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EBI DbfetchID BX248337; SV 1; linear; genomic DNA; STD; PRO; 327650 BP. XX AC BX248337; XX DT 10-JUN-2003 (Rel. 76, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 4/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-327650 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF00174; Cobalamin. XX FH Key Location/Qualifiers FH FT source 1..327650 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS 698..2170 FT /transl_table=11 FT /gene="Mb0912" FT /locus_tag="Mb0912" FT /product="PROBABLE EXPORTED PROTEIN" FT /note="Mb0912, -, len: 490 aa. Equivalent to Rv0888, len: FT 490 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 490 aa overlap). Probable exported FT protein. Equivalent to AAK45157.1 from Mycobacterium FT tuberculosis strain CDC1551 (507 aa) but shorter 17 aa. FT Contains possible N-terminal signal sequence." FT /db_xref="GOA:P64744" FT /db_xref="InterPro:IPR005135" FT /db_xref="UniProtKB/Swiss-Prot:P64744" FT /protein_id="CAD93773.1" FT /translation="MDYAKRIGQVGALAVVLGVGAAVTTHAIGSAAPTDPSSSSTDSPV FT DACSPLGGSASSLAAIPGASVPQVGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPIIEN FT RTPVANPQQVSVPEGGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTAS FT FIYTADPGFVGTDTFSVNVSDDTSLHVHGLAGYLGPFHGHDDVATVTVFVGNTPTDTIS FT GDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAYYVANVQEDFAYHQFLIKKSKM FT PSQTPPEPPTLLWPIGVPFSDGLNTLSEFKVQRLDRQTWYECTSDNCLTLKGFTYSQMR FT LPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVTGDFNARYSDDQSAL FT LQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKIFYRSGQGVTLQAVSYGNE FT APKFFNSKGEPLSDHSPAVVGFHYVADNVAVR" FT CDS complement(2205..3326) FT /transl_table=11 FT /gene="citA" FT /locus_tag="Mb0913c" FT /product="PROBABLE CITRATE SYNTHASE II CITA" FT /EC_number="2.3.3.1" FT /note="Mb0913c, citA, len: 373 aa. Equivalent to Rv0889c, FT len: 373 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 373 aa overlap). Probable citA FT (alternate gene name: gltA), citrate synthase 2 (EC FT 4.1.3.7), highly similar to others e.g. CAB95899.1|AL359988 FT putative citrate synthase from Streptomyces coelicolor (387 FT aa); P39119|CISY_BACSU citrate synthase II from Bacillus FT subtilis (366 aa), FASTA scores: opt: 586, E(): 5.8e-30, FT (33.8% identity in 367 aa overlap); etc. Also similar to FT Rv0896|MTCY31.24 from Mycobacterium tuberculosis (29.2% FT identity in 274 aa overlap) and Rv1131. Contains PS00480 FT Citrate synthase signature. BELONGS TO THE CITRATE SYNTHASE FT FAMILY." FT /db_xref="GOA:P63778" FT /db_xref="HSSP:1A59" FT /db_xref="InterPro:IPR019810" FT /db_xref="UniProtKB/Swiss-Prot:P63778" FT /protein_id="CAD93774.1" FT /translation="MTVVPENFVPGLDGVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQ FT RVTFGDVWALLVDGNFGSGLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLLDID FT DATARQQLARASVMALSYVAQSARGIYQPAVPQRIIDECSTVTARFMTRWQGEPDPRHI FT EAIDAYWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARVLPML FT DEVERAGDARSVVKGILDRGEKLMGFGHRVYRAEDPRARVLRAAAERLGAPRYEVAVAV FT EQAALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCAHILEQK FT RLGKLVRPSAIYVGPGPRSPESVDGWERVLTTA" FT CDS complement(3413..6061) FT /transl_table=11 FT /gene="Mb0914c" FT /locus_tag="Mb0914c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LUXR-FAMILY)" FT /note="Mb0914c, -, len: 882 aa. Equivalent to Rv0890c, len: FT 882 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 882 aa overlap). Probable FT transcriptional regulatory protein, LuxR family, highly FT similar (but shorter 238 aa in N-terminus) to FT NP_302202.1|NC_002677 possible transcriptional regulator FT from Mycobacterium leprae (1106 aa). Also highly similar FT (generally in part) to others e.g. T50568 probable FT multi-domain regulatory protein from Streptomyces FT coelicolor (1334 aa); P10957|NARL_ECOLI nitrate/nitrite FT response regulator protein from Escherichia coli (216 aa), FT FASTA scores: opt: 193, E(): 6e-06, (37.4% identity in 99 FT aa overlap); etc. Also highly similar to others from FT Mycobacterium tuberculosis e.g. MTCY02B10_22, MTV008_44, FT MTV036_21, and MTCY31_24. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop), PS00622 Bacterial regulatory FT proteins, luxR family signature, and probable helix-turn FT helix motif from aa 836 to 857 (Score 1559, +4.50 SD). FT BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL FT REGULATORS." FT /db_xref="GOA:P59969" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P59969" FT /protein_id="CAD93775.1" FT /translation="MRALLAQNRLVTLCGTGGVGKTRLAIQIASASELRDGLCFVDLAP FT ITESGIVAATAARAVGLPDQPGRSTMDSLRRFIGNRRMLMVLDNCEHLLDACAALVVEL FT LGACPELTILATSREPIGMAGEITWRVPSMSITDEAVELFADRASRVQPGFTIANHNAA FT AVGEICRRLDGIPLAIEFAAARVRSMSPLEIADGLDDCFRLLAGGVRGAVQRQQTLRAS FT IDWSHALLTETEQILFRRLAPFVGGFDLAAVRAVAAGSDLDPFSVLDQLTLLVDKSLVV FT ADDCQGRTRYRLLETVRRYALEKLGDSGEADVHARHRDYYTALAASLNTPADNDHQRLV FT ARAETEIDNLRAAFAWSRENGHITEALQLASSLQPIWFGRAHLREGLSWFNSILEDQRF FT HRLAVSTAVRARALADKAMLSTWLATSPVGATDIIAPAQQALAMAREVGDPAALVRALT FT ACGCSSGYNAEAAAPYFAEATDLARAIDDKWTLCQILYWRGVGTCISGDPNALRAAAEE FT CRDLADTIGDRFVSRHCSLWLSLAQMWAGNLTEALELSREITAEAEASNDVPTKVLGLY FT TQAQVLAYCGASAAHAIAGACIAAATELGGVYQGIGYAAMTYAALAAGDVTAALEASDA FT ARPILRAQPDQVTMHQVLMAQLALAGGDAIAARQFANDAVDATNGWHRMVALTIRARVA FT TARGEPELARDDAHAALACGAELHIYQGMPDAMELLAGLAGEVGSHSEGVRLLGAAAAL FT RQQTRQVRFKIWDAGYQASVTALREAMGDEDFDRAWAEGAALSTDEAIAYAQRGRGERK FT RPARGWGSLTPTERDVVRLVSEGLSNKDIAKRLFVSPRTVQTHLTHVYAKLGLASRVQL FT VDEAARRGSPS" FT CDS complement(6063..6920) FT /transl_table=11 FT /gene="Mb0915c" FT /locus_tag="Mb0915c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0915c, -, len: 285 aa. Equivalent to Rv0891c, len: FT 285 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 285 aa overlap). Possible FT transcriptional regulator, highly similar in N-terminus to FT NP_302202.1|NC_002677 possible transcriptional regulator FT from Mycobacterium leprae (1106 aa). Also highly similar to FT several Mycobacterium tuberculosis putative transcriptional FT regulators e.g. Q1102|MTCY02B10_22 PROBABLE TRANSCRIPTIONAL FT REGULATORY PROTEIN (1159 aa), FASTA scores: opt: 702, E(): FT 8.3e-40, (50.6% identity in 247 aa overlap); MTV036_21; FT MTV008_44; MTCY02B10_23. Also shows similarity with several FT adenylate cyclases and hydrolases from other organisms." FT /db_xref="GOA:P59970" FT /db_xref="InterPro:IPR001054" FT /db_xref="UniProtKB/Swiss-Prot:P59970" FT /protein_id="CAD93776.1" FT /translation="MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARGRISALGSL FT DLRYHSLRCYAAPPDVGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEESTHL FT WQMCPEDMATAIAHLDHTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALDLQR FT TSLAPIRLRIGLHTGEVQLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVTGRLP FT ADAWLVDLGRHPLRGLPRPEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTTFVGRR FT AQIS" FT CDS 7318..8805 FT /transl_table=11 FT /gene="Mb0916" FT /locus_tag="Mb0916" FT /product="PROBABLE MONOOXYGENASE" FT /EC_number="1.14.-.-" FT /note="Mb0916, -, len: 495 aa. Equivalent to Rv0892, len: FT 495 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 495 aa overlap). Probable monooxygenase FT (EC 1.14.-.-), highly similar to others e.g. FT NP_250787.1|NC_002516 probable flavin-binding monooxygenase FT from Pseudomonas aeruginosa (491 aa); CAB59668.1|AL132674 FT monooxygenase from Streptomyces coelicolor (519 aa); FT P12015|CYMO_ACIS cyclohexanone monooxygenase from FT Acinetobacter sp. (542 aa), FASTA scores: opt: 489, E(): FT 6.8e-26, (30.3% identity in 492 aa overlap); etc. Also FT highly similar to Rv0565c, Rv3854c, Rv3083, etc from FT Mycobacterium tuberculosis. Has hydrophobic stretch at FT N-terminus." FT /db_xref="GOA:P64746" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/Swiss-Prot:P64746" FT /protein_id="CAD93777.1" FT /translation="MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVCIYEKADDVGGTW FT RDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGAT FT VVSARFDDGRWVLRTDSGTESTVDFLISATGVLHHPRIPPIAGLDDFRGTVFHSARWDH FT TVPLLGRRIAVIGTGSTGVQLVCGLAGVAGKVTMFQRTAQWVLPWPNPRYSKLARVFHR FT AFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAVCRASLRRVRDPRLRRALTPDYE FT PMCKRLVMSGGFYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHA FT FFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQ FT AEHIVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYLNKDGIPEV FT WPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA" FT CDS complement(8783..9760) FT /transl_table=11 FT /gene="Mb0917c" FT /locus_tag="Mb0917c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0917c, -, len: 325 aa. Equivalent to Rv0893c, len: FT 325 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 325 aa overlap). Conserved hypothetical FT protein, belongs in family with P96823|Rv0146|MTCI5.20 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (310 aa), FASTA scores: opt: 784, E(): 0, FT (43.2% identity in 308 aa overlap); Rv0726c, Rv0731c, FT Rv3399, etc. Also shows some similarity with others e.g. FT SC9B5.10|T35930 hypothetical protein from Streptomyces FT coelicolor (303 aa); BSUB0008_141|Q45500 HYPOTHETICAL 34.8 FT KD PROTEIN from Bacillus subtilis (304 aa), FASTA scores: FT E(): 0.00033, (26.8% identity in 168 aa overlap); etc." FT /db_xref="GOA:P64748" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/Swiss-Prot:P64748" FT /protein_id="CAD93778.1" FT /translation="MRTEDDSWDVTTSVGSTGLLVAAARALETQKADPLAIDPYAEVFC FT RAAGGEWADVLDGKLPDHYLTTGDFGEHFVNFQGARTRYFDEYFSRATAAGMKQVVILA FT AGLDSRAFRLQWPIGTTIFELDRPQVLDFKNAVLADYHIRPRAQRRSVAVDLRDEWQIA FT LCNNGFDANRPSAWIAEGLLVYLSAEAQQRLFIGIDTLASPGSHVAVEEATPLDPCEFA FT AKLERERAANAQGDPRRFFQMVYNERWARATEWFDERGWRATATPLAEYLRRVGRAVPE FT ADTEAAPMVTAITFVSAVRTGLVADPARTSPSSTSIGFKRFEAD" FT CDS 9989..11170 FT /transl_table=11 FT /gene="Mb0918" FT /locus_tag="Mb0918" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY LUXR-FAMILY)" FT /note="Mb0918, -, len: 393 aa. Equivalent to Rv0894, len: FT 393 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 393 aa overlap). Possible regulatory FT protein, LuxR family, highly similar in part to FT NP_302202.1|NC_002677 possible transcriptional regulator FT from Mycobacterium leprae (1106 aa). Also similar to others FT e.g. CAB95788.1|AL359949 putative multi-domain regulatory FT protein from Streptomyces coelicolor (780 aa); FT NP_107293.1|NC_002678 transcriptional regulator from FT Mesorhizobium loti (903 aa); etc. Also similar to other FT regulatory proteins from Mycobacterium tuberculosis e.g. FT Rv2488c|MTV008_44 (1137 aa), FASTA score: (53.2% identity FT in 363 aa overlap); Rv1358|MTCY02B10_22 (1159 aa), FASTA FT score: (52.3% identity in 365 aa overlap); etc. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:P64750" FT /db_xref="UniProtKB/Swiss-Prot:P64750" FT /protein_id="CAD93779.1" FT /translation="MPSRATVQEFSDSYPFCHNGFRPIMMPKIVSVQHSTRRHLTSFVG FT RKAELNDVRRLLSDKRLVTLTGPDGMGKSRLALQIGAQIAHEFTYGRWDCDLATVTDRD FT CVSISMLNALGLPVQPGLSAIDTLVGVINDARVLLVLDHCEHLLDACAAIIDSLLRSCP FT RLTILTTSTEAIGLAGELTWRVPPLSLTNDAIELFVDRARRVRSDFAINADTAVTVGEI FT CRRLDGVPLAIELAAARTDTLSPVEILAGLNDRFRLVAGAAGNAVRPEQTLCATVQWSH FT ALLSGPERALLHRLAVFAGGFDLDGAQAVGANDEDFEGYQTLGRFAELVDKAFVVVENN FT RGRAGYRLLYSVRQYALEKLSESGEADAVLARYRKHLKQPNQVVRAGSGGVRY" FT CDS 11247..12764 FT /transl_table=11 FT /gene="Mb0919" FT /locus_tag="Mb0919" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0919, -, len: 505 aa. Equivalent to Rv0895, len: FT 505 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 505 aa overlap). Conserved hypothetical FT protein; member of family with: Rv3740c, Rv3734c, Rv1425, FT Rv1760, etc. Shows some similarity with FT NP_301898.1|NC_002677 conserved membrane protein from FT Mycobacterium leprae (491 aa)." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/Swiss-Prot:P67205" FT /protein_id="CAD93780.1" FT /translation="MRQQQEADVVALGRKPGLLCVPERFRAMDLPMAAADALFLWAETP FT TRPLHVGALAVLSQPDNGTGRYLRKVFSAAVARQQVAPWWRRRPHRSLTSLGQWSWRTE FT TEVDLDYHVRLSALPPRAGTAELWALVSELHAGMLDRSRPLWQVDLIEGLPGGRCAVYV FT KVHHALADGVSVMRLLQRIVTADPHQRQMPTLWEVPAQASVAKHTAPRGSSRPLTLAKG FT VLGQARGVPGMVRVVADTTWRAAQCRSGPLTLAAPHTPLNEPIAGARSVAGCSFPIERL FT RQVAEHADATINDVVLAMCGGALRAYLISRGALPGAPLIAMVPVSLRDTAVIDVFGQGP FT GNKIGTLMCSLATHLASPVERLSAIRASMRDGKAAIAGRSRNQALAMSALGAAPLALAM FT ALGRVPAPLRPPNVTISNVPGPQGALYWNGARLDALYLLSAPVDGAALNITCSGTNEQI FT TFGLTGCRRAVPALSILTDQLAHELELLVGVSEAGPGTRLRRIAGRR" FT CDS 12937..14232 FT /transl_table=11 FT /gene="gltA2" FT /locus_tag="Mb0920" FT /product="PROBABLE CITRATE SYNTHASE I GLTA2" FT /EC_number="2.3.3.1" FT /note="Mb0920, gltA2, len: 431 aa. Equivalent to Rv0896, FT len: 431 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8%% identity in 431 aa overlap). Probable gltA2, FT citrate synthase 1 (EC 4.1.3.7), highly similar to FT O33066|NP_302405.1|NC_002677 citrate synthase 1 from FT Mycobacterium leprae (431 aa), FASTA scores: E(): 0, (91.0 FT identity in 431 aa overlap); and FT AAF04133.1|AF191033_1|AF191033 citrate synthase from FT Mycobacterium smegmatis (441 aa). Also highly similar to FT others e.g. AAF14286.1|AF181118_1|AF181118 citrate synthase FT from Streptomyces coelicolor (429 aa); P42457|CISY_CORGL FT CITRATE SYNTHASE from Corynebacterium glutamicum (437 aa), FT FASTA scores: opt: 1847, E(): 0, (63.0% identity in 433 aa FT overlap); etc. Also similar to two other Mycobacterium FT tuberculosis citrate synthases, Rv0889|MTCY31.17c|citA (373 FT aa), FASTA score: (29.2% identity in 274 aa overlap) and FT Rv1131|MTCY22G8.20|gltA1 (393 aa). Contains PS00480 Citrate FT synthase signature. BELONGS TO THE CITRATE SYNTHASE FT FAMILY." FT /db_xref="GOA:Q7U122" FT /db_xref="HSSP:1K3P" FT /db_xref="InterPro:IPR019810" FT /db_xref="UniProtKB/TrEMBL:Q7U122" FT /protein_id="CAD93781.1" FT /translation="MADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTF FT DVGFANTAAAKSSITYIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGELPDTDQLA FT QFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQVELS FT TIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEVVRAL FT DMLFILHADHEQNCSTSTVRLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEGI FT RDSGDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDSLL FT GIAKELEEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHW FT REMHDEGDSKIGRPRQIYTGYAERDYVTIDAR" FT CDS complement(14273..15880) FT /transl_table=11 FT /gene="Mb0921c" FT /locus_tag="Mb0921c" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0921c, -, len: 535 aa. Equivalent to Rv0897c, len: FT 535 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 535 aa overlap). Possible oxidoreductase (EC FT 1.-.-.-), similar to various oxidoreductases from diverse FT organisms e.g. CAB94055.1|AL358672 putative oxidoreductase FT from Streptomyces coelicolor (540 aa); FT NP_147877.1|NC_000854 phytoene dehydrogenase from Aeropyrum FT pernix (549 aa); Q01671|CRTD_RHOSH methoxyneurosporene FT dehydrogenase from Rhodobacter sphaeroides (495 aa), FASTA FT scores: opt: 139, E(): 2.6e-06, (23.8% identity in 538 aa FT overlap); etc. Also similar to Rv1432, Rv2997, and Rv3829c FT from Mycobacterium tuberculosis." FT /db_xref="GOA:P64752" FT /db_xref="InterPro:IPR002218" FT /db_xref="UniProtKB/Swiss-Prot:P64752" FT /protein_id="CAD93782.1" FT /translation="MSDHDRDFDVVVVGGGHNGLVAAAYLARAGLRVRLLERLAQTGGA FT AVSIQAFDGVEVALSRYSYLVSLLPSRIVADLGAPVRLARRPFSSYTPAPATAGRSGLL FT IGPTGEPRAAHLAAIGAAPDAHGFAAFYRRCRLVTARLWPTLIEPLRTREQARRDIVEY FT GGHEAAAAWQAMVDEPIGHAIAGAVANDLLRGVIATDALIGTFARMHEPSLMQNICFLY FT HLVGGGTGVWHVPIGGMGSVTSALATAAARHGAEIVTGADVFALDPDGTVRYHSDGSDG FT AEHLVRGRFVLVGVTPAVLASLLGEPVAALAPGAQVKVNMVVRRLPRLRDDSVTPQQAF FT AGTFHVNETWSQLDAAYSQAASGRLPDPLPCEAYCHSLTDPSILSARLRDAGAQTLTVF FT GLHTPHSVFGDTEGLAERLTAAVLASLNSVLAEPIQDVLWTDAQSKPCIETTTTLDLQR FT TLGMTGGNIFHGALSWPFADNDDPLDTPARQWGVATDHERIMLCGSGARRGGAVSGIGG FT HNAAMAVLACLASRRKSP" FT CDS complement(15906..16169) FT /transl_table=11 FT /gene="Mb0922c" FT /locus_tag="Mb0922c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0922c, -, len: 87 aa. Equivalent to Rv0898c, len: FT 87 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 87 aa overlap). Conserved hypothetical protein, FT highly similar to CAC01589.1|AL391041 hypothetical protein FT from Streptomyces coelicolor (87 aa). Also shows some FT similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium FT tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa FT overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64754" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93783.1" FT /translation="MGKGRKPTDSETLAHIRDLVAEEKALRAQLRHGGISESEEQQQLR FT RIEIELDQCWDLLRQRRALRQTGGDPREAVVRPADQVEGYTG" FT CDS 16277..17257 FT /transl_table=11 FT /gene="ompA" FT /locus_tag="Mb0923" FT /product="PROBABLE OUTER MEMBRANE PROTEIN A OMPA" FT /note="Mb0923, ompA, len: 326 aa. Equivalent to Rv0899, FT len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 326 aa overlap). Probable ompA, outer FT membrane protein A, C-terminal region similar to C-terminus FT of many members of the OMPA family of outer membrane FT proteins e.g. NP_458280.1|NC_003198 putative outer membrane FT protein from Salmonella enterica subsp. enterica serovar FT Typhi (220); NP_418008.1|NC_000913 putative outer membrane FT protein from Escherichia coli strain K12 (219 aa), FASTA FT scores: opt: 296, E(): 2.2e-11, (45.3% identity in 117 aa FT overlap); NP_231844.1|NC_002505 outer membrane protein OmpA FT from Vibrio cholerae (321 aa); Q05146|OMPA_BORAV OUTER FT MEMBRANE PROTEIN A PRECURSOR from Bordetella avium (194 FT aa); etc. A signal peptide sequence probably exists at the FT N-terminus. Contains PS00044 Bacterial regulatory proteins, FT lysR family signature. BELONGS TO THE OMPA FAMILY." FT /db_xref="GOA:P65594" FT /db_xref="InterPro:IPR007055" FT /db_xref="UniProtKB/Swiss-Prot:P65594" FT /protein_id="CAD93784.1" FT /translation="MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAAI FT GYGAFERPQSVTGPTGVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAAKA FT ALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLT FT GTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGP FT IAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIV FT ADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN" FT CDS 17270..17422 FT /transl_table=11 FT /gene="Mb0924" FT /locus_tag="Mb0924" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb0924, -, len: 50 aa. Equivalent to Rv0900, len: 50 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 50 aa overlap). Possible membrane protein, with FT hydrophobic domain from aa 4-26." FT /db_xref="UniProtKB/Swiss-Prot:P64756" FT /protein_id="CAD93785.1" FT /translation="MDFVIQWSCYLLAFLGGSAVAWVVVTLSIKRASRDEGAAEAPSAA FT ETGAQ" FT CDS 17422..17949 FT /transl_table=11 FT /gene="Mb0925" FT /locus_tag="Mb0925" FT /product="POSSIBLE CONSERVED EXPORTED OR MEMBRANE PROTEIN" FT /note="Mb0925, -, len: 175 aa. Equivalent to Rv0901, len: FT 175 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 175 aa overlap). Possible conserved exported or FT membrane protein, with hydrophobic N-terminus at aa 7-25. FT Shows some similarity in C-terminus to FT O33070|Z99494|MLCB57.59 HYPOTHETICAL PROTEIN from FT Mycobacterium leprae (113 aa), FASTA scores: opt: 204, E(): FT 3.2e-12, (44.9% identity in 78 aa overlap)" FT /db_xref="UniProtKB/Swiss-Prot:P64758" FT /protein_id="CAD93786.1" FT /translation="MEHVHWWLAGLAFTLGMVLTSTLMVRPVEHQVLVKKSVRGSSAKS FT KPPTARKPAVKSGTKREESPTAKTKVATESAAEQIPVAGEPAAEPIPVAGEPAARIPVV FT PYAPYGPGSARAGADGSGPQGWLVKGRSDTRLYYTPEDPTYDPTVAQVWFQDEESAARA FT FFTPWRKSTRRT" FT CDS complement(17966..19306) FT /transl_table=11 FT /gene="prrB" FT /locus_tag="Mb0926c" FT /product="TWO COMPONENT SENSOR HISTIDINE KINASE PRRB" FT /EC_number="2.7.3.-" FT /note="Mb0926c, prrB, len: 446 aa. Equivalent to Rv0902c, FT len: 446 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 446 aa overlap). prrB, two-component FT sensor histidine kinase (EC 2.7.3.-) (see citations below), FT transmembrane protein, equivalent to FT MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase FT from Mycobacterium leprae (446 aa); and similar at FT C-termini to NP_301251.1|NC_002677 putative two-component FT system sensor kinase from Mycobacterium leprae (519 aa). FT C-terminus also similar to the C-termini of many FT sensor-like histidine kinase proteins e.g. FT P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor FT protein from Escherichia coli strain K12 (457 aa), FASTA FT scores: opt: 364, E(): 1.7e-15, (27.1% identity in 398 aa FT overlap); CAB89748.1|AL354616 putative two-component FT histidine kinase from Streptomyces coelicolor (483 aa); FT CAB82845.1|AJ277081 putative histidine kinase from FT Amycolatopsis mediterranei (472 aa); etc. Also similar in FT part to Mycobacterium tuberculosis proteins Rv3764c (475 FT aa); and Rv0982 (504 aa). Thought to be induced at FT phagocytosis (see second citation below)." FT /db_xref="GOA:P0A5Z9" FT /db_xref="InterPro:IPR005467" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Z9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93787.1" FT /translation="MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVGTVVWVGITNDR FT KERLDRRLDEAAGFAIPFVPRGLDEIPRSPNDQDALITVRRGNVIKSNSDITLPKLQDD FT YADTYVRGVRYRVRTVEIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAV FT FAWLLAAFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIWNEQN FT RTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVLNDVIRTQSRIE FT ATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAARIYPDLDVSLVPSPTCIIVGLP FT AGLRLAVDNAIANAVKHGGATLVQLSAVSSRAGVEIAIDDNGSGVPEGERQVVFERFSR FT GSTASHSGSGLGLALVAQQAQLHGGTASLENSPLGGARLVLRLPGPS" FT CDS complement(19317..20027) FT /transl_table=11 FT /gene="prrA" FT /locus_tag="Mb0927c" FT /product="TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY FT PROTEIN PRRA" FT /note="Mb0927c, prrA, len: 236 aa. Equivalent to Rv0903c, FT len: 236 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 236 aa overlap). prrA, two-component FT response regulator (see citations below), equivalent to FT Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component FT response regulator from Mycobacterium leprae (233 aa), FT FASTA scores: opt: 1414, E(): 0, (95.7% identity in 233 aa FT overlap); and similar to T45446 probable two-component FT response regulator from Mycobacterium leprae (253 aa). Also FT similar to many sensor-like histidine kinase proteins e.g. FT CAB88489.1|AL353816 putative two-component systen response FT regulator from Streptomyces coelicolor (248 aa); FT AAG36759.1|AF119221_1 |AF119221 response regulator from FT Corynebacterium glutamicum (232 aa); Q02540|COPR_PSESM FT transcriptional activator protein COPR from Pseudomonas FT syringae (pv. tomato) (227 aa), FASTA scores: opt: 600, FT E(): 0, (44.4% identity in 225 aa overlap); etc. Also FT similar to Rv0981 from Mycobacterium tuberculosis (230 aa), FT Rv3765c (234 aa), phoP (247 aa), etc. Thought to be induced FT at phagocytosis (see second citation below)." FT /db_xref="GOA:P0A5Z7" FT /db_xref="HSSP:1B00" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Z7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93788.1" FT /translation="MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAE FT ALRSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAG FT ADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVDVDL FT TKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRL FT LHTVRGVGFVLRMQ" FT CDS complement(20158..21645) FT /transl_table=11 FT /gene="accD3" FT /locus_tag="Mb0928c" FT /product="PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL FT TRANSFERASE (SUBUNIT BETA) ACCD3 (ACCASE BETA CHAIN)" FT /EC_number="6.4.1.2" FT /note="Mb0928c, accD3, len: 495 aa. Equivalent to Rv0904c, FT len: 495 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 495 aa overlap). Putative accD3, FT acetyl-CoA carboxylase carboxyl transferase, beta subunit FT (carboxyltransferase subunit of acetyl-CoA carboxylase) (EC FT 6.4.1.2), highly similar in part to AAA63045.1|U15184 zinc FT finger protein from Mycobacterium leprae (201 aa). Also FT highly similar to others e.g. CAC42827.1|Y17592 putative FT carboxyltransferase subunit of acetyl-CoA carboxylase from FT Corynebacterium glutamicum (491 aa); CAB86110.1|AL163003 FT putative acetyl CoA carboxylase (alpha and beta subunits) FT from Streptomyces coelicolor (458 aa); Q54776|ACCD_SYNP7 FT ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT FT BETA from Synechococcus sp. (305 aa); P12217|ACCD_MARPO FT ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT FT BETA from Marchantia polymorpha (316 aa), FASTA scores: FT opt: 519, E():1.6e-24, (40.2% identity in 219 aa overlap); FT etc. Also similar to Rv3280, Rv2502c, etc from FT Mycobacterium tuberculosis. BELONGS TO THE ACCD/PCCB FT FAMILY." FT /db_xref="GOA:P63406" FT /db_xref="InterPro:IPR011762" FT /db_xref="UniProtKB/Swiss-Prot:P63406" FT /protein_id="CAD93789.1" FT /translation="MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAA FT TGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASP FT SSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVA FT EPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLI FT DAPEPLPAPQTPAPVPDVPTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAAT FT TLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAG FT PALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGW FT LAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFAL FT RLSNAIAAEVHALRKIPAPERLATRLQRYRRIGLPRD" FT CDS 21672..22403 FT /transl_table=11 FT /gene="echA6" FT /locus_tag="Mb0929" FT /product="POSSIBLE ENOYL-COA HYDRATASE ECHA6 (ENOYL FT HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)" FT /EC_number="4.2.1.17" FT /note="Mb0929, echA6, len: 243 aa. Equivalent to Rv0905, FT len: 243 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 243 aa overlap). Possible echA6, FT enoyl-CoA hydratase (EC 4.2.1.17), highly similar to FT ML15184|U15184 enoyl-CoA hydratase from Mycobacterium FT leprae (247 aa), FASTA score: (85.8% identity in 247 aa FT overlap). Also similar to many e.g. NP_250320.1|NC_002516 FT probable enoyl-CoA hydratase/isomerase from Pseudomonas FT aeruginosa (261 aa); NP_415911.1|NC_000913 putative enzyme FT from Escherichia coli strain K12 (255 aa); P24162 FT ECHH_RHOCA|FADB1 enoyl-CoA hydratase homolog from FT Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 FT aa), FASTA scores: opt: 404, E():7.8e-21, (37.3% identity FT in 249 aa overlap); etc." FT /db_xref="GOA:P64015" FT /db_xref="HSSP:1MJ3" FT /db_xref="InterPro:IPR018376" FT /db_xref="UniProtKB/Swiss-Prot:P64015" FT /protein_id="CAD93790.1" FT /translation="MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSAR FT AIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQL FT AMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEIAL FT HTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGS FT QDVIEAQVARMEKRPPKFQGA" FT CDS 22409..23527 FT /transl_table=11 FT /gene="Mb0930" FT /locus_tag="Mb0930" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0930, -, len: 372 aa. Equivalent to Rv0906, len: FT 372 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 372 aa overlap). Conserved hypothetical FT protein, highly similar to others e.g. FT SC6A5.25|AL049485|T35416 hypothetical protein from FT Streptomyces coelicolor (370 aa), FASTA scores: opt: 1125, FT E(): 0, (51.3% identity in 335 aa overlap); FT NP_242955.1|NC_002570|BH2089 conserved protein from FT Bacillus halodurans (370 aa); etc. Also shows some FT similarity to C-terminus of Q48412|ROMA_KLEPN Q48412 outer FT membrane protein roma (fragment) from Klebsiella pneumoniae FT (132 aa), FASTA scores: opt: 319, E(): 8.5e-14, (46.2% FT identity in 104 aa overlap); NP_105215.1|NC_002678 FT hypothetical protein which contains similarity to outer FT membrane protein romA from Enterobacter cloacae (350 aa); FT etc." FT /db_xref="UniProtKB/Swiss-Prot:P64760" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93791.1" FT /translation="MVRRALRLAAGTASLAAGTWLLRALHGTPAALGADAASIRAVSEQ FT SPNYRDGAFVNLDPASMFTLDREELRLIVWELVARHSASRPAAPIPLASPNIYRGDASR FT LAVSWFGHSTALLEIDGYRVLTDPVWSDRCSPSDVVGPQRLHPPPVQLAALPAVDAVVI FT SHDHYDHLDIDTVVALVGMQRAPFLVPLGVGAHLRSWGVPQDRIVELDWNQSAQVDELT FT VVCVPARHFSGRFLSRNTTLWASWAFVGPNHRAYFGGDTGYTKSFTQIGADHGPFDLTL FT LPIGAYNTAWPDIHMNPEEAVRAHLDVTDSGSGMLVPVHWGTFRLAPHPWGEPVERLLA FT AAEPEHVTVAVPLPGQRVDPTGPMRLHPWWRL" FT CDS 23650..25200 FT /transl_table=11 FT /gene="Mb0931" FT /locus_tag="Mb0931" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0931, -, len: 516 aa. Equivalent to Rv0907, len: FT 532 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 511 aa overlap). Conserved hypothetical FT protein, possibly involved in cell wall biosynthesis: FT similar to many beta-lactamases, penicillin-binding FT proteins and hypothetical proteins e.g. FT NP_298910.1|NC_002488 beta-lactamase from Xylella FT fastidiosa (455 aa); Q06317|PBP4_NOCLA PENICILLIN-BINDING FT PROTEIN 4 (PBP-4) (381 aa), FASTA scores: opt: 299, E(): FT 8.8e-05, (28.7% identity in 401 aa overlap); etc. FT N-terminus highly similar to AAA63047.1|U15184 hypothetical FT protein from Mycobacterium leprae (58 aa). Related to other FT putative esterases and penicillin binding proteins in FT Mycobacterium tuberculosis e.g. Rv1730c|MTCY04C12.15c (517 FT aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT a frameshift due to a single base insertion (*-g) leads to FT a shorter product with a different NH2 part compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv." FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q7U121" FT /protein_id="CAD93792.1" FT /translation="MMLLTLTGCGSTHQALGPPSGLPDASPNERSAIQIPAGRIDDAVA FT KVDGLVGELMQNTGIPGMAVAIVHGGKTLYAKGFGVRDVGKGGGPDNKVDADTVFQLAS FT VSKSVGATVVAHAVTDNVVTWDTPVVSKLPWFALRDPYVTGQVTIADLYSHRSGLPDHA FT GDLLEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFGVTAAAEAVAAAAGQSWEDLSDEV FT LYRPLGMGSTSSRFTDFLARPNHAVNHVKVADRWEARYQRDPDAQSPAGGVSSSLNDMT FT HWLAMVLADGVYNGRRITSPEALLLVYTPQVISRHPVSPRARASFYGYGFNVGVTSSGR FT TEYSHSGAFGLGAAANFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQVREDW FT AALYKKAFAPLNELAGSLVGKQSPANPAPSRPLNDYVGVYANDYWGPATVTYHDGQLRL FT SLGPKNQTFDLTHWDGDTFTFTLSTENALPGSISKATFAGDTLNLEYYDADKLGTFTR" FT CDS 25197..27590 FT /transl_table=11 FT /gene="ctpE" FT /locus_tag="Mb0932" FT /product="PROBABLE METAL CATION TRANSPORTER ATPASE P-TYPE FT CTPE" FT /EC_number="3.6.1.-" FT /note="Mb0932, ctpE, len: 797 aa. Equivalent to Rv0908, FT len: 797 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 797 aa overlap). Probable ctpE, metal FT cation-transporting ATPase P-type, transmembrane protein, FT E1-E2 family, highly similar to many e.g. FT AB93406.1|AL357524 putative integral membrane ATPase from FT Streptomyces coelicolor (802 aa); NP_346063.1|NC_003028 FT cation-transporting ATPase (E1-E2 family) from FT Streptococcus pneumoniae (778 aa); P37278|ATCL_SYNP7|PACL FT cation-transporting atpase from Synechococcus sp. strain FT PCC 7942 (Anacystis nidulans R2) (926 aa), FASTA scores: FT opt: 257, E(): 4.8e-33, (27.7% identity in 905 aa overlap); FT etc. Contains E1-E2 ATPases phosphorylation site (PS00154). FT BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 FT ATPASES)." FT /db_xref="GOA:P0A505" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:P0A505" FT /protein_id="CAD93793.1" FT /translation="MTRSASATAGLTDAEVAQRVAEGKSNDIPERVTRTVGQIVRANVF FT TRINAILGVLLLIVLATGSLINGMFGLLIIANSVIGMVQEIRAKQTLDKLAIIGQAKPL FT VRRQSGTRTRSTNEVVLDDIIELGPGDQVVVDGEVVEEENLEIDESLLTGEADPIAKDA FT GDTVMSGSFVVSGAGAYRATKVGSEAYAAKLAAEASKFTLVKSELRNGINRILQFITYL FT LVPAGLLTIYTQLFTTHVGWRESVLRMVGALVPMVPEGLVLMTSIAFAVGVVRLGQRQC FT LVQELPAIEGLARVDVVCADKTGTLTESGMRVCEVEELDGAGRQESVADVLAALAAADA FT RPNASMQAIAEAFHSPPGWVVAANAPFKSATKWSGVSFRDHGNWVIGAPDVLLDPASVA FT ARQAERIGAQGLRVLLLAAGSVAVDHAQAPGQVTPVALVVLEQKVRPDARETLDYFAVQ FT NVSVKVISGDNAVSVGAVADRLGLHGEAMDARALPTGREELADTLDSYTSFGRVRPDQK FT RAIVHALQSHGHTVAMTGDGVNDVLALKDADIGVAMGSGSPASRAVAQIVLLNNRFATL FT PHVVGEGRRVIGNIERVANLFLTKTVYSVLLALLVGIECLIAIPLRRDPLLFPFQPIHV FT TIAAWFTIGIPAFILSLAPNNERAYPGFVRRVMTSAVPFGLVIGVATFVTYLAAYQGRY FT ASWQEQEQASTAALITLLMTALWVLAVIARPYQWWRLALVLASGLAYVVIFSLPLAREK FT FLLDASNLATTSIALAVGVVGAATIEAMWWIRSRMLGVKPRVWR" FT CDS 28147..28326 FT /transl_table=11 FT /gene="Mb0933" FT /locus_tag="Mb0933" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0933, -, len: 59 aa. Equivalent to Rv0909, len: 59 FT aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% FT identity in 59 aa overlap). Conserved hypothetical protein, FT equivalent to NP_302399.1|NC_002677 conserved hypothetical FT protein from Mycobacterium leprae (56 aa). Also some FT similarity with AL022268|SC4H2_10c HYPOTHETICAL PROTEIN FT from Streptomyces coelicolor (97 aa), FASTA scores: opt: FT 106, E(): 0.13, (43.2% identity in 37 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U120" FT /protein_id="CAD93794.1" FT /translation="MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQ FT DAASNVVGMSDQQS" FT CDS 28332..28766 FT /transl_table=11 FT /gene="Mb0934" FT /locus_tag="Mb0934" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0934, -, len: 144 aa. Equivalent to Rv0910, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 144 aa overlap). Conserved hypothetical FT protein, equivalent to NP_302398.1|NC_002677 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa), FT FASTA scores: opt: 820, E(): 0, (83.9% identity in 143 aa FT overlap). Also similar to Rv1546|MTCY48.19c HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (143 aa)." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/TrEMBL:Q7U119" FT /protein_id="CAD93795.1" FT /translation="MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVL FT EKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLNGDGVGGVKVKLIAKVAPKEHGSVV FT SFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG" FT CDS 28864..29637 FT /transl_table=11 FT /gene="Mb0935" FT /locus_tag="Mb0935" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0935, -, len: 257 aa. Equivalent to Rv0911, len: FT 257 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 257 aa overlap). Conserved hypothetical FT protein, showing similarity with hydroxylases and FT hypothetical proteins e.g. T35325 probable hydroxylase from FT Streptomyces coelicolor (265 aa); Q54242 hypothetical FT protein from Streptomyces, FASTA scores: opt: 372, E(): FT 8.8e-18, (32.0% identity in 256 aa overlap); FT AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV from FT Streptomyces peucetius (275 aa); AAA63051.1|U15184 FT hypothetical protein from Mycobacterium leprae (94 aa); FT etc. Also similar to Rv0577 HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (261 aa)." FT /db_xref="InterPro:IPR004360" FT /db_xref="UniProtKB/TrEMBL:Q7U118" FT /protein_id="CAD93796.1" FT /translation="MPTRSSAPLGAPCWIDLTTSDVDRAQDFYGTVFGWAFESAGPDYG FT GYINAAKGGHPVAGLMANRPEFQSPDGWATYFHTVDIGATVAKLAAAGGSSCLDPMEVP FT GKGFMSLAVDPSGAAFGLWQPLQHHGFEVIGEAGSPVWHQLTTRDYRSVIDFYRQVFGW FT RTEQISDTDEFCYTTAWFDDQQLLGVMDGSSCLPEGVPSNWTIFFGAEDVDETLRVICD FT NGGSVVRAAENTPYGRLAAAADPMGVVFNLSSLQA" FT CDS 29702..30151 FT /transl_table=11 FT /gene="Mb0936" FT /locus_tag="Mb0936" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0936, -, len: 149 aa. Equivalent to Rv0912, len: FT 149 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 149 aa overlap). Probable conserved FT transmembrane protein, equivalent to FT Q50121|NP_302397.1|NC_002677 conserved hypothetical protein FT from Mycobacterium leprae (144 aa), FASTA scores: opt: 677, FT E(): 6.9e-38, (69.5% identity in 141 aa overlap)." FT /db_xref="GOA:Q7U117" FT /db_xref="UniProtKB/TrEMBL:Q7U117" FT /protein_id="CAD93797.1" FT /translation="MTRRLRPGWLVALSAAVIAASTWMPWLTTTVGGGGWVNAIGGTHG FT SLELPHGFGPGQLIVLLSSTLLVVGAMAGRGLSVKLSSIAALVVSLLIVALTVWYYKLN FT VNPPVSAEYGLYFGAAGGVCAVGCSLWAAVSAASPGRRRHREVVR" FT CDS complement(30683..32191) FT /transl_table=11 FT /gene="Mb0937c" FT /locus_tag="Mb0937c" FT /product="POSSIBLE DIOXYGENASE" FT /EC_number="1.-.-.-" FT /note="Mb0937c, -, len: 502 aa. Equivalent to Rv0913c, len: FT 502 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 502 aa overlap). Possible dioxygenase FT (EC 1.-.-.-), showing similarity with others e.g. FT AAK38744.1|AY029525 carotenoid 9,10-9',10' cleavage FT dioxygenase from Phaseolus vulgaris (543 aa); FT CAB56138.1|AL117669 putative dioxygenase from Streptomyces FT coelicolor (503 aa); AAK06796.1|AF324838_15|AF324838 FT putative dioxygenase SimC5 from Streptomyces antibioticus FT (456 aa); Q53353|S65040 FT LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE (EC 1.13.11.43) from FT Pseudomonas paucimobilis (485 aa), FASTA scores: opt: 310, FT E(): 3.4e-20, (28.9% identity in 495 aa overlap); etc. Also FT some similarity with Rv0654|MTCI376.22 PROBABLE DIOXYGENASE FT from Mycobacterium tuberculosis (501 aa)." FT /db_xref="GOA:Q7U116" FT /db_xref="InterPro:IPR004294" FT /db_xref="UniProtKB/TrEMBL:Q7U116" FT /protein_id="CAD93798.1" FT /translation="MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEV FT PADLDGIYLRNTENPLHPAFATYHPFDGDGMIHVVGFRDGKAFYRNRFIRTDGFLAENE FT AGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHRGIALTSFYQCGDLYRIDPY FT SANTLGKESWHGRFPFDWGVSAHPKVDNKTGELLFFNYSKQEPYMRYGVVDQNNELVHY FT VDVPLPGPRLLHDMAFTENYVILNDFPLFWDPRLLERDVHLPRFYPEIPSRFAVVARRG FT NDIRWFEADPTFVLHFTNAYEQGDEIVLDGFYEGDPQPLDTGGTKWEKLFRFLALDRLQ FT SRLHRWRLNMVTGAVHEEQLSESITEFGTINADYAASSYRYTYAATGKPSWFLFDGLVK FT HDLLTGNHECYSFGDGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAAR FT PGDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL" FT CDS complement(32193..33431) FT /transl_table=11 FT /gene="Mb0938c" FT /locus_tag="Mb0938c" FT /product="POSSIBLE LIPID CARRIER PROTEIN OR KETO ACYL-COA FT THIOLASE" FT /EC_number="2.3.1.16" FT /note="Mb0938c, -, len: 412 aa. Equivalent to Rv0914c, len: FT 412 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 412 aa overlap). Possible lipid carrier protein FT or keto acyl-CoA thiolase (EC 2.3.1.16), highly similar to FT NP_421905.1|NC_002696 thiolase family protein from FT Caulobacter crescentus (407 aa); and similar to others e.g. FT NP_107896.1|NC_002678 3-ketoacyl-CoA thiolase from FT Mesorhizobium loti (392 aa); NP_385796.1|NC_003047 PUTATIVE FT 3-KETOACYL-COA THIOLASE PROTEIN from Sinorhizobium meliloti FT (389 aa); NP_275932.1|NC_000916 lipid-transfer protein FT (sterol or nonspecific) from Methanothermobacter FT thermautotrophicus (383 aa); AB55378.1|AL117263 possible FT 3-ketoacyl-CoA thiolase from Leishmania major (441 aa), FT FASTA scores: opt: 547, E(): 3.1e-26, (31.0% identity in FT 435 aa overlap); etc. Also similar to Rv2790c, Rv1627c, FT Rv0244, etc from Mycobacterium tuberculosis. COULD BELONG FT TO THE THIOLASE FAMILY." FT /db_xref="GOA:Q7U115" FT /db_xref="InterPro:IPR002155" FT /db_xref="UniProtKB/TrEMBL:Q7U115" FT /protein_id="CAD93799.1" FT /translation="MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVDA FT ADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDDLWDTPATRHEAACASGSVATLAAM FT ADLRSGAYRVALVVGLELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVADEY FT DRRYGLDDTHLRAIAQLNFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCS FT QMTDGGAGLVLVSDAYLRDHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLP FT HVRATVLDALRRARVTLDDLDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGEIEI FT GGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTA FT TTVSFVVSTTRGS" FT CDS complement(33524..34795) FT /transl_table=11 FT /gene="PPE14" FT /locus_tag="Mb0939c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0939c, PPE14, len: 423 aa. Equivalent to Rv0915c, FT len: 423 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 423 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family, highly similar to FT many e.g. Rv1807 from Mycobacterium tuberculosis (403 aa), FT FASTA scores: opt: 966, E(): 4.4e-30, (45.7% identity in FT 392 aa overlap); etc. Contains PS00626 Regulator of FT chromosome condensation (RCC1) signature 2." FT /db_xref="InterPro:IPR000408" FT /db_xref="UniProtKB/TrEMBL:Q7U114" FT /protein_id="CAD93800.1" FT /translation="MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVSY FT GSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETATQARAAAEAFGTAFAMT FT VPPSLVAANRSRLMSLVAANILGQNSAAIAATQAEYAEMWAQDAAVMYSYEGASAAASA FT LPPFTPPVQGTGPAGPAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADP FT LTSGLLGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHI FT GLYGNAGGLGPTQGHPLSSATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVPHSWTTA FT APEIQLAVQATPTFSSSAGADPTALNGMPAGLLSGMALASLAARGTTGGGGTRSGTSTD FT GQEDGRKPPVVVIREQPPPGNPPR" FT CDS complement(34810..35109) FT /transl_table=11 FT /gene="PE7" FT /locus_tag="Mb0940c" FT /product="PE FAMILY PROTEIN" FT /note="Mb0940c, PE7, len: 99 aa. Equivalent to Rv0916c, FT len: 99 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 99 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, similar to many e.g. FT Rv1788 from Mycobacterium tuberculosis (99 aa), FASTA FT scores: opt: 321, E(): 1.3e-11, (53.5% identity in 99 aa FT overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U113" FT /protein_id="CAD93801.1" FT /translation="MSFVTIQPVVLAAATGDLPTIGTAVSARNTAVCAPTTGVLPPAAN FT DVSVLTAARFTAHTKHYRVVSKPAALVHGMFVALPAATADAYATTEAVNVVATG" FT CDS 35553..37334 FT /transl_table=11 FT /gene="betP" FT /locus_tag="Mb0941" FT /product="POSSIBLE GLYCINE BETAINE TRANSPORT INTEGRAL FT MEMBRANE PROTEIN BETP" FT /note="Mb0941, betP, len: 593 aa. Equivalent to Rv0917, FT len: 593 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 593 aa overlap). Possible betP, glycine FT betaine transporter, integral membrane protein, highly FT similar to many transporters, mainly glycine betaine FT transporters, e.g. P54582|BETP_CORGL glycine betaine FT transporter from Corynebacterium glutamicum (Brevibacterium FT flavum) (595 aa), FASTA scores: opt: 1367, E(): 0, (42.7% FT identity in 504 aa overlap); T35264 probable BCCT family FT transporter from Streptomyces coelicolor (578 aa); FT NP_243511.1|NC_002570 glycine betaine transporter from FT Bacillus halodurans (504 aa); NP_439848.1|NC_000907 FT high-affinity choline transport protein (betT) from FT Haemophilus influenzae (669 aa); etc. SEEMS TO BELONG TO FT THE BCCT (TC 2.33) FAMILY OF TRANSPORTERS." FT /db_xref="GOA:P63696" FT /db_xref="InterPro:IPR018093" FT /db_xref="UniProtKB/Swiss-Prot:P63696" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93802.1" FT /translation="MSAKERGDQNAVVDALRSIQPAVFIPASVVIVAMIVVSVVYSSVA FT ENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFSFWAWLA FT MLFSAGMGIGLVFYGVAEPLSHYLRPPRSRGVPALTDAAANQAMALTVFHWGLHAWAIY FT VVVGLGMAYMTYRRGRPLSVRWLLEPVVGRGRVEGALGHAVDVIAIVGTLFGVATSLGF FT GITQIASGLEYLGWIRVDNWWMVGMIAAITATATASVVSGVSKGLKWLSNINMALAAAL FT ALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDGWLGDWTIFYWGWWISWA FT PFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNGDMLVNGAVD FT TNTSLFRLLDGLPIGAITSVLAVLVIVFFFVTSSDSGSLVIDILSAGGELDPPKLTRVY FT WAVLEGVAAAVLLLIGGAGSLTALRTAAIATALPFSIVMVVACYAMTKAFHFDLAATPR FT LLHVTVPDVVAAGNRRRHDISATLSGLIAVRDVDSGTYIVHPDTGALTVTAPPDPLDDH FT VFESDRHVTRRNTTSSR" FT CDS 37677..38153 FT /transl_table=11 FT /gene="Mb0942" FT /locus_tag="Mb0942" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0942, -, len: 158 aa. Equivalent to Rv0918, len: FT 158 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 158 aa overlap). Conserved hypothetical FT protein, similar in part to Q50116 hypothetical protein FT from Mycobacterium leprae (44 aa), FASTA scores: opt: 132, FT E(): 0.0055, (65.6% identity in 32 aa overlap). Also some FT similarity in C-terminus with other hypothetical proteins FT e.g. NP_289961.1|NC_002655 hypothetical protein from FT Escherichia coli strain O157:H7 (94 aa); etc." FT /db_xref="InterPro:IPR014795" FT /db_xref="UniProtKB/TrEMBL:Q7U112" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93803.1" FT /translation="MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLG FT GSGLPALNCTPIRHTIDVMATKPERKTERLAARLTPEQDALIRRAAEAEGTDLTNFTVT FT AALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG" FT CDS 38150..38650 FT /transl_table=11 FT /gene="Mb0943" FT /locus_tag="Mb0943" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0943, -, len: 166 aa. Equivalent to Rv0919, len: FT 166 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 166 aa overlap). Conserved hypothetical FT protein, some similarity to Q50115 hypothetical protein FT from Mycobacterium leprae (90 aa), FASTA scores: opt: 243, FT E(): 5.3e-11, (56.5% identity in 85 aa overlap)." FT /db_xref="GOA:Q7U111" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q7U111" FT /protein_id="CAD93804.1" FT /translation="MSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRC FT FVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPDPVPVILLSRLAVDRKEQGRGLGSH FT LLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDARAL FT IGD" FT tRNA complement(38787..38859) FT /gene="argT" FT /locus_tag="argT" FT /note="argT, len: 73 nt. Equivalent to argT, len: 73 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 73 nt overlap). tRNA-Arg, anticodon cct." FT repeat_region 38924..38938 FT /rpt_type=INVERTED FT /note="15 bp perfect inverted repeat, IRR, ATTCGGTGTAAGTGG, FT flanking IS element IS1554." FT repeat_region complement(38924..40359) FT /mobile_element="insertion sequence:IS1554" FT /locus_tag="IS1554" FT /note="IS1554, len: 1436 nt. Equivalent to IS1554, len: FT 1436 nt, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1436 nt overlap). Putative IS element FT bounded by 15 bp inverted repeats." FT CDS complement(38963..40282) FT /transl_table=11 FT /gene="Mb0944c" FT /locus_tag="Mb0944c" FT /product="PUTATIVE TRANSPOSASE" FT /note="Mb0944c, -, len: 439 aa. Equivalent to Rv0920c, len: FT 439 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 439 aa overlap). Probable transposase FT for IS1554, highly similar to others e.g. MTCY441.35|Q45111 FT transposase from Mycobacterium tuberculosis (419 aa), FASTA FT scores: opt: 1113, E(): 0, (43.9% identity in 378 aa FT overlap); etc. Contains transposases mutator family FT signature (PS01007)." FT /db_xref="GOA:Q7U110" FT /db_xref="InterPro:IPR001207" FT /db_xref="UniProtKB/TrEMBL:Q7U110" FT /protein_id="CAD93805.1" FT /translation="MDAAQVIEPAHAGQDVDEAAVAARELSGAERALVGDLVRQARAEG FT VALTGPDGLLKALTKTVLEAALQEEMTEHLGYDRHAAAGRGSGNSRNGSRNKKVITDAC FT GQVEIAVPRDRNGTFEPVIVGKRKRRVTDVDRVVLSLYAKGLTTGEIAAHFADVYGVSV FT SKDTISRITDRVIEEMQAWWSRPLEKVYAAVFIDAIMVKIRDGQVRNRPVYAAIGVDLD FT GHKDILGMWAGEGDGESAKFWLAVLTELRNRGVKDIFFLVCDGLKGLPDSVSAAFPLAT FT VQTCIIHLIRNTFRYASRKYWDKISVDLKPIYTAASAAEARLRYEEFAEKWGKPYPAIT FT RLWDSAWEEFIPFLDYDVEIRRVPCSTNAIESLNARYRRAVRARGHFPNEQSALKTLYL FT VTRSLDPKGTGQTKWAVRWKPALNALAITFADRMPAAEER" FT repeat_region complement(40345..40359) FT /rpt_type=INVERTED FT /note="15 bp perfect inverted repeat, IRL, ATTCGGTGTAAGTGG, FT flanking IS element IS1554." FT repeat_region 40507..40555 FT /rpt_type=INVERTED FT /note="49 bp imperfect inverted repeat, IRL, FT GGGTTCAGAGCTGTTGCGTGTTGAGTGTGTTTTAGTGTGCGTTAGTGTG, flanking FT IS element IS1535." FT repeat_region 40507..42829 FT /mobile_element="insertion sequence:IS1535" FT /locus_tag="IS1535" FT /note="IS1535, len: 2323 nt. Equivalent to IS1535, len: FT 2300 nt, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 2300 nt overlap). Putative IS element FT bounded by 16 bp inverted repeats." FT repeat_region 40526..40542 FT /rpt_type=INVERTED FT /note="17 bp perfect inverted repeat, IRL, FT GTTGAGTGTGTTTTAGT, flanking IS element IS1535." FT CDS 40570..41151 FT /transl_table=11 FT /gene="Mb0945" FT /locus_tag="Mb0945" FT /product="POSSIBLE RESOLVASE" FT /note="Mb0945, -, len: 193 aa. Equivalent to Rv0921, len: FT 193 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 193 aa overlap). Possible resolvase for IS1535, FT highly similar to many bacterial resolvases e.g. FT MTCY274.17c|YX1C_MYCTU Q10831 from Mycobacterium FT tuberculosis (295 aa), FASTA scores: opt: 537, E(): FT 5.7e-29, (51.8% identity in 166 aa overlap). Presents an FT helix turn helix motif." FT /db_xref="GOA:Q7U109" FT /db_xref="InterPro:IPR006119" FT /db_xref="UniProtKB/TrEMBL:Q7U109" FT /protein_id="CAD93806.1" FT /translation="MNLADWAESVGVNRHTAYRWFREGTLPVPAERVGRLILVKTAASA FT SAAAAGVVLYARVSSHDRRSDLDRQVARLTAWATERDLGVGQVVCEVGSGLNGKRPKLR FT RILSDPDARVIVVEHRDRLARFGVEHLEAALSAQGRRIVVADPGETTDDLVCDMIEVLT FT GMCARLYGRRGARNRAMRAVTEAKREPGAG" FT CDS 41151..42803 FT /transl_table=11 FT /gene="Mb0946" FT /locus_tag="Mb0946" FT /product="PUTATIVE TRANSPOSASE" FT /note="Mb0946, -, len: 550 aa. Equivalent to Rv0922, len: FT 550 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 550 aa overlap). Possible transposase for FT IS1535, similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c FT from Mycobacterium tuberculosis (460 aa), FASTA scores: opt FT 939, E(): 0, (40.6% identity in 465 aa overlap); etc." FT /db_xref="InterPro:IPR010095" FT /db_xref="UniProtKB/TrEMBL:Q7U108" FT /protein_id="CAD93807.1" FT /translation="MIVRMRSCAQAAKVAEATGGVQLAGKPKPDGTPTFSRYVEIGVDF FT EAHRPVVESVSVLFELYDGDANSYAATGGPGAQLPSGWMVTAAKFEVEWPADPQRAGLV FT RSHFGARRKAFNWGLAQVKADLDAKAADPAHESVDWDLKSLRWAWNRAKDDVAPWWAEN FT SKECYSSGLADLAQGLANWKAGKNGTRKGRRVGFPRFKSGRRDPGRVRFTTGTMRIEDD FT RRTITVPVIGPLRAKENTRRVQRHLVSGRAQILNMTLSQRWGRLFVAVCYALRTPTTRS FT PLTQPTVRAGMDLGVRTLATVATLDTATGEQTIIEYPNPAPLKATLVARRRAGRELSRR FT IPGSHGHRAVKAKLARLDRRCVHLRREAAHQLTTELAGTYGQVVIEDLDVAAMKRSMRR FT RAFRRSVSDAAMGLVAPQLAYKTAKCSGVLTVADRWFASSQIHHGCTSPDGTPCRLQGK FT GRIDKHLLCPVTGEVVDRDRNAALNLRDWPDNASRGPVGTTAPSAPGPTTTVGTGHGAD FT TGSSGAGGASVRPRPRRAGRGEAKTQTPQGDAA" FT repeat_region complement(42782..42829) FT /rpt_type=INVERTED FT /note="49 bp imperfect inverted repeat, IRR, FT CCGTTGAGTGTGTTTTAGTTGCACTCTCATGCGGCGTCCCCTTTGCGGG, flanking FT IS element IS1535." FT repeat_region complement(42811..42827) FT /rpt_type=INVERTED FT /note="17 bp perfect inverted repeat, IRR, FT GTTGAGTGTGTTTTAGT, flanking IS element IS1535." FT CDS complement(42979..44043) FT /transl_table=11 FT /gene="Mb0947c" FT /locus_tag="Mb0947c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0947c, -, len: 354 aa. Equivalent to Rv0923c, len: FT 354 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 354 aa overlap). Conserved hypothetical FT protein, showing similarity with C-terminal part of FT AF034138|AF034138_7|yjoB HYPOTHETICAL PROTEIN from Bacillus FT subtilis (200 aa), FASTA scores: opt: 193, E(): 4.2e-05, FT (32.3% identity in 167 aa overlap)." FT /db_xref="InterPro:IPR008585" FT /db_xref="UniProtKB/TrEMBL:Q7U107" FT /protein_id="CAD93808.1" FT /translation="MPDRRHPYFAYGSNLCAHQMASRCPDAGAPRPAVLSDHNWLINQR FT GVATVEPFAGNKVHGVLWQLSERDLVRLDSAEGVPVRYRRERLTVHTDDTALPAWVYID FT HRVMPGRPRPGYLPRVIDGARHHGLPQRWIDYLHRWDPARWPLPVLPSSRSGPAPQSLS FT ELLSQPGVIETSQLRSRFGFLAIHGGGLEQVTDLIAERSAEAAGASVYLLRHPDNYPHH FT LPSARFDPAESARLAEFLDHVDVAVSLHGYDRIGRSTQLLAGGRNRALAAHLARHIQLP FT GYRVVTDLAAIPEELRGLHPDNPVNRVRDGGTQLELSIRVRGLGPRSTLPGVGGMSPVT FT ATLVQGLVTAARSW" FT CDS complement(44044..46098) FT /transl_table=11 FT /gene="mntH" FT /locus_tag="Mb0948c" FT /standard_name="Nramp; Mramp" FT /product="DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE FT PROTEIN MNTH (BRAMP) (MRAMP)" FT /note="Mb0948c, mntH, len: 685 aa. Similar to Rv0924c FT (mntH) and Rv0925c, len: 428 aa and 245 aa, from FT Mycobacterium tuberculosis strain H37Rv, (100% identity in FT 428 aa overlap and 93.2% identity in 237 aa overlap). mntH FT (alternative gene name: Nramp, Mramp), H+-dependent FT divalent cation-transport integral membrane protein (see FT citations below), equivalent to O69443|MNTH_MYCBO PROBABLE FT MANGANESE TRANSPORT PROTEIN MNTH (BRAMP) from Mycobacterium FT bovis (415 aa); and NP_302396.1|NC_002677 probable FT manganese transport protein from Mycobacterium leprae (426 FT aa). Also similar (but longer 51 aa in N-terminus) to FT AAA63075.1|U15184 SMF2 protein from Mycobacterium leprae FT (377 aa), FASTA scores: opt: 1780, E(): 0, (74.5% identity FT in 376 aa overlap). Also similar to many orthologues of the FT eukaryotic Nramp (natural resistance-associated macrophage FT protein), also known as mntH, e.g. NP_456951.1|NC_003198 FT manganese transport protein MntH from Salmonella enterica FT subsp. enterica serovar Typhi (413 aa); etc. BELONGS TO THE FT NRAMP FAMILY. And Conserved hypothetical protein, similar FT to AL132991|SCF55_19 HYPOTHETICAL PROTEIN from Streptomyces FT coelicolor (197 aa), FASTA scores: opt: 459, E(): 1.2e-23, FT (39.3% identity in 201 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0924c and Rv0925c exist as 2 FT genes. In Mycobacterium bovis, a single base deletion (t-*) FT leads to a single product." FT /db_xref="GOA:O69443" FT /db_xref="InterPro:IPR001046" FT /db_xref="UniProtKB/Swiss-Prot:O69443" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93809.1" FT /translation="MTTTSDQNAAAPPRFDGLRALFINATLKRSPELSHTDGLIERSSG FT IMREHGVQVDTLRAVDHDIATGVWPDMTEHGWATDEWPALYRRVLDAHILVLCGPIWLG FT DNSSVMKRVIERLYACSSLLNEDGQYAYYGRAGGCLITGNEDGVKHCAMNVLYSLQHLG FT YTIPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRNTTFMTFNLMHIAQMLRAPAASR FT PTAINAPSGTPAAGRTSPTPTTDSQRRSRVARWLVAGEFRLLSHLCSRGSKVGELAQDT FT RTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLS FT AKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLP FT IGGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPPNAVLGGLA FT PRFQGTESVLLAAAIMGATVMPHAVYLHSGLARDRHGHPDPGPQRRRLLRVTRWDVGLA FT MLIAGGVNAAMLLVAALNMRGRGDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASS FT SVGAYAGAMIMQGLLHWSVPMLVRRLITLGPALAILTLGFDPTRTLVLSQVVLSFGIPF FT AVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNVMLIYLTVTG" FT CDS complement(46175..47251) FT /transl_table=11 FT /gene="Mb0949c" FT /locus_tag="Mb0949c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0949c, -, len: 358 aa. Equivalent to Rv0926c, len: FT 358 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 358 aa overlap). Conserved hypothetical FT protein, similar to Rv1059 CONSERVED HYPOTHETICAL PROTEIN FT from Mycobacterium tuberculosis (354 aa). Also shows some FT similarity to AF170923|AF170923_3 dihydrodipicolinate FT reductase from Mastigocladus laminosus (278 aa), FASTA FT scores: opt: 170, E(): 0.00088, (25.7% identity in 276 aa FT overlap)." FT /db_xref="GOA:Q7U105" FT /db_xref="InterPro:IPR000846" FT /db_xref="UniProtKB/TrEMBL:Q7U105" FT /protein_id="CAD93810.1" FT /translation="MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAA FT ELAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAAGINIVGSG FT PVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFANDLLPMALAGTCESIEQIR FT CMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLLQPGVLSLAWGSVVRQLAAGLGISLDG FT VEEMYVREPAPEAFNIASGHIPKGSAAALRFEVLGLVDGVPAVVLEHVTRLRADLCPEW FT PQPAQPGGSYRIEISGEPCYAMDICLSSRHGDHNHAGLVATAMRIVNAIPAVVAAEPGI FT RTTLDLPLITGEGRYAAA" FT CDS complement(47305..48096) FT /transl_table=11 FT /gene="Mb0950c" FT /locus_tag="Mb0950c" FT /product="PUTATIVE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0950c, -, len: 263 aa. Equivalent to Rv0927c, len: FT 263 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 263 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT dehydrogenases/reductases, notably 7-alpha-hydroxysteroid FT dehydrogenases and glucose 1-dehydrogenases e.g. FT P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from FT Escherichia coli (255 aa), FASTA scores: opt: 551, E(): FT 1e-26, (39.5% identity in 248 aa overlap); FT NP_252778.1|NC_002516 probable short-chain dehydrogenase FT from Pseudomonas aeruginosa (253 aa); AAC44307.1|U59433 FT 3-ketoacyl-acyl carrier protein reductase from Bacillus FT subtilis (246 aa); etc. Also similar to other FT dehydrogenases from Mycobacterium tuberculosis e.g. FT MTCY09F9.36, E():1.4e-18; MTCY369.14, E():8e-17; FT MTCY02B10.14, E():2.5e-14; MTCY09F9.23c, E():1.5e-13; FT MTCY03C7.07, E():1.9e-13. Contains PS00061 Short-chain FT dehydrogenases/reductases family signature, and PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7U104" FT /db_xref="HSSP:1G0N" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U104" FT /protein_id="CAD93811.1" FT /translation="MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSS FT ELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLL FT STSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTA FT KAALAHYTRLAALDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDP FT VDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL" FT CDS 48368..49480 FT /transl_table=11 FT /gene="pstS3" FT /locus_tag="Mb0951" FT /standard_name="phoS2" FT /product="PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS3 FT (PBP-3) (PSTS3) (PHOS1)" FT /note="Mb0951, pstS3, len: 370 aa. Equivalent to Rv0928, FT len: 370 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 370 aa overlap). pstS3 (previously known FT as phoS2), phosphate-binding lipoprotein component of FT inorganic phosphate transport system (see citations below), FT highly similar to others from Mycobacterium leprae e.g. FT Q50099|PSTS3|PHOS1 phosphate-binding protein 3 precursor FT (328 aa), FASTA scores: opt: 1772, E(): 0, (79.6% identity FT in 328 aa overlap); and highly similar to others e.g. FT AAF74819.1|AF137360_1|AF137360 periplasmic phosphate FT permease from Mycobacterium avium (369 aa). Also highly FT similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING FT PERIPLASMIC LIPOPROTEIN (370 aa); and Rv0934|pstS1 FT PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (374 aa) from FT Mycobacterium tuberculosis (Mycobacterium tuberculosis FT seems to have three PstS-like proteins, others being FT Rv0932c and Rv0934c). Contains lipoprotein signature FT (PS00013) at N-terminus. BELONGS TO FAMILY OF PHOSPHATE FT RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS." FT /db_xref="GOA:P0A5Y3" FT /db_xref="HSSP:1IXH" FT /db_xref="InterPro:IPR006059" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Y3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93812.1" FT /translation="MKLNRFGAAVGVLAAGALVLSACGNDDNVTGGGATTGQASAKVDC FT GGKKTLKASGSTAQANAMTRFVNVFEQACPGQTLNYTANGSGAGISEFNGNQTDFGGSD FT VPLSKDEAAAAQRRCGSPAWNLPVVFGPIAVTYNLNSVSSLNLDGPTLAKIFNGSITQW FT NNPAIQALNRDFTLPGERIHVVFRSDESGTTDNFQRYLQAASNGAWGKGAGKSFQGGVG FT EGARGNDGTSAAAKNTPGSITYNEWSFAQAQHLTMANIVTSAGGDPVAITIDSVGQTIA FT GATISGVGNDLVLDTDSFYRPKRPGSYPIVLATYEIVCSKYPDSQVGTAVKAFLQSTIG FT AGQSGLGDNGYIPIPDEFKSRLSTAVNAIA" FT CDS 49493..50467 FT /transl_table=11 FT /gene="pstC2" FT /locus_tag="Mb0952" FT /product="PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC FT TRANSPORTER PSTC2" FT /note="Mb0952, pstC2, len: 324 aa. Equivalent to Rv0929, FT len: 324 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 324 aa overlap). pstC2, FT phosphate-transport integral membrane ABC transporter (see FT citations below), highly similar to others e.g. FT NP_302394.1|NC_002677 membrane-bound component of phosphate FT transport from Mycobacterium leprae (319 aa); FT CAB88474.1|AL353816 phosphate ABC transport system permease FT protein from Streptomyces coelicolor (336 aa); NP_290359.1| FT NC_002655 high-affinity phosphate-specific transport system FT (cytoplasmic membrane component) from Escherichia coli FT strain O157:H7 (319 aa); etc. Also similar to FT Rv935|MTCY08D9.04c|PSTC1 PROBABLE TRANSMEMBRANE ABC FT TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from FT Mycobacterium tuberculosis (338 aa). Contains FT binding-protein-dependent transport systems inner membrane FT component signature (PS00402)." FT /db_xref="GOA:P0A631" FT /db_xref="InterPro:IPR011864" FT /db_xref="UniProtKB/Swiss-Prot:P0A631" FT /protein_id="CAD93813.1" FT /translation="MVTEPLTKPALVAVDMRPARRGERLFKLAASAAGSTIVIAILLIA FT IFLLVRAVPSLRANHANFFTSTQFDTSDDEQLAFGVRDLFMVTALSSITALVLAVPVAV FT GIAVFLTHYAPRRLSRPFGAMVDLLAAVPSIIFGLWGIFVLAPKLEPIARFLNRNLGWL FT FLFKQGNVSLAGGGTIFTAGIVLSVMILPIVTSISREVFRQTPLIQIEAALALGATKWE FT VVRMTVLPYGRSGVVAASMLGLGRALGETVAVLVILRSAARPGTWSLFDGGYTFASKIA FT SAASEFSEPLPTGAYISAGFALFVLTFLVNAAARAIAGGKVNG" FT CDS 50464..51378 FT /transl_table=11 FT /gene="pstA1" FT /locus_tag="Mb0953" FT /product="PROBABLE PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE FT ABC TRANSPORTER PSTA1" FT /note="Mb0953, pstA1, len: 304 aa. Equivalent to Rv0930, FT len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 304 aa overlap). Probable pstA1, FT phosphate-transport integral membrane ABC transporter (see FT citation below), highly similar to others e.g. FT NP_302393.1|NC_002677 membrane-bound component of phosphate FT transport from Mycobacterium leprae (304 aa); FT CAB88473.1|AL353816 phosphate ABC transport system permease FT protein from Streptomyces coelicolor (354 aa) (N-terminus FT longer); NP_312689.1|NC_002695 phosphate transport system FT permease protein PstA from Escherichia coli strain O157:H7 FT (296 aa); etc. Also similar to Rv0936|MTCY08D9.03c|PSTA2 FT PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF FT PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis FT (301 aa)." FT /db_xref="GOA:Q7U103" FT /db_xref="InterPro:IPR005672" FT /db_xref="UniProtKB/TrEMBL:Q7U103" FT /protein_id="CAD93814.1" FT /translation="MSPSTSIEALDQPVKPVVFRPLTLRRRIKNSVATTFFFTSFVVAL FT IPLVWLLWVVIARGWFAVTRSGWWTHSLRGVLPEQFAGGVYHALYGTLVQAGVAAVLAV FT PLGLMTAVYLVEYGTGRMSRVTTFTVDVLAGVPSIVAALFVFSLWIATLGFQQSAFAVA FT LALVLLMLPVVVRAGEEMLRLVPDELREASYALGVPKWKTIVRIVAPIAMPGIVSGILL FT SIARVVGETAPVLVLVGYSHSINLDVFHGNMASLPLLIYTELTNPEHAGFLRVWGAALT FT LIIVVATINLAAAMIRFVATRRR" FT CDS complement(51385..52494) FT /transl_table=11 FT /gene="pknDb" FT /locus_tag="Mb0954c" FT /standard_name="mbk" FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D FT PKNDb [SECOND PART](PROTEIN KINASE D) (STPK D)" FT /EC_number="2.7.1.-" FT /note="Mb0954c, pknDb, len: 369 aa. Equivalent to 3' end of FT Rv0931c, len: 664 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 369 aa overlap). pknD FT (alternate gene name: mbk), transmembrane serine/threonine FT protein kinase (EC 2.7.1.-) (see citations below), FT equivalent to CAB62227.1|AJ250200 putative serine/threonine FT protein kinase from Mycobacterium bovis BCG (291 aa); and FT highly similar in N-terminus to P54744|PKNB_MYCLE probable FT serine/threonine-specific protein kinase (EC 2.7.1.-) from FT Mycobacterium leprae (622 aa). Also highly similar to FT others, particularly in N-terminal half e.g. FT NP_243370.1|NC_002570 serine/threonine protein kinase from FT Bacillus halodurans (664 aa); NP_268044.1|NC_002662 FT serine/threonine protein kinase from Lactococcus lactis FT (627 aa); etc. Also highly similar to other FT serine/threonine protein kinases from Mycobacterium FT tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, FT E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); FT pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase FT subdomain. Contains two transmembrane segments, which flank FT a highly repetitive region, suggesting a receptor-like FT anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN FT KINASES. Experimental studies show evidence of FT auto-phosphorylation on a serine residue. Appears to be FT co-transcribed with Rv0932c|pstS2. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, pknD exists as a single gene. In FT Mycobacterium bovis, a frameshift due to a single base FT insertion (*-t) splits pknD into 2 parts, pknDa and pknDb." FT /db_xref="GOA:Q7U102" FT /db_xref="InterPro:IPR013017" FT /db_xref="UniProtKB/TrEMBL:Q7U102" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93815.1" FT /translation="MLATPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSATVAGPLA FT ADSRGGNWPSQTGHSPAVPNALQASLGHAVPPAGNKRKVWAVVGAAAIVLVAIVAAAGY FT LVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGMYGRVVKLATGST FT GTTVLPFNGLYQPQGLAVDGAGTVYVTDFNNRVVTLAAGSNNQTVLPFDGLNYPEGLAV FT DTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYVTDTDNNRVV FT KLEAESNNQVVLPFTDITAPWGIAVDEAGTVYVTEHNTNQVVKLLAGSTTSTVLPFTGL FT NTPLAVAVDSDRTVYVADRGNDRVVKLTS" FT CDS complement(52505..53380) FT /transl_table=11 FT /gene="pknDa" FT /locus_tag="Mb0955c" FT /standard_name="mbk" FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE D FT PKNDa [FIRST PART] (PROTEIN KINASE D) (STPK D)" FT /EC_number="2.7.1.-" FT /note="Mb0955c, pknDa, len: 291 aa. Equivalent to 5' end of FT Rv0931c, len: 664 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100% identity in 276 aa overlap). pknD FT (alternate gene name: mbk), transmembrane serine/threonine FT protein kinase (EC 2.7.1.-) (see citations below), FT equivalent to CAB62227.1|AJ250200 putative serine/threonine FT protein kinase from Mycobacterium bovis BCG (291 aa); and FT highly similar in N-terminus to P54744|PKNB_MYCLE probable FT serine/threonine-specific protein kinase (EC 2.7.1.-) from FT Mycobacterium leprae (622 aa). Also highly similar to FT others, particularly in N-terminal half e.g. FT NP_243370.1|NC_002570 serine/threonine protein kinase from FT Bacillus halodurans (664 aa); NP_268044.1|NC_002662 FT serine/threonine protein kinase from Lactococcus lactis FT (627 aa); etc. Also highly similar to other FT serine/threonine protein kinases from Mycobacterium FT tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, FT E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); FT pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase FT subdomain. Contains two transmembrane segments, which flank FT a highly repetitive region, suggesting a receptor-like FT anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN FT KINASES. Experimental studies show evidence of FT auto-phosphorylation on a serine residue. Appears to be FT co-transcribed with Rv0932c|pstS2. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, pknD exists as a single gene. In FT Mycobacterium bovis, a frameshift due to a single base FT insertion (*-t) splits pknD into 2 parts, pknDa and pknDb." FT /db_xref="GOA:Q79IB8" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/TrEMBL:Q79IB8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93816.1" FT /translation="MSDAVPQVGSQFGPYQLLRLLGRGGMGEVYEAEDTRKHRVVALKL FT ISPQYSDNAVFRARMQREADTAGRLTEPHIVPIHDYGEINGQFFVEMRMIDGTSLRALL FT KQYGPLTPARAVAIVRQIAAALDAAHANGVTHRDVKPENILVTASDFAYLVDFGIARAA FT SDPGLTQTGTAVGTYNYMAPERFTGDEVTYRADIYALACVLGECLTGAPPYRADSVERL FT IAAHLMDPAPQPSQLRPGRVPPALDQVIAKGMAKNPAERFMSAGDLAIAAHDALNHIRA FT TPGHDDSAAR" FT CDS complement(53402..54514) FT /transl_table=11 FT /gene="pstS2" FT /locus_tag="Mb0956c" FT /product="PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS2 FT (PBP-2) (PSTS2)" FT /note="Mb0956c, pstS2, len: 370 aa. Equivalent to Rv0932c, FT len: 370 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 370 aa overlap). pstS2, FT phosphate-binding lipoprotein component of inorganic FT phosphate transport system (see citations below), highly FT similar to AAF74819.1|AF137360_1|AF137360 periplasmic FT phosphate permease from Mycobacterium avium (369 aa); FT Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC FT LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA FT scores: opt: 1601, E(): 0, (64.5% identity in 372 aa FT overlap); and Rv0934|MTCY08D9.05c|pstS1 PHOSPHATE-BINDING FT PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis FT (374 aa) (M. tuberculosis seems to have three PstS-like FT proteins, others being Rv0928 and Rv0934c). Also highly FT similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B FT PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA FT scores: opt: 460, E(): 2.7e-20, (31.2% identity in 375 aa FT overlap). Contains prokaryotic membrane lipoprotein lipid FT attachment site (PS00013) at N-terminus so the leader FT peptide of 22 aa is probably removed. BELONGS TO FAMILY OF FT PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN FT TRANSPORTERS. Appears to be co-transcribed with FT Rv0931c|pknD|mbk." FT /db_xref="GOA:Q7U101" FT /db_xref="InterPro:IPR005673" FT /db_xref="UniProtKB/TrEMBL:Q7U101" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93817.1" FT /translation="MKFARSGAAVSLLAAGTLVLTACGGGTNSSSSGAGGTSGSVHCGG FT KKELHSSGSTAQENAMEQFVYAYVRSCPGYTLDYNANGSGAGVTQFLNNETDFAGSDVP FT LNPSTGQPDRAAERCGSPAWDLPTVFGPIAITYNIKGVSTLNLDGPTTAKIFNGTITVW FT NDPQIQALNSGTDLPPTPISVIFRSDKSGTSDNFQKYLDGASNGAWGKGASETFNGGVG FT VGASGNNGTSALLQTTDGSITYNEWSFAVGKQLNMAQIITSAGPDPVAITTESVGKTIA FT GAKIMGQGNDLVLDTSSFYRPTQPGSYPIVLATYEIVCSKYPDATTGTAVRAFMQAAIG FT PGQEGLDQYGSIPLPKSFQAKLAAAVNAIS" FT CDS 54730..54945 FT /transl_table=11 FT /gene="pstBa" FT /locus_tag="Mb0957" FT /product="PHOSPHATE-TRANSPORT PROTEIN ABC TRANSPORTER PSTBa FT [FIRST PART]" FT /note="Mb0957, pstBa, len: 71 aa. Equivalent to the 5' end FT of Rv0933, len: 276 aa, from Mycobacterium tuberculosis FT strain H37Rv (98.4% identity in 64 aa overlap). pstB, FT phosphate-transport ATP-binding protein ABC transporter FT (see citations below), thermostable ATPase, highly similar FT to others e.g. NP_348334.1|NC_003030 ATPase component of FT ABC-type phosphate transport system from Clostridium FT acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate FT ABC transporter ATP-binding protein (pstB) from Borrelia FT burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC FT transporter (ATP-binding protein) from Bacillus subtilis FT (269 aa), FASTA scores: opt: 762, E(): 0, (47.7% identity FT in 243 aa overlap); etc. Also similar to other M. FT tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15 FT and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC FT transporters family signature, and PS00017 ATP/GTP-binding FT site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT FT PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium FT seem to have no influence on the functionality of this FT enzyme. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, pstB exists as a single gene. In FT Mycobacterium bovis, a frameshift due to a single base FT insertion (*-t) splits pstB into 2 parts, pstBa and pstBb." FT /db_xref="UniProtKB/TrEMBL:Q7U100" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93818.1" FT /translation="MACERLGGQSGAADVDAAAPAMAAVNLTLGFAGKTVLDQVSMGFP FT ARAVTSLMGPTGSGKTTFFAHPKPDE" FT CDS 54920..55561 FT /transl_table=11 FT /gene="pstBb" FT /locus_tag="Mb0958" FT /product="PHOSPHATE-TRANSPORT PROTEIN ABC TRANSPORTER PSTBb FT [SECOND PART]" FT /note="Mb0958, pstBb, len: 213 aa. Equivalent to the 3' end FT of Rv0933, len: 276 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 213 aa overlap). pstB, FT phosphate-transport ATP-binding protein ABC transporter FT (see citations below), thermostable ATPase, highly similar FT to others e.g. NP_348334.1|NC_003030 ATPase component of FT ABC-type phosphate transport system from Clostridium FT acetobutylicum (249 aa); NP_212352.1|NC_001318 phosphate FT ABC transporter ATP-binding protein (pstB) from Borrelia FT burgdorferi (260 aa); NP_390375.1|NC_000964 phosphate ABC FT transporter (ATP-binding protein) from Bacillus subtilis FT (269 aa), FASTA scores: opt: 762, E(): 0, (47.7% identity FT in 243 aa overlap); etc. Also similar to other M. FT tuberculosis ABC transporters e.g. MTCY253.24, E(): 2.5e-15 FT and MTCY359.14c, E(): 3.4e-15. Contains PS00211 ABC FT transporters family signature, and PS00017 ATP/GTP-binding FT site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT FT PROTEIN FAMILY (ABC TRANSPORTERS). Magnesium or calcium FT seem to have no influence on the functionality of this FT enzyme. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, pstB exists as a single gene. In FT Mycobacterium bovis, a frameshift due to a single base FT insertion (*-t) splits pstB into 2 parts, pstBa and pstBb." FT /db_xref="GOA:Q7U0Z9" FT /db_xref="InterPro:IPR005670" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0Z9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93819.1" FT /translation="MRTLNRMNDKVSGYRYSGDVLLGGRSIFNYRDVLEFRRRVGMLFQ FT RPNPFPMSIMDNVLAGVRAHKLVPRKEFRGVAQARLTEVGLWDAVKDRLSDSPFRLSGG FT QQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRLTVIIVTHNLAQAA FT RISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVAGLSGDVKDAKRGN" FT CDS 55582..56706 FT /transl_table=11 FT /gene="pstS1" FT /locus_tag="Mb0959" FT /standard_name="phoS1; phoS" FT /product="PERIPLASMIC PHOSPHATE-BINDING LIPOPROTEIN PSTS1 FT (PBP-1) (PSTS1)" FT /note="Mb0959, pstS1, len: 374 aa. Equivalent to Rv0934, FT len: 374 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 374 aa overlap). pstS1 (previously known FT as phoS1 or phoS), phosphate-binding lipoprotein component FT of inorganic phosphate transport system (see first, fourth, FT fifth and sixth citations below), highly similar to FT Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC FT LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA FT scores: opt: 460, E(): 5.9e-19, (31.2% identity in 375 aa FT overlap); and Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING FT PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis FT (374 aa), FASTA scores: opt: 435, E():1.1e-17, (30.0% FT identity in 380 aa overlap) (Mycobacterium tuberculosis FT seems to have three PstS-like proteins, others being FT Rv0932c and Rv0928c). Also highly similar to FT MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR FT from Mycobacterium tuberculosis (374 aa), FASTA scores: FT opt: 2459, E(): 0, (100% identity in 374 aa overlap). FT Contains a prokaryotic membrane lipoprotein lipid FT attachment site (PS00013) at the N-terminus so the 23 aa FT leader peptide sequence is probably removed. BELONGS TO FT FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE FT LIPOPROTEIN TRANSPORTERS." FT /db_xref="GOA:Q7U0Z8" FT /db_xref="HSSP:1IXH" FT /db_xref="InterPro:IPR005673" FT /db_xref="UniProtKB/TrEMBL:Q7U0Z8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93820.1" FT /translation="MKIRLHTLLAVLTAAPLLLAAAGCGSKPPSGSPETGAGAGTVATT FT PASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNIGA FT SDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKTWDD FT PQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVDFPAV FT PGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLPDAQSI FT QAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQAFLHWAI FT TDGNKASFLDQAHFQPLPPAVVKLSDALIATISS" FT CDS 56766..57782 FT /transl_table=11 FT /gene="pstC1" FT /locus_tag="Mb0960" FT /product="PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC FT TRANSPORTER PSTC1" FT /note="Mb0960, pstC1, len: 338 aa. Equivalent to Rv0935, FT len: 338 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 338 aa overlap). pstC1, FT phosphate-transport integral membrane ABC transporter (see FT citations below), highly similar to others e.g. FT NP_104768.1|NC_002678|pstC phosphate ABC transporter FT permease protein from Mesorhizobium loti (327 aa); FT NP_245372.1|NC_002663|PstC PstC protein from Pasteurella FT multocida (320 aa); P45191|PSTC_HAEIN PHOSPHATE TRANSPORT FT SYSTEM PERMEASE from Haemophilus influenza (315 aa), FASTA FT scores: opt: 667, E(): 0, (36.2% identity in 309 aa FT overlap); etc. Also similar to Rv0929|MTCY21C12.23|PSTC2 FT PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF FT PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis FT (324 aa), FASTA scores: opt: 487, E(): 4.1e-21, (32.3% FT identity in 303 aa overlap); and shows slight similarity to FT MTCY08D9.03c|PSTA2|Rv0936 PROBABLE TRANSMEMBRANE ABC FT TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from FT Mycobacterium tuberculosis (301 aa). Contains FT binding-protein-dependent transport systems inner membrane FT comp signature (PS00402)." FT /db_xref="GOA:P0A629" FT /db_xref="InterPro:IPR011864" FT /db_xref="UniProtKB/Swiss-Prot:P0A629" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93821.1" FT /translation="MLARAGEVGRAGPAIRWLGGIGAVIPLLALVLVLVVLVIEAMGAI FT RLNGLHFFTATEWNPGNTYGETVVTDGVAHPVGAYYGALPLIVGTLATSAIALIIAVPV FT SVGAALVIVERLPKRLAEAVGIVLELLAGIPSVVVGLWGAMTFGPFIAHHIAPVIAHNA FT PDVPVLNYLRGDPGNGEGMLVSGLVLAVMVVPIIATTTHDLFRQVPVLPREGAIALGMS FT NWECVRRVTLPWVSSGIVGAVVLGLGRALGETMAVAMVSGAVLGAMPANIYATMTTIAA FT TIVSQLDSAMTDSTNFAVKTLAEVGLVLMVITLLTNVAARGMVRRVSRTALPVGRGI" FT CDS 57784..58689 FT /transl_table=11 FT /gene="pstA2" FT /locus_tag="Mb0961" FT /product="PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC FT TRANSPORTER PSTA2" FT /note="Mb0961, pstA2, len: 301 aa. Equivalent to Rv0936, FT len: 301 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 301 aa overlap). pstA2, FT phosphate-transport integral membrane ABC transporter (see FT citations below), highly similar to others e.g. FT NP_442269.1|NC_000911|PstA phosphate transport system FT permease protein from Synechocystis sp. strain PCC 6803 FT (287 aa); NP_232473.1|NC_002506 phosphate ABC transporter FT permease protein from Vibrio cholerae (289 aa); FT P07654|PSTA_ECOLI PHOSPHATE TRANSPORT SYSTEM PERMEASE from FT Escherichia coli (296 aa), FASTA scores: opt: 464, E(): FT 6.7e-24, (30.5% identity in 282 aa overlap); etc. Also FT similar to O86345|MTCY21C12.24|PSTA1|Rv0930 PROBABLE FT TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE FT SYSTEM from Mycobacterium tuberculosis (304 aa), FASTA FT scores: opt: 369, E(): 6.1e-15, (32.7% identity in 248 aa FT overlap). Contains binding-protein-dependent transport FT systems inner membrane comp signature (PS00402)." FT /db_xref="GOA:P0A627" FT /db_xref="InterPro:IPR005672" FT /db_xref="UniProtKB/Swiss-Prot:P0A627" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93822.1" FT /translation="MGESAESGSRQLPAMSPPRRSVAYRRKIVDALWWAACVCCLAVVI FT TPTLWMLIGVVSRAVPVFHWSVLVQDSQGNGGGLRNAIIGTAVLAIGVILVGGTVSVLT FT GIYLSEFATGKTRSILRGAYEVLSGIPSIVLGYVGYLALVVYFDWGFSLAAGVLVLSVM FT SIPYIAKATESALAQVPTSYREAAEALGLPAGWALRKIVLKTAMPGIVTGMLVALALAI FT GETAPLLYTAGWSNSPPTGQLTDSPVGYLTYPIWTFYNQPSKSAQDLSYDAALLLIVFL FT LLLIFIGRLINWLSRRRWDV" FT CDS complement(58666..59487) FT /transl_table=11 FT /gene="Mb0962c" FT /locus_tag="Mb0962c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0962c, -, len: 273 aa. Equivalent to Rv0937c, len: FT 273 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 273 aa overlap). Conserved hypothetical FT protein, highly similar to others e.g. FT SC6G9.24c|T35620|AL079356 hypothetical protein from FT Streptomyces coelicolor (365 aa), FASTA scores: opt: 648, FT E(): 0, (36.5% identity in 274 aa overlap); FT Z99110|BSUB0007_223|NP_389224.1|NC_000964 hypothetical FT proteins from Bacillus subtilis (311 aa), FASTA scores: FT opt: 623, E(): 1.1e-31, (33.9% identity in 274 aa overlap); FT O28548|AE000984|AF1726|NP_070554.1|NC_000917 conserved FT hypothetical protein from Archaeoglobus fulgidus (286 aa), FT FASTA scores: opt: 583, E(): 0, (36.6% identity in 262 aa FT overlap); etc." FT /db_xref="GOA:Q7U0Z7" FT /db_xref="InterPro:IPR009187" FT /db_xref="UniProtKB/TrEMBL:Q7U0Z7" FT /protein_id="CAD93823.1" FT /translation="MRAIWTGSIAFGLVNVPVKVYSATADHDIRFHQVHAKDNGRIRYK FT RVCEACGEVVDYRDLARAYESGDGQMVAITDDDIASLPEERSREIEVLEFVPAADVDPM FT MFDRSYFLEPDSKSSKSYVLLAKTLAETDRMAIVHFTLRNKTRLAALRVKDFGKREVMM FT VHTLLWPDEIRDPDFPVLDQKVEIKPAELKMAGQVVDSMADDFNPDRYHDTYQEQLQEL FT IDTKLEGGQAFTAEDQPRLLDEPEDVSDLLAKLEASVKARSKANSNVPTPP" FT CDS 59603..61882 FT /transl_table=11 FT /gene="Mb0963" FT /locus_tag="Mb0963" FT /product="POSSIBLE ATP DEPENDANT DNA LIGASE (ATP DEPENDANT FT POLYDEOXYRIBONUCLEOTIDE SYNTHASE) (THERMOSTABLE DNA LIGASE) FT (ATP DEPENDANT POLYNUCLEOTIDE LIGASE) (SEALASE) (DNA REPAIR FT ENZYME) (DNA JOINASE)" FT /EC_number="6.5.1.1" FT /note="Mb0963, -, len: 759 aa. Equivalent to Rv0938, len: FT 759 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 759 aa overlap). Possible ATP-dependent FT DNA ligase (EC 6.5.1.1), with its C-terminus similar to FT N-terminal parts of many ATP-dependent DNA ligases e.g. FT NP_250828.1|NC_002516 probable ATP-dependent DNA ligase FT from Pseudomonas aeruginosa (840 aa); NP_105436.1|NC_002678 FT ATP-dependent DNA ligase from Mesorhizobium loti (829 aa); FT CAB92891.1|AL356932 probable ATP-dependent DNA ligase from FT Streptomyces coelicolor (326 aa); etc. The N-terminal half FT shows similarity with hypothetical proteins from FT Mycobacterium tuberculosis Rv0269c and Rv3730c; and the FT C-terminal half with the DNA ligases Rv3731 and Rv3062." FT /db_xref="GOA:P59971" FT /db_xref="InterPro:IPR014146" FT /db_xref="UniProtKB/Swiss-Prot:P59971" FT /protein_id="CAD93824.1" FT /translation="MGSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIA FT GRPATRKRWPNGVDQPAFFEKQLALSAPPWLSRATVAHRSGTTTYPIIDSATGLAWIAQ FT QAALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLLADI FT GLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAG FT KVFVDWSQNSGSKTTIAPYSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDG FT DLLERLDADAPVADRLTRYRRMRDASKTPEPIPTAKPVTGDGNTFVIQEHHARRPHYDF FT RLERDGVLVSWAVPKNLPDNTSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDS FT GTYDTEKFHDDPHTGEVIVNLHGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNL FT APMLATHGTVAGLKASQWAFEGKWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALA FT EDLADHHVVLDGEAVVLDSSGVPSFSQMQNRGRDTRVEFWAFDLLYLDGRALLGTRYQD FT RRKLLETLANATSLTVPELLPGDGAQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVK FT DKHWNTQEVVIGGWRAGEGGRSSGVGSLLMGIPGPGGLQFAGRVGTGLSERELANLKEM FT LAPLHTDESPFDVPLPARDAKGITYVKPALVAEVRYSEWTPEGRLRQSSWRGLRPDKKP FT SEVVRE" FT CDS 61879..63813 FT /transl_table=11 FT /gene="Mb0964" FT /locus_tag="Mb0964" FT /product="POSSIBLE BIFUNCTIONAL ENZYME: FT 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD FT ISOMERASE) + CYCLASE/DEHYDRASE" FT /EC_number="5.3.3.-" FT /note="Mb0964, -, len: 644 aa. Equivalent to Rv0939, len: FT 644 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 644 aa overlap). Possible bifunctional enzyme, FT including 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase FT activity (EC 5.3.3.-), and cyclase/dehydrase activity (EC FT undetermined). N-terminal part similar to many isomerases FT e.g. NP_343861.1|NC_002754 FT 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from FT Sulfolobus solfataricus (318 aa); NP_068932.1|NC_000917 FT 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from FT Archaeoglobus fulgidus (324 aa), FASTA scores: opt: 400, FT E(): 5.8e-15, (33.9% identity in 289 aa overlap); etc. And FT C-terminal part highly similar to many cyclases/dehydrases FT e.g. AAK61721.1|AY033994 cyclase-like protein from FT Streptomyces aureofaciens (305 aa); CAC44204.1|AL593842 FT cyclase from Streptomyces coelicolor (297 aa), FASTA FT scores: opt: 375, E(): 2.7e-26, (35.6% identity in 284 aa FT overlap); NP_343860.1|NC_002754 putative Cyclase/dehydrase FT from Sulfolobus solfataricus (308 aa); etc. Also similar to FT Rv2993c HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis." FT /db_xref="GOA:Q7U0Z6" FT /db_xref="InterPro:IPR002529" FT /db_xref="UniProtKB/TrEMBL:Q7U0Z6" FT /protein_id="CAD93825.1" FT /translation="MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTA FT GERAVRSPAAVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDTWYRI FT PAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGYTIF FT NDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIALVNGT FT VIGSGSTAQMDWSFGEVIAYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFPGWLHD FT GDVVTLQVEGLGETRQTVRTSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVA FT DRVWAWTLPDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDAL FT ITHSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLGPVATRYLRDR FT FGHFDFSGIKLRNADLTFDRDLAIELGGRRVDLLNLGPAHTTADSVVHVADAGVLFAGD FT LLFIGCTPIVWAGPIANWVAACDAMIALDAPTVVPGHGPVTGPDGIRAVRGYLAHIAEQ FT AEAAYRKGLSLPEAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQ FT AEWAARHCT" FT CDS complement(64060..64926) FT /transl_table=11 FT /gene="Mb0965c" FT /locus_tag="Mb0965c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0965c, -, len: 288 aa. Equivalent to Rv0940c, len: FT 288 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 288 aa overlap). Possible oxidoreductase (EC FT 1.-.-.-), similar to hypothetical proteins and FT oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 FT putative F420-dependent dehydrogenase from Rhodococcus FT erythropolis (295 aa); AAG52987.1|AF040570|Rif17 putative FT alkanal monooxygenase from Amycolatopsis mediterranei (356 FT aa); etc. Also similar to putative oxidoreductases from FT Mycobacterium tuberculosis such as FT Rv0953c|P71557|YT21_MYCTU (282 aa), FASTA scores: opt: 311, FT E(): 3.7e-08, (31.0% identity in 248 aa overlap), Rv3079c FT (275 aa), Rv0791c (347 aa), etc." FT /db_xref="InterPro:IPR016048" FT /db_xref="UniProtKB/Swiss-Prot:P64762" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93826.1" FT /translation="MRFSYAEAMTDFTFYIPLAKAAEAAGYSSMTIPDSIAYPFESDSK FT YPYTPDGNREFMDGKPFIETFVLTAALGAVTTRLRFNFFVLKLPIRPPALVAKQAGSLA FT ALIGNRVGLGVGTSPWPEDYELMGVPFAKRGKRIDECIEIVRGLTTGDYFEFHGEFYDI FT PKTKMTPAPTQPIPILVGGHADAALRRAARADGWMHGGGDPDELDRLIARVKRLREEAG FT KTSPFEIHVISLDGFTVDGVKRLEDKGVTDVIVGFRVPYTMGPDTEPLQTKIRNLEMFA FT ENVIAKV" FT CDS complement(65011..65784) FT /transl_table=11 FT /gene="Mb0966c" FT /locus_tag="Mb0966c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0966c, -, len: 257 aa. Equivalent to Rv0941c, len: FT 257 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 257 aa overlap). Conserved hypothetical FT protein, showing some similarity with parts of several FT hypothetical proteins from Streptomyces coelicolor e.g. FT AL035161|SC9C7_20 (860 aa), FASTA scores: opt: 197, E(): FT 2.6e-05, (34.2% identity in 114 aa overlap)." FT /db_xref="InterPro:IPR002645" FT /db_xref="UniProtKB/TrEMBL:Q7U0Z5" FT /protein_id="CAD93827.1" FT /translation="MVAVSTAAKSPTALAIAVRTQDSVVILTADGALDSSSSALLRDSL FT TRATLEQPSAVIVNVTELQVAEESAWSVFISARWQADFRADVPVLLVCGHRAGRAAVTR FT TGVARFMPVYPTEKAASKAIGRLARRNFKRSDAQLPANLNSLRESRQLVREWLTQWSRP FT GLIPVALVVVNVFVENVLKHTGSDPVMRIESDGPTATIAVSDGSSAPAVRLASPPKGID FT VSGLAIVAALSRAWGSSPTSSGKTVWAIIGPENQL" FT CDS 65827..66105 FT /transl_table=11 FT /gene="Mb0967" FT /locus_tag="Mb0967" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0967, -, len: 92 aa. Equivalent to Rv0942, len: 92 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 92 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/Swiss-Prot:P64764" FT /protein_id="CAD93828.1" FT /translation="MGRSATIAMVPKRRDAMNRHSGPILSSGFIASSSNSCPANSLRMP FT SALAAETLSFDDRAVRRSTHHPGGGYPQKHAINLQSGLCPAYANASR" FT CDS complement(66163..67203) FT /transl_table=11 FT /gene="Mb0968c" FT /locus_tag="Mb0968c" FT /product="PROBABLE MONOOXYGENASE" FT /EC_number="1.-.-.-" FT /note="Mb0968c, -, len: 346 aa. Equivalent to Rv0943c, len: FT 346 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 346 aa overlap). Possible monooxygenase (EC FT 1.-.-.-), similar in part to others e.g. FT NP_250229.1|NC_002516 probable flavin-containing FT monooxygenase from Pseudomonas aeruginosa (527 aa); FT AAC36351.1|AF090329 cyclohexanone monooxygenase homolog FT from Pseudomonas fluorescens (437 aa); CAB59668.1|AL132674 FT monooxygenase from Streptomyces coelicolor (519 aa); etc. FT Also similar to putative monooxygenases from Mycobacterium FT tuberculosis e.g. Rv1393c|P71662|CY21B4.10C (492 aa). FASTA FT scores: opt: 129, E(): 8.5e-21, (27.5% identity in 236 aa FT overlap); Rv0892 (495 aa); Rv3049c (524 aa); etc." FT /db_xref="UniProtKB/Swiss-Prot:P64766" FT /protein_id="CAD93829.1" FT /translation="MAGVSEAERRGHRKLVRFQARRAIGPIRPTSAAWDRDFDPAGKRI FT AVVGTDAAAAHYISRLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHPAV FT AWATAAIDALTSSGIRTSDGVEHPVDAIIYGTGFAIADQVGDQTLVGAGGVTIRQAWDD FT GMEPYLGVAVHGFPNYFFITGPDTAAQARCVVECMKLMERTASRRIEVRRSSQQVFNER FT AQLKPAQPHRQTGGLEAFDLSSAATEDDQTYDGAATLTLAGARFRVRVRLTGHLDPIDG FT NYHWQGTVFDSLPETSLTHARAATLTIGGRSAPARITEQTPWGTHSVAGVGPPPYARSG FT PASATT" FT CDS 67232..67708 FT /transl_table=11 FT /gene="Mb0969" FT /locus_tag="Mb0969" FT /product="POSSIBLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE FT (FAPY-DNA GLYCOSYLASE)" FT /EC_number="3.2.2.23" FT /note="Mb0969, -, len: 158 aa. Equivalent to Rv0944, len: FT 158 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 158 aa overlap). Possible FT formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), similar FT to C-terminus of formamidopyrimidine-DNA glycosylases e.g. FT CAB63194.1|AL133469 putative formamidopyrimidine-DNA FT glycosylase from Streptomyces coelicolor (287 aa); FT FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA FT glycosylase (EC 3.2.2.23) from Lactococcus lactis subsp. FT lactis (273 aa), FASTA scores: opt: 246, E(): 2.4e-09, FT (28.9% identity in 142 aa overlap); FT O50606|FPG_THETH|MUTM|FPG FORMAMIDOPYRIMIDINE-DNA FT GLYCOSYLASE from Thermus thermophilus (267 aa); etc. Also FT similar to C-termini of endonucleases or DNA glycosylases FT of Mycobacterium tuberculosis e.g. Rv3297, Rv2464c, FT Rv2924c. MAY BE BELONG TO THE FPG FAMILY." FT /db_xref="GOA:Q7U0Z4" FT /db_xref="HSSP:1EE8" FT /db_xref="InterPro:IPR015886" FT /db_xref="UniProtKB/TrEMBL:Q7U0Z4" FT /protein_id="CAD93830.1" FT /translation="MAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAG FT IGNAYSDEILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKGEK FT RSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK" FT CDS 67714..68475 FT /transl_table=11 FT /gene="Mb0970" FT /locus_tag="Mb0970" FT /product="PUTATIVE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0970, -, len: 253 aa. Equivalent to Rv0945, len: FT 253 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 253 aa overlap). Probable short-chain FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT dehydrogenases/reductases e.g. NP_346338.1|NC_003028 FT oxidoreductase (short chain dehydrogenase/reductase family) FT from Streptococcus pneumoniae (253 aa); FT AAB70845.1|AF019986|PksB from Dictyostelium discoideum (260 FT aa); AAF86624.1|U87786 clavaldehyde dehydrogenase from FT Streptomyces clavuligerus (247 aa); P37440|UCPA_ECOLI FT oxidoreductase from Escherichia coli (285 aa), FASTA FT scores: opt: 275, E(): 1.1e-12, (33.8% identity in 201 aa FT overlap); etc. Contains PS00061 Short-chain FT dehydrogenases/reductases family signature. BELONGS TO THE FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7U0Z3" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U0Z3" FT /protein_id="CAD93831.1" FT /translation="MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRLT FT ELKAELSQRYPDIKIAVAELDVNDHERVPKVFAELSDEIGGIDRVIVNAGIGKGARLGS FT GKLWANKATIETNLVAALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYAASK FT AGVRSLGESLRAEYAQGPIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVAAIER FT EPGRAAVPWWPWAPLVRLMWVLPPRLTRRFA" FT CDS complement(68491..70152) FT /transl_table=11 FT /gene="pgi" FT /locus_tag="Mb0971c" FT /product="PROBABLE GLUCOSE-6-PHOSPHATE ISOMERASE PGI (GPI) FT (PHOSPHOGLUCOSE ISOMERASE) (PHOSPHOHEXOSE ISOMERASE) (PHI)" FT /EC_number="5.3.1.9" FT /note="Mb0971c, pgi, len: 553 aa. Equivalent to Rv0946c, FT len: 553 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 553 aa overlap). Probable pgi, FT glucose-6-phosphate isomerase (EC 5.3.1.9), equivalent to FT NP_301236.1|NC_002677 glucose-6-phosphate isomerase from FT Mycobacterium leprae (554 aa); and P96803|G6PI_MYCSM FT GLUCOSE-6-PHOSPHATE ISOMERASE from Mycobacterium smegmatis FT (442 aa). Also highly similar to others e.g. T36015 FT glucose-6-phosphate isomerase from Streptomyces coelicolor FT (551 aa); P11537|G6PI_ECOLI|GPI glucose-6-phosphate FT isomerase from Escherichia coli strains K12 and O157:H7 FT (549 aa), FASTA scores: opt: 1779, E(): 0, (51.4% identity FT in 554 aa overlap); etc. Contains PS00765 Phosphoglucose FT isomerase signature 1, and PS00174 Phosphoglucose isomerase FT signature 2. BELONGS TO THE GPI FAMILY." FT /db_xref="GOA:P64193" FT /db_xref="HSSP:1HM5" FT /db_xref="InterPro:IPR018189" FT /db_xref="UniProtKB/Swiss-Prot:P64193" FT /protein_id="CAD93832.1" FT /translation="MTSAPIPDITATPAWDALRRHHDQIGNTHLRQFFADDPGRGRELT FT VSVGDLYIDYSKHRVTRETLALLIDLARTAHLEERRDQMFAGVHINTSEDRAVLHTALR FT LPRDAELVVDGQDVVTDVHAVLDAMGAFTDRLRSGEWTGATGKRISTVVNIGIGGSDLG FT PVMVYQALRHYADAGISARFVSNVDPADLIATLADLDPATTLFIVASKTFSTLETLTNA FT TAARRWLTDALGDAAVSRHFVAVSTNKRLVDDFGINTDNMFGFWDWVGGRYSVDSAIGL FT SLMTVIGRDAFADFLAGFHIIDRHFATAPLESNAPVLLGLIGLWYSNFFGAQSRTVLPY FT SNDLSRFPAYLQQLTMESNGKSTRADGSPVSADTGEIFWGEPGTNGQHAFYQLLHQGTR FT LVPADFIGFAQPLDDLPTAEGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAADGTPAHVV FT AHKVMPGNRPSTSILASRLTPSVLGQLIALYEHQVFTEGVVWGIDSFDQWGVELGKTQA FT KALLPVITGAGSPPPQSDSSTDGLVRRYRTERGRAG" FT CDS complement(70767..70997) FT /transl_table=11 FT /gene="Mb0972c" FT /locus_tag="Mb0972c" FT /product="PROBABLE MYCOLYL TRANSFERASE" FT /EC_number="2.-.-.-" FT /note="Mb0972c, -, len: 76 aa. Equivalent to Rv0947c, len: FT 76 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 76 aa overlap). Probable mycolyl transferase FT pseudogene (EC 2.-.-.-), similar to part of FT P31953|A85C_MYCTU|fbpC2 antigen 85-c precursor (85c) FT (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium FT tuberculosis (340 aa), FASTA scores: opt: 213, E(): 2e-08, FT (69.6% identity in 46 aa overlap)." FT /db_xref="GOA:Q7TVC2" FT /db_xref="HSSP:1DQZ" FT /db_xref="UniProtKB/TrEMBL:Q7TVC2" FT /protein_id="CAD93833.1" FT /translation="MGGSFDRAARARRQLDNLVNVVAAGSTHRLMVPSRSMHRLIKVEF FT QGGGPHAWYLSDGILARDDYNGRDIHLPVFG" FT CDS complement(71113..71430) FT /transl_table=11 FT /gene="Mb0973c" FT /locus_tag="Mb0973c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0973c, -, len: 105 aa. Equivalent to Rv0948c, len: FT 105 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 105 aa overlap). Conserved hypothetical FT protein, equivalent to NP_301237.1|NC_002677 conserved FT hypothetical protein from Mycobacterium leprae (105 aa). FT Also similar (except in N-terminus) to FT SCD63.16c|CAB82023.1|AL161755 hypothetical protein from FT Streptomyces coelicolor (110 aa); and to N-terminus of two FT chorismate mutase/prephenate dehydratase." FT /db_xref="GOA:P64768" FT /db_xref="InterPro:IPR010958" FT /db_xref="UniProtKB/Swiss-Prot:P64768" FT /protein_id="CAD93834.1" FT /translation="MRPEPPHHENAELAAMNLEMLESQPVPEIDTLREEIDRLDAEILA FT LVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLG FT H" FT CDS 71727..74042 FT /transl_table=11 FT /gene="uvrD1" FT /locus_tag="Mb0974" FT /product="PROBABLE ATP DEPENDENT DNA HELICASE UVRD1" FT /EC_number="3.6.1.-" FT /note="Mb0974, uvrD1, len: 771 aa. Equivalent to Rv0949, FT len: 771 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 771 aa overlap). Probable uvrD1, ATP FT dependent DNA helicase (EC 3.6.1.-), equivalent to FT P_301239.1|NC_002677 putative ATP-dependent DNA helicase FT from Mycobacterium leprae (778 aa). Also highly similar to FT others e.g. CAB92660.1|AL356832 from Streptomyces FT coelicolor (831 aa) (N-terminus longer); P56255|PCRA_BACST FT from Bacillus stearothermophilus (724 aa); FT Q10213|YAY5_SCHPO from Schizosaccharomyces pombe (Fission FT yeast) (887 aa), FASTA scores: opt: 927, E(): 0, (33.5% FT identity in 659 aa overlap); etc. Also similar to several FT other UvrD-like proteins in Mycobacterium tuberculosis e.g. FT Rv3201c, Rv3198c, Rv3202c. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF FT HELICASES. Note that previously known as uvrD." FT /db_xref="GOA:P0A5A4" FT /db_xref="HSSP:1PJR" FT /db_xref="InterPro:IPR014016" FT /db_xref="UniProtKB/Swiss-Prot:P0A5A4" FT /protein_id="CAD93835.1" FT /translation="MSVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGAG FT SGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAAEMRERVVGLVGEKARYMWVSTFH FT STCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAISNL FT KNELIDPHQALAGLTEDSDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVLQAFP FT QIAQYYRRRFRHVLVDEYQDTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQSIYAF FT RGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSVIARNAGRREKRLWTDAGAG FT ELIVGYVADNEHDEARFVAEEIDALAEGSEITYNDVAVFYRTNNSSRSLEEVLIRAGIP FT YKVVGGVRFYERKEIRDIVAYLRVLDNPGDAVSLRRILNTPRRGIGDRAEACVAVYAEN FT TGVGFGDALVAAAQGKVPMLNTRAEKAIAGFVEMFDELRGRLDDDLGELVEAVLERTGY FT RRELEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGPDDEDVPDTGVLADFLERV FT SLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRALDNPTELSEER FT RLAYVGITRARQRLYVSRAIVRSSWGQPMLNPESRFLREIPQELIDWRRTAPKPSFSAP FT VSGAGRFGSARPSPTRSGASRRPLLVLQVGDRVTHDKYGLGRVEEVSGVGESAMSLIDF FT GSSGRVKLMHNHAPVTKL" FT CDS complement(74123..75121) FT /transl_table=11 FT /gene="Mb0975c" FT /locus_tag="Mb0975c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0975c, -, len: 332 aa. Equivalent to Rv0950c, len: FT 332 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 332 aa overlap). Conserved hypothetical FT protein, highly similar to AL035500|MLCL373.02c|T45433 FT hypothetical protein from Mycobacterium leprae (343 aa), FT FASTA scores: opt: 1500, E(): 0, (71.0% identity in 331 aa FT overlap). C-terminus highly similar to part of various FT proteins e.g. C-terminal part of NP_441943.1|NC_000911|NlpD FT lipoprotein from Synechocystis sp (715 aa); N-terminal part FT of NP_066789.1|NC_002576 putative peptidase from FT Rhodococcus equi (546 aa); C-terminal part of FT NP_212396.1|NC_001318 conserved hypothetical protein from FT Borrelia burgdorferi (417 aa); C-terminal part of FT P33648|NLPD_ECOLI|nlpd lipoprotein from Escherichia coli FT (379 aa), FASTA scores: opt: 276, E(): 2e-10, (29.9% FT identity in 234 aa overlap); etc." FT /db_xref="GOA:Q7U0Z2" FT /db_xref="InterPro:IPR016047" FT /db_xref="UniProtKB/TrEMBL:Q7U0Z2" FT /protein_id="CAD93836.1" FT /translation="MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELDD FT LDLGDDCVFDYEAQLLAAPELDDLDDADDLAPEWLVAPTVVLTPEVTPVSRRVGQHRKQ FT PIGAARGRLLISAMAAGAAAAAAHTAIQQSETPRTETVLTAHASALNEGSGSNPPRGVQ FT VIAAQPAASAAVHNAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLH FT AGIDLANAIGTPIYAVSDGVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLVSVGER FT VMAGDQIATMGSRGFSTGPHLHFEVLLGGTERVDPVPWLAKRGLSVGNYTG" FT CDS 75431..76594 FT /transl_table=11 FT /gene="sucC" FT /locus_tag="Mb0976" FT /product="PROBABLE SUCCINYL-COA SYNTHETASE (BETA CHAIN) FT SUCC (SCS-BETA)" FT /EC_number="6.2.1.5" FT /note="Mb0976, sucC, len: 387 aa. Equivalent to Rv0951, FT len: 387 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 387 aa overlap). Probable sucC, FT succinyl-Coa synthetase, beta chain (EC 6.2.1.5), FT equivalent to AL035500|MLCL373_3|NP_301241.1|NC_002677 FT succinyl-CoA synthase [beta] chain from Mycobacterium FT leprae (393 aa), FASTA score: (86.7% identity in 391 aa FT overlap). Also highly similar to others e.g. FT AB92671.1|AL356832 succinyl-CoA synthetase beta chain from FT Streptomyces coelicolor (394 aa); P25126|SUCC_THEFL FT SUCCINYL-COA SYNTHETASE BETA CHAIN from Thermus aquaticus FT (378 aa); P07460|SUCC_ECOLI succinyl-CoA synthetase beta FT chain from Escherichia coli (388 aa), FASTA scores: opt: FT 933, E(): 0, (41.0% identity in 390 aa overlap); etc." FT /db_xref="GOA:Q7U0Z1" FT /db_xref="HSSP:1JKJ" FT /db_xref="InterPro:IPR016102" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0Z1" FT /protein_id="CAD93837.1" FT /translation="MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVK FT AQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEYYLSF FT LLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGHLPA FT EVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHA FT EFEDRAATDPLELKAKEHDLNYVKLDGQVGIIGNGAGLAMSTLDVVAYAGEKHGGVKPA FT NFLDIGGGASAEVMAAGLDVVLGDQQVKSVFVNVFGGITSCDAVATGIVKALGMLGDEA FT NKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA" FT CDS 76607..77518 FT /transl_table=11 FT /gene="sucD" FT /locus_tag="Mb0977" FT /product="PROBABLE SUCCINYL-COA SYNTHETASE (ALPHA CHAIN) FT SUCD (SCS-ALPHA)" FT /EC_number="6.2.1.5" FT /note="Mb0977, sucD, len: 303 aa. Equivalent to Rv0952, FT len: 303 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 303 aa overlap). Probable sucD, FT succinyl-CoA synthetase, alpha chain (EC 6.2.1.5), FT equivalent to AL035500|MLCL373_4|NP_301242.1|NC_002677 FT succinyl-CoA synthase [alpha] chain from Mycobacterium FT leprae (300 aa), FASTA score: (86.3% identity in 300 aa FT overlap). Also highly similar to others e.g. FT CAB92672.1|AL356832 from Streptomyces coelicolor (294 aa); FT P53591|SUCD_COXBU from Escherichia coli (288 aa), FASTA FT scores: opt: 855, E(): 0, (53.8% identity in 286 aa FT overlap); etc. Contains PS00399 ATP-citrate lyase and FT succinyl-CoA ligases active site, and PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7U0Z0" FT /db_xref="HSSP:1JKJ" FT /db_xref="InterPro:IPR016102" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0Z0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93838.1" FT /translation="MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNAR FT KAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPL FT LVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIG FT LVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKLIVMIGEI FT GGDAEERAADFIKTNVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAA FT GVKVGKTPSATAALAREILLSL" FT CDS complement(77553..78401) FT /transl_table=11 FT /gene="Mb0978c" FT /locus_tag="Mb0978c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0978c, -, len: 282 aa. Equivalent to Rv0953c, len: FT 282 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 282 aa overlap). Possible oxidoreductase (EC FT 1.-.-.-), equivalent to CAA48222.1|X68102 hypothetical FT protein from Mycobacterium avium subsp. paratuberculosis FT (166 aa). Similar to several hypothetical proteins and FT oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 FT putative F420-dependent dehydrogenase from Rhodococcus FT erythropolis (295 aa); NP_070025.1|NC_000917 FT N5,N10-methylenetetrahydromethanopterin reductase (mer-2) FT from Archaeoglobus fulgidus (348 aa); etc. Also similar to FT several hypothetical proteins and oxidoreductases from FT Mycobacterium tuberculosis e.g. FT Rv2161c|O06216|Z95388|MTCY270.07 (288 aa), FASTA scores: FT opt: 633, E(): 0, (40.4% identity in 277 aa overlap), FT Rv3079c (275 aa), Rv0791c (347 aa), etc. Contains PS00201 FT Flavodoxin signature." FT /db_xref="InterPro:IPR016048" FT /db_xref="UniProtKB/Swiss-Prot:P64770" FT /protein_id="CAD93839.1" FT /translation="MHYGLVLFTSDRGITPAAAARLAESHGFRTFYVPEHTHIPVKRQA FT AHPTTGDASLPDDRYMRTLDPWVSLGAASAVTSRIRLATAVALPVEHDPITLAKSIATL FT DHLSHGRVSVGVGFGWNTDELVDHGVPPGRRRTMLREYLEAMRALWTQEEACYDGEFVK FT FGPSWAWPKPVQPHIPVLVGAAGTEKNFKWIARSADGWITTPRDVDIDEPVKLLQDIWA FT AAGRDGLPQIVALDVKPVPDKLARWAELGVTEVLFGMPDRSADDAAAYVERLAAKLACC FT V" FT CDS 78566..79477 FT /transl_table=11 FT /gene="Mb0979" FT /locus_tag="Mb0979" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0979, -, len: 303 aa. Equivalent to Rv0954, len: FT 303 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 303 aa overlap). Probable conserved FT transmembrane protein, highly similar to 34KD_MYCPA|Q04959 FT 34 kd antigenic protein from Mycobacterium paratuberculosis FT (298 aa), FASTA scores: opt: 1023, E(): 7.2e-36, (59.3% FT identity in 305 aa overlap); AAC69251.1|U82111 34 kDa FT antigen precursor from Mycobacterium leprae (336 aa); and FT AL035500|MLCL373.06 hypothetical membrane protein from FT Mycobacterium leprae (297 aa), FASTA score: (55.6% identity FT in 315 aa overlap)." FT /db_xref="GOA:P65638" FT /db_xref="UniProtKB/Swiss-Prot:P65638" FT /protein_id="CAD93840.1" FT /translation="MTYSPGNPGYPQAQPAGSYGGVTPSFAHADEGASKLPMYLNIAVA FT VLGLAAYFASFGPMFTLSTELGGGDGAVSGDTGLPVGVALLAALLAGVALVPKAKSHVT FT VVAVLGVLGVFLMVSATFNKPSAYSTGWALWVVLAFIVFQAVAAVLALLVETGAITAPA FT PRPKFDPYGQYGRYGQYGQYGVQPGGYYGQQGAQQAAGLQSPGPQQSPQPPGYGSQYGG FT YSSSPSQSGSGYTAQPPAQPPAQSGSQQSHQGPSTPPTGFPSFSPPPPVSAGTGSQAGS FT APVNYSNPSGGEQSSSPGGAPV" FT CDS 79517..80884 FT /transl_table=11 FT /gene="Mb0980" FT /locus_tag="Mb0980" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0980, -, len: 455 aa. Equivalent to Rv0955, len: FT 455 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 455 aa overlap). Probable conserved integral FT membrane protein, highly similar to AL035500|MLCL373_6 FT putative membrane protein from Mycobacterium leprae (430 FT aa), FASTA score: (75.9% identity in 419 aa overlap); and FT AAL05878.1|AF411607_2|AF411607 unknown protein from FT Mycobacterium avium subsp. paratuberculosis (409 aa)." FT /db_xref="GOA:P64772" FT /db_xref="UniProtKB/Swiss-Prot:P64772" FT /protein_id="CAD93841.1" FT /translation="MNRVSASADDRAAGARPARDLVRVAFGPGVVALGIIAAVTLLQLL FT IANSDMTGAWGAIASMWLGVHLVPISIGGRALGVMPLLPVLLMVWATARSTARATSPQS FT SGLVVRWVVASALGGPLLMAAIALAVIHDASSVVTELQTPSALRAFTSVLVVHSVGAAT FT GVWSRVGRRALAATALPDWLHDSMRAAAAGVLALLGLSGVVTAGSLVVHWATMQELYGI FT TDSIFGQFSLTVLSVLYAPNVIVGTSAIAVGSSAHIGFATFSSFAVLGGDIPALPILAA FT APTPPLGPAWVALLIVGASSGVAVGQQCARRALPFVAAMAKLLVAAVAGALVMAVLGYG FT GGGRLGNFGDVGVDEGALVLGVLFWFTFVGWVTVVIAGGISRRPKRLRPAPPVELDADE FT SSPPVDMFDGAASEQPPASVAEDVPPSHDDIANGLKAPTADDEALPLSDEPPPRAD" FT CDS 81000..81647 FT /transl_table=11 FT /gene="purN" FT /locus_tag="Mb0981" FT /product="PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FT FORMYLTRANSFERASE PURN (GART) (GAR TRANSFORMYLASE) FT (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE)" FT /EC_number="2.1.2.2" FT /note="Mb0981, purN, len: 215 aa. Equivalent to Rv0956, FT len: 215 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 215 aa overlap). Probable purN, FT 5'-phosphoribosylglycinamide formyltransferase (EC FT 2.1.2.2), equivalent to AAF05726.1|AF191543_1|AF191543|PurN FT phosphoribosylglycinamide formyltransferase from FT Mycobacterium avium subsp. paratuberculosis (209 aa); and FT AL035500|MLCL373_7 from Mycobacterium leprae (215 aa), FT FASTA score: (79.4% identity in 214 aa overlap). Also FT highly similar to others e.g. BAA89443.1|AB003159 from FT Corynebacterium ammoniagenes (199 aa); FT NP_241498.1|NC_002570 from Bacillus halodurans (188 aa); FT P08179|PUR3_ECOLI|B2500 from Escherichia coli strain K12 FT (212 aa), FASTA scores: opt: 380, E(): 2.4e-18, (36.6% FT identity in 183 aa overlap); C-terminus of FT P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN FT ADENOSINE-3 from Drosophila pseudoobscura (Fruit fly) (1364 FT aa); etc." FT /db_xref="GOA:Q7U0Y9" FT /db_xref="HSSP:1GAR" FT /db_xref="InterPro:IPR004607" FT /db_xref="UniProtKB/TrEMBL:Q7U0Y9" FT /protein_id="CAD93842.1" FT /translation="MQEPLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAVG FT VDRECRAAEIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRILGP FT QFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILAQQP FT VPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRTATMGRKVTIG" FT CDS 81644..83215 FT /transl_table=11 FT /gene="purH" FT /locus_tag="Mb0982" FT /product="PROBABLE BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN FT PURH: PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FT FORMYLTRANSFERASE (AICAR TRANSFORMYLASE) FT (5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE-4-CARBOXAMIDE FT FORMYLTRANSFERASE) + INOSINEMONOPHOSPHATE CYCLOHYDROLASE FT (IMP CYCLOHYDROLASE) (INOSINICASE) (IMP SYNTHETASE) (ATIC)" FT /EC_number="2.1.2.3" FT /EC_number="3.5.4.10" FT /note="Mb0982, purH, len: 523 aa. Equivalent to Rv0957, FT len: 523 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 523 aa overlap). Probable purH, FT bifunctional purine biosynthesis protein including FT 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide FT formyltransferase (EC 2.1.2.3) and inosine-monophosphate FT (IMP) cyclohydrolase (EC 3.5.4.10), equivalent to FT AL035500|MLCL373_8 putative FT phosphoribosylaminoimidazolecarboxamide formyltransferase FT from Mycobacterium leprae (527 aa), FASTA score: (88.1% FT identity in 520 aa overlap); and FT AF05727.1|AF191543_2|AF191543|PurH from Mycobacterium avium FT subsp. paratuberculosis (527 aa). Also highly similar to FT others e.g. CAB92677.1|AL356832 bifunctional purine FT biosynthesis protein from Streptomyces coelicolor (523 aa); FT NP_388534.1|NC_000964 phosphoribosylaminoimidazole carboxy FT formyl formyltransferase + inosine-monophosphate FT cyclohydrolase from Bacillus subtilis (512 aa); FT P15639|PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide FT formyltransferase from Escherichia coli (529 aa), FASTA FT scores: opt: 1147, E(): 0, (44.8% identity in 533 aa FT overlap); etc. BELONGS TO THE PURH FAMILY." FT /db_xref="GOA:P67542" FT /db_xref="HSSP:1G8M" FT /db_xref="InterPro:IPR011607" FT /db_xref="UniProtKB/Swiss-Prot:P67542" FT /protein_id="CAD93843.1" FT /translation="MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAK FT TIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFE FT LVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAA FT LRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAM FT LRYGENPHQQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAI FT IKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIV FT APGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWT FT LATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERG FT GERVRGAVAASDAFFPFPDGLETLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTG FT ARHFAH" FT CDS 83322..84701 FT /transl_table=11 FT /gene="Mb0983" FT /locus_tag="Mb0983" FT /product="POSSIBLE MAGNESIUM CHELATASE" FT /EC_number="4.99.1.-" FT /note="Mb0983, -, len: 459 aa. Equivalent to Rv0958, len: FT 459 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 459 aa overlap). Possible magnesium FT chelatase (EC 4.99.1.-), similar to others (especially in FT N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 FT putative magnesium protoporphyrin chelatase from FT Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148, FT E(): 0, (42.4% identity in 450 aa overlap); FT Q44498|CHLI_ANAVA MAGNESIUM-CHELATASE SUBUNIT CHLI from FT Anabaena variabilis (338 aa); T31460 probable magnesium FT chelatase (EC 4.99.1.-) chain I bchI from Heliobacillus FT mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop)" FT /db_xref="GOA:Q7U0Y8" FT /db_xref="UniProtKB/TrEMBL:Q7U0Y8" FT /protein_id="CAD93844.1" FT /translation="MSPSNLPRTVGELRAAGHRERGVKQEIRENLLTALADGDNVWPGI FT LGFDDTVIPQVERALIAGHDFVLLGERGQGKTRLLRALAGLLDEWTPVIAGAELGEHPY FT TPITPESIRRAAQLGDDLPVAWKHRSERYTEKLATPDTSVADLVGDVDPIKVAEGRSLG FT DPETIAYGLIPRAHRGIVAVNELPDLAERIQVSMLNVMEERDIQVRGYTLRLPLDVLVV FT ASANPEDYTNRGRIITPIKDRFGAEIRTHYPLELEAEMGVIVQEAHLSAQVPDYLMQVL FT ARFARYLRESRSIDQRSGVSARFAIAAAETVAAAARHRGAVLGETDPVARVVDLGTVID FT VLRGKLEFESGEEGREQAVLEHLLRRATADTASRVLGGIDVGSLVTAVEGGSAVTTGER FT VSAKDVLAAVPGLPVVDRIARKLGAESEGERAAALELALEALYLAKRVDKVCGEGQTVY FT G" FT CDS 84694..86712 FT /transl_table=11 FT /gene="Mb0984" FT /locus_tag="Mb0984" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0984, -, len: 672 aa. Equivalent to Rv0959, len: FT 672 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 672 aa overlap). Conserved hypothetical FT protein, similar to AE002069|AE002069_12 hypothetical FT protein from Deinococcus radiodurans (403 aa), FASTA FT scores: opt: 395, E(): 1.3e-15, (26.8% identity in 426 aa FT overlap). Contains a single copy at the N-terminus of a FT short repeat found three times in the M. tuberculosis ORF FT O33341|MTV003.05c|AL008883." FT /db_xref="InterPro:IPR002035" FT /db_xref="UniProtKB/Swiss-Prot:P0A5D8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93845.1" FT /translation="MAKSDGDDPLRPASPRLRSSRRHSLRYSAYTGGPDPLAPPVDLRD FT ALEQIGQDVMAGASPRRALSELLRRGTRNLTGADRLAAEVNRRRRELLRRNNLDGTLQE FT IKKLLDEAVLAERKELARALDDDARFAELQLDALPASPAKAVQELAEYRWRSGQAREKY FT EQIKDLLGRELLDQRFAGMKQALAGATDDDRRRVTEMLDDLNDLLDKHARGEDTQRDFD FT EFMTKHGEFFPENPRNVEELLDSLAKRAAAAQRFRNSLSQEQRDELDALAQQAFGSPAL FT MRALDRLDAHLQAARPGEDWTGSQQFSGDNPFGMGEGTQALADIAELEQLAEQLSQSYP FT GASMDDVDLDALARQLGDQAAVDARTLAELERALVNQGFLDRGSDGQWRLSPKAMRRLG FT ETALRDVAQQLSGRHGERDHRRAGAAGELTGATRPWQFGDTEPWHVARTLTNAVLRQAA FT AVHDRIRITVEDVEVAETETRTQAAVALLVDTSFSMVMENRWLPMKRTALALHHLVCTR FT FRSDALQIIAFGRYARTVTAAELTGLAGVYEQGTNLHHALALAGRHLRRHAGAQPVVLV FT VTDGEPTAHLEDFDGDGTSVFFDYPPHPRTIAHTVRGFDDMARLGAQVTIFRLGSDPGL FT ARFIDQVARRVQGRVVVPDLDGLGAAVVGDYLRFRRR" FT CDS 86984..87367 FT /transl_table=11 FT /gene="Mb0985" FT /locus_tag="Mb0985" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0985, -, len: 127 aa. Equivalent to Rv0960, len: FT 127 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 127 aa overlap). Conserved hypothetical FT protein, similar to other Mycobacterium tuberculosis FT hypothetical proteins e.g. Rv0065|MTV030.08 (133 aa), FASTA FT scores: E(): 1.5e-14, (38.3% identity in 128 aa overlap), FT Rv1720c (129 aa), and Rv0549c (137 aa)." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/Swiss-Prot:P64774" FT /protein_id="CAD93846.1" FT /translation="MIVVDASAALAALLNDGQARQLIAAERLHVPHLVDSEIASGLRRL FT AQRDRLGAADGRRALQTWRRLAVTRYPVVGLFERIWEIRANLSAYDASYVALAEALNCA FT LVTADLRLSDTGQAQCPITVVPR" FT CDS 87513..87860 FT /transl_table=11 FT /gene="Mb0986" FT /locus_tag="Mb0986" FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0986, -, len: 115 aa. Equivalent to Rv0961, len: FT 115 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 115 aa overlap). Probable integral membrane FT protein." FT /db_xref="GOA:P64776" FT /db_xref="UniProtKB/Swiss-Prot:P64776" FT /protein_id="CAD93847.1" FT /translation="MRVPSQWMISSRVTVAWNIVGYLVYAALAFVGGFAVWFSLFFAMA FT TDGCHDSACDASYHVFPAMVTMWIGVGAVLLLTLVVMVRNSSRGNVVIGWPFVGLLALG FT LVYVAADAVLH" FT CDS complement(87879..88553) FT /transl_table=11 FT /gene="lprP" FT /locus_tag="Mb0987c" FT /product="POSSIBLE LIPOPROTEIN LPRP" FT /note="Mb0987c, lprP, len: 224 aa. Equivalent to Rv0962c, FT len: 224 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 224 aa overlap). Possible lprP, FT lipoprotein. Contains possible N-terminal signal sequence FT and appropriately positioned PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="GOA:P59987" FT /db_xref="UniProtKB/Swiss-Prot:P59987" FT /protein_id="CAD93848.1" FT /translation="MKRTSRSLTAALLGIAALLAGCIKPNTFDPYANPGRGELDRRQKI FT VNGRPDLETVQQQLANLDATIRAMIAKYSPQTRFSTGVTVSHLTNGCNDPFTRTIGRQE FT ASELFFGRPAPTPQQWLQIVTELAPVFKAAGFRPNNSVPGDPPQPLGAPNYSQIRDDGV FT TINLVNGDNRGPLGYSYNTGCHLPAAWRTAPPPLNMRPANDPDVHYPYLYGSPGGRTRD FT AY" FT CDS complement(88736..89536) FT /transl_table=11 FT /gene="Mb0988c" FT /locus_tag="Mb0988c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0988c, -, len: 266 aa. Equivalent to Rv0963c, len: FT 266 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 266 aa overlap). Conserved hypothetical FT protein, similar in part to other CONSERVED HYPOTHETICAL FT PROTEINS from Mycobacterium tuberculosis e.g. FT Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: E(): 1.2e-23, FT (39.0% identity in 254 aa overlap); Rv2542 (403 aa); Rv2079 FT (656 aa). Also similar in part to AL133423|SC4A7_3 FT HYPOTHETICAL SECRETED PROTEIN from Streptomyces coelicolor FT (406 aa), FASTA scores: opt: 231, E(): 6.8e-07, (31.4% FT identity in 204 aa overlap); and SCH10.21c|T36533 FT hypothetical protein from Streptomyces coelicolor (329 FT aa)." FT /db_xref="InterPro:IPR010427" FT /db_xref="UniProtKB/Swiss-Prot:P64778" FT /protein_id="CAD93849.1" FT /translation="MLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTSL FT ILLDTASDPRKVLAAVGVGDVDNAERVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAAEL FT RERAGWPNYDAVASIAWLGYDAPDGLKDVMHDWSARDAAGPLNRFDKGLAATTNVSDQH FT ITAFGHSYGSLVTSLALQQGAPVSDVVLYGSPGTELTHASQLGVEPGHAFYMIGVNDHV FT ANTIPEFGAFGSAPQDVPGMTQLSVNTGLAPGPLLGDGQLHERA" FT CDS complement(89635..90117) FT /transl_table=11 FT /gene="Mb0989c" FT /locus_tag="Mb0989c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0989c, -, len: 160 aa. Equivalent to Rv0964c, len: FT 160 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 160 aa overlap). Hypothetical unknown FT protein. Equivalent to AAK45241.1 from Mycobacterium FT tuberculosis strain CDC1551 (138 aa) but longer 22 aa." FT /db_xref="UniProtKB/Swiss-Prot:P59978" FT /protein_id="CAD93850.1" FT /translation="MGLLGFGGAAAEAAQVATHHTTVLLDHHAGACEAVARAAEKAAEE FT VAAIKMRLQVIRDAAREHHLTIAYATGTALPPPDLSSYSPADQQAILNTAIRRASNVCW FT PTPRPPMRIWPRRFDAPPGTCRASRSMPNSAMRHPQCRRCRRRTATLRRSSGGGIR" FT CDS complement(90217..90636) FT /transl_table=11 FT /gene="Mb0990c" FT /locus_tag="Mb0990c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0990c, -, len: 139 aa. Equivalent to Rv0965c, len: FT 139 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 139 aa overlap). Conserved hypothetical FT protein, showing weak similarity with Rv2798c|MTCY16B7.45 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (108 aa), FASTA scores: E(): 5.6e-12, (38.9% FT identity in 90 aa overlap). Equivalent to AAK45242.1 from FT Mycobacterium tuberculosis strain CDC1551 (146 aa) but FT shorter 7 aa." FT /db_xref="UniProtKB/TrEMBL:Q7U0Y7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93851.1" FT /translation="MRVNRPQCARVPYSAESLVRVEASWYGRTLRAIPEVLSQVGYQQA FT DHGESLLTSHHCCLGAAEGARPGWVGSSAGALSGLLDSWAEASTAHAAHIGDHSYGMHL FT AAVGFAEMEEHNAAALAAVYPTGGGSARCDGVDVS" FT CDS complement(90672..91274) FT /transl_table=11 FT /gene="Mb0991c" FT /locus_tag="Mb0991c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0991c, -, len: 200 aa. Equivalent to Rv0966c, len: FT 200 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.0% identity in 200 aa overlap). Conserved hypothetical FT protein, equivalent to AL035500|MLCL373_12 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (200 aa), FT FASTA scores: opt: 1080, E(): 0, (79.5% identity in 200 aa FT overlap). Also highly similar to FT SCE6.30c|CAB88834.1|AL353832 hypothetical protein from FT Streptomyces coelicolor (277 aa). Some similarity to FT Rv2862c|MTV007.08 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (194 aa), FASTA scores: E(): FT 3.1e-06, (31.5% identity in 184 aa overlap). Equivalent to FT AAK45243.1 from Mycobacterium tuberculosis strain CDC1551 FT (230 aa) but shorter 30 aa. Note that Rv0966c has been FT shortened since first entry." FT /db_xref="InterPro:IPR012551" FT /db_xref="UniProtKB/TrEMBL:Q7U0Y6" FT /protein_id="CAD93852.1" FT /translation="MSNSAQRDARNSRDESARASDTDRIQIAQLLAYAAEQGRLQLTDY FT EDRLARAYAATTYQELDRLRADLPGAAIGPRRGGECNPAPSTLLLALLGGFERRGRWNV FT PKKLTTFTLWGSGVLDLRYADFTSTEVDIRAYSIMGAQTILLPPEVNVEIHGHRVMGGF FT DRKVVGEGTRGAPTVRIRGFSLGGDVGIKRKPRKPRK" FT CDS 91414..91773 FT /transl_table=11 FT /gene="Mb0992" FT /locus_tag="Mb0992" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0992, -, len: 119 aa. Equivalent to Rv0967, len: FT 119 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 119 aa overlap). Conserved hypothetical FT protein, similar to hypothetical proteins from several FT organisms e.g. AE002074|AE002074_11 from Deinococcus FT radiodurans (102 aa), FASTA scores: opt: 233, E(): 8.6e-10, FT (47.0% identity in 83 aa overlap); O32222|Z99121|YVGZ from FT Bacillus subtilis (101 aa), FASTA scores: opt:228, E(): FT 3.2e-15, (38.0% identity in 92 aa overlap); etc. Also FT similar to Mycobacterium tuberculosis hypothetical proteins FT Rv0190, and Rv1766." FT /db_xref="GOA:Q7U0Y5" FT /db_xref="InterPro:IPR003735" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0Y5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93853.1" FT /translation="MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISA FT VQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAV FT GESATEEPMPDASNM" FT CDS 91830..92126 FT /transl_table=11 FT /gene="Mb0993" FT /locus_tag="Mb0993" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0993, -, len: 98 aa. Equivalent to Rv0968, len: 98 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 98 aa overlap). Conserved hypothetical protein, FT similar to NP_301579.1|NC_002677 conserved hypothetical FT protein from Mycobacterium leprae (92 aa). Also highly FT similar to CONSERVED HYPOTHETICAL PROTEINS from FT Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA FT score: (51.1% identity in 94 aa overlap); and Rv1993c (90 FT aa)." FT /db_xref="InterPro:IPR009963" FT /db_xref="UniProtKB/Swiss-Prot:P64780" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93854.1" FT /translation="MVWHGFLAKAVPTVVTGAVGVAAYEALRKMVVKAPLRAATVSVAA FT WGIRLAREAERKAGESAEQARLMFADVLAEASERAGEEVPPLAVAGSDDGHDH" FT CDS 92182..94494 FT /transl_table=11 FT /gene="ctpV" FT /locus_tag="Mb0994" FT /product="PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE FT CTPV" FT /EC_number="3.6.3.-" FT /note="Mb0994, ctpV, len: 770 aa. Equivalent to Rv0969, FT len: 770 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 770 aa overlap). Probable ctpV, metal FT cation transporter P-type ATPase (transmembrane protein) FT (EC 3.6.3.-), highly similar (except in N-terminus) to FT others e.g. NP_391230.1|NC_000964 similar to heavy FT metal-transporting ATPase from Bacillus subtilis (803 aa); FT P37279|ATCS_SYNP7|PACS cation-transporting ATPase from FT Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) FT (747 aa), FASTA scores: opt: 1851, E(): 0, (52.1% identity FT in 664 aa overlap); etc. Equivalent to AAK45246.1 from FT Mycobacterium tuberculosis strain CDC1551 (792 aa) but FT shorter 22 aa. Contains PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES)." FT /db_xref="GOA:Q7U0Y4" FT /db_xref="InterPro:IPR018303" FT /db_xref="UniProtKB/TrEMBL:Q7U0Y4" FT /protein_id="CAD93855.1" FT /translation="MRVCVTGFNVDAVRAVAIEETVSQVTGVHAVHAYPRTASVVIWYS FT PELGDTAAVLSAITKAQHVPAELVPARAPHSAGVRGVGVVRKITGGIRRMLSRPPGVDK FT PLKASRCGGRPRGPVRGSASWPGEQNRRERRTWLPRVWLALPLGLLALGSSMFFGAYPW FT AGWLAFAATLPVQFVAGWPILRGAVQQARALTSNMDTLIALGTLTAFVYSTYQLFAGGP FT LFFDTSALIIAFVVLGRHLEARATGKASEAISKLLELGAKEATLLVDGQELLVPVDQVQ FT VGDLVRVRPGEKIPVDGEVTDGRAAVDESMLTGESVPVEKTAGDRVAGATVNLDGLLTV FT RATAVGADTALAQIVRLVEQAQGDKAPVQRLADRVSAVFVPAVIGVAVATFAGWTLIAA FT NPVAGMTAAVAVLIIACPCALGLATPTAIMVGTGRGAELGILVKGGEVLEASKKIDTVV FT FDKTGTLTRARMRVTDVIAGQRRQPNQVLRLAAAVESGSEHPIGAAIVAAAHERGLAIP FT AANAFTAVAGHGVRAQVNGGPVVVGRRKLVDEQHLVLPDHLAAAAVEQEERGRTAVFVG FT QDGQVVGVLAVADTVKDDAADVVGRLHAMGLQVAMITGDNARTAAAIAKQVGIEKVLAE FT VLPQDKVAEVRRLQDQGRVVAMVGDGVNDAPALVQADLGIAIGTGTDVAIEASDITLMS FT GRLDGVVRAIELSRQTLRTIYQNLGWAFGYNTAAIPLAALGALNPVVAGAAMGFSSVSV FT VTNSLRLRRFGRDGRTA" FT CDS 94491..95123 FT /transl_table=11 FT /gene="Mb0995" FT /locus_tag="Mb0995" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0995, -, len: 210 aa. Equivalent to Rv0970, len: FT 210 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 210 aa overlap). Probable conserved integral FT membrane protein, equivalent to NP_302348.1|NC_002677 FT probable integral membrane protein from Mycobacterium FT leprae (210 aa)." FT /db_xref="GOA:P64782" FT /db_xref="UniProtKB/Swiss-Prot:P64782" FT /protein_id="CAD93856.1" FT /translation="MIHDLMLRWVVTGLFVLTAAECGLAIIAKRRPWTLIVNHGLHFAM FT AVAMAVMAWPWGARVPTTGPAVFFLLAAVWFGATAVVAVRGTATRGLYGYHGLMMLATA FT WMYAAMNPRLLPVRSCTEYATEPDGSMPAMDMTAMNMPPNSGSPIWFSAVNWIGTVGFA FT VAAVFWACRFVMERRQEATQSRLPGSIGQAMMAAGMAMLFFAMLFPV" FT CDS complement(95214..96023) FT /transl_table=11 FT /gene="echA7" FT /locus_tag="Mb0996c" FT /product="PROBABLE ENOYL-COA HYDRATASE ECHA7 (ENOYL FT HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)" FT /EC_number="4.2.1.17" FT /note="Mb0996c, echA7, len: 269 aa. Equivalent to Rv0971c, FT len: 269 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 269 aa overlap). Probable echA7, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to many e.g. FT CAB95895.1|AL359988 putative enoyl CoA hydratase from FT Streptomyces coelicolor (247 aa); P24162|ECHH_RHOCA FT enoyl-CoA hydratase from Rhodobacter capsulatus (257 aa), FT FASTA scores: opt: 369, E(): 2.6e-15, (33.7% identity in FT 246 aa overlap); etc." FT /db_xref="GOA:Q7U0Y3" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:Q7U0Y3" FT /protein_id="CAD93857.1" FT /translation="MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLSA FT AEADPAVRLVVLGHTGGTFCAGADLSEAGGGGGDPYRMAVARAREMTALLRAIVESPLP FT VVGAINGHVRAGGFGLVGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPRAAA FT RYYLTGEKFGAREAADIGLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTAAVLE FT GFDRDAERLTEESARLFVSDEAREGMLAFLQKRPPRWVQPATMRAAD" FT CDS complement(96023..97189) FT /transl_table=11 FT /gene="fadE12" FT /locus_tag="Mb0997c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE12" FT /EC_number="1.3.99.-" FT /note="Mb0997c, fadE12, len: 388 aa. Equivalent to Rv0972c, FT len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 388 aa overlap). Probable fadE12, FT acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to FT many e.g. CAB95893.1|AL359988 putative acyl CoA FT dehydrogenase from Streptomyces coelicolor (382 aa); FT P45857|ACDB_BACSU from Bacillus subtilis (379 aa), FASTA FT scores: opt: 576, E(): 2.3e-26, (29.7% identity in 381 aa FT overlap); etc." FT /db_xref="GOA:Q7U0Y2" FT /db_xref="InterPro:IPR013764" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0Y2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93858.1" FT /translation="MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSELW FT AEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSPAINGTIIAKFG FT TDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFISGID FT QAQAVLVVGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSPERQFQVFLDDVRLP FT ADALVGAEDAAIAHLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQ FT GLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQ FT SMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY" FT CDS complement(97186..99189) FT /transl_table=11 FT /gene="accA2" FT /locus_tag="Mb0998c" FT /standard_name="bccA" FT /product="PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE FT ALPHA CHAIN (ALPHA SUBUNIT) ACCA2: BIOTIN CARBOXYLASE + FT BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)" FT /EC_number="6.3.4.14" FT /note="Mb0998c, accA2, len: 667 aa. Equivalent to Rv0973c, FT len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 667 aa overlap). Probable accA2 FT (alternate gene name: bccA), acetyl-/propionyl-coenzyme A FT carboxylase (alpha subunit) [INCLUDES: BIOTIN CARBOXYLASE FT (EC 6.3.4.14); BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)], FT highly similar to others e.g. CAB95892.1|AL359988 putative FT acetyl/propionyl CoA carboxylase alpha subunit from FT Streptomyces coelicolor (614 aa); NP_250702.1|NC_002516 FT probable acyl-CoA carboxylase alpha chain from Pseudomonas FT aeruginosa (655 aa); NP_420971.1|NC_002696 FT acetyl/propionyl-CoA carboxylase alpha subunit from FT Caulobacter crescentus ( 654 aa); NP_251581.1|NC_002516 FT probable biotin carboxylase/biotin carboxyl carrier protein FT from Pseudomonas aeruginosa (661 aa); etc. Also highly FT similar to others from Mycobacterium tuberculosis e.g. FT Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 PROBABLE FT ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA FT SUBUNIT) (654 aa), FASTA scores, opt: 250, E(): 4e-09, FT (28.6% identity in 182 aa overlap); and FT Rv3285|MTCY71.25|ACCA3 (600 aa); Z83018|MTCY349_20 (1127 FT aa), FASTA scores: opt: 838, E(): 0, (40.2% identity in 500 FT aa overlap). Contains PS00867 Carbamoyl-phosphate synthase FT subdomain signature 2 and PS00188 Biotin-requiring enzymes FT attachment site." FT /db_xref="GOA:Q7U0Y1" FT /db_xref="HSSP:1BNC" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/TrEMBL:Q7U0Y1" FT /protein_id="CAD93859.1" FT /translation="MGITRVLVANRGEIARRVFATCRRLGLGTVAVYTDPDAAAPHVAE FT ADARVRLPQTTDYLNAEAIIAAAQAAGADAVHPGYGFLSENAEFAAAVQEAGLTWVGPP FT VDAVRAMGSKIESKKLMAAAGVPVLEELDPDAVTTAQLPVLVKASAGGGGRGMRVVHEL FT SALPAEVEAARREAQSAFGDPTVFCERYLPTGHHVEVQVMADTHGTVWAVGERECSFQR FT RHQKIIEEAPSPLVERVPGMRAKLFDAARLAASAIGYTGAGTVEFLADDSPGREGEFYF FT LEMNTRLQVEHPVTEETTGLDLVELQLMIADCGRLDTEPPPAQGYSIEARLYAEDPAHG FT WQPQAGVMHTIEVPGVRAQFDSLGQRTGIRLDSGIVDGSTVSIHYDPMLAKVVSYGATR FT RQAALVLADALVRARLHGLRTNRELLVNVLRHPAFLDGATDTGFFDTHGMAELSTPLAD FT TATLRLSAIAAALADAEHNRASAGVFSSIPSGWRNLASGYQVKTYRDDADTEHRVEYRF FT TRTGLALPGDPVVQLVSADVDQVVLAQDGVAHGFTVARHGPDVYVDSARGPVHLVALSR FT FPEPSSAVEQGSLVAPMPGNVIRIGAEVGDTVTAGQPLIWLEAMKMEHTIAAPADGVLT FT HVSVNTGQQVEVGAILARVEAPQNGPAEGDSP" FT CDS complement(99195..100784) FT /transl_table=11 FT /gene="accD2" FT /locus_tag="Mb0999c" FT /product="PROBABLE ACETYL-/PROPIONYL-COA CARBOXYLASE (BETA FT SUBUNIT) ACCD2" FT /EC_number="6.4.1.-" FT /note="Mb0999c, accD2, len: 529 aa. Equivalent to Rv0974c, FT len: 529 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 529 aa overlap). Probable accD2, FT acetyl-/propionyl-CoA carboxylase (beta subunit) (EC FT 6.4.1.-), highly similar to many e.g. CAB95891.1|AL35998 FT putative acetyl/propionyl CoA carboxylase beta subunit from FT Streptomyces coelicolor (532 aa); NP_250704.1|NC_002516 FT probable acyl-CoA carboxyltransferase beta chain from FT Pseudomonas aeruginosa (535 aa); BAB16296.1|AB039884 FT acetyl-CoA carboxylase carboxyltransferase from Myxococcus FT xanthus (538 aa); NP_420973.1|NC_002696 putative FT propionyl-CoA carboxylase beta subunit from Caulobacter FT crescentus (530 aa); etc. Also similar to other from FT Mycobacterium tuberculosis: Rv2502c|ACCD1, Rv3799c|ACCD4, FT etc. COULD BELONG TO THE ACCD/PCCB FAMILY." FT /db_xref="GOA:Q7U0Y0" FT /db_xref="InterPro:IPR011762" FT /db_xref="UniProtKB/TrEMBL:Q7U0Y0" FT /protein_id="CAD93860.1" FT /translation="MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDR FT HHARGKLTPRERIELLVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVAN FT DPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDL FT TRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDD FT ESLGGAEMHARISGLADYFALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEEL FT IGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGV FT LFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTV FT PHISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEAR FT GQQVDEAADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGP FT IKGTSNFGVFRM" FT CDS complement(100825..101934) FT /transl_table=11 FT /gene="fadE13" FT /locus_tag="Mb1000c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE13" FT /EC_number="1.3.99.-" FT /note="Mb1000c, fadE13, len: 369 aa. Equivalent to the 5' FT end of Rv0975c, len: 382 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100% identity in 349 aa FT overlap). Probable fadE13, acyl-CoA dehydrogenase (EC FT 1.3.99.-), highly similar to many e.g. T35427 probable FT acyl-CoA dehydrogenase from Streptomyces coelicolor (382 FT aa); M74096|HUMACADL_1 Human long chain acyl-CoA FT dehydrogenase from Homo sapiens (430 aa), FASTA scores: FT opt: 819, E(): 0, (37.0% identity in 376 aa overlap); etc. FT Also similar to others from Mycobacterium tuberculosis e.g. FT fadE20|Z98209|MTCY154_4 (386 aa), FASTA scores: (40.3% FT identity in 375 aa overlap). Contains PS00073 Acyl-CoA FT dehydrogenases signature 2. BELONGS TO THE ACYL-COA FT DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a frameshift due to a single base FT deletion (t-*) leads to a shorter product with a different FT COOH part compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv." FT /db_xref="GOA:Q7U0X9" FT /db_xref="HSSP:1JQI" FT /db_xref="InterPro:IPR013786" FT /db_xref="UniProtKB/TrEMBL:Q7U0X9" FT /protein_id="CAD93861.1" FT /translation="MNIWTTPERQQLRKTVRAFAEREILPHVDEWERIGELPRGLHRLA FT GAAGLLGAGFPEAVGGGGGDGADPVIICEEMHQAGAPGGVYASLFTCGIAVPHMVASGD FT ERLIATYVRPTLAGEKIGALAITEPGGGSDVGHLRTSAVRDGDHYVINGAKTYITSGVR FT ADYVVTAVRTGGPGAAGVSLLVVEKDTPGFEVTRKLDKMGWRSSDTAELCYTDVAVPAT FT NLVGAENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRPLISRQSV FT QNTLAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTAVQAGEWVANQAVQLFG FT GMGYMAESEANANTGTCESSVSEAAPPKY" FT CDS complement(101931..103613) FT /transl_table=11 FT /gene="Mb1001c" FT /locus_tag="Mb1001c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1001c, -, len: 560 aa. Equivalent to Rv0976c, len: FT 560 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 560 aa overlap). Conserved hypothetical FT protein, highly similar to others e.g. CAB95890.1|AL359988 FT conserved hypothetical protein from Streptomyces coelicolor FT (558 aa); P_251576.1|NC_002516 hypothetical protein from FT Pseudomonas aeruginosa (600 aa); etc. N-terminal part FT highly similar to AL035500|MLCL373_14 probable pseudogene FT from Mycobacterium leprae (163 aa), FASTA score: (50.0% FT identity in 122 aa overlap)." FT /db_xref="InterPro:IPR010839" FT /db_xref="UniProtKB/TrEMBL:Q7TVC1" FT /protein_id="CAD93862.1" FT /translation="MRIGNCSGFYGDRLSAMREMLTGGELDYLTGDYLAELTMLILGRD FT RMKNPDRGYAKTFLAQLEDCLGLAHDRGVRIVTNAGGLNPAGLANAVRALAARLGIPAQ FT VAHVEGDDLQPRAAELGLGTPLTANAYLGAWGIVDCFERGADVVVTGRVTDASVVVGAA FT AAHFGWGRTDYHRLAGAVVAGHVIECGVQATGGNYAFFTEIGDLTHAGFPLAEIAADGS FT SVITKHHGTGGLVSVDTITAQLLYEITGARYANPDVTARMDSVELSPDGPDRVRISGVI FT GEPPPPTYKVSLNSIGGFRNAMTFVLTGLDIDAKADLVRRQLEAALTVKPAELQWTLAR FT TDHPDADTEETASALLTCVARDPDPANVGRQFSSAAVELALASYPGFTATAPPGDGQVY FT GVFTPGYVDAGKVAHIAVHADGTRTEIPCATETLELAPAHPPALPDPLPAGPTRRVPLG FT LIAGARSGDKGGSANVGVWVRTDEQWRWLAHTLTVELLKELLPETAGLVVTRHVLPNLR FT ALNFVIEAILGQGVAYQARFDPQAKGLGEWLRSRHVEIPETLL" FT CDS 103812..106583 FT /transl_table=11 FT /gene="PE_PGRS16" FT /locus_tag="Mb1002" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1002, PE_PGRS16, len: 923 aa. Equivalent to FT Rv0977, len: 923 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100% identity in 923 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, highly similar to other PGRS-type FT sequences e.g. AL0091|MTV004_1 from Mycobacterium FT tuberculosis (1125 aa), FASTA score: (45.4% identity in 959 FT aa overlap); Z80225|MTCY441_4 from Mycobacterium FT tuberculosis (778 aa), FASTA score: (51.5% identity in 750 FT aa overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0X8" FT /protein_id="CAD93863.1" FT /translation="MSFVVTAPPVLASAASDLGGIASMISEANAMAAVRTTALAPAAAD FT EVSAAIAALFSSYARDYQTLSVQVTAFHVQFAQTLTNAGQLYAVVDVGNGVLLKTEQQV FT LGVINAPTQTLVGRPLIGDGTHGAPGTGQNGGAGGILWGNGGNGGSGAPGQPGGRGGDA FT GLFGHGGHGGVGGPGIAGAAGTAGLPGGNGANGGSGGIGGAGGAGGNGGLLFGNGGAGG FT QGGSGGLGGSGGTGGAGMAAGPAGGTGGIGGIGGIGGAGGVGGHGSALFGHGGINGDGG FT TGGMGGQGGAGGNGWAAEGITVGIGEQGGQGGDGGAGGAGGIGGSAGGIGGSQGAGGHG FT GDGGQGGAGGSGGVGGGGAGAGGDGGAGGIGGTGGNGSIGGAAGNGGNGGRGGAGGMAT FT AGSDGGNGGGGGNGGVGVGSAGGAGGTGGDGGAAGAGGAPGHGYFQQPAPQGLPIGTGG FT TGGEGGAGGAGGDGGQGDIGFDGGRGGDGGPGGGGGAGGDGSGTFNAQANNGGDGGAGG FT VGGAGGTGGTGGVGADGGRGGDSGRGGDGGNAGHGGAAQFSGRGAYGGEGGSGGAGGNA FT GGAGTGGTAGSGGAGGFGGNGADGGNGGNGGNGGFGGINGTFGTNGAGGTGGLGTLLGG FT HNGNIGLNGATGGIGSTTLTNATVPLQLVNTTEPVVFISLNGGQMVPVLLDTGSTGLVM FT DSQFLTQNFGPVIGTGTAGYAGGLTYNYNTYSTTVDFGNGLLTLPTSVNVVTSSSPGTL FT GNFLSRSGAVGVLGIGPNNGFPGTSSIVTAMPGLLNNGVLIDESAGILQFGPNTLTGGI FT TISGAPISTVAVQIDNGPLQQAPVMFDSGGINGTIPSALASLPSGGFVPAGTTISVYTS FT DGQTLLYSYTTTATNTPFVTSGGVMNTGHVPFAQQPIYVSYSPTAIGTTTFN" FT CDS complement(106800..107807) FT /transl_table=11 FT /gene="PE_PGRS17" FT /locus_tag="Mb1003c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1003c, PE_PGRS17, len: 335 aa. Similar to Rv0978c, FT len: 331 aa, from Mycobacterium tuberculosis strain H37Rv, FT (93.7% identity in 335 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, highly similar to others e.g. FT Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 FT aa), FASTA score: (73.6% identity in 277 aa overlap); etc. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT 115 bp to 127 bp substitution leads to a slightly longer FT product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (335 aa versus 331 aa)." FT /db_xref="InterPro:IPR015943" FT /db_xref="UniProtKB/TrEMBL:Q7U0X7" FT /protein_id="CAD93864.1" FT /translation="MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLVAAQDE FT VSTAIAALFGSHGQHYQAISAQVAAYQERFVLALSQAGSTYAVAEAASATPLQQIEQAL FT LGVINTPTEALVGRKLIGDGAHGAPGTGQAGGAGGILWGNGGNGGSGAPGQAGGAGGAA FT GLIGNGGAGGTGGAVSLARAGTAGGAGRGPVGGIGGAGGVGGAGGAAGAVTTITHASFN FT DPHGVAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVT FT NFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS" FT CDS complement(108121..108315) FT /transl_table=11 FT /gene="Mb1004c" FT /locus_tag="Mb1004c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1004c, -, len: 64 aa. Equivalent to Rv0979c, len: FT 64 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 64 aa overlap). Hypothetical unknown protein. FT Start codon changed since first submission (-44 aa)" FT /db_xref="UniProtKB/TrEMBL:Q7U0X6" FT /protein_id="CAD93865.1" FT /translation="MGFRTQVGAATIASTMTWRIPVEDGPAQFRAGVGPGRDRQFTVVA FT PMVVGLWDRNRRPGWQWPS" FT CDS 108337..108510 FT /transl_table=11 FT /gene="rpmF" FT /locus_tag="Mb1005" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L32 RPMF" FT /note="Mb1005, rpmF, len: 57 aa. Equivalent to Rv0979A, FT len: 57 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 57 aa overlap). Probable rpmF, 50S FT ribosomal protein L32, similar to others e.g. rpmF|Q9RL50 FT PROBABLE 50S RIBOSOMAL PROTEIN from Streptomyces coelicolor FT (56 aa), FASTA scores: E(): 5.1e-09, (63.45% identity in 52 FT aa overlap); etc. BELONGS TO THE L32P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P0A5V9" FT /db_xref="InterPro:IPR002677" FT /db_xref="UniProtKB/Swiss-Prot:P0A5V9" FT /protein_id="CAD93866.1" FT /translation="MAVPKRRKSRSNTRSRRSQWKAAKTELVGVTVAGHAHKVPRRLLK FT AARLGLIDFDKR" FT CDS complement(108529..109902) FT /transl_table=11 FT /gene="PE_PGRS18" FT /locus_tag="Mb1006c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1006c, PE_PGRS18, len: 457 aa. Equivalent to FT Rv0980c, len: 457 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.6% identity in 457 aa overlap). Member of FT the Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, highly similar to others e.g. FT Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 FT aa), FASTA score: (66.7% identity in 405 aa overlap); FT Z95844|MTCY493_2 from Mycobacterium tuberculosis (741 aa), FT FASTA score: (53.0% identity in 394 aa overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0X5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93867.1" FT /translation="MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDE FT VSTAIAALFGSHGQHYQAISAQVAAYQERFVLALSQASSTYAVAEAASATPLQNVLDAI FT NAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIG FT NGGAGGAGGQGLPFEAGANGGAGGAGGWLFGNGGAGGVGGAGGAGTTFGVAGGDGGTGG FT VGGHGGLIGVGGHGGDGGTGGTGGAVSLARAGTAGGAGGGPAGGIGGTGGVGGAGGAAG FT AVTTITHASFNDPHGVAVNPGGNIYVTNQGSNTVSVIDPVTNTVTGSITDGNGPSGVAV FT SPVTGLVFVTNFDSNTVSVIDPNTNTVTGSIPVGTGAYGVAVNPGGNIYVTNQFSNTVS FT VIDPATNTVTGSPIPVGLDPTGVAVNPVTGVVYVTNSLDDTVSVITGEPARSVCSAAI" FT CDS 110267..110959 FT /transl_table=11 FT /gene="mprA" FT /locus_tag="Mb1007" FT /product="MYCOBACTERIAL PERSISTENCE REGULATOR MRPA (TWO FT COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN)" FT /note="Mb1007, mprA, len: 230 aa. Equivalent to Rv0981, FT len: 230 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 230 aa overlap). mprA, mycobacterial FT persistence regulator, a two-component response regulator FT whose expression is required for entrance into and FT maintenance of persistent infection (see citation below), FT equivalent to NP_301250.1|NC_002677 putative two-component FT response regulator from Mycobacterium leprae (228 aa); and FT highly similar to others from Mycobacterium leprae. Also FT highly similar to others e.g. FT AAG36759.1|AF119221_1|AF119221 response regulator from FT Corynebacterium glutamicum (232 aa); CAB88489.1|AL353816 FT putative two-component system response regulator from FT Streptomyces coelicolor (248 aa); BJY09666_1 two-component FT response regulator (ragA, ragB and rpoH3) from B.japonicum FT (226 aa), FASTA score: (43.8% identity in 224 aa overlap); FT BSAJ2571_44 two-component response regulator from Bacillus FT subtilis (228 aa), FASTA score: (46.4% identity in 224 aa FT overlap); etc. Also highly similar to others from FT Mycobacterium tuberculosis e.g. Rv1033c (257 aa); Rv0903c FT (236 aa), FASTA score: (50.7 identity in 225 aa overlap); FT etc. Contains PS00217 Sugar transport proteins signature FT 2." FT /db_xref="GOA:Q7U0X4" FT /db_xref="HSSP:1KGS" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0X4" FT /protein_id="CAD93868.1" FT /translation="MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASD FT RPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKP FT FALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALL FT EMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVG FT YVLRETPP" FT CDS 110959..112473 FT /transl_table=11 FT /gene="mprB" FT /locus_tag="Mb1008" FT /product="PROBABLE TWO COMPONENT SENSOR KINASE MPRB" FT /EC_number="2.7.3.-" FT /note="Mb1008, mprB, len: 504 aa. Equivalent to Rv0982, FT len: 504 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 504 aa overlap). Probable mprB, two FT component sensor kinase, transmembrane protein (EC 2.7.3.-) FT (see citation below), equivalent to FT AL035500|MLCL373_16|NP_301251.1|NC_002677 putative FT two-component system sensor kinase from Mycobacterium FT leprae (519 aa), FASTA score: (81.0% identity in 521 aa FT overlap). Also highly similar to others (especially in FT C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221 sensor FT kinase from Corynebacterium glutamicum (455 aa); FT CAB89748.1|AL354616 putative two-component histidine kinase FT from Streptomyces coelicolor (481 aa); X58793|SLCUTRS_2 FT sensor kinase from S.lividans (414 aa), FASTA scores: opt: FT 451, E(): 4.2e-21, (36.0% identity in 303 aa overlap); FT P30847|BAES_ECOLI SENSOR PROTEIN (EC 2.7.3.-) from FT Escherichia coli (467 aa), FASTA scores: opt: 412, E(): FT 1.3e-18, (30.4% identity in 336 aa overlap); etc. Also FT similar in C-terminal region to C-terminus of FT Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis FT (446 aa), FASTA scores: opt: 423, E(): 2.6e-19, (28.4 FT identity in 462 aa overlap)." FT /db_xref="GOA:Q7U0X3" FT /db_xref="HSSP:1BXD" FT /db_xref="InterPro:IPR003594" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0X3" FT /protein_id="CAD93869.1" FT /translation="MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYA FT VISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQ FT PGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLR FT WVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARL FT TEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEM FT VDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDIHF FT DVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPG FT IPVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSI FT YVLLPGRRMPIPQLPGATAGARSTDIENSRGSANVISVESQSTRAT" FT CDS 112517..113911 FT /transl_table=11 FT /gene="Mb1009" FT /locus_tag="Mb1009" FT /product="PROBABLE SERINE PROTEASE (SERINE PROTEINASE)" FT /EC_number="3.4.21.-" FT /note="Mb1009, -, len: 464 aa. Equivalent to Rv0983, len: FT 464 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 464 aa overlap). Probable secreted or FT membrane serine protease (EC 3.4.21.-), equivalent (but FT longer 18 aa in N-terminus) to AL035500|MLCL373_17|T45448 FT probable serine proteinase (EC 3.4.21.-) from Mycobacterium FT leprae (452 aa), FASTA score: (74.2% identity in 466 aa FT overlap); and highly similar to others from Mycobacterium FT leprae. Also highly similar (except in N-terminus) to other FT proteases e.g. CAC01350.1|AL390975 putative protease from FT Streptomyces coelicolor (542 aa); FT NP_440705.1|NC_000911|HtrA serine protease from FT Synechocystis sp. (452 aa); NP_346646.1|NC_003028 serine FT protease from Streptococcus pneumoniae (393 aa); etc. Also FT similar in part to members of the htrA-antigen family e.g. FT U87242|MTU87242_3|HtrA serine protease from M. tuberculosis FT (542 aa), FASTA scores: opt: 846, E(): 2e-28, (40.6% FT identity in 392 aa overlap); and similar to other FT hypothetical serine proteases e.g. Rv0983, Rv0125, etc." FT /db_xref="GOA:Q7U0X2" FT /db_xref="InterPro:IPR001254" FT /db_xref="UniProtKB/TrEMBL:Q7U0X2" FT /protein_id="CAD93870.1" FT /translation="MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTY FT SQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAI FT GAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKV FT VPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGR FT TAPFTVVGADPTSDIAVVRVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTG FT IVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGA FT DSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTPGAKIVEVVA FT GGAAANAGVPKGVVVTKVDDRPINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVT FT LGKAEQ" FT CDS 113911..114456 FT /transl_table=11 FT /gene="moaB2" FT /locus_tag="Mb1010" FT /product="POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FT MOAB2 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) FT (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE FT HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN FT CARBINOLAMINE DEHYDRATASE) (PCD)" FT /EC_number="4.2.1.96" FT /note="Mb1010, moaB2, len: 181 aa. Equivalent to Rv0984, FT len: 181 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 181 aa overlap). Possible moaB2, FT pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), FT highly similar to NP_301253.1|NC_002677 putative molybdenum FT cofactor biosynthesis protein from Mycobacterium leprae FT (181 aa), FASTA score: (92.3% identity in 181 aa overlap). FT Also similar to others e.g. CAB59675.1|AL132674 molybdenum FT cofactor biosynthesis protein from Streptomyces coelicolor FT (179 aa); Q56208|MOCB_SYNP7 MOLYBDENUM COFACTOR FT BIOSYNTHESIS PROTEIN CB from Synechococcus sp. (319 aa), FT FASTA score: (37.3% identity in 142 aa overlap); C-terminus FT of NP_197599.1|NC_003076 MOLYBDOPTERIN BIOSYNTHESIS CNX1 FT PROTEIN from Arabidopsis thaliana (670 aa); etc. Also FT similar to Rv0865|MOG from Mycobacterium tuberculosis (160 FT aa); and other mog proteins e.g. CAC39235.1|AJ312124 Mog FT protein from Eubacterium acidaminophilum (162 aa). COULD FT BELONG TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FT FAMILY. Alternative start codon has been suggested in FT position 1100508." FT /db_xref="GOA:Q7TTP6" FT /db_xref="HSSP:1O8O" FT /db_xref="InterPro:IPR001453" FT /db_xref="UniProtKB/TrEMBL:Q7TTP6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93871.1" FT /translation="MKVAAQCSKLGYTVAPMEQRAELVVGRALVVVVDDRTAHGDEDHS FT GPLVTELLTEAGFVVDGVVAVSADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRDVTPE FT ATRDILDREILGIAEAIRASGLSAGIVDAGLSRGLAGVSGSTLVVNLAGSRYAVRDGMA FT TLNPLAAQIIGQLSSLEI" FT CDS complement(114476..114931) FT /transl_table=11 FT /gene="mscL" FT /locus_tag="Mb1011c" FT /product="POSSIBLE LARGE-CONDUCTANCE ION MECHANOSENSITIVE FT CHANNEL MSCL" FT /note="Mb1011c, mscL, len: 151 aa. Equivalent to Rv0985c, FT len: 151 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 151 aa overlap). Possible mscL, large FT conductance mechanosensitive ion channel (integral membrane FT protein), equivalent to FT AL035500|MLCL373_19|NP_301254.1|NC_002677 putative FT mechanosensitive channel protein from Mycobacterium leprae FT (154 aa), FASTA score: (71.0% identity in 155 aa overlap). FT Also highly similar to others e.g. NP_268999.1|NC_002737 FT putative large conductance mechanosensitive channel from FT Streptococcus pyogenes (120 aa); CAB90974.1|AL355832 FT putative mechanosensitive channel from Streptomyces FT coelicolor (156 aa); Q9X722|MSCL_CLOHI LARGE-CONDUCTANCE FT MECHANOSENSITIVE CHANNEL from Clostridium histolyticum (133 FT aa); Z83337|BSZ83337_6 large conductance mechanosensitive FT channel from Bacillus subtilis (130 aa), FASTA scores: opt: FT 248, E(): 8.4e-10, (39.0% identity in 136 aa overlap); FT U08371|ECU08371_1 large conductance mechanosensitive FT channel from Escherichia coli strain K-12 (136 aa), FASTA FT score: (36.6% identity in 134 aa overlap); etc. BELONGS TO FT THE MSCL FAMILY." FT /db_xref="GOA:P0A5K9" FT /db_xref="InterPro:IPR001185" FT /db_xref="UniProtKB/Swiss-Prot:P0A5K9" FT /protein_id="CAD93872.1" FT /translation="MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINR FT IGVNAQSDVGILRIGIGGGQTIDLNVLLSAAINFFLIAFAVYFLVVLPYNTLRKKGEVE FT QPGDTQVVLLTEIRDLLAQTNGDSPGRHGGRGTPSPTDGPRASTESQ" FT CDS 115254..116000 FT /transl_table=11 FT /gene="Mb1012" FT /locus_tag="Mb1012" FT /product="PROBABLE ADHESION COMPONENT TRANSPORT ATP-BINDING FT PROTEIN ABC TRANSPORTER" FT /note="Mb1012, -, len: 248 aa. Equivalent to Rv0986, len: FT 248 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 248 aa overlap). Probable ATP-binding FT protein ABC transporter supposed involved in transport of FT adhesion component (see citation below), highly similar to FT many ATP-binding proteins e.g. AE0010|AE001033_8 ABC FT transporter ATP-binding protein from Archaeoglobus fulgidus FT (228 aa), FASTA scores: opt: 669, E(): 0, (45.7% identity FT in 219 aa overlap); CAB81857.1|AL161691 putative FT ABC-transporter ATP-binding protein from Streptomyces FT coelicolor (246 aa); X84019|ZMDNAGRP_4 glutamate uptake FT regulatory protein (grp) from Z.mobilis (232 aa), FASTA FT score: (44.4% identity in 225 aa overlap); FT Z99111|BSUB0008_108 from Bacillus subtilis (230 aa), FASTA FT score: (38.7% identity in 222 aa overlap); etc. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 FT ABC transporters family signature. BELONGS TO THE FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." FT /db_xref="GOA:Q7U0X1" FT /db_xref="HSSP:1F3O" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U0X1" FT /protein_id="CAD93873.1" FT /translation="MNRQPIVQLSNLSWTFREGETRRQVLDHITFDFEPGEFVALLGQS FT GSGKSTLLNLISGIEKPTTGDVTINGFAITQKTERDRTLFRRDQIGIVFQFFNLIPTLT FT VLENITLPQELAGVSQRKAAVVARDLLEKVGMADRERTFPDKLSGGEQQRVAISRALAH FT NPMLVLADEPTGNLDSDTGDKVLDVLLDLTRQAGKTLIMATHSPSMTQHADRVVNLQGG FT RLIPALNRENQTDQPASTILLPTSYE" FT CDS 115993..117264 FT /transl_table=11 FT /gene="Mb1013" FT /locus_tag="Mb1013" FT /product="PROBABLE ADHESION COMPONENT TRANSPORT FT TRANSMEMBRANE PROTEIN ABC TRANSPORTER" FT /note="Mb1013, -, len: 423 aa. Equivalent to 5' end of FT Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100% identity in 423 aa overlap). Probable FT transmembrane protein ABC transporter supposed involved in FT transport of adhesion component (see citation below), whose FT N-terminus shows similarity with hypothetical proteins, FT generally transmembrane proteins, e.g. CAB96016.1|AL360055 FT putative ABC transport system integral membrane protein FT from Streptomyces coelicolor (855 aa); FT P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from FT Haemophilus influenzae (393 aa), FASTA scores: opt: 265, FT E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N- FT and C-termini respectively show similarity to O32735 ATTF FT PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity FT in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FT FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0987 exists as a single gene. FT In Mycobacterium bovis, a single base transition (g-a) FT introduces a stop codon that splits Rv0987 in two parts, FT Mb1013 and Mb1014." FT /db_xref="GOA:Q7U0X0" FT /db_xref="InterPro:IPR003838" FT /db_xref="UniProtKB/TrEMBL:Q7U0X0" FT /protein_id="CAD93874.1" FT /translation="MNDQAPVAYAPLWRTAWRRLRQRPFQYILLVLGIALGVAMIVAID FT VSSNSAQRAFDLSAAAITGKSTHRLVSGPAGVDQQLYVDLRRHGYDFSAPVIEGYVLAR FT GLGNRAMQFMGTDPFAESAFRSPLWSNQNIAELGGFLTRPNGVVLSRQVAQKYGLAVGD FT RIALQVKGAPTTVTLVGLLTPADEVSNQKLSDLIIADISTAQELFHMPGRLSHIDLIIK FT DEATATRIQQRLPAGVRMETSDTQRDTVKQMTDAFTVNLTALSLIALLVGIFLIYNTVT FT FNVVQRRPFFAILRCLGVTREQLFWLIMTESLVAGLIGTGLGLLIGIWLGEGLIGLVTQ FT TINDFYFVINVRNVSVSAESLLKGLIIGIFAAMLATLPPAIEAMRTVPASTLRRSSLES FT KITKLMPWLWVAWFGLGSFGVLML" FT CDS 117265..118560 FT /transl_table=11 FT /gene="Mb1014" FT /locus_tag="Mb1014" FT /product="PROBABLE ADHESION COMPONENT TRANSPORT FT TRANSMEMBRANE PROTEIN ABC TRANSPORTER" FT /note="Mb1014, -, len: 431 aa. Equivalent to 3' end of FT Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.8% identity in 431 aa overlap). Probable FT transmembrane protein ABC transporter supposed involved in FT transport of adhesion component (see citation below), whose FT N-terminus shows similarity with hypothetical proteins, FT generally transmembrane proteins, e.g. CAB96016.1|AL360055 FT putative ABC transport system integral membrane protein FT from Streptomyces coelicolor (855 aa); FT P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from FT Haemophilus influenzae (393 aa), FASTA scores: opt: 265, FT E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N- FT and C-termini respectively show similarity to O32735 ATTF FT PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity FT in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FT FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0987 exists as a single gene. FT In Mycobacterium bovis, a single base transition (g-a) FT introduces a stop codon that splits Rv0987 into two parts, FT Mb1013 and Mb1014." FT /db_xref="GOA:Q7U0W9" FT /db_xref="InterPro:IPR003838" FT /db_xref="UniProtKB/TrEMBL:Q7U0W9" FT /protein_id="CAD93875.1" FT /translation="MPGNNLVVAFVGLFSVLIALALIAPPLTRFVMLRLAPGLGRLLGP FT IGRMAPRNIVRSLSRTSIAIAALMMAVSLMVGVSISVGSFRQTLANWLEVTLKSDVYVS FT PPTLTSGRPSGNLPVDAVRNISKWPGVRDAVMARYSSVFAPDWGREVELMAVSGDISDG FT KRPYRWIDGNKDTLWPRFLAGKGVMLSEPMVSRQHLQMPPRPITLMTDSGPQTFPVLAV FT FSDYTSDQGVILMDRASYRAHWQDDDVTTMFLFLASGANSGALIDQLQAAFAGREDIVI FT QSTHSVREASMVIFDRSFTITIALQLVATVVAFIGVLSALMSLELDRAHELGVFRAIGM FT TTRQLWKLMFIETGLMGGMAGLMALPTGCILAWILVRIINVRSFGWTLQMHFESAHFLR FT ALLVAVVAALAAGMYPAWRLGRMTIRTAIREE" FT CDS 118567..119727 FT /transl_table=11 FT /gene="Mb1015" FT /locus_tag="Mb1015" FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT /note="Mb1015, -, len: 386 aa. Equivalent to Rv0988, len: FT 386 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 386 aa overlap). Possible conserved FT exported protein, with potential N-terminal signal FT sequence, similar (except in N-terminus) to O32737|L63540 FT ATTH PROTEIN from Agrobacterium tumefaciens (355 aa), FASTA FT scores: opt: 651, E(): 5.7e-33, (33.4% identity in 344 aa FT overlap); and NP_231265.1|NC_002505 conserved hypothetical FT protein from Vibrio cholerae (372 aa)." FT /db_xref="InterPro:IPR018549" FT /db_xref="UniProtKB/TrEMBL:Q7U0W8" FT /protein_id="CAD93876.1" FT /translation="MRKAGLTGVVLVLTLTLVAFWWWQRPRTNAVAADSLVGVLVDENN FT AGYSLATVPGAIRFPRDLGPHYDYQTEWWYYTGNLETADGRLFGYQLTFFRRALAPPGE FT GVAIADASSWRTTQVYMAHFAISDISNRGFDPAEKFSRQALGLAGASSEPYAVWLDDWY FT ARESNNNSVQLFARTQNTVLDLTLTQTLPPILQGNAGLSVKGAQPGNASNYYSLVRQES FT RGTVSVNGDTFMVSGLSWKDHEYMTSALAPEDVGWDWFGLQFYNGTALMLFQIRQADGS FT VTRFSSGTFVAGDGGVIPLESSDFRIKTTDRWTSDQSGATYPIAWEIEIERIGLTLRGA FT ALMANQELRLSRTYWEGAVALEGRYQGMPISGRGYVEMTGYVQRLS" FT CDS complement(119856..120833) FT /transl_table=11 FT /gene="grcC2" FT /locus_tag="Mb1016c" FT /product="PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC2 FT (POLYPRENYL PYROPHOSPHATE SYNTHETASE)" FT /EC_number="2.5.1.-" FT /note="Mb1016c, grcC2, len: 325 aa. Equivalent to Rv0989c, FT len: 325 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 325 aa overlap). Probable grcC2, FT polyprenyl diphosphate synthetase (EC 2.5.1.-), highly FT similar to NP_302483.1|NC_002677 polyprenyl diphosphate FT synthase component from Mycobacterium leprae (330 aa). Also FT similar to others (generally hepta (EC 2.5.1.30) or FT hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to FT heptaprenyl diphosphate synthase component II (menaquinone FT biosynthesis) from Listeria innocua (321 aa); FT NP_371994.1|NC_002758 heptaprenyl diphosphate syntase FT component II from Staphylococcus aureus subsp. aureus Mu50 FT (319 aa); P55785|HEP2_BACST heptaprenyl diphosphate FT synthase component from Bacillus subtilis (323 aa), FASTA FT scores: opt: 496, E(): 1.4e-24, (31.4% identity in 306 aa FT overlap); etc. Also highly similar to Mycobacterium FT tuberculosis proteins e.g. FT Rv0562|grcC1|NP_215076.1|MTCY25D10.41 PROBABLE FT POLYPRENYL-DIPHOSPHATE SYNTHASE (335 aa); Rv3383, Rv3398c, FT Rv2173, etc. SEEMS TO BELONG TO THE FPP/GGPP SYNTHETASES FT FAMILY." FT /db_xref="GOA:Q7U0W7" FT /db_xref="InterPro:IPR000092" FT /db_xref="UniProtKB/TrEMBL:Q7U0W7" FT /protein_id="CAD93877.1" FT /translation="MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHL FT VDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMSRKTP FT SDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPASHI FT DTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAI FT SGDSATLSGADLGQAVHTLPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSP FT GIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHAVSACD" FT CDS complement(120894..121550) FT /transl_table=11 FT /gene="Mb1017c" FT /locus_tag="Mb1017c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1017c, -, len: 218 aa. Equivalent to Rv0990c, len: FT 218 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 218 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR013974" FT /db_xref="UniProtKB/TrEMBL:Q7U0W6" FT /protein_id="CAD93878.1" FT /translation="MAESSLNPSLVSRISAFLRPDWTRTVRARRFAAAGLVMLAGVAAL FT RSNPEDDRAEVVVAAHDLRPGTALTPGDVRLEKRSATTLPDGSQADLDAVVGSTLASPT FT RRGEVLTDVRLLGSRLAESTAGPDARIVPLHLADSALVDLVRVGDVVDVLAAPVTDSPA FT ALRLLATDAIVVLVSAQQKAQAADSDRVVLVALPARLANTVAGAALGQTVTLTLH" FT CDS complement(121623..121955) FT /transl_table=11 FT /gene="Mb1018c" FT /locus_tag="Mb1018c" FT /product="CONSERVED HYPOTHETICAL SERINE RICH PROTEIN" FT /note="Mb1018c, -, len: 110 aa. Equivalent to Rv0991c, len: FT 110 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 110 aa overlap). Conserved hypothetical FT ser-rich protein (especially in C-terminus), highly similar FT to N-terminus of NP_301255.1|NC_002677 conserved FT hypothetical protein (Ser-rich C-terminus) from FT Mycobacterium leprae (99 aa). Also highly similar to FT SCE22.04|AB90971.1|AL355832 hypothetical protein from FT Streptomyces coelicolor (110 aa); and similar to others." FT /db_xref="InterPro:IPR013429" FT /db_xref="UniProtKB/TrEMBL:Q7U0W5" FT /protein_id="CAD93879.1" FT /translation="MPTYSYECTQCANRFDVVQAFTDDALTTCERCSGRLRKLFNAVGV FT VFKGTGFYRTDSRESGKKSKSQTNGSSTSESTKSSGSSGSSGSSESKASGSTEKSTSST FT TAAAAV" FT CDS complement(122029..122622) FT /transl_table=11 FT /gene="Mb1019c" FT /locus_tag="Mb1019c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1019c, -, len: 197 aa. Equivalent to Rv0992c, len: FT 197 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 197 aa overlap). Conserved hypothetical FT protein, equivalent to NP_301256.1|NC_002677 conserved FT hypothetical protein from Mycobacterium leprae (197 aa). FT Also similar, except in N-terminus, to other hypothetical FT proteins and ligases e.g. SCE87.34|CAB59679.1|AL132674 FT hypothetical protein from Streptomyces coelicolor (204 aa); FT NP_461977.1|NC_003197 putative ligase from Salmonella FT typhimurium (182 aa); P09160|YGFA_ECOLI HYPOTHETICAL 21.1 FT kDa PROTEIN from Escherichia coli (182 aa), FASTA scores: FT opt: 191, E(): 1.1e-09, (29.5% identity in 146 aa overlap); FT etc." FT /db_xref="GOA:Q7U0W4" FT /db_xref="InterPro:IPR002698" FT /db_xref="UniProtKB/TrEMBL:Q7U0W4" FT /protein_id="CAD93880.1" FT /translation="MAIASKSALRDQLLAARRRVADDVRAAEARMLRGHLERMVTSDST FT VCAYVPVGGEPGSIEMLDVLLRRAGRVLLPVARTAGGDLPLPLRWGEYRAGGLARARWG FT LLEPPEPWLPEAALAQASLVLVPALAVDRQGVRLGRGRGFYDRSLRCRDPHARLVAVVR FT TVELVDVLPSEPHDVPMTHALTPERGLIALPCGE" FT CDS 122723..123643 FT /transl_table=11 FT /gene="galU" FT /locus_tag="Mb1020" FT /product="PROBABLE UTP--GLUCOSE-1-PHOSPHATE FT URIDYLYLTRANSFERASE GALU (UDP-GLUCOSE PYROPHOSPHORYLASE) FT (UDPGP) (ALPHA-D-GLUCOSYL-1-PHOSPHATE URIDYLYLTRANSFERASE) FT (URIDINE DIPHOSPHOGLUCOSE PYROPHOSPHORYLASE)" FT /EC_number="2.7.7.9" FT /note="Mb1020, galU, len: 306 aa. Equivalent to Rv0993, FT len: 306 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 306 aa overlap). Probable galU, FT UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9), FT equivalent to AL035500|MLCL373_22 putative FT UTP-glucose-1-phosphate uridylyltransferase from FT Mycobacterium leprae (306 aa), FASTA score: (89.7% identity FT in 302 aa overlap). Also highly similar to others e.g. FT AB59678.1|AL132674 UTP-glucose-1-phosphate FT uridylyltransferase from Streptomyces coelicolor (303 aa); FT NP_244519.1|NC_002570 UTP-glucose-1-phosphate FT uridylyltransferase from Bacillus halodurans (297 aa); FT P25520|GALU_ECOLI|B1236|Z2012|ECS17 FT UTP--glucose-1-phosphate uridylyltransferase from FT Escherichia coli strains K12 and O157:H7 (301 aa), FASTA FT scores: opt: 624, E(): 2.4e-33, (38.8% identity in 299 aa FT overlap); etc. BELONGS TO THE PROKARYOTIC UDPGP FAMILY." FT /db_xref="GOA:Q7U0W3" FT /db_xref="InterPro:IPR005835" FT /db_xref="UniProtKB/TrEMBL:Q7U0W3" FT /protein_id="CAD93881.1" FT /translation="MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIEL FT VAAEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKIAMLAKVRRAPALIKV FT ESVVQAEPLGLGHAIGCVEPTLSPDEDAVAVLLPDDLVLPTGVLETMSKVRASRGGTVL FT CAIEVAREEISAYGVFDVEPVPDGDYTDDPNVLKVRGMVEKPKAETAPSRYAAAGRYVL FT DRAIFDALRRIDRGAGGEVQLTDAIALLIAEGHPVHVVVHQGSRHDLGNPGGYLKAAVD FT FALDRDDYGPDLRRWLVARLGLTEQ" FT CDS 123720..125000 FT /transl_table=11 FT /gene="moeA1" FT /locus_tag="Mb1021" FT /product="PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN FT MOEA1" FT /note="Mb1021, moeA1, len: 426 aa. Equivalent to Rv0994, FT len: 426 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 426 aa overlap). Probable moeA1, FT molybdenum cofactor biosynthesis protein, equivalent to FT AL035500|MLCL373_23 putative molybdopterin biosynthesis FT protein from Mycobacterium leprae (424 aa), FASTA score: FT (88.3% identity in 426 aa overlap). Also highly similar to FT many e.g. CAB59677.1|AL132674 molybdopterin biosynthesis FT protein from Streptomyces coelicolor (424 aa); FT NP_385769.1|NC_003047 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS FT PROTEIN from Sinorhizobium meliloti (406 aa); FT P12281|MOEA_ECOLI molybdopterin biosynthesis moea protein FT from Escherichia coli (411 aa), FASTA scores: opt: 519, FT E(): 1.3e-24, (32.3% identity in 402 aa overlap); etc. Also FT similar to MOEA2|Rv0438c|MTV037.02c PROBABLE MOLYBDOPTERIN FT BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (405 FT aa). Note that previously known as moeA." FT /db_xref="GOA:Q7U0W2" FT /db_xref="HSSP:1G8L" FT /db_xref="InterPro:IPR005110" FT /db_xref="UniProtKB/TrEMBL:Q7U0W2" FT /protein_id="CAD93882.1" FT /translation="MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPG FT FDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQ FT PRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAV FT RAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYAL FT AAAGRDAGAEVNRVGIVSNDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSEL FT GEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHP FT MRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEAN FT CLVVVPTGAEQIRTGEIVDVAFLAQHG" FT CDS 125063..125674 FT /transl_table=11 FT /gene="rimJ" FT /locus_tag="Mb1022" FT /product="POSSIBLE RIBOSOMAL-PROTEIN-ALANINE FT ACETYLTRANSFERASE RIMJ (ACETYLATING ENZYME FOR N-TERMINAL FT OF RIBOSOMAL PROTEIN S5)" FT /EC_number="2.3.1.128" FT /note="Mb1022, rimJ, len: 203 aa. Equivalent to Rv0995, FT len: 203 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 203 aa overlap). Possible rimJ, FT ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), FT equivalent to AL035500|MLCL373_24 probable acyltransferase FT from Mycobacterium leprae (218 aa), FASTA scores: (86.0% FT identity in 200 aa overlap). Also similar to others and FT many acyltransferases e.g. BAB69252.1|AB070946 possible FT acyltransferase from Streptomyces avermitilis (156 aa); FT NP_385025.1|NC_003047 PROBABLE RIBOSOMAL-PROTEIN-ALANINE FT ACETYLTRANSFERASE from Sinorhizobium meliloti (203 aa); FT P09454|RIMJ_ECOLI|B1066|Z1703|ECS1444 FT ribosomal-protein-alanine acetyltransferase from FT Escherichia coli strains K12 and O157:H7 (194 aa), FASTA FT scores: opt: 247, E(): 1.5e-10, (26.9% identity in 186 aa FT overlap). SEEMS TO BELONG TO THE ACETYLTRANSFERASE FAMILY, FT RIMJ SUBFAMILY." FT /db_xref="GOA:Q7U0W1" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q7U0W1" FT /protein_id="CAD93883.1" FT /translation="MAVGPLRVSAGVIRLRPVRMRDGVHWSRIRLADRAHLEPWEPSAD FT GEWTVRHTVAAWPAVCSGLRSEARNGRMLPYVIELDGQFCGQLTIGNVTHGALRSAWIG FT YWVPSAATGGGVATGALALGLDHCFGPVMLHRVEATVRPENAASRAVLAKVGFREEGLL FT RRYLEVDRAWRDHLLMAITVEEVYGSVASTLVRAGHASWP" FT CDS 125835..126911 FT /transl_table=11 FT /gene="Mb1023" FT /locus_tag="Mb1023" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb1023, -, len: 358 aa. Equivalent to Rv0996, len: FT 358 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 358 aa overlap). Probable conserved FT transmembrane protein, equivalent to AL035500|MLCL373_25 FT putative membrane protein from Mycobacterium leprae (342 FT aa), FASTA scores: (66.4% identity in 360 aa overlap). FT Contains possible signal sequence and other hydrophobic FT domains." FT /db_xref="GOA:Q7U0W0" FT /db_xref="UniProtKB/TrEMBL:Q7U0W0" FT /protein_id="CAD93884.1" FT /translation="MPSIPQSLLWISLVVLWLFVLVPMLISKRDAVRRTSDVALATRVL FT NGGAGARLLKRGGPAAGHRWGYLPPEGQGDDPDWKPEEDWRDDPVEGGFADVEHDIDED FT QEADDARRRGAVVMKVAAPQTAGADEPDYLDVDVVEEDSEALPVGAGAAVGESADEADA FT EAADGVAGHADPEADPVEYEYEYEYVEDTCGLELEEDDQEAPPTVASGTSRRRRFDTKT FT AAAVSARKYTFRKRALIVMAVILVGSAAAAFELTPVAWWICGSATGVTVLYLAYLRRQT FT RIEEKVRRRRMQRIARARLGVQNTRDREYDVVPSRLRRPGAVVLEIDDEDPIFTHLESA FT APIRNYGWPRDLPRAVGQ" FT tRNA 126962..127034 FT /gene="alaV" FT /locus_tag="alaV" FT /note="alaV, len: 73 nt. Equivalent to alaV, len: 73 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 73 nt overlap). tRNA-Ala, anticodon cgc." FT CDS 127744..128175 FT /transl_table=11 FT /gene="Mb1024" FT /locus_tag="Mb1024" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1024, -, len: 143 aa. Equivalent to Rv0997, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 143 aa overlap). Hypothetical unknown protein, FT equivalent to AAK45276.1 from Mycobacterium tuberculosis FT strain CDC1551 (87 aa) but longer 56 aa." FT /db_xref="UniProtKB/TrEMBL:Q7U0V9" FT /protein_id="CAD93885.1" FT /translation="MAGIAGVDRDPPGWPQHSHLLAGDPERFRHQLQRAETTNSIECFV FT AEWHHAGVAADMTRPWPTVVQGGAGQRRRRDVEPDRKTPVRWMSGQRLSEITWPTTDIE FT HSVGAAEVQRHRGAVPLGSGGDAAGKVEGGRTPQPFVQP" FT CDS 128199..129200 FT /transl_table=11 FT /gene="Mb1025" FT /locus_tag="Mb1025" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1025, -, len: 333 aa. Equivalent to Rv0998, len: FT 333 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 333 aa overlap). Conserved hypothetical FT protein, possibly cyclic nucleotide-dependent protein FT kinase (EC 2.7.-.-), highly similar to FT NP_301261.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (353 aa); and FT AL035500|MLCL373.38|T45457 hypothetical protein from FT Mycobacterium leprae (143 aa), FASTA score: (61.5% identity FT in 143 aa overlap). Also similar to many hypothetical FT proteins and cyclic-NMP-dependent protein kinases FT (generally at C-terminus) e.g. N-terminus of FT SC9B10.09|T35878 hypothetical protein from Streptomyces FT coelicolor (1039 aa); P05987|KAPR_DICDI CAMP-DEPENDENT FT PROTEIN KINASE REGULATORY CHAIN (EC 2.7.1.37) from FT Dictyostelium discoideum (327 aa), FASTA scores: opt: 177, FT E(): 0.00036, (32.0% identity in 122 aa overlap); FT NP_104403.1|NC_002678 hypothetical protein (contains FT similarity to cAMP-dependent protein kinase regulatory FT subunit) from Mesorhizobium loti (151 aa); etc. Contains FT PS00889 Cyclic nucleotide-binding domain signature 2." FT /db_xref="GOA:Q7U0V8" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:Q7U0V8" FT /protein_id="CAD93886.1" FT /translation="MDGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQ FT VLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTT FT IEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLP FT GDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADA FT RFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMR FT TIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG" FT CDS 129218..129976 FT /transl_table=11 FT /gene="Mb1026" FT /locus_tag="Mb1026" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1026, -, len: 252 aa. Equivalent to Rv0999, len: FT 252 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 252 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7U0V7" FT /protein_id="CAD93887.1" FT /translation="MRPPLAPQFAADLLVKTVSTLRSSGAALGRLTTMRKAVLAVGSVC FT WLVGCSSGASSTTASTGDIAKVAEVKSGFGPEYTVTDVTPRAIDPGFFSARKLPDGLSF FT DPANCAQVAAGPQLPTGLQGNMAAVSAEGNGNRFVVIAVETSQPLPAPSPGKDCSKVTF FT SGTQLRGGIEVVDVPHIDGTQTLGVHRVLQAVVGGSARTGELYDYSARFGDYQVIVIAN FT PLVIPGRPVARVDTQRARDLLVQAVAAVRG" FT CDS complement(129982..130599) FT /transl_table=11 FT /gene="Mb1027c" FT /locus_tag="Mb1027c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1027c, -, len: 205 aa. Equivalent to Rv1000c, len: FT 205 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 205 aa overlap). Conserved hypothetical FT protein, equivalent to ML0190|NP_301263.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (205 aa). Also highly similar to FT SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from FT Streptomyces coelicolor (210 aa), FASTA scores: E(): FT 2.1e-45, (56.8% identity); FT 9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein FT described as DNA repair system specific for alkylated DNA FT from Xylella fastidiosa (200 aa), FASTA scores: E(): FT 3.4e-14, (38.55% identity); and similar in C-terminus to FT other hypothetical proteins. Note that replaces original FT Rv1000 predicted on other strand." FT /db_xref="UniProtKB/TrEMBL:Q7U0V6" FT /protein_id="CAD93888.1" FT /translation="MCDKLGGVAIAVQGALFEHNERRQLGDGAFIDIRSGWLTGGEELL FT DALLSTVPWRAERRQMYDRVVDVPRLVSFHDLTIEDPPHPQLARMRRRLNDIYGGELGE FT PFTTAGLCYYRDGSDSVAWHGDTIGRGSTEDTMVAIVSLGATRVFALRPRGRGPSLRLP FT LAHGDLLVMGGSCQRTFEHAVPKTSAPTGPRVSIQFRPRDVR" FT CDS 130636..131844 FT /transl_table=11 FT /gene="arcA" FT /locus_tag="Mb1028" FT /product="PROBABLE ARGININE DEIMINASE ARCA (ADI) (AD) FT (ARGININE DIHYDROLASE)" FT /EC_number="3.5.3.6" FT /note="Mb1028, arcA, len: 402 aa. Equivalent to Rv1001, FT len: 402 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 402 aa overlap). Probable arcA, arginine FT deiminase (EC 3.5.3.6), similar to e.g. ARCA_PSEAE|P13981 FT arginine deiminase (417 aa), fasta scores: opt: 581, E(): FT 1.4e-31, (39.4% identity in 411 aa overlap); also similar FT to SAGP_STRPY|P16962 streptococcal acid glycoprotein (410 FT aa), FASTA scores, opt: 823, E():0, (38.3% identity in 402 FT aa overlap). BELONGS TO THE ARGININE DEIMINASE FAMILY." FT /db_xref="GOA:P63552" FT /db_xref="InterPro:IPR003876" FT /db_xref="UniProtKB/Swiss-Prot:P63552" FT /protein_id="CAD93889.1" FT /translation="MGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPWV FT SRAQDEHDEFAELLASRGAEVLLLSDLLTEALHHSGAARMQGIAAAVDAPRLGLPLAQE FT LSAYLRSLDPGRLAHVLTAGMTFNELPSDTRTDVSLVLRMHHGGDFVIEPLPNLVFTRD FT SSIWIGPRVVIPSLALRARVREASLTDLIYAHHPRFTGVRRAYESRTAPVEGGDVLLLA FT PGVVAVGVGERTTPAGAEALARSLFDDDLAHTVLAVPIAQQRAQMHLDTVCTMVDTDTM FT VMYANVVDTLEAFTIQRTPDGVTIGDAAPFAEAAAKAMGIDKLRVIHTGMDPVVAEREQ FT WDDGNNTLALAPGVVVAYERNVQTNARLQDAGIEVLTIAGSELGTGRGGPRCMSCPAAR FT DPL" FT CDS complement(131879..133390) FT /transl_table=11 FT /gene="Mb1029c" FT /locus_tag="Mb1029c" FT /product="CONSERVED MEMBRANE PROTEIN" FT /note="Mb1029c, -, len: 503 aa. Equivalent to Rv1002c, len: FT 503 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 503 aa overlap). Conserved membrane FT protein. Similar to AL132674|SCE87.05 hypothetical protein FT from Streptomyces coelicolor (591 aa), FASTA scores: opt: FT 666, E(): 0, (39.0% identity in 546 aa overlap); weakly FT similar to TSCC_PSEAM|P55019 thiazide-sensitive FT sodium-chloride cotransporter from Pseudopleuronectes FT americanus (1023 aa), FASTA scores: opt: 44, E(): 4.2e-06, FT (22.4% identity in 326 aa overlap)." FT /db_xref="GOA:Q7U0V5" FT /db_xref="InterPro:IPR003342" FT /db_xref="UniProtKB/TrEMBL:Q7U0V5" FT /protein_id="CAD93890.1" FT /translation="MVPVVSPGPLVPVADFGPLDRLRGWIVTGLITLLATVTRFLNLGS FT LTDAGTPIFDEKHYAPQAWQVLNNHGVEDNPGYGLVVHPPVGKQLIAIGEAIFGYNGFG FT WRFTGALLGVLLVALVVRIVRRISRSTLVGAIAGVLLICDGVSFVTARTALLDGFLTFF FT VVAAFGALIVDRDQVRERMHIALLAGRSAATVWGPRVGVRWWRFGAGVLLGLACATKWS FT GVYFVLFFGAMALAFDVAARRQYQVQRPWLGTVRRDVLPSGYALGLIPFAVYLATYAPW FT FASETAIDRHAVGQAVGRNSVVPLPDAVRSLWHYTAKAFHFHAGLTNSAGNYHPWESKP FT WTWPMSLRPVLYAIDQQDVAGCGAQSCVKAEMLVGTPAMWWLAVPVLAYAGWRMFVRRD FT WRYAVVLVGYCAGWLPWFADIDRQMYFFYAATMAPFLVMGISLVLGDILYHPGQGSERR FT TLGLIVVCCYVALVVTNFAWLYPVLTGLPISQQTWNLEIWLPSWR" FT CDS 133473..134330 FT /transl_table=11 FT /gene="Mb1030" FT /locus_tag="Mb1030" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1030, -, len: 285 aa. Equivalent to Rv1003, len: FT 285 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 285 aa overlap). Conserved hypothetical FT protein, similar to others e.g. AL132674|SCE87.04 FT Streptomyces coelicolor (286 aa), FASTA scores: opt: 877, FT E(): 0, (53.2% identity in 280 aa overlap); and FT YRAL_ECOLI|P45528 hypothetical 31.3 kd protein (286 aa), FT FASTA scores: opt: 561, E(): 4.4e-27, (36.9% identity in FT 279 aa overlap)." FT /db_xref="GOA:P0A641" FT /db_xref="InterPro:IPR018063" FT /db_xref="UniProtKB/Swiss-Prot:P0A641" FT /protein_id="CAD93891.1" FT /translation="MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLA FT KALDIRIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLVAACI FT DAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWLAELAEERRTCVFF FT ESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVVRGSLDELAIWAAGGVLGEITVV FT VAGAAPHAELSSLIAQVEEFVAAGIRVKDACSEVAAAHPGVRTRQLYDAVLQSRRETGG FT PAQP" FT CDS complement(134340..135599) FT /transl_table=11 FT /gene="Mb1031c" FT /locus_tag="Mb1031c" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb1031c, -, len: 419 aa. Equivalent to Rv1004c, len: FT 419 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 419 aa overlap). Probable membrane protein. FT Contains repetitive sequences, which have similarities with FT elastin, and possible N-terminal signal sequence." FT /db_xref="UniProtKB/TrEMBL:Q7U0V4" FT /protein_id="CAD93892.1" FT /translation="MSISCRVREGFVMRLAIVGTAAAAAIGGTLAVAPLTLSTPERVAG FT GTCSAGQQCDRLAAVLMPDTATPSGPAAAEHAVPAPFEPVADTIAPGLVPRPGVPAAAA FT VPRVGPPAVPGLPNIPGAAGPALPPPPALPNLAAPSVPGVGIPGIGIPGIGIPGIGIPG FT VPDPITGVNTAAAVVNGVLGVGGTAAGVVTASAVAVTYLVLAVNALESSGILPTARGTA FT STVASLLLPGAQSAAAALPAVGLPALPGVTPASLLAMAAAAGLPGVGFPSLPGVSPTDL FT MAMAAAAGLPTSLPGLAGMSPAELTALVAGGLPMLAAAGLPAGLAGVDPATLAAALPAL FT AAGGLPPGLPALPGVDPAALAAALPALAAGLPALPAGLPPLPAVPALPAPPPLPGPPPL FT PALPSRLCTPGFGPIGVCIP" FT CDS complement(135673..137109) FT /transl_table=11 FT /gene="pabB" FT /locus_tag="Mb1032c" FT /product="Probable para-aminobenzoate synthase component I FT PABD" FT /EC_number="4.1.3.-" FT /note="Mb1032c, pabB, len: 478 aa. Similar to Rv1005c, len: FT 458 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 457 aa overlap). Probable PabD, FT para-aminobenzoate synthase component I (EC 4.1.3.-). FT Similar to PABB_ECOLI|P05041 para-aminobenzoate synthase FT component I from Escherichia coli (453 aa), FASTA scores: FT opt: 589, E(): 1.8e-27, (40.7% identity in 268 aa overlap). FT Similar to Mycobacterium tuberculosis Rv1609, Rv3215, FT Rv2386c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a single base transition (g-a) leads to a longer FT product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (478 aa versus 458 aa)." FT /db_xref="GOA:Q7VF03" FT /db_xref="HSSP:1K0G" FT /db_xref="InterPro:IPR019999" FT /db_xref="UniProtKB/TrEMBL:Q7VF03" FT /protein_id="CAD93893.1" FT /translation="MALAARTATPPGTETGAGHGSNLAWELSTRTKSPRSHLRCENPQF FT CQARTVRIDRLGDLGGAPAVLRAVGRATSRLDLPPPAALTGEWFGALAVIAPSVSIQPV FT SGDDVFSGPPGTGGPDATGAVGGGWVGYLSYPDAGADGRPHRIPEAAGGWTDCVLRRDR FT DGQWWYESLSGAPIADWLASALATTRASVARPAPACRIDWEPADRAAHRDGVLACLEAI FT GAGEVYQACVCTQFAGTVTGSPLDFFIDGFGRTAPSRSAFVAGPWGAVASLSPELFLRR FT RGSVVTSSPIKGTLPLDAPPSALRASAKEVAENIMIVDLVRNDLGRVAVTGTVTVPELL FT VVRPAPGVWHLVSTVSARVPLEEPMSALLDAAFPPASVTGTPKLRARQLISQWERYRRG FT IYCGTVGLASPVAGCELNVAIRTVEFDTAGNAVLGVGGGITADSDPDAEWAECLHKAAP FT IVGLPAATRTTPARLASKVR" FT CDS 137165..138868 FT /transl_table=11 FT /gene="Mb1033" FT /locus_tag="Mb1033" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1033, -, len: 567 aa. Equivalent to Rv1006, len: FT 567 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 567 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U0V3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93894.1" FT /translation="MVLRSRKSTLGVVVCLALVLGGPLSGCSSSASHRGPLNAMGSPAI FT PSTAQEIPNPLRGQYEDLMEPLFPQGNPAQQRYPPWPASYDASLRVSWRQLQPTDPRTL FT PPDAPDDRKYDFSVIDNALTRLADRGMRLTLRVYAYSSCCKASYPDGTNIAIPDWERAI FT ASTNTSYPGPATDPSTGVVQVVPNFNDSTYLNDFAQLLAALGRRYDGDERLSVFEFSGY FT GDFSENHVAYLRDTLGAPGPGPDESVATLGYYSQFRDQNITTASIKQLIAANVSAFPHT FT QLVTSPANPEIVRELFADEVTNKLAAPVGVRSDCLGVDAPLPAWAESSTSHYVQTKDPV FT VAALRQRLATAPVITEWCELPTGSSPRAYYEKGLRDVIRYHVSMTSSVNFPDQTATSPM FT DPALYLVWAQANAAAGYRYSVEAQPGSQALAGKVATISVTWTNYGAAAATEKWVPGYRL FT VDSTGQVVRTLPAAVDLKTLVSDQRGDRSSDQPTPASVAETVRVDLSGLPAGHYTLRAA FT IDWQQHKPNGSHVVNYPSMLLSRDGRDDSGFYPVATLDIPRDAQTAVNAS" FT CDS complement(138895..140454) FT /transl_table=11 FT /gene="metS" FT /locus_tag="Mb1034c" FT /product="PROBABLE METHIONYL-TRNA SYNTHETASE METS (MetRS) FT (Methionine--tRNA ligase)" FT /EC_number="6.1.1.10" FT /note="Mb1034c, metS, len: 519 aa. Equivalent to Rv1007c, FT len: 519 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 519 aa overlap). Probable metS (MetG), FT methionyl-tRNA synthetase (EC 6.1.1.10), similar to many FT e.g. SYM_BACSU|P37465 methionyl-tRNA synthetase from FT Bacillus subtilus (664 aa), FASTA scores: opt: 1506, E(): FT 0, (44.9% identity in 492 aa overlap); similar to other M. FT tuberculosis tRNA synthases e.g. Rv2448c, Rv1536, Rv0041. FT Contains PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FT FAMILY. STRONG, TO CYSTEINYL-TRNA SYNTHETASE." FT /db_xref="GOA:P59952" FT /db_xref="InterPro:IPR014758" FT /db_xref="UniProtKB/Swiss-Prot:P59952" FT /protein_id="CAD93895.1" FT /translation="MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDGYDVRFL FT TGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASK FT ELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYF FT FRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPD FT HVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGI FT ELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSD FT EAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVR FT GHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRI FT AALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPE FT GK" FT CDS 140540..141334 FT /transl_table=11 FT /gene="tatD" FT /locus_tag="Mb1035" FT /product="Probable deoxyribonuclease TatD (YjjV protein)" FT /EC_number="3.1.21.-" FT /note="Mb1035, tatD, len: 264 aa. Equivalent to Rv1008, FT len: 264 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 264 aa overlap). Probable tatD FT (alternate gene name: yjjV), deoxyribonuclease (EC FT 3.1.21.-), component of twin arginine translocation protein FT export system (see citation below for more information). FT Similar to many members of the YBL055C/YJJV family e.g. FT YCFH_ECOLI|P37346 Putative deoxyribonuclease ycfH (EC FT 3.1.21.-) (265 aa), fasta scores: opt: 487, E(): 1.4e-24, FT (36.7% identity in 270 aa overlap). Also similar to FT P37545|YABD_BACSU Putative deoxyribonuclease yabD (255 aa), FT FASTA scores: opt: 599, E(): 7.7e-33, (40.1% identity in FT 262 aa overlap). Contains PS01137 Hypothetical YBL055c/yjjV FT family signature 1, and PS01091 Hypothetical YBL055c/yjjV FT family signature 3." FT /db_xref="GOA:Q7VF02" FT /db_xref="HSSP:1J6O" FT /db_xref="InterPro:IPR015992" FT /db_xref="UniProtKB/TrEMBL:Q7VF02" FT /protein_id="CAD93896.1" FT /translation="MVDAHTHLDACGARDADTVRSLVERAAAAGVTAVVTVADDLESAR FT WVTRAAEWDRRVYAAVALHPTRADALTDAARAELERLVAHPRVVAVGETGIDMYWPGRL FT DGCAEPHVQREAFAWHIDLAKRTGKPLMIHNRQADRDVLDVLRAEGAPDTVILHCFSSD FT AAMARTCVDAGWLLSLSGTVSFRNARELREAVPLMPVEQLLVETDAPYLTPHPHRGLAN FT EPYCLPYTVRALAELVNRRPEEVALITTSNARRAYGLGWMRQ" FT CDS 141542..142630 FT /transl_table=11 FT /gene="rpfB" FT /locus_tag="Mb1036" FT /product="Probable resuscitation-promoting factor rpfB" FT /note="Mb1036, rpfB, len: 362 aa. Equivalent to Rv1009, FT len: 362 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 362 aa overlap). Probable rpfB, FT resuscitation-promoting factor (see citation below), FT similar to others from Mycobacterium tuberculosis: FT Rv2450c|MTV008.06c|RPFE PROBABLE RESUSCITATION-PROMOTING FT FACTOR (172 aa), FASTA scores: E(): 1.9e-19, (42.9% FT identity in 147 aa overlap); Rv0867c|RPFA, Rv1884c|RPFC, FT and Rv2389c|RPFD. Possible lipoprotein; contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q7VF01" FT /db_xref="InterPro:IPR010618" FT /db_xref="UniProtKB/TrEMBL:Q7VF01" FT /protein_id="CAD93897.1" FT /translation="MLRLVVGALLLVLAFAGGYAVAACKTVTLTVDGTAMRVTTMKSRV FT IDIVEENGFSVDDRDDLYPAAGVQVHDADTIVLRRSRPLQISLDGHDAKQVWTTASTVD FT EALAQLAMTDTAPAAASRASRVPLSGMALPVVSAKTVQLNDGGLVRTVHLPAPNVAGLL FT SAAGVPLLQSDHVVPAATAPIVEGMQIQVTRNRIKKVTERLPLPPNARRVEDPEMNMSR FT EVVEDPGVPGTQDVTFAVAEVNGVETGRLPVANVVVTPAHEAVVRVGTKPGTEVPPVID FT ESIWDAIAGCEAGGNWAINTGNGYYGGVQFDQGTWEANGGLRYAPRADLATREEQIAVA FT EVTRLRQGWGAWPVCAVRAGAR" FT CDS 142603..143556 FT /transl_table=11 FT /gene="ksgA" FT /locus_tag="Mb1037" FT /product="PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA FT (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) FT dimethyltransferase) (16S rRNA dimethylase) (High level FT kasugamycin resistance protein ksgA) (Kasugamycin FT dimethyltransferase)" FT /EC_number="2.1.1.-" FT /note="Mb1037, ksgA, len: 317 aa. Equivalent to Rv1010, FT len: 317 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 317 aa overlap). Probable ksgA, FT dimethyladenosine transferase (EC 2.1.1.-), similar to many FT e.g. KSGA_BACSU|P37468 dimethyladenosine transferase from FT Bacillus subtilus (292 aa), FASTA scores: opt: 524, E(): FT 1.5e-28, (37.2% identity in 274 aa overlap); similar to FT Mycobacterium tuberculosis hypothetical protein Rv1988. FT Contains PS01131 Ribosomal RNA adenine dimethylases FT signature." FT /db_xref="GOA:P66661" FT /db_xref="InterPro:IPR011530" FT /db_xref="UniProtKB/Swiss-Prot:P66661" FT /protein_id="CAD93898.1" FT /translation="MCCTSGCALTIRLLGRTEIRRLAKELDFRPRKSLGQNFVHDANTV FT RRVVAASGVSRSDLVLEVGPGLGSLTLALLDRGATVTAVEIDPLLASRLQQTVAEHSHS FT EVHRLTVVNRDVLALRREDLAAAPTAVVANLPYNVAVPALLHLLVEFPSIRVVTVMVQA FT EVAERLAAEPGSKEYGVPSVKLRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYETSP FT WPTDDAFRRRVFELVDIAFAQRRKTSRNAFVQWAGSGSESANRLLAASIDPARRGETLS FT IDDFVRLLRRSGGSDEATSTGRDARAPDISGHASAS" FT CDS 143642..144562 FT /transl_table=11 FT /gene="ispE" FT /locus_tag="Mb1038" FT /product="Probable FT 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ISPE FT (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol FT kinase)" FT /EC_number="2.7.1.-" FT /note="Mb1038, ispE, len: 306 aa. Equivalent to Rv1011, FT len: 306 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 306 aa overlap). Probable ispE, FT 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC FT 2.7.1.-), similar to others e.g. Q9K3R6|ISPE_STRCO FT Streptomyces coelicolor (299 aa), FASTA scores: opt: 925, FT E(): 2.7e-49, (54.5% identity in 297 overlap); etc. BELONGS FT TO THE ISPE FAMILY." FT /db_xref="GOA:P65179" FT /db_xref="InterPro:IPR014721" FT /db_xref="UniProtKB/Swiss-Prot:P65179" FT /protein_id="CAD93899.1" FT /translation="MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVT FT VRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMA FT GGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVL FT SRNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLL FT GNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGA FT GVCRTVRVATGPVPGARVVSAPTEV" FT CDS 144559..144873 FT /transl_table=11 FT /gene="Mb1040" FT /locus_tag="Mb1040" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1040, -, len: 104 aa. Equivalent to the 3' end of FT Rv1012, len: 97 aa, from Mycobacterium tuberculosis strain FT H37Rv, (98.4% identity in 63 aa overlap). Hypothetical FT unknown protein. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base insertion (*-g) leads to a different NH2 FT terminus." FT /db_xref="UniProtKB/TrEMBL:Q7U0V2" FT /protein_id="CAD93900.1" FT /translation="MTEFLGACLGRPGVSARAEAGGSIGWRTSMPAVGPQASALAEVGG FT AHQSQAQKPYHDATEPLGENLRYRPAHGDSCINGHRDNPSARESSQFTAGSTAKAVTKL FT " FT CDS 145077..146711 FT /transl_table=11 FT /gene="pks16" FT /locus_tag="Mb1041" FT /product="PUTATIVE POLYKETIDE SYNTHASE PKS16" FT /note="Mb1041, pks16, len: 544 aa. Equivalent to Rv1013, FT len: 544 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 544 aa overlap). Putative pks16, FT polyketide synthase, similar to many e.g. N-terminus of FT Q50857|U24657 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa), FASTA FT scores: opt: 526, E(): 1.4e-25, (29.3% identity in 542 aa FT overlap); etc. Contains PS00455 Putative AMP-binding domain FT signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FT FAMILY." FT /db_xref="GOA:Q7U0V1" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U0V1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93901.1" FT /translation="MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGG FT LAAAGVGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAEDTMTVI FT GMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEVGEDDLALMQLTSGS FT TGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVSWLPCFHDMGMVGFLTIPMFFGAE FT LVKVTPMDFLRDTLLWAKLIDKYQGTMTAAPNFAYALLAKRLRRQAKPGDFDLSTLRFA FT LSGAEPVEPADVEDLLDAGKPFGLRPSAILPAYGMAETTLAVSFSECNAGLVVDEVDAD FT LLAALRRAVPATKGNTRRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESLTPG FT YLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNIYPTDIERAAGR FT VDGVRPGCAVAVRLDAGHSRESFAVAVESNAFEDPAEVRRIEHQVAHEVVAEVDVRPRN FT VVVLGPGTIPKTPSGKLRRANSVTLVT" FT CDS complement(146785..147360) FT /transl_table=11 FT /gene="pth" FT /locus_tag="Mb1042c" FT /product="PROBABLE PEPTIDYL-TRNA HYDROLASE PTH" FT /EC_number="3.1.1.29" FT /note="Mb1042c, pth, len: 191 aa. Equivalent to Rv1014c, FT len: 191 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 191 aa overlap). Probable pth, FT peptidyl-tRNA hydrolase (EC 3.1.1.29), similar to FT PTH_ECOLI|P23932 peptidy l-trna hydrolase from Escherichia FT coli (194 aa), FASTA scores: opt: 472, E(): 2.3e-25, (39.6% FT identity in 187 aa overlap). BELONGS TO THE PTH FAMILY." FT /db_xref="GOA:P65866" FT /db_xref="HSSP:2PTH" FT /db_xref="InterPro:IPR018171" FT /db_xref="UniProtKB/Swiss-Prot:P65866" FT /protein_id="CAD93902.1" FT /translation="MAEPLLVVGLGNPGANYARTRHNLGFVVADLLAARLGAKFKAHKR FT SGAEVATGRSAGRSLVLAKPRCYMNESGRQIGPLAKFYSVAPANIIVIHDDLDLEFGRI FT RLKIGGGEGGHNGLRSVVAALGTKDFQRVRIGIGRPPGRKDPAAFVLENFTPAERAEVP FT TICEQAADATELLIEQGMEPAQNRVHAW" FT CDS complement(147373..148020) FT /transl_table=11 FT /gene="rplY" FT /locus_tag="Mb1043c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L25 RPLY" FT /note="Mb1043c, rplY, len: 215 aa. Equivalent to Rv1015c, FT len: 215 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 215 aa overlap). Probable rplY, 50s FT ribosomal protein L25, similar to RL25_ECOLI|P02426 50s FT ribosomal protein L25 from Escherichia coli (94 aa), FASTA FT scores: opt: 182, E(): 2.5e-05, (38.4% identity in 86 aa FT overlap) and to CTC_BACSU|P14194 general stress protein FT from Bacillus subtilis (203 aa), FASTA scores: opt: 260, FT E(): 1.4e-09, (28.4% identity in 201 aa overlap). BELONGS FT TO THE L25P FAMILY OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66122" FT /db_xref="HSSP:1DFU" FT /db_xref="InterPro:IPR020055" FT /db_xref="UniProtKB/Swiss-Prot:P66122" FT /protein_id="CAD93903.1" FT /translation="MAKSASNQLRVTVRTETGKGASRRARRAGKIPAVLYGHGAEPQHL FT ELPGHDYAAVLRHSGTNAVLTLDIAGKEQLALTKALHIHPIRRTIQHADLLVVRRGEKV FT VVEVSVVVEGQAGPDTLVTQETNSIEIEAEALSIPEQLTVSIEGAEPGTQLTAGQIALP FT AGVSLISDPDLLVVNVVKAPTAEELEGEVAGAEEAEEAAVEAGEAEAAGESE" FT CDS complement(148154..148912) FT /transl_table=11 FT /gene="lpqT" FT /locus_tag="Mb1044c" FT /product="PUTATIVE CONSERVED LIPOPROTEIN LPQT" FT /note="Mb1044c, lpqT, len: 252 aa. Equivalent to 5' end of FT Rv1016c, len: 226 aa, from Mycobacterium tuberculosis FT strain H37Rv, (98.9% identity in 190 aa overlap). Probable FT lpqT, conserved lipoprotein. Similar to several M. FT tuberculosis hypothetical proteins e.g. FT Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA antigen (310 FT aa), FASTA scores: opt: 329, E(): 2e-17, (32.3% identity in FT 229 aa overlap); Rv0583c. Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT frameshift due to a 5 bp deletion (cacgc-*) leads to a FT longer product with a different COOH part compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv." FT /db_xref="GOA:Q7U0V0" FT /db_xref="InterPro:IPR019674" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0V0" FT /protein_id="CAD93904.1" FT /translation="MAGRRCPQDSVRPLAVAVAVATLAMSAVACGPKSPDFQSILSTSP FT TTSAVSTTTEVPVPLWKYLESVGVTGEPVAPSSLTDLTVSIPTPPGWAPMKNPNITPNT FT EMIAKGESYPTAMLMVFKLHRDFDIAEALKHGTADARLSTNFTELDSSTADFNGFPSSM FT IQGSYDLHGRRLHTWNRIVFPTGAGQAALPGAAHHHESGQRGRQARFRHRGDHRRIRRR FT GKVIVRTVGAQLSEQLTRIEFPQCSSHGLA" FT CDS complement(148948..149928) FT /transl_table=11 FT /gene="prsA" FT /locus_tag="Mb1045c" FT /product="PROBABLE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE PRSA FT (Phosphoribosyl pyrophosphate synthetase) (PRPP FT synthetase)" FT /EC_number="2.7.6.1" FT /note="Mb1045c, prsA, len: 326 aa. Equivalent to Rv1017c, FT len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 326 aa overlap). Probable prsA, FT ribose-phosphate pyrophosphokinase (EC 2.7.6.1), highly FT similar to others e.g. KPRS_ECOLI|P08330 ribose-phosphate FT pyrophosphokinase from Escherichia coli (314 aa), FASTA FT scores: opt: 826, E(): 0, (43.8% identity in 317 aa FT overlap). Contains PS00103 Purine/pyrimidine phosphoribosyl FT transferases signature; contains PS00144 Asparaginase / FT glutaminase active site signature 1. BELONGS TO THE FT RIBOSE-PHOSPHATE PYROPHOSPHOKINASE FAMILY. COFACTOR: BOTH FT INORGANIC PHOSPHATE AND MAGNESIUM ION ARE REQUIRED FOR FT ENZYME STABILITY AND ACTIVITY (by similarity)." FT /db_xref="GOA:P65233" FT /db_xref="HSSP:1DKR" FT /db_xref="InterPro:IPR005946" FT /db_xref="UniProtKB/Swiss-Prot:P65233" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93905.1" FT /translation="MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFAN FT GEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPYAR FT QDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYI FT RDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVA FT GRTCVLIDDMIDTGGTIAGAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIV FT TNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTGLFDGDA" FT CDS complement(150020..151507) FT /transl_table=11 FT /gene="glmU" FT /locus_tag="Mb1046c" FT /product="Probable UDP-N-acetylglucosamine FT pyrophosphorylase glmU" FT /EC_number="2.7.7.23" FT /note="Mb1046c, glmU, len: 495 aa. Equivalent to Rv1018c, FT len: 495 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 495 aa overlap). Probable glmU, FT UDP-n-acetylglucosamine pyrophosphorylase (EC 2.7.7.23), FT similar to GCAD_BACSU|P14192 UDP-n-acetylglucosamine FT pyrophosphorylase (456 aa), FASTA scores: opt: 1150, E(): FT 0, (40.0% identity in 453 aa overlap). Similar to various FT Mycobacterium tuberculosis sugar-phosphate transferases FT e.g. Rv0334, Rv1213, Rv3264c, etc." FT /db_xref="GOA:Q7VF00" FT /db_xref="HSSP:1HM9" FT /db_xref="InterPro:IPR005882" FT /db_xref="UniProtKB/Swiss-Prot:Q7VF00" FT /protein_id="CAD93906.1" FT /translation="MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIA FT KLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDY FT AGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHGVMA FT IVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQ FT TVHASHVDDSALVAGVNNRVQLAQLASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIG FT RDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPF FT TYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYD FT GTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIE FT NWVQRKRPGSPAAQASKRASEMACQQPTQPPDADQTP" FT tRNA complement(151523..151594) FT /gene="glnT" FT /locus_tag="glnT" FT /note="glnT, len: 72 nt. Equivalent to glnT, len: 72 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 72 nt overlap). tRNA-Gln, anticodon ttg." FT CDS 151762..152355 FT /transl_table=11 FT /gene="Mb1047" FT /locus_tag="Mb1047" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR-FAMILY)" FT /note="Mb1047, -, len: 197 aa. Equivalent to Rv1019, len: FT 197 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 197 aa overlap). Probable transcriptional FT regulator, similar to many memebers of the tetR family e.g. FT MTCY7D11.18c (34.4% identity in 189 aa overlap). Helix turn FT helix motif from aa 27-48 (+5.42 SD)." FT /db_xref="GOA:Q7U0U9" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7U0U9" FT /protein_id="CAD93907.1" FT /translation="MTGTERRHQLIGIARSLFAERGYDGTSIEEIAQRANVSKPVVYEH FT FGGKEGLYAVVVDREMSALLDGITSSLTNNRSRVRVERVALALLTYVEERTDGFRIMIR FT DSPASISSGTYSSLLNDAVSQVSSILAGDFARRGLDPDLAPLYAQALVGSVSMTAQWWL FT DAREPKKEVVAAHLVNLVWNGLTHLEADPRLQDE" FT CDS 152414..156118 FT /transl_table=11 FT /gene="mfd" FT /locus_tag="Mb1048" FT /product="PROBABLE TRANSCRIPTION-REPAIR COUPLING FACTOR MFD FT (TRCF)" FT /note="Mb1048, mfd, len: 1234 aa. Equivalent to Rv1020, FT len: 1234 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 1234 aa overlap). Probable mfd, FT transcription-repair coupling factor, similar to many e.g. FT MFD_ECOLI|P30958 transcription-repair coupling factor from FT Escherichia coli (1148 aa), FASTA scores: opt: 1900, E(): FT 0, (37.9% identity in 1107 aa overlap). Also similar to M. FT tuberculosis Rv2973c and Rv1633. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). IN THE N-TERMINAL FT SECTION; BELONGS TO THE UVRB FAMILY. IN THE C-TERMINAL FT SECTION; BELONGS TO THE HELICASE FAMILY. RECG SUBFAMILY." FT /db_xref="GOA:P64327" FT /db_xref="HSSP:1D9X" FT /db_xref="InterPro:IPR005118" FT /db_xref="UniProtKB/Swiss-Prot:P64327" FT /protein_id="CAD93908.1" FT /translation="MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAP FT ASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLSPG FT VDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESP FT FDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFS FT VADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLA FT EGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEAS FT WSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVR FT AAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPG FT QAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLA FT LTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSL FT DQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPDT FT PWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAV FT QDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVD FT IVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLE FT MSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLRDGQAFYVHNRVSSID FT AAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILVCTTIVETGLDISNANT FT LIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGA FT GMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVR FT TAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGAL FT PEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRA FT TTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAGKPRQHIGITNPSPPGEDGRGR FT NTTIKERQP" FT CDS 156118..157095 FT /transl_table=11 FT /gene="Mb1049" FT /locus_tag="Mb1049" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1049, -, len: 325 aa. Equivalent to Rv1021, len: FT 325 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 325 aa overlap). Conserved hypothetical FT protein, similar to YBL1_STRCI|P33653 hypothetical 26.1 kd FT protein from Streptomyces cacaoi (242 aa), FASTA scores: FT opt: 493, E(): 1.1e-23, (42.9% identity in 238 aa FT overlap)." FT /db_xref="InterPro:IPR004518" FT /db_xref="UniProtKB/TrEMBL:Q7U0U8" FT /protein_id="CAD93909.1" FT /translation="MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARS FT AHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWE FT SEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTI FT DDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALAL FT AQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVAR FT RGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR" FT CDS 157183..157914 FT /transl_table=11 FT /gene="lpqU" FT /locus_tag="Mb1050" FT /product="PUTATIVE CONSERVED LIPOPROTEIN LPQU" FT /note="Mb1050, lpqU, len: 243 aa. Equivalent to Rv1022, FT len: 243 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 243 aa overlap). Probable lpqU conserved FT lipoprotein. Similar to Mycobacterium tuberculosis FT hypothetical protein Rv1230c|MTV006.02C, FASTA scores: E(): FT 2.8e-18, (37.9% identity in 240 aa overlap). Similar to FT AL133423|SC4A7.37 hypothetical protein from Streptomyces FT coelicolor (421 aa), FASTA scores: opt: 474, E(): 2.7e-21, FT (42.2% identity in 211 aa overlap). Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="UniProtKB/TrEMBL:Q7U0U7" FT /protein_id="CAD93910.1" FT /translation="MSPRRWLRAVAVIGATAMLLASSCTWQLSLFIPDGVPPPPGDPVP FT PVDTHAGGRPADQLREWAEKRAAALGIPVIALEAYAYAARVAEVENPKCHLAWTTLAGI FT GRVESHHGTYRGATIAPNGDVSPPIRGVRLDGTGGTLRIVDRDGGGLDGDAAVERAMGP FT MQFISETWRLYGVAARNDGIANVDNIDDAALSAAGYLCWRGKDLATPRGWITALRAYNN FT SVIYARAVRDWATAYAAGHPL" FT CDS 158011..159300 FT /transl_table=11 FT /gene="eno" FT /locus_tag="Mb1051" FT /product="PROBABLE ENOLASE ENO" FT /EC_number="4.2.1.11" FT /note="Mb1051, eno, len: 429 aa. Equivalent to Rv1023, len: FT 429 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 429 aa overlap). Probable eno, enolase FT (EC 4.2.1.11), highly similar to others e.g. FT ENO_ECOLI|P08324 enolase from Escherichia coli (431 aa), FT FASTA scores: opt: 1487, E(): 0, (55.5% identity in 422 aa FT overlap); etc. MAGNESIUM IS REQUIRED FOR CATALYSIS AND FOR FT STABILIZING THE DIMER. BELONGS TO THE ENOLASE FAMILY." FT /db_xref="GOA:Q7U0U6" FT /db_xref="HSSP:1E9I" FT /db_xref="InterPro:IPR000941" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0U6" FT /protein_id="CAD93911.1" FT /translation="MPIIEQVGAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGE FT HEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSR FT LGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDIQE FT FMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLIS FT RAIESAGLRPGADVALALDAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVS FT IEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERLEEGIERGVANALLVKVNQIG FT TLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKY FT NQLLRIEEALGDAARYAGDLAFPRFACETK" FT CDS 159305..159991 FT /transl_table=11 FT /gene="Mb1052" FT /locus_tag="Mb1052" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1052, -, len: 228 aa. Equivalent to Rv1024, len: FT 228 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 228 aa overlap). Hypothetical unknown protein, FT hydrophobic region from aa 83-101." FT /db_xref="GOA:Q7U0U5" FT /db_xref="InterPro:IPR007060" FT /db_xref="UniProtKB/TrEMBL:Q7U0U5" FT /protein_id="CAD93912.1" FT /translation="MPEAKRPESKRRSPASRPGKAGDSVRGGRATKPSAKPSTPAPHAS FT RKTTRTPHEHIVEPIKRAITESVEKRSEQRLGFTARRAAILAAVVCVLTLTIARPVRTY FT FAQRAEMEQLAATEAMLRRQIADLEEQQVKLADPAYIAAQARERLGFVMPGDIPFQVQL FT PSTPLAPPQPGSDAATATNNEPWYTALWHTIADDPHLPPAAPPAPEPGRPGPLPPASPN FT PEQPGG" FT CDS 160008..160475 FT /transl_table=11 FT /gene="Mb1053" FT /locus_tag="Mb1053" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1053, -, len: 155 aa. Equivalent to Rv1025, len: FT 155 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 155 aa overlap). Conserved hypothetical FT protein, similar to AE001768|AE001768_4 hypothetical FT protein from Thermotoga maritima (170 aa), FASTA scores: FT opt: 254, E(): 9.5e-10, (35.7% identity in 143 aa FT overlap)." FT /db_xref="InterPro:IPR007511" FT /db_xref="UniProtKB/TrEMBL:Q7U0U4" FT /protein_id="CAD93913.1" FT /translation="MVTRQLGRAPRGVLAIAYRCPNGEPGVVKTAPRLPDGTPFPTLYY FT LTHPVLTAAASRLETTGLMREMNRRLGQDAELAAAYRRAHESYLSERDALEPLGTTVSA FT GGMPDRVKCLHVLIAHSLAKGPGLNPFGDEALALLAAEPRTAATLVAGQWR" FT CDS 160466..161425 FT /transl_table=11 FT /gene="Mb1054" FT /locus_tag="Mb1054" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1054, -, len: 319 aa. Equivalent to Rv1026, len: FT 319 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 319 aa overlap). Conserved hypothetical FT protein. Equivalent to AL023514|MLCB4.02 hypothetical FT protein from Mycobacterium leprae (317 aa) (77.9% identity FT in 321 aa overlap). Similar to GPPA_ECOLI|P25552 FT guanosine-5'-triphosphate, 3'-diphosphate pyrophoshatase FT from Escherichia coli (494 aa), FASTA scores: opt: 281, FT E(): 3.2e-11, (30.6% identity in 291 aa overlap)." FT /db_xref="InterPro:IPR003695" FT /db_xref="UniProtKB/TrEMBL:Q7U0U3" FT /protein_id="CAD93914.1" FT /translation="MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLG FT QGVDATGRFAPEAIARTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTAD FT VLGAALPGSAAEVITGAEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVA FT SYSADIGCVRLTERCLHSDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTM FT TTLSALAQSMTAYDAAAIHLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGG FT GAIVVEELARELRERAGIDQLTVSEHDILDGIALSLAG" FT CDS complement(161874..162554) FT /transl_table=11 FT /gene="kdpE" FT /locus_tag="Mb1055c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN KDPE" FT /note="Mb1055c, kdpE, len: 226 aa. Equivalent to Rv1027c, FT len: 226 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 226 aa overlap). Probable KdpE, FT transcriptional regulatory protein, similar to others e.g. FT KDPE_ECOLI|P21866 kdp operon transcriptional regulatory FT protein from Escherichia coli strain K12 (225 aa), FASTA FT scores: opt: 691, E(): 0, (47.8% identity in 224 aa FT overlap); AL021530|SC2E9.13 from Streptomyces coelicolor FT (227 aa), FASTA scores: opt: 981, E(): 0, (66.4% identity FT in 226 aa overlap); etc." FT /db_xref="GOA:Q7U0U2" FT /db_xref="HSSP:1B00" FT /db_xref="InterPro:IPR001867" FT /db_xref="UniProtKB/TrEMBL:Q7U0U2" FT /protein_id="CAD93915.1" FT /translation="MTLVLVIDDEPQILRALRINLTVRGYQVITASTGAGALRAAAEHP FT PDVVILDLGLPDMSGIDVLGGLRGWLTAPVIVLSARTDSSDKVQALDAGADDYVTKPFG FT MDEFLARLRAAVRRNTAAAELEQPVIETDSFTVDLAGKKVIKDGAEVHLTPTEWGMLEM FT LARNRGKLVGRGELLKEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGY FT RFEA" FT CDS complement(162551..165133) FT /transl_table=11 FT /gene="kdpD" FT /locus_tag="Mb1056c" FT /product="PROBABLE SENSOR PROTEIN KDPD" FT /EC_number="2.7.3.-" FT /note="Mb1056c, kdpD, len: 860 aa. Equivalent to Rv1028c, FT len: 860 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 860 aa overlap). Probable kdpD, sensor FT protein (EC 2.7.3.-), similar to others e.g. FT KDPD_ECOLI|P21865 sensor protein from Escherichia coli FT strain K12 (894 aa), FASTA scores: opt: 1041, E(): 0, FT (32.3% identity in 888 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7U0U1" FT /db_xref="InterPro:IPR006016" FT /db_xref="UniProtKB/TrEMBL:Q7U0U1" FT /protein_id="CAD93916.1" FT /translation="MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAM FT LGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIEMIPPRYVEYRGARFPELDVEAVLR FT RHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITG FT IEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTAL FT REIALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKS FT SAELMVVHVIRGDDLAGVSAPQLGRVRELATSLGATMHTVVGDDVPTALLDFAREMNAT FT QLVVGTSRRSRWARLFDEGIGARTVQESGGIDVHMVTHPAASRASGWSRVSPRERHIAS FT WLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLL FT NYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVLVDGAASRTREARRASQEAELLALF FT AGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVACVGTNPCRDVDSADTAI FT EVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRS FT LLSAVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESIDQLTALVANLLDS FT SRLAAGVIRPQLRRAYLEEAVQRALVSIGKGATGFYRSGIDRVKVDVGDAVAMADAGLL FT ERVLANLIDNALRYAPDCVVRVNAGRVRERVLINVIDEGPGVPRGTEEQLFAPFQRPGD FT HDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP" FT CDS 165367..165459 FT /transl_table=11 FT /gene="kdpF" FT /locus_tag="Mb1057" FT /product="Probable membrane protein kdpF" FT /note="Mb1057, kdpF, len: 30 aa. Equivalent to Rv1028A, FT len: 30 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 30 aa overlap). Probable kdpF, membrane FT protein, showing similarity with P36937|KDPF_ECOLI|B0698.1 FT PROTEIN KDPF from Escherichia coli strain K12 (see citation FT below) (27% identity); and KdpF protein from Streptomyces FT coelicolor (51% identity)." FT /db_xref="InterPro:IPR011726" FT /db_xref="UniProtKB/TrEMBL:Q7VEZ9" FT /protein_id="CAD93917.1" FT /translation="MTTVDNIVGLVIAVALMAFLFAALLFPEKF" FT CDS 165459..167174 FT /transl_table=11 FT /gene="kdpA" FT /locus_tag="Mb1058" FT /product="Probable Potassium-transporting ATPase A chain FT KDPA (Potassium-translocating ATPase A chain) (ATP FT phosphohydrolase [potassium-transporting] A chain) FT (Potassium binding and translocating subunit A)" FT /EC_number="3.6.3.12" FT /note="Mb1058, kdpA, len: 571 aa. Equivalent to Rv1029, FT len: 571 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 571 aa overlap). Probable kdpA, FT potassium-transporting ATPase A chain (transmembrane FT protein) (EC 3.6.3.12), similar to others e.g. FT ATKA_ECOLI|P03959|KDPA|B0698 potassium-transporting ATPase FT A chain from Escherichia coli strain K12 (557 aa), FASTA FT scores: opt: 1763, E(): 0, (50.4% identity in 569 aa FT overlap); etc. BELONGS TO THE KDPA FAMILY." FT /db_xref="GOA:P65210" FT /db_xref="InterPro:IPR004623" FT /db_xref="UniProtKB/Swiss-Prot:P65210" FT /protein_id="CAD93918.1" FT /translation="MSGTSWLQFAALIAVLLLTAPALGGYLAKIYGDEAKKPGDRVFGP FT IERVIYQVCRVDPGSEQRWSTYALSVLAFSVMSFLLLYGIARFQGVLPFNPTDKPAVTD FT HVAFNAAVSFMTNTNWQSYSGEATMSHFTQMTGLAVQNFVSASAGMCVLAALIRGLARK FT RASTLGNFWVDLARTVLRIMFPLSFVVAILLVSQGVIQNLHGFIVANTLEGAPQLIPGG FT PVASQVAIKQLGTNGGGFFNVNSAHPFENYTPIGNFVENWAILIIPFALCFAFGKMVHD FT RRQGWAVLAIMGIIWIGMSVAAMSFEAKGNPRLDALGVTQQTTVDQSGGNLEGKEVRFG FT VGASGLWAASTTGTSNGSVNSMHDSYTPLGGMVPLAHMMLGEVSPGGTGVGLNGLLVMA FT ILAVFIAGLMVGRTPEYLGKKIQATEMKLVTLYILAMPIALLSFAAASVLISSALASRN FT NPGPHGLSEILYAYTSGANNNGSAFAGLTASTWSYDTTIGVAMLIGRFFLIIPVLAIAG FT SLARKGTTPVTAATFPTHKPLFVGLVIGVVLIVGGLTFFPALALGPIVEQLSTQ" FT CDS 167171..169300 FT /transl_table=11 FT /gene="kdpB" FT /locus_tag="Mb1059" FT /product="Probable Potassium-transporting P-type ATPase B FT chain KDPB (Potassium-translocating ATPase B chain) (ATP FT phosphohydrolase [potassium-transporting] B chain) FT (Potassium binding and translocating subunit B)" FT /EC_number="3.6.3.12" FT /note="Mb1059, kdpB, len: 709 aa. Equivalent to Rv1030, FT len: 709 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 709 aa overlap). Probable kdpB, FT potassium-transporting P-type ATPase B chain (transmembrane FT protein) (EC 3.6.3.12), similar to others e.g. FT ATKB_ECOLI|P03960 potassium-transporting ATPase B chain FT from Escherichia coli strain K12 (682 aa), FASTA scores: FT opt: 1481, E(): 0, (63.4% identity in 686 aa overlap); etc. FT Very similar to AL078610|SCH35.47 H+/K+-exchanging ATPase FT (EC 3.6.1.36) chain B from Streptomyces coelicolor (707 FT aa), FASTA scores: opt: 2731, E(): 0, (71.6% identity in FT 676 aa overlap). Contains PS00154 E1-E2 ATPases FT phosphorylation site." FT /db_xref="GOA:P63682" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:P63682" FT /protein_id="CAD93919.1" FT /translation="MMIARMETSATAAAATSAPRLRLAKRSLFDPMIVRSALPQSLRKL FT APRVQARNPVMLVVLVGAVITTLAFLRDLASSTAQENVFNGLVAAFLWFTVLFANFAEA FT MAEGRGKAQAAALRKVRSETMANRRTAAGNIESVPSSRLDLDDVVEVSAGETIPSDGEI FT IEGIASVDESAITGESAPVIRESGGDRSAVTGGTVVLSDRIVVRITAKQGQTFIDRMIA FT LVEGAARQQTPNEIALNILLAGLTIIFLLAVVTLQPFAIYSGGGQRVVVLVALLVCLIP FT TTIGALLSAIGIAGMDRLVQHNVLATSGRAVEAAGDVNTLLLDKTGTITLGNRQATEFV FT PINGVSAEAVADAAQLSSLADETPEGRSIVVLAKDEFGLRARDEGVMSHARFVPFTAET FT RMSGVDLAEVSGIRRIRKGAAAAVMKWVRDHGGHPTEEVGAIVDGISSGGGTPLVVAEW FT TDNSSARAIGVVHLKDIVKVGIRERFDEMRRMSIRTVMITGDNPATAKAIAQEAGVDDF FT LAEATPEDKLALIKREQQGGRLVAMTGDGTNDAPALAQADVGVAMNTGTQAAREAGNMV FT DLDSDPTKLIEVVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFVGLYPVLDKLNVM FT ALHSPRSAILSAVIFNALVIVALIPLALRGVRFRAESASAMLRRNLLIYGLGGLVVPFI FT GIKLVDLVIVALGVS" FT CDS 169300..169869 FT /transl_table=11 FT /gene="kdpC" FT /locus_tag="Mb1060" FT /product="Probable Potassium-transporting ATPase C chain FT KDPC (Potassium-translocating ATPase C chain) (ATP FT phosphohydrolase [potassium-transporting] C chain) FT (Potassium binding and translocating subunit C)" FT /EC_number="3.6.3.12" FT /note="Mb1060, kdpC, len: 189 aa. Equivalent to Rv1031, FT len: 189 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 189 aa overlap). Probable kdpC, FT potassium-transporting ATPase C chain (membrane protein) FT (EC 3.6.3.12), similar to others e.g. ATKC_ECOLI|P03961 FT potassium-transporting ATPase C chain from Escherichia coli FT strain K12 (190 aa), FASTA scores: opt: 475, E(): 3.1e-24, FT (45.7% identity in 186 aa overlap); etc. BELONGS TO THE FT KDPC FAMILY." FT /db_xref="GOA:P65212" FT /db_xref="InterPro:IPR003820" FT /db_xref="UniProtKB/Swiss-Prot:P65212" FT /protein_id="CAD93920.1" FT /translation="MRRQLLPALTMLLVFTVITGIVYPLAVTGVGQLFFGDQANGALLE FT RDGQVIGSAHIGQQFTAAKYFHPRPSSAGDGYDAAASSGSNLGPTNEKLLAAVAERVTA FT YRKENNLPADTLVPVDAVTGSGSGLDPAISVVNAKLQAPRVAQARNISIRQVERLIEDH FT TDARGLGFLGERAVNVLRLNLALDRL" FT CDS complement(169873..171402) FT /transl_table=11 FT /gene="trcS" FT /locus_tag="Mb1061c" FT /product="TWO COMPONENT SENSOR HISTIDINE KINASE TRCS" FT /EC_number="2.7.3.-" FT /note="Mb1061c, trcS, len: 509 aa. Equivalent to Rv1032c, FT len: 509 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 509 aa overlap). trcS, two component FT sensor histidine kinase protein (EC 2.7.3.-) (see citations FT below), similar to YV16_MYCLE|P54883 probable sensor-like FT histidine kinase from Mycobacterium leprae (443 aa), FASTA FT scores: opt: 392, E(): 3.8e-18, (31.7% identity in 334 aa FT overlap). Note that in vitro autophosphorylation of TrcS FT requires the presence of Mn2+or Ca2+as a divalent cation FT cofactor and subsequent transphosphorylation of TrcR is FT evident in the presence of TrcS-phosphate and Ca2+." FT /db_xref="GOA:Q7U0U0" FT /db_xref="HSSP:1BXD" FT /db_xref="InterPro:IPR003660" FT /db_xref="UniProtKB/TrEMBL:Q7U0U0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93921.1" FT /translation="MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVL FT SLSGYVTAMNDAELVESLHALNHSYTRYRDSAQTSTPTGNLPMSQAVLEFTGQTPGNLI FT AVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAAG FT ADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAE FT VATMPLTDDDHQISVRVRPGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQF FT ITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSR FT LSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNL FT LTNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKS FT RSNGSGHGLGLAIVSSIVKAHRGSVTAESGNGQTVFRVRLPMIEQQIATTA" FT CDS complement(171410..172183) FT /transl_table=11 FT /gene="trcR" FT /locus_tag="Mb1062c" FT /product="TWO COMPONENT TRANSCRIPTIONAL REGULATOR TRCR" FT /note="Mb1062c, trcR, len: 257 aa. Equivalent to Rv1033c, FT len: 257 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 257 aa overlap). trcR, two-component FT regulatory protein (see citations below), similar to Q50825 FT TWO COMPONENT RESPONSE REGULATOR from Mycobacterium FT tuberculosis (234 aa), FASTA scores: opt: 628, E(): 0, FT (46.0% identity in 226 aa overlap). Note that in vitro FT autophosphorylation of TrcS requires the presence of Mn2+or FT Ca2+as a divalent cation cofactor and subsequent FT transphosphorylation of TrcR is evident in the presence of FT TrcS-phosphate and Ca2+." FT /db_xref="GOA:Q7U0T9" FT /db_xref="HSSP:1KGS" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7U0T9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93922.1" FT /translation="MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTN FT LVKMALHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRESDVYT FT PTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRRSSHLERPADEALRV FT GDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNPRRALSRTEILDRVWNYDFAGRTS FT IVDLYISYLRKKIDSDREPMIHTVRGIGYMLRPPE" FT CDS complement(172365..172754) FT /transl_table=11 FT /gene="Mb1063c" FT /locus_tag="Mb1063c" FT /product="PROBABLE TRANSPOSASE (FRAGMENT)" FT /note="Mb1063c, -, len: 129 aa. Equivalent to Rv1034c, len: FT 129 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 129 aa overlap). Probable IS1560 transposase FT fragment, similar to part of Rv3387|E1202305|MTV004.45 (225 FT aa) (65.1% identity in 129 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0T8" FT /protein_id="CAD93923.1" FT /translation="MQQGNPPDAPQLAPAVAWVKKRAGRTPRTVTADRGYGEAAVDQQL FT TEVGVKNVLIPRKGKPSQDRRAEEHRKAFRRTIKWRTGCEGRISHLKRGYGWDRGRIGG FT LEGTRTWVGHGVFAHNLVTISALPA" FT repeat_region complement(172368..173880) FT /mobile_element="insertion sequence:IS1560" FT /locus_tag="IS1560'-1" FT /note="IS1560'-1, len: 1513 nt. Equivalent to IS1560, len: FT 1513 nt, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 1513 nt overlap)." FT CDS complement(172822..173508) FT /transl_table=11 FT /gene="Mb1064c" FT /locus_tag="Mb1064c" FT /product="PROBABLE TRANSPOSASE (FRAGMENT)" FT /note="Mb1064c, -, len: 228 aa. Equivalent to Rv1035c, len: FT 228 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 228 aa overlap). Probable IS1560 transposase FT fragment, similar to parts of Rv3387|E1202305|MTV004.45 FT (225 aa) (47.8% identity in 67 aa overlap) and FT Rv3386|E1202304|MTV004.44 (234 aa) (55.1% identity in 127 FT aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0T7" FT /protein_id="CAD93924.1" FT /translation="MPHPTTLMKLTTRCGSAAIDGLNEALLAKAAEAKLLGTNRIRADT FT TVARANVSYPTDLGLLAKAMRRIAATGKRIQAAGGAVRTRVGDRSRAAGRRAHAVAAKL FT RSRAELGRDEARAAVLRFTGELAELAQAAAQEAQQLLDNAKQAVLRAKAKAAALAARGE FT RDAVAGRRCGGLVRAVNDLTELLNATRQIVAQTRQRVAGITSDGASRRVSLHDGDARPD FT HQGSAR" FT CDS complement(173542..173880) FT /transl_table=11 FT /gene="Mb1065c" FT /locus_tag="Mb1065c" FT /product="PROBABLE IS1560 TRANSPOSASE (FRAGMENT)" FT /note="Mb1065c, -, len: 112 aa. Equivalent to Rv1036c, len: FT 112 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 112 aa overlap). Probable IS1560 transposase FT fragment, similar to part of Rv3386|E1202304|MTV004.44 (234 FT aa) (82.8% identity in 87 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0T6" FT /protein_id="CAD93925.1" FT /translation="MIPGRMVLNWEDGLNALVAEGIEAIVFRTLGDQCWLWESLLPDEV FT RRLPEELARVDALLDDPAFFAPFVPFFDPRRGRPSTPMEVYLQLMFVKFRYRLGYESLC FT REVADSIT" FT CDS complement(173991..174275) FT /transl_table=11 FT /gene="esxI" FT /locus_tag="Mb1066c" FT /standard_name="ES6_1; Mtb9.9D" FT /product="PUTATIVE ESAT-6 LIKE PROTEIN 1" FT /note="Mb1066c, esxI, len: 94 aa. Equivalent to Rv1037c, FT len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.9% identity in 94 aa overlap). esxI, conserved FT hypothetical protein, member of ESAT-6 family, highly FT similar to many Mycobacterial hypothetical proteins e.g. FT Q49946|ES6X_MYCLE|U1756D PUTATIVE ESAT-6 LIKE PROTEIN X FT from Mycobacterium leprae (95 aa), FASTA scores: opt: 409, FT E(): 6.3e-23, (64.15% identity in 92 aa overlap); Rv3619c, FT Rv1198, Rv2346c, etc from Mycobacterium tuberculosis. FT Strictly identical to FT P96364|ES61_MYCTU|Rv3619c|MTCY15C10.33|MTCY07H7B.03|MT3721 FT PUTATIVE ESAT-6 LIKE PROTEIN 1 (94 aa). BELONGS TO THE FT ESAT6 FAMILY." FT /db_xref="InterPro:IPR009416" FT /db_xref="UniProtKB/Swiss-Prot:P59802" FT /protein_id="CAD93926.1" FT /translation="MTINYQFGDVDAHGAMIRALAGSLEAEHQAIISDVLTASDFWGGA FT GSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA" FT CDS complement(174302..174598) FT /transl_table=11 FT /gene="esxJ" FT /locus_tag="Mb1067c" FT /standard_name="ES6_2,TB11.0,QILSS" FT /product="PUTATIVE ESAT-6 LIKE PROTEIN 2" FT /note="Mb1067c, esxJ, len: 98 aa. Equivalent to Rv1038c, FT len: 98 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 98 aa overlap). esxJ, putative ESAT-6 FT like protein 2, similar to Q49945|U1756C, Mycobacterium FT leprae (100 aa), FASTA scores: opt: 375, E(): 7.7e-21, FT (58.3% identity in 96 aa overlap), almost identical to FT Rv1197, Rv1792, Rv2347c and Rv3620c. BELONGS TO THE ESAT6 FT FAMILY." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:P59803" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93927.1" FT /translation="MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGW FT SGMAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS" FT CDS complement(174744..175919) FT /transl_table=11 FT /gene="PPE15" FT /locus_tag="Mb1068c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb1068c, PPE15, len: 391 aa. Equivalent to Rv1039c, FT len: 391 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 391 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family of glycine-rich FT proteins, most similar to Rv2768c|AL008967|MTV002_33 FT Mycobacterium tuberculosis H37Rv (394 aa), FASTA scores: FT opt: 1721, E(): 0, (70.4% identity in 398 aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7U0T5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93928.1" FT /translation="MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAELGTTAASY FT ESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAGSQAMASAAAYEAAYAMT FT VPPEVVAANRALLAALVATNVLGINTPAIMATEALYAEMWAQDALAMYGYAAASGAAGM FT LQPLSPPSQTTNPGGLAAQSAAVGSAAATAAVNQVSVADLISSLPNAVSGLASPVTSVL FT DSTGLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAIPTAIFLANALNSGAPVAIA FT EGAIEAAEGAASAAAAGLADSVTPAGLGASLGEATLVGRLSVPAAWSTAAPATTAGATA FT LEGSGWTVAAEEAGPVTGMMPGMASAAKGTGAYAGPRYGFKPTVMPKQVVV" FT CDS complement(175996..176823) FT /transl_table=11 FT /gene="PE8" FT /locus_tag="Mb1069c" FT /product="PE FAMILY PROTEIN" FT /note="Mb1069c, PE8, len: 275 aa. Equivalent to Rv1040c, FT len: 275 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 275 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, most similar to FT AL008967|MTV002_34 Mycobacterium tuberculosis H37Rv (275 FT aa), FASTA scores: opt: 1111, E(): 0, (68.6% identity in FT 283 aa overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0T4" FT /protein_id="CAD93929.1" FT /translation="MSFLKTVPEELTAAAAQLGTIGAAMAAQNAAAAAPTTAIAPAALD FT EVSALQAALFTAYGTFYQQVSAEAQAMHDMFVNTLGISAGTYGVTESLNSSAAASPLSG FT ITGEASAIIQATTGLFPPELSGGIGNILNIGAGNWASATSTLIGLAGGGLLPAEEAAEA FT ASALGGEAALGELGALGAAEAALGEAGIAAGLGSASAIGMLSVPPAWAGQATLVSTTST FT LPGAGWTAAAPQAAAGTFIPGMPGVASAARNSAGFGAPRYGVKPIVMPKPATV" FT CDS complement(178019..178570) FT /pseudo FT /transl_table=11 FT /gene="Mb1070c" FT /locus_tag="Mb1070c" FT /product="PUTATIVE IS LIKE-2 TRANSPOSASE" FT /note="Mb1070c, -, len: 183 aa. Equivalent to Rv1041c, len: FT 287 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 183 aa overlap). Probable IS like-2 FT transposase, overlaps MTCY10G2.07. Similar to Q00430|X53945 FT insertion element IS869 hypothetical protein from FT Agrobacterium tumefaciens (186 aa), FASTA scores: opt: 173, FT E(): 0.00016, (40.9% identity in 176 aa overlap). Similar FT to Rv1150, C-terminal part of transposase of putative FT Mycobacterium tuberculosis IS like-1. MTCY10G2.07 and FT MTCY10G2.08 are frameshifted with respect to Mycobacterium FT tuberculosis Q50761 transposase, the 10G2 cosmid sequence FT appears to be correct." FT repeat_region complement(178019..178997) FT /mobile_element="insertion sequence:IS-LIKE" FT /locus_tag="IS-LIKE-1" FT /note="IS-LIKE-1, len: 979 nt. Equivalent to IS-LIKE, len: FT 978 nt, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 979 nt overlap). Insertion sequence, FT ISlike2, region identical to cos mid y348, blast score: FT 4902 (+1) 9377 10354 EM_NEW:MTAD20 A d000020 M. FT tuberculosis sequence from clone y348." FT CDS complement(178539..178946) FT /transl_table=11 FT /gene="Mb1071c" FT /locus_tag="Mb1071c" FT /product="PUTATIVE IS LIKE-2 TRANSPOSASE" FT /note="Mb1071c, -, len: 135 aa. Equivalent to Rv1042c, len: FT 135 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 135 aa overlap). Probable IS like-2 FT transposase, similar to Q50761 TRANSPOSASE from FT Mycobacterium tuberculosis (308 aa), FASTA scores: opt: FT 823, E(): 0, (99.1% identity in 117 aa overlap). Second FT copy is Rv1149." FT /db_xref="UniProtKB/TrEMBL:Q7U0T3" FT /protein_id="CAD93931.1" FT /translation="MTRVGVISDEFWAVVEPLMPSHEGKPGRRFSDHRLILEGIAWRFR FT TGSPWRDLPAEFGPWQTVWKRHHRWSLDGTCDEVFAHVAAVFGVDAEVAEDIEKLLSVD FT STNVRAHQHSAGACSDTLATGGTVELQEIRR" FT CDS complement(179229..180254) FT /transl_table=11 FT /gene="Mb1072c" FT /locus_tag="Mb1072c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1072c, -, len: 341 aa. Equivalent to Rv1043c, len: FT 341 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 341 aa overlap). Conserved hypothetical FT protein similar to AL096872|SC5F7.08 PUTATIVE FT LIPOATE-PROTEIN LIGASE from Streptomyces coelicolor (362 FT aa), FASTA scores: opt: 206, E(): 1.4e-05, (30.3% identity FT in 201 aa overlap). Weak similarity to P39668|YYXA_BACSU FT HYPOTHETICAL PROTEASE from Bacillus subtitis (400 aa), FT FASTA scores: opt: 159, E(): 0.013, (27.1% identity in 210 FT aa overlap)." FT /db_xref="GOA:Q7U0T2" FT /db_xref="UniProtKB/TrEMBL:Q7U0T2" FT /protein_id="CAD93932.1" FT /translation="MCAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSVA FT DFSRYLSTLGLPAAGDAVTLHRILSSMERAGLLLPLGWDPRLPVMGQKYISQGTISKGQ FT RGGNLWLSEVFGAELIIPSYNAVTVQLAGHDDAGNPVDSWGTGLVVDHNHVITNKHVVT FT GLAGTSAGLSVYPSSNHAEAELVNFSGTAHPHPTLDVAVIKFEMPEGKYIPRLGGMAFR FT DPDWADEVYVFGYPRVPMTAEMAITVQRGEVVNPAATTIPCRQKIFLYSAIARPGNSGG FT PIVAQDGRVIGLVVEDSAEAPSTGTGPNAAPFYRGIPSSEVIRALDELDFGGIVEMDTL FT P" FT CDS 180501..181124 FT /transl_table=11 FT /gene="Mb1073" FT /locus_tag="Mb1073" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1073, -, len: 207 aa. Equivalent to Rv1044, len: FT 207 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 207 aa overlap). Conserved hypothetical FT protein, similar to Mycobacterium tuberculosis hypothetical FT protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): FT 8.9e-06, (30.7% identity in 150 aa overlap). Some FT similarity to U36837|LLU36837_1 Lactococcus lactis plasmid FT pNP40 (287 aa), FASTA scores: opt: 147, E (): 0.0087, FT (29.7% identity in 91 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0T1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93933.1" FT /translation="MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQ FT LRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAVSWTLGRGVISHESALALHALADVN FT PSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTGTDP FT YQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA" FT CDS 181121..182002 FT /transl_table=11 FT /gene="Mb1074" FT /locus_tag="Mb1074" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1074, -, len: 293 aa. Equivalent to Rv1045, len: FT 293 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 293 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR014942" FT /db_xref="UniProtKB/TrEMBL:Q7U0T0" FT /protein_id="CAD93934.1" FT /translation="MTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQF FT AATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKDFDTVARRDIELIHEQLADAGETGG FT EGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDTLTS FT DALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDA FT DLMPTRSACIAIFEARAQHPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQ FT RFVARIDRATKR" FT CDS complement(182084..182677) FT /transl_table=11 FT /gene="Mb1075c" FT /locus_tag="Mb1075c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1075c, -, len: 197 aa. Equivalent to Rv1046c, len: FT 174 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 174 aa overlap). Hypothetical unknown FT protein. Start changed since first submission (-65 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U0S9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93935.1" FT /translation="MKVQARVGWNRRQLSAVGGRGQQLFANAPGHIPSTSHRRGTGDIN FT RKIDESLAGAARPQANANYGATSDPPLTHQPKPGSPTQVGPRSPSPPGLRGLVKQLPEV FT HQSSLHLDTVASLPSSRPSPHHTPLALRSRSGHFSPDEIRNRRSRKRSQSHMPPRTPPR FT GRCLRAPESARLGRRSAAHRHSIARNARAIPFVV" FT repeat_region 182747..184181 FT /mobile_element="insertion sequence:IS1081" FT /locus_tag="IS1081-1" FT /note="IS1081-1, len: 1435 nt. Equivalent to IS1081, len: FT 1450 nt, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 1435 nt overlap). Almost identical to FT Mycobacterium bovis IS1081 (7157 (-1) 60 14 94 FT EM_BA:MBBIS1081 X84741 Mycobacterium bovis BCG IS1081 DNA FT 4/96." FT repeat_region 182820..182834 FT /rpt_type=INVERTED FT /note="15 bp perfect inverted repeat, IRL, TCGCGTGATCCTTCG, FT flanking IS element IS1081." FT CDS 182872..184119 FT /transl_table=11 FT /gene="Mb1076" FT /locus_tag="Mb1076" FT /product="PUTATIVE IS1081 TRANSPOSASE" FT /note="Mb1076, -, len: 415 aa. Equivalent to Rv1047, len: FT 415 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 415 aa overlap). IS1081 transposase, most FT similar to TRA1_MYCBO|P35882 transposase for insertion FT sequence element (415 aa), FASTA scores: opt: 2675, E(): 0, FT (99.8% identity in 415 aa overlap). Contains PS01007 FT Transposases, Mutator family, signature" FT /db_xref="GOA:P60231" FT /db_xref="InterPro:IPR001207" FT /db_xref="UniProtKB/Swiss-Prot:P60231" FT /protein_id="CAD93936.1" FT /translation="MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALC FT GAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALT FT SVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTF FT LAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVAR FT GLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSI FT YDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIWSNNPQE FT RLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTST FT EEPAKQQTTNTPALTT" FT repeat_region complement(184129..184143) FT /rpt_type=INVERTED FT /note="15 bp perfect inverted repeat, IRR, TCGCGTGATCCTTCG, FT flanking IS element IS1081." FT CDS complement(184487..185602) FT /transl_table=11 FT /gene="Mb1077c" FT /locus_tag="Mb1077c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1077c, -, len: 371 aa. Equivalent to Rv1048c, len: FT 371 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 371 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7U0S8" FT /protein_id="CAD93937.1" FT /translation="MQASDRTWQSNFIRRWYFTETVEYRPLVKYDASMSWDERTVSALE FT GAFRSEVRARRVNGPHRDVIVSLDGAEFLVRWLTTGWPRQVAEALHATSRPDILAAPTM FT SPGARKAAHDAGVGWVDESGAADIHYRNTSTGTTLVIETKGAPPAPLDARIGWRRATLA FT VCEALLANIAGPTVASVVEATGLSMGSSAQALKFLEKNGHLASATARGPKSARLIVDRD FT ALLDAYAEAADKLRSPISISTGVLWRDPTAGVVKAGQLWDAAGIEWAATSALSASLLAP FT MQTEIAPMEIYVPGRSWSDLRRAAMAAGLQEIAGGRLILRFFPTPACARLTEQNLQGFR FT SMLWPRVYADLRTAGVRGEDAAEHLREAMTK" FT CDS 185835..186281 FT /transl_table=11 FT /gene="Mb1078" FT /locus_tag="Mb1078" FT /product="PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN" FT /note="Mb1078, -, len: 148 aa. Equivalent to Rv1049, len: FT 148 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 148 aa overlap). Probable transcriptional FT repressor protein, similar to many e.g. P74870 NEGATIVE FT REGULATOR OF EMR LOCUS EMR from Salmonella typhimurium (149 FT aa), FASTA scores: opt: 146, E(): 0.0011, (31.6% identity FT in 95 aa overlap). Contains probable helix-turn -helix FT motif at aa 58-79 (Score 1495, +4.28 SD)." FT /db_xref="GOA:Q7U0S7" FT /db_xref="HSSP:1B1B" FT /db_xref="InterPro:IPR000835" FT /db_xref="UniProtKB/TrEMBL:Q7U0S7" FT /protein_id="CAD93938.1" FT /translation="MGKGAAFDECACYTTRRAARQLGQAYDRALRPSGLTNTQFSTLAV FT ISLSEGSAGIDLTMSELAARIGVERTTLTRNLEVMRRDGLVRVMAGADARCKRIELTAK FT GRAALQKAVPLWRGVQAEVTASVGDWPRVRRDIANLGQAAEACR" FT CDS 186329..187234 FT /transl_table=11 FT /gene="Mb1079" FT /locus_tag="Mb1079" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb1079, -, len: 301 aa. Equivalent to Rv1050, len: FT 301 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 301 aa overlap). Probable oxidoreductase (EC FT 1.-.-.-) similar to many e.g. Rv1543|MTCY48.22C|Q10783 FT PUTATIVE OXIDOREDUCTASE CY48.22C (341 aa), FASTA scores: FT opt: 462, E(): 3e-22, (33.6% identity in 265 aa overlap)." FT /db_xref="GOA:Q7U0S6" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U0S6" FT /protein_id="CAD93939.1" FT /translation="MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGAL FT RRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGPVDAE FT TFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRKAFARFAGYSSAMH FT AIAGFSDALRQELRGSGIAVSVIHPALTQTPLLANVDPADMPPPFRSLTPIPVHWVAAA FT VLDGVARRRARVVVPFQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQ FT PTESAKAQAAQPERGYSSAR" FT CDS complement(187393..188148) FT /transl_table=11 FT /gene="Mb1080c" FT /locus_tag="Mb1080c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1080c, -, len: 251 aa. Equivalent to Rv1051c, len: FT 251 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 251 aa overlap). Conserved hypothetical FT protein, similar to LLU36837|U36837.1 protein encoded by FT Lactococcus lactis plasmid pNP40 (298 aa), FASTA scores: FT opt: 194, E(): 3.5e-06, (30.3% identity in 155 aa overlap). FT Contains possible helix-turn-helix motif at aa 197-218 FT (Score 1097, +2.92 SD)." FT /db_xref="GOA:Q7U0S5" FT /db_xref="InterPro:IPR014942" FT /db_xref="UniProtKB/TrEMBL:Q7U0S5" FT /protein_id="CAD93940.1" FT /translation="MRADVTAEHLTQVVRDIAVIDIDDGVAFNLDTSSVQEIRERADYP FT GLRVRVAMSVGPWQGIAAWDVSTGEPIAPWPTRVTIDRILGEPITLLGYAPETIIAEKG FT VTILERGITSTRWRDYVDIVQLDRRGIDDDELLRSARAVAQYRGATLEPVAPHLAGYGA FT VAQAKWATEHGRCQHCWRHWKPAHVGRRNMDLLDAKQVSEMIGVPVGTLRHWRHSDIGP FT ASFTLGRRVVYRRDEVSRWISKRESATRR" FT CDS 189171..189560 FT /transl_table=11 FT /gene="Mb1081" FT /locus_tag="Mb1081" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1081, -, len: 129 aa. Equivalent to Rv1052, len: FT 129 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 129 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7U0S4" FT /protein_id="CAD93941.1" FT /translation="MDCCEERGVARHKGLSQVGTPGCPRWSQAVSCRCSAYREAAVTAV FT QMPLTPGYGETPLPHDELAALLPEVVEVLDKPITRADVYDLEQGLQDQVFDLLMPTAVE FT GSLSLDELLSDHFVRDLHARMFGPV" FT CDS complement(189459..189734) FT /transl_table=11 FT /gene="Mb1082c" FT /locus_tag="Mb1082c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1082c, -, len: 91 aa. Equivalent to Rv1053c, len: FT 91 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 91 aa overlap). Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7U0S3" FT /protein_id="CAD93942.1" FT /translation="MDSHKVCMNNNTQLPTGPIIGVHPAVRDGVERVAYLDGDLLRCNT FT DVEFTSSPPPGPVLYRTKHTRVEIADEMVTEKLIKRQRAFNSRRHQ" FT CDS 190376..190690 FT /transl_table=11 FT /gene="Mb1083" FT /locus_tag="Mb1083" FT /product="PUTATIVE INTEGRASE (FRAGMENT)" FT /note="Mb1083, -, len: 104 aa. Equivalent to Rv1054, len: FT 104 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 104 aa overlap). Probable integrase FT (fragment), similar to Rv2309c|MTCY3G12_25|Z79702 FT hypothetical protein (shows similarity to integrases) from FT Mycobacterium tuberculosis (151 aa), FASTA scores: opt: FT 273, E(): 8.8e-13, (64.7% identity in 68 aa overlap); and FT to L39071|MSGINT_1 integrase from Mycobacterium FT paratuberculosis (191 aa), FASTA scores: opt: 105, E(): FT 0.9, (31.8% identity in 85 aaoverlap). This ORF continues FT in another frame as Rv1055|MTV017.08 but no error can be FT found to account for frameshift. Length extended since FT first submission (+36 aa)." FT /db_xref="InterPro:IPR014417" FT /db_xref="UniProtKB/TrEMBL:Q7U0S2" FT /protein_id="CAD93943.1" FT /translation="MTGKGIVESTTKTKRDRHVPVPEPVWRRLHAELPTDPNALVFPGR FT KGGFLPLGEYRWAFDNAGDQVGIEGWYRTVWGTPRPRWRSAQALTSRSCNGSLDTQQRR FT " FT CDS 190687..190821 FT /transl_table=11 FT /gene="Mb1084" FT /locus_tag="Mb1084" FT /product="POSSIBLE INTEGRASE (FRAGMENT)" FT /note="Mb1084, -, len: 44 aa. Equivalent to Rv1055, len: 44 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 44 aa overlap). Possible integrase (fragment); FT first 49 aa similar to Rv2309c|MTCY3G12_25|Z79702 FT hypothetical protein (shows similarity to integrases) from FT Mycobacterium tuberculosis (151 aa), FASTA scores: opt: FT 291, E(): 2.2e-16, (74.3% identity in 70 aa overlap); and FT to L39071|MSGINT_1 integrase from Mycobacterium FT paratuberculosis (191 aa), FASTA scores: opt: 146, E(): FT 8.3e-05, (52.1% identity in 48 aa overlap); and to many FT other integrases or transposases. Shortened since first FT submission (-34 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U0S1" FT /protein_id="CAD93944.1" FT /translation="MTLDRHGHLLNDDLAVWPMRCAKSSRTLRYHCGMRRRNRVGLRA" FT tRNA 190844..190917 FT /gene="leuX" FT /locus_tag="leuX" FT /note="leuX, len: 74 nt. Equivalent to leuX, len: 74 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 74 nt overlap). tRNA-Leu, anticodon taa." FT CDS 191076..191840 FT /transl_table=11 FT /gene="Mb1085" FT /locus_tag="Mb1085" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1085, -, len: 254 aa. Equivalent to Rv1056, len: FT 254 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 254 aa overlap). Conserved hypothetical FT protein, some similarity in C-terminal region of FT Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126 aa), FT FASTA scores: opt: 254, E(): 1.2e-10, (43.4% identity in FT 106 aa overlap); and to Rv1670. C-terminal region is FT similar to AL035569|SC8D9.02 hypothetical protein from FT Streptomyces coelicolor (113 aa), FASTA scores: opt: 282, FT E(): 4.5e-12, (48.0% identity in 100 aa overlap)." FT /db_xref="InterPro:IPR007361" FT /db_xref="UniProtKB/TrEMBL:Q7U0S0" FT /protein_id="CAD93945.1" FT /translation="MSVDYPQMAATRGRIEPAPRRVRGYLGHVLVFDTSAARYVWEVPY FT YPQYYIPLADVRMEFLRDENHPQRVQLGPSRLHSLVSAGQTHRSAARVFDVDGDSPVAG FT TVRFNWDPLRWFEEDEPIYGHPRNPYQRADALRSHRHVRVELDGIVLADTRSPVLLFET FT GIPTRYYIDPADIAFEHLEPTSTQTLCPYKGTTSGYWSVRVGDAVHRDLAWTYHYPLPA FT VAPIAGLVAFYNEKVDLTVDGVALPRPHTQFS" FT CDS 192844..194025 FT /transl_table=11 FT /gene="Mb1086" FT /locus_tag="Mb1086" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1086, -, len: 393 aa. Equivalent to Rv1057, len: FT 393 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 393 aa overlap). Conserved hypothetical FT protein, some similarity to X84710|MMSAG_1 surface antigen FT of Methanosarcina mazeii (491 aa), FASTA scores: opt: 363, FT E():6.2e-15, (31.3% identity in 294 aa overlap)." FT /db_xref="InterPro:IPR015943" FT /db_xref="UniProtKB/TrEMBL:Q7U0R9" FT /protein_id="CAD93946.1" FT /translation="MSVMNGREVARESRDAQVFEFGTAPGSAVVKIPVQGGPIGGIAIS FT RDGSLLVVTNNGTDTVSVVGTDTCRVTQTVTSVNEPFAIAMGNAEANRAYVSTVSSAYD FT AIAVIDVATNTVLGTHPLALSVSDLTLSPDDKYLYVSRNGTRGADVAVLDTTTGALIDV FT VDVSQAPGTTTQCVRMSPDGSVLYVGANGPSGGLLVVITTRAQSDGGRIGSRSRSRQKS FT SKPRGNQAAAGLRVVATIDIGSSVRDVALSPDGAIAYVASCGSDFGAVVDVIDTRTHQI FT TSSRAISEIGGLVTRVSVSGDADRAYLVSEDRVTVLCTRTHDVIGTIRTGQPSCVVESP FT DGKYLYIADYSGTITRTAVASTIVSGTEQLALQRRGSMQWFSPELQQYAPALA" FT CDS 194132..195763 FT /transl_table=11 FT /gene="fadD14" FT /locus_tag="Mb1087" FT /product="PROBABLE MEDIUM CHAIN FATTY-ACID-COA LIGASE FT FADD14 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA FT SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb1087, fadD14, len: 543 aa. Equivalent to Rv1058, FT len: 543 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 543 aa overlap). Probable fadD14, FT medium-chain fatty-acid-CoA synthetase (EC 6.2.1.-), highly FT similar to many e.g. CAC32346.1|AL583945 putative fatty FT acid CoA ligase from Streptomyces coelicolor (558 aa); FT N-terminus of NP_419738.1|NC_002696 FT medium-chain-fatty-acid--CoA ligase from Caulobacter FT crescentus (1006 aa); Q00594|ALKK_PSEOL FT MEDIUM-CHAIN-FATTY-ACID--COA LIGASE (EC 6.2.1.-) from FT Pseudomonas oleovorans (546 aa), FASTA scores: opt: 1468, FT E(): 0, (41.1% identity in 538 aa overlap); etc. Contains FT PS00455 Putative AMP-binding domain signature. BELONGS TO FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:Q7U0R8" FT /db_xref="HSSP:1BA3" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U0R8" FT /protein_id="CAD93947.1" FT /translation="MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEGYRHSSYRDVG FT QRAGQLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAY FT VTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAVGEGDTTPLREAGKTVLRFAELID FT AESPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGIGVGSSDK FT VLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVPTIWND FT VMHYLEKDPDHDMSSLRLVACGGSAVPESLMRTFEDKHDVQIRQLWGMTETSPLATMAW FT PPPGTPDDQHWAFRITQGQPVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYG FT GRDESKFDSGWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL FT EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERWAFVDEIPRT FT SVGKYDKKAIRSRYAEGAYQITEVHT" FT CDS 195839..196903 FT /transl_table=11 FT /gene="Mb1088" FT /locus_tag="Mb1088" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1088, -, len: 354 aa. Equivalent to Rv1059, len: FT 354 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 354 aa overlap). Conserved hypothetical FT protein, similar to Rv0926c|MTCY21C12.20c hypothetical FT protein from Mycobacterium tuberculosis (358 aa), FASTA FT scores: opt: 338, E(): 1.4e-14, (33.1% identity in 363 aa FT overlap)." FT /db_xref="GOA:Q7U0R7" FT /db_xref="InterPro:IPR000846" FT /db_xref="UniProtKB/TrEMBL:Q7U0R7" FT /protein_id="CAD93948.1" FT /translation="MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKD FT VGEIIGSPPLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVVTPLGWFY FT PSEKEAAPLEVAAQAGNATLHGAGIGPGAVTELFPLLLSVMSTGVTFVRSEEFSDLRSY FT GAPDVLRYVMGFGGTPDSALTGPMQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAV FT ATAPIDSPIGVIEPGQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGER FT YEIEVRGSPDTCVTIKGWQPQTVAAGLKSNPGIVATAAHCVNAIPATCAAPAGIQSFFD FT LPLITGRAAPGLAR" FT CDS 196956..197429 FT /transl_table=11 FT /gene="Mb1089" FT /locus_tag="Mb1089" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb1089, -, len: 157 aa. Equivalent to Rv1060, len: FT 157 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 157 aa overlap). Hypothetical unknown protein." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/TrEMBL:Q7U0R6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93949.1" FT /translation="MAKSVVVEQSRAIPVQSEDAFGGTLAAALPVICSHWYGLIPPIKE FT VRDQTGAWDSVGQARVITMVGGGRVREELTSVDPPRSFGYTLTDIKGPLAPLVALVEGK FT WSFAPADTGTTVTWQWTIHPRSALAAPVLPVFARMWRGYARGVLEKLSALLVG" FT CDS 197463..198326 FT /transl_table=11 FT /gene="Mb1090" FT /locus_tag="Mb1090" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1090, -, len: 287 aa. Equivalent to Rv1061, len: FT 287 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 287 aa overlap). Conserved hypothetical FT protein, similar to hypothetical proteins from various FT bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp. PCC6803 FT (304 aa), FASTA scores: opt: 245, E(): 1.2e-09, (27.1% FT identity in 258 aa overlap)." FT /db_xref="GOA:Q7U0R5" FT /db_xref="InterPro:IPR000583" FT /db_xref="UniProtKB/TrEMBL:Q7U0R5" FT /protein_id="CAD93950.1" FT /translation="MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRRNPDGTGLGVFDE FT HHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGSLDIRNTHPFLQDGRIFA FT HNGVVEGLDVLDERLREVGADDLVLGQTDSERVFALITASIRARDGNESAGLIDALRWL FT AANVPIYAVNVLLSTATDVWALRYPESHELYILDRRGDGAPEFHLRSKRIRAHSTHLRE FT RSSVVFATEPMDDNPRWRLLDAGELVHVDAALRVNRSLVLPDPPRHPIRREDLSEPVLH FT AQHTSA" FT CDS 198331..199188 FT /transl_table=11 FT /gene="Mb1091" FT /locus_tag="Mb1091" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1091, -, len: 285 aa. Equivalent to Rv1062, len: FT 285 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 285 aa overlap). Conserved hypothetical FT protein, some similarity to AL079356|SC6G9_10 hypothetical FT protein in Streptomyces coelicolor (289 aa), FASTA scores: FT opt: 556, E(): 1.2e-27, (39.0% identity in 287 aa overlap), FT and Z99111|BSUB0008_176 Bacillus subtilis (260 aa), FASTA FT scores: opt: 163, E(): 0.0013, (27.4% identity in 179aa FT overlap)" FT /db_xref="GOA:Q7U0R4" FT /db_xref="InterPro:IPR002641" FT /db_xref="UniProtKB/TrEMBL:Q7U0R4" FT /protein_id="CAD93951.1" FT /translation="MTTRRALVLAGGGLAGIAWETGVLRGIADESPAAARLLLDSDVLV FT GTSAGATVAAQISSGCPLDTLYERQLAETSAEIDPGVDIDAITDLFLTAVTEPHISTRR FT RLQRIGAVALAVDTVPESVRRQVIAQRLPSHDWPDRVLRVTAIDIATGELVVFHRESNV FT ALVDAVAASCSVPGAWPPVTIAGRRYMDGGVASSVNLGVADDCDAAVVLVPAGADAPSP FT FGGGAAAEIAAATGMVFAVFADDDSLAAFGPNPLDPLCRVNSAMAGRQQGRREAQAVAR FT LLGV" FT CDS complement(199189..200271) FT /transl_table=11 FT /gene="Mb1092c" FT /locus_tag="Mb1092c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1092c, -, len: 360 aa. Equivalent to Rv1063c, len: FT 360 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 360 aa overlap). Conserved hypothetical FT protein, similar to P37053|YCHK_ECOLI hypothetical protein FT from Escherichia coli (314 aa), FASTA scores: opt: 487, FT E(): 7.2e-23, (32.7% identity in 321 aa overlap). Also FT partially similar to Rv3239c|MTCY20B11.14c. BELONGS TO THE FT UPF0028 (SWS) FAMILY." FT /db_xref="GOA:P67099" FT /db_xref="InterPro:IPR002641" FT /db_xref="UniProtKB/Swiss-Prot:P67099" FT /protein_id="CAD93952.1" FT /translation="MPAPAALRVRGSSSPRVALALGSGGARGYAHIGVIQALRERGYDI FT VGIAGSSMGAVVGGVHAAGRLDEFAHWAKSLTQRTILRLLDPSISAAGILRAEKILDAV FT RDIVGPVAIEQLPIPYTAVATDLLAGKSVWFQRGPLDAAIRASIAIPGVIAPHEVDGRL FT LADGGILDPLPMAPIAGVNADLTIAVSLNGSEAGPARDAEPNVTAEWLNRMVRSTSALF FT DVSAARSLLDRPTARAVLSRFGAAAAESDSWSQAPEIEQRPAGPPADREEAADTPGLPK FT MGSFEVMNRTIDIAQSALARHTLAGYPADLLIEVPRSTCRSLEFHRAVEVIAVGRALAT FT QALEAFEIDDDESAAATIEG" FT CDS complement(200352..200771) FT /transl_table=11 FT /gene="lpqV" FT /locus_tag="Mb1093c" FT /product="PUTATIVE LIPOPROTEIN LPQV" FT /note="Mb1093c, lpqV, len: 139 aa. Equivalent to Rv1064c, FT len: 139 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 139 aa overlap). Putative lipoprotein FT LpqV. Has N-terminal signal sequence and appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:P65311" FT /db_xref="UniProtKB/Swiss-Prot:P65311" FT /protein_id="CAD93953.1" FT /translation="MRPSRYAPLLCAMVLALAWLSAVAGCSRGGSSKAGRSSSVAGTLP FT AGVVGVSPAGVTTRVDAPAESTEEEYYQACHAARLWMDAQPGSGESLIEPYLAVVQASP FT SGVAGSWHIRWAALTPARQAAVIVAARAAANAECG" FT CDS 200883..201449 FT /transl_table=11 FT /gene="Mb1094" FT /locus_tag="Mb1094" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1094, -, len: 188 aa. Equivalent to Rv1065, len: FT 188 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 188 aa overlap). Conserved hypothetical FT protein, some similarity to AL0209|SC4H8_11 hypothetical FT protein from Streptomyces coelicolor (182 aa), FASTA FT scores: opt: 156, E(): 0.0011, (31.3% identity in 195 aa FT overlap)." FT /db_xref="GOA:Q7U0R3" FT /db_xref="InterPro:IPR010300" FT /db_xref="UniProtKB/TrEMBL:Q7U0R3" FT /protein_id="CAD93954.1" FT /translation="MVMPLVTPTTAVPSPGPTRLRVADLLRATDQAADDVLGGRCDHLL FT PDGGVPQTQRWYTRIHGDEELDIWLISWVPGQPTELHDHGGSLGALTVLSGSLNEYRWD FT GRRLRRRRLDAGDQAGFPLGWVHDVVWAPRPIGGPDAAGMAVAPTLSVHAYSPPLTAMS FT YYEITERNTLRRQRTELTDQPEGSG" FT CDS 201446..201841 FT /transl_table=11 FT /gene="Mb1095" FT /locus_tag="Mb1095" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1095, -, len: 131 aa. Equivalent to Rv1066, len: FT 131 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 131 aa overlap). Conserved hypothetical FT protein, strong similarity to AL0209|SC4H8.10 hypothetical FT protein from Streptomyces coelicolor (132 aa), FASTA FT scores: opt: 429, E(): 5.2e-23, (57.1% identity in 119 aa FT overlap)." FT /db_xref="InterPro:IPR001763" FT /db_xref="UniProtKB/TrEMBL:Q7U0R2" FT /protein_id="CAD93955.1" FT /translation="MSRIDRVLEAARRRYRRLAADQVPEAARRGAVLVDIRPQAQRARE FT GEVPGALVIERNVLEWRCDPTSDARLPQAVDDDVEWVILCSEGYTSSLAAASLLDLGLH FT RATDVVGGYRALAAGGVLAELGGAVGG" FT CDS complement(201869..203884) FT /transl_table=11 FT /gene="PE_PGRS19" FT /locus_tag="Mb1096c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1096c, PE_PGRS19, len: 671 aa. Equivalent to FT Rv1067c, len: 667 aa, from Mycobacterium tuberculosis FT strain H37Rv, (98.5% identity in 673 aa overlap). Member of FT the Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins. Similar to Rv3388|MTV004.46 from FT Mycobacterium tuberculosis (731 aa), FASTA scores: opt: FT 2227, E(): 0, (55.6% identity in 710 aa overlap). Contains FT PS00583 pfkB family of carbohydrate kinases signature 1, FT probably fortuitous. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, 2 deletions each of 3 bp (ccg-* and FT cgc-*) and a 18 bp insertion leads to a longer product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (671 aa versus 667 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0R1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93956.1" FT /translation="MSFVLVSPSQLMAAAADVAGIGSAISAANAAALAPTSVLAAAGAD FT EVSAAVAALFSAHAGQYQQLGARAALFHEQFVQALTGAASAYASAEATNVEQQVLGLIN FT APTQALWGRPLIGNGADGTAANPNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIGN FT GGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPAGAIGAPGVAGGAGGAGGTAGLF FT GNGGVGGVGGDGGQGGNGAGAGASGTKGGDAGAGGAGGAGGWIHGHGGAGGDGGAGGAG FT GQASPGAPGPPSQPGGAGGAGGAGGRGGDGGSAGWLSGNGGDAGNGGGGGTAGGAGNGG FT QFGGDGGTGGTGGTAGAGGNGGRGAVLFGHGGNAGHGGAGGNGAAAGAGGEHVMATAGK FT GGTGGVGGDGGGGAGGGGGLLYGNGGAGGNGGAGGAGNSGGDGGTGLNAALGGNGGGGG FT VGGNAGAGGTGGSAGWLSGNGGAGGSGGSAGAGGAGGKGGDTPNGLAINPGIGGNGGDT FT GNAGNGGNGGSAARLFGGGGAGGAGGTGSTAGSGGSGGTNPPTGLQAAGGNGGSGHAGG FT HGGNGGGAGLLGGGTGGNGGGGGQGGLGAAAGGVDGNGGNGGNGGKGGDAQLVGDGGNG FT GNGGKGGAGLIAGLDGAGGAGGTRGLIFGNAGTPGQ" FT CDS complement(204217..206508) FT /transl_table=11 FT /gene="PE_PGRS20" FT /locus_tag="Mb1097c" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1097c, PE_PGRS20, len: 763 aa. Similar to Rv1068c, FT len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, FT (59.8% identity in 766 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins. Similar to AL021897|MTV017_19 M. FT tuberculosis H37Rv (667 aa), FASTA scores: opt: 1875, E(): FT 0, (55.0% identity in 667 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) FT deletion, leads to a longer product compared to the homolog FT in Mycobacterium tuberculosis strain H37Rv (763 aa versus FT 463 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0R0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93957.1" FT /translation="MSYMIAVPDMLSSAAGDLASIGSSINASTRAAAAATTRLLPAAAD FT EVSAHIAALFSGHGEGYQAIARQMAAFHDQFTLALTSSAGAYASAEATNVEQQVLGLIN FT APTQALWGRPLIGNGADGTAANPNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIGN FT GGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPAGAIGAPGVAGGAGGAGGSAGLF FT GNGGAGGAGGAGGQGGAGIGGADGTKGGDAGAGGAGGAGGWIHGHGGVGGDGGTGGQGG FT DGVQGEPGDTGAAGGAGGAGGRGGDGGSAGWLSGNGGDAGTGGGGGNAGAGGEGGIFGG FT NGGNGGTGGTAGGGGNGGRGAALFGHGGNAGHGGAGGNGAAGGNGADTQLGISGKGGTG FT GGGGGAGAGGTGGDGGLLYGNGGAGGNGGNGGAAGKGGIGAPGLSTAQGGDGGNGGSGG FT NAGNGGNGGRGSVLFGHGGNAGHGGAGGNGAVSGNGGSSITAVGGKGGTGGGGGGGAGG FT TGGDAGLLYGNGGAGGTGGSGGAGARGGDGGAGSGTAQGGDGGAGGVGGNAGNGGNGGS FT AGWLSGNGGTGGGGGTAGAGGQGGNGNSGIDPGNGGQGADTGNAGNGGHGGSAAKLFGD FT GGAGGAGGMGSTGGTGGGGGFGGGTGGNGGNGHAGGAGGSGGTAGLLGSGGTGGDGGNG FT GLGAGSGAKGNGGNGGDGGKGGDAQLIGNGGNGGNGGKGGTGLMPGINGTGGAGGSRGQ FT ISGNPGTPGQ" FT CDS complement(206870..208633) FT /transl_table=11 FT /gene="Mb1098c" FT /locus_tag="Mb1098c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1098c, -, len: 587 aa. Equivalent to Rv1069c, len: FT 587 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 587 aa overlap). Conserved hypothetical FT protein, hydrophobic regions in N-terminal domain. Similar FT in part to O07136|B1306.04C B1306.04c protein from FT Mycobacterium leprae (89 aa), FASTA scores: opt: 229, E(): FT 1.3e-07, (54.2% identity in 72 aa overlap)." FT /db_xref="InterPro:IPR012037" FT /db_xref="UniProtKB/TrEMBL:Q7U0Q9" FT /protein_id="CAD93958.1" FT /translation="MTEPAAATTTNASDEPATGAEQAVDTAATPQTPEPQPIRSTWWIR FT HYTFTGTAMGLVFVWFSMTPSLLPRGPLFQGLVSGICGAFGYGLGVFAVWLVRYMRSHN FT SSPPPPRWAWPPLIAVGAVGMVGMAVQFHVWQDDVRDLMGVEHLRWYDYPLAAALSLVV FT LFTLVEIGQFIRWLFRFLVGQVDRIAPFRVSAAIVVVLLVVLTITLLNGVVLKFAMNSM FT NSTFAAVNNEMNPDSAPPKTPLRSGGPGSLVSWESLGHQGRIFVHSGPTIADLTAFNGT FT PAVEPIRTYAGLNSADGIMATAELAARELARTGGLRRAVVAVATSTGTGWINEAEASAL FT EYMYNGDTAIVSMQYSFLPSWLSFLVDKENARHAGEALFEAVDKLIRQLPESQRPKLVV FT FGESLGSFGGEAPFMNLNNILARTDGALFSGPTFNNTVWNSLTANRDAGSPQWLPIYDD FT GRNVRFVARARDLQRPDAPWGRPRVVYLQHASDPIAWWTPRLLFREPDWLREQRGYDVL FT PQTRWIPVVTFVQVSADMAVATHVPDGHGHRYVATVADGWAAVLSPPGWTQQKTERLQP FT LLHANAKPFGS" FT CDS complement(208630..209403) FT /transl_table=11 FT /gene="echA8" FT /locus_tag="Mb1099c" FT /product="PROBABLE ENOYL-CoA HYDRATASE ECHA8 (ENOYL FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" FT /EC_number="4.2.1.17" FT /note="Mb1099c, echA8, len: 257 aa. Equivalent to Rv1070c, FT len: 257 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 257 aa overlap). Probable echA8, FT enoyl-CoA hydratase (EC 4.2.1.17), equivalent to FT O07137|B1306.05c putative enoyl-CoA hydratase/isomerase FT from Mycobacterium leprae (257 aa), FASTA scores: opt: FT 1417, E(): 0, (86.4% identity in 257 aa overlap). Also FT highly similar to others e.g. NP_106219.1|NC_002678 enoyl FT CoA hydratase from Mesorhizobium loti (257 aa); FT L39265|RHMRPST_2 enoyl-CoA hydratase from Rhizobium FT melilotii (257 aa), FASTA scores: opt: 1100, E(): 0, (66.9% FT identity in 257 aa overlap); FT AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase FT from Pseudomonas putida (257 aa); etc. Contains PS00166 FT Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE FT ENOYL-CoA HYDRATASE/ISOMERASE FAMILY. TBparse score is FT 0.881." FT /db_xref="GOA:P64017" FT /db_xref="HSSP:1MJ3" FT /db_xref="InterPro:IPR018376" FT /db_xref="UniProtKB/Swiss-Prot:P64017" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93959.1" FT /translation="MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELDD FT DPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTADFFATWGKLAAVRTPTIAAVAGY FT ALGGGCELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGR FT TMDAAEAERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESSLSEG FT LLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR" FT CDS complement(209415..210452) FT /transl_table=11 FT /gene="echA9" FT /locus_tag="Mb1100c" FT /product="POSSIBLE ENOYL-COA HYDRATASE ECHA9 (ENOYL FT HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)" FT /EC_number="4.2.1.17" FT /note="Mb1100c, echA9, len: 345 aa. Equivalent to Rv1071c, FT len: 345 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 345 aa overlap). Possible echA9, FT enoyl-CoA hydratase (EC 4.2.1.17), equivalent to FT Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase FT from Mycobacterium leprae (345 aa), FASTA scores: opt: FT 1799, E(): 0, (77.7% identity in 345 aa overlap). Also FT similar to many eukaryotic and prokaryotic enoyl-CoA FT hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA FT hydratase protein from Sinorhizobium meliloti (356 aa); FT NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family FT protein from Caulobacter crescentus (350 aa); Q19278 FT PROTEIN SIMILAR TO ENOYL-COA HYDRATASES from Caenorhabditis FT elegans (386), FASTA scores: opt: 787, E(): 0, (38.5% FT identity in 348 aa overlap); etc." FT /db_xref="GOA:Q7U0Q8" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:Q7U0Q8" FT /protein_id="CAD93960.1" FT /translation="MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSW FT EHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKDGVEARRFWRHEYLLNALIGRFAKP FT YVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGALGL FT HAALTGAPFSGADAIALGFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAA FT QRDWIDECYAGDSVADIVAALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDT FT LEDVLIQDYRVSSASLRSHDLVEGIRAQLIDKDRNPNWSPATLDAITAADIEAYFEPVD FT DDLSF" FT CDS 210639..211475 FT /transl_table=11 FT /gene="Mb1101" FT /locus_tag="Mb1101" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb1101, -, len: 278 aa. Equivalent to Rv1072, len: FT 278 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 278 aa overlap). Probable conserved FT transmembrane protein, equivalent to O07139|B1306.07|Y13803 FT Protein B1306.07 from Mycobacterium leprae (220 aa), FASTA FT scores: opt:1032, E(): 0, (75.0% identity in 220 aa FT overlap); and at the C-terminal end to Q50056|U1740D FT Mycobacterium leprae (96 aa), FASTA scores: opt: 381, E(): FT 1.2e-18, (71.6% identity in 81 aa overlap). Similar to FT Q54192|M80628|STMBLDA_1 TRANSFER RNA-LEU (BLDA) GENE AND FT ORF from Streptomyces griseus (293 aa), FASTA scores: FT opt:558, E(): 4.7e-30, (41.5% identity in 299 aa overlap). FT TBparse score is 0.896." FT /db_xref="GOA:Q7U0Q7" FT /db_xref="InterPro:IPR010539" FT /db_xref="UniProtKB/TrEMBL:Q7U0Q7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93961.1" FT /translation="MRETSNPVFRSLPKQRGGYAQFGTGTAQQGFPADPYLAPYREAKA FT TRPLTIDDVVTKTGLTLAMLAGTAVVSYFLVASNVALAMPLTLVGALGGLALVLVATFG FT RKQDNPAIVLSYAALEGLFLGAISFVLANFTVASANAGVLIGEAILGTMGVFFGMLVVY FT KTGAIRVTPKFTRMVVAALFGVLVLMLGNLVLAMFNVGGGEGLGLRSPGPLGIIFSLVC FT IGIAAFSFLIDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYIEILRLLSYLQNE" FT CDS 211591..212442 FT /transl_table=11 FT /gene="Mb1102" FT /locus_tag="Mb1102" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1102, -, len: 283 aa. Equivalent to Rv1073, len: FT 283 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 283 aa overlap). Conserved hypothetical FT protein, similar to several hypothetical mycobacterial FT proteins e.g. Rv1482c|Z79701|MTCY277.03 Mycobacterium FT tuberculosis (339 aa), FASTA scores: opt: 810, E(): 0, FT (47.4% identity in 272 aa overlap); FT Rv3555c|Z92774|MTCY6G11_2 Mycobacterium tuberculosis (289 FT aa), FASTA scores: opt: 704, E(): 0, (44.4% identity in 259 FT aa overlap); and Rv3517, etc., and GIR10|AF002133_10 M. FT avium strain GIR10 (346 aa), FASTA scores: opt: 802, E(): FT 0, (48.1% identity in 270 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0Q6" FT /protein_id="CAD93962.1" FT /translation="MGAQPFIGSEALAAGLISWHELGKYYTAIMPNVYLDKRLKPSLRQ FT RVIAAWLWSGRKGVIAGASASALHGAKWVDDHALVELIWRNARAPNGVRTKDELLLDGE FT VQRLCGLTVTTVERTAFDLGRRPPLGQAITRLDALANATDFKINDVRELARKHPHTRGL FT RQLDKALDLVDPGAQSPKETWLRLLLINAGFPRPSTQIPLLGVYGHPKYFLDMGWEDIM FT LAVEYDGEQHRLSRDQFVKDVERLEYIRRAGWTHIRVLADHKGPDVVRRVRQAWDTLTS FT RR" FT CDS complement(212516..213733) FT /transl_table=11 FT /gene="fadA3" FT /locus_tag="Mb1103c" FT /product="PROBABLE BETA-KETOACYL CoA THIOLASE FADA3" FT /EC_number="2.3.1.-" FT /note="Mb1103c, fadA3, len: 405 aa. Equivalent to Rv1074c, FT len: 405 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 405 aa overlap). Probable fadA3, FT beta-ketoacyl CoA thiolase (EC 2.3.1.-), highly similar to FT many involved in beta-oxidation e.g. CAB89028.1|AL353870 FT beta-ketoadipyl-CoA thiolase from Streptomyces coelicolor FT (395 aa); P77525|PAAJ_ECOLI probable beta-ketoadipyl CoA FT thiolase from Escherichia coli (401 aa), FASTA scores: opt: FT 1034, E(): 5.4e-56, (43.5% identity in 416 aa overlap) and FT X97452 acetyl-CoA acetyltransferase (thiolase) from FT Escherichia coli (401 aa), FASTA scores: opt: 1043, E(): 0, FT (43.4% identity in 415 aa overlap); Q43935|CATF_ACICA FT beta-ketoadipyl CoA thiolase from Acinetobacter FT calcoaceticus (401 aa), FASTA scores: opt: 992, E(): 0, FT (41.5% identity in 415 aa overlap); etc. Contains PS00737 FT Thiolases signature 2, and PS00445 FGGY family of FT carbohydrate kinases signature 2, although this is probably FT fortuitous. BELONGS TO THE THIOLASE FAMILY." FT /db_xref="GOA:Q7U0Q5" FT /db_xref="HSSP:1AFW" FT /db_xref="InterPro:IPR002155" FT /db_xref="UniProtKB/TrEMBL:Q7U0Q5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93963.1" FT /translation="MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPAL FT NPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDFLPGTTVNRYCSSSLQTTRMAFHAI FT KAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPRTDQ FT KLPDIYIAMGQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDG FT TTVSTDDGPRPGTTYEKVSELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGL FT TPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAFAVQVLGSAR FT ELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAM FT VIERLA" FT CDS complement(213786..214730) FT /transl_table=11 FT /gene="Mb1104c" FT /locus_tag="Mb1104c" FT /product="CONSERVED EXPORTED PROTEIN" FT /note="Mb1104c, -, len: 314 aa. Equivalent to Rv1075c, len: FT 314 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 314 aa overlap). Possibly exported protein, as FT it contains a N-terminal signal sequence, hydrophobic FT domain from aa 7-25. Similar to U15183|MLU15183_2 FT Mycobacterium leprae cosmid B1740 (106 aa), FASTA scores: FT opt: 207, E(): 1.6e-06, (42.6% identity in 101 aa overlap). FT Also weak similarity to many glyceraldehyde-3-phosphate FT dehydrogenases e.g. Q41595|G3PC_TAXBA Taxus baccata (340 FT aa), FASTA scores: opt: 147, E(): 0.027, (27.5% identity in FT 189 aa overlap)." FT /db_xref="GOA:Q7U0Q4" FT /db_xref="InterPro:IPR001087" FT /db_xref="UniProtKB/TrEMBL:Q7U0Q4" FT /protein_id="CAD93964.1" FT /translation="MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSFD FT APPRADGVYTRGGGPVQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGLAE FT QTGKRIRLSTKAIVGATSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPSAQR FT LADCVRRLRTRGAVVVVGTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAAGGVP FT VPLGHLLAPKFRAMPELMFSADRYHPSAPAYALAADLLFLALRDALTEKLDIPIHETPS FT RPGTATLEPGHTRHSMMSRLRRPRPARAVPTGG" FT CDS 215127..216020 FT /transl_table=11 FT /gene="lipU" FT /locus_tag="Mb1105" FT /product="PUTATIVE LIPASE LIPU" FT /EC_number="3.1.-.-" FT /note="Mb1105, lipU, len: 297 aa. Equivalent to Rv1076, FT len: 297 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 297 aa overlap). Putative lipU, lipase FT (EC 3.1.-.-), very similar to several Mycobacterium FT tuberculosis proteins e.g. Z95390|Rv3487c|MTCY13E12.41c FT (277 aa), FASTA scores: opt: 1225, E(): 0, (76.0% identity FT in 246 aa overlap); Rv1426c, etc. Also similar to esterases FT and lipases of around 300 aa e.g. Q44087 ESTERASE PRECURSOR FT from Acinetobacter lwoffii esterase (303), FASTA scores: FT opt: 427, E(): 1.9e-21, (32.5% identity in 280 aa overlap). FT Equivalent to AL035159|MLCB1450 _7 Mycobacterium leprae FT (335 aa), FASTA scores: opt: 1588, E(): 0, (79.7% identity FT in 296 aa overlap)." FT /db_xref="GOA:Q7U0Q3" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:Q7U0Q3" FT /protein_id="CAD93965.1" FT /translation="MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPASTTVRAAVSLPN FT ASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSKFADSPVLVVDYRL FT IPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSAGGYLALALAQRLQEVGEEPAAL FT VAISPLLQLAKEHKQAHPNIKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLE FT HITPGLPRTLIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEA FT IRSLRQIGEYIREATG" FT CDS 216077..217471 FT /transl_table=11 FT /gene="cbs" FT /locus_tag="Mb1106" FT /standard_name="cysM2" FT /product="Probable cystathionine beta-synthase CBS (Serine FT sulfhydrase) (Beta-thionase) (Hemoprotein H-450)" FT /EC_number="4.2.1.22" FT /note="Mb1106, cbs, len: 464 aa. Equivalent to Rv1077, len: FT 464 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 464 aa overlap). Probable cbs (previously FT cysM2), cystathionine beta-synthase (EC 4.2.1.22), similar FT throughout its length to many eukaryotic cystathionine FT beta-synthases e.g. P32232|CBS_RAT CYSTATHIONINE FT BETA-SYNTHASE (560 aa), FASTA scores: opt: 951, E(): 0, FT (40.2% identity in 450 aa overlap); also similar in FT N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK FT Mycobacterium tuberculosis (310 aa), FASTA scores: opt: FT 855, E(): 0, (46.8% identity in 314 overlap); and other FT cysteine synthase proteins e.g. Rv1336, Rv0848, etc. FT Contains PS00217 Sugar transport proteins signature 2 FT probably spurious. BELONGS TO THE CYSTEINE FT SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY." FT /db_xref="GOA:Q7VEZ8" FT /db_xref="HSSP:1JBQ" FT /db_xref="InterPro:IPR001926" FT /db_xref="UniProtKB/TrEMBL:Q7VEZ8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93966.1" FT /translation="MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKD FT RIAVKMIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDKRN FT VLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPEGPASHYVTTGP FT EIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRIVGADPEGSVYSGGAGRPYL FT VEGVGEDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVA FT EEAGPDALIVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGA FT LPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGR FT AKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLS FT EGAGRR" FT CDS 217673..218395 FT /transl_table=11 FT /gene="pra" FT /locus_tag="Mb1107" FT /product="Probable Proline-rich antigen homolog pra" FT /note="Mb1107, pra, len: 240 aa. Equivalent to Rv1078, len: FT 240 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 240 aa overlap). Probable pra, FT Proline-rich antigen homolog, equivalent to X65546|MLPRAG_1 FT proline rich antigen from Mycobacterium leprae (249 aa), FT FASTA scores: opt: 1162, E(): 3.3e-30, (64.8% identity in FT 253 aa overlap). Has potential hydrophobic domains." FT /db_xref="InterPro:IPR010432" FT /db_xref="UniProtKB/TrEMBL:Q7U0Q2" FT /protein_id="CAD93967.1" FT /translation="MTEQPPPGGSYPPPPPPPGPSGGHEPPPAAPPGGSGYAPPPPPSS FT GSGYPPPPPPPGGGAYPPPPPSAGGYAPPPPGPAIRTMPTESYTPWITRVLAAFIDWAP FT YVVLVGIGWVIMLVTQTSSCVTSISEYDVGQFCVSQPSMIGQLVQWLLSVGGLAYLVWN FT YGYRQGTTGSSIGKSVLKFKVVSETTGQPIGFGMSVVRQLAHFIDAIICFVGFLFPLWD FT AKRQTLADKIMTTVCVPI" FT CDS 218427..219593 FT /transl_table=11 FT /gene="metB" FT /locus_tag="Mb1108" FT /product="PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) FT (O-SUCCINYLHOMOSERINE [THIOL]-LYASE)" FT /EC_number="2.5.1.48" FT /note="Mb1108, metB, len: 388 aa. Equivalent to Rv1079, FT len: 388 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 388 aa overlap). Probable metB, FT cystathionine gamma-synthase (EC 4.2.99.9) (see citation FT below). P46807|METB_MYCLE CYSTATHIONINE GAMMA-SYNTHASE from FT Mycobacterium leprae (EC 4.2.1.22) (388 aa), FASTA scores: FT opt: 2220, E(): 0, (87.3% identity in 387 aa overlap). Also FT similar to other Mycobacterium tuberculosis enzymes FT involved in methionine synthesis e.g. Rv0391 and Rv3340. FT Contains PS00868 Cys/Met metabolism enzymes FT pyridoxal-phosphate attachment site. BELONGS TO THE FT TRANS-SULFURATION ENZYMES FAMILY." FT /db_xref="GOA:P66876" FT /db_xref="HSSP:1GC0" FT /db_xref="InterPro:IPR015422" FT /db_xref="UniProtKB/Swiss-Prot:P66876" FT /protein_id="CAD93968.1" FT /translation="MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQD FT GVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHV FT VIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSI FT ADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALV FT TNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPS FT VSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGV FT ESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG" FT CDS complement(219664..220158) FT /transl_table=11 FT /gene="greA" FT /locus_tag="Mb1109c" FT /product="PROBABLE TRANSCRIPTION ELONGATION FACTOR GREA FT (Transcript cleavage factor greA)" FT /note="Mb1109c, greA, len: 164 aa. Equivalent to Rv1080c, FT len: 164 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 164 aa overlap). Probable greA, FT transcription elongation factor G, closest to FT P46808|GREA_MYCLE TRANSCRIPTION ELONGATION FACTOR G from FT Mycobacterium leprae (202 aa), FASTA scores: opt: 1005, FT E(): 0, (94.5% identity in 164 aa overlap); and similar to FT many e.g. P21346|GREA_ECOLI from Escherichia coli (158 aa), FT FASTA scores: opt: 257, E(): 5.7e-10, (37.2% identity in FT 148 aa overlap); etc. Contains two PS00829 and one PS00830 FT Prokaryotic transcription elongation factors signatures 1 FT and 2, respectively. BELONGS TO THE GREA/GREB FAMILY." FT /db_xref="GOA:P64280" FT /db_xref="HSSP:1GRJ" FT /db_xref="InterPro:IPR018151" FT /db_xref="UniProtKB/Swiss-Prot:P64280" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93969.1" FT /translation="MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDLR FT ENGGYHAAREEQGQQEARIRQLQDLLSNAKVGEAPKQSGVALPGSVVKVYYNGDKSDSE FT TFLIATRQEGVSDGKLEVYSPNSPLGGALIDAKVGETRSYTVPNGSTVSVTLVSAEPYH FT S" FT CDS complement(220344..220778) FT /transl_table=11 FT /gene="Mb1110c" FT /locus_tag="Mb1110c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb1110c, -, len: 144 aa. Equivalent to Rv1081c, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 144 aa overlap). Probable conserved membrane FT protein, with hydrophobic stretch from aa 26 - 48, highly FT similar to NP_302548.1|NC_002677 conserved membrane protein FT from Mycobacterium leprae." FT /db_xref="UniProtKB/TrEMBL:Q7U0Q1" FT /protein_id="CAD93970.1" FT /translation="MTHTPIPRPDARYGRPRLSRRARRRVAIALGVLVAAAGIVIAVIG FT YQRISTSAVTGSLVGYRLVDDETASVTISVTRSDPSRPVACIVRVRATNGSETGRRELL FT VPPSEATTVQVTTTVKSSQPPVMADVYGCGTEVPSYLRLP" FT CDS 220880..221746 FT /transl_table=11 FT /gene="mca" FT /locus_tag="Mb1111" FT /product="Mycothiol conjugate amidase Mca (Mycothiol FT S-conjugate amidase)" FT /note="Mb1111, mca, len: 288 aa. Equivalent to Rv1082, len: FT 288 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 288 aa overlap). mca, mycothiol conjugate FT amidase (see citation below), equivalent to FT NP_302547.1|NC_002677 conserved hypothetical protein from FT Mycobacterium leprae (290 aa), FASTA scores: opt: 1737, FT E(): 0, (86.4% identity in 287 aa overlap); and similar to FT Q54358|X79146 lmbE protein from Streptomyces lincolnensis FT (270 aa). Also similar to Rv1170|MTV005.06|MSHB GlcNAc-Ins FT deacetylase from Mycobacterium tuberculosis (303 aa), FASTA FT scores: opt: 411, E(): 9.4e-20, (35.8% identity in 299 aa FT overlap)." FT /db_xref="InterPro:IPR017811" FT /db_xref="UniProtKB/TrEMBL:Q7VEZ7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93971.1" FT /translation="MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGERG FT EILNPAMDLPDVHGRIAEIRRDEMTKAAEILGVEHTWLGFVDSGLPKGDLPPPLPDDCF FT ARVPLEVSTEALVRVVREFRPHVMTTYDENGGYPHPDHIRCHQVSVAAYEAAGDFCRFP FT DAGEPWTVSKLYYVHGFLRERMQMLQDEFARHGQRGPFEQWLAYWDPDHDFLTSRVTTR FT VECSKYFSQRDDALRAHATQIDPNAEFFAAPLAWQERLWPTEEFELARSRIPARPPETE FT LFAGIEP" FT CDS 221743..222009 FT /transl_table=11 FT /gene="Mb1112" FT /locus_tag="Mb1112" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1112, -, len: 88 aa. Equivalent to Rv1083, len: 88 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 88 aa overlap). Conserved hypothetical protein, FT similar to U15183|MLU15183_9 hypothetical protein from FT Mycobacterium leprae (167 aa), FASTA scores: opt: 332, E(): FT 1.2e-13, (58.4% identity in 101 aa overlap). Hydrophobic FT domain aa 25-43." FT /db_xref="UniProtKB/TrEMBL:Q7U0Q0" FT /protein_id="CAD93972.1" FT /translation="MNQILLSVIAEGGPGNTGPDFGKASPVGLLVIVLLVIATLFLVRS FT MNQQLKKVPKSFDRDHPELDQAADEGTDRDGPARPPGPPHESG" FT CDS 221996..224017 FT /transl_table=11 FT /gene="Mb1113" FT /locus_tag="Mb1113" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1113, -, len: 673 aa. Equivalent to Rv1084, len: FT 673 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 673 aa overlap). Conserved hypothetical FT protein, similar to P37512|YYAL_BACSU hypothetical protein FT from Bacillus subtilis (689 aa), FASTA scores: opt: 1063, FT E(): 0, (36.5% identity in 696 aa overlap); FT AE0009|AE000983_10 Archaeoglobus fulgidus section 1 (642 FT aa), FASTA scores: opt: 1018, E(): 0, (37.2% identity in FT 600 aa overlap). Also similar to AE001938|AE001938_9 FT Deinococcus radiodurans (690 aa), FASTA scores: opt: 1097, FT E(): 0, (41.6% identity in 694 aa overlap)." FT /db_xref="GOA:Q7U0P9" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/TrEMBL:Q7U0P9" FT /protein_id="CAD93973.1" FT /translation="MSPANPSGTNTLALATSPYLRQHADNPVHWQQWTPQALAEAAARA FT VPILLSVGYAACHWCHVMAHESFDDDEVAAAMNAGFVCIKVDREERPDIDAVYMNATVA FT LTGQGGWPMTCFLTPNGRPFFCGTYYPKAAFLQLLSAISETWRERRAEVEQASDHIAAE FT LRSMASGLPGGGPEVAPELCDDAVAGVLREQDTAHGGFGGAPKFPPSALLEALMRHYER FT TRSPAALEAVARTGNAMARGGIYDQLGGGFARYSVDGAWVVPHFEKMLYDNALLLRAYA FT HWARRTGDPLARRVAAQTARFLLDELGSKAPADMFTSSLDADADGREGSTYVWTPVQLT FT EVLGGDDGRWAAEVFGVTEAGTFEHGTSVLQLPADPDDAARLDRVRAALLVARLARAQP FT ARDDKVVTSWNGLAITALAEASVALDDPALAHAARRCATRLLDLHVVDGRLRRASLGGV FT VGDSAAILEDHAMLATGLLALYQLTSEGAWLTAATGLLDTAVAHFGDPQRPGRWFDTAD FT DAERLMLRPSDPLDGATPSGASSIAEALLTAGHVVDGARAERYWQLAADTLRAHAVLLA FT RAPRSAGHWLAVAEAVVRGPLQIAVACDLPRSSLLADARRLAPGGAIVVGGAAGSSALL FT VGRDRVAGADAAYVCRGRVCDLPVTSAAELATALGVPG" FT CDS complement(224116..224844) FT /transl_table=11 FT /gene="Mb1114c" FT /locus_tag="Mb1114c" FT /product="POSSIBLE HEMOLYSIN-LIKE PROTEIN" FT /note="Mb1114c, -, len: 242 aa. Equivalent to Rv1085c, len: FT 242 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 242 aa overlap). Possible hemolysin-like FT protein, integral membrane protein, similar to many FT hemolysins, and hypothetical proteins e.g. FT U28375|ECU28375_49 Hypothetical protein from Escherichia FT coli (219 aa), FASTA scores: opt: 308, E(): 7.5e-15, (30.6% FT identity in 180 aa overlap); AE0011|HIAE001124_2 FT Hypothetical protein from Borrelia burgdorferi (233 aa), FT FASTA scores: opt: 305, E(): 1.3e-14, (25.6% identity in FT 203 aa overlap). Also weakly similar to HLY3_BACCE|P54176 FT haemolysin from Bacillus cereus (219 aa), FASTA scores: FT opt: 247, E(): 8.7e-12, (27.5% identity in 171 aa overlap). FT Also similar to AE002027|AE002027_8 probable hemolysin from FT Deinococcus radiodurans (219 aa), FASTA scores: opt: 354, FT E(): 1.8e-16, (31.1% identity in 219 aa overlap)." FT /db_xref="GOA:P67158" FT /db_xref="InterPro:IPR005744" FT /db_xref="UniProtKB/Swiss-Prot:P67158" FT /protein_id="CAD93974.1" FT /translation="MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYSA FT GTAVLAGASLVAVSWAVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWMKR FT ADHSMIFVFIAGSYTPFALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVGVPL FT YLLLGWVAVWYTATILHNAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGYHEFF FT HACTAVAAICHYIAMWFVVF" FT CDS 224955..225743 FT /transl_table=11 FT /gene="Mb1115" FT /locus_tag="Mb1115" FT /product="SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE FT SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE) FT (Z-FPP SYNTHETASE) (Z-FARNESYL DIPHOSPHATE SYNTHETASE) FT (GERANYLTRANSTRANSFERASE) (FARNESYL PYROPHOSPHATE FT SYNTHETASE)" FT /EC_number="2.5.1.10" FT /note="Mb1115, -, len: 262 aa. Equivalent to Rv1086, len: FT 262 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 262 aa overlap). Short (C15) chain FT Z-isoprenyl diphosphate synthase (EC 2.5.1.10) (see FT citations below), equivalent to NP_302598.1|NC_002677 FT possible undecaprenyl pyrophosphate synthetase from FT Mycobacterium leprae (262 aa), similar to many hypothetical FT proteins and several potential members of the upp synthase FT family e.g. NP_296167.1|NC_001263 undecaprenyl diphosphate FT synthase from Deinococcus radiodurans (339 aa); FT P20182|YT14_STRFR Hypothetical protein from Streptomyces FT fradiae (259 aa), FASTA scores: opt: 840, E(): 0, (51.0% FT identity in 259 aa overlap); and P38118|YARF_CORGL FT Hypothetical protein from Corynebacterium glutamicicum (234 FT aa), FASTA scores: opt: 729, E(): 0, (56.0% identity in 209 FT aa overlap); etc. Also similar to Rv2361c|MTCY27.19 (296 FT aa) (35.6% identity in 233 aa overlap). Contains PS01066 FT Uncharacterized protein family UPF0015 signature. SEEMS TO FT BELONG TO THE UPP SYNTHETASE FAMILY." FT /db_xref="GOA:Q7U0P8" FT /db_xref="InterPro:IPR018520" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0P8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93975.1" FT /translation="MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRW FT ARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEII FT TDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRRE FT IVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFL FT LWQSAYSEMWFTEAHWPAFRHVDFLRALRDYSARHRRYGR" FT CDS 225920..228244 FT /transl_table=11 FT /gene="PE_PGRS21" FT /locus_tag="Mb1116" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1116, PE_PGRS21, len: 774 aa. Similar to Rv1087, FT len: 767 aa, from Mycobacterium tuberculosis strain H37Rv, FT (96.8% identity in 783 aa overlap). Member of the M. FT tuberculosis PE family, PGRS subfamily of gly-rich FT proteins. Similar to Rv1090|AL021897|MTV017_43 FT Mycobacterium tuberculosis H37Rv (853 aa), FASTA scores: FT opt: 2819, E(): 0, (59.8% identity in 860 aa overlap). FT Contains PS00583 pfkB family of carbohydrate kinases FT signature 1 near C -terminus. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT insertions of 3 bp (*-gcg) and 45 bp, and deletions of 18 FT bp and 9 bp (ggtggggcc-*), lead to a longer product FT compared to the homolog in Mycobacterium tuberculosis FT strain H37Rv (774 aa versus 767 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0P7" FT /protein_id="CAD93976.1" FT /translation="MSFVVVAPEVLAAAASDLAGIGSTLAQANAAALAPTTAVLAAGAD FT EVSAAIASLFGAHGQAYQAVSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVEQD FT LLAAINARFERIFGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTVGMAGGNGGAA FT GLIGNGGFGGGGGPGAAGGNGGAGGWLFGNGGAGGAGGLGVAPGVPGGAGGAGGAGGVG FT GPAGLWGHGGAGGAGGAGVAGAGGFEGTIGAGGAGGVGGAGGVGGAGGAGGWLYGDAGA FT GGDGGVGGAGGTGGLGNRGGAGGAGGAGGVGGAGGAAGLWGGGGAGGVGGTGGGAGLGA FT QSVTFSSSLSGLSGGDGGAGGAGGAGGAGGTGGWLYGGGGAAGSGGDGGTGGQGGAGGA FT GVFSLFGSGGGPGGNGGVGGVGGVGGAGGRAGLFGVGGLGGAGGDAGDSGEGGFGGPGL FT AGGLFGNPGNGGVGGIGGDAAAGGAGGAGGNGGWLFGNGGAGGSGGDGGAAGRGGAGNL FT GSAGGINAPAGNPGSGSVGIGGAGGAGGTAGLFGDGGAGGAGAAGGFGGISAATPSAGS FT EGAMGGAGGVGGNARLLGTGGAGGVGGGGGAGGDGGRGGVATPGGQGGDAGDGGAGGAG FT GNGGGGASGAGGWLLGTGGAGGAGGNGGNGGKAGFSPGPTNFGLNGAGGGGGVGGNGAT FT GPWLFGDGGAGGGGGAGGIGGDGGPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVP FT NGSGGAGGLSGLLFGEPGANG" FT CDS 228421..228741 FT /transl_table=11 FT /gene="Mb1116A" FT /locus_tag="Mb1116A" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1116A, -, len: 106 aa. Equivalent to Rv1087A, len: FT 106 aa (fragment), from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 106 aa overlap). Conserved FT hypothetical protein, highly similar to C-terminus of near FT ORF O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 SHORT (C15) FT CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE from Mycobacterium FT tuberculosis (262 aa), FASTA scores: opt: 200, E(): FT 1.1e-06, (57.9% identity in 76 aa overlap)." FT /db_xref="GOA:Q7U0P6" FT /db_xref="HSSP:1F75" FT /db_xref="InterPro:IPR001441" FT /db_xref="UniProtKB/TrEMBL:Q7U0P6" FT /protein_id="CAD93977.1" FT /translation="MPCVGYGDRREFVDAVAVEAICENLNTSGQPDPDLVIRTSGEQRL FT SGHRGPTGGVSRRRLLRALRDYSTPHASIPYVPPPYRSDGIHASRLAVESVFDALAGRV FT EL" FT CDS 228894..229328 FT /transl_table=11 FT /gene="PE9" FT /locus_tag="Mb1117" FT /product="PE FAMILY PROTEIN" FT /note="Mb1117, PE9, len: 144 aa. Equivalent to Rv1088, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 144 aa overlap). Member of Mycobacterium FT tuberculosis PE family, similar to many others e.g. FT Z96071|MTCI418B_6 Mycobacterium tuberculosis cosmid (487 FT aa), FASTA scores: opt: 318, E(): 7.3e-14, (60.9% identity FT in 87 aa overlap) - except it appears to be frameshifted FT around codon 84. No error to account for frameshift could FT be found." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0P5" FT /protein_id="CAD93978.1" FT /translation="MSYMIATPAALTAAATDIDGIGSAVSVANAAAVAATTGVLAAGGD FT EVLAAIARLFNANAEEYHALSAQVAAFQTLFVRTLTGGCGVFRRRRGRQCVTAAEHRAA FT GAGRRQRRRRSGDGQWRLRQQRHFGCGGQPEFRQHSEHRR" FT CDS 229207..229512 FT /transl_table=11 FT /gene="PE10" FT /locus_tag="Mb1118" FT /product="PE FAMILY PROTEIN" FT /note="Mb1118, PE10, len: 101 aa. Equivalent to Rv1089, FT len: 120 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 101 aa overlap). Member of the FT Mycobacterium tuberculosis PE family of glycine-rich FT proteins. Partial ORF that appears to be frameshifted, FT continuation of Rv1088|MTV017.41. Sequence has been checked FT and appears correct. Similar to Z95555|MTCY06F7_4 FT Mycobacterium tuberculosis cosmid (401 aa), FASTA scores: FT opt: 126, E(): 2, (29.6% identity in 125 aa overlap)." FT /db_xref="GOA:Q7U0P4" FT /db_xref="InterPro:IPR001919" FT /db_xref="UniProtKB/TrEMBL:Q7U0P4" FT /protein_id="CAD93979.1" FT /translation="MRGAVNAVAGQVTGNGGSGNSGTSAAAANPNSDNTASIADRGTSA FT IMTTASATASSTGVDGGIAATYAVASQWDGGYVANYTITQFGRDFDDRLAVAIHFA" FT CDS 229898..230002 FT /transl_table=11 FT /gene="celA2a" FT /locus_tag="Mb1119" FT /product="PROBABLE CELLULASE CELA2A FT (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL FT CELLULASE)" FT /EC_number="3.2.1.4" FT /note="Mb1119, celA2a, len: 34 aa. Equivalent to Rv1089A, FT len: 34 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 34 aa overlap). Probable celA2a, first FT part of cellulase (endoglucanase) (EC 3.2.1.4), similar to FT N-terminus of others." FT /db_xref="GOA:Q7U0P3" FT /db_xref="UniProtKB/TrEMBL:Q7U0P3" FT /protein_id="CAD93980.1" FT /translation="MNGAAPTNGAPLSYPSICEGVHWGHLVGGHQPAY" FT CDS 229980..230435 FT /transl_table=11 FT /gene="celA2b" FT /locus_tag="Mb1120" FT /product="PROBABLE CELLULASE CELA2B FT (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL FT CELLULASE)" FT /EC_number="3.2.1.4" FT /note="Mb1120, celA2b, len: 151 aa. Equivalent to Rv1090, FT len: 151 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 151 aa overlap). Probable celA2b, second FT part of cellulase (endoglucanase) (EC 3.2.1.4), similar to FT C-terminus of others e.g. O08468 cellulase CEL2 from FT Streptomyces halstedi (377 aa), FASTA scores: opt: 554, FT E(): 1.2e-30, (52.0% identity in 152 aa overlap); etc. Gene FT appears to have been inactivated by frameshift mutations FT but no errors could be found that would account for this." FT /db_xref="GOA:Q7U0P2" FT /db_xref="HSSP:1H0B" FT /db_xref="InterPro:IPR002594" FT /db_xref="UniProtKB/TrEMBL:Q7U0P2" FT /protein_id="CAD93981.1" FT /translation="MGTNLPTEVGQILSAPTSIDYNYPTTGVWDASYDICLDSTPKTTG FT VNQQEIMIWFNHQGSIQPVGSPVGNTTIEGKNFVVWDGSNGMNNAMAYVATEPIEVWSF FT DVMSFVDHTATMEPITDSWYLTSIRAGLEPWSDGVGLGVDSFSAKVN" FT CDS 230850..233402 FT /transl_table=11 FT /gene="PE_PGRS22" FT /locus_tag="Mb1121" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb1121, PE_PGRS22, len: 850 aa. Equivalent to FT Rv1091, len: 853 aa, from Mycobacterium tuberculosis strain FT H37Rv, (99.6% identity in 853 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins. Similar to Rv1087|AL021897|MTV017_39 FT Mycobacterium tuberculosis H37Rv (767 aa), FASTA scores: FT opt: 2819, E(): 0, (60.0% identity in 860 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 FT bp deletion (ccggcggca-*) leads to a shorter product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (850 aa versus 853 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U0P1" FT /protein_id="CAD93982.1" FT /translation="MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALLAAGAD FT EVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAAEAANVSAAQSTDQR FT LLDLINGPTQALLGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAA FT GLIGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIPGVAGGNGGAGGSAGLW FT GTGGAGGDGGNGRSGPVNVAGSAGGNGGAGGAAGLFGDAGAGGNGGKGGAGGAAFSINF FT TAGDGGAGGAGGSGGHALLWGAGGAGGNGGSGGTGGAGGSTAGAGGNGGAGGGGGTGGL FT LFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGGAGGDGGAGGAGGNARLWGVGGA FT GGAGGDGGAGGAGGKGGSGLSGNANGGAGGDSGRGGTGGAGGEGGAAGLLVGTGGHGGD FT GGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGGSGGDGGGGAAGPAGWLFGDGGAGG FT NGGAAAAGGAGGQAGGGGGNGGNGGNGGNGGNGGNGATGGWLYGNGGAGGQGATAGAGG FT AGANGVSSTNGGGNGGIGGTGGSGGAGGNAGLLGVGGAGGHGASGGAGDRGGAGGTGFI FT SSDGGAGGDGGDGGNGGAGGTGGLLFGAGGNGGPGGSGGAADIGGNGGAGNGGGTDGNG FT GNGGSGGGAGSGGDGGGAGGNGAWLFGNGGAGGGGGKGGNGAGGGLGGGSFGLPGLNGS FT GGDGGDGGNGAPGGVLYGNGGAGGQGSSGGIGGPGATGGAGGKGGDGGDAQLIGDGGNG FT GNGGAGGTGGTPGPGGPGGSGGLGGLLFGQTGTAGVSP" FT CDS complement(233620..234558) FT /transl_table=11 FT /gene="coaA" FT /locus_tag="Mb1122c" FT /product="Probable pantothenate kinase coaA (Pantothenic FT acid kinase)" FT /EC_number="2.7.1.33" FT /note="Mb1122c, coaA, len: 312 aa. Equivalent to Rv1092c, FT len: 312 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 312 aa overlap). Probable coaA, FT pantothenate kinase (EC 2.7.1.33), similar to many e.g. FT P15044|COAA_ECOLI Escherichia coli (316 aa), FASTA scores FT :opt: 1079, E(): 0, (52.7% identity in 311 aa overlap). FT Equivalent to AL049491|MLCB1222_17 Mycobacterium leprae FT (312 aa) (93.6% identity in 312 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). TBparse FT score is 0.912. BELONGS TO THE PANTOTHENATE KINASE FAMILY." FT /db_xref="GOA:P63811" FT /db_xref="HSSP:1ESM" FT /db_xref="InterPro:IPR004566" FT /db_xref="UniProtKB/Swiss-Prot:P63811" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93983.1" FT /translation="MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQID FT LLEVEEVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVGKS FT TTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNRRALMRFVT FT SVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNVLQTGPTLMVSDLFDFSL FT YVDARIEDIEQWYVSRFLAMRTTAFADPESHFHHYAAFSDSQAVVAAREIWRTINRPNL FT VENILPTRPRATLVLRKDADHSINRLRLRKL" FT CDS 234946..236226 FT /transl_table=11 FT /gene="glyA1" FT /locus_tag="Mb1123" FT /standard_name="glyA" FT /product="Probable Serine hydroxymethyltransferase 1 glyA1" FT /EC_number="2.1.2.1" FT /note="Mb1123, glyA1, len: 426 aa. Equivalent to Rv1093, FT len: 426 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 426 aa overlap). Probable glyA1, serine FT hydroxymethyltransferase 1 (EC 2.1.2.1), equivalent to FT AL049491|MLCB1222_16 from Mycobacterium leprae (426 aa), FT FASTA score: (89.9 % identity in 426 aa overlap). Also FT similar to many e.g. P34895|GLYA_HYPME HYPHOMICROBIUM FT METHYLOVORUM (434 aa), FASTA scores: opt: 1492, E(): 0, FT (56.8% identity in 419 aa overlap); etc. BELONGS TO THE FT SHMT FAMILY. Note that previously known as glyA." FT /db_xref="GOA:P59953" FT /db_xref="InterPro:IPR019798" FT /db_xref="UniProtKB/Swiss-Prot:P59953" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93984.1" FT /translation="MSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFAPRAVLQAQG FT SVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLH FT ALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEF FT RPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVS FT TTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFAD FT RQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEV FT GITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVS FT ALKDRATRLARAFPLYDGLEEWSLVGR" FT CDS 236331..237158 FT /transl_table=11 FT /gene="desA2" FT /locus_tag="Mb1124" FT /product="POSSIBLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE FT DESA2 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE)" FT /EC_number="1.14.19.2" FT /note="Mb1124, desA2, len: 275 aa. Equivalent to Rv1094, FT len: 275 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 275 aa overlap). Possible desA2, FT acyl-[acyl-carrier protein] desaturase (stearoyl-ACP FT desaturase) (EC 1.14.19.2), equivalent to FT AL049491|MLCB1222_15 from Mycobacterium leprae (275 aa), FT FASTA score: (78.1% identity in 274 aa overlap). Also FT weakly similar to plant stearoyl-acyl carrier protein FT desaturases, and very similar to U49839|MTV043.16C|Rv0824c FT enzyme desA1 from Mycobacterium tuberculosis (338 aa), FT FASTA scores: opt: 525, E(): 8.5e-30, (32.2% identity in FT 270 aa overlap); and to U15182|MLU15182_32 acyl-carrier FT protein desaturase precursor from Mycobacterium leprae (338 FT aa), FASTA scores: opt: 506, E(): 1.9e-28, (34.1% identity FT in 261 aa overlap). TBparse score is 0.894." FT /db_xref="GOA:Q7U0P0" FT /db_xref="InterPro:IPR012348" FT /db_xref="UniProtKB/TrEMBL:Q7U0P0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93985.1" FT /translation="MAQKPVADALTLELEPVVEANMTRHLDTEDIWFAHDYVPFDQGEN FT FAFLGGRDWDPSQSTLPRTITDACEILLILKDNLAGHHRELVEHFILEDWWGRWLGRWT FT AEEHLHAIALREYLVVTREVDPVANEDVRVQHVMKGYRAEKYTQVETLVYMAFYERCGA FT VFCRNLAAQIEEPILAGLIDRIARDEVRHEEFFANLVTHCLDYTRDETIAAIAARAADL FT DVLGADIEAYRDKLQNVADAGIFGKPQLRQLISDRITAWGLAGEPSLKQFVTG" FT CDS 237369..238670 FT /transl_table=11 FT /gene="phoH2" FT /locus_tag="Mb1125" FT /product="PROBABLE PHOH-LIKE PROTEIN PHOH2 (PHOSPHATE FT STARVATION-INDUCIBLE PROTEIN PSIH)" FT /note="Mb1125, phoH2, len: 433 aa. Equivalent to Rv1095, FT len: 433 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 433 aa overlap). Probable phoH2, FT phoH-like protein (phosphate starvation-induced protein), FT probably ATP-binding protein. Equivalent to AL049491 FT MLCB1222_14 Mycobacterium leprae (433 aa) (92.8% identity FT in 432 aa overlap). Similar to many proteins described as FT PhoH-like e.g. Z97025|BSZ97025_12 Bacillus subtilis (442 FT aa), FASTA scores: opt: 605, E(): 0, (40.1% identity in 444 FT aa overlap); or Mycobacterium tuberculosis FT Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352 FT aa), FASTA scores: opt: 390, E(): 4e-19, (31.5% identity in FT 241 aa overlap). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). BELONGS TO THE PHOH FAMILY." FT /db_xref="GOA:Q7U0N9" FT /db_xref="InterPro:IPR006596" FT /db_xref="UniProtKB/TrEMBL:Q7U0N9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93986.1" FT /translation="MTDTRTYVLDTSVLLSDPWACSRFAEHDVVVPLVVISELEAKRHH FT HELGWFARQALRLFDDLRLEHGRLDQPIPVGTQGGTLHVELNHTDPAVLPAGFRTDSND FT SRILSCAANLAAEGKRVTLVSKDIPLRVKAAAVGLAADEYHAQDVVVSGWSGMHELETA FT SADIDALFADGEIDLVEARDLPCHTGIRLLGGGSHALGRVNAHKRVQLVRGDREAFGLR FT GRSAEQRVALDLLLDESVGIVSLGGKAGTGKSALALCAGLEAVLERRTHRKVVVFRPLY FT AVGGQELGYLPGSESEKMGPWAQAVFDTLEGLASPAVLEEVLSRGMLEVLPLTHIRGRS FT LHDSFVIVDEAQSLERNVLLTVLSRLGTGSRVVLTHDIAQRDNLRVGRHDGVAAVIEKL FT KGHPLFAHITLLRSERSPIAALVTEMLEEITGPR" FT CDS 238757..239632 FT /transl_table=11 FT /gene="Mb1126" FT /locus_tag="Mb1126" FT /product="POSSIBLE GLYCOSYL HYDROLASE" FT /EC_number="3.-.-.-" FT /note="Mb1126, -, len: 291 aa. Equivalent to Rv1096, len: FT 291 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 291 aa overlap). Possible glycosyl FT hydrolase (EC 3.-.-.-), possibly a deacetylase or esterase. FT Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae FT (291 aa) (81.3% identity in 289 aa overlap). Similar at the FT C-terminus of enzymes involved in carbohydrate degradation FT including Z99110|BSUB0007_92 endo-1,4-beta-xylanase homolog FT yjeA from Bacillus subtilis (467 aa), FASTA scores: opt: FT 418, E(): 2.6e-17, (38.6% identity in 184 aa overlap); FT M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces FT lividans (335 aa), FASTA scores: opt: 371, E(): 1.1e-14, FT (31.6% identity in 237 aa overlap); NP_345933.1|NC_003028 FT peptidoglycan N-acetylglucosamine deacetylase A from FT Streptococcus pneumoniae (463 aa); etc. Has possible FT N-terminal signal sequence with TMhelix at aa 13-31." FT /db_xref="GOA:Q7U0N8" FT /db_xref="InterPro:IPR002509" FT /db_xref="UniProtKB/TrEMBL:Q7U0N8" FT /protein_id="CAD93987.1" FT /translation="MPKRPDNQTWRYWRTVTGVVVAGAVLVVGGLSGRVTRAENLSCSV FT IKCVALTFDDGPGPYTDRLLHILTDNDAKATFFLIGNKVAANPAGARRIADAGMEIGSH FT TWEHPNMTTIPPEDIPGQFSRANDVIAAATGRTPTLYRPAGGLSNDAVRQAAAKVGQAE FT ILWDVIPFDWINDSNTAATRHMLMTQIKPGSVVLFHDTYSSTVDVVYQFIPVLKANGYR FT LVTVSELLGPRAPGSSYGSRENGPPVNELRDIPASEIPPLPNTSSPKPMSNFPITDIAG FT QNSGGPNNGA" FT CDS complement(239635..240516) FT /transl_table=11 FT /gene="Mb1127c" FT /locus_tag="Mb1127c" FT /product="PROBABLE MEMBRANE GLYCINE AND PROLINE RICH FT PROTEIN" FT /note="Mb1127c, -, len: 293 aa. Equivalent to Rv1097c, len: FT 293 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 293 aa overlap). Probable membrane Gly-, FT Pro-rich protein, similar to Mycobacterium tuberculosis FT Rv2507|MTCY07A7. 13|Z95556 (273 aa), FASTA scores: opt: FT 219, E(): 0.023, (30.5% identity in 266 aa overlap); and FT Rv2507. Contains potential membrane spanning region (aa FT ~68-92). TBparse score is 0.912." FT /db_xref="UniProtKB/TrEMBL:Q7U0N7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93988.1" FT /translation="MTVPPAGPYGNYPYGPNTYGQDLYWGGQPQGGSYPPAYPPQQYPP FT GWPAGPYPPGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPATS FT APTSQPFSQQTATGCTPNVSGGVQPIGDSISAGKLSFPTSAAPGWSAFSDDQNPNLIDA FT VGVGHEVAGADQWMMQAEVAITNFVTTMDVAAQASKLMQCVADGPGYAGSSPTLGPTKT FT SSITVDGVRAARVDADITIADSSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSRATV FT ERVIEALKVNKS" FT CDS complement(240513..241937) FT /transl_table=11 FT /gene="fum" FT /locus_tag="Mb1128c" FT /product="PROBABLE FUMARASE FUM (Fumarate hydratase)" FT /EC_number="4.2.1.2" FT /note="Mb1128c, fum, len: 474 aa. Equivalent to Rv1098c, FT len: 474 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100% identity in 474 aa overlap). Probable fum, fumarase FT (EC 4.2.1.2). Equivalent to AL049491|MLCB1222_11 FT Mycobacterium leprae (474 aa) (89.5 % identity in 467 aa FT overlap). Similar to many e.g. P14408|FUMH_RAT FUMARATE FT HYDRATASE, MITOCHONDRIAL PRECURSOR from Rattus norvegicus FT (507 aa), FASTA scores: opt: 1427, E(): 0, (52.3% identity FT in 461 aa overlap); and P05042|FUMC_ECOLI Fumarate FT hydratase class II from Escherichia coli (467 aa), FASTA FT scores: opt: 1355, E(): 0, (50.2% identity in 444 aa FT overlap). Contains PS00163 Fumarate lyases signature. FT TBparse score is 0.886." FT /db_xref="GOA:Q7U0N6" FT /db_xref="InterPro:IPR000362" FT /db_xref="UniProtKB/Swiss-Prot:Q7U0N6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93989.1" FT /translation="MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG FT LERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGS FT GTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPAL FT QQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLG FT ELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGAL FT RTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQV FT IGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLR FT RLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRL FT DVLAMAKAEQLDSDRL" FT CDS complement(241968..242954) FT /transl_table=11 FT /gene="Mb1129c" FT /locus_tag="Mb1129c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1129c, -, len: 328 aa. Equivalent to Rv1099c, len: FT 328 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 328 aa overlap). Conserved hypothetical FT protein, highly similar to P44811|GLPX_HAEIN GLPX PROTEIN FT HOMOLOG (believed to be involved in glycerol metabolism) FT (333 aa), FASTA scores: opt: 763, E():0, (46.2% identity in FT 327 aa overlap); and Q03224|YWJI_BACSU hypothetical protein FT from Bacillus subtilis (321aa ), FASTA scores: opt: 1092, FT E(): 0, (52.1% identity in 313 aa overlap). Equivalent to FT AL049491|MLCB1222_10 Mycobacterium leprae (355 aa), (93.0% FT identity in 328 aa overlap)." FT /db_xref="GOA:Q7U0N5" FT /db_xref="InterPro:IPR004464" FT /db_xref="UniProtKB/TrEMBL:Q7U0N5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93990.1" FT /translation="MELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRG FT VVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGTTLMSKGMTNAISVLAVADRG FT TMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKDLSVRDMTVCILDRPRHA FT QLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGA FT IQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPG FT GCTTHSIVMRSKSGTVRMIEAYHRLSKLNEYSAIDFTGDSSAVYPLP" FT CDS 243055..243756 FT /transl_table=11 FT /gene="Mb1130" FT /locus_tag="Mb1130" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1130, -, len: 233 aa. Equivalent to Rv1100, len: FT 233 aa, from Mycobacterium tuberculosis strain H37Rv, (100% FT identity in 233 aa overlap). Conserved hypothetical FT protein, slightly similar to Rv1906c|MTCY180.12 FT hypothetical protein from Mycobacterium tuberculosis (156 FT aa), FASTA scores: opt: 122, E(): 6.9, (27.4% identity in FT 135 aa overlap). Equivalent to AL049491|MLCB1222_9 FT Mycobacterium leprae (257 aa) (63.8% identity in 257 aa FT overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U0N4" FT /protein_id="CAD93991.1" FT /translation="MVGDCPRSRTVRWSWDTGHVTAEPQPTPRPAKPRLLQDGRDMFWS FT LAPLVVGCILLAGLVGMCSFQLGGTKRGPIPSYDAAQALRADAKTLGFPIRLPQLPGGW FT TPNSGGRGGIENGRADPATGQRRNAATSIVGFISPTGRYLSLTQSNADEDKLVGSIHPS FT MYPTGTVDVGGTRWVVYEGSDENGAVEPVWTTRLTGPGGATQLAITGAGSIDQFRTLAS FT ATQSQPPLPAR" FT CDS complement(243763..244791) FT /transl_table=11 FT /gene="Mb1131c" FT /locus_tag="Mb1131c" FT /product="CONSERVED MEMBRANE PROTEIN" FT /note="Mb1131c, -, len: 342 aa. Equivalent to 3' end of FT Rv1101c, len: 385 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.7% identity in 342 aa overlap). Conserved FT membrane protein, shows some similarity to other bacterial FT proteins e.g. P77406|PERM_ECOLI PUTATIVE PERMEASE PERM from FT Escherichia coli (353 aa), FASTA scores: opt: 287, E(): FT 8.8e-12, (24.9% identity in 349 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT frameshift due to a single base deletion (t-*) leads to a FT shorter product with a different amino part compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv." FT /db_xref="InterPro:IPR002549" FT /db_xref="UniProtKB/TrEMBL:Q7U0N3" FT /protein_id="CAD93992.1" FT /translation="MFTPLFKWFTKRFNTGLSAACTLLSALAAVVVPVGALVGLAIVQI FT ARMVDSVADWVRTTDLSTLGDKILQFVNGLFDRVPFLHITVTADALRKAMISVAQNVGE FT WLLHFLRDAAGSLAGVITSAIIFVYVFVALLVNREKLRTLIGQLNPLGEDVTDLYLQKM FT GSMVRGTVNGQFVIAACQGVAGAASIYIAGFHHGFFIFAIVLTALSIIPLGGGIVTIPF FT GIGMIFYGNIAGGIFVLLWHLLVVTNIDNVLRPILVPRDARLNSALMLLSVFAGITMFG FT PWGIIIGPVLMILIVTTIDVYLAVYKGVELEQFDAPPVRRRWLPRRGPATSRNAPPPST FT AE" FT CDS complement(245031..245342) FT /transl_table=11 FT /gene="Mb1132c" FT /locus_tag="Mb1132c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb1132c, -, len: 103 aa. Equivalent to Rv1102c, len: FT 103 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.0% identity in 103 aa overlap). Conserved hypothetical FT protein, similar to Mycobacterium tuberculosis hypothetical FT protens e.g. Rv1942c|MTCY9F9_22 (109 aa), FASTA scores: FT opt: 158, E(): 3.6e-05, (33.3% identity in 93 aa overlap); FT Rv0659c|MTCI376_17 (102aa), opt: 140, E(): 0.00072, (40.6% FT i |