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EBI DbfetchID BX248334; SV 1; linear; genomic DNA; STD; PRO; 343050 BP. XX AC BX248334; XX DT 10-JUN-2003 (Rel. 76, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Mycobacterium bovis subsp. bovis AF2122/97 complete genome; segment 1/14 XX KW complete genome. XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. XX RN [1] RX DOI; 10.1073/pnas.1130426100 RX PUBMED; 12788972. RA Garnier T., Eiglmeier K., Camus J.C., Medina N., Mansoor H., Pryor M., RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.; RT "The complete genome sequence of Mycobacterium bovis"; RL Proc. Natl. Acad. Sci. U.S.A. 100(13):7877-7882(2003). XX RN [2] RP 1-343050 RA Garnier T.; RT ; RL Submitted (24-MAR-2003) to the EMBL/GenBank/DDBJ databases. RL Garnier T., Unite de Genetique Moleculaire Bacterienne Institut Pasteur RL 28,rue du Dr Roux 75724 PARIS cedex 15, France. e-mail:tgarnier@pasteur.fr RL Submitted on behalf of the Mycobacterium bovis sequencing teams, TB RL Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New RL Haw,Addlestone, Surrey KT15 3NB, UK. Sanger Centre, Wellcome Trust Genome RL Campus, Hinxton,Cambridge CB10 1SA, UK. PT4 Annotation, Genopole, Institut RL Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. Unite de RL Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur RL Roux, 75724 Paris Cedex 15, France. XX DR EMBL-CON; BX248333. DR RFAM; RF00504; Glycine. XX FH Key Location/Qualifiers FH FT source 1..343050 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT /db_xref="taxon:233413" FT CDS 1..1524 FT /transl_table=11 FT /gene="dnaA" FT /locus_tag="Mb0001" FT /product="CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA" FT /note="Mb0001, dnaA, len: 507 aa. Equivalent to Rv0001, FT len: 507 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 507 aa overlap). dnaA, chromosomal FT replication initiator protein (see citations below), FT equivalent to other Mycobacterial CHROMOSOMAL REPLICATION FT INITIATOR PROTEINS e.g. P46388|DNAA_MYCLE from FT Mycobacterium leprae (502 aa); Q9L7L7|DNAA_MYCPA from FT Mycobacterium paratuberculosis (509 aa); P49990|DNAA_MYCAV FT from Mycobacterium avium (508 aa); P49992|DNAA_MYCSM from FT Mycobacterium smegmatis (504 aa); etc. Also highly similar FT to others except in N-terminus e.g. Q9ZH75|DNAA_STRCH FT CHROMOSOMAL REPLICATION INITIATOR PROTEIN from Streptomyces FT chrysomallus (624 aa); Q9ZH76|DNAA_STRRE from Streptomyces FT reticuli (643 aa); DNAA_ECOLI|P03004|B3702 chromosomal FT replication initiator protein from Escherichia coli strain FT K12 (467 aa), FASTA scores: opt: 986, E(): 0, (43.2% FT identity in 389 aa overlap); etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop) and PS01008 DnaA FT protein signature. BELONGS TO THE DNAA FAMILY. Note that FT the first base of this gene has been taken as base 1 of the FT Mycobacterium bovis genomic sequence." FT /db_xref="GOA:P49991" FT /db_xref="HSSP:1J1V" FT /db_xref="InterPro:IPR013317" FT /db_xref="UniProtKB/Swiss-Prot:P49991" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92863.1" FT /translation="MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQR FT AWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAPPA FT TDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPRNTDSATA FT GVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAAG FT NYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEG FT IQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIA FT ILRKKAQMERLAIPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKALAEIVL FT RDLIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYLCRELTDLS FT LPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR" FT CDS 2052..3260 FT /transl_table=11 FT /gene="dnaN" FT /locus_tag="Mb0002" FT /product="DNA POLYMERASE III (BETA CHAIN) DNAN (DNA FT NUCLEOTIDYLTRANSFERASE)" FT /EC_number="2.7.7.7" FT /note="Mb0002, dnaN, len: 402 aa. Equivalent to Rv0002, FT len: 402 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 402 aa overlap). dnaN, DNA polymerase FT III (beta chain) (EC 2.7.7.7) (see citations below), FT equivalent to other Mycobacterial DNA POLYMERASES III BETA FT CHAIN e.g. NP_301130.1|NC_002677 from Mycobacterium leprae FT (399 aa); Q9L7L6|DP3B_MYCPA from Mycobacterium avium subsp. FT paratuberculosis (399 aa); P52851|DP3B_MYCSM from FT Mycobacterium smegmatis (397 aa); etc. Also highly similar FT to others e.g. P27903|DP3B_STRCO DNA POLYMERASE III BETA FT CHAIN from Streptomyces coelicolor (376 aa), FASTA scores: FT opt: 1189, E(): 0, (52.8% identity in 337 aa overlap); FT P21174|DP3B_MICLU from Micrococcus luteus (310 aa); FT P52023|DP3B_SYNP7 from Synechococcus sp. strain PCC 7942 FT (375 aa); etc. Overlaps and extends CDS in neighbouring FT cosmid MTCY10H4.01." FT /db_xref="GOA:O33914" FT /db_xref="InterPro:IPR001001" FT /db_xref="UniProtKB/Swiss-Prot:O33914" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92864.1" FT /translation="MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGV FT LLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVGVHVEG FT NRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPM FT LTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGS FT DVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELI FT EAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYL FT TDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYVYLLMPVR FT LPG" FT CDS 3280..4437 FT /transl_table=11 FT /gene="recF" FT /locus_tag="Mb0003" FT /product="DNA REPLICATION AND REPAIR PROTEIN RECF FT (SINGLE-STRAND DNA BINDING PROTEIN)" FT /note="Mb0003, recF, len: 385 aa. Equivalent to Rv0003, FT len: 385 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 385 aa overlap). recF, DNA replication FT and repair protein (see citations below), equivalent to FT others Mycobacterial DNA replication and repair proteins FT e.g. NP_301131.1|NC_002677 from Mycobacterium leprae (385 FT aa); Q9L7L5|RECF_MYCPA from Mycobacterium avium subsp. FT paratuberculosis (385 aa); P50916|RECF_MYCSM from FT Mycobacterium smegmatis (384 aa); etc. Also highly similar FT to others e.g. P36176|RECF_STRCO DNA REPLICATION AND REPAIR FT PROTEIN from Streptomyces coelicolor (373 aa); FT NP_440892.1|NC_000911 from Synechocystis sp. strain PCC FT 6803 (384 aa); NP_469352.1|NC_003212 from Listeria innocua FT (370 aa); etc. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop), PS00617 RecF protein signature 1, and PS00618 FT RecF protein signature 2. BELONGS TO THE RECF FAMILY." FT /db_xref="GOA:Q7U314" FT /db_xref="InterPro:IPR003395" FT /db_xref="UniProtKB/Swiss-Prot:Q7U314" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92865.1" FT /translation="MYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALWY FT STTLGSHRVSADLPLIRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSVRS FT TRDVVGVLRAVLFAPEDLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVVRQRTA FT LLKSVPGARYRGDRGVFDTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQLLAPE FT SRSASIGYRASMDVTGPSEQSDTDRQLLAARLLAALAARRDAELERGVCLVGPHRDDLI FT LRLGDQPAKGFASHGEAWSLAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVMRRRALA FT TAAESAEQVLVTAAVLEDIPAGWDARRVHIDVRADDTGSMSVVLP" FT CDS 4434..4997 FT /transl_table=11 FT /gene="Mb0004" FT /locus_tag="Mb0004" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0004, -, len: 187 aa. Equivalent to Rv0004, len: FT 187 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 187 aa overlap). Conserved hypothetical FT protein (see citation below), highly similar, but longer 21 FT aa in N-terminus, to AAF33696.1|AF222789 unknown protein FT from Mycobacterium avium subsp. paratuberculosis (166 aa); FT and highly similar to NP_301132.1|NC_002677 conserved FT hypothetical protein from Mycobacterium leprae (189 aa); FT S70990 hypothetical protein from Mycobacterium smegmatis FT (194 aa). Also similar to in C-terminus to C-terminal part FT of P35925|YREG_STRCO HYPOTHETICAL 19.8 KDA PROTEIN (IN FT RECF-GYRB INTERGENIC REGION) from Streptomyces coelicolor FT (190 aa), FASTA scores: opt: 404, E(): 3.9e-18, (40.7% FT identity in 189 aa overlap)." FT /db_xref="InterPro:IPR007922" FT /db_xref="UniProtKB/Swiss-Prot:Q7U313" FT /protein_id="CAD92866.1" FT /translation="MTGSVDRPDQNRGERLMKSPGLDLVRRTLDEARAAARARGQDAGR FT GRVASVASGRVAGRRRSWSGPGPDIRDPQPLGKAARELAKKRGWSVRVAEGMVLGQWSA FT VVGHQIAEHARPTALNDGVLSVIAESTAWATQLRIMQAQLLAKIAAAVGNDVVRSLKIT FT GPAAPSWRKGPRHIAGRGPRDTYG" FT CDS 5123..7267 FT /transl_table=11 FT /gene="gyrB" FT /locus_tag="Mb0005" FT /product="DNA GYRASE (SUBUNIT B) GYRB (DNA TOPOISOMERASE FT (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA FT TOPOISOMERASE)" FT /EC_number="5.99.1.3" FT /note="Mb0005, gyrB, len: 714 aa. Equivalent to Rv0005, FT len: 714 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 714 aa overlap). gyrB, DNA gyrase FT subunit B (EC 5.99.1.3) (see citations below), equivalent, FT except in N-terminus, to other Mycobacterial DNA GYRASES FT SUBUNIT B e.g. T10005 from Mycobacterium leprae (697 aa); FT Q9L7L3|GYRB_MYCPA from Mycobacterium avium subsp. FT paratuberculosis (677 aa) (has its N-terminus shorter); FT P48355|GYRB_MYCSM from Mycobacterium smegmatis (675 aa); FT etc. Also highly similar to others e.g. T10969 from FT Streptomyces coelicolor (686 aa); P50075|GYBS_STRSH from FT Streptomyces spheroides (684 aa); etc. Contains PS00177 DNA FT topoisomerase II signature. BELONGS TO THE TYPE II FT TOPOISOMERASE FAMILY." FT /db_xref="GOA:Q7U312" FT /db_xref="HSSP:1AJ6" FT /db_xref="InterPro:IPR006171" FT /db_xref="UniProtKB/TrEMBL:Q7U312" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92867.1" FT /translation="MGKNEARRSALAPDHGTVVCDPLRRLNRMHATPEESIRIVAAQKK FT KAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTV FT NVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVG FT VSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETT FT EYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTA FT PHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESV FT HTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV FT KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDSKVVVNKAVSSAQARIA FT ARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAI FT LPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDG FT QHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLK FT AGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGED FT VDARRSFITRNAKDVRFLDV" FT CDS 7302..9818 FT /transl_table=11 FT /gene="gyrA" FT /locus_tag="Mb0006" FT /product="DNA GYRASE (SUBUNIT A) GYRA (DNA TOPOISOMERASE FT (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA FT TOPOISOMERASE)" FT /EC_number="5.99.1.3" FT /note="Mb0006, gyrA, len: 838 aa. Equivalent to Rv0006, FT len: 838 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 838 aa overlap). gyrA, DNA gyrase FT subunit A (EC 5.99.1.3) (see citations below), equivalent, FT except in N-terminus, to other Mycobacterial DNA GYRASES FT SUBUNIT A e.g. Q57532|GYRA_MYCLE|T10006 from Mycobacterium FT leprae (1273 aa); P48354|GYRA_MYCSM from Mycobacterium FT smegmatis (842 aa); etc. Also highly similar to others e.g. FT P35885|GYRA_STRCO DNA GYRASE SUBUNIT A from Streptomyces FT coelicolor (864 aa); NP_346654.1|NC_003030 from Clostridium FT acetobutylicum (830 aa); NP_387888.1|NC_000964 from FT Bacillus subtilis (821 aa); etc. Contains PS00018 EF-hand FT calcium-binding domain." FT /db_xref="GOA:Q7U311" FT /db_xref="HSSP:1AB4" FT /db_xref="InterPro:IPR018247" FT /db_xref="UniProtKB/TrEMBL:Q7U311" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92868.1" FT /translation="MTDTTLPPDDSLDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVR FT DGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWS FT LRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEP FT TVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGR FT VKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHD FT NFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTS FT FGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALD FT ALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKI FT EAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVV FT VTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRV FT YRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKS FT KLTAFDSNRSGGIVAVNLRDNDELVGAVLCSADDDLLLVSANGQSIRFSATDEALRPMG FT RATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTV FT MYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTL FT LAIARNAEESGDDNAVDANGADQTGN" FT CDS 9914..10828 FT /transl_table=11 FT /gene="Mb0007" FT /locus_tag="Mb0007" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0007, -, len: 304 aa. Equivalent to Rv0007, len: FT 304 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 304 aa overlap). Possible conserved FT membrane protein, highly similar to Z70722|MLCB1770_7 from FT Mycobacterium leprae (303 aa), FASTA scores: opt: 812, E(): FT 1.6e-25, (54.2% identity in 319 aa overlap). C-terminal FT part highly similar to C-terminus of CAB92992.1|AL357152 FT putative integral membrane protein from Streptomyces FT coelicolor (185 aa); and N-terminal part highly similar to FT C-terminus of NP_302684.1|NC_002677 hypothetical protein FT from Mycobacterium leprae (123 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U310" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92869.1" FT /translation="MTAPNEPGALSKGDGPNADGLVDRGGAHRAATGPGRIPDAGDPPP FT WQRAATRQSQAGHRQPPPVSHPEGRPTNPPAAADARLNRFISGASAPVTGPAAAVRTPQ FT PDPDASLGCGDGSPAEAYASELPDLSGPTPRAPQRNPAPARPAEGGAGSRGDSAAGSSG FT GRSITAESRDARVQLSARRSRGPVRASMQIRRIDPWSTLKVSLLLSVALFFVWMITVAF FT LYLVLGGMGVWAKLNSNVGDLLNNASGSSAELVSSGTIFGGAFLIGLVNVVLMTALATI FT GAFVYNLITDLIGGIEVTLADRD" FT tRNA 10887..10960 FT /gene="ileT" FT /locus_tag="ileT" FT /note="ileT, len: 74 nt. Equivalent to ileT, len: 74 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 74 nt overlap). tRNA-Ile, anticodon gat." FT tRNA 11112..11184 FT /gene="alaT" FT /locus_tag="alaT" FT /note="alaT, len: 73 nt. Equivalent to alaT, len: 73 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 73 nt overlap). tRNA-Ala, anticodon tgc." FT CDS complement(11874..12311) FT /transl_table=11 FT /gene="Mb0008c" FT /locus_tag="Mb0008c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb0008c, -, len: 145 aa. Equivalent to Rv0008c, len: FT 145 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 144 aa overlap). Possible membrane FT protein." FT /db_xref="GOA:P59977" FT /db_xref="UniProtKB/Swiss-Prot:P59977" FT /protein_id="CAD92870.1" FT /translation="MSEQVETRLTPRERLTRGLAYSAVGPVDVTRGLLELGVGLGLQSA FT RSTAAGLRRRYREGRLAREVAAAQETLAQELTAAQDVVANLPQALQDARTQRRSKHHLW FT IFAGIAAAILAGGAVAFSIVRRSSRPEPSPRPPSVEVQPRP" FT CDS 12468..13016 FT /transl_table=11 FT /gene="ppiA" FT /locus_tag="Mb0009" FT /standard_name="cfp22" FT /product="PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS FT ISOMERASE A PPIA (PPIase A) (ROTAMASE A)" FT /EC_number="5.2.1.8" FT /note="Mb0009, ppiA, len: 182 aa. Equivalent to Rv0009, FT len: 182 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 182 aa overlap). Probable ppiA FT (alternate gene name: cfp22), iron-regulated FT peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8), FT equivalent to NP_301138.1|NC_002677 putative FT peptidyl-prolyl cis-trans isomerase from Mycobacterium FT leprae (182 aa), FASTA score: (90.1% identity in 182 aa FT overlap). Also highly similar to others e.g. T36725 from FT Streptomyces coelicolor (177 aa); T43805 from Halobacterium FT salinarum (180 aa); NP_219383.1|NC_000919 from Treponema FT pallidum (215 aa); etc. BELONGS TO THE CYCLOPHILIN-TYPE FT PPIASE FAMILY. Alternative start codon has been suggested." FT /db_xref="GOA:P65763" FT /db_xref="HSSP:1H0P" FT /db_xref="InterPro:IPR002130" FT /db_xref="UniProtKB/Swiss-Prot:P65763" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92871.1" FT /translation="MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVGL FT AQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFHPE FT LQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAISKTA FT TDGNDRPTDPVVIESITIS" FT CDS complement(13222..13557) FT /transl_table=11 FT /gene="Mb0010c" FT /locus_tag="Mb0010c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0010c, -, len: 111 aa. Equivalent to Rv0010c, len: FT 141 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 110 aa overlap). Probable conserved FT membrane protein, equivalent to NP_301139.1|NC_002677 FT putative membrane protein from Mycobacterium leprae (137 FT aa); and similar to Rv1417|P71686|YE17_MYCTU HYPOTHETICAL FT 16.4 KD PROTEIN from Mycobacterium tuberculosis (154 aa), FT FASTA scores: opt: 121, E(): 0.097, (29.6% identity in 81 FT aa overlap). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a single base deletion (g-*) leads to FT a shorter product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (111 aa versus 141 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U309" FT /protein_id="CAD92872.1" FT /translation="MQQTAWAPRTSGIAGCGAGGVVMAIASVTLVTDTPGRVLTGVAAL FT GLILFASATWRARPRLAITPDGLAIRGWFRTQLLRHSNIKIIRIDEFRRYGRLVRLLEI FT ETVSGGC" FT CDS complement(13713..13994) FT /transl_table=11 FT /gene="Mb0011c" FT /locus_tag="Mb0011c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0011c, -, len: 93 aa. Equivalent to Rv0011c, len: FT 93 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 93 aa overlap). Probable conserved FT transmembrane protein, equivalent to NP_301140.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (93 aa); and similar to AL079308|SCH69_24 hypothetical FT protein from Streptomyces coelicolor (84 aa), FASTA scores: FT opt: 135, E(): 0.0068, (32.6% identity in 92 aa overlap)." FT /db_xref="GOA:P67377" FT /db_xref="InterPro:IPR009619" FT /db_xref="UniProtKB/Swiss-Prot:P67377" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92873.1" FT /translation="MPKSKVRKKNDFTVSAVSRTPMKVKVGPSSVWFVSLFIGLMLIGL FT IWLMVFQLAAIGSQAPTALNWMAQLGPWNYAIAFAFMITGLLLTMRWH" FT CDS 14088..14876 FT /transl_table=11 FT /gene="Mb0012" FT /locus_tag="Mb0012" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0012, -, len: 262 aa. Equivalent to Rv0012, len: FT 262 aa, from Mycobacterium tuberculosis strain H37Rv (99.2% FT identity in 262 aa overlap). Probable conserved membrane FT protein, similar to AL079308|SCH69_23|T36722 hypothetical FT protein from Streptomyces coelicolor (237 aa), FASTA FT scores: opt: 506, E(): 1.9e-25, (39.8% identity in 236 aa FT overlap). Some similarity to BLU0|1958_35A2 DIVIB FT (fragment) (188 aa), FASTA scores: opt: 204, E(): 8.9e-07, FT (35.6% identity in 90 aa overlap); and G1129091|DDS cell FT division and sporulation protein from Bacillus subtilis FT (231 aa), FASTA scores: opt: 180, E(): 3.8e-05, (30.7% FT identity in 101 aa overlap). Also similar to FT Rv1823|MTCY1A11_20 from Mycobacterium tuberculosis FASTA FT score: (30.1% identity in 246 aa overlap); and MTCY1A11_18 FT FASTA score: (25.5% identity in 235 aa overlap). Contains FT probable N-terminal signal sequence." FT /db_xref="InterPro:IPR010273" FT /db_xref="UniProtKB/TrEMBL:Q7U308" FT /protein_id="CAD92874.1" FT /translation="MRLTHPTPCPENGETMIDRRRSAWRFSVPLVCLLAGLLLAATHGV FT SGGTEIRRSDAPRLVDLVRRAQASVNRLATEREALTTRIDSVHGRSVDTALAAMQRRSA FT ELAGVAAMNPVHGPGLVVTLQDAQRDANGRFPRDASPDDLVVHQQDIEAVLNALWNAGA FT EAIQMQDQRIIAMSIARCVGNTLLLNGRTYSPPYTIAAIGDAAAMQAALAAAPLVTLYK FT QYVVRFGLGYREEVHPDLQIVGYADPVRMHFAQPAGPLDY" FT CDS 14913..15611 FT /transl_table=11 FT /gene="trpG" FT /locus_tag="Mb0013" FT /product="POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG FT (GLUTAMINE AMIDOTRANSFERASE)" FT /EC_number="4.1.3.27" FT /note="Mb0013, trpG, len: 232 aa. Equivalent to Rv0013, FT len: 232 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 232 aa overlap). Possible trpG, FT anthranilate synthase component II (glutamine FT amidotransferase) (EC 4.1.3.27), equivalent to FT NP_301141.1|NC_002677 putative p-aminobenzoate synthase FT glutamine amidotransferase from Mycobacterium leprae (232 FT aa). Also highly similar to others e.g. P26922|TRPG_AZOBR FT Anthranilate synthase component II from Azospirillum FT brasilense (196 aa), FASTA scores: opt: 703, E(): 8.6e-40, FT (56.7% identity in 187 aa overlap); T36720 probable FT glutamine amidotransferase from Streptomyces coelicolor FT (212 aa); T44524 anthranilate synthase from Nitrosomonas FT europaea (199 aa); etc. Also similar to E235740 FT para-aminobenzoate synthase (232 aa), FASTA scores: opt: FT 1273, E(): 0, (79.7% identity in 232 aa overlap). Contains FT PS00606 Beta-ketoacyl synthases active site; and PS00442 FT Glutamine amidotransferases class-I active site. SIMILARITY FT TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAINS. Note FT that previously known as pabA." FT /db_xref="GOA:Q7U307" FT /db_xref="HSSP:1I1Q" FT /db_xref="InterPro:IPR000991" FT /db_xref="UniProtKB/TrEMBL:Q7U307" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92875.1" FT /translation="MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAG FT QFDGVLLSPGPGTPERAGASVSMVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPELL FT HGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQHTG FT LPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTAS FT AGEATGRTSA" FT CDS complement(15589..17469) FT /transl_table=11 FT /gene="pknB" FT /locus_tag="Mb0014c" FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE B FT PKNB (PROTEIN KINASE B) (STPK B)" FT /EC_number="2.7.1.-" FT /note="Mb0014c, pknB, len: 626 aa. Equivalent to Rv0014c, FT len: 626 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 626 aa overlap). pknB, transmembrane FT serine/threonine-protein kinase (EC 2.7.1.-) (see citations FT below), equivalent to MLCB1770_9|T10009 probable FT serine/threonine-specific protein kinase from Mycobacterium FT leprae (622 aa), FASTA scores: opt: 3600, E(): 0, (86.4% FT identity in 626 aa overlap). Also similar (highly similar FT in N-terminus) to others e.g. T36717 from Streptomyces FT coelicolor (673 aa); NP_389459.1|NC_000964 from Bacillus FT subtilis (648 aa); NP_465345.1|NC_003210 from Listeria FT monocytogenes (655 aa); E235741 protein kinase pknB (315 FT aa), FASTA scores: opt: 1839, E(): 0, (90.8 identity in 305 FT aa overlap); etc. Contains PS00107 Protein kinases FT ATP-binding region signature, and PS00108 Serine/Threonine FT protein kinases active-site signature. Contains Hank's FT kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN FT KINASES. Experimental studies show evidence of FT auto-phosphorylation on serine/threonine residues." FT /db_xref="GOA:P0A5S5" FT /db_xref="InterPro:IPR002290" FT /db_xref="UniProtKB/Swiss-Prot:P0A5S5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92876.1" FT /translation="MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRAD FT LARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIV FT HTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAI FT ADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPV FT SVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEP FT PEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLA FT VLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHV FT IGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSP FT STPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGF FT TKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEP FT RLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ" FT CDS complement(17466..18761) FT /transl_table=11 FT /gene="pknA" FT /locus_tag="Mb0015c" FT /product="TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE A FT PKNA (PROTEIN KINASE A) (STPK A)" FT /EC_number="2.7.1.-" FT /note="Mb0015c, pknA, len: 431 aa. Equivalent to Rv0015c, FT len: 431 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 431 aa overlap). pknA, transmembrane FT serine/threonine-protein kinase (EC 2.7.1.-), FT magnesium/manganese dependent (see citations below), FT equivalent to MLCB1770_10|NP_301143.1|NC_002677 putative FT serine/threonine protein kinase from Mycobacterium leprae FT (437 aa), FASTA scores: opt: 1883, E(): 0, (72.1% identity FT in 434 aa overlap). And also highly similar to other FT kinases from Mycobacterium leprae e.g. MLCB1770_10 from FT Mycobacterium leprae (437 aa). Also similar to PKNA_MYCLE FT protein kinase (253 aa), FASTA scores: opt: 1525, E(): 0, FT (95.0% identity in 242 aa overlap); etc. Also highly FT similar in part to others e.g. N-terminus of FT NP_243370.1|NC_002570 from Bacillus halodurans (664 aa); FT N-terminus of T36717 from Streptomyces coelicolor (673 aa); FT etc. Also similar to others from Mycobacterium FT tuberculosis: MTCY10H4_15, MTV021_9, MTCY28_5, MTCY4C12_28, FT MTCY50_16, MTCY8D9_8, MTCY49_28, MTCY4C12_30, MTCY28_9, FT etc. Contains PS00108 Serine/Threonine protein kinases FT active-site signature. Contains Hank's kinase subdomain. FT BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. It has FT been shown that sodium orthovanadate inhibits the activity FT of the enzyme in vitro." FT /db_xref="GOA:P65727" FT /db_xref="HSSP:1O6Y" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:P65727" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92877.1" FT /translation="MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLK FT SEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLN FT SVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIA FT KAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGA FT LTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPP FT RPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSRPATGGHRPPRRTFSSGQRAL FT LWAAGVLGALAIIIAVLLVIKAPGDNSPQQAPTPTVTTTGNPPASNTGGTDASPRLNWT FT ERGETRHSGLQSWVVPPTPHSRASLARYEIAQ" FT CDS complement(18758..20233) FT /transl_table=11 FT /gene="pbpA" FT /locus_tag="Mb0016c" FT /product="PROBABLE PENICILLIN-BINDING PROTEIN PBPA" FT /note="Mb0016c, pbpA, len: 491 aa. Equivalent to Rv0016c, FT len: 491 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 491 aa overlap). Probable pbpA, FT penicillin-binding protein, equivalent to FT NP_301144.1|NC_002677 putative penicillin-binding protein FT from Mycobacterium leprae (492 aa); and highly similar to FT MLCB1770_1 penicillin binding protein from Mycobacterium FT leprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4% FT identity in 472 aa overlap). Also similar to others e.g. FT T36716 from Streptomyces coelicolor (490 aa); FT AAF61246.1|AF241575|PbpA from Streptomyces griseus (485 FT aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum FT (482 aa); E235825|pbpA penicillin binding protein (325 aa), FT FASTA scores: opt: 1618, E(): 0, (78.3% identity in 323 aa FT overlap); etc. And also similar to MTCY270_5 and MTV003_8 FT from Mycobacterium tuberculosis." FT /db_xref="GOA:Q7U306" FT /db_xref="InterPro:IPR001460" FT /db_xref="UniProtKB/TrEMBL:Q7U306" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92878.1" FT /translation="MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVLL FT DEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALERAE FT DPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKGAVV FT ALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGS FT TFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKS FT CNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQK FT DVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVSPQVAAKL FT TELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPKVAVAV FT LVENGADRLSATGGALAAPIGRAVIEAALQGEP" FT CDS complement(20230..21639) FT /transl_table=11 FT /gene="rodA" FT /locus_tag="Mb0017c" FT /product="PROBABLE CELL DIVISION PROTEIN RODA" FT /note="Mb0017c, rodA, len: 469 aa. Equivalent to Rv0017c, FT len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 469 aa overlap). Probable rodA FT (alternate gene name: ftsW), cell division protein, FT integral membrane protein, equivalent to MLCB1770_12|T10012 FT probable cell division protein from Mycobacterium leprae FT (465 aa), FASTA scores: opt: 2475, E(): 0, (81.9% identity FT in 469 aa overlap). Also highly similar to others e.g. FT T36715|SCH69.16 from Streptomyces coelicolor (479 aa); FT NP_243432.1|NC_002570 from Bacillus halodurans (366 aa); FT NP_347145.1|NC_003030 from Clostridium acetobutylicum (400 FT aa); etc. Also similar to MTCY270_14 from Mycobacterium FT tuberculosis FASTA score: (32.2% identity in 369 aa FT overlap). BELONGS TO THE FTSW/RODA/SPOVE FAMILY." FT /db_xref="GOA:P63761" FT /db_xref="InterPro:IPR001182" FT /db_xref="UniProtKB/Swiss-Prot:P63761" FT /protein_id="CAD92879.1" FT /translation="MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQD FT QGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLVDN FT EIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPALLP FT AALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGMTLPR FT PRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTLFAAGT FT LVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQPDTVPAA FT STDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLSSTLAIQL FT FIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRTRPRNKSPI FT TAAGTEVIERV" FT CDS complement(21636..23180) FT /transl_table=11 FT /gene="ppp" FT /locus_tag="Mb0018c" FT /product="POSSIBLE SERINE/THREONINE PHOSPHATASE PPP" FT /EC_number="3.1.3.16" FT /note="Mb0018c, ppp, len: 514 aa. Equivalent to Rv0018c, FT len: 514 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 514 aa overlap). Possible ppp, FT serine/threonine phosphatase (EC 3.1.3.16), equivalent to FT MLCB1770_13|T10013 PUTATIVE PHOSPHOPROTEIN PHOSPHATASE from FT Mycobacterium leprae (509 aa), FASTA scores: opt: 2517, FT E(): 0. Also highly similar to others e.g. T36714 probable FT protein phosphatase from Streptomyces coelicolor (515 aa); FT CAA10712.1|AJ132604 pppL protein from Lactococcus lactis FT (258 aa); NP_248765.1|NC_002516 probable phosphoprotein FT phosphatase from Pseudomonas aeruginosa (242 aa); etc. Also FT similar to BSUB0009_46 YLOO PROTEIN from Bacillus subtilis FT (254 aa), FASTA score: (34.0% identity in 250 aa overlap)." FT /db_xref="GOA:Q7U305" FT /db_xref="InterPro:IPR015655" FT /db_xref="UniProtKB/TrEMBL:Q7U305" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92880.1" FT /translation="MALVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAA FT GEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAI FT LFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIM FT RALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELA FT LRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIV FT KRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMR FT GIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAG FT LPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPAAPSP FT TTSASAPTGTTPAIPTSASPAAPASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA" FT CDS complement(23269..23736) FT /transl_table=11 FT /gene="Mb0019c" FT /locus_tag="Mb0019c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0019c, -, len: 155 aa. Equivalent to Rv0019c, len: FT 155 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 155 aa overlap). Conserved hypothetical FT protein, equivalent to MLCB1770_14|NP_301147.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (155 aa), FASTA scores: opt: 902, E(): 0, (91.0% identity FT in 155 aa overlap). Also highly similar to FT T36713|AL079308|SCH69_14 from Streptomyces coelicolor (172 FT aa), FASTA scores: opt: 389, E(): 6e-21, (46.2% identity in FT 171 aa overlap); and similar in C-terminus to others e.g. FT NP_342559.1|NC_002754 Conserved hypothetical protein from FT Sulfolobus solfataricus (209 aa); etc. C-terminus also FT highly similar to C-terminal part of FT AAF07901.1|AF173844_2|AF173844 putative signal transduction FT protein GarA from Mycobacterium smegmatis (158 aa). Also FT similar to Rv1827|MTCY 1A11.16c from Mycobacterium FT tuberculosis ( 162 aa), FASTA score: (41.2% identity in 85 FT aa overlap); MTMOAIS_3; MAU66560_1 and MLCB1788_15." FT /db_xref="HSSP:1MZK" FT /db_xref="InterPro:IPR000253" FT /db_xref="UniProtKB/TrEMBL:Q7U304" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92881.1" FT /translation="MQGLVLQLTRAGFLMLLWVFIWSVLRILKTDIYAPTGAVMMRRGL FT ALRGTLLGARQRRHAARYLVVTEGALTGARITLSEQPVLIGRADDSTLVLTDDYASTRH FT ARLSMRGSEWYVEDLGSTNGTYLDRAKVTTAVRVPIGTPVRIGKTAIELRP" FT CDS complement(23860..25425) FT /transl_table=11 FT /gene="TB39.8" FT /locus_tag="Mb0020c" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB39.8" FT /note="Mb0020c, TB39.8, len: 521 aa. Equivalent to Rv0020c, FT len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, FT (97.9% identity in 527 aa overlap). TB39.8, conserved FT hypothetical protein, identified by proteomic study by the FT Statens Serum Institute, Denmark (spot TB39.8) (see FT citation below). Highly similar to NP_301148.1|NC_002677 FT conserved hypothetical protein from Mycobacterium leprae FT (488 aa); and Z70722|MLCB1770_15|T10015 hypothetical FT protein from Mycobacterium leprae (463 aa), FASTA scores: FT opt: 1213, E(): 2.2e-32, (72.3% identity in 506 aa FT overlap). Alternative start codon in position 24979 has FT been suggested. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a 18 bp deletion leads to a shorter FT product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (521 aa versus 527 aa)." FT /db_xref="HSSP:1MZK" FT /db_xref="InterPro:IPR000253" FT /db_xref="UniProtKB/TrEMBL:Q7U303" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92882.1" FT /translation="MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAA FT DRIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGWQTYGDV FT VVRFEQSSNLHTGQFRARGTVNPDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNSSYR FT GGQGQGRPDEYYDDRYARPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRPRHPG FT QGDYPEQIGYPDQGGYPEQRGYPDQRGHQDQGRGYPDQGQGGYPPPYEQRPPVSPGPAA FT GYGAPGYDQGYRQSGGCGPSPGGGQPGYGGYGEYGRGPARHEEGSYVPSGPPGPPEQRP FT AYPDQGGYDQGYQQGATTYGRQDYGGGADYTRYTESPQVPGYAPQGGGYAEPAGRDYDY FT GQSGAPDYGQPAPGGYSGYGQGGYGSAGTSVTLQLDDGSGRTYQLREGSNIIGRGQDAQ FT FRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEII FT VRMH" FT tRNA 25625..25707 FT /gene="leuT" FT /locus_tag="leuT" FT /note="leuT, len: 83 nt. Equivalent to leuT, len: 83 nt, FT from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 83 nt overlap). tRNA-Leu, anticodon cag." FT CDS complement(25894..26862) FT /transl_table=11 FT /gene="Mb0021c" FT /locus_tag="Mb0021c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0021c, -, len: 322 aa. Equivalent to Rv0021c, len: FT 322 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 322 aa overlap). Conserved hypothetical FT protein, similar to various proteins e.g. FT NP_464341.1|NC_003210 protein similar to oxidoreductases FT from Listeria monocytogenes (309 aa); NP_357973.1|NC_003098 FT Enoyl-acyl carrier protein(ACP) reductase from FT Streptococcus pneumoniae (324 aa); 2NPD_NEUCR|G726338 FT 2-nitropropane dioxygenase precursor from Neurospora crassa FT (378 aa), FASTA scores: opt: 383, E(): 1.1e-16, (32.2% FT identity in 348 aa overlap); etc. Also similar to FT AE001747_25 from Thermotoga maritima section 59 (314 aa), FT FASTA scores: opt: 442, E(): 1.5e-19, (30.5% identity in FT 325 aa overlap). Also similar to other proteins from FT Mycobacterium tuberculosis e.g. Rv3553 (355 aa), FASTA FT scores: E(): 6.8e-15, (35.3 identity in 235 aa overlap); FT and Rv1533 (375 aa), FASTA scores: E(): 4.7e-12, (34.4% FT identity in 262 aa overlap)." FT /db_xref="GOA:Q7U302" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR004136" FT /db_xref="UniProtKB/TrEMBL:Q7U302" FT /protein_id="CAD92883.1" FT /translation="MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGG FT GYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFAD FT AIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVT FT ARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLAATGD FT DMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAVPARDY FT SIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV" FT CDS complement(27004..27423) FT /transl_table=11 FT /gene="whiB5" FT /locus_tag="Mb0022c" FT /product="PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN FT WHIB-LIKE WHIB5" FT /note="Mb0022c, whiB5, len: 139 aa. Equivalent to Rv0022c, FT len: 139 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 139 aa overlap). Probable whiB5, FT WhiB-like regulatory protein (see citation below), similar FT to WhiB paralogue of Streptomyces coelicolor, wblE gene FT product (85 aa). Shows some similarity to FT O88103|AJ239086|SCO239086_1|WHID|SC6G4.45c|WBLB WHID FT PROTEIN from Streptomyces coelicolor (112 aa), FASTA FT scores: opt: 125, E(): 0.055, (37.1% identity in 97 aa FT overlap); and slight similarity to G466960|WHIB WHIB FT PROTEIN (102 aa), FASTA scores: opt: 112, E(): 0.14, (34.3 FT identity in 67 aa overlap)." FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q7U301" FT /protein_id="CAD92884.1" FT /translation="MAHPCATDPELWFGYPDDDGSDGAAKARAYERSATQARIQCLRRC FT PLLQQRRCAQHAVEHRVEYGVWAGIKLPGGQYRKREQLAAAHDVLRRIAGGEINSRQLP FT DNAALLARNEGLEVTPVPGVVVHLPIAQVGPQPAA" FT CDS 27576..28346 FT /transl_table=11 FT /gene="Mb0023" FT /locus_tag="Mb0023" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0023, -, len: 256 aa. Equivalent to Rv0023, len: FT 256 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 256 aa overlap). Possible FT transcriptional regulator, equivalent to FT CAB96432.1|AJ251434 hypothetical protein from Mycobacterium FT avium subsp. paratuberculosis (146 aa). N-terminus showing FT similarity with other transcriptional regulators e.g. FT AE0002|ECAE000240_9 from Escherichia coli strain K12 (178 FT aa), FASTA scores: opt: 149, E(): 0.0048, (33.3% identity FT in 84 aa overlap); etc. Contains probable helix-turn helix FT motif from aa 19 to 40 (Score 1615, +4.69 SD)." FT /db_xref="GOA:P67705" FT /db_xref="InterPro:IPR001387" FT /db_xref="UniProtKB/Swiss-Prot:P67705" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92885.1" FT /translation="MSRESAGAAIRALRESRDWSLADLAAATGVSTMGLSYLERGARKP FT HKSTVQKVENGLGLPPGTYSRLLVAADPDAELARLIAAQPSNPTAVRRAGAVVVDRHSD FT TDVLEGYAEAQLDAIKSVIDRLPATTSNEYETYILSVIAQCVKAEMLAASSWRVAVNAG FT ADSTGRLMEHLRALEATRGALLERMPTSLSARFDRACAQSSLPEAVVAALIGVGADEMW FT DIRNRGVIPAGALPRVRAFVDAIEASHDADEGQQ" FT CDS 28343..29176 FT /transl_table=11 FT /gene="Mb0024" FT /locus_tag="Mb0024" FT /product="PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN FT [FIRST PART]" FT /note="Mb0024, -, len: 277 aa. Equivalent to 5' end of FT Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 192 aa overlap). Putative FT secreted protein, p60 homologue, similar in part to others FT and relatives proteins e.g. P60_LISIV|Q01837 protein p60 FT precursor (invasion-associated protein) from Listeria FT ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, FT (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 FT putative NPL/P60 family secreted protein from Streptomyces FT coelicolor (347 aa) ; etc. Similar to Mycobacterium FT tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And FT several homologues in Streptomyces coelicolor e.g. FT AL049497|SC6G10_8|T35517 probable secreted protein (338 FT aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity FT in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / FT LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base deletion (c-*) splits Rv0024 into 2 parts, FT Mb0024 and Mb0025." FT /db_xref="UniProtKB/TrEMBL:Q7U300" FT /protein_id="CAD92886.1" FT /translation="MNYSEVELLSRAHQLFAGDSRRPGLDAGTTPYGDLLSRAADLNVG FT AGQRRYQLAVDHSRAALLSAARTDAAAGAVITGAQRDRAWARRSTGTVLDEARSDTTVT FT AVMPIAQREAIRRRVARLRAQRAHVLTARRRARRHLAALRALRYRVAHGPGVALAKLRL FT PSPSGRAGIAVHAALSRLGRPYVWGATGPTSSTVPVWSSGPTPRRVFTWIAPPINRSTR FT GSRCRAHRSGRAIWSSRTPGTCSWRSATIWSSRRPMRARRFGSARWATTCRFGDR" FT CDS 28918..29187 FT /pseudo FT /transl_table=11 FT /gene="Mb0025" FT /locus_tag="Mb0025" FT /product="PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN FT [SECOND PART]" FT /note="Mb0025, -, len: 89 aa. Equivalent to 3' end of FT Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 89 aa overlap). Putative FT secreted protein, p60 homologue, similar in part to others FT and relatives proteins e.g. P60_LISIV|Q01837 protein p60 FT precursor (invasion-associated protein) from Listeria FT ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, FT (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 FT putative NPL/P60 family secreted protein from Streptomyces FT coelicolor (347 aa) ; etc. Similar to Mycobacterium FT tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And FT several homologues in Streptomyces coelicolor e.g. FT AL049497|SC6G10_8|T35517 probable secreted protein (338 FT aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity FT in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / FT LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a FT single gene. In Mycobacterium bovis, a frameshift due to a FT single base deletion (c-*) splits Rv0024 into 2 parts, FT Mb0024 and Mb0025." FT CDS 29225..29587 FT /transl_table=11 FT /gene="Mb0026" FT /locus_tag="Mb0026" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0026, -, len: 120 aa. Equivalent to Rv0025, len: FT 120 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.2% identity in 120 aa overlap). Conserved hypothetical FT protein, showing some similarity to other proteins from FT Mycobacterium tuberculosis e.g. Rv0739 (268 aa), FASTA FT score: (37.6% identity in 101 aa overlap), and Rv0026 FASTA FT score: (35.4% identity in 113 aa overlap); etc." FT /db_xref="InterPro:IPR019710" FT /db_xref="UniProtKB/TrEMBL:Q7U2Z9" FT /protein_id="CAD92888.1" FT /translation="MSEQAGSSVAVIQERQALLARQHDAVAEADRELADVLASAHAAMR FT ESVRRLDAIAAELDRAVPDQDQLAVDTLMGAREFQTFLVAKQREIVAVVAAAHELDRAK FT SAVLKRLRAQYTEPAR" FT CDS 29702..31135 FT /transl_table=11 FT /gene="Mb0027" FT /locus_tag="Mb0027" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0027, -, len: 477 aa. Equivalent to 5' end of FT Rv0026, len: 448 aa, from Mycobacterium tuberculosis strain FT H37Rv, (94.4% identity in 449 aa overlap). Conserved FT hypothetical protein, showing some similarity to other FT proteins from Mycobacterium tuberculosis: Rv0025 FASTA FT score: (35.4% identity in 113 aa overlap) and Rv0739 (268 FT aa), FASTA score: (32.4% identity in 142 aa overlap). FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 4 FT bp insertion (*-atcg) leads to a longer protein with a FT different COOH part compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 FT aa)." FT /db_xref="InterPro:IPR019710" FT /db_xref="UniProtKB/TrEMBL:Q7U2Z8" FT /protein_id="CAD92889.1" FT /translation="MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVTS FT TTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHPNSATAQLDLQV FT VSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIREVV FT ATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPELPTRA FT EPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGATPALVP FT GVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDREGADED FT AGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQGIAIPLPG FT TAVANPVDPARISAGDVGVFTDRHALALGPSKALLDGQIQHISAVRGRNFLGWIHPAAT FT ATAPARTEAPTPTRPAAAR" FT CDS 31173..31490 FT /transl_table=11 FT /gene="Mb0028" FT /locus_tag="Mb0028" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0028, -, len: 105 aa. Equivalent to Rv0027, len: FT 105 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 105 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/Swiss-Prot:P64668" FT /protein_id="CAD92890.1" FT /translation="MTDRIHVQPAHLRQAAAHHQQTADYLRTVPSSHDAIRESLDSLGP FT IFSELRDTGRELLELRKQCYQQQADNHADIAQNLRTSAAMWEQHERAASRSLGNIIDGS FT R" FT CDS 31498..31803 FT /transl_table=11 FT /gene="Mb0029" FT /locus_tag="Mb0029" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0029, -, len: 101 aa. Equivalent to Rv0028, len: FT 101 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 101 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/Swiss-Prot:P64670" FT /protein_id="CAD92891.1" FT /translation="MTDANPAFDTVHPSGHILVRSCRGGYMHSVSLSEAAMETDAETLA FT EAILLTADVSCLKALLEVRNEIVAAGHTPSAQVPTTDDLNVAIEKLLAHQLRRRNR" FT CDS 32041..33138 FT /transl_table=11 FT /gene="Mb0030" FT /locus_tag="Mb0030" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0030, -, len: 365 aa. Equivalent to Rv0029, len: FT 365 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 365 aa overlap). Conserved hypothetical FT protein, showing some similarity to other proteins from FT Mycobacterium tuberculosis e.g. C-terminal region of FT Rv2082|MTCY49_21|E247006 hypothetical 73.6 kDa protein (721 FT aa), FASTA scores: opt: 453, E(): 1.2e-22, (38.5% identity FT in 265 aa overlap); Rv3899c|MTY15F10_12 HYPOTHETICAL 40.8 FT KD PROTEIN (410 aa), FASTA score: (33.7% identity in 252 aa FT overlap); etc." FT /db_xref="UniProtKB/TrEMBL:Q7U2Z7" FT /protein_id="CAD92892.1" FT /translation="MAIFGRWSARQRLRRATRESLTIPTFSSSLDCTTRVIGGLWPAEL FT SSNTAETATLAEHLKADLHRIVGSANDELMVIWRAGMADSTRRAEEDRVIDRARASAMR FT RVESAMRELRQITGRVPVEIPRMRGAGGSDLDTTRLMPAVTVVQPADQACTDWPVAAAE FT DDEARLQRLLAFVARQEPRLNWAVGVNADGTTVLVTDVAHGWIPPGIALPEGVRLLAPA FT RRAGRAPELVGITTCCKTYTPGDSLRRAVDSTAPTSSVQPRALPAIAGLSVELGIATQR FT HDGLPKIVHAMATAAGNGAAAEEVDLLRVHVDTALHHVLAQYPRVDPALLLNCMLLAAT FT ERSVTGDPIAANYHFAWFRELDSRR" FT CDS 33208..33537 FT /transl_table=11 FT /gene="Mb0031" FT /locus_tag="Mb0031" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0031, -, len: 109 aa. Equivalent to Rv0030, len: FT 109 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 109 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/Swiss-Prot:P64672" FT /protein_id="CAD92893.1" FT /translation="MVSGSDSRSEPSQLSDRDLVESVLRDLSEAADKWEALVTQAETVT FT YSVDLGDVRAVANSDGRLLELTLHPGVMTGYAHGELADRVNLAITALRDEVEAENRARY FT GGRLQ" FT CDS 33566..33778 FT /transl_table=11 FT /gene="Mb0032" FT /locus_tag="Mb0032" FT /product="PUTATIVE REMNANT OF A TRANSPOSASE" FT /note="Mb0032, -, len: 70 aa. Equivalent to Rv0031, len: 70 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 70 aa overlap). Possible remnant of a FT transposase, showing partial similarity to mycobacterial FT transposases in a short overlap, e.g. Rv2791c|MTV002_57 FT (459 aa), FASTA score: (72.2% identity in 36 aa overlap); FT Rv2885c, Rv2978c, Rv3827c, etc." FT /db_xref="UniProtKB/TrEMBL:Q7U2Z6" FT /protein_id="CAD92894.1" FT /translation="MLARHFGAGRKAHSRAVATLKADIQAWHPAGIQTPKPRCESDVFA FT RIGHTSHPSTRKSRVGPGASEAPLA" FT CDS 34279..36594 FT /transl_table=11 FT /gene="bioF2" FT /locus_tag="Mb0033" FT /product="POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 FT (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) FT (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP FT SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE)" FT /EC_number="2.3.1.47" FT /note="Mb0033, bioF2, len: 771 aa. Equivalent to Rv0032, FT len: 771 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 771 aa overlap). Probable bioF2, FT 8-amino-7-oxononanoate synthase (EC 2.3.1.47), with its FT C-terminal similar to others e.g. BIOF_BACSU|P53556 FT 8-amino-7-oxononanoate synthase from Bacillus subtilis (389 FT aa), FASTA scores: opt: 775, E(): 0, (37.9% identity in 346 FT aa overlap); P22806|BIOF_BACSH from Bacillus sphaericus FT (389 aa); etc. Also similar to BIOF1|Rv1569|MTCY336_35 from FT Mycobacterium tuberculosis (386 aa), AF041819_4 from FT Mycobacterium bovis, and BIOF_MYCLE|P45487 from FT Mycobacterium leprae (385 aa). Contains PS00599 FT Aminotransferases class-II pyridoxal-phosphate attachment FT site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT FT AMINOTRANSFERASES." FT /db_xref="GOA:Q7U2Z5" FT /db_xref="HSSP:1BS0" FT /db_xref="InterPro:IPR004839" FT /db_xref="UniProtKB/TrEMBL:Q7U2Z5" FT /protein_id="CAD92895.1" FT /translation="MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVC FT FDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPVLA FT GQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVEEAL FT GCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQREDLNP FT EFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYRKANLY FT RAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARM FT MMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFY FT PRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNG FT TLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDALNHRSLFDAA FT RLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLATIAELADRHGC FT RVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIR FT HNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQAEYHG FT TAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTSYLADHRQSDLDRA FT LHVFAGLAEDLTPQGAAL" FT CDS 36591..36854 FT /transl_table=11 FT /gene="acpA" FT /locus_tag="Mb0034" FT /standard_name="acpP" FT /product="PROBABLE ACYL CARRIER PROTEIN ACPA (ACP)" FT /note="Mb0034, acpA, len: 87 aa. Equivalent to Rv0033, len: FT 87 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 87 aa overlap). Probable acpA FT (alternate gene name: acpP), acyl carrier protein, similar FT to others e.g. ACP_BACSU|P80643 acyl carrier protein (acp) FT from Bacillus subtilis (77 aa), FASTA scores: opt: 149, FT E(): 0.00026, (41.4% identity in 70 aa overlap); FT NP_224500.1|NC_000922 Acyl Carrier Protein from FT Chlamydophila pneumoniae (79 aa); NP_228471.1|NC_000853 FT acyl carrier protein from Thermotoga maritima (81 aa); etc. FT Also similar to proteins of Mycobacterium tuberculosis FT Rv1344 and Rv2244 (31.5% identity in 73 aa overlap)." FT /db_xref="GOA:Q7U2Z4" FT /db_xref="InterPro:IPR009081" FT /db_xref="UniProtKB/TrEMBL:Q7U2Z4" FT /protein_id="CAD92896.1" FT /translation="MKEAINATIQRILRTDRGITANQVLVDDLGFDSLKLFQLITELED FT EFDIAISFRDAQNIKTVGDVYTSVAVWFPETAKPAPLGKGTA" FT CDS 36851..37246 FT /transl_table=11 FT /gene="Mb0035" FT /locus_tag="Mb0035" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0035, -, len: 131 aa. Equivalent to Rv0034, len: FT 131 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 131 aa overlap). Conserved hypothetical FT protein, showing weak similarity to AE001980|AE001980_7 FT hypothetical protein from Deinococcus radiodurans (120 aa), FT FASTA scores: opt: 141, E(): 0.0028, (29.3% identity in 123 FT aa overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64674" FT /protein_id="CAD92897.1" FT /translation="MTDDADLDLVRRTFAAFARGDLAELTQCFAPDVEQFVPGKHALAG FT VFRGVDNVVACLGDTAAAADGTMTVTLEDVLSNTDGQVIAVYRLRASRAGKVLDQREAI FT LVTVAGGRITRLSEFYADPAATESFWA" FT CDS 37243..38931 FT /transl_table=11 FT /gene="fadD34" FT /locus_tag="Mb0036" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD34 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb0036, fadD34, len: 562 aa. Equivalent to Rv0035, FT len: 562 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 562 aa overlap). Probable fadD34, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT e.g. MBU75685_1 acyl-CoA synthase from Mycobacterium bovis FT (582 aa), FASTA scores: opt: 408, E(): 8.2e-20; etc. Also FT similar to G1171128 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa), FT FASTA scores: opt: 445, E(): 1.3e-21, (28.1% identity in FT 573 aa overlap). Also similar to other proteins from FT Mycobacterium tuberculosis e.g. MTCY02B10.09, FASTA score: FT (32.3% identity in 468 aa overlap), MTCY349_40, MTCY4D9_17, FT MTCY338_18, MTV045_3, MTCY409_4, MTCI237_30, MTCY24G1_8, FT MASC_MYCLE MASC PROTEIN, U00010_6, MTV005_21, MTCY19G5_7, FT MTCY9F9_39, etc." FT /db_xref="GOA:Q7U2Z3" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U2Z3" FT /protein_id="CAD92898.1" FT /translation="MTAALLSPAIAWQQISACTDRTLTITCEDSEVISYQDLIARAAAC FT IPPLRRLDLKRGEPVLITAHTNLEFLSCFLGLMLHGAVPVPIPPREALKTTERFMTRLG FT PLLRHHRVLICTPAEHDEIRAAASTDCQISRFTALAEAGDEQFGRATAQQLADTATADW FT PLCTLDDDAYVQYTSGSTAAPRGVVITYRNLLSNMRAMAVGSQFQHGDVMGSWLPLHHD FT MGLVGSLFAALFNSVSAVFTTPHRFLYDPLGFLRLLTSSGATHTFMPNFALEWLINAYH FT RRGADIEGIDLHKMRRLIIASEPVHAEGMRRFAATFAGVGLAPTALGSGYGLAEATVAV FT SMSAPNTGFRTETHAAAEVVTGGRVLPGYEVRIDAAPGARAGTIKLRGDSVAAKAYVGG FT KKLDALDEEGFCDTHDLGFLVDDEIVILGRQDEVFIVHGENRFPYDIEFIIRGESEQHR FT TKVACFGVNERVVVVLESPLDSIIDKAEADRLRCQVVAATGLQLDELITVRRGAIPTTT FT SGKLKRRAVAQAYRDGTLPRLATHAWTADPDSAPKTTRSSLEGAH" FT CDS complement(39040..39813) FT /transl_table=11 FT /gene="Mb0037c" FT /locus_tag="Mb0037c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0037c, -, len: 257 aa. Equivalent to Rv0036c, len: FT 257 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 257 aa overlap). Conserved hypothetical FT protein, highly similar to CAB95889.1|AL359988 conserved FT hypothetical protein from Streptomyces (276 aa). Also some FT similarity to Rv3099c|MTCY164_10 (283 aa), FASTA scores: FT E(): 3.3e-05, (25.9 % identity in 205 aa overlap)." FT /db_xref="InterPro:IPR013917" FT /db_xref="UniProtKB/Swiss-Prot:P64676" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92899.1" FT /translation="MADPGPFVADLRAESDDLDALVAHLPADRWADPTPAPGWTIAHQI FT GHLLWTDRVALTAVTDEAGFAELMTAAAANPAGFVDDAATELAAVSPAELLTDWRVTRG FT RLHEELLAVPDGRKLAWFGPPMSAASMATARLMETWAHGLDVADALGVIRPATQRLRSI FT AHLGVRTRDYAFIVNNLTPPAEPFLVELRGPSGDTWSWGPSDAAQRVTGSAEDFCFLVT FT QRRALSTLDVNAVGEDAQRWLTIAQAFAGPPGRGR" FT CDS complement(39861..41186) FT /transl_table=11 FT /gene="Mb0038c" FT /locus_tag="Mb0038c" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0038c, -, len: 441 aa. Equivalent to Rv0037c, len: FT 441 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 441 aa overlap). Probable conserved FT integral membrane protein, member of major facilitator FT superfamily (MFS) possibly involved in transport of FT macrolide, showing some similarity to Rv1258c|MTCY50_24 FT (419 aa), FASTA score: (25.2% identity in 408 aa overlap); FT and to AL049826|SCH24_20 from Streptomyces coelicolor (425 FT aa), FASTA scores: opt: 725, E(): 0, (36.1% identity in 418 FT aa overlap). Also similarity with several MACROLIDE-EFFLUX FT PROTEINS e.g. from S. pyogenes (405 aa), FASTA scores: E(): FT 1.3e-06, (22.8% identity in 416 aa overlap)." FT /db_xref="GOA:P0A5C2" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/Swiss-Prot:P0A5C2" FT /protein_id="CAD92900.1" FT /translation="MPRVEVGLVIHSRMHARAPVDVWRSVRSLPDFWRLLQVRVASQFG FT DGLFQAGLAGALLFNPDRAADPMAIAGAFAVLFLPYSLLGPFAGALMDRWDRRWVLVGA FT NTGRLALIAGVGTILAVGAGDVPLLVGALVANGLARFVASGLSAALPHVVPREQVVTMN FT SVAIASGAVSAFLGANFMLLPRWLLGSGDEGASAIVFLVAIPVSIALLWSLRFGPRVLG FT PDDTERAIHGSAVYAVVTGWLHGARTVVQLPTVAAGLSGLAAHRMVVGINSLLILLLVR FT HVTARAVGGLGTALLFFAATGLGAFLANVLTPTAIRRWGRYATANGALAAAATIQVAAA FT GLLVPVMVVCGFLLGVAGQVVKLCADSAMQMDVDDALRGHVFAVQDALFWVSYILSITV FT AAALIPEHGHAPVFVLFGSAIYLAGLVVHTIVGRRGQPVIGR" FT CDS 41288..41896 FT /transl_table=11 FT /gene="Mb0039" FT /locus_tag="Mb0039" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0039, -, len: 202 aa. Equivalent to Rv0038, len: FT 202 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 202 aa overlap). Conserved hypothetical FT protein, equivalent to MLCB1770_16|Q50191|Y038_MYCLE FT hypothetical 22.0 kDa from Mycobacterium leprae (202 aa), FT FASTA scores: opt: 1194, E(): 0, (88.6% identity in 202 aa FT overlap). Also highly similar or similar to other FT hypothetical proteins e.g. CAB72194.1|AL138851|SCE59.07c FT from Streptomyces coelicolor (193 aa); AAC06288.1|AF050466 FT from Mycobacterium bovis (82 aa) (similarity in FT N-terminus); NP_224347.1|NC_000922|YqgE from Chlamydophila FT pneumoniae (188 aa); YQGE_ECOLI HYPOTHETICAL 20.7 KD FT PROTEIN (187 aa), FASTA score: (29.5% identity in 166 aa FT overlap); etc." FT /db_xref="InterPro:IPR003774" FT /db_xref="UniProtKB/Swiss-Prot:P67758" FT /protein_id="CAD92901.1" FT /translation="MVAPHEDPEDHVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIVE FT HNDGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKTMFIGGPVKRDAALCLAVLRVGADP FT EGVPGLRHVAGRLVMVDLDADPEVLAAAVEGVRIYAGYSGWTIGQLEGEIERDDWIVLS FT ALPSDVLVGPRADLWGQVLRRQPLPLSLLATHPIDLSRN" FT CDS complement(41988..42335) FT /transl_table=11 FT /gene="Mb0040c" FT /locus_tag="Mb0040c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0040c, -, len: 115 aa. Equivalent to Rv0039c, len: FT 115 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.1% identity in 115 aa overlap). Possible conserved FT transmembrane protein, highly similar to FT NP_301154.1|NC_002677|Z70722|MLCB1770_18 hypothetical FT protein from Mycobacterium leprae (113 aa), FASTA scores: FT opt: 492, E(): 7.8e-27, (64.9% identity in 114 aa FT overlap)." FT /db_xref="GOA:Q7U2Z2" FT /db_xref="UniProtKB/TrEMBL:Q7U2Z2" FT /protein_id="CAD92902.1" FT /translation="MFLAGVLCMCAAAASALFGSWSLFHTPTADPTALALRAMAPTQLA FT AAVMLAAGGVVAVAAPGHTALMVVIVCIAGAVGTLAAGSWQSAQYALRRETASPTANCV FT GSCAVCTQACH" FT CDS complement(42417..43349) FT /transl_table=11 FT /gene="mtc28" FT /locus_tag="Mb0041c" FT /product="SECRETED PROLINE RICH PROTEIN MTC28 (PROLINE RICH FT 28 KDA ANTIGEN)" FT /note="Mb0041c, mtc28, len: 310 aa. Equivalent to Rv0040c, FT len: 310 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 310 aa overlap). mtc28, secreted FT proline rich 28 kDa antigen protein (has hydrophobic FT stretch at N-terminus) (see citation below). Highly similar FT to O33075|PR28_MYCLE|MT10019 Proline rich 28 kDa antigen FT from Mycobacterium leprae (278 aa), FASTA scores: opt: FT 1007, E(): 0, (65.0% identity in 257 aa overlap); and FT Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 putative FT lipoprotein from Mycobacterium leprae (218 aa). C-terminal FT part very similar to lipoprotein Rv1016c from Mycobacterium FT tuberculosis." FT /db_xref="InterPro:IPR019674" FT /db_xref="UniProtKB/Swiss-Prot:P0A5Q7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92903.1" FT /translation="MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPV FT SAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISG FT TLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYT FT SNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYREND FT MTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPA FT PAPGSAPVGLPGQAPGYPPAGTLTPVPPR" FT CDS 43546..46455 FT /transl_table=11 FT /gene="leuS" FT /locus_tag="Mb0042" FT /product="PROBABLE LEUCYL-tRNA SYNTHETASE LEUS FT (LEUCINE--tRNA LIGASE) (LEURS)" FT /EC_number="6.1.1.4" FT /note="Mb0042, leuS, len: 969 aa. Equivalent to Rv0041, FT len: 969 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 969 aa overlap). Probable leucyl-tRNA FT synthetase (EC 6.1.1.4), equivalent to FT NP_301156.1|NC_002677|MLCB628_3 leucyl-tRNA synthase from FT Mycobacterium leprae (972 aa), FASTA score: (83.6% identity FT in 972 aa overlap); and highly similar to MLCB1770_20 from FT Mycobacterium leprae (824 aa), FASTA score: (82.8% identity FT in 824 aa overlap). Also highly similar to others e.g. FT CAB66249.1|AL136518 leucyl-tRNA synthetase from FT Streptomyces coelicolor (966 aa); NP_244147.1|NC_002570 FT leucyl-tRNA synthetase from Bacillus halodurans (806 aa); FT SYL_BACSU|P36430 leucyl-tRNA synthetase from Bacillus FT subtilis (804 aa), FASTA scores: opt: 714, E(): 3.1e-38, FT (43.7% identity in 938 aa overlap); etc. Contains PS00178 FT Aminoacyl-transfer RNA synthetases class-I signature. FT BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY." FT /db_xref="GOA:P67511" FT /db_xref="InterPro:IPR013155" FT /db_xref="UniProtKB/Swiss-Prot:P67511" FT /protein_id="CAD92904.1" FT /translation="MTESPTAGPGGVPRADDADSDVPRYRYTAELAARLERTWQENWAR FT LGTFNVPNPVGSLAPPDGAAVPDDKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARYFR FT MVGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGFGHDSRRSFS FT TTDVDFYRWTQWIFLQIYNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKLTAGE FT RADVIDEYRLVYRADSLVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRIT FT AYADRLLDDLDVLDWPEQVKTMQRNWIGRSTGAVALFSARAASDDGFEVDIEVFTTRPD FT TLFGATYLVLAPEHDLVDELVAASWPAGVNPLWTYGGGTPGEAIAAYRRAIAAKSDLER FT QESREKTGVFLGSYAINPANGEPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARAFG FT LPIVEVIAGGNISESAYTGDGILVNSDYLNGMSVPAAKRAIVDRLESAGRGRARIEFKL FT RDWLFARQRYWGEPFPIVYDSDGRPHALDEAALPVELPDVPDYSPVLFDPDDADSEPSP FT PLAKATEWVHVDLDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNSERFCAKENEAY FT WMGPRPAEHGPDDPGGVDLYVGGAEHAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQ FT GYIQAYAYTDARGSYVPAEQVIERGDRFVYPGPDGEVEVFQEFGKIGKSLKNSVSPDEI FT CDAYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVVDEHTGETRVADGVE FT LDIDTLRALHRTIVGVSEDFAALRNNTATAKLIEYTNHLTKKHRDAVPRAAVEPLVQML FT APLAPHIAEELWLRLGNTTSLAHGPFPKADAAYLVDETVEYPVQVNGKVRGRVVVAADT FT DEETLKAAVLTDEKVQAFLAGATPRKVIVVAGRLVNLVI" FT CDS complement(46565..47191) FT /transl_table=11 FT /gene="Mb0043c" FT /locus_tag="Mb0043c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY MARR-FAMILY)" FT /note="Mb0043c, -, len: 208 aa. Equivalent to Rv0042c, len: FT 208 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 208 aa overlap). Possible FT transcriptional regulatory protein, MarR-family, highly FT similar except in N-terminus to CAC32228.1|AL583926 FT putative MarR-family regulatory protein from Mycobacterium FT leprae (243 aa). Also similar in part to others e.g. FT AB76343.1|AL158061 putative MarR-family transcriptional FT regulator from Streptomyces coelicolor (163 aa); FT NP_384406.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR FT PROTEIN from Sinorhizobium meliloti (164 aa); FT NP_531782.1|NC_003304 transcriptional regulator, MarR FT family from Agrobacterium tumefaciens (151 aa); etc. Also FT some similarity to Mycobacterium tuberculosis proteins FT Rv2327, Rv0880, and Rv1404." FT /db_xref="GOA:Q7U2Z1" FT /db_xref="InterPro:IPR000835" FT /db_xref="UniProtKB/TrEMBL:Q7U2Z1" FT /protein_id="CAD92905.1" FT /translation="MSVVRSIGKKMQRISGPNALAVKGRPTQVYGHTHVRLDCRFMADS FT EFTAPEVTQLAEGLHRALSKLISMLRRGDPNGAAAGDLTLAQLSILVTLLDQGPIRMTD FT LAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRAVLVDITPQGRAVHGESLANRRAA FT LAALLSQLPRSDLETLRKALAPLERLASGEPASGPASNSPARKRA" FT CDS complement(47350..48084) FT /transl_table=11 FT /gene="Mb0044c" FT /locus_tag="Mb0044c" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT /note="Mb0044c, -, len: 244 aa. Equivalent to Rv0043c, len: FT 244 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 244 aa overlap). Probable FT transcriptional regulator, GntR family, similar to others FT e.g. NP_420584.1|NC_002696 transcriptional regulator GntR FT family from Caulobacter crescentus (221 aa); FT NP_294539.1|NC_001263 transcriptional regulator GntR family FT from Deinococcus radiodurans (267 aa); YIN1_STRAM|P32425 FT hypothetical transcriptional regulatory protein from FT Streptomyces ambofaciens (236 aa), FASTA scores: opt: 170, FT E(): 9.8e-05, (27.6% identity in 127 aa overlap); etc. FT Similar also to SC9B10_7 from Streptomyces coelicolor FASTA FT score: E():0.00038; and Rv0165c|MTCI28_5 from Mycobacterium FT tuberculosis (264 aa), FASTA score: (27.7% identity in 130 FT aa overlap)." FT /db_xref="GOA:P67738" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P67738" FT /protein_id="CAD92906.1" FT /translation="MPKKYGVKEKDQVVAHILNLLLTGKLRSGDRVDRNEIAHGLGVSR FT VPIQEALVQLEHDGIVSTRYHRGAFIERFDVATILEHHELDGLLNGIASARAAANPTPR FT ILGQLDAVMRSLRNSKESRAFAECVWEYRRTVNDEYAGPRLHATIRASQNLIPRVFWMT FT YQNSRDDVLPFYEEENAAIHRREPEAARAACIGRSELMAQTMLAELFRRRVLVPPEGAC FT PGPFGAPIPGFARSYQPSSPVP" FT CDS complement(48217..49011) FT /transl_table=11 FT /gene="Mb0045c" FT /locus_tag="Mb0045c" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0045c, -, len: 264 aa. Equivalent to Rv0044c, len: FT 264 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 264 aa overlap). Possible FT oxidoreductase (EC 1.-.-.-), highly similar to FT AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase FT from Streptomyces lavendulae (264 aa). Also similar to FT Mycobacterium tuberculosis proteins e.g. Rv1855c, Rv0953c, FT Rv0791c, Rv0132c, etc." FT /db_xref="GOA:Q7U2Z0" FT /db_xref="InterPro:IPR011251" FT /db_xref="UniProtKB/TrEMBL:Q7U2Z0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92907.1" FT /translation="MTSLVRPDLPVRIGVQLQPQHAPHYRAVRDAVRRCEDIGVDIAFT FT WDHFFPLYGDPDGPHFECWTVLGAWAEQTSHIEIGALVTCNSYRNPELLADMARTVDHI FT SGGRLILGIGSGWKQKDYDEYGYRFGTAGSRLDDLAAALPRIKARLGKLNPPPTRDIPV FT LIGGGGERKTLRLVAEYADIWHSFTAGDSYLAKSAVLSTHCSTVGRNPATIERSAAVDG FT GGLIASAEALAGLGVTLLTVGCDGPDYDLSAAAALCRWRDGR" FT CDS complement(49027..49923) FT /transl_table=11 FT /gene="Mb0046c" FT /locus_tag="Mb0046c" FT /product="POSSIBLE HYDROLASE" FT /EC_number="3.-.-.-" FT /note="Mb0046c, -, len: 298 aa. Equivalent to Rv0045c, len FT 298 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 298 aa overlap). Possible hydrolase (EC FT 3.-.-.-), showing similarity with others eg FT NP_107230.1|NC_002678 putative hydrolase from Mesorhizobium FT loti (278 aa); CAB56730.1|AL121600 putative hydrolase from FT Streptomyces coelicolor (302 aa); NP_438361.1|NC_000907 FT putative esterase/lipase from Haemophilus influenzae Rd FT (287 aa); etc. Also similar to Mycobacterium tuberculosis FT proteins Rv3473c, Rv1123c, Rv1938, Rv3617, Rv3670, etc." FT /db_xref="GOA:Q7U2Y9" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7U2Y9" FT /protein_id="CAD92908.1" FT /translation="MLSDDELTGLDEFALLAENAEQAGVNGPLPEVERVQAGAISALRW FT GGSAPRVIFLHGGGQNAHTWDTVIVGLGEPALAVDLPGHGHSAWREDGNYSPQLNSETL FT APVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLVDVTPSALQRHAELTAEQR FT GTVALMHGEREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNWVWRYDAIRT FT FGDFAGLWDDVDALSAPITLVRGGSSGFVTDQDTAELHRRATHFRGVHIVEKSGHSVQS FT DQPRALIEIVRGVLDTR" FT CDS complement(50005..51108) FT /transl_table=11 FT /gene="ino1" FT /locus_tag="Mb0047c" FT /standard_name="tbINO" FT /product="MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol FT 1-phosphate synthetase) (D-glucose 6-phosphate FT cycloaldolase) (Glucose 6-phosphate cyclase) FT (Glucocycloaldolase)" FT /EC_number="5.5.1.4" FT /note="Mb0047c, ino1, len: 367 aa. Equivalent to Rv0046c, FT len: 367 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 367 aa overlap). ino1 (alternate gene FT name: tbINO), myo-inositol-1-phosphate synthase (EC FT 5.5.1.4) (see citations below), equivalent to FT Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113 FT HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae FT (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity FT in 366 aa overlap). N-terminus similar to N-terminus of FT myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803 FT myo-inositol-1-phosphate synthase (510 aa), FASTA scores: FT opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap); FT CAC21218.1|AJ401007 myo-inositol 1P synthase from FT Thermotoga sp. SG1 (335 aa); etc. Also highly similar to FT other hypothetical proteins e.g. AL049826|SCH24_21c FT hypothetical protein from Streptomyces coelicolor (360 aa), FT FASTA scores: opt: 1790, E(): 0, (77.8% identity in 360 aa FT overlap); AE000881_1 conserved protein from M. FT thermoautotrophicus (368 aa); etc." FT /db_xref="GOA:P59967" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P59967" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92909.1" FT /translation="MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTST FT VPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQ FT RGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAID FT AGVAFVNALPVFIASDPVWAKKFTDAGVPIVGDDIKSQVGATITHRVLAKLFEDRGVQL FT DRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLD FT DRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPA FT SAYLMKSPPEQLPDDIARAQLEEFIIG" FT CDS complement(51169..51711) FT /transl_table=11 FT /gene="Mb0048c" FT /locus_tag="Mb0048c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0048c, -, len: 180 aa. Equivalent to Rv0047c, len: FT 180 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 180 aa overlap). Conserved hypothetical FT protein, equivalent to NP_302717.1|NC_002677 conserved FT hypothetical protein from Mycobacterium leprae (180 aa). FT Also showing strong similarity to other hypothetical FT proteins e.g. AL049826|SCH24_22|T36587 from Streptomyces FT coelicolor (225 aa), FASTA scores: opt: 583, E(): 9e-31, FT (51.4% identity in 177 aa overlap); etc. Some similarity to FT Rv1176c from Mycobacterium tuberculosis and to P94443|YFIO FT from Bacillus subtilis (182 aa), FASTA scores: E(): FT 0.00066, (24.9% identity in 177 aa overlap). Also some FT similarity to G1163121 MITHRAMYCIN RESISTANCE DETERMINANT, FT ATP-BINDING PROTEIN (219 aa), FASTA scores: opt: 143, E(): FT 0.0091, (29.4% identity in 180 aa overlap)." FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7U2Y8" FT /protein_id="CAD92910.1" FT /translation="MLELAILGLLIESPMHGYELRKRLTGLLGAFRAFSYGSLYPALRR FT MQADGLIAENAAPAGTPVRRARRVYQLTDKGRRRFGELVADTGPHNYTDDGFGVHLAFF FT NRTPAEARMRILEGRRRQVEERREGLREAVARASSSFDRYTRQLHQLGLESSEREVKWL FT NELIAAERAAPNPAEQT" FT CDS complement(51812..52681) FT /transl_table=11 FT /gene="Mb0049c" FT /locus_tag="Mb0049c" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb0049c, -, len: 289 aa. Equivalent to Rv0048c, len: FT 289 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 289 aa overlap). Possible membrane FT protein." FT /db_xref="InterPro:IPR012551" FT /db_xref="UniProtKB/TrEMBL:Q7U2Y7" FT /protein_id="CAD92911.1" FT /translation="MAKWLGAPLARGVSTATRAKDSDRQDACRILDDALRDGELSMEEH FT RERVSAATKAVTLGDLQRLVADLQVESAPAQMPALKSRAKRTELGLLAAAFVASVLLGV FT GIGWGVYGNTRSPLDFTSDPGAKPDGIAPVVLTPPRQLHSLGGLTGLLEQTRKRFGDTM FT GYRLVIYPEYASLDRVDPADDRRVLAYTYRGGWGDATSSAKSIADVSVVDLSKFDAKTA FT VSIMRGAPETLGLKQSDVKSMYLIVEPAKDPTTPAALSLSLYVSSDYGGGYLVFAGDGT FT IKHVSYPS" FT CDS 52815..53228 FT /transl_table=11 FT /gene="Mb0050" FT /locus_tag="Mb0050" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0050, -, len: 137 aa. Equivalent to Rv0049, len: FT 137 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 137 aa overlap). Conserved hypothetical FT protein, only equivalent to AL022118|MLCB1913_20 FT hypothetical protein from Mycobacterium leprae (138 aa), FT FASTA scores: opt: 768, E(): 0, (83.9% identity in 137 aa FT overlap)." FT /db_xref="UniProtKB/Swiss-Prot:P64678" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92912.1" FT /translation="MDYTLRRRSLLAEVYSGRTGVSEVCDANPYLLRAAKFHGKPSRVI FT CPICRKEQLTLVSWVFGEHLGAVSGSARTAEELILLATRFSEFAVHVVEVCRTCSWNHL FT VKSYVLGAARPARPPRGSGGTRTARNGARTASE" FT CDS 53647..55689 FT /transl_table=11 FT /gene="ponA1" FT /locus_tag="Mb0051" FT /product="PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN FT 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): FT PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN FT TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE FT (DD-TRANSPEPTIDASE)" FT /EC_number="2.4.2.-" FT /EC_number="3.4.-.-" FT /note="Mb0051, ponA1, len: 680 aa. Equivalent to Rv0050, FT len: 678 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 680 aa overlap). Probable ponA1, FT penicillin-binding protein (class A), bienzymatic protein FT with transglycosylase (EC 2.4.2.-) and transpeptidase (EC FT 3.4.-.-) activities, highly similar to many e.g. FT NP_302715.1|NC_002677 penicillin-binding protein from FT Mycobacterium leprae (708 aa); AAB53123.1|L39923 penicillin FT binding protein from Mycobacterium leprae (686 aa), FASTA FT scores: (82.3% identity in 679 aa overlap); FT Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523 FT penicillin-binding protein 1 from Mycobacterium smegmatis FT (715 aa) (see citation below); CAB88838.1|AL353832 probable FT penicillin-binding protein from Streptomyces coelicolor FT (756 aa); etc. Also similar to ponA2|Rv3682|MTV025.030 FT BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN FT 1A/1B from Mycobacterium tuberculosis (810 aa). BELONGS TO FT THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND FT TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, two FT insertions of 3 bp each (*-tcc, *-cgt) leads to a slightly FT longer product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (680 aa versus 678 aa)." FT /db_xref="GOA:Q7U2Y6" FT /db_xref="InterPro:IPR001264" FT /db_xref="UniProtKB/TrEMBL:Q7U2Y6" FT /protein_id="CAD92913.1" FT /translation="MVILLLMVTFTMAYLIVDVPKPGDIRTNQVSTILASDGSEIAKIV FT PPEGNRVDVNLSQVPMHVRQAVIAAEDRNFYSNPGFSFTGFARAVKNNLFGGDLQGGST FT ITQQYVKNALVGSAQHGWSGLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRGAYG FT ISAASKAYFDKPVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMVETKA FT LSPNDRAAQVFPETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQTLNTQGLVV FT TTTIDPQAQRAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVRAYYGGDNANGFDFAQAG FT LQTGSSFKVFALVAALEQGIGLGYQVDSSPLTVDGIKITNVEGEGCGTCNIAEALKMSL FT NTSYYRLMLKLNGGPQAVADAAHQAGIASSFPGVAHTLSEDGKGGPPNNGIVLGQYQTR FT VIDMASAYATLAASGIYHPPHFVQKVVSANGQVLFDASTADNTGDQRIPKAVADNVTAA FT MEPIAGYSRGHNLAGGRDSAAKTGTTQFGDTTANKDAWMVGYTPSLSTAVWVGTVKGDE FT PLVTASGAAIYGSGLPSDIWKATMDGALKGTSNETFPKPTEVGGYAGVPPPPPPPPSEV FT PPSETVIQPTVEIAPGITIPIGPPTTITLAPPPPAPPAATPTPPP" FT CDS 55686..57368 FT /transl_table=11 FT /gene="Mb0052" FT /locus_tag="Mb0052" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0052, -, len: 560 aa. Equivalent to Rv0051, FT len:560 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 560 aa overlap). Probable conserved FT transmembrane protein, equivalent to NP_302714.1|NC_002677 FT conserved membrane protein from Mycobacterium leprae (564 FT aa); and highly similar to C-terminus of FT AAF25828.1|AF187306_1|AF187306 putative transmembrane FT protein from Mycobacterium smegmatis (692 aa). Also highly FT similar to MSGDNAB_5|G886306|L222-ORF5 (418 aa), FASTA FT scores: opt: 2163, E(): 0, (78.4% identity in 412 aa FT overlap). Also similar to AL049826|SCH24_24|T36589 probable FT transmembrane protein from Streptomyces coelicolor (502 FT aa), FASTA scores: opt: 492, E(): 1.4e-23, (35.8% identity FT in 522 aa overlap)." FT /db_xref="GOA:Q7U2Y5" FT /db_xref="InterPro:IPR016570" FT /db_xref="UniProtKB/TrEMBL:Q7U2Y5" FT /protein_id="CAD92914.1" FT /translation="MTGALSQSSNISPLPLAADLRSADNRDCPSRTDVLGAALANVVGG FT PVGRHALIGRTRLMTPLRVMFAIALVFLALGWSTKAACLQSTGTGPGDQRVANWDNQRA FT YYQLCYSDTVPLYGAELLSQGKFPYKSSWIETDSNGTPQLRYDGQIAVRYMEYPVLTGI FT YQYLSMAIAKTYTALSKVAPLPVVAEVVMFFNVAAFGLALAWLTTVWATSGLAGRRIWD FT AALVAASPLVIFQIFTNFDALATGLATSGLLAWARRRPVLAGVLIGLGSAAKLYPLLFL FT YPLLLLGIRAGRLNALARTMAAAAATWLLVNLPVMLLFPRGWSEFFRLNTRRGDDMDSL FT YNVVKSFTGWRGFDPTLGFWEPPLVLNTVVTLLFVLCCAAIAYIALTAPHRPRVAQLTF FT LTVASFLLVNKVWSPQFSLWLVPLAVLALPHRRILLAWMTIDALVWVPRMYYLYGNPSR FT SLPEQWFTTTVLLRDIAVMVLCGLVVWQIYRPGRDLVRTGGPGALPACGGVDDPVGGVF FT ANAADAPPGRLPSWLRPRLGDEHARERTPDAGRDRTFSGQHRA" FT CDS 57400..57963 FT /transl_table=11 FT /gene="Mb0053" FT /locus_tag="Mb0053" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0053, -, len: 187 aa. Equivalent to Rv0052, len: FT 187 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 187 aa overlap). Conserved hypothetical FT protein, similar to others e.g. AL049587|SC5F2A_30S|T35272 FT hypothetical protein from Streptomyces coelicolor (211 aa), FT FASTA scores: opt: 531, E(): 3.4e-29, (49.5% identity in FT 182 aa overlap); NP_420588.1|NC_002696 ThiJ/PfpI family FT protein from Caulobacter crescentus (267 aa); etc. Some FT similarity to Escherichia coli G1100872|thiJ (198 aa), FT FASTA scores: opt: 178, E(): 6.1e-06, (29.9% identity in FT 137 aa overlap). Also similar to Rv1930c from Mycobacterium FT tuberculosis (174 aa). May be a membrane protein." FT /db_xref="InterPro:IPR002818" FT /db_xref="UniProtKB/TrEMBL:Q7U2Y4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92915.1" FT /translation="MPSFDVVFVGHRRGEVRSDNAMLGLLCDAAFDELTRPDVVIFPGG FT IGTRTLIHDQTVLDWVREAHRHTLLTTSVCTGGLVLAAAGLLNGLTATTHWRVQDLFNS FT LGARYVPQRVVEHLPERVITAAGVSSGIDMGLRLVELLVSREAAEASQLMIEYDPQPPV FT DAGSLAKASPATHRLALEFYQHRL" FT CDS 58182..58472 FT /transl_table=11 FT /gene="rpsF" FT /locus_tag="Mb0054" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S6 RPSF" FT /note="Mb0054, rpsF, len: 96 aa. Equivalent to Rv0053, len: FT 96 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 96 aa overlap). Probable 30S ribosomal FT protein S6, equivalent to RS6_MYCLE|P46389 30s ribosomal FT protein s6 from Mycobacterium leprae (96 aa), FASTA scores: FT opt: 570, E(): 1.1e-36, (91.7% identity in 96 aa FT overlap).Also highly similar to many e.g. Q9X8U2|RS6_STRCO FT 30S RIBOSOMAL PROTEIN S6 from Streptomyces coelicolor (96 FT aa); etc. Note that the putative product of this CDS FT corresponds to spot 6_26 identified in culture supernatant FT by proteomics at the Max-Planck-Institut fuer FT Infektionsbiologie (see citations below). Contains PS01048 FT Ribosomal protein S6 signature. BELONGS TO THE S6P FAMILY FT OF RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66592" FT /db_xref="HSSP:1CQM" FT /db_xref="InterPro:IPR014717" FT /db_xref="UniProtKB/Swiss-Prot:P66592" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92916.1" FT /translation="MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGKVEKVDIWGK FT RRLAYEIAKHAEGIYVVIDVKAAPATVSELDRQLSLNESVLRTKVMRTDKH" FT CDS 58576..59070 FT /transl_table=11 FT /gene="ssb" FT /locus_tag="Mb0055" FT /product="PROBABLE SINGLE-STRAND BINDING PROTEIN SSB FT (HELIX-DESTABILIZING PROTEIN)" FT /note="Mb0055, ssb, len: 164 aa. Equivalent to Rv0054, len: FT 164 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 164 aa overlap). Probable ssb, FT single-strand binding protein, equivalent to highly similar FT to others e.g. SSB_MYCLE|P46390 single-strand binding FT protein from Mycobacterium leprae (140 aa), FASTA scores: FT opt: 792, E(): 0, (92.6% identity in 135 aa overlap); and FT AAK30583.1|AF349434 single-stranded DNA-binding protein FT from Mycobacterium smegmatis (165 aa). Also highly similar FT to others e.g. T36594 probable single-strand binding FT protein from Streptomyces coelicolor (199 aa); etc. Also FT similar to Rv2478c|MTV008_34c CONSERVED HYPOTHETICAL FT PROTEIN from Mycobacterium tuberculosis (161 aa), FASTA FT score: E (): 1.1e-06. Note that the putative product of FT this CDS corresponds to spot 3_210 identified in culture FT supernatant by proteomics at the Max-Planck-Institut fuer FT Infektionsbiologie (see citations below). BELONGS TO THE FT SSB FAMILY." FT /db_xref="GOA:P0A611" FT /db_xref="InterPro:IPR011344" FT /db_xref="UniProtKB/Swiss-Prot:P0A611" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92917.1" FT /translation="MAGDTTITIVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQTG FT EWKDGEALFLRCNIWREAAENVAESLTRGARVIVSGRLKQRSFETREGEKRTVIEVEVD FT EIGPSLRYATAKVNKASRSGGFGSGSRPAPAQTSSASGDDPWGSAPASGSFGGGDDEPP FT F" FT CDS 59112..59366 FT /transl_table=11 FT /gene="rpsR1" FT /locus_tag="Mb0056" FT /product="PROBABLE 30S RIBOSOMAL PROTEIN S18-1 RPSR1" FT /note="Mb0056, rpsR1, len: 84 aa. Equivalent to Rv0055, FT len: 84 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 84 aa overlap). Probable rpsR1, 30S FT ribosomal protein S18-1, equivalent to FT NP_302711.1|NC_002677|O53125|RS18_MYCLE 30S RIBOSOMAL FT PROTEIN from Mycobacterium leprae (84 aa). Also highly FT similar to others e.g. Q9X8U4|R18A_STRCO 30S RIBOSOMAL FT PROTEIN S18-1 from Streptomyces coelicolor (78 aa); FT RS18_B|ACST|P10806 30s ribosomal protein s18 (bs21) (77 FT aa), FASTA scores: opt: 220, E(): 4e-10, (52.2% identity in FT 67 aa overlap); etc. Also similar to MTCY63A_5 from FT Mycobacterium tuberculosis. BELONGS TO THE S18P FAMILY OF FT RIBOSOMAL PROTEINS. Note that previously known as rpsR." FT /db_xref="GOA:P69231" FT /db_xref="InterPro:IPR018275" FT /db_xref="UniProtKB/Swiss-Prot:P69231" FT /protein_id="CAD92918.1" FT /translation="MAKSSKRRPAPEKPVKTRKCVFCAKKDQAIDYKDTALLRTYISER FT GKIRARRVTGNCVQHQRDIALAVKNAREVALLPFTSSVR" FT CDS 59399..59857 FT /transl_table=11 FT /gene="rplI" FT /locus_tag="Mb0057" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L9 RPLI" FT /note="Mb0057, rplI, len: 152 aa. Equivalent to Rv0056, FT len: 152 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 152 aa overlap). Probable rplI, 50S FT ribosomal protein L9, equivalent to RL9_MYCLE|P46385 50s FT ribosomal protein l9 from Mycobacterium leprae (152 aa), FT FASTA scores: opt: 847, E(): 0, (88.7% identity in 150 aa FT overlap). Also highly similar to others e.g. FT Q9X8U5|RL9_STRCO 50S RIBOSOMAL PROTEIN L9 from Streptomyces FT coelicolor (148 aa); etc. Contains PS00651 Ribosomal FT protein L9 signature. BELONGS TO THE L9P FAMILY OF FT RIBOSOMAL PROTEINS." FT /db_xref="GOA:P66316" FT /db_xref="HSSP:1CQU" FT /db_xref="InterPro:IPR020070" FT /db_xref="UniProtKB/Swiss-Prot:P66316" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92919.1" FT /translation="MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQK FT QADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVAAI FT KKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS" FT CDS 59886..60407 FT /transl_table=11 FT /gene="Mb0058" FT /locus_tag="Mb0058" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0058, -, len: 173 aa. Equivalent to Rv0057, len: FT 173 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 173 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/Swiss-Prot:P64680" FT /protein_id="CAD92920.1" FT /translation="MPVVTAVGRRRGFAMPWVSTARSGAVMLANYSAGVCGRVSSPGLN FT VRKMCLKANTPGAVTWLDTPKRFLSTQTASRCMAVNSSDVVTGRIDPQVLHTPLNTDVD FT GYAHAMHSSINSGPLEYLPATFSVFPALGDVGDLGGGVGAATYALDRLSNMRSGACVGG FT GESPWRSLMT" FT CDS 60386..63010 FT /transl_table=11 FT /gene="dnaB" FT /locus_tag="Mb0059" FT /product="PROBABLE REPLICATIVE DNA HELICASE DNAB" FT /EC_number="3.6.1.-" FT /note="Mb0059, dnaB, len: 874 aa. Equivalent to Rv0058, FT len: 874 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 874 aa overlap). Probable dnaB, FT replicative DNA helicase (EC 3.6.1.-). Contains an intein FT (position 61630..62838) similar to, and in the same FT position as, those in Sycnechocystis and Rhodothermus FT marinus (see citation below). Highly similar to others e.g. FT DNAB_SYNY3|Q55418 replicative dna helicase (872 aa), FASTA FT scores: opt: 533, E(): 0, (32.5% identity in 424 aa FT overlap). Also similar to intein recA|E1173867|AL008967 FT RECA INTEIN from Mycobacterium tuberculosis (442 aa), FASTA FT scores: E(): 3.8e-16, (27.0% identity in 426 aa overlap). FT C-terminal extein (position 62839..63015) similar to many FT dnaB proteins e.g. NP_302709.1|NC_002677|P46394|DNAB_MYCLE FT REPLICATIVE DNA HELICASE from Mycobacterium leprae (604 FT aa); DNAB_ECOLI|P03005 replicative dna helicase from FT Escherichia coli (471 aa), FASTA scores: opt: 148, E(): FT 1.5e-07, (37.9% identity in 58 aa overlap); etc. THIS FT PROTEIN UNDERGOES A PROTEIN SELF SPLICING THAT INVOLVES A FT POST-TRANSLATIONAL EXCISION OF THE INTERVENING REGION FT (INTEIN) FOLLOWED BY PEPTIDE LIGATION. BELONGS TO THE FT HELICASE FAMILY, DNAB SUBFAMILY. IN THE INTEIN SECTION; FT BELONGS TO THE HOMING ENDONUCLEASE FAMILY." FT /db_xref="GOA:P59966" FT /db_xref="InterPro:IPR006141" FT /db_xref="UniProtKB/Swiss-Prot:P59966" FT /protein_id="CAD92921.1" FT /translation="MAVVDDLAPGMDSSPPSEDYGRQPPQDLAAEQSVLGGMLLSKDAI FT ADVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRRIGGAPYLH FT TLISTVPTAANAGYYASIVAEKALLRRLVEAGTRVVQYGYAGAEGADVAEVVDRAQAEI FT YDVADRRLSEDFVALEDLLQPTMDEIDAIASSGGLARGVATGFTELDEVTNGLHPGQMV FT IVAARPGVGKSTLGLDFMRSCSIRHRMASVIFSLEMSKSEIVMRLLSAEAKIKLSDMRS FT GRMSDDDWTRLARRMSEISEAPLFIDDSPNLTMMEIRAKARRLRQKANLKLIVVDYLQL FT MTSGKKYESRQVEVSEFSRHLKLLAKELEVPVVAISQLNRGPEQRTDKKPMLADLRESG FT CLTASTRILRADTGAEVAFGELMRSGERPMVWSLDERLRMVARPMINVFPSGRKEVFRL FT RLASGREVEATGSHPFMKFEGWTPLAQLKVGDRIAAPRRVPEPIDTQRMPESELISLAR FT MIGDGSCLKNQPIRYEPVDEANLAAVTVSAAHSDGAAIRDDYLAARVPSLRPARQRLPR FT GRCTPIAAWLAGLGLFTKRSHEKCVPEAVFRAPNDQVALFLRHLWSAGGSVRWDPTNGQ FT GRVYYGSTSRRLIDDVAQLLLRVGIFSWITHAPKLGGHDSWRLHIHGAKDQVRFLRHVG FT VHGAEAVAAQEMLRQLKGPVRNPNLDSAPKKVWAQVRNRLSAKQMMDIQLHEPTMWKHS FT PSRSRPHRAEARIEDRAIHELARGDAYWDTVVEITSIGDQHVFDGTVSGTHNFVANGIS FT LHNSLEQDADVVILLHRPDAFDRDDPRGGEADFILAKHRNGPTKTVTVAHQLHLSRFAN FT MAR" FT CDS 63190..63882 FT /transl_table=11 FT /gene="Mb0060" FT /locus_tag="Mb0060" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0060, -, len: 230 aa. Equivalent to Rv0059, len: FT 230 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 230 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2Y3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92922.1" FT /translation="MITRYKPESGFVARSGGPDRKRPHDWIVWHFTHADNLPGIITAGR FT LLADSAVTPTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSPMLYVVCKG FT HSGYSGGAGPLVHLGVALGDIIDADLTWCASDGNAAASYTKFSRQVDTLGTFVDFDLLC FT QRQWHNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYNTETMTRVRTLLDPVGGVRKY FT VIKPGMYY" FT CDS 63899..64957 FT /transl_table=11 FT /gene="Mb0061" FT /locus_tag="Mb0061" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0061, -, len: 352 aa. Equivalent to Rv0060, len: FT 352 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 352 aa overlap). Conserved hypothetical FT protein, showing weak similarity to NP_104623.1|NC_002678 FT hypothetical protein from Mesorhizobium loti (155 aa); and FT AP000062|AP000062_92 hypothetical protein from Aeropyrum FT pernix (194 aa), FASTA scores: opt: 186, E(): 4.2e-05, FT (30.9% identity in 165 aa overlap)." FT /db_xref="InterPro:IPR002589" FT /db_xref="UniProtKB/TrEMBL:Q7U2Y2" FT /protein_id="CAD92923.1" FT /translation="MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFTA FT YEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRVIR FT ELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVEGLR FT MTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFTPGRY FT GPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAAADRVS FT AAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGRIYSDDR FT IGVALDRILMTA" FT CDS 64981..65406 FT /transl_table=11 FT /gene="Mb0062" FT /locus_tag="Mb0062" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0062, -, len: 141 aa. Equivalent to Rv0061, len: FT 141 aa (questionable ORF), from Mycobacterium tuberculosis FT strain H37Rv, (100.0% identity in 141 aa overlap). FT Hypothetical unknown protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2Y1" FT /protein_id="CAD92924.1" FT /translation="MCADAQPSGSVGLLGRNCPTATTRWRRAGEGLTAADTIEVKLWAG FT KPRLHPLVPKRAVGVLLAVAHGQVAKTPSATRAIAFRHVRLMRVRWICAGNRGRKHKRR FT CTTQYRSTQASKLQLHFKLRQTLNRLGGLQAMVSACG" FT CDS 65542..66684 FT /transl_table=11 FT /gene="celA1" FT /locus_tag="Mb0063" FT /product="POSSIBLE CELLULASE CELA1 (ENDOGLUCANASE) FT (ENDO-1,4-BETA-GLUCANASE) (FI-CMCASE) (CARBOXYMETHYL FT CELLULASE)" FT /EC_number="3.2.1.4" FT /note="Mb0063, celA1, len: 380 aa. Equivalent to Rv0062, FT len: 380 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 380 aa overlap). Possible celA1, FT cellulase (EC 3.2.1.4), similar to many e.g. FT AB65568.1|AL136058 putative secreted endoglucanase FT (cellulase) from Streptomyces coelicolor (332 aa); FT P07984|GUNA_CELFI ENDOGLUCANASE A PRECURSOR from FT Cellulomonas fimi (449 aa); GUN1_STRHA|P33682 endoglucanase FT 1 precursor (cellulase) from STREPTOMYCES HALSTEDII (321 FT aa), FASTA scores: opt: 702, E(): 1. 2e-27, (38.9% identity FT in 319 aa overlap); etc. SEEMS TO BELONG TO CELLULASE FT FAMILY B (FAMILY 6 OF GLYCOSYL HYDROLASES). Note that FT previously known as celA." FT /db_xref="GOA:Q7U2Y0" FT /db_xref="HSSP:1GZ1" FT /db_xref="InterPro:IPR016288" FT /db_xref="UniProtKB/TrEMBL:Q7U2Y0" FT /protein_id="CAD92925.1" FT /translation="MTRRTGQRWRGTLPGRRPWTRPAPATCRRHLAFVELRHYFARVMS FT SAIGSVARWIVPLLGVAAVASIGVIADPVRVVRAPALILVDAANPLAGKPFYVDPASAA FT MIAARNANPPNAELTSVANTPQSYWLDQAFPPATVGGTVARYTGAAQAAGAMPVLTLYG FT IPHRDCGSYASGGFATGTDYRGWIDAVASGLGSSPATIIVEPDALAMADCLSPDQRQER FT FDLVRYAVDTLTRDPAAAVYVDAGHSRWLSAEAMAARLNDVGVGRARGFSLNVSNFYTT FT DEEIGYGEAISGLTNGSHYVIDTSRNGAGPAPDAPLNWCNPSGRALGAPPTTATAGAHA FT DAYLWIKRPGESDGTCGRGEPQAGRFVSQYAIDLAHNAGQ" FT CDS 66913..68352 FT /transl_table=11 FT /gene="Mb0064" FT /locus_tag="Mb0064" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0064, -, len: 479 aa. Equivalent to Rv0063, len: FT 479 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 479 aa overlap). Possible FT oxidoreductase (EC 1.-.-.-), similar to many e.g. FT HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase from FT Arthrobacter oxidans (458 aa), FASTA scores: opt: 343, E(): FT 3.4e-13, (27.4% identity in 467 aa overlap); FT AAD28454.1|AF127374_9|AF127374|MitR oxidase from FT Streptomyces lavendulae (514 aa); AAF81732.1|AF254925|EncM FT putative FAD-dependent oxygenase from Streptomycesmaritimus FT (464 aa); etc. Also similar to Mycobacterium tuberculosis FT proteins e.g. Rv3107c, Rv1257c, etc. Contains PS00862 FT Oxygen oxidoreductases covalent FAD-binding site." FT /db_xref="GOA:Q7U2X9" FT /db_xref="InterPro:IPR016167" FT /db_xref="UniProtKB/TrEMBL:Q7U2X9" FT /protein_id="CAD92926.1" FT /translation="MAREISRQTFLRGAAGALAAGAVFGSVRATADPAASGWEALSSAL FT GGKVLQPDDGPQFATAKQVFNTNYNGYTPAVIVTPTSQLDVQKAMAFAAANNLKVAPRG FT GGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTVTPATGLYAMHQVLAAAGRGIPT FT GTCPTVGVAGHALGGGLGANSRHAGLLCDQLTSASVVLPSGQAVTASATDHPDLFWALR FT GGGGGNFGVTTSLTFATFPSGDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSWALADA FT TVDPLGTHCRILATCPAGSGGSVAAAIVSAVGTQPTGTENHTFNYLDLVRYLAVGNLNP FT SPLGYVGGSDVFTTITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVSPGATAFP FT WRRQSALVQWYVETSGSPSEATSWLNTAHQAVRAYSVGGYVNYLEVNQPPARYFGPNLS FT RLSAVRQKYDPSRVMFSGLNF" FT CDS 68610..71549 FT /transl_table=11 FT /gene="Mb0065" FT /locus_tag="Mb0065" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0065, -, len: 979 aa. Equivalent to Rv0064, len: FT 979 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 979 aa overlap). Probable conserved FT transmembrane protein, highly similar to NP_301532.1| FT (NC_002677) putative integral membrane protein from FT Mycobacterium leprae (983 aa). Also similar to other FT hypothetical proteins from ARCHAEOGLOBUS FULGIDUS and FT Synecocystis sp. e.g. P72637|D90899 HYPOTHETICAL 117.2 KD FT PROTEIN from SYNECHOCYSTIS SP. (1032 aa), FASTA scores: FT opt: 1004, E(): 3.6e-32, (31.0 % identity in 848 aa FT overlap); and CAC01334.1|AL390968 putative integral FT membrane protein (fragment) from Streptomyces coelicolor FT (815 aa); etc. Also similar to Rv3193c from Mycobacterium FT tuberculosis (992 aa), FASTA score: (50.3% identity in 985 FT aa overlap). Contains probable coiled-coil domain from aa FT 948 to 976." FT /db_xref="GOA:Q7U2X8" FT /db_xref="InterPro:IPR005372" FT /db_xref="UniProtKB/Swiss-Prot:Q7U2X8" FT /protein_id="CAD92927.1" FT /translation="METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWLW FT FGEVGFRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDPVAPL FT RSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIVDPEFGYDIGFFVF FT DLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTTGRGMLTQAARVQLAVFAGAVVL FT LKAVAYWLDRYELLSSGRKEPTFTGAGYTDIHAELPAKLVLVAIAVLCAVSFFTAIFLR FT DLRIPAMAAALLVLSAILVGGLWPLLMEQFSVRPNAADVERPYIQRNIEATREAYRIGG FT DWVQYRSYPGIGTKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFSFAEILDI FT DRYRIDGELQDYIVGVRELSPKSLTGNQTDWINKHIVYTHGNGFVAAPANRVNAAARDA FT ENISDSNSGYPIYAVSDIASLGSGRQVIPVEQPRVYYGEVIAQADPDYAIVGGAPGSAP FT REYDTDTSKYTYTGAGGVSIGNWFNRTVFATKFAQHKFLFSREIGSESKVLIHRDPKER FT VQRVAPWLTTDDNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPVTSPTGIVRQGK FT QVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSEDQIPDELRAHFRY FT PEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNDANATQPPFYVLVGDQQSAQP FT SFRLASAMVGYNREFLSAYISAHSDPANYGKLTVLELPTDTLTQGPQQIQNSMISDTRV FT ASERTLLERSNRIHYGNLLSLPIADGGVLYVEPLYTERISTSPSSSTFPQLSRVLVSVR FT EPRTEGGVRVGYAPTLAESLDQVFGPGTGRVATAPGGDAASAPPPGAGGPAPPQAVPPP FT RTTQPPAAPPRGPDVPPATVAELRETLADLRAVLDRLEKAIDAAETPGG" FT CDS 71848..72249 FT /transl_table=11 FT /gene="Mb0066" FT /locus_tag="Mb0066" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0066, -, len: 133 aa. Equivalent to Rv0065, len: FT 133 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 133 aa overlap). Conserved hypothetical FT protein, similar to several hypothetical proteins from FT Mycobacterium tuberculosis: Rv0960 (127 aa), Rv1720c (129 FT aa), and Rv0549c (137 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U2X7" FT /protein_id="CAD92928.1" FT /translation="MDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVG FT HALRRAVLSDEISEEQARAALDALPYLIDNRYPHSPRLIEYTWQLRHNVTFYDALYVAL FT ATALDVPLLTGDSRLAAAPGLPCEIKLVR" FT CDS complement(72301..74538) FT /transl_table=11 FT /gene="icd2" FT /locus_tag="Mb0067c" FT /product="PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 FT (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) FT (IDP)" FT /EC_number="1.1.1.42" FT /note="Mb0067c, icd2, len: 745 aa. Equivalent to Rv0066c, FT len: 745 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 745 aa overlap). Probable icd2, FT isocitrate dehydrogenase NADP-dependant (EC 1.1.1.42), FT equivalent to NP_302705.1|NC_002677 isocitrate FT dehydrogenase [NADP] from Mycobacterium leprae (746 aa). FT Also highly similar to many members of the monomeric-type FT family of IDH e.g. NP_251314.1|NC_002516 isocitrate FT dehydrogenase from Pseudomonas aeruginosa (741 aa); FT IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from FT Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106, FT E(): 0, (61.4% identity in 735 aa overlap); FT NP_230786.1|NC_002505 isocitrate dehydrogenase [Vibrio FT cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE FT FAMILY OF IDH." FT /db_xref="GOA:Q7U2X6" FT /db_xref="HSSP:1ITW" FT /db_xref="InterPro:IPR004436" FT /db_xref="UniProtKB/TrEMBL:Q7U2X6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92929.1" FT /translation="MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDIS FT VAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQD FT KGYAVPDYPADPNTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHS FT MGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGD FT VIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAF FT AKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGI FT SNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNG FT QFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDI FT WRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGL FT DIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMA FT GGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKT FT LDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVL FT TKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAALEAVQG" FT CDS complement(74656..75225) FT /transl_table=11 FT /gene="Mb0068c" FT /locus_tag="Mb0068c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /note="Mb0068c, -, len: 189 aa. Equivalent to Rv0067c, len: FT 189 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 189 aa overlap). Possible FT transcriptional regulator, highly similar except in FT N-terminus to T44726 probable transcription regulator from FT Mycobacterium leprae (189 aa), FASTA scores: opt: 829, E(): FT 0, (68.3% identity in 189 aa overlap). And similar to FT others, often many members of the tetR family, e.g. T36918 FT probable transcription regulator from Streptomyces FT coelicolor (202 aa); NP_535866.1|NC_003306 transcriptional FT regulator TetR family from Agrobacterium tumefaciens strain FT C58 (Dupont) (194 aa); UIDR_ECOLI|Q59431 uid operon FT repressor (gus operon repressor) from Escherichia coli (196 FT aa), FASTA scores: opt: 200, E(): 7.2e-06, (24.7% identity FT in 186 aa overlap); etc. Also similar to MTCY8D5_28 from FT Mycobacterium tuberculosis cosmid (229 aa), FASTA score: FT (32.7% identity in 168 aa overlap). Contains probable FT helix-turn-helix motif from aa 34 to 55 (Score 1523, +4.37 FT SD)." FT /db_xref="GOA:Q7U2X5" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U2X5" FT /protein_id="CAD92930.1" FT /translation="MAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGV FT GAGTVYRHFPTKEALFQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATD FT RGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQ FT AMQSYNAELAAKVTDVALDGLRANRK" FT CDS 75328..76239 FT /transl_table=11 FT /gene="Mb0069" FT /locus_tag="Mb0069" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0069, -, len: 303 aa. Equivalent to Rv0068, len: FT 303 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 303 aa overlap). Probable oxidoreductase FT (EC 1.-.-.-), equivalent to NP_301343.1|NC_002677 putative FT oxidoreductase from Mycobacterium leprae (304 aa). Also FT highly similar to many e.g. NP_485762.1|NC_003272 probable FT oxidoreductase from Nostoc sp. PCC 7120 (311 aa); FT NP_279536.1|NC_002607|YajO1 probable oxidoreductase from FT Halobacterium sp. NRC-1 (316 aa); OXIR_STRAT|Q03326 FT probable oxidoreductase from Streptomyces antibioticus (298 FT aa), FASTA scores: opt: 430, E(): 1.3e-16, (34.9% identity FT in 295 aa overlap); etc. Also highly similar to MTV037_3 FT and MTV022_13 from Mycobacterium tuberculosis." FT /db_xref="GOA:Q7U2X4" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U2X4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92931.1" FT /translation="MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVLAV FT RNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAGVM FT YTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIHFDD FT LQWERRYRRVAAYGQAKLANLLFTYELQRRLAPGGTTIAVASHPGVSNTELVRNMPRPL FT VAVAAILAPLMQDAELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASSAQSHD FT EQLQRRLWAVSEELTGVVYPVG" FT CDS complement(76264..77649) FT /transl_table=11 FT /gene="sdaA" FT /locus_tag="Mb0070c" FT /product="PROBABLE L-SERINE DEHYDRATASE SDAA (L-SERINE FT DEAMINASE) (SDH) (L-SD)" FT /EC_number="4.3.1.17" FT /note="Mb0070c, sdaA, len: 461 aa. Equivalent to Rv0069c, FT len: 461 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 461 aa overlap). Probable sdaA, FT L-serine dehydratase (EC 4.3.1.17), equivalent to FT NP_302203.1| NC_002677 L-serine dehydratase from FT Mycobacterium leprae (458 aa). Also highly similar to many FT e.g. NP_251133.1|NC_002516 L-serine dehydratase from FT Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO L-SERINE FT DEHYDRATASE from Streptomyces coelicolor (455 aa); FT SDHL_ECOLI|P16095 L-serine dehydratase 1 from Escherichia FT coli (454 aa), FASTA scores: opt: 1381, E(): 0, (51.1% FT identity in 460 aa overlap); etc. BELONGS TO THE FT IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY. FT COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE)." FT /db_xref="GOA:P66774" FT /db_xref="InterPro:IPR005131" FT /db_xref="UniProtKB/Swiss-Prot:P66774" FT /protein_id="CAD92932.1" FT /translation="MTISVFDLFTIGIGPSSSHTVGPMRAANQFVVALRRRGHLDDLEA FT MRVDLFGSLAATGAGHGTMSAILLGLEGCQPETITTEHKERRLAEIAASGVTRIGGVIP FT VPLTERDIDLHPDIVLPTHPNGMTFTAAGPHGRVLATETYFSVGGGFIVTEQTSGNSGQ FT HPCSVALPYVSAQELLDICDRLDVSISEAALRNETCCRTENEVRAALLHLRDVMVECEQ FT RSIAREGLLPGGLRVRRRAKVWYDRLNAEDPTRKPEFAEDWVNLVALAVNEENASGGRV FT VTAPTNGAAGIVPAVLHYAIHYTSAGAGDPDDVTVRFLLTAGAIGSLFKERASISGAEV FT GCQGEVGSAAAMAAAGLAEILGGTPRQVENAAEIAMEHSLGLTCDPIAGLVQIPCIERN FT AISAGKAINAARMALRGDGIHRVTLDQVIDTMRATGADMHTKYKETSAGGLAINVAVNI FT VEC" FT CDS complement(77646..78923) FT /transl_table=11 FT /gene="glyA2" FT /locus_tag="Mb0071c" FT /product="PROBABLE SERINE HYDROXYMETHYLTRANSFERASE GLYA2 FT (SERINE METHYLASE 2) (SHMT 2)" FT /EC_number="2.1.2.1" FT /note="Mb0071c, glyA2, len: 425 aa. Equivalent to Rv0070c, FT len: 425 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 425 aa overlap). Probable glyA2, serine FT hydroxymethyltransferase (EC 2.1.2.1), equivalent to FT NP_302318.1|NC_002677 serine hydroxymethyltransferase from FT Mycobacterium leprae (426 aa). Also highly similar to many FT e.g. O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE from FT Streptomyces coelicolor (420 aa); FT AAK60516.1|AF327063_1|AF327063 serine FT hydroxymethyltransferase from Corynebacterium glutamicum FT (434 aa); GLYA_ECOLI|P00477 serine hydroxymethyltransferase FT from Escherichia coli (417 aa), FASTA scores: opt: 1462, FT E(): 0, (54.3% identity in 416 aa overlap); etc. Also FT highly similar to MTV017_46 from Mycobacterium FT tuberculosis. Contains PS00096 Serine FT hydroxymethyltransferase pyridoxal-phosphate attachment FT site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL FT PHOSPHATE." FT /db_xref="GOA:Q7U2X3" FT /db_xref="InterPro:IPR019798" FT /db_xref="UniProtKB/Swiss-Prot:Q7U2X3" FT /protein_id="CAD92933.1" FT /translation="MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVMQ FT AQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATANAA FT TMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVAEAA FT RTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPVPHAH FT VVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLGHVIAAKATAFKMAAQP FT EFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAEDR FT LAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAAALTATND FT DQLGPLRAQVQRLAARYPLYPELHRT" FT CDS 79513..80229 FT /transl_table=11 FT /gene="Mb0072" FT /locus_tag="Mb0072" FT /product="POSSIBLE MATURASE" FT /note="Mb0072, -, len: 238 aa. Equivalent to Rv0071, len: FT 235 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.7% identity in 238 aa overlap). Possible maturase, FT similar to many proteins of the group II intron maturase FT family e.g. P95451|U77945 MATURASE-RELATED PROTEIN from FT PSEUDOMONAS ALCALIGENES (297 aa), FASTA scores: opt: 395, FT E(): 1.7e-20, (43.5% identity in 147 aa overlap); FT N-terminus of AAD16434.1|AF101076 maturase-related protein FT from Pseudomonas putida (473 aa); N-terminus of FT NP_437373.1|NC_003078 putative reverse FT transcriptasematurase protein from Sinorhizobium meliloti FT (453 aa); etc. Also similar to MLCL581_1 from Mycobacterium FT leprae. Contains 5 VDP repeats at N-terminus, these are FT also found in two Streptococcus plasmid hypothetical FT proteins Q52246|X17092 and Q54942|X66468. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 FT bp insertion (*-cggtggacc) leads to a longer product FT compared to its homolog in Mycobacterium tuberculosis FT strain H37Rv (238 aa versus 235 aa)." FT /db_xref="GOA:Q7U2X2" FT /db_xref="InterPro:IPR000477" FT /db_xref="UniProtKB/TrEMBL:Q7U2X2" FT /protein_id="CAD92934.1" FT /translation="MSSITVSVDPVDPVDPVDPVDPVDPVDAVVAAGSDGLTVARIESE FT IGALEFLNELRTELKSGQFRPQPVRERKIPKPGGLGKVRRLGIPTVADRVVQAALKLVL FT EPIFETDFEPVSYGFRPARRAHDTIAEIHLFGTQEYRWVLDADIKACFDRIDHADLMDR FT VRHRIKDKRVLRLVNWQRIRHRWNWTDVRRWLTDPTGRWHPISADGITLFNPAAVPIRR FT YRYRGNTIPTPWTQAV" FT repeat_region 80272..80586 FT /locus_tag="REP'-1" FT /rpt_family="REP" FT /note="REP'-1, len: 315 nt. Equivalent to REP', len: 315 FT nt, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 315 nt overlap). Probable pseudogene fragment, FT len: 105 aa; similar to many Mycobacterium tuberculosis FT proteins inside REP13E12 elements eg. TR:Q50655 FT (EMBL:Z95390) MTCY13E12.20 (317 aa), FASTA scores; opt: 324 FT z-score: 432.5 E(): 6.8e-17, 43.4% identity in 99 aa FT overlap, but no possible startsite." FT CDS 80660..81709 FT /transl_table=11 FT /gene="Mb0073" FT /locus_tag="Mb0073" FT /product="PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE FT PROTEIN ABC TRANSPORTER" FT /note="Mb0073, -, len: 349 aa. Equivalent to Rv0072, len: FT 349 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 349 aa overlap). Probable FT glutamine-transport transmembrane protein ABC-transporter FT (see citation below), showing weak similarity to FT NP_465894.1|NC_003210 protein similar to putative FT ABC-transporter transmembrane subunit from Listeria FT monocytogenes EGD-e (367 aa); NP_471800.1|NC_003212 protein FT similar to putative ABC-transporter transmembrane subunit FT from Listeria innocua (367 aa); E1204111|AJ003195 MEMBRANE FT SPANNING SUBUNIT DEVC from ANABAENA VARIABILIS (385 aa), FT FASTA scores: opt: 155, E(): 8.1e-07, (22.0% identity in FT 381 aa overlap). Also highly similar to FT Rv2563|Y0A5_MYCTU|Q50735|MTCY9C4.05c from Mycobacterium FT tuberculosis (388 aa), FASTA scores: E(): 0, (76.2% FT identity in 349 aa overlap). Note that supposed act with FT near ORF Rv0073|MTV030.17 ATP-binding protein FT ABC-transporter." FT /db_xref="GOA:Q7U2X1" FT /db_xref="InterPro:IPR003838" FT /db_xref="UniProtKB/TrEMBL:Q7U2X1" FT /protein_id="CAD92935.1" FT /translation="MLFAALRDMQWRKRRLVITIISTGLIFGMTLVLTGLANGFRVEAR FT HTVDSMGVDVFVVRSGAAGPFLGSIPFPDVDLARVAAEPGVMAAAPLGSVGTIMKEGTS FT TRNVTVFGAPEHGPGMPRVSEGRSPSKPDEVAASSTMGRHLGDTVEVGARRLRVVGIVP FT NSTALAKIPNVFLTTEGLQKLAYNGQPNITSIGIIGMPRQLPEGYQTFDRVGAVNDLVR FT PLKVAVNSISIVAVLLWIVAVLIVGSVVYLSALERLRDFAVFKAIGTPTRSIMAGLALQ FT ALVIALLAAVVGVVLAQVLAPLFPMIVAVPVGAYLALPVAAIVIGLFASVAGLKRVVTV FT DPAQAFGGP" FT CDS 81712..82554 FT /transl_table=11 FT /gene="Mb0074" FT /locus_tag="Mb0074" FT /product="PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN FT ABC TRANSPORTER GLNQ" FT /note="Mb0074, -, len: 280 aa. Equivalent to 5' end of FT Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain FT H37Rv, (94.9% identity in 275 aa overlap). Probable FT glutamine-transport ATP-binding protein ABC-transporter FT (see citation below), similar to many ATP-binding proteins FT e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding FT protein from Archaeoglobus fulgidus (231 aa); T34822 FT ABC-transporter ATP binding protein from Streptomyces FT coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC FT transporter ATP-binding protein from Escherichia coli (648 FT aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity FT in 233 aa overlap); etc. Also highly similar to FT Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter FT ATP-binding protein from Mycobacterium tuberculosis (330 FT aa), FASTA scores: E(): 0, (83.3% identity in 330 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), PS00211 ABC transporters family signature, and FT PS00889 Cyclic nucleotide-binding domain signature 2. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS). Note that supposed act with near ORF FT Rv0072|MTV030.16 transmembrane ABC-transporter. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0073 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and FT Mb0075." FT /db_xref="GOA:Q7U2X0" FT /db_xref="HSSP:1F3O" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U2X0" FT /protein_id="CAD92936.1" FT /translation="MGDLSIQNLVVEYYSGGYALRPINGLNLDVAAGSLVMLLGPSGCG FT KTTLLSCLGGILRPKSGAIKFDEVDITTLQGAELANYRRNKVGIVFQAFNLVPSLTAVE FT NVMVPLRSAGMSRRASRRRAEELLARVNLAERMNHRPGDLSGGQQQRVAVARAIALDPP FT LILADEPTAHLDFIQVEEVLRLIRELADGERVVVVATHDSRMLPMADRVVELTPDFAET FT NRPPETVHLQAGEVLFEQSTMGDLIYVVSEGEFEIVHDWPTAVRNWSRLPGRGITSAR" FT CDS 82491..82703 FT /pseudo FT /transl_table=11 FT /gene="Mb0075" FT /locus_tag="Mb0075" FT /product="PROBABLE GLUTAMINE-TRANSPORT PROTEIN ABC FT TRANSPORTER GLNQ" FT /note="Mb0075, -, len: 70 aa. Equivalent to 3' end of FT Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 70 aa overlap). Probable FT glutamine-transport ATP-binding protein ABC-transporter FT (see citation below), similar to many ATP-binding proteins FT e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding FT protein from Archaeoglobus fulgidus (231 aa); T34822 FT ABC-transporter ATP binding protein from Streptomyces FT coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC FT transporter ATP-binding protein from Escherichia coli (648 FT aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity FT in 233 aa overlap); etc. Also highly similar to FT Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter FT ATP-binding protein from Mycobacterium tuberculosis (330 FT aa), FASTA scores: E(): 0, (83.3% identity in 330 aa FT overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop), PS00211 ABC transporters family signature, and FT PS00889 Cyclic nucleotide-binding domain signature 2. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS). Note that supposed act with near ORF FT Rv0072|MTV030.16 transmembrane ABC-transporter. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0073 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a single base FT deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and FT Mb0075." FT /db_xref="PSEUDO:CAD92937.1" FT CDS 82783..84018 FT /transl_table=11 FT /gene="Mb0076" FT /locus_tag="Mb0076" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0076, -, len: 411 aa. Equivalent to Rv0074, len: FT 411 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 411 aa overlap). Conserved hypothetical FT protein, similar to Rv2915c|MTCY338.03c CONSERVED FT HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis, and FT showing some simlarity to various enzymes or hypothetical FT proteins from other organisms, eg NP_243801.1|NC_002570 FT aryldialkylphosphatase from Bacillus halodurans (394 aa); FT NP_421471.1|NC_002696 putativ Xaa-Pro dipeptidase from FT Caulobacter crescentus (429 aa); NP_343436.1|NC_002754 FT Prolidase (Xaa-Pro dipeptidase) (pepQ-like2) from FT Sulfolobus solfataricus (408 aa); Q50432|M91040 ORGANO FT PHOSPHATE ACID ANHYDRASE OPAB from MYCOBACTERIUM SP. (409 FT aa), FASTA scores: opt: 166, E(): 3.9e-11, (31.2% identity FT in 430 aa overlap); etc." FT /db_xref="GOA:Q7U2W9" FT /db_xref="InterPro:IPR006680" FT /db_xref="UniProtKB/TrEMBL:Q7U2W9" FT /protein_id="CAD92938.1" FT /translation="MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISA FT VDFAGSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAGDPHAVLVGRARRHA FT AAALRSGITTIRDLGDRDYAALALREEYRQKTTVGPELVVSGPPLTRSGGHCWFLGGVA FT DSVEELVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGLP FT VTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVWCGMTIPRVYP FT EMPENLVAVVQDGWRNIRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSRHGFTST FT EVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVWRSGTQVP FT LQASAVGYNTPS" FT CDS 84031..85203 FT /transl_table=11 FT /gene="Mb0077" FT /locus_tag="Mb0077" FT /product="PROBABLE AMINOTRANSFERASE" FT /EC_number="2.6.1.-" FT /note="Mb0077, -, len: 390 aa. Equivalent to Rv0075, len: FT 390 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 390 aa overlap). Probable FT aminotransferase (EC 2.6.1.-), similar to many CLASS-II FT PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES (MALY/PATB FT SUBFAMILY) e.g. NP_302217.1|NC_002677 aminotransferase from FT Mycobacterium leprae (402 aa); PATB_BACSU|Q08432 putative FT aminotransferase b from Bacillus subtilis (387 aa), FASTA FT scores: opt: 684, E(): 5.4e-33, (31.3% identity in 384 aa FT overlap); etc. Also similar to several cystathionine FT beta-lyase (beta C-S lyase) e.g. FT AAK69425.1|AF276227_1|AF276227 from Corynebacterium FT glutamicum (368 aa); etc. Also similar to other proteins FT from Mycobacterium tuberculosis e.g. Rv2294, Rv0858c, etc." FT /db_xref="GOA:Q7U2W8" FT /db_xref="InterPro:IPR004839" FT /db_xref="UniProtKB/TrEMBL:Q7U2W8" FT /protein_id="CAD92939.1" FT /translation="MQDSIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPAV FT LDGVRACVDNEEFGYPPLGEDSLPRATADWCRQRYGWCPRPDWVRVVPDVLKGMEVVVE FT FLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQQDSGRYLLDLDALQAAFVRGAG FT SVIICNPNNPLGTAFTEAELRAIVDIAARHGARVIADEIWAPVVYGSRHVAAASVSEAA FT AEVVVTLVSASKGWNLPGLMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRANIAAYH FT HGESWLDELLPYLRANRDHLARALPELAPGVEVNAPDGTYLSWVDFRALALPSEPAEYL FT LSKAKVALSPGIPFGAAVGSGFARLNFATTRAILDRAIEAIAAALRDIID" FT CDS complement(85218..85607) FT /transl_table=11 FT /gene="Mb0078c" FT /locus_tag="Mb0078c" FT /product="PROBABLE MEMBRANE PROTEIN" FT /note="Mb0078c, -, len: 129 aa. Equivalent to Rv0076c, len: FT 129 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 129 aa overlap). Probable membrane FT protein, with membrane-spanning domain at C-terminus." FT /db_xref="UniProtKB/TrEMBL:Q7U2W7" FT /protein_id="CAD92940.1" FT /translation="MPAVTTPSNHWGDERRKLSHQPPVRGQILGRRQARRLSQHFARVG FT VEAPPKRLQEMLLGAPAADEEWTDVKFALIVTQLNHEKRVAKFHRLQRRATHSLICLGL FT VLVALNFLICLAYIFFSLTQHAAAL" FT CDS complement(85671..86501) FT /transl_table=11 FT /gene="Mb0079c" FT /locus_tag="Mb0079c" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0079c, -, len: 276 aa. Equivalent to Rv0077c, len: FT 276 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 276 aa overlap). Possible FT oxidoreductase (EC 1.-.-.-), weakly similar to others e.g. FT CAC44600.1|AL596162 putative oxidoreductase from FT Streptomyces coelicolor (275 aa); P33912|BPA1_STRAU FT NON-HAEM BROMOPEROXIDASE BPO-A1 (BROMIDE PEROXIDASE) (EC FT 1.11.1.-) from Streptomyces aureofaciens (275 aa); FT BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from FT Streptomyces aureofaciens (274 aa), FASTA scores: opt: 230, FT E(): 1.5e-07, (26.1% identity in 249 aa overlap); etc. Also FT similar to MTCY05A6_35 and MTCY1A11_10 from Mycobacterium FT tuberculosis. And shows some similarity in part with FT AAL17935.1|AY054120 putative epoxide hydrolase from FT Mycobacterium smegmatis (203 aa)." FT /db_xref="GOA:Q7U2W6" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7U2W6" FT /protein_id="CAD92941.1" FT /translation="MSTIDISAGTIHYEATGPETGRPVVFVHGYMMGGQLWRRVSERLA FT GRGLRCIAPTWPLGAHPKPLRPGADQTIGGVAGIVADVLAALELKDVVLVGNDTGGVVT FT QLVAVHYPERLGALVLTSCDAFEHFPPPILKPVILAAKSATLFRAAIQVMRAPAARNRA FT YAGLSHHNIDHLTRAWVRPALSNPAIAEDLRQLSLSLRTEVTTAVAARLPEFDKPALIA FT WSADDVFFALENGQRLAATIPRARFEVIEGARTFSMVDSPDRLADQLSTVAVRT" FT CDS 86563..87168 FT /transl_table=11 FT /gene="Mb0080" FT /locus_tag="Mb0080" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0080, -, len: 201 aa. Equivalent to Rv0078, len: FT 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 201 aa overlap). Probable FT transcriptional regulator, equivalent to FT NP_302706.1|NC_002677 putative TetR-family transcriptional FT regulator from Mycobacterium leprae (236 aa), FASTA scores: FT opt: 755, E(): 0, (71.4% identity in 175 aa overlap). Also FT similar to others e.g. NP_103770.1|NC_002678 probable FT transcriptional regulator from Mesorhizobium loti (208 aa); FT NP_384275.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR FT PROTEIN from Sinorhizobium meliloti (197 aa); FT NP_250960.1|NC_002516 probable transcriptional regulator FT from Pseudomonas aeruginosa (196 aa); etc. Also similar to FT TETC_ECOLI|P28815 transposon tn10 tetc protein from FT Escherichia coli (197 aa), FASTA scores: opt: 181, E(): FT 9.7e-05, (24.8% identity in 165 aa overlap). Contains FT probable helix-turn-helix motif from aa 35 to 56 (Score FT 1348, +3.78 SD)." FT /db_xref="GOA:Q7U2W5" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U2W5" FT /protein_id="CAD92942.1" FT /translation="MEIKRRTQEERSAATREALITGARKLWGLRGYAEVGTPEIATEAG FT VTRGAMYHQFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLEVS FT GDPEVRQLVLLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLARQPVRPLAQVL FT IGALDEAAMFIATADDPKRARRETRQVLRRLIDGMLNG" FT CDS complement(87243..87836) FT /transl_table=11 FT /gene="Mb0081c" FT /locus_tag="Mb0081c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0081c, -, len: 197 aa. Equivalent to Rv0078A, len: FT 197 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 197 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2W4" FT /protein_id="CAD92943.1" FT /translation="MNAVESTLRRVAKDLTGLRQRWALVGGFAVSARSEPRFTRDVDIV FT VAVANDDAAESLVRQLLTQQYHLLASVEQDAARRLAAVRLGATADTAANVVVDLLFASC FT GIEPEIAEAAEEIEILPDLVAPVATTAHLIAMKLLARDDDRRPQDRSDLRALVDAASPQ FT DIQDARKAIELITLRGFHRDRDLAAEWTRLAAKW" FT CDS 88239..89060 FT /transl_table=11 FT /gene="Mb0082" FT /locus_tag="Mb0082" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0082, -, len: 273 aa. Equivalent to Rv0079, len: FT 273 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 273 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2W3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92944.1" FT /translation="MEPKRSRLVVCAPEPSHAREFPDVAVFSGGRANASQAERLARAVG FT RVLADRGVTGGARVRLTMANCADGPTLVQINLQVGDTPLRAQAATAGIDDLRPALIRLD FT RQIVRASAQWCPRPWPDRPRRRLTTPAEALVTRRKPVVLRRATPLQAIAAMDAMDYDVH FT LFTDAETGEDAVVYRAGPSGLRLARQHHVFPPGWSRCRAPAGPPVPLIVNSRPTPVLTE FT AAAVDRAREHGLPFLFFTDQATGRGQLLYSRYDGNLGLITPTGDGVADGLA" FT CDS 89057..89515 FT /transl_table=11 FT /gene="Mb0083" FT /locus_tag="Mb0083" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0083, -, len: 152 aa. Equivalent to Rv0080, len: FT 152 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.3% identity in 152 aa overlap). Conserved hypothetical FT protein, similar to several hypothetical proteins from FT Streptomyces coelicolor e.g. SCJ12.26|AL109989|SCJ12_24 FT from Streptomyces coelicolor cosmid J1 (137 aa), FASTA FT scores: opt: 291, E(): 4e-13, (46.5% identity in 129 aa FT overlap); etc." FT /db_xref="UniProtKB/TrEMBL:Q7U2W2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92945.1" FT /translation="MSPGSRRASPQSAREVVELDRDEAMRLLASVDHGRVVFTRAALPA FT IRPVNHLVVDGRVIVRTRLTAKVSVAVRSSADAGVVVAYEADDLDPRRRTGWSVVVTGL FT ATEVSDPEQVARYQRLLHPWVNMAMDTVVAIEPEIVTGIRIVADSRTP" FT CDS 89610..89954 FT /transl_table=11 FT /gene="Mb0084" FT /locus_tag="Mb0084" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0084, -, len: 114 aa. Equivalent to Rv0081, len: FT 114 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 114 aa overlap). Probable FT transcriptional regulator, highly similar to others e.g. FT AL078610|SCH35_52|T36657 probable transcription regulator FT from Streptomyces coelicolor (117 aa), FASTA scores: opt: FT 404, E(): 4.8e-22, (58.2% identity in 110 aa overlap); FT AAG02351.1|AF210249_10|AF210249 metal-dependent regulatory FT protein from Streptomyces verticillus (113 aa); FT NP_435817.1|NC_003037 Putative transcriptional regulator FT from Sinorhizobium meliloti (115 aa); etc." FT /db_xref="GOA:Q7U2W1" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:Q7U2W1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92946.1" FT /translation="MESEPLYKLKAEFFKTLAHPARIRILELLVERDRSVGELLSSDVG FT LESSNLSQQLGVLRRAGVVAARRDGNAMIYSIAAPDIAELLAVARKVLARVLSDRVAVL FT EDLRAGGSAT" FT CDS 89959..90438 FT /transl_table=11 FT /gene="Mb0085" FT /locus_tag="Mb0085" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0085, -, len: 159 aa. Equivalent to Rv0082, len: FT 159 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 159 aa overlap). Probable oxidoreductase FT (EC 1.-.-.-), highly highly similar or similar to other FT various oxidoreductases e.g. NP_143304.1|NC_000961 FT NADH-ubiquinone oxidoreductase subunit from Pyrococcus FT horikoshii (173 aa); NP_126406.1|NC_000868 CO-induced FT hydrogenase related, subunit L from Pyrococcus abyssi (170 FT aa); HYCG_ECOLI|P16433 formate hydrogenlyase subunit 7 from FT Escherichia coli (255 aa), FASTA scores: opt: 442, E(): FT 8e-29, (43.2% identity in 148 aa overlap); etc." FT /db_xref="GOA:Q7U2W0" FT /db_xref="InterPro:IPR006137" FT /db_xref="UniProtKB/TrEMBL:Q7U2W0" FT /protein_id="CAD92947.1" FT /translation="MGWVAKIFRVGRVVEPAAPLPAAIAEPPAGVRGSLQIRHVDAGSC FT NGCEVEISGAFGPVYDAERFGARLVASPRHADALLVTGVVTHNMAGPLRKTLEATPRPR FT VVIACGDCALNRGVFADAYGVVGAVGEVVPVDVEIAGCPPTPAAIMAALRSVTGK" FT CDS 90435..92363 FT /transl_table=11 FT /gene="Mb0086" FT /locus_tag="Mb0086" FT /product="PROBABLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0086, -, len: 642 aa. Equivalent to Rv0083, len: FT 640 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 640 aa overlap). Probable oxidoreductase FT (EC 1.-.-.-), showing some similarity to other various FT oxidoreductases e.g. AAK06855.1|AF335723_1|AF335723 FT hydrogenase-4 component B from Burkholderia pseudomallei FT (668 aa); HYFB_ ECOLI|P23482 hydrogenase-4 component b from FT Escherichia coli strain K12 (672 aa), FASTA scores: opt: FT 995, E(): 0, (32.2% identity in 571 aa overlap); FT AAF13041.1|AF157639_1|AF157639 putative formate FT hydrogenlyase integral membrane subunit from FT Desulfitobacterium dehalogenans (637 aa); etc. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a FT single base transversion (a-t) leads to a slightly longer FT product compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (642 aa versus 640 aa)." FT /db_xref="GOA:Q7U2V9" FT /db_xref="InterPro:IPR003918" FT /db_xref="UniProtKB/TrEMBL:Q7U2V9" FT /protein_id="CAD92948.1" FT /translation="MTAAPTAGGVVTSGVGVAGVGVGLLGMFGPVRVVHVGWLLPLSGV FT HIELDRLGGFFMALTGAVAAPVGCYLIGYVRREHLGRVPMAVVPLFVAAMLLVPAAGSV FT TTFLLAWELMAIASLILVLSEHARPQVRSAGLWYAVMTQLGFIAILVGLVVLAAAGGSD FT RFAGLGAVCDGVRVAVFMLTLVGFGSKAGLVPLHAWLPRAHPEAPSPVSALMSAAMVNL FT GIYGIVRFDLQLLGPGPRWWGLALLAVGGTSALYGVLQASVAADLKRLLAYSTTENMGL FT ITLALGAATLFADTGAYGPASIAAAAAMLHMIAHAAFKSLAFMAAGSVLAATGLRDLDL FT LGGLARRMPATTVFFGVAALGACGLPLGAGFVSEWLLVQSLIHAAPGHDPIVALTTPLA FT VGVVALATGLSVAAMTKAFGIGFLARPRSTQAEAAREAPASMRAGMAIAAGACLVLAVA FT PLLVAPMVRRAAATLPAAQAVKFTGLGAVVRLPAMSGSIAPGVIAAAVLAAALAVAVLA FT RWRFRRRPAPARLPLWACGAADLTVRMQYTATSFAEPLQRVFGDVLRPDTDIEVTHTAE FT SRYMAERITYRTAVADAIEQRLYTPVVGAVAAMAELLRRAHTGSVHRYLAYGALGVLIV FT LVVARCT" FT CDS 92363..93313 FT /transl_table=11 FT /gene="hycD" FT /locus_tag="Mb0087" FT /product="POSSIBLE FORMATE HYDROGENLYASE HYCD (FHL)" FT /EC_number="1.-.-.-" FT /note="Mb0087, hycD, len: 316 aa. Equivalent to Rv0084, FT len: 316 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 316 aa overlap). Possible hycD FT (alternate gene name: hevD), formate hydrogenlyase (EC FT 1.-.-.-), integral membrane protein, similar to others e.g. FT HYCD_ECOLI|P16430 formate hydrogenlyase subunit 4 from FT Escherichia coli (307 aa), FASTA scores: opt: 570, E(): FT 2.1e-26, (33.8% identity in 305 aa overlap); FT AAK06856.1|AF335723_2|AF335723 formate hydrogenlyase FT subunit 4 from Burkholderia pseudomallei (316 aa); FT NP_457244.1|NC_003198 formate hydrogenlyase subunit 4 from FT Salmonella enterica subsp. enterica serovar Typhi (307 aa); FT etc. Also similar to NUOH_ECOLI|P33603 NADH dehydrogenase I FT chain H from Escherichia coli (325 aa), FASTA scores: opt: FT 207, E(): 9.5e-06, (26.5% identity in 260 aa overlap). FT BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY." FT /db_xref="GOA:Q7U2V8" FT /db_xref="InterPro:IPR001694" FT /db_xref="UniProtKB/TrEMBL:Q7U2V8" FT /protein_id="CAD92949.1" FT /translation="MSYLAGAAQIGGVMVGAPLVIGMTRQVRARWEGRAGAGLLQPWRD FT LLKQLGKQQITPAGTTIVFAAAPVIVAGTTLLIAAIAPLVATGSPLDPSADLFAVVGLL FT FLGTVALTLAGIDTGTSFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGALVAS FT TIDHPGHVVSLAGVLAFVALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAGPRLA FT LVEWAAGMRLTVLLALLANLFLPWGIAGAAPTALDVLTGVVAVAAKVAILAVLLATFEV FT FLAKLRLFRVPELLAGSFLLALLAVTAANFFTVGA" FT CDS 93324..93986 FT /transl_table=11 FT /gene="hycP" FT /locus_tag="Mb0088" FT /product="POSSIBLE HYDROGENASE HYCP" FT /EC_number="1.-.-.-" FT /note="Mb0088, hycP, len: 220 aa. Equivalent to Rv0085, FT len: 220 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 220 aa overlap). Possible hycP, FT hydrogenase (EC 1.-.-.-), integral membrane protein, weakly FT similar to P77524|HYFE_ECOLI HYDROGENASE-4 COMPONENT E from FT Escherichia coli (216 aa), FASTA scores: opt: 204, FT E():1.2e-07, (25.5% identity in 216 aa overlap)." FT /db_xref="GOA:P64682" FT /db_xref="UniProtKB/Swiss-Prot:P64682" FT /protein_id="CAD92950.1" FT /translation="MSNANFSILVDFAAGGLVLASVLIVWRRDLRAIVRLLAWQGAALA FT AIPLLRGIRDNDRALIAVGIAVLALRALVLPWLLARAVGAEAAAQREATPLVNTASSLL FT ITAGLTLTAFAITQPVVNLEPGVTINAVPAAFAVVLIALFVMTTRLHAVSQAAGFLMLD FT NGIAATAFLLTAGVPLIVELGASLDVLFAVIVIGVLTGRLRRIFGDADLDKLRELRD" FT CDS 93986..95452 FT /transl_table=11 FT /gene="hycQ" FT /locus_tag="Mb0089" FT /product="POSSIBLE HYDROGENASE HYCQ" FT /EC_number="1.-.-.-" FT /note="Mb0089, hycQ, len: 488 aa. Equivalent to Rv0086, FT len: 488 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 488 aa overlap). Possible hycQ, FT hydrogenase (EC 1.-.-.-), integral membrane protein, weakly FT similar to P77437|HYFF_ECOLI HYDROGENASE-4 COMPONENT F from FT Escherichia coli (526 aa), FASTA scores: opt: 948, E(): 0, FT (35.9% identity in 493 aa overlap); and FT AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B FT from Burkholderia pseudomallei (668 aa). Also similar to FT d9087711 & NUOL_ECOLI|P33607 NADH dehydrogenase I chain L FT from Escherichia coli (613 aa), FASTA scores: opt: 360, FT E():3.2e-13, (27.9% identity in 488 aa overlap); and to FT NUON_ECOLI|P33608 NADH dehydrogenase I chain N from FT Escherichia coli (425 aa), FASTA scores: opt: 375, E(): FT 3.9e-14, (25.0% identity in 432 aa overlap)." FT /db_xref="GOA:Q7U2V7" FT /db_xref="InterPro:IPR003916" FT /db_xref="UniProtKB/TrEMBL:Q7U2V7" FT /protein_id="CAD92951.1" FT /translation="MTGLLLAAILAPLAASIASLITGWRRTTATLTALSATTVLACAVA FT MGFWMGSGAQFGLGGLLRADALTVVMLVVIGIVGTLATAASIGYIDTELAHGHIDGRSA FT RLYGVLTPAFLCATVLAVCANNIGVIWVAIEATTVITAFLVGHRRTRTALEATWKYVVI FT CSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLLIGYG FT AKAGLFPFHTWLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAYLRNGL FT LVVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLLHVLAHG FT IGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVGLIVLLGLPPFAMFASEL FT AIARSLANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPAITVPATAAAALM FT VGIVVSAALGITAGPLADLLGIAASNVGLP" FT CDS 95449..96927 FT /transl_table=11 FT /gene="hycE" FT /locus_tag="Mb0090" FT /product="POSSIBLE FORMATE HYDROGENASE HYCQ (FHL)" FT /EC_number="1.-.-.-" FT /note="Mb0090, hycE, len: 492 aa. Equivalent to Rv0087, FT len: 492 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 492 aa overlap). Possible hycE FT (alternate gene name: hevE), formate hydrogenlyase (EC FT 1.-.-.-), similar to others e.g. HYCE_ECOLI|P16431 formate FT hydrogenlyase subunit 5 from Escherichia coli (569 aa), FT FASTA scores: opt: 680, E(): 1.8e-38, (31.2% identity in FT 449 aa overlap); NP_457243.1|NC_003198 formate FT hydrogenlyase subunit 5 from Salmonella enterica subsp. FT enterica serovar Typhi (569 aa); NP_275541.1|NC_000916 FT formate hydrogenlyase subunit 5 from Methanothermobacter FT thermautotrophicus (370 aa); etc. Also some similarity with FT NUOD_ECOLI|P33600 NADH dehydrogenase I chain D from FT Escherichia coli (407 aa), FASTA scores: opt: 245, E(): FT 8.9e-10, (24.5% identity in 368 aa overlap). BELONGS TO THE FT COMPLEX I 49 kDa SUBUNIT FAMILY." FT /db_xref="GOA:Q7U2V6" FT /db_xref="InterPro:IPR020396" FT /db_xref="UniProtKB/TrEMBL:Q7U2V6" FT /protein_id="CAD92952.1" FT /translation="MMSASWLRHRVSERGLIATAEQLWADSFRLALVAAHDDGDSLRVV FT YLFLAGYPDRRVELEYVVPADNPEIRSLAYLSFPAGRFEREMADLYGIRPVGHPKPRRL FT VRHAHWPDWHPMRTDAGPAPEFTDTGAFPFLAVEGPGVYEIPVGPVHAGLIEPGHFRFS FT VAGETIVRLKARLWFVHRGIEKLFHGRPATAAVDLAERISGDTSAAHALAHSLAIEDAL FT GIELPHEIHRLRALIVELERLYNHAADLGALANDVGYSLANAHAQRIRENLLRRNAAVT FT GHRLLRGAIRAGGVALRALPDTDELAALAVDLAEVATLTLANSVVYDRFAGTAVLHPDD FT ASALGCLGYVARASGLRSDARVEHPTIVLPITEIGAPDGDVLARYTVRRDEFAASAALA FT QHIVESHTGPIEYAATLHPVGAPSSGIGIVEGWRGTIVHRVEIDVDGRITRAKVVDPSW FT FNWPALPVAMADTIVPDFPLANKSFNQSYAGNDL" FT CDS 96962..97636 FT /transl_table=11 FT /gene="Mb0091" FT /locus_tag="Mb0091" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0091, -, len: 224 aa. Equivalent to Rv0088, len: FT 224 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 224 aa overlap). Hypothetical unknown FT protein." FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/Swiss-Prot:P0A5C4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92953.1" FT /translation="MSVYKHAPSRVRLRQTRSTVVKGRSGSLSWRRVRTGDLGLAVWGG FT REEYRAVKPGTPGIQPKGDMMTVTVVDAGPGRVSRSVEVAAPAAELFAIVADPRRHREL FT DGSGTVRGNIKVPAKLVVGSKFSTKMKLFGLPYRITSRVTALKPNELVEWSHPLGHRWR FT WEFESLSPTLTRVTETFDYHAAGAIKNGLKFYEMTGFAKSNAAGIEATLAKLSDQYARG FT RA" FT CDS 97793..98386 FT /transl_table=11 FT /gene="Mb0092" FT /locus_tag="Mb0092" FT /product="POSSIBLE METHYLTRANSFERASE/METHYLASE" FT /EC_number="2.1.1.-" FT /note="Mb0092, -, len: 197 aa. Equivalent to Rv0089, len: FT 197 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 197 aa overlap). Possible FT methyltransferase (EC 2.1.1.-), showing some weak FT similarity to others e.g. NP_299749.1|NC_002488 FT 3-demethylubiquinone-9 3-methyltransferase from Xylella FT fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative FT methyltransferase from Streptomyces coelicolor (285 aa); FT NP_111415.1|NC_002689 Predicted SAM-dependent FT methyltransferase from Thermoplasma volcanium (245 aa); FT etc. Also some similarity with many biotin biosynthesis FT proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS FT PROTEIN from Escherichia coli (251 aa), FASTA scores: opt: FT 202, E(): 4.5e-07, (39.0% identity in 118 aa overlap); etc. FT BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY." FT /db_xref="GOA:P65347" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P65347" FT /protein_id="CAD92954.1" FT /translation="MDQPWNANIHYDALLDAMVPLGTQCVLDVGCGDGLLAARLARRIP FT YVTAVDIDAPVLRRAQTRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIEDTRTA FT LSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHSAPIKWPPPQ FT TLHELRSHVRALLPGACIRRLLYGRVLVTWRAPV" FT CDS 98515..99285 FT /transl_table=11 FT /gene="Mb0093" FT /locus_tag="Mb0093" FT /product="POSSIBLE MEMBRANE PROTEIN" FT /note="Mb0093, -, len: 256 aa. Equivalent to Rv0090, len: FT 256 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 256 aa overlap). Possible membrane FT protein." FT /db_xref="GOA:P64684" FT /db_xref="InterPro:IPR014511" FT /db_xref="UniProtKB/Swiss-Prot:P64684" FT /protein_id="CAD92955.1" FT /translation="MAKNQNRIRNRWELITCGLGGHVTYAPDDAALAARLRASTGLGEV FT WRCLRCGDFALGGPQGRGAPEDAPLIMRGKALRQAIIIRALGVERLVRALVLALAAWAV FT WEFRGARGAIQATLDRDLPVLRAAGFKVDQMTVIHALEKALAAKPSTLALITGMLAAYA FT VLQAVEGVGLWLLKRWGEYFAVVATSIFLPLEVHDLAKGITTTRVVTFSINVAAVVYLL FT ISKRLFGVRGGRKAYDVERRGEQLLDLERAAMLT" FT CDS 99719..100486 FT /transl_table=11 FT /gene="mtn" FT /locus_tag="Mb0094" FT /product="PROBABLE BIFUNCTIONAL MTA/SAH NUCLEOSIDASE MTN: FT 5'-METHYLTHIOADENOSINE NUCLEOSIDASE + FT S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE" FT /EC_number="3.2.2.16" FT /EC_number="3.2.2.9" FT /note="Mb0094, mtn, len: 255 aa. Equivalent to Rv0091, len: FT 255 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 255 aa overlap). Probable mtn FT (alternate gene name: pfs), MTA/SAH nucleosidase, including FT 5'-methylthioadenosine nucleosidase (EC 3.2.2.16) and FT S-adenosylhomocysteine nucleosidase (EC 3.2.2.9), similar FT to others e.g. NP_521493.1|NC_003295 PROBABLE BIFUNCTIONAL FT PROTEIN (MTA/SAH NUCLEOSIDASE) (P46): FT 5'-METHYLTHIOADENOSINE NUCLEOSIDASE AND FT S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE from Ralstonia FT solanacearum (261 aa); AAC45731.1|U55214 Pfs from Treponema FT pallidum (249 aa); P96122|MTN_TREPA MTA/SAH NUCLEOSIDASE FT from Treponema pallidum (269 aa); PFS_ECOLI|P24247 pfs FT protein (p46) from Escherichia coli (232 aa), FASTA scores: FT opt: 214, E(): 3.8e-08, (30.5% identity in 246 aa overlap); FT etc. BELONGS TO THE MTN FAMILY." FT /db_xref="GOA:P67657" FT /db_xref="HSSP:1JYS" FT /db_xref="InterPro:IPR018017" FT /db_xref="UniProtKB/Swiss-Prot:P67657" FT /protein_id="CAD92956.1" FT /translation="MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRV FT VLAAAGMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQHDFGL FT LTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAPLSTAAGGGGRQPR FT IYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDIPWLVIRALSDLA FT GADSGVDFNRFVGEVAASSARVLLRLLPVLTAC" FT CDS 100618..102903 FT /transl_table=11 FT /gene="ctpA" FT /locus_tag="Mb0095" FT /product="PROBABLE CATION TRANSPORTER P-TYPE ATPASE A CTPA" FT /EC_number="3.6.3.-" FT /note="Mb0095, ctpA, len: 761 aa. Equivalent to Rv0092, FT len: 761 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 761 aa overlap). Probable ctpA, FT cation-transporting P-type ATPase A (transmembrane protein) FT (EC 3.6.3.-), highly similar to others e.g. FT CTPA_MYCLE|P46839 cation-transporting P-type ATPase A from FT Mycobacterium leprae (780 aa), FASTA scores: opt: 3454, FT E(): 0, (74.4% identity in 741 aa overlap); FT CAB66270.1|AL136519 probable cation-transporting P-type FT ATPase from Streptomyces coelicolor (760 aa); FT NP_391230.1|NC_000964 protein similar to heavy FT metal-transporting ATPase from Bacillus subtilis (803 aa); FT etc. Also highly similar to MTCY251.22c from Mycobacterium FT tuberculosis, FASTA score: (68.3% identity in 742 aa FT overlap). Contains PS01047 Heavy-metal-associated domain, FT and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO FT THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), FT SUBFAMILY IB." FT /db_xref="GOA:Q7U2V5" FT /db_xref="HSSP:1OQ3" FT /db_xref="InterPro:IPR008250" FT /db_xref="UniProtKB/TrEMBL:Q7U2V5" FT /protein_id="CAD92957.1" FT /translation="MTAAVTGEHHASVQRIQLRISGMSCSACAHRVESTLNKLPGVRAA FT VNFGTRVATIDTSEAVDAAALCQAVRRAGYQADLCTDDGRSASDPDADHARQLLIRLAI FT AAVLFVPVADLSVMFGVVPATRFTGWQWVLSALALPVVTWAAWPFHRVAMRNARHHAAS FT METLISVGITAATIWSLYTVFGNHSPIERSGIWQALLGSDAIYFEVAAGVTVFVLVGRY FT FEARAKSQAGSALRALAALSAKEVAVLLPDGSEMVIPADELKEQQRFVVRPGQIVAADG FT LAVDGSAAVDMSAMTGEAKPTRVRPGGQVIGGTTVLDGRLIVEAAAVGADTQFAGMVRL FT VEQAQAQKADAQRLADRISSVFVPAVLVIAALTAAGWLIAGGQPDRAVSAALAVLVIAC FT PCALGLATPTAMMVASGRGAQLGIFLKGYKSLEATRAVDTVVFDKTGTLTTGRLQVSAV FT TAAPGWEADQVLALAATVEAASEHSVALAIAAATTRRDAVTDFRAIPGRGVSGTVSGRA FT VRVGKPSWIGSSSCHPNMRAARRHAESLGETAVFVEVDGEPCGVIAVADAVKDSARDAV FT AALADRGLRTMLLTGDNPESAAAVATRVGIDEVIADILPEGKVDVIEQLRDRGHVVAMV FT GDGINDGPALARADLGMAIGRGTDVAIGAADIILVRDHLDVVPLALDLARATMRTVKLN FT MVWAFGYNIAAIPVAAAGLLNPLVAGAAMAFSSFFVVSNSLRLRKFGRYPLGCGTVGGP FT QMTAPSSA" FT CDS complement(102850..103698) FT /transl_table=11 FT /gene="Mb0096c" FT /locus_tag="Mb0096c" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0096c, -, len: 282 aa. Equivalent to Rv0093c, len: FT 282 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 282 aa overlap). Probable conserved FT membrane protein, equivalent only to CAC30943.1|AL583924 FT probable integral membrane protein from Mycobacterium FT leprae (237 aa)." FT /db_xref="UniProtKB/TrEMBL:Q7U2V4" FT /protein_id="CAD92958.1" FT /translation="MLAQATTAGSFNHHASTVLQGRRGVPAAMWSEPAGAIRRHCATID FT GMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAESRP FT VVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPTGAG FT THLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAVSTTR FT ILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWPTDGSA FT A" FT CDS complement(103745..104698) FT /transl_table=11 FT /gene="Mb0097c" FT /locus_tag="Mb0097c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0097c, -, len: 317 aa. Equivalent to Rv0094c, len: FT 317 aa, from Mycobacterium tuberculosis strain H37Rv, FT (97.8% identity in 317 aa overlap). Member of 13E12 repeat FT family, showing some similarity to U15187|MLU15187_7 from FT Mycobacterium leprae (94 aa), FASTA score: (49.4% identity FT in 79 aa overlap)." FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:Q7U2V3" FT /protein_id="CAD92959.1" FT /translation="MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTER FT ARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTPDA FT AAIDRDTRSQAQRNHDGLLAGLRALIASGELGQHNGLPVSIVVTTTLTDLQTGAGKGFT FT GGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFAN FT DRGCTKPGCDAPAYHSQAHHVTGWTSTGRTDITDLTLACDPDNRLAEKGWTTRKNTHGH FT TEWLPPPHLDHGQPWTNTFHHPERFLHNQDDDDKPD" FT repeat_region complement(103748..105251) FT /locus_tag="REP-2" FT /rpt_family="REP" FT /note="REP-2, len: 1504 nt. Equivalent to REP, len: 1503 FT nt, from Mycobacterium tuberculosis strain H37Rv, (97.0% FT identity in 1504 nt overlap). REP251, member of REP13E12 FT family." FT CDS complement(104469..105251) FT /transl_table=11 FT /gene="Mb0098c" FT /locus_tag="Mb0098c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0098c, -, len: 260 aa. Equivalent to Rv1588 and FT Rv0095c, len: 222 aa and 136 aa, from Mycobacterium FT tuberculosis strain H37Rv, (98.2% identity in 222 aa FT overlap and 92.5% identity in 134 aa overlap). Member of FT 13E12 repeat, also partially similar to AF0418|AF041819_8 FT from Mycobacterium bovis BCG (222 aa), FASTA score: (89.6% FT identity in 96 aa overlap). REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium tuberculosis strain H37Rv, Rv0095c and FT Rv1588 exist as separate genes in their respective FT positions. In Mycobacterium bovis, a 73 bp substitution FT leads to a single combined gene." FT /db_xref="UniProtKB/TrEMBL:Q7U2V2" FT /protein_id="CAD92960.1" FT /translation="MRYLPVSTRRIWVNPLCHFSFTVISGALFVSARRYDSNMLANSRE FT ELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHTLINQLDTQAS FT EEELGGTLCCALANRLRITKPDAALRIADAADLGPRRALTGEPLAPQLTATATAQRQGL FT IGEAHIKVIRALFRPPARRGGCVHPPGRRSRPGRQSRSISSRRAGPLRPAGHGLATPRR FT RPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL" FT CDS 105360..106751 FT /transl_table=11 FT /gene="PPE1" FT /locus_tag="Mb0099" FT /product="PPE FAMILY PROTEIN" FT /note="Mb0099, PPE1, len: 463 aa. Equivalent to Rv0096, FT len: 463 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 463 aa overlap). Member of the FT Mycobacterium tuberculosis PPE family, similar to many e.g. FT Z46257|MLACEA_3 aceA gene for isocitrate L from M. leprae FT (438 aa), FASTA scores: opt: 1207, E(): 0, (55.3% identity FT in 380 aa overlap). Also similar to Z97559|MTCY261_19 from FT Mycobacterium tuberculosis (473 aa), FASTA score: (40.2% FT identity in 478 aa overlap); YHS6_MYCTU|P42611 hypothetical FT 50.6 kd protein (517 aa), FASTA scores: opt: 365, E(): FT 4.6e-12, (37.6% identity in 178 aa overlap). Also similar FT to MTCY274.23c from M. tuberculosis FASTA score: (31.1% FT identity in 383 overlap). Some similarity also to FT MTCY31.06c and MTCY48.17 and other mycobacterial PPE family FT proteins." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q7U2V1" FT /protein_id="CAD92961.1" FT /translation="MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQL FT LGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMPTP FT AELAANHAIHGVLIATNFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATVAVP FT STQPAPPIRAPGGDAADTWLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSPAVTV FT VLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLLPIAAA FT LGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLA FT PPGVSSGPKAGTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRDEFLDATA FT TVDAATDVPAPANAAGSQGAGTLGFAGTAPTTSGAAAGMVQLSSHSTSTTVPLLPTTWT FT TDAEQ" FT CDS 106770..107639 FT /transl_table=11 FT /gene="Mb0100" FT /locus_tag="Mb0100" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0100, -, len: 289 aa. Equivalent to Rv0097, len: FT 289 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 289 aa overlap). Possible FT oxidoreductase (EC 1.-.-.-), equivalent to FT NP_302343.1|NC_002677 putative oxidoreductase from FT Mycobacterium leprae (289 aa). Also highly similar to FT BAB69377.1|AB070955 putative oxidoreductase from FT Streptomyces avermitilis (296 aa); and weakly similar to FT others e.g. NP_518867.1|NC_003295 PUTATIVE FT ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE FT OXIDOREDUCTASE PROTEIN from Ralstonia solanacearum (301 FT aa); NP_286110.1|NC_002655 taurine dioxygenase FT (2-oxoglutarate-dependent) from Escherichia coli strain FT O157:H7 (283 aa); NP_252624.1|NC_002516 taurine dioxygenase FT from Pseudomonas aeruginosa (277 aa); ECAE00014310 (283 FT aa), FASTA scores: opt: 304, E(): 2.6e-13, (27.8% identity FT in 288 aa overlap); TFDA_ALCEU|P10088 FT 2,4-dichlorophenoxyacetate monooxygenase from A. eutropha FT (287 aa), FASTA scores: opt: 188, E(): 3.5e-06, (26.6% FT identity in 188 aa overlap); etc. Contains PS00077 FT Cytochrome c oxidase subunit I, copper B binding region FT signature." FT /db_xref="GOA:P67756" FT /db_xref="HSSP:1GY9" FT /db_xref="InterPro:IPR003819" FT /db_xref="UniProtKB/Swiss-Prot:P67756" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92962.1" FT /translation="MTLKVKGEGLGAQVTGVDPKNLDDITTDEIRDIVYTNKLVVLKDV FT HPSPREFIKLGRIIGQIVPYYEPMYHHEDHPEIFVSSTEEGQGVPKTGAFWHIDYMFMP FT EPFAFSMVLPLAVPGHDRGTYFIDLARVWQSLPAAKRDPARGTVSTHDPRRHIKIRPSD FT VYRPIGEVWDEINRTTPPIKWPTVIRHPKTGQEILYICATGTTKIEDKDGNPVDPEVLQ FT ELMAATGQLDPEYQSPFIHTQHYQVGDIILWDNRVLMHRAKHGSAAGTLTTYRLTMLDG FT LKTPGYAA" FT CDS 107636..108187 FT /transl_table=11 FT /gene="Mb0101" FT /locus_tag="Mb0101" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0101, -, len: 183 aa. Equivalent to Rv0098, len: FT 183 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 183 aa overlap). Conserved hypothetical FT protein, equivalent to CAC30948.1|AL583924 conserved FT hypothetical protein from Mycobacterium leprae (183 aa). FT Also some similarity with BAB69378.1|AB070955 hypothetical FT protein from Streptomyces avermitilis (172 aa)." FT /db_xref="UniProtKB/Swiss-Prot:P64686" FT /protein_id="CAD92963.1" FT /translation="MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDAQ FT YSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRG FT WSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEF FT WDENGGAASGEIELAALNIP" FT CDS 108192..109814 FT /transl_table=11 FT /gene="fadD10" FT /locus_tag="Mb0102" FT /product="POSSIBLE FATTY-ACID-COA LIGASE FADD10 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb0102, fadD10, len: 540 aa. Equivalent to Rv0099, FT len: 540 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 540 aa overlap). Possible fadD10, FT fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to FT MLACEA_4|Q50176 LONG CHAIN FATTY ACID-COA LIGASE from FT Mycobacterium leprae (532 aa), FASTA scores: opt: 2580, FT E(): 0, (74.6% identity in 531 aa overlap). Also similar to FT many e.g. BAB69379.1|AB070955 long-chain fatty acid--CoA FT ligase from Streptomyces avermitilis (518 aa); FT NP_419782.1|NC_002696 putativ long-chain-fatty-acid--CoA FT ligase from Caulobacter crescentus (530 aa); FT NP_435326.1|NC_003037 probable long chain fatty acid CoA FT ligase from Sinorhizobium meliloti (508 aa); etc. Also FT similar to ACSA_BACSU|P39062 acetyl-coenzyme A synthetase FT from Bacillus subtilis (572 aa), FASTA scores: opt: 415, FT E(): 9.8e-20, (27.1% identity in 539 aa overlap). Contains FT PS00455 putative AMP-binding domain signature. BELONGS TO FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY." FT /db_xref="GOA:Q7U2V0" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U2V0" FT /protein_id="CAD92964.1" FT /translation="MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYR FT ELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAA FT IERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGN FT ADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLP FT ATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSA FT NATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIE FT AGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVL FT IDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEI FT PDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQS FT GKVMRASLAAAATADKARVVVRG" FT CDS 109819..110055 FT /transl_table=11 FT /gene="Mb0103" FT /locus_tag="Mb0103" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0103, -, len: 78 aa. Equivalent to Rv0100, FT (MTCY251.19), len: 78 aa. Conserved hypothetical protein, FT equivalent only to CAC30950.1|AL583924 conserved FT hypothetical protein from Mycobacterium leprae (78 aa)." FT /db_xref="GOA:P64688" FT /db_xref="InterPro:IPR006162" FT /db_xref="UniProtKB/Swiss-Prot:P64688" FT /protein_id="CAD92965.1" FT /translation="MRDRILAAVCDVLYIDEADLIDGDETDLRDLGLDSVRFVLLMKQL FT GVNRQSELPSRLAANPSIAGWLRELEAVCTEFG" FT CDS 110037..117575 FT /transl_table=11 FT /gene="nrp" FT /locus_tag="Mb0104" FT /product="PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE FT SYNTHASE)" FT /EC_number="6.-.-.-" FT /note="Mb0104, nrp, len: 2512 aa. Equivalent to Rv0101, FT len: 2512 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 2512 aa overlap). Probable nrp, peptide FT synthetase (EC 6.-.-.-), similar to others e.g. FT AAD44234.1|AF143772_40|PstB peptide synthetase from FT Mycobacterium avium (2552 aa); 7476034|S77657 cyclic FT peptide synthetase from Mycobacterium leprae (1401 aa), FT FASTA scores: opt: 4268, E(): 0, (65.7% identity in 1091 aa FT overlap); part of CAB55600.1|AJ238027 peptide synthetase FT from Mycobacterium smegmatis (5990). Also similar to e.g. FT AAD56240.1|AF184977_1|AF184977 DhbF protein from Bacillus FT subtilis (2378 aa); SRF1_BACSU|P27206 surfactin synthetase FT subunit 1 (3587 aa), FASTA scores: opt: 1708, E(): 0, FT (30.6% identity in 1633 aa overlap): etc. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop), 2 x PS00455 Putative FT AMP-binding domain signature, and PS00012 FT Phosphopantetheine attachment site. BELONGS TO THE FT ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. THOUGHT TO BE NOT FT INVOLVED IN MYCOBACTIN BIOSYNTHESIS (see citation below)." FT /db_xref="GOA:Q7U2U9" FT /db_xref="HSSP:1DNY" FT /db_xref="InterPro:IPR010080" FT /db_xref="UniProtKB/TrEMBL:Q7U2U9" FT /protein_id="CAD92966.1" FT /translation="MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRLELARFLAA FT LHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADEHLQSTWCSGILGKPLVR FT HTVHTDPNGYVTGLDVHTHHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLRE FT AHRRETAKVEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNA FT FDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVATCLVN FT SVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVEALTLNF FT IREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWNRADLPACKTHPK FT VAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQGDWPARQPSTPAWFLDSARGV FT HQFLGRRRFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDTAD FT EISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTAY FT IMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTSDISVEEIFGGA FT ACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADGDAIDAIGRSRLRQ FT IVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIVCDQTTMDGALLRL FT GRPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDA FT EGFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTRE FT GEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQWSAAGLNTAE FT TGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILPETRRYLGWRLSLLDLIGA FT DTAANLADYAPTPDAPTGEDRFRPLVAAQRPAAIPLSFAQRRLWFLDQLQRPAPVYNMA FT VALRLRGYLDTEALGAAVADVVGRHESLRTVFPAVDGVPRQLVIEARRADLGCDIVDAT FT AWPADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEHVLVAVAHHIAADGWSVAPLT FT ADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAG FT MPERLRLPTARPYPPVADQRGASLVVDWPASVQQQVRRIARQHNATSFMVVAAGLAVLL FT SKLSGSPDVAVGFPIAGRSDPALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVRARSLA FT AYENQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTA FT RMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPERTV FT SSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARIPEAEAVCCGDASMTY FT RELDEASNRLAHRLAGCGAGPGECVALLFERCAPAVVAMVAVLKTGAAYLPIDPANPPP FT RVAFMLGDAVPVAAVTTAGLRSRLAGHDLPIIDVVDALAAYPGTPPPMPAAVNLAYILY FT TSGTTGEPKGVGITHRNVTRLFASLPARLSAAQVWSQCHSYGFDASAWEIWGALLGGGR FT LVIVPESVAASPNDFHGLLVAEHVSVLTQTPAAVAMLPTQGLESVALVVAGEACPAALV FT DRWAPGRVMLNAYGPTETTICAAISAPLRPGSGMPPIGVPVSGAALFVLDSWLRPVPAG FT VAGELYIAGAGVGVGYWRRAGLTASRFVACPFGGSGARMYRTGDLVCWRADGQLEFLGR FT TDDQVKIRGYRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPA FT GLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGDTNGYRAPAGPVEKT FT VAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAAINTTLNADLPVRALLHASSTRGL FT SQLLGRDARPTSDPRLVSVHGDNPTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTV FT LLTGATGFLGRYLVLELLRRLDVDGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFK FT ELAADRLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPNVAGT FT AELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGYGTSK FT WAGEVLLREANDLCALPVAVFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPRSF FT YEPDSEGNRQRAHFDGLPVTFVAEAIAVLGARVAGSSLAGFATYHVMNPHDDGIGLDEY FT VDWLIEAGYPIRRIDDFAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQRLQPLKPTR FT GCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL" FT CDS 117750..119735 FT /transl_table=11 FT /gene="Mb0105" FT /locus_tag="Mb0105" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0105, -, len: 661 aa. Equivalent to Rv0102, len: FT 661 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 661 aa overlap). Probable conserved FT integral membrane protein, highly similar to FT P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible FT membrane protein from Mycobacterium leprae (659 aa), FASTA FT scores: opt: 3107, E(): 0, (70.2% identity in 662 aa FT overlap). Also similar to others e.g. CAC01497.1|AL391017 FT putative integral membrane protein from Streptomyces FT coelicolor (316 aa); etc. Contains PS00343 Gram-positive FT cocci surface proteins 'anchoring' hexapeptide." FT /db_xref="GOA:P64690" FT /db_xref="InterPro:IPR019108" FT /db_xref="UniProtKB/Swiss-Prot:P64690" FT /protein_id="CAD92967.1" FT /translation="MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLVS FT GARRYAEAGNPYPGAFVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAAAF FT RIHLLAERVSGLWLGLAATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWIVAA FT ICALVVATALRLYTRWLGHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVFAVAF FT ATLTGLKIAAALAGTTPSRAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFARLGLL FT AGVILTSVWLFDCWRLLVRPPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAPRFLTHA FT FTAWDVFLGYELPQPPTIARVLTVWRFDSLIGAAGVVLAIGYAAGFAALRRRGNSWPVG FT RLIAWLTGCAALVFTSGSGVRAYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRVL FT PVTGDGRPPGAREWLTWLLHSRVTTFLSHPITAFVLFVASPYIVYFTPLFDTFVRYHWG FT HEFMAIHFLVVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFGIALMTMSSTV FT GATFYRSVNLPWLSSIIADQHLGGGIAWSLTELPVIMVIVALVTQWARQDRRVASREDR FT HADSDYADDELEAYNAMLRELSRMRR" FT CDS complement(119951..122209) FT /transl_table=11 FT /gene="ctpB" FT /locus_tag="Mb0106c" FT /product="PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB" FT /EC_number="3.6.3.-" FT /note="Mb0106c, ctpB, len: 752 aa. Equivalent to Rv0103c, FT len: 752 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 752 aa overlap). Probable ctpB, FT cation-transporting P-type ATPase B (transmembrane protein) FT (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840 FT cation-transporting P-type ATPase B from Mycobacterium FT leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5% FT identity in 752 aa overlap). Also highly similar to others FT e.g. CAB96031.1|AL360055 putative metal transporter ATPase FT from Streptomyces coelicolor (753 aa); FT NP_241423.1|NC_002570 copper-transporting ATPase from FT Bacillus halodurans (806 aa); etc. Also highly similar to FT Z46257|MLACEA_7 aceA gene for isocitrate L from FT Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, FT E():0, (76.5% identity in 752 aa overlap). And similar to FT MTCY251.11 from Mycobacterium tuberculosis, FASTA score: FT (68.3% identity in 742 aa overlap). Contains PS01047 FT Heavy-metal-associated domain, PS00154 E1-E2 ATPases FT phosphorylation site. BELONGS TO THE CATION TRANSPORT FT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB." FT /db_xref="GOA:P59947" FT /db_xref="InterPro:IPR000579" FT /db_xref="UniProtKB/Swiss-Prot:P59947" FT /protein_id="CAD92968.1" FT /translation="MAAPVVGDADLQSVRRIRLDVSGMSCAACASRVETKLNKIPGVRA FT SVNFATRVATIDAVGMAADELCGVVEKAGYHAAPHTETTVLDKRTKDPDGAHARRLLRR FT LLVAAVLFVPLADLSTLFAIVPSARVPGWGYILTALAAPVVTWAAWPFHSVALRNARHR FT TTSMETLISVGIVAATAWSLSSVFGDQPPREGSGIWRAILNSDSIYLEVAAGVTVFVLA FT GRYFEARAKSKAGSALRALAELGAKNVAVLLPDGAELVIPASELKKRQRFVTRPGETIA FT ADGVVVDGSAAIDMSAMTGEAKPVRAYPAASVVGGTVVMDGRLVIEATAVGADTQFAAM FT VRLVEQAQTQKARAQRLADHIAGVFVPVVFVIAGLAGAAWLVSGAGADRAFSVTLGVLV FT IACPCALGLATPTAMMVASGRGAQLGIFIKGYRALETIRSIDTVVFDKTGTLTVGQLAV FT STVTMAGSGTSERDREEVLGLAAAVESASEHAMAAAIVAASPDPGPVNGFVAVAGCGVS FT GEVGGHHVEVGKPSWITRTTPCHDAALVSARLDGESRGETVVFVSVDGVVRAALTIADT FT LKDSAAAAVAALRSRGLRTILLTGDNRAAADAVAAQVGIDSAVADMLPEGKVDVIQRLR FT EEGHTVAMVGDGINDGPALVGADLGLAIGRGTDVALGAADIILVRDDLNTVPQALDLAR FT ATMRTIRMNMIWAFGYNVAAIPIAAAGLLNPLIAGAAMAFSSFFVVSNSLRLRNFGAQ" FT CDS 122353..123867 FT /transl_table=11 FT /gene="Mb0107" FT /locus_tag="Mb0107" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0107, -, len: 504 aa. Equivalent to Rv0104, len: FT 504 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 504 aa overlap). Conserved hypothetical FT protein, showing weak similarity with other cAMP-dependent FT protein kinases e.g. AAC37564.1|M65066 cAMP-dependent FT protein kinase RI-beta regulatory subunit from Homo sapiens FT (380 aa); etc ." FT /db_xref="GOA:Q7U2U8" FT /db_xref="HSSP:1Q3E" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:Q7U2U8" FT /protein_id="CAD92969.1" FT /translation="MTPVTTFPLVDAILAGRDRNLDGVILIAAQHLLQTTHAMLRSLFR FT VGLDPRNVAVIGKCYSTHPGVVDAMRADGIYVDDCSDAYAPHESFDTQYTRHVEWFFAE FT SWARLTAGRTARVVLLDDGGSLLAVAGAMLDASADVIGIEQTSAGYAKIVGCALGFPVI FT NIARSSAKLLYESPIIAARVTQTAFERTAGIDSSAAILITGAGAIGTALADVLRPLHDR FT VDVYDTRSGCMTPIDLPNAIGGYDVIIGATGATSVPASMHELLRPGVLLMSASSSDREF FT DAVALRRRTTPNPDCHADLRVADGSVDATLLNSGFPVNFDGSPMCGDASMALTMALLAA FT AVLYASVAVADEMSSDHPHLGLIDQGDIVASFLNIDVPLQALSRLPLLSIDGYRRLQVR FT SGHTLFRQGERADHFFVIESGELEALVDGKVILRLGAGDHFGEACLLGGMRRIATVRAC FT EPSVLWELDGKAFGDALHGDAAMREIAYGVARTRLMHAGASESLMV" FT CDS complement(124016..124300) FT /transl_table=11 FT /gene="rpmB1" FT /locus_tag="Mb0108c" FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L28-1 RPMB1" FT /note="Mb0108c, rpmB1, len: 94 aa. Equivalent to Rv0105c, FT len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 94 aa overlap). Probable rpmB1, 50S FT ribosomal protein L28-1, highly similar to others e.g. FT Q9X8K8|R28B_STRCO 50S RIBOSOMAL PROTEIN L28-2 from FT Streptomyces coelicolor (78 aa); RL28_ECOLI|P02428 50s FT ribosomal protein l28 from Escherichia coli (77 aa), FASTA FT scores: opt: 167, E(): 6.2e-06, (40.7% identity in 59 aa FT overlap); etc. Also similar to MTCY63A_2 from Mycobacterium FT tuberculosis. BELONGS TO THE L28P FAMILY OF RIBOSOMAL FT PROTEINS." FT /db_xref="GOA:P0A5V7" FT /db_xref="InterPro:IPR001383" FT /db_xref="UniProtKB/Swiss-Prot:P0A5V7" FT /protein_id="CAD92970.1" FT /translation="MSARCQITGRTVGFGKAVSHSHRRTRRRWPPNIQLKAYYLPSEDR FT RIKVRVSAQGIKVIDRDGHRGRRRAARAGSAPAHFARQAGSSLRTAAIL" FT CDS 124410..125606 FT /transl_table=11 FT /gene="Mb0109" FT /locus_tag="Mb0109" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0109, -, len: 398 aa. Equivalent to Rv0106, len: FT 398 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 398 aa overlap). Conserved hypothetical FT protein, similar to others e.g. AL049841|SCE9_33 from FT Streptomyces coelicolor (370 aa), FASTA scores: opt: 282, FT E(): 2.5e-11, (32.0% identity in 381 aa overlap); etc. Some FT similarity to P94400 HOMOLOGUE TO NITRILE HYDRATASE REGION FT from Bacillus subtilis (397 aa), FASTA scores: opt: 226, FT E(): 5.4e-08, (26.4% identity in 405 aa overlap). Also FT similar to COBW_PSEDE|P29937 FASTA score: (25.3% identity FT in 186 aa overlap); and P47K_PSECL|P31521 47 kd protein FT (p47k) (419 aa), FASTA score: (25.9% identity in 401 aa FT overlap)." FT /db_xref="InterPro:IPR011629" FT /db_xref="UniProtKB/Swiss-Prot:P64692" FT /protein_id="CAD92971.1" FT /translation="MRTPVILVAGQDHTDEVTGALLRRTGTVVVEHRFDGHVVRRMTAT FT LSRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAPWLEPQPICW FT AIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSLGEDELPDGRTVAQVTVGQ FT AEFADLLVLTHPEPVAVAVLRRLAPRARITGGVDRVELALAHLDDNSRRGRTDTPHTPL FT LAGLPPLAADGEVAIVEFSARRPFHPQRLHAAVDLLLDGVVRTRGRLWLANRPDQVMWL FT ESAGGGLRVASAGKWLAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVLVCGADP FT TDIVNALNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAGEFSAHRNSGESR" FT CDS complement(125701..130578) FT /transl_table=11 FT /gene="ctpI" FT /locus_tag="Mb0111c" FT /product="PROBABLE CATION-TRANSPORTER ATPASE I CTPI" FT /EC_number="3.6.3.-" FT /note="Mb0111c, ctpI, len: 1625 aa. Equivalent to 5' end of FT Rv0107c, len: 1632 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.7% identity in 1572 aa overlap). Probable FT ctpI, cation-transporting ATPase I P-type (EC 3.6.3.-), FT highly similar to NP_302704.1|NC_002677 probable cation FT transport ATPase from Mycobacterium leprae (1609 aa); and FT similar to others e.g. CAB69720.1|AL137166 putative FT transport ATPase from Streptomyces coelicolor (1472 aa); FT ATA1_SYNY|P37367 cation-transporting ATPase pma1 from FT Synechocystis sp. (915 aa), FASTA scores: opt: 603, E(): FT 6.6e-29, (32.4% identity in 710 aa overlap); etc. Also FT similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium FT tuberculosis, FASTA score: (34.4% identity in 796 aa FT overlap). Contains PS00154 E1-E2 ATPases phosphorylation FT site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 FT ATPASES). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a single base insertion (*-t) leads to a product FT with a different COOH part compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv." FT /db_xref="GOA:Q7U2U7" FT /db_xref="InterPro:IPR008250" FT /db_xref="UniProtKB/TrEMBL:Q7U2U7" FT /protein_id="CAD92972.1" FT /translation="MKIPGVATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLEL FT TGPVVQSVVQTTGRAIGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPFPRWHEHAA FT MVEEPVRRIPGVAEAHVEGSLGRLVVELEPDVDSDIAVDEVRDVVSAVAADIFLAGSVS FT SPNSAPFADPGNPLAILVPLTAAAMDLVAMGATVTGWVARLPAAPQTTRALAALINHQP FT RMVSLMESRLGRVGTDIALAATTAAANGLTQSLGTPLLDLVQRSLQISEAAAHRRVWRD FT REPALASPRRPQAPVVPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAAIDTAKG FT SRAGPVEQYVNQAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAVLGR FT GLANTGQLVLDPGALRRLDRVRVVVIDGAALRGDNRAVLHAQGDEPGWDDDRVYEVADA FT LLHGEQAPEPDPDELPATGARLRWAPAQGPSATPAQGLEHADLVVDGQCVGSVDVGWEV FT DPYAIPLLQTAHRTGARVVLRHVAGTEDLSASVGSTHPPGTPLLKLVRELRADRGPVLL FT ITAVHRDFASTDTLAALAIADVGVALDDPRGATPWTADLITGTDLAAAVRILSALPVAR FT AASESAVHLAQGGTTLAGLLLVTGEQDKTTNPASFRRWLNPVNAAAATALVSGMWSAAK FT VLRMPDPTPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRILDDLSYEPVMAPL FT RGPARTLAQLAVATRHELADPLTPILAVGAAASAIVGSNIDALLVAGVMTVNAITGGVQ FT RLRAEAAAAELFAEQDQLVRRVVVPAVATTRRRLEAARHATRTATVSAKSLRVGDVIDL FT AAPEVVPADARLLVAEDLEVDESFLTGESLPVDKQVDPVAVNDPDRASMLFEGSTIVAG FT HARAIVVATGVGTAAHRAISAVADVETAAGVQARLRELTSKVLPMTLAGGAAVTALALL FT RRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTARGALVRSPRTIEALGRVD FT TICFDKTGTLTENRLRVVCALPSSTAAERDPLPQTTDAPSAEVLRAAARASTQPHNGEG FT HAHATDEAILAAASALAGSLSSQGDSEWVVLAEVPFESSRGYAAAIGRVGTDGIPMLML FT KGAPETILPRCRLADPGVDHEHAESVVRHLAEQGLRVLAVAQRTWDNGTTHDDETDADA FT VDAVAHDLELIGYVGLADTARPSSRPLIEALLDAERNVVLITGDHPITARAIARQLGLP FT ADARVVTGAELAVLDEEAHAKLAADMQVFARVSPEQKVQIVASLQRCGRVTAMVGDGAN FT DAAAIRMADVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTIL FT VGGNVGEVLFTVIGTAFGAGRAPVGTRQLLLVNLLTDMFPALAVAVTSQFAEPDDAEYP FT TDDAAERAQREHRRAVLIGPTPSLDAPLLRQIVNRGVVTAAGATAAWAIGRWTPGTERR FT TATMGLTALVMTQLAQTLLTRRHSPLVIATALGSAGVLVGIIQTPVISHFFGCTPLGPV FT AWTGVFSATAGATAVSALAPKWLASTVGVVQPDERPDDAEDSDAGG" FT CDS complement(130932..131141) FT /transl_table=11 FT /gene="Mb0112c" FT /locus_tag="Mb0112c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0112c, -, len: 69 aa. Equivalent to Rv0108c, len: FT 69 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 69 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2U6" FT /protein_id="CAD92973.1" FT /translation="MVPVETLHSGDPITDVNGGGQRYIVLESKTVGDSCVVLELESRVN FT HQLQVIEKSFPAGYHVGRAHHRIL" FT CDS 131420..132910 FT /transl_table=11 FT /gene="PE_PGRS1" FT /locus_tag="Mb0113" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb0113, PE_PGRS1, len: 496 aa. Equivalent to Rv0109, FT len: 496 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 496 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, highly similar to many e.g. FT Q50615|Y0DP_MYCTU HYPOTHETICAL GLYCINE-RICH 40.8 KD PROTEIN FT from Mycobacterium tuberculosis (498 aa), FASTA scores: FT opt: 1772, E(): 0, (57.3% identity in 513 aa overlap); FT etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U2U5" FT /protein_id="CAD92974.1" FT /translation="MSLLITSPATVAAAATHLAGIGSALSTANAAAAAPTTALSVAGAD FT EVSVLIAALFEAYAQEYQALSAQALAFHDQFVQALNMGAVCYAAAETANATPLQALQTV FT QQNVLTVVNAPTQALLGRPIIGNGANGLPNTGQDGGPGGLLFGNGGNGGSGGVDQAGGN FT GGAAGLIGNGGSGGVGGPGIAGSAGGAGGAGGLLFGNGGPGGAGGIGTTGDGGPGGAGG FT NAIGLFGSGGTGGMGGVGGMGGVGNGGNAGNGGTAGLFGHGGAGGAGGIGSADGGLGGG FT GGNGRFMGNGGVGGAGGYGASGDGGNAGNGGLGGVFGDGGAGGTGGLGDVNGGLAGIGG FT NAGFVGNGGAGGNGQLGSGAVSSAGGMGGNGGLVFGNGGPGGLGGPGTSAGNGGMGGNA FT VGLFGQGGAGGAGGSGFGAGIPGGRGGDGGSGGLIGDGGTGGGAGAGDAAASAGGNGGN FT ARLIGNGGDGGPGMFGGPGGAGGSGGTIFGFAGTPGPS" FT CDS 133058..133807 FT /transl_table=11 FT /gene="Mb0114" FT /locus_tag="Mb0114" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0114, -, len: 249 aa. Equivalent to Rv0110, len FT 249 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 249 aa overlap). Probable conserved FT integral membrane protein, similar to many e.g. FT AL079308|SCH69_25 from Streptomyces coelicolor (297 aa), FT FASTA scores: opt: 552, E(): 6.1e-29, (45.4% identity in FT 251 aa overlap); P54493|YQGP_BACSU HYPOTHETICAL 56.4 KD FT PROTEIN from Bacillus subtilis (507 aa), FASTA scores: opt: FT 320, E(): 4e-15, (32.4% identity in 210 aa overlap); etc." FT /db_xref="GOA:Q7U2U4" FT /db_xref="InterPro:IPR002610" FT /db_xref="UniProtKB/TrEMBL:Q7U2U4" FT /protein_id="CAD92975.1" FT /translation="MRVGPVGHQCAECVREGARAVRQPRTPFGGRQRSATPVVTYTLIS FT LNALVFVMQVTVMGLERQLALWPPAVASGQTYRLVTSAFLHYGAMHLLLNMWALYVVGP FT PLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNTATAGASGAVFGLFGATFMVARRLHL FT DVRWVVALIVINLAFTFLAPAISWQGHVGGLVTGALVAATYVYAPRERRNLIQATVTIT FT VLVAFVVLIGWRTVDLLALFGGRLNLS" FT CDS 133988..136045 FT /transl_table=11 FT /gene="Mb0115" FT /locus_tag="Mb0115" FT /product="POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE" FT /EC_number="2.3.1.-" FT /note="Mb0115, -, len: 685 aa. Equivalent to Rv0111, len: FT 685 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 685 aa overlap). Possible transmembrane FT acyltransferase (EC 2.3.1.-), equivalent to FT AA22904.1|AL035300 putative acyltransferase from FT Mycobacterium leprae (696 aa). Also similar to others e.g. FT C69975 acyltransferase homolog yrhL from Bacillus subtilis FT (634 aa), FASTA scores: opt: 520, E(): 4e-22, (36.4% FT identity in 382 aa overlap). Very similar to Mycobacterium FT tuberculosis proteins Rv0228, Rv1254, Rv1565c, etc." FT /db_xref="GOA:Q7U2U3" FT /db_xref="InterPro:IPR002656" FT /db_xref="UniProtKB/TrEMBL:Q7U2U3" FT /protein_id="CAD92976.1" FT /translation="MPARSVPRPRWVAPVRRVGRLAVWDRPERRSGIPALDGLRAIAVA FT LVLASHGGIPGMGGGFIGVDAFFVLSGFLITSLLLDELGRTGRIDLSGFWIRRARRLLP FT ALVLMVLTVSAARALFPDQALTGLRSDAIAAFLWTANWRFVAQNTDYFTQGAPPSPLQH FT TWSLGVEEQYYVVWPLLLIGATLLLAARARRRCRRATVGGVRFAAFLIASLGTMASATA FT AVAFTSAATRDRIYFGTDTRAQALLIGSAAAALLVRDWPSLNRGWCLIRTRWGRRIARL FT LPFVGLAGLAVTTHVATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAVARILAWRPL FT VWLGTISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAATVVLAGASWWLIEQPIRRW FT RPARVPLLPLAAATVASAAAVTMLVVPVGAGPGLREIGLPPGVSAVAAVSPSPPEASQP FT APGPRDPNRPFTVSVFGDSIGWTLMHYLPPTPGFRFIDHTVIGCSLVRGTPYRYIGQTL FT EQRAECDGWPARWSAQVNRDQPDVALLIVGRWETVDRVNEGRWTHIGDPTFDAYLNAEL FT QRALSIVGSTGVRVMVTTVPYSRGGEKPDGRLYPEDQPERVNKWNAMLHNAISQHSNVG FT MIDLNKKLCPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSVRVAS" FT CDS 136327..137283 FT /transl_table=11 FT /gene="gca" FT /locus_tag="Mb0116" FT /product="POSSIBLE GDP-MANNOSE 4,6-DEHYDRATASE GCA FT (GDP-D-MANNOSE DEHYDRATASE)" FT /EC_number="4.2.1.47" FT /note="Mb0116, gca, len: 318 aa. Equivalent to Rv0112, len: FT 318 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 318 aa overlap). Possible gca, FT GDP-mannose 4,6-dehydratase (EC 4.2.1.47), similar to FT others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas FT aeruginosa (323 aa), FASTA scores: opt: 415, E(): 4.4e-21, FT (27.0% identity in 318 aa overlap). Similar to Rv3634c, FT Rv3784, etc from Mycobacterium tuberculosis. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature. SEEMS TO BELONG TO THE GDP-MANNOSE FT 4,6-DEHYDRATASE FAMILY. COFACTOR: NAD(+)." FT /db_xref="GOA:Q7U2U2" FT /db_xref="HSSP:1DB3" FT /db_xref="InterPro:IPR001509" FT /db_xref="UniProtKB/TrEMBL:Q7U2U2" FT /protein_id="CAD92977.1" FT /translation="MKVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPTIDPSDLQFNG FT AEVDITDWCSVYDSIATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEALRR FT VRPHAKIIVAGSSAEYGFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSYGMH FT TVVARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVRDLNRAL FT MLMLDKGEAGADYNVGGSIAYEMGDVLKQVIAACKRDDIVPEVDPALLRPTDEKIIYGD FT CSKLAAITGWQQEICLTQTIADMFDYWRSKSESALMV" FT CDS 137357..137947 FT /transl_table=11 FT /gene="gmhA" FT /locus_tag="Mb0117" FT /product="PROBABLE PHOSPHOHEPTOSE ISOMERASE GMHA" FT /EC_number="5.-.-.-" FT /note="Mb0117, gmhA, len: 196 aa. Equivalent to Rv0113, FT len: 196 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 196 aa overlap). Probable gmhA FT (alternate gene name: lpcA), phosphoheptose isomerase (EC FT 5.-.-.-), similar to many e.g. AE0005|HPAE000596_11 from FT Helicobacter pylori (192 aa), FASTA scores: opt: 451, E(): FT 1.9e-24, (45.1% identity in 162 aa overlap). BELONGS TO THE FT SIS FAMILY, LPCA SUBFAMILY." FT /db_xref="GOA:P0A605" FT /db_xref="InterPro:IPR001347" FT /db_xref="UniProtKB/Swiss-Prot:P0A605" FT /protein_id="CAD92978.1" FT /translation="MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAG FT ARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTVFA FT RALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADFLIN FT VPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ" FT CDS 137979..138551 FT /transl_table=11 FT /gene="Mb0118" FT /locus_tag="Mb0118" FT /product="POSSIBLE DEHYDRATASE" FT /EC_number="4.-.-.-" FT /note="Mb0118, -, len: 190 aa. Equivalent to Rv0114, len: FT 190 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 190 aa overlap). Possible dehydratase FT (EC 4.-.-.-), similar to several hypothetical proteins and FT to HIS7_ECOLI|P06987 imidazoleglycerol-phosphate FT dehydratase (355 aa), FASTA scores: opt: 250, E(): 3.6e-11, FT (34.0 % identity in 141 aa overlap)." FT /db_xref="GOA:Q7U2U1" FT /db_xref="InterPro:IPR006543" FT /db_xref="UniProtKB/Swiss-Prot:Q7U2U1" FT /protein_id="CAD92979.1" FT /translation="MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARAL FT KKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHRSQ FT RCGCRKPRPGLVLDWLRRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIGGAS FT SGGVADASFDSLWEFAVAVGHARGERG" FT CDS 138702..139619 FT /transl_table=11 FT /gene="Mb0119" FT /locus_tag="Mb0119" FT /product="POSSIBLE SUGAR KINASE" FT /EC_number="2.-.-.-" FT /note="Mb0119, -, len: 305 aa. Equivalent to Rv0115, len: FT 386 aa, from Mycobacterium tuberculosis strain H37Rv, FT (98.5% identity in 275 aa overlap). Possible sugar kinase FT (EC 2.-.-.-), similar to several hypothetical proteins and FT sugar kinases e.g. AAK27850.1|AF324836_3 FT D-glycero-D-manno-heptose 7-phosphate kinase from FT Aneurinibacillus thermoaerophilus (341 aa); FT AAK80995.1|AE007802_11 Sugar kinase from Clostridium FT acetobutylicum (364 aa). REMARK-M.bovis-M.tuberculosis: In FT Mycobacterium bovis, a single base insertion (*-c) leads to FT shorter product with a different COOH part compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv." FT /db_xref="GOA:Q7U2U0" FT /db_xref="InterPro:IPR013750" FT /db_xref="UniProtKB/TrEMBL:Q7U2U0" FT /protein_id="CAD92980.1" FT /translation="MRSPFARRTATEPARPRSTIWRLSKKTLPLHVAVYRRVIAEFNGG FT TPFPLQLATQVDAPPGSGLGSSSALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLG FT MAGGWQDHYAAAFGGFNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSE FT VIADQQRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRTSTR FT ISNPAIEHAYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPC FT LFTKGGAVTWHIPESTAPRKAWSC" FT CDS complement(140307..141062) FT /transl_table=11 FT /gene="Mb0120c" FT /locus_tag="Mb0120c" FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0120c, -, len: 251 aa. Equivalent to Rv0116c, len: FT 251 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 251 aa overlap). Possible conserved FT membrane protein, showing similarity to several FT hypothetical mycobacterial proteins e.g. Rv1433 from FT Mycobacterium tuberculosis (271 aa); and FT Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 FT aa); to the C-terminal regions of others like Rv0192 from FT Mycobacterium tuberculosis (366 aa), FASTA scores: opt: FT 451, E(): 1.7e-21, (46.7% identity in 270 aa overlap); and FT Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis FT cosmid (366 aa), FASTA scores: opt: 699, E(): 0, (45.7% FT identity in 221 aa overlap). TBparse score is 0.932." FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:Q7U2T9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92981.1" FT /translation="MRRVVRYLSVVVAITLMLTAESVSIATAAVPPLQPIPGVASVSPA FT NGAVVGVAHPVVVTFTTPVTDRRAVERSIRISTPHNTTGHFEWVASNVVRWVPHRYWPP FT HTRVSVGVQELTEGFETGDALIGVASISAHTFTVSRNGEVLRTMPASLGKPSRPTPIGS FT FHAMSKERTVVMDSRTIGIPLNSSDGYLLTAHYAVRVTWSGVYVHSAPWSVNSQGYANV FT SHGCINLSPDNAAWYFDAVTVGDPIEVVG" FT CDS 141240..142184 FT /transl_table=11 FT /gene="oxyS" FT /locus_tag="Mb0121" FT /product="OXIDATIVE STRESS RESPONSE REGULATORY PROTEIN FT OXYS" FT /note="Mb0121, oxyS, len: 314 aa. Equivalent to Rv0117, FT len: 314 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 314 aa overlap). OxyS, oxidative stress FT response protein regulatory protein, LysR family (see FT citation below). Similar to many transcription regulators FT and OxyR, the oxidative stress response protein of many FT bacteria. Contains LysR family signature at N-terminus. FT Also contains helix-turn-helix motif at aa 16-37 (Score FT 1543, +4.44 SD). BELONGS TO THE LYSR FAMILY OF FT TRANSCRIPTIONAL REGULATORS. OXYR IS REQUIRED FOR THE FT INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE GENES FT SUCH AS CATALASE, GLUTATHIONE-REDUCTASE, ETC." FT /db_xref="GOA:Q7U2T8" FT /db_xref="HSSP:1IXC" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q7U2T8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92982.1" FT /translation="MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNV FT TLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTT FT ASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQDSDDVDLVPLYE FT EQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQVIDAAFADHAVSAIPQVET FT DSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALG FT PGSPVARALITCAQALALNEFFDTQLRGITRRR" FT CDS complement(142168..143916) FT /transl_table=11 FT /gene="oxcA" FT /locus_tag="Mb0122c" FT /product="PROBABLE OXALYL-COA DECARBOXYLASE OXCA" FT /EC_number="4.1.1.8" FT /note="Mb0122c, oxcA, len: 582 aa. Equivalent to Rv0118c, FT len: 582 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 582 aa overlap). Probable oxcA, FT oxalyl-CoA decarboxylase (EC 4.1.1.8), highly similar to FT many e.g. FT P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325 FT PROBABLE OXALYL-CoA DECARBOXYLASE from Escherichia coli FT (564 aa); M77128|OXAOXA_1 oxalyl-CoA decarboxylase from FT Oxalobacter formigenes (568 aa), FASTA scores: opt: 2124, FT E():0, (55.6% identity in 568 aa overlap). Also similar to FT mycobacterial IlvB proteins e.g. MLCB1788.46c unknown FT TPP-requiring enzyme from Mycobacterium leprae (548 aa); FT and AL0086|MLCB1788_19 from Mycobacterium leprae (548 aa), FT FASTA scores: opt: 831, E(): 0, (33.9% identity in 567 aa FT overlap)." FT /db_xref="GOA:Q7U2T7" FT /db_xref="HSSP:1OZH" FT /db_xref="InterPro:IPR012001" FT /db_xref="UniProtKB/TrEMBL:Q7U2T7" FT /protein_id="CAD92983.1" FT /translation="MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARA FT AQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCFPM FT IQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTATSGR FT PGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLV FT LGKGAAYAQADNVIREFVEHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLL FT VGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSALLEAAA FT DRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVN FT EGANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGF FT SGMEFETICRYRLPVTVVILNNGGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELI FT AEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGVESGHLAKLNTTSAATP FT AISGDG" FT CDS 144089..145666 FT /transl_table=11 FT /gene="fadD7" FT /locus_tag="Mb0123" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD7 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb0123, fadD7, len: 525 aa. Equivalent to Rv0119, FT len: 525 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 525 aa overlap). Probable fadD7, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to FT 4-coumarate:CoA ligase of many organisms e.g. FT U39405|PTU39405_1 4-coumarate:CoA ligase from Pinus FT taedaxylem (537 aa), FASTA scores: opt: 483, E(): 8.3e-22, FT (28.2% identity in 440 aa overlap). Contains PS00455 FT Putative AMP-binding domain signature. TBscore is 0.896." FT /db_xref="GOA:Q7U2T6" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U2T6" FT /protein_id="CAD92984.1" FT /translation="MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVD FT ELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQA FT AGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPE FT GLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLYHGHG FT LIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEPS FT GRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTET FT PVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDG FT WLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQ FT LYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAV FT AERFGHSV" FT CDS complement(145667..147460) FT /transl_table=11 FT /gene="fusA2b" FT /locus_tag="Mb0124c" FT /standard_name="fus2" FT /product="PROBABLE ELONGATION FACTOR G FUSA2B [SECOND PART] FT (EF-G)" FT /note="Mb0124c, fusA2b, len: 597 aa. Equivalent to 3' end FT of Rv0120c, len: 714 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.8% identity in 597 aa overlap). Probable FT fusA2 (alternate gene name: fus2), elongation factor G, FT highly similar to others e.g. EFG_ECOLI|P02996 elongation FT factor G (ef-g) from Escherichia coli (703 aa), FASTA FT scores: opt: 1049, E(): 0, (32.5% identity in 717 aa FT overlap). Also similar to fusA1|MTCY210.01 from FT Mycobacterium tuberculosis FASTA score: (39.1% identity in FT 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G FT (EF-G) from Mycobacterium leprae (701 aa), FASTA score: FT (31.7% identity in 710 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, fusA2 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a 2bp to 1bp FT substitution (gc-t), splits fusA2 into 2 parts, fusA2a and FT fusA2b." FT /db_xref="GOA:Q7U2T5" FT /db_xref="HSSP:1ELO" FT /db_xref="InterPro:IPR005517" FT /db_xref="UniProtKB/TrEMBL:Q7U2T5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92985.1" FT /translation="MIAANEGVDEPTKSLWQECSQVGMPRAVVITKLDHARANYREALT FT AAQDAFGDKVLPLYLPSGDGLIGLLSQALYEYADGKRTTRTPAESDTERIEEARGALIE FT GIIEESEDESLMERYLGGETIDESVLIQDLEKAVARGSFFPVIPVCSSTGVGTLELLEV FT ATRGFPSPMEHPLPEVFTPQGVPHAELACDNDAPLLAEVVKTTSDPYVGRVSLVRVFSG FT TIRPDTTVHVSGHFSSFFGGGTSNTHPDHDEDERIGVLSFPLGKQQRPAAAVVAGDICA FT IGKLSRAETGDTLSDKAEPLVLKPWTMPEPLLPIAIAAHAKTDEDKLSVGLGRLAAEDP FT TLRIEQNQETHQVVLWCMGEAHAGVVLDTLANRYGVSVDTIELRVPLRETFAGNAKGHG FT RHIKQSGGHGQYGVCDIEVEPLPEGSGFEFLDKVVGGAVPRQFIPSVEKGVRAQMDKGV FT HAGYPVVDIRVTLLDGKAHSVDSSDFAFQMAGALALREAAAATKVILLEPIDEISVLVP FT DDFVGAVLGDLSSRRGRVLGTETAGHDRTVIKAEVPQVELTRYAIDLRSLAHGAASFTR FT SFARYEPMPESAAARVKAGAG" FT CDS complement(147457..147810) FT /transl_table=11 FT /gene="fusA2a" FT /locus_tag="Mb0125c" FT /standard_name="fus2" FT /product="PROBABLE ELONGATION FACTOR G FUSA2A [FIRST PART] FT (EF-G)" FT /note="Mb0125c, fusA2a, len: 117 aa. Equivalent to 5' end FT of Rv0120c, len: 714 aa, from Mycobacterium tuberculosis FT strain H37Rv, (98.1% identity in 108 aa overlap). Probable FT fusA2 (alternate gene name: fus2), elongation factor G, FT highly similar to others e.g. EFG_ECOLI|P02996 elongation FT factor G (ef-g) from Escherichia coli (703 aa), FASTA FT scores: opt: 1049, E(): 0, (32.5% identity in 717 aa FT overlap). Also similar to fusA1|MTCY210.01 from FT Mycobacterium tuberculosis FASTA score: (39.1% identity in FT 299 aa overlap); and P30767|EFG_MYCLE ELONGATION FACTOR G FT (EF-G) from Mycobacterium leprae (701 aa), FASTA score: FT (31.7% identity in 710 aa overlap). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FT GTP-BINDING ELONGATION FACTOR FAMILY, EF-G/EF-2 SUBFAMILY. FT REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, fusA2 exists as a single gene. FT In Mycobacterium bovis, a frameshift due to the FT substitution of a single base (gc-t), splits fusA2 into 2 FT parts, fusA2a and fusA2b." FT /db_xref="GOA:Q7U2T4" FT /db_xref="InterPro:IPR000795" FT /db_xref="UniProtKB/TrEMBL:Q7U2T4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92986.1" FT /translation="MADRVNASQGAAAAPTANGPGGVRNVVLVGPSGGGKTTLIEALLV FT AAKVLSRPGSVTEGTTVCDFDEAEIRQQRSVGLAVASLAYDGIKVNLVDTPGYADFVGE FT LWPGCGPPIAHCS" FT CDS complement(147946..148380) FT /transl_table=11 FT /gene="Mb0126c" FT /locus_tag="Mb0126c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0126c, -, len: 144 aa. Equivalent to Rv0121c, len: FT 144 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 144 aa overlap). Conserved hypothetical FT protein, showing some similarity with others proteins from FT Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074, FT etc." FT /db_xref="GOA:Q7U2T3" FT /db_xref="InterPro:IPR011576" FT /db_xref="UniProtKB/TrEMBL:Q7U2T3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92987.1" FT /translation="MGEFDPKLRFAQSPVARLATSTPDGTPHLVPVVFALGARRPAEAT FT GADVIYTAVDAKRKTTQRLRRLANLEHNPRASVLVDSYADDWTQLWWVRADGVAAIHRD FT GEVMRAAYRLLRAKYAQYQSVPLNGPVIAIAVQRWASWHA" FT CDS 148529..148897 FT /transl_table=11 FT /gene="Mb0127" FT /locus_tag="Mb0127" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0127, -, len: 122 aa. Equivalent to Rv0122, len: FT 122 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 122 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2T2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92988.1" FT /translation="MAGSVSAAAGIGWVGLNVTETNRDQCYRVERTTVDALTHPEYRVH FT TRGVQRVRVTRNARKHRVSKHRIVAAMRHCGVPVIQEDGSLYYQGRDTSGRLTEVVAVE FT ADDGDLIITHAMPKEWKR" FT CDS 148894..149262 FT /transl_table=11 FT /gene="Mb0128" FT /locus_tag="Mb0128" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0128, -, len: 122 aa. Equivalent to Rv0123, len: FT 122 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 122 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2T1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92989.1" FT /translation="MTKKPRNPADYVIGDDVEVSDVDLKQEEVYVDGERLTDERVEQMA FT SESLRLAREREANLIPGGKSLSGGSAHSPAVQVVVSKATHAKLKELARSRKMSVSKLLR FT PVLDEFVQRETGRILPRR" FT CDS 149571..151187 FT /transl_table=11 FT /gene="PE_PGRS2" FT /locus_tag="Mb0129" FT /product="PE-PGRS FAMILY PROTEIN" FT /note="Mb0129, PE_PGRS2, len: 538 aa. Similar to Rv0124, FT len: 487 aa, from Mycobacterium tuberculosis strain H37Rv, FT (87.4% identity in 547 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, PGRS subfamily of FT gly-rich proteins, highly similar to many e.g. FT Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FT FASTA scores: opt: 1730, E(): 0, (60.7% identity in 504 aa FT overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a 180 bp insertion leads to a longer product in the FT 3' direction compared to its homolog in Mycobacterium FT tuberculosis strain H37Rv (538 aa versus 487 aa)." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U2T0" FT /protein_id="CAD92990.1" FT /translation="MSFVSVAPEIVVAAATDLAGIGSAISAANAAAAAPTTAVLAAGAD FT EVSAAIAALFSGHAQAYQALSAQAAAFHQQFVQTLAGGAGAYAAAEAQVEQQLLAAINA FT PTQALLGRPLIGNGADGAPGTGQAGGAGGILYGNGGNGGSGAAGQAGGAGGPAGLIGHG FT GSGGAGGHGGWLWGNGGVGGSGGAGVGAGVAGGHGGAGGAAGLWGAGGGGGNGGNGADA FT NIVSGGDGGLGGAGGGGGWLYGDGGAGGHGGQGAIGLGGGAGGDGGQGGAGRGLWGTGG FT AGGHGGQGGGTGGPPLPGQAGMGAAGGAGGLIGNGGAGGDGGVGASGGVAGVGGAGGNA FT MLIGHGGAGGAGGDSSFANGAAGGAGGAGGHLFGNGGSGGHGGAVTAGNTGIGGAGGVG FT GDARLIGHGGAGGAGGDRAGALVGRDGGPGGNGGAGGQLYGNGGDGGPGGQGGQAFGAN FT NIGGTGGAGGNGGPAILSGNGGNGGAGGAGGAGGAGGGAGGVGGAGGAPGTGGTLQAAV FT SGLVTALFGAPGQPGDTGQPG" FT CDS 151339..152406 FT /transl_table=11 FT /gene="pepA" FT /locus_tag="Mb0130" FT /product="PROBABLE SERINE PROTEASE PEPA" FT /EC_number="3.4.21.-" FT /note="Mb0130, pepA, len: 355 aa. Equivalent to Rv0125, FT len: 355 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 355 aa overlap). Probable pepA, serine FT protease (EC 3.4.21.-), highly similar to other proteases FT e.g. HHOB_ECOLI|P31137 protease hhob precursor (355 aa), FT FASTA scores: opt: 400, E(): 3.8e-14, (32.4% identity in FT 346 aa overlap). Also similar to Q50320 34 KDA protein FT precursor from Mycobacterium tuberculosis (361 aa), FASTA FT scores: opt: 1689, E(): 0, (70.7% identity in 362 aa FT overlap). Contains PS00135 Serine proteases, trypsin FT family, serine active site. Has a possible signal sequence FT at the N-terminus." FT /db_xref="GOA:Q7U2S9" FT /db_xref="InterPro:IPR018114" FT /db_xref="UniProtKB/TrEMBL:Q7U2S9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92991.1" FT /translation="MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFADF FT PALPLDPSAMVAQVGPQVVNINTKLGYNNAVGAGTGIVIDPNGVVLTNNHVIAGATDIN FT AFSVGSGQTYGVDVVGYDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSGGQG FT GTPRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQVVGM FT NTAASDNFQLSQGGQGFAIPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNGNG FT ARVQRVVGSAPAASLGISTGDVITAVDGAPINSATAMADALNGHHPGDVISVTWQTKSG FT GTRTGNVTLAEGPPA" FT CDS 152515..154320 FT /transl_table=11 FT /gene="treS" FT /locus_tag="Mb0131" FT /product="TREHALOSE SYNTHASE TRES" FT /EC_number="5.4.99.-" FT /note="Mb0131, treS, len: 601 aa. Equivalent to Rv0126, FT len: 601 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 601 aa overlap). treS, trehalose FT synthase (EC 5.4.99.-) (see citation below), highly similar FT to others e.g. CAA04601.2|AJ001205 putative trehalose FT synthase from Streptomyces coelicolor (566 aa); FT S71450|1536814|BAA11303.1|D78198 trehalose synthase FT maltose-specific from Pimelobacter sp. strain R48 (573 aa). FT Also similar to MAL1_DROME|P07191 possible maltase FT precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7% FT identity in 504 aa overlap); and similar to proteins FT associated with amino-acid transport e.g. Q64319 rat FT protein which stimulates transport of cystine and dibasic FT and neutral amino acids (683 aa), FASTA scores: opt: 839, FT E(): 0, (32.0% identity in 531 aa overlap). Also similar to FT several other Mycobacterium tuberculosis proteins e.g. FT Rv2471 FASTA score: (31.7% identity in 164 aa overlap)." FT /db_xref="GOA:Q7U2S8" FT /db_xref="HSSP:1M53" FT /db_xref="InterPro:IPR013781" FT /db_xref="UniProtKB/TrEMBL:Q7U2S8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92992.1" FT /translation="MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWFK FT HAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYDSPLRDGGYDIR FT DFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHPWFQESRRDPDGPYGDY FT YVWSDTSERYTDARIIFVDTEESNWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMID FT VIRFWLGLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEA FT NQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIAQTPPIPDMA FT QWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDNDRNQIELF FT TALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPP FT SQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLAYV FT RQVAGDDGDTVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIGQVPYLLTLPG FT HGFYWFQLTTHEVGAPPTCGGERRL" FT CDS 154423..155790 FT /transl_table=11 FT /gene="Mb0132" FT /locus_tag="Mb0132" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0132, -, len: 455 aa. Equivalent to Rv0127, len: FT 455 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 455 aa overlap). Conserved hypothetical FT protein, highly similar to various proteins e.g. FT AJ0012|SCJ001205_4 hypothetical protein from Streptomyces FT coelicolor A3(2) (464 aa), FASTA scores: opt: 412, E(): FT 1.1e-19, (40.6% identity in 485 aa overlap); FT AJ0012|SCJ001206_5 hypothetical protein from Streptomyces FT coelicolor A3(2) (453 aa), FASTA scores: opt: 403, E(): 4.3 FT e-19, (36.5% identity in 455 aa overlap)." FT /db_xref="InterPro:IPR002575" FT /db_xref="UniProtKB/TrEMBL:Q7U2S7" FT /protein_id="CAD92993.1" FT /translation="MTRSDTLATKLPWSDWLPRQRWYAGRNRELATVKPGVVVALRHNL FT DLVLVDVTYTDGATERYQVLVGWDFEPASEYGTKAAIGVADDRTGFDALYDVAGPQFLL FT SLIVSSAVCGTSTGEVTFTREPDVELPFAAQPRVCDAEQSNTSVIFDRRAILKVFRRVS FT SGINPDIELNRVLTRAGNPHVARLLGAYQFGRPNRSPTDALAYALGMVTEYEANAAEGW FT AMATASVRDLFAEGDLYAHEVGGDFAGESYRLGEAVASVHATLADSLGTAQATFPVDRM FT LARLSSTVAVVPELREYAPTIEQQFQKLAAEAITVQRVHGDLHLGQVLRTPESWLLIDF FT EGEPGQPLDERRAPDSPLRDVAGVLRSFEYAAYGPLVDQATDKQLAARAREWVERNRAA FT FCDGYAVASGIDPRDSALLLGAYELDKAVYETGYETRHRPGWLPIPLRSIARLTAS" FT CDS 155858..156637 FT /transl_table=11 FT /gene="Mb0133" FT /locus_tag="Mb0133" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0133, -, len: 259 aa. Equivalent to Rv0128, len: FT 259 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 259 aa overlap). Probable conserved FT transmembrane protein, with some similarity to Rv3064c and FT other bacterial proteins e.g. FT AAK85977.1|AE007957|AGR_C_254p from Agrobacterium FT tumefaciens (206 aa)." FT /db_xref="GOA:Q7U2S6" FT /db_xref="InterPro:IPR010699" FT /db_xref="UniProtKB/TrEMBL:Q7U2S6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92994.1" FT /translation="MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQR FT AVLGLFGDDAWMSVTASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAAGV FT DIMLGGWHESMLDFVPILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIERHL FT AGGKVEDWLGYFLLHASFVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLHADRR FT GLVNQKRPQPGKRLFRALRRGELDSGTSTPATNYGSS" FT CDS complement(156769..157791) FT /transl_table=11 FT /gene="fbpC" FT /locus_tag="Mb0134c" FT /standard_name="mpt45; 85C; fbpC2" FT /product="SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 FT COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) FT (FIBRONECTIN-BINDING PROTEIN C)" FT /EC_number="2.3.1.-" FT /note="Mb0134c, fbpC, len: 340 aa. Equivalent to Rv0129c, FT len: 340 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 340 aa overlap). fbpC (alternate gene FT names: mpt45, 85C, fbpC2), secreted antigen 85c FT (fibronectin-binding protein C) (mycolyl transferase 85C) FT (EC 2.3.1.-) (see citations below), also highly similar to FT other Mycobacterial antigen precursors e.g. FT A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from FT Mycobacterium leprae (333 aa), FASTA scores: opt: 1937, FT E(): 0, (81.4% identity in 333 aa overlap); etc." FT /db_xref="GOA:P0A4V5" FT /db_xref="InterPro:IPR000801" FT /db_xref="UniProtKB/Swiss-Prot:P0A4V5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92995.1" FT /translation="MTFFEQVRRLRSAATTLPRRLAIAAMGAVLVYGLVGTFGGPATAG FT AFSRPGLPVEYLQVPSASMGRDIKVQFQGGGPHAVYLLDGLRAQDDYNGWDINTPAFEE FT YYQSGLSVIMPVGGQSSFYTDWYQPSQSNGQNYTYKWETFLTREMPAWLQANKGVSPTG FT NAAVGLSMSGGSALILAAYYPQQFPYAASLSGFLNPSEGWWPTLIGLAMNDSGGYNANS FT MWGPSSDPAWKRNDPMVQIPRLVANNTRIWVYCGNGTPSDLGGDNIPAKFLEGLTLRTN FT QTFRDTYAADGGRNGVFNFPPNGTHSWPYWNEQLVAMKADIQHVLNGATPPAAPAAPAA FT " FT CDS 158038..158493 FT /transl_table=11 FT /gene="Mb0135" FT /locus_tag="Mb0135" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0135, -, len: 151 aa. Equivalent to Rv0130, len: FT 151 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 151 aa overlap). Conserved hypothetical FT protein, most similar to AL096811|SCI30A_19 from FT Streptomyces coelicolor (153 aa), FASTA scores: opt: 639, FT E(): 0, (60.8% identity in 148 aa overlap). Also similar to FT NODN_RHILV|P08634 nodulation protein from Rhizobium FT leguminosarum bv. viciae plasmid pRL1JI (161 aa), FASTA FT scores: opt: 406, E(): 1e-21, (43.9% identity in 148 aa FT overlap; and to O30041 MONOAMINE OXIDASE REGULATORY PROTEIN FT (146 aa), FASTA scores: opt: 219, E(): 1.1e-08, (30.8% FT identity in 133 aa overlap)." FT /db_xref="GOA:Q7U2S5" FT /db_xref="HSSP:1IQ6" FT /db_xref="InterPro:IPR002539" FT /db_xref="UniProtKB/Swiss-Prot:Q7U2S5" FT /protein_id="CAD92996.1" FT /translation="MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWIH FT VDPERAAAGPFGTTIAHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPVGS FT RVRATSSLVGVEDLGNGTVQATVSTTVEVEGSAKPACVAESIVRYVA" FT CDS complement(158506..159849) FT /transl_table=11 FT /gene="fadE1" FT /locus_tag="Mb0136c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE1" FT /EC_number="1.3.99.-" FT /note="Mb0136c, fadE1, len: 447 aa. Equivalent to Rv0131c, FT len: 447 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 447 aa overlap). Probable fadE1, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain FT specific precursor (412 aa), FASTA scores: opt: 522, E(): FT 1.4e-23, (30.1% identity in 425 aa overlap). Also highly FT similar to MTCI5_28 from Mycobacterium tuberculosis." FT /db_xref="GOA:Q7U2S4" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7U2S4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD92997.1" FT /translation="MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVA FT LDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSRWA FT PSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLFVTA FT ATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEI FT VRNVGVGAESTRHASHGYIRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIA FT LARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHD FT YQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATE FT LHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF" FT CDS complement(159891..160973) FT /transl_table=11 FT /gene="fgd2" FT /locus_tag="Mb0137c" FT /product="PUTATIVE F420-DEPENDANT GLUCOSE-6-PHOSPHATE FT DEHYDROGENASE FGD2" FT /EC_number="1.-.-.-" FT /note="Mb0137c, fgd2, len: 360 aa. Equivalent to Rv0132c, FT len: 360 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 360 aa overlap). Putative fgd2, FT F420-dependent glucose-6-phosphate dehydrogenase (EC FT 1.-.-.-), highly similar to many from Mycobacteria e.g. FT AAD38167|g5031431 from Mycobacterium chelonae. Also similar FT to MJ1534|Q58929 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN FT REDUCTASE from METHANOCOCCUS JANNASCHII (342 aa), FASTA FT scores: opt: 285, E(): 7.9e-11, (28.4% identity in 292 aa FT overlap). And also similar to Rv0953c, Rv0791c, etc from FT Mycobacterium tuberculosis. Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q7U2S3" FT /db_xref="InterPro:IPR019945" FT /db_xref="UniProtKB/TrEMBL:Q7U2S3" FT /protein_id="CAD92998.1" FT /translation="MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVG FT VVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNSTS FT SILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGKRLNEQAATDTFGNYRE FT RHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAG FT RYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLW FT RFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFP FT QDDPITAIDFYRTNVLPELR" FT CDS 161060..161665 FT /transl_table=11 FT /gene="Mb0138" FT /locus_tag="Mb0138" FT /product="PUTATIVE ACETYLTRANSFERASE" FT /EC_number="2.3.1.-" FT /note="Mb0138, -, len: 201 aa. Equivalent to Rv0133, len: FT 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 201 aa overlap). Putative FT acetyltransferase (EC 2.3.1.-), highly similar to others FT e.g. PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199 FT aa), FASTA scores: opt: 341, E(): 1.8e-16, (33.3% identity FT in 201 aa overlap)." FT /db_xref="GOA:Q7U2S2" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q7U2S2" FT /protein_id="CAD92999.1" FT /translation="MTPQARPARRADVRELSRTMARAFYDDPFMSWLLSNDNARTARLT FT RLFATIVRHQHLAGGGVEVARGAAGIGGAALWDPPDRWRESRRQQLAMTPGFLRVFGFR FT TAKARAALDVMMRVHPEEPHWYLAAIGSDPTVRGQGFGQVLMRSRLDRCDAEHCPAYLE FT STKPENVPYYQRFGFRVTREIALPDAGPPLWAMWREPR" FT CDS 161962..162345 FT /pseudo FT /transl_table=11 FT /gene="Mb0139-1" FT /locus_tag="Mb0139-1" FT /note="Mb0139-1, -, len: 128 aa. Pseudogene part1 of FT Rv0134/ephF" FT CDS 162345..162452 FT /pseudo FT /transl_table=11 FT /gene="Mb0139-2" FT /locus_tag="Mb0139-2" FT /note="Mb0139-2, -, len: 36 aa. Pseudogene part2 of FT Rv0134/ephF" FT CDS 162454..162693 FT /pseudo FT /transl_table=11 FT /gene="Mb0139-3" FT /locus_tag="Mb0139-3" FT /note="Mb0139-3, -, len: 80 aa. Pseudogene part3 of FT Rv0134/ephF" FT CDS 162696..162863 FT /pseudo FT /transl_table=11 FT /gene="Mb0139-4" FT /locus_tag="Mb0139-4" FT /note="Mb0139-4, -, len: 55 aa. Pseudogene part4 of FT Rv0134/ephF." FT CDS complement(162834..163439) FT /transl_table=11 FT /gene="Mb0140c" FT /locus_tag="Mb0140c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0140c, -, len: 201 aa. Equivalent to Rv0135c, len: FT 201 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 201 aa overlap). Possible FT transcriptional regulator, weakly similar to others e.g. FT P32398|YHGD_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR FT from Bacillus subtilis (191 aa), FASTA scores: opt: 145, FT E(): 0.0012, (21.0% identity in 162 aa overlap)." FT /db_xref="GOA:Q7U2S1" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q7U2S1" FT /protein_id="CAD93004.1" FT /translation="MTAVAAGALVVETDSFRLRLLDGLVASIGERGYRATTVSDIVRHA FT RTSKRTFYDRFTSKEQCFLELLLADNETLGNSIRAAVDPNADWHDQIRQAVEAYVTHIE FT SRPAVTLSWIREFPSLGAAAYPVQRRGMEQLTSLLIELSASPGFRRANLPPLNVPLAVI FT LLGGLRELTALTVEDGQPIRNIVEPAVDASIALLGPRS" FT CDS 163556..164881 FT /transl_table=11 FT /gene="cyp138" FT /locus_tag="Mb0141" FT /product="PROBABLE CYTOCHROME P450 138 CYP138" FT /EC_number="1.14.-.-" FT /note="Mb0141, cyp138, len: 441 aa. Equivalent to Rv0136, FT len: 441 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 441 aa overlap). Probable cyp138, FT cytochrome P450 138 (EC 1.14.-.-), similar to others e.g. FT SLR0574|Q59990 from SYNECHOCYSTIS SP. (444 aa), FASTA FT scores: opt: 315, E(): 1e-13, (25.7% identity in 416 aa FT overlap); etc. Also similar to MTV039_6 from Mycobacterium FT tuberculosis (472 aa), FASTA score: (38.2% identity in 442 FT aa overlap). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop); and PS00086 Cytochrome P450 cysteine heme-iron FT ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY." FT /db_xref="GOA:P63718" FT /db_xref="InterPro:IPR002401" FT /db_xref="UniProtKB/Swiss-Prot:P63718" FT /protein_id="CAD93005.1" FT /translation="MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVRR FT YGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGDDH FT RRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILRAIF FT GAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVIDKLIE FT AERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLGWAFER FT LSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGEWVIPRG FT YSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAAFANMEMD FT VVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR" FT CDS complement(164902..165450) FT /transl_table=11 FT /gene="msrA" FT /locus_tag="Mb0142c" FT /product="PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE FT MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE MET(O) FT REDUCTASE)" FT /EC_number="1.8.4.6" FT /note="Mb0142c, msrA, len: 182 aa. Equivalent to Rv0137c, FT len: 182 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 182 aa overlap). Probable msrA, peptide FT methionine sulfoxide reductase (EC 1.8.4.6), equivalent to FT CAC32179.1|AL583926 putative peptide methionine sulfoxide FT from Mycobacterium leprae (177 aa). Highly similar to FT others e.g. CAC18703.1|AL451182 putative peptide methionine FT sulfoxide reductase from Streptomyces coelicolor (172 aa); FT PMSR_SCHPO|Q09859 putative peptide methionine sulfoxide FT reductase from Streptomyces (187 aa), FASTA scores: opt: FT 468, E(): 9.9e-26, (45.6% identity in 158 aa overlap); etc. FT BELONGS TO THE MSRA FAMILY." FT /db_xref="GOA:P0A5L1" FT /db_xref="InterPro:IPR002569" FT /db_xref="UniProtKB/Swiss-Prot:P0A5L1" FT /protein_id="CAD93006.1" FT /translation="MTSNQKAILAGGCFWGLQDLIRNQPGVVSTRVGYSGGNIPNATYR FT NHGTHAEAVEIIFDPTVTDYRTLLEFFFQIHDPTTKDRQGNDRGTSYRSAIFYFDEQQK FT RIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHFVRPGWRL FT PRRTAESALRASLSPELGT" FT CDS 165513..166016 FT /transl_table=11 FT /gene="Mb0143" FT /locus_tag="Mb0143" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0143, -, len: 167 aa. Equivalent to Rv0138, len: FT 167 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 167 aa overlap). Conserved hypothetical FT protein, showing weak similarity to Q10827|YT10_MYCTU FT HYPOTHETICAL 17.0 KDA PROTEIN from Mycobacterium FT tuberculosis (147 aa), FASTA scores: opt: 131, E(): 0.047, FT (31.15% identity in 106 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2S0" FT /protein_id="CAD93007.1" FT /translation="MSASEFSRAELAAAFEKFEKTVARAAATRDWDCWVQHYTPDVEYI FT EHAAGIMRGRQRVRAWIQETMTTFPGSHMVAFPSLWSVIDESTGRIICELGNPMLDPGD FT GSVISATNISIITYAGNGQWCRQEDIYNPLRFLRAAMKWCRKAQELGTLDEDAARWMRR FT HGGP" FT CDS 166017..167039 FT /transl_table=11 FT /gene="Mb0144" FT /locus_tag="Mb0144" FT /product="PUTATIVE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0144, -, len: 340 aa. Equivalent to Rv0139, len: FT 340 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 340 aa overlap). Putative oxidoreductase FT (EC 1.-.-.-), similar to others e.g. O34285|HPNA HPNA FT PROTEIN from Zymomonas mobilis (337 aa), FASTA scores: opt: FT 507, E (): 5.8e-27, (31.1% identity in 328 aa overlap); FT TRE_STRGR|P29782 dtdp-glucose 4,6-dehydratase (328 aa), FT FASTA scores: opt: 254, E(): 2.6e-10, (29.0% identity in FT 307 aa overlap)." FT /db_xref="GOA:Q7U2R9" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U2R9" FT /protein_id="CAD93008.1" FT /translation="MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRS FT IDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNVLD FT VATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYAHDA FT GLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAVGVDDAARALILA FT AERGHNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTG FT KDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVGKDPAAS FT " FT CDS 167100..167480 FT /transl_table=11 FT /gene="Mb0145" FT /locus_tag="Mb0145" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0145, -, len: 126 aa. Equivalent to Rv0140, len: FT 126 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 126 aa overlap). Conserved hypothetical FT protein, similar to others e.g. P74567|D90916_48 FT HYPOTHETICAL 20.8 KDP ROTEIN from Synechocystis sp. (180 FT aa), FASTA scores: opt: 229, E(): 4.7e-10, (36.1% identity FT in 108 aa overlap). Also similar to Rv1056 and Rv1670 from FT Mycobacterium tuberculosis." FT /db_xref="InterPro:IPR007361" FT /db_xref="UniProtKB/TrEMBL:Q7U2R8" FT /protein_id="CAD93009.1" FT /translation="MSNRIVLEPSADHPITIEPTNRRVQVRVNGEVVADTAAALCLQEA FT SYPAVQYIPLADVVQDRLIRTETSTYCPFKGEASYYSVTTDAGDIVDDVMWTYENPYPA FT VAAIAGHVACYPDKAEISIFPG" FT CDS complement(167461..167871) FT /transl_table=11 FT /gene="Mb0146c" FT /locus_tag="Mb0146c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0146c, -, len: 136 aa. Equivalent to Rv0141c, len: FT 136 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 136 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2R7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93010.1" FT /translation="MTPFDDPQAELAWMFLQSLCEGGDLDEGFALLSNDFTYWSIVTRT FT ELDKKTFRRAVERRKQVFEVNIELIRCVNEGETVVVEGHCDGVSADRTRYDSPFVCIFE FT TRDGMIISLREYSDTQSLAEVYPVACATPGRC" FT CDS 167901..168827 FT /transl_table=11 FT /gene="Mb0147" FT /locus_tag="Mb0147" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0147, -, len: 308 aa. Equivalent to Rv0142, len: FT 308 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 308 aa overlap). Conserved hypothetical FT protein, similar, except in N-terminus, to FT AB88922.1|AL353862 hypothetical protein SCE34.20 from FT Streptomyces coelicolor (326 aa)." FT /db_xref="GOA:Q7U2R6" FT /db_xref="UniProtKB/TrEMBL:Q7U2R6" FT /protein_id="CAD93011.1" FT /translation="MRSIDVVVEAVVTFAGAAGFAHTLAPLRRGQQDPCFRVPGDGTIW FT RTSLLPTGPVTARISRAGRDAARCVAWGSGAEEFVDMAPAMLGAADDASDFVPLHPAVA FT AAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAFRSWRLLVSKYGTQAPGPAPPGMR FT VPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLERLVSLPAARAAEALTSLPG FT VGVWTAAETTQRVFGDADAVSVGDYHIPKMIGWTLVGRPVDDAGMLELLEPMRPHRHRV FT VRLLEASGLAREPRRGPRLPVQNIRAL" FT CDS complement(168894..170372) FT /transl_table=11 FT /gene="Mb0148c" FT /locus_tag="Mb0148c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0148c, -, len: 492 aa. Equivalent to Rv0143c, len: FT 492 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 492 aa overlap). Probable conserved FT transmembrane protein, CIC family possibly involved in FT transport of chloride, similar to others and hypothetical FT proteins e.g. O28857 PUTATIVE CHLORIDE CHANNEL from FT Archaeoglobus fulgidus (589 aa), FASTA scores: opt: 966, FT E(): 0, (37.7% identity in 453 aa overlap); FT YADQ_ECOLI|P37019 hypothetical 46.0 kd protein (436 aa), FT FASTA scores: opt: 452, E(): 2.4e-20, (28.0% identity in FT 460 aa overlap)." FT /db_xref="GOA:Q7U2R5" FT /db_xref="InterPro:IPR014743" FT /db_xref="UniProtKB/TrEMBL:Q7U2R5" FT /protein_id="CAD93012.1" FT /translation="MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRLGVSIRSAGYLR FT KWFLLGITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGFARPW FT AIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGRAVLVKMVASALTI FT GSGGSGGREGPTAQISAGFCSLLTRRLNLSNEDGRTAVALGIGAGIGAIFAAPLGGAAL FT GASIPYRDDFDYRNLLPGFIASGTAYAVLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVV FT IGLIAAAVGYLYARVFHASVAITRRLPGGPVLKPAIGGLLVGLLGLPIPQILSSGYGWA FT QLAADRGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWRLG FT ELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVPGAIIAVGIAA FT LLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA" FT CDS 170474..171316 FT /transl_table=11 FT /gene="Mb0149" FT /locus_tag="Mb0149" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /note="Mb0149, -, len: 280 aa. Equivalent to Rv0144, len: FT 280 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 280 aa overlap). Probable FT transcriptional regulator, possibly tetR family. Has region FT similar to others e.g. FT Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID OPERON FT REPRESSOR (GUS OPERON) from Escherichia coli strains K12 FT and O157:H7 (196 aa), FASTA scores: opt: 214, E(): 1.1e-06, FT (26.0% identity in 196 aa overlap). Contains probable FT helix-turn helix motif from aa 109-130 (Score 1463, +4.17 FT SD). COULD BELONG TO THE TETR/ACRR FAMILY OF FT TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7U2R4" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U2R4" FT /protein_id="CAD93013.1" FT /translation="MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGAK FT LTSSVASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQVFSER FT GYDGATFQEIAVRADLTRPAINHYFANKRVLYQEVVEQTHELVIVAGIERARREPTLMG FT RLAVVVDFAMEADAQYPASTAFLATTVLESQRHPELSRTENDAVRATREFLVWAVNDAI FT ERGELAADVDVSSLAETLLVVLCGVGFYIGFVGSYQRMATITDSFQQLLAGTLWRPPT" FT CDS 171405..172358 FT /transl_table=11 FT /gene="Mb0150" FT /locus_tag="Mb0150" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0150, -, len: 317 aa. Equivalent to Rv0145, len: FT 317 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 317 aa overlap). Conserved hypothetical FT protein, highly similar to many e.g. CAC32172.1|AL583926 FT conserved hypothetical protein from Mycobacterium leprae FT (310 aa); and several Mycobacterium tuberculosis proteins FT e.g. Rv0726c, Rv0731c, etc." FT /db_xref="GOA:Q7U2R3" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/Swiss-Prot:Q7U2R3" FT /protein_id="CAD93014.1" FT /translation="MTELDDVSSLPSSRRTAGDTWAITESVGATALGVAAARAVETAAT FT NPLIRDEFAKVLVSSAGTAWARLADADLAWLDGDQLGRRVHRVACDYQAVRTHFFDEYF FT GAAVDAGVRQVVILAAGLDARAYRLNWPAGTVVYEIDQPSVLEYKAGILQSHGAVPTAR FT RHAVAVDLRDDWPAALIAAGFDGTQPTAWLAEGLLPYLPGDAADRLFDMVTALSAPGSQ FT VAVEAFTMNTKGNTQRWNRMRERLGLDIDVQALTYHEPDRSDAAQWLATHGWQVHSVSN FT REEMARLGRAIPQDLVDETVRTTLLRGRLVTPAQPA" FT CDS 172401..173333 FT /transl_table=11 FT /gene="Mb0151" FT /locus_tag="Mb0151" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0151, -, len: 310 aa. Equivalent to Rv0146, len: FT 310 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 310 aa overlap). Conserved hypothetical FT protein, highly similar to others e.g. AC30975.1|AL583924 FT conserved hypothetical protein from Mycobacterium leprae FT (304 aa); and several Mycobacterium tuberculosis proteins FT e.g. Rv0726c, Rv0731c, etc." FT /db_xref="GOA:Q7U2R2" FT /db_xref="InterPro:IPR003455" FT /db_xref="UniProtKB/Swiss-Prot:Q7U2R2" FT /protein_id="CAD93015.1" FT /translation="MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLV FT TNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAGIR FT QVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPADLR FT QDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVH FT GEERRAEMRARFKKVADVLGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDE FT MRRVGRWVEGVPMADDPTAFAEFVTAERL" FT CDS 173428..174948 FT /transl_table=11 FT /gene="Mb0152" FT /locus_tag="Mb0152" FT /product="PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDANT" FT /EC_number="1.2.1.-" FT /note="Mb0152, -, len: 506 aa. Equivalent to Rv0147, len: FT 506 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 506 aa overlap). Probable aldehyde FT dehydrogenase (NAD+) dependant (EC 1.2.1.-), similar to FT others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric FT NADP-preferring) (452 aa), FASTA scores: opt: 1291, E(): 0, FT (43.9% identity in 453 aa overlap). Also similar to several FT Mycobacterium tuberculosis aledehyde dehydrogenases e.g. FT Rv0768, Rv2858c, etc. Contains PS00687 aldehyde FT dehydrogenases glutamic acid active site, and PS00070 FT aldehyde dehydrogenases cysteine active site. BELONGS TO FT THE ALDEHYDE DEHYDROGENASES FAMILY." FT /db_xref="GOA:Q7U2R1" FT /db_xref="HSSP:1AD3" FT /db_xref="InterPro:IPR016162" FT /db_xref="UniProtKB/TrEMBL:Q7U2R1" FT /protein_id="CAD93016.1" FT /translation="MSDRVKAVAPPDGRTMMTTESVARKTQKSETEAPREPAPVSDEKQ FT TDVAKTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLDRNPFEAY FT LADIATTSAEAKYAAKRVRRWMRRRYLLLEVPQLPGRGWVEYEPYGTVLIIGAWNYPFY FT LTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTELVYRYLDTEAIAVVQGDGAVSQELIA FT QGFDRVMFTGGTEIGRKVYEGAAPHLTPVTLELGGKSPVIVAADADVDVAAKRIAWIKL FT LNAGQTCVAPDYVLADATVRDELVSKITAALTKFRSGAPQGMRIVNQRQFDRLSGYLAA FT AKTDAAADGGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVTVKSLDD FT AIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQVSTAKLPFGGVGASG FT MGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPPYTERAIKVARRLF" FT CDS 175023..175883 FT /transl_table=11 FT /gene="Mb0153" FT /locus_tag="Mb0153" FT /product="PROBABLE SHORT-CHAIN TYPE FT DEHYDROGENASE/REDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0153, -, len: 286 aa. Equivalent to Rv0148, len: FT 286 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 286 aa overlap). Probable short-chain FT dehydrogenase (EC 1.-.-.-), similar to others, in FT particular Estradiol 17 beta-dehydrogenases (EC 1.1.1.62), FT e.g. DHB4_MOUSE|P51660 estradiol 17 beta-dehydrogenase 4 FT (735 aa), FASTA scores: opt: 952, E(): 0, (52.5% identity FT in 276 aa overlap). Contains PS00061 Short-chain alcohol FT dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY." FT /db_xref="GOA:Q7U2R0" FT /db_xref="HSSP:1GZ6" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U2R0" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93017.1" FT /translation="MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDGT FT GAGSAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILR FT DGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLFGNFGQTN FT YGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDILPPEVLEKLTPEFVAPVV FT AYLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQDVAARWAEITDLSGAKI FT AGFKL" FT CDS 175890..176858 FT /transl_table=11 FT /gene="Mb0154" FT /locus_tag="Mb0154" FT /product="PUTATIVE QUINONE OXIDOREDUCTASE (NADPH:QUINONE FT OXIDOREDUCTASE) (ZETA-CRYSTALLIN)" FT /EC_number="1.6.5.-" FT /note="Mb0154, -, len: 322 aa. Equivalent to Rv0149, len: FT 322 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 322 aa overlap). Putative quinone FT oxidoreductase (EC 1.6.5.-), similar to others FT oxidoreductases e.g. Q08257 quinone oxidoreductase (EC FT 1.6.5.5) (329 aa), FASTA scores: opt: 397, E(): 3.2e-18, FT (28.4% identity in 328 aa overlap); SCHCOADH_4 from FT Streptomyces coelicolor. Also similar to many proteins from FT Mycobacterium tuberculosis. Contains PS01162 Quinone FT oxidoreductase / zeta-crystallin signature. BELONG TO THE FT ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE FT OXIDOREDUCTASE SUBFAMILY." FT /db_xref="GOA:Q7U2Q9" FT /db_xref="HSSP:1IYZ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U2Q9" FT /protein_id="CAD93018.1" FT /translation="MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLL FT LTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHVGERVSAFGVLGGYAEQIAVPVANV FT VRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAKAMQ FT AGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGPTFDD FT ALGVLAIDGKLLLIGFAAGAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGL FT NQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP" FT CDS complement(176855..177142) FT /transl_table=11 FT /gene="Mb0155c" FT /locus_tag="Mb0155c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0155c, -, len: 95 aa. Equivalent to Rv0150c, len: FT 95 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 95 aa overlap). Conserved hypothetical FT protein, showing some similarity with C-terminus of FT O53949|Rv1800|MTV049.22 PPE-FAMILY PROTEIN from FT Mycobacterium tuberculosis (655 aa), FASTA score: (36.5% FT identity in 104 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2Q8" FT /protein_id="CAD93019.1" FT /translation="MLTLPDDRAPTGLPDPGIEALAHTKIASTISTVVADGYAVVLSTA FT DIANSLLANAIGYPIAASVALVTPAAGANSSCWPADPSQHHRIAESRACA" FT CDS complement(177733..179499) FT /transl_table=11 FT /gene="PE1" FT /locus_tag="Mb0156c" FT /product="PE FAMILY PROTEIN" FT /note="Mb0156c, PE1, len: 588 aa. Equivalent to Rv0151c, FT len: 588 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 588 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, with N-terminal FT region similar to others e.g. MTV032_2 PE_PGRS family from FT Mycobacterium tuberculosis (468 aa), FASTA scores: opt: FT 1125, E(): 0, (46.3% identity in 456 aa overlap); FT MTCY493_24 from M. tuberculosis FASTA score: (42.5% FT identity in 558 aa overlap). Also similar to upstream ORF FT MTCI5.26c FASTA score: (54.7% identity in 464 aa overlap). FT Also shows similarity to C-terminal part of some PPE family FT proteins e.g. MTV049_21 from Mycobacterium tuberculosis FT FASTA score: (41.5% identity in 591 aa overlap)." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/TrEMBL:Q7U2Q7" FT /protein_id="CAD93020.1" FT /translation="MAPFGFTPKARHNRGVALRSTYRLDRWVMGPVDKEGWGLSYVFAQ FT PSVLAAAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQFQAIS FT AQVAAFHNEFTQRLAAAANAFVNAEATNTSALVQEATAGLFKPTSPPVLPPMFNQNTAI FT IMGGTGSPIPTPSYVNAITTLFIDPVVSNPVVKALVTPEELYPITGVKSLPFQTSVQLG FT LQILDGAIWEQINAGNHVTVFGYSQSAVIASLEMQHLISLGPNAPSPSQLNFILIGNEM FT NPNGGILARIPGLNVTTLGLPFYGATPDNPYPTTTYTLEYDGFADFPRYPLNVLSDINA FT VFGILTVHTTYADLTPAQIASATQLPTQGTTSNTYYIIETEHLPLLAPLRAIPVIGPPL FT AALVEPNLEVIVNLGYGDPRFGYSTSPANVPTPFGLFPDVPASVVADALVAGTQQGVND FT FMVELPAALNTLPQTPMPAFPPYVPTLLPPPPPPQPATLINIADTFASVVSTGYSILLP FT TADLGLAFVTILPAYDLTLFVNQLAAGNLRAAIELPLAATIGLAALGGMIEFIAIVVTL FT ADITQQLQSFSI" FT CDS complement(179509..181086) FT /transl_table=11 FT /gene="PE2" FT /locus_tag="Mb0157c" FT /product="PE FAMILY PROTEIN" FT /note="Mb0157c, PE2, len: 525 aa. Equivalent to Rv0152c, FT len: 525 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 525 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, similar to ORF FT downstream Z92770|MTCI5_25 (588 aa), FASTA scores: opt: FT 1492, E(): 0, (54.7% identity in 464 aa overlap); and to FT many other PE family type members." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/TrEMBL:Q7U2Q6" FT /protein_id="CAD93021.1" FT /translation="MRCRPPSRNRSAHTARNTRPCSLKSRRFTVRFHQTLAAAANSYAD FT AEAAIASTRQNQLAVPAAAPTPAAAAMIPPFPANLTTLFFGPTGIPLPPPSMLTPPIRC FT RSVRRALQAVFTPEELYPLTGVRSLVLNTSVEEGLTILHDAIMVELATTGNAVTVFGWS FT QSAIIASLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLTFYG FT ATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHTKYLDLTPAQVEGAT FT KLPTSPGYTGVTDYYIIRTENRPLLQPLRAVPVIGDPLADLIQPNLKVIVNLGYGDPNY FT GYSTSYADVRTPFGLWPNVPPQVIADALAAGTQEGILDFTADLQALSAQPLTLPQIQLP FT QPADLVAAVAAAPTPAEVVNTLARIISTNYAVLLPTVDIALALVTTLPLYTTQLFVRQL FT AAGNLINAIGYPLAATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPP FT TTVYRPRQ" FT CDS complement(181345..182175) FT /transl_table=11 FT /gene="ptbB" FT /locus_tag="Mb0158c" FT /standard_name="MPtpB" FT /product="PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB FT (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase)" FT /EC_number="3.1.3.48" FT /note="Mb0158c, ptbB, len: 276 aa. Equivalent to Rv0153c, FT len: 276 aa, from Mycobacterium tuberculosis strain H27Rv, FT (99.6% identity in 276 aa overlap). ptbB (alternate gene FT name: MPtpB), protein-tyrosine-phosphatase (see citation FT below) (EC 3.1.3.48), showing some similarity to several FT protein-tyrosine phosphatases, polyketide synthase and FT aminotransferase e.g. Q05918|IPHP_NOSCO|IPH FT PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune FT (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E(): FT 0.0096, (26.8% identity in 269 aa overlap); etc. Supposed a FT secreted protein." FT /db_xref="GOA:Q7U2Q5" FT /db_xref="InterPro:IPR000387" FT /db_xref="UniProtKB/TrEMBL:Q7U2Q5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93022.1" FT /translation="MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLR FT RLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTN FT GGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAG FT KDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTF FT TKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG" FT CDS complement(182177..183388) FT /transl_table=11 FT /gene="fadE2" FT /locus_tag="Mb0159c" FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE2" FT /EC_number="1.3.99.-" FT /note="Mb0159c, fadE2, len: 403 aa. Equivalent to Rv0154c, FT len: 403 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 403 aa overlap). Probable fadE2, FT acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. FT C-terminal region of O01590 ACYL-CoA DEHYDROGENASE (974 FT aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in FT 402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase FT (short-chain) (383 aa), FASTA score: (35.0% identity in 306 FT aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FT FAMILY." FT /db_xref="GOA:Q7U2Q4" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:Q7U2Q4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93023.1" FT /translation="MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRAAGPADHTAPPII FT EELKTKAKDRGLWNLFLSAESGLTNLEYAPLAEMTGWSMEIAPEALNCAAPDTGNMEIL FT HMFGTEQQRAQWLRPLLDGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWW FT TSGAADPRCKILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHGHCE FT IDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALMVNRVRNRVA FT FGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQHGNKEARHLVAMIKAVAPRVA FT CDVIDRAIQVHGAAGVSDDTPLARLYGWHRAMRIFDGPDEVHLRSIARAELSREKSTFA FT AAVT" FT CDS 183812..184912 FT /transl_table=11 FT /gene="pntAa" FT /locus_tag="Mb0160" FT /standard_name="pntAA" FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) FT PNTAa [FIRST PART; CATALYTIC PART] (PYRIDINE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT ALPHA)" FT /EC_number="1.6.1.2" FT /note="Mb0160, pntAa, len: 366 aa. Equivalent to Rv0155, FT len: 366 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 366 aa overlap). Probable pntAa, first FT part of NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2), FT similar to N-terminus of others e.g. FT PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase FT subunit alpha from Escherichia coli strain K12 (510 aa), FT FASTA scores: opt: 921, E(): 0, (42.1% identity in 361 aa FT overlap); PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT PNTAA (EC 1.6.1.1)." FT /db_xref="GOA:Q7U2Q3" FT /db_xref="HSSP:1PTJ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q7U2Q3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93024.1" FT /translation="MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEA FT GAGERALLPDELYTAVGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRNAD FT NSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPMLTT FT AAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGIS FT ASGEGGYARELTDDERAQQQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPG FT SVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPATMPEHASELYSKNITALLDLL FT IKDGRLAPDFDDEVIAQSCVTRGKDS" FT CDS 184913..185245 FT /transl_table=11 FT /gene="pntAb" FT /locus_tag="Mb0161" FT /standard_name="pntAB" FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) FT PNTAb [SECOND PART; INTEGRAL MEMBRANE PROTEIN] (PYRIDINE FT NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE FT NUCLEOTIDE TRANSHYDROGENASE SUBUNIT ALPHA)" FT /note="Mb0161, pntAb, len: 110 aa. Equivalent to Rv0156, FT len: 110 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.1% identity in 110 aa overlap). Probable pntAb, second FT part of NAD(P) transhydrogenase subunit alpha, integral FT membrane protein, similar to C-terminus of others e.g. FT Q59764 NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT FT PNTAB (139 aa), FASTA scores: opt: 247, E(): 1.9e-11, FT (45.5% identity in 88 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2Q2" FT /protein_id="CAD93025.1" FT /translation="MCNELLENLAILVLSGFVGFAVISKVPNTLHTPLMSGTNAIHGIV FT VLGALVVFGEIEHPSLVLQVILFVAVVFGTLNVIGGFIVTDRMLGMFKAKKPAVPAKPD FT RDEALR" FT CDS 185242..186669 FT /transl_table=11 FT /gene="pntB" FT /locus_tag="Mb0162" FT /product="PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) FT PNTB [INTEGRAL MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA)" FT /EC_number="1.6.1.1" FT /note="Mb0162, pntB, len: 475 aa. Equivalent to Rv0157, FT len: 475 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 475 aa overlap). Probable pntB, FT pyridine nucleotide transhydrogenase (nicotinamide FT nucleotide transhydrogenase) subunit beta (EC 1.6.1.1), FT integral membrane protein, similar to others e.g. Q59763 FT PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE FT TRANSHYDROGENASE SUBUNIT BETA from HODOSPIRILLUM RUBRUM FT (464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity FT in 472 aa overlap); FT P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P) FT TRANSHYDROGENASE SUBUNIT BETA from Escherichia coli strains FT K12 and O157:H7 (462 aa)." FT /db_xref="GOA:Q7U2Q1" FT /db_xref="HSSP:1NM5" FT /db_xref="InterPro:IPR012136" FT /db_xref="UniProtKB/TrEMBL:Q7U2Q1" FT /protein_id="CAD93026.1" FT /translation="MNLHYLVEILYIISFSLFIYGLMGLTGPKTAVRGNLIAAAGMTIA FT VAATLVMIRHTSQWPLIIAGLVVGVVLGVPPARLTKMTAMPQLVAFFNGVGGGTVALIA FT LSEFIDTTGFSAFQHGESPTVHIVVASLFAAIIGSISFWGSIVAFGKLQEIISGRPIGL FT GKAQQPINLLLLAVAVAAAVVIGLHAHPGSGGVALWWMIGLLVAAGVLGLMVVLPIGGA FT DMPVVISMLNAMTGLSAAAAGLALNNTAMIVAGMIVGASGSILTNLMAKAMNRSIPAIV FT AGGFGGGGVAPSGGGDDKHVKATSAADAAIQMAYANQVIVVPGYGLAVAQAQHAVKDLA FT TLLEDRGVPVKYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFARTDVTIVIG FT ANDVTNPAARNETSSPIYGMPILNVDKSRSVIVLKRSMNSGFAGIDNPLFYADGTTMLF FT GDAKKSVTEVSEELKAL" FT CDS 186975..187619 FT /transl_table=11 FT /gene="Mb0163" FT /locus_tag="Mb0163" FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (POSSIBLY TETR-FAMILY)" FT /note="Mb0163, -, len: 214 aa. Equivalent to Rv0158, len: FT 214 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 214 aa overlap). Probable FT transcriptional regulator, possibly TetR family, showing FT weak similarity to various transcriptional activators and FT repressors e.g. P32398|YIXD_BACSU|YHGD HYPOTHETICAL FT TRANSCRIPTIONAL REGULATORY PROTEIN from Bacillus subtilis FT (191 aa), FASTA scores: opt:172, E(): 2.4e-05, (23.0% FT identity in 191 aa overlap). Contains helix-turn-helix FT motif at aa 32-53 (Score 1296, +3.60 SD). COULD BELONG TO FT THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS." FT /db_xref="GOA:Q7U2Q0" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U2Q0" FT /protein_id="CAD93027.1" FT /translation="MPSDTSPNGLSRREELLAVATKLFAARGYHGTRMDDVADVIGLNK FT ATVYHYYASKSLILFDIYRQAAEGTLAAVHDDPSWTAREALYQYTVRLLTAIASNPERA FT AVYFQEQPYITEWFTSEQVAEVREKEQQVYEHVHGLIDRGIASGEFYECDSHVVALGYI FT GMTLGSYRWLRPSGRRTAKEIAAEFSTALLRGLIRDESIRNQSPLGTRKET" FT CDS complement(187623..189029) FT /transl_table=11 FT /gene="PE3" FT /locus_tag="Mb0164c" FT /product="PE FAMILY PROTEIN" FT /note="Mb0164c, PE3, len: 468 aa. Equivalent to Rv0159c, FT len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 468 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, similar to many other FT PE proteins e.g. O06828 from Mycobacterium tuberculosis FT (528 aa), FASTA scores: opt: 1163, E(): 0, (45.8% identity FT in 467 aa overlap). Also highly similar to upstream FT MTV032_3, and to MTCI5_25, MTCI5_26, MTV049_ 21, FT MTCY1A10_26, etc." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U2P9" FT /protein_id="CAD93028.1" FT /translation="MSYVIAAPEMLATAAADVDGIGSAIRAASASAAGPTTGLLAAAAD FT EVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTAGS FT SGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTPEQW FT WPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMALPPG FT QAPDPSRLAFTLIGNINNPNGGVLERYVGLYLTFLDMSFNGATPPDSPYQTYMYTGQYD FT GYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTHYYMFLT FT QDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPINPIAVAS FT ALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTELSVLSGALG FT SVARLIPPIA" FT CDS complement(189121..190629) FT /transl_table=11 FT /gene="PE4" FT /locus_tag="Mb0165c" FT /product="PE FAMILY PROTEIN" FT /note="Mb0165c, PE4, len: 502 aa. Equivalent to Rv0160c, FT len: 502 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 502 aa overlap). Member of the FT Mycobacterium tuberculosis PE family, similar to many other FT PE proteins e.g. Z92770|MTCI5_26c from M. tuberculosis (525 FT aa), FASTA scores: opt: 816, E(): 0, (41.4% identity in 367 FT aa overlap); C-terminal region of O06801|RV1768|MTCY28.34 FT from Mycobacterium tuberculosis (618 aa), FASTA scores: FT opt: 417, E(): 6.7e-18, (53.5% identity in 142 aa overlap). FT Also highly similar to downstream ORF MTV032_2." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q7U2P8" FT /protein_id="CAD93029.1" FT /translation="MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGD FT EVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHALDT FT INAPIRTLLGRTPLSPNGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVTDIN FT KAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTTVNNQLALDNKV FT VAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDV FT PFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPELMATQV FT DNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYA FT DYGPGGNYADIPTPAGLFSIPNPFAVTYYLIKGSLQAPYGAIVEIGVEAGLIGPEWFPD FT SYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILHLIPPPVFT" FT CDS 190797..192146 FT /transl_table=11 FT /gene="Mb0166" FT /locus_tag="Mb0166" FT /product="PUTATIVE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0166, -, len: 449 aa. Equivalent to Rv0161, len FT 449 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 449 aa overlap). Possible FT oxidoreductase (EC 1.-.-.-), similar to hypothetical FT proteins and various oxidoreductases e.g. AIP2_YEAST|P46681 FT actin interacting protein 2 (530 aa), FASTA scores: opt: FT 356, E (): 0, (33.3% identity in 357 aa overlap); FT DLD1_YEAST|P32891 d-lactate dehydrogenase (cytochrome) (587 FT aa), FASTA scores: opt: 311, E(): 2.5e-20, (27.9% identity FT in 366 aa overlap). Also similar to other Mycobacteria FT proteins e.g. MTCY339.30c from M. tuberculosis FASTA score: FT (29.4% identity in 357 aa overlap); MLCL622.30c from FT Mycobacterium tuberculosis (449 aa)." FT /db_xref="GOA:Q7U2P7" FT /db_xref="InterPro:IPR016167" FT /db_xref="UniProtKB/TrEMBL:Q7U2P7" FT /protein_id="CAD93030.1" FT /translation="MLTSLVSAVGSHHVTTDPDVLAGRSVDHTGRYRGRASALVRPGSA FT EEVAEVLRVCRDAGAYVTVQGGRTSLVAGTVPEHDDVLLSTERLCVVSDVDTVERRIEI FT GAGVTLAAVQHAASTAGLVFGVDLSARDTATVGGMASTNAGGLRTVRYGNMGEQVVGLD FT VALPDGTVLRRHSRVRRDNTGYDLPALFVGAEGTLGVITALDLRLHPTPSHRVTAVCGF FT AELAALVDAGRMFRDVEGIAALELIDGRAAALTREHLGVRPPVEADWLLLVELAADHDQ FT TDRLADLLGGARMCGEPAVGVDAAAQQRLWRTRESLAEVLGVYGPPLKFDVSLPLSAIS FT GFARDAVALVHRHVPDSPEALPLLFGHIGEGNLHLNVLRCPPDREPALYAKMMGLIAEC FT GGNVSSEHGVGSRKRAYLGMSRQANDVAAMRRVKAALDPTGYLNAAVLFD" FT CDS complement(192174..193325) FT /transl_table=11 FT /gene="adhE1" FT /locus_tag="Mb0167c" FT /product="PUTATIVE ZINC-TYPE ALCOHOL DEHYDROGENASE (E FT SUBUNIT) ADHE" FT /EC_number="1.1.1.1" FT /note="Mb0167c, adhE1, len: 383 aa. Equivalent to Rv0162c, FT len: 383 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 383 aa overlap). Probable adhE1, FT zinc-type alcohol dehydrogenase (EC 1.1.1.1), similar to FT others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha FT chain (374 aa), FASTA scores: opt: 619, E(): 0, (34.7% FT identity in 363 aa overlap). Also similar to other alcohol FT dehydrogenases from Mycobacterium tuberculosis e.g. FT MTCY369.06c FASTA score: (34.0% identity in 365 aa FT overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa FT overlap). Contains PS00059 Zinc-contain ingalcohol FT dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING FT ALCOHOL DEHYDROGENASE FAMILY, CLASS-I SUBFAMILY. COFACTOR: FT ZINC." FT /db_xref="GOA:Q7U2P6" FT /db_xref="HSSP:1HT0" FT /db_xref="InterPro:IPR013154" FT /db_xref="UniProtKB/TrEMBL:Q7U2P6" FT /protein_id="CAD93031.1" FT /translation="MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPP FT DRGEVLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAVGQRVV FT LVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRGGRPVYHHLGVSGFATH FT VVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQSVAVVGLGGVGMAAV FT LTALTYTDVRVVAVDQLPEKLSAAKALGAHEIYTPQQATAGGVKAAVVVEAVGHPAALH FT TAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSLW FT QSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL" FT CDS 193307..193762 FT /transl_table=11 FT /gene="Mb0168" FT /locus_tag="Mb0168" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0168, -, len: 151 aa. Equivalent to Rv0163, len: FT 151 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 151 aa overlap). Conserved hypothetical FT protein, similar to others e.g. Q44017 HYPOTHETICAL 16.6 FT KDA PROTEIN IN GBD 5'REGION (ORF6)from Alcaligenes FT eutrophus (145 aa), FASTA scores: opt: 155, E(): 0.0002, FT (26.6% identity in 139 aa overlap). Also weak similary with FT MTV008.31c|Rv2475c|B70867 from Mycobacterium tuberculosis FT (138 aa)." FT /db_xref="InterPro:IPR006683" FT /db_xref="UniProtKB/TrEMBL:Q7U2P5" FT /protein_id="CAD93032.1" FT /translation="MAALPAPEKLLRSDFPVLWPVGTRWADNDMFGHLNNAVYYQLFDT FT AINAWINTSTGVDPLAMPVLGIVAESGCRYFSELRFPESLMVGLAVTRLGRSSVTYRLG FT VFKEPDDAGVITALGHWVHVYVDRTSRRPVPIPEAIRSLLSTACVSG" FT CDS 193816..194301 FT /transl_table=11 FT /gene="TB18.5" FT /locus_tag="Mb0169" FT /product="CONSERVED HYPOTHETICAL PROTEIN TB18.5" FT /note="Mb0169, TB18.5, len: 161 aa. Equivalent to Rv0164, FT len: 161 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 161 aa overlap). TB18.5, conserved FT hypothetical protein, equivalent to CAB08818.1|Z95398 FT HYPOTHETICAL PROTEIN from Mycobacterium leprae (156 aa) FT FASTA scores: opt: 762, E(): 0, (76.3% identity in 152 aa FT overlap). Some similarity to Rv2185c, Rv0854, Rv0857 from FT Mycobacterium tuberculosis. Alternative start codon has FT been suggested. 3' part corrected since first submission FT (-24 aa)." FT /db_xref="InterPro:IPR005031" FT /db_xref="UniProtKB/TrEMBL:Q7U2P4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93033.1" FT /translation="MTAISCSPRPRYASRMPVLSKTVEVTADAASIMAIVADIERYPEW FT NEGVKGAWVLARYDDGRPSQVRLDTAVQGIEGTYIHAVYYPGENQIQTVMQQGELFAKQ FT EQLFSVVATGAASLLTVDMDVQVTMPVPEPMVKMLLNNVLEHLAENLKQRAEQLAAS" FT CDS complement(194315..195130) FT /transl_table=11 FT /gene="Mb0170c" FT /locus_tag="Mb0170c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT /note="Mb0170c, -, len: 271 aa. Equivalent to 5' end of FT Rv0165c, len: 264 aa, from Mycobacterium tuberculosis FT strain H37Rv, (99.1% identity in 215 aa overlap). Possible FT transcriptional regulator, GntR family, showing some FT similarity to several e.g. NTRA_CHELE|P54988 nta operon FT transcriptional regulator (231 aa), FASTA scores: opt: 154, FT E(): 0.00058, (32.0% identity in 125 aa overlap); FT P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL FT REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU FT GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). FT Also similar to Rv0043c from Mycobacterium tuberculosis. FT SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL FT REGULATORS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0165c exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a 2 bp FT insertion (*-cc) leads to a product with a different COOH FT terminus." FT /db_xref="GOA:Q7U2P3" FT /db_xref="InterPro:IPR011711" FT /db_xref="UniProtKB/TrEMBL:Q7U2P3" FT /protein_id="CAD93034.1" FT /translation="MIKHDVVWVTLWPERPNNKPPPSPRQVPGNPGPTLKVLASHVNAP FT LSAKPRSQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREAL FT LKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQATIAQELATSATAHITDVEIDELDR FT INNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLAWFLLNAARYMPAQVFAADPRW FT GADAVNSHRQLIAALRRRDTAAVIEHTVWQFTDGARRLTEALAETEVFG" FT CDS complement(194334..194513) FT /pseudo FT /transl_table=11 FT /gene="Mb0171c" FT /locus_tag="Mb0171c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN FT (PROBABLY GNTR-FAMILY)" FT /note="Mb0171c, -, len: 59 aa. Equivalent to 3' end of FT Rv0165c, len: 264 aa, from Mycobacterium tuberculosis FT strain H37Rv, (96.5% identity in 57 aa overlap). Possible FT transcriptional regulator, GntR family, showing some FT similarity to several e.g. NTRA_CHELE|P54988 nta operon FT transcriptional regulator (231 aa), FASTA scores: opt: 154, FT E(): 0.00058, (32.0% identity in 125 aa overlap); FT P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL FT REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU FT GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). FT Also similar to Rv0043c from Mycobacterium tuberculosis. FT SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL FT REGULATORS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0165c exists as a single gene. FT In Mycobacterium bovis, a frameshift due to a 2 bp FT insertion (*-cc) leads to a product with a different COOH FT part. Mb0171c corresponds to the remnant COOH part of FT Rv0165c." FT CDS 195185..196849 FT /transl_table=11 FT /gene="fadD5" FT /locus_tag="Mb0172" FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD5 FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb0172, fadD5, len: 554 aa. Equivalent to Rv0166, FT len: 554 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 554 aa overlap). Probable fadD5, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many eg FT LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 FT aa), FASTA scores: opt: 612, E(): 0, (29.4% identity in 534 FT aa overlap). Also similar to many other fatty-acid-CoA FT ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c FT FASTA score: (35.3% identity in 487 aa overlap), MTV013_10, FT MTY25D10_30, etc. Contains PS00455 putative AMP-binding FT domain signature." FT /db_xref="GOA:Q7U2P2" FT /db_xref="HSSP:1BA3" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U2P2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93036.1" FT /translation="MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPAL FT RFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAANMIGAIAV FT PLNFRLTPTEIAVLVEDCAAHVMLTEAALAPVAIGVRNIQPLLSVIVVAGGSSQDSVFG FT YEDLLNEAGDVHEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGAN FT INSDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFLV FT PAQWQAVCTEQQARPRDLRLRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSPV FT TCMLLGEDAIAKRGSVGRVIPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPE FT ATAEAFAGGWFHSGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAE FT VAVIGRADEKWGEVPIAVAAVTNDDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPA FT GKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL" FT CDS 197053..197850 FT /transl_table=11 FT /gene="yrbE1A" FT /locus_tag="Mb0173" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE1A" FT /note="Mb0173, yrbE1A, len: 265 aa. Equivalent to Rv0167, FT len: 265 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 265 aa overlap). yrbE1A, hypothetical FT unknown integral membrane protein, part of mce1 operon and FT member of YrbE family (see citations below for more FT information), highly similar to Mycobacterium tuberculosis FT proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); FT O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly FT similar or similar to conserved hypothetical integral FT membrane proteins of yrbEA type, e.g. NP_302654.1|NC_002677 FT conserved membrane protein from Mycobacterium leprae (267 FT aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from FT Haemophilus influenzae (261 aa), FASTA scores: opt: 328, FT E(): 1.8e-15, (26.6% identity in 244 aa overlap); etc." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:Q7U2P1" FT /protein_id="CAD93037.1" FT /translation="MTTSTTLGGYVRDQLQTPLTLVGGFFRMCVLTGKALFRWPFQWRE FT FILQCWFIMRVGFLPTIMVSIPLTVLLIFTLNILLAQFGAADISGSGAAIGAVTQLGPL FT TTVLVVAGAGSTAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVLASMLVATLLNGL FT VITVGLVGGFLFGVYLQNVSGGAYLATLTLITGLPEVVIATIKAATFGLIAGLVGCYRG FT LTVRGGSKGLGTAVNETVVLCVIALFAVNVILTTIGVRFGTGR" FT CDS 197852..198721 FT /transl_table=11 FT /gene="yrbE1B" FT /locus_tag="Mb0174" FT /product="CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN FT YRBE1B" FT /note="Mb0174, yrbE1B, len: 289 aa. Equivalent to Rv0168, FT len: 289 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 289 aa overlap). yrbE1B, hypothetical FT unknown integral membrane protein, part of mce1 operon and FT member of YrbE family (see citations below for more FT information), highly similar to Mycobacterium tuberculosis FT proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); FT O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly FT similar to conserved hypothetical integral membrane FT proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 FT conserved membrane protein from Mycobacterium leprae (289 FT aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from FT Haemophilus influenzae (261 aa), FASTA scores: opt: 223, FT E(): 7.6e-07, (23.7% identity in 257 aa overlap); etc." FT /db_xref="InterPro:IPR003453" FT /db_xref="UniProtKB/TrEMBL:Q7U2P0" FT /protein_id="CAD93038.1" FT /translation="MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIGQ FT IAHALRYYRKETLRLIAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGNIG FT VEAFTGFFAALINVRIAGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIKSIS FT FLASTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPDDVFW FT SFLEALIITAIVMVSHCYYGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAALALYGV FT DPNFNLTV" FT CDS 198726..200090 FT /transl_table=11 FT /gene="mce1A" FT /locus_tag="Mb0175" FT /standard_name="mce1" FT /product="MCE-FAMILY PROTEIN MCE1A" FT /note="Mb0175, mce1A, len: 454 aa. Equivalent to Rv0169, FT len: 454 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.6% identity in 454 aa overlap). mce1A; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); FT O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also FT highly similar to others e.g. FT AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry FT protein from Mycobacterium bovis BCG (454 aa); FT NP_302656.1|NC_002677 putative cell invasion protein from FT Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene FT product from Mycobacterium avium (88 aa) (similarity on FT C-terminus); CAC12798.1|AL445327 putative secreted protein FT from Streptomyces coelicolor (418 aa); etc. Note that FT equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901 FT Mcep protein from Mycobacterium tuberculosis (432 aa). FT Contains a very hydrophobic region around residues 20-35. FT Note that previously known as mce1." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:Q7U2N9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93039.1" FT /translation="MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKT FT QLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIHLIPA FT NVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVTTEINTLFQTLTSIAEKV FT DPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDLNSRMPQSRHDIQQLAALGDVYA FT DAAPDLFDFLDSSVTTARTINAQQAELDSALLAAAGFGNTTADVFDRGGPYLQRGVADL FT VPTATLLDTYSPELFCTIRNFYDADPLAKAAAGGGNGYSLRTNSEILSGIGISLLSPLA FT LATNGAAIGIGLVAGLIASPLAVAANLAGALPGIVGGAPNPYTYPENLPRVNARGGPGG FT APGCWQPITRDLWPAPYLVMDTGASLAPYNHMEVGSPYAVEYVWGRQVGDNTINP" FT CDS 200087..201127 FT /transl_table=11 FT /gene="mce1B" FT /locus_tag="Mb0176" FT /standard_name="mceD" FT /product="MCE-FAMILY PROTEIN MCE1B" FT /note="Mb0176, mce1B, len: 346 aa. Equivalent to Rv0170, FT len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 346 aa overlap). mce1B (alternate gene FT name: mceD); belongs to 24-membered Mycobacterium FT tuberculosis Mce protein family (see citations below for FT more information), highly similar to Mycobacterium FT tuberculosis proteins O07788|Rv0590|MTCY19H5.32c|mce2B (275 FT aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also FT highly similar to others e.g. NP_302657.1|NC_002677 FT putative secreted protein from Mycobacterium leprae (346 FT aa); CAC12797.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (354 aa); etc. Contains hydrophobic FT region in N-terminal 30 residues. In Escherichia coli, FT N-terminal part is functional and directs export of a FT leaderless beta-lactamase into the periplasm (see seventh FT citation)." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:Q7U2N8" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93040.1" FT /translation="MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSN FT VSGLRQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYSDLIG FT NRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVFRALDPAKVNNIAN FT ALITVFQGQGGTINDTLDQTAQLTSQIAERDQAIGEVVKNLNIVLDTTVKHRKEFDETV FT NNLENLITGLRNHSDQLAGGLAHISNGAGTVADLLAENRTLVRKAVSYLDAIQQPVIDQ FT RVELDDLLHKTPTALTALGRANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVKLFSQPT FT GRCTPQ" FT CDS 201124..202671 FT /transl_table=11 FT /gene="mce1C" FT /locus_tag="Mb0177" FT /product="MCE-FAMILY PROTEIN MCE1C" FT /note="Mb0177, mce1C, len: 515 aa. Equivalent to Rv0171, FT len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 515 aa overlap). mce1C; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); FT O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly FT similar to others e.g. NP_302658.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (519 aa); FT CAC12796.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (351 aa); etc. Weakly similar to FT downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA FT score: (24.6% identity in 552 aa overlap). Contains FT possible signal sequence and highly proline-rich FT C-terminus." FT /db_xref="InterPro:IPR008360" FT /db_xref="UniProtKB/TrEMBL:Q7U2N7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93041.1" FT /translation="MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQ FT FTDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNTIGTESRLAIRTDTILG FT RKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKAASGWDIETVKRSLNVLSE FT TVDQTYPHLSAALDGVAKFSDTIGKRDEQITHLLAQANQVASILGDRSDQVDRLLVNAK FT TLIAAFNERGRAVDALLGNISAFSAQVQNLINDNPNLNHVLEQLRILTDLLVDRKEDLA FT ETLTILGRFSASFGETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAG FT LPAYRWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADGLPRPWDPL FT PCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAPGLPIAGRPGEVPPNVPGTPVPIPQ FT EAPPGARTLPLGPAPGPAPPPAAPGPPAPPGPGPQLPAPFINPGGTGGSGVTGGSEN" FT CDS 202668..204260 FT /transl_table=11 FT /gene="mce1D" FT /locus_tag="Mb0178" FT /product="MCE-FAMILY PROTEIN MCE1D" FT /note="Mb0178, mce1D, len: 530 aa. Equivalent to Rv0172, FT len: 530 aa, fromMycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 530 aa overlap). mce1D; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); FT O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly FT similar to others e.g. NP_302659.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (531 aa); FT CAC12795.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (337 aa); etc. Hydrophobic region FT at N-terminus." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:Q7U2N6" FT /protein_id="CAD93042.1" FT /translation="MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLT FT NNTVVAYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPANASAV FT ILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRDSVSHIIDELGPTP FT EQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALNALNEGRGDFFAVVRSLALFVNA FT LHQDDQQFVALNKNLAEFTDRLTHSDADLSNAIQQFDSLLAVARPFFAKNREVLTHDVN FT NLATVTTTLLQPDPLDGLETVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFANPMEFI FT CSSIQAGSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSEPRL FT QPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLTPESLAELMG FT GPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPPPPPGPDVIPGPVPPTPAP FT VGAPLPAEAGGGQ" FT CDS 204257..205429 FT /transl_table=11 FT /gene="lprK" FT /locus_tag="Mb0179" FT /standard_name="mce1E" FT /product="POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY FT LIPOPROTEIN MCE1E)" FT /note="Mb0179, lprK, len: 390 aa. Equivalent to Rv0173, FT len: 390 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 390 aa overlap). Possible lprK FT (alternate gene name: mce1E), lipoprotein which belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), highly similar FT to Mycobacterium tuberculosis proteins FT O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); FT O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also FT highly similar to others e.g. NP_302660.1|NC_002677 FT putative lipoprotein from Mycobacterium leprae (392 aa); FT CAC12794.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (413 aa); etc. Contains PS00013 FT prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:Q7U2N5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93043.1" FT /translation="MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGP FT GTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLKKDVTLPK FT NATAKIGQTSLLGSQHVELAAPPDPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLR FT GGGLVNLEGIQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAY FT VGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQ FT ALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAF FT LTGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC" FT CDS 205423..206970 FT /transl_table=11 FT /gene="mce1F" FT /locus_tag="Mb0180" FT /product="MCE-FAMILY PROTEIN MCE1F" FT /note="Mb0180, mce1F, len: 515 aa. Equivalent to Rv0174, FT len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 515 aa overlap). mce1F; belongs to FT 24-membered Mycobacterium tuberculosis Mce protein family FT (see citations below for more information), similar to FT Mycobacterium tuberculosis proteins FT O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); FT O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly FT similar to others e.g. NP_302661.1|NC_002677 putative FT secreted protein from Mycobacterium leprae (516 aa); FT AAF74993.1|AF143400_1|AF143400|996A027a protein from FT Mycobacterium avium (80 aa) (similarity on C-terminus); FT CAC12793.1|AL445327 putative secreted protein from FT Streptomyces coelicolor (433 aa); etc. Has hydrophobic FT stretch, possibly a signal peptide at the N-terminus." FT /db_xref="InterPro:IPR005693" FT /db_xref="UniProtKB/TrEMBL:Q7U2N4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93044.1" FT /translation="MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKAD FT LPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVHSVSAV FT GEQYIDLVSTGAPGKYFSSGQTITKGTVPSEIGPALDNSNRGLAALPTEKIGLLLDETA FT QAVGGLGPALQRLVDSTQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKL FT NNLAAQTATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAG FT VEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSPADTSPR FT PLPSGTYCKIPQDAQLQVRGARNIPCVDVPGKRAATPKECRSKDPYVPLGTNPWFGDPN FT QILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQ FT CNGQQPNPCVYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS" FT CDS 207006..207647 FT /transl_table=11 FT /gene="Mb0181" FT /locus_tag="Mb0181" FT /product="PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE FT PROTEIN" FT /note="Mb0181, -, len: 213 aa. Equivalent to Rv0175, len: FT 213 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 213 aa overlap). Probable conserved FT Mce-associated membrane protein, equivalent, but longer in FT N-terminus, to CAC32127.1|AL583926 possible membrane FT protein from Mycobacterium leprae (182 aa). Also similar to FT mce-associated proteins from Mycobacterium tuberculosis FT e.g. Rv1363c, Rv0177, Rv1973, etc. Contains two 12 residue FT direct repeats at N-terminus." FT /db_xref="UniProtKB/TrEMBL:Q7U2N3" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93045.1" FT /translation="MKAADSAESDAGADQTGPQVKAADSAESDAGELGEDACPEQALVE FT RRPSRLRRGWLVGIAATLLALAGGLGAAGYFALRSHQESQSIAREDLAAIEAAKDCVAA FT TQAPDAGAMSASMQKIIECGTGDFGAQASLYTSMLVEAYQAASVHVQVTDMRAAVERNN FT NDGSVDVLVALRVKVSNTDSDAHEVGYRLRVRMALDEGRYKIAKLDQVTK" FT CDS 207644..208612 FT /transl_table=11 FT /gene="Mb0182" FT /locus_tag="Mb0182" FT /product="PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE FT PROTEIN" FT /note="Mb0182, -, len: 322 aa. Equivalent to Rv0176, len: FT 322 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.4% identity in 322 aa overlap). Probable conserved FT Mce-associated transmembrane protein. Contains short region FT of similarity to PRA_MYCLE|P41484 proline-rich antigen (36 FT kDa antigen) from Mycobacterium leprae (249 aa) (outside FT the proline-rich region), FASTA scores: opt: 165, E(): FT 2.9e-05, (40.0% identity in 65 aa overlap). Also similar to FT mce-associated proteins from Mycobacterium tuberculosis FT e.g. Rv1363c, Rv0177, Rv3493c, etc." FT /db_xref="GOA:Q7U2N2" FT /db_xref="InterPro:IPR010432" FT /db_xref="UniProtKB/TrEMBL:Q7U2N2" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93046.1" FT /translation="MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATMA FT LTALTVPPGSAWRWLCACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGSAI FT GPWRLLVRDLAHLVDTLSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVIRRL FT TAAVALAAAGACASATAVGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPETVQRD FT FERARSLATDRYRPQLSIQQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFMQGERG FT TPPNQRYISATVRAIFQKSRGQWRLDDLAVVMKPRQPTGEK" FT CDS 208609..209163 FT /transl_table=11 FT /gene="Mb0183" FT /locus_tag="Mb0183" FT /product="PROBABLE CONSERVED MCE ASSOCIATED PROTEIN" FT /note="Mb0183, -, len: 184 aa. Equivalent to Rv0177, len: FT 184 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 184 aa overlap). Probable conserved FT Mce-associated protein, equivalent to CAC32129.1|AL583926 FT conserved membrane protein from Mycobacterium leprae (184 FT aa). Also similar to mce-associated proteins from FT Mycobacterium tuberculosis e.g. Rv1363c, Rv1973, Rv3493c, FT etc." FT /db_xref="UniProtKB/TrEMBL:Q7U2N1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93047.1" FT /translation="MSPRRKFEPGEGALLAPQSIEPSRRWGLPLALTASAVVMAAAISA FT CALMRISHESHQRAAHKDIVMLSDVRSFMTMFTSPDPFHANEYAERVLSHATGDFAKQY FT HERANDILIRISGVEPTTGTVLDAGVQRWNEDGSANVLVVTQITSKSADGKRVVSNANR FT WLVTAKQEGNEWKISSLLPVI" FT CDS 209130..209864 FT /transl_table=11 FT /gene="Mb0184" FT /locus_tag="Mb0184" FT /product="PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE FT PROTEIN" FT /note="Mb0184, -, len: 244 aa. Equivalent to Rv0178, len: FT 244 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 244 aa overlap). Probable conserved FT Mce-associated membrane protein, highly similar in FT C-terminus to CAC32130.1|AL583926 putative secreted protein FT from Mycobacterium leprae (184 aa). Also similar to FT mce-associated proteins from Mycobacterium tuberculosis FT e.g. Rv1363c, Rv0177, Rv1973, etc. Note that there is a 10 FT aa overlap with the upstream ORF." FT /db_xref="UniProtKB/TrEMBL:Q7U2N0" FT /protein_id="CAD93048.1" FT /translation="MEDQQSASGDLTQKSVANGESTDTASAATEGHRGEIDAAGEPDER FT GAAVADSQADEDDSAATAARGGKTRARRSRGRRLAITVGVAAALFVGSAAFAGATVEPY FT LSERAVVATKLMVARTAANAITTLWTYTPENMDTLADRAANYLSGDFAAQYRRFVDQIA FT AANKQAKITNDTEVTGAAVESLSGRDAVAIVYTNTTTTSPVTKNIPALKYLSYRLFMKR FT YDARWLVTRMTTITSLDLTPQV" FT CDS complement(209895..211004) FT /transl_table=11 FT /gene="lprO" FT /locus_tag="Mb0185c" FT /product="PUTATIVE LIPOPROTEIN LPRO" FT /note="Mb0185c, lprO, len: 369 aa. Equivalent to Rv0179c, FT len: 369 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 369 aa overlap). Possible lprO, FT lipoprotein (visibly not conserved). Contains possible FT N-terminal signal sequence and PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="UniProtKB/TrEMBL:Q7U2M9" FT /protein_id="CAD93049.1" FT /translation="MWIRAERVAVLTPTASLRRLTACYAALAVCAALACTTGQPAARAA FT DGREMLAQAIATTRGSYLVYNFGGGHPMPLLNAGGHWYEMNNGGHLMIIKNASQRLSPH FT LLVDTHTGDQARCEHNPGAHTGEGLWQASEIYPPLKAWQRMGRPTIAVNANFFDVRGQK FT GGSWRSTGCSSPLGAYVDNTRGQGRANQAVTGTVAYAGKQGLSGGNELWSSLTTMILPV FT GGAPYVLRPKSRQDYDLATPVIEDLLNKNARFVAVAGIGLLSPGNTGQLHDGGPSAART FT ALAYAKQKDEMYIFQGGNYTPDNIQDLFRGLGSDTAILLDGGGSSAIVLRRDTGGMWAG FT AGSPKGSCDTRQVLCDSHERALPSWLAFN" FT CDS complement(211084..212442) FT /transl_table=11 FT /gene="Mb0186c" FT /locus_tag="MbXXXXc" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="MbXXXXc -, len: 452 aa. Equivalent to Rv0180c, len: FT 452 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 452 aa overlap). Probable conserved FT transmembrane protein, equivalent to CAC32132.1|AL583926 FT probable conserved membrane protein from Mycobacterium FT leprae (465 aa). Shows some similarity with others membrane FT proteins e.g. AL096849|SCI11_29 from Streptomyces FT coelicolor (354 aa), FASTA scores: opt: 190, E(): 0.00067, FT (25.9% identity in 409 aa overlap)." FT /db_xref="GOA:Q7U2M8" FT /db_xref="UniProtKB/TrEMBL:Q7U2M8" FT /protein_id="CAD93050.1" FT /translation="MSQAQPRPAAPNPKRNVKAIRTVRFWMAPIATTLALMSALAALYL FT GGILNPMTNLRHFPIALVNEDAGPAGQQIVDGLVSGLDKNKFDIRVVSPDEARRLLDTA FT AVYGSALIPPTFSSQLRDFGASAVTPTRTDRPAITISTNPRAGTLAASIAGQTLTRALT FT VVNGKVGERLTAEVAAQTGGVALAGAAAAGLASPIDVKSTAYNPLPNGTGNGLSAFYYA FT LLLLLAGFTGSIVVSTLVDSMLGYVPAEFGPVYRFAEQVNISRFRTLLVKWAVMVVLAL FT LTSGVYLAIAHGLGMPIPLGWQVWLYGVFAIIAVGVTSSSLIAVLGSMGLLVSMLIFVI FT LGLPSAGATVPLEAVPAFFRWLAQFEPMHQVFLGVRSLLYLNGNADAGLSQALTMTSIG FT LIIGLLLGGFITHLYDRSSFHRIPGAVEMAIAVEHQAQYQARQSARESSSEQP" FT CDS complement(212469..213203) FT /transl_table=11 FT /gene="Mb0187c" FT /locus_tag="Mb0187c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0187c, -, len: 244 aa. Equivalent to Rv0181c, len: FT 244 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 244 aa overlap). Conserved hypothetical FT protein, highly similar to other hypothetical proteins e.g. FT YHHW_ECOLI|P46852 hypothetical 26.3 kd protein from FT Escherichia coli (231 aa), FASTA scores: opt: 479, E(): FT 1.2e-29, (37.3% identity in 233 aa overlap); P73623|SLL1773 FT HYPOTHETICAL 25.7 KD PROTEIN from Synechocystis sp. strain FT PCC 6803 (232 aa), FASTA score: (39.1% identity in 233 aa FT overlap)." FT /db_xref="InterPro:IPR003829" FT /db_xref="UniProtKB/Swiss-Prot:P65725" FT /protein_id="CAD93051.1" FT /translation="MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLV FT NNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGILH FT SEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAALTL FT HNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGL FT TANEPSEVLIWEMHAKLGDSAT" FT CDS complement(213220..214332) FT /transl_table=11 FT /gene="sigG" FT /locus_tag="Mb0188c" FT /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR FT SIGG (RNA POLYMERASE ECF TYPE SIGMA FACTOR)" FT /note="Mb0188c, sigG, len: 370 aa. Equivalent to Rv0182c, FT len: 370 aa (start site uncertain; first of several FT possibles was chosen, but note that this overlaps the FT upstream ORF), from Mycobacterium tuberculosis strain FT H37Rv, (100.0% identity in 370 aa overlap). Probable sigG, FT alternative RNA polymerase sigma subunit (see citations FT below), similar to many e.g. Q45585|SIGW_BACSU RNA FT POLYMERASE SIGMA FACTOR from Bacillus subtilis (187 aa). FT Also similar to nine other ECF sigma factors from FT Mycobacterium tuberculosis e.g. Rv1221, Rv0735, etc. FT Contains PS01063 Sigma-70 factors ECF subfamily signature FT and probable helix-turn helix motif from aa 205-226 (Score FT 1181, +3.21 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF FT SUBFAMILY." FT /db_xref="GOA:Q7U2M7" FT /db_xref="HSSP:1H3L" FT /db_xref="InterPro:IPR013249" FT /db_xref="UniProtKB/TrEMBL:Q7U2M7" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93052.1" FT /translation="MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAEN FT SGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFAGK FT SSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPDVTD FT DPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTSTVAVN FT SLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTAEAIWE FT MPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVHLPFQLH FT VLDMAADRVSHVVAFLDTTLFPKFGLPDSL" FT CDS 214280..215119 FT /transl_table=11 FT /gene="Mb0189" FT /locus_tag="Mb0189" FT /product="POSSIBLE LYSOPHOSPHOLIPASE" FT /EC_number="3.1.-.-" FT /note="Mb0189, -, len: 279 aa. Equivalent to Rv0183, len: FT 279 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 279 aa overlap). Possible FT lysophospholipase (EC 3.1.-.-), similar to several FT (especially eukaryotic enzymes, weaker with Escherichia FT coli), e.g. U67963|HSU67963_1 Human lysophospholipase FT homolog from Homo sapiens (313 aa), FASTA scores: opt: 569, FT E(): 2.6e-29, (37.1% identity in 259 aa overlap); FT P07000|PLDB_ECOLI LYSOPHOSPHOLIPASE L2 from Escherichia FT coli (165 aa), FASTA scores: opt: 219, E(): 0.00012. Start FT changed based on similarity to AE001997_8 from Deinococcus FT radiodurans (282 aa), FASTA scores: opt: 510, E(): 1.4e-25, FT (34.8% identity in 282 aa overlap). Also shows some FT similarity to epoxide hydrolases from Mycobacterium FT tuberculosis e.g. Rv1938 FASTA score: (30.7% identity in FT 114 aa overlap); and FT O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa). Note FT that the putative product of this CDS corresponds to spot FT 3_329 identified in culture supernatant by proteomics at FT the Max-Planck-Institut fuer Infektionsbiologie (see FT citations below)." FT /db_xref="GOA:Q7U2M6" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q7U2M6" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93053.1" FT /translation="MTTTRTERNFAGIGDVRIVYDVWTPDTAPQAVVVLAHGLGEHARR FT YDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRDISEYTADFDTLVGIATREYPGCKR FT IVLGHSMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPGLPV FT QELDFTAISRDPEVVQAYNTDPLVHHGRVPAGIGRALLQVGETMPRRAPALTAPLLVLH FT GTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVFNEPERNQVLDDVVAWLTERL" FT CDS 215161..215910 FT /transl_table=11 FT /gene="Mb0190" FT /locus_tag="Mb0190" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0190, -, len: 249 aa. Equivalent to Rv0184, len: FT 249 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 249 aa overlap). Conserved hypothetical FT protein, equivalent to CAC32136.1|AL583926 conserved FT hypothetical protein from Mycobacterium lepra (249 aa); and FT C-terminus highly similar to CAB08793.1|Z95398 conserved FT hypothetical protein from Mycobacterium leprae (145 aa), FT FASTA scores: E(): 0, (75.2 identity in 145 aa overlap). FT Also similar to 049841|SCE9_39|T36358 hypothetical protein FT from Streptomyces coelicolor (418 aa), FASTA scores: opt: FT 231, E(): 8.1e-08, (30.4% identity in 270 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2M5" FT /protein_id="CAD93054.1" FT /translation="MTNDKMLARIAALLRQAEGTDNPHEADAFMSTAQRLATAASIDLA FT VARSHAGNRSPAQAPTQRTITIGAAGTRGLRTYVQLFVLIAAANDVRCDVASNSTFVYA FT YGFAEDIDTSHALYASLVVQMVRASDAYLASGAHRPTPTITARLNFQLAFGARVGQRLA FT DAREQTRQEATKDRDRPPGTAIALRDKDIELHEYYRRSSKARGAWRASRATAGYSSAAR FT RAGDRAGRQARLGNNPELPGARAALGR" FT CDS 215907..216416 FT /transl_table=11 FT /gene="Mb0191" FT /locus_tag="Mb0191" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0191, -, len: 169 aa. Equivalent to Rv0185, len: FT 169 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 169 aa overlap). Conserved hypothetical FT protein, equivalent to CAB08794.1|Z95398|MLCL622_2 from FT Mycobacterium leprae (168 aa), FASTA scores: opt: 861, E(): FT 0, (76.4% identity in 165 aa overlap). Contains PS00142 FT Neutral zinc metallopeptidases, zinc-binding region FT signature." FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:Q7U2M4" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93055.1" FT /translation="MIGADVPRDSQRARVYAAEAFVRTLFDRVTAHGSPTVEFFGTQLT FT LPPEGRFGSVASVQRYVDDVLALPAVGQNWPTVSPVRVRARRAATAAHYENHGGTGTIA FT VPDRHTAGWAMRELVVLHEVAHHLCQVPPPHGPEFVATVCTLTELVMGPEVGHVFRVVY FT AQEGVR" FT CDS 216461..218536 FT /transl_table=11 FT /gene="bglS" FT /locus_tag="Mb0192" FT /product="PROBABLE BETA-GLUCOSIDASE BGLS (GENTIOBIASE) FT (CELLOBIASE) (BETA-D-GLUCOSIDE GLUCOHYDROLASE)" FT /EC_number="3.2.1.21" FT /note="Mb0192, bglS, len: 691 aa. Equivalent to Rv0186, FT len: 691 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 691 aa overlap). Probable bglS, FT beta-glucosidase (EC 3.2.1.21), highly similar to many e.g. FT BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium FT tumefaciens (818 aa), FASTA scores: opt: 643, E(): 0, FT (32.5% identity in 842 aa overlap). SEEMS TO BELONG TO FT FAMILY 3 OF GLYCOSYL HYDROLASES." FT /db_xref="GOA:Q7U2M3" FT /db_xref="InterPro:IPR002772" FT /db_xref="UniProtKB/TrEMBL:Q7U2M3" FT /protein_id="CAD93056.1" FT /translation="MTDDERFSLLVGLTGASDLWPVRDERIPQGVPMCAGYVPGIPRLG FT VPALLMSDAGLGVTNPGYRPGDTATALPAGLALAASFNPVLARSSGKAIGREARSRGFN FT VQLAGAINLARDPRNGRNFEYLSEDPLLSATMAAESIIGIQQQGVIATTKHFSLNCNET FT NRHWLDAVIDPDAHRESDLLAFEIVIERSQPGAVMAAYNKVNGDYAAGNDHLLNDVLKG FT AWGYRGWVMSDWGGTPSWECALAGLDQECGAQIDAVLWQSEAFTDRLRAAYADGNLPKG FT RLSDMVRRILRSMFAVGIDRWKPAPAPDMNAHNEIAAQMARQGIVLLQNRGLLPLAPES FT AGRIAVIGGYAHLGVPAGYGSSAVTPPGGYAGVIPIGGSGLAAGLRNLYLLPSSPLSEL FT RKRLPNAQFEFDPGINPAEAVLAARRADIAIVFAIRAEGEGFDSADLSLPWGQDALIAA FT VASANANTVVVLETGNPVTMPWRDSVNAIMQAWYPGQAGGQAVAEIVTGQVNPSGRLPI FT TFPVDLGQTPRSQPRELGAPWGTSTTIHYTEGADVGYRWFASTNQTPMFAFGHGLSYTS FT FEYRDLVVTGGHTVHASFSVTNTGDRSGADVPQLYMIAAPGESRLRLLGFERVELEPGQ FT TRRVRIEADPRLLARYDGEARSWRIEPGGYTVAVGASAVALKLAAKVKLAGRGFGR" FT CDS 218897..219559 FT /transl_table=11 FT /gene="Mb0193" FT /locus_tag="Mb0193" FT /product="PROBABLE O-METHYLTRANSFERASE" FT /EC_number="2.1.1.-" FT /note="Mb0193, -, len: 220 aa. Equivalent to Rv0187, len: FT 220 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 220 aa overlap). Probable FT O-methyltransferase (EC 2.1.1.-), similar to many e.g. FT AB93458.1|AL357591 putative O-methyltransferase from FT Streptomyces coelicolor (223 aa); MDMC_STRMY|Q00719 FT O-methyltransferase from Streptomyces mycarofaciens (221 FT aa), FASTA scores: opt: 327, E(): 2.4e-17, (35.9% identity FT in 192 aa overlap). Also similar to Rv1703c, Rv1220c from FT Mycobacterium tuberculosis." FT /db_xref="GOA:Q7U2M2" FT /db_xref="InterPro:IPR002935" FT /db_xref="UniProtKB/TrEMBL:Q7U2M2" FT /protein_id="CAD93057.1" FT /translation="MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVS FT AQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVARVN FT LQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVAYIQWAIRLARRGAVIV FT VDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR" FT CDS 219678..220109 FT /transl_table=11 FT /gene="Mb0194" FT /locus_tag="Mb0194" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0194, -, len: 143 aa. Equivalent to Rv0188, len: FT 143 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 143 aa overlap). Probable conserved FT transmembrane protein, similar to FT T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable FT membrane protein from Streptomyces coelicolor (147 aa), FT FASTA scores: opt: 326, E(): 6.5e-15, (36.2% identity in FT 141 aa overlap); N-terminus of P80185|MTRC_METTH FT TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT C (EC FT 2.1.1.86) from Methanobacterium thermoautotrophicum strain FT Marburg/DSM 2133 (266 aa), FASTA scores: opt: 125, E(): FT 0.033, (31.6% identity in 98 aa overlap). Also similar to FT Rv3635 from Mycobacterium tuberculosis." FT /db_xref="GOA:Q7U2M1" FT /db_xref="InterPro:IPR005530" FT /db_xref="UniProtKB/TrEMBL:Q7U2M1" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93058.1" FT /translation="MSTVHSSIDQHPDLLALRASFDRAAESTIAHFTFGLALLAGLYVA FT ASPWIVGFSATRGLPTCDLIVGIAVAYLAYGFASALDRTHGMTWTLPVLGVWVIFSPWV FT LPGVAVTAGMMWSHIIAGAVVAVLGFYFGMRTRAAANQG" FT CDS complement(220188..221915) FT /transl_table=11 FT /gene="ilvD" FT /locus_tag="Mb0195c" FT /product="PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD)" FT /EC_number="4.2.1.9" FT /note="Mb0195c, ilvD, len: 575 aa. Equivalent to Rv0189c, FT len: 575 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 575 aa overlap). Probable ilvD, FT dihydroxy-acid dehydratase (EC 4.2.1.9), similar to many FT e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) FT from Lactococcus lactis (subsp. lactis) (Streptococcus FT lactis) (570 aa), FASTA scores: opt: 1605, E(): 0, (46.0% FT identity in 561 aa overlap). Also similar to FT ML2608|MLCL622.06c|O06069|ILVD_MYCLE DIHYDROXY-ACID FT DEHYDRATASE from Mycobacterium leprae (564 aa). Contains FT PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases FT signature 1. BELONGS TO THE ILVD / EDD FAMILY. COFACTOR: FT BINDS 1 4FE-4S CLUSTER (POTENTIAL)." FT /db_xref="GOA:P65155" FT /db_xref="InterPro:IPR000581" FT /db_xref="UniProtKB/Swiss-Prot:P65155" FT /protein_id="CAD93059.1" FT /translation="MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARGMLRAVGMDDE FT DFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGYPLEFGTISVSDGISMGHEG FT MHFSLVSREVIADSVEVVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLAAVFLYAGSI FT LPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPGEGACGGMYTANT FT MASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAI FT AVVMAFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMSDVDHI FT GGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVLRALANPIHPSGGIT FT ILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAALDALEDGTITVGDAVVIRYEGPK FT GGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHIAPEAVDGGPIALLRN FT GDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG" FT CDS 222063..222353 FT /transl_table=11 FT /gene="Mb0196" FT /locus_tag="Mb0196" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0196, -, len: 96 aa. Equivalent to Rv0190, len: 96 FT aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% FT identity in 96 aa overlap). Conserved hypothetical protein, FT highly similar to several hypothetical proteins e.g. FT SYCSLRA_35|Q55554|SLL0176 hypothetical 18.9 KD protein from FT Synechocystis (167 aa), FASTA scores: opt: 237, E(): FT 5.8e-16, (39.4% identity in 94 aa overlap). Also highly FT similar to Z95398|MLCL622_7|O06070 from Mycobacterium FT leprae (135 aa), FASTA score: (82.6% identity in 92 aa FT overlap). Also similar to hypothetical proteins from FT Mycobacterium tuberculosis e.g. Rv0967, Rv0030, Rv1766 FT (42.5% identity in 80 aa overlap)." FT /db_xref="InterPro:IPR003735" FT /db_xref="UniProtKB/TrEMBL:Q7U2M0" FT /protein_id="CAD93060.1" FT /translation="MTAAHGYTQQKDNYAKRLRRVEGQVRGIARMIEEDKYCIDVLTQI FT SAVTSALRSVALNLLDEHLSHCVTRAVAEGGPGADGKLAEASAAIARLVRS" FT CDS 222481..223722 FT /transl_table=11 FT /gene="Mb0197" FT /locus_tag="Mb0197" FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" FT /note="Mb0197, -, len: 413 aa. Equivalent to Rv0191, len: FT 413 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 413 aa overlap). Probable conserved FT integral membrane protein, member of major facilitator FT superfamily (MFS) possibly involved in transport of drug, FT similar to several hypothetical proteins e.g. FT YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from FT Escherichia coli (396 aa), FASTA scores: opt: 475, E(): FT 4.2e-33, (29.7% identity in 381 aa overlap); and to several FT chloramphenicol resistance proteins e.g. CMLR_STRLI|P31141 FT chloramphenicol resistance protein from stremtomyces FT lividans (392 aa), FASTA scores: opt: 394, E(): 6.7e-12, FT (28.2% identity in 383 aa overlap). Also similar to FT SVU09991_1 from Mycobacterium tuberculosis." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q7U2L9" FT /protein_id="CAD93061.1" FT /translation="MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGALS FT AIARNLRVSVVLVGTLLSWYALVAAVTTVPLVRWTAHWPRRRALVVSLVCLTVSQLVSA FT LAPNFAVLAAGRVLCAVTHGLLWAVIAPIATRLVPPSHAGRATTSIYIGTSLALVVGSP FT LTAAMSLMWGWRLAAVCVTGAAAAVALAARLALPEMVLRADQLEHVGRRARHHRNPRLV FT KVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLLAAYGVAGLVSVPLVARPLDR FT WPKGAVIVGMTGLTAAFTLLTALAFGERHTAATALLGTGAIVLWGALATAVSPMLQSAA FT MRSGGDDPDGASGLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVALFGMTVS FT QHLFENPTLSPGDG" FT CDS 223799..224857 FT /transl_table=11 FT /gene="Mb0198" FT /locus_tag="Mb0198" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0198, -, len: 352 aa. Equivalent to Rv0192 and FT Rv0192A, len: 366 aa and 100 aa, from Mycobacterium FT tuberculosis strain H37Rv, (96.5% identity in 318 aa FT overlap and 91.1% identity in 56 aa overlap). Conserved FT hypothetical protein. Has Gly- Arg-rich region followed by FT highly Pro-rich repetitive region near N-terminus. Similar FT in C-terminus to other hypothetical proteins e.g. FT Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 FT aa), FASTA scores: opt: 375, E(): 3.2e-24, (36.1% identity FT in 255 aa overlap); YV09_MYCTU|Q11149|cY20G9.09 FT hypothetical 47.9 kd protein from Mycobacterium FT tuberculosis (451 aa), FASTA scores: opt: 330, E(): FT 3.2e-13, (35.1% identity in 271 aa overlap). Also similar FT to Rv0116c, Rv1433, Rv2518c, Rv0483 from Mycobacterium FT tuberculosis. Probable N-terminal part of Rv0192, which is FT member of family P5.17 with Rv0116c, Rv1433, Rv2518c, FT Rv0483. These are all predicted to be exported/membrane FT proteins. Rv0192A has typical N-terminal signal peptide FT which is functional and was identified by PhoA fusion FT screens: O52054 PGB14T-O1 PRECURSOR (FRAGMENT 45 AA) (see FT citation below). Since Rv0192 misses a signal peptide this FT suggests that there is a frameshift in the region of the FT overlap with Rv0192 but none found on reinspection of FT sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 FT genes with an overlap region. In Mycobacterium bovis, a FT single base insertion (*-g) leads to a single product." FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:Q7U2L8" FT /protein_id="CAD93062.1" FT /translation="MSRWKQGWTRGSLFAALNIAAVVAVLMLGAGVAVADPDAAPGDPG FT GPGGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVAAG FT PVAGQDPTPFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHISSIP FT PVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQMTIT FT RNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYKLTVSD FT AVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVVKNSVGT FT YNKNDGAQDWQI" FT CDS complement(224917..226764) FT /transl_table=11 FT /gene="Mb0199c" FT /locus_tag="Mb0199c" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0199c, -, len: 615 aa. Equivalent to Rv0193c, len: FT 615 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 615 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2L7" FT /protein_id="CAD93063.1" FT /translation="MIQISRDMSSLGQTATTQALPDNSDGIQLTKFAADDILPLEYAPP FT IGPELVSQDQLPAAWAYKRFRDLDDKESYRRKLLQELTDALAAQGSEAAEIATAALRDL FT IDQMAEQGAVVLADIVESDDFLELVKRYDELMAREGSRSFIHRFLDLRRSPGMLTDPAV FT NGALVHPLMIALISYAVGGPIRMIDARGKDAEPLSVLAQDNMLHIDNTPFNDEYKILIT FT WRRGTAQGPAGQNFTFLPGTHKLARTCFVNEDGVPWSSENASIFTTPDSIRKVFDAQRQ FT LGGQDHPTVIEVTDSERPLSSVFAAGSLVHHRFRTASGSARSCIILVFHRVADNPGRMV FT SDVEDSSDVSLSELLTRGVPDESYQQRFIATLCAAADEIAELLLKWKKTPQRPVSLPLQ FT TKQIDGARFEEWISAATEAPEVREIRNRELTIPYGEVLSAEEFFDLIWRLMRFDKHGPL FT DLILYHDNREEPRKWARNLIREMSADRLYERLLGWLADIQQPRPADCLRPLQIHALISE FT VLKTLPLDEDQDPPADWHFDLLGMSHAEAARSVKHLLEDVAEALLRCEDMAAYLSTSLF FT AFWAVDAAYSLDGRRNLVVKDCARRLLRHYTMLSLTCFQ" FT CDS 227071..230655 FT /transl_table=11 FT /gene="Mb0200" FT /locus_tag="Mb0200" FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE FT ATP-BINDING PROTEIN ABC TRANSPORTER" FT /note="Mb0200, -, len: 1194 aa. Equivalent to Rv0194, len: FT 1194 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 1194 aa overlap). Probable FT drugs-transport transmembrane protein ATP binding protein FT ABC transporter (see citation below), highly similar to FT many e.g. U62129|STU62129_2|T30293 ABC transport protein FT homolog from Salmonella typhi (1218 aa), FASTA scores: opt: FT 1116, E(): 0, (36.3% identity in 1209 aa overlap); FT CAB66302.1|AL136519 ABC transporter protein ATP-binding FT component from Streptomyces coelicolor (1243 aa); I84547 FT mdl protein from Escherichia coli (1143 aa); etc. Also FT similar to MTCY50_9 and MTCY50_10 from Mycobacterium FT tuberculosis, FASTA score: (33.8% identity in 574 aa FT overlap). Contains two PS00017 ATP/GTP-binding site motif A FT (P-loop) and one PS00211 ABC transporters family signature. FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC FT TRANSPORTERS). Alternative start possible at 1823 but no FT RBS." FT /db_xref="GOA:Q7U2L6" FT /db_xref="HSSP:1JJ7" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q7U2L6" FT /protein_id="CAD93064.1" FT /translation="MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVI FT DDAVAADHRPLAPWAVVLVAAAGATYLLTYVRRYYGGRIAHLVQHDLRMDAFQALLRWD FT GRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAVMTWLSVPLALLAV FT LLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLV FT MASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFVAFWAC FT LTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSLEARLSLEFQRVS FT FGYVADRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVR FT ELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIEEFVNTLPD FT GYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECGIQEVLREAI FT ADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERCPRYRELLSPAPDLADDL FT VVAERSPVCRPVAGLGTKAAQHTNVHNPGPHDHPPGPDPLRRLLREFRGPLALSLLLVA FT VQTCAGLLPPLLIRHGIDVGIRRHVLSALWWAALAGTATVVIRWVVQWGSAMVAGYTGE FT QVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLRTGLVVAVISVVTL FT VGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARHRLGTVTATLREYAA FT GLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVALLCSLATTLVLLDGA FT REVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVAAGRIRSLLSTRTPSSP FT AARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTVVFVGSTGSGKSTLIKLV FT ARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGTVRDAIAYGRPDATDAQ FT VERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALARARLVDPDILLLDEAT FT VALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEHGTVVEDGAHTELLA FT AGGHYSRLWAAHTRLCSPEITQLQCIDA" FT CDS 231093..231728 FT /transl_table=11 FT /gene="Mb0201" FT /locus_tag="Mb0201" FT /product="PUTATIVE TWO COMPONENT TRANSCRIPTIONAL REGULATORY FT PROTEIN (PROBABLY LUXR-FAMILY)" FT /note="Mb0201, -, len: 211 aa. Equivalent to Rv0195, len: FT 211 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 211 aa overlap). Putative two-component FT response regulator, luxR family, similar to many e.g. FT U00008|ECOHU49_15 regulatory protein narP from Escherichia FT coli strain K12 (225 aa), FASTA scores: opt: 232, E(): FT 7.3e-09, (29.2% identity in 219 aa overlap). Start chosen FT by similarity. Contains probable helix-turn-helix motif at FT aa 166-187 (Score 1164, +3.15 SD)." FT /db_xref="GOA:Q7U2L5" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:Q7U2L5" FT /protein_id="CAD93065.1" FT /translation="MAPVNVISVAVVASDPLTRDGALARLSSHRELDVRAWQAGCETSV FT LLVLATTITAPLLCQIEDVQKDGPSHAPKLVVVADEFSAEQVFRMIKLGLTGLLYRSQS FT TFDCIVETIRLSAEGRLRLPERVQRYLVGRIKSTPTAEPDTPCAAALAEREVAVLRLLA FT DGLSTHQVAVQLNYCERTIKNIVHDIVTRLKLRNRTHAVAHALRAGLI" FT CDS 231841..232425 FT /transl_table=11 FT /gene="Mb0202" FT /locus_tag="Mb0202" FT /product="PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN" FT /note="Mb0202, -, len: 194 aa. Equivalent to Rv0196, len: FT 194 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 194 aa overlap). Putative FT transcriptional regulatory protein, similar to two Bacillus FT subtilis regulators: P42105|YXAF_BACSU HYPOTHETICAL 21.0 KD FT PROTEIN (191 aa), FASTA scores: opt: 323, E(): 2.1e-15, FT (30.9% identity in 181 aa overlap); and Z99105|BSUB0002_9 FT negative regulator of the lincomycin operon (188 aa), FASTA FT scores: opt: 255, E(): 1e-10, (25.9 identity in 185 aa FT overlap)." FT /db_xref="GOA:Q7U2L4" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q7U2L4" FT /protein_id="CAD93066.1" FT /translation="MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYFP FT GGRTQLLCEAVDYAGEHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAVSV FT EAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEGAIL FT LARVRRDLTPLDLVHRQLRNLLLAELPERSR" FT CDS 232425..234671 FT /transl_table=11 FT /gene="Mb0203" FT /locus_tag="Mb0203" FT /product="POSSIBLE OXIDOREDUCTASE" FT /EC_number="1.-.-.-" FT /note="Mb0203, -, len: 748 aa. Equivalent to Rv0197, len: FT 762 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.9% identity in 748 aa overlap). Possible oxidoreductase FT (EC 1.-.-.-), similar to others e.g. FT 9948789|AAG06102.1|AE004699_7|B83307 probable molybdopterin FT oxidoreductase from Pseudomonas aeruginosa strain PAO1 (769 FT aa); 5441785|CAB46809.1|AL096811|T36812 probable FT dehydrogenase from Streptomyces coelicolor (747 aa), FASTA FT scores: opt: 617, E(): 9.8e-30, (29.9% identity in 762 aa FT overlap); BAB04334.1|AP001509 assimilatory nitrate FT reductase (catalytic subunit) from Bacillus halodurans (743 FT aa); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium FT bovis, a single base transversion (t-g) introduces a stop FT codon that leads to a shorter product compared to its FT homolog in Mycobacterium tuberculosis strain H37Rv (748 aa FT versus 762 aa)." FT /db_xref="GOA:Q7U2L3" FT /db_xref="InterPro:IPR006657" FT /db_xref="UniProtKB/TrEMBL:Q7U2L3" FT /protein_id="CAD93067.1" FT /translation="MTSSDWLPTACILCECNCGIVVQVDDRRLARIRGDKAHPGSAGYT FT CNKALRLDHYQNNRARLSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKIFY FT YGGGGQGNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGGHTRGEFENAEV FT SVFVGKNPWMSQSFPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQPGCDAW FT CLAALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQRCGVDEELLRAAARR FT IGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILTGNFAKKGGQHLHSSFAPLFSQVSG FT RTPVTGAPIIAGLIPGNVVPEEILTEHPDRFRAMIVESGNPAHSLADSAACRAAFQALE FT LMVVVDVAMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFPPLPGTLPE FT PEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVAKLTAYVLYETL FT GPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNALFDAILERPSGVTFTVHNYE FT DDFALISHPDHKIALEIPEMLAEIRSLTQTPSRLTTPQLPIVLSVGERRAYTANDIFRD FT PSWRKRDANGALRVSVEDAQALGLADGCLARITTAAGSAEATVEVTETMLAGHAALPNG FT FGLDYTGDDGRTVVAGVAPNALTSTRWRDPYAGTPWHKHVPAAIRRADAESPIW" FT CDS complement(234712..236703) FT /transl_table=11 FT /gene="Mb0204c" FT /locus_tag="Mb0204c" FT /product="PROBABLE ZINC METALLOPROTEASE" FT /EC_number="3.4.24.-" FT /note="Mb0204c, -, len: 663 aa. Equivalent to Rv0198c, len: FT 663 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 663 aa overlap). Probable zinc FT metalloprotease (EC 3.4.24.-), equivalent to FT Z95398|MLCL622.12c from Mycobacterium leprae (667 aa), FT FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667 aa FT overlap). Also similar to many other metalloproteases e.g. FT members of the eukaryotic neprilysin family: FT P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA FT scores: opt: 872, E(): 0, (31.1% identity in 692 aa FT overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from FT Lactococcus lactis (626 aa), FASTA scores: opt: 862, E(): FT 0, (30.0% identity in 654 aa overlap). Contains PS00142 FT Neutral zinc metallopeptidases, zinc-binding region FT signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC FT METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY." FT /db_xref="GOA:Q7U2L2" FT /db_xref="HSSP:1DMT" FT /db_xref="InterPro:IPR006025" FT /db_xref="UniProtKB/TrEMBL:Q7U2L2" FT /protein_id="CAD93068.1" FT /translation="MTLAIPSGIDLSHIDADARPQDDLFGHVNGRWLAEHEIPADRATD FT GAFRSLFDRAETQVRDLIIQASQAGAAVGTDAQRIGDLYASFLDEEAVERAGVQPLHDE FT LATIDSAADATELAAALGTLQRAGVGGGIGVYVDTDSKDSTRYLVHFTQSGIGLPDESY FT YRDEQHAAVLAAYPGHIARMFGLVYGGESRDHAKTADRIVALETKLADAHWDVVKRRDA FT DLGYNLRTFAQLQTEGAGFDWVSWVTALGSAPDAMTELVVRQPDYLVTFASLWASVNVE FT DWKCWARWRLIRARAPWLTRALVAEDFEFYGRTLTGAQQLRDRWKRGVSLVENLMGDAV FT GKLYVQRHFPPDAKSRIDTLVDNLQEAYRISISELDWMTPQTRQRALAKLNKFTAKVGY FT PIKWRDYSKLAIDRDDLYGNVQRGYAVNHDRELAKLFGPVDRDEWFMTPQTVNAYYNPG FT MNEIVFPAAILQPPFFDPQADEAANYGGIGAVIGHEIGHGFDDQGAKYDGDGNLVDWWT FT DDDRTEFAARTKALIEQYHAYTPRDLVDHPGPPHVQGAFTIGENIGDLGGLSIALLAYQ FT LSLNGNPAPVIDGLTGMQRVFFGWAQIWRTKSRAAEAIRRLAVDPHSPPEFRCNGVVRN FT VDAFYQAFDVTEDDALFLDPQRRVRIWN" FT CDS 236746..237405 FT /transl_table=11 FT /gene="Mb0205" FT /locus_tag="Mb0205" FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN" FT /note="Mb0205, -, len: 219 aa. Equivalent to Rv0199, len: FT 219 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 219 aa overlap). Probable conserved FT membrane protein, equivalent to Z95398|MLCL622.13 from FT Mycobacterium leprae (224 aa), FASTA scores: opt: 920, E(): FT 0, (67.7% identity in 220 aa overlap). Also some similarity FT to Mce-associated membrane proteins from Mycobacterium FT tuberculosis e.g. Rv0178, Rv0175, etc." FT /db_xref="UniProtKB/TrEMBL:Q7U2L1" FT /protein_id="CAD93069.1" FT /translation="MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGIA FT STLLGVLSVAAVVLGAMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDASLQ FT RLHDGTVGQLNTDFDAVVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAARPVV FT TTKLPPFATRTDSVLLVATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESIR" FT CDS 237402..238091 FT /transl_table=11 FT /gene="Mb0206" FT /locus_tag="Mb0206" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0206, -, len: 229 aa. Equivalent to Rv0200, len: FT 229 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 229 aa overlap). Possible conserved FT transmembrane protein, equivalent to Z95398|MLCL622.14 from FT Mycobacterium leprae (229 aa), FASTA scores: opt: 1147, FT E(): 0, (74.7% identity in 229 aa overlap). Also some FT similarity to Rv1973 from Mycobacterium tuberculosis (160 FT aa); and Rv1362c|Z75555|MTCY02B10_26 (220 aa), FASTA FT scores: opt: 134, E(): 0.063, (25.8% identity in 159 aa FT overlap)." FT /db_xref="GOA:Q7U2L0" FT /db_xref="UniProtKB/TrEMBL:Q7U2L0" FT /protein_id="CAD93070.1" FT /translation="MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVLL FT VVEGVAINFWLLRRDSVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRDFN FT RDSREVVHLATGMAETVASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLARRG FT VTAQAATLAAGVEAIGPSAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGWLVLD FT VTPINAR" FT CDS complement(238088..238591) FT /transl_table=11 FT /gene="Mb0207c" FT /locus_tag="Mb0207c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0207c, -, len: 167 aa. Equivalent to Rv0201c, len: FT 167 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 167 aa overlap). Conserved hypothetical FT protein, equivalent to Z95398|MLCL622.15c from FT Mycobacterium leprae (170 aa), FASTA scores: opt: 646, E(): FT 0, (63.9% identity in 158 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2K9" FT /protein_id="CAD93071.1" FT /translation="MTLAAEPHPAPPQQPTVAWSEPDVDRRVEFWPTVAIRSALESGDI FT ATWQRIAAALKRDPYGRTARQVEEVLEGIPATGIANAFWEVLDRARTHLDANERAEVAR FT QVGLLLDRSGLQRQEFASRIGVTAQDLTAYLDGIVSPSASLMIRMRRLSDRFVRAKSVR FT AADS" FT CDS complement(238588..241488) FT /transl_table=11 FT /gene="mmpL11" FT /locus_tag="Mb0208c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL11" FT /note="Mb0208c, mmpL11, len: 966 aa. Equivalent to Rv0202c, FT len: 966 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 966 aa overlap). Probable mmpL11, FT conserved transmembrane transport protein (see citation FT below), equivalent to Z95398|MLCL622.16c from Mycobacterium FT leprae (1014 aa), FASTA scores: opt: 4076, E(): 0, (72.8% FT identity in 1017 aa overlap). Member of RND superfamily, FT similar to several putative transport proteins e.g. P96687 FT from Bacillus subtilis (724 aa), FASTA scores: opt: 594, FT E(): 9.1e-29, (26.9% identity in 717 aa overlap); etc. FT BELONGS TO THE MMPL FAMILY." FT /db_xref="GOA:P65375" FT /db_xref="InterPro:IPR000731" FT /db_xref="UniProtKB/Swiss-Prot:P65375" FT /protein_id="CAD93072.1" FT /translation="MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVA FT GSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTEAP FT NPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYVIGQ FT GALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITMGLVF FT VLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLA FT VVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKR FT SALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQ FT FDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNV FT VSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQVDVGGPTALI FT KDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQ FT WGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYG FT VRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAM FT FDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAK FT LKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRL FT AVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGY FT LIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQ FT PSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR" FT CDS 241710..242120 FT /transl_table=11 FT /gene="Mb0209" FT /locus_tag="Mb0209" FT /product="POSSIBLE EXPORTED PROTEIN" FT /note="Mb0209, -, len: 136 aa. Equivalent to Rv0203, len: FT 136 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 136 aa overlap). Possible exported FT protein (has hydrophobic stretch near N-terminus). Some FT similarity to part of U02459|LDU02459_1 hypothetical FT protein from Leishmania donovani (741 aa), FASTA score: FT opt: 111, E(): 9.1, (30.0% identity in 90 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2K8" FT /protein_id="CAD93073.1" FT /translation="MKTGTATTRRRLLAVLIALALPGAAVALLAEPSATGASDPCAASE FT VARTVGSVAKSMGDYLDSHPETNQVMTAVLQQQVGPGSVASLKAHFEANPKVASDLHAL FT SQPLTDLSTRCSLPISGLQAIGLMQAVQGARR" FT CDS complement(242172..243455) FT /transl_table=11 FT /gene="Mb0210c" FT /locus_tag="Mb0210c" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0210c, -, len: 427 aa. Equivalent to Rv0204c, len: FT 412 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 412 aa overlap). Probable conserved FT transmembrane protein, equivalent, but has C-terminal FT extension, to Z95398|MLCL622.17c from Mycobacterium leprae FT (367 aa), FASTA scores: opt: 2002, E(): 0, (82.4% identity FT in 374 aa overlap). Some similarity to Rv0585c from FT Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: FT In Mycobacterium bovis, the presence of a more likely start FT codon leads to a longer product compared to its homolog in FT Mycobacterium tuberculosis strain H37Rv (427 a versus 412 FT aa)." FT /db_xref="GOA:Q7U2K7" FT /db_xref="InterPro:IPR005242" FT /db_xref="UniProtKB/TrEMBL:Q7U2K7" FT /protein_id="CAD93074.1" FT /translation="MYRDYGATCTVTLKHVSHDAPARNLRQRVGALPRTRVGAPPAEGV FT PPRGKYWWLRWAVLAIVAIVLAIEVALGWDQLAKAWVSLYRAKWWWLLAAVAAAGASMH FT SFAQIQRTLLKSAGVHVKQWRSEAAFYAANSLSTTLPGGPVLSATFLLRQQRIWGASTV FT VASWQLVMSGVLQAVGLALLGLGGAFFLGAKNNPFSLLFTLGGFVTLLLLAQAVASRPE FT LIEGIGRRVLSWANSVRGRPADAGLPKWRETLMQLESVSLGRRDLGVAFGWSLFNWIAD FT VACLGFAAYAAGDHASVGGLAVAYAAARAVGTIPLMPGGLLVVEAVLVPGLVSSGMPLP FT SAISAMLIYRLISWLLIAAIGWVVFFFMFRTESTADSDNDRDPPTDPNLRLVIQPQGTP FT CDDPVETTPQGPAPTPDLRPEGGETPPR" FT CDS 243580..244683 FT /transl_table=11 FT /gene="Mb0211" FT /locus_tag="Mb0211" FT /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" FT /note="Mb0211, -, len: 367 aa. Equivalent to Rv0205, len: FT 367 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.5% identity in 367 aa overlap). Possible conserved FT transmembrane protein, similar to hypothetical proteins FT from many bacteria e.g. AL0209|SC4H8_6 from Streptomyces FT coelicolor (402 aa), FASTA scores: opt: 436, E(): 1.7e-21, FT (27.2% identity in 349 aa overlap); Z99117|BSUB0014_221 FT from Bacillus subtilis (353 aa), FASTA scores: opt: 394, FT E(): 8.6e-19, (28.7% identity in 324 aa overlap)." FT /db_xref="GOA:Q7U2K6" FT /db_xref="InterPro:IPR002549" FT /db_xref="UniProtKB/TrEMBL:Q7U2K6" FT /protein_id="CAD93075.1" FT /translation="MSASLDDASVAPLVRKTAAWAWRFLVILAAMVALLWVLNKFEVIV FT VPVLLALMLSALLVPPVDWLDSRGLPRAVAVTLVLLSGFAVLGGILTFVVSQFIAGLPH FT LVTEVERSIDSARRWLIEGPAHLRGEQIDNAGNAAIEALRNNQAKLTSGALSTAATITE FT LVTAAVLVLFTLIFFLYGGRSIWQYVTKAFPASVRDRVRAAGRAGYASLIGYARATFLV FT ALTDAAGVGAGLAVMGVPLALPLASLVFFGAFIPLIGAVVAGFLAVVVALLAKGIGYAL FT ITVGLLIAVNQLEAHLLQPLVMGRAVSIHPLAVVLAIAAGGVLAGVVGALLAVPTAAFF FT NNAVQVLLGGNPFADVADVSSDHLTEV" FT CDS complement(244680..247514) FT /transl_table=11 FT /gene="mmpL3" FT /locus_tag="Mb0212c" FT /product="POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT FT PROTEIN MMPL3" FT /note="Mb0212c, mmpL3, len: 944 aa. Equivalent to Rv0206c, FT len: 944 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 944 aa overlap). Possible mmpL3, FT conserved transmembrane transport protein (see first FT citation below), equivalent to Z95398|MLCL622.18c from FT Mycobacterium leprae (955 aa), FASTA scores: opt: 806, E(): FT 1.8e-21, (57.2% identity in 243 aa overlap). Member of RND FT superfamily, similar to others. BELONGS TO THE MMPL FAMILY. FT TBparse score is 0.928." FT /db_xref="GOA:Q7U2K5" FT /db_xref="InterPro:IPR000731" FT /db_xref="UniProtKB/TrEMBL:Q7U2K5" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93076.1" FT /translation="MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFYD FT DGSQSVQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQDHPDQ FT VLGWAGYLRASQATGMATADKKYTFVSIPLKGDDDDTILNNYKAIAPDLQRLDGGTVKL FT AGLQPVAEALTGTIATDQRRMEVLALPLVAVVLFFVFGGVIAAGLPVMVGGLCIAGALG FT IMRFLAIFGPVHYFAQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRRTVITA FT GRTVTFSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLGILGKHV FT DALGVRTLFRVPFLANWKISAAYLNWLADRLQRTKTREEVEAGIWGKLVNRVMKRPVLF FT AAPIVIIMILLIIPVGKLSLGGISEKYLPPTNSVRQAQEEFDKLFPGYRTNPLTLVIQT FT SNHQPVTEAQIADIRSKAMAIGGFIEPDNDPANMWQERAYAVGASKDPSVRVLQNGLIN FT PADASKKLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVILLTTTIVLMFL FT AFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLTAPVIGLIIALVF FT GLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRIITAAALIVAVVAGAFVFSDLV FT MMKYLAFGLMAALLLDATVVRMFLVPSVMKLLGDDCWWAPRWARRLQTRIGLGEIHLPD FT ERKRPVSNGRPARPPVTAGLVAARAAGDPRPPHDPTHPLAESPRPARSSPASSPELTPA FT LEATAAPAAPSGASTTRMQIGSSTEPPTTRLAAAGRSVQSPASTPPPTPTPPSAPSAGQ FT TRAMPLAANRSTDAAGDPAEPTAALPIIRSDGDDSEAATEQLNARGTSDKTRQRRRGGG FT ALSAQDLLRREGRL" FT CDS complement(247580..248308) FT /transl_table=11 FT /gene="Mb0213c" FT /locus_tag="Mb0213c" FT /product="CONSERVED HYPOTHETICAL PROTEIN" FT /note="Mb0213c, -, len: 242 aa. Equivalent to Rv0207c, len: FT 242 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 242 aa overlap). Conserved hypothetical FT protein, equivalent to Z95398|MLCL622_19 from Mycobacterium FT leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in FT 199 aa overlap)." FT /db_xref="UniProtKB/TrEMBL:Q7U2K4" FT /protein_id="CAD93077.1" FT /translation="MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVWD FT APNLDMGLGSILGRRPTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNIAP FT GSAEVVRPWVDALRNVGFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASADGQ FT AFRQPLEAVARSGTPVQVLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGLDSLP FT EQGAWLQPFRPLSSLLTSRV" FT CDS complement(248311..249102) FT /transl_table=11 FT /gene="Mb0214c" FT /locus_tag="Mb0214c" FT /product="HYPOTHETICAL METHLYTRANSFERASE (METHYLASE)" FT /EC_number="2.1.1.-" FT /note="Mb0214c, -, len: 263 aa. Equivalent to Rv0208c, len: FT 263 aa, from Mycobacterium tuberculosis strain H37Rv FT (100.0% identity in 263 aa overlap). Hypothetical FT methyltransferase (EC 2.1.1.-), equivalent to FT Z95398|MLCL622_20 from Mycobacterium leprae (279 aa), FASTA FT score: (64.2% identity in 246 aa overlaps). Also similar to FT others e.g. FT 10178368|CAC08407.1|AL392177|Q9F305|MT04_STRCO|SCD17A.03c FT HYPOTHETICAL METHLYTRANSFERASE from Streptomyces coelicolor FT (271 aa). Could start at aa 7." FT /db_xref="GOA:P67499" FT /db_xref="InterPro:IPR003358" FT /db_xref="UniProtKB/Swiss-Prot:P67499" FT /protein_id="CAD93078.1" FT /translation="MVHHGQMHAQPGVGLRPDTPVASGQLPSTSIRSRRSGISKAQRET FT WERLWPELGLLALPQSPRGTPVDTRAWFGRDAPVVLEIGSGSGTSTLAMAKAEPHVDVI FT AVDVYRRGLAQLLCAIDKVGSDGINIRLILGNAVDVLQHLIAPDSLCGVRVFFPDPWPK FT ARHHKRRLLQPATMALIADRLVPSGVLHAATDHPGYAEHIAAAGDAEPRLVRVDPDTEL FT LPISVVRPATKYERKAQLGGGAVIELLWKKHGCSERDLKIR" FT CDS 249234..250319 FT /transl_table=11 FT /gene="Mb0215" FT /locus_tag="Mb0215" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0215, -, len: 361 aa. Equivalent to Rv0209, len: FT 361 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.7% identity in 361 aa overlap). Hypothetical unknown FT protein." FT /db_xref="UniProtKB/TrEMBL:Q7U2K3" FT /protein_id="CAD93079.1" FT /translation="MRGQGHQIFVDELARFATSSADQRVVAIAQRAAEPLRVAVRGRPG FT VGCRTVARALQGAGSSSGMTVTPQARAADSDVDLVVYVTVEVVKPEDREAIAATRRPVV FT AVLNKADLAGPLSGAGPIVMAQARCAQFSTLLGVPMESMIGLLAVAALDDLDDTLRAAL FT RALAAHPDGFDALDRAVAGFLAAALPVPTEVRLRLLDTLDLFGIALGMAAFRPGRPSRT FT PAQLRTLLRRVSGVDAVIDKVTAAGSEVRYRRLLDAVAELEALAAQAKEIGGPIGEFLR FT DDDTVLARMAAAVDVALAVGLDVGPLDDPAAHLPRAVRWHRYSLDNGDMHRTCGADIAR FT GSLRLWSLAGGMPLHRYRKSS" FT CDS 250316..251794 FT /transl_table=11 FT /gene="Mb0216" FT /locus_tag="Mb0216" FT /product="HYPOTHETICAL PROTEIN" FT /note="Mb0216, -, len: 492 aa. Equivalent to Rv0210, len: FT 492 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 492 aa overlap). Hypothetical unknown FT protein. Possibly membrane protein; has hydrophobic FT stretches around aa 333 - 381." FT /db_xref="UniProtKB/TrEMBL:Q7U2K2" FT /protein_id="CAD93080.1" FT /translation="MIRAASDDPAGVDELVAAIAPGLAGLGLPVINRREVVLVTGPWLA FT GVSGVRAALAERLPQRRFVETAELGPGDAPVAVVFVVSAATALTESDCVLLDTAAEHTD FT AVVAVVSKIDVHRGWRDVLTSNRDRLAARASRYARVPWVGAAAAPELGEPYLDDLVAAI FT QKQLADPAVARRNMLRAWESRLLMVARRFDGDAQSAGRRARVDALRQQRRTVLRQGRQS FT KSEHTIALRAQIQHARVKLSYFARNRCSLLRVELQEHVAGLSRKDIARFAAYTRGRVQE FT VVAEVGEGAVAHLADVAQLLGVPVQPPVLENLPAVLPTVVAPPLTSRRLEIRLTTLLGA FT GFGLGIALTLSRLVAGLTPGLAASGMVAGVAIGLAVTAWVVNARALLHDRVVVDRWTGE FT VTASLRSVVEQLVATRVVAVETLLSTAISERDDAENARVADQVSIIDGELREHAVAAAR FT AAALRDREMPAVRAALEAVRAELGEPGTPTTGLF" FT CDS 251978..253798 FT /transl_table=11 FT /gene="pckA" FT /locus_tag="Mb0217" FT /standard_name="pckG; pck1" FT /product="PROBABLE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] FT PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP FT CARBOXYKINASE)" FT /EC_number="4.1.1.32" FT /note="Mb0217, pckA, len: 606 aa. Equivalent to Rv0211, FT len: 606 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 606 aa overlap). Probable pckA FT (alternate gene names: pckG and pck1), phosphoenolpyruvate FT carboxykinase [GTP] (EC 4.1.1.32), equivalent to FT Z95398|MLCL622_21 PROBABLE PHOSPHOENOLPYRUVATE FT CARBOXYKINASE from Mycobacterium leprae (609 aa), FASTA FT score: (86.1% identity in 605 aa overlap). Also highly FT similar to others e.g. PPCK_NEOFR|P22130 FT phosphoenolpyruvate carboxykinase [GTP] (608 aa), FASTA FT scores: opt: 2287, E(): 0, (55.9% identity in 598 aa FT overlap). Contains PS00505 Phosphoenolpyruvate FT carboxykinase (GTP) signature. BELONGS TO THE FT PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] FAMILY." FT /db_xref="GOA:P65687" FT /db_xref="HSSP:1KHB" FT /db_xref="InterPro:IPR008210" FT /db_xref="UniProtKB/Swiss-Prot:P65687" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAD93081.1" FT /translation="MTSATIPGLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEEF FT QRLCDQLVEAGTFIRLNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNWMD FT PGEMRSIMKDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMTRMG FT KAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGSGYGG FT NALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAML FT QPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGN FT TVFTNVALTDDGDVWWEGLEGDPQHLIDWKGNDWYFRETETNAAHPNSRYCTPMSQCPI FT LAPEWDDPQGVPISGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSEQTAAAEGKVGN FT VRRDPMAMLPFLGYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDGRFLWPGFGE FT NSRVLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALAVDADEWRQEL FT PLIEEWLQFVGEKLPTGVKDEFDALKERLG" FT CDS complement(253865..254836) FT /transl_table=11 FT /gene="nadR" FT /locus_tag="Mb0218c" FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN NADR FT (PROBABLY ASNC-FAMILY)" FT /note="Mb0218c, nadR, len: 323 aa. Equivalent to Rv0212c, FT len: 323 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 323 aa overlap). Possible nadR FT (alternate gene name: nadI), transcriptional regulator, FT similar to others e.g. NADR_ECOLI|P27278 transcriptional FT regulator from Escherichia coli (410 aa), FASTA scores: FT opt: 377, E (): 1e-17, (31.1% identity in 347 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q7U2K1" FT /db_xref="InterPro:IPR016429" FT /db_xref="UniProtKB/TrEMBL:Q7U2K1" FT /protein_id="CAD93082.1" FT /translation="MTHGMVLGKFMPPHAGHVYLCEFARRWVDELTIVVGSTAAEPIPG FT AQRVAWMRELFPFDRVVHLANENPQRPWEHPDFWDIWKASLQGVLATRPDFVFGAEPYN FT ADFAQVLGARFVAVDHGRTVVPVTATDIRADPLGHWQHIPRCVRPAFVKRVSIIGPEST FT GKTTLAQAVAEKLRTKWVPERAKMLRELNGGSLIGLEWAEIVRGQIASEEALARDADRV FT LICDTDPLATTVWAEFLAGGCPQELRDLARRPYDLTLLTTPDVPWDADDGRCVPGARGT FT FFARCEQALRAAGRSFVVITGGWEERLSVSLRAVEELVRARR" FT CDS complement(254833..256146) FT /transl_table=11 FT /gene="Mb0219c" FT /locus_tag="Mb0219c" FT /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" FT /EC_number="2.1.1.-" FT /note="Mb0219c, -, len: 437 aa. Equivalent to Rv0213c, len: FT 437 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 437 aa overlap). Possible FT methyltransferase (EC 2.1.1.-), weakly similar to others FT methyltransferases e.g. AF127374_30|LINA from Streptomyces FT lavendulae (611 aa), FASTA scores: opt: 400, E(): 8.1e-19, FT (27.3% identity in 388 aa overlap); Q50258 fortimicin kl1 FT methyltransferase (553 aa), FASTA scores: opt: 267, E(): FT 1.2e-13, (29.3% identity in 351 aa overlap)." FT /db_xref="GOA:Q7U2K0" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:Q7U2K0" FT /protein_id="CAD93083.1" FT /translation="MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPR FT LVGFSCIDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGE FT VAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADG FT FAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSIT FT DDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFI FT GVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVR FT LLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVV FT AKVAPDVGISFDEAEAYFLSRLDEWENVIAGRIAEATS" FT CDS 256260..257873 FT /transl_table=11 FT /gene="fadD4" FT /locus_tag="Mb0220" FT /product="PROBABLE FATTY-ACID-COA LIGASE FADD4 FT (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)" FT /EC_number="6.2.1.-" FT /note="Mb0220, fadD4, len: 537 aa. Equivalent to Rv0214, FT len: 537 aa, from Mycobacterium tuberculosis strain H37Rv, FT (99.8% identity in 537 aa overlap). Probable fadD4, FT fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many FT e.g. 4CL_PINTA|P41636 4-coumarate--coa ligase (EC 6.2.1.12) FT (537 aa), FASTA scores: opt: 622, E(): 1e-31, (30.0% FT identity in 514 aa overlap). Also similar to others from FT Mycobacterium tuberculosis e.g. MTCY6A4.14 FASTA score: FT (30.7% identity in 501 aa overlap); MTCY493_27, FT MTCY07A7_11, MTCI28_6. Contains PS00455 putative FT AMP-binding domain signature." FT /db_xref="GOA:Q7U2J9" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q7U2J9" FT /protein_id="CAD93084.1" FT /translation="MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIAADKPA FT VILYPSGTVISFDELEARANRLAHWFRQAGLREDDVVAILMENNEHVHAVMWAARRSGL FT YYVPINTHLTASEAAYIVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGGGLV FT |