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EBI DbfetchID AY135660; SV 1; linear; genomic DNA; STD; PRO; 12698 BP. XX AC AY135660; XX DT 24-SEP-2002 (Rel. 73, Created) DT 18-NOV-2008 (Rel. 97, Last updated, Version 5) XX DE Aquifex pyrophilus hydrogenase small subunit (mbhS1) gene, partial cds; and DE hypothetical protein, phosphatidate cytidylytransferase (cds), undecaprenyl DE pyrophosphate (yaes), hypothetical protein, DE 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase (kdsA), molybdenum DE transport system permease (modB), riboflavin synthase beta subunit (ribH), DE transcription termination factor (nusB), hypothetical protein, NADH DE dehydrogenase (nuo), cytochrome c peroxidase (ccpR), heat shock protein 70 DE (dnaK), and hypothetical protein genes, complete cds. XX KW . XX OS Aquifex pyrophilus OC Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex. XX RN [1] RC Publication Status: Available-Online prior to print RP 1-12698 RX DOI; 10.1074/jbc.M404561200 RX PUBMED; 15308670. RA Shulami S., Furdui C., Adir N., Shoham Y., Anderson K.S., Baasov T.; RT "A reciprocal single mutation affects the metal requirement of RT 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthases from Aquifex RT pyrophilus and Escherichia coli"; RL J. Biol. Chem. 279(43):45110-45120(2004). XX RN [2] RP 1-12698 RA Shulami S., Yaniv O., Shoham Y., Baasov T.; RT ; RL Submitted (24-JUL-2002) to the EMBL/GenBank/DDBJ databases. RL Department of Food Engineering and Biotechnology, Technion-Israel Institute RL of Technology, Hifa 32000, Isarel XX FH Key Location/Qualifiers FH FT source 1..12698 FT /organism="Aquifex pyrophilus" FT /mol_type="genomic DNA" FT /db_xref="taxon:2714" FT gene complement(<1..842) FT /gene="mbhS1" FT CDS complement(<1..842) FT /codon_start=1 FT /transl_table=11 FT /gene="mbhS1" FT /product="hydrogenase small subunit" FT /db_xref="GOA:Q8GLL2" FT /db_xref="HSSP:1FRF" FT /db_xref="InterPro:IPR006137" FT /db_xref="UniProtKB/TrEMBL:Q8GLL2" FT /protein_id="AAN12285.1" FT /translation="MPKVVKALETKPKPVVIWLEFQDCAGCSESFIRSTSLLPTEVLLE FT FISLEYHETLMAPSGDYAEESKREAIEKYKGKYILVVEGSVTPNGVYCTVGGRSNYELL FT KEAAENAAFVVSVGSCASWGGIPKASPNPTGAVPVYEVIKDKTVVNVPGCPPIGDVLVA FT TIVHYLALGKLPPLDGLGRPKTFYGETIHDRCYRRAFYNAGKFAESFDDEKARKGYCLY FT KLGCKGPITRNACPTIRWNGSLSFPIQSGHPCFGCSEPDFWDRGFIYKPLSVVEEGIS" FT CDS complement(1010..1450) FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="Orf1" FT /db_xref="InterPro:IPR014865" FT /db_xref="UniProtKB/TrEMBL:Q8GLL1" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN12286.1" FT /translation="MKRIFIFLFLFLSLSFSGERVLKSVFDCAIGDLDWINLRLSLIQN FT TAEMLIKEGKSYKFVITIHSYCIPIVDGDLNRYPKETREKIKLIQSKLKTLKELYEVDI FT KACNIAMKRMKIKNVPKFIEVVPNSWITLIELQNEGYAFVPF" FT gene complement(1469..2176) FT /gene="cds" FT CDS complement(1469..2176) FT /codon_start=1 FT /transl_table=11 FT /gene="cds" FT /product="phosphatidate cytidylytransferase" FT /db_xref="GOA:Q8GLL0" FT /db_xref="InterPro:IPR000374" FT /db_xref="UniProtKB/TrEMBL:Q8GLL0" FT /protein_id="AAN12287.1" FT /translation="MSRESYGLAIGLIVILITFLPLPLFAFFVCLLSFFVSKEVSKVFK FT EDISLFSPLILLVHHLLSPLTYPLIGLLALYRGYKTWSIESFLKVVFLGFYPALFLSYL FT IGIREKGVFITLVFIFGIWINDVFAYYTGKYFGKTPLFPKISPKKTLEGLLGGLIPASL FT FYGFLLPEDFLKAFFIGMITLVFGVAGDYFKSFIKRQYHIKDFSNILGEHGGFADRFDA FT IIFSSPVFYFFIN" FT gene complement(2169..2864) FT /gene="yaes" FT CDS complement(2169..2864) FT /codon_start=1 FT /transl_table=11 FT /gene="yaes" FT /product="undecaprenyl pyrophosphate" FT /db_xref="GOA:Q8GLK9" FT /db_xref="HSSP:1UEH" FT /db_xref="InterPro:IPR018520" FT /db_xref="UniProtKB/Swiss-Prot:Q8GLK9" FT /protein_id="AAN12288.1" FT /translation="MSLKIPEHVAIIMDGNGRWARKRGLPRIAGHYKGAEVAEDIVEFA FT IELGIKHLTLFAFSTENWNRPKGEVEALFELLRRYLQTKKDKLYKLGIRVRFIGRRDRI FT NKELVKLMQEIEEESKKFKNLFLNLAVDYGGRDDILRAVKKAVKLQREEITEELFSSLL FT DLSCSPDPDLLIRTAGEKRISNFLLWNLAYTELYFSETLWPDFSREEFLKALEDFSRRK FT RKFGRVLDE" FT CDS complement(2864..3565) FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="Orf2" FT /db_xref="GOA:Q8GLK8" FT /db_xref="InterPro:IPR013026" FT /db_xref="UniProtKB/TrEMBL:Q8GLK8" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN12289.1" FT /translation="MVSVNIILVMRKGMLLLPILIIACAPVSEKEIKIMKKRISEFEGR FT VAKLEERQEETGEKLEIINERVDKIAQEVGEIKRRIYLKTEKGEELIEEETSKSLEEIE FT ENPEEEYREALNPYKMKRLNEARDAFVNFIKKYPKTNLTDNAYFWLGTIYYELGNEERA FT LQILKTLIGKCKEGRLPDCNKLPDTYYMLVKIYAEEGNESEAERYLNRLKEEFPDTPLI FT EKAEKVLYKNE" FT gene 3564..4367 FT /gene="kdsA" FT CDS 3564..4367 FT /codon_start=1 FT /transl_table=11 FT /gene="kdsA" FT /product="3-deoxy-D-manno-2-octulosonate-8-phosphate FT synthase" FT /db_xref="GOA:Q8GLK7" FT /db_xref="HSSP:1PCK" FT /db_xref="InterPro:IPR006269" FT /db_xref="UniProtKB/TrEMBL:Q8GLK7" FT /protein_id="AAN12290.1" FT /translation="MEKFLIIAGPCAIESESLVLRVAEKIRELQDKFRDVEFVFKSSFD FT KANRSSIHSFRGHGLDYGLKALRRVKEEFGLKTTTDIHESWQAEPVGEVVDIIQIPAFL FT CRQTDLLLAAAKTGKPVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTSFGYNNL FT VVDFRSLPIMKQYAKVIYDATHSVQLPGGLGDKSGGMREFIFPLLRAAVAVGCDGVFME FT THPEPEKALSDSATQLPLGELDGIVEAILEIKQVAEKYYEKPANV" FT gene 4360..5022 FT /gene="modB" FT CDS 4360..5022 FT /codon_start=1 FT /transl_table=11 FT /gene="modB" FT /product="molybdenum transport system permease" FT /db_xref="GOA:Q8GLK6" FT /db_xref="InterPro:IPR011867" FT /db_xref="UniProtKB/TrEMBL:Q8GLK6" FT /protein_id="AAN12291.1" FT /translation="MFEALIVSLKLAFLTTIILMLLSLIISPLISFKEFRGKGFLLSLF FT TLPLVLPPTVLGFYLILLLSPESLLGRLAKKLFGTSLLFTFEGILLASLVYSFPLAVLP FT VINVMEKVKKEYMETAYIFGYSPIETYVKVVLPLSLEGIITACILVFVHTLGEFGVILM FT VGGNIPGETQTLSIYVYDSVQALDYRSAHIASLILLSIALISTILVYLFGKRKGLKY" FT gene 5027..5491 FT /gene="ribH" FT CDS 5027..5491 FT /codon_start=1 FT /transl_table=11 FT /gene="ribH" FT /product="riboflavin synthase beta subunit" FT /db_xref="GOA:Q8GLK5" FT /db_xref="HSSP:1HQK" FT /db_xref="InterPro:IPR002180" FT /db_xref="UniProtKB/Swiss-Prot:Q8GLK5" FT /protein_id="AAN12292.1" FT /translation="MKTYEGELIAEGLRFGIVASRFNHALVDRLVEGAIDCILRHGGRE FT EDITLVRVPGSWEIPVAVGELARREEIDAVIAIGVLIRGATPHFDYIASEVSEGLANLS FT LELRKPITFGVITADTLEQAIERAGTKHGNKGWEAALSAIEMANLFKKLR" FT gene 5488..5922 FT /gene="nusB" FT CDS 5488..5922 FT /codon_start=1 FT /transl_table=11 FT /gene="nusB" FT /product="transcription termination factor" FT /db_xref="GOA:Q8GLK4" FT /db_xref="InterPro:IPR006027" FT /db_xref="UniProtKB/TrEMBL:Q8GLK4" FT /protein_id="AAN12293.1" FT /translation="MRYRKSARDTAFLVLYRWDLRGDKPSEIFKEVVEEKNIQNKNTYE FT YAKKLVETTVNNISEIDAIIEKHLKGWSIDRLGYVERNALRLGVAELLFLKSQEPGRVF FT IDIIDIVKKFTDEKAAKFVNGVLSAIYRSFLEKKKEKVKN" FT CDS 6129..6581 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="Orf3" FT /db_xref="InterPro:IPR005268" FT /db_xref="UniProtKB/TrEMBL:Q8GLK3" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN12294.1" FT /translation="MRQISVIGSSRANEEEYEVAYGLGKELAKLGLVVVCGGRTGVMEA FT VCKGAKEEGGLTVGILPSYDGHEANPYVDIKINTGLSWNRNPLVVASGEMVVAIGGNYG FT TLSEIAYALILGKYVVGYKTHKVDGVKQVSSLKEILEEVKKFFGRA" FT gene 6582..7526 FT /gene="nuo" FT CDS 6582..7526 FT /codon_start=1 FT /transl_table=11 FT /gene="nuo" FT /product="NADH dehydrogenase" FT /db_xref="GOA:Q8GLK2" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q8GLK2" FT /protein_id="AAN12295.1" FT /translation="MKVFITGSTGFVGRHITRKLLEEGHEVVAGVRSLEKLRNLFGDSV FT RGIKLDFENRKEVFYVLNREKPDAVIHLIGILYELPSKGITFFKVHYLYTKYLVEASKN FT AGVRKFLFMSALGTHDLAPSWYHQTKKWAEKEVINSGLNYTIFRPSIILGPEQKLFYDM FT NKITKLLPVVALPDFGKYPFQPVDVRDVACAYAEALKNPETDRKIYELCGTKVVSFKEL FT LSDIFSHWKRKVLMIPLPKSLMYIPAYILEKILEPPPFSRDQLRMMWKPNVCGALEDEA FT VKEGIKAICKRNPISYEESIKWSLEQFDIIFNR" FT gene 7553..8620 FT /gene="ccpR" FT CDS 7553..8620 FT /codon_start=1 FT /transl_table=11 FT /gene="ccpR" FT /product="cytochrome c peroxidase" FT /db_xref="GOA:Q8GLK1" FT /db_xref="HSSP:1IQC" FT /db_xref="InterPro:IPR009056" FT /db_xref="UniProtKB/TrEMBL:Q8GLK1" FT /protein_id="AAN12296.1" FT /translation="MRKLALALALFSGFGLGASEKGNSEDMKLLEMAKQYFKPLPKVAE FT NPVTPREVKLGKMLYYDPRLSKSGLISCNTCHNLARYGVDNLPTSIGHRWAIGPRNAPT FT VYNAAIHIAQFWDGRAKDVEEQALGPIVNPIEMANTEENVVKTLKSIPEYVELFKKAFP FT NEKDPVKYVNIGKAIGAFERTLMTPSGFDEFLKGNTDALTEQEKRGLKTFIEVGCAGCH FT NGAGVGGHMFAKFGAITEYWKATYPYVLKEKPTIKVDFGRFGVTKNEADIFVFKVPSLR FT NIEHTYPYFHDGSVWSLEDAVRIMAKTQLGKELTDQQVKDIVAFLKALTGEIPKHALEV FT PELPPSRENTPKPQF" FT gene 8746..10632 FT /gene="dnaK" FT CDS 8746..10632 FT /codon_start=1 FT /transl_table=11 FT /gene="dnaK" FT /product="heat shock protein 70" FT /db_xref="GOA:Q8GLK0" FT /db_xref="HSSP:1DKG" FT /db_xref="InterPro:IPR018181" FT /db_xref="UniProtKB/TrEMBL:Q8GLK0" FT /protein_id="AAN12297.1" FT /translation="MAEKKEKIIGIDLGTTNSVVAVMMGDEAVVIQNQEGSRLTPSVVS FT WTKEKEVLVGDPAKRRAILDPENTVYESKRFIGRKFEEVKEEAKRVSYKVVPDEKGDAA FT FDIPNAGKLVRPEEVGAHVLRKLKEAAEAFLGEPVKKAVITVPAYFNERQRQATKDAGK FT IAGLEVVRILNEPTAAAMAYGLHKKENVRILVYDFGGGTFDVSILEGGDGVIEVKATAG FT DTHLGGANIDERIMEWLIEEFKKEHGIDLRQDRTVLQRLKEAAEQAKKELSFKMETEIN FT LPFITIDPNTNQPLHLQKKLTRARLEEMINDLIDRTIDIVKQALEDAKLKPSDIDEVVL FT VGGSTRIPLVQQKIKEFFGKEPHKGLNPDEVVAMGAAIQAGVLAGEVKEIVLVDVTPLS FT LGVETYGGVMTVLIPRNTPIPVRKCEVFTTAHDYQTEVEIHVLQGERPLAKDNKSLAKF FT YLTGIPPAPRGVPKIEVCFDIDADGILHVTAKDLGTGKEQSVRVEISSGLTPEEIERII FT KEAEEHAEEDRKKKELIEAKNQLDHLVYQLEKTLKEAGDKVPADVKQEAEKVIEEAKKT FT IETATDINEVKRVTERVLQVSSKLGTTLYGEAGKTEKKDEGGEGEVEAKPVD" FT misc_feature complement(10803..11513) FT /note="similar to lipid A disaccharide sythase; lpxB" FT CDS complement(11510..11821) FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="Orf4" FT /db_xref="UniProtKB/TrEMBL:Q8GLJ9" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN12298.1" FT /translation="MPADPRNAGKDKGTLEMELKNLLTSARIRKMEYEAIVDELEEDEL FT KYDLFEYKEYYETNVKPYIDKAYKNGNEKLVAMAEEIKGIFEEIIDMITARIEELSKK" XX SQ Sequence 12698 BP; 3653 A; 2883 C; 2961 G; 3200 T; 1 other; aagcttattc cttcttccac aaccgagaga ggcttgtaaa tgaatcccct gtcccagaaa 60 tcgggctcgg agcatccgaa acagggatgt ccagactgta tggggaagct caggcttccg 120 ttccacctta tcgtggggca cgcgttcctc gttatgggcc ccttacagcc gagtttataa 180 aggcagtatc cctttctcgc cttttcgtcg tcaaaggatt ccgcaaactt tccggcgttg 240 taaaaggccc tcctgtaaca cctgtcgtga atagtctccc cgtaaaaggt cttcggcctt 300 ccgagaccgt cgaggggagg gagcttcccg agggcaaggt aatgaactat ggtcgcaacc 360 aatacgtccc ctatgggagg acatccggga acgttcacaa ctgttttatc ctttattacc 420 tcgtatacgg gaaccgcacc agttggattt ggagatgcct taggaatgcc tccccaggaa 480 gcacagcttc ctaccgaaac gacgaacgcg gcattctccg cagcttcttt caggagctcg 540 tagtttgacc ttcctcccac ggtgcagtaa acgccgttcg gagtcacaga gccctcaaca 600 acgagtatat acttgccctt gtacttctca atggcttccc tctttgactc ttccgcgtaa 660 tctccagaag gcgccataag cgtttcgtga tactcaaggg atataaactc aagaaggact 720 tccgttggaa gcagggaggt tgaccttatg aaggactctg aacatccagc acaatcctga 780 aactcaagcc atatgacaac tggctttggc ttcgtttcca gagcctttac cactttcggc 840 atgagggaag gaggaagtcc taaaaccgcg gtcgttaagg ttgcgaactt aaggaaatcc 900 cttcttgtat aacctttatc cttaaagact tcaaaaagcg tcttcaatta agcccctcca 960 tatggggtaa tatattgtga tttttatcag atgcaataat aattgatttt cagaagggaa 1020 cgaatgcgta accctcgttc tggagctcta tgagcgttat ccagctgttc gggacaacct 1080 ctataaactt agggacattt ttaatcttca tccttttcat agctatgttg caggccttta 1140 tatcaacctc gtaaagctcc tttaacgtct tcagtttaga ctgaatgagc ttaatcttct 1200 cccttgtttc cttgggatac ctattcaggt ctccgtcaac aatcggaatg cagtaagagt 1260 gtatagttat aacgaattta taggatttcc cctcttttat gagcatctca gcagtattct 1320 gaataagaga gagcctgaga tttatccagt caaggtctcc aatagcacag tcaaaaacag 1380 actttaaaac cctttctcca gaaaaggaaa gggaaaggaa aaggaatagg aatataaaaa 1440 ttcttttcat aactcacctc cctaaaactt aatttatgaa gaagtaaaag acgggagaag 1500 agaagatgat tgcgtcaaac ctgtcagcga atcctccgtg ttccccaaga atatttgaga 1560 agtccttaat gtggtattgt ctctttatga aggatttgaa gtaatcccct gcgacaccga 1620 agactagcgt aatcattcct atgaagaaag cctttaaaaa atcttcaggt agaaggaatc 1680 cgtaaaataa ggatgcggga attaaacccc ctaataatcc ctcaagggtt ttcttaggtg 1740 agattttagg aaataaagga gtttttccga aatactttcc cgtgtagtaa gcgaaaacgt 1800 cgtttatcca tataccgaat ataaaaacga gagttatgaa aacccccttt tcccttatac 1860 ctataaggta agaaagaaag agagcagggt aaaagccgag aaaaacaact ttgagaaagg 1920 attcaattga ccatgtttta taccccctgt aaagggcaag aagaccgatt aagggataag 1980 taagtggact tagaagatga tgaacaagca gtataagggg tgagaataaa gagatatctt 2040 ctttaaaaac ctttgaaact tcctttgata caaaaaagga aagaagacat acgaaaaaag 2100 caaacaaggg aaggggtaaa aaggtaatga gtataacgat aaggcctatt gccaatccgt 2160 angattccct actcatcaag cacccttccg aacttcctct ttctccttga gaagtcctcg 2220 agggctttta agaactcctc cctgctgaag tctggccaaa gtgtttcgga aaagtacagc 2280 tctgtgtaag cgagattcca aaggaggaag tttgatatcc ttttttcacc cgcagttctt 2340 atgaggaggt cggggtcggg ggaacaggag agatcaagaa ggctagagaa tagctcttca 2400 gttatctcct ccctctggag ctttacagct ttttttaccg ccctcagtat gtcgtccctt 2460 cccccgtaat caacagcgag gttcagaaac aaatttttaa acttctttga ttcttcctct 2520 atctcctgca ttagcttcac aagttccttg tttatcctgt ccctcctccc gatgaagcga 2580 actcttatcc cgagtttata aagcttatcc ttctttgtct ggaggtatct cctcaaaagc 2640 tcaaataaag cttcaacttc ccctttcggt ctattccagt tttccgttga gaaggcgaag 2700 agcgttagat gttttatacc gagctcaatt gcaaactcaa ctatatcctc cgcaacttcc 2760 gcacctttgt aatgcccggc tatacggggg agcccccttt tccttgccca ccttccgttt 2820 ccgtccatta ttatagctac gtgctcggga attttaagac tcattactca tttttgtata 2880 aaaccttctc agccttttca ataaggggcg tgtccgggaa ctcctctttt aatctgttta 2940 aatacctttc ggcttcgctt tcgtttcctt cttccgcata aatctttacg agcatgtaat 3000 aggtgtcggg aagcttattg cagtcgggaa gtctaccttc cttacacttg cctataagcg 3060 ttttgagtat ctgaagggct ctctcttcgt taccgagctc atagtatata gttccgagcc 3120 agaagtaagc gttatccgtt aagttcgttt tgggatactt tttgatgaag ttcacaaagg 3180 catcccttgc ctcgttaagt cttttcatct tgtaagggtt tagggcttcc ctgtactctt 3240 cctccggatt ttcctcaatc tcttctaagg atttagaagt ttcctcttca atcaactctt 3300 ctcctttttc cgtttttagg taaattctcc tctttatctc cccgacctct tgcgcaattt 3360 tgtctaccct ctcgttaatt atttccaatt tctcgcccgt ttcctcctgc ctctcttcca 3420 gtttagcgac gcgtccctca aactcgctta tcctcttttt cataattttt atttcctttt 3480 ccgagacggg agcacaggca ataattaaaa ttgggagtaa taacatcccc tttctcatga 3540 ccagtattat attaacagat accatggaaa aatttctgat aatagcggga ccctgtgcaa 3600 tagagagcga gtctcttgtt ctgagagtag cggagaagat tagggagctt caggataaat 3660 tcagggacgt tgagttcgtg tttaagtcct cctttgataa ggctaaccgc tcctccatac 3720 actctttcag ggggcacggg cttgattacg gcctgaaggc tcttaggcgt gtaaaggagg 3780 agttcgggct gaaaacgacg acggatatcc acgagagctg gcaggcggag cccgtcgggg 3840 aagttgttga tatcatccag atacccgcat tcctgtgcag acagacggac ctccttcttg 3900 ccgcggcaaa aacgggaaag ccggtaaacg ttaagaaagg gcagttttta gccccgtggg 3960 atacaaagaa cgttgttgag aagcttaagt tcggaggagc taaggagatt tacctcacgg 4020 agaggggaac gagcttcgga tataacaacc tcgttgttga ttttcgcagt ctccccataa 4080 tgaaacaata cgctaaggtt atttacgatg cgacacacag cgttcagctc cccggaggtt 4140 tgggagacaa atccggagga atgagggagt ttatcttccc tctactcagg gcagcggtcg 4200 cggtcggttg cgacggcgtt tttatggaga cacaccccga gcccgagaaa gccctatcgg 4260 attccgcaac ccagcttccc ctcggagagc ttgatgggat agttgaggct atacttgaga 4320 taaaacaagt ggctgagaag tattacgaaa aacccgctaa tgtttgaggc cctaatcgta 4380 agccttaagc ttgccttcct cacaaccata atccttatgc ttctttccct aataatctca 4440 cccctcatct cctttaagga attcagggga aagggatttc tcctctccct ttttacccta 4500 cccctcgtcc ttccaccgac ggttctcggt ttttacctta ttctccttct ctcccccgag 4560 agccttctcg ggaggcttgc caagaaactt ttcggaacgt ctcttctctt cacctttgag 4620 ggaattctcc tcgcatctct cgtttactcc tttcccctcg cggttcttcc cgtaattaac 4680 gttatggaga aggttaagaa ggagtatatg gagaccgctt acatattcgg ctactcacct 4740 atagaaacat acgttaaggt tgttcttccc ctctcccttg agggcatcat aaccgcctgc 4800 atacttgttt tcgttcacac cctcggggag ttcggcgtca ttcttatggt tggcgggaac 4860 atacccgggg aaacccagac actctccata tacgtatacg acagcgttca ggcccttgac 4920 tacagaagtg cccatatagc gagtcttata ctcctttcta ttgcccttat atcaacgatt 4980 ctcgtatacc tttttggtaa aagaaaaggc ctaaaatatt aacgttatga aaacgtatga 5040 aggagagctg atagcggaag gtttaagatt cggcatagtc gcctcccgtt ttaaccacgc 5100 actcgtggac agactcgttg agggagctat agactgcata ctgagacacg gaggaaggga 5160 ggaagacata acactcgtaa gagttcccgg ttcctgggag attcccgttg cggtagggga 5220 gctcgcaaga agggaggaga tagacgcggt aatagccata ggcgtcctca taaggggagc 5280 cactccccac tttgattaca tagcttccga ggtatcagag gggcttgcga acctttccct 5340 tgagctgaga aagcccataa ccttcggcgt tataaccgcg gacacccttg aacaggctat 5400 agaaagagct ggaacgaagc acggaaataa aggctgggag gctgcactct ccgcaataga 5460 aatggctaat ttatttaaga agctgagatg agatatcgga agagtgcaag ggataccgct 5520 ttcttagttc tttacaggtg ggacctgagg ggagataagc cctcagagat attcaaagaa 5580 gttgttgagg agaaaaacat tcagaataag aacacttacg agtacgctaa gaaacttgtt 5640 gagacaaccg tgaacaacat aagcgagata gacgcgataa tagagaaaca cttaaaaggc 5700 tggagcatag acaggctcgg gtacgttgag agaaatgcac tgaggctggg agtggcggag 5760 ctcttgttcc tcaaatctca ggagccggga agagttttca tagacataat agacatagtg 5820 aagaagttta ccgacgaaaa ggctgcaaag ttcgtaaacg gagtcctttc cgcaatttat 5880 cgctcatttc ttgaaaagaa gaaagagaag gttaagaatt aaggtgagga taatactcag 5940 aagtatagag gttactatcg gtatgtaaat cgtaaagtta tccctcttta tgagtatgtc 6000 cccgggcagt tttccgagtc cgaggggaag tttctcaaag agcattaata gaacaccggt 6060 gataacgaga atcagtccga agattaccag aagctttcca atttcaccca tcacttaaat 6120 tgtagtttat gagacagatt tccgtaatag gttcctcaag ggcaaatgag gaggagtatg 6180 aggtagccta cgggctcgga aaggagcttg ctaaactcgg tctcgttgtc gtgtgcggag 6240 ggagaaccgg cgtcatggaa gcggtgtgca aaggtgcaaa ggaggaaggg ggcctcacgg 6300 taggcatcct cccttcctac gacgggcacg aggcaaaccc ctacgttgat ataaagataa 6360 acacgggcct gagctggaac aggaatcccc tcgttgttgc gagcggtgag atggtcgttg 6420 ccataggcgg gaattacgga accctttcgg agatagctta cgccctaata ctcggaaaat 6480 atgtcgtcgg atacaaaacc cacaaggttg atggcgtgaa acaggtcagc tcccttaagg 6540 agattctcga agaggtaaaa aaattcttcg ggagggctta aatgaaggtg tttataaccg 6600 gctcaacggg atttgtaggg aggcatataa cgagaaagct ccttgaggaa gggcacgaag 6660 tagttgccgg cgtgagaagc ctggagaagc tgagaaacct tttcggggac tccgtaaggg 6720 gcataaaact tgactttgaa aacagaaaag aggtttttta tgtgttaaat agggaaaagc 6780 ccgacgcggt aatccacctt ataggcatac tttacgaact cccatcaaag ggaatcacct 6840 tctttaaggt tcattacctc tatacgaaat accttgttga ggcatcaaag aatgcgggag 6900 taaggaagtt cctctttatg agtgccctcg gaacccatga ccttgcgcct tcctggtatc 6960 atcaaacgaa gaagtgggcg gaaaaggagg ttataaactc gggccttaat tacaccattt 7020 tcagaccctc tataattctc ggtccagagc agaaactctt ttacgatatg aacaagatta 7080 caaagctcct tcccgttgta gccctccccg acttcgggaa gtatcccttc cagcctgttg 7140 atgtaaggga tgtcgcctgt gcctatgcgg aagccctcaa aaacccggaa accgaccgaa 7200 agatttacga gctttgcgga acaaaggtcg tgagctttaa ggaacttctc tccgatatat 7260 tctcccactg gaaaagaaag gttttaatga ttcccctacc caaaagcctc atgtatatac 7320 ccgcatacat acttgagaag atacttgagc ccccgccctt ctcaagggac cagctgagga 7380 tgatgtggaa gccaaacgtt tgcggagcac tggaggacga agcggtaaag gaaggtataa 7440 aagccatttg caagagaaat ccgatttctt atgaagagag tatcaaatgg agcttagagc 7500 aatttgatat aatatttaat agataacaat tctcaattag gaggtggaaa agatgagaaa 7560 actcgctttg gcgctcgcac tcttcagcgg ttttggactc ggggcaagcg agaagggaaa 7620 ctccgaggat atgaagctcc ttgagatggc aaagcagtat ttcaagcccc ttccaaaggt 7680 agcggaaaat cccgttacgc cccgagaggt taagctcggg aagatgcttt actacgaccc 7740 gagactctca aagagcggac tgataagctg taatacctgc cacaaccttg cgagatacgg 7800 agttgataac cttccgacct caatagggca caggtgggca ataggaccca gaaacgcacc 7860 caccgtttac aacgcagcca tacacatagc ccagttctgg gacggaaggg ctaaggacgt 7920 ggaagaacaa gccctcggac ccatagtaaa ccccatagag atggcaaaca ccgaggaaaa 7980 cgttgtaaaa accctgaaat caattcccga atacgttgag ctcttcaaga aggcattccc 8040 caacgagaag gaccccgtta aatacgtaaa cataggaaag gcaataggtg cctttgagag 8100 aacgctcatg acaccctcag gatttgacga gttcctgaaa ggaaataccg atgccctcac 8160 cgaacaggaa aagaggggac tcaaaacctt catagaggtg ggatgtgcgg gatgccacaa 8220 cggtgcggga gtcggcggac acatgtttgc gaagttcgga gcgataaccg agtactggaa 8280 agcaacctac ccctacgttc ttaaggaaaa gcccaccata aaggttgact tcggtaggtt 8340 cggtgtgaca aagaacgagg cggatatatt cgtatttaag gttccctccc tcaggaacat 8400 agaacacacc tacccctact tccacgacgg aagcgtatgg agcttagaag atgcggtcag 8460 gataatggct aaaacccagc tcgggaaaga gcttacggac cagcaagtta aggatatcgt 8520 tgccttcctg aaggcactca cgggagaaat acccaagcac gctttagaag ttcctgaact 8580 tcctccttca agggaaaaca ctcccaagcc ccagttctaa gtcctcttcc tttttcccct 8640 taaatttttt tgccttttta aacccttaat aatattagtc atacaaaact tgacataaat 8700 ttactaaatt tttataataa agagagaaaa aaaggaggtg ataaaatggc ggaaaagaaa 8760 gaaaaaataa tcggtataga cctcggaacg acgaactcag tcgtagcggt tatgatggga 8820 gatgaggcgg ttgtaattca gaaccaagaa ggttcaaggc ttaccccctc agtcgtctcc 8880 tggactaagg aaaaggaggt tctcgtagga gaccccgcaa agagaagggc tatccttgac 8940 cccgaaaata cggtatacga gagtaaaagg tttataggga ggaagtttga agaggtaaag 9000 gaagaggcaa aaagagtttc ctacaaggta gttcccgacg agaagggaga cgcagccttt 9060 gatataccca atgctggaaa gctcgtaaga cccgaggagg tgggagctca cgtcctcaga 9120 aagctaaagg aagcagcgga agccttttta ggtgagcccg taaagaaggc ggtaataacc 9180 gttcccgcat acttcaacga gagacaaaga caggcaacaa aggacgcggg aaagattgca 9240 ggtcttgagg tagtgaggat acttaacgag ccgaccgctg ccgcaatggc ttacggactc 9300 cacaagaagg aaaacgtaag gatacttgtt tatgacttcg gtggcggaac ctttgacgtc 9360 tcaatacttg aaggcggaga cggtgttata gaggttaagg cgaccgcggg agatacccac 9420 ctcggtggag ctaacataga cgagaggata atggaatggc tcattgaaga gttcaaaaag 9480 gaacacggca tagacctcag gcaggacaga accgtactcc aaaggctgaa ggaagcagcg 9540 gaacaggcta agaaggagct ttccttcaag atggagaccg agataaacct acccttcata 9600 acgatagacc ccaatacgaa ccagcccctt cacctccaaa agaagctaac aagggcaaga 9660 cttgaggaaa tgataaatga cctcatagac aggaccatag acatagtcaa acaagctctt 9720 gaagatgcta agctaaagcc ctcggatata gacgaagtgg ttctcgtcgg aggttcaacg 9780 agaatacccc tcgttcaaca aaagattaag gaattcttcg gaaaggaacc ccacaaggga 9840 ttaaatcccg acgaagttgt cgcaatggga gcggcaatac aggcgggcgt ccttgcggga 9900 gaagtaaagg aaattgttct cgtagacgta acaccgctat ccttgggagt agagacctac 9960 ggaggcgtta tgaccgttct tatacccagg aacacaccca tacccgtaag gaagtgcgag 10020 gtattcacga cagcccacga ctaccagacc gaggttgaga tacacgtcct ccagggagag 10080 agacccctcg caaaggataa caaatccctt gcaaagttct atcttacggg aatacctccc 10140 gcaccgagag gcgttccaaa aatagaggtt tgctttgaca tagacgcgga cggaatactc 10200 cacgttacag ctaaggacct cggaacgggt aaagagcagt ccgtaagagt agagatatcc 10260 tcgggactca caccagaaga gatagaaagg ataataaaag aggcggaaga gcacgcggaa 10320 gaagacagga agaagaagga gctcatagag gctaagaacc agcttgacca cctcgtttac 10380 cagcttgaaa agaccctaaa agaagcgggg gataaagttc ccgcggatgt aaagcaggaa 10440 gcggaaaagg ttattgaaga ggcgaagaaa accatagaaa ccgcaacgga tataaacgaa 10500 gtcaaaagag ttacagaaag agttctccag gtatcctcaa agctcggaac aaccctttac 10560 ggggaagcgg gtaagaccga gaagaaggac gaaggcggag agggagaggt agaggcaaaa 10620 cccgttgatt aatccccctc ccctccctat acttcttttt taatgaacga agacgtatta 10680 agaattatca aagaacccgt tatcgtcttt tttatcctgg tttgccttcc tatacttaat 10740 cgcttcagta tttttaccaa agaggttttc ctttctggat ttcctccctt ggaacaacct 10800 acttctggct gaaatacgga atggataagc ttaagaagaa acccgatgag gttgataggt 10860 tggttgagaa aggagaggat gaaagtgtaa gagagctttc tatgcttatt cttaaagagc 10920 tttgtgtgcc tttttatttc cgcttccctg cttcccagaa ggatgggaag gggcttcttt 10980 ctaaagcccc ttaagaagtc ttctttttcc tttttcggct ttgccatatc aacgagagga 11040 tgcccgacgt agtgaacctt aaggttttta aaatttctgt aaattttttt ctcaaagggg 11100 agtattacaa ttaggtggtc cgaaagcttc cctattattc gggctctctt tggcttccac 11160 gcccaaacct ggggggatat gaagtagata accttattta cgcctaattt tctcgcatct 11220 tttaagagct tgaggtttaa agcgggtgca tcgcaaagga ttaaggtatc cgccctctga 11280 acgcttttaa gaattcttcc atatagtttt aaaaacttcg gtatcctcgt tagggcttcc 11340 gttataccta ccgccgagat ttcctcatac cttcctacgc tttttatccc tatctcttca 11400 agtctctggt ctgtgagccc ccatatctcg tattcctcaa agccctccct gaatatctcg 11460 taaacgtagt ttgaggctga gcggtccgcg agggagataa aaaccctctt cacttctttg 11520 agagctcttc aatccttgcg gtaatcatat caataatctc ttcaaatata cccttaattt 11580 cttccgccat ggctacgagc ttctcgttcc cgttcttgta agccttatct atgtaaggct 11640 ttacgttcgt ctcgtaatac tccttatact caaaaaggtc atacttcagc tcgtcttctt 11700 caagctcgtc aacaattgcc tcatactcca tcttccttat ccttgcggat gtaaggaggt 11760 ttttaagctc catctcaagg gttcccttat cctttcctgc atttctcggg tcagctggca 11820 tagggaagtt taatataacc taactaaatt aaaatccgat gattaggggc atttacgttc 11880 acataccctt ctgcacatat aagtgtcctt actgcgactt catgtccgtc gtaaactccg 11940 agataagcca cgaagattat ataaaagccc tgaagaagga gataaacttc tacaagggat 12000 taaagggaga agttgaaacc ctttacttcg gagggggaac gccctcactc cttgagccaa 12060 aacaccttga agaggtgata aaagaaattg ataagaactt taactttagg ccttctgaga 12120 taacgattga gtgcaatccc gagacttttg aaagggaaaa gttcagggaa tttaagaatc 12180 tcgggattga cagggtaagc gtaggagtcc agagctttac cgataagggt ttaaaagccc 12240 tcgggagaaa gcacacgctg agggatgttt acaccttcct tgagggggtt tttgagctcg 12300 gttatgagaa cgtaaacgtt gacttaatat ggggctaccc ttcccagact ccaaaagacg 12360 cggaaaagga actgagggag cttgagaagt tcccgataaa acacgtttcc gcatacctcc 12420 tcacctttta tgaaggacac accgatgggc ttttccacag gaggggagag atttcgcctc 12480 ccgaggagga taccatcgta aagattcacg atactctctc cgagggattg agagacctcg 12540 gctttgagag atacgagata tccaactggg caaagagggg atacgagtgc aggcataacc 12600 ttctttactg ggagcttgag gagtttctcg gtttcggtgt atccgcctgg ggcttttaca 12660 aagggagaag atacggaaac acgaggaacc tatacaaa 12698 // |
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