FT scores: E(): 5.3e-08, (35.9% identity in 156 aa overlap). FT Contains PS00041 Bacterial regulatory proteins, araC family FT signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, alkA exists as a single gene. In FT Mycobacterium bovis, a single base transition (g-a) FT introduces a premature stop codon that splits alkA into 2 FT parts, alkAa and alkAb." FT /db_xref="GOA:Q7U081" FT /db_xref="HSSP:1ADN" FT /db_xref="InterPro:IPR004026" FT /db_xref="UniProtKB/TrEMBL:Q7U081" FT /protein_id="CAD94212.1" FT /translation="MHDDFERCYRAVQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFA FT RNVRFLPTAAAAQGEGFRACKRCRPDASPGSPE" FT CDS complement(162634..164259) FT /transl_table=11 FT /gene="Mb1352c" FT /locus_tag="Mb1352c" FT /product="POSSIBLE ADENYLATE CYCLASE (ATP FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)" FT /EC_number="4.6.1.1" FT /note="Mb1352c, -, len: 541 aa. Equivalent to Rv1318c, len: FT 541 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 541 aa overlap). Possible adenylate cyclase (EC FT 4.6.1.1). Some similarity at the c-terminus to FT CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti FT (193 aa), FASTA scores, opt: 270, E(): 2.5e-11, (28.8% FT identity in 184 aa overlap); similar to other mycbacterium FT tuberculosis putative adenylate cyclases e.g. FT Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505, E(): FT 0, (71.0% identity in 534 aa overlap), also similar to FT Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E(): FT 0, (68.7% identity in 534 aa overlap). N-terminus is FT hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY." FT /db_xref="GOA:P63528" FT /db_xref="HSSP:1AWL" FT /db_xref="InterPro:IPR003660" FT /db_xref="UniProtKB/Swiss-Prot:P63528" FT /protein_id="CAD94213.1" FT /translation="MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRR FT RRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALA FT LGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGL FT INNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMV FT VWLLGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTAT FT PVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGR FT EVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDR FT HHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQV FT IAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGR FT HVKLRGHDQPVRLAKPVGLTKPRR" FT CDS complement(164329..165936) FT /transl_table=11 FT /gene="Mb1353c" FT /locus_tag="Mb1353c" FT /product="POSSIBLE ADENYLATE CYCLASE (ATP FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)" FT /EC_number="4.6.1.1" FT /note="Mb1353c, -, len: 535 aa. Equivalent to Rv1319c, len: FT 535 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 535 aa overlap). Possible adenylate cyclase (EC FT 4.6.1.1). Some similarity at the C-terminus to FT CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti FT (193 aa), FASTA scores: opt: 254, E(): 2.4e-10, (33.3% FT identity in 144 aa overlap); similar to other mycbacterium FT tuberculosis putative adenylate cyclases e.g. FT Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2505, E(): FT 0, (71.0% identity in 534 aa overlap); Rv1320c|MTCY130.05c FT (567 aa), FASTA scores: opt: 2354, E(): 0, (66.3% identity FT in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO FT ADENYLYL CYCLASE CLASS-3 FAMILY." FT /db_xref="GOA:P0A4Y3" FT /db_xref="InterPro:IPR003660" FT /db_xref="UniProtKB/Swiss-Prot:P0A4Y3" FT /protein_id="CAD94214.1" FT /translation="MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSR FT RWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALA FT IGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYG FT LANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTM FT TVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTA FT APVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVG FT REVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVD FT RHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQ FT IVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLG FT ETVTLRGHEQPTRLAVPT" FT CDS complement(165949..167652) FT /transl_table=11 FT /gene="Mb1354c" FT /locus_tag="Mb1354c" FT /product="POSSIBLE ADENYLATE CYCLASE (ATP FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)" FT /EC_number="4.6.1.1" FT /note="Mb1354c, -, len: 567 aa. Equivalent to Rv1320c, len: FT 567 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 567 aa overlap). Possible adenylate FT cyclase (EC 4.6.1.1) (see second citation below). Some FT similarity at the C-terminus to CYAA_RHIME|P19485 adenylate FT cyclase from Rhizobium meliloti (193 aa), FASTA scores: FT opt: 277, E(): 2e-12, (34.0% identity in 156 aa overlap); FT similar to other mycbacterium tuberculosis putative FT adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa), FASTA FT scores: opt: 2423, E(): 0, (68.7% identity in 534 aa FT overlap); Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: FT 2354, E(): 0, (66.3% identity in 534 aa overlap). FT N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE FT CLASS-3 FAMILY." FT /db_xref="GOA:P59972" FT /db_xref="InterPro:IPR003660" FT /db_xref="UniProtKB/Swiss-Prot:P59972" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94215.1" FT /translation="MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRM FT RRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI FT LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGL FT ANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTML FT VWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTAT FT PVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGR FT EVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNH FT HRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQV FT VAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGE FT TVTLRGHDQPIRLASPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD" FT CDS 167714..168394 FT /transl_table=11 FT /gene="Mb1355" FT /locus_tag="Mb1355" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1355, -, len: 226 aa. Equivalent to Rv1321, len: FT 226 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 226 aa overlap). Conserved hypothetical FT protein. Equivalent to P53524|YD21_MYCLE hypothetical FT protein from Mycobacterium leprae (201 aa), FASTA scores: FT opt: 1144, E(): 0, (87.6% identity in 193 aa overlap). Some FT similarity to hypothetical proteins from other organisms FT e.g. Y225_METJA|Q57678 Methanococcus jannaschii (263 aa), FT FASTA scores: E(): 6.5e-05, (25.0% identity in 212 aa FT overlap)." FT /db_xref="InterPro:IPR002793" FT /db_xref="UniProtKB/Swiss-Prot:P59979" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94216.1" FT /translation="MSRVRLVIAQCTVDYIGRLTAHLPSARRLLLFKADGSVSVHADDR FT AYKPLNWMSPPCWLTEESGGQAPVWVVENKAGEQLRITIEGIEHDSSHELGVDPGLVKD FT GVEAHLQALLAEHIQLLGEGYTLVRREYMTAIGPVDLLCRDERGGSVAVEIKRRGEIDG FT VEQLTRYLELLNRDSVLAPVKGVFAAQQIKPQARILATDRGIRCLTLDYDTMRGMDSGE FT YRLF" FT CDS 168417..168713 FT /transl_table=11 FT /gene="Mb1356" FT /locus_tag="Mb1356" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1356, -, len: 98 aa. Equivalent to Rv1322, len: 98 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 98 aa overlap). Conserved hypothetical FT protein." FT /db_xref="UniProtKB/Swiss-Prot:P64806" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94217.1" FT /translation="MARRRKPLHRQRPEPPSWALRRVEAGPDGHEYEVRPVAAARAVKT FT YRCPGCDHEIRSGTAHVVVWPTDLPQAGVDDRRHWHTPCWANRATRGPTRKWT" FT CDS complement(168748..169206) FT /transl_table=11 FT /gene="Mb1357c" FT /locus_tag="Mb1357c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1357c, -, len: 152 aa. Equivalent to Rv1322A, len: FT 152 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 152 aa overlap). Conserved hypothetical FT protein, similar to proteins from Mycobacterium leprae and FT Streptomyces coelicolor e.g. AL583921_2|ML1157 from M. FT leprae strain TN (155 aa), FASTA scores: opt: 771, E(): FT 5.1e-43, (75.3% identity in 154 aa overlap); and AL137242_2 FT from S. coelicolor (146 aa), FASTA scores: opt: 404, E(): FT 2e-19, (43.165% identity in 139 aa overlap)." FT /db_xref="HSSP:1JC5" FT /db_xref="InterPro:IPR017515" FT /db_xref="UniProtKB/TrEMBL:Q7U080" FT /protein_id="CAD94218.1" FT /translation="MMTTDQVHARHMLATSLVTGLDHVGIAVADLDVAIEWYHDHLGMI FT LVHEEINDDQGIREALLAVPGSAAQIQLMAPLDESSVIAKFLDKRGPGIQQLACRVSDL FT DAMCRRLRSQGVRLVYETARRGTANSRINFIHPKDAGGVLIELVEPAP" FT CDS 169297..170466 FT /transl_table=11 FT /gene="fadA4" FT /locus_tag="Mb1358" FT /product="PROBABLE ACETYL-COA ACETYLTRANSFERASE FADA4 FT (ACETOACETYL-COA THIOLASE)" FT /EC_number="2.3.1.9" FT /note="Mb1358, fadA4, len: 389 aa. Equivalent to Rv1323, FT len: 389 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 389 aa overlap). Probable fadA4, FT acetyl-CoA acetyltransferase (EC 2.3.1.9), equivalent to FT THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase FT from Mycobacterium leprae (393 aa), FASTA scores: opt: FT 2218, E(): 0, (87.0% identity in 392 aa overlap). Also FT highly similar to others e.g. CAB70629.1|AL137242 probable FT acetoacetyl-coA thiolase from Streptomyces coelicolor (401 FT aa); T51772 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) FT [validated] from Alcaligenes latus (392 aa); etc. Some FT homologies indicate ATA start codon. Contains PS00098 FT Thiolases acyl-enzyme intermediate signature, PS00737 FT Thiolases signature 2, and PS00099 Thiolases active site. FT BELONGS TO THE THIOLASE FAMILY." FT /db_xref="GOA:P66927" FT /db_xref="HSSP:1PXT" FT /db_xref="InterPro:IPR016038" FT /db_xref="UniProtKB/Swiss-Prot:P66927" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94219.1" FT /translation="MIVAGARTPIGKLMGSLKDFSASELGAIAIKGALEKANVPASLVE FT YVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGIDAIALADQLIRAREFD FT VVVAGGQESMTKAPHLLMNSRSGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQRNDV FT DMFTRSEQDEYAAASHQKAAAAWKDGVFADEVIPVNIPQRTGDPLQFTEDEGIRANTTA FT AALAGLKPAFRGDGTITAGSASQISDGAAAVVVMNQEKAQELGLTWLAEIGAHGVVAGP FT DSTLQSQPANAINKALDREGISVDQLDVVEINEAFAAVALASIRELGLNPQIVNVNGGA FT IAVGHPLGMSGTRITLHAALQLARRGSGVGVAALCGAGGQGDALILRAG" FT CDS 170596..171510 FT /transl_table=11 FT /gene="Mb1359" FT /locus_tag="Mb1359" FT /product="POSSIBLE THIOREDOXIN" FT /EC_number="1.-.-.-" FT /note="Mb1359, -, len: 304 aa. Equivalent to Rv1324, len: FT 304 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 304 aa overlap). Possible thioredoxin (EC FT 1.-.-.-), similar to several e.g. U00014|Q49716 TRXA from FT Mycobacterium leprae (255 aa), FASTA scores: opt: 1014, FT E(): 0, (69.7% identity in 228 aa overlap); FT THIO_RHOSH|P08058 TrxA from Rhodobacter sphaeroides (105 FT aa), FASTA scores: opt 196, E(): 1.9e-06, (33.0% identity FT in 103 aa overlap). Contains PS00339 Aminoacyl-transfer RNA FT synthetases class-II signature 2." FT /db_xref="GOA:P64808" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/Swiss-Prot:P64808" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94220.1" FT /translation="MTRPRPPLGPAMAGAVDLSGIKQRAQQNAAASTDADRALSTPSGV FT TEITEANFEDEVIVRSDEVPVVVLLWSPRSEVCVDLLDTLSGLAAAAKGKWSLASVNVD FT VAPRVAQIFGVQAVPTVVALAAGQPISSFQGLQPADQLSRWVDSLLSATAGKLKGAASS FT EESTEVDPAVAQARQQLEDGDFVAARKSYQAILDANPGSVEAKAAIRQIEFLIRATAQR FT PDAVSVADSLSDDIDAAFAAADVQVLNQDVSAAFERLIALVRRTSGEERTRVRTRLIEL FT FELFDPADPEVVAGRRNLANALY" FT CDS complement(171589..173400) FT /transl_table=11 FT /gene="PE_PGRS24" FT /locus_tag="Mb1360c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1360c, PE_PGRS24, len: 603 aa. Equivalent to FT Rv1325c, len: 603 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.8% identity in 603 aa overlap). Member of FT the Mycobacterium tuberculosis PE family, PGRS subfamily of FT ala-, gly-rich proteins, similar to many e.g. FT YQ04_MYCTU|P71933 hypothetical 63.1 kd glycine-rich protein FT (778 aa), FASTA scores: E(): 0, (52.3% identity in 724 aa FT overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U079" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94221.1" FT /translation="MSFVIAAPETLVRAASDLANIGSTLGAANAAALGPTTELLAAGAD FT EVSAAIASLFAAHGQAYQAVSAQMSAFHAQFVQTFTAGAGAYASAEAAAAAPLEGLLNI FT VNTPTQLLLGRPLIGNGANGAPGTGQAGGAGGLLYGNGGAGGSGAPGQAGGPGGAAGLF FT GNGGAGGAGGDGPGNGAAGGAGGAGGLLFGSGGAGGPGGVGNTGTGGLGGDGGAAGLFG FT AGGIGGAGGPGFNGGAGGAGGRSGLFEVLAAGGAGGTGGLSVNGGTGGTGGTGGGGGLF FT SNGGAGGAGGFGVSGSAGGNGGTGGDGGIFTGNGGTGGAGGTGTGNQLVGGEGGAGGAG FT GNAGILFGAGGIGGTGGTGLGAPDPGGTGGKGGVGGIGGAGALFGPGGAGGTGGFGASS FT ADQMAGGIGGSGGSGGAAKLIGDGGAGGTGGDSVRGAAGSGGTGGTGGLIGDGGAGGAG FT GTGIEFGSVGGAGGAGGNAAGLSGAGGAGGAGGFGETAGDGGAGGNAGLLNGDGGAGGA FT GGLGIAGDGGNGGKGGKAGMVGNGGDGGAGGASVVANGGVGGSGGNATLIGNGGNGGNG FT GVGSAPGKGGAGGTAGLLGLNGSPGLS" FT CDS complement(173552..175747) FT /transl_table=11 FT /gene="glgB" FT /locus_tag="Mb1361c" FT /product="PROBABLE 1,4-ALPHA-GLUCAN BRANCHING ENZYME GLGB FT (GLYCOGEN BRANCHING ENZYME)" FT /EC_number="2.4.1.18" FT /note="Mb1361c, glgB, len: 731 aa. Equivalent to Rv1326c, FT len: 731 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 731 aa overlap). Probable glgB, FT 1,4-alpha-glucan branching enzyme (EC 2.4.1.18), similar to FT others e.g. GLGB_ECOLI|P07762 Escherichia coli (728 aa), FT FASTA scores: opt: 2330, E(): 0, (48.7% identity in 719 aa FT overlap). Similar to other Mycobacterium tuberculosis FT putative alpha-glucan branching enzymes Rv1562c, Rv1563c. FT BELONGS TO FAMILY OF 13 GLYCOSYL HYDROLASES, ALSO KNOWN AS FT THE ALPHA-AMYLASE FAMILY." FT /db_xref="GOA:P59816" FT /db_xref="InterPro:IPR013783" FT /db_xref="UniProtKB/Swiss-Prot:P59816" FT /protein_id="CAD94222.1" FT /translation="MSRSEKLTGEHLAPEPAEMARLVAGTHHNPHGILGAHEYGDHTVI FT RAFRPHAVEVVALVGKDRFSLQHLDSGLFAVALPFVDLIDYRLQVTYEGCEPHTVADAY FT RFLPTLGEVDLHLFAEGRHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVSLIG FT EFNGWNGHEAPMRVLGPSGVWELFWPDFPCDGLYKFRVHGADGVVTDRADPFAFGTEVP FT PQTASRVTSSDYTWGDDDWMAGRALRNPVNEAMSTYEVHLGSWRPGLSYRQLARELTDY FT IVDQGFTHVELLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQAGIGVIV FT DWVPAHFPKDAWALGRFDGTPLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFLVANALYW FT LQEFHIDGLRVDAVASMLYLDYSRPEGGWTPNVHGGRENLEAVQFLQEMNATAHKVAPG FT IVTIAEESTSWPGVTRPTNIGGLGFSMKWNMGWMHDTLDYVSRDPVYRSYHHHEMTFSM FT LYAFSENYVLPLSHDEVVHGKGTLWGRMPGNNHVKAAGLRSLLAYQWAHPGKQLLFMGQ FT EFGQRAEWSEQRGLDWFQLDENGFSNGIQRLVRDINDIYRCHPALWSLDTTPEGYSWID FT ANDSANNVLSFMRYGSDGSVLACVFNFAGAEHRDYRLGLPRAGRWREVLNTDATIYHGS FT GIGNLGGVDATDDPWHGRPASAVLVLPPTSALWLTPA" FT CDS complement(175755..177860) FT /transl_table=11 FT /gene="glgE" FT /locus_tag="Mb1362c" FT /product="PROBABLE GLUCANASE GLGE" FT /note="Mb1362c, glgE, len: 701 aa. Equivalent to Rv1327c, FT len: 701 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 701 aa overlap). Probable glgE, FT glucanase, similar to AF172946|AF172946_2 putative FT glucanase GlgE from Mycobacterium smegmatis (697 aa), FASTA FT scores: opt: 3816, E(): 0, (78.5% identity in 692 aa FT overlap). Similar to putative alpha-amylases e.g. Q9L1K2 FT Streptomyces coelicolor (675 aa), FASTA scores: opt: 2243, FT E(): 7.4e-132, (54.2% identity in 684 aa overlap). Start FT changed since original submission (-36) based on similarity FT to GlgE of Mycobacterium smegmatis; previous start at FT position 1494531." FT /db_xref="GOA:P63532" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/Swiss-Prot:P63532" FT /protein_id="CAD94223.1" FT /translation="MSGRAIGTETEWWVPGRVEIDDVAPVVSCGVYPAKAVVGEVVPVS FT AAVWREGHEAVAATLVVRYLGVRYPHLTDRPRARVLPTPSEPQQRVKPLLIPMTSGQEP FT FVFHGQFTPDRVGLWTFRVDGWGDPIHTWRHGLIAKLDAGQGETELSNDLLVGAVLLER FT AATGVPRGLRDPLLAAAAALRTPGDPVTRTALALTPEIEELLADYPLRDLVTRGEQFGV FT WVDRPLARFGAWYEMFPRSTGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHP FT IGKVHRKGRNNSPTAAPTDVGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGME FT VALDLALQCAPDHPWAREHRQWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPEGLYDE FT VLRVVQHWVNHGVKFFRVDNPHTKPPNFWAWLIAQVKTVDPDVLFLSEAFTPPARQYGL FT AKLGFTQSYSYFTWRTTKWELTEFGNQIAELADYRRPNLFVNTPDILHAVLQHNGPGMF FT AIRAVLAATMSPAWGMYCGYELFEHRAVREGSEEYLDSEKYELRPRDFASALDQGRSLQ FT PFITRLNIIRRLHPAFQQLRTIHFHHVDNDALLAYSKFDPATGDCVLVVVTLNAFGPEE FT ATLWLDMAALGMEDYDRFWVRDEITGEEYQWGQANYIRIDPARAVAHIINMPAVPYESR FT NTLLRRR" FT CDS 177999..180590 FT /transl_table=11 FT /gene="glgP" FT /locus_tag="Mb1363" FT /product="PROBABLE GLYCOGEN PHOSPHORYLASE GLGP" FT /EC_number="2.4.1.1" FT /note="Mb1363, glgP, len: 863 aa. Equivalent to Rv1328, FT len: 863 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 863 aa overlap). Probable glgP, glycogen FT phosphorylase (EC 2.4.1.1), similar to many e.g. FT PHSG_HAEIN|P45180 glycogen phosphorylase from Haemophilus FT influenzae (821 aa), FASTA scores: E(): 6.9e-08, (25.6% FT identity in 675 aa overlap). BELONGS TO THE GLYCOGEN FT PHOSPHORYLASE FAMILY." FT /db_xref="GOA:Q7U078" FT /db_xref="InterPro:IPR000811" FT /db_xref="UniProtKB/Swiss-Prot:Q7U078" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94224.1" FT /translation="MKALRRFTVRAHLPERLAALDQLSTNLRWSWDKPTQDLFAAIDPA FT LWEQCGHDPVALLGAVNPARLDELALDAEFLGALDELAADLNDYLSRPLWYQEQQDAGV FT AAQALPTGIAYFSLEFGVAEVLPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRSGYF FT RQSLTADGWQHETYPSLDPQGLPLRLLTDANGDPVLVEVALGDNAVLRARIWVAQVGRV FT PLLLLDSDIPENEHDLRNVTDRLYGGDQEHRIKQEILAGIGGVRAIRAYTAVEKLTPPE FT VFHMNEGHAGFLGIERIRELVTDAGLDFDTALTVVRSSTVFTTHTPVPAGIDRFPLEMV FT QRYVNDQRGDGRSRLLPGLPADRIVALGAEDDPAKFNMAHMGLRLAQRANGVSLLHGRV FT SRAMFNELWAGFDPDEVPIGSVTNGVHAPTWAAPQWLQLGRELAGSDSLREPVVWQRLH FT QVDPAHLWWIRSQLRSMLVEDVRARLRQSWLERGATDAELGWIATAFDPNVLTVGFARR FT VPTYKRLTLMLRDPGRLEQLLLDEQRPIQLIVAGKSHPADDGGKALIQQVVRFADRPQF FT RHRIAFLPNYDMSMARLLYWGCDVWLNNPLRPLEACGTSGMKSALNGGLNLSIRDGWWD FT EWYDGENGWEIPSADGVADENRRDDLEAGALYDLLAQAVAPKFYERDERGVPQRWVEMV FT RHTLQTLGPKVLASRMVRDYVEHYYAPAAQSFRRTAGAQFDAARELADYRRRAEEAWPK FT IEIADVDSTGLPDTPLLGSQLTLTATVRLAGLRPNDVTVQGVLGRVDSGDVLMDPVTVE FT MAHTGTGDGGYEIFSTTTPLPLAGPVGYTVRVLPRHPMLAASNELGLVTLA" FT CDS complement(180630..182624) FT /transl_table=11 FT /gene="dinG" FT /locus_tag="Mb1364c" FT /product="PROBABLE ATP-DEPENDENT HELICASE DING HOMOLOG" FT /note="Mb1364c, dinG, len: 664 aa. Equivalent to Rv1329c, FT len: 664 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 664 aa overlap). Probable dinG, FT ATP-dependent helicase homolog, similar to several e.g. FT DING_HAEIN|P44680 probable ATP-dependent helicase ding from FT Haemophilus influenzae (640 aa), FASTA scores: opt: 685, FT E(): 2.3e-38, (32.8% identity in 644 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A." FT /db_xref="GOA:P64315" FT /db_xref="InterPro:IPR006555" FT /db_xref="UniProtKB/Swiss-Prot:P64315" FT /protein_id="CAD94225.1" FT /translation="MSESVSMSVPELLAIAVAALGGTRRRGQQEMAAAVAHAFETGEHL FT VVQAGTGTGKSLAYLVPAIIRALCDDAPVVVSTATIALQRQLVDRDLPQLVDSLTNALP FT RRPKFALLKGRRNYLCLNKIHNSVTASDHDDERPQEELFDPVAVTALGRDVQRLTAWAS FT TTVSGDRDDLKPGVGDRSWSQVSVSARECLGVARCPFGSECFSERARGAAGLADVVVTN FT HALLAIDAVAESAVLPEHRLLVVDEAHELADRVTSVAAAELTSATLGMAARRITRLVDP FT KVTQRLQAASATFSSAIHDARPGRIDCLDDEMATYLSALRDAASAARSAIDTGSDTTTA FT SVRAEAGAVLTEISDTASRILASFAPAIPDRSDVVWLEHEDNHESARAVLRVAPLSVAE FT LLATQVFARATTVLTSATLTIGGSFDAMATAWGLTADTPWRGLDVGSPFQHAKSGILYV FT AAHLPPPGRDGSGSAEQLTEIAELITAAGGRTLGLFSSMRAARAATEAMRERLSTPVLC FT QGDDSTSTLVEKFTADAATSLFGTLSLWQGVDVPGPSLSLVLIDRIPFPRPDDPLLSAR FT QRAVAARGGNGFMTVAASHAALLLAQGSGRLLRRVTDRGVVAVLDSRMATARYGEFLRA FT SLPPFWQTTNATQVRAALRRLARADAKAH" FT CDS complement(182648..183994) FT /transl_table=11 FT /gene="Mb1365c" FT /locus_tag="Mb1365c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1365c, -, len: 448 aa. Equivalent to Rv1330c, len: FT 448 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 448 aa overlap). Conserved hypothetical FT protein, similar to others and also several nicotinate FT phosphoribosyltransferases e.g. O32090 YUEK PROTEIN from FT Bacillus subtilis (490 aa), FASTA scores: E(): 8.6e-22, FT (37.9% identity in 369 aa overlap). Also similar to M. FT tuberculosis Rv0573c|MTV039.11c (38.0% identity in 437 aa FT overlap). Start changed since original submission based on FT similarity; previous start at position 1500740 (-61 aa)." FT /db_xref="GOA:Q7U077" FT /db_xref="InterPro:IPR015977" FT /db_xref="UniProtKB/TrEMBL:Q7U077" FT /protein_id="CAD94226.1" FT /translation="MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPT FT TFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFR FT GDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGR FT PLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHG FT GPTELAERAAFRAQVEALGPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVL FT ARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVY FT KLVEVDGVPVQKRSSYKKSPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTL FT PLVRAGQPVADTSLAAARQLVASGLRSLPADGLKLAPGEPAIPTRTIPA" FT CDS 184096..184401 FT /transl_table=11 FT /gene="Mb1366" FT /locus_tag="Mb1366" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1366, -, len: 101 aa. Equivalent to Rv1331, len: FT 101 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 101 aa overlap). Conserved hypothetical FT protein, highly similar to U00014|ML014 B1549_C2_207 from FT Mycobacterium leprae (94 aa), FASTA scores: opt: 573, E(): FT 2.9e-40, (90.3% identity in 93 aa overlap). Similar to FT AL096852|SCE19A_16 hypothetical protein from Streptomyces FT coelicolor (105 aa), FASTA scores: opt: 377, E(): 2.9e-22, FT (60.0% identity in 105 aa overlap)." FT /db_xref="GOA:P67648" FT /db_xref="HSSP:1MBX" FT /db_xref="InterPro:IPR014719" FT /db_xref="UniProtKB/Swiss-Prot:P67648" FT /protein_id="CAD94227.1" FT /translation="MAVVSAPAKPGTTWQRESAPVDVTDRAWVTIVWDDPVNLMSYVTY FT VFQKLFGYSEPHATKLMLQVHNEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR" FT CDS 184361..185017 FT /transl_table=11 FT /gene="Mb1367" FT /locus_tag="Mb1367" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1367, -, len: 218 aa. Equivalent to Rv1332, len: FT 218 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 218 aa overlap). Possible regulatory protein, FT high similarity to ML014|U00014 from Mycobacterium leprae FT B1549_C3_236 (222 aa), FASTA scores: opt: 1158, E(): 0, FT (75.6% identity in 221 aa overlap). Helix turn helix motif FT fram aa 8-29 (+3.03 SD)." FT /db_xref="InterPro:IPR018561" FT /db_xref="UniProtKB/Swiss-Prot:P64810" FT /protein_id="CAD94228.1" FT /translation="MPPVCGRRCSRTGEIRGYSGSIVRRWKRVETRDGPRFRSSLAPHE FT AALLKNLAGAMIGLLDDRDSSSPSDELEEITGIKTGHAQRPGDPTLRRLLPDFYRPDDL FT DDDDPTAVDGSESFNAALRSLHEPEIIDAKRVAAQQLLDTVPDNGGRLELTESDANAWI FT AAVNDLRLALGVMLEIGPRGPERLPGNHPLAAHFNVYQWLTVLQEYLVLVLMGSR" FT CDS 185034..186068 FT /transl_table=11 FT /gene="Mb1368" FT /locus_tag="Mb1368" FT /product="PROBABLE HYDROLASE" FT /EC_number="3.-.-.-" FT /note="Mb1368, -, len: 344 aa. Equivalent to Rv1333, len: FT 344 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 344 aa overlap). Possible hydrolase (EC FT 3.-.-.-), similar to Q57326|D26094 endo-type FT 6-aminohexanoate oligomer hydrolase (355 aa), fasta scores: FT E(): 1.4e-10, (31.9% identity in 339 aa overlap). FT Equivalent to P53425|YD33_MYCLE HYPOTHETICAL 36.1 KD FT PROTEIN B154 Mycobacterium leprae (362 aa), FASTA scores: FT opt: 1735, E(): 0, (76.7% identity in 352 aa overlap)." FT /db_xref="GOA:P64812" FT /db_xref="InterPro:IPR005321" FT /db_xref="UniProtKB/Swiss-Prot:P64812" FT /protein_id="CAD94229.1" FT /translation="MNSITDVGGIRVGHYQRLDPDASLGAGWACGVTVVLPPPGTVGAV FT DCRGGAPGTRETDLLDPANSVRFVDALLLAGGSAYGLAAADGVMRWLEEHRRGVAMDSG FT VVPIVPGAVIFDLPVGGWNCRPTADFGYSACAAAGVDVAVGTVGVGVGARAGALKGGVG FT TASATLQSGVTVGVLAVVNAAGNVVDPATGLPWMADLVGEFALRAPPAEQIAALAQLSS FT PLGAFNTPFNTTIGVIACDAALSPAACRRIAIAAHDGLARTIRPAHTPLDGDTVFALAT FT GAVAVPPEAGVPAALSPETQLVTAVGAAAADCLARAVLAGVLNAQPVAGIPTYRDMFPG FT AFGS" FT CDS 186076..186516 FT /transl_table=11 FT /gene="Mb1369" FT /locus_tag="Mb1369" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1369, -, len: 146 aa. Equivalent to Rv1334, len: FT 146 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 146 aa overlap). Conserved hypothetical FT protein, similar to AL096852|SCE19A_13 hypothetical protein FT from Streptomyces coelicolor (140 aa), Fasta scores: opt: FT 579, E(): 0, (65.0% identity in 140 aa overlap); and FT Q54330|M29166 MEC+ from Streptomyces kasugaensis (115 aa), FT FASTA scores; E(): 7.6e-33, (56.9% identity in 109 aa FT overlap)." FT /db_xref="InterPro:IPR000555" FT /db_xref="UniProtKB/Swiss-Prot:P64814" FT /protein_id="CAD94230.1" FT /translation="MLLRKGTVYVLVIRADLVNAMVAHARRDHPDEACGVLAGPEGSDR FT PERHIPMTNAERSPTFYRLDSGEQLKVWRAMEDADEVPVVIYHSHTATEAYPSRTDVKL FT ATEPDAHYVLVSTRDPHRHELRSYRIVDGAVTEEPVNVVEQY" FT CDS 186538..186819 FT /transl_table=11 FT /gene="Mb1370" FT /locus_tag="Mb1370" FT /product="9.5 KDA CULTURE FILTRATE ANTIGEN CFP10A" FT /note="Mb1370, -, len: 93 aa. Equivalent to Rv1335, len: 93 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 93 aa overlap). 9.5 kDa culture filtrate FT antigen cfp10A (see citation below). Similar to FT hypothetical proteins from other organisms e.g. FT P74060|D90911 Synechocystis (109 aa), FASTA scores: E(): FT 2.3e-20, (49.5% identity in 93 aa overlap)." FT /db_xref="GOA:P0A647" FT /db_xref="InterPro:IPR003749" FT /db_xref="UniProtKB/Swiss-Prot:P0A647" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94231.1" FT /translation="MNVTVSIPTILRPHTGGQKSVSASGDTLGAVISDLEANYSGISER FT LMDPSSPGKLHRFVNIYVNDEDVRFSGGLATAIADGDSVTILPAVAGG" FT CDS 186829..187800 FT /transl_table=11 FT /gene="cysM" FT /locus_tag="Mb1371" FT /product="PROBABLE CYSTEINE SYNTHASE B CYSM (CSASE B) FT (O-acetylserine sulfhydrylase B) (O-acetylserine FT (Thiol)-lyase B)" FT /EC_number="2.5.1.47" FT /note="Mb1371, cysM, len: 323 aa. Equivalent to Rv1336, FT len: 323 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 323 aa overlap). Probable cysM, cysteine FT synthase B (EC 4.2.99.8), similar to many e.g. FT CYSM_ECOLI|P16703 Escherichia coli (303 aa), FASTA scores: FT opt: 720, E(): 4.6e-40, (41.1% identity in 302 aa overlap). FT Also similar to other Mycobacterium tuberculosis cysteine FT synthase subunits e.g. Rv1077, Rv2334, Rv0848, etc. FT Contains PS00901 Cysteine synthase/cystathionine FT beta-synthase P-phosphate attachment site. BELONGS TO THE FT CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY." FT /db_xref="GOA:P63874" FT /db_xref="HSSP:1JBQ" FT /db_xref="InterPro:IPR005856" FT /db_xref="UniProtKB/Swiss-Prot:P63874" FT /protein_id="CAD94232.1" FT /translation="MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRN FT PTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPEN FT TSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYC FT GTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNM FT DEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGAL FT AAGERADIALVVADAGWKYLSTGAYAGSLDDAETALEGQLWA" FT CDS 187791..188513 FT /transl_table=11 FT /gene="Mb1372" FT /locus_tag="Mb1372" FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT /note="Mb1372, -, len: 240 aa. Equivalent to Rv1337, len: FT 240 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 240 aa overlap). Probable integral membrane FT protein. Highly similar to P53426 hypothetical protein FT B1549_C3_240 from M.leprae (251); and P74553|D90916 FT hypothetical protein from Synechocystis sp. (198 aa), FASTA FT scores: E(): 2.3e-25, (43.6% identity in 181 aa overlap)." FT /db_xref="GOA:P64816" FT /db_xref="InterPro:IPR002610" FT /db_xref="UniProtKB/Swiss-Prot:P64816" FT /protein_id="CAD94233.1" FT /translation="MGMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILT FT FVALLYLVELIDQLSGSRLDVNGIRPLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLG FT FLMTLAGLSRFVWATAIIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLLVFG FT LFVRKGWDIVIGLVVLFVYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPE FT RKARALKRAGARSGHPKL" FT CDS 188510..189325 FT /transl_table=11 FT /gene="murI" FT /locus_tag="Mb1373" FT /product="PROBABLE GLUTAMATE RACEMASE MURI" FT /EC_number="5.1.1.3" FT /note="Mb1373, murI, len: 271 aa. Equivalent to Rv1338, FT len: 271 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 271 aa overlap). Probable murI, glutamate FT racemase (EC 5.1.1.3), highly similar to many e.g. FT MURI_MYCLE|P46705 (272 aa), FASTA scores: opt: 1559, E(): FT 0, (88.9% identity in 271 aa overlap). Contains PS00924 FT Aspartate and glutamate racemases signature 2." FT /db_xref="GOA:P63636" FT /db_xref="HSSP:1B74" FT /db_xref="InterPro:IPR004391" FT /db_xref="UniProtKB/Swiss-Prot:P63636" FT /protein_id="CAD94234.1" FT /translation="MNSPLAPVGVFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYG FT PLTIPEIRAHALAIGDDLVGRGVKALVIACNSASSACLRDARERYQVPVVEVILPAVRR FT AVAATRNGRIGVIGTRATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGRQVL FT GLAQGYLEPLQRAEVDTLVLGCTHYPLLSGLIQLAMGENVTLVSSAEETAKEVVRVLTE FT IDLLRPHDAPPATRIFEATGDPEAFTKLAARFLGPVLGGVQPVHPSRIH" FT CDS 189352..190173 FT /transl_table=11 FT /gene="Mb1374" FT /locus_tag="Mb1374" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1374, -, len: 273 aa. Equivalent to Rv1339, len: FT 273 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 273 aa overlap). Conserved hypothetical FT protein, highly similar to Y211_MYCLE|P50474 hypothetical FT protein b1549_c2_211 from Mycobacterium leprae (284 aa), FT FASTA scores: opt: 1672, E(): 0, (86.2% identity in 276 aa FT overlap). Also similar to AL096852|SCE19A.08 hypothetical FT protein from Streptomyces coelicolor (250 aa), FASTA FT scores: opt: 630, E(): 0, (42.2% identity in 256 aa FT overlap). Similar to Mycobacterium tuberculosis FT hypothetical proteins Rv3796, Rv2407." FT /db_xref="UniProtKB/Swiss-Prot:P66874" FT /protein_id="CAD94235.1" FT /translation="MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAPH FT TPPLVIDFGGGVLGALQRHADPASVHVLLSHLHADHCLDLPGLFVWRRYHPSRPSGKAL FT LYGPSDTWSRLGAASSPYGGEIDDCSDIFDVHHWADSEPVTLGALTIVPRLVAHPTESF FT GLRITDPSGASLAYSGDTGICDQLVELARGVDVFLCEASWTHSPKHPPDLHLSGTEAGM FT VAAQAGVRELLLTHIPPWTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG" FT CDS 190190..190969 FT /transl_table=11 FT /gene="rphA" FT /locus_tag="Mb1375" FT /product="PROBABLE RIBONUCLEASE RPHA (RNase PH) (tRNA FT nucleotidyltransferase)" FT /EC_number="2.7.7.56" FT /note="Mb1375, rphA, len: 259 aa. Equivalent to Rv1340, FT len: 259 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 259 aa overlap). Probable rphA, FT Ribonuclease ph (EC 2.7.7.56), highly similar to others FT e.g. RNPH_MYCLE|P37939 from Mycobacterium leprae (259 aa), FT FASTA scores: opt: 1524, E(): 0, (88.8% identity in 259 aa FT overlap). BELONGS TO THE RNASE PH FAMILY." FT /db_xref="GOA:Q7U076" FT /db_xref="HSSP:1R6L" FT /db_xref="InterPro:IPR002381" FT /db_xref="UniProtKB/Swiss-Prot:Q7U076" FT /protein_id="CAD94236.1" FT /translation="MSKREDGRLDHELRPVIITRGFTENPAGSVLIEFGHTKVLCTASV FT TEGVPRWRKATGLGWLTAEYAMLPSATHSRSDRESVRGRLSGRTQEISRLISRSLRACI FT DLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLSAAGKLSDPRPLSCAIA FT AVSVGVVDGRIRVDLPYEEDSRAEVDMNVVATDTGTLVEIQGTGEGATFARSTLDKLLD FT MALGACDTLFAAQRDALALPYPGVLPQGPPPPKAFGT" FT CDS 191008..191622 FT /transl_table=11 FT /gene="Mb1376" FT /locus_tag="Mb1376" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1376, -, len: 204 aa. Equivalent to Rv1341, len: FT 204 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 204 aa overlap). Conserved hypothetical FT protein, equivalent to ML014|U00014 hypothetical protein FT B1549_C2_213 from Mycobacterium leprae (285 aa), FASTA FT scores: opt: 1073, E(): 0, (83.0% identity in 206 aa FT overlap). Some similarity to P52061|YGGV_ECOLI HYPOTHETICAL FT PROTEIN yggV (197 aa), FASTA scores: opt: 521, E(): FT 7.9e-27, (46.0% identity in 200 aa overlap)." FT /db_xref="GOA:P64308" FT /db_xref="InterPro:IPR002637" FT /db_xref="UniProtKB/Swiss-Prot:P64308" FT /protein_id="CAD94237.1" FT /translation="MALVTKLLVASRNRKKLAELRRVLDGAGLSGLTLLSLGDVSPLPE FT TPETGVTFEDNALAKARDAFSATGLASVADDSGLEVAALGGMPGVLSARWSGRYGDDAA FT NTALLLAQLCDVPDERRGAAFVSACALVSGSGEVVVRGEWPGTIAREPRGDGGFGYDPV FT FVPYGDDRTAAQLSPAEKDAVSHRGRALALLLPALRSLATG" FT CDS complement(191619..191981) FT /transl_table=11 FT /gene="Mb1377c" FT /locus_tag="Mb1377c" FT /product="CONSERVED MEMBRANE PROTEIN" FT /note="Mb1377c, -, len: 120 aa. Equivalent to Rv1342c, len: FT 120 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 120 aa overlap). Conserved membrane protein. FT Highly similar to G466926|P54133 hypothetical protein FT B1549_F2_59 from Mycobacterium leprae (119 aa), FASTA FT scores, opt: 544, E(): 1.9e-29, (68.3 % identity in 120 aa FT overlap)." FT /db_xref="GOA:P0A5E8" FT /db_xref="UniProtKB/Swiss-Prot:P0A5E8" FT /protein_id="CAD94238.1" FT /translation="MTAPETPAAQHAEPAIAVERIRTALLGYRIMAWTTGLWLIALCYE FT IVVRYVVKVDNPPTWIGVVHGWVYFTYLLLTLNLAVKVRWPLGKTAGVLLAGTIPLLGI FT VVEHFQTKEIKARFGL" FT CDS complement(191978..192358) FT /transl_table=11 FT /gene="lprD" FT /locus_tag="Mb1378c" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRD" FT /note="Mb1378c, lprD, len: 126 aa. Equivalent to Rv1343c, FT len: 126 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 126 aa overlap). Probable lprD, FT conserved lipoprotein, highly similar to G466928 FT Mycobacterium leprae protein B1549_F3_106 (126 aa), FASTA FT scores, opt: 704, E(): 7.5e-36, (78.4 % identity in 125 aa FT overlap). Has N-terminal signal sequence and appropriately FT positioned prokaryotic lipoprotein attachment site. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="UniProtKB/TrEMBL:Q7U075" FT /protein_id="CAD94239.1" FT /translation="MSTTRRRRPALIALVIIATCGCLALGWWQWTRFQSTSGTFQNLGY FT ALQWPLFAWFCVYAYRNFVRYEETPPQPPTGGAAAAIPAGLLPERPKPAQQPPDDPVLR FT EYNAYLAELAKDDARKQNRTTA" FT CDS 192403..192723 FT /transl_table=11 FT /gene="Mb1379" FT /locus_tag="Mb1379" FT /product="PROBABLE ACYL CARRIER PROTEIN (ACP)" FT /note="Mb1379, -, len: 106 aa. Equivalent to Rv1344, len: FT 106 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 106 aa overlap). Possible acyl carrier protein, FT similar to others e.g. ACP_RHIME|P19372 Rhizobium meliloti FT (77 aa), FASTA scores: opt: 117, E(): 0.03, (29.9% identity FT in 67 aa overlap) and ACP_SYNY3|P20804 acyl carrier protein FT (acp) from Synechocystis sp (77 aa), FASTA scores: E(): FT 7.1e-05, (34.8% identity in 66 aa overlap). Also similar to FT Rv2244 and Rv0033 from Mycobacterium tuberculosis." FT /db_xref="GOA:P63453" FT /db_xref="InterPro:IPR006162" FT /db_xref="UniProtKB/Swiss-Prot:P63453" FT /protein_id="CAD94240.1" FT /translation="MWRYPLSTRLALPNTPGVASFAMTSSPSTVSTTLLSILRDDLNID FT LTRVTPDARLVDDVGLDSVAFAVGMVAIEERLGVALSEEELLTCDTVGELEAAIAAKYR FT DE" FT CDS 192716..194281 FT /transl_table=11 FT /gene="fadD33" FT /locus_tag="Mb1380" FT /product="POSSIBLE POLYKETIDE SYNTHASE FADD33" FT /note="Mb1380, fadD33, len: 521 aa. Equivalent to Rv1345, FT len: 521 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 521 aa overlap). Possible fadD33, FT polyketide synthase, similar to N-terminus of T34918 FT polyketide synthase from Streptomyces coelicolor (2297 aa); FT and PKSJ_BACSU|P40806 putative polyketide biosynthesis FT protein from Bacillus subtilis (557 aa), FASTA scores: opt: FT 537, E(): 8.2e-27, (27.1% identity in 468 aa overlap). Also FT similar to other proteins from Mycobacterium tuberculosis FT eg Rv1013|MTCI237.30|MTCY10G2.36c|pks16 PUTATIVE POLYKETIDE FT SYNTHASE (544 aa); etc." FT /db_xref="GOA:P0A4X9" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/Swiss-Prot:P0A4X9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94241.1" FT /translation="MSELAAVLTRSMQASAGDLMVLDRETSLWCRHPWPEVHGLAESVA FT AWLLDHDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGANDQRWADATLTRF FT LGIGVRTVLSQGSYLARLRSVDTAGVTIGDLSTAAHTNRSATPVASEGPAVLQGTAGST FT GAPRTAILSPGAVLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLAFVLSAALAGAPLW FT LAPTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARRVSEVDLGALRVTLNGGE FT PVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPGIGLLADRVIDGSGAHK FT HAVLGNPIPGMEVRISCGDQAAGNASREIGEIEIRGASMMAGYLGQQPIDPDDWFATGD FT LGYLGAGGLVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDRSTRPG FT LVVAAEFRGPDEANARAELIQRVASECGIVPSDVVFVSPGSLPRTSSGKLRRLAVRRSL FT EMAD" FT CDS 194281..195441 FT /transl_table=11 FT /gene="fadE14" FT /locus_tag="Mb1381" FT /product="POSSIBLE ACYL-COA DEHYDROGENASE FADE14" FT /EC_number="1.3.99.-" FT /note="Mb1381, fadE14, len: 386 aa. Equivalent to Rv1346, FT len: 386 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 386 aa overlap). Possible fadE14, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT NP_251579.1|NC_002516 probable acyl-CoA dehydrogenase from FT Pseudomonas aeruginosa (386 aa); FT NP_036951.1|NM_012819|ACDL_RAT|P15650 acyl Coenzyme A FT dehydrogenase (long chain) from Rattus norvegicus (430 aa), FT FASTA scores: opt: 414, E(): 1.2e-18, (26.1% identity in FT 376 aa overlap); etc." FT /db_xref="GOA:P63432" FT /db_xref="InterPro:IPR013764" FT /db_xref="UniProtKB/Swiss-Prot:P63432" FT /protein_id="CAD94242.1" FT /translation="MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLGV FT CGVFDAKWATDARPDVGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYLRD FT ICDQAIRGAAVLCIGASEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMV FT VARSVDHDPTSRHGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCIDTWVPADALVAR FT AGTGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQALRLRMA FT DLQARVDLLRYALHGIAEQGRLELRTAAAVKVTAARLGEEVISECMHIFGGAGYLVDET FT TLGKWWRDMKLARVGGGTDEVLWELVAAGMTPDHDGYAAVVGASKA" FT CDS complement(195408..196040) FT /transl_table=11 FT /gene="Mb1382c" FT /locus_tag="Mb1382c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1382c, -, len: 210 aa. Equivalent to Rv1347c, len: FT 210 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 210 aa overlap). Conserved hypothetical FT protein, some similarity to the C-terminus of FT malonyl-coenzyme A carboxylases e.g. G545170 FT malonyl-coenzyme A carboxylase (417 aa), FASTA scores: opt: FT 392, E(): 4.9 e-20, (35.6% identity in 174 aa overlap)." FT /db_xref="GOA:P64820" FT /db_xref="InterPro:IPR019432" FT /db_xref="UniProtKB/Swiss-Prot:P64820" FT /protein_id="CAD94243.1" FT /translation="MTKPTSAGQADDALVRLARERFDLPDQVRRLARPPVPSLEPPYGL FT RVAQLTDAEMLAEWMNRPHLAAAWEYDWPASRWRQHLNAQLEGTYSLPLIGSWHGTDGG FT YLELYWAAKDLISHYYDADPYDLGLHAAIADLSKVNRGFGPLLLPRIVASVFANEPRCR FT RIMFDPDHRNTATRRLCEWAGCKFLGEHDTTNRRMALYALEAPTTAA" FT tRNA 196163..196246 FT /gene="leuW" FT /locus_tag="leuW" FT /note="leuW, len: 84 nt. Equivalent to leuW, len: 84 nt, FT from Mycobacterium tuberculosis strain H37RV, (100.0% FT identity in 84 nt overlap). tRNA-Leu, anticodon tag." FT CDS 196482..199061 FT /transl_table=11 FT /gene="Mb1383" FT /locus_tag="Mb1383" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /note="Mb1383, -, len: 859 aa. Equivalent to Rv1348, len: FT 859 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 859 aa overlap). Probable drugs-transport FT transmembrane protein ATP binding protein ABC transporter FT (see citation below), similar to HMT1_SCHPO|Q02592 heavy FT metal tolerance protein precursor from Schizosaccharomyces FT pombe (830 aa), FASTA scores: opt: 806, E(): 5.1e-39, FT (32.9% identity in 504 aa overlap); etc. Also similar to FT MTCY02B10.13 from Mycobacterium tuberculosis, FASTA score: FT (31.9% identity in 576 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), and PS00211 ABC FT transporters family signature. BELONGS TO THE ATP-BINDING FT TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:P63392" FT /db_xref="HSSP:1JJ7" FT /db_xref="InterPro:IPR007037" FT /db_xref="UniProtKB/Swiss-Prot:P63392" FT /protein_id="CAD94244.1" FT /translation="MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQD FT AEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTV FT KPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQH FT DDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLR FT DEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQA FT ASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVGFAAVGL FT LGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTL FT ALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPR FT IVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTL FT MDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTG FT LLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRP FT GTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQ FT LVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVLGANSGLSGGERQR FT LTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQ FT IVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQDGTR" FT CDS 199058..200797 FT /transl_table=11 FT /gene="Mb1384" FT /locus_tag="Mb1384" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /note="Mb1384, -, len: 579 aa. Equivalent to Rv1349, len: FT 579 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 579 aa overlap). Probable drugs-transport FT transmembrane ATP binding protein ABC transporter (see FT citation below), most similar to YWJA_BACSU|P45861 FT hypothetical ABC transporter from Bacillus subtilis (575 FT aa), FASTA scores: opt: 721, E(): 1.8e-35, (28.9% identity FT in 567 aa overlap); etc. Also similar to MTCY02B10.12 from FT Mycobacterium tuberculosis, FASTA score: (31.9% identity in FT 576 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop), and PS00211 ABC transporters family FT signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FT FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:P63394" FT /db_xref="HSSP:1MT0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P63394" FT /protein_id="CAD94245.1" FT /translation="MIRTWIALVPNDHRARLIGFALLAFCSVVARAVGTVLLVPLMAAL FT FGEAPQRAWLWLGWLSAATVAGWVLDAVTARIGIELGFAVLNHTQHDVADRLPVVRLDW FT FTAENTATARQAIAATGPELVGLVVNLVTPLTSAILLPAVIALALLPISWQLGVAALAG FT VPLLLGALWASAAFARRADTAADKANTALTERIIEFARTQQALRAARRVEPARSLVGNA FT LASQHTATMRLLGMQIPGQLLFSIASQLALIVLAGTTAALTITGTLTVPEAIALIVVMV FT RYLEPFTAVSELAPALESTRATLGRIGSVLTAPVMVAGSGTWRDGAVVPRIEFDDVAFG FT YDGGSGPVLDGVSFCLQPGTTTAIVGPSGCGKSTILALIAGLHQPTRGRVLIDGTDVAT FT LDARAQQAVCSVVFQHPYLFHGTIRDNVFAADPGASDDQFAQAVRLARVDELIARLPDG FT ANTIVGEAGSALSGGERQRVSIARALLKAAPVLLVDEATSALDAENEAAVVDALAADPR FT SRTRVIVAHRLASIRHADRVLFVDDGRVVEDGSISELLTAGGRFSQFWRQQHEAAEWQI FT LAE" FT CDS 200926..201669 FT /transl_table=11 FT /gene="fabG2" FT /locus_tag="Mb1385" FT /product="PUTATIVE 3-OXOACYL-[ACYL-CARRIER PROTEIN] FT REDUCTASE FABG2 (3-KETOACYL-ACYL CARRIER PROTEIN FT REDUCTASE)" FT /EC_number="1.1.1.100" FT /note="Mb1385, fabG2, len: 247 aa. Equivalent to Rv1350, FT len: 247 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 247 aa overlap). Probable fabG2, FT 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100), FT highly similar to many e.g. NP_350157.1|NC_003030 FT 3-ketoacyl-acyl carrier protein reductase from Clostridium FT acetobutylicum (249 aa); NP_229523.1|NC_000853 FT 3-oxoacyl-(acyl carrier protein) reductase from Thermotoga FT maritima (246 aa); AAC44307.1|U59433 3-ketoacyl-acyl FT carrier protein reductase from Bacillus subtilis (246 aa); FT etc. Contains PS00061 Short-chain dehydrogenases/reductases FT family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:P66782" FT /db_xref="HSSP:1FK8" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P66782" FT /protein_id="CAD94246.1" FT /translation="MASLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEATE FT VAAKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTMTE FT EQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKAGIV FT GMTKAAAKELAHLGIRVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASV FT AVFLASDLSSYMTGTVLDVTGGRFI" FT CDS 201666..201995 FT /transl_table=11 FT /gene="Mb1386" FT /locus_tag="Mb1386" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1386, -, len: 109 aa. Equivalent to Rv1351, len: FT 109 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 109 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64822" FT /protein_id="CAD94247.1" FT /translation="MTPRSLPRYGNSSRRKSFPMHRPSNVATATRKKSSIGWVLLACSV FT AGCKGIDTTEFILGRAGAFELAVRAAQHRHRYLTMVNVGRAPPRRCRTVCMAATDTPRN FT IRLNG" FT CDS 202198..202569 FT /transl_table=11 FT /gene="Mb1387" FT /locus_tag="Mb1387" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1387, -, len: 123 aa. Equivalent to Rv1352, len: FT 123 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 123 aa overlap). Conserved hypothetical FT protein, some similarity to Rv1906c|MTCY180.12 hypothetical FT protein from Mycobacterium tuberculosis (156 aa), FASTA FT scores: E(): 4e-05, (36.2% identity in 116 aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64824" FT /protein_id="CAD94248.1" FT /translation="MARTLALRASAGLVAGMAMAAITLAPGARAETGEQFPGDGVFLVG FT TDIAPGTYRTEGPSNPLILVFGRVSELSTCSWSTHSAPEVSNENIVDTNTSMGPMSVVI FT PPTVAAFQTHNCKLWMRIS" FT CDS complement(202635..203420) FT /transl_table=11 FT /gene="Mb1388c" FT /locus_tag="Mb1388c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1388c, -, len: 261 aa. Equivalent to Rv1353c, len: FT 261 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 261 aa overlap). Probable transcriptional FT regulatory protein, similar to TER1_ECOLI|P03038 FT tetracycline repressor protein class A from Escherichia FT coli (216 aa), FASTA scores, opt: 231, E(): 1.6e-08, (31.3% FT identity in 211 aa overlap). Helix turn helix motif present FT at aa 3859 (+3.59 SD). BELONGS TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:P67435" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/Swiss-Prot:P67435" FT /protein_id="CAD94249.1" FT /translation="MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKH FT LGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFAD FT NPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVV FT LDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILD FT HAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR" FT CDS complement(203440..205311) FT /transl_table=11 FT /gene="Mb1389c" FT /locus_tag="Mb1389c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1389c, -, len: 623 aa. Equivalent to Rv1354c, len: FT 623 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 623 aa overlap). Conserved hypothetical FT protein, similar to many hypothetical proteins e.g. the FT C-terminus of G1001455 Synechocystis sp. (1244 aa), FASTA FT scores: opt: 933, E(): 0, (36.8% identity in 462 aa FT overlap); also similar to Rv1357c|MTCY02B10.21c (34.0% FT identity in 253 aa overlap)." FT /db_xref="InterPro:IPR003018" FT /db_xref="UniProtKB/Swiss-Prot:P64826" FT /protein_id="CAD94250.1" FT /translation="MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG FT VDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLVFR FT PEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTI FT ATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLDLD FT RLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPL FT AERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSV FT AIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTR FT GLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTG FT GFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGY FT SAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAA FT RILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS" FT CDS complement(205320..207467) FT /transl_table=11 FT /gene="moeY" FT /locus_tag="Mb1390c" FT /product="POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY" FT /note="Mb1390c, moeY, len: 715 aa. Equivalent to Rv1355c, FT len: 715 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 715 aa overlap). Possible moeY, FT Molybdopterin biosynthesis protein, very weak similarity to FT MOEB_ECOLI|P12282 molybdopterin biosynthesis moeb protein FT (249 aa), FASTA scores, opt: 180, E(): 8.5e-05, (29.3% FT identity in 174 aa overlap)." FT /db_xref="GOA:Q7U074" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U074" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94251.1" FT /translation="MTIPHEGGSTGILVLRDDDHDDVLVLDRLRSDPSIEFVDRFAEQL FT AGVRRLLPQPDPDLLEEAKRWAYYPWRRMVVAILGPRGFRAVRLDRNRHLITAEEQRAL FT HALRVGVVGLSAGHAIAYTLAAEGACGTLRLADFDKIELSNLNRVPVGVFDIGLNKAMI FT AARRIAELDPYLAVDLVTSGLSPESVDEFLDGLDVVIEECDSLDIKVILRQAACARGVP FT VLMATSDRGLVDVERYDVEPGRPIFHGLLGDIDADKLCGLTTKDKVPHVLNILDCQELS FT ARCAASMIEVDQTLWGWPQLAGDIWVGAATVAEAVRRIGLGEPLESGRVRVDVSAALDR FT LDQPPMPSRGNGWLLESVPPTAPAEPQPTSEIVAQAAIRAPSGGNVQPWHVVAKQHSLT FT IRLAPEHTSAMDIAFRGSAVAVGAAMFNARVAAAAHRVLGSVEFDESQPDSPLQATMHF FT GRGDDPSLAALYRPMLLRTTNRHHGMPGHVHPATVELLTNTAAAEGARLQLLLSRNEID FT RAATILAAADRIRYLTPRLHEEMMSELRWPGDPSLDAGIDVRSLELDSGELRVLDILRR FT SDVVARLAQWDCGTALEDNTNERVSASSALAIVYVDGATLTDFARGGSAMQAVWIVAQQ FT HGLAVQPMSPIFLYARGRHDLDQASPHFAAQLHRLQLDFRELVKPGKEGHEVLIFRLFH FT APPPSVCSRRRVRHAIPEPHR" FT CDS complement(207464..208255) FT /transl_table=11 FT /gene="Mb1391c" FT /locus_tag="Mb1391c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1391c, -, len: 263 aa. Equivalent to Rv1356c, len: FT 263 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 263 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64828" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94252.1" FT /translation="MLIAGYLTDWRIMTTAQLRPIAPQKLHFSENLSVWVSDAQCRLVV FT SQPALDPTLWNTYLQGALRAYSKHGVECTLDLDAISDGSDTQLFFAAIDIGGDVVGGAR FT VIGPLRSADDSHAVVEWAGNPGLSAVRKMINDRAPFGVVEVKSGWVNSDAQRSDAIAAA FT LARALPLSMSLLGVQFVMGTAAAHALDRWRSSGGVIAARIPAAAYPDERYRTKMIWWDR FT RTLANHAEPKQLSRMLVESRKLLRDVEALSATTAATAGAEQ" FT CDS complement(208728..209651) FT /transl_table=11 FT /gene="Mb1392c" FT /locus_tag="Mb1392c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1392c, -, len: 307 aa. Equivalent to Rv1357c, len: FT 307 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 307 aa overlap). Conserved hypothetical FT protein, similar to members of the YEGE/YHJK/YJCC family FT e.g. Y4LL_RHISN|P55552 hypothetical protein Y4ll from FT Rhizobium sp. (827 aa), FASTA scores: E(): 0, (37.7% FT identity in 257 aa overlap), also similar to FT Rv1354c|MTCY02B10.18c (34.0% identity in 253 aa overlap). FT BELONGS TO THE YEGE/YHDA/YHJK/YJCC FAMILY." FT /db_xref="GOA:P64830" FT /db_xref="InterPro:IPR001633" FT /db_xref="UniProtKB/Swiss-Prot:P64830" FT /protein_id="CAD94253.1" FT /translation="MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWAD FT SDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLP FT GRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVL FT VEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAY FT LPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAA FT RLRAFGCKAAQGWHFAKALPVDFFRE" FT CDS 210047..213526 FT /transl_table=11 FT /gene="Mb1393" FT /locus_tag="Mb1393" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1393, -, len: 1159 aa. Equivalent to Rv1358, len: FT 1159 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 1159 aa overlap). Probable FT transcriptional regulatory protein, some similarity to FT AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces FT coelicolor (993 aa), FASTA scores: opt: 210, E(): 5.5e-06, FT (27.5% identity in 739 aa overlap). Similar also to FT Rv0890C|MTCY31.18c (65.5% identity in 884 aa overlap) and FT to Rv1359|MTCY02B10.23 (43.7% identity in 197 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A, PS00622 FT Bacterial regulatory proteins, luxR family signature. Helix FT turn helix motif present at aa 1116-1137, (Score 1291, FT +3.59 SD)." FT /db_xref="GOA:Q7U073" FT /db_xref="HSSP:1FSE" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:Q7U073" FT /protein_id="CAD94254.1" FT /translation="MFLSAPAFRVEPTRSRHSALRWARHRRFADVPRWQMLRSLQIADQ FT IARTGHMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLNEL FT AADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLAPMR FT PRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPANTWLT FT DVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEVQ FT EVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALG FT LIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRES FT IGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIVADNFAAVSEICRRLDGMPLAI FT ELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWSYALLTDTERILF FT RRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLL FT ETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRA FT AFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARAL FT AEKVILKAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQ FT PYFAEAIELARAINDEWTLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVS FT RQCRLFACLAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIGDSAA FT RTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAIEASEASWDLRNQHNVVTAHH FT ELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELGKARDDAHAA FT VACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGY FT EAATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKI FT VKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST" FT CDS 213608..214360 FT /transl_table=11 FT /gene="Mb1394" FT /locus_tag="Mb1394" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1394, -, len: 250 aa. Equivalent to Rv1359, len: FT 250 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 250 aa overlap). Probable FT transcriptional regulatory protein, similar to FT Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and FT to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap)." FT /db_xref="GOA:Q7U072" FT /db_xref="InterPro:IPR001054" FT /db_xref="UniProtKB/TrEMBL:Q7U072" FT /protein_id="CAD94255.1" FT /translation="MFMALRAPMLERMNGLHTDDAPVNWLERRGGRLTSRRRVTLLHAG FT VEHPMRLWGVQSEAITAAMVLSRKVSAIIAGHCGVRLVDQGVGDGFVAAFAHASDAVAC FT ALELHQAPLSPIVLRIGIHTGEAQLVDERIYAGATMNLAAELRDLAHGGQTVMSGATED FT AVLGRLPMRAWLIGLRPMEGSPERHNFPQSQRIAQLCHPNLRNTFPPLRMRIADASGIP FT YVGRILVNVQVVPHWEGGCAAAGMVLAG" FT CDS 214783..215805 FT /transl_table=11 FT /gene="Mb1395" FT /locus_tag="Mb1395" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1395, -, len: 340 aa. Equivalent to Rv1360, len: FT 340 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 340 aa overlap). Probable oxidoreductase (EC FT 1.-.-.-). Similar to Q49598|G1002714 coenzyme FT F420-dependent n5, n10-methylenetetrahydromethanopterin FT reductase from Methanopyrus kandleri (349 aa), FASTA FT scores: opt: 264, E(): 4.4e-11, (26.3% identity in 323 aa FT overlap)." FT /db_xref="InterPro:IPR011251" FT /db_xref="UniProtKB/Swiss-Prot:P64832" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94256.1" FT /translation="MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEASHDPF FT LPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILGLGTQIRPHIEK FT RFSMPWGHPARRMREFVAALRAIWLAWQDGTKLCFEGEFYTHKIMTPMFTPEPQPYPVP FT RVFIAAVGEAMTEMCGEVADGHLGHPMVSKRYLTEVSVPALLRGLARSGRDRSAFEVSC FT EVMVATGADDAELAAACTATRKQIAFYGSTPAYRKVLEQHGWGDLHPELHRLSKLGEWE FT AMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRVLPIFMAASQECINAALQDFRR FT " FT CDS complement(215878..217068) FT /transl_table=11 FT /gene="PPE19" FT /locus_tag="Mb1396c" FT /standard_name="mtb39b" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1396c, PPE19, len: 396 aa. Similar to Rv1361c, FT len: 396 aa, from Mycobacterium tuberculosis strain H37Rv, FT (92.9% identity in 396 aa overlap). PPE19 (alternate gene FT name: mtb39b). Member of the Mycobacterium tuberculosis PPE FT family of glycine-rich proteins, highly similar to many FT e.g. Rv1196|MTCI364.08|PPE18, FASTA scores: E(): 0, (84.9% FT identity in 397 aa overlap); MTCY274.23c (42.3% identity in FT 416 aa overlap); etc. Contains PS00501 Signal peptidases I FT serine active site. Note that expression of Rv1361c was FT demonstrated in lysates by immunodetection (see first FT citation below). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, the PPE19 gene contains nine FT substitutions compared to Mycobacterium tuberculosis strain FT H37Rv." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7U071" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94257.1" FT /translation="MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASDLFSAASA FT FQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGL FT TVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAAATATAT FT ATLLPFEEAPEMTSAGGLLEQAAAVEEASDTAAANQLMNNVPQALQQLAQPTQGTTPSS FT KLGGLWKTVSPHLSPISNIVSMLNNHVSMTNSGVSMTNTLHSMLKGFAPAAAQAVETAA FT QNGVQAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARA FT LPLTSLTSAAQTAPGHMLGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG" FT CDS complement(217383..218045) FT /transl_table=11 FT /gene="Mb1397c" FT /locus_tag="Mb1397c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb1397c, -, len: 220 aa. Equivalent to Rv1362c, len: FT 220 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 220 aa overlap). Possible membrane FT protein, similar to Mycobacterium tuberculosis hypothetical FT proteins e.g. Rv1362c|MTCY02B10.27c (25.9% identity in 216 FT aa overlap), Rv0177, Rv1973, Rv1972, etc." FT /db_xref="UniProtKB/TrEMBL:Q7U070" FT /protein_id="CAD94258.1" FT /translation="MTDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATEST FT AQKGQRHRDLWRMQVTLKPVPVILILLMLISGGATGWLYLEQYRPDQQTDSGAARAAGA FT AASDGTIALLSYSPDTLDQDFATARSHLAGDFLSYYDQFTQQIVAPAAKQKSLKTTAKV FT VRAAVSELHPDSAVVLVFVDQSTTSKDSPNPSMAASSVMVTLAKVDGNWLITKFTPV" FT CDS complement(218042..218827) FT /transl_table=11 FT /gene="Mb1398c" FT /locus_tag="Mb1398c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb1398c, -, len: 261 aa. Equivalent to Rv1363c, len: FT 261 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 261 aa overlap). Possible membrane FT protein, similar to Mycobacterium tuberculosis hypothetical FT proteins Rv1362c|MTCY02B10.26c (25.9% identity in 216 aa FT overlap ); Rv1972|MTV051.10 and Rv0177 etc." FT /db_xref="UniProtKB/TrEMBL:Q7U069" FT /protein_id="CAD94259.1" FT /translation="MAETTEPPSDAGTSQADAMALAAEAEAAEAEALAAAARARARAAR FT LKREALAMAPAEDENVPEEYADWEDAEDYDDYDDYEAADQEAARSASWRRRLRVRLPRL FT STIAMAAAVVIICGFTGLSGYIVWQHHEATERQQRAAAFAAGAKQGVINMNSLDFNKAK FT EDVARVIDSSTGEFRDDFQQRAADFTKVVEQSKVVTEGTVNATAVESMNEHSAVVLVAA FT TSRVTNSAGAKDEPRAWRLKVTVTEEGGQYKMSKVEFVP" FT CDS complement(219118..221079) FT /transl_table=11 FT /gene="Mb1399c" FT /locus_tag="Mb1399c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1399c, -, len: 653 aa. Equivalent to Rv1364c, len: FT 653 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 653 aa overlap). Conserved hypothetical FT protein, some similarity to RSBU_BACSU|P40399 sigma factor FT sibg regulation protein from Bacillus subtilis (335 aa), FT FASTA scores: opt: 224, E(): 2e-07, (25.8% identity in 244 FT aa overlap)." FT /db_xref="GOA:Q7U068" FT /db_xref="InterPro:IPR010822" FT /db_xref="UniProtKB/TrEMBL:Q7U068" FT /protein_id="CAD94260.1" FT /translation="MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAY FT RGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEER FT YFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQ FT ALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAV FT MSQLRTALRMQISTGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGH FT PPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEA FT STAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAP FT TPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDV FT SKGIVVEAALAGDGNVRASVIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGT FT TATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQ FT IAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLS FT LVQLPVVGADTEDIFAQE" FT CDS complement(221218..221604) FT /transl_table=11 FT /gene="Mb1400c" FT /locus_tag="Mb1400c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1400c, -, len: 128 aa. Equivalent to Rv1365c, len: FT 128 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 128 aa overlap). Conserved hypothetical FT protein, similar to other Mycobacterium tuberculosis FT proteins e.g. Rv2638|MTCY441.08 (148 aa), FASTA scores: FT E(): 0, (53.6% identity in 125 aa overlap); Rv1904, FT Rv3687c. Weak similarity to putative anti-anti-sigma FT factors e.g. AF134889|AF134889_1 Streptomyces coelicolor FT (113 aa), FASTA scores: opt: 137, E(): 0.004, (26.0% FT identity in 100 aa overlap)." FT /db_xref="GOA:Q7U067" FT /db_xref="InterPro:IPR003658" FT /db_xref="UniProtKB/TrEMBL:Q7U067" FT /protein_id="CAD94261.1" FT /translation="MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQ FT DLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHKAERCRRRGVDVRLVSRDRAVAR FT IIHACGYGDVLPVHPTTESALSAT" FT CDS 221825..222646 FT /transl_table=11 FT /gene="Mb1401" FT /locus_tag="Mb1401" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1401, -, len: 273 aa. Equivalent to Rv1366, len: FT 273 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 273 aa overlap). Hypothetical unknown protein." FT /db_xref="GOA:P64834" FT /db_xref="InterPro:IPR007685" FT /db_xref="UniProtKB/Swiss-Prot:P64834" FT /protein_id="CAD94262.1" FT /translation="MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYA FT EVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDIAG FT VRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVEIQI FT RTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHE FT AEWQHCAEIEYPGQRAMALGEASKNKATVLATTKFRLERAINEAESAGGGG" FT CDS complement(222947..224080) FT /transl_table=11 FT /gene="Mb1402c" FT /locus_tag="Mb1402c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1402c, -, len: 377 aa. Equivalent to Rv1367c, len: FT 377 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 377 aa overlap). Conserved hypothetical FT protein. Some similarity to penicillin binding proteins FT e.g. PBPE_BACSU|P32959 penicillin-binding protein 4* (pbp FT 4*) from Bacillus subtilis (451 aa), FASTA scores: E(): FT 6.9e-06, (23.6% identity in 373 aa overlap). Similar to FT AL031107|SC5A7.06 hypothetical protein from Streptomyces FT coelicolor (409 aa), FASTA scores: opt: 675, E(): 0, (40.4% FT identity in 339 aa overlap)." FT /db_xref="HSSP:1CI9" FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q7U066" FT /protein_id="CAD94263.1" FT /translation="MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAAA FT MSLVDEGKLALRDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAY FT GFSVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSRIED FT APLYQVIDERVLGPAGMTDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSF FT CNAGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAP FT FWVGRGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLYLIQHC FT PDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL" FT CDS 224455..225240 FT /transl_table=11 FT /gene="lprF" FT /locus_tag="Mb1403" FT /product="PUTATIVE LIPOPROTEIN LPRF" FT /note="Mb1403, lprF, len: 261 aa. Equivalent to Rv1368, FT len: 261 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 261 aa overlap). Probable lipoprotein FT lprF, similar to Mycobacterium tuberculosis hypothetical FT lipoproteins e.g. Rv1270c|Y08C_MYCTU|Q11049 hypothetical FT 26.4 kd protein cy50.12. (257 aa), FASTA scores: opt: 286, FT E(): 5.3e-11, (26.3% identity in 270 aa overlap), also FT Rv1411c|MTCY21B4.28c, (32.8% identity in 253 aa overlap) FT and Rv2945c. Contains possible N-terminal signal sequence FT and appropriately positioned prokaryotic lipoprotein lipid FT attachment site (PS00013). BELONGS TO THE LPPX/LPRAFG FT FAMILY OF LIPOPROTEINS." FT /db_xref="GOA:P65315" FT /db_xref="InterPro:IPR009830" FT /db_xref="UniProtKB/Swiss-Prot:P65315" FT /protein_id="CAD94264.1" FT /translation="MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTT FT ASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNG FT QAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLG FT AVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNA FT STPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG" FT CDS 225436..226389 FT /pseudo FT /transl_table=11 FT /gene="Mb1404" FT /locus_tag="Mb1404" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb1404, -, len: 317 aa. Similar to 5' end of Rv1371, FT len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, FT (90.9% identity in 166 aa overlap). Probable membrane FT protein. Weak similarity to delta 5 fatty acid desaturases FT e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FT FASTA score: opt: 173, E(): 0.00052, (22.4% identity in 438 FT aa overlap); and Homo sapiens. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1371 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and FT Mb1405, with the latter being the more likely product." FT /db_xref="PSEUDO:CAD94265.1" FT CDS 225911..226906 FT /transl_table=11 FT /gene="Mb1405" FT /locus_tag="Mb1405" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb1405, -, len: 331 aa. Equivalent to 3' end of FT Rv1371, len: 489 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100% identity in 331 aa overlap). Probable membrane FT protein. Weak similarity to delta 5 fatty acid desaturases FT e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FT FASTA score: opt: 173, E(): 0.00052, (22.4% identity in 438 FT aa overlap); and Homo sapiens. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1371 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and FT Mb1405, with the latter being the more likely product." FT /db_xref="GOA:Q7U065" FT /db_xref="InterPro:IPR005804" FT /db_xref="UniProtKB/TrEMBL:Q7U065" FT /protein_id="CAD94266.1" FT /translation="MGYFAVQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQ FT RGLNRVFNNAFDLNYVALSLVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPV FT HTIHKFGHMLSGMAIRIVDVFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVV FT FAIAGDFWPWALQFVATLWVSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVI FT GNRYVDCFLSAGLSSHRVHHVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDR FT LPRLCRKYLLTPSRQAKERHWGFVREHCSPAALKASASYVVAGFVGIGSV" FT CDS 226903..228084 FT /transl_table=11 FT /gene="Mb1406" FT /locus_tag="Mb1406" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1406, -, len: 393 aa. Equivalent to Rv1372, len: FT 393 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 393 aa overlap). Conserved hypothetical FT protein, similar to several chalcone synthases e.g. FT CHS2_GERHY|P48391 chalcone synthase 2 from gerbra hybrid FT (402 aa), FASTA scores: opt: 511, E(): 7e-26, (28.4% FT identity in 380 aa overlap). Also similar to M. FT tuberculosis hypothetical chalcone synthases, Rv1665, FT Rv1660." FT /db_xref="GOA:Q7U064" FT /db_xref="InterPro:IPR011141" FT /db_xref="UniProtKB/TrEMBL:Q7U064" FT /protein_id="CAD94267.1" FT /translation="MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRR FT VVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRD FT RMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSP FT SISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHS FT LFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENL FT PGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDV FT LARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR" FT CDS 228090..228887 FT /transl_table=11 FT /gene="Mb1407" FT /locus_tag="Mb1407" FT /product="GLYCOLIPID SULFOTRANSFERASE [FIRST PART]" FT /EC_number="2.8.2.-" FT /note="Mb1407, -, len: 265 aa. Equivalent to the 5' end of FT Rv1373, len: 326 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100% identity in 154 aa overlap). Glycolipid FT sulfotransferase (EC 2.8.2.-) (see citation below); slight FT similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 FT estrogen sulfotransferase from Cavia porcellus (Guinea pig) FT (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, FT (24.5% identity in 294 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1373 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and FT Mb1408." FT /db_xref="GOA:Q7U063" FT /db_xref="InterPro:IPR000863" FT /db_xref="UniProtKB/TrEMBL:Q7U063" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94268.1" FT /translation="MNSEHPMTDRVVYRSLMADNLRWDALQLRDGDIIISAPSKSGLTW FT TQRLVSLLVFDGPDLPGPLSTVSPWLDQTIRPIEEVVATLDAQQHRRFIKTHTPLDGLV FT LDDRVSYICVGRDPRDAAVSMLYQSANMNEDRMRILHEAVVPFHERIAPPVCGTRSCAQ FT PDRGVPGLDGGAESASPWHRFHTSEGDRHSGQHPAPARHGMGPPSPTQRGLVSLRRLPG FT GLGGRAAPAGKGPRYRRDPRSSPGPGAVRHAGCDALPRVRNRS" FT CDS 228553..229071 FT /pseudo FT /transl_table=11 FT /gene="Mb1408" FT /locus_tag="Mb1408" FT /product="GLYCOLIPID SULFOTRANSFERASE [SECOND PART]" FT /EC_number="2.8.2.-" FT /note="Mb1408, -, len: 172 aa. Equivalent to the 3' end of FT Rv1373, len: 326 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.4% identity in 172 aa overlap). Glycolipid FT sulfotransferase (EC 2.8.2.-) (see citation below); slight FT similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 FT estrogen sulfotransferase from Cavia porcellus (Guinea pig) FT (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, FT (24.5% identity in 294 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv1373 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and FT Mb1408." FT /experiment="experimental evidence, no additional details FT recorded" FT CDS complement(229151..229609) FT /transl_table=11 FT /gene="Mb1409c" FT /locus_tag="Mb1409c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1409c, -, len: 152 aa. Equivalent to Rv1374c, len: FT 152 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 152 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR018271" FT /db_xref="UniProtKB/TrEMBL:Q7U062" FT /protein_id="CAD94270.1" FT /translation="MVTSVADENVASRIASWGTGPAPDPRLDYAHAHLKGRRGRSPARP FT NAPIGARSFAVGRKICRVERFTLLEHGFVGHALHRVPCAGLVALVMSACSLAVCREVGN FT YAQRRVGRFAFFEQTFVRHALTPRCSRTDSKASYTQLNRICKFPPHWV" FT CDS 229911..231230 FT /transl_table=11 FT /gene="Mb1410" FT /locus_tag="Mb1410" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1410, -, len: 439 aa. Equivalent to Rv1375, len: FT 439 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 439 aa overlap). Conserved hypothetical FT protein, similar to hypothetical proteins from several FT organisms e.g. Q52871|U39409 Rhizobium leguminosarum (420 FT aa), FASTA scores: E(): 2e-30, (34.4% identity in 378 aa FT overlap)." FT /db_xref="InterPro:IPR003776" FT /db_xref="UniProtKB/TrEMBL:Q7U061" FT /protein_id="CAD94271.1" FT /translation="MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWPS FT RVLGSADPTTIAHRHGTHRITSPDETWLALQPFLAPAGITRVADVTWLDCLGIPTVQAV FT RPASLTLSVSQGKAASYRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYDPAQ FT LRHRPGSLYHAGVKLDWMVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDTTGLA FT SGNCYDEATLHALYEVMERHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDAGDDVD FT LARIDVWDGYYCFAAELTSATLEVTFGGFGLHHDPNVALSPAITEAAQSRITAISGARE FT DLPSAIYHRFGRVHTYAKARKTSLRLNRARPTPWRVPDVDSLPELVASAATAVANRSGT FT EPLAVVCDFADACVPVVKVLAPGLVLSSASPMRTPLQEAE" FT CDS 231227..232720 FT /transl_table=11 FT /gene="Mb1411" FT /locus_tag="Mb1411" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1411, -, len: 497 aa. Equivalent to Rv1376, len: FT 497 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 497 aa overlap). Conserved hypothetical FT protein, some similarity to hypothetical proteins from FT several organisms e.g. Q52872|U39409 Rhizobium FT leguminosarum (247 aa), FASTA scores: E(): 2.1e-12, (34.7% FT identity in 219 aa overlap)." FT /db_xref="InterPro:IPR012924" FT /db_xref="UniProtKB/TrEMBL:Q7U060" FT /protein_id="CAD94272.1" FT /translation="MTACGRIVVTAGPTISAADIRSVVPDAEVAPPIAFGQALSYDLRS FT GDTLLIVDGLFFQQPSVRHKELLTLMADGVRVVGSSSMGALRAAELHPFGMEGYGWVFE FT SYRDGVLEADDEVGVVHGDADDGYPVFVDALVNMRHTLARAVATGVVCSELAERIIETA FT RATPFTMRTWARLLSEVGAPDQRGLAAQLRSLRVDVKHADALLALRQLGQRPRVEPLRP FT GPPPTVWSRRWRQPWAPPTSVAASADHGESFVDVTDLEVLSFLSVSSVDYWAYRPALQQ FT VAAWYWTLKHPEQSGSVGERAARAVAEVASEGYGRALEFIAYRYALATGIIDETGFPEA FT VAAHWLTTEERHGLGNDPISISARVITRTLFVVRLLPAIDHFLDLLRKDSRLPRWRAMA FT AHALCKRDDLARQKPHLNLGRPDPTQLKRLFGARWGTQVNRIELARRGLMTEDAFYAAA FT TPFAVAAVDDQLPRIEVGTLGPAPLSADVPERHFDFGSV" FT CDS complement(232658..233296) FT /transl_table=11 FT /gene="Mb1412c" FT /locus_tag="Mb1412c" FT /product="PUTATIVE TRANSFERASE" FT /EC_number="2.-.-.-" FT /note="Mb1412c, -, len: 212 aa. Equivalent to Rv1377c, len: FT 212 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 212 aa overlap). Putative transferase (EC FT 2.-.-.-), similar to YQEM_BACSU|P54458 hypothetical 28.3 kd FT protein from Bacillus subtilis (247 aa), FASTA scores: opt: FT 221, E(): 7.6e-08, (30.6% identity in 144 aa overlap); some FT similarity to methyltransferases, also similar to FT Mycobacterium tuberculosis hypothetical proteins Rv0560c, FT Rv3699, and Rv2675c (~ 39.1% identity in 197 aa overlap)." FT /db_xref="GOA:Q7U059" FT /db_xref="HSSP:1UFK" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q7U059" FT /protein_id="CAD94273.1" FT /translation="MPGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGWV FT HGDVLDIGCGLGDNAIYLARNGYQVTGLDISPTALTTAKRRASDAGVDVKFAVGDATKL FT TGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRATRPGATLLLSCFSNAMPPDEEWPRS FT TVSEQTLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRGS" FT CDS complement(233307..234734) FT /transl_table=11 FT /gene="Mb1413c" FT /locus_tag="Mb1413c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1413c, -, len: 475 aa. Equivalent to Rv1378c, len: FT 475 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 475 aa overlap). Conserved hypothetical FT protein, similar to other Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv3074|MTCY22D7.07C (424 aa), FT FASTA scores: E(): 0, (73.0% identity in 429 aa overlap)." FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:Q7U058" FT /protein_id="CAD94274.1" FT /translation="MGNLDLLLHLSGRIVKGCRPLGSVALARCGPAVRWPWWPRPAILE FT HMFDLVSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEADAGVP FT ARRRGRGVASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALEVGRLSEWRATLIVR FT ESACLDVEDRRALDAELCADMSALDGMGDARIAAAARAIAYRLDAQAVVERAARAETER FT TVTIRPAPDTMTWVTALLPVARGVSVYAALKRAADTTFDDRTRGQVMADTLVERVTGQP FT AEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVADTRSRATLRRL FT YRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMPYCDAPIRHRDHAQPHHRGGPTT FT ATNGLGSCERCNYVKEAPGWRVSTDTDETGRHTAEFTTPTGMYYHCTAPPLPGPLEIDV FT SQVEARIGVALTHLHAA" FT CDS 234733..235314 FT /transl_table=11 FT /gene="pyrR" FT /locus_tag="Mb1414" FT /product="PROBABLE PYRIMIDINE OPERON REGULATORY PROTEIN FT PYRR" FT /note="Mb1414, pyrR, len: 193 aa. Equivalent to Rv1379, FT len: 193 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 193 aa overlap). Probable pyrR, FT pyrimidine operon regulatory protein, similar to FT PYRR_BACCL|P41007 pyrimidine operon regulatory protein from FT Bacillus caldolyticus (179 aa), FASTA scores: opt: 544, FT E(): 1.1e-30, (54.2% identity in 179 aa overlap)." FT /db_xref="GOA:P65942" FT /db_xref="HSSP:1A3C" FT /db_xref="InterPro:IPR000836" FT /db_xref="UniProtKB/Swiss-Prot:P65942" FT /protein_id="CAD94275.1" FT /translation="MGAAGDAAIGRESRELMSAADVGRTISRIAHQIIEKTALDDPVGP FT DAPRVVLLGIPTRGVTLANRLAGNITEYSGIHVGHGALDITLYRDDLMIKPPRPLASTS FT IPAGGIDDALVILVDDVLYSGRSVRSALDALRDVGRPRAVQLAVLVDRGHRELPLRADY FT VGKNVPTSRSESVHVRLREHDGRDGVVISR" FT CDS 235311..236270 FT /transl_table=11 FT /gene="pyrB" FT /locus_tag="Mb1415" FT /product="PROBABLE ASPARTATE CARBAMOYLTRANSFERASE PYRB FT (ATCase) (Aspartate transcarbamylase)" FT /EC_number="2.1.3.2" FT /note="Mb1415, pyrB, len: 319 aa. Equivalent to Rv1380, FT len: 319 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 319 aa overlap). Probable pyrB, aspartate FT carbamoyltransferase (EC 2.1.3.2), similar to many e.g. FT PYRB_BACCL|P41008 aspartate carbamoyltransferase from FT Bacillus caldolyticus (308 aa), FASTA scores, opt: 639, FT E(): 7.3e-36, (39.5% identity in 311 aa overlap). Contains FT PS00097 Aspartate and ornithine carbamoyltransferases FT signature. BELONGS TO THE ATCASES/OTCASES FAMILY." FT /db_xref="GOA:P65614" FT /db_xref="HSSP:1GQ3" FT /db_xref="InterPro:IPR006131" FT /db_xref="UniProtKB/Swiss-Prot:P65614" FT /protein_id="CAD94276.1" FT /translation="MTPRHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRGR FT TVVTMFYENSTRTRVSFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGADAL FT IIRHPASGAAHLLAQWTGAHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRI FT VIVGDILHSRVARSNVMLLDTLGAEVVLVAPPTLLPVGVTGWPATVSHDFDAELPAADA FT VLMLRVQAERMNGGFFPSVREYSVRYGLTERRQAMLPGHAVVLHPGPMVRGMEITSSVA FT DSSQSAVLQQVSNGVQVRMAVLFHVLVGAQDAGKEGAA" FT CDS 236267..237559 FT /transl_table=11 FT /gene="pyrC" FT /locus_tag="Mb1416" FT /product="PROBABLE DIHYDROOROTASE PYRC (DHOase)" FT /EC_number="3.5.2.3" FT /note="Mb1416, pyrC, len: 430 aa. Equivalent to Rv1381, FT len: 430 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 430 aa overlap). Probable pyrC, FT dihydroorotase (EC 3.5.2.3), similar to many e.g. FT PYRC_BACCL|P46538 (40.5% identity in 395 aa overlap). FT Contains PS00483 Dihydroorotase signature 2. BELONGS TO THE FT DHOASE FAMILY. SUBFAMILY 2." FT /db_xref="GOA:Q7U057" FT /db_xref="InterPro:IPR002195" FT /db_xref="UniProtKB/Swiss-Prot:Q7U057" FT /protein_id="CAD94277.1" FT /translation="MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDAT FT GHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDH FT VWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRR FT ALEYATGLGVLIAQHAEEPRLTVGAFAHEGPMAARLGLAGWPRAAEESIVARDALLARD FT AGARVHICHASAAGTVEILKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLR FT EASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVA FT PGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSA FT NTPFESMSLPATVTATLLRGKVTARDGKIRA" FT CDS 237556..238053 FT /transl_table=11 FT /gene="Mb1417" FT /locus_tag="Mb1417" FT /product="PROBABLE EXPORT OR MEMBRANE PROTEIN" FT /note="Mb1417, -, len: 165 aa. Equivalent to Rv1382, len: FT 165 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 165 aa overlap). Possible exported or membrane FT protein, hydrophobic domain at N-terminus." FT /db_xref="UniProtKB/TrEMBL:Q7U056" FT /protein_id="CAD94278.1" FT /translation="MNSGTLAGSLIFAAVLVMLIAVLARLMMRGWRRRSERQAELLGDL FT PDVPEHVSSATVTTRGLYVGATLSPAWNERVTVGDLGYRSKAVLTRYPSGIMVERARAQ FT PIWIPTESIAAIRMERGVAGKVVAGIGILAIRWRLPSGTEIDVGFRADNRDEYQEWLEE FT PV" FT CDS 238050..239180 FT /transl_table=11 FT /gene="carA" FT /locus_tag="Mb1418" FT /product="PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN FT CARA (Carbamoyl-phosphate synthetase glutamine chain)" FT /EC_number="6.3.5.5" FT /note="Mb1418, carA, len: 376 aa. Equivalent to Rv1383, FT len: 376 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 376 aa overlap). Probable carA, FT Carbamoyl-phosphate synthase small chain (EC 6.3.5.5), FT similar to many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate FT synthase small chain from Escherichia coli (382 aa), FASTA FT scores: opt: 796, E(): 0, (45.5% identity in 382 aa FT overlap). Contains PS00442 Glutamine amidotransferases FT class-I active site. THE GATASE DOMAIN BELONGS TO TYPE-1 FT GLUTAMINE AMIDOTRANSFERASES. SUBUNIT: COMPOSED OF TWO FT CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE FT HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS USED BY THE FT LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL FT PHOSPHATE." FT /db_xref="GOA:Q7U055" FT /db_xref="HSSP:1CE8" FT /db_xref="InterPro:IPR000991" FT /db_xref="UniProtKB/Swiss-Prot:Q7U055" FT /protein_id="CAD94279.1" FT /translation="MSKAVLVLEDGRVFTGRPFGATGQALGEAVFSTGMSGYQETLTDP FT SYHRQIVVATAPQIGNTGWNGEDSESRGERIWVAGYAVRDPSPRASNWRATGTLEDELI FT RQRIVGIAGIDTRGVVRHLRSRGSMKAGVFSDGALAEPADLIARVRAQQSMLGADLAGE FT VSTAEPYVVEPDGPPGVSRFTVAALDLGIKTNTPRNFARRGIRCHVLPASTTFEQIAEL FT NPHGVFLSNGPGDPATADHVVALTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGH FT RGINIPVVDHATGRVAVTAQNHGFALQGEAGQSFATPFGPAVVSHTCANDGVVEGVKLV FT DGRAFSVQYHPEAAAGPHDAEYLFDQFVELMAGEGR" FT CDS 239180..242527 FT /transl_table=11 FT /gene="carB" FT /locus_tag="Mb1419" FT /product="PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN FT CARB (Carbamoyl-phosphate synthetase ammonia chain)" FT /EC_number="6.3.5.5" FT /note="Mb1419, carB, len: 1115 aa. Equivalent to Rv1384, FT len: 1115 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1115 aa overlap). Probable carB, FT Carbamoyl-phosphate synthase large chain (EC 6.3.5.5), FT similar to many e.g. CARB_ECOLI|P00968 E. coli (1072 aa), FT FASTA scores: E(): 0, (52.3% identity in 1118 aa overlap). FT Contains two PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2 and PS00866 Carbamoyl-phosphatesynthase FT subdomain signature 1. SUBUNIT: COMPOSED OF TWO CHAINS; THE FT SMALL (OR GLUTAMINE) CHAIN PROMOTES THE HYDROLYSIS OF FT GLUTAMINE TO AMMONIA, WHICH IS USED BY THE LARGE (OR FT AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL PHOSPHATE." FT /db_xref="GOA:Q7U054" FT /db_xref="HSSP:1CS0" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/Swiss-Prot:Q7U054" FT /protein_id="CAD94280.1" FT /translation="MPRRTDLHHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLQVS FT LVNSNPATIMTDPEFADHTYVEPITPAFVERVIAQQAERGNKIDALLATLGGQTALNTA FT VALYESGVLEKYGVELIGADFDAIQRGEDRQRFKDIVAKAGGESARSRVCFTMAEVRET FT VAELGLPVVVRPSFTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGWKEFE FT LELMRDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAILREVG FT VDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEI FT VNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFVEAL FT GKVMRSLETTRAGFWTAPDPDGGIEEALTRLRTPAEGRLYDIELALRLGATVERVAEAS FT GVDPWFIAQINELVNLRNELVAAPVLNAELLRRAKHSGLSDHQIASLRPELAGEAGVRS FT LRVRLGIHPVYKTVDTCAAEFEAQTPYHYSSYELDPAAETEVAPQTERPKVLILGSGPN FT RIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEV FT YHAEMESGSGGPGVAGVIVQLGGQTPLGLAHRLADAGVPIVGTPPEAIDLAEDRGAFGD FT LLSAAGLPAPKYGTATTFAQARRIAEEIGYPVLVRPSYVLGGRGMEIVYDEETLQGYIT FT RATQLSPEHPVLVDRFLEDAVEIDVDALCDGAEVYIGGIMEHIEEAGIHSGDSACALPP FT VTLGRSDIEKVRKATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT FT AVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAARNAPIAVKEAVLPFHRFRRADGA FT AIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQGTVFVSVANRDKRSLVFP FT VKRLADLGFRVLATEGTAEMLRRNGIPCDDVRKHFEPAQPGRPTMSAVDAIRAGEVNMV FT INTPYGNSGPRIDGYEIRSAAVAGNIPCITTVQGASAAVQGIEAGIRGDIGVRSLQELH FT RVIGGVER" FT CDS 242524..243348 FT /transl_table=11 FT /gene="pyrF" FT /locus_tag="Mb1420" FT /product="PROBABLE OROTIDINE 5'-PHOSPHATE DECARBOXYLASE FT PYRF (OMP decarboxylase) (OMPdecase)" FT /EC_number="4.1.1.23" FT /note="Mb1420, pyrF, len: 274 aa. Equivalent to Rv1385, FT len: 274 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 274 aa overlap). Probable pyrF, orotidine FT 5'-phosphate decarboxylase (EC 4.1.1.23), identical to FT DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains FT PS00156 Orotidine 5'-phosphate decarboxylase active site. FT BELONGS TO THE OMP DECARBOXYLASE FAMILY." FT /db_xref="GOA:P0A5M7" FT /db_xref="InterPro:IPR001754" FT /db_xref="UniProtKB/Swiss-Prot:P0A5M7" FT /protein_id="CAD94281.1" FT /translation="MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFC FT DICVRAFADFAVVKPQVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMS FT AYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNA FT AADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQG FT GRPEALGGLGGAASSQLLPAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV" FT CDS 243543..243851 FT /transl_table=11 FT /gene="PE15" FT /locus_tag="Mb1421" FT /product="PE FAMILY PROTEIN" FT /note="Mb1421, PE15, len: 102 aa. Equivalent to Rv1386, FT len: 102 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 102 aa overlap). Member of Mycobacterium FT tuberculosis PE family (see first citation below), similar FT to many e.g. G913039 ORF 3' OF PGRS TANDEM REPEAT FT (polymorphic GC-rich sequence) (100 aa), FASTA scores: opt: FT 149, E(): 0.0013, (31.5% identity in 92 aa overlap); also FT similar to Q49943|U1756A (99 aa) (34.7% identity in 95 aa FT overlap) and G466937|U1620K (100 aa) (36.2% identity in 69 FT aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/Swiss-Prot:P0A683" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94282.1" FT /translation="MTLRVVPESLAGASAAIEAVTARLAAAHAAAAPFIAAVIPPGSDS FT VSVCNAVEFSVHGSQHVAMAAQGVEELGRSGVGVAESGASYAARDALAAASYLSGGL" FT CDS 243848..245467 FT /transl_table=11 FT /gene="PPE20" FT /locus_tag="Mb1422" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1422, PPE20, len: 539 aa. Equivalent to Rv1387, FT len: 539 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 539 aa overlap). Member of Mycobacterium FT tuberculosis PPE family of proteins, similar to many e.g. FT Y05F_MYCTU|Q10892 hypothetical 46.9 kd protein cy251.15 FT (463 aa), FASTA scores: E(): 4.2e-26, (37.7% identity in FT 531 aa overlap); similar also to MTCY274.23c (37.5% FT identity in 168 aa overlap). Contains PS00343 Gram-positive FT cocci surface proteins 'anchoring' hexapeptide." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7U053" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94283.1" FT /translation="MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAAS FT EVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMAAQQHAVIEAYTAAVE FT LMPTQVELAANQIKLAVLVATNFFGINTIPIAINEAEYVEMWVRAATTMATYSTVSRSA FT LSAMPHTSPPPLILKSDELLPDTGEDSDEDGHNHGGHSHGGHARMIDNFFAEILRGVSA FT GRIVWDPVNGTLNGLDYDDYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFLL FT YVVVVDLPTHIAQIATWLGQYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPSAAIPAV FT VPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAAGPTPPATGFGGFPP FT YLVGGGGPGIGFGSGQSAHAKAAASDSAAAESAAQASARAQARAARRGRSAAKARGHRD FT EFVTMDMGFDAAAPAPEHQPGARASDCGAGPIGFAGTVRKEAVVKAAGLTTLAGDDFGG FT GPTMPMMPGTWTHDQGVFDEHR" FT CDS 245773..246345 FT /transl_table=11 FT /gene="mihF" FT /locus_tag="Mb1423" FT /product="PUTATIVE INTEGRATION HOST FACTOR MIHF" FT /note="Mb1423, mihF, len: 190 aa. Equivalent to Rv1388, FT len: 190 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 190 aa overlap). Putative mihF, FT integration host factor. Almost identical to, but longer FT than, P96802|U75344 Mycobacterium smegmatis integration FT host factor (mIHF) for mycobacteriophage L5 (105 aa), FASTA FT scores: E(): 0, (96.1% identity in 102 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U052" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94284.1" FT /translation="MLGNTIHVPCQPCRHGHGAPSRGLRGRPADRWPVARATPTLHVCP FT QNQGVGLDFVRKPEYGRLRWPAYPAGTNNDRLISMRDGGIVALPQLTDEQRAAALEKAA FT AARRARAELKDRLKRGGTNLTQVLKDAESDEVLGKMKVSALLEALPKVGKVKAQEIMTE FT LEIAPTRRLRGLGDRQRKALLEKFGSA" FT CDS 246480..247106 FT /transl_table=11 FT /gene="gmk" FT /locus_tag="Mb1424" FT /product="PROBABLE GUANYLATE KINASE GMK" FT /EC_number="2.7.4.8" FT /note="Mb1424, gmk, len: 208 aa. Equivalent to Rv1389, len: FT 208 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 208 aa overlap). Probable gmk, guanylate kinase FT (EC 2.7.4.8), similar to e.g. KGUA_ECOLI|P24234 guanylate FT kinase from Escherichia coli (207 aa), FASTA scores: opt: FT 424, E(): 6.6e-20, (35.9% identity in 184 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop), FT PS00856 Guanylate kinase signature. BELONGS TO THE FT GUANYLATE KINASE FAMILY." FT /db_xref="GOA:P0A5I5" FT /db_xref="InterPro:IPR008145" FT /db_xref="UniProtKB/Swiss-Prot:P0A5I5" FT /protein_id="CAD94285.1" FT /translation="MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERI FT PNLHFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQ FT PVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVI FT QRRLDTARIELAAQGDFDKVVVNRRLESACAELVSLLVGTAPGSP" FT CDS 247172..247504 FT /transl_table=11 FT /gene="rpoZ" FT /locus_tag="Mb1425" FT /product="PROBABLE DNA-DIRECTED RNA POLYMERASE (OMEGA FT CHAIN) RPOZ (TRANSCRIPTASE OMEGA CHAIN) (RNA POLYMERASE FT OMEGA SUBUNIT)" FT /EC_number="2.7.7.6" FT /note="Mb1425, rpoZ, len: 110 aa. Equivalent to Rv1390, FT len: 110 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 110 aa overlap). Probable rpoZ, FT DNA-directed RNA polymerase omega chain (EC 2.7.7.6). FT BELONGS TO THE RNA POLYMERASE OMEGA CHAIN FAMILY." FT /db_xref="GOA:P66722" FT /db_xref="InterPro:IPR006110" FT /db_xref="UniProtKB/Swiss-Prot:P66722" FT /protein_id="CAD94286.1" FT /translation="MSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELLD FT RVSSKYALVIYAAKRARQINDYYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLL FT EHTEGE" FT CDS 247520..248776 FT /transl_table=11 FT /gene="dfp" FT /locus_tag="Mb1426" FT /product="PROBABLE DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN FT HOMOLOG DFP" FT /note="Mb1426, dfp, len: 418 aa. Equivalent to Rv1391, len: FT 418 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 418 aa overlap). Probable dfp, DNA/pantothenate FT metabolism flavoprotein homolog, similar to many e.g. FT DFP_ECOLI|P24285 Escherichia coli (430 aa), FASTA scores: FT opt: 763, E(): 0, (40.2% identity in 408 aa overlap)." FT /db_xref="GOA:P67734" FT /db_xref="HSSP:1MVN" FT /db_xref="InterPro:IPR003382" FT /db_xref="UniProtKB/Swiss-Prot:P67734" FT /protein_id="CAD94287.1" FT /translation="MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTES FT ALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRA FT DDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSG FT AGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQG FT YAVARVAAQRGADVTLIAGHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAA FT AVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAET FT GDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKT FT LMASRIVDAIVTFLAGCSS" FT CDS 248904..250115 FT /transl_table=11 FT /gene="metK" FT /locus_tag="Mb1427" FT /product="PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE METK FT (MAT) (AdoMet synthetase) (Methionine adenosyltransferase)" FT /EC_number="2.5.1.6" FT /note="Mb1427, metK, len: 403 aa. Equivalent to Rv1392, FT len: 403 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 403 aa overlap). Probable metK, FT S-adenosylmethionine synthetase (EC 2.5.1.6), similar to FT many e.g. METK_STAAU|P50307 Staphylococcus aureus (397 aa), FT FASTA scores: opt: 1484, E(): 0, (58.0% identity in 400 aa FT overlap). Contains PS00376 S-adenosylmethionine synthetase FT signature 1, PS00377 S-adenosylmethionine synthetase FT signature 2. BELONGS TO THE ADOMET SYNTHETASE FAMILY." FT /db_xref="GOA:Q7U051" FT /db_xref="InterPro:IPR002133" FT /db_xref="UniProtKB/Swiss-Prot:Q7U051" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94288.1" FT /translation="MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVE FT TLVTTGQVHVVGEVATSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQ FT SPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELMPLPIALAHRLSRR FT LTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVVISTQHAADIDLEKTLDPDIREK FT VLNTVLDDLAHETLDASTVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGG FT AFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTET FT EDPVKIEKAIGEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDL FT KRAI" FT CDS complement(250188..251666) FT /transl_table=11 FT /gene="Mb1428c" FT /locus_tag="Mb1428c" FT /product="PROBABLE MONOXYGENASE" FT /EC_number="1.14.13.-" FT /note="Mb1428c, -, len: 492 aa. Equivalent to Rv1393c, len: FT 492 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 492 aa overlap). Probable monooxygenase (EC FT 1.14.13.-), similar to others e.g. CYMO_ACISP|P12015 FT cyclohexanone monooxygenase (EC 1.14.13.22) from FT Acinetobacter sp. (542 aa), FASTA scores: E(): 0, (33.0% FT identity in 473 aa overlap); also to FT Rv3083|MTCY31.20|E241788 hypothetical 55.0 kDa protein from FT Mycobacterium tuberculosis (495 aa) (36.3% identity in 490 FT aa overlap); and Rv0565c, Rv3854c, Rv3049c, Rv0892." FT /db_xref="GOA:Q7U050" FT /db_xref="InterPro:IPR002937" FT /db_xref="UniProtKB/TrEMBL:Q7U050" FT /protein_id="CAD94289.1" FT /translation="MMPDYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTWH FT WNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYGIRSRIRLNTKV FT LAAEFDDEHSLWRVQTDPGGEITARFLISACGILTVPKLPDIDGVDSFEGVTMHTARWD FT HTQDLTGKRVGIIGTGASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFDVPLPTAVRWAM FT RIPGGKAVHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHDPVVREQLT FT PRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHEIDVLVLATGF FT KVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPGYPNFFTVFGPYGYVGSSYF FT ALIETQAHHIIRCLKRARRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSY FT YFDKNGDVPLRPTTTVEAYWRSRRFDLGDYRISS" FT CDS complement(251663..253048) FT /transl_table=11 FT /gene="cyp132" FT /locus_tag="Mb1429c" FT /product="PROBABLE CYTOCHROME P450 132 CYP132" FT /EC_number="1.14.-.-" FT /note="Mb1429c, cyp132, len: 461 aa. Equivalent to Rv1394c, FT len: 461 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 461 aa overlap). Probable cyp132, FT cytochrome P450 132 (EC 1.14.-.- ). Some similarity to FT others e.g. CP4B_HUMAN|P13584 human cytochrome p450 (511 FT aa), FASTA scores: opt: 486, E(): 7.4e-21, (28.6% identity FT in 423 aa overlap); etc. Contains PS00086 Cytochrome P450 FT cysteine heme-iron ligand signature. MAY BELONG TO THE FT CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P59954" FT /db_xref="InterPro:IPR002401" FT /db_xref="UniProtKB/Swiss-Prot:P59954" FT /protein_id="CAD94290.1" FT /translation="MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGSD FT ITRFRCAGRRFVSISHPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWARH FT RGALNSTFARRHLRGLVGLMIDPIADVTAALVPGAQFDMHQSMVETTLRVVANALFSQD FT FGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLREMQEI FT TLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGHETTAN FT AMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSVWI FT IAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPTDRPRCAY FT LPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRPKHGVHVIG FT RRR" FT CDS 253126..254160 FT /transl_table=11 FT /gene="Mb1430" FT /locus_tag="Mb1430" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1430, -, len: 344 aa. Equivalent to Rv1395, len: FT 344 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 344 aa overlap). Probable transcriptional FT regulatory protein, similar to many e.g. URER_PROMI|Q02458 FT urease operon transcriptional activator from Proteus FT mirabilis (293 aa), FASTA scores: E():1.5e-08, (41.7% FT identity in 84 aa overlap); YHIX_ECOLI|P37639 hypothetical FT transcriptional regulatory protein from Escherichia coli FT (274 aa), FASTA scores: opt: 238, E(): 3.5e-09, (27.3% FT identity in 249 aa overlap); and G296916|X68281 POSSIBLE FT VIRULENCE-REGULATING protein from Mycobacterium FT tuberculosis (339 aa), FASTA scores: opt: 228, E(): FT 1.9e-08, (27.0% identity in 278 aa overlap). Helix turn FT helix motif present, aa 261-282 (+4.68 SD). BELONGS TO THE FT ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. 3' part FT corrected since first submission (-14 aa)." FT /db_xref="GOA:P68912" FT /db_xref="InterPro:IPR018060" FT /db_xref="UniProtKB/Swiss-Prot:P68912" FT /protein_id="CAD94291.1" FT /translation="MGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADL FT DDPDAVVGALDEITAVRRLLARLPDDAGIGIDVGSRFALTHFGLFGFAVMSCGTLRELL FT TIAMRYFALTTMHVDITLFETADDCLVELDASHLPADVRGFFIERDIAGIIATTTSFAL FT PLAAKYADQVSAELAVDAELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQADRH FT TLEMCIAQCDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRLA FT EEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEY FT SRRG" FT CDS complement(254206..255564) FT /transl_table=11 FT /gene="PE_PGRS25" FT /locus_tag="Mb1431c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1431c, PE_PGRS25, len: 452 aa. Similar to Rv1396c, FT len: 576 aa, from Mycobacterium tuberculosis strain H37Rv, FT (78.1% identity in 576 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, strong similarity to many e.g. glycine FT rich protein MTCY130.10C|E245019 (603 aa), FASTA scores: FT opt: 1945, E(): 0, (57.5% identity in 619 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A, similar to FT other PGRS-type sequences. REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium bovis, a 372 bp deletion leads to a FT shorter product with a different COOH part compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv (452 aa FT versus 576 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U049" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94292.1" FT /translation="MSFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAAGAD FT EVSAAVAALFSGHAQTYQALSTQAAAFHQQIVQTLTSTAGAYASAEAANVEQQLLGAIN FT APTMALLGRPLIGHGADGAPGTGQAGGAGGILYGNGGNGGSGATGQAGGAGGAAGLIGH FT GGAGGLGGTGASGGAGGAGGWLWGNGGAGGNGGVGVAGDPGGVGGAGGAGGAAGLWGSG FT GSGGTGGQGGVGGGKSGDGGTGGIGGAGGGGGWLHGDGGAGGHGGQGGTGVSSGGNGGA FT GGTGGDGRGLSGSGGAGGHGGQTGVGGKVGENNFGGAGGAGGTGGLIGNGGAGGTGGKG FT GDGFGVFGKGGAGGTGGRGGAAGLIGDAGTGGTGGKGGTAGEDGTGGNGGTGGNGGAAV FT LIGNGGGGGAGGNGGAGNDGTPGNGGGGGVGGTGGTLFGQPGQPGPPGQPGPA" FT CDS complement(255819..256220) FT /transl_table=11 FT /gene="Mb1432c" FT /locus_tag="Mb1432c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1432c, -, len: 133 aa. Equivalent to Rv1397c, len: FT 133 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 133 aa overlap). Conserved hypothetical FT protein, similar to Mycobacterium tuberculosis protein FT MTCY159.08C|Rv2548 (125 aa), FASTA scores: E(): 2.3e-14, FT (42.4% identity in 125 aa overlap)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:Q7U048" FT /protein_id="CAD94293.1" FT /translation="MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGG FT MRTAERREVWRLLASFRVQPATEVIARRAGDMMRRYRRSHNRIGLGDYLIAATADVQGL FT QLATLNVWHFPMFEQLKPPFAVPGHRPRA" FT CDS complement(256217..256474) FT /transl_table=11 FT /gene="Mb1433c" FT /locus_tag="Mb1433c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1433c, -, len: 85 aa. Equivalent to Rv1398c, len: FT 85 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 85 aa overlap). Conserved hypothetical protein, FT similar to Mycobacterium tuberculosis proteins FT Rv2547|MTCY159.09C (85 aa), FASTA scores: E(): 0.0035, FT (37.1% identity in 62 aa overlap); Rv0581, Rv2871, Rv1241, FT etc." FT /db_xref="GOA:P64836" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/Swiss-Prot:P64836" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94294.1" FT /translation="MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDD FT LASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQVWRATS" FT CDS complement(256557..257516) FT /transl_table=11 FT /gene="lipH" FT /locus_tag="Mb1434c" FT /product="PROBABLE LIPASE LIPH" FT /EC_number="3.1.-.-" FT /note="Mb1434c, lipH, len: 319 aa. Equivalent to Rv1399c, FT len: 319 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 319 aa overlap). Possible LipH, lipase FT (EC 3.1.-.-), most similar to G695278 lipase like enzyme FT from Ralstonia eutropha (364 aa), FASTA scores: opt: 648, FT E(): 4.4e-34, (37.3% identity in 327 aa ov erlap), similar FT to Mycobacterium tuberculosis hypothetical lipases e.g. FT Rv2284, Rv2485c, Rv1426c, etc." FT /db_xref="GOA:Q7U047" FT /db_xref="HSSP:1JJI" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:Q7U047" FT /protein_id="CAD94295.1" FT /translation="MTEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTP FT PELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDNLPVVVYYHGGGWSLGGLDTHDPVA FT RAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAGDSA FT GGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAW FT YVPGLDISDHTMLPTTLAPGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVE FT LSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA" FT CDS complement(257541..258503) FT /transl_table=11 FT /gene="lipI" FT /locus_tag="Mb1435c" FT /product="PROBABLE LIPASE LIPH" FT /EC_number="3.1.-.-" FT /note="Mb1435c, lipI, len: 320 aa. Equivalent to Rv1400c, FT len: 320 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 320 aa overlap). Possible lipI, lipase FT (EC 3.1.-.-), most similar to G695278 lipase like enzyme FT (364 aa), FASTA sscores: opt: 611, E(): 3.5e-30, (36.6% FT identity in 352 aa overlap); similar to Mycobacterium FT tuberculosis hypothetical lipases e.g. Rv1399c|MTCY21B4.16c FT (58.1% identical in 315 aa overlap); Rv1426c, Rv2284, etc." FT /db_xref="GOA:Q7U046" FT /db_xref="HSSP:1JJI" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:Q7U046" FT /protein_id="CAD94296.1" FT /translation="MPSLDNTADEKPAIDPILLKVLDAVPFRLSIDDGIEAVRQRLRDL FT PRQPVHPELRVVDLAIDGPAGPIGTRIYWPPTCPDQAEAPVVLYFHGGGFVMGDLDTHD FT GTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAATRWVAEHGRQVGADLGRIAVAG FT DSAGGTIAAVIAQRARDMGGPPIVFQLLWYPSTLWDQSLPSLAENADAPILDVKAIAAF FT SRWYAGEIDLHNPPAPMAPGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPV FT EVHNAQTLVHGYVGYAGVVPAATEATNRGLVALRVVLHG" FT CDS 258637..259239 FT /transl_table=11 FT /gene="Mb1436" FT /locus_tag="Mb1436" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb1436, -, len: 200 aa. Equivalent to Rv1401, len: FT 200 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 200 aa overlap). Possible membrane protein." FT /db_xref="GOA:P64838" FT /db_xref="InterPro:IPR012506" FT /db_xref="UniProtKB/Swiss-Prot:P64838" FT /protein_id="CAD94297.1" FT /translation="MLQPAFKASMAVLLAAAAVAHPIGRERRWLVPALLLSATGDWLLA FT IPWWTWAFVFGLGAFLLAHLCFIGALLPLARQAAPSRGRVAAVVAMCVASAGLLVWFWP FT HLGKDNLTIPVTVYIVALSAMVCTALLARLPTIWTAVGAVCFAASDSMIGIGRFILGNE FT ALAVPIWWSYAAAEILITAGFFFGREVPDNAAAPTDS" FT CDS 259320..261287 FT /transl_table=11 FT /gene="priA" FT /locus_tag="Mb1437" FT /product="PUTATIVE PRIMOSOMAL PROTEIN N' PRIA (Replication FT factor Y)" FT /note="Mb1437, priA, len: 655 aa. Equivalent to Rv1402, FT len: 655 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 655 aa overlap). Putative priA, FT primosomal protein N'. Similar to e.g. PRIA_ECOLI|P17888 FT primosomal protein N' (replication factor Y) (732 aa), FT FASTA scores, opt: 386, E(): 1.3e-16, (27.6% identity in FT 711 aa overlap). Compared to other bacterial priA, it has a FT very divergent helicase domain. BELONGS TO THE HELICASE FT FAMILY. PRIA SUBFAMILY." FT /db_xref="GOA:P0A5A6" FT /db_xref="UniProtKB/Swiss-Prot:P0A5A6" FT /protein_id="CAD94298.1" FT /translation="MLSVPHLDRDFDYLVPAEHSDDAQPGVRVRVRFHGRLVDGFVLER FT RSDSDHHGKLGWLDRVVSPEPVLTTEIRRLVDAVAARYAGTRQDVLRLAVPARHARVER FT EITTAPGRPVVAPVDPSGWAAYGRGRQFLAALADSRAARAVWQALPGELWADRFAEAAA FT QTVRAGRTVLAIVPDQRDLDTLWQAATALVDEHSVVALSAGLGPEARYRRWLAALRGSA FT RLVIGTRSAVFAPLSELGLVMVWADADDSLAEPRAPYPHAREVAMLRAHQARCAALIGG FT YARTAEAHALVRSGWAHDVVAPRPEVRARSPRVVALDDSGYDDARDPAARTARLPSIAL FT RAARSALQSGAPVLVQVPRRGYIPSLACGRCRAIARCRSCTGPLSLQGAGSPGAVCRWC FT GRVDPTLRCVRCGSDVVRAVVVGARRTAEELGRAFPGTAVITSAGDTLVPQLDAGPALV FT VATPGAEPRAPGGYGAALLLDSWALLGRQDLRAAEDALWRWMTAAALVRPRGAGGVVTV FT VAESSIPTVQSLIRWDPVGHAEAELAARTEVGLPPSVHIAALDGPAGTVTALLEAARLP FT DPDRLQADLLGPVDLPPGVRRPAGIPADAPVIRMLLRVCREQGLELAASLRRGIGVLSA FT RQTRQTRSLVRVQIDPLHIG" FT CDS complement(261305..262129) FT /transl_table=11 FT /gene="Mb1438c" FT /locus_tag="Mb1438c" FT /product="PUTATIVE METHYLTRANSFERASE" FT /EC_number="2.1.1.-" FT /note="Mb1438c, -, len: 274 aa. Equivalent to Rv1403c, len: FT 274 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 274 aa overlap). Putative methyltransferase (EC FT 2.1.1.-), similar to PMTA_RHOSH|Q05197 FT phosphatidylethanolamine m-methyltransferase (203 aa), FT FASTA scores: opt: 217, E(): 1.1e-07, (37.1% identity in FT 105 aa overlap); similar to Rv1405c|MTCY21B4.22c (59.3% FT identity in 273 aa overlap) and to Rv1523, Rv2952, etc." FT /db_xref="GOA:P64840" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P64840" FT /protein_id="CAD94299.1" FT /translation="MTVYTPTSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVSTS FT GIRRGDRVLDVAAGSGNVSIPAAMAGAHVTASDLTPELLRRAQARAAAAGLELGWREAN FT AEALPFSAGEFDAVLSTIGVMFAPRHQRTADELARVCRRGGKISTLNWTPEGFYGKLLS FT TIRPYRPTLPAGAPHEVWWGSEDYVSGLFRDHVSDIRTRRGSLTVDRFGCPDECRDYFK FT NFYGPAINAYRSIADSPECVATLDAEITELCREYLCDGVMQWEYLIFTARKC" FT CDS 262298..262780 FT /transl_table=11 FT /gene="Mb1439" FT /locus_tag="Mb1439" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb1439, -, len: 160 aa. Equivalent to Rv1404, len: FT 160 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 160 aa overlap). Probable transcriptional FT regulatory protein, some similarity to MARR_ECOLI|P27245 FT multiple antibiotic resistance protein from Escherichia FT coli (125 aa), FASTA scores: opt: 136, E(): 0.004, (35.1% FT identity in 74 aa overlap)." FT /db_xref="GOA:Q7U045" FT /db_xref="InterPro:IPR000835" FT /db_xref="UniProtKB/TrEMBL:Q7U045" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94300.1" FT /translation="MMPTEYPATAEESVDVITDALLTASRLLVAISAHSIAQVDENITI FT PQFRTLVILSNHGPINLATLATLLGVQPSATGRMVDRLVGAELIDRLPHPTSRRELLAA FT LTKRGRDVVRQVTEHRRTEIARIVEQMAPAERHGLVRALTAFTEAGGEPDARYEIE" FT CDS complement(262852..263676) FT /transl_table=11 FT /gene="Mb1440c" FT /locus_tag="Mb1440c" FT /product="PUTATIVE METHYLTRANSFERASE" FT /EC_number="2.1.1.-" FT /note="Mb1440c, -, len: 274 aa. Equivalent to Rv1405c, len: FT 274 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 274 aa overlap). Putative methyltransferase (EC FT 2.1.1.-), most similar to PMTA_RHOSH|Q05197 FT phosphatidylethanolamine m-methyltransferase (203 aa), FT FASTA scores: opt: 219, E(): 2.6e-07, (29.9% identity in FT 144 aa overlap); similar to Rv1403c|MTCY21B4.20c (59.3% FT identity in 273 aa overlap), Rv1523, Rv2952, etc." FT /db_xref="GOA:P64842" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P64842" FT /protein_id="CAD94301.1" FT /translation="MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAAA FT GIGPGVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQQGLTLQYQEAN FT AQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISWTCEGFFGRMLA FT TIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFDTAQAVHDYFK FT NNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDGVMEWEYLLLTAEKR" FT CDS 263873..264811 FT /transl_table=11 FT /gene="fmt" FT /locus_tag="Mb1441" FT /product="PROBABLE METHIONYL-TRNA FORMYLTRANSFERASE FMT" FT /EC_number="2.1.2.9" FT /note="Mb1441, fmt, len: 312 aa. Equivalent to Rv1406, len: FT 312 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 312 aa overlap). Probable fmt, methionyl-tRNA FT formyltransferase (EC 2.1.2.9), similar to many e.g. FT FMT_ECOLI|P23882 Escherichia coli (314 aa), FASTA scores: FT opt: 616, E(): 6.7e-31, (39.3% identity in 303 aa overlap). FT BELONGS TO THE FMT FAMILY." FT /db_xref="GOA:P64135" FT /db_xref="HSSP:1FMT" FT /db_xref="InterPro:IPR015518" FT /db_xref="UniProtKB/Swiss-Prot:P64135" FT /protein_id="CAD94302.1" FT /translation="MRLVFAGTPEPALASLRRLIESPSHDVIAVLTRPDAASGRRGKPQ FT PSPVAREAAERGIPVLRPSRPNSAEFVAELSDLAPECCAVVAYGALLGGPLLAVPPHGW FT VNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPIYGVVTEVIQPTDTAG FT DLLKRLAVSGAALLSTTLDGIADQRLTPRPQPADGVSVAPKITVANARVRWDLPAAVVE FT RRIRAVTPNPGAWTLIGDLRVKLGPVHLDAAHRPSKPLPPGGIHVERTSVWIGTGSEPV FT RLGQIQPPGKKLMNAADWARGARLDLAARAT" FT CDS 264808..266181 FT /transl_table=11 FT /gene="fmu" FT /locus_tag="Mb1442" FT /product="PROBABLE FMU PROTEIN (SUN PROTEIN)" FT /note="Mb1442, fmu, len: 457 aa. Equivalent to Rv1407, len: FT 457 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 457 aa overlap). Probable fmu protein, FT similar to SUN_ECOLI|P36929 sun protein (fmu protein) from FT Escherichia coli (429 aa), FASTA scores: E(): 2.5e-20, FT (30.6% identity in 451 aa overlap)." FT /db_xref="GOA:Q7U044" FT /db_xref="InterPro:IPR006027" FT /db_xref="UniProtKB/TrEMBL:Q7U044" FT /protein_id="CAD94303.1" FT /translation="MTPRSRGPRRRPLDPARRAAFETLRAVSARDAYANLVLPALLAQR FT GIGGRDAAFATELTYGTCRARGLLDAVIGAAAERSPQAIDPVLLDLLRLGTYQLLRTRV FT DAHAAVSTTVEQAGIEFDSARAGFVNGVLRTIAGRDERSWVGELAPDAQNDPIGHAAFV FT HAHPRWIAQAFADALGAAVGELEAVLASDDERPAVHLAARPGVLTAGELARAVRGTVGR FT YSPFAVYLPRGDPGRLAPVRDGQALVQDEGSQLVARALTLAPVDGDTGRWLDLCAGPGG FT KTALLAGLGLQCAARVTAVEPSPHRADLVAQNTRGLPVELLRVDGRHTDLDPGFDRVLV FT DAPCTGLGALRRRPEARWRRQPADVAALAKLQRELLSAAIALTRPGGVVLYATCSPHLA FT ETVGAVADALRRHPVHALDTRPLFEPVLAGLGEGPHVQLWPHRHGTDAMFAAALRRLT" FT CDS 266206..266904 FT /transl_table=11 FT /gene="rpe" FT /locus_tag="Mb1443" FT /product="PROBABLE RIBULOSE-PHOSPHATE 3-EPIMERASE RPE (PPE) FT (R5P3E) (Pentose-5-phosphate 3-epimerase)" FT /EC_number="5.1.3.1" FT /note="Mb1443, rpe, len: 232 aa. Equivalent to Rv1408, len: FT 232 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 232 aa overlap). Probable rpe, FT ribulose-phosphate 3-epimerase (EC 5.1.3.1), similar to FT many e.g. CXEC_ALCEU|P40117 (241 aa), FASTA scores: opt: FT 638, E(): 1.5e-34, (48.3% identity in 234 aa overlap); and FT RPE_ECOLI|P32661 ribulose-phosphate 3-epimerase (225 aa), FT FASTA scores: E(): 0, (46.2% identity in 221 aa overlap). FT Contains PS01085 Ribulose-phosphate 3-epimerase family FT signature 1. BELONGS TO THE RIBULOSE-PHOSPHATE 3-EPIMERASE FT FAMILY." FT /db_xref="GOA:P65761" FT /db_xref="HSSP:1H1Y" FT /db_xref="InterPro:IPR000056" FT /db_xref="UniProtKB/Swiss-Prot:P65761" FT /protein_id="CAD94304.1" FT /translation="MSLMAGSTGGPLIAPSILAADFARLADEAAAVNGADWLHVDVMDG FT HFVPNLTIGLPVVESLLAVTDIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPV FT GVARDIRAAGAKAGISVKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLSKVR FT AVRKMVDAGELTILVEIDGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAALRRQ FT AGAASLHLSL" FT CDS 266901..267920 FT /transl_table=11 FT /gene="ribG" FT /locus_tag="Mb1444" FT /product="PROBABLE BIFUNCTIONAL riboflavin biosynthesis FT protein RIBG : Diaminohydroxyphosphoribosylaminopyrimidine FT deaminase (Riboflavin-specific deaminase) + FT 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP FT reductase)" FT /EC_number="3.5.4.26" FT /EC_number="1.1.1.193" FT /note="Mb1444, ribG, len: 339 aa. Equivalent to Rv1409, FT len: 339 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 339 aa overlap). Probable ribG FT (alternate gene name: ribD), bifunctional riboflavin FT biosynthesis protein, including FT diaminohydroxyphosphoribosylaminopyrimidine deaminase and FT 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC FT 3.5.4.26 and 1.1.1.193), similar to many e.g. FT RIBD_ECOLI|P25539 riboflavin-specific deaminase from FT Escherichia coli (367 aa), FASTA scores: E(): 0, (39.8% FT identity in 364 aa overlap); etc. Contains PS00903 Cytidine FT and deoxycytidylate deaminases zinc-binding region FT signature. IN THE N-TERMINAL SECTION; BELONGS TO THE FT CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. IN THE FT C-TERMINAL SECTION; BELONGS TO THE HTP REDUCTASE FAMILY." FT /db_xref="GOA:Q7U043" FT /db_xref="InterPro:IPR011549" FT /db_xref="UniProtKB/TrEMBL:Q7U043" FT /protein_id="CAD94305.1" FT /translation="MNVEQVKSIDEAMGLAIEHSYQVKGTTYPNPPVGAVIVDPNGRIV FT GAGGTEPAGGDHAEVVALRRAGGLATGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVV FT YAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATS FT IDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAP FT QQPLRVVVGKRDIPPEARVLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAF FT LRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR" FT CDS complement(267917..269473) FT /transl_table=11 FT /gene="Mb1445c" FT /locus_tag="Mb1445c" FT /standard_name="P55" FT /product="AMINOGLYCOSIDES/TETRACYCLINE-TRANSPORT INTEGRAL FT MEMBRANE PROTEIN" FT /note="Mb1445c, -, len: 518 aa. Equivalent to Rv1410c, len: FT 518 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 518 aa overlap). FT Aminoglycoside/tetracycline-transport integral membrane FT protein (see citation below), member of major facilitator FT superfamily (MFS), similar to others e.g. AC22_STRCO|P46105 FT probable actinorhodin transporter from Streptomyces FT coelicolor (578 aa), FASTA scores: opt: 442, E(): 4.9e-21, FT (28.5% identity in 466 aa overlap); etc. Contains PS00216 FT Sugar transport proteins signature 1. Could be termed P55. FT Note that the Rv1410c-Rv1411c operon seems transcribed from FT two promoters in M. bovis BCG (see second citation)." FT /db_xref="GOA:Q7U042" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q7U042" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD94306.1" FT /translation="MRAGRRVAISAGSLAVLLGALDTYVVVTIMR |