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EBI DbfetchID AY854631; SV 1; linear; mRNA; STD; MAM; 2600 BP. XX AC AY854631; XX DT 12-JAN-2005 (Rel. 82, Created) DT 14-NOV-2006 (Rel. 89, Last updated, Version 3) XX DE Bos taurus methylenetetrahydrofolate reductase (MTHFR) mRNA, complete cds. XX KW . XX OS Bos taurus (cattle) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. XX RN [1] RP 1-2600 RA Charest R., Beaudry D., Girard C., Palin M.F.; RT "Interactions folic acid-vitamin B12-methionine: effects on liver RT metabolism and production of dairy cows"; RL Unpublished. XX RN [2] RP 1-2600 RA Charest R., Beaudry D., Girard C., Palin M.F.; RT ; RL Submitted (13-DEC-2004) to the EMBL/GenBank/DDBJ databases. RL Dairy and Swine Research and Development Centre, P.O. Box 90, 2000 Route RL 108 East, Lennoxville, Quebec J1M 1Z3, Canada XX DR Ensembl-Gn; ENSBTAG00000020698; Bos_taurus. DR Ensembl-Tr; ENSBTAT00000027586; Bos_taurus. DR Ensembl-Tr; ENSBTAT00000052193; Bos_taurus. XX FH Key Location/Qualifiers FH FT source 1..2600 FT /organism="Bos taurus" FT /mol_type="mRNA" FT /tissue_type="liver" FT /db_xref="taxon:9913" FT gene 1..2600 FT /gene="MTHFR" FT CDS 192..2159 FT /codon_start=1 FT /gene="MTHFR" FT /product="methylenetetrahydrofolate reductase" FT /function="irreversible conversion of FT 5,10-methylene-tetrahydrofolate in FT 5-methyl-tetrahydrofolate" FT /note="involved in folate metabolism" FT /db_xref="GOA:Q5I598" FT /db_xref="InterPro:IPR003171" FT /db_xref="InterPro:IPR004621" FT /db_xref="UniProtKB/Swiss-Prot:Q5I598" FT /protein_id="AAW39033.1" FT /translation="MVNEPRGNGSPGPRWEGSSSGSESSRTSSRCSTPGLDPERCERLR FT EKMKRKMDSGDKWFSLEFFPPRTAQGAVNLISRFDRMGAGGPLFVDVTWHPAGDPGSDK FT ETSSMVIASTAVNYCGLETILHMTCCHQSREEITGHLNKAKQLGLKNILALRGDPIGDQ FT WEEEEGGFNYATDLVKHIRNEFGDYFDVCVAGYPKGHPEGESFEADLKHLKEKVAAGAD FT FIITQLFFEAETFFRFVKACSEIGITCPVLPGIFPIQGYHSLRQLVKLSKLEVPQQIKD FT VIEPIKDNDAAIRNYGIEQAVSLCQELLASGLVPGLHFYTLNREVATIEVLKRLGLWIE FT DPRRPLPWALSAHPKRRVEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGEL FT KDYYLFYLKSKSPKEELLKMWGEELTSEESVFQVFAHHLSGEPNQNGYKVTCLPWNDEP FT LAAETSLMKEELLRVNRRGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTS FT RETVEALLQVLKKYELRVNYHIVDVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDP FT VSFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLVDNEFPLDNCLWQVV FT EDTFELLSRPPQDKRETEAL" FT variation 445 FT /gene="MTHFR" FT /replace="a" FT variation 603 FT /gene="MTHFR" FT /replace="g" FT variation 942 FT /gene="MTHFR" FT /replace="a" FT variation 1001 FT /gene="MTHFR" FT /replace="a" XX SQ Sequence 2600 BP; 567 A; 779 C; 760 G; 494 T; 0 other; tcatcagtga ccagaggcgt gccagagtgg ctgaacacct tgagaagagc cgagggccgc 60 tggcactgct gtcccgacgc ccactgcatc gggctgcaca caagtgccca cccgggcccc 120 tctaagagtg gtggactcca gtatttctcc actgttgcgg gtgcctggca ccgattaaca 180 ggaactcggc catggtgaac gaacccagag ggaacggcag ccccggcccc cgctgggagg 240 gcagcagcag cggcagcgag agctcaagga caagttcaag gtgctccacg ccggggttgg 300 accccgagcg atgcgagaga ctccgggaga agatgaagcg gaagatggac tctggagaca 360 agtggttctc cctagagttc ttccctcccc gaactgccca gggtgctgtc aatctcatct 420 ccaggtttga ccggatggga gcgggtggcc ccctctttgt agacgtgacc tggcacccag 480 ccggggatcc tggctccgac aaggagacct cgtccatggt gattgccagc actgccgtga 540 actactgcgg cctcgagaca atcctgcaca tgacctgctg ccatcagagc cgtgaagaga 600 tcacgggcca cctgaacaaa gccaagcagc tgggcctgaa gaacatcctg gcgctgaggg 660 gagaccccat aggtgaccaa tgggaagagg aggaaggagg cttcaactat gctacggact 720 tggtgaagca catccgaaac gagtttggtg actactttga cgtctgtgtg gcaggttacc 780 ccaaaggcca ccctgaagga gagagctttg aggctgatct gaagcacctg aaggagaagg 840 tggctgcagg agccgacttc atcatcaccc agctattctt tgaggctgaa acattcttcc 900 gctttgtgaa ggcttgctcc gagataggca ttacctgccc cgtcctcccc ggcatcttcc 960 caattcaggg ctaccactcc ctccggcagc tggtgaaact gtccaaactg gaggtgccac 1020 agcagatcaa ggatgtgatc gagcccatca aagacaatga tgctgccatc cgcaactatg 1080 gcatcgagca ggccgtgagc ctgtgccagg agctgctggc cagtggcttg gttccaggcc 1140 tccacttcta caccctcaac cgcgaggtgg ccaccatcga ggtgctgaag cgcctggggc 1200 tttggattga ggaccctagg cgtcccctgc cctgggccct cagtgcccac cccaagcgcc 1260 gggtggagga tgtccggccc atcttctggg cctcgagacc aaagagttac atttaccgta 1320 cgcaggagtg ggacgagttc cccaatggcc gctggggcaa ttcctcctct ccggcctttg 1380 gggagctgaa ggactactac ctcttctacc taaagagcaa gtccccgaag gaggagctgc 1440 tcaagatgtg gggggaggag ctgaccagtg aggaaagcgt cttccaagtc tttgcccacc 1500 acctctcggg agagcccaac cagaatggct acaaagtgac ttgcctgccc tggaatgatg 1560 agcccctggc agccgagacc agcctgatga aggaggagct gctgagagtg aaccggcgag 1620 gcatcctcac catcaactcc cagcccaaca tcaacgggaa gccgtcctct gaccccatcg 1680 tgggctgggg ccccagtggg ggctatgtct tccagaaggc ctacttagag ttcttcactt 1740 cccgagaaac ggtggaggcg cttttgcagg tgctgaagaa gtatgaactc cgggtgaatt 1800 accacatcgt ggatgtgaag ggtgaaaata tcaccaacgc ccctgagctg caacccaacg 1860 cggtcacctg gggcatcttc cctggccgag agatcatcca gcccacagtg gtggacccgg 1920 tcagcttcat gttctggaag gatgaggcct tcgcgctgtg gattgagcag tggggcaagc 1980 tgtatgagga ggagtccccc tcccgcatga tcatccagta catccacgac aactacttcc 2040 tggtcaacct ggtggacaac gagtttccgc tggacaactg cctgtggcag gtggtggaag 2100 acacgtttga gcttctcagc aggccccccc aagacaagag ggagacagag gcgctgtgac 2160 cctgcaccct gacaacctta gcttgaggcc actgtgtccc gccttcctca tctccatcct 2220 ggctctttgg gagacccctg ttcttcgttt ctccccagcc ctggcctcca ccttctgaca 2280 caatgatggc agctagactg gtgtgaggtt cccaggctct ggctagactt gagtccgccc 2340 cacacgggaa cctggtgttc ctgctcagct gagagtctgt gctctggtgg ggagcagcca 2400 cttccacaaa gaccccatgg acagaacgcc gtccaccccg agaagggctg ttgctaatag 2460 agccccttgg ggccagcctg ggactgactg ccagtgacct tgctcctggg cgccaggaga 2520 acagcaaagt gaacattgca gcaggccctg tgggactgca gaagaaacac ggcaaggtca 2580 tagcgcctca cccttcacct 2600 // |
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