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EBI DbfetchID AL583919; SV 1; linear; genomic DNA; STD; PRO; 312050 BP. XX AC AL583919; XX DT 20-FEB-2001 (Rel. 66, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 3) XX DE Mycobacterium leprae strain TN complete genome; segment 3/10 XX KW . XX OS Mycobacterium leprae OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium. XX RN [1] RP 1-312050 RX DOI; 10.1038/35059006 RX PUBMED; 11234002. RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., RA Wheeler P.R., Honore N., Ganier T., Churcher C., Harris D., Mungall K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., RA Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., RA Jagels K., Lacroix C., Maclean J., Moule S., Murphy L., Oliver, Quail M.A., RA Rajandream M-A., Rutherford K.M., Rutter S., Seeger K., Simon S., RA Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., RA Whitehead S., Woodward J.R., Barrell B.G.; RT "Massive gene decay in the leprosy bacillus"; RL Nature 409(6823):1007-1011(2001). XX RN [2] RP 1-312050 RA Parkhill J.; RT ; RL Submitted (20-FEB-2001) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium leprae sequencing teams, The RL Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, RL UK Unitie de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du RL Docteur Rouux, 75724, Paris Cedex, France. E-mail: parkhill@sanger.ac.uk XX DR EMBL-CON; AL450380. DR GOA; Q49744. DR RFAM; RF00634; SAM-IV. DR UniProtKB/Swiss-Prot; Q49744; RNZ_MYCLE. XX CC Notes: CC CC Details of M. leprae sequencing at the Sanger Centre CC are available from http://www.sanger.ac.uk/Projects/M_leprae/ CC A relational datbase containing the M. leprae sequences is available from CC http://genolist.pasteur.fr/Leproma/ XX FH Key Location/Qualifiers FH FT source 1..312050 FT /organism="Mycobacterium leprae" FT /strain="TN" FT /mol_type="genomic DNA" FT /db_xref="taxon:1769" FT repeat_region complement(2412..3665) FT /note="LEPRPT, copy 1, 1254 bp. Shows 99-100% identity with FT regions 727207..728460, 1539937..1541188, 1480312..1481018, FT 2203983..2204515, 691673..691731" FT repeat_region complement(2413..2473) FT /note="61 bp repeat found at 3'-end of LEPRPT and 5' to FT REPLEP" FT CDS complement(5611..6426) FT /transl_table=11 FT /gene="ML0569" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv1433, putative membrane FT protein, TR:O06825 (EMBL:AL123456) (271 aa); Fasta score FT E(): 0, 68.3% identity in 271 aa overlap. Shows weak FT similarity to other hypothetical proteins in M. FT tuberculosis. Previously sequenced as TR:Q49706 FT (EMBL:U00013) (271 aa); Fasta score E(): 0, 100.0% identity FT in 271 aa overlap." FT /note="Similar to ML0426, ML2446 and ML2664" FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:Q49706" FT /protein_id="CAC30077.1" FT /translation="MGIMRAAIRGVLVVIGIAATVIAGPVRVSLAAVNHAHGFAITSIL FT PTRDAVVGVAHPVVVTFGAPVTNRKATELSLKVRSAPAMNGKFDWLDSKVVQWVPDRYW FT PEHSTIALTVGNLSTNFKTGPAILGIADISNHTFTVTIDGVEAETPPPLPSPHHRPHWG FT EEGVMPASMGKTEFPTPTGKYTVMSKDRSVIMDSSSVGIPVDDPEGYRLSVDYAVRISS FT RGLYIHSAPWAVQSMGFDNTSHGCISLSPADAEWYYNTVNIGDPVIVKE" FT RBS 6876..6882 FT /note="possible RBS" FT CDS 6889..7908 FT /transl_table=11 FT /gene="gap" FT /gene_synonym="ML0570" FT /product="glyceraldehyde 3-phosphate dehydrogenase" FT /EC_number="1.2.1.12" FT /note="Similar to M. tuberculosis gap, Rv1436, FT glyceraldehyde 3-phosphate dehydrogenase, SW:G3P_MYCTU FT (O06822) (339 aa); Fasta score E(): 0, 89.1% identity in FT 339 aa overlap. Similar to many e.g. Mycobacterium avium FT gap, glyceraldehyde 3-phosphate dehydrogenase, SW:G3P_MYCAV FT (P94915) (339 aa); Fasta score E(): 0, 87.9% identity in FT 339 aa overlap. Previously sequenced as SW:G3P_MYCLE FT (P46713) (339 aa); Fasta score E(): 0, 99.7% identity in FT 339 aa overlap. Contains Pfam match to entry PF00044 gpdh, FT glyceraldehyde 3-phosphate dehydrogenases. Contains PS00071 FT Glyceraldehyde 3-phosphate dehydrogenase active site." FT /db_xref="GOA:P46713" FT /db_xref="HSSP:1GD1" FT /db_xref="InterPro:IPR006424" FT /db_xref="UniProtKB/Swiss-Prot:P46713" FT /protein_id="CAC30078.1" FT /translation="MTVRVGINGFGRIGRNFYRALLAQQEHGIADVQVVAINDITDNST FT LAYLLKFDSILGRLPHDVSLEEEDTIVVGSEKIKALAVREGPAALPWHAFGVDVVVEST FT GLFTNAAKAKGHLEAGAKKVIVSAPATDPDITIVFGVNDDKYDGSQNIISNASCTTNCL FT APLAKVLHDQFGIVKGLMTTVHAYTQDQNLQDGPHSDLRRARAAALNVVPTSTGAAKAI FT GLVMPELKGKLDGYALRVPIPTGSVTDLTADLSKCVSVNEINAVFQDAAEGRLKGILKY FT VDAPIVSSDIVTDPHSSIFDSGLTKVIASQAKVVSWYDNEWGYSNRLVDLVGLVGKSL" FT misc_feature 6892..7902 FT /note="Pfam match to entry PF00044 gpdh, glyceraldehyde FT 3-phosphate dehydrogenases, score 733.80, E-value 7.9e-219" FT misc_feature 7354..7377 FT /note="PS00071 Glyceraldehyde 3-phosphate dehydrogenase FT active site" FT misc_feature 7911..9140 FT /note="Pfam match to entry PF00162 PGK, Phosphoglycerate FT kinases, score 757.00, E-value 7.9e-224" FT CDS 7911..9161 FT /transl_table=11 FT /gene="pgk" FT /gene_synonym="ML0571" FT /product="phosphoglycerate kinase" FT /EC_number="2.7.2.3" FT /note="Similar to M. tuberculosis pgk, Rv1437, FT phosphoglycerate kinase, SW:PGK_MYCTU (O06821) (412 aa); FT Fasta score E(): 0, 80.6% identity in 412 aa overlap. FT Similar to many e.g. Corynebacterium glutamicum pgk, FT phosphoglycerate kinase, SW:PGK_CORGL (Q01655) (403 aa); FT Fasta score E(): 0, 59.2% identity in 407 aa overlap. FT Previously sequenced as SW:PGK_MYCLE (P46712) (416 aa); FT Fasta score E(): 0, 99.8% identity in 416 aa overlap. FT Contains Pfam match to entry PF00162 PGK, Phosphoglycerate FT kinases. Contains PS00111 Phosphoglycerate kinase FT signature." FT /db_xref="GOA:P46712" FT /db_xref="HSSP:1VPE" FT /db_xref="InterPro:IPR015824" FT /db_xref="UniProtKB/Swiss-Prot:P46712" FT /protein_id="CAC30079.1" FT /translation="MRIPNLKDLLEEGVSGRCVLVRCDLNVPLGDDGAITDLGRVTASV FT PTLKALLEAGAKIVVAAHLGRPKNGPDPKLSLEPVAAALGEQLGQNVQLVCSTDRSPVG FT GDALACVERLTDGDLLLLQNIRFDPRETSKVDDERLALAKQLVELVGSAGAFVSDGFGV FT VHRRQASVYDVATLLPHYAGILVADEIRILEQLTSSAKRPYAVVLGGSKVSDKLGVIES FT LATKADSIVLGGGMCFTFLAAQGFSVGKSLLETEMIETCRSLLDTYADVLRLPMDIVVT FT EKFVADSPPQTVAADAIPDGLMGLDIGPESVKRFATLLSNASTIFWNGPMGVFEFPAYA FT AGTRGVAEAIVAVTGKGAFSVVGGGDSAAAMRALSLPEGSVSHLSTGGGASLEYLEGKT FT LPGIEVLGREQPRGGDS" FT misc_feature 7962..7994 FT /note="PS00111 Phosphoglycerate kinase signature" FT RBS 9149..9153 FT /note="possible RBS" FT CDS 9158..9943 FT /transl_table=11 FT /gene="tpi" FT /gene_synonym="ML0572" FT /product="triosephosphate isomerase" FT /EC_number="5.3.1.1" FT /note="Similar to M. tuberculosis tpi, Rv1438, FT triosephosphate isomerase, SW:TPIS_MYCTU (O08408) (261 aa); FT Fasta score E(): 0, 83.9% identity in 261 aa overlap. FT Similar to many e.g. Corynebacterium glutamicum tpi, FT triosephosphate isomerase, SW:TPIS_CORGL (P19583) (259 aa); FT Fasta score E(): 0, 64.5% identity in 256 aa overlap. FT Previously sequenced as SW:TPIS_MYCLE (P46711) (261 aa); FT Fasta score E(): 0, 99.6% identity in 261 aa overlap. FT Contains Pfam match to entry PF00121 TIM, Triosephosphate FT isomerase. Contains PS00171 Triosephosphate isomerase FT active site." FT /db_xref="GOA:P46711" FT /db_xref="HSSP:2BTM" FT /db_xref="InterPro:IPR000652" FT /db_xref="UniProtKB/Swiss-Prot:P46711" FT /protein_id="CAC30080.1" FT /translation="MSRKSLIAGNWKMNLNHFEAIALVQKIAFSLPDKYYDKVDVTVLP FT PFTDLRSVQTLVDGDKLRLTYGAQDLSQHDLGAYTGDISGAFLAKLGCSFVLVGHSERR FT TYHDEGDALVAAKTAAALKNSLTPIVCIGEYLEIREVGEHVSHCQNQLRGSLAGLSPEQ FT IGNVVIVYEPVWAIGTGRVASAADAQEVCEAIRKELGALASPQVAETVRVLYGGSLNAK FT NIGDIVAQQDVDGGLVGGASLDGAQFATLAVIAAGGPLP" FT misc_feature 9164..9931 FT /note="Pfam match to entry PF00121 TIM, Triosephosphate FT isomerase, score 524.60, E-value 3.7e-169" FT misc_feature 9665..9697 FT /note="PS00171 Triosephosphate isomerase active site" FT CDS 9927..10202 FT /transl_table=11 FT /gene="ML0573" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:Q49684 FT (EMBL:U00013) (91 aa); Fasta score E(): 0, 98.9% identity FT in 91 aa overlap. Contains Pfam match to entry PF00121 TIM, FT Triosephosphate isomerase." FT /db_xref="UniProtKB/TrEMBL:Q49684" FT /protein_id="CAC30081.1" FT /translation="MGLFPREALGASCTDLVIGYAADFSRSVSSVLWVANSLWVQCACR FT VGVVATVALIAGIGVLSAIFQVVVLVFLGAFCGVSLVATGFYRDQW" FT CDS 10199..10516 FT /transl_table=11 FT /gene="ML0574" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:Q49680 FT (EMBL:U00013) (105 aa); Fasta score E(): 0, 99.0% identity FT in 105 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49680" FT /protein_id="CAC30082.1" FT /translation="MTLHIPRFARYSTMRSLRFASTATRFKRAWSVSVELAVVDAGRDS FT GLVELVDALSLEVGAPGDAVLATRRLSVLICAASFPYRPVQQRANQTFLAVATGIIMRD FT A" FT CDS 10674..10892 FT /transl_table=11 FT /gene="ML0575" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCN6" FT /protein_id="CAC30083.1" FT /translation="MVATVLALSFVVLSVPKLYGFGVIVITSAALLSQSICLAYPVAPA FT VCLVDMLISTVVVVCRIPVVAGRSVVA" FT CDS 11708..11938 FT /transl_table=11 FT /gene="ML0576" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:Q49681 FT (EMBL:U00013) (76 aa); Fasta score E(): 1.5e-31, 100.0% FT identity in 76 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49681" FT /protein_id="CAC30084.1" FT /translation="MASGVNILQDVFAVIVEVLLLSVGTGNARTAEDWPGLAVLSAGLV FT AVLTLLIHEQQEDWVCQPVTRLCWGRSTVDR" FT CDS 11950..12183 FT /transl_table=11 FT /gene="ML0577" FT /product="putative protein-export membrane protein" FT /note="Similar to M. tuberculosis secG, Rv1440, probable FT protein-export membrane protein, SW:SECG_MYCTU (O06819) (77 FT aa); Fasta score E(): 1.1e-25, 96.1% identity in 77 aa FT overlap. Similar to many e.g. Escherichia coli secG, FT protein-export membrane protein, SW:SECG_ECOLI (P33582) FT (110 aa); Fasta score E(): 0.06, 29.0% identity in 69 aa FT overlap. Previously sequenced as SW:SECG_MYCLE (P38388) (77 FT aa); Fasta score E(): 3.1e-26, 100.0% identity in 77 aa FT overlap. Contains hydrophobic, possible membrane-spanning FT regions." FT /db_xref="GOA:P38388" FT /db_xref="InterPro:IPR004692" FT /db_xref="UniProtKB/Swiss-Prot:P38388" FT /protein_id="CAC30085.1" FT /translation="MELALQITLVVTSILVVLLVLLHRAKGGGLSTLFGGGVQSSLSGS FT TVVEKNLDRLTLFVTGIWLVSIIGVALLTKYR" FT CDS 12214..15018 FT /transl_table=11 FT /gene="ppc" FT /gene_synonym="ML0578" FT /product="putative phosphoenolpyruvate carboxylase" FT /EC_number="4.1.1.31" FT /note="Similar to many e.g. Rhodopseudomonas palustris ppc, FT phosphoenolpyruvate carboxylase, SW:CAPP_RHOPA (O32483) FT (936 aa); Fasta score E(): 0, 45.7% identity in 936 aa FT overlap. Previously sequenced as SW:CAPP_MYCLE (P46710) FT (907 aa); Fasta score E(): 0, 100.0% identity in 907 aa FT overlap. Contains 2 Pfam matches to entry PF00311 PEPcase, FT Phosphoenolpyruvate carboxylase. Contains PS00781 FT Phosphoenolpyruvate carboxylase active site 1. Contains FT PS00393 Phosphoenolpyruvate carboxylase active site 2." FT /db_xref="GOA:P46710" FT /db_xref="HSSP:1JQN" FT /db_xref="InterPro:IPR015813" FT /db_xref="UniProtKB/Swiss-Prot:P46710" FT /protein_id="CAC30086.1" FT /translation="MVEFSDAILEPIGAVQRTRVGREATEPMRADIRLLGTILGDTLRE FT QNGDEVFDLVERVRVESFRVRRSEIDRADMARMFSGLDIHLAIPIIRAFSHFALLANVA FT EDIHRERRRHIHLDAGEPLRDSSLAATYAKLDLAKLDSATVADALTGAVVSPVITAHPT FT ETRRRTVFVTQRRITELMRLHAEGHTETADGRSIERELRRQILTLWQTALIRLARLQIS FT DEIDVGLRYYSAALFHVIPQVNSEVRNALRARWPDAELLSGPILQPGSWIGGDRDGNPN FT VTADVVRRATGSAAYTVVAHYLAELTHLEQELSMSARLITVTPELATLAASCQDAACAD FT EPYRRALRVIRGRLSSTAAHILDQQPPNQLGLGLPPYSTPAELCADLDTIEASLCTHGA FT ALLADDRLALLREGVGVFGFHLCGLDMRQNSDVHEEVVAELLAWAGMHQDYSSLPEDQR FT VKLLVAELGNRRPLVGDRAQLSDLARGELAVLAAAAHAVELYGSAAVPNYIISMCQSVS FT DVLEVAILLKETGLLDASGSQPYCPVGISPLFETIDDLHNGAAILHAMLELPLYRTLVA FT ARGNWQEVMLGYSDSNKDGGYLAANWAVYRAELALVDVARKTGIRLRLFHGRGGTVGRG FT GGPSYQAILAQPPGAVNGSLRLTEQGEVIAAKYAEPQIARRNLESLVAATLESTLLDVE FT GLGDAAESAYAILDEVAGLARRSYAELVNTPGFVDYFQASTPVSEIGSLNIGNRPTSRK FT PTTSIADLRAIPWVLAWSQSRVMLPGWYGTGSAFQQWVAAGPESESQRVEMLHDLYQRW FT PFFRSVLSNMAQVLAKSDLGLAARYAELVVDEALRRRVFDKIADEHRRTIAIHKLITGH FT DDLLADNPALARSVFNRFPYLEPLNHLQVELLRRYRSGHDDEMVQRGILLTMNGLASAL FT RNSG" FT misc_feature 12454..13158 FT /note="Pfam match to entry PF00311 PEPcase, FT Phosphoenolpyruvate carboxylase, score 49.50, E-value FT 1.2e-14" FT misc_feature 12682..12717 FT /note="PS00781 Phosphoenolpyruvate carboxylase active site FT 1" FT misc_feature 13390..14934 FT /note="Pfam match to entry PF00311 PEPcase, FT Phosphoenolpyruvate carboxylase, score 347.00, E-value FT 1.2e-103" FT misc_feature 13963..14001 FT /note="PS00393 Phosphoenolpyruvate carboxylase active site FT 2" FT CDS complement(15242..15985) FT /transl_table=11 FT /gene="pgl" FT /gene_synonym="ML0579" FT /product="putative 6-phosphogluconolactonase" FT /EC_number="3.1.1.31" FT /note="Similar to M. tuberculosis devB, Rv1445c, FT 6-phosphogluconolactonase, SW:6PGL_MYCTU (O06814) (247 aa); FT Fasta score E(): 0, 72.8% identity in 246 aa overlap. FT Similar to many e.g. C-terminal half of Homo sapiens FT gdh/6pgl endoplasmic bifunctional protein precursor FT (6-phosphogluconolactonase), SW:. Previously sequenced as FT SW:6PGL_MYCLE (Q49700) (247 aa); Fasta score E(): 0, 99.6% FT identity in 247 aa overlap. Contains Pfam match to entry FT PF01182 Glucosamine_iso, Glucosamine-6-phosphate FT isomerase." FT /db_xref="GOA:Q49700" FT /db_xref="InterPro:IPR006148" FT /db_xref="UniProtKB/Swiss-Prot:Q49700" FT /protein_id="CAC30087.1" FT /translation="MSASVEIFSDSKTMVGAAGKRLASTIQSAVAARERALIVLTGGSS FT GIGLLRDLATRGQQIDWSRVHLFWGDERYVPKDDDERNEKQARVALLDHIDIPPSQVHP FT MPAGDGEFGNDLEAAALAYEQLLAAYAAPGYPTPNFDVHLMGMGPEGHINSLFPNTVAV FT RETSRMVVGVRNSPKPPPERITLTLNAIQRSREVWLMVSGTAKADAVAAAMGGAPSASI FT PAAGAVGLETTLWLLDEEAAAKIPG" FT misc_feature complement(15269..15913) FT /note="Pfam match to entry PF01182 Glucosamine_iso, FT Glucosamine-6-phosphate isomerase, score 4.50, E-value FT 1.4e-06" FT CDS complement(16001..16798) FT /transl_table=11 FT /gene="ML0580" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1446c, hypothetical FT protein, TR:O06813 (EMBL:AL123456) (303 aa); Fasta score FT E(): 0, 70.3% identity in 239 aa overlap. Similar to FT hypothetical proteins from Streptomyces coelicolor e.g. FT SCC22.20, hypothetical protein, TR:Q9XAB8 (EMBL:AL096839) FT (351 aa); Fasta score E(): 7.1e-21, 36.0% identity in 203 FT aa overlap, although these have a short N-terminal FT extension relative to this homologue. Previously sequencd FT as TR:Q49699 (EMBL:U00013) (265 aa); Fasta score E(): 0, FT 100.0% identity in 265 aa overlap." FT /db_xref="InterPro:IPR019297" FT /db_xref="UniProtKB/TrEMBL:Q49699" FT /protein_id="CAC30088.1" FT /translation="MSRVLTLVITPYSKAMLKESIEAANGASHKYPNRIIIAMRVNSYA FT NKARLDAQLWVGADTGAGVVVSRTLAVYAHSVVISILLPDIPMVAWWPNIAPTMSGQDS FT LGKLAIQRITNATNSIDPLATIKSRLSDYTADDTHLAWDLITYWRALLTSAVNLPPHEP FT IDLALVSGMKTEPALDVLAGWLANRINRPLRRAVADLKVELIRNSETIVLSRPQTWVTS FT TLIRTVKPDALVPWGAQGSRGVPSRKSATTGSRQVLLQCLRRH" FT RBS complement(16813..16818) FT /note="possible RBS" FT CDS complement(16918..18434) FT /pseudo FT /transl_table=11 FT /gene="zwf2" FT /gene_synonym="ML0581" FT /product="glucose-6-phosphate 1-dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT zwf2 (Best blastx score 638)" FT CDS complement(18461..19588) FT /transl_table=11 FT /gene="tal" FT /gene_synonym="ML0582" FT /product="putative transaldolase" FT /EC_number="2.2.1.2" FT /note="Similar to M. tuberculosis tal, Rv1448c, FT transaldolase, SW:TAL_MYCTU (O06812) (373 aa); Fasta score FT E(): 0, 78.9% identity in 370 aa overlap. Similar to many FT e.g. Escherichia coli tal, transaldolase, SW:TALA_ECOLI FT (P78258) (316 aa); Fasta score E(): 7e-05, 29.6% identity FT in 270 aa overlap. Previously sequenced as SW:TAL_MYCLE FT (P55193) (375 aa); Fasta score E(): 0, 100.0% identity in FT 375 aa overlap. Contains Pfam match to entry PF00923 FT Transaldolase, Transaldolase. Contains PS01054 FT Transaldolase signature 1. Contains PS00958 Transaldolase FT active site." FT /db_xref="GOA:P55193" FT /db_xref="InterPro:IPR014634" FT /db_xref="UniProtKB/Swiss-Prot:P55193" FT /protein_id="CAC30090.1" FT /translation="MTSKIQNPNLAALSAAGVSVWLDDLSRDRLQSGNLQKLIDTKSVV FT GVTTNPSIFQKAFANGHAYDAQIAELAKRGANVDVTVRTVTTDDVRHACDVLACEWEAS FT HGKDGRVSIEVDPRLAHDTDKTIAQAVELWRIVDHPNLFIKIPATKAGLPAITAVLAEG FT ISVNVTLIFSVQRHREVIDAYLAGIEKAAEAGRDLSKIVSVASFFVSRVDTEIDKRLEK FT LGSEQALALRGQAGVANARLAYAAYQKAFEGGQRYQTLMARGAQVQRPLWASTGVKNPD FT YADTLYVTELVAPNTVNTMPETTIDAVADHGVIRGDTISGTTLSSQKVFDSLVAVGVDL FT IDVFAVLEHEGVQKFVKSWNELLKETQEQLDSVAK" FT misc_feature complement(18746..19522) FT /note="Pfam match to entry PF00923 Transaldolase, FT Transaldolase, score 413.80, E-value 1.6e-120" FT misc_feature complement(19112..19165) FT /note="PS00958 Transaldolase active site" FT misc_feature complement(19427..19453) FT /note="PS01054 Transaldolase signature 1" FT CDS complement(19605..21704) FT /transl_table=11 FT /gene="tkt" FT /gene_synonym="ML0583" FT /product="transketolase" FT /EC_number="2.2.1.1" FT /note="Similar to M. tuberculosis tkt, Rv1449c, FT transketolase, SW:TKT_MYCTU (O06811) (700 aa); Fasta score FT E(): 0, 89.1% identity in 700 aa overlap. Similar to many FT e.g. Saccharomyces cerevisiae tkl2, transketolase 2, FT SW:TKT2_YEAST (P33315) (681 aa); Fasta score E(): 0, 42.8% FT identity in 684 aa overlap. Previously sequenced as FT SW:TKT_MYCLE (P46708) (699 aa); Fasta score E(): 0, 99.9% FT identity in 699 aa overlap. Contains Pfam match to entry FT PF00456 transketolase, Transketolase. Contains PS00801 FT Transketolase signature 1. Contains PS00802 Transketolase FT signature 2." FT /db_xref="GOA:P46708" FT /db_xref="HSSP:1TRK" FT /db_xref="InterPro:IPR005475" FT /db_xref="UniProtKB/Swiss-Prot:P46708" FT /protein_id="CAC30091.1" FT /translation="MTTLDQISTLTQPRHPDDWTEIDSAAVDTIRVLATDAVQKAGNGH FT PGTAMSLAPLAYTLFQRTLRHDPNDTAWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELS FT DIESLRTWGSTTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPG FT ASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEGDTKITLCED FT TAARYRAYGWHVQEVEGGENVVGIEEAIANAKAATDRPSFISLRTIIGYPAPTLINTGK FT AHGAALGEDEVAATKRILGFDPDKTFAVREDVITHTRGLIARGKEAHERWQLEFEAWAQ FT REPERKALLDRLLAQQLPDGWDADLPNWEPRSKELATRAASGAVLSAIGPKLPELWGGS FT ADLAGSNNTTIKDVDSFGPPSISTDEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTR FT AYGGTFLQFSDYMRPSVRLASLMDIDTIYVWTHDSVGLGEDGPTHQPIEHLAALRAIPR FT LSVVRPADANETAYAWRTILARGANSGPVGLILTRQSVPVLEGTNTEGVARGGYVLGDG FT GSSEAKEPDVILIATGSEVQLAVAAQKLLADKDIIVRVVSMPCVEWFESQPYEYRDSVL FT PPSVSARVAVEAGVAQCWHKLVGDTGKIVSIEHYGESADYQTLFREYGFTPEAVVAAAE FT QVLDN" FT misc_feature complement(19638..21611) FT /note="Pfam match to entry PF00456 transketolase, FT Transketolase, score 1459.70, E-value 0" FT misc_feature complement(20166..20216) FT /note="PS00802 Transketolase signature 2" FT misc_feature complement(21552..21614) FT /note="PS00801 Transketolase signature 1" FT RBS complement(21712..21716) FT /note="possible RBS" FT CDS 21904..22869 FT /transl_table=11 FT /gene="ctaB" FT /gene_synonym="ML0584" FT /product="putative protoheme IX farnesyltransferase" FT /note="EC_number=2.5.1.-" FT /note="Similar to M. tuberculosis ctaB, Rv1451, cytochrome FT c oxidase assembly factor, TR:O06809 (EMBL:AL123456) (308 FT aa); Fasta score E(): 0, 82.7% identity in 307 aa overlap. FT Similar to many e.g. Bacillus firmus ctaB, protoheme IX FT farnesyltransferase, SW:COXX_BACFI (Q04444) (312 aa); Fasta FT score E(): 7.8e-24, 33.6% identity in 283 aa overlap. FT Previously sequenced as TR:Q49685 (EMBL:U00013) (300 aa); FT Fasta score E(): 0, 99.7% identity in 300 aa overlap. FT Contains hydrophobic, possible membrane-spanning regions. FT Contains Pfam match to entry PF01040 UbiA, UbiA FT prenyltransferase family." FT /db_xref="GOA:Q9CCN4" FT /db_xref="InterPro:IPR000537" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCN4" FT /protein_id="CAC30092.1" FT /translation="MRSTIVRSRSCALLRSRGVKYVSVRARLARSRVLAYLALTKPRVI FT ELLLVTAIPAMLLADRGSANPLLILNTLLGGISAAAGANTFNCVADADIDKLMKRTSRR FT PLARAAVPPRNALVLGLALTAGSFFWLWWTTNLLSGLLALATVAFYVFVYTLLLKRRTS FT QNVVWGGAAGCMPVMIGWSAITDTIGWPALAMFAIIFFWTPPHTWALAMRYKDDYKVAS FT VPMLPAVATERHVTKQILIYTWLTALSTLVLALATGWLYMAVAVVAGAWFLTMAHQLYV FT GVCAGEPVKPLRLFLQSNNYLAVVFCALAVDSVLALPTLF" FT misc_feature 22036..22845 FT /note="Pfam match to entry PF01040 UbiA, UbiA FT prenyltransferase family, score 360.30, E-value 2e-104" FT CDS complement(22904..23810) FT /pseudo FT /transl_table=11 FT /gene="qor" FT /gene_synonym="ML0585" FT /product="Probable quinone oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT qor (Best blastx score 228)" FT CDS 23832..24694 FT /pseudo FT /transl_table=11 FT /gene="ML0586" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1455 (Best blastx score 414)" FT CDS complement(24668..25603) FT /transl_table=11 FT /gene="ML0587" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv1456c, putative FT membrane protein, TR:O53148 (EMBL:AL123456) (310 aa); Fasta FT score E(): 0, 83.3% identity in 300 aa overlap. Similar to FT bacterial hypothetical proteins e.g. Mycobacterium FT smegmatis fxtF, hypothetical protein, TR:O87318 FT (EMBL:AF027770) (236 aa); Fasta score E(): 0, 67.5% FT identity in 228 aa overlap. Previously sequenced as FT TR:O33142 (EMBL:Z99125) (311 aa); Fasta score E(): 0, 99.7% FT identity in 311 aa overlap. Contains hydrophobic, possible FT membrane-spanning regions." FT /db_xref="GOA:O33142" FT /db_xref="InterPro:IPR003780" FT /db_xref="UniProtKB/TrEMBL:O33142" FT /protein_id="CAC30095.1" FT /translation="MLVGRILLRLVDLIPDPGLRVQRIIAATVLLTQGGITVTGAIVRV FT TASGLGCPTWPQCFPGSFTPVAVTEVPRIHQAVEFGNRVVSIAVVIAALLAVLTVTRAR FT RRTEVRVYAWLMPISTVLQAVIGGITVLTGLLWWTVAIHLLTSMIMVWLAVLLYVKVGE FT PDGGIAYERVIRPLCALTALTAVNLAVVLVTGTLVTAAGPHAGDRSPSRTVPRLRVEIT FT TLAHLHSSLLVAYLALLVGLGFGLLAVGATRAILVRLAVLFALVCAQAAVGTTQYFTGV FT PAALVAVHVAGAAACTAATAALWASMRTRS" FT CDS 25858..26100 FT /transl_table=11 FT /gene="ML0588" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:Q49686 FT (EMBL:U00013) (80 aa); Fasta score E(): 0, 98.8% identity FT in 80 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49686" FT /protein_id="CAC30096.1" FT /translation="MVIGSLDILFLAARPVQLTRTAGQQNDVFVVVAALIEECEHWGLW FT GPAAKETVVQPARLCTLSGDGFGAGPRVAMLPGTW" FT CDS complement(26234..27031) FT /transl_table=11 FT /gene="ML0589" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv1457c, putative FT membrane protein, TR:O86349 (EMBL:AL123456) (261 aa); Fasta FT score E(): 0, 83.1% identity in 260 aa overlap. Similar to FT bacterial hypothetical membrane proteins e.g. Mycobacterium FT smegmatis fxtE, hypothetical membrane protein, TR:O87317 FT (EMBL:AF027770) (236 aa); Fasta score E(): 0, 77.1% FT identity in 236 aa overlap. Previously sequenced as FT TR:Q49703 (EMBL:U00013) (265 aa); Fasta score E(): 0, 99.6% FT identity in 265 aa overlap. Contains hydrophobic, probable FT membrane-spanning regions." FT /db_xref="GOA:Q49703" FT /db_xref="InterPro:IPR013525" FT /db_xref="UniProtKB/TrEMBL:Q49703" FT /protein_id="CAC30097.1" FT /translation="MTQNNTLRNSPLFPAGTFTPNPRPNAVTRMVAAQFMLELKLLLRN FT GEQLLLTMFIPITLLIGLTLLPLGSFGHHRATTFVPVIMALAVVSSAFTGQAIAVAFDR FT RYGALKRFGATPLPVWGIIAGKSLAVVTVVFLQAIILGAIGVMLGWRPALICLALGAAI FT IALGTAGLAALGLLLGGTLRAEIVLAVANLMWFVFAGLGALTVKMNMISAVVKWAARLT FT PSGALTEALSQAMTLSVDWFGVIILTAWGTLAALAALHWFRFT" FT CDS complement(27031..27978) FT /transl_table=11 FT /gene="ML0590" FT /product="putative ABC transporter ATP-binding protein" FT /note="Similar to M. tuberculosis Rv1458c, ABC-transporter FT ATP-binding protein, TR:O53149 (EMBL:AL123456) (313 aa); FT Fasta score E(): 0, 88.0% identity in 308 aa overlap. FT Similar to many e.g. Rhizobium sp. (strain NGR234). nodI, FT nodulation ATP-binding protein I, SW:NODI_RHISN (P55476) FT (343 aa); Fasta score E(): 3.4e-28, 39.4% identity in 317 FT aa overlap. Previously sequenced as TR:Q49707 (EMBL:U00013) FT (315 aa); Fasta score E(): 0, 100.0% identity in 315 aa FT overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC FT transporter. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00211 ABC transporters family FT signature." FT /db_xref="GOA:Q49707" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q49707" FT /protein_id="CAC30098.1" FT /translation="MSSACTVPETPEVVIRLRGVCKHYGSILAVSNLDLDIHSAEVLAL FT LGPNGAGKTTTVEMCEGFVRPDAGTIEVLGLDPITDNARLRARIGVMLQGGGGYPAARA FT GEMLNLVASYAADPLDPEWLLETLGLTDVARTTYRRLSGGQQQRLALACTLVGRPELVF FT LDEPTAGMDTHARLLVWELIDTLRRDGVTVVLTTHQLKEAEELADRLVIIDHGRMIAAG FT TPTELMHTGAKDQLRFSAPPRLDLSLLAFALPEDYKTTELTPGEYLVAGPIDPQVLATV FT TAWCAQINVLTTNMRVEQHSLEDVFLDLTGRKLR" FT RBS complement(27039..27045) FT /note="possible RBS" FT misc_feature complement(27331..27861) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 168.90, E-value 8.6e-47" FT misc_feature complement(27514..27558) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(27817..27840) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(27975..29756) FT /transl_table=11 FT /gene="ML0591" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv1459c, conserved FT hypothetical protein, TR:O53150 (EMBL:AL123456) (591 aa); FT Fasta score E(): 0, 78.6% identity in 585 aa overlap and to FT Rv2174, putative membrane protein, TR:O53508 FT (EMBL:AL123456) (516 aa); Fasta score E(): 2.2e-26, 31.6% FT identity in 513 aa overlap. Previously sequenced as FT TR:Q49695 (EMBL:U00013) (593 aa); Fasta score E(): 0, FT 100.0% identity in 593 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions." FT /note="Similar to ML0899" FT /db_xref="UniProtKB/TrEMBL:Q49695" FT /protein_id="CAC30099.1" FT /translation="MAARHHTLSSSIASLHGDEQAVGSPLNDADRGALQRTRLFGATGT FT ILMAIGALGAGARPVIQDPTFGVRLLNLPSRIQTVSLTMTTTGAVMMTLAWLMLGRFAL FT GRRQMSRGELDRTLLLWTLPLLIAPPMYSKDVYSYLAQSQISLQGLDPYRVGPASALGL FT GQVFTLSVPSLWRETPAPYGPLFLWIGRGISALTGDNIVAAVLCHRLMMLIGVGLVVWA FT TPQLARRCGVVEVSALWLGAANPLLIMHLVAGIHNEAPMLGLMLTGAEFALRGIDFSST FT TRVIPTSWRGGGTGRQHSGTLTSQAIRFGSNWEPLGMLLAGSILIVLSSQVKLPSLLAL FT GFVAMALACRLGSTPQALLMVSLWMAGLSLAVMGIVGWASGLGFGWIYTLGTANVVRSW FT MSPPTLLALGTGHVGILLGLGDHTTAVLSLTRGIGVLIIMVMACWLLLAVFRGRLHPIG FT GLGVALGVTVLLFPVVQPWYLLWAIIPLAAWATRTGFRVAAITVTIVVGVFGPTANGDR FT FALFQIVDATVASTIIVLVLIALTYTRLPWRPLQMVPAKRSELDQQLVRVVAPDPETSQ FT NSASPATRLPTAYANLT" FT CDS 29872..30636 FT /transl_table=11 FT /gene="ML0592" FT /product="putative DNA-binding protein" FT /note="Similar to M. tuberculosis Rv1460, hypothetical FT protein, TR:O53151 (EMBL:AL123456) (278 aa); Fasta score FT E(): 0, 79.6% identity in 250 aa overlap. Similar to other FT bacterial hypothetical proteins e.g. Streptomyces FT coelicolor SCC22.08C, putative DNA-binding protein, FT TR:Q9XAD0 (EMBL:AL096839) (252 aa); Fasta score E(): FT 5.6e-30, 45.4% identity in 216 aa overlap. Previously FT sequenced as TR:Q49688 (EMBL:U00013) (254 aa); Fasta score FT E(): 0, 99.6% identity in 254 aa overlap. Contains a FT probable helix-turn-helix motif at aa 215-236 (Score 1054, FT SD +2.78)" FT /db_xref="GOA:Q49688" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:Q49688" FT /protein_id="CAC30100.1" FT /translation="MLNVHRGYPSLDRSPELRHTGVVKIRSELDAATTVAVSDGHTRRA FT VVRLLLESGSITAGEISDRLGLSAAGVRRHLDVLIEMGDAESATAAPWQQVGRGRPAKH FT YRLTAVGRAKLGHAYDTLASAAMRQLREIGGEDAVRTFARQRIDAILADVEPAGGGADV FT EAAANRVASALSDAGYVATTARVGGPIHGVEICQHHCPVSHVAEEFPELCETEQQAIAE FT VLGTHVQRLAMIVNGDCACTTHVPLMSVPSKT" FT RBS 30674..30681 FT /note="possible RBS" FT CDS 30688..33297 FT /transl_table=11 FT /gene="ML0593" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1461, hypothetical FT protein, SW:YE61_MYCTU (O53152) (846 aa); Fasta score E(): FT 0, 54.3% identity in 920 aa overlap. N- and C-termini are FT similar to various bacterial hypothetical proteins e.g. FT Streptomyces coelicolor SCC22.07C, conserved hypothetical FT protein, TR:Q9XAD1 (EMBL:AL096839) (473 aa); Fasta score FT E(): 0, 45.5% identity in 853 aa overlap. Contains an FT intein from amino acids 202-587 inclusive. The intein is FT different to the one in the M. tuberculosis orthologue and FT at a different relative position. Previously sequenced as FT SW:YE61_MYCLE (Q49689) (869 aa); Fasta score E(): 0, 99.9% FT identity in 869 aa overlap. Contains Pfam match to entry FT PF01458 UPF0051, Uncharacterized protein family (UPF0051). FT Contains PS00881 Protein splicing signature." FT /note="C-terminal half is similar to ML0594" FT /db_xref="GOA:Q49689" FT /db_xref="InterPro:IPR000825" FT /db_xref="UniProtKB/Swiss-Prot:Q49689" FT /protein_id="CAC30101.1" FT /translation="MTRTSETTKSPAPELLTQQQAIDSLGKYGYGWADSDVAGASARRG FT LSEDVVRDISAKKDEPEWMLQARLKALRVFERKPMPRWGSNLDGIDFDNIKYFVRSTEK FT QAASWDELPEDIRNTYDRLGIPDAEKQRLVAGVAAQYESEVVYHQIRADLKDQGVVFLD FT TETGLREYPDIFKQYLGTVIPAGDNKFSALNTAVWSGGCLTADARINVKGKGLVSIADV FT QPGDEVFGVNIGCELERGKVLAKVASGTKPVYEMHVAGRALEATGNHQFLVARRVEEGK FT RTRWTAVWAPLEEIESGEPIAVARVLPDDSGTIFFSESELDIKNRTRQCLYFPCQNSVD FT LLWLLGLWLGDGHTAAPHKHMRQVAFSVPAGDPVHHTAIRVVSEQFGANVTVVNCGFIV FT SSKAFETWLAELGFSGDEKTKRLPAWIYSLPHEHQLALIGGLVDADGWTESSGATMSIA FT FASRELLEDVRQLAIGCGLYPDGALVERTRSATCRDGRIVTSTSWRLRIQGSLDRVGTR FT TPGKRGKPVSNKGRRQRYVAAAGLNFSSLSTDTVGFARLKSKTLVGEKPTYDIQVVGLE FT NFVANGIVAHNSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIADTGSYVHYVEGC FT TAPIYKSDSLHSAVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARVETGATMEWIDGN FT IGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEGQHQDTGAKMLHLASNTSSNIVSKSVAR FT GGGRTSYRGLVQVNKGAHGSRSSVKCDALLVDTISRSDTYPYVDIREDDVTMGHEATVS FT KVSENQLFYLMSRGLAEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG" FT misc_feature 32428..32451 FT /note="PS00881 Protein splicing signature" FT misc_feature 32458..33219 FT /note="Pfam match to entry PF01458 UPF0051, Uncharacterized FT protein family (UPF0051), score 503.40, E-value 1.7e-147" FT RBS 33279..33283 FT /note="possible RBS" FT CDS 33294..34472 FT /transl_table=11 FT /gene="ML0594" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1462, conserved FT hypothetical protein, SW:YE62_MYCTU (O53153) (397 aa); FT Fasta score E(): 0, 80.4% identity in 392 aa overlap. FT Similar to many bacterial hypothetical proteins e.g. FT Streptomyces coelicolor SCC22.06C, conserved hypothetical FT protein, TR:Q9XAD2 (EMBL:AL096839) (394 aa); Fasta score FT E(): 0, 58.6% identity in 365 aa overlap. Previously FT sequenced as SW:YE62_MYCLE (Q49682) (392 aa); Fasta score FT E(): 0, 100.0% identity in 392 aa overlap. Contains Pfam FT match to entry PF01458 UPF0051, Uncharacterized protein FT family (UPF0051)." FT /note="Similar to to the C-terminal half of ML0593" FT /db_xref="GOA:Q49682" FT /db_xref="InterPro:IPR011542" FT /db_xref="UniProtKB/Swiss-Prot:Q49682" FT /protein_id="CAC30102.1" FT /translation="MTAVEGSSLTALNKGRLFASFDVDAFEVPGGRDEIWRFTPLRRLR FT GLHDGSAVANGKVHIRVSQQSGVQTEIVGRGDGRLGQGGIPTDRVAAQAFSSFQSATVV FT TVGRDMQIATPINIAVTGPDKGAVVYGHLQIRVCKFGEAVVVIDHRGSGTYADNVEFIV FT EAAARLTVVWIADWADDMVHLSAHHALLGKDAVLRHITVTLGGEVVRVSANVRFSGPGG FT DAELLGLYFADDGQHLESRLLVDHAHPDCKSNVLYKGALQGDPVSSRPDAHTVWVGDVL FT IHPEATGTDTFEVNRNLVLTNGVRADSVPNLEIETDEIVGAGHASATGRFDDEQLFYLR FT SRGIGEEQARRLLVRGFFGEIISKIAVPQVRERLIAAIEHELTITESRSTAS" FT misc_feature 33588..34376 FT /note="Pfam match to entry PF01458 UPF0051, Uncharacterized FT protein family (UPF0051), score 370.50, E-value 1.7e-107" FT CDS 34469..35251 FT /transl_table=11 FT /gene="ML0595" FT /product="putative ABC transporter ATP-binding protein" FT /note="Similar to M. tuberculosis Rv1463, putative ABC FT transporter ATP-binding protein, TR:O53154 (EMBL:AL123456) FT (266 aa); Fasta score E(): 0, 85.8% identity in 267 aa FT overlap. Similar to many members of the ABC transporter FT family, including members found in chloroplast genomes e.g. FT Cyanophora paradoxa ycf16, probable ATP-dependent FT transporter, SW:ABCX_CYAPA (P48255) (259 aa); Fasta score FT E(): 0, 54.2% identity in 227 aa overlap. Previously FT sequenced as TR:Q49693 (EMBL:U00013) (260 aa); Fasta score FT E(): 0, 100.0% identity in 260 aa overlap. Contains Pfam FT match to entry PF00005 ABC_tran, ABC transporter. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q49693" FT /db_xref="InterPro:IPR010230" FT /db_xref="UniProtKB/TrEMBL:Q49693" FT /protein_id="CAC30103.1" FT /translation="MTTLIVKDLYVSVEHPNAAESECQIPILNGVDLTVKSGETHALMG FT PNGSGKSTLSYAIMGHPKYRVISGAITLDGADVLTMSVDERARAGLFLAMQYPVEVPGV FT SVSNFLRSAATVIRGEPPKLRHWVKEVKAAMGALEIDPVFAERSVNEGFSGGEKKRHEI FT LQLELLKPKIAILDETDSGLDVDALRVVSDGVNRYADSEHGGILLITHYTRILRYIRPE FT FVHVFVGGRIVESGGSELADELEQNGYVRFSQPAATGV" FT misc_feature 34580..35158 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 89.10, E-value 9e-23" FT misc_feature 34601..34624 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT RBS 35243..35246 FT /note="possible RBS" FT CDS 35254..36510 FT /transl_table=11 FT /gene="ML0596" FT /product="putative aminotransferase" FT /note="Similar to M. tuberculosis Rv1464, NifS-like FT protein, TR:O53155 (EMBL:AL123456) (417 aa); Fasta score FT E(): 0, 85.4% identity in 417 aa overlap. Similar to many FT putative aminotransferases and to Anabaena sp. (strain PCC FT 7120) nifS, SW:NIFS_ANASP (P12623) (621 aa); BlastP Expect FT 9.9. Previously sequenced as TR:Q49690 (EMBL:U00013) (418 FT aa); Fasta score E(): 0, 100.0% identity in 418 aa overlap. FT Contains Pfam match to entry PF00266 aminotran_5, FT Aminotransferases class-V. Contains PS00595 FT Aminotransferases class-V pyridoxal-phosphate attachment FT site." FT /note="Similar to part of ML0842 and to ML0117 and ML1708" FT /db_xref="GOA:Q49690" FT /db_xref="HSSP:1KMJ" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:Q49690" FT /protein_id="CAC30104.1" FT /translation="MTISLTPLDLSAIRADFPILKRVMRGGNQLAYLDSGATSQRPVQV FT LDAEREFLVTSNGAVHRGAHQLMEEATDAYERGRVDIAAFIGAAADELVFTKNATESLN FT LVSYVFGDNRFEGTSGDGGDVIVTTELEHHANLIPWQELARRIGATLRWYGVTDDGQID FT LDSLQLDERVKVVAFSHHSNVTGAVAPVRELVARAKEVGALTVLDACQSVPHQPVDLHG FT LGVDFAAFSGHKMLGPNGIGVLYARRELLSVMPPFLTGGSMIETVTMESTTYAPAPQRF FT EAGTPMTSQVVGLAAAARYLDAIGMKAVEAHERELVAAAVEGLSRIDGVRIIGPKSMEN FT RGSPVSFVVDGVHAHDIGQVLDDDGVAVRVGHHCALPLHRRFALAATARASFAVYNTVD FT EVDRLVAGVLRALDFFGRE" FT misc_feature 35374..36465 FT /note="Pfam match to entry PF00266 aminotran_5, FT Aminotransferases class-V, score 5.00, E-value 1.6e-07" FT misc_feature 35926..35985 FT /note="PS00595 Aminotransferases class-V FT pyridoxal-phosphate attachment site" FT RBS 36500..36503 FT /note="possible RBS" FT CDS 36507..37004 FT /transl_table=11 FT /gene="ML0597" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1465, conserved FT hypothetical protein, TR:O53156 (EMBL:AL123456) (162 aa); FT Fasta score E(): 0, 79.4% identity in 165 aa overlap. FT Similar to many hypothetical proteins and shows very weak FT similarity to proteins from N-fixation loci e.g. Anabaena FT azollae nifU, nitrogen fixation protein, SW:NIFU_ANAAZ FT (Q43885) (300 aa); Fasta score E(): 1.9, 24.4% identity in FT 90 aa overlap. Previously sequenced as TR:Q49683 FT (EMBL:U00013) (165 aa); Fasta score E(): 0, 100.0% identity FT in 165 aa overlap. Contains Pfam match to entry PF01883 FT DUF59, Domain of unknown function. Contains Pfam match to FT entry PF01592 NifU_N, NifU-like N terminal domain." FT /db_xref="GOA:Q49683" FT /db_xref="InterPro:IPR011341" FT /db_xref="UniProtKB/TrEMBL:Q49683" FT /protein_id="CAC30105.1" FT /translation="MILRLEQIYQEVILDHYKHPQHRGLREPFCAQVYHVNPICGDEIT FT LRVALSDNGASVADISYEGQGCSISQASISVLAQQVIGQSVPDALNIISAFTEMVSSRG FT TIEGDEDVLGDGVAFAGVAKYPARVKCALLGWMACKDALIHANSADKVLEEVMDEQNHR FT VG" FT misc_feature 36528..36902 FT /note="Pfam match to entry PF01592 NifU_N, NifU-like N FT terminal domain, score 152.10, E-value 9.8e-42" FT RBS 36967..36973 FT /note="possible RBS" FT CDS 36979..37326 FT /transl_table=11 FT /gene="ML0598" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1466, conserved FT hypothetical protein, TR:O53157 (EMBL:AL123456) (115 aa); FT Fasta score E(): 0, 82.6% identity in 115 aa overlap. FT Similar to hypothetical proteins located downstream of FT sigma factor genes in both Streptococcus spp. Previously FT sequenced as TR:Q49691 (EMBL:U00013) (115 aa); Fasta score FT E(): 0, 100.0% identity in 115 aa overlap. Contains Pfam FT match to entry PF01883 DUF59, Domain of unknown function." FT /db_xref="InterPro:IPR002744" FT /db_xref="UniProtKB/TrEMBL:Q49691" FT /protein_id="CAC30106.1" FT /translation="MSKITASGDELLADVEEAMRDVVDPELGINVVDLGLVYGLGLEEG FT KEGMIALVDMTLTSAACPLNDVIEEQSRSALVGSGLVSDLRINWVWNPPWGPDKISDDG FT REQLRALGFTV" FT misc_feature 36985..37296 FT /note="Pfam match to entry PF01883 DUF59, Domain of unknown FT function, score 69.30, E-value 7.9e-17" FT CDS complement(37440..39009) FT /pseudo FT /transl_table=11 FT /gene="fadE15" FT /gene_synonym="ML0599" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE15 (Best blastx score 267)" FT repeat_region 39200..40460 FT /note="LEPRPT, copy 2, 1261 bp" FT repeat_region 40399..40459 FT /note="61 bp repeat found at 3'-end of LEPRPT and situated FT 5' to some copies of REPLEP" FT repeat_region 40495..40901 FT /note="Dispersed repeat, REPLEP, copy 4, truncated at FT 5'-end" FT repeat_region 40495..40946 FT /note="REPLEP region 4, 3'-end most similar to REPLEP 1, 5 FT and 6" FT repeat_region 40902..40946 FT /note="45 bp REPLEP-associated sequence" FT CDS complement(43675..44618) FT /pseudo FT /transl_table=11 FT /gene="ML0600" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of an acyl-CoA dehydrogenase FT homolgous to those in M. tuberculosis (Best blastx score FT 114)" FT CDS 45140..45879 FT /pseudo FT /transl_table=11 FT /gene="ML0601" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2415c (Best blastx score 191)" FT CDS 45927..46848 FT /pseudo FT /transl_table=11 FT /gene="ML0602" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2414c (Best blastx score 167)" FT CDS 47002..48117 FT /transl_table=11 FT /gene="ML0603" FT /product="putative lipoprotein" FT /note="Similar to M. tuberculosis Rv2413c, conserved FT hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); FT Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also FT similar to Streptomyces coelicolor SCC123.02C, putative FT DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); FT Fasta score E(): 0, 39.3% identity in 326 aa overlap. FT Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); FT Fasta score E(): 0, 100.0% identity in 371 aa overlap. FT Contains a possible N-terminal signal sequence. Contains FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site." FT /db_xref="GOA:O33133" FT /db_xref="InterPro:IPR010372" FT /db_xref="UniProtKB/TrEMBL:O33133" FT /protein_id="CAC30111.1" FT /translation="MLVLWRCFRVAMISALMVAVACLPDWLSGFLTGGLIAGSSARRAT FT IYGVSNKFSSLHLVLGNEELLVERAVGEVLRSARQRAGTQDVPVSRMRAGDVGTYELTE FT LLSPSLFADERIVVLEAAAEAGKEAAALIVSAAADIPQGTVLVVVHSGGGRAKALANEL FT QSLGATVHPCARITKLSERTDFVRKELRSLRVKVDEGAVTALLNAVGSDVRELASACSQ FT LVADTAGDVDADAVQRYHSGKAEVKGFDIADKAVGGDVSGAVEALRWAMMRGEPLVVLA FT DALAEAVHTIGRVGPLSGDSYRLASRLGMPPWRVQKAQQQARRWSRDTVAAAMRVVAAL FT NADVKGAAADAYYALESAVRKVAELAADGSR" FT misc_feature 47035..47067 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(48154..48414) FT /transl_table=11 FT /gene="rpsT" FT /gene_synonym="ML0604" FT /product="30S ribosomal protein S20" FT /note="Similar to M. tuberculosis rpsT, 30S ribosomal FT protein S20, SW:RS20_MYCTU (P71731) (86 aa); Fasta score FT E(): 8.8e-27, 87.2% identity in 86 aa overlap. Similar to FT many e.g. Escherichia coli rpsT, 30S ribosomal protein S20, FT SW:RS20_ECOLI (P02378) (86 aa); Fasta score E(): 1.5e-08, FT 41.7% identity in 84 aa overlap. Previously sequenced as FT SW:RS20_MYCLE (O33132) (86 aa); Fasta score E(): 2.1e-30, FT 98.8% identity in 86 aa overlap. Contains Pfam match to FT entry PF01649 Ribosomal_S20p, Ribosomal protein S20." FT /db_xref="GOA:O33132" FT /db_xref="InterPro:IPR002583" FT /db_xref="UniProtKB/Swiss-Prot:O33132" FT /protein_id="CAC30112.1" FT /translation="MTNIKSQQKRNRTNERARLRNKSVKSSLRTAVRAFREAVHAGEKE FT KAAKLLVSTSRKLDKAASKGVIHKNQAANKKSALARTLNKL" FT misc_feature complement(48160..48411) FT /note="Pfam match to entry PF01649 Ribosomal_S20p, FT Ribosomal protein S20, score 151.30, E-value 1.7e-41" FT RBS complement(48424..48429) FT /note="possible RBS" FT RBS 48541..48544 FT /note="possible RBS" FT CDS 48549..50234 FT /transl_table=11 FT /gene="ML0605" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2411c, conserved FT hypothetical protein, SW:YO11_MYCTU (P71732) (551 aa); FT Fasta score E(): 0, 87.4% identity in 554 aa overlap. FT Similar to other bacterial hypothetical proteins. This CDS FT and the downstream CDS are also similar to the N- and FT C-terminal regions respectively, of longer hypothetical FT proteins from M. tuberculosis and M. leprae e.g. M. FT tuberculosis Rv2567, SW:YP67_MYCTU (Q50654) (884 aa); Fasta FT score E(): 0, 32.2% identity in 537 aa overlap. Contains a FT Gln-rich region at the C-terminus. Previously sequnced as FT SW:YO11_MYCLE (Q49755) (561 aa); Fasta score E(): 0, 100.0% FT identity in 561 aa overlap." FT /note="Similar to the N-terminal region of ML2679" FT /db_xref="InterPro:IPR016450" FT /db_xref="UniProtKB/Swiss-Prot:Q49755" FT /protein_id="CAC30113.1" FT /translation="MSQVSLPSQLKETGPRLQSRCRSSARSERIFGGYNTSDIYSMAFD FT EMFDVQGNVRGPYKGIYAELAPSDASELKARAEALARAFIDQGITFSLSGQERPFPLDL FT VPRVISASEWSRLERGITQRVKALEMYLDDIYGDQEILRDGVIPRRLITSCEHFHRQAV FT GIIPPNGVRIHVAGIDLIRDDSGNFRVLEDNLRSPSGVSYVMENRRTIARVFPNLFATH FT RVRAVDDYASHLLRALRNSAATNEADPTVVVLTPGVANAAYFEHSLLARQMGVELVEGR FT DLFCRDNQVYMCTTEGERQVDVIYRRIDDAFLDPLQFRADSVLGVAGLVNAARAGNVVI FT SSAIGNGVGDDKLVYTYVPTMMEYYLREKPLLANVDTLRCWLDDERQEVLDRIHDLVLK FT PVEGSGGYGIVFGPDASEKELAAASKKIRDDPRSWIAQPVMELSTVPTQVGSTLAPRYV FT DLRPFAVNDGNDVWVLPGGLTRVALVEGSRVVNSSQGGGSKDTWVLAPHASYGARELGA FT AEIVCSLPQSSPDPVPDGSPRPKQQPQQAQAEQAQQPQQQIMLP" FT CDS 50234..51211 FT /transl_table=11 FT /gene="ML0606" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2410c, conserved FT hypothetical protein, TR:P71733 (EMBL:AL123456) (325 aa); FT Fasta score E(): 0, 90.8% identity in 325 aa overlap. FT Similar to other bacterial hypothetical proteins. This CDS FT and the upstream CDS are also similar to the C- and FT N-terminal regions respectively, of longer hypothetical FT proteins from M. tuberculosis and M. leprae e.g. M. FT tuberculosis Rv2567, SW:YP67_MYCTU. Previously sequnced as FT TR:Q49770 (EMBL:U00016) (325 aa); Fasta score E(): 0, FT 100.0% identity in 325 aa overlap." FT /note="Similar to the C-terminal region of ML2679" FT /db_xref="InterPro:IPR007296" FT /db_xref="UniProtKB/TrEMBL:Q49770" FT /protein_id="CAC30114.1" FT /translation="MLARNAEALYWIGRYVERADDTARILDVVVHQLLEDSSVDPDHAS FT RTLLRVLGIELPDHELDVWSLTDLVAFSTNAQGGSSIVDAISAARENAKSAREVTSSET FT WECLNTTYHALAERERAAKRLGPHEFLSFIEGRAAMFAGLADSTLSRDDGYRFMLLGRA FT IERVDMTVRLLLSRVGDSASSPAWVTLLRSAGGHDTYLRTYRGVLDAARVVEFMLLDRL FT FPRSIFYSLKLAEHNLDELLRNPQSRVGATTEAQRLLGQARSELEFVQPGVLLKTLDSR FT LASLQTTCRDVGDALVLQYFHVAPWVAWSDAGHRGRMVGKRGEA" FT RBS 51200..51203 FT /note="possible RBS" FT CDS 51211..52050 FT /transl_table=11 FT /gene="ML0607" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2409c, conserved FT hypothetical protein, TR:P71734 (EMBL:AL123456) (279 aa); FT Fasta score E(): 0, 82.1% identity in 279 aa overlap and to FT Rv2569c, hypothetical protein, SW:YP69_MYCTU (Q50652) (314 FT aa); Fasta score E(): 4.1e-13, 33.0% identity in 300 aa FT overlap. Similar to other bacterial hypothetical proteins FT e.g. Deinococcus radiodurans DR1993, conserved hypothetical FT protein, TR:Q9RSX6 (EMBL:AE002037) (274 aa); Fasta score FT E(): 8.2e-25, 33.6% identity in 280 aa overlap. Previously FT sequnced as SW:YP69_MYCLE (U00016) (279 aa); Fasta score FT E(): 0, 100.0% identity in 279 aa overlap. Contains Pfam FT match to entry PF01841 Transglut_core, FT Transglutaminase-like superfamily." FT /note="Similar to ML0508" FT /db_xref="InterPro:IPR002931" FT /db_xref="UniProtKB/Swiss-Prot:Q49757" FT /protein_id="CAC30115.1" FT /translation="MWRMRVVHSTGYVYESPATASFNEARLTPRSNTRQTVILNRVETI FT PATRSYRYIDYWGTVVTAFDLRAPHTELTVTSSSVVETESLEPSVSRITWTELQSMAVI FT DRFDEVLQPTAYTPVNTRVAAVGKRIAKNHEPRKAVVAAARWARSKLDYIPGTTGVHSS FT GLDALHQCRGVCQDFAHLTLIVLRSMGIPGRYVSGYLHPKRDAVVGKTVEGRSHAWIQA FT WTGGWWNYDPTNDVEITEQYISVGVGRDYTDVAPLKGIYSGRGATDLDVVVEITRLA" FT misc_feature 51718..51909 FT /note="Pfam match to entry PF01841 Transglut_core, FT Transglutaminase-like superfamily, score 78.40, E-value FT 1.4e-19" FT CDS complement(52723..53531) FT /pseudo FT /transl_table=11 FT /gene="ML0608" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2407 (Best blastx score 558)" FT CDS 53778..53991 FT /pseudo FT /transl_table=11 FT /gene="ML0609" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2406c (Best blastx score 134)" FT CDS complement(54052..54614) FT /pseudo FT /transl_table=11 FT /gene="ML0610" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2405 (Best blastx score 219)" FT CDS 54716..56656 FT /transl_table=11 FT /gene="lepA" FT /gene_synonym="ML0611" FT /product="putative GTP-binding protein" FT /note="Similar to M. tuberculosis lepA, Rv2404c, putative FT GTP-binding protein, SW:LEPA_MYCTU (P71739) (653 aa); Fasta FT score E(): 0, 88.0% identity in 649 aa overlap. Similar to FT many e.g. Bacillus subtilis lepA, GTP-binding protein, FT SW:LEPA_BACSU (P37949) (612 aa); Fasta score E(): 0, 56.8% FT identity in 613 aa overlap. Previously sequenced as FT SW:LEPA_MYCLE (P53530) (646 aa); Fasta score E(): 0, 99.8% FT identity in 646 aa overlap. Contains Pfam match to entry FT PF00009 GTP_EFTU, Elongation factor Tu family. Contains FT PS00301 GTP-binding elongation factors signature. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="Show weak imilarity to ML1498, ML1877 and ML1878" FT /db_xref="GOA:P53530" FT /db_xref="HSSP:2EFG" FT /db_xref="InterPro:IPR004161" FT /db_xref="UniProtKB/Swiss-Prot:P53530" FT /protein_id="CAC30119.1" FT /translation="MSWSLRVDKPDTGESPFKHSLVTGAQEIPISSFADKTFTAPAQIR FT NFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQYLDRMDIERERGITIKAQNVRLSWS FT VTAGGTTENYVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAVQGIEAQTLANLYLAL FT ERDLTIIPVLNKIDLPAADPDRYAAEIAHIIGYESGDVLRVSGKTGEGVSDLLDEVVRR FT VPHPQGDPDAPTRAMIFDSVYDIYRGVVTYVRVVDGKISPRERIAMMSTGATYELLEVG FT IVSPEPKASAGLGVGEVGYLITGVKDVRQSKVGDTVTTVRYGATEPLTGYREPKPMVYS FT GLYPVDSSDYPSLRDALGKLQLNDAALTYEPETSVALGVGYRCGFLGLLHIDITRERLE FT REFDLDLISTSPNVVYRVVTEDNTEIVVTNPSDWPEGKIRTVYEPVVKITIIAPSEFIG FT TIMELCQSRRGELGGMDYLSPERVELRYIMPLGEIIFDFFDSLKSRTRGYASLDYEEAG FT EQEAQLVKVDILLQGEAVDAFSAIVHKDSASAYGNKMTNKLKELIPRQQFEVPVQAAIG FT SKVIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAAL FT SADAAGDKDKK" FT misc_feature 54839..55975 FT /note="Pfam match to entry PF00009 GTP_EFTU, Elongation FT factor Tu family, score 325.50, E-value 6.1e-94" FT misc_feature 54866..54889 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 54959..55006 FT /note="PS00301 GTP-binding elongation factors signature" FT CDS complement(56738..58654) FT /pseudo FT /transl_table=11 FT /gene="ML0612" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2402 (Best blastx score 1589)" FT CDS complement(58875..59774) FT /pseudo FT /transl_table=11 FT /gene="ML0613" FT /product="possible hydroxylase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT Rv1751 (Best blastx score 134)" FT CDS 59777..60064 FT /transl_table=11 FT /gene="ML0614" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:Q49760 FT (EMBL:U00016) (95 aa); Fasta score E(): 0, 100.0% identity FT in 95 aa overlap." FT /db_xref="GOA:Q49760" FT /db_xref="UniProtKB/Swiss-Prot:Q49760" FT /protein_id="CAC30122.1" FT /translation="MWKARTALGDLDTVFYDAGTANGTNGISVSPVNGFLNWWDSIELW FT LSGLAFVLQAALVMPVVLAFAYGTALVLDFALGKGIQLMRRAYHPDSARG" FT CDS 60382..61428 FT /transl_table=11 FT /gene="subI" FT /gene_synonym="ML0615" FT /product="putative sulphate-binding protein" FT /note="Similar to M. tuberculosis subI, Rv2400c, putative FT sulphate binding protein, TR:P71744 (EMBL:AL123456) (356 FT aa); Fasta score E(): 0, 76.5% identity in 340 aa overlap. FT Similar to many e.g. Escherichia coli sbp, sulfate-binding FT protein precursor, SW:SUBI_ECOLI (P06997) (329 aa); Fasta FT score E(): 1.2e-28, 35.7% identity in 291 aa overlap. FT Previously sequenced as TR:Q49748 (EMBL:U00016) (358 aa); FT Fasta score E(): 0, 100.0% identity in 348 aa overlap. FT Contains Pfam match to entry PF01100 Sulphate_bind, FT Prokaryotic sulphate- and thiosulphate-binding protein." FT /db_xref="GOA:Q9CCN3" FT /db_xref="HSSP:1SBP" FT /db_xref="InterPro:IPR006059" FT /db_xref="UniProtKB/TrEMBL:Q9CCN3" FT /protein_id="CAC30123.1" FT /translation="MFKDIGRFMRWRHSMVVGVTLASTTDVVAACHGGASDVVGGGTAH FT AHTSIALVAYSAPGPGWGKVIPAFNDARSGDGVQVVTSYGASGDQSRGVVDGKPADIVN FT FSVETDITRLVKVGKVSKDWDTDATKGIPFGSVVTLVVRTGNPKNIKDWDDLVRPGVEV FT IMPNPLSSGSAKWNLLAPYAAKSEGCRNSQAGIDFVNRLVAEHVKLRLGSAREATDAFV FT QGSGDVLISYENEAIAAERQGKPVEHINPPVTFKIENPLAVVSTSAHLEVATAFKNFQY FT TTAAQGLWAQAGFRPVDPAVSADFSDQFPAPVKLWTIADLGGWSTVDPQLFDKNTGSIT FT KVYMQATG" FT misc_feature 60406..61416 FT /note="Pfam match to entry PF01100 Sulphate_bind, FT Prokaryotic sulphate- and thiosulphate-binding protein, FT score 211.20, E-value 1.6e-59" FT CDS 61509..62255 FT /pseudo FT /transl_table=11 FT /gene="cysT" FT /gene_synonym="ML0616" FT /product="sulphate transport system permease protein FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT cysT (Best blastx score 386)" FT CDS 62258..62925 FT /pseudo FT /transl_table=11 FT /gene="cysW" FT /gene_synonym="ML0617" FT /product="sulphate transport system permease protein FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT cysW (Best blastx score 281)" FT CDS 63047..63488 FT /pseudo FT /transl_table=11 FT /gene="cysA" FT /gene_synonym="ML0618" FT /product="sulphate transport ATP-binding protein FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT cysA (Best blastx score 153)" FT CDS complement(63913..64428) FT /pseudo FT /transl_table=11 FT /gene="ML0619" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2387 (Best blastx score 213)" FT CDS 65532..66035 FT /transl_table=11 FT /gene="mtb12" FT /gene_synonym="ML0620" FT /product="putative secreted protein" FT /note="Similar to M. tuberculosis mtb12, Rv2376c, low FT molecular weight antigen, SW:MB12_MYCTU (O05822) (168 aa); FT Fasta score E(): 0, 65.5% identity in 165 aa overlap. FT Previously sequenced as SW:MB12_MYCLE (Q49771) (165 aa); FT Fasta score E(): 0, 100.0% identity in 165 aa overlap. M. FT tuberculosis mtb12 is secreted, therefore this protein may FT also be secreted." FT /db_xref="GOA:Q49771" FT /db_xref="InterPro:IPR020235" FT /db_xref="UniProtKB/Swiss-Prot:Q49771" FT /protein_id="CAC30128.1" FT /translation="MTMKSIATYAALAIIGAAVDGLTSMAIPTGPAASHIQPVAFGVPL FT PQDPAPAADVPTAAELTSLLNKIVDPDVSFMHKSQLVEGGIGSAEAHIGDRELKNAAQK FT GELPLLFSVTNIRPGTSGSATADVSVSGPKLNPPVTQNITFINKGSWVLSRHSAMELLQ FT AAGR" FT CDS complement(66090..66773) FT /pseudo FT /transl_table=11 FT /gene="ML0621" FT /product="ECF family sigma factor (pseudogene)" FT /note="Possible pseudogene of gene similar to M. FT tuberculosis sigI gene (Best blastx score 110)" FT repeat_region complement(66310..66472) FT /note="163 bp repeat, 96% identical to region FT 982996..983158 " FT CDS complement(66965..67390) FT /pseudo FT /transl_table=11 FT /gene="ML0622" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3327 (Best blastx score 106)" FT CDS complement(67666..67984) FT /pseudo FT /transl_table=11 FT /gene="ML0623" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2375 (Best blastx score 230)" FT RBS 68753..68761 FT /note="possible RBS" FT CDS 68770..69801 FT /transl_table=11 FT /gene="hrcA" FT /gene_synonym="ML0624" FT /product="putative heat-inducible transcription repressor" FT /note="Similar to M. tuberculosis hrcA, Rv2374c, FT heat-inducible transcription repressor, SW:HRCA_MYCTU FT (O05824) (343 aa); Fasta score E(): 0, 89.5% identity in FT 343 aa overlap. Similar to many e.g. Bacillus FT stearothermophilus, hcrA, heat-inducible transcription FT repressor, SW:HRCA_BACST (Q45550) (344 aa); Fasta score FT E(): 3.5e-26, 28.3% identity in 336 aa overlap. Previously FT sequenced as TR:Q49749 (EMBL:U00016) (197 aa); Fasta score FT E(): 0, 99.5% identity in 196 aa overlap. Contains Pfam FT match to entry PF01628 HrcA, HrcA protein." FT /db_xref="GOA:Q9CCN2" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCN2" FT /protein_id="CAC30132.1" FT /translation="MGNADERRFEVLRAIVADFVATKEPIGSRALVERHNLGVSSATIR FT NDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLEDVKPLSAAERRAIQSFLESGVDL FT DDVLRRAVRLLAQLTCQVAVVQYPTLSTSTVRHLEVIALSPARLLMVVITESGRVDQRI FT AELGDVIDDYQLSQLREMLSQAMGGKKLSAASAAVADLVGRFRGTGGLANAVGRSANVL FT LESLVEHTEERLLLGGTANLTRNSADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTV FT RIGHETAAEQIMGTSMVSTAYGTSGTVYGGMGVLGPTRMDYPGTIASVAAVALYIGEVL FT GAR" FT misc_feature 68776..69768 FT /note="Pfam match to entry PF01628 HrcA, HrcA protein, FT score 472.40, E-value 3.6e-138" FT RBS 69860..69865 FT /note="possible RBS" FT CDS 69873..71009 FT /transl_table=11 FT /gene="dnaJ2" FT /gene_synonym="ML0625" FT /product="DnaJ homologue" FT /note="Similar to M. tuberculosis dnaJ2, Rv2373c, DnaJ2 FT protein, TR:O05825 (EMBL:AL123456) (382 aa); Fasta score FT E(): 0, 88.0% identity in 382 aa overlap. Similar to many FT e.g. Escherichia coli dnaJ, Dna protein, SW:DNAJ_ECOLI FT (P08622) (375 aa); Fasta score E(): 0, 40.6% identity in FT 382 aa overlap. Previously sequenced as TR:Q49762 FT (EMBL:U00016) (378 aa); Fasta score E(): 0, 99.7% identity FT in 378 aa overlap. Contains Pfam match to entry PF01556 FT DnaJ_C, DnaJ C terminal region. Contains Pfam match to FT entry PF00684 DnaJ_CXXCXGXG, DnaJ central domain (4 FT repeats). Contains Pfam match to entry PF00226 DnaJ, DnaJ FT domain." FT /note="Similar to ML2494" FT /db_xref="GOA:Q49762" FT /db_xref="HSSP:1HDJ" FT /db_xref="InterPro:IPR001305" FT /db_xref="UniProtKB/Swiss-Prot:Q49762" FT /protein_id="CAC30133.1" FT /translation="MARDYYGLLGVSRNASDADIKRAYRKLARELHPDINPDEAAQAKF FT KEISMAYEVLSDPEKRRIVDLGGDPMENAAASPSGFGGFGGLGDVFEAFFGGSSASRGP FT IGRVRPGSDSLLPMWLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSAPIPCDTCGG FT RGEVQTVQRSLLGQMVTARPCPTCRGVGVVIPDPCCQCVGDGRVRARREITVKIPSGVG FT DGMRVRLAAQGEVGPGGGPAGDLYVEVHEQAHDIFVRDGDDLHCTVSVPMVDAALGTTI FT TVDAILDGMSEIDISPGTQPGSVIELRGQGMPHLRSNTRGNLHVHVEVMVPTRLDQHDT FT ELLRELKRRRSRDVAEVRSTHAAGGGLFSRLRETFTNR" FT misc_feature 69882..70076 FT /note="Pfam match to entry PF00226 DnaJ, DnaJ domain, score FT 131.40, E-value 1.6e-35" FT misc_feature 70254..70508 FT /note="Pfam match to entry PF00684 DnaJ_CXXCXGXG, DnaJ FT central domain (4 repeats), score 70.80, E-value 2.9e-17" FT misc_feature 70545..70913 FT /note="Pfam match to entry PF01556 DnaJ_C, DnaJ C terminal FT region, score 229.20, E-value 6.1e-65" FT CDS 71041..71814 FT /transl_table=11 FT /gene="ML0626" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2372c, conserved FT hypothetical protein, TR:O05826 (EMBL:AL123456) (262 aa); FT Fasta score E(): 0, 76.9% identity in 255 aa overlap. FT Similar to many bascterial hypothetical proteins e.g. FT Streptomyces coelicolor sdrD, hypothetical protein, FT TR:Q9S3Y4 (EMBL:AF170561) (216 aa); Fasta score E(): FT 1.2e-28, 44.8% identity in 223 aa overlap. Previously FT sequenced as TR:Q49763 (EMBL:U00016) (128 aa); Fasta score FT E(): 0, 100.0% identity in 126 aa overlap." FT /db_xref="GOA:Q9CCN1" FT /db_xref="HSSP:1VHK" FT /db_xref="InterPro:IPR006700" FT /db_xref="UniProtKB/TrEMBL:Q9CCN1" FT /protein_id="CAC30134.1" FT /translation="MVSTLFYVDALPDTGTVAVVGGDEGFHAVTVRRIRPGEELVLGDG FT VGGLAHCLVERAGRDGLYARVLGHWTVAPGLPPATVVQALPKAERSELAIEMATEAGAD FT AFVAWQSDRCVASWYGVRVDKGLRRWRAVARAAARQSRRAHIPSVDGVLTTAALLQRIR FT DEVAAGATVLALHESATDRLSDVFADISVAQANSLVLLVGPEGGIAPDEIAALTEAGAV FT AVRLGPTVLRSSTAAAVALGALGVLTSRWDASSIL" FT CDS 72114..73163 FT /transl_table=11 FT /gene="phoH" FT /gene_synonym="ML0627" FT /product="phoH-family protein" FT /note="Similar to M. tuberculosis phoH, Rv2372c, FT phoH-family protein, SW:PHOL_MYCTU (O05830) (352 aa); Fasta FT score E(): 0, 88.9% identity in 352 aa overlap. Similar to FT many hypothetical proteins and to Escherichia coli phoH, FT phosphate starvation-inducible protein, SW:PHOH_ECOLI FT (P31544) (354 aa); Fasta score E(): 1.2e-29, 36.8% identity FT in 304 aa overlap. Previously sequenced as SW:PHOL_MYCLE FT (Q49751) (349 aa); Fasta score E(): 0, 99.7% identity in FT 349 aa overlap. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop)." FT /note="Similar to ML1951, except and N- and C-termini" FT /db_xref="GOA:Q49751" FT /db_xref="InterPro:IPR003714" FT /db_xref="UniProtKB/Swiss-Prot:Q49751" FT /protein_id="CAC30135.1" FT /translation="MTHHETSAVDASSASMHVRSTIDVPPDLVVGLLGSADENLRALER FT MLSADLHVRGNTVAFSGEPADVALAERAISELVAIVASGHPLTPEVVRHGVAMLVGTGN FT ESPAEVLTLDILLRRGKTVRPKTLNQKRYVDAIDANTIVFGIGPAGTGKTYLAMAKAVN FT ALQTKQVTRIILTRPAVEAGERLGFLPGTLSEKIDPYLRPLYDALYDMMDPELIPKLMS FT SGVIEVASLAYMRGRTLNDAFIVLDEAQNTTAEQMKMFLTRLGFGSKVVVTGDVTQIDL FT PGGARSGLRAAVDILEHIDDIYVAELASVDVVRHRLVSEIVDAYAEYEEHDLGMNRAAR FT RASGARNRR" FT misc_feature 72552..72575 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 73194..73730 FT /transl_table=11 FT /gene="ML0628" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2367c, hypothetical FT protein, SW:YN67_MYCTU (O05831) (182 aa); Fasta score E(): FT 0, 89.1% identity in 175 aa overlap. Similar to many FT bacterial hypothetical proteins e.g. Streptomyces FT coelicolor SCC117.06, hypothetical protein, TR:CAB66427 FT (EMBL:AL136534) (165 aa); Fasta score E(): 1e-31, 54.5% FT identity in 154 aa overlap. Similar to Streptococcus mutans FT dgk, diacyglycerol kinase, TR:O51806 (EMBL:AF000954) (164 FT aa); Fasta score E(): 3.8e-07, 30.9% identity in 162 aa FT overlap. Previously sequenced as SW:YN67_MYCLE (Q49752) FT (178 aa); Fasta score E(): 0, 100.0% identity in 178 aa FT overlap. Contains Pfam match to entry PF02130 UPF0054, FT Uncharacterized protein family UPF0054. Contains PS01306 FT Uncharacterized protein family UPF0054 signature." FT /db_xref="GOA:Q49752" FT /db_xref="InterPro:IPR002036" FT /db_xref="UniProtKB/Swiss-Prot:Q49752" FT /protein_id="CAC30136.1" FT /translation="MSVEVSNESGFDVSEVELVSVARFVIIKMDVNPAAELSMVLLDTA FT AMADLHMRWMDLPGPTDVMSFPMDEFEPGGRPDAAEPGPSMLGDIVLCPEFAAQQAAAE FT GHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFALQGRLLEEWVAEQVRAYQHDRQNE FT KDCRLLYKSGYFGYL" FT misc_feature 73311..73631 FT /note="Pfam match to entry PF02130 UPF0054, Uncharacterized FT protein family UPF0054, score 235.30, E-value 8.7e-67" FT misc_feature 73545..73577 FT /note="PS01306 Uncharacterized protein family UPF0054 FT signature" FT CDS 73727..75012 FT /pseudo FT /transl_table=11 FT /gene="ML0629" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2366c (Best blastx score 651)" FT RBS 75019..75023 FT /note="possible RBS" FT CDS 75032..75358 FT /transl_table=11 FT /gene="ML0630" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2365c, hypothetical FT protein, TR:O05833 (EMBL:AL123456) (113 aa); Fasta score FT E(): 1.5e-22, 67.9% identity in 106 aa overlap. Similar to FT Streptomyces coelicolor SCC77.05, hypothetical protein, FT TR:Q9RDF3 (EMBL:AL136503) (132 aa); Fasta score E(): FT 3.3e-06, 39.4% identity in 99 aa overlap. Previously FT sequenced as TR:Q49767 (EMBL:U00016) (108 aa); Fasta score FT E(): 0, 100.0% identity in 108 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49767" FT /protein_id="CAC30138.1" FT /translation="MAELLNTEDAKLVVLVRAAMARTEAGSGAVVRDFDGRTYAAAPVT FT LSTLELIGLQEEAAAAFSASSVVSGLEVGVLVAGSVDEPDIAMVRELASTAVVILIDRN FT GNRV" FT CDS 75476..76384 FT /transl_table=11 FT /gene="era" FT /gene_synonym="ML0631" FT /product="putative Era-family GTP-binding protein" FT /note="Similar to M. tuberculosis era, Rv2364c, GTP-binding FT protein Era homolog, SW:ERA_MYCTU (O05834) (300 aa); Fasta FT score E(): 0, 81.4% identity in 301 aa overlap. Similar to FT many bacterial era-homologues and to Escherichia coli era, FT GTP-binding protein, SW:ERA_ECOLI (P06616) (301 aa); Fasta FT score E(): 3.3e-30, 34.3% identity in 297 aa overlap. FT Previously sequenced as SW:ERA_MYCLE (Q49768) (302 aa); FT Fasta score E(): 0, 99.7% identity in 302 aa overlap. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q49768" FT /db_xref="HSSP:1MKY" FT /db_xref="InterPro:IPR005225" FT /db_xref="UniProtKB/Swiss-Prot:Q49768" FT /protein_id="CAC30139.1" FT /translation="MDMAEFRSGFVCLIGRPNTGKSTLTNALVGTKVAITSMKPQTTRH FT TIRGIVHREGNFQIVLVDTPGLHRPRTLLGKRLNDLVRDTYTEVDLIGLCIPADEATGP FT GDRWIVNQIRSVAPKTILVVIVTKIDKVPKDRLSAQLVAVSDLVADSAEIVPVSAVTGE FT QVDVLIDVLAAALPPGPAYYSAGELTDEPEELLMAELIREAVLEGVHDELPHSLAVVID FT EVSPRAGRGDLIDVHAVLYVERPSQKGIVIGKSGARLREVGIAARRQIEKLLGTNIYLD FT LHVNVAKNWQRNPKQLGRLGF" FT misc_feature 75518..75541 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(76433..77812) FT /pseudo FT /transl_table=11 FT /gene="amiA2" FT /gene_synonym="ML0632" FT /product="putative amidase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT amiA2 (Best blastx score 975)" FT CDS 77911..78717 FT /transl_table=11 FT /gene="ML0633" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2362c, conserved FT hypothetical protein, TR:O05836 (EMBL:AL123456) (265 aa); FT Fasta score E(): 0, 86.6% identity in 268 aa overlap. FT Similar to Streptomyces coelicolor SCC121.13C, hypothetical FT protein, TR:CAB69731 (EMBL:AL137166) (251 aa); Fasta score FT E(): 0, 52.8% identity in 248 aa overlap. Shows weak FT similarity, except at C-terminus to Bacillus subtilis recO, FT DNA repair protein, SW:RECO_BACSU (P42095) (255 aa); Fasta FT score E(): 5.3e-11, 27.3% identity in 176 aa overlap. FT Previously sequenced as TR:Q49754 (EMBL:U00016) (269 aa); FT Fasta score E(): 0, 100.0% identity in 268 aa overlap." FT /db_xref="GOA:Q9CCN0" FT /db_xref="InterPro:IPR003717" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCN0" FT /protein_id="CAC30141.1" FT /translation="MRLYRDWALVLRQHNLGEADRIVTLLTRDHGLVRAVAKGVRRTRS FT KFGARLEPFAYIDAQLHPGRNLDIVTQVVSIDAFATDIVSDYGRYTCGCAMLETAERLA FT GEERAPAPTLHRLTVSALRAVADGNRPRDLLLDAYLLRAMGIAGWAPALTACARCATPG FT PHRAFHIAAGGSVCVHCRPAGSTTPPRGVLELMSALHDGDWGTAQQAPQSHRSYASGLV FT AAHLQWHLERQLKTLPLVERTHQAYQVDRSIAERRAALVRQDMACG" FT CDS 78710..79600 FT /transl_table=11 FT /gene="ML0634" FT /product="putative undecaprenyl pyrophosphate synthetase" FT /EC_number="2.5.1.31" FT /note="Similar to M. tuberculosis Rv2361c, putative FT undecaprenyl pyrophosphate synthetase, SW:UPPS_MYCTU FT (O05837) (296 aa); Fasta score E(): 0, 86.5% identity in FT 296 aa overlap. Similar to many e.g. Micrococcus luteus FT uppS, undecaprenyl pyrophosphate synthetase, SW:UPPS_MICLU FT (O82827) (249 aa); Fasta score E(): 5.4e-30, 39.4% identity FT in 246 aa overlap. Previously sequenced as SW:UPPS_MYCLE FT (P38119) (296 aa); Fasta score E(): 0, 99.7% identity in FT 296 aa overlap. Contains Pfam match to entry PF01255 FT UPP_synthetase, Putative undecaprenyl diphosphate synthase. FT Contains PS01066 Undecaprenyl pyrophosphate synthetase FT family signature." FT /note="Similar to ML2467" FT /db_xref="GOA:P38119" FT /db_xref="HSSP:1JP3" FT /db_xref="InterPro:IPR018520" FT /db_xref="UniProtKB/Swiss-Prot:P38119" FT /protein_id="CAC30142.1" FT /translation="MVRNERTLKSTDFPQLPPAPDDYPTFPDKSTWPVVFPMLPPSPDG FT GPRRPPQHTSKAVAPRLSAAQLPTHVAIVMDGNGRWANQRGLHRTEGHKMGEAVVIDVA FT CGAIELGIKWLSLYAFSTENWKRSVEEVRFLMGFNRDVVRRRRENLKEMGVRIRWVGSR FT PRLWRSVINELAIAEHMTAGNDVITINYCVNYGGRTEIAEATREIARLAAAGRLNPERI FT TESTITRHLQRPDIPDVDLFVRTSGEQRSSNFMLWQAAYTEYIFQDKLWPDYDRRDLWA FT ACEEYASRNRRFGSA" FT misc_feature 78929..79594 FT /note="Pfam match to entry PF01255 UPP_synthetase, Putative FT undecaprenyl diphosphate synthase, score 487.70, E-value FT 8.8e-143" FT misc_feature 79427..79480 FT /note="PS01066 Undecaprenyl pyrophosphate synthetase family FT signature" FT CDS 79600..79932 FT /pseudo FT /transl_table=11 FT /gene="ML0635" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2360c (Best blastx score 192)" FT CDS complement(79995..80473) FT /pseudo FT /transl_table=11 FT /gene="ML0636" FT /product="lipoprotein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis lpqQ FT (Best blastx score 118)" FT CDS complement(80879..80986) FT /pseudo FT /transl_table=11 FT /gene="ML0636A" FT /product="hypothetical protein (pseudogene)" FT /note="ML0636A. Possible pseudogene similar to M. FT tuberculosis Rv3198 A (84 aa). (Best blastx score 132)" FT CDS 81118..83271 FT /transl_table=11 FT /gene="uvrD2" FT /gene_synonym="ML0637" FT /product="putative ATP-dependent DNA helicase" FT /note="Similar to M. tuberculosis uvrD2, Rv3198c, putative FT ATP-dependent DNA helicase, SW:UVRD_MYCTU (O53344) (700 FT aa); Fasta score E(): 0, 82.9% identity in 706 aa overlap. FT Similar to many e.g. Escherichia coli uvrD, DNA helicase FT II, SW:UVRD_ECOLI (P03018) (720 aa); Fasta score E(): FT 1.1e-20, 32.6% identity in 660 aa overlap. Previously FT sequenced as SW:UVRD_MYCLE (P53528) (457 aa); Fasta score FT E(): 0, 100.0% identity in 439 aa overlap. Contains Pfam FT match to entry PF00570 HRDC, HRDC domain. Contains Pfam FT match to entry PF00580 UvrD-helicase, UvrD/REP helicase. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="ML0153" FT /db_xref="GOA:P53528" FT /db_xref="HSSP:1PJR" FT /db_xref="InterPro:IPR002121" FT /db_xref="UniProtKB/Swiss-Prot:P53528" FT /protein_id="CAC30146.1" FT /translation="MDPMVMVVNPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTIT FT HRIAHLVGAGHVATGQVLAVTFTQRAAAEMRSRLRALGAAVQAVSDFGVVRVLTFHAAA FT HRQLRYFWPRVIGDTGWQLLDSKFATVARAASSVRLHAGTDDVCDLAGEIEWAKASLIG FT PEEYVAAVAAIGRDTPLDAAQIASVYAAYEALKARGNGVPGVTLLDFDDLLLHTAAAIE FT NDAAVAEEFRDRYRCFVVDEYQDVTPLQQRVLSAWLGDRDDLTVVGDANQTIYSFTGAS FT PCFLLDFPRRFPDATVVRLERDYRSTPQVVSLANQVIAAAHGRVADSKFQLSGQREPGP FT AASFHEYSDEPAEAAAVAASIARLIEFGTSPSEIAVLYRVNAQSEAYEEALTEVGIAYQ FT VRGGEGFFNRQEIKQALLALQRSAERSSQTEPNSPLSDVVRGVLEPLGLTAEKPVGSRA FT RDRWEALTALAELADDEVAQHPRLDLPGLLAELRLRADARHPPVVQGVTLASLHAVKGL FT EWDAVFLVGLADGTLPISRALAHGAESEPVEEERRLLYVGITRARVYLALSWALSRTPG FT GRQSRKPSRFLNDIAPQMGQNPASSRSRRNRTATLRCRICKNDLTTPAAVMLQRCQICA FT ADVDEELLLQLKAWRLSTAKEQNVPAYVVLTDNTLIAIAELLPADEAALIAVPGMSVRK FT IEQYGSDVLQLVRCRAVAVRTQT" FT misc_feature 81163..82626 FT /note="Pfam match to entry PF00580 UvrD-helicase, UvrD/REP FT helicase, score 191.00, E-value 1.9e-53" FT misc_feature 81217..81240 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 83023..83268 FT /note="Pfam match to entry PF00570 HRDC, HRDC domain, score FT 54.00, E-value 3.4e-12" FT RBS 83412..83416 FT /note="possible RBS" FT CDS 83426..83728 FT /transl_table=11 FT /gene="ML0638" FT /product="putative secreted protein" FT /note="Unknown function. Previously sequenced as TR:Q49769 FT (EMBL:U00016) (100 aa); Fasta score E(): 0, 99.0% identity FT in 100 aa overlap. Contains a possible N-terminal signal FT sequence." FT /db_xref="GOA:Q49769" FT /db_xref="UniProtKB/Swiss-Prot:Q49769" FT /protein_id="CAC30147.1" FT /translation="MIDYNNVFGAGVVAAVSTAGTPHAATSAAAGQYRVAATGTRPWIG FT AILNYEVSPIFARWPRNRNHQDPWHSFWANSLPTWYRSFLKKDSHQTRKQMKRTC" FT RBS 83715..83720 FT /note="possible RBS" FT CDS 83722..83991 FT /transl_table=11 FT /gene="whiB7" FT /gene_synonym="ML0639" FT /product="putative transcriptional regulator" FT /note="Similar to M. tuberculosis Rv1021c, whiB7, probable FT DNA-binding protein, TR:Q9S4Q3 (EMBL:AF121014) (134 aa); FT Fasta score E(): 9.6e-25, 69.3% identity in 88 aa overlap FT (from mRNA). Shows weak similarity to members of the FT whiB-family of transcriptional regulators e.g. Streptomyces FT coelicolor whiD, WhiD protein, TR:O88103 (EMBL:AJ010601) FT (112 aa); Fasta score E(): 0.0045, 34.7% identity in 72 aa FT overlap. Previously sequenced as TR:Q49765 (EMBL:U00016) FT (89 aa); Fasta score E(): 0, 100.0% identity in 89 aa FT overlap." FT /note="Similar to ML0382, ML0760, ML0804 and ML2307" FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q49765" FT /protein_id="CAC30148.1" FT /translation="MLTLTIPKQTLPGLPCHADTSDLWFAETPADLECTKTLCANCPIR FT RPCLEAAMERAEPWGVWGGEIFDRGLIVSRKRPRGRPCNDVVVV" FT CDS complement(84068..85489) FT /transl_table=11 FT /gene="ML0640" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3197, putative ABC FT transporter, TR:O53343 (EMBL:AL123456) (447 aa); Fasta FT score E(): 0, 83.0% identity in 447 aa overlap. Similar to FT many ABC1-like hypothetical proteins from bacteria and FT eukaryotes. Similar to Saccharomyces cerevisiae ABC1, ABC1 FT protein precursor, SW:ABC1_YEAST (P27697) (501 aa); Fasta FT score E(): 7.3e-19, 24.9% identity in 382 aa overlap. FT Previously sequenced as TR:Q49747 (EMBL:U00016) (267 aa); FT Fasta score E(): 0, 99.6% identity in 248 aa overlap. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="Similar to ML1898" FT /db_xref="InterPro:IPR004147" FT /db_xref="UniProtKB/TrEMBL:Q9CCM8" FT /protein_id="CAC30149.1" FT /translation="MMRVKARMNNECSRLIIDCHITSMARFTVMDDRRVADIKRGQAAR FT NAKLASIPVGLAGRAVLGLGKRLTGKSKDEVNTKLIEKTAHQLFSVLGELKGGAMKVGQ FT ALSVMEAAIPEEYGEPYREALTKLQKDAPPLPVNKVHRVLDAQLGTKWRDRFSSFNDTP FT VASASIGQVHKAVWSYGREVAVKIQYPGADEALRADLKTMQRMVGILKQLSPGADIQGV FT VDELVERTEMELDYRLEADNQRAFAKAYQGDPRFVVPNVVASAPKVIIQEWIDGVPMAE FT IIRNGTAQQRDRMGKLLLELTFDSPRRLEMLHGDAHPGNFMLLSDGRMGVIDFGAIAPL FT PGGFPVELGMSIRLARDKNYNLLLQTMEKAGLIQKGRQVSVRDIDEMMHQYVEPIKVEV FT FHYTRKWLQQISLDRSVSHIKTARQLDLPATLALPMRVIASVGAILCQLDAHVPTKALT FT EKLVPGFAEPDTAIV" FT misc_feature complement(85274..85297) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(85607..86443) FT /pseudo FT /transl_table=11 FT /gene="ML0641" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3196 (Best blastx score 289)" FT CDS complement(86506..87945) FT /transl_table=11 FT /gene="ML0642" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3195, conserved FT hypothetical protein, TR:O53341 (EMBL:AL123456) (472 aa); FT Fasta score E(): 0, 79.2% identity in 475 aa overlap. FT Similar to Streptomyces coelicolor SCE9.14C, hypothetical FT protein, TR:Q9X8I7 (EMBL:AL049841) (375 aa); Fasta score FT E(): 4.9e-12, 24.9% identity in 305 aa overlap. previously FT sequenced as TR:Q49746 (EMBL:U00016) (479 aa); Fasta score FT E(): 0, 99.8% identity in 479 aa overlap." FT /db_xref="InterPro:IPR018766" FT /db_xref="UniProtKB/TrEMBL:Q49746" FT /protein_id="CAC30151.1" FT /translation="MAHSGSPVSTVDGVANPPFGFSSGNDSPNDESGRDKHGKNGPDSG FT SSGSDPLASFGMSGDFGMSDLGQIFTHLGQMFTNAGTAMTADKQLGPVNYELARRVASS FT SIGFVAPIPATTSSAIGDAVHLAETWLDGVTALPAGTTKAEGWTPDDWVNNTLETWKRL FT CDPMAQQISTVWAASLPEEAKSMASPLLSMMSQMGGMAFGSQLGQAFGQLSREVLTSTD FT IGLPLGPRGVAAIMPQAVESFADGLEQPRCEILTFLATREAAHHRLFSHVPWLASQLLG FT AVEAYAAGMKIDMNGIEELARDFNPASLSDPTAIEELLGQGVFEPQATPAQTQALERLE FT ALLALIEGWVQVVVTAALGDRIPGAAALGETLRRRRASGGPAEQTFATLVGLELRPRKL FT REAAVLWERLTQAAGVDARDAVWQHPDLLPSGKDLDDPASFIDRIIGGDTSGIDEAIAK FT LDLDRGNSDGRTPGSGGPVDN" FT CDS 88008..89030 FT /transl_table=11 FT /gene="ML0643" FT /product="putative secreted protein" FT /note="Similar to M. tuberculosis Rv3194c, conserved FT hypothetical protein, TR:O53340 (EMBL:AL123456) (340 aa); FT Fasta score E(): 0, 80.3% identity in 340 aa overlap. FT Similar to bacterial hypothetical proteins e.g. FT Streptomyces coelicolor sdrC, hypothetical protein, FT TR:Q9S3Y5 (EMBL:AF170560) (241 aa); Fasta score E(): FT 5.5e-18, 34.9% identity in 318 aa overlap. Contains a FT possible N-terminal signal sequence." FT /db_xref="GOA:Q9CCM7" FT /db_xref="HSSP:1RRE" FT /db_xref="InterPro:IPR001478" FT /db_xref="UniProtKB/TrEMBL:Q9CCM7" FT /protein_id="CAC30152.1" FT /translation="MNRRILTLLVALVPILVFGVLLAVVTVPFVSLGPGPTFDTLGEVD FT GKQVVAIKGAHTHPTSGHLNMTTVSQRDDLTLGEALTLWLSGQEQLVPRDLIYPPGKSR FT EDVDKVNYADFKQSEDSAAYAALGYLQYPSAVTVAKVTDPGQSVGKLKSGDAVDAVNGS FT PVANVEQFTGLLKKTKPGEVVTIDFRRKNEPPGVVQITLGANKDRDYGFLGVAVLDAPW FT APFVVDFNLANVGGPSAGLMFSLAVVDKLTTGDLVGSTFVAGTGTISIDGKVGPIGGIA FT HKMAAARAAGATVFLVPAKNCYEARSDNRTGLRLVKVESLSQAVDALHAMTSGGQLPSC FT " FT RBS 89164..89167 FT /note="possible RBS" FT CDS 89176..92127 FT /transl_table=11 FT /gene="ML0644" FT /product="putative integral membrane protein" FT /note="Similar to M. tuberculosis Rv3193c, putative FT integral membrane protein, TR:O53339 (EMBL:AL123456) (992 FT aa); Fasta score E(): 0, 86.1% identity in 989 aa overlap FT and to Rv0064, putative membrane protein, TR:O53609 FT (EMBL:AL123456) (979 aa); Fasta score E(): 0, 49.3% FT identity in 984 aa overlap. Similar to bacterial FT hypothetical membrane proteins. Previously sequenced as FT TR:O32904 (EMBL:Z98271) (277 aa); Fasta score E(): 0, FT 100.0% identity in 277 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions." FT /db_xref="GOA:Q9CCM6" FT /db_xref="InterPro:IPR005372" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCM6" FT /protein_id="CAC30153.1" FT /translation="MGMRPAARMPKLTRRSRTLIMVALGVIVLLLAGPRLVDAYVEWLW FT FGELGYRSVFSTVLVTRVVVFLVAGLVVGGIVFAGLAVAYRTRPVFVPSHDNDPVARYR FT AMALSRLRLIGVGIPAAIGLLAGIIAQSYWVRIQLFLHGDNFGIRDPQFGKDLGFYAFE FT LPFYRLVLSYVFVAVFLAFVVNLLAHYIFGGIRLSGRTGALSRLARLQLVSLVGVLVLL FT KAVAYWLDRYELLSRTRSSKPFTGAGYTDINAVQPAKLILIAIALICAAAVFSAITLRD FT FRIPAIGLVLLMLSSLIVGTGWPLIVEQLIAKPDAVRKESEYIRRSITATRHAYGLTED FT VVTYRNYIGDAPAIAQQIATDHATTSNIRLLDPTIVSPAFTQFQRGKNFYYFPDQLSID FT RYLDKKGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGFIASPANTVRGIANDP FT NQNGGYPQFLVNVVGNGTVVSEGPARLDQPRVYFGPVISNTSADYAIVGKNGDDREYDY FT ETNTDTKRYTYAGSGGVPIGSWLSRSVFAAKFAERNFLFSSVIGSNSKILFNRDPAQRV FT EAVAPWLTTDSSVYPAIVNKRLVWIIDGYTTLDNYPYSERTSLSSATADSTEVAFNRLA FT PDKRVAYIRNSVKATVDAYDGAVTLYQQDEYDPVLKVWMKVFPGTVRPKGDITPELAEH FT LRYPEDLFKVQRMLLAKYHVNDPGTFFNTSDFWDVPLDPNPTASSYQPPYYIVAKNILK FT NDRSASYQLTSAMNRFKQDFLAAYISASSDPETYGKITVLTIPGNVNGPKLANNAITTD FT PAVSQDLGVIGRDNQNRIRWGNLLTLPVAQGGLLYVEPVYASPGVSDAASSYPRLIRVA FT MMYNDKIGYGPTVGDALTGLFGPGAASAATGIEPTEAVPPKSPAGSSTPPIAVVPSAPD FT GSVALSAAKAAALQEIQAVIGAAREAQKKGDFVAYGSALQRLDDAITKFNSTK" FT tRNA 92284..92360 FT /gene="metU" FT /note="tRNA Met anticodon CAT, Cove score 88.77" FT CDS 94071..94519 FT /pseudo FT /transl_table=11 FT /gene="ML0645" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3172c (Best blastx score 176)" FT CDS 95177..95857 FT /pseudo FT /transl_table=11 FT /gene="hpx" FT /gene_synonym="ML0646" FT /product="probable non-heme haloperoxidase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT hpx (Best blastx score 187)" FT CDS complement(95902..97173) FT /pseudo FT /transl_table=11 FT /gene="ML0647" FT /product="Probable flavin-containing monoamine oxidase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3170 (Best blastx score 441)" FT CDS complement(98098..99165) FT /pseudo FT /transl_table=11 FT /gene="ML0648" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3169 (Best blastx score 168)" FT CDS complement(99162..100296) FT /pseudo FT /transl_table=11 FT /gene="ML0649" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3168 (Best blastx score 320)" FT CDS 100362..100662 FT /pseudo FT /transl_table=11 FT /gene="ML0650" FT /product="putative transcriptional regulator (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3167c (Best blastx score 210)" FT CDS complement(100694..101822) FT /pseudo FT /transl_table=11 FT /gene="ML0651" FT /product="REP-family protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT REP-family proteins (Best blastx score 93)" FT CDS 102108..103036 FT /pseudo FT /transl_table=11 FT /gene="ML0652" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3166c (Best blastx score 276)" FT CDS 103048..103528 FT /pseudo FT /transl_table=11 FT /gene="ML0653" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3165c (Best blastx score 151)" FT CDS 103657..104392 FT /pseudo FT /transl_table=11 FT /gene="moxR3" FT /gene_synonym="ML0654" FT /product="transcriptional regulator, MoxR homologue FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT moxR3 (Best blastx score 249)" FT CDS 104430..105542 FT /pseudo FT /transl_table=11 FT /gene="ML0655" FT /product="possible membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3163c (Best blastx score 376)" FT CDS complement(105592..105873) FT /transl_table=11 FT /gene="ML0656" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O32893 FT (EMBL:Z98271) (93 aa); Fasta score E(): 0, 100.0% identity FT in 93 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O32893" FT /protein_id="CAC30165.1" FT /translation="MTTANGVTTANRIYQIGRGEKSRWRSKLLRLTEHHDRVHKTIQQA FT LSPIDTWSLLPHNHGYCSSDSCHTLGVDSSQPHHQKTEISQQENNRGK" FT CDS complement(106101..106681) FT /pseudo FT /transl_table=11 FT /gene="nuoN" FT /gene_synonym="ML0657" FT /product="NADH dehydrogenase chain N (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT nuoN (Best blastx score 137)" FT CDS complement(106994..107483) FT /pseudo FT /transl_table=11 FT /gene="fadB4" FT /gene_synonym="ML0658" FT /product="3-hydroxyacyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadB4 (Best blastx score 267)" FT CDS complement(107537..107863) FT /transl_table=11 FT /gene="ML0659" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O32892 FT (EMBL:Z98271) (108 aa); Fasta score E(): 0, 100.0% identity FT in 108 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O32892" FT /protein_id="CAC30168.1" FT /translation="MVDTEVHNTQQHRESLNAIVWWLEKPGAGKLDGAKNDAGKRKKTL FT STKHSIPGRWPSAFGQFYPLVVRKDEDLLRRAVVRTSPTAFIFKRRKLLSLSLTTEVAC FT GRHE" FT RBS complement(107874..107877) FT /note="possible RBS" FT CDS complement(108047..109249) FT /transl_table=11 FT /gene="fadE23" FT /gene_synonym="ML0660" FT /product="putative acyl-CoA dehydrogenase" FT /note="Similar to M. tuberculosis fadE23, Rv3140, acyl-CoA FT dehydrogenase, TR:P95186 (EMBL:AL123456) (401 aa); Fasta FT score E(): 0, 89.5% identity in 401 aa overlap. Similar to FT many e.g. Homo sapiens acadS, acyl-coa dehydrogenase, FT short-chain specific precursor, SW:ACDS_HUMAN (P16219) (412 FT aa); Fasta score E(): 4.1e-31, 31.8% identity in 393 aa FT overlap. Previously sequenced as TR:O32891 (EMBL:Z98271) FT (400 aa); Fasta score E(): 0, 100.0% identity in 400 aa FT overlap. Contains 2 Pfam matches to entry PF00441 FT Acyl-CoA_dh, Acyl-CoA dehydrogenase." FT /note="Similar to ML0737" FT /db_xref="GOA:O32891" FT /db_xref="HSSP:3MDE" FT /db_xref="InterPro:IPR006091" FT /db_xref="UniProtKB/TrEMBL:O32891" FT /protein_id="CAC30169.1" FT /translation="MAINLELSRKLQAVIVKTHQGAAELMRPIARKYDLKEHTYPVELD FT TLFNLFAGAAESFAFAGADALGDEDNKDENHNGANMAALLQTLEACWGDVAMLLSIPYQ FT GLGNAAISAVATNKQLERLGKVWAAMAITEPGFGSDSAAVSTTATLDGDEYVINGEKIF FT VTAGSRATHIVVWATLDKSLGHAAIKSFIVPREHPGVTVERLEYKLGIRGSDTAAIRFD FT NVRIPKDNLLGNPEIEVGKGFSGVMETFDNTRPIVAAMAVGVGRAALEEIRKILTDAGI FT EICYDKPSHSQNAAAAEFLRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRM FT ASDVTLKAVELAGTAGYSEKALLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSEL FT K" FT misc_feature complement(108083..108349) FT /note="Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA FT dehydrogenase, score 65.60, E-value 2e-18" FT misc_feature complement(108437..108868) FT /note="Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA FT dehydrogenase, score 162.30, E-value 8.6e-47" FT CDS complement(109292..110689) FT /transl_table=11 FT /gene="fadE24" FT /gene_synonym="ML0661" FT /product="putative acyl-CoA dehydrogenase" FT /note="Similar to M. tuberculosis fadE24, Rv3139, acyl-CoA FT dehydrogenase, TR:P95187 (EMBL:AL123456) (468 aa); Fasta FT score E(): 0, 83.6% identity in 464 aa overlap. Similar to FT many e.g. Streptomyces lividans fadE, fatty acid acyl-CoA FT dehydrogenase, TR:Q9RIQ5 (EMBL:AJ250495) (385 aa); Fasta FT score E(): 5.1e-27, 28.5% identity in 376 aa overlap. FT Previously sequenced as TR:O32890 (EMBL:Z98271) (465 aa); FT Fasta score E(): 0, 100.0% identity in 465 aa overlap. FT Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, FT Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA FT dehydrogenases signature 2." FT /note="Similar to ML0737" FT /db_xref="GOA:O32890" FT /db_xref="HSSP:3MDE" FT /db_xref="InterPro:IPR006092" FT /db_xref="UniProtKB/TrEMBL:O32890" FT /protein_id="CAC30170.1" FT /translation="MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLV FT GQDFLDKYHLRYPLNRALRYGVKATFSTAAATSRQFKRVQNLRGGATRLQPSGRNYFDL FT TPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLGITTINIPEYFDGI FT AERRSSVTNVLVAEALAYGDMGLTLPILAPGGVAATLTYWGSADQQATYLKEFTGENVP FT QACVAIAEPQPLFDPTRLKTIAVRTPSGYRLDGVKSLVPAAASAELFIIGAQLNGKPAL FT FIVESSTKGLTVKADPSMGIRAAALGQVELCGVSAPLDARLGEDDATDNDYSEAIALAR FT LGWAALAVGTSHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRG FT ASRAEQGLSFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIKEHPVERWYRDLRAIGV FT AEGVVVI" FT misc_feature complement(109328..109672) FT /note="Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA FT dehydrogenase, score 116.20, E-value 2.9e-33" FT misc_feature complement(109334..109393) FT /note="PS00073 Acyl-CoA dehydrogenases signature 2" FT misc_feature complement(110216..110368) FT /note="Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA FT dehydrogenase, score 15.70, E-value 0.00088" FT CDS complement(110766..111533) FT /transl_table=11 FT /gene="ML0662" FT /product="putative monophosphatase" FT /note="Similar to M. tuberculosis Rv3137, putative FT monophosphatase, TR:P95189 (EMBL:AL123456) (260 aa); Fasta FT score E(): 0, 81.8% identity in 253 aa overlap. Similar to FT putative N-amidino-scyllo-inosamine-4-phosphate FT phosphatases from Streptomyces spp. e.g. Streptomyces FT glaucescens strO, TR:P72460 (EMBL:Y08764) (256 aa); Fasta FT score E(): 9.8e-19, 36.2% identity in 229 aa overlap. FT Previously sequenced as TR:O32889 (EMBL:Z98271) (255 aa); FT Fasta score E(): 0, 100.0% identity in 255 aa overlap. FT Contains 2 Pfam matches to entry PF00459 inositol_P, FT Inositol monophosphatase family. Contains PS00629 Inositol FT monophosphatase family signature 1." FT /note="Similar to ML1024" FT /db_xref="GOA:O32889" FT /db_xref="InterPro:IPR017955" FT /db_xref="UniProtKB/TrEMBL:O32889" FT /protein_id="CAC30171.1" FT /translation="MLALTLADRADALTSARFGALNLRVDTKPDLTPVTDADRAVEADV FT RAVLGRERPKDGILGEEYGGTITFSGQQWIVDPIDGTKNFVRGVPVWASLIALLEDGVP FT SIGVVSAPALQRRWWAARGQGAFVAVDGVPRRLAVSEVADLNSASLSFSSLSGWAQRGL FT RDRFLELTDAVWRVRAYGDFLSYCLLAEGAIDVAAEPKVSVWDLAALDIVVREAGGVLT FT GLDGTPGPHGGSAVATNGRLHQEVLTRIGATVK" FT misc_feature complement(110865..110984) FT /note="Pfam match to entry PF00459 inositol_P, Inositol FT monophosphatase family, score 24.20, E-value 8.5e-06" FT misc_feature complement(111150..111362) FT /note="Pfam match to entry PF00459 inositol_P, Inositol FT monophosphatase family, score 69.30, E-value 1.6e-18" FT misc_feature complement(111273..111314) FT /note="PS00629 Inositol monophosphatase family signature 1" FT CDS 111661..111975 FT /transl_table=11 FT /gene="ML0663" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O32888 FT (EMBL:Z98271) (104 aa); Fasta score E(): 0, 99.0% identity FT in 104 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O32888" FT /protein_id="CAC30172.1" FT /translation="MWEFGLLFLLVAILGVFLAKRFLPCESDLASGTLLVTGVSPRPDD FT AHGEQFVTIAGFISGPTVSEYSVYRRMVVDVGKWPAMGQLHPVVYSPKNPDNWKFALPD FT " FT CDS 112116..112379 FT /transl_table=11 FT /gene="ML0664" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCM5" FT /protein_id="CAC30173.1" FT /translation="MLPACSEEYPELTSIVKSIIDIQHDTCCGSLLSCNALTNLWSLIN FT RAVKTVVWNSEGMAGKDIDPRVKSALEVIKQNSGIVLSYSHQ" FT CDS 112705..113966 FT /pseudo FT /transl_table=11 FT /gene="ML0665" FT /product="Some similarity to D-lactate dehydrogenase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3107c (Best blastx score 234)" FT CDS complement(113976..115346) FT /transl_table=11 FT /gene="fprA" FT /gene_synonym="ML0666" FT /product="putative NADPH-ferredoxin reductase" FT /note="Similar to M. tuberculosis fprA, Rv3106, putative FT ferredoxin reductase, TR:O05783 (EMBL:AL123456) (456 aa); FT Fasta score E(): 0, 80.8% identity in 459 aa overlap. FT Similar to adrenodoxin reductases e.g. Bos taurus fdxR, FT NADPH:adrenodoxin oxidoreductase precursor, SW:ADRO_BOVIN FT (P08165) (492 aa); Fasta score E(): 0, 40.9% identity in FT 465 aa overlap. Previously sequenced as TR:O32886 FT (EMBL:Z98271) (456 aa); Fasta score E(): 0, 99.8% identity FT in 456 aa overlap." FT /note="Similar to ML2134" FT /db_xref="GOA:O32886" FT /db_xref="HSSP:1LQT" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/Swiss-Prot:O32886" FT /protein_id="CAC30175.1" FT /translation="MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEML FT PTPWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVIVGKHIEPAELAERYDAVI FT YAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFHERSPDLSGSRAVVIGNGNVAL FT DVTRILITDPDVLAFTDIADHALESLRPRGIEEVVIVGRRGPLQTAFTTLELRELADIE FT GVDVLVDPAQLEGISDENAAAAGKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEI FT KGKGKVERIVLGQNELVTDDNGRVAAKDTGVREELPAQLIVRSIGYRGVPTPGLPFDDS FT SVTIPNTNGRVNGSRNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLMENLAGANDTEKFG FT ADHADRLAEWLAERQPKLVTSAHWQAIDRFERAAGEPHGRPRVKLPNLAELLRIGHG" FT CDS 115526..116650 FT /transl_table=11 FT /gene="prfB" FT /gene_synonym="ML0667" FT /product="putative peptide chain release factor 2" FT /note="Similar to M. tuberculosis prfB, Rv3105c, peptide FT chain release factor 2, SW:RF2_MYCTU (O05782) (371 aa); FT Fasta score E(): 0, 90.1% identity in 372 aa overlap. FT Similar to many e.g. Streptomyces coelicolor prfB, peptide FT chain release factor 2, SW:RF2_STRCO (Q53915) (368 aa); FT Fasta score E(): 0, 66.9% identity in 369 aa overlap. FT Previously sequenced as SW:RF2_MYCLE (O32885) (374 aa); FT Fasta score E(): 0, 99.7% identity in 374 aa overlap. FT Contains Pfam match to entry PF00472 RF-1, Peptidyl-tRNA FT hydrolase domain. Contains PS00745 Prokaryotic-type class I FT peptide chain release factors signature." FT /note="Similar to ML1134" FT /db_xref="GOA:O32885" FT /db_xref="HSSP:1GQE" FT /db_xref="InterPro:IPR004374" FT /db_xref="UniProtKB/Swiss-Prot:O32885" FT /protein_id="CAC30176.1" FT /translation="MEPDRQTDIAALDSTLTTVERVLDVEGLRTRIEKLEHEASDPKLW FT DDQVRAQRVTSELSHAQGELRRIEELRRRLDDLPVLYELAAEERAAAAASGMEAFAEAD FT AELKALRVDIEATEVRTLLSGEYDEREALITIRSGAGGVDAADWAEMLMRMYIRWAEQH FT KYGVEVLDTSYAEEAGVKSATFAVHAPFAYGTLASEQGTHRLVRISPFDNQSRRQTSFA FT EVEVLPVVEITDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHVPTGLVVTCQNE FT KSQLQNKVSAMRVLQAKLLERKRLEERAELDALKGRGGSSWGNQIRSYVLHPYQMVKDL FT RNEYEVGNPTAVLDGDIDGFLEAGIRWRNRRDIS" FT misc_feature 116210..116548 FT /note="Pfam match to entry PF00472 RF-1, Peptidyl-tRNA FT hydrolase domain, score 216.20, E-value 4.8e-61" FT misc_feature 116270..116320 FT /note="PS00745 Prokaryotic-type class I peptide chain FT release factors signature" FT CDS 116680..117479 FT /pseudo FT /transl_table=11 FT /gene="ML0668" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3104c (Best blastx score 303)" FT CDS 117920..118609 FT /transl_table=11 FT /gene="ftsE" FT /gene_synonym="ML0669" FT /product="putative cell division ATP-binding protein" FT /note="Similar to M. tuberculosis ftsE, Rv3102c, cell FT division ATP-binding protein, TR:O05779 (EMBL:AL123456) FT (229 aa); Fasta score E(): 0, 91.7% identity in 229 aa FT overlap. Similar to many e.g. Escherichia coli ftsE, cell FT division ATP-binding protein, SW:FTSE_ECOLI (P10115) (222 FT aa); Fasta score E(): 0, 49.1% identity in 216 aa overlap. FT Previously sequenced as TR:O32883 (EMBL:Z98271) (229 aa); FT Fasta score E(): 0, 100.0% identity in 229 aa overlap. FT Contains Pfam match to entry PF00005 ABC_tran, ABC FT transporter. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00211 ABC transporters family FT signature." FT /db_xref="GOA:O32883" FT /db_xref="HSSP:1L2T" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:O32883" FT /protein_id="CAC30178.1" FT /translation="MITLDHVSKKYKSLARPALDNVNVKIDKGEFVFLIGPSGSGKSTF FT MRLLLGAETPTSGDVRVSKFHVNKLPGRHIPRLRQVIGCVFQDFRLLQQKTVYENVAFA FT LEVIGRRSDAINQVVPDVLETVGLSGKANRLPDELSGGEQQRVAIARAFVNRPLVLLAD FT EPTGNLDPDTSKDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVVELSLGRLVRDEWC FT GIYGMDR" FT misc_feature 118004..118561 FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 216.00, E-value 5.6e-61" FT misc_feature 118025..118048 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 118334..118378 FT /note="PS00211 ABC transporters family signature" FT CDS 118610..119503 FT /transl_table=11 FT /gene="ftsX" FT /gene_synonym="ML0670" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis ftsX, Rv3101c, cell FT division protein ftsX homolog, SW:FTSX_MYCTU (P96293) (297 FT aa); Fasta score E(): 0, 80.8% identity in 297 aa overlap. FT Similar to many ftsX homologues e.g. Bacillus subtilis FT ftsX, cell division protein ftsX homolog, SW:FTSX_BACSU FT (O34876) (296 aa); Fasta score E(): 2.5e-14, 25.8% identity FT in 302 aa overlap. Previously sequenced as SW:FTSX_MYCLE FT (O32882) (287 aa); Fasta score E(): 0, 99.7% identity in FT 287 aa overlap. Contains hydrophobic, possible FT membrane-spanning regions." FT /db_xref="GOA:O32882" FT /db_xref="InterPro:IPR003838" FT /db_xref="UniProtKB/Swiss-Prot:O32882" FT /protein_id="CAC30179.1" FT /translation="MRFGFLLNEVVTGLRRNVTMTIAMILTTAISIGLFGGGLLVVRLA FT DNSRSIYLDRVETQVFLTDDISANDLTCNTNLCKALRGKIEARDDVKSLRFLNRQDAYD FT DAIRKFPQYRDVAGKDSFPASFIIKLANPVQHKEFDAATQGQPGVLSVLNQKELIDRLF FT AVLDGLSDVAFVIALVQAIGAILLIANMVQVAAYTRRTEIGIMRLVGASRWYTQLPFLL FT EAMVAATVGAVIAIVGLLVARAMFLNNALNQFYQANLIARVDYADVLYVSPWLLLLGVA FT LAALTGYATLRIYVRR" FT CDS 119506..119988 FT /transl_table=11 FT /gene="smpB" FT /gene_synonym="ML0671" FT /product="putative SsrA-binding protein" FT /note="Similar to M. tuberculosis smpB, Rv3100c, FT SsrA-binding protein, SW:SMPB_MYCTU (P96294) (160 aa); FT Fasta score E(): 0, 84.9% identity in 159 aa overlap. FT Similar to many e.g. Escherichia coli smpB, SSRA-binding FT protein essential for the peptide-tagging activity of SsrA FT (tmRNA), SW:SMPB_ECOLI (P32052) (159 aa); Fasta score E(): FT 4.1e-19, 41.8% identity in 146 aa overlap. Previously FT sequenced as SW:SMPB_MYCLE (O32881) (160 aa); Fasta score FT E(): 0, 99.4% identity in 160 aa overlap. Contains Pfam FT match to entry PF01668 SmpB, SmpB protein. Contains PS01317 FT Protein smpB signature." FT /db_xref="GOA:O32881" FT /db_xref="HSSP:1P6V" FT /db_xref="InterPro:IPR020081" FT /db_xref="UniProtKB/Swiss-Prot:O32881" FT /protein_id="CAC30180.1" FT /translation="MARNPRGGKQIVATNRKARHDYAIIELFEAGVALLGTEVKSLREG FT HASLADAFATVDSGEVWLRNMHIPEYQHGSWTNHDPRRNRKLLLHRRQIDTLVGKIRDG FT NLALVPLSLYFAEGKVKVELALARGKKLHDKRQDMARRDAQREVIRELGRRAKGML" FT misc_feature 119539..119736 FT /note="Pfam match to entry PF01668 SmpB, SmpB protein, FT score 145.70, E-value 8.1e-40" FT misc_feature 119593..119631 FT /note="PS01317 Protein smpB signature" FT CDS 120148..120841 FT /pseudo FT /transl_table=11 FT /gene="ML0672" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3099c (Best blastx score 271)" FT misc_RNA 121055..121422 FT /gene="ssr" FT /note="tmRNA (10Sa RNA or SsrA) gene (see FT http://www.indiana.edu/~tmrna/)" FT CDS complement(121936..122483) FT /pseudo FT /transl_table=11 FT /gene="ML0673" FT /product="probable oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3359 (Best blastx score 307)" FT CDS 122692..123540 FT /transl_table=11 FT /gene="folD" FT /gene_synonym="ML0674" FT /product="putative methylenetetrahydrofolate FT dehydrogenase/methenyltetrahydrofolate cyclohydrolase" FT /EC_number="1.5.1.5" FT /EC_number="3.5.4.9" FT /note="Similar to M. tuberculosis folD, Rv3356c, putative FT methylenetetrahydrofolate dehydrogenase, TR:O50385 FT (EMBL:AL123456) (281 aa); Fasta score E(): 0, 86.5% FT identity in 281 aa overlap. Similar to many e.g. FT Escherichia coli folD, bifunctional FT methylenetetrahydrofolate dehydrogenase / FT methenyltetrahydrofolate cyclohydrolase, SW:FOLD_ECOLI FT (P24186) (287 aa); Fasta score E(): 0, 40.8% identity in FT 277 aa overlap. Previously sequenced as TR:O32879 FT (EMBL:Z98271) (282 aa); Fasta score E(): 0, 99.6% identity FT in 282 aa overlap. Contains Pfam match to entry PF00763 FT THF_DHG_CYH, Tetrahydrofolate FT dehydrogenase/cyclohydrolase." FT /db_xref="GOA:O32879" FT /db_xref="HSSP:1A4I" FT /db_xref="InterPro:IPR000672" FT /db_xref="UniProtKB/Swiss-Prot:O32879" FT /protein_id="CAC30183.1" FT /translation="MGAITLDGKATRDEILIDLKQRVAALTESGRTPGLGTILVGDDPG FT SHAYVRGKHADCAKVGITSIRRDLPVDITTAVLHDTIEELNANPDCTGYIVQLPLPKYL FT DENTALERVDPAKDADGLHPTNLGRLVLSTPAPLPCTARGILHLLRRYGVEIAGTHVVI FT IGRGVTVGRPLGLLLTRRSENATVTLCHTGTRNLAALTKQADIIVAAVGVPHLLTADMV FT RPGAVVVDVGVSRVETRLVGDVHPDVWEVAGHVSPNPGGVGPLTRVFLLTNVVELAEGR FT Q" FT misc_feature 122734..123525 FT /note="Pfam match to entry PF00763 THF_DHG_CYH, FT Tetrahydrofolate dehydrogenase/cyclohydrolase, score FT 547.30, E-value 1.1e-160" FT CDS 123543..123818 FT /transl_table=11 FT /gene="ML0675" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3346c, conserved FT hypothetical protein, TR:O50384 (EMBL:AL123456) (97 aa); FT Fasta score E(): 1.2e-24, 77.9% identity in 95 aa overlap FT (EMBL:AL123456) (97 aa); Fasta score E(): 1.2e-24, 77.9% FT identity in 95 aa overlap and Rv3355c, conserved FT hypothetical protein, TR:O50384. Previously sequenced as FT TR:O32878 (EMBL:Z98271) (91 aa); Fasta score E(): 0, 98.9% FT identity in 91 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O32878" FT /protein_id="CAC30184.1" FT /translation="MRAALRSQWPILLVGMIFAGAFVLVGANFWRRGALLIGIGVGVAT FT VLRLVLSDERAGLLMVRGKVIDLVTTALVGMAMVYIASTIDPLGTG" FT CDS complement(123815..124291) FT /transl_table=11 FT /gene="ML0676" FT /product="hypothetical protein" FT /note="Similar to M. tuberculosis Rv3354, conserved FT hypothetical protein, TR:O50383 (EMBL:AL123456) (129 aa); FT Fasta score E(): 6.2e-24, 55.9% identity in 127 aa overlap FT and Rv1690, hypothetical protein, TR:O33192 (EMBL:AL123456) FT (127 aa); Fasta score E(): 2e-09, 33.3% identity in 105 aa FT overlap. Previously sequenced as TR:O32877 (EMBL:Z98271) FT (168 aa); Fasta score E(): 0, 100.0% identity in 158 aa FT overlap." FT /db_xref="InterPro:IPR007969" FT /db_xref="UniProtKB/TrEMBL:Q9CCM4" FT /protein_id="CAC30185.1" FT /translation="MFLRLMLSALKALQRLGAVMNSLARIDHWIWLFRCQPLTIRLLVA FT TAALFTAATAFEVPAEADAIDDTFIKALNHAGVNFGEPRSAMTMGHYVCPILAKSGGNF FT AAAVQRIRGNSDMSPQMAETFAKIAISIYCPTMMANVASGNLPSLPPGPGIPGI" FT CDS 124527..125381 FT /pseudo FT /transl_table=11 FT /gene="ML0677" FT /product="probable oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0063 (Best blastx score 243)" FT CDS complement(125432..125959) FT /transl_table=11 FT /gene="ML0678" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O32876 FT (EMBL:Z98271) (175 aa); Fasta score E(): 0, 99.4% identity FT in 175 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O32876" FT /protein_id="CAC30187.1" FT /translation="MPISTPRPTRPEIIASTPGVRPVTYAVIAGPYRFHSLAAIWALSP FT NLSQSGQAEHQHELTNVGDPLLQETLFTAADQTRKTEQQLAGKYKLLITTERHHDSAIC FT QIAIILFIRIATCWRTDQHNIFRIVRMHYTVDKKTRINATAKRHSRCQKGRTDREQQKS FT PSTSIHQTVTPA" FT CDS 126145..126372 FT /transl_table=11 FT /gene="ML0679" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCM3" FT /protein_id="CAC30188.1" FT /translation="MTDQKRVRLGPHARDRIRLWGSGSGPAAPVWPYYSWIPAASYQPW FT PEQLELGVEALEDGVTALDDRGAGLDHPSQ" FT CDS 126992..128275 FT /pseudo FT /transl_table=11 FT /gene="ML0680" FT /product="REP-family protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT REP-family proteins (Best blastx score 392)" FT CDS complement(128353..129055) FT /pseudo FT /transl_table=11 FT /gene="ML0681" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3342 (Best blastx score 374)" FT CDS complement(129109..130257) FT /transl_table=11 FT /gene="metA" FT /gene_synonym="ML0682" FT /product="putative homoserine o-acetyltransferase" FT /note="Similar to M. tuberculosis metA, Rv3341, homoserine FT o-acetyltransferase, TR:O53391 (EMBL:AL123456) (379 aa); FT Fasta score E(): 0, 85.0% identity in 380 aa overlap. FT Similar to many e.g. Leptospira meyeri metX, homoserine FT o-acetyltransferase, TR:P94891 (EMBL:Y10744) (379 aa); FT Fasta score E(): 0, 36.4% identity in 382 aa overlap. FT Previously sequenced as TR:O32874 (EMBL:Z98271) (382 aa); FT Fasta score E(): 0, 100.0% identity in 382 aa overlap. FT Contains Pfam match to entry PF00561 abhydrolase, FT alpha/beta hydrolase fold." FT /db_xref="GOA:O32874" FT /db_xref="InterPro:IPR006296" FT /db_xref="UniProtKB/Swiss-Prot:O32874" FT /protein_id="CAC30191.1" FT /translation="MTISKVPTQKLPAEGEVGLVDIGSLTTESGAVIDDVCIAVQRWGE FT LSPTRDNVVMVLHALTGDSHITGPAGPGHPTPGWWDWIAGPGAPIDTNRWCAIATNVLG FT GCRGSTGPSSLARDGKPWGSRFPLISIRDQVEADIAALAAMGITKVAAVVGGSMGGARA FT LEWIIGHPDQVRAGLLLAVGVRATADQIGTQTTQIAAIKTDPNWQGGDYYETGRAPENG FT LTIARRFAHLTYRSEVELDTRFANNNQGNEDPATGGRYAVQSYLEHQGDKLLARFDAGS FT YVVLTETLNSHDVGRGRGGIGTALRGCPVPVVVGGITSDRLYPLRLQQELAEMLPGCTG FT LQVVDSTYGHDGFLVESEAVGKLIRQTLELADVGSKEDACSQ" FT misc_feature complement(129154..129972) FT /note="Pfam match to entry PF00561 abhydrolase, alpha/beta FT hydrolase fold, score 36.40, E-value 6.6e-07" FT CDS complement(130272..131512) FT /pseudo FT /transl_table=11 FT /gene="metC" FT /gene_synonym="ML0683" FT /product="cystathionine [beta]-lyase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT metC (Best blastx score 582)" FT CDS 131971..133100 FT /pseudo FT /transl_table=11 FT /gene="icd1" FT /gene_synonym="ML0684" FT /product="isocitrate dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT icd1 (Best blastx score 480)" FT CDS complement(133179..134090) FT /transl_table=11 FT /gene="ML0685" FT /product="putative hydrolase" FT /note="Similar to M. tuberculosis Rv3337, conserved FT hypothetical protein, TR:O53387 (EMBL:AL123456) (82 aa); FT Fasta score E(): 2.8e-17, 74.3% identity in 70 aa overlap FT and Rv3338, conserved hypothetical protein, TR:O53388 FT (EMBL:AL123456) (214 aa); Fasta score E(): 0, 65.9% FT identity in 214 aa overlap which are similar to the FT N-terminus and remainder respectively. Show weak similarity FT to various hydrolases e.g. Rhodococcus sp. etbD1, aromatic FT compound hydrolase, TR:O82828 (EMBL:AB004320) (274 aa); FT Fasta score E(): 1.8e-05, 25.8% identity in 267 aa overlap. FT Previously sequenced as TR:Q49926 (EMBL:U00022) (303 aa); FT Fasta score E(): 0, 99.7% identity in 303 aa overlap. FT Contains Pfam match to entry PF00561 abhydrolase, FT alpha/beta hydrolase fold." FT /db_xref="GOA:Q49926" FT /db_xref="InterPro:IPR000073" FT /db_xref="UniProtKB/TrEMBL:Q49926" FT /protein_id="CAC30194.1" FT /translation="MPACQHQRHRPVVACGTRGTTFRVGSMRQPIHLGSGEPVLLLHPF FT MMSQTVWEIVAPQLANTERYEVFAPTMAAHHGGPSASSWMMSVSTLADHVEQQLDELGW FT DTAHLVGNSLGGWVVFELERRGRARSVTGIAPAGGWTRWSLAKFEVIAKFVAGMPLVAV FT ARGLGSRALSLPFSHRLASLPLTGSPAGLSEHQLRNIVEDAGHCPAYFLLLIKTLLQPG FT LRELADITVPVLLVLCEKDRVLPPPKYSRHFTDHLPERTQVTKFDGMGHVPMFEAPEVI FT TKLITNFINQCSKPAEAASPAS" FT misc_feature complement(133224..133886) FT /note="Pfam match to entry PF00561 abhydrolase, alpha/beta FT hydrolase fold, score 38.00, E-value 2.1e-07" FT CDS 134126..135157 FT /transl_table=11 FT /gene="trpS" FT /gene_synonym="ML0686" FT /product="tryptophanyl tRNA synthetase" FT /EC_number="6.1.1.2" FT /note="Similar to M. tuberculosis trpS, Rv3336c, FT tryptophanyl-tRNA synthetase, SW:SYW_MYCTU (O53386) (336 FT aa); Fasta score E(): 0, 83.8% identity in 339 aa overlap. FT Similar to many e.g. Escherichia coli trpS, tryptophanyl FT tRNA synthetase, SW:SYW_ECOLI (P00954) (334 aa); Fasta FT score E(): 0, 49.6% identity in 335 aa overlap. Previously FT sequenced as SW:SYW_MYCLE (Q49901) (343 aa); Fasta score FT E(): 0, 100.0% identity in 343 aa overlap. Contains Pfam FT match to entry PF00579 tRNA-synt_1b, tRNA synthetases class FT I (W and Y). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00178 Aminoacyl-transfer RNA FT synthetases class-I signature." FT /db_xref="GOA:Q49901" FT /db_xref="HSSP:1MAU" FT /db_xref="InterPro:IPR002306" FT /db_xref="UniProtKB/Swiss-Prot:Q49901" FT /protein_id="CAC30195.1" FT /translation="MSTATGFSRIFSGVQPTSDSLHLGNALGAITQWVALQYDHPDEYE FT AFFCVVDLHAITIAQDPETLWRRTLVTAAQYLALGIDPGRAVVFVQSHVPAHTQLAWVL FT GCFTGFGQASRMTQFKDKALRQGADSTTVGLFTYPVLQAADVLAYDTDLVPVGEDQRQH FT LELARDLAQRFNSRFPDTFVVPDMFIPKMAAKIYDLADPTSKMSKSASSDAGLINLLDD FT PALSVKKIRAAVTDSEREIRYDPEVKPGVSNLLNIQSAVTGVDVDTLVQRYVGHGYGDL FT KKDTAEAVVEFVSPIKDRVDELMADLTELEVVLAVGAQRAQDVAGKTMQRVYDRLGFLP FT QRG" FT misc_feature 134153..134839 FT /note="Pfam match to entry PF00579 tRNA-synt_1b, tRNA FT synthetases class I (W and Y), score 334.40, E-value FT 1.3e-96" FT misc_feature 134171..134203 FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT misc_feature 135086..135109 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 135169..136110 FT /transl_table=11 FT /gene="ML0687" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3335c, conserved FT hypothetical protein, TR:O53385 (EMBL:AL123456) (289 aa); FT Fasta score E(): 0, 68.8% identity in 288 aa overlap. FT Similar to bacterial hypothetical proteins e.g. Escherichia FT coli yhjD, hypothetical protein, SW:YHJD_ECOLI (P37642) FT (337 aa); Fasta score E(): 5e-30, 34.9% identity in 278 aa FT overlap. Previously sequenced as TR:Q49909 (EMBL:U00022) FT (313 aa); Fasta score E(): 0, 100.0% identity in 313 aa FT overlap. Contains hydrophobic, possible membrane-spanning FT regions." FT /db_xref="GOA:Q49909" FT /db_xref="InterPro:IPR005274" FT /db_xref="UniProtKB/TrEMBL:Q49909" FT /protein_id="CAC30196.1" FT /translation="MTEPANTGIIDRLRGRFRWLDHVVRAHQRFDERNGSFFAAGLTYY FT TIFALFPMLMVSFSVVGLVLFRRPELLTTIDDHIRSAVSSQLGQELVDLMNRAIDARAS FT VGVVGLATAAWAGLCWMSHFRAALTKMWWEHHIDPSSLLRNKLSDLLAMVGTFVVFLTT FT LALTVLSHQAPMAAILRCIGITHFFVFGVIFQGASVLVSTLVSWLLFTWMIAWLPRKSV FT NLVASMRGGLIAAVGFELFKQVGSIYLQIVLRSPAGSVFGPVLGVMVFSYFTAYLVLFA FT ASWAATAELCMKPVSVQLPWSYLFPGRDESGS" FT CDS complement(136241..137376) FT /pseudo FT /transl_table=11 FT /gene="nagA" FT /gene_synonym="ML0688" FT /product="N-acetylglucosamine-6-P-deacetylase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT nagA (Best blastx score 253)" FT CDS complement(137391..138048) FT /pseudo FT /transl_table=11 FT /gene="ML0689" FT /product="glucosamine-fructose-6-phosphateaminotransferase( FT pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT glmS (Best blastx score 90)" FT CDS complement(138327..139763) FT /pseudo FT /transl_table=11 FT /gene="sugI" FT /gene_synonym="ML0690" FT /product="probable sugar transport protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT sugI (Best blastx score 360)" FT repeat_region 139601..139624 FT /note="24 bp direct repeat, Consensus, FT GATGCCGGAAAGGACCTAGTCTTA" FT repeat_region 139625..139648 FT /note="24 bp direct repeat, Consensus, FT GATGCCGGAAAGGACCTAGTCTTA" FT CDS complement(139877..141112) FT /transl_table=11 FT /gene="ML0691" FT /product="putative D-alanyl-D-alanine carboxypeptidase" FT /note="Similar to M. tuberculosis Rv3330, putative FT penicillin binding protein, TR:O53380 (EMBL:AL123456) (405 FT aa); Fasta score E(): 0, 77.2% identity in 416 aa overlap. FT Similar to PBP/D-alanyl-D-alanine carboxypeptidases e.g. FT Bacillus subtilis dacB, penicillin-binding protein 5* FT precursor, SW:DACB_BACSU (P35150) (382 aa); Fasta score FT E(): 2.2e-15, 31.3% identity in 243 aa overlap. Previously FT sequenced as TR:Q49917 (EMBL:U00022) (228 aa); Fasta score FT E(): 0, 100.0% identity in 228 aa overlap. Contains a FT probable N-terminal signal sequence. Contains Pfam match to FT entry PF00768 Peptidase_S11, D-alanyl-D-alanine FT carboxypeptidase." FT /db_xref="GOA:Q9CCM2" FT /db_xref="HSSP:1NZO" FT /db_xref="InterPro:IPR018044" FT /db_xref="UniProtKB/TrEMBL:Q9CCM2" FT /protein_id="CAC30200.1" FT /translation="MSFLRSTACLAAAVFAIVGPVALDLPTAVPVGHAEPNAGPNAGPA FT TCPYQVSTPPAVDSSEVPQTGNPPMPLAVPPKPVGGAALNSCGIVTAPDTPPVPGDLSA FT EAWLVADLNSGAVIAARDPHGRHRPASIIKVLLAMASINTLNLNKSVAGTAEDAAAEGT FT KVGVHDGGTYTINQLLHGLLMQSGNDAAHSLAMQLGGMQQALQKINVLAAKLGGQDTRV FT ATPSGLDGPGMSTSAYDIGLFYRYAWQNPSFSNIVATRTFNFPGPGDHPGYQLENDNQL FT LYQYPGALGGKTGYTDDAGQTFVGAANRNGRRLMAVLLHGTRQPIAPWEQAAHLLDYGF FT STAVGTQIGTLIEPDPTVAGNADRHGHGLQAAGIMSSNDTLPVRIGVAVVGTLIVFGLI FT MITRSLNRRPQH" FT misc_feature complement(140078..140842) FT /note="Pfam match to entry PF00768 Peptidase_S11, FT D-alanyl-D-alanine carboxypeptidase, score 179.80, E-value FT 4.3e-50" FT CDS complement(142042..143172) FT /pseudo FT /transl_table=11 FT /gene="ML0692" FT /product="probable aminotransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3329 (Best blastx score 840)" FT CDS 143183..143978 FT /pseudo FT /transl_table=11 FT /gene="sigJ" FT /gene_synonym="ML0693" FT /product="similar to SigI, ECF family (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT sigJ (Best blastx score 342)" FT CDS complement(144026..144536) FT /pseudo FT /transl_table=11 FT /gene="ML0694" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3327 (Best blastx score 175)" FT CDS 145165..145501 FT /pseudo FT /transl_table=11 FT /gene="ML0695" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT Rv2893 (Best blastx score 106)" FT CDS complement(145872..146666) FT /transl_table=11 FT /gene="sdhB" FT /gene_synonym="ML0696" FT /product="succinate dehydrogenase iron-sulfur protein" FT /EC_number="1.3.99.1" FT /note="Similar to M. tuberculosis sdhB, Rv3319, succinate FT dehydrogenase subunit B, TR:O53371 (EMBL:AL123456) (263 FT aa); Fasta score E(): 0, 89.8% identity in 264 aa overlap. FT Similar to many e.g. Escherichia coli sdhB, succinate FT dehydrogenase iron-sulfur protein, SW:DHSB_ECOLI (P07014) FT (238 aa); Fasta score E(): 0, 42.9% identity in 240 aa FT overlap. Previously sequenced as TR:Q49916 (EMBL:U00022) FT (264 aa); Fasta score E(): 0, 100.0% identity in 264 aa FT overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S FT iron-sulfur cluster binding domains. Contains PS00198 FT 4Fe-4S ferredoxins, iron-sulfur binding region signature." FT /db_xref="GOA:Q49916" FT /db_xref="HSSP:1NEK" FT /db_xref="InterPro:IPR004489" FT /db_xref="UniProtKB/TrEMBL:Q49916" FT /protein_id="CAC30205.1" FT /translation="MAVEPVEVKSLEPPRPPISDDAVMVTVKIARFNPDNPDAFAETGG FT WQSFRVPCLPTDRLLNLLIYIKGYLDGTLTFRRSCAHGVCGSDAMRVNGVNRLACKVLM FT RDLLPKKAGKNLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITSGNPPTRERIQ FT SPTDRARYDDTTKCILCACCTTSCPVFWSEGTYYGPAAIVNAHRFIFDSRDEGAGERLT FT LLNEVDGVWRCRTTFNCTESCPRNIEVTKAIQEVKRALMFSR" FT misc_feature complement(146103..146138) FT /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding FT region signature" FT misc_feature complement(146349..146516) FT /note="Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur FT cluster binding domains, score 5.80, E-value 1.8" FT CDS complement(146666..148420) FT /transl_table=11 FT /gene="sdhA" FT /gene_synonym="ML0697" FT /product="succinate dehydrogenase flavoprotein subunit" FT /EC_number="1.3.99.1" FT /note="Similar to M. tuberculosis sdhA, Rv3318, succinate FT dehydrogenase subunit A, TR:O53370 (EMBL:AL123456) (590 FT aa); Fasta score E(): 0, 92.5% identity in 590 aa overlap. FT Similar to many e.g. Escherichia coli sdhA, succinate FT dehydrogenase flavoprotein subunit, SW:DHSA_ECOLI (P10444) FT (588 aa); Fasta score E(): 0, 48.6% identity in 589 aa FT overlap. Previously sequenced as TR:Q49924 (EMBL:U00022) FT (401 aa); Fasta score E(): 0, 97.2% identity in 395 aa FT overlap. Contains Pfam match to entry PF00890 FT FAD_binding_2, FAD binding domain. Contains PS00504 FT Fumarate reductase / succinate dehydrogenase FAD-binding FT site." FT /db_xref="GOA:Q9CCM1" FT /db_xref="HSSP:1NEK" FT /db_xref="InterPro:IPR011281" FT /db_xref="UniProtKB/TrEMBL:Q9CCM1" FT /protein_id="CAC30206.1" FT /translation="MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTG FT AAQGGMCAALANVEDDNWEWHAFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPF FT NRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFY FT ALDLVLTQTPSGPVTTGVVAYELATGDIHVFHTKAVVIATGGSGRMYKTTSNAHTLTGD FT GIGIVFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNGENERFMEHYAPTI FT VDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGEEVLESKLPDITEFSRTYLGV FT DPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTN FT SLLDINVFGRRSGIAAASYASANDFVDMPPNPAEMVISWVANILSEHGNERVADIRGAL FT QQTMDNNAAVFRTEETLKQALTDIHSLKERYSRITVHDKGKSFNSDLLEAIELGFLLEL FT AEVTVVGALNRKESRGGHAREDYPHRDDTNYMRHTMAYKQGTDLLSDIALDFKPVVQTR FT YEPQERKY" FT misc_feature complement(147116..148105) FT /note="Pfam match to entry PF00890 FAD_binding_2, FAD FT binding domain, score 590.20, E-value 1.2e-173" FT misc_feature complement(148271..148300) FT /note="PS00504 Fumarate reductase / succinate dehydrogenase FT FAD-binding site" FT CDS complement(148441..148932) FT /transl_table=11 FT /gene="sdhD" FT /gene_synonym="ML0698" FT /product="putative succinate dehydrogenase hydrophobic FT membrane anchor protei" FT /note="Similar to M. tuberculosis sdhD, Rv3317, putative FT membrane anchor of succinate dehydrogenase, TR:O53369 FT (EMBL:AL123456) (144 aa); Fasta score E(): 0, 85.2% FT identity in 142 aa overlap. Shows weak similarity to e.g. FT Rickettsia prowazekii sdhD, succinate dehydrogenase FT hydrophobic membrane anchor protein, SW:DHSD_RICPR (P41086) FT (125 aa); Fasta score E(): 0.24, 26.7% identity in 105 aa FT overlap. Previously sequenced as TR:Q49915 (EMBL:U00022) FT (163 aa); Fasta score E(): 0, 100.0% identity in 163 aa FT overlap.Contains hydrophobic, possible membrane-spanning FT regions." FT /db_xref="UniProtKB/TrEMBL:Q49915" FT /protein_id="CAC30207.1" FT /translation="MSNSDLQLRPQVQPTCQKGQLAPVRQRSYDRPASLDNPRSPRRRA FT GIPNFEKFAWLFMRFSGVALVVLAFGHLFIMLMWDNGVYRIDFNFVAQRWSSPFWRFWD FT LALLWLAQVHGGNGLRNIIDDYSRKDHTRFWLNSLLLLSMGFTLVLGSYVLLSFDPNIS FT " FT CDS complement(148929..149390) FT /transl_table=11 FT /gene="sdhC" FT /gene_synonym="ML0699" FT /product="putative succinate dehydrogenase cytochrome B-556 FT subunit" FT /note="Similar to M. tuberculosis sdhC, Rv3316, putative FT membrane anchor of succinate dehydrogenase, TR:O53368 FT (EMBL:AL123456) (112 aa); Fasta score E(): 0, 88.4% FT identity in 112 aa overlap. Similar to many e.g. FT Escherichia coli sdhC, succinate dehydrogenase cytochrome FT B-556, SW:DHSC_ECOLI (P10446) (129 aa); Fasta score E(): FT 0.074, 24.3% identity in 136 aa overlap. Previously FT sequenced as TR:Q49919 (EMBL:U00022) (244 aa); Fasta score FT E(): 0, 100.0% identity in 153 aa overlap. Contains Pfam FT match to entry PF01127 Sdh_cyt, Succinate dehydrogenase FT cytochrome b subunit." FT /db_xref="GOA:Q9CCM0" FT /db_xref="InterPro:IPR014314" FT /db_xref="UniProtKB/TrEMBL:Q9CCM0" FT /protein_id="CAC30208.1" FT /translation="MRTTATPANPATSRPVAASSRRRRPPTTTYRGDPGMWSWVLHRIS FT GATIFFFLFVHVLDAAMLRVNPQTYNAVLSTYKAPIVGFMEYGLVAAVGFHGLNGIRVI FT LIDFWSEGPRHQRLMLWIISVIFLLLLVPAGVVIGIHMWEHFRMWEHFR" FT misc_feature complement(149001..149330) FT /note="Pfam match to entry PF01127 Sdh_cyt, Succinate FT dehydrogenase cytochrome b subunit, score -28.10, E-value FT 0.051" FT CDS 149679..150767 FT /transl_table=11 FT /gene="add" FT /gene_synonym="ML0700" FT /product="putative adenosine deaminase" FT /note="Similar to M. tuberculosis add, Rv3313c, probable FT adenosine deaminase, TR:O53365 (EMBL:AL123456) (365 aa); FT Fasta score E(): 0, 88.2% identity in 356 aa overlap. FT Similar to many e.g. Escherichia coli add, adenosine FT deaminase, SW:ADD_ECOLI (P22333) (333 aa); Fasta score E(): FT 6.8e-19, 29.7% identity in 340 aa overlap. Previously FT sequenced as TR:Q49907 (EMBL:U00022) (332 aa); Fasta score FT E(): 0, 99.7% identity in 332 aa overlap. Contains Pfam FT match to entry PF00962 A_deaminase, Adenosine/AMP FT deaminase." FT /db_xref="GOA:Q9CCL9" FT /db_xref="HSSP:1KRM" FT /db_xref="InterPro:IPR006330" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCL9" FT /protein_id="CAC30209.1" FT /translation="MNTPLHLENIKQAPKALLHDHLDGGLRPATVLDIAGQVGYDRLPA FT TDVESLETWFRTASHSGSLERYLEPFSHTVAVMQTPEALHRVAYECVEDLAADSVVYAE FT VRFAPELHIDEGLSFDEVLASVLAGFADGERACAAEGNAITVRCLVTAMRHAAMSREIA FT ELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAI FT AFCGADRLGHGVRIVDDIDVDPGGGIRLGPLASILRDKRIPLELCPSSNLQTGAVASIT FT EHPFDLLAWARFRVTVNTDNRLMSDTSMSLEMHRLVEAFGYGWGDLERFTINAMKSAFI FT PFDQRLAIIDEVIKPRFAVLVG" FT misc_feature 149691..150731 FT /note="Pfam match to entry PF00962 A_deaminase, FT Adenosine/AMP deaminase, score 395.60, E-value 4.8e-115" FT CDS 150834..151852 FT /pseudo FT /transl_table=11 FT /gene="ML0701" FT /product="possible membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis paralog FT Rv1481 (Best blastx score 222)" FT CDS complement(151856..152813) FT /pseudo FT /transl_table=11 FT /gene="ML0702" FT /product="possible membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis paralog FT Rv1481 (Best blastx score 92)" FT CDS complement(152882..154153) FT /transl_table=11 FT /gene="ML0703" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3311, conserved FT hypothetical protein, TR:O53362 (EMBL:AL123456) (420 aa); FT Fasta score E(): 0, 77.5% identity in 423 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCL8" FT /protein_id="CAC30212.1" FT /translation="MVADLVPICLSLPAGDRYTVWAPRWRDGGDEWEAFLGKDDNLYAC FT ETVADLVAFVRTDSDNDLVDHPAWKDLTSVHAHKLDPSEDNQFDLVVVEELVAEKPTAE FT SVTTLAATLAIVASIGSVCELPAVSKFFNGNPSLGAVSGGIEHFTGRAGQRRWNSIAEI FT IGRSWDDVLSAIDKVISTPRVNAAMSAKAADELAEEPVEPEVEPDDEDGADSATAQANN FT SDDTEDESRTAGDTVVLGSDKDFWLQVGIDPVRIMTGAGTFYTLRCYLDDHPIFLGRNG FT RISVFSSERALARYLADEHDHDLSYLSTYDDIRTAATDGSLAIDITDDNIYVLSGLSDD FT LADGPDAVDRDQLDLAVELLRDIGQYSEESAVDTALETNRPLGKLVAHVLSPSAVDKPV FT APYSAAVREWEKLEQFVESRLRLE" FT CDS complement(154232..155069) FT /pseudo FT /transl_table=11 FT /gene="ML0704" FT /product="probable acid phosphatase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3310 (Best blastx score 491)" FT CDS 155205..155831 FT /pseudo FT /transl_table=11 FT /gene="upp" FT /gene_synonym="ML0705" FT /product="uracil phophoribosyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT upp (Best blastx score 251)" FT CDS complement(155847..157463) FT /transl_table=11 FT /gene="pmmB" FT /gene_synonym="ML0706" FT /product="putative phospho-sugar mutase" FT /note="Similar to M. tuberculosis pmmB, putative FT phosphomannomutase, TR:O53360 (EMBL:AL123456) (534 aa); FT Fasta score E(): 0, 76.8% identity in 538 aa overlap. FT Similar to many putative phospho-sugar mutases and to FT Streptococcus pneumoniae pgm, phosphoglucomutase involved FT in type 3 capsule production and basic metabolism, FT TR:Q9RP94 (EMBL:AF165218) (572 aa); Fasta score E(): FT 1.4e-19, 32.6% identity in 549 aa overlap. Previously FT sequenced as TR:Q49913 (EMBL:U00022) (534 aa); Fasta score FT E(): 0, 99.8% identity in 534 aa overlap. Contains Pfam FT match to entry PF00408 PGM_PMM, FT Phosphoglucomutase/phosphomannomutase. Contains PS00710 FT Phosphoglucomutase and phosphomannomutase phosphoserine FT signature." FT /note="Shows weak similarity to ML0366 and ML0763" FT /db_xref="GOA:Q9CCL7" FT /db_xref="InterPro:IPR016066" FT /db_xref="UniProtKB/TrEMBL:Q9CCL7" FT /protein_id="CAC30215.1" FT /translation="MKAAVTPEEWITHDPDPQTAAELAACDPDELAARFTRALRFGTSG FT LRGPVRGGPDAMNLAVVLRATWAVAQVLLQRAGSRPATVIVGRDSRHGSAAFVAATAEV FT LAAEGFSVLLLPNPAPTPVVAFAVRNTGAAAGIQITASHNPPTDNGYKVYFDGGIQIIS FT PIDHQIENAMAAAPLADQITRKPVNPSENSASDLVDHYIQRAAAVRRSNGSVRVALTPM FT HGVGGAVAVETLRRTGFDDVHTVAAQFEPDPDFPTVAFPNPEEPGATDALLALAAHVGA FT DVAIALDPDADRCAVGIPTNSGWRMLSGDETGWLLGDYILSQTDKPETAVVASTVVSSR FT MLPAIATHYNAVHVETLTGFKWLARADANLPGTLVYAYEEAIGHCVDPTAVRDKDGISA FT AVLVCDLVAALHKQGRSVPDMLDQLALRHGVHDVTAISRRIGPKQTGVDEAVDLIQRLR FT AAPPSQLAGFTATTTDITDALIFTGGDDDTWVRVVVRLSGTEPKLKCYLEVRCSVAGNL FT PSTRQRARVLRDELVTLVQQW" FT misc_feature complement(155916..157355) FT /note="Pfam match to entry PF00408 PGM_PMM, FT Phosphoglucomutase/phosphomannomutase, score 109.30, FT E-value 7.4e-29" FT misc_feature complement(157014..157058) FT /note="PS00710 Phosphoglucomutase and phosphomannomutase FT phosphoserine signature" FT CDS complement(157460..158266) FT /transl_table=11 FT /gene="deoD" FT /gene_synonym="ML0707" FT /product="putative purine nucleoside phosphorylase" FT /EC_number="2.4.2.1" FT /note="Similar to M. tuberculosis deoD, Rv3307, probable FT purine nucleoside phosphorylase, SW:PUNA_MYCTU (O53359) FT (268 aa); Fasta score E(): 0, 82.1% identity in 262 aa FT overlap. Similar to many e.g. Bacillus stearothermophilus FT deoD, purine nucleoside phosphorylase I, SW:PUNA_BACST FT (P77834) (274 aa); Fasta score E(): 1.3e-16, 43.1% identity FT in 246 aa overlap. Previously sequenced as SW:PUNA_MYCLE FT (P46862) (268 aa); Fasta score E(): 0, 99.6% identity in FT 268 aa overlap. Contains Pfam match to entry PF00896 FT Mtap_PNP, phosphorylases family 2. Contains PS01240 Purine FT and other phosphorylases family 2 signature." FT /db_xref="GOA:P46862" FT /db_xref="HSSP:1G2O" FT /db_xref="InterPro:IPR011269" FT /db_xref="UniProtKB/Swiss-Prot:P46862" FT /protein_id="CAC30216.1" FT /translation="MTYTLLDPDELARRAAQVIGERTGILKHDVAVVLGSGWSSAVAAL FT GSSRAVFPQAELPGFITPNAAGHTGELLSVRIGAHRVLVLAGRIHPYEGHDLRHVVHPV FT RTACAAGARIIVLTNAAGGLRADMAVGQLVLISDHLNLTTRSPLVGTHFVDLTNAYTTR FT LRKLASDTDPTLTEGVYAAQPGPHYETPAEIRMLRMLGADLVGMSTVHETIAARAAGAE FT VLGVSLVTNLAAGITGKPLNHAEVLAAGTASANRIGSLLADIIARF" FT misc_feature complement(157574..158179) FT /note="Pfam match to entry PF00896 Mtap_PNP, phosphorylases FT family 2, score 357.90, E-value 1e-103" FT misc_feature complement(157895..158020) FT /note="PS01240 Purine and other phosphorylases family 2 FT signature" FT CDS 158400..159610 FT /pseudo FT /transl_table=11 FT /gene="amiB" FT /gene_synonym="ML0708" FT /product="probable aminohydrolase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT amiB (Best blastx score 355)" FT repeat_region 159093..159113 FT /note="21 bp direct repeat, Consensus, FT GTAATCCCGCGGACACGCGGC" FT repeat_region 159114..159134 FT /note="21 bp direct repeat, Consensus, FT GTAATCCCGCGGACACGCGGC" FT CDS 159645..160747 FT /pseudo FT /transl_table=11 FT /gene="amiA" FT /gene_synonym="ML0709" FT /product="probable aminohydrolase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT amiA (Best blastx score 489)" FT CDS 160943..161542 FT /pseudo FT /transl_table=11 FT /gene="ML0710" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis paralog FT Rv2248 (Best blastx score 255)" FT CDS complement(161828..162307) FT /transl_table=11 FT /gene="ML0711" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3304, conserved FT hypothetical protein, TR:O53356 (EMBL:AL123456) (159 aa); FT Fasta score E(): 0, 91.8% identity in 159 aa overlap. Shows FT weak similarity to Azotobacter vinelandii hypothetical FT protein, TR:Q44546 (EMBL:M23528) (183 aa); Fasta score E(): FT 1.3e-06, 30.1% identity in 146 aa overlap and Homo sapiens FT WUGSC:H_DJ0777O23.1, hypothetical protein, TR:O75223 FT (EMBL:AC005154) (188 aa); Fasta score E(): 4.9e-06, 26.8% FT identity in 149 aa overlap. Previously sequenced as FT TR:Q49927 (EMBL:U00022) (174 aa); Fasta score E(): 0, 98.7% FT identity in 149 aa overlap." FT /db_xref="InterPro:IPR017939" FT /db_xref="UniProtKB/TrEMBL:Q9CCL6" FT /protein_id="CAC30220.1" FT /translation="MPLYAAYGPNMHPEQMLKRAPHSPMAGTGWLPGWRLTFGGEDIGW FT EGALATVVEDPDSRVFVVLYDMTPADEMNLDRWEGSEFGVHKKIRCRVERESSDTTIDP FT VLAWLYVLDSWEGGLPSARYLGVMADAAEIAGAPNDYVHNLRTRPARNIGPGTTA" FT CDS 162436..163854 FT /pseudo FT /transl_table=11 FT /gene="lpdA" FT /gene_synonym="ML0712" FT /product="dihydrolipoamide dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lpdA (Best blastx score 410)" FT RBS 163933..163937 FT /note="possible RBS" FT CDS 163948..165705 FT /transl_table=11 FT /gene="glpD" FT /gene_synonym="ML0713" FT /product="putative glycerol-3-phosphate dehydrogenase" FT /note="Similar to M. tuberculosis glpD2, Rv3302c, FT glycerol-3-phosphate dehydrogenase, TR:O07168 FT (EMBL:AL123456) (585 aa); Fasta score E(): 0, 90.8% FT identity in 584 aa overlap. Similar to many e.g. FT Escherichia coli, glpD, glycerol-3-phosphate dehydrogenase, FT SW:GLPD_ECOLI (P13035) (501 aa); Fasta score E(): 0, 35.2% FT identity in 492 aa overlap. Also similar to Brucella FT abortus eriB, erythritol phosphate dehydrogenase, TR:Q9ZB31 FT (EMBL:U57100) (502 aa); Fasta score E(): 0, 35.4% identity FT in 483 aa overlap. Previously sequenced as SW:GLPD_MYCLE FT (P53435) (585 aa); Fasta score E(): 0, 99.8% identity in FT 585 aa overlap. Contains Pfam match to entry PF01224 FT FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate FT dehydrogenase. Contains PS00978 FAD-dependent FT glycerol-3-phosphate dehydrogenase signature 2. Contains FT PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase FT signature 1." FT /db_xref="GOA:P53435" FT /db_xref="InterPro:IPR006076" FT /db_xref="UniProtKB/Swiss-Prot:P53435" FT /protein_id="CAC30222.1" FT /translation="MTDLIQAPESEQTWPASALGPQQRAAAWERFGTEQFDVVVIGGGV FT VGSGCALDAATRGLKVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVREALYERE FT LSLTTLAPHLVKPLPFLFPLTKRWWERPYIAAGIFLYDRLGGAKSVPAQKHLTRAGALR FT LSPGLKRSSLIGGIRYYDTVVDDARHTLTVARTAAHYGAVVRCSTQVVALLREGDRVIG FT VRVRDSEDGAVTEIRGHVVVNATGVWTDEIQALSKQRGRFQVRVSKGVHVVVPRDRIVS FT DVAMILRTKKSVMFIIPWGNHWIIGTTDTDWNLDLAHPAATKADIDYILQTVNTVLATP FT LTHADIDGVYAGLRPLLAGESDDTSKLTREHAVAVPVAGLVAIAGGKYTTYRVMAADAI FT DAAVAFVPARVAPSITEKVGLLGADGYFALINQVEHVAALQGLHPYRVRHLLDRYGALI FT GDVLALAAEAPDLLSPIQEAPGYLKVEARYAVTAEGALHLEDILARRMRVSIEYPHRGV FT ACAREVADVVAPVLGWTAEDIDREVATYNARVEAEVLSQAQPDDVSADMLRASAPEART FT KIIEPVSLT" FT misc_feature 164044..165639 FT /note="Pfam match to entry PF01224 FAD_Gly3P_dh, FT FAD-dependent glycerol-3-phosphate dehydrogenase, score FT 994.40, E-value 2.7e-295" FT misc_feature 164068..164121 FT /note="PS00977 FAD-dependent glycerol-3-phosphate FT dehydrogenase signature 1" FT misc_feature 165100..165132 FT /note="PS00978 FAD-dependent glycerol-3-phosphate FT dehydrogenase signature 2" FT CDS 165693..166513 FT /pseudo FT /transl_table=11 FT /gene="ML0714" FT /product="probable deaminase, riboflavin synthesis FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3300c (Best blastx score 559)" FT CDS 166776..167690 FT /transl_table=11 FT /gene="lpqC" FT /gene_synonym="ML0715" FT /product="putative secreted hydrolase" FT /note="Similar to M. tuberculosis lpqC, Rv3298c, FT hypothetical protein, TR:P96903 (EMBL:AL123456) (304 aa); FT Fasta score E(): 0, 72.0% identity in 300 aa overlap. Shows FT weak similarity to hydrolases e.g. Piromyces equi estA, FT cinnamoyl ester hydrolase, TR:Q9Y871 (EMBL:AF164516) (536 FT aa); Fasta score E(): 4.8e-12, 27.9% identity in 265 aa FT overlap and Pseudomonas lemoignei phaZ1, secreted FT poly(3-hydroxyalkanoate) depolymerase C precursor, FT SW:PHA1_PSELE (P52090) (414 aa); Fasta score E(): 2.5e-06, FT 25.6% identity in 320 aa overlap. Previously sequenced as FT TR:Q49658 (EMBL:U00012) (302 aa); Fasta score E(): 0, 99.7% FT identity in 302 aa overlap. Contains a possible N-terminal FT signal sequence." FT /db_xref="GOA:Q9CCL5" FT /db_xref="InterPro:IPR017975" FT /db_xref="UniProtKB/TrEMBL:Q9CCL5" FT /protein_id="CAC30224.1" FT /translation="MNVARWLASVVLAVCLAGCVGRQVSASSRDQPGTFQFGGLNRTYV FT LHVPPGSPVGLVLNLHGGGGTGAGQQGLTDFDAVADLNNLLVAYPDGYDKSWADGRGAS FT PADRRHVDDVGFLVELAAKLQSDFGVAPGHVFVTGMSNGGFMSNKLACDRADMFAAIAP FT VAGTLGVDVACHPSQPVSVMDAHGTDDPLVPFNGGDVHGRGGVSHVVSVTNMVEKWRTA FT DGCQGDPSQQELPDVGDGTFVRRFDYTVCANSAEVVFYKINKGGHTWPGGKQYLPKVVI FT GSTTCVFDASEVIAQFFLTHARS" FT CDS complement(168124..171813) FT /pseudo FT /transl_table=11 FT /gene="lhr" FT /gene_synonym="ML0716" FT /product="ATP-dependent helicase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lhr (Best blastx score 824)" FT CDS complement(171917..172588) FT /transl_table=11 FT /gene="ML0717" FT /product="putative TetR-family transcriptional regulator" FT /note="Similar to M. tuberculosis Rv3295, putative FT TetR-family transcriptional regulator, TR:P96900 FT (EMBL:AL123456) (221 aa); Fasta score E(): 0, 85.5% FT identity in 220 aa overlap. Similar to many putative FT transcriptional regulators. Similar to Streptomyces tendae FT tarA, gamma-butyrolactone-binding protein, TR:Q9RPK9 FT (Expect = 5.0e-05). Previously sequenced as TR:Q49662 FT (EMBL:U00012) (242 aa); Fasta score E(): 0, 100.0% identity FT in 223 aa overlap. Contains a probable helix-turn-helix FT motif at aa 33-54 (Score 1535, SD +4.42) Contains Pfam FT match to entry PF00440 tetR, Bacterial regulatory proteins, FT tetR family." FT /db_xref="GOA:Q9CCL4" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q9CCL4" FT /protein_id="CAC30226.1" FT /translation="MTTARRRLSPEDRRAELLALGAEVFGKRPYDEVRIDEIAERAGVS FT RALMYHYFPDKRAFFAAVVKDEADRLYAATNIPPPAGLTMFEEVRVGVLAYMAYHKQNP FT EAAWAAYVGLGRSDPVLLGIDDEAKNRQMEHIMSRIGDVVSVVPESKLHPDIERDLRVI FT VHGWLAFTFEVCRQRIMDPSTDADRLADSCAHALLDAIARVPEISKELADAMAIARQPP FT Q" FT misc_feature complement(172400..172540) FT /note="Pfam match to entry PF00440 tetR, Bacterial FT regulatory proteins, tetR family, score 61.40, E-value FT 2e-14" FT CDS complement(172656..173952) FT /pseudo FT /transl_table=11 FT /gene="aldB" FT /gene_synonym="ML0718" FT /product="aldehyde dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT aldB (Best blastx score 421)" FT CDS complement(174129..175299) FT /pseudo FT /transl_table=11 FT /gene="ML0719" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3292 (Best blastx score 499)" FT CDS 175378..175778 FT /pseudo FT /transl_table=11 FT /gene="ML0720" FT /product="transcriptional regulator (Lrp/AsnC family) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3291c (Best blastx score 358)" FT CDS 175877..177225 FT /pseudo FT /transl_table=11 FT /gene="lat" FT /gene_synonym="ML0721" FT /product="lysine-[epsilon] aminotransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lat (Best blastx score 509)" FT CDS 177371..177700 FT /pseudo FT /transl_table=11 FT /gene="ML0722" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3289c (Best blastx score 261)" FT CDS 177725..178096 FT /pseudo FT /transl_table=11 FT /gene="ML0723" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3288c (Best blastx score 210)" FT CDS 178036..178821 FT /pseudo FT /transl_table=11 FT /gene="rsbW" FT /gene_synonym="ML0724" FT /product="anti-sigma B factor (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT rsbW (Best blastx score 286)" FT CDS 178917..179685 FT /pseudo FT /transl_table=11 FT /gene="sigF" FT /gene_synonym="ML0725" FT /product="ECF subfamily sigma subunit (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT sigF (Best blastx score 406)" FT CDS complement(179696..181492) FT /transl_table=11 FT /gene="bccA" FT /gene_synonym="ML0726" FT /product="acetyl/propionyl CoA carboxylase [alpha] subunit" FT /EC_number="6.3.4.14" FT /note="Similar to M. tuberculosis accA3, Rv3285, FT acetyl/propionyl CoA carboxylase [alpha] subunit, TR:P96890 FT (EMBL:AL123456) (600 aa); Fasta score E(): 0, 88.7% FT identity in 601 aa overlap. Previously sequenced as FT SW:BCCA_MYCLE (P46392) (598 aa); Fasta score E(): 0, 99.7% FT identity in 598 aa overlap. Contains Pfam match to entry FT PF00364 biotin_lipoyl, Biotin-requiring enzymes. Contains FT Pfam match to entry PF00289 CPSase_L_chain, FT Carbamoyl-phosphate synthase (CPSase). Contains PS00867 FT Carbamoyl-phosphate synthase subdomain signature 2. FT Contains PS00866 Carbamoyl-phosphate synthase subdomain FT signature 1. Contains PS00188 Biotin-requiring enzymes FT attachment site." FT /db_xref="GOA:P46392" FT /db_xref="HSSP:1BNC" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/Swiss-Prot:P46392" FT /protein_id="CAC30235.1" FT /translation="MASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAE FT APHVRLADEAFALGGHTSAESYLDFGKILDAAAKSGANAIHPGYGFLAENADFAQAVID FT AGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKNADEVVAFAKEHGVPIA FT IKAAFGGGGKGMKVARTLEEISELYESAVREATVAFGRGECFVERYLDKPRHVEAQVIA FT DQHGNIVVAGTRDCSLQRRFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTV FT EYLVGQDGLISFLEVNTRLQVEHPVTEETTGIDLVLQQFKIANGEKLELIKDPIPCGHA FT IEFRINGEDAGRNFLPSPGPVSKFHPPTGPGVRLDSGVETGSVIGGQFDSMLAKLIVHG FT ATRQEALARARRALDEFEVEGLATVIPFHRAVVSDPALIGDNNSFSVHTRWIETEWNNT FT IEPFIDNQPLDEEDTRPQQTVIVEVDGRRLEVSLPADLALANPAGCNPAGVIRKKPKPR FT KRGGHTGAATSGDAVTAPMQGTVVKVAVAEGQTVMTGDLVVVLEAMKMENPVTAHKDGI FT ITGLAVEAGTAITQGTVLAEIK" FT misc_feature complement(179702..179905) FT /note="Pfam match to entry PF00364 biotin_lipoyl, FT Biotin-requiring enzymes, score 88.00, E-value 1.9e-22" FT misc_feature complement(179780..179833) FT /note="PS00188 Biotin-requiring enzymes attachment site" FT misc_feature complement(180362..181462) FT /note="Pfam match to entry PF00289 CPSase_L_chain, FT Carbamoyl-phosphate synthase (CPSase), score 668.20, FT E-value 4.1e-197" FT misc_feature complement(180593..180616) FT /note="PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2" FT misc_feature complement(180971..181015) FT /note="PS00866 Carbamoyl-phosphate synthase subdomain FT signature 1" FT RBS complement(181497..181502) FT /note="possible RBS" FT CDS complement(181612..182011) FT /pseudo FT /transl_table=11 FT /gene="ML0727" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3284 (Best blastx score 203)" FT CDS complement(182028..182918) FT /transl_table=11 FT /gene="sseA" FT /gene_synonym="ML0728" FT /product="putative thiosulfate sulfurtransferase" FT /EC_number="2.8.1.1" FT /note="Similar to M. tuberculosis sseA, Rv3283, putative FT thiosulfate sulfurtransferase, SW:THT2_MYCTU (P96888) (297 FT aa); Fasta score E(): 0, 83.4% identity in 296 aa overlap. FT Similar to many e.g. Azotobacter vinelandii rhdA, FT thiosulfate sulfurtransferase, SW:THTR_AZOVI (P52197) (271 FT aa); Fasta score E(): 1.1e-18, 33.5% identity in 269 aa FT overlap. Previously sequenced as SW:THT2_MYCLE (P46700) FT (296 aa); Fasta score E(): 0, 99.7% identity in 296 aa FT overlap. Contains 2 Pfam matches to entry PF00581 FT Rhodanese, Rhodanese-like domain. Contains PS00380 FT Rhodanese signature 1. Contains PS00683 Rhodanese FT C-terminal signature." FT /note="Similar to ML2198" FT /db_xref="GOA:P46700" FT /db_xref="HSSP:1E0C" FT /db_xref="InterPro:IPR001307" FT /db_xref="UniProtKB/Swiss-Prot:P46700" FT /protein_id="CAC30237.1" FT /translation="MPLPTDPSPSLSAYAHPERLVTGDWLYFHLGKPGLAIVESDENVL FT LYDVGHIPGAVKVDWHTDLNDPKVRDYITGEQFADLMNRKGIARDDTVVIYGDKSNWWA FT AYALWVFTLFGHPDVRLLNGGRDLWLAERRDTSLAVPNKTSTSYPVVNRNDAPIRAFKD FT DVLAILGTQPLIDVRSLDEYTGKCTEMPDSPEESVLRAGHIPTARSIPWEMTVDKSGRF FT RSSEELERLYDFITPNDKTIVYCRIGERSSHTWFVLTHLLGKPGVRNYDGSWTEWGNTV FT RVPITAGESPGAVPV" FT misc_feature complement(182079..182438) FT /note="Pfam match to entry PF00581 Rhodanese, FT Rhodanese-like domain, score 108.90, E-value 9.9e-29" FT misc_feature complement(182088..182120) FT /note="PS00683 Rhodanese C-terminal signature" FT misc_feature complement(182523..182855) FT /note="Pfam match to entry PF00581 Rhodanese, FT Rhodanese-like domain, score 109.10, E-value 8.5e-29" FT misc_feature complement(182745..182780) FT /note="PS00380 Rhodanese signature 1" FT RBS complement(182934..182939) FT /note="possible RBS" FT CDS complement(183119..183760) FT /transl_table=11 FT /gene="ML0729" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3282, conserved FT hypothetical protein, TR:P96887 (EMBL:AL123456) (222 aa); FT Fasta score E(): 0, 68.5% identity in 213 aa overlap. FT Similar to maf-family proteins e.g. Bacillus subtilis maf, FT protein involved in septum formation, SW:MAF_BACSU (Q02169) FT (189 aa); Fasta score E(): 4.8e-08, 29.1% identity in 196 FT aa overlap. Also similar to the N-terminal half of Homo FT sapiens asmtl, acetylserotonin methytransferase-like gene, FT TR:O95671 (EMBL:Y15521) (629 aa); Fasta score E(): 2.1e-09, FT 31.6% identity in 193 aa overlap. Previously sequenced as FT TR:Q49670 (EMBL:U00012) (213 aa); Fasta score E(): 0, FT 100.0% identity in 213 aa overlap." FT /db_xref="GOA:Q49670" FT /db_xref="HSSP:1EX2" FT /db_xref="InterPro:IPR003697" FT /db_xref="UniProtKB/Swiss-Prot:Q49670" FT /protein_id="CAC30238.1" FT /translation="MTRLVLGSASAGRLKVLRQAGIDPLVAASGVDEDLVTAGLGSDTS FT PRDVVSTLARAKATQVAAALSHAVADDCVVISCDSQLSIDGRLYGKPQSVANARQQWQS FT MAGRAGQLYTGHCVIRLLNNETTYSVDETSMTTICFGNPSAEDLEAYLACGESLQVAGG FT FTLDGLGGWFIDAVYGDPSTVVGIGLPLTRSLLSRAGLSIAAMWAANPVI" FT CDS complement(183757..184011) FT /transl_table=11 FT /gene="ML0730" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 19.0 kda protein RV3281 OR MTCY71.21 TR:P96886 FT (EMBL:Z92771) fasta scores: E(): 2.4e-22, 69.0% id in 87 FT aa. Previously sequenced as TR:Q49671 (EMBL:U00012). FT Contains Pfam match to entry PF01039 Carboxyl_trans, FT Carboxyl transferase domain." FT /db_xref="UniProtKB/TrEMBL:Q49671" FT /protein_id="CAC30239.1" FT /translation="MSAANDGSETNKLPTTQNPHIQITKGQPTDQELAALIVVLSSIGG FT ASQVKQPEPTRWGLPVDKLRYPVFSWQRITLHEMTHMRR" FT CDS complement(184008..185657) FT /transl_table=11 FT /gene="accD5" FT /gene_synonym="ML0731" FT /product="acetyl/propionyl CoA carboxylase [beta] subunit" FT /EC_number="6.4.1.3" FT /note="Similar to Mycobacterium tuberculosis pccb PCCB OR FT RV3280 OR MTCY71.20 TR:P96885 (EMBL:Z92771) fasta scores: FT E(): 0, 88.7% id in 549 aa, and to Saccharopolyspora FT erythraea propionyl-CoA carboxylase beta chain PCCB FT SW:PCCB_SACER (P53003) fasta scores: E(): 0, 69.1% id in FT 530 aa. Previously sequenced as SW:PCCB_MYCLE (P53002). FT Contains Pfam match to entry PF01039 Carboxyl_trans, FT Carboxyl transferase domain." FT /note="Similar to ML0102 and ML1657" FT /db_xref="GOA:P53002" FT /db_xref="InterPro:IPR011762" FT /db_xref="UniProtKB/Swiss-Prot:P53002" FT /protein_id="CAC30240.1" FT /translation="MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGA FT AAFEKVHAKGKFTARERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVTGYGT FT IDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVS FT LGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVI FT KTVTGEDVTMEELGGAHTHMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYS FT KPVPHGSIEDNLTAKDLELDTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVV FT GLGRIDDRPVGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGT FT EQEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGCDVNLAWPTAQI FT AVMGASGAVGFVYRKELAQAAKNGANVDELRLQLQQEYEDTLVNPYIAAERGYVDAVIP FT PSHTRGYIATALHLLERKIAHLPPKKHGNIPL" FT misc_feature complement(184011..185555) FT /note="Pfam match to entry PF01039 Carboxyl_trans, Carboxyl FT transferase domain, score 915.00, E-value 2.1e-271" FT RBS 185710..185714 FT /note="possible RBS" FT CDS 185720..186544 FT /transl_table=11 FT /gene="birA" FT /gene_synonym="ML0732" FT /product="biotin apo-protein ligase" FT /note="Similar to Mycobacterium tuberculosis birA OR FT RV3279C OR MTCY71.19C TR:P96884 (EMBL:Z92771) fasta scores: FT E(): 0, 71.2% id in 271 aa, and to Escherichia coli birA FT bifunctional protein [includes: biotin operon repressor; FT biotin--[acetyl-coa-carboxylase] synthetase birA OR bioR OR FT dhbB SW:BIRA_ECOLI (P06709) fasta scores: E(): 2e-10, 31.3% FT id in 256 aa. Lacks the N-terminal helix-turn-helix domain, FT so may not act as a repressor. Contains Pfam match to entry FT PF01317 BPL, Biotin protein ligase." FT /db_xref="GOA:Q9CCL3" FT /db_xref="HSSP:1BIB" FT /db_xref="InterPro:IPR004408" FT /db_xref="UniProtKB/TrEMBL:Q9CCL3" FT /protein_id="CAC30241.1" FT /translation="MGSDLLKPPLDPAALRAELIGTGLRWRQLDVVTQTGSTNADLLAR FT AASGIDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSIGVSIADVPVATWAWLSLAT FT GVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGILAEVVRPVIVVGVGLNVT FT QAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRELDARVGQWRSADPQLMADYRARSPI FT IGSRVRAELPGGKDVVGTVRGIDDQGRLCLKTEGPTKGQTVVISAGDVVHLR" FT misc_feature 185792..186538 FT /note="Pfam match to entry PF01317 BPL, Biotin protein FT ligase, score 265.60, E-value 6.4e-76" FT CDS 186677..187195 FT /transl_table=11 FT /gene="ML0733" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 19.8 kda protein RV3278C OR MTCY71.18C TR:P96883 FT (EMBL:Z92771) fasta scores: E(): 0, 83.1% id in 172 aa. FT Previously sequenced as TR:Q49672 (EMBL:U00012). Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="InterPro:IPR005182" FT /db_xref="UniProtKB/TrEMBL:Q9CCL2" FT /protein_id="CAC30242.1" FT /translation="MRYPGNTLVAGEQVVLHRHPHWKRLIWPAVVLILATGLVSFGSGY FT VNSTHWAQVAKNVIYGVLWGVWLVIVGWLTLWPFLNWLTTHFVVTNRRVMFRQGTLTRS FT GVDIPLARINSVEFRDRLFERMFRTGTLIIESASQDPVEFYNIPRLRQMYALLYHEVFD FT TLGSEESPS" FT CDS complement(187150..187836) FT /transl_table=11 FT /gene="ML0734" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 30.1 kDa protein RV3277 OR MTCY71.17 TR:P96882 FT (EMBL:Z92771) fasta scores: E(): 0, 84.6% id in 228 aa. FT Previously sequenced as TR:Q49673 (EMBL:U00012). Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="GOA:Q49673" FT /db_xref="InterPro:IPR007267" FT /db_xref="UniProtKB/TrEMBL:Q49673" FT /protein_id="CAC30243.1" FT /translation="MSFPDATITRLPTVLQPYAQRYHELIKFAIVGGTTFIIDSAIFYT FT LKLTILEPKPVTAKVVAGIVAVIASYVLNREWSFRDRGGRERHNEALLFFAFSGIGVLL FT SMAPLWFSSYVLQLRAPTVSLTVENLADFLSAYIIGNLLQMAFRFWAFRRWVFPDAFAR FT NPEKTLESALTAGGIAEVFEDAIDGVFEDFGDALLRAWRNRSRRLDLSPASQLGDSSEP FT RVSKTS" FT stem_loop complement(187249..187308) FT /note="60 bp palindrome " FT CDS 187924..189243 FT /transl_table=11 FT /gene="purK" FT /gene_synonym="ML0735" FT /product="phosphoribosylaminoimidazole carboxylase ATPase" FT /EC_number="4.1.1.21" FT /note="Similar to Mycobacterium tuberculosis FT phosphoribosylaminoimidazole carboxylase atpase subunit FT purK OR RV3276C OR MTCY71.16C SW:PURK_MYCTU (P96881) fasta FT scores: E(): 0, 76.1% id in 444 aa, and to Corynebacterium FT ammoniagenes phosphoribosylaminoimidazole carboxylase FT ATPase subunit purK SW:PURK_CORAM (Q44678) fasta scores: FT E(): 0, 48.3% id in 404 aa. Previously sequenced as FT SW:PURK_MYCLE (P46701). Contains Pfam match to entry FT PF02222 ATP-grasp, ATP-grasp domain." FT /db_xref="GOA:P46701" FT /db_xref="HSSP:1B6R" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/Swiss-Prot:P46701" FT /protein_id="CAC30244.1" FT /translation="MMAVPSRCSLGVAPLVAMVGGGQLARMTHQAAIALGQTLRVLATA FT ADEPAAQVTPDVVIGSHTDLEDLRRVALGADALTFDHEHVPTELLDKLVAEGINVAPSP FT QALVHAQDKLVMRRRLAALGAAMPRFMALDSVDDLAEIDAFAQRLTGSKDAPMVVKAVR FT GGYDGRGVQMVRDSAHAREVASGYLVDGMPVLVEERVELRRELSALVARSPFGQGAAWP FT VVETVQRDGICVLVVAPALALADDLASAAQQLALRLAAELGVVGVFAVELFETADGALL FT VNELAMRPHNSGHWTMDGARTSQFEQHLRAVLDYPLGETDAVAPVTVMVNVLGAPQPPT FT LSVVTMDERLHHLFARMPDARVHLYDKVERPGRKVGHINFRGTDKDRKNPTKLRERAEL FT AAHWLSHGQWTDGWDPHRAGDDVVEISLACGGRNDAQRQR" FT misc_feature 188047..188556 FT /note="Pfam match to entry PF02222 ATP-grasp, ATP-grasp FT domain, score 145.20, E-value 1.2e-39" FT RBS 189230..189234 FT /note="possible RBS" FT CDS 189243..189758 FT /transl_table=11 FT /gene="purE" FT /gene_synonym="ML0736" FT /product="phosphoribosylaminoimidazole carboxylase" FT /EC_number="4.1.1.21" FT /note="Similar to Mycobacterium tuberculosis FT phosphoribosylaminoimidazole carboxylase catalytic subunit FT purE or Rv3275c or MTCY71.15C SW:PUR6_MYCTU (P96880) (174 FT aa) fasta scores: E(): 0, 81.5% id in 168 aa and to FT Corynebacterium ammoniagenes phosphoribosylaminoimidazole FT carboxylase catalytic subunit purE SW:PUR6_CORAM (Q44679) FT (177 aa) fasta scores: E(): 0, 66.2% id in 148 aa. FT Previously sequenced as SW:PUR6_MYCLE (P46702). Contains FT Pfam match to entry PF00731 AIRC, AIR carboxylase." FT /db_xref="GOA:P46702" FT /db_xref="HSSP:1O4V" FT /db_xref="InterPro:IPR000031" FT /db_xref="UniProtKB/Swiss-Prot:P46702" FT /protein_id="CAC30245.1" FT /translation="MTRQPRVGVIMGSDSDWSVMQDAAHALAEFDIPIEVRVVSAHRTP FT AEMFDYARNAVDRSIAVIIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGLDSLLSI FT VQMPAGVPVATVSIGGARNAGLLAVRILGSSDLQLRAQLVAFQDRLADTVRAKDADLQR FT FRGKLIGD" FT misc_feature 189258..189701 FT /note="Pfam match to entry PF00731 AIRC, AIR carboxylase, FT score 322.30, E-value 5.6e-93" FT RBS 189842..189847 FT /note="possible RBS" FT CDS 189853..191022 FT /transl_table=11 FT /gene="fadE25" FT /gene_synonym="ML0737" FT /product="putative acyl-CoA dehydrogenase" FT /note="Similar to Mycobacterium tuberculosis RV3274C OR FT MTCY71.14C, putative acyl-CoA dehydrogenase, TR:P96879 FT (EMBL:Z92771) fasta scores: E(): 0, 92.0% id in 389 aa, and FT to Streptomyces lividans fatty acid acyl-CoA dehydrogenase FT fadE TR:Q9RIQ5 (EMBL:AJ250495) fasta scores: E(): 0, 67.6% FT id in 383 aa. Previously sequenced as SW:ACD_MYCLE FT (P46703). Contains Pfam match to entry PF00441 Acyl-CoA_dh, FT Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA FT dehydrogenases signature 2. Contains PS00072 Acyl-CoA FT dehydrogenases signature 1." FT /note="Similar to ML0660, ML0661 and shows weaker FT similarity to ML2563" FT /db_xref="GOA:P46703" FT /db_xref="HSSP:1JQI" FT /db_xref="InterPro:IPR013764" FT /db_xref="UniProtKB/Swiss-Prot:P46703" FT /protein_id="CAC30246.1" FT /translation="MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRA FT RFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGT FT MGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFK FT CWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELY FT FDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFG FT ESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEV FT TTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR" FT misc_feature 189895..191007 FT /note="Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA FT dehydrogenase, score 798.10, E-value 3.4e-236" FT misc_feature 190249..190287 FT /note="PS00072 Acyl-CoA dehydrogenases signature 1" FT misc_feature 190888..190947 FT /note="PS00073 Acyl-CoA dehydrogenases signature 2" FT CDS complement(191312..191458) FT /pseudo FT /transl_table=11 FT /gene="pstA2" FT /gene_synonym="ML0738" FT /product="PstA component of phosphate uptake (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pstA2 (Best blastx score 95)" FT CDS complement(191534..192518) FT /pseudo FT /transl_table=11 FT /gene="pstC" FT /gene_synonym="ML0739" FT /product="PstC component of phosphate uptake (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pstC (Best blastx score 346)" FT CDS complement(193071..193654) FT /pseudo FT /transl_table=11 FT /gene="phoS1" FT /gene_synonym="ML0740" FT /product="PstS component of phosphate uptake (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT phoS1 (Best blastx score 238)" FT CDS complement(193783..194588) FT /pseudo FT /transl_table=11 FT /gene="pstB" FT /gene_synonym="ML0741" FT /product="ABC transport component of phosphate uptake FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pstB (Best blastx score 307)" FT CDS 194887..195982 FT /pseudo FT /transl_table=11 FT /gene="pstS" FT /gene_synonym="ML0742" FT /product="PstS component of phosphate uptake (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pstS (Best blastx score 440)" FT CDS 196241..197771 FT /pseudo FT /transl_table=11 FT /gene="pknD" FT /gene_synonym="ML0743" FT /product="serine-threonine protein kinase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pknD (Best blastx score 458)" FT CDS complement(197848..198981) FT /pseudo FT /transl_table=11 FT /gene="ML0744" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3272 (Best blastx score 782)" FT CDS complement(199113..199966) FT /pseudo FT /transl_table=11 FT /gene="ML0745" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv1729c (Best blastx score 318)" FT CDS 200118..200693 FT /pseudo FT /transl_table=11 FT /gene="ML0746" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3271c (Best blastx score 151)" FT CDS complement(200793..202970) FT /transl_table=11 FT /gene="ctpC" FT /gene_synonym="ML0747" FT /product="putative cation transport ATPase" FT /note="Similar to Mycobacterium tuberculosis probable FT cation-transporting p-type ATPase C ctpC OR RV3270 OR FT MTCY71.10 SW:CTPC_MYCTU (P96875) fasta scores: E(): 0, FT 86.0% id in 713 aa, and to Mycobacterium tuberculosis metal FT transporting atpase mta72 mtaA TR:O66027 (EMBL:U82820) FT fasta scores: E(): 0, 79.4% id in 688 aa. Contains FT hydrophobic, possible membrane-spanning region. Contains 2 FT Pfam matches to entry PF00122 E1-E2_ATPase, E1-E2 ATPase. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT Contains PS00154 E1-E2 ATPases phosphorylation site. FT Contains PS01229 Hypothetical cof family signature 2." FT /db_xref="GOA:Q9CCL1" FT /db_xref="InterPro:IPR018303" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCL1" FT /protein_id="CAC30256.1" FT /translation="MTLAMAEQIATADNPAFVVVSDAAGRMRIQIEWVRSNPRRAVTVE FT EAIAKCNGVRVVHAYPRTGSVVVWYSPRCCDRQSILAAISGAAHVAAELIPTRAPHSSD FT IRNIEVLRMAIGAAALTLLGVRRYVFARPLLLPTTSRLVASGVTIFTGYPFLRGALRFG FT KTGTDALVSVATIASLILRENVVALAVLWLLNIGEYLQDLTLRRTRRAISALLSGTQDT FT AWIRLTDGPQAGTEIQVPIGTVQIGDEVVVHEHVAIPVDGEVIDGEAVVNQSAITGENL FT PVSVMAGSHVHAGSVVVRGRLMVRASAVGKHTTIGRIVTRVEEAQHDRAPIQTVGENFS FT RCFVPTSFVVSAITLAITKDVRRTMTVLLIACPCAVGLATPTAISAAIGNGARRGILIK FT GGSHLEQAGRVDAILFDKTGTLTVGRPVVTNIVAMHKDWSPEQVLAYAASSEIHSRHPL FT AEAVIRSTEERHISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLCAEKVKVSKTASE FT WVDKLRHQTETPLLFAVDGTLVGLISLRDEVRPEAAEVLTKLRASGVRRIVMLTGDHPD FT IAKAVATELGIDEWRAEVMPEDKLKVVRDLQNEGYVVGMVGDGVNDAPALAAADIGIAM FT GLAGTDVAVETADVALANDDLNRLLDVRDLGGRAVEVIRENYGMSIAVNAAGLFIGAGG FT ALSPVLAAVLHNASSVAVVANSSRLIRYRLD" FT misc_feature complement(200823..201374) FT /note="Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 FT ATPase, score 216.20, E-value 4.9e-61" FT misc_feature complement(201057..201125) FT /note="PS01229 Hypothetical cof family signature 2" FT misc_feature complement(201552..202406) FT /note="Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 FT ATPase, score 246.10, E-value 4.7e-70" FT misc_feature complement(201705..201725) FT /note="PS00154 E1-E2 ATPases phosphorylation site" FT misc_feature complement(202476..202499) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(202981..203259) FT /transl_table=11 FT /gene="ML0748" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 9.8 kDa protein irpA OR RV3269 OR MTCY71.09 TR:P96874 FT (EMBL:Z92771) fasta scores: E(): 5.5e-23, 73.6% id in 91 FT aa, to Mycobacterium tuberculosis hypothetical 9.4 kDa FT protein RV1993C OR MTCY39.26 SW:YJ93_MYCTU (Q10865) fasta FT scores: E(): 6.3e-14, 60.8% id in 79 aa and to FT Mycobacterium tuberculosis hypothetical 10.3 kDa protein FT RV0968 OR MTCY10D7.06C SW:Y968_MYCTU (P71542) fasta scores: FT E(): 4.4e-11, 52.1% id in 96 aa." FT /db_xref="InterPro:IPR009963" FT /db_xref="UniProtKB/TrEMBL:Q9CCL0" FT /protein_id="CAC30257.1" FT /translation="MVQGLLAKAATMVITGLTGVTAYEMLRKAVTKVPLHQIAVSALEL FT GLRGSRKAEEAAESARLKLADVMAEARERIGKETTAPAVSDIHQHDH" FT CDS complement(203408..204024) FT /pseudo FT /transl_table=11 FT /gene="ML0749" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3268 (Best blastx score 385)" FT CDS complement(204063..205532) FT /transl_table=11 FT /gene="ML0750" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 51.3 kDa protein RV3267 OR MTCY71.07 TR:P96872 FT (EMBL:Z92771) fasta scores: E(): 0, 78.9% id in 498 aa, and FT to Mycobacterium tuberculosis cpsA OR RV3484 OR FT MTCY13E12.37 TR:O06347 (EMBL:Z95390) fasta scores: E(): 0, FT 34.5% id in 502 aa. Also similar to hypothetical proteins FT from capsular polysaccharide biosynthesis loci (homologues FT of Streptococcus agalactiae cpsX, which may have a FT regulatory function) and to frnA from a Streptomyces FT roseofulvus polyketide biosynthesis locus." FT /note="Similar to ML2247" FT /db_xref="InterPro:IPR004474" FT /db_xref="UniProtKB/TrEMBL:Q9CCK9" FT /protein_id="CAC30259.1" FT /translation="MPVQRVVRAVVTALTLAIVLGTGITWTSFRSFEDGIFHMSAPSLG FT KGGNDGAIDILLVGLDSRTDAYGNPLSAEELATLRAGDEEATNTDTIILIRIPNNGKSA FT TAISIPRDSYVQAPGLGKAKINGVYGQTREAKRASLVRTGDSAEDAAAQGTEAGREALI FT KTVADLTGVTVDHYAEIGLLGFALIVDALGGVDVCLKDAVFEPMSGADFPAGRQKLNGP FT QALSFVRQRHELPRGDLDRVVRQQAVMASLVHRVISGQTLSNPSTIKHLEQAIQRSVVI FT SSGWNLMDFLKQLQSLADRKVAFATIPVLDETGWSDDGMQSVVRVDPHQVQNFVSGLLH FT NQAQDKTDELAYTPAKITANVANDTDINGLAAAVSDILTTKGFIAGSVANNQGSHVKSS FT QVRAAKSDDLGAQKVSKELGGLPIVVDGSIPAGSVLVILANDYTGPGSGLFGNGSIASD FT YASNPGASADPNIPVPSPILTAGSDQPECIN" FT CDS 205621..206556 FT /transl_table=11 FT /gene="rmlD" FT /gene_synonym="ML0751" FT /product="putative dTDP-rhamnose modification protein" FT /note="Similar to Mycobacterium tuberculosis rfbD OR FT RV3266C OR MTCY71.06C TR:P96871 (EMBL:Z92771) fasta scores: FT E(): 0, 74.4% id in 312 aa, to Saccharopolyspora erythraea FT thymidine diphospho-4-keto-6-deoxyglucose 3, 5-epimerase FT kde TR:Q54117 (EMBL:L37354) fasta scores: E(): 0, 49.2% id FT in 301 aa and to Streptomyces griseus FT dTDP-4-dehydrorhamnose reductase strL SW:STRL_STRGR FT (P29781) fasta scores: E(): 1.6e-32, 44.4% id in 311 aa." FT /db_xref="GOA:Q9CCK8" FT /db_xref="HSSP:1N2S" FT /db_xref="InterPro:IPR005913" FT /db_xref="UniProtKB/TrEMBL:Q9CCK8" FT /protein_id="CAC30260.1" FT /translation="MSDRSGRLVITGAGGQLGSALAAQATAAGRDVLALTSSQWDITDA FT AVAERMGRSALKKNDVVVNCAAYTNVDGAESNELAAYAVNATGPEYIARACRCAGAALI FT HVSTDYVFSGDFGSGANRVAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPEATVVRT FT AWVYTGGTGKDFVAVMRRLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVADGSVHGSVL FT HAANEGEVSRFGQARAVFEECGADPLQVQPVSTAQNPRSAARPAYSALSGRQSVAAGLT FT PLRPWRSALVEALAVSRSLPVDRPLPSTRD" FT CDS 206549..207475 FT /transl_table=11 FT /gene="wbbL" FT /gene_synonym="ML0752" FT /product="putative dTDP-rhamnosyl transferase" FT /note="Similar to Mycobacterium tuberculosis putative FT dTDP-rhamnosyl transferase RV3265C OR MTCY71.05C TR:P96870 FT (EMBL:Z92771) fasta scores: E(): 0, 84.7% id in 301 aa, and FT to Mycobacterium smegmatis dTDP-rha:A-D-GlcNAc-diphosphoryl FT polyprenol, A-3-L-rhamnosyl transferase wbbL TR:Q9RN50 FT (EMBL:AF187550) fasta scores: E(): 0, 69.9% id in 296 aa. FT Contains Pfam match to entry PF00535 Glycos_transf_2, FT Glycosyl transferases." FT /db_xref="GOA:Q9CCK7" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q9CCK7" FT /protein_id="CAC30261.1" FT /translation="MTDVLPVVAVTYSPGPHLERFLASLALATDRPVSVVLADNGSTDG FT TPQVAVERYVNVRLFETGANLGYGTAANLAIAQFFEEGGATGQPWVDDWVIVANPDVQW FT GPGSIDALLDAAARWPRAGALGPLIRDPDGSVYPSARHLPSLVRGGMHAVLGPVWPRNP FT WTAAYRQERLELTERPVGWLSGSCLLVRRSAFREVGGFDERYFMYMEDVDLGDRLGKAG FT WLSVYVPSAEVLHHKGHSTGRDPVSHLAAHHKSTYIFLADRHSGWWRAPLRWMLRGSLV FT VRSRLMVRSSRRKQAAKQARQLAEGRR" FT misc_feature 206564..207076 FT /note="Pfam match to entry PF00535 Glycos_transf_2, FT Glycosyl transferases, score 21.90, E-value 0.0029" FT CDS 207477..208553 FT /transl_table=11 FT /gene="rmlA2" FT /gene_synonym="ML0753" FT /product="putative sugar-phosphate nucleotidyl transferase" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT protein RV3264C OR MTCY71.04C TR:P96869 (EMBL:Z92771) fasta FT scores: E(): 0, 86.9% id in 359 aa. Similar to FT Saccharomyces cerevisiae mpg1, mannose-1-phosphate FT guanyltransferase SW:MPG1_YEAST (P41940) blastp score: FT 141.5 bits, 29% identity in 349 aa. Contains Pfam match to FT entry PF00483 NTP_transferase, Nucleotidyl transferase. FT Contains 3 Pfam matches to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats)." FT /note="ML2503" FT /db_xref="GOA:Q9CCK6" FT /db_xref="InterPro:IPR001451" FT /db_xref="UniProtKB/TrEMBL:Q9CCK6" FT /protein_id="CAC30262.1" FT /translation="MATLQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSR FT IAAAGIEHVILSTSYRDAVFEAEFGDGSKLGLQIDYVIEESPLGTGGGIANVIDQLRHD FT TVMVFNGDVLSGVDLGQLLGFQRTNFADVTLHLVRVGDPRAFGCVSTEDGRVTAFLEKT FT QDPPTDQINAGCYVFERNVIDRIPRGREVSVEREVFPTLLSDADVKVCGYVDATYWRDM FT GTPEDFVRGSADLVRGIAPSPALGGHRGEHLVHDGAAVSPGAVLIGGTVVGRGAEIGPG FT VRLDGAVIFDGAKVEAGSVIERSILGFGVRIGPRALIRDGVIGDGADIGARCELLRGAR FT VWPGVSIPDGGIRYSSDV" FT misc_feature 207495..208190 FT /note="Pfam match to entry PF00483 NTP_transferase, FT Nucleotidyl transferase, score 227.00, E-value 2.7e-64" FT misc_feature 208281..208334 FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 16.60, FT E-value 0.59" FT misc_feature 208383..208436 FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 5.90, E-value FT 1.2e+02" FT misc_feature 208470..208523 FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 5.10, E-value FT 1.6e+02" FT CDS 208665..209426 FT /pseudo FT /transl_table=11 FT /gene="ML0754" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv3714c (Best blastx score 231)" FT CDS complement(209493..209753) FT /transl_table=11 FT /gene="ML0755" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCK5" FT /protein_id="CAC30264.1" FT /translation="MALREATKESGVADLRITPELTTIHVHPVTCSLSEPTRHLDLQFV FT AHALDGVHIVVSDESEALRWWPAEALRPKLTVARKSARRSR" FT CDS complement(209971..211638) FT /transl_table=11 FT /gene="ML0756" FT /product="probable DNA methylase" FT /note="Similar to Mycobacterium tuberculosis putative DNA FT methylase RV3263 OR MTCY71.03 TR:P96868 (EMBL:Z92771) fasta FT scores: E(): 0, 81.9% id in 541 aa and to Escherichia coli FT modification methylase eco57IM SW:MT57_ECOLI (P25240) fasta FT scores: E(): 0, 31.4% id in 525 aa. Contains PS00092 N-6 FT Adenine-specific DNA methylases signature." FT /db_xref="GOA:Q9CCK4" FT /db_xref="InterPro:IPR002296" FT /db_xref="UniProtKB/TrEMBL:Q9CCK4" FT /protein_id="CAC30265.1" FT /translation="MVITYIGAAPDTCSMTTFAGKTAASADKVRGGYYTPAPVARFLAR FT WVRQAGQKILEPSCGDGRILREIAALTTQAHGVELLAHEARKSRKFCSVDTENFFTWLS FT KTQVGSWDGVAGNPPYIRFGNWAADQRDPALELMRHVGLRPTKLTNAWVPFVVASTTLV FT RDGGRVGLVVPAELLQVTYAAQLREFLLSLYREIILVTFERLVFDGILQEVVLFCGVVG FT AGPAQIRTINLRDAESLNSLAESNLGVESAPALLHEKEKWTKYLLDPAQIRLLRKLKHA FT NAMTRFGEVADVDVGIVTGRNSFFTFTDADAHALKLRKHCVPLVSRSTQLAGIVYDTNC FT RANDIAAKHRTWLLDAPHHPTDSALVTHIDAGKRAGVDKGYKCSIRKPWWSTPSLWIPD FT LFMLRQIHLAPRLTVNAAAATSTDTVHRVRLIADVDPTALAAVFHNSATFAFAEIMGRS FT YGGGILELEPREAEQLPIPPPAYASTELGQDIDLLLKANEIEKALDIVDRRVLIDGLGL FT SPDLVAQCRTAWASLRDRRTKRGSRVNISRRPFDSPPS" FT misc_feature complement(211279..211299) FT /note="PS00092 N-6 Adenine-specific DNA methylases FT signature" FT CDS complement(211660..212352) FT /transl_table=11 FT /gene="ML0757" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCK3" FT /protein_id="CAC30266.1" FT /translation="MQPMPGINLPKDELTAFGRKWLFSSKFSKKDGMDFGTLIDVAVGG FT ALSVMLGNIPIVVPTASQLQPSQPDCVEVGAVRIVGGVRPQNFDVGYRPDGARIAFDSK FT TLNDHDSVGKNWQNMINDLATEATTVHSRFPSAVVGFVVAIPTPCLAPGARTNAIIGAL FT ARLGNRELVDEPDHRAEAMSLVSWDPVTGRVDSNLPDPQSPLRIERFNTDMYHSYHARF FT QGLPPHAT" FT CDS complement(212393..213766) FT /transl_table=11 FT /gene="ML0758" FT /product="putative oxidoreductase" FT /note="Similar to Mycobacterium tuberculosis conserved FT hypothetical protein RV3262 OR MTCY71.02 TR:P96867 FT (EMBL:Z92771) fasta scores: E(): 0, 82.2% id in 445 aa, and FT to Streptomyces coelicolor putative oxidoreductase SCE34.18 FT TR:CAB88921 (EMBL:AL353862) fasta scores: E(): 0, 50.8% id FT in 455 aa. Contains Pfam match to entry PF00881 FT Nitroreductase, Nitroreductase family. Contains Pfam match FT to entry PF01996 DUF129, Protein of unknown function." FT /db_xref="GOA:Q9CCK2" FT /db_xref="InterPro:IPR000415" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCK2" FT /protein_id="CAC30267.1" FT /translation="MTSSDSHRSAPSPEHGTASTIEILPVAGLPEFRPGDDLSAALAAA FT APWLRDGDVVVVTSKVVSKCEGRLVPAPEDTRGRNELRRKLINDETIRVLARKGRTLII FT ENGLGLVQAAAGVDGSNVGRGELALLPVNPDASAAVLRIGLRAMLGVNVAVVITDTMGR FT AWRNGQTDVAIGAAGLAVLHNYSGAVDRYGNELVVTEIAVADEVAAATDLVKGKLTAMP FT VAVVRGLSPTDDGSTAQHLLRNGPDDLFWLGTTEALELGRQQAQLLRRSVRQFSDEPIA FT AELIETAVAEALTAPAPHHTRPVRFVWLQTPAVRTRLLDRMADKWRLDLASDALPADAI FT AQRVARGQILYDAPEVIIPFMVPDGAHAYPDAARASAEHTMFIVAVGAAVQALLVALAV FT RGLGSCWIGSTIFADDLVRAELELPADWEPLGAIAIGYAHEPTDLREPVRVADLLLRK" FT misc_feature complement(212501..212986) FT /note="Pfam match to entry PF00881 Nitroreductase, FT Nitroreductase family, score 23.70, E-value 6.3e-05" FT misc_feature complement(213011..213706) FT /note="Pfam match to entry PF01996 DUF129, Protein of FT unknown function, score 329.50, E-value 3.9e-95" FT CDS complement(213763..214902) FT /transl_table=11 FT /gene="ML0759" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 35.3 kDa protein RV3261 OR MTCY71.01 TR:P96866 FT (EMBL:Z92771) fasta scores: E(): 0, 79.0% id in 333 aa and FT to Streptomyces coelicolor hypothetical 33.6 kDa protein FT SCE34.17 TR:CAB88920 (EMBL:AL353862) fasta scores: E(): 0, FT 52.7% id in 334 aa. Contains Pfam match to entry PF01933 FT UPF0052, Uncharacterised protein family." FT /db_xref="GOA:Q9CCK1" FT /db_xref="InterPro:IPR010115" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCK1" FT /protein_id="CAC30268.1" FT /translation="MSSASGHKLCADLFPPSLFHGVLWVGLNAPTLPRKQAVSRAVLSC FT GVRVTVLVGGVGGAHFLLGVQQLLGLGQFGPQQCPDTLTTGHELTAVVNIGDDAWIHGL FT RVCPDLDTCMYTLGDGIDPQRGWGHRDETWHAKEELARYGVQPDWFELGDRDLATHLVR FT TQMLNAGYRLSQITTALCDRWQPGARLVPASDDRCETHVVITDPINDSRRAIHFQEWWV FT RYRAQVPTHSFAYVGAEKASAATEAVAAIADADVILVAPSNPVVSIGAILAIPGIRGAL FT RTTTAPVVGYSPIIDGKPLRGMADKCLTVIGVQSTATAVGQHYGARRTTGILDCWLVHE FT DDHAEIEGVAVRSIPLLMSSPKTTADMVNIGLQLAGVSA" FT misc_feature complement(213769..214758) FT /note="Pfam match to entry PF01933 UPF0052, Uncharacterised FT protein family, score 638.90, E-value 2.8e-188" FT CDS 215227..215496 FT /transl_table=11 FT /gene="whiB2" FT /gene_synonym="ML0760" FT /product="putative transcriptional regulator" FT /note="Similar to Mycobacterium tuberculosis regulatory FT protein whiB2 OR RV3260C OR MTV015.05C TR:O53353 FT (EMBL:AL021840) fasta scores: E(): 0, 85.4% id in 89 aa, to FT Mycobacterium smegmatis whmD TR:Q9S426 (EMBL:AF164439) FT fasta scores: E(): 1.6e-29, 84.1% id in 82 aa and to FT Streptomyces coelicolor regulatory protein WHIB TR:Q53963 FT (EMBL:X62287) fasta scores: E(): 4.8e-26, 85.5% id in 69 FT aa." FT /note="Similar to ML0382, ML0639, ML0804 and ML2307" FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q9CCK0" FT /protein_id="CAC30269.1" FT /translation="MVPKALVAFEVESEPESSDQWQDRALCAQTDPEAFFPEKGGSTRE FT AKKICLGCEVRHECLEYALAHDERFGIWGGLSERERRRLKRGVI" FT CDS complement(215525..216028) FT /transl_table=11 FT /gene="ML0761" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 15.6 kDa protein RV3259 OR MTV015.04 TR:O53352 FT (EMBL:AL021840) fasta scores: E(): 0, 89.2% id in 139 aa FT and to Mycobacterium smegmatis hypothetical 6.0 kDa protein FT (partial CDS) TR:Q9S425 (EMBL:AF164439) fasta scores: E(): FT 1e-10, 75.5% id in 53 aa." FT /db_xref="UniProtKB/TrEMBL:Q9CCJ9" FT /protein_id="CAC30270.1" FT /translation="MSNSCSSSRHGQWSRRFSSRRAAKRGRDIRGPLLPPTVPGWRSRA FT ERFDMAVLEAYEPIEQRWQGRVSELDVAVDEIPRIAARNPENVQWPPEVIADGPIALAR FT LIPAGVDVRSNATRARIVLFRKPIERRAHDTVELGELLHDILVAQVAIYLDVEPSAIDP FT TMDD" FT CDS 216068..216565 FT /transl_table=11 FT /gene="ML0762" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 16.8 kDa protein RV3258C OR MTV015.03C TR:O53351 FT (EMBL:AL021840) fasta scores: E(): 0, 76.9% id in 169 aa, FT and to Streptomyces coelicolor hypothetical 15.0 kDa FT protein SCE34.11C TR:CAB88914 (EMBL:AL353862) fasta scores: FT E(): 4.8e-16, 47.0% id in 151 aa." FT /db_xref="UniProtKB/TrEMBL:Q9CCJ8" FT /protein_id="CAC30271.1" FT /translation="MRVSGASATFSHDSLSVVNVPRRCCRPGCPHYAVATLTFVYSDST FT AVVGPLATVREPHSWDLCVDHAARITAPRGWELVRHAGPLPSNPDEDDLVALADAVREG FT PGGEHGSYGNGARASLGGFADPQLQSAGAHATVPSGGLLAPSELRSGRRRGHLRVLPDP FT SD" FT RBS 216664..216669 FT /note="possible RBS" FT CDS 216675..218081 FT /transl_table=11 FT /gene="pmmA" FT /gene_synonym="ML0763" FT /product="putative phosphomannomutase" FT /note="Similar to Mycobacterium tuberculosis pmmA, RV3257C, FT putative phosphomannomutase, TR:O86374 (EMBL:Z95121) fasta FT scores: E(): 0, 83.1% id in 468 aa and to Escherichia coli FT phosphomannomutase manB SW:MANB_ECOLI (P24175) fasta FT scores: E(): 0, 39.0% id in 451 aa. Contains Pfam match to FT entry PF00408 PGM_PMM, FT Phosphoglucomutase/phosphomannomutase." FT /note="Similar to ML0366 and ML0706" FT /db_xref="GOA:Q9CCJ7" FT /db_xref="HSSP:1K2Y" FT /db_xref="InterPro:IPR016055" FT /db_xref="UniProtKB/TrEMBL:Q9CCJ7" FT /protein_id="CAC30272.1" FT /translation="MSRPAAAVHRVVKAYDVRGLVGKEIDESLSADFGAAFARLMRAEG FT ARQVVLGYDMRDSSPSLAAAFATGVTGQGVDVVRIGLSSTDQLYFAAGLLDCPGAMFTA FT SHNPAAYNGIKLCLAGAKPVGADTGLAIIRDDVIAGIPPYPLSRGRPGTIADRDVLADY FT GVFLRSLVNTAGLRPLRVAVDAGNGMAGHTTPAVLGAIDSITLLPLYFELDGSFPNHEA FT NPLDPANLVDLQAYVRDTGADIGLAFDGDADRCFVVDERGLSVSPSTVTSLVAARALKR FT EIGATIIYNVITSRAVPELVSECGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHYYFR FT DFWGADSGMLAALYVLAALGEQQRPLSELAADYQRYESSGEINFTVADAPSCMDAVVEF FT FGSQIHSIDHLDGVTVDLGGGSWFNLRNSNTEPLLRLNVEGRSTEDVDVVVAQISAQIA FT AHISGPEAEP" FT misc_feature 216696..218015 FT /note="Pfam match to entry PF00408 PGM_PMM, FT Phosphoglucomutase/phosphomannomutase, score 385.40, FT E-value 5.5e-112" FT RBS 218066..218070 FT /note="possible RBS" FT CDS 218078..219175 FT /transl_table=11 FT /gene="ML0764" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 35.3 kDa protein RV3256C OR MTV015.01C-MTCY20B11.31C FT TR:O05899 (EMBL:Z95121) fasta scores: E(): 0, 75.3% id in FT 365 aa." FT /db_xref="UniProtKB/TrEMBL:Q9CCJ6" FT /protein_id="CAC30273.1" FT /translation="MNATRLIDLEDTKGLIAADRDGLLRAASSAGAQVRAIAAAAEEGA FT LETLRAHDRPRTVIWVAGRGTAETAGAMLAATSGGATTEPIVVASEAPPWVGPLDVLIV FT AGDDPGDPALVGAAATAVGRGARVVVVAPYEGPLRDATAGRVAVLEPRLRIPNEFGLCR FT YLAAGLAALQTVDPRLRLDLAMLADELDSEALHNSVGYEVFTNPAKTLAASVSGHRVAL FT AGDCAATLALARHGSSVLLRIAHQVTSATGLSDAVVAVRSSVDVADYAPTSVDVLFHDE FT EIDGSLPERLRVLALTLASERTVVAARVVGLDDVYLVAAEDVPDGPSGLAGLPVSGGAD FT RAEQELAMLAVRLEMAAVYLRLVRG" FT CDS 219183..220415 FT /transl_table=11 FT /gene="manA" FT /gene_synonym="ML0765" FT /product="putative mannose-6-phosphate isomerase" FT /note="Similar to Mycobacterium tuberculosis manA OR FT RV3255C OR MTCY20B11.30C, putative mannose-6-phosphate FT isomerase, TR:O05898 (EMBL:Z95121) fasta scores: E(): 0, FT 84.4% id in 411 aa and to Homo sapiens mannose-6-phosphate FT isomerase mpi SW:MANA_HUMAN (P34949) fasta scores: E(): FT 1.2e-27, 31.0% id in 432 aa. Contains Pfam match to entry FT PF01238 PMI_typeI, Phosphomannose isomerase type I." FT /db_xref="GOA:Q9CCJ5" FT /db_xref="HSSP:1PMI" FT /db_xref="InterPro:IPR014710" FT /db_xref="UniProtKB/TrEMBL:Q9CCJ5" FT /protein_id="CAC30274.1" FT /translation="MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDS FT VWLQAANGETSLLEALVADPEGQLGSVSRARFGDVLPFLVKVLAADEPLSLQAHPSTKQ FT AVEGYLREERLGIPVSSPERNYRDTSHKPELLVALQSFEALAGFRQSSRTAELLTALAV FT SDLDPFIHLLSDQSDADGLRALFTTWITAPQTDIDMLVPAVLEGAIAYVSSGATEFLAE FT VKTVMELGERYPGDAGVLASLLLNRISLTPGEAIFLPAGNLHAYLRGVGVEVMANSDNV FT LRGGLTPKHVDVPELLRVLDFNPTPEEALRPPTRCEGFAVVYETPTDEFEVALLALDGD FT YLGHEVDASPHDVSQGPQILLCTEGEITVHGKFQALTVERGMAVWMAADDGPIRLVAQQ FT PAKLFRATVGL" FT misc_feature 219189..220304 FT /note="Pfam match to entry PF01238 PMI_typeI, FT Phosphomannose isomerase type I, score 209.40, E-value FT 5.5e-59" FT CDS complement(220396..221753) FT /pseudo FT /transl_table=11 FT /gene="ML0766" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3254 (Best blastx score 402)" FT CDS 221846..223322 FT /pseudo FT /transl_table=11 FT /gene="ML0767" FT /product="probable cationic amino acid transporter FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3253c (Best blastx score 1109)" FT CDS 223577..224770 FT /pseudo FT /transl_table=11 FT /gene="ML0768" FT /product="possible alkane-1 monooxygenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3252c (Best blastx score 358)" FT CDS 224779..224895 FT /pseudo FT /transl_table=11 FT /gene="ML0769" FT /product="possible rubredoxin (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3251c (Best blastx score 105)" FT CDS 224998..225508 FT /pseudo FT /transl_table=11 FT /gene="ML0770" FT /product="transcriptional regulator (TetR/AcrR family) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3249c (Best blastx score 273)" FT RBS 225613..225616 FT /note="possible RBS" FT CDS 225623..227101 FT /transl_table=11 FT /gene="sahH" FT /gene_synonym="ML0771" FT /product="putative S-adenosyl-L-homocysteine hydrolase" FT /note="Similar to Mycobacterium tuberculosis FT adenosylhomocysteinase achY OR sahH OR RV3248C OR FT MTCY20B11.23C SW:SAHH_MYCTU (O08364) fasta scores: E(): 0, FT 91.4% id in 489 aa, and to Mycobacterium bovis FT S-adenosyl-L-homocysteine hydrolase TR:AAF72670 FT (EMBL:AF262755) fasta scores: E(): 0, 91.4% id in 489 aa, FT and to Trichomonas vaginalis adenosylhomocysteinase FT SW:SAHH_TRIVA (P51540) fasta scores: E(): 0, 62.3% id in FT 478 aa. Contains Pfam match to entry PF00670 AdoHcyase, FT S-adenosyl-L-homocysteine hydrolase. Contains PS00739 FT S-adenosyl-L-homocysteine hydrolase signature 2. Contains FT PS00738 S-adenosyl-L-homocysteine hydrolase signature 1." FT /db_xref="GOA:Q9CCJ4" FT /db_xref="HSSP:1B3R" FT /db_xref="InterPro:IPR020082" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCJ4" FT /protein_id="CAC30280.1" FT /translation="MTTTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMS FT LRHEYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVV FT VGPYGTPEEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPVNMILDDGGDATMLVLR FT GVQYEKAGVVPPAEVDDSAEWKVFLNLLRKRFETDKGKWTKIAKSVKGVTEETTTGVLR FT LYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYG FT DVGKGCAEAAKGQGARVTITEIDPINALQALMEGFDVKRVEDVIADSDIVVTATGNKDI FT ILLEHMKAMKDHAILGNIGHFDNEIDMAALERSGATRLNIKPQVDLWTFGDSGKSIIVL FT SEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDDYDNEVYRLPKHLDEKVARVH FT VEALGGQLTKLTKDQAEYLGVDVDGPFKPDHYRY" FT misc_feature 225677..226927 FT /note="Pfam match to entry PF00670 AdoHcyase, FT S-adenosyl-L-homocysteine hydrolase, score 943.80, E-value FT 4.6e-280" FT misc_feature 225887..225931 FT /note="PS00738 S-adenosyl-L-homocysteine hydrolase FT signature 1" FT misc_feature 226436..226486 FT /note="PS00739 S-adenosyl-L-homocysteine hydrolase FT signature 2" FT CDS 227144..227776 FT /transl_table=11 FT /gene="tmk" FT /gene_synonym="ML0772" FT /product="putative thymidylate kinase" FT /note="Similar to Mycobacterium tuberculosis putative FT thymidylate kinase MTCY20B11 OR RV3247C OR MTCY20B11.22C FT TR:O05891 (EMBL:Z95121) fasta scores: E(): 0, 77.3% id in FT 207 aa, and to Homo sapiens thymidylate kinase tymK OR tmpK FT SW:KTHY_HUMAN (P23919) fasta scores: E(): 0.005, 29.1% id FT in 196 aa. Contains Pfam match to entry PF02223 FT Thymidylate_kin, Thymidylate kinase. Contains PS01331 FT Thymidylate kinase signature. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q9CCJ3" FT /db_xref="HSSP:1N5L" FT /db_xref="InterPro:IPR018095" FT /db_xref="UniProtKB/TrEMBL:Q9CCJ3" FT /protein_id="CAC30281.1" FT /translation="MLIAIEGVDGAGKRTLSEELRQAFEATGKSVATLAFPRYRQSVAA FT DIAAEALHGQHGDLASSVYAMALLFAFDRAGAVEDIEALDRNHDIVILDRYVASNAAYS FT AARLHEDCSGRAVAWVQRIEYQRLRLPSPDWQVLLAVSVELAGKRSRYRARTDPDRLRD FT SYERDDGLQQRTGAVYAGLAAADWGGRWLVVDADIDSGWLVATLMGC" FT misc_feature 227156..227764 FT /note="Pfam match to entry PF02223 Thymidylate_kin, FT Thymidylate kinase, score 160.70, E-value 2.5e-44" FT misc_feature 227210..227233 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 227417..227455 FT /note="PS01331 Thymidylate kinase signature" FT misc_feature 227741..227773 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 227869..228555 FT /transl_table=11 FT /gene="mtrA" FT /gene_synonym="ML0773" FT /product="putative two-component response regulator" FT /note="Similar to Mycobacterium tuberculosis mtra protein FT mtrA OR RV3246C OR MTCY20B11.21C TR:Q50447 (EMBL:Z95121) FT fasta scores: E(): 0, 98.7% id in 228 aa, to Mycobacterium FT bovis sensory transduction protein regX3 SW:RGX3_MYCBO FT (O07130) fasta scores: E(): 0, 50.2% id in 221 aa, and to FT Streptomyces coelicolor transcriptional regulatory protein FT afsQ1 SW:AFQ1_STRCO (Q04942) fasta scores: E(): 0, 47.1% FT id in 221 aa. Contains Pfam match to entry PF00486 FT trans_reg_C, Transcriptional regulatory protein, C FT terminal. Contains Pfam match to entry PF00072 FT response_reg, Response regulator receiver domain." FT /note="Similar to ML0174, ML1286, ML2123 and ML2439" FT /db_xref="GOA:Q9CCJ2" FT /db_xref="HSSP:1B00" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCJ2" FT /protein_id="CAC30282.1" FT /translation="MDIMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAV FT RELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIM FT KPFKPKELVARVRARLRRNDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFDLLV FT ALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG FT YKAGPP" FT misc_feature 227884..228216 FT /note="Pfam match to entry PF00072 response_reg, Response FT regulator receiver domain, score 129.60, E-value 5.8e-35" FT misc_feature 228316..228534 FT /note="Pfam match to entry PF00486 trans_reg_C, FT Transcriptional regulatory protein, C terminal, score FT 111.50, E-value 4.7e-32" FT CDS 228683..230371 FT /transl_table=11 FT /gene="mtrB" FT /gene_synonym="ML0774" FT /product="putative two-component system sensor kinase" FT /note="Similar to Mycobacterium tuberculosis mtrB, probable FT sensor histidine kinase, TR:Q50496 (EMBL:U14909) fasta FT scores: E(): 0, 88.3% id in 566 aa. Contains hydrophobic, FT possible membrane-spanning region. Contains Pfam match to FT entry PF00672 DUF5, Domain found in bacterial signal FT proteins. Contains Pfam match to entry PF00512 signal, FT Histidine kinase." FT /note="Similar to ML0175, ML2124 and ML2440" FT /db_xref="GOA:Q9CCJ1" FT /db_xref="InterPro:IPR005467" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCJ1" FT /protein_id="CAC30283.1" FT /translation="MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVAL FT TFGLSLAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSLDSSL FT QLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKAGQA FT AYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGGMVL FT LVLLSGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAES FT LSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSSDLDPTLRRSTELMV FT SELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDM FT PVDEVIAEVDARRVERILRNLIANAIDHSEHKPVRIRMAADEDTVAVTVRDYGIGLRPG FT EEKLVFSRFWRSDPSRVRRSGGTGLGLAISIEDARLHQGRLEAWGEPGQGACFRLTLPL FT VRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLREHAERSR" FT misc_feature 229325..229534 FT /note="Pfam match to entry PF00672 DUF5, Domain found in FT bacterial signal proteins, score 69.10, E-value 9.1e-17" FT misc_feature 229595..230230 FT /note="Pfam match to entry PF00512 signal, Histidine FT kinase, score 189.50, E-value 5.2e-53" FT RBS 230360..230364 FT /note="possible RBS" FT CDS 230368..232137 FT /transl_table=11 FT /gene="lpqB" FT /gene_synonym="ML0775" FT /product="putative lipoprotein" FT /note="Similar to Mycobacterium tuberculosis putative FT lipoprotein RV3244C OR MTCY20B11.19C TR:O05889 FT (EMBL:Z95121) fasta scores: E(): 0, 87.9% id in 579 aa, and FT to Streptomyces coelicolor putative lipoprotein SCE33.13C FT TR:CAB90922 (EMBL:AL355774) fasta scores: E(): 0.00039, FT 24.4% id in 624 aa. Contains a probable N-terminal signal FT sequence. Contains PS00013 Prokaryotic membrane lipoprotein FT lipid attachment site." FT /db_xref="GOA:Q9CCJ0" FT /db_xref="InterPro:IPR019606" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCJ0" FT /protein_id="CAC30284.1" FT /translation="MMRGVLVIMRLLCLGMLFTGCAGVPNSSAPQAIGTVERPVPSNLP FT KPTPGMDPDVLLREFFKATADPANRHLAARQFLTQSASNAWDDAGRALLIDHVVFVETR FT GAERVSATMRADILGSLSDMGVFETAEGVLPDPGPVELIKTSGGWRIDRLPNGVFLDWQ FT QFQATYKRNTLYFADPTGKTVVPDPRYVAVLGHDQLATELVSKLLAGPRPEMAHAVRNL FT LAPPLRLRGPVTRADGSKSGIGRGYGGARIDLEKLSTTDPHSRQLLAAQIIWTLARADI FT RGPYVINADGAPLDDRFADGWTTSDVAATDPGVADGAGAGLHALVGGALVSLIGQNTTT FT VLGAFGRMGYQTGAALSRSGRQVASVVTLRRGAPDMAASLWIGDLGGEAVQSADGHSLS FT RPSWSLDDAVWVVVDTNNVLRAIPEPASGQPARIPVDSAAVASRFPGPITDLQLSRDGT FT RAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDATH FT PVSYVNLDGVNSDAPARGLQVPLSVIAANPSTVYVAGPQGVLQYSASVAESQQGWSEVA FT GLTVMGAEPVLPG" FT misc_feature 230398..230430 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 232258..232515 FT /transl_table=11 FT /gene="ML0776" FT /note="Similar to the N-terminal half of Mycobacterium FT tuberculosis hypothetical 22.5 kDa protein RV3242C OR FT MTCY20B11.17C TR:O05887 (EMBL:Z95121) fasta scores: E(): FT 6.8e-18, 78.1% id in 64 aa." FT /db_xref="UniProtKB/TrEMBL:Q9CCI9" FT /protein_id="CAC30285.1" FT /translation="MAGCGVFATRWSDACTAELSVAAGEPRVVSLCVDPLVPVVVLGRY FT VGARRQAILAMKEHGRRNLVALPTRQCVSRLGSCTLPGRG" FT CDS 232655..232849 FT /transl_table=11 FT /gene="ML0777" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCI8" FT /protein_id="CAC30286.1" FT /translation="MARRTRANVEGNFLETYWGFSVAIFLAALLATGGEKIDILHRRAA FT CAVDFSQNRSHPVGVVLYS" FT CDS 232953..233642 FT /transl_table=11 FT /gene="ML0778" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 24.5 kDa protein RV3241C OR MTCY20B11.16C TR:O05886 FT (EMBL:Z95121) fasta scores: E(): 0, 89.3% id in 206 aa and FT to Spinacia oleracea 30s ribosomal protein S30, chloroplast FT precursor RPS30 OR RPS22 SW:RR30_SPIOL (P19954) fasta FT scores: E(): 1.3e-10, 26.8% id in 213 aa." FT /db_xref="GOA:Q9CCI7" FT /db_xref="InterPro:IPR003489" FT /db_xref="UniProtKB/TrEMBL:Q9CCI7" FT /protein_id="CAC30287.1" FT /translation="MSRLTVGFGQVLNSAPVPSDEQVEPMPNVEIVFKGRNVEIPDHFR FT IHVSQRLARLERFDRTIYLFDVELDHERNRRQRKFCQRVEITARGRGPVVRGEACADSF FT YAALESAVVKLESRLRRGKDRRKVHYGDKTPVSVAEATAVAVSPEKAFNTEPAPAHDHG FT GAVTDYEPGRIVRTKEHPAKPMSVDDALYEMELVGHDFFLFLDKQSERPSVVYRRHAYD FT YGLIRLA" FT CDS 233722..236544 FT /transl_table=11 FT /gene="secA" FT /gene_synonym="ML0779" FT /product="putative preprotein translocase subunit" FT /note="Similar to Mycobacterium tuberculosis preprotein FT translocase secA 1 subunit OR SECA OR RV3240C OR FT MTCY20B11.15C SW:SEA1_MYCTU (O05885) fasta scores: E(): 0, FT 87.5% id in 949 aa and to Mycobacterium bovis preprotein FT translocase secA subunit SECA SW:SECA_MYCBO (P71494) fasta FT scores: E(): 0, 85.9% id in 949 aa. Contains Pfam match to FT entry PF01043 SecA_protein, SecA protein, amino terminal FT region. Contains PS01312 Protein secA signatures." FT /note="Similar to ML2082" FT /db_xref="GOA:P57996" FT /db_xref="HSSP:1NKT" FT /db_xref="InterPro:IPR011116" FT /db_xref="UniProtKB/Swiss-Prot:P57996" FT /protein_id="CAC30288.1" FT /translation="MLSKLLRLGEGRIVKRLKRVAEYVNTLSDNVEKLTDVELKAKTDE FT FKQRLADEKNPESLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGGAALHLGNVAEMKTG FT EGKTLTCVLPAYLNALAGKGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILASMTPD FT ERRVAYNADITYGTNNEFGFDYLRDNMAHSLDDLVQRGHSYAIVDEVDSILIDEARTPL FT IISGSADGASNWYTEFARLVRLMDKDVHYEVDLRKRTVGVHEKGMEFVEDQLGIDNLYE FT VANSPLVSYLNNALKAKELFNRDKDYIVRDGEVLIVDEFTGRVLIGRRYNEGMHQAIEA FT KEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVAIPTNKPM FT IREDRSDLIYKTEEAKYMAVVDDVAERYEKGQPVLIGTTSVERSEYLSRQFTKRHIPHN FT VLNAKYHEQEAGIVAVAGRRGGVTVATNMAGRGTDIVLGGNVDFLTDQRLRRRGLDPVE FT TPDEYEQAWHSELPKVKEEAGQEAAEVIEAGGLYVLGTERHESRRIDNQLRGRSGRQGD FT PGESRFYLSLGDELMRRFHGATLEALLTRLNLPDDVPIEAKMVTRAIKSAQTQVEQQNF FT EVRKNVLKYDEVMNQQRKVIYAERRRILEGESLQQQALGMVRDVITAYIDGATTDSYVE FT DWDLDALWSALGTLYPVGIKHESLTHADEDSECDELSRDELLEALLIDAQHAYAAREAE FT LAELAGEGAMRQLERNVLLNVVDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGY FT DMFMAMLDGVKEESVGFLFNLAVEAVPASHVAPVEIPEGFTGLVADVEAIRPREEASSA FT LRTKDIDNESTGLTYSGPSEDGSTQVQLNSGGGQKTPAGIPVGASRRERREAARRRGRG FT AKPSRSVKKR" FT misc_feature 233725..234978 FT /note="Pfam match to entry PF01043 SecA_protein, SecA FT protein, amino terminal region, score 1050.40, E-value 0" FT misc_feature 235162..235209 FT /note="PS01312 Protein secA signatures" FT CDS 236814..237329 FT /pseudo FT /transl_table=11 FT /gene="ML0780" FT /product="putative membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3238c (Best blastx score 169)" FT CDS 237681..238163 FT /transl_table=11 FT /gene="ML0781" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 17.2 kDa protein RV3237C OR MTCY20B11.12C TR:O05882 FT (EMBL:Z95121) fasta scores: E(): 0, 80.6% id in 160 aa, to FT Deinococcus radiodurans conserved hypothetical protein FT DR1148 TR:Q9RV81 (EMBL:AE001964) fasta scores: E(): FT 1.1e-19, 38.0% id in 158 aa and to Streptomyces coelicolor FT hypothetical 17.1 kDa protein SC66T3.12 TR:Q9XAK1 FT (EMBL:AL079348) fasta scores: E(): 5.5e-14, 37.9% id in 153 FT aa." FT /db_xref="GOA:Q9CCI6" FT /db_xref="InterPro:IPR006037" FT /db_xref="UniProtKB/TrEMBL:Q9CCI6" FT /protein_id="CAC30290.1" FT /translation="MDVKEVLLPGVGLRYEFTSRKGDRIGIIARRSGDFDVVVYARDDP FT DWAQPVFCLTDDEAEAVAQILGAPRIAERFTELASEVPGLETRQVRIAPESLFVDRPLG FT DTHARTRTGASIVAIVRDEDVVVSPGPAEPLRARDVLIVIGTEEGIAGVEQIIDKG" FT CDS 238168..239325 FT /transl_table=11 FT /gene="ML0782" FT /product="putative transmembrane transport protein" FT /note="Similar to Mycobacterium tuberculosis putative FT transmembrane transport protein RV3236C OR MTCY20B11.11C FT TR:O05881 (EMBL:Z95121) fasta scores: E(): 0, 81.8% id in FT 385 aa, and to Escherichia coli glutathione-regulated FT potassium-efflux system protein kefB OR trkB SW:KEFB_ECOLI FT (P45522) fasta scores: E(): 4.7e-13, 26.0% id in 362 aa. FT Contains hydrophobic, possible membrane-spanning regions." FT /db_xref="GOA:Q9CCI5" FT /db_xref="InterPro:IPR006153" FT /db_xref="UniProtKB/TrEMBL:Q9CCI5" FT /protein_id="CAC30291.1" FT /translation="MEISGALLSQVGALLTTLAVLGAGARRYSLSPIPVYLMAGLSLGK FT GGIMPVSAADEFITTGAPIGIVLLLLTLGLEFSATEFASSLRRHLPSAGVDIILNATPG FT AVAGWLLGLDGVAVLALAGVTYISSSGVIARLLADLRRLGNRETPAVLSVLVLEDFAMA FT AYLPLFAVLAAGGSWLDAVVGMIVAVCALFAAFAASYHWGHHVGRLVAHPDSEQLLLRV FT LGVTLIVAAVAESLHASAAVGAFLVGLTLTGDTAERARKVLGPLRDLFAAIFFLAIGIS FT VDPHKLLPMFPTALILATVTAVTKVATGILAARYDGVARRGQLRAGTALVARGEFSLII FT IGLVGTSTPAVAALATAYVFIMAIAGPVLARYTPGSLPTSSGSAN" FT CDS complement(239401..239982) FT /pseudo FT /transl_table=11 FT /gene="ML0783" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3235 (Best blastx score 155)" FT CDS 240181..240874 FT /pseudo FT /transl_table=11 FT /gene="ML0784" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3234c (Best blastx score 286)" FT CDS 240967..241496 FT /pseudo FT /transl_table=11 FT /gene="ML0785" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3233c (Best blastx score 202)" FT CDS 241727..242223 FT /pseudo FT /transl_table=11 FT /gene="ML0786" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3232c (Best blastx score 85)" FT CDS 242316..242630 FT /pseudo FT /transl_table=11 FT /gene="ML0787" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3231c (Best blastx score 184)" FT CDS 242894..243942 FT /pseudo FT /transl_table=11 FT /gene="ML0788" FT /product="putative oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3230c (Best blastx score 278)" FT CDS 244051..245307 FT /pseudo FT /transl_table=11 FT /gene="desA3" FT /gene_synonym="ML0789" FT /product="acyl-[ACP] desaturase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT desA3 (Best blastx score 343)" FT CDS complement(245510..246326) FT /pseudo FT /transl_table=11 FT /gene="ML0790" FT /product="beta-ketoadipyl-CoA thiolase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT putative beta-ketoadipyl CoA thiolases (Best blastx score FT 143)" FT CDS complement(246528..247511) FT /transl_table=11 FT /gene="ML0791" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 34.9 kDa protein RV3228 OR MTCY20B11.03 TR:O05873 FT (EMBL:Z95121) fasta scores: E(): 0, 84.0% id in 331 aa. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q9CCI4" FT /db_xref="InterPro:IPR004881" FT /db_xref="UniProtKB/TrEMBL:Q9CCI4" FT /protein_id="CAC30300.1" FT /translation="MKPDNYYDESDVKIRSGRGSRPRTKTRPEHADAKAAMVVSVDRGR FT WGCALDNCPDRRITAMRARELGHTPIVVGDNVEVVGDLSGRPDTLARIVRRLQRRTVLR FT RTADDTDTSERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLAPILCLTKTDL FT APLEPFAKQFVDLDLTVVTAGVGDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEA FT NRSVGEVTDTGRGRHTSTQSVALPLEGSGWVIDTPGIRSFGLAHIRPDDVVLAFSDLTE FT ATEDCPRGCRHIGPPADPECTLDNISGPAVRRVAATRRLLAVLRET" FT misc_feature complement(246876..246899) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(247508..248800) FT /transl_table=11 FT /gene="aroA" FT /gene_synonym="ML0792" FT /product="putative 3-phosphoshikimate 1-carboxyvinyl FT transferase" FT /EC_number="2.5.1.19" FT /note="Similar to Mycobacterium tuberculosis FT 3-phosphoshikimate 1-carboxyvinyltransferase aroA OR RV3227 FT OR MTCY20B11.02 SW:AROA_MYCTU (P22487) fasta scores: E(): FT 0, 79.0% id in 428 aa, and to Yersinia enterocolitica FT 3-phosphoshikimate 1-carboxyvinyltransferase aroA FT SW:AROA_YEREN (P19688) fasta scores: E(): 1.2e-31, 33.1% id FT in 432 aa. Contains Pfam match to entry PF00275 FT EPSP_syntase, EPSP synthase (3-phosphoshikimate FT 1-carboxyvinyltransferase). Contains PS00885 EPSP synthase FT signature 2." FT /db_xref="GOA:Q9CCI3" FT /db_xref="InterPro:IPR006264" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCI3" FT /protein_id="CAC30301.1" FT /translation="MSIESWTAPVASTPVQANVTIPGSKSQTNRALMLAALAAAQGQGT FT STIGGALRSRDTELMISALRTLGLHVDEAGSVLTVNGRITPGEDAQVDCGLAGTVLRFV FT PPLAALSANPVTFDGDEQARARPITPLLDALRGLGVPVDGVGLPFQVQGSGSVAGGTVA FT IDASASSQFVSGLLLCAASFTQGVTVQHTGSPVPSAPHIAMTVMMLRQAGVQVDDSVGN FT RWQVRPGTVAARHWVVEPDLTNAVAFLAAAAVSGGTVRITGWPKTSVQPADNILNILFR FT LNVVVNQTDSFLEVQGSTVYDGFDVDLRDVGELTPSVAALAALATPGSVSQLHGIAHLR FT GHETDRLAALSTEINRLGGDCQETSDGLIITATPLRPGVWRAYADHRMAMAGAIVGLRV FT SGVEVDDIGATHKTLPQFPQLWANMLKRSTG" FT RBS complement(247519..247525) FT /note="possible RBS" FT misc_feature complement(247538..248776) FT /note="Pfam match to entry PF00275 EPSP_syntase, EPSP FT synthase (3-phosphoshikimate 1-carboxyvinyltransferase), FT score 608.10, E-value 5.3e-179" FT misc_feature complement(247727..247783) FT /note="PS00885 EPSP synthase signature 2" FT RBS complement(248806..248812) FT /note="possible RBS" FT CDS 248847..249605 FT /transl_table=11 FT /gene="ML0793" FT /product="putative bacteriophage protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 27.6 kDa protein RV3226C OR MTCY20B11.01C TR:O05872 FT (EMBL:Z95121) fasta scores: E(): 0, 70.6% id in 252 aa, and FT to Bacteriophage SPBc2 yoqW protein TR:O64131 FT (EMBL:AF020713) fasta scores: E(): 4.8e-21, 36.5% id in 244 FT aa." FT /db_xref="InterPro:IPR003738" FT /db_xref="UniProtKB/TrEMBL:Q9CCI2" FT /protein_id="CAC30302.1" FT /translation="MAGVCGRFAVITSTALLAEKIKAVDEATVDAPNYNVAPTVPIATV FT VSRHSESDYEPTRRVRLMRWGLIPPWIKASSDGGPDIKGPLLINVRADKVATSPVFRNS FT AKSKRCLVPMDGWYEWQVNVDSALGKKASTTPFFINRDDGATLFMAGLWSVWQPANSSA FT MLLSCTIITTDAVGELAEIHDRMPLILAEYDWDVWLNPYIPLDPQLLARSPDVHDIDVR FT PVSTLVNSVRNNGPELLEPVLLQPGQITLL" FT CDS complement(249636..250913) FT /pseudo FT /transl_table=11 FT /gene="ML0794" FT /product="REP-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis REP-family FT proteins (Best blastx score 135)" FT CDS complement(251222..253360) FT /pseudo FT /transl_table=11 FT /gene="atsD" FT /gene_synonym="ML0795" FT /product="putative arylsulfatase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT atsD (Best blastx score 485)" FT CDS 254266..254442 FT /transl_table=11 FT /gene="ML0796" FT /product="hypothetical protein" FT /note="Similar to the N-termini of Mycobacterium FT tuberculosis putative response regulator RV0844C OR FT MTV043.37C TR:O53856 (EMBL:AL022004) fasta scores: E(): FT 0.2, 39.7% id in 63 aa and Streptomyces coelicolor absA2 FT OR SCE8.19 TR:Q53894 (EMBL:U51332) fasta scores: E(): 4.3, FT 38.5% id in 52 aa. May be a on ORF within a regulator FT protein pseudogene." FT /db_xref="UniProtKB/TrEMBL:Q7AQF5" FT /protein_id="CAC30305.1" FT /translation="MTYRTDQISVLADDYPVTRPGVVRTLTSSGRVEVSDGRMVLPAIR FT ELQPVVAFSTTRA" FT CDS complement(255529..256968) FT /pseudo FT /transl_table=11 FT /gene="PPE" FT /gene_synonym="ML0797" FT /product="PPE-family protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT PPE-family proteins (Best blastx score 193)" FT CDS complement(258524..260302) FT /transl_table=11 FT /gene="ML0798" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis ATP/GTP FT binding protein Rv2787 or MTV002.52 TR:O33329 FT (EMBL:AL008967) fasta scores: E(): 0, 76.5% id in 587 aa FT and to other M. tuberculosis hypothetical proteins. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="C-terminal half is similar to that of ML0048. Also FT similar to ML1536" FT /db_xref="UniProtKB/TrEMBL:Q9CCI1" FT /protein_id="CAC30307.1" FT /translation="MTTFRERRTMFDAAVASYQSGDKTSAGAAFARLTVENPDMSDSWL FT GRLACGDHNLDTLAGAHQHSEVLYSETRRVGLKDGDLRAEIAAPMYLTLTTWSRATIGL FT AYASALINAGRYDEASVALDDPVVTEDDDAALARQFVMATLFHQTRSWSNVLKVAEVPP FT QNSNTDDRNELTDAVAALASTAASNLGQFQFALELTERVSTTNPQVAADVALNRAWCLR FT ELGDDNAARAALTAAPVNDIPTTHNTAEPASRPQPTTFRHPYDDGRDLLVARRRPAAGD FT GWRKFVTKATLGRVNPEPSAKAEQTNELHRRICAPLADVHKVAFVSAKGGVGKTTITVA FT LGNTMARLRGDRVIAVDVDADLGDLSARFRERGGPQTNIEHFVSARNAKRYADVRVHTV FT MNNDRLEMLGAQNDPRSTYRLGPDDYETAMKILENHCNVILLDCGTPVNGPLFNKIVST FT VTGLVVVASDDVRGVEGALATLDWLDAHGYARLLQHTVVVLNAIQKTKPFVDFGIVENQ FT FRKRVPDFYPMPYDPHLATGLAVEYTSLKRKTRKALKELVGGVAQYYPVIRAQQRDEDG FT LGTWIETIRQVEMTSR" FT misc_feature complement(259298..259321) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT RBS complement(260312..260316) FT /note="possible RBS" FT repeat_region 260935..260964 FT /note="15 tandem copies of dinucleotide repeat, AT" FT CDS complement(261041..261448) FT /transl_table=11 FT /gene="ML0799" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium smegmatis hypothetical 19.1 FT kDa protein TR:Q9XCD9 (EMBL:AF144091) fasta scores: E(): FT 1e-15, 60.2% id in 93 aa and to other hypothetical proteins FT e.g. Salmonella typhimurium 17.0 kDa protein in ushA FT 3'region ybaK SW:YBAK_SALTY (P37174) fasta scores: E(): FT 6e-08, 40.9% id in 88 aa." FT /db_xref="HSSP:1DBX" FT /db_xref="InterPro:IPR007214" FT /db_xref="UniProtKB/TrEMBL:Q9CCI0" FT /protein_id="CAC30308.1" FT /translation="MQFDTVNNLSRNTLTPRLSRYSKTLIIALPRELAIAILSAPSRLS FT LKETAAAPGVTKANTAEPAAAQRATSYVVGGVFPSGQWKRLRTVVDTSALSWDRVLCNA FT GKRHRLLAPGCRGEPGYVRHPSGWRSAERCW" FT CDS complement(261526..262328) FT /pseudo FT /transl_table=11 FT /gene="ML0800" FT /product="putative oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3224 (Best blastx score 426)" FT CDS 262848..263067 FT /pseudo FT /transl_table=11 FT /gene="sigH" FT /gene_synonym="ML0801" FT /product="ECF subfamily sigma subunit (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT sigH (Best blastx score 162)" FT CDS 263240..263438 FT /pseudo FT /transl_table=11 FT /gene="ML0802A" FT /note="ML0802A. Possible pseudogene of Rv3222Ac, probable FT anti-sigma factor (Best blastx score 176)" FT CDS 263814..264053 FT /transl_table=11 FT /gene="ML0802" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 7.3 kDa protein Rv3221c or MTCY07d11.05 TR:O05845 FT (EMBL:Z95120) fasta scores: E(): 6.2e-19, 90.1% id in 71 aa FT and to the C-terminal half of Propionigenium modestum FT methylmalonyl-CoA decarboxylase, gamma-subunit mmdC (134 FT aa) TR:O54030 (EMBL:AJ002015) fasta scores: E(): 3.4e-06, FT 42.9% id in 70 aa. Contains Pfam match to entry PF00364 FT biotin_lipoyl, Biotin-requiring enzymes. Contains PS00445 FT FGGY family of carbohydrate kinases signature 2." FT /db_xref="HSSP:1IYU" FT /db_xref="InterPro:IPR000089" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCH9" FT /protein_id="CAC30312.1" FT /translation="MAEMSGVKMAEDVRAEIVASVLEVVVSEGDQIGKGDVLVLLESMK FT MEIPVLAGVAGIVSKVSVSVGDVIQAGDLIAVIS" FT misc_feature 263817..263882 FT /note="PS00445 FGGY family of carbohydrate kinases FT signature 2" FT misc_feature 263844..264047 FT /note="Pfam match to entry PF00364 biotin_lipoyl, FT Biotin-requiring enzymes, score 59.20, E-value 9.2e-14" FT RBS 264093..264098 FT /note="possible RBS" FT CDS 264103..265605 FT /transl_table=11 FT /gene="ML0803" FT /product="putative two-component system sensor kinase" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 54.0 kDa protein Rv3220c or MTCY07D11.06 TR:O05846 FT (EMBL:Z95120) fasta scores: E(): 0, 81.8% id in 501 aa and FT shows weak similarity to Pseudomonas aeruginosa alginate FT biosynthesis sensor protein kinB TR:O34206 (EMBL:U97063) FT fasta scores: E(): 1.3e-06, 26.9% id in 346 aa. Contains FT Pfam match to entry PF00512 signal, Histidine kinase." FT /db_xref="GOA:Q9CCH8" FT /db_xref="HSSP:1KZN" FT /db_xref="InterPro:IPR013656" FT /db_xref="UniProtKB/TrEMBL:Q9CCH8" FT /protein_id="CAC30313.1" FT /translation="MSTLGDLLAEHTVLPGNAVGHLHAVVGEWQLLADLSFADYLMWVS FT RDDGVLVCVAQCRPHTAPTVLQTDAVGSVASADMLPLVTEMFTSGAVQHEDAAGQQYSW FT LPFGRNVAASPVRYGDQVVAVLTQHQVELAARRRPGNLEIAYLACATDLLHMLAEGTFP FT DVGDVAVSHSTPRAGDGFIRLDRNGVVAFASPNALSAFHRMGLTAELQGRNLVKVTRPL FT LSDPFEAQEVAKHVQDLLDGGPSMRVEVNAGGATVLLRTLPLVVHGSSVGAAVLVRDVT FT EVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRMANAEGREALIESVRRVSS FT IALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGNLGMLDSDRATALI FT MVITELVQNAIEHAFDPASQEGFVAISAERSARWLDVVVHDDGRGLPQGFNLERSDSLG FT LQIVRTLVSSELDGSLGMRKAPNRGTDVVLRVPIGRRARLLL" FT misc_feature 265006..265575 FT /note="Pfam match to entry PF00512 signal, Histidine FT kinase, score -32.30, E-value 0.0027" FT CDS complement(265665..265919) FT /transl_table=11 FT /gene="whiB1" FT /gene_synonym="ML0804" FT /product="putative transcriptional regulator" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 9.3 kDa protein Rv3219 or MTCY07D11.07c TR:O05847 FT (EMBL:Z95120) fasta scores: E(): 0, 95.2% id in 84 aa, to FT Mycobacterium smegmatis whiB3 TR:Q9Z6E9 (EMBL:AF073300) FT fasta scores: E(): 2e-10, 43.2% id in 81 aa and to FT Streptomyces coelicolor WhiD protein whiD or SC6G4.45c or FT wblB TR:O88103 (EMBL:AJ010601) fasta scores: E(): 2.7e-10, FT 50.7% id in 75 aa." FT /note="Similar to ML0382, ML0639, ML0760 and ML2307" FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q9CCH7" FT /protein_id="CAC30314.1" FT /translation="MDWRHKAVCRDEDPELFFPVGNSGPAIAQIADAKLVCNRCPVTTE FT CLAWALNTGQDSGVWGGMSEDERRALKRRNTRTKARSGV" FT RBS complement(265928..265934) FT /note="possible RBS" FT CDS complement(266248..267184) FT /pseudo FT /transl_table=11 FT /gene="ML0805" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3218 (Best blastx score 324)" FT CDS 267206..267727 FT /transl_table=11 FT /gene="ML0806" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 14.3 kDa protein Rv3217c or MTCY07D11.09 TR:O05849 FT (EMBL:Z95120) fasta scores: E(): 0, 77.1% id in 140 aa. FT Contains hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CCH6" FT /protein_id="CAC30316.1" FT /translation="MDRVIALLSSGAIVGPCDYADVVTLPHKRAVFSRAPAAVRGAGLI FT VVVQGAVALVVAAALVVRGLTGADQRIVNGLGTAIWFVVVGVAVLAAGCALLVGKRWGR FT GLAVFTQLLLLPVAWYLVVGSHQSAFGFPMGIVALIALILLFSPPAVRWSAGAYQRSVA FT SSANRKADSR" FT CDS complement(267682..267997) FT /pseudo FT /transl_table=11 FT /gene="ML0807" FT /product="possible acyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3216 (Best blastx score 171)" FT CDS complement(268155..269888) FT /transl_table=11 FT /gene="entC" FT /gene_synonym="ML0808" FT /product="putative isochorismate synthase" FT /note="Similar to Mycobacterium tuberculosis putative FT isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 FT aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id FT in 366 aa and to Bacillus subtilis isochorismate synthase FT dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, FT 37.9% id in 396 aa. The predicted CDS has an N-terminal FT extension of approx. 210 aa not present in known FT isochorismate synthases. Contains Pfam match to entry FT PF00425 chorismate_bind, chorismate binding enzyme." FT /note="Similar to ML0236 and ML1269" FT /db_xref="GOA:Q9CCH5" FT /db_xref="HSSP:1K0G" FT /db_xref="InterPro:IPR005801" FT /db_xref="UniProtKB/TrEMBL:Q9CCH5" FT /protein_id="CAC30318.1" FT /translation="MAIRRGRNRASTFGCTELELTDTGRAQAKLAERALAEQKLVDPMM FT ASNPRQCDLVTAKLAGLTVDKVSPLLAECTYGSYEDLTTAKTREAEPAWLAWTHRYPRG FT EKRLASQRTCRPGRRYGVRALGVTDHVVRQPWPPLLGGDHTLDRAAICRGPALRYAHQL FT DWDVRVRVRATATTHAWVAWLATTGRTRVNINNDDDKRRPVAQERAEQMRPSEPPFALC FT GPRGTLVADGVHTRYDDVYLAQAALRSGVTPILLGALPFDAESPAALMAPSAVLRTDTL FT PNWQTGPLPTLRITAAVPTRANYRVWISNAREQLTAPGNSLHKVVLARALQLVADAPLD FT GRAILRRLVTADPTAYGYLVDLTAAGGQYAGVALVGASPELLVSRFGDRVVCRPFAGSA FT PRATNPEVDSANSAALAGSIKNRHEHQLVIDAIRAALEPVCDNLTIAPEPELSRTAAVW FT HLCTPISGRLRDTSITAIDLALMLHPTPAVGGVPAEAASELIAALEGDRGFYAGAVGWC FT DARGDGHWVVSIRCAQLSADRRIAFAHAGGGIVAESDPDDEVDETTAKFATILNALGVK FT Q" FT misc_feature complement(268170..268991) FT /note="Pfam match to entry PF00425 chorismate_bind, FT chorismate binding enzyme, score 237.20, E-value 6.5e-68" FT CDS 270210..270641 FT /pseudo FT /transl_table=11 FT /gene="ML0809" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3213c (Best blastx score 239)" FT CDS complement(270882..272105) FT /transl_table=11 FT /gene="ML0810" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 42.5 kDa protein Rv3212 or MTCY07D11.14c (407 aa) TR:O05854 FT (EMBL:Z95120) fasta scores: E(): 0, 79.9% id in 407 aa. FT Contains hydrophobic, possible membrane-spanning region." FT /db_xref="UniProtKB/TrEMBL:Q9CCH4" FT /protein_id="CAC30320.1" FT /translation="MVRPERRTKADTIAAMTITVVMAAMVSLIWWTSDAQATHSRPATI FT PAPNPTPAREVPTAFNQLWAAASPATTAPVVVGGAVITGDGHQIDGRNPVTGESRWSYA FT RDSDLCGVSWVYHYAVAVYRDDRGCGQVSTIDGSTGRREAARSSYADPHVRLSSDGTAV FT LSAGDTRLELWRSDMVRMLAYGEIDARVKPPARGLHSGCTLESTAASSSAVAVLEACAN FT QDDLQLVLLRPGKEDDEPQQHLVAEPRVRSGSGARVLTVSDTHTAVYLPGEAGTQPRVD FT VIDETGTTVASTLLTKPPSSSAVVSQAGNLVTWWTGDTLMVFNQSNLTLRYTIAAGETT FT APVGPGVMMAGQLLVPVTGKIGVYDLFSGANNRYIPVRRPPSSSAVIPAVSGSTVFEQR FT GDTLVALG" FT CDS complement(272117..273751) FT /transl_table=11 FT /gene="rhlE" FT /gene_synonym="ML0811" FT /product="putative ATP-dependent RNA helicase" FT /note="Similar to Mycobacterium tuberculosis putative FT ATP-dependent RNA helicase Rv3211 or MTCY07D11.15c (407 aa) FT TR:O05855 (EMBL:Z95120) fasta scores: E(): 0, 74.8% id in FT 531 aa, and to Klebsiella pneumoniae ATP-dependent RNA FT helicase deaD SW:DEAD_KLEPN (P33906) fasta scores: E(): 0, FT 43.2% id in 380 aa. Contains Pfam match to entry PF00271 FT helicase_C, Helicases conserved C-terminal domain. Contains FT Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT Contains PS00039 DEAD-box subfamily ATP-dependent helicases FT signature." FT /db_xref="GOA:Q9CCH3" FT /db_xref="HSSP:1QDE" FT /db_xref="InterPro:IPR014001" FT /db_xref="UniProtKB/TrEMBL:Q9CCH3" FT /protein_id="CAC30321.1" FT /translation="MNRDSKTPTQNRFSHRKAFHPHMTAPTSTAEPAFAKLGVRDEIVR FT ALAERGIQQPFAIQELTLPLALAGDDVIGQARTGMGKTFAFGVPLLQRISVTTTARPLS FT GAPRGLVVVPTRELCLQVADDLATVAKYLTADDDNRRFSVVSIYGGRAYEPQIEALQTG FT ADVVVSTPGRLLDLCQQGHLQLSGLSVLVLDEADEMLDLGFFPDIERLLGQIPTDRQSM FT LFSATMPDPIITLARTFMDQPIHIRAEAPHSLAVHDTTQQFVYRAHALDKVELISRILQ FT ARGRGATMIFTRTKRTAQKVTNELNERGFAVGAVHGDLGQIARENALEAFRTGNVDVLV FT ATDVAARGIDIDDVTHVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELHRWET FT IDKALGLGTPDPAETYSNSPHLYTELAIPAEASGTVGTPRKAQVKRRKTDRDGDKSGTS FT AQAAKAARTSNSVQRHRIRGGQPVTGHPTNNPSADSLATNGKVVAETLPNSSSGSPSTN FT VRRRRHRRKPTEVAENGLDKNLAVQAN" FT misc_feature complement(272612..272857) FT /note="Pfam match to entry PF00271 helicase_C, Helicases FT conserved C-terminal domain, score 119.80, E-value 5.3e-32" FT misc_feature complement(272966..273619) FT /note="Pfam match to entry PF00270 DEAD, DEAD/DEAH box FT helicase, score 200.20, E-value 2.2e-62" FT misc_feature complement(273152..273178) FT /note="PS00039 DEAD-box subfamily ATP-dependent helicases FT signature" FT misc_feature complement(273503..273526) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 273966..274652 FT /pseudo FT /transl_table=11 FT /gene="ML0812" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3210c (Best blastx score 523)" FT CDS complement(274707..275294) FT /transl_table=11 FT /gene="ML0813" FT /product="putative membrane protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 19.1 kDa protein Rv3209 or MTCY07D11.17c (186 aa) TR:O05857 FT (EMBL:Z95120) fasta scores: E(): 8.5e-23, 58.4% id in 185 FT aa and to Mycobacterium tuberculosis putative membrane FT protein mmpS3 or Rv2198c or MTCY190.09c (299 aa) FT SW:MMS3_MYCTU (Q10390) fasta scores: E(): 9.4e-08, 31.0% id FT in 203 aa. Contains hydrophobic, possible membrane-spanning FT region." FT /note="Similar to ML0431 and ML0877" FT /db_xref="UniProtKB/TrEMBL:Q9CCH2" FT /protein_id="CAC30323.1" FT /translation="MRLTETTSIRRTTTTSYSGHPIVDGRQVAALLGSVAALCAIATAV FT IINSGDNATTKAIVGAPTPRPVLTTPSIPLPATPSSTPPLLLLPDTATATIPHKAAPPA FT LHPRTVVYNVTGMKELLDLVTVVYTDARGYPKTEFNVVLPWTKAVVLNLGVKTQSVVAT FT SFHSQLHCSIVNAEGQPVVASTNNAVIATCTR" FT CDS 275593..275841 FT /transl_table=11 FT /gene="ML0814" FT /product="conserved hypothetical protein" FT /note="Unknown but equivalent to M.tuberculosis Rv3208c and FT similar to Streptomyces coelicolor hypothetical protein. FT FASTA scores: Rv3208c, E(): 3e-32, 82% identity in 82 aa; FT gp|AL390975|AL390975_32 Streptomyces coelicolor (94 aa) FT E(): 2.5e-09; 47.945% identity in 73 aa overlap" FT /db_xref="UniProtKB/TrEMBL:Q9CCH1" FT /protein_id="CAC30324.1" FT /translation="MEVKIGITDSPRELTFSSAQTPGEIEELVSAALREGLGLLVLTDE FT RGRRFLIHGAKIAYVEIGVADARRVGFGIGAESATNG" FT CDS complement(275828..276514) FT /transl_table=11 FT /gene="ML0815" FT /product="putative TetR-family transcriptional regulator" FT /note="Similar to Mycobacterium tuberculosis putative FT TetR-family transcriptional regulator Rv3208 or FT MTCY07D11.18c (228 aa) TR:O05858 (EMBL:Z95120) fasta FT scores: E(): 0, 82.4% id in 227 aa. Contains a probable FT helix-turn-helix motif at aa 60-81 (Score 1517, SD +4.35) FT Contains Pfam match to entry PF00440 tetR, Bacterial FT regulatory proteins, tetR family." FT /db_xref="GOA:Q9CCH0" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q9CCH0" FT /protein_id="CAC30325.1" FT /translation="MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLL FT IVASDVFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVSSVQQ FT ALRTTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPRVAAQVRVATESCIDAV FT FALISADSRLDPHRARMVAVGLVGISVDCARYWLDTNRPISKSDAVEGTVQFAWGGLSH FT VPLTRL" FT misc_feature complement(276245..276385) FT /note="Pfam match to entry PF00440 tetR, Bacterial FT regulatory proteins, tetR family, score 71.30, E-value FT 2.1e-17" FT RBS complement(276519..276523) FT /note="possible RBS" FT CDS 276701..277726 FT /transl_table=11 FT /gene="ML0816" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT 31.0 kDa protein Rv3207c or MTCY07D11.19 (285 aa) TR:O05859 FT (EMBL:Z95120) fasta scores: E(): 0, 80.6% id in 284 aa, and FT to Streptomyces coelicolor putative membrane protein FT SC2H12.28c (314 aa) TR:CAB94652 (EMBL:AL359215) fasta FT scores: E(): 1e-13, 30.2% id in 331 aa." FT /db_xref="GOA:Q9CCG9" FT /db_xref="InterPro:IPR006026" FT /db_xref="UniProtKB/TrEMBL:Q9CCG9" FT /protein_id="CAC30326.1" FT /translation="MSSPGPVGSPGRVPVLREEWRAPLRAQREPLARGEGRVRVNRGRS FT RRWRKQTRLGRFVSVFGWRAYALPFLMALTAVVLYQTVTGTNAPEPAASEPITEPPVIG FT AVGTAIMDVPPRGLAAFDANLPAGTLPDGGAFTEAGDKTWHVVPGTMPQISQSATKVFK FT YSIEIENGLDPTMFGGDGAFAQMVDQTLANPKGWTHNPQFAFTRIDTGMPDFRISLVSP FT LTIRAGCGYEFRLETSCYNPSFGPDRQARVLINEARWLRGALPFEGDVGSYRQYVINHE FT VGHAIGYVRHEPCDKQGGLAPVMMQQTFSTSNNDGAKFDPEWVKPDGKTCRFNPWPYPI FT A" FT RBS 277916..277920 FT /note="possible RBS" FT CDS 277930..279117 FT /transl_table=11 FT /gene="moeZ" FT /gene_synonym="ML0817" FT /product="probably involved in molybdopterin biosynthesis" FT /note="Similar to M. tuberculosis moeZ, Rv3206c, moeB FT homologue, TR:O05860 (EMBL:AL123456) (392 aa); Fasta score FT E(): 0, 86.4% identity in 391 aa overlap and to M. FT tuberculosis moeB, Rv3116, putative molybdopterin FT biosynthesis protein, TR:O05792 (EMBL:AL123456) (389 aa); FT Fasta score E(): 0, 57.8% identity in 384 aa overlap. FT Similar to many e.g. Arabidopsis thaliana cnx5, FT molybdopterin synthase sulphurylase, TR:Q9ZNW0 FT (EMBL:AF124160) (464 aa); Fasta score E(): 0, 34.5% FT identity in 406 aa overlap. Contains Pfam match to entry FT PF00581 Rhodanese, Rhodanese-like domain. Contains Pfam FT match to entry PF00899 ThiF_family, ThiF family." FT /db_xref="GOA:Q9CCG8" FT /db_xref="HSSP:1JWA" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CCG8" FT /protein_id="CAC30327.1" FT /translation="MSTSSTSLPPLVEPAGQLSRDEVIRYSRHLIIPDIGVDGQMRLKS FT ARVLVIGAGGLGAPVLLYLAAAGVGTIGIIDFDVVDESNLQRQIIHGVADVGRSKAQSA FT RDSIVAINPLVQVRLHEFRLESSNVVNLFKQYDLIVDGTDNFATRYLINDAAVLAKKPY FT VWGSLYRFEGQVSVFWEDAPDGLGLNYRDLYLEPPPPGMVPSCAEGGVLGIVCASIASV FT MGTEAIKLITGIGAPLLGRLMIYNALEMSYRRIRIHKDPSRPKITELTDYQQFCGVVSD FT DAAQVATGSIVTPRELRELLDSGKKLALIDVREPVEWDIVHIDGAQLIPRSLINSGEGL FT AKLPQDRMSVLYCKTGVRSAETLATVKKAGFSDAVHLQGGIVAWAKQVQPDMVIY" FT misc_feature 278059..278469 FT /note="Pfam match to entry PF00899 ThiF_family, ThiF FT family, score 220.20, E-value 3e-62" FT misc_feature 278806..279090 FT /note="Pfam match to entry PF00581 Rhodanese, FT Rhodanese-like domain, score 49.80, E-value 6.2e-11" FT CDS 279172..280065 FT /transl_table=11 FT /gene="ML0818" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3205c, hypothetical FT protein, TR:O05861 (EMBL:AL123456) (292 aa); Fasta score FT E(): 0, 87.3% identity in 291 aa overlap." FT /db_xref="InterPro:IPR013402" FT /db_xref="UniProtKB/TrEMBL:Q9CCG7" FT /protein_id="CAC30328.1" FT /translation="MRSPRSGSTRLTRVTVEPPPEHVLSAFGLTGVQPVPLGASWEGGW FT RCGEVVLSMVADNARAAWSARVRETLFVDGIRLARPVRSTDGRYVVSCWRANTFVAGTP FT EARHDEVVSAAVRLHEATGKLERPRFLTQGPTARWADVDIFIAADRAAWEGRPLQSVPS FT GVWAAPMTTDGQRSVDLINQLAGLRKPTRSPNQLVHGDLYGTMLFVGTAAPGITDITPY FT WRPASWAAGVVVVDALSWGEADDGLIERWNALPEWPQMLLRALMFRLAVHALHPRSTAE FT AFPGLARTAALVRLVL" FT CDS complement(280156..280444) FT /pseudo FT /transl_table=11 FT /gene="ML0819" FT /product="putative methyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3204 (Best blastx score 245)" FT CDS complement(280478..281131) FT /pseudo FT /transl_table=11 FT /gene="lipV" FT /gene_synonym="ML0820" FT /product="probable lipase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lipV (Best blastx score 236)" FT CDS 281793..284899 FT /pseudo FT /transl_table=11 FT /gene="ML0821" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3202c (Best blastx score 725)" FT CDS 284938..287898 FT /pseudo FT /transl_table=11 FT /gene="ML0822" FT /product="probable ATP-dependent DNA helicase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3201c (Best blastx score 510)" FT CDS 288026..289052 FT /pseudo FT /transl_table=11 FT /gene="ML0823" FT /product="putative potassium channel (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3200c (Best blastx score 571)" FT repeat_region 289017..289777 FT /note="Dispersed repeat, RLEP, copy 9" FT CDS complement(289783..290178) FT /transl_table=11 FT /gene="furB" FT /gene_synonym="ML0824" FT /product="putative ferric uptake regulatory protein" FT /note="Similar to Mycobacterium tuberculosis cosmid y27 fur FT or Rv2359 or MTCY27.21c TR:O05839 (EMBL:Z95208) (130 aa) FT fasta scores: E(): 0, 86.9% id in 130 aa, and to FT Escherichia coli ferric uptake regulation protein fur FT SW:FUR_ECOLI (P06975) (148 aa) fasta scores: E(): 2.1e-13, FT 37.2% id in 129 aa. Contains Pfam match to entry PF01475 FT FUR, Ferric uptake regulator family." FT /db_xref="GOA:Q9CCG6" FT /db_xref="HSSP:1MZB" FT /db_xref="InterPro:IPR002481" FT /db_xref="UniProtKB/TrEMBL:Q9CCG6" FT /protein_id="CAC30334.1" FT /translation="MMTGASVRSTRQRAAISTLLETVDDFRSAQELHNELRRRGNNISL FT TTVYRTLQSMAEAGMVDTLRTNTGESVYRRCSRQHHHHLVCRGCGSTIEVGDHEVEAWA FT AEVAAKHGFSDVSHTIEIFGTCSECRS" FT misc_feature complement(289810..290169) FT /note="Pfam match to entry PF01475 FUR, Ferric uptake FT regulator family, score 185.20, E-value 1e-51" FT CDS complement(290252..290674) FT /transl_table=11 FT /gene="ML0825" FT /product="putative ArsR-family transcriptional regulator" FT /note="Similar to Mycobacterium tuberculosis putative FT transcriptional regulator Rv2358 or MTCY27.22c TR:O05840 FT (EMBL:Z95208) (135 aa) fasta scores: E(): 0, 72.9% id in FT 140 aa. Contains a probable helix-turn-helix motif at aa FT 77-98 (Score 1179, SD +3.20) Contains Pfam match to entry FT PF01022 HTH_5, Bacterial regulatory protein, arsR family." FT /db_xref="GOA:Q9CCG5" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:Q9CCG5" FT /protein_id="CAC30335.1" FT /translation="MVTSPSTSTTVDLPSTTTDLSSGLVEGHEHGADGISRLADYPAPP FT PRETLDAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALGIPQPLVSQHLKILKGAG FT IVAGERSGREMLYRLADYHLTHIVVDAVAHAGVDAL" FT misc_feature complement(290273..290506) FT /note="Pfam match to entry PF01022 HTH_5, Bacterial FT regulatory protein, arsR family, score 79.00, E-value FT 1e-19" FT CDS 290841..292232 FT /transl_table=11 FT /gene="glyS" FT /gene_synonym="ML0826" FT /product="putative glycyl-tRNA synthase" FT /note="Similar to Mycobacterium tuberculosis glycyl-tRNA FT synthetase glyS or Rv2357c or MTCY27.23 or MTCY98.26 FT SW:SYG_MYCTU (O65932) (463 aa) fasta scores: E(): 0, 90.2% FT id in 459 aa and to Thermus aquaticus glycyl-tRNA FT synthetase glyS SW:SYG_THETH (P56206) (505 aa) fasta FT scores: E(): 0, 43.6% id in 512 aa. Contains Pfam match to FT entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, FT P, S and T). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00179 Aminoacyl-transfer RNA FT synthetases class-II signature 1." FT /db_xref="GOA:Q9CCG4" FT /db_xref="HSSP:1ATI" FT /db_xref="InterPro:IPR002315" FT /db_xref="UniProtKB/TrEMBL:Q9CCG4" FT /protein_id="CAC30336.1" FT /translation="MPCLVASVIDTVVNLAKRRGFVYPAGEIYGGTKSAWDYGPLGVEF FT KENIKRQWWRSVVTGREDVVGIDSSIILPRQVWVASGHLEIFHDPLVESLITHKRYRAD FT HLIEAYEAKHGQSPCNGLADIRDPDTGEPGQWTEPREFNLMLKTYLGPIETEEGLHYLR FT PETAQGIFINFANVVTTARRKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVE FT PSTARDWHQYWIDTRMQWYVELGIDPQNLRLFEHPKDKLSHYSDRTVDIEYKFGFVGNP FT WGELEGVANRTDFDLSTHARYSGVDLSFYDQVNDTRYTPYVIEPAAGLTRSFMAFLIDA FT YTEDEAPNTRGGMDKRALLRLDPRLAPIKAAVLPLFRHVDLSPKARDLAAELRKCWNSE FT FDDAGAIGRRYRRQDEVGTPFCVTVDFESLDDNAVTVRERDAMTQERVAMTNVADYLAV FT RLKGS" FT misc_feature 291090..292175 FT /note="Pfam match to entry PF00587 tRNA-synt_2b, tRNA FT synthetase class II (G, H, P, S and T), score 6.50, E-value FT 0.00073" FT misc_feature 291402..291425 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 291426..291488 FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT repeat_region complement(292403..293142) FT /note="740 bp repeat. 100% identical to region FT 3044255..3044994" FT CDS complement(293136..293417) FT /pseudo FT /transl_table=11 FT /gene="ML0827" FT /product="putative transposase (pseudogene)" FT /note="Possible pseudogene of a Tn3-type element FT transposase" FT CDS 294489..295339 FT /pseudo FT /transl_table=11 FT /gene="ML0828" FT /product="PPE-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis PPE-family FT protein (Best blastx score 102)" FT repeat_region complement(294996..295158) FT /note="163 bp repeat, 96% identical to region FT 754310..754472" FT CDS 295746..296267 FT /pseudo FT /transl_table=11 FT /gene="plcB" FT /gene_synonym="ML0829" FT /product="phospholipase C precursor (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis plcA, B or C FT (Best blastx score 175)" FT CDS complement(296296..298298) FT /pseudo FT /transl_table=11 FT /gene="ML0830" FT /product="precursor of probable membrane protein FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2345 (Best blastx score 503)" FT repeat_region 296591..296626 FT /note="18 copies of dinucleotide repeat, TA" FT CDS 298474..299763 FT /transl_table=11 FT /gene="dgt" FT /gene_synonym="ML0831" FT /product="putative deoxyguanosine triphosphate hydrolase" FT /note="Similar to Mycobacterium tuberculosis FT deoxyguanosinetriphosphate triphosphohydrolase dgt or FT Rv2344c or MTCY98.13c SW:DGTP_MYCTU (P95240) (431 aa) fasta FT scores: E(): 0, 83.8% id in 421 aa and to many hypothetical FT deoxyguanosine hydrolases. Contains Pfam match to entry FT PF01966 HD, HD domain." FT /db_xref="GOA:Q9CCG3" FT /db_xref="InterPro:IPR006674" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCG3" FT /protein_id="CAC30341.1" FT /translation="MTTKANTNQHDPYDDFDRQRRAHEAPKTAVLPGSEGQHRTEFARD FT RARVLHSAALRRLSDKTQVVGPHEGDTPRTRLTHSLEVAQIGRSMAVGLGCDLDLVELA FT GLAHDIGHPPYGHNGERALDEVAVGYGGFEGNAQNFRILTSLEPKVIDEQGCSVGLNLT FT RASLDAVTKYPWTRVGGLGHGRSKYGFYEEDRDPADWVRVYAPANRACLEAQVMDWADD FT VAYSVHDVEDGVVSQRIDLRVLADEYETAALAKLGEGEFSWVTADELMAAAHRLSELPV FT VAAVGKYDATLASSVALKRLTSELVGRFASVAIATTRAVAGPGPLVRYQADLQVPDLVR FT AEVAVLKILALQFIMSDPRHLEGQARQRERIHRVANWLYSGAPSTLDPVFVTAFTTAVD FT DNARWRVIVDQIASYTEGRLERIDAGQASP" FT misc_feature 298699..299151 FT /note="Pfam match to entry PF01966 HD, HD domain, score FT 6.80, E-value 0.048" FT CDS 299874..300327 FT /pseudo FT /transl_table=11 FT /gene="ML0832" FT /product="superoxide dismutase precursor (Cu-Zn) FT (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue sodC (Best blastx score 163)" FT CDS 300458..302386 FT /transl_table=11 FT /gene="dnaG" FT /gene_synonym="ML0833" FT /product="DNA primase" FT /note="EC_number=2.7.7.-" FT /note="Similar to Mycobacterium tuberculosis DNA primase FT SW:PRIM_MYCTU (P95239) (639 aa) fasta scores: E(): 0, 80.4% FT id in 642 aa, and to Mycobacterium smegmatis primase dnaG FT TR:O52200 (EMBL:AF027507) (636 aa) fasta scores: E(): 0, FT 76.2% id in 642 aa. Contains Pfam match to entry PF01751 FT Toprim, Toprim domain. Contains Pfam match to entry PF01807 FT zf-CHC2, CHC2 zinc finger." FT /db_xref="GOA:Q9CCG2" FT /db_xref="HSSP:1D0Q" FT /db_xref="InterPro:IPR002694" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCG2" FT /protein_id="CAC30343.1" FT /translation="MVGRIPDRDIAAIRERVCIEEVVGDYVQLRRAGADSLKGLCPFHN FT EKSPSFHVRPNHGHFHCFGCSEGGDVYAFIQKIEHVSFVEAVEMLADRIGHTINYFGTA FT TSVQRDRGSRSRLIAANAAAAAFYAAALESDEAAPARQYLMERNFDANAARHFGCGFAP FT SGWDSLTKYLISKGFEFTELEAAGLSRQGRRGPMDRFHRRLLWPILTLAGEVIGFGARR FT LFDDDPMEAKYVNTPETLLYKKSSVMFGIDLAKRDIVKGHQAVVVEGYTDVMAMHLAGV FT TTAVASCGTAFGDEHLAMLRRLIMDDNWYRGELIFVFDGDAAGQAAALKAFDGDQQVAG FT KSFVAVAADGMDPCDLRLSSGDQALRDLVACRKPMFEFAIRSLIPDGMVLDDDPQAKVD FT ALRRSVPLVARIRDYALRDEYARRLAGWTGWSDEGQVLARVREEANRRSVPERTRRRSV FT SVEQSPFMQPPGAPADQLAARPDPRDPTLWPQREALKSVLQYPVLAGPVFDTLTVESFT FT HPGYGAVRAAIDAAGGASAGITGAQWIDVVRQQTTSALIAGLINELGVESIQVDDEKLP FT RYIDGVLARLQEVWMGRQIAEVKSKLQRMSPIDQGDEYHELFGDLVAMEAYRRSLLEQA FT SGDDMTA" FT misc_feature 300566..300736 FT /note="Pfam match to entry PF01807 zf-CHC2, CHC2 zinc FT finger, score 130.30, E-value 3.6e-35" FT misc_feature 301241..301501 FT /note="Pfam match to entry PF01751 Toprim, Toprim domain, FT score 65.00, E-value 1.6e-15" FT CDS complement(302401..302703) FT /transl_table=11 FT /gene="ML0834" FT /product="conserved hypothetical protein" FT /note="Similar to Mycobacterium tuberculosis hypothetical FT protein Rv2342 or MTCY98.11 TR:P95238 (EMBL:Z83860) (85 aa) FT fasta scores: E(): 3e-21, 76.9% id in 78 aa and shows weak FT similarity to Streptomyces coelicolor putative secreted FT protein SCC24.32 TR:CAB86126 (EMBL:AL163003) (108 aa) fasta FT scores: E(): 0.035, 30.5% id in 95 aa." FT /db_xref="UniProtKB/TrEMBL:Q9CCG1" FT /protein_id="CAC30344.1" FT /translation="MRQDGASRTVVGGTALIRYVIVLGLGYVLGAKAGRRRYEQIVGIY FT RTLTGSPMAKSMIAEGRRKVANRISPDEGFVTLAEIDNQTTVIERSAEWRENGGN" FT tRNA 302844..302916 FT /gene="asnT" FT /note="tRNA Asn anticodon GTT, Cove score 78.91" FT CDS complement(302964..304727) FT /pseudo FT /transl_table=11 FT /gene="mez" FT /gene_synonym="ML0835" FT /product="probable malate oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT mez (Best blastx score 299)" FT CDS 305461..305727 FT /pseudo FT /transl_table=11 FT /gene="ML0836" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to bacterial FT hypothetical proteins e.g. Thermotoga maritima TM0911 FT TR:Q9X013 (EMBL:AE001755)" FT CDS 305882..306265 FT /transl_table=11 FT /gene="ML0837" FT /product="hypothetical protein" FT /note="Similar to part of Streptomyces coelicolor putative FT aldolase SCI8.29C TR:Q9RJ24 (EMBL:AL132644) (240 aa) fasta FT scores: E(): 0.001, 32.5% id in 120 aa." FT /db_xref="GOA:Q9CCG0" FT /db_xref="InterPro:IPR001303" FT /db_xref="UniProtKB/TrEMBL:Q9CCG0" FT /protein_id="CAC30347.1" FT /translation="MPDTTSNIAVRSGRTVVITGSGLAKVELTADDMVKVNIADPQIIS FT GIRCLSAGAIIHTGVFRASYTDAVVHIHLSYVMAQSLDVPSVLRFSGYELIKRLGIRRT FT IAIPVFGDHADISRVGIDIERHL" FT stem_loop complement(306929..306988) FT /note="60 bp palindrome" FT CDS complement(307670..308353) FT /transl_table=11 FT /gene="cysE" FT /gene_synonym="ML0838" FT /product="putative serine acetyltransferase" FT /EC_number="2.3.1.30" FT /note="Similar to Mycobacterium tuberculosis putative FT serine acetyltransferase cysE or Rv2335 or MTCY98.0031C FT TR:P95231 (EMBL:Z83860) (229 aa) fasta scores: E(): 0, FT 76.4% id in 229 aa, and to Bacillus subtilis serine FT acetyltransferase cysE or cysA SW:CYSE_BACSU (Q06750) (217 FT aa) fasta scores: E(): 0, 47.1% id in 204 aa. Previously FT sequenced as TR:O32979 (EMBL:Z98741). Contains 4 Pfam FT matches to entry PF00132 hexapep, Bacterial transferase FT hexapeptide (four repeats). Contains PS00101 FT Hexapeptide-repeat containing-transferases signature." FT /db_xref="GOA:O32979" FT /db_xref="InterPro:IPR018357" FT /db_xref="UniProtKB/TrEMBL:O32979" FT /protein_id="CAC30348.1" FT /translation="MFAAIRRDIQAARQRDPAQPTVLEVICCYPGVHAVWGHRISHWLW FT NRRARLAARAFAELTRILTGVDIHPGAVLGAGLFIDHATGVVIGETAEVGDDVTIFHGV FT TLGGTGRETGKRHPTIGDRVTIGAGAKVLGAIKIGEDSRIGANAVVVKEVPASAVAVGV FT PGQIISSDSPANGDDSVLPDFVGVSLQSLLTRVAKLEAEDGGSQTYRVIRLPEAGVWHG FT EDFSI" FT misc_feature complement(307892..307978) FT /note="PS00101 Hexapeptide-repeat containing-transferases FT signature" FT misc_feature complement(307898..307951) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 7.30, E-value FT 78" FT misc_feature complement(307952..308005) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 11.60, FT E-value 19" FT misc_feature complement(308030..308083) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 15.90, FT E-value 0.98" FT misc_feature complement(308126..308179) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 7.00, E-value FT 86" FT CDS complement(308356..309288) FT /transl_table=11 FT /gene="cysK" FT /gene_synonym="ML0839" FT /product="putative cysteine synthase" FT /EC_number="4.2.99.8" FT /note="Similar to Mycobacterium tuberculosis cysteine FT synthase A cysK or Rv2334 or MTCY98.03 SW:CYSK_MYCTU FT (P95230) (310 aa) fasta scores: E(): 0, 85.8% id in 310 aa, FT and to Spinacia oleracea cysteine synthase, chloroplast FT precursor cysK SW:CYSL_SPIOL (P32260) (383 aa) fasta FT scores: E(): 0, 59.2% id in 309 aa. Previously sequenced as FT SW:CYSK_MYCLE (O32978). Contains Pfam match to entry FT PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent FT enzyme. Contains PS00901 Cysteine synthase/cystathionine FT beta-synthase P-phosphate attachment site." FT /note="Similar to ML2396" FT /db_xref="GOA:O32978" FT /db_xref="HSSP:1OAS" FT /db_xref="InterPro:IPR001926" FT /db_xref="UniProtKB/Swiss-Prot:O32978" FT /protein_id="CAC30349.1" FT /translation="MSIAEDVTQLVGNTPLVRLRRVTEGALADVVAKLESFNPANSVKD FT RIGVAMIDTAEEAGLIKPDTVILEPTSGNTGIALAMVCAARGYHCVLTMPETMSIERRM FT LLRAYGAELILTPGADGMSGAIAKAEELAKSDKRYFIPQQFENPANPAIHAATTAEEVW FT RDTDGKVDIFVSGIGTGGTITGVARIIKERRPATQFVAVEPAASPVLSGGQKGPHPIQG FT IGAGFVPSVLVLDLVDEIVTVGNEEALDLARRLAKEEGLLVGISAGAAVCAALHVARRP FT ENTGKLIVVVLPDFGERYLSTMLFADLAN" FT misc_feature complement(308404..309270) FT /note="Pfam match to entry PF00291 S_T_dehydratase, FT Pyridoxal-phosphate dependent enzyme, score 447.00, E-value FT 1.6e-130" FT misc_feature complement(309136..309192) FT /note="PS00901 Cysteine synthase/cystathionine FT beta-synthase P-phosphate attachment site" FT CDS complement(309285..310589) FT /transl_table=11 FT /gene="ML0840" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O32977 FT (EMBL:Z98741)." FT /db_xref="UniProtKB/TrEMBL:O32977" FT /protein_id="CAC30350.1" FT /translation="MTVLSISSRALAQVVTCRRITVRPTTELTHMTRYRSGTYSHTVDT FT IIFADGTCARTDLIRLNPNLHAYSLDFTGIAPQHPSRYRLGTFSALPHLSAHSCEAEVD FT WILRHSFPMRSTTDLSQRIREAGYPLGPANISEHEAIAATQAAIWYLTNGLALDTRPRN FT VPVAVHRCPGPVITFEFDGEPQLGGYSAWVDAEAPVDLKLQKSSNGVVWQDVSGSQRTI FT PAGIGRHQQTLGVGSTLLASSHGRGGRGYRYYRLIATTDAASPTIDHVDFWLTGTRHYH FT NADRVVYLYNYLLAETSHVLHQTDEPDLVDTNAIAEPELVGPFQVRIPLMFNASDGHTL FT VNSYGYVIDDIIQPGTDFYLRQTAGKSTTTLTATTPHNVAGRVVTGVAIEGTPQRLTPI FT ALAIPTEMAIEFDISWEANEAEMFEEAEPLGDEDR" FT RBS complement(309296..309302) FT /note="possible RBS" FT RBS complement(310600..310606) FT /note="possible RBS" FT RBS 310962..310966 FT /note="possible RBS" FT CDS 310972..311895 FT /transl_table=11 FT /gene="ML0841" FT /product="major membrane protein I" FT /note="Similar to Mycobacterium paratuberculosis 35 kDa FT protein TR:Q9RAJ4 (EMBL:AJ250887) (307 aa) fasta scores: FT E(): 0, 92.2% id in 307 aa and to Mycobacterium avium major FT membrane protein I mmpI SW:MMP1_MYCAV (Q48899) (307 aa) FT fasta scores: E(): 0, 89.6% id in 308 aa. Previously FT sequenced as SW:MMP1_MYCLE (P46841)." FT /db_xref="GOA:P46841" FT /db_xref="UniProtKB/Swiss-Prot:P46841" FT /protein_id="CAC30351.1" FT /translation="MTSAQNESQALGDLAAGQLANATKTVPQLSTITPRWLLHLLNWVP FT VEAGVYRVNRVVNPERVAVKAEAGAGTEAPLPETFVDYETSPREYTLRTISTLLDIHTR FT VSDLYSSPHDQITQQLRLTIETIKERQECELVNSPEFGLLAQVTPEQTIRTFAGAPTPD FT DLDALITKVWKMPSFFLTHPQGIAAFGREATYRGVPPVVVSLFGAQFITWRGIPLIPSD FT KVPVQDGETKFILVRTGEERQGVVGLFQPGLVGEQAPGLSVRFTGINQAAIATYLVTLY FT TSLAVLTDDALAVLDNVAVDQFHEYK" XX SQ Sequence 312050 BP; 59627 A; 84708 C; 97050 G; 70665 T; 0 other; gcgtgatttg ttagcgatgt cctgtccgtg ttggcgctca tcgaaagcaa cccagttttg 60 ctcaatgaaa attgaccgct ttggcccttg ttcggggtag tgctatgtga tcgcttcctg 120 gggtttggat ccgtgtggtg tcgtcagtgt tgaccgtgat ggcggtgccc acaactgaga 180 cagttggcaa tggtcatggt ttggcctcgg ggtgcaacgc gctgttaagc gcatccctgc 240 tttgctggtg agcacgcatc cgatatggtg gacatcgatg tagaccacta tctcgttgtg 300 caacaatcga tctaaaaccg cagcgacgaa tagcgggttg cagaggtgct cagcactaca 360 cggctatgcc ggtatgcaag gtgaaaattg tcgatgattt caggtagtga tgagcaatca 420 cttcgaagag cgcggtgttg gcttcggaat cgggattgtg gaggggcccg cattcgtcga 480 tgatcagtaa ccgtggaccg gacaagaacc gcatgcgagt ggtccactgg ccttcgagtg 540 caacctttgt ggcaacgctt ggtcacacca tcgacaggcg gtggtgaagt agacgcgatg 600 atcggtctgg actgccgcac gggccaactc ggtggccagc atagtcttgc cggtacccgg 660 tggcacgaca aaaatcacat tgccgatgtt gtcgaggagc cgtaacgaag ccagctcgcg 720 gatgagttct caagcaacgc cgggctgggc gatgaaatcg aactcatcga aacggaagtc 780 ggttggcaga taaaccaact actaatagct gttcgagcat ggccactgta gacagatcct 840 gatacagtcc gtcatccaac atccctgtct gcacctcggt cgccgcggaa gccgaagtac 900 gtgcagataa tcgcgtaggg ggaggcctgg ctattgtggt ggtgctcata ggttctgtcc 960 ctgtattatt ggtcggggtg attgcggtgt agcgcgacat cggtcactac ctgctcagct 1020 gggcagcgtc tggttgttct gtcggatccg gtcggccgtg gccagctcct gcgcggtggt 1080 tcggtgtcgg tgtttgcgtc gacatctagg cctgtcggac aattggtcag cataaccttc 1140 ttcggggcta ctacatgata agcggcgcac accaccgtgc cggcgctatc aggtgtgcgg 1200 tggtgccggg ccagcatcac cccggtgtag gtgaccacgt ccaacttcaa ctcaccgcac 1260 agttgacaaa ccagcagacg tcggcctgcg ttactcgggt ggcatcgaat agcttttggc 1320 gcggaacgaa atccgtgcct ggttgtgcat cgtgcgccac cagtattgag cgatcatcgc 1380 gaccaccgcg cccttgcacc aggcgtgata ggcgtgggca cacgtcaata ccgaccgtat 1440 agttacgggt gattggctca aacaacatct aaagtcggct actgtgcggc taggccaccg 1500 tgagcatcca gtcaaagtgc caccatgtcc aagctctccg ccagatgcgg ctgattggtc 1560 aactcagtta gccgcgtccc taatgcgaca aacgtcccaa tcagcacact ggccgtttta 1620 cctcagccct cacaaggccg caggatcgga aaatgccacc caatcccatt ggttttcagc 1680 acccaatgga tgctcgatca ccgcccgatc gggccttcgg atctgcttgt ataacggcgc 1740 agcgggcaca acgctcgttt gcgaagcact cgagtaaaca ccgaatacag tctagtgcaa 1800 cccagtgtgg tgacctcgtt gaataacgtg gtagtcgcac agatgcggat cggctgccaa 1860 tcgcagctga cgttactcga catactgagc caacgggccc agcgtccagc gggcttgcca 1920 gtggaaatct gttcactagc cagatatccg cgcaccgtga cctgggttac tcctaaatgg 1980 taaatggtgg gcgatcgggt tgactgtcca gccctgttta tttagttcct gtacttacac 2040 aacgaactct catgcgaaca tccgagacat gttcccttct aattactttc gtaatccaac 2100 gctcacagcc aagactgggt ctacctacaa ccagcggatt gcaaacggcg agtcgcctct 2160 aggggatagt cactttcgat gagtaggatt gtcgctttat aaattgagcg gcgggaggcc 2220 ttgagtacag ccgctgctat accatgcacc gagtacggcc tacacattgc ccatttcctg 2280 acctgcgtgc atgaccgatt cctaatctat cgtcctgata cacctcactg actacaccgg 2340 tacgccacca ctgcaagtag cttcgtgccc ctacaacatt actttcggaa atttcagcca 2400 cacaatacgg ctgttgaatt gtttcttggt ttcgctggag gctttttgta cagggagagg 2460 gtaagtatgg atggcatcac agtggaagta ctcgcgggag ttgtgggagc ggcaacgagg 2520 atagcgggag aagtcaggtg ggctccggtg gtagccagag gcgcgattag gccgagcgtg 2580 agcgtgaagt gcaagaattg aagcttgtca acgagattct gcgaatagcg aacgcgtttt 2640 tcaccgcggc ggaagtcgat cgccgactgc ggtgatcctt tcgcgcgcaa ttctttgcag 2700 agtacatcaa tgtccaccgc gaagaatgcg ggtcgatcca atctgtcatg tacatgtttg 2760 agcaggctga cgtgcaggtc cccccgtcta cctactacac cgtcaagcag cagggttttg 2820 tgcgggcagc cgatcttacc gacacgtacg acggcaagat cctgtttgat ctgtggatgg 2880 ctaacctacc gatcttactg tgtgcacagg ctttagcccg ccactacaca cgcaggtcac 2940 agttgaggtc cagacagggc gacacggctg atgtgtatcg ccggtattga cgatgtaggc 3000 tgcaataagt gcagcattcg tacgactgag tacgacaagt cttcgccgcc gcagcatccc 3060 gaccggctcg atcgttcctg ctcaatgctg tcattacccg gatcagtggc aggtaaggga 3120 ttgcacatat gtgtggacgc tgcaaagggt gtgccatacc acgttttgtg tggacgtgtt 3180 ctcccacccc atcctgggct ggcaggtgat gaccagcaag accgcgggtg cttggtcaca 3240 tcggtgcttg agcagacgct actcaccccc tattgcacat agctccattc tctataaccg 3300 atttgattca tcacttggac gcgggatcaa tatacgtcga tcgcgttcac cgaggcgctg 3360 cacgaggccg gtatcgccgg atccatcagc agtgtcggcg acgctttgga caacgtgttt 3420 atggattctg ctatagggac ggtacaaatc tgaattaatc gaccaacatg cgaccttcac 3480 cggtcgcgtc gaactggaac gggaaaccac ctcctgggtg cactagtaca acacgatcga 3540 gactccacct catcaatatc aatccaatac cgaccaccag tcgcatacga acagcgctac 3600 cagcagacag ccaccccgac cgaagtgaca tgaaccaata atctccgaca gctccagaac 3660 agttccttcg ccgcataaca ccaacgacct acttcgaagt tcctgctgcc tgtttacaca 3720 aaaattgagt taacctcggt ttttatattt tgagcggagc cgagctattc tggttacatc 3780 gcgcatctga tcactgaaat gggctgtgct gcggaaaaag atcggcgttg aaagacatgc 3840 cagatcacat cgaaggtagc cagaattttt ggttactcca gaatcgtatt aattctgcgt 3900 ctacatcagt tcagaaggct ttatggagca gtaactttag cttagcccgc tacgtaaaac 3960 tcgagggaat tgtaagcgaa tgacaggcgc gttcgttgac cggctctgac attacctagt 4020 gcagtcaacg cagggtgagg agggagcttc ctcggcctcg gtggcgtagt cggtcactgc 4080 gcctacggtt tcgtggactt caagacccga aatgaattac cgccaagctt cccaagcgat 4140 atggtgcgct gctggatagt tgtgcgcaat tccttgcttt gcccggtccg gacacgcccg 4200 ctctgcagat cgagatcatt tttcccggcg acaccatggt aaaacacgac ccggcccggg 4260 cttacacgcc gcgtgacggt cctacggggt cgatatgtgc gtttggtaac cagcactccg 4320 tagggcgctg tcacggagga actctaatcg gacactgacg agcttggcct ggatgcagtg 4380 gtggggatgc gatcacgacc aatccttctg acgaatagga cgaccgtgtg gtggaattct 4440 tcatcgtgat ggtaacatcc gggacacagc tggacatgat ttcttgcata tcgtggctac 4500 gaacacagta cgcaatctgg gggccgaatc ccctgacggg gactggtccg cggtgtcgac 4560 ggccgaacat cttatcaatt acgttggcga attgggttgc gaggacgact gggcgggttg 4620 agatttgtat atcggtgccg gggttgtcgt tcatgtcgtc gtaccggtgc cgtggtgcgt 4680 gatgacgatg cttgcttaac ccgagttggt ggagggatcc gttcgtgctc aagctcattg 4740 ctcgagtcgg gtgcaagcag ttcggttcgc tgggttaatt tgcttgtttg ggcagctatg 4800 ctgaggtggt catccccaac atgccgtgca gcggtgaccc ggttcgcatc gaacgtgtca 4860 aaccacgcca gggcgcgctt gcaacgacaa tcgagaggat ggctgccacg ctattcatgg 4920 tagcgtaggc tagctcggtc aggtcatgtt gcagcagaag cgtatcgagc atcgaagcct 4980 acgcctttag tgctaaccgg cgtttgcccc agtccggtta tgcgtgtctg gggttgtctt 5040 gatttggcgg gtgaaggccg tgaacggcgt gccggtaggc cgtatgacct tgagccgtgg 5100 ttggttgact ggctgttgca tcttagttgg gcatccatca cttcgccgac cacaccgcca 5160 ctgcaagcag cttttcgtaa ttacaagatt gctctcgaaa ccttcagtcg cacaaaataa 5220 ttcgattcct aacaccaact acctaacctg gcatgttaaa cttgactcaa caatttagct 5280 tcgctgagac tagctaagct agcttagaat ctgctaagat agctgtaatg taacggtaac 5340 actaccacga catgggtggt gtccaattcc ggcctctagg cgaatcttga acgccttggc 5400 ctcaaccgcc tccgtgtctc ttagcgaaac aatcggcaac gacaatcggt gaatgctaat 5460 ttatccgcga ttctcgacta ctcccgatta cgggtgccct tgaacgactg ctcttcactc 5520 gtatagatat agatcatcca gacagacgat ggtgtcaact ttcaatcgat tttccattgc 5580 cacgtcttgg aaaaagcgag tgtacacccg ttattccttc acgattaccg ggtcaccaat 5640 gttaactgtg ttgtagtacc attctgcgtc ggcagggctt aagctaatgc agccgtggct 5700 ggtgttatca aaacccattg actgcaccgc ccacggagcc gaatggatgt agaggccacg 5760 gctgctgata cggacggcgt aatccaccga gagcctgtac ccctcgggat cgtcgacagg 5820 tatgccgaca ctactcgaat ccataatcac cgagcgatcc ttggacatga cggtatactt 5880 accggtaggt gtcgggaatt ctgtcttacc catcgaggcc ggcatcaccc cttcttctcc 5940 ccagtggggc cgatggtggg gtgaaggcag tggagggggt gtctccgcct cgactccgtc 6000 gatcgtcacc gtgaacgtgt gattcgagat atccgcaata ccgagaatgg caggacccgt 6060 tttgaagttg gtggacaggt tgcccaccgt gagtgcgatc gtgctgtgct ctggccaata 6120 gcggtcagga acccactgca caactttgct gtcgagccag tcaaacttgc cgttcatcgc 6180 tggcgccgag cgcactttaa gggaaagctc ggtcgcctta cggttagtga cgggtgcgcc 6240 gaatgtcact accacggggt gcgccacacc caccaccgcg tcccgtgtag gtagaattga 6300 cgtgatggcg aagccatgcg catggttcac cgccgctagg cttacacgca ccggtcccgc 6360 gatcaccgtc gccgcgatcc cgatcaccac aagaacacct cgaattgctg cccgcataat 6420 tcccatcacc tttgagatga ccaaaatgtt gttgatgttg gcgatggtag gggtccatgc 6480 cgagtgagcg ggtacgcacg cgctagatag cttggtcaag tctcggtcaa gttttagttg 6540 cgcgttcagc acctggggga gatgctcgta ttccgctgcc gcgactcggt atccagctgt 6600 gttgtatcgg catggtgacc gagaagttga tatgtgttca gcggctgttt gcagacaccg 6660 gcccccagga ttagcggcgg acagtctcgg tcgtatgttc tatatatagt tatatgagtt 6720 atcgtatatt ctatatttat atgagttata tgcgtccatc gacgcttgtt aggcgtagct 6780 gctgcagtgt gacatgctca accggtccat gacttcggct acctgtcatt gatctagggt 6840 gacggcgagc agttcattag ccgattgaag acgacaaggg agagaccagt gacggtccgc 6900 gtgggcatta acggcttcgg ccgcatcgga cgcaacttct accgggcgtt attggcccaa 6960 caggaacatg gtattgccga cgtgcaagta gtcgccatca acgacatcac cgacaacagc 7020 acgctggcgt acctgctcaa attcgactcc atcctgggcc ggctgccaca cgatgttagc 7080 ctcgaggaag aggatacaat cgtggttggc tccgagaaaa tcaaggctct tgcggttcga 7140 gaaggtccag cggcattgcc gtggcatgcc ttcggcgtcg acgttgtcgt cgagtcgacc 7200 ggcttgttca ccaacgcggc caaggccaaa gggcacttgg aggccggcgc caagaaagtg 7260 atcgtttcgg cacctgccac tgatcccgat atcaccatcg tgttcggggt caacgacgac 7320 aagtacgacg gcagccagaa catcatctcc aatgcgtcgt gtacgacgaa ttgccttgca 7380 ccgctggcga aagtgctgca cgaccaattc ggcatcgtta agggtttgat gaccaccgtc 7440 cacgcgtaca ctcaagacca gaacctgcag gatggaccgc attctgacct gcgtcgtgcc 7500 cgcgctgccg cgctgaacgt tgtgccgacc tctaccggtg cggccaaggc gatcggcctg 7560 gtgatgcctg agcttaaggg taagcttgac ggttacgcac tgcgggtgcc gatccctacc 7620 ggctcggtta ccgacctgac agccgacttg tccaagtgcg tcagtgtcaa tgagatcaac 7680 gcggtgtttc aggacgccgc tgagggtcgg cttaaaggca tcctgaagta cgttgatgcc 7740 ccgatcgtct ctagcgacat cgtcaccgac ccgcacagtt cgatcttcga ctccggcctt 7800 accaaagtta tcgccagcca ggccaaggtg gtgtcctggt acgataacga gtggggctac 7860 tccaaccgtc tggttgatct ggtcggcctg gttggcaagt cactttagcc gtgcgcattc 7920 ctaatcttaa agatcttctt gaggaaggtg tttctggtcg ctgcgtgttg gtgcgctgcg 7980 atctgaacgt cccgctgggg gatgatggcg ccatcaccga cctcggtcgg gtcaccgcgt 8040 cggtgcctac gttgaaagcg ctgcttgagg ccggagccaa gattgtggtt gccgcccatc 8100 tgggccgccc caagaacggg ccagacccaa agctgtcact ggagccggtc gccgcggcgc 8160 tcggtgagca gctgggccaa aacgtccagt tggtctgcag caccgatcgt tcccctgtcg 8220 ggggtgatgc gctcgcctgt gttgagaggc tgaccgacgg cgacctccta ctgctgcaga 8280 acatccgctt cgatccgcgc gagaccagca aagtcgacga cgaacgactc gctctggcca 8340 agcaattggt tgaattggtc gggtcagcag gagcttttgt ttcggatgga ttcggtgtgg 8400 tgcatcgcag gcaggcttcg gtgtatgacg tcgctacgct attgccgcac tacgccggca 8460 tactggttgc tgacgagata aggatactcg agcaattgac tagttcggcc aaacgcccct 8520 acgcagtggt gctcggcggg tcgaaggtat ccgacaagct cggcgtcatc gagtcgctgg 8580 cgacaaaagc cgatagcatc gtactcggag gtggaatgtg ctttacattt cttgctgcac 8640 aaggattttc agtaggtaaa tcgttattgg aaaccgagat gatcgagacc tgtcgtagtc 8700 tgttggacac ctacgctgac gtgcttcggc ttcctatgga cattgtggtg acagagaagt 8760 tcgtcgctga ttcgccgccg cagaccgtcg ccgccgacgc tatcccagat ggattgatgg 8820 gactggatat cgggccggaa tcggtcaagc ggttcgctac gttgttatcc aacgcctcga 8880 ccattttctg gaacggaccg atgggcgtgt tcgaattccc tgcgtacgcc gcgggcacca 8940 gaggtgttgc tgaagcaatc gtggctgtta ctggcaaggg agctttcagc gtggtcggcg 9000 gcggtgactc tgcggctgcg atgcgggcgc tcagcctacc cgaaggcagt gtctcgcacc 9060 tttccaccgg tggcggcgcg tcgttggaat accttgaggg caagacgcta cccgggatcg 9120 aggtactagg tcgtgagcag ccaaggggag gagactcgtg agccgcaagt cgctcatcgc 9180 cggcaactgg aagatgaacc tgaatcattt cgaggcgatt gcgttggtgc aaaaaatcgc 9240 tttttcattg ccggacaagt attatgacaa ggttgatgtc acagttcttc cgccattcac 9300 tgacctgcgt agcgtgcaaa ccctggtcga tggcgataag ttgcgattga cctatggtgc 9360 ccaggatctt tcgcaacatg acctaggcgc ctacactgga gacatcagtg gggccttctt 9420 ggctaagttg ggctgtagct tcgtgctggt ggggcactct gagcggcgca cctaccacga 9480 cgaaggtgac gcgctggtgg ccgcgaagac ggctgcggcg ctcaaaaaca gcttgactcc 9540 gatcgtgtgc atcggcgagt acctcgagat ccgagaggtg ggtgaacacg tcagccactg 9600 ccagaaccag ctacgcggct cgctggctgg gctgtcgcct gaacagatcg gcaatgtcgt 9660 gatcgtttat gaaccggtct gggcgatcgg gactgggcgg gtggctagtg cagccgacgc 9720 ccaagaggtg tgcgaggcga tccgaaaaga gctgggtgcg ctggcatcac cgcaggtggc 9780 cgaaaccgtt cgggtgcttt atggtggctc gttgaacgcc aaaaacattg gcgatatcgt 9840 cgcccagcaa gacgtcgatg gtggtctggt tgggggagcg tcgctggacg gggcgcaatt 9900 cgcgacgctc gcggtcatcg ccgccggtgg gcctcttccc tagggaagcc ctcggggcgt 9960 cttgcactga cttggtgata ggttatgctg cagactttag ccgtagcgtt agctcagtgc 10020 tgtgggtggc taattcgcta tgggttcagt gtgcctgtcg ggtgggtgtg gtggccactg 10080 tggcgttgat cgcgggcatc ggtgtgctgt cagcgatctt tcaggttgtc gtgctggtgt 10140 tcctaggcgc gttctgcggc gttagcctgg ttgctaccgg gttctaccgc gaccagtggt 10200 gaccctacat atacccaggt tcgcacggta ttcgacgatg cgatcgttgc gatttgctag 10260 tacggcaacc agattcaagc gtgcatggtc ggtatcggtc gagttggcgg tggtggatgc 10320 cggtcgggac tctgggttgg tggagttggt ggatgcgctc agcctagaag ttggcgcgcc 10380 gggggatgcc gtgctagcga ctcgccgact gtcggtgttg atttgtgccg ctagcttccc 10440 ataccgtcct gttcaacagc gtgcgaatca gactttcctg gccgtggcca ccggcattat 10500 tatgcgcgat gcgtgaaagc tctccactcg ttttggctgc tgttgaccac cgccgtaatg 10560 gtgtggtcag ggtatgcttc ggtgttcgtc cgtacggttc attggtcttc agcacggtga 10620 ttggtgcgtt gctgtgactg attgctggcg gtttgcgctg ctagcctgct ttggtggtcg 10680 caaccgtgct ggcgctgagt tttgtcgtgc tatcggtgcc gaaactgtat ggtttcggcg 10740 ttattgtaat cacttccgcg gcgttgttgt cgcaatcgat ctgccttgcg tatccggtag 10800 cgcccgcggt gtgcctagta gacatgctaa tcagcactgt ggtggttgtg tgtcgtatac 10860 ctgttgtggc cgggagatcg gtggttgcct gaatcgcccg ggcttggtgc ggcccggagc 10920 tattctcgtc gaggcggtca aatcatccgg tcaatgctta tgctagcaaa cgcctatgtt 10980 agcaattgtc ccgcgactac gtctattggc ttgcgcatca ggtttgtgcc actgtcgagg 11040 ccgcggtgtt ggagcctctg gcaactggca gtgagttcca catgctgagc agattatttc 11100 ggctaccatt gaactggagg acgctgtgta cgcgatcagt tcggcagtgt acgccgggtc 11160 gggatccgac cacgctgatc aatgaggtac agcgtcggct gaaccgcttc gatcagagac 11220 tgccgtggcg cttaagttaa gcggccgccg gaacgcgtgc tcccaccgcc aggtgcccgc 11280 actatgcgga ccgtcaggat ccgggctagg cgcaccgggt gggggtgtgc tactatgatg 11340 caattaggaa gggatgtcgt gcagtggctc tgggtttggc cgctgtttca acactatatc 11400 ggtaccagtc caccggatca catcagattt cgtgttatga cccgatgtta gggtgaggta 11460 ggatatgcat ctctccgatg ctcgtagcgg aaattaaacg aaaatgcagt atagctgtgc 11520 tgtgtgtaca tcggaagcta atgtgttgtc tccgctggaa tgatcggtcg gcattattgg 11580 tcactggcag cagtactgga aaaaccggca tcgccgtaac ctcggcaacg gcacacggtg 11640 accttttggt cgagctcggc ccgctcgtcg gtggagtaat ccttgaggcc gcgggtacgg 11700 gggctggatg gcgtctggtg tcaatatctt gcaggacgtg ttcgcggtca tcgtcgaggt 11760 tctgttgctt tcggtcggta ccgggaacgc gaggaccgcg gaagactggc ccggccttgc 11820 tgtactgtcg gccggactcg tcgctgtgct gacgctgctg atccacgagc agcaagagga 11880 ctgggtgtgc cagcctgtga ctcgactatg ctggggccgt tcgacggtag acaggtagtc 11940 tagttgacca tggagttggc cctgcagatc accctggttg tcaccagcat cctcgtagtg 12000 ttgttagtac ttttgcaccg tgcgaagggt ggtggcctgt cgacgttgtt cggcggtggc 12060 gtgcaatcca gtctgtccgg gtcgacggtg gtggagaaga acctggaccg gttgacgctg 12120 ttcgtcaccg gaatctggct ggtatccatt atcggcgtag ccctgctaac taaataccgt 12180 tagcactgtt acttcaagta gatccccgca cacatggttg agttttccga tgctatactg 12240 gaaccgatcg gtgctgtcca gcggactcga gtcggtcgcg aggcgactga acctatgcgg 12300 gccgacatca ggctattggg taccattctt ggtgatactc tgcgtgagca gaacggtgat 12360 gaggtattcg atctcgtcga acgagtccgg gtcgagtcgt tccgggtgcg gcgttctgag 12420 attgatcggg ccgatatggc gcgtatgttc tctggtctcg acattcacct ggccatcccg 12480 atcatccggg cgtttagcca tttcgcattg ttggccaacg ttgccgagga catccaccgg 12540 gagcgtcggc gccatattca cctcgacgcc ggcgagccac tgcgggatag cagtttagcg 12600 gccacttacg cgaaacttga tctggcaaaa ctagattcgg ccaccgtggc agatgccctt 12660 actggtgcag tggtctcgcc ggtgattact gcgcatccca ccgagacccg tcggcgtacc 12720 gtatttgtta cccaacgccg gattaccgag ttgatgcggc tgcacgcgga gggacacacc 12780 gaaaccgccg atggccgcag cattgagcgt gaattgcgcc gtcaaattct cacgctgtgg 12840 cagacggcat tgattcggtt ggcgcgattg cagatctccg acgagatcga cgtagggctg 12900 cgatattact ctgccgcgct tttccatgtg attccgcagg tgaattccga ggtgcgcaac 12960 gcgttgcgtg cccggtggcc cgacgccgag ctgctgtccg gccctatact gcaacccgga 13020 tcgtggatcg gtggtgaccg ggacggaaac ccgaacgtga ctgccgacgt ggtgcggcga 13080 gcgaccggca gcgctgccta caccgtggtg gcgcactatt tggctgaact cacccacctc 13140 gagcaggagc tgtcgatgtc ggcgcgactg ataaccgtca cccctgagct ggccacgctg 13200 gccgctagct gtcaggacgc ggcctgtgcc gacgagccgt accggcgggc attgcgggtg 13260 atccgcggtc gattgtcctc gactgccgcc cacatcctgg atcagcagcc acccaaccag 13320 cttggtctgg gtttgccacc gtattcgacg ccagccgaac tatgtgccga tctggacacc 13380 atcgaagcct ccctgtgcac gcacggcgcc gcgttgttag ccgacgatcg gttggcgctg 13440 ttgcgagaag gtgttggagt ctttgggttt cacttgtgcg gtctggatat gcggcaaaat 13500 tccgacgtgc acgaagaggt ggtcgctgag ctgttggcgt gggccgggat gcaccaggac 13560 tacagttcgt tgcccgaaga tcaaagagtc aagctgctgg tggccgaact cggtaaccgc 13620 cgcccgttgg tcggggatcg tgcgcaatta tccgatttgg cgcgcggcga gctggccgtt 13680 cttgcggccg ctgcccacgc cgttgagctc tacggatcgg ccgcggtgcc caactacatc 13740 atctcgatgt gtcagtctgt gtcggatgtc ctggaggtcg cgatcctctt gaaggagact 13800 ggcctgttag acgcctccgg gtcgcagccg tactgtccgg tgggcatctc gccgctgttc 13860 gagacgatcg acgatctgca caacggggcg gccattctgc acgcgatgct ggaacttccg 13920 ctatatcgaa cgctggtggc tgctcgcggt aactggcagg aagtgatgct cggctactcc 13980 gattccaaca aagatggcgg ctatctggcc gccaactggg cggtttaccg cgccgagctc 14040 gctctggtag acgtggcccg caaaaccgga atccgtttgc gacttttcca tggtcgtggc 14100 ggcactgtcg gacgtggcgg cggtcctagc tatcaagcta ttctggcgca acccccgggg 14160 gcggtaaacg gctcgttgcg tctcaccgag caaggcgagg tcatagccgc caaatacgcc 14220 gaaccgcaaa tagcacgacg aaacctagag agtttggtgg ccgcgaccct agaatcaact 14280 ctcttggatg ttgaaggctt aggcgatgcg gctgaatctg cttacgccat actcgatgaa 14340 gtagccggcc tcgcgcggcg atcctacgct gaattagtca acacaccggg tttcgttgac 14400 tatttccaag cttccacgcc ggtcagcgag atcggatcgt tgaacattgg caaccgaccg 14460 acatcacgta agcctaccac gtcgatcgcg gatcttcgtg ctattccgtg ggtactggca 14520 tggagccaat cgcgagtcat gctcccaggt tggtatggca ccggatcggc gtttcagcag 14580 tgggttgcgg ctggacccga aagtgaatca cagcgggtag aaatgctgca tgacctctat 14640 cagcgttggc cgttctttcg aagtgtgctg tcgaacatgg cgcaggtact ggccaaaagt 14700 gatctgggcc tggcggcccg ctatgctgag ctggtggtcg acgaagcctt gcggcgcaga 14760 gtgtttgaca agatcgccga cgagcatcgg cgaaccattg ccatccacaa gctcattacg 14820 ggtcatgacg atctgcttgc tgacaacccg gctctggcgc gttcggtgtt caaccgcttc 14880 ccgtatctgg agccgttaaa ccaccttcag gtggagctat tgcgccgcta ccgctcgggt 14940 cacgacgacg aaatggtgca acgcggcatc cttttgacaa tgaacggatt ggccagcgcg 15000 ctacgtaaca gcggctaacc cggggcgagg ctcgggatcg gggggaggcg acatcatcag 15060 gcctcggata gctggctgtg ctatttgcat tgcatggtcc gatttcggag cctatctagc 15120 acaccacgga ccggcgtatt cggtggctga taaccgcgac agcatcatct ctgtagataa 15180 tcgccttcgc tccagtctgc tgcgcacggt tctgtcagcc atgaaggtca ttatgacgcc 15240 actagccagg aatcttggct gcggcttctt cgtccagcag ccagagtgtg gtttcaagcc 15300 cgacagctcc ggcggccggt attgaggcag agggagcgcc acccatggcg gctgccactg 15360 cgtcggcctt tgccgtcccg gaaaccatca gccatacctc acgagaacgt tgaatggcat 15420 taagtgtcaa ggtgattcgt tctggaggtg gttttggaga gttcctgact ccgaccacca 15480 tacgactggt ctcgcgcaca gctacggtat ttgggaacag cgaattgatg tgtccttcgg 15540 gtcccatgcc catcaggtgc acatcaaaat tcggggtggg ataaccgggt gcggcgtagg 15600 cagccagcag ctgttcgtaa gctagtgccg ctgcttctag atcgttgccg aattcaccgt 15660 cgcccgcagg catcgggtgc acctggctgg gcgggatgtc tatgtgatcg agcaacgcta 15720 cacgtgcctg tttctcgttg cgctcgtcgt cgtctttggg tacgtagcgc tcgtcgcccc 15780 agaatagatg caccctagac caatcgatct gctgtccacg tgtagctaaa tcccgcagta 15840 gtccaatgcc gctgctacca ccggtcagca caatcagtgc cctttctctg gcagccacgg 15900 cggattggat ggtgctggca agtcgttttc cggcggctcc gaccatggtc ttgctgtctg 15960 aaaagatctc tacactggcg ctcacaggta ctgaaccttt tcaatgcctt cgaaggcatt 16020 gaagtagaac ttgtcgggat ccagtcgtcg cagattttcg gctaggaact cctcggcttc 16080 cctgcgcgcc ccagggaact agtgcatctg gtttcacggt tcggatcagg gtagaggtca 16140 cccaagtctg aggtcggctt aagacgatgg tttcgctatt gcgtatcagt tcgaccttca 16200 gatcggcgac cgctcggcgc aacggtctgt tgatccggtt ggctaaccag ccggccagaa 16260 cgtcgagcgc gggttcggtc ttcatgccgg aaaccagtgc caaatcgatc ggctcgtgag 16320 gtggcaggtt gaccgcggag gtcagcagag cacgccaata ggttattagg tcccatgcca 16380 ggtgggtgtc gtcggcggtg taatcggata gccggctctt gatggttgcc agcgggtcga 16440 tactgttggt ggcgttggtg atacgctgaa ttgccaactt gcccagggag tcttggccgg 16500 acatcgttgg ggcgatgttc ggccaccagg ccaccatcgg gatgtcaggg agcagtatcg 16560 agataacgac gctgtgggcg taaacagcaa gagttctaga caccaccacc ccggcgcctg 16620 tatcggcacc cacccacagt tgtgcatcca agcgcgcttt attcgcgtac gaattgaccc 16680 tcatcgcgat gatgattcgg ttgggatact tgtggctggc tccgttggcg gcctcgatag 16740 attctttgag catggctttg ctgtacggcg tgatgaccag cgtaagcact cgactcatcg 16800 tgatggcgcc gatcctttcg cagagctcgt ctagtttcta tattgaccac tgtggtggtg 16860 tcgggaaaat caacgatcat tttgtgttgt tcctcaccat tgcttcgttc tgcatcgtcg 16920 ctgccattcc cggctagggc gctatagtat ctcgaaggat aattctggac cctaggttcc 16980 tatatcgggc agatcgggct tgccgtgtgt ccacccaatc ggcaagggct gggtcgagtg 17040 tttcccaagc taaattcgac ctccgcattg accggaaaca ggtacggcca gctaagcaac 17100 acatcaagga tcagttgctc gtcggtctcc ggtgtatcct aggcgattgg cgagtagttc 17160 gtcgtccatt cggcgtcgtt gacttccatc gagctgtccg ggactttgga gtttaaccgc 17220 aaggtaatcc cttcgccggg ctgtacgtgg atgaccaaag cgttggcgca gagctcgtcg 17280 gtatggtggc gttgcaaagg atgatgcggc ccgcgtttga agaccagagc gatttcggtc 17340 accctgtgac ctagtcgttt cccggctcgt aggtacaata gcaccttggc tcaacaccga 17400 gtatcaactt cgagcttgat agcggcgaag ctctgggtgt tggagtccgt ggcgaactcg 17460 tcctcgtcga ccagcctgac cacttttcgc cgccttgcca gccggcggcg tattggccgt 17520 ggccgcagtt gatggtaccg ttgaacggga cggtgaggtg acccgccgac agcaatttaa 17580 tcatttcagc ttgcaaccaa gctggattga agctgactgg cttttccatc gcgatcaacg 17640 tcagcaggtg catcagatga ttctggatga catcgtggtc ctcactaatg ccgtcgtagt 17700 aaccggctcg gtaactaagt tcttatgtct tcagccacgg tgatctgcac gtgtgcgttc 17760 cagataggaa tccacagttg attggcgaat cggagcgcca agatgttctg taccgtttct 17820 ttgcccaggt agtggtcgat accgaaaaca gcttcttccg ggaagactgt gttgccagac 17880 ttgtttaggt cgcgcgcact gtccaggtcg tggccgaagg gttgctcggt gacaacccgg 17940 ctccagctgt aggtttgtgg acgagccaat tcagacttat gaagctggtc acagaccacc 18000 gggaaagatt tgggtgggat cgccagttag aattcctgat tgccgctggt ggtgggcttg 18060 gtgtccagct tgtccatggc atcggccagt cgggcgaacg catcatcatt gtcataaaga 18120 gcccgatacg aaccggagtc cttcctccag ctggcttcag ttcgcctgca gaaatgcgtc 18180 cggcagtgct ctttgacggc gttgtggacg acgtcactgc aatcctgggt gctaaaatcg 18240 cgtcatgcga agatctacca tggaaaacat gggtggtgac aggttccggc tggccatatc 18300 gtaagttgct gacatcactt taacttgtgg gacaggtcgc cggtgacccc taaaatcacc 18360 atcgtgcacc gggtggctat tctgggtagc tacctattag ccttgtaccg tagcgggttc 18420 tgccattgag ttgcagtgga ggtacgtgtg gctactgggt tcatttggcg acggagtcca 18480 gctgttcctg agtttccttg agtagctcgt tccaggattt cacaaacttc tgcacgccct 18540 catgttctag taccgcgaac acatcaatca gatcgactcc gaccgccacc agtgagtcga 18600 acactttttg ggaggacaaa gtagtaccgc tgatcgtgtc accacggatc acaccgtgat 18660 cggctacggc atcaatcgtc gtctccggca tagtgttcac cgtgtttgga gctaccagct 18720 cggtgacgta cagggtgtcg gcgtaatcgg ggttcttgac accggttgac gcccacagcg 18780 ggcgctgtac ttgggctccg cgggccatga gtgtctggta gcgctggcca ccttcgaagg 18840 ccttctggta ggccgcgtag gccaatcggg cgttggcgac accggcctgg ccgcgtagcg 18900 cgagtgcttg ctcggaacca agtttttcta gtcgcttgtc gatttcggtg tccacgcggg 18960 agacaaaaaa cgatgctact gagactatct tggataggtc gcgtccagct tcggcggcct 19020 tttctatccc ggccaggtag gcgtcaatta cctcgcgatg ccgctgtaca gagaaaatca 19080 gcgtgacgtt gaccgaaatg ccttccgcta aaacggcggt gatcgccggt aggccagcct 19140 tagtcgccgg gatcttgatg aacaagttcg ggtggtcaac tattctccat agttcgacgg 19200 cttgcgcgat agtcttgtcg gtgtcatgtg ctaaacgggg atcgacttca atcgagactc 19260 ggccatcttt tccgtgggaa gcttcccatt cacacgccaa cacgtcgcat gcgtggcgaa 19320 catcgtcagt ggtgacggtg cggacggtga catctacgtt ggcgccgcgc ttggccagct 19380 cggcaatttg ggcatcgtag gcgtggccgt ttgcgaatgc tttctggaag atggacgggt 19440 tggtggtcac gccaacgaca ctcttggtgt caatcagctt ctgtaggttg cctgactgca 19500 accggtctcg cgacaagtcg tccaaccaaa cggacactcc ggcagcgctc aatgcggcga 19560 ggttggggtt ctgaattttt gaggtcatac agatcgcctt tttttcagtt atccaatacc 19620 tgttccgctg cggcaaccac ggcctccggc gtgaagccgt actcacggaa caaagtctgg 19680 taatctgcgg attcgccgta gtgctcgatg gacacaatct tgccggtgtc tccgaccagc 19740 ttatgccagc attgcgcgac gccggcctcg acggccaccc gtgccgacac tgacgggggc 19800 aacacactgt cgcgatactc gtacggctgt gactcgaacc attccacaca cggcatcgac 19860 accacccgca caatgatgtc tttatccgcc aacaacttct gagctgcgac agcgagttgg 19920 acctcggatc cggtggcgat caaaatgacg tcaggctcct tagcttcaga gctgccacca 19980 tcgcctagca catagccgcc tcgggcgacg ccttcggtgt tggtgccttc caacactggc 20040 acactctgcc gggtcaggat tagcccgacc ggaccgctgt tggcgccgcg agccaggatt 20100 gtgcgccagg catatgccgt ttcgttggca tcggcgggac gcaccaccga caatcgaggg 20160 atagcacgca acgctgcgag gtgttcgatg ggctgatggg ttgggccgtc ctcgccgagt 20220 ccgaccgaat cgtgcgtcca cacgtagatc gtgtcaatat ccatcaacga cgccagtcgc 20280 accgacgggc gcatgtagtc ggagaattgt agaaatgtac caccatatgc gcgggtgggg 20340 ccgtgcagca cgatgccgga cagaatggcg cccatcgcgt gttcgcgaac accgaaatgc 20400 aaggtgcgac cataccaatg tgcggtgtac tcgtcggtcg aaatcgacgg cggcccaaag 20460 gaatcaacgt cttttatggt ggtgttgttg ctgcccgcta gatcggccga cccgccccac 20520 aactccggga gtttcggtcc tatcgcggat agtaccgcac cagatgcggc gcgggtggcc 20580 aattccttgg acctcggctc ccagttcggc aggtcagcat cccagccgtc gggaagctgc 20640 tgggcgagca accgatccaa cagtgccttg cgttcgggct cgcgctgtgc ccacgcttcg 20700 aattctagtt gccagcgttc gtgggcttct ttgccgcggg ctatcaagcc gcgggtgtgg 20760 gtgattacgt cctcgcggac tgcaaaggtc ttgtcgggat cgaacccaag gattcgctta 20820 gtggccgcta cctcgtcttc gccaagggcc gcaccgtgcg ctttgccggt gtttatcaag 20880 gttggcgcgg gataaccgat gatggtgcgc agtgagatga acgacggccg gtcggtggcg 20940 gctttcgcgt tggcgatggc ttcctcaatg ccgacgacgt tctcgccacc ttccacctct 21000 tgtacgtgcc agccgtaggc gcggtagcgt gcggcggtgt cctcgcacag cgtgattttg 21060 gtgtcgcctt cgatcgagat ctggttgtgg tcgtagaaca cgatgaggtt gccgagttgc 21120 tggactgcgg ccagggacga cgcttccgat gtcacccctt cttcgatgtc cccgtcggag 21180 gcgatcacat aaatgtaatg gtcgaaaggg ctggctcccg gttcagcgtc ggggtcgaac 21240 aggccacgtt cgtaacgtga tgccatcgcc atcccgactg ctgatgctag accctggccg 21300 agtgggccgg tggtgatctc aacaccctta gtgtgccgga actctggatg cccaggagtt 21360 gtggatcccc aggtgcgcag cgattcgatg tcagatagtt cgagaccgaa gccgccgaga 21420 tagagttgta tatataaggt caggctgcta tgcccggccg acagcacgaa tcggtcacga 21480 cccagccatg cggtgtcatt ggggtcgtgg cgtagagtgc gctggaacaa agtgtaggcc 21540 agcggggcca agctcatcgc cgtccccggg tgcccgttgc cagctttttg gaccgcgtcg 21600 gtagccaaca ccctgatggt gtcgactgca gccgaatcga tctcggtcca gtcatcggga 21660 tggcgcggtt gggtcagcgt ggagatctgg tcgagtgtgg tcacgaatca gtccttgggt 21720 cagctgttca ggtcatcaaa ctgattaatc tcaccctagt gtggaagtgc gggcctgttg 21780 cagggcccgg tttccaggta cctacggttc gctgtggcgc aactagcctg cgtctgttcg 21840 cgccctcttt gcaatctggg aaaaatctgc gttgaaagac ctgtcgggct gttggctacg 21900 ggcatgcggt ctaccatcgt gcgtagtaga agctgcgcgc tgctgcgatc tcgaggagtt 21960 aagtacgtga gcgttcgcgc gcgcttagcg cggagccgag tgttggcata tctggcgttg 22020 accaagccgc gcgtcatcga gctgcttttg gtcaccgcca taccagcgat gctgctcgcc 22080 gaccgcggta gcgctaatcc gctgttgatc ctcaatacgt tactcggcgg gatatcggct 22140 gccgcaggtg ccaacacgtt caactgtgtt gccgacgccg atatcgacaa actgatgaag 22200 cggacttccc ggcggccgct ggcgcgggcc gcggtgcccc cccgaaatgc cttggtgctc 22260 gggctggcgt tgactgcggg ttcattcttc tggctgtggt ggactaccaa tctgctgtcg 22320 gggctgctgg cgctcgccac cgtcgcgttc tacgtattcg tttacacgct gttgctcaag 22380 cgccggacgt cgcaaaacgt cgtgtggggc ggtgcggctg ggtgtatgcc ggtgatgatt 22440 ggttggtcgg cgatcaccga cactatcggc tggccagcat tggcaatgtt tgccatcatc 22500 ttcttctgga ctccgccgca cacctgggca ttggcgatgc gctacaagga cgactacaaa 22560 gtggccagcg tcccgatgct tccggccgtg gcgaccgagc gtcacgtcac caaacagata 22620 ttgatctata cctggctcac cgcattgtct acgctggtgt tggcactggc gacggggtgg 22680 ctgtacatgg cggtggccgt cgtcgccggg gcatggtttt taacgatggc ccatcagtta 22740 tacgtcgggg tctgtgccgg tgagccggtc aagccgctac ggctgttcct gcaatcaaac 22800 aactatctgg cggtggtgtt ttgcgcgtta gcggtcgact cggtgctcgc cttgccgaca 22860 ctattttgat tttgatcacc tctttggtgg ctcgagctta aagcagcaac ttgaccgagc 22920 cgacggtctt gcggccttgc agatcttcgt gggtgcgggt ggtttcggac agcgggtagt 22980 gtgtacaccg acctcgatgg tgacggctcc gctgccgatt gcttcgaaca gttagactgg 23040 gtccgtcagc tgaactcctc gccggttcgg attaaattgg ccagcgtcgg ccgggtgagg 23100 tagagtgagc cggcggcgtt gaggtgctgc ggatcgacag gcacagcggt tccgcttgtg 23160 tcacgaaaaa gtgccagtgt cccgcggaca gccatgttgg cgtcaaagtt ggttacctct 23220 aagctggcat aaaacgctgc cacattgggg caccttcggt tgagtgcccg aatttgctgg 23280 ccgaattggg cagcttcggg acagtacagc accttgtcgg cgtcagcccc gttggacaat 23340 tgtgcttttc cgcattcgag acggtgatca gctcccccca tccatatcac cagctccgca 23400 ccgggtgcac cgacttcagt aaagagtggg cggccagggc atctagtagt actacgttgc 23460 cgcctcaaaa tactcctcat gggcactttg tcggtcaaaa atgctgttaa agagaaagat 23520 tcaacctagc ttccgttagc cgtggcgcta accacccggt ctcctacgtc gacaccgttg 23580 gtgtcgacgt cctcgccagc aacaacggca gtaccgcata ctttcgagcc gaggatgaac 23640 ggcactgggc ggatacgttt tcgttgaagg aaattaggtg ttgatgaagt tgtttatgtc 23700 aataccttcg gccgtgatca gtagcttacc ttgcgtgggc tgggcggcgg cttgtcgaca 23760 tagcgcagga cttcagggtc gccagtttcg acgatttcgg ttgcatgcat gtggcttatc 23820 catgcccggg catgaagatc gcacgaccag acctcttcca tccccacatc gtgttggcgg 23880 gttctcgcca gcaggttgct ggtgccggcg atgatgccgg gctcgttctg gctgctgcga 23940 cgctacggcc tacacgccca gtggttgctc tgggacgatc ccgagctcgg cagcgagcgc 24000 ggacctggta gtcttgcggg ctatctacga ctacgctgaa cagctcgacg agtacctggc 24060 ctggaccatt ggtgtgccca atctgctgaa tccatccatc gccgccacct ggaatgtcga 24120 ccggcgttac ttggcggatc cggggaatcg aggggggtcg acggtgtcgg ctaaggtgtt 24180 agctccaggc gatcaggtcc ggtggccggg tcctggcgct gtcttcgtca gcccgaccgt 24240 cggcaccggc acatggtgtt gcaacgatcg gtccgcggtg gctacctacg tggctgaact 24300 gagccagggt ggaccgaccc cgttctcgtg cagacggcgg gttgggcgaa gaaacggtac 24360 cgatcttcat cagtggtgag gctgtagcgc acgtctacca agcaggacat gctggttcag 24420 gccgagcccg atttcgaaat ctgggatatc ggcgttgcta aaggctgcgg caaccgaggc 24480 gggcatcgac gtcggcgagt ggctgtatgt gcgcgcccac ttggtcgatg gtcgccggaa 24540 gtctcggtta ctggaattgc agctggtgga accgtcgcta gactggcgat gattggacgc 24600 cggtatccgc taccatgccc aatgcgaatt tgcgctgggt gtggagttag cgtgagagcg 24660 actcgggtta ggaccgggtt cgcattgagg cccatagcgc tgcggtggct gcggtacacg 24720 ccgcagcacc agctacatgg actgcgacca gggcggcagg caccccggtg aagtattgtg 24780 tggtgccaac agcggcttgc gcgcaaacca gagcgaacaa cacggcgagc cgcaccagga 24840 tggcccgggt ggcaccgacc gccaatagcc cgaagcccag cccaaccagc agtgctaagt 24900 aggcgaccag caacgacgaa tgcaggtgcg ccagggtggt gatttcgact cttagccggg 24960 gaaccgtgcg gctgggactg cggtctcccg cgtgcgggcc agcagccgtc accagcgtgc 25020 cggttaccag caccaccgcc agatttactg cggttagggc tgtcagtgcg cacagcggcc 25080 ggattacccg ctcataagca attccaccat cgggttcacc gaccttaacg tagagcaaca 25140 ccgccagcca caccataatc atcgatgtca gtagatggat ggcgactgtc caccacagca 25200 gcccggtaag cacggtgatg ccgccgatga ccgcctgcag caccgtcgag atcggcatta 25260 gccaagcgta gacccgaact tcggtgcgtc gtcgcgcccg ggtaacggtt aaaacggcca 25320 gcaacgcggc gatgaccact gcgatgctga ctacccggtt accaaattcg actgcctggt 25380 ggattcgtgg tacctcggtg acggcgaccg gggtgaagct gcccggaaaa cactgtggcc 25440 aggtgggaca gcctagcccg gacgccgtga cgcgaacgat cgcgccggtg acggtaatac 25500 cgccctgggt taggaggacg gtcgcggcaa tgatccgctg gacacgcaga ccagggtcgg 25560 gtattaggtc gactagtcgc aacagaattc gtccgacaag caccgcacga tcgtaagaca 25620 atgaaaacta cacccggtag taggggattg gtacagtcgg gtgctgtaac tgcagcctgg 25680 caggaccatt cccggggctg gttcaatacg gtttcggtgc aacaggtgga tccggcgcga 25740 gtgggcgttc gatggccact tccagcaagc gcagcgcggt atcgcgacgc cgtgggtacc 25800 aagtagcccg gttaggtggt tgctcgctcg gtagtgggct ggctgttagg ctagtaagtg 25860 gtgattggca gccttgacat tctatttttg gccgctaggc ctgtccagct cacgcggacg 25920 gcgggtcaac aaaatgatgt gtttgtggtg gtggctgctc tgatcgagga gtgcgagcac 25980 tggggtttgt ggggaccggc tgccaaggag acggtcgtgc agcctgccag attgtgcacg 26040 ttgagcggtg atggattcgg cgctggtccg cgggtggcga tgctgccggg cacctggtag 26100 taggtttgct tggcgtagtg agttaacggg ctaccccacc acttaagtgg ccaatgacgt 26160 ggtcagaccc agtcactggg tggcgggtga tgttcggttc cgtagctgcc gtgtcgtggt 26220 cgtcgtatcg ggatcaggtg aaccggaacc agtgaagtgc cgcgagcgcc gcgagcgtgc 26280 cccatgccgt caggatgatg accccgaacc agtccaccga cagagtcatc gcctgcgaca 26340 gcgcctctgt cagtgcaccc gagggggtta ggcgggctgc ccacttaacc accgccgaga 26400 tcatgttcat cttgacagtt agcgcgccaa gtccggcgaa cacgaaccac atcaggttgg 26460 ctactgcgag gacgatctcg gcccgcaagg tgccgccgag cagcaggcca agtgccgcta 26520 agcccgcggt gcccagcgcg atgatcgccg cacccagcgc caaacagatc agcgccggcc 26580 gccaacccag cataacgcca atggcgccca agatgattgc ctgcaagaac acaacggtta 26640 cgactgccag ggacttgccg gcaatgatac cccaaaccgg tagcggggtg gctccgaatc 26700 ttttgagtgc gccgtagcga cgatcaaaag caaccgcgat ggcttgcccg gtgaatgcgc 26760 tagagaccac tgccagcgcc atgatgaccg gtacaaacgt ggtggcgcga tggtggccga 26820 aggagccaag tggcagcagt gtgaggccga tcagcagggt gatcgggatg aacatggtca 26880 gcagcaattg ctcgccgttg cgtagcagca gcttaagctc cagcataaac tgtgcggcca 26940 ccatccgggt cacggcgttg ggtcggggat ttggagtgaa agtgccagcg ggaaatagtg 27000 ggctgttcct tagtgtgttg ttttgcgtca ctaccgcaac ttcctgccgg tgagatccag 27060 gaacacgtct tcgaggctgt gttgctcgac ccgcatattg gtggtcagca cattgatttg 27120 tgcgcaccaa gccgtgacgg tcgccagcac ctgggggtcg atggggcctg cgaccaagta 27180 ctcgcccgga gtgagctccg tggtcttgta gtcctccggt agtgcgaacg ccaagagtga 27240 caagtccagc cgcggcggcg cgctaaaccg cagctggtct ttagcgccgg tgtgcatcaa 27300 ttcggtcggc gttccggcgg caatcatgcg tccgtggtca atgatgacca gtcggtcggc 27360 gagttcctca gcctctttca gttggtgagt ggtcagcacc actgtcacgc cgtctcggcg 27420 cagcgtgtcg atcaactccc acaccagcag cctggcgtgc gtatccatgc ccgcggtggg 27480 ctcgtccagg aataccagtt cgggacggcc gaccaacgtg caggccaggg caagccgttg 27540 ctgctggccg ccggacagtc gccggtaggt ggtgcgggca acgtcggtga ggcctaaggt 27600 ttccagcagc cactctgggt ccagcgggtc agcggcatat gaggccacca ggttgagcat 27660 ttctcctgcg cgtgctgctg ggtaaccgcc cccaccctgc aacattactc cgatacgggc 27720 gcgcagacgt gcgttgtcgg tgatagggtc caggccgagt acctcaatcg tgccggcatc 27780 gggacgtacg aagccctcgc acatctcaac cgtcgtcgtc ttgccggcgc cgttgggccc 27840 cagcagggcc agtacctcgg cggaatggat gtccagatcg aggttcgata cagccaatat 27900 ggacccgtag tgcttgcata ccccgcgtag ccggatgacg acttcgggag tttcggggac 27960 tgtgcaggcc gagctcatgt taagttagcg taggcggtcg gcagccgggt cgcaggagac 28020 gcggagttct gcgaggtctc cgggtccggt gcaacaaccc tcaccagttg ttgatccagt 28080 tcgctcctct tggctgggac catctggagt ggtcgccatg gcaagcgggt gtaggttagt 28140 gcaatgagca ccaacacgat gatggtgctg gccacggtgg catccacaat ttggaacagc 28200 gcgaaacgat caccgttggc cgtagggccg aagacgccca cgacgatggt gacggtgatt 28260 gcagccactc ggaagccggt gcgggtcgcc caggcggcta gcggaatgat ggcccacagc 28320 agataccagg gttgcacgac gggaaacagc aacaccgtga cgcccagcgc gacgccgagg 28380 ccgccgatcg ggtgtagccg accgcggaac acagctagca acaaccaaca ggccatgacc 28440 atgatgatca gtacgccgat gccgcgggtc aacgacagca ctgcagtggt gtgatccccc 28500 agacccagca gaatacccac gtgcccggta ccgagagcta gtagcgtcgg cggtgacatc 28560 cagctgcgta ctacgtttgc ggtgcccaac gtgtagatcc agccaaaccc gagtccactg 28620 gcccagccaa cgatgcccat cactgccaga gacaatcctg ccatccacaa gctgaccatt 28680 agcagtgctt gcggggtact gccaagtcgg caggctagcg ccatcgcgac gaatcccagt 28740 gccagcagcg acggcagctt cacttgtgaa gacagtacga tcaggatcga accggccagc 28800 aacatgccca gcggctccca attcgagccg aaccggattg cctggcttgt aagcgtgccg 28860 ctgtgttgcc tgccggtacc tccaccgcgc caggaggtgg gtatcactcg tgttgtggac 28920 gagaagtcaa tgccacgcag agcgaattcg gcccctgtga gcataagccc tagcatcggt 28980 gcctcgttgt ggatgccggc gactagatgc atgattagca gtgggttggc tgcacctagc 29040 cataacgcgc taacctcgac cacgccgcag cgtcgggcca gttgcggggt tgcccacacg 29100 accaggccga cgccgattaa catcatcaac cggtggcaga gtaccgcggc gacgatgttg 29160 tctccggtca gtgctgagat tccgcgcccg atccacaaaa acagtgggcc gtagggtgcg 29220 ggtgtttccc gccataggct gggtaccgaa agcgtgaaca cctggcctag tcccagtgcg 29280 gacgccggac ctacccggta agggtcgagt ccctgtaggg agatctggct ttgcgcgagg 29340 taggagtaga catccttgct gtacatcggt ggtgcaatca atagcggcag cgtccacagc 29400 aacagggtgc ggtccagctc gccgcgcgac atctgtctcc tgcccagcgc gaaccggccg 29460 agcatcaacc aggccagcgt catcatgacc gccccggttg tagtcatcgt caacgagacc 29520 gtctggattc ttgacggcag attgagcagc cgaaccccga acgtggggtc ctggatgacg 29580 ggcctggccc ctgctccgag cgcgccaatc gccatcagga tggtgccggt agccccaaac 29640 aagcgggtgc gctgtagtgc gccacggtcg gcatcgttca gtggtgagcc cactgcctgc 29700 tcatcaccat gcaagctggc gatggatgag ctcagtgtgt ggtggcgggc tgccatcaga 29760 ggagcgtagc cctaacgacg aggcgagtcc cggaacgcga gccgttgcgg gacggggtta 29820 tcaggcttag cagcatgcca gccggcgctg gggcaaggtt caggatgtga tgtgctcaac 29880 gttcaccgag ggtacccttc cctagaccga tcgccagaat tgcgtcacac tggtgttgtg 29940 aaaatccggt cggagctgga tgctgctacg acagtcgcag tgtcggatgg tcacactcgc 30000 cgcgcggtgg tgcgcttgtt gctggagtcc gggtcgatca ccgccggtga aatcagcgac 30060 cgtctgggtc tgtcggccgc aggcgtgcga cgtcatctcg atgtgctcat cgagatgggc 30120 gacgctgagt ccgcgactgc ggcgccctgg cagcaggttg gccgcggccg ccccgccaag 30180 cactatcggc tgaccgcggt gggccgggcc aagctcggtc atgcttacga caccttggcg 30240 tcggctgcta tgcgacaact gcgggaaatc ggcggggagg acgctgttcg cacgttcgct 30300 cgacaacgta tcgacgcgat cttggccgat gttgagccag ccggtggcgg agccgacgtt 30360 gaggcagccg ccaaccgggt tgccagtgcg ctgagtgacg ccggttacgt cgcaaccacc 30420 gcgcgggtgg gcggaccgat ccacggagtg gagatctgcc agcatcattg tccagtgtcc 30480 catgtcgccg aggaattccc cgagttgtgt gaaaccgagc agcaggccat tgccgaggtg 30540 ctcggaaccc acgtgcagcg gttggcgatg atcgtcaacg gagattgtgc ctgtactacc 30600 cacgtgccac tcatgtcggt accaagcaag acctagcagt gcggcactca ggccgcgcca 30660 cacaacgagc accaaaggag cgctcagatg acacgcacgt cagagactac gaagtcgccg 30720 gctcccgagt tgttgaccca gcagcaggca atcgactcgc tgggtaaata cggttacggg 30780 tgggcggatt ccgacgtcgc gggcgccagc gcgcggcgcg ggctctccga agatgttgtt 30840 cgggacatat cagcgaaaaa ggatgagccg gaatggatgc tgcaggccag gctaaaggcg 30900 ttgcgtgtct ttgagcgtaa gcccatgccg cgctggggtt ccaatctcga tgggatcgat 30960 ttcgacaaca tcaagtactt cgtgcgctct accgagaagc aggccgccag ctgggatgag 31020 ctgccagaag acatccgcaa cacctacgac cggctaggaa tcccggacgc ggaaaagcag 31080 cgtctcgttg ccggcgtagc ggcgcaatac gagtcagagg tagtttacca ccaaatcaga 31140 gcggacttga aggatcaagg tgtcgtcttc ctcgacacag aaacgggttt gcgggaatac 31200 cctgacatct tcaagcagta cttaggcact gtgatcccgg cgggcgataa taagttttcc 31260 gcattgaata cggcagtgtg gagtggcggg tgtctaaccg ccgatgctcg tattaatgtc 31320 aagggcaagg gcttggtgag tattgccgat gtccagcccg gtgatgaagt gtttggtgta 31380 aatattggat gcgaactcga gcgtggcaaa gtgttggcta aggtggcaag cggcaccaag 31440 cccgtatacg agatgcacgt tgcaggtcgg gccctcgaag caaccggaaa ccatcaattc 31500 ttagtggcaa ggagagtcga ggagggtaag cgcacacggt ggacggccgt ttgggcacca 31560 ctcgaggaga ttgagtcggg tgagccgatc gcggtcgctc gcgtgttgcc cgacgatagc 31620 ggaaccattt tcttctccga gtcggaactg gacatcaaga accgaacccg gcagtgtctc 31680 tattttccat gccagaacag cgttgatctg ctttggctct tgggattgtg gctaggtgat 31740 ggtcataccg ctgcaccgca taagcacatg cggcaagtcg cgttctcggt ccctgcaggt 31800 gatccagtgc atcacactgc catccgggtg gtgagtgaac agttcggtgc caacgtcaca 31860 gtggtgaatt gtggattcat cgtgagttcc aaggctttcg agacatggct tgcagaactt 31920 ggattttccg gagacgagaa aaccaagcgg ctgcctgcct ggatttatag cttgccgcat 31980 gagcaccagc tcgcgcttat tggcggactg gtcgatgctg atggttggac cgagagcagt 32040 ggtgccacca tgtcgatcgc gtttgccagc cgggagctgc tcgaagacgt caggcaactt 32100 gctatcggtt gcgggctata ccccgacggg gcgctcgttg agcgaacacg gagtgcaacc 32160 tgcagggacg gtcgcatcgt cacgagcacg agttggcggt tgcggattca gggcagtctc 32220 gaccgagtag gtactcgtac acctggcaag cgagggaaac cggtgagcaa caaggggaga 32280 agacagcggt atgttgctgc cgctgggctt aatttctcgt cattgtccac cgataccgtc 32340 ggcttcgcac gtttgaagag taagacgctg gtgggcgaga agcccaccta cgacatccag 32400 gttgtgggtt tggagaattt cgttgcaaac gggatcgtgg cgcacaacag cttcatttat 32460 gtcccgccgg gtgtgcacgt tgatatcccg ctgcaagcct atttccggat caataccgag 32520 aacatgggtc agttcgagcg gacgttgatc atcgccgata cgggctcgta cgtgcattac 32580 gttgagggtt gtaccgcacc aatctacaag tcggactcgc tgcactccgc ggtggtcgaa 32640 atcatcgtga aaccgcatgc tcgcgttcgc tatacgacca tccagaactg gtcgaacaac 32700 gtctacaact tagtcaccaa gcgcgcccgt gttgaaacgg gtgccaccat ggagtggatc 32760 gacggcaaca tcgggtctaa ggtcaccatg aagtacccgg cggtttggat gaccggtgaa 32820 cacgccaaag gtgaggtgtt gtcagtggcg ttcgctggtg aaggccagca ccaggatacc 32880 ggggccaaga tgctgcacct ggcgtcgaac acgtcgagta atattgtgtc caagtcggtg 32940 gcccgaggtg ggggccgcac ctcctaccgt ggtctggtgc aggttaataa aggtgcacac 33000 gggtcgcgct ccagcgtaaa atgcgatgcg ctgctggttg atacgatcag ccgcagtgac 33060 acgtatccgt acgtcgatat ccgcgaagac gacgtcacga tgggccatga ggccaccgtc 33120 tcgaaggtca gcgagaacca gttgttctac ttgatgagcc gtgggttggc cgaggatgag 33180 gcaatggcga tggtggtgcg cggcttcgtc gagccgatag ccaaggagct accgatggag 33240 tacgcgctgg aactcaaccg attgatcgaa ttgcagatgg agggtgcggt cggatgaccg 33300 ctgttgaagg atcttcactt acagcattga ataaggggag gttgttcgcg tcgtttgatg 33360 tcgacgcttt cgaagtgccc ggtggccgtg acgagatttg gcggtttacg ccgctgcgga 33420 ggttgcgcgg cctacacgac ggctcggccg tggccaatgg caaggtgcat attagagtca 33480 gccagcagtc tggtgtgcag accgagatcg tgggccgtgg cgacggacgg ctggggcagg 33540 gcggcatccc cactgatcgt gttgcagccc aggcattttc gtcgttccag tccgcgacgg 33600 tggtcactgt cgggcgggat atgcagatcg ctaccccgat caacatcgcc gtaaccgggc 33660 ccgacaaagg cgcagtggtg tacggtcatc tacagatcag ggtctgcaaa tttggcgaag 33720 ctgtcgtggt cattgaccac cgggggagtg gaacttacgc cgacaacgtc gagttcattg 33780 tcgaggccgc cgcacggctc accgtggtgt ggattgctga ctgggccgac gatatggttc 33840 atctcagcgc acatcatgcc ctgctgggca aagatgcggt gctgcggcat atcactgtca 33900 cactgggtgg cgaggtcgtc cgggtgtcgg ccaatgtacg gttctccggg cccggtggcg 33960 atgccgagct gctgggtttg tacttcgccg acgacgggca gcacctcgag tcccggctgc 34020 tggtcgatca cgctcatccc gactgcaaat cgaatgtgct gtacaaaggt gcactgcaag 34080 gagatccggt ctcgtcacgg ccagatgctc ataccgtttg ggtcggggac gtgttgattc 34140 accccgaggc gactggcacc gacaccttcg aggtgaaccg taatctggtg ctcaccaacg 34200 gtgtgcgtgc cgactcggtg cccaacttgg agattgagac tgatgaaatt gttggtgccg 34260 gacatgccag cgctaccgga cgttttgacg atgaacagct gttttatctg cgttcccgtg 34320 gcattggtga agagcaagcc cgccggctgc tggtccgcgg ctttttcggc gaaattatct 34380 ccaagatcgc ggtgccccag gtgcgggagc ggctgatcgc agctatcgaa cacgaactga 34440 ccatcacgga atcgagatca acagcctcat gacgactttg atagtcaaag acttgtacgt 34500 aagcgttgag catcccaacg ccgctgaatc cgagtgccag atccccatcc tcaatggcgt 34560 cgacctgacc gtgaaatctg gggaaacgca tgcgttgatg ggccccaacg gatccggcaa 34620 gtccacgttg tcttatgcta tcatgggcca tcccaagtac cgggttatct cgggtgccat 34680 cacactagac ggcgcggacg tgctaacgat gagcgttgac gagcgcgcgc gagccgggtt 34740 gtttctagcc atgcagtatc ccgttgaggt tcctggagta tcggtgtcga actttctgcg 34800 ctcggccgcg accgtcattc gcggcgaacc gcctaaacta cggcactggg tcaaagaggt 34860 gaaagccgcg atgggtgcgc tggagatcga tccggttttc gccgaacgca gtgtcaacga 34920 gggcttctcc ggtggcgaaa agaagcgcca tgagatcctg caactggaac tgctcaagcc 34980 taaaatcgcc atcttagacg agaccgattc cgggttggat gtcgacgcgt tgcgtgtggt 35040 tagcgatggg gtgaaccgct acgctgattc ggagcacggc ggcattttgt tgatcaccca 35100 ctatacgcgc atcctgcgct acattcgtcc ggaattcgta cacgtgtttg tcggcggccg 35160 gatcgtcgaa tctggtggct cggagctggc cgacgaactt gagcagaacg gctacgtacg 35220 tttctcccaa ccggcggcaa ccggagtcta agtatgacta tctcgctgac cccattggat 35280 ctctcggcga ttcgtgcgga ttttccgatc ctaaagcgcg tcatgcgggg tggaaaccag 35340 ttagcatatc tggattctgg ggcgacgtcg cagcgcccgg ttcaggtact cgacgctgag 35400 cgggagtttc ttgttacgtc caacggtgcg gtgcatcgtg gtgcgcacca attgatggaa 35460 gaggccactg acgcctacga gcgggggcgc gtcgacatag cggcatttat cggtgctgcc 35520 gccgacgaat tggtcttcac taagaacgct accgagtcgc tcaatttagt gtcatatgtc 35580 ttcggcgaca atcggttcga gggtacgtcc ggtgacggtg gtgatgttat tgtcactacc 35640 gagctcgagc accacgctaa cctgattcca tggcaggagc tagcccggcg tattggtgcg 35700 acgttacgct ggtacggagt caccgacgac gggcaaatcg acttggactc gctacagctc 35760 gacgagcgcg tcaaggtcgt cgctttcagc catcactcca atgtgactgg tgcggtggct 35820 cctgtgcgtg agctggtagc gagagccaag gaggtgggtg cactaacagt tctggacgcc 35880 tgtcagtcgg tgccgcacca gccggtcgat ttgcatggtt tgggtgttga cttcgcagcg 35940 ttctccggac ataaaatgtt gggccccaac gggataggtg ttctatatgc gcggcgtgag 36000 ctgttatcgg tgatgcctcc atttcttacc ggcggttcga tgatcgagac ggttactatg 36060 gaaagtacga cgtatgctcc ggcgccgcag cggtttgaag ccggtacccc gatgacttcc 36120 caggtggttg gattagccgc agccgcacgc tatctcgacg ccatcgggat gaaagccgtc 36180 gaagcccacg aacgcgagtt ggtagcagcg gcggttgagg gtctgtccag aatcgatggt 36240 gtacgcataa tcgggccgaa gtcgatggag aaccgcggct cgccagtgtc gttcgtcgtc 36300 gacggcgtgc acgcgcacga tatcggtcag gtgttagacg acgacggcgt cgccgtgcgg 36360 gtcgggcacc actgtgcgtt gccgctgcat cgccggtttg ctttagcggc cactgcgcgg 36420 gcgtcgtttg ccgtgtacaa caccgtcgat gaagtcgacc gcttggtggc aggtgtgtta 36480 cgagctttgg atttctttgg gagagaatga tattgcgtct agaacagatc tatcaggaag 36540 tgatcctcga tcactataaa cacccccagc atcgcgggct acgtgagccg ttctgtgctc 36600 aagtgtacca cgtcaacccg atctgcggtg acgagatcac cttgcgcgtg gcattatccg 36660 acaacggtgc tagtgtcgca gatatttcgt atgaaggaca aggttgttcg atcagccagg 36720 cgtcgatctc ggtgcttgct cagcaggtga tcggtcagag tgttcctgac gcactgaaca 36780 tcatctccgc gttcaccgag atggtgtcct cgcgcggaac gattgagggt gacgaggacg 36840 tcctgggtga tggggtagcg ttcgccggag tagccaagta cccggcccgt gtcaaatgcg 36900 cgttacttgg ctggatggct tgcaaagatg ctttgataca tgctaattcg gcagataaag 36960 tcctcgagga ggtcatggat gagcaaaatc accgcgtcgg gtgacgagtt gcttgccgac 37020 gttgaagagg ctatgcgtga cgtcgtcgac ccagaattgg ggatcaacgt cgtcgatctc 37080 ggactggtct atggcttggg tcttgaagag ggcaaagaag gaatgatcgc cttggttgac 37140 atgacgttga cgtcggcagc ctgtccactg aacgacgtta tcgaagagca gtcacgcagc 37200 gcgttggtcg gcagtggtct ggtcagcgac ctgcggatca attgggtttg gaacccgccg 37260 tggggcccgg acaaaatcag cgatgacggg cgtgaacaac tgcgcgctct cggctttacc 37320 gtctgaaaac taaaggtatc aaccttcttc cttccctgcg ggttcccggt gacttcagga 37380 tcggcgagtg ccactacaag tggggtgtat ataagttgtg cgtgatcggt cagaacgttt 37440 tcgtcggaga cgagcatgat ctcatcatcg atggattcga tgatgccgcg cagtgcggtc 37500 aatctcggca acatgtcctt ggcgaggaac gttgcggccg tgattttgca ttgatagaac 37560 gctgaatcag tttttgtgtc tttgcgtgtc gcgatgttgg ctagtgtggt gcgtgcaatt 37620 atagacttgt accagtaatc gtcattcgat caacagatcg tcggcggccg gcaggtaacg 37680 cactgattcg agccccacct cgtgaatata ggtgaggtgt tgcgcggtgg acatgaggta 37740 ttctggtcag cgcacccgtc atcgccgtga tgtcgtcgag cgcagtcaca agcagcttgg 37800 catcggtttt cattgattta ttgcagtttt cgatggtgtg actggtccga gctgttatgt 37860 gttgtaatgc ttgaccgtgg tcacggtggt gtaccccgtt gggatctgcg cacaaaactt 37920 gttgtactat catagacacc ctggtgtgct gtggcataaa gattaaggcc cgtatgtcct 37980 cgacgtaggc cttcttgggc ataagactgc ggcacacatc agggtggtgc atgatcgtga 38040 cctgtggtgt ggtcttatta ggtcatttgg gtcaaatctg cgccttggac ttgtttctgc 38100 gcgtagacaa gcgggttcag gtagccggtg gacagcatgc cggtcgactt aacgccgatc 38160 gtcatgcgag tgtacttcaa tgattggcga ctatctgtgc gatcccgttg tgcacgccac 38220 cggtcagata gccaacggcg ggtacgtcag tggcgccgaa agcagctcgt acgtggggga 38280 ggacttaagc catatcgcac gataacaaaa acgccgttgt agggaccgaa ttcgaaggct 38340 tcgggatcta aaaggttttt ggggatatat gaacaagctt acccctttag tacccggact 38400 aacgtcctcg agccaggcag gcactaaatg gaagatgttc ggcggtactg gcgccgtctc 38460 ctccagagac gaatcgcttg acctcctcga tgtgccaggt gtcgtcgggt tattcgacgg 38520 ccttggccta ggccgggctc gtcaggccat tagcgctaga cacccccgtc gctgcttgtt 38580 tgttgccttc gatgtagagc gccttggcca tcaccgggac caaattgaag agtacgctga 38640 gggattagcg cagaagatca ttgcgttggc aacccaggtc aacggcggct gtgtggccct 38700 gccaccgatc tcctcggtca gacccaggag gcctactcag cttctttgat ggcttggacc 38760 gacttgacca attcggcgag catgctgatg gtgtggatcg cggggtcgaa caccggtggg 38820 ttgcgttctg cgtagccaaa agactcagca accagttctt ccgccaagcg agcggcttcg 38880 gtcaatattg ttcgcactgt gtcaacgtcg atatcgtcgt aacgtctagt gccgaggacg 38940 gctgctagat aaaggacctc gaaacaggtt gaacgcgaga tcacggactt tagcaaagta 39000 gtggctcaat gcagttccct ccagtaccga tagtcactcc ttggtgtgtg tccgacttgg 39060 aaaagtatgc aaccgtaacc tggccatgac cgcggtcaca cactcatagc gaccaaggtc 39120 gatagcgtct ctttttacgc tggtgtcgac agtttgggtg ccgtgattac caaaggtatg 39180 tcctgccccg ctcgtctcag catcttgaac tgttctggag ctgtcggaga ttattggttc 39240 atgtcacttc ggtcggggtg gctgtctgct ggtagcgctg ttcgtatgcg actggtggtc 39300 ggtattggat tgatattgat gaggtggagt ctcgatcgtg ttgtactagt gcacccagga 39360 ggtggtttcc cgttccagtt cgacgcgacc ggtgaaggtc gcatgttggt cgattaattc 39420 agatttgtac cgtccctata gcagaatcca taaacacgtt gtccaaagcg tcgccgacac 39480 tgctgatgga tccggcgata ccggcctcgt gcagcgcctc ggtgaacgcg atcgacgtat 39540 attgatcccg cgtccaagtg atgaatcaaa tcggttatag agaatggagc tatgtgcaat 39600 agggggtgag tagcgtctgc tcaagcaccg atgtgaccaa gcacccgcgg tcttgctggt 39660 catcacctgc cagcccagga tggggtggga gaacacgtcc acacaaaacg tggtatggca 39720 caccctttgc agcgtccaca catatgtgca atcccttacc tgccactgat ccgggtaatg 39780 acagcattga gcaggaacga tcgagccggt cgggatgctg cggcggcgaa gacttgtcgt 39840 actcagtcgt acgaatgctg cacttattgc agcctacatc gtcaataccg gcgatacaca 39900 tcagccgtgt cgccctgtct ggacctcaac tgtgacctgc gtgtgtagtg gcgggctaaa 39960 gcctgtgcac acagtaagat cggtaggtta gccatccaca gatcaaacag gatcttgccg 40020 tcgtacgtgt cggtaagatc ggctgcccgc acaaaaccct gctgcttgac ggtgtagtag 40080 gtagacgggg ggacctgcac gtcagcctgc tcaaacatgt acatgacaga ttggatcgac 40140 ccgcattctt cgcggtggac attgatgtac tctgcaaaga attgcgcgcg aaaggatcac 40200 cgcagtcggc gatcgacttc cgccgcggtg aaaaacgcgt tcgctattcg cagaatctcg 40260 ttgacaagct tcaattcttg cacttcacgc tcacgctcgg cctaatcgcg cctctggcta 40320 ccaccggagc ccacctgact tctcccgcta tcctcgttgc cgctcccaca actcccgcga 40380 gtacttccac tgtgatgcca tccatactta ccctctccct gtacaaaaag cctccagcga 40440 aaccaagaaa caattcaaca tagttccctg cgtccttaca tgtagaacgc cttgtaaagt 40500 gttttatagg acacctgcat ctttcgggcc ggtcgggata ggttttgggc caacaccccc 40560 acaatttgtt cgggactgta cttcttggcc agcacacatg tctatctccg tacgcagctg 40620 cccacaacgc tcaccttgcc ggcctttaaa gccactggcc cactgctcac tgcatagcta 40680 agcaatacaa gctcagtaac ccgattgagc gtcttagcca gcatagttgg tgtcgaatca 40740 gtgcaacccc caaagcaacc cgcaaacacg cgggccccac ccttgctggt gatctcacgc 40800 acgatccccg cccccaccca acccaaacga acggttaacg atcgatcaca tcaactcaca 40860 acactgcaac acaccgccac cctttactcc acccccacaa cagaacatgc acacaaagta 40920 caattcaaca atcttgcaga tccgtctttt ccgcgtaggc caaccactcc aacgtcacag 40980 acttagactg gagcccggtt caagtactag cggggatata ggttaaatct agatgggggc 41040 ggacgctaac gtgctggtgt cttcatcacc agtatcggac taactgggac ctgacggttg 41100 gatagttgcg agcgtatccg ccgtcactgg tccaaccagc tcaactgctc cagctgcatt 41160 ttggcgatcg ggattggtgc acgcttgcgg ttatggtggc aactctcatc acggtactga 41220 gcgtaccgcc gtttggagtc atattggcga tcgattcgct tgtcgtgcga ttggggccga 41280 caccgtggcc gaggtagagg tcaacgctgc agccagttct ttggtgagtg tcgggcggtg 41340 ctggtcgggc cggcgttggt gggtctgacg ctaaaactgg tgggcatata ctggactttg 41400 tcctgtcggc ggtcgcctgc gccttggggc tggtgcggcg ctgctgattg tggttccact 41460 cgtttatgac ggatcctggg ccgagtaacg gaccagcgtc gcggactcgt ggctgatcgg 41520 cgcgagccga cctgaacacg gtcggaggcg gggtccatgc gaccctcgca acttctcggc 41580 cactgctgtc accccactgt tagtcgtcaa cattacagtg cttggtgttt ggtacgttgc 41640 gagcgcttcg gtggcccatg ggttgaggct cgggcagagg gtgtcacgat agtcatgaca 41700 ctcttcggtg ccggtgggcc tggtaaggtg ggcttgcgct gctatccatt gtcgagttac 41760 gccgtttggc acgtgtcctt ggccgggcca cttaataatt agatttggtg gttacgctga 41820 tggcgatcgg ggaggttgtt gtgcccgcgg ctggcttggc gttggctgcc tgtgtggggt 41880 tagtcggcgc tgtagcgtat gttccaccgg caccgacgtt agtgcagtgt tgccgtcgct 41940 gctgaagcga tggtgcccgc cacggccaac ctgcgaagcc tcgccgggga gacccggtga 42000 tcggttctac atgatcgctg cgggcgtggc cgacgacacc gttaatggcc gctgattggc 42060 cacgttgggg cttgatgttt aggttcgacg agatcgtctt gctgcatgac gtgccgtgct 42120 cggcaaccgt gacagcgcgg ggaccttgat ctgatcgctg tggatcgcga gtcgttccag 42180 cggggacggc atgtcgggta atagactcgc gcaacgtttt gtcatatctg ggtgatggtc 42240 gtgatatgaa ggcttagttg gtgaaacggt gtgtagtcga tggcctggtt aatggtctaa 42300 cgttgtttgc tgagtcaatt tcagtgacgt tgacagattt caatgtgtga gcggtgatgc 42360 cgacctacac tggttttcct agttgttttt cgatcgtgtg ccctgttgcg agaagcctga 42420 catgggctga agaatttggc ggggaggtcg ataacggtcc ttacaccacg tcggtactcg 42480 cgggtgctac ccggcatggg ctccgctgac tgttcgcctt agcccccaag gatcttatga 42540 aagaaactgt ttcagagcct ggccaagtcc tactgcgcaa tgtggtcaat aagaactata 42600 gagatgatcc tgcgaggaac ccaatgtgtg ctcaatcgtg gtaagccagg ctgcgtagta 42660 gacaacagga tattttcgtg gtcatacgga tgtctccgca actggatcgc cttctgtgcg 42720 atatgctagc tctaccagac gatctacagc ttcgtacgtg atgcgatgac tgggtcgcgg 42780 gtgctgtcgg cgatcgacat cgcagcgtag aggttcatgc tgtgggccaa tgccagcgaa 42840 atgtacatgt ccgaagtacg ctggaggcgt gtctggaact tattgaattt tatgccgaat 42900 tgcttgcgag tcttaaggga ataggtggtc agacaaagca acttcctcca tcgcaccgat 42960 agtttcggcg catagcgacg actggatacg gattatggcg tcgtgtatgg caggagagga 43020 gtcttgcacc tgagcggtgt tggccgagag gctaggttga ggtggattct agttggatct 43080 gatcgccgcg ctgactgtcg aacgtttgct aggaatgtct acttacggta ctaacgctga 43140 ttaggaacaa cccggtgctg ctgtctggca acgcggcgct ggccaccagc ttgtcggtgc 43200 agtcatgggt caagatcggg ttcttcaccg ctcaatttct atgaataaca ttgctgtaca 43260 acatgaatag cggcattatc ggtagacttt cggtaatcgg tctcaaggtg agtgaacgca 43320 agtagttttt ggctcgccgc gacctcgttc agcagttgcc gctgtgggtc attgccaagt 43380 tcggcgatca gtgctccagg tgctagtgtg cggtatgcac caacggttcg ggcgccaacc 43440 acagcccgat gtcagtgagc ataaccatga tttcgatctg gccttcctaa gattggtaga 43500 agccctagcc ggggtatacc gacctcgggc gagctgattc cggacatcac ggctccaact 43560 aagctcggta tcgataactt tgttgcagct ctaagatcat agttgcacga aagtagatca 43620 cgggtggtct tgatgagcag aagctgttcg ttgttcaatt gaaagtccat ggattctttg 43680 caatccgaga atgtttgacg cgatgacatt gcgctgtact tcgttgctgt cgccgtagat 43740 cgatgtcttc cagtagttga gtatagcgcg aggcgttgga ctgctctccc agtcgaggga 43800 ggcgatattt tggccgcagt cggtctacaa tgcatagggt ccggccacct agaccaggag 43860 ttcggtcgtc acttgttgca cttggctgtc gcgcagctcg agtaccgatg acgccgggtt 43920 aggcttgccg tccgcagagg tctgagacca cctgtgcttt agggatttcc agagccggaa 43980 cagtattttc ctacttagct actcgcgccg tgaacaacgg atctcccaac aaatcggtct 44040 gtttggcgtg cttttcatct cggcgaagtg cactttgatc ctgctaacag cggctatgtc 44100 gatgcgctta ttactgagca ggaattttgc gtaaacctag ccttggttct attgtccaac 44160 aagctaatcc ggtactcgaa cgtcggagaa aacaccttgt tgacttcgtg gccctcatcg 44220 atcgtcttga ccggccggaa agatcatgct tggtgtggct atgtttatga gtaaaaaatg 44280 agatgttaga ataacatttg agtacttgcg agtcggtacg catcgtgcag aagatctagt 44340 ccgcgtacta ggctgagtgt tgtccacgtc ttttgtccat tgacgacgta gctgctgccg 44400 tcgcccacca cggttgtgcg cagtgaggca aggttggagt cgacttcagg ctccggcact 44460 cctggtatca ccagatatcg atgctgacgg tcagcggcag aaagcgctgt ttgagtttct 44520 gggatccgaa ttcggcgatc accgggccaa ccatcttggt gttgaagttc cgtggtgctg 44580 ggcacatgcc aactgcatct cgtcaggtcc agatctggtg ctgggtgggt gttcagttct 44640 tgctgcccca cttaaccgac caattcggta ctgtgaactc gtgatcgttg agaatcttct 44700 ggctggtgac gatctggttg tggctcgtcg cggagccctg gcgcatcagc gcgtggatcc 44760 cgtcagggat ctgcgtaggt gtagaaatgt gatgagctgg ccacgcaaag tggcttgatt 44820 agtggtcaat gccagtttca tggcaacctc acggtgtctt gaaacatttc cgatcgaaga 44880 cagtagtgcg ttcggcactt agtcgttcac cccgaacttc atcttgactc atttcgtgct 44940 caatctgtac atatagcctt ggttaatcta caggtgcgag ccgcggcagt gttggtcgcg 45000 atcagtattg tcgccacccc gcttactgtc ggctcatgcg aacagaattt ccccactcag 45060 caactgcatt ggtggttggt ggctgtttcg cataccgatt tgctcgctaa cgctgatgcg 45120 atcgaagacg ctgacactcc ctaattcctt gcttccccgc cgggttcccg acgcatccaa 45180 tggcacgggc tggatagcca gggccacagt ccgcgccgat tccagacgtg ctggcgccat 45240 cgcattagcg gtggtggtgc cctcgcggtg ttgatcactg tgttcacctc gatgctggac 45300 cggcttgcat cggtgatgtc agcgaagctc cccggtagaa aaggttgtgt cggtaacccc 45360 tagagcgttc acacgtacgg gtgccggaca gccagctggt cctgatcggc cggtggtggt 45420 tcagcgtggt tggtctggtg catacctctg ggctagtcat gctggtgcct gacgtgtgga 45480 tcgtcgatgc ggggcagagt ctgtgggcgg tgcggacacc atcgggttgc acatggctcg 45540 ttcgctgggc gacggagggc agatcgttgt tgggttggtc tctcttcggg cagccgagag 45600 tgctaagcag cttgatgatc tcgggctcag ccacgccact ggaatcaggg ctgtcatcgg 45660 gatcggtcat gtagaaggcg aatgagatgc ttgaccacaa taccgcgacc gtgcagcagc 45720 tggacgctcg gttcggggta ggactggtct ccgtcgtagt gattgtggcc tggcggcagg 45780 ccaacggcaa gttcatttgc gtttgtttac cagctcgtcg gtgttgatgg cgtcggttcg 45840 gcgcggctag aggagggcct atgtgctctg gtccgtgttt gacgcctgtg tgccacctcg 45900 gccccgtgga atccgcggtg gctccggttg atgtgctcct ggttccgaca gctttcacca 45960 ggtgggtcgt gactgctgtt ggtatgctat ggctgatcta ctaaacttaa ccgcgtggct 46020 tcggctaatc agcaccggcc tggtggcgat cggtatggtt ggtgtggagt gtgggctaac 46080 gaccgcattg cgtgcaaaca cggtgagtca gcacccgatt atcgcagttt tcggaacacg 46140 cttcggtgat ggtcatcccc aaggaaagtg cggtgtcggt gggcccaggt ggtcagcacc 46200 ggctcatgtt tcgcgcgacc ctataggctt cgcgccgaag agatgtcggg ccaggtaagt 46260 ggctttcgcg ccggacatcg gactttcggc tcgcaaaccg ccctcgaaac caacacagtg 46320 atggttggcc agccggtgtg gttcgctgcg agtagcaccc gcctggccag ctatgatctg 46380 atctgacggt ggcggtcctt aacgctacag gcattacgca cttgacggcg gtatccgggg 46440 acaacgtgac ggtcgtgtgc gcggcggtgc tgttctcggt ccggctgatt ggcccgcgcg 46500 tggccgtggt gttcgtggca gtggcactgt tggcctttgt gatcatcgaa cagcccacag 46560 ccagcgtgct gcgtgcggcg ccatcgtgtt gtcacggcat actgtcttcg ctttggcgat 46620 aaacgattcc cacgctgttc gccactgcgt tggtcttgtt agccgttgtt ccttcacctg 46680 gccgttgacg tgaacttcgg gctgtccgtg ctggccaagg ccctactggt agtcatcgcg 46740 caagtctggt tacggcactt ggtcgcgcgg aggtgccccg agtcgctaac cgatgccctg 46800 gccgtcgtgt gggccacgta cgtggttacc gctccactgg tgctggcgtc ttggcccggt 46860 tcagccttgt taccgctgcc gccaatctcg cggtggtggc tgtgataata gcaccgatta 46920 ccgtggtggc tgtgttatgc ggcctgtgtg cctgcggcaa tcgttcccgg tccggctagt 46980 gccctcggcg tgctgctgct ggtgttggtc ctgtggcggt gctttcgggt ggcgatgatt 47040 tcagcactga tggtcgccgt tgcgtgcttg cctgattggt tgtcagggtt cctgaccggc 47100 gggcttatcg cgggctcgtc ggctcgtcgt gccaccatct acggagtgag taataagttt 47160 tcgtcgctgc acttggtcct aggaaatgag gaactgctgg ttgagcgggc cgtgggggag 47220 gtgttgcggt cggcgcggca gcgggcaggc acccaggacg tccccgttag ccgaatgcga 47280 gccggtgacg tcggcaccta tgagctcacc gaactgctga gcccgtcatt gttcgccgac 47340 gagcggattg tcgtgctaga ggccgccgct gaagcgggta aggaggccgc tgcgctgatc 47400 gtgtcggctg ccgctgacat accgcaaggc acggtgctgg tggtggtgca ttcaggtggt 47460 ggtcgagcca aagcgctggc taacgagctg cagtcgttgg gtgctacggt gcatccctgc 47520 gcgcggatca ctaagcttag cgagcgtact gattttgttc gaaaagaatt gcgttcgttg 47580 cgggtcaagg tcgacgaggg ggcagtgacc gccctgctga acgctgttgg ttctgacgtg 47640 cgcgaactcg cttcggcctg ttcgcaattg gtagccgaca ccgccggtga tgtcgacgcc 47700 gacgcggttc agcgttatca cagcggcaaa gcggaagtga agggctttga cattgccgac 47760 aaggcggtcg gtggcgatgt ctcaggagca gtggaggcgt tgcggtgggc gatgatgcgc 47820 ggcgagccac tggtggtgtt ggctgatgcg ctggccgaag cagtgcacac gatcggccgg 47880 gttgggccgc tgtccggtga ttcctaccgc ctggcgtcgc ggttgggaat gccgccctgg 47940 cgggtgcaga aggcacaaca acaggctcgg cgttggtcgc gtgacacagt ggcagccgcg 48000 atgagagtgg tggctgcgct caacgccgac gtgaaagggg ccgccgcgga cgcctactac 48060 gctctggaat ccgcggtcag gaaagttgct gagctggccg ccgatgggag ccgatgagtt 48120 gcagataatc gtcagctgcg gccttagctt ggctcagagt ttgttgagag tacgagccag 48180 tgccgacttc ttgttagccg cctggttctt gtggatcaca cctttgctgg ccgccttgtc 48240 caatttgcgg ctggtcgaca ccagcagctt cgctgccttc tccttctcgc cggcatggac 48300 cgcctcgcgg aacgcgcgga cagcggtacg aagcgaagac ttcaccgact tgttgcgcaa 48360 tctggcgcgc tcgttggtgc ggttgcgctt ctgctgcgac ttgatgttgg tcacgcgtta 48420 aattcctttg tcgatttagg cgcgagtgct cttctactct acggcgacaa acttttagag 48480 taccagtcgg ctacgctttc tcacaaaagc acaactttgt gctgctggaa cggacaattt 48540 gaggcagcat gtctcaggtg agtcttccca gccagctcaa ggagactgga ccacggttgc 48600 agtctcgttg ccggtcctcc gcccggtctg agcgcatttt cggtgggtac aacacctcgg 48660 acatctattc aatggccttt gacgaaatgt tcgatgttca aggcaatgtt cgtggtccgt 48720 acaagggcat ctacgctgag ctggcgccgt cggatgcgtc cgagctgaaa gctcgcgccg 48780 aagcgttggc tcgcgcattc atagatcagg gtatcacgtt ttcgctgtcg ggtcaggagc 48840 ggccctttcc gctggacttg gtgccgcgtg tgatctcggc atccgagtgg agccgattgg 48900 agcggggtat cacccagcgc gtcaaggctc ttgagatgta cctagacgac atctatggcg 48960 atcaggaaat cctgcgcgac ggcgtcatcc cgcgccgctt gattacctcg tgtgagcact 49020 ttcaccgcca ggcggttggt attatcccac ccaacggcgt gcgcatccac gtcgcgggca 49080 tcgacttgat tcgcgatgac agcggcaatt tccgggtgct cgaggacaat cttcgctcgc 49140 cgtccggggt gtcgtatgtg atggagaacc ggcgcaccat agcgcgggtt ttcccgaatc 49200 tttttgccac ccatcgggtg cgagcggtcg acgactacgc ctcgcatttg ctgagggcgc 49260 tgcgtaactc ggcagccacc aatgaggcag acccgacggt ggtggtgttg actccggggg 49320 tggccaacgc ggcttacttc gagcactcgt tactagcccg ccagatgggt gtcgagttgg 49380 tcgaaggacg tgatctgttc tgtcgcgaca accaagtata catgtgtacc accgaggggg 49440 agcgccaggt cgatgtcatt tatcggcgta tcgatgacgc ttttctagac ccgttgcaat 49500 tccgtgctga ttctgtactg ggggtggccg gattggtgaa cgctgcgcgc gcgggcaacg 49560 tcgtcatctc gagtgcgata ggaaacggtg ttggcgacga caaactcgtg tacacctacg 49620 tgcctaccat gatggagtac tacttacggg aaaagccgtt gctggcgaat gtcgatactt 49680 tgcgctgctg gctggatgac gaacgccaag aagtgcttga ccggatccac gacctagttc 49740 tcaagccggt tgaaggttcc ggcggttacg gaatcgtttt tggtcccgat gcctccgaga 49800 aagagctcgc tgctgccagt aaaaagattc gcgacgatcc ccgaagttgg atcgcgcaac 49860 cagtgatgga actctcgact gtgccgaccc aggttggtag tacgctggcg ccgcgttatg 49920 tcgacctgcg gccgttcgca gtcaacgacg gcaacgacgt gtgggtgctg ccgggtggac 49980 ttactcgtgt tgcgctggtc gaaggttcgc gggtggtcaa ctccagtcag ggcggtggct 50040 ccaaggacac ctgggtgctg gcgccgcatg cgtcgtatgg cgcacgtgag ctgggcgccg 50100 ctgaaatcgt gtgttcattg ccgcagtcgt cgcccgaccc agtgcccgac ggatcgccgc 50160 gaccaaaaca acagccgcag caagcgcaag ccgagcaagc gcagcaaccg caacagcaga 50220 taatgttgcc ctgatgcttg cccgtaacgc cgaggcgctc tattggatcg gtcgctacgt 50280 cgaacgtgcc gacgacaccg cgcgcattct cgacgtcgtt gtgcaccaat tgttggaaga 50340 ttccagcgtt gatcccgacc acgcctcgag gacgttgctg cgggtgctcg gcatcgagct 50400 cccggaccac gagttggacg tctggtcgct gaccgatctg gtggcgttca gtaccaatgc 50460 tcagggcggc tcttcgatcg tcgatgcgat ctcggcggcg cgggaaaacg caaaatcggc 50520 acgggaagtg acatccagtg aaacctggga atgtctcaac accacatacc atgctctcgc 50580 cgaacgcgaa cgcgccgcta aacgccttgg tccacacgaa tttttgtctt tcatcgaggg 50640 tcgggcggcg atgttcgccg gcctggctga ctcgacgctt tcgcgtgacg acggataccg 50700 cttcatgctg ctgggccgcg ctatagagcg ggtcgacatg acggtgcgac tgttgttgtc 50760 ccgggtggga gatagcgcgt cgtcaccggc atgggtgacg ctgctacgct cggctggtgg 50820 gcatgacacc tatctgcgca cctaccgcgg tgtgttggat gcagcccggg tggtcgaatt 50880 catgctgctc gaccggctgt ttccacgttc gattttttac tcgctgaagt tggccgaaca 50940 caaccttgac gagttgttgc gcaatccgca gagccgagtt ggtgccacaa cggaagcgca 51000 gcggttactc gggcaggccc gcagcgaact ggaattcgtg caacccggtg tgctgctgaa 51060 gacactggac agccgcttgg ctagcctgca gaccacttgc agggatgttg gagacgcatt 51120 ggtgttgcag tattttcacg tcgcgccgtg ggtagcgtgg tcggatgccg gccaccgggg 51180 acgaatggtt ggcaagcggg gagaagcctg atgtggcgga tgcgggtggt gcacagcacc 51240 ggatacgtgt acgaatcgcc ggcgaccgcc tccttcaacg aagcccggct gacgccgcga 51300 tctaatacac ggcaaaccgt catcctcaat cgtgtcgaaa ccattccggc cactcggtcc 51360 tatcgctaca tcgattattg gggtaccgtg gtgacagcgt ttgacttgcg cgcgccgcac 51420 accgagctga cagtgacgtc ttcgtcggtt gtcgagactg aaagccttga accatcggtg 51480 agccggatca cctggactga actgcagtcg atggccgtaa tagaccgatt tgacgaagtt 51540 ttgcagccca ccgcatacac cccggtaaac actcgtgtag cggccgtcgg caagcggatc 51600 gccaagaatc acgaacctcg gaaagccgtc gtcgccgcag cccggtgggc gcgaagtaag 51660 ctggactaca ttccaggcac taccggtgtg cattcgtccg gtttggacgc actgcaccag 51720 tgtaggggag tctgtcagga cttcgcgcat ctgacgttga ttgtgttgcg cagcatggga 51780 attcccggtc gctatgtgtc agggtatctg caccccaaac gcgacgcggt cgtcggaaag 51840 acggttgaag gacgcagtca cgcctggatt caggcctgga cgggtgggtg gtggaattac 51900 gatcccacca atgacgttga aatcaccgaa caatacatca gcgtaggtgt ggggcgcgat 51960 tacacagacg tggccccgtt gaagggaatc tactctggtc ggggggcaac cgaccttgac 52020 gtggttgtgg agatcactcg gttggcttag tcgcatgaat gattggtcgg cgcaaagaat 52080 caacagtgct ggtataacca aggcgctgcg gagtcgactt atgcccggtc ggggactggc 52140 ctgcatgggg tggctgttcg gtggacttgc tctcggcgtc gcgctgggct gcgtgatccc 52200 attgtcctac gggtcgatag ctggggttgc ggtcatacgc ttttgccgaa cccaatcgtg 52260 gtgcaagcta tagccactag tacgtttgcg tcctcggcgc cgctggcgct ttacgcggct 52320 atggtcagta tccggttgtg tcagttgggt agcgaccgcg tctgccgccg tgatagcgtt 52380 aactggcggt gtcttgactg ccggcgcatt ggtgctgacc ggattgttgg tctacccgct 52440 gtcgcaactg gaggtcaacg cggacattgc gctggttcgg gcgagttcgt tgctgatatc 52500 tctttctggt tggcagccca gggcacctgg tggtgttggg tttgctggtc gccagtatgg 52560 cgtacccagc ctaatgcggg gtctcatgcc cagatcattt ggtatgtaca ggcttggcgc 52620 tcgccgcaga aacaacactg gtgttgatct ggccgactgc cgggtgcgga tttactgtcg 52680 gtcgtacgcg tcgctgcgtt gttccggctg atagaggtcg gcacgctatg gatgcttgcc 52740 aaccccgatt cggtgtaggt cgttgtcaaa cttgatttgc cagttgaacc tggacacggt 52800 cagctctcgt caccgtttct ctttccctag ggacatagta cgttatgacc aggatgccta 52860 tgcccgcgtg cgccgcggtt gctgtcgctt gctcgattga cgagtggggg ttgcagatgt 52920 ccttgatctg cttgttggtg aacgcggatg acgatgttct tgcggattat ggtgtgcacc 52980 aatgcgtcgg cctcggcggc aagctcgtcc aggctggcgc agggaaccgt gcctccggtc 53040 agcaccaccg aggtcggtcc ggattcgatc cggaatccga tcgtcggcgt cacaggcccg 53100 tgattcgtgg aaccccggat cgacacgcca tcgggggggg ctccaacaaa acctttggtg 53160 tattcgtata cttcgatcag tgggggcgta ttcaggtaag tgtgatgggt gatctgatat 53220 tcgatgtcgt gaccggacgc cttcagcttt gcctctaccg tttcagcggt gtccggagat 53280 ccgatgatcg gcagcggtgg gggatccagc gcgaaggtgg ttacccaatg cgtgatgagc 53340 agatcgccaa ggtcgctgat gcggtcgccg tgcagatgag ttgagcagca gcgctgacaa 53400 acagctggcg tgtgcgtcgg accagccgac gcacgttgca acactccaag ccagcagtcc 53460 actaggaaca gctgtctgcc agcttgcacc gcgtcgagaa ggccggcgcg ggtcgggtcg 53520 ggaatagggg acttccggtg ctgagcagtg tggtctcgat catggtccca tccttgtaac 53580 tagacgggtg cgcagtggcg caatttattc attcggttgg tgagcaaggg tttcggcttc 53640 tcgacgtggg cgagatgctg gttgtcgacc tgaacgttcg agcgttattg gtggtgtgtt 53700 ttttgtcgac tttcccatca gccgagttag ccgtagcctg gtgtcaagga gatcataact 53760 ttcggctgga ggcctagatg cagatcgcgg gcgtcttacg gagcaagggt gcgacggtgg 53820 tgacgatcaa tcgtgacgcg aatgttcggg aacggatcgg ccggtcttgt cgagcagaac 53880 atcggtgcca tggtggggtc ggcatcggtg tcggagcgta acatcgtacg tcagcttcat 53940 gcgtatggcg tcagcgtgct gtcttgcccg atctccaaga ttatgactag cgttggttgc 54000 cagctgccgc tggtcctgtc ctatatcact caaggttaac tgcgcggctc agcgccagga 54060 ttagtcggca cgcagcgggc tggctatggc atcgaagatt tcacgtttca agatcgtgtc 54120 ctcgtggcga atactctcct ccggcacgtc gaacacccgg tctagccgga tccagctttc 54180 tcggttttcg taatcccaac tgctagaggc cgatgccaac ccaatcttgg taggctgcgt 54240 ggcgttcttg gctggacacc atcagtccca atacaatatt gttgttgcgg ctcacgacga 54300 ggaccggtca gtcttggctc cgggtcgggt cgtcctcata tggaggaccc acttccacgc 54360 gattttgcag gattagctcg gccatccagg tcaggggggc gtagagtagc tcacgggttc 54420 gctgcgcggt gggggagggg aactaagcgc ttgccactgg ccggcccgcg gtaatcgcga 54480 caggtggttt tggcgcagct gcggctatac acattcacgg tgactttgat ttcatgctgg 54540 agttcccgca gcacggcttg cgaattctgc acgtgacggg agaggtgtgg agtccggctt 54600 aataccatgt tcttggttct tggcaagccg ttgtaatgtt ttccactatg actgccaggc 54660 tgacgccata ttcgcagtat aggaccgaaa ggcccggcga gattgctgtg ccagtgtgtc 54720 ttggtcactt cgcgtggata agccggacac cggcgaatcg ccgttcaaac attctctagt 54780 aactggagcc caggagattc ccatcagcag tttcgctgac aagaccttta ccgcgccggc 54840 gcagattagg aacttctgca taatcgctca tattgatcac ggcaaatcca cgctggcgga 54900 ccggatgctt cagctgactg gtgtcgtcga tgagcggtcg atgcgtgccc agtacctgga 54960 ccggatggac atcgaacgtg agcgcggaat cacgattaaa gcgcagaacg tgcggctgtc 55020 ttggagtgtc acagctggtg ggacgactga gaattatgtg ttgcacttga tcgacacccc 55080 cggccatgtg gacttcacct acgaggtatc gcgagcattg gaagcctgtg agggtgcggt 55140 gctgctggta gacgccgtcc agggcatcga agctcagacc ttggccaatc tctatctcgc 55200 tctggagcgt gacttgacga ttattccggt gctaaacaaa atcgacctgc cggctgccga 55260 tccggaccgt tacgccgctg agatcgccca catcattggt tatgagtcag gcgatgtgct 55320 tcgggtgtcc ggcaaaaccg gcgagggggt ttctgacctt cttgacgagg tggtccgtcg 55380 ggtgccgcat ccgcaaggtg accctgatgc gcctacccgc gcgatgatct tcgactccgt 55440 ctacgacatc taccgaggcg tggtcaccta cgtccgtgtg gtcgacggca agatcagccc 55500 gcgtgagcgc atcgcgatga tgtccaccgg tgcgacgtac gaactgctcg aggtcggcat 55560 cgtgtcgcct gaaccgaagg ccagcgcggg cctgggcgtg ggggaggtgg gctacctgat 55620 tactggggtt aaagacgtcc gccaatccaa agtcggcgac actgtaacga cggttcgtta 55680 tggtgccact gaaccgttaa ctggctaccg agaacccaag cccatggtgt actccgggct 55740 gtatcccgtc gacagttcgg actacccgag tttgcgtgac gctctaggta agttacagct 55800 caacgacgcg gcgctgacct acgagccgga aacatcggtg gcgctgggcg ttgggtaccg 55860 gtgcggcttc ctcggtttgc tgcacataga tataacccgc gaacgcttag agcgcgagtt 55920 cgacctggac ctgatctcca cgtcgcccaa cgtcgtatac cgtgtggtga cagaagataa 55980 caccgagatt gtggtgacca acccgtcaga ctggccggag ggcaagatcc gaacggtgta 56040 cgagccagtg gtgaagatca ccatcattgc gcccagcgag ttcatcggaa cgatcatgga 56100 gctgtgccag tcgcgccgtg gcgaattagg tggcatggac tatctttcac ctgagcgagt 56160 cgagttacgc tacattatgc cgctcgggga aatcatcttc gatttcttcg attcgctgaa 56220 gtcacgcacc cggggctacg ctagcctcga ctatgaggag gctggcgagc aggaggccca 56280 actggtcaag gttgacatcc tgctgcaagg cgaggccgtc gacgcattca gcgcgattgt 56340 gcacaaggat tcagcctctg cctatggcaa caagatgacc aacaagctca aagaactgat 56400 cccacgtcag cagtttgagg tgccagtaca ggcggctatt ggatcgaaag tcattgcgcg 56460 cgaaaatatt agggcgatac gcaaggatgt gctgtcgaaa tgttatggcg gcgatatcac 56520 ccgcaaacgt aagcttctgg aaaagcagaa ggaaggcaag aaacggatga agaccattgg 56580 gcgggtcgag gtgccgcagg aagcgtttgt cgccgcgttg tccgccgatg ccgcaggaga 56640 caaggacaag aaataacctg ttcgacttta tgttgacgaa ctgaagcatc aaaagattgt 56700 tctgcaagca cattcaatat ttaagcgtgc atactcttgg cgcattcggg tgctgtaaca 56760 tccccgcgtt gtcggcttcc ttgtcggcgc ggatcacatg gaccacttcg tttatcaacg 56820 ccagacgggt gaacgcctcc ggggagttgt ccaggtgccg cccggtgcgt ggctcgattt 56880 cttcagcgta gaggtgcagt gggctcgtgt aggaaaacag tcgcttagcg caggttacct 56940 caccgatttc caccagcgcg gacaccagcc agaatgatta aatggtgagc atgttttctt 57000 cgccggataa cccttaattg gtttctttta tccggtatcg cagcactaga ctctcttcgg 57060 tgagttaatt ggcgacagcc agcccagtgt taagcacgcg cgggtcgtca ggtgccagga 57120 atctggtcag tagcactagc aacagtgagg aatccaacgc gtcgttgcca taccgctggg 57180 tgaatacgtc gcggtagtcc atcccatgct cgagaatctc ggtcttgatc tcttcagcga 57240 tggccagtca ctgttgggtg cgtttttctt accctaccgt tcggttagct tggcctcgcg 57300 gtccagagcc atccaacaca tcgtcccaac acatcgtgaa gtgttgcggc tcgccgcgaa 57360 tctcccagat tccgcggtcg ggctcacacc agtgcgcgat cacctctttc acctgctttt 57420 tcaatactgg ctacaatatt tctgagattt tctcgagcga cttggtgtgc agaagaacga 57480 gtccagaatc cagccctaga tatcgtgctg aacttggtcg taggagtcgt ttgccgattc 57540 gcaccggccg cgcgtggtcg tagccgaaca gatgatataa tccgtcttca accaggcggc 57600 gttcgtcgcc taccatcacc tgcagcagat ggcgctggtc gttattggcg ccggatacat 57660 tgacgatgta tgcggagaag tcgtcggttt cgtggtcgag tcccagggtg taaagccccc 57720 cacaacgcga acgttgaatc gctcacccag gtatcgtggt actcccagtt gcgttcgctt 57780 tgtgacgttt ccggaagtga cttagtgctg ccgggccgtt agccagcgcg ccggtgggag 57840 gatacgggaa cctgttgagt gttagcgtgc tgtattacag gtatgcccgc gacgggtggt 57900 cggggaagtg gccgatgttg atccactgcc gccagcattg ggtgacctgt cacatcttgt 57960 ctgctgcttc tacataggtc tgtgggaccg ggtgtttggt ccagcttagc gtgacgaaca 58020 cgtcgtcgcc ctatttcatc cggatgcgtg cccgtgtttt acggatctcc aacctgatct 58080 gcatattcat attggtggtt aaccatggcg ccgggtggat gtcaggttgt ttgctggcat 58140 gtgtgatggc ttcgccgtag gcatgggtca agtattctca cacggcgccg atgcgatggt 58200 agtcaaacgc cggctcgcag ctcatcatca gctcaacggt gccgcttatg cagagcaccg 58260 tgcacagcag gatgtgcttg gcgtcctaat ccatcgtgat gcgttagtga tcggcgctcg 58320 atgtcatggc catgtccccc ataaccggca cgttccgcac gattaaccat ccggtgtgtg 58380 gtctgccatg tggtttccat gatcaagctg ctgggaaata gcggcgggtc gacggtaccg 58440 aggccgccgt aggggcccaa tcggaaatgg ccggcgcttg ttagtccagg atcgcttcga 58500 acacactcgg agagtcaggc tggggcagcc tatactccat agacattcca ccgaaacggc 58560 cgacgagatc aggcacgtcg tttcctagtc ggacaagaaa tgcgtagtca gcgatcgacg 58620 gaaacgggtt gcgtagcacg ccgctggagg caactagcgc ctgcgagttg aaatcgaaag 58680 gcgcgggttt ggcggcttgg gctgcggtaa acactgctag ccgcagcagc cttgtcgtcg 58740 gctttggcgg gttgatagga ggggggcggc gtgcaggacc attccgccat aatctgtcga 58800 ttcttcctgg tgtccatcgt ttgcttcttt gcccgagggg ttgtggtctc tacccggcgt 58860 gcctggcgta cttaggcatg ttgttcggat aacaggccaa tcgcgaccag gtaaccgacg 58920 aaccgtcgca atgccagtgt tcggctcacc atccgagcct tttgcggtgg tgtttggtca 58980 ctgctgtcca ccgcgacagc gatgatgttg tcatggataa cccggtgtgc cgcctacagg 59040 atagtcgtcg gaatccagtg gcgtagctgt actcgaacta gctgccaggt tgacacgcgt 59100 tccgtacaca gaggacaggt cagccgggga gcggccgcta ccactaggtt tatgcctacg 59160 ctggccaccg cggcatcacg tgcgcagcgt cgtttatgta aatgatggcg gtgatttatg 59220 tatgtattat tatgtagtcg ccgctgtcga tcgtgatcgt agtgtgcccc gcgtgagtat 59280 atcggccagg ccgaacgggt cgttgggccg gcgaggcaat cggaaccacc acacgttcat 59340 cggagcgccg aagctacgcg gtgtcagtgc tattgctgag cgcatggtcg acggggcggc 59400 catcgcaggc caccgctaag tcggtgcgta tgatcactta ggtcaccgcg gtgctgcaca 59460 taagtcggaa cgtgggctcc atctcggcac cggcagccat tatctccaga aagttccact 59520 gcggctacca ggatgatgcg ttgatgtgtg ccgagcaggc ggctcaggtc cagattgact 59580 cacttgccct gtatctccat ctggatggtg tcgattttgc gatgcagaat ttgtgcgaat 59640 aggtgggtca cagatcgagt tcgtcaagta gccacaaggt gcttgcgggc catggcaatc 59700 ggatcgctgg ccaaaagcag gccaagcatc atgctcgccg gtccgcctcc agcaatgagg 59760 catgtagttt tgtcggatgt ggaaggcacg gacagcattg ggcgatcttg acacagtgtt 59820 ttacgatgcg gggacggcga atgggacgaa tgggattagt gtgagcccgg tgaacgggtt 59880 cctgaattgg tgggacagca tcgagctttg gctgtcaggg ctcgccttcg tgttacaggc 59940 ggctttggtt atgccggttg tccttgcgtt tgcctacggc accgcattag tgttagattt 60000 cgcgctcggt aagggcatcc agttgatgcg tcgagcctat caccctgatt cggcgcgcgg 60060 gtaacctgaa tgcctcggtc acatgttacg ttggtgctgt tcgttctagt ggcgctggtg 60120 atagtggcgt ggctgctgac gcgctgagta gcattgggtt gctaaccagc ttagctgtga 60180 tggggcagcc gattctgtta agttttgcgc catgcacgta gcacccggtg tttgggagtg 60240 ctgtgtcctc gtggattatt gttgctgact ccaaaacccg tgcgcggtct ggtacggagt 60300 tcgtgaattt tccctagttc taggtggccc ttgcgtacca acgggattga gatgcctacg 60360 ttcctcactg gaaggcggct aatgtttaaa gacattgggc gattcatgcg ctggcggcac 60420 tcgatggtcg tcggggtcac gcttgcctcg accaccgatg tggttgctgc gtgtcatggt 60480 ggtgccagtg acgtcgttgg cggcgggacg gcccatgcgc atacgagtat cgccctggtc 60540 gcttactcgg cgccgggacc tggttggggc aaagtgattc cggcgtttaa tgacgctcgg 60600 tcgggcgatg gtgtgcaagt ggtaacgtcg tatggagcct ctggcgacca gtcccgcggt 60660 gttgtcgatg gcaagccagc tgacatcgtg aatttctcgg ttgaaacgga catcaccaga 60720 ttggtcaagg taggcaaggt gtccaaggac tgggataccg acgccacgaa gggcatcccg 60780 ttcggatcag tggtgacatt ggttgtgcgc accggtaatc ccaagaacat caaagattgg 60840 gatgatctgg tgcgccccgg tgtggaggtg atcatgccca atccgcttag ctcgggctcg 60900 gccaagtgga atctgcttgc tccgtacgcc gccaaaagcg aaggttgccg caatagccag 60960 gcggggattg attttgtgaa ccggttggtg gccgaacacg tcaaattgcg gctaggatct 61020 gcgcgcgaag ctaccgatgc ctttgtccag ggcagcggcg atgtgctgat cagctatgag 61080 aacgaggcta tcgccgccga gcggcagggc aagccggtcg aacacatcaa cccgccggtt 61140 accttcaaga tcgaaaatcc gttggcggtg gtgagcacca gcgcgcacct cgaggtcgcg 61200 accgcgttca agaacttcca atacaccact gccgcgcagg ggttgtgggc gcaggcaggt 61260 tttcggccgg tggatccggc ggtcagtgcc gatttcagcg accaattccc ggcaccggtg 61320 aaactgtgga cgatcgccga cttgggtggc tggagcacgg tggatccgca gctattcgac 61380 aagaacaccg gtagcatcac caaggtctat atgcaggcca ccggatgacg gctcgttaat 61440 cgatactcgt tcgttgtgtc ggctcggtac taccacgtag cttggggttg gtgcggcgat 61500 agtgtgggct ttcggtgatc gtgctgctgc ccttggctgc cattgtgtgg cagaacgccg 61560 gctgctggcg ccctttcctg tctggtggtc acatagcacg ccgtgatgga ctcgctgcgg 61620 gtagatgctg accatctccg ctggggtttg cggtaatcaa cattgtattc gctctgctga 61680 ttctttgggt gttggtgcgt gatgacttcg tcggcaagcg gtcggtcgat ggcggtatcg 61740 atgtgtagtt tgcgttgcct acgattgtcg ccagcctggc gatgctggct ctgtatggga 61800 acaacagcct ggttggtctt catctgcagc acaccggatg gggcgtgtgg gcggcgctgg 61860 cgttcatcac gttgccgttc gtagtgctta ctgcctaatc ggtgctgttg gagatcagtc 61920 cgggcggcca aagagtcggt ggcgtcgttg ggtgccagca gtccgaaaaa tcgttatctc 61980 ggcggttgtt ttgccgtcgg tgactccggt gttgttatca gttgcgggcc tggagttttc 62040 gcggatgctt ggcgatttcg gtttgatggt gctgattgat ggtccggtga cgaggaagat 62100 atcagtgtca tcgtagtgga ttcctgacct tgatcgagaa tcacgaccgc actggtgcta 62160 ccgcaatata gattgcactg ctgtcgatct cgtgtgtcgt gctcttttta ctgcaggtcg 62220 taggcgcgca tgaggactga tgcgaggaga tagccacatg gcgacattgc cgcaagttag 62280 ctatctgatc ctgtatgtcg cctttgccta cattgttgtg ctactggtta tgacgtttgc 62340 gctgatctta tggcggacct ttgcaccggg cttcggtcaa ttctacgcct gagtcagcac 62400 gtcagaggag ggattggcgc tgaacttgtc gcttctggta gtggacatcc cggttccgct 62460 gaacgtggtt ttcggaattc cgacgacatt ggttttttta tcaacatatt tcgacgaaaa 62520 ggtgcactgc agacgatcat cgatctattg ttagcggtct catccgtcat agtaggtgtt 62580 gcactggtcg tgctgtgggg atcgtgcggt gcgctgggct tcgtggagaa aggcttggag 62640 ttaacgatca tctttggcct gtccggcatc gtgcttgcta gcgtcttcgt caccctgccg 62700 tttgtggtac gcgaggttga accgatgctg cactaactgg ggtccgacca aaaccaggtt 62760 gcggcaatac gaggatctag ctggtggcag aaattctagc ggattatgct actcttcaac 62820 cggcggcacg tagcctacgc cattgtgtta accgttgcct gtacgttggg tgaatatggt 62880 gcttatgagt tgttaacttt gttgattacg gtatccgcgg tggtcttttg agtatccagg 62940 tgggttttga ttcctgccgg gtacgagcag gcagaaacgt ctgactaagg gacgtggaga 63000 tggccgatga agggactggc caggacacgc acaacgatca tcgtgcgcga acgtctacaa 63060 actctatggc cacttcgtgg ccttgggcca cgtggcgtca tcgtgcccgc cagtttgctg 63120 atggcgttgt tggggcctag cggttcgggt aagttgacgc tgctgcgcat catcgccggc 63180 cttgaccacc cggacaccga aaccatcaca atcacggtcg cgacgttacc caggtgctgc 63240 cgcaacgccg cggcatcgtt tgacattatg ttgtctttga gcacatgact gtgcgcgaca 63300 atgtggccta agggcttgag attcgtaggc gccttaaggt cgatctggtg ctggctcgag 63360 ccctggcggt agatttgcag gtgctgctgt tcgatgagtt cttgggcgca ttggacgctg 63420 aggttcgcta ggatctgcgg gtttggatcc agtgcctgca tgacgatgtg cacgtcacca 63480 cagtgcttgg ttcccaagga tcaggcctag gatcttgaca atgtcaagcc cagttatgtg 63540 gctaacggca gggctgggct ggcctcgggg atcgttatgg atcgctagga cgaagaattt 63600 gtcgtcgcct tgaacgactt taatgtctat gcagcccgct gatgaggatg ctaccgatga 63660 gaaggacggg tccagggttg aggaaaattt cctgcgacaa cttaagggag aacactggca 63720 ttatctgggg tttctccatc ggtgcgcgct ggttgggctc ccagtttgga tgcgctagct 63780 ttttcatcga cagctacagc ttttgctcga tgccccgttc gctctgggcc tccagagttt 63840 tggccatata ctggccgcag catggtccga cccctgccgt gactggcttg gtgtagcctg 63900 gcttaccggg cagtacccgg cttggtttac acccttttgc cggagtagcc cgacaaaatg 63960 tactgtcatc aggtggcttg gtctgtacat tactgcaagc atggcaggcc tgtaggtggt 64020 gaatgtcatg ctgatggtgg tcagtgtggc caggcaagtt gtatactgtt tctgccgagt 64080 acggcgcgta ataaccagcg acagtcgcta cgtccactct ccgcgtccaa ctcaagcggc 64140 tcaacaaaca agtaggccag tcttctgatg aggaagttca acacgaagcc gagcaccaaa 64200 aagccagcga tgttgttgat ttcgctaggc ttgtctttgg ctagttcttc gcatccgtgc 64260 cggccgatgg ccagcaaaag atacatggtg aagctctggt agatcacata tggaaattcg 64320 aagcttatcc ttctggatgg ggatcaaaaa cccgcattac attagaagaa cagcatggag 64380 tggcttgaac aggttgtggg tgaagttatc ccaaaattct tgaaacattt gagcggccct 64440 cttgtgtgtg cttgctacgg tgctcacgga agcatcgaat gttagccgga gctgacctag 64500 aacatctaag caaatgtcga cacttagact tgctcaggct aatccgcagc tcggtacacg 64560 cgcgggcttg tgaactggat tatggatgtg ccctgtaagc cctgatgcaa ggcggccgag 64620 acagtcaata agcatcgacg agacagtcta ttaggtatcg acaggaccac tattgggcgt 64680 tcgaaaccaa cgagggtgca cttcgacgca gcgtttacaa cgtatcacgg cttgccaccc 64740 cgatggcaac acggttcgcg cctaaacacg gtttagatcg gggcggtgtt cacggtcttt 64800 ttcgtcgccg tcgtcccacc tgcggctgga gcgttgaatc aactgtctag gtcggctgcg 64860 cacctactgt ctggccagcg cggtatcgtt ggttggccta ggcctcacgt tcatcccgac 64920 gacaccgact gtgatcgttg acctcgctgt gtcttgcact ggcgtgttct gttgagcaat 64980 cctgcgcgac cggatatccg gctgaggccg gtggtgcgga gcgatccagt cgggttgggt 65040 tgtatctgac gttctactac ttgtctatta cctgggtggg agcgttggaa ccatggcgct 65100 tgcgtcgctc taccggtatg tagtggtggt cagcctgcgt cggtttactc gccgtcgtgg 65160 tgcatcatca gcatggtcgt cgcgtgcgtc gcctggcgac tggagctgat acaccgagtg 65220 attgacctgg acgccgctgg cggtggcgca ggttgtctat gcggcagtat tcagtgccga 65280 catcgcttgc ccaacgtagg ttaaccaggc ctgctagcag aagatagaag atcctgagtt 65340 gctgcatagc ttcgacacag gttgcccggc gaagccgaac ctagctcgga ggtagcatgg 65400 tcgctcgaga tacgaaagac caggaacaag gtgtgcaccg gatgcatcat gtgcatcgtc 65460 catggaacac gtgaacggct tcatcagtct gtgaccgtcc gccacaatgc atcctaatcg 65520 aagagaaaga gatgaccatg aaatccatcg ccacctatgc agcgctggcc ataatcggag 65580 ccgccgtcga cggcctgaca tcgatggcta tcccgacggg cccggccgcg tcccacatac 65640 aacccgttgc cttcggtgtg ccgctgccgc aagatccggc accggctgcg gatgtgccga 65700 ccgcagccga attgaccagt ttgctcaata aaattgtcga tcctgatgtt tcgttcatgc 65760 acaagagcca gttggtcgag ggcggaatcg gttctgcgga ggctcatatt ggcgatcgcg 65820 agttgaaaaa tgcggctcag aagggtgaac tgccgttgtt gttcagtgtg acgaatattc 65880 gaccgggtac cagtggttca gccacggctg acgtttccgt gtcgggtccg aaactcaacc 65940 cgccggtcac gcagaacatc accttcatca ataagggcag ctgggtgctg tcgcgccact 66000 ccgcgatgga gctgttgcag gccgcggggc gttgagcacc gcggatcccg tcactgtctg 66060 cgctttaccg attcaaggct ctacaggttg agtttgttga tctgatgcgg atcggccagt 66120 acttcgatcg cggtgatccg tccgtcgcgt gtaatgaacc ccatgatcgt tgttgcttga 66180 ccggctacgt aaatgaccgt gcttacggtg cctttgacgg ttgcagtgcg cacttcgcgt 66240 tccggcagcg tgtagctgcg ggccagtttg gcgactgagg acacaccctg gacagcacgg 66300 gtctggcggc gccgggtacg acattaccgc gcagcactac gtcgggatgc agcaccgaca 66360 ccaatcgggc gaagtcgccg ctacgccagg ctgcgcagga acgcgtcgac tgcttcgcat 66420 tgcgcggcta tggttttcgt caggaaccgg aatcggtgtg ctagatgcgt cggtgcacaa 66480 ctgttcagct tgcaggttgt ctccggggtc cgatccccaa tgggatctgt tcgaactgta 66540 cggcgaagaa tgtcgtgcaa gacgaacgcc aaccgctccg ccggctgcaa cgtatacagc 66600 accaccaaca gcgccagccc caccgcattt gatcagctat ttgcccgatg ttcggtgtcg 66660 aattcaccca ctggatccac caccggatct gttatatgtg aggccagtcc tggtgatcgc 66720 gaccgacagt cgcagcgatc taggcaaatg cgggccacca cggtggtcag ccaagttcct 66780 agattgacga tggtcggcgc gtgggctcct cggtgctgct cagccgtagc cacgcttcct 66840 tcttcacggc gtcttgagcg taaatcgagc ccagcatgcg gtattcgagg gcgcccgact 66900 ggcggttagg gcttcgcgtc gaagcgcgcc gtcaagggag tttcggacgc atccacaata 66960 catgtgccgc cggcatccgg ctgctggctg gtgtagggga gcgcgcagac tcggccggtg 67020 gaaaagccga atgacccgat gctgtgaagt gggcacgcag gttgcccagc gtgatgatgt 67080 gggtcagtat caccagctgg gcggttttgc agtgggggcg tagcttatct aaaaattcgt 67140 agctcactcc gaccgggatg tagctaatcg cggtggtgta ttccaagatc ggtttgtcga 67200 cgtcggagaa gcgggaggcg tgctggtaat cggccatcgc cagcagttct tcgtcggtga 67260 tcctctattc gcggacgatc tgcgaactca agtcgatgca gaattcgcag tgaaccgttg 67320 tcgatgcctt ccggttaggc cagtgtgcgg tagcgcggat ggagaacacc cagtttcgat 67380 taggcctgcg ttagcctgct ttaggcattc aatagacttg atatatactg cgtataatct 67440 gcagcgattg tatcatgttg gcagtttcca gaccagccgt ctgcggccag cttccgctta 67500 gtgaagaaaa aggcgatttt ggcgcttagg ccggcgtcgt ggtcggcgac ttcgattggc 67560 cgggacatgg cgatcttcct gacatagggc taagactttg tcttcactta gtcgacacct 67620 ggtggccgcg aaacgtgacc ggtttaccca tgcgctcggg ccttaagtcc gtcttcccat 67680 cggcacgttc atgtcaaagc cccgcgcatg tagcaacgtg cgattgtgta gtgcggcgtg 67740 cactgcccaa tgtaggccat cctcgcgata aatgcctccc ctgccacctc accgtatgcg 67800 ggaaaggttg ccatagaacg tggaatcttc cgacagtaag aggtcgaacg cgaaaacggt 67860 cgtggtggta gccaaattcg tcgagcctaa aatctgctac aattggattt ttgtccagtt 67920 ccggtagcat agcccatgct cggggggggt atggtttgcc gtgtctggcg cctttgaaga 67980 tcatccatgc aactttgttg acgcgtcgct caagatcgac tgggtcatga gcccaggtta 68040 gccggaaaat cccgggccta ataggtcgca ccctggctgc acggagggct gccgacaatt 68100 ttgtctgttc caagacaaaa catcgatcat gaacttagcg ttcaggttgg tggggcaact 68160 ggctcaggcg catcgagtta ggtcgattta agataaccgc cgttgcgggt cggtggtcat 68220 cgctgacgac agtttcttta atcggctgat caagacgccg atctgtggtg gtgttgcaaa 68280 catgggtccg gtattctgta gcatcactga attcttccag cgggttcgca ggtgttggtg 68340 aattcttcgt gtagtgacag caggatgtcc atctgggttg tgtgagtgtg cagcggtacg 68400 gtgggtgatg tccagatatc ctaacgctca ctcggtggac ttgttgtttt gccaggtcat 68460 caagacttgg cttagcggat ggtgggccgg cgctggggtg ggcgtgagcc ataccaacaa 68520 cttttcggcg atccgagtca acgaacaagt tcagtctttg accttcatga tcatctagga 68580 ttgcccatcc aatctccaag gcccaccatg |