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EBI Dbfetch

ID   AY057452; SV 2; linear; genomic DNA; STD; PRO; 12215 BP.
XX
AC   AY057452;
XX
DT   05-NOV-2001 (Rel. 69, Created)
DT   16-APR-2005 (Rel. 83, Last updated, Version 6)
XX
DE   Edwardsiella ictaluri isolate 93-146 O antigen biosynthesis gene cluster,
DE   partial sequence; and IS1-like insertion sequence, complete sequence.
XX
KW   .
XX
OS   Edwardsiella ictaluri
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Edwardsiella.
XX
RN   [1]
RP   1-12215
RX   DOI; 10.1099/mic.0.26138-0
RX   PUBMED; 12777482.
RA   Lawrence M.L., Banes M.M., Azadi P., Reeks B.Y.;
RT   "The Edwardsiella ictaluri O polysaccharide biosynthesis gene cluster and
RT   the role of O polysaccharide in resistance to normal catfish serum and
RT   catfish neutrophils";
RL   Microbiology (Reading, Engl.) 149(Pt 6):1409-1421(2003).
XX
RN   [2]
RP   1-12215
RA   Lawrence M.L., Banes M.M.;
RT   ;
RL   Submitted (26-SEP-2001) to the EMBL/GenBank/DDBJ databases.
RL   Veterinary Basic Sciences, Mississippi State University, P.O. Box 6100,
RL   Mississippi State, MS 39762-6100, USA
XX
RN   [3]
RC   Sequence update by submitter
RP   1-12215
RA   Lawrence M.L., Banes M.M.;
RT   ;
RL   Submitted (05-MAR-2002) to the EMBL/GenBank/DDBJ databases.
RL   Veterinary Basic Sciences, Mississippi State University, P.O. Box 6100,
RL   Mississippi State, MS 39762-6100, USA
XX
CC   On Mar 5, 2002 this sequence version replaced gi:16648654.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..12215
FT                   /organism="Edwardsiella ictaluri"
FT                   /isolate="93-146"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:67780"
FT   gene            <1..1204
FT                   /gene="dcuC"
FT   CDS             <1..1204
FT                   /codon_start=2
FT                   /transl_table=11
FT                   /gene="dcuC"
FT                   /product="C4-dicarboxylate anaerobic carrier"
FT                   /db_xref="GOA:Q937Y3"
FT                   /db_xref="InterPro:IPR018385"
FT                   /db_xref="UniProtKB/TrEMBL:Q937Y3"
FT                   /protein_id="AAL25626.1"
FT                   /translation="STGWRATDIVEYVKVLLMSRGGDLGMMIMMLCGFAAYMTHIGAND
FT                   MVVKLASRPLRYINSPYILMIAAYFVACLMSLAVSSATGLGVLLMATLFPVMVNVGISR
FT                   GAAAAICASPAAIILAPTSGDVVLAAKASEMPLIDFAFKTTLPISIIAIVCMAIAHYFW
FT                   QRYLDNKEQAQHEILDVNEITTTAPSFYAILPFTPIIGVLVFDGKWGPHLHIISVLVIC
FT                   MLLASVTEFLRSFDAKKVYSGLEVAYRGMADAFASVVMLLVAAGVFAQGLSTVGFISSL
FT                   IELAQSFGTGGIIMMLVLVVITMLAAMTTGSGNAPFYAFVELIPKLSGQMGINPAYLTI
FT                   PMLQASNLGRTLSPVSGVVVAVSGMAKISPFEVVKRTSVPVLVGLVVVIVATEFMVPLH
FT                   R"
FT   repeat_region   2079..2746
FT                   /mobile_element="insertion sequence:IS1-like"
FT   gene            2079..2312
FT                   /gene="insA"
FT                   /note="similar to InsA protein"
FT   gene            2354..2746
FT                   /gene="insB"
FT                   /note="similar to InsB protein"
FT   gene            2984..4231
FT                   /gene="wzx"
FT   CDS             2984..4231
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="wzx"
FT                   /product="O antigen transporter"
FT                   /db_xref="GOA:Q937Y2"
FT                   /db_xref="InterPro:IPR002797"
FT                   /db_xref="UniProtKB/TrEMBL:Q937Y2"
FT                   /protein_id="AAL25627.1"
FT                   /translation="MSSLLKNSISLLAMQGINYILPLVTLPYLTRVLHVYPFGIYSATM
FT                   SVGAYVILFINFGFDLSATRKIAKNKGDNYAISAIFFNVILAKFLLFFLSLVIVFLLLY
FT                   TIDSFYPIRSLFFLLIPQFIGCVFFPAWLYQGVERLYLISAITSATKLLIIPLFFLFVR
FT                   DAGDIDKAIIISGFPLFFSGIIGFYLAYKLNIINFSDVRVRVNDAILLIKESTSVFIGA
FT                   VAISIYTACTPIILSIVSNYTEVGYFSAVDKLRSAILGMFIVLGQVFYPRATVLFESNF
FT                   SKYKLFIRRIIFSQIIFGGVGTILFYFFMPIIAPFILGRGFHGLTELIEIMAPMILLIP
FT                   LSVIFSNCILLPMGKSKLFYIAPIITAIIHLPYSIYLSEKYGAFGGGVSILITEVLSLM
FT                   LLVFFSYKYANLKSIF"
FT   gene            4791..5954
FT                   /gene="wbeiA"
FT   CDS             4791..5954
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="wbeiA"
FT                   /product="WbeiA"
FT                   /db_xref="UniProtKB/TrEMBL:Q937Y1"
FT                   /inference="non-experimental evidence, no additional
FT                   details recorded"
FT                   /protein_id="AAL25628.1"
FT                   /translation="MFPTKEFKYFDFFCVIEGLFKVLLSKLSVNRSVNLLFFYLFFSVF
FT                   VLIFIFKPPFHFFLLNALFIHVYSLVALIFSFFYRVKRKYIIIFFIFLFPLSYLTIMDR
FT                   VTAAYPLVVALFSLLIISDKFQFHNYSCRNLTHFILISTVLFSFLFLYESHIDRYSLVN
FT                   GDPNYTSLILLTVLLISFVFSVSNKLKVLVLLLMLFVVYLTKSRTAILALAAFFLCCKI
FT                   KRKLLLFYFILFVSIASQYFFSYIFPSILSDLDFGHSRFFDLNDASNMERITIYKEAVD
FT                   FILSHFTHFIINGVTNYLEINKLATNIPHNWFIQFILGFGFLFSIYYLAVVVFVAKIVS
FT                   GKSYYLLAFMCFFFVYASFLSYYSLATPLLFLVLSLFVCHSIERVAR"
FT   gene            6029..6814
FT                   /gene="wbeiB"
FT   CDS             6029..6814
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="wbeiB"
FT                   /product="putative glycosyltransferase"
FT                   /note="includes previous wbeiC gene, whose presence was
FT                   annotated because of an error in the sequence"
FT                   /db_xref="GOA:Q937Y0"
FT                   /db_xref="InterPro:IPR002654"
FT                   /db_xref="UniProtKB/TrEMBL:Q937Y0"
FT                   /protein_id="AAL25629.2"
FT                   /translation="MKTFIISLKDEVARRNSISDRLHHHDFEFFDAVDLRVASDDVLSA
FT                   VKCKNINYKHPAIREHMTKGEIGCALSHMQLYKKIVDDNLAFARVIEDDAVILNHDEKI
FT                   LNDFILALEMKNIDWDIMLLGYSKLKACDSFGFYLKEPIKNIVKSGAYSLGIPFRNWTC
FT                   GTVGYLVSQSGAKKMINNAAFGKVCTVADDWLFFEKNYNLKILHIRPLIVLEDFESYES
FT                   SIETDRKTYVNHESHISFFLRVMRGVVRKVYLSISWKSL"
FT   gene            6811..7911
FT                   /gene="wbeiM"
FT   CDS             6811..7911
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="wbeiM"
FT                   /product="putative glycosyltransferase"
FT                   /db_xref="GOA:Q937X8"
FT                   /db_xref="InterPro:IPR001296"
FT                   /db_xref="UniProtKB/TrEMBL:Q937X8"
FT                   /protein_id="AAL25631.1"
FT                   /translation="MKILYVITGLGLGGAEKQLSLLADNFTARGEQVSIVYLTGEVLVK
FT                   PKNKNIKIYNLGIDKSFSSLIKGIWKLKSIISDVRPDVIHSHMYHANILARISCCLSLF
FT                   SSRLVCSAHNKNEGGRVRMIIYRMTDFLCAKTTNVSQEALDEFITKKAFRKRKSSLVYN
FT                   GIDLSIFKKKSTNIQNIKNKLGINFDEKVIFCAGRLTEAKDYPNLILAISKMHQKKCKI
FT                   IIAGDGPMRSDIERLIDRCHLSHRILLIGIIDNISDYYNLSDLFVLPSRWEGFGLVVAE
FT                   AMACECPVIATDAGGVAEVLSNADWLVPIADSSKLAEKIDEFFLLDSSEVKDIKAKNKD
FT                   HCENQFSIGAIINNWYAIYNGIRSKL"
FT   gene            7913..8950
FT                   /gene="wbeiH"
FT   CDS             7913..8950
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="wbeiH"
FT                   /product="putative glycosyltransferase"
FT                   /db_xref="GOA:Q937X7"
FT                   /db_xref="InterPro:IPR001296"
FT                   /db_xref="UniProtKB/TrEMBL:Q937X7"
FT                   /protein_id="AAL25632.1"
FT                   /translation="MKKIFFVITKSEIGGAQKWIVELSNILKEQYEIFIITSGDGWLTS
FT                   KFDSSHVILYPGLLNLKSIFCFFKLANIFRKYKADIVISSSANAGVYARLSKFLYSHKS
FT                   IYVSHGWSCLYNGGRLKKIQCLVERFLSLISDKILCVSENDMNNAIKFIGIKEKKLFVI
FT                   RNGVSPLKKKNVINVRKKVLFVGRMIHPKRPDLFVAVADSFPDVDFYLVGDGPLKQRLE
FT                   TSCQHNNVYFLGEINGFDSFQCYDIFVLCSDSEGLPMSALEAASSGVPILLSDVGGCSE
FT                   LITLMNNGCSNGELFSNDISSLRCKLGAVLLEYDKYFSSAQVVSGCFDINNLAEKYIEL
FT                   IEGDK"
FT   gene            8947..9918
FT                   /gene="wbeiT"
FT   CDS             8947..9918
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="wbeiT"
FT                   /product="UDP-glucose 4-epimerase"
FT                   /db_xref="GOA:Q937X6"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q937X6"
FT                   /protein_id="AAL25633.1"
FT                   /translation="MKLAIIGGSGFIGTRLATQLKNNNVEFTIVDKRNSETFPECWQYG
FT                   DVTKPESLEEPLKGADVIINLAAEHKDNVHPISLYYDVNVQGAKNVCDVAEKLNIQHIV
FT                   FTSSVAVYGFVEKETGEDGKYNPFNDYGKSKLEAEFAYDAWQAKVPERTLVTVRPTVVF
FT                   GENNRGNVYNLFRQIASGKFLMIGPGLNQKSMAYVENMAAFLRFSTTMGAGRHVFNYID
FT                   KPDFSMNDLTGVICTALHRHKNNIRIPYAVGLLGGYCFDILAKVTGREFPVSSIRVKKF
FT                   CARTQFKSNHIAQTGFKAPVTLEQGIANTVRYEFLEKHDDKS"
FT   gene            9905..10807
FT                   /gene="galF"
FT   CDS             9905..10807
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="galF"
FT                   /product="UTP-glucose-1-phosphate uridylyltransferase"
FT                   /db_xref="GOA:Q937X5"
FT                   /db_xref="InterPro:IPR005835"
FT                   /db_xref="UniProtKB/TrEMBL:Q937X5"
FT                   /protein_id="AAL25634.1"
FT                   /translation="MTSLKAVIPVAGLGMKMLPATKAIPKEMLPIVDKPLIQKVVHECL
FT                   SAGVKEIILVTHSSKNTIENHFDTSFELEALLEARVKRQLLDEVRSICPPGVTINSVRQ
FT                   HRQLGLGHAILCARPLVGEHPFIVALPDIWLDASTFDPETQNLAAMVRRFEESGRSQVL
FT                   VQPMPLEALPEYSVINCADAVLEPGQSACMTSIVEKPEDAEKYHSDLSAVGRYVLSAAI
FT                   WPILAATGFGAWERIQLSDAIATLLQHRPVEAYRQVGLSYDCGDKLGYAEAFVAGGLNH
FT                   SQQGAAFTAWLQDVQTRIE"
FT   gene            10823..11839
FT                   /gene="galE"
FT   CDS             10823..11839
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="galE"
FT                   /product="UDP-galactose 4-epimerase"
FT                   /db_xref="GOA:Q937X4"
FT                   /db_xref="HSSP:1XEL"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q937X4"
FT                   /protein_id="AAL25635.1"
FT                   /translation="MAILVTGGAGYIGSHTVLALLSRGDEVVVLDNFVNASVQALARVE
FT                   QICDRQPHLYRGDVRDRALLQQIFAQHVISDVIHFAGLKAVGESVEKPLEYYDNNVSGT
FT                   LVLLEEMRRAGVQGFIFSSSATVYGDPESVPLTESSRTGGTTNPYGTSKLMVEQILQDV
FT                   SRARPEMRITALRYFNPVGAHPSGLIGEDPNGIPNNLIPYVAQVAVGKLACLSIFGHDY
FT                   PTQDGTGVRDYIHVMDLATGHLAALDRRDEGASYKVYNLGTGVGYSVLDIVAAFERCSG
FT                   VTIPYRFAPRRAGDIAECWSNPALAAQELGWCAQYGLEAMMTDTWRWQQNNPNGYQD"
FT   gene            11863..>12215
FT                   /gene="ugd"
FT   CDS             11863..>12215
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="ugd"
FT                   /product="UDP-glucose 6-dehydrogenase"
FT                   /db_xref="GOA:Q937X3"
FT                   /db_xref="HSSP:1DLJ"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q937X3"
FT                   /protein_id="AAL25636.1"
FT                   /translation="MKIAISGTGYVGLSNGILLAQHHEVVALDIVAEKVGMLNRRQSPI
FT                   VDKEIQEYLTNRSLNFRATLDKEEAYRGADFVIIATPTDYDPKSNYFNTASVEAVIRDV
FT                   LAINPAAVMIIKST"
XX
SQ   Sequence 12215 BP; 3225 A; 2206 C; 2867 G; 3917 T; 0 other;
     gtcgaccggc tggcgcgcga ccgatatcgt tgagtatgta aaagttctgc tgatgagtcg        60
     cggcggcgac ctcggcatga tgatcatgat gctgtgcggt tttgccgcct atatgaccca       120
     tatcggtgcc aacgatatgg tggtcaagct ggcctcccgc ccgctgcgct atattaactc       180
     gccctatatt ttaatgattg cggcctactt tgtcgcctgc ctgatgtcgc tggccgtttc       240
     gtcggccacc gggctgggag tattgctgat ggcaaccctg ttcccggtga tggtcaacgt       300
     ggggatcagc cggggggcgg cggcggcgat ctgtgcctcg cctgcggcga tcatcctggc       360
     tccgacctcc ggcgatgtgg tgctggcagc caaggcgtcc gaaatgccgc tgatcgactt       420
     tgcctttaaa acaaccctgc ccatctccat catcgctatc gtctgtatgg cgattgccca       480
     ctacttctgg cagcgctacc tggacaacaa ggagcaggcg cagcacgaga tactggacgt       540
     caacgagatc accaccacgg caccctcgtt ttatgccatt ctgcccttta cgccgatcat       600
     cggcgtgctg gtgttcgacg gtaagtgggg gccacatctg cacatcatca gcgtcctggt       660
     tatctgtatg ctgctggcct cggtgactga gtttttgcgc agcttcgacg ctaaaaaggt       720
     ctatagcggg ctggaggtgg cctaccgcgg gatggcggac gcctttgcca gcgtggtgat       780
     gctgttggtg gccgccgggg tctttgccca ggggctgagc accgtcggct ttatcagcag       840
     cctgatcgag ctggcccagt cctttggcac cggtggcatc atcatgatgc tggtgctggt       900
     ggtgatcacc atgctggcgg cgatgaccac cggctccggc aacgcgccgt tctacgcctt       960
     tgtcgagttg atccccaagc tgtccggcca gatgggcatc aacccggcct acctgaccat      1020
     tccgatgctg caggcctcca atctgggccg caccctatcg ccggtttccg gtgtggtggt      1080
     ggctgtctcc gggatggcca agatctcccc ctttgaggtg gttaaacgca cctcggtgcc      1140
     ggtgctggtc ggcctggtgg tggtgatcgt cgccaccgag tttatggtac cgctgcaccg      1200
     ctgacaaatg caagcgatat acacggagag ggcaggccag aggcctgcct tttttggttt      1260
     gcggtggcaa gtgccagcca tgtggaaatg acatgtcgat aggctggttt tatgttactt      1320
     ttacgccttg gtggcggcag atgcagatgc agatattggt tatatacaca gggtgatata      1380
     caataatcgg aaagataaat tgtatgataa ttggccgtcg gagtttgaaa ataaaaattt      1440
     gagatgtttt accttttttc tattaagtat aaaaattagt gctgcttgtg tccactggtg      1500
     agagtgagcc gtggggaaat ctcacagccg tactgcgtta tgatgggctt gtttgcatgc      1560
     cgtgtcttgt ttttcaagga atatattgac agtgtggcat agatgtaaac acagtaaaaa      1620
     gttgctcagg gtagtcagtg cattggtagc tgtagagcca agggcggtag cgtaagaata      1680
     gcaatccttt tttaaccagt cgcctgtcac tatttgtttt tttagatgtt aacttctatt      1740
     tttatattta tgtaaaaaac ttctgataaa taaattaact aacaatttaa aatgactgtg      1800
     gtttaatatg caagatgatt gtaaggctgc ccattattta ttcaaaataa ataataatat      1860
     gtacagtggg taactccttc aattagatcc attccagtag gaatatatta ttgcacccag      1920
     tttagaccgg acagcgcgta acaaccggag cgtaaacgca gtacgtgagg attgtcagtt      1980
     cggcccagga ccaaaatggc aaatcaaata gcctaatggg atagagtctt agctgatatc      2040
     ggtgtataat tcccgctgtt gaggttgtct catggccagt gttaacgctc actgctccca      2100
     ttttcagtct gctcaggttt acaaccttta agggctgtga ccgggtccgc tgtcgtgatt      2160
     ggtaccctat attcctgctc tcttatacct atgaagcccg taagctcgga gttaaagagc      2220
     aaattactga aatggtattc aacggatccg atgtccggga tacaataaga acatccaaaa      2280
     tcggcattaa caccgtcatt attcgcactt aaaaaaacgc acgccgaggc gaataacatc      2340
     atccctgttg ctcatgaaga tgtggcgctt atctgcgaac tcgatgggca atagcgtttc      2400
     gtcggaatca aaacccgaca acactggttt tggtatgcat acaacaccac aacagatggc      2460
     gttctggtgt tataggtttg gaccacgtac ttatgatata ttccgtgagc tgctgattct      2520
     gcttacatcg tttaatctcg gcatgatagc cagcgatgac tgggtccgtt atgccagaga      2580
     attcccgaaa gagatgcctc tgatcggtaa aatatttact cagcggattg tgcataataa      2640
     tctgatactt tgcacccgca ttcagcggct gaatcgtaaa acaagctcag ctaagattaa      2700
     cgggaaaagc attggtacct tcatagaaaa atatatgttc tactaattgg atgcatcacc      2760
     gttggtgtgt tgattggtga agtggatcca atttttcatt aatatggaag agaattcata      2820
     tgttttttgt tctcaatagg tgggttgtta tttgttgatg ataaggccga ggtctatata      2880
     ttatttaatt taataaggaa gttgctttgt aaaataataa aaatattggt attgaggata      2940
     agttttgatg gctggaagca ttgttaaaat ataatggtat attatgagtt cacttctaaa      3000
     aaattccata tctttacttg caatgcaagg gattaactac atactaccac tagtaacgct      3060
     accttacttg actagagttc tgcatgtata tccatttggt atatatagtg caacgatgag      3120
     tgttggcgct tatgtaatat tgttcataaa ttttggtttt gatcttagtg cgacgaggaa      3180
     aatcgcaaaa aacaagggtg ataattatgc tattagcgcc atatttttta atgttatctt      3240
     ggctaagttt ttgttatttt ttctctcgct tgttatcgtg tttttattgc tttatacgat      3300
     tgattcattt tatcctatta ggtctttatt ctttttatta atacctcagt ttattggctg      3360
     tgtttttttt cctgcttggt tatatcaagg ggtggagcgg ttatatctaa tatcagcaat      3420
     aacatctgcc acaaagctat taattattcc tctgtttttt ttatttgtaa gagatgctgg      3480
     tgatattgat aaagctataa ttatctctgg tttcccgctg ttcttttctg gtatcattgg      3540
     tttttatcta gcatataagt taaatatcat caacttttca gatgtgaggg taagggttaa      3600
     tgatgctatt cttttgataa aagaatctac ttctgttttt attggggctg tggctataag      3660
     tatatatacg gcatgtactc caattatttt aagcattgtt agtaattata ctgaggtcgg      3720
     ctatttttca gcagtagata aattaagaag tgctatttta ggtatgttta ttgtgctagg      3780
     tcaggttttt tatccaagag ctactgtttt gtttgaaagt aatttttcaa aatataagct      3840
     atttataagg cgaattattt tttcgcagat tatttttggc ggggttggga cgatattatt      3900
     ttatttcttc atgccaatca ttgcgccatt tattttaggg cgtggttttc atgggttgac      3960
     agagctcatt gaaataatgg ccccaatgat attattaatt cctttgtctg taatattctc      4020
     taattgcatt ctactgccaa tggggaagag taaattgttt tatattgctc ccataataac      4080
     agctataata catttgccat actctattta tttgagtgaa aagtatggcg cttttggtgg      4140
     cggggtctcg atattaataa ctgaggtcct tagtttaatg ttgttagtgt ttttttctta      4200
     taaatacgca aatttgaaaa gcattttttg aagtgagagg attacataag gcacatgttg      4260
     ttttatggat tggagagtca attaggtgag ggctatatat aattataggc tttgttgaat      4320
     catgctgttt gcagtgttga ggggagggtt caagaagaca tatttctcta cacgctctaa      4380
     ccacatgatt tttcgtcact agggttggcc actatattga gataacagca taaaatagac      4440
     ttatacaaca acgcttaagc cacatgtaat aacaaacaaa tggtttgggg aatataacta      4500
     tgaacatccg tataaactcc tgaataacct gactctagag gagttttgga tgacgaatac      4560
     aagcgacgga agcctaaagg aattatgaaa ctaaagctgg cgtttttgca gtaggctatt      4620
     taataggaat gtatgcagct aaattaatga tagaaaatga taagccatca atctttagtg      4680
     attgtatact tcatgtgtat gatattaata gtaaaatatt acacatgtta tccatgtatg      4740
     attttagagg gttgttaaag gatgtgtaat tgtattaaag gtgatgggga atgtttccta      4800
     caaaagagtt taagtatttt gacttttttt gtgtaataga gggattgttc aaagtgttgc      4860
     tctcaaaatt gtccgttaat cgtagtgtga atcttttgtt tttttatttg tttttttctg      4920
     tctttgtgtt gatatttata ttcaagcctc cgtttcattt ttttttgcta aacgcattat      4980
     ttattcatgt atattcactg gttgctttga ttttctcttt tttctataga gtaaagcgaa      5040
     aatatatcat catctttttt atttttttat tcccattaag ttatttgact attatggaca      5100
     gagttactgc tgcatatccg cttgtggtgg ctcttttttc attattaatc atctctgata      5160
     agtttcagtt tcataattac tcctgtcgca atttaacgca ctttatttta atttctactg      5220
     ttcttttttc atttttattt ctgtatgaat cacacatcga tcgttattcg ttagttaatg      5280
     gcgatcctaa ctataccagt ttgatcttat taactgtgct acttatttct tttgtatttt      5340
     ctgtgagtaa taagcttaaa gtgttagttt tattattaat gctttttgtt gtttatttga      5400
     caaaatcaag aacggcaata ttggctttgg ctgcattttt tctatgttgt aagattaagc      5460
     ggaaattatt gttgttctat tttatattat ttgtgtctat agcctctcag tatttctttt      5520
     catacatatt cccttcaata ctgtctgatc tcgatttcgg ccatagccga ttttttgatt      5580
     taaatgatgc cagtaatatg gaaaggataa ctatttataa ggaggccgtg gattttatat      5640
     tatcccattt tactcacttt attattaatg gggtgactaa ttatttagaa ataaacaagt      5700
     tggctactaa tataccacat aattggttta tccagtttat tcttgggttt gggtttttat      5760
     tttctattta ttatttggcg gtggttgttt ttgttgcaaa aatagtttct ggtaagtctt      5820
     attatctatt ggcttttatg tgttttttct ttgtttatgc atcatttctc agttattatt      5880
     ctttagcaac tccattatta tttttggtgt tatctctatt cgtgtgccat agtattgaaa      5940
     gagtggcgag ataatgaatg ttgttttatg tcgattgcgt tataatattg agtgttttac      6000
     atccacatta taagaatcca ttgaacctat gaaaactttt attatatcct tgaaagatga      6060
     agtcgctcgt agaaatagca ttagcgatag gttacatcat catgacttcg agttttttga      6120
     tgcggttgat ttgagagtgg catcagatga tgtgctttca gcggtaaaat gtaaaaatat      6180
     taattataaa catccagcaa ttagagagca tatgacaaaa ggagagattg gatgtgcttt      6240
     aagtcatatg cagctatata aaaaaattgt tgatgataat ttagcatttg ctagagtaat      6300
     tgaagatgat gcggttattt taaatcatga tgaaaagatt cttaatgatt tcatattggc      6360
     tttggaaatg aagaatatag actgggatat catgttgctg ggatattcta agttaaaagc      6420
     atgtgattct tttggttttt atcttaagga gccaattaaa aatatcgtaa agagcggtgc      6480
     atactcttta ggaataccat ttaggaactg gacttgtgga acggtaggat atctggtttc      6540
     tcaaagtggt gcaaagaaaa tgattaataa tgctgccttt ggtaaggtat gcactgttgc      6600
     tgatgattgg cttttttttg aaaaaaatta taatttaaaa atacttcata taagacctct      6660
     aattgtattg gaggactttg agtcgtatga aagttcaata gagacagata gaaaaactta      6720
     tgttaatcat gaatcacata tctcattctt tttaagagtt atgagagggg ttgtaaggaa      6780
     agtatattta tctatctctt ggaaaagttt atgaaaatac tatatgttat tacagggtta      6840
     gggttgggtg gggcagagaa acaactttct ttattagcag ataattttac tgctagaggt      6900
     gagcaagttt caatcgttta tttaaccgga gaggtactgg ttaagccgaa aaacaaaaat      6960
     ataaaaatat ataatctagg tatagataaa agtttttctt cactaatcaa ggggatctgg      7020
     aaactaaaat caataatatc tgacgttagg cctgatgtga tccattcgca tatgtatcat      7080
     gctaatatct tagctcgtat ttcatgttgc ctttccctat tttcatctag gttagtgtgc      7140
     tcggctcata ataaaaacga gggggggcga gttaggatga ttatttatcg aatgactgat      7200
     tttctatgtg ctaaaacaac aaatgttagt caggaagctc tggatgagtt tataactaag      7260
     aaagcattta gaaaaagaaa gtctagttta gtctataatg gaatagatct ttctatcttt      7320
     aaaaagaaaa gcactaatat tcaaaatatt aaaaataaat taggaataaa ttttgatgag      7380
     aaggtgatat tttgtgcagg tagattaaca gaagcaaaag actatcctaa tttgatcctc      7440
     gcaatatcta agatgcacca gaaaaaatgt aagattatca ttgctggtga tggtcccatg      7500
     cgtagtgata tagagagact aattgatcgt tgccatctat cgcatcggat tttacttatt      7560
     gggataattg ataatatttc tgattactat aatttatctg atctatttgt attgccatct      7620
     cgctgggagg gttttgggtt agttgtcgca gaggctatgg catgtgaatg cccagtgata      7680
     gcaactgatg cagggggtgt tgctgaggtt ctttctaatg ctgattggct ggttccaatt      7740
     gctgatagca gtaaattagc tgagaaaatt gatgagtttt ttttgcttga ctcttcagaa      7800
     gttaaagata tcaaagcgaa aaacaaagac cattgtgaga accaattttc cattggggct      7860
     ataattaata attggtatgc catttataat gggataagat cgaaattata atatgaaaaa      7920
     aatatttttt gtaattacaa aatcagagat tggcggtgcg caaaagtgga ttgttgagct      7980
     atccaatatt ttaaaagaac aatatgaaat tttcattatt acatctggag atggatggct      8040
     aacatcaaaa tttgattcat ctcacgtcat tctttaccca gggttattga atcttaagag      8100
     tattttttgt ttttttaaat tggctaatat atttcggaaa tataaagctg atatcgttat      8160
     ttcaagctct gcaaatgctg gggtttatgc gaggttatct aaattcctat attctcataa      8220
     aagcatttat gtttcccatg gatggtcttg tctttataat ggcggaagat taaaaaagat      8280
     acagtgcttg gttgaaagat ttctatcatt aatttcagat aaaatactat gtgtttctga      8340
     gaatgatatg aataatgcta taaaatttat agggataaaa gaaaaaaaat tatttgtcat      8400
     tagaaatggt gttagccccc tgaaaaaaaa gaatgttatt aatgtgagaa agaaagtcct      8460
     ctttgttgga agaatgattc atcccaaaag acccgatttg ttcgtcgctg tagcagacag      8520
     ttttcctgat gtggattttt atctggtagg tgatggtcct ctaaaacaaa ggttagagac      8580
     atcctgtcaa cataataatg tttattttct tggcgagatt aatgggtttg acagttttca      8640
     gtgctatgat atttttgtac tttgttctga tagtgaaggt ttacctatgt cagcattgga      8700
     agccgcttct tctggggtgc ctattttatt aagtgatgta ggtggttgtt ctgaactaat      8760
     tactttaatg aataatggat gtagtaatgg cgagttattt tctaatgata tatcttcgtt      8820
     aagatgtaag ttaggtgctg ttttgcttga atatgataaa tatttttcat ctgctcaggt      8880
     tgtaagcggt tgctttgata taaacaatct tgctgaaaaa tatattgaat taattgaggg      8940
     tgataaatga aattagcaat cattggcggt tctggtttta tcggtacgcg tctggctacg      9000
     cagttaaaaa ataataatgt tgaatttact attgttgata aacgaaacag cgaaacgttt      9060
     ccggagtgtt ggcaatatgg agatgttact aagcctgaat cacttgaaga accattgaaa      9120
     ggcgcagatg tcatcattaa tctcgccgca gagcacaaag ataatgtcca tccaatcagc      9180
     ctttactatg atgtaaatgt ccaaggtgct aaaaatgttt gtgatgtcgc tgaaaagcta      9240
     aacatacaac atattgtatt tacttcatca gttgcagttt atggttttgt ggaaaaagaa      9300
     accggagaag atgggaagta taatcctttc aatgattatg gtaagtcaaa attagaggct      9360
     gagtttgcgt atgatgcctg gcaagcgaaa gtaccagaga gaacattggt aacagtcaga      9420
     ccaaccgttg tcttcggtga aaataatcgc gggaacgtat ataacttatt ccgccagata      9480
     gcatcaggta agtttttgat gattggccca gggctgaatc aaaaatcaat ggcgtatgtt      9540
     gaaaatatgg ccgccttctt gaggttttcg accacgatgg gagcggggcg tcatgttttt      9600
     aactatatag ataaaccaga ctttagtatg aatgatttaa ctggggtgat ttgtacagca      9660
     ttacatcgcc ataaaaacaa tattcgtatt ccttatgcgg ttggcctgtt aggtggctat      9720
     tgcttcgata tcctggcaaa ggttaccggt cgagagttcc ccgtaagcag cattcgtgtg      9780
     aagaagtttt gtgctcgtac tcagtttaag tcaaaccata tcgcgcaaac gggatttaaa      9840
     gcgccggtaa cgttagagca gggtatcgcc aatacggttc gttacgagtt tttggagaag      9900
     catgatgaca agtcttaaag ccgttatccc cgtcgccgga ctggggatga agatgttgcc      9960
     ggccaccaag gccatcccga aagagatgct gcccattgtt gataagccgc tgattcagaa     10020
     agttgtccat gagtgtttgt ccgccggggt gaaagagatc atcctggtca cccattcatc     10080
     caagaatacc attgagaacc acttcgatac ttcctttgag ctggaagcgc tgctcgaggc     10140
     gcgcgttaag cgccagttgc tggatgaggt acgttccatc tgccctcccg gggtgacgat     10200
     taacagcgtg cgtcagcata ggcagctggg tctgggacat gccattcttt gtgcccgtcc     10260
     tctggtggga gaacatcctt ttatcgtcgc gctgccggat atctggttag atgccagtac     10320
     cttcgatcct gaaacccaga atctggcagc gatggtcagg cgctttgagg agagcgggcg     10380
     cagccaggtg ctggtgcagc cgatgccgct ggaggctttg ccggagtatt cggtgattaa     10440
     ctgtgccgat gcggtgctgg aaccggggca gagtgcgtgt atgacctcga ttgtcgaaaa     10500
     acctgaggat gcggaaaagt accactccga tctgtcggcg gtcgggcgct acgtcttgtc     10560
     ggccgccatc tggccgattt tagctgccac cggctttggc gcctgggagc gcatccagct     10620
     ctccgacgct attgcaaccc tgttgcagca ccgtccggtc gaggcctacc gtcaggtggg     10680
     gctatcctat gactgtggcg ataaattggg gtatgctgag gcctttgtcg ccggtgggtt     10740
     aaatcactct cagcagggag cggcctttac cgcctggctg caggatgtgc agacgcgaat     10800
     tgaatgattc agggtattta gcatggcaat tttagtgacc ggcggcgccg gctatatcgg     10860
     ttctcatacg gtgctggcgc tgctgtcccg tggggatgag gtggtagtgc tggataactt     10920
     tgtcaacgcc tctgtgcagg cgctggcccg ggtggagcag atttgtgacc gccaacccca     10980
     cctataccgc ggtgatgtgc gcgatcgggc gctgctgcag cagatttttg cacagcacgt     11040
     cattagcgat gtgattcact tcgccggtct aaaggccgtg ggtgagtcgg tggaaaaacc     11100
     gcttgagtac tacgacaaca atgtcagcgg tacgctggtg ttgctggaag agatgcgccg     11160
     cgccggcgtg cagggcttta tctttagctc ctcggcgacg gtgtatggcg atccggagtc     11220
     agtgccgttg acggaaagca gccgtaccgg cgggacgacc aacccctatg gcacctccaa     11280
     gctgatggtc gagcagatcc tgcaggatgt atcccgcgct agacctgaga tgcggattac     11340
     cgcgctgcgc tactttaatc cggtgggagc tcatccatcg gggcttatcg gtgaagatcc     11400
     caacgggata cccaataatc tgatccctta tgttgctcag gtggcggtgg gaaaactggc     11460
     ctgcctgtcc atctttggcc atgattatcc cacacaggac ggcaccgggg tacgcgacta     11520
     tattcacgtg atggatctgg ccaccggcca ccttgccgca ctcgatcgtc gcgatgaggg     11580
     ggccagctat aaagtgtata acctggggac gggcgtcggg tattctgttt tggatatcgt     11640
     tgccgcattt gagaggtgct ccggggttac tataccttat cgctttgcac cgcgccgcgc     11700
     gggtgatatc gccgagtgtt ggtccaatcc cgccttggcg gcgcaagagt tgggttggtg     11760
     tgcgcagtat ggtctggagg cgatgatgac cgatacctgg cgctggcagc agaacaaccc     11820
     gaatggatac caggattaat tttattaaca caaaggtatg tgatgaagat agcgattagc     11880
     ggtacgggct acgtcggcct gtccaatgga attttgctgg ctcagcatca tgaggtggtg     11940
     gcgctggata ttgtggcgga aaaggtcggg atgcttaacc ggcgtcagtc accgatcgtg     12000
     gataaggaga tccaggagta cctcactaac cgctccctga atttccgcgc gacgctggac     12060
     aaggaagagg cgtaccgcgg cgctgatttt gtcattatcg cgacgccgac cgactatgat     12120
     cccaagagta attactttaa caccgccagc gtagaggcgg tgatccgcga tgtgctggcg     12180
     attaacccgg cggcggtgat gatcatcaag tcgac                                12215
//


  
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