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EBI DbfetchID AL583920; SV 1; linear; genomic DNA; STD; PRO; 348450 BP. XX AC AL583920; XX DT 20-FEB-2001 (Rel. 66, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 3) XX DE Mycobacterium leprae strain TN complete genome; segment 4/10 XX KW . XX OS Mycobacterium leprae OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium. XX RN [1] RP 1-348450 RX DOI; 10.1038/35059006 RX PUBMED; 11234002. RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., RA Wheeler P.R., Honore N., Ganier T., Churcher C., Harris D., Mungall K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., RA Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., RA Jagels K., Lacroix C., Maclean J., Moule S., Murphy L., Oliver, Quail M.A., RA Rajandream M-A., Rutherford K.M., Rutter S., Seeger K., Simon S., RA Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., RA Whitehead S., Woodward J.R., Barrell B.G.; RT "Massive gene decay in the leprosy bacillus"; RL Nature 409(6823):1007-1011(2001). XX RN [2] RP 1-348450 RA Parkhill J.; RT ; RL Submitted (20-FEB-2001) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium leprae sequencing teams, The RL Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, RL UK Unitie de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du RL Docteur Rouux, 75724, Paris Cedex, France. E-mail: parkhill@sanger.ac.uk XX DR EMBL-CON; AL450380. DR RFAM; RF01118; PK-G12rRNA. DR SILVA-LSU; AL583920. DR SILVA-SSU; AL583920. XX CC Notes: CC CC Details of M. leprae sequencing at the Sanger Centre CC are available from http://www.sanger.ac.uk/Projects/M_leprae/ CC A relational datbase containing the M. leprae sequences is available from CC http://genolist.pasteur.fr/Leproma/ XX FH Key Location/Qualifiers FH FT source 1..348450 FT /organism="Mycobacterium leprae" FT /strain="TN" FT /mol_type="genomic DNA" FT /db_xref="taxon:1769" FT CDS 551..1786 FT /transl_table=11 FT /gene="ML0842" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 44.6 kDa protein Rv1464 or MTV007.11 TR:O53155 FT (EMBL:AL021184) (417 aa) fasta scores: E(): 0, 43.6% id in FT 408 aa and to many other bacterial nifS-homologues, e.g. FT Bacillus subtilis YurW protein yurW TR:O32164 (EMBL:Z99120) FT (406 aa) fasta scores: E(): 0, 46.7% id in 405 aa. FT Previously sequenced as TR:O32975 (EMBL:Z98741). Contains FT Pfam match to entry PF00266 aminotran_5, Aminotransferases FT class-V." FT /note="Similar to ML0117, ML0596 and ML1708" FT /db_xref="GOA:O32975" FT /db_xref="HSSP:1P3W" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:O32975" FT /protein_id="CAC31223.1" FT /translation="MVDVFDIQAVRADFPILQETVNGKPLIWFDNAATTQKPQVVIDRL FT SYFYAHENSNIHRAAHELAARATDAYEEARETARRFIGAAKAQEIIFVRGTTEAINLVA FT YAWGGKHLQPGDEVVITHLEHHANIVPWQLLSSQTGAILKVAPVDDAGNLLMSEFEDLL FT GPRTKLVAATQVSNALGTVTQGEKIVELGHRYGARVLIDGAQSIPHLPINVSELGADFF FT VFSGHKIYGPTGIGVLYGCEDVLTEMPPWQGGGNMIVDVTLERSLYQGPPNKFEAGTGN FT IADAVGLGEALRYVERVGVQRIASHEQALLDYATPRLADIPGVRLVGTATEKASVLSFV FT LAGHEPLEVGKALNAEGIAVRAGHHCAQPVLRRLGLEATVRPSFAFYNTYEEIDVFINV FT VRRIAEGGTNIG" FT misc_feature 653..1738 FT /note="Pfam match to entry PF00266 aminotran_5, FT Aminotransferases class-V, score 23.70, E-value 1.7e-08" FT CDS 1908..2395 FT /pseudo FT /transl_table=11 FT /gene="lppP" FT /gene_synonym="ML0843" FT /product="lipoprotein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lppP (Best blastx score 294)" FT RBS 2549..2555 FT /note="possible RBS" FT CDS 2559..4112 FT /transl_table=11 FT /gene="narK" FT /gene_synonym="ML0844" FT /product="putative nitrite extrusion protein" FT /note="Similar to Mycobacterium tuberculosis putative FT nitrite extrusion protein narK1 or Rv2329c or MTCY3G12.05 FT TR:P71883 (EMBL:Z79702) (515 aa) fasta scores: E(): 0, FT 69.3% id in 488 aa and to Escherichia coli nitrite FT extrusion protein 2 narU SW:NARU_ECOLI (P37758; P77696) FT (462 aa) fasta scores: E(): 0, 36.6% id in 459 aa. There is FT a frameshift near the C-terminus relative to the M. FT tuberculosis homologue. Previously sequenced as TR:O32974 FT (EMBL:Z98741). Contains hydrophobic, probable FT membrane-spanning regions." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:O32974" FT /protein_id="CAC31225.1" FT /translation="MDQLVLLQAEESLYGPGRRSKTVPIDHRHSLKSSFFRLRLRRACR FT ISHWDPEDQAAWEAGNKTIARLNLLWSVLTVHLGYSVWTLWPVMELFMPKDVYGFSAGD FT KFLLATTATLVGACLRVPYSLATALFGGRNWAIFSVMVLLIPTIATMVLLAHPGLPLWP FT YLACAALTGLGGGNFAASMTNANAFYPHRLKGAAFGLAGGAGNLGVSVIQVVGMLVIAS FT VGDRKPYIVCGLYVVLLIIAGIGAMLFMNDIEHHRIGVNTIRPVLFVVVSTRDSWVLAL FT LYLASFGSFIGFSFAFGQVLETNFVAGGQSTAQAALHAAELAFIGPTLAAVARFWGGRL FT ADRLGGSRVTLVVFGAMVFAAGLLGVLGIIEGSRVCPIRGVMMASYFAGFITLFILSGL FT GNGSVYKMIPTIFEACSHSLGINDDECRDWSRVISGVVIGFVAEVGALGGVGIDLALRE FT SYLNTGGVTAAFWIFMLCYAAAGVLTWKMYVCRPLPGNLHDEAANAFAASVGASRTHRG FT " FT CDS complement(4100..4681) FT /transl_table=11 FT /gene="ML0845" FT /product="hypothetical protein" FT /note="Unknown function. Similar to part of some acyl-CoA FT oxidases e.g. Arabidopsis thaliana acyl-CoA oxidase cx2 FT TR:O65201 (EMBL:AF057043) (692 aa) fasta scores: E(): FT 1.5e-06, 35.2% id in 125 aa. Previously sequenced as FT TR:O32973 (EMBL:Z98741) (193 aa) fasta scores: E(): 0, FT 99.5% id in 193 aa." FT /db_xref="GOA:O32973" FT /db_xref="InterPro:IPR013764" FT /db_xref="UniProtKB/TrEMBL:O32973" FT /protein_id="CAC31226.1" FT /translation="MPLRPTNAASERVTKRTATETILQRMVGARQDSEKKGSLFNRGTQ FT GTIFEKCEDCLLSAVARRRQVKSKEMFAFDTFNTVQDHLLHAANEHTDRVVLETFLAGI FT ESCNDPAARKLLDIVCDLYALSVKARHGTSSIDTSPPSALKAIAKGSRPMPSAAALCRD FT VGRRFSESQSSCVTPRCRTSRICPSELQPR" FT CDS complement(4959..5480) FT /pseudo FT /transl_table=11 FT /gene="ML0846" FT /product="ABC transporter (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv1747 (Best blastx score 127)" FT CDS complement(5522..5848) FT /pseudo FT /transl_table=11 FT /gene="ML0847" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2327 (Best blastx score 184)" FT CDS 5906..8080 FT /transl_table=11 FT /gene="ML0848" FT /product="ABC transporter" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT ABC transporter ATP-binding protein Rv2326c or MTCY3G12.08 FT SW:YN26_MYCTU (P71886) (697 aa) fasta scores: E(): 0, 76.9% FT id in 697 aa. Shares similar domains with many ABC-type FT transporters e.g. Streptomyces roseofulvus ATPase component FT of putative ABC transporter frnD TR:O68910 (EMBL:AF058302) FT (524 aa) fasta scores: E(): 8.4e-14, 31.5% id in 495 aa and FT Synechococcus sp. nitrate transport ATP-binding protein FT NrtD nrtD SW:NRTD_SYNP7 (P38046) (274 aa) fasta scores: FT E(): 1.6e-12, 34.8% id in 198 aa. Previously sequenced as FT TR:O32971 (EMBL:Z98741). Contains hydrophobic, possible FT membrane-spanning regions. Contains 2 Pfam matches to entry FT PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 FT ATP/GTP-binding site motif A (P-loop). Contains 2 x PS00211 FT ABC transporters family signature." FT /db_xref="GOA:Q9CCF9" FT /db_xref="HSSP:1US8" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q9CCF9" FT /protein_id="CAC31229.1" FT /translation="MDLCIHRRMALLCQATRRCHRWKTQLGRCAAPDLAPGTGTIGKVT FT AHDPRHLHHRSGSLQPGELAQASVLAALCAVTAIVSVVVPFAAGLALLGTVPMGLLAYR FT YRFRVLMTAMVAAGVIAFLITGLGGFIAVVNSAYIGGLTGVVKRKGQGTLTVIALALFA FT GLAFGAANVVALVVLGRLRHLIFKAMTANVDGIAATLTWMHLPWVAVQLKRYFADGLQH FT WPWMLLGYFVITILVVSLIGWWVLSRVLERIRDIPDVHKLDAPSACNEDAPVGPVPVWL FT DKVRFRYPHAGQDALREVSLDLRVGEHVAVTGANGSGKTTLMLILAGREPTSGTVDRPG FT AVGLGKLGGTAVVLQHPESQVLGTRVADDVVWGLPPGTDVDVNRLLREVGLDAFAERDT FT GSLSGGELQRLALAAALAREPSLLIADEVTSMVDRQGRDALLGVLSGLTKRHPIALVHI FT THYNNEADTADRTINLSDSPDNAGMAETVAPPVSTVAVDHRPHAPVLELVGVGHEYGSG FT TPWAKAALHDISFVVRQGDGVLVYGSNGSGKSTLAWIMAGLMVPTTGACLIDGRPTHEH FT VGAVALSFQAARLQLMRSRVDLEVASAAGFSPRDEDRVAAALGVVGLDPALAKRRIDQL FT SGGQMRRVVLAGLLACSPRALILDEPLAGLDAVSQRGLLRLLEDLRCERGLTVVVTSHD FT FVGLEDVCPRTVHLRNGALESVSTTAGGTS" FT misc_feature 6821..7336 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 112.30, E-value 9e-30" FT misc_feature 6842..6865 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 7109..7153 FT /note="PS00211 ABC transporters family signature" FT misc_feature 7508..8038 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 125.00, E-value 1.4e-33" FT misc_feature 7529..7552 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 7808..7852 FT /note="PS00211 ABC transporters family signature" FT CDS 8077..8928 FT /transl_table=11 FT /gene="ML0849" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 30.0 kDa protein Rv2325c or MTCY3G12.09 SW:YN25_MYCTU FT (P71887) (282 aa) fasta scores: E(): 0, 77.3% id in 282 aa. FT Similar other bacterial hypothetical proteins e.g. to FT Bacillus halodurans YbaF protein ybaF TR:Q9Z9J1 FT (EMBL:AB017508) (265 aa) fasta scores: E(): 3.4e-10, 24.5% FT id in 249 aa. Previously sequenced as TR:O32970 FT (EMBL:Z98741)." FT /db_xref="GOA:O32970" FT /db_xref="InterPro:IPR003339" FT /db_xref="UniProtKB/TrEMBL:O32970" FT /protein_id="CAC31230.1" FT /translation="MTSLSMSEHHVPRRRSRPVVLLVPVPGTSTIHDLWAGTKLLVVFG FT VEVLLTFYPGWVTIGLVAALVCGAAWIARIPRDVLPSMPRWLWIVVVLGGFTAALAGGS FT PVVSMGGVDIGLGGVLNFLRITAWSVVLLGLGAMVSWTTNVAEIGPAMATLGRPLRIFR FT IPVDEWAVAVALALRAFPMLINEFQVLYAARRLRPKQILNSRKARRQRQARELIDLLAA FT AITVTLRRADEMGDAITARGGIGQLSAYPARPKLADWVTLAITITTSSTAVVLETILHT FT AS" FT repeat_region complement(8997..9859) FT /note="Dispersed repeat, RLEP, copy 10" FT CDS 10010..11174 FT /pseudo FT /transl_table=11 FT /gene="ltp1" FT /gene_synonym="ML0850" FT /product="non-specific lipid transport protein FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT ltp1 (Best blastx score 347)" FT CDS complement(11353..11963) FT /pseudo FT /transl_table=11 FT /gene="sirR" FT /gene_synonym="ML0851" FT /product="iron-dependent transcriptional repressor FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT sirR (Best blastx score 192)" FT CDS 12135..13130 FT /transl_table=11 FT /gene="ribF" FT /gene_synonym="ML0852" FT /product="putative riboflavin kinase" FT /EC_number="2.7.1.26" FT /EC_number="2.7.7.2" FT /note="Similar to Mycobacterium tuberculosis riboflavin FT kinase ribF or Rv2786c or MTV002.51C TR:O33328 FT (EMBL:AL008967) (331 aa) fasta scores: E(): 0, 87.5% id in FT 327 aa and to many others e.g. Corynebacterium ammoniagenes FT riboflavin biosynthesis protein RibF (includes riboflavin FT kinase) ribF SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: FT E(): 0, 47.7% id in 321 aa. Previously sequenced as FT TR:O32968 (EMBL:Z98741). Contains Pfam match to entry FT PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase." FT /db_xref="GOA:O32968" FT /db_xref="HSSP:1N05" FT /db_xref="InterPro:IPR015865" FT /db_xref="UniProtKB/TrEMBL:O32968" FT /protein_id="CAC31233.1" FT /translation="MGSRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHTELIAH FT TVQTGRARNVPTVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELIEELGIDVFLVMPFTT FT DFMKLTPDRYVHELLVEHLHVVEVVVGENFTFGKKAAGNVIMLRRAGQRFGFAVGSMSL FT LSEHRGNETVAFSSTYIRSCVDAGDMMAATEALGRPHRVEGMVVRGQGRGTELGFPTAN FT VASPMYSATPADGVYAAWFTVLGHGPVTGTVVPGECYQAAVSVGTNPTFSGRTRTVEAF FT VLDAVADLYGQHVALDFVGRIRGQRKFDSVADLVAEMEKDIDRARALLAD" FT misc_feature 12717..13124 FT /note="Pfam match to entry PF01687 FAD_Synth, Riboflavin FT kinase / FAD synthetase, score 250.80, E-value 1.8e-71" FT RBS 13236..13242 FT /note="possible RBS" FT CDS 13248..13517 FT /transl_table=11 FT /gene="rpsO" FT /gene_synonym="ML0853" FT /product="30S ribosomal protein S15" FT /note="Similar to Mycobacterium tuberculosis 30S ribosomal FT protein S15 rpsO or Rv2785c or MTV002.50C SW:RS15_MYCTU FT (O33327) (89 aa) fasta scores: E(): 1.1e-32, 92.1% id in 89 FT aa and to Bacillus stearothermophilus 30S ribosomal protein FT S15 rpsO SW:RS15_BACST (P05766) (88 aa) fasta scores: E(): FT 7.7e-22, 62.5% id in 88 aa. Previously sequenced as FT SW:RS15_MYCLE (O32967). Contains Pfam match to entry FT PF00312 Ribosomal_S15, Ribosomal protein S15. Contains FT PS00362 Ribosomal protein S15 signature." FT /db_xref="GOA:O32967" FT /db_xref="HSSP:1A32" FT /db_xref="InterPro:IPR009068" FT /db_xref="UniProtKB/Swiss-Prot:O32967" FT /protein_id="CAC31234.1" FT /translation="MALTSEQKKEILSSYGLHATDTGSPEAQIALLTKRIADLTEHLKV FT HKHDHHSRRGLLLLVGRRRRLIKYLSLIDVQRYRSLIERLGLRR" FT misc_feature 13314..13511 FT /note="Pfam match to entry PF00312 Ribosomal_S15, Ribosomal FT protein S15, score 102.30, E-value 1.6e-27" FT misc_feature 13362..13454 FT /note="PS00362 Ribosomal protein S15 signature" FT CDS 13839..16160 FT /transl_table=11 FT /gene="gpsI" FT /gene_synonym="ML0854" FT /product="putative polyribonucleotide phosphorylase / FT guanosine pentaphosphate synthetase" FT /EC_number="2.7.7.8" FT /note="Similar to Mycobacterium tuberculosis guanosine FT pentaphosphate synthetase / polyribonucleotide FT nucleotidyltransferase gpsI or Rv2783c or MTV002.48C FT TR:O33325 (EMBL:AL008967) (752 aa) fasta scores: E(): 0, FT 90.0% id in 757 aa, to Streptomyces antibioticus guanosine FT pentaphosphate synthetase gpsI TR:Q53597 (EMBL:U19858) (740 FT aa) fasta scores: E(): 0, 67.2% id in 751 aa and to FT Bacillus subtilis polyribonucleotide nucleotidyltransferase FT pnpA or comR SW:PNPA_BACSU (P50849) (704 aa) fasta scores: FT E(): 0, 45.0% id in 723 aa. Previously sequenced as FT TR:O32966 (EMBL:Z98741). Contains Pfam match to entry FT PF00013 KH-domain, KH domain. Contains 2 Pfam matches to FT entry PF01138 RNase_PH, 3' exoribonuclease family. Contains FT Pfam match to entry PF00575 S1, S1 RNA binding domain." FT /db_xref="GOA:Q9CCF8" FT /db_xref="HSSP:1E3P" FT /db_xref="InterPro:IPR003029" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCF8" FT /protein_id="CAC31235.1" FT /translation="MSVAEIEEGVFEATVTIDNGSFGTRAIRFETGRLALQAAGAVVAY FT LDADNMLLSATTASKNPKEQFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTC FT RLIDRPLRPSFVDGLRNEIQVVVTILSVDPNDLYDVLAINAASASTQLGGLPFSGPIGG FT VRVALIDGTWVAFPTVEQLERAVFDMVIAGRIVGTDDEGKPDVAIMMVEAEATENVIEL FT VECGAQAPTESIVAQGLEVAKPFIAALCTAQQELADVVSSRQAKPPVEYPTFPDYGDDV FT YYSVASMATDELAAALTIGAKLERDQRTNEIKTQVLERLAGTYEGREKELGAAFRSLTK FT KLVRQRILTNHFRIDGRGITDIRALSAEVAVVPRAHGSALFERGETQILGVTTLDMVKM FT AQQIDSLGPETSKRYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSVEE FT FPYAIRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDVEFDGGT FT ERRFVTLTDILGAEDAFGDMDFKCAGTKDFVTALQLDTKLDGIPSQVLAGALAQAKDAR FT LTILEVMAEAIDRPDEMSPYAPRVITIKVPVDKIGEVIGPKGKVINAITEETGAQISIE FT DDGTVFVGATDGLSAQAAINKINAIANPQLPTVGERFLGTVVKITEFGAFVSLLPGRDG FT LVHISKLGKGKRIAKVEDVVNVGDKLRVEIADIEKRGKISLVLVADDDSATVPAAPADA FT GAAQEFGSGTAPADAATASS" FT misc_feature 13884..14525 FT /note="Pfam match to entry PF01138 RNase_PH, 3' FT exoribonuclease family, score 157.30, E-value 2.7e-43" FT misc_feature 14895..15563 FT /note="Pfam match to entry PF01138 RNase_PH, 3' FT exoribonuclease family, score 286.90, E-value 2.6e-82" FT misc_feature 15642..15782 FT /note="Pfam match to entry PF00013 KH-domain, KH domain, FT score 38.10, E-value 3.4e-10" FT misc_feature 15831..16043 FT /note="Pfam match to entry PF00575 S1, S1 RNA binding FT domain, score 50.40, E-value 2.7e-12" FT CDS 16249..17523 FT /transl_table=11 FT /gene="pepR" FT /gene_synonym="ML0855" FT /product="putative zinc protease" FT /note="EC_number=3.4.99.-" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT zinc protease Rv2782c or MTV002.47C SW:YR82_MYCTU (O33324) FT (438 aa) fasta scores: E(): 0, 84.3% id in 421 aa and to FT others, both bacterial and eukaryotic e.g. Homo sapiens FT mitochondrial processing peptidase beta subunit precursor FT pmpcB or mppB SW:MPPB_HUMAN (O75439) (489 aa) fasta scores: FT E(): 0, 30.6% id in 434 aa. Previously sequenced as FT SW:YR82_MYCLE (O32965). Contains Pfam match to entry FT PF00675 Peptidase_M16, Insulinase (Peptidase family M16). FT Contains PS00143 Insulinase family, zinc-binding region FT signature." FT /db_xref="GOA:O32965" FT /db_xref="HSSP:1HR6" FT /db_xref="InterPro:IPR007863" FT /db_xref="UniProtKB/Swiss-Prot:O32965" FT /protein_id="CAC31236.1" FT /translation="MCRTTLPGGLRVVTEHLPAVRSASVGVWVGVGSRDEGATVAGAAH FT FLEHLLFKSTSTRTAMDIAQAIDAVGGELNAFTAKEHTCYYAHVLDSDLELAVDLVADV FT VLNGRCAVDDVELERDVVLEEIAMRDDDPEDALGDMFLAALFGDHPVGRPVIGTMESVS FT AMTRTQLHSFHVRRYTPERMVVAVAGNVDHDEMVALVREHFGSRLIRGRQSAPPRKSTG FT RINGGPALTLGKRDAEQTHVLLGVRTPGRSWEHRWALSVLHTALGGGLSSRLFQEIRET FT RGLAYSVYSALDIFADSGALSVYAACLPGRFADVMQVISEVLASVAGDGITEAECRIAK FT GSLRGGIILGLEDSNSWMSRLGRSELNYGKYRGIEHTLQQIDEVTVEQVNALAHQLLNK FT RYGAAVLGPYASKKTLPRQLRIMVN" FT misc_feature 16276..16725 FT /note="Pfam match to entry PF00675 Peptidase_M16, FT Insulinase (Peptidase family M16), score 171.90, E-value FT 1e-47" FT misc_feature 16342..16413 FT /note="PS00143 Insulinase family, zinc-binding region FT signature" FT CDS 17528..18537 FT /pseudo FT /transl_table=11 FT /gene="ML0856" FT /product="probable oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2781c (Best blastx score 337)" FT repeat_region 19002..19602 FT /note="Dispersed repeat, RLEP, copy 11 " FT CDS complement(19690..20442) FT /transl_table=11 FT /gene="ML0857" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 26.9 kDa protein Rv2219 or MTCY190.30 SW:YM19_MYCTU FT (Q10405) (250 aa) fasta scores: E(): 0, 80.8% id in 250 aa. FT Similar to Streptomyces coelicolor putative integral FT membrane protein SC3H12.04 TR:CAB90843 (EMBL:AL355740) (234 FT aa) fasta scores: E(): 1.2e-26, 39.6% id in 230 aa and to FT Streptomyces coelicolor putative integral membrane protein FT SC5F7.05 TR:Q9S2P0 (EMBL:AL096872) (234 aa) fasta scores: FT E(): 1.2e-26, 39.6% id in 230 aa. Previously sequenced as FT TR:O32963 (EMBL:Z98741). Contains hydrophobic, possible FT membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:O32963" FT /protein_id="CAC31238.1" FT /translation="MAKPRNAAAHKAARAEAKAARKAASRQRRLQLWQAFTIQRTEDKR FT LIPYMIAAFSLMVSASVTAGVLVGGLTMITLILLGVVLGALVAFIIFGRRTQQSVYHKA FT EGQTGGAAWALDNLRGKWRVSPGVAANGHFDAVHRVIGRPGVIFVAEGSAARVKPLLAQ FT EKKRTARLVGDVPIYDIIVGNGDGEVALVKLERHLARLPANISVKQVDILESRLAALGS FT RAGASLIPKGPLPNAGKMRGVQRTVRRK" FT CDS complement(20469..21413) FT /transl_table=11 FT /gene="lipA" FT /gene_synonym="ML0858" FT /product="putative lipoic acid synthetase" FT /note="Similar to Mycobacterium tuberculosis lipoic acid FT synthetase lipA or Rv2218 or MTCY190.29 SW:LIPA_MYCTU FT (Q10380) (311 aa) fasta scores: E(): 0, 86.5% id in 310 aa. FT Similar to many e.g. Escherichia coli lipoic acid FT synthetase lipA or lip SW:LIPA_ECOLI (P25845; P77595) (321 FT aa) fasta scores: E(): 0, 42.5% id in 294 aa. Previously FT sequenced as SW:LIPA_MYCLE (O32962)." FT /db_xref="GOA:O32962" FT /db_xref="InterPro:IPR007197" FT /db_xref="UniProtKB/Swiss-Prot:O32962" FT /protein_id="CAC31239.1" FT /translation="MTVAPEDCRLLRLEVRNAQTPIERKPPWIKTRARMGPEYTALKNL FT VRRVALHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAALDRDEPR FT RVAESVQTMGLRYTTVTGVARDDLPDGGAWLYATTVRAIKELNPSTGVELLIPDFNGQP FT ARLAEVFDSRPQVLAHNVETVPRIFKRIRPAFTYQRSLDVLTAAREAGLVTKSNLILGL FT GETADEVRTALADLRKTGCDIVTITQYLRPSMRHHPVERWVRPEEFVEYTQYAEGLGFS FT GVLGGPLVRSSYRAGRLYEQAAGTRTVGTSVSR" FT CDS complement(21410..22117) FT /transl_table=11 FT /gene="lipB" FT /gene_synonym="ML0859" FT /product="putative lipoate-protein ligase B" FT /note="EC_number=6.-.-.-" FT /note="Similar to Mycobacterium tuberculosis FT lipoate-protein ligase B lipB or Rv2217 or MTCY190.28 FT SW:LIPB_MYCTU (Q10404) (230 aa) fasta scores: E(): 0, 78.4% FT id in 218 aa. Similar to Escherichia coli lipoate-protein FT ligase B lipB SW:LIPB_ECOLI (P30976) (191 aa) blastp score: FT 84.1 bits, 55% id in 163 aa. Previously sequenced as FT SW:LIPB_MYCLE (O32961). Contains Pfam match to entry FT PF02111 Lipoate_B, Lipoate-protein ligase B. Contains FT PS01313 Lipoate-protein ligase B signature." FT /db_xref="GOA:O32961" FT /db_xref="InterPro:IPR000544" FT /db_xref="UniProtKB/Swiss-Prot:O32961" FT /protein_id="CAC31240.1" FT /translation="MDSIRSIPTAIDVRQLGTVDYHIAWQLQRDLADARVAGGPDTLLL FT LQHPPVYTAGRRTQPHERPNPSLHGVPVVETDRGGKITWHGPGQLVGYPIIGLAEPLDV FT VNYVRRLEEALIKVCAELGLDTSRVNGRSGIWVPGSAGQPARKIAAIGVRVSRATTMHG FT FALNCQCDLDAFHAIVPCGISDAGVTSLSAELGRTVAVNDVRSAIAEAVNDALDGWLAL FT SWLSTPASVTSTL" FT misc_feature complement(21572..22021) FT /note="Pfam match to entry PF02111 Lipoate_B, FT Lipoate-protein ligase B, score 323.90, E-value 2.5e-128" FT misc_feature complement(21839..21886) FT /note="PS01313 Lipoate-protein ligase B signature" FT CDS complement(22182..23105) FT /transl_table=11 FT /gene="ML0860" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 31.7 kDa protein Rv2216 or MTCY190.27 SW:YM16_MYCTU FT (Q10403) (301 aa) fasta scores: E(): 0, 84.2% id in 297 aa. FT Similar to many hypothetical proteins from both bacteria FT and eukaryotes e.g. to Drosophila melanogaster CG8768 FT TR:Q9V6F9 (EMBL:AE003821) (297 aa) fasta scores: E(): FT 6.3e-26, 31.3% id in 304 aa. Previously sequenced as FT SW:YM16_MYCLE (O32960)." FT /db_xref="GOA:O32960" FT /db_xref="InterPro:IPR010099" FT /db_xref="UniProtKB/Swiss-Prot:O32960" FT /protein_id="CAC31241.1" FT /translation="MAQASRKAVVAIAGSSGMIGSALAAALRANDHLVLRIVRRTPANA FT EELHWNPESGEFDTDAITDVDAVVNLCGVNLGQRRWSGSFKQNLRDSRITPTEVLSAAV FT AEAGVKTFINASAVGYYGNTRDRVVDENDRAGTGFLAQLCQDWEGATLPAQYAGTRVIL FT ARTGMVLAQEAGVLSRMRPLFSFALGARIGNGRQYMSWISLEDEVRALLFAISHQSLSG FT PLNLTGPAPVTNAEFTTAFGRAINRPTPLMLPSFAVRAALGEFADEGLLIGQRAIPAAL FT ERAGFQFHHNTIGEALSYATTRPSQN" FT RBS complement(23117..23122) FT /note="possible RBS" FT CDS complement(23121..24713) FT /transl_table=11 FT /gene="ML0861" FT /product="putative dihydrolipoamide acyltransferase" FT /note="Similar to Mycobacterium tuberculosis FT dihydrolipoamide succinyltransferase component of FT 2-oxoglutarate dehydrogenase complex sucB or Rv2215 or FT MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: FT E(): 0, 81.8% id in 555 aa. Similar to Streptomyces FT seoulensis dihydrolipoamide acetyltransferase pdhB FT TR:Q9Z6I4 (EMBL:AF047034) (612 aa) fasta scores: E(): 0, FT 51.6% id in 614 aa and to many succinyltransferases e.g. FT Escherichia coli dihydrolipoamide succinyltransferase FT component of 2-oxoglutarate dehydrogenase complex sucB FT SW:ODO2_ECOLI (P07016) (404 aa) fasta scores: E(): 0, 38.4% FT id in 409 aa. Previously sequenced as TR:O32959 FT (EMBL:Z98741. Contains 2 Pfam matches to entry PF00364 FT biotin_lipoyl, Biotin-requiring enzymes. Contains Pfam FT match to entry PF00198 2-oxoacid_dh, 2-oxo acid FT dehydrogenases acyltransferase (catalytic domain). Contains FT 2 x PS00189 2-oxo acid dehydrogenases acyltransferase FT component lipoyl binding site." FT /db_xref="GOA:O32959" FT /db_xref="HSSP:1E2O" FT /db_xref="InterPro:IPR003016" FT /db_xref="UniProtKB/TrEMBL:O32959" FT /protein_id="CAC31242.1" FT /translation="MACSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVD FT TEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGAPSEAAAAAPAPRPEPKAQPEPAASSQ FT PAAPAQQPSGAATATPVLMPELGESVTEGTVTRWLKKIGDSVQADEPLVEVSTDKVDTE FT IPSPVAGVLVSITTNEDTTVPVGGELARIGVTLDSIATPAPAPRAESVPSRPTPARKEA FT NGAPYVTPLVRKLATENNIDLAKVIGTGVGGRIRKQDVLAAAEQRKQQQAPTSAPSAAA FT PTPTPVLAHLRGTTQKVSRIRQITAKKTRESLQATAQLTQTHEVDMAKIVGLRAKAKAA FT FAEREGVNLTFLPFIAKAAIDALKIHPNINASYNEDTKEITYYDAEHLGFAIDTDKGLL FT SPVIHYAGDLSLAGLARAIVDIAARARSGNLKPEELSGGTFTITNIGSQGALFDTPILV FT PPQAAMLGIGAIVKRPRVVIDASGNESIGVRAICYLPLTYDHRLIDGADAGRFLTTIKH FT RLEEGAFEADLGL" FT misc_feature complement(23139..23810) FT /note="Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid FT dehydrogenases acyltransferase (catalytic domain), score FT 253.30, E-value 3.4e-72" FT misc_feature complement(24138..24359) FT /note="Pfam match to entry PF00364 biotin_lipoyl, FT Biotin-requiring enzymes, score 106.40, E-value 5.6e-28" FT misc_feature complement(24198..24287) FT /note="PS00189 2-oxo acid dehydrogenases acyltransferase FT component lipoyl binding site" FT misc_feature complement(24486..24707) FT /note="Pfam match to entry PF00364 biotin_lipoyl, FT Biotin-requiring enzymes, score 110.00, E-value 4.6e-29" FT misc_feature complement(24546..24635) FT /note="PS00189 2-oxo acid dehydrogenases acyltransferase FT component lipoyl binding site" FT RBS complement(24723..24727) FT /note="possible RBS" FT RBS 24944..24949 FT /note="possible RBS" FT CDS 24953..26743 FT /transl_table=11 FT /gene="ephD" FT /gene_synonym="ML0862" FT /product="putative oxidoreductase" FT /note="Similar to Mycobacterium tuberculosis probable FT oxidoreductase ephD or Rv2214c or MTCY190.25C SW:EPHD_MYCTU FT (Q10402) (592 aa) fasta scores: E(): 0, 80.4% id in 596 aa. FT Similar to many putative oxidorecuctases e.g. Streptomyces FT coelicolor putative oxidoreductase SCD78.21C TR:Q9ZBX8 FT (EMBL:AL034355) (585 aa) fasta scores: E(): 0, 42.4% id in FT 582 aa. C-terminal half is similar to Pseudomonas FT paucimobilis C alpha-dehydrogenase ligD SW:LIGD_PSEPA FT (Q01198) (305 aa) fasta scores: E(): 1.1e-15, 26.8% id in FT 269 aa. Previously sequenced as TR:O32958 (EMBL:Z98741). FT Contains Pfam match to entry PF00561 abhydrolase, FT alpha/beta hydrolase fold. Contains Pfam match to entry FT PF00106 adh_short, short chain dehydrogenase. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature." FT /db_xref="GOA:O32958" FT /db_xref="HSSP:1PR9" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O32958" FT /protein_id="CAC31243.1" FT /translation="MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDS FT HVLWDGVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSPDRPV FT HVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARA FT VSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSV FT KTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIK FT AGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGI FT GRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV FT SAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGG FT HIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQ FT STRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYAL FT YGISRVLPQVLRSTARIRVI" FT misc_feature 25130..25858 FT /note="Pfam match to entry PF00561 abhydrolase, alpha/beta FT hydrolase fold, score 110.40, E-value 3.4e-29" FT misc_feature 25937..26494 FT /note="Pfam match to entry PF00106 adh_short, short chain FT dehydrogenase, score 191.70, E-value 1.2e-53" FT misc_feature 26345..26431 FT /note="PS00061 Short-chain dehydrogenases/reductases family FT signature" FT CDS 26901..27215 FT /transl_table=11 FT /gene="ML0863" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O32957 FT (EMBL:Z98741)." FT /db_xref="UniProtKB/TrEMBL:O32957" FT /protein_id="CAC31244.1" FT /translation="MPGQHGWLALDHIVGMRDRLVDNRHAARITVVSAPGRSEIDVEGI FT SAGNNRLVLAGTDTGHQAPITLVISTTVLSGVKISRCTVTVGLPQDFDRYQVGAARRSG FT " FT CDS complement(27286..28860) FT /transl_table=11 FT /gene="pepA" FT /gene_synonym="ML0864" FT /product="putative aminopeptidase" FT /EC_number="3.4.11.1" FT /note="Similar to Mycobacterium tuberculosis probable FT cytosol aminopeptidase pepA or pepB or Rv2213 or MTCY190.24 FT SW:AMPA_MYCTU (Q10401) (515 aa) fasta scores: E(): 0, 83.0% FT id in 522 aa. Similar to many e.g. Rickettsia prowazekii FT cytosol aminopeptidase pepA or rp142 SW:AMPA_RICPR (P27888) FT (500 aa) fasta scores: E(): 0, 39.1% id in 384 aa. FT Previously sequenced as TR:O32956 (EMBL:Z98741). Contains FT Pfam match to entry PF00883 Peptidase_M17, Cytosol FT aminopeptidase family. Contains PS00631 Cytosol FT aminopeptidase signature." FT /db_xref="GOA:O32956" FT /db_xref="HSSP:1LAM" FT /db_xref="InterPro:IPR008283" FT /db_xref="UniProtKB/Swiss-Prot:O32956" FT /protein_id="CAC31245.1" FT /translation="MPVTTDPGYQGPSVHVAASLPKHDVSSSVLIVPVVSASDSDESED FT RPGAVVAAAEPFLTAAAVAEIEAGLRALEATGGSDQVHRLVAPSLPVGSVLTVSLGKPR FT SEWPADTIRRAAGVAARSLGRAEVVITTLAELPGESGASICSAVVEGLMLGSYRFTDFR FT SRKTAPKDNGLRKITVLANAKDAKKQSAHGATVASAVATARDLVNTPPSHLFPAEFAKC FT AKTLGESAGLEVEVLDDKALQKAGYGGVIGVGQGSSRTPRLVRLIHQGSRLAKNPKNAR FT KVALVGKGITFDTGGISIKPAASMHHMTSDMAGAAAVIATITLAAQLKLPIDVVATVPM FT AENMPSGTAQRPGDVLTQYGGITVEVLNTDAEGRLILADAIVRACQDNPDYLIETSTLT FT GAQTVALGSRIPGVMGSDKFRDRVAKTSQQVGENGWPMPLPDELKDDLKSTVADLANVS FT GQRFAGMLVAGAFLREFVADGVDWAHIDIAGPAYNTDSPWGYTPKGATGVPTRTMFAML FT EDIANHG" FT misc_feature complement(27406..28644) FT /note="Pfam match to entry PF00883 Peptidase_M17, Cytosol FT aminopeptidase family, score 721.10, E-value 5.2e-213" FT misc_feature complement(27736..27759) FT /note="PS00631 Cytosol aminopeptidase signature" FT CDS 29021..30124 FT /transl_table=11 FT /gene="gcvT" FT /gene_synonym="ML0865" FT /product="putative aminomethyltransferase" FT /note="Similar to Mycobacterium tuberculosis probable FT aminomethyltransferase gcvT or Rv2211c or MTCY190.22 FT SW:GCST_MYCTU (Q10376) (379 aa) fasta scores: E(): 0, 84.7% FT id in 367 aa. Similar to many e.g. Escherichia coli FT aminomethyltransferase gcvT SW:GCST_ECOLI (P27248) (363 aa) FT fasta scores: E(): 0, 39.0% id in 364 aa. Previously FT sequenced as TR:O32955 (EMBL:Z98741). Contains Pfam match FT to entry PF01571 GCV_T, Glycine cleavage T-protein FT (aminomethyl transferase)." FT /db_xref="GOA:O32955" FT /db_xref="InterPro:IPR006223" FT /db_xref="UniProtKB/Swiss-Prot:O32955" FT /protein_id="CAC31246.1" FT /translation="MTDAPELLKGPLEDRHRELGANFAEFGGWLMPVSYAGTVSEHSAT FT RNAVGLFDVSHLGKALVRGPGAAQFVNSVLTNDLGRIRPGKAQYTLCCSESGGVIDDLI FT AYYVDDDEIFLVSNAANTAAVVDALQAVVPAGLTIINQHRSHAVLAVQGPRSTDVLGEL FT GLPTGIDYMGYVDASYAGVPVRVCRTGYTGEQGYELLPPWESADVVFDALVAAVVDARG FT EPAGLGARDTLRTEMGYPLYGHELSLDISPLQARCGWAIGWKKDAFLGRDALLAEKAAG FT PRRLLRGLRMAGRGVLRPGLTVCAGDIPIGVTTSGTFSPTLQVGVALALIDSEAAVQDG FT QQIIVDVRGRAVECEVVRPPFIEVKTR" FT misc_feature 29171..30112 FT /note="Pfam match to entry PF01571 GCV_T, Glycine cleavage FT T-protein (aminomethyl transferase), score 500.30, E-value FT 1.5e-146" FT CDS 30181..31287 FT /transl_table=11 FT /gene="ilvE" FT /gene_synonym="ML0866" FT /product="putative branched-chain-amino-acid transaminase" FT /EC_number="2.6.1.42" FT /note="Similar to Mycobacterium tuberculosis probable FT branched-chain amino acid aminotransferase ilvE or Rv2210c FT or MTCY190.21C SW:ILVE_MYCTU (Q10399) (368 aa) fasta FT scores: E(): 0, 87.2% id in 368 aa. Similar to many e.g. FT Mus musculus branched-chain amino acid aminotransferase FT (cytosolic) bcat1 or eca39 SW:BCAT_MOUSE (P24288) (386 aa) FT fasta scores: E(): 0, 41.0% id in 329 aa. Previously FT sequenced as SW:ILVE_MYCLE (O32954). Contains Pfam match to FT entry PF01063 aminotran_4, Aminotransferase class IV. FT Contains PS00770 Aminotransferases class-IV signature." FT /db_xref="GOA:O32954" FT /db_xref="HSSP:1KT8" FT /db_xref="InterPro:IPR005786" FT /db_xref="UniProtKB/Swiss-Prot:O32954" FT /protein_id="CAC31247.1" FT /translation="MTSGFLEFTVSLSAHPVTDAERESILAEPGFGKYHTDHMVSIDYI FT DGRGWHDARVIPYGPIQLDPSAIVLHYAQEVFEGLKAYRWADGSIVSFRPDANAARLRS FT SARRIAIPELPDELFIDSLCQLIAVDNAWVPRVGGEEALYLRPFIFATEPGLGVRPAKQ FT YRYLLIASPVGAYFKGGINPVTVWVSMEYVRASPGGTGAAKFGGNYAASLLAQTEAAAN FT GCDQVVWLDAVERRFVEEMGGMNIFFVLGSGGSARLVTPELSGSLLPGVTRASLLQLAI FT DAGFSVEERKIDIDEWQKKAAAGEITEVFACGTAAFITPVSRVKYGDTEFTIAGGAPGE FT VTMALRDTLTGIQRGTFADTHGWMARLG" FT misc_feature 30334..31230 FT /note="Pfam match to entry PF01063 aminotran_4, FT Aminotransferase class IV, score 493.50, E-value 1.6e-144" FT misc_feature 30898..30999 FT /note="PS00770 Aminotransferases class-IV signature" FT CDS complement(31317..32059) FT /pseudo FT /transl_table=11 FT /gene="cobS" FT /gene_synonym="ML0867" FT /product="cobalamin (5'-phosphate) synthase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT cobS (Best blastx score 348)" FT CDS complement(32056..33111) FT /transl_table=11 FT /gene="cobT" FT /gene_synonym="ML0868" FT /product="putative FT nicotinate-nucleotide-dimethylbenzimidazole FT phosphoribosyltransferase" FT /EC_number="2.4.2.21" FT /note="Similar to Mycobacterium tuberculosis putative FT nicotinate-nucleotide--dimethylbenzimidazole FT phosphoribosyltransferase cobT or Rv2207 or MTCY190.18 FT SW:COBT_MYCTU (Q10396) (361 aa) fasta scores: E(): 0, 81.4% FT id in 355 aa. Similar to many e.g. Salmonella typhimurium FT nicotinate-nucleotide--dimethylbenzimidazole FT phosphoribosyltransferase cobT SW:COBT_SALTY (Q05603) (356 FT aa) fasta scores: E(): 5.9e-32, 34.1% id in 340 aa. FT Previously sequenced as :O32953 (EMBL:Z98741)." FT /db_xref="GOA:O32953" FT /db_xref="HSSP:1D0V" FT /db_xref="InterPro:IPR017846" FT /db_xref="UniProtKB/Swiss-Prot:O32953" FT /protein_id="CAC31249.1" FT /translation="MEFAPVSPPDGHAAAAARARQDTLTKPRGALGRLEDLSIWVASCQ FT GQCPPRQFQRARIVVFAGDHGVARSGVSAYPPQLTAQMVANIDRGGAAINALASIADAT FT IRIADLAVDADPLSQQIGIHKVRRGSGDIAIQDALTEDETARAIIAGQRIADEEVDRGA FT DLLIAGDIGIGNTTAAAVLVAALTNAEPVAVVGFGTGIDDASWARKTAAVRDALCRIRL FT VLPDPVGLLRCCGGADLAAMAGFCAQAAVRRTPLLLDGMVVTAAALVAERLAPGSWQWW FT QAGHQSTEPGHALALAALDLDPILDLRMRLGEGTGATAALLVLRAAVAALTSMTTFAEA FT GVAGTSTSPPS" FT CDS complement(33201..33575) FT /transl_table=11 FT /gene="ML0869" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 14.0 kDa protein Rv2206 or MTCY190.17 SW:YM06_MYCTU FT (Q10395) (124 aa) fasta scores: E(): 0, 76.6% id in 124 aa FT and to part of Streptomyces coelicolor putative integral FT membrane protein SC5F7.32 TR:Q9S2R7 (EMBL:AL096872) (251 FT aa) fasta scores: E(): 3.5e-14, 34.7% id in 219 aa. FT Previously sequenced as TR:O32952 (EMBL:Z98741)." FT /db_xref="GOA:Q9CCF6" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCF6" FT /protein_id="CAC31250.1" FT /translation="MMAGEEAYLPPRDQGPVRRYIRDLVDARRNALGLFTPSALVLLFI FT TFGVPQLQLYMSPAMLVLLSVMGIDGIILGRKISKLVDVKFPSNTESHWRLGLYAAGRA FT SQMRRLRVPRPQVEHGSSVG" FT CDS 33725..35170 FT /pseudo FT /transl_table=11 FT /gene="ML0870" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2205c (Best blastx score 131)" FT RBS 35214..35218 FT /note="possible RBS" FT CDS 35224..35580 FT /transl_table=11 FT /gene="ML0871" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 12.5 kDa protein Rv2204c or MTCY190.15C SW:YM04_MYCTU FT (Q10393) (118 aa) fasta scores: E(): 0, 92.4% id in 118 aa. FT Similar to many hypothetical proteins e.g. Streptomyces FT coelicolor hypothetical 12.4 kDa protein SC6G10.34C FT TR:Q9X819 (EMBL:AL049497) (118 aa) fasta scores: E(): 0, FT 73.7% id in 118 aa. Contains Pfam match to entry PF01521 FT HesB-like, HesB-like domain. Contains PS01152 Hypothetical FT hesB/yadR/yfhF family signature." FT /db_xref="GOA:Q9CCF5" FT /db_xref="HSSP:1NWB" FT /db_xref="InterPro:IPR017870" FT /db_xref="UniProtKB/TrEMBL:Q9CCF5" FT /protein_id="CAC31252.1" FT /translation="MAVQNELSAKTHGVILTDVAATKAKSLLDQEGRDDLALRIAVQPG FT GCAGLRYNLFFDDRTLDGDLTAEFGGVTLTVDRMSAPYVEGASIDFVDTIEKQGFTIDN FT PNANGSCACGDSFN" FT misc_feature 35260..35577 FT /note="Pfam match to entry PF01521 HesB-like, HesB-like FT domain, score 182.00, E-value 9.4e-51" FT misc_feature 35521..35574 FT /note="PS01152 Hypothetical hesB/yadR/yfhF family FT signature" FT CDS complement(35615..36130) FT /transl_table=11 FT /gene="ML0872" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 24.4 kDa protein Rv2203 or MYCY190.14 SW:YM03_MYCTU FT (Q10392) (230 aa) fasta scores: E(): 0, 61.7% id in 230 aa. FT Contains hydrophobic, possible membrane-spanning region." FT /db_xref="UniProtKB/TrEMBL:Q9CCF4" FT /protein_id="CAC31253.1" FT /translation="MLPPAVSYPRRRSKRLIISVLVAIALVAAMTAVIIYGVRTNGSKT FT GGTFSEVTAKTAIEDYLKALEQSNINTIARNALCGMYDSVRDQRPDQALAQLSSDAFRK FT QFSQVELTSIDQIVYWSPYQAQVLFTMRTSPATGGPKRRQIQGIAQLLYRRNQVLVCSY FT MLRTADSH" FT CDS 36449..37423 FT /transl_table=11 FT /gene="ML0873" FT /product="putative carbohydrate kinase" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT sugar kinase Rv2202c or MTCY190.13C SW:YM02_MYCTU (Q10391) FT (324 aa) fasta scores: E(): 0, 83.3% id in 324 aa, and to FT Streptomyces coelicolor putative kinase SC6G10.31C FT TR:Q9X816 (EMBL:AL049497) (338 aa) fasta scores: E(): 0, FT 58.9% id in 319 aa. Shows weak similarity to known kinases FT e.g. Bacillus subtilis ribokinase rbsK SW:RBSK_BACSU FT (P36945; P96733) (293 aa) fasta scores: E(): 1.2e-07, 26.1% FT id in 283 aa. Contains Pfam match to entry PF00294 pfkB, FT pfkB family carbohydrate kinase. Contains PS00583 pfkB FT family of carbohydrate kinases signature 1." FT /db_xref="GOA:Q9CCF3" FT /db_xref="InterPro:IPR011611" FT /db_xref="UniProtKB/TrEMBL:Q9CCF3" FT /protein_id="CAC31254.1" FT /translation="MTIAVTGSIATDHLMRFPGRFSEQLLVDNLHKVSLSFLVDDLVIH FT RGGVAGNMAYAIGVLGGDVALIGAVGDDFADYRDWLQNHGVNCDSVLISKTAHTARFVC FT TTDLDMAQIGSFYTGAMSEARNIKLVDAIATIGTPELVIIGANDPAAMLGYTQECRKLG FT LAFAADPSQQLARLSGEEIRNLIDGATYLFTNDYEWDLLLSKTGWSEADVMAQIQLRVT FT TLGAKGVDLVEPDGTRVHVSVVPEAGQVDPTGVGDAFRAGFLTGRSAGLSLERSAQLGS FT LVAVLVLESTGTQQWGWDRDVAVARLAGAYGEEAAAEITVVLS" FT misc_feature 36587..36661 FT /note="PS00583 pfkB family of carbohydrate kinases FT signature 1" FT misc_feature 36587..36670 FT /note="Pfam match to entry PF00294 pfkB, pfkB family FT carbohydrate kinase, score 20.30, E-value 1.9e-05" FT CDS complement(37606..39639) FT /transl_table=11 FT /gene="asnB" FT /gene_synonym="ML0874" FT /product="putative asparagine synthetase" FT /EC_number="6.3.5.4" FT /note="Similar to Mycobacterium tuberculosis putative FT asparagine synthetase [glutamine-hydrolyzing] Rv2201 or FT mtcy190.12 SW:ASNH_MYCTU (Q10374) (652 aa) fasta scores: FT E(): 0, 83.3% id in 659 aa and to Bacillus subtilis FT asparagine synthetase [glutamine-hydrolyzing] 1 asnB or asn FT SW:ASNB_BACSU (P54420; O34902) (632 aa) fasta scores: E(): FT 0, 49.0% id in 614 aa. Contains Pfam match to entry PF00310 FT GATase_2, Glutamine amidotransferases class-II. Contains FT Pfam match to entry PF00733 Asn_synthase, Asparagine FT synthase." FT /db_xref="GOA:Q9CCF2" FT /db_xref="HSSP:1CT9" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/TrEMBL:Q9CCF2" FT /protein_id="CAC31255.1" FT /translation="MDDRRLRTLPNEAYWIAVCGLLAFVVASARADSRGSGGTNNILQA FT DHSMARAVHLMRHRGPDELSTWSDPDIDGFSGGVAFGFNRLSIIDIAHSHQPLRWGPPE FT TPNRYILVFNGEIYNYLELRDELVIRHGAAFATDGDGESIVAGFHYWGTEILTRLRGMF FT AFALWDTIAHELFCARDPFGIKPLFMATGTNGTAVASEKKCLLELAEVIRFDTQIDTRA FT LQHYTVLQYVPEPETLHRGVHRLESGCYARIRPEQLDPATTRYFVPQFAATPITSSTEQ FT TRYGEITAVLADSVAKHMRADVTVGSFLSGGIDSTAIAALAIRHNPRLITFTTGFEHEG FT FSEIDVAAASAEAIGARHIVKVVTPNEFVAALPEIVWYLDEPIADPALVPLFFVAREAR FT KHVKVVLSGEGADELFGGYRIYREPLSLKPFDYLPGPLRRSMGKVSKSLPEGMRGKNLL FT HRGSLTLEERYYGNARNFSEAQLQAVLPRFHTGWTHTDVTAAVYAESVGWDPVARMQHI FT DLFTWLRGDILAKADKMTMANSLELRVPFLDPEVFAVASRLPMQAKITRTTTKYALRRA FT LESIVPAHVLHRPKLGFPVPIRHWLRAGELLEWAYALVNSSQAEHLVNLAAVHRMLDEH FT RGGISDHSRRLWTVLIFMLWHAIFIEHSVVPQISEPQYPVQP" FT misc_feature complement(37657..38898) FT /note="Pfam match to entry PF00733 Asn_synthase, Asparagine FT synthase, score -160.90, E-value 2.9e-07" FT misc_feature complement(39070..39417) FT /note="Pfam match to entry PF00310 GATase_2, Glutamine FT amidotransferases class-II, score 56.70, E-value 1e-18" FT RBS 39769..39774 FT /note="possible RBS" FT CDS 39782..40843 FT /transl_table=11 FT /gene="ctaC" FT /gene_synonym="ML0875" FT /product="putative cytochrome C oxidase chain II" FT /EC_number="1.9.3.1" FT /note="Similar to Mycobacterium tuberculosis probable FT cytochrome C oxidase polypeptide II precursor ctaC or FT Rv2200c or MTCY190.11C SW:COX2_MYCTU (Q10375) (363 aa) FT fasta scores: E(): 0, 85.3% id in 340 aa. Shows weak FT similarity to many cytochrome oxidases e.g. to part of FT Acanthamoeba castellanii cytochrome C oxidase polypeptide FT I+II cox1/2 SW:COX1_ACACA (Q37370) (873 aa) fasta scores: FT E(): 7.1e-10, 28.5% id in 221 aa. Contains hydrophobic, FT probable membrane-spanning regions. Contains Pfam match to FT entry PF00116 COX2, Cytochrome C oxidase subunit II. FT Contains PS00078 CO II and nitrous oxide reductase FT dinuclear copper centers signature." FT /db_xref="GOA:Q9CCF1" FT /db_xref="InterPro:IPR002429" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCF1" FT /protein_id="CAC31256.1" FT /translation="MTARELVCSQRVGQGLSRRLRPLVLAVTLGVLVVTLSGCSWSDAL FT AIGWPEGITPEAHLNRQLWIGAVVASLVVGVIVWGLIFWSTIFHRKKTTDTELPRQFGY FT NMPLELVLTVTPFLIISMLFYFTVIVQDKMLYLAKDPEVVIDVTAFQWNWKFGYQRVDF FT KDGTLTYDGVDPARKKAMVSKPEGKDSHGEELVGAVRGLNTEDRAYLNFDKVETLGTTT FT EIPVLVLPAGKRIEFQLNSADVVHSFWVPKFLFKRDVMPNPVANNSVNVFQVEEITKTG FT AFVGHCAEMCGTYHSMMNFEVRVVAPNDFKAYLQQRIDGKTNAEALQVIAQPPLAVTTH FT PFDTRRGQLTNSQ" FT misc_feature 40460..40720 FT /note="Pfam match to entry PF00116 COX2, Cytochrome C FT oxidase subunit II, score 39.60, E-value 7.8e-10" FT misc_feature 40511..40675 FT /note="PS00078 CO II and nitrous oxide reductase dinuclear FT copper centers signature" FT CDS 40896..41315 FT /transl_table=11 FT /gene="ML0876" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 14.9 kDa protein Rv2199c or MTCY190.10C SW:YL99_MYCTU FT (Q10406) (139 aa) fasta scores: E(): 0, 91.4% id in 139 aa FT and to Streptomyces coelicolor hypothetical proteins e.g. FT putative integral membrane protein SC6G10.27C TR:Q9X812 FT (EMBL:AL049497) (132 aa) fasta scores: E(): 6.2e-15, 38.8% FT id in 139 aa." FT /db_xref="GOA:Q9CCF0" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCF0" FT /protein_id="CAC31257.1" FT /translation="MHIEARLFEFVAVFFVIMAVLYGVLTSMFATGGVDWVGTTALALT FT GGLALIVATFFRFVARRLDIRPEDYEGAEISDGAGELGFFSPHSWWPVLVALSGSVAAV FT GIALWLPWLIVAGVVFVLASAAGLVFEYYVGPEKH" FT CDS 41502..42383 FT /transl_table=11 FT /gene="mmpS3" FT /gene_synonym="ML0877" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis putative FT membrane protein mmpS3 or Rv2198c or MTCY190.09C FT SW:MMS3_MYCTU (Q10390) (299 aa) fasta scores: E(): 0, 69.8% FT id in 308 aa. Contains hydrophobic, possible FT membrane-spanning region." FT /db_xref="UniProtKB/TrEMBL:Q9CCE9" FT /protein_id="CAC31258.1" FT /translation="MSGPNPPGRENEESDSGNELSGELDPHNGVESVDELVPVPDSDLV FT TASDHTSETEVYSQAYSAPEAEHFTAVPYVPADLRLYDYDESSVYDEPGAAPRWPWVVG FT VAAILAAISLVVSVSLLFTRTDTSKLSTPTTGRSTPPVQDEITTVKPPPPSTETSTATE FT TQTVTVTPLPPPSATSTAVPPSSVVPPPPTTPTTTVTTLTGPRQVTYSVTGTKAPGDII FT SVTYVDASGRRRTQHNVYIPWSMTVTPISQSDVGSVEAFSLFRVSKLNCLITTSDGTVL FT SSNSNDAPQTSC" FT CDS 42383..43021 FT /transl_table=11 FT /gene="ML0878" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 15.7 kDa protein Rv0008c or MTCY10H4.07C SW:Y008_MYCTU FT (P71577) (214 aa) fasta scores: E(): 0, 62.6% id in 211 aa FT and to Mycobacterium tuberculosis hypothetical 22.5 kDa FT protein Rv2197c or MTCY190.08C SW:YL97_MYCTU (Q10389) (214 FT aa) fasta scores: E(): 0, 62.6% id in 211 aa." FT /db_xref="UniProtKB/TrEMBL:Q9CCE8" FT /protein_id="CAC31259.1" FT /translation="MMNRYSPYRRGSDTIASDVIDRILVGVCAAVWLVLIGVSVAAAVA FT LEDLGRGFHKIASDPHTTWVLYGIIVVSVLIIAGAVPVLLWARRVARVEPPIRPAGVPE FT RGGVRQLVSAGRSTARIEVERVCAEERVQSVAQPGEWFDAAVDRIWLRGTVGLTGTMGA FT ALVAVAASTYLMAVGRDGASWVGYVLAGIVTAVMPVIEWIYVRQLRRVG" FT CDS complement(43155..44810) FT /transl_table=11 FT /gene="qcrB" FT /gene_synonym="ML0879" FT /product="putative cytochrome B" FT /note="Similar to Mycobacterium tuberculosis FT ubiquinol-cytochrome C reductase cytochrome B subunit qcrB FT or Rv2196 or MTCY190.07 SW:QCRB_MYCTU (Q10388) (549 aa) FT fasta scores: E(): 0, 92.5% id in 548 aa and to FT Streptomyces lividans ubiquinol-cytochrome C reductase FT cytochrome b subunit qcrB SW:QCRB_STRLI (Q9ZFB6) (549 aa) FT fasta scores: E(): 0, 44.8% id in 533 aa. N-terminal half FT is similar to some cytochomes e.g. Bacillus FT stearothermophilus menaquinol-cytochrome C reductase FT cytochrome B subunit qcrB SW:QCRB_BACST (Q45658) (224 aa) FT fasta scores: E(): 1.1e-13, 27.1% id in 207 aa. Contains FT hydrophobic, probable membrane-spanning regions. Contains FT Pfam match to entry PF00033 cytochrome_b_N, Cytochrome FT b(N-terminal)/b6/petB." FT /db_xref="GOA:P15878" FT /db_xref="InterPro:IPR005797" FT /db_xref="UniProtKB/Swiss-Prot:P15878" FT /protein_id="CAC31260.1" FT /translation="MSPKSVPDIGDVLARQAEDIDTRYHPSAALRRQLNKVFPTHWSFL FT LGEIALYSFIVLLLTGVYLTLFFDPSMTDVTYNGVYQPLRGVEMSRAYQSTLDISFEVR FT GGLFVRQIHHWAALMFTAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEGYFGY FT SMPDDLLSGIGLRAALSSITLGIPVIGTWLHWALFGGDFPGTILIPRLYALHILLIPGV FT ILALIGLHLALVWFQKHTQFPGPGRTEYNVVGVRVMPVFAFKSGAFFAAIVGVLGLMGG FT FLQINPIWNLGPYKPSQVSAGSQPDFYMMWTEGLARIWPAWEFYFWHHTIPAPVWVAVI FT MALVFVLLITYPFLEKRFTGDYAHHNLLQRPRDVPVRTSIGAMAITFYMVLTLAAMNDI FT IALKFHISLNATTWIGRIGMVILPLLVYFITYRWCIGLQRSDRAVLEHGIETGIIKRLP FT HGAYIELHQPLGPVDDHGHPIPLEYQGTAVPKRMNKLGSAGSPSSGSFLFADPVSEDAA FT LREATHVAEQRALTALREHQDSIASSPNGERGKH" FT misc_feature complement(44097..44747) FT /note="Pfam match to entry PF00033 cytochrome_b_N, FT Cytochrome b(N-terminal)/b6/petB, score 32.60, E-value FT 3.5e-08" FT CDS complement(44807..45991) FT /transl_table=11 FT /gene="qcrA" FT /gene_synonym="ML0880" FT /product="putative Rieske iron-sulphur reductase component" FT /note="Similar to Mycobacterium tuberculosis putative FT ubiquinol-cytochrome C reductase iron-sulfur subunit qcrA FT or Rv2195 or MTCY190.06 SW:QCRA_MYCTU (Q10387) (429 aa) FT fasta scores: E(): 0, 80.9% id in 398 aa. Contains FT hydrophobic, probable membrane-spanning regions. Contains FT PS00200 Rieske iron-sulfur protein signature 2." FT /db_xref="GOA:Q9CCE7" FT /db_xref="HSSP:1G8J" FT /db_xref="InterPro:IPR017941" FT /db_xref="UniProtKB/TrEMBL:Q9CCE7" FT /protein_id="CAC31261.1" FT /translation="MSLNPKDGAGASRELDETTQGTMSREELVALGGRLDGVNTVYKEQ FT RWPIEGTKAEKRTERMVTFWLLLGGVLGLTLLLIFLFWPWEYKPKEASGSFLYTIATPL FT YGLTFGLSILAIAIGAVQFQKRFIPEEISIQERHDGASPEIDRKTVVANLTDALESSTI FT RRRKLIGLSLGVGLGAFGLSTLVTFIGGFIKNPWKPVVPTANGMKAMLWTSGWTPRYHG FT ETIYLARATGSHSGAPFIRMRPEDVDAGGMETVFPWRESDGDGTTMESHEKLITIKMGI FT RNPVMLIRIRPSDMPRVVKRRGQENFNFGEFFAFTKVCSHLGCPSSLYEQQSYRILCPC FT HQSQFDALQYAKPIFGPAARALAQLPITIDTDGYLVANGDFVEPVGPAFWERTT" FT misc_feature complement(44963..44980) FT /note="PS00200 Rieske iron-sulfur protein signature 2" FT CDS complement(45988..46857) FT /transl_table=11 FT /gene="qcrC" FT /gene_synonym="ML0881" FT /product="putative cytochrome C reductase cytochrome C FT component" FT /note="Similar to Mycobacterium tuberculosis FT ubiquinol-cytochrome C reductase cytochrome C subunit qcrC FT or Rv2194 or MTCY190.05 SW:QCRC_MYCTU (Q10386) (280 aa) FT fasta scores: E(): 0, 84.4% id in 289 aa and to FT Streptomyces coelicolor cytochrome C heme-binding subunit FT SC6G10.23C TR:Q9X808 (EMBL:AL049497) (269 aa) fasta scores: FT E(): 0, 48.9% id in 266 aa. Previously sequenced as FT SW:QCRC_MYCLE (O69583). Contains Pfam match to entry FT PF00034 cytochrome_c, Cytochrome c. Contains 2 x PS00190 FT Cytochrome C family heme-binding site signature." FT /db_xref="GOA:O69583" FT /db_xref="HSSP:1C6S" FT /db_xref="InterPro:IPR009152" FT /db_xref="UniProtKB/Swiss-Prot:O69583" FT /protein_id="CAC31262.1" FT /translation="MKKLGFTRSSRRCSQPQEREQESERSRRRLRRRLSEGLLLLVALT FT VSGGLAAVLTPTPQVAVADEDSSALLRTGKQLFDTSCVSCHGANLQGVPDHGPSLIGVG FT EAAVYFQVSTGRMPAMRGEAQVARKDPIFNESQIDAIGAYIQANGGGPTVARNPDGSVA FT MQSLRGTDLGRGGDLFRLNCASCHNFTGKGGALSSGKYAPDLGPANEQQILTAMLTGPQ FT NMPKFADRQLSFEAKKDIIGYVRTVIEERQPGGYSLGGFGPAPEGMAIWIIGMVTAIGL FT ALWIGARA" FT misc_feature complement(46114..46350) FT /note="Pfam match to entry PF00034 cytochrome_c, Cytochrome FT c, score 58.10, E-value 1.9e-13" FT misc_feature complement(46294..46311) FT /note="PS00190 Cytochrome C family heme-binding site FT signature" FT misc_feature complement(46597..46614) FT /note="PS00190 Cytochrome C family heme-binding site FT signature" FT CDS complement(46919..47527) FT /transl_table=11 FT /gene="ctaE" FT /gene_synonym="ML0882" FT /product="cytochrome C oxidase subunit III" FT /note="Similar to Mycobacterium tuberculosis probable FT cytochrome C oxidase polypeptide III ctaE or Rv2193 or FT MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: FT E(): 0, 90.1% id in 203 aa. Similar to many e.g. FT Synechococcus vulcanus cytochrome C oxidase polypeptide III FT ctaE SW:COX3_SYNVU (P50677) (201 aa) fasta scores: E(): FT 1.2e-23, 39.0% id in 200 aa. Previously sequenced as FT TR:O69582 (EMBL:AL022602). Contains hydrophobic, probable FT membrane-spanning regions. Contains Pfam match to entry FT PF00510 COX3, Cytochrome c oxidase subunit III." FT /db_xref="GOA:O69582" FT /db_xref="InterPro:IPR013833" FT /db_xref="UniProtKB/Swiss-Prot:O69582" FT /protein_id="CAC31263.1" FT /translation="MTSTVGTLGTAITSRVHSLNRPNMVSVGTVVWLSSELMFFAGLFA FT MYFTARAQAGGKWPPSTELNLYQAVPVTLVLIASSFTCQMGVFSAERGDVFGLRRWYVI FT TLLMGLFFVLGQGYEYYHLITHGTTIPSSAYGSVFYLATGFHGLHVTGGLIAFIFLLAR FT TTMSKFTPAQATASIVVSYYWHFVDIVWIALFTVIYFIR" FT misc_feature complement(46928..47458) FT /note="Pfam match to entry PF00510 COX3, Cytochrome c FT oxidase subunit III, score -100.70, E-value 5.1e-10" FT CDS 47664..48764 FT /transl_table=11 FT /gene="trpD" FT /gene_synonym="ML0883" FT /product="putative anthranilate phosphoribosyltransferase" FT /EC_number="2.4.2.18" FT /note="Similar to Mycobacterium tuberculosis anthranilate FT phosphoribosyltransferase trpD or Rv2192c or MTCY190.03C FT SW:TRPD_MYCTU (Q10382) (370 aa) fasta scores: E(): 0, 80.1% FT id in 362 aa. Similar to many e.g. Streptomyces coelicolor FT anthranilate phosphoribosyltransferase 1 trpD1 or FT SC6G10.20C SW:TRD1_STRCO (O68608) (354 aa) fasta scores: FT E(): 0, 48.8% id in 363 aa. Previously sequenced as FT SW:TRPD_MYCLE (O69581). Contains Pfam match to entry FT PF00591 Glycos_transf_3, glycosyl transferase family." FT /db_xref="GOA:O69581" FT /db_xref="HSSP:1KGZ" FT /db_xref="InterPro:IPR017459" FT /db_xref="UniProtKB/Swiss-Prot:O69581" FT /protein_id="CAC31264.1" FT /translation="MVLSSQPPSSRSATGSVLSWPQVLGRLTAGQDLTRGQAAWAMGQV FT MTGNARPAQIAAFAVAMKMKVPTAAEVSELADVMLSHARKLPTEAICQDIGETVDIAGT FT GGDGANTVNLSTMAAIVVAAAGVPVVKHGNRASSSLSGGADTLEALGVRIDLGPEQVAN FT SLAEIGIGFCFAPLFQPSYRYASAVRHEIGVPTVFNILGPLTNPAWPRAGLIGCAFGNL FT AEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVQAGTVDKLTFDPVEFGFARAH FT LDDLLGGDAQTNAAKVRAVLAGAKGPVRDAVVLNAAGAIVAYAGLSSHAEWSPAWDDGL FT ARASAAIDSGAAEQLLARWVRFSQQV" FT misc_feature 47727..48191 FT /note="Pfam match to entry PF00591 Glycos_transf_3, FT glycosyl transferase family, score 251.50, E-value 1.1e-71" FT CDS complement(48642..50388) FT /pseudo FT /transl_table=11 FT /gene="ML0884" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2191 (Best blastx score 194)" FT RBS 50952..50956 FT /note="possible RBS" FT CDS 50963..52087 FT /transl_table=11 FT /gene="ML0885" FT /product="putative secreted protein" FT /note="Similar to Mycobacterium tuberculosis putative FT secreted protein Rv2190c or MTCY190.01c or MTV021.23C FT SW:YL90_MYCTU (Q10383; O53524) (385 aa) fasta scores: E(): FT 0, 69.2% id in 386 aa. Similar to many putative secreted FT proteins from Streptomyces coelicolor e.g. putative NPL/P60 FT family secreted protein SCD63A.04C TR:CAB92656 FT (EMBL:AL356832) (347 aa) fasta scores: E(): 1.4e-13, 31.7% FT id in 357 aa. Previously sequenced as TR:O69580 FT (EMBL:AL022602). Contains a probable N-terminal signal FT sequence. Contains Pfam match to entry PF00877 NLPC_P60, FT NLP/P60 family." FT /db_xref="InterPro:IPR000064" FT /db_xref="UniProtKB/TrEMBL:O69580" FT /protein_id="CAC31266.1" FT /translation="MRLGCKHPVVRLIAHFVVGTLVGFAVLSRFFVATAMADPAEDALA FT KLNELSRQAEQTTEAVHSAQLDLTEKLAAQRAADKKYTDDQAALADAQVRLATFQAAVN FT KLAAATYMSGRINGMTALLTAYSPQQLINKLALQRVLGVQMATQMAGYRDAGEQAVKAE FT QTSAKSAADAKHAADQAAVVRAGLQSKQSKLQLQIAVVKSHYLSLSPRQRTTLAEPGPV FT PAVATLPGAASAGVSPPPDAAPPGGLLGVAPAPFAGGGDRAAVVQAALTQIGSPYAWGG FT AAPGGFDCSGLVMWAYQQAGIALPHSSQALARGGQPVSLSELQPGDVLTFYSDASHAGI FT YVGDGMMIHSSTYGVPVRVVPMNSSGPIYDARRY" FT misc_feature 51767..52084 FT /note="Pfam match to entry PF00877 NLPC_P60, NLP/P60 FT family, score 125.30, E-value 1.1e-33" FT CDS 52132..53286 FT /transl_table=11 FT /gene="ML0886" FT /product="possible glycosyl transferase." FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein TR:O69579 (EMBL:AL022602) (384 aa); FT Fasta score E(): 0, 99.7% identity in 384 aa FT overlap(EMBL:AL022602). Also similar to Mycobacterium FT tuberculosis hypothetical protein TR:O53522 (EMBL:AL021957) FT (399 aa); Fasta score E(): 0, 81.5% identity in 383 aa FT overlap(EMBL:AL021957) and several Streptomyces coelicolor FT putative glycosyl transferases e.g. TR:Q9X7Z1 FT (EMBL:AL049497) (412 aa); Fasta score E(): 0, 52.2% FT identity in 387 aa overlap(EMBL:AL049497). Contains Pfam FT match to entry PF00534 Glycos_transf_1, Glycosyl FT transferases group 1." FT /db_xref="GOA:O69579" FT /db_xref="InterPro:IPR001296" FT /db_xref="UniProtKB/TrEMBL:O69579" FT /protein_id="CAC31267.1" FT /translation="MSRVLLVTNDFPPRRGGIQSYLGEFVDRLINIGSHDVMVYAPQWT FT GADTFDNAAHDGGYQVVRHPGTLMLPGPAVDARMRRLIVDHGIDTVWFGSAAPLALLAP FT CARKAGATRVLASTHGHEVGWSMLPVARSVLRRIGDVTDVVTFVSRYTRSRVTAAFGPR FT AALEYLPPGVDADRFRPDPASRAELRNRYRLGERPTVVCLARLVPRKGQDMLIRALPSI FT RQRADGAALMIVGGGPYLGTLRKLAQGCGVADHVIFAGGVAAVEVPAHYTLADVFAMPC FT RTRGGGMDVEGLGIVFLEASATGVPVIAGKSGGAPEAVQHNKTGLVVDGRSVNMVADAV FT TELLTDRDRAAAMGAAGRHWVTAEWRWDTLAARLADLLCGNDSR" FT misc_feature 52681..53211 FT /note="Pfam match to entry PF00534 Glycos_transf_1, FT Glycosyl transferases group 1, score 180.10, E-value FT 3.7e-50" FT CDS complement(53283..55085) FT /transl_table=11 FT /gene="ML0887" FT /product="putative long-chain-fatty-acid-CoA ligase" FT /note="The C-terminus of the predicted product of this CDS FT is identical to the previously sequenced Mycobacterium FT leprae putative long-chain- fatty-acid-CoA ligase TR:O69578 FT (EMBL:AL022602) (351 aa); Fasta score E(): 0, 100.0% FT identity in 351 aa overlap(EMBL:AL022602). Also similar to FT Mycobacterium tuberculosis putative FT long-chain-fatty-acid-CoA ligase, fadD15, TR:O53521 FT (EMBL:AL021957) (600 aa); Fasta score E(): 0, 80.3% FT identity in 600 aa overlap(EMBL:AL021957) and Haemophilus FT influenzae putative long-chain-fatty-acid-CoA ligase (EC FT 6.2.1.3) SW:LCFH_HAEIN (SW:P44446) (607 aa); Fasta score FT E(): 0, 30.3% identity in 587 aa overlap(SW:P44446). FT Contains Pfam match to entry PF00501 AMP-binding, FT AMP-binding enzyme. Contains PS00455 Putative AMP-binding FT domain signature." FT /db_xref="GOA:Q9CCE6" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q9CCE6" FT /protein_id="CAC31268.1" FT /translation="MREFSVPTRFSVGEHDNIAAVVFEHERDDPNLVIYQRQIDGVWTD FT VTCAEAASQIRSAALGLIALGMQAGDRVSIFSATCFEWAILDLAILSVGAVTVPIYETS FT SAKQVRWILQDSDAVLVFAETDAHATMVNQLAGELPALRQVLQINSAGATALDQLAEAG FT ASVDVAQLANRLKTLRAQDPATLIYTSGTTGRPKGCQLTHSNLLYEVRGAKECLPTLLQ FT PGQRLLVFLPLAHVLARALTLSAFTYKMTVGFTSDIKNLLPMLAVFKPTVVVSVPRVFE FT KVYNTAEQNAANEGKSRIFAMAAQTAVEWSEASHRGGPGLLLRARHAVFDRLVYRKLRA FT ALGGDCHASVSGGAPLGARLGHFYRGVGLTIHEGYGLTETSAAITLNQAGNVKVGTVGN FT LLPGNSMRIADDGELLVRGNVVFSGYWHNEQGTIEAFTEGWFKTGDLGAIDEDGFLTIT FT GRKKEIIVTAGGKNVAPALLEDQLRAHPLISQALVVGDAKPFVGALITIDPEAFNGWKQ FT RNSKAADAAIGDLTTDPDLVAEVDAAVKQANLSVSHAESIRKFRILPVDFTEQTGELTP FT TMKVKRNVVAQKFASDIEAIYEKD" FT misc_feature complement(53607..54947) FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score -44.40, E-value 6.1e-13" FT misc_feature complement(54495..54530) FT /note="PS00455 Putative AMP-binding domain signature" FT RBS complement(55093..55097) FT RBS 55253..55256 FT CDS 55260..55667 FT /transl_table=11 FT /gene="ML0888" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein TR:O69576 (EMBL:AL022602) (135 aa); FT Fasta score E(): 0, 100.0% identity in 135 aa FT overlap(EMBL:AL022602). Also similar to Mycobacterium FT tuberculosis hypothetical protein TR:O53520 (EMBL:AL021957) FT (129 aa); Fasta score E(): 0, 80.0% identity in 130 aa FT overlap(EMBL:AL021957)." FT /db_xref="UniProtKB/TrEMBL:O69576" FT /protein_id="CAC31269.1" FT /translation="MNSTNSIQIADETYVAADRALIGAAVADRSSWHRWWPDLRLQVVE FT DRAEKGIRWAVTGTLTGTMEIWLEPLTEELDGVVLHYFLHAEPAGVAAWQLAKMNMAKV FT THRRRVAGKAMAFEVKKTLERSRSIGVSPVI" FT CDS 55786..56220 FT /transl_table=11 FT /gene="ML0889" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein TR:O53519 (EMBL:AL021957) (144 aa); FT Fasta score E(): 0, 84.7% identity in 144 aa overlap FT (EMBL:AL021957) (144 aa); Fasta score E(): 0, 84.7% FT identity in 144 aa overlap(EMBL:AL021957). Also highly FT similar to Mycobacterium tuberculosis hypothetical protein FT TR:O53519(EMBL:AL021957)." FT /db_xref="InterPro:IPR005031" FT /db_xref="UniProtKB/TrEMBL:O69575" FT /protein_id="CAC31270.1" FT /translation="MADKTTQTFYIDANPGEVMKTIADIESYPQWISEYKEVEVLEVDD FT EDFPKRARMLMDAKIFKDTLIMSYDWTADHQSVSWILESSSLLKSLEGSYRLVPKGSTT FT EVTYELAVDFAIPMIGMLKRKAEHRLIDGALKDLKKRVEG" FT CDS 56241..57488 FT /transl_table=11 FT /gene="ML0890" FT /product="possible membrane transport ATPase" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein TR:O69574 (EMBL:AL022602) (415 aa); FT Fasta score E(): 0, 99.8% identity in 415 aa FT overlap(EMBL:AL022602). Also highly similar, in parts, to FT Mycobacterium tuberculosis hypothetical protein TR:O53518 FT (EMBL:AL021957) (379 aa); Fasta score E(): 0, 79.4% FT identity in 378 aa overlap(EMBL:AL021957) and weakly FT similar to many anion-transporting ATPases e.g. FT SW:ARA2_ECOLI (SW:P52145) (583 aa); Fasta score E(): FT 5.2e-07, 29.6% identity in 314 aa overlap(SW:P52145). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:O69574" FT /db_xref="HSSP:1IHU" FT /db_xref="InterPro:IPR003348" FT /db_xref="UniProtKB/TrEMBL:O69574" FT /protein_id="CAC31271.1" FT /translation="MPASAQISLFVGKGGVGKSTLAAATAVRDAGEGRRVLVVSTDQAH FT SLGDVLGVVVAPTGHGNPVRVLGCDAEAGGGFLDALALDTLALLEARWCDVVDALDRRF FT PESELGSIAPEELSALPGIQEMLGLYTVGEFATAGRWDRIVVDCASTADVLRMLTLPST FT VGLYVERAWPRHRRLSIAAGDAPSAAVVELLERISTSVERLGALLTDGSLVSAHLVLTP FT ERVVAAEAVRTLGSLALMGIRVEELIVNQVLVRNKFYEYRSLLDHPVFCWYTERICEQR FT AVLDNLDSTIGDVALVVIPYLSGEPIGPKALAELLDVAHRRRGPAPMGPLRPIVDLESG FT SGLESVYRLRLALPQLDFAALTLGRVDDDLIISAGGTRCRVRLASVLRRCMVLGAQLRG FT SELTVRFRPDPEVWPI" FT misc_feature 56274..56297 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 57485..57877 FT /transl_table=11 FT /gene="ML0891" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein TR:O69573 (EMBL:AL022602) (130 aa); FT Fasta score E(): 0, 100.0% identity in 130 aa overlap. Also FT highly similar to Mycobacterium tuberculosis hypothetical FT protein Rv2183c TR:O53517 (EMBL:AL021957) (131 aa); Fasta FT score E(): 1.3e-30, 62.6% identity in 131 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O69573" FT /protein_id="CAC31272.1" FT /translation="MSGGYADIGPELRKLAQMTLDGIGPAVRSAAALVAGARGTGKCQQ FT AWCPVCALTALVIGEQHPLLTVIADHSVALLDVIRAIVDDIDQSNKIPPDSPHGGGLDT FT ETPAQTNTSNGTVRRRYQPIPVSVED" FT RBS 57956..57959 FT CDS 57963..58697 FT /transl_table=11 FT /gene="ML0892" FT /product="possible acyltransferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O69572 (EMBL:AL022602) (244 FT aa); Fasta score E(): 0, 100.0% identity in 244 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2182c TR:O53516 (EMBL:AL021957) (247 FT aa); Fasta score E(): 0, 79.8% identity in 247 aa overlap FT and several Streptomyces coelicolor putative FT acyltransferases e.g. TR:CAB76086 (EMBL:AL157956) (223 aa); FT Fasta score E(): 0, 51.1% identity in 221 aa overlap. FT Contains Pfam match to entry PF01553 Acyltransferase, FT Acyltransferase." FT /db_xref="GOA:O69572" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/TrEMBL:O69572" FT /protein_id="CAC31273.1" FT /translation="MWYWLFKYIFMGPALSVLGRPKVEGLEYVPSSGPAILASNHLAVA FT DSFYLPLVVRRRITFLAKSEYFTGTGLKGWFTSWFYRATGQVPIDRTDADTAEAALNTA FT ERLLGHGKLIGMYPEGTRSPDGRLYKGKTGVARLTLQTGVPVIPVAMIGTNVVNPPGSK FT MWRFGRVTVRFGKPMDFSRFEGAAGNRVIERVITDEVIYELMELSGQEYVDIYAASVKG FT HSSSSGAKLTNEAVRIPDTAVG" FT misc_feature 58038..58583 FT /note="Pfam match to entry PF01553 Acyltransferase, FT Acyltransferase, score 154.60, E-value 1.6e-42" FT CDS complement(58705..59991) FT /transl_table=11 FT /gene="ML0893" FT /product="probable conserved integral membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative integral membrane protein TR:O69571 FT (EMBL:AL022602) (428 aa); Fasta score E(): 0, 100.0% FT identity in 428 aa overlap(EMBL:AL022602). Also highly FT similar to Mycobacterium tuberculosis putative membrane FT protein TR:O53515 (EMBL:AL021957) (427 aa); Fasta score FT E(): 0, 80.0% identity in 431 aa overlap(EMBL:AL021957). FT Contains multiple possible membrane spanning hydrophobic FT domains and a possible N-terminal signal sequence." FT /db_xref="InterPro:IPR018584" FT /db_xref="UniProtKB/TrEMBL:O69571" FT /protein_id="CAC31274.1" FT /translation="MSRQQTPEVGNKHRQIGRCCLLWLLAVTALGQVAWQLLGHTPYRI FT DIDIYQMGGQAWLDGRPLYSGDVLFHTPIGLNLPFTYPPLAAIAFCPFAWLHMPAASVA FT ITLTTLMLLIVSTIIVLTRLDVWAMSRAVPGPAWLRRLWLAVIIVSPAAIWLEPISSNF FT AFGQINVVLMTLVIADCVPRRTPWPRGLMLGLGIALKLTPAVFLLYFVLRRDNRAALTS FT WASFAGATLVGFVLAWRDSWEYWTHTVHNTERIGAAALNTDQNIAGALARLGLGEHERF FT LLWAAGCLLVLAATAWAMLRVLRAGEPMLAVICVALFGLVVSPVSWSHHWVWMLPAVLV FT TGILSWRRQNVAVAVISAAGVALMRWTPIGLLPQHQETTAVWWRQLAGMSYVWWALAVI FT VATGLTVTTRVTSQDSATQTLLTPVSTAS" FT CDS 60118..60871 FT /pseudo FT /transl_table=11 FT /gene="ML0894" FT /product="probable integral membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2180c (Best blastx score 217)" FT CDS 61008..61523 FT /transl_table=11 FT /gene="ML0895" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O69570 (EMBL:AL022602) (171 FT aa); Fasta score E(): 0, 100.0% identity in 171 aa FT overlap(EMBL:AL022602) and highly similar to Mycobacterium FT tuberculosis hypothetical protein TR:O53513 (EMBL:AL021957) FT (168 aa); Fasta score E(): 0, 83.1% identity in 166 aa FT overlap(EMBL:AL021957)." FT /db_xref="UniProtKB/TrEMBL:O69570" FT /protein_id="CAC31276.1" FT /translation="MRYFYDTEFIEDGRTIELVSIGVVAEDGREYYAVSNEFDPERAGN FT WVRVNVLSKLPPLASQLWRSRRQIRLDLEEFFGVDGSEPTEPIELWAWVGAYDHVALCQ FT LWGPMPDLPEALPRFTREIRQLWEDRGCPRMPPRPRDLHDALVDARDQLRRFRIIMSAD FT DVGSLPTH" FT CDS 61587..62975 FT /transl_table=11 FT /gene="aroG" FT /gene_synonym="ML0896" FT /product="3-deoxy-D-arabino-heptulosonate 7-phosphate FT synthase (DAHP synthetase)." FT /note="Identical to the previously sequenced Mycobacterium FT leprae 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase FT TR:O69569 (EMBL:AL022602) (462 aa); Fasta score E(): 0, FT 100.0% identity in 462 aa overlap(EMBL:AL022602). Also FT highly similar to many others e.g. Mycobacterium FT tuberculosis 3-deoxy-D-arabino-heptulosonate 7-phosphate FT synthase TR:O53512 (EMBL:AL021957) (462 aa); Fasta score FT E(): 0, 89.7% identity in 465 aa overlap(EMBL:AL021957) and FT similar to many plant DAHP synthetase family proteins e.g. FT Arabidopsis thaliana SW:AROF_ARATH (SW:P29976) (525 aa); FT Fasta score E(): 0, 49.0% identity in 441 aa FT overlap(SW:P29976). Contains Pfam match to entry PF01474 FT DAHP_synth_2, Class-II DAHP synthetase family." FT /db_xref="GOA:O69569" FT /db_xref="InterPro:IPR002480" FT /db_xref="UniProtKB/TrEMBL:O69569" FT /protein_id="CAC31277.1" FT /translation="MNWTVDIPIDQLPPLPADLRARLDAALAKPAAQQPSWPTDQAAAM FT RTVLESVPPVTVPSEIIRLQEQLALVANGKAFLLQGGDCAETFVDNTEPHIRSNVRTLL FT QMAVVLTYGASLPVVKVARIAGQYAKPRSADVDALGLKSYRGDMINGFAPDAAAREHDP FT SRLVRAYANSSAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALAGEIGRGL FT AFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLAGAPEGPDDGLQLYDLSAHTVWI FT GERTRQLDGAHVAFAEVIANPIGVKMGATMTPELAVEYVERLDPHNKPGRLTLVSRLGN FT NKVRDVLPPIVEKVKATGHQVIWQCDPMHGNTHESSTGYKTRHFDRVVDEVQGFFEVHR FT ALGTYPGGIHVEITGEDVTECLGGAQDISDTDLAGRYETACDPRLNTQQSLELAFLVAE FT MLRD" FT misc_feature 61644..62957 FT /note="Pfam match to entry PF01474 DAHP_synth_2, Class-II FT DAHP synthetase family, score 1026.80, E-value 0" FT CDS complement(62988..64190) FT /transl_table=11 FT /gene="ML0897" FT /product="serine-threonine protein kinase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative serine/threonine protein kinase TR:O69568 FT (EMBL:AL022602) (400 aa); Fasta score E(): 0, 99.8% FT identity in 400 aa overlap(EMBL:AL022602). Also highly FT similar to many other putative serine/threonine protein FT kinases e.g. from Mycobacterium tuberculosis: TR:O53510 FT (EMBL:AL021957) (399 aa); Fasta score E(): 0, 75.3% FT identity in 400 aa overlap(EMBL:AL021957) and SW:PKNB_MYCTU FT (SW:P71584) (626 aa); Fasta score E(): 2e-31, 39.5% FT identity in 311 aa overlap(SW:P71584). Contains Pfam match FT to entry PF00069 pkinase, Eukaryotic protein kinase domain. FT Contains PS00108 Serine/Threonine protein kinases FT active-site signature. Contains PS00107 Protein kinases FT ATP-binding region signature." FT /note="Similar to ML0016 and ML0017" FT /db_xref="GOA:O69568" FT /db_xref="HSSP:1MRU" FT /db_xref="InterPro:IPR017441" FT /db_xref="UniProtKB/TrEMBL:O69568" FT /protein_id="CAC31278.1" FT /translation="MLDGRYLLKAKIGNGGTATVYRGVDIRLDRPVAVKVMDSRYTGDE FT QLLTRFQLEARSVARLKDPGLVAVYDQGIDARHPFLVMELIEGGTLRELLAERGPMPPH FT AVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKIADFGLVRAVAAAGITSTS FT VILGTVAYLSPEQVRDGDASPRSDVYSAGIMTYELLTGHTPFTGDSALSIAYQRLEIDV FT PRASTVITGVPQQFDELVARATVRDPSGRYADAIEMAAQVDSIAEELALPPFRVPAPRN FT TAQYRSAALHRGHMVERPVEQQVQPVVNAPMPHSTRQFTRRLRDCSAPRRPARPDIDSP FT EEYEYEPVPDRFAGIAISEFIWARQHARRMVLIWVGVVVAIAGLVATVAWTIGSHLSGL FT L" FT misc_feature complement(63576..64175) FT /note="Pfam match to entry PF00069 pkinase, Eukaryotic FT protein kinase domain, score 183.90, E-value 2.5e-51" FT misc_feature complement(63780..63818) FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT misc_feature complement(64086..64157) FT /note="PS00107 Protein kinases ATP-binding region FT signature" FT CDS 64343..64747 FT /transl_table=11 FT /gene="ML0898" FT /product="putative DNA-binding protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative transcriptional regulator TR:O69567 FT (EMBL:AL022602) (134 aa); Fasta score E(): 0, 99.3% FT identity in 134 aa overlap(EMBL:AL022602). Also highly FT similar to Mycobacterium tuberculosis hypothetical protein FT TR:O5350 (EMBL:AL021957) (146 aa); Fasta score E(): 0, FT 82.1% identity in 134 aa overlap(EMBL:AL021957). Contains a FT probable helix-turn-helix motif at aa 18-39 (Score 1581, SD FT +4.57)" FT /db_xref="GOA:O69567" FT /db_xref="UniProtKB/TrEMBL:O69567" FT /protein_id="CAC31279.1" FT /translation="MGSIPAGDDVLDPDEPTYDLTQVAELLGIPVSRVHRKLCEGYLVA FT VRRGDSLVVPQIFFTNSGAVVKSLPGLLTILHDGSFHETEIVRWLFTPDPSLTLTRDGS FT RDVVSNARPVDALHTHQAREVVRRAQAMAY" FT CDS complement(64744..66261) FT /transl_table=11 FT /gene="ML0899" FT /product="probable integral-membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative integral membrane protein TR:O69566 FT (EMBL:AL022602) (505 aa); Fasta score E(): 0, 100.0% FT identity in 505 aa overlap(EMBL:AL022602). Also highly FT similar to Mycobacterium tuberculosis putative membrane FT protein TR:O53508 (EMBL:AL021957) (516 aa); Fasta score FT E(): 0, 78.9% identity in 502 aa overlap(EMBL:AL021957). FT Contains multiple possible membrane spanning hydrophobic FT domains." FT /db_xref="InterPro:IPR017822" FT /db_xref="UniProtKB/TrEMBL:O69566" FT /protein_id="CAC31280.1" FT /translation="MTTPTHLPEANSPTKRYIHQYFSQLRMFAASPESGPAKLGLLGSL FT LITTGGLGAGSIRQHDPLLELICMSWLRFGHGLVLSSILLWTGVSLMLIAWLRLGRRVL FT AGQATEFMMRATIGFWLTPLLLSVPVFSRDTYSYLAQGALLRDGLDPYLVGPVGNPNAL FT LDNVSPIWTITTAPYGPAFILVAKFVTLAVGNNVVTGTMLLRLCMLPGLALLIWATPRL FT AQHFGADGTTALWTCVLNPLVLIHLMGGVHNEMLMVGLMTAGVALTFQGRNVAGTALIT FT VAIAVKATAGISLPFMVWVWMRQLHNRRGYRPVQAFLAATATALLIFATVFAVLSTAAS FT VGLGWMTALAGSVKIINWLTVPTAIANLVNVLANGFFATDFYGVLRMTRFIGIVIIAVS FT LPLLWWRYRRDDRSALTGIAWSMLIVVLFVPAALPWYYSWPLAVAAPLAQSRQALATIA FT GFSSWIMVIFKPDGSHGMYSWLHFSLATTCALIAWHALYKAPETDTA" FT CDS complement(66278..67324) FT /pseudo FT /transl_table=11 FT /gene="idsA2" FT /gene_synonym="ML0900" FT /product="geranylgeranyl pyrophosphate synthase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT idsA2 (Best blastx score 561)" FT misc_feature complement(66608..66646) FT /note="PS00444 Polyprenyl synthetases signature 2" FT RBS 67591..67595 FT CDS 67600..68514 FT /transl_table=11 FT /gene="ML0901" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 FT aa); Fasta score E(): 0, 99.7% identity in 304 aa FT overlap(EMBL:AL022602). Also highly similar to FT Mycobacterium tuberculosis hypothetical protein TR:O53506 FT (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% FT identity in 299 aa overlap(EMBL:AL021957)." FT /db_xref="UniProtKB/TrEMBL:O69565" FT /protein_id="CAC31282.1" FT /translation="MTLNTIALELVPPNLDAGQERAVEDACKVVQYSAESGLSGRIRHV FT MIPGMIVEEDDRPIPMKPKLDVLDFWSIVRPELPGVNGLCTQVTAFMDEASLGRRLADL FT SAAGMEGVVFVGVPRTMNDGEGSGVAPTDALSMYRELVANRGVIVIPTRDGEQDRLNFK FT CNQGATYGMTQLLYSDAIVRFLTEFAKHTDHRPELLLSFGFVPKAERRVGLINWLIQDS FT GNAAVADEQEFVKRLAGSEPAQKRQLMLDLYQRVIDGVAELGFPLSIHFEATYGMSPAA FT FDTFAEMVAYWPPVCVGQSGEST" FT CDS complement(68511..69230) FT /transl_table=11 FT /gene="ML0902" FT /product="probable lipoprotein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative lipoprotein TR:O69564 (EMBL:AL022602) (239 FT aa); Fasta score E(): 0, 99.6% identity in 239 aa FT overlap(EMBL:AL022602) and also highly similar to another FT putative lipoprotein from Mycobacterium tuberculosis FT TR:O53505 (EMBL:AL021957) (227 aa); Fasta score E(): 0, FT 75.4% identity in 224 aa overlap(EMBL:AL021957). Contains a FT possible N-terminal signal sequence. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="UniProtKB/TrEMBL:O69564" FT /protein_id="CAC31283.1" FT /translation="MRARFPPLFTRGCTAQRRRTLTIALLLVAMVPLATGCLRVTASIT FT ISPDNLVSGKIIAAAKPKNKNDAGPQLNDNLPFSQKIAVSNYNSDGYVGSQAVFSDLTF FT AELPQLANMNSSTTDVTLSLRRNGNLVILESRADLTSVTDPDADVELTVAFPGVVTSTN FT GDRIETKVVAWKLKPGVVSTMSARARYTDPDTRSFTGAAVWLGIASFSAASVVVLLAWN FT ERKSSARLQIPRDSSSS" FT misc_feature complement(69120..69152) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(69302..69934) FT /transl_table=11 FT /gene="ML0903" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O69563 (EMBL:AL022602) (210 FT aa); Fasta score E(): 0, 99.5% identity in 210 aa FT overlap(EMBL:AL022602). Also highly similar to another FT protein of undefined function from Mycobacterium FT tuberculosis TR:O53504 (EMBL:AL021957) (206 aa); Fasta FT score E(): 0, 76.7% identity in 210 aa FT overlap(EMBL:AL021957)." FT /db_xref="GOA:O69563" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:O69563" FT /protein_id="CAC31284.1" FT /translation="MAIFLINLSPNEMERRLNEALEVYVDAMRYPRNTENLRAGIWLEH FT IRRPGWQAVAAVEVRIEVADVADMADGPAHPAPSADELNNAPLRGVAYGYPGAPGQWWQ FT QQVVQGLQRSGLSTLEIARLMNSYFELTELHIHPHTQGRGIGEALTRRLLAHRRENNVL FT LSTPETNGETNRAWRLYRRLGFMDIIRRHYFAGDPRAFAILGRTLPL" FT RBS complement(69945..69950) FT RBS 70241..70245 FT CDS 70251..70655 FT /transl_table=11 FT /gene="ML0904" FT /product="probable membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O69562 (EMBL:AL022602) (134 FT aa); Fasta score E(): 0, 100.0% identity in 134 aa FT overlap(EMBL:AL022602). Also highly similar to several FT others e.g. Mycobacterium tuberculosis hypothetical protein FT TR:O53503 (EMBL:AL021957) (134 aa); Fasta score E(): 0, FT 86.6% identity in 134 aa overlap(EMBL:AL021957) and FT Streptomyces coelicolor putative membrane protein TR:Q9XAJ8 FT (EMBL:AL079348) (96 aa); Fasta score E(): 0.22, 38.3% FT identity in 60 aa overlap(EMBL:AL079348). Contains a large FT central possible membrane spanning hydrophobic domain." FT /db_xref="UniProtKB/TrEMBL:O69562" FT /protein_id="CAC31285.1" FT /translation="MPLSDHEQRMLDQIESALYAEDPKFVSSVRGGGLRVPTARRRTQG FT AALFVIGLGMLVCGVAFKATMIGSFPILSVFGFVVMFGGVLFAITGSRLSGREDHPGLA FT PGTSRQRRSKGAAGSFTSRMEDRFRRRFDE" FT RBS 71016..71021 FT CDS 71028..71459 FT /transl_table=11 FT /gene="ML0905" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein SW:YL66_MYCLE (SW:O69561) (143 FT aa); Fasta score E(): 0, 99.3% identity in 143 aa FT overlap(SW:O69561). Also highly similar to many other FT proteins of undefined function including: Mycobacterium FT tuberculosis SW:YL66_MYCTU (SW:O06211) (143 aa); Fasta FT score E(): 0, 92.3% identity in 142 aa overlap(SW:O06211) FT and Escherichia coli SW:YABB_ECOLI (SW:P22186) (152 aa); FT Fasta score E(): 3.8e-11, 32.0% identity in 147 aa FT overlap(SW:P22186)." FT /db_xref="InterPro:IPR003444" FT /db_xref="UniProtKB/Swiss-Prot:O69561" FT /protein_id="CAC31286.1" FT /translation="MFLGTHTPKLDDKGRLTLPAKFRDALVGGLMVTKSQDHSLAVYPR FT AEFEQLARRASKMSRSNPEARAFLRNLAAGTDEQHPDMQGRITLSADHRRYANLSKDCV FT VIGAVDYLEIWDAQAWHDYQQTHEENFSAASDEALGDII" FT CDS 71587..72705 FT /transl_table=11 FT /gene="ML0906" FT /product="conserved hypothetical protein" FT /note="Identical over 340 aa to the previously sequenced FT Mycobacterium leprae hypothetical protein SW:YL65_MYCLE FT (SW:O69560) (340 aa); Fasta score E(): 0, 99.7% identity in FT 340 aa overlap(SW:O69560). Also highly similar to many FT other proteins of undefined function including: FT Mycobacterium tuberculosis TR:O06212 (EMBL:Z95388) (396 FT aa); Fasta score E(): 0, 74.2% identity in 376 aa FT overlap(EMBL:Z95388) and Escherichia coli SW:YABC_ECOLI FT (SW:P18595) (313 aa); Fasta score E(): 0, 41.6% identity in FT 298 aa overlap(SW:P18595). Contains Pfam match to entry FT PF01795 DUF36, Domain of unknown function." FT /db_xref="GOA:O69560" FT /db_xref="HSSP:1M6Y" FT /db_xref="InterPro:IPR002903" FT /db_xref="UniProtKB/Swiss-Prot:O69560" FT /protein_id="CAC31287.1" FT /translation="MPSDRDHDAGIFAFFGAVPRSDRCRQTRGGGEVVDGSSVFGHVPV FT FAQRCVTLLAPALTRHHADGSNAILVDATLGVGGHAERFLTEFPGLRLIGLDRDPSALD FT IARTRLMRFADRVTLIHTRYDNLAVALNKFGYAAVESVDGVLFDLGVSSMQLDCAERGF FT SYAQDVPLDMRMDPWSPVSAADIVNNYDEAALADILRRYGEERFARRIAAHIVRRRAHT FT PFTSTAELVALLYQAIPAPARRIGGHPAKRTFQALRIAVNDELNSLSNVLPAALDALTV FT AGRLVVLAYQSLEDRIVKRVFADAVSSRTPAGLPIELPGHGPRFRLLTRGAEHADAAEI FT ECNPRSAAVRLRALQRTQHGVEPQQPTRRGDS" FT misc_feature 71704..72657 FT /note="Pfam match to entry PF01795 DUF36, Domain of unknown FT function, score 560.70, E-value 9.8e-165" FT RBS 72688..72693 FT CDS 72702..73835 FT /transl_table=11 FT /gene="ML0907" FT /product="putative conserved membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O69559 (EMBL:AL022602) (377 FT aa); Fasta score E(): 0, 100.0% identity in 377 aa FT overlap(EMBL:AL022602). Also highly similar to FT Mycobacterium tuberculosis TR:O06213 (EMBL:Z95388) (384 FT aa); Fasta score E(): 0, 62.2% identity in 397 aa FT overlap(EMBL:Z95388). Contains a possible membrane spanning FT hydrophobic domain and a possible coiled-coil between FT residues 155..168." FT /db_xref="UniProtKB/TrEMBL:O69559" FT /protein_id="CAC31288.1" FT /translation="MKAQRDTPIRRGDSGRPGGRDGAARSGKRTANEAGSRRLRTHAGK FT ISASAREVGVPKSGPRTSPMSRPVERPARPRNTTQAKARAKARKAKAPKVVRPRLGECL FT IARLALIDLRPRTLVNKVPFVVLVISSLGVGLGLTLWLSTDSAERSYQLGDAREQARML FT QQQKEALERDVREAESAPALAETARKQGMIPTRDTAHLVQGPGGNWVVVGTPKPADGVP FT PPPLNTKLPDAGPPSLKPPEIPLEVPVRVVPGPGGPPPPARSGPQMWLRVPDGATTLGG FT QHLPQELPQLPGMLNGPAAAQVQVPGFMPTPGLPIPGSTMRVPVPAPAPTEVPVRLQPG FT LVSPAVTSPVISTSPVPTPVNSEQFGPVTATAPGTSR" FT CDS 73832..75859 FT /transl_table=11 FT /gene="pbpB" FT /gene_synonym="ML0908" FT /product="penicillin-binding protein 2" FT /note="Identical to the previously sequenced Mycobacterium FT leprae penicillin binding protein 2 TR:O69558 FT (EMBL:AL022602) (675 aa); Fasta score E(): 0, 99.9% FT identity in 675 aa overlap(EMBL:AL022602). Also highly FT similar to Mycobacterium tuberculosis hypothetical protein FT TR:O06214 (EMBL:Z95388) (679 aa); Fasta score E(): 0, 80.6% FT identity in 677 aa overlap(EMBL:Z95388) and to many other FT penicillin-binding proteins e.g. Neisseria meningitidis FT SW:PBP2_NEIME (P11882) (581 aa); Fasta score E(): 4.3e-29, FT 32.4% identity in 590 aa overlap(P11882). Contains Pfam FT match to entry PF00905 Transpeptidase, Penicillin binding FT protein transpeptidase domain. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:O69558" FT /db_xref="HSSP:1QME" FT /db_xref="InterPro:IPR005311" FT /db_xref="UniProtKB/TrEMBL:O69558" FT /protein_id="CAC31289.1" FT /translation="MRRGDAHRPCSSRSAQLGNSSSTPPVRQPKRLRQPEKARKAKDTK FT KSRSAVAADAVTEGRSARKRRTRQVVEIGTYGPSFIFRHRGGNVVIFALMLVAATQLFN FT LQVSNAAGLRAQAAGQLRVTDVEKAVRGSITDRNNEQLAFTIESRALTFQPKKIRQQLE FT EAKQKTPSAPDPQQRLQDIAKEVAGRLSNKPDGPSLLKKLQSNDSFVYLARAVDPAVAE FT AISAKYPEVGSERQDLRQYPGGSLAANIVGGIDWDGHGLLGLEDSLDSVLSGTDGSVTY FT DRGSDGVVIPGSYRNRHRAVNGSTVQLTIDDDIQFYVQQQVQQAKNLSGAHNVSAVVLD FT AKTGEVLAMANDNTFDPSQDIGRQGGKQLGNLAVSSPFEPGSVNKVITASAVIEYGLST FT PDEVLQVPGSIQMGGVSVHDAWEHGVMPYTTTGVFGKSSNVGTLMLAQRVGPERFYDMV FT RKFGLGQLTGVGLPGESEGLVPSVDQWSGSTFSNLPIGQGLSTTLLQMTGMYQVIANDG FT VRIPPRIIKATNAADGTRTQEPRPDGIRVVSPQTAQTVRQMLRAVVQKDPMGYQQGTGP FT AAGVSGYQIAGKTGTAQQVNPACRCYFDDVYWITFAGMATVDNPRYVIGTMMDNPERNA FT DGTPGHSAAPLFHNVAGWLMQRENVPLSPDPGPPLTLQAT" FT misc_feature 74765..75778 FT /note="Pfam match to entry PF00905 Transpeptidase, FT Penicillin binding protein transpeptidase domain, score FT 417.90, E-value 9.6e-122" FT misc_feature 75575..75598 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT RBS 75995..76001 FT CDS 76001..77593 FT /transl_table=11 FT /gene="murE" FT /gene_synonym="ML0909" FT /product="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diami FT nopime ligase (meso-diaminopimelate-adding enzyme)." FT /note="Identical to the previously sequenced Mycobacterium FT leprae FT UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate FT ligase (EC 6.3.2.13) SW:MURE_MYCLE (AL022602) (530 aa); FT Fasta score E(): 0, 99.8% identity in 530 aa overlap. Also FT highly similar to MurE orthologues from Mycobacterium FT tuberculosis SW:MURE_MYCTU (O06219) (535 aa); Fasta score FT E(): 0, 74.4% identity in 519 aa overlap and Escherichia FT coli SW:MURE_ECOLI (P22188) (494 aa); Fasta score E(): 0, FT 39.1% identity in 493 aa overlap. Contains Pfam match to FT entry PF01225 Mur_ligase, Mur ligase family." FT /db_xref="GOA:O69557" FT /db_xref="HSSP:1E8C" FT /db_xref="InterPro:IPR005761" FT /db_xref="UniProtKB/Swiss-Prot:O69557" FT /protein_id="CAC31290.1" FT /translation="MTEVVAVPVRLRPSATAGVRLPELVAQVGAVLADGPGQAATVPDI FT PVTGVTLRAQEVLSGDLFAALAGASTHGARYAGVALERGAVAVLTDVAGVAELTAQASS FT VPILIHPEPRSVLGGLAAAAYGHPSNRMTVVGITGTSGKTTTTYMVEAGLRAGGRVVGL FT VGTIGIRIDGADIPSFLTTPEAPALQAMLAAMVERGVETVVMEVSSHALSLGRVEGTQF FT AVAGFTNLSRDHLDFHPDMEEYFEAKAVLFDPHSLLRARTVVVCIDDDAGRATAARAGD FT AITVSALGQPASWRATDIRSPGVGAQEFTAVDPAGVQHRVGIRLPGRYNVANCLVALAI FT LDVVGVSPEQASLGFRDIRIPGRLERIDCGQDFLALVDYAHKPGALHSVLTALLQPDHR FT LAVVFGAGGERDPGKRAPMGEIAAELADLVVVTDDNPRGEDPAAIRRDILTGTVAAGGA FT AQVVEIGDRRAAIQYAVAWAGPDDVVLVAGKGHETGQRGAAETCPFDDRVELARALQVR FT DARLLPAPGRACQ" FT misc_feature 76400..77149 FT /note="Pfam match to entry PF01225 Mur_ligase, Mur ligase FT family, score 297.90, E-value 1.3e-85" FT CDS 77590..79143 FT /transl_table=11 FT /gene="murF" FT /gene_synonym="ML0910" FT /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl FT ligase (D-alanine:D-alanine-adding enzyme)" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein FT UDP-N-acetylmuramoylalanyl-D-glutamyl FT -2,6-diaminopimelate--D-alanyl-D-alanyl ligase TR:O69556 FT (EMBL:AL022602) (517 aa); Fasta score E(): 0, 100.0% FT identity in 517 aa overlap(EMBL:AL022602). Also highly FT similar to MurF orthologues from Mycobacterium tuberculosis FT SW:MURF_MYCTU (SW:O06220) (510 aa); Fasta score E(): 0, FT 75.5% identity in 531 aa overlap(SW:O06220) and Escherichia FT coli SW:MURF_ECOLI (SW:P11880) (452 aa); Fasta score E(): FT 1.7e-09, 31.0% identity in 519 aa overlap(SW:P11880). FT Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase FT family." FT /db_xref="GOA:O69556" FT /db_xref="HSSP:1GG4" FT /db_xref="InterPro:IPR005863" FT /db_xref="UniProtKB/Swiss-Prot:O69556" FT /protein_id="CAC31291.1" FT /translation="MIDLTVARVTEIVGGALVDISPEEAAERRVTGSVEFDSRAVGPGG FT LFLALPGARSDGHDHAASAIAAGAVAVLAARPVGVPAIVVAPDPRTGDGGLTGVLEHDA FT DGSGAAVLAALAKLAKAVAAELVAGGLTIIGITGSSGKTSTKDLVAVVLELLGEVVAPP FT ESFNNELGHPWTVLRATRSTDYLILEMSARRPGNIAALAAIAPPKIGVVLNVGTAHLGE FT FGSREAIARTKTELPQAIMQSGVVILNVDDPAVAAMADATVARVIRVSRGSYSHPGSPN FT SPDVWTGPVSLDELARPRFTLHTRDPRAGATEIQLGVYGDHQVANALCAAAVGLECGAS FT VEEVAVALAATGPVSRHRMQVTTRADGVTVIDDTYNANPDSMRAGLQALAWIAHGGTHD FT KNQPGSCARRSWAVLGEMAELGEDSITEHDRIGRLAVRLDVSRLVVVGGGRSINAMHRG FT AVMEGSWGLETVNVADPAAALTLLRAEVRPGDVVLIKASHSVGLGALADVLVGDGAIRP FT " FT misc_feature 77986..78726 FT /note="Pfam match to entry PF01225 Mur_ligase, Mur ligase FT family, score 267.70, E-value 1.6e-76" FT CDS 79140..80219 FT /transl_table=11 FT /gene="mraY" FT /gene_synonym="ML0911" FT /product="phospho-N-acetylmuramoyl-pentapeptidetransferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae phospho-N-acetylmuramoyl-pentapeptide-transferase FT (EC 2.7.8.13) SW:MRAY_MYCLE (SW:O69555) (359 aa); Fasta FT score E(): 0, 100.0% identity in 359 aa overlap(SW:O69555). FT Also highly similar to FT phospho-N-acetylmuramoyl-pentapeptide-transferases from FT Mycobacterium tuberculosis SW:MRAY_MYCTU (SW:O06221) (359 FT aa); Fasta score E(): 0, 91.1% identity in 359 aa FT overlap(SW:O06221) and Escherichia coli SW:MRAY_ECOLI FT (SW:P15876) (360 aa); Fasta score E(): 6.2e-29, 35.9% FT identity in 343 aa overlap(SW:P15876). Contains multiple FT possible membrane spanning hydrophobic domains and a FT possible N-terminal signal sequence. Contains Pfam match to FT entry PF00953 Glycos_transf_4, Glycosyl transferase." FT /db_xref="GOA:O69555" FT /db_xref="InterPro:IPR018480" FT /db_xref="UniProtKB/Swiss-Prot:O69555" FT /protein_id="CAC31292.1" FT /translation="MRQILVAVTVALVVSILLTPALIRLFTRHGFGQEIREDGPPSHHN FT KRGTPSMGGVAIVAGIWAGYLGTHLAGLAFDGEGVSASGVLVLGLATALGGVGFLDDLI FT KIRRSRNLGLNKTAKTVGQITAAVLFGVLVLQFRNGAGLTPASADLSYVREIATVTLAP FT ALFVLFCMVIVSAWSNAVNFTDGLDGLAAGSMAMVTAAYVLITFWQYRNACVTAPGLGC FT YNVRDPLDLTLIAAATVGACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEIL FT AVVLGSLFVAEITSVVLQILAFRTTGRRVFRMAPFHHHFELAGWAETTVIIRFWLLTAI FT ACGLGVVLFYGEWLATIGA" FT misc_feature 79389..79985 FT /note="Pfam match to entry PF00953 Glycos_transf_4, FT Glycosyl transferase, score 274.30, E-value 1.6e-78" FT CDS 80221..81693 FT /transl_table=11 FT /gene="murD" FT /gene_synonym="ML0912" FT /product="UDP-N-acetylmuramoylalanine-D-glutamate ligase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae UDP-N-acetylmuramoylalanine-D-glutamate ligase FT TR:O69554 (EMBL:AL022602) (490 aa); Fasta score E(): 0, FT 99.8% identity in 490 aa overlap(EMBL:AL022602). Also FT highly similar to orthologues from Mycobacterium FT tuberculosis SW:MURD_MYCTU (SW:O06222) (486 aa); Fasta FT score E(): 0, 75.9% identity in 493 aa overlap(SW:O06222) FT and Bacillus subtilis SW:MURD_BACSU (SW:Q03522) (451 aa); FT Fasta score E(): 7.1e-24, 28.4% identity in 493 aa FT overlap(SW:Q03522). Contains Pfam match to entry PF01225 FT Mur_ligase, Mur ligase family." FT /db_xref="GOA:P57995" FT /db_xref="HSSP:2UAG" FT /db_xref="InterPro:IPR005762" FT /db_xref="UniProtKB/Swiss-Prot:P57995" FT /protein_id="CAC31293.1" FT /translation="MLDTLVPGAPVLVAGGGVTGRAVLAALTRFGMAATLCDDDPAALQ FT QYADNGVATVSAATATQQMFERGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELA FT WRLDAAGYYGPPRRWLVVTGTNGKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEF FT AEPSDFLAVELSSFQLHWAPSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVA FT VVGLDDSRAAALLSTTVAPVRVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIP FT VSGPVGVLDALAAAALARSVGVGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKAT FT NPHAALVSVLAYPRVVWVAGGLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRH FT APNVPVVQVVAGEDAGMHAVAVVSGTDVISISDVGGTIGTRVMVAAVAAARDLAQPGDT FT VLLAPAGASFDQFSGYADRGDTFATAVRAAIR" FT misc_feature 80575..81243 FT /note="Pfam match to entry PF01225 Mur_ligase, Mur ligase FT family, score 251.30, E-value 1.3e-71" FT RBS 81692..81696 FT CDS 81700..83304 FT /transl_table=11 FT /gene="ftsW" FT /gene_synonym="ML0913" FT /product="putative cell division protein FtsW" FT /note="Identical to the previously sequenced Mycobacterium FT leprae cell division protein, FtsW, TR:O69553 FT (EMBL:AL022602) (534 aa); Fasta score E(): 0, 99.8% FT identity in 534 aa overlap(EMBL:AL022602). Also highly FT similar many other FtsW-family proteins involved in cell FT wall formation e.g. from Mycobacterium tuberculosis FT FtsW-like protein SW:FTWH_MYCTU (SW:O06223) (524 aa); Fasta FT score E(): 0, 76.5% identity in 528 aa overlap(SW:O06223) FT and Escherichia coli FtsW SW:FTSW_ECOLI (SW:P16457) (414 FT aa); Fasta score E(): 3.6e-31, 37.0% identity in 370 aa FT overlap(SW:P16457). Contains multiple possible membrane FT spanning hydrophobic domains. Contains Pfam match to entry FT PF01098 FTSW_RODA_SPOVE, Cell cycle protein. Contains FT PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. FT Contains PS00041 Bacterial regulatory proteins, araC family FT signature." FT /db_xref="GOA:O69553" FT /db_xref="InterPro:IPR013437" FT /db_xref="UniProtKB/TrEMBL:O69553" FT /protein_id="CAC31294.1" FT /translation="MGNALGRDRGRGTGDNNSVQAATTVEAVEPGTATTGEVSEAEAKR FT AGSLRAGVRGPQTRFDAWLGRPMASFHLIIAVAGLLTALGLIMVLSASGVRSYGDDGSA FT WIIFGKQVLWTIIGLIGGYSSLWMSIRFIRRIAFFSYVITIILLVLVLIPGIGNLANGS FT RKWFVIAGFSMQPSELAKIAFVIWGAHLLAARRMERASLREMLIPLVPAAVIALGLIVA FT QPDLGQTVSLGIILLALLWYAGLPLRVFITSLLAVFIAGAILAMSAGYRSERVRSWMNP FT EADPQDTGYQARQAKFALAHGGIFGDGLGQGVAKWNYLPNAHNDFIFAIIGEELGLVGA FT LGLLGLFGLFAYTGMRIARRSADPFLRLLTATTTMWVLGQAFINIGYVIGVLPVTGLQL FT PFISAGGTSAAAILFMIGIMANAARHEPEAVAALRAGRDDKVNQLLRLPLPVPYLPPRV FT ETFRDRKQVRPQPGKASVGRKPARKAPREPDRPLRPAFPRVADRLEHRSGQYRAGQLRA FT GQRYTPRVRVFEGQRYG" FT misc_feature 81910..82983 FT /note="Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell FT cycle protein, score 564.50, E-value 7e-166" FT misc_feature 82798..82926 FT /note="PS00041 Bacterial regulatory proteins, araC family FT signature" FT misc_feature 82849..82923 FT /note="PS00428 Cell cycle proteins ftsW / rodA / spoVE FT signature" FT CDS 83301..84524 FT /transl_table=11 FT /gene="murG" FT /gene_synonym="ML0914" FT /product="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentape FT pt pyrophosphoryl-undecaprenol N-acetylglucosamine FT transferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae FT UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) FT pyrophosphoryl-undecaprenol N-acetylglucosamine transferase FT (EC 2.4.1.-) SW:MURG_MYCLE (SW:O69552) (407 aa); Fasta FT score E(): 0, 99.8% identity in 407 aa overlap(SW:O69552). FT Also highly similar to orthologues from Mycobacterium FT tuberculosis SW:MURG_MYCTU (SW:O06224) (410 aa); Fasta FT score E(): 0, 76.3% identity in 401 aa overlap(SW:O06224) FT and Escherichia coli SW:MURG_ECOLI (SW:P17443) (354 aa); FT Fasta score E(): 4.2e-21, 38.1% identity in 365 aa FT overlap(SW:P17443). Contains a possible membrane spanning FT hydrophobic domain." FT /db_xref="GOA:O69552" FT /db_xref="HSSP:1F0K" FT /db_xref="InterPro:IPR006009" FT /db_xref="UniProtKB/Swiss-Prot:O69552" FT /protein_id="CAC31295.1" FT /translation="MNNSVREPTRGRRGSPPVADAALSVNPPLSVVLAGGGTAGHVEPA FT MAVADALRALDPQVRITALGTSRGLETRLVPERGYHLELITPVPLPRKLTGDLARLPLR FT VWRAVRETRAVFEVVEAHVVVGFGGYVALPAYLAARGIPRVRRRIPVVVHEANARAGIA FT NRVGVRTAERVLSAVPGSGLRGAEVVGVPIHATITTLNRPALRADARKHFGFTDDARVL FT LVFGGSQGAVSLNRAVAGAAEDLAASGVAVLHAYGLKNTLELRTPEYGEPPYVAVPYLD FT RMDLAYAAADLVICRSGAMTVAEVSAVGLPAIYVPFPIGNGEQRLNALPVVNAGGGLVV FT ADADLTPGLVARQVVRLFSDPAQLAAMTAAAARVGHRDAAHHVAKVALDLARAERDTAS FT GRSAGGKP" FT RBS 84510..84514 FT CDS 84521..86008 FT /transl_table=11 FT /gene="murC" FT /gene_synonym="ML0915" FT /product="UDP-N-acetyl-muramate-alanine ligase" FT /note="Identical, over available sequence, to the FT previously sequenced Mycobacterium leprae FT UDP-N-acetylmuramate-alanine ligase (fragment) TR:O69551 FT (EMBL:AL022602) (235 aa); Fasta score E(): 0, 99.6% FT identity in 235 aa overlap(EMBL:AL022602). Also highly FT similar to UDP-N-acetylmuramate-alanine ligases from FT Mycobacterium tuberculosis SW:MURC_MYCTU (SW:O06225) (494 FT aa); Fasta score E(): 0, 79.8% identity in 494 aa FT overlap(SW:O06225) and Escherichia coli SW:MURC_ECOLI FT (SW:P17952) (491 aa); Fasta score E(): 0, 35.2% identity in FT 477 aa overlap(SW:P17952). Contains Pfam match to entry FT PF01225 Mur_ligase, Mur ligase family." FT /db_xref="GOA:P57994" FT /db_xref="HSSP:1GQY" FT /db_xref="InterPro:IPR004101" FT /db_xref="UniProtKB/Swiss-Prot:P57994" FT /protein_id="CAC31296.1" FT /translation="MNAGQLPPELQRVHMVGIGGSGMSGIARILLDRGGLVSGSDAKES FT RVVHALRARGALIRIGHDASLLDLLPGGATAVITIRTAIPKTNPELVEARRRGIPVLLR FT SAVLARLMDGCTTLMVAGTHGKTTTTSMLVVALQHCGCDPSFVVGGELAVVGTNAHHGL FT GACFVAEADESDGSLLEYTPNVAVVTNIDSDHLDFYGSVDAYIRVFDSFVERFALGGAL FT VVCNDDPGAAALARRTAELGIRVLRYGSDDRIGETLAARLLSWEQQGTGAVAHIQLAGQ FT PNSRVMRLPVPGRHMALNALGALLAAIEIGASTDEVLDGLAGFRGVRRRFELVGTSGVG FT QASNSLVRVFDDYAHHPTEISATLAAFRIMLEQSGGGRCIVVFQPHLYSRTKALSREFG FT RALSAADEVFIVGVNGAREQPLAGVSGASVAKHVSVPVRYIPDYSAVVIEVAAAAGPGD FT VIVTMGIGDVGLLGPEIVAALRVRANCNTPGCSGVLQ" FT misc_feature 84869..85591 FT /note="Pfam match to entry PF01225 Mur_ligase, Mur ligase FT family, score 213.20, E-value 3.8e-60" FT RBS 85994..85997 FT CDS 86005..87030 FT /transl_table=11 FT /gene="ML0916" FT /product="putative FtsQ-family protein" FT /note="Similar to many FtsQ-family proteins thought to be FT involved in septum formation e.g. Mycobacterium FT tuberculosis SW:FTSQ_MYCTU (SW:O06226) (314 aa); Fasta FT score E(): 0, 75.4% identity in 297 aa overlap(SW:O06226) FT and in parts to Corynebacterium glutamicum SW:FTSQ_CORGL FT (SW:O24745) (222 aa); Fasta score E(): 2.3e-13, 26.6% FT identity in 203 aa overlap(SW:O24745). Contains a possible FT membrane spanning hydrophobic domain." FT /db_xref="InterPro:IPR013685" FT /db_xref="UniProtKB/TrEMBL:Q9CCE5" FT /protein_id="CAC31297.1" FT /translation="MTETDEGAPVNHSATMWAVVGVPPVCGGQPGDSGVVAGTSRALVD FT AAIIAPVTTLTRDEPAQYDRYEFEGPRRRARRERAERRAAQACAIAIEEARREAKHRIH FT RQMSSEANSPKPVARGVVRGLKTLFATVMFSIAGFGLGLALYVTPAMSVRNIVVTGIET FT VTREEVLDAAGVQLGTPLLQINTNQVADQVAAIRRVASARAQRQYPSALRITIVERVPV FT VVKDFPDGPHLFDCDGVDFATAPPPPALPYIDVGHPGPIDPATKAALVVLLALRPEVVS FT QVARIAAPSVSSITLILTDGRAVIWGSTDRAEEKAEKLAALLTQPGRTYDVSSPDLPTV FT K" FT RBS 87281..87285 FT CDS 87296..88435 FT /transl_table=11 FT /gene="ftsZ" FT /gene_synonym="ML0917" FT /product="cell division protein" FT /note="Highly similar to many proteins essential for cell FT division including: Mycobacterium tuberculosis FT SW:FTSZ_MYCTU (O08378) (379 aa); Fasta score E(): 0, 96.6% FT identity in 379 aa overlap and Streptomyces griseus FT SW:FTSZ_STRGR (P45501) (407 aa); Fasta score E(): 0, 68.7% FT identity in 390 aa overlap. Contains Pfam match to entry FT PF00091 tubulin, Tubulin/FtsZ family. Contains PS01134 FtsZ FT protein signature 1. Contains PS01135 FtsZ protein FT signature 2." FT /db_xref="GOA:Q9CCE4" FT /db_xref="HSSP:1OFU" FT /db_xref="InterPro:IPR003008" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCE4" FT /protein_id="CAC31298.1" FT /translation="MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFMAINTDAQ FT ALLMSDADVKLDVGRDSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGG FT GTGTGGAPVIASIARKLGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPN FT DRLLQMGDTAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTAL FT MGIGSARGDGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQD FT AAHPDANIIFGTVIDDSLGDEVRVTVIAAGFEANGPGRTPVMGSTGGAHRIESAKAGAL FT TSTLFEPVDAASAPLHTNGAALSIGGDDDDVDVPPFMRR" FT misc_feature 87416..87520 FT /note="PS01134 FtsZ protein signature 1" FT misc_feature 87467..87928 FT /note="Pfam match to entry PF00091 tubulin, Tubulin/FtsZ FT family, score 62.60, E-value 3.5e-15" FT misc_feature 87575..87640 FT /note="PS01135 FtsZ protein signature 2" FT CDS 88458..89207 FT /transl_table=11 FT /gene="ML0918" FT /product="conserved hypothetical protein" FT /note="Similar to many proteins of unknown function FT including: Mycobacterium tuberculosis TR:O06227 FT (EMBL:Z95388) (250 aa); Fasta score E(): 0, 60.2% identity FT in 244 aa overlap and Streptomyces griseus SW:YFIH_STRGR FT (P45496) (246 aa); Fasta score E(): 5.8e-21, 38.0% identity FT in 245 aa overlap. Note bothe of htese examples are also FT found downstream of FtsZ." FT /db_xref="InterPro:IPR003730" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCE3" FT /protein_id="CAC31299.1" FT /translation="MGGFADTGQVSVRIRWVITMRAGGVLVSPFDFLDLGDHVGDDPDC FT GGHLSRAWLVAAIGLGVDRVVWMSQVHGDRVKVVHEPCDAVVDNTDALVTRTSQPALPV FT VTIHCVPVLLSDARPGVTAAVHVGEGRGSARCASPCDGYDAGPGCVRWRRDIAVLLGPA FT VSGRNYEVPVVIADGVEAASPDSCTTTRISAGTPGLDLRTGIACQFRDLGVMSIEDDPR FT RTVADRALFSHLQTVSTGRLASLVWME" FT CDS 89204..89986 FT /transl_table=11 FT /gene="ML0919" FT /product="possible DNA-binding protein" FT /note="Similar to many proteins of unknown function FT including: Mycobacterium tuberculosis SW:YL48_MYCTU FT (O06228) (258 aa); Fasta score E(): 0, 73.6% identity in FT 258 aa overlap and Corynebacterium glutamicum SW:YFZ1_CORGL FT (O24748) (221 aa); Fasta score E(): 7e-22, 41.6% identity FT in 231 aa overlap. Contains a probable helix-turn-helix FT motif at aa 78-99 (Score 1061, SD +2.80) Contains Pfam FT match to entry PF01168 UPF0001, Uncharacterized protein FT family UPF0001. Contains PS01211 Uncharacterized protein FT family UPF0001 signature." FT /db_xref="HSSP:1B54" FT /db_xref="InterPro:IPR011078" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCE2" FT /protein_id="CAC31300.1" FT /translation="MTAMAADIDLQGDRESELMHALATVRSRLAAASQAAGRNVGEIEL FT LPISKFFPATDVAILSRLGCRSVGESRAQEASTKAAEFAELLGVSREEKSSIHWHMVGQ FT IQRNKVRSLAQWAHTAHSIDSLQLVAALDRAVAAALAGGRREQPLQVYVQISLDGDISR FT GGVNVTAPGAVDRVCAQVEESKSLELVGLMGIPPLGWNPDQAFEQLRLEHRRVLRSHPD FT AIGLSAGMSNDFEIAVKHGSTCVRVGTALLGPSRLRSP" FT misc_feature 89261..89974 FT /note="Pfam match to entry PF01168 UPF0001, Uncharacterized FT protein family UPF0001, score 84.00, E-value 3.2e-21" FT misc_feature 89498..89542 FT /note="PS01211 Uncharacterized protein family UPF0001 FT signature" FT CDS 90054..90686 FT /transl_table=11 FT /gene="ML0920" FT /product="hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein TR:O06229 (EMBL:Z95388) (241 aa); FT Fasta score E(): 0, 83.5% identity in 218 aa overlap. Note FT the Mycobacterium leprae protein is 23 aa shorter." FT /db_xref="GOA:Q9CCE1" FT /db_xref="InterPro:IPR007561" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCE1" FT /protein_id="CAC31301.1" FT /translation="MSTLHKVKAYFGMAPMEDYDDEYYDDRSPTHGYGRSRFEEGYGRY FT EGRDYSDLRGDPTGYLPLGYRGGYGDEHRFRPREFDRPDLSRPRLGSWLRNSTRGALAM FT DPRRMAMLFDEGSPLSKITTLRPKDYSEARTIGERFRDGTPVIIDLVSMDNADAKRLVD FT FAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ" FT CDS 90811..91101 FT /transl_table=11 FT /gene="ML0921" FT /product="possible membrane protein" FT /note="Similar to several proteins of unknown function e.g. FT Mycobacterium tuberculosis TR:O06230 (EMBL:Z95388) (96 aa); FT Fasta score E(): 2.8e-32, 88.5% identity in 96 aa overlap FT and Streptomyces coelicolor TR:Q9S2X3 (EMBL:AL109663) (94 FT aa); Fasta score E(): 2.9e-12, 40.7% identity in 86 aa FT overlap. Contains possible membrane spanning hydrophobic FT domains." FT /db_xref="GOA:Q9CCE0" FT /db_xref="InterPro:IPR003425" FT /db_xref="UniProtKB/TrEMBL:Q9CCE0" FT /protein_id="CAC31302.1" FT /translation="MALFYQILGLALFVFWLLLIARVVVEFIRSFSRDWRPNGVTVVIL FT ETIMSITDPPVKLLRRLIPQLTIGAVRFDLSIMVLLLVAFIGMQLALSAAA" FT CDS 91348..92148 FT /transl_table=11 FT /gene="ag84" FT /gene_synonym="ML0922" FT /product="immunogenic protein, antigen 84" FT /note="Identical to the previously sequenced and FT characterised Mycobacterium leprae antigen 84 SW:AG84_MYCLE FT (P46815) (266 aa); Fasta score E(): 0, 100.0% identity in FT 266 aa overlap. Also highly similar to Mycobacterium FT tuberculosis SW:AG84_MYCTU (P46816) (260 aa); Fasta score FT E(): 0, 83.1% identity in 266 aa overlap. Contains several FT possible coiled-coil regions." FT /db_xref="GOA:P46815" FT /db_xref="InterPro:IPR019933" FT /db_xref="UniProtKB/Swiss-Prot:P46815" FT /protein_id="CAC31303.1" FT /translation="MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVENELTQLIEE FT NSDLRQRIEELDHELAAGGGTGAGPVIAVQPTQALSTFEPELVSAKQAPVAAVAETAEE FT LAMKATRVLSLAQDTADQLTSTAKVESDKMLADARVNADQILGEARLTAEATVAEAQQR FT ADAMLADAQTRSEVQSRQAQEKADALQAEAERKHSEIMGAISQQRTVLEGRLEQLRTFE FT REYRTRLKTYLESQLEELGQRGSAAPVDSNADAGGFDQFNRGNN" FT RBS 92209..92213 FT CDS 92221..92613 FT /transl_table=11 FT /gene="ML0923" FT /product="possible membrane protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein TR:O06231 (EMBL:Z95388) (118 aa); FT Fasta score E(): 1.3e-12, 50.4% identity in 129 aa overlap. FT Contains a possible membrane spanning hydrophobic domain." FT /db_xref="UniProtKB/TrEMBL:Q9CCD9" FT /protein_id="CAC31304.1" FT /translation="MLIIALVLALIGLVVLVFAVATSNLLMAWVCIGASVLGVLLLIVD FT AVREHQCIDAANNEDKEDTDQDDGAVYVDYLDEVPAGTSTEAPDAGSQEGDTNSGELSG FT YWGRLTIDTGEQSAVAADDHDNDRAT" FT CDS complement(92696..93050) FT /pseudo FT /transl_table=11 FT /gene="ML0924" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2143 (Best blastx score 106)" FT repeat_region complement(93035..94016) FT /note="Dispersed repeat, RLEP, copy 12" FT RBS 94364..94369 FT CDS 94376..95812 FT /transl_table=11 FT /gene="glnA" FT /gene_synonym="ML0925" FT /product="glutamine synthase class I (EC 6.3.1.2)." FT /note="Highly similar to many glutamine synthetases (EC FT 6.3.1.2) including examples from: Mycobacterium FT tuberculosis SW:GLN1_MYCTU (Q10377) (478 aa); Fasta score FT E(): 0, 91.8% identity in 478 aa overlap and Salmonella FT typhimurium SW:GLNA_SALTY (P06201) (468 aa); Fasta score FT E(): 0, 51.5% identity in 474 aa overlap. Contains Pfam FT match to entry PF00120 gln-synt, Glutamine synthetase. FT Contains PS00182 Glutamine synthetase class-I adenylation FT site. Contains PS00180 Glutamine synthetase signature 1. FT Contains PS00181 Glutamine synthetase putative ATP-binding FT region signature." FT /note="Similar to ML1631" FT /db_xref="GOA:Q9CCD8" FT /db_xref="HSSP:1LGR" FT /db_xref="InterPro:IPR008147" FT /db_xref="UniProtKB/TrEMBL:Q9CCD8" FT /protein_id="CAC31306.1" FT /translation="MTEKTSDDVLKLAKDENIEFVDVQFCDLPGIMQHFTIPASAFDKS FT VFEDGLAFDGSSIRGFQSIHESDMLLFPDPDTARIDPFRAAKTLNVNFFVHDPFTLEPY FT SRDPRNIARKAENYLISTGIADTVYFGAEAEFYIFDSVSFDSRSNGSFYQVDAISGWWN FT TGAATESDGSPNRGYKVRHKGGYFPVAPNDQYVDLRDKMLTNLTNAGFVLEKGHHEVGT FT GGQGEINYQFNTLLHAADDMQLYKYIVKNTAWQNGKTVTFMPKPLFGDNGSGMHTHQSL FT WKGGTPLMYDEIGYAGLSDTARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPIKL FT VYSQRNRSACVRIPITGKNPKAKRLEFRCPDASGNPYLAFSAMLMAGLDGIKNKIEPQA FT PVDKDLYELPPEEAADIPQAPTQLAAVIDRLEEDHDYLTEGSVFTPDLIETWINFKREN FT EIEPVNIRPHPYEFALYYDV" FT misc_feature 94430..95515 FT /note="Pfam match to entry PF00120 gln-synt, Glutamine FT synthetase, score 700.60, E-value 1.4e-222" FT misc_feature 94532..94588 FT /note="PS00180 Glutamine synthetase signature 1" FT misc_feature 95168..95215 FT /note="PS00181 Glutamine synthetase putative ATP-binding FT region signature" FT misc_feature 95555..95593 FT /note="PS00182 Glutamine synthetase class-I adenylation FT site" FT CDS complement(96064..96432) FT /transl_table=11 FT /gene="ML0926" FT /product="hypothetical protein" FT /note="Weakly similar, in parts, to Mycobacterium FT tuberculosis SW:Y940_MYCTU (P71569) (288 aa); Fasta score FT E(): 0.0071, 30.4% identity in 112 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCD7" FT /protein_id="CAC31307.1" FT /translation="MSPTGHCVWRYSQPHRPIPILYRGFGETALRSVARHNGYLGDRIR FT TDSAIAAADRLQELRIGKGVSLDDFTVLTGLTDAGSITSYWCAEDADITGILTMLRMFY FT VESATTLVNKSKDLTLDS" FT CDS complement(96524..96832) FT /transl_table=11 FT /gene="ML0927" FT /product="hypothetical protein" FT /note="unknown." FT /db_xref="UniProtKB/TrEMBL:Q9CCD6" FT /protein_id="CAC31308.1" FT /translation="MKFGISSAFLNTREIIEIAKAADDLDYDDGIGIPYHVVNLETLNT FT PPRISTPKSPPGSGLSAPVTFPLCAVLIQPPKPLVPGVRASGVRNRSRLIIKRDSPL" FT repeat_region 96810..97734 FT /note="Dispersed repeat, RLEP, copy 13" FT RBS complement(96839..96842) FT CDS 98053..98337 FT /transl_table=11 FT /gene="ML0928" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCD5" FT /protein_id="CAC31309.1" FT /translation="MGSHDLLSRCEGWDNWLRLGERRVMRLLLVLLGATGHDRSSRSHL FT CRLRLWRIDPENNPRLRDPQSLNHHGLRSKVSRPCDEILLLPTILYGIA" FT CDS 98587..99186 FT /pseudo FT /transl_table=11 FT /gene="mgtC" FT /gene_synonym="ML0929" FT /product="probable magnesium transport ATPase protein C FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT mgtC (Best blastx score 171)" FT CDS complement(99217..100061) FT /pseudo FT /transl_table=11 FT /gene="ML0930" FT /product="probable dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1812c (Best blastx score 260)" FT CDS 100314..101169 FT /pseudo FT /transl_table=11 FT /gene="ML0931" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1814 (Best blastx score 379)" FT CDS 101352..101937 FT /pseudo FT /transl_table=11 FT /gene="ML0932" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1815 (Best blastx score 237)" FT CDS 102568..103266 FT /pseudo FT /transl_table=11 FT /gene="ML0933" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1816 (Best blastx score 526)" FT CDS 103994..105279 FT /pseudo FT /transl_table=11 FT /gene="ML0934" FT /product="flavoprotein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1817 (Best blastx score 395)" FT repeat_region complement(106108..106128) FT /note="21 bp sequence found at 3'-ends of copies 2, 3, 4 FT and 6 of LEPREP" FT repeat_region complement(106129..108511) FT /note="Dispersed repeat, LEPREP, copy 3" FT CDS complement(106312..106410) FT /pseudo FT /transl_table=11 FT /gene="ML0935" FT /note="Similar to Agrobacterium tumefaciens transposase FT TR:Q44454 (EMBL:Z18270) (366 aa) fasta scores: E(): 0.0002, FT 51.5% id in 33 aa, and to Pseudomonas putida transposase FT tnpa1 TR:Q9R9U9 (EMBL:AJ245436) (355 aa) fasta scores: E(): FT 0.00088, 48.5% id in 33 aa" FT CDS complement(106679..107822) FT /pseudo FT /transl_table=11 FT /gene="ML0936" FT /product="putative group II intron maturase-related FT protein" FT /note="Similar to many e.g. Cryphonectria parasitica FT (Chesnut blight fungus) putative maturase TR:AAF27656 FT (EMBL:AF218567) (778 aa) fasta scores: E(): 7.8e-11, 29.2% FT id in 216 aa" FT stem_loop complement(107142..107195) FT CDS complement(108027..108166) FT /pseudo FT /transl_table=11 FT /gene="ML0937" FT /note="Similar to Pseudomonas putida transposase tnpa1 FT TR:Q9R9U9 (EMBL:AJ245436) (355 aa) fasta scores: E(): FT 3.4e-05, 47.8% id in 46 aa, and to Agrobacterium FT tumefaciens transposase TR:Q44454 (EMBL:Z18270) (366 aa) FT fasta scores: E(): 0.00026, 41.3% id in 46 aa" FT repeat_region complement(108512..108706) FT /note="195 bp sequence found at 5'-end of copies 1 and 3 of FT LEPREP" FT CDS 109892..110188 FT /transl_table=11 FT /gene="ML0938" FT /product="hypothetical protein" FT /note="unknown." FT /db_xref="UniProtKB/TrEMBL:Q9CCD4" FT /protein_id="CAC31319.1" FT /translation="MEHFLDVSTEPRWTEAQRLVTLAAIDIVKTFFKADRDAAGAKINE FT YLRRIGSEGVIAGYNGLCGMLVKHVAEVTGEDPMAVVYRAEETARNVLPEEEE" FT RBS 110178..110183 FT CDS 110185..110427 FT /transl_table=11 FT /gene="ML0939" FT /product="hypothetical protein" FT /note="unknown." FT /db_xref="UniProtKB/TrEMBL:Q9CCD3" FT /protein_id="CAC31320.1" FT /translation="MIGRVVYCGISIQHHTWGPSKFGQSQSCRRSFGHVSCMLGVLEAR FT YNVLAAFAIYTGMKFVSTFISLHDYYAIFMANSIV" FT CDS 110639..110821 FT /pseudo FT /transl_table=11 FT /gene="ML0940" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1115 (Best blastx score 139)" FT CDS 111222..111510 FT /pseudo FT /transl_table=11 FT /gene="ML0941" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1117 (Best blastx score 151)" FT CDS complement(111588..112380) FT /pseudo FT /transl_table=11 FT /gene="ML0942" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1118c (Best blastx score 257)" FT CDS 112745..114125 FT /pseudo FT /transl_table=11 FT /gene="zwf" FT /gene_synonym="ML0943" FT /product="glucose-6-phosphate 1-dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT zwf (Best blastx score 420)" FT CDS 114160..115169 FT /pseudo FT /transl_table=11 FT /gene="gnd2" FT /gene_synonym="ML0944" FT /product="6-phosphogluconate dehydrogenase (Gram +) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT gnd2 (Best blastx score 395)" FT CDS complement(115197..116007) FT /pseudo FT /transl_table=11 FT /gene="ML0945" FT /product="possible non-heme bromoperoxidase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT bpoB (Best blastx score 308)" FT RBS 116225..116229 FT CDS 116230..116553 FT /transl_table=11 FT /gene="ML0946" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O05568 (EMBL:Z94723) (107 FT aa); Fasta score E(): 0, 100.0% identity in 107 aa overlap. FT Also similar to Mycobacterium tuberculosis TR:O06818 FT (EMBL:Z95844) (491 aa); Fasta score E(): 0.00066, 38.7% FT identity in 106 aa overlap, a proposed member of the FT PGRS-family. Contains Pfam match to entry PF00934 PE, PE FT family." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:O05568" FT /protein_id="CAC31327.1" FT /translation="MPVSFVSVVLEFVSAMASDSANVGLTIAEATTIAAGSNDQRCSHP FT GADQCRWPSWCCSVYMPGFPGARHASGGGGRSTRQFVQALTGAASAYASAEVANASPLQ FT ILE" FT misc_feature 116236..116526 FT /note="Pfam match to entry PF00934 PE, PE family, score FT 0.70, E-value 6.2e-05" FT CDS complement(117520..117777) FT /transl_table=11 FT /gene="ML0947" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCD2" FT /protein_id="CAC31328.1" FT /translation="MAAQEQFLPATTAAPDVRDLEKRIADLDSEGIWSESVFPSLGTWS FT GSFLDSGAVALSDAGIQRLVQKNNYQLIIAANSHNTSVKY" FT CDS 118089..118537 FT /pseudo FT /transl_table=11 FT /gene="ML0948" FT /product="hypothetical protein (pseudogene)." FT /note="Possible pseudogene of a protein of unknown function FT from Streptomyces coelicolor TR:Q9X7R8(EMBL:AL049863)." FT CDS complement(118730..119143) FT /transl_table=11 FT /gene="ML0949" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="GOA:Q9CCD1" FT /db_xref="InterPro:IPR001647" FT /db_xref="UniProtKB/TrEMBL:Q9CCD1" FT /protein_id="CAC31330.1" FT /translation="MTTSARTHRWAKTGAIQRRILDAAIEVFATRSFTTATMTDAMTGS FT GAIIGSIYHHFGGKRKLFLAIFEQMGRQRRPPHRRGDATSGPIRPSGDRSAAGIRSPRT FT GPTSRRCGKTGTRPGCCRPETHLQASRSPVATA" FT CDS complement(119155..119355) FT /transl_table=11 FT /gene="ML0950" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCD0" FT /protein_id="CAC31331.1" FT /translation="MSVTRRRAAVLARMSSIAAMFTPVQHVRLAYPIGHAPEQRNASPS FT TPTGVISARQCKVRLAARHTR" FT CDS 119349..120281 FT /pseudo FT /transl_table=11 FT /gene="ML0951" FT /product="possible epoxide hydrolase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT ephC (Best blastx score 389)" FT CDS 120289..121493 FT /pseudo FT /transl_table=11 FT /gene="ML0952" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1125 (Best blastx score 383)" FT CDS 121893..122132 FT /transl_table=11 FT /gene="ML0953" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCC9" FT /protein_id="CAC31334.1" FT /translation="MAISAVMAAELAAGPLLAMTPMEAAKRQVRLQEFESTLEPILFDG FT YAVRSYGLIVAAVVREGKAAKQVRRSFDHCDDAR" FT CDS complement(122419..123020) FT /pseudo FT /transl_table=11 FT /gene="ML0954" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1126c (Best blastx score 364). Note the N-terminal region FT of this putative pseudogene was previously published FT TR:O05567." FT CDS complement(123017..124822) FT /transl_table=11 FT /gene="ppdK" FT /gene_synonym="ML0955" FT /product="pyruvate, phosphate dikinase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae pyruvate, phosphate dikinase TR:O05566 (EMBL:Z94723) FT (601 aa); Fasta score E(): 0, 99.8% identity in 601 aa FT overlap. Also highly similar to pyruvate, phosphate FT dikinases from Mycobacterium tuberculosis TR:O06579 FT (EMBL:Z95585) (490 aa); Fasta score E(): 0, 71.8% identity FT in 478 aa overlap and Clostridium symbiosumSW:PODK_CLOSY FT (P22983) (873 aa); Fasta score E(): 0, 35.2% identity in FT 537 aa overlap. Contains Pfam match to entry PF00391 FT PEP-utilizers, PEP-utilizing enzymes. Contains Pfam match FT to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, FT PEP/pyruvate binding domain." FT /db_xref="GOA:O05566" FT /db_xref="HSSP:1DIK" FT /db_xref="InterPro:IPR013816" FT /db_xref="UniProtKB/TrEMBL:O05566" FT /protein_id="CAC31336.1" FT /translation="MPGQSHKEPHRRATSTPRSLKQATSELRWALSLAAPESPAFMRHL FT LGNAHDKVDITTSSEHVAAFTEHAIVLLNGNAHQTRELLGGKGYNINAMRRHQLAVPPA FT FCITTEVGVRYLAAPTPTMEAIWNDVLDQMRWLEAETSRTFGWGPRPLLVSIRSGAVQS FT MPGMMDTILNLGINDPVEQALAAASPSPIPQTFARDTRLRFIRTYRRIVDPLNPPPANT FT YDQLRAAIESIFSSWNSPRAVAYRTHYGLDDQSGTAVIVQAMVFGNQGAYSGAGTLFSR FT NPITRESKLFGEWLPGGQGDDVVSGLVEVQPITSLRDEQPTVYDELVDTAGRLERLGSD FT VQEIEFTTEDSKLWLLQTRVAERSAQVAVRLALQLWQEGLIDDAEALRRVTPVHVETVL FT LPVLQPENHLSATLLAKGTPTCPGVISGKAYTEVDEALDAAESAEQVILVRDHTRPDDV FT LGMLASQGVVTEVGGAASHAAVVSRELSRVAVVGCGQGTAVSLAGKQITVDGDKGEVRQ FT GNLTLSAWSENETPELRELADIARRISPLRVHMTEDHTRLDDSSDTAVRLAINTGHADV FT VSATPLIVMMTTLRLQDSKDSSAKS" FT misc_feature complement(123278..123484) FT /note="Pfam match to entry PF00391 PEP-utilizers, FT PEP-utilizing enzymes, score 57.50, E-value 5.9e-16" FT misc_feature complement(123659..124621) FT /note="Pfam match to entry PF01326 PPDK_N_term, Pyruvate FT phosphate dikinase, PEP/pyruvate binding domain, score FT 484.20, E-value 1.1e-141" FT CDS 124867..125376 FT /transl_table=11 FT /gene="ML0956" FT /product="putative integral membrane protein." FT /note="Almost identical to the previously sequenced FT Mycobacterium leprae hypothetical protein TR:O05565 FT (EMBL:Z94723) (214 aa); Fasta score E(): 0, 100.0% identity FT in 169 aa overlap. Also highly similar to Streptomyces FT coelicolor putative membrane protein TR:Q9RKN9 FT (EMBL:AL133220) (180 aa); Fasta score E(): 2.8e-13, 43.8% FT identity in 137 aa overlap. Contains multiple possible FT membrane spanning hydrophobic domains and a possible FT N-terminal signal sequence." FT /db_xref="InterPro:IPR011637" FT /db_xref="UniProtKB/TrEMBL:Q9CCC8" FT /protein_id="CAC31337.1" FT /translation="MTSYDIGLLILRLVLGLTLAAHGYNKFFCGGRIPGTARWFESIGM FT KPGTFHATVAATTEISAGLGLAAGLLTPIPAAGFVSLMMVAAWMVHRPNGFFIVKEGWE FT YNLVLATGAVVVATLGAGRFSLDWLIFGKNWFDSCDGLLISVLLGFAGALGQLLIFYRP FT PVKKTS" FT CDS complement(125854..126228) FT /transl_table=11 FT /gene="ML0957" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCC7" FT /protein_id="CAC31338.1" FT /translation="MLRMEVVRRFQTLSFSMRRRSGYPTRWGGVGSIYQCIATELGAAL FT HVSQAVRHIEQDRNDVHGTHQCVDSADTPNHRGNSAGNRHPDRLRADAAGSSFLHQYAV FT FKISVCYDELIKRTDVLCGQ" FT RBS complement(126231..126237) FT CDS 126239..126670 FT /transl_table=11 FT /gene="ML0958" FT /product="putative membrane protein" FT /note="possible membrane protein which contains a potential FT membrane spanning hydrophobic domain." FT /db_xref="UniProtKB/TrEMBL:Q9CCC6" FT /protein_id="CAC31339.1" FT /translation="MCTGRPTLSPVSCRAGLDNMFLSSYSSRLMRYHLAVSLAPPGLHR FT FSTAARLVTAHLLIVHGIVQPYWCFLPSMIITASLLLYRLYSRHDERLHQRVNTILARP FT DPCAVTVNSDLVVTGFGEKCSHLPCNVPPKGHRAAHFLK" FT CDS 126912..127265 FT /transl_table=11 FT /gene="ML0959" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCC5" FT /protein_id="CAC31340.1" FT /translation="MARTLRCCAPHNIAPSNRRPAGRCHSLISLLHREIYQVQQEKNRP FT DRVDQHGNSRVLTMKWSLIRVAAVWRRPALAVPLPQRGESRRDPAMTMDETVASGHQTF FT WQRMRRSQPECVF" FT CDS 127277..127736 FT /pseudo FT /transl_table=11 FT /gene="ML0960" FT /product="possible membrane transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1132 (Best blastx score 183)" FT CDS complement(127777..130059) FT /transl_table=11 FT /gene="metE" FT /gene_synonym="ML0961" FT /product="5-methyltetrahydropteroyltriglutamate-homocystein FT methyltransferase." FT /note="Identical to the previously sequenced Mycobacterium FT leprae 5-methyltetrahydropteroyltriglutamate--homocysteine FT methyltransferase (EC 2.1.1.14) SW:METE_MYCLE (O05564) (760 FT aa); Fasta score E(): 0, 100.0% identity in 760 aa overlap. FT Also highly similar to MetE orthologues from Mycobacterium FT tuberculosis SW:METE_MYCTU (O06584) (759 aa); Fasta score FT E(): 0, 85.0% identity in 759 aa overlap and Escherichia FT coli SW:METE_ECOLI (P25665) (752 aa); Fasta score E(): 0, FT 47.5% identity in 754 aa overlap. Contains Pfam match to FT entry PF01717 Methionine_synt, Methionine synthase, FT vitamin-B12 independent." FT /db_xref="GOA:O05564" FT /db_xref="InterPro:IPR006276" FT /db_xref="UniProtKB/Swiss-Prot:O05564" FT /protein_id="CAC31342.1" FT /translation="MDELVTTQSFTATVTGSPRIGPRRELKRATEGYWAKRTSRSELES FT VASTLRRDMWSDLAAAGLDSVPVNTFSYYDQMLDTAFMLGALPARVAQVSDDLDQYFAL FT ARGNNDIKPLEMTKWFDTNYHYLVPEIEPATTFSLNPGKILGELKEALEQRIPSRPVII FT GPVTFLLLSKGINGGGAPIQRLEELVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDA FT PALAEAVYTALGSVSKRPAIYVATYFGNPGASLAGLARTPIEAIGVDFVCGADTSVAAV FT PELAGKTLVAGIVDGRNIWRTDLESALSKLATLLGSAATVAVSTSCSTLHVPYSLEPET FT DLDDNLRSWLAFGAEKVAEVVVLARALRDGRDAVADEIAASNAAVASRRSDPRLHNGQV FT RARIDSIVASGTHRGDAAQRRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEI FT DEAEYISRMKKEVADAIKLQEQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQS FT YGSRCVRPPILYGDVSRPHPMTIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPL FT ADTANQVALAIRDETVDLQSAGIAIIQVDEPALRELLPLRRADQDEYLCWAVKAFRLAT FT SGVADSTQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGP FT GVYDIHSPRVPSTDEIAKSLRAALKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAA FT RQVRAGA" FT misc_feature complement(127795..128766) FT /note="Pfam match to entry PF01717 Methionine_synt, FT Methionine synthase, vitamin-B12 independent, score 798.90, FT E-value 1.9e-236" FT CDS complement(130782..131101) FT /pseudo FT /transl_table=11 FT /gene="ML0962" FT /product="possible transposase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT putative transposase Rv1313c (Best blastx score 152)" FT CDS 131298..131762 FT /transl_table=11 FT /gene="ML0963" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCC4" FT /protein_id="CAC31344.1" FT /translation="MPRTGDVYGDVRRDQPCLLLLRHRLCPYQVRQDCRFDGLSTTDLE FT SKVYYPQGCPISMAKSVLGGNLVNFDGCLTERVLDGATTSRSWCRRALWGSVVSGAMRH FT RHHRHCMGLALFQEPIMYKQGSRVVVVIPSPIQIWQRFNLRLLLQLIVHC" FT CDS 131800..132057 FT /transl_table=11 FT /gene="ML0964" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCC3" FT /protein_id="CAC31345.1" FT /translation="MVMSMGRAIEVVVEPPMCLCTKQGCPLPACWKRNPMDLCESMFVT FT VRTRVAYLSPAVVDADRMSAAIGNAGHLIGTLLADLGYKW" FT CDS complement(133793..134785) FT /pseudo FT /transl_table=11 FT /gene="ML0965" FT /product="possible conserved hypothetical protein FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1138c (Best blastx score 217)" FT CDS complement(134796..135289) FT /pseudo FT /transl_table=11 FT /gene="ML0966" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1139c (Best blastx score 225)" FT CDS complement(135310..136331) FT /pseudo FT /transl_table=11 FT /gene="ML0967" FT /product="polyketide synthase (chalcone synthase-like) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pks10 and pks11 (Best blastx score 288)" FT CDS 136837..137335 FT /pseudo FT /transl_table=11 FT /gene="ML0968" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1140 (Best blastx score 297)" FT CDS 137505..138598 FT /pseudo FT /transl_table=11 FT /gene="ML0969" FT /product="[alpha]-methyl acyl-CoA racemase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT mcr (Best blastx score 1092)" FT CDS 138624..139418 FT /pseudo FT /transl_table=11 FT /gene="ML0970" FT /product="short-chain alcohol dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1144 (Best blastx score 282)" FT repeat_region 139035..139074 FT /note="4 tandem copies of 10 bp direct repeat, Consensus, FT TTATTAATAA" FT CDS 140053..140906 FT /pseudo FT /transl_table=11 FT /gene="ML0971" FT /product="probable drug transport protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1145 (Best blastx score 305)" FT CDS 140947..141214 FT /pseudo FT /transl_table=11 FT /gene="ML0972" FT /product="probable drug transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1146 (Best blastx score 131)" FT CDS 141223..141417 FT /pseudo FT /transl_table=11 FT /gene="ML0973" FT /product="hypothetical protein (pseudogene)." FT /note="Similar to Mycobacterium tuberculosis hypothetical FT protein Rv1147 TR:O06547." FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1147." FT repeat_region 141414..142430 FT /note="REPLEP region 5, 5'-end most similar to REPLEP 6; FT 3'-end most similar to REPLEP 1, 4 and 6" FT repeat_region 141484..141504 FT /note="21 bp repeat found at 5'-end of REPLEP copies 1, 2, FT 5, 6 and 11" FT repeat_region 141505..142385 FT /note="Dispersed repeat, REPLEP, copy 5. Ends of element FT show similarity, bases 1-95 with 783-880 and vice-versa, FT 68% identity" FT repeat_region 142386..142430 FT /note="45 bp REPLEP-associated sequence" FT CDS complement(142459..143286) FT /pseudo FT /transl_table=11 FT /gene="ML0974" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2751 (Best blastx score 348)" FT CDS complement(143307..144159) FT /pseudo FT /transl_table=11 FT /gene="ML0975" FT /product="putative dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2750 (Best blastx score 216)" FT CDS complement(144200..144442) FT /pseudo FT /transl_table=11 FT /gene="ML0976" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2749 (Best blastx score 131)" FT CDS 144496..147156 FT /transl_table=11 FT /gene="ftsK" FT /gene_synonym="ML0977" FT /product="Cell division protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O05560 (EMBL:Z94723) (886 FT aa); Fasta score E(): 0, 100.0% identity in 886 aa overlap. FT Also highly similar to many proteins involved in cell FT division e.g. Escherichia coli SW:FTSK_ECOLI (P46889) (1329 FT aa); Fasta score E(): 0, 43.9% identity in 531 aa overlap FT and Mycobacterium tuberculosis TR:O33290 (EMBL:AL008967) FT (883 aa); Fasta score E(): 0, 78.1% identity in 885 aa FT overlap. Contains multiple possible membrane spanning FT hydrophobic domains. Contains Pfam match to entry PF01580 FT FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:O05560" FT /db_xref="InterPro:IPR002543" FT /db_xref="UniProtKB/Swiss-Prot:O05560" FT /protein_id="CAC31358.1" FT /translation="MIRVIRSSFYPRMLTIDLDAWEETKKQSIASVACSADDIIAIRLV FT AMASKTVARSGNRTSSLKATSRGVSQSRRPVPPRPRRNRPAERRNQSLLLAAGLTCGQA FT IRATWLVAAKGAGGAARSIGRARDIEPGHRRDGIALALLGLAVVVAASSWFDAARPIGA FT WVDAVLRTFIGSAVVVLPLVIAAVAVVLMRTQPNLDTRPRLILGATLIALSFLGLRHLW FT SGSPETPEVRRGAAGFLGFAIGGPLSDGLTAWIAAPLLFIGALFGLLLLTGTTVREVPE FT VLRGMFDTGLFQRDYDDQYDAEYRYDDIPGAPPEDFSGCYDGSLVGGGDAEQKVRGWPV FT TDLAEVSLQDDVPTTPEPAVQAGTAEVHRLTPRSAEEHRTQALDRAIEGSYTLPSMSLL FT LTGDPPKKCSAANNHMASAIGGVLTQFKVDAAVTGCTRGPTVTRYEVELGPGVKVEKIT FT ALQKNIAYAVATESVRMLAPIPGKSAVGIEVPNTDREAVRLADVLTAPSTRRDHHSLVI FT GLGKDIEGNFISANLAKMPHLLVAGSTGSGKSSFVNSMLVSLLTRSTPEEVRMILIDPK FT MVELTPYEGIPHLITPIITQPKKAAAALVWLVEEMEQRYQDMQASRVRHIDVFNEKVRS FT GEITAPLGSQRVYRPYPYILAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLAT FT QRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQAGAEKLIGMGDGLFLPMGASKPV FT RLQGAFITDEEIHAVVTACKDQAEPEYTEGVTTAKTTGERTDVDPDIGDDMDVFLQAVE FT LVVSSQFGSTSMLQRKLRVGFAKAGRLMDLMETRSIVGPSEGSKAREVLVKADELAATL FT ALIRGGASADGSNED" FT misc_feature 145987..146592 FT /note="Pfam match to entry PF01580 FtsK_SpoIIIE, FT FtsK/SpoIIIE family, score 317.70, E-value 1.4e-91" FT misc_feature 146119..146142 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(147166..147708) FT /transl_table=11 FT /gene="ML0978" FT /product="putative acetyltransferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 FT aa); Fasta score E(): 0, 100.0% identity in 180 aa overlap. FT Also similar to several acetyltransferases including: FT Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) FT SW:ARGA_ECOLI (P08205) (443 aa); Fasta score E(): 0.0013, FT 26.8% identity in 123 aa overlap and Streptomyces FT coelicolor putative acetyltransferase TR:Q9X8N2 FT (EMBL:AL049628) (169 aa); Fasta score E(): 0, 59.8% FT identity in 164 aa overlap. Highly similar to Mycobacterium FT tuberculosis hypothetical protein Rv2747 TR:O33289 FT (EMBL:AL008967) (174 aa); Fasta score E(): 0, 86.2% FT identity in 174 aa overlap . Contains Pfam match to entry FT PF00583 Acetyltransf, Acetyltransferase (GNAT) family." FT /db_xref="GOA:O05559" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:O05559" FT /protein_id="CAC31359.1" FT /translation="MSILLAVTKNSQNYLPVVRRARTSDIPAIKQLVDTYAGKILLEKN FT LVTLYEAVQEFWVAEHPDIPGKVVGCGALHVLWSDLGEIRTVAVDPAMTGHGVGGTIVN FT RLLEVARKLELERLFVLTFETEFFSQHGFTEIEGTPVTAEVFEEMCRSYDIGVAEFLDL FT SYVKPNTLGNSRMLLVL" FT misc_feature complement(147307..147657) FT /note="Pfam match to entry PF00583 Acetyltransf, FT Acetyltransferase (GNAT) family, score 36.30, E-value FT 6.8e-07" FT CDS 147775..148356 FT /transl_table=11 FT /gene="ML0979" FT /product="CDP-diacylglycerol--glycerol-3-phosphate FT 3-phosphatidyltransferase (EC FT 2.7.8.5)(phosphatidylglycerophosphate synthase)" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49839 (EMBL:U00019) (193 aa); Fasta score E(): FT 0, 100.0% identity in 193 aa overlap. Also highly similar FT to many phosphatidylglycerophosphate synthases including: FT Mycobacterium tuberculosis Rv2746c TR:O33288 FT (EMBL:AL008967) (209 aa); Fasta score E(): 0, 77.1% FT identity in 188 aa overlap and Bacillus subtilis FT SW:PGSA_BACSU (P46322) (193 aa); Fasta score E(): 5.6e-17, FT 35.8% identity in 193 aa overlap. Contains multiple FT possible membrane spanning hydrophobic domains. Contains FT Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol FT phosphatidyltransferase. Contains PS00379 CDP-alcohol FT phosphatidyltransferases signature." FT /db_xref="GOA:Q49839" FT /db_xref="InterPro:IPR004570" FT /db_xref="UniProtKB/TrEMBL:Q49839" FT /protein_id="CAC31360.1" FT /translation="MVDCVRIANLANILTGLRLMLVPVFLVALFAGNGHEIVGRIAAFV FT IFTVACITDRLDGLLARRYGMATEFGAFVDPIADKTLIGAALIGLSMLGDLPWWVTVLI FT MTRELGVTLLRLAVIHRGVIPASWGGKLKTVVQAVAIGLFLLPLTQLSVPFHVGAAVVM FT AVAVVLTVVTGVDYVAGTIRAVRGVHQTAS" FT misc_feature 147904..148326 FT /note="Pfam match to entry PF01066 CDP-OH_P_transf, FT CDP-alcohol phosphatidyltransferase, score 159.90, E-value FT 4.3e-44" FT misc_feature 147943..148011 FT /note="PS00379 CDP-alcohol phosphatidyltransferases FT signature" FT CDS 148468..148751 FT /pseudo FT /transl_table=11 FT /gene="ML0980" FT /product="hypothetical protein (pseudogene)." FT CDS 148891..149719 FT /pseudo FT /transl_table=11 FT /gene="ML0981" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT 35kd immunogenic protein 35kd_ag (Best blastx score 624)" FT CDS 149754..150602 FT /pseudo FT /transl_table=11 FT /gene="ML0982" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2743c (Best blastx score 792)" FT CDS 150700..150910 FT /pseudo FT /transl_table=11 FT /gene="ML0983" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2742c (Best blastx score 144)" FT CDS complement(151024..151518) FT /transl_table=11 FT /gene="ML0984" FT /product="conserved hypothetical protein." FT /note="Almost identical to the previously sequenced FT Mycobacterium leprae hypothetical protein TR:Q49850 FT (EMBL:U00019) (178 aa); Fasta score E(): 0, 100.0% identity FT in 149 aa overlap. Also highly similar to Mycobacterium FT tuberculosis hypothetical protein TR:O33283 (EMBL:AL008967) FT (149 aa); Fasta score E(): 3e-28, 52.0% identity in 150 aa FT overlap." FT /db_xref="InterPro:IPR013100" FT /db_xref="UniProtKB/TrEMBL:Q9CCC2" FT /protein_id="CAC31365.1" FT /translation="MYHAIAPLCHVSPKLVAIAELTEASVQGVENIRTVEVFLAALQDA FT GLRNRIRDVGRQPRVYQNVGLPTIHGRSKTITLWRKMADCIGFEIKIHRIAAVAIAVLC FT ERADAVIVGPLWMQFWVCGTFEVQNKRIMLWRNYFDLFDLFKATMRSLVALRIPSLNAA FT F" FT CDS 151510..152688 FT /transl_table=11 FT /gene="ML0985" FT /product="possible glycosyltransferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae possible glycosyl transferase TR:Q49841 FT (EMBL:Z94723) (392 aa); Fasta score E(): 0, 100.0% identity FT in 392 aa overlap. Also highly similar to Mycobacterium FT tuberculosis probable transferase Rv2739c TR:O33282 FT (EMBL:AL008967) (388 aa); Fasta score E(): 0, 80.9% FT identity in 388 aa overlap and Erwinia herbicola FT SW:CRTX_ERWHE (Q01330) (413 aa); Fasta score E(): 7.5e-07, FT 26.1% identity in 410 aa overlap." FT /db_xref="GOA:Q49841" FT /db_xref="InterPro:IPR002213" FT /db_xref="UniProtKB/TrEMBL:Q49841" FT /protein_id="CAC31366.1" FT /translation="MVHYMRVAVVAGPDPGHSFPAIALCQRFAEAGDTPTLFTGVECVD FT IARAAGVETALLDGLVAVDDDVDAGARIHRRAAQMAVLNVPVLRDLAPDLIVSDVITAA FT GGMAAELLGIPWIELNPHPLYLPSKGLPPIGSGLASGVGIHGRMRDATMRALTARSWRA FT GLRERAAVRVQIGLPACDSGPLRRLIATLPALEVSRPDWPAEAVVVGPLHFEPTDRVLQ FT IPSGSGPVIVVAPSTALTGISGMAQTALDALVPGDTLPSGSRVVVSRLNGPDLTVPSWA FT VAGLVHQTKLLAHADVVICGGGHGMVAKTLLAGVPLVVVPGGGDQWEMANRVVRQGSAQ FT LIRPLTAAALLAAVNKVLSSPDYREAAQRAAISIAGVADPVQVCHEALGLAG" FT CDS 152702..152905 FT /transl_table=11 FT /gene="ML0986" FT /product="conserved hypothetical protein" FT /note="Highly similar to proteins of undefined function FT from Mycobacterium tuberculosis Rv2738c TR:O33281 FT (EMBL:AL008967) (68 aa); Fasta score E(): 7.9e-24, 85.1% FT identity in 67 aa overlap and Streptomyces coelicolor FT TR:O50484 (EMBL:AL020958) (64 aa); Fasta score E(): FT 2.5e-08, 44.4% identity in 63 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCC1" FT /protein_id="CAC31367.1" FT /translation="MAGVRLTEFHERVVLRFGAAYGASVLVDHVLTGFDGRTVAQAIED FT GVELRDVWRALCVDFDVPRDQW" FT CDS 153056..155191 FT /transl_table=11 FT /gene="recA" FT /gene_synonym="ML0987" FT /product="RecA protein" FT /note="Identical to the previously sequenced and FT characterised Mycobacterium leprae RecA protein involved in FT DNA recombination and the SOS response SW:RECA_MYCLE FT (P35901) (711 aa); Fasta score E(): 0, 100.0% identity in FT 711 aa overlap. Also highly similar to many others e.g. FT Mycobacterium tuberculosis SW:RECA_MYCTU (P26345) (790 aa); FT Fasta score E(): 0, 46.7% identity in 814 aa overlap. Note FT the Mycobacterium leprae RecA protein is known to possess FT an intron which is self-spliced at the post-translational FT level. Contains 2 Pfam matches to entry PF00154 recA, recA FT bacterial DNA recombination proteins. Contains PS00321 recA FT signature. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00881 Protein splicing signature." FT /db_xref="GOA:P35901" FT /db_xref="HSSP:1MO6" FT /db_xref="InterPro:IPR001553" FT /db_xref="UniProtKB/Swiss-Prot:P35901" FT /protein_id="CAC31368.1" FT /translation="MAQVPDREKALELAMAQIEKNYGKGSVMRLGDEMCQPISVIPTGS FT IALDVALGIGGLPRGRIVEIYGPESSGKTTVALHAVANAQAVGGVAAFIDAEHALEPEY FT AKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAALVPRAELEGEMGDS FT YVGLQARLMSQALRKMTGALSNSGTTAIFINQLREKIGVMFGCMNYSTRVTLADGSTEK FT IGKIVNNKMDVRVLSYDPVTDRIVPRKVVNWFNNGPAEQFLQFTVEKSGSNGKSQFAAT FT PNHLIRTPGGWTEAGNLIAGDRVLAVEPHMLSDQQFQVVLGSLMGDGNLSPNLCDRNGV FT RFRLLGYGCKQVEYLQWKKALMGNIRHTVRENSMGASFIDFTPLPELVELQRAVYLGDG FT KKFLSEEYLKALTPLVLAIWYMDDGSFTVGSKRVQERTAGGSGRIEICVDAMTEGTRVR FT LRDYLCDTHGLDVRLREVGSAGKAVLVFSTAATAKFQSLIAPYVAPSMEYKLLPQFRGR FT GSVTPQFVEPTQQLVPARVLDVHVKLSTRSMNRFDIEVEGNHNYFVDGVMVHNSPETTT FT GGKALKFYASVRMDVRRIETLKDGVDAVGNRTRVKIVKNKVSPPFKQAEFDILYGKGIS FT REGSLIDMGVEQGFVRKSGSWFTYEGEQLGQGKENARNFLLENADVANEIEKKIKEKLG FT IGAVVTDDDILPTPVDF" FT misc_feature 153080..153670 FT /note="Pfam match to entry PF00154 recA, recA bacterial DNA FT recombination proteins, score 495.50, E-value 5e-146" FT misc_feature 153254..153277 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 154745..154768 FT /note="PS00881 Protein splicing signature" FT misc_feature 154748..155140 FT /note="Pfam match to entry PF00154 recA, recA bacterial DNA FT recombination proteins, score 263.10, E-value 3.6e-77" FT misc_feature 154793..154819 FT /note="PS00321 recA signature" FT CDS 155157..155672 FT /transl_table=11 FT /gene="recX" FT /gene_synonym="ML0988" FT /product="putative regulatory protein RecX" FT /note="Identical to the previously sequenced Mycobacterium FT leprae putative regulatory protein RecX, though to interact FT with RecA SW:RECX_MYCLE (P37859) (171 aa); Fasta score E(): FT 0, 100.0% identity in 171 aa overlap. Also highly similar FT to RecX from Mycobacterium tuberculosis Rv2736c FT SW:RECX_MYCTU (O33280) (174 aa); Fasta score E(): 0, 77.0% FT identity in 174 aa overlap and several others. Note the FT overlap with upstream recA." FT /db_xref="GOA:P37859" FT /db_xref="InterPro:IPR003783" FT /db_xref="UniProtKB/Swiss-Prot:P37859" FT /protein_id="CAC31369.1" FT /translation="MTTSCPPPSISDREEQARILCLRLLTARSRTRAQLFGQLAKRGYA FT DHVSERVLDRLAAVGLLDDNDFAEQWVRSRRANVGKSKRALAADLRAKGIDSEVITTVL FT AGIDPAVERERAEQLVRTRLRREVLSEDDARVSRRLMAMLARRGYSQTTICEVVVAELA FT AERERRRV" FT CDS 155731..157284 FT /transl_table=11 FT /gene="ML0989" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein SW:YR33_MYCLE (Q49842) (516 FT aa); Fasta score E(): 0, 99.8% identity in 516 aa overlap. FT Also highly similar to many other proteins of undefined FT function belonging to the the Pfam UPF0004 family, FT including: Mycobacterium tuberculosis Rv2733c SW:YR33_MYCTU FT (O33238) (512 aa); Fasta score E(): 0, 80.4% identity in FT 509 aa overlap and Bacillus subtilis YMCB_BACSU. Contains FT Pfam match to entry PF00919 UPF0004, Uncharacterized FT protein family UPF0004. Contains PS01278 Uncharacterized FT protein family UPF0004 signature." FT /db_xref="GOA:Q49842" FT /db_xref="InterPro:IPR013848" FT /db_xref="UniProtKB/Swiss-Prot:Q49842" FT /protein_id="CAC31370.1" FT /translation="MVTRDAGMADDAATGSTRTYQVRTYGCQMNVHDSERLAGLLEAAG FT YQRAADEADVGDADVVVFNTCAVRENADNRLYGNLSHLAPRKRNNPDMQIAVGGCLAQK FT DKHTVLSKAPWVDIVFGTHNLGSLPTLLDRARHNKVAQVEIVEALQHFPSSLPSARESD FT YAAWVSISVGCNNSCTFCIVPSLRGKEVDRSPADILAEVEALVADGVLEVTLLGQNVNA FT YGVSFADPALARNRGSFAELLRSCGSIDGLERVRFTSPHPAEFTYDVIEAMAQTPNVCP FT SLHMPLQSGSDRVLRAMRRSYRVERYLGIIGQVRAAMPHAAITTDLIVGFPGETEEDFA FT ATLDVVRQVRFTAAFTFQYSKRPGTPAAELGGQLPKAVVQERYERLVELQEQICMEENR FT VLIGRIVELLVTTGEGRKDARTARRTGRARDGRLVHFALDTPWEAQVRPGDIITVMVTE FT AAPHHLIADAGILTHRRTRAGDAHAARQCPRSIGLGQIPLGMPSVGQHSASIGSAGCAR FT " FT misc_feature 155785..157137 FT /note="Pfam match to entry PF00919 UPF0004, Uncharacterized FT protein family UPF0004, score 795.30, E-value 5e-250" FT misc_feature 156232..156294 FT /note="PS01278 Uncharacterized protein family UPF0004 FT signature" FT CDS 157281..157910 FT /transl_table=11 FT /gene="ML0990" FT /product="possible conserved membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49834 (EMBL:U00019) (209 FT aa); Fasta score E(): 0, 100.0% identity in 209 aa overlap. FT Also highly similar to Mycobacterium tuberculosis Rv2732c FT TR:O33237 (EMBL:Z98209) (204 aa); Fasta score E(): 0, 70.6% FT identity in 201 aa overlap. Contains possible membrane FT spanning hydrophobic domains." FT /db_xref="UniProtKB/TrEMBL:Q49834" FT /protein_id="CAC31371.1" FT /translation="MNEEPNIVDFPDSNPLQAALEAEELRVVREIDSGAKIFVLIAVLV FT FMLLGSFILPHTGQVRGWDVLFDSHGAGAAAVALPLRIFAWLSLVFGVGFSMLALMTRR FT WVLAWIALAGAAMASIVGLLAVWSRQTVAVGQPGPGVGLIVAWITLILLTFHWARVVWS FT STIVQLATEEQRRRVVAQQQSKTLLDGLYSAGNRDTRTRSDPQVGS" FT CDS complement(157913..159287) FT /pseudo FT /transl_table=11 FT /gene="ML0991" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2731 (Best blastx score 491)" FT CDS complement(159846..160079) FT /pseudo FT /transl_table=11 FT /gene="ML0992" FT /product="serine-threonine protein kinase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pknE (Best blastx score 104)" FT CDS 160766..162375 FT /pseudo FT /transl_table=11 FT /gene="ML0993" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2729c (Best blastx score 226)" FT RBS 162614..162619 FT CDS 162620..163318 FT /transl_table=11 FT /gene="ML0994" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49835 (EMBL:U00019) (232 FT aa); Fasta score E(): 0, 99.6% identity in 232 aa overlap. FT Also highly similar to proteins of undefined function from FT Mycobacterium tuberculosis Rv2728c TR:O33233 (EMBL:Z98209) FT (231 aa); Fasta score E(): 0, 68.5% identity in 232 aa FT overlap and Streptomyces coelicolor TR:O69964 FT (EMBL:AL022268) (237 aa); Fasta score E(): 1.3e-13, 32.9% FT identity in 243 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49835" FT /protein_id="CAC31375.1" FT /translation="MLSAIAIVPSAPVLVPELTGAAAAEVADLRSAVLAVAACLPPCWI FT VVGTGRADDVVGPGGCLGTFAGFGADVRVRLSPQVGGEAELLVDFPVCALIAAWVRGQS FT QLDASAQVRVYCGDHDPDMALACGRQLRVEIEQAPDPIGVLVVADGATTLTSSSPGGYD FT PSAADAELVLDDALASGDVAALTRLSCQISGRVAFQVLAGLVEPGPRLAKELYRGAPYG FT VGYFVGVWQP" FT CDS 163315..164250 FT /transl_table=11 FT /gene="miaA" FT /gene_synonym="ML0995" FT /product="tRNA [delta](2)-isopentenylpyrophosphate FT transferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae tRNA delta(2)-isopentenylpyrophosphate transferase FT (EC 2.5.1.8) SW:MIAA_MYCLE (P46811) (311 aa); Fasta score FT E(): 0, 100.0% identity in 311 aa overlap, as well as FT several other IPP transferases e.g. from Mycobacterium FT tuberculosis SW:MIAA_MYCTU (O33232) (314 aa); Fasta score FT E(): 0, 82.2% identity in 314 aa overlap and Escherichia FT coli SW:MIAA_ECOLI (P16384) (316 aa); Fasta score E(): FT 2.2e-27, 35.5% identity in 293 aa overlap. Contains Pfam FT match to entry PF01715 IPPT, IPP transferase." FT /db_xref="GOA:P46811" FT /db_xref="InterPro:IPR018022" FT /db_xref="UniProtKB/Swiss-Prot:P46811" FT /protein_id="CAC31376.1" FT /translation="MRPLAIVGPTGVGKSELALDVIERLGGQVSVEIVNADAMQLYRGM FT DIGTAKLPVAARRGIPHHQLDVLDVTETATVASYQRTAAADIEAIAARGAVPVVVGGSM FT LYVQSLLDDWSFPGTDPAVRVRWEQQLAEVGVVRLHAELARRDLAAAAAILPTDGRRTV FT RALEVVELTGKPFAASAPRIGAPRWDTVIVGLDCDRTILSERLARRIDSMFGQGLVDEV FT RMLLRWGLRDGVTASRALGYAQVLTALDAGGDADHLDEARQQTYLGHRRYARRQRSWFH FT RDHRVHWLDVGTVDRVGVVDDALRVWRNAS" FT misc_feature 163429..164190 FT /note="Pfam match to entry PF01715 IPPT, IPP transferase, FT score 478.50, E-value 5.4e-140" FT RBS 164300..164305 FT misc_feature 164317..165174 FT /note="Pfam match to entry PF01678 DAP_epimerase, FT Diaminopimelate epimerase, score 498.80, E-value 4.3e-146" FT CDS 164317..165207 FT /transl_table=11 FT /gene="dapF" FT /gene_synonym="ML0996" FT /product="diaminopimelate epimerase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae diaminopimelate epimerase (EC 5.1.1.7) (DAP FT epimerase) involved in the biosynthesis of lysine from FT aspartate semialdehyde SW:DAPF_MYCLE (P46814) (296 aa); FT Fasta score E(): 0, 100.0% identity in 296 aa overlap. Also FT highly similar to DAP epimerases from Mycobacterium FT tuberculosis SW:DAPF_MYCTU (O33231) (289 aa); Fasta score FT E(): 0, 76.0% identity in 292 aa overlap and Escherichia FT coli SW:DAPF_ECOLI (P08885) (274 aa); Fasta score E(): FT 4.2e-13, 32.3% identity in 294 aa overlap. Contains Pfam FT match to entry PF01678 DAP_epimerase, Diaminopimelate FT epimerase. Contains PS01326 Diaminopimelate epimerase FT signature." FT /db_xref="GOA:P46814" FT /db_xref="HSSP:1GQZ" FT /db_xref="InterPro:IPR018510" FT /db_xref="UniProtKB/Swiss-Prot:P46814" FT /protein_id="CAC31377.1" FT /translation="MIFAKGHGTQNDFVVLPDVEADVTFTAAQVAALCNRRQGLGADGV FT LRVTTAGAAVTAGVLEHLPDGVSCSDWYMDYRNADGSVAQMCGNGVRVFAHYLRASGLE FT SCDEFVVGSLAGPRLVNVHHVDELNADVTVDMGKANLLGSGGPAFAVTVGGRRFSGVAV FT DVGNPHLACMDPQLSLEELAALDLGAPVHLDRVQFPDGVNIEVLTAPVDGMVQMRVHER FT GVGETRSCGTGTVAAAVAALASAGADTGTLTVRVPGGDVVITITDVTSYLRGPSVLVAH FT GELADAWWYSLARSC" FT misc_feature 164548..164592 FT /note="PS01326 Diaminopimelate epimerase signature" FT CDS 165270..166736 FT /transl_table=11 FT /gene="ML0997" FT /product="possible ATP/GTP-binding protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae HflX protein TR:Q49843 (EMBL:U00019) (518 aa); Fasta FT score E(): 0, 100.0% identity in 488 aa overlap. Also FT highly similar to Mycobacterium tuberculosis hypothetical FT protein TR:O33230 (EMBLZ98209:) (495 aa); Fasta score E(): FT 0, 84.5% identity in 485 aa overlap and Escherichia coli FT GTP-binding protein HflX, located within the hflA (high FT frequency of lysogenization) locus governing lysis and FT lysogeny of bacteriophage lambda, SW:HFLX_ECOLI (P25519) FT (426 aa); Fasta score E(): 0, 38.3% identity in 428 aa FT overlap. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="GOA:Q9CCC0" FT /db_xref="InterPro:IPR002917" FT /db_xref="UniProtKB/TrEMBL:Q9CCC0" FT /protein_id="CAC31378.1" FT /translation="MKYPDSSDRGSADFPDLWDSSDSVPSTGELALHDRLALRRIAGLS FT TELADVSEVEYRQLRLERVVLVGVWTEGSAADNQASMAELATLAETAGSQVLEGLIQRR FT DRPDPSTYIGSGKAAELREVVLATGADTVICDGELSPAQLTALEKAVKVKVIDRTALIL FT DIFAQHATSREGKAQVLLAQMAYMLPRLRGWGESMSRQVGGRAGGSGGGVGLRGPGETK FT IETDRRRIRERMAKLRRDIGAMKQARDTQRSRRLHSDIPSIAIVGYTNAGKSSVLNALT FT GAWVLVQDALFVTLEPTTRHAEFDNGQPFVFTDTVGFVRHLPTQLVEAFRSTLEEVVDA FT DLLLHVVDGSDANPLAQINAVRQVIFEVISDHQDGGVEVPHELLVVNKIDAASALMLAK FT LRHGLPGAVFISARTGDGIDVLRRRIAELVVATDTAVDVVIPYDRGDLVARLHANGRVQ FT QAEHNSNGTRIKARVPVALAACLQEFSADR" FT misc_feature 166068..166091 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 166930..168051 FT /pseudo FT /transl_table=11 FT /gene="ML0998" FT /product="possible acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE13 (Best blastx score 104)" FT CDS complement(168380..168733) FT /pseudo FT /transl_table=11 FT /gene="ML0999" FT /product="possible transposase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1369c (Best blastx score 128). Similar to several other FT Mycobacterium tuberculosis transposases e.g. FT SW:YK87_MYCTU." FT CDS 170353..170596 FT /pseudo FT /transl_table=11 FT /gene="ML1000" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2346c (Best blastx score 132)" FT CDS complement(172599..172874) FT /transl_table=11 FT /gene="ML1001" FT /product="hypothetical protein" FT /note="Doubful CDS. Similar in the N-terminus to FT Mycobacterium tuberculosis TR:O33227 (EMBL:Z98209) (82 aa); FT Fasta score E(): 4.4e-05, 37.5% identity in 88 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCB9" FT /protein_id="CAC31382.1" FT /translation="MPDPVVMPVPCPTSGFTQYSPYYRGAQITLLQQTILAKLNQKYYN FT NRYRVDVEMVLSHTGVEADSAASHTILGLSSSILPPYGCRTKKQRS" FT RBS complement(172876..172880) FT RBS 172911..172915 FT CDS 172919..174982 FT /transl_table=11 FT /gene="ML1002" FT /product="possible conserved membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49837 (EMBL:U00019) (687 FT aa); Fasta score E(): 0, 99.9% identity in 687 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2721c TR:O07219. Contains a possible FT membrane spanning hydrophobic domain." FT /db_xref="InterPro:IPR013207" FT /db_xref="UniProtKB/TrEMBL:Q49837" FT /protein_id="CAC31383.1" FT /translation="MSKRVRRALANTATTAVVTVLLAPVVTASPTGDADDAITAAWHKA FT GGDNSVLGAKKGEVYPLGDGFAQNFASGKLFFTTATGAKLLYGPVLGKYESLGGPVNSD FT LGFPIIDEVPGLAGPDSRVSIFAASDNPVIFWTPDHGAFVVRGALNAAWDKLGSSAGVL FT GVPVADESFDGEVISQKFSGGAVFWNKKSSEFTTEPTALAEQLTGLLVATDPTTAISMA FT WRAAGGVSGPLGPKQGGQHPIGADGIIQDFAGGKVFFSKATGANAVENDILAKYESLGG FT PVGSDLGFPAANEGDGGIVTSSRIAIFSAADKPVIFWTPDHGAFVVRGAMKAAWDKLKG FT PNGKLGVPVADQSVDGNVISQRFIGGKISWNRANNTFTADPANLASLLSGLQVSEQSQP FT SELAMLFHAKKSTGHWWWLVAAVAVLLVIVMFVLLALGWRRRRTAHDIVADSHDHDMDV FT GMDFGYKAAVDGQCTYDAESGTEHPVRDVERGPTVSWLRGAQDATGLAQDARLGPAFGS FT ELPSESEEPLGLEEDDPDAVDTDSMPALSDADFPYAALSDAAHWDADAAEVVATDNSSV FT ATDNSSLLETAADTEVSTGRHAAVDMADAMDASFPGVTVPRMLFRPSPTLRPTIHLPLD FT DPYQVPDGYPIKASPRFGLYYTPASELYHDTLAEVWLANEEIAQVNGFIKAD" FT CDS complement(175021..175728) FT /transl_table=11 FT /gene="lexA" FT /gene_synonym="ML1003" FT /product="LexA, SOS repressor protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae LexA protein TR:Q49848 (EMBL:U00019) (235 aa); Fasta FT score E(): 0, 100.0% identity in 235 aa overlap. Also FT highly similar to many other LexA proteins known to repress FT genes in response to DNA damage, as part of the SOS FT response e.g. from Mycobacterium tuberculosis TR:Q50765 FT (EMBL:X91407) (217 aa); Fasta score E(): 0, 89.4% identity FT in 218 aa overlap and Escherichia coli SW:LEXA_ECOLI FT (P03033) (202 aa); Fasta score E(): 2.3e-10, 33.5% identity FT in 215 aa overlap. Note codon 19 represents an alternative FT possible translational start site. Contains Pfam match to FT entry PF00717 Peptidase_S24, Peptidase family S24. Contains FT Pfam match to entry PF01726 LexA_DNA_bind, LexA DNA binding FT domain." FT /db_xref="GOA:Q49848" FT /db_xref="HSSP:1JHC" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:Q49848" FT /protein_id="CAC31384.1" FT /translation="MSDSTDISGITVDGRLHSMDSGLTERQRTILNVIRASVTSRGYPP FT SIREIADAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVNVRGVEETQAAGPAVLTEV FT AGSDVLPEPTFVPILGRIAAGSPIFAEGTVEDIFPLPRELVGEGTLFLLKVTGDSMVEA FT AICDGDWVVVRQQKVADNGDIVAAMIDGEATVKTFKRAGGQVWLIPHNPAFDPIPGNDA FT TVLGKVVTVIRKI" FT misc_feature complement(175060..175425) FT /note="Pfam match to entry PF00717 Peptidase_S24, Peptidase FT family S24, score 104.50, E-value 2e-27" FT misc_feature complement(175477..175671) FT /note="Pfam match to entry PF01726 LexA_DNA_bind, LexA DNA FT binding domain, score 136.80, E-value 3.8e-37" FT RBS 175996..176000 FT CDS 176008..176502 FT /transl_table=11 FT /gene="ML1004" FT /product="possible conserved membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49846 (EMBL:U00019) (164 FT aa); Fasta score E(): 0, 100.0% identity in 164 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2719c TR:O07218 (EMBL:Z96072) (165 FT aa); Fasta score E(): 1.8e-23, 55.2% identity in 163 aa FT overlap. Contains a possible membrane spanning hydrophobic FT domain." FT /db_xref="GOA:Q49846" FT /db_xref="InterPro:IPR018392" FT /db_xref="UniProtKB/TrEMBL:Q49846" FT /protein_id="CAC31385.1" FT /translation="MLVIYAVPPLIGNVRHPMSRPILGPRCGSGESAGSRRPAPSRSAS FT APMRYSGASVAMLVAPHRGRTVSLAKTIGLALLAGMITLWLGLMADVSQVIDGDATGFV FT THVPNRLAVVRVEAGESLQDVAARVAPDAPVRQVSERIRELNVLDSSMLVAGQTLIAPV FT G" FT CDS 176664..177128 FT /transl_table=11 FT /gene="ML1005" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49844 (EMBL:U00019) (154 FT aa); Fasta score E(): 0, 100.0% identity in 154 aa overlap. FT Also highly similar to a number of other proteins of FT unknown function e.g. Mycobacterium tuberculosis Rv2718c FT TR:O07217 (EMBL:Z96072) (154 aa); Fasta score E(): 0, 92.7% FT identity in 151 aa overlap and Escherichia coli FT SW:YBAD_ECOLI (P25538) (149 aa); Fasta score E(): 9.7e-21, FT 45.6% identity in 147 aa overlap." FT /db_xref="GOA:Q49844" FT /db_xref="InterPro:IPR003796" FT /db_xref="UniProtKB/Swiss-Prot:Q49844" FT /protein_id="CAC31386.1" FT /translation="MHCPFCRHSDSRVIDSRETDEGQAIRRRRSCPECGRRFTTVETAV FT VAVVKRSGVTEPFSRGKVIRGVRRACQGRQVDDDALNLLAQQVEDTVRAAGLPEVPSHE FT VGLAILGPLRELDEVAYLRFASVYRSFSSADDFEREIEALRAHRRVSTSR" FT CDS 177170..177655 FT /transl_table=11 FT /gene="ML1006" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49838 (EMBL:U00019) (138 FT aa); Fasta score E(): 0, 100.0% identity in 138 aa overlap. FT Note this CDS is 23 aa longer than the previously published FT sequence due to the assignment of the translational start FT site. Also highly similar to a number of other proteins of FT unknown function e.g. Mycobacterium tuberculosis Rv2717c FT TR:O07216 (EMBL:Z96072) (164 aa); Fasta score E(): 0, 73.8% FT identity in 164 aa overlap." FT /db_xref="GOA:Q9CCB8" FT /db_xref="InterPro:IPR014878" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCB8" FT /protein_id="CAC31387.1" FT /translation="MPSDLCPDLQALAPLLGSWVGRGMGKYPTIQPFEYLEEVVFSHLD FT RPFLTYTQKTRAITDGKPLHAETGYLRVPQPGHIELVLAHHSDIAEIEVGTYSVTGDLI FT EVELVTTTIGLVPTAKQVTALGRFFRIDGDEFAYSVQMGAVGQPLQDHLVAVLHRKQ" FT CDS complement(177749..178392) FT /pseudo FT /transl_table=11 FT /gene="ML1007" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2716 (Best blastx score 190)" FT CDS complement(178457..179491) FT /pseudo FT /transl_table=11 FT /gene="ML1008" FT /product="possible hydrolase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2715 (Best blastx score 361)" FT CDS complement(179519..180499) FT /transl_table=11 FT /gene="ML1009" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49847 (EMBL:U00019) (326 FT aa); Fasta score E(): 0, 100.0% identity in 326 aa overlap. FT Also highly similar to a number of other proteins of FT unknown function e.g. Mycobacterium tuberculosis Rv2714 FT TR:O07213 (EMBL:Z96072) (324 aa); Fasta score E(): 0, 89.7% FT identity in 320 aa overlap." FT /db_xref="InterPro:IPR008492" FT /db_xref="UniProtKB/TrEMBL:Q49847" FT /protein_id="CAC31390.1" FT /translation="MSHSHYQDPDDEQHYQPGQPGMYVLEFPAPQLLASDGRGPVLIHA FT LEGFSDAGHAIRLAATHLKAALNTELVASFAIDELLDYRSRRPLMTFKTDHFTHYDDPE FT LSLYALRDSVGTPFLLLAGMEPDLKWERFITAVRLLAERLGVRQTISLGTVPMAVPHTR FT PITLTAHSNNGELIADFTPWITEIQVPGSASNLLEYRMGQHGHEVVGFTVHVPHYLTQT FT DYPAAAQALLEQVAKTGALQLPLSALAEAAAEIRAKIDEQVQASTEVAQVVAALERQYD FT AFIDAQENRSLLRRDEDLPSGDELGAEFERFLAQQAEKKRDDDLT" FT CDS complement(180776..181018) FT /transl_table=11 FT /gene="ML1010" FT /product="hypothetical protein" FT /note="function unknown." FT /db_xref="UniProtKB/TrEMBL:Q9CCB7" FT /protein_id="CAC31391.1" FT /translation="MRGSQHKVAARRVHHRACANLHGAAVDEDCTNAGRGPPDPPPARA FT RVSYPAVLARYSAALVRGDMCDKLAVHITSATSLG" FT CDS complement(181058..181480) FT /transl_table=11 FT /gene="ML1011" FT /product="hypothetical protein" FT /note="function unknown." FT /db_xref="UniProtKB/TrEMBL:Q9CCB6" FT /protein_id="CAC31392.1" FT /translation="MCAPAAARCVHRTMPSTTCSARTHHLGDHQTNPMTADPLTHGAPL FT VPLTSPSHANKGNPLAVIPVLASQPIGMLPWAGAVPSESAEPTCDSTAPPPANSGNHLV FT GTRILYGNPTWIYGNPTWIEVELVDLPQVGGRSIIG" FT CDS complement(181548..182968) FT /pseudo FT /transl_table=11 FT /gene="ML1012" FT /product="possible dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2713 (Best blastx score 507)" FT CDS complement(183481..184173) FT /transl_table=11 FT /gene="ML1013" FT /product="iron dependent repressor" FT /note="Highly similar to multiple iron-binding regulatory FT proteins such as Mycobacterium tuberculosis SW:IDER_MYCTU FT (Q50495) (230 aa); Fasta score E(): 0, 90.0% identity in FT 230 aa overlap and Corynebacterium diphtheriae FT SW:DTXR_CORDI (P33120) (226 aa); Fasta score E(): 0, 56.1% FT identity in 230 aa overlap. Contains Pfam match to entry FT PF01325 Fe_dep_repress, Iron dependent repressor." FT /db_xref="GOA:Q9CCB5" FT /db_xref="HSSP:1FX7" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCB5" FT /protein_id="CAC31394.1" FT /translation="MNDLVDTTEMYLRTIYDLEEEGVTPLRARIAERLEQSGPTVSQTV FT SRMERDGLLRVAGNRHLELTTKGRAMAIAVMRKHRLAERLLVDVIGLPWEEVHAEACRW FT EHVMSEDVERRLIKVLNNPTTSPFGNPIPGLLDLGAGPDASAANAKLVRLTELPSGSPV FT AVVVRQLTEHVQDDIDLITRLKDTGVVPNARVTVETSPAGNVIIIIPGHENVTLPHEMA FT HAVKVEKV" FT misc_feature complement(183775..184161) FT /note="Pfam match to entry PF01325 Fe_dep_repress, Iron FT dependent repressor, score 248.00, E-value 1.3e-70" FT RBS complement(184178..184185) FT CDS complement(184330..185289) FT /transl_table=11 FT /gene="ML1014" FT /product="RNA polymerase sigma factor" FT /note="Identical to the previously sequenced Mycobacterium FT leprae RNA polymerase sigma factor TR:Q59531 (EMBL:U15181) FT (319 aa); Fasta score E(): 0, 100.0% identity in 319 aa FT overlap. Also highly similar to many Sigma-70 family FT proteins e.g. Mycobacterium tuberculosis TR:Q59563 FT (EMBL:U10059) (323 aa); Fasta score E(): 0, 96.2% identity FT in 316 aa overlap and Streptomyces coelicolor SW:HRDB_STRCO FT (P18183) (442 aa); Fasta score E(): 0, 60.7% identity in FT 303 aa overlap. Contains a probable helix-turn-helix motif FT at aa 278-299 (Score 1887, SD +5.61) Contains Pfam match to FT entry PF00140 sigma70, Sigma-70 factor. Contains PS00716 FT Sigma-70 factors family signature 2. Contains PS00715 FT Sigma-70 factors family signature 1." FT /note="Highly similar to the C-terminus of ML1022" FT /db_xref="GOA:Q59531" FT /db_xref="HSSP:1KU2" FT /db_xref="InterPro:IPR014284" FT /db_xref="UniProtKB/TrEMBL:Q59531" FT /protein_id="CAC31395.1" FT /translation="MAEATTNRVDSDLDAQSPAADLVRVYLNGIGKTALLNAADEVELA FT KRIEAGLYAEHLLQTRKRFGEGRKRALAAVARDGAAARRHLLEANLRLVVSLAKRYTGR FT GMPLLDLIQEGNLGLIRAMEKFDYTKGFKFSTYATWWIRQAITRGMADQSRTIRLPVHL FT VEQVNKLARIKREMHQNLGREATDEELAAESGIPIEKINDLLEHSRDPVSLDMPVGSEE FT EAPLGDFIEDAEAMSAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLD FT QIGKLFGLSRERVRQIERDVMCKLRNGERADRLRSYAS" FT misc_feature complement(184369..185052) FT /note="Pfam match to entry PF00140 sigma70, Sigma-70 FT factor, score 388.60, E-value 6e-113" FT misc_feature complement(184375..184455) FT /note="PS00716 Sigma-70 factors family signature 2" FT misc_feature complement(184921..184962) FT /note="PS00715 Sigma-70 factors family signature 1" FT RBS complement(185295..185299) FT CDS complement(185456..185875) FT /transl_table=11 FT /gene="ML1015" FT /product="possible conserved membrane protein" FT /note="Almost identical to the previously sequenced FT Mycobacterium leprae hypothetical protein TR:Q49983 FT (EMBL:U15181) (162 aa); Fasta score E(): 0, 100.0% identity FT in 139 aa overlap. Also highly similar to Mycobacterium FT tuberculosis Rv2709 TR:O07210 (EMBL:Z96072) (148 aa); Fasta FT score E(): 0, 70.7% identity in 123 aa overlap. Contains FT possible membrane spanning hydrophobic domains." FT /db_xref="UniProtKB/TrEMBL:Q9CCB4" FT /protein_id="CAC31396.1" FT /translation="MGKLSTAPNRGTTDTFDDNSRPVLITTAAPSYEEERRTRVRKYMT FT LMAFRIPALMLTTVAYSAWHNGLISLLIVAASVPLPWMAVLIANDRPLRRTEEPRRFDS FT RRRRTPLLLTTEQPAFKSLRRPPPKPTSLATDSRS" FT CDS 185903..186226 FT /transl_table=11 FT /gene="ML1016" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49984 (EMBL:U15181) (107 aa); Fasta score E(): FT 0, 99.1% identity in 107 aa overlap. Also highly similar to FT several proteins of undefined function e.g. Mycobacterium FT tuberculosis Rv2707 possible membrane protein TR:O07209 FT (EMBL:Z96072) (82 aa); Fasta score E(): 9.2e-29, 87.8% FT identity in 82 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49984" FT /protein_id="CAC31397.1" FT /translation="MSGFCFSVGRVRRHNVTMLGRHNVTMLGMQTQTIEHTYTDEHVDD FT GTGSDTPKYFHYVKKDKIVESAVMGSHVVALCGEVFPVTRAAKPGSPVCSDCKRVYDML FT KKG" FT CDS complement(186213..187205) FT /transl_table=11 FT /gene="ML1017" FT /product="possible conserved integral membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49985 (EMBL:U15181) (330 aa); Fasta score E(): FT 0, 100.0% identity in 330 aa overlap. Also highly similar FT to several proteins of undefined function e.g. FT Mycobacterium tuberculosis Rv2707 possible membrane protein FT TR:O07208 (EMBL:Z96072) (324 aa); Fasta score E(): 0, 75.4% FT identity in 325 aa overlap." FT /db_xref="GOA:Q49985" FT /db_xref="InterPro:IPR004664" FT /db_xref="UniProtKB/TrEMBL:Q49985" FT /protein_id="CAC31398.1" FT /translation="MSGQVYKPTRQHIWRISLRTLSKSWDDSIFSESAQAAFWSALSLP FT PLVLGMLGSLAYVAPLFGEDTLPTIERRVISMAHSFFSPSVVNEIIEPTISDVNNGARG FT EVVSLGFLISLWAGSSAISAFVDAVVKAHDQTLLRHPVKQRLFALFLYIAMLAFVVATA FT PLVVVGPRKVTKLIPHSWANMLHLGYYPAVIVSLLVAVMILYRVALPIPLPTHRLVFGA FT ILATAVFVITTLGLRIYLKWITGTGYTYGALTTPIAFLLFAFFGGFAIMLGAEFNASIQ FT EKFPAPKTHTHRLHNWLTSRLHTDPGRNTVTTQTTQHRSGRAAELINPS" FT CDS complement(187210..187425) FT /transl_table=11 FT /gene="ML1018" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCB3" FT /protein_id="CAC31399.1" FT /translation="MAYDDPFMQTESTYWPTLPAGAQQYTSSTKHPVDGDRAEATVDMA FT GIPCRIMPQRHRNEQHSVAGYASSHR" FT CDS 187881..188089 FT /pseudo FT /transl_table=11 FT /gene="ML1019" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2706c (Best blastx score 69)" FT CDS 188114..188447 FT /pseudo FT /transl_table=11 FT /gene="ML1020" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2705c (Best blastx score 206)" FT CDS complement(188440..188858) FT /pseudo FT /transl_table=11 FT /gene="ML1021" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2704 (Best blastx score 153)" FT CDS complement(189185..190909) FT /transl_table=11 FT /gene="rpoT" FT /gene_synonym="ML1022" FT /product="RNA polymerase sigma factor" FT /note="Identical to the previously sequenced Mycobacterium FT leprae RNA polymerase sigma factor, rpoT TR:Q59532 FT (EMBL:U15181) (574 aa); Fasta score E(): 0, 99.8% identity FT in 574 aa overlap. Also highly similar to many other FT proposed sigma factors e.g. Mycobacterium tuberculosis SigA FT (RpoD), RNA polymerase sigma factor Rv2703 SW:RPSA_MYCTU FT (Q60162) (528 aa); Fasta score E(): 0, 80.5% identity in FT 533 aa overlap. Contains a probable helix-turn-helix motif FT at aa 533-554 (Score 1603, SD +4.65) Contains Pfam match to FT entry PF00140 sigma70, Sigma-70 factor. Contains PS00716 FT Sigma-70 factors family signature 2. Contains PS00715 FT Sigma-70 factors family signature 1." FT /note="The C-terminus is highly similar to ML1014" FT /db_xref="GOA:Q59532" FT /db_xref="HSSP:1IW7" FT /db_xref="InterPro:IPR014284" FT /db_xref="UniProtKB/TrEMBL:Q59532" FT /protein_id="CAC31403.1" FT /translation="MEQSRRVPPLQWLSAVARPIARVLTLISTPTFDIADTFGYACPNP FT PEVSPTEGVYVVATKTSPATGQPVKRTATKTPATPAKRSTTKAANGSAPTKRATSTASR FT ATKSTTPPKASGASDAAKKARTSVKSVDTKAPSAQDHTTKASAAKDTLNDPEATLNTLD FT SDATADDLDAEPDLDVEPSEDIDIDIEAADLGLDDLEDDDVVTDIEPGETEDGEATAAT FT KTDEASTDDDEEIVEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQI FT GKVALLNAEEEVELAKRIEAGLYATQLMTELSERGTKLPTAQRRDMMWICRDGDRAKNH FT LLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQ FT AITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLE FT IQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSERE FT AGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD" FT misc_feature complement(189224..189907) FT /note="Pfam match to entry PF00140 sigma70, Sigma-70 FT factor, score 464.90, E-value 6.8e-136" FT misc_feature complement(189230..189310) FT /note="PS00716 Sigma-70 factors family signature 2" FT misc_feature complement(189776..189817) FT /note="PS00715 Sigma-70 factors family signature 1" FT CDS complement(190920..191894) FT /transl_table=11 FT /gene="ppgK" FT /gene_synonym="ML1023" FT /product="polyphosphate glucokinase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae polyphosphate glucokinase (EC 2.7.1.63) FT SW:PPGK_MYCLE (Q49988) (324 aa); Fasta score E(): 0, 99.7% FT identity in 324 aa overlap catalysing the phosphorylation FT of glucose thereby generating D-glucose 6-phosphate. Also FT highly similar to Mycobacterium tuberculosis SW:PPGK_MYCTU FT (Q59568) (265 aa); Fasta score E(): 0, 82.8% identity in FT 262 aa overlap. Note the predicted translational start site FT for this CDS maybe incorrect due to the overlap with CDS FT ML1024." FT /db_xref="GOA:Q49988" FT /db_xref="InterPro:IPR000600" FT /db_xref="UniProtKB/Swiss-Prot:Q49988" FT /protein_id="CAC31404.1" FT /translation="MIRLRSAAARDRCQVLSLAYRITVAGRCQTVSPHHRQAKVSEQPS FT LAKEIAITSTDATADTPRTSPPSDTAGTTSRHRGFGIDIGGSSIKGGIVDLDIGQLIGD FT RIKLLTPQPATPLAVAKTIAEVVNAFGWTAPLGVTYPGVVTQGVVRTAANVDDSWIGTN FT ARDIISAELNSQEVTILNDADAAGLAEGRYGAGKNNSGLIVLLTFGTGIGSAVIHNGKL FT IPNTEFGHLEVDGKEAEQRAASSVKDKYKWSYRTWAKQVTRVLVAIENAMCPDLFIAGG FT GISRKADRWIPLLENRTPMVAAALQNTAGIVGAAMASTADVTH" FT CDS 191843..192718 FT /transl_table=11 FT /gene="suhB" FT /gene_synonym="ML1024" FT /product="putative inositol monophosphatase." FT /note="Identical to the previously sequenced Mycobacterium FT leprae extragenic suppressor protein SuhB homologue FT SW:SUHB_MYCLE (P46813) (291 aa); Fasta score E(): 0, 99.7% FT identity in 291 aa overlap. Also highly similar to many FT other members of the inositol monophosphatase family FT including: Mycobacterium tuberculosis, Rv2701c or ShuB, FT SW:SUHB_MYCTU (O07203) (290 aa); Fasta score E(): 0, 77.6% FT identity in 294 aa overlap and Escherichia coli ShuB, FT SW:SUHB_ECOLI (P22783) (267 aa); Fasta score E(): 1.6e-18, FT 34.7% identity in 239 aa overlap, shown to suppress the FT effect of a temperature-sensitive mutation in E. coli. FT Note the predicted translational start site for this CDS FT maybe incorrect due to the overlap with CDS ML1023. FT Contains Pfam match to entry PF00459 inositol_P, Inositol FT monophosphatase family. Contains PS00629 Inositol FT monophosphatase family signature 1. Contains PS00630 FT Inositol monophosphatase family signature 2." FT /db_xref="GOA:P46813" FT /db_xref="HSSP:1JP4" FT /db_xref="InterPro:IPR000760" FT /db_xref="UniProtKB/Swiss-Prot:P46813" FT /protein_id="CAC31405.1" FT /translation="MTVPDNDPEQLRCVAESLATEAAAFVRCRRAEVFGTDLGAAGGGA FT VRAKSTPTDPVTVVDTETERLLRDRLAQLRPGDSILGEEGGGPADLTATPADTVTWVLD FT PIDGTVNFVYGIPAYAVSVAAQVDGVSVAGAVAEVVAGRVHSAASGLGAHVTDEYGVQV FT LRCSAVDDLSMALLGTGFAYSVVRRAAQAALLAQMLPVVRDVRRIGSAALDLCMVAAGQ FT LDAYYEHEVQVWDCAAGALIAAEAGACVQLPKRNGPVGGAGLVVAAAPGIADALLAALQ FT RFNGLAPILD" FT misc_feature 192080..192598 FT /note="Pfam match to entry PF00459 inositol_P, Inositol FT monophosphatase family, score 266.10, E-value 4.7e-76" FT misc_feature 192143..192184 FT /note="PS00629 Inositol monophosphatase family signature 1" FT misc_feature 192542..192586 FT /note="PS00630 Inositol monophosphatase family signature 2" FT CDS complement(192722..193372) FT /transl_table=11 FT /gene="ML1025" FT /product="possible secreted protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49989 (EMBL:U15181) (216 FT aa); Fasta score E(): 0, 99.5% identity in 216 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2700 TR:O07202 (EMBL:Z96072) (216 FT aa); Fasta score E(): 0, 82.4% identity in 216 aa overlap. FT Contains a possible N-terminal signal sequence." FT /db_xref="UniProtKB/TrEMBL:Q49989" FT /protein_id="CAC31406.1" FT /translation="MVTQITEGTAFDKHGRPFRRRNARPAIFVVVFLVIVAGVSWTIAL FT TRPAKVREPEVCNPPTQSTGSVPTQLGKQVPRTEMTDVTPAKLSDTKVHVLNASGRDGQ FT AADIAGALRDLGFAQPTAANDPMYADTLLNCQGQLRFGTAGQATVAAVWLVAPCTELLH FT DNRTDDSVDLALGTDFTALAHNDDIDAVLASLRPGATEPSDPALLQKIHANSC" FT CDS 193568..193870 FT /transl_table=11 FT /gene="ML1026" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q4998. Also highly similar FT to hypothetical proteins from Mycobacterium tuberculosis FT Rv2699c TR:O07201 (EMBL:Z96072) (100 aa); Fasta score E(): FT 0, 96.0% identity in 100 aa overlap and Streptomyces FT coelicolor TR:O54130 (EMBL:AL021530) (98 aa); Fasta score FT E(): 3.4e-26, 70.4% identity in 98 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49990" FT /protein_id="CAC31407.1" FT /translation="MPTDYDAPRRTETDNVPEDSLEELKARRNEAASAVVDVDESESAE FT SFELPGADLSGEELSVRVIPKQADEFTCSSCFLVQHRSRLASEKNGVMICTDCTA" FT CDS complement(193875..194348) FT /transl_table=11 FT /gene="ML1027" FT /product="possible membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49991 (EMBL:U15181) (157 FT aa); Fasta score E(): 0, 99.4% identity in 157 aa overlap. FT Also highly similar to proteins of unknown function from FT Mycobacterium tuberculosis Rv2698 TR:O07200 (EMBL:Z96072) FT (161 aa); Fasta score E(): 0, 78.9% identity in 161 aa FT overlap and Streptomyces coelicolor TR:O54132 FT (EMBL:AL021530) (154 aa); Fasta score E(): 1.1e-08, 33.6% FT identity in 149 aa overlap. Contains possible membrane FT spanning hydrophobic domains. Contains a probable FT helix-turn-helix motif at aa 87-108 (Score 1009, SD +2.62)" FT /db_xref="UniProtKB/TrEMBL:Q49991" FT /protein_id="CAC31408.1" FT /translation="MSGTPVAPHNVRYRERLWVPWWWWPLAFALASLIAFEVNLSGATL FT PSWLPFAVAAGTLLWLGRVEIQVIADAPLGGSVELWAGNAHLPITAIAQSAAISRSAKS FT AALGRQLDPAAYVLHRAWVGPMILVVLDDPDDPTPYWLVSCRHPERVLSALRS" FT CDS 194374..194838 FT /transl_table=11 FT /gene="dut" FT /gene_synonym="ML1028" FT /product="probable deoxyuridine triphosphatase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae deoxyuridine 5'-triphosphate nucleotidohydrolase (EC FT 3.6.1.23) SW:DUT_MYCLE (Q49992) (155 aa); Fasta score E(): FT 0, 100.0% identity in 154 aa overlap. Also highly similar FT to many other dUTPases, involved in nucleotide metabolism, FT including Mycobacterium tuberculosis SW:DUT_MYCTU (O07199) FT (154 aa); Fasta score E(): 0, 90.3% identity in 154 aa FT overlap and Escherichia coli SW:DUT_ECOLI (P06968) (461 FT aa); BlastP Expect 8.8. Contains Pfam match to entry FT PF00692 dUTPase, dUTPase." FT /db_xref="GOA:Q49992" FT /db_xref="HSSP:1MQ7" FT /db_xref="InterPro:IPR008181" FT /db_xref="UniProtKB/Swiss-Prot:Q49992" FT /protein_id="CAC31409.1" FT /translation="MSTSLAVVRLDPGLPLPSRAHDGDAGVDLYSVEDVKLAPGQRALV FT RTGLAVAIPFGMVGLIHPRSGLAVRVGLSIVNSPGTVDAGYRGEIKVALINLDPVEPLV FT VHRGDRIAQLLVQRVELVELVEVSSFDEAGLAETSRGDGGHGSSGGHASL" FT misc_feature 194407..194820 FT /note="Pfam match to entry PF00692 dUTPase, dUTPase, score FT 103.50, E-value 4.2e-27" FT CDS 194835..195656 FT /transl_table=11 FT /gene="ML1029" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49993 (EMBL:U15181) (273 FT aa); Fasta score E(): 0, 99.6% identity in 273 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2696c TR:O07198 (EMBL:Z96072) (259 FT aa); Fasta score E(): 0, 70.6% identity in 262 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49993" FT /protein_id="CAC31410.1" FT /translation="MTADDDAERSDEDGAAVMATFGKRTGKDGASRTLTEPADPEATEL FT PAASEPDSEEVDELEGPFDIDDFEDPAVAVLARLDLGSVLIPLPEGSQLQVELTDVGVP FT NAVWVVTANGRFTITAYAAPKTGGLWREVAGELADSLRNDSAKVTVKDGPWGREVVGTN FT TGVVRFIGVDGYRWMIRCVVNGPLETIDVLSEEARAALADTVVRRGDTPLPVRTPLPVQ FT LPEQMAEQLREAAVAQQSAQHADARQQSRELAPRRGAAGSAMQQLHNTTGG" FT CDS complement(195701..196399) FT /transl_table=11 FT /gene="ML1030" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49994 (EMBL:U15181) (232 FT aa); Fasta score E(): 0, 99.6% identity in 232 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2695 TR:O07197 (EMBL:Z96072) (235 FT aa); Fasta score E(): 0, 76.5% identity in 230 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49994" FT /protein_id="CAC31411.1" FT /translation="MAVDLRNVTTVLLPGTGSDDDYVYRAFSGPLHRVGAAVLTPPPQP FT NRLIDGYLSALDDAARAGPIGVGGVSIGAAVAAAWALAHPERAVAVLAALPAWNGAPES FT APAALAARYSASHLRRDGLAATTLQMQASSPPWLADELARSWCGQWPLLPDAMEEAAAY FT IAPSCAELARLATPLGVAAAVDDPIHPLQVGVDWVTAAPHAALQTVTLNQIGTNAAALG FT TACLAALALT" FT CDS 196608..196934 FT /pseudo FT /transl_table=11 FT /gene="ML1031" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2694c (Best blastx score 124)" FT CDS 197131..197553 FT /pseudo FT /transl_table=11 FT /gene="ML1032" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2693c (Best blastx score 118)" FT CDS complement(197735..198009) FT /pseudo FT /transl_table=11 FT /gene="ML1033" FT /product="putative potassium uptake protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT trkB (Best blastx score 154)" FT CDS 198007..198482 FT /pseudo FT /transl_table=11 FT /gene="ML1034" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2687c (Best blastx score 207)" FT CDS 198510..199220 FT /pseudo FT /transl_table=11 FT /gene="ML1035" FT /product="possible membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2686c (Best blastx score 229)" FT CDS complement(199237..200526) FT /transl_table=11 FT /gene="ML1036" FT /product="probable membrane transport protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable membrane transport protein SW:AG45_MYCLE FT (P46838) (429 aa); Fasta score E(): 0, 99.8% identity in FT 429 aa overlap. Also highly similar to Mycobacterium FT tuberculosis probable integral-membrane transport protein FT SW:YQ84_MYCTU (Z96072) (429 aa); Fasta score E(): 0, 74.3% FT identity in 428 aa overlap and Escherichia coli arsenical FT pump membrane protein SW:ARSB_ECOLI (P37310) (429 aa); FT Fasta score E(): 1.2e-17, 23.2% identity in 435 aa overlap. FT Contains multiple possible membrane spanning hydrophobic FT domains." FT /db_xref="GOA:P46838" FT /db_xref="InterPro:IPR004680" FT /db_xref="UniProtKB/Swiss-Prot:P46838" FT /protein_id="CAC31417.1" FT /translation="MSVIAITVFIVTYALIASDRVNKTLAALTGAAIVVTLPIINSEDV FT FYSHETGIDWEVIFLLLSMMIIVSVLRQTGVFEYVAIWTAKRSHGSPLRILLLLVLVMA FT LGSALLDNVTTVLLIAPVTLLVCERLTINAAPFLMAEVFASNIGGAATLVGDPPNIIIA FT SRAGFSFNDFLIHLTPIVIIVTVVLSALLPRLFRGAFAVDPERVADIMSLNEREAIRDR FT WLLIKCGVVLLLVFVAFIAHPVLHTGPSLVGMLGAGILIVISKLERSDYLSSVKWETLL FT FFAGLFIMVGALVKTDVVNQLARATTTLTGGHELLTVVLTLGVSTLVSSIIDNIPYVAT FT MTPIVSELVASMPDQSHTDILWWALALGADFGGNLTAVGASANVVMLEIAKSAGTPISF FT WEFTRKGIAVTVISIALAGIYLWLRYLVMS" FT CDS complement(200579..201133) FT /transl_table=11 FT /gene="ML1037" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49999 (EMBL:U15181) (184 FT aa); Fasta score E(): 0, 99.5% identity in 184 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2683 TR:O07185 (EMBL:Z96072) (165 FT aa); Fasta score E(): 0, 73.8% identity in 164 aa overlap. FT Contains 2 Pfam matches to entry PF00571 CBS, CBS domain." FT /db_xref="InterPro:IPR000644" FT /db_xref="UniProtKB/TrEMBL:Q49999" FT /protein_id="CAC31418.1" FT /translation="MSHEYWSTAVSCNPGIHHIVRLDVAHTPRTTQTYRHSMLAEDIAE FT DFPAISINSSALDAARMLAEHGLPGLLVTDMSDKPYAVLPASQVVRFIVPRYIQDDPSL FT AGVLNESTADQAAEKLSSKKVRDVLPDHLVNVSPVNADDTIIEVAATMSRQRSPLLAVV FT KGGQLLGVITASRLLRAALKH" FT misc_feature complement(200588..200746) FT /note="Pfam match to entry PF00571 CBS, CBS domain, score FT 31.90, E-value 1.5e-05" FT misc_feature complement(200852..201013) FT /note="Pfam match to entry PF00571 CBS, CBS domain, score FT 27.80, E-value 0.00025" FT CDS 201215..203146 FT /transl_table=11 FT /gene="dxs" FT /gene_synonym="ML1038" FT /product="1-deoxy-D-xylulose 5-phosphate synthase (DXP FT synthase)" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable 1-deoxyxylulose-5-phosphate synthase (DXP FT synthase) SW:DXS_MYCL (Q50000) (643 aa); Fasta score E(): FT 0, 100.0% identity in 643 aa overlapE. Also highly similar FT to many members of the transketolase family including DXP FT synthases from Mycobacterium tuberculosis Rv2682c FT SW:DXS_MYCTU (O07184) (638 aa); Fasta score E(): 0, 86.4% FT identity in 632 aa overlap and Escherichia coli FT SW:DXS_ECOLI (P77488) (619 aa); Fasta score E(): 0, 39.2% FT identity in 625 aa overlap. Contains PS00801 Transketolase FT signature 1. Contains PS00802 Transketolase signature 2." FT /db_xref="GOA:Q50000" FT /db_xref="InterPro:IPR005475" FT /db_xref="UniProtKB/Swiss-Prot:Q50000" FT /protein_id="CAC31419.1" FT /translation="MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNL FT GVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAGLSGYPSRAES FT EHDWVESSHASTALSYADGLAKAFELAGNRNRHVVAVVGDGALTGGMCWEALNNIAATP FT RPVVIVVNDNGRSYAPTIGGVADHLATLRLQPAYERLLEKGRDALHSLPLIGQIAYRFM FT HSVKAGIKDSLSPQLLFTDLGLKYVGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKG FT MGYPPAEADQAEQMHTCGVMDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAA FT MPGPTGLTAFGQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYSTFLNRAFDQIM FT MDVALHKLPVTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRVAAPRDAIRLREELGE FT ALDVDDGPTAIRFPKGDVCEDIPALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALA FT VAKRLHNQGIGVTVIDPRWVLPVCDGVLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQ FT VEIDTPCRDVGLPQEFYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQY FT GPRSSQTM" FT misc_feature 201293..201352 FT /note="PS00801 Transketolase signature 1" FT misc_feature 202472..202522 FT /note="PS00802 Transketolase signature 2" FT CDS 203549..205226 FT /pseudo FT /transl_table=11 FT /gene="ML1039" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3727 (Best blastx score 386)" FT stem_loop 204301..204350 FT /note="possible stem loop structure with 100% identity over FT 48 bases and a loop of 2 bases" FT CDS complement(205247..206536) FT /transl_table=11 FT /gene="ML1040" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q50004 (EMBL:U15181) (429 FT aa); Fasta score E(): 0, 100.0% identity in 429 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv2681 TR:O07183 (EMBL:Z96072) (438 FT aa); Fasta score E(): 0, 77.4% identity in 416 aa overlap. FT The predicted product of this CDS is also weakly similar to FT several nucleases e.g. Escherichia coli SW:RND_ECOLI FT (P09155) (375 aa); Fasta score E(): 2.4e-08, 26.7% identity FT in 371 aa overlap ribonuclease D (EC 3.1.26.3). Contains FT Pfam match to entry PF01612 3_5_exonuclease, 3'-5' FT exonuclease." FT /db_xref="GOA:Q50004" FT /db_xref="InterPro:IPR002562" FT /db_xref="UniProtKB/TrEMBL:Q50004" FT /protein_id="CAC31421.1" FT /translation="MREPADDQPGGTEPDPTPLHYPAGGIPNLSVTPSEIAAAAERLDQ FT GYGPFAVDTERASGFRYSNRAYLIQIRRANAGTVLIDPVSHGNDPLTALRPVAEVISKD FT EWILHSADQDLPCLAEVGMRPPALYDTELAGRLAGFDRVNLATMVQRLLGFELAKGHGA FT ADWSKRPLPSDWLNYAALDVELLIELRTAISKVLAEQDKTDWATQEFNYLRTYATRGAT FT TETIPPTRRDRWRRTSGIRRVRDRRALAAVRELWATRDHIAQRRDIAPRRILPDTAIID FT AAIADPKTIDELIAMPVFGGANQRRSAAMWLAALETARQSQDLPDEAEPSNVPPPPGRW FT ARRKPDAAARLEAARAALATVSQRVGVPTENLVSPELVRRLCWDWEVLPESSVDPVNAV FT EEYLRVGQARAWQRELVVTILASAVKSSAG" FT misc_feature complement(205940..206401) FT /note="Pfam match to entry PF01612 3_5_exonuclease, 3'-5' FT exonuclease, score 175.90, E-value 6.6e-49" FT CDS complement(206538..207128) FT /transl_table=11 FT /gene="ML1041" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q50005 (EMBL:U15181) (196 FT aa); Fasta score E(): 0, 99.5% identity in 196 aa overlap. FT Also highly similar to hypothetical proteins from FT Mycobacterium tuberculosis Rv2680 TR:O86317 (EMBL:Z96072) FT (210 aa); Fasta score E(): 0, 83.9% identity in 193 aa FT overlap and Streptomyces coelicolor TR:O69860 FT (EMBL:AL023702) (238 aa); Fasta score E(): 2.9e-25, 43.5% FT identity in 186 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q50005" FT /protein_id="CAC31422.1" FT /translation="MAPVTAAEPTPFREAVAAMNAFTVRPEIELGPIRPPQRLAPYSYA FT LGAQVKHPELDIVPEQSEDNAFGRLILLYDPDGSDAWDGTIRLVAYIQSDLDSREAIDP FT LLPEVAWSWLIEALESRIDHVTALGGTVTATTSVRYGDISGPPRAHQLELRASWTATTP FT EVGVHVKAFCEVLEHAAGLPPAGVIDLGSRSRS" FT RBS complement(207130..207135) FT CDS complement(207289..208087) FT /pseudo FT /transl_table=11 FT /gene="ML1042" FT /product="enoyl-CoA hydratase/isomerase superfamily FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT echA15 (Best blastx score 306)" FT CDS 208217..209290 FT /transl_table=11 FT /gene="hemE" FT /gene_synonym="ML1043" FT /product="uroporphyrinogen decarboxylase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae uroporphyrinogen decarboxylase (EC 4.1.1.37) FT SW:DCUP_MYCLE (P46809) (357 aa); Fasta score E(): 0, 100.0% FT identity in 357 aa overlap. Also highly similar to many FT others including: Mycobacterium tuberculosis SW:DCUP_MYCTU FT (O53231) (357 aa); Fasta score E(): 0, 83.8% identity in FT 357 aa overlap and Bacillus subtilis SW:DCUP_BACSU (P32395) FT (353 aa); Fasta score E(): 0, 43.5% identity in 354 aa FT overlap. Contains Pfam match to entry PF01208 URO-D, FT Uroporphyrinogen decarboxylase (URO-D). Contains PS00907 FT Uroporphyrinogen decarboxylase signature 2. Contains FT PS00906 Uroporphyrinogen decarboxylase signature 1." FT /db_xref="GOA:P46809" FT /db_xref="HSSP:1JPH" FT /db_xref="InterPro:IPR000257" FT /db_xref="UniProtKB/Swiss-Prot:P46809" FT /protein_id="CAC31424.1" FT /translation="MSTRRELLESPYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRER FT YSMLAACFEPEVACEITLQPLRRYDVDAAILFSDIVVPLCAAGIDLDIVPDVGPVIGDP FT VRTATDIHAMKPLEPQAIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGPSRN FT HPRTKAMMLAEPASWHTLMDKLTDLTLGFLLGQIDAGVDAIQVFDSWAGTLSLSDYRQY FT VLPHSARIFATVAEHGVPMTHFGVGTADLLGAMSAAVRSGEKPGHQAVVGVDWRTSLTD FT AAARVEPCTALQGNLDPVVLLAGWPAVERVARTVVDDGRRAVVAGAAGHVFNLGHGVLP FT ETDPGVLSELVSFIHSL" FT misc_feature 208223..209287 FT /note="Pfam match to entry PF01208 URO-D, Uroporphyrinogen FT decarboxylase (URO-D), score 824.40, E-value 4e-244" FT misc_feature 208289..208318 FT /note="PS00906 Uroporphyrinogen decarboxylase signature 1" FT misc_feature 208643..208690 FT /note="PS00907 Uroporphyrinogen decarboxylase signature 2" FT CDS 209287..210642 FT /transl_table=11 FT /gene="hemY" FT /gene_synonym="ML1044" FT /product="protoporphyrinogen oxidase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae protoporphyrinogen oxidase (EC 1.3.3.4) FT SW:PPOX_MYCLE (Q50008) (451 aa); Fasta score E(): 0, 100.0% FT identity in 451 aa overlap. Also highly similar to many FT others including: Mycobacterium tuberculosis SW:PPOX_MYCTU FT (O53230) (426 aa); Fasta score E(): 0, 75.8% identity in FT 429 aa overlap and Bacillus subtilis SW:PPOX_BACSU (P32397) FT (470 aa); Fasta score E(): 2.2e-13, 27.1% identity in 458 FT aa overlap. Contains Pfam match to entry PF01208 URO-D, FT Uroporphyrinogen decarboxylase (URO-D)." FT /db_xref="GOA:Q50008" FT /db_xref="InterPro:IPR002937" FT /db_xref="UniProtKB/Swiss-Prot:Q50008" FT /protein_id="CAC31425.1" FT /translation="MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVL FT RTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSERQRATTDARPLIYSQQRLHSLPPD FT TVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEPGSDPAMAELVADRFGEQAVARLV FT DPLLGGVYAGSAATIGLRAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGY FT QVLIDELVRRSRLQWVAATVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQ FT QIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVASGERLRAKAVTLSSRKWGL FT QGDTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVFDVTVDPVDVCVQRWIDAMPQ FT YGPGHADLVAEVRAGLPPTLVVAGSHMDGIGVPACISAAGRAIEALQAEVAR" FT CDS 210648..211343 FT /transl_table=11 FT /gene="ML1045" FT /product="conserved hypothetical protein" FT /note="Identical, apart from N-terminus, to the previously FT sequenced Mycobacterium leprae hypothetical protein FT TR:Q50009 (EMBL:U15181) (297 aa); Fasta score E(): 0, FT 100.0% identity in 231 aa overlap. Also highly similar to FT proteins of undefined function from Mycobacterium FT tuberculosis Rv2676c TR:P71973 (EMBL:Z80225) (231 aa); FT Fasta score E(): 0, 87.4% identity in 231 aa overlap and FT Streptomyces coelicolor TR:O69830 (EMBL:AL023517) (243 aa); FT Fasta score E(): 0, 61.3% identity in 222 aa overlap." FT /db_xref="InterPro:IPR010644" FT /db_xref="UniProtKB/TrEMBL:Q9CCB2" FT /protein_id="CAC31426.1" FT /translation="MAKLDYNTLNSTIRYLMFSVFSVRPGVLGAQRDTVIHDVRTFFKH FT QEKRGVVVRGLYDIAGLRADADFMIWTHAERVEALQATYADFRRTTKLGRACSPVWSSV FT ALHRPAEFNKSHIPAFLAGEEPGAYICVYPFVRSYDWYLLPDQERRHMLAEHGMAACGY FT KDVRANTVPAFALGDYEWLLAFEAPGLDRIVDLMRELRATEARRHTRAETPFFTGPRVP FT VEQLVNSLP" FT CDS 211366..212072 FT /pseudo FT /transl_table=11 FT /gene="ML1046" FT /product="putative methyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2675c (Best blastx score 246)" FT repeat_region 212166..213036 FT /note="871 bp repeat, 100% identical to region FT 2329118..2329988" FT CDS complement(212194..212938) FT /pseudo FT /transl_table=11 FT /gene="ML1047" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3714c (Best blastx score 211)" FT repeat_region complement(213037..213081) FT /note="45 bp REPLEP-associated sequence" FT repeat_region complement(213037..214053) FT /note="REPLEP region 6, 5'-end most similar to REPLEP 5; FT 3'-end most similar to REPLEP 1, 4 and 5 " FT repeat_region complement(213082..213962) FT /note="Dispersed repeat, REPLEP, copy 6" FT CDS complement(214207..215448) FT /pseudo FT /transl_table=11 FT /gene="ML1048" FT /product="transposase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2885c (Best blastx score 388)" FT CDS complement(215472..216054) FT /pseudo FT /transl_table=11 FT /gene="ML1049" FT /product="resolvase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT resolvase Rv0605 (Best blastx score 351)" FT CDS 216310..217032 FT /pseudo FT /transl_table=11 FT /gene="ML1050" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1191 (Best blastx score 177)" FT CDS 217109..218539 FT /transl_table=11 FT /gene="xclC" FT /gene_synonym="ML1051" FT /product="acyl-CoA synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae XclC TR:Q50017 (EMBL:U15181) (476 aa); Fasta score FT E(): 0, 99.8% identity in 476 aa overlap. Also highly FT similar to many others including: Mycobacterium FT tuberculosis acyl-CoA synthase Rv1193 fadD36 TR:O05295 FT (EMBL:Z93777) (473 aa); Fasta score E(): 0, 81.3% identity FT in 476 aa overlap and Escherichia coli FT long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) FT SW:LCFA_ECOLI (P29212) (561 aa); Fasta score E(): 1.3e-28, FT 31.7% identity in 378 aa overlap. Contains Pfam match to FT entry PF00501 AMP-binding, AMP-binding enzyme. Contains FT PS00455 Putative AMP-binding domain signature. Contains FT PS00038 Myc-type, 'helix-loop-helix' dimerization domain FT signature." FT /db_xref="GOA:Q50017" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q50017" FT /protein_id="CAC31432.1" FT /translation="MLLASLNPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGG FT ARLVAVLATPTASTVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSA FT DSAPDGLPHIPVQLDARSWNRYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDA FT LAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGG FT SLYFGVPTVWSRLVADEAVARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYGST FT ESLITLSTLADGERRAGWVGLPLAGVQTRLVDESGGPVPYDGETVGRLQVRSPTMFGGY FT LNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALL FT GHPDVREVAVVGLPDEDLGQRIVAFVVGAEALDADELINYVAQQLSIHKRPREVRFVDA FT LPRNAMGKVLKKQLLFEG" FT misc_feature 217190..217237 FT /note="PS00038 Myc-type, 'helix-loop-helix' dimerization FT domain signature" FT misc_feature 217190..218335 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 65.80, E-value 4.4e-19" FT misc_feature 217517..217552 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(218562..219827) FT /transl_table=11 FT /gene="ML1052" FT /product="conserved hypothetical protein" FT /note="Previously sequenced Mycobacterium leprae FT hypothetical protein TR:Q50018 (EMBL:U15181) (517 aa); FT Fasta score E(): 0, 100.0% identity in 421 aa overlap. Also FT highly similar to several hypothetical proteins from FT Mycobacterium tuberculosis e.g. Rv1194c TR:O05296 FT (EMBL:Z93777) (421 aa); Fasta score E(): 0, 70.1% identity FT in 421 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCB1" FT /protein_id="CAC31433.1" FT /translation="MARQHPSPRVRELIREGARIALNPTQEWIDQLDRATFAANPAIAN FT DPVLAKVVRRASRAHLVHWATANLRDPGAPVPAHLGPEPLTMARDLVRRGRDVLALDIY FT RVGQYTAWRRWMEIAFTLTSDPQELREILNVSAQSINEYVAATLEAIATHMQLERDELT FT RSTHAERLEVVDLILEGAPVTQERAEARLGYRLGLTHTAAVIWSDDLDGDHGYLDQAAE FT AFSHVVESTQQLIVVASAATRWVWLADALALDVPEVQKALLNLSKARVAIGTSSAGIEG FT FRRSHLEALTAQRTLARLKSHQQVAFFADVQLVSLITQNPEDAKEFITSTLGDFESASP FT ALQQTLLTFINEQCNASRAAKRLFTHRNTLLRRIESAEKLLPRPLDHTSVHIAVALEAL FT QWRGDQTNTSGPRAGRNDGVPA" FT repeat_region 220160..221222 FT /note="1063 bp repeat. 100% identical to positions FT 1382838..1381770 (1068/1070 bp identical with 1 bp gap)" FT repeat_region 220160..222101 FT /note="100% identical to two adjacent regions separated by FT 619 bp at positions 1382838..1381770 (1068/1070 bp FT identical with 1 bp gap) and 1381151..1380273 (879 bp FT overlap)" FT RBS 220362..220367 FT CDS 220374..220673 FT /transl_table=11 FT /gene="ML1053" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49943 (EMBL:U15180) (99 FT aa); Fasta score E(): 0, 100.0% identity in 99 aa overlap. FT Also highly similar to the whole or just the N-terminus of FT many Mycobacterium tuberculosis PE-family proteins e.g. FT TR:O53938 (EMBL:AL022021) (99 aa); Fasta score E(): 2e-11, FT 46.7% identity in 92 aa overlap and TR:P71664 (EMBL:Z80108) FT (576 aa); Fasta score E(): 3.2e-10, 44.6% identity in 92 aa FT overlap." FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q49943" FT /protein_id="CAC31434.1" FT /translation="MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTEIAPPAA FT DDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAYAGTETANHDSL" FT CDS 220730..221367 FT /pseudo FT /transl_table=11 FT /gene="ML1054" FT /product="possible PPE-family protein (pseudogene)" FT /note="Similar to Mycobacterium leprae PPE-family protein FT TR:Q9Z5K0." FT repeat_region 221223..222101 FT /note="879 bp repeat. 100% identical to FT complement(1380273..1381151)" FT CDS 221433..221735 FT /transl_table=11 FT /gene="ML1055" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49945 (EMBL:U15180) (100 FT aa); Fasta score E(): 0, 100.0% identity in 100 aa overlap. FT Also similar to another Mycobacterium leprae hypothetical FT protein TR:Q9S382 (EMBL:AL049191) (94 aa); Fasta score E(): FT 0, 100.0% identity in 94 aa overlap and several proteins of FT undefined function from Mycobacterium tuberculosis e.g. FT TR:O05299 (EMBL:Z93777) (98 aa); Fasta score E(): 1.7e-20, FT 58.3% identity in 96 aa overlap." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:Q49945" FT /protein_id="CAC31436.1" FT /translation="MTAAHFMTDPQAMRDMARKFDMHAQNVRDESHKMFMSSMDIAGAG FT WSGTAQLTSHDTMGQINQAFRHIVTLLQDVRDQLGTAADRYEHQEENSRKILSGS" FT RBS 221772..221776 FT CDS 221787..222074 FT /transl_table=11 FT /gene="ML1056" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49946 (EMBL:U15180) (95 FT aa); Fasta score E(): 0, 100.0% identity in 95 aa overlap. FT Also highly similar to several proteins of undefined FT function from Mycobacterium tuberculosis e.g. Rv1793 FT TR:O53942 (EMBL:AL022021) (94 aa); Fasta score E(): FT 4.3e-23, 65.2% identity in 92 aa overlap." FT /db_xref="InterPro:IPR009416" FT /db_xref="UniProtKB/Swiss-Prot:Q49946" FT /protein_id="CAC31437.1" FT /translation="MGNINYQFGEIDAHGAAIRAQAAALETTHQAILATVRDAAEFWGG FT QGSTAHEMFIADLGRNFQMIYEQANSHGQKVQRASSSMADTDRSVSSAWS" FT CDS 222249..222602 FT /transl_table=11 FT /gene="ML1057" FT /product="hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49947 (EMBL:U15180) (117 FT aa); Fasta score E(): 0, 99.1% identity in 117 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49947" FT /protein_id="CAC31438.1" FT /translation="MQRRTRWISGRYYAEINSAKMYFGLGSGSMLVDVFPAAEEVVEDT FT VLVLVGDEAAALEQLLGQTADVAGAAKSGPVQPMGDRGSVSPVGQMVRSALRTPTRAFA FT MPSSPAAGSLHLG" FT CDS complement(222693..223646) FT /transl_table=11 FT /gene="ML1058" FT /product="possible tranferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49948 (EMBL:U15180) (317 FT aa); Fasta score E(): 0, 99.7% identity in 317 aa overlap FT and highly similar to Mycobacterium tuberculosis TR:O05302 FT (EMBL:Z93777) (317 aa); Fasta score E(): 0, 84.9% identity FT in 317 aa overlap. The C-terminus of this protein is also FT similar to many different transferases e.g. Haemophilus FT influenzae SW:DAPD_HAEIN (P45284) (275 aa); Fasta score FT E(): 0.00048, 26.7% identity in 131 aa overlap FT 2,3,4,5-tetrahydropyridine-2-carboxylate FT N-succinyltransferase (EC 2.3.1.117)." FT /db_xref="GOA:Q49948" FT /db_xref="InterPro:IPR019875" FT /db_xref="UniProtKB/TrEMBL:Q49948" FT /protein_id="CAC31439.1" FT /translation="MTGTAGGVGIGLATLAADGSILDTWFPAPKLTESGTSVTSQLAMS FT DVPYELAVLTGRDDDRGTETIAVRTVIGSLDEVAADAYDAYLRLHMLSHRLVAPHGLNA FT DGLFGVLTNVVWTSRGPCAIDGFDTVRAQLRRHGPVTIYGVDKFPRMVDYVVPTGVRIA FT NADRVRLGAHLAPGTTVMHEGFVNYNAGTLGASMVEGRISAGVVVGEGSHVGGGASIMG FT TLSGGGTQVISIGKRCLLGANSGLGISLGDDCIVEAGLYVTTGTKVNTPEGKSVKARAL FT SGGSNLLFRRNSVTGAVEVVARDGRGSTLNEALHTN" FT CDS 223700..224764 FT /transl_table=11 FT /gene="dapE" FT /gene_synonym="ML1059" FT /product="succinyl-diaminopimelate desuccinylase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49949 (EMBL:U15180) (400 aa); Fasta score E(): FT 0, 100.0% identity in 354 aa overlap. Also highly similar FT to succinyl-diaminopimelate desuccinylases from FT Mycobacterium tuberculosis Rv1202 TR:O05303 (EMBL:Z93777) FT (354 aa); Fasta score E(): 0, 86.7% identity in 354 aa FT overlap and Corynebacterium glutamicum SW:DAPE_CORG FT (Q59284) (369 aa); Fasta score E(): 0, 56.3% identity in FT 359 aa overlapL. Contains Pfam match to entry PF01546 FT Peptidase_M20, Peptidase family M20/M25/M40. Contains FT PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature FT 1." FT /db_xref="GOA:Q9CCB0" FT /db_xref="InterPro:IPR011650" FT /db_xref="UniProtKB/TrEMBL:Q9CCB0" FT /protein_id="CAC31440.1" FT /translation="MLDLRGDPIELTAALVDIPSESRAEARIADAVETALRAQTAGFEI FT VRNGNAVLARTSLHRPARVLLAGHLDTVPVAGNLPSRCEKDVLHGCGTVDMKSGDAVFL FT HLAATVTEPVHDLTLMFYDCEEIDSAANGLVRIERELPEWLAADVAILGEPTGGYIEAG FT CQGTLRVVINAAGSRAHSARSWLGDNAIHKLGAVLDRLAAYRARTVDIDGCVYREGLSA FT VRVDGGVAGNVIPDAASVTVNYRFAPDRSVAAALRHVHDVFDGLDVQIEQTDAAVGALP FT GLSQPAAKALVEAADGQVRAKYGWTDVSRFAALGVPAVNYGPGDPNLAHRHDERVPVVQ FT ITAAVDMLRRYLGG" FT misc_feature 223733..224617 FT /note="Pfam match to entry PF01546 Peptidase_M20, Peptidase FT family M20/M25/M40, score 208.80, E-value 6e-59" FT misc_feature 223889..223918 FT /note="PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family FT signature 1" FT CDS complement(224793..226253) FT /pseudo FT /transl_table=11 FT /gene="ML1060" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1204c (Best blastx score 256)" FT CDS 226442..227005 FT /transl_table=11 FT /gene="ML1061" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49952 (EMBL:U15180) (187 FT aa); Fasta score E(): 0, 100.0% identity in 187 aa overlap. FT Also highly similar to Mycobacterium tuberculosis TR:O05306 FT (EMBL:Z93777) (187 aa); Fasta score E(): 0, 72.4% identity FT in 174 aa overlap." FT /db_xref="InterPro:IPR005269" FT /db_xref="UniProtKB/TrEMBL:Q49952" FT /protein_id="CAC31442.1" FT /translation="MRSDRGKPNAWAICVFCAAGPMHPELLELAAELGEAIAERGWTLV FT WGGGRVSAMGAVASAAWTRGGRIVGVIPEMLQRREIADTYVGELIVTETMAERKQVLDD FT HADAFIVLPGGLGTLDELFEAWTAGYLGMHRKPIVMLDPWGHYEGLWAWLHGLIDSGYV FT SPVAMERLVVVDQVDAALEACMSV" FT CDS 227056..228573 FT /pseudo FT /transl_table=11 FT /gene="fadD6" FT /gene_synonym="ML1062" FT /product="acyl CoA-ligase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadD6 (Best blastx score 281)" FT CDS 228776..229651 FT /transl_table=11 FT /gene="folP2" FT /gene_synonym="ML1063" FT /product="dihydropteroate synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae dihydropteroate synthase (EC 2.5.1.15) FT SWDHPS_MYCLE:. Also highly similar to dihydropteroate FT synthases from Mycobacterium tuberculosis Rv1207 FT SW:DHP2_MYCTU (O05308) (318 aa); Fasta score E(): 0, 86.2% FT identity in 290 aa overlap and Escherichia coli FT SW:DHPS_ECOLI (P26282) (282 aa); Fasta score E(): 7.2e-24, FT 34.4% identity in 270 aa overlap. Contains Pfam match to FT entry PF00809 DHPS, Dihydropteroate synthase. Contains FT PS00793 Dihydropteroate synthase signature 2. Contains FT PS00792 Dihydropteroate synthase signature 1." FT /note="Similar to ML0224" FT /db_xref="GOA:P0C0X2" FT /db_xref="HSSP:1AD1" FT /db_xref="InterPro:IPR006390" FT /db_xref="UniProtKB/Swiss-Prot:P0C0X2" FT /protein_id="CAC31444.1" FT /translation="MQSMLCGRPVAADRQLIMAIVNRTPDSFYDRGATFSDEAARAAAH FT RAVAEGADVIDVGGVKAGPGQGVDVDTEIARLVPFIEWLRSAYTDLLISVDTWRAEVAR FT LACTAGADLINDSWGGADPAMHEVAAELGAGLVCSHTGGALPRTRPFRVSYGTTTRGVV FT DDVIRQVTAAAERAVAAGVTRDSVLVDPTHDFGKNTFHGLLLLRHVDELVKTGWPVLMS FT LSNKDFVGETLGVGLTERLEGTLAATALAAAAGVRMFRVHEVVATRRVLEMVASIQGTR FT PPTRTVRGLA" FT misc_feature 228824..228871 FT /note="PS00792 Dihydropteroate synthase signature 1" FT misc_feature 228827..229603 FT /note="Pfam match to entry PF00809 DHPS, Dihydropteroate FT synthase, score 457.60, E-value 1e-133" FT misc_feature 228926..228967 FT /note="PS00793 Dihydropteroate synthase signature 2" FT CDS 229648..230628 FT /transl_table=11 FT /gene="ML1064" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49955 (EMBL:U15180) (318 FT aa); Fasta score E(): 0, 100.0% identity in 317 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1208 TR:O05309 (EMBL:Z93777) (324 FT aa); Fasta score E(): 0, 79.8% identity in 327 aa overlap." FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q9CCA9" FT /protein_id="CAC31445.1" FT /translation="MTASELIASALAARSGDAWLADRSWSRPAWTIDELVAAKAGRAIS FT VVLPALNEEQTIESVIDSISPLVSDRAGLVDELIVLDSGSTDETEIRAIAAGARVVSCE FT QAMPEVPTRPGKGEALWRSLAVTSGDIVVFVDSDLINPHPMFVPWLVGPLLTGDGIHLV FT KGFYRRPLNSNDAGGSARATGGGRVTELVARPLLASLRPQLGYVLQPLSGEYAATRELL FT TALPFAPGYGVEIGLLVDTFDRLGLDAIAQVNLGVRAHRNRPLAELGAMSRQVIATLLS FT RCGILDSGVGLTQFFVDESDGDGYIRHTWSVSLADRPAMSRLRPR" FT CDS 230644..230988 FT /transl_table=11 FT /gene="ML1065" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49955. Also highly similar FT to Mycobacterium tuberculosis hypothetical protein Rv1209 FT TR:O05310 (EMBL:Z93777) (122 aa); Fasta score E(): 1.3e-27, FT 78.6% identity in 112 aa overlap. Note the N-terminus of FT this protein is rich in the amino acid valine producing a FT possible membrane spanning hydrophobic domain." FT /db_xref="InterPro:IPR019933" FT /db_xref="UniProtKB/TrEMBL:Q49956" FT /protein_id="CAC31446.1" FT /translation="MALVLLYLVVLVLVAIVLFGAASLLFGRGERLPPLPRGTTATVLP FT AHGVTGADVDAVKFTQVLRGYKPSEVDWVLDRLGRELEALRGQLAAIADAEADADVSNV FT PSGDDGQDVT" FT CDS 230985..231563 FT /transl_table=11 FT /gene="tagA" FT /gene_synonym="ML1066" FT /product="DNA-3-methyladenine glycosidase I" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49957 (EMBL:U15180) (192 aa); Fasta score E(): FT 0, 99.5% identity in 192 aa overlap. Also highly similar to FT DNA-3-methyladenine glycosidases from Mycobacterium FT tuberculosis Rv1210 TR:O05311 (EMBL:Z93777) (204 aa); Fasta FT score E(): 0, 80.2% identity in 192 aa overlap and FT Escherichia coli SW:3MG1_ECOLI (P05100) (187 aa); Fasta FT score E(): 1.8e-27, 43.8% identity in 185 aa overlap." FT /db_xref="GOA:Q49957" FT /db_xref="HSSP:1NKU" FT /db_xref="InterPro:IPR005019" FT /db_xref="UniProtKB/TrEMBL:Q49957" FT /protein_id="CAC31447.1" FT /translation="MSDDGLVRCGWADVRSGLHWQLYRNYHDQEWGSPVRCGVALFERM FT SLEAFQSGLSWLLILRKRENFRRAFSGFDIEEVARYTHADVQRLLFDDGIVRNRVKIEA FT TIANARAAAELGSAADLSELLWSFAPQPRSRPADGSEIPSTSAEAKAMARELKRRGFRF FT VGPTTAYALMQATGMVDDHICTCWVPPTR" FT RBS 231769..231772 FT CDS 231777..232004 FT /transl_table=11 FT /gene="ML1067" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49958 (EMBL:U15180) (75 FT aa); Fasta score E(): 1.9e-29, 100.0% identity in 75 aa FT overlap. Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1211 TR:O05312 (EMBL:Z93777) (75 FT aa); Fasta score E(): 1.6e-26, 90.7% identity in 75 aa FT overlap." FT /db_xref="UniProtKB/TrEMBL:Q49958" FT /protein_id="CAC31448.1" FT /translation="MLGAEWVREGGPARVWREHTMAAMKPRTGDGPLEATKEGRGIVMR FT VPLEGGGRLVVELTPDEAAALSDELKGVTS" FT CDS complement(232039..233169) FT /pseudo FT /transl_table=11 FT /gene="ML1068" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1212c (Best blastx score 834)" FT CDS 233349..234563 FT /transl_table=11 FT /gene="glgC" FT /gene_synonym="ML1069" FT /product="probable glucose-1-phosphate adenylyltransferase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae GlgC TR:Q49961 (EMBL:U15180) (419 aa); Fasta score FT E(): 0, 100.0% identity in 404 aa overlap. Also highly FT similar to many glucose-1-phosphate adenylyltransferases FT involved in glycogen biosynthesis e.g. from Mycobacterium FT tuberculosis Rv1213 SW:GLGC_MYCTU (O05314) (404 aa); Fasta FT score E(): 0, 92.6% identity in 404 aa overlap and FT Escherichia coli SW:GLGC_ECOLI (P00584) (430 aa); Fasta FT score E(): 0, 39.6% identity in 407 aa overlap. Contains FT Pfam match to entry PF00483 NTP_transferase, Nucleotidyl FT transferase. Contains PS00809 ADP-glucose pyrophosphorylase FT signature 2. Contains PS00810 ADP-glucose pyrophosphorylase FT signature 3. Contains PS00808 ADP-glucose pyrophosphorylase FT signature 1." FT /db_xref="GOA:Q9CCA8" FT /db_xref="InterPro:IPR005835" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCA8" FT /protein_id="CAC31450.1" FT /translation="MREVPQVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLVDFVL FT SNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRFGPHWYTGSAD FT AIYQSLNLIYDEDPDYLVVFGADHVYRMDPEQMLRFHIGSGAGATVAGIRVPRSDATAF FT GCIDADDSGRIRRFTEKPLKPPGTPDDPDKTFVSMGNYIFTTKVLVDAIRADADDDHSY FT HDMGGDILPRLVDGGMAAVYDFSQNEVPGATDWDRAYWRDVGTLDAFYDAHMDLVSLRP FT VFNLYNKRWPIRGESENLAPAKFVNGGSVQESVVGAGSIISAASVRNSVLSSNVVVDNG FT AIVEGSVIMPGARVGRGAVIRHAILDKNVVVGPGEMVGVDPERDREHFAISAGGVVVVG FT KGVWI" FT misc_feature 233370..234185 FT /note="Pfam match to entry PF00483 NTP_transferase, FT Nucleotidyl transferase, score 324.90, E-value 9.4e-94" FT misc_feature 233385..233444 FT /note="PS00808 ADP-glucose pyrophosphorylase signature 1" FT misc_feature 233640..233666 FT /note="PS00809 ADP-glucose pyrophosphorylase signature 2" FT misc_feature 233934..233966 FT /note="PS00810 ADP-glucose pyrophosphorylase signature 3" FT CDS 234637..235290 FT /transl_table=11 FT /gene="ML1070" FT /product="putative TetR-family transcriptional regulator" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49962 (EMBL:U15180) (217 aa); Fasta score E(): FT 0, 100.0% identity in 217 aa overlap. Also highly similar FT to many proteins of undefined function e.g. Mycobacterium FT tuberculosis possible regulatory protein Rv3855 TR:P96222 FT (EMBL:Z83864) (216 aa); Fasta score E(): 0, 60.4% identity FT in 202 aa overlap. Contains a probable helix-turn-helix FT motif at aa 49-70 (Score 1321, SD +3.69) Contains Pfam FT match to entry PF00440 tetR, Bacterial regulatory proteins, FT tetR family." FT /note="Similar to ML0064" FT /db_xref="GOA:Q49962" FT /db_xref="InterPro:IPR015893" FT /db_xref="UniProtKB/TrEMBL:Q49962" FT /protein_id="CAC31451.1" FT /translation="MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERP FT LGDFSVDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRSAVEALAEQLPADPAA FT VWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWSTVMQQWIDYNTAAIQAERKCG FT VAPDTIPAEDLAVALQLMTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS" FT misc_feature 234733..234873 FT /note="Pfam match to entry PF00440 tetR, Bacterial FT regulatory proteins, tetR family, score 66.90, E-value FT 4.2e-16" FT CDS complement(235298..235645) FT /pseudo FT /transl_table=11 FT /gene="ML1071" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1216c (Best blastx score 244)" FT CDS complement(235874..236692) FT /pseudo FT /transl_table=11 FT /gene="ML1072" FT /product="probable integral membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1217c (Best blastx score 362)" FT CDS complement(236830..237668) FT /pseudo FT /transl_table=11 FT /gene="ML1073" FT /product="probable ABC transmembrane transport protein FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1218c (Best blastx score 278)" FT CDS complement(237768..238309) FT /pseudo FT /transl_table=11 FT /gene="ML1074" FT /product="putative transcriptional regulator (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1219c (Best blastx score 232)" FT CDS complement(238386..239060) FT /transl_table=11 FT /gene="ML1075" FT /product="probable O-methyltransferase" FT /note="Previously sequenced Mycobacterium leprae TR:Q49969 FT (EMBL:U15180) (136 aa); Fasta score E(): 0, 100.0% identity FT in 136 aa overlap. Also highly similar to Mycobacterium FT tuberculosis possible methyltransferase Rv1220c TR:O33219 FT (EMBL:Z98260) (215 aa); Fasta score E(): 0, 85.5% identity FT in 214 aa overlap and Streptomyces mycarofaciens FT O-methyltransferase (EC 2.1.1.-) involved in the synthesis FT of the macrolide antibiotic midecamycin SW:MDMC_STRMY FT (Q00719) (221 aa); Fasta score E(): 2.3e-11, 30.5% identity FT in 223 aa overlap. Contains Pfam match to entry PF01596 FT Methyltransf_3, O-methyltransferase." FT /db_xref="GOA:Q9CCA7" FT /db_xref="InterPro:IPR002935" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCA7" FT /protein_id="CAC31456.1" FT /translation="MYGTGNNAVTPDQAAASRADSLFAHAEGSISEDAILASARERSEE FT IGARAVTPAVGALLSLLTKLSGGKAVAEVGTGAGVSGLWLLSGMSYDGVLTTIDIEPEY FT LRLAKQAFSEAGIGPSRTRLISGRGQDVLTRLADESYDLVFIDADPIDQPAYVVEGVRL FT LRSCGIIVVHRAALGGRAGDPAARDAEVTAVREAARLIAENERLTPALVPLGDGLLAAV FT RE" FT misc_feature complement(238389..238985) FT /note="Pfam match to entry PF01596 Methyltransf_3, FT O-methyltransferase, score 16.80, E-value 3e-10" FT CDS 239340..240131 FT /transl_table=11 FT /gene="sigE" FT /gene_synonym="ML1076" FT /product="ECF subfamily sigma subunit" FT /note="Highly similar to many proposed ECF-family FT RNA-polymerase sigma factors including: Mycobacterium FT tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta FT score E(): 0, 82.1% identity in 252 aa overlap, FT Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); FT Fasta score E(): 0, 80.6% identity in 247 aa overlap and FT Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta FT score E(): 2.9e-16, 35.7% identity in 171 aa overlap. FT Contains a probable helix-turn-helix motif at aa 213-234 FT (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 FT Sigma70_ECF, Sigma-70 factor (ECF subfamily)." FT /db_xref="GOA:Q9CCA6" FT /db_xref="HSSP:1OR7" FT /db_xref="InterPro:IPR013249" FT /db_xref="UniProtKB/TrEMBL:Q9CCA6" FT /protein_id="CAC31457.1" FT /translation="MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITN FT LLSPTIMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARVYWLAY FT RLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMDAL FT PDDYDRVPADEPNPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATL FT GVKLGTVRSRIHRGRQALRDYLLTAHPRDGATTDATHVKSA" FT misc_feature 239640..239804 FT /note="Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 FT factor (ECF subfamily), score 97.30, E-value 3.1e-25" FT CDS 240278..240697 FT /transl_table=11 FT /gene="ML1077" FT /product="conserved hypothetical protein" FT /note="Highly similar to several proteins of undefined FT function e.g. from Mycobacterium avium TR:O05736 FT (EMBL:U87308) (133 aa); Fasta score E(): 0, 71.7% identity FT in 138 aa overlap, Mycobacterium smegmatis TR:O05768 FT (EMBL:U87307) (145 aa); Fasta score E(): 0, 66.2% identity FT in 139 aa overlap and Mycobacterium tuberculosis Rv1222 FT TR:O06290 (EMBL:U87242) (193 aa); Fasta score E(): 0, 70.7% FT identity in 150 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCA5" FT /protein_id="CAC31458.1" FT /translation="MMADRGQVFRRVFSWLPAQFASQNDAPVGAPRRFGSTEHLSVEAI FT AAFVDGELRMNAHLRAAHHISLCAQCAAEVDDQSRTRAALRDSHPIRIPSTLFGLLTAI FT PRCSPDYTSPVSEPFSEGSVSDRFVDGVAREQGKR" FT CDS 240772..242373 FT /transl_table=11 FT /gene="htrA" FT /gene_synonym="ML1078" FT /product="possinble serine protease" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49972 (EMBL:U15180) (533 aa); Fasta score E(): FT 0, 99.8% identity in 533 aa overlap. Also highly similar to FT Mycobacterium tuberculosis possible serine protease HtrA FT TR:O06291 (EMBL:Z98260) (549 aa); Fasta score E(): 0, 81.8% FT identity in 533 aa overlap. The C-terminus of this CDS is FT similar to several proven proteases e.g. Escherichia coli FT SW:HTRA_ECOLI (P09376) (474 aa); Fasta score E(): 2e-26, FT 35.3% identity in 283 aa overlap. Contains a possible FT membrane spanning hydrophobic domain. Contains Pfam match FT to entry PF00595 PDZ, PDZ domain (Also known as DHR or FT GLGF).. Contains Pfam match to entry PF00089 trypsin, FT Trypsin. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="GOA:Q49972" FT /db_xref="HSSP:1KY9" FT /db_xref="InterPro:IPR001940" FT /db_xref="UniProtKB/TrEMBL:Q49972" FT /protein_id="CAC31459.1" FT /translation="MNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHH FT LATRPVARPPVDAASREAFGRPCGFSGSFVAEYVRPQKYRDRSEFRPDDQPADPVLAEA FT FSRPFGSVDSLQRHPIDAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVPHTE FT LGQCGKLGVRDVLFGGRVSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLA FT TTNNTEEPAGRFAKVAAAVADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAA FT NKPSQFKTTVVFNDGKDVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSGKVRVGDEV FT IAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDM FT DSQVIGINTAGKSLSDSASGLSFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAI FT ASGAQVANVKAGSPAQKGGILENDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVR FT DGRHVTLTVKSDPDSS" FT misc_feature 241456..242070 FT /note="Pfam match to entry PF00089 trypsin, Trypsin, score FT 95.30, E-value 2.1e-29" FT misc_feature 241984..242007 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 242077..242325 FT /note="Pfam match to entry PF00595 PDZ, PDZ domain (Also FT known as DHR or GLGF)., score 33.30, E-value 5.5e-06" FT CDS 242373..242735 FT /transl_table=11 FT /gene="ML1079" FT /product="possible secreted protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49973 (EMBL:U15180) (120 FT aa); Fasta score E(): 0, 98.3% identity in 120 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1224 TR:O33220 (EMBL:Z98260) (131 FT aa); Fasta score E(): 0, 74.0% identity in 131 aa overlap. FT Also similar, in parts, to Escherichia coli TatB or MttA2, FT Sec-independent protein translocase, TR:O69415 FT (EMBL:AJ005830) (171 aa); Fasta score E(): 0.00022, 29.8% FT identity in 121 aa overlap. Contains a possible N-terminal FT signal sequence." FT /db_xref="GOA:Q9CCA4" FT /db_xref="InterPro:IPR018448" FT /db_xref="UniProtKB/TrEMBL:Q9CCA4" FT /protein_id="CAC31460.1" FT /translation="MFANIGWGEMLVLVVVGLVVLGPERFPGAIRWTLGALRQTRDYLS FT GVTNQLREDIGPEFDDLRGQFGELQKLRGMTPRAALTKHLLDGDDSLFTGNFDRPAAAK FT QQDRDHHQTPFDTDAT" FT repeat_region complement(242673..243696) FT /note="REPLEP region 7, 3'-end most similar to 3'-end of FT REPLEP 12" FT repeat_region complement(242751..242788) FT /note="38 bp subsequence of 45 bp REPLEP associated FT sequence" FT repeat_region complement(242789..243669) FT /note="Dispersed repeat, REPLEP, copy 7 " FT repeat_region 243670..243698 FT /note="29 bp subsequence of 45 bp REPLEP-associated FT sequence" FT CDS complement(243755..244906) FT /transl_table=11 FT /gene="mrp" FT /gene_synonym="ML1080" FT /product="MRP-family ATP-binding protein" FT /note="Previously sequenced Mycobacterium leprae FT SW:MRP_MYCLE (P53382) (435 aa); Fasta score E(): 0, 100.0% FT identity in 383 aa overlap. Similar to many other FT MRP-family proteins, the function of which is unknown, e.g. FT Mycobacterium tuberculosis Rv1229c SW:MRP_MYCTU (O33225) FT (390 aa); Fasta score E(): 0, 82.1% identity in 374 aa FT overlap and Escherichia coli SW:MRP_ECOLI (P21590) (379 FT aa); Fasta score E(): 8.3e-30, 33.3% identity in 360 aa FT overlap. Contains Pfam match to entry PF01883 DUF59, Domain FT of unknown function. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). Contains PS01215 Mrp family signature." FT /db_xref="GOA:P53382" FT /db_xref="InterPro:IPR000808" FT /db_xref="UniProtKB/Swiss-Prot:P53382" FT /protein_id="CAC31461.1" FT /translation="MSRTDRNAADLKSAVSTALAKVIDPELQRPITELGMVKNIDIEPG FT GNVQVGIYLTIASCPKKSEISKRVTKAIADVPGTAAVEVSLDVMSDEQRTKLRKKLRGD FT AREPMIPFAQPNSLTRVYTVASGKGGVGKSTVTVNLATAIAARGLAVGVLDADIHGHSI FT PRMMGSNQRPIQLESMILPPIVHEVKVISIGQFTEGNTPVIWRGPMLHRALQQFLSDVY FT WGDLDVLMLDLPPGTGDIAISVAQLIPNAEILVVTTPQLAAAEVAERAGSIALQTRQRI FT VGVVENMSGLMMPDGSRLQVFGEGGGQQVAERLSRAVGTDVPLLGQIPLDPALVAAGDS FT GIPIVLNASDSPVGKELLRIADGLSSRQRRLAGVSLGLDPSRR" FT misc_feature complement(244190..244240) FT /note="PS01215 Mrp family signature" FT misc_feature complement(244505..244528) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(244610..244879) FT /note="Pfam match to entry PF01883 DUF59, Domain of unknown FT function, score 22.70, E-value 6.2e-06" FT CDS complement(245006..245560) FT /pseudo FT /transl_table=11 FT /gene="ML1081" FT /product="possible membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1230c (Best blastx score 149)" FT CDS complement(245744..246192) FT /pseudo FT /transl_table=11 FT /gene="ML1082" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1231c (Best blastx score 179)" FT CDS complement(246217..246767) FT /pseudo FT /transl_table=11 FT /gene="ML1083" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1232c (Best blastx score 228)" FT CDS complement(246851..247465) FT /pseudo FT /transl_table=11 FT /gene="ML1084" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1233c (Best blastx score 522)" FT CDS 247769..248296 FT /pseudo FT /transl_table=11 FT /gene="ML1085" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1234 (Best blastx score 132)" FT RBS 248317..248324 FT CDS 248325..249731 FT /transl_table=11 FT /gene="ML1086" FT /product="probable solute-binding transport lipoprotein" FT /note="Previously sequenced Mycobacterium leprae TR:Q49975 FT (EMBL:U15180) (469 aa); Fasta score E(): 0, 100.0% identity FT in 468 aa overlap. Also similar to many solute-binding FT transport proteins e.g. from Mycobacterium tuberculosis FT Rv1235 TR:O31095 (EMBL:AF028830) (468 aa); Fasta score E(): FT 0, 77.6% identity in 469 aa overlap and Escherichia coli FT SW:MALE_ECOLI (P02928) (396 aa); Fasta score E(): 0.00081, FT 23.4% identity in 295 aa overlap. Contains a possible FT N-terminal signal sequence and an appropriately positioned FT Prokaryotic membrane lipoprotein lipid attachment site. FT Contains Pfam match to entry PF01547 SBP_bacterial_1, FT Bacterial extracellular solute-binding protein. Contains FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site." FT /db_xref="GOA:Q9CCA3" FT /db_xref="InterPro:IPR006059" FT /db_xref="UniProtKB/TrEMBL:Q9CCA3" FT /protein_id="CAC31467.1" FT /translation="MVSRRVHRAGTIILAALTLASVVLACGAGGDQLVISFYTPASEDA FT TFTEVARRCTEQFDGRFAIQHVSLPRSPDEQRLQLARRLTGKDRSLDVMAMDVVWTAEF FT AEAGWTLPLSEDPAGLAEPDAIVDTLPGPLATATWKRKLYAAPVTTNTQLLWYRTDLVD FT QPPGDWNGMVAEAARLHAAGEPSWIAVQANQGEGLVVWFNTLLASAGGQVLSEDGRHVT FT LTDTPEHRAATVRALRIIKAVATVPGADPSITRTDEATARLAVEQGKAALEVNWPFVLA FT SMLENAVKGGVAFLPLDRISELAGSINNVGTFVPNDEQFRIAYQATRNVFGFAPYPSVS FT RSEPAKVTIGGLNLAVASTSRHKAEAFEAVRCLRSEQSQQYLSIEGGLPAVRASLYSDP FT AFQDKYPMYTIIRQQLTDAAVRPVTPAYQAVSIRLSAALNPITDIDPEPMADRLAAQVQ FT KAIDGKGLLP" FT misc_feature 248370..248402 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT misc_feature 248742..249596 FT /note="Pfam match to entry PF01547 SBP_bacterial_1, FT Bacterial extracellular solute-binding protein, score FT 193.60, E-value 3e-54" FT CDS 249760..250674 FT /transl_table=11 FT /gene="ML1087" FT /product="probable ABC-transport protein, inner membrane FT component" FT /note="Previously sequenced Mycobacterium leprae MalF FT TR:Q49976 (EMBL:U15180) (310 aa); Fasta score E(): 0, FT 100.0% identity in 304 aa overlap. Also highly similar to FT many putative membrane transport proteins including: FT Mycobacterium tuberculosis probable sugar transport protein FT Rv1236 TR:O50452 (EMBL:AL021006) (307 aa); Fasta score E(): FT 0, 81.8% identity in 292 aa overlap and Thermococcus FT litoralis inner membrane protein MalF TR:O51924 FT (EMBL:AF012836) (300 aa); Fasta score E(): 0, 39.1% FT identity in 279 aa overlap. Contains multiple possible FT membrane spanning hydrophobic domains. Contains Pfam match FT to entry PF00528 BPD_transp, Binding-protein-dependent FT transport systems inner membrane component." FT /db_xref="GOA:Q9CCA2" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q9CCA2" FT /protein_id="CAC31468.1" FT /translation="MTAVVGKSWHVRASSVQPEQRLAFLLVTPAAMLMLVVTAYPIGYA FT VWLSLQRYSLATPNETVFIGLGNYQTILTDPYWWTALAVTLAITVVSVSIEFILGLMLA FT LVMHRTLLGKSLVRIAVLIPYSIVTVVASYSWYYAWTPGTGYLASLLPQGSVPLTEQIP FT SLSIVIIVEVWKTTPFMSLLLLVGLALVPEDLLKAAQMDGAGAWRRLTKIILPIIKPAV FT MVALLFRTLDAFRIFDNIYVLTRGVNNTDSVSILGYDNLFKGFNVGLGSAISVLIFGCV FT ALIAVIFIKVFGVVAPGGDSNGY" FT misc_feature 250318..250545 FT /note="Pfam match to entry PF00528 BPD_transp, FT Binding-protein-dependent transport systems inner membrane FT component, score 38.40, E-value 1.6e-07" FT RBS 250651..250657 FT CDS 250664..251527 FT /transl_table=11 FT /gene="ML1088" FT /product="probable ABC-transport protein, inner membrane FT component" FT /note="Previously sequenced Mycobacterium leprae MalG FT TR:Q49977 (EMBL:U15180) (296 aa); Fasta score E(): 0, FT 100.0% identity in 287 aa overlap. Also highly similar to FT many putative membrane transport proteins including: FT Mycobacterium tuberculosis probable sugar transport protein FT Rv1237 TR:O50453 (EMBL:AL021006) (274 aa); Fasta score E(): FT 0, 89.4% identity in 274 aa overlap and Thermococcus FT litoralis inner membrane protein MalG TR:O51925 FT (EMBL:AF012836) (278 aa); Fasta score E(): 4.1e-31, 35.9% FT identity in 270 aa overlap. Contains multiple possible FT membrane spanning hydrophobic domains. Contains Pfam match FT to entry PF00528 BPD_transp, Binding-protein-dependent FT transport systems inner membrane component." FT /db_xref="GOA:Q9CCA1" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q9CCA1" FT /protein_id="CAC31469.1" FT /translation="MGIEKVKVTAGVRVGARRATIWVIIDTFVVGYALLPVLWILSLSL FT KPASTVKDGKLIPSLVTFDNYRGIFRSDLFSSALINSIGIGLTTTVIAVMFGAMAAYAI FT ARLAFPGKRLLVGTTLLVTMFPAISLVTPLFNIERRVGLFDTWAGLILPYITFALPLAI FT YTLSAFFAEIPWDLEKAAKMDGATSGQAFRKVIVPLAAPGLVTAAILVFIFAWNDLLLA FT LSLTSTKAAITAPVAITNFTGSSQFEEPTGSIAAGAIVITAPIIVFVWIFQRRIVAGLT FT SGAVKG" FT misc_feature 251168..251398 FT /note="Pfam match to entry PF00528 BPD_transp, FT Binding-protein-dependent transport systems inner membrane FT component, score 59.10, E-value 9.8e-14" FT CDS 251532..252710 FT /transl_table=11 FT /gene="ML1089" FT /product="probable ABC-transport protein, ATP-binding FT component" FT /note="Identical to the previously sequenced Mycobacterium FT leprae TR:Q49978 (EMBL:U15180) (392 aa); Fasta score E(): FT 0, 100.0% identity in 392 aa overlap. Also highly similar FT to many ABC-transport proteins including: Mycobacterium FT tuberculosis Rv1238 TR:O50454 (EMBL:AL021006) (393 aa); FT Fasta score E(): 0, 79.9% identity in 389 aa overlap and FT Agrobacterium radiobacter SW:LACK_AGRRD (Q01937) (363 aa); FT Fasta score E(): 0, 53.1% identity in 339 aa overlap FT lactose transport ATP-binding protein. Contains Pfam match FT to entry PF00005 ABC_tran, ABC transporter. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). Contains FT PS00211 ABC transporters family signature." FT /note="Similar to ML1424" FT /db_xref="GOA:Q49978" FT /db_xref="HSSP:1G29" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q49978" FT /protein_id="CAC31470.1" FT /translation="MAEIVLEHVNKNYPNGATAVHDLSITVADGEFLILIGPSGCGKTT FT TLNMIAGLEDISSGELRIDGDRVNEKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLMLA FT KVKKAEIAQKVSETAQILDLTDLLDRKPSQLSGGQRQRVAMGRAIVRHPKAFLMDEPLS FT NLDAKLRVRTRGEIARLQRRLGATTVYVTHDQTEAMTLGDRVVVMRSGVVQQIGTPDEL FT YERPVNLFVAGFIGSPVMNFFPAKLTPNGLTLPLGELNLSRDVQAMIGQHPVPDRVIVG FT VRPEHLTDAKLIDAHQHGTVLTFKVKVDLVESLGADKYIYFTTTGCDVYSAQLDELASE FT LEVRENQFVARVSAESKMAIGESIELAFGTAKIAVFDADSGVNLTVSAPTDA" FT misc_feature 251619..252164 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 200.60, E-value 2.5e-56" FT misc_feature 251640..251663 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 251934..251978 FT /note="PS00211 ABC transporters family signature" FT CDS complement(253339..254448) FT /transl_table=11 FT /gene="ML1090" FT /product="probable membrane transport protein" FT /note="Previously sequenced Mycobacterium leprae TR:Q49979 FT (EMBL:U15180) (373 aa); Fasta score E(): 0, 100.0% identity FT in 369 aa overlap. Highly similar to Mycobacterium FT tuberculosis putative magnesium and cobalt transport FT protein, CorA (Rv1239c) TR:O50455 (EMBL:AL021006) (366 aa); FT Fasta score E(): 0, 79.4% identity in 369 aa overlap. Also FT weakly similar to Haemophilus influenzae SW:CORA_HAEIN FT (P44998) (315 aa); Fasta score E(): 2.8e-07, 24.1% identity FT in 323 aa overlap, CorA transporter. Contains possible FT membrane spanning hydrophobic domains. Contains Pfam match FT to entry PF01544 CorA, CorA-like Mg2+ transporter protein." FT /db_xref="GOA:Q9CCA0" FT /db_xref="InterPro:IPR002523" FT /db_xref="UniProtKB/TrEMBL:Q9CCA0" FT /protein_id="CAC31471.1" FT /translation="MFPGFDPLPEALRPVTKPRLYTPHVHPIFPPLTEPLVDCGVYVGG FT HRLPDKYTTYTAALSRVREIELMGNEGFVWIGLHEPEASHMHNVADVFGLHPLAVEDAV FT HAHQRPKLERYDDTLFLVLKTVNYVPHESVVLARQIVETGEVMIFVGKNFVVTVRHGEH FT GELSEVRKRMDTDPEHLRLGSYAVMHAISDYVVDRYLAVTNLMEGDIDAIEEVAFAPGR FT KLNVEPIYLLKREVIELRRCVAPLSAALQRMQTDNKDLISKELRRYLRDVADHQTEAAD FT QIASYDDMLNSLVQAALARVGMQQNNDMRKMAAWAGIVAMPTMVAAIYGMNFRFMPELN FT WTWSYPLVMAGMTIVCLVLYWQFRNRNWL" FT misc_feature complement(253342..254247) FT /note="Pfam match to entry PF01544 CorA, CorA-like Mg2+ FT transporter protein, score 487.20, E-value 1.3e-142" FT RBS 254658..254662 FT CDS 254671..255660 FT /transl_table=11 FT /gene="mdh" FT /gene_synonym="ML1091" FT /product="malate dehydrogenase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae malate dehydrogenase (EC 1.1.1.37) SW:MDH_MYCLE FT (P50917) (329 aa); Fasta score E(): 0, 99.7% identity in FT 329 aa overlap. Also highly similar to many other malate FT dehydrogenases including: Mycobacterium tuberculosis Rv1240 FT SW:MDH_MYCTU (O54592) (329 aa); Fasta score E(): 0, 89.1% FT identity in 329 aa overlap and Thermus aquaticus FT SW:MDH_THEFL (P10584) (327 aa); Fasta score E(): 0, 63.7% FT identity in 325 aa overlap. Contains Pfam match to entry FT PF00056 ldh, lactate/malate dehydrogenase. Contains PS00687 FT Aldehyde dehydrogenases glutamic acid active site. Contains FT PS00068 Malate dehydrogenase active site signature." FT /db_xref="GOA:P50917" FT /db_xref="HSSP:1BDM" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:P50917" FT /protein_id="CAC31472.1" FT /translation="MSPRPLKVAVTGAAGQIGYSLLFRLASGSLLGLDRPIELRLLEIE FT PALKALEGVVMELDDCAFLLLAGVEIGADPNKVFDGVNLALLVGARPRGPGMERGDLLE FT ANGAIFTAQGKALNAVAAADIRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNR FT AIAQLATKTGSAVTDIRKMTIWGNHSATQYPDVFHAEIGGKNAAEVVGDQAWIEDYFIP FT TVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPEGNWVSMAVVSDGSYGVPEGLI FT SSFPVTTTDGDWTIVRGLGIDDFSRGRIDKSTAELADERMAVKQLGLI" FT misc_feature 254689..255642 FT /note="Pfam match to entry PF00056 ldh, lactate/malate FT dehydrogenase, score 299.00, E-value 5.6e-86" FT misc_feature 255136..255174 FT /note="PS00068 Malate dehydrogenase active site signature" FT misc_feature 255265..255288 FT /note="PS00687 Aldehyde dehydrogenases glutamic acid active FT site" FT CDS complement(255675..256444) FT /pseudo FT /transl_table=11 FT /gene="ML1092" FT /product="PE_PGRS-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT PE_PGRS (Best blastx score 184)" FT CDS 257729..258586 FT /transl_table=11 FT /gene="ML1093" FT /product="lipoprotein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein TR:Q49982 (EMBL:U15180) (227 FT aa); Fasta score E(): 0, 100.0% identity in 227 aa overlap. FT Also highly similar to Mycobacterium tuberculosis FT lipoprotein Rv1244, TR:O50459 (EMBL:AL021006) (286 aa); FT Fasta score E(): 0, 73.5% identity in 287 aa overlap and FT weakly similar to several others e.g. Streptomyces FT coelicolor TR:Q9X832 (EMBL:AL049727) (320 aa); Fasta score FT E(): 2.9, 26.1% identity in 299 aa overlap putative FT secreted substrate-binding protein. Contains a possible FT N-terminal signal sequence and an appropriately positioned FT Prokaryotic membrane lipoprotein lipid attachment site. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /db_xref="GOA:Q9CC99" FT /db_xref="InterPro:IPR007210" FT /db_xref="UniProtKB/TrEMBL:Q9CC99" FT /protein_id="CAC31474.1" FT /translation="MRVGRLAALLLAGVGVFVAGGCATDRGDRHPELVVGSKPDSESTL FT LAAIYVAALRSYGFGARGETGADPMAMLDSGGFTVVPGFTGKVLQILQPRAAVLSAARV FT YRAMVSALPEGIAAGDYTTAAEDKPTLVVTPDTAKAWSGSDLSLVLSHCNELVVGIVAG FT THTPSAVGSCRLPAAREFPDYPTMFAALRAGQLTAGWTTTANPDLPADLIVLTDGKATL FT IQAENVVPLYRRNVLTDRQMLAINEVAGVLDTAALIEMRRQVIRGADSQAIADGWLAEH FT PMGR" FT misc_feature 257762..257794 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(259132..259965) FT /transl_table=11 FT /gene="ML1094" FT /product="short chain alcohol dehydrogenase" FT /note="Highly similar to several Mycobacterium tuberculosis FT putative oxidoreductases e.g. Rv1245c TR:O50460 FT (EMBL:AL021006) (276 aa); Fasta score E(): 0, 78.3% FT identity in 277 aa overlap. Also similar to many others FT including: Pseudomonas paucimobilis SW:LINX_PSEPA (P50198) FT (250 aa); Fasta score E(): 9.3e-17, 35.6% identity in 194 FT aa overlap 2,5-dichloro-2,5-cyclohexadiene-1,4-diol FT dehydrogenase. Contains Pfam match to entry PF00106 FT adh_short, short chain dehydrogenase. Contains PS00061 FT Short-chain dehydrogenases/reductases family signature." FT /db_xref="GOA:Q9CC98" FT /db_xref="HSSP:1FDU" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CC98" FT /protein_id="CAC31475.1" FT /translation="MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQ FT TEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTGDVEVSHF FT KDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFGLFSVPGQAAYNSAKFAVR FT GFTEALREEMALAGRPVNVTTVYPGGIKTAIARNATAAEGLDVSKIASRFDTWVAHTSP FT QHAARIILKAVRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR" FT misc_feature complement(259387..259947) FT /note="Pfam match to entry PF00106 adh_short, short chain FT dehydrogenase, score 203.70, E-value 2.7e-57" FT misc_feature complement(259456..259542) FT /note="PS00061 Short-chain dehydrogenases/reductases family FT signature" FT RBS complement(259972..259975) FT CDS complement(260028..263810) FT /transl_table=11 FT /gene="odhA" FT /gene_synonym="ML1095" FT /product="2-oxoglutarate dehydrogenase, E1 and E2 FT components" FT /note="This CDS appears to constitute the E1 and E2 FT components of the 2-oxoglutarate dehydrogenase complex. The FT N-terminus of this protein is similar to the FT dihydrolipoamide succinyltransferase component E2 and the FT C-terminus is similar to 2-oxoglutarate dehydrogenase FT components E1 e.g. Escherichia coli SW:ODO2_ECOLI (J01619) FT (179 aa); BlastP Expect 3.9 and Escherichia coli FT SW:ODO1_ECOLI (J01619) (179 aa); BlastP Expect 3.9, FT respectively. The predicted product of this CDS is also FT similar, in its entirety, to Corynebacterium glutamicum FT 2-oxoglutarate dehydrogenase (EC 1.2.4.2) TR:P96746 FT (EMBL:D84102) (1257 aa); Fasta score E(): 0, 58.9% identity FT in 1253 aa overlap and Mycobacterium tuberculosis FT 2-oxoglutarate dehydrogenase Rv1248c TR:O50463 FT (EMBL:AL021006) (1214 aa); Fasta score E(): 0, 89.0% FT identity in 1224 aa overlap. Contains Pfam match to entry FT PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases FT acyltransferase (catalytic domain). Contains Pfam match to FT entry PF00676 E1_dehydrog, Dehydrogenase E1 component." FT /db_xref="GOA:Q9CC97" FT /db_xref="HSSP:1E2O" FT /db_xref="InterPro:IPR005475" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC97" FT /protein_id="CAC31476.1" FT /translation="MQKVASVAQCACRTEELRRTAAVANISSPFGQNEWLVEEMYRKFR FT DDPSSVDPSWHEFLVDYNPESTAEPVLTDPTSTDKQPSATPQAKPAAAADPVASRAKPA FT TTPTVANGTAAGSAAAPAKTTTTPPIEGDELQVLRGAAAVVVKNMSASLDVPTATSVRA FT VPAKLMIDNRTVINNQLKRNRGGKISFTHLLGYALVQAVKKFPNINRHYAEIDGKPIAV FT TPAHTNLGLAIDLQGKDGKRSLVVAGIKRCEELRFAQFVTAYEDIVRRARDGKLTAEDF FT AGVTISLTNPGTIGTVHSVPRLMTGQGAIIGVGAMEYPAEFQGASAERIAELGIGKLIT FT LTSTYDHRIIQGAESGDFLRTIHEMVLSDSFWDEIFRELSIPYLPVRWRTDNPDSIVDK FT NARVMELIAAYRNRGHLMADIDPLRLDNTRFRSHPDLDLLTHGLTLWDLDRVFKVNGFG FT GWKYKKLRDVLGLLRDAYCRHIGVEYTHILDPEQQEWLQQRVETKNVKPTVAEQKYILS FT KLNAAEAFETFLHTKYVGQKRFSLEGAESVIPMMDAAIDQCAKHGLDEVVIGMPHRGRL FT NVLANIVGKPYSQIFTEFEGNLNPTLAHSSGDVKYHLGATGLYLQMFGDNDIQVSLTAN FT PSHLEAVDPVLEGLVRAKQDLLNKDTNGNQDEAFSVVPMMLHGDAAFAGQGVVAETLNL FT ANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACVW FT VAKLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYMYDVVDTKRGARKSYTEAL FT IGRGDISLKEAEDALRDYQGQLERVFNEVRDLEKHGVQPSESVESDQMIPAGLSTAVDK FT ALLARIGDAFLAVPEGFTVHPRVQPVLEKRREMAYEGKIDWAFAELLALGSLVAEGKLV FT RLSGQDTKRGTFSQRHSVIIDRHTGEEFTPLQLLANNPDGSPTGGKFLVYNSPLSEYAA FT VGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFINSGEAKWGQLSTVVLLLPHGHE FT GQGPDHTSGRIERFLQLWAEGSMTFAVPSTPSNYFHLLRRHALDGIKRPLIVFTPKSML FT RNKAAVSDIKDFTEIKFRSVLEEPTYEDSIDDRSKVTRVLLTCGKLYYELAARKIKDNR FT DDVAIVRIEQLAPLPRRRLGETLDRYENAKEFFWVQEEPANQGAWPRFGLELPELLPRL FT TGIKRISRRAMSAPSSGSSKVHAVEQQEILDTAFG" FT misc_feature complement(261261..262262) FT /note="Pfam match to entry PF00676 E1_dehydrog, FT Dehydrogenase E1 component, score 169.00, E-value 8.1e-47" FT misc_feature complement(262704..263387) FT /note="Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid FT dehydrogenases acyltransferase (catalytic domain), score FT 10.60, E-value 6.2e-10" FT CDS complement(263932..264606) FT /transl_table=11 FT /gene="ML1096" FT /product="putative membrane protein" FT /note="Highly similar to Mycobacterium tuberculosis Rv1249c FT TR:O50464 (EMBL:AL021006) (262 aa); Fasta score E(): 0, FT 67.3% identity in 223 aa overlap. Contains multiple FT possible membrane spanning hydrophobic domains." FT /db_xref="UniProtKB/TrEMBL:Q9CC96" FT /protein_id="CAC31477.1" FT /translation="MAQVIERSVWIQGPAAEAYVARLRRTHPSASPTEIVAKLEKHYLA FT ALTASGAVVGSVATLPGIGTLAAVSANAGETVFFLEATAVFVLTIASVYGIPANHRERR FT RALVLAVLAGDDTRLTIGELIGPGRTNGGWLLEGMASLPLSTWSQLHTRMLRYAAKRCT FT VRRGALMFGKILPIGIGAAVGGAGNRVVGKKIISNTRNAFGTAPSRWPATLILLPTVHN FT AG" FT CDS 265104..266377 FT /pseudo FT /transl_table=11 FT /gene="ML1097" FT /product="probable drug efflux protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1250 (Best blastx score 225)" FT CDS complement(266648..270106) FT /transl_table=11 FT /gene="ML1098" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1251c TR:O50466 (EMBL:AL021006) FT (1139 aa); Fasta score E(): 0, 75.5% identity in 1141 aa FT overlap. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="GOA:Q9CC95" FT /db_xref="InterPro:IPR019993" FT /db_xref="UniProtKB/TrEMBL:Q9CC95" FT /protein_id="CAC31479.1" FT /translation="MFVTDETIVYSASDLAAASRCEYALLRDFDARLGRGPVVATTEDE FT LFARTSALGADHEQRHLDQLRHEFGDAVAVIGRPAYTYAGFAAAAEATQRAIANRAPAV FT YQAAMFDGRFVGFIDFLVRDGEQYRVVDTKLARSPKVTALLQLAAYADALAHSGVPVAP FT EAELRLGDGMVVSYRICDLIPVYRSQRSLLQRLLDRHYTAGTAVRWQDDEVRSCFRCPQ FT CTEQLRATDDLLLIAGMRISQRSKLLNVGITTIAELADHSGPVPDLSSSALSELTAQAK FT LQVQQRNTGTPQFEIVDPQPLALLPDPDPGDLFFDFEGDPLWTVDGQEWGLEYLFGVLD FT SEISGTFRPLWAHNRVEERKALTEFLKMVTKRRKQRPHMHVYHYAPYEKTALLRLAGRY FT GVCEDEVDELLRSGTLVDLYPLVSKSIRVGAESFSLKALEPLYMGKQLRSGDVTTATDS FT ITCYGRYCELLSAGNFDEAATVLKEIEDYNHYDCRSTRELRNWLLLQAYEAGVVPVGAQ FT PVPEGNTVKDDDELSAILSALSGFTGDVAVGDRTPEQTAIALVAAARGYHRREDKPFWW FT GHFDRLNFPVGEWADNTDVFVADDASIIIDWHTPPRARKPQRRVRLRGRLARGNLGSAV FT FALYDPPAPLAMDVHPGRRAAGRAEVVEADDLSIPTEVVIVERVGNDGNTFHQLPFALT FT PGPPIATTALRDSIESTATTLAASLPQLPRTALIDILLRRIPRTHSGATLPRGTDTVAD FT ITAAVLDLDSSYLAVHGPPGTGKTHTAAHVITQLVSNHSWRIGVVAQSHAAVENLLDGV FT ITAGLDARQVAKKRHDRSAPPWQEIDGNDYPTFIADPMGCVIGGTAWDFANRNRVPPGS FT LDLLVIDEAGQFCLANTIAVAPAAANLMLLGDPQQLPQVSQGTHPEPVNTSALDWLVEG FT QRTLPNERGYFLDRSYRMHPAICAAVSTLSYEGKLHAHTEYTAARRLNEYQPGVHVLAV FT HHQGNSTESPEEAGAITAEIERLLGTPWTDEHGTRPLDVSDILVLAPYNAQVALVRQQL FT MSAGFSGVRVGTVDKFQGGQAPVVFISMTSSSVEVVPRGISFLLNRNRLNVAVSRAQYA FT AVIVRSETLTEYLPATPVGLIDLGAFLTLTTFNGTGRLESRLDKP" FT misc_feature complement(267776..267799) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(270157..270765) FT /transl_table=11 FT /gene="ML1099" FT /product="putative lipoprotein" FT /note="Highly similar to Mycobacterium tuberculosis FT putative lipoprotein SW:LPRE_MYCTU (Q11065) (202 aa); Fasta FT score E(): 0, 71.3% identity in 202 aa overlap. Contains a FT possible N-terminal signal sequence and an appropriately FT positioned Prokaryotic membrane lipoprotein lipid FT attachment site. Contains PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="GOA:Q9CC94" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC94" FT /protein_id="CAC31480.1" FT /translation="MRDVWSLPCRKSLLGVAAVVLVSGTLTGCSSGDSTVAKTPVPPST FT TTGTISTIISSAPSPPFATAAPPTSNTPPDDPCAVNLASPTIARVVSELPRDPRSAQPW FT NPEPLAGNYNECAQLSAVIIKANTNAVNPTTRAVLFHLGRFIPQGVPDTYGFNGIDPAQ FT TTGDTVALTYPSSIDGLATAVRFHWNGNAVELISNIAGG" FT misc_feature complement(270679..270711) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT RBS complement(270769..270775) FT CDS 271263..272632 FT /pseudo FT /transl_table=11 FT /gene="ML1100" FT /product="possible ATP-dependent DNA/RNA helicase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT deaD (Best blastx score 769)" FT CDS 272632..273771 FT /transl_table=11 FT /gene="ML1101" FT /product="possible acyltransferase" FT /note="Similar to several acyltransferases including: FT Streptomyces thermotolerans macrolide antibiotics FT 3-O-acyltransferase TR:Q56074 (EMBLD30759:) (389 aa); Fasta FT score E(): 1.3e-14, 29.4% identity in 377 aa overlap and FT Mycobacterium tuberculosis probable acyltransferase Rv1254 FT TR:Q11064 (EMBL:Z77137) (383 aa); Fasta score E(): 0, 79.6% FT identity in 378 aa overlap. Contains multiple possible FT membrane spanning hydrophobic domains." FT /db_xref="GOA:Q9CC93" FT /db_xref="InterPro:IPR002656" FT /db_xref="UniProtKB/TrEMBL:Q9CC93" FT /protein_id="CAC31482.1" FT /translation="MTLSEERDAQSGLKQVSHVDRVASLTGIRAVAALLIVGTHAAYTT FT GKYTHGYWGLVGARLEIGVPIFFALSGFLLFSPWVKSAATGSPPPSVSRYAWHRVRRIM FT PAYVITVLFAYALYHFRAAGPNPGHSWMGLVRNLTLTQIYTDGYLGSYLHQGLTQMWSL FT AVEVAFYVALPLLAYLLLVLLCQRRWQPRLVLVVLAGMLLISPGWLILVHPDHWFPDGA FT RLWLPTYLAWFLGGMILAVLQVMGVRCYAFGAIPLAIICYFIVSTPIAGAPTTSPASLG FT EALIKVGFYAAIATLAVAPLTLGDLGWYSWLLSSRPMVWLGEISYEIFLIHLVTMEFAM FT VYVVQDHVYTGSMLNLIVATLVLTIPLAWLLHRCTRMRS" FT CDS complement(275354..276450) FT /pseudo FT /transl_table=11 FT /gene="ML1102" FT /product="possible cytochrome P-450 (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT probable cytochrome P-450 Rv1256c (Best blastx score 356)" FT CDS complement(276458..277819) FT /transl_table=11 FT /gene="ML1103" FT /product="possible oxidoreductase subunit" FT /note="Similar to many putative oxidoreductase subunits FT including: Escherichia coli glycolate oxidase subunit GlcD FT SW:GLCD_ECOLI (P52075) (499 aa); Fasta score E(): 0, 38.8% FT identity in 456 aa overlap and Mycobacterium tuberculosis FT probable oxidoreductase Rv1257c TR:Q11061 (EMBL:Z77137) FT (455 aa); Fasta score E(): 0, 85.8% identity in 451 aa FT overlap. Contains Pfam match to entry PF01565 FT FAD_binding_4, FAD binding domain." FT /db_xref="GOA:Q9CC92" FT /db_xref="InterPro:IPR006094" FT /db_xref="UniProtKB/TrEMBL:Q9CC92" FT /protein_id="CAC31484.1" FT /translation="MGVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQP FT RRTDEVQTVLRWASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMRDITVDPVTRTA FT VCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGVTGDYVLG FT IQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEVTLRLLPTQNTSSIVVA FT TFASVQAAVDAVLGVAARLRPAMLEFMDSVAINAVEDTFRMGLDREAAAMLVAGSDELG FT HAGTDEAKLIGAVFAENGATQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGVP FT LPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTERAHRAFGEIMD FT MAVGLGGTITGEHGVGRLKRPWLDDYLGPDVMELNQRIKHALDPYGILNPGAAI" FT misc_feature complement(277205..277807) FT /note="Pfam match to entry PF01565 FAD_binding_4, FAD FT binding domain, score 321.80, E-value 8.1e-93" FT CDS complement(277824..278919) FT /pseudo FT /transl_table=11 FT /gene="ML1104" FT /product="probable multidrug resistance pump (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1258c (Best blastx score 234)" FT CDS 279262..279951 FT /transl_table=11 FT /gene="ML1105" FT /product="conserved hypothetical protein." FT /note="Similar to many proteins of undefined function FT including: Mycobacterium tuberculosis Rv1259 SW:YC59_MYCTU FT (Q11059) (299 aa); Fasta score E(): 0, 85.5% identity in FT 228 aa overlap and Streptomyces coelicolor TR:Q9S2L3 FT (EMBL:AL109732) (237 aa); Fasta score E(): 0, 54.5% FT identity in 231 aa overlap." FT /db_xref="InterPro:IPR005122" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC91" FT /protein_id="CAC31486.1" FT /translation="MLSGGAGSIPELNAQISVCRACPRLVDWREEVAVVKRRAFADQPY FT WGRPVPGWGSEQPRLLIVGLAPAAHGANRTGRMFTGDRSGDQLYAALHRAGLVNLPISM FT DAADGLQANQIRITAPVRCAPPGNAPTQAEWVTCSPWLEAEWRLVSEYVRAIVALGGFA FT WQIVLRLPGVSAMRKPRFSHGVVAQLYAGVRLLGCYHPSQQNMFTGRLTPAMLDDIFRD FT AKKLAGI" FT stem_loop 280327..280369 FT /note="possible stem loop structure with 100% matches over FT 21 bases and a 1 nt loop." FT CDS 280426..280767 FT /transl_table=11 FT /gene="ML1106" FT /product="hypothetical protein" FT /note="unknown function." FT /db_xref="InterPro:IPR011251" FT /db_xref="UniProtKB/TrEMBL:Q9CC90" FT /protein_id="CAC31487.1" FT /translation="MLAENILMAGGVDSIGRISVLDLVPVRTDQSSRHALVATVQLTQT FT ANQRNFSSRLVVEDYSMLSVGATSPPVLITYLAVQTTRIELLGNLGAVSERASFNYTRS FT VSRARIDLG" FT CDS complement(280738..281174) FT /pseudo FT /transl_table=11 FT /gene="ML1107" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1262c (Best blastx score 270)" FT CDS complement(281251..282166) FT /pseudo FT /transl_table=11 FT /gene="ML1108" FT /product="probable aminotransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0075 (Best blastx score 290)" FT CDS 282281..283491 FT /pseudo FT /transl_table=11 FT /gene="ML1109" FT /product="putative amidase AMI2_MYCTU Q11056 (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT amiB2 (Best blastx score 454)" FT CDS 284313..285503 FT /pseudo FT /transl_table=11 FT /gene="ML1110" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0074 (Best blastx score 257)" FT CDS 285578..286609 FT /pseudo FT /transl_table=11 FT /gene="ML1111" FT /product="similar to adenylate cyclases (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1264 (Best blastx score 409)" FT CDS 287170..287430 FT /pseudo FT /transl_table=11 FT /gene="ML1112" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1265 (Best blastx score 242)" FT CDS complement(287737..289626) FT /transl_table=11 FT /gene="ML1113" FT /product="probable ABC transporter, ATP-binding component" FT /note="Highly similar to many proposed ABC transporter FT proteins including: Mycobacterium tuberculosis Rv1272c FT SW:YC72_MYCTU (Q11047) (631 aa); Fasta score E(): 0, 75.4% FT identity in 623 aa overlap and Bacillus subtilis FT hypothetical ABC transporter ATP-binding protein FT SW:YFIC_BACSU (P54719) (604 aa); Fasta score E(): 0, 43.2% FT identity in 532 aa overlap. Contains possible membrane FT spanning hydrophobic domains. Contains Pfam match to entry FT PF00664 ABC_membrane, ABC transporter transmembrane region. FT Contains Pfam match to entry PF00005 ABC_tran, ABC FT transporter. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00211 ABC transporters family FT signature." FT /note="Similar to the adjoining CDS Rv1244" FT /db_xref="GOA:Q9CC89" FT /db_xref="HSSP:1MT0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q9CC89" FT /protein_id="CAC31494.1" FT /translation="MTMATAPATRSCDFYCTIRRLLKQLVPQRRLSLTVITLGITGTAI FT GIIVPWVLGHTTDLLFNGVIGRQLPKGISKTQAVAAARTRGDNALADLLSGMNLVPGQG FT VDFVAVGRTLGLALSLYLVYTLLTWAQARLLNVTVQRIMFALRSDVEDKVHRLPLSYCD FT TRQRGELLSRVTNDIDNLQSSLSITLSQLLTSLLTVVAVLVVMVSVSPLLALVALLTVP FT MSLLATRAIAQRSQQLFVAQWTSAGRLNAHIEETYSGLTVVKTFGHQTAAREQFRNVNN FT DVYQASFSAQFFSGLVSPATMFISNLGYVVVAALGGLQVATGHITLGNIQAFIQYVRQF FT NMPLSQVAGIYNTLQSGLASAERVFDLLDEPEELPDPMLALPPPHGQVPRINGRVEFQQ FT VSFAYRTGTPVIDDLSMVVEPGSTVAIVGPTGAGKTTLVNLLMRFYDVDSGQILIDGVD FT ITTVSRHALRSRIGMVLQDAWLFDGTIAENIAYGRPQASEDEVMEAAKAAYVDRFVHTL FT SAGYQTRVSGDGDNISAGEKQLITIARAFLARPQLLILDEATSSIDTRTEALIARATHD FT LLQDRTSFIIAHHLPTIRDADHILVVAAGKIVEQGSHAKLLARRGAYYRMTQA" FT misc_feature complement(287812..288366) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 195.20, E-value 1e-54" FT misc_feature complement(287989..288033) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(288322..288345) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(288595..289533) FT /note="Pfam match to entry PF00664 ABC_membrane, ABC FT transporter transmembrane region., score 192.50, E-value FT 6.6e-54" FT CDS complement(289623..291377) FT /transl_table=11 FT /gene="ML1114" FT /product="probable ABC transporter protein, ATP-binding FT component" FT /note="Highly similar to many proposed ABC transporter FT proteins including: Mycobacterium tuberculosis Rv1273c FT SW:YC73_MYCTU (Q11046) (582 aa); Fasta score E(): 0, 78.4% FT identity in 583 aa overlap and Bacillus subtilis FT hypothetical ABC transporter ATP-binding protein FT SW:YFIB_BACSU (P54718) (573 aa); Fasta score E(): 0, 34.4% FT identity in 569 aa overlap. Contains possible membrane FT spanning hydrophobic domains. Contains Pfam match to entry FT PF00664 ABC_membrane, ABC transporter transmembrane FT region.. Contains Pfam match to entry PF00005 ABC_tran, ABC FT transporter. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00211 ABC transporters family FT signature." FT /note="Similar to the adjoining CDS Rv1243" FT /db_xref="GOA:Q9CC88" FT /db_xref="HSSP:1MV5" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q9CC88" FT /protein_id="CAC31495.1" FT /translation="MLLALLRQYIRPYRRLVAVLMVLQLVSTLASLYLPTINAAIIDDG FT VSKGNTAIIVRLGIVMLAVTGLQALCSVGAVYFGSRTGMSFGRDLRSAMFDHITTFSER FT ETARFGAPTLLTRTTNDVRQIQYLVQISGTVLVTPPIMCIGGIVMAIYQEAALTWLLLV FT SVPILAVTNYWIISHMLPLFRSMQSLIDDINRVMRDQLAGIRVIRAFTRESFERNRFER FT ANIALSNAALNAGNWQALMLPTTALTINVSSVALIWFGGLRIDSGQMQIGSLAAFLTYF FT TQILMAVLMATMALVVLPRASVCAQRITEVLSTRPAVGNPPCPHIPRGKVTGVVRLDGV FT TFTYPGTNHPALQDISFTALPGTTTAVVGSTGSGKSTLVALICRLYDVTAGAVLVDEVD FT VRNYNAERLWSVIGLVPQRCYLFSGTVADNLRYGATPGQVITDDQMWEALHMADAEEFI FT RAHNDGLHMRVAQGGINFSGGQRQRLAIARAIIRHPTIYLFDDAFSALDVHTDSRVSKS FT LREMFRDVTIIVVTQRISTAAQADQVIVVDDGKLAGSGTHESLLADCTIYAEFAYSQSF FT GGGVRDSQ" FT misc_feature complement(289731..290294) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 174.40, E-value 1.8e-48" FT misc_feature complement(289908..289952) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(290250..290273) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(290514..291329) FT /note="Pfam match to entry PF00664 ABC_membrane, ABC FT transporter transmembrane region., score 174.40, E-value FT 1.9e-48" FT RBS 291550..291553 FT CDS 291563..292129 FT /transl_table=11 FT /gene="ML1115" FT /product="possible lipoprotein" FT /note="Highly similar to Mycobacterium tuberculosis FT possible lipoprotein Rv1274 SW:LPRB_MYCTU (Q11045) (185 FT aa); Fasta score E(): 0, 78.2% identity in 188 aa overlap. FT Contains a possible N-terminal signal sequence and an FT appropriately positioned Prokaryotic membrane lipoprotein FT lipid attachment site. Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q9CC87" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC87" FT /protein_id="CAC31496.1" FT /translation="MRCDVRALALAARGLIELMIVIPMVAGCSNAGSNKSVGTISSTPG FT NTEGHHGPMFPRCGGISDQTMSQLTKVTGLTNTARNSVGCQWLAGGGIVGPHFSFSWYR FT GSPIGRERKTEELSRASVDDININGHSGFIAVGNEPSLGDSLCEVGIQFQDDFIEWSVS FT FSQKPFPSPCGIAKELTRQSIANSK" FT misc_feature 291614..291646 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT RBS 292131..292134 FT CDS 292138..292701 FT /transl_table=11 FT /gene="ML1116" FT /product="lipoprotein" FT /note="Highly similar to Mycobacterium tuberculosis FT putative lipoprotein LrpC Rv1275 TR:O86337 (EMBL:Z77137) FT (180 aa); Fasta score E(): 0, 82.7% identity in 179 aa FT overlap. Contains a possible N-terminal signal sequence and FT an appropriately positioned Prokaryotic membrane FT lipoprotein lipid attachment site. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="UniProtKB/TrEMBL:Q9CC86" FT /protein_id="CAC31497.1" FT /translation="MRLSVRGRRSVFAGVAVLVSAALVVTGCSRSIGGTAVKAGSHDVP FT RNNNSQQQYPNLLKECEVLTTDILAKTVGADSLDIQSTFVGAICRWQAANPASLIDITR FT FWFEQGSLANERKVADFLKYKVENRSIAGVDSIVMRPDDPNGACGVASDAAGVVGWWIN FT PQASGIDACGQAIKLMELTLATNS" FT misc_feature 292189..292221 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(292709..293194) FT /transl_table=11 FT /gene="ML1117" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis Rv1276c FT SW:YC76_MYCTU (Q11043) (158 aa); Fasta score E(): 0, 65.4% FT identity in 162 aa overlap." FT /db_xref="GOA:Q9CC85" FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/Swiss-Prot:Q9CC85" FT /protein_id="CAC31498.1" FT /translation="MRHAKSSYPRGFPDHIADHDRRLAPRGVREASLAGGWLRTNVPAI FT EKVLCSTAMRARETLTHSGIEAPVRYTERLYRADPDTVIKEIKAISDEVTTSLIVSHEP FT TISAVALALTGSGTNNDAAQRISTKFPTSGIAVLNVAGRWQHLELESAELVAFHVPR" FT repeat_region complement(293273..294025) FT /note="753 bp repeat, 100% identical to region FT 2655600..2656352" FT CDS complement(293281..294512) FT /pseudo FT /transl_table=11 FT /gene="ML1118" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1128c (Best blastx score 268)" FT RBS 294754..294757 FT CDS 294763..295914 FT /transl_table=11 FT /gene="ML1119" FT /product="hypothetical protein" FT /note="Highly similar, in parts,to Mycobacterium FT tuberculosis hypothetical protein Rv1277 TR:Q50699 FT (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity FT in 383 aa overlap." FT /db_xref="GOA:Q9CC84" FT /db_xref="InterPro:IPR014577" FT /db_xref="UniProtKB/TrEMBL:Q9CC84" FT /protein_id="CAC31500.1" FT /translation="MRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLGALAAEVG FT AEFVVVAGDVFEHNQLAPQVVSQSLEAIRAIGIPVYLLPGNHDPLDASSVYTSALFTAE FT CPDNINVLDRAGVHQVRPGLEIVAAPWRSKAPTTDLVAEMLGGLTADIVTRVLVAHGSI FT DVFDPDRDKPSLIRLAGIDDALAGGAVHYVALGDRHSLTQVGSSGRVWYSGSPEVTNFD FT DIESNSGHVLVVEIDENDPRRPVTVTARHVGHWRFFTLHWQVDNGRDIADLDMNLDQMM FT DKDRSVVRLALTGSLTITDRAVLDACLDRYARLFAWLGLWERRSDLAVIPADGEFTDIG FT IGGFAAAAVDELVATAREGDTESAIDAQAALALLLRLADRGVA" FT RBS 295903..295906 FT CDS 295911..298532 FT /transl_table=11 FT /gene="ML1120" FT /product="conserved hypothetical protein" FT /note="Highly similar to Mycobacterium tuberculosis FT hypothetical protein Rv1278 SW:YC78_MYCTU (Q11042) (875 FT aa); Fasta score E(): 0, 69.5% identity in 872 aa overlap. FT Contains multiple possible coiled-coils. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="UniProtKB/TrEMBL:Q9CC83" FT /protein_id="CAC31501.1" FT /translation="MKLHRLALTNYRGTARREIEFPDRGVILVCGANEIGKSSMIEALD FT LLLEFRDRSTKKEVKQVKPANADIGSEVCAEISSGTYRFVYRKRFNKKCETALTVLAPH FT REQLTGDEAHERVRAMLAETVDNDLWHAQRVLQAASTAAVDLSGCDALSRALDLAAGDH FT AELSGTEPLLIERIEAEYRRYFTSTGRPTGEWAVAISRLSDAETAVGECAAAVAEVDDR FT VRRHAVLTERVAGLAQQRFAAGPRLAVAQAAADKVAVLTRQAREAELVAAAATATNAAA FT VAAHTSRLRLLAEIDTRAVVLAATQDEAQEAVDAVSTMRADAEASDAAVEESTEALMAA FT QQRADIARSTVDQLVDRQEADRLSTRLAKIDAIQGERDLICAELSAVTLTEQLLQRIEN FT AAAIVDRTGEQLKLISAAVEFTATADIEISVGQQRVSLEAGQSWSTTATGPTEVEVLGV FT LTACVIPGATALDAQSKYVAAQEELSVALADGGVVDLAAARCANQRRRELQSSLDQLSA FT ALAGVCGDDQIDQLRARLEQLRDGYPGEPDLLAVDIGSARAELEAAETVRAAVDFEREV FT CRRTAAAANCRLVETSARANFLLKKAETQRAELDQDIDQLAQQRASVSDEDLASAAEAG FT LRAVQIAEQRVAKLTEELVAAEPEAVTAELVAATAAAESLRDQHEDAAGALREISIELS FT VFGTEGRQGKLDTAEAEREHAISQHTQIGRRARAAQLLRSVMARHRDTTRLRYVEPYRT FT ELQRLGRPVFGPTFEVDIDSDLRIRSRTLDGITVPFESLSGGAKEQLGILARFAGATLV FT AKEDNVPVVVDDALGFTDPDRLAKMGEMFDTVGAHGQVIVLTCSPDRYDGFTGAHRIDL FT NV" FT misc_feature 296001..296024 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(299720..301393) FT /transl_table=11 FT /gene="ML1121" FT /product="probable extracellular solute-binding dependent FT transport lipoprotein." FT /note="Similar to several including: Mycobacterium FT tuberculosis extracellular solute-binding Rv1280c FT SW:YC80_MYCTU (Q11041) (591 aa); Fasta score E(): 0, 80.3% FT identity in 548 aa overlap and Escherichia coli putative FT binding protein YddS precursor SW:YDDS_ECOLI (P76128) (516 FT aa); Fasta score E(): 2.3e-10, 22.5% identity in 480 aa FT overlap. Contains a possible N-terminal signal sequence and FT an appropriately positioned Prokaryotic membrane FT lipoprotein lipid attachment site. Contains Pfam match to FT entry PF00496 SBP_bac_5, Bacterial extracellular FT solute-binding proteins, family 5. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q9CC82" FT /db_xref="InterPro:IPR000914" FT /db_xref="UniProtKB/TrEMBL:Q9CC82" FT /protein_id="CAC31502.1" FT /translation="MIMLSRIVAALLVVGLILTGCSASNRLVPSAASNAALGKTSDINP FT QDPATLKDGGNLRLALTDFPANFNILHIDGNNAEVTSMMKATMPRAFIIGTDGSTTVDT FT NYFTSIKLTSTSPQVVTYTINPKAVWSDGTPITWRDIDRQIHANSGKNKAFEIAGTNGC FT ERVASIRPGANDRQAIVTFAQPYAEWRGMFAGNGMLLPATMTATPEAFNKGQLDRPGPS FT AGPFIVSSLDRTTQRIVLTHNPKWWGTPPRLDSITYLVLDDAARLPALQNNTIDATGVG FT TLDQLTTAQRTNGISIRRTPAPRWSHFTFNGAVGSILADQGLRLAVSKGIDRRTIAKVV FT QYGLANNPEPLNNHVYVDGQEGYQDNSGVVGYDPEQAQHELDALGWKLNGQFREKDGRQ FT LVIRYLFYDAQGSREFAQLAQHSLAQIGVKLELQAKAGSGFFTNYVNVGAFDIVQFGWV FT GDAFPLSALTQIYQSDGESNFGKISSPAVDAAIERTLAELDPAKARALANEVDKLLWAE FT GFSLPLTQSPGDVAVRSTLANFGAAGFGDLNYTAIGFMQN" FT misc_feature complement(299732..300688) FT /note="Pfam match to entry PF00496 SBP_bac_5, Bacterial FT extracellular solute-binding proteins, family 5, score FT 61.50, E-value 2.3e-16" FT misc_feature complement(301331..301363) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(301390..303219) FT /transl_table=11 FT /gene="ML1122" FT /product="Probable ABC transport protein, ATP-binding FT component" FT /note="Highly similar to many putative ABC transport FT proteins e.g. Escherichia coli SW:YLIA_ECOLI (P75796) (269 FT aa); BlastP Expect 4.0e-28 Mycobacterium tuberculosis FT Rv1281c SW:YC81_MYCTU (Q11040 (269 aa); BlastP Expect FT 4.0e-28. Note, that the N- and C-termini of this CDS are FT possible duplicates. Contains 2 Pfam matches to entry FT PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 FT ATP/GTP-binding site motif A (P-loop). Contains 2 x PS00211 FT ABC transporters family signature." FT /db_xref="GOA:Q9CC81" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q9CC81" FT /protein_id="CAC31503.1" FT /translation="MSPLLEVTDLAVTFETNGEPVTAVRGISYRINAGEVVAMVGESGS FT GKSAAAMAVVGLLPEYAQVRGSVRLHNTELVGLADKTMSRFRGKAIGTVFQDPMSALTP FT VYTVGDQITEAIKVHQPRVGKKAAHRRAVELLELVGITQPDRRARAFPHELSGGERQRV FT VIATAIANDPDLLICDEPTTALDVTVQAQILEVLKTARDVTGAGVLIITHDLGVVTEFA FT DQALVMYAGRVVESAQVSTLYRERQMPYTVGLLGSVPRLDATQGTRLVPIPGAPPSLAG FT LQQECPFAPRCPLVVDECRLREPELVEVRAGHRTACIRTDQVSGRSAADIYGINTDTRT FT SATSDSSVVVRVRDLVKTYRLTKGVGLRRAIGEIRAVNGVSFELQQGRTLGIVGESGSG FT KSTTLHEILRLAVPQSGSIEVLGIDVATLNRASRRSMRRNIQVVFQDPVASLDPRLPVF FT ELIAEPLHANGFSKNYTQMRVAELLDIVGLRRDDATRYPTEFSGGQKQRIGIARALALQ FT PKILAFDEPVSALDVSIQAGIINLLLDLQDRLGLSYLFVSHDLSVIKHLAHQVAVMLAG FT TIVEQGDSHDVFRNPQHDYTRRLLGAIPRPEVG" FT RBS complement(301397..301401) FT misc_feature complement(301492..302061) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 212.90, E-value 5e-60" FT misc_feature complement(301678..301722) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(302017..302040) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(302527..303120) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 185.80, E-value 6.9e-52" FT misc_feature complement(302713..302757) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(303076..303099) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(303216..304115) FT /transl_table=11 FT /gene="ML1123" FT /product="probable binding-protein dependent transport FT protein" FT /note="Highly similar to many membrane transport proteins FT e.g. Mycobacterium tuberculosis putative peptide transport FT permease Rv1282c SW:YC82_MYCTU (Q10623) (291 aa); Fasta FT score E(): 0, 82.6% identity in 287 aa overlap and FT Escherichia coli SW:OPPC_ECOLI (P77664) (302 aa); Fasta FT score E(): 0, 38.8% identity in 289 aa overlap oligopeptide FT transport system permease protein. Contains multiple FT possible membrane spanning hydrophobic domains. Contains FT Pfam match to entry PF00528 BPD_transp, FT Binding-protein-dependent transport systems inner membrane FT component. Contains PS00402 Binding-protein-dependent FT transport systems inner membrane comp sign.." FT /db_xref="GOA:Q9CC80" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q9CC80" FT /protein_id="CAC31504.1" FT /translation="MTLTEGLSISEKTNFASRKTLVLRRFAHNRTASVSLMLLVLLFVA FT CYLLPSLLPYSYDDLDFNALLQPPNTRHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAL FT ISTSIAATVGSIAGYFGRWRDRVLMWVVDLLLVVPSFVLIAIMSPQTKSSDNIMLLVLL FT LAGFGWMVSSRMVRGMTMSLRKSEFIRAGKYMGVSSRRMIVGHVVPNVASILIIDATLN FT VGSAILAETGLSFLGFGIKPPDVSLGTLIANGTQSATTFPWVFLFPAGVLVVILVCANL FT TGDGLRDAFDPVSKHLRR" FT misc_feature complement(303348..303578) FT /note="Pfam match to entry PF00528 BPD_transp, FT Binding-protein-dependent transport systems inner membrane FT component, score 29.30, E-value 9.1e-05" FT misc_feature complement(303489..303575) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp sign." FT CDS complement(304112..305089) FT /transl_table=11 FT /gene="ML1124" FT /product="probable binding-protein dependent transport FT protein" FT /note="Highly similar to many membrane transport proteins FT e.g. Mycobacterium tuberculosis putative peptide transport FT permease protein Rv1283c SW:YC83_MYCTU (Q10611) (325 aa); FT Fasta score E(): 0, 83.4% identity in 325 aa overlap and FT Bacillus subtilis oligopeptide transport system permease FT SW:APPB_BACSU (P42062) (317 aa); Fasta score E(): 4.5e-27, FT 34.1% identity in 328 aa overlap. Contains possible FT membrane spanning hydrophobic domains and a possible FT N-terminal signal sequence. Contains Pfam match to entry FT PF00528 BPD_transp, Binding-protein-dependent transport FT systems inner membrane component. Contains PS00402 FT Binding-protein-dependent transport systems inner membrane FT comp sign.." FT /db_xref="GOA:Q9CC79" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q9CC79" FT /protein_id="CAC31505.1" FT /translation="MMRFLARRLLNYVVLLALASFLTYCLTSMAFAPLDSLLQRSPHPP FT QAMVDAKAHALGLDKPIPIRYANWASHAIRGDFGTTITGQPVGSTLGRRVGVSLRLLII FT GSLTGTVLGVTAGAWGAIRQYQLSDRVVTLLALLVLSTPTFVIANLLILSALRVNWAFG FT IQLFDYTGETSPGVYGGAWAHVIDRLRHLILPTLTLALVGAAGYSRYQRNAMLDVLSQD FT FIRAARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGALFVEKIFGWHGMGEWM FT VQGVATQDTNIIAAITIFFGTVILLAGLLSDVIYAALDPRVRVS" FT misc_feature complement(304232..304447) FT /note="Pfam match to entry PF00528 BPD_transp, FT Binding-protein-dependent transport systems inner membrane FT component, score 28.60, E-value 0.00014" FT misc_feature complement(304358..304444) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp sign." FT CDS 305487..305648 FT /pseudo FT /transl_table=11 FT /gene="ML1125" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1284 (Best blastx score 190)" FT CDS complement(309374..309917) FT /pseudo FT /transl_table=11 FT /gene="ML1126" FT /product="lipoprotein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lpqQ (Best blastx score 222)" FT tRNA complement(316300..316375) FT /gene="argV" FT /note="tRNA Arg anticodon CCG, Cove score 91.71" FT RBS 316558..316561 FT CDS 316571..318223 FT /transl_table=11 FT /gene="argS" FT /gene_synonym="ML1127" FT /product="arginyl-tRNA synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae arginyl-tRNA synthetase (EC 6.1.1.19) FT (arginine--tRNA ligase) SW:SYR_MYCLE (P45840) (550 aa); FT Fasta score E(): 0, 99.6% identity in 550 aa overlap. Also FT highly similar to many other arginyl-tRNA synthetases FT including: Mycobacterium tuberculosis SW:SYR_MYCTU (Q10609) FT (550 aa); Fasta score E(): 0, 84.9% identity in 550 aa FT overlap and Brevibacterium lactofermentum SW:SYR_BRELA FT (P41253) (550 aa); Fasta score E(): 0, 63.8% identity in FT 550 aa overlap. Contains Pfam match to entry PF00750 FT tRNA-synt_1d, tRNA synthetases class I (R). Contains FT PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature." FT /db_xref="GOA:P45840" FT /db_xref="InterPro:IPR015945" FT /db_xref="UniProtKB/Swiss-Prot:P45840" FT /protein_id="CAC31508.1" FT /translation="MTPADLAELLKTTAIVVLAERGLDAAALPQTVTVERPRNPEHGDY FT SSNLAMQLGKKVGANPLELAGWLAEVLAQAGGIADVEVAGPGFINMRLDASAQAMIVNT FT VINADKNFGHSDDLAGYQINLEFVSANPTGPIHIGGTRWAAVGDALGRLLSTQGAAVVR FT EYYFNDHGAQIDRFTNSLIAAAKGELTPADGYAGTYVTDIAAQVMQQAPYALSLPESEM FT HETVREIGVDLMFTHIKKSLHEFGTDFDVYTHEDSMHASGRVDEAIARLRDTGNVYEKD FT GALWLRTSAFGDDKDRVVIKSDGKPAYIAGDLAYYLDKRQRGFDLCIYMLGADHHGYIA FT RLKAAAAAFGDDPAIVEVLIGQMVNLVCDGQLVRMSKRSGNVITLDDLVEAIGVDAARY FT SLIRSSVDTPIDIDLALWSSSSNENPVYYVQYAHARLSALARNAAEFGLIPDTGHLELL FT SHDKEGALLRTVGEFPQVLKTAAALREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEKP FT TDLHTARLALCQANRQVIANGLAILGVSAPERM" FT misc_feature 316580..318220 FT /note="Pfam match to entry PF00750 tRNA-synt_1d, tRNA FT synthetases class I (R), score 1082.30, E-value 0" FT misc_feature 316964..316993 FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT CDS 318220..319638 FT /transl_table=11 FT /gene="lysA" FT /gene_synonym="ML1128" FT /product="diaminopimelate decarboxylase" FT /note="Previously sequenced Mycobacterium leprae TR:Q50140 FT (EMBL:U15186) (495 aa); Fasta score E(): 0, 100.0% identity FT in 472 aa overlap. Highly similar to many diaminopimelate FT decarboxylases (EC 4.1.1.20) involved in the last step of FT lysine biosynthesis e.g. Mycobacterium tuberculosis, LysA, FT SW:DCDA_MYCTU (P31848) (447 aa); Fasta score E(): 0, 86.8% FT identity in 446 aa overlap. Contains Pfam match to entry FT PF00750 tRNA-synt_1d, tRNA synthetases class I (R). FT Contains Pfam match to entry PF00278 Orn_DAP_Arg_deC, FT Pyridoxal-dependent decarboxylase. Contains PS00878 FT Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment FT site." FT /db_xref="GOA:Q50140" FT /db_xref="HSSP:1HKV" FT /db_xref="InterPro:IPR000183" FT /db_xref="UniProtKB/Swiss-Prot:Q50140" FT /protein_id="CAC31509.1" FT /translation="MNVHTAGPRHAEKTRHTATPQRVQPSDDLLRLASNVWPRNITRDE FT TGVACIAGNKLTDLAGEYGTPLFVIDEDDFRFRCREIAAAFGGGENVHYAAKAFLCTEI FT ARWIDEEGLSLDVCSGGELAVALHASFPPERISLHGNNKSVAELKDAVKAGVGYIVLDS FT TTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFIATAHEDQKFGLSVASGAAMAAVR FT RVFATDNLRLVGLHSHIGSQIFDVAGFELAAHRVIGLLCDIVGEFDPEKTAQLSIVDLG FT GGLGISYLPDDDPPPIFELAAKLGAIVSNESAAVGLPVPKLMVEPGRAIAGPGTITLYE FT VGTIKDVDVSATAHRRYVSIDGGMSDNIRTALYDAQYDVRLVSRTSDAPAAPASIVGKH FT CESGDIVVRDTWVPDDLKPGDLVGVAATGAYCYSLSSRYNMLGRPAVVAVCAGQARLIL FT RRETVDDLLSLEVR" FT misc_feature 318418..319542 FT /note="Pfam match to entry PF00278 Orn_DAP_Arg_deC, FT Pyridoxal-dependent decarboxylase, score 337.70, E-value FT 3.8e-100" FT misc_feature 318499..318555 FT /note="PS00878 Orn/DAP/Arg decarboxylases family 2 FT pyridoxal-P attachment site" FT RBS 319632..319637 FT CDS 319642..320967 FT /transl_table=11 FT /gene="hom" FT /gene_synonym="ML1129" FT /product="homoserine dehydrogenase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae homoserine dehydrogenase (EC 1.1.1.3) SW:DHOM_MYCLE FT (P46806) (441 aa); Fasta score E(): 0, 99.8% identity in FT 441 aa overlap. Also highly similar to orthologues from FT Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa); FT Fasta score E(): 0, 89.5% identity in 438 aa overlap and FT Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa); FT Fasta score E(): 0, 60.3% identity in 431 aa overlap. FT Contains Pfam match to entry PF00742 Homoserine_dh, FT Homoserine dehydrogenase. Contains Pfam match to entry FT PF01842 ACT, ACT domain. Contains PS01042 Homoserine FT dehydrogenase signature." FT /db_xref="GOA:P46806" FT /db_xref="InterPro:IPR019811" FT /db_xref="UniProtKB/Swiss-Prot:P46806" FT /protein_id="CAC31510.1" FT /translation="MFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRG FT IGVRRVAVDRGVPVDLLTDNIEELVSRADVDIVVEVMGPVELSRKAILSALEHGKSVVT FT ANKALLAASTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGT FT TNYILSAMDSTGADYDSALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTA FT DDVYREGITKITPADFVSARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPL FT ATVSGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPKESKY FT AQLPMETIGFISTRYYVSMNVADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVG FT ARIVVVTHGATDAALSETVDALADLDVVQGVTSVLRLEGISL" FT misc_feature 319696..320619 FT /note="Pfam match to entry PF00742 Homoserine_dh, FT Homoserine dehydrogenase, score 554.10, E-value 9e-163" FT misc_feature 320194..320262 FT /note="PS01042 Homoserine dehydrogenase signature" FT misc_feature 320704..320940 FT /note="Pfam match to entry PF01842 ACT, ACT domain, score FT 47.40, E-value 3.2e-10" FT CDS 320964..322046 FT /transl_table=11 FT /gene="thrC" FT /gene_synonym="ML1130" FT /product="threonine synthase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae probable threonine synthase (EC 4.2.99.2) FT SW:THRC_MYCLE (P45837;) (360 aa); Fasta score E(): 0, 99.7% FT identity in 360 aa overlap. Also highly similar to many FT other threonine synthases e.g. Mycobacterium tuberculosis FT SW:THRC_MYCTU (Q10610) (360 aa); Fasta score E(): 0, 94.9% FT identity in 354 aa overlap and Brevibacterium FT lactofermentum SW:THRC_BRELA (P09123) (352 aa); Fasta score FT E(): 0, 57.9% identity in 337 aa overlap. Contains Pfam FT match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate FT dependent enzyme. Contains PS00165 Serine/threonine FT dehydratases pyridoxal-phosphate attachment site." FT /db_xref="GOA:P45837" FT /db_xref="HSSP:1E5X" FT /db_xref="InterPro:IPR004450" FT /db_xref="UniProtKB/Swiss-Prot:P45837" FT /protein_id="CAC31511.1" FT /translation="MSGQQTTTHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAAP FT RLSEQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALARGQRAVLCASTGNTSASAAAYA FT ARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPMISLVN FT SVNPVRIEGQKTAVFEIVDALGTAPHVHALPVGNAGNITAYWKGYTEYHADGLIDRLPR FT MLGTQAAGAAPLVLGEPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAATDEEIL FT AAYHLVARAEGVFVEPASAASIAGLLKAIDGGWVARGSTVVCTITGNGLKDPDTALKDM FT PSVSPVPVDAVAVVEQLGLV" FT misc_feature 321057..321947 FT /note="Pfam match to entry PF00291 S_T_dehydratase, FT Pyridoxal-phosphate dependent enzyme, score 330.20, E-value FT 2.3e-95" FT misc_feature 321141..321182 FT /note="PS00165 Serine/threonine dehydratases FT pyridoxal-phosphate attachment site" FT CDS 322114..323061 FT /transl_table=11 FT /gene="thrB" FT /gene_synonym="ML1131" FT /product="homoserine kinase" FT /note="Identical to the previously sequenced Mycobacterium FT leprae homoserine kinase (EC 2.7.1.39) SW:KHSE_MYCLE FT (P45836) (314 aa); Fasta score E(): 0, 99.7% identity in FT 314 aa overlap. Also highly similar to many other FT homoserine kinases including: Mycobacterium tuberculosis FT SW:KHSE_MYCTU (Q10603) (316 aa); Fasta score E(): 0, 82.0% FT identity in 311 aa overlap and Corynebacterium glutamicum FT SW:KHSE_CORGL (P08210) (308 aa); Fasta score E(): 0, 48.7% FT identity in 312 aa overlap. Contains Pfam match to entry FT PF00288 GHMP_kinases, GHMP kinases putative ATP-binding FT proteins. Contains PS00627 GHMP kinases putative FT ATP-binding domain." FT /db_xref="GOA:P45836" FT /db_xref="InterPro:IPR014721" FT /db_xref="UniProtKB/Swiss-Prot:P45836" FT /protein_id="CAC31512.1" FT /translation="MVTWMLPAGLVASAVVAASSANLGPGFDSIGLALSLCDEIVVETT FT DSGLVVVVDGEGADQVPMGPEHLVVRAVRRGLQAVGVSAAGLVVRCRNAIPHSRGLGSS FT AAAVVGGLAVVNGFVAQIDSTPLSNAQLIQLASEFEGHPDNAAAAVLGGAVVSWVDRSY FT DQPDYCAVPLRLHPDIHLFAAIPEERSSTAESRVLLPARVSHDDARFNVSRAALLVVAL FT TERPDLLMAATEDVLHQPHRASAMSASAEYLRLLRRHNVAATLSGAGPSLIALSTQSEL FT PREAAEYGAANGFIIIKMTAGDEVCWRPEVTVPG" FT misc_feature 322333..322536 FT /note="Pfam match to entry PF00288 GHMP_kinases, GHMP FT kinases putative ATP-binding proteins, score 76.30, E-value FT 3.8e-20" FT misc_feature 322396..322431 FT /note="PS00627 GHMP kinases putative ATP-binding domain" FT CDS 323331..325163 FT /transl_table=11 FT /gene="rho" FT /gene_synonym="ML1132" FT /product="transcription termination factor Rho" FT /note="Identical to the previously sequenced Mycobacterium FT leprae transcription termination factor Rho SW:RHO_MYCLE FT (P45835) (610 aa); Fasta score E(): 0, 99.8% identity in FT 610 aa overlap. Also highly similar to many other FT transcriptional terminators ihncluding: Mycobacterium FT tuberculosis SW:RHO_MYCTU (Q10607) (602 aa); Fasta score FT E(): 0, 81.5% identity in 616 aa overlap and Micrococcus FT luteus SW:RHO_MICLU (P52154) (690 aa); Fasta score E(): 0, FT 66.0% identity in 467 aa overlap. Contains Pfam match to FT entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family." FT /db_xref="GOA:P45835" FT /db_xref="HSSP:1PV4" FT /db_xref="InterPro:IPR004665" FT /db_xref="UniProtKB/Swiss-Prot:P45835" FT /protein_id="CAC31513.1" FT /translation="MTETDLITVGENTDDTELTNAVTTDTPDVKATAATVSLGSLSTMV FT LPELRALANQAGVKGTSGMRKSELIAAIEECRGQANGTSVNDGPSRDHGGSATAISTEA FT LAAQEEQNYAIVEVSRRERRGASREADVTAGTSTAEATESDCQGTADDDTRTLQGGQSD FT TKTEERGPDVGNDQGVEQQSSSLQPRGDDDGEGRQGRRGRRFRDRDRRRRGERSGDGAE FT AELRQDDVVQPVAGILDVLDNYAFVRTSGYLAGPHDVYVSMSMVRKNGLRRGDAVTGAV FT RVPREGEQGHQRQKFNPLVRLDSINGGSVEDAKKRPEFGKLTPLYPNQRLRLETTPDRL FT TTRVIDLIMPIGKGQRALIVSPPKAGKTTILQDIANAITRNNLECHLMVVLVDERPEEV FT TDMQRSVKGEVIASTFDRPPSDHTSVAELAIERAKRLVEQGKDVVVLLDSITRLGRAYN FT NASPASGRILSGGVDSTALYPPKRFLGAARNIEEGGSLTIIATAMVETGSTGDMVIFEE FT FKGTGNAELKLDRKIAERRVFPAVDVNPSGTRKDELLLSPDEFGIVHKLRRVLSGLDSH FT QAIDLLMSQLRKTKTNYEFLVQVSKTTPGSMDDD" FT misc_feature 324030..324977 FT /note="Pfam match to entry PF00006 ATP-synt_ab, ATP FT synthase alpha/beta family, score -74.70, E-value 9.9e-06" FT misc_feature 325474..325677 FT /note="Pfam match to entry PF01197 Ribosomal_L31, Ribosomal FT protein L31, score 160.50, E-value 2.9e-44" FT CDS 325474..325728 FT /transl_table=11 FT /gene="rpmE" FT /gene_synonym="ML1133" FT /product="50S ribosomal protein L31" FT /note="Identical to the previously sequenced Mycobacterium FT leprae 50s ribosomal protein L31 SW:RL31_MYCLE (P45834) (84 FT aa); Fasta score E(): 0, 100.0% identity in 84 aa overlap, FT as well as being highly similar to many others e.g. FT Mycobacterium tuberculosis SW:RL31_MYCTU (Q10608) (80 aa); FT Fasta score E(): 5.8e-27, 89.6% identity in 77 aa overlap FT and Escherichia coli SW:RL31_ECOLI (P02432) (70 aa); Fasta FT score E(): 3.4e-11, 53.8% identity in 65 aa overlap. FT Contains Pfam match to entry PF01197 Ribosomal_L31, FT Ribosomal protein L31. Contains PS00190 Cytochrome c family FT heme-binding site signature. Contains PS01143 Ribosomal FT protein L31 signature." FT /db_xref="GOA:P45834" FT /db_xref="InterPro:IPR002150" FT /db_xref="UniProtKB/Swiss-Prot:P45834" FT /protein_id="CAC31514.1" FT /translation="MKANIHPAYAETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPFY FT TGKQKILDSGGRVARFEKRYGKRKVGVDQVAAYPEQNNK" FT misc_feature 325585..325602 FT /note="PS00190 Cytochrome c family heme-binding site FT signature" FT misc_feature 325597..325653 FT /note="PS01143 Ribosomal protein L31 signature" FT RBS 325809..325813 FT CDS 325819..326904 FT /transl_table=11 FT /gene="prfA" FT /gene_synonym="ML1134" FT /product="peptide chain release factor 1" FT /note="Identical to the previously sequenced Mycobacterium FT leprae peptide chain release factor 1 (RF-1), directing the FT termination of translation, SW:RF1_MYCLE (P45833) (357 aa); FT Fasta score E(): 0, 99.7% identity in 357 aa overlap. Also FT highly similar to many other Prokaryotic and Eukaryotic FT chain release factors e.g. from Mycobacterium tuberculosis FT SW:RF1_MYCTU (Q10605) (357 aa); Fasta score E(): 0, 89.4% FT identity in 360 aa overlap and Kluyveromyces lactis (Yeast) FT SW:RF1M_KLULA (P41767) (396 aa); Fasta score E(): 0, 39.9% FT identity in 368 aa overlap. Contains Pfam match to entry FT PF00472 RF-1, Peptidyl-tRNA hydrolase domain. Contains FT PS00745 Prokaryotic-type class I peptide chain release FT factors signature." FT /note="ML0667" FT /db_xref="GOA:P45833" FT /db_xref="HSSP:1GQE" FT /db_xref="InterPro:IPR004373" FT /db_xref="UniProtKB/Swiss-Prot:P45833" FT /protein_id="CAC31515.1" FT /translation="MAQPVQSIDVLLIEHAELELALADPELHSNPAEARKAGRRFARLA FT PIVATHRKLISARDDLQTARELAAGDESFADEIAELESRIAELTTQLTDMLAPHDPHGP FT DDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWTVTVLDETTSDLGGYKDATLAIS FT HKGASDGDAVDGVWSRMKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEIGEVHI FT DESDLRIDVYRSSGKGGQGVNTTDSAVRITHLPTGVVVTCQNERSQLQNKTRALQVLAA FT RLQAMAEEQALANASADRASQIRTVDRSERIRTYNFPENRITDHRIGYKAHNLDQVLDG FT DLDALFDALSAADKQSRLQQV" FT misc_feature 326455..326796 FT /note="Pfam match to entry PF00472 RF-1, Peptidyl-tRNA FT hydrolase domain, score 238.90, E-value 7.4e-68" FT misc_feature 326515..326565 FT /note="PS00745 Prokaryotic-type class I peptide chain FT release factors signature" FT CDS 326901..327767 FT /transl_table=11 FT /gene="ML1135" FT /product="possible protoporphyrinogen oxidase" FT /note="Highly similar to numerous members of the HemK FT family of modification methylases such as Mycobacterium FT tuberculosis, Rv1300, SW:HEMK_MYCTU (Q10602) (325 aa); FT Fasta score E(): 0, 73.9% identity in 284 aa overlap and FT Escherichia coli SW:HEMK_ECOLI (P37186) (277 aa); Fasta FT score E(): 2.4e-17, 32.5% identity in 277 aa overlap." FT /db_xref="GOA:P45832" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:P45832" FT /protein_id="CAC31516.1" FT /translation="MMIRLRRAIDSAVTQLEEAGIGSARCDAEQLAAHLAGTDRGRLAL FT LDTPGEEFFRRYSDAVAARSRRVPLQHLIGTVSFGPVVLHVGPDVFIPRPETEAILAWV FT MAQRLPERPVIVDACTGSGALAVALAHHRPAARVIGIDDSDSALDYARRNAEGTAVECV FT RADVTTPALLPELDGCVDLFVANPPYVPDDPVVQSILEPEVTQYDPRHAVFGGPDGMAL FT TADIVGLAGRWLRPGGLFAVEHDDSTSVPTLDLVYRTDLFDDVLTHRDLAGRPRFVTAR FT RRESWSA" FT RBS 327800..327804 FT CDS 327807..328469 FT /transl_table=11 FT /gene="ML1136" FT /product="conserved hypothetical protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae hypothetical protein SW:YD01_MYCLE (P45831) (220 FT aa); Fasta score E(): 0, 99.5% identity in 220 aa overlap. FT Also highly similar to several other proteins of undefined FT function e.g. Mycobacterium tuberculosis Rv1301 FT SW:YD01_MYCTU (Q10618) (217 aa); Fasta score E(): 0, 83.3% FT identity in 215 aa overlap. Contains Pfam match to entry FT PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family. Contains FT PS01147 SUA5/yciO/yrdC family signature." FT /db_xref="InterPro:IPR006070" FT /db_xref="UniProtKB/Swiss-Prot:P45831" FT /protein_id="CAC31517.1" FT /translation="MVRMNEVFDCADPDQRARGIASAVAALKGGRLVVMPTDTVYGIGA FT DAFDRAAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYTMPDGARELIRAFWPGALSLV FT VVHAPSLNWDLGDAHGTVMLRMPLHSVAIELLCEVGPMAVSSANVSGQPAAVDVDGARG FT QLGELVGVYLDAGPSAQQAASTIVDLTEATPRILRAGPVSVARIAEVLGVVPASLIA" FT misc_feature 327876..328406 FT /note="Pfam match to entry PF01300 Sua5_yciO_yrdC, FT SUA5/yciO/yrdC family, score 268.20, E-value 1.1e-76" FT misc_feature 327900..327938 FT /note="PS01147 SUA5/yciO/yrdC family signature" FT CDS 328500..329699 FT /transl_table=11 FT /gene="ML1137" FT /product="possible glycosyltransferase" FT /note="Previously sequenced Mycobacterium leprae FT SW:RFE_MYCLE (P45830) (398 aa); Fasta score E(): 0, 99.7% FT identity in 398 aa overlap. Similar to many including: FT Mycobacterium tuberculosis putative undecaprenyl-phosphate FT alpha-N-acetylglucosaminyltransferase SW:RFE_MYCTU (Q10606) FT (404 aa); Fasta score E(): 0, 89.2% identity in 398 aa FT overlap and Bacillus subtilis FT phospho-N-acetylmuramoyl-pentapeptide-transferase FT SW:MRAY_BACSU (Q03521) (324 aa); Fasta score E(): 1.9e-07, FT 28.6% identity in 297 aa overlap. Contains multiple FT possible membrane spanning hydrophobic domains. Contains FT Pfam match to entry PF00953 Glycos_transf_4, Glycosyl FT transferase." FT /db_xref="GOA:P45830" FT /db_xref="InterPro:IPR018481" FT /db_xref="UniProtKB/Swiss-Prot:P45830" FT /protein_id="CAC31518.1" FT /translation="MVQYVREMSSDLATFASGLLALFERSAGVPLRELALVGLTAAIIT FT YFATGLVGVLANRLEAVAYPRERDVHVTPTPRMGGLAMYLGVLAAVFLASQLPALTRGF FT VYSSGMPAVLVAGAVITGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPLG FT GVGTIVLDQTSSILLTLALTVSIVNAINFVDGLDGLAAGLGLITAMAICIFSVGLLRDH FT DGDVLFYPPAVISVVLAGSCLGFLPHNFHRAKIFMGDSGSMLVGLMLAAASTTAAGPIS FT QNAYGTRDVFALLSPFLLVVAVMFVPMLDLLLAIVRRIRAGRSAFSPDKMHLHHRLLQI FT GHSHRRVVLLIYLWVGIVAFGAASTIFFNPRNTGAVMLGAIVITGMATVIPLLRRRDNY FT " FT misc_feature 328827..329345 FT /note="Pfam match to entry PF00953 Glycos_transf_4, FT Glycosyl transferase, score 211.60, E-value 1.2e-59" FT RBS 329951..329955 FT CDS 329962..330423 FT /transl_table=11 FT /gene="ML1138" FT /product="possible integral membrane protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae SW:YD03_MYCLE (P53431) (153 aa); Fasta score E(): 0, FT 99.3% identity in 153 aa overlap. Also highly similar to FT Mycobacterium tuberculosis hypothetical protein Rv1303 FT SW:YD03_MYCTU (Q10619) (161 aa); Fasta score E(): 0, 69.8% FT identity in 149 aa overlap. Contains possible membrane FT spanning hydrophobic domains." FT /db_xref="GOA:P53431" FT /db_xref="InterPro:IPR008413" FT /db_xref="UniProtKB/Swiss-Prot:P53431" FT /protein_id="CAC31519.1" FT /translation="MTTPAQDAPLVLPAVAFRPVRLFIINIVLTGLAMLAAGLSGHLMV FT GVFFGIGLLLGLLNALLVRCSVESITAQGHPLKRSMALNSASRLAIITVFGLIIAYAFP FT LAGLGVVFGLALFQVLLVLSTMLPVWRKFRFGEADGGVLKGSEGEEQQR" FT CDS 330420..331175 FT /transl_table=11 FT /gene="atpB" FT /gene_synonym="ML1139" FT /product="probable ATP synthase A chain protein" FT /note="Identical to the previously sequenced Mycobacterium FT leprae ATP synthase A chain (EC 3.6.1.34) SW:ATP6_MYCLE FT (P45829) (251 aa); Fasta score E(): 0, 100.0% identity in FT 251 aa overlap. Also highly similar to many other FT Prokaryotic and Eukaryotic proposed ATPase A chain family FT proteins e.g. Mycobacterium tuberculosis Rv1304 FT SW:ATP6_MYCTU (Q10591) (250 aa); Fasta score E(): 0, 84.0% FT identity in 250 aa overlap and Nicotiana tabacum (Common FT tobacco) SW:ATPI_TOBAC (P06288) (247 aa); Fasta score E(): FT 3.3e-18, 32.5% identity in 246 aa overlap. Contains FT possible membrane spanning hydrophobic domains. Contains FT Pfam match to entry PF00119 ATP-synt_A, ATP synthase A FT chain. Contains PS00449 ATP synthase a subunit signature." FT /db_xref="GOA:P45829" FT /db_xref="HSSP:1C17" FT /db_xref="InterPro:IPR000568" FT /db_xref="UniProtKB/Swiss-Prot:P45829" FT /protein_id="CAC31520.1" FT /translation="MTETILSGGQIEVGEHHTTTWFGMTVNTDTVLSTAIAAAIVIALA FT FFLRTKVNSTGVPCGMQLFWEAITVQMRTQIESAIGMRIAPFVLPLAVTIFVFILISNW FT LSVLPLQYTNADGHTTEVLSSAAADINYVLALAFFVFVCYHLAGIWRRGIVGHPVAVLK FT GHVAFLAPINLVEEITKPISLSLRLFGNIFAGGILVTLIALFPPYIMWAPNAIWKSFDL FT FVGAIQAFIFSILTILYFSQAMEVEDHHD" FT misc_feature 330672..331145 FT /note="Pfam match to entry PF00119 ATP-synt_A, ATP synthase FT A chain, score 210.10, E-value 3.4e-59" FT misc_feature 330966..330995 FT /note="PS00449 ATP synthase a subunit signature" FT RBS 331259..331263 FT CDS 331271..331516 FT /transl_table=11 FT /gene="atpE" FT /gene_synonym="ML1140" FT /product="probable ATP synthase C chain" FT /note="Identical to the previously sequenced Mycobacterium FT leprae ATP synthase C chain protein (EC 3.6.1.34) FT SW:ATPL_MYCLE (P45828) (81 aa); Fasta score E(): 1.1e-25, FT 100.0% identity in 81 aa overlap. Also highly similar to FT many other Prokaryotic and Eukaryotic proposed ATPase C FT chain family proteins e.g. Mycobacterium tuberculosis FT Rv1305 SW:ATPL_MYCTU (Q10598) (81 aa); Fasta score E(): FT 6.4e-24, 92.6% identity in 81 aa overlap and Euglena FT gracilis SW:ATPH_EUGGR (P10603) (81 aa); Fasta score E(): FT 4.8e-06, 36.7% identity in 79 aa overlap. Contains possible FT membrane spanning hydrophobic domains. Contains Pfam match FT to entry PF00137 ATP-synt_C, ATP synthase subunit C. FT Contains PS00605 ATP synthase c subunit signature." FT /db_xref="GOA:P45828" FT /db_xref="InterPro:IPR002379" FT /db_xref="UniProtKB/Swiss-Prot:P45828" FT /protein_id="CAC31521.1" FT /translation="MDPMIAQGALIGGGLIMAGGAIGAGIGDGMAGNALVSGIARQPEA FT QSRLFTPFFITVGLVEAAYFINLAFMALFVFATPVK" FT misc_feature 331292..331501 FT /note="Pfam match to entry PF00137 ATP-synt_C, ATP synthase FT subunit C, score 93.30, E-value 4.7e-24" FT misc_feature 331388..331453 FT /note="PS00605 ATP synthase c subunit signature" FT CDS 331538..332050 FT /transl_table=11 FT /gene="atpF" FT /gene_synonym="ML1141" FT /product="probable ATP synthase B chain" FT /note="Identical to the previously sequenced Mycobacterium FT leprae ATP synthase B chain (EC 3.6.1.34) SW:ATPF_MYCLE FT (P45827) (170 aa); Fasta score E(): 0, 100.0% identity in FT 170 aa overlap. Also highly similar to many other proposed FT ATPase B chain family proteins e.g. Mycobacterium FT tuberculosis Rv1306 SW:ATPF_MYCTU (Q10596) (171 aa); Fasta FT score E(): 0, 79.5% identity in 171 aa overlap and Bacillus FT PS3 (Thermophilic bacterium PS-3) SW:ATPF_BACP3 (P09221) FT (163 aa); Fasta score E(): 0.00044, 22.5% identity in 142 FT aa overlap. Contains possible membrane spanning hydrophobic FT domains. Contains Pfam match to entry PF00430 ATP-synt_B, FT ATP synthase B/B' CF(0)." FT /db_xref="GOA:P45827" FT /db_xref="InterPro:IPR002146" FT /db_xref="UniProtKB/Swiss-Prot:P45827" FT /protein_id="CAC31522.1" FT /translation="MFEVSAIVFAVSQAAEEGKSSNFLLPNGTFFFVLAIFLVVLGVIG FT TFVVPPILKVLQERDAMVAKTDADSKMSAAQFAAAQADYEAAMKEARVQSSFLRDNARV FT DGRKSIEEARVRAEQHVVSTLQIAGEQIKRERDAVELDLRAKAGAMSLILASRILGVDI FT TASVVTR" FT misc_feature 331622..332032 FT /note="Pfam match to entry PF00430 ATP-synt_B, ATP synthase FT B/B' CF(0), score 137.60, E-value 4.5e-38" FT CDS 332056..333396 FT /transl_table=11 FT /gene="atpH" FT /gene_synonym="ML1142" FT /product="bi-domained ATP synthase B, [Delta] chain FT protein" FT /note="Previously sequenced Mycobacterium leprae FT SW:ATPD_MYCLE (P53006) (446 aa); Fasta score E(): 0, 100.0% FT identity in 446 aa overlap. The N-terminus of this protein FT shares high sequence identity with many ATP synthase B FT chain proteins e.g. Haemophilus influenzae SW:ATPF_HAEIN FT (P43720) (156 aa); Fasta score E(): 4.8e-05, 24.8% identity FT in 153 aa overlap and the C-terminus shares high homology FT with many ATP synthase [delta] chain proteins e.g. FT Streptomyces lividans SW:ATPD_STRLI (P50008) (272 aa); FT Fasta score E(): 3.4e-20, 33.1% identity in 266 aa FT overlap_ATP. Also highly similar over the entire range to FT Mycobacterium tuberculosis Rv1307 SW:ATPD_MYCTU (Q10594) FT (446 aa); Fasta score E(): 0, 77.8% identity in 446 aa FT overlap. Contains possible coiled-coils and a possible FT N-terminal signal sequence. Contains Pfam match to entry FT PF00213 OSCP, ATP synthase delta (OSCP) subunit. Contains FT Pfam match to entry PF00430 ATP-synt_B, ATP synthase B/B' FT CF(0). Contains PS01094 Uncharacterized protein family FT UPF0076 signature." FT /db_xref="GOA:P53006" FT /db_xref="InterPro:IPR002146" FT /db_xref="UniProtKB/Swiss-Prot:P53006" FT /protein_id=" |