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EBI DbfetchID AL583921; SV 1; linear; genomic DNA; STD; PRO; 332450 BP. XX AC AL583921; XX DT 20-FEB-2001 (Rel. 66, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 3) XX DE Mycobacterium leprae strain TN complete genome; segment 5/10 XX KW . XX OS Mycobacterium leprae OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium. XX RN [1] RP 1-332450 RX DOI; 10.1038/35059006 RX PUBMED; 11234002. RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., RA Wheeler P.R., Honore N., Ganier T., Churcher C., Harris D., Mungall K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., RA Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., RA Jagels K., Lacroix C., Maclean J., Moule S., Murphy L., Oliver, Quail M.A., RA Rajandream M-A., Rutherford K.M., Rutter S., Seeger K., Simon S., RA Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., RA Whitehead S., Woodward J.R., Barrell B.G.; RT "Massive gene decay in the leprosy bacillus"; RL Nature 409(6823):1007-1011(2001). XX RN [2] RP 1-332450 RA Parkhill J.; RT ; RL Submitted (20-FEB-2001) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium leprae sequencing teams, The RL Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, RL UK Unitie de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du RL Docteur Rouux, 75724, Paris Cedex, France. E-mail: parkhill@sanger.ac.uk XX DR EMBL-CON; AL450380. DR RFAM; RF00005; tRNA. XX CC Notes: CC CC Details of M. leprae sequencing at the Sanger Centre CC are available from http://www.sanger.ac.uk/Projects/M_leprae/ CC A relational datbase containing the M. leprae sequences is available from CC http://genolist.pasteur.fr/Leproma/ XX FH Key Location/Qualifiers FH FT source 1..332450 FT /organism="Mycobacterium leprae" FT /strain="TN" FT /mol_type="genomic DNA" FT /db_xref="taxon:1769" FT CDS 100..1269 FT /pseudo FT /transl_table=11 FT /gene="ML1153" FT /product="probable oxidoreductase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv0063 (Best blastx score 343)" FT CDS complement(1323..2552) FT /pseudo FT /transl_table=11 FT /gene="ML1154" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1318c (Best blastx score 336)" FT misc_feature 2959..3618 FT /note="Pfam match to entry PF01939 DUF91, Protein of FT unknown function, score 445.00, E-value 6.6e-130" FT CDS 2959..3621 FT /transl_table=11 FT /gene="ML1155" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein SW:YD21_MYCLE (P53524) (201 aa); Fasta FT score E(): 0, 99.5% identity in 193 aa overlap. Also highly FT similar to Mycobacterium tuberculosis hypothetical protein FT Rv1321 SW:YD21_MYCTU (Q10634) (226 aa); Fasta score E(): 0, FT 88.2% identity in 220 aa overlap. Contains Pfam match to FT entry PF01939 DUF91, Protein of unknown function." FT /db_xref="InterPro:IPR002793" FT /db_xref="UniProtKB/Swiss-Prot:P53524" FT /protein_id="CAC31536.1" FT /translation="MIAQCTVDYLGRLTAHLPSARRLLLFKADGSVSVHADDRAYKPLN FT WMSPPCWLTEDVAGASPAWVVENKAGEQLRITVEEVEHDSCHDLGVDPGLVKDGVEAHL FT QTLLAEQVQLLGEGYTLVRCEYMTAIGPVDLLCRDEQGGSVAVEIKRRGEIDGVEQLTR FT YLALLNRNSVLAPVRGVFAAQHIKPQARTLATDRGIRCVTLDYDKMRGMDSDEYRLF" FT CDS 3645..3928 FT /pseudo FT /transl_table=11 FT /gene="ML1156" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1322 (Best blastx score 222)" FT CDS complement(3953..4420) FT /transl_table=11 FT /gene="ML1157" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49717 (EMBL:U00014) (155 aa); Fasta score E(): FT 0, 99.4% identity in 155 aa overlap. Also similar to FT Streptomyces coelicolor conserved hypothetical protein FT TR:CAB70628 (EMBL:AL137242) (146 aa); Fasta score E(): FT 1.5e-19, 42.1% identity in 140 aa overlap and Haemophilus FT influenzae lactoylglutathione lyase (EC 4.4.1.5) FT SW:LGUL_HAEIN (P44638) (135 aa); Fasta score E(): 0.69, FT 27.5% identity in 138 aa overlap. Contains Pfam match to FT entry PF01626 4HPPD_C, 4-hydroxyphenylpyruvate dioxygenase FT C terminal domain." FT /db_xref="HSSP:1JC5" FT /db_xref="InterPro:IPR004360" FT /db_xref="UniProtKB/TrEMBL:Q49717" FT /protein_id="CAC31538.1" FT /translation="MMTTDQINTCQLLATTLVITIDHVGIAVADLNAAISWYHDHLGMI FT LVHEEVNDDQGIREAMLSAHGAPIGTTQIQLMAPINESSPIAKFLDKHGPGIQQLACRV FT SDLDRLTKRLRAQGVRLVYDTPRQGTSNARINFIHPKDAGGVLIELVEPAS" FT misc_feature complement(3962..4420) FT /note="Pfam match to entry PF01626 4HPPD_C, FT 4-hydroxyphenylpyruvate dioxygenase C terminal domain, FT score 179.90, E-value 4e-50" FT misc_feature 4512..5690 FT /note="Pfam match to entry PF00108 thiolase, Thiolase, FT score 760.80, E-value 5.8e-225" FT CDS 4512..5693 FT /transl_table=11 FT /gene="fadA4" FT /gene_synonym="ML1158" FT /product="possible acetyl-CoA C-acetyltransferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable acetyl-CoA acetyltransferase (EC 2.3.1.9) FT SW:THIL_MYCLE (P46707) (393 aa); Fasta score E(): 0, 100.0% FT identity in 393 aa overlap. Also highly similar to many FT others including: acetyl-CoA acetyltransferases from FT Alcaligenes eutrophus SW:THIL_ALCEU (P14611) (393 aa); FT Fasta score E(): 0, 50.4% identity in 389 aa overlap and FT Mycobacterium tuberculosis (FadA4) Rv1323 SW:THIL_MYCTU FT (Q10629) (389 aa); Fasta score E(): 0, 86.9% identity in FT 388 aa overlap. Contains Pfam match to entry PF00108 FT thiolase, Thiolase. Contains PS00098 Thiolases acyl-enzyme FT intermediate signature. Contains PS00099 Thiolases active FT site. Contains PS00737 Thiolases signature 2." FT /note="ML2162" FT /db_xref="GOA:P46707" FT /db_xref="HSSP:1PXT" FT /db_xref="InterPro:IPR016038" FT /db_xref="UniProtKB/Swiss-Prot:P46707" FT /protein_id="CAC31539.1" FT /translation="MTTSVIVTGARTPIGKLMGSLKDFSASDLGAITIAAALKKANVAP FT SIVQYVIIGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGLDAIALADQLIRA FT GEFDVVVAGGQESMTKAPHLLMDSRSGYKYGDVTIVDHLAYDGLHDVFTNQPMGALTEQ FT RNDVEKFTRQEQDEFAARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQFTEDEGIRA FT NTSAESLAGLKPAFRCGGTITPGSASQISDGAATVVVMNKEKAQQLGLTWLVEIGAHGV FT VAGPDSTLQSQPANAIKKAVDREGISVEQLDVVEINEAFAAVALASARELGIAPELVNV FT NGGAIAVGHPLGMSGARITLHVALELARRGSGYGVAALCGAGGQGDALILRAV" FT misc_feature 4761..4817 FT /note="PS00098 Thiolases acyl-enzyme intermediate FT signature" FT misc_feature 5526..5576 FT /note="PS00737 Thiolases signature 2" FT misc_feature 5631..5672 FT /note="PS00099 Thiolases active site" FT CDS 5880..6785 FT /transl_table=11 FT /gene="ML1159" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae TR:Q49716 FT (EMBL:U00014) (255 aa); Fasta score E(): 0, 100.0% identity FT in 217 aa overlap. Highly similar to Mycobacterium FT tuberculosis Rv1324 SW:YD24_MYCTU (Q10636) (304 aa); Fasta FT score E(): 0, 72.4% identity in 301 aa overlap. Also weakly FT similar in parts to several putative thioredoxins e.g. FT Alicyclobacillus acidocaldarius SW:THIO_ALIAC (P80579) (105 FT aa); Fasta score E(): 0.00045, 27.1% identity in 107 aa FT overlap." FT /db_xref="GOA:Q9CC76" FT /db_xref="HSSP:1THX" FT /db_xref="InterPro:IPR013766" FT /db_xref="UniProtKB/TrEMBL:Q9CC76" FT /protein_id="CAC31540.1" FT /translation="MAGAVDLSGLKQRARQKASTSDPASRATLGARGTGSSENTSVIEI FT TEANFEDEVLVRSHEVPILVLVWSPRSDACVKLLETLSGLAVADSGTWLLATVNVDAVP FT RVAQIFGVDAVPTVVALAAGQPLSSFQGMQSVDQLRRWLDSLLSVTAGKLRGPTRSEDS FT AEIDPAIAQARQQLEAGDFLTAKQSYHAILDADPASVEAKAAIRQIDFLTRATAQHPDA FT VAVADAAPGDIAAAFAAADVQILNQDVTAAFERLIVLVRSTSGDERSSVRTRLIELFEL FT FDPDDPNVIVGRRNLANALY" FT CDS complement(6841..9018) FT /pseudo FT /transl_table=11 FT /gene="ML1160" FT /product="1,4-[alpha]-glucan branching enzyme (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT glgB (Best blastx score 959)" FT CDS complement(9044..11140) FT /pseudo FT /transl_table=11 FT /gene="ML1161" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1327c (Best blastx score 650)" FT CDS 11692..13890 FT /pseudo FT /transl_table=11 FT /gene="ML1162" FT /product="possible glycogen phosphorylase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT glgP (Best blastx score 579)" FT CDS complement(14861..15685) FT /pseudo FT /transl_table=11 FT /gene="ML1163" FT /product="possible antibiotic efflux protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3239c (Best blastx score 223)" FT CDS complement(15666..16106) FT /pseudo FT /transl_table=11 FT /gene="ML1164" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1330c (Best blastx score 280)" FT CDS 16212..16538 FT /transl_table=11 FT /gene="ML1165" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein SW:YD31_MYCLE (P53423) (94 aa); Fasta FT score E(): 0, 98.9% identity in 94 aa overlap. Also highly FT similar to proteins of undefined function from FT Mycobacterium tuberculosis Rv1331 SW:YD31_MYCTU (Q10642) FT (101 aa); Fasta score E(): 0, 84.2% identity in 101 aa FT overlap and Streptomyces coelicolor TR:Q9S2G5 FT (EMBL:AL096852) (105 aa); Fasta score E(): 1.4e-20, 56.7% FT identity in 104 aa overlap." FT /db_xref="GOA:P53423" FT /db_xref="HSSP:1MBX" FT /db_xref="InterPro:IPR014719" FT /db_xref="UniProtKB/Swiss-Prot:P53423" FT /protein_id="CAC31546.1" FT /translation="MWVMVVTLAPIEPKVRPNTTWQHESAPVDITAARWVTIVWDDPVN FT LMAYVTYVFQKLFGYSEPHATKLMLQVHNEGKAVVSMGSRESMEVDVSKLHAAGLWATM FT QQDR" FT RBS 16554..16557 FT CDS 16564..17151 FT /transl_table=11 FT /gene="ML1166" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein SW:YD32_MYCLE (P53424) (222 aa); Fasta FT score E(): 0, 100.0% identity in 195 aa overlap. Also FT highly similar to proteins of undefined function from FT Mycobacterium tuberculosis Rv1332 SW:YD32_MYCTU (Q10643) FT (218 aa); Fasta score E(): 0, 74.4% identity in 195 aa FT overlap and Streptomyces coelicolor TR:Q9S2G6 FT (EMBL:AL096852) (202 aa); Fasta score E(): 1.5e-05, 34.6% FT identity in 188 aa overlap." FT /db_xref="InterPro:IPR018561" FT /db_xref="UniProtKB/Swiss-Prot:P53424" FT /protein_id="CAC31547.1" FT /translation="MRKWKRVETANGPRFRSVVAPHEVALLKHLVGALLGLLNERESSS FT PLDELEVITGIKAGNAQRPEDPTLRRLLPDFYTPDDKDQLDPAALDAVDSLNAALRSLH FT EPEIVDAKRSAAQQLLDTLPESDGRLELTEASANAWIAAVNDLRLALGVILEIDRPAPE FT RVPAGHPLSVHFDVYQWLTVLQEYLVLALMAT" FT CDS 17151..18239 FT /transl_table=11 FT /gene="ML1167" FT /product="possible hydrolase" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein SW:YD33_MYCLE (P53425) (362 aa); Fasta FT score E(): 0, 100.0% identity in 362 aa overlap. Similar to FT Flavobacterium sp. TR:Q57326 (EMBL:D26094) (355 aa); Fasta FT score E(): 1.4e-11, 31.6% identity in 351 aa overlap FT endo-type 6-aminohexanoate oligomer hydrolase. Also similar FT to proteins of undefined function from Mycobacterium FT tuberculosis Rv1333 TR:YD33_MYCTU and Streptomyces FT coelicolor TR:CAB90977 (EMBL:AL355832) (348 aa); Fasta FT score E(): 0, 48.2% identity in 365 aa overlap." FT /db_xref="GOA:P53425" FT /db_xref="HSSP:1B65" FT /db_xref="InterPro:IPR005321" FT /db_xref="UniProtKB/Swiss-Prot:P53425" FT /protein_id="CAC31548.1" FT /translation="MILMAAPMNSITDISGIQVGHYHRLDPDASLGAGWACGVTVVLTP FT PGTVGAVDCRGGVPGTRETDLLDPANSVRFVDAVLLAGGSAYGLAAADGVMRWLEEHER FT GVVMLGGVVPIVPGAVIFDLSVGDFHCRPTAEFGYLACQAAYDAAVGGQDATVAVGTVG FT AGVGARAGVLKGGVGTASITLESGPTVGAVVVVNSVGDVVDRATGLPWMTDLIDEFALR FT PPSPEQIAGFAQLKSPLSALNTTIGVVATDATLSPAACQRVAMAAQDGLARTIRPAHTA FT LDGDTVFALATGAVEATATADVPVAMSPETGLITEVGAAADDCLARAVLVAVLAAESVA FT GIPTYCGMFPGAFGTTIGGGNR" FT CDS 18232..18595 FT /pseudo FT /transl_table=11 FT /gene="ML1168" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1334 (Best blastx score 127)" FT CDS 18734..18990 FT /pseudo FT /transl_table=11 FT /gene="ML1169" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1335. Highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1335 9.5 KDa antigenic protein FT SW:CF10_MYCTU." FT CDS 19011..19997 FT /pseudo FT /transl_table=11 FT /gene="cysM" FT /gene_synonym="ML1170" FT /product="cysteine synthase B (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT cysM (Rv1336) (Best blastx score 302)" FT RBS 20077..20088 FT CDS 20092..20808 FT /transl_table=11 FT /gene="ML1171" FT /product="possible conserved integral membrane protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta FT score E(): 0, 100.0% identity in 238 aa overlap. Also FT highly similar to other proteins of undefined function e.g. FT Mycobacterium tuberculosis hypothetical protein Rv1337 FT SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% FT identity in 231 aa overlap. Contains possible membrane FT spanning hydrophobic domains. Contains Pfam match to entry FT PF01694 Rhomboid, Rhomboid family." FT /db_xref="GOA:P53426" FT /db_xref="InterPro:IPR002610" FT /db_xref="UniProtKB/Swiss-Prot:P53426" FT /protein_id="CAC31552.1" FT /translation="MGAPSACGGGSALMTLPEKNLGYKPETETNRRLRWMVGGVTILTF FT MALLYLVELIDQLTRHSLDNNGIRLLKTDVLWGISFAPVLHANWQHLVANTIPLLVLGF FT LIALAGLSRFIWVTAMVWIFGGSATWLIGNMGSSFGPTDHIGVSGLIFGWLAFLLVFGL FT FVRRGWDIIGCMVLFAYGGVLLGVMPVLGRCGGVSWQGHLCGAISGVVAAYLLSAPERK FT TRALKEAGTDSPRLKT" FT misc_feature 20299..20754 FT /note="Pfam match to entry PF01694 Rhomboid, Rhomboid FT family, score 158.10, E-value 1.6e-43" FT CDS 20805..21623 FT /transl_table=11 FT /gene="murI" FT /gene_synonym="ML1172" FT /product="glutamate racemase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable glutamate racemase (EC 5.1.1.3) FT SW:MURI_MYCLE (P46705) (272 aa); Fasta score E(): 0, 100.0% FT identity in 272 aa overlap. Also highly similar to many FT others involved in peptidoglycan biosynthesis including FT glutamate racemases from Mycobacterium tuberculosis Rv1338 FT SW:MURI_MYCTU (Q10626) (271 aa); Fasta score E(): 0, 88.9% FT identity in 271 aa overlap and Bacillus subtilis FT SW:MURI_BACSU (P94556) (272 aa); Fasta score E(): 0, 42.2% FT identity in 268 aa overlap. Contains Pfam match to entry FT PF01177 Asp_Glu_race, Aspartate / glutamate racemase. FT Contains PS00924 Aspartate and glutamate racemases FT signature 2. Contains PS00923 Aspartate and glutamate FT racemases signature 1." FT /db_xref="GOA:P46705" FT /db_xref="HSSP:1B74" FT /db_xref="InterPro:IPR004391" FT /db_xref="UniProtKB/Swiss-Prot:P46705" FT /protein_id="CAC31553.1" FT /translation="MSSPLLPVGVFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYG FT PLSIPEIRAHALAICDDLVGRGVKILVIACNTASAACLRDARERYDVPVVEVILPAVRR FT AVAATRNGRIGVIGTRATIASHAYQDAFAAARDTEITAVACPRFVDFVECGVTSGRQVL FT GLAEGYLEPLQRSGVDTLVLGCTHYPLLAGLIQLAMGENVTLVSSAEETAKEVLRVLTE FT RDLLRRHDAPPVNRVFEATGDPEAFIQLAARFLGPAVSGVQPARLHSRVR" FT misc_feature 20826..21467 FT /note="Pfam match to entry PF01177 Asp_Glu_race, Aspartate FT / glutamate racemase, score 396.40, E-value 2.8e-115" FT misc_feature 21018..21044 FT /note="PS00923 Aspartate and glutamate racemases signature FT 1" FT misc_feature 21345..21377 FT /note="PS00924 Aspartate and glutamate racemases signature FT 2" FT CDS 21696..22478 FT /transl_table=11 FT /gene="ML1173" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta FT score E(): 0, 100.0% identity in 260 aa overlap. Also FT highly similar to several other proteins of unknown FT function e.g. Mycobacterium tuberculosis Rv1339 FT SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 FT (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% FT identity in 256 aa overlap." FT /db_xref="UniProtKB/Swiss-Prot:P50474" FT /protein_id="CAC31554.1" FT /translation="MTVRITVLGCSGSVVGPDSPASGYLLRAPDTPPLVLDFGGGVLGA FT LQRHADPGSVHVLLSHLHADHCLDMPGLFVWRRYHPTRPVGKALLYGPDDTWLRLGAAS FT SPYGGEIDDCSDIFDVRHWVDGEPVPLGALMIMPRLVAHPTESYGLRITDPSGASLVYS FT GDTGSCDQLVELARGADVFLCEASWTHSPDRPPNLHLSGTEAGRAAAQASVRELLLTHI FT PPWTSREDVISEAKAEFDGPVHAVVSGETFDIQAPERV" FT CDS 22568..23347 FT /transl_table=11 FT /gene="rphA" FT /gene_synonym="ML1174" FT /product="ribonuclease PH" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable ribonuclease PH (EC 2.7.7.56) SW:RNPH_MYCLE FT (P37939) (259 aa); Fasta score E(): 0, 99.6% identity in FT 259 aa overlap. Also highly similar to many other FT ribonucleases including: Mycobacterium tuberculosis FT SW:RNPH_MYCTU (Q10628) (259 aa); Fasta score E(): 0, 88.8% FT identity in 259 aa overlap and Escherichia coli FT SW:RNPH_ECOLI (P03842) (238 aa); Fasta score E(): 0, 55.7% FT identity in 237 aa overlap. Contains Pfam match to entry FT PF01138 RNase_PH, 3' exoribonuclease family. Contains FT PS01277 Ribonuclease PH signature." FT /db_xref="GOA:P37939" FT /db_xref="InterPro:IPR002381" FT /db_xref="UniProtKB/Swiss-Prot:P37939" FT /protein_id="CAC31555.1" FT /translation="MSTRADGRLDDELRAVVITRGFTEHPAGSVLIEFGHTKVMCTASP FT TEGVPRWRKGSGKGWLTAEYAMLPSATHTRSERESVKGRLSGRTQEISRLIGRSLRACI FT DLAALGENTIAVDCDVLQADGGTRTAAVTGAYVALADAVTYLSAAGRLLDPRPLSCAIA FT AVSVGVVDGRIRVDLSYEEDSRAEVDMNVIATDTGTLVEIQGTGEGATFPRSTLDKLLD FT MALGACDKLFVAQRDALALPYQGMSPEGPPPPKAFGS" FT misc_feature 22577..23248 FT /note="Pfam match to entry PF01138 RNase_PH, 3' FT exoribonuclease family, score 286.30, E-value 3.9e-82" FT misc_feature 22919..22957 FT /note="PS01277 Ribonuclease PH signature" FT CDS 23382..24044 FT /transl_table=11 FT /gene="ML1175" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein TR:Q9S383 (EMBL:AL049191) (220 aa); FT Fasta score E(): 0, 99.5% identity in 220 aa overlap. Also FT highly similar to many other proteins of undefined function FT including: Mycobacterium tuberculosis Rv1341 SW:YD41_MYCTU FT (Q10649) (204 aa); Fasta score E(): 0, 82.4% identity in FT 205 aa overlap and Escherichia coli SW:YGGV_ECOLI (P52061) FT (197 aa); Fasta score E(): 1e-23, 44.8% identity in 203 aa FT overlap. Contains Pfam match to entry PF01725 Ham1p_like, FT Ham1 family." FT /db_xref="GOA:P52063" FT /db_xref="InterPro:IPR002637" FT /db_xref="UniProtKB/Swiss-Prot:P52063" FT /protein_id="CAC31556.1" FT /translation="MGVSPSREAARGVALVTKLLVASRNWKKLAELRRVLDNAGLSGLT FT LVSLNDVVPFDEAPEAGATFEDNALAKARDAFAATGLASVADDSGLEAAALGGMPGVLS FT ARWSGSYGDDAGNTALLLAQLCDVPDERRSAAFVSACALVSESDEVVVRGVWPGTIARE FT PRGYGGFGYDSIFIPDGPGLGGRTVAQLRPAEKDAFSHRFRALTLLMPALRVLAMRT" FT misc_feature 23436..24020 FT /note="Pfam match to entry PF01725 Ham1p_like, Ham1 family, FT score 337.60, E-value 1.4e-97" FT CDS complement(24085..24444) FT /transl_table=11 FT /gene="ML1176" FT /product="possible conserved membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein SW:YD42_MYCLE (P54133) (119 FT aa); Fasta score E(): 0, 100.0% identity in 119 aa overlap. FT Also highly similar to hypothetical proteins from FT Mycobacterium tuberculosis Rv1342c TR:YD42_MYCTU and FT Streptomyces coelicolor TR:Q9X948 (EMBL:AJ237976) (109 aa); FT Fasta score E(): 7.7e-11, 36.5% identity in 96 aa overlap. FT Contains possible membrane spanning hydrophobic domains." FT /db_xref="GOA:P54133" FT /db_xref="UniProtKB/Swiss-Prot:P54133" FT /protein_id="CAC31557.1" FT /translation="MTRPETPQAPDFDFEKSRTALLGYRIMAWTTGIWLIALCYEIVSH FT LVFHHEIRWIEVVHGWVYFVYVLTAFNLAIKVRWPIGKTVGVLLAGTVPLLGIIVEHFQ FT TKDVKTRFGLRHSRT" FT CDS complement(24441..24821) FT /transl_table=11 FT /gene="ML1177" FT /product="possible lipoprotein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein SW:YD43_MYCLE (P54134) (126 FT aa); Fasta score E(): 0, 99.2% identity in 126 aa overlap. FT Also highly similar to Mycobacterium tuberculosis Rv1343c FT SW:YD43_MYCTU (Q11013) (126 aa); Fasta score E(): 0, 78.4% FT identity in 125 aa overlap. Contains a possible N-terminal FT signal sequence and an appropriately positioned Prokaryotic FT membrane lipoprotein lipid attachment site. Contains FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site." FT /db_xref="GOA:P54134" FT /db_xref="UniProtKB/Swiss-Prot:P54134" FT /protein_id="CAC31558.1" FT /translation="MSTTRRRRPALVALVTIAACGCLALGWWQWTRFQSASGTFQNLGY FT ALQWPLFAGFCLYTYHNFVRYEESPPQPRHMNCIAEIPPELLPARPKPEQQPPDDPALR FT KYNTYLAELAKQDAENHNRTTT" FT misc_feature complement(24762..24794) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT tRNA 25676..25758 FT /gene="leuW" FT /note="tRNA Leu anticodon TAG, Cove score 55.29" FT CDS 26547..27275 FT /pseudo FT /transl_table=11 FT /gene="ML1178" FT /product="possible 3-oxoacyl-[ACP] reductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fabG2 (Best blastx score 176)" FT CDS 28807..29901 FT /pseudo FT /transl_table=11 FT /gene="ML1179" FT /product="possible acyl-CoA dehydrogenase (pseudogene)" FT repeat_region complement(31873..32751) FT /note="100 % identical to bases 1221223..1222101" FT CDS complement(31900..32187) FT /transl_table=11 FT /gene="ML1180" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49946 (EMBL:U15180) (95 FT aa); Fasta score E(): 0, 100.0% identity in 95 aa overlap. FT Also similar to many Mycobacterium tuberculosis proteins FT with undefined function e.g. RV1793 TR:O53942 FT (EMBL:AL022021) (94 aa); Fasta score E(): 4.3e-23, 65.2% FT identity in 92 aa overlap." FT /db_xref="InterPro:IPR009416" FT /db_xref="UniProtKB/Swiss-Prot:Q49946" FT /protein_id="CAC31561.1" FT /translation="MGNINYQFGEIDAHGAAIRAQAAALETTHQAILATVRDAAEFWGG FT QGSTAHEMFIADLGRNFQMIYEQANSHGQKVQRASSSMADTDRSVSSAWS" FT RBS complement(32198..32203) FT CDS complement(32239..32541) FT /transl_table=11 FT /gene="ML1181" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49945 (EMBL:U15180) (100 FT aa); Fasta score E(): 0, 100.0% identity in 100 aa overlap. FT Also similar to many Mycobacterium tuberculosis proteins FT with undefined function e.g. RV1197 TR:O05299 (EMBL:Z93777) FT (98 aa); Fasta score E(): 1.7e-20, 58.3% identity in 96 aa FT overlap." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:Q49945" FT /protein_id="CAC31562.1" FT /translation="MTAAHFMTDPQAMRDMARKFDMHAQNVRDESHKMFMSSMDIAGAG FT WSGTAQLTSHDTMGQINQAFRHIVTLLQDVRDQLGTAADRYEHQEENSRKILSGS" FT CDS complement(32604..33869) FT /transl_table=11 FT /gene="ML1182" FT /product="PPE-family protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative PPE protein TR:Q9Z5K0 (EMBL:AL049191) (421 FT aa); Fasta score E(): 0, 100.0% identity in 421 aa overlap. FT Also highly similar to many members of the Mycobacterium FT tuberculosis PPE-family of proteins e.g. Rv2892c FT SW:YS92_MYCTU (Q10813) (408 aa); Fasta score E(): 1.2e-25, FT 34.0% identity in 429 aa overlap. Contains Pfam match to FT entry PF00823 PPE, PPE family." FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q9Z5K0" FT /protein_id="CAC31563.1" FT /translation="MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAAAQG FT LQSAVEALLTTFEGESAAALAERVTPYEKWLTQNAASAELTATQLTVAANAYETAFTMT FT VPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYTEMWIQDAAAMTSYQASVLEAVG FT ATKAFTAPPLGVNEVGLAQEVVEEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEA FT TVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANA FT GLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAAS FT IGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTG FT GVNTALRLQPRAFVMPRNPAAG" FT repeat_region 33263..33322 FT /note="5 copies of 12 bp tandem repeat, Consensus FT CCTCAACAACCT " FT repeat_region complement(33370..34438) FT /note="100 % identical to bases 1220160..1221229 (with a 1 FT bp gap)" FT misc_feature complement(33381..33854) FT /note="Pfam match to entry PF00823 PPE, PPE family, score FT 312.90, E-value 3.8e-90" FT CDS complement(33926..34225) FT /transl_table=11 FT /gene="ML1183" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49943 (EMBL:AL049191) (99 FT aa); Fasta score E(): 0, 100.0% identity in 99 aa overlap. FT Also highly similar to many Mycobacterium tuberculosis FT hypothetical proteins e.g. TR:O05297 (EMBL:Z93777) (99 aa); FT Fasta score E(): 1.3e-12, 48.9% identity in 92 aa overlap FT and the N-terminus of several PGRS-family proteins, also FT from M. tuberculosis e.g. RV0742 TR:O53805 (EMBL:AL021958) FT (175 aa); Fasta score E(): 8.8e-09, 39.6% identity in 96 aa FT overlap. Contains Pfam match to entry PF00934 PE, PE FT family." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q49943" FT /protein_id="CAC31564.1" FT /translation="MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTEIAPPAA FT DDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAYAGTETANHDSL" FT misc_feature complement(33941..34222) FT /note="Pfam match to entry PF00934 PE, PE family, score FT 155.60, E-value 8.6e-43" FT CDS complement(35235..36313) FT /pseudo FT /transl_table=11 FT /gene="ML1184" FT /product="zinc-containing alcohol dehydrogenase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT adhD (Best blastx score 217)" FT CDS complement(36439..36927) FT /pseudo FT /transl_table=11 FT /gene="ML1185" FT /product="probable cytochrome p450 (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1777 (Best blastx score 111)" FT CDS complement(38376..38678) FT /transl_table=11 FT /gene="ML1186" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CC71" FT /protein_id="CAC31567.1" FT /translation="MTQKDGSTLIGPAAHESQFLALVEPSLLLANLPFTFTHNSVPLGK FT LGFLLTQPDLPPGDRGFLRAQPGLLFTNLPFPLSDSSAPLCKLDLSVSEPGVPLV" FT CDS complement(39115..40006) FT /pseudo FT /transl_table=11 FT /gene="ML1187" FT /product="acyl-CoA synthase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadD8 (Best blastx score 98)" FT CDS complement(42195..42455) FT /transl_table=11 FT /gene="ML1188" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="GOA:Q9CC70" FT /db_xref="InterPro:IPR000524" FT /db_xref="UniProtKB/TrEMBL:Q9CC70" FT /protein_id="CAC31569.1" FT /translation="MPRQEALVEPLNVSLLSFREALQIMDTERLISLRRGNRGSVVVHT FT PTRTSAAYMLGLLLQSKSIALADLGAALQELEPACAALAAQ" FT CDS complement(44093..44476) FT /transl_table=11 FT /gene="ML1189" FT /product="hypothetical protein" FT /note="unknown function, identical to the previously FT sequenced Mycobacterium leprae hypothetical protein FT TR:Q9X7D8." FT /db_xref="UniProtKB/TrEMBL:Q9X7D8" FT /protein_id="CAC31570.1" FT /translation="MLEKNRPQIFDSFDRILKARSPEAWLSRRKEIDLHSTIFEYTLKL FT TAEKRRNPSDDIWRTLASAVITGNDEKPFRLPANELEFFFVLTFTGSNTAKHTTGYWTA FT GVHHESRPDKTIPRSGSIAPQRR" FT CDS 46891..47610 FT /transl_table=11 FT /gene="ML1190" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q9X7E1 (EMBL:AL049478) (239 FT aa); Fasta score E(): 0, 100.0% identity in 239 aa overlap. FT Also highly similar to Mycobacterium tuberculosis Rv2525c FT TR:P95028 (EMBL:Z83863) (240 aa); Fasta score E(): 0, 82.2% FT identity in 241 aa overlap." FT /db_xref="InterPro:IPR019546" FT /db_xref="UniProtKB/TrEMBL:Q9X7E1" FT /protein_id="CAC31571.1" FT /translation="MSVSRRDVLKFATVTPGLLGLGVAAAALCAVPASTAGSLGTLLDY FT AAGVIPASQIRATGAVGAIRYVSDPRGTWAVGKPIQVTEARDLINNGLKIVSCYQYGKG FT NTADWLGGATAGLRHAQRGVQLHTAAGGPVSAPIYASIDSNPTYEQYKQQVAPYLRSWE FT SVIGHQRTGVYANSRTIAWALQDGLASYFWQHNWGSPKGYTHPAANLHQVEIDRRTVGG FT VGVDVNTILKPQFGQWA" FT CDS 48222..57452 FT /transl_table=11 FT /gene="fas" FT /gene_synonym="ML1191" FT /product="fatty acid synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative type I fatty acid synthase TR:Q9X7E2 FT (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% FT identity in 3076 aa overlap. Also highly similar to many FT other fatty acid synthases including: Mycobacterium FT tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); FT Fasta score E(): 0, 85.8% identity in 3081 aa overlap and FT Corynebacterium ammoniagenes fatty-acid synthase (EC FT 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score FT E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam FT match to entry PF00109 ketoacyl-synt, Beta-ketoacyl FT synthase. Contains Pfam match to entry PF00698 Acyl_transf, FT Acyl transferase domain. Contains Pfam match to entry FT PF01575 MaoC_dehydratas, MaoC like domain. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site. FT Contains PS00606 Beta-ketoacyl synthases active site." FT /db_xref="GOA:Q9X7E2" FT /db_xref="HSSP:1MLA" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9X7E2" FT /protein_id="CAC31572.1" FT /translation="MTIHEHDQVSADRNGNSLHGSRALADRLKAGEPYVVAFGGQGSAW FT LETLEELVSSAGLEADLATLVCEVELLLEPVAKELVVVRPIGFEPLQWVRALLAEDLVP FT SDKHLTSAAVSVPGVLLTQIAVGRALARQGMDLIATPPVGIVGHSQGVLAVEALKAGGA FT RDAELLAMAQLIGAAGTLVARRRGISVLGDRPPMVSVTNADPERIRRLLDEFAQDVRTV FT LPPVLSIRNGWRSVVITGTPEQLSRFERYCRQISDKEEEDRRKKIRGGDIFAPVFDPVQ FT VEIGFHTPHLADGIGIVGGWAEKVGLDVTLARELTEAILVRGVDWVREITRVHGAGVRW FT IIDLGPGDILTRLTAPVIRGLGVGIVPVANRGGQRTLFTVGAVPEVVRAWLSYAPTVVQ FT LPDGRIKLSTKFTRLTGRSPILLAGMTPTTVDANIVAAAANAGHWAELAGGGQVTEEIF FT ANRVEQLSGLLEPGRTYQFNALFLDPYLWKLQVGGKRLVQKARQSGAAIDGVVISGGIL FT DLEDAVELIEELGGIGISYVVFKPGTIEQIRSVIRIATEMSTKPVIMHVEGGRAGGHHS FT WEDLDDLLLATYSELRSHANITVCVGGGIGTPEKAAEYLSGRWAQAYGFPLMPIDGILV FT GTAAMATKEATTSPSVKRMLVETQGTDQWIGSGKAQGGMASSRSQLGADIHEIDNAASR FT CGRLLDEVAGDAEAVAERRDEIIAAMANTAKPYFGDVSEMTYLQWLQRYVELTIGEGNS FT TADTASPGSPWLADTWRDRFQKMLQRAESRLHPSDFGLIKTIFTDPVLLEKPNQAIAAL FT LKYYPDAETVQLHPADAPFFVMLCQMLGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYD FT ADQVCIIPGIAAVAGITQMDEPVGELLDRFEQAAIDEVLAGGAEPVVVMSRRLGRADVA FT GPLAVVLDAPDVLWAGRIATNPVHRIADPNEWQVNGNLSATHSSTGAQLQVKSEDQQVV FT LSVPVSNGWIDIPFTLPTNTVDGGALLVSTEDATSAMRAVLAIVAGVDGPELLSPVKDG FT TAIVTVDWNPERVADHTGVTATFREPLAPSLATVPDALVGACWPAVFSAIGSAVTEAGV FT LVVEGLLNLLHLDHAVCVVGKLPTVPAQLTVTATVSLAIDTDMGRVVPVSVTIRDTTGA FT DGAVLATLEERFVILGRTGTAELTGPVRAGGAISENATDTPRRRRRDVTLTAPIDMRPF FT AVVSGDHNPIHTDRTAALLAGLESPIVHGMWLSAAAQHVVMATDGQARPAARLIGWTAR FT FLGMAHPGDKVDFRVDRIGIDQGAEILEVSARISSGLVMSATARLAAPKTVYAFPGQGI FT QHKGMGMDVRARSKAARRVWDDADKFTRSGLGFSVLHVVRDNPTNITANGVHYHHPDGV FT LYLTQFTQVAMATVAVAQVAEMREQGAFVEGAIACGHSVGEYTALACVMGVYELEALLE FT TVFHRGSKMHDIVLRDELGRSNYRLAAIRPSQIGLPDDEVPAFVRGIAESTGEFLEIVN FT FNLRGSQYAIAGTVHGLEALEAEVERRRELTGGRRSFILVPGIDVPFHSRVLRVGVAEF FT RRSLDRVLPQDQDPDWIIGRYIPNLVPRPFTLARDFIQEIRDLVPAEPLDDILADYDTW FT RRERPSEMARRVLIELLAWQFASPVRWIETQDLLFTEEAAGGLGVERFVEIGVKSAPTV FT AGLATDTLKLPEYSHNTVEVLNVERDAAVLFATDTDPELEPEPENVSDASAALPAESAL FT ALGTVAPAPVVPSGPRPEDISFGAADATLALIALSAKMRLDQIEEMDSIESITDGASSR FT RNQLLVDLGSELSLGAIDGVAEADLAGLRSQVTKLARTYKPYGPVLSELINDQLRSALG FT PSGKRPGVIAERVKKIWELGDGWVKHVTVEIALGTREGTSVRGGPLGNLNEGALADVDS FT VDKAVDAAVASVAARHGVVVALPSAGSGGSATVDVAALSEFTDQITGHDGVLASAARLV FT LGQLGLDGPVTAAPATTDTGLIDLVTAELSTDWPRLVAPVFDVKKAVVFDDRWASARED FT LVRLWLNDEGEIEAQWSHLSERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAG FT AQNPDRGLYSSEIAVVTGASKGSIAASVAARLLDGGATVIATTSKLDEERITFYRALYR FT DHARYGAALWVVAANMASYSDIDALVEWIGNEQTESLGPQSIHIKDAQTPTLLFPFAAP FT RVIGDLSEAGARSEIEMKVLLWAVQRLIVGLSKIGTERDVASRLHVVLPGSPNRGMFGG FT DGAYGEAKSALDAVVSRWHAESSWAARVSLAHALIGWTRGTGLMGHNDVIVSAVEEAGV FT TTYSTDEMAAMLLDLCNAESKVAAAGTPITVDLTGGLGEVDLDMAELAAKAREDHAAQA FT AEDEATEASEVAGTIAALPSPPRGYTPASPHWDDLDVDPADLVVIVGGAEIGPYGSSRT FT RFEMEVAGELSAAGVLELVWTTGLIRWEDDPQPGWYDTESGELVDESELVERYHDTVVQ FT RCGIREFVDDGTIDPDHAYPLLVSVFLDKDFAFVVSSEADARAFVEFDPEHTVIRPVPD FT SSDWQVIRKAGTEIRVPRKMKLSRVVGGQIPTGFDPTVWGISPDMVSSIDRVAVWSIVA FT TVDAFLSAGFTPAEVMRYVHPSLVANTMGTGMGGGTSIQRLYHSSLLGRNKPNDIFQEI FT LPNIVAAHVVQSYIGSYGSMIHPVAACATAAVSVEEGVDKIRLGKAELVVAGGIDDLTL FT EGIIGFGDMAATADTAMMRGRGIHDSKFSRPNDRRRLGFVEAQGGGTILLARGDLALKM FT GLPVFAVVAFAQSFGDGVHTSIPAPGLGALGAGRGGKDSPLVQSLAKLGVSADDIAVIS FT KHDTSTLANDPNETELHERLADAMGRSAGAPLFVVSQKSLTGHAKGGAAVFQMMGLCQM FT LRDGVIPPNRSLDCVDEELAGAAHFVWLRDTLRLGEKFPLKAGMLTSLGFGHVSGLVAL FT VHPQAFIAALDPGQRDDYQRRANVRLLAGQRRLASAIAGGAPMYERPPDRRFDHHVPEK FT LQEAAMLLNPAARLGDGDAYIG" FT misc_feature 51822..52190 FT /note="Pfam match to entry PF01575 MaoC_dehydratas, MaoC FT like domain, score 136.40, E-value 5e-37" FT misc_feature 52221..53102 FT /note="Pfam match to entry PF00698 Acyl_transf, Acyl FT transferase domain, score 19.00, E-value 4.2e-11" FT misc_feature 55884..57215 FT /note="Pfam match to entry PF00109 ketoacyl-synt, FT Beta-ketoacyl synthase, score -125.00, E-value 3.1e-06" FT misc_feature 56373..56423 FT /note="PS00606 Beta-ketoacyl synthases active site" FT CDS 57481..57873 FT /transl_table=11 FT /gene="acpS" FT /gene_synonym="ML1192" FT /product="holo-[acyl-carrier protein] synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae holo-[acyl-carrier protein] synthase (ACP)(EC FT 2.7.8.7) SW:ACPS_MYCLE (Q9X7E3) (130 aa); Fasta score E(): FT 0, 99.2% identity in 130 aa overlap. Also highly similar to FT ACPs from Mycobacterium tuberculosis SW:ACPS_MYCTU (O53228) FT (130 aa); Fasta score E(): 0, 86.7% identity in 128 aa FT overlap and Escherichia coli SW:ACPS_ECOLI (P24224) (125 FT aa); Fasta score E(): 0.00025, 35.1% identity in 131 aa FT overlap. Contains Pfam match to entry PF01648 ACPS, FT 4'-phosphopantetheinyl transferase superfamily." FT /db_xref="GOA:Q9X7E3" FT /db_xref="HSSP:1FTF" FT /db_xref="InterPro:IPR004568" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7E3" FT /protein_id="CAC31573.1" FT /translation="MGIVGVGIDLVSIPDFAEQVSQPGTVFMTIFTPGERRDASVKSSS FT AVCHLAARWAVKEAVIKAWSGSRFAQRPMLPENIHRDIEVVNDMWGRPRVRLTGAIAKH FT LTDVTIHVSLTHEGDIAAAVVILEVL" FT misc_feature 57493..57852 FT /note="Pfam match to entry PF01648 ACPS, FT 4'-phosphopantetheinyl transferase superfamily, score FT 126.70, E-value 4.3e-34" FT CDS 57963..59291 FT /transl_table=11 FT /gene="ML1193" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q9X7E4 (EMBL:AL049478) (442 FT aa); Fasta score E(): 0, 100.0% identity in 442 aa overlap FT and highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2522c TR:O53227 (EMBL:AL021185) (470 FT aa); Fasta score E(): 0, 86.4% identity in 440 aa overlap. FT Contains Pfam match to entry PF01546 Peptidase_M20, FT Peptidase family M20/M25/M40." FT /db_xref="GOA:Q9X7E4" FT /db_xref="InterPro:IPR011650" FT /db_xref="UniProtKB/TrEMBL:Q9X7E4" FT /protein_id="CAC31574.1" FT /translation="MSDLIERVREVLPLVRRDLENLVRIESVWADPGRRNEVHRSAQVV FT LDLLSQAGFNFVRIVSEGGAPAVIARYPAPLGTPTVLLYAHHDVQPEGDRDQWASPPFE FT PTERDGRIYGRGSADDKAGIATHLAAFRAHGGRPPVGVTVFVEGEEESGSPSLGRLLAA FT HRDALAADVIIIADSDNWSTDVPALTVSLRGLVDCVVEVATLDHGLHSGLWGGVVPDAL FT SVLMRLLASLHDDDGNVAVAGLHESTTAADVNYPHERVRADSGLLDGVSEIGSGSVPQR FT LWAKPAITVIGIDTTSVAAASNMLIPRARAKISMRIAPGGDAAVHLDALTAHLQRYAPW FT GAQVSVIRGEVSQPYAIEASGGVYDTARTAFRQAWGADPTDMGMGGSIPFIAEFASAFP FT QAKILVTGVGDPATQAHGVNESVHLGVLERAAVAEALLLANLA" FT misc_feature 58017..59123 FT /note="Pfam match to entry PF01546 Peptidase_M20, Peptidase FT family M20/M25/M40, score 193.20, E-value 1.8e-54" FT repeat_region 59272..60107 FT /note="Dispersed repeat, RLEP, copy 14" FT CDS complement(60407..61672) FT /pseudo FT /transl_table=11 FT /gene="ML1194" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT papA3 (Best blastx score 212)" FT RBS 62376..62380 FT CDS 62385..65564 FT /transl_table=11 FT /gene="ileS" FT /gene_synonym="ML1195" FT /product="isoleucyl-tRNA synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae isoleucyl-tRNA synthetase (EC 6.1.1.5) SW:SYI_MYCLE FT (Q9X7E5) (1059 aa); Fasta score E(): 0, 100.0% identity in FT 1059 aa overlap. Also highly similar to many Prokaryotic FT and Eukaryotic tRNA synthases e.g. Mycobacterium FT tuberculosis RV1536 SW:SYI_MYCTU (Q10765) (1041 aa); Fasta FT score E(): 0, 84.4% identity in 1059 aa overlap and FT Schizosaccharomyces pombe SW:SYIC_SCHPO (O13651) (1064 aa); FT Fasta score E(): 0, 39.5% identity in 1041 aa overlap. FT Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA FT synthetases class I (I, L, M and V). Contains PS00178 FT Aminoacyl-transfer RNA synthetases class-I signature." FT /note="Similar to ML1472 (valyl-tRNA synthase)" FT /db_xref="GOA:Q9X7E5" FT /db_xref="HSSP:1ILE" FT /db_xref="InterPro:IPR013155" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7E5" FT /protein_id="CAC31576.1" FT /translation="MTNSAYPRTDLGADQRGGSPNFPALEAQVLDYWSNDDTFRASIAR FT CDDAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMCGYKVERRFGWDTHGLPAE FT LEVERQLGITDKSQIDAMGIAAFNEACRKSVLRYTEEWQAYVTRQARWVDFDNDYKTLD FT LSYMESVIWAFKQLWDKGLAYESYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTL FT GFKVLGGDDEDLVGAYLLVWTTTPWTLPSNLAVAVHPDVTYVDVRAGDRRFVLAQARLT FT AYARELGDEPEVLATYRGADLLGRHYLPPFQYFYESARNAFQVLPGDFVTTDDGTGIVH FT IAPAYGEDDMATADKVGIVPVTPVDSNGCFDATVPDYQGQHVFEANAQIIRDLKNQSGS FT AAVNGAVLLRHETYEHPYPHCWRCRNPLIYRAVSSWFVAVTEFRDRMVELNQQITWYPE FT HVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPDYPRIDVYGSLDELERDFGVRP FT TNLHRPYIDELTRPNPDDPTGLSTMRRIPDVFDVWFDSGSMPYAQVHYPFENDDWFDGF FT DSADSDKQVDAHYPGDFIVEYIGQARGWFYTLHVLATALFDRPAFKTCIAHGVVLGSNG FT QKMSKSLRNYPDVTEIFDRDGSDAMRWFLMASPILRGGNLIITEPGIREGMRQVLLPLW FT NAYSFLALYAPKIGTWHTDVSHVLDRYILAKLAVLRDDLSQAMEVCDISGACEQLRQFT FT EPLTNWYLRRSRARFWDEDVDAIDTLHTVLEVTARLAAPLLPLITEIIWRSVTGGRSVH FT LTDWPQANQLPADPDLVAVMDQVRQVCSAASSLRKAKKLRVRLPLPKLVVAVYNSQRLK FT PYIDLIGDELNVKQIELTDAIDTYGRFEFTVNARVAGPRLGRDVQAAIKVVKAGEGVAN FT PDGTLTAGPVVLQPDEYSSRLVAANPEFTAELPDGSGLVVLDDTVTPELEAEGWAKDRI FT RELQELRKLIGLDVSDRIRVLMSVPAERADWARVHRDFIAREILATSFEFGEPADSVAI FT GDGVRVSLLKV" FT misc_feature 62466..64586 FT /note="Pfam match to entry PF00133 tRNA-synt_1, tRNA FT synthetases class I (I, L, M and V), score 690.10, E-value FT 1.1e-203" FT misc_feature 62559..62594 FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT CDS complement(65646..66152) FT /pseudo FT /transl_table=11 FT /gene="ML1196" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3832c (Best blastx score 159)" FT CDS 66278..67654 FT /pseudo FT /transl_table=11 FT /gene="dinX" FT /gene_synonym="ML1197" FT /product="probable DNA-damage-inducible protein FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT dinX (Best blastx score 489)" FT CDS complement(67622..68554) FT /transl_table=11 FT /gene="ansA" FT /gene_synonym="ML1198" FT /product="L-asparaginase/L-glutaminase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable L-asparaginase (EC 3.5.1.1) SW:ASPG_MYCLE FT (Q9X7E6) (310 aa); Fasta score E(): 0, 100.0% identity in FT 310 aa overlap. Also highly similar to many other FT L-asparaginases e.g. Mycobacterium tuberculosis Rv1538c FT SW:ASPG_MYCTU (Q10759) (315 aa); Fasta score E(): 0, 72.4% FT identity in 315 aa overlap and Saccharomyces cerevisiae FT SW:ASG1_YEAST (P38986) (381 aa); Fasta score E(): 6.4e-12, FT 27.5% identity in 327 aa overlap. Contains Pfam match to FT entry PF00710 Asparaginase, Asparaginase. Contains PS00917 FT Asparaginase / glutaminase active site signature 2. FT Contains PS00144 Asparaginase / glutaminase active site FT signature 1." FT /db_xref="GOA:Q9X7E6" FT /db_xref="HSSP:1NNS" FT /db_xref="InterPro:IPR006034" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7E6" FT /protein_id="CAC31579.1" FT /translation="MSRLTVIATGGTISTSTDHDGVRRPAYSGTELTAHVAVDVDVVDL FT MTVDSSQLIPTDWDRIRAAVHTATRNGARGVVVTHGTDTMEETALWLDLTYAGNVPVVL FT TGAMRSADAPNADGPTNLREALAVAASPAARGVGVLVSFAGRVLQPLGLRKAATQDLSG FT FAGELLGTSSSGFALTAAKTRPYLGDLCAADAPRVDIVAAYLGSDSVALDAYVSTGARG FT IVLEALGSGNAGAAVVDGVRRHCHNGIVIAVSTRVPEGHVSAGYGPGHDLVEAGAVLVP FT WLRPSQVRVLLMAALAANLPIADVIERWG" FT misc_feature complement(67631..68542) FT /note="Pfam match to entry PF00710 Asparaginase, FT Asparaginase, score 321.20, E-value 1.2e-92" FT misc_feature complement(68300..68332) FT /note="PS00917 Asparaginase / glutaminase active site FT signature 2" FT misc_feature complement(68513..68539) FT /note="PS00144 Asparaginase / glutaminase active site FT signature 1" FT CDS 68629..69234 FT /transl_table=11 FT /gene="lspA" FT /gene_synonym="ML1199" FT /product="lipoprotein signal peptidase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae lipoprotein signal peptidase (EC 3.4.23.36) FT TR:Q9X7E7 (EMBL:AL049478) (201 aa); Fasta score E(): 0, FT 100.0% identity in 201 aa overlap. Also highly similar to FT lipoprotein signal peptidases from: Mycobacterium FT tuberculosis SW:LSPA_MYCTU (Q10764) (202 aa); Fasta score FT E(): 0, 80.6% identity in 201 aa overlap and Bacillus FT subtilis SW:LSPA_BACSU (Q45479) (154 aa); Fasta score E(): FT 1.2e-12, 36.8% identity in 163 aa overlap. Contains Pfam FT match to entry PF01252 Peptidase_A8, Signal peptidase FT (SPase) II. Contains PS00855 Signal peptidases II FT signature." FT /db_xref="GOA:Q9X7E7" FT /db_xref="InterPro:IPR001872" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7E7" FT /protein_id="CAC31580.1" FT /translation="MMGRVPDGPTGLAALVPSVEEAQAMLPPRRLRLLLSIAAVVLTLD FT IVTKVLAVKFLLPGKSVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVIGIFW FT MGRRLVSSWWALGLGMILGGAMGNLVDRFFRAPAPLRGHVVDFLSIGWWPVFNVADPSV FT VVGAILLVVLSIFGFDFDTVGRRKAEFDIAGQRKAEQR" FT misc_feature 68722..69177 FT /note="Pfam match to entry PF01252 Peptidase_A8, Signal FT peptidase (SPase) II, score 238.50, E-value 9.4e-68" FT misc_feature 68995..69027 FT /note="PS00855 Signal peptidases II signature" FT CDS 69353..70279 FT /transl_table=11 FT /gene="ML1200" FT /product="putative pseudouridine synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative pseudouridine synthase TR:Q9X7E8 FT (EMBL:AL049478) (308 aa); Fasta score E(): 0, 99.7% FT identity in 308 aa overlap orthologues of which are known FT to be responsible for the synthesis pseudouridine from FT uracil within the 23s rRNA. Also highly similar to several FT others e.g. Mycobacterium tuberculosis RV1540 SW:Y04P_MYCTU FT (Q10786) (308 aa); Fasta score E(): 0, 88.9% identity in FT 307 aa overlap and Escherichia coli SW:RLUD_ECOLI (P33643) FT (326 aa); Fasta score E(): 9.8e-23, 34.3% identity in 312 FT aa overlap. Contains Pfam match to entry PF00849 FT PseudoU_synth_2, RNA pseudouridylate synthase. Contains FT PS01129 Rlu family of pseudouridine synthase signature." FT /db_xref="GOA:Q9X7E8" FT /db_xref="HSSP:1PRZ" FT /db_xref="InterPro:IPR006225" FT /db_xref="UniProtKB/TrEMBL:Q9X7E8" FT /protein_id="CAC31581.1" FT /translation="MTDRSMPIPEGLAGMRVDAGLARLLGLSRTAVAALAEDGGVELDG FT VQAGKSDRLTSGAWLQVRLCEAPAPLENTPVDIEDMTILYSDDDIVAVDKPAAVAAHAS FT VGWAGPTVLGGLAAAGYRITTSGVPERQGIVHRLDVGTSGVMLVAISERAYTVLKRAFK FT CRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHTWKFAVTKDGRHSITHYDTLEAFVAA FT SLLDVHLETGRTHQIRAHFAELHRPCCGDLVYGADPKLAKRLGLERQWLHARSLSFAHP FT ADGRRVEIVSSYPPDLQHALDVLRAES" FT misc_feature 69617..70081 FT /note="Pfam match to entry PF00849 PseudoU_synth_2, RNA FT pseudouridylate synthase, score 208.50, E-value 1e-58" FT misc_feature 69755..69799 FT /note="PS01129 Rlu family of pseudouridine synthase FT signature" FT CDS complement(70299..70937) FT /pseudo FT /transl_table=11 FT /gene="ML1201" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1597 (Best blastx score 186)" FT CDS complement(71084..71528) FT /pseudo FT /transl_table=11 FT /gene="ML1202" FT /product="lipoprotein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lprI (Best blastx score 128)" FT CDS complement(71619..71933) FT /pseudo FT /transl_table=11 FT /gene="glbN" FT /gene_synonym="ML1203" FT /product="hemoglobin-like, oxygen carrier (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT glbN (Best blastx score 104)" FT CDS 72219..73196 FT /pseudo FT /transl_table=11 FT /gene="ML1204" FT /product="probable fatty-acyl CoA reductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1543 (Best blastx score 277)" FT CDS 73218..73978 FT /pseudo FT /transl_table=11 FT /gene="ML1205" FT /product="probable ketoacyl reductase (pseudogene)" FT /note="Highly similar to Mycobacterium tuberculosis FT probable ketoacyl reductase Rv1544 TR:Q10782." FT CDS 74118..74540 FT /pseudo FT /transl_table=11 FT /gene="ML1206" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1546 (Best blastx score 213)" FT CDS 74614..78147 FT /transl_table=11 FT /gene="dnaE" FT /gene_synonym="ML1207" FT /product="DNA polymerase III, [alpha] subunit" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative DNA polymerase III alpha chain TR:Q9X7F0 FT (EMBL:AL049478) (1177 aa); Fasta score E(): 0, 100.0% FT identity in 1177 aa overlap. Also highly similar to DNA FT polymerases from e.g. Mycobacterium tuberculosis Rv1547 FT SW:DP3A_MYCTU (Q10779) (1184 aa); Fasta score E(): 0, 91.2% FT identity in 1176 aa overlap and Escherichia coli DnaE or FT PolC SW:DP3A_ECOLI (P10443) (1160 aa); Fasta score E(): 0, FT 36.1% identity in 1193 aa overlap. Contains Pfam match to FT entry PF02193 POLIIIAc, DNA polymerase alpha chain like FT domain." FT /db_xref="GOA:Q9X7F0" FT /db_xref="InterPro:IPR004805" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7F0" FT /protein_id="CAC31588.1" FT /translation="MNQSSFVHLHNHTEYSMLDGAAKITPMFAEVERLQMPAVGMTDHG FT NMFGASEFYNTAIKAGIKPIIGVEAYIAPGSRFDTRRITWGDPSQKADDVSAGGAYTHL FT TMVAENAAGLRNLFKLSSLASFEGQLSKWSRMDAELIGEYAEGIIVTTGCPSGEVQTRL FT RLGHDREALESAAKWREIVGPDNYFLELMDHGLSIEQRVREGLLNIGRKLNIPPLATND FT CHYVTRDAVHNHEALLCVQTGKTLSDPNRFKFHGDGYYLKSAAEMRQLWDDEVPGACDS FT TLLIAERVQSYADVWEPRNRMPVFPVPVGHDQASWLRHEVDAGLKRRFPDGPPNGYVER FT AAYEIDVICDKGFPAYFLIVADLVNHARSVGIRVGPGRGSAAGSLAAYALGITDIDPIP FT HGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKTKAAL FT KDSARIHYGQPGFAMADRITKALPPAIMAKDIPLSGITDPAHERFKEAAEVRSLIETDS FT DVRIIYQTARGLEGLIRNAGVHACAVILSSEPLTEAIPLWKRPQDGAIITGWDYPACEA FT IGLLKMDFLGLRNLTIIGDAIENIKTNRGIDLDLESVPLDDQATYELLGRGDTLGVFQL FT DGGPMRDLLRRMQPTGFEDIVAVLALYRPGPMGMNAHNDYADRKNNRQVIKPIHPELEE FT PLREILAETYGLIVYQEQIMRIAQKVAGYSLARADILRKAMGKKKREVLEKEFEGFSEG FT MQANGFSVHAIKALWDIILPFADYAFNKSHAAGYGLISYWTAYLKANFAGEYMAGLLTS FT VGDDKDKAAVYLADCRKFGITVLPPDVNESVLDFASVGADIRYGLGAVRNVGANVVGSL FT IKTRNAKGKFADFSDYLNKIDITSCNKKVTESLIKAGAFDSLGHSRKGLFLVHADAVDS FT VLGTKKAEAIGQFDLFGGTDGGTDAVFTIKVPDDEWEDKHKLALEREMLGLYVSGHPLN FT GVAHLLAAQVDTAIPTILDGGVSNDTQVRVGGILAAVNRRVNKNGIPWASAQLDDLTGG FT IEVMFFPHTYSSYGADIIDDAVVLVNAKVVVRDDRIALIANQLVVPDFSNVQEDRPLAV FT SLLTRQCTFDKVNALKQVLARHPGTSQVHLRLISGDRITTLELDQSLRVTSSPALMGDL FT KALLGPGCLGD" FT misc_feature 74632..74835 FT /note="Pfam match to entry PF02193 POLIIIAc, DNA polymerase FT alpha chain like domain, score 120.50, E-value 3.2e-32" FT repeat_region 78153..78952 FT /note="Dispersed repeat, RLEP, copy 15" FT CDS 79376..79812 FT /pseudo FT /transl_table=11 FT /gene="ML1208" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1558 (Best blastx score 405)" FT repeat_region complement(79685..79770) FT /note="86 bp repeat, 97% identical to region FT 1641317..1641402 " FT CDS 79851..81134 FT /transl_table=11 FT /gene="ilvA" FT /gene_synonym="ML1209" FT /product="threonine deaminase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable threonine threonine deaminase (EC 4.2.1.16) FT TR:Q9X7F1 (EMBL:AL04947) (427 aa); Fasta score E(): 0, FT 100.0% identity in 427 aa overlap. Highly similar to many FT other threonine deaminases including: Mycobacterium FT tuberculosis Rv1559 SW:THD1_MYCT and Corynebacterium FT glutamicum SW:THD1_CORGL (Q04513) (436 aa); Fasta score FT E(): 0, 60.7% identity in 415 aa overlap. Contains Pfam FT match to entry PF00585 Thr_dehydrat_C, C-terminal domain of FT Threonine dehydratase. Contains Pfam match to entry PF00291 FT S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. FT Contains PS00165 Serine/threonine dehydratases FT pyridoxal-phosphate attachment site." FT /db_xref="GOA:Q9X7F1" FT /db_xref="HSSP:1TDJ" FT /db_xref="InterPro:IPR011820" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7F1" FT /protein_id="CAC31590.1" FT /translation="MSAEPSRNPRTPPVSAVDIDGAAKRIAPVVTPTPLQLSDRLSAIT FT GAAVYLKREDLQTVRSYKLRGAYNLLVQLTDEEIAAGVVCSSAGNHAQGVAYACRSLGV FT HGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAAAAAVDDIERTGATLVPPYDD FT VRVIAGQGTIAVELLEQLNTEPDLVVVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGA FT AAMMAALAAGEPVTLDYVDQFVDGAAVNRVGTLPYAALTAAGDMVSITTVDEGAVCTAM FT LDLYQNEGIIAEPAGALSVAGLLETDIEPGSTVVCLISGGNNDVLRYGEVLERSLIHLG FT LKHYFLVDFPQKPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIQLGSAVDLD FT VLLARMQGTEMHVETLQPGSPAYRYLLL" FT misc_feature 79926..80813 FT /note="Pfam match to entry PF00291 S_T_dehydratase, FT Pyridoxal-phosphate dependent enzyme, score 304.70, E-value FT 1.1e-87" FT misc_feature 80010..80051 FT /note="PS00165 Serine/threonine dehydratases FT pyridoxal-phosphate attachment site" FT misc_feature 80847..81125 FT /note="Pfam match to entry PF00585 Thr_dehydrat_C, FT C-terminal domain of Threonine dehydratase, score 140.60, FT E-value 2.8e-38" FT CDS 82694..82879 FT /transl_table=11 FT /gene="ML1210" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CC69" FT /protein_id="CAC31591.1" FT /translation="MVPDEAVSITRLLDSGWVAAPETHFRIRAGPGMRIILADLTADEI FT EPFSDDAIAHQGWPSI" FT CDS complement(83180..84037) FT /pseudo FT /transl_table=11 FT /gene="glgY" FT /gene_synonym="ML1211" FT /product="putative [alpha]-amylase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT glgY (Best blastx score 368)" FT CDS complement(84047..86235) FT /pseudo FT /transl_table=11 FT /gene="glgX" FT /gene_synonym="ML1212" FT /product="probable glycogen debranching enzyme FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT glgX (Best blastx score 387)" FT CDS complement(86279..88480) FT /transl_table=11 FT /gene="ML1213" FT /product="conserved membrane protein" FT /note="Previously sequenced Mycobacterium leprae putative FT membrane protein (fragment) TR:Q9X7F3 (EMBL:AL049478) (274 FT aa); Fasta score E(): 0, 100.0% identity in 274 aa overlap. FT Also similar to a number of Prokaryotic and Eukaryotic FT proteins of undefined function including: Mycobacterium FT tuberculosis Rv1565c TR:O06625 (EMBL:Z95586) (729 aa); FT Fasta score E(): 0, 76.5% identity in 729 aa overlap and FT Caenorhabditis elegans TR:O62230 (EMBL:Z81528) (698 aa); FT Fasta score E(): 5.2e-09, 24.8% identity in 646 aa overlap. FT Contains multiple possible membrane spanning hydrophobic FT domains." FT /db_xref="GOA:Q9CC68" FT /db_xref="InterPro:IPR002656" FT /db_xref="UniProtKB/TrEMBL:Q9CC68" FT /protein_id="CAC31594.1" FT /translation="MSSVNWRSIMQTLSPASLLVATAKPVPLEGRTAVFTIFYRHDLDG FT LRGIAIALVAIFHVWFGRVSGGVDVLLAMSGFFFGGKILRAALNPVPSLSPVAEIIRLV FT RRLLPALVVVLTGCALLTVVMQPQTRWETFADQSLASLGYYQNWELVGTESSYLKAGEA FT VSPLQHIWSMSVQGQFDIAFLLLVAGCAYLFRRPLGTQLRIMFVVLLGALMIASFIYAT FT FAHQANQTTAYYNSFARAWELLLGALVGAAVPYIRWPAWLRTVVATVALAAILSCGALI FT NGVKEFPGPWALVPVGAAMLLILAGANRQSRPGTSASMPLPNRLLATAPLVALGTIAYT FT LYLWHWPLLIFWLSYTGHHHANFVEGAALLLVSGLLAYLTTRLIENPLRYRTLANTEYP FT SPARAAAWQLRLHRSTIALGSMVVLLGVALTATSFTWRQHVIVLRATGKELSALNAQDY FT PGARALTAHARVPTLPMRPTVLEIKDDLPASTRDGCISDFVNPAVVNCTYGDASANRTI FT ALAGGSHAEHWLPALDVLGQLHHFKVVTYLKMGCPLSTEHVPLIMGNNTPYPQCREWVQ FT TTMTKLFSDRPDYVFTTSTRPWNTKPGDVMPATYLGIWQALSDNNIPILAMRDTPWLVK FT NGQPSNPADCLAKGGNAVSCGIKRSNVLADRNPTLNFVAQFSLLKPLDMSDAICRPDIC FT RAVEGNVLIYHGTHHLSPTYVRTLADELGRQIAENTGWW" FT RBS complement(88482..88488) FT CDS complement(88610..89248) FT /transl_table=11 FT /gene="ML1214" FT /product="putative secreted p60-family protein" FT /note="Previously sequenced Mycobacterium leprae TR:Q49634 FT (EMBL:U00010) (246 aa); Fasta score E(): 0, 100.0% identity FT in 206 aa overlap. This predicted product of this CDS is FT similar to several including a portion of Listeria FT monocytogenes SW:P60_LISMO (P21171) (484 aa); Fasta score FT E(): 0.0013, 29.7% identity in 148 aa overlap FT invasion-associated protein P60 and several other proteins FT of undefined function e.g. Mycobacterium tuberculosis FT Rv1566c TR:O06624 (EMBL:Z95586) (230 aa); Fasta score E(): FT 0, 69.4% identity in 209 aa overlap. Contains a possible FT N-terminal signal sequence. Contains Pfam match to entry FT PF00877 NLPC_P60, NLP/P60 family." FT /db_xref="InterPro:IPR000064" FT /db_xref="UniProtKB/TrEMBL:Q9CC67" FT /protein_id="CAC31595.1" FT /translation="MNRIYTFVTGLAMLVTSILTCSLAYADSGTRTADYQQTIDTVVQR FT ALAQRGVPFSWAGGGVSGPTRGTGTGSNTVGFDASGLIQYAYAGAGLKLPRSSGEMYKV FT GQKVLPRHARRGDLIFYGPEGTESVTLYLGDEKMVEVGEVVQVSPVRSNGMAPYLVRVL FT GTQPTSVPQAPLQQVPTLPAPQQTPTHRAPLQHMPLQVPVRPVPVSTAR" FT misc_feature complement(88754..89113) FT /note="Pfam match to entry PF00877 NLPC_P60, NLP/P60 FT family, score 168.30, E-value 1.2e-46" FT CDS complement(89601..89854) FT /pseudo FT /transl_table=11 FT /gene="ML1215" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1567c (Best blastx score 76)" FT CDS 90197..91507 FT /transl_table=11 FT /gene="bioA" FT /gene_synonym="ML1216" FT /product="adenosylmethionine-8-amino-7-oxononanoate FT aminotransferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae adenosylmethionine-8-amino-7-oxononanoate (EC FT 2.6.1.62) SW:BIOA_MYCLE (P45488) (436 aa); Fasta score E(): FT 0, 100.0% identity in 436 aa overlap. Also highly similar FT to other proteins which have been shown to be involved in FT the biosynthesis of biotin e.g. Escherichia coli FT SW:BIOA_ECOLI (P12995) (429 aa); Fasta score E(): 0, 50.0% FT identity in 418 aa overlap BioA and Mycobacterium FT tuberculosis Rv1568 SW:BIOA_MYCTU (O06622) (437 aa); Fasta FT score E(): 0, 85.1% identity in 436 aa overlap, BioA. FT Contains Pfam match to entry PF00202 aminotran_3, FT Aminotransferases class-III pyridoxal-phosphate. Contains FT PS00600 Aminotransferases class-III pyridoxal-phosphate FT attachment site." FT /db_xref="GOA:P45488" FT /db_xref="HSSP:1QJ3" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P45488" FT /protein_id="CAC31597.1" FT /translation="MSGATSGLTPEQIGAIDAAHLWHPYSTIGAATGVIPPVVAVAAHG FT AWLTLIRDGKPIEALDAMSSWWTAIHGHGHSVLDAALTTQLGAMNHVMFGGLTHEPAAR FT LAQLLVDITPAGLETVFFSDSGSVSVQVAVKMALQYWRSRGQPAKRRLMTWRGGYHGDT FT LTPMSICDPDGGMHSLWTDILARQVFAPQVPRDYDPAYSKAFETQLAQHTPELAAVVVE FT PVVQGAGGMRFHDPRYLCDVRDICRRHDVLLIFDEIATGFGRTGELFAADHCGVSPDIM FT CVGKALTGGYLSLAATLCTTDIAHAISVGAAGALMHGPTFMANPLACAVSVASVEVLLG FT QDWRSRVAEISAGLTAGLEAAQGLPGVIDVRVCGAIGVIECDRSVDLAVATPAALDRRV FT WLRPFRNLVYAMPPYICPPAEIAQITSAMVEVAGLVG" FT misc_feature 90329..91438 FT /note="Pfam match to entry PF00202 aminotran_3, FT Aminotransferases class-III pyridoxal-phosphate, score FT 444.00, E-value 7e-154" FT misc_feature 90953..91066 FT /note="PS00600 Aminotransferases class-III FT pyridoxal-phosphate attachment site" FT CDS 91514..92671 FT /transl_table=11 FT /gene="bioF" FT /gene_synonym="ML1217" FT /product="8-amino-7-oxononanoate synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae 8-amino-7-oxononanoate synthase (EC 2.3.1.47) FT SW:BIOF_MYCLE (P45487) (385 aa); Fasta score E(): 0, 100.0% FT identity in 385 aa overlap. Also highly similar to many FT othes e.g. Escherichia coli SW:BIOF_ECOLI (P12998) (384 FT aa); Fasta score E(): 0, 36.9% identity in 379 aa overlap, FT involved in biotin biosynthesis, and Mycobacterium FT tuberculosis Rv1569 SW:BIOF_MYCTU (O06621) (386 aa); Fasta FT score E(): 0, 80.1% identity in 381 aa overlap. Contains FT Pfam match to entry PF00222 aminotran_2, Aminotransferases FT class-II. Contains PS00599 Aminotransferases class-II FT pyridoxal-phosphate attachment site." FT /db_xref="GOA:P45487" FT /db_xref="HSSP:1BS0" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P45487" FT /protein_id="CAC31598.1" FT /translation="MKVPIETSPLAWLEAVEQQRRGAGLRRSLRPRSAVATELDLASND FT YLGLSQHPDVIDGGVAALRVWGAGATGSRLVTGDTILHHELECELAEFVGACVGLLFSS FT GYAANLGAVVGLSGPGSLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALRSCH FT EERAVVVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRGGGRGLVYEVGLA FT GAPDVVITTTMSKALGSQGGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGAARAALQI FT LKAETWRPEAVLQHARTLAKICDLSELPQSAVVSVVLGDPEVALAAAIACLDAGVRVGC FT FRPPTVPAGTSRLRLTAHASLDSAKLEVARRVLTDVLGGCCVARR" FT misc_feature 91745..92575 FT /note="Pfam match to entry PF00222 aminotran_2, FT Aminotransferases class-II, score 407.50, E-value 1.3e-118" FT misc_feature 92207..92236 FT /note="PS00599 Aminotransferases class-II FT pyridoxal-phosphate attachment site" FT CDS 92668..93348 FT /transl_table=11 FT /gene="bioD" FT /gene_synonym="ML1218" FT /product="dethiobiotin synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae dethiobiotin synthetase (EC 6.3.3.3) SW:BIOD_MYCLE FT (P45486) (223 aa); Fasta score E(): 0, 99.6% identity in FT 223 aa overlap. Also highly similar to several others FT involved in biotin biosynthesis e.g. Mycobacterium bovis FT SW:BIOD_MYCBO (O52587) (226 aa); Fasta score E(): 0, 74.2% FT identity in 225 aa overlap and Mycobacterium tuberculosis FT Rv1570 SW:BIOD_MYCTU (O06620) (226 aa); Fasta score E(): 0, FT 74.2% identity in 225 aa overlap." FT /db_xref="GOA:P45486" FT /db_xref="HSSP:1DAI" FT /db_xref="InterPro:IPR004472" FT /db_xref="UniProtKB/Swiss-Prot:P45486" FT /protein_id="CAC31599.1" FT /translation="MTVVVVTGTDTGVGKTVACAALACHARQAGIEVAVCKPVQTGTQI FT GDDDLAEVARLSGVTELTGLVRYPQPLAPAAAAEHAGMALPTREQLLELIAGLDRPGRL FT ILVEGAGGLLVELADASATLRDLAVELGALALVTVSVELGTLNHTALTLEALTTRGVAC FT AGLVIGSWTGRPGAVQISNRSALARLAPMRATLPAGAGSMDATDFAAMSAAAFDRDWVT FT TLVH" FT CDS 93345..93857 FT /pseudo FT /transl_table=11 FT /gene="ML1219" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT protein Rv1571 TR:O06619" FT RBS 94089..94095 FT CDS 94102..95139 FT /transl_table=11 FT /gene="bioB" FT /gene_synonym="ML1220" FT /product="biotin synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae biotin synthase (EC 2.8.1.6) SW:BIOB_MYCLE (P46715) FT (345 aa); Fasta score E(): 0, 99.1% identity in 345 aa FT overlap. Also highly similar to several others involved in FT biotin biosynthesis e.g. Escherichia coli SW:BIOB_ECOLI FT (P12996) (346 aa); Fasta score E(): 0, 35.3% identity in FT 309 aa overlap and Mycobacterium tuberculosis FT TR:BIOB_MYCTU. Contains Pfam match to entry PF01792 FT Biotin_synth, Biotin synthase." FT /db_xref="GOA:P46715" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/Swiss-Prot:P46715" FT /protein_id="CAC31601.1" FT /translation="MTQAGTRSTNGDTENTDILAQARQQVLERGEGLSRDQVLQMLWLP FT DDRLEELLALAHDVRMRWCGPEVEIEGIISLKTGGCPEDCHFCSQSGLFMSPVRSAWLD FT IRSLVEAAKQTAKSGATEFCIVAAVRGPDERLMSQVAAGIEAIRNEVEINIACSLGMLT FT VEQVEQLSGIGVHRYNHNLETARSFFTNVVTTHTWEERWQTLSMVRDAGMEVCCGGILG FT MGETVEQRAEFALELAELGPDEVPLNFLNPRPGTPFGALEVMPPSEALKSVAAFRLALP FT RTILRFAGGREITLGDLGAKQGMLGGINAVIVGNYLTTLGRPAEADLRLLDDLQMPIKA FT LNASL" FT misc_feature 94192..95112 FT /note="Pfam match to entry PF01792 Biotin_synth, Biotin FT synthase, score 689.70, E-value 1.4e-203" FT RBS 95158..95162 FT CDS 95165..95407 FT /transl_table=11 FT /gene="ML1221" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49616 (EMBL:U00010) (80 FT aa); Fasta score E(): 0, 98.8% identity in 80 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1590 TR:O06600 (EMBL:Z95586) (79 FT aa); Fasta score E(): 3.4e-21, 67.1% identity in 73 aa FT overlap." FT /db_xref="UniProtKB/Swiss-Prot:Q49616" FT /protein_id="CAC31602.1" FT /translation="MVQDLPTPIGAGIYNIYTGVKHRDELAGASMPTVAQLGLEPPRFC FT AECGRRMVVQVRPDGWRAKCSRHGQVDSVDMEAKR" FT RBS 95392..95396 FT CDS 95404..96000 FT /transl_table=11 FT /gene="ML1222" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49626 (EMBL:U00010) (198 FT aa); Fasta score E(): 0, 99.5% identity in 198 aa overlap. FT Highly similar to proteins of undefined function also found FT downstream of BioB orthologues in Mycobacterium FT tuberculosis Rv1591 TR:O06599 (EMBL:Z95586) (221 aa); Fasta FT score E(): 0, 63.8% identity in 188 aa overlap and FT Mycobacterium bovis BCG TR:O52590 (EMBL:AF041819) (193 aa); FT Fasta score E(): 0, 67.6% identity in 170 aa overlap." FT /db_xref="GOA:Q49626" FT /db_xref="UniProtKB/Swiss-Prot:Q49626" FT /protein_id="CAC31603.1" FT /translation="MTEHCASDISDVSCPPRGRVIVGVVLGLAGTGALIGGLWAWIAPP FT IHAVVGLTRTGERGHDYLGNESEHFFVAPCLMLGLLTVLAVTASVLAWQLRQHRGPGMV FT IGLAIGLMICAATAAAVGALLVWMRYGALNFDAVPLSYDHKVAHVIQAPPVFFAHGLLQ FT VAATVLWPAGIAALVYAVLAAANGRDDLGGRLCSR" FT CDS complement(96089..97265) FT /pseudo FT /transl_table=11 FT /gene="ML1223" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1592c (Best blastx score 313)" FT CDS complement(97547..98266) FT /transl_table=11 FT /gene="ML1224" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein TR:Q49628 (EMBL:U00010) (286 aa); FT Fasta score E(): 0, 100.0% identity in 233 aa overlap. Also FT highly similar toseveral other proteins of unproven FT function including: Mycobacterium tuberculosis hypothetical FT protein Rv1593c TR:O06597 (EMBL:Z95586) (236 aa); Fasta FT score E(): 0, 85.7% identity in 238 aa overlap and FT Streptomyces coelicolor TR:Q9S233 (EMBL:AL109848) (239 aa); FT Fasta score E(): 1.1e-19, 38.2% identity in 191 aa overlap FT putative DNA hydrolase." FT /db_xref="GOA:Q9CC66" FT /db_xref="InterPro:IPR000086" FT /db_xref="UniProtKB/TrEMBL:Q9CC66" FT /protein_id="CAC31605.1" FT /translation="MAYASTAHEVLAVVFQVRRVAEQVKGTPQKAKPQLSVLLWERSQD FT PQRGAWSLPGGRLRNDEDMTYSVRRQLAEKVDLRELAHLEQLAVFSEPARLPGTRMIAS FT TFLGLVPSPATPELPPDTRWHPLNTLPSMAFDHGPMVTHARARLVAKMSYTNIGFALAP FT KEFALSTLRDIYGATLGYQVDATNLQRVLARRSVIIQTGTVAQSGRSGGRPAALYRFTD FT SQLRVTDEFAALRPPGN" FT RBS 98303..98310 FT CDS 98313..99371 FT /transl_table=11 FT /gene="nadA" FT /gene_synonym="ML1225" FT /product="quinolinate synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable quinolinate synthetase A TR:Q49622 FT (EMBL:U00010) (368 aa); Fasta score E(): 0, 100.0% identity FT in 352 aa overlap. Also similar to quinolinate synthetases FT from Escherichia coli SW:NADA_ECOLI (P11458) (347 aa); FT Fasta score E(): 2.6e-27, 33.3% identity in 330 aa overlap FT and Mycobacterium tuberculosis Rv1594 TR:O06596 FT (EMBL:Z95586) (349 aa); Fasta score E(): 0, 84.4% identity FT in 352 aa overlap." FT /db_xref="GOA:Q49622" FT /db_xref="InterPro:IPR003473" FT /db_xref="UniProtKB/Swiss-Prot:Q49622" FT /protein_id="CAC31606.1" FT /translation="MTVLNGMEPLAGDMTVVIAGITDSPVGYAGVDGDEQWATEIRRLT FT RLRGATVLAHNYQLPAIQDIADYVGDSLALSRIAAEVPEETIVFCGVHFMAETAKILSP FT NKTVLIPDQRAGCSLADSITPDELCAWKDEHPGAAVVSYVNTTAEVKALTDICCTSSNA FT VDVVESIDPSREVLFCPDQFLGAHVRRVTGRKNVYVWMGECHVHAGINGDELVDQARAN FT PDAELFVHPECGCSTSALYLAGEGAFPPDRVKILSTGGMLTAARQTQYRKILVATEVGM FT LYQLRRAAPEIDFRAVNDRASCKYMKMITPGALLRCLVEGTDEVHVDSEIAAAGRRSVQ FT RMIEIGLPGGGE" FT RBS 99357..99363 FT CDS 99368..100951 FT /transl_table=11 FT /gene="nadB" FT /gene_synonym="ML1226" FT /product="L-aspartate oxidase" FT /note="Previously sequenced Mycobacterium leprae FT L-aspartate oxidase (EC 1.4.3.16) SW:NADB_MYCLE (Q49617) FT (424 aa); Fasta score E(): 0, 99.8% identity in 400 aa FT overlap. Note ML1226 differs in length from that previously FT sequenced, possibly due to a frameshift in the original FT sequence. Highly similar to several proteins involved in FT quinolinate biosynthesis e.g. Mycobacterium tuberculosis FT SW:NADB_MYCTU (O06595) (527 aa); Fasta score E(): 0, 76.7% FT identity in 529 aa overlap and Escherichia coli FT SW:NADB_ECOLI (P10902) (540 aa); Fasta score E(): 6.2e-31, FT 38.8% identity in 533 aa overlap. Contains Pfam match to FT entry PF00890 FAD_binding_2, FAD binding domain." FT /db_xref="GOA:Q49617" FT /db_xref="HSSP:1CHU" FT /db_xref="InterPro:IPR005288" FT /db_xref="UniProtKB/Swiss-Prot:Q49617" FT /protein_id="CAC31607.1" FT /translation="MMAVPDWKHAADVVVIGTGVAGLAAALAAHRAGRNVVVLTKADQR FT RGETATHYAQGGIAVVLPGSDDSVDAHASDTLAAGAGMCNLDTVYSIVAEGYHAVTELV FT GYGARFDESIPGRWAVTCEGGHSRRRIVHAGGDATGAEVQRALDHAADVLDIRTSHLAL FT RVLHDGTVVNGVSVLNPNGWGIVSAPSVILASGGLGHLYGATTNPEGSTGDGIALALWA FT GVAVSDLEFIQFHPTMLFAAGTGTGGRRPLVTEAIRGEGAILLDSKGNSVTSGVHPLGD FT LAPRDVVAAAIDARLKATGDSCVYLDARGIDGFASRFPTVTAACRTVGIDPAREPIPVV FT PGAHYSCGGIVTDAYGQTELAGLFAAGEVARTGMHGANRLASNSLLEGLVVGGRAGRAA FT AAHAAAAGRAYVSKLEPVTHHALKRRELQRVMSRDAAVMRNAAGLQRLSDTLAEAPIRH FT VTGRRDFEDVALTLTARAVAAAALARNESRGCHHCTEYPDTAPEHARSTVIRLADDQNL FT VRAEALATVG" FT misc_feature 99701..100636 FT /note="Pfam match to entry PF00890 FAD_binding_2, FAD FT binding domain, score 484.60, E-value 7.6e-142" FT RBS 100942..100946 FT CDS 100948..101808 FT /transl_table=11 FT /gene="nadC" FT /gene_synonym="ML1227" FT /product="nicotinate-nucleotide pyrophosphatase FT [carboxylating]" FT /note="Identical to the previously sequenced Mycobacterium FT leprae nicotinate-nucleotide pyrophosphorylase FT [carboxylating] (EC 2.4.2.19)(quinolinate FT phosphoribosyltransferase [decarboxylating]) SW:NADC_MYCLE FT (P46714) (284 aa); Fasta score E(): 0, 100.0% identity in FT 284 aa overlap. Also highly similar several others from to FT Mycobacterium tuberculosis SW:NADC_MYCTU (O06594) (285 aa); FT Fasta score E(): 0, 79.2% identity in 283 aa overlap and FT Escherichia coli SW:NADC_ECOLI (P30011) (296 aa); Fasta FT score E(): 2.6e-32, 40.4% identity in 272 aa overlap. FT Contains Pfam match to entry PF01729 QRPTase, Quinolinate FT phosphoribosyl transferase." FT /db_xref="GOA:P46714" FT /db_xref="HSSP:1QPO" FT /db_xref="InterPro:IPR002638" FT /db_xref="UniProtKB/Swiss-Prot:P46714" FT /protein_id="CAC31608.1" FT /translation="MIMLSDCEFDAARDTIRRALHEDLRYGLDITTQATVPAGTVVTGS FT MVPREPGVIAGVDVALLVLDEVFGVDGYRVLYRVEDGARLQSGQPLLTVQAAARGLLTA FT ERTMLNLVCHMSGIATVTVAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRVGGGVNHR FT LGLGDTALIKDNHVAAVGSVVDALRAVRAAAPELPCEVEVDSLEQLDAMLAEEPELILL FT DNFPVWQTQVAVQRRDIRAPTVLLESSGGLSLENAAIYAGTGVDYLAVGALTHSVRILD FT IGLDL" FT misc_feature 101017..101805 FT /note="Pfam match to entry PF01729 QRPTase, Quinolinate FT phosphoribosyl transferase, score 543.70, E-value 1.2e-159" FT stem_loop complement(101849..101902) FT /note="54 bp palindrome " FT repeat_region complement(102547..103315) FT /note="Dispersed repeat, RLEP, copy 16" FT CDS 104865..105643 FT /pseudo FT /transl_table=11 FT /gene="ML1228" FT /product="probable esterase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lipO (Best blastx score 158)" FT CDS 105899..112255 FT /transl_table=11 FT /gene="pks3" FT /gene_synonym="ML1229" FT /product="mycocerosic acid synthase (polyketide synthase)" FT /note="Identical to many polyketide synthases involved in FT the biosynthesis of mycocerosyl lipids e.g. Mycobacterium FT tuberculosis probable mycocerosic acid synthase Rv2940c FT TR:P96291 (EMBL:Z83858) (2111 aa); Fasta score E(): 0, FT 60.8% identity in 2127 aa overlap and Mycobacterium bovis FT mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa); FT Fasta score E(): 0, 58.8% identity in 2127 aa overlap. FT Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding FT dehydrogenases. Contains Pfam match to entry PF00109 FT ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match FT to entry PF00698 Acyl_transf, Acyl transferase domain. FT Contains Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site. Contains PS00606 FT Beta-ketoacyl synthases active site." FT /note="Highly similar to many other M. leprae polyketide FT synthases ML0101, ML0135, ML0139, ML2353, ML2354, ML2355, FT ML2356 and ML2357" FT /db_xref="GOA:Q49624" FT /db_xref="HSSP:1PQW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q49624" FT /protein_id="CAC31610.1" FT /translation="MRAANVTPVAVIGMACRLPGGIDSPQRLWEALLRGDDLVTEIPKE FT RWDADLYYDPEPGVPGRSVSRWGAFLDDVGGFDCDFFGMTEREAIAIDPQHRLLLETSW FT DAIEHAGLDPATLAGSATGVFVGLTHGDYELLSADCGATEGPYGFTGTSNSFASGRVAY FT TLGLHGPAVTVDTACSSGLMAVHQARGSLDCGESDLALAGGVVVTLEPRKSVSGSLQGM FT LSPTGRCHAFDVAADGFVSGEGCVVLLLKRMPDAERDGDRILAVLRGTAANQDGHTVHI FT AAPSEQAQIAVYHKALAVGGVDPTTVGLIEAHGTGTPVGDPIEYASLAAVYGTAGRCAL FT ASTKTNFGHMQSTSGPLGMMKAILALQHGVVPKNLHFTRLPDQLAEITTELFVPQVNTP FT WPVDVQQPRRAAVSSYGMSGTNVHAILEQAPENSGKDSPAVSKVNGPLLFPLSATSVEQ FT LRATAARMADWVDEHGSGTKHTGLWDLGYTLSRRRGYRPVRTMVLASSFAELSRGLREI FT AGSEIPYQSAVGQDDRGPVWVFSGQGSQWAGMGAELFAKEPVFAAAIAAMEPVIVEESG FT FSVTEALTVAEKVTGIDRVQPTIFAIQVALAATMKSYGVYPGAVIGHSLGEAAAAVAAG FT ALSCEDGLRVICRRSQLMSRVAGSGAMASVELPGQQVLSELSIRGLSDVVLAVVASPTS FT TVVGGDTQAIRHLLAAWQAQDVMVREVAVDVASHTPQVEPILDDLVETLADLKPTEPKV FT PYYSATLWDPRERPSFTGEYWAENLRYTVRFAAAVQAALKDGFRVFGELAPHPLLTYAI FT EQNAASLDMPVSALAAMRREQELPFGLRGFIADVHSAGALVDFSVQYPNGCLVDAPLPT FT WTRRELMLSRESVDHPAHGAAVQAVHPLLGAHVHLFEEPERHVWQGRVGTEAHPWLGDH FT QIHDVAAFPGAAYCEMALTAARVTLGEASEVRDIKFEQTLLLDRETMASSAATVSAPGV FT LEFAVETYEEGERVRRASAVLRALEDRVNQQPASHSIDALIASHPLRTEGADLRATFDA FT IGIQYGLAFSGLTAVYTAAGTNEDVSTVLAEVALPGAIRSQQASYTSHPALLDACFQSV FT IVAPEVQKAGAGGLLLPVYVRRLLNYHSMRNAQYCLTRVKTSRAGECEVDLEVLDQSGA FT VLLLVEGLRLAGGASEHECANRVLDERLFTVEWEPRELPEVTQRERGSWLVLGASAEDP FT LVQQLGDALNADGGHCTAVSLPLGQIDTAQLCSLLSRDGVSSSIGHGALKGLTGVVVVT FT APPATVAESPALRRGRDYVSHLITIVREISELPGERPRLFVVTRNAASIKTGDLANLEQ FT VGLRGLIRVIDSEHPYLSVTQIDVEETNQATIATQVARQLRSGSDEDETGWRDGEWYTA FT RLRPGPLRQAERRTVVVQNEHDGMRLEIRTPGDLDSLEFVAFDRVPPGPGEIEVAVTAS FT TVNFADVLVAFGRYPTFEGYCQLLGIDFAGVVSAVGLNVTDHKVGDRVGGVSRNGCWTT FT FVICDARHAVTLSPEVPLEEAAAVPTVAATAWYGLHDLARISQTDKVLIHSGTGGVGQA FT AIAIARAAGCEIFATAGSPQRRQLLRDKGIEHVYDSRSLEFAEQIHRDTKGYGVDVVLN FT SLPGAAQRAGIELLAFGGRFVEIGKRDIYGDTRLGLFPFRRNLSLYAVDLALLTYTHPD FT TVRRLLTTVYQRTAEGVLPVPQTTHYPIHNTANAVRLVAGAGHTGKVLLDVPHTGSSVA FT VVPPEQVRTFRADGAYIVTGGLTGLGLFLGTEMAAAGCGRIVLNSRSAPNPQAQETIER FT LRAGGADIQVECGDIAEPRVADRLVVAATQSGLPVRGVLHAAGVVEDATLTNVTDDLID FT RCWAPKVYGAWNLHQALQEGKTAQLLDWFCSFSTAAALVGSPGQGAYAAANSWLDGFSY FT WRRAQGLASTTIAWGAWGELGLATALAEMAGVAIAPTEGARVFQTLLRYNRPYSCYAPI FT METPWLKSFAQHSRFAEAFRSISQGQKDKSKFLAELKVLPRDEWPSMIRRLVSEQISLL FT LRRTIDPDRLLSDYGLDSLGNLELRTRIETETGIRISPTKITTIRSLAEHLCEELAATE FT AESAVTAT" FT misc_feature 105923..107188 FT /note="Pfam match to entry PF00109 ketoacyl-synt, FT Beta-ketoacyl synthase, score 575.50, E-value 3.3e-169" FT misc_feature 106403..106453 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 107501..108457 FT /note="Pfam match to entry PF00698 Acyl_transf, Acyl FT transferase domain, score 419.90, E-value 2.3e-122" FT misc_feature 110198..111139 FT /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding FT dehydrogenases, score -6.40, E-value 2.1e-09" FT misc_feature 112010..112204 FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 49.80, E-value FT 3.6e-12" FT RBS 112324..112329 FT CDS 112336..113751 FT /transl_table=11 FT /gene="papA3" FT /gene_synonym="ML1230" FT /product="PKS-associated protein, unknown function" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49618 (EMBL:U00010) (471 FT aa); Fasta score E(): 0, 99.8% identity in 471 aa overlap. FT Also highly similar to Mycobacterium tuberculosis proteins FT encoded downstream of several polyketide synthases e.g. FT Rv1182 TR:O50438 (EMBL:AL010186) (472 aa); Fasta score E(): FT 0, 75.8% identity in 471 aa overlap." FT /db_xref="InterPro:IPR001242" FT /db_xref="UniProtKB/TrEMBL:Q49618" FT /protein_id="CAC31611.1" FT /translation="MQVGPLTLGTLLDWAPRAGKTISWQPTPATCEKVSQAPVSSVPVA FT YMQAQHIRGYVEQKAKGLDYSRLMIVSCDQLGQCDIRAINYIVNAHLRRHDTYRSWFEY FT TDEGEIIRHTLCDPADIEFVPIEHGQLSLAQIRELAVSTPDPLEWGCFQFGVIQAEEHF FT TFYASIDHVHVDAMIVGVTLMEFHMMYSALVSGAGPLELPEAGSYDDFCRRQHRFTSML FT TAESPQIRSWTQFAEPNEGSFPDFPLPLGDPLEPTQADIVTITMLDEQQTDRFEAACTV FT AGARFVGGVLACCGLAEYELTGADTYYGLTPRDTRRIPTDVLTQGWFTGLVPITVPIAG FT SSFGDAARAAQNCFDTDVHLAEVPYDRVVELAPTVHKPRPNFPVINFLDAGTAPLSVLL FT TAGLDGLNIGVYSDGRYSYQMSIYVIRVEQETAVAVMFPDNPEAQESVARYLETLKSVF FT ECVAESGHWRNVA" FT RBS 113822..113826 FT CDS 113833..116784 FT /transl_table=11 FT /gene="mmpL10" FT /gene_synonym="ML1231" FT /product="conserved large membrane protein" FT /note="Previously sequenced Mycobacterium leprae membrane FT protein MMPL10 SW:MMLA_MYCLE (Q49619) (1008 aa); Fasta FT score E(): 0, 100.0% identity in 983 aa overlap. Also FT highly similar to many MMPL-family Mycobacterium FT tuberculosis proteins e.g. Rv1183 SW:MMLA_MYCTU (O50439) FT (1002 aa); Fasta score E(): 0, 70.4% identity in 978 aa FT overlap. Contains possible membrane spanning hydrophobic FT domains." FT /note="Similar to ML2378 and ML0137" FT /db_xref="GOA:Q49619" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/Swiss-Prot:Q49619" FT /protein_id="CAC31612.1" FT /translation="MVIGCWTLLALMLPMTVPSLTELTQRHPVVILPVDAPSSVAAKKI FT SQAFHEVDSENVLIVLLTDDKGLGPADETVYRTLVDRLRNDTKDVVVLQDFLSTPPLHE FT LLVSKDGKAWILPIVLAGELGTSASYQAYAGVAGIVKQTLESTAGSSLKANLTGPASTV FT ADLTDAGARDRTSIELVIAVLLLTILMIIYRNPITMLLPLITIGASLMTAQAVVSGVSV FT LAGLAVSNQMIVLLSAMIAGAGTDYAVFLISRYHDYIRMGSGSAQDAGCAVRQALISLG FT KVIAASAATVGITFLGMSFTKIRVFSTVGPALAIGIAVAFLAAVTLMPALLVLAGTRGW FT VAPRRDRAGAFWRRTGVRIVRRPVAYLSASMVILIVLALCASLVRFNYDDRKQIPASDE FT SSVGYAALESHFPVGQAIPEYLLIQSPHDLRTPRALADMAELAQRVSQIPGIALVRGVT FT RPTGKPLEETSATYQAGMVGKQLGSASHLIGESTGDLNRLASGAGLLADKLGDVRIQVG FT QAVAGISGLLDNLAFAQKMFGDSKTLGEIDTAGKLVSSMRALGNMFGINFSTTMNDINW FT VGAVVIALDSSVLCDTNPICADARAQFHKLLTASEDGTLDNIAHLWKQLGSTQSSQTIG FT ATVSGLEKTLTAVNTSLRSLGLDNPNVMRSKMIGLQNGVNDLASAGRRIADGVAVLVDQ FT TRTMGTSLARASAFLMEMGQDASQPSMAGFNVPPQLLNTEDFKKLVQAFISPDGHSVRY FT FIQTDLNPFSSAAMDQVNTILNVATGAQPNTTLSDASIYLSGYTVTLRDTRDYYDRDLQ FT LIVIVTMIVVLLILMALLRSIVAPIYLVGSVIVSYLSALGLCVLVFQVLLRQQLHWSVP FT GLAFVVLVAVGADYNMLLASRLRDESSHGLRASVIRTVRSTGGVITAAGLIFAASMFGL FT LLSSIATVVQAGFVLGSGILLDTFIVRTITVPAVAALLRRASWWPARPWGNNA" FT CDS complement(117212..118288) FT /transl_table=11 FT /gene="ML1232" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49633 (EMBL:U00010) (391 FT aa); Fasta score E(): 0, 100.0% identity in 358 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1184c TR:O50440 (EMBL:AL010186) (359 FT aa); Fasta score E(): 0, 62.7% identity in 338 aa overlap. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="InterPro:IPR013228" FT /db_xref="UniProtKB/TrEMBL:Q9CC62" FT /protein_id="CAC31613.1" FT /translation="MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPPSPVPVRENS FT PAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPARAPFRYVPTFLVPGPRD FT EVTIGEAIAVATKNLNQAIHRGTEPAAVVGLSQGSLALDTEQEQLATDPTAPPPDQLTF FT NTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMPQRMDSQYDSNRVVAAYDGLSEFPD FT RADNLLAQLNCFAGGAISHTPSGFFNPEDVPPQNIRTTVNSRGAKTTTYLIPVNHLPLT FT LPLRYLGWSDALVDQIDAVLQPKIDAAYAYNDNPLNKPISVDPVNGMDPIAGIDAELRD FT SILNVFAQLRSILPPPPG" FT misc_feature complement(117755..117778) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(118453..119145) FT /transl_table=11 FT /gene="ML1233" FT /product="conserved membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49630 (EMBL:U00010) (230 FT aa); Fasta score E(): 0, 100.0% identity in 230 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv3821 TR:O07802 (EMBL:Z97188) (237 FT aa); Fasta score E(): 2.9e-31, 46.7% identity in 240 aa FT overlap. Contains multiple possible membrane spanning FT hydrophobic domains." FT /db_xref="UniProtKB/TrEMBL:Q49630" FT /protein_id="CAC31614.1" FT /translation="MWITILLMAIAISLEPFRIGMTVLMLNRPRPTLQLLVFLCSGFTM FT GMTVGFVVLFVFRRRLMASMQLTLPKVQILIGVLALLVAAVLTVQVCISSEPPAESPVD FT SASGPPKPSKWAPRPLARLLNGDSLWVAGVAGLGIALPSVDYLAALAVILTSGAAATTQ FT VGALLMFNVVAFALIEIPLAAYLLAPDTTRAWTAALNNWIRSRRRLEVATLLAGVSCLL FT LAVGIAGL" FT CDS complement(119175..120914) FT /transl_table=11 FT /gene="ML1234" FT /product="possible acyl-CoA synthase" FT /note="Highly similar to acyl-CoA synthases from FT Mycobacterium tuberculosis Rv1185c TR:O50441 FT (EMBL:AL010186) (578 aa); Fasta score E(): 0, 72.4% FT identity in 579 aa overlap and Mycobacterium bovis FT TR:P71495 (EMBL:U7568) (582 aa); Fasta score E(): 0, 63.4% FT identity in 579 aa overlap. Contains Pfam match to entry FT PF00501 AMP-binding, AMP-binding enzyme." FT /note="Similar to ML0100, ML0132, ML0138, ML0243 and FT ML2358" FT /db_xref="GOA:P54200" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/Swiss-Prot:P54200" FT /protein_id="CAC31615.1" FT /translation="MQNSSVLSFLRERAGLQPDDEAFSFTDYEQDWAGVRKTLTWAQLY FT QRTLNVAHELRRHGSIRDRAVILAPQGLDYIIAFLGAMQAGFIAVPLSVPQAGSHDERV FT GAVLADTSPSVVLTTSAVADAIAKYVDHSDTDTVPAILEVDSPNLDVENKSNIRLTDAP FT STAYLQYTSGSTRLPAGVMVTHRNLMVNFQQLMADYFAPTNGVAPLDLTIVSWLPFYHD FT MGLVLGVVAPILGGWRSELTSPISFLQRPARWIQAMATSSHPFSAGPNFAFELAARRTS FT DADIAGLDLGACQGIISGSERIHPATLNRFSDRFARINFRDDMMLPSYGLAEGTVYAAS FT RPKGSSPEVVYFEPAKLSEGTVKRCEARTGAPLLSYGTPKSPIVRIVDSDTCIECPTGR FT VGEIWLHGDNVAEGYWHKPEETQRTFGGKLANPSPGTPEGPWLRTGDLGFISEDELFIV FT GRMKDLLIVYGRNHYPEDIESTVQEITGGRVAAISVPVDETEKLVTIIEVKKRGDSDAE FT AMQKLVAVKNNITAAISKSHGLNVADLVLVPPGSIPTTTSGKVRRTACVEQYRRQQFSR FT LDG" FT misc_feature complement(119439..120797) FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score -16.10, E-value 1.6e-14" FT CDS 122362..124909 FT /pseudo FT /transl_table=11 FT /gene="pks9" FT /gene_synonym="ML1235" FT /product="polyketide synthase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pks9 (Best blastx score 267)" FT CDS 125555..126599 FT /pseudo FT /transl_table=11 FT /gene="pks11" FT /gene_synonym="ML1236" FT /product="polyketide synthase (chalcone synthase-like) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pks11 (Best blastx score 356)" FT CDS complement(126570..126788) FT /pseudo FT /transl_table=11 FT /gene="ML1237" FT /product="possible cytochrome P450 (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Probable cytochrome P450 Rv1666c" FT CDS complement(126591..126761) FT /pseudo FT /transl_table=11 FT /gene="ML1238" FT /product="Probable cytochrome p450 (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1666c (Best blastx score 147)" FT CDS complement(126873..127314) FT /pseudo FT /transl_table=11 FT /gene="ML1239" FT /product="Probable ABC transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1667c (Best blastx score 184)" FT CDS complement(127026..127650) FT /pseudo FT /transl_table=11 FT /gene="ML1240" FT /product="probable ABC transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1668c (Best blastx score 93)" FT CDS 128151..129035 FT /transl_table=11 FT /gene="ML1241" FT /product="possible enoyl-CoA hydratase/isomerase" FT /note="Highly similar to Mycobacterium tuberculosis FT probable enoyl-CoA hydratase Rv1472 EchA12 (EC 4.2.1.17) FT SW:ECHC_MYCTU (O53163) (285 aa); Fasta score E(): 0, 72.0% FT identity in 271 aa overlap and Clostridium acetobutylicum FT 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) SW:CRT_CLOAB FT (P52046) (261 aa); Fasta score E(): 5.1e-18, 31.1% identity FT in 264 aa overlap. Contains Pfam match to entry PF00378 FT ECH, Enoyl-CoA hydratase/isomerase family. Contains PS00166 FT Enoyl-CoA hydratase/isomerase signature." FT /db_xref="GOA:P53526" FT /db_xref="HSSP:1MJ3" FT /db_xref="InterPro:IPR018376" FT /db_xref="UniProtKB/Swiss-Prot:P53526" FT /protein_id="CAC31622.1" FT /translation="MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSM FT ALDLMKSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVEGLTQPVRALR FT AMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVASTRAYFRAAGINNGLS FT ASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAAR FT MATFSRSGTELTKRALWGGLDAASLDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPT FT VLVDARGCATSPG" FT misc_feature 128244..128774 FT /note="Pfam match to entry PF00378 ECH, Enoyl-CoA FT hydratase/isomerase family, score 155.70, E-value 8e-43" FT misc_feature 128520..128582 FT /note="PS00166 Enoyl-CoA hydratase/isomerase signature" FT CDS 129893..131775 FT /pseudo FT /transl_table=11 FT /gene="ML1242" FT /product="transcriptional regulator (LuxR/UhpA family) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0386 (Best blastx score 259)" FT repeat_region 131912..132626 FT /note="LEPRPT, copy 3, 715 bp region identical to 1254 bp FT LEPRPT element. Truncated at 5'-end" FT tRNA complement(133048..133121) FT /gene="argW" FT /note="tRNA Arg anticodon TCT, Cove score 69.26" FT CDS 133733..134194 FT /transl_table=11 FT /gene="ML1243" FT /product="hypothetical protein" FT /note="function unknown." FT /db_xref="UniProtKB/TrEMBL:Q9CC60" FT /protein_id="CAC31624.1" FT /translation="MVASCLPRKWEGLPDVCLAVRSRCWYRFFVWHWSINIKRGQAYSL FT PNRGMELSGICVLVNGQQGFALCLAGSHLRLKRLSRGYAITLLTAAADSERFNAAAPIS FT YTQSEASSCLMLHGEEKNPLAPSAKAHAFCAALLTVGVRTGPCRHPRRD" FT CDS 134417..135892 FT /transl_table=11 FT /gene="ML1244" FT /product="conserved membrane protein" FT /note="Highly similar to a family of Mycobacterium FT tuberculosis proteins e.g. Rv2484c SW:YO84_MYCTU (O53209) FT (491 aa); Fasta score E(): 0, 75.2% identity in 483 aa FT overlap. Contains possible membrane spanning hydrophobic FT domains." FT /db_xref="InterPro:IPR004255" FT /db_xref="UniProtKB/TrEMBL:Q9X7A8" FT /protein_id="CAC31625.1" FT /translation="MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTPD FT WNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRRVRVPDPGTLRE FT VFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQISHAITDGVGSVEMFAEMYDL FT ERDPPSRPRSPQPIPQDLSRNDLMLQGINHLPVALAGGVVGGLSGVASVAGRAILRPAS FT TVSGVVGYVRSGIRVLSQAAEPSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDA FT YLAGLVGALRRYHEALGVSISTLPMAVPVNVRTEADVVGSNRFVGVTLAAPLGTNDPAA FT RMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDSVASSDVNASNIPAYPGD FT TYFAGAKILRQYGIGPRPGVAMMAVLMSRGGFCTVTVRYDRASVKSEALFARCLLEGFD FT EVLALAGDPTPHAVPASFAARSSGSPAGWLSSS" FT CDS 135889..137628 FT /transl_table=11 FT /gene="ML1245" FT /product="possible transferase" FT /note="The N-terminus is similar to several phosphoserine FT phosphatases e.g. Haemophilus influenzae SW:SERB_HAEIN FT (P44997) (795 aa); BlastP Expect 9.8 and the C-terminus is FT similar to many Prokaryotic and Eukaryotic FT acyltransferases e.g. Salmonella typhimurium FT 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC FT 2.3.1.51) SW:PLSC_SALTY (P26974) (245 aa); Fasta score E(): FT 1.4e-11, 35.3% identity in 167 aa overlap. Highly similar FT over entire protein to Mycobacterium tuberculosis putative FT transferase Rv2483c TR:O53208 (EMBL:AL021246) (580 aa); FT Fasta score E(): 0, 77.1% identity in 573 aa overlap. FT Contains Pfam match to entry PF01553 Acyltransferase, FT Acyltransferase." FT /db_xref="GOA:Q9X7A9" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/TrEMBL:Q9X7A9" FT /protein_id="CAC31626.1" FT /translation="MSAFDENGTPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLV FT AGFTAVILTHERLRRCDMGVGELLSMIQAGLNHTLGRIEFEDLIGKVSSALRGRLLTDL FT EEIGERLFAQRIESRIYPEMRKLVQAHVARGHTVVLSSSALTIQVGPVARFLGIAHMLT FT NKFEINEDGMLTGGVVKPILWGPGKAAAVQRFAAEHDIDLKDSYFYADGDEDVALMYLV FT GNPRPTNPEGKMAAVAKRRGWPILKFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGV FT LTGSRRRGANFFTSVFPPLVLAAAGVHLNVIGNENLTMQRPAVFIYNHRNQIDPLIAGA FT LVRGNWIAVAKKELAKNPIIRALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLSILM FT APEGTRLDTTEVGPFKKGPFRIAMAVGIPIVPIVFRNAEIVAARNSNTINPGMVDVAVL FT PAIPVDDWTLDALSERIAEVRQLYLDILADWPVDELPKAALYTRATKATVKKAEPKKGG FT RTSAAKTTAKKTATKATAAKTANTAVTKSMLTPPTRISDKENPKVPKVVSQDLVVKQPR FT ERS" FT misc_feature 136828..137355 FT /note="Pfam match to entry PF01553 Acyltransferase, FT Acyltransferase, score 131.70, E-value 1.3e-35" FT CDS 137625..139952 FT /transl_table=11 FT /gene="plsB" FT /gene_synonym="ML1246" FT /product="glycerol-3-phosphate acyltransferase" FT /note="Highly similar to many acyltransferases including: FT Escherichia coli glycerol-3-phosphate acyltransferase (EC FT 2.3.1.15) SW:PLSB_ECOLI (P00482) (806 aa); Fasta score E(): FT 1.5e-27, 24.4% identity in 693 aa overlap and Mycobacterium FT tuberculosis putative acyltransferase PlsB2 (RV2482C) FT SW:PLS2_MYCTU (O53207) (789 aa); Fasta score E(): 0, 80.7% FT identity in 783 aa overlap. Contains Pfam match to entry FT PF01553 Acyltransferase, Acyltransferase." FT /db_xref="GOA:Q9X7B0" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7B0" FT /protein_id="CAC31627.1" FT /translation="MTEPDVEISSVLTGEDTLVLASMDTPAEIELVMDWLCQQRNRNPD FT IKFDVLKLPSRNLAPAALTALVEQLESDEDRSVVPVRVFWMPPAERSKLAKLAGLLPGR FT DPYHPNRRQQRHILKTDARRALVIAGDSAKVSELRQYWRDTTVGENECDFAQFVTRRAI FT LAMERAESRILGPQYKSPRLVKPEILASTRFRAGLEKISGATVEEAGKMLDELATGWSR FT ASVDLVSVLGRMLSRGFEPEIDYDEYQVAAMRAALEAHPAVLLFSHRSYIDGAVVPVAM FT QENRLPPVHVFAGINLSFGLMGPLLRRSGVIFIRRNIGDNPLYKYVLREYVGYIVEKRF FT NLSWSIEGTRSRTGKMLPPKLGLLTYVADAYLDGRSEDILLQPVSISFDQLHETAEYAA FT YARGGEKTPEGVAWLYSFIKAQGERNYGKIYVRFPEAVSMRQYLGAPHGALVQDQDAKR FT LALQKMSFEVAWRILCATPVTATALVSALLLTTRGVALTLDQLHHTLQESLDYLERKQT FT PVSKSALRLRSREGVRAAVDALSSGHPITRVDSGREPVWYITPGNEHAAAFYRNSVIHA FT FLETSIVELALAHARHVEGDRMKVFWAQAMRLRDLLKFDFYFADSAAFRANIAEEIAWH FT QNWEDRVSGDGDDIDAMLLTKRPLISDAMLRVFFEAYDIVADVLRDAPADVGQKELTEL FT ALGVGRQYVAQGRVRSGESVSTLLFATAYQVVVDQNLIAPAPDLAERRMVFRRELRDIR FT RDFDYVEQIARSRFIVREFKSR" FT misc_feature 138381..138956 FT /note="Pfam match to entry PF01553 Acyltransferase, FT Acyltransferase, score 113.40, E-value 4.2e-30" FT CDS 140319..140615 FT /pseudo FT /transl_table=11 FT /gene="ML1247" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2478c (Best blastx score 155)" FT CDS 140770..142440 FT /transl_table=11 FT /gene="ML1248" FT /product="ABC-transporter protein, ATP binding component" FT /note="Highly similar to many proposed ABC-transporter FT ATP-binding proteins including:Escherichia coli SW: FT YJJK_ECOLI and Mycobacterium tuberculosis RV2477C TR:O53204 FT (EMBL:AL021246) (558 aa); Fasta score E(): 0, 92.3% FT identity in 557 aa overlap. Contains 2 Pfam matches to FT entry PF00005 ABC_tran, ABC transporter. Contains 2 x FT PS00017 ATP/GTP-binding site motif A (P-loop). Contains 2 x FT PS00211 ABC transporters family signature." FT /db_xref="GOA:Q9X7B1" FT /db_xref="HSSP:1US8" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q9X7B1" FT /protein_id="CAC31629.1" FT /translation="MAEFIYTMKKVRKAHGDKVILDDVTLNFFPGAKIGVVGPNGAGKS FT SVLRIMAGMDKPNNGDAFLATGASVGILQQEPPLNEEKTVRGNVEEGLGDIKIKLDRFS FT EVAELMATDSSSELMEEMGRLQEELDHADAWDLDSQLEQAMDVLRCPPPDEPVTNLSGG FT ERRRVALCKLLLSKPDLLLLDEPTNHLDAESVQWLEQHLAGYAGAVLAVTHDRYFLDNV FT AEWILELDRGRAYPYEGNYSTYLEKKAERLTTQGRKDAKLQKRLTDELAWVRSGAKARQ FT AKSKARLQRYEEMAAEAEKNRKFDFEEIQIPVGPRLGNMVVEVEHLDKGYGGRTLIKDL FT SFTLPRNGIVGIIGPNGVGKTTLFKTIVGLEQPDGGAVKIGETVKLSYVDQTRAGIDPK FT KIVWEVVSDGLDHIQVGQTEVSSRAYVSAFGFKGPDQQKLAGVLSGGERNRLNLALTLK FT QGGNLILLDEPTNDLDVETLGSLENALVNFPGCAVVISHDRWFLDRTCTHILAWEGDDE FT GKWFWFEGNFGAYEENKVERLGAEAARPHRVTHRKLTRD" FT misc_feature 140860..141465 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 173.70, E-value 2.9e-48" FT misc_feature 140881..140904 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 141247..141291 FT /note="PS00211 ABC transporters family signature" FT misc_feature 141808..142314 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 125.60, E-value 9.3e-34" FT misc_feature 141829..141852 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 142096..142140 FT /note="PS00211 ABC transporters family signature" FT CDS 142499..147367 FT /transl_table=11 FT /gene="ML1249" FT /product="conserved hypothetical protein" FT /note="Similar to several proteins of undefined function FT including: Mycobacterium tuberculosis RV2476C TR:O53203 FT (EMBL:AL021246) (1624 aa); Fasta score E(): 0, 81.5% FT identity in 1634 aa overlap and Rickettsia prowazekii FT TR:Q9ZCI2 (EMBL:AJ235273) (1581 aa); Fasta score E(): 0, FT 32.9% identity in 1494 aa overlap." FT /db_xref="GOA:Q9X7B2" FT /db_xref="InterPro:IPR007780" FT /db_xref="UniProtKB/TrEMBL:Q9X7B2" FT /protein_id="CAC31630.1" FT /translation="MTIDPGATHVAELCTTFTQGADVPDWISKAYIDSYRGSHGDVREA FT PETSRVNPNALVTPAMLSAHYRLGQCRPNGRNCVRVYPADDPAGFGPALQIVTDHGGMV FT MDSITVLLHRLGVTYTAMMTPVFMVLRSPTGELLGVEPRASSTSHSIEGTWVGEVWIYI FT QLLPAVDSKSLAEVEQLLPRTLVDVQRVAADAAALNATLSGLAADVKTNKEGHFSASDR FT DDVAALLHWLGNGNFLLLGYQRCRVHYGLVSCDRSTGLGVLRARTGSRPRLTDDNELLV FT LAQAAVGNYLRYGAYPYAIAVREYDDGGDGGIIEHRFVGLFTVAAMNADVLEIPSISHR FT VRAALAMANSDPIYPGQLLLDVIQTVPRSELFTLSAERLFTMAKEVVDLGSGRRALLFL FT RADRLQYFVSCLVYVPRDRYTTGVRLQIEDILVREFGGTQVEFTARVSESPWALMHFMV FT RLSEGAATGSVDVSEGNRIRIQAMLSEAARTWSDRLIAAAASFSEGSVSYAEAEHYAAT FT FSETYKQAVTPADAIDHIAIIKELADDSVKLVFFERKADGFAQLTWFLGGRSASLSQLL FT PMLQSMGVVVLEERPFTVARTDGLPVWIYQFKISPHPTIPLASTANERELTAKRFSDAV FT TAIWQGRVEIDRFNELVMRARLTWQQVVLLRAYAKYLRQAGFNYSQSYIESVLNEHPST FT ARSLVALFEALFDPSPLSSSTNCDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATL FT RTNYFVTQKFSARSKGVLVLKLDAQLINELPLPRPKFEIFVYSPRVEGVHLRFGAVARG FT GLRWSDRLDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVLKRPPLPTGDAAADRDAMRA FT EGIACYQLFISGLLDITDNVDHATGKVNAPPQVVRRDSDDAYLVVAADKGTATFSDIAN FT DVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAWEAVKRHFREMGVDTQNEDFTVVGI FT GDMSGDVFGNGMLLSKHIRLIAAFDHRHVFLDPDPDAAVSWAERQRMFDLPRSSWDDYN FT KSLISEGGGVYSREQKAIPTSPQVRTALGIDGEVTEMAPPNLIRAILQAPVDLLFNGGI FT GTYIKAETESVADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSGGRINT FT DAMDNSAGVDCSDHEVNIKILIDSLVTAGKVKVEERKHLLESMTDEVARLVLTDNEDQN FT DLIGTSRANAANMLSVHAMQIKYLVDERGVNRELEALPSEKEIQRRSEAGIGLTSPELS FT TLMAHVKLALKEQMLATELPDQDVFVSRLPRYFPKPLRERFTPEIRSHQLRREIVTTML FT INDLVDTAGISYAFRIAEDIGVGPIDAIRTYVATDAIFGVGDVLRRIRAANLSVVLSDR FT MTLDTRRLIDRAGRWLLNYRPQPLAVGAEINRFAAKVKALTPRMSEWLRGDDQAIVEQQ FT ATEFVSQGAPEDLAYRVAVGLYRYSLLDIIDIADITELDPAEVADTYFSLMDRLGTDGL FT LTAVSKLPQNDRWHSLARLAIRDDIYASLRSLCFDVLAVGEPDESGEEKIAEWEHISAS FT RVERARLMLAEIHASGEKDLATLSVAARQIRRMTRTSGRGSSG" FT CDS 147364..147755 FT /pseudo FT /transl_table=11 FT /gene="ML1250" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2475c (Best blastx score 137)" FT CDS 147780..148315 FT /pseudo FT /transl_table=11 FT /gene="ML1251" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2474c (Best blastx score 207)" FT CDS complement(148385..149733) FT /pseudo FT /transl_table=11 FT /gene="ML1252" FT /product="probable maltase [alpha]-glucosidase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2471 (Best blastx score 408)" FT CDS complement(149751..150137) FT /transl_table=11 FT /gene="glbO" FT /gene_synonym="ML1253" FT /product="hemoglobin-like, oxygen carrier" FT /note="Highly similar to putative globins from FT Mycobacterium tuberculosis RV2470 TR:O53197 (EMBL:AL021246) FT (128 aa); Fasta score E(): 0, 88.7% identity in 124 aa FT overlap and Mycobacterium bovis TR:AAF36597 (EMBL:AF213450) FT (128 aa); Fasta score E(): 0, 88.7% identity in 124 aa FT overlap." FT /db_xref="GOA:Q9CC59" FT /db_xref="InterPro:IPR001486" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC59" FT /protein_id="CAC31634.1" FT /translation="MQQSFYDAIGGAETFKAIVSRFYAQVPEDEILRELYPADDLAGAE FT ERLRMFLEQYWGGPRTYSSQRGHPRLRMRHAPFRITAIERDAWLRCMHTAVASIDSHTL FT DNEHRRELLDYLEMAAHSLVNSAS" FT CDS 150306..150953 FT /transl_table=11 FT /gene="ML1254" FT /product="conserved hypothetical protein" FT /note="Highly similar to several proteins of unknown FT function including: Mycobacterium tuberculosis RV2469C FT TR:O53196 (EMBL:AL021246) (222 aa); Fasta score E(): 0, FT 77.9% identity in 222 aa overlap and Streptomyces FT coelicolor TR:CAB71830 (EMBL:AL138662) (178 aa); Fasta FT score E(): 0, 52.8% identity in 161 aa overlap. Contains FT Pfam match to entry PF01844 HNH, HNH endonuclease." FT /db_xref="GOA:Q9X7B4" FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:Q9X7B4" FT /protein_id="CAC31635.1" FT /translation="MVQRKNRRSHRSSGAAANLIRAANPSSLHNVDIHPSTCYESGSIW FT NRRRVLLLNSTYEPLTALPTRRAIIMVICGKADVVHVDPAGPVVHSATRSITVPSVIQL FT RSYVRVPYRARVPMTRAALMHRDRFCCAYCGAKADTVDHVVPRSRGGDHSWENCVACCS FT TCNHRKGDKLLTELGWVLRRTPVLPTGQHWRLLSTVKELDPAWARYLGGGAA" FT misc_feature 150690..150824 FT /note="Pfam match to entry PF01844 HNH, HNH endonuclease, FT score 56.00, E-value 8.2e-13" FT CDS 151368..151859 FT /transl_table=11 FT /gene="ML1255" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein RV2468C TR:O53195 (EMBL:AL021246) (167 FT aa); Fasta score E(): 0, 81.2% identity in 165 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CC58" FT /protein_id="CAC31636.1" FT /translation="MGHQSSQSEVAPVVRGDVVTELPKGWVITTSGRVSGVTEPGDRSV FT HYPFPIKDLVALDDALTYSSRASHARFAVYLGDLGNDTAALAREILAQVPTPDDAVLVA FT VSPNQCAIEVVYGSQVRGRGAESAAPLGVAAASSAFEQGNLIDGLISAVRVLSAGISRS FT " FT repeat_region complement(151846..152602) FT /note="Dispersed repeat, RLEP, copy 17" FT CDS complement(153370..153783) FT /pseudo FT /transl_table=11 FT /gene="ML1256" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1598c (Best blastx score 161)" FT CDS 153897..155246 FT /transl_table=11 FT /gene="hisD" FT /gene_synonym="ML1257" FT /product="histidinol dehydrogenase" FT /note="Highly similar to many histidinol dehydrogenases (EC FT 1.1.1.23) constituting the first stage in the histidine FT biosynthetic pathway e.g. Mycobacterium tuberculosis RV1599 FT SW:HISX_MYCTU (Z95586) (438 aa); Fasta score E(): 0, 84.8% FT identity in 442 aa overlap and Mycobacterium smegmatis FT SW:HISX_MYCSM (P28736) (445 aa); Fasta score E(): 0, 77.5% FT identity in 449 aa overlap. Contains Pfam match to entry FT PF00815 Histidinol_dh, Histidinol dehydrogenase. Contains FT PS00611 Histidinol dehydrogenase signature." FT /db_xref="GOA:Q9CC57" FT /db_xref="HSSP:1K75" FT /db_xref="InterPro:IPR012131" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC57" FT /protein_id="CAC31638.1" FT /translation="MSITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPI FT VQAVAECGADAALEFGALFDGVRPPTVRVPDAALDAALAGLDPDVRDALQVMIERTRVV FT HADQRRTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSL FT VVASPPQFTSGGRFHGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDSDDCELA FT PVDMITGPGNIYVTAAKRLCRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQAEHD FT EMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAALGGRQSAIILVDDLEAGVKVV FT NLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSG FT GLSVQTFLRGIHVVNYTKTALKDISGHVITLAKAEDLPAHGEAVRRRFAR" FT misc_feature 153966..155240 FT /note="Pfam match to entry PF00815 Histidinol_dh, FT Histidinol dehydrogenase, score 753.30, E-value 1e-222" FT misc_feature 154638..154736 FT /note="PS00611 Histidinol dehydrogenase signature" FT CDS 155243..156376 FT /transl_table=11 FT /gene="hisC" FT /gene_synonym="ML1258" FT /product="histidinol-phosphate aminotransferase" FT /note="Highly similar to many histidinol-phosphate FT aminotransferases (EC 2.6.1.9) involved in histidine FT biosynthesis e.g. Mycobacterium tuberculosis RV1600 FT TR:SW:HIS8_MYCTU (O06591) (380 aa); Fasta score E(): 0, FT 83.6% identity in 366 aa overlap and Mycobacterium FT smegmatis SW:HIS8_MYCSM (P28735) (219 aa); Fasta score E(): FT 0, 77.2% identity in 219 aa overlap. Contains Pfam match to FT entry PF00222 aminotran_2, Aminotransferases class-II." FT /db_xref="GOA:Q9X7B8" FT /db_xref="HSSP:1IJI" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7B8" FT /protein_id="CAC31639.1" FT /translation="MNVPEPTLDDLPLRDNLRGKSPYGAMQLLVPVLLNTNENPHPPTK FT ALVDDVVRSVQKVAVDLHRYPDRDAVALRQDLASYLTAQTGIRLGVENIWAANGSNEIL FT QQLLQAFGGPGRSAIGFVPSYSMHPIIADGTHTEWLETVRADDFSLDVEAAVTAVADRK FT PDVVFIASPNNPSGQSISLADLRRLLDVVPGILIVDEAYGEFSSRPSAVALVGEYPTKI FT VVTRTTSKAFAFAGGRLGYLIATPALVEAMLLVRLPYHLSSVTQAAARAALRHADDTLG FT SVAALIAERERVTKSLVHMGFRVIPSDANFVLFGHFSDAAGAWQHYLDTGVLIRDVGIP FT GYLRATTGLAEENDAFLKASSEIAATELAPATTLGAS" FT misc_feature 155504..156274 FT /note="Pfam match to entry PF00222 aminotran_2, FT Aminotransferases class-II, score 172.40, E-value 7.3e-48" FT RBS 156364..156368 FT CDS 156373..157005 FT /transl_table=11 FT /gene="hisB" FT /gene_synonym="ML1259" FT /product="imidazole glycerol-phosphate dehydratase" FT /note="Highly similar to many imidazoleglycerol-phosphate FT dehydratases (EC 4.2.1.19) involved in histidine FT biosynthesis e.g. from Mycobacterium tuberculosis RV1601 FT SW:HIS7_MYCTU (O06590) (210 aa); Fasta score E(): 0, 84.8% FT identity in 210 aa overlap and Streptomyces coelicolor FT SW:HIS7_STRCO (P16247) (197 aa); Fasta score E(): 0, 56.4% FT identity in 202 aa overlap. Contains 2 Pfam matches to FT entry PF00475 IGPD, Imidazoleglycerol-phosphate FT dehydratase. Contains PS00955 Imidazoleglycerol-phosphate FT dehydratase signature 2. Contains PS00954 FT Imidazoleglycerol-phosphate dehydratase signature 1." FT /db_xref="GOA:Q9X7B9" FT /db_xref="InterPro:IPR000807" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7B9" FT /protein_id="CAC31640.1" FT /translation="MTNTEVGKTTRRARIERRTSESDIVVELDLDGTGQVHIDTGVSFY FT DHMLTALGSHASFDLTVCTKGDVEIEAHHTIEDTAIALGQAFGQALGNKKGIRRFGDAF FT IPMDETLVHAVVDVSGRPYCVHTGEPDHLQHNIISGSSVPYSTVINRHVFESLAANARI FT ALHVRVLYGRDPHHITEAQYKAVARALSEAVKFDPRFSGVPSTKGVL" FT misc_feature 156490..156753 FT /note="Pfam match to entry PF00475 IGPD, FT Imidazoleglycerol-phosphate dehydratase, score 191.10, FT E-value 9.2e-65" FT misc_feature 156580..156621 FT /note="PS00954 Imidazoleglycerol-phosphate dehydratase FT signature 1" FT misc_feature 156805..156945 FT /note="Pfam match to entry PF00475 IGPD, FT Imidazoleglycerol-phosphate dehydratase, score 64.70, FT E-value 2.6e-21" FT misc_feature 156886..156924 FT /note="PS00955 Imidazoleglycerol-phosphate dehydratase FT signature 2" FT CDS 157002..157622 FT /transl_table=11 FT /gene="hisH" FT /gene_synonym="ML1260" FT /product="glutamine amidotransferase" FT /note="Highly similar to many glutamine amidotransferases FT involved in histidine biosynthesis including: Mycobacterium FT tuberculosis HisH (RV1602) TR:O06589 (EMBL:Z95586) (206 FT aa); Fasta score E(): 0, 79.4% identity in 204 aa overlap FT and Escherichia coli SW:HIS5_ECOLI (P10375) (196 aa); Fasta FT score E(): 3.9e-20, 41.5% identity in 205 aa overlap. FT Contains Pfam match to entry PF00117 GATase, Glutamine FT amidotransferase class-I. Contains PS00442 Glutamine FT amidotransferases class-I active site." FT /db_xref="GOA:Q9X7C0" FT /db_xref="HSSP:1OX6" FT /db_xref="InterPro:IPR016226" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7C0" FT /protein_id="CAC31641.1" FT /translation="MRSKSVVVLDYGSGNLWSVQRALQRVGAAVEVTADSAAGAAADGL FT LVPGVGAFEACMAGLRKIAGERTIAERIVAGRPVLGVCVGMQILFARGVEFGVETTGCR FT QWPGVVTRLDAPVVPHMGWNVVDSASGSALFKGLDAGVRFYFVHSYAAQRWEGSSKALL FT TWATHQVPFLAAVEEGPLVATQFHPEKSGDAGATLLSNWLGEL" FT misc_feature 157020..157619 FT /note="Pfam match to entry PF00117 GATase, Glutamine FT amidotransferase class-I, score 146.70, E-value 4.2e-40" FT misc_feature 157233..157268 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT CDS 157632..158369 FT /transl_table=11 FT /gene="hisA" FT /gene_synonym="ML1261" FT /product="phosphoribosylformimino-5-aminoimidazole FT carboxamide ribotide isomerase" FT /note="Highly similar to many FT phosphoribosylformimino-5-aminoimidazole carboxamide FT ribotide isomerases (EC 5.3.1.16) involved in histidine FT biosynthesis including: Mycobacterium tuberculosis RV1603 FT SW:HIS4_MYCT (O0658) (245 aa); Fasta score E(): 0, 84.4% FT identity in 244 aa overlap and Streptomyces coelicolor FT SW:HIS4_STRCO (P16250) (240 aa); Fasta score E(): 0, 66.3% FT identity in 240 aa overlap. Contains Pfam match to entry FT PF00977 His_biosynth, Histidine biosynthesis protein." FT /db_xref="GOA:Q9CC56" FT /db_xref="InterPro:IPR010188" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC56" FT /protein_id="CAC31642.1" FT /translation="MMSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAALCWQRDG FT ADWIHLVDLDAAFGRGSNRELLSEMVGKLDVQVELSGGIRDDDSLNAALATGCARVNLG FT TAACENPHWCAQVIAEHGDKIAVGLDVQIVDGQHRLRGRGWETDGGDLWDVLENLDRQG FT CSRFIVTDVTKDGTLDGPNLDLLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEG FT AIVGKALYAERFTLPQALAVVRM" FT misc_feature 157641..158360 FT /note="Pfam match to entry PF00977 His_biosynth, Histidine FT biosynthesis protein, score 161.20, E-value 1.8e-44" FT CDS 158392..159172 FT /pseudo FT /transl_table=11 FT /gene="impA" FT /gene_synonym="ML1262" FT /product="impA, inositol monophosphtase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT impA (Best blastx score 633)" FT CDS 159177..159962 FT /transl_table=11 FT /gene="hisF" FT /gene_synonym="ML1263" FT /product="cyclase" FT /note="Highly similar to many cyclases involved in FT histidine biosynthesis including: Mycobacterium FT tuberculosis RV1605 SW:HIS6_MYCTU (O53908) (267 aa); Fasta FT score E(): 0, 89.8% identity in 256 aa overlap and Bacillus FT subtilis SW:HIS6_BACSU (O34727) (252 aa); Fasta score E(): FT 0, 53.0% identity in 253 aa overlap. Contains Pfam match to FT entry PF00977 His_biosynth, Histidine biosynthesis FT protein." FT /db_xref="GOA:Q9X7C2" FT /db_xref="HSSP:1GPW" FT /db_xref="InterPro:IPR004651" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7C2" FT /protein_id="CAC31644.1" FT /translation="MYSGNGLAVRVIPCLDVYCGRVVKGVNFKNLRDAGDLVELAAAYD FT AEGADELAFLDVTASSSGRATMLEVVRCTAEQVFIPLMVGGGVRTVADVDVLLRAGADK FT VAVNTAAIARPELLADMAGQFGSQCIVLSVDARTVPTGSARTPSGWEATTHGGYRGTGI FT DAVEWAARGADLGVGEILLNSMDADGTKAGFDLAMLRAVRAAVTVPVIASGGAGAIEHF FT VPAVTAGADAVLAASVFHFRELTIGQVKDAMAAAGIAVR" FT misc_feature 159201..159935 FT /note="Pfam match to entry PF00977 His_biosynth, Histidine FT biosynthesis protein, score 378.50, E-value 6.7e-110" FT CDS 159959..160306 FT /transl_table=11 FT /gene="hisI" FT /gene_synonym="ML1264" FT /product="phosphoribosyl-AMP 1,6 cyclohydrolase" FT /note="Highly similar to many phosphoribosyl-AMP FT cyclohydrolases (EC 3.5.4.19) involved in histidine FT biosynthesis including: Mycobacterium tuberculosis RV1606 FT SW:HIS3_MYCTU (O53909) (115 aa); Fasta score E(): 0, 84.3% FT identity in 115 aa overlap and Bacillus subtilis FT SW:HIS2_BACSU (O34912) (209 aa); Fasta score E(): 6.3e-18, FT 50.0% identity in 98 aa overlap. Contains Pfam match to FT entry PF01502 PRA-CH, Phosphoribosyl-AMP cyclohydrolase." FT /db_xref="GOA:Q9X7C3" FT /db_xref="InterPro:IPR002496" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7C3" FT /protein_id="CAC31645.1" FT /translation="MTLDPDIAVRLKRNAEGLFTAVVQERSSGDVLMVAWMDDQALART FT LETREANYYSRSRAEQWIKGSTSGNTQHVHSVRLDCDGDTVLLTVDQVGGACHTGAHSC FT FDSAMLLAPQD" FT misc_feature 160055..160288 FT /note="Pfam match to entry PF01502 PRA-CH, FT Phosphoribosyl-AMP cyclohydrolase, score 166.90, E-value FT 3.3e-46" FT CDS complement(160462..160722) FT /pseudo FT /transl_table=11 FT /gene="ML1265" FT /product="possible membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2345 (Best blastx score 100)" FT CDS complement(160839..161781) FT /pseudo FT /transl_table=11 FT /gene="ML1266" FT /product="serine-threonine protein kinase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pknF (Best blastx score 141)" FT CDS 162040..163134 FT /transl_table=11 FT /gene="ML1267" FT /product="putative antiporter" FT /note="Highly similar to many antiporters e.g. FT Mycobacterium tuberculosis RV1607 TR:O53910 (EMBL:AL022001) FT (360 aa); Fasta score E(): 0, 77.7% identity in 364 aa FT overlap and Escherichia coli SW:CHAA_ECOLI (P31801) (366 FT aa); Fasta score E(): 0, 36.5% identity in 356 aa overlap. FT Contains multiple possible membrane spanning hydrophobic FT domains." FT /db_xref="GOA:Q9X7C4" FT /db_xref="InterPro:IPR004837" FT /db_xref="UniProtKB/TrEMBL:Q9X7C4" FT /protein_id="CAC31648.1" FT /translation="MLKRIAWTALVPLFALAVLALTWGREIGPVVTALQAALLTGAVLA FT AVHHAEVVAHRVGEPFGSLVLAAAVTVIEVALIVTLMASGENESWTLARDTAFAALMIT FT TNGIAGFSLLLGSRRYGVTLFNAHGSGAALATLTTLATLSLVLPTFTTSHRGNEFSPGQ FT LAFAAVASLGLYLLFVFTQTIRHRDFFLPVAQKGQKGLFEEDESHADPPSARSALISLA FT LLLVALIAVVGLAELQSSAIEHLVTAVGFPQPFVGVVIATLVLLPETLAAVRAARRGRI FT QTSLNLAYGSAMASIGLTIPAIALASIWLTGPLILGLGATQLVLLALTVVISVLTVVPG FT RATRLQGEVHLVLLAAFVFLAIIP" FT CDS complement(163181..163630) FT /pseudo FT /transl_table=11 FT /gene="ML1268" FT /product="conserved hypothetical protein (bacterioferritin FT comigratory protein) (pseudogene)" FT /note="Function unknown. Similar to proteins found to FT comigrate with bacterioferritin. Possible pseudogene of M. FT tuberculosis orthologue bcpB (Best blastx score 328)" FT CDS 163739..165328 FT /transl_table=11 FT /gene="trpE" FT /gene_synonym="ML1269" FT /product="anthranilate synthase component I" FT /note="Highly similar to many anthranilate synthase FT component I family proteins (EC 4.1.3.27) involved in FT tryptophan biosynthesis e.g. Mycobacterium tuberculosis FT RV1609 SW:TRPE_MYCTU (O06127) (516 aa); Fasta score E(): 0, FT 88.0% identity in 508 aa overlap and Pseudomonas putida FT SW:TRPE_PSEPU (P20579) (493 aa); Fasta score E(): 0, 44.4% FT identity in 504 aa overlap. Contains Pfam match to entry FT PF00425 chorismate_bind, chorismate binding enzyme." FT /db_xref="GOA:Q9X7C5" FT /db_xref="HSSP:1K0G" FT /db_xref="InterPro:IPR015890" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7C5" FT /protein_id="CAC31650.1" FT /translation="MHAHLAATTSREDFRQLAVDHRVVPVTRKVLADSETPLSAYRKLA FT ANRPSTFLLESAENGRSWSQWSFIGVGAPSALTIRDGEAVWLGTVPQDAPTGGDPLHVL FT QATLELLATAAMPGLPPLSSGMVGFFAYDMVRRLERLPELALNDLQLPDMLLLLATDVA FT AVDHHEGTITLIANAVNWNGTDERVDQAYDDAIARLDVMTAALGQPLPSTIATFSRPDP FT RRRAQCTIEEYGAIVDHLVDQIAAGEAFQVVPSQRFEVDTDVDPIDVYRMLRVTNPSPY FT MYLLHVPNSDGATGFSIVGSSPEALVTVKDGRVTTHPIAGTRWRGQTEEEDQLLEKELL FT ADEKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHVERYSHVMHMVSTVTGLLGEGRT FT ALDAVTACFPAGTLSGAPKVRSMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTA FT LMRDGIAYVQAGGGVVADSNGPYEYIEASNKARAVLNAIAAAETLTSLDFGVALAPGRV FT AARGEAGNQGRL" FT misc_feature 164423..165229 FT /note="Pfam match to entry PF00425 chorismate_bind, FT chorismate binding enzyme, score 498.40, E-value 5.6e-146" FT RBS 165318..165322 FT CDS 165325..166122 FT /transl_table=11 FT /gene="ML1270" FT /product="possible conserved membrane protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein RV1610 TR:O06128 (EMBL:Z95554) (235 FT aa); Fasta score E(): 0, 65.8% identity in 231 aa overlap. FT Contains multiple possible membrane spanning hydrophobic FT domains. Contains Pfam match to entry PF00218 IGPS, FT Indole-3-glycerol phosphate synthases." FT /db_xref="InterPro:IPR019051" FT /db_xref="UniProtKB/TrEMBL:Q9CC55" FT /protein_id="CAC31651.1" FT /translation="MMAPDIKSARAGRLTIQIAQLLLVVAAGALWMAARLPWVVIRSFD FT GLGPPKEVALSGASWSAVLLPLALLMLAATVAAIAVRGWPLRVLAGLLAVASFLVGYLG FT VSLWVLPDVTVRGAVLAHVSLLSLVGSQRHHLGAGAAVAASGCTLIAAVLLMRSASVIG FT SARQGTSKYVVPAQRRSIARRDGAATAISQMSERMIWDALDEDRDPTDRLREPDTEGRW FT WTACRRSLPFMNVVEIGGCTGSVAGRWVTSGKGNDTHVSGNCA" FT CDS 166100..166918 FT /transl_table=11 FT /gene="trpC" FT /gene_synonym="ML1271" FT /product="indole-3-glycerol phosphate synthase" FT /note="Highly similar to many indole-3-glycerol phosphate FT synthases (EC 4.1.1.48) involved in tryptophan biosynthesis FT e.g. Mycobacterium tuberculosis Rv1611 SW:TRPC_MYCTU FT (O06129) (272 aa); Fasta score E(): 0, 90.8% identity in FT 272 aa overlap and Streptomyces coelicolor SW:TRC1_STRCO FT (O68814) (269 aa); Fasta score E(): 0, 64.1% identity in FT 262 aa overlap. Contains Pfam match to entry PF00218 IGPS, FT Indole-3-glycerol phosphate synthases. Contains PS00614 FT Indole-3-glycerol phosphate synthase signature." FT /db_xref="GOA:Q9X7C7" FT /db_xref="HSSP:1PII" FT /db_xref="InterPro:IPR001468" FT /db_xref="UniProtKB/Swiss-Prot:Q9X7C7" FT /protein_id="CAC31652.1" FT /translation="MCPATVLDSILKGVRADVAAREACISLSEIKAAAAAAPAPLDAMA FT ALREPGIGVIAEVKRASPSVGSLATIADPAKLAQAYEDGGARIISVLTEERRFNGSLDD FT LDAVRAAVSVPVLRKDFVVQPYQIHEARAHGADMLLLIVAALDQSALMSMLDRTESLGM FT IALVEVRTEQEADRALKAGAKVIGVNARDLMTLEVDRDCFSRIAPGLPSNVIRIAESGV FT RGPADLLAYAGAGADAVLVGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR" FT misc_feature 166115..166873 FT /note="Pfam match to entry PF00218 IGPS, Indole-3-glycerol FT phosphate synthases, score 339.30, E-value 4.3e-98" FT misc_feature 166259..166303 FT /note="PS00614 Indole-3-glycerol phosphate synthase FT signature" FT CDS 166982..168235 FT /transl_table=11 FT /gene="trpB" FT /gene_synonym="ML1272" FT /product="tryptophan synthase [beta] chain" FT /note="Highly similar to many tryptophan synthases [beta FT chain] (EC 4.2.1.20) involved in tryptophan biosynthesis FT e.g. Mycobacterium tuberculosis RV1612 SW:TRPB_MYCTU FT (O08376) (410 aa); Fasta score E(): 0, 86.7% identity in FT 407 aa overlap and Streptomyces coelicolor SW:TRPB_STRCO FT (O05625) (427 aa); Fasta score E(): 0, 65.2% identity in FT 405 aa overlap. Contains Pfam match to entry PF00291 FT S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. FT Contains PS00168 Tryptophan synthase beta chain FT pyridoxal-phosphate attachment site." FT /db_xref="GOA:Q9CC54" FT /db_xref="HSSP:2WSY" FT /db_xref="InterPro:IPR006654" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC54" FT /protein_id="CAC31653.1" FT /translation="MMPNLSCFSVAISEPTCHDPDSGGHFGGPDGYGGRYVPEALMAVI FT EEVTAAYEKERVNQDFLDLLDKLQANYAGRPSPLYEATRLSEYAGSVRIFLKREDLNHT FT GSHKINNVLGQTLLAQRMGKTRVIAETGAGQHGVATATACALFGLDCVIYMGALDTARQ FT ALNVARMRLLGAEVVSVETGSRTLKDAINDAFRDWVTNADNTYYCFGTASGPHPFPTMV FT RDLQRVIGLETRRQIQYQAGRLPDAVTACIGGGSNAIGIFHAFLDDPGVRLVGFEAAGD FT GVETGRHAATLTGGLPGAFQGTFSYLLQDEDGQTIESHSIAAGLDYPGVGPEHAWLRET FT GRAEYQPITDSEAIEAFRLLCRTEGILPALESAHAVAGALKLASEIGKGAVIVVNLSGR FT GDKDIEAAAKWFGLLGTR" FT misc_feature 167189..168178 FT /note="Pfam match to entry PF00291 S_T_dehydratase, FT Pyridoxal-phosphate dependent enzyme, score 429.60, E-value FT 2.8e-125" FT misc_feature 167282..167311 FT /note="PS00168 Tryptophan synthase beta chain FT pyridoxal-phosphate attachment site" FT CDS 168232..169044 FT /transl_table=11 FT /gene="trpA" FT /gene_synonym="ML1273" FT /product="tryptophan synthase [alpha] chain" FT /note="Highly similar to many tryptophan synthases [alpha FT chain] (EC 4.2.1.20) involved in tryptophan biosynthesis FT e.g. Mycobacterium tuberculosis RV1613 SW:TRPA_MYCTU FT (O06130) (270 aa); Fasta score E(): 0, 86.0% identity in FT 265 aa overlap and Streptomyces coelicolor SW:TRPA_STRCO FT (O68816) (271 aa); Fasta score E(): 0, 46.4% identity in FT 261 aa overlap. Contains Pfam match to entry PF00290 FT trp_syntA, Tryptophan synthase alpha chain." FT /db_xref="GOA:Q9CC53" FT /db_xref="HSSP:1GEQ" FT /db_xref="InterPro:IPR002028" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC53" FT /protein_id="CAC31654.1" FT /translation="MMVLEQSETSRLGPVFDSCRADNRAALIGYLPTGYPDVPTSVDAM FT IELVESGCDIIEVGVPYSDPGMDGPTIARATEVALRGGVRVRDTLAAVEAISQAGGRAV FT VMTYWNPVLRYGVCAFARDLESAGGHGLVTPDLIPDEARQWIAASEKHRLDRIFLVAPS FT STPHRLVTTVGASRGFVYAVSVMGVTGARDAVSQVVPELVARVKAVSDIAVGVGLGVRS FT REQAAQIGGYADGVIVGSALVSALGDGLPRLRALAEELAAGVRQRTFM" FT misc_feature 168307..168960 FT /note="Pfam match to entry PF00290 trp_syntA, Tryptophan FT synthase alpha chain, score 239.80, E-value 3.8e-68" FT CDS 169041..170033 FT /transl_table=11 FT /gene="ML1274" FT /product="possible prolipoprotein diacylglyceryl FT transferase." FT /note="Similar to many prolipoprotein diacylglyceryl FT transferases (EC 2.4.99.-), constituting the first step in FT lipoprotein biosynthesis e.g. Staphylococcus aureus FT SW:LGT_STAAU (P52282) (279 aa); Fasta score E(): 3.3e-12, FT 30.6% identity in 258 aa overlap and Mycobacterium FT tuberculosis RV1614 TR:O06131 (EMBL:Z95554) (468 aa); Fasta FT score E(): 0, 75.5% identity in 322 aa overlap. Contains FT multiple possible membrane spanning hydrophobic domains. FT Contains Pfam match to entry PF01790 LGT, Prolipoprotein FT diacylglyceryl transferase." FT /db_xref="GOA:Q9CC52" FT /db_xref="InterPro:IPR001640" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC52" FT /protein_id="CAC31655.1" FT /translation="MTRMLPGYFPSPPRGVWHLGPLPIRAYALLIILGIVAALVVGGRC FT WEARGGERDVTYDIALWAVPFGLVGGRLYHLATDWRTYFGQNGAGLGAALRIWDGGLGI FT WGAVALGCVGAWLGCRRHRIPLPAFGDALAPGIILAQAIGRLGNYFNQELYGRETTMPW FT GLEVFYRRDPAGYMDPHSLDGVSTGQLAFVVQPTFLYELIWNVLVFFALIYVDRWFTLG FT HGRLFATYVAAYCIGRFCVELLRDDAATHIAGIRINSFTSTFVFIGAVVYIILAPKGRE FT EPENLCRAEYVAREIPEPESATERATVASTYATTTAVPVSADEEFAETN" FT misc_feature 169071..169907 FT /note="Pfam match to entry PF01790 LGT, Prolipoprotein FT diacylglyceryl transferase, score 352.70, E-value 3.9e-102" FT CDS 170030..170266 FT /transl_table=11 FT /gene="ML1275" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CC51" FT /protein_id="CAC31656.1" FT /translation="MNLLKLLNLMQSAKCEPVEDKVEQFTEEEASTIGAESDTDAEDWE FT HRSKAEGVKELVEETWSSSLTSSQTQWHRSMPS" FT CDS 170818..171258 FT /transl_table=11 FT /gene="ML1276" FT /product="conserved membrane protein" FT /note="Similar to several proteins of undefined function FT including: Mycobacterium tuberculosis RV1616 TR:O06133 FT (EMBL:Z95554) (132 aa); Fasta score E(): 0, 68.5% identity FT in 127 aa overlap and Streptomyces coelicolor TR:Q9S2U5 FT (EMBL:AL096884) (148 aa); Fasta score E(): 5.3e-11, 41.4% FT identity in 128 aa overlap. Contains possible membrane FT spanning hydrophobic domains." FT /db_xref="InterPro:IPR018527" FT /db_xref="UniProtKB/TrEMBL:Q9CC50" FT /protein_id="CAC31657.1" FT /translation="MELNQVSRAAQQRRQQDPHRRLYGVAGSGLLLAGAFGYIGFVDPH FT NADLVYPLCLFKLLTGWNCPFCGGLRLMHDLLHGDLAASVSDNVFLLVGIPVLVGWVVL FT RRRLGQSVLPTVALLTITVASIVWTVLRNVPGFPLVPTVYSG" FT CDS 171341..172759 FT /transl_table=11 FT /gene="pykA" FT /gene_synonym="ML1277" FT /product="pyruvate kinase" FT /note="Highly similar to many pyruvate kinases (EC FT 2.7.1.40) including: Mycobacterium tuberculosis RV1617 FT SW:KPYK_MYCTU (O06134) (472 aa); Fasta score E(): 0, 90.7% FT identity in 472 aa overlap and Corynebacterium glutamicum FT SW:KPYK_CORGL (Q46078) (475 aa); Fasta score E(): 0, 71.8% FT identity in 468 aa overlap. Contains Pfam match to entry FT PF00224 PK, Pyruvate kinase. Contains PS00110 Pyruvate FT kinase active site signature." FT /db_xref="GOA:Q9CC49" FT /db_xref="HSSP:1E0T" FT /db_xref="InterPro:IPR018209" FT /db_xref="UniProtKB/TrEMBL:Q9CC49" FT /protein_id="CAC31658.1" FT /translation="MTRRGKIVCTLGPATQSDELIRALVEAGMDVARMNFSHGDYSDHK FT AVYDRVRVASDATGRAVGVLADLQGPKIRLGRFATGSTYWADGETVRITVADCHGSHDR FT VSTTYKNLARDAVVGDRVLVDDGKVGLVVSAIDGDDVVCTVTEGGPVSNNKGMSLPGMH FT VSAPALSDKDIEDLTFALNLGADLVALSFVRSPSDVELVHKAMDRVGRRVPVIAKLEKP FT EAVDNLEAIVLAFDAIMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDS FT MIENSRPTRAEASDVANAVLDGADALMLSEETSVGKYPLAAVKTMSRIVCAVEENSTAA FT PPLTHVPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWP FT EVRSQLAMTWGTETFLVPKMLSTDGMIRQVDKSLLELGRYKRGDLVVIVAGTPPGTVGS FT TNLIHVHRIGEDDV" FT misc_feature 171347..172741 FT /note="Pfam match to entry PF00224 PK, Pyruvate kinase, FT score 522.10, E-value 4e-153" FT misc_feature 171977..172015 FT /note="PS00110 Pyruvate kinase active site signature" FT CDS 172866..173759 FT /transl_table=11 FT /gene="tesB" FT /gene_synonym="ML1278" FT /product="acyl CoA thioesterase II" FT /note="Highly similar to many acyl CoA thioesterases FT including: Escherichia coli SW:TESB_ECOLI (P23911) (285 FT aa); Fasta score E(): 5.6e-26, 32.1% identity in 287 aa FT overlap and Mycobacterium tuberculosis RV1618 TR:O06135 FT (EMBL:Z95554) (300 aa); Fasta score E(): 0, 85.1% identity FT in 288 aa overlap." FT /db_xref="GOA:Q9CC48" FT /db_xref="HSSP:1C8U" FT /db_xref="InterPro:IPR003703" FT /db_xref="UniProtKB/TrEMBL:Q9CC48" FT /protein_id="CAC31659.1" FT /translation="MKRLWEKKTMSDFEELLAVLDLNRVADDLFIGSHPSKNPLRTFGG FT QLVAQSFVASSRTLIRDDLPPSAFSVHFINGGDTAKEIEFHVVRLRDERRFANRRVDAI FT QDGMLLSSAMASYMSGGCGLEHAVEPPEAAEPHTRPPIGELLRGYEQIVQHFVNALQPV FT EWRYVNDPSWVMRNKGQRLAYNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTH FT GLSWGFDRIFAVSANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSGQLIA FT TVVQEGVLKYFPASHR" FT CDS 173929..175200 FT /pseudo FT /transl_table=11 FT /gene="ML1279" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1619 (Best blastx score 351)" FT CDS 175462..175833 FT /pseudo FT /transl_table=11 FT /gene="ML1280" FT /product="short-chain alcohol dehydrogenase family FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0765c (Best blastx score 81)" FT CDS complement(175936..177629) FT /pseudo FT /transl_table=11 FT /gene="cydC" FT /gene_synonym="ML1281" FT /product="ABC transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1620c cydC" FT CDS complement(177713..179269) FT /pseudo FT /transl_table=11 FT /gene="cydD" FT /gene_synonym="ML1282" FT /product="ABC transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1621c cydD" FT CDS complement(179392..180392) FT /pseudo FT /transl_table=11 FT /gene="cydB" FT /gene_synonym="ML1283" FT /product="cytochrome d ubiquinol oxidase subunit II FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT cydB (Best blastx score 722)" FT CDS complement(180427..181731) FT /pseudo FT /transl_table=11 FT /gene="appC" FT /gene_synonym="ML1284" FT /product="cytochrome bd-II oxidase subunit I (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT appC (Best blastx score 1184)" FT CDS complement(182016..182972) FT /pseudo FT /transl_table=11 FT /gene="ML1285" FT /product="C-term similar eukaryotic adenylate/guanylate FT cyclases (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1625c (Best blastx score 272)" FT tRNA complement(183298..183374) FT /gene="leuV" FT /note="tRNA Leu anticodon CAA, Cove score 48.78" FT CDS 183467..184084 FT /transl_table=11 FT /gene="ML1286" FT /product="possible two-component response regulatory FT protein" FT /note="Similar to many proposed two-component response FT regulators including: Streptomyces coelicolor TR:Q9S2J0 FT (EMBL:AL109732) (218 aa); Fasta score E(): 0, 65.3% FT identity in 202 aa overlap and Azotobacter vinelandii FT TR:Q44531 (EMBL:X83602) (192 aa); Fasta score E(): 4.5e-11, FT 30.1% identity in 186 aa overlap. Also highly similar to FT Mycobacterium tuberculosis probable two-component response FT system transcriptional regulator RV1626 TR:O06143 FT (EMBL:Z95554) (205 aa); Fasta score E(): 0, 90.7% identity FT in 205 aa overlap. Contains Pfam match to entry PF00072 FT response_reg, Response regulator receiver domain." FT /db_xref="GOA:Q9CC47" FT /db_xref="HSSP:1TMY" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q9CC47" FT /protein_id="CAC31667.1" FT /translation="MTGPTTDADAATPHRVLIAEDEALIRLDLAEMLRDEGYDIVGEAA FT DGQEAVELAERHKPDLVIMDVKMPRRDGIDAASEIASKRIAPIVVLTAFSQRDLVERAR FT DAGAMAYLVKPFTISDLIPAIALAMSRFSELTALEREVATLADRLETRKLVERAKGLLQ FT VKQGMTEPEAFKWIQRAAMDRRTTMKRVAEVVLETLDTPKDT" FT misc_feature 183560..183841 FT /note="Pfam match to entry PF00072 response_reg, Response FT regulator receiver domain, score 91.00, E-value 2.4e-23" FT CDS complement(184164..185357) FT /pseudo FT /transl_table=11 FT /gene="ML1287" FT /product="lipid carrier protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1627c (Best blastx score 235)" FT repeat_region complement(185483..186410) FT /note="Dispersed repeat, RLEP, copy 18" FT tRNA complement(187551..187636) FT /gene="leuU" FT /note="tRNA Leu anticodon GAG, Cove score 59.66" FT CDS 187749..189152 FT /transl_table=11 FT /gene="ML1288" FT /product="possible peptidase" FT /note="Similar to several members of the ARGE/DAPE/ACY1 FT protein family including: Mycobacterium tuberculosis DapE, FT RV2141C, TR:O06234 (EMBL:Z95388) (448 aa); Fasta score E(): FT 0, 83.9% identity in 448 aa overlap and Streptomyces FT coelicolor putative aminoacylase TR:Q9ZBI7 (EMBL:AL035161) FT (443 aa); Fasta score E(): 0, 47.6% identity in 433 aa FT overlapO. Contains Pfam match to entry PF01546 FT Peptidase_M20, Peptidase family M20/M25/M40. Contains FT PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature FT 1." FT /db_xref="GOA:Q9CC46" FT /db_xref="InterPro:IPR011650" FT /db_xref="UniProtKB/TrEMBL:Q9CC46" FT /protein_id="CAC31669.1" FT /translation="MQKTKVLRSLVVAVVGKVTVTVETDVLVNPSDDVVEVVSRLIRFD FT TTNTGDPETTRGEAECAQWVASQLAEVGYQPEYLESGAPGRGNVFARLAGEDSSRGALL FT IHGHLDVVPAETAEWSVHPFSGAVEGGQVWGRGAIDMKDMVGMMIVVARQLKQAGIAPP FT RDLVFAFVADEEHGGSYGSQWLVDNRPDLFDGVTEAIGEVGGFSLTVPCRNGGERRLYL FT IETAEKGMQWMRLTARGRAGHGSMVHNQNAVTAVAEAVARLGRHQFPLVTTDTVVQFLA FT AISEETGLEFDIGSPDLEGAIEKLGPMARMLKAVLYDTANPTVLKAGYKVNVVPATAEA FT MVDCRILPGRQAAFEAAIDELIGPDVTREWIKDLPPYETAFDGDLVDAMNAAVLAVDPD FT GRTVPYMASGGTDAKAFARLGIRCFGFTPLRLPPELDFTALFHGVDERVSIDALKFGID FT VLAHFLTHC" FT misc_feature 187860..188984 FT /note="Pfam match to entry PF01546 Peptidase_M20, Peptidase FT family M20/M25/M40, score 254.70, E-value 1.2e-72" FT misc_feature 188055..188084 FT /note="PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family FT signature 1" FT CDS 189184..189714 FT /transl_table=11 FT /gene="ML1289" FT /product="conserved hypothetical protein" FT /note="Similar to many proteins of undefined function FT including: Mycobacterium tuberculosis Rv2140c SW:YL40_MYCTU FT (O06235) (176 aa); Fasta score E(): 0, 86.3% identity in FT 175 aa overlap and Escherichia coli SW:YBCL_ECOLI (P77368) FT (183 aa); Fasta score E(): 1.1e-21, 45.3% identity in 161 FT aa overlap. Note this CDS contains a strong Pfam hit to the FT Eukaryotic phosphatidylethanolamine-binding protein motif. FT In Eukaryotes this motif is associated with the binding of FT hydrophobic ligands and nucleotides. Contains Pfam match to FT entry PF01161 PBP, Phosphatidylethanolamine-binding FT protein." FT /db_xref="HSSP:1FUX" FT /db_xref="InterPro:IPR005247" FT /db_xref="UniProtKB/TrEMBL:Q9CC45" FT /protein_id="CAC31670.1" FT /translation="MSLPPDPYAALPKLPSFHLTSDSITDGQPLATPQISGIMGAGGAD FT VSPQLSWSGFPTETCSFAVTVYDPDAPTLSGFWHWAVANLPADVTELPAGVGNDGELPA FT GALTLINDAGMRRYIGAAPPPGHGVHRYYVAVHAVRVQKLNLSEDASPAFLGFNLFQHA FT IARAVIHGTYEQH" FT misc_feature 189205..189702 FT /note="Pfam match to entry PF01161 PBP, FT Phosphatidylethanolamine-binding protein, score -64.60, FT E-value 0.58" FT CDS 189814..191240 FT /pseudo FT /transl_table=11 FT /gene="ML1290" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0336 (Best blastx score 285)" FT repeat_region 190242..191295 FT /note="1054 bp repeat, 100% identical to bases FT 2233397..2234450" FT repeat_region 191486..191535 FT /note="50 bp region associated with only one other copy of FT LEPRPT at 2204517..2204566" FT repeat_region 191536..192788 FT /note="LEPRPT, copy 4. Shares 99 % sequence identity with FT bases 727206..728484." FT CDS complement(191764..191926) FT /pseudo FT /transl_table=11 FT /gene="ML1291" FT /product="putative transposase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2087 (Best blastx score 75)" FT CDS complement(192212..192454) FT /transl_table=11 FT /gene="ML1292" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:O33140" FT /protein_id="CAC31673.1" FT /translation="MYMFEQADVQVPPSTYYTVKQQGFVRAADLTDTYDGKILFDLWMA FT NLPILLCAQALARHYTRRSQLRSRQGDTADVYRRY" FT repeat_region 192729..192788 FT /note="61 bp repeat found at 3'-end of LEPRPT and situated FT 5' to some copies of REPLEP" FT CDS complement(194864..195937) FT /transl_table=11 FT /gene="pyrD" FT /gene_synonym="ML1293" FT /product="dihydroorotate dehydrogenase" FT /note="Highly similar to many dihydroorotate dehydrogenases FT (EC 1.3.3.1) involved in pyrimidine biosynthesis, FT including: Escherichia coli PyrD SW:PYRD_ECOLI (P05021) FT (336 aa); Fasta score E(): 0, 42.3% identity in 333 aa FT overlap and Mycobacterium tuberculosis PyrD (RV2139) FT SW:PYRD_MYCTU (O06236) (357 aa); Fasta score E(): 0, 80.9% FT identity in 351 aa overlap. Contains Pfam match to entry FT PF01180 DHOdehase, Dihydroorotate dehydrogenase. Contains FT PS00912 Dihydroorotate dehydrogenase signature 2. Contains FT PS00911 Dihydroorotate dehydrogenase signature 1." FT /db_xref="GOA:P46727" FT /db_xref="HSSP:1D3G" FT /db_xref="InterPro:IPR001295" FT /db_xref="UniProtKB/Swiss-Prot:P46727" FT /protein_id="CAC31674.1" FT /translation="MMYRVVRRLLFLTPPERIHTLVFAMLRCVTSIAVLRRLLRWVLGP FT TDPVLASTVFGVRFPGPLGLAAGFDKDGMGLLAWGALGFGYAEVGTVTAYPQPGNPAPR FT MFRLPADRALLNRMGFNNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDYRAS FT ARLVGPLASYLVVNVSSPNTPGLRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSE FT IDDITDLAVELRLAGIVATNTTVSRDCLVTPGIDALGAGGISGPPVARRAVEVLRRLYG FT RVGDRLVLISVGGIETADDAWDRITAGASLLQGYTGFIYGGGFWPKHIHDGIARRLHDG FT GFASLRDAVGSATAKSE" FT misc_feature complement(194957..195787) FT /note="Pfam match to entry PF01180 DHOdehase, FT Dihydroorotate dehydrogenase, score 526.50, E-value FT 1.9e-154" FT misc_feature complement(195011..195073) FT /note="PS00912 Dihydroorotate dehydrogenase signature 2" FT misc_feature complement(195626..195685) FT /note="PS00911 Dihydroorotate dehydrogenase signature 1" FT CDS complement(195955..196209) FT /transl_table=11 FT /gene="ML1294" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CC44" FT /protein_id="CAC31675.1" FT /translation="MSNRLAPPRSRLPAGWDAEMSNEYEWVPLHLPSELTTLNASTRLS FT IEAEYCGWELIKVRIYTDGSRRTLLRRNNSRLENTGSDR" FT CDS complement(196209..197255) FT /pseudo FT /transl_table=11 FT /gene="ML1295" FT /product=" (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT orthologue " FT CDS 197340..197675 FT /transl_table=11 FT /gene="ML1296" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT protein RV2137C TR:O06238 (EMBL:Z95388) (137 aa); Fasta FT score E(): 1.3e-28, 75.5% identity in 106 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CC43" FT /protein_id="CAC31677.1" FT /translation="MYRFGMRYLDSMTVTVDRHVAGNEFTVEEISTGIFASGYGQVGDG FT RSFSFHIEHWSLVVEIYRTRLAGLVPQTEEVVPRAIRGLVNIDLTDERSLAAAVRDLVA FT RTLTVSG" FT CDS 197716..198564 FT /transl_table=11 FT /gene="ML1297" FT /product="possible undecaprenol kinase" FT /note="Similar to several proposed undecaprenol kinases or FT bacitracin resistance proteins including: Escherichia coli FT SW:BACA_ECOLI (P31054) (273 aa); Fasta score E(): 3.7e-23, FT 34.0% identity in 265 aa overlap and Mycobacterium FT tuberculosis RV2136C TR:O06239 (EMBL:Z95388) (276 aa); FT Fasta score E(): 0, 82.6% identity in 276 aa overlap. FT Contains multiple possible membrane spanning hydrophobic FT domains." FT /db_xref="GOA:Q9CC42" FT /db_xref="InterPro:IPR003824" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC42" FT /protein_id="CAC31678.1" FT /translation="MTAVSAMSWWQVIVLAVVQGLTEFLPVSSSGHLAIVSRILFTGDA FT GASFTAVSQLGTEVAVLVYFGRDIVRILHAWCRGLTVTLHRTADYWLGWYVIIGTIPIC FT ILGLVCKDEIRSGIRPLWVVATALVAFSGVIAFAEYVGRQNRCIEQLNWRDALVVGVAQ FT TLALIPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSIPDAFHPITEGM FT SATGAQLLVATVIAFVVGLVAVSWLLRFLVQHNLYWFVGYRIVVGVGVLILLAVKTVAA FT T" FT CDS 198561..199313 FT /transl_table=11 FT /gene="ML1298" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein RV2135C TR:O06240 (EMBL:Z95388) (236 FT aa); Fasta score E(): 0, 75.2% identity in 250 aa overlap. FT Also similar, in regions, to several putative FT phosphoglycerate mutases e.g. Escherichia coli FT SW:PMG2_ECOLI (P36942) (215 aa); Fasta score E(): 1.2e-06, FT 27.1% identity in 192 aa overlap. Contains Pfam match to FT entry PF00300 PGAM, Phosphoglycerate mutase family." FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/TrEMBL:Q9CC41" FT /protein_id="CAC31679.1" FT /translation="MTVILLRHGRSTSNTAGVLAGRADGVDLDDRGREQAVGLIDRIAE FT LPIRAVVCSPLLRCRRTINPLAETLCLEPFIDDRLSEVDYGEWTGRSIGDLAKEPLWQV FT VQAHPSAAVFPSGEGLAQVQVRAVAAIREYDRRFTSEHGGDTLWVACTHGDVIKAVIAD FT AFGMHLDSFQRVIADPGSVSVIRYTQLRPFVLHVNHTGAQLSSALRAAMKPSGESHSDS FT CGERSGEIRNEPDAAVPSGDAVLGGSAD" FT misc_feature 198570..199130 FT /note="Pfam match to entry PF00300 PGAM, Phosphoglycerate FT mutase family, score 46.10, E-value 1.3e-11" FT CDS 199391..199981 FT /transl_table=11 FT /gene="ML1299" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein RV2134C TR:O06241 (EMBL:Z95388) (195 FT aa); Fasta score E(): 0, 91.1% identity in 192 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49789" FT /protein_id="CAC31680.1" FT /translation="MARAIHVFRTPDRFVAGTVGQPGNRTFYIQAVHDSRVVSVVLEKQ FT QVAVLAERIGALLLEVHRRFGTPVPPEPAEINDLNPLVMPVDAEFRVGTMGLGWDSEAQ FT TVVVELLAVTDAEFDASVVLDDTDEGPDAVRVFLTPESARQFATRSNRVILAGRPPCPL FT CDEPLDPEGHVCARTNGYKRSALLGPKDDDTEW" FT CDS 199992..200780 FT /transl_table=11 FT /gene="ML1300" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein RV2133C TR:O06242 (EMBL:Z95388) (262 FT aa); Fasta score E(): 0, 79.4% identity in 262 aa overlap." FT /db_xref="GOA:Q9CC40" FT /db_xref="InterPro:IPR000403" FT /db_xref="UniProtKB/TrEMBL:Q9CC40" FT /protein_id="CAC31681.1" FT /translation="MLRNGELTVLGRIRSASNATFLCESTLDQRSVHCVYKPVSGEQPL FT WDFPEGTLAGRELSAYLVSTDLGWNIVPYTVIRDGPAGPGMLQLWVQQPGDVADSAPRS FT GPDMVDLFPADKLQSGYLPVLRSYNYAGDEVILMHADDTQLRRLAVFDVLINNADRKGG FT HILYGLDGHVYGVDHGVSLHVEDKLRTVLWGWAGKPIDNQTLEEVAGLADALSGPLADT FT LAGQITWAEIIALRRRAYAMLDNPVMPGPNRDRAIPWPAF" FT CDS 200819..201634 FT /transl_table=11 FT /gene="ML1301" FT /product="possible inositol monophosphatase family protein" FT /note="Similar to several inositol monophosphatase family FT proteins including: Escherichia coli CysQ SW:CYSQ_ECOLI FT (P22255) (246 aa); Fasta score E(): 9.6e-07, 31.3% identity FT in 217 aa overlap and Mycobacterium tuberculosis CysQ FT protein homolog RV2131C SW:CYSQ_MYCTU (O06244) (267 aa); FT Fasta score E(): 0, 76.0% identity in 271 aa overlap. FT Contains Pfam match to entry PF00459 inositol_P, Inositol FT monophosphatase family. Contains PS00629 Inositol FT monophosphatase family signature 1." FT /db_xref="GOA:P46726" FT /db_xref="InterPro:IPR000760" FT /db_xref="UniProtKB/Swiss-Prot:P46726" FT /protein_id="CAC31682.1" FT /translation="MASHDKRDYQAELTDAALAADLATAAGELLLEIREEIGFDQPRAL FT GDAGDRLANSLLLSRLRAERPGDAVLSEEAHDDRVRLQAGRVWIIDPLDGTREFSTAGR FT TDWAVHIALWQRTTGGVADGRREITDAAVALPARGNRVYRSDTVTAGAVTGGVPNILRI FT AVSATRPPTILHRIRQKLAIEPVAIGSAGAKAMAVVDGDVDAYLHVGGQWEWDSAAPAG FT VVLAAGMHASRLDGSPLRYNQLDPYLPDFVMCRADIAPILLGVIREVWQ" FT misc_feature 201026..201115 FT /note="Pfam match to entry PF00459 inositol_P, Inositol FT monophosphatase family, score 16.70, E-value 0.0011" FT misc_feature 201080..201121 FT /note="PS00629 Inositol monophosphatase family signature 1" FT CDS 201830..202984 FT /transl_table=11 FT /gene="cysS2" FT /gene_synonym="ML1302" FT /product="cysteinyl-tRNA synthase" FT /note="Highly similar to multiple cysteinyl-tRNA FT synthetases including: Escherichia coli SW:SYC_ECOLI FT (P21888) (461 aa); Fasta score E(): 0, 36.8% identity in FT 386 aa overlap and Mycobacterium tuberculosis RV2130C FT SW:SYC2_MYCTU (O33264) (414 aa); Fasta score E(): 0, 85.1% FT identity in 383 aa overlap. Contains Pfam match to entry FT PF01406 tRNA-synt_1e, tRNA synthetases class I (C)." FT /db_xref="GOA:Q49784" FT /db_xref="HSSP:1LI5" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:Q49784" FT /protein_id="CAC31683.1" FT /translation="MSAAVAPTCKATMYVCGITPYDATHLGHAATYLAFDLIHRLWLDL FT GHEVHYVQNVTDVDDPLFERADRNGVDWRDLAEREVALFRDDMASLRILPPHDYVAATE FT TIVEIVELVDKMLVSGAAYVIDDEYPDIYFRADATLQFGYESGYDRDTMLRLYEQSGGD FT PRRPGKNGELDALLWRAARPGEPSWSSPFGPGRPGWHVECAAIALSRIGIGLDIQGGGS FT DLIFPHHEFTAAHAECVRGERRFARHYVHAGMIGWDEHKMSKSRGNLVLVSTLRAQGAP FT PSAIRLGLLAGHYRADRFWSSQLLDDAIARLHRWRTAASMPAGPDVADVIARVRGYLAD FT DLDTPKAIAALDGWVTDALEYGGHDAAAPKLLATAIDALLGVDL" FT misc_feature 201857..202885 FT /note="Pfam match to entry PF01406 tRNA-synt_1e, tRNA FT synthetases class I (C), score 255.80, E-value 5.8e-73" FT CDS 203019..203764 FT /pseudo FT /transl_table=11 FT /gene="ML1303" FT /product="putative oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2129c (Best blastx score 193)" FT CDS complement(204119..205615) FT /transl_table=11 FT /gene="ansP1" FT /gene_synonym="ML1304" FT /product="probable L-asparagine permease" FT /note="Highly similar to many L-asparagine transport FT proteins including: Salmonella typhimurium AnsP FT SW:ANSP_SALTY (P40812) (497 aa); Fasta score E(): 0, 58.7% FT identity in 477 aa overlap and Mycobacterium tuberculosis FT RV2127 SW:ANSP_MYCTU (O33261) (489 aa); Fasta score E(): 0, FT 83.4% identity in 488 aa overlap. Contains multiple FT possible membrane spanning hydrophobic domains. Contains FT Pfam match to entry PF00324 aa_permeases, Amino acid FT permease. Contains PS00218 Amino acid permeases signature." FT /note="Almost identical to the duplicated sequence ML1305" FT /db_xref="GOA:Q49801" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/TrEMBL:Q49801" FT /protein_id="CAC31685.1" FT /translation="MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAIG FT TGLFLGAGGRLAKAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGSFVSYAREFFGE FT KAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFTALPQWTLALLALAVVLVMNLISV FT EWFGELEFWAALIKVCALMAFLVVGTIFLGGRYPVDGHNTGLSLWTSHGGLFPTGVAQL FT IVVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVILLALLLPY FT SAFKASESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNAGLYATGRVMHSIAINGSGP FT KFTARMSKNGVPYGGILLAAVICLCGVALNAFNPGQAFEIVLSVAALGIIAGWGTIVLC FT QLRLHKMAKAGIMRRPRFRMPLAPYSGYLTLAFLFAVLVVMAFDKPIGTWTVASLIVIV FT PALIAGWYSIRKRVMTIARERMGYTGPFPAIANPPVKSSD" FT repeat_region complement(204134..205684) FT /note="1551 bp repeat, identical in sequence to duplicated FT region complement(1554201..1555751)." FT misc_feature complement(204203..205540) FT /note="Pfam match to entry PF00324 aa_permeases, Amino acid FT permease, score 500.20, E-value 1.6e-146" FT misc_feature complement(205349..205441) FT /note="PS00218 Amino acid permeases signature" FT CDS complement(205765..207282) FT /transl_table=11 FT /gene="ansP2" FT /gene_synonym="ML1305" FT /product="probable L-asparagine permease" FT /note="Highly similar to many L-asparagine transport FT proteins including: Salmonella typhimurium AnsP FT SW:ANSP_SALTY (P40812) (497 aa); Fasta score E(): 0, 58.9% FT identity in 477 aa overlap and Mycobacterium tuberculosis FT RV2127 SW:ANSP_MYCTU (O33261) (489 aa); Fasta score E(): 0, FT 83.7% identity in 485 aa overlap. Contains multiple FT possible membrane spanning hydrophobic domains. Contains FT Pfam match to entry PF00324 aa_permeases, Amino acid FT permease. Contains PS00218 Amino acid permeases signature." FT /note="Almost identical to the duplicated sequence ML1304" FT /db_xref="GOA:Q9S379" FT /db_xref="InterPro:IPR004841" FT /db_xref="UniProtKB/TrEMBL:Q9S379" FT /protein_id="CAC31686.1" FT /translation="MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAIG FT TGLFLGAGGRLAKAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGSFVSYAREFFGE FT KAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFTALPQWTLALLALAVVLVMNLISV FT EWFGELEFWAALIKVCALMAFLVVGTIFLGGRYPVDGHNTGLSLWTSHGGLFPTGVAPL FT IVVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVILLALLLPY FT SAFKASESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNAGLYATGRVMHSIAINGSGP FT KFTARMSKNGVPYGGILLAAVICLCGVALNAFNPGQAFEIVLSVAALGIIAGWGTIVLC FT QLRLHKMAKAGIMRRPRFRMPLAPYSGYLTLAFLFAVLVVMAFDKPIGTWTVASLIVIV FT PALIAGWYSIRKRVMTIARERMGYTGPFPAIANPPVQPSERSHSQNP" FT repeat_region complement(205801..207351) FT /note="1551 bp repeat, identical in sequence to duplicated FT region complement(1552534..1554084)." FT misc_feature complement(205870..207207) FT /note="Pfam match to entry PF00324 aa_permeases, Amino acid FT permease, score 502.50, E-value 3.2e-147" FT misc_feature complement(207016..207108) FT /note="PS00218 Amino acid permeases signature" FT CDS complement(207419..208243) FT /transl_table=11 FT /gene="ML1306" FT /product="conserved hypothetical protein" FT /note="Similar to several proteins of unkown function FT including: Mycobacterium tuberculosis RV2125 TR:O33260 FT (EMBL:Z97559) (292 aa); Fasta score E(): 0, 85.0% identity FT in 274 aa overlap and Streptomyces coelicolor TR:Q9S2K6 FT (EMBL:AL109732) (312 aa); Fasta score E(): 1.6e-07, 23.4% FT identity in 278 aa overlap." FT /db_xref="InterPro:IPR008492" FT /db_xref="UniProtKB/TrEMBL:Q9CC38" FT /protein_id="CAC31687.1" FT /translation="MAAFEGWNDASDAASGALEHLNAVWEADPIVEIDDEAYYDYQVNR FT PVIRQVDGVTRELVWPAMRISYCRPPGSDRNVVLMHGVEPNMRWRTFCTELLTIADRLN FT VDTVVILGALLADTPHTRPVPVSGAAYSPESARRFGLEETRYEGPTGIAGVFQDACVAA FT RIPAVMFWAAVPHYVSHPPNPKATVALLRRVEDVLDVEVPLADLPTQAEDWEQAITEIA FT AEDDELAEYVHSLEQRGDAEVDVNDALGKIDGDALAAEFERYLRRRRPGFGR" FT CDS 208451..212071 FT /transl_table=11 FT /gene="metH" FT /gene_synonym="ML1307" FT /product="5-methyltetrahydrofolate-homocysteine FT methyltransferase" FT /note="Highly similar to many FT 5-methyltetrahydrofolate--homocysteine methyltransferases FT (EC 2.1.1.13) involved in methionine biosynthesis, FT including: Escherichia coli MetH SW:METH_ECOLI (P13009) FT (1226 aa); Fasta score E(): 0, 31.6% identity in 1233 aa FT overlap and Mycobacterium tuberculosis RV2124C FT SW:METH_MYCTU (O33259) (1192 aa); Fasta score E(): 0, 88.3% FT identity in 1204 aa overlap." FT /db_xref="GOA:Q49775" FT /db_xref="HSSP:1BMT" FT /db_xref="InterPro:IPR003726" FT /db_xref="UniProtKB/Swiss-Prot:Q49775" FT /protein_id="CAC31688.1" FT /translation="MRVTAANQHQYDTDLLETLAQRVMVGDGAMGTQLQDAELTLDDFR FT GLEGCNEILNETRPDVLETIHRRYFEAGADLVETNTFGCNLSNLGDYDIADKIRDLSQR FT GTVIARRVADELTTPDHKRYVLGSMGPGTKLPTLGHTEYRVVRDAYTESALGMLDGGAD FT AVLVETCQDLLQLKAAVLGSRRAMTQAGRHIPVFVHVTVETTGTMLLGSEIGAALAAVE FT PLGVDMIGLNCATGPAEMSEHLRHLSKHARIPVSVMPNAGLPVLGAKGAEYPLQPDELA FT EALAGFIAEFGLSLVGGCCGTTPDHIREVAAAVARCNDGTVPRGERHVTYEPSVSSLYT FT AIPFAQKPSVLMIGERTNANGSKVFREAMIAEDYQKCLDIAKDQTRGGAHLLDLCVDYV FT GRNGVADMKALAGRLATVSTLPIMLDSTEIPVLQAGLEHLGGRCVINSVNYEDGDGPES FT RFVKTMELVAEHGAAVVALTIDEQGQARTVEKKVEVAERLINDITSNWGVDKSAILIDC FT LTFTIATGQEESRKDGIETIDAIRELKKRHPAVQTTLGLSNISFGLNPSARQVLNSVFL FT HECQEAGLDSAIVHASKILPINRIPEEQRQAALDLVYDRRREGYDPLQKLMWLFKGVSS FT PSSKETREAELAKLPLFDRLAQRIVDGERNGLDVDLDEAMTQKPPLAIINENLLDGMKT FT VGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMEKSDCDFGKGLAKGRIVLATVKGDVH FT DIGKNLVDIILSNNGYEVVNLGIKQPITNILEVAEDKSADVVGMSGLLVKSTVIMKENL FT EEMNTRGVAEKFPVLLGGAALTRSYVENDLAEVYEGEVHYARDAFEGLKLMDTIMSAKR FT GEALAPGSPESLAAEADRNKETERKARHERSKRIAVQRKAAEEPVEVPERSDVPSDVEV FT PAPPFWGSRIIKGLAVADYTGFLDERALFLGQWGLRGVRGGAGPSYEDLVQTEGRPRLR FT YWLDRLSTYGVLAYAAVVYGYFPAVSEDNDIVVLAEPRPDAEQRYRFTFPRQQRGRFLC FT IADFIRSRDLATERSEVDVLPFQLVTMGQPIADFVGELFVSNSYRDYLEVHGIGVQLTE FT ALAEYWHRRIREELKFSGNRTMSADDPEAVEDYFKLGYRGARFAFGYGACPDLEDRIKM FT MELLQPERIGVTISEELQLHPEQSTDAFVLHHPAAKYFNV" FT CDS complement(212099..213156) FT /pseudo FT /transl_table=11 FT /gene="PPE" FT /gene_synonym="ML1308" FT /product="PPE-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT PPE (Best blastx score 241)" FT CDS 213566..213847 FT /transl_table=11 FT /gene="hisE" FT /gene_synonym="ML1309" FT /product="phosphoribosyl-ATP pyrophosphatase" FT /note="Highly similar to several phosphoribosyl-ATP FT pyrophosphatases (EC 3.6.1.31) involved in histidine FT biosynthesis, including: Sulfolobus solfataricus HisE FT SW:HIS2_SULSO (O33776) (94 aa); Fasta score E(): 0.00013, FT 32.5% identity in 83 aa overlap and Mycobacterium FT tuberculosis RV2122C SW:HIS2_MYCTU (O33257) (93 aa); Fasta FT score E(): 2.5e-31, 86.0% identity in 93 aa overlap. FT Contains Pfam match to entry PF01503 PRA-PH, FT Phosphoribosyl-ATP pyrophosphohydrolase." FT /db_xref="GOA:Q49786" FT /db_xref="InterPro:IPR008179" FT /db_xref="UniProtKB/Swiss-Prot:Q49786" FT /protein_id="CAC31690.1" FT /translation="MKQSLAVKTFEDLFAELSERARTRPTDSATVASLDGGIHALGKKI FT LEEAGEVWLAAEHEPKEVLAEEISQLLYWTQVLMISRGLSLDDVYRKL" FT misc_feature 213593..213844 FT /note="Pfam match to entry PF01503 PRA-PH, FT Phosphoribosyl-ATP pyrophosphohydrolase, score 18.40, FT E-value 0.0001" FT CDS 213844..214713 FT /transl_table=11 FT /gene="hisG" FT /gene_synonym="ML1310" FT /product="ATP phosphoribosyltransferase" FT /note="Highly similar to many ATP FT phosphoribosyltransferases (EC 2.4.2.17) involved in FT histidine biosynthesis, including: Sulfolobus solfataricus FT HisG SW:HIS1_SULSO (O33771) (290 aa); Fasta score E(): FT 4e-20, 32.0% identity in 291 aa overlap and Mycobacterium FT tuberculosis RV2121C SW:HIS1_MYCTU (O33256) (284 aa); Fasta FT score E(): 0, 87.8% identity in 287 aa overlap. Contains FT Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP FT pyrophosphohydrolase. Contains Pfam match to entry PF01634 FT HisG, ATP phosphoribosyltransferase. Contains PS01316 ATP FT phosphoribosyltransferase signature." FT /db_xref="GOA:Q49776" FT /db_xref="HSSP:1NH7" FT /db_xref="InterPro:IPR015867" FT /db_xref="UniProtKB/Swiss-Prot:Q49776" FT /protein_id="CAC31691.1" FT /translation="MSMLRVAVPNKGALSEPATEILAEAGYRRRTDPKDLTVVDPVNRV FT EFFFLRPKDIAIYVGSGDLDFGITGRDLVHDSDASVCERLALGFGSSSFRYAGPAGRDW FT TTSDLAGKRIATAYSNLVRKDLVAKGIEATVIRLDGAVEISVQLGVADVIADVVGSGRT FT LSLHDLVAFGEPLCDSEAVLIERGDRGSLDHHETVAARDQLVARVQGVVFGQQYLMLDY FT DCPRSVLDKATLITSGLESPTIAPLAEPGWVAIRALVPRRDINGIMDELAAIGAKAILA FT SDIRFCRF" FT misc_feature 213991..214479 FT /note="Pfam match to entry PF01634 HisG, ATP FT phosphoribosyltransferase, score 258.70, E-value 8.1e-74" FT misc_feature 214270..214335 FT /note="PS01316 ATP phosphoribosyltransferase signature" FT CDS 215013..215301 FT /pseudo FT /transl_table=11 FT /gene="ML1311" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2120c (Best blastx score 151)" FT CDS complement(216753..217637) FT /transl_table=11 FT /gene="ML1312" FT /product="conserved hypothetical protein" FT /note="Highly similar to several proteins of unknown FT function e.g. Mycobacterium tuberculosis RV2119 TR:O33254 FT (EMBL:Z97559) (278 aa); Fasta score E(): 0, 79.9% identity FT in 278 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9S377" FT /protein_id="CAC31693.1" FT /translation="MIDQPKPLRADLCSPRLALSPSRAADFKQCPLLYRFRAIDRLPEA FT PSAAQLLGSVVHTTLQRLYGLPALRRCSDTARSLVESVWNQMIAAERDLDGELDAKQRT FT QLLDEARTLLSGYYRLEDPTRFNPQSCEQRVEVELADGLLLRGFIDRIDVAATGELRVV FT DYKTGKAPPAAQALAEFKAMFQMKFYALTLLHSRGVLPARLRLIYLADSQLLDYAPDRD FT ELLRFGKTLMAIWRTIQFSGETGDFRPNPSRLCGWCPHQEHCPAFGGTPPPYPGWPDHS FT HTEAVSRLTESAA" FT CDS 217711..218556 FT /transl_table=11 FT /gene="ML1313" FT /product="conserved hypothetical protein" FT /note="Highly similar to several proteins of unknown FT function e.g. Mycobacterium tuberculosis RV2118C TR:O33253 FT (EMBL:Z97559) (280 aa); Fasta score E(): 0, 84.0% identity FT in 281 aa overlap." FT /db_xref="GOA:Q9S376" FT /db_xref="HSSP:1I9G" FT /db_xref="InterPro:IPR014816" FT /db_xref="UniProtKB/TrEMBL:Q9S376" FT /protein_id="CAC31694.1" FT /translation="MSATGPFTVGERVQLTDTKGRHYTMSLTPGGEFHTHRGSIAHDGI FT IGLEQGSVVKSSTGALFLVLRPLLIDYVMSMPRGPQVIYPKDAAQIVHEGDIFPGARVL FT EAGAGSGALTCSLLRAVGPQGQVISYELRTDHAEHARRNVSNFFCVSGAEGRLSDNWQL FT IVSDVANSELPDGSVDRVVLDMLAPWEVLDTVSRLVIAGGVLVIYVATVTQLSRAVEAL FT RVQQCWVEPRAWETLQRGWNVVGLAVRPEHLMRGHTAFLILARRLAPGAVAPAPWGRKR FT " FT CDS complement(218670..218963) FT /transl_table=11 FT /gene="ML1314" FT /product="conserved hypothetical protein" FT /note="Highly similar to several proteins of unknown FT function e.g. Mycobacterium tuberculosis RV2117 TR:O33252 FT (EMBL:Z97559) (97 aa); Fasta score E(): 0, 85.6% identity FT in 97 aa overlap." FT /db_xref="InterPro:IPR007546" FT /db_xref="UniProtKB/TrEMBL:Q49798" FT /protein_id="CAC31695.1" FT /translation="MWIGWLEFDVLLGDVHSLKQKRSLIRPVLAELQHKFSVSAAETGS FT HDLYRRAGIGVAMVSSDRSHTVDVLDASERLVAAHPEFELLHVRRGLHHSDD" FT CDS complement(218972..219556) FT /transl_table=11 FT /gene="ML1315" FT /product="probable lipoprotein" FT /note="Highly similar to Mycobacterium tuberculosis FT putative lipoprotein LppK (RV2116) SW:LPPK_MYCTU (O33251) FT (189 aa); Fasta score E(): 1.4e-29, 51.6% identity in 188 FT aa overlap. Contains a possible N-terminal signal sequence FT and an appropriately positioned Prokaryotic membrane FT lipoprotein lipid attachment site. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q49803" FT /db_xref="InterPro:IPR020235" FT /db_xref="UniProtKB/Swiss-Prot:Q49803" FT /protein_id="CAC31696.1" FT /translation="MSRWTHRTFFIALSAIVTTAGFGSSGCAHGNSSTSESAVPSTFPG FT ISSSITAPPATGLPAPEVLTNVLSRLADPNIPGIDKLPLIESATPDSAVTLDKFSNALR FT DNGYLPMTFTANNIAWSNKNPSDVLATISVNIAQTNNSVFSFPMEFTPFPPPQQSWQLS FT KRTADMLLEFGNSSGLTNPAPIKAPTPTPSH" FT misc_feature complement(219476..219508) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 219844..221673 FT /transl_table=11 FT /gene="ML1316" FT /product="probable AAA-family ATPase" FT /note="Highly similar to many AAA ATPase-family proteins FT including: Rhodococcus erythropolis ARC protein TR:O50202 FT (EMBL:AF088800) (591 aa); Fasta score E(): 0, 81.8% FT identity in 588 aa overlap, Methanococcus jannaschii cell FT division cycle protein SW:YB56_METJA (Q58556) (903 aa); FT Fasta score E(): 1.6e-17, 46.8% identity in 250 aa overlap FT and Mycobacterium tuberculosis RV2115C SW:YL15_MYCTU FT (O33250) (609 aa); Fasta score E(): 0, 92.8% identity in FT 609 aa overlap. Contains possible coiled-coils between FT residues 76..98. Contains Pfam match to entry PF00004 AAA, FT ATPases associated with various cellular activities (AAA). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT Contains PS00674 AAA-protein family signature." FT /db_xref="GOA:P46509" FT /db_xref="HSSP:1IY2" FT /db_xref="InterPro:IPR003960" FT /db_xref="UniProtKB/Swiss-Prot:P46509" FT /protein_id="CAC31697.1" FT /translation="MGESERSEAFNPPREAGMSSGDIAELEQLRREIVVLREQLEHAVG FT PHGSVRSVRDVHQLEARIDSLTARNSKLMDTLKEARQQLLALREEVDRLGQPPSGYGVL FT LAAHDDETVDVFTSGRKMRLTCSPNIEVASLRKGQTVRLNEALTVVEAGTFEAVGEVST FT LREVLADGHRALVVGHADEERIVCLAEPLVAENLLDGVPGALNDDSRPRKLRPGDSLLV FT DPKAGYAFERVPKAEVEDLVLEEVPDVSYQDIGGLTRQIEQIRDAVELPFLHKELYREY FT ALRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAEVRGDDAREAKSYFLNIKGPELLNK FT FVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGTGVSSDVETTVVPQLLSE FT IDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAQDIYSKYLTESLP FT VHADDLTEFDGDRAACIKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVMYFKDFNSGA FT MIQNVVDRAKKNAIKSVLETGQPGLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGK FT KGERIVYIRTLVTGKSSSASRAIDTESNLGQYL" FT misc_feature 220705..221292 FT /note="Pfam match to entry PF00004 AAA, ATPases associated FT with various cellular activities (AAA), score 248.40, FT E-value 1e-70" FT misc_feature 220720..220743 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 221068..221124 FT /note="PS00674 AAA-protein family signature" FT CDS complement(221695..221991) FT /pseudo FT /transl_table=11 FT /gene="ML1317" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2114 (Best blastx score 169)" FT CDS complement(222149..223154) FT /pseudo FT /transl_table=11 FT /gene="ML1318" FT /product="possible integral membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2113 (Best blastx score 211)" FT CDS 223278..224539 FT /pseudo FT /transl_table=11 FT /gene="ML1319" FT /product="similar to phytoene dehydrogenase precursor FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3727" FT repeat_region complement(224515..225185) FT /note="Dispersed repeat, RLEP, copy 19" FT misc_feature complement(224707..224739) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT misc_feature complement(224761..224793) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 225517..227061 FT /transl_table=11 FT /gene="ML1320" FT /product="conserved hypothetical protein" FT /note="Highly similar to many proteins of undefined FT function including: Rhodococcus sp. TR:Q53081 (EMBL:U26422) FT (499 aa); Fasta score E(): 0, 83.5% identity in 502 aa FT overlap and Mycobacterium tuberculosis RV2112C TR:O33247 FT (EMBL:Z97559) (554 aa); Fasta score E(): 0, 95.4% identity FT in 504 aa overlap." FT /db_xref="InterPro:IPR011389" FT /db_xref="UniProtKB/TrEMBL:Q49779" FT /protein_id="CAC31701.1" FT /translation="MQRIIGTEVEYGISSPSDPTANPILTSTQAVLAYAAAAGIQRVKR FT TRWDYEVESPLRDARGFDLSRSAGPPPVVDADEVGAANMILTNGARLYVDHAHPEYSAP FT ECTDPLDAVIWDKAGERVMEAAARHVASVPGAAKLQLYKNNVDGKGASYGAHENYLMSR FT QTPFSAIIAGLTPFLVSRQVVTGSGRVGIGPAGDEPGFQLSQRSDYIEVEVGLETTLKR FT GIINTRDEPHADADRYRRLHVIVGDANLAETSTYLKLGTTALVLDLIEEGPVHGIDLTD FT LTLARPVHAVHAISRDASLRATVTLVDGRELTGLALQRIYLDRVAKLVDSRDPDPRAAD FT VVKTWVHVLDQLERDPMDCAELLDWPAKLRLLEGFRQRENLNWSAPRLHLVDLQYSDVR FT LDKGLYNRLVARGSMKRLVNEHQVLRAVNNPPTDTRAYFRGECLRRFSADIAAASWDSV FT IFDLGGDSLVRIPTLEPLRGSKAHVGALLDSVDSAAELVEQLTTKPVDPGKVGLDR" FT CDS 227093..227284 FT /transl_table=11 FT /gene="ML1321" FT /product="conserved hypothetical protein" FT /note="Highly similar to many proteins of undefined FT function found upstream of bacterial proteasome beta FT subunits including: Mycobacterium smegmatis TR:O30517 FT (EMBL:AF009645) (64 aa); Fasta score E(): 6.2e-18, 82.8% FT identity in 64 aa overlap, Rhodococcus sp. TR:Q53082 FT (EMBL:U26422) (64 aa); Fasta score E(): 6.7e-17, 82.8% FT identity in 64 aa overlap and Mycobacterium tuberculosis FT RV2111C TR:O33246 (EMBL:Z97559) (64 aa); Fasta score E(): FT 7.9e-19, 87.5% identity in 64 aa overlap. Note the high FT number of the amino acids Glu, Asp and Gly. Contains a FT possible coiled-coil region." FT /db_xref="InterPro:IPR008515" FT /db_xref="UniProtKB/TrEMBL:Q9ZBE0" FT /protein_id="CAC31702.1" FT /translation="MAQEQTRRGGGGDDDEFTSSTSVGQERREKLTEETDDLLDEIDDV FT LEENAEDFVRAYVQKGGQ" FT CDS 227281..228156 FT /transl_table=11 FT /gene="prcB" FT /gene_synonym="ML1322" FT /product="proteasome [beta]-type subunit 2" FT /note="Highly similar to many proposed 20S proteasome beta FT subunits (EC 3.4.99.46) including: Methanococcus jannaschii FT SW:PRCB_METJA (Q58634) (224 aa); Fasta score E(): 0.00015, FT 29.0% identity in 183 aa overlap, Rhodococcus sp. TR:Q53079 FT (EMBL:U26421) (294 aa); Fasta score E(): 0, 63.5% identity FT in 266 aa overlap and Mycobacterium tuberculosis RV2110C FT TR:O33245 (EMBL:Z97559) (291 aa); Fasta score E(): 0, 81.0% FT identity in 290 aa overlap. Contains Pfam match to entry FT PF00227 proteasome, Proteasome A-type and B-type." FT /db_xref="GOA:Q49780" FT /db_xref="HSSP:1PMA" FT /db_xref="InterPro:IPR001353" FT /db_xref="UniProtKB/TrEMBL:Q49780" FT /protein_id="CAC31703.1" FT /translation="MTRSFPDRLPTNLAFPGISVINQSSFVDLLRRQAPELLPVSLGGG FT QSGGGQQLSHGTTIVVLKYPGGVVIAGDRRSTQGNMIAGRDVRKVYITDDYTATGIAGI FT AAVAVEFARLYAVELEHYEKLEGVPLTFAGKVNRLAIMVRSNLTAAMQGLLALPLLAGY FT DIHAPDPQSAGRIVSFDAAGGWNIEEEGYQSVGSGSIFAKSSIKKLYSQVSDADSALRV FT AIEALYDAADDDSATGGPDLVRGIYPTAVTIGAEGAAEVTESRIAELAREIIESRSRAY FT TLGSFGGSEK" FT misc_feature 227452..227673 FT /note="Pfam match to entry PF00227 proteasome, Proteasome FT A-type and B-type, score 40.30, E-value 9.2e-10" FT CDS 228153..228950 FT /transl_table=11 FT /gene="prcA" FT /gene_synonym="ML1323" FT /product="proteasome [alpha]-type subunit 1" FT /note="Highly similar to many proposed 20S proteasome alpha FT subunits including: Rhodococcus sp. TR:Q53080 (EMBL:U26421) FT (259 aa); Fasta score E(): 0, 65.5% identity in 255 aa FT overlap and Mycobacterium tuberculosis RV2109C TR:O33244 FT (EMBL:Z97559) (248 aa); Fasta score E(): 0, 91.8% identity FT in 244 aa overlap." FT /db_xref="GOA:Q9S375" FT /db_xref="InterPro:IPR001353" FT /db_xref="UniProtKB/TrEMBL:Q9S375" FT /protein_id="CAC31704.1" FT /translation="MSFPYFISPEQAMRERSELARKGIARGRSVVALAYAGGVLFVAEN FT PSRSLQKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYA FT QTLGTIFTEQAKPYEVELCVAEVAHYGETKPPELYRITYDGSINDEPHFMVMGGTTESI FT ANALKESYAENASLTDALGIAVAALRAGSADAAGSDQPTLGVASLEVAVLDANRPRRAF FT RRIIGSGLEALLREKDSKGSKGAQNPKGARDSKNSKSYGESTD" FT CDS 229017..229255 FT /pseudo FT /transl_table=11 FT /gene="ML1324" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2104c (Best blastx score 174)" FT CDS 229341..229778 FT /pseudo FT /transl_table=11 FT /gene="ML1325" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2103c (Best blastx score 404)" FT CDS complement(229821..230324) FT /pseudo FT /transl_table=11 FT /gene="ML1326" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2102 (Best blastx score 126)" FT CDS complement(230530..231237) FT /pseudo FT /transl_table=11 FT /gene="ML1327" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2100 (Best blastx score 212)" FT CDS 231401..232759 FT /transl_table=11 FT /gene="ML1328" FT /product="possible DNA-binding protein" FT /note="Highly similar to many proteins of unknown function FT including: Rhodococcus erythropolis TR:P72263 (EMBL:Z82004) FT (447 aa); Fasta score E(): 0, 89.3% identity in 447 aa FT overlap and Mycobacterium tuberculosis Rv2097c FT SW:YK97_MYCTU (Q10706) (452 aa); Fasta score E(): 0, 94.9% FT identity in 452 aa overlap. Contains a probable FT helix-turn-helix motif at aa 380-401 (Score 1155, SD FT +3.12)" FT /db_xref="InterPro:IPR011389" FT /db_xref="UniProtKB/Swiss-Prot:P54077" FT /protein_id="CAC31709.1" FT /translation="MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSN FT VFLRNGARLYLDVGSHPEYATAECDNLVQLVTHDRAGEWVLEDLLVDAEQRLADEGIGG FT DIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKA FT ATFCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMCETTTML FT KVGTAALMLEMVETGVPFRDFSLDNPIRAIREVSHDITGRRPVRLAGGRQASALDIQRE FT YYTRAFEHLQTREPNVQFEQVVDLWGRQLDAIESQDFAKVDTEIDWVIKRKLFQRYQDR FT DNMELTDPKIAQLDLAYHDIKRGRGVFDLLQRKGLAARVTTDEDIADAVNHPPQTTRAR FT LRGEFISAAQAAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVKRLIASM" FT CDS 232766..233761 FT /transl_table=11 FT /gene="ML1329" FT /product="conserved hypothetical protein" FT /note="Similar to several proteins of undefined function FT including: Rhodococcus erythropolis TR:P72264 (EMBL:Z82004) FT (330 aa); Fasta score E(): 0, 57.2% identity in 327 aa FT overlap and Mycobacterium tuberculosis RV2096C FT SW:YK96_MYCTU (Q10705) (332 aa); Fasta score E(): 0, 80.2% FT identity in 329 aa overlap." FT /db_xref="UniProtKB/Swiss-Prot:P54076" FT /protein_id="CAC31710.1" FT /translation="MATSKVERLVNLVIALLSTRGYMTAEKIRSSVAGYSDSPTVEAFS FT RMFERDKNELRDLGIPLEVGKVSALDPSEGYRINRDAYALPPVELTPDEAAAVAVATQL FT WESQELITATQGALLKLRAAGVDIDPLDTPVVIASSSGVSSLRGSEDFLSILLSAIGSR FT QAVQFPYRPSRAEPYTMRNVEPWGVITENSCWYLVGHDCDRNATRTFRLSRIGSEVAPI FT GPAGAVTVPDGVDLRRIVSDAVAEVSTGATARVWVVDGRATALRHAGRPAGVRRLGGRD FT GQVIELDIGSIDRLARDIAGHGADAVVLEPDALRDDVLIRLRAHAGTGPS" FT CDS 233758..234732 FT /transl_table=11 FT /gene="ML1330" FT /product="possible DNA-binding protein" FT /note="Similar to several including: Bacillus subtilis FT putative transcriptional regulator TR:O34920 FT (EMBL:AF027868) (313 aa); Fasta score E(): 3.9e-05, 22.2% FT identity in 311 aa overlap and Mycobacterium tuberculosis FT RV2095C SW:YK95_MYCTU (Q10704) (316 aa); Fasta score E(): FT 0, 74.2% identity in 322 aa overlap. Contains a probable FT helix-turn-helix motif at aa 24-45 (Score 1309, SD +3.65)" FT /db_xref="UniProtKB/Swiss-Prot:P54075" FT /protein_id="CAC31711.1" FT /translation="MTQLSTRLVRLLNMVPYFQANPRITRAEAAADLGVSAKQLDQDFN FT QLWVCGLPGYGPGDLIDFEFSGDTIEVTFSAGIDRPLQLTSPEAIGLLVALRALANIPG FT VVDPEAVRSAIAKIEAAAVVMGNEATGSVASVDTRPFSESHAVAAVRAAVRDKQALVID FT YYSASHDTLTSRIVDPIRVLLVGDHSYLEAWSREAEGVRLFRFDRIVVARELDEPAAAP FT ETVRKALPDTSFFDDDPLLPSATLWVARSVSWIFEYYPMRQAHELPDGSFQAVMTYASD FT AWMTRLVLGFGSAVQVQAPEALAYRVRNAAVAALESYQVTAQA" FT CDS 234784..235071 FT /transl_table=11 FT /gene="ML1331" FT /product="possible secreted protein" FT /note="Highly similar to several proteins of undefined FT function including: Streptomyces coelicolor putative FT secreted protein TR:Q9RJ68 (EMBL:AL132648) (95 aa); Fasta FT score E(): 5.1e-09, 45.3% identity in 86 aa overlap and FT Mycobacterium tuberculosis RV2094C SW:YK94_MYCTU (Q10703) FT (83 aa); Fasta score E(): 5.2e-21, 68.2% identity in 88 aa FT overlap. Contains a possible N-terminal signal sequence. FT Note codon 8 may offer an alternative translational start FT site. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="GOA:P54079" FT /db_xref="InterPro:IPR006312" FT /db_xref="UniProtKB/Swiss-Prot:P54079" FT /protein_id="CAC31712.1" FT /translation="MSGGKFKVGSLSPWHWVVLVVVVVLLFGAKKLPDAARSLGKSMRI FT FKSELREMQTENQAQASALETPMQNPTVVQSQRVVPPWSTEQDHTEARPA" FT misc_feature 234886..234909 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 235210..236070 FT /transl_table=11 FT /gene="ML1332" FT /product="membrane transport protein" FT /note="Similar to many membrane proteins including: FT Escherichia coli Sec-independent protein translocase FT protein TatC SW:TATC_ECOLI (AJ005830) (258 aa); Fasta score FT E(): 1.6e-17, 33.0% identity in 267 aa overlap and FT Mycobacterium tuberculosis RV2093C SW:YK93_MYCTU (Q10702) FT (308 aa); Fasta score E(): 0, 86.0% identity in 286 aa FT overlap. Contains multiple possible membrane spanning FT hydrophobic domains and a possible N-terminal signal FT sequence. Contains Pfam match to entry PF00902 UPF0032, FT MttB family. Contains PS01218 Uncharacterized protein FT family UPF0032 signature." FT /db_xref="GOA:P54078" FT /db_xref="InterPro:IPR019822" FT /db_xref="UniProtKB/Swiss-Prot:P54078" FT /protein_id="CAC31713.1" FT /translation="MSLIDHLTELRTRLLISLAAIVVTTIFGFIWYSHSIFGLESLGEW FT LRRPYCSLPQSARADISPDGQCRLLATAPFDQFMLRIKVGMAAGIVLASPVWFYQLWAF FT ITPGLYTKERRFTVAFVVPAAVLFAGGTVLAYLVLSKALGFLLIVGSGVQVTALSGDRY FT FGFLLNLLVVFGVSFEFPLLIVMLNIAGLLTYQRLKSWRRGLIFAMFVFAAVFTPGSDP FT FSMTALGAALTVLLELAIQLVRLHDKRRVKHEALIADDEASVIEPPSSIPERSYTATRS FT HDDVT" FT misc_feature 235243..235902 FT /note="Pfam match to entry PF00902 UPF0032, MttB family, FT score 313.30, E-value 3e-90" FT misc_feature 235696..235755 FT /note="PS01218 Uncharacterized protein family UPF0032 FT signature" FT CDS 236095..238857 FT /transl_table=11 FT /gene="helY" FT /gene_synonym="ML1333" FT /product="probable helicase, Ski2 subfamily" FT /note="Highly similar to many proposed Prokaryotic and FT Eukaryotic helicases including: Mycobacterium tuberculosis FT RV2092C SW:HELY_MYCTU (Q10701) (906 aa); Fasta score E(): FT 0, 82.5% identity in 922 aa overlap and Saccharomyces FT cerevisiae ATP-dependent RNA helicase Dob1 SW:MTR4_YEAST FT (P47047) (1073 aa); Fasta score E(): 0, 27.2% identity in FT 972 aa overlap. Contains Pfam match to entry PF00270 DEAD, FT DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop)." FT /db_xref="GOA:Q9ZBD8" FT /db_xref="InterPro:IPR014021" FT /db_xref="UniProtKB/Swiss-Prot:Q9ZBD8" FT /protein_id="CAC31714.1" FT /translation="MTDLAELARFTAELPFSLDDFQQRACAALERGHGVLVCAPTGAGK FT TVVGEFAVHLALAAGGKCFYTTPLKALSNQKYTDLTARYGRNRIGLLTGDQSVNGDSPV FT VVMTTEVLRNMLYADSFALQGLSHVVMDEVHFIADRMRGPVWEEVILHLPDDVRMVSLS FT ATVSNAEEFGGWVQTVRGDTTVVVDEHRPVPLWQHVLVGKRLFDLFDYDSNVDQSPVNP FT NLLRHIAHCREADRMSDWRNPRRRAGRGSGVRPRFYRSLARPEVIAILDAEGLLPAITF FT VFSRFGCDAAVQQCLRSPLRLTSEEERAQIAEVIDHRCGDLADADLAVLGYYEWREGLL FT RGLAAHHAGMLPAFRHAVEELFTAGLVKAVFATETLALGINMPARTVVLERLVKFNGKQ FT HVPLTPGEYTQLTGRAGRRGIDVEGHAVVIWHPSEDTSGPSAVAGLASARTFPLRSSFV FT PSYNMTINLVHWMSPERAHALLEQSFAQYQADRSVVGLVRGIERCTQVLGDISSELGGP FT DAPILEYARLRARIAEMERAQSFVFRLQRKQAANDVLAALRRGDIITITHGRHGGLAVV FT LESARDSSNPRPLVLTEHRWAGRISSADYMGAAAPVGSMTLPKRVEHRQQRVRRDLASA FT LRSAATRLSVPDIGDGVDGDKIGFNDGVLHDPELASLRAQLRRHRSNNAPGLDTQLQQA FT ERYLRIERYNAQLQRKVAAATNSLARTFDRIVGLLIERDFIRGPADDPQVTDDGRLLAR FT IYSESDLLVAECLRTGAWAGLRPAELAAVVSAVLYETRGDDGPGGPVDAEAPTPRLRQA FT LQHTSRLSATLRADEQRHRIALSREPDDGFVGVIYCWARTGDLAAVLAAADASGNGAPL FT SAGDFVRWCRQVLDLLDQLRNAAPEPDLRATAKRAINDVRRGVVAVDAG" FT misc_feature 236116..236688 FT /note="Pfam match to entry PF00270 DEAD, DEAD/DEAH box FT helicase, score 112.90, E-value 8.7e-35" FT misc_feature 236209..236232 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 238922..239740 FT /transl_table=11 FT /gene="ML1334" FT /product="possible conserved membrane protein" FT /note="Highly similar to several e.g. Mycobacterium FT tuberculosis hypothetical protein RV2091C SW:YK91_MYCTU FT (Q10700) (244 aa); Fasta score E(): 0, 62.9% identity in FT 272 aa overlap. Note the product of this CDS contains a FT 7xPGQYG(P/S) repeat region similar to several bacterial FT protein calcium binding domains. Contains a possible FT membrane spanning hydrophobic domain." FT /db_xref="InterPro:IPR008160" FT /db_xref="UniProtKB/TrEMBL:Q9ZBD7" FT /protein_id="CAC31715.1" FT /translation="MSEPQGSDPGKQWQSPGEGVENHSSDQPTQAASPWQQQPSTQDST FT WHPPAYASPECYNYPQLTEPVYPHQYPSATPGYGQPGYFGAQFSQCGIPGQYPQSGSPG FT QYGSPGQYGPPGQYGPPGQYGPPGQYGPPGQYGPPGQYGPPGQYSQQFQPYEQPGTKGF FT VALIGSIAGVIGVLIFAAILVTGFLWPAWLVTTKLDVNKAQASVQQVLTDETNGYGAKN FT VKDVKCNNGADPTVKKGDTFDCSVSIDGMQKRVTVTFQDDKGTYEVGRPQ" FT repeat_region 239221..239364 FT /note="8 copies of 18 bp tandem repeat, Consensus FT CGGCCCGCCTGGCCAGTA" FT repeat_region 239225..239365 FT /note="region containing 7x(C/T)CGCCTGGCCAGTACGGC and FT 1xCCGCCTGGCCAGTAC repeats" FT CDS complement(239758..240691) FT /pseudo FT /transl_table=11 FT /gene="ML1335" FT /product="partially similar to DNA polymerase I FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2090 (Best blastx score 363)" FT CDS 240872..241871 FT /pseudo FT /transl_table=11 FT /gene="pepE" FT /gene_synonym="ML1336" FT /product="cytoplasmic peptidase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pepE (Best blastx score 243)" FT repeat_region complement(244645..245678) FT /note="REPLEP region 8, 3'-end most similar to REPLEP 10" FT repeat_region complement(244772..244799) FT /note="28 bp subsequence of 45 bp REPLEP-associated FT sequence" FT repeat_region complement(244800..245678) FT /note="Dispersed repeat, REPLEP, copy 8" FT repeat_region complement(245880..246634) FT /note="Dispersed repeat, RLEP, copy 20" FT CDS complement(246602..246963) FT /pseudo FT /transl_table=11 FT /gene="ML1337" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2674 (Best blastx score 159)" FT CDS complement(247049..248371) FT /transl_table=11 FT /gene="ML1338" FT /product="possible conserved integral membrane protein" FT /note="Similar to several membrane proteins e.g. FT Mycobacterium tuberculosis RV2673 TR:P71970 (EMBL:Z80225) FT (433 aa); Fasta score E(): 0, 82.0% identity in 434 aa FT overlap and weakly similar to Streptomyces coelicolor FT TR:Q53873 (EMBL:AL031317) (411 aa); Fasta score E(): FT 1.1e-12, 28.3% identity in 410 aa overlap. Contains FT multiple possible membrane spanning hydrophobic domains." FT /db_xref="InterPro:IPR018584" FT /db_xref="UniProtKB/TrEMBL:O05686" FT /protein_id="CAC31719.1" FT /translation="MYGALVTAADSTQTGLRNWLLAVFHPRTHTPSTATIVRSALWPAA FT ILSVLHRSTVITTNGNITDDFKPVYRAVLNFRHGWDIYNEHFDYVDPHYLYPPGGTLLM FT APFGYLPFAPSRYLFILINTGAILIAWYLILRLFKYTLSSVAAPTLLLAMFCTETVTST FT LVFTNINGCIMLLEVLFLWWLINGSEPKTVSQQWWAGGAIGLTLVLKPLLGPLLCLPLL FT NRQWQALVPAIALPVVINLAALPLVSHPMDFFTRTVPYILGTRDYFNSSIEGNGVYFGL FT PTWLIVFLRLLFTVLAICSLWLLNRYYRTRDPLFWFTCSTGVLLLWSWLVLPLAQGYYS FT MMLFPFLMTVVLPNSLIRNWPAWLGIYGFLTLDRWLLFNWMRYGRALEYLKITYGWSLL FT LIVVSTVLCFRYLDAKAENRLDHGIDPAWLTAERERASVNA" FT CDS complement(248391..249968) FT /transl_table=11 FT /gene="ML1339" FT /product="putative secreted protease" FT /note="Highly similar to several proteases including: FT Streptomyces lividans TR:Q54399 (EMBL:L42759) (513 aa); FT Fasta score E(): 2.7e-19, 25.7% identity in 548 aa overlap FT and Mycobacterium tuberculosis RV2672 TR:P71969 FT (EMBL:Z80225) (528 aa); Fasta score E(): 0, 74.4% identity FT in 528 aa overlap. Contains a possible N-terminal signal FT sequence." FT /db_xref="GOA:O05685" FT /db_xref="InterPro:IPR013595" FT /db_xref="UniProtKB/TrEMBL:O05685" FT /protein_id="CAC31720.1" FT /translation="MATVVGMRWHTRSATILVAVTALLVGCVPGLAANPRFATNSGARP FT QGAAATTTPAAGPLLIAAPKKDLSWHDCTSRLFRDAGVAAAPGIQLECADYDSDLDPVN FT GGSGTVTIGAVRARSSQTPRDAGPLVFTTGSDLPSSAQLPVWLSRSGADVVRTHPIVAV FT DRRGIGMSNPIDCRDHYDRQKMRDQAQFESGDDPVANLSDISNTATTNCTDAITPGTSA FT YDNSHAASDIERLRNLWDVPALALIGIGNGAEVALAYAASRPDRVARLILDSPIALGIK FT TEAAAEQQVRGQQAALDTFAAQCVALKCALGPDPKSAVTALLAAAHAGKGPGGASVAAV FT TNAITVSLGFPSGDRVGTTMSLANALAAARSGDANPLTNLIHRSDATQDSDGQFVNDCS FT DALNRPTPDRVRELVVAWGKLYPEFGTVGALNLVKCVHWPTGTTPQPPKNLKIDVMVLD FT VQNDPIVGFEGVAATTAAIINANAASKRVMWQGIGHGASIYSACAVPPIIGYLTSGKLP FT ATDTYCPA" FT CDS complement(249982..250788) FT /transl_table=11 FT /gene="ML1340" FT /product="possible reductase" FT /note="Similar to several including: the C-terminal FT reductase domains of several riboflavin biosynthetic FT proteins e.g. Escherichia coli RibD SW:RIBD_ECOLI (X64395) FT (367 aa); Fasta score E(): 0.0028, 23.8% identity in 227 aa FT overlap. Also similar to Mycobacterium tuberculosis RV2671 FT TR:P71968 (EMBL:Z80225) (258 aa); Fasta score E(): 0, 72.9% FT identity in 251 aa overlap. Contains Pfam match to entry FT PF01872 RibD_C, RibD C-terminal domain." FT /db_xref="GOA:O05684" FT /db_xref="InterPro:IPR002734" FT /db_xref="UniProtKB/TrEMBL:O05684" FT /protein_id="CAC31721.1" FT /translation="MSDFETGPAASTTAGRAAQTPLLMLTSGRYLDDDELSQLYGYPSE FT RAGVWIRANFITSIDGGATADGRTGAMAGPGDRFVFNMLRELADVIVVGAGTVRIENYS FT GAHLPVTKRQQRQARGQSEVPQLAIVTNSGRLDRDMAVFTRTEIAPLVLTCTETAKKLR FT TRLADLAYVVSCSGDDPSKVDETVVLATLQTRGLRRVLTEGGPMLLGSFIQHGMLDELC FT LTIAPLIVGGRARRIATGPEQLLTRMRCAHVLTDDAGYLYTRYVKA" FT misc_feature complement(250033..250641) FT /note="Pfam match to entry PF01872 RibD_C, RibD C-terminal FT domain, score 299.30, E-value 4.6e-86" FT CDS 250854..251925 FT /pseudo FT /transl_table=11 FT /gene="ML1341" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2670c (Best blastx score 1011)" FT CDS complement(251918..252101) FT /pseudo FT /transl_table=11 FT /gene="ML1342" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2669" FT CDS complement(252177..252258) FT /pseudo FT /transl_table=11 FT /gene="ML1343" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2668" FT tRNA complement(253976..254050) FT /gene="valU" FT /note="tRNA Val anticodon GAC, Cove score 88.42" FT tRNA complement(254065..254138) FT /gene="cysU" FT /note="tRNA Cys anticodon GCA, Cove score 68.63" FT tRNA complement(254164..254239) FT /gene="glyT" FT /note="tRNA Gly anticodon GCC, Cove score 89.46" FT tRNA 254418..254492 FT /gene="valT" FT /note="tRNA Val anticodon CAC, Cove score 85.25" FT CDS complement(254582..254842) FT /transl_table=11 FT /gene="ML1344" FT /product="doubtful CDS" FT /note="unknown function, weakly similar, in parts, to FT several transposases e.g. Synechocystis sp. TR:Q55831 FT (EMBL:D64004) (259 aa); Fasta score E(): 2.6, 28.4% FT identity in 88 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CC35" FT /protein_id="CAC31725.1" FT /translation="MSQENWKQAVNWRKSVIEIGHDNLQVHYLRHTCTSWSRRAGTGPD FT TPAEGHGSRIDHRDEYIYVDLFDDDLVDITTALDDVHEGAS" FT CDS 255784..257401 FT /pseudo FT /transl_table=11 FT /gene="ML1345" FT /product="transcriptional regulator (LuxR/UhpA family) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0890c (Best blastx score 327)" FT RBS 257704..257707 FT CDS 257713..260721 FT /transl_table=11 FT /gene="ML1346" FT /product="possible long-chain acyl-CoA synthase" FT /note="Similar to many Prokaryotic and Eukaryotic FT long-chain acyl-CoA synthetases including: Mus musculus FT SW:VLCS_MOUSE (O35488) (620 aa); Fasta score E(): 1.5e-20, FT 24.7% identity in 570 aa overlap and Chromatium vinosum FT poly-beta-hydroxybutyrate polymerase (EC 2.3.1.-) FT SW:PHBC_CHRVI (P45370) (355 aa); Fasta score E(): 4.7e-17, FT 28.2% identity in 348 aa overlap. Also highly similar to FT Mycobacterium tuberculosis hypothetical protein RV1683 FT TR:O33185 (EMBL:Z98268) (999 aa); Fasta score E(): 0, 85.6% FT identity in 1002 aa overlap. Contains Pfam match to entry FT PF00501 AMP-binding, AMP-binding enzyme. Contains PS00120 FT Lipases." FT /db_xref="GOA:Q9CC34" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q9CC34" FT /protein_id="CAC31727.1" FT /translation="MDLNFSIVTRPVERLVATAQNGLEVLRLGGLETGSFPSPSQIVES FT VPMYKLRRYFPPGNRPGQPLLGAPVLMVHPMMMSADMWDVTREEGAVGILHVRGLDPWV FT IDFGSPDKVEGGMRRNLADHIVALSEAVDTVKEVTGNDVHLVGYSQGGMFCYQAAAYRR FT SENIASIVAFGSPVDTLAALPMGIPPNFGVVLANFMADHVFNRLDIPSWLARAGFQMLD FT PLKTVKARVDFVRQLHNREALLSREQQRRFLESEGWIAWSGPAISELLKQFIAHNRMMT FT GGFAVNGQMVTLTDITCPVLAFVGEVDDIGQPASVRGIRRAAPNAEVYESLIRTGHFGL FT VVGSRAAQQSWPTVAEWVCWLAANANKPANIHIMPDQPVEHTASGVAISSRLAHGLGEV FT SETALALARGVADAIVAANRSVHTLAVETVRTLPRLARLGQLNDHTRISLGRIIGEQAH FT DAPRGEFLLFDGRVHTYEAVDRRVNNVVRGLIAVGVRQGDRVGVLMETRPSALVAIAAL FT SRLGAVAVMMRPDADLAASVRIGGATKILTDPANLGVVLAYGRQLTGQVLVLGGGESRD FT LHLPEDALQQNQVIDMEKIDPNAVDLPAWYRPNSGLARDLAFIACSTVGGELVAKQITN FT YRWAVSAFGTASTAALDRRDTVYCLTPLHHESALLVSLGGAVVGGARIALSRGLCSNRF FT VHEVRQYGVTVVSYTWAMLRELVDDPAFVLHGNHPVRLFMGSGMPTGLWERVVEAFAPA FT HVVEFFATVDGQAVLANVSGAKIGSKGRPLPGAGHVELGAYDAEQDLILENDRGFVQVA FT DVNQIGVLLAASRGPIDPTASVKRGVFAPADTWIATEYLLRRDYDGDYWLAGRRSSVVR FT TARGLVYTEPVTDALGFITGVDLAATYSVAVDDRELAVSAVTLLPGAAITAADLTEAVA FT SMPVGLGPDIVHVVPELTLSATYRPIVGALRTAGIPKTGRQVWYFDSASNQFRRMTPGV FT RAELAGKHTHTHA" FT misc_feature 258139..258168 FT /note="PS00120 Lipases" FT misc_feature 259132..260403 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score -193.50, E-value 0.00013" FT CDS 260714..260947 FT /transl_table=11 FT /gene="ML1347" FT /product="conserved hypothetical protein" FT /note="Highly similar to proteins of unknown function from FT Mycobacterium tuberculosis RV1684 TR:O33186 (EMBL:Z98268) FT (74 aa); Fasta score E(): 6.9e-20, 70.1% identity in 77 aa FT overlap and Streptomyces coelicolor TR:CAB88911 FT (EMBL:AL353862) (56 aa); Fasta score E(): 0.0064, 48.2% FT identity in 56 aa overlap." FT /db_xref="InterPro:IPR005651" FT /db_xref="UniProtKB/TrEMBL:Q9CC33" FT /protein_id="CAC31728.1" FT /translation="MLDDLLLSILVCPADRGPLVLVDQGYGAGGQSFYNPRLRRAYRID FT DGIPVLLVDEARDVDDDEHAQLMVQAPTTDPQ" FT CDS complement(260966..261524) FT /pseudo FT /transl_table=11 FT /gene="ML1348" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1685c (Best blastx score 335)" FT CDS complement(261553..262205) FT /pseudo FT /transl_table=11 FT /gene="ML1349" FT /product="probable transmembrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1686c (Best blastx score 406)" FT CDS complement(262283..262969) FT /pseudo FT /transl_table=11 FT /gene="ML1350" FT /product="probable ABC transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1687c (Best blastx score 515)" FT CDS 263120..263764 FT /transl_table=11 FT /gene="ML1351" FT /product="possible 3-methylpurine DNA glycosylase" FT /note="Similar to several DNA-3-methyladenine glycosylases FT from both Prokaryotes and Eukaryotes e.g. Bacillus subtilis FT SW:3MGH_BACSU (P94378) (196 aa); Fasta score E(): 7.7e-13, FT 38.4% identity in 185 aa overlap and Arabidopsis thaliana FT SW:3MG_ARATH (Q39147) (254 aa); Fasta score E(): 1.1e-11, FT 32.0% identity in 194 aa overlap. Also highly similar to FT Mycobacterium tuberculosis RV1688 putative 3-methyladenine FT DNA glycosylase SW:3MGH_MYCTU (O33190) (203 aa); Fasta FT score E(): 0, 78.3% identity in 203 aa overlap. Note codon FT 12 may offer an alternative translational start site." FT /db_xref="GOA:O05678" FT /db_xref="HSSP:1F6O" FT /db_xref="InterPro:IPR003180" FT /db_xref="UniProtKB/Swiss-Prot:O05678" FT /protein_id="CAC31732.1" FT /translation="MRSPRRCKICAVSADQLVVDPVVAAHRLLGATITGRGVCAIVVEV FT EAYGGVPDGPWPDAAAHSYHGRNDRNAVMFGPPGRLYTYCSHGIHVCANVSCGPDGTAA FT AVLIRAGALENGADVARSRRGASVRTVALARGPGNLCSALGITMDDNGIDVFAADSPVT FT LVLNEAQEAMSGPRVGISHAADRPWRLWLPGRPEVSTYRRSPRAPAPGASD" FT CDS 263775..265055 FT /transl_table=11 FT /gene="tyrS" FT /gene_synonym="ML1352" FT /product="tyrosyl-tRNA synthase" FT /note="Highly similar to many tyrosyl-tRNA synthetases (EC FT 6.1.1.1) including: Bacillus stearothermophilus FT SW:SYY_BACST (P00952) (419 aa); Fasta score E(): 0, 50.2% FT identity in 416 aa overlap and Mycobacterium tuberculosis FT SW:SYY_MYCTU (O33191) (424 aa); Fasta score E(): 0, 83.6% FT identity in 426 aa overlap. Contains Pfam match to entry FT PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y). FT Contains PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature." FT /db_xref="GOA:Q49900" FT /db_xref="HSSP:1TYC" FT /db_xref="InterPro:IPR002307" FT /db_xref="UniProtKB/Swiss-Prot:Q49900" FT /protein_id="CAC31733.1" FT /translation="MSSSILNELGWRGLVAQSTDLDALADELRRGPMTVYAGFDPTAPS FT LHVGHLVPLLVLRRFQRAGHRPIVLAGGATGMIGDPRDIGERTLNEAYTVAEWAERIRG FT QLERFVEFDDVAKSRNGAIVVNNLEWTSPMSAIEFLRDVGKHFSINLMLDRDTIRRRLN FT GQGISYTEFSYMLLQANDYAELHQRHGCALQIGGSDQWGNIIAGVRLVRQKLGATVHAL FT TVPLVTAADGAKLGKSTGGGSLWLDPEMTSPYAWYQYFINTSDADVIRYLRWFTFLLPE FT ELVELEQTTVSRPQERAAQRRLATELTVLVHGAAATQAVEHASRALFGQGELARLDEAT FT LATALRETVVAELKPGNPDGIVDLLVASGLSPSRGAARRTIDEGGVLVNNIRIQSEEWT FT PRTSDFLHGRWLVLRRGKRNIAGIERV" FT misc_feature 263877..264572 FT /note="Pfam match to entry PF00579 tRNA-synt_1b, tRNA FT synthetases class I (W and Y), score 321.50, E-value FT 9.7e-93" FT misc_feature 263895..263927 FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT CDS complement(265057..266507) FT /pseudo FT /transl_table=11 FT /gene="ML1353" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1376 (Best blastx score 348)" FT CDS complement(266663..266895) FT /pseudo FT /transl_table=11 FT /gene="ML1354" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1375 (Best blastx score 110)" FT CDS 267871..268413 FT /pseudo FT /transl_table=11 FT /gene="ML1355" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1691 (Best blastx score 306)" FT CDS 268489..269516 FT /pseudo FT /transl_table=11 FT /gene="ML1356" FT /product="probable hydrolase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1692 (Best blastx score 433)" FT CDS 269516..269701 FT /transl_table=11 FT /gene="ML1357" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis RV1693 FT TR:O33195 (EMBL:Z98268) (58 aa); Fasta score E(): 9.7e-13, FT 73.8% identity in 61 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CC31" FT /protein_id="CAC31738.1" FT /translation="MTIDPDQIRAEIDALLAQLPDFADLEDSVSGLSLAQLEEVALRFS FT EVHSVLLQALESAEKG" FT CDS 269709..270518 FT /transl_table=11 FT /gene="tlyA" FT /gene_synonym="ML1358" FT /product="cytotoxin/hemolysin" FT /note="Highly similar to several proposed hemolysins FT including: Mycobacterium ulcerans TlyA TR:CAB83047 FT (EMBL:AJ271681) (281 aa); Fasta score E(): 0, 81.0% FT identity in 268 aa overlap, Treponema hyodysenteriae FT hemolysin A SW:HLYA_TREHY (Q06803) (240 aa); Fasta score FT E(): 2.3e-23, 34.9% identity in 238 aa overlap and FT Mycobacterium tuberculosis TR:Q50760 (EMBL:X98295) (268 FT aa); Fasta score E(): 0, 78.4% identity in 268 aa overlap. FT Contains possible membrane spanning hydrophobic domains." FT /db_xref="GOA:O05676" FT /db_xref="InterPro:IPR002877" FT /db_xref="UniProtKB/TrEMBL:O05676" FT /protein_id="CAC31739.1" FT /translation="MARRVRVDVELVRRGLARSRQQAAKLISAGKVSIDGLPAVKPSTA FT VAITTVLTVADDGERSWVSRGAHKLMGALDTFGIPVAGRCCLDAGASTGGFTEVLLDRG FT AAEVVAVDVGYGQLAWSVRCDPRVIVVERTNVHDLSPELIGGPVDLVVADLSFISLATV FT LSALAGCALPSADIVPMVKPQFEVGKGQVGPGGVVRDLRLRADSVLAVARRATELGWRT FT MDVTASSLPGLSGNVEYFLWLRAQTDLELSTDGLEAAVQRAIAEGPQ" FT CDS 270515..271450 FT /transl_table=11 FT /gene="ML1359" FT /product="conserved hypothetical protein" FT /note="Similar to many proteins of undefined function FT including: Streptomyces coelicolor TR:Q9S219 FT (EMBL:AL109848) (301 aa); Fasta score E(): 0, 54.5% FT identity in 303 aa overlap and Mycobacterium tuberculosis FT RV1695 SW:YG95_MYCTU (O33196) (307 aa); Fasta score E(): 0, FT 87.9% identity in 305 aa overlap. In addition, several FT proteins are similar to a C-terminal region/domain e.g. FT Escherichia coli hypothetical protein SW:YFJB_ECOLI FT (P37768) (292 aa); Fasta score E(): 2.6e-17, 31.8% identity FT in 236 aa overlap. Contains Pfam match to entry PF01513 FT DUF15, Domain of unknown function." FT /db_xref="GOA:Q49897" FT /db_xref="InterPro:IPR002504" FT /db_xref="UniProtKB/Swiss-Prot:Q49897" FT /protein_id="CAC31740.1" FT /translation="MTPRKAAQRTVLLVVHTGRDEATETARRVKKIVGDNGIALRVLSA FT EAVDRGSLHLALDNMRAMGVDIEVVDADPHVAQGCELVLVLGGDGTFLRAAELARTARI FT PVLGVNLGRIGFLAEAEAEAIDVVLEHVIARSYRVEERLTLDIVVRQGGNIIDQGWALN FT EASLEKGPRLGVLGVVVEIEGRPVSTFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAI FT LVVPNNAHALFGRPMVTSPDATVAIELEANGNDALVFCDGRREMIIPAGGRLEVTRCAT FT PVKWARLDSAPFTDRLVSKFRLPVTGWRGK" FT misc_feature 270587..271402 FT /note="Pfam match to entry PF01513 DUF15, Domain of unknown FT function, score 358.50, E-value 7.1e-104" FT CDS 271474..273237 FT /transl_table=11 FT /gene="recN" FT /gene_synonym="ML1360" FT /product="recombination and DNA repair" FT /note="Highly similar to many recombinational repair FT protein (RecN) orthologues including: Bacillus subtilis FT SW:RECN_BACSU (P17894) (576 aa); Fasta score E(): 7.4e-26, FT 30.3% identity in 597 aa overlap and Mycobacterium FT tuberculosis RV1696 TR:O33197 (EMBL:Z98268) (587 aa); Fasta FT score E(): 0, 76.2% identity in 589 aa overlap. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q49896" FT /db_xref="InterPro:IPR004604" FT /db_xref="UniProtKB/Swiss-Prot:Q49896" FT /protein_id="CAC31741.1" FT /translation="MLTEIRIESLGAISVATAEFDRGLTVLTGETGTGKTMVVTGLHLL FT GGARADASRVRSGANRAVVEGRFTTTDLDDVVVAQLDGILNASGSERDEDGSVIVLRSV FT SRDGPSRSYLGGRSVPAKSLGSFTTELLALHGQNDQLRLVRPEEQRAALDRYAAAGPSC FT ERYRELRDAWLLARSDLIDRRNRIRELVQEADRLKFALSEIDSVDPQPGEDNALVADIV FT RLSELDMLREVAVNARAALSGALDDMDVSGSNAVACMGQAKAALESTDDATLRAFADQV FT GEVLTVVVEVGRELGEYLEELPVDASALESKLVRQAELCTLTRKYAADIDGVLQWARES FT RERLEQLDVSYERLAGVESRVDELERQLSQAAVDLSKLRRDAANRLAKEVTAELSALAM FT VDAEFTISVTTDLIPLTDYKRSAAVTLPSGGVARAGADGVDQVEFGFAAHRGMTVLPLA FT KSASGGELSRVMLALEVVLATSAAGTTMVFDEVDVGVGGRAAVQIGRRLARLARTHQVI FT VVTHLPQVAAYADVHLVVHSAGLDGASDVRRLAGDDRVAELARMLAGLGESDSGRAHAR FT ELLDAARKDKS" FT misc_feature 271558..271581 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 273423..274604 FT /transl_table=11 FT /gene="ML1361" FT /product="conserved membrane protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 FT aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. FT Contains possible membrane spanning hydrophobic domain." FT /db_xref="GOA:Q9CC30" FT /db_xref="UniProtKB/TrEMBL:Q9CC30" FT /protein_id="CAC31742.1" FT /translation="MRMSALLSRNNSRPGLVGTARVDRNIDRLLRRICPGDIVVLDVLD FT LDRITADALVEADIVAVVNASPSVSGRYPNLGPEVLVNNGVTLIDETGPEVFKKIKDGA FT KIRLHEGGVYSGDRRLICGTERTDHDIADLMREAKSGLATHLEAFAGNTIEFIKSESPL FT LIDGIGIPDIDVDLRRRHVVIVADEPSAADDLKSLKPFIKEYQPVLVGVSGGADVLRKA FT GYRPQLIVGDPEQISTEALRCGAHVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATD FT LALLLADHHGAALLVTAGHTANIETFFDRTRTQSNPSTFLTRLRVGEKLVDAKAVATLY FT RNHISFGAIALLALIMLIAVIVALWVSRTDGVVLHGVIDYWNRFSLWIQRLIA" FT CDS 274626..275579 FT /transl_table=11 FT /gene="ML1362" FT /product="possible conserved secreted protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1698. Contains a possible N-terminal FT signal sequence." FT /db_xref="GOA:Q49894" FT /db_xref="UniProtKB/Swiss-Prot:Q49894" FT /protein_id="CAC31743.1" FT /translation="MISLRQHAFSLAAVFLALAVGVVLGSGFLSDTLLSSLRDEKRDLY FT TQISGLNDQKNMLNEKVSAANNFDNQLLGRIVHDVLGGTSVVVFRTPDAKDDDVAAVSK FT IVVQAGGTVTGTVSLTQEFVDANSTEKLRSVVNSSILPAGAQLSTKLVDQGSQAGDLLG FT ITLLVNANPAVPNVGDAQRSTVLVALRDTGFITYQTYNRNDHLGAANAALVITGGLLPQ FT DAGNQGVSVARFSAALAPHGSGTLLAGRDGSATGVAAVAVARADAGMAATISTVDNVDA FT EPGRITAILGLHDLLSGGHTGQYGVGHGATSITVPQ" FT RBS 275739..275744 FT CDS 275752..277524 FT /transl_table=11 FT /gene="pyrG" FT /gene_synonym="ML1363" FT /product="CTP synthase" FT /note="Highly similar to many CTP synthases (EC 6.3.4.2), FT catalysing the last step in pyrimidine biosynthesis, FT including: Escherichia coli SW:PYRG_ECOLI (P08398) (544 FT aa); Fasta score E(): 0, 50.5% identity in 548 aa overlap FT and Mycobacterium tuberculosis SW:PYRG_MYCTU (P96351) (586 FT aa); Fasta score E(): 0, 89.2% identity in 590 aa overlap. FT Contains Pfam match to entry PF00117 GATase, Glutamine FT amidotransferase class-I. Contains PS00442 Glutamine FT amidotransferases class-I active site." FT /db_xref="GOA:P53529" FT /db_xref="InterPro:IPR000991" FT /db_xref="UniProtKB/Swiss-Prot:P53529" FT /protein_id="CAC31744.1" FT /translation="MRKHPQSATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQ FT KLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYST FT VIAKERRGEYLGDTVQVIPHITDEIKQRIMAMAQPDGGDNRPDVVITEIGGTVGDIESQ FT PFLEAARQVRHDLGRENVFFLHVSLVPHLAPSGELKTKPTQHSVAALRSIGITPDALIL FT RCDRDVPESLKNKIALMCDVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFR FT DVDWTEWDDLLRRVHEPHGTVRIALVGKYVDFSDAYLSVSEALHAGGFKHYAKVEVVWV FT ASDDCETATGAAAVLADVHGVLIPGGFGIRGIEGKIGAIRYARARGLPVLGLCLGLQCI FT VIEATRSVGLVQANSAEFEPATPDPVISTMADQKEIVAGEADFGGTMRLGAYPAVLQPA FT SIVAQAYGTTQVSERHRHRYEVNNAYRDWIAESGLRISGTSPDGYLVEFVEYPANMHPF FT VVGTQAHPELKSRPTRPHPLFVAFVGAAIDYKSAELLPVEIPAVPEISEHLPNSSNQHR FT DGVERSFPAPAARG" FT misc_feature 276685..277383 FT /note="Pfam match to entry PF00117 GATase, Glutamine FT amidotransferase class-I, score 173.80, E-value 2.8e-48" FT misc_feature 276913..276948 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT CDS 277517..278129 FT /pseudo FT /transl_table=11 FT /gene="ML1364" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1700 (Best blastx score 554)" FT CDS 278138..279088 FT /transl_table=11 FT /gene="ML1365" FT /product="integrase/recombinase" FT /note="Highly similar to several including: Escherichia FT coli integrase/recombinase XerD which is involved in site FT specific recombination, SW:XERD_ECOLI (P21891) (298 aa); FT Fasta score E(): 5.7e-29, 40.3% identity in 308 aa overlap. FT Also similar to several other Mycobacterium tuberculosis FT integrase/recombinases e.g. RV2894C SW:YS94_MYCTU (Q10815) FT (298 aa); Fasta score E(): 0, 42.9% identity in 312 aa FT overlap and RV1701 TR:O33200 (EMBL:Z98268) (311 aa); Fasta FT score E(): 0, 85.9% identity in 311 aa overlap. Contains FT Pfam match to entry PF00589 Phage_integrase, 'Phage' FT integrase family." FT /note="Similar to ML1365" FT /db_xref="GOA:Q49890" FT /db_xref="HSSP:1A0P" FT /db_xref="InterPro:IPR011932" FT /db_xref="UniProtKB/Swiss-Prot:Q49890" FT /protein_id="CAC31746.1" FT /translation="MTTAALQTQLQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDR FT GIEDLAKVGEHDVSEFLVALRRGDPDSGVAALSAVSAARALIAVRGLHRFAVAEGLVDL FT DVARAVRPPTPGRRLPKSLTVDEVLALLESVGGESRADGPLVLRNRALLELLYSTGSRI FT SEAVGLDVDDVDTQARTVLLQGKGGKQRLVPVGRPAVQALDAYLVRGRSDLARRGPGML FT ATPAIFLNARGGRLSRQSAWQVLQDAAEHAGITSGVSPHMLRHSFATHLLEGGADIRVV FT QELMGHASVTTTQIYTLVTVQALREVWAGAHPRAK" FT misc_feature 278486..279055 FT /note="Pfam match to entry PF00589 Phage_integrase, 'Phage' FT integrase family, score 189.10, E-value 6.9e-53" FT CDS complement(279133..279324) FT /pseudo FT /transl_table=11 FT /gene="ML1366" FT /product="putative methyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1703c (Best blastx score 219)" FT RBS 279420..279424 FT CDS 279629..280492 FT /transl_table=11 FT /gene="ML1367" FT /product="possible regulatory protein" FT /note="Similar to several proteins involved in FT plasmid/chromosome partioning or regulation of sporulation FT e.g. Neisseria meningitidis ParA family protein TR:CAB83392 FT (EMBL:AL162752) (257 aa); Fasta score E(): 0, 42.1% FT identity in 252 aa overlap and Bacillus subtilis FT SW:SOJ_BACSU (P37522) (253 aa); Fasta score E(): 0, 46.2% FT identity in 247 aa overlap, respectively. Also highly FT similar to Mycobacterium tuberculosis RV1708 TR:O33207 FT (EMBL:Z98268) (318 aa); Fasta score E(): 0, 89.5% identity FT in 286 aa overlap. Contains Pfam match to entry PF00991 FT ParA, ParA family ATPase. Contains Pfam match to entry FT PF00142 fer4_NifH, 4Fe-4S iron sulfur cluster binding FT proteins, NifH/frxC family." FT /db_xref="GOA:Q9CC29" FT /db_xref="InterPro:IPR002586" FT /db_xref="UniProtKB/TrEMBL:Q9CC29" FT /protein_id="CAC31748.1" FT /translation="MIDHLDSVVEIGLTGRPPRAIPEPRPRSSHGPAKVVAMCNQKGGV FT GKTTSTINLGAALTEFGRRVLLVDIDPQGALSAGLGVPHYELDRTIHNLMVEPLVSIDD FT VLIHTRVRYLDLVPSNIDLSAAEIQLVNEVGREQTLARALHPVLDRYDYVLIDCQPSLG FT LLTVNGLACAEGVVIPTECEFFSLRGLALLTDTVDKVRDRLNPKLEISGILITRYDPRT FT VNAREVMARVVERFGDLVFDTVITRTVRFPETSVAGEPITTWAPKSGGARAYRALACEF FT IDRFGA" FT misc_feature 279752..279832 FT /note="Pfam match to entry PF00142 fer4_NifH, 4Fe-4S iron FT sulfur cluster binding proteins, NifH/frxC family, score FT 17.70, E-value 0.00045" FT misc_feature 279974..280309 FT /note="Pfam match to entry PF00991 ParA, ParA family FT ATPase, score 141.40, E-value 1.6e-38" FT CDS 280489..281295 FT /transl_table=11 FT /gene="ML1368" FT /product="conserved hypothetical protein" FT /note="Similar to many proteins of undefined function e.g. FT Bacillus subtilis SW:YPUG_BACSU (P35154) (251 aa); Fasta FT score E(): 2e-12, 26.0% identity in 242 aa overlap and FT Mycobacterium tuberculosis RV1709 TR:O33208 (EMBL:Z98268) FT (278 aa); Fasta score E(): 0, 78.9% identity in 251 aa FT overlap." FT /db_xref="GOA:Q49888" FT /db_xref="InterPro:IPR003768" FT /db_xref="UniProtKB/TrEMBL:Q49888" FT /protein_id="CAC31749.1" FT /translation="MNSEAPHQNGFQVRLTNFEGPFDLLLHLICAHRLDVTEVALHQVT FT DDFIAYIRRLGPQLGLEETTAFLVIAATLIDLKAARLLPAGRVEDEEDLALLEGRDLLF FT ARLLQYRAFKRVAQIFAELEATALRSYPHAVFLEERFASLLPEVMIGVDADRFAEIAAF FT TFTPRPVPIVATGHLHELKISVPEQAKRLLAMLEARGNGQWTSFSELVADCREPIEVVG FT CFLALLELYRTRAIAFEQAEPLGVLQVSWAGERLASEALAEVRDES" FT RBS 281329..281334 FT CDS 281343..282038 FT /transl_table=11 FT /gene="ML1369" FT /product="conserved hypothetical protein" FT /note="Similar to many proteins of undefined function e.g. FT Streptomyces coelicolor TR:Q9S231 (EMBL:AL109848) (223 aa); FT Fasta score E(): 0, 54.5% identity in 187 aa overlap and FT Mycobacterium tuberculosis RV1710 TR:O33209 (EMBL:Z98268) FT (231 aa); Fasta score E(): 0, 77.9% identity in 231 aa FT overlap." FT /db_xref="GOA:O05669" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:O05669" FT /protein_id="CAC31750.1" FT /translation="MTQEMPDLELDSGIPNIAEASKLDADELGCVLEALLLVVDTPVTV FT EALAAAAEQPVDRIAAKLRLMVNEFAERDSGIDLRHSAEGWRLYTRARYAPYVERLLLD FT GARTKLTRAALETLAVVAYRQPVTRARVSAVRGVNVDAVMRTLLARGLITEVGPEPDSG FT AVMFATTELFLERLGLTSLAELPDIAPLLPDVDTIEDMSEFLDKKPRFIKLTGAKVSKQ FT PRSFDVNQD" FT CDS 282035..282808 FT /transl_table=11 FT /gene="ML1370" FT /product="possible pseudouridine synthase" FT /note="Highly similar to several pseudouridylate synthases FT involved in the modification of ribosomal RNA e.g. Bacillus FT subtilis ribosomal large subunit pseudouridine synthase B FT SW:RLUB_BACSU (P35159) (229 aa); Fasta score E(): 3.6e-30, FT 42.8% identity in 229 aa overlap. Also highly similar to FT Mycobacterium tuberculosis RV1711 SW:YH11_MYCTU (O33210) FT (254 aa); Fasta score E(): 0, 80.2% identity in 257 aa FT overlap. Contains Pfam match to entry PF01479 S4, S4 FT domain. Contains Pfam match to entry PF00849 FT PseudoU_synth_2, RNA pseudouridylate synthase. Contains FT PS01149 Rsu family of pseudouridine synthase signature." FT /db_xref="GOA:O05668" FT /db_xref="HSSP:1KSK" FT /db_xref="InterPro:IPR002942" FT /db_xref="UniProtKB/Swiss-Prot:O05668" FT /protein_id="CAC31751.1" FT /translation="MMVEIHDSRMDRGAGAVRLQKILSRAGIASRRAAEKLIIEGRVEV FT DGQLVRELGTRVDPDVSVVRVDGVKVVVDDSLVYLALNKPRGMYSTMSDDRGRPCVGDL FT IERRVRGNKKLFHVGRLDADTEGLILLTNDGELAHRLMHPSHEVSKTYLATVKGAVPRG FT LGKKLSVGLELDDGPAHVDDFAVVDAIPGKTLVRLTLHEGRKRIVRRLLTAAGFPVEML FT VRTDIGAVSLGDQRPGCLRALLRDEIRQLYKEVGL" FT misc_feature 282083..282223 FT /note="Pfam match to entry PF01479 S4, S4 domain, score FT 61.40, E-value 1.9e-14" FT misc_feature 282266..282676 FT /note="Pfam match to entry PF00849 PseudoU_synth_2, RNA FT pseudouridylate synthase, score 95.00, E-value 1.5e-24" FT misc_feature 282389..282433 FT /note="PS01149 Rsu family of pseudouridine synthase FT signature" FT RBS 282794..282799 FT CDS 282805..283476 FT /transl_table=11 FT /gene="cmk" FT /gene_synonym="ML1371" FT /product="cytidylate kinase" FT /note="Highly similar to several cytidylate kinases (EC FT 2.7.4.14) including: Bacillus subtilis SW:KCY_BACSU FT (P38493) (224 aa); Fasta score E(): 1.9e-28, 42.7% identity FT in 218 aa overlap and Mycobacterium tuberculosis FT RV1712TR:O33211 (EMBL:Z98268) (230 aa); Fasta score E(): 0, FT 74.8% identity in 222 aa overlap. Contains Pfam match to FT entry PF02224 Cytidylate_kin, Cytidylate kinase. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q49885" FT /db_xref="HSSP:1CKE" FT /db_xref="InterPro:IPR011994" FT /db_xref="UniProtKB/Swiss-Prot:Q49885" FT /protein_id="CAC31752.1" FT /translation="MTDIVVAIDGPAGTGKSSVSRGLARELGARYLDTGAMYRMMTLAV FT LRAGIDPADAAAIGESVWKVQMLSDHDRYFLGGEDVSSEIRTEEVTQAVSAVSAIPAVR FT VRLVDLQRQMAEGRGSVVVEGRDIGTVVLPDAPVKIFLTASPETRARRRNDQNVASGSA FT DDYDRVLAEVRRRDHLDSTRAVSPLYVAQDAMIVDTSKMAEAEVIAHLMDLVKQRSGAV FT W" FT misc_feature 282832..282855 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 282979..283443 FT /note="Pfam match to entry PF02224 Cytidylate_kin, FT Cytidylate kinase, score 306.00, E-value 4.4e-88" FT CDS 283470..284858 FT /transl_table=11 FT /gene="ML1372" FT /product="possible GTP-binding protein" FT /note="Highly similar to many proposed Era/ThdF family FT GTP-binding proteins including: Bacillus subtilis FT SW:ENGA_BACSU (P50743) (436 aa); Fasta score E(): 0, 41.0% FT identity in 434 aa overlap and Mycobacterium tuberculosis FT RV1713 SW:ENGA_MYCTU (O33212) (463 aa); Fasta score E(): 0, FT 88.6% identity in 463 aa overlap. Contains Pfam match to FT entry PF01926 MMR_HSR1, GTPase of unknown function. FT Contains 2 x PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="GOA:Q49884" FT /db_xref="HSSP:1MKY" FT /db_xref="InterPro:IPR005225" FT /db_xref="UniProtKB/Swiss-Prot:Q49884" FT /protein_id="CAC31753.1" FT /translation="MVSQDGTWSDESDWELDDSDLAEFGPVVAVVGRPNVGKSTLVNRI FT LGRREAVVQDVPGVTRDRVSYDAMWTGRRFVVQDTGGWEPDAKGLKRLVAEQASVAMRT FT ADAVILVVDVGVGATDADEAAARILLRSGKLVFLAANKVDGEKGESDASALWSLGLGEP FT HAISAMHGRGVADLLDKVLAALPNVAESTSLDGGLRRVALVGKPNVGKSSLLNKLAGDQ FT RSVVHEAAGTTVDPVDSLIEMGGRVWRFVDTAGLRRKVGQASGHEFYASVRTHGAIDSA FT EVVIMLIDASEPLTGQDQRVLSMVIDAGRALVLAFNKWDLVDEDRCDLLEREIDRELVQ FT VRWAQRVNISAKTGRAVQKLVPAMENSLASWDTRIATGPLNIWIKAVVAATPPPVRGGK FT QPRILFATQATARPPTFVLFTTGFLEACYRRFLERRLRETFGFEGSPIRINVRVREKRG FT LKRR" FT misc_feature 283563..283586 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 283749..284528 FT /note="Pfam match to entry PF01926 MMR_HSR1, GTPase of FT unknown function, score 97.90, E-value 2e-25" FT misc_feature 284082..284105 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(284987..286034) FT /pseudo FT /transl_table=11 FT /gene="ML1373" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1945 found within repetitive element belonging to the M. FT tuberculosis degenerate REP13E12 family (Best blastx score FT 97)" FT CDS 286763..287434 FT /pseudo FT /transl_table=11 FT /gene="ML1374" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1716 (Best blastx score 261)" FT CDS 287777..288512 FT /pseudo FT /transl_table=11 FT /gene="ML1375" FT /product="transcriptional regulator (IclR family) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1719 (Best blastx score 433)" FT tRNA 289966..290042 FT /gene="proT" FT /note="tRNA Pro anticodon GGG, Cove score 80.45" FT CDS 291100..292867 FT /pseudo FT /transl_table=11 FT /gene="ML1376" FT /product="probable aminoglycoside 3'-phosphotransferases FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3225c (Best blastx score 314)" FT repeat_region complement(292917..293002) FT /note="86 bp repeat, 97% identical to region FT 1428085..1428170" FT CDS 292992..293457 FT /pseudo FT /transl_table=11 FT /gene="ML1377" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1769 (Best blastx score 218)" FT CDS 293580..294775 FT /pseudo FT /transl_table=11 FT /gene="ML1378" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1770 (Best blastx score 305)" FT CDS 294792..296050 FT /pseudo FT /transl_table=11 FT /gene="ML1379" FT /product="oxidoreductase, possible (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1771 (Best blastx score 462)" FT CDS 296670..297233 FT /transl_table=11 FT /gene="ML1380" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein RV1780 TR:O53931 (EMBL:AL022021) (187 FT aa); Fasta score E(): 0, 82.4% identity in 187 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49881" FT /protein_id="CAC31761.1" FT /translation="MQNYDYLTYEEFGRKFFEVAVTPARVAAAFADIAGNEFSMEPIGQ FT GPGKIAKVSAKVKLREPRVTRHLGDNITFVIRIPLSIDLLVDLRLDKQRFTVAGDIALR FT ATARAAKPLLLMVNVEKPLPSDITVNVSSKSIRGEVLRMLAGIDDEIRRFVAQYVTAEI FT DSPQSQAAQVIDVTHQLEATWADP" FT repeat_region complement(298896..299835) FT /note="Dispersed repeat, RLEP, copy 21" FT CDS complement(299820..302555) FT /transl_table=11 FT /gene="polA" FT /gene_synonym="ML1381" FT /product="DNA polymerase I" FT /note="Highly similar to DNA polymerase I (EC 2.7.7.7) FT (PolI) from many bacteria including: Escherichia coli FT SW:DPO1_ECOLI (P00582) (928 aa); Fasta score E(): 0, 36.4% FT identity in 945 aa overlap and Mycobacterium tuberculosis FT RV1629 SW:DPO1_MYCTU (Q07700) (904 aa); Fasta score E(): 0, FT 85.2% identity in 901 aa overlap. Previously sequenced FT SW:DPO1_MYCLE (P46835) (911 aa); Fasta score E(): 0, 99.9% FT identity in 911 aa overlap. Contains Pfam match to entry FT PF01367 5_3_exonuclease, 5'-3' exonuclease. Contains Pfam FT match to entry PF00476 DNA_pol_A, DNA polymerase family A. FT Contains PS00447 DNA polymerase family A signature." FT /db_xref="GOA:P46835" FT /db_xref="HSSP:1KFD" FT /db_xref="InterPro:IPR008918" FT /db_xref="UniProtKB/Swiss-Prot:P46835" FT /protein_id="CAC31762.1" FT /translation="MSAAMTAEVCEDHTKPMLMLLDGNSLAFRAFYALPTENFKTRGGL FT TTNAVYGFTAMLINLLREEAPTHIAAAFDVSRKTFRSECYAGYKANRSSIPAEFHGQID FT ITKEVLGALGITVFAEAGFEADDLIATLATQAENEGYRVLVVTGDRDALQLVSNDVTVL FT YPRKGVSELTRFTPEAVIEKYGVTPAQYPDLAALRGDPSDNLPGIPGVGEKTAAKWIVD FT YGSLQGLVDNVESVRGKVGEALRTHLASVVRNRELTELVKDVPLVQTSDTLRLQPWDRD FT RIHRLFDNLEFRVLRDRLFEALAAAGERVPEVDEGFDVRGGLLESGTVGRWLAKHADDG FT RRSGLAIVGTHLPHGGDATALAVAAADGNGGYIDTAMLTPDDDDALAAWLADPDNPKAL FT HEAKLAMHDLAGRGWTLGGITSDTALAAYLVRPGQRSFTLDDLSLRYLRRELRAETPEQ FT EQFSLLDNVDEVDKQAIQTLILRARAVVDLAAALDAELDLIDSTSLLGEMELPVQQVLA FT DMEKAGIAADLRLLTELQSQFGDQIRDAAEAAYAVIGKQINLSSPKQLQVVLFEELGMP FT KTKRTKTGYTTDADALQSLFCKTEHPFLQHLLTHRDVTRLKVTVDGLLNAVAADGRIHT FT TFNQTIATTGRLSSTEPNLQNIPIRTNAGRQIRDAFVVGSENNGYTELMTADYSQIEMR FT IMAHLSRDEGLIEAFHTGEDLHSFVASRAFGIPIEDITPELRRRVKAMSYGLAYGLSAY FT GLATQLKISTEEAKLQMEQYFARFGGVRDYLMDVVEQARKDGYTSTVLGRRRYLPELDS FT SNRQIREAAERAALNAPIQGSAADIIKVAMIAVDKSLKQAKLASRMLLQVHDELLFEVA FT IGEREQIEAMVREQMGSAYPLDVPLEVSVGFGRSWGAAAH" FT misc_feature complement(299934..300566) FT /note="Pfam match to entry PF00476 DNA_pol_A, DNA FT polymerase family A, score 365.70, E-value 4.9e-106" FT misc_feature complement(300291..300350) FT /note="PS00447 DNA polymerase family A signature" FT misc_feature complement(301659..302516) FT /note="Pfam match to entry PF01367 5_3_exonuclease, 5'-3' FT exonuclease, score 588.30, E-value 4.7e-173" FT repeat_region 302562..303636 FT /note="Dispersed repeat, RLEP, copy 22" FT CDS 304328..305773 FT /transl_table=11 FT /gene="rpsA" FT /gene_synonym="ML1382" FT /product="30S ribosomal protein S1" FT /note="Highly similar to multiple 30S ribosomal proteins S1 FT including: Escherichia coli SW:RS1_ECOLI (P02349) (557 aa); FT Fasta score E(): 0, 39.1% identity in 471 aa overlap and FT Mycobacterium tuberculosis Rv1630 SW:RS1_MYCTU (O06147) FT (481 aa); Fasta score E(): 0, 93.8% identity in 481 aa FT overlap. Previously sequenced SW:RS1_MYCLE (P46836) (482 FT aa); Fasta score E(): 0, 93.2% identity in 483 aa overlap. FT Contains 4 Pfam matches to entry PF00575 S1, S1 RNA binding FT domain." FT /db_xref="GOA:P46836" FT /db_xref="HSSP:1SRO" FT /db_xref="InterPro:IPR000110" FT /db_xref="UniProtKB/Swiss-Prot:P46836" FT /protein_id="CAC31763.1" FT /translation="MSIPAVPSPQIAVNDVGSSEDFLAAIDKTIKYFNDGDIVEGTIVK FT VDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSK FT KRAQYERAWGTIEALKEKDEAVKGIVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQP FT YIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNQLQKGAIRKGVVSSIVNF FT GAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGNEVTVEVLDVDMDRERVSLSLKATQE FT DPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAV FT GDDAMVKVIDIDLERRRISLSLKQANEDYIEEFDPAKYGMADSYDEQGNYIFPEGFDPD FT SNEWLEGFDTQRAEWEARYAEAERRYKMHTIQMEKFAATEEAGHGSSEQPPASSTPSAK FT ATGGSLASDAQLAALREKLAGSA" FT misc_feature 304421..304642 FT /note="Pfam match to entry PF00575 S1, S1 RNA binding FT domain, score 83.50, E-value 2e-21" FT misc_feature 304682..304891 FT /note="Pfam match to entry PF00575 S1, S1 RNA binding FT domain, score 74.00, E-value 8.3e-19" FT misc_feature 304940..305158 FT /note="Pfam match to entry PF00575 S1, S1 RNA binding FT domain, score 117.90, E-value 1.9e-31" FT misc_feature 305195..305416 FT /note="Pfam match to entry PF00575 S1, S1 RNA binding FT domain, score 111.00, E-value 2.3e-29" FT CDS 305800..307032 FT /transl_table=11 FT /gene="ML1383" FT /product="conserved hypothetical protein" FT /note="Highly similar to many proteins of undefined FT function e.g. Mycobacterium tuberculosis Rv1631 FT SW:YG31_MYCTU (O06148) (407 aa); Fasta score E(): 0, 77.5% FT identity in 409 aa overlap. Contains Pfam match to entry FT PF01121 UPF0038, Uncharacterized protein family UPF0038. FT Contains PS01294 Uncharacterized protein family UPF0038 FT signature." FT /db_xref="GOA:Q50178" FT /db_xref="HSSP:1JJV" FT /db_xref="InterPro:IPR007344" FT /db_xref="UniProtKB/Swiss-Prot:Q50178" FT /protein_id="CAC31764.1" FT /translation="MLCIGITGGIGAGKSLLSSTFSQCGGIVVDGDVLAREVVQPGTKG FT LSSLVDAFGQDILLPGGALDRRALAVKAFRDDAARNVLNGIVHPLVANRRAEIIAAISE FT DAVVVEDIPLLVESGMAHLFPLVVVVHADVELRVRRLVEQRGVAETDARARIAAQASDE FT ERRAVADVWLDNSSTPEVLVQRARDLWYHRILPFAYNLSQRQAVYAPAGLVTSDPIWLG FT QAKRIVARLKTTCGHKALRVDHIGSTAVPHYPGFPDFQAKDIIDIQITVESLAMADELA FT DPLLSAGYPRLEHVTGDAAKTNARSTVDRYEHSSDPNLWHKRFHASADPGRPTYVHIRV FT AGWPNQQFGLLFVDWLKANPGVRADYLDVKRTADRLAAGDMGRYADAKEPWLLDAYRRA FT WEWADSTGWRL" FT misc_feature 305803..306339 FT /note="Pfam match to entry PF01121 UPF0038, Uncharacterized FT protein family UPF0038, score 335.80, E-value 4.9e-97" FT misc_feature 305983..306072 FT /note="PS01294 Uncharacterized protein family UPF0038 FT signature" FT CDS 307825..308163 FT /transl_table=11 FT /gene="ML1384" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CC28" FT /protein_id="CAC31765.1" FT /translation="MTDGIQQFVDIGQSCHGPGANLDVEIMVFRTPHDWARRIFAHIEV FT VVMVAFLARVKVENRGAQAQGWKQPRLEIMELSSAGSGSSNIKPPRLNRVLVDGPDNPF FT GIGVGPGD" FT CDS complement(308290..310790) FT /pseudo FT /transl_table=11 FT /gene="ML1385" FT /product="ABC transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1747 (Best blastx score 280)" FT CDS 311296..312189 FT /pseudo FT /transl_table=11 FT /gene="pknF" FT /gene_synonym="ML1386" FT /product="serine-threonine protein kinase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pknF (Best blastx score 407)" FT RBS 313256..313261 FT CDS 313265..315361 FT /transl_table=11 FT /gene="uvrB" FT /gene_synonym="ML1387" FT /product="excinuclease ABC subunit B" FT /note="Highly similar to many excinucleases ABC (subunit FT B), involved in DNA repair following UV damage, including: FT Micrococcus luteus SW:UVRB_MICLU (P10125) (709 aa); Fasta FT score E(): 0, 71.4% identity in 700 aa overlap and FT Mycobacterium tuberculosis RV1633 SW:UVRB_MYCTU (O06150) FT (698 aa); Fasta score E(): 0, 94.7% identity in 698 aa FT overlap. Contains Pfam match to entry PF00271 helicase_C, FT Helicases conserved C-terminal domain. Contains Pfam match FT to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains FT Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:P57991" FT /db_xref="HSSP:1D9X" FT /db_xref="InterPro:IPR004807" FT /db_xref="UniProtKB/Swiss-Prot:P57991" FT /protein_id="CAC31768.1" FT /translation="MRVGGRFEVISPHEPAGDQPAAIDELQRRILAGERDVVLLGATGT FT GKSATTAWLIERLQRPTLVMAPNKTLAAQLANELRGMLPHNAVEYFVSYYDYYQPEAYI FT AQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRSVEL FT AVSNEVPRDGLLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEI FT EALYYLHPLTGEVIRQVDSLRIFPATHYVAGPERMAQAISAIEEELAERLAEFERQGKL FT LEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDE FT SHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGP FT YELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRANADQRVLVTTLTKK FT MAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVS FT LVAILDADKEGFLRSARSLIQTIGRAARNVSGEVHMYADTITDSMTEAIDETERRRAKQ FT IAYNNANGIDPQPLRKKIADILDQVYREADDTDTVQVGGSGRNVSRGRRAQSEPVRSVS FT VGVFEGRDTAGMPRAELADLIKDLTAQMMAAASDLQFELAARFRDEIADLKKELRGMDA FT AGLK" FT misc_feature 313277..313504 FT /note="Pfam match to entry PF00270 DEAD, DEAD/DEAH box FT helicase, score 19.80, E-value 2.2e-05" FT misc_feature 313385..313408 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 314645..314905 FT /note="Pfam match to entry PF00271 helicase_C, Helicases FT conserved C-terminal domain, score 67.10, E-value 3.8e-16" FT misc_feature 315221..315328 FT /note="Pfam match to entry PF02151 UVR, UvrB/uvrC motif, FT score 50.50, E-value 3.6e-11" FT CDS 315447..316779 FT /pseudo FT /transl_table=11 FT /gene="ML1388" FT /product="probable drug efflux protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1634 (Best blastx score 456)" FT CDS complement(316774..318357) FT /transl_table=11 FT /gene="ML1389" FT /product="conserved membrane protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein RV1635C TR:O06152 (EMBL:Z95554) (556 FT aa); Fasta score E(): 0, 71.6% identity in 528 aa overlap. FT Contains multiple possible membrane spanning hydrophobic FT domains." FT /db_xref="UniProtKB/TrEMBL:Q9CC27" FT /protein_id="CAC31770.1" FT /translation="MTSIMSVSALEQSAADVGDNSARQHAHGALPDSLAIAMLATVISG FT AWASRPSLWFDEAATISASASRTVPELWRLLSHIDAVHGLYYLLMHGWFAIFPSTEFWS FT RVPSCLAIGAAAAGVTVFTRQFATRTTAVYAGIVFAILPRITWAGIEARSSALSVAAAM FT WLTVLLVASVQRNRPRLWLCYALTLMLSILLNLTLATLVLVYAVILPWLAPNKFRNSPF FT IWWAVTSVVALGTITPFILFAHGQVWQVDWIFRVSWHYVFDITQRQYFDHSVSFAIATA FT VIIVPAIATRLAGLRAPAGDLRSLVIICTAWIVIPTTLMVGYSAVIEPVYYPRYLILTA FT PAAAIVIAVCIVTVARKPWPIAGVLVLFAVAAFPNYLFTQRGRYAKEGWDYSQVADVIS FT SQAAPGDCLIVDNTVPWRPGPIRALLAARPAAFRSLIDIERGFYGPTVGTLWDGHVPVW FT LVTAKINKCSTVWTVSDRDTSLPDHQAGQLLSPGLILGRAPAYQFPSYLGFRIVERWQF FT HYSQVIKSTR" FT CDS 318649..319092 FT /transl_table=11 FT /gene="ML1390" FT /product="conserved hypothetical protein" FT /note="Highly similar to several proteins of undefined FT function e.g. Mycobacterium tuberculosis RV1636 TR:O06153 FT (EMBL:Z95554) (146 aa); Fasta score E(): 0, 89.0% identity FT in 146 aa overlap and Neisseria meningitidis TR:AAF41856 FT (EMBL:AE002499) (154 aa); Fasta score E(): 1.7e-07, 32.4% FT identity in 148 aa overlap. Contains Pfam match to entry FT PF00582 Usp, Universal stress protein family." FT /db_xref="GOA:Q9CC26" FT /db_xref="InterPro:IPR006015" FT /db_xref="UniProtKB/TrEMBL:Q9CC26" FT /protein_id="CAC31771.1" FT /translation="MGAYQTVVVGTDGSDSSLRAVDRAGKIAGSDAKLIIASAYLPQHD FT NARAFDILKDESYKVTGTAPIYEILHDAKERAHAAGAKNVEERPVVGAPVDALVNLAEK FT TNADLLVVGNVGLSTIAGRLLGSVPANVSRRAKIDVLIVHTTH" FT misc_feature 318715..319077 FT /note="Pfam match to entry PF00582 Usp, Universal stress FT protein family, score 31.70, E-value 1.7e-05" FT CDS complement(319101..319799) FT /transl_table=11 FT /gene="ML1391" FT /product="conserved hypothetical protein" FT /note="Similar to several including: Streptomyces FT coelicolor putative hydrolase TR:Q9Z505 (EMBL:AL035591) FT (218 aa); Fasta score E(): 0, 50.9% identity in 224 aa FT overlap and in parts to Rhodopseudomonas blastica probable FT hydroxyacylglutathione hydrolase SW:GLO2_RHOBL (P05446) FT (255 aa); Fasta score E(): 2.4e-08, 37.9% identity in 145 FT aa overlap. Also similar to Mycobacterium tuberculosis FT hypothetical protein RV1637CTR:O06154 (EMBL:Z95554) (264 FT aa); Fasta score E(): 0, 84.0% identity in 231 aa overlap. FT Contains Pfam match to entry PF00753 lactamase_B, FT Metallo-beta-lactamase superfamily." FT /db_xref="GOA:Q9CC25" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:Q9CC25" FT /protein_id="CAC31772.1" FT /translation="MTASIDPVNDYTGHVDPGTAARRALPGATILKVSVGPMDNNAYLV FT TCSATGETLLIDAANDAEVLIDLVQRYAPKLSLIVTSHQHFDHWQALEAVVAATGAPTA FT VHELDAEPLPVRPDRLLTNGDCVQIGELTFDVIHLRGHTPGSIALALDGATSGPKTGRV FT TQLFTGDCLFPGGVGKTWQRSDFTQLLDDVTTRVFDVYADTTAIYPGHGDDTVLGAERP FT SLAEWRERGW" FT misc_feature complement(319167..319697) FT /note="Pfam match to entry PF00753 lactamase_B, FT Metallo-beta-lactamase superfamily, score 129.90, E-value FT 4.6e-35" FT RBS 319927..319930 FT CDS 319937..322846 FT /transl_table=11 FT /gene="uvrA" FT /gene_synonym="ML1392" FT /product="excinuclease ABC subunit A" FT /note="Highly similar to many excinucleases ABC (subunit FT A), involved in DNA repair following UV damage, including: FT Micrococcus luteus SW:UVRA_MICLU (P13567) (992 aa); Fasta FT score E(): 0, 69.3% identity in 966 aa overlap and FT Mycobacterium tuberculosis RV1638 SW:UVRA_MYCTU (P94972) FT (972 aa); Fasta score E(): 0, 90.9% identity in 975 aa FT overlap. Contains 2 Pfam matches to entry PF00005 ABC_tran, FT ABC transporter. Contains 2 x PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /db_xref="GOA:Q9CC24" FT /db_xref="InterPro:IPR004602" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC24" FT /protein_id="CAC31773.1" FT /translation="MADRLIVKGAREHNLRSVDLDLPRDSLIVFTGLSGSGKSSLAFDT FT IFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITE FT VYDYLRLLYARAGTPHCPICGEQISRQTPQQIVDQVLVLPEGTRFLVLAPVVRTRKGEF FT ADLFDKLNAQGYSRVRVDDVVYPLSDPPKLKKQEKHDIEVVVDRLTVKIAAKQRLTDSV FT ETALNLADGIVVLEFPDDHDERGHPREQCFSEKLACPNGHPLAVDDLEPRSFSFNSPYG FT ACPECVGLGIRKEIDSDLVVPDPDRTLAEGAVAPWSAGRTAEYFTRMMAGLGEKLGFDV FT DTPWRKLPAKARKAILEGSDHQVHVQYHNRYGRPRSYYVDFEGVLTFLQRKMEQTESEQ FT MKERYEGFMRNIPCPVCQGTRLKPEILAVTLAAGERGAKSIAEVCELSIADCSAFLNAL FT ILGVREQAIAGQVLKEIQSRLGFLLDVGLEYLSLSRAAATLSGGEAQRIRLATQIGSGL FT VGVLYVLDEPSIGLHQRDNRRLIETLTRLRALGNTLIVVEHDEDTIAHADWVVDIGPGA FT GEHGGQIVHNGTYRELLANKDSITGAYLSGRESIATPTRRRSVDRKRELTVVGAREHNL FT RGIDVSFPLGVLTSVTGVSGSGKSTLVNDILAAVLANRLNGARQVPGRHTRVTGLEHLD FT KLVRVDQSPIGRTPRSNPATYTGVFDKIRILFAATTEAKVRGYQPGRFSFNVKGGRCEA FT CTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKAISEVLDMSIEEAAEFFE FT PIIGINRYLRTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTIYILDEPT FT TGLHFDDIRKLLNVINGLVDKDNTVIVIEHNLDVIKTSDWIVDMGPEGGAQGGTVVAEG FT TPEDVAAVPESYTGKFLAEVVGAGCAPARTPRRRRTVTA" FT misc_feature 320009..321661 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 14.40, E-value 1.8e-06" FT misc_feature 320030..320053 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 321869..322684 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 125.60, E-value 9.1e-34" FT misc_feature 321890..321913 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(323523..326642) FT /transl_table=11 FT /gene="lysX" FT /gene_synonym="ML1393" FT /product="C-term lysyl-tRNA synthase" FT /note="The C-terminal region of the predicted product of FT this CDS is highly similar to many lysyl-tRNA synthetases FT (EC 6.1.1.6) including Haemophilus influenzae SW:SYK_HAEIN FT (P43825) (502 aa); Fasta score E(): 0, 40.1% identity in FT 504 aa overlap. The N-terminus is similar to several FT proposed membrane proteins e.g. Streptomyces coelicolor FT TR:O69916 (EMBL:AL023861) (589 aa); Fasta score E(): 0, FT 47.8% identity in 510 aa overlap. This unusual protein is FT conserved in Mycobacterium tuberculosis RV1640C TR:P94974 FT (EMBL:Z85982) (1172 aa); Fasta score E(): 0, 82.0% identity FT in 1041 aa overlap. Contains multiple possible membrane FT spanning hydrophobic domains. Contains Pfam match to entry FT PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and FT N). Contains PS00339 Aminoacyl-transfer RNA synthetases FT class-II signature 2. Contains PS00179 Aminoacyl-transfer FT RNA synthetases class-II signature 1." FT /note="C-terminal similar to ML0233" FT /db_xref="GOA:Q9CC23" FT /db_xref="HSSP:1BBW" FT /db_xref="InterPro:IPR018150" FT /db_xref="UniProtKB/TrEMBL:Q9CC23" FT /protein_id="CAC31774.1" FT /translation="MLALLAAALTTRKRIAWLLLLGNMVLAAVLNAVDMAANGNTPAET FT FGENLGFAVHVVAILLLVLSYREFWAKVRRGALFKAAAVLVAGDVIGILLSLGLVELFP FT GSLARQDRLPYVANRVVGFALADPDLFSGKPHVLLNAIFGLFGALALIMATIVLFQSQR FT ADNALTGEDESAIRGLLELYGKNDSLGYFATRRDKSVIFAHNGRAAITYRVEIGVCLAS FT GDPVGDPGAWPQAVDAWLELCQTYGWAPGVMGASSQGAQVFRRAGFNAIELGDEAILRT FT AVYKLSGPDMRGVRQAVTRARRAGLTVRIRRHSDISANEMADTIARADAWRDTEFERGF FT SMALGRLGDPADSDCLLVEAVDRDDHVVAILSLVPWGTTGVSLDVMRRSPQSPNGTIEL FT MVSELALKGETLGIARISLNFTMFRAAFEQGAQLGAGPIARLWRGLLLFFSRWWQLETL FT YRSNIKYLPDWVPRYACYEDARLIPRVGVASVIAEGFLVLPFSRRGRVHTGHHPAVPAR FT LAESGLLHHDGSTPDVSGLQTADVDLEVANSRIPEQVRVRLAKLKTLQLNGIDAYPVGH FT PPSHTVAQALDADDEGTVSISGRILRIRDYGGVLFAHVRDWSGEIQVLLDNLVLECCCI FT ADFTAAIDLGDIVEMTGNMGFSKNGTRSLIVRNWRLIGKCLRPLPNKWKGLTDPEARVR FT TRYVDLAVNTESRNLIMARSCVLRSVREMLFAKGFVEVETPILQQIHGGATARPFATRI FT NTYDMDLFLRIAPELYLKRLCIGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHAD FT YLMWIDGCRELIQNAAEAANGTQTLMRPRIEGASGTANHLEPIDISGVWPVKTVYEAVS FT EALGECVDTSTELATLRKLSDAAHIPYWPHWDTGAVVLKLYEHLVENRTDQPTFYIDFP FT TSVSPLTRPHRSKPGVAERWDLVAWGIELGTAYSELTDPVEQRRRLHEQSLLAVGGNPE FT AMELDEDFLQAMEYAMPPTGGLGMGIDRLVMLITGRSIRETLPFPLAKPH" FT misc_feature complement(323529..324581) FT /note="Pfam match to entry PF00152 tRNA-synt_2, tRNA FT synthetases class II (D, K and N), score 339.30, E-value FT 4.3e-98" FT misc_feature complement(323580..323609) FT /note="PS00339 Aminoacyl-transfer RNA synthetases class-II FT signature 2" FT misc_feature complement(324228..324281) FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT CDS 327407..327964 FT /transl_table=11 FT /gene="InfC" FT /gene_synonym="ML1394" FT /product="initiation factor 3" FT /note="Highly similar to many translation initiation FT factors (3) including: Neisseria meningitidis TR:AAF41134 FT (EMBL:AE002426) (155 aa); Fasta score E(): 3.8e-28, 48.7% FT identity in 152 aa overlap, Bacillus subtilis SW:IF3_BACSU FT (P55872) (171 aa); Fasta score E(): 1.4e-26, 48.7% identity FT in 150 aa overlap and Mycobacterium tuberculosis RV1641 FT SW:IF3_MYCTU (P94975) (201 aa); Fasta score E(): 0, 89.2% FT identity in 185 aa overlap. Contains Pfam match to entry FT PF00707 IF3, Translation initiation factor IF-3. Contains FT PS00938 Initiation factor 3 signature." FT /db_xref="GOA:Q9CC22" FT /db_xref="HSSP:2IFE" FT /db_xref="InterPro:IPR019814" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC22" FT /protein_id="CAC31775.1" FT /translation="MIGPGGEQVGIVRIEDALRVAADADLDLVEVAPNARPPVCKIMDY FT GKYKYEVAQKARESRRNQQQTVVKEQKLRPKIDDHDYETKKSHVVRFLEAGSKVKVTIM FT FRGREQSRPELGYRLLQRLGADVADYGFVETSAKQDGRNMTMVLAPHRGAKTRASARHP FT EVPGAGSVQDIDATGDTDGSPH" FT misc_feature 327467..327862 FT /note="Pfam match to entry PF00707 IF3, Translation FT initiation factor IF-3, score 294.40, E-value 1e-97" FT misc_feature 327527..327568 FT /note="PS00938 Initiation factor 3 signature" FT CDS 328015..328209 FT /transl_table=11 FT /gene="rpmI" FT /gene_synonym="ML1395" FT /product="50S ribosomal protein L35" FT /note="Highly similar to many 50s ribosomal L35 proteins, FT including: Escherichia coli SW:RL35_ECOLI (P07085) (64 aa); FT Fasta score E(): 2.3e-05, 43.4% identity in 53 aa overlap FT and Mycobacterium tuberculosis RV1642 SW:RL35_MYCTU FT (P94976) (64 aa); Fasta score E(): 1.6e-24, 90.6% identity FT in 64 aa overlap. Contains Pfam match to entry PF01632 FT Ribosomal_L35p, Ribosomal protein L35." FT /db_xref="GOA:Q9CC21" FT /db_xref="InterPro:IPR018265" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC21" FT /protein_id="CAC31776.1" FT /translation="MPKAKTHSGASKRFRRTGTGKIVRQKANRRHLFEHKPSTRTRRLD FT GHTRVSANDTQRVNSLLNG" FT misc_feature 328024..328200 FT /note="Pfam match to entry PF01632 Ribosomal_L35p, FT Ribosomal protein L35, score 105.70, E-value 9e-28" FT CDS 328263..328652 FT /transl_table=11 FT /gene="rplT" FT /gene_synonym="ML1396" FT /product="50S ribosomal protein L20" FT /note="Highly similar to many 50s ribosomal L20 proteins, FT including: Escherichia coli SW:RL20_ECOLI (P02421) (117 FT aa); Fasta score E(): 1.9e-23, 57.8% identity in 116 aa FT overlap and Mycobacterium tuberculosis RV1643 SW:RL20_MYCTU FT (P94977) (129 aa); Fasta score E(): 0, 90.7% identity in FT 129 aa overlap. Contains Pfam match to entry PF00453 FT Ribosomal_L20, Ribosomal protein L20. Contains PS00937 FT Ribosomal protein L20 signature." FT /db_xref="GOA:Q9CC20" FT /db_xref="HSSP:1GYZ" FT /db_xref="InterPro:IPR005812" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC20" FT /protein_id="CAC31777.1" FT /translation="MARVKRAVNAHKKRRTVLKASKGYRGQRSRLYRKAKEQQLHSLGY FT AYRDRRARKGEFRKLWISRINAAARANDITYNRLIQGLKAADVDVDRKNLADIAISDPA FT AFTALVEVARSGLPEDVNVPSGEAA" FT misc_feature 328266..328589 FT /note="Pfam match to entry PF00453 Ribosomal_L20, Ribosomal FT protein L20, score 151.50, E-value 3.5e-47" FT misc_feature 328422..328472 FT /note="PS00937 Ribosomal protein L20 signature" FT CDS 328707..329486 FT /transl_table=11 FT /gene="tsnR" FT /gene_synonym="ML1397" FT /product="putative rRNA methyltransferase" FT /note="Similar to several proposed rRNA methylases (SpoU FT family) e.g. Mycobacterium tuberculosis Rv1644 TR:P94978 FT (EMBL:Z85982) (260 aa); Fasta score E(): 0, 72.8% identity FT in 257 aa overlap and Escherichia coli SW:TRMH_ECOLI FT (P19396) (1436 aa); BlastP Expect 7.5. Contains Pfam match FT to entry PF00588 SpoU_methylase, SpoU rRNA Methylase FT family." FT /db_xref="GOA:Q9CC19" FT /db_xref="InterPro:IPR013123" FT /db_xref="UniProtKB/TrEMBL:Q9CC19" FT /protein_id="CAC31778.1" FT /translation="MLTERSARVVAAVKLHRQVARRRVRRFLAEGPNLVEAAIVSGLVR FT DVFVTEVAAQRHATVLATLKCPVHPVSERAAKALSDTVTPTGLIAVCEMPTTRLATVLA FT GSPQLVVAAVEISEPGNAGTVIRIADAMGAAAVIFGGYTVDPYNGKCLRSSAGSIFSIT FT VVVASDAYAAVTELRAAGLQVLATMVDGETSLDEAKPLLGKPTAWLFGSEPHGLSTEIA FT EAADYRVRIPMVGGVESLNVAATAAICLYQSSRALRL" FT misc_feature 329028..329459 FT /note="Pfam match to entry PF00588 SpoU_methylase, SpoU FT rRNA Methylase family, score 112.60, E-value 7.8e-30" FT CDS complement(329643..330654) FT /pseudo FT /transl_table=11 FT /gene="ML1398" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1645c (Best blastx score 740)" FT CDS 330814..331788 FT /transl_table=11 FT /gene="ML1399" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein RV1647 TR:P94982 (EMBL:Z85982) (316 FT aa); Fasta score E(): 0, 74.0% identity in 312 aa overlap." FT /db_xref="GOA:Q9CC18" FT /db_xref="InterPro:IPR001054" FT /db_xref="UniProtKB/TrEMBL:Q9CC18" FT /protein_id="CAC31780.1" FT /translation="MPPSAKSTYPGQVEGAPHDGTPSAPQEPDEDTVTVPAPALIRRSS FT VSMPNAAQWLHTTNRSPRLVAMVRRARRLLPGDPDFGDPLSTAGEGGPRAAARAADRLL FT GDRGAASREVSLSVLQVWQALTEAIARRPVNPEVTLVFTDLVGFSGWSLQAGDEATLAL FT LRQVARAVESPLLDAGGHIVKRMGDGIMAVFRDPSVAVQAVLAATEAMKSVEVGGYTPR FT IRVGIHTGRPQRLAADWLGVDVNIAARVMERATKGGIMISGPTLDLIPQSDLKELGIIT FT RRVRKPMFTSKFTGIPPDMVIYRIKARRELTASDETAQTNSLT" FT CDS 331832..332255 FT /pseudo FT /transl_table=11 FT /gene="ML1400" FT /product="possible membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1648 (Best blastx score 139)" XX SQ Sequence 332450 BP; 65841 A; 90012 C; 102508 G; 74089 T; 0 other; cggttgggca cgtttctcgt tgtcctcgac gcatcatgcg gcaccgtggt tcgggtggtg 60 gacaatgcgg gacatgatgc atatcggggg agcccgacgt tggggcgtga gatttcgcgt 120 cagacgtttc tgtggggtgc cgctgggagc accggtctcc ggcgcagttt ttggatcgag 180 ccgagtcggt tcggaccggg ttctagccgt tccaaacagt tccgtttgag acgctctttc 240 tttttgccgc cctcagtgaa aaaagtgtta cgacccggcg acggtctcca attcgtagcg 300 gccaagcagg tgttcaacac taaactgcaa tggctcggtg ccggcgataa tagtcaccgc 360 tacatcgacg acggacgtgc aaaaggcgat ggcgttcgcc gcaggccacc agctcaaggt 420 tgccgcacgc cctaggggct ggatgtcaat tacccgacat gtgagcctgc tctgtgatcg 480 attgacgtcg ttatcggtat tgctgttcag tggccagctg gtcaccgcat ccgccaccca 540 caaccccgat ggcttgctct gggcgttgcg cggcagcggt ggctgctacg tcgggggaac 600 aatctcgttg acctttgctg cgttccccac cagggacttc gacgtggtga acctcaattt 660 cccgccgcaa gcgttcgcct caggtcttgc tcggttggcc aaacaggtta cgtatcgccg 720 accaaagcag ctgggcgctg gcagactcca caatcaacct gctgggcacg gcattgccgt 780 atcatcgcga cttgccccgg tcaggtaggg tagcagcgtg gcggaggaca tcagttcagc 840 attgaggtgc aactgacagg gtctaaaagc catgccatcc aattacttgg acctgaccaa 900 gtagctggac ggcggaacct caacccccat cgcttttggt atttgcttag tctatccgat 960 gtcttgccca ccgtcaacgc ggttgttgcc taaaagattg tttcggttgt cgaggtattt 1020 ccgcatggtg tgtgccgtgc gttggtgctc atgcacgacc tcgatggcgt tcggttggtg 1080 ttgtgccggg gccaccgctt ttccgtggtg ccggcaatcc gcgctggtgt tgtgctatgt 1140 ggaagcatcc ggggacccgt cggcagcgac cagctgacgt tgcgacactt tggcacgaat 1200 atattccggc tgagcgctgt acggcagaag tatgatttcc accgagccat gttctccgga 1260 ctgattttct aggcctcgcc gagtgtaagc caggtttggc ggctcaaatg tgccacgcca 1320 ggttgggtgg gattaccgtg ttcgtgcagc gtcacggtct cacctaaacg ccattgggcg 1380 cactcgtttt cgcttgtaag ttgcagcgct atcgctgttg ctaacaccgg gcccgggtgt 1440 gacttggcta gctcgcacaa tcgggtagcc tcgttgaccg actcgccgat cacggcgtgc 1500 ttaaatcttt ctttggcgcc gacattgctg gctccgacct ggccctgccg ctacgttgat 1560 gccggtctga tactcagata tttcattggc cagacggtcg gcgatagtgc gagcggcggg 1620 ccaacacttt cgtcttcggg atggtcgagg tgattcgggg ccccgaagat tgctagcgac 1680 gcttcactct cgaatttatt gaccagtcca tgctggctag gtccaggtaa cttcttggac 1740 gacgatcgcg aaaaaccttt tgaggcaagg caactacatt ggccgcaggc cggctagcca 1800 cccactgagt gtagccgaat atcgatatgg tgctcttctc cgcctagttt cggtcgctcg 1860 cgttccatgg cggcgacttc gcgccctaat tatgtcggcc gaaaaggttc ctcaccggtt 1920 cgaattcaca caatccatcg actatacaat tcaacctatg ctgtagctca ccgatttcga 1980 tgctgtcgaa tcccaccaga ttaccctgca aatcgctgtg cttaaatgct atcgcagtca 2040 gccagaccag gacatcacat ccgcagaaag ctgtaaggtc aatgttgccg ttgacacggc 2100 tcacacgttc gtcacgcact gtacccgggt cagactacgc tgcaatattg cgaagatccg 2160 ttagcagggc gatgccgatg actggcacga atcgattagc cacactgtca tgggccggac 2220 atgattccca tccttaatcg ctgtggcggc agtccggtct tgagtgcctg agcccccact 2280 gggtgcagcg ttcacttggt gaataggtaa ttgcctgtgc tgaccaatac gcagcaaaag 2340 cttactgcga acaggaagct caggatgaac aacatggtgt tcaccagagc catagagtat 2400 cgtgaacaga gctgagccta cccagccaca ggaggaagtc gactatcccg actcgccatg 2460 gtatccggaa cgtgttccac gcgtcgttgc ggatgggttt gcgctccatt gatcacccag 2520 tgggggccag cacggtgcct cctcggcaac gataatgtat gcgcccaatg ccaaggtagc 2580 cacagcacac ttatcttatc acgaacgtga cccacatcgg ggcgtacgtc aacacatgtg 2640 atgccggtat gataaccgtt accaagaaca cggtaatacc gatcccgatc aggttcacgg 2700 ttaccatctg gacagccaag atgatctgga agcgtatccg tcgacgtccc gggttttccg 2760 acacccggac aaacctccag gagtcataag cagggatttc ttccaactgg ccactctgat 2820 gagttaccgt gcgtgagcac ccgacccaac cgttgcggcc catgtttttt cgtggggttc 2880 tagtgggggt ctaggggtaa acttggtggt gacagcctaa tttgtcggcc acactctaag 2940 gtgagttggg tgcgtctagt gattgcccag tgcaccgtag actaccttgg ccggctcacc 3000 gctcacctgc cgtccgcgcg caggttgttg ctgtttaagg cagacggatc ggtcagtgtg 3060 cacgccgacg accgcgccta caaaccgttg aactggatga gtccgccatg ttggttgacc 3120 gaagacgtcg ctggcgcctc gccggcctgg gtggtcgaga acaaggctgg cgaacaactg 3180 cggatcaccg ttgaagaggt agagcacgat tcctgtcacg atttgggcgt ggaccccggg 3240 ctggtcaaag acggcgtcga agcccaccta caaactttgc tcgctgagca agtccaactg 3300 ctgggcgagg gatatacgtt ggtccgctgt gagtacatga ccgcgatcgg ccctgtcgac 3360 ctgttatgcc gcgatgagca gggtggttcg gtcgcggtgg aaatcaaacg gcgtggcgaa 3420 atcgacggcg ttgagcagct cacccgctat ctagcgttac ttaatcggaa cagtgttctc 3480 gcgccggtaa ggggggtgtt cgccgctcaa cacatcaagc cgcaggcgcg cactttggcc 3540 accgaccgtg gcatccgttg tgtaacattg gattacgaca agatgcgggg catggacagc 3600 gatgagtacc ggttgttcta aaatctcccg attagactga cgccatggct aggcaccgca 3660 catcgccgca tgggcagcag ccaatatcgc tattaccgtt tctattccgg gtggaaacag 3720 ggcttgacgg ttgtgagtgc gaaatgcgtc cgatcgttgc agcccgagcc ggaaaaccta 3780 tcgttattct ggatgtgatc acgaaatcca tgttgatact gcgcatttag tggcatggcc 3840 ggctgattca cggcaagccg gcatcgacga tcggcgacat tggtacaccc agtgttgggc 3900 tcaccgcgct acccgtggtc cgatccggaa tatagttttg agtgtctaag catcaggaag 3960 ccggctcgac caactcgatc agaacgccgc cagcatcttt cgggtggatg aagttgattc 4020 gcgcgttcga cgtaccctgc ctgggtgtat cgtagaccag ccggactccc tgtgcgcgga 4080 gtcgtttggt aaggcggtcg agatcgctga cccggcaagc cagctgctgg atgcctggtc 4140 cgtgtttatc caagaatttc gcgatcggcg atgactcgtt gatcggggcc atcaattgaa 4200 tctgggttgt gccgattggt gcgccgtgtg ccgatagcat ggcctcacgg atcccctggt 4260 cgtcgttaac ttcctcgtgg actaggatca tgcccaggtg gtcatgatac caggagatgg 4320 ccgcattcag gtcggctacc gcgatgccga cgtgatcgat cgttatcacc agagtggtgg 4380 ccagcagctg acaagtgttg atttgatcgg tcgtcatcac acaacggtag cctgacggga 4440 aagagcacgt ttctccagca ggttcgaatc ggcctgcaaa gaggacccga gagcagggct 4500 agggggtagt catgacgaca tcggtgatcg ttactggagc acggacaccc attggtaagt 4560 tgatggggtc tttgaaggac ttttcggcta gcgatttggg cgcgatcacc attgccgctg 4620 cgctgaagaa agccaatgta gcaccttcca ttgtgcagta cgtgattata ggccaggtgt 4680 tgaccgcggg ggccggtcag atgccggcgc ggcaggcggc agtagcggcc ggcatcggtt 4740 gggatgtgcc ggcgctgacg attaacaaga tgtgtctgtc tggtcttgac gccatcgcac 4800 tcgctgacca gctcattcgc gccggagaat tcgatgtggt ggtggctggc ggccaagagt 4860 ccatgacgaa ggcaccacat ctgctgatgg atagccggtc gggttacaag tacggtgacg 4920 ttaccattgt ggaccattta gcctatgacg gcctgcacga tgtgttcacc aatcagccga 4980 tgggcgcgct taccgaacag cgcaatgatg tcgaaaaatt cacgcgccaa gaacaggacg 5040 agtttgctgc ccggtcgcac caaaaggcgg cagcggcatg gaaggacggc gtcttcgccg 5100 acgaagtggt gccggtgagt attccgcaga gcaaaggtga ttcgctgcag ttcactgagg 5160 atgaggggat tcgcgccaac accagtgccg agtctttggc cggtctgaag ccggcgtttc 5220 gctgcggcgg cactattact ccaggctctg cgtcgcagat ctccgatggt gcagccactg 5280 tcgtggtgat gaacaaggaa aaggcgcagc agctggggtt gacttggctg gtcgagatcg 5340 gtgcccacgg cgttgtagcc ggcccagatt ctacgttgca atcccagccg gccaacgcaa 5400 tcaagaaggc ggttgaccgt gaaggtatct ccgtcgagca gctcgatgtc gtagagatta 5460 acgaggcgtt cgcggcggtg gcgctggcct cagcccgtga acttggtatc gcccccgagc 5520 ttgtcaacgt caacggcgga gcgatcgctg tcggtcaccc cctcgggatg tcgggagcca 5580 gaataacgtt gcatgtcgcg ctagaattgg cgcgtcgcgg ttcgggttat ggtgttgcgg 5640 ctctgtgcgg tgccggtggc cagggtgatg cgctgattct gcgggccgtt tagttctgac 5700 ctgcgacgcg tccggggtaa tatgatttac gtcacaaaaa tggtttgcgg cgcccgaatt 5760 caattttcga accggttttg cgactacgta agcatgggcg ccagtgagtg tatcggtacc 5820 cgatgcgacg tgacagactt gacaacgtga cgtctccgcg atcccccatc aggcctgcca 5880 tggccggtgc ggtcgacctt tccggtctga agcagcgagc tcggcagaaa gcttcaacaa 5940 gtgaccccgc cagtcgagca acattgggag cgcgtggcac cggtagctcc gaaaacacct 6000 cggtcattga gatcaccgag gccaatttcg aagatgaagt actggtccgg tcccacgaag 6060 taccgatcct ggtgctggta tggtcaccgc gcagtgatgc gtgtgtaaag ctgcttgaaa 6120 cactatccgg cttggcggtc gccgacagcg gcacctggtt gttggcgacg gtcaacgtcg 6180 acgcggtgcc cagggtggcg cagatctttg gtgttgatgc ggttccgacc gtggtcgcgc 6240 tggctgctgg gcagccgttg tccagctttc agggcatgca gtccgtcgat cagttacgcc 6300 gctggctgga ttcgttgcta tcggtgacag ccggtaaact gagaggccca actcgttctg 6360 aggattctgc agaaattgat cctgcgattg cccaagctcg ccagcaattg gaagccggtg 6420 acttcctcac tgcgaagcag tcatatcacg cgattttgga tgccgatccg gccagtgtcg 6480 aagctaaggc cgcgatccgg cagatcgact tccttacgcg cgcaactgcg caacatcccg 6540 acgcggttgc ggtagccgat gctgcgccgg gtgacattgc ggcggcgttc gcggctgctg 6600 acgtgcaaat cctcaaccaa gatgtgaccg cggcgttcga gcgcctgatt gttttggtgc 6660 gcagcacatc tggagatgag cgcagttcgg tacgtactcg gctgatcgag ctgtttgaac 6720 tcttcgatcc cgacgatccc aatgtcatcg tcggtcgacg caaccttgcc aacgcattgt 6780 actgagtcct tcttggctct tgcgctacta gggttttgcg ttattgaatt ctaactacga 6840 tgccgacatc agcggcagca ccaacaccgc cgattccggg cagccttgcc acgggtcatt 6900 ggtggcgttg acgccaccaa tattgccgac ctcggagccg ttgtaggcga tagtatcggt 6960 gttcaacact tcgcgccagc gtccggccga cggcaggacg agtcggtagc ctttgtgttt 7020 tgagccaggg aaattggaca cacaggccag taccgagctg tcgtgggcat atcgcaggaa 7080 actcagtaag ttgttgacgg actcgttggc gtcgatccag gaataaccct tggtgagggt 7140 gtcttgaatc cacacacagc cccgggtggc tgaggtagag gtcgttgagg tcgtccacga 7200 ggagcaagac tccctttgga gaaaccgttt ttgtcgaatg ggaaccaatc tagaccgcgc 7260 tgctccggac tattcggcgt gctggccgaa ttcttggccc atgaacaaca gttgcttgcc 7320 tgggtgtgcc cactggtagg cgagtaggtt gtgtagtccg gaggccttgg tgtggttgtt 7380 gcccgacgtc cgtctccgca gcgcaccctt gctgtgtacc atctcgtcgt ggctgagcgg 7440 cagcaagtaa ttctcgctga atgcgtacag catggagaac gttatttcgt tgtgttggta 7500 gctgcgatgc actgggtagc ggctgatgta gtcgagtgtg tcgtgtatcc aaccccatgt 7560 tctacttcat cgaaaagccc agtacgacaa tgttgataag tcgcttcacg ccgagtcacg 7620 gagtcgactc catcggcgat ggtgacaatg cctggcgcgg atttgtgtgc tgtggtgctc 7680 atctcctgca gaaactgtac cgcttccaaa ttctcctgcc cgctgtggat attcggggtc 7740 cagttgccct cgggacgtga gtagtccggg tacaacattg acgcgaccgc atccacccgc 7800 aatccttcga tgtgaagctc tttgagccag tacagtgcat tggccatcaa gaagttgcgc 7860 atataaaata tgtaagtgtc ccagtctagt tgctcatcgc gcataggatc gtcctgttca 7920 tagaagggtg tcctatcaaa ccgccccaga tcctatgcgt cctttggaaa gttttccggc 7980 acctaatcca cgctgacacc gatgccggat tgatgcagct cgtcgataag cgtacggaac 8040 gcgtcgggag tgccaaattg tgatgtcggc gcgtagtacg acgtgacttg gtattttcac 8100 gttccagtga acggattttc cgcaaccgga ggcatctcaa cgtgggtaaa tctttgcgcc 8160 acaacatagt ctggaagctt gcgggcgatc tgacggtaac tgagtccggg acgccacgag 8220 ccgagatgga cttcgtaggt gcctatagga tcaaacaccg ggttgcgctg agtacggtgt 8280 gccatccatt cgtcttcact ccaagtgaag ttattctacg tgatctgtga tgccgtctgc 8340 ggcggtgctt cggtaccgaa ggcgaacggg tcggccctat ccagtgatga cactgtcggc 8400 gcagttcacc cggaatctgt acagaccatc ggcggggaag ccggtccaga ataattccca 8460 tacttccgac gggcccagcg ctcgcatcgg ggcaccgttg tcattccagc tgttgaattc 8520 gccgatcaag ctgatgcctt tagcgttagg tgtccacatg gagaacgaca ccccgtccac 8580 cgcgctgtcg gccgtggtga acgagcgtcg atggacacca agaacttccc agagcagctc 8640 gtgtcggccc tcggcaaaca gatgaagacc aacttcgctc agggggaaaa agcggtaagc 8700 atcggcgaca gtgtgcacat tcggtgtctg ttcgggaccc gtatagctca cccgcaggcg 8760 atagtcgatg aggtcgacga acggtatcgc cacagagaac aagccgtatt cgaggttttg 8820 caacgggaac cggttgtgac ccaccaccgc tacgacgtca actgcgtgcg gtcgaaacgc 8880 tcggatgaca gtgtggtcac cgtattagtg agcgcccaag gtgctgtgcg gattgtggtg 8940 tgcgccggac agcaggcgtg tcacgtcggc tggctcggtt gccaagtggc tcccggagag 9000 ttggtcggtt cggctcatgc atttgttccc tcggatcttt tcacctcttg cttagcagcg 9060 tgattcctta ttcgtacttt aggagtggca tattaatgat gtgagcgact gcttgacttg 9120 gagatcgata agaatataat tcatcttctt ccactggtat tgctggccat ttatctcatc 9180 gagcacccaa aacctttcgt agggatccat actcaactta gccatatcta acctagccat 9240 gtctaaccac agcgtagctt actcgggacc aagtgctttg agtgtcacca cccaccaaca 9300 cgcagtctcc ggtagccgta tagaatttgc cgtatgccag caatgcttcg ttgtccacat 9360 gatggaaatg aatggtgagc aattgctgta gtgtgggatg gattttgcga attttttatc 9420 tacttaatga aattctccag cgattttcct tcgacaagct cgctagcata gttgagagag 9480 cgcaattctt atttctctga atccagctat tcttcgttac cctcccgcac cgggcgctgc 9540 tcgaacaact cgtaaccgga gtacacacct caagtcggac tcatggtcac cgccagcact 9600 acgcggatcg tgaacatgac tgggccatta tggtggagca ctgcatgcag gatgtcgcgg 9660 gtgttgacga acaggttcgg cctgaggtag tcggtgattt cgttgccgaa ttcgatgatt 9720 tcccacttgg ccgtactcca ggtgaagtag gtataagact gcgtgaagcc gagcttggcc 9780 agcctgtatt ggcgtgccgg agacgtaaaa gcttcggata agaagagcac gtcggggttg 9840 gtgattgtga ccttacagat cagccaggat cagaagtcgc gtgacttggt atgcggattg 9900 ttgactcgaa acagcttgac gccgtgattg atccactata acactacacg aaccacttcg 9960 tcatagaggc cgacaagatc gttctcgagg tttaagggag tagatgtcct ggtatttctt 10020 cggatgattt tccgcataag ctattgtgct ataaggtaat tcggtgaaac aataacgatg 10080 ttggcgtatc tatggatgat ctgacgaaca ttgtagcgcc agatccaggg gccatttcca 10140 ttcctagttt acttgccgcg gaaacaaagt cgtcgatagt ttccaggctt ggatgaatca 10200 catcacatgg ccatcctcat cgctacccat cgcccatgga gatccgacat ctgtcggtgc 10260 ggcggtggag taattgttgc gacccttgcg atgtatcttg tcgagcggat ggatcggcag 10320 caggtacacc acgttgaatc ccatgtcggc tatacgcgaa gtaccgcggc tggggtggcg 10380 aaggtgccgt gtaccgggtt accgtcggcg tcccagcagc cggtcgggcg cggaaacatt 10440 tcgtaccagg agccaaaacg ggccaacggt cgatccaccc agactctgaa ctgctcgccc 10500 cgggtaacca gatcttgcag cggataattc gtcaaaagtt catcgatttc gggcgccagt 10560 gccagcgtgg tgcgggtcac cggatctctg ggggcgtaac ctcgtcgagg ccgtcagcag 10620 caggccacgc agcgcgcgat acaccggttg cggcatgctc gaacagcgct gctccggcca 10680 aaagatcgtt ggacaattct gtcttcaccc tggtcggcat gcaacttgac aatcagcgca 10740 tgccgccagg tgtgcatcgg atcgccccag ctgcgttgac tcggaagttt cacaatccga 10800 cgcggtcggg gggtgaactg accgtgaaaa acgtagggtt cttgacacat cgtcatgtga 10860 atcagcagca actcgactcg tcggacctgg gtgtggctgc aggacgtgct ttgaggtcct 10920 ggaccacctt gattcggtga gttttcgtcg cgagcagaca gcgaacccga ggttgcggac 10980 aaccagtgtg gggcgggacg gcttcgtggc cttctctcca taccgtggcg ctgaccggga 11040 ccatttcgcc gactacggct ttagcagggt acatgccgca ggagatgatc ggtgcgacgt 11100 tatggatctt gacctgaccg ggccaccacc actccttctg cttcgcggct tgccacacac 11160 gagggtgacc cagtgtactt cgtggcggaa tgcccccatt agctacccga tattcatcct 11220 agttgctagt cacgctcctg cggatgaacg gttgctaagt agccatgcgt gcaccggaat 11280 ccctaagtaa taaatcctaa gtaaggtggt ggtggagtgt gaaagctctt tattatttta 11340 ccatttttac cgttcgtgcc cacctatcgg actgcctcgc cgcgctcgac tagctattga 11400 ccaacctgcg gtggtcgtag gacaagtcga cgcaagatat attccgcgac catcgtttcg 11460 acgttgtgtg ggcaatgacc cggtggcgct attgtgaagt ggtgagtccg tcacggctcg 11520 acgagatggc actcgacgag gggttcctgt gccgactcga tgagcgggct gccgacttga 11580 acgactataa ctaagctgtt cgcggtggta tcaatagcag caggctgatg tgatgatgcc 11640 caacgccata tacgtactcc tcgatggaga tcggagtcgc cgaggcgtta cccaaattac 11700 tcgggcagct tcggcattct ggctggcggt cacctgaagg ccgcctccga tctgggggtg 11760 cagctgattg cggtggttct ctcctactgc tcctggcact tccgacagtc gtggaccgag 11820 aacggctggc aacacgagac ctacccgtcg ctggatccgc aagggctccc gttttggcta 11880 ctcaccgctg gcaacggcga tcctgtgttg gttggagctg actttgcccg acgctgcgta 11940 gctgcggacc cggatctggg gtcgcgccgg tgggttgtgt tccgttgtgt ttgctggact 12000 ccgacgtccc tgagaacgag cacgatctgc gggacgttac tggacgactc tatggaggtg 12060 atcatgagca tcgcatcaag caacaagagg tcctggtcgg tatcggcggt gtgcgggtga 12120 tccgcgtgtg taccttcagt gcggggctgc ccgcgcccga ggattccacg ggaacgaggg 12180 ccacgccgga tccctcgtaa ccgaacacat ccgcgaattg gtccaccgat tcgggatggg 12240 atttcgacac cgtgctggct gtcgtgcagt ccagcacggt attcatcacg gacaccccgg 12300 tgcatgccga tattgaccgg ttcccggtag agtctggggt gctgctactt ctcggatgtg 12360 ctcgcactgt tgccggggtt cctgtggagc gaagcctcgc acttggcgcc gagggcaatc 12420 tgaccaaatt caacatggca cacatgggtc tgcggctggc gcaacgggcc aacggcatct 12480 tgctgctgca tggcctggtg aactgggtca tgttcagcca gttatggtgc ggatttgacc 12540 acgacgaggt tgccgatcgg ggcgattacc aatggcgtgc atgtgcgcac ttgggtggcg 12600 ccacagtggt tgcagctggg atgcgaacta gctgggtcgg attcgttcag tcagtgacct 12660 cggagtctgg ctgcgattgc aacaggttga ttcgggccat ttgtggtgga tccgctcgca 12720 actgattgat gacatccggg agcggcttga gttgctcccg gtgggaacgc ggtgcgttgg 12780 acgtcgaatt gggctggagc agggcggtgt ttgatccgac tgtgctgact attgtcttcg 12840 tgccgccgcg ttcccaagta taagtgcctt accttgatgt tgcgcgatcc ggatcggctg 12900 gaacggctgc tgctcgaaga caacaagtga tcgttgccga gaagtcgcac cccgctggtg 12960 acggtggcaa ggcattgaat ccaacaggtg gcgcggttta ctgaccgtcc gcaggtgtgc 13020 caccgtatcg ccttcctgcc cgattacaac atgtcgatag accgcaaatt gtaactgggg 13080 ctgtgatttt gattgaacaa tccgctgcga ccattgtagg tgtgcggcac ctcggggatg 13140 aagagtgctc tgaacgacgg attgaatctg tccatacgcg atggctggtt ggacgaatgg 13200 tgcgacggag agataccgtc tgccaacagc gtggcggacg aggctcgtcg aggcgatctg 13260 gaagttggcg tgctctacga cctcctagaa cacgcggtgg taccgaagtt ctatgaacgt 13320 gacgaacgcg gggttctgtc acgggggatc gaaatggtgc gacacactct gcagacgttt 13380 tgggccgaaa gtgtgggcat cccgtataga tgtgtgacta cgtcgaacac tgctacgtga 13440 ctgcggcgca gtagctgcgc aggacggttg caccgcccga gagcggcgag acggtgggtg 13500 aggtatggcc cgcaagctgg ttgtttactg tcagcgcgta gaagaagtat ggccgatgat 13560 tgacatcacc tacgtcgacg gcaccgtctt gcccgataac ccggtgcttg gatcgaagtt 13620 gactctgact gccaccgtgc agctggccgg cttggggccc gatgaggtga cggtgcaagc 13680 ggtgcttggt agggtgggag gcagtgatat ggtgatagat caggtcaata tcgaaatgac 13740 ctacatctat accgccgagg gcggcaacga gatcttttct acgacaacgc tgctgccttt 13800 gcgcggggtg ggcgtttcgg atacacggtg cgaatcttgc ctcgccatcc gatgtttgcg 13860 gccagtaacg agctgggtct ggccatccta cttctagtag atacggcccc cacctacctc 13920 atgactccct gcggatcctt ggcagccccg tgaggctgtt cctcgcttgt gtcaccgaac 13980 tgaagctttt gattgccggc gatcaatttg cttggcatcg acgaaacgag gagctcgttg 14040 ccctttgctt ttgccgcaat ccgtgccgcg aagagatcac attgtgacca gagaaattct 14100 tttgctcgcg gatcagttcg ccagcgtgca gtctgatccg gacatgcaac accccggcta 14160 ttgggacgat catgacgctc cgcgaagtcg tgccggagcg tgattgcata acggatcgtg 14220 ctgctggcgc tgtctaacgt tacgatgaat ccatcttcct gcggatttga cctcaaagct 14280 gcagtgcgtt gttagatgac tacggatgac agtgttgtgg ccgtgcagca gcttgagcca 14340 ccgctcgttc ccgagttact tggtgaacac cgtcggagcc ttcgatgttt gaagaacatg 14400 attgtgaccg ttctgtcggg cgccgctact gtgtgcaggt tgggacggtt tagctcgatg 14460 gattgcgcaa cgctgtccaa tctcgtccag ctgtgcatag gcttcagttc ttggggggct 14520 tgatgctcct ggcgcagttg catgagtggc tccacttcga cgccgtatgc caatgcgtag 14580 cgccagcgca ggctcctggt tgataagacc catcgccttc tgccgatcct ccctgttcag 14640 aagtgcgttc gtactcttac tcttagtaga cttgccgggt cactagatcg agtcgatctc 14700 ggccgttgcg cgccagcgga agcttcgaaa tggcgcatgg cattctcgtc gcggccggtc 14760 accgcggcgg cagcccattt gcgttgaagt tgaataagtg gatccttgcg gcacttatcg 14820 gtgtgccacg ctaggacttc gcggactgcg atccggccgg tctggcgggt gctgtctctg 14880 gtggaattgc aggaatccga ctacattgct atgcgtcacc atgtgatgcc ggcgcgggtt 14940 agcgtcgctg ccgatgccat cccgctgcga attgtcgtcg tgtgcatcag gtgtcgacga 15000 tgttcggcac ttgcggcgtg ctggaggcga gatcgtcggc gctggtacgg ccggcgatca 15060 ccgggatatc gtcgcccgcc aacgcggcta ccggcaggct gttttcgtac ggtacggtgt 15120 acgttttggg cagcaagtac tcgtagacat gggtgtctat cgcagtcgta actatgcctg 15180 tggcggcaag ggctacgatc atcgcgctaa tggtgatgtt ggccgaactg gtcaaccggc 15240 agcccagtcg cctctagctc ctccaacacc cccaagtggg tggatccgcg tgccacgcca 15300 cggtcgagaa ccagcccgat caagcgactc gcgatgcgcg cggcaagcgg gcgaaggttg 15360 gcggtggcgt tttcagggcg aaccacatgc atcgactgcc gcgtgatcac ttcctcccac 15420 ctgcggcggt gttcacgtta ggtgtgcggg tctgccaata cccaggtagg tgccatcccg 15480 cacgtgtcgg tagcggagtt aacggtggtg ctgggtcggc aaccaccaac acggcgcggt 15540 cagctatgtg caagcacaaa tcgcgtaagc ttgcgttgcc ggctgtagcc tgcagtacca 15600 ttttgtccgc agcaagctcc gcgtttccag ccctttgcgg tcgacgcggc cggggctcag 15660 cgcgtagctg ccgcgaccgc ggcgtatttg tgggtatgtc gcgatcccat ttcgatcagc 15720 gggcgttccc cagcggtact gaccatggta agtagccgca gatgcgatcg cactgttgtg 15780 gttgaagatc gatagcatca gcgtttcgat caccacgcat tcggcgcagg ttccgagcac 15840 cgataggtac aggtgacccg ggaaagttag agttcacctt ttgcgtaccc gtcgatgtcg 15900 ccgccgaacc ggaaaccgtg tagatagttc aacgtgtcgg ggccgaggaa ttgggccagc 15960 aactggcagg gatcgttgaa cctcaactgg ggcaaggttt ttagcaatcg accgattacg 16020 gcaatcaccc tgtaacggcg actatccggg agtcggcagg tgaacacttc caatgtggtt 16080 cagcggtgag tggtgccgtt gtgtaatgtc acttgtcaac atagttaatt tgtacctgtc 16140 ggtcagcagc tcgtcgaaga ccgagttgtt cattccgcaa cggtaacggc tgtcagcgca 16200 agctcggtat cgtgtgggtc atggttgtta cgttagctcc gatagaaccg aaggtgaggc 16260 cgaacacaac ctggcaacac gagtcagctc cagtagacat cacggccgct cgatgggtca 16320 cgattgtgtg ggatgacccc gtcaacttga tggcgtacgt gacgtatgtg tttcagaaat 16380 tgtttggcta cagcgagcct catgccacca agctgatgct gcaggttcac aatgaaggta 16440 aggcagtggt gtcgatgggt agtcgggagt ccatggaggt cgatgtgtcc aagctgcatg 16500 ccgccggttt gtgggcgacg atgcagcagg accggtgagg tccgaaggta tccaggatcg 16560 ttcgtgcgca aatggaagcg cgttgagact gccaacggcc cccgttttcg gtccgtcgtg 16620 gcgccgcacg aggttgccct gctcaagcac ctcgtcggcg cgctgctcgg cttgctgaac 16680 gagcgtgaat cttcctcgcc tctagacgaa cttgaggtaa taaccggtat taaagccggg 16740 aatgcgcagc gcccggagga cccgacgttg cgtcggctgt tgccagattt ctacactccg 16800 gacgacaagg accaattaga ccccgcggct ctcgatgccg tcgatagcct gaacgccgcg 16860 ttgcgcagtc tgcacgaacc ggagattgtg gacgccaaac gctctgctgc acagcagttg 16920 ttggatacgc ttccggaaag tgacggccgg ctggaattga ctgaagcaag tgcgaatgcc 16980 tggatcgctg cggttaacga tcttcgactg gcactgggtg tcatactcga gatcgaccgg 17040 ccggcacccg aacgggtgcc ggccggtcat ccactatccg tgcacttcga cgtctaccag 17100 tggctgacgg tgttgcagga atacttggtt ttggcgctga tggctacctg atgatcttga 17160 tggcagcgcc gatgaactcc ataaccgaca tttcgggtat ccaggttggc cactaccaca 17220 ggcttgatcc tgatgcgtcc cttggtgcgg gttgggcgtg tggtgtgact gttgtgctga 17280 caccgcctgg gacggttggc gcggtcgatt gccggggtgg ggtgccaggc acccgggaga 17340 ccgatttgct tgatccagcc aacagtgtgc ggttcgttga tgcggtgttg ctcgccggcg 17400 gtagcgccta cggtctggca gccgccgatg gcgtcatgcg ctggctggag gaacacgagc 17460 gcggcgtggt gatgctcggc ggagtggtgc ccatcgtgcc gggtgcggtg attttcgatt 17520 tgtcagtcgg tgactttcat tgccgaccga cagcggaatt cggctatttg gcttgtcaag 17580 ccgcttacga tgccgctgtt ggtggtcaag atgccaccgt ggctgtcggg acggtgggtg 17640 ccggggtggg ggcccgcgct ggcgtgctta agggtggtgt cggcaccgcg tcgatcacac 17700 tggagtcggg gccgacggtg ggcgcggtgg tcgtggtgaa ctccgtgggc gatgtcgtcg 17760 accgcgccac tggtctgccc tggatgacag atctgatcga cgagttcgct ctgcgaccac 17820 cctcgcccga gcagatcgcc gggtttgcac agctaaagtc cccgttgagc gcgctgaaca 17880 cgacgatcgg cgtggtagcg accgatgcca cgctgagccc ggcggcgtgc cagcgtgtcg 17940 caatggccgc tcaggacggc ctggcccgaa ctatccgtcc agcgcacact gcgctggacg 18000 gtgacacggt gttcgcactg gccaccggag cggtcgaagc cacagcgacg gctgatgtac 18060 ccgtcgcgat gtcgccggag acgggcctga tcactgaggt cggtgcggct gcggacgact 18120 gtttggctcg tgcagtgctg gttgcggtgc tggctgccga gtcggtcgct ggaataccga 18180 cttactgcgg catgtttcct ggagcgttcg ggaccacaat cggagggggc aaccgttgac 18240 gtggtggtga ttcgtgctga ctggtggagg cgatagtgtc ccacgcacgt cgcgaccacc 18300 ctgacgaagc gtgtggggtg ctggtcggtc tcgagggttt cgatcgcccc caagcgccac 18360 atctcaatgg tcaacgctga gcggtcgtcg acgttctact gattcgatgc gcaaaagcag 18420 ctccacgtgt ggcggtcgat agaggacaca ggtaaggctg ccgtcgtcat ctatacactc 18480 acatatcgag atctagcggg tatgccagcc gtacgaatgt caacctagcc gctggccggg 18540 acgtaaattg tgtagttttt aattgtctac ccgcgaccca gacagtcacg agctgcctag 18600 gttctagtac cgccgtcgtc atcgagggat ccatcattat aacgtacgaa cagtactgaa 18660 taccccccga aaaggttctc cacgattccg agaaaggctc acatgagcgt cactggagtt 18720 ttacactcta accccgatta gcctgcgacc ccacatcggt gtccagaagc gcgtatctgc 18780 cagcggcgac acactagggt ggtcattatt tagtggccta gagtacaact actcgagtat 18840 cgccaagctc ctggttgata acgggaagtt acagctgctt cgtgaacatc tatgtcaacg 18900 acgaggacgt gcggttttcc ggcaacttac gcactgcgtt agtctacggg tgattcggtc 18960 accatcttgc ttgctgtggc aggtgggtga gctggagtat acgaagcgta tatgactcgt 19020 tgttgcaggc cctgggcaat acaccagtgg ttggtttgct acggctgtcg tcacgagtcc 19080 tgtggggcgc acgagccgca tgtgctgctg tgggcgaagc ttaagccgca accttactgg 19140 gttgactaaa ctaaaactaa ggagtggctg gcgttgcgga tgatctagca ggccgaagac 19200 gacaggctgc tggcgccggg tgcgactaga ctcaagccta cttaatcatg gtagcattgg 19260 tatataactg gcgatggcag ctcggctcaa gagttataag ctgatgggtg tgaggcccga 19320 aaacacgtcg gtcgagcgcc atcggctgtt agagttctat ggtgagcaga tagttttctc 19380 gccaacaaag ggcggatcca acattgcggt agccgccgcc aaagaggctg gccgttgcta 19440 atccattgtg gggaggctgt gtcagtacgg caattcggcc aacatcgact accactaccg 19500 tagcaactac ccgagttgct tgctgacctg cccgaaataa cccattacgt cgccggccta 19560 ggcgccacgg gtacagtgat ggttactagt ggatttctgc gtgagcatgt ttctggcgtc 19620 aagatcgtgg ccgccgaacc ccgctacaac gagacaacga gggggtatat gcgctgcgga 19680 acattgatga aggatttgtt cccgagctat acgacccgga cgtgctgacc atccgatact 19740 cggtgggcgc ctccgacgct gtgtgtcgta cccgaaacta gtggattccg aaggcatctt 19800 tgctggcctc tcaactcaac cggtgcggtg ctgcatgtcg ctttcgcgat ggaatccgtg 19860 gtgctagcgg ctggtgaacg cgctgacgtc gcgttggtgg ttgccgatgt cggctggaaa 19920 tatcggtcca ccgggcggcc ctaccccggt agcctggcga tgaggctgag gacgccctgg 19980 acgggcagtt atgggcatga cccgtgccgg ccgacgatgc agagcgaagc gatgataatg 20040 gagtgacgct caatgacccc aaccggcgac tggtataaag gaggtgatga ggtgggggca 20100 ccatccgctt gcgggggagg atcggcgctc atgaccctgc cggagaaaaa cctgggctat 20160 aaaccggaga ccgagacaaa caggcgtctg cggtggatgg tgggtggggt cacgatcctc 20220 acctttatgg cgttgcttta cctcgtcgag ttgattgatc aactgacgcg gcattccctg 20280 gataacaatg ggattaggct gttgaaaact gacgtcctgt gggggatcag cttcgcgcct 20340 gtgctgcatg ccaactggca acatctcgtg gccaatacga tcccgctcct ggtactgggg 20400 tttctgatag cactagccgg attgtcccgg ttcatttggg tcaccgcgat ggtatggatc 20460 tttggcggct ctgccacctg gcttatcggc aatatgggca gcagcttcgg cccgaccgac 20520 cacatcggtg tctccggtct gatcttcggc tggctggctt tcttgctggt gttcgggctg 20580 ttcgtccgca gggggtggga catcatcggg tgcatggtct tattcgcata cggcggtgtg 20640 ctgttgggcg tcatgccggt gctcggcaga tgcggtggtg tgtcgtggca gggtcatttg 20700 tgtggcgcga tctcaggtgt cgtggccgca tatctgttgt ccgcgccgga acgtaagacc 20760 cgcgcgctca aagaagccgg caccgattcg ccgcgtctga agacatgagc tcgccgctgt 20820 tgcccgttgg ggtctttgac tccggcgtcg gcggcttgac agtcgcgcgg gcgatcatcg 20880 accagctgcc tgacgaggat attgtgtatg tgggtgacac cggcaacggc ccgtacggac 20940 cgctctctat ccctgagatt cgtgcgcacg cgttggctat ctgtgacgac ctagtaggcc 21000 gcggcgtaaa gatactggtg attgcatgca acacggcgtc tgcagcgtgc ctgcgagacg 21060 ctcgtgagcg ctacgatgtg cccgtagtcg aggtcatttt gccggcagtg cgccgcgcgg 21120 ttgccgccac ccgcaacggc cgcattgggg tcatcggcac ccgggccacc atagcctcgc 21180 acgcgtacca agatgcgttt gctgctgccc gcgacaccga gatcaccgcg gtggcgtgcc 21240 cacgctttgt cgacttcgtc gagtgcggtg tgaccagcgg tcgtcaggtg ctcggactgg 21300 ctgaagggta tctggagccg ctgcagcgtt ccggggttga cacgctggtg ttgggttgca 21360 cacactaccc actgctggct ggactgattc aactggcgat gggagaaaac gtcacgctgg 21420 tctccagcgc cgaggagacc gccaaggaag tgctgcgggt gcttaccgaa agagacctgt 21480 tgcgtcgaca tgacgcgccg cccgttaacc gggttttcga agctaccggt gaccccgaag 21540 cgttcattca gttggctgcg cgatttctcg gtccagcggt gagtggtgtt caacctgcgc 21600 gacttcattc tcgtgtccgt tagatgagtg caagagattc tgatcacctt aatgggcaat 21660 gttttcctca tcctggtatc gggcatggca cagtagtgac cgtgcgcata accgtgctcg 21720 gctgctccgg cagtgtcgtg gggccggatt cgcctgcgtc gggttatctg ctacgagccc 21780 cggacacccc gccgctggtt cttgacttcg gtgggggagt gctcggtgcg ctgcagcgac 21840 acgcggatcc tggctcggtg catgtgctgt tgtcacatct gcacgctgac cactgcttgg 21900 acatgcccgg actgttcgtg tggcgtcgct atcatccgac acgcccggtg ggcaaggcgc 21960 tgctatatgg cccggacgat acctggttgc ggttgggggc ggcgtcgtca ccgtacggcg 22020 gcgagatcga cgattgctct gatatcttcg atgttcgcca ttgggtcgac ggtgaaccgg 22080 tgcccctggg agcgctgatg ataatgccgc ggctggtggc tcatccaacg gaatcctacg 22140 gcttgcgtat caccgatccc agcggtgcgt cgttggtcta cagcggtgac actggtagct 22200 gcgaccaact tgtcgaactg gctcggggtg cggatgtctt cctctgcgaa gcatcctgga 22260 cacactcgcc ggacagaccg ccgaatctgc atctgtcggg caccgaggct ggcagggcgg 22320 cggcacaagc aagtgtccgt gagctgttgc taacgcatat cccgccttgg acgtcacgtg 22380 aggacgttat tagtgaggcc aaagcggaat tcgatggtcc ggtgcacgcg gtggtgtccg 22440 gtgagacctt cgatatccaa gctcccgaac gagtctgagc tggcttacgg cttgtcgcag 22500 gttgcttgcc tgcttcttgc gcggacgccg tgaaggcgcg ccaccctcgg cgggctaggg 22560 ttgctgcgtg tccacacgag cagacggtcg tcttgatgac gaacttcgcg cggtggtcat 22620 cactcgcggg ttcaccgaac atccggcggg ttcggtgctt atcgaattcg gtcacacaaa 22680 agtcatgtgc accgctagtc ccaccgaggg agtgccgcgc tggcggaagg gatcgggtaa 22740 ggggtggctc accgccgagt acgcgatgct gccgtcggcc acccatactc gttcggaacg 22800 cgaatcggtg aaaggtcggc tcagcgggcg cacacaggag atcagccggc tgatcgggcg 22860 gtcattgcgg gcgtgcatcg atctggcggc gctcggggag aacaccatcg ccgtcgactg 22920 cgacgtgttg caagccgacg gtggtactcg cactgcggct gtcaccggcg cctacgtggc 22980 gttggccgac gcggtgactt acctgtcggc tgcaggcagg ttattagatc ccaggccgtt 23040 atcgtgtgcc atcgctgcgg tcagcgttgg cgtggtcgac ggcaggattc gggtagacct 23100 gtcctacgag gaagactcgc gggccgaggt cgacatgaac gtcatcgcga ccgacaccgg 23160 gacgctggtg gagattcagg ggactggtga gggcgccacg ttcccgcgtt cgacgctgga 23220 caagcttctt gatatggcac tgggtgcttg cgacaagtta ttcgttgcac agcgcgatgc 23280 gttggcgctg ccgtatcagg gtatgtcccc tgagggaccg ccaccgccga aggcgttcgg 23340 cagctgagtg tgccggcgac gatgcagagc ggagtgatga tgtgggggta tctcccagcc 23400 gtgaagcggc gagaggggtg gcgcttgtga ccaagctatt ggtcgctagc cgtaactgga 23460 agaagctggc agaattgcgc cgtgtgctcg acaatgccgg gttgtcgggg ttgacgctgg 23520 tatcgctgaa cgacgtggtg ccgttcgatg aggccccgga agccggcgcc actttcgagg 23580 acaacgcgtt ggccaaggca cgcgatgcgt ttgcagccac gggtttggcg agtgtggccg 23640 acgactcggg tttggaggcg gctgcgctgg gtggcatgcc aggggtgctg tcagcgcgtt 23700 ggtcgggtag ttacggcgac gacgccggca acaccgcgct attgctggct caattgtgtg 23760 atgtgcctga cgagcggcgc agcgcggcat tcgtgtcggc ctgtgcgctg gtctcggagt 23820 ccgacgaagt cgtcgtccga ggggtgtggc cgggcacgat tgccagggag ccgcgcggtt 23880 acggtgggtt tggctatgat tcgatcttca ttcctgacgg tcctggcctg ggaggccgca 23940 cagtggctca attaaggccg gcggaaaagg atgcgttctc gcatcgcttc cgtgcgttaa 24000 cgttgctgat gcctgcgctg cgtgttcttg ccatgcgaac gtgaagctgg ccgcgatgcg 24060 agaacgagtg tgcggccagg cgcttcacgt tcgactgtgt ctaagcccga agcgcgtctt 24120 gacgtctttg gtttggaagt gctcgacgat gatgcccagc agcgggacgg tgccggccag 24180 cagcacaccg accgttttgc cgatcggcca tctgaccttg atggcgaggt tgaacgcggt 24240 caacacgtag acgaaataca cccagccgtg caccacttcg atccaccgga tttcgtggtg 24300 gaagacgagg tgcgagacga tctcgtagca cagtgcgatg agccagatcc ccgttgtcca 24360 cgccatgatt cggtagccga gtagcgcggt gcggctcttc tcaaaatcaa agtcgggtgc 24420 ttggggtgtc tcgggtctgg tcatgtggtg gtcctgttat ggttttcggc gtcttgcttt 24480 gccagctcgg ccaggtaggt gttgtacttc cggagggcgg ggtcatcggg tggctgctgc 24540 tcgggcttgg ggcgagcggg cagcagttcg ggtggaattt cggctatgca gttcatgtgc 24600 cgtggctgtg ggggtgactc ttcgtagcgc acgaagttgt ggtatgtgta aaggcagaat 24660 ccggcgaaca gcggccactg taaagcgtag cccagattct ggaaagttcc cgaggctgac 24720 tgaaacctgg tccactgcca ccagcccagg gccaggcagc cacaggccgc aatggtcacc 24780 aaagcaacta gtgcgggcct ccgacgacgt gtagtggaca ccccttgacg gtacgctcac 24840 gatttggacc cggtgaattg atcgcggcgc gccactgcgg tcttgcggta gatggcgacg 24900 gcatacttgt ccggccgagt ccaccgtatt cttaaggtta tcgagtgctg cgcagagcag 24960 tccactgata tcgtaggatt ggtttgatga tgtggtattg cctgcgtcgg acaccatgat 25020 tattggcgat aacacggtac cggttgctat cgatttaagt cgcgaatgag ttcttccgtt 25080 gcttgtgtgg cgattagttc ttgccagagc tccaaaccga atcgatctca aatagtttct 25140 tgccgggact atgctgaggc agcaaacagg gtcactagtt ttaatagagt gaaacctcga 25200 tgcaatcgtc ggaacgacgt agcatcttcg ttcgctgtcc cggtgtcagg aggtcgatcg 25260 cctggcagca gcggtcgatg atcccgggta ttttcgtcaa gagcgatcct gagccgctag 25320 acacggccgc tccatgaggt gcagtcatag ctgaaattag gtgccgagga gataacaata 25380 cgtcgttaat tgggagggcg ttgaagtata tggtcaatac cgcatggtga cgatgcgctc 25440 gggcgcgttg gtcgaattgg tctgggatcc caccagatcc aaacagtctt tcggagtatg 25500 ttggtccgtc gggctatcgc gcagtcgttg aagccgttgg cgacgggtag cggaacggct 25560 tcgaattatt gtgccgatcg catctgtgtg ttccttgcac cgaccataat gaacccaagg 25620 tgggagggct gtctacgggt tcgtcggtga gcggaccggt accattggca ggctcgcggg 25680 cgtgatggaa tggcagacat gccggcttta ggtgccggtg cttgaaagag cgtgagggtt 25740 cgactccctc cgcccgcact cttcagctga acaggccgcg gtgttgttcc acgtagagct 25800 gcactgtctg tgcgggatgg ccggtggtgt cttcaacatc gtaggttgag cggcgatagc 25860 ggtcttcgcg gtgcagtttg gccgtggtgg cgatgtgttg tcgcacatgc tggggccggc 25920 taatttatag cttatcaaga agcgctagcc gctcgttgtc ggacggctaa acggtgctga 25980 tgggtcggcc cagggcttgt gtgtgttgct ttgccagctc atcgatgtcc agcgtcgtca 26040 gccagtcaat tcatagacca cgcccagatg attcgtgggg tgtgcaccgc ggtgacgatg 26100 tcgctggatg cgacgggcga ggtgcggttg gctccgaacg gtaggggcag ttggtcgctt 26160 tcccggactg agcgcgcggc cactagggcg aagaacgggt tcttgagcaa gatagtcggc 26220 ctgatgtgta tgtgtgggga attttagcag ctgacgaggt gttaagcgaa gacgattcct 26280 cgaatccgtc cagaactttg gtcgtggtgt ccctgatgag accgtagtct tcgatgtaag 26340 tcggcggtgc gcacaaccgc gtcctgggca aggatttgct ggaactcctc gccagagatt 26400 gattctgagg acttctgcgg tggttattgg ctaacgctcc tcgctgatgt cggcccggct 26460 cgaatcttcg gctctaccga aaccttacct ggtatttgtc gagcgccctg aaaagcaata 26520 gtggttaggg atgtgggata caggtggcgt tgctaagtga ttggatcacg gtggtcacag 26580 gcggtgcaca agatctgggt ctggccattg tcgagtggcg cgttgtggag ggcgcgggtg 26640 gtgctcggtg ggaggacctt gagacaacct ggagttgcga cgaaacaatt gggtggtgca 26700 gatgttgcct tagcggtgtt gtgcaagtag caagtaattc gtgcagccga cgtcgacgtc 26760 ctatcctcgt gcggacggcc gtcgaatagt ttcggtggag gtggacatca tggctaacgc 26820 cgtcgggatc acccgcgtta cggtggtgcg caagatgact gaagagcaag tcgacgcggt 26880 cattgttggt gcatctgacg ggggacttga aacggtgcca ggatggtggc agcgatcatg 26940 cgggggtaac aacgtggcgt aattgtgacc atcttgtagg tgtctggcat ggccggtcag 27000 accaattatt cggcggttaa ggctgggaat ggtgatgacc aaggctgggg ttaaagagct 27060 tgcttaagct aggtgttcgg gtgaacgcga tcgctcctgg gatgatccgc tcggtcatga 27120 ccgaagcaat gccgcaatgt atttgggccg ctaaagtggc ggaggttaca gtgaggtgag 27180 ctggggagcc tagcaaagtg gccaatgccg ctctagtgtt tttattttcg atctgtcatt 27240 gcatatgccc ggaactgtta tgggaagtca ctggcgttct acacatctga aaccaggaga 27300 gtggctatgc gccaagttgt tatttattga aacctagcaa gtatttgcgg tgatgcgaca 27360 gtggagtttc gttgccgtcg aacgggaacg aactaatatg cacggttagg aaatctcact 27420 aggtcacccc gtgggtgtta ccggtggcag ggtgttaatc accttgatgc gctaactcga 27480 ttgtcgtcag gaatgttatg ggttggaggc tatgtgcaat cggcagcgtc gcgatcttcg 27540 aatggtttgc gtcaacatga atggccctgg gttgccgctg atcggtgtca gcgttgttag 27600 ggtgtcaatt tttgtcttcg cacctttgtg tgctgcaatg ttcagccagc ttggcgcggt 27660 gatccgtgtg aatctgatca gcgatgcctc cgacgtacat cgctggccga tggcgacaga 27720 cggtacgtcg atttactgtc ctgatcaaga gaaagcgttc ggacacgatc gatctgcttt 27780 cgaccgaagg gtaacagctc gtccagctgc tggtcgtcga gggggacgac atcgtcgtca 27840 ccaacgtcgt tagcttggcc agggtaggcc atgattgctt ggctgccaag cgttccgatg 27900 tcgttgatgt ttcaccttgc ttgggtgcgt ctgcggtgcc accggtgtgg attacaccgt 27960 gaacgcgaat gtcggattcc cgctcgtcac cggcccggcc aatcatgact gggcctatcc 28020 agccatgtgt taccggtctg ggatgtgtgt tgtggcatct acgctgtgct ggccgtcgtg 28080 gtcgctgtcc gctgccgtga ccaatctggg gtaggtgtac acatcagtct ggcactggag 28140 gatgtcgcgc tggccactgc tagacacttc gggttattga cactgagtac gcaacgccca 28200 cgtttcgaca acgccatcta cggccattac ggtcatgatt gcatatgatt gtattcagtc 28260 gtgatgggac agcgttcata attgccgggt tgaccgggag gagctttcgc gacttggttt 28320 aggtaatcgg aataggggta gcagtggctg cgcttgccac ggtgctccgt gttgactttg 28380 acgaccaagg cgtccggagt atcggtatct tgaagtgttc tccggcttgc ttgcgaccta 28440 gtcgagccaa ttacacagac gaagatatca cacaccgtgt tgttggaacc actgttctgt 28500 ttgagcgata ccgcacgttc gcagaggttg ccgatgacga gcgggtaatt tgcaatctgt 28560 tgttccccgg ttacacagcc tggtgtcgga gagtgtttcg ccctcgggat gtcggtcgcg 28620 ttcgacggta ctcatcccgc tagcacgctc gccccggata gatgtcctca ccaactgttt 28680 gagcttgacc aacgccgaca tcacgcgctt tttaagtgct agaacgatcg ttggctgggt 28740 tgcggtaagg aaattcgtcg acaaggacaa ggaagtcatt ctcaacgcgc cgtaacgaaa 28800 tgcggtgacg cctatgcgca ggacatcatc gatcggatac gggatatggg tcctgttcgg 28860 attgatgatt acgcagactt acggcgtcct gggggagtcg ttattgacct actcgtttac 28920 gcgttgggcg ttgaggagct ggcgcgcggc aggatgagtg tctctaaggt gcttaaactc 28980 acttaattgt ggcttacctg ttgtgccagc acggcacccg aggctcagaa gcagcttttc 29040 ctgcagcgtg catcacggac cggcgagtac agaggtgcgt tttcaatgtc agagccggag 29100 tcgggttctg atcttgccgc gatccgaatc cgcatggggc gtaacctgga cggcacccta 29160 caccattcaa cggccagaag atgtggccga ctaacggcgc taatttcacg ttggttgccg 29220 tattggtgtg caccgacgaa ggccgccgag aagctgcacc gcaacctcgc tgcgtttctc 29280 gtagaaaagc caaacgtttt cggtgaagtg gtgtctgggc taactatctc cggcaagatc 29340 gacaagctga gcttataagg gcatcgacac cacggaactc atcttcgatg gctacctagc 29400 aagcgttgat gacatccgtg gcggccccac tccggggcgg ggcttcttcc agatgatggc 29460 cagtatcgaa gtcagccgcg tgaacgtgtc ggcaagaact tgtggcgtcg gcattcgtgc 29520 cttcgcgctc gcggtgcacg acttgtaatt aatagtagtt tagtagcgtc acaccttcgg 29580 taagccaatc gcagagcacc agaccatcgt gttactgctc accgaaatgg tgatcaaagt 29640 caaagccatg catctgatgc tggtcaacgt ggtacagttg aaagattcgg gttgagcaac 29700 gacttagctt ccggtatggc taaatacctt gctaacgaat tctgttccgc agtctaccta 29760 gcagagcgtc cggattcacg gcggttactc ttacttcaag gactacgaga ccgagtggtt 29820 gatgcgctcg acgctccgtt cttgctcatc ggtgaaggaa gcagcgaaat ccagaagtcc 29880 atcatcagca agcggattat cggagtgaat tgtgtgtgac cggtgcctgt tcttgactca 29940 ggtgcgcgac ctcaactgtc cgaggacgtt gcgcgctttg tccgcaagag gatcttcgat 30000 ggtacttacg tagcaggaca gtagaccaat ggaccacgga ttaggggata aacgtcacac 30060 tggttgtgaa gcgctgttta ttctaagtgc gcaaggtttg cttgcccagc aacggcgccg 30120 cggctaacat caccgacagc caactgctgg aactcaaaaa tatccaggac cagctggaag 30180 atgcttatgt cgaaaccggc gacgagcgaa cggttcctct caattttcat cggggcatca 30240 atgttgcgat ggactcgcta aaatttgctc agctgatgtc gcagattacc cgctacgcgc 30300 ctgaattcgg tgttccccat gatcggggac tgtcctgacc agtctgaact ggtaccatca 30360 cccggttttg tctgcgctaa agaaacacga cggcaagatc gcccgggcta caatgtcgga 30420 aaccttgccg ccgctgctat tccgtccatt gaccaccttg ttgcgcgtgg tgtgcttgct 30480 gaagtgagct gttcgtcatc tcggcagcgt cggcgcaata cggttgagtt gaggttttta 30540 cggaattcgc taagaattgc tacatgctgg gggtttctat agcgacgctg caggccattt 30600 agtatccgtt agcggatata gcaatcaccg tccaaagcgg ctgtaatttg gcccggcgcg 30660 cagcttggtt cttggataac gaacccgacg aataaccaga gtttggccgt tgtcggtgtt 30720 cgcgttcatg gctgaggagg tcgttagggc ggcgacgatg tcgcggttaa tatccaaggc 30780 agcttgggag ttttggcgta agccgccgcc acggcctacc tgacctagtg tacgccgggg 30840 gtagccgttg gcgggcagtg atccaggttt cagcgcccag cagactgccg agattgtggc 30900 tgcccgtgag agcgcgttac ttaaccgtac tggtttccgt tacttaaccg tactggtttc 30960 aaggaaggag cttcgctatg gatttctttc ggattcagct gtccgactaa gaccgccttt 31020 cacgacgaag cgtggaagtg tatcgtcgca cacatgaccg aagaagtcag gcgtcgagac 31080 cgctagacgg aagacaactt taattaaagg tctgaatctg acgttcggca ctgcgggggt 31140 atcttggctg cggggtggaa gccagcatcg tacggcggat tcagcgggat gcggcggcgt 31200 tagatatagt gcgcgggcac acatgtcgtg ggtggcctgg gaactaccgc tatggtggcg 31260 ctgtttggtg gtgaagtagt tccgttcggt ttcggttgag cttcatgccg aggtgttacc 31320 tggggtgtcg gcggccaagt acggatgtgc ctctgctata ctgagcccga aggcggttcg 31380 gatgttgcca tttgcaaaac ctgagcagta cgtgatgttg gtagctggct gattaactgg 31440 tcgaagatgt tggctaccat actgttgcgc acaactgcta ctgatgctct catcagcgtt 31500 cttggtcacc aacacctcat ccggatgaaa tatgacacta gagcttgatc atgtttctgg 31560 tgccgcagca ctacttgccg gccatcaaaa tccagggcat ccgtgccagg gcatccgtgc 31620 tatcgacggt gaccggacca acatcgtcta ctacagcgac atctgcgccg acgacagata 31680 tcgcctcggc caggcgtaag tgggctggac ggtggtatgt gagccaacac caagcctggc 31740 gtcctgcaag tcgtggccgc acccgacggc ttgcaggaca cctcaatcat gaggcatcag 31800 gtcaagttgg tagccgcagt ggtcgacaac gccacttaag cacctgtgcc gattcgctac 31860 tcaactagtt tgagcgagcg gctcttaggt agttttacgt taggaccaag cggaactgac 31920 agagcggtca gtgtcagcca tggaggagct ggcgcgttgc accttttggc cgtgagagtt 31980 ggcctgctcg taaatcatct ggaagttacg acccaggtcg gctatgaaca tttcatgggc 32040 agtcgaacct tgtccgcccc aaaactcagc ggcgtcccgc acagtggcta gaatggcctg 32100 gtgggtggtc tccaacgcag ccgcttgagc gcggatagcc gctccatgtg cgtcgatctc 32160 cccaaactgg tagttaatgt ttcccattac tttgtctcct cctgcactga aagtattgat 32220 tagcagcgat tttcgcaact agctgccaga aaggattttc ctcgagttct cttcttggtg 32280 ctcgtagcga tcggcggcgg tacccagctg gtcacgcacg tcctgcagca gggtcactat 32340 gtggcgaaac gcctgattta tctgccccat ggtgtcgtgg gaggtcaact gggcggtccc 32400 actccagccc gcaccagcga tgtccatcga ggacatgaac atcttgtggg actcgtctcg 32460 cacgttctgg gcgtgcatgt caaatttgcg cgccatgtcc cgcatcgcct gtgggtcggt 32520 cataaaatgt gcagctgtca tcctttataa tttccttcca ttgatttcgt tgcgttgtgg 32580 atgaaacgtc aacctcgcag cttttatccc gctgcggggt tgcggggcat cacgaaagct 32640 cttggttgca ggcgtagtgc agtgttgacg ccgccagtac cgctgcctcc gccagggacc 32700 ataggtgcca tcggtagccc gccccccagc agcggcgccg attcgctttc ggttgcgacg 32760 gccaccctgg ctggcgacaa tgcgcgcgtc gctgccgtaa ccggctggct ggccgtggtc 32820 caagtttgcg gcacccgcaa cgagccgatc gacgcggccc gacccaattg agcagtcacg 32880 tgaccacccg agcttgaacc cagcaatccg cggcctgtcg actgtacagc acttcccatc 32940 gccttaaacg cgctttctgc tgccttggtc gtcgtcggcg ccaagctctt catcgccgaa 33000 cccatgccgt tgaccaatga caaacccgca ttggccatgc ccgcatggtt gttgatcatc 33060 gataaggtgt cgtttatggg cgacaagtgt tgtgcaaagc ccccccacaa ctgtggtgcg 33120 gcagccgacg aagagtcagg aacagctgtt tgtggggtgg cgacgtctac atttacttgc 33180 tggtccactt gcggtacgac agtagcttcc atcccctcat tgaccgcctg atcgagtgcg 33240 gcttggctga ttgcctgctc ggcctcaaca acctcctcaa caacctcctc aacaacctcc 33300 tcaacaacct cctcaacaac ctcctgggct aacccgacct cattgacccc cagcggcggc 33360 gccgtaaatg ctttcgtcgc ccccactgcc tccagcacac tagcttgata gctggtcatt 33420 gctgccgcgt cttggatcca catctcggtg tattcggcct ccttctccgc gatcgcggtg 33480 gagttttgcc cgaaaatgtt gctcataatc agcaggcatg cttgcgcgcg gttcacgaac 33540 accatcaggg gcggcaccgt cattgtaaaa gctgtttcgt aggcgttcgc tgctaccgtg 33600 agctgggttg cggtcagctc ggcgcttgcg gcgttctggg taagccactt ctcatacggc 33660 gtgacccgct ctgccagcgc cgctgctgac tcaccttcaa atgttgttag taatgcttcg 33720 accgctgact gcaacccctg cgctgcagca gtcagctcct tagccagaac aacccatgct 33780 gcggcagcgg tcaatatcgg gctggagccc gggccgagat acatccgggt ggagttggtc 33840 tcgggcgaca gcgctgcgaa atcgaacatc tcgtcgctcc cttattactc gttggtagcc 33900 actcgtgtgc agctagcgac gtccgctata aactatcgtg attggcagtc tcggtacccg 33960 catatgctga cgagctcgtc aacaagctct ggattagatc ctgatgattg gtcgcgccct 34020 gagaggcgtg cgcctggtac tgtctcccat ggccactgaa aaaatgtgct agcaagattg 34080 acacatcatc ggcagctggg ggagcaattt cagtggtcag ctgggccgcc gcggcgttgc 34140 ttgccactgt ggcagcactg aggccctcca aggtgttagc tgccgcggtc agggcctgtg 34200 gctctgcatt caagaaaagg ggcatgcggt tcctcctcga aactcaaaca atccgactac 34260 tgcacgggga aagctcaagc gacctgctca cctgcgcctc ccttccgact gcttggtggt 34320 acgaactggc cttaatgatc tccgttatgc aacgtttaca acaggttaag agtttataac 34380 aggttaaaac cacccgagtt gccgcagttt aaggtgcaaa gtgcacccat cgacccggca 34440 aaaggttaat tccgtctaaa caaataaaca ctaggtaaac agcactcgaa agatttgtaa 34500 aattgggcaa cagtatgcat gctccgtcac cggtgtaatt gccaggtatg cttccccgcc 34560 cggagcgatg ggtacaccac ccgcagcgga tcctagttat gcgatatatg acgcctaaaa 34620 cgattatcgt taccggtgtc agtggcggca tcgggctgcg acgactcgtc ggttacgtcg 34680 gcgaggcgaa acactacttg ttgtagtggt ggtggaccgg taggtaagca ggaccgccgt 34740 cgtggccacg gagttgggca cggactatac ttaggtgttg ccttctccga gctgtgctgg 34800 ccacatgaac tttccttcgt aaggtcacca tcactgactt gaaaagtgcg gatcggagtc 34860 ggcctaacac tggcctatgt gctcgtgaag ctggaattta tcttgttcac cagggaattg 34920 catcggcgtt accgttttga cggggctctc ggttgcttaa actcatattg tgcagcacag 34980 gccggtggag cgatttgtcg tggccgtaga ccagaactcc taaccagttg gtctagttgg 35040 ttaccaccac gcccggtgtg gattgggttc ctggcgaaat actataatcg aagtacaagt 35100 atcgcggaaa tcaatcgcgc agcctacgac ctaggttttg cgtgtctatt ttgagatcgc 35160 acactggccc agatcaccta acaactccag cgagtgatca cccgtcagaa atcgcatacg 35220 ctgaccccaa aatcgataat tctccttatg attgcacggt ttcgcaggtc attgtaggcg 35280 ttgttgatgt tgtataaacg ttagtgcttc gtgatcatct cgtctagctg tacttggcct 35340 gtctagggta gatcctggcc agtcggaaga tgtcctcctg tgggttgtgt gaactaaaga 35400 cgttgcctgc gagcattttg ttcatcgggg tcaagtcctg aagatcaatc ttgattggcc 35460 aagtcagttg cgaggccatg ccggtgagta cggagacccc gctcttgcag ggtagcatta 35520 gcgcgtagtg gacgttgtcg ctgacgatca acaaaggcga gatgacaacg gcgtcagcca 35580 ttattccata tgtcagatgg cgtaacagat ttagtgcgtc gaccactatt gcagctttgt 35640 gggtagcgct gagctgccgt gctaattttt gcttgaattc gcctcgatca acagagacca 35700 tctttgcggc gcctccgatc cgggtgctct ggatcgcact ggtttggatt cctccggtac 35760 cgcctgagtg cattccggga cagtttgcaa ttgaatcgta gccggctgta atggcgcacg 35820 acagtaacgc gcttggtgcc agtggccagt ggtaagtggt ggttctgtct tcacgagtga 35880 atccctagat accacagtgg tgttttgtga agggtttccg acattggcac agatggccga 35940 ggatcaatca tcggcagtgt gatggcggaa tgtgccgtcg gtaggcatgt ccggcgttaa 36000 gacggtggcc ccgatgtcac agatgtactc cattgtgttc gcacaccagc gggactggca 36060 gcacactgcg cccagcgata tcgtcaaggc atcgtgccag ccgatcgtcg ggaacatgag 36120 tgggcagctc gagggatcga agcgctttat tggatgcgga cagatcctct ttgaggatgt 36180 ggtcatcgga gtggcacaac caggaagcaa ctatctcgac cgggacttcg ccggtccacg 36240 gcgggtctag ttcacattcc tcaccagacc acggtccgcc gacgtcatgc aggatagccg 36300 cccgactcct catgctgcct ttctatacgg acgtgaaagt gaccaggaag tctattgggc 36360 tatcaggtaa ggtcaacccg acaattctgg actttttatc ctttccatgg ttgccaacaa 36420 gggcctagat ttagtgatgc gatcgaacaa gttgttcaac atcacccgtg tgtccagctg 36480 tgctaggcct atccctaggc acatgtggct cccagccaag gtggtatgag cttgccgtgg 36540 ccagtggatg tcgaaggtgt tgggctcggt ccaccggctt ccatcgcggt tggccgagcc 36600 catgagtatg tcgactcctg cgttgggaag gatggtcttg ccgcctattg cgagttaggc 36660 aattgtaatc cgggtgactg aggcccagtt gggggtttcg gaccgcgagc cttcttcgat 36720 cgcgcttgga atcagggacc ggtcctaata accatcgcca gctgctcggg gtggatgtag 36780 ataatccggc ctgaactggc ccactgctac gtcaacgagc gtggtgatca agccgcctcg 36840 gagcgcgcca gaagtgttga ccatctgcgg gctaatcggc gtcgtcgtcg cgaacttgcc 36900 ttcgcggtgc tcggccgctc gctgatctgg gtgaacagct cgccgagcaa gggcggggat 36960 tgctcgtcgc tgtttcgaat gccgagagtg ccgctaaagg aattatacag ttggccgcgt 37020 ctatcgtgtg ctggttccat tcggttctca gccaatgtaa ccggagtgcc ctcaccaccg 37080 tctgcatgga tatcccggcc gcggcaccga tatccatgcc cgggcccaag acccgtcggt 37140 gatgccttgt tccacgatgt cgcggatcaa ttggtagagc ggagggaggc acgtgcgcgt 37200 attcgcgggg acgggtctcg tccagatgca ggttattaga gactcaacta cagattttag 37260 cgtgttgtcc tgagtgcttg attctggctg tgtgctgatg ctgtcgatca tcagttcagc 37320 gtggcggtgc tgtttagtct gcgggtcgca gcgtgctgca agtgtgccga ttgcgcgata 37380 atcctgtcta acagtgctag cagcaattcg tttttgctac tgaaatgctg gtaaaatgtg 37440 cacagcgcgt cttggagcgt gggaagactt cttgcacggt gaagtcggcg tgttccgatt 37500 ttgctcagta tttctactgc tatcttgatt ttacaaagtg gtcggcgcgc gctatctttc 37560 gacgtcatcc gctctggtcg tgggcctctc actcaactct aagaccgacg ttcatctctg 37620 ggaatgcggt tacagtattt tgttgcggcc ggtagtgcga atcctcgcct cggtagttgg 37680 ccccgctttg ctcgatttgt gttgtggctt aacgattttg agtattgttt gctttttctt 37740 ggtgcggcgg caatgcggtg cgcccgcatg gtgatgcgcc agcccggaca aatgagctgg 37800 tgccgacaag aacctacgga actgtacatt tggcattgcg gaaaatctac gaaaccgtat 37860 ttgcaagcaa cagtcgacaa ctgtaatatt ctcccagcct tatagtgtgg atcacgtata 37920 caattttgtc agggaagctt gaatgacgaa ggtttggacg gtagccgaga tggagatgat 37980 acgtaagagg tatcgatggt gacagtgcga ggggtgaaca aaggattggc gttgaacagt 38040 tcgtcagtgc caactttggt tgatgctcat gttgttgcgg tgcctgctat tacgcgcaga 38100 gcggcgagtg gcggttgatg ccgagctttt tcccgcaagt gactacgaac gtaaagtcca 38160 ttcgacagtt gaggtttatt tttctttggc tagtggagac aggcgatggg gctgacgact 38220 cctgctgatg ttcataatgt tgcgttctct taagccacgc atcggcaaac gtggttacag 38280 cgaagaatga ggtcgatctc tttcttgacc tcattgagga agaggtggtc agccatatcg 38340 agaggaatgc tgagctccgt aatcgtgttg ctgggctaga caagcggaac accaggctcg 38400 ctgacggaca agtcgagctt gcacagcggt gcactgctgt cactcagcgg gaacggcaag 38460 ttggtgaaca agaggcccgg ctgtgcccgc aagaagccgc gatcgcccgg cgggaggtcc 38520 ggctgcgtca gcaagaaacc gagtttgccc aacggcacgc tgttgtgagt gaaggtgaat 38580 ggcaagttag ccaacaagag gcttggctct acgagagcaa gaaactgaga ttcgtgagcg 38640 gcaggaccga tcagagtcga tccgtccttt tgcgtcaacg gtgatgcagc tatttaccat 38700 atgacgcagt cctctcactc tgtgcctcaa tgcattgcgc cacatctgca gcacgtcgtt 38760 acccatggtt tgcttcgctc ctagagtggg cggacagtaa gcgcggtgca tggtcggcac 38820 cgcatggagc ggacagccga ttcgggcggt gaccgacata ctcggtaaca ggatggctga 38880 gacggtgtgt gagtgtatgc gcacgagtac ggttcaaccc acgccagtgc gtaattgcct 38940 aatgaggtgg tctctccatt gcaggatctc atgcgcgaga acgccgaatt taaccgatcc 39000 aacggcattc tcaaagctgt ggcggctctc cttgctgctg agcttgaccg gcactaagtg 39060 tgttgtggcc tgcggtgcga tgatcagctt cttcgggctg ctgtcaccgt tgagcggttc 39120 accttatgtt gtcactgtgt gtggaatctg gtcgatgaat tccagcgttt tcggaacttt 39180 gtatctgtca agcttgctct ttgcttagtc gatcacctgc tgctctgtcg acggcacagc 39240 cttgtggtta gcggagtagt ttgcaccacc gcgtgcgcac cttgcatccc cagcgcgagt 39300 cggccatttc gacgaccacc acgtccggca gatgcctgag tgtgtggcaa gggcagactc 39360 gacttcgact ggaaagacgc tggtgccgcc ggtgatgatc atgtcggcaa ggccgtctac 39420 gatgtcgatg tggaagtggc catcggatta caggtggcgg ataatcgcca aattaaagga 39480 atccaacgtc ggttgacggt agcggtaaag ccccacccag atagcggtag tcagtgctca 39540 tcggtgcgtg cagatacatg tcgccatctt ctaccggacc ccagcggtct ttgttcggca 39600 tctagaattt ggatatcggt attcgagaag tcgcggccta cgttgcccgg atgagtgagc 39660 cactcgtcgc tgcgcaatgc cgtgagtcct cgggttctta gtgcctgtcg taggagatga 39720 caatctgttc gagactgagt agttcgagcc agctatgcaa tagccggttg gcatcacggc 39780 agcgccctgc gaggataaag attaaagatg acgttggaca agtctcgttt agtccgatgt 39840 caggcagggc tacgatactc gccagcatgg tcggcgtggc cgtgaagttg gtaatctgat 39900 accactcgac tatgttcaca accagtgtcg cttcgaactt ttcgggcata accagatggt 39960 cgtctcccat aagagatgag gagggtggcg aagccgtttg gtgtgatgta tcggcacggg 40020 taccaatggc ttgctgcctg gaccactggc gtccaggtcg atcagaacgg ctcgctgtgc 40080 tgagggatgc ggagcgacgg ggctaaatta aggatcacct tggtcgtgtc ggttgatttt 40140 ctgctgaaaa ttcctttttc tgtcgggaaa ttgcttcagg aattgggctt tcggactcgc 40200 agctgagaat atgcataggt gggtgcatgg tagaatagtt tctattcctg tcgcagggtg 40260 cggttatcgc tgtccaacat caccgagcgg ttgtgctacg cagaggacag tggctgtgac 40320 ggaatagcgt tcattgatca tctcgaggtt cccgggctcc atgatgaaaa catctgaaat 40380 gtgatgggaa ttacgacctt ggtagcggtc gggccttagc gctgaagatc ggtcatctga 40440 tgctatgcga cgcgttccgg tatccgacgg tactcgctaa gcacgctatc atcctgccgg 40500 ctgcgttcga cggcaaattc aatttcagtc taggttcgtg gttgtggtcg gcggagttcg 40560 ccagattcga tattatccag taggacccgg tggaccgggt cgagcaattt cggaagccac 40620 ctggcgctga ccacgcagta ttgggctgac ggcgacaaga gtcagcgttc cagaccggct 40680 cgtcggatac tgctggttct gggtggaagt ggtcttctga tgatgtaatt ctttgtcggg 40740 taataggatt ggtggaacct ccaggagaat catattgctc ggttgccccg gctggctcag 40800 gcgacggggc gtactggatc tcggtgcagc agatagcggg ctttgttagg tcaagtaact 40860 attcggctgc tgtgcatgag ctgaacactc ggctattcgg ccacctgggc ccgggactcg 40920 tctgtggtga cgccggatga attgatcgca cacttcgcgg gcttgacgat ttatcgggtg 40980 gagcttttct acgtgtggtt tgccgatttc gtagtcggtt tcgctgcgcg agttcggtga 41040 attggtgatc aaagcattcg gccgagtgga acggcatcga gtttcggtcg gggcacggtc 41100 tgtggccgag cgaaggggcc gcgctgtacc gaccgcactc agccggatct ccggcagttc 41160 caatgatgaa tgggtcgacg gtgtctaatt aggcaacagc tttggtgacg ttagacacct 41220 ggattgcgtc caccttgacg gggacgtcgg tcagcatctc ggttttacct gttctggccg 41280 tcacgatgtg gacgtcgatg ccattccggt cgacttcgcg ccaatgcccg ggcgaacgta 41340 ttcatgccgt ctttggatgc cgagtaggga gtccttttgg ctggtatagg ctcgtgtgcc 41400 gctgacgacg agataaacat caaccgcgaa tccgcacgca tcagcggcag cggtcattac 41460 gaaacacaaa tccagtctgg ccgagccgat tgcctgccat tgctcgagtg tttgcttgtg 41520 cacgtatgtt tcccagctta tcggccttgt gaaagataag gtcgaccgat tccagtgtgt 41580 ttatggcatc aggtgattcc gctgtatcgg atgcttaggt cacgatatgg tggttcacga 41640 tctctacgga gcgtagcaag acttgacgtc gctccgccaa catcatgtcg tactttagct 41700 cacatagcct gcgaacacat gctttcctga ccctgtcgtt gctgtcggtg agcagtgcgg 41760 ttctggtgtt caagggcgcc gaatatcttt cggatgcgac aattcctgcg gtgaaagcgc 41820 atagatccgt tgttcgtgtc cagcttgacg acacattagg tctgggtgtc ggccagcggt 41880 ccggcgtgcc cggtcgacgt caccttcggt gatcgtctca gcgaacttga tatgcgtgtt 41940 gagcccggca cggcgcttcg ccagcgatgg gtaagttccc cgcgctgagc tctcgttcga 42000 ctactgccgt tcatggctgg tccacagcgt ctctaagctg cctactaccg cgatgtatgg 42060 tgtagttgcc gcggacgatg agatcgtgga atcgacaccc atttcagtga agagcaggct 42120 gtcttcgggg tgcatagcga tggaatcatt gattttactt aagttttggc actaagaata 42180 tcctcgcggt cgtgctactg ggctgccagt gcggcgcagg caggttcgag ttcctgtaat 42240 gccgcgccga ggtcggcgag cgcgattgac ttactctgca gcagtaaacc aagcatgtaa 42300 gcggcgctgg tcctggttgg tgtgtgcaca acgacgctgc cacggttgcc tcgccgtaac 42360 gagattagcc tctcagtgtc catgatctgc agcgcttccc gaaatgagag caagctgacg 42420 tttaacggtt cgacgagcgc ttcctggcgc ggcaacaggt tgccgtcgat gatctggcag 42480 cacagctcgt tcagctacga tttcgtctat cctcggtgtc gacaaccggc gacgggcgtc 42540 gtcaccaagt gctaaggcga tgatctgatc ctcgcaactc gatttaattt aatgatgtaa 42600 tttattacat ttagtgattt aatttttacg tggtgacccg cggttcttgc tttagctaat 42660 ttaacaatta tattgtaaat agttgcgtga gttgcgggtc cgacatccgg tcgatctcgc 42720 ttgactagtt gtgtattgtc gagatcaatg acctgattgt cggcagttat tgcagcaaac 42780 tgttggtcga cgttggcgca gagctacgta aagtcaaact gttgcaaggt gattttgttg 42840 tttcggtggc taccatcctt ggatagccgg gatttcccgt tgttcagcta tctcaacgtg 42900 ggcaggcgca gaatgacctg ttgggtggat tccgacctat accgcgccgc actcgctgcc 42960 ccgaacgtta tagtgctcac cgaaagctga tcgcgggcag tggccctggt aatcgatccg 43020 cagcggctgc taagcgtctt tccgcaggtg atcatagtca tgatctccga tttcggctga 43080 atcggtctgt tcgctgatca cgcggcaacc gagttaatgc tgcagagcct gggcctactc 43140 gcctgccgat cgatcgggga gtatgtgggc ggcgtgttag gtgcactggc cgcgcgacgc 43200 cgcctcgagt atggcgatcc gggtgagaaa tcgcgacctt gtccaaactc gaggcgatca 43260 cgttgatgca gagtagcaaa tagctgcatt ccgcagttgc tgcgagttcc tccggtccgc 43320 cgctctctcg aagtacccta cgatcgaacc gacctggtac ggctaaggtg ggatcaccat 43380 ggccacgaag tccagccatg gctggacttc gtggccatgg tcgactgccc tgaacttggc 43440 ggtattccgt agctgcggtt tcagatcagc cgatgggaat accgcaacct gatcaaggaa 43500 cggattggtc cctgaatggc agaatgaatc atctagtaga tcgtcggctg ggctaactgt 43560 tctgcctacc gatctcggcg caggggtaac ggttacactg cccgagagac ggcccacctg 43620 atcgaccgcg gggtgttggt tcgtaaccct ctggttttca ccagccgctc ctgtcatggt 43680 tgagtcaagg tgcgtatctg cggtgcttgt ccgcaccaca gcacgctgtg cgggcaaaga 43740 gatatagcca tggtaaaatg tggatctaca tgtaaaatgg cggcgcaaag attgcatctc 43800 gagacagttg tcgttgtcga tttggttact ttttgggtcg ggtccgttgc tatccagctt 43860 ctctgctagc tgtgttcggt gccgacgtag tcaaggtaga gtctatccag tgtctctata 43920 ggcattcgct aattggtcgg aatgcacact gaagtcgaga actggtggta gtacggttaa 43980 gtattccatg cgatgaactc aattccgtta agttggggga ggatgaatcg acatcaacct 44040 tgatggtacg catccagtac actatgatat cggggttcag tgcagaactt cctcaacggc 44100 gctggggtgc aatgcttcct gatcgcggta tcgttttatc tggtcgggat tcgtggtgaa 44160 cgcctgcagt ccaatagcca gtagtgtgct tggcggtgtt gctgccggtg aaggtgagca 44220 cgaagaagaa ttctagttcg ttggcgggaa gacggaatgg tttttcgtca ttcccggtga 44280 tgacggccga tgccagcgtc cgccagatgt cgtcggatgg gttgcgtcgc ttttccgcgg 44340 tgagtttgag tgtgtactca aagatggtgc tgtggagatc gatttccttc cgccggctca 44400 gccaggcttc tggcgatcga gccttcagga ttcggtcaaa ggaatcaaaa atctgcggcc 44460 ggttcttttc cagcatgccg atgcttgacc gtcacccaga agtggtgttg agtggtcact 44520 gtagcaagcc gagcgaaacc gggtgtgaac tagcgcccgg aaagcggcct gttgcgtctc 44580 aggtcggcaa acaaatcatc agaaaaacta tttataacat aatatcggat atatttactg 44640 tgacagcggt aattgccagt ctcgattcgt tggagtgtcg caccaccacg gcgttgattt 44700 tcaatatttg aaatactaga aatagactct agtcgtcgaa ccgctgtcag tggggtggcc 44760 ccgtttgcgt tcggttgtgt ggtatacgga gtgcaccgtg acgtatactg ttttggacta 44820 gattgttgag tcgggccaag gatgcgtcag aacggaagtt cggatcgacc ggtattgcgt 44880 tgtcgactta ccggttctcg acgggttggt tcatcgtcgg attttcctcc gacttgaccg 44940 tcggaagagg aggataagca aagatggcga tgatttgtca ggaatagcga gtactcgatg 45000 cggtgactgc tcgtgcggcc attctgtatg tgaccgctca acaaaatggt gtatactttg 45060 acggcgatcg tgaacactgg ctcgccacct tgccgccatt ccggtgctag ctgcatccgg 45120 agatggcgag ttgtttcgcg atctgcgcgc ttctttcaac ggcgacgatg gatagcgatt 45180 ggtgactgtc gatcacgaaa tcactgtcga aggagtccac gcggtacgat gttgtgtcgc 45240 agcgcatacg gcgatacgac tctgcaggcc acaggggtat tttgggatta actgaattta 45300 cgagcgcggt ggctggtatt tctcttgccg caattttgcc tgggatgcgg taccaagccg 45360 tcatccgctc ggtcatgtgc gcagtaccgc tacgttgctt gacatgaaag ggatttagcg 45420 ctgctatcca tttcagttag tacccaagta ttggaagcta gagttgtcag tcacagaact 45480 agagttgtct gtcacagaag gtgtccaccc cgaccaggag tacggtactt ggctcatggc 45540 tggccacctc gacgctgccg agatcgttca gtcatttgcc tttctgagga tattcaatta 45600 agaatcggcc cggtggtacc gatagtcgcc ggtttctata cgatggtgct attttatcta 45660 cagaccggtg attacggcac ctataaagga ttatggcata ccgcaggcca ccctgaatgc 45720 ggacatacag cgcaatttgg ctaccatcgt atggctgcct aggtcttgaa tatcaaagcg 45780 gagccagagc tgcgtcgtgg gctgtccact gcgacggtga cgaacattac ttccttgttc 45840 ctgccaagtt gatctagtcg gtattagccg ggcgggttga tccatgcaac tggacctgac 45900 cgtaacatca actcgagcat cgacaccagt gtgtgcgtct atttatcacg ggaagatcgt 45960 ctgcttcggc caaaaataca cctactccat atgttcagac cggatggaca atgacccgga 46020 cgttgcgctg gggtgaagtg atcgagtagg tcagcagcac cgatgagcat gtagaccggc 46080 aatggtttcc gaaatatgtg tgcggcgtgg aaaccagggg aggctcgcgg gctcggtctc 46140 aagaatggcg cgcgatcaat ttcgatagcg gcgtctaccc cagtatttgg cagcattcta 46200 ccgcaccaac agtaatgcgt tgcaagcatt ctccggcgtg atgctgagat acccgaacct 46260 agctcatggt attaagtaac cgtctgaatg tgccgaagac atccaggtca tggtgagcag 46320 ctacgtgcga tggccagacg ctgtgcggcc cttggtgtac ccgattgcgc cggttagata 46380 tatgttcgat tatcatcgga tgacttgctg cgcactgcaa ctgtggacat tcttaggaga 46440 gtttttggtt gctgctccag cgcatggcct gccgatcgaa tatgtggacc gtgggacgct 46500 gtggggcaat ccggtgagtg gcttcgcttg ctaagagcgc tcattggcgc tgtatcggga 46560 ttggggtctg atcgatgtgt tggctacgac cgtccctaac gtcgcactag cttactcaga 46620 cctgaagatc acagtggatc aggttgtgcc gttgtcagtt tgagctcgtt gctatgcggt 46680 gcgtgagagg ttgatgaagg tggttcccaa ccaaaagtac tagatagcaa agattctcca 46740 cgatctgctc tccatactat cggaggacgg gtcgcccgac agaaataccg gcagcatcat 46800 gacgttcgga tatgattatg tcaatatgac aaatatgtga ctggtggttt tgacgtgatt 46860 ctttggtgtt tctgacatat cctgtgacat atgtcggttt ctcggcgtga cgtccttaaa 46920 ttcgctaccg tgacaccggg cctgttaggt ctaggtgtcg ctgccgcggc gttgtgcgcc 46980 gtaccggcat cgacggcagg ttcacttggc accttgttgg actacgcggc cggagtcatc 47040 cccgccagcc agatcagggc caccggcgcg gtgggggcaa tccgatacgt gtccgatcct 47100 cggggtacct gggcggttgg caagccgatt caggtcactg aggcgcgtga cctcatcaat 47160 aacgggctaa aaattgtttc ctgctatcaa tatggcaagg gcaataccgc agactggctg 47220 ggcggtgcca ctgccggcct ccggcacgcc cagcgcggag tgcagttaca cactgccgct 47280 ggtggtcccg tcagtgcacc tatttacgct tcgatcgact ctaatcccac gtatgagcag 47340 tacaaacagc aggttgctcc gtatctgcgg tcctgggaat cggtgatcgg gcaccagcgc 47400 acgggcgtct atgctaattc gaggacgatc gcctgggccc tgcaagacgg cttggcctcg 47460 tatttctggc agcacaactg gggctcccct aagggctaca ctcatccggc tgcgaatttg 47520 caccaggtcg agattgacag gcgcaccgtt ggtggggttg gggttgacgt caacacaatc 47580 ctcaagcccc aattcgggca gtgggcttaa gccggtctgg ggctactggc gcgttgaacg 47640 gccttgcctg acgccggtgc ctgtgcactc cggcaaacac ttgttttcgt tcggtgcacg 47700 ggactgtaga cttgtaaaga tgcgtggtgg tacgtacctc gcctctgtag cctcactatc 47760 aaaaattatt tatataaact agcctcactg taatttatat aacagtatga agtattccat 47820 aacaatcttg cctcgatcaa tgcagttata gctacttgac cgtaaccacc tacacgcagg 47880 atgtttgtcc gcagcatccg tgctcgcggt ttgacccggc gttacttaca acatggctac 47940 ccctatatag gatatagaac tcgctagtaa ccactcggcg tgcaagaagg gcacgttttt 48000 gttacacctt atgttttctc ttatgaaatc cttgttgcag ccgatgcagt ctgccgcgcg 48060 gctcggtcca cggccggtgc accaaacaca caccggtcag ctgactttcg gtctgcggtt 48120 taacgtggaa tcgaccggaa actgactggg cttcgcacgg cagtccaggc ggcctggcga 48180 acagacacct tattaaagac gcacacaggg agatatagag cgtgacgatc cacgagcacg 48240 accaagtgtc cgctgatcgc aacggaaata gcctacatgg ctcccgtgct ctggcggatc 48300 ggctaaaggc cggagaaccg tacgtcgtcg cgttcggtgg ccaaggcagc gcctggctag 48360 agaccctgga agaactcgtg tcctcggctg ggctcgaagc cgacttggca acgttggttt 48420 gtgaggtcga attgctactc gaaccggtcg ccaaagagct ggttgtggtg cgtccgatcg 48480 gtttcgagcc gctgcagtgg gtacgcgcgc tgttggccga agacttggta ccgtccgaca 48540 agcacctgac gtcggctgcg gtgtcggtac ccggcgtgct gctcacccag atcgcggtcg 48600 ggcgcgctct ggcacggcag ggcatggacc ttatcgcgac acccccggtg gggattgtgg 48660 ggcattccca gggggtgctc gctgtcgagg cgttgaaggc cgggggggca cgcgacgctg 48720 agctattggc aatggcccag ctgattggtg ctgccggaac gttggtggcc cgccgccgcg 48780 gcatttccgt cctcggcgac cgtccgccga tggtgtcggt caccaacgct gaccccgagc 48840 ggattcgccg gctgctcgat gagttcgcac aggatgttcg cactgtgcta cccccggtgc 48900 tgtccattcg caacgggtgg cgttcggttg ttattaccgg cactcccgaa cagctgtcgc 48960 gattcgagcg ttactgccgg cagatctccg acaaggagga ggaggatcgc aggaaaaaga 49020 tccgcggtgg tgatattttt gcgccggtct tcgatccggt gcaggtagag ataggcttcc 49080 acacgccaca tctggccgac ggtattggca tcgtcggagg ctgggccgag aaagtcggcc 49140 tcgatgtcac gttggcccgg gaactgactg aggccatcct ggtgcgcggc gtcgactggg 49200 tgcgcgagat tacccgggta catggtgctg gcgttcggtg gattatcgat ctgggtcctg 49260 gcgacattct gacccggctg actgcgccgg tgattcgcgg cctcggtgtg ggcattgtgc 49320 ccgttgcaaa tcgaggtggt cagcgcaccc tcttcaccgt cggggccgtt cctgaggtgg 49380 ttcgcgcttg gttgagctac gccccaaccg tagtccaact tcccgacggc aggatcaagc 49440 tctcgacgaa gtttacccgg ctgactgggc gttcgccgat tctgctcgcg ggcatgaccc 49500 cgaccaccgt cgatgccaac attgtggctg ctgcggccaa cgccgggcac tgggccgaac 49560 tggccggtgg tgggcaggtc acggaagaaa ttttcgccaa ccgcgtcgag caactgtccg 49620 gactgctcga gcctggacgc acctatcagt tcaacgcgtt gtttcttgac ccgtacctgt 49680 ggaagctgca agttggcggc aagcggttgg tgcagaaagc ccggcagtct ggcgcagcga 49740 tcgacggtgt ggtgataagc ggcggtattt tagatttgga agatgccgtc gagttgatcg 49800 aggaactggg tggcatcggc atcagctatg tcgtgttcaa acccggcacc attgagcaga 49860 tacgctcggt gattcgtatc gcgaccgaga tgtccaccaa gccggtgatc atgcatgtcg 49920 agggtgggcg tgcaggcggt catcattcct gggaagacct cgatgacctg ctacttgcca 49980 cctattcgga gttgcgctca catgccaaca ttactgtttg cgtcggcggt ggcattggca 50040 ctcccgaaaa ggcggcggag tacttgtccg gacgttgggc gcaagcgtac ggcttcccgt 50100 tgatgccgat cgacggtatc ctggtcggca ccgcggcgat ggctaccaag gaggccacta 50160 cctcgccatc ggttaagcgg atgctagtcg aaacgcaagg gaccgaccag tggatcggct 50220 ccggaaaggc ccagggcggc atggcttcca gccgtagcca gctcggtgcc gacatccacg 50280 agattgacaa cgctgcctcg cgttgtggtc gactacttga cgaggtcgct ggcgatgctg 50340 aggcggtcgc agaacgtcgt gacgagatca tcgcggcgat ggccaacacc gctaaacctt 50400 attttggcga cgtttcagag atgacctacc tgcagtggtt gcagcgctac gttgagttga 50460 cgatcggcga gggtaactcg accgccgaca ctgcgtcacc gggcagccca tggctggccg 50520 atacctggcg tgaccggttc cagaaaatgt tgcaaagagc tgaatcacgt ttgcatccaa 50580 gtgatttcgg tctgattaag acaattttta ccgatcctgt gttactagag aaacccaacc 50640 aggctatcgc cgctctgctg aagtactacc cagacgccga aaccgtccag ctgcacccgg 50700 cggatgcgcc tttcttcgtc atgctatgcc agatgctggg caagccggtc aacttcgtgc 50760 cggtcatcga caaggatgtg cggcgttggt ggcgtagtga ctcgctgtgg caggcgcatg 50820 atgctcgcta tgacgccgac caggtgtgca tcatccccgg cattgcagcg gtggccggta 50880 ttacacagat ggacgaaccc gttggtgagt tgctggaccg cttcgaacag gccgccatcg 50940 acgaggtact cgccggcgga gcggagccgg tggtggttat gtcgcgccgg ttgggccgtg 51000 ccgatgtggc cggacctctg gccgtggtgc ttgacgcacc cgatgtgctg tgggccgggc 51060 gcatcgctac caacccggtt catcggatcg ccgatccgaa tgagtggcag gttaatggaa 51120 acctcagtgc gacacactca tccaccggtg cccagttgca ggtaaagtcc gaagaccagc 51180 aggtagttct cagcgtcccg gtgtcgaacg gttggatcga catcccgttt acgttgccta 51240 ccaacaccgt tgacggcggt gccttgctgg tatccaccga ggatgccacc agtgccatgc 51300 gcgcagtgct ggcaatcgtc gctggtgttg acgggccgga gttgctgtcc ccggttaaag 51360 acggaactgc tatagtcaca gtggactgga atcctgagcg ggttgctgat cacaccgggg 51420 tcacggccac cttccgggag ccgctggctc ccagtctcgc cactgtgccc gacgcattgg 51480 tcggtgcatg ctggcccgcg gttttctcgg ccatcggctc cgcagttacc gaagccggtg 51540 ttttggtggt ggagggcctg ctgaatctac tgcacctgga ccacgctgtc tgtgttgttg 51600 gcaagttgcc aacagttcca gcccaattga cagtaaccgc aacggtttct ttggccatcg 51660 atacagacat gggccgtgtc gtgcccgtct cggtgaccat tagagacaca accggagccg 51720 acggcgctgt gcttgccact ctcgaggagc ggtttgtgat cctcggacgc accggcaccg 51780 cggaactcac cggcccggtt cgggctggtg gagcaatatc tgagaacgcg accgacactc 51840 cgcgccgacg gcgtcgtgac gtcaccctta ccgcaccgat tgatatgcgt ccgttcgcag 51900 tggtgtccgg tgaccacaat cccattcaca ccgaccggac tgctgcgctg ttggcaggct 51960 tggaatcgcc gatcgtgcac ggcatgtggt tgtcggctgc agctcagcac gtggtaatgg 52020 ctaccgacgg acaagctcga ccggcggcgc gattgatcgg gtggactgca cgattcctgg 52080 gtatggccca tcctggcgac aaggtcgact ttcgtgtcga ccgcattgga atcgaccagg 52140 gagcagagat tttagaggtt agcgcgcgca tcagttcggg tctggtgatg tcggctaccg 52200 cacggctggc cgcgcccaag actgtctacg cgttccccgg ccagggtatc cagcataaag 52260 gtatgggcat ggatgttcgg gctcgttcca aggcggcccg cagggtgtgg gacgatgctg 52320 acaaatttac tcgtagcggg cttgggtttt cggtcctgca cgtggtgcgt gacaacccga 52380 ccaatatcac cgccaacggt gtacattacc accatcccga tggggtgttg tacctcacac 52440 agttcaccca agttgcgatg gctacggtgg cggtcgcgca ggttgctgag atgcgtgaac 52500 agggtgcttt tgtcgaaggt gctatcgcct gcggccattc cgtcggcgaa tatacggcat 52560 tggcctgtgt catgggagtc tatgagctag aagccttgct agagactgtg tttcaccgcg 52620 ggtcgaagat gcacgacatc gtgttgcgcg acgaactggg ccgttctaac taccggttgg 52680 cggcgatccg accctcgcag atcggcctgc ccgatgatga ggttcccgcg tttgtcagag 52740 gaatcgccga aagcactggt gaattcctgg agatcgtgaa cttcaacctg cgtggctcgc 52800 agtacgcgat tgccggcacg gtccacggcc tggaagcatt ggaagccgaa gtggagcggc 52860 gccgtgagct caccggcggt cggcgctcat tcatcttggt gcctggcatc gacgtgccat 52920 tccactcgcg ggtgctacgg gtcggcgtgg cagaattccg ccgttcgctg gaccgcgtcc 52980 tgccgcagga tcaagatccc gactggatca ttgggcgcta catccccaac ctagtgccac 53040 ggccgttcac actggctcgc gacttcatcc aggagatccg ggatctggta cctgccgagc 53100 cactcgacga tatcctcgcc gactatgata cctggcgccg tgagcgcccg agtgagatgg 53160 cgcggcgggt gttaatcgag ctgttggctt ggcaattcgc cagccccgtg cgctggatcg 53220 aaacgcagga tctgttgttc accgaagagg ccgctggcgg cctcggcgtg gagcggttcg 53280 tcgagatcgg tgtgaagtcg gcgccgaccg ttgctgggct cgctaccgat acccttaaac 53340 ttcctgaata ttcccacaac acagtcgaag tgctcaacgt cgagcgtgac gccgcggtgc 53400 tgttcgccac tgacaccgat cccgagctag agccggagcc agaaaacgta tcggacgctt 53460 ccgccgcttt accggcagaa agcgcgttag cgctgggaac tgttgcgcct gctccggtgg 53520 tgccgtcggg tcctcggccg gaggacattt cgttcggcgc cgccgacgct acattggcgt 53580 tgatcgcgct gtcggccaag atgcgcctcg accagattga ggagatggac tcgatcgagt 53640 ccatcactga tggcgcgtcg tcgcggcgta accagctgct ggtagacttg ggttctgagt 53700 tgagcctggg cgccatcgat ggcgtcgccg aggcggatct agccgggctg cggtcgcagg 53760 tgactaagtt agcgcgcacc tataagcctt acggtccagt gctttctgaa ttgattaatg 53820 atcagctgcg ctcggctcta gggccctcgg gcaagcggcc cggcgtcatc gccgagcggg 53880 tcaagaagat ttgggagctc ggcgatggtt gggttaagca cgtaacggtc gagattgcgc 53940 tgggaactcg tgagggcacc agtgttcgtg ggggacccct gggcaacctg aacgagggtg 54000 cgttggccga tgtcgactcc gttgacaagg ccgttgacgc ggcggtcgct tcggtcgctg 54060 cgcggcatgg cgttgtggtg gccctgccgt ccgcgggcag tggaggaagt gcgaccgtcg 54120 acgttgcagc attgagcgaa ttcaccgatc agatcaccgg acacgacggc gtgctcgctt 54180 cggcggcccg tttggtattg ggtcagctgg gtctggatgg acccgttact gcggctccag 54240 ctaccaccga caccgggctc atcgatttgg ttactgctga attgagtacg gactggcccc 54300 gtttggtggc tccggtgttc gacgtcaaga aggccgttgt tttcgacgac cgctgggcta 54360 gtgcccgtga ggatttggtc aggttgtggc tgaatgacga gggtgagatt gaagcccagt 54420 ggtcgcatct gtcggaaagg ttcgagggcg ccggccacgt cgttgctacc caggccacct 54480 ggtggcaggg taagtcgttg gccgcgggtc gccagatcca cgcgtcgctg tacggacgga 54540 tcgctgccgg tgcccagaac ccggatcgag gtctctacag cagtgaaatc gccgtcgtta 54600 caggagcttc aaagggttcg atcgccgcct cggttgcagc acgactgctc gatggcggtg 54660 ccactgtgat agcgacaacg tcgaagctcg acgaggaaag gataacgttc taccgtgcgt 54720 tgtaccgtga ccatgctcgg tacggcgccg cgttgtgggt ggtcgcggcc aacatggcat 54780 cctattctga cattgatgca ctggttgaat ggattggcaa cgaacagaca gaaagccttg 54840 ggccacagtc gattcacatc aaggatgcgc agacaccgac gctgctgttc ccgtttgcag 54900 cgccgcgtgt gatcggtgac ttgtcggagg ccggtgcacg ctccgagata gagatgaaag 54960 tgctgttgtg ggcagtgcag cgactgattg ttggtctgtc gaagatcggc actgagcgcg 55020 atgtcgcgtc gcggctgcac gtggtgttgc ccggctcacc caaccgcggc atgttcggtg 55080 gcgatggggc ttacggcgaa gctaagtcgg ctttggacgc cgtggtgagt cgttggcacg 55140 ccgagtcttc gtgggcggcg cgggtcagtc tggcacatgc gctgattggc tggactcgcg 55200 gcacggggct gatggggcac aacgacgtta tcgtcagtgc tgtcgaagag gcaggcgtta 55260 ccacgtactc caccgatgag atggccgcaa tgttgttgga cttgtgcaat gcggagtcca 55320 aggtggctgc ggccggcacg ccgatcacgg tggacttgac cggaggcctg ggtgaggttg 55380 atctcgacat ggccgaacta gccgccaaag cgcgtgaaga tcatgcggcg caggccgcag 55440 aagatgaagc aactgaagcc tccgaggtag cgggcacgat tgccgcgttg ccctccccac 55500 ctcgcggcta cactccggcg tcgccgcact gggacgacct tgatgtcgac cccgccgacc 55560 tggtggtgat tgtcggtggc gccgaaatag gcccgtacgg ttcgtcgcgt acccggttcg 55620 agatggaggt tgcgggcgaa ctgtcggctg ccggtgtcct ggagttggtc tggaccactg 55680 gattgattcg gtgggaagac gacccgcaac ccggttggta tgacaccgaa tccggcgaat 55740 tggtcgacga gtccgaatta gttgaacgct accacgacac cgtggtgcag cgttgcggca 55800 tccgtgagtt cgttgatgat ggcacgatcg atcctgatca tgcgtacccg ctcctggtct 55860 cggtgttctt ggacaaggac ttcgcgttcg tcgtctcctc ggaggccgac gctcgtgcct 55920 ttgtcgagtt cgatccggag cacacggtta tccggccggt gcccgactcg agcgactggc 55980 aggtcatccg caaggccggc accgagatta gagtgccgcg aaagatgaag ctgtcacggg 56040 tcgttggtgg tcagatcccg accggattcg atccgacggt gtggggcatt agccccgaca 56100 tggtcagttc catcgacagg gtagcggtgt ggagtatcgt agcaactgtc gatgcgttcc 56160 tgagcgctgg cttcaccccc gccgaggtga tgcgctatgt gcacccgagt ttagtggcca 56220 acaccatggg caccggtatg ggcggtggca cttcgataca aagattgtat cacagcagct 56280 tgttgggtcg taacaagccc aatgacatct ttcaggaaat cttgccgaat atagttgccg 56340 cgcacgtagt ccagtcctat attggcagct acggatcgat gattcacccg gtcgctgcat 56400 gcgcgacggc cgcggtgtcg gtcgaggagg gtgtcgacaa gatccggctc ggtaaagccg 56460 agctggtggt agctggcggc atagatgacc tgacgttgga aggcatcatt ggcttcggcg 56520 atatggcggc caccgccgac accgccatga tgcgtggccg gggcatccac gattccaagt 56580 tctccaggcc caacgatcgg cgtcgactgg gtttcgtcga agcccagggt ggtggcacca 56640 tcctgctggc gcgtggtgac ctagcgctca agatgggtct tccggtgttt gcggtggtgg 56700 cgttcgccca gtcgttcggt gacggtgtgc acacttcaat cccagctccg ggcttgggcg 56760 cgcttggcgc aggccgcggt ggcaaggatt cgccgttggt ccagtcgctg gccaagcttg 56820 gtgtgtctgc tgacgacatt gcagtgatct ccaagcacga cacttcgacg ctggccaatg 56880 atcccaacga gaccgagctg catgagcggc tcgctgacgc gatgggccgc tccgcgggtg 56940 ctccgctgtt cgtggtgtcg cagaagagcc tcacaggcca cgccaaggga ggcgcggcag 57000 tcttccagat gatgggcttg tgccagatgc tgcgggatgg ggtaatcccg cccaaccgca 57060 gcctggattg cgtcgatgag gagctagctg gtgcggcgca ctttgtatgg ctacgcgaca 57120 cgctgcggct cggcgaaaaa ttcccgctta aggccggcat gctgactagc cttgggttcg 57180 ggcacgtgtc gggtttagtg gcgttggtgc acccgcaggc gtttatcgcc gcgctagacc 57240 caggtcagcg ggacgactac cagcggcgtg cgaatgtgcg cctgctagcc ggtcagcggc 57300 gtctggcttc ggcgatcgct ggcggtgcgc cgatgtacga gcggccaccg gaccgtcgct 57360 tcgaccacca tgtgccggag aagctgcaag aggcagcgat gttgctcaat ccggctgctc 57420 ggcttggtga cggcgatgct tatatcggat gagttcggtc atcggttaac gtagcacttc 57480 gtgggcattg tcggcgtggg aatcgacctc gtctccatcc ctgatttcgc cgagcaggtc 57540 agccaaccgg gaacggtgtt catgactatc ttcactcctg gtgagcgtcg cgatgcctcg 57600 gtcaagagtt cgtcggcggt gtgtcacctg gcggcgcgtt gggctgtgaa ggaagcggtg 57660 atcaaggcgt ggtcaggatc gcggttcgcc cagcgaccga tgctgccaga gaacatccac 57720 cgcgatatcg aggtagtcaa cgacatgtgg ggccgtccgc gggtccggct caccggagcc 57780 atcgctaagc atctgacgga tgtgacgatc catgtgtcgc tgacgcacga aggggatatc 57840 gcggcggcag tggtgatctt ggaggttctg tgagctgggg tacctccccc gtttgtgggg 57900 aggtacccca gccgcctgcg gcgcaagctg gcgtgcagta gacgctggac tagcctcaag 57960 ccatgagtga tcttattgag cgtgttcgtg aagtgctacc gttggtacga cgcgaccttg 58020 agaatttggt ccggatcgaa tcggtgtggg ccgatcctgg ccggcggaat gaggtgcacc 58080 gcagcgcgca agtggtctta gatctgttgt cgcaagcggg ttttaacttt gtgcgtatcg 58140 tcagtgaggg tggtgcgccg gccgtcattg ctcggtatcc ggccccactg ggaacgccca 58200 ccgttttgct gtatgcccac catgacgttc agccggaagg tgaccgcgac cagtgggcgt 58260 cgccgccttt cgagcccact gaacgcgacg ggcgaatcta cggtcgcggc agcgccgatg 58320 ataaagcagg cattgcaacg catttagctg cgttccgggc gcatggtggt cgaccgccgg 58380 tgggtgtgac agtcttcgtg gagggcgaag aagaatccgg atcgccgtcg ctgggcaggt 58440 tgctggccgc ccaccgcgat gcgctggctg ctgacgtgat cataattgcc gactcggata 58500 actggagtac cgatgtccct gcgctgacgg tgtcactgcg tggcttagtc gactgcgtcg 58560 ttgaggtcgc cacacttgac cacgggctgc attccggatt gtggggtggc gtggttcctg 58620 acgcgctgag tgtgctgatg cggctgctgg ccagcctgca cgacgacgac ggcaacgttg 58680 ccgtggcggg tctgcatgaa agtactactg ctgcagacgt gaactatccg cacgagcgag 58740 tacgggctga ctctggcttg ttggatgggg tgtcagaaat aggctcgggt tcagtgccgc 58800 agcggctatg ggccaaaccg gcgatcactg tgattggtat cgacaccaca tccgttgccg 58860 cagcctcgaa catgctgatc ccgcgggccc gggccaagat cagcatgcgg atcgcgccgg 58920 gcggtgacgc tgcggtgcac ctggatgcgt tgaccgcgca tctgcagcgg tatgctccgt 58980 ggggtgccca agtcagcgtt atccgcggcg aggtcagcca accgtacgcc atcgaggcca 59040 gcggcggagt ttatgacacc gcgcggacag cgttccggca ggcgtggggt gctgatccga 59100 ccgatatggg gatgggtggc tcgatcccgt tcatcgccga gttcgcctcc gcgtttccgc 59160 aagcgaagat cctggtcacc ggtgtcggag accctgcaac gcaggctcac ggcgttaacg 59220 agagcgtgca tttgggtgtg ttagaacgcg cggcggtcgc tgaagcgctg ttgttggcca 59280 acttggcctg agtggcgtca aaaatcgtgc ggttcccggg ctctgctgtc ttgtgtctgt 59340 ggcggtgagt tgttcggttg gtttcatagg tggtgggtga aatggctgtt tttgcgtttt 59400 atgactggcc gatatgttcg gtagtcgtgg ggggcagccc ggaatcctgt tgacgtgttt 59460 tgctgtgttg cggggttttt gttgatgggt ggctgactgc ctgctttcga tgaggcttcg 59520 tgtgctttgc cgcagtggac acgattagcg cggcgcacgt aagcatgtcg gtggtggatg 59580 ctgcttggtc tacatgttga tgatgccagg ggctgggcac ctgggctgtg ctgaaggcga 59640 tatcgatgca ggcgtgagtg tgaggatagt tgttagcgcc gcggggtagg ggcgttttag 59700 tgtgcatgtc atggccttga ggtgtcggcg tggtcaatgt ggccgcacct gaacaggcac 59760 gtccccgtgc acggtataac tattcgcacc tgatgttatc ccttgcacca tttctgccgc 59820 tggtatcggt gtcggcggct tgttgaccgg ccctcagcca gcaagcaggc atgccgccgg 59880 gtgcagcagt atcgtgttag tgaacagtgc atcgatgatc cggccgtcgg cggcacatac 59940 ggcaaccttc tagcgcagat caaccaccca caccccacca gcccaccaca acaccaccac 60000 ccaaggcctc aatcacccca acaatgcccc gtccgatgct gactcgcaca ggtcgctgcg 60060 gtgctgtggc ccgtgtgtcg aactcattgg cgtggtcggc aaccggcttg gacgccacgc 60120 gttgcttgat ccggtgcgcc gctggcgcaa aatggatact ggtgtagtgg ctacgcaatt 60180 cgtgtggtga ttaaacaact aaacgaatga tgcgtctgtg tcccagtgcg ccgtggaatt 60240 cccactaagt tgcggtcttc agcgacgctg ataaaaatgc ggatttcatc gcttttacat 60300 agataggtaa ttgatttgtg gactatcggc ttactcggga acagaaccgt aaattgggtt 60360 ccgtgcttaa gtagattcac ctgtatgaaa cttaccccat catctcacca tcgttgcaga 60420 tcttgaagtg ccaactgtct acctgggagt tggcaagagc agaaatcgga ggaatgccga 60480 atagagtagt gtaggagggt actctaaatt gtcctggccg actacattag cgtcagctcc 60540 gatgcgcggt ccagcggcat gtccgcgacg tcttgatcgg agtttaacga catctgtgta 60600 tcttacggaa agacgatccg gtggcaggga tcttaatcgg aacaaagccg gttaaccacc 60660 tcgttgtcgt gaagtaagct aaattgcggc gagtatcgct tggggtgatc gtgtaatacg 60720 tttcggctcc ggtagttttc tgttcagcca cggcggagat cgtgaacact ccgccgcaga 60780 attgtgtgtt cgtcgataag caagtagatg cgaacgcaac tatttgctgc tcgtccataa 60840 actgcacgcc catgatttcg cagtgcgccg aggtgtagtc gagtgacaga gggaattcgg 60900 gaagggctct ctcggtaacc tcgaagaatt tggcccactc gccttatcgc ggggggatct 60960 atggtgcgga tggatgtgtg ctgacgctgc tcggatgcag taaccgtgat agctgcccac 61020 ctttgccagc tggaatggcg ctccgtctct aaaccatagg gcgtctctaa accatagggc 61080 gatgtacata atcttaacat catgtgaatt tctgcgaacg ctacgccgat gaccatagcg 61140 tagcaatgga gatggtcagt cttcaaagag gcaggtgagg tgatcggcgt gcggaatgat 61200 cgagaactgg aagcaagccc actgcagccg gtttggggta gccgacaggt gatttcgcca 61260 ttcgcttgaa tcatttagct agtcatgtct aattgggaca aactggagat cgctgggatt 61320 gctgatcatc cgccacatga agtagttggt ggcagtatgc tcgaaccaac tgcggtaggt 61380 atcatggcaa cccaggtgtg cattgattga cgtgcgtaat ggtacggata tcgtatatcg 61440 tagtgaactg gcatgtccca ggaagaaata agcatccgtg actttctcac agaccgcggg 61500 cggcatatgg gtgatagtta cgaaggtgta tgggcgtgta tatagagctg gctgggacgg 61560 tgttcaccag tgcttggttg gctttaccga tcgttacggg ggacggttgt caggacacga 61620 gcgagtccag ttgtggcatg tattcctgaa gtggaacaac cttcacttcc ccctactgtg 61680 atcacttttc tccaagtcgc tcagcgattg catttcgccc gacggccgct acgtcatcgc 61740 aacttcaatg gttgctagcg gtgtgcacag aaagcaggtt ttgaactgcg atctttgcct 61800 aacacaattg tcgtgataac gtctttatca cgccgacggt cctgtcgata gcaattgagg 61860 cagagttcgg tgccagcggc tagttgataa caaatatgga tcgtgatcgc gtggtaggta 61920 ctatatcctc ttacctgttt agttgtttag tggtcgtgcg caaaaagcga aacccgatca 61980 gtcggtgcag ggctttcgta ccatcgctgt atgtgctggt ttctccagct agtgaccttc 62040 gttagctatg actgaactta ggcgatgtag tggtggttgg attcgccgtt tctgcagcat 62100 ttactttatc ctggtctcac ctccttgcgg cttgcggtgc cacaacccgc gcggatcagt 62160 agaatcgtcg ctaacggcgt cgatccggcc atcaccggtt agccttcgga agaatagcgc 62220 tacgtcctag tagaagccca gtaaaaccga acgggtgggc ccgtcacagc ctcgaatgag 62280 tggccgtgcg ttcgcgtgcg gcaagcgggg tggtaccgcg gcgctcgcgc acctagcgcg 62340 tcgtcgtccc cgtgtctact tgtgttaagt ggcccaggag acgtatgact aacagcgcct 62400 acccgcgcac tgatctgggc gccgaccagc gcggcgggtc cccaaatttt cctgcgctgg 62460 aagcccaggt cctcgattat tggtccaacg acgatacttt tcgggccagc attgcccgtt 62520 gtgacgacgc ccccgagtac gtgttctatg acggacctcc cttcgctaat ggcctgccac 62580 attatgggca tctgctcacc ggctatgtga aggacatcgt tccgcgttac cgcaccatgt 62640 gtggctataa agtagagcgc cgctttggtt gggacacgca cgggctgcct gctgaactcg 62700 aagtcgagcg gcagctgggt atcaccgaca aatcccagat cgacgccatg ggaattgccg 62760 cgttcaacga agcatgtcgc aaatcggtgt tgcgctacac ggaagaatgg caggcgtatg 62820 taacccgcca ggcacgctgg gtcgacttcg ataacgatta caagacactc gatctgtctt 62880 acatggagtc tgtgatctgg gcgtttaaac agctgtggga caagggtttg gcttacgaga 62940 gctatcgggt gttgccgtac tgctggcgcg acgaaacccc gctatccaac cacgaactgc 63000 ggatggacga cgacgtctat caaagccgcc aggatccggc ggtcacgctg ggcttcaagg 63060 tgctgggggg tgacgatgag gacctagttg gtgcttatct tttggtgtgg acgacgacgc 63120 cctggacttt accgtcgaac ctggccgttg ccgtccatcc ggatgtaacc tatgtcgatg 63180 tcagggcagg cgatcgccgt ttcgttttgg cacaggcgcg tctgaccgcc tatgctcgag 63240 agctaggcga cgaacctgag gtgcttgcca cctatcgtgg cgccgatctg ctgggcaggc 63300 actatctgcc gccgttccag tatttctacg agtctgctag aaatgcattt caggtgctcc 63360 caggagactt cgtgactact gatgacggca ctggtatcgt ccatatcgcg cctgcctacg 63420 gcgaagatga tatggcgacc gccgataagg ttggcatcgt tccggtcacg ccggttgact 63480 ctaacggttg ttttgacgcc accgtgcccg attaccaggg gcaacacgtc tttgaggcca 63540 acgcccagat catccgcgat ctgaagaacc agagtggctc ggcggcggtg aacggcgcgg 63600 tgttgcttcg tcacgaaacc tatgagcacc catacccgca ttgctggcga tgtcgcaatc 63660 cgctgatcta ccgtgcggtg tcgtcatggt ttgtcgctgt gacggaattc cgggaccgca 63720 tggtggaact gaaccaacag atcacctggt atcctgagca cgtcaaggac ggtcagtttg 63780 gtaagtggtt gcagggtgcc cgcgattggt ctatctcacg aaaccgctac tggggcaccc 63840 caatcccagt gtggaaatcg gatgatcccg attacccaag aatcgatgta tacggcagct 63900 tggatgagct ggagcgcgat ttcggggtgc gtcccacgaa tctacatcgc ccctacatcg 63960 acgagctcac ccgacccaac cctgacgatc ccaccggcct tagcaccatg cgacggatcc 64020 cggatgtttt tgatgtgtgg ttcgactcgg gttctatgcc atatgctcag gtgcactacc 64080 cgtttgaaaa cgatgactgg ttcgacgggt tcgattccgc tgattctgac aagcaggtcg 64140 acgcgcacta tcctggcgat ttcatcgtcg agtacatcgg tcaggcccgc ggttggttct 64200 acacgctaca tgtgctggcc actgcactct ttgatcgtcc ggcattcaaa acctgtatag 64260 cgcatggggt tgtgctgggg tctaacggtc agaagatgag caagtcgttg cgcaactacc 64320 cagacgttac tgagatattt gaccgcgacg gttccgatgc catgcggtgg tttttgatgg 64380 cctcgccgat cctgcgtggc ggcaacctca tcataactga acccggaatc cgcgaaggca 64440 tgcggcaggt gctgctgccg ttgtggaacg cttacagttt tttggccctt tacgcaccca 64500 aaatcggtac ctggcatacg gatgtgtcgc atgtgttgga ccgttatatt ctggcgaagc 64560 tggcggtact gcgtgatgat ctcagtcagg cgatggaggt ctgtgatatc tctggggcct 64620 gcgaacagct tcgccaattc accgagccgc taacgaattg gtatttgcga cggtcgcgtg 64680 cgcggttctg ggacgaagat gttgatgcta tcgataccct gcacaccgtg ctggaagtga 64740 ccgccaggtt ggctgcacca cttctcccgt tgatcaccga gattatttgg cgcagtgtca 64800 ctggtgggcg ttcggtacac ctgaccgatt ggccgcaagc caaccagcta cccgccgacc 64860 ctgacctggt tgctgtgatg gatcaggtcc gacaagtgtg ttccgcagcg tcatcgctgc 64920 gcaaggctaa gaagcttcgg gtacgccttc ctctaccgaa actcgttgta gcagtgtata 64980 attcacagag actaaagccc tacattgact taatcggcga tgagcttaac gtcaagcaga 65040 tagaactgac cgatgctatt gacacctacg gccgatttga gttcaccgtc aacgctcgag 65100 tggccgggcc gcgattggga agggatgtgc aggctgccat caaggtggta aaggcgggag 65160 aaggggtcgc caacccggat ggcaccctga ccgccgggcc cgttgtgctg caacctgacg 65220 agtacagttc gcggttggtg gccgctaacc cggaatttac cgcggagctg cccgacgggt 65280 ccggtcttgt tgtgttggac gatacggtga ctcccgaact ggaggccgag ggctgggcca 65340 aggatcggat ccgcgaacta caggagttgc gtaagttgat cgggctggat gtttccgatc 65400 gtatccgggt gttgatgtcg gtgccggccg agcgggctga ctgggcgcgc gtccatcgcg 65460 acttcatcgc tagggaaatc ctggccacca gcttcgagtt tggcgagccg gctgattcgg 65520 tggctatcgg agatggcgtc cgagtcagcc ttttaaaggt ctaagtcgag atcaacgttt 65580 tgccgagcaa gtttgagaac agccttgcaa aacgtcgatc tcgacgcgag aaaatcagat 65640 gtaatcgcgt gccagcgctg cgtgtcgtgt cggacgtcga catcatgaaa tcccgctatg 65700 tgcaatcgat ccggcggctc tttcggcgag acatgattgc agatgttgca gcagttcagg 65760 atatggcaga gtagagaagt caggctgttg ttaccggcga agacgccgcc ggagcgaagc 65820 acccggaagg tgtctgcgaa cagccgagct tgctgctttg cggtgtggga cgtgatgcag 65880 catgtgtgaa cgacaccacc tcgctgaact cgtcgtccgg caatccggta tcggtgccgt 65940 ttgcgttgat gatgtttgcc cggttgccgt agaggtcctg cagtctttgg gccatcggca 66000 gatcgatctc gacggcagtg atttttggtg tcttgtctac cagcacccgc aaaaatgcgc 66060 cataccccga cctgatcctc gaggaggtta tcgccgaact ccatgccggc gagcacccaa 66120 ggcaacagcc ggccttcgat ttccttggcc cagtggtccg aaattgcagc acaacctatg 66180 gcagaggttc atgggcatac caaaggacgt agaccaatca cctatggccc ccaaatgcta 66240 ctactaccgg gtatgcggta ccattaaaaa aaaaccgttc ttcgtttcca tagaacaact 66300 taaccgaccg accctgctag ggcggccgat gctagtgggt ggtcgctgga gcgaattatg 66360 gtaatgcaag tgttcaatgt tcgctcggcc aatgcccgat gcaccagctc cgctcgttgg 66420 tcgccgtggc cgcggtggtg ttgccgtcgc gtggtgtgat gtatgtggta gccagtcgtt 66480 gggtcatcgg cgtgctgcgc agtattttgt gtctggtcgg gcaactgtgc gtttgacgag 66540 gcgttcgcct agctgcctcc aacttgtcgg ggtgtcagcc tccgatgtcg aagtgctctt 66600 tgcggccacg ggtgtgagac gagactggct tgatcgcctt ggtcggtgcc ggatcgggaa 66660 agtcgattgc caagattatc tctggtccgg taaaaccgac ggcattaggg ttagtttgtc 66720 gcgtagatga gcagcgattg tttgggggga gttgcctgtg cgtcgactgt ggggcatcag 66780 cccggtcgca gaagattaag ctgaatcgac ttagcatcga gacgatcggg cagttcgctg 66840 cgctgactga ctccgaagcg gctaacattc tgggtgcgac aattgcgcct acgctgtacc 66900 ggctagctcg tggcatcaac gaccgactgg tcaccgagcg tgccgaagca aagcagatca 66960 gctctgagtc cacctttgtg atcaatctga ccagcctgga gcagttatgt gaggcgttcg 67020 agccgatcgc ctcacatgtg tacatgacta ctgcgcgaca gccgcggcgc gcattatcgt 67080 cacggtgaag cgcaagaaat cagacatgag cacactgatg cggttggcga tgtcactcta 67140 acatgacgac cgaaaccagt gcgttaattg cgatggctcg cttgctgttg ctatatccac 67200 gtccgctcgg gactactctg cctttctcag tgtggggttt tcgggattga acggtgtgcg 67260 tcagggaggt ctgttatcgg acgtgagatt gtcggctcag cttttcggag gctgtgatta 67320 ttccgtttgg catccctgcc ggccagcagg ccatcctgtg cacaaccgtg tggcttgata 67380 gattggcaaa acgacatcaa gcatcgtgac cttgggcacg gctgaattca ggacgtgggc 67440 tacgtcgtgg taactgtgcg ggtgtgagac ctgcggctcg ggtccggggc cagcccagac 67500 attcaccgtc gacacctgcg atgtcgttaa agtcaacccg cttgacagtc tcgactggtc 67560 ggactatctc gactggtcgg actatatagt caagtggtgg gtcgaggatt cggtgggtac 67620 gttagcccca gcgttcgatg acgtcagcga tcggtaggtt tgcggccagc gcagccatca 67680 acagcacccg gacctgcgag ggtcgtagcc atggcaccag caccgcgccg gcttctacca 67740 ggtcgtggcc aggaccgtag cctgcgctga catggccttc gggcacgcgg gtggacaccg 67800 cgatcacgat cccattgtgg caatggcggc gtaccccgtc gactaccgcg gccccggcat 67860 tgcccgagcc cagtgcctcc aggacgatgc cacgcgctcc ggtggacaca taagcgtcca 67920 acgccaccga atcactgccc aagtatgccg cgacaatatc gactcgcggt gcatcggcgg 67980 cgcacaggtc cccgagatac gggcgggtct tggctgctgt cagcgcaaaa ccgctggagc 68040 tggtgccgag caactcgccg gcgaagccgc tcagatcctg cgtagctgcc ttgcgtaggc 68100 ctaacggttg taatacccgg ccggcgaaag acaccagtac gcccacgccg cgagcggccg 68160 gactagccgc caccgcaagt gcttcgcgca gattggtcgg accgtctgca ttgggagcgt 68220 cggcgctgcg catggcgccg gtcaagacta ctgggacgtt ccccgcgtag gtgaggtcca 68280 gccacagtgc ggtctcttcc atggtgtcgg tcccgtgggt gacgaccaca cccctggcgc 68340 cgtttctggt cgctgtgtgc actgcagcgc gaatccgatc ccaatcggtc ggtatcagct 68400 gtgagctgtc gacagtcatc aggtccacca cgtcgacatc gacggccacg tgtgcggtca 68460 gttccgttcc gctgtaggcg gggcggcgca ccccatcgtg gtcggtactg gtcgatatgg 68520 tacctccagt ggcgatgacg gtgaggcggc tcatggtggg atcatcctgc acgattggtc 68580 ggtccgtatc gatcgcgggg gtcggtagga cagtattacc cttgggggat gatgggtaga 68640 gtgcctgacg gaccaacagg attggctgcg ttggtgcctt cagttgagga agctcaagct 68700 atgctgcctc cgcggcggct gcgtctgctg ttgtcgatcg cggcggttgt gctgacgctg 68760 gacattgtca cgaaggtgct cgccgtcaag tttttgcttc ctgggaagtc ggtgtcgatc 68820 atcggtgaca cggtgacctg gactttggtg cgaaattcgg gagcagcctt ctcgatggcg 68880 accggataca cttgggtgtt gacgctgatc gcgacgggtg tggtgattgg gatcttctgg 68940 atggggcggc ggctggtgtc gtcttggtgg gcgttgggtc ttggtatgat ccttggtggt 69000 gcgatgggta acttggtcga tcgcttcttc cgcgcgcccg cgccgcttcg gggacatgtc 69060 gtcgattttt tgtcgatcgg ctggtggcca gtgttcaatg ttgccgatcc atcggtggtg 69120 gtcggtgcca tcctgctggt cgtcctgtca atctttggct ttgacttcga cactgtaggt 69180 cggcgtaaag ccgagttcga cattgcaggt cagcggaagg ctgaacagcg ttgatggccg 69240 gaagcgacga tgaagagggc agaaatgcgg tggggaggtg ccccccacag gtgggtgtgg 69300 gcgccccact ttgggggcgt gcctcaattg tttgcgggga agagtagcgc ttgtgacgga 69360 ccgttctatg cccataccgg agggactcgc gggcatgcgt gttgatgctg ggctggcgcg 69420 cctgctgggc ctgtctcgaa ctgccgtagc tgctctcgcc gaagatggcg gtgtcgagtt 69480 ggatggcgtg caggcgggaa agtccgatcg gctgacgtcg ggtgcctggc tgcaggtacg 69540 cttgtgcgag gcaccggcgc cgttggagaa cactccggtc gacatcgagg acatgacgat 69600 cctgtattcc gacgacgata tcgtcgcagt tgacaagccg gcagcggtgg cggcgcatgc 69660 atcagtaggc tgggccgggc cgacggtgct cggtggcctg gctgctgccg gctaccggat 69720 caccacatcg ggtgtgcctg agcgccaagg cattgtgcat cgcctcgacg tcggcacctc 69780 gggtgtgatg ttggtggcga tctccgagcg cgcctacaca gtgctcaagc gggcgttcaa 69840 atgccggacg gtcgacaagc gctaccatgc gctggtgcag ggccacccgg acccgtccag 69900 cggaacgatc gacgcgccga ttggccgaca ccgtggccac acctggaagt tcgcagtcac 69960 caaagacggt cggcacagta tcacccacta cgataccctg gaagccttcg tcgccgcgag 70020 cctgctagac gttcatctgg aaaccgggcg cacccaccag atccgagcgc attttgccga 70080 attgcatcgg ccatgctgcg gcgacctcgt ttatggggcc gacccgaagc tggcgaaaag 70140 acttggtcta gaacgtcaat ggctgcacgc tcggtcgttg tcattcgccc atccggccga 70200 cggcaggcgg gtcgagatcg ttagctccta cccacccgat ctgcagcacg cactggatgt 70260 gctgcgcgct gaaagctgac tggcaccaac gttcagtcag gtttgcaggt atcgacgagg 70320 actcgcgtca agttcgcgac gaacggcccg tcggcctcaa tgcgttcatg aagttcccac 70380 agccggttgc gatagcggtc cacagttaaa gtcaggcacc gtctaaataa tcttacggag 70440 taagtagata ctggcgccga tgtcgaaact cgactcgtag ccgcttcatg cgtagattca 70500 cgctactgta ggccaaccgg cttgtgtttg cgtacttacg aggctggggt gatactcggc 70560 ccatttttcg ggttgcggtc cgctgaagta ctcgattagt tcgaacatcg ttgcgggtct 70620 gatttgctac gcaaagtagg tgccgcccgg tcggagcatc tgaacgatct cggtccacca 70680 cacggagatc ggatgacggg aggtcatcag gtcaaacgct ccttaggtgt gggggcggcg 70740 tcgcgccaga ctaaaacctc gacgctgccg gtgtgcagtg ctaacgtggc ctatacgcta 70800 gccaaatgtt gattcaaagc ccgttgatag cctcaggacg gtctttgctc cgtcgcatgg 70860 ggcccttgta cagggtacag caaagaaaat tcccagctct cgacggatac cgaatcagct 70920 tttgccgcca gctcttttcg catgtgcatc gcatggcaga cattctcagc taaatggacc 70980 ggaccgttgc cggtatgccc agatatcgat ttagcatcgc ctcgatgcgt acatttgttg 71040 gccggggatg gcgaacctgg aactcgttga tcgggcgttg cggcgtcgta tagactaact 71100 tgttgccgtt gaaatcaagc ctgacctcgc cttggtactc tcaatattca atgccttggt 71160 gtctaccggg cgtcactgcc ggatggtggg ataaacagga tcggctggtt gtcgttctag 71220 tcgagcacgg cggtaggcta gttgaactgg ttgtagaact gtgcggtcaa cgactcggat 71280 ccgtgaaggg cagtggcacg tgatcaccgt tggtaccgtg gtagctgggt tagcgattgc 71340 tagctggacc agctggatct gataggcctc taccacgcag gtggatatat cggcgttttg 71400 tgcggagccc tatcgcggac cgtggaccaa cggttttgtg gctggttgtc agggtggttt 71460 ggtccgcgtc aggacgggcc ggtgcctggc taataggcgg tctgcagccg gtggtcgagc 71520 ccggtcaggc ctgggctgta gtggtttcgc ccgatactac gtcgtcacta cgtcgtcggg 71580 gagggcagtg gatccgatgc ccctgagtgt ctccggcaca gagtcttagc ggggattccg 71640 acggctgtga gtgcggtcgc tcaagtgtct tgccgcgaga gtggaagtga tactatggtg 71700 actcctcgcc ctgtatacac ctgattgcat cgacgtatcg ttctagaact caggcctgcc 71760 gagagttgcc gcgataaatt cagcctgttt atcccttacg atggctcatt aattcgttcc 71820 ggtgaaaacg tgggcacaga aatcctaaac gacaatttca tcgtctcgta tccgccaatc 71880 ctatcggaga ttctgacggg ctcgcgtttg tggaattgtg acgaaattcc cataggggca 71940 gccgggaact gcgatgttct gtgtacgtta gcatctgatc atgtccacat tatgtattgt 72000 ttaacaatct gttttcccgt tatcagccat aaattttgtc gtctgtgcgg cgcctgggct 72060 gggtaacatg acgacgatct tcatcgattc attcagtgat gttctcgggt gggcatggtt 72120 acccggctcg catcacccac gtcgtccagt gaggtggccc tggtcggcga ccggggcagc 72180 tgcggtccga gtgcgaacat cgctaggagc gacgatcgat gaattttggc gaccttacga 72240 acctcgccga aaagccgttg gcggcaatgt cccatgtcgt caacacctct aattccgcgg 72300 ggcgataccc ctgttctatc tgcggaacct gcttgatatg gttcagcgcc gcaaatgcgg 72360 cgaagcggtc ggtcgcaaga cctgtcctca tcaccggaag gttgtcggtt gtacggtgcg 72420 gtagcggcca aaatcgcagc cgcaggtggc acggtggtgc tggtcgcgtg caccctggag 72480 aacctcgaaa aagtagcctc ggagagtcga gttagtcatc gcggtgctgt ccatgtgtaa 72540 ccgagcgact tttccgacgt agatgctatc gccgctatgg ccgaccagct gctcgctgat 72600 ctaggcggcg tcgacatgct gatcaataat gctgggcact cgattcggtg gtcgttgacg 72660 ctgtcttacg atcggattca tggctgtcag cgcacgatgc agttagaatt gcctgaggac 72720 ggttcaaatt catccctggg atgcgggaac ctggtattca ggcagattgt caacgttttg 72780 tcggttgtgg tatgctgcgc ttgggtgcct gcatcgctag caacgctgtg ctgggcagcc 72840 tgtgcggtgt gatggaagcc gagataatga acaacaacgt tcgattcacc gctgtacaca 72900 tggcgttggt gcgtacgctg atgatcagac cgatcaacct gtaggattaa gttcccgatg 72960 ctaacttgag agcaggtaac ctacgtgatc ctgcgccggc ctcggtgggt ccgctcaacg 73020 ttcgcccgtt gccgatgcgg ttaaccttgc gggtgatgga ccggttacgc aacggcgtgt 73080 ttggtacgtt cacctactct gccgccaagg actgctaatc tgccgttagc acagcgaagg 73140 tcgaggagtt cgataagcga agcgaaacat tggtccaagt gagtcgtggg gtgcattttg 73200 gtgacgtcat caactttccg gagtcgaaca atgggacaac cttcgtcatc accgatccct 73260 cctgagacat cagggtcgaa ctcccttgtg gcttggcccg cagcggtttt ccactgctgt 73320 tcatcggtgt ggtgatgtag actgcctcgg agagtttgcc aacgaagtag accagggata 73380 ctgctcccgc agttgaggtc atgcctctag acctcggcta ccccatgatc gcgcaaagtt 73440 ggcggaccgg cttcgctact aaccgatcgg cggtttgtgc atacagtgcc cgcctttggc 73500 accagcgggc tattgtgcac gtttccactt gaacgcgaga gcggagaggt gactctcaac 73560 tcgatcgtgt tgatggaact gacgcatgtg gtgttgccgg gcatggttga gcgctgctcc 73620 ggtgcggtca tgaacatcgc atcgatggtc ggttgccagt tgattcccca catggtggtt 73680 tatgcagcca ccaaggccgt tgtcccagat attcgcgtag actattcaca aggagttgca 73740 cggtataatg ggcatcggtc aaggttttgt gctcggctct ggttccgacc gaatgggccg 73800 agatcgccaa taccgaacga ttcagtattc tccgttgtcc aggtgcaacc gcagaacttt 73860 acatgaagtc gtgagcggcg ggtgctggac ggtcagagca gagtggcgct caaattgtca 73920 gcactagcgg cagatacgta tcgcgttgcc tgcgatccgt atcggtaacc gattgcgtgt 73980 cgggtaggtc gctaactggc gtggattcgg ttccgtgcga tttcgcgtgg gctatttagg 74040 ccaggatgat tagcgtggct tgtgcttggt gttatgtgtc ggcgtcgccg cggctaggct 74100 caggtggtgg ctgttaagtt gacatgaccg ccgatgtgtc gatgactcct caggactcct 74160 gggaccatat ttcggatctg tcggagctgg gcgattggct tgtcatgaat gaaggggtgg 74220 cgtagcgagc ttcgttagga gctgactgta ggcacccaaa tgtgagcgtg tggggcgcat 74280 gccaagggca tgcgcaaccg ggtgatctgg acaatcacga tatgggacct gcccaataag 74340 ttggcattct cagtatcctg gaaagggcgg caccaagtac ggcgtcacag ttcactgtgc 74400 ggtacaaaaa cgactgatcc acgtttggct tgcaccttga gtgcgccggt cctgcgctgt 74460 tcggttcgct agagtccgcg gcggcacgcg tggtcaaagg gtacgtagag aaatcgctta 74520 agcagtttgt gaagttgtat gcctgacgag gatcgaacac atgcggcgac atgccgagat 74580 accgtcagtc gtcggtcata gactggcgtc tctatgaacc agtcttcctt cgttcacctg 74640 cataaccaca ccgagtactc gatgctggac ggtgctgcga agatcacgcc catgttcgcc 74700 gaggtcgaac ggctacagat gcccgcggtt ggcatgaccg atcacggaaa catgttcggt 74760 gcgagcgagt tttacaatac ggccatcaaa gccggaatca agccgattat cggtgtggaa 74820 gcttacatcg ctcctggatc ccgttttgac acccggcgca ttacctgggg tgaccccagc 74880 cagaaggctg acgatgtctc ggcgggtggt gcttacacgc acttgacgat ggtggcagag 74940 aatgcggcag gtctgcgcaa cctgttcaag ttgtcttcgc tggcttcgtt cgaggggcag 75000 ttgagcaagt ggtcgcgaat ggatgccgag cttatcggtg aatatgccga gggtatcatt 75060 gtaactactg gctgcccctc cggtgaggtg cagacccggc ttcgcctcgg gcacgaccgg 75120 gaggcgttgg aatcggccgc caagtggcgc gagatcgttg gccccgataa ctactttctc 75180 gagctgatgg accacggctt gtctatcgag caacgtgtcc gcgaaggact gcttaatatc 75240 ggccgcaagc tcaacattcc tccactggcc accaacgact gccactatgt cacccgcgac 75300 gctgtgcaca accacgaggc gttgttgtgt gtacagaccg gcaagacctt gtcggatccg 75360 aaccggttca agttccacgg tgacggctat tatctcaagt cggctgccga gatgcgccag 75420 ctttgggacg acgaagttcc tggggcctgc gactccacgc tgctgatcgc cgagcgggtg 75480 cagtcctacg ccgatgtgtg ggaaccgcgc aatcggatgc ctgtcttccc tgttcccgtg 75540 ggacacgacc aggcgtcttg gctacgtcac gaggtggatg ccggcctcaa gcgccgattc 75600 cccgatggcc cacccaacgg atatgtcgaa cgggcggcct acgagatcga cgtcatttgt 75660 gacaagggtt ttcctgccta ctttctgatc gttgcagacc tggtcaacca tgcccggtct 75720 gtcgggatcc gcgtgggccc gggccgcggt tcggcagccg ggtcgcttgc cgcctatgcc 75780 ctggggatca ctgacatcga cccgataccg cacggtctgc tgttcgagcg gtttctcaac 75840 ccggaacgca cctcgatgcc tgacattgat atcgacttcg acgaccgtcg ccgcggtgag 75900 atggtgcgct acgccgccga caagtggggg catgacagag tcgctcaggt catcactttc 75960 ggtaccatta aaaccaaagc ggcgctgaag gattctgcgc ggatccacta cgggcaacct 76020 ggttttgcta tggccgaccg tatcaccaag gcattaccgc cggccataat ggccaaagac 76080 atcccgttgt cgggaatcac cgatccggcc cacgaacggt tcaaggaagc cgccgaggtc 76140 cgcagcctga tcgaaactga ttcggacgtg cgcatcatct accagactgc tcgcgggctg 76200 gagggtctga tccgcaacgc cggcgtgcac gcatgcgcgg tgatcctgag tagtgagccg 76260 ttgaccgagg cgatcccgct gtggaagcga ccgcaggacg gggccatcat caccggctgg 76320 gactacccag catgcgaggc catcggtctg ttgaagatgg acttcctggg tctacgtaac 76380 ctgacgatca tcggcgatgc gatcgaaaac attaagacca acaggggaat tgatctcgat 76440 ctggaatccg tgccactgga cgaccaggcc acctacgagc tgcttggccg cggtgacacc 76500 ctgggtgtgt ttcagctcga cggtgggccc atgcgcgacc tactgcgtcg catgcaaccg 76560 accggattcg aagacatcgt cgcggtacta gcgttgtatc ggcccggacc gatgggcatg 76620 aacgcgcaca acgactacgc cgaccgcaag aacaaccggc aggtaatcaa acccattcat 76680 cccgaactcg aggaaccgct gcgtgagatc ctcgctgaaa cctatggact catcgtctac 76740 caagagcaga tcatgcgaat cgcgcagaag gtggccggtt actctttggc ccgagcggac 76800 attctgcgta aggcgatggg aaaaaagaag cgcgaggtgc tggagaagga gttcgagggt 76860 ttttcggaag gtatgcaggc caacggattc tcggtccacg ccatcaaggc gttgtgggac 76920 atcatcttac ctttcgccga ctacgcattc aacaagtctc acgccgctgg ctatggccta 76980 atatcctatt ggaccgccta tctcaaggcc aactttgctg gtgaatacat ggcgggcctg 77040 ttgacttcgg tcggcgacga taaagacaag gcagctgtct atctggccga ctgccgcaag 77100 tttggcatca cggtgctgcc gccggacgtc aacgagtccg tcctggactt cgcctcggtg 77160 ggtgctgaca tccgctacgg gttgggcgcg gtgcgcaatg tcggtgccaa cgtggtaggt 77220 tcgttgatca agactcgcaa tgccaagggc aaatttgctg acttctcgga ctatctgaac 77280 aagatcgaca ttacgtcctg caacaagaaa gtcactgaat cgctgatcaa ggcaggagcc 77340 ttcgattcgt tagggcattc tcgcaaaggt cttttcctgg tccacgctga cgctgtggat 77400 tcggtgctag gcaccaagaa agcggaagcg atcgggcagt tcgatctgtt cggcggaact 77460 gatggcggca ctgacgcggt atttaccatc aaagttcctg acgacgaatg ggaggataaa 77520 cacaagctgg ctctggaacg ggagatgctg ggcttgtatg tgtccgggca tccgctcaac 77580 ggagtggcac acctgttggc tgctcaggta gacaccgcca ttccgacgat tctcgacggt 77640 ggtgtctcca atgatactca ggtgcgggtg ggtggcattc tggccgcggt gaaccggcgc 77700 gtcaacaaaa acggaattcc ttgggcgtca gcgcaattag atgatttgac tggagggatc 77760 gaggtgatgt tcttcccgca cacatattcc agctacggcg ccgacatcat cgatgatgct 77820 gttgtgttgg ttaatgccaa ggtggtggtt cgtgatgacc ggattgcgct gatcgctaat 77880 caacttgttg ttcctgactt ttccaacgtg caagaggacc ggccgctggc ggttagtttg 77940 ctgactcggc agtgcacgtt cgacaaggta aatgcactca agcaagtgct ggcgcgccac 78000 cccggcacat cgcaagtcca tttgcggctt atcagcgggg accgaatcac tacgcttgaa 78060 ctagaccagt cgctgcgggt gacatcgtcg ccggcgttga tgggagacct taaggcgctg 78120 ctcggtcccg ggtgtttggg tgattagcaa accgcagtac tggtgctgtg ttgtgggtgt 78180 tttgtcggtg gtgggtgaaa tggctgtttt tgcgttttat gactggccga tatgttcggt 78240 agtcgtgggg ggcagcccgg aatcctgttg acgtgttttg ctgtgttgcg gggtttttgt 78300 tggtgggtgg ctgactgcct gctttcgatg aggcttcgtg tgctttgccg cagtggacac 78360 gattagcgcg gcgcacgtaa gcatgtcggt ggtggatgct gcttggtcta catgttgatg 78420 atgccagggg ctgggcacct gggctgtgct gaaggcgata tcgatgcagg cgtgggtgtg 78480 aggatagttg ttagcgccgc ggggtagggg cgttttagtg tgcatgtcat ggccttgagg 78540 tgtcggcgtg gtcaatgtgg ccgcacctga acaggcacgt ccccgtgcac ggtataacta 78600 ttcgcacctg atgttatccc ttgcaccatt tctgccgctg gtatcggtgt cggcggcttg 78660 ttgaccggcc ctcagccagc aagcaggcat gccgccgggt gcagcagtat cgtgttagtg 78720 aacagtgcat cgatgatccg gccgtcggcg gcacatacgg caaccttcta gcgcagatca 78780 accacccaca ccccaccagc ccaccacaac accaccaccc aaacccaaac cagcaaaaaa 78840 taaccaccaa atgaccatca cgacgacacc ttgaagtcta aacggacaag ttactggtta 78900 ctggccgggc gcggcgtctg gcaccagggg catattgcgt cagtaccgcc ggtttctcga 78960 tcgggggcaa tttgccgatg agatcagcgt gacatccggc gtgtcaactt aatcgccgaa 79020 ttggccagaa cccacgatgg tggtttagtc gctggagtag ctgagagatt gctctagtgc 79080 tctagtgact ggaaggcttt gagagcgcct tgagaactaa accgattacg atggcaacgg 79140 ttggcaccac caaggccggc cggagcagca ctggtggtca acacctcgac cagcagtagc 79200 gttacgaacc ctgcgatcac cgcgagcagt ttttgcagcg gccagggcac atccataaaa 79260 agcacctctg aggttttggc cgggccagta acagataagg atactctatg gactattttc 79320 cgggaacccg acgacttcag ggaacggaca gctgacggtc tagggtgctg cttgtccctt 79380 tcatgggagt atgtatgtac ctagcccggt cgactgggtg cgcgagcaag ctgagaggta 79440 catggcttcc tgcggaaccg agggcacgga actgcaagaa aagcccgtag tattgccgac 79500 cactgtattg tcggcgctaa gaccggcaaa cttcgtaaaa ctccgctaat gcgtgttgag 79560 cacaacggcg agtacgcgat cgtcgcctca ggcggaggag cttcgaaaca cctggtctga 79620 tactacaacg tcgtgcagta tccgaaggtc gagctgcggg atggtctcgt cagccgtgat 79680 tatgacgcgc gtgaggtatt tggcgaagag aaggccacct ggtggcagcg cgctgtcgag 79740 gtctggccgg actacgtcaa ctaccagacc aaaactgaac gttagattcc ggtctttgtg 79800 ctgactccgg tgagctgatt gcttgtcgga cgacatggca ccatggacct atgtccgccg 79860 aacctagtag aaaccccagg accccaccgg tgtccgcggt tgacattgac ggtgcggcga 79920 agcggatcgc gccggtggtc acgcctaccc cgttgcaact tagcgatcgg ttgtcggcga 79980 tcactggtgc agcggtgtac ctcaagcgtg aagacctgca gacggtgcgc tcttacaaac 80040 tgcgcggcgc ctacaacctg ttggtgcagc tgaccgacga ggagatcgcc gccggcgttg 80100 tgtgctcttc ggcgggtaac catgcacagg gtgtcgcgta tgcatgtcgg tcactgggtg 80160 tgcacggccg tgtctatgta cctgccaaga cacccaaaca aaagtgggat cggatccgct 80220 accatggcgg ggcattcatc gagctgatcg tcgggagatc gacctacgat ctcgccgctg 80280 ccgcggcggt cgacgacatt gaacgcaccg gcgcgacgtt ggtacctcct tatgacgacg 80340 tccgcgtcat cgctggtcag ggcaccattg ccgtcgagtt gctggagcaa ctcaacaccg 80400 agcctgacct agtggtggtc ccggtgggcg gcggtggctg catcgccggc atgaccactt 80460 acttggccga acgaacggcg aacactgctg tgcttggtgt cgagccggct ggtgccgcgg 80520 ctatgatggc cgcgctggcc gcgggtgagc cggtgacact ggactacgtc gatcagttcg 80580 tggatggcgc tgcggtgaac cgggtgggaa cgttgcctta tgccgcgttg actgccgcag 80640 gtgacatggt gtccatcacc accgtcgacg agggggcggt gtgcactgcg atgctcgacc 80700 tttaccagaa cgagggcatt atagctgagc cggcgggcgc actgtcagta gctgggctgc 80760 tggaaactga cattgaaccc gggtccaccg tggtttgcct gatctcgggc ggcaacaacg 80820 acgtattgcg ctacggtgag gtgttggagc gttcgctgat ccacctaggt ctcaaacact 80880 atttcctggt agacttcccc cagaagcctg gtgccttgcg ccgttttctt gacgaagtgc 80940 ttggacccaa cgacgacatc accttgttcg agtacgtcaa gcgcaacaac cgagagaccg 81000 gcgaggcgct ggtaggtatc cagctggggt ctgctgtcga cttagacgtc ctgctggccc 81060 ggatgcaggg gaccgaaatg cacgtcgaaa ccctacaacc aggttcgccg gcctaccgct 81120 acctgttgct ttagacgaga acgcacgtag ttgtacacgt tttacggcgt atcg |