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EBI DbfetchID BX248335; SV 1; linear; genomic DNA; STD; PRO; 324050 BP. XX AC BX248335; XX DT 10-JUN-2003 (Rel. 76, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 2/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-324050 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF00059; TPP. XX FH Key Location/Qualifiers FH FT source 1..324050 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS 132..2027 FT /transl_table=11 FT /gene="Mb0290" FT /locus_tag="Mb0290" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0290, -, len: 631 aa. Equivalent to Rv0282, len: FT 631 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 631 aa overlap). Conserved hypothetical FT protein, similar to Y14967|MLCB628.18c hypothetical protein FT from Mycobacterium leprae (573 aa), FASTA scores: opt: 916, FT E(): 0, (38.7% identity in 568 aa overlap). Also similar to FT Mycobacterium tuberculosis proteins e.g. Z94121|MTY15F10.26 FT (619 aa), FASTA scores: opt: 743, E(): 0, (29.9% identity FT in 612 aa overlap). Member of CFXQ, CBXP family - 9 members FT in Mycobacterium tuberculosis. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7U2D3" FT /db_xref="InterPro:IPR003959" FT /db_xref="UniProtKB/TrEMBL:Q7U2D3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93154.1" FT /translation="MAGVGAGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFATCC FT RALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQSIGVLEAASRTAT FT TAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFHLAYAAALASTGGPEEFAKANHV FT VSGITERRAGWRAARWLAVVINYRAERWSDVVKLLTPMVNDPDLDEAFSHAAKITLGTA FT LARLGMFAPALSYLEEPDGPVAVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPEN FT EQVEQALSDTSFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALLHEAELQ FT LAEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGKTTIARVVA FT KIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVATGA FT KNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRNIDFPSYTS FT HELVEIAHKMAEQRDSVFEQSALHDLEALFAKLAAESTPDTNGISRRSLDIAGNGRFVR FT NIVERSEEEREFRLDHSEHAGSGEFSDEELMTITADDVGRSVEPLLRGLGLSVRA" FT CDS 2024..3640 FT /transl_table=11 FT /gene="Mb0291" FT /locus_tag="Mb0291" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0291, -, len: 538 aa. Equivalent to Rv0283, len: FT 538 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 538 aa overlap). Possible conserved FT membrane protein, similar to several hypothetical FT mycobacterial proteins e.g. Z94121|MTY15F10_16|Rv3895c from FT Mycobacterium tuberculosis (495 aa), FASTA scores: opt: FT 698, E(): 0, (37.6% identity in 492 aa overlap); Rv1782; FT Rv3450c; Rv3869; and Y14967|MLCB628_16|MLCB628.17c from FT Mycobacterium leprae (481 aa), FASTA scores: opt: 672, E(): FT 1.5e-31, (37.2% identity in 506 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="InterPro:IPR007795" FT /db_xref="UniProtKB/TrEMBL:Q7U2D2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93155.1" FT /translation="MTNQQHDHDFDHDRRSFASRTPVNNNPDKVVYRRGFVTRHQVTGW FT RFVMRRIAAGIALHDTRMLVDPLRTQSRAVLMGVLIVITGLIGSFVFSLIRPNGQAGSN FT AVLADRSTAALYVRVGEQLHPVLNLTSARLIVGRPVSPTTVKSTELDQFPRGNLIGIPG FT APERMVQNTSTDANWTVCDGLNAPSRGGADGVGVTVIAGPLEDTGARAAALGPGQAVLV FT DSGAGTWLLWDGKRSPIDLADHAVTSGLGLGADVPAPRIIASGLFNAIPEAPPLTAPII FT PDAGNPASFGVPAPIGAVVSSYALKDSGKTISDTVQYYAVLPDGLQQISPVLAAILRNN FT NSYGLQQPPRLGADEVAKLPVSRVLDTRRYPSEPVSLVDVTRDPVTCAYWSKPVGAATS FT SLTLLAGSALPVPDAVHTVELVGAGNGGVATRVALAAGTGYFTQTVGGGPDAPGAGSLF FT WVSDTGVRYGIDNEPQGVAGGGKAVEALGLNPPPVPIPWSVLSLFVPGPTLSRADALLA FT HDTLVPDSRPARPVSAEGGYR" FT CDS 3637..7629 FT /transl_table=11 FT /gene="Mb0292" FT /locus_tag="Mb0292" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0292, -, len: 1330 aa. Equivalent to Rv0284, len: FT 1330 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1330 aa overlap). Possible conserved FT membrane protein, similar to products of two adjacent FT Mycobacterium leprae genes, MLCB628.16c (744 aa) and FT MLCB628.15c (597 aa); and throughout its length to several FT large Mycobacterium tuberculosis proteins: Rv3447c, Rv3870, FT Rv1784, etc. Y14967|MLCB628_ 15 (744 aa), FASTA scores: FT opt: 942, E(): 0, (33.8% identity in 730 aa overlap); FT Y14967|MLCB628_14 (597 aa), FASTA scores: opt: 613, E(): FT 3.1e-30, (31.7% identity in 615 aa overlap); FT Z94121|MTY15F10_17 (1396 aa), FASTA scores: opt: 652, E(): FT 2.2e-32, (35.4% identity in 1321 aa overlap); FT Z95389|MTCY77_19 (1236 aa), FASTA scores: opt 652, E(): FT 2.2e-32, (35.4% identity in 1321 aa overlap). Contains FT three PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7U2D1" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U2D1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93156.1" FT /translation="MSRLIFEARRRLAPPSSHQGTIIIEAPPELPRVIPPSLLRRALPY FT LIGILIVGMIVALVATGMRVISPQTLFFPFVLLLAATALYRGNDKKMRTEEVDAERADY FT LRYLSVVRDNIRAQAAEQRASALWSHPDPTALASVPGSRRQWERDPHDPDFLVLRAGRH FT TVPLATTLRVNDTADEIDLEPVSHSALRSLLDTQRSIGDVPTGIDLTKVSRITVLGERA FT QVRAVLRAWIAQAVTWHDPTVLGVALAARDLEGRDWNWLKWLPHVDIPGRLDALGPARN FT LSTDPDELIALLGPVLADRPAFTGQPTDALRHLLIVVDDPDYDLGASPLAVGRAGVTVV FT HCSASAPHREQYSDPEKPILRVAHGAIERWQTGGWQPYIDAADQFSADEAAHLARRLSR FT WDSNPTHAGLRSAATRGASFTTLLGIEDASRLDVPALWAPRRRDEELRVPIGVTGTGEP FT LMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSAERLIVIYADFKGEAG FT ADSFRDFPQVVAVISNMAEKKSLADRFADTLRGEVARREMLLREAGRKVQGSAFNSVLE FT YENAIAAGHSLPPIPTLFVVADEFTLMLADHPEYAELFDYVARKGRSFRIHILFASQTL FT DVGKIKDIDKNTAYRIGLKVASPSVSRQIIGVEDAYHIESGKEHKGVGFLVPAPGATPI FT RFRSTYVDGIYEPPQTAKAVVVQSVPEPKLFTAAAVEPDPGTVIADTDEQEPADPPRKL FT IATIGEQLARYGPRAPQLWLPPLDETIPLSAALARAGVGPRQWRWPLGEIDRPFEMRRD FT PLVFDARSSAGNMVIHGGPKSGKSTALQTFILSAASLHSPHEVSFYCLDYGGGQLRALQ FT DLAHVGSVASALEPERIRRTFGELEQLLLSRQQREVFRDRGANGSTPDDGFGEVFLVID FT NLYGFGRDNTDQFNTRNPLLARVTELVNVGLAYGIHVIITTPSWLEVPLAMRDGLGLRL FT ELRLHDARDSNVRVVGALRRPADAVPHDQPGRGLTMAAEHFLFAAPELDAQTNPVAAIN FT ARYPGMAAPPVRLLPTNLAPHAVGELYRGPDQLVIGQREEDLAPVILDLAANPLLMVFG FT DARSGKTTLLRHIIRTVREHSTADRVAFTVLDRRLHLVDEPLFPDNEYTANIDRIIPAM FT LGLANLIEARRPPAGMSAAELSRWTFAGHTHYLIIDDVDQVPDSPAMTGPYIGQRPWTP FT LIGLLAQAGDLGLRVIVTGRATGSAHLLMTSPLLRRFNDLQATTLMLAGNPADSGKIRG FT ERFARLPAGRAILLTDSDSPTYVQLINPLVDAAAVSGETQQKGSQS" FT CDS 7626..7934 FT /transl_table=11 FT /gene="PE5" FT /locus_tag="Mb0293" FT /product="PE FAMILY PROTEIN" FT /note="Mb0293, PE5, len: 102 aa. Equivalent to Rv0285, len: FT 102 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 102 aa overlap). Member of the FT Mycobacterium tuberculosis PE family (see first citation FT below), similar to others e.g. AL0212|MTV012_37 from FT Mycobacterium tuberculosis (105 aa), FASTA scores: opt: FT 497, E(): 2.6e-24, (80.4% identity in 102 aa overlap); FT Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102 FT aa), FASTA scores: opt: 413, E(): 3.7e-19, (66.7% identity FT in 102 aa overlap); etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U2D0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93157.1" FT /translation="MTLRVVPEGLAAASAAVEALTARLAAAHASAAPVITAVVPPAADP FT VSLQTAAGFSAQGVEHAVVTAEGVEELGRAGVGVGESGASYLAGDAAAAATYGVVGG" FT CDS 7937..9478 FT /transl_table=11 FT /gene="PPE4" FT /locus_tag="Mb0294" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0294, PPE4, len: 513 aa. Equivalent to Rv0286, FT len: 513 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 513 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family, similar to others FT e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 FT aa), FASTA scores: opt: 958, E(): 0, (43.5% identity in 522 FT aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7U2C9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93158.1" FT /translation="MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYASTA FT AELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTTAL FT AAMPTLAELAANHVIHTVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAASGA FT ALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQF FT LQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLPA FT GLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAA FT GAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVPAAAAAAA FT TRGQSRARRRRRSELRDYGDEFLDMDSDSGFGPSTGDHGAQASERGAGTLGFAGTATKE FT RRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK" FT CDS 9527..9820 FT /transl_table=11 FT /gene="esxG" FT /locus_tag="Mb0295" FT /standard_name="TB9.8" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB9.8" FT /note="Mb0295, esxG, len: 97 aa. Equivalent to Rv0287, len: FT 97 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 97 aa overlap). esxG, conserved FT hypothetical protein. PE-family related protein; distant FT member of the Mycobacterium tuberculosis PE family, similar FT to Rv3020c|AL0212|MTV012.34 (97 aa), FASTA scores: opt: FT 564, E(): 0, (91.8% identity in 97 aa overlap). Contains FT probable helix-turn-helix motif at aa 14-35 (Score 144, FT +4.11 SD). SEEMS TO BELONG TO THE ESAT6 FAMILY (see third FT citation below)." FT /db_xref="UniProtKB/TrEMBL:Q7U2C8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93159.1" FT /translation="MSLLDAHIPQLVASQSAFAAKAGLMRHTIGQAEQAAMSAQAFHQG FT ESSAAFQAAHARFVAAAAKVNTLLDVAQANLGEAAGTYVAADAAAASTYTGF" FT CDS 9850..10140 FT /transl_table=11 FT /gene="esxH" FT /locus_tag="Mb0296" FT /standard_name="cfp7; TB10.4" FT /product="LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7 CFP7 (10 FT kDa ANTIGEN) (CFP-7) (PROTEIN TB10.4)" FT /note="Mb0296, esxH, len: 96 aa. Equivalent to Rv0288, len: FT 96 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 96 aa overlap). esxH (alternate gene FT name: TB10.4), low molecular weight protein antigen 7 (10 FT kDa antigen) (CFP-7) (Protein TB10.4) (see citations FT below), ala-rich protein; member of mycobacterial protein FT family containing ESAT-6, very similar to MTV012_33 from FT Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 566, FT E(): 0, (84.4% identity in 96 aa overlap). Alternative FT start codon possible position 351878 (see second citation). FT BELONG TO THE ESAT6 FAMILY (see first, sixth and seventh FT citations below)." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:P0A569" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93160.1" FT /translation="MSQIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQG FT DTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAMMARDTAEAAKWGG" FT CDS 10151..11038 FT /transl_table=11 FT /gene="Mb0297" FT /locus_tag="Mb0297" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0297, -, len: 295 aa. Equivalent to Rv0289, len: FT 295 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 295 aa overlap). Conserved hypothetical FT protein, equivalent to CAC32061.1|AL583926 possible FT DNA-binding protein from Mycobacterium leprae (289 aa); and FT showing some similarity to FT Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from FT Mycobacterium tuberculosis (276 aa), FASTA scores: opt: FT 149, E(): 0.0035, (27.7% identity in 289 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2C7" FT /protein_id="CAD93161.1" FT /translation="MDATPNAVELTVDNAWFIAETIGAGTFPWVLAITMPYSDAAQRGA FT FVDRQRDELTRMGLLSPQGVINPAVADWIKVVCFPDRWLDLRYVGPASADGACELLRGI FT VALRTGTGKTSNKTGNGVVALRNAQLVTFTAMDIDDPRALVPILGVGLAHRPPARFDEF FT SLPTRVGARADERLRSGVPLGEVVDYLGIPASARPVVESVFSGPRSYVEIVAGCNRDGR FT HTTTEVGLSIVDTSAGRVLVSPSRAFDGEWVSTFSPGTPFAIAVAIQTLTACLPDGQWF FT PGQRVSRDFSTQSS" FT CDS 11085..12503 FT /transl_table=11 FT /gene="Mb0298" FT /locus_tag="Mb0298" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0298, -, len: 472 aa. Equivalent to Rv0290, len: FT 472 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 472 aa overlap). Probable conserved FT transmembrane protein, similar to several others in FT mycobacteria e.g. Z95389|MTCY77_20|Rv3887c from FT Mycobacterium tuberculosis (467 aa), FASTA scores: opt: FT 429, E(): 5.1e-19, (28. 6% identity in 479 aa overlap); FT Rv3877; Rv1795; Rv3448; and Y14967|MLCB628_9|MLCB628.10c FT from Mycobacterium leprae (480 aa), FASTA scores: opt: 269, FT E(): 3.1e-09, (26.0% identity in 503 aa overlap). TBparse FT score is 0.892." FT /db_xref="GOA:Q7U2C6" FT /db_xref="InterPro:IPR006707" FT /db_xref="UniProtKB/TrEMBL:Q7U2C6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93162.1" FT /translation="MSGTVMQIVRVAILADSRLTEMALPAELPLREILPAVQRLVVPSA FT QNGDGGQADSGAAVQLSLAPVGGQPFSLDASLDTVGVVDGDLLVLQPVPAGPAAPGIVE FT DIADAAMIFSTSRLKPWGIAHIQRGALAAVIAVALLATGLTVTYRVATGVLAGLLAVAG FT IAVASALAGLLITIRSPRSGIALSIAALVPIGAALALAVPGKFGPAQVLLGAAGVAAWS FT LIALMIPSAERERVVAFFTAAAVVGASVALAAGAQLLWQLPLLSIGCGLIVAALLVTIQ FT AAQLSALWARFPLPVIPAPGDPTPSAPPLRLLEDLPRRVRVSDAHQSGFIAAAVLLSVL FT GSVAIAVRPEALSVVGWYLVAATAAAATLRARVWDSAACKAWLLAQPYLVAGVLLVFYT FT TTGRYVAAFGAVLVLAVLMLAWVVVALNPGIASPESYSLPLRRLLGLVAAGLDVSLIPV FT MAYLVGLFAWVLNR" FT CDS 12500..13885 FT /transl_table=11 FT /gene="Mb0299" FT /locus_tag="Mb0299" FT /product="PROBABLE PROTEASE PRECURSOR" FT /EC_number="3.4.-.-" FT /note="Mb0299, -, len: 461 aa. Equivalent to Rv0291, len: FT 461 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 461 aa overlap). Probable protease FT precursor (EC 3.4.-.-), similar to several others in FT mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from FT Mycobacterium tuberculosis (446 aa), FASTA scores: opt: FT 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; FT Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from FT Mycobacterium leprae (446 aa), FASTA scores: opt: 1159, FT E(): 0, (43.5 identity in 446 aa overlap). Has signal FT sequence and hydrophobic stretch at C-terminus, followed by FT short positively charged segment, that could act as FT membrane anchor. Shows similarity to several members of the FT subtilase family and contains PS00137 Serine proteases, FT subtilase family, histidine active site signature." FT /db_xref="GOA:Q7U2C5" FT /db_xref="HSSP:1DBI" FT /db_xref="InterPro:IPR000209" FT /db_xref="UniProtKB/TrEMBL:Q7U2C5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93163.1" FT /translation="MIRAAFACLAATVVVAGWWTPPAWAIGPPVVDAAAQPPSGDPGPV FT APMEQRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQLVAIIDTGVQPGPRL FT PNVDAGGDFVESTDGLTDCDGHGTLVAGIVAGQPGNDGFSGVAPAARLLSIRAMSTKFS FT PRTSGGDPQLAQATLDVAVLAGAIVHAADLGAKVINVSTITCLPADRMVDQAALGAAIR FT YAAVDKDAVIVAAAGNTGASGSVSASCDSNPLTDLSRPDDPRNWAGVTSVSIPSWWQPY FT VLSVASLTSAGQPSKFSMPGPWVGIAAPGENIASVSNSGDGALANGLPDAHQKLVALSG FT TSYAAGYVSGVAALVRSRYPGLNATEVVRRLTATAHRGARESSNIVGAGNLDAVAALTW FT QLPAEPGGGAAPAKPVADPPVPAPKDTTPRNVAFAGAAALSVLVGLTAATVAIARRRRE FT PTE" FT CDS 13882..14877 FT /transl_table=11 FT /gene="Mb0300" FT /locus_tag="Mb0300" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0300, -, len: 331 aa. Equivalent to Rv0292, len: FT 331 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 331 aa overlap). Probable conserved FT transmembrane protein (has two hydrophobic segments at FT N-terminal end), equivalent to CAC32058.1|AL583926 FT conserved membrane protein from Mycobacterium leprae (339 FT aa)." FT /db_xref="GOA:Q7U2C4" FT /db_xref="UniProtKB/TrEMBL:Q7U2C4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93164.1" FT /translation="MNPIPSWPGRGRVTLVLLAVVPVALAYPWQSTRDYVLLGVAAAVV FT IGLFGFWRGLYFTTIARRGLAILRRRRRIAEPATCTRTTVLVWVGPPASDTNVLPLTLI FT ARYLDRYGIRADTIRITSRVTASGDCRTWVGLTVVADDNLAALQARSARIPLQETAQVA FT ARRLADHLREIGWEAGTAAPDEIPALVAADSRETWRGMRHTDSDYVAAYRVSADAELPD FT TLPAIRSRPAQETWIALEIAYAAGSSTRYTVAAACALRTDWRPGGTAPVAGLLPQHGNH FT VPALTALDPRSTRRLDGHTDAPADLLTRLHWPTPTAGAHRAPLTNAVSRT" FT CDS complement(14864..16066) FT /transl_table=11 FT /gene="Mb0301c" FT /locus_tag="Mb0301c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0301c, -, len: 400 aa. Equivalent to Rv0293c, len: FT 400 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 400 aa overlap). Conserved hypothetical FT protein, similar in C-terminal part to FT Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (413 FT aa), FASTA scores: opt: 394, E(): 2.1e-17, (31.1% identity FT in 299 aa overlap). TBparse score is 0.922." FT /db_xref="UniProtKB/TrEMBL:Q7U2C3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93165.1" FT /translation="MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVES FT SAIADVALRTAVASVLSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSFPA FT PTELPKVTSRPASPLTEWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQHWR FT HRDGPRPTLCVIHGFMGSSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFSPFSG FT FGYFTSGLSGFAEAMAQAVYDFRSIVDYLRHIGVDRIALTGISLGGYTSALLASVESRL FT EAVIPNCPVVMPAKLFDEWFPANKLVKLGLRLTNISRDELIAGLAYHGPLNYRPLLPKD FT RRMIITGLGDRMAPPEHAVTLWKQWDRCALHWFPGSHLLHVSQLDYLRRMTVFLQGLMF FT D" FT CDS 16173..16958 FT /transl_table=11 FT /gene="tam" FT /locus_tag="Mb0302" FT /product="PROBABLE TRANS-ACONITATE METHYLTRANSFERASE TAM" FT /EC_number="2.1.1.-" FT /note="Mb0302, tam, len: 261 aa. Equivalent to Rv0294, len: FT 261 aa, from Mycobacterium tuberculosis strain H37Rv FT (100.0% identity in 261 aa overlap). Probable tam, FT trans-aconitate methyltransferase (EC 2.1.1.-), similar to FT others e.g. P76145|TAM_ECOLI|7465793|B64906|B1519 FT TRANS-ACONITATE METHYLTRANSFERASE from Escherichia coli FT strain K12 (252 aa), FASTA scores: opt: 649, E(): 0, (39.3 FT identity in 252 aa overlap). BELONGS TO THE FT METHYLTRANSFERASE SUPERFAMILY." FT /db_xref="GOA:P66886" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P66886" FT /protein_id="CAD93166.1" FT /translation="MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHLTR FT YLARRWPGAVIEALDSSPEMVAAAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWVPE FT HSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGAVVQ FT SPAYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDESWQQFRQ FT ELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG" FT CDS complement(16947..17750) FT /transl_table=11 FT /gene="Mb0303c" FT /locus_tag="Mb0303c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0303c, -, len: 267 aa. Equivalent to Rv0295c, len: FT 267 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 267 aa overlap). Conserved hypothetical FT protein, showing weak similarity with CAC46877.1|AL591790 FT CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti FT (213 aa); and NP_104818.1|14023999|BAB50604.1|AP00300 FT Protein with weak similarity to NodH from Mesorhizobium FT loti (257 aa)." FT /db_xref="InterPro:IPR015124" FT /db_xref="UniProtKB/TrEMBL:Q7U2C2" FT /protein_id="CAD93167.1" FT /translation="MSRAVRPYLVLATQRSGSTLLVESLRATGCAGEPQEFFQYLPSTG FT MAPQPREWFAGVDDDTILQLLDPLDPGTPDTATPVAWREHVRTSGRTPNGVWGGKLMWN FT QTALLQQRAAQLPDRSGDGLRAAIRDVIGNEPVFVHVHRPDVVSQAVSFWRAVQTQVWR FT GHPDPKRDSQAVYHAGAIAHIIRNLRDQENGWRAWFAEEGIDPIDIAYPVLWRNLTAIV FT ASVLDAIGQDPKLAPAPMLERQANQRSDEWVDRYRAEAPRLGLPT" FT CDS complement(17760..19157) FT /transl_table=11 FT /gene="Mb0304c" FT /locus_tag="Mb0304c" FT /product="PROBABLE SULFATASE" FT /EC_number="3.-.-.-" FT /note="Mb0304c, -, len: 465 aa. Equivalent to Rv0296c, len: FT 465 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 465 aa overlap). Probable sulfatase, FT possibly an aryl-/steryl-sulfatase (EC 3.1.6.-) or a FT sulfamidase (sulfohydrolase) (sulphamidase) (EC 3.10.1.-). FT Similar to various hydrolases e.g. FT AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from Mus FT musculus (502 aa); FT NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 FT N-sulfoglucosamine sulfohydrolase (sulfamidase) FT (sulphamidase) from Mus musculus (502 aa); FT AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase FT from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652 FT STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) FT (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC) FT from Homo sapiens (583 aa); ARSB_FELCA|P33727 arylsulfatase FT B precursor (EC 3.1.6.1) (535 aa), FASTA scores: opt: 231, FT E(): 1.7e-08, (30.3% identity in 261 aa overlap). Also FT similarity with 4 others sulfatases in Mycobacterium FT tuberculosis. Contains sulfatases signature 1 (PS00523). FT Note that previously known as atsG." FT /db_xref="GOA:Q7U2C1" FT /db_xref="HSSP:1E33" FT /db_xref="InterPro:IPR000917" FT /db_xref="UniProtKB/TrEMBL:Q7U2C1" FT /protein_id="CAD93168.1" FT /translation="MTSERATGQRENLLIVHWHDLGRYLGVYHHPDVYSPRLDRLAAEG FT ILFTRAHATAPLCTPSRGSLFTGRYPQSNGLVGLAHHGWEYRTGVQTLPQLLSESGWYS FT ALFGMQHETSYPKRLGFDEFDVSNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGFFET FT HRPYPHERYRPADSAAVELPDYLPDTPEVRQDVAEFYGSIATADEAVGRLLDTLADTGL FT DASTWVVFVTDHGPAFPRAKSTLYDAGTGIALIIRPPTRRAMAPRVYDELFSGVDLVPT FT LLDLLRLEVPADVEGVSHAPALLAPDTENAAVRDHVYTAKTYHDSFDPIRAIRTKEYSY FT IENYAPRPLLDLPWDIQESPAGMAVAPLVKAPRPQRELYDLRADPTETNNLLAGDDSTQ FT GVAAIAADLAVRLHDWRQRTADVIPSDFAGSRIAERYTETYLRIHRKTPTGRSAIAADR FT GIDEHCS" FT CDS 19336..21156 FT /transl_table=11 FT /gene="PE_PGRS5" FT /locus_tag="Mb0305" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb0305, PE_PGRS5, len: 606 aa. Equivalent to Rv0297, FT len: 591 aa, from Mycobacterium tuberculosis strain H37Rv, FT (97.5% identity in 606 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, highly similar to others e.g. FT Y03A_MYCTU|Q10637 from Mycobacterium tuberculosis (603 aa), FT FASTA scores: opt: 1884, E(): 0, (53.7% identity in 635 aa FT overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a 45 bp in-frame insertion leads to a longer product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (606 aa versus 591 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U2C0" FT /protein_id="CAD93169.1" FT /translation="MSFVIAQPEMIAAAAGELASIRSAINAANAAAAAQTTGVMSAAAD FT EVSTAVAALFSSHAQAYQAASAQAAAFHAQVVRTLTVDAGAYASAEAANAGPNMLAAVN FT APAQALLGRPLIGNGANGAPGTGQAGGDGGLLFGNGGNGGSGAPGQAGGAGGAAGFFGN FT GGNGGDGGAGANGGAGGTAGWFFGFGGNGGAGGIGVAGINGGLGGAGGDGGNAGFFGNG FT GNGGMGGAGAAGVNAVNPGLATPVTPAANGGNGLNLVGVPGTAGGGADGANGSAIGQAG FT GAGGDGGNASTSGGIGIAQTGGAGGAGGAGGDGAPGGNGGNGGSVEHTGATGSSASGGN FT GATGGNGGVGAPGGAGGNGGHVSGGSVNTAGAGGKGGNGGTGGAGGPGGHGGSVLSGPV FT GDSGNGGAGGDGGAGVSATDIAGTGGRGGNGGHGGLWIGNGGDGGAGGVGGVGGAGAAG FT AIGGHGGDGGSVNTPIGGSEAGDGGKGGLGGDGGDGAAGGDGGAGGDGGGRGIFGQFGA FT GGAGGAGGVGGAGGAGGTGGGGGNGGAIFNAGTPGAAGTGGDGGVGGTGAAGGKGGAGG FT SGGVNGATGADGAKGLDGATGGKGNNGNPG" FT CDS 21299..21526 FT /transl_table=11 FT /gene="Mb0306" FT /locus_tag="Mb0306" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0306, -, len: 75 aa. Equivalent to Rv0298, len: 75 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 75 aa overlap). Hypothetical unknown protein." FT /db_xref="GOA:Q7U2B9" FT /db_xref="InterPro:IPR002145" FT /db_xref="UniProtKB/TrEMBL:Q7U2B9" FT /protein_id="CAD93170.1" FT /translation="MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVA FT LRDYTAKTVPALDIDAYAQRVYQANRAAGS" FT CDS 21523..21825 FT /transl_table=11 FT /gene="Mb0307" FT /locus_tag="Mb0307" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0307, -, len: 100 aa. Equivalent to Rv0299, len: FT 100 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.0% identity in 100 aa overlap). Hypothetical unknown FT protein. Equivalent to AAK44536.1 from Mycobacterium FT tuberculosis strain CDC1551 (49 aa) but longer 51 aa." FT /db_xref="UniProtKB/TrEMBL:Q7U2B8" FT /protein_id="CAD93171.1" FT /translation="MIAPGDIAPRRDNEHELYVAVLSNALHRAADTGRVITCPFIPGRV FT PEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPLGNAGVAALREAASVVTALLC" FT CDS 21873..22094 FT /transl_table=11 FT /gene="Mb0308" FT /locus_tag="Mb0308" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0308, -, len: 73 aa. Equivalent to Rv0300, len: 73 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 73 aa overlap). Conserved hypothetical protein, FT similar to Rv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 FT CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium FT tuberculosis (75 aa), FASTA scores: opt: 84, E(): 8.3, FT (39.5% identity in 38 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2B7" FT /protein_id="CAD93172.1" FT /translation="MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARV FT TVTAADLRRLRGAVAGLGDPELMRQAWR" FT CDS 22091..22516 FT /transl_table=11 FT /gene="Mb0309" FT /locus_tag="Mb0309" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0309, -, len: 141 aa. Equivalent to Rv0301, len: FT 141 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 141 aa overlap). Conserved hypothetical FT protein, similar to other hypothetical M. tuberculosis FT proteins e.g. Rv2757c, Rv0229c, Rv2546, etc." FT /db_xref="InterPro:IPR002716" FT /db_xref="UniProtKB/TrEMBL:Q7U2B6" FT /protein_id="CAD93173.1" FT /translation="MTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVG FT FSAECGEIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLLIAA FT TAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA" FT CDS 22652..23284 FT /transl_table=11 FT /gene="Mb0310" FT /locus_tag="Mb0310" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY TETR/ACRR-FAMILY)" FT /note="Mb0310, -, len: 210 aa. Equivalent to Rv0302, len: FT 210 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 210 aa overlap). Probable transcription FT regulatory protein, TetR family, with its N-terminus FT similar to N-terminus of several repressors and regulatory FT proteins of TetR/AcrR family e.g. ACRR_ECOLI|P34000 FT potential acraB operon repressor from Escherichia coli (215 FT aa), FASTA scores: opt: 172, E(): 3.1e-05, (22.7% identity FT in 194 aa overlap). Also similar in N-terminus to FT N-terminus of MTCY07A7.24 hypothetical regulator from FT Mycobacterium tuberculosis FASTA score: (38.7% identity in FT 62 aa overlap). Contains probable helix-turn helix motif FT from aa 35-56 (Score 1728, +5.07 SD)." FT /db_xref="GOA:Q7U2B5" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U2B5" FT /protein_id="CAD93174.1" FT /translation="MGVPAKKKQQQGERSRESILDATERLMATKGYAATSISDIRDACG FT LAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQ FT HPDFLRLFYLLSMERSQDPVVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAE FT LTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET" FT CDS 23281..24189 FT /transl_table=11 FT /gene="Mb0311" FT /locus_tag="Mb0311" FT /product="PROBABLE DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0311, -, len: 302 aa. Equivalent to Rv0303, len: FT 302 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 302 aa overlap). Possible FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT NADPH dehydrogenases and other NADPH oxidoreductases e.g. FT O48741|PORC_ARATH|7488284|T00897 PROTOCHLOROPHYLLIDE FT REDUCTASE C CHLOROPLAST PRECURSOR (EC 1.3.1.33) FT (NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE C) from FT Arabidopsis thaliana (401 aa); Q42850 NADPH DEHYDROGENASE FT (EC 1.6.99. 1) (395 aa), FASTA scores: opt: 347, E(): FT 3.8e-16, (35.4% identity in 319 aa overlap)." FT /db_xref="GOA:Q7U2B4" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U2B4" FT /protein_id="CAD93175.1" FT /translation="MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDPARGRAA FT MEELGEPNRCSVLEVDLASVRSVRSFVETVRTTPLPPIRALVCNAGLQVVSGIAFTDDG FT VEMTFGVNHLGHFALVTGILDWLARPARIVVVSSGTHDPSKHTGMPDPRYTCAADLAHP FT PTDQNTPAEGRRRYTTSKLCNVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLARDYP FT PILRLAYRLLSPMLRVLPFVHSTRVSGEHLAALAVDPRFAGVTGQYFAGAKAIRSSAES FT YDRAKALDLWETSERLLAQVT" FT CDS complement(24197..27640) FT /transl_table=11 FT /gene="PPE5" FT /locus_tag="Mb0312c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0312c, PPE5, len: 1147 aa. Equivalent to 3' end of FT Rv0304c, len: 2204 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.9% identity in 1147 aa overlap). Member FT of the Mycobacterium tuberculosis PE family (PPE, MPTR), FT similar to others e.g. Z95324|MTY13E10_16 from M. FT tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% FT identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from M. FT tuberculosis (734 aa), FASTA scores: opt: 989, E(): 0, FT (42.3% identity in 522 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate FT genes. In Mycobacterium bovis, a frameshift due to a single FT base deletion (g-*) leads to a shorter CDS (Mb0312c) FT equivalent to the 3' end of Rv0304c/PPE5." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7U2B3" FT /protein_id="CAD93176.1" FT /translation="MFNSGDGNIGFFNSGTGNFGIGNTGTGNFGIGNSGSTSTGLFNSG FT DGNTGGFNPGNFNTGNFNTGSFNTGGFNAGNTNTGHFNTGNYNTGIANTGDVSTGAFIS FT GNYSNGILWRGDYQGLIGYSYALTIPEIPAHLDVNIPIDIPITGSFTDLVVDNFTIPII FT GFESFAFSFHIHTEPDIGPIIVPSFVLSVPTFAIAVGGPTTAINISATAGLGPITIPII FT DIPAAPGIGNSTTSPSSGFFNTGAGTASGFGNVGGNTSGLWNLASAASGVSGLLNVGAL FT GSGVANVGNTISGIYNTSPLDLGTPAFGSGLANIAGLLQGGAGTTILDLAGLGNLNVGL FT ANLGGSNFGIGNTGIFNVGFANVGNHNIGLANLGNYSVGFANSGNYHIGIANTGSANIG FT FANTGSGNIGIGLTGTGQIGFGSFNSGSHNIGLFNSGDGNVGFFNSGTGNVGIGNTGTA FT NFGIANSGSFNTGLGNTGSTNTSLFNPGNVNTGVGNTGSINTGSFNTGSTNTGSFNLGD FT HNTGSFNSGDYNTGYFNAGDYNTGVANTGNVNTGAFISGNYSNGFFWRGDYQGLIGLST FT TITIPEIPYRYDLSVPIDIPITGTVVATTPNSFTIPGFQIRVLLGPAAVLVNEMIGPIT FT IDVNQVIAIDSPIQQTISMVGTGGFGPIPIGISIGGTPGFGNSTTGPSSGFFHTGAGHV FT SGFGNFGAGNMSGFGNFGAGNSGFFNAGGLGNSGLLNFGALQSGLANLGNTISGVYNTS FT TLDLATPAFGSGIANIGANLAGLFLDNTGNLTLNFGVANQGGLNAGIGNLGSVNIGFVN FT TGDSNLGIGNLGDLNFGGVNIGGNNIGIANTGIFDIGLANLGSYNIGLANLGDDNLGFG FT NAGSYNIGFANFGSDNLGFANTGSYNIGFANTGNNNIGVGLTGNGQIGIGSLNSGSNNI FT GLFNSGSGNIGFFNSGTGNVGIFNAGTGNFGLANSGGFNTGIGNAGSTNTGVFNPGDLN FT TGSFNPGSFNTGGFNPGSGNTGYLNTGDYNTGVANTGDVDTGAFITGSYSNGFLVSGDY FT QGLIGLPLLGIPVTPGYFNLTGGPSSGFFNSGAGSVSGFVNSGAGLSGYLNTGALGSGV FT ANVGNTISGWLNASALDLATPGFLSGIGNFGTNLAGFFRG" FT CDS complement(27784..33741) FT /transl_table=11 FT /gene="PPE6" FT /locus_tag="Mb0313c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0313c, PPE6, len: 1985 aa. Equivalent to 5' end of FT Rv0305c, len: 963 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 809 aa overlap). Member FT of the Mycobacterium tuberculosis PE family (PPE, MPTR), FT similar to others e.g. Y04H_MYCTU|Q10778 from M. FT tuberculosis (734 aa), FASTA scores: opt: 1340, E(): 0, FT (40.9% identity in 815 aa overlap); Z95324|MTY13E10_16 from FT Mycobacterium tuberculosis (1443 aa), FASTA scores: E(): 0, FT (50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from FT Mycobacterium tuberculosis (734 aa), FASTA scores: opt: FT 989, E(): 0, (42.3% identity in 522 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate FT genes. In Mycobacterium bovis, a single base deletion (t-*) FT resulting in the absence of a stop codon leads to a longer FT product. The second part of this CDS shares homology with FT the 5' end of Rv0304c/PPE5." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7U2B2" FT /protein_id="CAD93177.1" FT /translation="MDFVVSAPEVNSLRMYLGAGSGPMLAAAAAWDGLADELAVAASWF FT GSVTSGLADAAWRGPAAVAMARAVAPYLGWLISATAQAEQAAAQARVAVATFEAARAAT FT VHPAIVAANRAVLVSLVSSNLLGFNAPAIAATEAAYERMWAQDVAAMVGYHAGASAAVS FT ALMPFTQQLKKLAGLSERLTSAAAAAAGPPSAAGFNLGLANVGANNVGNGNVGVFNVGF FT GNLGSYNLGFANLGSDNLGLANLGGHNIGFANTGSNNVGFGNTGSNNVGIGLTGNGQIG FT FGSFNSGSHNIGLFNSGSGNVGLFNSGTGNFGIGNSGTGNFGLGNTGSTNTGWFNTGDV FT NTGGFNPGSYNTGNFNTGNYNTGSFNAGNYNTGYFNTGDYNTGVANTGNVNTGAFIAGN FT YSNGVLWRGDYQGLIGADIALEIPAIPINAQLFSMPIHQVMVMPGSVMTIPGMRLPFTS FT IVPFVVYYGPVELPQSTLTLPTVTITVGGPTTTIDGNLTGMVGGVSIPLIKIPAAPGFG FT NSTTSPSSGFFNAGAGTASGFGNFGGGASGFWNLASATSGLSGFGNVGALGSGVANVGN FT TISGLYNTSTSNLATPAFNSGLLHHSVGTMTLNFGLANVGGNNVGGANAGIFNVGLANL FT GDYNIGFGNLGGDNLGFAHAGSYNIGFANTGSNNLGFANTGDNNIGFANIGSNNIGIGL FT TGSGQIGFGSLNSGSHNIGLFNSGDGNIGLFNSGSGNFGIGNAGTGNWGIGNSGAGNFG FT IGNAGSTNTGLFNSGDLNTGSLNPGSYNTGSVNTGSVNTGGFNAGNYNTGYFNTGDYNT FT GMANTGNINTGAFISGNHSNGLLWRGDNQGLIDLAIGVDIPEIPIVSVDVNIPIHIPIT FT ASFTDIVYSGLDLPPNTAVTVIFFGPVDIDPFTVPVIRITGPTPVVMVGGPTTAINIGA FT TVGVDAINIPIIHIPATPGFGNSTGGLSSGFFNSGAGSASGFGNFGGAASGFMNLVSTT FT SGMSGFLNVGALGSGVANVGNTISGIYNVGTSDLSTPAVNSGLANIGTNIAGLLRDGAG FT TAAINLGLANHGNLNVGFASLGGFNFGGATIGHNNVGIGNTGIFDVGLANLGSYNIGFG FT NLGDDNLGFGNFGSYNIGFGNVGNDNLGFANAGGGNIGFANTGSNNVGFGNTGSNNVGI FT GLTGNGQIGFGSFNSGSGNIGLFNSGSNNIGFFNSGSGNFGIANSGSFNTGIGNTGNTN FT TGLFNSGDVNTGAFNPGSFNTGSFNTGSFNTGGFNPGNTNTGYLNIGNYNTGIANTGDV FT DTGAFITGNYSNGLFLSGDYQGLVGLNLVIDMPLPISLGVNIPIDIPITASAGNITLMG FT VTIPPTGDIVLSSIAGQRAHFGPITIPNITVVGPTTTVAIGGPNTAITITGGGAIRIPL FT ISIPAAPGFGNSTTNPSSGFFNTGAGGASGFGNFGGANSGFWNLASATSGASGLLNVGA FT LGSGLANVGTTVSGFYNTSTSDLATPAFNSGLANISTSIAGLLRDSTGTMVLNLGLANH FT GTLNVGIANLGDYNIGFANLGSANFGSANIGGNNIGGANTGIFDIGLANLGSYNIGFGN FT FGDDNLGFGNLGSYNVGFGNLGNDNLGFANTGSNNIGFANTGSNNIGIGLTGDGQIGFG FT SLNSGSGNIGLFNSGSGNIGFFNSGNGNVGIGNTGTANFGLGNTGSTNTGFFNSGDVNT FT GIGNTGSFNTGSFNPGDSNTGDFNPGSYNTGLGNTGDVDTGAFISGSYSNGFLWSGNYQ FT GLIGLHAALAIPEIALTFGVDIPIHIPINIDAGVVTLQGFSIVAAENNIDFTPIIIPTI FT NITLPTAAITVGGPTTSIGITASAGIGSITIPIIDIPATSGFGNSTTSPSSGFFNSGAG FT SASGFLNVVAGASGISGYLNVGALGSGVTNVGHTVSGFYNASALDLVTPAFASGLMRDG FT MGTMTLNLGLANLGSNNAGFGNTGIFDVGVANLGNYNIGFGNFGDDNLALPT" FT CDS 33944..34615 FT /transl_table=11 FT /gene="Mb0314" FT /locus_tag="Mb0314" FT /product="PUTATIVE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0314, -, len: 223 aa. Equivalent to Rv0306, len: FT 223 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 223 aa overlap). Putative FT oxidoreductase (EC 1.-.-.-), highly similar to FT H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved FT hypothetical protein from Pseudomonas aeruginosa strain FT PAO1 (218 aa); and to other putative oxidoreductases e.g. FT middle part of CAB76073.1|AL157953 putative nitroreductase FT from Streptomyces coelicolor (1212 aa); Q52685|BLUB protein FT involved in cobalamin (vitamin B12) synthesis from FT Rhodobacter capsulatus (206 aa), FASTA scores: opt: 318, FT E(): 2e-15, (35.6% identity in 191 aa overlap)." FT /db_xref="GOA:Q7U2B1" FT /db_xref="InterPro:IPR000415" FT /db_xref="UniProtKB/TrEMBL:Q7U2B1" FT /protein_id="CAD93178.1" FT /translation="MFSAPERRAVYRVIAERRDMRRFVPGGVVSEDVLARLLHAAHAAP FT SVGLMQPWRFIRITDETLKRRIHALVDDERLLTAEALGAREEEFLALKVEGILDCAELL FT VVALCDRRGSYIFGRRTLPQMDLASVSCAIQNLWLAARSEGLGMGWVSLFDPQRLAALL FT AMPADAEPVAILCLGPVPEFPDRPALELDGWAYARPLAEFVSENRWSYPSALATDHHHG FT E" FT CDS complement(34603..35085) FT /transl_table=11 FT /gene="Mb0315c" FT /locus_tag="Mb0315c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0315c, -, len: 160 aa. Equivalent to Rv0307c, len: FT 160 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 160 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2B0" FT /protein_id="CAD93179.1" FT /translation="MAVIVRKWFGLGRLPADLRCQVEAEGLIYLAEYVAVTRRFTGVIP FT GLRASHSIASYVGALAFTEQRVLGTLSMVPKLAGRVVDARWDGPQAGAATAEISPTGLQ FT LDLDVADVDPKFSGQLALHFKATIGEDVLSRLPRRSLAFDVPAEYVNLAVGVTYSP" FT CDS 35143..35859 FT /transl_table=11 FT /gene="Mb0316" FT /locus_tag="Mb0316" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0316, -, len: 238 aa. Equivalent to Rv0308, len: FT 238 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 238 aa overlap). Probable conserved FT integral membrane protein, with C-terminus highly similar FT to C-terminus of other integral membrane proteins or FT phosphatases e.g. FT AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1 FT putative phosphatase from Streptococcus pyogenes (201 aa); FT Q06074 HYPOTHETICAL 24.9 KD PROTEIN (216 aa), FASTA scores: FT opt: 209, E(): 2e-07, (27.9% identity in 140 aa overlap). FT Could be a phosphatase." FT /db_xref="GOA:Q7U2A9" FT /db_xref="InterPro:IPR000326" FT /db_xref="UniProtKB/TrEMBL:Q7U2A9" FT /protein_id="CAD93180.1" FT /translation="MTRPQALLAVSLAFVATAVYAVMWVGHSQDWGWLHSFDWSLLNAA FT HDIGIKNPAWVRFWDGVSLILGPVVLRPLGLLAAMVALAKRKIRIALLLLACLPLNAIM FT TIAAKSVAHRPRPATALVSAHSTSFPSGHALEATASVLALLTVLLPMLHSRFTRHIAIT FT VGALCVLTVGVARVALNVHHPTDVVAGWALGYLYFLVCLCVFRPPSIFGAQRASHALSP FT PVEVSRQPEPEVDTAR" FT CDS 35961..36617 FT /transl_table=11 FT /gene="Mb0317" FT /locus_tag="Mb0317" FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT /note="Mb0317, -, len: 218 aa. Equivalent to Rv0309, len: FT 218 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 218 aa overlap). Possible conserved FT exported protein (has putative N-terminal signal sequence), FT equivalent to AC32053.1|AL583926 putative secreted protein FT from Mycobacterium leprae (218 aa). Also similar to others FT e.g. AB76092.1|AL157956 putative secreted protein from FT Streptomyces coelicolor (238 aa)." FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:Q7U2A8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93181.1" FT /translation="MSRLLALLCAAVCTGCVAVVLAPVSLAVVNPWFANSVGNATQVVS FT VVGTGGSTAKMDVYQRTAAGWQPLKTGITTHIGSAGMAPEAKSGYPATPMGVYSLDSAF FT GTAPNPGGGLPYTQVGPNHWWSGDDNSPTFNSMQVCQKSQCPFSTADSENLQIPQYKHS FT VVMGVNKAKVPGKGSAFFFHTTDGGPTAGCVAIDDATLVQIIRWLRPGAVIAIAK" FT CDS complement(36687..37178) FT /transl_table=11 FT /gene="Mb0318c" FT /locus_tag="Mb0318c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0318c, -, len: 163 aa. Equivalent to Rv0310c, len: FT 163 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 163 aa overlap). Conserved hypothetical FT protein, similar to some bile acid dehydratases e.g. FT P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 FT BILE ACID-INDUCIBLE OPERON PROTEIN E from Eubacterium sp FT (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% FT identity in 134 aa overlap); AAF22847.1|AF210152_4 bile FT acid 7a-dehydratase from Clostridium sp. (168 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U2A7" FT /protein_id="CAD93182.1" FT /translation="MCCNGVVTPGDPADIAAIKQLKYRYLRALDTKHWDDFTDTLAEDV FT TGDYGSSVGTELHFTNRADLVDYLRQALGPGVITEHRVTHPEITVTGDTATGIWYLQDR FT VIVAEFNFMLIGAAFYHDQYRRTTDGWRISATGYDRTYEATMSLAGLNFNIRPGRALAD FT " FT CDS 37202..38431 FT /transl_table=11 FT /gene="Mb0319" FT /locus_tag="Mb0319" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0319, -, len: 409 aa. Equivalent to Rv0311, len: FT 409 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 409 aa overlap). Hypothetical unknown FT protein. Contains PS00881 Protein splicing signature." FT /db_xref="InterPro:IPR018254" FT /db_xref="UniProtKB/TrEMBL:Q7U2A6" FT /protein_id="CAD93183.1" FT /translation="MSQSRYAGLSRSELAVLLPELLLIGQLIDRSGMAWCIQAFGRQEM FT LQIAIEEWAGASPIYTKRMQKALNFEGDDVPTIFKGLQLDIGAPPQFMDFRFTLHDRWH FT GEFHLDHCGALLDVEPMGDDYVVGMCHTIEDPTFDATAIATNPRAQVRPIHRPPRKPAD FT RHPHCAWTVIIDESYPEAEGIPALDAVRETKAATWELDNVDASDDGLVDYSGPLVSDLD FT FGAFSHSALVRMADEVCLQMHLLNLSFAIAVRKRAKADAQLAISVNTRQLIGVAGLGAE FT RIHRAMALPGGIEGALGVLELHPLLNPAGYVLAETSPDRLVVHNSPAHADGAWISLCTP FT ASVQPLQAIATAVDPHLKVRISGTDTDWTAELIEADAPASELPEVLVAKVSRGSVFQFE FT PRRSLPLTVK" FT CDS 38586..40448 FT /transl_table=11 FT /gene="Mb0320" FT /locus_tag="Mb0320" FT /product="CONSERVED HYPOTHETICAL PROLINE AND THREONINE RICH FT PROTEIN" FT /note="Mb0320, -, len: 620 aa. Equivalent to Rv0312, len: FT 620 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 620 aa overlap). Conserved hypothetical FT protein with highly Pro-, Thr-rich C-terminus. Similar to FT Pro-,Thr-rich region in Rv2264c|AL021925|MTV022_14 from FT Mycobacterium tuberculosis (592 aa), FASTA scores: opt: FT 1075, E(): 0, (38.9% identity in 627 aa overlap). Also some FT similarity with Rv0350|dnaK from Mycobacterium FT tuberculosis. Possibly membrane protein; has hydrophobic FT stetch in its middle part." FT /db_xref="GOA:Q7U2A5" FT /db_xref="InterPro:IPR018181" FT /db_xref="UniProtKB/TrEMBL:Q7U2A5" FT /protein_id="CAD93184.1" FT /translation="MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPSQ FT NPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSEIA FT IAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGGVVGL FT LDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDV FT DPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDLIQDPL FT TGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQPGCAAA FT MGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDRELAWSQT FT DFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSAVVAMTAIG FT GVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAPLPSAAPAPT FT TVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTELPVTTTSTIPTIPT FT TTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG" FT CDS 40520..40906 FT /transl_table=11 FT /gene="Mb0321" FT /locus_tag="Mb0321" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0321, -, len: 128 aa. Equivalent to Rv0313, len: FT 128 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 128 aa overlap). Conserved hypothetical FT protein, equivalent only to CAC32049.1|AL583926 conserved FT hypothetical protein from Mycobacterium leprae (130 aa). FT TBparse score is 0.877." FT /db_xref="UniProtKB/TrEMBL:Q7U2A4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93185.1" FT /translation="MGDYGPFGFDPDEFDRVIREGSEGLRDAFERIGRFLSSSGAGTGW FT SAIFEDLSRRSRPAPETAGEAGDGVWAIYTVDADGGARVEQVYATELDALRANKDNTDP FT KRKVRFLPYGIAVSVLDDPVDEAQ" FT CDS complement(40909..41571) FT /transl_table=11 FT /gene="Mb0322c" FT /locus_tag="Mb0322c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0322c, -, len: 220 aa. Equivalent to Rv0314c, len: FT 220 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 220 aa overlap). Possible conserved FT membrane protein, with hydrophobic stretch from residues FT ~75-100. Similar in C-terminal part to Mycobacterium FT tuberculosis proteins Rv0679c and Rv0680c." FT /db_xref="UniProtKB/TrEMBL:Q7U2A3" FT /protein_id="CAD93186.1" FT /translation="MIVVWEHLCMNPEDDPEARIRELERPLADVARASELGGSQSGGYT FT YPPGPPPPPYSYGGPFGGPSPRSSSGNRAWWILAAVVVVGVLVLVGGIAAFSAQRLSQG FT NFVVLSPTPSVSRAVPTPTAQPATTLPPAGASLSVSGVNVNRTIACNDSIVSVSGMSNT FT VVITGHCTSLTVSGMRNSVTADSVDTIEAAGFNNEVTYHSGSPKISNAGGSNSVQQG" FT CDS 41632..42516 FT /transl_table=11 FT /gene="Mb0323" FT /locus_tag="Mb0323" FT /product="POSSIBLE BETA-1,3-GLUCANASE PRECURSOR" FT /EC_number="3.2.1.-" FT /note="Mb0323, -, len: 294 aa. Equivalent to Rv0315, len: FT 294 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 294 aa overlap). Possible FT beta-1,3-glucanase precursor (EC 3.2.1.-) (has hydrophobic FT stretch in its N-terminal part), similar to others e.g. FT Q51333|AAC44371.1 BETA-1,3-GLUCANASE II A from Oerskovia FT xanthineolytica (306 aa), FASTA scores: opt: 76, E(): FT 3e-14, (34.1% identity in 302 aa overlap); and FT AAC38290.1|AF052745 beta-1,3-glucanase II from Oerskovia FT xanthineolytica (435 aa). Contains glycosyl hydrolases FT family 16 active site signature (PS01034)." FT /db_xref="GOA:Q7U2A2" FT /db_xref="InterPro:IPR013320" FT /db_xref="UniProtKB/TrEMBL:Q7U2A2" FT /protein_id="CAD93187.1" FT /translation="MLMPEMDRRRMMMMAGFGALAAALPAPTAWADPSRPAAPAGPTPA FT PAAPAAATGGLLFHDEFDGPAGSVPDPSKWQVSNHRTPIKNPVGFDRPQFFGQYRDSRQ FT NVFLDGNSNLVLRATREGNRYFGGLVHGLWRGGIGTTWEARIKFNCLAPGMWPAWWLSN FT DDPGRSGEIDLIEWYGNGTWPSGTTVHANPDGTAFETCPIGVDGGWHNWRVTWNPSGMY FT FWLDYADGIEPYFSVPATGIEDLNEPIREWPFNDPGYTVFPVLNLAVGGSGGGDPATGS FT YPQEMLVDWVRVF" FT CDS 42565..43179 FT /transl_table=11 FT /gene="Mb0324" FT /locus_tag="Mb0324" FT /product="POSSIBLE MUCONOLACTONE ISOMERASE" FT /EC_number="5.3.3.-" FT /note="Mb0324, -, len: 204 aa. Equivalent to Rv0316, len: FT 204 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 204 aa overlap). Possible muconolactone FT isomerase (EC 5.3.3.-), showing weak similarity with some FT muconolactone isomerases e.g. O33947|CTC1_ACILW FT MUCONOLACTONE DELTA-ISOMERASE 1 (MIASE 1)(96 aa), FASTA FT scores: opt: 179, E(): 3.9e-05, (32.6% identity in 92 aa FT overlap)." FT /db_xref="GOA:Q7U2A1" FT /db_xref="InterPro:IPR003464" FT /db_xref="UniProtKB/TrEMBL:Q7U2A1" FT /protein_id="CAD93188.1" FT /translation="MEFLVTMTTRVPDSMPADAVERVRAREAARSRELAAQGKLLRLWR FT PPLRPGEWRTLGLFAADDNGELEQLLASMPPRSWRTDDVTPLGAHPNDPVGQGITIAPG FT KGPEFLIATTIMVPPGTPAQVVDDTVAREARRAPELAGRGHLVRLWALPDGPDGQRTLG FT LWRARDPGELMAILESLPLAGWMTIETTPLSPHPDDPIRMP" FT CDS complement(43203..43973) FT /transl_table=11 FT /gene="glpQ2" FT /locus_tag="Mb0325c" FT /product="PUTATIVE GLYCEROPHOSPHORYL DIESTER FT PHOSPHODIESTERASE GLPQ2 (GLYCEROPHOSPHODIESTER FT PHOSPHODIESTERASE)" FT /EC_number="3.1.4.46" FT /note="Mb0325c, glpQ2, len: 256 aa. Equivalent to Rv0317c, FT len: 256 aa (start uncertain, chosen by homology), from FT Mycobacterium tuberculosis strain H37Rv, (100.0% identity FT in 256 aa overlap). Possible glpQ2, glycerophosphoryl FT diester phosphodiesterase (EC 3.1.4.46), similar to others FT e.g. E75317|6459876|AAF11631.1|AE002044_4 glycerophosphoryl FT diester phosphodiesterase from Deinococcus radiodurans (285 FT aa); P10908|UGPQ_ECOLI from Escherichia coli (247 aa), FT FASTA scores: opt: 220, E(): 5.2e-07, (28.0% identity in FT 250 aa overlap). Also similar to MTCY01A6.27 from FT Mycobacterium tuberculosis FASTA score: (27.5% identity in FT 247 aa overlap)." FT /db_xref="GOA:Q7U2A0" FT /db_xref="InterPro:IPR004129" FT /db_xref="UniProtKB/TrEMBL:Q7U2A0" FT /protein_id="CAD93189.1" FT /translation="MEFLRHGGRIAMAHRGFTSFRLPMNSMGAFQEAAKLGFRYIETDV FT RATRDGVAVILHDRRLAPGVGLSGAVDRLDWRDVRKAQLGAGQSIPTLEDLLTALPDMR FT VNIDIKAASAIEPTVNVIERCNAHNRVLIGSFSERRRRRALRLLTKRVASSAGTGALLA FT WLTARPLGSRAYAWRMMRDIDCVQLPSRLGGVPVITPARVRGFHAAGRQVHAWTVDEPD FT VMHTLLDMDVDGIITDRADLLRDVLIARGEWDGA" FT tRNA complement(44234..44304) FT /gene="glyU" FT /locus_tag="glyU" FT /note="glyU, len: 71 nt. Equivalent to glyU, len: 71 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 71 nt overlap). tRNA-Gly, anticodon ccc." FT CDS complement(44335..45129) FT /transl_table=11 FT /gene="Mb0326c" FT /locus_tag="Mb0326c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0326c, -, len: 264 aa. Equivalent to Rv0318c, len: FT 264 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 264 aa overlap). Probable conserved FT integral membrane protein, with some similarity to FT C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores: FT opt: 157, E (): 0.0032, (28.3% identity in 198 aa overlap). FT Also similar to O26573 CONSERVED PROTEIN from FT Methanobacterium thermoauto (259 aa), FASTA scores: opt: FT 173, E(): 5.2e-05, (32.7% identity in 214 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U299" FT /protein_id="CAD93190.1" FT /translation="MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILGG FT VVPSVRTPSAAMVSGVQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLVAL FT RRFDGHGEHQDGDDVGELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALTVEV FT LFLGLAVALRLAGSGMPRIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVLAFAA FT AALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYGLGVME" FT CDS 45178..45846 FT /transl_table=11 FT /gene="pcp" FT /locus_tag="Mb0327" FT /product="PROBABLE PYRROLIDONE-CARBOXYLATE PEPTIDASE PCP FT (5-OXOPROLYL-PEPTIDASE) (PYROGLUTAMYL-PEPTIDASE I) (PGP-I) FT (PYRASE)" FT /EC_number="3.4.19.3" FT /note="Mb0327, pcp, len: 222 aa. Equivalent to Rv0319, len: FT 222 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 222 aa overlap). Probable pcp, FT pyrrolidone-carboxylate peptidase (EC 3.4.19.3), highly FT similar to others e.g. PCP_PSEFL|P42673 FT pyrrolidone-carboxylate peptidase from Pseudomonas FT fluorescens (213 aa), FASTA scores: opt: 478, E(): 7.5e-25, FT (40.2% identity in 219 aa overlap). BELONGS TO PEPTIDASE FT FAMILY C15 (THIOL PROTEASE)." FT /db_xref="GOA:P0A5R5" FT /db_xref="HSSP:1IU8" FT /db_xref="InterPro:IPR016125" FT /db_xref="UniProtKB/Swiss-Prot:P0A5R5" FT /protein_id="CAD93191.1" FT /translation="MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNT FT FFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVLVG FT EPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQKGLP FT VRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI FT " FT CDS 45918..46580 FT /transl_table=11 FT /gene="Mb0328" FT /locus_tag="Mb0328" FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN" FT /note="Mb0328, -, len: 220 aa. Equivalent to Rv0320, len: FT 220 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 220 aa overlap). Possible conserved FT exported protein, similar to some hypothetical proteins and FT to the middle part of a peptidase: FT NP_066789.1|10657900|AAG21739.1|AF116907 putative peptidase FT from Rhodococcus equi (546 aa). Also similar to FT Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256 FT aa), FASTA scores: opt: 497, E(): 1.2e-26, (41.8% identity FT in 225 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U298" FT /protein_id="CAD93192.1" FT /translation="MGRHELARDRRKSSAVLAAVLAPAAVFFATGGDVSTLAARADANP FT VLGDDAPCCVQIVPVAPLAFSSQISGGEIGTGLAASQFASASRWRIVSRYLPVGVAPEQ FT GLQVKTVLTARSISAAFPEIREIGGVRPDALRWHPNGLALDVMVPNPGTAEGIALGNEI FT VAFVLKNATRFGMQDVIWRGAYYTPNGARTTGAGHYDHIHITTVGGGYPTGEELYIR" FT CDS 46612..47184 FT /transl_table=11 FT /gene="dcd" FT /locus_tag="Mb0329" FT /product="PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD FT (DCTP DEAMINASE)" FT /EC_number="3.5.4.13" FT /note="Mb0329, dcd, len: 190 aa. Equivalent to Rv0321, len: FT 190 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 190 aa overlap). Probable dcd FT (alterrnate gene names: dus or paxA), deoxycytidine FT triphosphate deaminase (EC 3.5.4.13), equivalent to FT CAC32024.1|AL583925 probable deoxycytidine triphosphate FT deaminase from Mycobacterium leprae (190 aa). Also highly FT similar to others e.g. FT Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46 DEOXYCYTIDINE FT TRIPHOSPHATE DEAMINASE from Streptomyces coelicolor (191 FT aa); DCD_ECOLI|P28248|DUS|PAXA|B2065 DEOXYCYTIDINE FT TRIPHOSPHATE DEAMINASE from Escherichia coli strain K12 FT (193 aa), FASTA scores: opt: 408, E(): 2.7e-21, (43.1% FT identity in 188 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE DCTP FT DEAMINASE FAMILY." FT /db_xref="GOA:Q7U297" FT /db_xref="InterPro:IPR008180" FT /db_xref="UniProtKB/Swiss-Prot:Q7U297" FT /protein_id="CAD93193.1" FT /translation="MLLSDRDLRAEISSGRLGIDPFDDTLVQPSSIDVRLDCLFRVFNN FT TRYTHIDPAKQQDELTSLVQPVDGEPFVLHPGEFVLGSTLELFTLPDNLAGRLEGKSSL FT GRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCMLRLTSPSEHPYG FT SSRAGSKYQGQRGPTPSRSCQNFIRST" FT CDS 47290..48621 FT /transl_table=11 FT /gene="udgA" FT /locus_tag="Mb0330" FT /product="PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA FT (UDP-GLC DEHYDROGENASE) (UDP-GLCDH) (UDPGDH)" FT /EC_number="1.1.1.22" FT /note="Mb0330, udgA, len: 443 aa. Equivalent to Rv0322, FT len: 443 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 443 aa overlap). Probable udg FT (alternate gene name: rkpK), UDP-glucose 6-dehydrogenase FT (EC 1.1.1.22), highly similar to others e.g. FT CAC44517.1|AL596138 putative UDP-glucose 6-dehydrogenase FT from Streptomyces coelicolor (447 aa); Q56812 UDP-GLUCOSE FT DEHYDROGENASE from Xanthomonas campestris (445 aa), FASTA FT scores: opt: 713, E(): 0, (41.9% identity in 351 aa FT overlap); etc. Also similar to several GDP-mannose FT 6-dehydrogenase. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). BELONGS TO THE UDP-GLUCOSE/GDP-MANNOSE FT DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q7U296" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U296" FT /protein_id="CAD93194.1" FT /translation="MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIP FT FYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHAVI FT DALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAVHDT FT LNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKIS FT FINAISEVCEAAGADVSQLADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGEL FT GADQALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPA FT LNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFID FT LEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH" FT CDS complement(48610..49281) FT /transl_table=11 FT /gene="Mb0331c" FT /locus_tag="Mb0331c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0331c, -, len: 223 aa. Equivalent to Rv0323c, len: FT 223 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 223 aa overlap). Conserved hypothetical FT protein, similar to others e.g. YPJG_BACSU|P42981 FT hypothetical 24.8 kd protein from Bacillus subtilis (224 FT aa), FASTA scores: opt: 182, E(): 1.3e-05, (27.5% identity FT in 211 aa overlap). Also some similarity to MLU15183_8 from FT Mycobacterium tuberculosis FASTA score: (32.0% identity in FT 147 aa overlap)." FT /db_xref="InterPro:IPR003737" FT /db_xref="UniProtKB/TrEMBL:Q7U295" FT /protein_id="CAD93195.1" FT /translation="MNSCNRLPCAHEVLAVFAHPDDESFGLGAVLGDFTAQGTRLRGLC FT FTHGEASTLGRTDRNLGEVRREELAAAAQVLGVDHVQLLAYPDNGLAQIPLNELTQRVV FT DALAGADLLLVFDDNGVTGHPDHRRATEAALAAASTPGIPVLAWALPQPIADRLNAEFS FT ASFGGRGHGHLDIMIEVDRSRQLAAIGCHFTQSADNPVLWRRLELLGDREYLRWLRRSV FT P" FT CDS 49382..50062 FT /transl_table=11 FT /gene="Mb0332" FT /locus_tag="Mb0332" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY ARSR-FAMILY)" FT /note="Mb0332, -, len: 226 aa. Equivalent to Rv0324, len: FT 226 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 226 aa overlap). Possible FT transcriptional regulator, arsR family, with its N-terminus FT similar to the N-terminus of other DNA-binding proteins FT e.g. P30346|MERR_STRLI probable mercury resistance operon FT from Streptomyces lividans (125 aa), FASTA scores: opt: FT 154, E(): 0.002, (32.2% identity in 90 aa overlap)), and FT its C-terminal part similar to hypothetical bacterial FT proteins e.g. P54510|YQHL_BACSU hypothetical 14.6 kd FT protein from Bacillus subtilis (126 aa), FASTA scores: opt: FT 159, E(): 0.00097, (35.5% identity in 76 aa overlap)). Most FT similar to AJ005575|SPE005575_2 ORF1 required for FT antibiotic production from Streptomyces peucetius (226 aa), FT FASTA scores: opt: 816, E(): 0, (60.7% identity in 211 aa FT overlap). Also similar in C-terminus to MTCY164.26 FT molybdopterin biosynthesis moeb protein from Mycobacterium FT tuberculosis FASTA score: (36.8% identity in 114 aa FT overlap)." FT /db_xref="GOA:Q7U294" FT /db_xref="InterPro:IPR001845" FT /db_xref="PDB:3GW2" FT /db_xref="UniProtKB/TrEMBL:Q7U294" FT /protein_id="CAD93196.1" FT /translation="MAGQSDRKAALLDQVARVGKALANGRRLQILDLLAQGERAVEAIA FT TATGMNLTTASANLQALKSGGLVEARREGTRQYYRIAGEDVARLFALVQVVADEHLADV FT AVAAADVLGSPEDAITRAELLRRREAGEVTLVDVRPHEEYQAGHIPGAINIPIAELADR FT LAELAGDRDIVAYCRGAYCVMAPDAVRIARDAGREVKRLDDGMLEWRLAGLPVDEGAPV FT GHGD" FT CDS 50069..50758 FT /transl_table=11 FT /gene="Mb0333" FT /locus_tag="Mb0333" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0333, -, len: 229 aa. Equivalent to Rv0325 and FT Rv0326, len: 74 aa and 151 aa, from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 74 aa FT overlap and 100.0% identity in 151 aa overlap). FT Hypothetical unknown protein. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 FT genes. In Mycobacterium bovis, the absence of a stop codon FT between Rv0325 and Rv0326 due to a single base transition FT (t-c) leads to single product." FT /db_xref="GOA:Q7U293" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q7U293" FT /protein_id="CAD93197.1" FT /translation="MGPKGSLRLVKRQPELLVAQHEHWQDTYRAHPVLYGTRPSEPGVY FT AAEVFNADGVQRVLELAAGHGRDTLYFAGQGFTVVATDFSDVAVAQLRRSAQARGVSAR FT VQPIVHDLRQPLPVKTGSIDGAFAHMALCMALSTSEIHAVVAEVGRVLRPGGKFIYTVR FT HTGDAHYGAGQAHGDDIFECAGFAVHFFRRELVARLATGWVLEEVHDFEEGELPRRLWR FT VTVTKPA" FT CDS complement(50726..52075) FT /transl_table=11 FT /gene="cyp135A1" FT /locus_tag="Mb0334c" FT /product="POSSIBLE CYTOCHROME P450 135A1 CYP135A1" FT /EC_number="1.14.-.-" FT /note="Mb0334c, cyp135A1, len: 449 aa. Equivalent to FT Rv0327c, len: 449 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.8% identity in 449 aa overlap). Possible FT cyp135A1, cytochrome P450 (EC 1.14.-.-), similar to FT cytochrome P-450 monoxygenases and other cytochrome P-450 FT related enzymes e.g. FQ12609 PUTATIVE P450 MONOOXYGENASE FT (EC 1.14.14.1) (506 aa), FASTA scores: opt: 276, E() : FT 1.7e-11, (27.9% identity in 433 aa overlap). Also similar FT to other Mycobacterium tuberculosis proteins e.g. FT MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa); FT MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in FT 434 aa overlap). Contains cytochrome P450 cysteine FT heme-iron ligand signature (PS00086). BELONGS TO THE FT CYTOCHROME P450 FAMILY. Alternative start possible at 33706 FT but no RBS." FT /db_xref="GOA:Q7U292" FT /db_xref="HSSP:1P0W" FT /db_xref="InterPro:IPR017973" FT /db_xref="UniProtKB/TrEMBL:Q7U292" FT /protein_id="CAD93198.1" FT /translation="MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFSL FT RVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEYARMR FT SLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTD FT PKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIASRRI FT DSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLWELAHA FT PEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPAGTVVNT FT SILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTEGAVILQE FT IFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP" FT CDS 52141..52743 FT /transl_table=11 FT /gene="Mb0335" FT /locus_tag="Mb0335" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR/ACRR-FAMILY)" FT /note="Mb0335, -, len: 200 aa. Equivalent to Rv0328, len: FT 200 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 200 aa overlap). Possible transcription FT regulator, tetR/acrR family, similar in part to various FT hypothetical transcriptional regulators e.g. FT T36696|4726006|CAB41735.1|AL049731 probable regulatory FT protein from Streptomyces coelicolor (197 aa). Also some FT similarity with YX44_MYCTU|Q10829 hypothetical FT transcriptional regulator from Mycobacterium tuberculosis FT (195 aa), FASTA scores: opt: 154, E(): 0.00061, (26.7% FT identity in 202 aa overlap). Contains probable helix-turn FT helix motif from aa 27-48 (Score 1408, +3.98 SD). SEEMS TO FT BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL FT REGULATORS." FT /db_xref="GOA:Q7U291" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U291" FT /protein_id="CAD93199.1" FT /translation="MQQQRTNRDKLLDGALACLRERGYGNTSSRDIARAAGVNIASINY FT HFGSKDALLDDALGRCFSTWNQRVQEAFDHSRAAGPAGQILAVLEATVDSFEQIRPAVY FT ACVESYAPALRSEALRERLAAGYADVRQHSVDLAGAALAGTDIAPPENLSTIVSVLMAV FT IDGLMIQWIADPSATPRSTEVIRALASIGAVVTSQLR" FT CDS complement(52724..53350) FT /transl_table=11 FT /gene="Mb0336c" FT /locus_tag="Mb0336c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0336c, -, len: 208 aa. Equivalent to Rv0329c, len: FT 208 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 208 aa overlap). Conserved hypothetical FT protein, showing some similarity with others hypothetical FT proteins and methyltransferases e.g. MitM|AF127374_14 FT methyltransferase from Streptomyces lavendulae (283 aa), FT FASTA scores: opt: 242, E(): 1.8e-08, (37.2% identity in FT 145 aa overlap); Q48938 from Methanosarcina barkeri (262 FT aa), FASTA scores: opt: 194, E(): 3.6e-06, (31.1% identity FT in 119 aa overlap)." FT /db_xref="GOA:Q7U290" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q7U290" FT /protein_id="CAD93200.1" FT /translation="MRLTHPARRYLSSQAARPTGAFGRLLGRIWRAETADVNRIAVELL FT APGPGERVCEIGFGPGRTLGLLAAAGAQVSGVEVSTTMIAIAAHHNAKAIAAGLISLYH FT GDGVTLPVADHSLDKVLGVHNFYFSPDPRASLCDIARALRPGGRLVLTSISDDQPLAAR FT FDPAIYRVPPTLDTAAWLGAAGFIDVGIKRSADHPATVWFTATAT" FT CDS complement(53377..54117) FT /transl_table=11 FT /gene="Mb0337c" FT /locus_tag="Mb0337c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0337c, -, len: 246 aa. Equivalent to Rv0330c, len: FT 246 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 246 aa overlap). Hypothetical unknown FT protein." FT /db_xref="GOA:Q7U289" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U289" FT /protein_id="CAD93201.1" FT /translation="MARSIPADRFSAIVAASARVFIAHGYQRTQVQDVADALALAKGTL FT YGYAQGKAALFAAAVRYGDAQEALPLASELPVAAPVAGEIAAVVSARLAGEVTDMRLTH FT ALRATLPPGATTGDARAELAGIVTDLYSRLARHRIALKLVDRCAPELPDLAEVWFGTGR FT NAQVDAVQAYLVHRERAGLLILPGPAPMVARTIVELCALWAVHLHFDPSPEPWSIVQPG FT VIDDDAIAATLAEFVVRATTASSD" FT CDS 54231..55397 FT /transl_table=11 FT /gene="Mb0338" FT /locus_tag="Mb0338" FT /product="POSSIBLE DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0338, -, len: 388 aa. Equivalent to Rv0331, len: FT 388 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 388 aa overlap). Possible FT dehydrogenase/reductase (EC 1.-.-.-), similar to various FT dehydrogenases/reductases e.g. FT NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein FT reductase from Mesorhizobium loti (377 aa); NP_147681.1 FT predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum FT pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase FT (431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6% FT identity in 348 aa overlap). TBparse score is 0.906." FT /db_xref="GOA:Q7U288" FT /db_xref="InterPro:IPR015904" FT /db_xref="UniProtKB/TrEMBL:Q7U288" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93202.1" FT /translation="MSKTVLILGAGVGGLTTADTLRQLLPPEDRIILVDRSFDGTLGLS FT LLWVLRGWRRPDDVRVRPTAASLPGVEMVTATVAHIDIAAQVVHTDNSVIGYDALVIAL FT GAALNTDAVPGLSDALDADVAGQFYTLDGAAELRAKVEALEHGRIAVAIAGVPFKCPAA FT PFEAAFLIAAQLGDRYATGTVQIDTFTPDPLPMPVAGPEVGEALVSMLKDHGVGFHPRK FT ALARVDEAARTMHFGDGTSEPFDLLAVVPPHVPSAAARSAGLSESGWIPVDPRTLSTSA FT DNVWAIGDATVLTLPNGKPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTGTGACYV FT ETGDHQAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT" FT CDS 55472..56257 FT /transl_table=11 FT /gene="Mb0339" FT /locus_tag="Mb0339" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0339, -, len: 261 aa. Equivalent to Rv0332, len: FT 261 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 261 aa overlap). Conserved hypothetical FT protein, similar to several conserved hypothetical proteins FT from Streptomyces coelicolor e.g. FT SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein FT (266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7% FT identity in 251 aa overlap)." FT /db_xref="InterPro:IPR010872" FT /db_xref="UniProtKB/TrEMBL:Q7U287" FT /protein_id="CAD93203.1" FT /translation="MRKPASSLAKVDYSSAYLEQTHAFGELIRNVDQSTPVPTCPGWSL FT GQLFRHVGRGDRWAAQIVRDRLDHFLDPRSVEGGKPPPDPDDAISWLYGGARLLVDAVE FT QTGVETPVWTFLGPRPAGWWVRRRLHEVAVHRADVAITVGGEFTLEPNVAADGISEFLE FT RIAVQAGSGGTPLPLEDDDTLHLHATDPGLLEAGGWTVRRDERGVTWSHRHGKGAVALR FT GGATELLLAMVRRLSVADTGIELLGDAGVWQKWLDRTPL" FT CDS 56284..56658 FT /transl_table=11 FT /gene="Mb0340" FT /locus_tag="Mb0340" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0340, -, len: 124 aa. Equivalent to Rv0333, len: FT 124 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 124 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U286" FT /protein_id="CAD93204.1" FT /translation="MTTSEIATVLAWHDALNAADIETLVALSTDDIDIGDAHGAVQGHD FT ALRGWASSLTTTAELGRMYVHHGVVVVEQKITSGEDPGIARTGAAAFRVVQDHVASVFR FT HEDLASALAATELTEDDLVD" FT CDS 56688..57554 FT /transl_table=11 FT /gene="rmlA" FT /locus_tag="Mb0341" FT /product="PROBABLE GLUCOSE-1-PHOSPHATE FT THYMIDYLYLTRANSFERASE RMLA (DTDP-GLUCOSE SYNTHASE) FT (DTDP-GLUCOSE PYROPHOSPHORYLASE)" FT /EC_number="2.7.7.24" FT /note="Mb0341, rmlA, len: 288 aa. Equivalent to Rv0334, FT len: 288 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 288 aa overlap). Probable rmlA FT (alternate gene name: rfbA), glucose-1-phosphate FT thymidylyl-transferase (EC 2.7.7.24), equivalent to FT CAC32020.1|AL583925 glucose-1-phosphate thymidyltransferase FT from Mycobacterium leprae (288 aa). Also highly similar to FT others e.g. AAG29804.1|AF235050 glucose-1-phosphate FT thymidylyltransferase from Streptomyces rishiriensis (296 FT aa); RBA1_ECOLI|P37744 glucose-1-phosphate FT thymidylyltransferase from Escherichia coli strain K12 (293 FT aa), FASTA scores: opt: 1199, E(): 0, (62.0% identity in FT 284 aa overlap). BELONGS TO THE GLUCOSE-1-PHOSPHATE FT THYMIDYLYLTRANSFERASE FAMILY." FT /db_xref="GOA:Q7U285" FT /db_xref="HSSP:1FXO" FT /db_xref="InterPro:IPR005835" FT /db_xref="UniProtKB/TrEMBL:Q7U285" FT /protein_id="CAD93205.1" FT /translation="MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAG FT IRDIQLITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGADSVAL FT VLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAEGMALSLEEKPVTP FT KSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVNQVYLNQGRLAVEVLARGTAWLD FT TGTFDSLLDAADFVRTLERRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSGYGNYL FT LELLERN" FT CDS complement(57565..58080) FT /transl_table=11 FT /gene="PE6" FT /locus_tag="Mb0342c" FT /product="PE FAMILY PROTEIN" FT /note="Mb0342c, PE6, len: 171 aa. Equivalent to Rv0335c, FT len: 171 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 171 aa overlap). Member of the FT Mycobacterium tuberculosis PE family (see first citation FT below); contains short region of similarity to part of the FT unique N-terminus of the Mycobacterium tuberculosis PGRS FT family of Glycine-rich proteins e.g. Y03A_MYCTU|Q10637 FT hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA FT scores: opt: 219, E(): 1.1e-08, (51.5% identity in 66 aa FT overlap)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U284" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93206.1" FT /translation="MRSMGFLHRACRAPSSLPAPLMARPGRSVLARPAATPPGPLCATT FT RPRPPQGNQPPASRISNFPPKRHKTRVLAAAEDEVSAAVAALISAHGRRHHSLNNQAAA FT FHGQFAQNLNVGAGSCASAETTADAPTQALLGPADRQRRQRRAVRQWLVRWAAHPGRAT FT RGFHNHRQ" FT CDS 58222..59733 FT /transl_table=11 FT /gene="Mb0343" FT /locus_tag="Mb0343" FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT /note="Mb0343, -, len: 503 aa. Equivalent to Rv0336, len: FT 503 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 503 aa overlap). Part of Mycobacterium FT tuberculosis 13E12 repeat family; almost identical to FT Rv0515|MTCY20G10.05 hypothetical protein from M. FT tuberculosis FASTA scores: (99.8% identity in 503 aa FT overlap), possibly due to a recent gene duplication. Also FT similar to other Mycobacterium tuberculosis hypothetical FT proteins e.g. Rv1148c, Rv1945, etc." FT /db_xref="GOA:Q7TTD9" FT /db_xref="InterPro:IPR003870" FT /db_xref="UniProtKB/TrEMBL:Q7TTD9" FT /protein_id="CAD93207.1" FT /translation="MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAA FT QLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERL FT PKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQV FT DKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTV FT CEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATING FT TGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDL FT TCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTL FT ILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQD FT RAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDHNDDPPPF" FT CDS complement(59903..61192) FT /transl_table=11 FT /gene="aspC" FT /locus_tag="Mb0344c" FT /product="PROBABLE ASPARTATE AMINOTRANSFERASE ASPC FT (TRANSAMINASE A) (ASPAT)" FT /EC_number="2.6.1.1" FT /note="Mb0344c, aspC, len: 429 aa. Equivalent to Rv0337c, FT len: 429 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 429 aa overlap). Probable aspC, FT aspartate aminotransferase (transaminase A) (EC 2.6.1.1), FT equivalent to CAC32019.1|AL583925 probable aspartate FT aminotransferase from Mycobacterium leprae (437 aa). Also FT highly similar to many e.g. Q48143|U32823 aspartate FT aminotransferase (404 aa), FASTA scores: opt: 1646, E(): 0, FT (57.2% identity in 404 aa overlap). Also some similarity to FT Rv3565|MTCY06G11.12 from Mycobacterium tuberculosis FASTA FT score: (27.2% identity in 383 aa overlap). BELONGS TO FT CLASS-I OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. FT COFACTOR: PYRIDOXAL PHOSPHATE." FT /db_xref="GOA:P63499" FT /db_xref="HSSP:1BKG" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P63499" FT /protein_id="CAD93208.1" FT /translation="MDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGPV FT HQHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSARRA FT VVTRYELVPGFPRFDVDDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTASTSL FT AGGTPVHYLCDETQGWQPDIADLESKITERTKALVVINPNNPTGAVYSCEILTQMVDLA FT RKHQLLLLADEIYDKILYDDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGWLAITG FT PKEHASSFIEGIGLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQRDIAWT FT KLNEIPGVSCVKPAGALYAFPRLDPEVYDIDDDEQLVLDLLLSEKILVTQGTGFNWPAP FT DHLRLVTLPWSRDLAAAIERLGNFLVSYRQ" FT CDS complement(61223..63871) FT /transl_table=11 FT /gene="Mb0345c" FT /locus_tag="Mb0345c" FT /product="PUTATIVE IRON-SULFUR-BINDING REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0345c, -, len: 882 aa. Equivalent to Rv0338c, len: FT 882 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 882 aa overlap). Probable FT iron-sulphur-binding reductase (EC 1.-.-.-), possibly FT membrane-bound, equivalent to CAC32018.1|AL583925 probable FT iron-sulphur-binding reductase from Mycobacterium leprae FT (880 aa). Also highly similar to others e.g. FT T36608|5019323|CAB44376.1|AL078610 probable FT iron-sulfur-binding reductase from Streptomyces coelicolor FT (760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity FT in 772 aa overlap); BAB07521.1|AP001520 FT iron-sulphur-binding reductase from Bacillus halodurans FT (700 aa). Contains PS00070 Aldehyde dehydrogenases cysteine FT active site and two of PS00198 4Fe-4S ferredoxins, FT iron-sulfur binding region signature. First of several FT possible start sites chosen." FT /db_xref="GOA:Q7U283" FT /db_xref="InterPro:IPR017900" FT /db_xref="UniProtKB/TrEMBL:Q7U283" FT /protein_id="CAD93209.1" FT /translation="MTTQTLIRLILGMSMTAVVGVFALRRVWWLYKLVMSGQPASGRTD FT NLGTRIWTQISEVLGQRRLLKWSIPGLAHFFTMWGFFILLTVYIEAYGLLFEERFHIPV FT IGRWDALGFLQDFFATAVFLGITTFAIIRILRNPREIGRSSRFYGSHNGGAWLVLLMIF FT NVIWTYVLVRGSAVNNGTLPYGNGAFLSQLFGAILRPLGQPANEIIETTALLLHIGVML FT AFLILVLHSKHLHIFLAPINVTFKRLPDGLGPLLPLEADGKPIDFENPSEDAVFGRGKI FT EDFTWKGMLDFATCTECGRCQSQCPAWNTGKPLSPKLVIMDLRDHWMAKAPYILGQKDA FT SAGGEAGHQEHHHVPESGFGRVPGHGPEQATRPLVGTEEQGGVIDPDVLWSCVTCGACV FT EQCPVDIEHVDHIVDMRRYQVMMESEFPSELSVLFKNLETKGNPWGQNASDRTNWIDEV FT DFDVPVYGQDVDSFDGYEYLFWVGCAGAYDDKAKKTTKAVAELLAVAGVKYLVLGAGET FT CNGDSARRSGNEFLFQQLAQQAVETLDGLFEGVETVDRKIVVTCPHCFNTIGKEYRQLG FT ANYTVLHHTQLLNRLVRDKRLVPVTPVSQDITYHDPCYLGRHNKVYEAPRELIGAAGAS FT LTEMPRHADRSFCCGAGGARMWMEEHIGKRINHERVDEALATDATAIATACPFCRVMVT FT DGVNDRQEEAGRSGVEVLDVAQVLLGSLDHDKAQLPAKGTAAKQAQERAPKAAPKAAAP FT VTPVEAPAEAPQAPAPAAPAAPVKGLGMAAGAKRPGAKKAAPTPAAPAAPAAPVKGLGI FT AAGAKRPGAKKTPPPAPGLAEPAAQPQPEAKPQPEPAAPPKPQTDGDPAAPAAPVKGLG FT IARGARPPGKR" FT CDS complement(63980..66478) FT /transl_table=11 FT /gene="Mb0346c" FT /locus_tag="Mb0346c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0346c, -, len: 832 aa. Equivalent to Rv0339c, len: FT 832 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 832 aa overlap). Possible FT transcriptional regulator, showing very weak similarity FT with parts of others. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop ); and probable helix-turn helix motif from FT aa 778-799 (Score 1041, +2.73 SD)." FT /db_xref="GOA:Q7U282" FT /db_xref="HSSP:1FSE" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:Q7U282" FT /protein_id="CAD93210.1" FT /translation="MQHRGCKNRGQAYDASVTDSLTEVPPAARRALLELANAPTVPVKV FT LITGGIGTGKTTVLAAARDTLRRSGLTVLACPPPDGEPPETALVIDDAQLLTDTELLRL FT TERVADSRLTVVAAAEAREHHRALRALTMALERDRPRISLGPLPVAEHLRDCTAGLPFL FT IHAVSARAQAPAQAAKVALIERLRRLDEPTLDTLLMMSLTHELGVSDVAAALGISVTDA FT RGLVDRAHASGLIESSHTAAFLQSVHDAIAQIVGNAHHHEVETSLLRSQLDISPVSAEL FT ALRLAEHGLRDERLADILTRYAADTRDASVRCARLYRAAVHAGAKGLTVRLADALARTG FT DCTAAATLADDLLSSPDATERAAAVRVAASVAVHDGNTGHAAELFGWLGPHPDTMVSSA FT ATIVFAANGDLATARATLRLKDAGPPTMAARCARNLAEGLLLTMDQPYPVAMAKLGQAI FT ATEQSLSQVIPDSPAALVTLAAIHAGDPVRARSVIGRAVRAGADPLFQRRHLLLSGWIK FT MQEGQLPSASADVAAASAGTHLHRRDALWAAALQTAISRRTGDIGALQQHWYAAMEALA FT EYSLDLFALLPLGELWVAAARMRQVDQLQHTLDQALTLLDSLGNPALWSNSLHWAGVHA FT GILANSPESVAPHGQALGAMVAHSTLAQALSDAGRTWLRVLAENVDADEVTAAARSLSH FT VGLTSDATRLAGQAALQTSDARVSGAMLQLARDLKLGNDFGEPPSGAGDTEPASGTPPA FT PRQPPAGSPLSDREREVAELLLLGMPYRDIGARLFISAKTVEHHVARIRQRLGAGSRSE FT MLSMLRAMLAPESLTADERR" FT CDS 66664..67203 FT /transl_table=11 FT /gene="Mb0347" FT /locus_tag="Mb0347" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0347, -, len: 179 aa. Equivalent to Rv0340, len: FT 179 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 179 aa overlap). Conserved hypothetical FT protein; MEME-MAST analysis shows similarity to product of FT downstream gene, Rv0341|iniB." FT /db_xref="UniProtKB/TrEMBL:Q7U281" FT /protein_id="CAD93211.1" FT /translation="MANSLLDFVISLVRDPEAAARYAANPERSIAEAHLTDVTRADVNS FT LIPVVSDSLSMSEPIGAAGGAHAGDRGNVWASGAATAALDAFAPHADAGVVQQHGAVGS FT VLNQPTPPGPGVTPTDPRPFRAGPHETSALLTSAEIPDTTSEDGGLPTDHPAVWNHPVV FT DPHTVEPDHHGYDIHG" FT CDS 67392..68831 FT /transl_table=11 FT /gene="iniB" FT /locus_tag="Mb0348" FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIB" FT /note="Mb0348, iniB, len: 479 aa. Equivalent to Rv0341, FT len: 479 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 479 aa overlap). iniB, FT isoniazid-inducible gene, (see citations below). Protein FT very Gly-, Ala-rich, similar to cell wall proteins e.g. FT P27483|GRP_ARATH GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN FT from A.thaliana (338 aa), FASTA scores: opt: 532, E(): FT 5.2e-13, (39.3% identity in 321 aa overlap). MEME-MAST FT analysis shows similarity to product of upstream gene, FT Rv0340." FT /db_xref="InterPro:IPR002202" FT /db_xref="UniProtKB/TrEMBL:Q7U280" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93212.1" FT /translation="MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISSV FT AANVVPGLNLGAGDPMSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAGLA FT SGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGTGLG FT AQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRLGGNGQIGVAGQGAVGAGVGA FT GVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGA FT AMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAAAGVVGG FT VGGATAAGVGGAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGGTGGYGGM FT NPPVTDAPAPQVPARAQPMTTAAEHTPAVTQPQHTPVEPPVHDKPPSHSVFDVGHEPPV FT THTPPAPIELPSYGLFGLPGF" FT CDS 68868..70790 FT /transl_table=11 FT /gene="iniA" FT /locus_tag="Mb0349" FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIA" FT /note="Mb0349, iniA, len: 640 aa. Equivalent to Rv0342, FT len: 640 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 640 aa overlap). iniA, FT isoniazid-inducible gene, (see citations below). Shows FT slight similarity to some hypothetical bacterial proteins FT e.g. P40983|YOR6_THER hypothetical protein (402 aa), FASTA FT scores: opt: 242, E(): 1.4e-07, (22.3% identity in 349 aa FT overlap). Also some similarity to downstream ORF FT Rv0343|iniC. Possible transmembrane stretch around residue FT 490. Alternative translational start at 410824. Contains a FT phosphopantetheine attachment site motif suggestive of an FT acyl carrier protein. Note that the iniA gene is also FT induced by the antibiotic ethambutol, an agent that FT inhibits cell wall biosynthesis by a mechanism that is FT distinct from isoniazid." FT /db_xref="UniProtKB/TrEMBL:Q7U279" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93213.1" FT /translation="MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIA FT IAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLSSLLNLPAARVGDDEAT FT VVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAP FT SPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAH FT QICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELN FT EESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRL FT ASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCD FT PTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHV FT MGTDFGRLKALGRMESKPLRRGQKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAG FT LILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYRE FT IAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRA FT SLGRA" FT CDS 70787..72268 FT /transl_table=11 FT /gene="iniC" FT /locus_tag="Mb0350" FT /product="ISONIAZID INDUCTIBLE GENE PROTEIN INIC" FT /note="Mb0350, iniC, len: 493 aa. Equivalent to Rv0343, FT len: 493 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 493 aa overlap). iniC, FT isoniazid-inducible gene, (see citations below). Shows FT slight similarity to P40983|YOR6_THER8 hypothetical protein FT (402 aa), FASTA scores: opt: 196, E(): 2.6e-05, (25.9% FT identity in 228 aa overlap). Also some similarity to FT upstream ORF Rv0342|iniA. Contains (PS00017) FT ATP/GTP-binding site motif A (P-loop). Note that the iniA FT gene is also induced by the antibiotic ethambutol, an agent FT that inhibits cell wall biosynthesis by a mechanism that is FT distinct from isoniazid." FT /db_xref="UniProtKB/TrEMBL:Q7U278" FT /protein_id="CAD93214.1" FT /translation="MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEPL FT RIALAGTLKAGKSTLVNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRANV FT PITRRGGLSFDLRRINPAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLRLLV FT PADGVPRVDAVVFLLRTLNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAGRIDA FT MLSANDVAKRFTRELNQMGICQAVVPVSGLLALTARTLRQTEFIALRKLAGAERTELNR FT ALLSVDRFVRRDSPLPVDAGIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAAELLERS FT GLVALRNVIDQQFAQRSDMLKAHTALVSLRRFVQTHPVPATPYVIADIDPLLADTHAFE FT ELRMLSLLPSRATTLNDDEIASLRRIIGGSGTSAAARLGLDPANSREAPRAALAAAQHW FT RRRAAHPLNDPFTTRACRAAVRSAEAMVAEFSARR" FT CDS complement(72411..72971) FT /transl_table=11 FT /gene="lpqJ" FT /locus_tag="Mb0351c" FT /product="PROBABLE LIPOPROTEIN LPQJ" FT /note="Mb0351c, lpqJ, len: 186 aa. Equivalent to Rv0344c, FT len: 186 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 186 aa overlap). Probable lipoprotein, FT without homology. Has an appropriately positioned FT prokaryotic lipoprotein signature (PS00013)." FT /db_xref="UniProtKB/TrEMBL:Q7U277" FT /protein_id="CAD93215.1" FT /translation="MRLSLIARGMAALLAATALVAGCNTTIDGRPVASPGSGPTEPTFP FT TPRPTTAPPGTTAPTLPTTPVSPTAPAGAIPLPPDSNGYVFIETKSGMTRCQINRDSVG FT CEAPFTNSPLRDGEHANGIHITAGGSVQWVLGNLGAIPTVSIDYRTYEAQGWTIDATTD FT GTRFTNNRTGHGMFVSIEKVDTF" FT CDS 73217..73489 FT /transl_table=11 FT /gene="Mb0353" FT /locus_tag="Mb0353" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0353, -, len: 90 aa. Equivalent to 3' end of FT Rv0345, len: 136 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 90 aa overlap). Conserved FT hypothetical protein, similar to other hypothetical FT proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from FT Streptomyces coelicolor (207 aa), FASTA scores: opt: 188, FT E(): 1.5e-05, (41.0% identity in 117 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT frameshift due to a single base deletion (a-*) leads to a FT shorter product with a different NH2 part compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv." FT /db_xref="UniProtKB/TrEMBL:Q7U276" FT /protein_id="CAD93216.1" FT /translation="MVLGAVEVSAPAGVTAITAPDWQQGLSASVRAGLAQADREHADYA FT VLHVIDTPDVNAKVVARVLGRALVSRSGLAGRGRIPAHSARRRGC" FT CDS complement(73531..74994) FT /transl_table=11 FT /gene="ansP2" FT /locus_tag="Mb0354c" FT /standard_name="aroP2" FT /product="POSSIBLE L-ASPARAGINE PERMEASE ANSP2 FT (L-ASPARAGINE TRANSPORT PROTEIN)" FT /note="Mb0354c, ansP2, len: 487 aa. Equivalent to Rv0346c, FT len: 487 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 487 aa overlap). Possible ansP2, FT L-asparagine permease, integral membrane protein belonging FT to family containing many amino acid permeases, highly FT similar to G467030|B2126_F2_85|NP_301937.1|NC_002677 FT probable L-asparagine permease from Mycobacterium leprae FT (498 aa); and NP_301938.1|NC_002677 probable L-asparagine FT permease from Mycobacterium leprae (505 aa). Also highly FT similar to others e.g. P77610|ANSP_ECOLI L-ASPARAGINE FT PERMEASE from Escherichia coli strain K-12 (499 aa). Also FT highly similar to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 FT PROBABLE L-ASPARAGINE PERMEASE from Mycobacterium FT tuberculosis (489 aa), FASTA score: (72.1% identity in 473 FT aa overlap). And shows some similarity to MTCY3G12.14 from FT Mycobacterium tuberculosis. BELONGS TO THE AMINO ACID FT PERMEASE FAMILY (APC FAMILY). Note that previously known as FT aroP2." FT /db_xref="GOA:P0A4W1" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/Swiss-Prot:P0A4W1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93217.1" FT /translation="MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGAG FT GRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGSFVSYAREFYGEKVAFVAGW FT MYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLALIALLVVLSMNLISVRLFGELEF FT WASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTGLLPIVLVTSGVV FT FAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAYKEHVS FT PFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRFTAPMSK FT TGVPYGGILLTAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMA FT NAGQLQRPKFRMPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWY FT LVRNRVTAVAHHAIDHTKSVAVVHSADPI" FT CDS 75333..76319 FT /transl_table=11 FT /gene="Mb0355" FT /locus_tag="Mb0355" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0355, -, len: 328 aa. Equivalent to Rv0347, len: FT 328 aa (alternative start possible), from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 328 aa FT overlap). Probable conserved membrane protein, similar to FT Rv0831c|AL022004|MTV043_23 from Mycobacterium tuberculosis FT (271 aa), FASTA scores: E(): 9.6e-21, (33.1% identity in FT 266 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U275" FT /protein_id="CAD93218.1" FT /translation="MPGARELTLRVERGALFRRRWAASAASSARAAIRRDPRRCALGTR FT PRWVSFLVIVLVIMNVVTAHPKYPNDPLALVLIELRHPRTEPPVPSAISILKEELARWT FT PILEQEEVRQVNLETGEHTAHSQKKLVARDRRTAITFRPDAMTLEVTDYPGWEEFRSIV FT HAMVTARQDVAPVDGCIRIGLRYINEIRASLAEPSGWAYWVAESLLGPGTQLADLKLTT FT TAQRHVIQCEGPEPGDSLTLRYAGARGAVIQSTPFLQRLKEPPAEGDFFLIDIDSAWSD FT PCKGIPALDAHLVDEVAERLHTPIGPLFESLITSELRTKVLQQPGQE" FT CDS 76322..76975 FT /transl_table=11 FT /gene="Mb0356" FT /locus_tag="Mb0356" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0356, -, len: 217 aa. Equivalent to Rv0348, len: FT 217 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 217 aa overlap). Possible FT transcriptional regulator, showing some similarity to FT O53334|RV3188|MTV014.32 CONSERVED HYPOTHETICAL PROTEIN from FT Mycobacterium tuberculosis (115 aa), FASTA score: (30.0% FT identity in 100 aa overlap). Contains probable helix-turn FT helix motif from aa 89-110 (Score 1407, +3.98 SD)." FT /db_xref="UniProtKB/TrEMBL:Q7U274" FT /protein_id="CAD93219.1" FT /translation="MTISFSSSNLRDDATSGNGDYRLDKLPETTPSTSVFDRADVTYRQ FT FTELHGQARDTRREAHVVELESKTGERARCAPMHALEQLADYGFAWRDIARVVGVSVPA FT ITKWRKGAGVTGENRLKIARLLALIDMLSDRFIGEPASWLEMPIQAGVGITRMDLLERG FT RYDLVLALASTHTGDGTVEYVLNETDKDWRETVVDNAFESYTAEDGVISIRPKR" FT CDS 76978..77637 FT /transl_table=11 FT /gene="Mb0357" FT /locus_tag="Mb0357" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0357, -, len: 219 aa. Equivalent to Rv0349, len: FT 219 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 219 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U273" FT /protein_id="CAD93220.1" FT /translation="MPELETPDDPESIYLARLEDVGEHRPTFTGDIYRLGDGRMVMILQ FT HPCALRHGVDLHPRLLVAPVRPDSLRSNWARAPFGTMPLPKLIDGQDHSADFINLELID FT SPTLPTCERIAVLSQSGVNLVMQRWVYHSTRLAVPTHTYSDSTVGPFDEADLIEEWVTD FT RVDDGADPQAAEHECASWLDERISGRTRRALLSDRQHASSIRREARSHRKSVKLAD" FT CDS 77864..79741 FT /transl_table=11 FT /gene="dnaK" FT /locus_tag="Mb0358" FT /standard_name="hsp70" FT /product="PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK FT PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70)" FT /EC_number="3.6.1.-" FT /note="Mb0358, dnaK, len: 625 aa. Equivalent to Rv0350, FT len: 625 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 625 aa overlap). Probable DnaK FT (alternate gene name: hsp70), 70 kDa heat shock protein FT (see citations below), equivalent to FT AAA25362.1|M95576|1924344A|738248 heat shock protein 70 FT from Mycobacterium leprae (621 aa); and DNAK_MYCPA|Q00488 FT (623 aa), FASTA scores: opt: 3678, E(): 0, (92.3% identity FT in 625 aa overlap). Also highly similar to others e.g. FT Q05558|DNAK_STRCO|453231|CAA54606.1|X77458 CHAPERONE FT PROTEIN DNAK from Streptomyces coelicolor (618 aa). Has FT probably an ATPase activity (EC 3.6.1.-). Note that this FT sequence differs from DNAK_MYCTU|P32723 (609 aa), due to a FT frameshift near the N-terminus. BELONGS TO THE HEAT SHOCK FT PROTEIN 70 FAMILY." FT /db_xref="GOA:P0A5C0" FT /db_xref="HSSP:1DG4" FT /db_xref="InterPro:IPR013126" FT /db_xref="UniProtKB/Swiss-Prot:P0A5C0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93221.1" FT /translation="MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARN FT GEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRDAE FT AYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKE FT QRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGI FT DLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRI FT TQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVN FT PDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSET FT FTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIV FT HVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLV FT YQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSAMEKLGQESQA FT LGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREAK" FT CDS 79738..80445 FT /transl_table=11 FT /gene="grpE" FT /locus_tag="Mb0359" FT /product="PROBABLE GRPE PROTEIN (HSP-70 COFACTOR)" FT /note="Mb0359, grpE, len: 235 aa. Equivalent to Rv0351, FT len: 235 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 235 aa overlap). Probable grpE protein FT (HSP-70 COFACTOR), equivalent to CAC32012.1|AL583925 Hsp70 FT cofactor from Mycobacterium leprae (229 aa). Also highly FT similar to others eg Q05562|GRPE_STRCO|2127521|PN0643 GRPE FT PROTEIN from Streptomyces coelicolor (225 aa). Contains FT grpE protein signature (PS01071). BELONGS TO THE GRPE FT FAMILY." FT /db_xref="GOA:Q7U272" FT /db_xref="InterPro:IPR009012" FT /db_xref="UniProtKB/Swiss-Prot:Q7U272" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93222.1" FT /translation="MTDGNQKPDGNSGEQVTVTDKRRIDPETGEVRHVPPGDMPGGTAA FT ADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLER FT ARKHGDLESGPLKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEGDGGQGSKPV FT IGTVMRQGYQLGEQVLRHALVGVVDTVVVDAAELESVDDGTAVADTAENDQADQGNSAD FT TLGEQAESEPSGS" FT CDS 80481..81668 FT /transl_table=11 FT /gene="dnaJ1" FT /locus_tag="Mb0360" FT /standard_name="dnaJ" FT /product="PROBABLE CHAPERONE PROTEIN DNAJ1" FT /note="Mb0360, dnaJ1, len: 395 aa. Equivalent to Rv0352, FT len: 395 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 395 aa overlap). Probable DnaJ1, FT chaperone protein, equivalent to AAA25363.1|M95576 DNA J FT heatshock protein from Mycobacterium leprae (389 aa). Also FT highly similar to others. Contains both DnaJ signatures FT (PS00636, and PS00637). BELONGS TO THE DNAJ FAMILY. FT COFACTOR: BINDS TWO ZINC IONS PER MONOMER. Note that FT sequence differs from DNAJ_MYCTU|P07881 due to a frameshift FT at the N-terminus. Note that previously known as dnaJ." FT /db_xref="GOA:P0A549" FT /db_xref="HSSP:1HDJ" FT /db_xref="InterPro:IPR001305" FT /db_xref="UniProtKB/Swiss-Prot:P0A549" FT /protein_id="CAD93223.1" FT /translation="MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGN FT PAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGD FT GAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAK FT GVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGS FT GSIIEHPCEECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTV FT HVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRG FT RGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR" FT CDS 81668..82048 FT /transl_table=11 FT /gene="hspR" FT /locus_tag="Mb0361" FT /product="PROBABLE HEAT SHOCK PROTEIN TRANSCRIPTIONAL FT REGULATOR HSPR (MERR FAMILY)" FT /note="Mb0361, hspR, len: 126 aa. Equivalent to Rv0353, FT len: 126 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 126 aa overlap). Probable hspR, heat FT shock regulatory protein, merR family, highly similar to FT others e.g. HspR|P40183 heat shock regulatory protein from FT Streptomyces coelicolor (151 aa), FASTA scores: E(): FT 4.9e-22, (55.7% identity in 140 aa overlap), that binds to FT three inverted repeats (IR1-IR3) in the promoter region of FT the dnaK operon. Has possible coiled coil region in FT C-terminal half. BELONGS TO THE MERR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7U271" FT /db_xref="HSSP:1JBG" FT /db_xref="InterPro:IPR000551" FT /db_xref="UniProtKB/TrEMBL:Q7U271" FT /protein_id="CAD93224.1" FT /translation="MAKNPKDGESRTFLISVAAELAGMHAQTLRTYDRLGLVSPRRTSG FT GGRRYSLHDVELLRQVQHLSQDEGVNLAGIKRIIELTSQVEALQSRLQEMAEELAVLRA FT NQRREVAVVPKSTALVVWKPRR" FT CDS complement(82173..92696) FT /transl_table=11 FT /gene="PPE8" FT /locus_tag="Mb0362c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0362c, PPE8, len: 3507 aa. Equivalent to Rv0355c FT and Rv0354c, len: 3300 aa and 141 aa, from Mycobacterium FT tuberculosis strain H37Rv, (99.8% identity in 3296 aa FT overlap and 100.0% identity in 125 aa overlap). PPE8, FT member of the Mycobacterium tuberculosis PPE family, FT similar to others e.g. AL009198|MTV004_5 from M. FT tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0, FT (40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: FT (39.0% identity in 3531 aa overlap); etc. Gene contains FT large number of clustered Major Polymorphic Tandem Repeats FT (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, FT E(): 0; MTCY48.17, E(): 0; MTCY98.0034c, E(): 0; FT MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; MTCY31.06c, E(): FT 5.6e-17; MTCY359.33, E(): 2.3e-16. PPE7, member of the FT Mycobacterium tuberculosis PPE family, similar to others FT e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 aa), FT FASTA scores: E(): 3.6e-11, (47.6% identity in 103 aa FT overlap). Possible continuation of ORF upstream, but no FT sequence error apparent. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 FT exist as 2 genes. In Mycobacterium bovis, a 2 bp insertion FT (*-ta) resulting in the absence of a stop codon between the FT 2 genes, leads to a single product." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7U270" FT /protein_id="CAD93225.1" FT /translation="MSFAVLPPEINSARLYVGAGLAPMLDAAAAWDGLADELGSAAASF FT SAVTAGLAGSSWLGAASTAMTGAAAPYLGWLSAAAAQAQQAATQTRLAAAAFEAALAAT FT VHPAIISANRALFVSLVVSNLLGQNAPAIAATEAAYEQMWAQDVAAMFGYHAGASAAVS FT ALTPFGQALPTVAGGGALVSAAAAQVTTRVFRNLGLANVGEGNVGNGNVGNFNLGSANI FT GNGNIGSGNIGSSNIGFGNVGPGLTAALNNIGFGNTGSNNIGFGNTGSNNIGFGNTGDG FT NRGIGLTGSGLLGFGGLNSGTGNIGLFNSGTGNVGIGNSGTGNWGIGNSGNSYNTGFGN FT SGDANTGFFNSGIANTGVGNAGNYNTGSYNPGNSNTGGFNMGQYNTGYLNSGNYNTGLA FT NSGNVNTGAFITGNFNNGFLWRGDHQGLIFGSPGFFNSTSAPSSGFFNSGAGSASGFLN FT SGANNSGFFNSSSGAIGNSGLANAGVLVSGVINSGNTVSGLFNMSLVAITTPALISGFF FT NTGSNMSGFFGGPPVFNLGLANRGVVNILGNANIGNYNILGSGNVGDFNILGSGNLGSQ FT NILGSGNVGSFNIGSGNIGVFNVGSGSLGNYNIGSGNLGIYNIGFGNVGDYNVGFGNAG FT DFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNIASGWNSGTGNSGLFNSGTNNV FT GIFNAGTGNVGIANSGTGNWGIGNPGTDNTGILNAGSYNTGILNAGDFNTGFYNTGSYN FT TGGFNVGNTNTGNFNVGDTNTGSYNPGDTNTGFFNPGNVNTGAFDTGDFNNGFLVAGDN FT QGQIAIDLSVTTPFIPINEQMVIDVHNVMTFGGNMITVTEASTVFPQTFYLSGLFFFGP FT VNLSASTLTVPTITLTIGGPTVTVPISIVGALESRTITFLKIDPAPGIGNSTTNPSSGF FT FNSGTGGTSGFQNVGGGSSGVWNSGLSSAIGNSGFQNLGSLQSGWANLGNSVSGFFNTS FT TVNLSTPANVSGLNNIGTNLSGVFRGPTGTIFNAGLANLGQLNIGSANLGDFNLGSGNV FT GSFNVFSGNQGSYNIGPANLGNYNIGFANLGNYNIGFGNAGDFNQGFANTGNNNIGFAN FT TGNNNIGIGLSGDNQQGFNFAGGWNSGTANIGLFNSGTNNVGIGNSGTGNWGIGNSGSG FT NTGIGNTGSTNTGFFNTGIVNTGVANAGSYNTGWYNTGDTNTGIANLGDFNTGFYNTGN FT FSTGFANQGDIATGAFITGDMGNGAFWRGDQQGLFSAGYRVHVPEIPAHVTVEVPVNIP FT ITASFTNTVYSGITLEQINFGFTIDIAGIPLLAGAISKAVLPPITGTGPAITVNIGDPG FT GSTAIRIPATASVGPFDVTFVNIAATTGFFNATTDPSSGFFNGGPGTVSGIANIGANIS FT GFQNVANSATSGFNNYGSLQSGLANLGDTVSGVFNTGIGAPANVSGMFNIGSNLAGFFH FT DQATGMSMFNLGLGNIGQFNVGFSNVGDSNAGLANIGSFNLGSGNLGSFNVFGGNQGSY FT NIGPANLGNYNIGLGNLGSYNFGFGNAGDFNLGFANTGNNNIGFANTGNNNIGIGLSGD FT NQQGFNFAGGWNSGSGNSGLFNSGTNNIGLFNSGTGNIGIGNSGTGNWGIANTGDTNTG FT IFNTGDVNTGLLNAGNVNTGIFNTGHYNTGSFNAGSFNTAGFNPGSYNTGYLNTGSYNT FT GLANSGDVNTGGFITGNYSNGFWWRGDYQGLAGISQTITVPDTAVPVKLHVPIFLDIPV FT TGTLGTFTVHGFRFPEITGDIFLIGIPFNAATLDAFSFPNISIVLPNIGINLGSGPDPL FT IDIAGTGGLLPIKIPLIDIPAAPGFGNSTTTPSSGFFNAGTGTVSGVGNVGSNSSGFFD FT LTSGSSGISGVQNFGELISGGFNFGNTVSGLVNASTLGLSMPANLSGGGNVGATVAGFV FT NNTQILNLGFGNVGSGNVGHGNIGDSNVGLGNLGNANVGHGNIGSFNVFSGNRGSYNIG FT PANLGNYNIGLGNLGSYNFGFGNAGDFNLGFANSGSNNIGFANTGNNNIGIGLSGHNQQ FT GFGSWNSGTANTGLFNSGTNNIGLFNSGTGNIGIGNSGIGNTGIGNPGVGNTGLGNSGT FT GNWGLWNPGTGNMGVANVGTYNTGGYNVGSTNTGIANVGIANTGSYNTGSTNTGSFNDG FT DFNTGFYNTGDYNTGFYNTGDVNTGAFIGGNFSNGAFWQSDHQGQWGAHYAITVPQIPL FT LNFSLNIPVNIPIHLDFGTLAVNGFQIPAITLRALGVTHFSVGPIIVPRIAGTLPVIDI FT NIGDPGGSSSIPITITSGAGPVVIPLLDIPPAPGFGNSTTGPSSGFFNSGTGSSSGFGN FT VGANNSGFWNTAFAGIGNSGLQNFGSLQSGWANLGNTVSGFYNTSAADFATPANLSGLS FT NVGADLTGVLRGPNGSTFNAGLANLGQFNVGSANLGSANLGSANLGNSNVGFGNIGNAN FT IGGANIGDFNVGIANTGPGLTAAVNNIGIGNTGNYNIGVGNTGNYNIGFGNTGNNNIGI FT GLSGDNQIGFGPLNAGIANMGLFNLGDNNFGMANAGNFNQGIANTGNNNIGLFNTGNNN FT VGIGLTGDGLSGFSSLNSGAGNTGFFNSGTANTGLFNSGTGNTGLFNSGTGNVGIGNMG FT TGGFGVGLSGDSQVGIGGTNSGSFNIGLFNSGTGNVGIGNSGTGNVGIGNTGTGNTGIG FT NSGNYNTGLLNAGLVNTGIANPGNHNTGLFNIGTFNTGIANPGHYNTGSYNTGSYNTGM FT ANAGDYGTGAFITGSMNNGLLWRADRQGLLAANYTITIERPAAFLNVDIPVNIPITGDI FT TNVSIPAITFPRIDASGSVDIGILSGTVLAPVGPITLHGGDASAPLDTPIEIDFGPSPA FT INLNIGKPDGSTVINIVGGAGAGPISIPIIDLRPAPGFFNATTGPSSGFLNWGAGSASG FT LLNFGNNSGLYNFATSSMGNSGFQNYGSLQSGWANLGNSISGIYNTGLGAPANVSGLLN FT IGTNLAGWLQNGPTETTFSVGLANLGFWNLGSANIGNYNLGSANIGVYNLGSANIGDFN FT LGSANIGDFNLGSANIGSSNIGFGNVGPGLTAAIGNIGFGNTGNGNIGIGNTGTGNIGF FT GNTGNGNIGIGLTGDTMTGFGGWNSGTGNIGLFNSGTGNIGFGNSGTGNWGIGNSGDYN FT TGIGNTGSTNSGFFNTGLVNTGIGNSGDYNTGLFNAGNTNTGSFNPGDYNTGGFNPGNY FT NTGYFNPGNSNTGFANSGDVNTGAFNSGNYSNGFFWRGDYQGLGGFAYQSAVSEIPWSY FT DIGSNIEIPIEGDINAITQDAFTIDEFEIPIKLRVSVCVIYIPFKGCVKHVSVTIPITT FT EHLGPYEIDASTINPDQPIDTAFTQTLDFAGSGTVGAFPFGFGWQQSPGFFNSTTTPSS FT GFFNSGAGGASGFLNDAAAAVSGLGNVFTETSGFFNAGGVGNSGFQNFGNLLSGWANLG FT NTVSGFYNTSMLDLATQALISGFGNHGARLSGILNNGSGP" FT CDS complement(92847..93491) FT /transl_table=11 FT /gene="Mb0363c" FT /locus_tag="Mb0363c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0363c, -, len: 214 aa. Equivalent to Rv0356c, len: FT 214 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 214 aa overlap). Conserved hypothetical FT protein, equivalent to AL023514|MLCB4_12 CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (218 aa), FT FASTA scores: opt: 1067, E(): 0, (73.4% identity in 214 aa FT overlap)." FT /db_xref="InterPro:IPR006683" FT /db_xref="UniProtKB/TrEMBL:Q7U269" FT /protein_id="CAD93226.1" FT /translation="MTDASVHPDELDPEYHHHGGFPEYGPASPGAGFGQFVATMRRLQD FT LAVAADPGDAVWDEAAERAAALVELLSPFEADEGKAPAGRTPGLPGMGSLLLPPWTVTR FT YGTDGVEMRGSFSRFHVGGNSAVHGGVLPLLFDHMFGMISHAAGRPISRTAFLHVDYRR FT ITPIDVPLIVRGRVTNTEGRKAFVCAELFDSDETLLAEGNGLMVRLLPGQP" FT CDS complement(93488..94786) FT /transl_table=11 FT /gene="purA" FT /locus_tag="Mb0364c" FT /product="PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA FT (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)" FT /EC_number="6.3.4.4" FT /note="Mb0364c, purA, len: 432 aa. Equivalent to Rv0357c, FT len: 432 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 432 aa overlap). Probable purA, FT adenylosuccinate synthase (EC 6.3.4.4), equivalent to FT AL023514|MLCB4_13 from ADENYLOSUCCINATE SYNTHETASE FT Mycobacterium leprae (432 aa), FASTA scores: opt: 2555, FT E(): 0, (87.9% identity in 431 aa overlap). Also highly FT similar to many bacterial adenylosuccinates synthetases FT e.g. P12283|PURA_ECOLI adenylosuccinates synthetase from FT Escherichia coli (431 aa), FASTA scores: E(): 0, (51.1% FT identity in 425 aa overlap); etc. BELONGS TO THE FT ADENYLOSUCCINATE SYNTHETASE FAMILY." FT /db_xref="GOA:P65881" FT /db_xref="HSSP:1ADE" FT /db_xref="InterPro:IPR001114" FT /db_xref="UniProtKB/Swiss-Prot:P65881" FT /protein_id="CAD93227.1" FT /translation="MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVL FT PTGENFALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISADAH FT LLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHKVEA FT ACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETVLLEG FT SQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSGPFPTE FT LFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLES FT VPVCVGYEIDGRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVL FT RLEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP" FT CDS 94877..95524 FT /transl_table=11 FT /gene="Mb0365" FT /locus_tag="Mb0365" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0365, -, len: 215 aa. Equivalent to Rv0358, len: FT 215 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 215 aa overlap). Conserved hypothetical FT protein, highly similar to AL023514|MLCB4_14 from FT Mycobacterium leprae (229 aa), FASTA scores: opt: 852, E(): FT 0, (62.9% identity in 229 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U268" FT /protein_id="CAD93228.1" FT /translation="MYTAENAPGVAVLLSGDADVPGPLTGLPTHQDNLDTVIGRYSRLI FT VVGADADLGAVLTRLLRTDRLDVEVGYVPRRRSPATRAYRLPAGRRAARRARCGVARRV FT PLIRDETGSVIVGRAQWLPAEEQALIHGEAVVDDTVLFDGDVAGVCIEPTLTLPGLRAA FT VDGAGKWRRWIGGRAAQLGTTGAAVLRDGVAAPRPVRRSTFYRNVEGWLLVR" FT CDS 95535..96314 FT /transl_table=11 FT /gene="Mb0366" FT /locus_tag="Mb0366" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0366, -, len: 259 aa. Equivalent to Rv0359, len: FT 259 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 259 aa overlap). Probable conserved FT integral membrane protein, highly similar to hypothetical FT or other membrane proteins e.g. AL133220|SCC75A_6|T50569 FT probable membrane protein from Streptomyces coelicolor (265 FT aa), FASTA scores: opt: 642, E(): 0, (43.1% identity in 248 FT aa overlap); P70995 HYPOTHETICAL 24.7 KD PROTEIN from FT Bacillus subtilis (219 aa), FASTA scores: E(): 1.5e-12, FT (31.3% identity in 192 aa overlap). Contains neutral zinc FT metallopeptidases, zinc-binding region signature FT (PS00142)." FT /db_xref="GOA:Q7U267" FT /db_xref="InterPro:IPR008915" FT /db_xref="UniProtKB/TrEMBL:Q7U267" FT /protein_id="CAD93229.1" FT /translation="MSETGQRESVRPSPIFLGLLGLTAVGGALAWLAGETVQPLAYAGV FT FVMVIAGWLVSLCLHEFGHAFTAWRFGDHDVAVRGYLTLDPRRYSHPMLSLGLPMLFIA FT LGGIGLPGAAVYVHTWFMTTARRTLVSLAGPTVNLALAMLLLAATRLLFDPIHAVLWAG FT VAFLAFLQLTALVLNLLPIPGLDGYAALEPHLRPETQRALAPAKQFALVFLLVLFLAPT FT LNGWFFGVVYWLFDLSGVSHRLAAAGSVLTRFWSIWF" FT CDS complement(96319..96756) FT /transl_table=11 FT /gene="Mb0367c" FT /locus_tag="Mb0367c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0367c, -, len: 145 aa. Equivalent to Rv0360c, len: FT 145 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 145 aa overlap). Conserved hypothetical FT protein, equivalent to FT AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c FT hypothetical protein from Mycobacterium leprae (137 aa), FT FASTA scores: opt: 793, E(): 0, (85.4% identity in 137 aa FT overlap). And similar to AL049754|SCH10_25c|T36537 FT hypothetical protein from Streptomyces coelicolor (143 aa), FT FASTA scores: opt: 497, E(): 3.2e-27, (55.8% identity in FT 138 aa overlap)." FT /db_xref="InterPro:IPR014487" FT /db_xref="UniProtKB/TrEMBL:Q7U266" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93230.1" FT /translation="MTKRTITPMTSMGDLLGPEPILLPGDSDAEAELLANESPSIVAAA FT HPSASVAWAVLAEGALADDKTVTAYAYARTGYHRGLDQLRRHGWKGFGPVPYSHQPNRG FT FLRCVAALARAAAAIGETDEYGRCLDLLDDCDPAARPALGL" FT CDS 96839..97666 FT /transl_table=11 FT /gene="Mb0368" FT /locus_tag="Mb0368" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0368, -, len: 275 aa. Equivalent to Rv0361, len: FT 275 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 275 aa overlap). Probable conserved FT membrane protein (has hydrophobic stretch from residues FT 132-156), equivalent to FT AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane FT protein from Mycobacterium leprae (292 aa), FASTA scores: FT opt: 1044, E(): 0, (58.6% identity in 292 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U265" FT /protein_id="CAD93231.1" FT /translation="MSNAPEPDRSAGESGSEPAGERSADPGEERTESYPLVPHDAETET FT VVITTSDNDAAVTQPEAQRERRFTAPGFDAKETQVIVTAHEAATEVFQTNQAPTTPPRM FT PTGMPPKTAVPQSIPPRTEATSVRQRTWGWALAVVVIVLALAAIAILGTVLLTRGKHSK FT MSQEDQVRQAIQSLDIAIQTGDLTALRSLTCGSTRDGYVDYDERDWAETYRRVSAAKQY FT PVIASIDQVVVNGAHAEANVTTFMAFDPQVRSTRSLDLQFRDDQWKICQSSSN" FT CDS 97888..99270 FT /transl_table=11 FT /gene="mgtE" FT /locus_tag="Mb0369" FT /product="POSSIBLE Mg2+ TRANSPORT TRANSMEMBRANE PROTEIN FT MGTE" FT /note="Mb0369, mgtE, len: 460 aa. Equivalent to Rv0362, FT len: 460 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 460 aa overlap). Possible mgtE, FT magnesium (Mg2+) transport transmembrane protein; FT C-terminal region is highly similar to MGTE|G780283 FT putative Mg2+ transporter from Providencia stuarti (314 FT aa), FASTA scores: E(): 0, (47.2% identity in 307 aa FT overlap) (N-terminus extends approx. 150 aa further FT upstream compared to P. stuarti ORF). Also similar in part FT to others e.g. AAK20879.1|AF334760_1|AF334760 putative Mg2+ FT transporter from Aeromonas hydrophila (455 aa); FT NP_231292.1|NC_002505 magnesium transporter from Vibrio FT cholerae (451 aa); NP_102305.1|NC_002678 Mg2+ transport FT protein from Mesorhizobium loti (454 aa); etc. Also similar FT to Rv1232c|MTV006.04c from Mycobacterium tuberculosis (435 FT aa). Extended hydrophobic segment spanning last 130 FT residues. BELONG TO THE MGTE FAMILY." FT /db_xref="GOA:Q7U264" FT /db_xref="InterPro:IPR006668" FT /db_xref="UniProtKB/TrEMBL:Q7U264" FT /protein_id="CAD93232.1" FT /translation="MSIRPAENSTLDIRHVIGIGTPKAVDLWLDVVTELPDRARELGSL FT SKAELGKLGPLLDGTNAVELFESIDDKLAAEALHAMDPSLAATFLEALDSDHAANILRE FT FKEPKREALLTLLPLERAMVLRGLLSWPEDCAAAHMVPETLTVRPNMTVSQAVASVRER FT ASGLRSDARTTAYVYVTDADSHLLGVIAFRALVLANPEQRVRELMGDDLIVVSPLTDKE FT LAAQTIMGHNLMAVPVVDADNRLLGIIAEDEAIDIAEEEATEDAERQGGSAPLEVPYLR FT ASPWLLWRKRAVWLLVLFAAEAYTGSVLRAFSDEMEAVIALAFFIPLLIGTGGNTGTQI FT ATTLVRAMATGQVRFRDVPAVLAKELSTGVLVGLTMAAAAVVRAWTLGVGPQVTLTVAL FT TVAAIVVWSSLVAAVLPPLLKKLRIDPAIVSGPMIATIVDGTGLLIYFLVAHLTLTELH FT GL" FT CDS complement(99282..100316) FT /transl_table=11 FT /gene="fba" FT /locus_tag="Mb0370c" FT /standard_name="fda" FT /product="PROBABLE FRUCTOSE-BISPHOSPHATE ALDOLASE FBA" FT /EC_number="4.1.2.13" FT /note="Mb0370c, fba, len: 344 aa. Equivalent to Rv0363c, FT len: 344 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 344 aa overlap). Probable fba FT (alternate gene name: fda), fructose bisphosphate aldolase FT (EC 4.1.2.13), equivalent to FT AL023514|MLCB4_18|O69600|ALF_MYCLE FRUCTOSE-BISPHOSPHATE FT ALDOLASE from Mycobacterium leprae (345 aa), FASTA scores: FT opt: 1995, E(): 0, (87.7% identity in 342 aa overlap). Also FT highly similar to others. BELONGS TO CLASS II FT FRUCTOSE-BISPHOSPHATE ALDOLASE FAMILY. COFACTOR: ZINC." FT /db_xref="GOA:P67476" FT /db_xref="HSSP:1ZEN" FT /db_xref="InterPro:IPR000771" FT /db_xref="UniProtKB/Swiss-Prot:P67476" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93233.1" FT /translation="MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAG FT SDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDS FT YVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIG FT VVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKL FT RPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQY FT AFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGK FT SLTH" FT CDS 100412..101095 FT /transl_table=11 FT /gene="Mb0371" FT /locus_tag="Mb0371" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0371, -, len: 227 aa. Equivalent to Rv0364, len: FT 227 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 227 aa overlap). Possible conserved FT transmembrane protein, equivalent to FT O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLCB4 FT _19 HYPOTHETICAL 24.3 KDA PROTEIN from Mycobacterium leprae FT (222 aa), FASTA scores: opt: 1027, E(): 0, (66.1% identity FT in 227 aa overlap). Shows strong similarity to FT DEDA_ECOLI|P09548 DedA PROTEIN protein from Escherichia FT coli FASTA scores: E(): 1.3e-28, (39.5% identity in 195 aa FT overlap). Similar also to Mycobacterium tuberculosis DedA FT protein Rv2637|MTCY441.0." FT /db_xref="GOA:Q7U263" FT /db_xref="InterPro:IPR015414" FT /db_xref="UniProtKB/TrEMBL:Q7U263" FT /protein_id="CAD93234.1" FT /translation="MSTAVTAMPDILDPMYWLGANGVFGSAVLPGILIIVFIETGLLFP FT LLPGESLLFTGGLLSASPAPPVTIGVLAPCVALVAVLGDQTAYFIGRRIGPALFKKEDS FT RFFKKHYVTESHAFFEKYGKWTIILARFVPIARTFVPVIAGVSYMRYPVFLGFDIVGGV FT AWGAGVTLAGYFLGSVPFVHMNFQLIILALVFVSLLPALVSAARVYRARRNAPQSDPDP FT LVLPE" FT CDS complement(101084..102214) FT /transl_table=11 FT /gene="Mb0372c" FT /locus_tag="Mb0372c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0372c, -, len: 376 aa. Equivalent to Rv0365c, len: FT 376 aa (start uncertain), from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 376 aa overlap). FT Conserved hypothetical protein, very similar to FT G388212|CAA35191.1, a truncated ORF immediately upstream of FT the Corynebacterium glutamicum fda gene encoding FT fructose-1,6-biphosphate aldolase (304 aa), FASTA scores: FT E(): 7.1e-19, (42.2% identity in 296 aa overlap)." FT /db_xref="GOA:Q7U262" FT /db_xref="InterPro:IPR014512" FT /db_xref="UniProtKB/TrEMBL:Q7U262" FT /protein_id="CAD93235.1" FT /translation="MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLFG FT SWHYWWQAHLLDCLVDAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLALA FT LERADRVAGVRRRRALPKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFLARY FT PDQYGKRLKRAEQMADWIDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLETELA FT VRTGPAARARHCARVHRLVAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALVATTLP FT GDSADDAAARDTARAIVLASAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGEQARSVR FT GAVHSSAIAERDLSVQLSGWMLMEAAHSAAAVSSLG" FT CDS complement(102239..102832) FT /transl_table=11 FT /gene="Mb0373c" FT /locus_tag="Mb0373c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0373c, -, len: 197 aa. Equivalent to Rv0366c, len: FT 197 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 197 aa overlap). Conserved hypothetical FT protein, showing weak similarity to FT HI1395|P44173|YD95_HAEIN HYPOTHETICAL PROTEIN from FT Haemophilus influenzae (140 aa), FASTA scores: opt: 152, FT E(): 0.0015, (27.0% identity in 126 aa overlap). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 FT Glycine radical signature." FT /db_xref="InterPro:IPR019777" FT /db_xref="UniProtKB/TrEMBL:Q7U261" FT /protein_id="CAD93236.1" FT /translation="MKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPD FT DPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSHPSKLELIRTARTAGYTVVLHVLVI FT PEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAGPRI FT VAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA" FT CDS complement(102861..103250) FT /transl_table=11 FT /gene="Mb0374c" FT /locus_tag="Mb0374c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0374c, -, len: 129 aa. Equivalent to Rv0367c, len: FT 129 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 129 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U260" FT /protein_id="CAD93237.1" FT /translation="MPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVS FT NQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEISAAIEERLSRTNYGDVLAAQGITT FT VALNDAGDIVEHRPDGTSVVLAATP" FT CDS complement(103331..104542) FT /transl_table=11 FT /gene="Mb0375c" FT /locus_tag="Mb0375c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0375c, -, len: 403 aa. Equivalent to Rv0368c, len: FT 403 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 403 aa overlap). Conserved hypothetical FT protein, showing some similarity to AJ224684|BJAJ4684_4 FT cooxS protein from Bradyrhizobium japonicum (422 aa), FASTA FT scores: opt: 341, E(): 4.3e-13, (27.4% identity in 387 aa FT overlap); Rv2425c|MTCY428_22 hypothetical protein from FT Mycobacterium tuberculosis FASTA score: (30.7% identity in FT 238 aa overlap). Contains PS00213 Lipocalin signature." FT /db_xref="InterPro:IPR002345" FT /db_xref="UniProtKB/TrEMBL:Q7U259" FT /protein_id="CAD93238.1" FT /translation="MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQL FT VPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRTPV FT AGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPFDQF FT DPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLLARIR FT PRRRPRRVLLLCDVSRSMQPYAAIYLHLMRAAVLRRAGGHPEVFAFSTSLTRLTSVLSH FT RSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDSDPPDVL FT VHALTRVRRRAELLVWLNPRAAHPEFQPRASSMAAALPYCDLFLPAHSLAGLHQLLLAL FT AGAR" FT CDS complement(104548..105063) FT /transl_table=11 FT /gene="Mb0376c" FT /locus_tag="Mb0376c" FT /product="POSSIBLE MEMBRANE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0376c, -, len: 171 aa. Equivalent to Rv0369c, len: FT 171 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 171 aa overlap). Possible membrane FT protein oxidoreductase (EC 1.-.-.-), similar to ORF 4 of FT the Pseudomonas thermocarboxydovorans protein of FT cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from FT Pseudomonas thermocarboxydovorans (171 aa), FASTA scores: FT opt: 226, E(): 9.8e-08, (31.3% identity in 166 aa overlap). FT Also similar to MTV036.05, MTV036.08, MTV036.09, and FT MTV026.10." FT /db_xref="GOA:Q7U258" FT /db_xref="InterPro:IPR010419" FT /db_xref="UniProtKB/TrEMBL:Q7U258" FT /protein_id="CAD93239.1" FT /translation="MPGAQLIGHEGDEYLGKVKVKVGPVTSEFSGKVHFVEQDRNQHRA FT VFDAKGKEARGTGNAAATVAAQLHEVGERTRVTVDTDLKIVGKLAQFGSGMLQQVSEKL FT LGQFVDSLEAELAAQSSESPQGTPPATEAAPIDLLQLADGGQLKKYGSALLAALTVLLL FT IWVLRRRR" FT CDS complement(105164..106060) FT /transl_table=11 FT /gene="Mb0377c" FT /locus_tag="Mb0377c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0377c, -, len: 298 aa. Equivalent to Rv0370c, len: FT 298 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 298 aa overlap). Possible oxidoreductase FT (EC 1.-.-.-), similar to many hypothetical proteins, but FT also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL FT gene cluster from Pseudomonas/Oligotropha carboxidovorans FT (295 aa), FASTA scores: opt: 851, E(): 0, (48.2% identity FT in 282 aa overlap); AJ224684|BJAJ4684_3 cooxS from FT Bradyrhizobium japonicum (302 aa), FASTA scores: opt: 881, FT E(): 0, (47.6% identity in 290 aa overlap). Also highly FT similar to MTCY428_21 from Mycobacterium tuberculosis. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7U257" FT /db_xref="InterPro:IPR019825" FT /db_xref="UniProtKB/TrEMBL:Q7U257" FT /protein_id="CAD93240.1" FT /translation="MTFASPDDVIRRFDEQNYLLDTGTASAIYLAVTLGRPLLLEGEPG FT VGKTTAAKTLAVVLDTTLIRLQCYEGLTANEALYDWNYQRQLLSIRLAEARGKGISDIS FT EADLYTEAYLVDRPILRCVRHRGPTPPVLLIDEIDRADDEFEALLLEFLGESAVTVPEL FT GTFLAECPPIAVLTSNRSRDLHDALRRRCLYHWIDYPEPDRAAAIVRRTVPGATAPLIE FT NATQFVCTARDLDLDKPPGVAETIDWVAALVALGVADLTAADSSPALASLGALAKTPDD FT RTQIRDAYQAFTECSHA" FT CDS complement(106057..106650) FT /transl_table=11 FT /gene="Mb0378c" FT /locus_tag="Mb0378c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0378c, -, len: 197 aa. Equivalent to Rv0371c, len: FT 197 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 197 aa overlap). Conserved hypothetical FT protein, similar to other hypothetical proteins e.g. FT AL132824|SCAH10.09c|CAB60163.1|AL132824 hypothetical FT protein from Streptomyces coelicolor (207 aa), FASTA FT scores: opt: 247, E(): 4.5e-09, (32.3% identity in 195 aa FT overlap). Also weak similarity with FT YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE FT from Bacillus subtilis (197 aa), FASTA scores: opt: 217, FT E(): 2.5e-08, (27.0% identity in 174 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U256" FT /protein_id="CAD93241.1" FT /translation="MTATQITGVVLAAGRSNRLGTPKQLLPYRDTTVLGATLDVARQAG FT FDQLILTLGGAASAVRAAMALDGTDVVVVEDVERGCAASLRVALARVHPRATGIVLMLG FT DQPQVAPATLRRIIDVGPATEIMVCRYADGVGHPFWFSRTVFGELARLHGDKGVWKLVH FT SGRHPVRELAVDGCVPLDVDTWDDYRRLLESVPS" FT CDS complement(106647..107402) FT /transl_table=11 FT /gene="Mb0379c" FT /locus_tag="Mb0379c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0379c, -, len: 251 aa. Equivalent to Rv0372c, len: FT 251 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 251 aa overlap). Conserved hypothetical FT protein, showing some similarity with FT CAB76248.1|X82447|COXF CoxF protein from FT Pseudomonas/Oligotropha carboxidovorans (280 aa); FT AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum FT (176 aa), FASTA scores: opt: 186, E(): 1.6e-05, (41.1% FT identity in 95 aa overlap). Also similar to upstream ORF FT Rv0376c from Mycobacterium tuberculosis (380 aa), FASTA FT scores: E(): 6.8e-07, (31.0% identity in 277 aa overlap)." FT /db_xref="InterPro:IPR003777" FT /db_xref="UniProtKB/TrEMBL:Q7U255" FT /protein_id="CAD93242.1" FT /translation="MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGTI FT EGFVGGHCAQNSVRKAAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGSLE FT IFLTPQLPAPLIQIYGETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASHSGP FT EAEIIRTALDNGVGYVGLVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTPAEIA FT VSIAAELIATLRGGGPRGRKALADENGGA" FT CDS complement(107421..109820) FT /transl_table=11 FT /gene="Mb0380c" FT /locus_tag="Mb0380c" FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (LARGE FT CHAIN)" FT /EC_number="1.2.99.2" FT /note="Mb0380c, -, len: 799 aa. Equivalent to Rv0373c, len: FT 799 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 799 aa overlap). Probable carbon FT monoxide dehydrogenase, large chain (EC 1.2.99.2), highly FT similar to others e.g. AAD00363.1| U80806|CUTL carbon FT monoxide dehydrogenase large subunit CutL protein from FT Hydrogenophaga pseudoflava (803 aa); FT S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA FT carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) FT (cut operon) from Pseudomonas thermocarboxydovorans (842 FT aa); C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL FT carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) FT (cluster coxMSL) from Pseudomonas/Oligotropha FT carboxydovorans (809 aa), FASTA scores: opt: 2484, E(): 0, FT (56.0% identity in 804 aa overlap); etc." FT /db_xref="GOA:Q7U254" FT /db_xref="HSSP:1FFV" FT /db_xref="InterPro:IPR012780" FT /db_xref="UniProtKB/TrEMBL:Q7U254" FT /protein_id="CAD93243.1" FT /translation="MTTIESRPPSPEDLADNAQQPCGHGRMMRKEDPRFIRGRGTYVDD FT VALPGMLHLAILRSPYAHARIVRIDVTAAQAHPKVKAVVTGADLAAKGLAWMPTLANDV FT QAVLATDKTRFQGQEVASVVAEDRYSARDACELVDVDYEPRDPVVDARTALDPSAPVIR FT TDLEGKSDNHIFDWETGDAAATEAVFAKADVVVQQEIVYPRVHPAPMETCGAVADLDPV FT TGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKVPIYPGYVCAIVAS FT LLLDKPVKWMEDRSENLTSTGFARDYIMVGEIAANRDGKILAIRSNVLADHGAFNAQAA FT PAKYPAGFFGVFTGSYDIEAAYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCL FT AFELKMDPAELRLRNLLRPNQFPYQSKTGWVYDSGDYETTMRKAMNMIGYEALRAEQKQ FT RRARGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVLRLSVQTQGQ FT GHETTFAQIVAEELGIAPDDIEVVHGDTDQTPFGLGTYGSRSTPVSGGAAALVARKVRD FT KAKIIASGMLEVSVADLQWEKGKFHVKGDPSAAVTIADIAMRAHGAGDLPEGIEGGLDA FT EVCYNPSNLTYPYGAYFCVVDIDPGTAVVKVRRFLAVDDCGTRINPMIIEGQVHGGIVD FT GIGMALMEMIAFDEDGNCLGGSLMDYLIPTALEVPHLETGHTVTPSPHHPIGAKGIGES FT ATVGSPPAVVNAVVDALAPFGVRHADMPLTPSRVWEAMQGRATPPI" FT CDS complement(109817..110296) FT /transl_table=11 FT /gene="Mb0381c" FT /locus_tag="Mb0381c" FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (SMALL FT CHAIN)" FT /EC_number="1.2.99.2" FT /note="Mb0381c, -, len: 159 aa. Equivalent to Rv0374c, len: FT 159 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 159 aa overlap). Probable carbon FT monoxide dehydrogenase, small chain (EC 1.2.99.2), highly FT similar to others e.g. FT B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide FT dehydrogenase small chain (EC 1.2.99.2) from FT Pseudomonas/Oligotropha carboxydovorans (166 aa), FASTA FT scores: opt: 662, E(): 0, (59.3% identity in 150 aa FT overlap); CAA12063.1|AJ224684 putative carbon monoxide FT dehydrogenase small subunit from Bradyrhizobium japonicum FT (161 aa); S49123|509390|CAA54901.1|X77931|CUTC FT carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) FT from Pseudomonas thermocarboxydovorans (163 aa); etc." FT /db_xref="GOA:Q7U253" FT /db_xref="HSSP:1FFV" FT /db_xref="InterPro:IPR001041" FT /db_xref="UniProtKB/TrEMBL:Q7U253" FT /protein_id="CAD93244.1" FT /translation="MQVNMTVNGEPVTAEVEPRMLLVHFLRDQLRLTGTHWGCDTSNCG FT TCVVEVDGVPVKSCTMLAVMASGHSIRTVEGLAGPDGQLDPVQEGFMRCHGLQCGFCTP FT GMLITARALLDRNPDPDEQTIREAISGQICRCTGYTTIVRSIQWAAAHQTVKAQS" FT CDS complement(110311..111171) FT /transl_table=11 FT /gene="Mb0382c" FT /locus_tag="Mb0382c" FT /product="PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM FT CHAIN)" FT /EC_number="1.2.99.2" FT /note="Mb0382c, -, len: 286 aa. Equivalent to Rv0375c, len: FT 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 286 aa overlap). Probable carbon FT monoxide dehydrogenase, medium chain (EC 1.2.99.2), similar FT to others e.g. AAD00361.1|U80806|CUTM carbon monoxide FT dehydrogenase middle subunit from Hydrogenophaga FT pseudoflava (287 aa); S49122|509389|CAA54900.1|X77931|CUTB FT carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) FT from Pseudomonas thermocarboxydovorans (287 aa); FT A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH FT carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) FT from Pseudomonas/Oligotropha carboxydovorans (288 aa), FT FASTA scores: opt: 594, E(): 0, (37.5% identity in 277 aa FT overlap); etc." FT /db_xref="GOA:Q7U252" FT /db_xref="HSSP:1FFV" FT /db_xref="InterPro:IPR016169" FT /db_xref="UniProtKB/TrEMBL:Q7U252" FT /protein_id="CAD93245.1" FT /translation="MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEYLVDINDLA FT PELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIFRDAERVIADPVVRNRGTL FT GGSLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAIDDFLVGPYETALAHNEVLIEVR FT IPLRHNTSSAYAKVERRVGDWAITAAGAAVTLDGQTILAARVGLTAVNPDPVALAELSA FT GLVGQPATEEVFAEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGRVLGAP FT AAPEA" FT CDS complement(111247..112389) FT /transl_table=11 FT /gene="Mb0383c" FT /locus_tag="Mb0383c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0383c, -, len: 380 aa. Equivalent to Rv0376c, len: FT 380 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 380 aa overlap). Conserved hypothetical FT protein, highly similar to FT T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical FT protein from Streptomyces coelicolor (395 aa); and FT AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from FT Arthrobacter nicotinovorans (377 aa). And similar to other FT conserved hypothetical proteins e.g. FT NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical FT protein from Mesorhizobium loti (245 aa). Note that FT C-terminus shows similarity with C-termini of FT CAB76248.1|X82447|COXF CoxF protein from FT Pseudomonas/Oligotropha carboxidovorans (280 aa); FT CAB76250.1|X82447|COXI CoxI protein from FT Pseudomonas/Oligotropha carboxidovorans (330 aa); and FT AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum FT (176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in FT 138 aa overlap). Also some partial similarity with FT AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum FT (107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3% FT identity in 92 aa overlap); E1184330|Z99120|YURF YURF FT PROTEIN from Bacillus subtilis (330 aa), FASTA scores: opt: FT 170, E(): 2.9e- 16, (27.5% identity in 345 aa overlap). FT Also similar to downstream ORF Rv0372c from Mycobacterium FT tuberculosis (251 aa), FASTA scores: E(): 2.1e-06, (30.7% FT identity in 277 aa overlap)." FT /db_xref="InterPro:IPR003777" FT /db_xref="UniProtKB/TrEMBL:Q7U251" FT /protein_id="CAD93246.1" FT /translation="MAIWAAGDTAGVATVVRTLRSAPRPPGAAMVVAPDGSVSGSVSGG FT CVEGAVYELAAEVAQTGIPRLEHYGVSDDTAFAVGLTCGGIIDVFVEPVSRATFPELGE FT LADDIGAQRPVAIATVIAHPDERRVGRRLVIRPDTKSPVTGSLGSARADAAVIDDARGL FT LAVGRSEILEYGPDGQRRGEGMEVFVSSHAPRPRMLVFGAIDFAAALARQGSFLGYRVT FT VCDARAVFATPARFPTADDVVVAWPHRYLAAQAEAGGIDERTVICVLTHDPKFDVPVLE FT VALRLGVGYVGAMGSRKTHDDRMDRLRAAGLTDAELSRLSSPIGLDLGARTPEETAVSI FT AADIIARRWGGGGRPLADIAGRIHHDAQVAGEFKDYLTRH" FT CDS 112438..113403 FT /transl_table=11 FT /gene="Mb0384" FT /locus_tag="Mb0384" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LYSR-FAMILY)" FT /note="Mb0384, -, len: 321 aa. Equivalent to Rv0377, len: FT 321 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 321 aa overlap). Probable transcription FT regulator, lysR family, showing similarity with many FT hypothetical transcriptional regulators lysR homolog e.g. FT P32484|YEIE_ECOLI|M89774 HYPOTHETICAL TRANSCRIPTIONAL FT REGULATOR from Escherichia coli (293 aa), FASTA scores: FT opt: 265, E(): 4.9e-11, (28.6% identity in 266 aa overlap). FT Also similar to Rv2282c from Mycobacterium tuberculosis. FT Contains PS00044 bacterial regulatory protein lysR family FT signature. SEEMS TO BELONG TO THE LYSR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7U250" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7U250" FT /protein_id="CAD93247.1" FT /translation="MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMHVAALRKELDD FT PLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTAIEVTEAAHGRRLLRIAASSAFAEHA FT APGLIELFSSRADDLSVELSVHPTSRFRELICSRAVDIAIGPASESSIGSDGSIFLRPF FT LKYQIITVVAPNSPLAAGIPMPALLRHQQWMLGPSAGSVDGEIATMLRGLAIPESQQRI FT FQSDAAALEEVMRVGGATLAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLAPSARQ FT PAVSELVGFISTPRCIQAMIRGSGVGVTRFRPKVHVTLWS" FT CDS 113654..113875 FT /transl_table=11 FT /gene="Mb0385" FT /locus_tag="Mb0385" FT /product="CONSERVED HYPOTHETICAL GLYCINE RICH PROTEIN" FT /note="Mb0385, -, len: 73 aa. Equivalent to Rv0378, len: 73 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 73 aa overlap). Conserved hypothetical gly-rich FT protein, showing some similarity to M. tuberculosis PE_PGRS FT family; also similar to MTCY06H11_16|Z85982 hypothetical FT glycine-rich 88.5 KD protein (1011 aa), FASTA scores: opt: FT 237, E(): 0.0032, (58.7% identity in 63 aa overlap); FT MTV043_25." FT /db_xref="UniProtKB/TrEMBL:Q7U249" FT /protein_id="CAD93248.1" FT /translation="MSGRWEAGNADGNGGSAGLIGSGGAGGDGGSGGATGAGGEGGDAG FT ASGSINGNAGDPGNSGERGAVGKPGAPG" FT CDS 113994..114209 FT /transl_table=11 FT /gene="secE2" FT /locus_tag="Mb0386" FT /product="POSSIBLE PROTEIN TRANSPORT PROTEIN SECE2" FT /note="Mb0386, secE2, len: 71 aa. Equivalent to Rv0379, FT len: 71 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 71 aa overlap). Possible secE2, protein FT transport protein, showing similarity with FT P27340|S61G_SULSO|SECE PREPROTEIN TRANSLOCASE SECE SUBUNIT FT (PROTEIN TRANSPORT PROTEIN SEC61 GAMMA SUBUNIT HOMOLOG) FT from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt: FT 79, E(): 4.7. (30.3% identity in 66 aa overlap); and FT hypothetical proteins e.g. Q9HPW4|VNG1446H HYPOTHETICAL FT PROTEIN from Halobacterium sp. strain NRC-1 (77 aa); FT Q9I794|PA0038 HYPOTHETICAL PROTEIN from Pseudomonas FT aeruginosa (71 aa); etc. Also highly similar to FT U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis FT protein from a patient isolate (116 aa), FASTA scores: opt: FT 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap). Note FT that for Rv0379|MTV036.14, a translation initiation region FT different to the one in U85467|MTU85467_1 was chosen. COULD FT BE A PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION FT APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, FT SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732." FT /db_xref="InterPro:IPR009923" FT /db_xref="UniProtKB/TrEMBL:Q7U248" FT /protein_id="CAD93249.1" FT /translation="MSVYKVIDIIGTSPTSWEQAAAEAVQRARDSVDDIRVARVIEQDM FT AVDSAGKITYRIKLEVSFKMRPAQPR" FT CDS complement(114285..114836) FT /transl_table=11 FT /gene="Mb0387c" FT /locus_tag="Mb0387c" FT /product="POSSIBLE RNA METHYLTRANSFERASE (RNA METHYLASE)" FT /EC_number="2.1.1.-" FT /note="Mb0387c, -, len: 183 aa. Equivalent to Rv0380c, len: FT 183 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 183 aa overlap). Possible RNA FT methyltransferase (EC 2.1.1.-), equivalent to FT CAC32002.1|AL583925 possible RNA methyltransferase from FT Mycobacterium leprae (182 aa). Also some similarity with FT others methyltransferases e.g. FT P19396|TRMH_ECOLI|78514|JV0043 TRNA FT (GUANOSINE-2'-O-)-METHYLTRANSFERASE (TRNA FT METHYLTRANSFERASE) from Escherichia coli (229 aa), FASTA FT scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa FT overlap). Also similar to Rv0881, Rv3579c, Rv1644 from FT Mycobacterium tuberculosis." FT /db_xref="GOA:Q7U247" FT /db_xref="InterPro:IPR001537" FT /db_xref="UniProtKB/TrEMBL:Q7U247" FT /protein_id="CAD93250.1" FT /translation="MLLRDGDARNVVDAYRYWTREAIIADIDTRRHPLHVAIENFGHDA FT NIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRLCHHDSTTGLLEFAAGAGLTV FT VAVDNVPGAARLEQTALPRECLLLFGQEGPGITDDARAGAAVTVSIAQFGSTRSINAGV FT AAGIAMHAWIRQHADLGRAW" FT CDS complement(114932..115840) FT /transl_table=11 FT /gene="Mb0388c" FT /locus_tag="Mb0388c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0388c, -, len: 302 aa. Equivalent to Rv0381c, len: FT 302 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 302 aa overlap). Hypothetical unknown FT protein. Equivalent to AAK44616.1 from Mycobacterium FT tuberculosis strain CDC1551 (254 aa) but longer 48 aa." FT /db_xref="UniProtKB/TrEMBL:Q7U246" FT /protein_id="CAD93251.1" FT /translation="MRILVAWATCGAVVLSGLTGCSGSSHSGRTYGAQSARTGESLAVL FT GWNMSVSNLRWSGDYVLIDVDASPTDPHAPHAKPEDIRFGLYGALAHPMESAALGSCGD FT AMAHVRDVVSPLSAPAGRLTGTVCLGPLKERSAVRGVYTYSPRDRIPGTAAAYPAAFPV FT GMLPTNQNDAGLVVKTTSVSAWRADGMQLGKPQLGDPVAFTGNGYMLLGLEVDAVPDRY FT RDDSAARGGPMMLLAAPTLPGRGLSPACATYGSSVLILPDALLDAVHISASLCTQGEIN FT EALLYATVATVGTHAALWTSR" FT CDS complement(115858..116397) FT /transl_table=11 FT /gene="pyrE" FT /locus_tag="Mb0389c" FT /product="PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE FT (OPRT) (OPRTASE)" FT /EC_number="2.4.2.10" FT /note="Mb0389c, pyrE, len: 179 aa. Equivalent to Rv0382c, FT len: 179 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 179 aa overlap). Probable pyrE, orotate FT phosphoribosyltransferase (EC 2.4.2.10), equivalent to FT CAC32004.1|AL583925 probable purine/pyrimidine FT phosphoribosyltransferase from Mycobacterium leprae (179 FT aa). Also highly similar to many others e.g. FT T36540|4753874|CAB42037.1|AL049754|SCH10.28c probable FT orotate phosphoribosyltransferase from Streptomyces FT coelicolor (182 aa); FT H69115|2622996|AAB86326.1|AE000938_10|MTH1860 probable FT orotate phosphoribosyltransferase from Methanobacterium FT thermoautotrophicum (180 aa), FASTA scores: opt: 389, E(): FT 2.7e-20, (40.7% identity in 172 aa overlap); FT O08359|PYRE_SULAC|2065444|CAA73352.1|Y12822 OROTATE FT PHOSPHORIBOSYLTRANSFERASE from Sulfolobus acidocaldarius FT (197 aa); etc. Note that also similar to other puridine FT 5'-monophosphate synthases (umpA genes; UMP synthases), FT generally in N-terminus that corresponds to orotate FT phosphoribosyltransferase activity. Contains PS00589 PTS FT HPR component serine phosphorylation site signature. FT BELONGS TO THE PURINE/PYRIMIDINE PHOSPHORIBOSYLTRANSFERASE FT FAMILY. Note that previously known as umpA." FT /db_xref="GOA:P0A5U1" FT /db_xref="InterPro:IPR000836" FT /db_xref="UniProtKB/Swiss-Prot:P0A5U1" FT /protein_id="CAD93252.1" FT /translation="MAGPDRAELAELVRRLSVVHGRVTLSSGREADYYVDLRRATLHHR FT ASALIGRLMRELTADWDYSVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKAHGMQR FT LIEGSEVTGQRVLVVEDTSTTGNSALTAVHAVQDVGGEVVGVATVVDRATGAAEAIEAE FT GLRYRSVLGLADLGLD" FT CDS complement(116478..117332) FT /transl_table=11 FT /gene="Mb0390c" FT /locus_tag="Mb0390c" FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT /note="Mb0390c, -, len: 284 aa. Equivalent to Rv0383c, len: FT 284 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 284 aa overlap). Possible conserved FT secreted protein, with hydrophobic stretch in N-terminus FT and Pro-rich C-terminus. Equivalent to CAC32006.1|AL583925 FT possible secreted protein from Mycobacterium leprae (286 FT aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U245" FT /protein_id="CAD93253.1" FT /translation="MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFDY FT ERESTEILKRWTRGVMSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGTNV FT VVDLRLKGLKEPRESDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAEIMW FT NEQNWTLVSMPIASTRAQWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAAPGRP FT VAPGGPAELPPRRAQPDPATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNGQQATN FT YQH" FT CDS complement(117473..120019) FT /transl_table=11 FT /gene="clpB" FT /locus_tag="Mb0391c" FT /standard_name="htpM" FT /product="PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN FT B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1)" FT /EC_number="3.-.-.-" FT /note="Mb0391c, clpB, len: 848 aa. Equivalent to Rv0384c, FT len: 848 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 848 aa overlap). Probable clpB FT (alternate gene name: htpM), endopeptidase ATP-binding FT protein, chain B (EC 3.-.-.-), equivalent to FT AC32007.1|AL583925 heat shock protein from Mycobacterium FT leprae (848 aa). Also highly similar to others e.g. FT P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 CLPB FT PROTEIN (heat-inducible expression) from Corynebacterium FT glutamicum (852 aa), FASTA scores: opt: 4113, E(): 0, FT (74.5% identity in 846 aa overlap); FT T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c FT probable ATP-dependent proteinase ATP-binding chain from FT Streptomyces coelicolor (853 aa); FT P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB PROTEIN FT (HEAT SHOCK PROTEIN F84.1) from Escherichia coli strains FT K12 and O157:H7 (857 aa); etc. Also similar to Rv3596c|ClpC FT from Mycobacterium tuberculosis. Contains PS00870 and FT PS00871 Chaperonins clpA/B signatures and two PS000017 FT ATP/GTP-binding site motives A (P-loop). BELONGS TO THE FT CLPA/CLPB FAMILY. Contains probable coiled-coil domain from FT aa 411-503." FT /db_xref="GOA:P63287" FT /db_xref="HSSP:1JBK" FT /db_xref="InterPro:IPR004176" FT /db_xref="UniProtKB/Swiss-Prot:P63287" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93254.1" FT /translation="MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDGI FT AAPLLEAVGVEPATVRAETQRLLDRLPQATGASTQPQLSRESLAAITTAQQLATELDDE FT YVSTEHVMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQALQK FT YSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQR FT IVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELH FT TIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEYRKHIEKDAALERRFQQVYVG FT EPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAA FT SRLRMEIDSRPVEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAE FT LTTRWQNEKNAIEIVRDLKEQLEALRGESERAERDGDLAKAAELRYGRIPEVEKKLDAA FT LPQAQAREQVMLKEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMEDELGKRVIGQK FT AAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFLFDDERAMVRID FT MSEYGEKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQ FT VLDEGRLTDGHGRTVDFRNTILILTSNLGSGGSAEQVLAAVRATFKPEFINRLDDVLIF FT EGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGFDPVYGARPLRRLVQ FT QAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSLILG" FT CDS 120152..121324 FT /transl_table=11 FT /gene="Mb0392" FT /locus_tag="Mb0392" FT /product="PROBABLE MONOOXYGENASE" FT /EC_number="1.-.-.-" FT /note="Mb0392, -, len: 390 aa. Equivalent to Rv0385, len: FT 390 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 390 aa overlap). Probable monooxygenase FT (EC 1.-.-.-), similar to T37003|5738846|CAB52917.1|AL109949 FT probable flavohemoprotein from Streptomyces coelicolor (435 FT aa); and similar in part (C-termini) to various FT monooxygenases e.g. P19734|DMPP_PSESP|94993|F37831 PHENOL FT HYDROXYLASE P5 PROTEIN (PHENOL 2-MONOOXYGENASE P5 FT COMPONENT) (EC 1.14.13.7) from Pseudomonas putida (353 aa), FT FASTA scores: opt: 363, E(): 4.2e-16, (31.8% identity in FT 255 aa overlap); S47292|2120861|pir|S70085 phenol FT 2-monooxygenase (EC 1.14.13.7) chain mopP from FT Acinetobacter calcoaceticus (350 aa); FT P21394|XYLA_PSEPU|94933|B37316 XYLENE MONOOXYGENASE FT ELECTRON TRANSFER COMPONENT (EC 1.18.1.3) [INCLUDES: FT FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE] from Pseudomonas FT putida plasmid pWW0 (350 aa); FT AAC38360.1|AF043544|NtnMA|ntnA reductase component of FT 4-nitrotoluene monooxygenase from Pseudomonas sp. (328 aa); FT etc." FT /db_xref="GOA:Q7U244" FT /db_xref="InterPro:IPR012292" FT /db_xref="UniProtKB/TrEMBL:Q7U244" FT /protein_id="CAD93255.1" FT /translation="MGLEDRDALRVLQNAFKLDDPELVRRFYAHWFALDASVRDLFPPD FT MGAQRAAFGQALHWVYGELVAQRAEEPVAFLAQLGRDHRKYGVLPTQYDTLRRALYTTL FT RDYLGHPSRGAWTDAVDEAAGQSLNLIIGVMSGAADADDAPAWWDGTVVEHIRVSRDLA FT VARLQLDRPLHYYPGQYVNVHVPQCPRRWRYLSPAIPADPNGRIEFHVRVVPGGLVSNA FT IVGETRPGDRWRLSGPHGAFRVDRDGGDVLMVAGSTGLAPLRALIIDLSRFAVNPRVHL FT FFGARYACELYDLPTLWQIAAHNPWLSVSPVSEYNGDPAWAADYPDVSAPRGLHVRQTG FT RLPDVVSRYGGWGDRQILICGGPAMVRATKAALIAKGAPPERIQHDPLSR" FT CDS 121428..124685 FT /transl_table=11 FT /gene="Mb0393" FT /locus_tag="Mb0393" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY LUXR/UHPA-FAMILY)" FT /note="Mb0393, -, len: 1085 aa. Equivalent to Rv0386, len: FT 1085 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1085 aa overlap). Probable regulatory FT protein, LuxR/uhpA family, highly similar to FT CAC30706.1|AL583923 possible transcriptional regulator from FT Mycobacterium leprae (1106 aa). Also similar in part to FT other regulatory proteins e.g. CAB95788.1|AL359949 putative FT multi-domain regulatory protein from Streptomyces FT coelicolor (780 aa); N-terminus of CAB92369.1|AL356612 FT putative AfsR-like regulatory protein from Streptomyces FT coelicolor (1114 aa); N-terminus of FT NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional FT regulator from Mesorhizobium loti (952 aa); FT AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces FT coelicolor (993 aa), FASTA scores: opt: 224, E() : 1.1e-06, FT (26.1% identity in 867 aa overlap); etc. Also similar to FT many putative Mycobacterium tuberculosis regulatory FT proteins e.g. AL0212|MTV008_44 (1137 aa), FASTA scores: FT opt: 3756, E(): 0, (56.7% identity in 1089 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop), FT PS00622 Bacterial regulatory proteins, luxR family FT signature and probable helix-turn-helix motif at aa FT 1042-1063 (Score 1025, +2.68 S D). BELONGS TO THE LUXR/UHPA FT FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7U243" FT /db_xref="HSSP:1JE8" FT /db_xref="InterPro:IPR000767" FT /db_xref="UniProtKB/TrEMBL:Q7U243" FT /protein_id="CAD93256.1" FT /translation="MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSGV FT IAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALRDE FT GNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSRPER FT VMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVTLTGA FT GGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRSTTDTV FT LRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEVSYRVPS FT LSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAARLRSMTLD FT EIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAVFVGCFFVD FT DAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYALEKLSEAGE FT VDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNRENSDTEGALA FT LASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADKALLDIFVDAAA FT GMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAEAIDLARAVDDRW FT RLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCRWCLGYAQLMRGEL FT AAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARAAADAALEAAELGEY FT FAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQRAFNAQAALAGGDLS FT AARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAHKALACAAESGAHLDLP FT DVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYRSDYVQSVTALRDAMGEK FT DFAAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPTEIDVVRLVGEGLANKDIA FT TRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT" FT CDS complement(124689..126020) FT /transl_table=11 FT /gene="PPE9" FT /locus_tag="Mb0394c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0394c, PPE9, len: 443 aa. Equivalent to Rv0388c FT and Rv0387c, len: 180 aa and 244 aa, from Mycobacterium FT tuberculosis strain H37Rv, (95.1% identity in 164 aa FT overlap and 100.0% identity in 244 aa overlap). Rv0388c: FT Member of the Mycobacterium tuberculosis PPE family, highly FT similar to others e.g. MTCY10G2_10|Z92539 from FT Mycobacterium tuberculosis (391 aa), FASTA scores: opt: FT 667, E(): 0, (58.3% identity in 180 aa overlap) but much FT shorter. Rv0387c: conserved hypothetical protein, showing FT some similarity to MTCI237.20c, and M17282|HUMEL20_1 Human FT elastin gene, exon 1, Elastin (687 aa), FASTA scores: opt: FT 193, E(): 0.35, (34.4% identity in 189 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 FT separate genes. In Mycobacterium bovis, 3 different base FT substitutions, the first of 14 bases, the second of 8 bases FT (tctacagt-gctacagg), and lastly of 28 bases, leads to a FT longer single product." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7U242" FT /protein_id="CAD93257.1" FT /translation="MDFGALPPEINSARIYSGPGSRPLMQAAAAWQRLANELTATAASY FT SSVISGLTGDDWLGPSALSMAAAAVPYVAWMRATAASAEQAAAQAVAAANAYESAYAAT FT VPPTVIAANRRTMLSLVKTNVFGQNTPAIATSEAQYGAMWAQDIVAMEGYAGASAAASQ FT LPPFTPPPATTSGAGSLSDAAATAAQAVVPAAAATDVSLLPTLQSFLPPPFDAIPNPIE FT DLDVLVAAAVAVAAGSLGVSAAQLGEIYRHDVVDEAQKAPHCPAESDQTPAGAAGDGDL FT PEVGGRVTSPPQPPVAALTGYSANIGGLSVPHSWNLPPAVRQVAAMFPGATPMYMTGSS FT DGSYAGLAAAGLAGTGLAGLAARGGSAPTPAAAAPAGAGGAGPAATRPAAQQTPAVPAA FT AAGSAIPGLPPGLPPGVVANLAATLAAIPGATIIVVPPSPNANQ" FT CDS 126354..127613 FT /transl_table=11 FT /gene="purT" FT /locus_tag="Mb0395" FT /product="PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FT FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) FT (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) FT (FORMATE-DEPENDENT GAR TRANSFORMYLASE)" FT /EC_number="2.1.2.-" FT /note="Mb0395, purT, len: 419 aa. Equivalent to Rv0389, FT len: 419 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 419 aa overlap). Probable purT, FT phosphoribosylglycinamide formyltransferase 2 (EC 2.1.2.-), FT similar to others e.g. P33221|PURT_ECOLI|B1849 FT phosphoribosylglycinamide formyltransferase 2 from FT Escherichia coli strain K-12 (391 aa), FASTA scores: opt: FT 481, E(): 1.3e-22, (40.1% identity in 379 aa overlap); etc. FT BELONGS TO THE PURK / PURT FAMILY. COFACTOR: MAGNESIUM." FT /db_xref="GOA:Q7U241" FT /db_xref="HSSP:1KJ8" FT /db_xref="InterPro:IPR011761" FT /db_xref="UniProtKB/TrEMBL:Q7U241" FT /protein_id="CAD93258.1" FT /translation="MIDGWTEGQHEPTVRHERPAAPQDVRRVMLLGSAEPSRELAIALQ FT GLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVTVTAAVSVDAL FT DAVEQADGECTELVPNARAVRCTADREGLRRLAADQLGLPTAPFWFVGSLGELQAVAVH FT AGFPLLVSPVAGVAGQGSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIE FT FLVTMIVVCSQGPNGPLIEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAARIVK FT ALGGRGVFGVELMINGDEVYFADVTVCPAGSAWVTVRSQRLSVFELQARATLGLAVDTL FT MISPGAARVINPDHTAGRAAVGAAPPADALTGALGVPESDVVIFGRGLGVALATAPEVA FT IARERAREVASRLNVPDSRE" FT CDS 127610..128032 FT /transl_table=11 FT /gene="Mb0396" FT /locus_tag="Mb0396" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0396, -, len: 140 aa. Equivalent to Rv0390, len: FT 140 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 140 aa overlap). Conserved hypothetical FT protein, equivalent to FT AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein FT from Mycobacterium leprae (147 aa), FASTA scores: opt: 778, FT E(): 0, (79.0% identity in 138 aa overlap). Also similar to FT hypothetical proteins from several Rickettsia species." FT /db_xref="HSSP:1GMX" FT /db_xref="InterPro:IPR001763" FT /db_xref="UniProtKB/TrEMBL:Q7U240" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93259.1" FT /translation="MSYAGDITPLQAWEMLSDNPRAVLVDVRCEAEWRFVGVPDLSSLG FT REVVYVEWATSDGTHNDNFLAELRDRIPADADQHERPVIFLCRSGNRSIGAAEVATEAG FT ITPAYNVLDGFEGHLDAEGHRGATGWRAVGLPWRQG" FT CDS 128029..129249 FT /transl_table=11 FT /gene="metZ" FT /locus_tag="Mb0397" FT /product="PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ FT (OSH SULFHYDRYLASE)" FT /EC_number="4.2.99.-" FT /note="Mb0397, metZ, len: 406 aa. Equivalent to Rv0391, FT len: 406 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 406 aa overlap). Probable metZ, FT O-succinylhomoserine sulfhydrylase (EC 4.2.99.-), FT equivalent, but shorter 20 aa in N-terminus, to FT AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from FT Mycobacterium leprae (426 aa). Also highly similar to FT others e.g. METZ_PSEAE|P55218 o-succinylhomoserine FT sulfhydrylase from Pseudomonas aeruginosa (403 aa), FASTA FT scores: opt: 1175, E(): 0, (47.2% identity in 392 aa FT overlap); etc. BELONGS TO THE TRANS-SULFURATION ENZYMES FT FAMILY. Could also be a cystathionine gamma-synthase (EC FT 4.2.99.9)." FT /db_xref="GOA:Q7U239" FT /db_xref="HSSP:1GC0" FT /db_xref="InterPro:IPR015422" FT /db_xref="UniProtKB/TrEMBL:Q7U239" FT /protein_id="CAD93260.1" FT /translation="MTDESSVRTPKALPDGVSQATVGVRGGMLRSGFEETAEAMYLTSG FT YVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVFTS FT LGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDDLSQWERALSVPTQAVF FT FETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGTKHID FT GQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAWVLLKGLETLAIRVQHSNASAQ FT RIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTVVTFALDCPEDVAKQRAFEVL FT DKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEDTDDLIA FT DIDRALS" FT CDS complement(129246..130658) FT /transl_table=11 FT /gene="ndhA" FT /locus_tag="Mb0398c" FT /product="PROBABLE MEMBRANE NADH DEHYDROGENASE NDHA" FT /EC_number="1.6.99.3" FT /note="Mb0398c, ndhA, len: 470 aa. Equivalent to Rv0392c, FT len: 470 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 470 aa overlap). Probable ndhA, membrane FT NADH dehydrogenase (EC 1.6.99.3), equivalent to many e.g. FT AF038423|AF038423_1 NADH dehydrogenase from Mycobacterium FT smegmatis (457 aa), FASTA scores: opt: 1991, E(): 0, (67.9% FT identity in 458 aa overlap); MLCB1788_3 NADH dehydrogenase FT from Mycobacterium leprae (466 aa), FASTA score: (62.5% FT identity in 467 aa overlap). Also similar to others from FT several organisms e.g. FT P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH FT DEHYDROGENASE from Escherichia coli (434 aa); and FT Rv0392c|ndhB from Mycobacterium tuberculosis. Has FT hydrophobic stretch in C-terminus. BELONGS TO THE NADH FT DEHYDROGENASE FAMILY." FT /db_xref="GOA:Q7U238" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:Q7U238" FT /protein_id="CAD93261.1" FT /translation="MTLSSGEPSAVGGRHRVVIIGSGFGGLNAAKALKRADVDITLISK FT TTTHLFQPLLYQVATGILSEGDIAPTTRLILRRQKNVRVLLGEVNAIDLKAQTVTSKLM FT DMTTVTPYDSLIVAAGAQQSYFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEVSTD FT HAERERRLTFVVVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAPAVLP FT PMGPKLGLKAQRRLEKMDAEVQLNAMVTAVDYKGITIKEKDGGERRIECACKVWAAGVA FT ASPLGKMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFVVGDLMFVPGVPGVAQGAIQG FT ARYATTVIKHMVKGNDDPANRKPFHYFNKGSMATISRHSAVAQVGKLEFAGYFAWLAWL FT VLHLVYLVGYRNRIAALFAWGISFMGRARGQMAITSQMIYARLVMTLMEQQAQGALAAA FT EQAEHAEQEAAG" FT CDS 130800..132125 FT /transl_table=11 FT /gene="Mb0399" FT /locus_tag="Mb0399" FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT /note="Mb0399, -, len: 441. Equivalent to Rv0393, len: 441 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 441 aa overlap). Member of Mycobacterium FT tuberculosis 13E12 repeat family of conserved proteins, FT similar to many e.g. Rv1148c, Rv1945, Rv3467, FT Rv0336|MTCY279_3 (503 aa), FASTA scores: E(): 0, (61.1% FT identity in 347 aa overlap)." FT /db_xref="GOA:Q7U237" FT /db_xref="InterPro:IPR003870" FT /db_xref="UniProtKB/TrEMBL:Q7U237" FT /protein_id="CAD93262.1" FT /translation="MAVGRCAIPRFDQAASGSAINGGQVHLSDGSTSPARQLPAPWPGD FT AGAAAEGRAGVCCRGNRLPHVSDVGVSHRFDHRPAGVGAGGCRAGAAGAGLAVDDPGQL FT AAAIDRIVAVADPDAVRQVRERARDREVSIWNSADGMGEVYAQLYATDAQALDARLNAL FT VATVCAGDPRSTDQRRADALGALAAGADRLACRCDNPDCAAEGRPVSAVVIHVVAEQAS FT VKGHGQAPAALLGGDGLIPAELVAELAKTAGLQPIPVPAGTEPGYRPSVKLAAFVRARD FT LTCRAPGCDRPATQCDLDHTIAFADGGATHAANLKCLCRLHHLLATFCGWRAQQLPDGT FT VIWTLPGNQTYVTTPGSALLFPALCTPTGDPPAPEPARADRRGQRTAMMPRRASTRTQN FT RAHCIAAERHRNHQARRIAQAAVIATETHGPPPDPDDDPPPF" FT CDS complement(132141..132860) FT /transl_table=11 FT /gene="Mb0400c" FT /locus_tag="Mb0400c" FT /product="POSSIBLE SECRETED PROTEIN" FT /note="Mb0400c, -, len: 239 aa. Equivalent to Rv0394c, len: FT 239 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 239 aa overlap). Possible secreted FT protein, sharing no homology with other proteins. Has FT hydrophobic stretch at its N-terminus." FT /db_xref="UniProtKB/TrEMBL:Q7U236" FT /protein_id="CAD93263.1" FT /translation="MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETTT FT REICESVGGADTVLSRIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDDQK FT VEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVLAAL FT IQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLILPSG FT GSAPTGDHPTPHPSTSR" FT CDS 132959..133363 FT /transl_table=11 FT /gene="Mb0401" FT /locus_tag="Mb0401" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0401, -, len: 134 aa. Equivalent to Rv0395, len: FT 134 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 134 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U235" FT /protein_id="CAD93264.1" FT /translation="MDWMPLGDYETFRHWSGKPRAWGPQESGWRAWFGGKIVDGLCEVL FT DEHLAVRRRGVPAAIGCVPWLSSEAVAETLLALSAFCVVIDKGTSFPSRLRNPDKGFPN FT VALLRLRDMAPSEHGSRCSSARGRLCLSMS" FT CDS 133369..133761 FT /transl_table=11 FT /gene="Mb0402" FT /locus_tag="Mb0402" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0402, -, len: 130 aa. Equivalent to Rv0396, len: FT 130 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 130 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U234" FT /protein_id="CAD93265.1" FT /translation="MRALGWLREDRKPLLNAKLLVLGHLALNVYDPDNGYGEEVLDFEP FT RTVWWGSANWTVRAGSHLEVGFACDDPTLVEEATAFVADVIAFSEPIDTTCAGPEPNLV FT QVEFDDAAMAEAMEEMAEPDDDGEDW" FT CDS 133835..134203 FT /transl_table=11 FT /gene="Mb0403" FT /locus_tag="Mb0403" FT /product="CONSERVED 13E12 REPEAT FAMILY PROTEIN" FT /note="Mb0403, -, len: 122 aa. Equivalent to Rv0397, len: FT 122 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 122 aa overlap). Part of 13E12 repeat FT family of conserved Mycobacterium tuberculosis proteins, FT similar to downstream Rv0393|Z84725|MTCY4D9_5 CONSERVED FT 13E12 REPEAT FAMILY PROTEIN (441 aa), FASTA scores: E(): 0, FT (87.7% identity in 122 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U233" FT /protein_id="CAD93266.1" FT /translation="MLATFWGWRAQQLPDGTVIWTLPGDQTYVTTPGSALLFPALCTPT FT GDPPRPDPARADRRGQRTAMMPRRASTRAQNRAHYIAAERHRNHQARRIAHVVTQTATT FT APETNGPPPDPDDDPPPF" FT CDS complement(134698..135339) FT /transl_table=11 FT /gene="Mb0404c" FT /locus_tag="Mb0404c" FT /product="POSSIBLE SECRETED PROTEIN" FT /note="Mb0404c, -, len: 213 aa. Equivalent to Rv0398c, len: FT 213 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 213 aa overlap). Possible secreted FT protein, sharing no homology with other proteins. Has FT potential signal sequence with hydrophobic stretch from aa FT 7-25." FT /db_xref="UniProtKB/TrEMBL:Q7U232" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93267.1" FT /translation="MGVIARVVGVAACGLSLAVLAAAPTAGAEPTGALPPMTSSGSGPV FT IGDGDAALRQRISQQLFSFGDPTVQEVDGSDAAQFITAAAAVADRDVASVFLPLQRVLG FT CQQNTAGSGAGFGARAYRRTDGQWGGAMLVVAKSTVSDVDALKACVKSGWRKATAGTPT FT SMCNNGWTYPPFADTRRGEEGYFVLLAGTASDFCSAPNANYRTTASSWPG" FT CDS complement(135346..136575) FT /transl_table=11 FT /gene="lpqK" FT /locus_tag="Mb0405c" FT /product="POSSIBLE CONSERVED LIPOPROTEIN LPQK" FT /note="Mb0405c, lpqK, len: 409 aa. Equivalent to Rv0399c, FT len: 409 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 409 aa overlap). Possible lpqK, FT conserved lipoprotein, showing some similarity to FT penicillin binding proteins and various peptidases e.g. FT DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase FT protein (406 aa), FASTA scores: opt: 348, E(): 5.6e-16, FT (29.2% identity in 301 aa overlap). Also similar to other FT Mycobacterium tuberculosis PBPs and esterases. Has possible FT N-terminal signal sequence and appropriately positioned FT prokaryotic lipoprotein lipid attachment site (PS00013)." FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q7U231" FT /protein_id="CAD93268.1" FT /translation="MPVLRRLGCSVLALGLLAGCAPPRTGPASSPTNNGAKADAVIRIV FT RDFMTQAHLKAVLVRVTVAGKEVVTRAVGDSMTGVPATTAMHFRNGAVAISYVATLLLK FT LVDEKKLRLDDKLSRWLPDFPHADRVTLGQLAQMTSGYPDYVLGNEAFDAELYANPFRQ FT WTTQELLDQISSRPLLYDPGTNWNYAHTNYLLLGLALEKAAGQDMPTLLQRKVLSPLGL FT TATANSDTPAIPEPALHAFTSERRAALKIPAGVPFYEESTFWNPSWTITHGAIQTTTIY FT DMEATAVGIGSGRLLSADSYKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLGIVISGH FT WLLQNPMFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQGNYRNQADILFRKIGAEVAP FT NDAPPMPPGR" FT CDS complement(136585..137772) FT /transl_table=11 FT /gene="fadE7" FT /locus_tag="Mb0406c" FT /product="PROBABLE ACYL-COA DEHYDROGENASE FADE7" FT /EC_number="1.3.99.-" FT /note="Mb0406c, fadE7, len: 395 aa. Equivalent to Rv0400c, FT len: 395 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 395 aa overlap). Probable fadE7, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT CAC12923.1|AL445403 putative acyl CoA dehydrogenase from FT Streptomyces coelicolor (397 aa); G624219 GLUTARYL-COA FT DEHYDROGENASE PRECURSOR (438 aa), FASTA scores: opt: 1161, FT E(): 0, (48.1% identity in 391 aa overlap); etc." FT /db_xref="GOA:Q7U230" FT /db_xref="HSSP:1JQI" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7U230" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93269.1" FT /translation="MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVA FT AWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRSLV FT SVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARRDGP FT DWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITS FT ELVLDNVRLPADAMLPGATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQ FT FGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNNTREALK FT ICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR" FT CDS 137808..138179 FT /transl_table=11 FT /gene="Mb0407" FT /locus_tag="Mb0407" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0407, -, len: 123 aa. Equivalent to Rv0401, len: FT 123 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 123 aa overlap). Probable conserved FT transmembrane protein, equivalent to AL023514|MLCB4_9 FT putative integral membrane protein from Mycobacterium FT leprae (122 aa), FASTA scores: opt: 548, E(): 4.4e-32, FT (66.9% identity in 121 aa overlap)." FT /db_xref="GOA:Q7U229" FT /db_xref="UniProtKB/TrEMBL:Q7U229" FT /protein_id="CAD93270.1" FT /translation="MRPRRALAGLAADVVAVLVFCAVGRRSHAEGLSVTGLAATAWPFL FT TGTGIGWVLARGWRRPTALAPTGVIVWLCTIVVGMVLRKVSSAGVAASFVVVASAVTAV FT LLLGWRAAVALMAPHRADG" FT CDS complement(138374..139477) FT /transl_table=11 FT /gene="mmpL1b" FT /locus_tag="Mb0408c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL1B [SECOND PART]" FT /note="Mb0408c, mmpL1b, len: 367 aa. Equivalent to 3' end FT of Rv0402c, len: 958 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 367 aa overlap). Probable FT mmpL1, conserved transmembrane transport protein (see FT citation below), member of RND superfamily, highly similar FT to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 FT hypothetical 106.2 kd membrane protein from Mycobacterium FT tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0, FT (55.4% identity in 933aa overlap); YV34_MYCLE|P54881 FT hypothetical 105.2 kd protein from Mycobacterium leprae FT (959 aa), FASTA scores: opt: 3615, E(): 0, (55.5% identity FT in 941 aa overlap); etc. Highly similar to many other FT mycobacterial MmpL proteins from Mycobacterium tuberculosis FT and M. leprae e.g. Rv0450c, Rv0676c, Rv0507, etc. BELONGS FT TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base deletion (c-*) splits mmpL1 into 2 parts, FT mmpL1a and mmpL1b." FT /db_xref="GOA:Q7U228" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/TrEMBL:Q7U228" FT /protein_id="CAD93271.1" FT /translation="MNSMDNVDKLTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQTV FT KDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAANNDDSFYLPPEAFQNPDFQRGLKL FT FLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQAASIYLAGTSSTYK FT DIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQH FT ILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKTGMIRAMAGTGRVVTIA FT GLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMTPALATLLGRWFWWPRRV FT DRLARQPQVLGPRRTTALSAERAALLQ" FT CDS complement(139474..141249) FT /transl_table=11 FT /gene="mmpL1a" FT /locus_tag="Mb0409c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL1A [FIRST PART]" FT /note="Mb0409c, mmpL1a, len: 591 aa. Equivalent to 5' end FT of Rv0402c, len: 958 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.8% identity in 568 aa overlap). Probable FT mmpL1, conserved transmembrane transport protein (see FT citation below), member of RND superfamily, highly similar FT to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 FT hypothetical 106.2 kd membrane protein from Mycobacterium FT tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0, FT (55.4% identity in 933aa overlap); YV34_MYCLE|P54881 FT hypothetical 105.2 kd protein from Mycobacterium leprae FT (959 aa), FASTA scores: opt: 3615, E(): 0, (55.5% identity FT in 941 aa overlap); etc. Highly similar to many other FT mycobacterial MmpL proteins from Mycobacterium tuberculosis FT and M. leprae e.g. Rv0450c, Rv0676c, Rv0507, etc. BELONGS FT TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base deletion (c-*) splits mmpL1 into 2 parts, FT mmpL1a and mmpL1b." FT /db_xref="GOA:Q7U227" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/TrEMBL:Q7U227" FT /protein_id="CAD93272.1" FT /translation="MRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQSV FT ARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLVTK FT LSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQRIVD FT SVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIML FT LTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQEARATG FT QNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASL FT TLAPAIIAVASRFGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKY FT QTNYNERYYIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLRNPTDMPILDRIAK FT TVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIENLQNLKDRVADLSTLTDQL FT QRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFWRPSEVSRTGS FT ATASTFPSAGRCAPC" FT CDS complement(141246..141674) FT /transl_table=11 FT /gene="mmpS1" FT /locus_tag="Mb0410c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS1" FT /note="Mb0410c, mmpS1, len: 142 aa. Equivalent to Rv0403c, FT len: 142 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 142 aa overlap). Probable mmpS1, FT conserved membrane protein (see citation below), highly FT similar to other Mycobacterial proteins e.g. FT YV33_MYCLE|P54880 hypothetical 16.9 kd protein from FT Mycobacterium leprae (154 aa), FASTA scores: opt: 458, E(): FT 1.6e-26, (46.9% identity in 143 aa overlap); FT YV33_MYCTU|Q11170 hypothetical 15 .9 kd protein from M. FT tuberculosis (147 aa), FASTA scores: opt: 362, E(): FT 1.1e-19, (42.1% identity in 140 aa overlap); etc. Also FT similar to other MmpS proteins from Mycobacterium FT tuberculosis e.g. Rv0677c, Rv0451c, etc. BELONGS TO THE FT MMPS FAMILY." FT /db_xref="GOA:P0A5K1" FT /db_xref="InterPro:IPR008693" FT /db_xref="UniProtKB/Swiss-Prot:P0A5K1" FT /protein_id="CAD93273.1" FT /translation="MFGVAKRFWIPMVIVIVVAVAAVTVSRLHSVFGSHQHAPDTGNLD FT PIIAFYPKHVLYEVFGPPGTVASINYLDADAQPHEVVNAAVPWSFTIVTTLTAVVANVV FT ARGDGASLGCRITVNEVIREERIVNAYHAHTSCLVKSA" FT CDS 141995..143752 FT /transl_table=11 FT /gene="fadD30" FT /locus_tag="Mb0411" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD30 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb0411, fadD30, len: 585 aa. Equivalent to Rv0404, FT len: 585 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 585 aa overlap). Probable fadD30, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from FT Mycobacterium bovis (582 aa); MASC_MYCLE|P54200 masc FT protein from Mycobacterium leprae (372 aa), FASTA scores: FT opt: 888, E(): 0, (44.2% identity in 342 aa overlap). Also FT similar to Y06J_MYCTU|Q10976 hypothetical 67.9 kd protein FT (626 aa), FASTA scores: opt: 1463, E(): 0, (42.4% identity FT in 568 aa overlap)." FT /db_xref="GOA:Q7U226" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U226" FT /protein_id="CAD93274.1" FT /translation="MSVISTLRDRATTTPSDEAFVFMDYDTKTGDQIDRMTWSQLYSRV FT TAVSAYLISYGRHADRRRTAAISAPQGLDYVAGFLGALCAGWAPVPLPEPLGSLRDKRT FT GLAVLDCAADVVLTTSQAETRVRATIATHGASVTTPVIALDTLDEPSGDNCDLDSQLSD FT WSSYLQYTSGSTANPRGVVLSMRNVTENVDQIIRNYFRHEGGAPRLPSSVVSWLPLYHD FT MGLMVGLFIPLFVGCPVILTSPEAFIRKPARWMQLLAKHQAPFSAAPNFAFDLAVAKTS FT EEDMAGLDLGHVNTIINGAEQVQPNTITKFLRRFRPYNLMPAAVKPSYGMAEAVVYLAT FT TKAGSPPTSTEFDADSLARGHAELSTFETERATRLIRYHSDDKEPLLRIVDPDSNIELG FT PGRIGEIWIHGKNVSTGYHNADDALNRDKFQASIREASAGTPRSPWLRTGDLGFIVGDE FT FYIVGRMKDLIIQDGVNHYPDDIETTVKEFTGGRVAAFSVSDDGVEHLVIAAEVRTEHG FT PDKVTIMDFSTIKRLVVSALSKLHGLHVTDFLLVPPGALPKTTSGKISRAACAKQYGAN FT KLQRVATFP" FT CDS 143749..145131 FT /transl_table=11 FT /gene="pks6a" FT /locus_tag="Mb0412" FT /product="PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6A FT [FIRST PART]" FT /note="Mb0412, pks6a, len: 460 aa. Equivalent to 5' end of FT Rv0405, len: 1402 aa, from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 456 aa overlap). Probable FT pks6, membrane-bound polyketide synthase, highly similar to FT others e.g. CAC29643.1|AL583917 putative polyketide FT synthase from Mycobacterium leprae (2103 aa); FT Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa), FT FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa FT overlap); etc. Contains PS00606 Beta-ketoacyl synthases FT active site, 2 x PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00012 Phosphopantetheine attachment site. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, pks6 exists as a single gene. In FT Mycobacterium bovis, a frameshift due to single base FT insertion (*-g) splits pks6 into 2 parts, pks6a and pks6b." FT /db_xref="GOA:Q7U225" FT /db_xref="InterPro:IPR018201" FT /db_xref="UniProtKB/TrEMBL:Q7U225" FT /protein_id="CAD93275.1" FT /translation="MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSID FT VLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGS FT INEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDV FT AGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDY FT VRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRS FT LSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVL FT QRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGY FT VEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAGV FT DG" FT CDS 145118..147958 FT /transl_table=11 FT /gene="pks6b" FT /locus_tag="Mb0413" FT /product="PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6B FT [SECOND PART]" FT /note="Mb0413, pks6b, len: 946 aa. Equivalent to 3' end of FT Rv0405, len: 1402 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.9% identity in 945 aa overlap). Probable FT pks6, membrane-bound polyketide synthase, highly similar to FT others e.g. CAC29643.1|AL583917 putative polyketide FT synthase from Mycobacterium leprae (2103 aa); FT Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa), FT FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa FT overlap); etc. Contains PS00606 Beta-ketoacyl synthases FT active site, 2 x PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00012 Phosphopantetheine attachment site. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, pks6 exists as a single gene. In FT Mycobacterium bovis, a frameshift due to single base FT insertion (*-g), splits pks6 into 2 parts, pks6a and FT pks6b." FT /db_xref="GOA:Q7U224" FT /db_xref="HSSP:1KEZ" FT /db_xref="InterPro:IPR001031" FT /db_xref="UniProtKB/TrEMBL:Q7U224" FT /protein_id="CAD93276.1" FT /translation="MLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRP FT RRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQ FT AGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAG FT VVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDV FT IWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCL FT PDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHD FT AVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTG FT QLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQ FT IVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWL FT APAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLG FT RDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQ FT IDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNV FT SKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALP FT QNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDT FT YLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPG FT RSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGVMSTSSEAIA FT TEIHDWISGLVRGPHP" FT CDS complement(147906..148724) FT /transl_table=11 FT /gene="Mb0414c" FT /locus_tag="Mb0414c" FT /product="BETA LACTAMASE LIKE PROTEIN" FT /note="Mb0414c, -, len: 272 aa. Equivalent to Rv0406c, len: FT 272 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 272 aa overlap). Beta-lactamase-like FT protein, equivalent to AAD38170.1|AF152397_1 FT beta-lactamase-like protein from Mycobacterium phlei (243 FT aa); AL023514|MLCB4_8 hypothetical protein from FT Mycobacterium leprae (251 aa), FASTA scores: opt: 1284, FT E(): 0, (74.9% identity in 243 aa overlap); and FT AAD38164.1|AF152394_2 beta-lactamase-like protein from FT Mycobacterium avium (247 aa), FASTA scores: opt: 1301, E(): FT 0, (74.2% identity in 244 aa overlap); etc. Also slight FT similarity to others beta-lactamases and hypothetical FT proteins e.g. P52700|BLA1_XANMA|628530|S45349 FT METALLO-BETA-LACTAMASE L1 PRECURSOR (BETA-LACTAMASE, TYPE FT II) (PENICILLINASE) from Xanthomonas maltophilia (290 aa), FT FASTA scores: (34.4% identity in 96 aa overlap)." FT /db_xref="GOA:Q7U223" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:Q7U223" FT /protein_id="CAD93277.1" FT /translation="MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLVT FT DDTGVLLIDAGYPGDRAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHSTP FT VYCHAEEVGHAKREYRENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQPLTA FT EAAAGLPGQPMAIFTPGHTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAVFSHS FT QQNSIRSLAALALLETNILAPGHGELWHGPIRKATDEALERAQKSNHVFR" FT CDS 148802..149812 FT /transl_table=11 FT /gene="fgd1" FT /locus_tag="Mb0415" FT /standard_name="fgd" FT /product="PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE FT DEHYDROGENASE FGD1" FT /EC_number="1.-.-.-" FT /note="Mb0415, fgd1, len: 336 aa. Equivalent to Rv0407, FT len: 336 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 336 aa overlap). Probable fgd1, FT F420-dependent glucose-6-phosphate dehydrogenase (EC FT 1.-.-.-), equivalent to others from Mycobacteria e.g. FT AAD38165.1|AF152394_3 from M. avium (336 aa), FASTA scores: FT opt: 2082, E(): 0, (89.9% identity in 336 aa overlap); FT AL023514|MLCB 4_7 from Mycobacterium leprae (336 aa), FASTA FT scores: opt: 2069, E(): 0, (89.0% identity in 336 aa FT overlap). Also similar to other dehydrogenases e.g. FT CAA77276.1|Y18730 F420-dependent alcohol dehydrogenase from FT Methanofollis liminatans (330 aa). Also similar to many FT proteins from Mycobacterium tuberculosis e.g. Rv0953c, FT Rv0791c, etc. Note that previously known as fgd." FT /db_xref="GOA:Q7U222" FT /db_xref="InterPro:IPR019945" FT /db_xref="UniProtKB/TrEMBL:Q7U222" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93278.1" FT /translation="MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWR FT HQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVFLG FT VGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGASIY FT DVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAADRSV FT DGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIA FT KRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRRLG" FT CDS 149805..151877 FT /transl_table=11 FT /gene="pta" FT /locus_tag="Mb0416" FT /product="PROBABLE PHOSPHATE ACETYLTRANSFERASE PTA FT (PHOSPHOTRANSACETYLASE)" FT /EC_number="2.3.1.8" FT /note="Mb0416, pta, len: 690 aa. Equivalent to Rv0408, len: FT 690 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 690 aa overlap). Probable pta, phosphate FT acetyltransferase (EC 2.3.1.8), highly similar to others FT e.g. PTA_ECOLI|P39184|11279789|JX0357|B2297 phosphate FT acetyltransferase from Escherichia coli strain K12 (713 FT aa), FASTA scores: opt: 1303, E(): 0, (38.0% identity in FT 718 aa overlap); etc. BELONGS TO THE PHOSPHATE FT ACETYLTRANSFERASE AND BUTYRYLTRANSFERASE FAMILY." FT /db_xref="GOA:Q7U221" FT /db_xref="InterPro:IPR016475" FT /db_xref="UniProtKB/TrEMBL:Q7U221" FT /protein_id="CAD93279.1" FT /translation="MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITRL FT SAERDYILELLLAHTSAGLPYERCVGVTYQQLHADRDDAIAEIVDSYHAMADECDAVVV FT VGSDYTDVTSPTELSVNARIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQRAH FT TAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVSGDVA FT LREREVMGVLAAGMTADHVLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVL FT NGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAASARGLVTATSQRKIDTALELM FT DRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRILKSAGRLL FT QRGIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQLRKAKGITV FT EHAREIMNDATYFGTMLVHNCHADGMVSGAAHTTAHTVRPALEIIKTVPGISTVSSIFL FT MCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPRVAMLSYSTGDSGKGAD FT VDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRATVLIFPDLNTG FT NNTYKAVQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITAIQAQGVHE" FT CDS 151870..153027 FT /transl_table=11 FT /gene="ackA" FT /locus_tag="Mb0417" FT /product="PROBABLE ACETATE KINASE ACKA (ACETOKINASE)" FT /EC_number="2.7.2.1" FT /note="Mb0417, ackA, len: 385 aa. Equivalent to Rv0409, FT len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 385 aa overlap). Probable ackA, acetate FT kinase (EC 2.7.2.1), highly similar to others e.g. FT ACKA_BACSU|P37877 acetate kinase from Bacillus subtilis FT (395 aa), FASTA scores: opt: 974, E(): 0, (43.5% identity FT in 393 aa overlap); etc. Contains PS01075 Acetate and FT butyrate kinases family signature 1, PS00758 ArgE / dapE / FT ACY1/ CPG2 / yscS family signature 1. BELONGS TO THE FT ACETOKINASE FAMILY." FT /db_xref="GOA:P63410" FT /db_xref="HSSP:1G99" FT /db_xref="InterPro:IPR004372" FT /db_xref="UniProtKB/Swiss-Prot:P63410" FT /protein_id="CAD93280.1" FT /translation="MSSTVLVINSGSSSLKFQLVEPVAGMSRAAGIVERIGERSSPVAD FT HAQALHRAFKMLAEDGIDLQTCGLVAVGHRVVHGGTEFHQPTLLDDTVIGKLEELSALA FT PLHNPPAVLGIKVARRLLANVAHVAVFDTAFFHDLPPAAATYAIDRDVADRWHIRRYGF FT HGTSHQYVSERAAAFLGRPLDGLNQIVLHLGNGASASAIARGRPVETSMGLTPLEGLVM FT GTRSGDLDPGVISYLWRTARMGVEDIESMLNHRSGMLGLAGERDFRRLRLVIETGDRSA FT QLAYEVFIHRLRKYLGAYLAVLGHTDVVSFTAGIGENDAAVRRDALAGLQGLGIALDQD FT RNLGPGHGARRISSDDSPIAVLVVPTNEELAIARDCLRVLGGRRA" FT CDS complement(153081..155333) FT /transl_table=11 FT /gene="pknG" FT /locus_tag="Mb0418c" FT /product="SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN FT KINASE G) (STPK G)" FT /EC_number="2.7.1.-" FT /note="Mb0418c, pknG, len: 750 aa. Equivalent to Rv0410c, FT len: 750 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 750 aa overlap). pknG, FT serine/threonine-protein kinase (EC 2.7.1.-) (see citations FT below), equivalent to FT PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 PROBABLE FT SERINE/THREONINE-PROTEIN KINASE from Mycobacterium leprae FT (767 aa). Also similar to others e.g. AB76890.1|AL159139 FT putative serine/threonine protein kinase from Streptomyces FT coelicolor (774 aa); etc. Contains PS00108 Serine/Threonine FT protein kinases active-site signature. Contains Hank's FT kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN FT KINASES." FT /db_xref="GOA:P65729" FT /db_xref="InterPro:IPR017441" FT /db_xref="UniProtKB/Swiss-Prot:P65729" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93281.1" FT /translation="MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDN FT FPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKR FT FCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLG FT WIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDR FT HGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPEN FT IMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTL FT DLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREV FT VAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLV FT DPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGD FT VAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLAL FT AATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRH FT FTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLK FT DNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF" FT CDS complement(155333..156319) FT /transl_table=11 FT /gene="glnH" FT /locus_tag="Mb0419c" FT /product="PROBABLE GLUTAMINE-BINDING LIPOPROTEIN GLNH FT (GLNBP)" FT /note="Mb0419c, glnH, len: 328 aa. Equivalent to Rv0411c, FT len: 328 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 328 aa overlap). Probable glnH, FT glutamine-binding protein, membrane-bound lipoprotein (see FT citation below), equivalent to FT AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 FT glutamine-binding protein homolog from Mycobacterium leprae FT (325 aa), FASTA scores: opt: 1747, E(): 0, (79.3% identity FT in 328 aa overlap). Also similar to others e.g. FT GLNH_BACST|P27676 glutamine-binding protein precursor from FT Bacillus stearothermophilus (262 aa), FASTA scores: opt: FT 493, E(): 7.5e-22, (37.8% identity in 193 aa overlap); etc. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site, PS01039 Bacterial extracellular FT solute-binding proteins, family 3 signature. BELONGS TO THE FT BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 3. FT Presumed attached to the membrane by a lipid anchor." FT /db_xref="GOA:Q7U220" FT /db_xref="InterPro:IPR001638" FT /db_xref="UniProtKB/TrEMBL:Q7U220" FT /protein_id="CAD93282.1" FT /translation="MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPTP FT VGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLIVGLDIGSNL FT FSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSAAERVTALQKSQVDIVVKTM FT SITCERRKLVNFSTVYLDANQRILAPRDSPITKVSDLSGKRVCVARGTTSLRRIREIAP FT PPVIVSVVNWADCLVALQQREIDAVSTDDTILAGLVEEDPYLHIVGPDMADQPYGVGIN FT LDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD" FT CDS complement(156319..157638) FT /transl_table=11 FT /gene="Mb0420c" FT /locus_tag="Mb0420c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0420c, -, len: 439 aa. Equivalent to Rv0412c, len: FT 439 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 439 aa overlap). Possible conserved FT membrane protein, equivalent to AL035159|MLCB1450_16|T44737 FT probable membrane protein from Mycobacterium leprae (403 FT aa), FASTA scores: opt: 2027, E(): 0, (80.4% identity in FT 403 aa overlap). Also some similarity with FT CAB71201.1|AL138538 putative secreted protein from FT Streptomyces coelicolor (429 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U219" FT /protein_id="CAD93283.1" FT /translation="MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLAA FT LGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAEPG FT GVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRAGNP FT VGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVVFGAF FT AHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLKTITNL FT AITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPDLQGADQ FT LLVRWRQANDRINSYISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMGQSRTQLR FT HDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR" FT CDS 157732..158385 FT /transl_table=11 FT /gene="mutT3" FT /locus_tag="Mb0421" FT /product="POSSIBLE MUTATOR PROTEIN MUTT3 FT (7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE) (8-OXO-DGTPASE) FT (DGTP PYROPHOSPHOHYDROLASE)" FT /EC_number="3.6.1.-" FT /note="Mb0421, mutT3, len: 217 aa. Equivalent to Rv0413, FT len: 217 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 217 aa overlap). Possible mutT3, FT mutator protein (EC 3.6.1.-), showing some similarity with FT e.g. MUTT_PROVU|P32090 mutator mutt protein from Proteus FT vulgaris (112 aa), FASTA scores: opt: 151, E(): 0.0008, FT (40.7% identity in 59 aa overlap). SEEMS TO BELONG TO THE FT NUDIX HYDROLASE FAMILY." FT /db_xref="GOA:Q7U218" FT /db_xref="InterPro:IPR020084" FT /db_xref="UniProtKB/TrEMBL:Q7U218" FT /protein_id="CAD93284.1" FT /translation="MPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRPD FT GTPAVLLQHRALWSHQGGTWGLPGGARDSHETPEQTAVRESSEEAGLSAERLEVRATVV FT TAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAASWQR FT LRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL" FT CDS complement(158369..159037) FT /transl_table=11 FT /gene="thiE" FT /locus_tag="Mb0422c" FT /product="PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE FT THIE (TMP PYROPHOSPHORYLASE) (TMP-PPASE) FT (THIAMINE-PHOSPHATE SYNTHASE)" FT /EC_number="2.5.1.3" FT /note="Mb0422c, thiE, len: 222 aa. Equivalent to Rv0414c, FT len: 222 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 222 aa overlap). Probable thiE, thiamin FT phosphate pyrophosphorylase (EC 2.5.1.3), equivalent to FT Q9ZBL5|AL035159|MLCB1450_17 PROBABLE THIAMINE-PHOSPHATE FT PYROPHOSPHORYLASE from Mycobacterium leprae (235 aa), FASTA FT scores: opt: 1095, E(): 0, (78.0% identity in 223 aa FT overlap). Also similar to others e.g. FT T34974|5689976|CAB52013.1|AL109663 probable thiamin FT phosphate pyrophosphorylase from Streptomyces coelicolor FT (223 aa); THIE_ECOLI|P30137 thie protein from Escherichia FT coli strain K12 (211 aa), FASTA scores: opt: 275, E(): FT 7.8e-12, (37.8% identity in 196 aa overlap); etc. BELONGS FT TO THE TMP-PPASE FAMILY." FT /db_xref="GOA:P66917" FT /db_xref="HSSP:1G4E" FT /db_xref="InterPro:IPR003733" FT /db_xref="UniProtKB/Swiss-Prot:P66917" FT /protein_id="CAD93285.1" FT /translation="MHESRLASARLYLCTDARRERGDLAQFAEAALAGGVDIIQLRDKG FT SPGELRFGPLQARDELAACEILADAAHRYGALFAVNDRADIARAAGADVLHLGQRDLPV FT NVARQILAPDTLIGRSTHDPDQVAAAAAGDADYFCVGPCWPTPTKPGRAAPGLGLVRVA FT AELGGDDKPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSALTAAN FT " FT CDS 159167..160189 FT /transl_table=11 FT /gene="thiO" FT /locus_tag="Mb0423" FT /product="POSSIBLE THIAMINE BIOSYNTHESIS OXIDOREDUCTASE FT THIO" FT /EC_number="1.-.-.-" FT /note="Mb0423, thiO, len: 340 aa. Equivalent to Rv0415, FT len: 340 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 340 aa overlap). Possible thiO, thiamine FT biosynthesis oxidoreductase (EC 1.-.-.-), equivalent to FT T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical FT protein from Mycobacterium leprae (340 aa), FASTA scores: FT opt: 1867, E(): 0, (82.0% identity in 338 aa overlap). FT Shows some similarity to other thiO proteins e.g. FT THIO_RHIET|O34292 Putative thiamine biosynthesis FT oxidoreductase from Rhizobium etli plasmid pb (327 aa) (see FT citation below); AAG31046.1|AF264948_8|THIO putative amino FT acid oxidase flavoprotein ThiO from Erwinia amylovora (349 FT aa); NP_106392.1|14025578|BAB52178.1|AP003007|THIO THIAMINE FT BIOSYNTHESIS OXIDOREDUCTASE THIO from Mesorhizobium loti FT (333 aa); etc." FT /db_xref="GOA:Q7U217" FT /db_xref="HSSP:1NG3" FT /db_xref="InterPro:IPR006076" FT /db_xref="UniProtKB/TrEMBL:Q7U217" FT /protein_id="CAD93286.1" FT /translation="MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSDERGASW FT VAGGMLAPHSEGWPGEERLLRLGLQSLRLWREGSFLDGLGPQLVTAHESLVVAVDRADV FT ADLRTVADWLSAQGHPVIWESAARDVEPLLAQGIRHGFRAPTELAVDNRALLDVLCRDC FT ERLGVRWSSQVSSLSDVDAHTVVIANGIDAPALWPGLPIRPVKGEVLRLRWRPGCMPLP FT QRVIRARVRGRQVYLVPRSDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLPALGEY FT ELAECEAGLRPMTPDNLPLVQRLDSRTLVAAGHGRSGFLLAPWTAEQIVSELVSVGAAS FT " FT CDS 160186..160392 FT /transl_table=11 FT /gene="thiS" FT /locus_tag="Mb0424" FT /product="POSSIBLE PROTEIN THIS" FT /note="Mb0424, thiS, len: 68 aa. Equivalent to Rv0416, len: FT 68 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 68 aa overlap). Possible thiS protein, FT equivalent to FT T44740|4154055|CAA22709.1|AL035159|MLCB1450.25 hypothetical FT protein from Mycobacterium leprae (74 aa), FASTA scores: FT opt: 303, E(): 2e-18, (71.6% identity in 74 aa overlap). FT Shows weak similarity with O32583|THIS_ECOLI|THIG1|B3991.1 FT THIS PROTEIN from Escherichia coli strain K12 (66 aa), FT FASTA scores: opt: 103, E(): 0.052, (30.9% identity in 68 FT aa overlap)." FT /db_xref="GOA:Q7U216" FT /db_xref="InterPro:IPR012675" FT /db_xref="UniProtKB/TrEMBL:Q7U216" FT /protein_id="CAD93287.1" FT /translation="MIVVVNEQQVEVDEQTTIAALLDSLGFGDRGIAVALNFSVLPRSD FT WATKICELRKPVRLEVVTAVQGG" FT CDS 160385..161143 FT /transl_table=11 FT /gene="thiG" FT /locus_tag="Mb0425" FT /product="PROBABLE THIAMIN BIOSYNTHESIS PROTEIN THIG FT (THIAZOLE BIOSYNTHESIS PROTEIN)" FT /note="Mb0425, thiG, len: 252 aa. Equivalent to Rv0417, FT len: 252 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 252 aa overlap). Probable thiG, thiamin FT biosynthesis protein, equivalent to FT AL035159|MLCB1450_20|T44741|THIG probable thiamin FT biosynthesis protein from Mycobacterium leprae (261 aa), FT FASTA scores: opt: 1380, E(): 0, (86.8% identity in 250 aa FT overlap). Also highly similar to others e.g. FT SCOEDB|SC6E10.03|T35490|THIG probable thiazole biosynthesis FT protein from Streptomyces coelicolor (264 aa); FT F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG thiamin FT biosynthesis protein thiG from Xylella fastidiosa (275 aa); FT P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089.1|U00006 FT THIG PROTEIN thiamin biosynthesis protein from Escherichia FT coli strain K-12 (281 aa); etc. BELONGS TO THE THIG FT FAMILY." FT /db_xref="GOA:P59948" FT /db_xref="InterPro:IPR008867" FT /db_xref="UniProtKB/Swiss-Prot:P59948" FT /protein_id="CAD93288.1" FT /translation="MAESKLVIGDRSFASRLIMGTGGATNLAVLEQALIASGTELTTVA FT IRRVDADGGTGLLDLLNRLGITPLPNTAGCRSAAEAVLTAQLAREALNTNWVKLEVIAD FT ERTLWPDAVELVRAAEQLVDDGFVVLPYTTDDPVLARRLEDTGCAAVMPLGSPIGTGLG FT IANPHNIEMIVAGARVPVVLDAGIGTASDAALAMELGCDAVLLASAVTRAADPPAMAAA FT MAAAVTAGYLARCAGRIPKRFWAQASSPAR" FT CDS 161515..163017 FT /transl_table=11 FT /gene="lpqL" FT /locus_tag="Mb0426" FT /product="PROBABLE LIPOPROTEIN AMINOPEPTIDASE LPQL" FT /EC_number="3.4.11.-" FT /note="Mb0426, lpqL, len: 500 aa. Equivalent to Rv0418, FT len: 500 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 500 aa overlap). Probable lpqL, FT lipoprotein aminopeptidase (EC 3.4.11.-), similar to others FT e.g. B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939 FT probable aminopeptidase from Pseudomonas aeruginosa (536 FT aa); P80561|APX_STRGR|SGAP|S66427 aminopeptidase (EC FT 3.4.11.-) from Streptomyces griseus (284 aa) (homology only FT with C-terminus of Rv0418); FT P37302|APE3_YEAST|1077010|A54134 aminopeptidase Y (EC FT 3.4.11.-) from Saccharomyces cerevisiae (537 aa); etc. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:Q7U215" FT /db_xref="HSSP:1CP7" FT /db_xref="InterPro:IPR003137" FT /db_xref="UniProtKB/TrEMBL:Q7U215" FT /protein_id="CAD93289.1" FT /translation="MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEFA FT VALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQTPE FT FSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDYDRL FT PVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIPVVSV FT TKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVPEGPGI FT NDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDALKGIAL FT YLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAGKTAQDTS FT FDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQKTDTLDHID FT RTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP" FT CDS 163105..164601 FT /transl_table=11 FT /gene="lpqM" FT /locus_tag="Mb0427" FT /product="POSSIBLE LIPOPROTEIN PEPTIDASE LPQM" FT /EC_number="3.4.11.-" FT /note="Mb0427, lpqM, len: 498 aa. Equivalent to Rv0419, FT len: 498 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 498 aa overlap). Possible lpqM, FT lipoprotein peptidase (EC 3.4.-.-); has potential FT N-terminal signal peptide and contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site, PS00142 Neutral FT zinc metallopeptidases, zinc-binding region signature." FT /db_xref="GOA:Q7U214" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:Q7U214" FT /protein_id="CAD93290.1" FT /translation="MHGRGRYRPLVRCVRPRRVAASVRTPIACLAAVVVIAGCTTVVDG FT RALSILNDPFRVGGLPATNGPSGARPDAPAASGTVINTNNGAIDKLSLLSVNDIEDYWM FT AVYSESLKGTFRPVGKLVSYDSNDPSSPIVCHIDTYQLVNAFFSSRCNLIAWDRGVFMA FT VAQEYFGDMSVNGVLAHEFGHALQVMANLVTRKDPTIVREQQADCFAGVYLWWVAEGKS FT TRFTLSTADGLDHVLAGIITTRDPVMEADAENDDEHGSALDRVSAFQLGFINGTPACAA FT IDEDEVERRRGDLPTTLRVDASGNPETGEVGINEETLSTLMELMGKIFSPKNPPTLSYQ FT PAGCPDAKPSPPAAYCPATNTIVVDLPALARMGKVASAAEHSLPQGDDTSLSIVMSRYA FT LAVQHERGLPMQSPWTALRTACLTGVAHRKMAVPIDLPSGQQLVLTAGDLDEAVSGLLT FT NRMVASDADGVSVPAGFTRIAAFRAGVGGDMDACYARYPG" FT CDS complement(164580..164990) FT /transl_table=11 FT /gene="Mb0428c" FT /locus_tag="Mb0428c" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /note="Mb0428c, -, len: 136 aa. Equivalent to Rv0420c, len: FT 136 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 136 aa overlap). Possible transmembrane FT protein; has potential transmembrane domains aa 53-99 and FT aa 100-122." FT /db_xref="GOA:Q7U213" FT /db_xref="UniProtKB/TrEMBL:Q7U213" FT /protein_id="CAD93291.1" FT /translation="MRLHDASAAAPESRMHIARHEEAVNRRQMFIGITGLLLAVIGLMA FT LWFPVYLDQYDAYGIKVTCGSGWRSNLTQALYADGNDNTQALVTRCDTALLVRRAWAIP FT SVALGWLLVTGFLVMWVHNDQHQGQSYPGYRA" FT CDS complement(165151..165780) FT /transl_table=11 FT /gene="Mb0429c" FT /locus_tag="Mb0429c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0429c, -, len: 209 aa. Equivalent to Rv0421c, len: FT 209 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 209 aa overlap). Conserved hypothetical FT protein, showing similarity with FT NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical FT protein from Mesorhizobium loti (214 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U212" FT /protein_id="CAD93292.1" FT /translation="MNLDQIAGVAHQPAGPPHGVVVLTHGAGGSRESTLLQQVCAEWTR FT RGWLAVRYNLPYRRRRPTGPPSGSGSGDRAGIVEAIQLCRGLAEGPLIAGGHSYGGRQT FT SMVVAAGQAPVDVLTLFSYPVHPPGKPERVRTEHLPGIAVPTVFTHGTADPFGTLAQVR FT SAAAMVSAPTEVVEITGARHDLGSKTLDVARLAVDAALRLSAGQIA" FT CDS complement(165777..166574) FT /transl_table=11 FT /gene="thiD" FT /locus_tag="Mb0430c" FT /product="PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID FT (HMP-PHOSPHATE KINASE) (HMP-P KINASE)" FT /EC_number="2.7.4.7" FT /note="Mb0430c, thiD, len: 265 aa. Equivalent to Rv0422c, FT len: 265 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 265 aa overlap). Probable thiD, FT phosphomethylpyrimidine kinase (EC 2.7.4.7), equivalent to FT AL035159|MLCB1450_21 PHOSPHOMETHYLPYRIMIDINE KINASE from FT Mycobacterium leprae (279 aa), FASTA scores: opt: 1386, FT E(): 0, (77.8% identity in 266 aa overlap). Also highly FT similar to others e.g. HIU32725_3|P44697|THID_HAEIN FT PHOSPHOMETHYLPYRIMIDINE KINASE from Haemophilus influenzae FT (269 aa), FASTA scores: opt: 605, E(): 0, (42.1% identity FT in 259 aa overlap). BELONGS TO THE THID FAMILY." FT /db_xref="GOA:P66914" FT /db_xref="HSSP:1JXH" FT /db_xref="InterPro:IPR004399" FT /db_xref="UniProtKB/Swiss-Prot:P66914" FT /protein_id="CAD93293.1" FT /translation="MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQN FT TLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLV FT VDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRAAAK FT ALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAA FT ALAHGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS" FT CDS complement(166601..168244) FT /transl_table=11 FT /gene="thiC" FT /locus_tag="Mb0431c" FT /product="PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC" FT /note="Mb0431c, thiC, len: 547 aa. Equivalent to Rv0423c, FT len: 547 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 547 aa overlap). Probable thiC, thiamin FT biosynthesis protein, equivalent to FT Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22 FT THIAMINE BIOSYNTHESIS PROTEIN from Mycobacterium leprae FT (547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity FT in 547 aa overlap). Also highly similar to others e.g. FT P45740|THIC_BACSU THIAMIN BIOSYNTHESIS PROTEIN from FT Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E(): FT 0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI FT THIC PROTEIN from Escherichia coli strain K12 (631 aa), FT FASTA scores: opt: 2141, E(): 0, (62.1% identity in 568 aa FT overlap); etc. BELONGS TO THE THIC FAMILY." FT /db_xref="GOA:P66912" FT /db_xref="InterPro:IPR002817" FT /db_xref="UniProtKB/Swiss-Prot:P66912" FT /protein_id="CAD93294.1" FT /translation="MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTG FT DHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIAARED FT MSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEVDKM FT VWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELTWEIY FT RDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYT FT NFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIE FT GPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAM FT LCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTARFEFRWND FT QFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRITQDVREYAAEHGLETEA FT DIEAVLAAGMAEKSREFAEHGNRVYLPITQ" FT CDS complement(168396..168671) FT /transl_table=11 FT /gene="Mb0432c" FT /locus_tag="Mb0432c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0432c, -, len: 91 aa. Equivalent to Rv0424c, len: FT 91 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 91 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U211" FT /protein_id="CAD93295.1" FT /translation="MAEKNTRRATSQREAVAKIREAETIVMNLPICGQVKIPRPEHLAY FT YGGLAALAALELIDWPVALVIATGHILANNHHNRVLEELGEAMEEA" FT CDS complement(168721..173340) FT /transl_table=11 FT /gene="ctpH" FT /locus_tag="Mb0433c" FT /product="POSSIBLE METAL CATION TRANSPORTING P-TYPE ATPASE FT CTPH" FT /EC_number="3.6.1.-" FT /note="Mb0433c, ctpH, len: 1539 aa. Equivalent to Rv0425c, FT len: 1539 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 1539 aa overlap). Possible ctpH, metal FT cation-transporting P-type ATPase (transmembrane protein) FT (EC 3.6.1.-), showing some similarity with FT CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative FT cation-transporting ATPase from Mycobacterium leprae (1609 FT aa). Also similar to others ATPases e.g. AE000873_1 FT CATION-TRANSPORTING P-ATPASE from Methanobacterium FT thermoautotrop (844 aa), FASTA score: (30.5% identity in FT 827 aa overlap); AB69720.1|AL137166 putative transport FT ATPase from Streptomyces coelicolor (1472 aa); etc. FT C-terminal region similar to other ATPases from FT Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative FT cation-transporting ATPase C (855 aa), FASTA scores: opt: FT 770, E(): 5.3e-32, (44.9% identity in 820 aa overlap)." FT /db_xref="GOA:Q7U210" FT /db_xref="InterPro:IPR008250" FT /db_xref="UniProtKB/TrEMBL:Q7U210" FT /protein_id="CAD93296.1" FT /translation="MPVRAVATGFRATATLTGASITAATAVSATLAKTGVGTGMKVAII FT PLRAGAKALSGELSRETLGRNCWRGERRAWIEVRGLRSGGDDELGRVVLNAIQAHPGVG FT SASLNYPLSRVVVAIDDPDTSLRELCRIVDDAEKAERHRHPDQAADQLAQSPGSLPGDG FT VLLAVRAVTVAATAAGLGLALGGRALRWPRFPLVIEAAVAAVDHQPLLRRLLEDRIGTA FT ATATVLELAMAAAHTVTLSPAALSVDLTIQALKAAECRAGARAWRRHEPQLALHADEPA FT DQPQSLWPRPARSTQPVQRSVARFALIQALSAVLVGAGTRDADMAATATLVATPKASRT FT TPEAFAAALGQGLADQHAVLPLRPESLRRLDRVDAIVIDPRVLCTDDLRVARIRGCGAD FT ELSTAWNRAQLVLTESGLRPGWHRVPGVSASGSDSAVEALFRPMHDRLASAVVAEAHRT FT GADLVSVDVDALGELRPVFDDIRPLDDGASGSLDEALARAVAELRQAGRTVAVLSSVGK FT QALSAADVALGVLPPPGAGAPPWYADVLLPDLGAAWRVLHAIPAARAARQRGNEISGGA FT SALGALLMLPGVRGLGPGPVTTGAAAGLLSGYLLARKVVDAQAPRPAPAHEWHAMSVEQ FT VRKALPSPDEQAPAKAPPSPYPARALAGGLHTAKRGAQITQAPLNALWQLTKAVRAELS FT DPLTPMLALGAMASAVLGSPVDAVMVGSVLTGNSILAASQRLRAESRLNRLLAQQIPPA FT RKVLAGADDQPRYIEVRAEELRPGDIIEVRTHEVVPADARVIEEVDVEVDESALTGESL FT SVTKQVEPTPGVDLIERRCMLYAGTTVVSGTAVAVVTAVGPDTQERRAAELVSGDLSSV FT GLQHQLSRLTNQAWPVSMTGGALVTGLGLLRRRGLRQAVASGIAVTVAAVPEGMPLVAT FT LAQQASARRLSHFGALVRIPRSVEALGRVDMVCFDKTGTLSENRLRVAQVRPVAGHSRE FT EVLRCAAHAAPASNGPQVHATDVAIVQAAAAAAASGTDGAEPGAAEPAAHLPFRSGRSF FT SASVSGTELTVKGAPEVVLAACEGIGSSMDDAVAELAANGLRVIAVAHRQLTAQQAQSV FT VDDPDEIARLCRDELSLVGFLGLSDTPRAQAAALLADLHEHDLDIRLITGDHPITAAAI FT AEELGMQVSPEQVISGAEWDALSRKDQERAVAERVIFARMTPENKVQIVQTLEHSGRVC FT AMVGDGSNDAAAIRAATVGIGVVAHGSDPARVAADLVLVDGRIESLLPAILEGRQLWQR FT VQAAVSVLLGGNAGEVAFAIIGSAITGTSPLNTRQLLLVNMLTDALPAAALAVSKPSDP FT VTPATRGPDQRELWRAVGIRGATTAAAATVAWVMAGFTGLPRRASTVALVALVAAQLGQ FT TLVDSHAWLVVLTALGSLAALATLISIPVVSQLLGCTPLDPLGWAQATAAATAATVAVA FT VLNRVLTGRDKSGQPNPQPPETDALSRDASPGAPPGPRRRRRATARRKAPVKAPSATRQ FT TTKPKGPPAHRSSSTYPRR" FT CDS complement(173392..173835) FT /transl_table=11 FT /gene="Mb0434c" FT /locus_tag="Mb0434c" FT /product="POSSIBLE TRANSMEMBRANE PROTEIN" FT /note="Mb0434c, -, len: 147 aa. Equivalent to Rv0426c, len: FT 147 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 147 aa overlap). Possible transmembrane FT protein; has potential transmembrane domains aa 19-41, and FT aa 61-83." FT /db_xref="GOA:Q7U209" FT /db_xref="UniProtKB/TrEMBL:Q7U209" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93297.1" FT /translation="MSVVGGTVRTVGRTVSGAATATTAAAGAVGGAAVSGIVGGVTGAA FT KGIQKGLSSGSKSTAAAALAIGAIGVAGLVDWPILLAVGGGALLLRKLNRTPEVAAPPV FT KAKLAPVPDKPAAAKEAPAKASKTTARKTSGRRAGTAELRSTN" FT CDS complement(174036..174911) FT /transl_table=11 FT /gene="xthA" FT /locus_tag="Mb0435c" FT /product="PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA FT (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI)" FT /EC_number="3.1.11.2" FT /note="Mb0435c, xthA, len: 291 aa. Equivalent to Rv0427c, FT len: 291 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 291 aa overlap). Probable xthA FT (alternate gene name: xth), exodeoxyribonuclease III FT protein (EC 3.1.11.2), similar to others e.g. FT EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia FT Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): FT 1.2e-17, (29.3% identity in 270 aa overlap); etc. BELONGS FT TO THE AP/EXOA FAMILY OF DNA REPAIR ENZYMES." FT /db_xref="GOA:Q7U208" FT /db_xref="HSSP:1E9N" FT /db_xref="InterPro:IPR005135" FT /db_xref="UniProtKB/TrEMBL:Q7U208" FT /protein_id="CAD93298.1" FT /translation="MPDGTIDGGHPQRPASPRLRSPLLRLATWNVNSIRTRLDRVLDWL FT GRADVDVLAMQETKCPDGQFPALPLFELGYDVAHVGFDQWNGVAIASRVGLDDVRVGFD FT GQPSWSGKPEVAATTEARALGATCGGIRVWSLYVPNGRALDDPHYTYKLDWLAALRDTA FT EGWLRDDPAAPIALMGDWNIAPTDDDVWSTEFFAGCTHVSEPERKAFNAIVDAQFTDVV FT RPFTPGPGVYTYWDYTQLRFPKKQGMRIDFILGSPALAARVMDAQIVREERKGKAPSDH FT APVLVDLHAG" FT CDS complement(174914..175822) FT /transl_table=11 FT /gene="Mb0436c" FT /locus_tag="Mb0436c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0436c, -, len: 302 aa. Equivalent to Rv0428c, len: FT 302 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 302 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U207" FT /protein_id="CAD93299.1" FT /translation="MVSWPGLGTRVTVRYRRPAGSMPPLTDAVGRLLAVDPTVRVQTKT FT GTIVEFSPVDVVALRVLTDAPVRTAAIRALEHAAAAAWPGVERTWLDGWLLRAGHGAVL FT AANSAVPLDISAHTNTITEISAWYASRDLQPWLAVPDRLLPLPAGLAGERREQVLVRDV FT STGEPDRSVTLLDHPDDTWLRLYHQRLPLDMATPVIDGELAFGSYLGVAVARAAVTDAP FT DGTRWVGLSAMRAADEQSATGSAGRQLWEALLGWGAGRGATRGYVRVHDTATSVLAESL FT GFRLHHHCRYLPAQSVGWDTF" FT CDS complement(175822..176415) FT /transl_table=11 FT /gene="def" FT /locus_tag="Mb0437c" FT /product="PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) FT (FORMYLMETHIONINE DEFORMYLASE)" FT /EC_number="3.5.1.31" FT /note="Mb0437c, def, len: 197 aa. Equivalent to Rv0429c, FT len: 197 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 197 aa overlap). Probable def, FT polypeptide deformylase (EC 3.5.1.31), equivalent to FT CAC30884.1|AL583923 polypeptide deformylase from FT Mycobacterium leprae (197 aa). Also similar to others e.g. FT DEF_ECOLI|P27251|95874|S23107 polypeptide deformylase from FT Escherichia coli (169 aa), FASTA scores: opt: 179, E(): FT 1.8e-05, (34.6% identity in 162 aa overlap); etc. BELONGS FT TO THE POLYPEPTIDE DEFORMYLASE FAMILY. COFACTOR: BINDS 1 FT ZINC ION." FT /db_xref="GOA:Q7U206" FT /db_xref="InterPro:IPR000181" FT /db_xref="UniProtKB/Swiss-Prot:Q7U206" FT /protein_id="CAD93300.1" FT /translation="MTVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTMD FT AANGVGLAANQIGCSLRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTDDE FT GCLSVPGESFPTGRAKWARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLDRLI FT GRYARNAKRAVKSHGWGVPGLSWLPGEDPDPFGH" FT CDS 176752..177060 FT /transl_table=11 FT /gene="Mb0438" FT /locus_tag="Mb0438" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0438, -, len: 102 aa. Equivalent to Rv0430, len: FT 102 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 102 aa overlap). Conserved hypothetical FT protein, equivalent to AC30882.1|AL583923 conserved FT hypothetical protein from Mycobacterium leprae (102 aa). FT Also highly similar to CAB93047.1|SCD95A.20|AL357432 FT hypothetical protein from Streptomyces coelicolor (84 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U205" FT /protein_id="CAD93301.1" FT /translation="MDSAMARAIRSGDDAEVADGLTRREHDILAFERQWWKFAGVKEEA FT IKELFSMSATRYYQVLNALVDRPEALAADPMLVKRLRRLRASRQKARAARRLGFEVT" FT CDS 177092..177586 FT /transl_table=11 FT /gene="Mb0439" FT /locus_tag="Mb0439" FT /product="PUTATIVE TUBERCULIN RELATED PEPTIDE" FT /note="Mb0439, -, len: 164 aa. Equivalent to Rv0431, len: FT 164 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.8% identity in 164 aa overlap). Putative tuberculin FT related peptide; almost identical to D00815|MSGAT103_1 FT AT103 from Mycobacterium tuberculosis (172 aa), FASTA FT score: (99.4% identity in 163 aa overlap). Highly similar FT to to CAC30881.1|AL583923 tuberculin related peptide FT (AT103) from Mycobacterium leprae (167 aa). Some similarity FT to G550415|HRPC (282 aa), FASTA scores: opt: 120, E(): FT 0.36, (33.3% identity in 111 aa overlap). Potential FT transmembrane domain at aa 19-37." FT /db_xref="UniProtKB/TrEMBL:Q7U204" FT /protein_id="CAD93302.1" FT /translation="MLVTVGSMNERVPDSSGLPLRAMVMVLLFLGVVFLLLGWQALGSS FT PNSEDDSSAISTMTTTTAAPTSTSVKPAAPRAEVRVYNISGAEGAAARTADRLKAAGFT FT VTDVGNLSLPDVAATTVYYTEVEGERATADAVGRTLGAAVELRLPELSDQPPGVIVVVT FT G" FT CDS 177619..178341 FT /transl_table=11 FT /gene="sodC" FT /locus_tag="Mb0440" FT /product="PROBABLE PERIPLASMIC SUPEROXIDE DISMUTASE [CU-ZN] FT SODC" FT /EC_number="1.15.1.1" FT /note="Mb0440, sodC, len: 240 aa. Equivalent to Rv0432, FT len: 240 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 240 aa overlap). Probable sodC, FT periplasmic superoxide dismutase [Cu-Zn] (EC 1.15.1.1), FT equivalent to CAC30880.1|AL583923 superoxide dismutase FT precursor (Cu-Zn) from Mycobacterium leprae (240 aa); and FT AAK20038.1|AF326234_1 copper zinc superoxide dismutase from FT Mycobacterium avium subsp. paratuberculosis (226 aa). Also FT similar to others e.g. SODC_PHOLE|P00446 superoxide FT dismutase precursor (cu-zn) from Photobacterium leiognathi FT (173 aa), FASTA scores: opt: 214, E(): 5.2 e-06, (36.5% FT identity in 181 aa overlap). Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site. BELONGS TO THE FT CU-ZN SUPEROXIDE DISMUTASE FAMILY. Possibly localized in FT periplasm, membrane-bound." FT /db_xref="GOA:P0A609" FT /db_xref="HSSP:1OZU" FT /db_xref="InterPro:IPR001424" FT /db_xref="UniProtKB/Swiss-Prot:P0A609" FT /protein_id="CAD93303.1" FT /translation="MPKPADHRNHAAVSTSVLSALFLGAGAALLSACSSPQHASTVPGT FT TPSIWTGSPAPSGLSGHDEESPGAQSLTSTLTAPDGTKVATAKFEFANGYATVTIATTG FT VGKLTPGFHGLHIHQVGKCEPNSVAPTGGAPGNFLSAGGHYHVPGHTGTPASGDLASLQ FT VRGDGSAMLVTTTDAFTMDDLLSGAKTAIIIHAGADNFANIPPERYVQVNGTPGPDETT FT LTTGDAGKRVACGVIGSG" FT CDS 178343..179473 FT /transl_table=11 FT /gene="Mb0441" FT /locus_tag="Mb0441" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0441, -, len: 376 aa. Equivalent to Rv0433, len: FT 376 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 376 aa overlap). Conserved hypothetical FT protein, similar to other hypothetical proteins e.g. FT P77213|YBDK_ECOLI hypothetical 41.7 KD protein from FT Escherichia coli strain K12 (372 aa), FASTA scores: opt: FT 555, E(): 2e-30, (28.2% identity in 365 aa overlap)." FT /db_xref="GOA:P64694" FT /db_xref="InterPro:IPR011793" FT /db_xref="UniProtKB/Swiss-Prot:P64694" FT /protein_id="CAD93304.1" FT /translation="MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVIA FT EIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGTHP FT FARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNYYPH FT LLALSASSPWWGGEDTGYASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDH FT MDEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMP FT PWHVQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCADELAAVS FT DIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI" FT CDS 179533..180186 FT /transl_table=11 FT /gene="Mb0442" FT /locus_tag="Mb0442" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0442, -, len: 217 aa. Equivalent to Rv0434, len: FT 217 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 217 aa overlap). Conserved hypothetical FT protein, similar to AE002052_2 from Deinococcus radiodurans FT (213 aa), FASTA scores: opt: 258, E(): 4e-10, (31.9% FT identity in 213 aa overlap); SYCSLRB_122|Q55701 FT hypothetical 24.5 kDa protein from Synechocystis (214 aa), FT FASTA scores: opt: 156, E(): 0.00041, (28.4% identity in FT 204 aa overlap); MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent FT protease la 2 from Myxococcus xanthus (826 aa), FASTA FT scores: opt: 160, E(): 0.00068, (28.4% identity in 197 aa FT overlap); etc." FT /db_xref="GOA:Q7U203" FT /db_xref="InterPro:IPR003111" FT /db_xref="UniProtKB/TrEMBL:Q7U203" FT /protein_id="CAD93305.1" FT /translation="MADFAPVELAMFPLESAPLPDEDLPLHIFEPRYAALVRDCMDTAD FT PRFGVVLISRGREVGGGDTRCDVGTLARITECADAGSGRYMLRCRVGERIRVCDWLPDD FT PYPRAKVRFWPDQPGHPVTAAQLLEVEDRVVALFERIAAARGVRLPAREVVLGYPVVDP FT ADTGQRLYALACRVPMGPADRYAVLAAPSAADRLVRLGDALDSVAAMVEFELST" FT CDS complement(180366..182552) FT /transl_table=11 FT /gene="Mb0443c" FT /locus_tag="Mb0443c" FT /product="PUTATIVE CONSERVED ATPASE" FT /EC_number="3.6.1.-" FT /note="Mb0443c, -, len: 728 aa. Equivalent to Rv0435c, len: FT 728 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 728 aa overlap). Putative conserved FT ATPase (EC 3.6.1.-), similar to others e.g. FT SAV_SULAC|Q07590 sav protein involved in cell division from FT sulfolobus acidocaldarius (780 aa), FASTA scores: opt: 897, FT E(): 0, (34.5% identity in 693 aa overlap); FT NP_148637.1|7435761|B72479 transitional endoplasmic FT reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also FT similar to Rv3610c and Rv2115c from Mycobacterium FT tuberculosis. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), and PS00674 AAA-protein family signature." FT /db_xref="GOA:Q7U202" FT /db_xref="HSSP:1R7R" FT /db_xref="InterPro:IPR003960" FT /db_xref="UniProtKB/TrEMBL:Q7U202" FT /protein_id="CAD93306.1" FT /translation="MTHPDPARQLTLTARLNTSAVDSRRGVVRLHPNAIAALGIREWDA FT VSLTGSRTTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTVYGARSVTLS FT GSTLATQSVPPVTLRQALLGKVMTVGDAVSLLPRDLGPGTSTSAASRALAAAVGISWTS FT ELLTVTGVDPDGPVSVQPNSLVTWGAGVPAAMGTSTAGQVSISSPEIQIEELKGAQPQA FT AKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCDGRRLVTLDGPEI FT GALAAGDRVKAVASAVQAVRHEGGVLLITDADALLPAAAEPVASLILSELRTAVATAGV FT VLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTGDLNLDEIAS FT RTPGFVVADLAALVREAALRAASRASADGRPPMLHQDDLLGALTVIRPLSRSASDEVTV FT GDVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRA FT LASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQS FT FDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFVEPPDA FT AARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAANVT FT AADLATARETVRASLDPLQVASLRKFGTKGDLRS" FT CDS complement(182549..183409) FT /transl_table=11 FT /gene="pssA" FT /locus_tag="Mb0444c" FT /product="PROBABLE CDP-DIACYLGLYCEROL--SERINE FT O-PHOSPHATIDYLTRANSFERASE PSSA (PS SYNTHASE) FT (PHOSPHATIDYLSERINE SYNTHASE)" FT /EC_number="2.7.8.8" FT /note="Mb0444c, pssA, len: 286 aa. Equivalent to Rv0436c, FT len: 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 286 aa overlap). Probable pssA, PS FT synthase (CDP-diacylglycerol--serine FT O-phosphatidyltransferase) (EC 2.7.8.8) (see citation FT below), integral membrane protein, equivalent to FT AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 FT aa), FASTA scores: opt: 1506, E(): 0, (77.9% identity in FT 285 aa overlap). Also highly similar to others e.g. FT NP_108059.1|14027250|BAB54204.1|AP003012 phosphatidylserine FT synthase from Mesorhizobium loti (248 aa); PSS_BACSU|P39823 FT cdp-diacylglycerol--serine o-phosphatidyltransferase from FT Bacillus subtilis (177 aa), FASTA scores: opt: 277, E(): FT 9.9e-12, (33.3% identity in 183 aa overlap); etc. Contains FT PS00379 CDP-alcohol phosphatidyltransferases signature. FT BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FT FAMILY." FT /db_xref="GOA:P59949" FT /db_xref="InterPro:IPR000462" FT /db_xref="UniProtKB/Swiss-Prot:P59949" FT /protein_id="CAD93307.1" FT /translation="MIGKPRGRRGVNLQILPSAMTVLSICAGLTAIKFALEHQPKAAMA FT LIAAAAILDGLDGRVARILDAQSRMGAEIDSLADAVNFGVTPALVLYVSMLSKWPVGWV FT VVLLYAVCVVLRLARYNALQDDGTQPAYAHEFFVGMPAPAGAVSMIGLLALKMQFGEGW FT WTSVWFLSFWVTGTSILLVSGIPMKKMHAVSVPPNYAAALLAVLAICAAAAVLAPYLLI FT WVIIIAYMCHIPFAVRSQRWLAQHPEVWDDKPKQRRAVRRASRRAHPYRPSMARLGLRK FT PGRRL" FT CDS complement(183406..184101) FT /transl_table=11 FT /gene="psd" FT /locus_tag="Mb0445c" FT /product="POSSIBLE PHOSPHATIDYLSERINE DECARBOXYLASE PSD (PS FT DECARBOXYLASE)" FT /EC_number="4.1.1.65" FT /note="Mb0445c, psd, len: 231 aa. Equivalent to Rv0437c, FT len: 231 aa (start uncertain), from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 231 aa FT overlap). Possible psd, phosphatidylserine decarboxylase FT (EC 4.1.1.65), equivalent to CAC29819.1|AL583918 conserved FT hypothetical protein from Mycobacterium leprae (243 aa); FT and highly similar to FT MLCB1450.11|T44729|4154044|CAA22695.1|AL035159 hypothetical FT protein from Mycobacterium leprae (202 aa), FASTA score: FT (74.6% identity in 197 aa overlap). Also similar to other FT phosphatidylserine decarboxylases e.g. FT NP_108058.1|14027249|BAB54203.1|AP003012 phosphatidylserine FT decarboxylase from Mesorhizobium loti (232 aa); FT AAK86872|g15156090|AGR_C_1963 phosphatidylserine FT decarboxylase from Agrobacterium tumefaciens (244 aa); FT AAG12422.1|AY005137|Psd phosphatidylserine decarboxylase FT from Chlorobium tepidum (216 aa); etc." FT /db_xref="GOA:P67548" FT /db_xref="InterPro:IPR004428" FT /db_xref="UniProtKB/Swiss-Prot:P67548" FT /protein_id="CAD93308.1" FT /translation="MARRPRPDGPQHLLALVRSAVPPVHPAGRPFIAAGLAIAAVGHRY FT RWLRGTGLLAAAACAGFFRHPQRVPPTRPAAIVAPADGVICAIDSAAPPAELSMGDTPL FT PRVSIFLSILDAHVQRAPVSGEVIAVQHRPGRFGSADLPEASDDNERTSVRIRMPNGAE FT VVAVQIAGLVARRIVCDAHVGDKLAIGDTYGLIRFGSRLDTYLPAGAEPIVNVGQRAVA FT GETVLAECR" FT CDS complement(184162..185379) FT /transl_table=11 FT /gene="moeA2" FT /locus_tag="Mb0446c" FT /product="PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN FT MOEA2" FT /note="Mb0446c, moeA2, len: 405 aa. Equivalent to Rv0438c, FT len: 405 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 405 aa overlap). Probable moeA2, FT molybdenum cofactor biosynthesis protein, highly similar to FT many e.g. Y10817|ANY10817_2 from A. nicotinovorans (429 FT aa), FASTA scores: opt: 786, E(): 0, (39.2% identity in 398 FT aa overlap); etc. Also similar to FT MOEA1|Rv0994|MTCI237.08|O05577 PROBABLE MOLYBDOPTERIN FT BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (426 FT aa), FASTA scores: opt: 667, E(): 2e-32, (36.5% identity in FT 425 aa overlap). Note that previously known as moeA3." FT /db_xref="GOA:Q7U201" FT /db_xref="HSSP:1G8L" FT /db_xref="InterPro:IPR005111" FT /db_xref="UniProtKB/TrEMBL:Q7U201" FT /protein_id="CAD93309.1" FT /translation="MRSVQEHQRVVAEMIRACRPITVPLTQAQGLVLGGDVVAPLSLPV FT FDNSAMDGYAVRAEDTSGATPQNPVMLPVAEDIPAGRADMLTLQPVTAHRIMTGAPVPT FT GATAIVPVEATDGGVDSVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLGLAA FT ALGLAELPVLPRQRVLVISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAVVATA FT TAGDDVAQFGAILDRYAVDADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEFVKVA FT MQPGMPQGVGRVAGTPIVTLPGNPVSALVSFEVFIRPPLRMAMGLPDPYRPHRSAVLTA FT SLTSPRGKRQFRRAILDHQAGTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQL FT QVWDLT" FT CDS complement(185398..186333) FT /transl_table=11 FT /gene="Mb0447c" FT /locus_tag="Mb0447c" FT /product="PUTATIVE DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0447c, -, len: 311 aa. Equivalent to Rv0439c, len: FT 311 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 311 aa overlap). Probable FT dehydrogenase/reductase (EC 1.-.-.-), equivalent to FT AL035159|MLCB1450_6|T44727 probable oxidoreductase from FT Mycobacterium leprae (304 aa), FASTA scores: opt: 1360, FT E(): 0, (69.2% identity in 302 aa overlap). Also highly FT similar to various oxidoreductases, generally FT dehydrogenases/reductases e.g. FT PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 FT probable short chain dehydrogenase from Pseudomonas FT aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE FT OXIDOREDUCTASE from Streptomyces antibioticus (298 aa), FT FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in FT 298 aa overlap); etc." FT /db_xref="GOA:Q7U200" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U200" FT /protein_id="CAD93310.1" FT /translation="MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRG FT AHVVLAVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPRIDVL FT INNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGSRVVTVSSQGHRIH FT AAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRRLGEAGKSTIAVAAHPGGSNTEL FT TRNLPRLIRPVATVLGPLLFQSPEMGALPTLRAATDPTTQGGQYYGPDGFGEQRGHPKV FT VQSSAQSHDKDLQRRLWTVSEELTGVSFGV" FT CDS 186627..188249 FT /transl_table=11 FT /gene="groEL2" FT /locus_tag="Mb0448" FT /standard_name="groL2; groEL-2; hsp65; hsp60" FT /product="60 KDA CHAPERONIN 2 GROEL2 (PROTEIN CPN60-2) FT (GROEL PROTEIN 2) (65 KDA ANTIGEN) (HEAT SHOCK PROTEIN 65) FT (CELL WALL PROTEIN A) (ANTIGEN A)" FT /note="Mb0448, groEL2, len: 540 aa. Equivalent to Rv0440, FT len: 540 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 540 aa overlap). groEL2 (alternate gene FT names: groL2, groEL-2, hsp65, hsp60), 60 kDa chaperonin 2 FT (see first citation below). PURIFIED 65 kDa ANTIGEN CAN FT ELICIT A STRONG DELAYED-TYPE HYPERSENSITIVITY REACTION IN FT EXPERIMENTAL ANIMALS INFECTED WITH M. TUBERCULOSIS. THIS FT PROTEIN IS ONE OF THE MAJOR IMMUNOREACTIVE PROTEINS OF THE FT MYCOBACTERIA. THIS ANTIGEN CONTAINS EPITOPES THAT ARE FT COMMON TO VARIOUS SPECIES OF MYCOBACTERIA. Contains PS00296 FT Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN FT (HSP60) FAMILY." FT /db_xref="GOA:P0A521" FT /db_xref="HSSP:1IOK" FT /db_xref="InterPro:IPR002423" FT /db_xref="UniProtKB/Swiss-Prot:P0A521" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93311.1" FT /translation="MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGA FT PTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLR FT NVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEA FT MDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVS FT SKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGD FT RRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAI FT AGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVR FT NAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLE FT PGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAV FT VADKPEKEKASVPGGGDMGGMDF" FT CDS complement(188315..188743) FT /transl_table=11 FT /gene="Mb0449c" FT /locus_tag="Mb0449c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0449c, -, len: 142 aa. Equivalent to Rv0441c, len: FT 142 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 142 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR020145" FT /db_xref="UniProtKB/Swiss-Prot:P0A5C8" FT /protein_id="CAD93312.1" FT /translation="MGAKKVDLKRLAAALPDYPFAYLITVDDGHRVHTVAVEPVLRELP FT DGPDGPRAVVDVGLIGGRTRQNLAHRSEVTLLWPPSDPSGYSLIVDGRAQASDAGPDDD FT TARCGVVPIRALLHRDAAPDSPTAAKGCLHDCVVFSVP" FT CDS complement(188770..190209) FT /transl_table=11 FT /gene="PPE10" FT /locus_tag="Mb0450c" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0450c, PPE10, len: 479 aa. Equivalent to Rv0442c, FT len: 487 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 479 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family, nearly identical to FT hypothetical protein from Mycobacterium tuberculosis FT (strain Erdman) and to AN5S46909_1 protein fragment from FT Mycobacterium bovis (302 aa); P42611|YHS6_MYCTU FT HYPOTHETICAL 50.6 KD PROTEIN (517 aa), FASTA scores: opt: FT 3144, E(): 0, (98.4 identity in 492 aa overlap); and FT S46909|S46909_1 (302 aa), FASTA scores: opt: 1897, E(): 0, FT (98.0% identity in 302 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, FT truncation at the 5' start due to a single base transition FT (g-a), leads to a shorter product compared to its homolog FT in Mycobacterium tuberculosis strain H37Rv (479 aa versus FT 487 aa)." FT /db_xref="InterPro:IPR002989" FT /db_xref="UniProtKB/TrEMBL:Q7U1Z9" FT /protein_id="CAD93313.1" FT /translation="MPPEINSALMFAGPGSGPLIAAATAWGELAEELLASIASLGSVTS FT ELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAAAQAMAIATAFEAALAATVQPAV FT VAANRGLMQLLAATNWFGQNAPALMDVEAAYEQMWALDVAAMAGYHFDASAAVAQLAPW FT QQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIGSGNTGTGNIGSGNTGSGNL FT GLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSGTGNVGLFNSGS FT GNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAALGSAAGSEAALVSSA FT GYATGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPVAAPASAPVGGLDSGN FT PNPGSGSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVREPSTPGSGIPKSNFY FT PSPDRESAYASPRIGQPVGSE" FT CDS 190415..190930 FT /transl_table=11 FT /gene="Mb0451" FT /locus_tag="Mb0451" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0451, -, len: 171 aa. Equivalent to Rv0443, len: FT 171 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 171 aa overlap). Conserved hypothetical FT protein, highly similar to AL049863|SC5H1_23|T35339 FT hypothetical protein from Streptomyces coelicolor (171 aa), FT FASTA scores: opt: 561, E(): 2.3e-32, (49.7% identity in FT 165 aa overlap); and CAC42482.1|AJ318385 hypothetical FT protein from Amycolatopsis mediterranei (163 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U1Z8" FT /protein_id="CAD93314.1" FT /translation="MASTDAAAQELLRDAFTRLIEHVDELTDGLTDQLACYRPTPSANS FT IAWLLWHSARVQDIQVAHVAGVEEVWTRDGWVDRFGLDLPRHDTGYGHRPEDVAKVRAP FT ADLLSGYYHAVHKLTLEYIAGMTADELSRVVDTSWNPPVTVSARLVSIVDDCAQHLGQA FT AYLRGIAR" FT CDS complement(191110..191808) FT /transl_table=11 FT /gene="Mb0452c" FT /locus_tag="Mb0452c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0452c, -, len: 232 aa. Equivalent to Rv0444c, len: FT 232 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.1% identity in 232 aa overlap). Conserved hypothetical FT protein; C-terminus similar to P12752|Y24K_STRGR FT HYPOTHETICAL 24.7 KD PROTEIN from Streptomyces griseus (238 FT aa), FASTA scores: opt: 207, E(): 2.2e-05, (32.9% identity FT in 158 aa overlap)." FT /db_xref="GOA:Q7U1Z7" FT /db_xref="InterPro:IPR018764" FT /db_xref="UniProtKB/Swiss-Prot:Q7U1Z7" FT /protein_id="CAD93315.1" FT /translation="MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFN FT DEVRAVRETMAVVSAATTAEPPAHLRTAILDATKPEVRRQSRWRTAAFASAAAIAVGLG FT AFDLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNVAPP FT SRGTVYQMWLLGGAKGPRSAETMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPT FT GTILAELPLG" FT CDS complement(191852..192415) FT /transl_table=11 FT /gene="sigK" FT /locus_tag="Mb0453c" FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGK" FT /note="Mb0453c, sigK, len: 187 aa. Equivalent to Rv0445c, FT len: 187 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 187 aa overlap). Probable sigK, FT alternative RNA polymerase sigma factor (see citation FT below), highly similar to others e.g. FT 5531433|CAB50938.1|AL096849|T36745 probable RNA polymerase FT sigma factor from Streptomyces coelicolor (185 aa); FT NP_105607.1|14024791|BAB51393.1|AP003005 RNA polymerase FT sigma factor from Mesorhizobium loti (179 aa); FT 1654108|AAB17906.1|U11283|A58883 probable transcription FT initiation factor sigma E from Rhodobacter phaeroides (168 FT aa), FASTA scores: opt: 299, E(): 2e-14, (32.7% identity in FT 168 aa overlap); Q45585|SIGW_BACSU RNA POLYMERASE SIGMA FT FACTOR SIGW from Bacillus subtilis (187 aa), FASTA scores: FT opt: 213, E(): 2.9e-08, (26.8% identity in 179 aa overlap); FT etc." FT /db_xref="GOA:Q7U1Z6" FT /db_xref="InterPro:IPR007630" FT /db_xref="UniProtKB/Swiss-Prot:Q7U1Z6" FT /protein_id="CAD93316.1" FT /translation="MTGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVYGLVMRVL FT RDTGYSEETTQEIYLEVWRNASEFDSAKGSALAWLLTMAHRRAVDRVRCEQAGNQREVR FT YGAANVDPASDVVADLAIAGDERRRVTECLKALTDTQRQCIELAYYGGLTYVEVSRRLA FT ANLSTIKSRMRDALRSLRNCLDVS" FT CDS complement(192464..193234) FT /transl_table=11 FT /gene="Mb0454c" FT /locus_tag="Mb0454c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0454c, -, len: 256 aa. Equivalent to Rv0446c, len: FT 256 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 256 aa overlap). Possible conserved FT transmembrane protein, similar at N-terminus to FT U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 FT aa), FASTA scores: opt: 175, E(): 2.5e-05, (62.5% identity FT in 40 aa overlap); and at C-terminus to AL021529|SC10A5_3 FT from Streptomyces coelicolor (226 aa), FASTA scores: opt: FT 207, E(): 9.8e-07, (34.2% identity in 114 aa overlap). Also FT similar to others hypothetical proteins e.g. FT AAK04680.1|AE006291_14|AE006291) HYPOTHETICAL PROTEIN from FT Lactococcus lactis subsp. lactis (257 aa)." FT /db_xref="GOA:Q7U1Z5" FT /db_xref="InterPro:IPR001104" FT /db_xref="UniProtKB/TrEMBL:Q7U1Z5" FT /protein_id="CAD93317.1" FT /translation="MVTSVSALAVAVVHSVAFAIGRRIGRYNVVDVVWGLGFVAVAVAA FT ATLGHGDPVRRWLLLALVSTWGLRLSWHMYRKTAGQGEDPRYADLLRGATPVQALRKVF FT GLQGLLTLFVSFPLQLSAVTGPTPKPLLAVGGVGLAVWLVGITFEAVGDWQLWVFKSDP FT ANRGVIMDRGLWAWTRHPNYFGDACVWWGLWLITINDWAPLATVGSPLLMTYLLVDVSG FT ARLTERYLKGRPGFAEYQRRTAYFVPRPPRSARR" FT CDS complement(193243..194526) FT /transl_table=11 FT /gene="ufaA1" FT /locus_tag="Mb0455c" FT /product="PUTATIVE CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID FT SYNTHASE UFAA1 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA FT SYNTHASE)" FT /EC_number="2.1.1.79" FT /note="Mb0455c, ufaA1, len: 427 aa. Equivalent to Rv0447c, FT len: 427 aa (start uncertain), from Mycobacterium FT tuberculosis strain H37Rv, (100.0% identity in 427 aa FT overlap). Probable ufaA1, FT cyclopropane-fatty-acyl-phospholipid synthase (EC FT 2.1.1.79), similar to others e.g. FT NP_102178.1|14021351|BAB47964.1|AP002994 FT cyclopropane-fatty-acyl-phospholipid synthase from FT Mesorhizobium loti (378 aa); FT B82240|9655593|AAF94281.1|AE004192 FT cyclopropane-fatty-acyl-phospholipid synthase from Vibrio FT cholerae (432 aa); P30010|CFA_ECOLI FT CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from FT Escherichia coli strain K-12 (382 aa); X55704|PPLPD_3 LPD-3 FT from P.putida (394 aa), FASTA scores: opt: 556, E(): FT 2.8e-30, (33.3% identity in 387 aa overlap); FT AE0005|HPAE000557_9 from Helicobacter pylori (389 aa), FT FASTA scores: opt: 539, E(): 3.9e-29, (34.3% identity in FT 382 aa overlap)." FT /db_xref="GOA:Q7U1Z4" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/TrEMBL:Q7U1Z4" FT /protein_id="CAD93318.1" FT /translation="MTVETSQTPSAAIDSDRWPAVAKVPRGPLAAASAAIANRLLRRTA FT THLPLRLVYSDGTATGAADPRAPSLFIHRPDALARRIGRHGLIGFGESYMAGEWSSKEL FT TRVLTVLAGSVDELVPRSLHWLRPITPTFRPSWPDHSRDQARRNIAVHYDLSNDLFAAF FT LDETMTYSCAMFTDLLAQPTPAWTELAAAQRRKIDRLLDVAGVQQGSHVLEIGTGWGEL FT CIRAAARGAHIRSVTLSVEQQRLARQRVAAAGFGHRVEIDLCDYRDVDGQYDSVVSVEM FT IEAVGYRSWPRYFAALEQLVRPGGPVAIQAITMPHHRMLATRHTQTWIQKYIFPGGLLP FT STQAIIDITGQHTGLRIVDAASLRPHYAETLRLWRERFMQRRDGLAHLGFDEVFARMWE FT LYLAYSEAGFRSGYLDVYQWTLIREGPP" FT CDS complement(194523..195188) FT /transl_table=11 FT /gene="Mb0456c" FT /locus_tag="Mb0456c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0456c, -, len: 221 aa. Equivalent to Rv0448c, len: FT 221 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 221 aa overlap). Conserved hypothetical FT protein, similar to other hypothetical proteins e.g. FT Z74841|BOD5A2_1 from B. oleracea (283 aa), FASTA scores: FT opt: 257, E(): 1.4e-10, (32.0% identity in 197 aa overlap); FT etc. Some similarity to U15183|MLU15183_38 from FT Mycobacterium leprae (82 aa), FASTA scores: opt: 134, E(): FT 0.014, (71.0% identity in 31 aa overlap)." FT /db_xref="InterPro:IPR010775" FT /db_xref="UniProtKB/TrEMBL:Q7U1Z3" FT /protein_id="CAD93319.1" FT /translation="MHHSFAYRSYSWYVDVDNLPQLPWWLRPFARFHADDHFADPFSCP FT PHSSLRDRLDAFFAARGLAVPDGRITALLQARVLGYVFNPLSIFWCHDRDGQLRHVIAE FT VHNTYGGRHAYLLPPADLPVVTAKNFYVSPFHQLAGYYLIRAPRPDRELDVTVTLHRDR FT RQVCPEFTATLRGQRRPATTRQIAMMQIISPLAPMVVAARIRIQGIRLWLRRVPVVPR" FT CDS complement(195248..196567) FT /transl_table=11 FT /gene="Mb0457c" FT /locus_tag="Mb0457c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0457c, -, len: 439 aa. Equivalent to Rv0449c, len: FT 439 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 439 aa overlap). Conserved hypothetical FT protein, some similarity with several hypothetical proteins FT and various enzymes e.g. AAK24569.1|AE005927 amine oxidase, FT flavin-containing from Caulobacter crescentus (454 aa); FT BAB02771.1|AB023036 mycolic acid methyl transferase-like FT protein from Arabidopsis thaliana (842 aa); FT BAB01742.1|AP000374 protein which contains similarity to FT cyclopropane fatty acid synthase from Arabidopsis thaliana FT (793 aa); etc. Has hydrophobic stretch at N-terminus." FT /db_xref="GOA:Q7U1Z2" FT /db_xref="InterPro:IPR002937" FT /db_xref="UniProtKB/TrEMBL:Q7U1Z2" FT /protein_id="CAD93320.1" FT /translation="MQQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHAH FT THYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEMSMSVRADDIG FT LEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARLLREETDNAEDKPETLEAFL FT SRHHFSQYFVDYFITPLVAAVWSCGGADALRYPARYLFVFLDHHGMLSVFGSPTWRTVT FT GGSANYVQAIAAQLDEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQALL FT LLDEPTPAERAVLGAIAYSTNSAQLHTDESVLPRHHRARASWNYLVTPGQHQVVVSYDI FT SRLMRLDGGRRYLVTLGGHDRVDPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVF FT AGAYHGWGFHEDGAASGLRAARRLGADWPAAIPQEAMVAC" FT CDS complement(196607..199510) FT /transl_table=11 FT /gene="mmpL4" FT /locus_tag="Mb0458c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL4" FT /note="Mb0458c, mmpL4, len: 967 aa. Equivalent to Rv0450c, FT len: 967 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 967 aa overlap). Probable mmpL4, FT conserved transmembrane transport protein (see citations FT below), member of RND superfamily, equivalent to FT U1740V|P54881|YV34_MYCLE HYPOTHETICAL 105.2 kDa PROTEIN FT from Mycobacterium leprae (959 aa), FASTA scores: opt: FT 5051, E(): 0, (78.4% identity in 962 aa overlap). Also FT highly similar to other proteins from Mycobacterium FT tuberculosis e.g. Z83860|MTCY98.08 (962 aa), FASTA scores: FT opt: 3917, E(): 0, (61.3% identity in 950 aa overlap), FT MTCY20G9.34, etc. Contains PS00211 ABC transporters family FT signature. BELONGS TO THE MMPL FAMILY. TBparse score is FT 0.948." FT /db_xref="GOA:Q7U1Z1" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/TrEMBL:Q7U1Z1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93321.1" FT /translation="MSTKFANDSNTNARPEKPFIARMIHAFAVPIILGWLAVCVVVTVF FT VPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFAMVIIEGNQPLGDAAHKY FT YDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVE FT AVRSIVESTPAPPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSI FT ITVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRY FT QEARQAGEDKEAAYYTMYRGTAHVILGSGLTITGATFCLSFARMPYFQTLGIPCAVGML FT VAVAVALTLGPAVLHVGSRFGLFDPKRLLKVRGWRRVGTVVVRWPLPVLVATCAIALVG FT LLALPGYKTSYNDRDYLPDFIPANQGYAAADRHFSQARMKPEILMIESDHDMRNPADFL FT VLDKLAKGIFRVPGISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDM FT LKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPI FT RSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQMVAQIPP FT QIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAAKNDDSFYLPPEVFKNK FT DFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIKSIDAIRTAAEESLKGTPLEDAKIYL FT AGTAAVFHDISEGAQWDLLIAAISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFG FT LSVLLWQHILAIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGG FT TGKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAALLGR FT WFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG" FT CDS complement(199507..199929) FT /transl_table=11 FT /gene="mmpS4" FT /locus_tag="Mb0459c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN MMPS4" FT /note="Mb0459c, mmpS4, len: 140 aa. Equivalent to Rv0451c, FT len: 140 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 140 aa overlap). Probable mmpS4, FT conserved membrane protein (see citations below), FT equivalent to U1740W|P54880|YV33_MYCLE HYPOTHETICAL 16.9 FT kDa PROTEIN from Mycobacterium leprae (154 aa), FASTA FT scores: opt: 727, E(): 0, (75.9% identity in 137 aa FT overlap). Also similar to other Mycobacterial proteins e.g. FT Z84725|MTCY04D9.16c from Mycobacterium tuberculosis (142 FT aa), FASTA scores: opt: 451, E(): 3.2e-24, (50.0% identity FT in 138 aa overlap); etc. BELONGS TO THE MMPS FAMILY. FT TBparse score is 0.953." FT /db_xref="GOA:P0A5K3" FT /db_xref="InterPro:IPR008693" FT /db_xref="UniProtKB/Swiss-Prot:P0A5K3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93322.1" FT /translation="MLMRTWIPLVILVVVIVGGFTVHRIRGFFGSENRPSYSDTNLENS FT KPFNPKHLTYEIFGPPGTVADISYFDVNSEPQRVDGAVLPWSLHITTNDAAVMGNIVAQ FT GNSDSIGCRITVDGKVRAERVSNEVNAYTYCLVKSA" FT CDS 200161..200871 FT /transl_table=11 FT /gene="Mb0460" FT /locus_tag="Mb0460" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0460, -, len: 236 aa. Equivalent to Rv0452, len: FT 236 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 236 aa overlap). Possible FT transcriptional regulator, similar to several putative FT TetR-family transcriptional regulators from Streptomyces FT coelicolor. Also similar in N-terminus to FT U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67 FT aa), FASTA score: (76.1% identity in 67 aa overlap). FT Contains probable helix-turn-helix motif at aa 44-65 (Score FT 1727, +5.07 SD)." FT /db_xref="GOA:Q7U1Z0" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U1Z0" FT /protein_id="CAD93323.1" FT /translation="MRYPLAVAQLGFQRARTEENKRQRAAALVEAARSLALETGVASVT FT LTAVAGRAGIHYSAVRRYFTSHKEVLLHLAAEGWARWSGTVCEQLGEPGPMSAPRVAEA FT LANGLAADPLFCDLLANLHLHLEQEVDVDRVIEVKRTSIAAVIALVDAIESALPALGRS FT GAFDILLAAYSLAATLWQIANPPERLTDAYAEEPELLPPEWNLDFAAALTRLLTATLLG FT LLAGSPCECRSPTR" FT CDS 201193..202749 FT /transl_table=11 FT /gene="PPE11" FT /locus_tag="Mb0461" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0461, PPE11, len: 518 aa. Equivalent to Rv0453, FT len: 518 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 518 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family, similar to many e.g. FT AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FT FASTA scores: opt: 882, E(): 7e-31, (41.8% identity in 514 FT aa overlap)." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7U1Y9" FT /protein_id="CAD93324.1" FT /translation="MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGREYAAV FT AEELGALLAAVQAGVWQGPSAESFAAACLPYLSWLTQASADCAAAAARLEAVTAAYAAA FT LVAMPTLAELAANHATHGAMVATNFFGINTIPIAVNEADYVRMWLQAATTMATYQAVAD FT SAVRSIPDSVPPPRILKSNAQSQHSSSNNSGGADPVDDFIAEILKIITGGRVIWDPEAG FT TVNGLPYDAYTNPGTLMWWIARSLELLQDFQEFAKLLFTNPVKAFQFLVDLILFDWPTH FT MLQLATWLAENPQLLVAALTPAISGLGAVSGLAGLTGLVPQPPVVPAPAPDAVVPTVLP FT LAGTATPTTAPASAPAAGAAPGPPAGTATATSASVPTSAGGFPPYLVGSGPGIDFDAGT FT PAGSRRAQPAADNVTAVAAAQVSARHQARRRRRAAAKERGNADEFVDMDSGPAIPPSGE FT RDAWASNSGVGGLGFAGTASNETVAAPAGLTTLADDEFQCGPRMPMLPGAWDLGTWDRG FT D" FT CDS 202854..203204 FT /transl_table=11 FT /gene="Mb0462" FT /locus_tag="Mb0462" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0462, -, len: 116 aa. Equivalent to Rv0454, len: FT 116 aa (start uncertain), from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 116 aa overlap). FT Conserved hypothetical protein, showing similarity with FT AAA63007.1|U15183 hypothetical protein from Mycobacterium FT leprae (115 aa), FASTA scores: opt: 151, E(): 0.0019, FT (31.5% identity in 89 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U1Y8" FT /protein_id="CAD93325.1" FT /translation="MKQDFGLDVPQAGNAQNFDGVPEWVQVGVVTFVYRMQMHHVTRPV FT GAPGSGLAGDSTPVQGRQRVWDLVAGRLTHAPRSSVQAMRPTMFTSAPQRHGIPARGRW FT WLGYQERSRAWP" FT CDS complement(203394..203840) FT /transl_table=11 FT /gene="Mb0463c" FT /locus_tag="Mb0463c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0463c, -, len: 148 aa. Equivalent to Rv0455c, len: FT 148 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 148 aa overlap). Conserved hypothetical FT protein, equivalent to CAC31896.1|AL583925 possible FT secreted protein from Mycobacterium leprae (153 aa). Has FT hydrophobic stretch at N-terminus." FT /db_xref="UniProtKB/TrEMBL:Q7U1Y7" FT /protein_id="CAD93326.1" FT /translation="MSRLSSILRAGAAFLVLGIAAATFPQSAAADSTEDFPIPRRMIAT FT TCDAEQYLAAVRDTSPVYYQRYMIDFNNHANLQQATINKAHWFFSLSPAERRDYSEHFY FT NGDPLTFAWVNHMKIFFNNKGVVAKGTEVCNGYPAGDMSVWNWA" FT CDS complement(203908..204822) FT /transl_table=11 FT /gene="echA2" FT /locus_tag="Mb0464c" FT /product="ENOYL-COA HYDRATASE ECHA2 (ENOYL HYDRASE) FT (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)" FT /EC_number="4.2.1.17" FT /note="Mb0464c, echA2, len: 304 aa. Equivalent to Rv0456c, FT len 304 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 304 aa overlap). Probable echA2, FT enoyl-CoA hydratase (EC 4.2.1.17), similar to other FT enoyl-coA hydratases e.g. Q13011 PEROXISOMAL ENOYL-COA FT HYDRATASE-LIKE PROTEIN (328 aa), FASTA scores: opt: 209, FT E(): 5.3e-07, (31.7% identity in 142 aa overlap). Also FT similar to several other proteins from Mycobacterium FT tuberculosis e.g. MTCY09F9.29 FASTA score: (32.9% identity FT in 146 aa overlap); and MTI376.01c." FT /db_xref="GOA:Q7U1Y6" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:Q7U1Y6" FT /protein_id="CAD93327.1" FT /translation="MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAIGL FT AERDQDIKVIVLRGAGRAFSGGYDFGGGFQHWGDAMMTDGRWDPGKDFAMVTARETGPT FT QKFMAIWRASKPVIAQVHGWCVGGASDYALCADIVIASEDAVIGTPYSRMWGAYLTGMW FT LYRLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELARIPLSQLQ FT AQKLIVNQAYENMGLASTQLLGGILDGLMRNTPDALEFIRTAQTQGVRAAVERRDGPFG FT DYSQAPPELRPDPTHVITPDGSM" FT CDS complement(205095..205376) FT /transl_table=11 FT /gene="Mb0465c" FT /locus_tag="Mb0465c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0465c, -, len: 93 aa. Equivalent to Rv0456A, len: FT 93 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 93 aa overlap). Conserved hypothetical FT protein; N-terminus highly similar to N-terminal part of FT P71650|Rv2801c|MT2869|MTCY16B7.42 CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (118 aa), FASTA FT scores: opt: 303, E(): 1e-14, (60.44% identity in 91 aa FT overlap). Also some similarity in part with other FT hypothetical proteins e.g. Q9PHH8|XFA0027 Plasmid FT maintenance protein from Xylella fastidiosa (108 aa), FASTA FT scores: opt: 169, E(): 3.9e-05, (50.820% identity in 61 aa FT overlap)." FT /db_xref="GOA:Q7U1Y5" FT /db_xref="InterPro:IPR003477" FT /db_xref="UniProtKB/TrEMBL:Q7U1Y5" FT /protein_id="CAD93328.1" FT /translation="MLRGEIWQVDLDPARGSAANMRRPAVIVSNDRANAAAIRLDRGVV FT PVVPVTSNTEKVPIPGVVAGSERWPGRRFEGAGPAGWIRRCATSPLPS" FT CDS complement(205605..207635) FT /transl_table=11 FT /gene="Mb0466c" FT /locus_tag="Mb0466c" FT /product="PROBABLE PEPTIDASE" FT /EC_number="3.4.-.-" FT /note="Mb0466c, -, len: 676 aa. Equivalent to Rv0457c, len: FT 673 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 673 aa overlap). Probable peptidase (EC FT 3.4.-.-), similar to many e.g. FT NP_102851.1|14022026|BAB48637.1 probable endopeptidase from FT Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable FT peptidase (EC 3.4.21.-) (726 aa), FASTA scores: opt: 1126, FT E(): 0, (40.9% identity in 491 aa overlap). Also similar to FT Mycobacterium tuberculosis protein MTCY369.26 FASTA score: FT (33.8% identity in 299 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT possible RBS upstream leads to an earlier start resulting FT in a slightly longer product compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 FT aa)." FT /db_xref="GOA:Q7U1Y4" FT /db_xref="InterPro:IPR002470" FT /db_xref="UniProtKB/TrEMBL:Q7U1Y4" FT /protein_id="CAD93329.1" FT /translation="MASMTFEPAPDGADPYLWLEDVTGAEALDWVRARNKPTTAAFCDA FT EFERMRVEALEVLDTDARIPYVNRRGNYLYNFWRDAANPRGLWRRTTLDSYRTDSPGWD FT VLIDVDELGRADDQKWVWGGAGVIEPDYTRALIGLSPGGSDASIVREFDMLTREFVEDG FT FQLPPAKSQITWEDPDTVLLGTDFGGDSLTTSGYPRVIKRWRRGKPLADAETIFEGAGT FT DVRVNASADRTPGFERTLLGRALDFWNEEVYELRGSELIRIEAPTDASVSIHRDWLLIE FT LRTDWTVATTRYTAGSLLAAEYDEFLAGSAELQVVFEPDEHTALYQYAWTRDRLLIVTL FT ADVASRVEIATPGSWRREPLSGIPAATNTVIVSADSHGDEFFLDSSGFDTPSRLMRGTD FT DGRLAEIKSAPAFFDAENMAVTQYFATSDDGTSIPYFVVRRTDADNPGPTLLNGYGGFE FT TSRTPTYDGVLGRLWLARGGTYALANIRGGGEYGPGWHTQAMREGRDKVAQDFAAVATD FT LVTRGITTAEQLGARGGSNGGLLMGIMLTGYPEKFGALVCDVPLLDMKRYHLLLAGASW FT MAEYGDPDNPDDWKFISEYSPYQNISANRKYPPVLMTTSTRDDRVHPGHARKMTAALQA FT AGHPVWYYENIEGGHAGAADNAQIAFKSALSFAFLWRMLAG" FT CDS 207694..209217 FT /transl_table=11 FT /gene="Mb0467" FT /locus_tag="Mb0467" FT /product="PROBABLE ALDEHYDE DEHYDROGENASE" FT /EC_number="1.2.1.3" FT /note="Mb0467, -, len: 507 aa. Equivalent to Rv0458, len: FT 507 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 507 aa overlap). Probable aldehyde FT dehydrogenase (EC 1.2.1.3), highly similar to many, closest FT to P46369|THCA_RHOER EPTC-INDUCIBLE ALDEHYDE DEHYDROGENASE FT from Rhodococcus erythropolis (506 aa), FASTA scores: opt: FT 2767, E(): 0, (79.7% identity in 507 aa overlap); FT AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from FT Xanthobacter autotrophicus (505 aa), FASTA scores: opt: FT 2563, E(): 0, (75.4% identity in 492 aa overlap); FT Q9RJZ6|DHAL_STRCO PROBABLE ALDEHYDE DEHYDROGENASE from FT Streptomyces coelicolor (507 aa). Also similar to other FT semialdehyde dehydrogenases in M. tuberculosis e.g. Rv0768, FT Rv2858c. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY." FT /db_xref="GOA:P63938" FT /db_xref="HSSP:1O04" FT /db_xref="InterPro:IPR015590" FT /db_xref="UniProtKB/Swiss-Prot:P63938" FT /protein_id="CAD93330.1" FT /translation="MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVTG FT QPFCEVPRSDAADIDKALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALAVAEV FT WDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDTVAYHFHEPLGVVGQII FT PWNFPILMAAWKLAPALAAGNTAVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVNGFGA FT EAGKPLASSDRIAKVAFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHD FT DFCDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLDTETM FT LGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGTNNMRI FT FKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTAYRAGRDIQAGRVWVN FT CYHLYPAHAAFGGYKQSGIGREGHQMMLQHYQHTKNLLVSYSDKALGFF" FT CDS 209217..209708 FT /transl_table=11 FT /gene="Mb0468" FT /locus_tag="Mb0468" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0468, -, len: 163 aa. Equivalent to Rv0459, len: FT 163 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 163 aa overlap). Conserved hypothetical FT protein, highly similar to other hypothetical proteins. FT Note that highly similar to products of unidentified orfs FT in Xanthobacter autotrophicus, AF029733_2 (139 aa), and FT Rhodococcus erythropolis, REREUTP BC_1 (186 aa). Like FT MTV038.03, these ORF's are linked to aldehyde dehydrogenase FT genes. FASTA scores: AF0297|AF029733_2 (139 aa), opt: 439, FT E(): 6.2e-24, (50.0% identity in 126 aa overlap); and FT L24492|REREUTPBC_1 (186 aa), opt: 347, E(): 2.1e-17, (52.7% FT identity in 169 aa overlap). N-terminus also highly similar FT to AAA63041.1|U15183 ethanolamine permease (eutP) match FT from Mycobacterium leprae (53 aa)." FT /db_xref="InterPro:IPR008497" FT /db_xref="UniProtKB/TrEMBL:Q7U1Y3" FT /protein_id="CAD93331.1" FT /translation="MNAPAGVLITAEAAALLAGLQDRHGPVMFHQSGGCCDGSAPMCYP FT RADFLVGDRDILLGVLDVGEDGVPVWISGPQYQAWKHTQLIIDVVPGRGGGFSLEAPEG FT VRFLSRGRVFSDAEKAMREAAPVITGAAYECGERPLVRGLVVDLDDPDATPGVCRASRR FT " FT CDS 209768..210007 FT /transl_table=11 FT /gene="Mb0469" FT /locus_tag="Mb0469" FT /product="CONSERVED HYDROPHOBIC PROTEIN" FT /note="Mb0469, -, len: 79 aa. Equivalent to Rv0460, len: 79 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 79 aa overlap). Conserved hydrophobic protein, FT highly similar AAA63024.1|U15183 hypothetical protein from FT Mycobacterium leprae (56 aa), FASTA scores: opt: 197, E(): FT 3.7e-09, (63.8% identity in 47 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U1Y2" FT /protein_id="CAD93332.1" FT /translation="MLVGNAIGLLAGVACSVLVHARIRPDIVIAMVVGIPSAIGLLVIL FT FSGRRWVTMLGAFILALAPGWFGVLVAIQVASSG" FT CDS 210045..210569 FT /transl_table=11 FT /gene="Mb0470" FT /locus_tag="Mb0470" FT /product="PROBABLE TRANSMEMBRANE PROTEIN" FT /note="Mb0470, -, len: 174 aa. Equivalent to Rv0461, len: FT 174 aa (start uncertain), from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 174 aa overlap). Probable FT transmembrane protein." FT /db_xref="GOA:Q7U1Y1" FT /db_xref="UniProtKB/TrEMBL:Q7U1Y1" FT /protein_id="CAD93333.1" FT /translation="MPDFDTGAHSQRFLSLAGQQDRAGKSWPGSTPKPQEDPVGVAPSA FT SVEVLGSEPAATLAHSVTVPGRYTYLKWWKFVLVVLGVWIGAGEVGLSLFYWWYHTLDK FT TAAVFVVLVYVVACTVGGLILALVPGRPLITALSLGVMSGPFASVAAAAPLYGYYYCER FT MSHCLVGVIPY" FT CDS 210633..212027 FT /transl_table=11 FT /gene="lpd" FT /locus_tag="Mb0471" FT /standard_name="TB49.2" FT /product="DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE FT REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL FT DEHYDROGENASE) (DIAPHORASE)" FT /EC_number="1.8.1.4" FT /note="Mb0471, lpd, len: 464 aa. Equivalent to Rv0462, len: FT 464 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 464 aa overlap). lpd (alternate gene FT name: TB49.2), dihydrolipoamide dehydrogenase (EC 1.8.1.4) FT (see first citation below), equivalent to AAA63016.1|U15183 FT lipoamide dehydrogenase from Mycobacterium leprae (467 aa), FT FASTA scores: opt: 2583, E(): 0, (83.1% identity in 467 aa FT overlap). Also similar to to many e.g. FT P50970|DLDH_ZYMMO|X82291|ZMLPD_1 DIHYDROLIPOAMIDE FT DEHYDROGENASE from Z.mobilis (466 aa), FASTA scores: opt: FT 1198, E(): 0, (42.4 % identity in 465 aa overlap); etc. FT BELONG TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES FT CLASS-I." FT /db_xref="GOA:P66005" FT /db_xref="HSSP:1EBD" FT /db_xref="InterPro:IPR001327" FT /db_xref="UniProtKB/Swiss-Prot:P66005" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93334.1" FT /translation="MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVG FT CIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKN FT KITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEE FT QILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQF FT KKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKA FT GVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLG FT DHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVA FT DAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLV FT GHMINF" FT CDS 212035..212328 FT /transl_table=11 FT /gene="Mb0472" FT /locus_tag="Mb0472" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0472, -, len: 97 aa. Equivalent to Rv0463, len: 97 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 97 aa overlap). Probable conserved FT transmembrane protein, highly similar to AAA63017.1|U15183 FT hypothetical protein from Mycobacterium leprae (101 aa), FT FASTA scores: opt: 364, E(): 4e-21, (57.9% identity in 95 FT aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U1Y0" FT /protein_id="CAD93335.1" FT /translation="MTRRASTDTPQIIMGAIGGVVTGYILWLAAISVGDGLTTVSQWSR FT VVLLLSVLVAVCGAAGGLRLRSRGKLAWSAFAFSLPIPPVVLTVAVLADIYL" FT CDS complement(212332..212904) FT /transl_table=11 FT /gene="Mb0473c" FT /locus_tag="Mb0473c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0473c, -, len: 190 aa. Equivalent to Rv0464c, len: FT 190 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 190 aa overlap). Conserved hypothetical FT protein, highly similar to CAC31982.1|AL583925 conserved FT hypothetical protein from Mycobacterium leprae (188 aa). FT Also some similarity with Rv1531|AL022000|MTV045_5|D70820 FT hypothetical protein from Mycobacterium tuberculosis (188 FT aa), FASTA scores: E(): 9.6e-10, (30.9% identity in 175 aa FT overlap)." FT /db_xref="InterPro:IPR003779" FT /db_xref="UniProtKB/TrEMBL:Q7U1X9" FT /protein_id="CAD93336.1" FT /translation="MTGQNGQVARISPGKFRQLGPVNWLVAKLAARAVGAPQMHLFTTL FT GYRQYLFWTFAIYTGRLLHGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDAN FT TQATIFAWPDVPDGDGPRKVLSARQQALLQATDELIKDRTITAGTWERLATHLDPRLLI FT EFCLLATQYDAIAATITALAIPPDNPQ" FT CDS complement(212901..214325) FT /transl_table=11 FT /gene="Mb0474c" FT /locus_tag="Mb0474c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0474c, -, len: 474 aa. Equivalent to Rv0465c, len: FT 474 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 474 aa overlap). Probable FT transcriptional regulator, highly similar to FT AC44331.1|AL596102 putative DNA-binding protein from FT Streptomyces coelicolor (489 aa); and similar to several FT hypothetical proteins and others transcriptional FT regulators. Some similarity in N-terminal region (1-100 aa) FT with repressors e.g. P06153|RPC_BPPH1 IMMUNITY REPRESSOR FT PROTEIN (144 aa), FASTA scores: opt: 130, E(): 0.084,(27.0% FT identity in 100 aa overlap). Very similar to FT Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium tuberculosis FT (486 aa), FASTA scores: opt: 1475, E(): 0, (47.4% identity FT in 468 aa overlap). Contains probable helix-turn-helix FT motif at aa 19-40 (1827, +5.41 SD)." FT /db_xref="GOA:Q7U1X8" FT /db_xref="InterPro:IPR018653" FT /db_xref="UniProtKB/TrEMBL:Q7U1X8" FT /protein_id="CAD93337.1" FT /translation="MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLDQIEHDVRPL FT TVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHPGL FT ARAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHALDTA FT AEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLS FT PGQQVFKMAAELAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFH FT DVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVQVDRAGNMSKRQSAT FT GFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKT FT FAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALD FT LDEHRSTVSPYLVKQL" FT CDS 214477..215271 FT /transl_table=11 FT /gene="Mb0475" FT /locus_tag="Mb0475" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0475, -, len: 264 aa. Equivalent to Rv0466, len: FT 264 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 264 aa overlap). Conserved hypothetical FT protein, equivalent to CAC31980.1|AL583925 conserved FT hypothetical protein from Mycobacterium leprae (264 aa). FT Similar to Rv2001|Z74025|MTCY39.17c HYPOTHETICAL 28.7 KDA FT PROTEIN from Mycobacterium tuberculosis (250 aa), FASTA FT scores: opt: 592, E(): 0, (38.0% identity in 263 aa FT overlap). Some similarity to several THIOESTERASES e.g. FT Q42561|ATACPTE17_1 ACYL-(ACYL CARRIER PROTEIN) THIOESTER FT from A. thaliana (362 aa), FASTA scores: E(): 0.0092, FT (24.4% identity in 197 aa overlap)." FT /db_xref="InterPro:IPR002864" FT /db_xref="UniProtKB/TrEMBL:Q7U1X7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93338.1" FT /translation="MSLDKKLMPVPDGHPDVFDREWPLRVGDIDRAGRLRLDAACRHIQ FT DIGQDQLREMGFEETHPLWIVRRTMVDLIRPIEFGDMLRCRRWCSGTSNRWCEMRVRVD FT GRKGGLIESEAFWIHVNRETEMPARIADDFLAGLHRTTSVDRLRWKGYLKPGSRDDASE FT IHEFPVRVTDIDLFDHMNNAVYWSVIEDYLASHAELLRGPLRVTIEHEAPVALGDKLEI FT ISHVHPAGSTEIFGPGLVDRAVTTLTYVVGDEPKAVASLFNL" FT CDS 215546..216832 FT /transl_table=11 FT /gene="icl" FT /locus_tag="Mb0476" FT /product="ISOCITRATE LYASE ICL (ISOCITRASE) (ISOCITRATASE)" FT /EC_number="4.1.3.1" FT /note="Mb0476, icl, len: 428 aa. Equivalent to Rv0467, len: FT 428 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 428 aa overlap). icl (previously known FT as aceA), isocitrate lyase (EC 4.1.3.1) (see citations FT below), highly similar to many, closest to FT Z29367|RFISCILY_1 from R. fascians (429 aa), FASTA scores: FT opt: 2359, E(): 0, (80.7% identity in 429 aa overlap). FT BELONGS TO THE ISOCITRATE LYASE FAMILY." FT /db_xref="GOA:P0A5H4" FT /db_xref="InterPro:IPR015813" FT /db_xref="UniProtKB/Swiss-Prot:P0A5H4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93339.1" FT /translation="MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEE FT HTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGH FT TYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALN FT VYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVP FT TVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADL FT IWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMG FT FKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA FT GYFDRIATTVDPNSSTTALTGSTEEGQFH" FT CDS 216914..217774 FT /transl_table=11 FT /gene="fadB2" FT /locus_tag="Mb0477" FT /product="PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE FADB2 FT (BETA-HYDROXYBUTYRYL-COA DEHYDROGENASE) (BHBD)" FT /EC_number="1.1.1.157" FT /note="Mb0477, fadB2, len: 286 aa. Equivalent to Rv0468, FT len: 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 286 aa overlap). Probable fadB2, FT 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), FT equivalent to CAC31978.1|AL583925 3-hydroxyacyl-CoA FT dehydrogenase from Mycobacterium leprae (287 aa). Also FT similar to many 3-hydroxybutyryl-CoA dehydrogenases e.g. FT U32229|BJU32229_1 beta-hydroxybutyryl coenzyme A FT dehydrogenase from Bradyrhizobium japonicum (293 aa), FASTA FT scores: opt: 771, E(): 0, (45.7% identity in 282 aa FT overlap). BELONGS TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FT FAMILY." FT /db_xref="GOA:Q7U1X6" FT /db_xref="HSSP:1F0Y" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U1X6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93340.1" FT /translation="MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGR FT NRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEIFA FT ELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRVLGLHFFNPVPVLPLVELVRTLVTD FT EAAAARTEEFASTVLGKQVVRCSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAV FT VAGLSHPMGPLRLSDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGR FT GFYTY" FT CDS 217907..218767 FT /transl_table=11 FT /gene="umaA1" FT /locus_tag="Mb0478" FT /product="POSSIBLE MYCOLIC ACID SYNTHASE UMAA1" FT /EC_number="2.-.-.-" FT /note="Mb0478, umaA1, len: 286 aa. Equivalent to Rv0469, FT len: 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 286 aa overlap). Possible umaA1, FT mycolic acid synthase (EC 2.-.-.-), highly similar to FT CAC30854.1|AL583923 methyl mycolic acid synthase 1 from FT Mycobacterium leprae (286 aa); and CAC31976.1|AL583925 FT Mycolic acid synthase from Mycobacterium leprae (295 aa), FT FASTA scores: opt: 1402, E(): 0, (69.6% identity in 286 aa FT overlap). Also very similar to mycobacterial FT methyltransferases e.g. U77466|CmaD|MBU77466_1 (286 aa); FT MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar FT to CFA1_MYCTU|Q11195|U66108|MTU66108_1 FT cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa), FT FASTA scores: opt: 1360, E(): 0, (67.8% identity in 286 aa FT overlap) (see citation below); and very similar also to FT methoxy mycolic acid synthase 1 from Mycobacterium FT tuberculosis e.g. MTU66108_1 (286 aa)." FT /db_xref="GOA:Q7U1X5" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/TrEMBL:Q7U1X5" FT /protein_id="CAD93341.1" FT /translation="MTELRPFYEESQSIYDVSDEFFSLFLDPTMAYTCAYFEREDMTLE FT EAQNAKFDLALDKLHLEPGMTLLDIGCGWGGGLQRAIENYDVNVIGITLSRNQFEYSKA FT KLAKIPTERSVQVRLQGWDEFTDKVDRIVSIGAFEAFKMERYAAFFERSYDILPDDGRM FT LLHTILTYTQKQMHEMGVKVTMSDVRFMKFIGEEIFPGGQLPAQEDIFKFAQAADFSVE FT KVQLLQQHYARTLNIWAANLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGISNVGQ FT FTLTK" FT CDS complement(218867..219730) FT /transl_table=11 FT /gene="pcaA" FT /locus_tag="Mb0479c" FT /product="MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE FT SYNTHASE)" FT /EC_number="2.-.-.-" FT /note="Mb0479c, pcaA, len: 287 aa. Equivalent to Rv0470c, FT len: 287 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 287 aa overlap). pcaA (previously known FT as umaA2), mycolic acid synthase (cyclopropane synthase) FT (EC 2.-.-.-) (see citations below), equivalent to FT CAC31976.1|AL583925 Mycolic acid synthase from FT Mycobacterium leprae (295 aa); and highly similar to FT S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical FT protein from Mycobacterium leprae (308 aa); FT Q11195|CFA1_MYCTU CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID FT SYNTHASE 1 (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1) (287 aa) FT (see second citation below); U27357|MTU27357_1 cyclopropane FT mycolic acid synthase from Mycobacterium tuberculosis (287 FT aa), FASTA scores: opt: 1415, E(): 0, (72.8% identity in FT 287 aa overlap); and related enzymes e.g. FT MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa), FASTA scores: FT opt: 1387, E(): 0, (72.5% identity in 287 aa overlap)." FT /db_xref="GOA:Q7U1X4" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/TrEMBL:Q7U1X4" FT /protein_id="CAD93342.1" FT /translation="MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTL FT QEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAGHVQ FT KMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGHQRYHHFFEVTHRTLPADGK FT MLLHTIVRPTFKEGREKGLTLTHELVHFTKFILAEIFPGGWLPSIPTVHEYAEKVGFRV FT TAVQSLQLHYARTLDMWATALEANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQGYTDVD FT QFTLEK" FT CDS complement(219873..220313) FT /transl_table=11 FT /gene="Mb0480c" FT /locus_tag="Mb0480c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0480c, -, len: 146 aa. Equivalent to Rv0470A, len: FT 146 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 146 aa overlap). Hypothetical unknown FT protein. GC plot suggests CDS for Cys-rich protein, could FT possibly be continuation of Rv0471c but no frameshift found FT to allow this. Sequence same in Mycobacterium bovis and FT CDC1551. Weak hits to Cys-rich region (aa 258-314) of FT D63395|D63395_1 mRNA for NOTCH4 from Homo sapiens (1095 FT aa), FASTA scores: opt: 132, E(): 1.1, (39.35% identity in FT 61 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U1X3" FT /protein_id="CAD93343.1" FT /translation="MGAGGWEVVLASLPYGLLCTTVLMGKHIDKIGYDEPLGIRTLPVL FT LGETCARTVTLAMMVGFYLLIAVNVMLAAMPWPRCWSPGRCPGWRKCGPISCDGGPSSR FT HRRFRCGRCGMPRWPGCTCVRPVRCWLWAWRSVPGGAPGDFR" FT CDS complement(220244..220732) FT /transl_table=11 FT /gene="Mb0481c" FT /locus_tag="Mb0481c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0481c, -, len: 162 aa. Equivalent to Rv0471c, len: FT 162 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 162 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U1X2" FT /protein_id="CAD93344.1" FT /translation="MPDAGAGSRLRSWAYALRTTNPPADGPTDTVTRWLVVTRAAVLPM FT TLVSGLVAGLLAIGEPGLDWRWLVLWWESHAPHIANNLMNDLYDTDVGTDSATYARARY FT AQHPAATGANRAAYTTPRRTTSCGSPERALEPTTPRWARAVGRSCWRRSPTGCCAPRC" FT CDS complement(220742..221446) FT /transl_table=11 FT /gene="Mb0482c" FT /locus_tag="Mb0482c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /note="Mb0482c, -, len: 234 aa. Equivalent to Rv0472c, len: FT 234 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 234 aa overlap). Probable regulatory FT protein, possibly tetR family, equivalent to FT CAC31974.1|AL583925 possible TetR-family transcriptional FT regulator from Mycobacterium leprae (233 aa). Also similar FT to CAC01492.1|AL391017 putative transcriptional regulatory FT protein from Streptomyces coelicolor (218 aa); and FT CAC01371.1|AL390975 putative tetR-family transcriptional FT regulator from Streptomyces coelicolor (228 aa). Also FT similar to AL0212|MTV012_65 from Mycobacterium tuberculosis FT (246 aa), FASTA scores: opt: 327, E(): 1.8e-15, (31.0% FT identity in 232 aa overlap); and Z95120|MTCY07D11.18c (228 FT aa), FASTA scores: opt: 190, E(): 4.4e-06, (23.1% identity FT in 186 aa overlap). Contains probable helix-turn-helix FT doimain at aa 45-66 (Score 1429, +4.05 SD)." FT /db_xref="GOA:Q7U1X1" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U1X1" FT /protein_id="CAD93345.1" FT /translation="MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRFL FT SMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGFELTRE FT IIRVYVETVAAQPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMDTGG FT VEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKFREQP FT HPSPIVPAWGQV" FT CDS 221583..222953 FT /transl_table=11 FT /gene="Mb0483" FT /locus_tag="Mb0483" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0483, -, len: 456 aa. Equivalent to Rv0473, len: FT 456 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 456 aa overlap). Possible conserved FT transmembrane protein, showing some similarity to FT hypothetical proteins e.g. FT NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical FT protein from Mesorhizobium loti (431 aa); FT P39385|YJIN_ECOLI|YJIN|B4336 HYPOTHETICAL 48.2 KD PROTEIN FT (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli FT strain K12 (426 aa), FASTA scores: opt: 396, E(): 9.8e-19, FT (31.8 % identity in 424 aa overlap); etc." FT /db_xref="GOA:Q7U1X0" FT /db_xref="InterPro:IPR007383" FT /db_xref="UniProtKB/TrEMBL:Q7U1X0" FT /protein_id="CAD93346.1" FT /translation="MVAHRAEVSGSPPPRLNLSTQPTVARRVRASFAESFAAADPEADA FT ARRMALRRMKVVAVGFLVGATGVFLACRWAQADGADHAWLGYLGAAAEAGMVGALADWF FT AVTALFKHPLGIPIPHTAIIKRKKDQLGEGLGTFVRENFLSPPVVETKLRDAQIPSRLG FT KWLSEATHAQRVAAETATVLRVLVELLRDEDIQQVIDRMIVRRIAEPQWGPPAGRVLAT FT LLAENRQEAFIQLLADRAFQWSLNAGVVIQRVVERDSPSWSPRFIDHLVGDRIHRELME FT FTDKVRRNPDHELRRSATRFLFDFADDLQHDPATVARADAIKEELMARDEIATAAAAAW FT KTLKRLVLEGVDDPSSALRTRITDAVIRIGESLRDDADLRDKVDSWTVRAAQHLVSEYG FT VEITAIITETIERWDAEEASRRIELHVGRDLQFIRINGTVVGAMAGLAIYAIAQLLF" FT CDS 223040..223462 FT /transl_table=11 FT /gene="Mb0484" FT /locus_tag="Mb0484" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0484, -, len: 140 aa. Equivalent to Rv0474, len: FT 140 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 140 aa overlap). Probable FT transcriptional regulator, highly similar to others e.g. FT CAC04034.1|AL391406 putative DNA-binding protein from FT Streptomyces coelicolor (141 aa); N-terminus of FT NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional FT regulator from Mesorhizobium loti (219 aa); N-terminus of FT A83618|PA0225 probable transcription regulator from FT Pseudomonas aeruginosa (179 aa); SINR_BACSU|P06533 sinr FT protein from Bacillus subtilis (111 aa), FASTA scores: opt: FT 147, E(): 8.9e-06, (30.6% identity in 111 aa overlap). Also FT similar to other hypothetical proteins e.g. FT X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa), FASTA FT scores: opt: 280, E(): 4.8e-12, (43.6% identity in 117 aa FT overlap). Also similar to Rv2745c from Mycobacterium FT tuberculosis. Contains probable helix-turn-helix domain at FT aa 35-56 (Score 1709, +5.01 SD)." FT /db_xref="GOA:Q7U1W9" FT /db_xref="HSSP:1B0N" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/TrEMBL:Q7U1W9" FT /protein_id="CAD93347.1" FT /translation="MSSEEKLAAKVSTKASDVASDIGSFIRSQRETAHVSMRQLAERSG FT VSNPYLSQVERGLRKPSADVLSQIAKALRVSAEVLYVRAGILEPSETSQVRDAIITDTA FT ITERQKQILLDIYASFTHQNEATREECPSDPTPTDD" FT CDS 223816..224415 FT /transl_table=11 FT /gene="hbhA" FT /locus_tag="Mb0485" FT /product="HEPARIN BINDING HEMAGGLUTININ HBHA (ADHESIN)" FT /note="Mb0485, hbhA, len: 199 aa. Equivalent to Rv0475, FT len: 199 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 199 aa overlap). hbhA, heparin-binding FT hemagglutinin (see citations below), equivalent to FT CAC31971.1|AL583925 possible hemagglutinin from FT Mycobacterium leprae (188 aa). Contains possible N-terminal FT signal sequence and K-A-rich region at C-terminus: FT SUBCELLULAR LOCATION: SURFACE ASSOCIATED." FT /db_xref="GOA:P0C2T3" FT /db_xref="UniProtKB/Swiss-Prot:P0C2T3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93348.1" FT /translation="MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTD FT TRSRVEESRARLTKLQEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERGEA FT ALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPKKA FT APAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK" FT CDS 224527..224790 FT /transl_table=11 FT /gene="Mb0486" FT /locus_tag="Mb0486" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0486, -, len: 87 aa. Equivalent to Rv0476, len: 87 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 87 aa overlap). Possible conserved FT transmembrane protein, equivalent to CAC31970.1|AL583925 FT conserved membrane protein from Mycobacterium leprae (95 FT aa). Also highly similar to CAC04036.1|AL391406 putative FT membrane protein from Streptomyces coelicolor (113 aa). FT Contains PS00606 Beta-ketoacyl synthases active site." FT /db_xref="GOA:P64696" FT /db_xref="InterPro:IPR019662" FT /db_xref="UniProtKB/Swiss-Prot:P64696" FT /protein_id="CAD93349.1" FT /translation="MLVLLVAVLVTAVYAFVHAALQRPDAYTAADKLTKPVWLVILGAA FT VALASILYPVLGVLGMAMSACASGVYLVDVRPKLLEIQGKSR" FT CDS 224795..225241 FT /transl_table=11 FT /gene="Mb0487" FT /locus_tag="Mb0487" FT /product="POSSIBLE CONSERVED SECRETED PROTEIN" FT /note="Mb0487, -, len: 148 aa. Equivalent to Rv0477, len: FT 148 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 148 aa overlap). Possible conserved FT secreted protein, equivalent to CAC31969.1|AL583925 FT hypothetical protein from Mycobacterium leprae (123 aa). FT Also similar to G83406|PA1914 conserved hypothetical FT protein from Pseudomonas aeruginosa (408 aa). Contains FT possible N-terminal signal sequence." FT /db_xref="InterPro:IPR019719" FT /db_xref="UniProtKB/Swiss-Prot:P64698" FT /protein_id="CAD93350.1" FT /translation="MKALVAVSAVAVVALLGVSSAQADPEADPGAGEANYGGPPSSPRL FT VDHTEWAQWGSLPSLRVYPSQVGRTASRRLGMAAADAAWAEVLALSPEADTAGMRAQFI FT CHWQYAEIRQPGKPSWNLEPWRPVVDDSEMLASGCNPGSPEESF" FT CDS 225241..225915 FT /transl_table=11 FT /gene="deoC" FT /locus_tag="Mb0488" FT /product="PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC FT (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE)" FT /EC_number="4.1.2.4" FT /note="Mb0488, deoC, len: 224 aa. Equivalent to Rv0478, FT len: 224 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 224 aa overlap). Probable deoC, FT deoxyribose-phosphate aldolase (EC 4.1.2.4), equivalent to FT Q9CB45|DEOC_MYCLE DEOXYRIBOSE-PHOSPHATE ALDOLASE from M. FT leprae (226 aa). Also highly similar to others e.g. FT DEOC_BACSU|P39121 from Bacillus subtilis (214 aa), FASTA FT scores: opt: 543, E(): 1.4e-26, (45.9% identity in 209 aa FT overlap); etc. BELONGS TO THE DEOC/FBAB FAMILY OF FT ALDOLASES, DEOC SUBFAMILY." FT /db_xref="GOA:P63930" FT /db_xref="HSSP:1O0Y" FT /db_xref="InterPro:IPR002915" FT /db_xref="UniProtKB/Swiss-Prot:P63930" FT /protein_id="CAD93351.1" FT /translation="MLGQPTRAQLAALVDHTLLKPETTRADVAALVAEAAELGVYAVCV FT SPSMVPVAVQAGGVRVAAVTGFPSGKHVSSVKAHEAAAALASGASEIDMVIDIGAALCG FT DIDAVRSDIEAVRAAAAGAVLKVIVESAVLLGQSNAHTLVDACRAAEDAGADFVKTSTG FT CHPAGGATVRAVELMAETVGPRLGVKASGGIRTAADAVAMLNAGATRLGLSGTRAVLDG FT LS" FT CDS complement(225940..226986) FT /transl_table=11 FT /gene="Mb0489c" FT /locus_tag="Mb0489c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0489c, -, len: 348 aa. Equivalent to Rv0479c, len: FT 348 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 348 aa overlap). Probable conserved FT membrane protein, equivalent to CAC31967.1|AL583925 FT possible secreted protein from Mycobacterium leprae (254 FT aa); and C-terminus highly similar to FT AAF74996.1|AF143402_1|AF143402 putative multicopper oxidase FT from Mycobacterium avium (149 aa). Contains hydrophobic FT domain in centre of protein." FT /db_xref="GOA:P64700" FT /db_xref="UniProtKB/Swiss-Prot:P64700" FT /protein_id="CAD93352.1" FT /translation="MTNPQGPPNDPSPWARPGDQGPLARPPASSEASTGRLRPGEPAGH FT IQEPVSPPTQPEQQPQTEHLAASHAHTRRSGRQAAHQAWDPTGLLAAQEEEPAAVKTKR FT RARRDPLTVFLVLIIVFSLVLAGLIGGELYARHVANSKVAQAVACVVKDQATASFGVAP FT LLLWQVATRHFTNISVETAGNQIRDAKGMQIKLTIQNVRLKNTPNSRGTIGALDATITW FT SSEGIKESVQNAIPILGAFVTSSVVTHPADGTVELKGLLNNITAKPIVAGKGLELQIIN FT FNTLGFSLPKETVQSTLNEFTSSLTKNYPLGIHADSVQVTSTGVVSRFSTRDAAIPTGI FT QNPCFSHI" FT CDS complement(226983..227918) FT /transl_table=11 FT /gene="Mb0490c" FT /locus_tag="Mb0490c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0490c, -, len: 311 aa. Equivalent to Rv0480c, len: FT 340 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 311 aa overlap). Conserved hypothetical FT protein, equivalent, but longer 60 aa in N-terminus, to FT CAC31966.1|AL583925 putative hydrolase from Mycobacterium FT leprae (271 aa). Also similar to several hypothetical FT proteins and hydrolases e.g. AL096822|SCGD3_8 probable FT hydrolase from Streptomyces coelicolor (264 aa), FASTA FT scores: opt: 368, E(): 6.1e-15, (34.2% identity in 272 aa FT overlap); and YAUB_SCHPO|Q10166 hypothetical 35.7 kd FT protein c26a3.11 from S. pombe (322 aa), FASTA scores: opt: FT 338, E():1.4e-13, (30.3% identity in 277 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 56 FT bp deletion results in a different NH2 part and leads to a FT shorter product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (329 aa versus 340 aa)." FT /db_xref="GOA:Q7U1W8" FT /db_xref="HSSP:1EMS" FT /db_xref="InterPro:IPR003010" FT /db_xref="UniProtKB/TrEMBL:Q7U1W8" FT /protein_id="CAD93353.1" FT /translation="MRRARRRAQAGLPGSCARRCGALVAGPRLARMRIALAQIRSGTDP FT AANLQLVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEPVDGPWANGVRRIATEAG FT ITVIAGMFTPTGDGRVTNTLIAAGPGTPNQPDAHYHKIHLYDAFGFTESRTVAPGREPV FT VVVVDGVRVGLTVCYDIRFPALYTELARRGAQLIAVCASWGSGPGKLEQWTLLARARAL FT DSMSYVAAAGQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADID FT VDNVAAARDRIAVLRNQTDFVQIDKAQSRG" FT CDS complement(227951..228475) FT /transl_table=11 FT /gene="Mb0491c" FT /locus_tag="Mb0491c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0491c, -, len: 174 aa. Equivalent to Rv0481c, len: FT 174 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 174 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR019639" FT /db_xref="UniProtKB/Swiss-Prot:P64702" FT /protein_id="CAD93354.1" FT /translation="MPRSFDMSADYEGSVEEVHRAFYEADYWKARLAETPVDVATLESI FT RVGGDSGDDGTIEVVTLQMVRSHNLPGLVTQLHRGDLSVRREETWGPVKEGIATASIAG FT SIVDAPVNLWGTAVLSPIPESGGSRMTLQVTIQVRIPFIGGKLERLIGTQLSQLVTIEQ FT RFTTLWITNNV" FT CDS 228502..229611 FT /transl_table=11 FT /gene="murB" FT /locus_tag="Mb0492" FT /product="PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE FT REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE)" FT /EC_number="1.1.1.158" FT /note="Mb0492, murB, len: 369 aa. Equivalent to Rv0482, FT len: 369 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 369 aa overlap). Probable murB, FT UDP-N-acetylenolpyruvoylglucosamine reductase (EC FT 1.1.1.158), equivalent to CAC31964.1|AL583925 FT UDP-N-acetylenolpyruvoylglucosamine reductase from FT Mycobacterium leprae (367 aa). Also highly similar to FT others e.g. MURB_ECOLI|P08373 FT UDP-N-acetylenolpyruvoylglucosamine reductase from FT Escherichia coli (342 aa), FASTA scores: opt: 292, E(): FT 6.3e-12, (33.5% identity in 355 aa overlap); etc. BELONGS FT TO THE MURB FAMILY. COFACTOR: FAD." FT /db_xref="GOA:P65461" FT /db_xref="HSSP:2MBR" FT /db_xref="InterPro:IPR006094" FT /db_xref="UniProtKB/Swiss-Prot:P65461" FT /protein_id="CAD93355.1" FT /translation="MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQV FT VAALRHLDSAAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGNLVRAEAGA FT VFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLDRCTGEV FT RWVSARDLRFGYRTSVLKHADGLAVPTVVLEVEFALDPSGRSAPLRYGELIAALNATSG FT ERADPQAVREAVLALRARKGMVLDPTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKD FT GPVPHYPAPDGVKLAAGWLVERAGFGKGYPDAGAAPCRLSTKHALALTNRGGATAEDVV FT TLARAVRDGVHDVFGITLKPEPVLIGCML" FT CDS 229673..231028 FT /transl_table=11 FT /gene="lprQ" FT /locus_tag="Mb0493" FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRQ" FT /note="Mb0493, lprQ, len: 451 aa. Equivalent to Rv0483, FT len: 451 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 451 aa overlap). Probable lprQ, FT conserved lipoprotein, equivalent to FT CAC31963.1|AL583925|ML2446 possible lipoprotein from FT Mycobacterium leprae (441 aa); appears longer than ML2446, FT so start may be further downstream. Shows also similarity FT with MLCL383_24|O07707 HYPOTHETICAL 43.6 KD PROTEIN from FT Mycobacterium leprae; and to Q49706|B1496_F2_81 (271 aa). FT Similar to others lipoproteins from other organisms. Also FT similar to several Mycobacterium tuberculosis hypothetical FT proteins e.g. Rv0116c, Rv0192, Rv1433, Rv2518c. Contains FT potential N-terminal signal sequence and appropriately FT positioned PS00013 prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:P64704" FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/Swiss-Prot:P64704" FT /protein_id="CAD93356.1" FT /translation="MVIRVLFRPVSLIPVNNSSTPQSQGPISRRLALTALGFGVLAPNV FT LVACAGKVTKLAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGK FT VVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKAVPVAGKFTTVAPVKTINAGFQ FT LADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDEAQGARVHWRP FT REYYPAGTTVDVDAKLYGLPFGDGAYGAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAG FT VIMDFPCSYGEADLARNVTRNGIHVVTEKYSDFYMSNPAAGYSHIHERWAVRISNNGEF FT IHANPMSAGAQGNSNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYADGDIWD FT WAVDWDTWVSMSALPPPAAKPAATQIPVTAPVTPSDAPTPSGTPTTTNGPGG" FT CDS complement(231009..231764) FT /transl_table=11 FT /gene="Mb0494c" FT /locus_tag="Mb0494c" FT /product="PUTATIVE SHORT-CHAIN TYPE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0494c, -, len: 251 aa. Equivalent to Rv0484c, len: FT 251 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 251 aa overlap). Probable short-chain FT oxidoreductase (EC 1.-.-.-), highly similar to others e.g. FT T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase FT from Streptomyces coelicolor (260 aa); FT YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR FT family) from Haemophilus influenzae (252 aa), FASTA scores: FT opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa FT overlap); etc. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY. STRONG SIMILARITY, FT TO BACTERIAL YDFG HOMOLOGS." FT /db_xref="GOA:Q7U1W7" FT /db_xref="HSSP:1FDU" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U1W7" FT /protein_id="CAD93357.1" FT /translation="MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRI FT TALANQIGGTAIVADVTDDAAVEALARALSRVDVLVNNAGGAKGLQFVADADLEHWRWM FT WDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAALEVYDGGAGYTAAKHAQGALHRTL FT RGELLGKPVRLTEIAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVAT FT RPSHVNLDQIVIRPRDQASASRRATHPVR" FT CDS 231947..233263 FT /transl_table=11 FT /gene="Mb0495" FT /locus_tag="Mb0495" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0495, -, len: 438 aa. Equivalent to Rv0485, len: FT 438 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 438 aa overlap). Possible FT transcriptional repressor, member of the NAGC/XYLR FT repressor FAMILY; similar to several e.g. FT D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor FT from Vibrio cholerae (404 aa), FASTA scores: opt: 378, E(): FT 1.2e-17, (26.9% identity in 350 aa overlap); FT NAGC_ECOLI|P15301 N-acetylglucosamine repressor from FT Escherichia coli (406 aa), FASTA scores: opt: 305, E(): FT 1.8e-12, (21.8% identity in 357 aa overlap); etc." FT /db_xref="InterPro:IPR000600" FT /db_xref="UniProtKB/Swiss-Prot:P64706" FT /protein_id="CAD93358.1" FT /translation="MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAAASVFRA FT VRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAVSGAIGRPRVPVEVNH FT EPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTPRNAAGAALTSLADSADRYLQRWRR FT RRALWVGVTLGGAVDSATGHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMAGAEL FT MLGMRRFAPSSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLGGTGQL FT ESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQQAKELLAERARV FT LGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAFTAGSVLAPRDIRVTVFGNRVQ FT EAGAGIVSLSGLYADPLGALRRSGALDARLQDTAPEALA" FT CDS 233311..234753 FT /transl_table=11 FT /gene="Mb0496" FT /locus_tag="Mb0496" FT /product="MANNOSYLTRANSFERASE" FT /EC_number="2.4.1.-" FT /note="Mb0496, -, len: 480 aa. Equivalent to Rv0486, len: FT 480 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 480 aa overlap). Mannosyltransferase FT (EC 2.4.1.-) (see citations below), highly similar to FT P54138|Y486_MYCLE|ML2443 possible glycosyl transferase from FT Mycobacterium leprae (428 aa); and S72892|B2168_C2_201 FT probable hexosyltransferase (EC 2.4.1.-) from Mycobacterium FT leprae (409 aa), FASTA scores: opt: 2375, E(): 0, (86.4% FT identity in 413 aa overlap). Also highly similar to FT CAC04040.1|AL391406 putative transferase from Streptomyces FT coelicolor (496 aa); and similar to various transferases FT e.g. NP_437172.1|NC_003078 putative membrane-anchored FT glycosyltransferase protein from Sinorhizobium meliloti FT (416 aa); O26550|U67601_1 LPS BIOSYNTHESIS RELATED PROTEIN FT from Methanococcus jannaschii (411 aa), FASTA score: (25.3% FT identity in 387 aa overlap); etc. Also similar to FT CAC87824.1|AJ316594 putative sucrose-phosphate synthase FT from Nostoc punctiforme (422 aa). Contains PS00039 DEAD-box FT subfamily ATP-dependent helicases signature." FT /db_xref="GOA:P64708" FT /db_xref="InterPro:IPR017814" FT /db_xref="UniProtKB/Swiss-Prot:P64708" FT /protein_id="CAD93359.1" FT /translation="MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPR FT RVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVRVA FT PGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQVGW FT LARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEAR FT QVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPD FT IVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLF FT RAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQWA FT DAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNAERQRRGGE FT VISDLVAVGKPRHWTPRRGVGA" FT CDS 234750..235301 FT /transl_table=11 FT /gene="Mb0497" FT /locus_tag="Mb0497" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0497, -, len: 183 aa. Equivalent to Rv0487, len: FT 183 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 183 aa overlap). Conserved hypothetical FT protein, highly similar to FT P54139|Y487_MYCLE|U00018_38|ML2442 HYPOTHETICAL 20.8 KDA FT PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: FT opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa FT overlap). Also highly similar to CAC04041.1|AL391406 FT conserved hypothetical protein from Streptomyces coelicolor FT (168 aa)." FT /db_xref="InterPro:IPR019706" FT /db_xref="UniProtKB/Swiss-Prot:P64710" FT /protein_id="CAD93360.1" FT /translation="MTSSLPTVQRVIQNALEVSQLKYSQHPRPGGAPPALIVELPGERK FT LKINTILSVGEHSVRVEAFVCRKPDENREDVYRFLLRRNRRLYGVAYTLDNVGDIYLVG FT QMALSAVDADEVDRVLGQVLEVVDSDFNALLELGFRSSIQREWQWRLSRGESLQNLQAF FT AHLRPTTMQSAQRDEKELGG" FT CDS 235685..236290 FT /transl_table=11 FT /gene="Mb0498" FT /locus_tag="Mb0498" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0498, -, len: 201 aa. Equivalent to Rv0488, len: FT 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 201 aa overlap). Probable conserved FT integral membrane protein, LysE family possibly involved in FT transport of Lysine, similar to others and conserved FT hypothetical proteins e.g. AB93746.1|AL357613 putative FT membrane transport protein from Streptomyces coelicolor FT (204 aa); D83100|PA4365 probable transporter from FT Pseudomonas aeruginosa (200 aa); YGGA_ECOLI|P11667 FT hypothetical 21.7 kd protein from Escherichia coli (197 FT aa), FASTA scores: opt: 382, E(): 1.1e-19, (39.1% identity FT in 179 aa overlap); CGLYSEG_2 C|P94633 LYSINE EXPORTER FT PROTEIN (236 aa), FASTA scores: E(): 2.3e-07, (33.3% FT identity in 219 aa overlap). Also similar to Rv1986 from FT Mycobacterium tuberculosis." FT /db_xref="GOA:P64712" FT /db_xref="InterPro:IPR001123" FT /db_xref="UniProtKB/Swiss-Prot:P64712" FT /protein_id="CAD93361.1" FT /translation="MMTLKVAIGPQNAFVLRQGIRREYVLVIVALCGIADGALIAAGVG FT GFAALIHAHPNMTLVARFGGAAFLIGYALLAARNAWRPSGLVPSESGPAALIGVVQMCL FT VVTFLNPHVYLDTVVLIGALANEESDLRWFFGAGAWAASVVWFAVLGFSAGRLQPFFAT FT PAAWRILDALVAVTMIGVAVVVLVTSPSVPTANVALII" FT CDS 236447..237196 FT /transl_table=11 FT /gene="gpm1" FT /locus_tag="Mb0499" FT /product="PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 FT (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)" FT /EC_number="5.4.2.1" FT /note="Mb0499, gpm1, len: 249 aa. Equivalent to Rv0489, FT len: 249 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 249 aa overlap). Probable gpm1, FT phosphoglycerate mutase 1 (EC 5.4.2.1), equivalent to FT P53531|PMGY_MYCLE PHOSPHOGLYCERATE MUTASE from FT Mycobacterium leprae (247 aa). Also highly similar to FT others e.g. PMG1_ECOLI|P31217 (249 aa), FASTA scores: opt: FT 805, E(): 0, (51.4% identity in 245 aa overlap); etc. FT Contains PS00175 Phosphoglycerate mutase family FT phosphohistidine signature, and PS00017 ATP/GTP-binding FT site motif A (P-loop). BELONGS TO THE PHOSPHOGLYCERATE FT MUTASE FAMILY. Note that previously known as gpm." FT /db_xref="GOA:P0A5R7" FT /db_xref="HSSP:1QHF" FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/Swiss-Prot:P0A5R7" FT /protein_id="CAD93362.1" FT /translation="MANTGSLVLLRHGESDWNALNLFTGWVDVGLTDKGQAEAVRSGEL FT IAEHDLLPDVLYTSLLRRAITTAHLALDSADRLWIPVRRSWRLNERHYGALQGLDKAET FT KARYGEEQFMAWRRSYDTPPPPIERGSQFSQDADPRYADIGGGPLTECLADVVARFLPY FT FTDVIVGDLRVGKTVLIVAHGNSLRALVKHLDQMSDDEIVGLNIPTGIPLRYDLDSAMR FT PLVRGGTYLDPEAAAAGAAAVAGQGRG" FT CDS 237370..238602 FT /transl_table=11 FT /gene="senX3" FT /locus_tag="Mb0500" FT /product="PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE FT SENX3" FT /EC_number="2.7.3.-" FT /note="Mb0500, senX3, len: 410 aa. Equivalent to Rv0490, FT len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 410 aa overlap). Putative senX3, FT two-component sensor histidine kinase (EC 2.7.3.-), FT transmembrane protein (see citations below), equivalent to FT O07129|SEX3_MYCBO SENSOR-LIKE HISTIDINE KINASE SENX3 from FT Mycobacterium bovis BCG (410 aa), FASTA scores: E(): 0, FT (99.5% identity in 410 aa overlap); and highly similar to FT P54883|SEX3_MYCLE|SENX3 SENSOR-LIKE HISTIDINE KINASE from FT Mycobacterium leprae (443 aa), FASTA score: (83.8% identity FT in 408 aa overlap). Also highly similar, except in FT N-terminus, to CAC31957.1|AL583925 probable two-component FT system sensor histidine kinase from Mycobacterium leprae FT (441 aa). Also highly similar to sensor kinase proteins FT from other organisms e.g. CAB77323.1|AL160331 putative FT sensor kinase protein from Streptomyces coelicolor (426 FT aa)." FT /db_xref="GOA:P0A601" FT /db_xref="InterPro:IPR005467" FT /db_xref="UniProtKB/Swiss-Prot:P0A601" FT /protein_id="CAD93363.1" FT /translation="MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSG FT ITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGG FT EDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVA FT NVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQG FT AERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLV FT SNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATG FT GSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRS FT NRSQREEELSR" FT CDS 238960..239643 FT /transl_table=11 FT /gene="regX3" FT /locus_tag="Mb0501" FT /product="TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 FT (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY FT LUXR-FAMILY)" FT /note="Mb0501, regX3, len: 227 aa. Equivalent to Rv0491, FT len: 227 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 227 aa overlap). regX3, response FT regulator protein (sensory transduction protein) (see FT citations below), equivalent to O07130|RGX3_MYCBO|REGX3 FT SENSORY TRANSDUCTION PROTEIN from Mycobacterium bovis BCG FT (227 aa); AAG09797.1|AF258346_2|AF258346|REGX3 response FT regulator from Mycobacterium smegmatis (228 aa); equivalent FT to P54884|RGX3_MYCLE|REGX3 SENSORY TRANSDUCTION PROTEIN FT from Mycobacterium leprae (198 aa), FASTA scores : E(): 0, FT (95.4% identity in 197 aa overlap). Also highly similar to FT other response regulators e.g. AAG43239.1|AF123314_2 FT |AF123314 putative response regulator from Corynebacterium FT glutamicum (232 aa)." FT /db_xref="GOA:O07130" FT /db_xref="HSSP:1MVO" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:O07130" FT /protein_id="CAD93364.1" FT /translation="MTSVLIVEDEESLADPLAFLLRKEGFEATVVTDGPAALAEFDRAG FT ADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVTKPYS FT ARELIARIRAVLRRGGDDDSEMSDGVLESGPVRMDVERHVVSVNGDTITLPLKEFDLLE FT YLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLG FT YKLEG" FT CDS complement(239640..241529) FT /transl_table=11 FT /gene="Mb0502c" FT /locus_tag="Mb0502c" FT /product="PROBABLE OXIDOREDUCTASE GMC-TYPE" FT /EC_number="1.-.-.-" FT /note="Mb0502c, -, len: 629 aa. Equivalent to Rv0492c, len: FT 629 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 629 aa overlap). Probable oxidoreductase FT GMC type (EC 1.-.-.-), similar to others except in FT N-terminus e.g. P55582|AE000087_5|Y4NJ_RHISN HYPOTHETICAL FT GMC-TYPE OXIDOREDUCTASE from Rhizobium sp. (505 aa), FASTA FT scores: opt: 873, E():0, (34.3% identity in 502 aa FT overlap); YTH2_RHOER|P46371 HYPOTHETICAL 53.0 kd GMC-TYPE FT OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa), FT FASTA score: (25.7% identity in 521 aa overlap); FT YTH2_RHOSO|P46371 hypothetical 53.0 kd gmc-type FT oxidoreductase from Rhodococcus erythropolis (493 aa), FT FASTA score: (25.7% identity in 521 aa overlap); FT NP_085596.1|NC_002679 probable oxidoreductase from FT Mesorhizobium loti (507 aa); NP_285451.1|NC_001264 GMC FT oxidoreductase from Deinococcus radiodurans (722 aa); FT NP_249055.1|NC_002516 probable oxidoreductase from FT Pseudomonas aeruginosa (531 aa); etc. Contains PS00198 FT 4Fe-4S ferredoxins, iron-sulfur binding region signature, FT and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE FT GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD (BY SIMILARITY). FT Note that start changed since first submission (previously FT 684 aa)." FT /db_xref="GOA:Q7U1W6" FT /db_xref="InterPro:IPR003953" FT /db_xref="UniProtKB/TrEMBL:Q7U1W6" FT /protein_id="CAD93365.1" FT /translation="MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLP FT ATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERARVLHRIAALSPEVAAAVEGLKAIV FT LLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAMVAR FT TLARAGLDVVVLEEGRRWTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMGRAVG FT GTTVVNSGTCFRPSLAVQRRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRN FT GRLLLQAAKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGARII FT SWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSGLGGHPRL FT GHNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESDGVLIEATSTPPGMGSMVFPG FT YGAELLRWLDRAPQIATFGAMVADRGVGTVRSVRGETVVRYDIAPGEIAKLRVALQAIG FT RLFFAAGAVEVLTGIPGAPPMRSLPELQDVLRRANPRSLHLAAFHPTGTAAAGADEQLC FT PVDATGRLRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR" FT CDS complement(241526..241855) FT /transl_table=11 FT /gene="Mb0503c" FT /locus_tag="Mb0503c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0503c, -, len: 109 aa. Equivalent to Rv0492A, len: FT 109 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 109 aa overlap). Hypothetical unknown FT protein. GC plot suggests CDS." FT /db_xref="UniProtKB/TrEMBL:Q7U1W5" FT /protein_id="CAD93366.1" FT /translation="MSFLLDPPLLFVCGVLIERRLPVDRRDAAEAAALGVFFGASFGLY FT HNVPGLGMLWRPFRAQNGRDFMWNSGVFSVDVARAEWPLHAMAAAIFATYPFFIKLGRR FT LGRRI" FT CDS complement(241852..242841) FT /transl_table=11 FT /gene="Mb0504c" FT /locus_tag="Mb0504c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0504c, -, len: 329 aa. Equivalent to Rv0493c, len: FT 329 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 329 aa overlap). Conserved hypothetical FT protein, showing some similarity to U00018_33|B2168_F2_93 FT from Mycobacterium leprae (167 aa), FASTA scores: opt: 166, FT E(): 0.00077, (35.9% identity in 131 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U1W4" FT /protein_id="CAD93367.1" FT /translation="MGESTTQPAGGAAVDDETRSAALPRWRGAAGRLEVWYATLSDPLT FT RTGLWVHCETVAPTTGGPYAHGWVTWFPPDAPPGTERFGPQPAQPAAGPAWFDIAGVRM FT APAELTGRTRSLAWELSWKDTAAPLWTFPRVAWERELLPGAQVVIAPTAVFAGSLAVGE FT TTHRVDSWRGGVAHIYGHGNAKRWGWIHADLGDGDVLEVVTAVSHKPGLRRLAPLAFVR FT FRIDGKDWPASPLPSLRMRTTLGVRHWQLEGRIGGREALIRVDQPPERCVSLGYTDPDG FT AKAVCTNTEQADIHIELGGRHWSVLGTGHAEVGLRGTAAPAIKEGTPA" FT CDS 242846..243574 FT /transl_table=11 FT /gene="Mb0505" FT /locus_tag="Mb0505" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT /note="Mb0505, -, len: 242 aa. Equivalent to Rv0494, len: FT 242 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 242 aa overlap). Probable FT transcriptional regulator, GntR family, with C-terminal FT part highly similar to S72893|B2168_C2_205 hypothetical FT protein from Mycobacterium leprae (105 aa). Also similar to FT other transcription regulators e.g. PDHR_ECOLI|P06957 FT pyruvate dehydrogenase complex repressor PDHR or GENA from FT Escherichia coli (254 aa), FASTA scores: opt: 284, E(): FT 1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains FT PS00043 Bacterial regulatory proteins, gntR family FT signature, and probable helix-turn helix motif from aa FT 50-71 (Score 1229, +3.37 SD)." FT /db_xref="GOA:P67740" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67740" FT /protein_id="CAD93368.1" FT /translation="MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPE FT RDLAERLGVNRTSLRQGLARLQQMGLIEVRHGSGSVVRDPEGLTHPAVVEALVRKLGPD FT FLVELLEIRAALGPLIGRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYFRVL FT IHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAAAAAT FT VEAYLNASALRMVKSYRDRA" FT CDS complement(243575..244465) FT /transl_table=11 FT /gene="Mb0506c" FT /locus_tag="Mb0506c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0506c, -, len: 296 aa. Equivalent to Rv0495c, len: FT 296 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 296 aa overlap). Conserved hypothetical FT protein, highly similar to S72915|B2168_F1_37 hypothetical FT protein from Mycobacterium leprae (323 aa), FASTA scores: FT opt: 1615, E(): 0, (82.7% identity in 271 aa overlap); and FT P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925 FT conserved hypothetical protein from Mycobacterium leprae FT (277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16 FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (271 FT aa)." FT /db_xref="UniProtKB/Swiss-Prot:P64714" FT /protein_id="CAD93369.1" FT /translation="MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPGQ FT EVELDFAREWVEFYDPDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCSHG FT AFLSDDDDRTRLADAVHKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGACIF FT LNRPGFAGGAGCALHSKALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILKTTLT FT EYDRRGWGSGGADLHWYCTGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAMCKRRS FT QLGLIAVHPATRAAQ" FT CDS 244545..245531 FT /transl_table=11 FT /gene="Mb0507" FT /locus_tag="Mb0507" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0507, -, len: 328 aa. Equivalent to Rv0496, len: FT 328 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 328 aa overlap). Conserved hypothetical FT protein, highly similar to S72894|467046|AAA17230.1|U00018 FT exopolyphosphatase (EC 3.6.1.11) ppx from Mycobacterium FT leprae (406 aa), FASTA scores: opt: 1902, E(): 0, (86.6% FT identity in 343 aa overlap); and FT P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925 FT HYPOTHETICAL 36.2 KDA PROTEIN from Mycobacterium leprae FT (339 aa). Also highly similar to hypothetical proteins and FT exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c FT HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa). FT C-terminal region similar to CGU31224_1|Q46054 protein FT similar to ppx gene product of Mycobacterium leprae from FT Cornybacterium glutamicum (140 aa), FASTA scores: opt: 615, FT E(): 2.7e-33, (70.9% identity in 134 aa overlap)." FT /db_xref="GOA:P65787" FT /db_xref="InterPro:IPR003695" FT /db_xref="UniProtKB/Swiss-Prot:P65787" FT /protein_id="CAD93370.1" FT /translation="MVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTID FT EFAKIAISSGCAELMAFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFLAV FT RRWYGWSAGRILNLDIGGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGRRRV FT AMLRDWLDAELAEPSVTVLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRTLTAN FT GLRQLIAFISRMTAVDRAELEGVSADRAPQIVAGALVAEASMRALSIEAVEICPWALRE FT GLILRKLDSEADGTALIESSSVHTSVRAVGGQPADRNAANRSRGSKP" FT CDS 245528..246460 FT /transl_table=11 FT /gene="Mb0508" FT /locus_tag="Mb0508" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0508, -, len: 310 aa. Equivalent to Rv0497, len: FT 310 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 310 aa overlap). Probable conserved FT transmembrane protein, equivalent (but shorter in FT C-terminus) to P54580|Y497_MYCLE|ML2433 HYPOTHETICAL 37.9 FT KDA PROTEIN from Mycobacterium leprae (355 aa). N-terminus FT highly similar to S72922|B2168_C1_166|467074 hypothetical FT protein from Mycobacterium leprae (118 aa), FASTA scores: FT opt: 350, E(): 1.4e-12, (57.9% identity in 114 aa overlap); FT and hydrophobic C-terminus, highly similar to FT S72895|B2168_C2_209|467047 hypothetical protein from FT Mycobacterium leprae (241 aa), FASTA scores: opt: 473, E(): FT 8e-19, (53.9% identity in 241 aa)." FT /db_xref="GOA:P64716" FT /db_xref="UniProtKB/Swiss-Prot:P64716" FT /protein_id="CAD93371.1" FT /translation="MTGPHPETESSGNRQISVAELLARQGVTGAPARRRRRRRGDSDAI FT TVAELTGEIPIIRDDHHHAGPDAHASQSPAANGRVQVGEAAPQSPAEPVAEQVAEEPTR FT TVYWSQPEPRWPKSPPQDRRESGPELSEYPRPLRHTHSDRAPAGPPSGAEHMSPDPVEH FT YPDLWVDVLDTEVGEAEAETEVREAQPGRGERHAAAAAAGTDVEGDGAAEARVARRALD FT VVPTLWRGALVVLQSILAVAFGAGLFIAFDQLWRWNSIVALVLSVMVILGLVVSVRAVR FT KTEDIASTLIAVAVGALITLGPLALLQSG" FT CDS 246476..247318 FT /transl_table=11 FT /gene="Mb0509" FT /locus_tag="Mb0509" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0509, -, len: 280 aa. Equivalent to Rv0498, len: FT 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 280 aa overlap). Conserved hypothetical FT protein, highly similar to P54581|Y498_MYCLE|ML2432 FT HYPOTHETICAL 30.5 KDA PROTEIN from Mycobacterium leprae FT (280 aa); and S72896|B2168_C2_210 hypothetical protein from FT Mycobacterium leprae (244 aa), FASTA scores: opt: 1486, FT E():0, (89.3% identity in 244 aa overlap). Also similar to FT Q9X8H0|Y714_STRCO|SCE7.14c HYPOTHETICAL PROTEIN from FT Streptomyces coelicolor." FT /db_xref="InterPro:IPR012307" FT /db_xref="UniProtKB/Swiss-Prot:P64718" FT /protein_id="CAD93372.1" FT /translation="MRPAIKVGLSTASVYPLRAEAAFEYADRLGYDGVELMVWGESVSQ FT DIDAVRKLSRRYRVPVLSVHAPCLLISQRVWGANPILKLDRSVRAAEQLGAQTVVVHPP FT FRWQRRYAEGFSDQVAALEAASTVMVAVENMFPFRADRFFGAGQSRERMRKRGGGPGPA FT ISAFAPSYDPLDGNHAHYTLDLSHTATAGTDSLDMARRMGPGLVHLHLCDGSGLPADEH FT LVPGRGTQPTAEVCQMLAGSGFVGHVVLEVSTSSARSANERESMLAESLQFARTHLLR" FT CDS 247334..248209 FT /transl_table=11 FT /gene="Mb0510" FT /locus_tag="Mb0510" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0510, -, len: 291 aa. Equivalent to Rv0499, len: FT 291 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 291 aa overlap). Conserved hypothetical FT protein, showing some similarity to FT AL031184|SC2A11_16|T34762 hypothetical protein from FT Streptomyces coelicolor (340 aa), FASTA scores: opt: 240, FT E(): 1.8e-07, (28.9% identity in 270 aa overlap)." FT /db_xref="GOA:P64720" FT /db_xref="InterPro:IPR001206" FT /db_xref="UniProtKB/Swiss-Prot:P64720" FT /protein_id="CAD93373.1" FT /translation="MNALFTTAMALRPLDSDPGNPACRVFEGELNEHWTIGPKVHGGAM FT VALCANAARTAYGAAGQQPMRQPVAVSASFLWAPDPGTMRLVTSIRKRGRRISVADVEL FT TQGGRTAVHAVVTLGEPEHFLPGVDGSGGASGTAPLLSANPVVELMAPEPPEGVVPIGP FT GHQLAGLVHLGEGCDVRPVLSTLRSATDGRPPVIQLWARPRGVAPDALFALLCGDLSAP FT VTFAVDRTGWAPTVALTAYLRALPADGWLRVLCTCVEIGQDWFDEDHIVVDRLGRIVVQ FT TRQLAMVPAQ" FT CDS 248234..249121 FT /transl_table=11 FT /gene="proC" FT /locus_tag="Mb0511" FT /product="PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC FT (P5CR) (P5C REDUCTASE)" FT /EC_number="1.5.1.2" FT /note="Mb0511, proC, len: 295 aa. Equivalent to Rv0500, FT len: 295 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 295 aa overlap). Probable proC, FT Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (see FT citation below), equivalent to P46725|PROC_MYCLE FT PYRROLINE-5-CARBOXYLATE REDUCTASE from Mycobacterium leprae FT (294 aa), FASTA scores: opt: 1473, E(): 0, (82.4% identity FT in 295 aa overlap). Also similar to others e.g. FT P46540|PROC_CORGL PYRROLINE-5-CARBOXYLATE REDUCTASE from FT Corynebacterium glutamicum (270 aa); FT T36286|4803683|CAB42663.1|AL049819 pyrroline-5-carboxylate FT reductase from Streptomyces coelicolor (284 aa); etc. FT BELONGS TO THE PYRROLINE-5-CARBOXYLATE REDUCTASE FAMILY." FT /db_xref="GOA:Q7U1W3" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U1W3" FT /protein_id="CAD93374.1" FT /translation="MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRAN FT YLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVV FT AGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGG FT VLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAML FT LERMDQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQ FT AAKSRSEQLRITPE" FT CDS 249262..249498 FT /transl_table=11 FT /gene="Mb0512" FT /locus_tag="Mb0512" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0512, -, len: 78 aa. Equivalent to Rv0500A, len: FT 78 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 78 aa overlap). Conserved hypothetical FT protein, similar to proteins from Mycobacterium leprae and FT Streptomyces coelicolor e.g. U00018_25 from Mycobacterium FT leprae cosmid B2168 (86 aa), FASTA scores: opt: 428, E(): FT 1.3e-27, (82.6% identity in 86 aa overlap); FT AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 FT (70 aa), FASTA scores: opt: 252, E(): 1.2 e-13, (72.2 FT identity in 54 aa overlap)." FT /db_xref="GOA:Q7U1W2" FT /db_xref="InterPro:IPR010093" FT /db_xref="UniProtKB/TrEMBL:Q7U1W2" FT /protein_id="CAD93375.1" FT /translation="MTSTNGPSARDTGFVEGQQAKTQLLTVAEVAALMRVSKMTVYRLV FT HNGELPAVRVGRSFRVHAKAVHDMLETSYFDAG" FT CDS 249805..250935 FT /transl_table=11 FT /gene="galE2" FT /locus_tag="Mb0513" FT /product="POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 FT (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE FT DIPHOSPHATE GALACTOSE 4-EPIMERASE) (URIDINE FT DIPHOSPHO-GALACTOSE 4-EPIMERASE)" FT /EC_number="5.1.3.2" FT /note="Mb0513, galE2, len: 376 aa. Equivalent to Rv0501, FT len: 376 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 376 aa overlap). Possible galE2, FT UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar FT (except in N-terminus) to CAC31944.1|AL583925 possible FT glucose epimerase/dehydratase from Mycobacterium leprae FT (364 aa). N-terminus highly similar to FT S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical FT protein from Mycobacterium leprae (180 aa), FASTA scores: FT opt: 934, E(): 0, (89.6% identity in 164 aa overlap); and FT C-terminus highly similar to FT S72898|467050|AAA17234.1|U00018 hypothetical protein from FT Mycobacterium leprae (168 aa), FASTA scores: opt: 928, E(): FT 0, (82.7% identity in 168 aa overlap). Also highly similar FT to T36274|5123671|CAB45360.1|AL079345 probable epimerase FT from Streptomyces coelicolor (353 aa); and similar in part FT to other epimerases e.g. GALE_ECOLI|P09147 UDP-glucose FT 4-epimerase from Escherichia coli (338 aa), FASTA scores: FT opt: 241, E(): 6.7e-09, (28.2% identity in 294 aa overlap); FT etc. BELONGS TO THE SUGAR EPIMERASE FAMILY. COFACTOR: NAD. FT Note that previously known as galE1." FT /db_xref="GOA:P0A5D2" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P0A5D2" FT /protein_id="CAD93376.1" FT /translation="MSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLAQ FT NPLINRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAASYA FT PRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDSSSR FT RPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPLVPTI FT FGRDARLQLLHEQDALGALERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVPVPGFG FT VWALDSLRRANHYTELNREQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRG FT LTPIIDPHRVRSWEGRAVGLAQRWGSRNPIPWSGLR" FT CDS 250942..252018 FT /transl_table=11 FT /gene="Mb0514" FT /locus_tag="Mb0514" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0514, -, len: 358 aa. Equivalent to Rv0502, len: FT 358 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 358 aa overlap). Conserved hypothetical FT protein, equivalent to P54878|Y502_MYCLE|ML2427 FT HYPOTHETICAL 40.5 KDA PROTEIN from Mycobacterium leprae FT (367 aa), FASTA scores: opt: 2042, E(): 0, (84.1% identity FT in 365 aa overlap). Also similar to T36273|SCE68.23c FT hypothetical protein from Streptomyces coelicolor (355 aa). FT C-terminal similar to AL021529|SC10A5_4|T34572 hypothetical FT protein from Streptomyces coelicolor (295 aa), FASTA score: FT (57.8% identity in 263 aa overlap); and to hypothetical FT proteins from Mycobacterium tuberculosis Rv1920|G70808 (287 FT aa); and Rv1428c|G70914 (275 aa)." FT /db_xref="GOA:P64724" FT /db_xref="InterPro:IPR016676" FT /db_xref="UniProtKB/Swiss-Prot:P64724" FT /protein_id="CAD93377.1" FT /translation="MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDPN FT DRASAEQIAAVVREIDEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSVDE FT FGFDPHFNSAIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLMLSV FT AVHDEHPAHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAVFPEG FT YKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLLARLFG FT LPYFPITPLFPLAGPVGLVPLPSKWRIAFGEPICTADYASTDADDPMVTFELTDQVRET FT IQQTLYRLLAGRRNIFFG" FT CDS complement(252022..252930) FT /transl_table=11 FT /gene="cmaA2" FT /locus_tag="Mb0515c" FT /product="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 FT CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) FT (CYCLOPROPANE MYCOLIC ACID SYNTHASE 2) (MYCOLIC ACID FT TRANS-CYCLOPROPANE SYNTHETASE)" FT /EC_number="2.1.1.79" FT /note="Mb0515c, cmaA2, len: 302 aa. Equivalent to Rv0503c, FT len: 302 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 302 aa overlap). cmaA2 (alternate gene FT name: cma2), cyclopropane-fatty-acyl-phospholipid synthase FT 2 (mycolic acid trans-cyclopropane synthetase) (EC FT 2.1.1.79) (see citations below). Note that this protein has FT 302 aa and not 322 aa: we have chosen a different FT initiation codon on the basis of homology). Equivalent to FT S72886|B2168_F3_130 hypothetical protein from Mycobacterium FT leprae (308 aa), FASTA score: (78.9% identity in 303 aa FT overlap); and highly similar to other proteins from FT Mycobacterium leprae. Also similar to other proteins from FT Mycobacterium tuberculosis and Mycobacterium bovis BCG e.g. FT MTV038_14|UMAA2|Rv0470c|MTV038.14 PUTATIVE MYCOLIC ACID FT SYNTHESIS/MODIFICATION PROTEIN (287 aa) (57.2% identity in FT 297 aa overlap)." FT /db_xref="GOA:P0A5P1" FT /db_xref="InterPro:IPR003333" FT /db_xref="UniProtKB/Swiss-Prot:P0A5P1" FT /protein_id="CAD93378.1" FT /translation="MTSQGDTTSGTQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCAY FT FERPDMTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEYDVNVIGLTLS FT ENQYAHDKAMFDEVDSPRRKEVRIQGWEEFDEPVDRIVSLGAFEHFADGAGDAGFERYD FT TFFKKFYNLTPDDGRMLLHTITIPDKEEAQELGLTSPMSLLRFIKFILTEIFPGGRLPR FT ISQVDYYSSNAGWKVERYHRIGANYVPTLNAWADALQAHKDEAIALKGQETYDIYMHYL FT RGCSDLFRDKYTDVCQFTLVK" FT CDS complement(252953..253453) FT /transl_table=11 FT /gene="Mb0516c" FT /locus_tag="Mb0516c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0516c, -, len: 166 aa. Equivalent to Rv0504c, len: FT 166 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 166 aa overlap). Conserved hypothetical FT protein, equivalent to P54879|Y504_MYCLE|ML2425 FT HYPOTHETICAL 18.7 KDA PROTEIN from Mycobacterium leprae FT (166 aa), FASTA scores: opt: 884, E(): 0, (83.1% identity FT in 166 aa overlap); and highly similar to other proteins FT from Mycobacterium leprae. Also highly similar to FT CAB77410.1|AL160431|SCD82.07 hypothetical protein from FT Streptomyces coelicolor (150 aa). Also similar to M. FT tuberculosis hypothetical proteins Rv0635|H70612 (158 aa); FT and Rv0637|B70613 (166 aa)." FT /db_xref="InterPro:IPR016709" FT /db_xref="UniProtKB/Swiss-Prot:P64726" FT /protein_id="CAD93379.1" FT /translation="MTVPEEAQTLIGKHYRAPDHFLVGREKIREFAVAVKDDHPTHYSE FT PDAAAAGYPALVAPLTFLAIAGRRVQLEIFTKFNIPINIARVFHRDQKFRFHRPILAND FT KLYFDTYLDSVIESHGTVLAEIRSEVTDAEGKPVVTSVVTMLGEAAHHEADADATVAAI FT ASI" FT CDS complement(253615..254736) FT /transl_table=11 FT /gene="serB1" FT /locus_tag="Mb0517c" FT /product="POSSIBLE PHOSPHOSERINE PHOSPHATASE SERB1 (PSP) FT (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSPASE)" FT /EC_number="3.1.3.3" FT /note="Mb0517c, serB1, len: 373 aa. Equivalent to Rv0505c, FT len: 373 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 373 aa overlap). Possible serB1, FT phosphoserine phosphatase (EC 3.1.3.3), equivalent (but FT longer ~70 aa in N-terminus) to S72914|serB phosphoserine FT phosphatase from Mycobacterium leprae (300 aa), FASTA FT scores: opt: 1570, E(): 0, (83.0% identity in 306 aa FT overlap). C-terminus highly similar to CAB55344.1|AJ010584 FT phosphoserine phosphatase from Streptomyces coelicolor (266 FT aa). Low similarity to SERB_ECOLI|P06862 phosphoserine FT phosphatase from Escherichia coli strains K12 and O157:H7 FT (322 aa), FASTA scores: opt: 148, E(): 0.043, (24.0% FT identity in 150 aa overlap). C-terminus is also similar to FT O33611|AB004855_1|IMD_STRCN PROTEIN INVOLVED IN INHIBITION FT OF MORPHOLOGICAL DIFFERENTIATION from Streptomyces cyaneus FT (277 aa), FASTA score: (37.7% identity in 252 aa overlap). FT SEEMS TO BELONG TO THE SERB FAMILY. Note that previously FT known as serB." FT /db_xref="GOA:P66802" FT /db_xref="InterPro:IPR006385" FT /db_xref="UniProtKB/Swiss-Prot:P66802" FT /protein_id="CAD93380.1" FT /translation="MGLTCWPRTAAGRVHDESRCGLANFDTALGLQINPRQPRAPPRIC FT RIGLITAAASATGQAPRLGVMMVSSHLGSPDQAGHVDLASPADPPPPDASASHSPVDMP FT APVAAAGSDRQPPIDLTAAAFFDVDNTLVQGSSAVHFGRGLAARHYFTYRDVLGFLYAQ FT AKFQLLGKENSNDVAAGRRKALAFIEGRSVAELVALGEEIYDEIIADKIWDGTRELTQM FT HLDAGQQVWLITATPYELAATIARRLGLTGALGTVAESVDGIFTGRLVGEILHGTGKAH FT AVRSLAIREGLNLKRCTAYSDSYNDVPMLSLVGTAVAINPDARLRSLARERGWEIRDFR FT IARKAARIGVPSALALGAAGGALAALASRRQSR" FT CDS |