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EBI DbfetchID AL583918; SV 1; linear; genomic DNA; STD; PRO; 344050 BP. XX AC AL583918; XX DT 20-FEB-2001 (Rel. 66, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 3) XX DE Mycobacterium leprae strain TN complete genome; segment 2/10 XX KW . XX OS Mycobacterium leprae OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium. XX RN [1] RP 1-344050 RX DOI; 10.1038/35059006 RX PUBMED; 11234002. RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., RA Wheeler P.R., Honore N., Ganier T., Churcher C., Harris D., Mungall K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., RA Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., RA Jagels K., Lacroix C., Maclean J., Moule S., Murphy L., Oliver, Quail M.A., RA Rajandream M-A., Rutherford K.M., Rutter S., Seeger K., Simon S., RA Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., RA Whitehead S., Woodward J.R., Barrell B.G.; RT "Massive gene decay in the leprosy bacillus"; RL Nature 409(6823):1007-1011(2001). XX RN [2] RP 1-344050 RA Parkhill J.; RT ; RL Submitted (20-FEB-2001) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium leprae sequencing teams, The RL Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, RL UK Unitie de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du RL Docteur Rouux, 75724, Paris Cedex, France. E-mail: parkhill@sanger.ac.uk XX DR EMBL-CON; AL450380. DR RFAM; RF00059; TPP. XX CC Notes: CC CC Details of M. leprae sequencing at the Sanger Centre CC are available from http://www.sanger.ac.uk/Projects/M_leprae/ CC A relational datbase containing the M. leprae sequences is available from CC http://genolist.pasteur.fr/Leproma/ XX FH Key Location/Qualifiers FH FT source 1..344050 FT /organism="Mycobacterium leprae" FT /strain="TN" FT /mol_type="genomic DNA" FT /db_xref="taxon:1769" FT tRNA 340..413 FT /gene="leuX" FT /note="tRNA Leu anticodon TAA, Cove score 63.13" FT CDS complement(904..1275) FT /pseudo FT /transl_table=11 FT /gene="ML0264" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2775 (Best blastx score 95)" FT CDS 1708..1920 FT /transl_table=11 FT /gene="ML0265" FT /product="hypothetical protein" FT /note="Improbable CDS suggested by GC frameplot. Possibly FT the remains of a disrupted gene." FT /db_xref="UniProtKB/TrEMBL:O69587" FT /protein_id="CAC29773.1" FT /translation="MVLTVLVFALTESFTTSWIKQFSIAGILWVVLIGQLTGELFVRDF FT AAAERPDDVVKTQLFARIVTLLTWI" FT CDS 2709..3435 FT /pseudo FT /transl_table=11 FT /gene="ML0266" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1056 (Best blastx score 289)" FT repeat_region 4453..5480 FT /note="REPLEP region 2, 5'-end most similar to REPLEP 5 and FT 6; 3'-end most similar to REPLEP 11" FT repeat_region 4535..5414 FT /note="Dispersed repeat, REPLEP, copy 2" FT repeat_region 5415..5442 FT /note="28 bp subsequence of 45 bp REPLEP-associated FT sequence" FT CDS complement(6965..7892) FT /pseudo FT /transl_table=11 FT /gene="ackA" FT /gene_synonym="ML0267" FT /product="acetate kinase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT ackA (Best blastx score 257)" FT CDS complement(7893..8999) FT /pseudo FT /transl_table=11 FT /gene="pta" FT /gene_synonym="ML0268" FT /product="phosphate acetyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pta (Best blastx score 310)" FT CDS complement(9007..10017) FT /transl_table=11 FT /gene="ML0269" FT /product="putative F420-dependent glucose-6-phosphate FT dehydrogenase" FT /note="Similar to M. tuberculosis Rv0407, probable coenzyme FT F420-dependent enzyme, TR:P96253 (EMBL:AL123456) (336 aa); FT Fasta score E(): 0, 89.3% identity in 336 aa overlap. FT Similar to mycobacterial G6PDHs e.g. Mycobacterium avium FT fgd, F420-dependent glucose-6-phosphate dehydrogenase, FT TR:Q9XC15 (EMBL:AF152394) (336 aa); Fasta score E(): 0, FT 88.4% identity in 336 aa overlap. previously sequenced as FT TR:O69589 (EMBL:AL023514) (336 aa); Fasta score E(): 0, FT 100.0% identity in 336 aa overlap." FT /note="Shows weak similarity to ML0131" FT /db_xref="GOA:O69589" FT /db_xref="InterPro:IPR019945" FT /db_xref="UniProtKB/TrEMBL:O69589" FT /protein_id="CAC29777.1" FT /translation="MAELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWR FT HQGGHASFSLSWMTAVGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNRVFLG FT VGTGEALNEVATGYQGAWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKGASIY FT DVPEGGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKLIPAVLEGAAVAGRDA FT DDIDKMIEIKMSYDPDPEQALSNIRFWAPLSLAAEQKHSIDDPIEMEKVADALPIEQVA FT KRWIVVSDPDEAVARVGQYVTWGLNHLVFHAPGHNQRRFLELFEKDLAPRLRRLG" FT RBS complement(10030..10034) FT /note="possible RBS" FT CDS 10105..10860 FT /transl_table=11 FT /gene="ML0270" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0406c, hypothetical FT protein, TR:O86336 (EMBL:AL123456) (272 aa); Fasta score FT E(): 0, 74.9% identity in 243 aa overlap. Shows similarity FT to members of the metallo-beta-lactamase superfamily. FT Conserved in mycobacteria e.g. Mycobacterium avium bllP, FT beta-lactamase-like protein, TR:Q9XC16 (EMBL:AF152394) (247 FT aa); Fasta score E(): 0, 73.7% identity in 243 aa overlap. FT Previously sequenced as TR:O69590 (EMBL:AL023514) (251 aa); FT Fasta score E(): 0, 100.0% identity in 251 aa overlap. FT Contains Pfam match to entry PF00753 lactamase_B, FT Metallo-beta-lactamase superfamily." FT /db_xref="GOA:O69590" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/TrEMBL:O69590" FT /protein_id="CAC29778.1" FT /translation="MAAATLFQVTDSVHFARGDAVNWALVADDTGVMLIDTGYPGDRDD FT VVASLRQLGYEAGDVRAILLTHAHIDHMGSAIWFASKHRTPVYCHADEVGHTKREYLEQ FT VSLLNIAMRVWQPRWAIWSGHVLRSGGLIRGGIPTAQPLTAETAAGLPGHPMAIFTPGH FT TGGHCSYVVDGVLISGDALITGHPLLRHRGPQLLTAVFSHSQKQCLRSLDALGLLETRI FT LAPGHGELWHGPIREATEAALKQAGALTR" FT misc_feature 10150..10785 FT /note="Pfam match to entry PF00753 lactamase_B, FT Metallo-beta-lactamase superfamily, score 145.40, E-value FT 9.7e-40" FT CDS complement(10849..11220) FT /transl_table=11 FT /gene="ML0271" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv0401, putative membrane FT protein, TR:P95210 (EMBL:AL123456) (123 aa); Fasta score FT E(): 1.9e-32, 66.9% identity in 121 aa overlap. Similar to FT region of Arabidopsis thaliana F27F5.3, hypothetical FT protein, TR:AAF69175 (EMBL:AC007915) (261 aa); Fasta score FT E(): 1.5e-06, 30.8% identity in 120 aa overlap. Previously FT sequenced as TR:O69591 (EMBL:AL023514) (122 aa); Fasta FT score E(): 0, 100.0% identity in 122 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CCX5" FT /protein_id="CAC29779.1" FT /translation="MRLGQALAWLATDIVAVSVFCAVGRCSHAEGLTVADLAVTLWPFL FT TGTAIGWLASRGWQRPTAVVPTGVVVWLCTVVVGVALRKASSAGVVANFMVVAASTTAA FT LFLGWRAVVELILRRRSTR" FT CDS 11303..11922 FT /pseudo FT /transl_table=11 FT /gene="ML0272" FT /product="putative oxidoreductase (pseudogene)" FT /note="Possible oxidoreductase pseudogene. Similar to FT several M. tuberculosis genes e.g. Rv1941, Rv2214c, Rv2857c FT (Best blastx score 134)" FT CDS 11941..12489 FT /pseudo FT /transl_table=11 FT /gene="fadE7" FT /gene_synonym="ML0273" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE7 (Best blastx score 140)" FT CDS 12520..12618 FT /pseudo FT /transl_table=11 FT /gene="ML0274" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0398c (Best blastx score 86)" FT CDS complement(13557..14777) FT /transl_table=11 FT /gene="metZ" FT /gene_synonym="ML0275" FT /product="putative o-succinylhomoserine sulfhydrylase" FT /note="EC_number=4.2.99.-" FT /note="Similar to M. tuberculosis metZ, Rv0391, FT o-succinylhomoserine sulfhydrylase, TR:P95199 FT (EMBL:AL123456) (406 aa); Fasta score E(): 0, 87.9% FT identity in 406 aa overlap. Similar to many e.g. FT Pseudomonas aeruginosa metZ, o-succinylhomoserine FT sulfhydrylase, SW:METZ_PSEAE (P55218) (403 aa); Fasta score FT E(): 0, 44.3% identity in 406 aa overlap. Previously FT sequenced as TR:O69592 (EMBL:AL023514) (426 aa); Fasta FT score E(): 0, 100.0% identity in 406 aa overlap. Contains FT Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met FT metabolism PLP-dependent enzyme." FT /note="Similar to ML2394" FT /db_xref="GOA:Q9CCX4" FT /db_xref="HSSP:1GC0" FT /db_xref="InterPro:IPR015422" FT /db_xref="UniProtKB/TrEMBL:Q9CCX4" FT /protein_id="CAC29783.1" FT /translation="MTDDRSVRTPKALPDGVTAATVGVRGGLLRSRFEETAETMYLTSG FT YVYESAVVAEKSFTGELDHFVYSRYGNPTVTMFEERLRLIEGAPAAFVTASGMAAVFTS FT LGALLASGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLVQWEQALSVPTQAVF FT FETPSNPMQSLVDIAAVTELAHAAGAKVVLDNAFATPLLQHGLPLGVDVVIYSGTKHID FT GQGRVLGGAILGDRDYIDGPVQKLMRHTGPAMSAFNAWILLKGLETLAIRVDHCNSSAH FT RIAEFLEKHPAVSWVRYPFLVSHPQYDLAKRQMSGGGTVVTFALNSPEDAAKQRAFEVL FT DRLRLIDISNNFGDVKSLITHPATTTHRAMGPEGRAAIGLGDGVVRISIGLEDAADLIA FT DIDQALS" FT misc_feature complement(13560..14720) FT /note="Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met FT metabolism PLP-dependent enzyme, score 638.40, E-value FT 3.8e-188" FT RBS complement(14789..14792) FT /note="possible RBS" FT CDS complement(14834..15277) FT /transl_table=11 FT /gene="ML0276" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0390, hypothetical FT protein, TR:P95198 (AL123456) (140 aa); Fasta score E(): 0, FT 79.0% identity in 138 aa overlap. Also similar to FT Rickettsia prowazekii RP600, hypothetical protein, FT TR:Q9ZCV8 (EMBL:AJ235272) (123 aa); Fasta score E(): FT 8.6e-05, 35.1% identity in 134 aa overlap. Previously FT sequenced as TR:O69593 (EMBL:AL023514) (147 aa); Fasta FT score E(): 0, 100.0% identity in 147 aa overlap." FT /db_xref="InterPro:IPR001763" FT /db_xref="UniProtKB/TrEMBL:O69593" FT /protein_id="CAC29784.1" FT /translation="MSTEMNRPYAGDITPLQAWKMLSDNPHTVLVDVRTDAEWRFVGVP FT DTSSLGREVVYIEWNTSDGLPNVNFLAELQERIPPANAERGERPVVFLCRSGHRSMGAA FT QVATDAGISPSYNILDGFEGHLNAEGHRGETGWRAVGLPWKQL" FT CDS 16202..16638 FT /pseudo FT /transl_table=11 FT /gene="ML0277" FT /product="PPE-family protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT PPE-family proteins (Best blastx score 74)" FT CDS 16751..17125 FT /pseudo FT /transl_table=11 FT /gene="ML0278" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv0387c (Best blastx score 97)" FT CDS complement(17297..17953) FT /transl_table=11 FT /gene="ML0279" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0356c, hypothetical FT protein, TR:O06307 (EMBL:AL123456) (214 aa); Fasta score FT E(): 0, 73.4% identity in 214 aa overlap. Previously FT sequenced as TR:O69594 (EMBL:AL023514) (218 aa); Fasta FT score E(): 0, 99.5% identity in 218 aa overlap." FT /db_xref="InterPro:IPR018062" FT /db_xref="UniProtKB/TrEMBL:O69594" FT /protein_id="CAC29787.1" FT /translation="MTYYSSLRPEDLPPERPKHEHYSGFPEYELANPGVGFRRFVATMR FT RLQDLAVSADPSDEVWYAAADRAVALVELLGPFATDEGKAPAGRVPDMPGMGSLLLPPW FT TLTRSGPDSVEMTGYFTRFHVGFNHAVHGGVLPLVFDHLFGMISYTAGRSISRTAFLHV FT DYRKITPIDEPLVMRGRVTRTEGRKAFVSAELVDGDEMLLAEGNGMMVRLLAGQP" FT CDS complement(17950..19248) FT /transl_table=11 FT /gene="purA" FT /gene_synonym="ML0280" FT /product="putative adenylosuccinate synthase" FT /EC_number="6.3.4.4" FT /note="Similar to M. tuberculosis purA, Rv0357c, FT adenylosuccinate synthase, SW:PURA_MYCTU (O08381) (432 aa); FT Fasta score E(): 0, 87.9% identity in 431 aa overlap. FT Similar to many e.g. Escherichia coli purA, FT adenylosuccinate synthase, SW:PURA_ECOLI (P12283) (431 aa); FT Fasta score E(): 0, 51.1% identity in 425 aa overlap. FT Previously sequenced as SW:PURA_MYCLE (O69595) (432 aa); FT Fasta score E(): 0, 100.0% identity in 432 aa overlap. FT Contains Pfam match to entry PF00709 Adenylsucc_synt, FT Adenylosuccinate synthetase. Contains PS00513 FT Adenylosuccinate synthetase active site. Contains PS01266 FT Adenylosuccinate synthetase GTP-binding site." FT /db_xref="GOA:O69595" FT /db_xref="HSSP:1ADE" FT /db_xref="InterPro:IPR001114" FT /db_xref="UniProtKB/Swiss-Prot:O69595" FT /protein_id="CAC29788.1" FT /translation="MPAVVLIGAQWGDEGKGKVTDLLGGRAQWVVRYQGGNNAGHTVVL FT PTGENFTLHLIPSGVLTPGVTNVIGNGVVVDPGVLLSELQGLEDRGVDTSQLLISADAH FT LLMPYHVAIDKVTERYMGNKKIGTTGRGIGPCYQDKIARMGIRVADVLEPGELTHKIEA FT ALEFKNQVLVKIYNRKALDLAQVVETLLEQAQQFRHRITDTRLLLNDALEAGETVLLEG FT AQGTLLDVDHGTYPYVTSSNPTAGGAALGSGIGPTRIHTVLGILKAYTTRVGSGPFPTE FT LFDENGEYLAKTGSEIGVTTGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLET FT VPVCVGYQIAGVRTHDMPITQSDLARAEPIYEELPGWWEDISGAREFEDLPAKARDYVL FT RLEELAGAQVACIGVGPGRDQTIVRCDVLRSRR" FT RBS complement(17960..17964) FT /note="possible RBS" FT misc_feature complement(18070..19236) FT /note="Pfam match to entry PF00709 Adenylsucc_synt, FT Adenylosuccinate synthetase, score 729.00, E-value FT 2.1e-215" FT misc_feature complement(18820..18855) FT /note="PS00513 Adenylosuccinate synthetase active site" FT misc_feature complement(19198..19221) FT /note="PS01266 Adenylosuccinate synthetase GTP-binding FT site" FT RBS 19423..19427 FT /note="possible RBS" FT CDS 19432..20121 FT /transl_table=11 FT /gene="ML0281" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0358, hypothetical FT protein, TR:O06308 (EMBL:AL123456) (215 aa); Fasta score FT E(): 0, 62.4% identity in 229 aa overlap. Previously FT sequenced as TR:O69596 (EMBL:AL023514) (229 aa); Fasta FT score E(): 0, 99.6% identity in 229 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O69596" FT /protein_id="CAC29789.1" FT /translation="MNTSDSAPGVAVLLFGDDRTRQRWNTLTALSTYRAGGPDDIDSID FT ATIGPYRRLVVVGGDGDLAAVLGRLLRADRLDIEVAYVPHQRTAATRVYRLPTGRRAAR FT RARRGYATRVPLIRDETGSVIVGRADWLPVVDRQPLHGEAIVDDIPLFDGDVAGVRIAP FT TLAMPGLRARLHTSRTGIGIWSRWLTGRAVQLGSTGVAVVRDGVPTRRRERRSTFYRNV FT EGWMLVR" FT CDS 20131..20909 FT /pseudo FT /transl_table=11 FT /gene="ML0282" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0359 (Best blastx score 161)" FT CDS 20916..21722 FT /transl_table=11 FT /gene="ML0283" FT /product="putative cation-efflux transporter component" FT /note="Similar to many cation-efflux transporter components FT e.g. Alcaligenes eutrophus czcD, cobalt-zinc-cadmium FT resistance protein, SW:CZCD_ALCEU (P13512) (316 aa); Fasta FT score E(): 3.8e-22, 36.4% identity in 209 aa overlap. FT Previously sequenced as TR:O69597 (EMBL:AL023514) (256 aa); FT Fasta score E(): 0, 100.0% identity in 256 aa overlap. FT Contains hydrophobic, possible membrane-spanning regions. FT Beyond codon 220 (approx.) GC frameplot and codon useage FT plots indicate a possible frame change. Similarity to FT characterised transporter components ends at this point. FT This suggests that the ORF may have suffered a disruption FT and therefore not encode a functional product. Contains FT Pfam match to entry PF01545 Cation_efflux, Cation efflux FT family." FT /db_xref="GOA:Q9CCX3" FT /db_xref="InterPro:IPR002524" FT /db_xref="UniProtKB/TrEMBL:Q9CCX3" FT /protein_id="CAC29791.1" FT /translation="MQCMRKHAYIAHMGSGGSYTPAEAAIYRMIRRMIVAAAILMVFFG FT VELTIALLINSITLLADAGHMLTDVVAVFMGLAALVLAKHGHSAPNRPYSWHRAEVFTA FT MANAALLIGVATFILYEAIRRFKEAPYIPGMPIVVAALAGLVTNFVVALLLRPHAEDSL FT AIKGAYMEAVADTVGNIGVLIAGVVTLTTHWPYADVVVAVLVALWVLPRAISLARAACG FT SFPNCRRPTIDVEALRSALGRRRRHRSARPARVNTFARRRYVPPRT" FT misc_feature 21174..21719 FT /note="Pfam match to entry PF01545 Cation_efflux, Cation FT efflux family, score 17.10, E-value 0.0001" FT CDS complement(21860..22273) FT /transl_table=11 FT /gene="ML0284" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0360c, hypothetical FT protein, TR:O06310 (EMBL:AL123456) (145 aa); Fasta score FT E(): 0, 85.4% identity in 137 aa overlap and Streptomyces FT coelicolor SCH10.25C, hypothetical protein, TR:Q9X8R4 FT (EMBL:AL049754) (143 aa); Fasta score E(): 8.2e-27, 56.2% FT identity in 130 aa overlap. Previously sequenced as FT TR:O69598 (EMBL:AL023514) (137 aa); Fasta score E(): 0, FT 100.0% identity in 137 aa overlap." FT /db_xref="InterPro:IPR014487" FT /db_xref="UniProtKB/TrEMBL:O69598" FT /protein_id="CAC29792.1" FT /translation="MTSMGDLLGPDPILLPDDSAAEVELRANKDPGTVAAAHPSASVAW FT AALAEGALADDKATTAYAYARTGYHRGLDQLRCNGWKGFGPVPYSHEPNRGFLRCVAAL FT ARAANAIGETDEYRRCLNLLDDCDPAARNELGL" FT RBS complement(22277..22283) FT /note="possible RBS" FT RBS 22374..22378 FT /note="possible RBS" FT CDS 22385..23263 FT /transl_table=11 FT /gene="ML0285" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv0361, possible membrane FT protein, TR:O06311 (EMBL:AL123456) (275 aa); Fasta score FT E(): 0, 58.6% identity in 292 aa overlap. Previously FT sequenced as TR:O69599 (EMBL:AL023514) (292 aa); Fasta FT score E(): 0, 100.0% identity in 292 aa overlap. Contains FT hydrophobic, possible membrane-spanning region." FT /db_xref="UniProtKB/TrEMBL:O69599" FT /protein_id="CAC29793.1" FT /translation="MPNASEPERGITLNRPGLAPRTLDKNVVSNLPEAKDNPAMTHGEE FT IAAGYPLAHSDSETEAMVLTKTEPDQDPGADRQHHERRFTAPGFDARATAIMATAPDPA FT TEAIHPPLSSSDPPGHLGISPKAAVPQSIPPVLGTKLRSARHFHWGWVVALLMMVLALA FT AIAILGTVLLTRGKHVKASPAEQVRHAIQSFDVAVQTGNLTALRSITCGTTRDGYVEYD FT ESSWDETYHRVSAAKQYPVIASIDQVVVNGQHAEANITTFMAYDPQVRSTRSLDLQFCD FT DQWKICQSPSG" FT CDS complement(23279..24316) FT /transl_table=11 FT /gene="fba" FT /gene_synonym="ML0286" FT /product="putative fructose bisphosphate aldolase" FT /EC_number="4.1.2.13" FT /note="Similar to M. tuberculosis fba, Rv0363c, fructose FT bisphosphate aldolase, SW:ALF_MYCTU (O06313) (344 aa); FT Fasta score E(): 0, 87.7% identity in 342 aa overlap. FT Similar to many e.g. Corynebacterium glutamicum, fructose FT bisphosphate aldolase, SW:ALF_CORGL (P19537) (343 aa); FT Fasta score E(): 0, 72.8% identity in 342 aa overlap. FT Previously sequenced as SW:ALF_MYCLE (O69600) (345 aa); FT Fasta score E(): 0, 100.0% identity in 345 aa overlap. FT Contains Pfam match to entry PF01116 F_bP_aldolase, FT Fructose-bisphosphate aldolase class-II. Contains PS00806 FT Fructose-bisphosphate aldolase class-II signature 2. FT Contains PS00602 Fructose-bisphosphate aldolase class-II FT signature 1." FT /db_xref="GOA:O69600" FT /db_xref="HSSP:1B57" FT /db_xref="InterPro:IPR000771" FT /db_xref="UniProtKB/Swiss-Prot:O69600" FT /protein_id="CAC29794.1" FT /translation="MPIATPEIYAEMLRRAKENSYAFPAINCTSSETVNAAIKGFADAG FT SDGIIQFSTGGAEFASGLGVKDMVTGAVALAKFTHTIAAKYPINVALHTDHCPKDKLDS FT YVRPLLAISARRVATGKDPLFGSHMWDGSAIPIDENLAIAQDLLKDAAAAKIILEVEIG FT VVGGEEDGVAGEINEKLYTTPKDFVKTIDALGAGEHGKYLLAATFGNVHGVYKPGNVKL FT RPDILAEGQKVAAAKLSQSEGSKPFDFVFHGGSGSEKSEIEEALRYGVVKMNVDTDTQY FT AFTRPVSGHMFTNYDGVLKVDGDVGNKKVYDPRSYLKKAEASMTERVLEACNDLRCAGK FT SVAAS" FT misc_feature complement(23294..24304) FT /note="Pfam match to entry PF01116 F_bP_aldolase, FT Fructose-bisphosphate aldolase class-II, score 484.30, FT E-value 9.4e-142" FT misc_feature complement(23810..23845) FT /note="PS00806 Fructose-bisphosphate aldolase class-II FT signature 2" FT misc_feature complement(24026..24061) FT /note="PS00602 Fructose-bisphosphate aldolase class-II FT signature 1" FT RBS complement(24324..24330) FT /note="possible RBS" FT CDS 24449..25117 FT /transl_table=11 FT /gene="ML0287" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv0364, hypothetical FT protein, SW:Y364_MYCTU (O06314) (227 aa); Fasta score E(): FT 0, 66.1% identity in 227 aa overlap. Similar to many FT dedA-family proteins e.g. Streptomyces coelicolor SCE9.18C, FT possible membrane protein, TR:Q9X8J1 (EMBL:AL049841) (303 FT aa); Fasta score E(): 0, 42.8% identity in 201 aa overlap. FT Previously sequenced as TR:O69601 (EMBL:AL023514) (222 aa); FT Fasta score E(): 0, 100.0% identity in 222 aa overlap. FT Contains hydrophobic, possible membrane-spanning regions. FT Contains Pfam match to entry PF00597 DedA, DedA family." FT /db_xref="GOA:O69601" FT /db_xref="InterPro:IPR015414" FT /db_xref="UniProtKB/Swiss-Prot:O69601" FT /protein_id="CAC29795.1" FT /translation="MNTAIVALPPTLDPMFWIGPEGFFAAAMLPATLVIIFVETGLLFP FT LLPGESLLFTGGLLATKGTIDIWVLSPSVAVVAVLGDQIGYLIGRRIGPALFKKENSRF FT FKQHYVTESHAFFEKHGRWTIILARFLPFMRTFTPVIAGLSYMSYPLYLGFDIVGGILW FT GGGVTVAGYFLGNVPFVRQNLEKIILGILFVSLLPALIAAWHGYRSQSRTAKSELALPD FT " FT misc_feature 24536..25018 FT /note="Pfam match to entry PF00597 DedA, DedA family, score FT 99.60, E-value 6e-26" FT repeat_region 25095..25127 FT /note="33 bp sequence found at 5'-end of copies 2 and 7 of FT LEPREP " FT repeat_region 25128..27510 FT /note="Dispersed repeat, LEPREP, copy 2 " FT CDS 25473..25612 FT /pseudo FT /transl_table=11 FT /gene="ML0288" FT /note="Similar to Pseudomonas putida transposase tnpa1 FT TR:Q9R9U9 (EMBL:AJ245436) (355 aa) fasta scores: E(): FT 3.4e-05, 47.8% id in 46 aa, and to Agrobacterium FT tumefaciens transposase TR:Q44454 (EMBL:Z18270) (366 aa) FT fasta scores: E(): 0.00026, 41.3% id in 46 aa" FT CDS 25817..26960 FT /pseudo FT /transl_table=11 FT /gene="ML0289" FT /product="putative group II intron maturase-related FT protein" FT /note="Similar to many e.g. Cryphonectria parasitica FT (Chesnut blight fungus) putative maturase TR:AAF27656 FT (EMBL:AF218567) (778 aa) fasta scores: E(): 7.8e-11, 29.2% FT id in 216 aa" FT stem_loop 26444..26497 FT CDS 27225..27323 FT /pseudo FT /transl_table=11 FT /gene="ML0290" FT /note="Similar to Agrobacterium tumefaciens transposase FT TR:Q44454 (EMBL:Z18270) (366 aa) fasta scores: E(): 0.0002, FT 51.5% id in 33 aa, and to Pseudomonas putida transposase FT tnpa1 TR:Q9R9U9 (EMBL:AJ245436) (355 aa) fasta scores: E(): FT 0.00088, 48.5% id in 33 aa" FT repeat_region 27511..27531 FT /note="21 bp sequence found at 3'-ends of copies 2, 3, 4 FT and 6 of LEPREP" FT CDS complement(28034..28426) FT /transl_table=11 FT /gene="ML0291" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O69603 FT (EMBL:AL023514) (130 aa); Fasta score E(): 0, 99.2% FT identity in 130 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O69603" FT /protein_id="CAC29799.1" FT /translation="MEVARIVSPVNAHSSSSVATDPNEVFHQPDQLSFVGEVRWLAEVA FT IRTNPLRSFLPFSTNSMMRSLPAHRTTETKNLSHADKIRNRIGLVFARATPTFQPTKTT FT DRTKRSPRSNTTYVMLDSGVDTPDVA" FT CDS complement(29605..29844) FT /transl_table=11 FT /gene="ML0292" FT /product="hypothetical protein" FT /note="Unknown function. Possibly the remains of a FT disrupted gene." FT /db_xref="UniProtKB/TrEMBL:Q9CCX2" FT /protein_id="CAC29800.1" FT /translation="MPAYGTASGRRILEAILIASDIDIIVYHLLTSKVHQYHIAYHEFG FT NVLAGNHQVVSENYALHLLASSIDPIPRAKYPGP" FT RBS complement(29854..29857) FT /note="possible RBS" FT CDS complement(31453..31662) FT /transl_table=11 FT /gene="ML0293" FT /product="hypothetical protein" FT /note="Unknown function. Possibly the remains of a FT disrupted gene." FT /db_xref="UniProtKB/TrEMBL:Q9CCX1" FT /protein_id="CAC29801.1" FT /translation="MPVAYFFDDDPSKQIQTELELLGAVCNMGVSNIALYAANHRQTSS FT GTVSDIIDKLVKREALERTDGRHG" FT RBS 33474..33479 FT /note="possible RBS" FT CDS 33487..35130 FT /transl_table=11 FT /gene="thiC" FT /gene_synonym="ML0294" FT /product="putative thiamine biosynthesis protein" FT /note="Similar to M. tuberculosis thiC, Rv0423c, thiamine FT biosynthesis protein, SW:THIC_MYCTU (P96269) (547 aa); FT Fasta score E(): 0, 90.1% identity in 547 aa overlap. FT Similar to many e.g. Escherichia coli thiC, thiamine FT biosynthesis protein, SW:THIC_ECOLI (P30136) (631 aa); FT Fasta score E(): 0, 59.2% identity in 593 aa overlap. FT Previously sequenced as SW:THIC_MYCLE (Q9ZBL0) (547 aa); FT Fasta score E(): 0, 100.0% identity in 547 aa overlap. FT Contains Pfam match to entry PF01964 ThiC, ThiC family." FT /db_xref="GOA:Q9ZBL0" FT /db_xref="InterPro:IPR002817" FT /db_xref="UniProtKB/Swiss-Prot:Q9ZBL0" FT /protein_id="CAC29802.1" FT /translation="MTETLSKTTEPSVTTGPIPGSSKAYREVANPDGGPSLRVPFRRVH FT LSTGAHFDLYDTSGPYTDPDAVINLTAGLPPRPGVIRDRGTQLQRARAGEITAEMAFIA FT DREGMPAELVRVEVALGRAVIPANHNHPEIEPMIIGKAFAVKVNANIGNSAVTSSIAEE FT IDKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTKLT FT WEIYRDTVIEQCEQGVDYMTVHAGVLLRYVLLTAKRVTGIVSRGGSIMASWCLANHRES FT FLYTNFAELCDIFARYDVTFSLGDGLRPGSIADANDTAQFAELRTLGELSKIAKVHGAQ FT VMIEGPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAVIAQA FT GTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGYPRAQERDDALSTARFEF FT RWNDQFALSLDPPTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRITADIRVYAAKHGL FT DTEEAIEMGMTEKSAEFAEHGNRVYLPLTQ" FT misc_feature 33742..35013 FT /note="Pfam match to entry PF01964 ThiC, ThiC family, score FT 1105.40, E-value 0" FT CDS 35127..35966 FT /transl_table=11 FT /gene="thiD" FT /gene_synonym="ML0295" FT /product="putative phosphomethylpyrimidine kinase" FT /EC_number="2.7.4.7" FT /note="Similar to M. tuberculosis thiD, Rv0422c, FT phosphomethylpyrimidine kinase, SW:THID_MYCTU (P96268) (265 FT aa); Fasta score E(): 0, 77.8% identity in 266 aa overlap. FT Similar to many e.g. Escherichia coli thiD, FT phosphomethylpyrimidine kinase, SW:THID_ECOLI (P76422) (266 FT aa); Fasta score E(): 3.2e-29, 38.4% identity in 263 aa FT overlap. Previously sequenced as SW:THID_MYCLE (Q9ZBL1) FT (279 aa); Fasta score E(): 0, 99.6% identity in 279 aa FT overlap." FT /db_xref="GOA:Q9ZBL1" FT /db_xref="HSSP:1JXH" FT /db_xref="InterPro:IPR004399" FT /db_xref="UniProtKB/Swiss-Prot:Q9ZBL1" FT /protein_id="CAC29803.1" FT /translation="MNYLPAPPPGTTPLRVLSIAGSDSGGGAGIQADMRTMTVLGVHAC FT TAVTAVTIQNTLGVEGFHEIPAEIVASQIKAVVTDIGIQSAKTGMLASSSIIAAVAETW FT LRLELTTPLVVDPVCASMHGDPLLTGEAMDSLRDRLFPLATVVTPNLDEVRLLVGIDVV FT DTESQRAAAMALHALGPQWALVKGGHLRSSDRSCDLLYGGSSAGVAFHEFDAPRVQTGN FT DHGGGDTLAAAVSCALAHGYTVPDAVGFGKRWVTECLRDAYPLGRGHGPVSPLFQRT" FT CDS 36011..36147 FT /pseudo FT /transl_table=11 FT /gene="ML0296" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0421c (Best blastx score 85)" FT CDS complement(36645..37430) FT /transl_table=11 FT /gene="thiG" FT /gene_synonym="ML0297" FT /product="putative thiamine biosynthesis protein" FT /note="Similar to M. tuberculosis Rv0417, hypothetical FT protein, TR:P96263 (EMBL:AL123456) (252 aa); Fasta score FT E(): 0, 86.8% identity in 250 aa overlap. Similar to many FT proteins involved in the biosynthesis of the thiazole FT moiety of thiamine e.g. Escherichia coli thiG, thiamine FT biosynthetic protein (thiazole moiety), SW:THIG_ECOLI FT (P30139) (281 aa); Fasta score E(): 0, 51.2% identity in FT 244 aa overlap. Previously sequenced as TR:Q9ZBL2 FT (EMBL:AL035159) (261 aa); Fasta score E(): 0, 99.6% FT identity in 261 aa overlap." FT /db_xref="GOA:Q9ZBL2" FT /db_xref="InterPro:IPR008867" FT /db_xref="UniProtKB/Swiss-Prot:Q9ZBL2" FT /protein_id="CAC29805.1" FT /translation="MVESKFTIGDRTFTSRLIMGTGGAANLAILEEALIASGTELTTVA FT IRRVDTDGGSGLLKLLSRLDIMPLPNTAGCRSAAEAVLTAQLAREALNTNWIKLEVIAD FT ERTLLPDGLELVRAAEQLVDAGFVVLPYTNDDPALAHRLEGTGCAAVMPLGSPIGTGLG FT INNPHNIEIIVAQARVPVVLDAGIGTTSDAALAMELGCDAVLLASAVTRAVDPPTMAAA FT MASAVTAGYLARRAGRIPKRFWAQASSPELMRTGEELGN" FT CDS complement(37423..37647) FT /transl_table=11 FT /gene="ML0298" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0416, conserved FT hypothetical protein, TR:P96262 (EMBL:AL123456) (68 aa); FT Fasta score E(): 5.9e-17, 71.6% identity in 74 aa overlap. FT Similar to bacterial hypothetical protein e.g. Escherichia FT coli thiS, hypothetical protein, SW:THIS_ECOLI (O32583) (66 FT aa); Fasta score E(): 0.41, 32.0% identity in 50 aa FT overlap. Previously sequenced as TR:Q9ZBL3 (EMBL:AL035159) FT (74 aa); Fasta score E(): 1.2e-28, 100.0% identity in 74 aa FT overlap." FT /db_xref="InterPro:IPR012675" FT /db_xref="UniProtKB/TrEMBL:Q9ZBL3" FT /protein_id="CAC29806.1" FT /translation="MIVVVNERPVEVNEQTTVAALLESLGFPASGIAVAVEFSVLPRSY FT WATKISELPAVTGRSEPIRLEVVTAVQGG" FT CDS complement(37655..38677) FT /transl_table=11 FT /gene="ML0299" FT /product="putative oxidoreductase" FT /note="Similar to M. tuberculosis Rv0415, conserved FT hypothetical protein, TR:P96261 (EMBL:AL123456) (340 aa); FT Fasta score E(): 0, 82.0% identity in 338 aa overlap. Shows FT weak similarity to Bacillus subtilis goxB, glycine oxidase, FT SW:GLOX_BACSU (O31616) (369 aa); Fasta score E(): 6.6e-10, FT 28.7% identity in 352 aa overlap. Previously sequenced as FT TR:Q9ZBL4 (EMBL:AL035159) (340 aa); Fasta score E(): 0, FT 100.0% identity in 340 aa overlap. Contains Pfam match to FT entry PF01266 DAO, D-amino acid oxidase." FT /note="Shows weak similarity to ML2011" FT /db_xref="GOA:Q9ZBL4" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9ZBL4" FT /protein_id="CAC29807.1" FT /translation="MPSGPPAGSLAVIGGGVIGLSVARRAVQAGWSVRVHRTHEQGASW FT VAGGMLAPHSEGRPGEEQLLQLGLRSLRLWHEGGFTDRLAPEVITARESLVVAVDQADV FT ADLRTVADWLSTQGHPVIWESAARDIEPLLAQGIRHGFWAPNELAVDNRALLAGLCLDC FT ERLGVRWASPVNDLSCVNADAVVIANGIGAPALWPGLPVRPVKGEVLRLRWRNGCMSLL FT KRLIRAHVHGRQVYLVPRADGVVVGATQYEHGYDTAPVVSGVRDLLDDACAVLPTLGEY FT ELAECAAGLRPTTPNNLPLVHRLDNRTLVAAGHGRSGFLLAPWTAEQIMFELAAVGAQA FT " FT misc_feature complement(37664..38656) FT /note="Pfam match to entry PF01266 DAO, D-amino acid FT oxidase, score 35.40, E-value 3.5e-09" FT RBS complement(38683..38688) FT /note="possible RBS" FT CDS 38835..39542 FT /transl_table=11 FT /gene="thiE" FT /gene_synonym="ML0300" FT /product="putative thiamine-phosphate pyrophosphorylase" FT /EC_number="2.5.1.3" FT /note="Similar to M. tuberculosis thiE, Rv0414c, putative FT thiamine-phosphate pyrophosphorylase, SW:THIE_MYCTU FT (P96260) (222 aa); Fasta score E(): 0, 78.9% identity in FT 223 aa overlap. Similar to many e.g. Escherichia coli thiE, FT thiamine-phosphate pyrophosphorylase, SW:THIE_ECOLI FT (P30137) (211 aa); Fasta score E(): 5e-10, 38.7% identity FT in 199 aa overlap. Previously sequenced as SW:THIE_MYCLE FT (Q9ZBL5) (235 aa); Fasta score E(): 0, 99.6% identity in FT 235 aa overlap." FT /db_xref="GOA:Q9ZBL5" FT /db_xref="InterPro:IPR003733" FT /db_xref="UniProtKB/Swiss-Prot:Q9ZBL5" FT /protein_id="CAC29808.1" FT /translation="MQEPHRQPAICLSTRLAKARLYLCTDARRERGDLAQFVNAALAGG FT VDIVQLRDKGSVGEQQFGPLEARDALAACEIFTDATGRHDALFAVNDRADIARAAGADV FT LHLGQGDLPPGVARQIVCRQMLIGLSTHDRHQVAAAVAALDAGLVDYFCVGPCWPTPTK FT PDRPAPGLELVRAAAELAGDKPWFAIGGIDAQRLPDVLHAGARRIVVVRAITAAADPRA FT AAEQLISTLTATS" FT CDS complement(39529..40154) FT /pseudo FT /transl_table=11 FT /gene="mutT3" FT /gene_synonym="ML0301" FT /product="MutT homologue (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT mutT3 (Best blastx score 180)" FT CDS 40334..41649 FT /pseudo FT /transl_table=11 FT /gene="ML0302" FT /product="putative membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0412c (Best blastx score 1672)" FT RBS 41638..41642 FT /note="possible RBS" FT CDS 41649..42629 FT /transl_table=11 FT /gene="glnH" FT /gene_synonym="ML0303" FT /product="putative glutamine-binding protein" FT /note="Similar to M. tuberculosis glnH, Rv0411c, putative FT glutamine-binding protein, TR:P96257 (EMBL:AL123456) (328 FT aa); Fasta score E(): 0, 79.3% identity in 328 aa overlap. FT Similar to many bacterial solute-binding proteins e.g. FT Bacillus stearothermophilus glnH, glutamine-binding FT protein, SW:GLNH_BACST (P27676) (262 aa); Fasta score E(): FT 3.7e-23, 38.1% identity in 194 aa overlap. Previously FT sequenced as TR:Q9ZBL7 (EMBL:AL035159) (325 aa); Fasta FT score E(): 0, 100.0% identity in 325 aa overlap. Contains a FT probable N-terminal signal sequence. Contains Pfam match to FT entry PF00497 SBP_bac_3, Bacterial extracellular FT solute-binding proteins, family 3. Contains PS01039 FT Bacterial extracellular solute-binding proteins, family 3 FT signature. Contains PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="GOA:Q9CCX0" FT /db_xref="InterPro:IPR001638" FT /db_xref="UniProtKB/TrEMBL:Q9CCX0" FT /protein_id="CAC29811.1" FT /translation="MMTRQFKIQRACSVLATAMMLAACGHAELLTVASMPTLPPPTPVG FT MEQVPPELLLPQDNTEEDCDPTASLRPFPTKAEADAAVAEIRARGRLIVGLEIGSNLFS FT FRDPITGEITGFDIDIAGEVARDIFGTPSHMEYRILSTAARITALQKSEVDIIVKTMTI FT TCKRRKLVNFSTVYLDAKQRILAPRDSPITKPSDLSNKRVCMTRGTTSLHQVSEVVPPP FT IIVSAENWADCLVAMQQREIDAISTDDAILAGLVEEDPYLHIVGPNMATQPYGIGINLN FT NTTLVRFVNGTLERIRRDGTWITLYRKWLTVLGPAPAPPTPRYVD" FT misc_feature 41670..42578 FT /note="Pfam match to entry PF00497 SBP_bac_3, Bacterial FT extracellular solute-binding proteins, family 3, score FT 98.70, E-value 1.2e-25" FT misc_feature 41688..41720 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT misc_feature 41991..42032 FT /note="PS01039 Bacterial extracellular solute-binding FT proteins, family 3 signature" FT CDS 42629..44932 FT /transl_table=11 FT /gene="pknG" FT /gene_synonym="ML0304" FT /product="putative serine-threonine protein kinase" FT /note="Similar to M. tuberculosis pknG, Rv0410c, putative FT serine/threonine protein kinase, TR:P96256 (EMBL:AL123456) FT (750 aa); Fasta score E(): 0, 83.1% identity in 756 aa FT overlap. Similar to many bacterial putative FT serine/threonine protein kinases e.g. Streptomyces FT coelicolor SC6D10.09, possible protein kinase, TR:CAB71204 FT (EMBL:AL138538) (903 aa); Fasta score E(): 0, 42.0% FT identity in 793 aa overlap. Similar in part, to protein FT kinases from Myxococcus xanthus e.g. pkn12, FT serine/threonine protein kinase, TR:Q9XBP5 (EMBL:AF159692) FT (465 aa); Fasta score E(): 2.9e-10, 28.4% identity in 292 FT aa overlap. Previously sequenced as TR:Q9ZBL8 FT (EMBL:AL035159) (763 aa); Fasta score E(): 0, 100.0% FT identity in 763 aa overlap. Contains Pfam match to entry FT PF00069 pkinase, Eukaryotic protein kinase domain. Contains FT PS00108 Serine/Threonine protein kinases active-site FT signature." FT /note="Similar to regions of ML0016 and ML0017" FT /db_xref="GOA:P57993" FT /db_xref="InterPro:IPR008271" FT /db_xref="UniProtKB/Swiss-Prot:P57993" FT /protein_id="CAC29812.1" FT /translation="MAESMKREHMDHDTEDVGQAAQRADPPSGTTEGRLQSTQAIFRPN FT FDDDDDLLHISVPSVDTEPQDRITPATRVLPPIRQLGGGLVEIRRVRDIDPLEALMTNP FT VVPESKRFCWNCGRPVGRSELEGQEADGAQGAKEGWCPYCGSPYSFLPQLSPGDIVAGQ FT YEVKGCIAHGGLGWVYLAFDHNVNDRPVVLKGLVHSGDAEAQASAVAERQFLAEVVHPQ FT IVQIFNFVEHKDTSGDPVGYIVMEYIGGRSLKRGSKKGNVEKLPVAEAIAYLLEILPAL FT SYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGCIYGTPGYQAPEIVRTGPT FT VATDIYTVGRTLAALTLNLRTRNGRYMDGLPEDDPVLTTYDSFARLLHRAINPDPRRRF FT SSAEEMSAQLMGVLREVVAQDTGVPRAGLSTIFSPSRSTFGVDLLVAHTDVYLDGRLHS FT EKLTAKDIVTALQVPLVDPTDVAAPVLQATVLSQPVQTLDSLRAARHGMLDAQGIDLAE FT SVELPLMEVRALLDLGDVVKANRKLDDLADRVSCQWRLVWYRAVADLLTGDYASATKHF FT TEVLNTFPGELAPKLALAATAELAGESDEHKFYRTVWHTNDGVVSAAFGLARFQSAEGD FT RTGAVCTLDEVPPTSRHFTTARLTSAVTLLSGRSTNEITEQQIRDAARRVETLPPTEPR FT VLQIRALVLGCAMDWLADNQASANHILGFPFTKHGLRLGVEASLRSLARVAPTQRHRYT FT LVDMANKVRPTSTL" FT misc_feature 43118..43693 FT /note="Pfam match to entry PF00069 pkinase, Eukaryotic FT protein kinase domain, score 91.00, E-value 3.9e-24" FT misc_feature 43493..43531 FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT repeat_region 45364..46409 FT /note="REPLEP region 3, 5'-end most similar to REPLEP 15; FT 3'-end most similar to REPLEP 14" FT repeat_region 45417..46296 FT /note="Dispersed repeat, REPLEP, copy 3" FT repeat_region 46297..46324 FT /note="28 bp subsequence of 45 bp REPLEP-associated FT sequence" FT CDS complement(46457..47901) FT /pseudo FT /transl_table=11 FT /gene="ML0305" FT /product="unknown, possible membrane protein, (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0537c (Best blastx score 503)" FT CDS 48396..49159 FT /pseudo FT /transl_table=11 FT /gene="ML0306" FT /product="possible transmembrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0538 (Best blastx score 184)" FT CDS 49500..49920 FT /pseudo FT /transl_table=11 FT /gene="ML0307" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0434 (Best blastx score 130)" FT CDS 50457..51161 FT /transl_table=11 FT /gene="ML0308" FT /product="conserved hypothetical protein" FT /note="Similar to hypothetical proteins from FT methanobacteria e.g. Methanobacterium thermoautotrophicum FT MTH1801, hypothetical protein, TR:O27829 (EMBL:AE000934) FT (224 aa); Fasta score E(): 3.6e-24, 39.3% identity in 219 FT aa overlap and Methanococcus jannaschii MJ0045, FT hypothetical protein, SW:Y045_METJA (Q60353) (221 aa); FT Fasta score E(): 4e-17, 30.5% identity in 220 aa overlap. FT Previously sequenced as TR:Q9ZBM1 (EMBL:AL035159) (234 aa); FT Fasta score E(): 0, 100.0% identity in 234 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9ZBM1" FT /protein_id="CAC29816.1" FT /translation="MISDSGIGKVVITSRGFDEYRAMFALSAMDLNATILDCPGGASSA FT TAEINAAGGRSMAVDPFYGRNLSVADLASFIQAETDRGNAYVRAHPDEYRWTFFSSPEH FT HHQSRSRAGRLFLHDYCANPSNYVEAALPRLPFSTHAFDLVLSSHLLFTYADRLSPDFH FT YQAINELMRVTRIELRIFPLVVMGSIRYDLDDLLARLRADGVHGEVVAVDYEFQAGGNQ FT MLVCSRLDGVIG" FT CDS complement(51181..53022) FT /pseudo FT /transl_table=11 FT /gene="ML0309" FT /product="ATPase of AAA-family (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0435c (Best blastx score 329)" FT CDS complement(53046..53948) FT /transl_table=11 FT /gene="pssA" FT /gene_synonym="ML0310" FT /product="putative CDP-diacylglycerol-serine FT o-phosphatidyltransferase" FT /EC_number="2.7.8.8" FT /note="Similar to M. tuberculosis pssA, Rv0436c, FT CDP-diacylglycerol-serine o-phosphatidyltransferase, FT SW:PSS_MYCTU (P96282) (286 aa); Fasta score E(): 0, 77.9% FT identity in 285 aa overlap. Similar to many e.g. FT Helicobacter pylori pssA, CDP-diacylglycerol-serine FT o-phosphatidyltransferase, SW:PSS_HELPY (Q48269) (237 aa); FT Fasta score E(): 2.3e-14, 34.6% identity in 234 aa overlap. FT Previously sequenced as TR:Q9ZBM2 (EMBL:AL035159) (300 aa); FT Fasta score E(): 0, 100.0% identity in 300 aa overlap. FT Contains Pfam match to entry PF01066 CDP-OH_P_transf, FT CDP-alcohol phosphatidyltransferase. Contains PS00379 FT CDP-alcohol phosphatidyltransferases signature." FT /db_xref="GOA:Q9ZBM2" FT /db_xref="InterPro:IPR000462" FT /db_xref="UniProtKB/Swiss-Prot:Q9ZBM2" FT /protein_id="CAC29818.1" FT /translation="MTSRPRSRRAVNLQILPSSMTVLSICAGLTSIRFALEHQPKAAIA FT LIAAAAILDGLDGRVARILGAESRMGEEIDSLADAVNFGVAPAVVLYATMLSTTPVGWV FT AVLLYPVCVVLRLARFNALLDDGTQPAYTREFFVGMPAPAGAVSVIGLLALKLQFGAGW FT WTSTWFLCIWVTGTSMLLISRIPMKKMHTVSVPPHYAAVFVAMLAIFAAAVVLAPYLLI FT WVIILTYLCHIPFAIHNQRWLAAHPEAWDDKFKQQHDARRAARRACPNRHAVPRLGLLK FT PGSRSMVRSGLRKPGRRFI" FT misc_feature complement(53271..53819) FT /note="Pfam match to entry PF01066 CDP-OH_P_transf, FT CDP-alcohol phosphatidyltransferase, score -1.50, E-value FT 0.0012" FT misc_feature complement(53712..53780) FT /note="PS00379 CDP-alcohol phosphatidyltransferases FT signature" FT CDS complement(53945..54676) FT /transl_table=11 FT /gene="ML0311" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis psd, Rv0437c, putative FT phosphatidylserine decarboxylase, TR:O86324 (EMBL:AL123456) FT (231 aa); Fasta score E(): 0, 72.6% identity in 241 aa FT overlap. Similar to many bacterial hypothetical proteins FT e.g. Rickettsia prowazekii RP241, hypothetical protein, FT TR:Q9ZDT4 (EMBL:AJ235271) (231 aa); Fasta score E(): FT 5.2e-31, 43.3% identity in 215 aa overlap and Neisseria FT meningitidis MC58 NMB0963, phosphatidylserine decarboxylase FT precursor-related protein, TR:AAF41369 (EMBL:AE002447) (265 FT aa); Fasta score E(): 2.5e-23, 39.2% identity in 217 aa FT overlap. Previously sequenced as TR:Q9ZBM3 (EMBL:AL035159) FT (202 aa); Fasta score E(): 0, 99.5% identity in 202 aa FT overlap. The start codon is uncertain. Codon usage suggests FT an alternative start at codon 63 (approx)." FT /db_xref="GOA:Q9CCW9" FT /db_xref="InterPro:IPR004428" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCW9" FT /protein_id="CAC29819.1" FT /translation="MARRPRAESSKEGPAHLLELVRSAVPPVHSAGHPFISAGLAVTSA FT GAVGQVVTGRDLRWLRRVGLLAASACAVFFRHPSRVPPTRAGVVVAPADGMICVIDSAT FT PPAELSMGNMSLPRVSIFLSLLDVHVQRAPISGEVIAVQYQPGRFGAADLAPASTENER FT TSVRIRTAGGTEVVVVQIAGLLARRIVCYAHIGDKLTIGDTYGLIRFGSRLDTYLPPGT FT EPVVQVGQRAVAGETVLADLT" FT CDS complement(54720..55953) FT /pseudo FT /transl_table=11 FT /gene="moaA3" FT /gene_synonym="ML0312" FT /product="molybdenum cofactor biosynthesis, protein A FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT moaA3 (Best blastx score 245)" FT CDS complement(56042..56675) FT /pseudo FT /transl_table=11 FT /gene="ML0313" FT /product="probable oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0439c (Best blastx score 248)" FT CDS complement(56771..57778) FT /transl_table=11 FT /gene="ML0314" FT /product="putative esterase" FT /note="Similar to M. tuberculosis lipU, Rv1076, probable FT esterase, TR:O53424 (EMBL:AL123456) (297 aa); Fasta score FT E(): 0, 79.7% identity in 296 aa overlap. Also similar to FT other putative esterases from M. tuberculosis. Similar to FT esterases e.g. Streptomyces hygroscopicus bah, FT acetyl-hydrolase, SW:BAH_STRHY (Q01109) (299 aa); Fasta FT score E(): 6.6e-19, 36.2% identity in 246 aa overlap. FT Previuosly sequenced as TR:Q9ZBM4 (EMBL:AL035159) (335 aa); FT Fasta score E(): 0, 99.7% identity in 335 aa overlap. FT Contains PS01174 Lipolytic enzymes 'G-D-X-G' family, FT putative serine active site." FT /db_xref="GOA:Q9ZBM4" FT /db_xref="InterPro:IPR013094" FT /db_xref="UniProtKB/TrEMBL:Q9ZBM4" FT /protein_id="CAC29822.1" FT /translation="MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLP FT WPFGLIDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGGAFLG FT CGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPEQIV FT LAGDSAGGYLALALAQRLQDVGEEPAALVAISPLLQLAKKGKQAHPNAKTDAMFPPKAF FT DALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLA FT AVGVPAEIRVWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL" FT misc_feature complement(57257..57295) FT /note="PS01174 Lipolytic enzymes 'G-D-X-G' family, putative FT serine active site" FT CDS complement(59698..60612) FT /transl_table=11 FT /gene="ML0315" FT /product="putative oxidoreductase" FT /note="Similar to M. tuberculosis Rv0068, putative FT oxidoreductase, TR:O53613 (EMBL:AL123456) (303 aa); Fasta FT score E(): 0, 73.9% identity in 306 aa overlap and to other FT M. tuberculosis putative oxidoreductases (e.g. Rv0439c). FT Similar to many bacterial putative oxidoreductases e.g. FT Streptomyces coelicolor SC7A8.30C, putative oxidoreductase, FT TR:CAB69779 (EMBL:AL137187) (310 aa); Fasta score E(): 0, FT 47.9% identity in 311 aa overlap. Previously sequenced as FT TR:Q9ZBM5 (EMBL:AL035159) (304 aa); Fasta score E(): 0, FT 100.0% identity in 304 aa overlap. Contains Pfam match to FT entry PF00106 adh_short, short chain dehydrogenase." FT /db_xref="GOA:Q9ZBM5" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9ZBM5" FT /protein_id="CAC29823.1" FT /translation="MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLAV FT RNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDYDHIDLLINNAGVM FT WTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRVITVSSLSHRLFADIHFND FT LQWECNYNRVAAYGQSKLANLLFTYELQRRLATRQTTIAVAAHPGGSRTELTRTLPALI FT APIFSVAELFLTQDAATGALPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSH FT DVDRQLRLWAVSEELTGVVYPVG" FT misc_feature complement(59974..60570) FT /note="Pfam match to entry PF00106 adh_short, short chain FT dehydrogenase, score 95.90, E-value 7.9e-25" FT RBS complement(60619..60623) FT /note="possible RBS" FT CDS 60707..61309 FT /transl_table=11 FT /gene="ML0316" FT /product="putative TetR/AcrR-family transcriptional FT regulator" FT /note="Similar to M. tuberculosis Rv0067c, putative FT transcriptional regulator, TR:O53612 (EMBL:AL123456) (189 FT aa); Fasta score E(): 0, 68.8% identity in 189 aa overlap. FT Similar to many putative transcriptional regulators e.g. FT Streptomyces coelicolor SCF6.16, putative tetR family FT transcriptional regulator, TR:Q9RJL5 (EMBL:AL121849) (194 FT aa); Fasta score E(): 2.5e-18, 39.5% identity in 185 aa FT overlap. Previously sequenced as TR:Q9ZBM6 (EMBL:AL035159) FT (189 aa); Fasta score E(): 0, 100.0% identity in 189 aa FT overlap. Contains a probable helix-turn-helix motif at aa FT 45-66 (Score 1800, SD +5.32) Contains Pfam match to entry FT PF00440 tetR, Bacterial regulatory proteins, tetR family." FT /db_xref="GOA:Q9CCW8" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q9CCW8" FT /protein_id="CAC29824.1" FT /translation="MSVPRSGLSVQMAQPARPLRADAARNRARILGVAYEAFATEGLSV FT PIDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDDGYVLLKSAGPGEALFTYL FT RSLVLHWGATDRGLVDALAGAGGIDILGVAPDAEDAFLTILSDLLYAAQYAGTARTDVG FT VREVKSILVGCQAMEAYNSALAERVTDVVVDGLRAAR" FT misc_feature 60794..60931 FT /note="Pfam match to entry PF00440 tetR, Bacterial FT regulatory proteins, tetR family, score 62.00, E-value FT 1.3e-14" FT RBS 61501..61505 FT /note="possible RBS" FT CDS 61518..63143 FT /transl_table=11 FT /gene="groEL2" FT /gene_synonym="ML0317" FT /product="60 kDa chaperonin 2" FT /note="Similar to M. tuberculosis groEL2, Rv0440, 60 kDa FT chaperonin 2, SW:CH62_MYCTU (P06806) (539 aa); Fasta score FT E(): 0, 94.8% identity in 541 aa overlap. A major FT immunoreactive protein (65 kDa antigen). Previously FT sequenced as SW:CH62_MYCLE (P09239) (540 aa); Fasta score FT E(): 0, 100.0% identity in 540 aa overlap. Contains Pfam FT match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin FT family. Contains PS00296 Chaperonins cpn60 signature." FT /note="Similar to ML0381" FT /db_xref="GOA:P09239" FT /db_xref="HSSP:1IOK" FT /db_xref="InterPro:IPR002423" FT /db_xref="UniProtKB/Swiss-Prot:P09239" FT /protein_id="CAC29825.1" FT /translation="MAKTIAYDEEARRGLERGLNSLADAVKVTLGPKGRNVVLEKKWGA FT PTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLR FT NVAAGANPLGLKRGIEKAVDKVTETLLKDAKEVETKEQIAATAAISAGDQSIGDLIAEA FT MDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDAERQEAVLEEPYILLVS FT SKVSTVKDLLPLLEKVIQAGKSLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGD FT RRKAMLQDMAILTGAQVISEEVGLTLENTDLSLLGKARKVVMTKDETTIVEGAGDTDAI FT AGRVAQIRTEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVR FT NAKAAVEEGIVAGGGVTLLQAAPALDKLKLTGDEATGANIVKVALEAPLKQIAFNSGME FT PGVVAEKVRNLSVGHGLNAATGEYEDLLKAGVADPVKVTRSALQNAASIAGLFLTTEAV FT VADKPEKTAAPASDPTGGMGGMDF" FT misc_feature 61581..63083 FT /note="Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 FT chaperonin family, score 777.80, E-value 4.3e-230" FT misc_feature 62724..62759 FT /note="PS00296 Chaperonins cpn60 signature" FT repeat_region 63378..64126 FT /note="Dispersed repeat, RLEP, copy 6" FT CDS complement(64187..65345) FT /pseudo FT /transl_table=11 FT /gene="radA" FT /gene_synonym="ML0318" FT /product="probable DNA repair RadA homologue (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT radA (Best blastx score 221)" FT CDS complement(65442..65993) FT /transl_table=11 FT /gene="lpqE" FT /gene_synonym="ML0319" FT /product="putative lipoprotein" FT /note="Similar to M. tuberculosis lpqE, Rv3584, putative FT lipoprotein, TR:O53569 (EMBL:AL123456) (182 aa); Fasta FT score E(): 0, 63.4% identity in 175 aa overlap. Previously FT sequenced as TR:Q9ZBM7 (EMBL:AL035159) (183 aa); Fasta FT score E(): 0, 99.5% identity in 183 aa overlap. Contains a FT probable N-terminal signal sequnce. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q9ZBM7" FT /db_xref="UniProtKB/Swiss-Prot:Q9ZBM7" FT /protein_id="CAC29827.1" FT /translation="MSRFKISLPALATRVAVLGFLTLMASVLGGCGAGQISQTATQEPA FT VNGNRVTLNNLALRDIRIQAAQTGDFLQSGRTVDLMLVAINNSPYVTDRLVSITSDIGT FT VALNGYTQLPTNGMLFIGTSEGQRIKPPPLQSNNIAKAIVTLAKPITNGLTYNFTFNFE FT KAGQANVAVPVSAGLAPRQT" FT misc_feature complement(65901..65933) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT RBS complement(66000..66005) FT /note="possible RBS" FT CDS 66354..66851 FT /transl_table=11 FT /gene="ML0320" FT /product="putative transcription factor" FT /note="Similar to M. tuberculosis Rv3583c, putative FT transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); FT Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows FT weak similarity to Myxococcus xanthus carD, transcription FT factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): FT 9.1e-13, 31.2% identity in 154 aa overlap and to many FT hypothetical transcription factors." FT /db_xref="GOA:Q9CCW7" FT /db_xref="InterPro:IPR003711" FT /db_xref="UniProtKB/TrEMBL:Q9CCW7" FT /protein_id="CAC29828.1" FT /translation="MNLMIFKVGDTVVYPHHGAALVEAIETRTINGEQKEYLVLKVAQG FT DLTVRVPAENAEYVGVRDVVGQEGLDQVFQVLRAPHTEEPTNWSRRYKANLEKLASGDV FT NKVSEVVRDLWRRDQDRGLSAGEKRMLAKARQILVGELALAESTDDAKAETILDEVLAA FT AS" FT RBS 66859..66862 FT /note="possible RBS" FT CDS 66870..67595 FT /transl_table=11 FT /gene="ML0321" FT /product="putative FT 4-diphosphocytidyl-2C-methyl-D-erythritol synthase" FT /note="Similar to M. tuberculosis Rv3582c, conserved FT hypothetical protein, SW:YZ82_MYCTU (P96864) (231 aa); FT Fasta score E(): 0, 66.0% identity in 241 aa overlap. FT Similar to many bacterial hypothetical proteins e.g. FT Streptomyces coelicolor SCD8A.06, hypothetical protein, FT TR:CAB77327 (EMBL:AL160331) (270 aa); Fasta score E(): FT 4.3e-25, 45.0% identity in 240 aa overlap. Shows weak FT similarity to non-mevalonate pathway enzyme FT 4-diphosphocytidyl-2C-methyl-D-erythritol synthases e.g. FT Escherichia coli ispD, FT 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, FT TR:AAF43207 (EMBL:AF230736) (236 aa); Fasta score E(): FT 0.0016, 36.1% identity in 244 aa overlap. Contains Pfam FT match to entry PF01128 UPF0007, Uncharacterized protein FT family UPF0007." FT /db_xref="GOA:Q9CCW6" FT /db_xref="HSSP:1I52" FT /db_xref="InterPro:IPR018294" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCW6" FT /protein_id="CAC29829.1" FT /translation="MAVATGTVVAVVPAAGAGKRLAAGIPKAFCELDGRTLVERAVVGL FT LESGVVDHVVVAVPADRIAQTQWVLSQRLANSAGQHATVVAGGADRTKSVCQALATLPA FT PSRVGAPEFILVHDAARALTPARLIVRVVDALRAGHTAVVPALPLSDTIKAVDANGMVL FT GTPARVGLRAVQTPQGFATELLWCAYQRGPHLDAVDFTDDASLVEHLGGQVQVVAGDPL FT AFKITTQLDLLLAKKILRR" FT misc_feature 66891..67592 FT /note="Pfam match to entry PF01128 UPF0007, Uncharacterized FT protein family UPF0007, score 293.70, E-value 2.3e-84" FT CDS 67592..68068 FT /transl_table=11 FT /gene="ML0322" FT /product="putative 2-C-methyl-D-erythritol FT 2,4-cyclodiphosphate synthase" FT /note="Similar to M. tuberculosis Rv3581c, hypothetical FT protein, SW:YZ81_MYCTU (P96863) (159 aa); Fasta score E(): FT 0, 79.1% identity in 158 aa overlap. Similar to FT 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthases, FT e.g. Escherichia coli 2-C-methyl-D-erythritol FT 2,4-cyclodiphosphate synthase, TR:BAA95145 (EMBL:AB038256) FT (159 aa); Fasta score E(): 1e-17, 41.3% identity in 155 aa FT overlap. Contains Pfam match to entry PF01128 UPF0007, FT Uncharacterized protein family UPF0007." FT /db_xref="GOA:Q9CCW5" FT /db_xref="HSSP:1IV2" FT /db_xref="InterPro:IPR003526" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCW5" FT /protein_id="CAC29830.1" FT /translation="MSELPRVGLGFDVHVFEPGRPCWLVGLLFPDNDGCAGHSDGDVAV FT HALCDAVLSAAGQGDIGGLFAVGDPRWERVSGADMLRHVVELLLRHGYEVVNASVQVIG FT NRPKIGPRRTEAQRLLSALLRAPVSVAATTTEGLGLTGRGEGLSAIATALVVQV" FT CDS 68123..69544 FT /transl_table=11 FT /gene="cysS" FT /gene_synonym="ML0323" FT /product="putative cysteinyl-tRNA synthase" FT /EC_number="6.1.1.16" FT /note="Similar to M. tuberculosis cysS, Rv3580c, FT cysteinyl-tRNA synthetase, SW:SYC1_MYCTU (P96862) (469 aa); FT Fasta score E(): 0, 86.5% identity in 467 aa overlap. FT Similar to many e.g. Escherichia coli cysS, cysteinyl-tRNA FT synthetase, SW:SYC_ECOLI (P21888) (461 aa); Fasta score FT E(): 0, 42.0% identity in 460 aa overlap. Contains Pfam FT match to entry PF01406 tRNA-synt_1e, tRNA synthetases class FT I (C)." FT /note="Similar to ML1302" FT /db_xref="GOA:P57990" FT /db_xref="HSSP:1LI5" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:P57990" FT /protein_id="CAC29831.1" FT /translation="MIDSGHLRLHDTVAGAVRDFVPLRAGHVSIYLCGATVQGQPHIGH FT VRSGVAFDILRRWLMARGYDVAFIRNVTDIDDKILNKAAAAGRPWWEWAATHERAFTAA FT YDALDVLPPSAEPRATGHITQMIELIELLIETGHAYTGGSDVYFDVLSYPDYGQLSGHK FT MDYIHQGEGVTTGKRDQRDFTLWKGAKSGEPSWPTPWGRGRPGWHLECSAMARAYLGSE FT FDIHCGGMDLVFPHHENEIAQSRAVGDGFARYWLHNGWVTMGGEKMSKSLGNVLSIPAV FT LQRVRPAELRYYLGSAHYRSMLEFSEAALQDAVKAYVGVENFLTRVRTRVGAVGTGELT FT PRFAAALDDDLAVPIALAEVHHARVEGNRALDIGDHEGALTNAGAIRAMMGILGCDPLD FT ERWESRDETSAALAAVDVLVAAELESRQMAREQRNWVLADQIRDRLKDAGIEVTDTVNG FT PQWELLAGDKQVDAR" FT misc_feature 68177..69472 FT /note="Pfam match to entry PF01406 tRNA-synt_1e, tRNA FT synthetases class I (C), score 815.60, E-value 1.8e-241" FT CDS 69627..70463 FT /transl_table=11 FT /gene="ML0324" FT /product="putative methyltransferase" FT /note="Similar to M. tuberculosis Rv3579c, putative FT methyltransferase, TR:P96861 (EMBL:AL123456) (322 aa); FT Fasta score E(): 0, 84.1% identity in 277 aa overlap. FT Similar Streptomyces actuosus nhs, 23S rRNA FT methyltransferase and to many hypothetical rRNA FT methyltransferases. Contains Pfam match to entry PF00588 FT SpoU_methylase, SpoU rRNA Methylase family." FT /db_xref="GOA:Q9CCW4" FT /db_xref="HSSP:1GZ0" FT /db_xref="InterPro:IPR013123" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCW4" FT /protein_id="CAC29832.1" FT /translation="MEGRGPTPPAYLRPNHPAAKRNQSSPHRPVKRTDETETVLGRNPV FT LECLRAGVPATALYVALGTEVDKRLTESVMRAADVGVAILEVPRTYLDRITNNHLHQGI FT ALQVPPYHYVHSDDLLAAATDSPPALLVALDNISDPRNLGAIVRSVAAFSGHGILIPQR FT RSASVTAVAWRTSAGAAARIPVARATNLTRALKVWADQGLRVIGLDHDGDTALDDLDGT FT DPLAVVVGSEGKGLSRLVRHSCDEVVSIPMAGQVESLNASVAVGVVLAEIARQRRL" FT misc_feature 70011..70436 FT /note="Pfam match to entry PF00588 SpoU_methylase, SpoU FT rRNA Methylase family, score 159.60, E-value 5.2e-44" FT RBS 70843..70848 FT /note="possible RBS" FT CDS 70865..71128 FT /transl_table=11 FT /gene="ML0325" FT /product="hypothetical protein" FT /note="Unknown function. Possibly the remains of a FT disrupted gene." FT /db_xref="UniProtKB/TrEMBL:Q9CCW3" FT /protein_id="CAC29833.1" FT /translation="MLRGNKIVVLPEVFALTDYYLADVRFNIETKVAADRPAVSVFSQE FT FVDVVLAVVRSVGKVDRVASPGERPADGASGLAVYTVGGLMG" FT stem_loop complement(71215..71269) FT /note="55 bp palindrome" FT CDS complement(72569..72845) FT /pseudo FT /transl_table=11 FT /gene="ML0326" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0288 (Best blastx score 118)" FT CDS complement(72866..73152) FT /pseudo FT /transl_table=11 FT /gene="ML0327" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0287 (Best blastx score 124)" FT CDS complement(73242..74418) FT /pseudo FT /transl_table=11 FT /gene="PPE" FT /gene_synonym="ML0328" FT /product="PPE-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0286, PPE (Best blastx score 169)" FT CDS complement(76549..76876) FT /pseudo FT /transl_table=11 FT /gene="ML0329" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1942c (Best blastx score 168)" FT CDS complement(76876..76989) FT /pseudo FT /transl_table=11 FT /gene="ML0330" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1943c (Best blastx score 154)" FT CDS complement(77105..78310) FT /pseudo FT /transl_table=11 FT /gene="arsB2" FT /gene_synonym="ML0331" FT /product="probable arsenical pump (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT arsB2 (Best blastx score 423)" FT repeat_region complement(77979..78252) FT /note="274 bp repeat, 99% identity to 2828540..2828813" FT CDS complement(78317..79055) FT /pseudo FT /transl_table=11 FT /gene="ML0332" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3577 (Best blastx score 257)" FT CDS complement(79178..79936) FT /transl_table=11 FT /gene="ML0333" FT /product="conserved hypothetical protein" FT /note="N-terminal half is similar to that of Emericella FT nidulans lamB, lactam utilization protein, SW:LAMB_EMENI FT (P38096) (262 aa); Fasta score E(): 2.6e-15, 38.3% identity FT in 128 aa overlap. Similar to many bacterial hypothetical FT proteins e.g. TR:Q9RL45 (EMBL:AL121596) (250 aa); Fasta FT score E(): 0, 58.1% identity in 248 aa overlap." FT /db_xref="InterPro:IPR005501" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCW2" FT /protein_id="CAC29841.1" FT /translation="MACIDLNADLGEGFGVWRLGDDEAMLRIVTSANVACGFHAGDPAG FT LLRVCRLAAERGVRIGAQVSYRDLVGFGRRFIDVTADDLLADVVYQIGALQAIAQTAGS FT AVSYVKPHGALYNTIVTNREQGAAVAAAIQLVDSTLPVLGLAGSTFFDEAARIGLRTVA FT EAFADRTYRPDGQLISRREPGAVLHDPAVIAQRVVTMVTTGKATAVDGTQLAVTVESIC FT LHGDSPNAIQMATAVRDQLNAAGIDIRAFC" FT CDS complement(80106..80678) FT /pseudo FT /transl_table=11 FT /gene="pknM" FT /gene_synonym="ML0334" FT /product="similar to ser-thr-protein kinases (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pknM (Best blastx score 208)" FT CDS complement(80867..81727) FT /transl_table=11 FT /gene="ML0335" FT /product="putative ABC-transporter transmembrane protein" FT /note="Similar in part to M. tuberculosis Rv2060, conserved FT hypothetical protein, TR:O86339 (EMBL:AL123456) (133 aa); FT Fasta score E(): 0, 80.3% identity in 132 aa overlap. FT Similar, except N-terminal approx. 100 aa to many bacterial FT ABC transporters e.g. Streptococcus pneumoniae adcB, FT putative ABC metal permease, TR:O33704 (EMBL:Z71552) (268 FT aa); Fasta score E(): 2.5e-15, 26.6% identity in 263 aa FT overlap. Contains hydrophobic, possible membrane-spanning FT regions. Contains Pfam match to entry PF00950 ABC-3, ABC 3 FT transport family." FT /db_xref="GOA:Q9CCW1" FT /db_xref="InterPro:IPR001626" FT /db_xref="UniProtKB/TrEMBL:Q9CCW1" FT /protein_id="CAC29843.1" FT /translation="MDDRLAHMWNHLFSFDITTHLLSHNFVQQALLAALLLGLVAGLIG FT PFIVMRQMSFAVHGSSELSLTGATFALLAGFEMGVGALVGSALAATLFGILGRRARERD FT SVIGVVLAFGLGLAVLFIHLYPGRTGTSLALLTGQIIDVGYSGLATLALVCLFVIAVLT FT TCYRPLLFATVDPEVAAACGVPVHALGIVFAALVGLVAAQAVQVVGALLVMSLLITPAA FT AAAQVVASPVAAMVAAVIFAEVSAVGGVVLSLAPGVPVSVFVATISFLIYLFCWLLGRH FT REVCA" FT misc_feature complement(80891..81661) FT /note="Pfam match to entry PF00950 ABC-3, ABC 3 transport FT family, score 95.40, E-value 1.1e-24" FT CDS complement(81727..82554) FT /transl_table=11 FT /gene="ML0336" FT /product="putative ABC-tranporter ATP-binding protein" FT /note="Similar to many putative ABC-tranporter ATP-binding FT proteins e.g. Chlamydia trachomatis troB, ABC transporter FT ATPase, TR:O87477 (EMBL:AF077010) (286 aa); Fasta score FT E(): 4.7e-16, 31.4% identity in 223 aa overlap. Contains FT Pfam match to entry PF00005 ABC_tran, ABC transporter. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT Contains PS00211 ABC transporters family signature." FT /db_xref="GOA:Q9CCW0" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:Q9CCW0" FT /protein_id="CAC29844.1" FT /translation="MAVENLDAVSRRPQSADNDARTISLSGARLAFGDQTLWDHLDLSV FT SAGEFIAVLGPNGTGKTSLLKVLLGQLELSAGVARVEGKRITAGSPRIGYVPQHRPIDR FT EVLLRGRDLVRLGIDGRRWGALPLRSADRARRREAVFTALQQVNGEQLADVRVGVMSGG FT ELQRIRIAQALVNDPTLLLCDEPLLTLDPANAKLVSTLIDRRRREAGTTVLVVTHEINP FT LLPYVDRVLYLVDGRFLIGTVEQVMTTERLSTLYQANIRVVKVEDHYIVVGEP" FT misc_feature complement(81847..82413) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 148.40, E-value 1.2e-40" FT misc_feature complement(82033..82077) FT /note="PS00211 ABC transporters family signature" FT misc_feature complement(82369..82392) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(82563..83471) FT /transl_table=11 FT /gene="ML0337" FT /product="putative periplasmic solute-binding proteins" FT /note="Shows weak similarity to periplasmic solute-binding FT proteins e.g. Synechocystis sp. (strain PCC 6803) mntC, FT periplasmic-binding protein, TR:Q55280 (EMBL:L34630) (330 FT aa); Fasta score E(): 0.0001, 26.4% identity in 178 aa FT overlap. Contains a possible N-terminal signal sequence. FT Contains Pfam match to entry PF01297 Lipoprotein_4, FT Adhesion lipoprotein. Contains PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site." FT /db_xref="GOA:Q9CCV9" FT /db_xref="InterPro:IPR006127" FT /db_xref="UniProtKB/TrEMBL:Q9CCV9" FT /protein_id="CAC29845.1" FT /translation="MRWLTTIILCLISSTVAGGCGSLSSGHLRPTAVVASTDVWGSVAR FT IIAGRHVAVTSIVTGAHTDPHTYRVNPAETAAITDAALVVYNGGGYDPWVDKVLAGRPD FT IKSVDAYSLLASRGATTEGPADEHVFYDLNIAKSVASLIADQLVTIDPDNAADYQANAT FT EFCRSADAIAISEHAIASDYPAAGVIVTEPVVHYLLQASGLVNRTPPAFTATHENENDP FT SAADMAAALNLINHRQVSALLVNPQKSNAATNGLQAAARRSGVPVTEVTEMLPNDTDYL FT TWQRNTIDQLLTALQSNRSPR" FT misc_feature complement(82584..83450) FT /note="Pfam match to entry PF01297 Lipoprotein_4, Adhesion FT lipoprotein, score 2.70, E-value 4.5e-10" FT misc_feature complement(83412..83444) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 83651..84675 FT /pseudo FT /transl_table=11 FT /gene="ML0338" FT /product="transcriptional regulator (LacI family) FT (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT orthologue Rv3575c (Best blastx score 220)" FT CDS complement(84887..85249) FT /pseudo FT /transl_table=11 FT /gene="ML0339" FT /product="transcriptional regulator (TetR/AcrR family) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3574 (Best blastx score 269)" FT CDS 85653..87495 FT /pseudo FT /transl_table=11 FT /gene="fadE34" FT /gene_synonym="ML0340" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE34 (Best blastx score 539)" FT CDS complement(87727..88218) FT /pseudo FT /transl_table=11 FT /gene="ML0341" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3572 (Best blastx score 324)" FT CDS complement(88323..89323) FT /pseudo FT /transl_table=11 FT /gene="ML0342" FT /product="electron transfer component of (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3571 (Best blastx score 484)" FT CDS 89560..90728 FT /pseudo FT /transl_table=11 FT /gene="ML0343" FT /product="putative oxidoreductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3570c (Best blastx score 413)" FT CDS 90746..91270 FT /pseudo FT /transl_table=11 FT /gene="ML0344" FT /product="probable hydrolase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3569c (Best blastx score 339)" FT CDS complement(91602..92741) FT /pseudo FT /transl_table=11 FT /gene="ML0345" FT /product="lipid carrier protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3523 (Best blastx score 319)" FT CDS complement(92783..93194) FT /pseudo FT /transl_table=11 FT /gene="ML0346" FT /product="putative transcriptional regulator (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3522 (Best blastx score 167)" FT CDS complement(93391..93981) FT /pseudo FT /transl_table=11 FT /gene="ML0347" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3521 (Best blastx score 236)" FT CDS 94262..95314 FT /transl_table=11 FT /gene="ML0348" FT /product="possible coenzyme F420-dependent oxidoreductase" FT /note="Similar to M. tuberculosis Rv3520c, possible FT coenzyme F420-dependent enzyme, TR:O53565 (EMBL:AL123456) FT (347 aa); Fasta score E(): 0, 86.8% identity in 342 aa FT overlap. Shows weak similarity to Methanobacterium FT thermoautotrophicum mer, methylenetetrahydromethanopterin FT reductase, TR:Q50744 (EMBL:X86477) (321 aa); Fasta score FT E(): 2.8e-05, 27.1% identity in 332 aa overlap." FT /db_xref="GOA:Q9CCV8" FT /db_xref="InterPro:IPR019951" FT /db_xref="UniProtKB/TrEMBL:Q9CCV8" FT /protein_id="CAC29856.1" FT /translation="MVERANAMKLGLQLGYWAAQPPGNAAELVAAAEGAGFDAVFTGEA FT WGSDAYTPLAWWGSSTQRVRLGTSVVQLSARTPTACAMAALTLDHLSGGRHILGLGVSG FT PQVVEGWYGQPFPKPLSRTREYIDIVRQVWAREAPVVSDGQHYPLPLTGAGATGLGKAL FT KPITHPLRADIPIMLGAEGPKNVALAAEICDGWLPIFFSPRMADMYNEWLDEGFARTGA FT RRSREDFEICASAQIVVTEDRAAAFAGIKPFLALYMGGMGAEGTNFHADVYRRMGYAEV FT VDEVTALFRSNQKDKAAEIIPNELVDSTMIVGDVDYVCKQIAAWSAAGVTMMMVSASSV FT EQVRDLAGLF" FT CDS complement(95393..95704) FT /pseudo FT /transl_table=11 FT /gene="ML0349" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3519 (Best blastx score 156)" FT CDS complement(98415..99185) FT /pseudo FT /transl_table=11 FT /gene="ML0350" FT /product="probable transferase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv3729 (Best blastx score 294)" FT CDS complement(100087..100737) FT /pseudo FT /transl_table=11 FT /gene="echA19" FT /gene_synonym="ML0351" FT /product="enoyl-CoA hydratase/isomerase superfamily FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT echA19 (Best blastx score 238)" FT CDS 100860..101795 FT /pseudo FT /transl_table=11 FT /gene="fadD19" FT /gene_synonym="ML0352" FT /product="acyl-CoA synthase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadD19 (Best blastx score 221)" FT CDS 102609..103405 FT /pseudo FT /transl_table=11 FT /gene="ML0353" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3510c (Best blastx score 461)" FT RBS 103402..103406 FT /note="possible RBS" FT CDS 103414..104961 FT /transl_table=11 FT /gene="ilvX" FT /gene_synonym="ML0354" FT /product="putative acetohydroxyacid synthase I large FT subunit" FT /note="Similar to M. tuberculosis ilvX, putative FT acetohydroxyacid synthase I large subunit, TR:O53554 FT (EMBL:AL123456) (515 aa); Fasta score E(): 0, 82.9% FT identity in 515 aa overlap. Similar to Escherichia coli FT ilvI, acetolactate synthase isozyme III large subunit, FT SW:ILVI_ECOLI (P00893) (574 aa); Fasta score E(): 1.8e-07, FT 23.7% identity in 540 aa overlap. Also similar to FT Pseudomonas putida mdlC, benzoylformate decarboxylase, FT SW:MDLC_PSEPU (P20906) (528 aa); Fasta score E(): 6.6e-13, FT 29.3% identity in 529 aa overlap. Previously sequenced as FT TR:Q49865 (EMBL:U00020) (515 aa); Fasta score E(): 0, 99.8% FT identity in 515 aa overlap. Contains 2 Pfam matches to FT entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes." FT /db_xref="GOA:Q49865" FT /db_xref="InterPro:IPR012001" FT /db_xref="UniProtKB/TrEMBL:Q49865" FT /protein_id="CAC29862.1" FT /translation="MNGAQAMISTLVDGGVDVCFANPGTSEMHFVAALDTVAGMRGVLT FT LFEGVATGAADGYARIAGRPAVVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH FT KKYDAPLESDIDALAGTVSGWLHRTMDTADVGVDAAEAISASLVGSQISTLILPADVSW FT SDGAIPAASVSDQPASAGVDVGAVRTALESGEPTVILIGADATGWSGLAAVARIGAATG FT ARWFCETFPARLERGAGVPAVERLAYFAEVAAAQLDGAKHLVLAGAQSPVSFFAYPGMP FT SDLVPAGCEVHVLAEHGGAAYALNALADEVASGTAAPVVAASRPQLPSGPLTSGAAANV FT IGALLPERAIVVDESNTSGVLLAAATAGAPAHDWLTLTGGAIGHGIPASVGAAVAAPDR FT PVLCLESDGSAMYTISGLWTQARENLDVTTIIYNNGAYNILRIELQRMGAGSTPGPKAL FT SLLDLSSPTMDFVKIAEGMGVSARRVNTTEGLADALRLAFTEPGPHLIDTVVPSIVG" FT misc_feature 103444..103710 FT /note="Pfam match to entry PF00205 TPP_enzymes, Thiamine FT pyrophosphate enzymes, score 47.60, E-value 3.5e-14" FT misc_feature 104551..104937 FT /note="Pfam match to entry PF00205 TPP_enzymes, Thiamine FT pyrophosphate enzymes, score 94.50, E-value 9.3e-29" FT CDS complement(105015..106183) FT /pseudo FT /transl_table=11 FT /gene="fadD17" FT /gene_synonym="ML0355" FT /product="acyl-CoA synthase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadD17 (Best blastx score 515)" FT CDS complement(106363..107273) FT /pseudo FT /transl_table=11 FT /gene="fadE27" FT /gene_synonym="ML0356" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE27 (Best blastx score 223)" FT CDS complement(107302..108424) FT /pseudo FT /transl_table=11 FT /gene="fadE26" FT /gene_synonym="ML0357" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE26 (Best blastx score 551)" FT CDS 108646..108816 FT /pseudo FT /transl_table=11 FT /gene="ML0358" FT /product="putative ferredoxin (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fdxD (Best blastx score 212)" FT CDS 108939..109841 FT /pseudo FT /transl_table=11 FT /gene="ML0359" FT /product="putative dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3502c (Best blastx score 300)" FT CDS 110075..110785 FT /pseudo FT /transl_table=11 FT /gene="ML0360" FT /product="part of mce4 operon (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3501c (Best blastx score 493)" FT CDS 110840..111649 FT /pseudo FT /transl_table=11 FT /gene="ML0361" FT /product="part of mce4 operon (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3500c (Best blastx score 393)" FT CDS 111770..112328 FT /pseudo FT /transl_table=11 FT /gene="mce4" FT /gene_synonym="ML0362" FT /product="cell invasion protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT mce4 (Best blastx score 195)" FT CDS 112418..112732 FT /transl_table=11 FT /gene="ML0363" FT /product="possible secreted protein" FT /note="Similar to M. tuberculosis Rv3444c, esat6-family FT protein, TR:O06261 (EMBL:Al123456) (100 aa); Fasta score FT E(): 3.3e-20, 71.2% identity in 73 aa overlap and others of FT the esat6 family e.g. esat6 itself, 6 kDa early secretory FT antigenic target, SW:ESA6_MYCTU (Q57165) (94 aa); Fasta FT score E(): 1.5, 28.4% identity in 67 aa overlap." FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/TrEMBL:Q9CCV7" FT /protein_id="CAC29871.1" FT /translation="MGEVARGSGVVLTAPTKSNTPLAGKSTARPARFNAALEELRSQIA FT PLQQRWIRAAVVVYPVEQLKWHQAATALNEILVDLGNVIRAGAEEVANTDRRSGGVWAG FT " FT RBS 112971..112976 FT /note="possible RBS" FT CDS 112984..113427 FT /transl_table=11 FT /gene="rplM" FT /gene_synonym="ML0364" FT /product="50S ribosomal protein L13" FT /note="Similar to M. tuberculosis rplM, 50S ribosomal FT protein L13, SW:RL13_MYCTU (O06260) (147 aa); Fasta score FT E(): 0, 91.2% identity in 147 aa overlap. Previuosly FT sequenced as SW:RL13_MYCLE (P38014) (147 aa); Fasta score FT E(): 0, 99.3% identity in 147 aa overlap. Contains Pfam FT match to entry PF00572 Ribosomal_L13, Ribosomal protein FT L13. Contains PS00783 Ribosomal protein L13 signature." FT /db_xref="GOA:P38014" FT /db_xref="InterPro:IPR005823" FT /db_xref="UniProtKB/Swiss-Prot:P38014" FT /protein_id="CAC29872.1" FT /translation="MPTYAPKAGDTTCSWYVIDATDVVLGRLAAVAATLLRGKHKPTFA FT PNVDGGDFVIVINADKVAISGDKVQHKMVYRHSGYPGGLRKRTIGELMQKHPDRVVEKA FT IVGMLPKNKLSRQIQRKLRVYAGPDHPHSAQQPVPFEIKQVAQ" FT misc_feature 113026..113409 FT /note="Pfam match to entry PF00572 Ribosomal_L13, Ribosomal FT protein L13, score 289.30, E-value 4.7e-83" FT misc_feature 113296..113364 FT /note="PS00783 Ribosomal protein L13 signature" FT CDS 113424..113885 FT /transl_table=11 FT /gene="rpsI" FT /gene_synonym="ML0365" FT /product="30S ribosomal protein S9" FT /note="Similar to M. tuberculosis rpsI, 30S ribosomal FT protein S9, SW:RS9_MYCTU (O06259) (151 aa); Fasta score FT E(): 0, 83.2% identity in 155 aa overlap. Previously FT sequenced as SW:RS9_MYCLE (P40828) (153 aa); Fasta score FT E(): 0, 99.3% identity in 153 aa overlap. Contains Pfam FT match to entry PF00380 Ribosomal_S9, Ribosomal protein FT S9/S16. Contains PS00360 Ribosomal protein S9 signature." FT /db_xref="GOA:P40828" FT /db_xref="HSSP:1J5E" FT /db_xref="InterPro:IPR000754" FT /db_xref="UniProtKB/Swiss-Prot:P40828" FT /protein_id="CAC29873.1" FT /translation="MTETSEAVEIAVGTPAAKHSESFVFERSIQTVGRRKEAVVRVRLV FT LGTGKFDLNGRSLEDYFPNKVHQQLIKAPLVTVERTRNFDIFALLHGGGPSGQAGALRL FT GIARALILASPEDRPALKKAGFLTRDPRSTERKKYGLKKARKAPQYSKR" FT misc_feature 113520..113882 FT /note="Pfam match to entry PF00380 Ribosomal_S9, Ribosomal FT protein S9/S16, score 250.20, E-value 3.2e-77" FT misc_feature 113697..113753 FT /note="PS00360 Ribosomal protein S9 signature" FT RBS 113979..113983 FT /note="possible RBS" FT misc_feature 113992..115284 FT /note="Pfam match to entry PF00408 PGM_PMM, FT Phosphoglucomutase/phosphomannomutase, score 339.10, FT E-value 4.8e-98" FT CDS 113992..115383 FT /transl_table=11 FT /gene="mrsA" FT /gene_synonym="ML0366" FT /product="putative phosphoglucomutase/phosphomannomutase" FT /note="Similar to M. tuberculosis mrsA, Rv3441c, FT phosphoglucomutase or phosphomannomutase, TR:O06258 FT (EMBL:AL123456) (448 aa); Fasta score E(): 0, 87.6% FT identity in 445 aa overlap. Similar to many e.g. Salmonella FT typhimurium manB, phosphomannomutase, SW:MANB_SALTY FT (P26341) (264 aa); BlastP Expect 9.5. Previously sequenced FT as TR:Q49869 (EMBL:U00020) (463 aa); Fasta score E(): 0, FT 100.0% identity in 463 aa overlap. Contains Pfam match to FT entry PF00408 PGM_PMM, FT Phosphoglucomutase/phosphomannomutase. Contains PS00710 FT Phosphoglucomutase and phosphomannomutase phosphoserine FT signature." FT /note="Similar to ML0706 and ML0763" FT /db_xref="GOA:Q49869" FT /db_xref="InterPro:IPR006352" FT /db_xref="UniProtKB/Swiss-Prot:Q49869" FT /protein_id="CAC29874.1" FT /translation="MGRLFGTDGVRGVANRELTPELVLALGAAAARCLANSGEPGRRVA FT VIGRDPRASGEMLEAAVIAGLTSAGVDALRVGVLPTPAVAYLTGAYDADFGVMISASHN FT PMVDNGIKIFGPGGHKLDDDTEDQIEDLVTGGPGLRPAGVAIGRVIDAEDATERYLRHV FT GKASTIRLDGLTVVVDCAHGAASSAAPRAYRAAGARVIAINADPNGININDRCGSTDLG FT SLRSAVLAHRADLGLAHDGDADRCLAVDANGDLVDGDAIMVVLALAMQEAGELSSNTLV FT TTVMSNLGLHLAMRSVGVIVRTTDVGDRYVLEELRAGDFSLGGEQSGHIVMPALGSTGD FT GIITGLRLMTRMVQTSSSLAALASAMRALPQVLINVEVADKTTAAAAPLVQTAVETAEV FT ELGNTGRILLRPSGTEPMIRVMVEAAEEDVAHRVATRVAAAVSAQGSPLRCWNPDAISG FT VELRL" FT misc_feature 114277..114321 FT /note="PS00710 Phosphoglucomutase and phosphomannomutase FT phosphoserine signature" FT CDS 115447..115648 FT /pseudo FT /transl_table=11 FT /gene="ML0367" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3440c (Best blastx score 104)" FT CDS 115675..116544 FT /pseudo FT /transl_table=11 FT /gene="ML0368" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3439c (Best blastx score 221)" FT CDS complement(117185..117541) FT /transl_table=11 FT /gene="ML0369" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:Q49877 FT (EMBL:U00020) (118 aa); Fasta score E(): 0, 100.0% identity FT in 118 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q49877" FT /protein_id="CAC29877.1" FT /translation="MSWKSVGRCDAEKRLQYARKHYQIPLIREPRNRVKQTAASHQSPC FT ARACSCCDRGTEDEKVELTSEIAKDRKPIFFYSEKAESVWGEELTAGAAKRDPTLGPPE FT ILLHASLAIGDGDQ" FT CDS complement(117945..118814) FT /transl_table=11 FT /gene="ML0370" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3438, conserved FT hypothetical protein, TR:O06255 (EMBL:AL123456) (280 aa); FT Fasta score E(): 0, 80.6% identity in 279 aa overlap. FT Previously sequenced as TR:Q49872 (EMBL:U00020) (324 aa); FT Fasta score E(): 0, 100.0% identity in 289 aa overlap. FT Contains PS00107 Protein kinases ATP-binding region FT signature." FT /db_xref="InterPro:IPR017441" FT /db_xref="UniProtKB/TrEMBL:Q9CCV6" FT /protein_id="CAC29878.1" FT /translation="MRYRRQVAHTRKLLAALSRRGPHRVLRGDLSFAGLPGVVYTPAGG FT LNLPGVAFGHDWLTGTARYAGLLEHLASWGIVTGAPDTQRGLTPSVLNLAFDLGSALDI FT VAGVRLGPGNISVHPAKLGLVGHGFGGSAAVLAAAGLPGLAGLPAKSAVAIFPTVTSPA FT PEQPAATCKVPGLILTAPGDPKTLNSNALSLYRAWDDATLRIVSKAKAGGLVEGWRMTK FT VVGLAGPHRATQKAVRSLLTGYLLYALGGDKEYRDFADPDMHLPHTVPVDPEAPLVTPE FT QKIVTLLK" FT misc_feature complement(118365..118442) FT /note="PS00107 Protein kinases ATP-binding region FT signature" FT CDS 118979..120856 FT /transl_table=11 FT /gene="glmS" FT /gene_synonym="ML0371" FT /product="putative glucosamine-fructose-6-phosphate FT aminotransferase" FT /EC_number="2.6.1.16" FT /note="Similar to M. tuberculosis glmS, Rv3436c, putative FT glucosamine-fructose-6-phosphate aminotransferase, FT SW:GLMS_MYCTU (O06253) (623 aa); Fasta score E(): 0, 89.3% FT identity in 627 aa overlap. Similar to many e.g. Rhizobium FT leguminosarum nodM, glucosamine--fructose-6-phosphate FT aminotransferase, SW:NODM_RHILV (P08633) (607 aa); Fasta FT score E(): 0, 44.0% identity in 629 aa overlap. Previously FT sequenced as SW:GLMS_MYCLE (P40831) (624 aa); Fasta score FT E(): 0, 99.7% identity in 624 aa overlap. Contains Pfam FT match to entry PF00310 GATase_2, Glutamine FT amidotransferases class-II. Contains 2 Pfam matches to FT entry PF01380 SIS, SIS domain." FT /db_xref="GOA:P40831" FT /db_xref="HSSP:1MOS" FT /db_xref="InterPro:IPR001347" FT /db_xref="UniProtKB/Swiss-Prot:P40831" FT /protein_id="CAC29879.1" FT /translation="MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGN FT LTVRRRAGRLSNLESVLAEMVPASLAGNVGLGHIRWATHGRPTDRNAHPHRDATGKIAV FT VHNGIIENFPSLRHELEIAGVEFVSDTDTEVAVHLVAQAYCAGETAGDFVGSVLAVLRR FT LQGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMFVGSDVAAFIEHTRQAVELGQDQ FT AVVITADGYRISDFDGNDDAVNARTFHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTL FT LGHFTGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYTIEHWTRLPVEVELA FT SEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDA FT VLYTRAGPEIGVASTKTFLAQVAANYLLGLALAQARGTKYPDEVQREYRELEAMPDLVA FT RVIAGMGPVADLAYRFAQSTTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKH FT GPIALIEENLPVIVVMPSPKGSAMLHAKLLSNIREIQTRGAVTIVIAEEGDDTVRLYAD FT HLIELPAVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE" FT misc_feature 118982..119557 FT /note="Pfam match to entry PF00310 GATase_2, Glutamine FT amidotransferases class-II, score 213.60, E-value 3e-72" FT misc_feature 119873..120277 FT /note="Pfam match to entry PF01380 SIS, SIS domain, score FT 183.00, E-value 4.8e-51" FT misc_feature 120389..120811 FT /note="Pfam match to entry PF01380 SIS, SIS domain, score FT 148.10, E-value 1.5e-40" FT CDS complement(120951..121073) FT /pseudo FT /transl_table=11 FT /gene="ML0372" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0893c (Best blastx score 92)" FT CDS 121202..122623 FT /transl_table=11 FT /gene="ML0373" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3433c, conserved FT hypothetical protein, SW:YY33_MYCTU (O06250) (473 aa); FT Fasta score E(): 0, 84.6% identity in 473 aa overlap. FT Similar to many bacterial hypothetical proteins. Previuosly FT sequenced as SW:YY33_MYCLE (P37391) (392 aa); Fasta score FT E(): 0, 94.5% identity in 381 aa overlap. Contains Pfam FT match to entry PF01256 UPF0031, Uncharacterized protein FT family UPF0031. Contains PS01049 Uncharacterized protein FT family UPF0031 signature 1. Contains PS01050 FT Uncharacterized protein family UPF0031 signature 2." FT /db_xref="HSSP:1KYH" FT /db_xref="InterPro:IPR004443" FT /db_xref="UniProtKB/Swiss-Prot:P37391" FT /protein_id="CAC29881.1" FT /translation="MRHYYSVAAIRDAEASLLASLPDGVLMKRAAYGLASVIIRELAVR FT TGGVTGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRVHRKALVAFRKAGG FT RIVENVSAATDLVIDGVVGISGSGPLRPAAAAVFATVSASGVPVVAVDLPSGIDVVTGV FT INGPAVHAALTVTFGGLKPVHALADCGDVTLVDIGLDLPDSDILGLQAADVAAYWPVPG FT VHDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGSAYTQVLAHWPEVIAS FT ATPTAAGRVQSWVVGPGLGIDATATAALWFALETDLPVLVDADGLTMLAAHPDLVINRN FT APTVLTPHASEFARLAGTPPGDDRVGACRKLADSFGATVLLKGNVTVIADPGGPVYLNP FT AGQSWAATAGSGDVLSGMIGALLAAGLPAAEAAAAAAFVHARAAALSAADPGPGDVPTS FT ASRMVSHIRTALAAL" FT misc_feature 121898..122596 FT /note="Pfam match to entry PF01256 UPF0031, Uncharacterized FT protein family UPF0031, score 319.30, E-value 4.6e-92" FT misc_feature 122075..122107 FT /note="PS01049 Uncharacterized protein family UPF0031 FT signature 1" FT misc_feature 122423..122455 FT /note="PS01050 Uncharacterized protein family UPF0031 FT signature 2" FT CDS 122653..124022 FT /pseudo FT /transl_table=11 FT /gene="gadB" FT /gene_synonym="ML0374" FT /product="glutamate decarboxylase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT gadB (Best blastx score 527)" FT RBS 124117..124121 FT /note="possible RBS" FT CDS 124132..125298 FT /transl_table=11 FT /gene="alr" FT /gene_synonym="ML0375" FT /product="putative alanine racemase" FT /EC_number="5.1.1.1" FT /note="Similar to M. tuberculosis alr, Rv3423c, putative FT alanine racemase, SW:ALR_MYCTU (Q50705) (384 aa); Fasta FT score E(): 0, 84.6% identity in 382 aa overlap. Similar to FT many e.g. Mycobacterium smegmatis alr, alanine racemase, FT SW:ALR_MYCSM (P94967) (389 aa); Fasta score E(): 0, 67.2% FT identity in 378 aa overlap. Previously sequenced as FT SW:ALR_MYCLE (P38056) (388 aa); Fasta score E(): 0, 99.7% FT identity in 388 aa overlap. Contains 2 Pfam matches to FT entry PF00842 Ala_racemase, Alanine racemase." FT /db_xref="GOA:P38056" FT /db_xref="HSSP:1BD0" FT /db_xref="InterPro:IPR000821" FT /db_xref="UniProtKB/Swiss-Prot:P38056" FT /protein_id="CAC29883.1" FT /translation="MAVTPISLRPGVLAEAVVDLGAIDYNVRVLREHAGMAQLMVVLKA FT DAYGHGATQVALAALAAGAAELGVATVDEALALRADGISAPVLAWLHPPGIDFGPALLA FT DVQIAVSSVRQLDELLDAVRRTGRTATVTVKADTGLNRNGVVTDQYPAMLTALQRAVVE FT DAVRLRGLMSHLVYADQPDNPSNDVQGKRFAALLAQAHEQGLRFEVAHLSNSSATMSRP FT DLAYDLVRPGIAVYGLSPVPSRGDMGLIPAMTVKCAVAMVKSIRAGEGVSYGHDWIAQH FT DTNLALLPVGYADGVFRSLGGRLDVLINGKRRPGVGRICMDQFVVDLGPGPIDVAEGDE FT AILFGPGARGEPTAQDWADLLGTIHYEVVTSLRGRITRTYREAQTVDR" FT misc_feature 124243..124395 FT /note="Pfam match to entry PF00842 Ala_racemase, Alanine FT racemase, score 72.80, E-value 5.6e-19" FT misc_feature 124534..125274 FT /note="Pfam match to entry PF00842 Ala_racemase, Alanine FT racemase, score 245.40, E-value 8.1e-70" FT CDS 125288..126289 FT /transl_table=11 FT /gene="ML0376" FT /product="putative membrane protein" FT /note="Unknown function. Contains hydrophobic, possible FT membrane-spanning region near the N-terminus." FT /db_xref="UniProtKB/TrEMBL:Q9CCV4" FT /protein_id="CAC29884.1" FT /translation="MTDDEIRRRRNGRPWLAGGTGLVPVATIVGALSLRSIFERDNACR FT DPYVDRDFEKLGDERRCWVTISGGMALVVREEGAVKAPVAMVFAYGFYLRMDSFHFQRK FT RFGKRWGPQVRMVFYDHCGHVQSSEVALDTYTLTQLGQDLRTVLQTVTPHGMIVLVGHS FT MEGILKSPALEAVRLTSRSASKLMHRGSIASQSLIGPILRAASYSDLRVSRGLDAFSQR FT IMNDTLIAILVSFLHALELHEETAGLWPLLRVPALIACGDHDLLTSDERSRGMAAVLPL FT LALVIVSGASRLALLDKPGAINDGLVRLVNRAVPGKAALRYRRFKERLQRHG" FT RBS 126263..126267 FT /note="possible RBS" FT CDS 126282..126767 FT /transl_table=11 FT /gene="ML0377" FT /note="Similar to M. tuberculosis Rv3422c, conserved FT hypothetical protein, SW:YY22_MYCTU (Q50706) (168 aa); FT Fasta score E(): 0, 77.4% identity in 146 aa overlap. FT Similar to many other bacterial hypothetical proteins. FT Previously sequenced as SW:YY22_MYCLE (Q49864) (161 aa); FT Fasta score E(): 0, 100.0% identity in 161 aa overlap. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:Q49864" FT /db_xref="HSSP:1FL9" FT /db_xref="InterPro:IPR003442" FT /db_xref="UniProtKB/Swiss-Prot:Q49864" FT /protein_id="CAC29885.1" FT /translation="MAEYSLRSGAVICERVEDTVALGSRLGEQLRAGDVVVLSGPLGAG FT KTVLAKGIAVAMDVDGPVISPTYVLARVHLPRRLGTPAMIHVDVYRLLDHRDADLVGEL FT DSLDLDTDLAEAVVVMEWGAGLAECLAARHLDIRLERVRYSDVRIATWQWVCSRDRP" FT misc_feature 126399..126422 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 126764..127843 FT /transl_table=11 FT /gene="ML0378" FT /product="putative acetyltransferase" FT /note="Similar to M. tuberculosis rimI, Rv3420c, putative FT ribosomal protein S18 acetyltransferase, TR:Q50708 FT (EMBL:Z77165) (158 aa); Fasta score E(): 0, 72.1% identity FT in 154 aa overlap in the C-terminus and to M. tuberculosis FT Rv3421c hypothetical protein, SW:YY21_MYCTU (Q50707) (211 FT aa); Fasta score E(): 0, 75.6% identity in 205 aa overlap FT in the N-terminus. Appears to be a fusion of two M. FT tuberculosis homologues. Similar to many hypothetical FT acetyltransferases. Previously sequenced as SW:YY21_MYCLE FT (Q49857) (359 aa); Fasta score E(): 0, 100.0% identity in FT 359 aa overlap. Contains Pfam match to entry PF00583 FT Acetyltransf, Acetyltransferase (GNAT) family." FT /db_xref="GOA:Q49857" FT /db_xref="InterPro:IPR006464" FT /db_xref="UniProtKB/Swiss-Prot:Q49857" FT /protein_id="CAC29886.1" FT /translation="MSIVLAIDTATAAVTAGIVAFDGHDCFTLAERVTVDAKAHVERLT FT PNVLVALADAELAMCELDAVVVGCGPGPFTGLRVGMATAAAYGHALGIPVHGVCSLDAI FT GVRTTGDTLVVTDARRHEVYWARYRDGVRIAGPAVGSPTDVDPGTALTVAGSPEHAALF FT GLPLCEPIYPTPAGLVAAVPDWSVSPIPLVALYLRRPDAKPITADNEPIVIGTLTPADV FT DRCAQLESQFFDGDNPWPAAAFDRELANSYNCYVGARTADTLVGYAGITRLGHTPPFEY FT EVHTIAVDPAYRGRGVGRRLLGELLDFAGSGAIYLEVRTDNETAIALYRSVGFERIGLR FT PRYYPASGADAYLMRREAQ" FT misc_feature 127403..127768 FT /note="Pfam match to entry PF00583 Acetyltransf, FT Acetyltransferase (GNAT) family, score 69.60, E-value FT 6.8e-17" FT RBS 127831..127835 FT /note="possible RBS" FT CDS 127840..128895 FT /transl_table=11 FT /gene="gcp" FT /gene_synonym="ML0379" FT /product="putative O-sialoglycoprotein endopeptidase" FT /EC_number="3.4.24.57" FT /note="Similar to M. tuberculosis gcp, putative FT O-sialoglycoprotein endopeptidase, SW:GCP_MYCTU (Q50709) FT (344 aa); Fasta score E(): 0, 86.1% identity in 345 aa FT overlap. Similar to many e.g. Pasteurella haemolytica gcp, FT O-sialoglycoprotein endopeptidase, SW:GCP_PASHA (P36175) FT (325 aa); Fasta score E(): 0, 45.8% identity in 319 aa FT overlap. previously sequenced as SW:GCP_MYCLE (P37969) (351 FT aa); Fasta score E(): 0, 100.0% identity in 351 aa overlap. FT Contains Pfam match to entry PF00814 Peptidase_M22, FT Glycoprotease family. Contains PS01016 Glycoprotease family FT signature." FT /db_xref="GOA:P37969" FT /db_xref="InterPro:IPR017861" FT /db_xref="UniProtKB/Swiss-Prot:P37969" FT /protein_id="CAC29887.1" FT /translation="MTISAVPGTIILAIETSCDETGVGIACLDDYGTVTLLADEVASSV FT DEQARFGGVVPEIASRAHLEALGPTIRCALAAAGLTGSAKPDVVAATIGPGLAGALLVG FT VAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLQVRSLGAP FT IVELGSTVDDAAGEAYDKVARLLGLGYPGGKVLDDLARTGDRDAIVFPRGMTGPADDLN FT AFSFSGLKTAVARYVESHPDALPADVAAGFQEAVADVLTMKAVRAATGLGVSTLLIVGG FT VAANSRLRELAAQRCAAAGLMLRIPGPRFCTDNGAMIAAFAAHLLAAAAPPSPLDVPSD FT PGLPVVKRQIN" FT misc_feature 127864..128820 FT /note="Pfam match to entry PF00814 Peptidase_M22, FT Glycoprotease family, score 601.80, E-value 4e-177" FT misc_feature 128164..128226 FT /note="PS01016 Glycoprotease family signature" FT RBS 129163..129167 FT /note="possible RBS" FT CDS 129177..129479 FT /transl_table=11 FT /gene="groES" FT /gene_synonym="ML0380" FT /product="10 kD chaperonin" FT /note="Similar to M. tuberculosis groES, 10 kD chaperonin, FT SW:CH10_MYCTU (P09621) (99 aa); Fasta score E(): 3.6e-32, FT 89.9% identity in 99 aa overlap. Previously sequenced as FT SW:CH10_MYCLE (P24301) (99 aa); Fasta score E(): 0, 100.0% FT identity in 99 aa overlap. Contains Pfam match to entry FT PF00166 cpn10, Chaperonins 10 Kd subunit. Contains PS00681 FT Chaperonins cpn10 signature." FT /db_xref="GOA:P24301" FT /db_xref="InterPro:IPR018369" FT /db_xref="PDB:1LEP" FT /db_xref="UniProtKB/Swiss-Prot:P24301" FT /protein_id="CAC29888.1" FT /translation="MAKVKIKPLEDKILVQAGEAETMTPSGLVIPENAKEKPQEGTVVA FT VGPGRWDEDGAKRIPVDVSEGDIVIYSKYGGTEIKYNGEEYLILSARDVLAVVSK" FT misc_feature 129186..129473 FT /note="Pfam match to entry PF00166 cpn10, Chaperonins 10 Kd FT subunit, score 180.70, E-value 2.4e-50" FT misc_feature 129192..129266 FT /note="PS00681 Chaperonins cpn10 signature" FT RBS 129547..129553 FT /note="possible RBS" FT CDS 129558..131171 FT /transl_table=11 FT /gene="groEL1" FT /gene_synonym="ML0381" FT /product="60 kDa chaperonin 1" FT /note="Similar to M. tuberculosis groEL1, 60 kDa chaperonin FT 1, SW:CH61_MYCTU (Q59573) (539 aa); Fasta score E(): 0, FT 82.9% identity in 539 aa overlap. Previously sequenced as FT SW:CH61_MYCLE (P37578) (537 aa); Fasta score E(): 0, 100.0% FT identity in 537 aa overlap. Contains Pfam match to entry FT PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family. Contains FT PS00296 Chaperonins cpn60 signature." FT /db_xref="GOA:P37578" FT /db_xref="HSSP:1IOK" FT /db_xref="InterPro:IPR002423" FT /db_xref="UniProtKB/Swiss-Prot:P37578" FT /protein_id="CAC29889.1" FT /translation="MSKLIEYDETARHAMEVGMNKLADTVRVTLGPRGRHVVLAKAFGG FT PTITNDGVTVAREIDLEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVKGGLR FT MVAAGANPVALGAGISKAADAVSEALLAVATPVAGKDAITQVATVSSRDEQIGALVGEG FT MNKVGTDGVVSVEESSTLDTELEFTEGVGFDKGFLSAYFVTDFDSQQAVLDDPLVLLHQ FT EKISSLPELLPMLEKVTESGKPLLIVAEDLEGEALATLVVNSIRKTLKAVAVKSPFFGD FT RRKAFLEDLAIVTGGQVVNPETGLVLREVGTDVLGSARRVVVSKDDTIIVDGGGSNDAV FT AKRVNQLRAEIEVSDSEWDREKLQERVAKLAGGVAVIKVGAVTETALKKRKESVEDAVA FT AAKASIEEGIIAGGGSALVQCGAALKQLRTSLTGDEALGIDVFFEALKAPLYWIATNAG FT LDGAVVVDKVSGLPAGHGLNASTLGYGDLVADGVVDPVKVTRSAVLNAASVARMMLTTE FT TAVVDKPAKTEEHDHHGHAH" FT misc_feature 129621..131129 FT /note="Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 FT chaperonin family, score 825.30, E-value 2.2e-244" FT misc_feature 130764..130799 FT /note="PS00296 Chaperonins cpn60 signature" FT CDS complement(131771..132079) FT /transl_table=11 FT /gene="whiB3" FT /gene_synonym="ML0382" FT /product="putative transcriptional regulator" FT /note="Similar to M. tuberculosis whiB3, Rv3416, putative FT regulatory protein, TR:Q50710 (EMBL:AL123456) (102 aa); FT Fasta score E(): 0, 86.3% identity in 102 aa overlap. FT Similar to many e.g. Streptomyces coelicolor whiD, FT developmental regulatory gene, TR:O88103 (EMBL:AJ010601) FT (112 aa); Fasta score E(): 1.1e-24, 61.8% identity in 102 FT aa overlap. Previously sequenced as TR:Q49871 (EMBL:U00015) FT (102 aa); Fasta score E(): 0, 100.0% identity in 102 aa FT overlap." FT /note="Similar to ML0760, ML0804 and ML2307" FT /db_xref="InterPro:IPR003482" FT /db_xref="UniProtKB/TrEMBL:Q49871" FT /protein_id="CAC29890.1" FT /translation="MPQPKQLPGPNATIWNWQLQGLCRGVDSSMFFHPDGERGRARMQR FT EQRAKEMCRRCPVIEECRAHALDVGEPYGVWGGLSESERDLLLKGDLARSRSIPRSA" FT RBS complement(132089..132093) FT /note="possible RBS" FT CDS 132440..133285 FT /transl_table=11 FT /gene="ML0383" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3415c, conserved FT hypothetical protein, TR:Q50711 (EMBL:AL123456) (275 aa); FT Fasta score E(): 0, 73.6% identity in 277 aa overlap. FT Previously sequenced as TR:Q49858 (EMBL:U00020) (264 aa); FT Fasta score E(): 0, 99.6% identity in 263 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCV3" FT /protein_id="CAC29891.1" FT /translation="MTSVSIVVEIGHTSAAEPMLAAAAFGNQPGRWPLPTATTPHQLWL FT RAVAAGGQGHYSSAYRDLAVLRRSVPAGRLASLAHSTHGSFLRQLGWHSLARGWDGRAL FT VLAGTDSEARADALIGLAADALGVGRLAAAATLLRRVGSALAPAQLPAQVADRLAVRRR FT WVAAELAMAVGDGATAVRHAREAVELAQVGRVVSVRHQVKSDVVLAAALCSAATERARV FT VAEAALAATGRLGLIPLRWALACLLIDIGSVTFSEPELSELRDVCADQVRRAGGTWRTA FT " FT CDS 133371..133955 FT /pseudo FT /transl_table=11 FT /gene="sigD" FT /gene_synonym="ML0384" FT /product="ECF subfamily sigma subunit (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT sigD (Best blastx score 312)" FT CDS 133951..134698 FT /pseudo FT /transl_table=11 FT /gene="ML0385" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3413c (Best blastx score 318)" FT CDS complement(136093..136506) FT /transl_table=11 FT /gene="ML0386" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3412, conserved FT hypothetical protein, SW:YY12_MYCTU (Q50714) (136 aa); FT Fasta score E(): 0, 93.4% identity in 136 aa overlap. FT Previously sequenced as SW:YY12_MYCLE (Q49742) (137 aa); FT Fasta score E(): 0, 99.3% identity in 137 aa overlap." FT /db_xref="UniProtKB/Swiss-Prot:Q49742" FT /protein_id="CAC29894.1" FT /translation="MRDHLPPGLPPDPFADDPCDPSAALDAVEPGQPLDQQERIAVEAD FT LADLAVYEALLAHKGIRGLVVCCDECQQDHYHDWDMLRANLLQLLIDGTVRPHEPAYDP FT EPDSYVTWDYCRGYADASLNQATSDADGYRRRH" FT RBS 136647..136651 FT /note="possible RBS" FT CDS 136661..138250 FT /transl_table=11 FT /gene="guaB2" FT /gene_synonym="ML0387" FT /product="putative inosine-5'-monophosphate dehydrogenase" FT /EC_number="1.1.1.205" FT /note="Similar to M. tuberculosis guaB2, Rv3411c, putative FT inosine-5'-monophosphate dehydrogenase, SW:IMDH_MYCTU FT (Q50715) (529 aa); Fasta score E(): 0, 92.4% identity in FT 529 aa overlap. Similar to many e.g. Escherichia coli guaB, FT inosine-5'-monophosphate dehydrogenase, SW:IMDH_ECOLI FT (P06981) (488 aa); Fasta score E(): 0, 54.3% identity in FT 490 aa overlap. Previously sequenced as SW:IMDH_MYCLE FT (Q49729) (529 aa); Fasta score E(): 0, 100.0% identity in FT 529 aa overlap. Contains 2 Pfam matches to entry PF00571 FT CBS, CBS domain. Contains Pfam match to entry PF00478 FT IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. FT Contains Pfam match to entry PF01574 IMPDH_N, IMP FT dehydrogenase / GMP reductase N terminus." FT /note="Similar to ML2066 and shows weaker similarity to FT ML0388" FT /db_xref="GOA:Q49729" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR018529" FT /db_xref="UniProtKB/Swiss-Prot:Q49729" FT /protein_id="CAC29895.1" FT /translation="MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGL FT TFDDVLLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAMARAGGMG FT VLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVVDDS FT GALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPVVD FT GHGRLTGLITVKDFVKTEQHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLI FT VDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGST FT CTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSL FT LAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPE FT GIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDV FT AMTVEAPNYYPR" FT misc_feature 136772..137035 FT /note="Pfam match to entry PF01574 IMPDH_N, IMP FT dehydrogenase / GMP reductase N terminus, score 193.40, FT E-value 3.5e-54" FT misc_feature 137039..137200 FT /note="Pfam match to entry PF00571 CBS, CBS domain, score FT 43.40, E-value 5.1e-09" FT misc_feature 137222..137383 FT /note="Pfam match to entry PF00571 CBS, CBS domain, score FT 40.90, E-value 2.9e-08" FT misc_feature 137471..138160 FT /note="Pfam match to entry PF00478 IMPDH_C, IMP FT dehydrogenase / GMP reductase C terminus, score 348.80, FT E-value 5.9e-101" FT CDS 138274..139386 FT /transl_table=11 FT /gene="guaB3" FT /gene_synonym="ML0388" FT /product="putative inosine-5'-monophosphate dehydrogenase" FT /note="Similar to M. tuberculosis guaB3, Rv3410c, putative FT inosine-5'-monophosphate dehydrogenase, SW:YY10_MYCTU FT (Q50716) (375 aa); Fasta score E(): 0, 90.5% identity in FT 368 aa overlap. This ORF is similar in part to ML0387 and FT ML2066, which more closely resemble the experimentally FT characterised IMP-DH's (e.g. from Escherichia coli). This FT shorter homologue is conserved in several bacterial genera. FT Previously sequenced as SW:YY10_MYCLE (U00015) (375 aa); FT Fasta score E(): 0, 100.0% identity in 370 aa overlap. FT Contains Pfam match to entry PF00478 IMPDH_C, IMP FT dehydrogenase / GMP reductase C terminus." FT /note="Shows weak similarity to ML0387 and ML2066" FT /db_xref="GOA:Q49721" FT /db_xref="HSSP:1B3O" FT /db_xref="InterPro:IPR005992" FT /db_xref="UniProtKB/Swiss-Prot:Q49721" FT /protein_id="CAC29896.1" FT /translation="MGRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVA FT HPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHADVGAKVAQLIEAAEKEPEPATAVCL FT LQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQNAQVLTPVLLAAGIDLLVVQGSIV FT SAECVASGGEPLNLKTFISELDVPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTRGATT FT SDEVLGISVPMATAIADAAAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAV FT VLGTPLAQSAEALGGGWFWPAAAAHPSLPRGALLQTAVGERPSLQQVLNGPSDNPFGTL FT NLVGGLRRSMAKAGYCDLKEFQKVGLIVSI" FT misc_feature 138712..139368 FT /note="Pfam match to entry PF00478 IMPDH_C, IMP FT dehydrogenase / GMP reductase C terminus, score -16.40, FT E-value 3.7e-06" FT CDS 139451..141160 FT /transl_table=11 FT /gene="choD" FT /gene_synonym="ML0389" FT /product="putative cholesterol oxidase" FT /note="Similar to M. tuberculosis choD, Rv3409c, putative FT cholesterol oxidase, TR:Q57307 (EMBL:Al123456) (578 aa); FT Fasta score E(): 0, 88.6% identity in 569 aa overlap. FT Similar to Streptomyces sp. (strain SA-COO) choA, FT cholesterol oxidase precursor, SW:CHOD_STRSQ (P12676) (546 FT aa); Fasta score E(): 0.013, 26.6% identity in 561 aa FT overlap. Previously sequenced as TR:Q59530 (EMBL:U00015) FT (585 aa); Fasta score E(): 0, 100.0% identity in 569 aa FT overlap." FT /db_xref="GOA:Q9CCV1" FT /db_xref="HSSP:3COX" FT /db_xref="InterPro:IPR006076" FT /db_xref="UniProtKB/TrEMBL:Q9CCV1" FT /protein_id="CAC29897.1" FT /translation="MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRRFADEDFA FT KTSWDLRKFLWAPKLGCYGIQRIHLLRNVMILAGAGVGGGSLNYANTLYVPPEPFFANQ FT QWAHITDWHSELAPHYDQAQRMLGVVCNPTFTDADRILKEVVDEMGFGDTFVPTPVGVF FT FGPDGTQTPGRTVADPYFGGVGPVRTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGA FT QVIPMTTVKGFELRSEGLWEVHTVRTGSWLRRGRRTFTAAHLLLAAGTWGTQRLLFRMR FT DQGKLPRLSQRLGVLTRTNSESIVGAGTLNVMPDRDLTHGVAITSSIHPTSDTHIEPIR FT YGKGSNAMGLLQTLMTDGPGPEGTDVPRWRQLLHQASEDPRRMLRLINPRRWSERTVIA FT LVMQHLDNSITTFTKRGKLGIRWYSSKQGNGEPNPSWIPIGNEVTRRLAAKIDGVAGGT FT WGELFNIPLTAHFLGGAVIGDNAEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLS FT IAAQAERAASLWPNKGQHDQRPRQGESYRRLAPIAPDHPVVPAEALGALRWL" FT CDS complement(141208..141600) FT /pseudo FT /transl_table=11 FT /gene="ML0390" FT /product="possibe dioxygenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3406 (Best blastx score 382)" FT CDS 141789..142124 FT /pseudo FT /transl_table=11 FT /gene="ML0391" FT /product="putative transcriptional regulator (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3405c (Best blastx score 162)" FT CDS complement(142263..144641) FT /transl_table=11 FT /gene="ML0392" FT /product="putative sugar phosphorylase" FT /note="Similar to M. tuberculosis Rv3401, conserved FT hypothetical protein, SW:YY01_MYCTU (Q50724) (786 aa); FT Fasta score E(): 0, 91.4% identity in 782 aa overlap. Shows FT weak similarity to Lactobacillus sanfranciscensis mapA, FT maltose phosphorylase, TR:O87772 (EMBL:AJ224340) (753 aa); FT Fasta score E(): 1.4e-13, 29.0% identity in 769 aa overlap. FT Similar to many bacterial hypothetical proteins e.g. FT Streptomyces coelicolor SCF42.31C, putative glycosyl FT transferase, TR:CAB69693 (EMBL:AL137165) (792 aa); Fasta FT score E(): 0, 58.9% identity in 790 aa overlap. Previously FT sequenced as SW:YY01_MYCLE (Q49736) (792 aa); Fasta score FT E(): 0, 100.0% identity in 792 aa overlap. Contains a FT probable helix-turn-helix motif at aa 515-536 (Score 1032, FT SD +2.70)" FT /db_xref="GOA:Q49736" FT /db_xref="InterPro:IPR017045" FT /db_xref="UniProtKB/Swiss-Prot:Q49736" FT /protein_id="CAC29900.1" FT /translation="MITEEAFPVEPWQIRETRLDLNLLAQSESLFALSNGHIGLRGNLD FT EGEPYGLPGTYLNSFYEIRPLPYAEAGYGYPEAGQTVVDVTNGKILRLFVEDEPFDVRY FT GEVIFHERVLDLCAGTLTRRANWRSPADKQVKVVSTRLVSLAHRSVAAIEYVVEALDKF FT VRVTVQSELVSNEDQPETSGDPRVSAILDNPLEAVEHEATERGGLLMHRTRASSLMMAA FT GMDHEVEVPGRVEITTDARPDLARTTVICGLRPGQKLRIVKYLAYGWSSLRSRPALHDQ FT ATAALHTARYSGWQGLLDAQRAYLNEFWDSADVEVEGDPESQQAVRFGLFHLLQASARA FT ERRAIPSKGLTGTGYDGHAFWDTEGFVLPVLTYTAPHAVADALRWRASTLQLAKDRAAE FT LGLDGASFCWRTIRGQECSAYWPAGTAAWHINADIAMAFERYRIVTGDHSLEEECGLAV FT LIETARLWLSLGHHDRHGVWHLDGVTGPDEYTAVVRDNVFTNLMAASNLITAADACLRQ FT PEAAKAMGVTTEEMAAWRDAADAANIPYDDELGVHQQCEGFTTFAEWDFEANTTYPLFL FT HEAYVRLYPAQVIKQADLVLAMQWQSHAFTPEQKARNVDYYERRMVRDSSLSACTQAVM FT CAEVGHLELAHDYAYEAALIDLRDLHRNTRDGLHMASLAGAWTALVGGFGGLRDDEGIL FT SIDPQLPHGISRLRFRLRWRGFRLTVDARHADVTYTLRDGPGGELTIRHAGEHLTLKSD FT SPSTIAVRDRKPLLPPPSQPPGREPVSRRHKSLIISAAR" FT CDS complement(144655..145440) FT /transl_table=11 FT /gene="ML0393" FT /product="putative hydrolase" FT /note="Similar to M. tuberculosis Rv3400, hypothetical FT protein, SW:YY00_MYCTU (Q50725) (262 aa); Fasta score E(): FT 0, 74.4% identity in 262 aa overlap. Previously sequenced FT as SW:YY00_MYCLE (Q49741) (261 aa); Fasta score E(): 0, FT 100.0% identity in 261 aa overlap. Contains Pfam match to FT entry PF00702 Hydrolase, haloacid dehalogenase-like FT hydrolase." FT /db_xref="GOA:Q49741" FT /db_xref="HSSP:1O08" FT /db_xref="InterPro:IPR005834" FT /db_xref="UniProtKB/Swiss-Prot:Q49741" FT /protein_id="CAC29901.1" FT /translation="MANWDHPTSKVRSTVLGLPEQVRACLFDLDGVLTDTASVHAKAWQ FT TMFDTYLYQRAKHTGENFVPFDPTADYRQYVDGKKREDGVRSFLGSRGITLPEGSADNS FT GDVETIYGLGNRKDDLFRQVLKEHGIEVFDGSRRYLEAITYAGLGVAVVSSSTNTRDVL FT KITGLDRFVQQQVDGITLREEHIAGKPAPDSYLRGAQLLDVAPDAAAVFEDALSGVQAG FT LSGHFGFVVGINRTGRVDQAEELRRIGANVVVTDLAELL" FT misc_feature complement(144733..145377) FT /note="Pfam match to entry PF00702 Hydrolase, haloacid FT dehalogenase-like hydrolase, score 145.80, E-value 7.9e-40" FT CDS complement(145915..146427) FT /transl_table=11 FT /gene="ML0394" FT /product="hypothetical protein" FT /note="Unknown function. Possible CDS suggested by GC FT frameplot and codon usage plots." FT /db_xref="UniProtKB/TrEMBL:Q9CCV0" FT /protein_id="CAC29902.1" FT /translation="MRLRLVGCAKTSHTMGRIATSQLMYLIEITSETKALDGGSAIGGT FT SRFAADQRRCRVTAVDLTREYYDTARWLNQLVSLVKQIFVQQSDVTKLPFVDATFQVIF FT SQHVHLSMANNAHLILRITPGIDLRELTCHVEHHHIKKRLTLLSGAMARRAQPQPSRHL FT QPVTSHH" FT RBS complement(146440..146445) FT /note="possible RBS" FT CDS 147043..148632 FT /transl_table=11 FT /gene="guaA" FT /gene_synonym="ML0395" FT /product="putative GMP synthase" FT /EC_number="6.3.5.2" FT /note="Similar to M. tuberculosis guaA, Rv3396c, putative FT GMP synthase, SW:GUAA_MYCTU (Q50729) (525 aa); Fasta score FT E(): 0, 86.9% identity in 525 aa overlap. Similar to many FT e.g. Bacillus subtilis guaA, GMP synthase FT [glutamine-hydrolyzing], SW:GUAA_BACSU (P29727) (513 aa); FT Fasta score E(): 0, 50.7% identity in 515 aa overlap. FT Previously sequenced as SW:GUAA_MYCLE (P46810) (590 aa); FT Fasta score E(): 0, 100.0% identity in 529 aa overlap. FT Contains Pfam match to entry PF00958 GMP_synt_C, GMP FT synthase C terminal domain. Contains Pfam match to entry FT PF00117 GATase, Glutamine amidotransferase class-I. FT Contains PS00442 Glutamine amidotransferases class-I active FT site." FT /db_xref="GOA:P46810" FT /db_xref="HSSP:1GPM" FT /db_xref="InterPro:IPR018318" FT /db_xref="UniProtKB/Swiss-Prot:P46810" FT /protein_id="CAC29903.1" FT /translation="MADSAGLDQPEPSPRPVLVVDFGAQYAQLIARRVREARVFSEVIP FT HTTSIEEITARDPLAIVLSGGPASVYTEGAPQLDPALFDLGLPVFGICYGFQAMAQVLG FT GTVARTKTSEYGRTELKVLGGDLHSGLPGVQPVWMSHGDAVTAAPDGFDVAASSSGAPV FT AAFENRDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLDADWTAANIAGVLVEQVRAQ FT IGNGHAICGLSGGVDSAVAAALVQRAIGDRLTCIFVDHGLLRDGERGQVQRDFVAATGA FT KLVTVDAAETFLQALSGVTNPEGKRKIIGRQFIRAFEGAVRDLLGDSTFDSGIEFLVQG FT TLYPDVVESGGGSGTANIKSHHNVGGLPDNLRFKLVEPLRLLFKDEVRAVGRQLDLPEE FT IVARQPFPGPGLGIRIVGEVTAERLDTLRRADSIAREELTTAGLDYQIWQCPVVLLADV FT RSVGVQGDNRSYGHPIVLRPVSSEDAMTADWTWVPYEVLECISTRITNEVAEVNRVVLD FT ITNKPPGTIEWE" FT misc_feature 147094..147639 FT /note="Pfam match to entry PF00117 GATase, Glutamine FT amidotransferase class-I, score 195.90, E-value 6.5e-55" FT misc_feature 147304..147339 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT misc_feature 148318..148629 FT /note="Pfam match to entry PF00958 GMP_synt_C, GMP synthase FT C terminal domain, score 209.80, E-value 4.1e-59" FT repeat_region complement(148656..149841) FT /note="1186 bp repeat, 100% identical to region FT 3241403..3242588" FT CDS complement(148714..149823) FT /transl_table=11 FT /gene="ML0396" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0046c, conserved FT hypothetical protein, TR:P71703 (EMBL:AL123456) (367 aa); FT Fasta score E(): 0, 91.8% identity in 366 aa overlap. FT Similar to other bacterial hypothetical proteins. FT C-terminal half show weak similarity to eukaryotic FT myo-inositol-1-phosphate synthases e.g. Candida albicans FT ino1, myo-inositol-1-phosphate synthase, SW:INO1_CANAL FT (P42800) (520 aa); Fasta score E(): 0.22, 24.4% identity in FT 242 aa overlap. Previously sequenced as TR:Q57240 FT (EMBL:U00015) (369 aa); Fasta score E(): 0, 100.0% identity FT in 369 aa overlap. Contains Pfam match to entry PF01658 FT Inos-1-P_synth, Myo-inositol-1-phosphate synthase." FT /note="Identical in sequence to ML2692" FT /db_xref="GOA:Q57240" FT /db_xref="HSSP:1GR0" FT /db_xref="InterPro:IPR002587" FT /db_xref="UniProtKB/Swiss-Prot:Q57240" FT /protein_id="CAC29904.1" FT /translation="MSEHNPAGAPGASTEVRVAIVGVGNCASSLVQGIEYYQNADDTST FT VPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGVDLSDAIFTSENNTIKIADVPPTNVVVQ FT RGPTLDGIGKYYTDTIELSDVPPVDVVQALTEAKTDVLVSYLPVGSEEADKFYAQCAIN FT ARVAFVNALPVFIASDPVWAKKFADARVPIVGDDIKSQVGATITHRVMAKLFEDRGVQL FT DRTMQLNVGGNMDFLNMLERERVQSKKISKTQAVTSNVHREFNTKDIHIGPSDHVGWLD FT DRKWAYVRLEGRGFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPA FT SSYLMKSPPQQLPDEIARAQLEEFIIDTK" FT misc_feature complement(148723..149781) FT /note="Pfam match to entry PF01658 Inos-1-P_synth, FT Myo-inositol-1-phosphate synthase, score 558.20, E-value FT 5.3e-164" FT CDS complement(149939..151747) FT /transl_table=11 FT /gene="ML0397" FT /product="putative transporter protein" FT /note="C-terminal half is similar to sugar permeases e.g. FT Escherichia coli AraH, L-arabinose transport system FT permease protein, SW:ARAH_ECOLI (P08532) (329 aa); Fasta FT score E(): 1.1e-26, 36.0% identity in 297 aa overlap. The FT N-terminal half shows weak similarity to other proteins FT containing PAS and DUF9 domains. There is a possiblity that FT this is a signal transduction protein. Previously sequenced FT as TR:Q49739 (EMBL:U00015) (577 aa); Fasta score E(): 0, FT 99.8% identity in 577 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions in the C-terminal half. FT Contains Pfam match to entry PF00989 PAS, PAS domain. FT Contains Pfam match to entry PF00990 DUF9, Domain of FT unknown function. Contains PS01039 Bacterial extracellular FT solute-binding proteins, family 3 signature." FT /note="The C-terminal half is similar to ML1419. The FT N-terminal half shows some similarity to ML1750" FT /db_xref="GOA:Q9CCU8" FT /db_xref="InterPro:IPR000160" FT /db_xref="UniProtKB/TrEMBL:Q9CCU8" FT /protein_id="CAC29905.1" FT /translation="MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIESINPAATRILG FT LRAHDVVDMKHGHPFCFYDTDNQRVDLEREVMRVVRREVTTVSKVVGIDQHSGQRLWLS FT VNVSLLAYKAPPHSALVVSFSDISAHHLSIERLTYEATHDCLTGLANRRFAEDQITKSL FT QHDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQTVAQRLRSAVRPDDVVARLGGDE FT FIVLLRGPLSDMNANDVAKRLHTTLSESLVVDQLTVPIGASVGILEVRPDDRRRAADIL FT RDADSAMYAAKNKKQCAVTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVV FT LAIVGYGMTFVIMAGSVELSVGSIVALTGVTAALVAAQNQFAAIVTALLVGLAAGMVNG FT IVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILGAMGAMPWILIVCLFVT FT ILAGILFQFTMFGRWVKAIGGNERVATLAGVPTRGIKVAIFAICGLTAGLGGIVLASRL FT GAGTPTAATGFEIDVIAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAA FT SQIIKGIMLAAAVFVFLQRRKIGIIK" FT misc_feature complement(150128..150169) FT /note="PS01039 Bacterial extracellular solute-binding FT proteins, family 3 signature" FT misc_feature complement(150854..151348) FT /note="Pfam match to entry PF00990 DUF9, Domain of unknown FT function, score 238.20, E-value 1.1e-67" FT misc_feature complement(151592..151717) FT /note="Pfam match to entry PF00989 PAS, PAS domain, score FT 32.10, E-value 2.8e-07" FT CDS complement(152060..153097) FT /transl_table=11 FT /gene="ML0398" FT /product="putative D-ribose-binding protein" FT /note="Similar to many D-ribose-binding proteins e.g. FT Bacillus subtilis rbsB, D-ribose-binding protein precursor, FT SW:RBSB_BACSU (P36949) (305 aa); Fasta score E(): 2e-16, FT 32.6% identity in 273 aa overlap. Previously sequenced as FT TR:Q49738 (EMBL:U00015) (345 aa); Fasta score E(): 0, FT 100.0% identity in 345 aa overlap. Contains probable FT N-terminal signal sequence. Contains Pfam match to entry FT PF00532 Peripla_BP_like, Periplasmic binding proteins and FT sugar binding domain of the LacI family.." FT /db_xref="InterPro:IPR001761" FT /db_xref="UniProtKB/TrEMBL:Q49738" FT /protein_id="CAC29906.1" FT /translation="MSTGTSVPLRVASIMLILGLLPAILPACGFSESHHKLTIGVSYPT FT ANSPFWNAYTRFIDEGSHQLGVYINAVSAEEDEQKQLSDVETLINQGIDGLIVTPQSTS FT IAPTLLRIATQANIPVVVVDRYPGYAPGQNKNADYVAFLGPNNEKAGSGIAEALMAGGG FT SKFLALGGMPGNSVAQGRKAGLESALTAVGHRLVQFQYAGDSEDKGLAAAENMLQAHPA FT GDANAIWCFNDKLCQGAIKAVYNANREKEFIFGGMDLTPQAIAAIENGLYTVSLGAHWL FT EGGFGLAILYRKIHGQDPAERMVKLDLLKVDKSNVAKFKARYIDNTPHYNWKSTTPFDM FT TITLN" FT misc_feature complement(152240..152995) FT /note="Pfam match to entry PF00532 Peripla_BP_like, FT Periplasmic binding proteins and sugar binding domain of FT the LacI family., score 23.60, E-value 3.4e-07" FT RBS complement(153104..153109) FT /note="possible RBS" FT CDS 153357..154001 FT /pseudo FT /transl_table=11 FT /gene="ML0399" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3395c (Best blastx score 208)" FT CDS 154082..155157 FT /pseudo FT /transl_table=11 FT /gene="ML0400" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3394c (Best blastx score 268)" FT CDS complement(155303..155755) FT /pseudo FT /transl_table=11 FT /gene="ML0401" FT /product="phosphate transport system regulator FT (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue phoY2 (Best blastx score 152)" FT CDS complement(155941..156372) FT /pseudo FT /transl_table=11 FT /gene="ML0402" FT /product="putative cutinase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv1758 (Best blastx score 151)" FT CDS complement(156826..157747) FT /pseudo FT /transl_table=11 FT /gene="iunH" FT /gene_synonym="ML0403" FT /product="probable inosine-uridine preferring nucleoside FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT iunH (Best blastx score 213)" FT CDS 157850..158403 FT /pseudo FT /transl_table=11 FT /gene="cmaA1" FT /gene_synonym="ML0404" FT /product="cyclopropanemycolic acid synthase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT cmaA1 (Best blastx score 278)" FT RBS 159199..159204 FT /note="possible RBS" FT CDS 159217..160401 FT /transl_table=11 FT /gene="ML0405" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3616c, conserved FT hypothetical protein, TR:O06267 (EMBL:AL123456) (392 aa); FT Fasta score E(): 0, 62.7% identity in 394 aa overlap and to FT Rv3864, hypothetical protein, TR:P96213 (EMBL:AL123456) FT (402 aa); Fasta score E(): 2.1e-15, 31.0% identity in 410 FT aa overlap. Previously sequenced as TR:Q49722 (EMBL:U00015) FT (394 aa); Fasta score E(): 0, 100.0% identity in 394 aa FT overlap." FT /db_xref="UniProtKB/TrEMBL:Q49722" FT /protein_id="CAC29913.1" FT /translation="MSGAFIIDPTLKAIEAWHALLGIGVPNDGGVLYSSLSFFEKALEH FT LAAAFPGDGWLGSAADKYAGQNRKRVDIFQELAELDKELIELIHNQANSVQTTRGILDG FT AKKALLFVRPVAIDLNYIPLVGSVMSASIQAQACAAAMAAVSGGLAYLLVQTAIHTAKF FT VALLARLAHLLASAVADVVSDGVAIIKGIVDHLWHFIAGALTGLKDIVEKIIHWFFGLF FT SHWWSRLHSFFGGIPGLSGATSGLSQVTGLFGVPGLAGSSGLLSGESLLSTENLPSLAG FT VGAGLGLGSLPQLAQLHAASTRQGTRSQAGVSAELSTEQFGGQQEPVSAQGSQGMGGSQ FT GMGGMTPASTKSKKDERKKKKYSEGAAAGTDDAERAPIEVQSGGGKRALAQHVV" FT CDS 160459..160779 FT /transl_table=11 FT /gene="ML0406" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3615c, conserved FT hypothetical protein, TR:O06268 (EMBL:AL123456) (103 aa); FT Fasta score E(): 4.1e-19, 60.9% identity in 92 aa overlap FT and to Rv3865, hypothetical protein, TR:P96212 FT (EMBL:AL123456) (103 aa); Fasta score E(): 0.00022, 31.1% FT identity in 103 aa overlap. Previously sequenced as FT TR:Q49723 (EMBL:U00015) (106 aa); Fasta score E(): 0, FT 100.0% identity in 106 aa overlap." FT /db_xref="UniProtKB/Swiss-Prot:Q49723" FT /protein_id="CAC29914.1" FT /translation="MRSMIDNLTVQSEHLNSLASQHENEAACASSGVSAAAGLANAVST FT SHGSYCAQFNDTLKMYEDAHRTLGESLHTGGIDLARVLRVAAAMYCDADEICGSDIKSA FT FG" FT CDS 160793..161443 FT /transl_table=11 FT /gene="ML0407" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3614c, conserved FT hypothetical protein, TR:O06269 (EMBL:AL123456) (184 aa); FT Fasta score E(): 0, 71.5% identity in 186 aa overlap and to FT Rv3867, hypothetical protein, TR:O69732 (EMBL:AL123456) FT (183 aa); Fasta score E(): 2.1e-28, 51.4% identity in 175 FT aa overlap. Previously sequenced as TR:Q49730 (EMBL:U00015) FT (216 aa); Fasta score E(): 0, 100.0% identity in 216 aa FT overlap." FT /note="Similar to ML0056" FT /db_xref="UniProtKB/TrEMBL:Q49730" FT /protein_id="CAC29915.1" FT /translation="MGSRRRINRRLLPMSTFPAWQEFRRDVVVVFPGNDFDRDDCDTVD FT PWGVGGAAHWTIDPIVGFASSSAPQDRGTDVDNTRGQAEEDEKQKEPEVAIFTVTNPPR FT TVSVSVLMDGRIDHVELSKRVTWMSESQVASEILVLADLARQKAQSAQYTFILDKLSQL FT ADGDEHRVALLRESVGNTWNLPSPEQAAEAEAEVFATRYSDYCPAQDTENDQW" FT CDS 161777..162544 FT /pseudo FT /transl_table=11 FT /gene="ML0408" FT /product="possible IS1081 transposase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT IS1081 transposase (Best blastx score 140)" FT CDS complement(162861..163532) FT /pseudo FT /transl_table=11 FT /gene="ML0409" FT /product="possible IS6110 transposase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT IS6110 transposase (Best blastx score 164)" FT RBS 164310..164315 FT /note="possible RBS" FT misc_feature 164327..164599 FT /note="Pfam match to entry PF00934 PE, PE family, score FT 37.90, E-value 4.3e-08" FT CDS 164327..164629 FT /transl_table=11 FT /gene="ML0410" FT /product="putative PE-family protein" FT /note="Similar to M. tuberculosis PE-family proteins e.g. FT Rv2107, PE-family protein, TR:O33243 (EMBL:AL123456) (98 FT aa); Fasta score E(): 4.7e-08, 44.7% identity in 85 aa FT overlap. Contains Pfam match to entry PF00934 PE, PE FT family." FT /note="Similar to ML0538, ML1183 and ML1414" FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q49724" FT /protein_id="CAC29918.1" FT /translation="MSFFLRVEVGGLMMAAGRLERITSESMACNAKLTPVTTKVVPPAA FT DQVSKLVSQVFSSYGKQYEGYAAQGVDQSRLFVQSLKDAAGDYMDSDHMYLNTED" FT RBS 164740..164745 FT /note="possible RBS" FT CDS 164755..165981 FT /transl_table=11 FT /gene="ML0411" FT /product="serine-rich antigen" FT /note="Similar to M. tuberculosis PPE-family proteins e.g. FT Rv2108, PPE-family protein, TR:P95315 (EMBL:AL123456) (243 FT aa); Fasta score E(): 5.8e-17, 34.4% identity in 212 aa FT overlap. M. leprae serine-rich antigen (25L) (45 kDa FT protein). Previously sequenced as SW:SRA_MYCLE (Q07297) FT (408 aa); Fasta score E(): 0, 100.0% identity in 408 aa FT overlap. Contains Pfam match to entry PF00823 PPE, PPE FT family." FT /note="Similar to ML0539, ML1182 and ML1991" FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/Swiss-Prot:Q07297" FT /protein_id="CAC29919.1" FT /translation="MFDFMVYSPEVNAFLMSRGPGSTPLWGAAEAWISLAEQLMEAAQE FT VSDTIVVAVPASFAGETSDMLASRVSTFVAWLDGNAENAGLIARVLHAVAYAFEEARAG FT MVPLLTVLGNIIHTMALKAINWFGQVSTTVAALEADYDLMWVQNSTAMTTYRDTVLRET FT GKMENFEPAPQLVSRYCMDRRDSVNSFHSSSSSDSLYESIDNLYDSVAQSEEHGSDSMS FT QSYNTCGSVAQSELCDSPFGTPSQSSQSNDLSATSLTQQLGGLDSIISSASASLLTTNS FT ISSSTASSIMPIVASQVTETLGRSQVAVEKMIQSISSTAVSVDVAASKVVAGVGQAVSV FT GALRVPENWATASQPVMATAHSVPAGCSAITTAVSGPLEGVTQPAEEVLTASVAGGSGT FT GGPAFNEAV" FT misc_feature 164770..165246 FT /note="Pfam match to entry PF00823 PPE, PPE family, score FT 281.00, E-value 1.5e-80" FT CDS complement(166369..166981) FT /pseudo FT /transl_table=11 FT /gene="lpqD" FT /gene_synonym="ML0412" FT /product="putative lipoprotein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lpqD (Best blastx score 254)" FT CDS 167130..167983 FT /pseudo FT /transl_table=11 FT /gene="ML0413" FT /product="putative dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3389c (Best blastx score 301)" FT CDS complement(167984..169273) FT /transl_table=11 FT /gene="otsB2" FT /gene_synonym="ML0414" FT /product="putative trehalose-6-phosphate phosphatase" FT /note="Similar to M. tuberculosis otsB2, FT trehalose-6-phosphate phosphatase, TR:O50401 FT (EMBL:AL123456) (391 aa); Fasta score E(): 0, 67.1% FT identity in 425 aa overlap. Similar, except at N-terminus, FT to Arabidopsis thaliana tppB, trehalose-6-phosphate FT phosphatase, TR:O64897 (EMBL:AF007779) (374 aa); Fasta FT score E(): 2.2e-17, 31.1% identity in 315 aa overlap. FT Previously sequenced as TR:Q49734 (EMBL:U00015) (429 aa); FT Fasta score E(): 0, 100.0% identity in 429 aa overlap. FT Contains PS00402 Binding-protein-dependent transport FT systems inner membrane comp sign.." FT /db_xref="GOA:Q49734" FT /db_xref="InterPro:IPR003337" FT /db_xref="UniProtKB/Swiss-Prot:Q49734" FT /protein_id="CAC29922.1" FT /translation="MPVTIDPRRHSAALFDLDAVVTDTPLDSTVTLVRQLQGIGVGTAV FT FSTNRNSQGVLTATGLDHLFPVHVDGLASGKVTILVAAANRLMAQPGRCVVVAVDAAGI FT TAARYGGFALVLGLVIGEDQTGHRDTLRNSGADTVVADLGEVIVRTGDRRMSELPDALQ FT TLGLTDDLTARQPAVFFDFDGTLSDIVDDPDSARPVPGATEALQKLATHCPVAILSGRD FT LADVIKRIGVPGIWYSGSHGFESTAPDGTHHQNDAAEATIPILEQAATQLRDQLGPIPG FT VMVEHKRFGVAVHYRNVARDRVNEVAVAVRTAGQRNALRVTTGREVIELRPDIDWDKGK FT TLHWVIDRLHHAGTQVGSASLMPICLGDDITDEDAFDAVRHTDVGGIPIVVRHTEDGNR FT ATAALFTLDSPMHVSEFTERLARQLSDTQR" FT misc_feature complement(168485..168571) FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp sign." FT CDS complement(169499..170618) FT /pseudo FT /transl_table=11 FT /gene="ML0415" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3371c (Best blastx score 169)" FT CDS 170919..173123 FT /pseudo FT /transl_table=11 FT /gene="dnaE2" FT /gene_synonym="ML0416" FT /product="DNA polymerase III [alpha] chain (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT dnaE2 (Best blastx score 538)" FT CDS complement(173299..173583) FT /pseudo FT /transl_table=11 FT /gene="ML0417" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3369 (Best blastx score 151)" FT CDS 173644..174276 FT /transl_table=11 FT /gene="ML0418" FT /product="putative oxidoreductase" FT /note="Similar to M. tuberculosis Rv3368c, conserved FT hypothetical protein, TR:O50397 (EMBL:AL123456) (214 aa); FT Fasta score E(): 0, 81.9% identity in 210 aa overlap. Shows FT weak similarity Thermus aquaticus nox, NADH dehydrogenase, FT SW:NOX_THETH (X60110) (205 aa); Fasta score E(): 0.00023, FT 28.8% identity in 212 aa overlap. Previously sequenced as FT TR:O07697 (EMBL:Z97179) (210 aa); Fasta score E(): 0, 99.5% FT identity in 210 aa overlap. Contains Pfam match to entry FT PF00881 Nitroreductase, Nitroreductase family. Contains FT PS00402 Binding-protein-dependent transport systems inner FT membrane comp sign.." FT /db_xref="GOA:O07697" FT /db_xref="InterPro:IPR000415" FT /db_xref="UniProtKB/TrEMBL:O07697" FT /protein_id="CAC29926.1" FT /translation="MSVDEVLTTTRSVRKRLDFDKPVPRDVLMECLQLALQAPTGSNSQ FT GWHWVFVEDAEKRKAIGDIYLVNARCYLSQPAPEYPEGDTRGERMRLVRDSATYLAEHM FT HEVPVLLIPCLLGRAEESPLGAVSYWASLFPAVWSFCLALRSRGLGTCWTSLHLLGDGE FT QRAAEVLGIPSDKYSQGGLFPIAYTKGTDFRPANRLPAENVTHWDIW" FT misc_feature 173680..174150 FT /note="Pfam match to entry PF00881 Nitroreductase, FT Nitroreductase family, score 146.20, E-value 5.9e-40" FT misc_feature 174109..174195 FT /note="PS00402 Binding-protein-dependent transport systems FT inner membrane comp sign." FT CDS complement(174414..174890) FT /transl_table=11 FT /gene="ML0419" FT /product="putative tRNA/rRNA methyltransferase" FT /note="Similar to M. tuberculosis spoU, Rv3366, possible FT RNA methyltransferase, TR:O50394 (EMBL:AL123456) (154 aa); FT Fasta score E(): 0, 83.8% identity in 154 aa overlap. Shows FT weak similarity to Escherichia coli spoU, tRNA FT (guanosine-2'-o-)-methyltransferase, SW:TRMH_ECOLI (P19396) FT (229 aa); Fasta score E(): 4e-05, 30.4% identity in 148 aa FT overlap. Similar to many hypothetical RNA FT methyltranferases. Previously sequenced as TR:O07698 FT (EMBL:Z97179) (169 aa); Fasta score E(): 0, 100.0% identity FT in 158 aa overlap. Contains Pfam match to entry PF00588 FT SpoU_methylase, SpoU rRNA Methylase family." FT /db_xref="GOA:Q9CCU7" FT /db_xref="HSSP:1MXI" FT /db_xref="InterPro:IPR016914" FT /db_xref="UniProtKB/TrEMBL:Q9CCU7" FT /protein_id="CAC29927.1" FT /translation="MISKMFRLLFYTPRIPPNTGNAIRTAAVTGCALHLVEPIGFDLSN FT PKLRRAGLDYHDLASVTVHTSLSEAWNALSPARVFAFSTLANTLFTDVSYQAGDVLMFG FT PEPTGLDAATLADDHITQQVRIPMLSGRRSLNLSNAAAVAVYEAWRQHGYAGLV" FT misc_feature complement(174453..174878) FT /note="Pfam match to entry PF00588 SpoU_methylase, SpoU FT rRNA Methylase family, score 120.50, E-value 3.1e-32" FT CDS 175275..177679 FT /pseudo FT /transl_table=11 FT /gene="ML0420" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3365c (Best blastx score 540)" FT CDS 177734..178126 FT /pseudo FT /transl_table=11 FT /gene="ML0421" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3364c (Best blastx score 181)" FT CDS 178247..178813 FT /pseudo FT /transl_table=11 FT /gene="ML0422" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3362c (Best blastx score 425)" FT CDS 178864..179111 FT /pseudo FT /transl_table=11 FT /gene="ML0423" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3361c (Best blastx score 162)" FT repeat_region 179180..179810 FT /note="Dispersed repeat, RLEP, copy 7" FT CDS complement(179803..180288) FT /transl_table=11 FT /gene="bcp" FT /gene_synonym="ML0424" FT /product="putative antioxidant protein" FT /note="Similar to M. tuberculosis bcp, Rv2521, FT bacterioferritin comigratory protein, TR:O5322 FT (EMBL:AL123456) (157 aa); Fasta score E(): 0, 79.6% FT identity in 157 aa overlap. Similar to many members of the FT AhpC/TSA family, suggesting a protective, antioxidant role. FT e.g. shows similarity to Sedum lineare prxQ, peroxiredoxin FT Q, TR:BAA90524 (EMBL:AB037598) (186 aa); Fasta score E(): FT 3e-17, 40.0% identity in 155 aa overlap and weak similarity FT to Mus musculus tdpX1, thioredoxin peroxidase 1, FT SW:TDX1_MOUSE (Q61171) (343 aa); BlastP Expect 8.8. FT Previously sequenced as TR:O07705 (EMBL:Z97179) (161 aa); FT Fasta score E(): 0, 99.4% identity in 161 aa overlap. FT Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA FT family." FT /db_xref="GOA:O07705" FT /db_xref="InterPro:IPR017936" FT /db_xref="UniProtKB/TrEMBL:O07705" FT /protein_id="CAC29932.1" FT /translation="MTETTRLAPGDQAPAFSLPDADGRIVSLGDYRGQRVTVYFYPAAL FT TPGCTKQACDFRDNLHDLNDAGLDVVGISPDPLTKLAEFRDAEALTFPLLSDHDCKVLS FT AWGAYGKKQIYGKTVLGVIRSTFVVDEKGKIVLAQYNVKATGHVAKLRRDLSLLECC" FT misc_feature complement(179827..180264) FT /note="Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA FT family, score 117.20, E-value 3.1e-31" FT RBS complement(180293..180297) FT /note="possible RBS" FT RBS 180403..180407 FT /note="possible RBS" FT CDS 180416..180643 FT /transl_table=11 FT /gene="ML0425" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv2520c, hypothetical FT protein, TR:O53225 (EMBL:AL123456) (75 aa); Fasta score FT E(): 2.2e-15, 57.3% identity in 75 aa overlap. Previously FT sequenced as TR:O07706 (EMBL:Z97179) (91 aa); Fasta score FT E(): 7.9e-29, 100.0% identity in 75 aa overlap. Contains FT hydrophobic, possible membrane-spanning region." FT /db_xref="UniProtKB/TrEMBL:Q9CCU6" FT /protein_id="CAC29933.1" FT /translation="MADRHPDTIKLEIDVAREQFAATVDSLAERANPRRLAGDLKARVV FT EFGRRPAVIAALVSCAVLTVIVVVRKVKNR" FT tRNA complement(180675..180750) FT /gene="lysU" FT /note="tRNA Lys anticodon CTT, Cove score 84.12" FT CDS 180929..182143 FT /transl_table=11 FT /gene="lppS" FT /gene_synonym="ML0426" FT /product="putative secreted protein" FT /note="Similar to M. tuberculosis lppS, Rv2518c, putative FT lipoprotein, TR:O53223 (EMBL:AL021185) (408 aa); Fasta FT score E(): 0, 82.6% identity in 403 aa overlap. Does not FT contain a predicted membrane lipoprotein lipid attachment FT site (present in lppS), but does contain a possible FT N-terminal signal sequence. Similar to many predicted FT lipoproteins from Streptomyces coelicolor. Previously FT sequenced as TR:O07707 (EMBL:Z97179) (407 aa); Fasta score FT E(): 0, 100.0% identity in 404 aa overlap." FT /note="Similar to ML0569, ML2446 and ML2664" FT /db_xref="InterPro:IPR005490" FT /db_xref="UniProtKB/TrEMBL:Q9CCU5" FT /protein_id="CAC29934.1" FT /translation="MGTATRRVQPKAWRALLTLLVISVVMPGVACNRGGGNVPVNVIGD FT KGTPFADLLVPKLTASVTDGAVGVNVDMPVTVTVADGVLAAVTMINDNGRMINGQFSPD FT GLRWSTTEPLGFNRCYTLSAKALGLGGVVNRQMTFQTSSPAHLTMPYVNPGNGEIVGIG FT EPVAIRFDENIANRLAAQKAITITANPPVEGAFYWLNNREVRWRPEHFWKSGTAVDVAV FT NTYGVDLGEGMFGEDNVKTHFTIGDEVFATADDATKMLTVRVNGEVVKIMPTSMGKDST FT PTANGIYIVGARFKHIIMDSSTYGVPVNSPNGYRADVDWATQLSYSGVFLHSAPWSVGA FT QGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNTVGDTLPGAEGLGDWNIPWEQWKA FT GNANI" FT tRNA complement(182168..182243) FT /gene="hisT" FT /note="tRNA His anticodon GTG, Cove score 82.48" FT CDS complement(182294..182941) FT /transl_table=11 FT /gene="ML0427" FT /product="putative oligoribonuclease" FT /note="EC_number=3.1.-.-" FT /note="Similar to M. tuberculosis orn, Rv2511, putative FT oligoribonuclease, SW:ORN_MYCTU (O06174) (215 aa); Fasta FT score E(): 0, 84.5% identity in 213 aa overlap. Similar to FT many e..g Escherichia coli orn, oligoribonuclease, FT SW:ORN_ECOLI (P39287) (180 aa); Fasta score E(): 8.2e-25, FT 45.3% identity in 172 aa overlap. Previously sequenced as FT SW:ORN_MYCLE (O07708) (215 aa); Fasta score E(): 0, 99.5% FT identity in 215 aa overlap." FT /db_xref="GOA:O07708" FT /db_xref="HSSP:1J9A" FT /db_xref="InterPro:IPR006055" FT /db_xref="UniProtKB/Swiss-Prot:O07708" FT /protein_id="CAC29935.1" FT /translation="MHDELVWIDCEMTGLDLGSDQLIEIAALVTDADLNILGDGVDVVI FT HIDSTALSSMIDVVAEMHSRSGLINEVESSIVDLVTAESIVLDYINNHVKQPKTAPLAG FT NSIATDRSFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPAKGLTHRALADI FT HESIRELRFYRRTAFVPPPGPSTREIAEVVADLSGTPATPGDIDSAYERPNG" FT CDS 183082..184557 FT /pseudo FT /transl_table=11 FT /gene="ML0428" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2510c (Best blastx score 399)" FT CDS complement(184621..185427) FT /transl_table=11 FT /gene="ML0429" FT /product="putative oxidoreductase" FT /note="Similar to M. tuberculosis Rv2509, putative FT oxidoreductase, TR:O06172 (EMBL:AL123456) (268 aa); Fasta FT score E(): 0, 88.8% identity in 267 aa overlap. Similar to FT many putative dehydrogenases. Previously sequenced as FT TR:O07709 (EMBL:Z97179) (268 aa); Fasta score E(): 0, FT 100.0% identity in 268 aa overlap. Contains Pfam match to FT entry PF00106 adh_short, short chain dehydrogenase. FT Contains PS00061 Short-chain dehydrogenases/reductases FT family signature." FT /db_xref="GOA:O07709" FT /db_xref="HSSP:1FDS" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O07709" FT /protein_id="CAC29937.1" FT /translation="MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVIARREDV FT LVDLAARLADKYRVAVEVRPADLTDPSERVKLADELTVRPISILCANAGTATFGPVSAL FT DPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAGNSPIPYNATYAATKAF FT ANTFSESLRGELHGSGVHVTLLAPGPVRTELPDHDEASLVEKLVPDFLWISTEHTARLS FT LDALERNKMRVVPGLTSKAMSVASRYAPRAIVASIVGNFYKKLGGG" FT misc_feature complement(184849..185400) FT /note="Pfam match to entry PF00106 adh_short, short chain FT dehydrogenase, score 103.40, E-value 4.3e-27" FT misc_feature complement(184912..184998) FT /note="PS00061 Short-chain dehydrogenases/reductases family FT signature" FT CDS 185520..186884 FT /transl_table=11 FT /gene="ML0430" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv2508c, putative FT membrane protein, TR:O06171 (EMBL:AL123456) (445 aa); Fasta FT score E(): 0, 75.7% identity in 441 aa overlap. Also FT similar to Streptomyces coelicolor SC6D7.19C, putative FT integral membrane protein, TR:Q9RKX9 (EMBL:AL133213) (486 FT aa); Fasta score E(): 1.5e-13, 29.7% identity in 445 aa FT overlap. Previously sequenced as TR:O07710 (EMBL:Z97179) FT (464 aa); Fasta score E(): 0, 100.0% identity in 454 aa FT overlap. Contains hydrophobic, possible membrane-spanning FT regions." FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q9CCU4" FT /protein_id="CAC29938.1" FT /translation="MNQPESVAGTMVRSWVVAWAMWDCGSTGLTAIVATFVFSVYLTSS FT VGVGMPDGISLVSWLGRAGAVAGLTIAVLAPAIGVWVESPHRRRVTLGVLTVLAVALTC FT GMSFIRDQPSYLWAGLMLLAGTAACGDLASVPYNAMLRQLSTPATAGRISGLGWASGYV FT GSVVLLLLIYLGFISGTGELRGLLQLPTHDGIYVRAAMLLAAAWLALLALPLLLTAHRL FT PSLGEVSHPTSMLGGYRKLWSEVSAEWRRDRNLVYFLVASALFRDGLAATLGFGAVLGV FT NAYGISQANVLMFGVVASLVAAVGAVLGGFVDHRIGSKRVIVGSLVAIIVTALTLMTLS FT GPLAFWVCGLVLCLFIGPSQSSSRALLLHMAKHGREGVAFGLYTMTGRAASFVAPWSFS FT IFVDGFGVVRAGLGGISVVLLAGLLGMLMVRVPTRREAAAVGLSWWRSQARRGQV" FT CDS complement(186916..187695) FT /transl_table=11 FT /gene="ML0431" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv2507, putative membrane FT protein, TR:O06170 (EMBL:AL123456) (273 aa); Fasta score FT E(): 0, 60.4% identity in 275 aa overlap. Previously FT sequenced as TR:O07711 (EMBL:Z97179) (261 aa); Fasta score FT E(): 0, 100.0% identity in 259 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CCU3" FT /protein_id="CAC29939.1" FT /translation="MNNPRRSEWLGPSLAGSGPIEPQVHQYPPLTDPAYAEQAPYAPAY FT GASLPPWTPKKPPQQLPRYWQQDQPPPTDIPPEGLTLPPPHEPKSPHWFLWVVAGASVV FT LVVGLVMALIIANGAIKTQTAVPPLPAITESSSATPTPTTKTSPTPTAGPAPSTTGSGT FT LTQTIGPSAMLDVVYSITGQGRAISVTYMDTGDVIQTEFNVVLPWSKQVSLSKSAVHPA FT SVTIVNIGHDVTCSVTVAGVQIRQHTGVGLTICDAPR" FT RBS complement(187699..187704) FT /note="possible RBS" FT CDS complement(187814..188464) FT /pseudo FT /transl_table=11 FT /gene="ML0432" FT /product="transcriptional regulator (TetR/AcrR family) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2506 (Best blastx score 173)" FT CDS 188614..189912 FT /pseudo FT /transl_table=11 FT /gene="fadD35" FT /gene_synonym="ML0433" FT /product="acyl-CoA synthase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadD35 (Best blastx score 403)" FT CDS 190033..190710 FT /pseudo FT /transl_table=11 FT /gene="scoA" FT /gene_synonym="ML0434" FT /product="3-oxo acid:CoA transferase, [alpha] subunit FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT scoA (Best blastx score 439)" FT CDS 190769..191414 FT /pseudo FT /transl_table=11 FT /gene="scoB" FT /gene_synonym="ML0435" FT /product="3-oxo acid:CoA transferase, [beta] subunit FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT scoB (Best blastx score 465)" FT CDS 191414..193000 FT /pseudo FT /transl_table=11 FT /gene="accD1" FT /gene_synonym="ML0436" FT /product="acetyl/propionyl-CoA carboxylase, [beta] subunit FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT accD1 (Best blastx score 396)" FT CDS 193009..194544 FT /pseudo FT /transl_table=11 FT /gene="accA1" FT /gene_synonym="ML0437" FT /product="acetyl/propionyl-CoA carboxylase, [alpha] subunit FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT accA1 (Best blastx score 865)" FT CDS 194598..195715 FT /pseudo FT /transl_table=11 FT /gene="fadE19" FT /gene_synonym="ML0438" FT /product="acyl-CoA dehydrogenase (aka mmgC) (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE19 (Best blastx score 346)" FT CDS 195670..196204 FT /pseudo FT /transl_table=11 FT /gene="ML0439" FT /product="putative aldehyde dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2499c (Best blastx score 164)" FT CDS 196204..196782 FT /pseudo FT /transl_table=11 FT /gene="citE" FT /gene_synonym="ML0440" FT /product="citrate lyase [beta] chain (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT citE (Best blastx score 389)" FT CDS 196802..197460 FT /pseudo FT /transl_table=11 FT /gene="pdhA" FT /gene_synonym="ML0441" FT /product="pyruvate dehydrogenase E1 component [alpha] FT subunit (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pdhA (Best blastx score 325)" FT CDS 197506..198532 FT /pseudo FT /transl_table=11 FT /gene="pdhB" FT /gene_synonym="ML0442" FT /product="pyruvate dehydrogenase E1 component [beta] FT subunit (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pdhB (Best blastx score 387)" FT CDS 198561..199749 FT /pseudo FT /transl_table=11 FT /gene="pdhC" FT /gene_synonym="ML0443" FT /product="dihydrolipoamide acetyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pdhC (Best blastx score 324)" FT CDS complement(200151..201199) FT /pseudo FT /transl_table=11 FT /gene="ML0444" FT /product="group II intron maturase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv0071 (Best blastx score 239)" FT repeat_region complement(200404..201582) FT /note="1179 bp 100% identical to region 2003855..2005033" FT CDS complement(202027..202564) FT /pseudo FT /transl_table=11 FT /gene="ML0445" FT /product="REP-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis REP-family FT protein (Best blastx score 218)" FT CDS complement(202688..203132) FT /pseudo FT /transl_table=11 FT /gene="ML0446" FT /product="enoyl-CoA hydratase/isomerase superfamily FT (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue echA14 (Best blastx score 194)" FT repeat_region complement(203228..203967) FT /note="740 bp 100% identical to region 2562936..2563675" FT CDS 203312..203788 FT /transl_table=11 FT /gene="ML0447" FT /product="hypothetical protein" FT /note="Similar to region of cytochrome P450s e.g. Bacillus FT megaterium CYP102A1, cytochrome P450(BM-3), SW:CPXB_BACME FT (P14779) (1048 aa); Fasta score E(): 0.00033, 31.8% FT identity in 132 aa overlap. previously sequenced as FT TR:O07142 (EMBL:Z96801) (126 aa); Fasta score E(): 0, 99.2% FT identity in 126 aa overlap." FT /db_xref="GOA:Q9CCU2" FT /db_xref="UniProtKB/TrEMBL:Q9CCU2" FT /protein_id="CAC29955.1" FT /translation="MLYSADPSTGEQLDTDNVVNQILTLLVSGSQTLANAIAFALHYLL FT SIHHDIAAQTRREIYQNRSDRGIANVSYCSAMSLNCDAYVVSSTQLCGCGLVVPCYLRQ FT ARRDTTLGNGTSLFHKGQWVIVLLTAPMPGGPMLTNSTPTESCRKFAGSCPVYL" FT CDS 203992..204264 FT /transl_table=11 FT /gene="ML0448" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O07143 FT (EMBL:Z96801) (90 aa); Fasta score E(): 0, 100.0% identity FT in 90 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O07143" FT /protein_id="CAC29956.1" FT /translation="MQAWYVSSVGCCYFGLECHVVRVKGRPITAQQTSVSAASWYKPKG FT TMEQKVFRIVTDRDSLCQNVYVYVGTGPDSMFAAAAKCGEHVIMR" FT CDS complement(205366..206149) FT /pseudo FT /transl_table=11 FT /gene="tesB2" FT /gene_synonym="ML0449" FT /product="thioesterase II (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT tesB2 (Best blastx score 159)" FT CDS complement(206193..207116) FT /transl_table=11 FT /gene="ML0450" FT /product="putative pyridoxine biosynthesis protein" FT /note="Similar to M. tuberculosis Rv2606c, hypothetical FT protein, SW:YQ06_MYCTU (O06208) (299 aa); Fasta score E(): FT 0, 89.7% identity in 291 aa overlap. Highly conserved in FT both bacteria and eukaryotes. Similar to Emericella FT nidulans pyroA, pyridoxine biosynthesis protein, TR:Q9UW83 FT (EMBL:AF133101) (304 aa); Fasta score E(): 0, 65.9% FT identity in 299 aa overlap. Previously sequenced as FT SW:YQ06_MYCLE (O07145) (333 aa); Fasta score E(): 0, 100.0% FT identity in 307 aa overlap. Contains Pfam match to entry FT PF01680 UPF0019, Uncharacterized protein family SNZ. FT Contains PS01235 Uncharacterized protein family UPF0019 FT signature." FT /db_xref="GOA:O07145" FT /db_xref="InterPro:IPR001852" FT /db_xref="UniProtKB/Swiss-Prot:O07145" FT /protein_id="CAC29958.1" FT /translation="MDSAAQSNQAQSVFGQTGTARVKRGMAEMLKGGVIMDVVIPEQAR FT IAEGSGAVAVMALERVPSDIRAQGGVSRMSDPDMIESIIAAVTIPVMAKARIGHFVEAQ FT ILQSLGVDYIDESEVLTPADYTHHIDKWKFTVPFVCGATNLGEALRRINEGAAMIRSKG FT EAGTGDVSNATTHMRAIAGDIRRLTSLSEDELYVAAKELHAPYELVIEVARTNKLPVTL FT FTAGGIATPADAAMMMQLGAEGIFVGSGIFKSSDPAQRAAAIVKATTFYDDPDVLAKVS FT RGLGEAMAGIDVEQIAQPDRLAQRGW" FT misc_feature complement(206409..206465) FT /note="PS01235 Uncharacterized protein family UPF0019 FT signature" FT misc_feature complement(206442..207062) FT /note="Pfam match to entry PF01680 UPF0019, Uncharacterized FT protein family SNZ, score 443.10, E-value 2.4e-129" FT CDS complement(207191..208240) FT /transl_table=11 FT /gene="ML0451" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2609c, conserved FT hypothetical protein, TR:O06205 (EMBL:AL123456) (351 aa); FT Fasta score E(): 0, 77.7% identity in 336 aa overlap. FT Similar, in part, to hypothetical proteins from FT Streptomyces coelicolor e.g. SC2E1.17, hypothetical FT protein, TR:O69888 (EMBL:AL023797) (172 aa); Fasta score FT E(): 2e-13, 43.3% identity in 150 aa overlap. Previously FT sequenced as TR:O07146 (EMBL:Z96801) (349 aa); Fasta score FT E(): 0, 100.0% identity in 349 aa overlap. Contains PS00893 FT mutT domain signature." FT /db_xref="GOA:O07146" FT /db_xref="HSSP:1IRY" FT /db_xref="InterPro:IPR020084" FT /db_xref="UniProtKB/TrEMBL:O07146" FT /protein_id="CAC29959.1" FT /translation="MLTLLVLLVALATLAGGWGYQTANRLNRLHVRYDLSWQALDGALA FT RRAVVARAVAIDAYSGTSPGRRLAALADAAECAPRHTRENAENELSAALAMVDPASLPT FT ALIAELADAEARVLLARRFHNDAVRDTLALGEQRLVRTLRLRGTASVPTYFEIVERPHA FT LTHGDHGVPNQRTSARVVLLDETGAVLLLCGSDPAITNGHAPRWWITVGGEVRPGERLA FT AAAARELAEETGLRVIPTHMVGPIWRRDAIFEFNGSVIDSEEFYLVYRTRRFEPSTVGW FT TELEHLCLHGSRWCDANDIAELVASGEQVYPRQLGELLPVANQLADASTGTARGTAAAR FT NTYVLLSIC" FT misc_feature complement(207545..207604) FT /note="PS00893 mutT domain signature" FT CDS complement(208240..209364) FT /transl_table=11 FT /gene="ML0452" FT /product="putative glycosyltransferase" FT /note="Similar to M. tuberculosis Rv2610c putative FT glycosyltransferase, TR:O06204 (EMBL:AL123456) (378 aa); FT Fasta score E(): 0, 82.3% identity in 378 aa overlap. FT Similar to Synechococcus sp. sqdX, required for FT biosynthesis of the sulfolipid FT sulfoquinovosyldiacylglycerol, TR:Q9R6U1 (EMBL:U45308) (377 FT aa); Fasta score E(): 6.9e-12, 25.9% identity in 390 aa FT overlap and to CDS from the Bordetella parapertussis FT ipopolysaccharide biosynthesis locus e.g. wlbH, putative FT glcNac transferase, TR:O52848 (EMBL:AJ224768) (390 aa); FT Fasta score E(): 6.1e-12, 27.3% identity in 392 aa overlap. FT Previously sequenced as TR:O07147 (EMBL:Z96801) (374 aa); FT Fasta score E(): 0, 100.0% identity in 374 aa overlap. FT Contains Pfam match to entry PF00534 Glycos_transf_1, FT Glycosyl transferases group 1. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /note="Show weak similarity to ML0886, ML1715 and ML2443" FT /db_xref="GOA:O07147" FT /db_xref="InterPro:IPR001296" FT /db_xref="PDB:2GEJ" FT /db_xref="UniProtKB/Swiss-Prot:O07147" FT /protein_id="CAC29960.1" FT /translation="MRIGMICPYSFDVPGGVQSHVLQLAEVMRARGQQVRVLAPASPDV FT SLPEYVVSAGRAIPIPYNGSVARLQFSPAVHSRVRRWLVDGDFDVLHLHEPNAPSLSMW FT ALRVAEGPIVATFHTSTTKSLTLSVFQGVLRPWHEKIIGRIAVSDLARRWQMEALGSDA FT VEIPNGVNVDSLSSAPQLAGYPRLGKTVLFLGRYDEPRKGMSVLLDALPGVMECFDDVQ FT LLIVGRGDEEQLRSQAGGLVEHIRFLGQVDDAGKAAAMRSADVYCAPNIGGESFGIVLV FT EAMAAGTPVVASDLDAFRRVLRDGEVGHLVPAGDSAALADALVALLRNDVLRERYVAAG FT AEAVRRYDWSVVASQIMRVYETVATSGSKVQVAS" FT misc_feature complement(208336..208800) FT /note="Pfam match to entry PF00534 Glycos_transf_1, FT Glycosyl transferases group 1, score 113.20, E-value FT 2.7e-30" FT misc_feature complement(208795..208818) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(209374..210336) FT /transl_table=11 FT /gene="ML0453" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2611c, conserved FT hypothetical protein, TR:O06203 (EMBL:AL123456) (316 aa); FT Fasta score E(): 0, 71.5% identity in 312 aa overlap. Shows FT weak similarity to putative acyltransferases e.g. FT Campylobacter jejuni lipid A biosynthesis acyltransferase, FT TR:AAF31766 (EMBL:AF130984) (295 aa); Fasta score E(): FT 0.00017, 20.0% identity in 180 aa overlap. previously FT sequenced as TR:O07148 (EMBL:Z96801) (320 aa); Fasta score FT E(): 0, 99.7% identity in 320 aa overlap." FT /db_xref="GOA:O07148" FT /db_xref="InterPro:IPR004960" FT /db_xref="UniProtKB/TrEMBL:O07148" FT /protein_id="CAC29961.1" FT /translation="MTTSTAGLKMIRAPHRLMTGRAIDWAYAAGWRAVRAMPESAARFA FT FNTGARYAARNGGPDQLRKNLARIIGVQAADVPDALIRTSLASYARYWREAFRLPTMNP FT HTVAKQVEAYGIDLHRVGEALDAGRGVVLALPHSGNWDMAGVWLVQCHGTFTTVAERLK FT PESLYRRFINYRENLGFEVLPMSANKDTGFQALFELLCERLRSNRVVCLMAERDLTRTG FT VEVDFFGEPTRMPAGPAKLAIKTGAALLPVHCWFQGSGWGFSVHPALDCTSGDVGDVTQ FT ALADQFAQDIAANPTDWHMLQPQWLADLSDAKRAQLRPN" FT CDS complement(210333..211052) FT /transl_table=11 FT /gene="pgsA" FT /gene_synonym="ML0454" FT /product="putative phosphatidyltransferase" FT /note="Similar to M. tuberculosis pgsA, Rv2612c, putative FT CDP-alcohol phosphatidyltransferases, TR:O06202 FT (EMBL:AL123456) (217 aa); Fasta score E(): 0, 79.3% FT identity in 213 aa overlap. Shows weak similarity to FT Escherichia coli pgsA, FT CDP-diacylglycerol--glycerol-3-phosphate FT 3-phosphatidyltransferase, SW:PGSA_ECOLI (P06978) (738 aa); FT BlastP Expect 8.6. Previously sequenced as TR:O07149 FT (EMBL:Z96801) (239 aa); Fasta score E(): 0, 100.0% identity FT in 239 aa overlap. Contains Pfam match to entry PF01066 FT CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. FT Contains PS00379 CDP-alcohol phosphatidyltransferases FT signature." FT /db_xref="GOA:O07149" FT /db_xref="InterPro:IPR000462" FT /db_xref="UniProtKB/TrEMBL:O07149" FT /protein_id="CAC29962.1" FT /translation="MSKVPFLSRATFTRLTTPTARALLRVGLTPDAITVLGTIVAASGA FT LVLFPIGKLFAGTLVVWFFVLFDMLDGAMARERGGGTRYGAVLDATCDRISDGAVFCGL FT LWWMAFGLHSKHLVVATLICLVTSQVISYIKARAEASGLRGDDGLIERPERLIIVLVGA FT GLSDFPVYSLPWALSVAMWLLVVASLITCAQRLHTVHTSPGATDRIARPGYPSASDRTN FT ATNGGQPGPGNLGTGEP" FT misc_feature complement(210447..210881) FT /note="Pfam match to entry PF01066 CDP-OH_P_transf, FT CDP-alcohol phosphatidyltransferase, score 103.60, E-value FT 3.9e-27" FT misc_feature complement(210774..210842) FT /note="PS00379 CDP-alcohol phosphatidyltransferases FT signature" FT CDS complement(211049..211669) FT /transl_table=11 FT /gene="ML0455" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2613c, conserved FT hypothetical protein, TR:O06201 (EMBL:AL123456) (195 aa); FT Fasta score E(): 0, 84.7% identity in 196 aa overlap. FT Similar to many HIT-family hypothetical proteins. FT Previously sequenced as TR:O07150 (EMBL:Z96801) (186 aa); FT Fasta score E(): 0, 100.0% identity in 186 aa overlap. FT Contains Pfam match to entry PF01230 HIT, HIT family." FT /db_xref="GOA:Q9CCU0" FT /db_xref="HSSP:1FIT" FT /db_xref="InterPro:IPR011151" FT /db_xref="UniProtKB/TrEMBL:Q9CCU0" FT /protein_id="CAC29963.1" FT /translation="MSEQERPDTRADHTDGTILDMGVGERDHLQRLWTPYRMTYLAEAP FT VNHDNSTPAQPFTDIPQLSDEDGLVVARGELVYAVLNLYPYNPGHLMVVPYRQVSELED FT LTDAESAELMTFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDA FT NFITIIGGSKVIPQLLRDTRQLLATEWTKQFMSRSGDDAERSL" FT misc_feature complement(211196..211507) FT /note="Pfam match to entry PF01230 HIT, HIT family, score FT 45.80, E-value 9.3e-10" FT CDS complement(211662..213770) FT /transl_table=11 FT /gene="thrS" FT /gene_synonym="ML0456" FT /product="threonyl-tRNA synthetase" FT /EC_number="6.1.1.3" FT /note="Similar to M. tuberculosis thrS, Rv2614c, FT threonyl-tRNA synthetase, SW:SYT_MYCTU (O06200) (692 aa); FT Fasta score E(): 0, 84.0% identity in 702 aa overlap. FT Similar to many e.g. Thermus aquaticus thrS, threonyl-tRNA FT synthetase, SW:SYT_THETH (P56881) (659 aa); Fasta score FT E(): 0, 45.0% identity in 645 aa overlap. Previously FT sequenced as SW:SYT_MYCLE (O07151) (702 aa); Fasta score FT E(): 0, 100.0% identity in 702 aa overlap. Contains Pfam FT match to entry PF00587 tRNA-synt_2b, tRNA synthetase class FT II (G, H, P, S and T). Contains PS00339 Aminoacyl-transfer FT RNA synthetases class-II signature 2. Contains PS00179 FT Aminoacyl-transfer RNA synthetases class-II signature 1." FT /db_xref="GOA:O07151" FT /db_xref="HSSP:1EVL" FT /db_xref="InterPro:IPR012947" FT /db_xref="UniProtKB/Swiss-Prot:O07151" FT /protein_id="CAC29964.1" FT /translation="MSAPVHPVPGADGGDPLRPATPGLRSPQVPIQVPAGSTAAAAVSE FT AGLPTHGAPDAIVVVRDADGKLRDLSWVPDVDVEVTPVPVNTDDGRSVIRHSTAHVLAQ FT AVQDLFPQAKLGIGPPITDGFYYDFDVAEPFTPEDLKALEKRMRQIVKEGQLFSRRIYE FT SKEQARTEWAGEPYKLELVDDESGDAEIMEVGGDELTAYDNLNARNGERIWGDLCRGPH FT IPTTKHIPAFKLTRSSAAYWRGNQKNASLQRIYGTAWESQEALDRHLEMITEAQRRDHR FT KLGIELDLFSFPDEIGSGLAIFHPKGSIVRREMEEYSRRKHIEAGYQFVNTPHITKAQL FT FHTSGHLDWYAEGIFPPMHLDAEHNDDGTVRKPGQDYYLKPMNCPMHTLIFSSRGRSYR FT ELPLRLFEFGTIYRYEKSGVVHGLTRARGFTMDDSHIFCTREQLHCELASLLRFVLDLL FT GDYGLEDFYLELSTKDPEKFVGSEEIWEEATAALAEVAENSTLPLVPDPGGAAFYGPKI FT SVQVRDALGRSWQMSTIQVDFNFPERFALEYTSADGTRQRPVMIHRALFGSIERFFGIL FT TEHYAGAFPAWLAPIQVVGIPVTGEHVSYLEEVAAQLKSCGVRTEVDVSDDRMAKKIVR FT HTNQKVPFMLLAGDRDVRTGSVSFRFGDRTQINGVARDSAVEAIVCWIVDRENDFPTAE FT LVKVTGGE" FT misc_feature complement(211767..212945) FT /note="Pfam match to entry PF00587 tRNA-synt_2b, tRNA FT synthetase class II (G, H, P, S and T), score 245.80, FT E-value 5.8e-70" FT misc_feature complement(212046..212075) FT /note="PS00339 Aminoacyl-transfer RNA synthetases class-II FT signature 2" FT misc_feature complement(212472..212537) FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT CDS complement(213908..214313) FT /pseudo FT /transl_table=11 FT /gene="ML0457" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT Rv0356c (Best blastx score 97)" FT CDS complement(214363..215268) FT /transl_table=11 FT /gene="ML0458" FT /product="putative oxidoreductase" FT /note="Similar to putative oxidoreductases from both FT bacteria and eukaryotes e.g. Schizosaccharomyces pombe FT SPBC215.11C, putative aldo-keto reductase, TR:O94315 FT (EMBL:AL033534) (306 aa); Fasta score E(): 0, 53.5% FT identity in 288 aa overlap. Previously sequenced as FT TR:O07152 (EMBL:Z96801) (306 aa); Fasta score E(): 0, FT 100.0% identity in 301 aa overlap. Contains 2 Pfam matches FT to entry PF00248 aldo_ket_red, Aldo/keto reductase family." FT /db_xref="GOA:Q9CCT9" FT /db_xref="HSSP:1HW6" FT /db_xref="InterPro:IPR020471" FT /db_xref="UniProtKB/TrEMBL:Q9CCT9" FT /protein_id="CAC29966.1" FT /translation="MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLT FT GKGVWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEALHPYKGLVIATK FT AGLLRTGRDVWIPLGNPSYLRQELEMSLRRLNVDTIDLFQLHRIDPNFPLADQVGELFT FT LKNEGKIRHIGLSEINLDQLTAAQQITEIVSVQNMYNLSARAAEPLLDAVTSRGIGFIP FT WSPLAAGPLAAPDGPLQRIAVNHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVA FT AAEISLSDDEFEMLSAAGAQ" FT misc_feature complement(214378..214602) FT /note="Pfam match to entry PF00248 aldo_ket_red, Aldo/keto FT reductase family, score 14.70, E-value 0.0036" FT misc_feature complement(214741..214779) FT /note="Pfam match to entry PF00248 aldo_ket_red, Aldo/keto FT reductase family, score 1.00, E-value 28" FT CDS 215293..215666 FT /pseudo FT /transl_table=11 FT /gene="ML0459" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2616 (Best blastx score 154)" FT CDS complement(215771..215989) FT /pseudo FT /transl_table=11 FT /gene="ML0460" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2617c (Best blastx score 163)" FT CDS 216205..216551 FT /pseudo FT /transl_table=11 FT /gene="ML0461" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2618 (Best blastx score 222)" FT CDS complement(217078..217563) FT /pseudo FT /transl_table=11 FT /gene="ML0462" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT Rv0021c (Best blastx score 169)" FT CDS complement(217579..217828) FT /pseudo FT /transl_table=11 FT /gene="ML0463" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT Rv2619c (Best blastx score 147)" FT CDS 217808..218095 FT /transl_table=11 FT /gene="ML0464" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O07155 FT (EMBL:Z96801) (110 aa); Fasta score E(): 0, 100.0% identity FT in 95 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCT8" FT /protein_id="CAC29972.1" FT /translation="MSTVDGVCDEDIYYYYDCIYCAADVASPTGYLPGGLFSLAKLLVI FT RGEKQYVFGLNDSTSVGPGPGNMPWLDDPGLSAVIASSVAAAELAAARSW" FT CDS 218650..219430 FT /pseudo FT /transl_table=11 FT /gene="ML0465" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1320c (Best blastx score 85)" FT CDS 219632..220537 FT /transl_table=11 FT /gene="ML0466" FT /product="possible secreted protein" FT /note="Similar to Streptomyces coelicolor SC6A5.23, FT hypothetical protein, TR:Q9X7W9 (EMBL:AL049485) (261 aa); FT Fasta score E(): 9.5e-26, 36.4% identity in 253 aa overlap. FT Previously sequenced as TR:O07156 (EMBL:Z96801) (301 aa); FT Fasta score E(): 0, 99.7% identity in 301 aa overlap. FT Contains a possible N-terminal signal sequence." FT /db_xref="GOA:O07156" FT /db_xref="InterPro:IPR013831" FT /db_xref="UniProtKB/TrEMBL:O07156" FT /protein_id="CAC29974.1" FT /translation="METFRLGLAAATAASIWAMLNQPGDAISLGSVVDGYTRFTRYVAI FT GDSQTEGLWEGDDTVGLLGFADRLAALVDAVYPGLVYANLAIRGKLLADVLTEQVPQVL FT AMRPDLITVCAGMNDVIQPGRSFARALADLESMYAALAESGATIVTTTFPNVVQFLPLG FT RLVARRLLRINNAITAAADRYEFKLVDLYNAASMRDSATWDIDRVHASTKGHILFAAAV FT AEALNLPNSSHDWAEASGNHAQVPFGVRSYEQLRWMREIFMPWVWRWLRGKSSADGRVP FT KRPRLEPVSASHVEHHDAPT" FT CDS 220583..221227 FT /transl_table=11 FT /gene="dedA" FT /gene_synonym="ML0467" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis dedA, Rv2637, dedA-family FT protein, SW:YQ37_MYCTU (P71936) (218 aa); Fasta score E(): FT 0, 82.8% identity in 209 aa overlap. Similar to many FT dedA-family hypothetical proteins. Previously sequenced as FT SW:YQ37_MYCLE (Q49642) (214 aa); Fasta score E(): 0, 100.0% FT identity in 214 aa overlap. Contains hydrophobic, possible FT membrane-spanning regions. Contains Pfam match to entry FT PF00597 DedA, DedA family." FT /db_xref="GOA:Q49642" FT /db_xref="InterPro:IPR015414" FT /db_xref="UniProtKB/Swiss-Prot:Q49642" FT /protein_id="CAC29975.1" FT /translation="MDVDALLQSIPPLAVYLLVSGVVGVESLGIPLPGEVVLVSAALLS FT SRHDLAVSSIGVGVVAVIGAAVGDSIGYAIGRRFGMPLFDHLGRRFPKHFGPGHVALVE FT RLFNRWGVRAVFFGRFIALLRILAGPLAGALKMHYPRFLAANVSGAICWAGGTTALVYF FT AGMAAERWMERFSWIALIITVVVGIIAAILLRERTSRIIAELEMEYKNRRH" FT misc_feature 220634..221119 FT /note="Pfam match to entry PF00597 DedA, DedA family, score FT 48.10, E-value 2e-10" FT CDS complement(222057..222839) FT /transl_table=11 FT /gene="ML0468" FT /product="putative membrane protein" FT /note="Similar to bacterial hypothetical proteins e.g. FT Aeropyrum pernix APE0183, hypothetical protein, TR:Q9YFR6 FT (EMBL:AP000058) (270 aa); Fasta score E(): 7.2e-07, 26.2% FT identity in 256 aa overlap. Contains hydrophobic, possible FT membrane-spanning regions." FT /db_xref="GOA:Q49657" FT /db_xref="InterPro:IPR002781" FT /db_xref="UniProtKB/TrEMBL:Q49657" FT /protein_id="CAC29976.1" FT /translation="MLVSHLATIGLAGFGAGAINALVGSGTLITFPTLVALGYSPVTST FT MSNAVGLVAGGVSATWGYRAELGDRWSRLRWQIPMSLTGAALGAFLLLHLPEKVFTAIV FT PMLLVLALVLVVAGPRIQSWTRCRAKAAVNRAEHTTPAQMAMLALGTFAVSVYGGYFTA FT GQGILLVSLMSILLPESMQRINAAKNLLSMLVNLTAAVGYTLVAFDRINWSAAGMIAAS FT SLVGGLVGTRYARRLSPNVLRATIVAIGLIGLVRLLAV" FT CDS 223986..225438 FT /pseudo FT /transl_table=11 FT /gene="ML0469" FT /product="acyl-CoA synthase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT fadD13 (Best blastx score 97)" FT CDS complement(227603..227893) FT /transl_table=11 FT /gene="ML0470" FT /product="hypothetical protein" FT /note="Unknown function. Previously sequenced as TR:O07161 FT (EMBL:Z96801) (96 aa); Fasta score E(): 0, 100.0% identity FT in 96 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O07161" FT /protein_id="CAC29978.1" FT /translation="MVQFVARFVVSSCVEIYRQPDILVKCKSVKQGLNNGSFSRWLINE FT QGELQWRASLEISKDKVSKFWFHLTVPNDAITSANQFYGINSNVEKIYRSG" FT CDS 229279..229918 FT /pseudo FT /transl_table=11 FT /gene="ML0471" FT /product="ferrous iron transport protein (pseudogene)" FT /note="Possible ferrous iron transport protein pseudogene" FT CDS 230032..230274 FT /transl_table=11 FT /gene="ML0472" FT /product="hypothetical protein" FT /note="Improbable CDS suggested by GC frameplot and codon FT usage plots. Possibly the remains of a disrupted gene." FT /db_xref="UniProtKB/TrEMBL:Q9CCT7" FT /protein_id="CAC29980.1" FT /translation="MFKLLGFGWLTDVGLFGYLAAWEVFVSILGEVVAATNPDELLEAL FT ATITDDQWYREFTASTVIALLAYFNSPCSACRPLL" FT CDS 230538..230810 FT /transl_table=11 FT /gene="ML0473" FT /product="hypothetical protein" FT /note="Improbable CDS suggested by GC frameplot and codon FT usage plots. Possibly the remains of a disrupted gene." FT /db_xref="UniProtKB/TrEMBL:Q9CCT6" FT /protein_id="CAC29981.1" FT /translation="MRTVDVLITLSIGSSWSELGDQVQDALAEALLHPATWWADVVTDD FT FANLAEISSKLLMGLIGALAESHVGSVELVSLAWSQFGGSDVWYL" FT CDS 231469..232140 FT /transl_table=11 FT /gene="ML0474" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2604c, conserved FT hypothetical protein, TR:O06210 (EMBL:AL123456) (198 aa); FT Fasta score E(): 0, 82.8% identity in 198 aa overlap. FT Similar to many bacterial hypothetical proteins. Shows weak FT similarity to amidotransferases e.g. Streptomyces FT coelicolor hisH, amidotransferase from histidine FT biosynthetic pathway, SW:HIS5_STRCO (P16249) (213 aa); FT BlastP Expect 9.8. Previously sequenced as TR:Q49637 FT (EMBL:U00011) (219 aa); Fasta score E(): 0, 100.0% identity FT in 219 aa overlap. Contains Pfam match to entry PF01174 FT UPF0030, Uncharacterized protein family UPF0030." FT /db_xref="GOA:Q9CCT5" FT /db_xref="HSSP:1R9G" FT /db_xref="InterPro:IPR002161" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCT5" FT /protein_id="CAC29982.1" FT /translation="MAAVMQEGLIRFPAGYPADSAVERVVSFPRVGVLALQGDTREHLT FT ALREAGADSMPVRRRGELDEVDALVIPGGESTTISHLLLDCELLEPLRARLADGLPAYG FT ACTGMILLASEILDAGVCGREALPLGAIDITVRRNAFGRQVDSFEGDIGFAGLVDPVRA FT VFIRAPWVERAGDGVQVLAQAAGHAVAVRQGSMLATAFHPEMTSDRRIHQLFVDIVNGI FT A" FT misc_feature 231565..232131 FT /note="Pfam match to entry PF01174 UPF0030, Uncharacterized FT protein family UPF0030, score 244.20, E-value 1.8e-69" FT CDS 232361..233116 FT /transl_table=11 FT /gene="ML0475" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2603c, conserved FT hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); FT Fasta score E(): 0, 92.4% identity in 251 aa overlap . FT Similar to many bacterial hypothetical proteins. Previously FT sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score FT E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam FT match to entry PF01709 DUF28, Domain of unknown function." FT /db_xref="HSSP:1KON" FT /db_xref="InterPro:IPR017856" FT /db_xref="UniProtKB/Swiss-Prot:Q49645" FT /protein_id="CAC29983.1" FT /translation="MSGHSKWATTKHKKAVIDARRGKMFARLIKNIEVAARVGGGDPVG FT NPTLYDAIQKAKKSSVPNGNIERARKRGAGEEVGGADWQVITYEGYAPNGVAVLIECLT FT DNRNRAAGEVRVAMTRNGGAMADPGSVAYLFSRKGVVTLEKNGLTEDDVLAAVLDAGAE FT EVNDLGDSFEVIAEPGDLVAVRTALQDAGIDYESAEASFQPSVSMPVDLDGARKVFKLV FT DALEDSDDVHNVWTNADVSDEVLAALDGE" FT misc_feature 232373..233077 FT /note="Pfam match to entry PF01709 DUF28, Domain of unknown FT function, score 446.90, E-value 1.7e-130" FT CDS complement(233202..235167) FT /pseudo FT /transl_table=11 FT /gene="speE" FT /gene_synonym="ML0476" FT /product="spermidine synthase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT speE, interrupted by insertion of an RLEP repeat (Best FT blastx score 229)" FT repeat_region 233796..234589 FT /note="Dispersed repeat, RLEP, copy 8" FT CDS complement(235203..235570) FT /pseudo FT /transl_table=11 FT /gene="ML0477" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2600 (Best blastx score 202)" FT CDS complement(235687..236079) FT /pseudo FT /transl_table=11 FT /gene="ML0478" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2599 (Best blastx score 115)" FT CDS complement(236137..236325) FT /pseudo FT /transl_table=11 FT /gene="ML0479" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2598 (Best blastx score 204)" FT CDS complement(236453..237050) FT /pseudo FT /transl_table=11 FT /gene="ML0480" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2597 (Best blastx score 175)" FT CDS 237224..237790 FT /transl_table=11 FT /gene="ruvC" FT /gene_synonym="ML0481" FT /product="crossover junction endodeoxyribonuclease" FT /EC_number="3.1.22.4" FT /note="Similar to M. tuberculosis ruvC, Rv2594c, crossover FT junction endodeoxyribonuclease, SW:RUVC_MYCTU (Q50627) (188 FT aa); Fasta score E(): 0, 81.5% identity in 184 aa overlap. FT Similar to many e.g. Pseudomonas aeruginosa ruvC, crossover FT junction endodeoxyribonuclease, SW:RUVC_PSEAE (Q51424) (174 FT aa); Fasta score E(): 3.2e-15, 37.8% identity in 172 aa FT overlap. Previously sequenced as SW:RUVC_MYCLE (P40834) FT (188 aa); Fasta score E(): 0, 100.0% identity in 188 aa FT overlap. Contains Pfam match to entry PF02075 RuvC, FT Crossover junction endodeoxyribonuclease RuvC. Contains FT PS01321 Crossover junction endodeoxyribonuclease ruvC FT signature. Contains PS00572 Glycosyl hydrolases family 1 FT active site." FT /db_xref="GOA:P40834" FT /db_xref="HSSP:1HJR" FT /db_xref="InterPro:IPR002176" FT /db_xref="UniProtKB/Swiss-Prot:P40834" FT /protein_id="CAC29989.1" FT /translation="MRVMGVDPGLTRCGLSVVENGRGSQVVALDVDVVRTPSDAPVSKR FT LLAVSDVVEHWLDAHHPDVMAIERVFSQQNVSTVMGTAQAGGVIALAAARRGIDVHFHT FT PSEVKAAVTGNGAANKAQVTAMVTRILALQAKPTPADAADALALAICHCWRAPMIARMA FT EAEALGARHRQAYRAKVAGEVKATR" FT misc_feature 237230..237679 FT /note="Pfam match to entry PF02075 RuvC, Crossover junction FT endodeoxyribonuclease RuvC, score 325.40, E-value 6.7e-94" FT misc_feature 237266..237292 FT /note="PS00572 Glycosyl hydrolases family 1 active site" FT misc_feature 237563..237670 FT /note="PS01321 Crossover junction endodeoxyribonuclease FT ruvC signature" FT CDS 237787..238398 FT /transl_table=11 FT /gene="ruvA" FT /gene_synonym="ML0482" FT /product="Holliday junction DNA helicase component" FT /note="Similar to M. tuberculosis ruvA, Rv2593c, Holliday FT junction DNA helicase, SW:RUVA_MYCTU (Q50628) (196 aa); FT Fasta score E(): 0, 76.4% identity in 203 aa overlap. FT Similar to many e.g. Escherichia coli ruvA, Holliday FT junction DNA helicase, SW:RUVA_ECOLI (P08576) (203 aa); FT Fasta score E(): 7e-14, 32.7% identity in 205 aa overlap. FT Previously sequenced as SW:RUVA_MYCLE (P40832) (203 aa); FT Fasta score E(): 0, 99.5% identity in 203 aa overlap. FT Contains Pfam match to entry PF01330 RuvA, Bacterial DNA FT recombination protein, RuvA." FT /db_xref="GOA:P40832" FT /db_xref="InterPro:IPR000085" FT /db_xref="PDB:1BVS" FT /db_xref="UniProtKB/Swiss-Prot:P40832" FT /protein_id="CAC29990.1" FT /translation="MIFSVRGEVLEVALDHAVIEAAGIGYRVNATPSALATLRQGSQAR FT LVTAMVVREDSMTLYGFSDAENRDLFLALLSVSGVGPRLAMATLAVHDAAALRQALADS FT DVASLTRVPGIGKRGAERIVLELRDKVGPVGASGLTVGTAADGNAVRGSVVEALVGLGF FT AAKQAEEATDQVLDGELGKDGAVATSSALRAALSLLGKTR" FT misc_feature 237820..238386 FT /note="Pfam match to entry PF01330 RuvA, Bacterial DNA FT recombination protein, RuvA, score 319.80, E-value 3.2e-92" FT CDS 238395..239444 FT /transl_table=11 FT /gene="ruvB" FT /gene_synonym="ML0483" FT /product="Holliday junction helicase component" FT /note="Similar to M. tuberculosis ruvB, Rv2592c, Holliday FT junction DNA helicase, SW:RUVB_MYCTU (Q50629) (344 aa); FT Fasta score E(): 0, 94.4% identity in 342 aa overlap. FT Similar to many e.g. Escherichia coli ruvB, Holliday FT junction DNA helicase, SW:RUVB_ECOLI (P08577) (336 aa); FT Fasta score E(): 0, 54.1% identity in 329 aa overlap. FT Previously sequenced as SW:RUVB_MYCLE (P40833) (369 aa); FT Fasta score E(): 0, 100.0% identity in 322 aa overlap. FT Contains Pfam match to entry PF00004 AAA, ATPases FT associated with various cellular activities (AAA). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /db_xref="GOA:P40833" FT /db_xref="HSSP:1IN4" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P40833" FT /protein_id="CAC29991.1" FT /translation="MSEDYLDRDVSPALTVGEADIDVSLRPRSLREFIGQPRVREQLQL FT VIEGAKNRGATPDHILLSGPPGLGKTSLAMIIAAELGSSLRMTSGPALERAGDLAVMLS FT NLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVIVGKGPGATSIPLEVAPFTLVGAT FT TRSGALTGPLRDRFGFTAHMDFYEPTELEGVLARAAGILGIELGVEAGAEIARRSRGTP FT RIANRLLRRVRDFAEVRADGVITRDVAKAALAVYDVDELGLDRLDRAVLSALTRSFGGG FT PVGVSTLAVAVGEEATTVEEVCEPFLVRAGMVARTPRGRVATAQAWTYLCMTPPVGVTG FT LSQPGLFES" FT misc_feature 238569..239156 FT /note="Pfam match to entry PF00004 AAA, ATPases associated FT with various cellular activities (AAA), score -14.30, FT E-value 0.00034" FT misc_feature 238584..238607 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(240381..243947) FT /transl_table=11 FT /gene="fadD9" FT /gene_synonym="ML0484" FT /product="putative acyl-CoA synthetase" FT /note="Similar to M. tuberculosis fadD9, Rv2590, putative FT acyl-CoA synthetase, TR:Q5063 (EMBL:Al123456) (1168 aa); FT Fasta score E(): 0, 68.0% identity in 1178 aa overlap1. FT Similar to acyl-CoA ligases and to domains of FT polyketide/peptide synthetases e.g. Mycobacterium smegmatis FT mps, peptide synthetase, TR:Q9RLP6 (EMBL:AJ238027) (5990 FT aa); Fasta score E(): 0, 37.2% identity in 1168 aa overlap. FT C-terminal half is similar to eukaryotic FT aminoadipate-semialdehyde dehydrogenase e.g. Saccharomyces FT cerevisiae lys2, aminoadipate-semialdehyde dehydrogenase FT large subunit, SW:LYS2_YEAST (P07702) (1392 aa); Fasta FT score E(): 7.1e-18, 25.1% identity in 734 aa overlap. FT Previously sequenced as TR:O69484 (EMBL:AL023591) (1174 FT aa); Fasta score E(): 0, 100.0% identity in 1174 aa FT overlap. Contains Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site. Contains Pfam match to FT entry PF00501 AMP-binding, AMP-binding enzyme. Contains FT PS00455 Putative AMP-binding domain signature. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature." FT /db_xref="GOA:Q9CCT4" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CCT4" FT /protein_id="CAC29992.1" FT /translation="MWRQQSISHRKESVMSTITKQEKQLARRVDDLTANDPQFAAAKPD FT PAVAAALAQPGLRLPQIIQTALDGYAERPALGQRVAEFTKDPKTGRTSMELLPSFETIT FT YRQLGDRVGALARAWRHDLLHAGYRVCVLGFNSVDYAIIDMALGVIGAVAVPLQTSAAI FT TQLQSIVTETEPSMIATSVNQLPDTVELILSGQAPAKLVVFDYHPEVDEQHDAVATARA FT RLADSSVVVESLTEVLGRGKTLPATPIPVADDSADPLALLIYTSGSTGAPKGAMYLQSN FT VGKMWRRSDGNWFGPTAASITLNFMPMSHVMGRGILYGTLGNGGTAYFAARSDLSTLLE FT DLKLVRPTELNFVPRIWETLYDESKRAVDRRLANSGSADRAAIKAEVMDEQRQSLLGGR FT YIAAMTGSAPTSPELKHGVESLLEMHLLEGYGSTEAGMVLFDGEVQRPPVIDYKLVDVP FT DLGYFSTDQPYPRGELLLKTQNMFPGYYKRPEVTATVFDSDGYYQTGDIVAEVGPDRLV FT YVDRRNNVLKLAQGQFVTVAKLEAAFSNSPLVRQIYIYGNSAHPYLLAVVVPTEDALAT FT NDIEVLKPLIIDSLQKVAKEADLQSYEVPRDLIVETTPFSLENGLLTGIRKLAWPKLKQ FT HYGARLEQLYADLVEGQANALHVLKQSVANAPVLQTVSRAVGTILGVATTDLPSNAHFT FT DLGGDSLSALTFGSLLRELFDIDVPVGVIVSPVNNLVAIADYIERERQGTKRPTFIAIH FT GRDAGKVHASDLTLDKFIDVSTLTAAPVLAQPGTEVRTVLLTGATGFLGRYLALKWLER FT MDLVEGKVIALVRAKSNEDARARLDKTFDSGDPKLLAHYQELATDHLEVIAGDKGEVDL FT ELDRQTWRRLADTVDLIVDPAALVNHVLPYSELFGPNTLGTAELIRIALTSKQKPYIYV FT STIGVGNQIEPAKFTEDSDIRVISPTRNINNNYANGYGNSKWAGEVLLREAHDLCGLPV FT TVFRCDMILADTSYAGQLNVPDMFTRMMLSLAATGIAPGSFYELDAESNRQRAHYDGLP FT VEFIAEAISTLGDQSLHDRDGFTTYHVMNPHDDGIGMDEFVDWLIDAGCPIQRINDYDE FT WLRRFEISLRALPERQRHSSLLPLLHNYQKPEKPLHGSLAPTIRFRTAVQNANIGQDKD FT IPHISPAIIAKYVSDLQLLGLV" FT misc_feature complement(241002..241088) FT /note="PS00061 Short-chain dehydrogenases/reductases family FT signature" FT misc_feature complement(241779..241940) FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 33.60, E-value FT 1.2e-07" FT misc_feature complement(242286..243638) FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score -100.90, E-value 8.7e-10" FT misc_feature complement(243129..243164) FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(244043..245383) FT /transl_table=11 FT /gene="gabT" FT /gene_synonym="ML0485" FT /product="putative 4-aminobutyrate aminotransferase" FT /EC_number="2.6.1.19" FT /note="Similar to M. tuberculosis gabT, Rv2589, FT 4-aminobutyrate aminotransferase, SW:GABT_MYCTU (Q50632) FT (449 aa); Fasta score E(): 0, 83.7% identity in 449 aa FT overlap. Similar to many e.g. Escherichia coli gabT, FT 4-aminobutyrate aminotransferase, SW:GABT_ECOLI (P22256) FT (426 aa); Fasta score E(): 0, 43.1% identity in 422 aa FT overlap. Previously sequenced as SW:GABT_MYCLE (P40829) FT (446 aa); Fasta score E(): 0, 99.8% identity in 446 aa FT overlap. Contains Pfam match to entry PF00202 aminotran_3, FT Aminotransferases class-III pyridoxal-phosphate. Contains FT PS00600 Aminotransferases class-III pyridoxal-phosphate FT attachment site." FT /note="Similar to ML1216, ML1409 and ML2414" FT /db_xref="GOA:P40829" FT /db_xref="HSSP:1QJ3" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/Swiss-Prot:P40829" FT /protein_id="CAC29993.1" FT /translation="MTSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRA FT AGGVIEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRAQVADFTHTCFIITPYEEYVAV FT TEQLNRITPGSGEKRSVLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLTMAL FT TAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADD FT LAAVIIEPIQGEGGFIVPAEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDG FT IVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSGLGGTFGGNPVACAAALATITTIEN FT DGLIQRAQQIERLITDRLLRLQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVA FT TAAHATGVIILTCGMFGNIIRLLPPLTISDELLAEGLDILSRILGDF" FT misc_feature complement(244109..245245) FT /note="Pfam match to entry PF00202 aminotran_3, FT Aminotransferases class-III pyridoxal-phosphate, score FT 639.30, E-value 7.7e-222" FT misc_feature complement(244496..244609) FT /note="PS00600 Aminotransferases class-III FT pyridoxal-phosphate attachment site" FT RBS complement(245390..245395) FT /note="possible RBS" FT CDS 245652..245996 FT /transl_table=11 FT /gene="ML0486" FT /product="putative secreted protein" FT /note="Similar to M. tuberculosis Rv2588c, hypothetical FT protein, SW:YP88_MYCTU (Q50633) (115 aa); Fasta score E(): FT 7e-29, 77.0% identity in 100 aa overlap. Similar to FT bacterial hypothetical proteins e.g. Streptomyces FT coelicolor SCL2.07C, putative secreted protein, TR:CAB70919 FT (EMBL:AL137778) (169 aa); Fasta score E(): 7.3e-08, 35.8% FT identity in 120 aa overlap. Previously sequenced as FT SW:YP88_MYCLE (Q49647) (114 aa); Fasta score E(): 0, 100.0% FT identity in 114 aa overlap. Contains a possible N-terminal FT signal sequence." FT /db_xref="GOA:Q49647" FT /db_xref="InterPro:IPR003849" FT /db_xref="UniProtKB/Swiss-Prot:Q49647" FT /protein_id="CAC29994.1" FT /translation="MESLVLLLLFLLIMGGFMFFASRRQRRSMQATIDLYNSLQPGDRV FT NTTSGLQATIIVVGDDTVDLEIAPGVVTTWMKLAIRDRILPDDAYMDEHEAEPGDFVYC FT DELEESDGSS" FT CDS 246036..247829 FT /transl_table=11 FT /gene="secD" FT /gene_synonym="ML0487" FT /product="putative protein-export membrane protein" FT /note="Similar to M. tuberculosis secD, Rv2587c, putative FT protein-export membrane protein, SW:SECD_MYCTU (Q50634) FT (573 aa); Fasta score E(): 0, 80.6% identity in 583 aa FT overlap. C-terminal half is similar to the corresponding FT region of Escherichia coli secD, protein-export membrane FT protein, SW:SECD_ECOLI (P19673) (689 aa); BlastP Expect FT 0.42. Shows full length similarity to M. tuberculosis and FT Streptomyces coelicolor homolgues. Previously sequenced as FT SW:SECD_MYCLE (P38387) (571 aa); Fasta score E(): 0, 99.8% FT identity in 571 aa overlap. Contains hydrophobic, possible FT membrane-spanning regions." FT /db_xref="GOA:P38387" FT /db_xref="InterPro:IPR003335" FT /db_xref="UniProtKB/Swiss-Prot:P38387" FT /protein_id="CAC29995.1" FT /translation="MSCVKGLVMRHVGSVGKNRFRGDTRNVASSSAPVHFGRYLSMFLV FT LFIGVYLLAFLTGDKRVVPRLGIDLQGGTRVTLTARTPDGSRPSREALSQAQQIISSRV FT NGLGVSGSEVVVDGDNLVITVPGNDGNEARNLGQTARLYIRPVLNSLPVQRGQDPKPGS FT PAGTLPNFAPMPPDHPGAQPRPYLQDPTSSPSSDPMPSPVPTGAALPGEVPSVEQPAPP FT DPRKDLAERIAEEKKWRQSTKQSIQFLALQFESTHCDKDDILAGNDDPNLPLATCSTDH FT NMAYLLAPSIISGDQIQNSTSGMNQRGVGYVVDLQFKSAAADVWADFTAAHIGTQTAFT FT LDSEVVSVPVINEAILGGRTQISGGDPPFTAATARQLANVLKYGSLPLSFEPSEAQTVS FT ATLGLTSLRAGLIAGAIGLSLVLLYSLLYYRVLGLLTAFSLFCSGTIIFAILVLLGRYI FT NYTLDLAGIAGLIIGIGTTADSFVVFFERIKDEIREGRSFRSAVPRGWVRARKTIVSGN FT AVTFLAAAVLHFLAIGQVKGFAFTLGLTTILDLVVVFLVTWPLVYLASKSPLLARPAYN FT GLGAVQQVARERRASAKTGRG" FT RBS 247817..247822 FT /note="possible RBS" FT CDS 247834..249249 FT /transl_table=11 FT /gene="secF" FT /gene_synonym="ML0488" FT /product="putative protein-export membrane protein" FT /note="Similar to M. tuberculosis secF, Rv2586c, putative FT protein-export membrane protein, SW:SECF_MYCTU (Q50635) FT (442 aa); Fasta score E(): 0, 72.1% identity in 456 aa FT overlap. Similar to Escherichia coli secF, protein-export FT membrane protein, SW:SECF_ECOLI (P19674) (189 aa); BlastP FT Expect 8.5. Previously sequenced as SW:SECF_MYCLE (P38386) FT (394 aa); Fasta score E(): 0, 99.7% identity in 394 aa FT overlap. Contains hydrophobic, possible membrane-spanning FT regions." FT /db_xref="GOA:P38386" FT /db_xref="InterPro:IPR005665" FT /db_xref="UniProtKB/Swiss-Prot:P38386" FT /protein_id="CAC29996.1" FT /translation="MVSRAKVGAETTKGIDEPDRNDNTDDNGAGAVEVTEAAEDAVELT FT NDISTQLPQHGFLARFYTGLSRLYTGTGVFEVVGRRRLWYSVGGVIVAVAVLSIIVRGF FT TFGIDFKGGTTVSMPVSPGVGGTGAIEVAQVADVFKKTLGSDPESVVVVGNGASATVRI FT SSKTLSNDQTSKLRNALFDAFGPKGADAKPSKQAISDAAVSETWGGQITKKVVIALVVF FT LVLVGLYITVRYERYMAISALTTMCFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLY FT DTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTSLISVLPVLALMVVAVW FT LLGVGTLKDLALVQLVGIIVGTYSSIFFATPLLVTLRERTELVRTHTRRVVKRRTLGSQ FT VGKKNADSHVAAGTRKPQNQAESCADASSQEGTEVATASVPTVLSKLAPGVRPVRPTGT FT RRPTGKRNNVGRR" FT CDS 249294..250961 FT /transl_table=11 FT /gene="ML0489" FT /product="putative lipoprotein" FT /note="Similar to M. tuberculosis Rv2585c, hypothetical FT protein, SW:YP85_MYCTU (Q50636) (557 aa); Fasta score E(): FT 0, 78.9% identity in 546 aa overlap. Previously sequenced FT as SW:YP85_MYCLE (Q49646) (426 aa); Fasta score E(): 0, FT 98.8% identity in 332 aa overlap. Contains a probable FT N-terminal signal sequence. Contains PS00013 Prokaryotic FT membrane lipoprotein lipid attachment site." FT /db_xref="GOA:Q49646" FT /db_xref="InterPro:IPR000914" FT /db_xref="UniProtKB/Swiss-Prot:Q49646" FT /protein_id="CAC29997.1" FT /translation="MRSGLFGVLRWTAVGLVATLVASLALTACSGSAAGEIVYVVDGAL FT GTYNTNTIVGAASAGAQAFARTLIGFGYHGPDGQIVADHDFGTITVVGGVPLVLDYQIA FT DNAVYSDGKQVTCDDLVLTWAAQSGRFPGFDAATQAGYRDIANIECLAGQKKSRVFFVP FT DRSVVDYEQLFAATSMMPSHVIADQLNIDVTEALLTHNATLVEQIARLWNTTWDLKPAV FT DLRRFPSSGPYKIESVLNGGAVVLVANDRWWGLKATTKRITVRPQEADIQDRVNNRSVD FT VVDVAVGSSGSLATPDNYARIDSPSAGIEQLIFAPQGLLAAAAARRALALCTPRDVVAR FT DAGLSIANSRLSPATEDAIAAADGAREAGQFSKADPAAAHDALSGETLPVRIGYQGPNA FT RLAATVGTIAKACAVAGISVSSVTLDSSTDPSGPQALRDGKIDVLLASTGGATGSGSSG FT SSSMDAYDLHTGNGNNLSGYANAQVDNNIGALAVSADPAERVRLLADSAPVLWADMPTL FT PLYRQQRMLLMSKTMYAVTRNPTRWGAGWNMDRWALVR" FT misc_feature 249348..249380 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 250985..251504 FT /pseudo FT /transl_table=11 FT /gene="apt" FT /gene_synonym="ML0490" FT /product="adenine phosphoribosyltransferases (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT apt (Best blastx score 222)" FT RBS 251594..251600 FT /note="possible RBS" FT CDS 251607..253970 FT /transl_table=11 FT /gene="relA" FT /gene_synonym="ML0491" FT /product="putative GTP pyrophosphokinase" FT /EC_number="2.7.6.5" FT /note="Similar to M. tuberculosis relA, Rv2583c, putative FT GTP pyrophosphokinase, SW:RELA_MYCTU (Q50638) (790 aa); FT Fasta score E(): 0, 93.4% identity in 790 aa overlap. FT Similar to many e.g. Corynebacterium glutamicum relA, GTP FT pyrophosphokinase, SW:RELA_CORGL (O87331) (760 aa); Fasta FT score E(): 0, 66.0% identity in 756 aa overlap. Previously FT sequenced as SW:RELA_MYCLE (Q49640) (787 aa); Fasta score FT E(): 0, 99.9% identity in 787 aa overlap. Contains a FT probable helix-turn-helix motif at aa 41-62 (Score 1005, SD FT +2.61) Contains Pfam match to entry PF01842 ACT, ACT FT domain." FT /db_xref="GOA:Q49640" FT /db_xref="InterPro:IPR004095" FT /db_xref="UniProtKB/Swiss-Prot:Q49640" FT /protein_id="CAC29999.1" FT /translation="MADDQGTAQALQPVQVVPGPAVEAPETPVETLKTSSSASRRVRAR FT LARRMTAQRSTISPVLEPLVAVHKEFYPKANLSIVQRAFEVADQRHASQLRRSGDPYIT FT HPLAVANILAELGMDITTLVAALLHDTVEDTGYTLEALSEEFGDEVGHLVDGVTKLDRV FT VLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIA FT PLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIISTLGA FT SKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIRILCDEIRDCYAAVGVVHSLWQ FT PMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEA FT KGRNGVLHPHAAAEIDDMAWMRQLLDWQREAAEPGEFLESLRYDLAVQEIFVFTPKGDV FT ITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEFVEIFTSKAPNAGPS FT RDWQQFVVSPRAKTKIRQWFAKERREEALEAGKDAMAREVRRGGLPLQRLVNGESMAAV FT ARELHYIDVSALYTAIGEGHVSARHVVQRLLAELGGIDQAEEELAERSTPTTMLRRQRS FT TDDVGVSVPGAPGVLTKLAKCCTPVPGDAIMGFVTRGGGVSVHRTDCTNTASLQQQAER FT IIEVLWAPSSSSVFLVAIQVEALDRHRLLLDITRALADERVDILSASVTTSGDRVAISR FT FTFEMGDPKHLGHLLNVVRNVEGVYDVYRVMSAS" FT misc_feature 253734..253952 FT /note="Pfam match to entry PF01842 ACT, ACT domain, score FT 49.70, E-value 6.3e-11" FT CDS complement(254029..254916) FT /transl_table=11 FT /gene="ppiB" FT /gene_synonym="ML0492" FT /product="putative peptidyl-prolyl cis-trans isomerase" FT /EC_number="5.2.1.8" FT /note="Similar to M. tuberculosis ppiB, Rv2582, putative FT peptidyl-prolyl cis-trans isomerase, SW:CYPB_MYCTU (Q50639) FT (308 aa); Fasta score E(): 0, 72.5% identity in 295 aa FT overlap. Shows weak similarity to part of Caenorhabditis FT elegans cvp-1, peptidyl-prolyl cis-trans isomerase 1, FT SW:CYP1_CAEEL (P52009) (192 aa); Fasta score E(): 0.00071, FT 36.4% identity in 165 aa overlap. Previously sequenced as FT SW:CYPB_MYCLE (P46697) (295 aa); Fasta score E(): 0, 99.7% FT identity in 295 aa overlap. Contains hydrophobic, possible FT membrane-spanning region. Alternatively, this may represent FT an N-terminal signal sequence, given teh potential start FT codon at codon 33. Contains Pfam match to entry PF00160 FT pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans FT isomerase." FT /db_xref="GOA:P46697" FT /db_xref="HSSP:1H0P" FT /db_xref="InterPro:IPR002130" FT /db_xref="UniProtKB/Swiss-Prot:P46697" FT /protein_id="CAC30000.1" FT /translation="MPTNEQRRATAKRKLKRQLERRAKQARWRRVLLISGGVVVAVAVI FT ITVVATVVISKLGHKHDTASSTASNSLTATKTPAVTPSVLPLPSFQPSTNLGVNCQYPP FT SADKAAKPVKPPRAGKVPTDPATVSASMATNQGNIGLLLNNAESPCTVNSFASLTGQGF FT FNNTKCHRLTTSLMLGVLQCGDPKVDGTGGPGYKFANEYPTDQYPPNDPKLKQPVLYPR FT GTLAMANSGPNTNGSQFFLVYHDSQLPPEYTVFGTIQADGLATLDKIAKGGIASGGDDG FT PPATEVTIESLRLD" FT misc_feature complement(254197..254538) FT /note="Pfam match to entry PF00160 pro_isomerase, FT Cyclophilin type peptidyl-prolyl cis-trans isomerase, score FT 42.80, E-value 2.4e-11" FT RBS complement(254927..254931) FT /note="possible RBS" FT CDS 255080..255736 FT /transl_table=11 FT /gene="ML0493" FT /product="putative hydrolase" FT /note="Similar to M. tuberculosis Rv2581c, hypothetical FT protein, SW:YP81_MYCTU (Q50640) (224 aa); Fasta score E(): FT 0, 82.0% identity in 222 aa overlap. Similar to many FT bacterial hypothetical proteins. Previously sequenced as FT SW:YP81_MYCLE (Q49649) (218 aa); Fasta score E(): 0, 99.5% FT identity in 218 aa overlap. Contains Pfam match to entry FT PF00753 lactamase_B, Metallo-beta-lactamase superfamily." FT /note="Similar to ML1391 and ML1912" FT /db_xref="GOA:Q49649" FT /db_xref="InterPro:IPR001279" FT /db_xref="UniProtKB/Swiss-Prot:Q49649" FT /protein_id="CAC30001.1" FT /translation="MLITGFPAGMLQCNCYVLADRAGTDAVIVDPGQRAMGPLRRILDE FT NRLTPSAVLLTHGHIDHMWSAQKVSDTYGCPTYIHPEDRFMLTDPLFGFGPRVAQVVTG FT AFFREPKQVVELDRDGDKLDLGSVTVNVDHTPGHTRGSVCFWVAADTDVVLTGDTLFER FT TIGRTDLFGGSGRDLYRSIVEKLLVLDDKTVVLPGHGNSTTIGAERRFNPFLEGL" FT misc_feature 255101..255676 FT /note="Pfam match to entry PF00753 lactamase_B, FT Metallo-beta-lactamase superfamily, score 169.30, E-value FT 6.3e-47" FT CDS 255740..257023 FT /transl_table=11 FT /gene="hisS" FT /gene_synonym="ML0494" FT /product="histidyl-tRNA synthase" FT /EC_number="6.1.1.21" FT /note="Similar to M. tuberculosis hisS, Rv2580c, FT histidyl-tRNA synthase, SW:SYH_MYCTU (Q50641) (423 aa); FT Fasta score E(): 0, 85.9% identity in 417 aa overlap. FT Similar to many e.g. Escherichia coli hisS, histidyl-tRNA FT synthase, SW:SYH_ECOLI (P04804) (423 aa); Fasta score E(): FT 0, 42.1% identity in 413 aa overlap. Previously sequenced FT as SW:SYH_MYCLE (P46696) (427 aa); Fasta score E(): 0, FT 99.5% identity in 427 aa overlap. Contains Pfam match to FT entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, FT P, S and T). Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00211 ABC transporters family FT signature." FT /db_xref="GOA:P46696" FT /db_xref="HSSP:1QE0" FT /db_xref="InterPro:IPR004154" FT /db_xref="UniProtKB/Swiss-Prot:P46696" FT /protein_id="CAC30002.1" FT /translation="MTESCTVFSFSGPKGIPDYFPPDSAQFVAVRDGLLTAARRAGYGD FT IELPVFEDTALFARGVGESTDVVAKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDR FT GALPVKLCYAGPFFRYERPQAGRCRQLQQVGVEAIGVDDPALDAEVITIADAGFRSLGL FT DGFQLEITSLGDGTCRPQYRKLLQEFLLQLDLDEDTRRRAELNPLRVLDDKRPQVQAMT FT AAAPVLLDHLSDGAKQHFDTVLAHLDALRVPYVINPRMVRGLDYYTKTTFEFVHPGLGA FT QSGIGGGGRYDGLMRQLGGQDLSGIGFGLGVDRTLLALHAEGKTVGETTRCDVFGVSLG FT EAAKLKVAMLAGQLRAAGVRVDLIYGDRGIRGAMRAAGRSGARIALIVDDCAIKADGVG FT VRDLATGEQISVAVDSVVAEVISRIAPS" FT misc_feature 255917..256966 FT /note="Pfam match to entry PF00587 tRNA-synt_2b, tRNA FT synthetase class II (G, H, P, S and T), score 292.60, FT E-value 5e-84" FT misc_feature 256691..256714 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 256748..256792 FT /note="PS00211 ABC transporters family signature" FT CDS 257152..257597 FT /pseudo FT /transl_table=11 FT /gene="PE_PGRS" FT /gene_synonym="ML0495" FT /product="PE_PGRS-family protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT PE_PGRS genes (Best blastx score 176)" FT CDS 257750..258325 FT /pseudo FT /transl_table=11 FT /gene="ML0496" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2578c (Best blastx score 339)" FT CDS complement(258342..259849) FT /pseudo FT /transl_table=11 FT /gene="ML0497" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2577 (Best blastx score 414)" FT CDS 260110..260425 FT /pseudo FT /transl_table=11 FT /gene="ML0498" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2576c (Best blastx score 119)" FT CDS complement(261196..262015) FT /pseudo FT /transl_table=11 FT /gene="ML0499" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2575 (Best blastx score 329)" FT CDS complement(262108..262592) FT /pseudo FT /transl_table=11 FT /gene="ML0500" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2573 (Best blastx score 211)" FT RBS 262830..262833 FT /note="possible RBS" FT CDS 262839..264608 FT /transl_table=11 FT /gene="aspS" FT /gene_synonym="ML0501" FT /product="aspartyl-tRNA synthetase" FT /EC_number="6.1.1.12" FT /note="Similar to M. tuberculosis aspS, Rv2572c, FT aspartyl-tRNA synthetase, SW:SYD_MYCTU (Q50649) (596 aa); FT Fasta score E(): 0, 88.0% identity in 592 aa overlap. FT Similar to many e.g. Escherichia coli aspS, aspartyl-tRNA FT synthetase, SW:SYD_ECOLI (P21889) (590 aa); Fasta score FT E(): 0, 46.8% identity in 583 aa overlap. Previously FT sequenced as SW:SYD_MYCLE (P36429) (589 aa); Fasta score FT E(): 0, 99.8% identity in 589 aa overlap. Contains Pfam FT match to entry PF00152 tRNA-synt_2, tRNA synthetases class FT II (D, K and N). Contains PS00179 Aminoacyl-transfer RNA FT synthetases class-II signature 1." FT /db_xref="GOA:P36429" FT /db_xref="HSSP:1L0W" FT /db_xref="InterPro:IPR004365" FT /db_xref="UniProtKB/Swiss-Prot:P36429" FT /protein_id="CAC30009.1" FT /translation="MLRSHGAGVLRKSDAGQQVTLAGWVSRRRDHGGVIFIDLRDSSGI FT TQAVFREPDVLAQAHRLRAEFCIAVSGVVEIRPEGNANAEIPTGDIEVNATSLTVLGES FT APLPFQLDEPAGEELRLKYRYLDLRRDGPGSAIRLRSKVNATARAVLARHDFVEIETPT FT ITRSTPEGARDFLVPARLRPGTFYALPQSPQLFKQLLMVAGMERYYQIAHCYRDEDFRA FT DRQPEFTQLDMEMSFVDAEDVIAISEEILTELWMLIGYHIPAPIPRISYADAMRRFGSD FT KPDLRFGLELVECTEFFCDTTFRVFQAPYVGAVVMPGGAAQPRRTLDEWQDWAKQRGHR FT GLAYVLVTDDGTLGGPVAKNFSDAERSRLASHVGAEPGDCIFFSAGPAKSSRALLGAAR FT GEIANRLGLIDPEAWAFVWVVDPPLFERADEATKVGEMAVGSGAWTAVHHAFTSPKPEF FT EDSIESDPGSVLADAYDIVCNGHEIGSGSVRINRRDIQERVFAVMGLEKAEAEEKFGFL FT LEAFTFGAPPHGGIAFGWDRTNALLAGMESIREVIAFPKTGGGVDPLTDAPASITAQQR FT KESGIDTKPKEVE" FT misc_feature 263184..264515 FT /note="Pfam match to entry PF00152 tRNA-synt_2, tRNA FT synthetases class II (D, K and N), score -4.30, E-value FT 2.1e-11" FT misc_feature 263481..263534 FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT CDS 264647..265029 FT /pseudo FT /transl_table=11 FT /gene="ML0502" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT Rv1558 (Best blastx score 72)" FT CDS 265984..266358 FT /pseudo FT /transl_table=11 FT /gene="PPE" FT /gene_synonym="ML0503" FT /product="PPE-family protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis PPE FT genes (Best blastx score 98)" FT CDS complement(267087..268390) FT /pseudo FT /transl_table=11 FT /gene="ML0504" FT /product="transposase (pseudogene)" FT /note="Possible pseudogene of transposase similar to FT Mycobacterium avium istA (Best blastx score 250)" FT CDS complement(268560..269458) FT /pseudo FT /transl_table=11 FT /gene="ML0505" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2424c (Best blastx score 206)" FT CDS complement(270636..270999) FT /pseudo FT /transl_table=11 FT /gene="ML0506" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT Rv2570 (Best blastx score 169)" FT CDS 271180..273503 FT /pseudo FT /transl_table=11 FT /gene="ML0507" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2567 (Best blastx score 542)" FT CDS 273501..274442 FT /transl_table=11 FT /gene="ML0508" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2569c, conserved FT hypothetical protein, SW:YP69_MYCTU (Q50652) (314 aa); FT Fasta score E(): 0, 84.4% identity in 301 aa overlap and to FT other hypothetical proteins from M. tuberculosis. Contains FT Pfam match to entry PF01841 Transglut_core, FT Transglutaminase-like superfamily." FT /note="Similar to ML0607" FT /db_xref="InterPro:IPR002931" FT /db_xref="UniProtKB/TrEMBL:Q9CCT2" FT /protein_id="CAC30016.1" FT /translation="MLSCHMKWTQLTSRRYRVSHRTEYRYSDVVTSSYGRGFLTPCDSL FT RQRCVDHRLHIVPVPADSSISRDSYGNISSYFHVTEPHCTLTVTSESIVDVYPTPPELF FT TSGPASAPWEAARPTGRRGVLATEFTLDLNPPEITDEVRQYAAPSFEPQRPLIEVLRDL FT TTRIYADFTYRSGSTTISTGVNEVLLAREGVCQDFARLAIACLRANGLAASYVSGYLAT FT DPPPGKDRMVGIDVTHAWASVWTPQQSGQCEWLGLDPTNDQLVDERYIVVGQGRDYVNV FT PPLRGIIYTNSENSVIDVAVDVAPCEGDALYA" FT misc_feature 274068..274280 FT /note="Pfam match to entry PF01841 Transglut_core, FT Transglutaminase-like superfamily, score 80.40, E-value FT 3.6e-20" FT CDS 274435..275450 FT /pseudo FT /transl_table=11 FT /gene="ML0509" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2568c (Best blastx score 271)" FT CDS 275666..277087 FT /transl_table=11 FT /gene="ML0510" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2559c, conserved FT hypothetical protein, SW:YP59_MYCT (Q50739) (452 aa); Fasta FT score E(): 0, 83.4% identity in 452 aa overlapU. Similar to FT many hypothetical proteins in bacteria and eukaryotes e.g. FT Escherichia coli ycaJ, hypothetical protein, SW:YCAJ_ECOLI FT (P45526) (447 aa); Fasta score E(): 0, 42.7% identity in FT 417 aa overlap. Previously sequenced as TR:O69490 FT (EMBL:AL023591) (447 aa); Fasta score E(): 0, 99.8% FT identity in 447 aa overlap. Contains Pfam match to entry FT PF00004 AAA, ATPases associated with various cellular FT activities (AAA). Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /db_xref="GOA:Q9CCT1" FT /db_xref="HSSP:1J7K" FT /db_xref="InterPro:IPR003959" FT /db_xref="UniProtKB/TrEMBL:Q9CCT1" FT /protein_id="CAC30018.1" FT /translation="MGTRWVPESSGFTVTDLSVLRGISNVVSDSLFDLPGAPQPTDYGL FT GGSTGVPLAVRMRPASLDELVGQGHLLAPGSPLRRLVEGSGVVSAILHGPPGCGKTTLA FT ALISQATGHRFEALSALSAGVKDVRAVLKIARSALLSGKRTVLFIDEVHRFSKTQQDAL FT LSAVENRVVLLVAATTENPSFSVVAPLLSRSLILQLRPLNADDIRAVVQRAVDDPRGLG FT GQIAVAPEAVDLLVRLAAGDARRVLTALEVAAEAVQTGDELTVATIEQSLDNAAVRYDR FT DGDQHYDIVSAFIKSVRGSDVDAALHYLARMLIAGEDPRFIARRLLILASEDIGLADST FT ALPLAVAAAQTVQLIGMPEAQLALAHATIHLATAPKSNAVMTALGSAIDDIKAGKAGLV FT PAHLRDGHYSGAAALGNAKGYKYSHDDPDGVVAQQYPPYELVEVDYYRPTGRGGERELV FT GRLDRLRAIIRGRRG" FT misc_feature 275930..276508 FT /note="Pfam match to entry PF00004 AAA, ATPases associated FT with various cellular activities (AAA), score -4.80, FT E-value 6.2e-05" FT misc_feature 275945..275968 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(277128..277842) FT /pseudo FT /transl_table=11 FT /gene="ML0511" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv2558 (Best blastx score 199)" FT CDS 278159..280885 FT /transl_table=11 FT /gene="alaS" FT /gene_synonym="ML0512" FT /product="alanyl-tRNA synthetase" FT /EC_number="6.1.1.7" FT /note="Similar to M. tuberculosis alaS, Rv2555c, FT alanyl-tRNA synthetase, SW:SYA_MYCTU (O07438) (904 aa); FT Fasta score E(): 0, 84.7% identity in 907 aa overlap. FT Similar to many e.g. Homo sapiens aarS, alanyl-tRNA FT synthetase, SW:SYA_HUMAN (P49588) (968 aa); Fasta score FT E(): 0, 35.7% identity in 971 aa overlap. Contains Pfam FT match to entry PF01411 tRNA-synt_2c, tRNA synthetases class FT II (A). Contains PS00339 Aminoacyl-transfer RNA synthetases FT class-II signature 2." FT /db_xref="GOA:Q9CCT0" FT /db_xref="InterPro:IPR012947" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCT0" FT /protein_id="CAC30020.1" FT /translation="MQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQFV FT PFFLGQCTPPYATATSIQKCIRTPDIDDVGITTRHNTFFQMAGNFSFGDYFKRGAIELA FT WALLTNSFADGGYGLDPERLWATVYLDDDEAAGLWQEIAGLPPERIQRRGMADNYWSMG FT IPGPCGPSSEIYYDRGPEFGPEGGPIVNEDRYLEVWNLVFMQNERGEGTTKEDYEIRGP FT LPRKNIDTGMGVERIALVLQGVHNVYEIDLLRPVIDLVATRAPRPYDPENEDTNHADNV FT RYRIIADHSRTAAILIGDGVSPVNDGRGYVLRRLLRRIIRSAKLLGIDSPIVGDLMATV FT CNAMGRAYPGLVTDFDRINRIAVAEETAFNRTLTSGSKLFDDVVGATVASGSTVVAGLD FT AFTLHDTYGFPIELTLEMAAEAGLTVDEKGFHELMLQQRQRAKVDAAARKQAHVDLTAY FT RELVDAGPTEFTGFDELTTEARILGIFVEGKRVPVVAHAVRGQAGITNRVELVLDRTPL FT YAESGGQIADAGTISGIGAGASSRAAVTDVQKIAKTLHVHRVNLESGEFVEGDTVVAVV FT DPGWRRGAAQGHSGTHIVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGSLTGEQRTQ FT IEEVTNEAVQADFEVHTFTEKLDTAKAMGAIALFGEAYPDEVRVVEMGGPFSLELCGGT FT HVHNTAQIGPVTILGESSIGSGVRRVEAYVGLDSFRHLAKERALMAGLASSLQVPSEEV FT HARVATLVERLKAAEKELERARQANVQAAATKAAAGAEWIGNVRVVVQRMSGPIAPDDL FT RFLVGDIRGKLGSDPAVVALIAVTSDGPTATVPYAVAANPAAQDLGIRANDLVEQLAMV FT VDGRGGGKADLAQGSGKDPTGIDAALDTVRAQIAQVG" FT misc_feature 278171..280849 FT /note="Pfam match to entry PF01411 tRNA-synt_2c, tRNA FT synthetases class II (A), score 993.10, E-value 6.5e-295" FT misc_feature 278849..278878 FT /note="PS00339 Aminoacyl-transfer RNA synthetases class-II FT signature 2" FT CDS 280886..281440 FT /transl_table=11 FT /gene="ML0513" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2554c, hypothetical FT protein, SW:YP54_MYCTU (P94999) (170 aa); Fasta score E(): FT 0, 72.0% identity in 161 aa overlap. Similar to many FT bacterial hypothetical proteins e.g. Streptomyces FT coelicolor SC9C5.24C, hypothetical protein, TR:CAB93380 FT (EMBL:AL357523) (167 aa); Fasta score E(): 8.9e-25, 54.8% FT identity in 155 aa overlap." FT /db_xref="GOA:Q9CCS9" FT /db_xref="InterPro:IPR006641" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCS9" FT /protein_id="CAC30021.1" FT /translation="MFSSQHRLLYQPSGPDLSKNLDPERGRRLGIDVGSVRIGVAFSDP FT DGILATPVETVRRYRSAKHLRRLAELVVELQVVEVVVGLPWTLTDRTGSSAKDAIDTAE FT ALARRVAPVPVRLVDERLTTVSAQRLLRAAGVRAKDQRAVIDQAAAVVILQNWLDQCRA FT ATPARADEPTTGSVAGEVIDG" FT RBS 281420..281423 FT /note="possible RBS" FT CDS 281433..282698 FT /transl_table=11 FT /gene="ML0514" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv2553c, hypothetical FT protein, TR:P95000 (EMBL:AL123456) (417 aa); Fasta score FT E(): 0, 72.7% identity in 414 aa overlap. C-terminal half FT is similar to e.g. Streptomyces sphaeroides novB, gene from FT novobiocin biosynthetic gene cluster, TR:AAF67495 FT (EMBL:AF170880) (284 aa); Fasta score E(): 2.5e-22, 40.0% FT identity in 210 aa overlap. Shows full-length similarity to FT other hypothetical proteins e.g. Bacillus subtilis yrrL, FT hypothetical protein, TR:O34758 (EMBL:Z99117) (360 aa); FT Fasta score E(): 2.8e-10, 26.3% identity in 358 aa overlap. FT Contains hydrophobic, possible membrane-spanning region FT near the N-terminus." FT /db_xref="InterPro:IPR003770" FT /db_xref="UniProtKB/TrEMBL:Q9CCS8" FT /protein_id="CAC30022.1" FT /translation="MGDSYLARHRLAPEAAGLGRHQMSSGDRDGRRLAKSGYRCRRFAD FT KIVFGLLVVVVVLATFVGLRLWHTLFGSADGYTDYAGAGKHDIMIQIHAGDSTTVIGET FT LRNQGVVASVRAFVDASHGNAAISSIQPGFYRMRTEIPAAAAAARLADPENRVGKLVIP FT EGRQLDDATDMTTGKVNPGIFSLISRATCVDLDGNRHCVSLNDLRAATRRTSLAKLSVP FT AWATESVIELGNDHRRIEGLIAPGTFNVDPSASADSIMANLISTSAVGYTDSGLVDTAR FT SLGLSPYAILVVASLVQQEASPQDFPKVARVIYNRLYEHRTLEFDSTVNYPLDRREVAT FT SDADRGLWTPWNTYVSPGLPATAICSPGIDALYAAEHPEPGDWLYFVTVDTQGTTLFTR FT DYQQHLTNIELAKHNGVLDSVR" FT CDS 282676..283512 FT /transl_table=11 FT /gene="aroE" FT /gene_synonym="ML0515" FT /product="putative shikimate 5-dehydrogenase" FT /note="Similar to M. tuberculosis aroE, Rv2552c, shikimate FT 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta FT score E(): 0, 81.5% identity in 270 aa overlap. Similar to FT many e.g. Neisseria meningitidis aroE, shikimate FT dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta FT score E(): 2.5e-12, 29.6% identity in 274 aa overlap. FT Contains Pfam match to entry PF01488 Shikimate_DH, FT Shikimate / quinate 5-dehydrogenase." FT /db_xref="GOA:Q9CCS7" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CCS7" FT /protein_id="CAC30023.1" FT /translation="MSLTACANKGPRKAGIIGSPIAHSRSPHLHLAAYRALRLHDWTYE FT RIECDAEELPTVVSGFGPQWVGVSVTMPGKFAALRFADEHTARASLVGSANTLLRTQRG FT WRADNTDIDGVAGALAAIGPLAGRALVCGSGGTAPAAVMGLAELGVTDITVLARNPDKA FT SRLVDLGVQVGVATRLCGLDSGGLADEVKAAEVLVSTVPADVAARYVDVFATVPVLLDA FT IYDPWPTPLVAAVSAAGGRVISGLQMLLHQAFAQVEQFTGMPAPREAMACALAGLH" FT misc_feature 282760..283464 FT /note="Pfam match to entry PF01488 Shikimate_DH, Shikimate FT / quinate 5-dehydrogenase, score 229.00, E-value 6.9e-65" FT RBS 283730..283733 FT /note="possible RBS" FT CDS 283741..284964 FT /transl_table=11 FT /gene="aroF" FT /gene_synonym="ML0516" FT /product="putative chorismate synthase" FT /EC_number="4.6.1.4" FT /note="Similar to M. tuberculosis aroF, Rv2540c, chorismate FT synthase, SW:AROC_MYCTU (P95013) (401 aa); Fasta score E(): FT 0, 88.0% identity in 401 aa overlap. Similar to many e.g. FT Staphylococcus aureus aroC, chorismate synthase, FT SW:AROC_STAAU (Q59803) (388 aa); Fasta score E(): 0, 43.1% FT identity in 383 aa overlap. Contains Pfam match to entry FT PF01264 Chorismate_synt, Chorismate synthase. Contains FT PS00788 Chorismate synthase signature 2. Contains PS00789 FT Chorismate synthase signature 3. Contains PS00787 FT Chorismate synthase signature 1." FT /db_xref="GOA:Q9CCS6" FT /db_xref="InterPro:IPR000453" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCS6" FT /protein_id="CAC30024.1" FT /translation="MLRWITAGESHGRALVAVVEGMVAGVEVTSTAIADQLARRRLGYG FT RGARMAFERDGVTVLSGVRHGVTLGGPIAIEIDNTEWPKWESVMAADPVDAAELEDSAR FT NAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTIARQFLRQALGVEV FT LSHVISIGASARYDGPPPGSEDLTVIDASLVRAFDEQVEKSMIAEIEAAKKDGDTLGGV FT VEAVVLGLPVGLGSFTSGDDRLDSQLAAAVMGIQAIKGVEIGDGFATARRRGSCAHDEM FT YSGPGGVVRLTNRSGGLEGGMTNGQPLRVRAAMKPISTVPRALATVDLATGEEAIAIHQ FT RSDVCAVPAAGVVVETMVALVLARAALRKFGGDSLGETRRNLAAYQRAVADREAPVAQY FT CGESGIGG" FT misc_feature 283744..284850 FT /note="Pfam match to entry PF01264 Chorismate_synt, FT Chorismate synthase, score 695.80, E-value 8.2e-212" FT misc_feature 283762..283809 FT /note="PS00787 Chorismate synthase signature 1" FT misc_feature 284140..284184 FT /note="PS00788 Chorismate synthase signature 2" FT misc_feature 284761..284811 FT /note="PS00789 Chorismate synthase signature 3" FT CDS 284972..285571 FT /transl_table=11 FT /gene="aroK" FT /gene_synonym="ML0517" FT /product="putative shikimate kinase" FT /EC_number="2.7.1.71" FT /note="Similar to M. tuberculosis aroK, Rv2539c, shikimate FT kinase, SW:AROK_MYCTU (P95014) (176 aa); Fasta score E(): FT 0, 79.6% identity in 167 aa overlap. Similar to many e.g. FT Escherichia coli aroK, shikimate kinase I, SW:AROK_ECOLI FT (P24167) (172 aa); Fasta score E(): 3.5e-13, 38.0% identity FT in 166 aa overlap. Contains Pfam match to entry PF01202 FT SKI, Shikimate kinase. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop). Contains PS01128 Shikimate kinase FT signature." FT /db_xref="GOA:Q9CCS5" FT /db_xref="HSSP:1L4U" FT /db_xref="InterPro:IPR000623" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCS5" FT /protein_id="CAC30025.1" FT /translation="MAPKAVLVGLPGAGKSTIGRRLSKALGVSLLDTDAAIEKQTGRSI FT ADIFAIDGEEEFRRIEEGVVRAALVEHDGVVSLGGGAVTSPGVCAALAGHIVIYLEINA FT EEAMRRACGSTVRPLLAGPDRAEKFQDLMARRVPLYRRVATIRVDTNCHNLGAVVRYIM FT ARLQAQLATPVSGGDRKSSEAERSGAPLRKSSEVVK" FT misc_feature 284978..285472 FT /note="Pfam match to entry PF01202 SKI, Shikimate kinase, FT score 226.20, E-value 4.9e-64" FT misc_feature 284996..285019 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 285143..285220 FT /note="PS01128 Shikimate kinase signature" FT RBS 285557..285561 FT /note="possible RBS" FT CDS 285568..286653 FT /transl_table=11 FT /gene="aroB" FT /gene_synonym="ML0518" FT /product="putative 3-dehydroquinate synthase" FT /EC_number="4.6.1.3" FT /note="Similar to M. tuberculosis aroB, Rv2538c, FT 3-dehydroquinate synthase, SW:AROB_MYCTU (P36919) (362 aa); FT Fasta score E(): 0, 87.3% identity in 361 aa overlap. FT Contains Pfam match to entry PF01761 DHQ_synthase, FT 3-dehydroquinate synthase." FT /db_xref="GOA:Q9CCS4" FT /db_xref="HSSP:1NUA" FT /db_xref="InterPro:IPR016037" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCS4" FT /protein_id="CAC30026.1" FT /translation="MTNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRHRVAILHQ FT PVLTQTAEAIRSHLAGKGVDAHRIEIPDAEAGKDLSVMDFIWEVLGRIGIGRKDALVSF FT GGGAATDVAGFAAATWLRGVSIVHVPTTLLGMVDAAVGGKTGINTEAGKNLVGAFHQPL FT AVLADLATLETLPRKEIASGMAEVVKAGFIADPIILDLIEADPQASLDPMGGVLPELIR FT RAVTVKAGVVSADEKESELREILNYGHTLAHAIERRERYEWRHGAAVSVGLVFAAELAR FT VAGRLDDATAQRHHTILTSLGLPVSYDADALPQLLEYMAGDKKTRAGVLRFVILDGLAK FT PGRLVGPDPGLLVTAYAGLSA" FT misc_feature 285628..286638 FT /note="Pfam match to entry PF01761 DHQ_synthase, FT 3-dehydroquinate synthase, score 601.80, E-value 4.1e-177" FT CDS 286653..287090 FT /transl_table=11 FT /gene="aroD" FT /gene_synonym="ML0519" FT /product="3-dehydroquinate dehydratase" FT /EC_number="4.2.1.10" FT /note="Similar to M. tuberculosis aroD, 3-dehydroquinate FT dehydratase, SW:AROQ_MYCTU (P36918) (146 aa); Fasta score FT E(): 0, 85.9% identity in 142 aa overlap. Similar to many FT e.g. Corynebacterium pseudotuberculosis aroQ, FT 3-dehydroquinate dehydratase, SW:AROQ_CORPS (P96750) (146 FT aa); Fasta score E(): 6.7e-33, 61.0% identity in 136 aa FT overlap. Contains Pfam match to entry PF01220 DHquinase_II, FT Dehydroquinase class II. Contains PS01029 Dehydroquinase FT class II signature." FT /db_xref="GOA:Q9CCS3" FT /db_xref="HSSP:1H0S" FT /db_xref="InterPro:IPR018509" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCS3" FT /protein_id="CAC30027.1" FT /translation="MTMVNIINGPNLGRLGRREPDVYGSTTHEQLSALIERAAVEFGIK FT AVVRQSDSESQLLDWIHLAADAGEPVILNAGGLTHTSVALRDACAELSAPFIEVHISNV FT HAREEFRRHSYLSPLATGVITGLGVQGYLLALRYLAEIAGN" FT misc_feature 286656..287087 FT /note="Pfam match to entry PF01220 DHquinase_II, FT Dehydroquinase class II, score 300.70, E-value 1.8e-86" FT misc_feature 286671..286724 FT /note="PS01029 Dehydroquinase class II signature" FT CDS complement(287179..287787) FT /transl_table=11 FT /gene="ML0520" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv2536, possible membrane FT protein, TR:P95017 (EMBL:AL123456) (230 aa); Fasta score FT E(): 0, 63.2% identity in 201 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions. Contains FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site8." FT /db_xref="UniProtKB/TrEMBL:Q9CCS2" FT /protein_id="CAC30028.1" FT /translation="MNNWMLRGLVFAALMIVVRLMQGTMINVWQAQSVLISVVLLAVFI FT IAVVVWAARDGRADAIANPDPDRRRDLAMTWLLTGILVGVLSDAVAWVISLLYNGIYTG FT GLVSELTTFSAFTALIVFLTGIIGVACGRWRVDRRSPPVPEHSRSGQNRADSNVFAAVC FT TDDDTPTGELSAAQTKEQTAAVATAESEAPTEIIYHQRA" FT misc_feature complement(287395..287427) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site8" FT RBS complement(287792..287795) FT /note="possible RBS" FT CDS 287821..288951 FT /transl_table=11 FT /gene="pepQ" FT /gene_synonym="ML0521" FT /product="putative cytoplasmic peptidase" FT /note="Similar to M. tuberculosis pepQ, Rv2535c, putative FT cytoplasmic peptidase, TR:P95018 (EMBL:AL123456) (372 aa); FT Fasta score E(): 0, 83.0% identity in 376 aa overlap. FT Similar to many e.g. Pyrococcus furiosus cobalt-dependent FT proline dipeptidase, TR:P81535 (EMBL:AF060010) (348 aa); FT Fasta score E(): 1.6e-29, 33.7% identity in 359 aa overlap. FT Contains Pfam match to entry PF00557 Peptidase_M24, FT metallopeptidase family M24. Contains PS00491 FT Aminopeptidase P and proline dipeptidase signature. FT Contains PS00211 ABC transporters family signature." FT /db_xref="GOA:Q9CCS1" FT /db_xref="HSSP:1A16" FT /db_xref="InterPro:IPR001714" FT /db_xref="UniProtKB/TrEMBL:Q9CCS1" FT /protein_id="CAC30029.1" FT /translation="MTHSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTGSNGALLV FT FADERGAVLATDGRYRTQAAQQVPELEVAIEQSCGRYLAGRAADDGVCILGFESHVVTV FT DGLDALTGELEGRHTELVRAPGTVEVLREVKDAGELALLRLAAEAADAALTELVARGGV FT RPGLTEREVGRELEGLMLDHGADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFVKIDF FT GALVAGYHSDMTRTFVLGPAADWQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLI FT VDAGYGQQFSHGLGHGVGLEIHEAPGIGTTSAGTLLAGSVVTVEPGVYLSGRGGVRIED FT TLVVAAKGTSETPITSRPTGFIPELLTRFPKELAIL" FT misc_feature 288217..288906 FT /note="Pfam match to entry PF00557 Peptidase_M24, FT metallopeptidase family M24, score 200.70, E-value 2.3e-56" FT misc_feature 288454..288498 FT /note="PS00211 ABC transporters family signature" FT misc_feature 288694..288732 FT /note="PS00491 Aminopeptidase P and proline dipeptidase FT signature" FT RBS 288950..288954 FT /note="possible RBS" FT misc_feature 288967..289521 FT /note="Pfam match to entry PF01132 EFP, Elongation factor P FT (EF-P), score 438.40, E-value 6.2e-128" FT CDS 288967..289530 FT /transl_table=11 FT /gene="efp" FT /gene_synonym="ML0522" FT /product="elongation factor P" FT /note="Similar to M. tuberculosis efp, Rv2534c, elongation FT factor P, SW:EFP_MYCTU (P95019) (187 aa); Fasta score E(): FT 0, 94.1% identity in 186 aa overlap. Similar to many e.g. FT Brevibacterium lactofermentum efp, elongation factor P, FT SW:EFP_BRELA (X99289) (187 aa); Fasta score E(): 0, 68.8% FT identity in 186 aa overlap. Contains Pfam match to entry FT PF01132 EFP, Elongation factor P (EF-P). Contains PS01275 FT Elongation factor P signature." FT /db_xref="GOA:Q9CCS0" FT /db_xref="InterPro:IPR014722" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCS0" FT /protein_id="CAC30030.1" FT /translation="MATTADFKNGLVLVIDGQLWTIIGFQHVKPGKGPAFVRTKLKNVL FT SGKVVDKTYNAGVKVDTATVDRRDTTYLYRDGANFVFMDSQDYEQHPLPESLVGDTARF FT LLEGMSVQVAFHNGVPLYVELPVTVELEVTHTEPGLQGDRSSAGTKPATLETGAQINVP FT LFINTGDKLKVDSRDGSYLGRVNV" FT misc_feature 289414..289473 FT /note="PS01275 Elongation factor P signature" FT CDS 289533..290105 FT /transl_table=11 FT /gene="nusB" FT /gene_synonym="ML0523" FT /product="putative transcription termination protein" FT /note="Similar to M. tuberculosis nusB, putative FT transcription termination protein, SW:NUSB_MYCTU (P95020) FT (156 aa); Fasta score E(): 0, 75.7% identity in 148 aa FT overlap. Similar to many e.g. Escherichia coli nusB, N FT utilization substance protein B, protein involved in FT regulation of transcription termination, SW:NUSB_ECOLI FT (P04381) (139 aa); Fasta score E(): 7.4e-08, 38.1% identity FT in 139 aa overlap. Contains Pfam match to entry PF01029 FT NusB, NusB family." FT /db_xref="GOA:Q9CCR9" FT /db_xref="HSSP:1EYV" FT /db_xref="InterPro:IPR006027" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCR9" FT /protein_id="CAC30031.1" FT /translation="MSNPVKGRHQARKRAVDLLFEAEARDLSPLEIIEVRSALAKSKLD FT VAPLHPYTVVVAQGVSEHTARIDELIISHLQGWKLDRLPAVDRAILRVSIWELLYADDV FT PEPVAVDEAVELAKELSTDDSPGFVNGLLGKVMLVTPQIRAAAQAVQQAVRMAAGTSED FT HVPQREPAAGQLGQDDSNGGQVAAVCR" FT misc_feature 289551..289943 FT /note="Pfam match to entry PF01029 NusB, NusB family, score FT 172.50, E-value 7.2e-48" FT RBS 290630..290636 FT /note="possible RBS" FT CDS 290643..293495 FT /transl_table=11 FT /gene="adi" FT /gene_synonym="ML0524" FT /product="putative amino acid decarboxylase" FT /note="Similar to M. tuberculosis adi, Rv2531c, putative FT ornithine/arginine decarboxylase, TR:P95022 (EMBL:AL123456) FT (947 aa); Fasta score E(): 0, 86.4% identity in 951 aa FT overlap. Similar to decarboxylases of ornithine and lysine FT e.g. Escherichia coli speC, ornithine decarboxylase, FT constitutive, SW:DCOR_ECOLI (P21169) (731 aa); Fasta score FT E(): 3e-16, 26.8% identity in 650 aa overlap. Contains Pfam FT match to entry PF01276 OKR_DC_1, Orn/Lys/Arg FT decarboxylase." FT /db_xref="GOA:Q9CCR8" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/TrEMBL:Q9CCR8" FT /protein_id="CAC30032.1" FT /translation="MNRDSGHPRRLRVSALAAVANPSYTRIDTWNVLDDACRHLAEVDR FT AGLDTAHDVARVKRLLDRIGAYERYWLYPGAANLAAFRGYLATMATVQLTEEVSLAVRL FT LSEYGDRTALFDTSAPLADQELVAQAKQQQFYTVLLADDAPSTAPDCLAESLRELRNPS FT DDVQFELLVVSSVEDAITAVALNGEIQAAIIRHDLPLRSRDRVPLMNTLLGANDSEGAL FT VTIDRPHDWVECGEWIRELRPHIDLYLLTDESIAAGNDDEPDVYDRTFYRLNDVTDLNS FT TVLAGLRNRFATPFFDALRAYAAAPVGQFHALPVARGASIFNSRSLQDMGEFYGRNIFM FT AETSTTSGGLDSLLDPHGNIKKAMDKAAVTWRANHTYFVTNGTSTANKIVVQSLTRPGD FT IVLIDRNCHKSHHYGLVLAGAYPMYLDAYPLPQFAIYGAVSLRTIKKALLDLEAVRQLD FT RVRMLLLTNCTFDGVVCNPQRVMEEVLAIKPDICFLWDEAWYAFATAVPWARQRTAMVS FT AEQLEQKLWSVEYAEEYRNWCASMAEIPRSQWVDQRLLPDPNRARIRVYATHSTHKSLS FT ALRQASMIHVRDQDFNALARDAFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFQLVR FT LVYDMALVFRHRVRKDRLISKWFRILDESDLVPDEYRASAVSSYRQVRQGALAEWNEAW FT RSDQFVLDPTRVTLFVGKTGMNGYDFREKILMERFGIQINKTSINSVLLIFTIGVTWSS FT VHYLLDVLRRVASDFDRIQKVASGADLALHQRHVEEITQDLPHLPDFSEFDVAFRPENA FT SSFGDMRSAFYAGYEESDREYVHIGTAGRQLAEGRTLVSTTFVVPYPPGFPVLVPGQVV FT SKEIIYFLAQLDVKEIHGYNHELGLSVFTEKALARMIARRNAASAAVGSAFAAFEIPSD FT SAAMGGDVNGDRVEAVAEDA" FT misc_feature 291513..293351 FT /note="Pfam match to entry PF01276 OKR_DC_1, Orn/Lys/Arg FT decarboxylase, score 169.50, E-value 5.4e-47" FT CDS 293492..293668 FT /transl_table=11 FT /gene="ML0525" FT /product="conserved hypothetical protein" FT /note="Unknown function. Similar to M. tuberculosis Rv2493, FT hypothetical protein, TR:O53218 (EMBL:AL123456) (73 aa); FT Fasta score E(): 0.059, 47.7% identity in 44 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCR7" FT /protein_id="CAC30033.1" FT /translation="MIWSPVSKRCSGRVRNIAQPGGHSVGVMISGLARSPLRPGGVVEV FT DGLPVLDVPQPAP" FT CDS complement(294094..294979) FT /pseudo FT /transl_table=11 FT /gene="ML0526" FT /product="possible oxidoreductase (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT Rv0575c (Best blastx score 73)" FT CDS complement(295678..295932) FT /transl_table=11 FT /gene="ML0527" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CCR6" FT /protein_id="CAC30035.1" FT /translation="MVYLENHGVKGHHRQPQRALHQASSSLINAYGYGIKLLCLCPGSI FT PATRTTRQSVVDLTSVSTGTATRTAMTNLAGNIEAAGKT" FT CDS complement(297810..298795) FT /pseudo FT /transl_table=11 FT /gene="ML0528" FT /product="probable penicillin binding protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1367c (Best blastx score 289)" FT CDS complement(298925..299496) FT /pseudo FT /transl_table=11 FT /gene="ML0529" FT /product="some similarity to methyltransferases FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1377c (Best blastx score 217)" FT CDS complement(299652..301020) FT /pseudo FT /transl_table=11 FT /gene="ML0530" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1378c (Best blastx score 627)" FT CDS 301041..301572 FT /pseudo FT /transl_table=11 FT /gene="pyrR" FT /gene_synonym="ML0531" FT /product="regulatory protein pyrimidine biosynthesis FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT pyrR (Best blastx score 355)" FT CDS 301581..302546 FT /transl_table=11 FT /gene="pyrB" FT /gene_synonym="ML0532" FT /product="putative aspartate carbamoyltransferase" FT /EC_number="2.1.3.2" FT /note="Similar to M. tuberculosis pyrB, Rv1380, aspartate FT carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); FT Fasta score E(): 0, 89.9% identity in 318 aa overlap. FT Similar to many e.g. Pseudomonas putida, aspartate FT carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); FT Fasta score E(): 0, 47.3% identity in 317 aa overlap. FT Contains 2 Pfam matches to entry PF00185 OTCace, FT Aspartate/ornithine carbamoyltransferase. Contains PS00097 FT Aspartate and ornithine carbamoyltransferases signature." FT /note="Shows weak similarity to ML1410" FT /db_xref="GOA:Q9CCR5" FT /db_xref="HSSP:1ML4" FT /db_xref="InterPro:IPR002082" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCR5" FT /protein_id="CAC30040.1" FT /translation="MMRRHLLNAGDLSRDDAIAIFDDADRFAHALVGREIKKLPTLRGR FT TVITMFYENSTRTRVSFEVAGKWMSANVINVSPAGSSVGKGESLRDTALTLRAAGADAL FT IIRHPASGAAHLLADWTAAETGEDGPAVINAGDGTHEHPTQALLDALTIRQRLGSIEGR FT RILIVGDILHSRVARSNVVLLDTLGAEVVLVAPRTLLPIGVDGWPATVSCDFDAELPAA FT DAVLMLRVQAERMNGGFFPSVREYSCLYGLTERRQALLPGHAVVLHPGPMLRGMEIASS FT VADSSQSAVLQQVSNGVHVRMAVLFHVLVGTQSAEEEGAA" FT misc_feature 301590..302183 FT /note="Pfam match to entry PF00185 OTCace, FT Aspartate/ornithine carbamoyltransferase, score 173.40, FT E-value 3.7e-48" FT misc_feature 301731..301754 FT /note="PS00097 Aspartate and ornithine FT carbamoyltransferases signature" FT misc_feature 302328..302507 FT /note="Pfam match to entry PF00185 OTCace, FT Aspartate/ornithine carbamoyltransferase, score 31.40, FT E-value 8.4e-08" FT RBS 302530..302535 FT /note="possible RBS" FT CDS 302543..303835 FT /transl_table=11 FT /gene="pyrC" FT /gene_synonym="ML0533" FT /product="putative dihydroorotase" FT /EC_number="3.5.2.3" FT /note="Similar to M. tuberculosis pyrC, Rv1381, FT dihydroorotase, TR:P71809 (EMBL:AL123456) (430 aa); Fasta FT score E(): 0, 88.8% identity in 427 aa overlap. Similar to FT many e.g. Bacillus caldolyticus pyrC, dihydroorotase, FT SW:PYRC_BACCL (P46538) (427 aa); Fasta score E(): 0, 40.0% FT identity in 407 aa overlap. Contains Pfam match to entry FT PF00744 Dihydrooratase, Dihydroorotase-like." FT /db_xref="GOA:Q9CCR4" FT /db_xref="InterPro:IPR002195" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCR4" FT /protein_id="CAC30041.1" FT /translation="MSVLLRGVRLYGEGEQVDVLVEGEQIANIGAGIDIPDTADVIDAI FT DQVLLPGLVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMPNTTPVADSPVVTDH FT VWRRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMAAGAAQVRIFSDDGNCVHNPLVMRR FT ALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLSGWPRAAEESIVARDALLARD FT AGARVHICHASTAGTVEILKWAKEQGISITAEVTPHHLLLDDSRLASYDGVNRVNPPLR FT ETADAVALRQALADGIIDCVTTDHAPHADHEKCVEFSAARPGMLGLQTALSVVVHTMVV FT PGLLSWRDVAQVMSENPARIAGLPDHGRPLEVGEPANLTVVDPDVTWTVTGDGLASRSA FT NTPYEAMTLPATVTATLLRGKVTARGQKSPV" FT misc_feature 302660..303808 FT /note="Pfam match to entry PF00744 Dihydrooratase, FT Dihydroorotase-like, score 266.90, E-value 2.7e-76" FT CDS 303832..304321 FT /pseudo FT /transl_table=11 FT /gene="ML0534" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1382 (Best blastx score 331)" FT RBS 304407..304413 FT /note="possible RBS" FT CDS 304422..305549 FT /transl_table=11 FT /gene="carA" FT /gene_synonym="ML0535" FT /product="putative carbamoyl-phosphate synthase subunit" FT /EC_number="6.3.5.5" FT /note="Similar to M. tuberculosis carA, Rv1383, FT carbamoyl-phosphate synthase subunit, TR:P71811 FT (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% FT identity in 377 aa overlap. Similar to many e.g. FT Escherichia coli carA, carbamoyl-phosphate synthase FT subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): FT 0, 43.2% identity in 389 aa overlap. Contains Pfam match to FT entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase FT small chain, CPSase domain. Contains Pfam match to entry FT PF00117 GATase, Glutamine amidotransferase class-I. FT Contains PS00442 Glutamine amidotransferases class-I active FT site." FT /db_xref="GOA:Q9CCR3" FT /db_xref="HSSP:1CS0" FT /db_xref="InterPro:IPR000991" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCR3" FT /protein_id="CAC30043.1" FT /translation="MSKALLVLEDGRVFTGMPFGAIGQTLGEAVFSTGMSGYQETLTDP FT SYHRQIVVATAPQIGNTGWNDQDGESRDDRIWVAGYAVRDPSPCASNWRATGTLEDELV FT RQRIVGIAGIDTRAVVRHLRRYGSMKAGVFSGKAMIEPLNIEALVQHVRTQQSMLGADL FT VGEASTLDAYVVEPKGKERFTVAALDLGIKTNTPRNFARRGIRSYVLPASATFNQIADI FT KPHGLFLSNGPGDPATADHVVALTREVLNAGIPLFGICFGNQILGRALGLSTYKMVFGH FT RGINIPVIDHATGRVAVTAQNHGFALEGEAGQSFDTPFGSAVVSHTCANDGVVEGVKLA FT DGRAFSVQYHPEAAAGPHDAEYLFDSFVELMAAQR" FT misc_feature 304431..304928 FT /note="Pfam match to entry PF00988 CPSase_sm_chain, FT Carbamoyl-phosphate synthase small chain, CPSase domain, FT score 282.20, E-value 6.7e-81" FT misc_feature 304977..305531 FT /note="Pfam match to entry PF00117 GATase, Glutamine FT amidotransferase class-I, score 185.60, E-value 7.8e-52" FT misc_feature 305184..305219 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT RBS 305596..305603 FT /note="possible RBS" FT CDS 305608..308997 FT /transl_table=11 FT /gene="carB" FT /gene_synonym="ML0536" FT /product="putative carbamoyl-phosphate synthase subunit" FT /EC_number="6.3.5.5" FT /note="Similar to M. tuberculosis carB, Rv1384, FT carbamoyl-phosphate synthase subunit. Similar to many e.g. FT Escherichia coli carB, carbamoyl-phosphate synthase FT subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): FT 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam FT matches to entry PF00289 CPSase_L_chain, FT Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 FT Carbamoyl-phosphate synthase subdomain signature 2. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site. Contains PS00866 Carbamoyl-phosphate FT synthase subdomain signature 1." FT /db_xref="GOA:Q9CCR2" FT /db_xref="HSSP:1M6V" FT /db_xref="InterPro:IPR011761" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCR2" FT /protein_id="CAC30044.1" FT /translation="MRPERGTLVPRRTDLNHVLVIGSGPIVIGQACEFDYAGTQACRVL FT RAEGLQVSLVNSNPATIMTDPEFADHTYVEPITPAFVERVIVQQAERGNRIDALLATLG FT GQTALNTAVALYENGVLERYGVELIGADFEAIQRGEDRQRFKDLVAKVGGESARSKVCF FT TMDEVRETVEDLGLPVVVRPSFTMGGLGSGMAHSDEEVGRMAGAGLVASPSANVLIEES FT VYGWKEFELELMRDGHDSVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDWEYQRMRDLG FT IAILREVGVDTGGCNIQFAINPHDGRLIVIEMNPRVSRSSALASKATGFPIAKIAVKLA FT VGYTLDEILNDITKETPACFEPALDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSL FT GRNFVEALGKVMRSLETGRFGFWTAPDPQGDVDQVLLRLKTPTEGRLYDVELALRLGAS FT TEKVAQVSGIDPWFVAQIGELVKLRDELVAAPVLDAELLRRAKHNGLSDRQITALRPEL FT LGEDGVRSLRKRLGIHPVYKTVDTCAAEFEAKTPYHYSSYELDPAAETEVVPQTEKPKV FT LILGSGPNRIGQGIEFDYSCVHAAITLSHNGFETVMVNCNPETVSTDYDTADRLYFEPL FT TFEDVLEVFYAEEQSAAGGAGVAGVIVQLGGQTPLGLAQRLADAGVPIVGTSPEAIDLA FT EDRGAFGDVLTAAGLPAPKYGTATTFAQARRIAAEIGYPVLVRPSYVLGGRGMEIVYDE FT ETLKDYITRATALSHEHPVLVDRFLEDAVEIDVDALCDGTEVYIGGVMEHIEEAGIHSG FT DSACALPPVTLGRSDLEKVRQATEAIARGIGVVGLLNVQYALKEDVLYVLEANPRASRT FT VPFVSKATAIPLAKACARIMLGSSISQLRFEGMLAASGDGGNVASHAPIAVKEAVLPFN FT RLRRADGAAIDSLLGPEMKSTGEVMGIDHDFGRAFAKSQTAAYGSLPTQGTVFVSVANR FT DKRLLVFPVKRLADLGFHVIATEGTAEMLRRKGIPCDEVRKHFEPPKAGRPALSAVDAI FT RAGDVDMVINTPYGNSGPRIDGYEIRSAAVSVNIPCVTTVQGASAAVQGIEAGIRGDIG FT VRSLQELHSAIGAGIAADNEVQ" FT misc_feature 305656..306864 FT /note="Pfam match to entry PF00289 CPSase_L_chain, FT Carbamoyl-phosphate synthase (CPSase), score 551.50, FT E-value 5.7e-162" FT misc_feature 305671..305703 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT misc_feature 306535..306558 FT /note="PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2" FT misc_feature 307330..308307 FT /note="Pfam match to entry PF00289 CPSase_L_chain, FT Carbamoyl-phosphate synthase (CPSase), score 188.30, FT E-value 5.9e-53" FT misc_feature 307801..307845 FT /note="PS00866 Carbamoyl-phosphate synthase subdomain FT signature 1" FT misc_feature 308188..308211 FT /note="PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2" FT RBS 308986..308990 FT /note="possible RBS" FT CDS 308994..309842 FT /transl_table=11 FT /gene="pyrF" FT /gene_synonym="ML0537" FT /product="orotidine 5'-phosphate decarboxylase" FT /EC_number="4.1.1.23" FT /note="Similar to M. tuberculosis pyrF, Rv1385, orotidine FT 5'-phosphate decarboxylase, SW:DCOP_MYCTU (P77898) (274 FT aa); Fasta score E(): 0, 77.3% identity in 282 aa overlap. FT Similar to many e.g. Mycobacterium smegmatis pyrF, FT orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCSM FT (O08323) (276 aa); Fasta score E(): 0, 72.5% identity in FT 280 aa overlap. Contains Pfam match to entry PF00215 FT OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains FT PS00156 Orotidine 5'-phosphate decarboxylase active site." FT /db_xref="GOA:Q9CCR1" FT /db_xref="InterPro:IPR001754" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCR1" FT /protein_id="CAC30045.1" FT /translation="MTGFGARLVEATSRRGQLCLGIDPHPELLRAWDLPTTADGLAAFC FT DICVEAFSGFAIVKPQVAFFEAYGAAGFAVLEYTIAALRSVGVLVLADAKRGDIGSTMA FT AYAAAWAGNSPLAADAVTASPYLGFGSLRPLLEVAAAHDRGVFVLASTSNLEGATVQRA FT TFDGRIVAQLIVDQAAFVNREMNRSFHRSEPGCLGYVGVVVGATVFGAPDVSALGGPVL FT VPGVGAQGGHPEALGGLGGAAPGQLLPAVSRAVLRAGPGVSELRAAGEQMRDAVAYLAA FT V" FT misc_feature 309003..309839 FT /note="Pfam match to entry PF00215 OMPdecase, Orotidine FT 5'-phosphate decarboxylases, score 188.80, E-value 9.5e-54" FT misc_feature 309261..309302 FT /note="PS00156 Orotidine 5'-phosphate decarboxylase active FT site" FT RBS 310117..310120 FT /note="possible RBS" FT CDS 310129..310437 FT /transl_table=11 FT /gene="PE" FT /gene_synonym="ML0538" FT /product="PE-family protein" FT /note="Similar to M. tuberculosis PE, Rv1386, PE-family FT protein, SW:YD86_MYCTU (P71656) (102 aa); Fasta score E(): FT 2.8e-25, 72.5% identity in 102 aa overlap." FT /note="Similar to ML452, ML1183 and ML2129" FT /db_xref="InterPro:IPR000084" FT /db_xref="UniProtKB/TrEMBL:Q9CCR0" FT /protein_id="CAC30046.1" FT /translation="MTLGVIPEGLEGASAVIEALTAHLATVHAEAAPFIMEVIPPGSGS FT VSVQNQVGFNVHGCQYVAMTAHGAEELGRWGVGVAESGVSYALRDAFAVASYLGGGL" FT CDS 310434..312050 FT /transl_table=11 FT /gene="PPE" FT /gene_synonym="ML0539" FT /product="PPE-family protein" FT /note="Similar to M. tuberculosis PPE, Rv1387, PPE-family FT protein, TR:P71657 (EMBL:AL123456) (539 aa); Fasta score FT E(): 0, 69.5% identity in 544 aa overlap. Contains Pfam FT match to entry PF00823 PPE, PPE family." FT /note="Similar to ML0411, ML1182, ML1828 and ML1991" FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:Q9CCQ9" FT /protein_id="CAC30047.1" FT /translation="MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAEYRWVAS FT EVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVATQQEVVAAAYAAAVE FT AMPTQFELAANRVVRGVLMATNFFGVNTIPIALNEEEYVQMWVRAATTMATYSAISQSA FT LAATPQATPPPLILKSNVLVDDVEKDSRHDGHSHGGHASAMDRVFADILRNVSGGRLVW FT DPLNGTLNGLDYDDYVYPGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVL FT DLPTHIVQLGTWLAEYPQLLLVALGGTIANLGAVTGLAGLSSGLSAGPSAAIPTVVPES FT APIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAPPGTGFGGFSPYLVD FT GRGPGVGFGSGRQSAYANKVSESVSDSAVAEAAAQASAREQARAWRRRSAAKERGYREE FT VITMNTGFDAAIPSPVDQTGSRVSDCGAGSFGFAGTVSKEAVVEVAGLTTLAGDDFGGG FT PTMPMVPGTWAPARESSDEGR" FT misc_feature 310452..310928 FT /note="Pfam match to entry PF00823 PPE, PPE family, score FT 202.80, E-value 5.3e-57" FT RBS 312886..312890 FT /note="possible RBS" FT CDS 312895..313212 FT /transl_table=11 FT /gene="mihF" FT /gene_synonym="ML0540" FT /product="putative integration host factor" FT /note="Similar to M. tuberculosis mihF, Rv1388, possible FT integration host factor, TR:P71658 (EMBL:AL123456) (190 FT aa); Fasta score E(): 0, 98.1% identity in 105 aa overlap. FT Similar to Mycobacterium smegmatis mihF, integration host FT factor, TR:P96802 (EMBL:U75344) (105 aa); Fasta score E(): FT 7.5e-32, 94.1% identity in 102 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CCQ8" FT /protein_id="CAC30048.1" FT /translation="MALPQLTDEQRAAALEKAAAARRARAELKDRLKRGGTNLTQVLKD FT AESDEVLGKMKVSALLEALPKVGKVKAQEIMTELDIAPTRRLRGLGERQRKALLEKFGS FT A" FT RBS 313248..313252 FT /note="possible RBS" FT CDS 313266..313898 FT /transl_table=11 FT /gene="gmk" FT /gene_synonym="ML0541" FT /product="putative guanylate kinase" FT /EC_number="2.7.4.8" FT /note="Similar to M. tuberculosis gmk, Rv1389, putative FT guanylate kinase, SW:KGUA_MYCTU (P71659) (208 aa); Fasta FT score E(): 0, 79.1% identity in 201 aa overlap. Similar to FT many e.g. Saccharomyces cerevisiae guk1, guanylate kinase, FT SW:KGUA_YEAST (P15454) (186 aa); Fasta score E(): 7.1e-22, FT 42.8% identity in 180 aa overlap. Contains Pfam match to FT entry PF00625 Guanylate_kin, Guanylate kinase. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop). Contains FT PS00856 Guanylate kinase signature." FT /db_xref="GOA:Q9CCQ7" FT /db_xref="HSSP:1LVG" FT /db_xref="InterPro:IPR008145" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCQ7" FT /protein_id="CAC30049.1" FT /translation="MPVSARGAPDAEHWAWSEQTDKGRVVVLSGPSAVGKSTVVRCLRE FT RVSNLHFSVSATTREPRPDEMDGVDYHFVSPARFQQLIDQGALLEWAEIHGGMHRSGTL FT AEPVRVAAAAGFPVLIEVDLAGARAVKKAMPEAIAVFLAPPSWEDLEARLVGRGTETPE FT AIRRRLETARIELAAQDDFDEVVVNRRLESACAELVSLLVGAVSGSA" FT misc_feature 313353..313376 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 313434..313487 FT /note="PS00856 Guanylate kinase signature" FT misc_feature 313437..313757 FT /note="Pfam match to entry PF00625 Guanylate_kin, Guanylate FT kinase, score 104.00, E-value 3e-27" FT RBS 313965..313971 FT /note="possible RBS" FT CDS 313980..314312 FT /transl_table=11 FT /gene="ML0542" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1390, conserved FT hypothetical protein, SW:YD90_MYCTU (P71660) (110 aa); FT Fasta score E(): 0, 90.0% identity in 110 aa overlap. Also FT similar to Streptomyces coelicolor SC9C5.02C, hypothetical FT protein, TR:CAB93358 (EMBL:AL357523) (90 aa); Fasta score FT E(): 2e-18, 71.3% identity in 80 aa overlap." FT /db_xref="GOA:Q9CCQ6" FT /db_xref="InterPro:IPR006110" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCQ6" FT /protein_id="CAC30050.1" FT /translation="MSIPQSNTSLSAVIAVDQFDPSSGGQGVYDTPLGITNPPIDELLD FT RVSSKYALVIYAAKRARQINDHYNQLGEGILEYVGPLVEPGLQEKPLSIAMREIHADLL FT EHTEGE" FT RBS 314326..314332 FT /note="possible RBS" FT CDS 314333..315592 FT /transl_table=11 FT /gene="dfp" FT /gene_synonym="ML0543" FT /product="putative flavoprotein" FT /note="Similar to M. tuberculosis dfp, Rv1391, putative FT flavoprotein, SW:DFP_MYCTU (P71661) (418 aa); Fasta score FT E(): 0, 87.0% identity in 409 aa overlap. Similar to many FT e.g. Escherichia coli dfp, DNA/pantothenate metabolism FT flavoprotein, SW:DFP_ECOLI (P24285) (430 aa); Fasta score FT E(): 0, 39.7% identity in 408 aa overlap." FT /db_xref="GOA:Q9CCQ5" FT /db_xref="HSSP:1E20" FT /db_xref="InterPro:IPR005252" FT /db_xref="UniProtKB/TrEMBL:Q9CCQ5" FT /protein_id="CAC30051.1" FT /translation="MDCKRVVVGVSGGIAAYKACTVVRQLIDAGHEVRVIPTESALRFV FT GTATFEALSGQPVYTDVFDDIPAVSHVYLGKQADLVVVAPATADLLARAVHGRADDLLT FT ATLLTARCPIMFAPAMHTEMWLHPATVDNVATLRRRGAIVLEPASGRLTGTDSGAGRLP FT EAEEITTLAQLLLERHDALPYDLTGRKLLVTSGGTRESIDPVRFIGNRSSGKQGYAVAR FT VAVQRGAEVTLIAGHTAGLTNPAGVDVVHVGSAQQLGDAVSKHAPDFDVLVMAAAVADF FT RPAQVATAKIKKGPDDQDEPLIELVYNEDVLAAAVRARTHGQLPNMRAIVGFAAETGDA FT SGDVLFHARAKLRRKGCDLLVVNAVGDGRAFEVDNNDGWLLASDGTELALQHGSKMLMA FT SRIVDGIVTFLHGLPDLRGG" FT RBS 315704..315709 FT /note="possible RBS" FT CDS 315721..316932 FT /transl_table=11 FT /gene="metK" FT /gene_synonym="ML0544" FT /product="putative S-adenosylmethionine synthase" FT /EC_number="2.5.1.6" FT /note="Similar to M. tuberculosis metK, Rv1392, putative FT S-adenosylmethionine synthase, SW:METK_MYCTU (P77899) (403 FT aa); Fasta score E(): 0, 91.3% identity in 403 aa overlap. FT Similar to Streptomyces spectabilis metK, FT S-adenosylmethionine synthase, SW:METK_STRST (Q9X4Q2) (411 FT aa); Fasta score E(): 0, 73.6% identity in 398 aa overlap. FT Contains Pfam match to entry PF00438 S-AdoMet_synt, FT S-adenosylmethionine synthetase. Contains PS00377 FT S-adenosylmethionine synthetase signature 2. Contains FT PS00376 S-adenosylmethionine synthetase signature 1." FT /db_xref="GOA:Q9CCQ4" FT /db_xref="HSSP:1MXB" FT /db_xref="InterPro:IPR002133" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCQ4" FT /protein_id="CAC30052.1" FT /translation="MSEKGRLFTSESVTEGHPDKICDAISDSILDALLAEDPCSRVAVE FT TLVTTGQVHVVGEVTTLAKTAFADISNTVRERILDIGYDSSDKGFDGASCGVNIGIGAQ FT SSDIAQGVNTAHEVRVEGAADPLDAQGAGDQGLMFGYAINDTPELMPLPIALAHRLARR FT LTEVRKNGVLPYLRSDGKTQVTIAYEDNVPVRLDTVVISTQHAAGVDLDATLAPDIREK FT VLNTVIDDLSHDTLDVSSVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGG FT AFSGKDPSKVDRSAAYAMRWVAKNIVAAGLAERIEVQVAYAIGKAAPVGLFVETFGTEA FT VDPAKIEKAIGEVFDLRPGAIIRDLHLLRPIYAQTAAYGHFGRTDVELPWEQLNKVDDL FT KRAI" FT misc_feature 315736..316893 FT /note="Pfam match to entry PF00438 S-AdoMet_synt, FT S-adenosylmethionine synthetase, score 693.20, E-value FT 3.2e-287" FT misc_feature 316111..316143 FT /note="PS00376 S-adenosylmethionine synthetase signature 1" FT misc_feature 316555..316581 FT /note="PS00377 S-adenosylmethionine synthetase signature 2" FT CDS complement(317595..318509) FT /pseudo FT /transl_table=11 FT /gene="lipH" FT /gene_synonym="ML0545" FT /product="probable lipase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lipH (Best blastx score 213)" FT CDS complement(318674..319497) FT /pseudo FT /transl_table=11 FT /gene="lipI" FT /gene_synonym="ML0546" FT /product="probable lipase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lipI (Best blastx score 262)" FT CDS 319496..319987 FT /pseudo FT /transl_table=11 FT /gene="ML0547" FT /product="possible membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1401 (Best blastx score 114)" FT CDS 320260..322215 FT /transl_table=11 FT /gene="priA" FT /gene_synonym="ML0548" FT /product="putative primosomal protein N'" FT /note="Similar to M. tuberculosis priA, Rv1402, putative FT primosomal protein N', SW:PRIA_MYCTU (P71670) (655 aa); FT Fasta score E(): 0, 80.7% identity in 658 aa overlap. FT Similar to many e.g. Escherichia coli priA, primosomal FT protein N', SW:PRIA_ECOLI (P17888) (732 aa); Fasta score FT E(): 1.2e-16, 28.1% identity in 445 aa overlap." FT /db_xref="GOA:Q9CCQ3" FT /db_xref="InterPro:IPR005259" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCQ3" FT /protein_id="CAC30056.1" FT /translation="MLSVPHLDREFDYLVSAEQSDDAQPGVRVRVRFHGRLVDGFVLER FT RNDTEHFGKLGWLDRVVSAQPVLTAEVRRLVDAVVARYAGTRPDVLRLAVPTRHARVER FT ETLAIPVSPLPLIPGPVDPSGWEVYGRGGQFLTALAESRAARAVWQALPGEQWADRFAE FT AAAQAIRAGRAALAIVPDQRDLDVLWRAVTTRVDERSVVALSAGLGQAVRYQRWLKVLR FT GSARLVIGTRSAVFAPVNDLGLVMVWSDADDMLAEPRAPYPHAREVAMLRAYQARCAAL FT IGGYTRTAEAHALVRSGWAHDVVAARSVVRARAPRVVALDDSGYAEESDPAARTARLPS FT IALRAARSALAAGAPVLVQVPRRGYVPSLACGRCRTLARCRHCTGPLSLLDRATPGTVC FT CWCGRADLTLRCARCGSEVVRAVVVGARRTAEELGRAFAGMPVITSVGDTIVPEVGARP FT ALVVATPGAEPRAPGGYGAALLLDTWALLGRQDLRAAEEALWRWMTAAALVRARGDGGV FT VMVVAEASIPTVQSLMRWDPASHAEAELAARTEVGLPPSVHIAAVDGTTGAVNELLQEA FT RLPDEADLLGPVDLPQGVRRPAGTPLGAPISRLLVRVPREQGWQLAASLRRGIGVLSVR FT QTHQLVRVQIDPLHIG" FT CDS complement(322224..323066) FT /pseudo FT /transl_table=11 FT /gene="ML0549" FT /product="similar to phosphatidylethanolamine FT N-methyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1403c (Best blastx score 822)" FT CDS 323331..323816 FT /transl_table=11 FT /gene="ML0550" FT /product="putative marR-family transcriptional regulator" FT /note="Similar to M. tuberculosis Rv1404, putative FT marR-family transcriptional regulator, TR:P71672 FT (EMBL:AL123456) (160 aa); Fasta score E(): 0, 79.1% FT identity in 158 aa overlap. Shows weak similarity to marR FT family e.g. Salmonella typhimurium marR, multiple FT antibiotic resistance protein, SW:MARR_SALTY (Q56069) (144 FT aa); Fasta score E(): 0.0027, 29.2% identity in 106 aa FT overlap. Contains Pfam match to entry PF01047 MarR, MarR FT family." FT /db_xref="GOA:Q9CCQ2" FT /db_xref="InterPro:IPR000835" FT /db_xref="UniProtKB/TrEMBL:Q9CCQ2" FT /protein_id="CAC30058.1" FT /translation="MVTDDATVADESLDDITDALLTASRLLVAVSAHSIGQVDETITFP FT QFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRELLVAL FT TKRGREVVRRVTAQRRVEIARIVEKMPPSERLGLVRALTAFSTAGGEPDVRLDIISI" FT misc_feature 323454..323765 FT /note="Pfam match to entry PF01047 MarR, MarR family, score FT 99.80, E-value 5.2e-26" FT CDS complement(323998..324822) FT /transl_table=11 FT /gene="ML0551" FT /product="putative methyltransferase" FT /note="Similar to M. tuberculosis Rv1405c, hypothetical FT protein, SW:YE05_MYCTU (P71673) (274 aa); Fasta score E(): FT 0, 78.0% identity in 273 aa overlap. Shows weak similarity FT to methyltransferses e.g. Rhodobacter sphaeroides pmtA, FT phosphatidylethanolamine N-methyltransferase, SW:PMTA_RHOSH FT (Q05197) (203 aa); Fasta score E(): 7.9e-08, 31.3% identity FT in 144 aa overlap and Escherichia coli ubiE, FT ubiquinone/menaquinone biosynthesis methyltransferase, FT SW:UBIE_ECOLI (P27851) (251 aa); Fasta score E(): 9.1e-06, FT 28.0% identity in 118 aa overlap." FT /db_xref="GOA:Q9CCQ1" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q9CCQ1" FT /protein_id="CAC30059.1" FT /translation="MNLYTPIHEDQSLAAIHRAMWALGDYALMAEEVMAPLGPILVTAT FT GIRPGMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRSQARATELGLTLEYREAD FT AQALPFGDGEFDVVMSAIGVMFAPDHRRAASELVRVCRPNGTIGVISWTQEGFFGRMLA FT TIRPYRPSLSAALPPAALWGREAYIRGLLDDTVTNVKTERRQLEVKRFNSAEGVHNYFK FT NHYGPTIEAYTNIGDNSVLAAELDAQLTELAQKYLTNSTMGWEYLLLTAQKH" FT RBS complement(324828..324832) FT /note="possible RBS" FT RBS 324985..324988 FT /note="possible RBS" FT CDS 325003..325959 FT /transl_table=11 FT /gene="fmt" FT /gene_synonym="ML0552" FT /product="putative methionyl-tRNA formyltransferase" FT /EC_number="2.1.2.9" FT /note="Similar to M. tuberculosis fmt, Rv1406, putative FT methionyl-tRNA formyltransferase, SW:FMT_MYCTU (P71674) FT (312 aa); Fasta score E(): 0, 81.0% identity in 316 aa FT overlap. Similar to many e.g. Thermus aquaticus fmt, FT methionyl-tRNA formyltransferase, SW:FMT_THETH (P43523) FT (305 aa); Fasta score E(): 8.1e-31, 41.3% identity in 315 FT aa overlap. Contains Pfam match to entry PF00551 FT formyl_transf, Formyl transferase." FT /db_xref="GOA:Q9CCQ0" FT /db_xref="HSSP:1FMT" FT /db_xref="InterPro:IPR015518" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCQ0" FT /protein_id="CAC30060.1" FT /translation="MLVRLVFAGTPESALPALCRLIDSPRHDVIAVLTRPDAASGRRGK FT PEPSPVAREALDRGIPLLRPARPNSPVFVSELSEWAPECCVVVAYGALLGSPLLAVPPR FT GWVNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPVYGVVTETIQPTDT FT AGDLLERLAVSGATLLSSTLDGIADAILTPRQQPVDGVSFAPKITVEQARVCWDLPAPV FT VERRIRAVTPNPGAWTLVGKLRVKLGPVRFDSGAVEVPRLLKPLLPGGIHVDHKSVWIG FT TGSDPVRLSKVQPQGKKFMNAVDWAHGARLDPAARAS" FT misc_feature 325009..325551 FT /note="Pfam match to entry PF00551 formyl_transf, Formyl FT transferase, score 105.10, E-value 3.9e-29" FT CDS 326028..327362 FT /pseudo FT /transl_table=11 FT /gene="fmu" FT /gene_synonym="ML0553" FT /product="similar to Fmu protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fmu (Best blastx score 1324)" FT CDS 327416..328090 FT /transl_table=11 FT /gene="rpe" FT /gene_synonym="ML0554" FT /product="putatibe ribulose-phosphate 3-epimerase" FT /EC_number="5.1.3.1" FT /note="Similar to M. tuberculosis rpe, Rv1408, FT ribulose-phosphate 3-epimerase, SW:RPE_MYCTU (P71676) (232 FT aa); Fasta score E(): 0, 91.0% identity in 221 aa overlap. FT Similar to many e.g. Oryza sativa D-ribulose-5-phosphate FT 3-epimerase, TR:Q9SE42 (EMBL:AF189365) (228 aa); Fasta FT score E(): 0, 47.0% identity in 215 aa overlap. Contains FT Pfam match to entry PF00834 Ribul_P_3_epim, FT Ribulose-phosphate 3 epimerase family. Contains PS01085 FT Ribulose-phosphate 3-epimerase family signature 1. Contains FT PS01086 Ribulose-phosphate 3-epimerase family signature 2." FT /db_xref="GOA:Q9CCP9" FT /db_xref="HSSP:1H1Y" FT /db_xref="InterPro:IPR000056" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCP9" FT /protein_id="CAC30062.1" FT /translation="MGPLIAPSILAADFARLTDEAAVVASADWLHVDVMDGHFVPNLTI FT GLPVVQSLLAASDIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVAHDIRT FT AGAKAGIGVKPGTPLNPYLDILPHFDTLLIMSVEPGFGGQAFIPEVLSKVRTVRKMVDA FT GELTILVEIDGGINADTIEQAAEAGVDCFVAGSAVYGAADPSAAVAALRRRAGAVSPHL FT RR" FT misc_feature 327425..328021 FT /note="Pfam match to entry PF00834 Ribul_P_3_epim, FT Ribulose-phosphate 3 epimerase family, score 410.10, FT E-value 2e-119" FT misc_feature 327503..327547 FT /note="PS01085 Ribulose-phosphate 3-epimerase family FT signature 1" FT misc_feature 327809..327877 FT /note="PS01086 Ribulose-phosphate 3-epimerase family FT signature 2" FT CDS 328087..329106 FT /transl_table=11 FT /gene="ribG" FT /gene_synonym="ML0555" FT /product="putative bifunctional riboflavin-specific FT deaminase/reductase" FT /EC_number="3.5.4.26" FT /EC_number="1.1.1.193" FT /note="Similar to M. tuberculosis ribG, Rv1409, putative FT riboflavin biosynthesis protein, SW:RIBD_MYCTU (P71677) FT (339 aa); Fasta score E(): 0, 78.2% identity in 339 aa FT overlap. Similar to many e.g. Bacillus subtilis ribD, FT diaminohydroxyphosphoribosylaminopyrimidine deaminase / FT 5-amino-6-(5-phosphoribosylamino)-uracil reductase, FT SW:RIBD_BACSU (P17618) (361 aa); Fasta score E(): 7.9e-33, FT 39.2% identity in 357 aa overlap. Contains Pfam match to FT entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate FT deaminase zinc-binding region. Contains Pfam match to entry FT PF01872 RibD_C, RibD C-terminal domain. Contains PS00903 FT Cytidine and deoxycytidylate deaminases zinc-binding region FT signature." FT /db_xref="GOA:Q9CCP8" FT /db_xref="InterPro:IPR002734" FT /db_xref="UniProtKB/TrEMBL:Q9CCP8" FT /protein_id="CAC30063.1" FT /translation="MNVQTVDSLDAAMRLAVEQSYLVKGATYPNPPVGAVIVDPDGRVV FT GVGATEPAGGDHAEVVALRSAGVTAAGAIAVVTLEPCNHYGKTPPCVNALLEAKVDKVA FT YAIADPNASAGGGAARLTAAGVHVQSGVLADLVTAGPLREWLHKQRTGLPHVTWKYASS FT IDGRSAAADGSSRWLSSEASRADLHRRRATADAIVVGTGTVLADNPTLTARLANGALAD FT RQPLRVVVGMREIPLEANVLNDDSPTMVIRTHDPMEVLKALADRTDVLLEGGPTLAGAF FT LRAGTINRILAYVAPILLGGPVTAVDDVGVPNIARALRWQFDGIDRAGSDLVISLVTR" FT misc_feature 328162..328395 FT /note="Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine FT and deoxycytidylate deaminase zinc-binding region, score FT 114.30, E-value 2.4e-30" FT misc_feature 328255..328371 FT /note="PS00903 Cytidine and deoxycytidylate deaminases FT zinc-binding region signature" FT misc_feature 328549..329058 FT /note="Pfam match to entry PF01872 RibD_C, RibD C-terminal FT domain, score 258.40, E-value 9.8e-74" FT CDS complement(329150..330679) FT /transl_table=11 FT /gene="ML0556" FT /product="putative integral membrane drug transport FT protein" FT /note="Similar to M. tuberculosis Rv1410c, probable drug FT resistance transporter, TR:P71678 (EMBL:AL123456) (518 aa); FT Fasta score E(): 0, 82.0% identity in 506 aa overlap. FT Similar to many e.g. Bacillus subtilis bmr3, multidrug FT transporter, TR:P96712 (EMBL:D50098) (512 aa); Fasta score FT E(): 5.4e-24, 27.1% identity in 446 aa overlap. Contains FT hydrophobic, probable membrane-spanning regions. Contains FT Pfam match to entry PF00083 sugar_tr, Sugar (and other) FT transporter. Contains PS00216 Sugar transport proteins FT signature 1." FT /note="Similar to ML1562" FT /db_xref="GOA:Q9CCP7" FT /db_xref="InterPro:IPR005829" FT /db_xref="UniProtKB/TrEMBL:Q9CCP7" FT /protein_id="CAC30064.1" FT /translation="MSTRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQ FT MQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLLQVSLAGFAIGSVMTALAGQFGDFH FT MLIAGRTIQGVASGALLPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIV FT WLFSDWRYVFWINIPLTAIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGL FT YNPQPDSKQVLPSYGVPVLVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASV FT AAGAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIALPIGAVLGGWGATKAGDRTMT FT FVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSAT FT LRVVPTAQHGIASAAVVVARMTGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIER FT AAAVADQAKRAYTMMYSDIFMITAIVCVIGALLGLLISSRKEHASEPKVPE" FT misc_feature complement(329459..330640) FT /note="Pfam match to entry PF00083 sugar_tr, Sugar (and FT other) transporter, score -86.10, E-value 0.00086" FT misc_feature complement(330431..330481) FT /note="PS00216 Sugar transport proteins signature 1" FT CDS complement(330679..331395) FT /transl_table=11 FT /gene="lprG" FT /gene_synonym="ML0557" FT /product="putative lipoprotein" FT /note="Similar to M. tuberculosis lprG, Rv1411c, putative FT lipoprotein, SW:LPRG_MYCTU (P71679) (236 aa); Fasta score FT E(): 0, 68.1% identity in 238 aa overlap and to other M. FT tuberculosis lipoproteins. 27 kDa antigen (Mycobacterium FT bovis). Contains probable N-terminal signal sequence. FT Contains PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT /note="Similar to ML0136" FT /db_xref="GOA:Q9CCP6" FT /db_xref="InterPro:IPR009830" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCP6" FT /protein_id="CAC30065.1" FT /translation="MQAPKHHRRLFAVLATLNTATAVIAGCSSGSNLSSGPLPDATTWV FT KQATDITKNVTSAHLVLSVNGKITGLPVKTLTGDLTTHPNTVASGNATITLDGADLNAN FT FVVVDGELYATLTPSKWSDFGKASDIYDVASILNPDAGLANVLANFTGAKTEGRDSING FT QSAVRISGNVSADAVNKIAPPFNATQPMPATVWIQETGDHQLAQIRIDNKSSGNSVQMT FT LSNWDEPVQVTKPQVS" FT misc_feature complement(331315..331347) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 331552..332175 FT /transl_table=11 FT /gene="ribC" FT /gene_synonym="ML0558" FT /product="putative riboflavin synthase [alpha] chain" FT /EC_number="2.5.1.9" FT /note="Similar to M. tuberculosis ribC, Rv1412, riboflavin FT synthase [alpha] chain, SW:RISA_MYCTU (P71680) (201 aa); FT Fasta score E(): 0, 82.4% identity in 199 aa overlap. FT Similar to many e.g. Bacillus subtilis ribE, riboflavin FT synthase alpha chain, SW:RISA_BACSU (P16440) (215 aa); FT Fasta score E(): 9.5e-28, 43.4% identity in 198 aa overlap. FT Contains 2 Pfam matches to entry PF00677 Lum_binding, FT Lumazine binding domain. Contains 2 x PS00693 Riboflavin FT synthase alpha chain family signature." FT /db_xref="GOA:Q9CCP5" FT /db_xref="HSSP:1I8D" FT /db_xref="InterPro:IPR001783" FT /db_xref="UniProtKB/TrEMBL:Q9CCP5" FT /protein_id="CAC30066.1" FT /translation="MFTGIVEELGEVVGRDAHADAARLIIRGRTVTADAGHGDSIAVNG FT VCLTVVEVLPDGQFSADVMAETLHRSNLGELRVGNRVNLERAVAINSRLGGHIVQGHVD FT GTGEVVARTLSDHWEVVRIEVPPAVARYFVEKGSITVDGISLTVSGLGAEPRDWLEVSL FT IPTTRELTTLGRTPLGTQVNLEVDVIAKYVERLLQSVPTGDLTR" FT misc_feature 331585..331812 FT /note="Pfam match to entry PF00677 Lum_binding, Lumazine FT binding domain, score 59.90, E-value 5.6e-14" FT misc_feature 331768..331806 FT /note="PS00693 Riboflavin synthase alpha chain family FT signature" FT misc_feature 331849..332112 FT /note="Pfam match to entry PF00677 Lum_binding, Lumazine FT binding domain, score 77.10, E-value 3.7e-19" FT misc_feature 332068..332106 FT /note="PS00693 Riboflavin synthase alpha chain family FT signature" FT CDS 332302..333609 FT /transl_table=11 FT /gene="ribA" FT /gene_synonym="ML0559" FT /product="putative GTP cyclohydrolase FT II/3,4-dihydroxy-2-butanone-4-phosphate synthase" FT /EC_number="3.5.4.25" FT /note="Similar to M. tuberculosis ribA2, Rv1415, putative FT GTP cyclohydrolase II, SW:GCH2_MYCTU (P71684) (425 aa); FT Fasta score E(): 0, 93.4% identity in 425 aa overlap. FT Similar to many e.g. Actinobacillus pleuropneumoniae ribA, FT riboflavin biosynthesis protein, SW:GCH2_ACTPL (P50855) FT (401 aa); Fasta score E(): 0, 52.4% identity in 401 aa FT overlap. Contains Pfam match to entry PF00926 FT DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate FT synthase. Contains Pfam match to entry PF00925 FT GTP_cyclohydro2, GTP cyclohydrolase II." FT /db_xref="GOA:Q9CCP4" FT /db_xref="HSSP:1G58" FT /db_xref="InterPro:IPR000926" FT /db_xref="UniProtKB/TrEMBL:Q9CCP4" FT /protein_id="CAC30067.1" FT /translation="MGPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLI FT FAAEKATLEMVAFMVRYTSGYLCAPLDGAICDRLGLLPMFAVNQDKHGTAYTVTVDARN FT GVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLAR FT LAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDLALITIADLIAWRRKHEKHIERV FT AEARIPTRHGEFRAIGYTSIYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFG FT SRRCDCGTQLDAAMAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANI FT KLGFPSDARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANAD FT NIRYLMTKRDKMGHDLGGLDDFHESNYFPGEFGGAL" FT misc_feature 332350..332943 FT /note="Pfam match to entry PF00926 DHBP_synthase, FT 3,4-dihydroxy-2-butanone 4-phosphate synthase, score FT 455.00, E-value 6.3e-133" FT misc_feature 332950..333477 FT /note="Pfam match to entry PF00925 GTP_cyclohydro2, GTP FT cyclohydrolase II, score 402.80, E-value 3.3e-117" FT CDS 333606..334088 FT /transl_table=11 FT /gene="ribH" FT /gene_synonym="ML0560" FT /product="6,7-dimethyl-8-ribityllumazine synthase" FT /EC_number="2.5.1.9" FT /note="Similar to M. tuberculosis ribH, Rv1416, riboflavin FT synthase [beta] chain, SW:RISB_MYCTU (P71685) (154 aa); FT Fasta score E(): 0, 78.9% identity in 152 aa overlap. FT Similar to many e.g. Actinobacillus pleuropneumoniae ribH, FT 6,7-dimethyl-8-ribityllumazine synthase, SW:RISB_ACTPL FT (P50856) (153 aa); Fasta score E(): 1.7e-15, 44.3% identity FT in 140 aa overlap. Contains Pfam match to entry PF00885 FT DMRL_synthase, 6,7-dimethyl-8-ribityllumazine synthase." FT /db_xref="GOA:Q9CCP3" FT /db_xref="HSSP:1HQK" FT /db_xref="InterPro:IPR002180" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCP3" FT /protein_id="CAC30068.1" FT /translation="MSGGAGIPEVPGIDASGLRLGIVASTWHSRICDALLAGARKVAAD FT SGIDGPTVVRVLGAIEIPVVVQELARHHDAVVALGVVIRGDTPHFDYVCNSVTQGLTRI FT ALDTSTPVGNGVLTTNTEKQALDRAGLPTSAEDKGAQAAAAALTTALTLLNLRSRI" FT misc_feature 333648..334073 FT /note="Pfam match to entry PF00885 DMRL_synthase, FT 6,7-dimethyl-8-ribityllumazine synthase, score 250.90, FT E-value 1.7e-71" FT CDS 334085..334555 FT /transl_table=11 FT /gene="ML0561" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv1417, hypothetical FT protein, SW:YE17_MYCTU (P71686) (154 aa); Fasta score E(): FT 0, 75.5% identity in 143 aa overlap. Similar to other FT hypothetical proteins e.g. Corynebacterium ammoniagenes FT ribX, hypothetical protein, TR:O24754 (EMBL:AB003693) (184 FT aa); Fasta score E(): 2.1e-15, 34.5% identity in 148 aa FT overlap. Contains hydrophobic, possible membrane-spanning FT regions." FT /db_xref="InterPro:IPR019692" FT /db_xref="UniProtKB/TrEMBL:Q9CCP2" FT /protein_id="CAC30069.1" FT /translation="MTAQLDRDDWDVELRPYWTPLFAYAAAFLIAAAHITVGLLLRIKS FT SGVVFRTADQVAIGALGLVIASAVLLLTRPRLRVGAAGLLVRNIMFYRIIPWSHVVDVS FT FPLGSHWARIDLPDDEYIPLMAIQAVDKERAVEAMDAVRALLARYRAGPYGP" FT CDS 334870..336813 FT /transl_table=11 FT /gene="uvrC" FT /gene_synonym="ML0562" FT /product="putative excinuclease ABC subunit C" FT /note="Similar to M. tuberculosis uvrC, Rv1420, FT excinuclease ABC subunit C, SW:UVRC_MYCTU (P71689) (646 FT aa); Fasta score E(): 0, 87.6% identity in 646 aa overlap. FT Similar to many e.g. Escherichia coli uvrC, excinuclease FT ABC subunit C, SW:UVRC_ECOLI (P07028) (231 aa); BlastP FT Expect 8.9. Contains Pfam match to entry PF01541 FT Exci_endo_N, Endo/excinuclease amino terminal domain. FT Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. FT Contains Pfam match to entry PF00633 HHH, FT Helix-hairpin-helix motif." FT /db_xref="GOA:Q9CCP1" FT /db_xref="InterPro:IPR000305" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCP1" FT /protein_id="CAC30070.1" FT /translation="MPDPATYRPATGSIPVEPGVYRFRDPYGRVIYVGKAKSLRSRLAS FT YFADVANLHPRTRQMVTIAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNIRYRDDKSYP FT VLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSPGVFKR FT HKQIDRPCLLGYIDKCAAPCVGRVGAEQHSQIVADFCDFLSGKTDRYARDLERKMSAAA FT EQLDFERAARLRDDLFALKRAMEKQAVVFGDGTDADVVAFAYDELEVAVQVFHVRGGRV FT RGQRGWIVEKSDDPGDTGEEQLVEQFLAQFYGEQAELDFVADESANPVPREVLVPCLPS FT NADELASWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEELQQHKLKRASDFNSRSAA FT LQNIQDTLGLSYAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIRKAAGNG FT RSDDVASIAEVTRRRFLQHLHDQNDTNLLSPEGKSHRFAYPPNLYVVDGGAPQVNAAST FT VLEELGIIDVAVIGLAKRLEEVWVPFEPYPVIMPRNSEALFLLQRVRDEAHRFAITYHR FT SKRSKRMTASALDSVPGLGAHRRKALVTHFGSIARLKDATVEQITAVPGIGVATATAVL FT EALRPDSSEASE" FT misc_feature 334918..335190 FT /note="Pfam match to entry PF01541 Exci_endo_N, FT Endo/excinuclease amino terminal domain, score 55.10, FT E-value 1.5e-12" FT misc_feature 335491..335598 FT /note="Pfam match to entry PF02151 UVR, UvrB/uvrC motif, FT score 42.80, E-value 7.7e-09" FT misc_feature 336691..336780 FT /note="Pfam match to entry PF00633 HHH, Helix-hairpin-helix FT motif., score 28.10, E-value 0.00021" FT CDS 336810..337706 FT /transl_table=11 FT /gene="ML0563" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1421, conserved FT hypothetical protein, SW:YE21_MYCTU (P71690) (301 aa); FT Fasta score E(): 0, 92.3% identity in 285 aa overlap. FT Conserved in many bacteria." FT /db_xref="GOA:Q9CCP0" FT /db_xref="InterPro:IPR005337" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCP0" FT /protein_id="CAC30071.1" FT /translation="MSGNNHPGDASAEIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNL FT PPQLITWMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRRELATRNIIPRVVFMEAS FT DDMLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSALSVPGLRESI FT ERAFGGDASATTSVTVESFGFKYGLPMDADIVMDVRFLPNPHWVDELRSLTGQHSAVRD FT YVLGQPGAAEFLRTYRRLLSLVVDGYRREGKRYMTVAIGCTGGKHRSVAIAEALMGLLQ FT SDLQLSVRVLHRDLGRE" FT CDS 337703..338782 FT /transl_table=11 FT /gene="ML0564" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1422, conserved FT hypothetical protein, SW:YE22_MYCTU (P71691) (342 aa); FT Fasta score E(): 0, 85.7% identity in 350 aa overlap. FT Conserved in many bacteria." FT /db_xref="InterPro:IPR010119" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCN9" FT /protein_id="CAC30072.1" FT /translation="MISPGSPPSIVALGGGHGLYVTLSAARRLTPYVTAIVTVADDGGS FT SGRLRSELGVVPPGDLRMALAALASDSPYGRLWATILQHRFGGSGALAGHPIGNLMLAG FT LSEVLADPVAALDEVGRILGVKGRVLPMCPIALQIEADVSGLEADPRIFRLIRGQVAIA FT STPGKVRRVRLLPVDPPATRQAVDAIMAANLVVLGPGSWFTSVIPHVLVPGLVTALRAT FT TARRALVLNLAAGPGETAGFSVERHLHVLAQHAPGFTVHDIIIDADRVPNNREREQLRR FT AATLLQAEVHFVDVARPGTSLHDPGKLATALDGVRVGNQDSSAPTVAATEQIRLDGKRP FT QTGVNGPVGKGPRGDDAWR" FT CDS 338779..339756 FT /transl_table=11 FT /gene="ML0565" FT /product="putative transcriptional regulator" FT /note="Similar to M. tuberculosis Rv1423, putative FT transcriptional regulator, TR:P71692 (EMBL:AL123456) (325 FT aa); Fasta score E(): 0, 92.0% identity in 325 aa overlap. FT Similar to Streptomyces coelicolor whiA, sporulation FT regulatory protein, TR:Q9S4Y1 (EMBL:AF106003) (330 aa); FT Fasta score E(): 0, 67.6% identity in 324 aa overlap." FT /db_xref="InterPro:IPR018478" FT /db_xref="UniProtKB/Swiss-Prot:Q9CCN8" FT /protein_id="CAC30073.1" FT /translation="MTIEVKDELSRLAVKSISARRAEVTSLLRFAGGLHIVGGRVVIEA FT EVDLENIARRLRKDIFDLYGYNAVVHVLSASGIRKSVRYVLRVANDGEALARQTGLLDM FT RGRPVRGLPAQVVGGSLIDAEAVWRGAFLAHGSLTEPGRSSALEVSCPGLEAALALVGA FT ARKLGVNAKAREVRGADRVVVRDGEAIGVLLTRMGAQDTRLVWEERRMRREVRATANRL FT ANFDDANLRRSARAAIAAAARAERALEILGDTVPDHLASAGKLRVEYRQASLEELGRLA FT DPPMTKDAVAGRIRRLLSMADRKAKVEGIPDTESAVTPDLLEDA" FT CDS 339866..340275 FT /pseudo FT /transl_table=11 FT /gene="ML0566" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1425 (Best blastx score 264)" FT CDS 340845..342398 FT /pseudo FT /transl_table=11 FT /gene="ML0567" FT /product="possible transporter (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1431 (Best blastx score 550)" FT RBS 342803..342806 FT /note="possible RBS" FT CDS 342813..343406 FT /transl_table=11 FT /gene="ML0568" FT /product="hypothetical protein" FT /note="Similar to M. tuberculosis Rv1435c, hypothetical FT protein, TR:O06823 (EMBL:AL123456) (202 aa); Fasta score FT E(): 1.7e-07, 38.9% identity in 203 aa overlap. Pro- and FT Val-rich protein." FT /db_xref="UniProtKB/TrEMBL:Q9CCN7" FT /protein_id="CAC30076.1" FT /translation="MKVFDRFNTAILVSAGLCGAALAFSPSAAAAPLSMPTGGPTCIEQ FT MAGLGAVPAAVPAVLPGPVAGAVPSVPVVPSGGFPPVVPPGGFPPVVPPGGFLPVVPPG FT GFPPVVPPGGFPPVVPPGVAPAVGPLLAEDSAALGSGILAGKGVPTASPQAALSGLVVL FT PGPPASVEAPPAAAPVVAAATPLLCCGEAAPPVR" FT repeat_region 343053..343177 FT /note="5.6 copies of 27 bp direct repeat, Consensus FT CCGGTGGTGCCGCCTGGTGGGTTTCCC" XX SQ Sequence 344050 BP; 67794 A; 94517 C; 104970 G; 76769 T; 0 other; gtgacgcttc caacccaggg atcggaccga ctttgtgttt gcgtaggttc ccctgtgtat 60 tgttgtaagg gcagtgatct acgtcttcgc agttctgacg aaaggttcag gggaactgat 120 atttacgacg ttcttagcgc cgacgcgggc agttttaaca agctccgatc ggactggaca 180 tggcggcatc atctggttcc cattggaggc accggttaat gcgcgtggcg tgcggatcgc 240 tcgctaaacg aagcttcaac gcacgtcggg taacgcggcg acatcgcttt gggatgcaat 300 gtcccagaaa cggcttccgc acgttagatt cttcgccggg cccccatagc ccaattggca 360 gaggcagcgg acttaaaatc cgtcaagtgt cggttcgagt ccgactgggg gcactggtaa 420 cacgcaggct gtgccgatgc aaccggaagg ttggagatta ggcttgcggt gctgttggca 480 tggcgcaagc gtcaatctca gctgtgtctg cgaaggtgat ggccactagc gcattctagg 540 agttggtgtc aacgatcggt gtggcagcag catagcgatc acccagctgc atccaaagca 600 ggtgggacgt tatgtcaaac gagccgattc cttcgcaaac aggtcagaaa catggggagg 660 gggtattctg actgtcatat ttggcattgg tgccggggtt gactggcaac gtcatattag 720 agatgtcgct ttgctggtgg cgcctgggcc tggaagttca gggttagtta gctggcgagc 780 gcggcggctg cgtggggagg gggtaatggg gactgccttg atcggtgaag tgtctaatcc 840 atctagggtg ccttgacgac accaagtatc accgtacatg cgaagtaccg gccatcgagg 900 ggtgaagcct ttgttctcgt aaaacgagta gaagtagtgc gctcgataac tctctttggc 960 gtaacacaag tcgacgtcat cttcggactg tgagcggaca gcattgtcaa gcaagacgct 1020 tcggacatct cgccttggtt ttctattgcg atatagagcg cgttgatttt gagattatgg 1080 gggttaactg gctctggtcc aaagatgctt atgccgatga gcctgttagt cggtctcggc 1140 aagccacatt gactacccaa gtcgatttag cttgtgggca tgcccgtcgt agctccagtt 1200 ttgctcactg aacatgtcaa gcacataggg tgtcaggatt ccggcgtagg actgtcgcct 1260 actcggttag tgcatcttca cgacgcggtc gtagtctggg ggctccgctt gccggatctg 1320 gatatcgtcg ggaatctgtg ttgcgctaac tacgctagtt acttggttat ccgttggtaa 1380 ggttcaaaca cccggtcacc ggtaatctgt tgggcatgta attgaaatcg cttgtccagc 1440 aacgggtaat aagtctgttt ggcagctaac gctgccgcat tgtttgtacc tagacgccaa 1500 tcggggtcaa tgcccatgca ctgactcagt gtgagcgtgc tgtttggctt tgcgccgtgg 1560 atcgtctatt ggggtgctgg ttggtaacgt cccctttacc gctgaagtgt tggtagcatt 1620 ggcaatcgct gtcgcggcta taggctgagt gacagcgtca ccggaaaacg ccaacatgcg 1680 ctcggaatcg agtactttcc aaagtttttg gtgctgacag ttttggtatt tgcgctcacc 1740 gagtcgttca ccaccagctg gataaagcag tttagcatcg ccgggatctt gtgggtggtg 1800 ctcattggcc agctgaccgg cgaactgttt gtgcgtgact tcgcagccgc ggaacggcct 1860 gacgacgtgg tcaagactca gctgttcgcc cggatcgtta cgctactcac ctggatttag 1920 ggtgccgctt tagccggcat tacagtctcg tcggcgatcc caccgatcgt gcagggcctg 1980 gcgggaacct acgtcactat cctagatact aggacttcgt tgtaccttcg tctgctaagg 2040 ggttattctg ttttcgttgt ttggtgtggc ggtgataacg tcgcgttttt ttgctcgacc 2100 ggatgctagc cgaagtcggc gatctctcct gggaagtatc gttcgttgcc tacgacgaag 2160 ccaccatcga tgcgcaggaa catgccaaac gcgaagtcgg cgcaagtata acttaggcct 2220 acgacgtgac ggtcggaggg atggaaacac cgctgaccgg ggacgattcc cgaaaattgt 2280 ggccctagat cgacaaggtc cgcgagtggc gacaggagac aacaccccaa ctcggtaccg 2340 tttccaccaa aacgtgctac agtcgatctg ctccgaagac ctgttcagcg gctccgccgc 2400 ttggatatgt ttacgcttgg atatgtttag ttgcggcggg gtacacccgg atatctgtgt 2460 gcgttccaca ttttgttgcg accaaacaac ataggggcac cgctgtgaac gcacccaaca 2520 gatgctattc gcggagaaac agtcaccatt accaataatg gccgcgacca aatcgaggct 2580 taccgggccg agcgcgttag cattgaaccg cacagcgatt gtgcgtgatc gtccgaactc 2640 tctttcctcc aaggaccagt aggtgacata tgaccaccgg cataattttt ggggggaact 2700 gtaactgccc tcaaatggta gctgtgcgaa gaaaaagcca gttcgcacct cttcgaattc 2760 gttgctatct tgactcggca ctagttgtca ctactacaca catagcacat acgcgttatg 2820 tgtggtaaaa ttttcatgat ctttattaac tatatggcac tggcggatgg ctgcgcgggg 2880 ttcttgcgcg atgagagcca cccacagtgt gtgtagttgt ggccgtcgtg gctgcacttg 2940 gcgtttgggg cttgccagag ccaccagtca gccgcgcgag tgtttgacat cgagggcgac 3000 cgccccgtag tgggcaccgt gcgattcgac agggatcggc tgcggtgggt cgaaaaggac 3060 aagccgatct atggtccctc acgcaacccg cattcgtaga tcgacggtcg ccgcacgcac 3120 cgccatgttc ggggagagct ggacagtcat cttcgccgat actcgatcta ctgtcctgct 3180 attcgaaacc attttaccaa cgagggatta tatcgatccg ggcgatgccg ccttcgaaca 3240 tgtagaaccc agctcgatgc agaagctgta tccatacacg gggggggggc tattgggcta 3300 ctggtcagtg tgggagagac accagatgta tcctgtttcc gggtctggcg tcgacgtaat 3360 agtataccat tacttcctgt tacgtcgatc gctagcccgg tgtccttcta taacgagaaa 3420 ttcgatatta ttgtccgtcg atagtagggt cccgctgcga tagcgtaacc gattcagctg 3480 attgccggcc ggttgttcgt cgtgcgggta atagatcgag tacgtcgcgc cgagccgtca 3540 ttgctggtgt tgccacctgg aagagcggcg acggcaaggt ctggttctct cagtgcagaa 3600 tctggataga caacgctgtt tcgacggtta gtggtgaaga gtacctacga taggggaaag 3660 ctggttgacg tagtcgtttc cggtgcggac tcaaacggtc taatgatcgc atgtgaactg 3720 gcgttgtgcg gcgtgcaacc gattgtgccg gattgtttcg ccaatcccgg caatagagtg 3780 caaagccaat gactttggcg gctagttaat tcggatgatt gatatgcgtg ggctctatca 3840 cgagttcggt ggttagtctg gtgcacatca gccggttgtg ggtggtgtgt gcgtcgtgat 3900 tccattggtt tatgctcagg agctaggcaa tccgatgcat tgtgttgccg atgtggcagc 3960 tacggtttag tgcggctact ggaacgatgc actcgcagtc tcggcgtcgc cgtccgctgg 4020 cgtcgcgaac tcacccagtt ggtcggggac agcggcatca cgttggtggt tgtcggacct 4080 gacggaggct atacactcac catcaggtac atactcgccg ccgacggctc gcacagctgt 4140 gtccgcaaga acgttaggat cgagttcccc gagaataccg cttctgtcgt tattcatgcc 4200 agtaacgtgc acattcccga tcaccttcgt gccgtcgaca gcgttgtcgg cgtcttcggg 4260 tttggcgtag gcagtatcct ttatatctgt tttcggtccc ttgtcatccg ggcaccaccg 4320 atttgagcaa ggggtgttgg tgcttttgct cgacctgtag ctggggtgct cgctggtcgt 4380 gacgatggag ttcggcgacg atccggttcc cggcaaggct accgtgactt tgctaatgct 4440 ctagaacacc ctgtgtcggc tacttgctcg attaccgggc tcgctgggtg gtgactactg 4500 gcggttgtgt tgaggttaat gttagcgcgg actcgttgtg ggggtggagt aaagggtggt 4560 gggtcagtgt attggcgggt cggtgcgtca ggtcgcaaag gtcggtatcg atgccgtggt 4620 gatgcgggta tgagagtcgt ttcgaggtct tggtctcacg ctggggttgt acagcgattc 4680 tgtggtaggg cgttgtcttg tggttgatca tggccgcagt gatcacatca gtgctgtggt 4740 ccttggatag gtgtagcagc tgcacgaatc cgctacttgt gttcggccag ggcgccgatt 4800 tgggggtcta atttttgccg atgattacat catccgccca atgctatgag gttagagcac 4860 cacacggtcg tgtagttttc gcgggacgtg cactggtggt ggccatacct agagaataat 4920 ggtggtgccc ggttttagcg tgctgtgccc tcagcgtgcg gaacatccac ccagtgcgca 4980 catgttggtt gagcttggac tcgatgttga agtgttttat aggacacctg catctttcgg 5040 gccggtcggg ataggttttg ggccaacacc cccacaattt gttcgggact gtacttcttg 5100 gccagcacac atgtctatct ccgtacgcag ctgcccacaa cgctcacctt gccggccttt 5160 aaagccactg gcccactgct cactgcatag ctaagcaata caagctcagt aacccgattg 5220 agcgtcttag ccagcatagt tggtgtcgaa tcagtgcaac ccccaaagca acccgcaaac 5280 acgcgggccc cacccttgct ggtgatctca cgcacgatcc ccacccccac ccaacccaaa 5340 cgaacggtta acgatcgatc acatcaactc acaacactgc aacacaccgc caccctttac 5400 tccaccccca caacagaaca tgcacacaaa gtacaattca accccgagag agcgctacgt 5460 tatgcggtct cggtgctctg cggtcaacgt ggtcaggaaa gacagtcact tacgtgcatt 5520 acaccccacc agaaccccag aatcatgaaa tactgaggct ggaaacggta tctggcgttg 5580 agtggcgcgc tccagtcgct ggcccgcgtg cattcctagg cgactgatcg tggagaaaat 5640 ctcatacctc tatacttttg tttctgtcct acaacgtagc tgacagtata catggtgcat 5700 gtcctgcttg aatgcattgt tgtcgatcga aagactattt acgaatgtcc agtcattatg 5760 aaggaaaatc cgaggtagag attatcccta cctaaccgct gacgacatca aggaatactt 5820 tagaaatatt acgcgacagc gcaagccgat cacgcgatcc ggatcccgtc gtagtctgtg 5880 cgtttctgat cgatacgcag tttccgccaa cgttagttca gacgcttatc acgtctccgg 5940 gcatgtgaag gaaatcagac tgggcgatgc atcagatcgg acatctgacg ctatgccatc 6000 cagtacgacg ccgtgctcgt cacaaaagat gagggcttct ctgacatgtt tctcctaaga 6060 ataagaacca atgcttccgg cgtggtgtgt ggatccgtgt cggtaacacg ctacgccaag 6120 cactgcttaa atggtttgag ccgacgattc accgatatcg ctaagctgga agataaggat 6180 aacagtatta tcgaattgca ttgaacagta tggctttagg taatgtcagc cgtactcgaa 6240 acttcatcaa ttctgttcaa taattctgtt caatagtcaa aatcagacac cgaagtccct 6300 gttaccacac tccatactcc agcctttcac gaatatgaaa aataacatat caatctttgc 6360 caacaagaag ttgtccactt agatagtagg aaaaggcgat actttgctta ttataaattg 6420 tgaatgccag cgtagaattc ctcgaaaatc ctacgttgac aatctagtta agattagcta 6480 aagccactat acttatccac acctatccac ttcttcgtta aggcgttacg acgagtgagt 6540 ttcccgcttt acgtggttcc atgaccgccg ggccgatgcc cagcagacat gccgcgtaca 6600 gcccgacaag cactacgcct gtacccaccg cctaaccggc gtgacgctta accaaaaccg 6660 gcgcgggcgc gcataccctg cctaaactag gtattgtagg caagcctaac gaggtaccac 6720 caaccctgta gaaggtgctg cacttttcga tgtcccatat ctcccttccg ggagcggaaa 6780 ctgacgcacc ttggcacagg tacctcgtca ttttacgacg atcccaggca actcctggtc 6840 gacgagatca ccgaatccgt cgggcacagt agccgaactc gacaactctt acaagtaacg 6900 tcgtatccgc tgaacaacgt ggacaacacg cttagacttc cattaagaat ttcgtcgtat 6960 atgtgagcac gtacatacag tcacgagtga tggccagttt ttcgttggtt ggcaccacaa 7020 ggacagcaat cggtgagctg tcctgagaaa tgcacacaat cccccagctt tgggccttga 7080 gatcaaattc cagccctagt caagcatgat gtcgagtccc gctatgctga gtaacgcatc 7140 gctacgcacc gtcgggttat tttcgtcgat ccctacggta aagctcactg catcagtatg 7200 tcccagcatc gcaaggtagg gtccgatgta cttaggtaac cgattacgat gaccacatcg 7260 tgtgctaaaa ttatgctgca ctgcagcttg attctataca tctcttgtgg tggagaggaa 7320 atagcgcttc ccggttaacc tgccggctcc gactggtgat tgagcatgga ctcgatctcg 7380 tcgacatctg tctgagcgct gagccacaac tagctgatga cgctaggggg ctatatgcat 7440 caccgcgggt gttcataacc aaactctcca gcggaggcag gatcacggaa gtgtcgagta 7500 gcctactgac tgcgacctcc taccaaggct ccgggactta gttgcaacac aatctgatta 7560 agactgtggt acgaactgtc caggaaagcg gcggccggcc cgctcactta ccgatgcgac 7620 gtgccataaa atccatagcg gcgaatctac tatcgctcga ccagccgacg atcaatggcg 7680 tatgttgcag ccgctggtta tagatcgtga aagaaaacta tggcgaacac cacgatacgc 7740 ggaatgctgt gcggccactt tcgtgtcacc tcgagttctt gcaccgcaga cgtcttatgc 7800 agcgtggaca agaggctggc tttactctcg ttgccgacgt acaccacccg atgcccaacc 7860 gccaccagcc tgcagttctg caggtcaaca cccgatcgag tatgttgctg caagcaatag 7920 gtgaccatgg gcagtatggc agcagtcggg atcgggatgg caagctgggt caacaggtcc 7980 gcaacatcaa cgtggcggta catcagttcc agtgcagatc gaccttgtgc tggcacggtt 8040 gccgcaagcc gaggtggcca cgctggccgt tctgtaggta cccagggtgg tggtgatcgg 8100 caacctcagc cgcagccccg ataccaacgc cgcgatcgac ggctgcagtt cgaacacacc 8160 gtttaggatg atgcacgaaa actccagaaa acctttcggc ggaatgggaa ctggttacgg 8220 caagcgccac atcagagcgg tcactggggt aatgaccgtc atcccatcac accgccgttc 8280 cagcacatgg tcggcgggca tcctggcgac caacatgtcg gtgaccgcgc aatcccacag 8340 agacacgtca ccgctgactg gcgtcccggt cacggccatc ttcagttcag tcacgatcga 8400 cgtcgccaac aggatccggg ctggacagcg tatagctggg agggacgaac acgcgcaacg 8460 cctcgcgcac ggactcaagt tgtaccggtg ggccaccacc atcgaggcgt gggcacgcgg 8520 ggtggccagt ctcttaggaa caccaccgac aagacaacac ctacgaaagg tggtcggggc 8580 tgcgggcatt ggcactcacc gcgagcagca taggcgctcc ctagttgacc gcgatgcgaa 8640 cgttgaccga aagtttcagt gggataagct cccactccca ggtcaaggta atcgttgccg 8700 acaatcacga cgatgtcgca tgcctcggcc atcgcgttat actgtcgata agtcacacta 8760 aagcaccagt tgatagagca aacccggggc ggtgtgagcc agcagtaatt ccagagcgta 8820 atgtaacaga tatcattgaa ccgagtgatc ggccaaacca cgccgacttt agcgatcgtg 8880 gtgtgcaagt aggcttcggg gtcgtcaagg ggtaccgatc tcgggatgtc cagtgcgatc 8940 gtcaccttgc cggacgccga ttcaggcgcg gcaatcgagg tcgccggatt cggcggcagc 9000 ctgccttcag cccagccgcc gcagccgggg cgccagatct ttctcaaaca actcgaggaa 9060 gcggcgctgg ttatgaccgg gagcatgaaa caccagatga ttgaggcccc acgtcacata 9120 ttgaccaacc cttgctacgg cttcatcagg atccgacacc acgatccagc gcttggcaac 9180 ctgctcgatc ggcagtgcgt cggcgacctt ctccatctcg atcgggtcgt caatgctgtg 9240 cttctgctcg gcggccagcg atagcggcgc ccagaaccgg atgttggaca gagcctgctc 9300 gggatcgggg tcgtaggaca tcttgatttc gatcatcttg tcgatgtcgt cagcatctct 9360 gccagccact gctgcccctt ctaggacggc aggaataagc ttttcagtgt atagttcctc 9420 ccccttgcca gaggtgcaga cgaagccttc gccggcgcga ccggcatatt tggccacctc 9480 cgggccacct gcggcaatgt agattggcac accgccttcg ggtacgtcgt aaatcgacgc 9540 acctttgagc tggtaatagt cgccatcgaa gtcgacacga tcaccgcgcc acagctcccg 9600 cattagccgc acagattcac gcagccgggc gaaccgctcc ttgaactccg gccaggcacc 9660 ctgatacccg gtggcaacct cgttaagcgc ctcaccagtg ccaactccga gaaagacccg 9720 gttcggatag aggcagccca tggtggcgaa ggcctgccct atgacagcag ggttgtagcg 9780 aaacgtcggg gtaagtaccg aggtacccag cagaatccgg ttagtgcgtt caccaactgc 9840 agtcatccac gacagtgaga atgacgcgtg cccgccctgg tgacgccacg gctggaaatg 9900 atcgctgacg gtagcgctgt ccatcccgtg agcttcggcg gcaaccccga gttcgactag 9960 ttcacgcggt gcgaattgtt cagctgacgc cttgtatcca agtctcaatt cagccattag 10020 ttctttctac tcctcgtggc cgattgcaag cgcagctgag ccgggcgcag caggtctcca 10080 cacatcagac ttagactctc cgacatggca gcggcgactc tcttccaggt caccgattcg 10140 gtgcattttg ctcgcggcga cgcggtgaac tgggcactag tggccgatga cactggcgtc 10200 atgttgatcg acaccggcta tcctggcgac cgcgatgacg tggtggcctc actgcgccaa 10260 cttggctatg aggccggcga tgtgcgcgcc attctgttga cccacgcaca catcgaccat 10320 atgggttcag cgatctggtt cgccagcaaa caccgtactc cagtatattg ccatgccgac 10380 gaggttggac acaccaaacg ggagtactta gaacaggttt cgttgctcaa tatcgctatg 10440 cgtgtgtggc agccacggtg ggcgatctgg tccggtcacg tgcttcgtag tggcggcctg 10500 atccgcggcg gtatcccgac cgcccagccg ctgactgcgg agacggccgc cgggctgccg 10560 ggtcacccga tggctatttt cactccgggg cacaccggcg ggcattgctc atatgtcgtc 10620 gacggcgtgc tgatcagtgg tgacgcactt ataaccggcc atccgctgct gcgtcaccgt 10680 gggccgcagc tactgacggc cgtgttcagc catagccaga agcagtgtct gcgcagcctg 10740 gacgcgctgg gcctgctgga aacccgcatc ctggcgcccg gccacggcga gctatggcac 10800 ggccccatcc gcgaggccac ggaagcggcg ttgaaacaag ccggagcgct aacgcgttga 10860 gcgacgcctc aagatcagct caacgacagc acgccaacca aggaacaatg ccgcggtagt 10920 cgatgcagct accaccatga aattcgcgac cacacctgcg gagctagctt tgcgcaacgc 10980 cacaccgacc accacggtgc acaaccagac aacgacaccg gtggggacaa cagccgtggg 11040 ccgctgccag ccgcgagacg ccagccaccc aatagccgtt ccggtaagaa acggccacaa 11100 agtaactgcg aggtcggcga cggtgaggcc ttcggcatga ctgcagcgcc cgacagcgca 11160 gaacaccgac acagcgacga tgtcggtagc tagccatgcc agcgcttgcc ccagccgcat 11220 gcagcaagac tacgcgacta tttgacccca ccacggtggt gaacctagat ttagtcggca 11280 ctgaagcacc gattcgcacg cacgacttga gggggcgacc ggcgctggat cggctatcgg 11340 caaggcaata gcgctggcgt tcgccgcaca aggcggccag gtcgtgacta ctgacctcga 11400 cgaggccgca tctacgtcca ccgcggatca gtaaccccag ccggtcaccg cgctgccgat 11460 agatatcgcc gaaccagacc aagtcgccgc cttgcgtgat cgtatccgag ctgaggccgg 11520 cgtaaccaac accgtgatca acacaacctg ttgagacaga aataactaat tcatcaacgc 11580 tacaacagaa ttcgtggaaa aatagcaata atcaactacc tggggccgtt tcaccgctgc 11640 ggtactttca tgctatcgac gttgaggcac acgctggcac gaagggtggg gtcatcgtga 11700 caccgttggc cagattatgg tccatgcgtg tgcccagttc cggccaacat gccgctgttt 11760 cacgcacaac ccatgaaatt gaaagagact cgggtcaaag cgattccgct ccgacatctg 11820 agccagacct agaaggtcaa cgccccggtg tttttcgtgt ctgaagctga atcgtttatt 11880 accggtcagg tgatcagtgc cagcggtggc ttaacaatgg cagcctgccc atatgagggc 11940 acacaagcat cgcccgcctt cgaccgatat aacctgctcg tcctggatgc atctctgcca 12000 agcgataaga tcgttgtgcg cgacgcgggc agaaagtttc cacagagcat gtcaccaata 12060 tactgccgac tggttcgaaa tcgatgacct tccgatccac gaacttgcaa aacagttcag 12120 cggactcagg ctgctaagca tgcacttccc cggagtcgga tgtaataaat gtaataatag 12180 tagctcagcc gtgcactact gcctggcctg tgtaaaacag gagaccactg actccagtat 12240 ctagtcaatg gtctaagtgc aaggctagct ggcgatgtta gcgatccgga aaatgagtcc 12300 gaagagcaga agcagcgctg gcttccggtg aactgctcgg ctgcttcggg ttgaccgagc 12360 ccaacgtcag atacgatcca gccgcgatga aaactcggta acgacgactt ggattggagc 12420 atcaacggtc gcaagatgtg aatcaccaac ggctcggttg ccgataccgt gatcgtgtta 12480 gccagcacca gaaccgccgc ctcaaagtct gatgacgacg cagagttagg ggcacgggcc 12540 taacgacgga gcaacaggca atggggaggc acgatgctgg tcatcaccaa gagttcgttc 12600 ccaaacgtcg aggcgttgtc cggggatctg attagtccgc ctgtcgctgc aacacattaa 12660 ccgtatagtg atagaaattg ttgttgaaca acatcattac attcaaagtg aacgaaagaa 12720 ccagcacagt caggaatcag ccaaggcctt cgaaagctaa ccctgcgctg ccgacgcaac 12780 gagggcattg agcagtgcgg taacgaaaag ttgcacgttg ccaaggtagc aacctagctt 12840 ccccaacgat atctacacct ccgttcacgc cgataagcac ggcttcaagc ctggttggcg 12900 tggctgatgc tgcccccgta tgaccttgat tggccatcgg aaccggatcg ccgcctggtc 12960 tacctaggga cccccttctt gggtctgact cgtgaccaga cgaccttacc agccagatgg 13020 tatagatcta catgcccaga ctggtcatga actgtatggg gaaacacacg cagacacaaa 13080 ggagtgcttg ctaccgacga agaggctgaa cacgccgaac agtcgaccgc cggctaacgg 13140 tcgcagcgtc ctggcggttg gccgaatacg tgtgttctac tagagtagtt ctggatgcca 13200 tccagctccc ggcccaagcg agaacgcact gagtgtacgc gtcttaggag ctctatttcc 13260 ctgagttaac gcaaacgggg catgtcgtga ccggattccg atacaatgcg gattcctcac 13320 cggaagacag ccaggctgtc atgactgagt aaacactcgg catattgatt gttatcaatg 13380 gcgattgccg ctttccgttg agacaggaca gcatccaccc accgtcaagc tagaactggt 13440 actattctcc ccagaacgcc gcggttttca tcgccatctc ctactgcaga tgcaatctga 13500 atacgtacaa actacaccgc tgctcggcaa tcgcgcactg catccggcta gcgctactag 13560 ctcagggcct gatcaatatc agcgatcaga tcggcggcgt cttcgaggcc aatggagatg 13620 cgtaccacac cgtcaccgag cccgatcgca gcacggccct ccgggcccat cgcgcggtga 13680 gtggtagtcg ccgggtgcgt aataagcgat ttaacgtcac cgaagttgtt agaaatatcg 13740 atcagccgca gcctgtccaa tacttcgaag gctcgttgct tagcggcgtc ctccggagaa 13800 ttgagcgcaa aggtcaccac cgttccacca ccagacattt ggcgcttcgc caggtcgtac 13860 tgcggatgcg acaccaaaaa tggatagcgc acccaactca ccgccgggtg cttctccaag 13920 aactctgcaa tacggtgcgc cgaggaatta cagtgatcga ccctaatcgc aagtgtctca 13980 agacctttca gcaatatcca ggcattgaaa gcgctcattg ctgggccagt gtggcgcatc 14040 agcttttgca caggaccgtc gatgtaatcc ctgtcaccca gaatggcacc gcccaacacc 14100 cgcccctggc cgtcgatgtg tttagtacct gaatagatta ccacgtcaac cccgagcggt 14160 aaaccgtgct gcagtagtgg tgtagcaaag gcattgtcca gaacaacttt tgctccagcc 14220 gcgtgagcca actcagtcac ggccgcgata tctaccagcg actgcatcgg attcgagggc 14280 gtctcaaaga acaccgcttg agttggaacc gaaagcgcct gctcccattg cacaaggtct 14340 tcgccgtcga cgaagacggt ctcgacaccc caccgcggta gaatttcatt gcacaccacg 14400 aaacatgacc caaacagact gcgcgcggcc accaaccggt cgccggaggc caacaacgca 14460 cctagcgaag tgaaaaccgc agccatgccg ctcgcggtga cgaacgccgc aggggctccc 14520 tcgatcaggc gtaaccgttc ctcgaacatc gtcacggtag ggttgccgta acgcgaatac 14580 acaaagtggt ccagctcgcc ggtgaacgac ttttctgcaa cgaccgctga ctcgtagacg 14640 taaccagacg tcaagtacat cgtctcggcg gtttcttcga accgggaccg taacaggcca 14700 ccacggacgc ccacggttgc cgcggtgacg ccgtccggca aagccttagg cgtgcgaaca 14760 gagcggtcgt cggtcatttg cgccgggtct ccaacgcacg cggaagctgc ccccacctca 14820 tcactggcgc gagtcacagc tgcttccacg gcaacccaac cgcacgccaa ccggtttcac 14880 cgcggtgacc ttctgcatta agatggccct cgaaaccatc caatatattg tacgatggag 14940 agattcctgc atcggtcgcg acctgcgcag cgcccataga acggtggccc gaacgacaca 15000 ggaacaccac cgggcgttct ccccgctcgg cgtttgctgg cgggatccgc tcctgcaact 15060 cagcgaggaa attcacgttt ggcaggccgt cagatgtgtt ccattcgatg tacaccacct 15120 cgcggccaag acttgacgtg tcgggtaccc cgacgaaccg ccattcagcg tcggtgcgca 15180 catcgaccaa caccgtgtgc gggttgtcac taagcatctt ccatgcctgc agtggggtga 15240 tatcccctgc atagggacgg ttcatttctg tgctcatagg tgttttacct ggtactttcc 15300 atcttctaag gattcctgat atcagcgcct gagaaccacc cccagtgatc ccgagaaggc 15360 aaacccatca atgagcatat ccacggcgtg acgcgtcgtc ctgccgagtg gcggttcccc 15420 gggtagccag aaacatacgg cgtctaatgg atcggctcac accgaaataa atccctctcg 15480 gacctggaac ttatggctgg ccgtatagcc agaacatccg aaggtcgctt tctggcaccc 15540 aaagcgcgca ccagttaggg cgtcggcagt gggctcgttg gtgagctggc agagaccaac 15600 aatcgccgtc gtttcatccc ttgcggtagc tcgacgggcg cttgtgtgtc agtgggatcg 15660 tacttcccgt cagtccccca ctcaccctct cgctcggtcg aatggccccg caggcggagt 15720 caaactatcc atgttgctct gggataggtg cttggcgggg gactggtggc gttcccaacc 15780 taagctatct aagcaacccg cataagagtg aaatcgctcc tcggctcaat ggtgttcgga 15840 ccggcccaat cggattgctc cccaggtggc tggcctccta gcaccgattt cgctagtacc 15900 tgacgtcagc gggtaggacc gagagccccc actaaccgca ggaaggctcg tcgcagatct 15960 gaaagttcgg taagtagaaa tccatgtcct cagtgacaac acaacaggaa atattgagaa 16020 cggccacaag ggatttgggc aaccatcagt tcggcgatga gtgagcccaa gctgccgcta 16080 ttcacaacca gttcgcgtgg ccatgctggc tgcaacgcgg gctcatatgc agacaccaag 16140 cctgtcaacg cggtcgccgt tggcgccggt aggaaatagc catgctggag ttatgaggtt 16200 ccccccggaa atcaagtcca ccagaattat tccggccccg acttgaagcc gatagtcgca 16260 acgacgacag tccggcagaa gctggctacg aaaccgtact caactagcaa cttcttacga 16320 atcagtgatt tctgggctca tcagccaata catagcagtt tccctcgtca ctggcgatgg 16380 ttggccgcgg aggccccttc gtggcgtgga tcaggaacca ccgccgcccc ggccgtggaa 16440 tccgctccca gaccctggcg gcgatgaaag cctaaggcag cccactcgat gacaatgaca 16500 gtacccttat caacaaacgc agcatggtga cctctctgac ccagaccaat atcctgtatc 16560 ctgtgccgaa acaccccggc aatcgcagcc atcgaagccc aatacagcga aatggaggac 16620 caggacatcg gcgcaatagg acagctacgt cggctcttcg acggctactg tcgcggagta 16680 caccagcgac gctacgccgc tgttgagcca agcggtgaca ccgaaaaccg cggcagccgt 16740 gccgggctgg cccacacctc ttctctcaga tcttaacctt ccgatgcacg cacctgttgc 16800 tgtttcgttt ggcagcatgg gcataagcgg cgggacagct agggggagtc cacacacaac 16860 gatgaaatgg ctggccgcga agactccatc ccctgccgtt gatatagtct atcggcgaca 16920 gcggttgccg gtcgagctgc catagtcagc gagcttttgg ttcctcagac ctagggtcgt 16980 tccgtcagcg gtatgcagaa tcccggcgat gttgcccagc gctgcccccg ctataatcga 17040 gcaatatgat tcggacagcc ctcataccgg catcgcgtta gccagtttgg tcggcagagg 17100 catgaccggc cttgcggtcc gggggctgct ccccatcgac ccctgcaccg acgaccccac 17160 ctgggagcca ctcggcagac tccggattag ccatatccaa ctctacgccg ccctcgtcgt 17220 cctcccaacc ttgtcggacg taccagcact gtggtgccgc cgcagaacca acaatcggtt 17280 agccaaaaat acctccttag ggctgcccgg cgagtaaccg caccatcatg ccgttgcctt 17340 cggccaacag catctcgtcg ccgtcgacca gttctgcgga cacaaacgcc ttgcgacctt 17400 cagtcctggt gacccgtccc cgcatcacca atggttcatc gattggggta atcttgcggt 17460 agtccacgtg cagaaaagcc gttcggctga ttgagcggcc tgcagtatac gagatcatgc 17520 cgaacaagtg atcaaacacc aagggtagca caccgccgtg caccgcgtgg ttgaacccga 17580 cgtgaaatcg agtgaagtat ccggtcattt caacactatc ggggccggat cgggtcagtg 17640 tccagggcgg cagcaacaga ctgcccatgc cgggcatgtc aggcacccgc ccagccggcg 17700 ccttaccttc atcggtggca aacgggccta gcaactcgac caaggccacg gcgcggtcgg 17760 ctgcggcata ccatacctcg tcgctggggt cagcggacac tgccaggtcc tgcaagcggc 17820 gcatagttgc cacgaatcga cgaaaaccca caccagggtt agccagttcg tattcaggaa 17880 agccgctata gtgttcgtgt ttagggcgtt ctggaggtag gtcttctggg cgcagggaag 17940 aatagtaggt caccgacggc tcctcaatac atcgcatcgc acgatggtct gatcccgtcc 18000 cggaccgaca cctatgcacg caacctgtgc tccagcaagt tcttccagtc tcaatacgta 18060 gtcacgcgct ttggcgggca ggtcctcgaa ttcccgcgct ccggagatgt cttcccacca 18120 acccggcagc tcctcataga tcggctcggc acgggcgaga tcgctttggg ttatcggcat 18180 atcgtgggtg cgcacaccgg cgatctgata gccgacgcag accggcaccg tttccaagct 18240 ggacagcacg tcaagcttgg tcaggaaata gtcggtgatc ccgttgaccc gggtggcgta 18300 gcgggctatc acggcgtcga accacccgca acgccgccgt cgtcctgtcg tcacgccgat 18360 ctcgctacca gtcttggcca agtactcgcc gttctcgtcg aacagttcgg tagggaaagg 18420 accagaaccc acccgagtag tgtaggcctt gagaatgcct agcacagtgt ggatccgggt 18480 cggtccgata ccggagccca acgccgcacc gcccgccgtc ggattcgacg atgtcacata 18540 cgggtaggtg ccgtgatcaa cgtcgagcag ggtgccttgt gcgccttcaa gcagcaccgt 18600 ctcaccggcc tcgagggcgt cgttgagcaa cagacgagtg tcggtgatgc gatgtcgaaa 18660 ttgctgcgcc tgctccagca gcgtttcgac aacctgagcc aggtccaacg ccttgcggtt 18720 gtagatcttg accaacacct ggtttttgaa ctcgagcgca gcctcgatct tgtgggtcaa 18780 ctcaccaggt tctaagacat cggcgacccg tatccccatg cgggcgatct tgtcctggta 18840 acagggcccg ataccgcggc cggtagtgcc gatcttcttg ttgcccatgt aacgctcggt 18900 gaccttgtcg atggccacgt ggtagggcat cagcaggtgc gcatcggctg agatcagcag 18960 ctgggaggtg tcgacaccac gatcttccag gccttgcagt tcgctgagca gcactccggg 19020 atccaccacc acaccgttac cgatgacgtt ggtaacaccc ggcgtcagca cccccgacgg 19080 gatcagatgc agtgtgaagt tctcgccagt aggcaagaca acggtatgcc cagcgttatt 19140 gccaccctga tagcgcacca cccactgggc acgtccgccg agcaggtctg tgaccttacc 19200 tttgccctcg tcgccccact gagcgccgat gaggacgact gccggcattg acttgctccc 19260 acctaaatcc cgcgtgttta cgcctgctta ttgtggtcca gccggtgatc aacttagccc 19320 tgcaatgatg cgagccgtgc tcggcccgct gtggggtaac ccccagccgc gtaccggcgg 19380 tagggaggcc gagcagttct agctcgaaca caaccgtttg cgaggagtat cttgaacacg 19440 tccgatagcg cccccggcgt ggcggtgttg ctgtttggcg acgaccgaac ccgacaacga 19500 tggaacaccc taaccgcgct gtccacctac cgggccggcg gtcccgacga catcgactcc 19560 attgacgcga cgatcggccc gtacaggcga ctggtggtcg ttggcggcga cggcgacctg 19620 gcagcggtgc tgggacggct gttacgtgcc gaccggctcg acattgaggt ggcttatgta 19680 ccgcaccaac gcaccgcggc gactcgggtc tatcgccttc cgaccgggcg ccgagcggcg 19740 cgacgcgccc ggcgcggtta cgccacgcgg gtaccgctga tccgcgacga gaccgggtcg 19800 gtgatcgtag gcagggcaga ctggcttccg gttgtcgacc gacagccgtt gcacggtgag 19860 gcaatagttg atgacatccc gctgttcgac ggcgatgtcg ccggcgtgcg catcgcaccg 19920 acgctggcca tgccgggctt acgggccagg ttgcatacct cccgaactgg cataggcatc 19980 tggagccgat ggctcaccgg ccgagcggtg cagctaggca gcaccggtgt cgctgtggta 20040 cgtgatggtg tcccgacgcg ccgtcgggag cggcgatcga cgttctaccg caacgtcgaa 20100 ggctggatgc tggtccggta attgctactg gtaagttctc ccgttcagca caaatcggtg 20160 cgacctcgcc cgaatctttg tggccctggt cagactggac caccgccgag ctgtgctgtc 20220 gtagctcgcc ggggtgagcg tgcgaccact ggcacatgcc ggagtgttta tcttcgtgat 20280 cgcgccgact ggttggtttc gctgtgtctg cacgaatgcg ggcacacgcc taaggcttga 20340 cgattcggca aacaagacgt ctcagcaacc acgatattgc agtgcagcgg ctacctgaca 20400 atggatctgc tgcggttacc gcgatccggc gctctcactt gctggtgacg atgtggttca 20460 tcgtgctggg cagtatcgtc ctgccgggtg cagccgtgga cttgcggacc tggttcatga 20520 agcctacccg tccgcaccct ggtcagcttg gcggaccggc ggccaacctt gcgttggcta 20580 tgctgatgat aatgctgatc aggttgtatt acgaccctgc gcacacagcc ttgtaggcag 20640 aggtggcgta gccggcggtg gccagggctc gcacgtcggg ctccggggcc tggaagatca 20700 cgacgactca aagccgcata ttaagtcccg agatcaaatc tgccaagcag tacgctgtgt 20760 tcattttgct gttctctttg ttggcactag gcatgaacca cgtttctctt cgtggatcgt 20820 gtactggcgc tcttcaactt gcctggtgtg acccactggc tggtgaccgt ggacaatgca 20880 tttgcccact ttaatggagc cgctggttct aacgcttgca atgcatgcgt aaacacgcat 20940 atattgcaca catgggctct gggggtagtt acactcccgc tgaggccgcc atatatcgga 21000 tgatccgccg catgatcgtt gccgcagcga tcttgatggt gttctttggt gtggagctga 21060 ccatagcgtt actgatcaac tcgatcacac tgctcgccga tgcgggacac atgctcaccg 21120 acgtagttgc cgtgttcatg gggctggccg cattggtgct ggctaagcat ggtcactcag 21180 cacccaaccg cccctacagc tggcatcgcg ccgaggtatt taccgcaatg gccaacgccg 21240 cgctgctgat cggggtcgcg acgttcatcc tatacgaggc gatccgacgg ttcaaggaag 21300 ccccgtacat cccgggcatg ccgatagtgg tggcggcgct ggccggcctg gtcaccaatt 21360 tcgtggtagc gctgttgttg cgcccgcacg cggaggacag cctggcaatt aagggtgcct 21420 atatggaggc ggtcgcggac accgtaggca acatcggtgt gctgatcgcc ggtgttgtca 21480 ccctaaccac gcactggccc tacgccgacg tggtggtcgc cgtgctggtg gcgctctggg 21540 tgctgccacg ggcaatctcg ctagcccggg cggcttgcgg atcttttcct aattgtcgcc 21600 ggcccacaat cgatgtcgag gcactgcgtt cagcactagg acgcaggcga cgtcaccgaa 21660 gtgcacgacc tgcacgtgtg aacactttcg ctcggcgaag atatgtccca ccgcgcacct 21720 gaccagcaac agcaactcca tccggaggtg ggccggctct ggaacgggtc cgatgttggc 21780 cgaagtcctg ggaaaggcta gcctacgcga cagtccagat cggatgtacc gacgacatct 21840 atgactgttc ggaaatcttc tagagcccga gctcgttgcg agctgcgggg tcgcaatcgt 21900 caagcagatt caggcagcgt ctatactcgt cggtctcacc aatggcgttc gcggcccgcg 21960 ccagcgcggc cacgcagcgc aggaagccgc ggttcggctc gtgcgaatac ggcaccgggc 22020 caaaaccttt ccagccattg cagcgcagct gatcgagacc gcggtggtag ccagtgcggg 22080 catacgcgta agctgtggta gccttatcgt cggccagtgc cccctcagca agtgccgccc 22140 aggccaccga cgcggaagga tgggcggcgg caacggttcc gggatccttg tttgcgcgca 22200 gttccacctc ggcggcgctg tcatcgggca gcagtatcgg atcaggcccc aggagatcac 22260 ccattgacgt catggtctcc attctgccgt tcaccccgcc agcacatcga ctcacgcctc 22320 aatccgggtc cagagtcgct aaactctaaa tattgactcg atagcgggaa gacaggagcg 22380 ctaaatgcct aatgcatccg agcccgaacg cggcatcaca ctaaaccgcc ccgggttggc 22440 tccacgcact ttggataaga acgtcgtgtc caatctaccc gaagccaaag acaacccggc 22500 catgactcac ggcgaagaga tcgccgcagg ctacccacta gcgcatagcg actcggaaac 22560 cgaggcgatg gtactaacca aaaccgagcc agaccaagat cccggggcag acagacagca 22620 tcacgagcgc cgcttcaccg cacccggctt cgacgccaga gcgaccgcca tcatggccac 22680 tgcaccggat cccgcgaccg aagccatcca ccctccctta agctcgtccg atccaccagg 22740 acatctaggg atttccccaa aagctgctgt accacaatcg attccacccg tgctaggaac 22800 taagttgcgg tcagctcgac attttcattg gggctgggtg gtggcgctgc tcatgatggt 22860 gttggcgtta gcggcgatcg caattctcgg caccgtgctg ctgacccgtg gtaaacacgt 22920 gaaagcctcg ccggcagaac aggttcggca cgccatccag agctttgacg tcgcggtgca 22980 aaccggcaac ctgacggcgt tgcgctctat aacctgcggt accacccgcg acggctacgt 23040 ggagtacgat gagtcctcgt gggacgagac gtaccacaga gtttcagcgg ccaaacaata 23100 tccggtgatc gccagcatcg accaggtcgt cgtgaacggc caacacgccg aagcaaacat 23160 caccacgttc atggcctacg acccacaggt ccgctcgaca cgcagccttg acctgcagtt 23220 ctgcgacgat caatggaaga tctgccagtc ccctagcggc taactcaaca gtcaactgtc 23280 aactagccgc caccgacttt ccggcgcaac gtagatcgtt acaggcctca agcacccgct 23340 cggtcatcga tgcttcggcc ttcttaagat agctgcgcgg gtcgtacacc ttcttattgc 23400 ccacatcgcc gtcgacctta agcacgccgt cgtagttagt gaacatgtga ccggacactg 23460 ggcgagtgaa tgcatattgg gtatcggtgt caacgttcat cttcaccaca ccgtaccgca 23520 gcgcctcctc gatctccgac ttttccgaac cggaaccgcc gtggaacaca aaatcgaacg 23580 gtttcgagcc ctcagactga ctgagcttgg ccgctgccac cttctgacct tcggccagga 23640 tgtcgggacg cagcttaacg ttgccaggct tatagacacc gtgcacgttg ccaaacgtcg 23700 cagccagcag atacttgccg tgttcaccgg cgcccagagc atctatcgtc ttcacgaaat 23760 ccttcggagt agtatataat ttttcgttga tttcgccggc cacgccgtct tcctcgccgc 23820 cgaccacacc gatctcgact tcgagaatga tcttggcggc cgctgcgtcc ttcagcagat 23880 cttgggctat ggccagattc tcatcgatcg gtatcgcaga gccatcccac atgtgcgatc 23940 cgaacagcgg atccttaccg gtcgctaccc ttctagccga gatcgccagc aaagggcgca 24000 cgtaactgtc cagtttgtcc ttgggacagt ggtcagtgtg cagtgcaacg ttgatcgggt 24060 acttggccgc aatagtgtga gtgaacttcg ctagcgctac cgcacccgtc accatgtcct 24120 tcacgccgag cccggaggcg aactccgcac caccggtgga aaactggatg atgccgtcac 24180 tgccagcgtc agcaaagcct ttgatagcgg cgttgacggt ctctgaagac gtacagttga 24240 tggccggaaa agcgtatgag ttttccttgg cgcgtctcaa catctcggcg tagatctccg 24300 gtgttgcgat aggcatgaaa cttccctcct gaaaactgag tctatccagt atcgcaacat 24360 cccaatgccg gttagcagcc aatctgcgca ggattttttg tccacagcca gcagaggcta 24420 cgtgtttcgg tcggtatgtt gtgacgtcat gaacaccgcc atagtggcct tgccgcccac 24480 cctcgacccg atgttctgga ttggtcccga gggctttttc gcggcggcga tgcttcccgc 24540 caccctggtc atcatcttcg tcgaaaccgg cttgctgttc ccattgctac ctggcgaatc 24600 actgctgttc accggggggc tgttggccac taaggggacg atcgatatct gggtgttgtc 24660 cccttccgta gcggtggtag cggtattagg cgatcagatc gggtatctca tcggtcggcg 24720 catcggcccc gcactgttca agaaagaaaa ttcacgcttc ttcaagcagc actacgtaac 24780 cgagtcgcac gccttcttcg agaagcacgg gcgatggacg atcatcctag cccgtttctt 24840 gccgttcatg cggacgttca ccccggtgat cgcgggctta tcctatatga gttatccatt 24900 gtatctgggg ttcgacatcg tgggcggcat cctctggggc ggaggcgtca cggttgccgg 24960 ctacttcctg ggcaacgtgc cgttcgtccg ccagaattta gagaaaatca tcctgggcat 25020 tctattcgtg tcactgctgc cagcgctgat tgcggcctgg cacggctatc ggtcgcagag 25080 ccgaacagcc aaaagcgaac tcgccttacc agactgaacc caagcagcta gtggtgggtg 25140 gttttgaggc gtttaggtgt ggttggttga ggtaagtggg cggtgtatgt ggttgctgtc 25200 ttggagttgc gcgatggcga ccggggtcgg ctggggtggt tgacgagggt gttgtgggtg 25260 ctggtggggc aggtgacacg ggcgtggatt gtgtggttgg tgtccgatgg agtggctaga 25320 tactgatatc gcggttcggg tacgccgggg acgggacgtg cttcggtgat cgatgaggtc 25380 atggtgctcg tagagacgtt ggtcggcgat gttatgcgaa tcggccgttc agcgtcggag 25440 cggcccgtca ccggagcagt tgatggctgt gggggatttc gttttccttg gccgcgcgga 25500 tctggcataa gtgggggcat ccagtcgcat cgcgtgaaga ccttcaagtt cgttaccgac 25560 cccgacgtgg gagaccaaac ggcgtgatgt ggtcgggctc gacctggatc cacgtgcgtc 25620 acgaagtgct gatgattggc atggcagtga aggtgagaga tcttcgccgc cgggcctgtc 25680 gcagcaggaa cggtgaagcg ggggcacctt ggccttgggt ggcgtcggga aggggaggaa 25740 tcgtcctagg tcctgcttgg gtgttgtgtg gccaacacga tttatcgggt tggggtcatc 25800 gtcggtcgat cgtggccgca ggtttgatga cctgttcaat ctcgtgtgtg acccggcgaa 25860 cattgttggt ggcgtttgac tgggtcacgg gcaactatgg ggcgaatact gctggtgtgg 25920 acgcccggac cggagcccat gttgaggaaa tcgtcgaggt agcgggttgt tggacaatct 25980 gcggatcgag tcgttcaggc tgcgttgaag ctggtgttgg agcctgtcgt cgaggccgct 26040 ttcgagccga tctcccctgg attccgcccc caagcggcga tctcagggac acgatcgccg 26100 aaattcacca atacagcact acaagctatc ggtgggtgct gtatgcagac attgaggtgc 26160 gctgtgactc tatctcacat tctgctctgt tggagcggat gctattgcca gtcaaggata 26220 aacgcgtact tggtcctggt gaaggcgttt tctaaggccg gtgtgctcac cgagtctggt 26280 gagcaccaga acactcacac cggaacgtct cagggcaata tcttgtcgcc ggtgctgacc 26340 aacatcgcct tgcctgggct cgatgagtat cggatgcagc catggaaacc gtgcggctcg 26400 atgtccactg cttacctgcc tagtcggcgc cgcgtcacag gcctgctgag tacaacgcag 26460 tcgtcccgcg tagcggacga ctgcgttgta ctcagcacat ggcgaccaga cacgccagag 26520 gcctgcaaaa cgaaataaac tcgatgctta cgcctctagg tctgcagctg tcgactgcaa 26580 agacaaagac cgcgcacttc ggtaactggt atggactttc gcggcttcca caccgggtgg 26640 acacccaaga aggcaacgac cacgtgggca tgtctaggac ttgtatcgcc gaccgggcac 26700 gacggtcggt caaagccaag atccgtgccc tggcaaacag gaaatcacag cgcaatccgg 26760 gggccgtgct ggcacagatc aaccatcggt ggtttcgagc actgtatcgc cggagatgga 26820 aagacattcg ccggcagttc accacctccg aaaaacggtg aaaaccgatt gacgcagaag 26880 agaccaccct attgaacccg acctcgatac cggtcacccg gtaccgctac caaatcacca 26940 caatacccaa cccttggacc agtattccca ccgcctaacg gtagtgacca tgaaaagccc 27000 ggtgcgcaaa gacgcgcaca ccaggatcgg cgaccagtct gggaaacgga ccgaaagtaa 27060 tacacccaca ccgcgcccca ggcctactca acccgcggcc gcgattatgc tctagcgtcg 27120 acaatgaagc cccagaccca agcagctgga tcacacccaa accgattctg ccactacctt 27180 caaactcgcc accaaaacac acccacacat acaggcatgc cccaatctgc gacaactacg 27240 ccaacccaca aacccccagc agccgatcct ggctacagga taaccagcaa gccacactgc 27300 acttcacacc gacaagctgc tcatagctga cacataacca aaatcttctt caccaccatc 27360 acccgccaca acacgttcac cgatatcaac aacctcgaaa ccgcgatccc cacctacaac 27420 gaacacacca caccgttcac ctgaacccag accgcagaca ccccctcaac aaaatcaaac 27480 gttaaaacaa tcaccaacac acaacactag cgaacacatc agacctgact taactcatgt 27540 ttggcgacat tgactagctg caacggtttg acctgatggt ttgtggttgg gatcggttgc 27600 aagaaagcac cccgtgtcac catcgttgaa actgctatgg gatgaaatga attcggagtg 27660 aaccaaatcg ggaccgcatt aacacgaaga taacatcgcc accacgtgcc ttatctaatc 27720 acacagaacg tggctgttct caacttttat catcagtatc tgtaattatt ttacgcatca 27780 ctggcgtcca cataacactg ggctgagaaa atgttaataa aggcttctct tgggtagtag 27840 ggatactaaa taatatcgtt aatttggtgt agagataagc aatctaaata tattttagat 27900 aatgctattt gattgtttat ggatttcgta ccgggcttcg ataatttctg ctagattatt 27960 ctaggatgtt atcgacggtg atcgttaagc ggattgattg gactcgatcg attaggtagt 28020 gttgcttggg tggctaagct acgtctggtg tatctacccc cgaatccagc atcacgtacg 28080 ttgtatttga ccggggagat cgcttagtgc gatctgtggt tttcgtcggt tgaaatgtcg 28140 gtgttgcccg ggcaaaaacc aagccgatgc ggttacggat tttatctgca tgcgagaggt 28200 ttttggtctc cgttgtccga tgtgccggaa gtgacctcat catcgagttt gtcgagaagg 28260 gcaggaacga acggagaggg ttggtacgta tggcaacctc agcaagccag cgaacctcgc 28320 caacgaacga gagctggtca ggttggtgaa aaacctcatt agggtcggtg gccaccgagc 28380 tactgctatg agcgttcact ggggagacga ttcgtgccac ttccaccgac ccagctgtgg 28440 gacgcttgct aatttatgat gtgccgtgtg acggcgagtt gttcggctcg tgtggttgtt 28500 tccggacgca agtgtggttg aagaatcaaa caaggcgtca caattttcta taacgctacg 28560 gtacagacaa gtccgaatag attgctgcat cgttgtagtt attcatatcg tgtaggtgag 28620 cgtgttgccc aaatctgacc acaaaggacg ccgtcggtag agtgtccaca ttagctgcac 28680 tgctccgtta gttcgcaggg tccttgaaag gcacagtaag ccgatcagca tttcgccgca 28740 tcgaggctaa cggaagttgg ggcgaccgcg atgttcaacg attacatgga gattcccgca 28800 taggtggcgg tgatggccat tgccttgccg atgctgtata cgatcgtaac tctagaccct 28860 agaaccggca ggaacaggac gctgcgcaat tagatttggg cgtgcacaag cacttatcta 28920 gtgggtgcac agcacaatca agcatagaag cctgaagata tacgtgcaga gatcaatctt 28980 ccaagaagat gtcagaggta ccactcatcg catagtgcta tagtggtatt ttaaatagat 29040 tgggtcactt tggtcatgca ctggtgatgc gaaaaaagaa ggattgctat ggcagtgact 29100 acaatgaggc tcaccgccat cgtccggcga aggcgagaga ccgaagtttc cggtgcagcg 29160 tgacatgcgg tttgtgctgt aggcggtaca cacgatgtcg accagtgcgg cggtgaggat 29220 ggccgagtct atcaggctag cgagactggg gatactgctc acgcgccccg atccactggt 29280 agaatatgga gcactgcacc ttcgaagcct attgctgaac aaactatggc tactgtaacc 29340 gcccaccgtt ccgaactgtg agggtttctg attgctagat tcagtcgcca gatcaacgtc 29400 acgctagcga gtgcaccagc actgctgtgt acgttatcgc gaactgcacc tcgggtcagg 29460 ccccggtgac tagagtcgca aaaagaattc tgatttcagt ctcgattgtc gtcatccatt 29520 cctgatgatg accgtatgta gcgtgttgaa aataagcatt ttactatgcg atcggcttag 29580 tgttcttcgt cgctttatga tcagctacgg tccaggatac ttcgcacgag ggatgggatc 29640 gatactcgac gcgagcagat gtagtgcata attttcggat acgacctggt ggttgccagc 29700 aagcacattg ccaaattcgt ggtaggcaat gtggtactga tgcaccttgc tagtcaggag 29760 gtggtaaact atgatatcga tatcggaagc aattagtatg gcctcgagaa ttcttctacc 29820 ggaagctgtt ccgtacgcag gcacatcggc ctactccact gctgtgtcaa cgtcttggct 29880 agctgagtca ctgtgaacct attcgccaag ttagctcggt tagtttgtca gttgcgcagc 29940 ttttcacaga cggttagtca acaaaagtat aaccgtagtc ttggcgacgt cttcggctaa 30000 gcctcggtac gtaacctcga ctgtttgacc gtcgcgtacc atcggcgtgt gcatcgagtt 30060 gattgagtct agttgagtac caacgtaacc gaatgctgtt actttctctg tatttcggat 30120 tcacgtctcc caagttacat tcgagattgg tttttactaa attgcagttc gctgagtctg 30180 cgcttttcaa ataccggcga tgatgttaag ctcggttccc tggtagggta agcgtcctgc 30240 ggtagtgaaa tccgtaacac cagataattg tatccccgcg gtcgattacg caaatacccg 30300 gccagcgcat atagagctgg ttgagcacgg ccgccgctgc ggtatggggt gcgggtcggg 30360 ttggttcgag ctcgtcggta cagttaaatc tttgtggatc atggttagcc gatgcaagat 30420 ataaccgtac cgtctgtcca gcgacgactg tatgctgacc gatctcaaca tcggtgactg 30480 cgaagcgcgg tccagccaac cctggtggtg agagaaagca caatagtgcg tcgaccgctg 30540 aggtctggtc ggagccgaag taaagagttt tagagttgct catgcctact cgacaacgtc 30600 agcaccgacc cagtcagcaa gtctatgagc actttaagta ccaaacaaag agcagttaga 30660 acagcagcct ggccagttcg ttggctttaa cactactggc tgcgatcaac cgggtgagca 30720 gagtctgggt cgctacccct agtggctgtc aagtccaata atttactgca tgctagctaa 30780 cgtgtctcat gctcgcggca gccctggccg ggtgcatcgt tgaattcgcc cgtgctagtg 30840 atcgatcgcg agcgtcatca ggcagtccaa gcagctcgcc gagtatgaca gccagtagca 30900 gaatagcgat gcggtcaacg aagtagaact cgcagacctc ctggagttga cacattatta 30960 agatcaatca actgcgaagc ctgagcagtc gattcgtccc gtcgtcgcag agccagcttg 31020 gctaccagcc gtcgccgcag acatacgata tcatcggcat cactagttgg aaaaatatcc 31080 agcggggttg gcatggctaa actccgataa tcgaaccggt ctgtgaaccg catcccggtg 31140 tcagcggtta ggtttccgac aacggcgacg aaagcttccg tgcgaactcc tggtcaaaga 31200 tgtcgagtgc gctactagcg cacacacatc acatgtacag cctataccgt ccttgcagca 31260 acgtggaaac ctggctagcg taacatgagg taccggctgg aatccattgc gactgtcaag 31320 ggacttgaac ttaactggat cctatgctaa ataagcatgt tgccgaaatt gaagtgctgg 31380 gcatcagttg gcgttcatga gtagctactg ccatagtgat tatgacttga aatcgtttgc 31440 gctcaagttg ttctagccgt gtctgccatc agttcgttcg agagcttcac gcttgacgag 31500 cttgtcgata atgtcgctga cggttcctga actcgtctgg cgatggttcg ccgcatacaa 31560 agcgatattg ctaaccccca tattgcacac tgctccaagc agttccagtt ctgtttggat 31620 ctgcttactc gggtcgtcat caaagaagta ggcaaccggc acatcgaaaa atcagccaat 31680 gtctgcaatg acgcttcatc ggattgtctt cgcctggtcg tacacaacct gccataggtt 31740 atgtaggcga gaagctgtct cccgcaacct cctagcacac cgccgaaacc tcatttatta 31800 gtatgctatt cctcattcgg tgcacggacg atttggaaaa acttatcgat cttgtgggca 31860 agcgtcacgg gaggcttcga gccgccggca gtcatggggc acctaaactt cccaatcgat 31920 ggataagatc gacgggctgg gtttccaccg cacaaaatcc acatggcaat ctcctcctga 31980 gcctgatggg cagctggtag ctcatgaaat cgtcacgtca taacctttag ctcttccgag 32040 atccctgcct ttactggcaa caatctctcc tacacgagac ctgccgagcg catacccttc 32100 tgcacgccgg tagcaactca tgttaaagcg acagcagtca atccatgcta gttggcaaag 32160 cgggcgatgc aggccgtatt aggtaatgcc gttggtgtgg tgaacaacgg tgacaacatc 32220 gaccggcctg aataaaagct tagacacgac ttttcagatt ggagtcgaca atactcgaca 32280 acaccataac gcgccacgtc acagaagatg tatcgggctt cgcggctatc gcggagggca 32340 tcgtacacac cgtttagcat gaattacgac acatttgacc gctgggtaga catcgaaggt 32400 aatgagttgg ggtgcaaact tcacgatctt agtgacgact gtgctggatc ggtcttgtcg 32460 cacttagttt catagggcgc tcagtgctgt tgtgctcgtc ggctatcttg acatcgaact 32520 caacgtccac gcaggaggca ctggatatct tgtgcggctc aagcaatgcc gctggctgct 32580 agcagttggt gttaatcctc aacggaagac acgcattgtg cttgccagca tattgtctta 32640 tctttcagcg aagagaaaat acttaattcc ttaatttttg caaaaattat gcgatgttcg 32700 tcaatttgct attaaacgac ctagctgata gcccgctatg taaagcgggt agctttcatg 32760 tatagacttg ggccagtgtt gctatgtgct aattggtgac caattgtacg gttctgtgat 32820 gtcagtccag agccgtgcct cttaacgaag aaggctcaca acaagatacg atcgtggccg 32880 gatgtataaa acgatatcac actacgtagg ttaaagtact gaacctagct tcgatatagt 32940 cattcgaacg cgatctatgt ggggagtgat ggcgctcaat caacgtagtg agggagcgtc 33000 acgtcaaggg tctcgtgccg cgtctctagc cgggtgtcgt caatcgtgta agtgaggtcg 33060 attagtagtt cgcggtgccc aataccgtgc tagattcaat ccaatgtttg gtcggccact 33120 acgatcgtgt tgtgcacacc gctcgaagtg tctacgaaac tgtgacgact cgaaaacaac 33180 tcctcagagt gcaatgcatg atcgagcaaa tcctcgatgt gtacacgatc ggccgaatac 33240 ttttgcttgc tagaccaaca gttttgttgt agacaacacc gctcaatcga cagctgccat 33300 agcgatggct aatcctggtc tgtacctgcc gcgcatacta accactggaa cactgcgcta 33360 gaatttcgaa tggaggggaa caacaaaaaa ccacgcggga gcacacacca agtgcgctga 33420 gaggacggat cggggccgtc gaccgtatga acctgaccgg gtaatgccgg cgtagggaga 33480 tgaataatga ctgaaacctt gtcgaaaacc actgaaccat ccgtaaccac cggaccgatc 33540 cctggaagca gcaaggctta ccgagaagta gcgaacccgg atggcggacc tagcctgcgg 33600 gtaccgttcc gccgagtaca tctatccacc ggcgcccatt tcgaccttta cgacacttcc 33660 gggccctaca ccgatcccga tgcggtgatc aacctgacgg ccgggttgcc gcccaggccc 33720 ggcgtgatcc gtgaccgtgg cacacaactg cagcgggccc gtgccggaga gattactgcg 33780 gagatggcgt tcatcgctga ccgcgagggc atgcccgccg agttggtgcg cgtcgaggtc 33840 gcccttggcc gcgcggtgat tcctgccaac |