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EBI DbfetchID AL583917; SV 1; linear; genomic DNA; STD; PRO; 344050 BP. XX AC AL583917; XX DT 20-FEB-2001 (Rel. 66, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 3) XX DE Mycobacterium leprae strain TN complete genome; segment 1/10 XX KW . XX OS Mycobacterium leprae OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium. XX RN [1] RP 1-344050 RX DOI; 10.1038/35059006 RX PUBMED; 11234002. RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., RA Wheeler P.R., Honore N., Ganier T., Churcher C., Harris D., Mungall K., RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., RA Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., RA Jagels K., Lacroix C., Maclean J., Moule S., Murphy L., Oliver, Quail M.A., RA Rajandream M-A., Rutherford K.M., Rutter S., Seeger K., Simon S., RA Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., RA Whitehead S., Woodward J.R., Barrell B.G.; RT "Massive gene decay in the leprosy bacillus"; RL Nature 409(6823):1007-1011(2001). XX RN [2] RP 1-344050 RA Parkhill J.; RT ; RL Submitted (20-FEB-2001) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Mycobacterium leprae sequencing teams, The RL Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, RL UK Unitie de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du RL Docteur Rouux, 75724, Paris Cedex, France. E-mail: parkhill@sanger.ac.uk XX DR EMBL-CON; AL450380. DR RFAM; RF00005; tRNA. XX CC Notes: CC CC Details of M. leprae sequencing at the Sanger Centre CC are available from http://www.sanger.ac.uk/Projects/M_leprae/ CC A relational datbase containing the M. leprae sequences is available from CC http://genolist.pasteur.fr/Leproma/ XX FH Key Location/Qualifiers FH FT source 1..344050 FT /organism="Mycobacterium leprae" FT /strain="TN" FT /mol_type="genomic DNA" FT /db_xref="taxon:1769" FT CDS 1..1566 FT /transl_table=11 FT /gene="dnaA" FT /gene_synonym="ML0001" FT /product="putative chromosomal replication initiator FT protein" FT /note="Similar to M. tuberculosis dnaA, chromosomal FT replication initiator protein, SW:DNAA_MYCTU (P49993) (507 FT aa); Fasta score E(): 0, 87.2% identity in 507 aa overlap FT and Mycobacterium smegmatis dnaA, SW:DNAA_MYCSM (P49992) FT (495 aa); Fasta score E(): 0, 69.2% identity in 441 aa FT overlap. Previously sequenced as SW:DNAA_MYCLE (P46388) FT (521 aa); Fasta score E(): 0, 99.8% identity in 521 aa FT overlap. Contains Pfam match to entry PF00308 bac_dnaA, FT Bacterial dnaA protein. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop). Contains PS01008 DnaA protein FT signature." FT /db_xref="GOA:P46388" FT /db_xref="HSSP:1L8Q" FT /db_xref="InterPro:IPR001957" FT /db_xref="UniProtKB/Swiss-Prot:P46388" FT /protein_id="CAC29509.1" FT /translation="MFVPHAKKPEIYENQRDTSLADDLSLGFTTVWNAVVSELNGESNT FT DDEATNDSTLVTPLTPQQRAWLNLVQPLTIIEGFALLSVPSSFVQNEIERHLRTPITDA FT LSRRLGQQIQLGVRIAPPSTDHIDDNSSSADVLLTDDCGTDTDENYGEPLTGEYQGLPT FT YFTERPHHTESTVTGGTSLNRRYTFETFVIGASNRFAHAAALAIAEAPARAYNPLFIWG FT ESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDV FT LLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGL FT ITDVQPPELETRIAILRKKAQMERLAVPGDVLELIASSIERNIRELEGALIRVTAFASL FT NKTAIDKALAEIVLRDLIADASTMQISAATIMTATAEYFDTTIEELRGPGKTRALAQSR FT QIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQ FT RSKR" FT misc_feature 544..1482 FT /note="Pfam match to entry PF00308 bac_dnaA, Bacterial dnaA FT protein, score 712.20, E-value 8.3e-240" FT misc_feature 664..687 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 1426..1482 FT /note="PS01008 DnaA protein signature" FT CDS 2081..3280 FT /transl_table=11 FT /gene="dnaN" FT /gene_synonym="ML0002" FT /product="putative DNA polymerase III, [beta] subunit" FT /EC_number="2.7.7.7" FT /note="Similar to M. tuberculosis dnaN, DNA polymerase III, FT [beta] subunit, SW:DP3B_MYCTU (Q50790) (402 aa); Fasta FT score E(): 0, 80.9% identity in 403 aa overlap and FT Mycobacterium smegmatis dnaN, SW:DP3B_MYCSM (P52851) (397 FT aa); Fasta score E(): 0, 77.3% identity in 397 aa overlap. FT Previously sequenced as SW:DP3B_MYCLE (P46387) (399 aa); FT Fasta score E(): 0, 100.0% identity in 399 aa overlap. FT Contains Pfam match to entry PF00712 DNA_pol3_beta, DNA FT polymerase III beta subunit." FT /db_xref="GOA:P46387" FT /db_xref="InterPro:IPR001001" FT /db_xref="UniProtKB/Swiss-Prot:P46387" FT /protein_id="CAC29510.1" FT /translation="MDLAKTNVGCSDLKFCLARESFASAVSWVAKYLPTRPTVPVLSGV FT LLTGSDSGLTISGFDYEVSAEVQVAAEIASSGSVLVSGRLLSDITRALPNKPVHFYVDG FT NRVALTCGSARFSLPTMAVEDYPTLPTLPDETGTLPSDVFAEAIGQVAIAAGRDYTLPM FT LTGIRIEISGDTVVLAATDRFRLAVRELKWSVLSSDFEASVLVPAKTLVEVAKAGTDGS FT GVCLSLGAGVGVGKDGLFGISGGGKRSTTRLLDAEFPKFRQLLPAEHTAVATIDVAELT FT EAIKLVALVADRGAQVRMEFGDGILRLSAGADDVGRAEEDLAVAFTGEPLTIAFNPNYL FT TDGLASVHSERVSFGFTTPSKPALLRPTSNDDVHPTHDGPFPALPTDYVYLLMPVRLPG FT " FT misc_feature 2117..3214 FT /note="Pfam match to entry PF00712 DNA_pol3_beta, DNA FT polymerase III beta subunit, score 592.70, E-value FT 2.2e-174" FT CDS 3281..4438 FT /transl_table=11 FT /gene="recF" FT /gene_synonym="ML0003" FT /product="putative DNA replication and SOS induction FT protein" FT /note="Similar to M. tuberculosis recF, DNA replication and FT SOS induction protein, SW:RECF_MYCTU (Q59586) (385 aa); FT Fasta score E(): 0, 76.4% identity in 385 aa overlap and FT Mycobacterium smegmatis recF, SW:RECF_MYCSM (P50916) (384 FT aa); Fasta score E(): 0, 70.0% identity in 383 aa overlap. FT Previously sequenced as SW:RECF_MYCLE (P46391) (385 aa); FT Fasta score E(): 0, 99.5% identity in 385 aa overlap. FT Contains 2 Pfam matches to entry PF00470 RecF, RecF FT protein. Contains PS00617 RecF protein signature 1. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT Contains PS00618 RecF protein signature 2." FT /db_xref="GOA:P46391" FT /db_xref="InterPro:IPR003395" FT /db_xref="UniProtKB/Swiss-Prot:P46391" FT /protein_id="CAC29511.1" FT /translation="MYVRHFGLRDFRSWDHVDLELNPGRTVFFGPNGNGKTNLIEALWY FT STTLSSHRVGTDIPLIRAGTIRAIVSTIVVNEGRECAIDLEIAAGRANRARLNRSLVRG FT MREVVGVLRAVLFAPEDLALVCGDPANRRRYLDDLATVRQPVIAAVRADYDKVLRQRTA FT LLKSLAAARYRSDQGVLDTLDVWDTRLAEHGAELMAARIDLVNQLAPEVEKAYQLLAPG FT SRTASISYRASLDIGGIAGVGSSDRALLQADLLAGLSTRRNVELERGICLVGPHRDELE FT LRLGDQPAKGFASHGESWSLAIALRLAAYELLRADGNEPVLLLDDVFAELDAARCRALA FT TVAESAEQVLVTSAAQEDIPVGWDAKWVTVDLRDSDSGRVSVVYP" FT misc_feature 3287..3415 FT /note="Pfam match to entry PF00470 RecF, RecF protein, FT score 18.90, E-value 0.00024" FT misc_feature 3368..3391 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 3614..3691 FT /note="PS00617 RecF protein signature 1" FT misc_feature 4100..4423 FT /note="Pfam match to entry PF00470 RecF, RecF protein, FT score 5.20, E-value 1.5" FT misc_feature 4244..4297 FT /note="PS00618 RecF protein signature 2" FT CDS 4435..5004 FT /transl_table=11 FT /gene="ML0004" FT /product="conserved hypothetical protein" FT /note="Similar to hypothetical proteins from mycobacteria FT e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 FT (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% FT identity in 167 aa overlap. Previously sequenced as FT TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% FT identity in 187 aa overlap." FT /db_xref="InterPro:IPR007922" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDF4" FT /protein_id="CAC29512.1" FT /translation="MIESNESYSYGGDTIEPLGTLSGFDLVRRALEEARAAACAQGKDA FT GRGHVVPPVPFRVTDRRRNWSGPGPDVRDPQPLGKVAHDLAKKRGWSAQVAEGRVFGQW FT ASMVGGQIADHAFPVGLNNGVLSVTAESTAWATQLRIMQAQLLAKIAAAVGNGVVTSLK FT ITGPTAPSWRKGPWHIAGRGPRDTYG" FT RBS 5211..5216 FT /note="possible RBS" FT CDS 5229..7265 FT /transl_table=11 FT /gene="gyrB" FT /gene_synonym="ML0005" FT /product="putative DNA gyrase subunit B" FT /EC_number="5.99.1.3" FT /note="Similar to M. tuberculosis gyrB, DNA gyrase subunit FT B, SW:GYRB_MYCTU (P41514) (686 aa); Fasta score E(): 0, FT 87.5% identity in 679 aa overlap and to Mycobacterium FT smegmatis gyrB, SW:GYRB_MYCSM (P48355) (675 aa); Fasta FT score E(): 0, 85.0% identity in 679 aa overlap. Previously FT sequenced as SW:GYRB_MYCLE (Q59533) (697 aa); Fasta score FT E(): 0, 100.0% identity in 678 aa overlap. Contains Pfam FT match to entry PF00986 DNA_gyraseB_C, DNA gyrase B subunit, FT carboxyl terminus. Contains Pfam match to entry PF00204 FT DNA_topoisoII, DNA topoisomerase II (N-terminal region). FT Contains PS00177 DNA topoisomerase II signature." FT /db_xref="GOA:Q59533" FT /db_xref="HSSP:1AJ6" FT /db_xref="InterPro:IPR006171" FT /db_xref="UniProtKB/Swiss-Prot:Q59533" FT /protein_id="CAC29513.1" FT /translation="MAAQRKAQDEYGAASITILEGLEAVRKRPGMYVGSTGERGLHHLI FT WEVVDNSVDEAMAGYATQVDVRLFDDGSVEVADNGRGIPVAVHATGVPTVDVVMTQLHA FT GGKFGGKDSGYNVSGGLHGVGVSVVNALSTRVEVDIKRDGYEWSQFYDKAVPGILKQGE FT ATEATGTTIRFWADPDIFETTKYDFGTVARRIQEVAFLNKGLTINLVDERVKQDEVVDD FT VVSDTAEAPVAMTVEEKSTESSAPHKVRHRTFHYPGGLVDFVKHINRTKTPIQQSIIDF FT DGKGAGHEVEVAMQWNGGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDKKL FT LKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQRVCNEQLIHWF FT EANPVDAKAVVNKAISSAQARIAARKARELVRRKSATDLGGLPGKLADCRSTDPRSSEL FT YVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIH FT DEFDISRLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIEHGYVFLAQPPLYKLKW FT QRMDPEFAYSDSERDGLLETGLKLGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRV FT LRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV" FT misc_feature 5274..7001 FT /note="Pfam match to entry PF00204 DNA_topoisoII, DNA FT topoisomerase II (N-terminal region), score 1031.00, FT E-value 0" FT misc_feature 6606..6632 FT /note="PS00177 DNA topoisomerase II signature" FT misc_feature 7029..7229 FT /note="Pfam match to entry PF00986 DNA_gyraseB_C, DNA FT gyrase B subunit, carboxyl terminus, score 154.30, E-value FT 2.1e-42" FT CDS 7318..11067 FT /transl_table=11 FT /gene="gyrA" FT /gene_synonym="ML0006" FT /product="putative DNA gyrase subunit A" FT /EC_number="5.99.1.3" FT /note="Similar to M. tuberculosis gyrA, DNA gyrase subunit FT A, SW:GYRA_MYCTU (Q07702) (838 aa); Fasta score E(): 0, FT 91.1% identity in 695 aa overlap and to Mycobacterium FT smegmatis gyrA, SW:GYRA_MYCSM (P48354) (842 aa); Fasta FT score E(): 0, 88.2% identity in 692 aa overlap. Previously FT sequenced as SW:GYRA_MYCLE (Q57532) (1273 aa); Fasta score FT E(): 0, 99.9% identity in 1246 aa overlap. Contains a FT probable intein from aa 131 to 550 inclusive. Contains 2 FT Pfam matches to entry PF00521 DNA_topoisoIV, DNA FT gyrase/topoisomerase IV, subunit A. Contains PS00018 FT EF-hand calcium-binding domain. Contains PS00881 Protein FT splicing signature." FT /db_xref="GOA:Q57532" FT /db_xref="HSSP:1AM2" FT /db_xref="InterPro:IPR013757" FT /db_xref="UniProtKB/Swiss-Prot:Q57532" FT /protein_id="CAC29514.1" FT /translation="MTDITLPPGDGSIQRVEPVDIQQEMQRSYIDYAMSVIVGRALPEV FT RDGLKPVHRRVLYAMLDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPW FT SLRYPLVDGQGNFGSPGNDPPAAMRYCVSGNSLVRLLFGKSIRIGDIVTGAQFNSDNPI FT DLKVLDRHGNPVVADYLFHSGEHQTYTVRTTEGYEITGTSNHPLLCLVNVGGIPTLLWK FT LIGEIRSGDYVVLQRIPPVEFGPADWYSTMEALLFGAFISGGFVFQDHAGFNSLDRDYF FT TMVVNAYDTVVGGLRCISSRITVSGSTLLELDVYNLIEFKKTRLSGLCGQRSADKLVPD FT WLWHSPSTVKRAFLQALFEGEGFSSILSRNIIEISYSTLSERLAADVQQMLLEFGVVSE FT RYCHTVNEYKVVIANRAQVEMFFTQVGFGVTKQAKLIRDVVSMSPCVGMDINCVPGLAT FT FIRKHCDNRWVEEDSFNQHNVDCVQHWHHHSAEIVGHIADPDIRAIVTDLTDGRFYYAR FT VASVTDTGIQPVFSLHVDTEDHSFLTNGFISHNTEARLTPLAMEMLREIDEETVDFISN FT YDGRVQEPMVLPSRFPNLLANGSGGIAVGMATNIPPHNLYELADAVFWCLENHDADEET FT MLVAVMERVKGPDFPTAGLIVGSQGIADAYKTGRGSIRIRGVVEVEEDSRGRTSLVITE FT LPYQVNHDNFITSIAEQVRTGRLAGISNVEDQGSDRVGVRIVIEIKRDAVAKVVLNNLY FT KHTQLQTSFGANMLSIVDGVPRTLRLDQMICYYVEHQLDVIVRRTTYRLRKANERAHIL FT RGLVKALDALDEVITLIRASQTVDIARVGVVELLDIDDIQAQAILDMQLRRLAALERQR FT IIDDLAKIEVEIADLGDILAKPERRRGIIRNELTEIAEKYGDDRRTRIIAVDGDVNDED FT LIAREEVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVRHFFVCSTHDWIL FT FFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLAT FT RAGLVKKSKLTDFDSNRSGGIVAINLRDNDELVGAVLCAADGDLLLVSANGQSIRFSAT FT DEALRPMGRATSGVQGMRFNADDRLLSLNVVREDTYLLVATSGGYAKRTSIEEYPMQGR FT GGKGVLTVMYDRRRGSLVGAIVVDEDSELYAITSGGGVIRTTARQVRQAGRQTKGVRLM FT NLGEGDTLLAIARNAEESADGGVG" FT misc_feature 7435..7707 FT /note="Pfam match to entry PF00521 DNA_topoisoIV, DNA FT gyrase/topoisomerase IV, subunit A, score 239.20, E-value FT 6e-75" FT misc_feature 8947..8970 FT /note="PS00881 Protein splicing signature" FT misc_feature 8968..10053 FT /note="Pfam match to entry PF00521 DNA_topoisoIV, DNA FT gyrase/topoisomerase IV, subunit A, score 669.60, E-value FT 7.4e-211" FT misc_feature 10090..10128 FT /note="PS00018 EF-hand calcium-binding domain" FT RBS 11184..11189 FT /note="possible RBS" FT repeat_region complement(11189..11473) FT /note="285 bp repeat, shares 98% sequence identity 280/285 FT with bases 3145214..3145498" FT CDS 11195..12106 FT /transl_table=11 FT /gene="ML0007" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv0007, hypothetical FT protein, TR:P71575 (EMBL:AL123456) (304 aa); Fasta score FT E(): 0, 53.8% identity in 316 aa overlap. Previously FT sequenced as TR:O32870 (EMBL:Z70722) (303 aa); Fasta score FT E(): 0, 99.7% identity in 303 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /note="Contains a region identical to ML2630" FT /db_xref="GOA:O32870" FT /db_xref="UniProtKB/Swiss-Prot:O32870" FT /protein_id="CAC29515.1" FT /translation="MTSPNESRAFNAADDLIGDGSVERAGLHRATSVPGESSEGLQRGH FT SPEPNDSPPWQRGSARASQSGYRPSDPLTTTRQSNPAPGANVRSNRFISGMTAPALSGQ FT LPKKNNSTQALEPVLMSNEVPFTESYASELPDLSGPVQRTVPCKPSPDRGSSTPRMGRL FT EITKVRGTGEIRSQISRRSHGPVRASMQIRRIDPWSMLKVSLLLSVALFFVWMIAVAFL FT YLLLGGMGVWAKLNSNVGDLLNNTGGNSGELVSNSTIFGCAVLVGLVNIVLMTTMAAIA FT AFVYNLSSDLVGGVEVTLADLD" FT tRNA 12194..12270 FT /gene="ileT" FT /note="tRNA Ile anticodon GAT, Cove score 88.84" FT tRNA 12404..12479 FT /gene="alaT" FT /note="tRNA Ala anticodon TGC, Cove score 86.68" FT CDS complement(12856..13230) FT /transl_table=11 FT /gene="ML0008" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CDF1" FT /protein_id="CAC29516.1" FT /translation="MATIRTVRNLKLCNPISDHSTRLLTVVVKQRSKAFRPSVLIRTWA FT NQLEVNSAALAYNAGHQSSKAEGVNTDIARLQAQTDEEVYSRPISDNTEYGVGLSRSAI FT CSRVSYGSECRSGNCLRYTK" FT RBS 13763..13766 FT /note="possible RBS" FT CDS 13775..13966 FT /transl_table=11 FT /gene="ML0009" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CDF0" FT /protein_id="CAC29517.1" FT /translation="MRLCVFTGTVDAGGDHYMLVVMLVIIVTSAVTTAICDLLGSFYYP FT LKHVFATKCGRFVIIYLS" FT CDS complement(15426..15767) FT /pseudo FT /transl_table=11 FT /gene="ML0010" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0008c (Best blastx score 124)" FT CDS 15993..16541 FT /transl_table=11 FT /gene="ppiA" FT /gene_synonym="ML0011" FT /product="putative peptidyl-prolyl cis-trans isomerase" FT /EC_number="5.2.1.8" FT /note="Similar to M. tuberculosis ppiA, peptidyl-prolyl FT cis-trans isomerase, SW:CYPA_MYCTU (P71578) (182 aa); Fasta FT score E(): 0, 90.1% identity in 182 aa overlap and FT Streptomyces chrysomallus ScCypB, peptidyl-prolyl cis-trans FT isomerase B, TR:P77949 (EMBL:U64692) (175 aa); Fasta score FT E(): 0, 63.3% identity in 166 aa overlap. Contains Pfam FT match to entry PF00160 pro_isomerase, Cyclophilin type FT peptidyl-prolyl cis-trans isomerase." FT /note="Similar to ML0492" FT /db_xref="GOA:Q9CDE9" FT /db_xref="HSSP:1H0P" FT /db_xref="InterPro:IPR002130" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDE9" FT /protein_id="CAC29519.1" FT /translation="MAHCDFVTNSLIQNATATLHTNRGDIKVALFGNHVPKTVANFVGL FT AQGTKEYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFHPE FT LQFDKPYLLAMANAGPGTNGSQFFITVGETPHLNRRHTIFGEVTDPDSQKVVDAISTTA FT TDGNDRPTEPVVIDSITIS" FT misc_feature 16062..16529 FT /note="Pfam match to entry PF00160 pro_isomerase, FT Cyclophilin type peptidyl-prolyl cis-trans isomerase, score FT 193.30, E-value 2.8e-55" FT CDS complement(16566..16979) FT /transl_table=11 FT /gene="ML0012" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv0010c, hypothetical FT protein, SW:Y010_MYCTU (P71580) (141 aa); Fasta score E(): FT 0, 71.5% identity in 137 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CDE8" FT /protein_id="CAC29520.1" FT /translation="MQQTAWGPRTARIAGCGGAGIVIAIACSTLDIDTPGFMLTGIAAL FT GLILFAGLSWRARPKLAINPDGLAVQGWFRTRLFGPADIKIIRITEFRRFGRKVRLLEI FT EAINGDLVILSRWDLGTGPLEVLDALITAGYAG" FT CDS complement(17134..17415) FT /transl_table=11 FT /gene="ML0013" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0011c, hypothetical FT protein, SW:Y011_MYCTU (P71581) (93 aa); Fasta score E(): FT 0, 89.2% identity in 93 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions." FT /db_xref="GOA:Q9CDE7" FT /db_xref="InterPro:IPR009619" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDE7" FT /protein_id="CAC29521.1" FT /translation="MPKSKVRKKNDFTITSVSRTPVKVKVGPSSVWFVTLFVGLMLIGL FT VWLMVFQLAALGTQAPTALHWMAQLGPWNYAIAFAFMITGLLLTMRWH" FT RBS complement(17421..17424) FT /note="possible RBS" FT CDS 17483..18283 FT /pseudo FT /transl_table=11 FT /gene="ML0014" FT /product="possible cell division protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0012 (Best blastx score 411)" FT CDS 18325..19023 FT /transl_table=11 FT /gene="pabA" FT /gene_synonym="ML0015" FT /product="putative p-aminobenzoate synthase glutamine FT amidotransferase" FT /note="EC_number=4.1.3.-" FT /note="Similar to M. tuberculosis pabA, p-aminobenzoate FT synthase glutamine amidotransferase, TR:Q50183 FT (EMBL:Z70722) (232 aa); Fasta score E(): 0, 100.0% identity FT in 232 aa overlap (EMBL:AL123456) (232 aa); Fasta score FT E(): 0, 100.0% identity in 232 aa overlap and to FT Azospirillum brasilense trpG, anthranilate synthase FT component II, SW:TRPG_AZOBR (P26922) (196 aa); Fasta score FT E(): 0, 56.1% identity in 187 aa overlap. Previously FT sequenced as TR:Q50183. Contains Pfam match to entry FT PF00117 GATase, Glutamine amidotransferase class-I. FT Contains PS00442 Glutamine amidotransferases class-I active FT site." FT /db_xref="GOA:Q50183" FT /db_xref="HSSP:1QDL" FT /db_xref="InterPro:IPR017926" FT /db_xref="UniProtKB/TrEMBL:Q50183" FT /protein_id="CAC29523.1" FT /translation="MRILVIDNYDSFVFNLVQYLGQLGVDAEVWRNDDTRLSDESTIAA FT QFDGILLSPGPGTPERAGASINLVRVCAAAHTPLLGVCLGHQAIGVSFGATVDRAPELL FT HGKTSSVFHTNNGVLQGLPNPFTATRYHSLTILPESLPPVLEVVARTRSGVIMAVRHTE FT LPIHGVQFHPESILTEGGHRLLANWLTYCGWLCDDALIRRLENEVDAAVHPRLPVAAER FT TAAAIARTLA" FT misc_feature 18334..18900 FT /note="Pfam match to entry PF00117 GATase, Glutamine FT amidotransferase class-I, score 264.50, E-value 1.4e-75" FT misc_feature 18556..18591 FT /note="PS00442 Glutamine amidotransferases class-I active FT site" FT CDS complement(19001..20869) FT /transl_table=11 FT /gene="pknB" FT /gene_synonym="ML0016" FT /product="putative serine/threonine protein kinase" FT /note="EC_number=2.7.1.-" FT /note="Similar to M. tuberculosis pknB, serine/threonine FT protein kinase, SW:PKNB_MYCTU (P71584) (626 aa); Fasta FT score E(): 0, 86.3% identity in 626 aa overlap and to FT Streptomyces coelicolor pksC, serine/threonine protein FT kinase, TR:Q9ZFS8 (EMBL:AF094711) (556 aa); Fasta score FT E(): 0, 47.8% identity in 297 aa overlap. Previously FT sequenced as SW:PKNB_MYCLE (P54744) (622 aa); Fasta score FT E(): 0, 99.7% identity in 622 aa overlap. Contains Pfam FT match to entry PF00069 pkinase, Eukaryotic protein kinase FT domain. Contains PS00108 Serine/Threonine protein kinases FT active-site signature. Contains PS00107 Protein kinases FT ATP-binding region signature." FT /note="Similar to ML0017 and ML0897 and to part of ML0304" FT /db_xref="GOA:P54744" FT /db_xref="HSSP:1MRU" FT /db_xref="InterPro:IPR002290" FT /db_xref="UniProtKB/Swiss-Prot:P54744" FT /protein_id="CAC29524.1" FT /translation="MTTPPHLSDRYELGDILGFGGMSEVHLARDIRLHRDVAVKVLRAD FT LARDPSFYLRFRREAQNAAALNHPSIVAVYDTGEAETSAGPLPYIVMEYVDGATLRDIV FT HTDGPMPPQQAIEIVADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAI FT ADSTSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGEPPFIGDSPVS FT VAYQHVREDPIPPSQRHEGISVDLDAVVLKALAKNPENRYQTAAEMRADLIRVHSGQPP FT EAPKVLTDADRSCLLSSGAGNFGVPRTDALSRQSLDETESDGSIGRWVAVVAVLAVLTI FT AIVAAFNTFGGNTRDVQVPDVRGQVSADAISALQNRGFKTRTLQKPDSTIPPDHVISTE FT PGANASVGAGDEITINVSTGPEQREVPDVSSLNYTDAVKKLTSSGFKSFKQANSPSTPE FT LLGKVIGTNPSANQTSAITNVITIIVGSGPETKQIPDVTGQIVEIAQKNLNVYGFTKFS FT QASVDSPRPTGEVIGTNPPKDATVPVDSVIELQVSKGNQFVMPDLSGMFWADAEPRLRA FT LGWTGVLDKGPDVDAGGSQHNRVAYQNPPAGAGVNRDGIITLKFGQ" FT misc_feature complement(20054..20839) FT /note="Pfam match to entry PF00069 pkinase, Eukaryotic FT protein kinase domain, score 191.50, E-value 1.4e-53" FT misc_feature complement(20432..20470) FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT misc_feature complement(20750..20821) FT /note="PS00107 Protein kinases ATP-binding region FT signature" FT CDS complement(20879..22192) FT /transl_table=11 FT /gene="pknA" FT /gene_synonym="ML0017" FT /product="putative serine/threonine protein kinase" FT /note="EC_number=2.7.1.-" FT /note="Similar to M. tuberculosis pknA, serine/threonine FT protein kinase, SW:PKNA_MYCTU (P71585) (431 aa); Fasta FT score E(): 0, 81.0% identity in 431 aa overlap and to FT Streptomyces coelicolor pksC, serine/threonine protein FT kinase, TR:Q9ZFS8 (EMBL:AF094711) (556 aa); Fasta score FT E(): 2.1e-29, 39.9% identity in 346 aa overlap. Previously FT sequenced as SW:PKNA_MYCLE (P54743) (437 aa); Fasta score FT E(): 0, 84.6% identity in 448 aa overlap. Contains Pfam FT match to entry PF00069 pkinase, Eukaryotic protein kinase FT domain. Contains PS00108 Serine/Threonine protein kinases FT active-site signature." FT /note="Similar to ML0016 and ML0897 and to part of ML0304" FT /db_xref="GOA:P54743" FT /db_xref="HSSP:1O6Y" FT /db_xref="InterPro:IPR000719" FT /db_xref="UniProtKB/Swiss-Prot:P54743" FT /protein_id="CAC29525.1" FT /translation="MSPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKVLK FT GEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHMDGEGRTAYLVMELVNGEPLN FT SVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIA FT KAVDAAPVTQTGMVMGTAQYIAPEQALGHDATPASDVYSLGVIGYEVVSGKRPFTGDGA FT LTVAMKHIKEPPPPLPADLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPP FT RPNQTPSSGRASPTTIPSSTQARAAVACGTKTPAPRRSRPSTSGNRPPPARNTFSSGQR FT ALLWAAGMLGALAIIIAVLIVINSYAGNEQHQPPTPTVTDTGTPPATKTLSGFPAAYCE FT YRVNWTNHKEISNSGLPKQAARAQLAGATDISPVAGQT" FT misc_feature complement(21410..22156) FT /note="Pfam match to entry PF00069 pkinase, Eukaryotic FT protein kinase domain, score 187.90, E-value 1.6e-52" FT misc_feature complement(21746..21784) FT /note="PS00108 Serine/Threonine protein kinases active-site FT signature" FT CDS complement(22189..23667) FT /transl_table=11 FT /gene="pbpA" FT /gene_synonym="ML0018" FT /product="putative penicillin-binding protein" FT /note="Similar to M. tuberculosis pbpA, penicillin-binding FT protein, TR:P71586 (EMBL:AL123456) (491 aa); Fasta score FT E(): 0, 85.7% identity in 490 aa overlap. Also similar to FT Bacillus subtilis penicillin-binding protein 3, pbpC, FT SW:PBPC_BACSU (P42971) (668 aa); Fasta score E(): 2.8e-15, FT 24.5% identity in 444 aa overlap. Previously sequenced as FT TR:Q50185 (EMBL:Z70722) (474 aa); Fasta score E(): 0, 96.4% FT identity in 472 aa overlap. Contains a probable N-terminal FT signal sequence. Contains Pfam match to entry PF00905 FT Transpeptidase, Penicillin binding protein transpeptidase FT domain." FT /note="Similar to region of ML1577" FT /db_xref="GOA:Q9CDE6" FT /db_xref="InterPro:IPR001460" FT /db_xref="UniProtKB/TrEMBL:Q9CDE6" FT /protein_id="CAC29526.1" FT /translation="MNTSLRRISVTVMALIVLLLLNATVTQVFTADGLRADPRNQRVLL FT DEYSRQRGQITASGQLLAYSVATDNRFRFLRVYPNPAVYAPITGFYSLRYSSTGLEQAE FT DALLNGSDERLFGRRLADFFTGRDPRGGNVDTTINPRVQQTGWDAMQQGCGGSPCKGAV FT VALEPSTGKILAMVSTPSYDPNLLASHNPEEQAQAWRRLHDDPNSPLINRAISETYPPG FT STFKVITTTAALQAGATTSDQLTAEPTIPLPGSTATLENYGGVSCGPGPTVSLSQAFAM FT SCNTAFVQLGLLIGADALRSMAHSFGLDSNPNVIPLQVAESTVGVIPDAAALGMSSIGQ FT RDVALTPLQNAQIAATIANAGVTMQPYLIDNLKGPDLANIRTTTSYQQHRAVSPQIAAT FT LTELMVGAEKVTQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPVQAPKVAVA FT VLVEKGADSLFATGGALAAPIGRAVIEAALQGGA" FT misc_feature complement(22222..23250) FT /note="Pfam match to entry PF00905 Transpeptidase, FT Penicillin binding protein transpeptidase domain, score FT 351.70, E-value 8.2e-102" FT CDS complement(23664..25061) FT /transl_table=11 FT /gene="rodA" FT /gene_synonym="ML0019" FT /product="putative cell-division protein" FT /note="Similar to M. tuberculosis ftsW, cell-division FT protein, SW:FTSW_MYCTU (P71587) (469 aa); Fasta score E(): FT 0, 82.3% identity in 469 aa overlap and to Streptomyces FT coelicolor ftsW, cell-division protein, TR:Q9ZBA6 FT (EMBL:AL109663) (456 aa); Fasta score E(): 3.3e-25, 32.1% FT identity in 377 aa overlap. Previously sequenced as FT SW:FTSW_MYCLE (Q50186) (465 aa); Fasta score E(): 0, 99.6% FT identity in 465 aa overlap. Contains hydrophobic, possible FT membrane-spanning regions. Contains Pfam match to entry FT PF01098 FTSW_RODA_SPOVE, Cell cycle protein. Contains FT PS00428 Cell cycle proteins ftsW / rodA / spoVE signature." FT /note="Similar to ML0913" FT /db_xref="GOA:Q50186" FT /db_xref="InterPro:IPR018365" FT /db_xref="UniProtKB/Swiss-Prot:Q50186" FT /protein_id="CAC29527.1" FT /translation="MTTQLQPVVTVTPPLPTRRNAELLLLGFAAVITVAALAIVEANQE FT RNFRWYLAGYGLIFWSLFASAHLAIRRFAPYTDPLLLPIVALLNGLGLVMIHRLDLVDN FT DVTGHHHTSAAQQMLWTLVGVAAFVLVMTVLKDHRQLARYGYISGLTGLVFLAIPAPLP FT EQNGAKIWIRFPGFSIQPAEFSKILLLIFFAAVLVAKRSLFTSAGKHLIGMTLPRPRDL FT APLLAAWVISVSVMVFEKDLGTSLLLYASFLVVVYLATQRLSWVIIGLVLFTAGSTIAY FT FTFEHIRVRMQVWWDPFTNLDVGGYQIVQSLFSFATGGIFGTGLGNGQPDAIPAASTDF FT IIAVFGEELGLVGLAALLMLYTIVIVRGLRTAIATRDSFGKLLAAGLASTLAIQLFIVS FT GGVTTLIPLTGLTTPWMSYGGSSLLANYVLLAILARISHSARHPLRSRPHNTSPIAVAS FT TEVIERV" FT misc_feature complement(23736..24830) FT /note="Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell FT cycle protein, score 563.80, E-value 1.1e-165" FT misc_feature complement(23796..23870) FT /note="PS00428 Cell cycle proteins ftsW / rodA / spoVE FT signature" FT CDS complement(25058..26587) FT /transl_table=11 FT /gene="ML0020" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis ppp, putative protein FT phosphatase, TR:P71588 (EMBL:AL123456) (514 aa); Fasta FT score E(): 0, 76.4% identity in 513 aa overlap and to FT Streptomyces coelicolor SCH69.15, possible protein FT phosphatase, TR:Q9XA19 (EMBL:AL079308) (515 aa); Fasta FT score E(): 0, 40.2% identity in 532 aa overlap. Also FT similar to many other proteins of undefined function. FT Previously sequenced as TR:Q50188 (EMBL:Z70722) (509 aa); FT Fasta score E(): 0, 99.6% identity in 509 aa overlap. FT Contains hydrophobic, possible membrane-spanning region. FT Proline-rich C-terminus." FT /db_xref="GOA:Q9CDE5" FT /db_xref="InterPro:IPR014045" FT /db_xref="UniProtKB/TrEMBL:Q9CDE5" FT /protein_id="CAC29528.1" FT /translation="MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEV FT ASQLVIAALAHLDDDEPGGDLLGKLETAVRAGNLAIAAQVEMEPDFEGMGTTLTAILFA FT GNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITAEEAHSHPQRSLIMRAL FT TGHEVDPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPDVAESAYRLIELALRG FT GGPDNVTVVVADVIDYDYGQTQPILAGAVSGEESQQMALPNTAASRASAIVPRKEIAKS FT MAPQVDKVHQQRWSQRQTGITLTLLVLLVLAGVAIGRWVIRDNYYIAEYSGKVSIVRGI FT QGSLLGMPLHEPYLVGCLNTRNELSLISYGQSGGHLNCQVMTLRDLRPSGGAQVQAGLP FT GGNLDQAESQLRKLLADSLLPTCPPPRATSPPGPFTMPTDSGTPQPTNTASPTSTTPPT FT ITSSSGTAPTNISPTSSPASTAPTTPVGTSQTVTILPPPPPQPGIDCRAVA" FT CDS complement(26584..27051) FT /transl_table=11 FT /gene="ML0021" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0019c, hypothetical FT protein, TR:P71589 and to Streptomyces coelicolor SCH69.14, FT hypothetical protein, TR:Q9XA20 (EMBL:AL079308) (172 aa); FT Fasta score E(): 2e-21, 44.4% identity in 171 aa overlap. FT Previously sequenced as TR:Q50189 (EMBL:Z70722) (155 aa); FT Fasta score E(): 0, 100.0% identity in 155 aa overlap. FT Contains Pfam match to entry PF00498 FHA, FHA domain." FT /note="Similar at the C-terminus to ML2076" FT /db_xref="HSSP:1MZK" FT /db_xref="InterPro:IPR000253" FT /db_xref="UniProtKB/TrEMBL:Q50189" FT /protein_id="CAC29529.1" FT /translation="MQGLVLQLARAGFLMLLWVFIWSVLQILKTDIYAPTGAVMVRRSL FT TLRNTLLLSRQRRHAARYLMVTEGSLTGARITLSGQPVLIGRADDSTLVLTDDYASNRH FT ARLSQRGSEWYVEDLGSTNGTYLDRAKVTTAVRVPLGTPVRIGKTAIELRP" FT misc_feature complement(26611..26805) FT /note="Pfam match to entry PF00498 FHA, FHA domain, score FT 74.50, E-value 2.2e-18" FT RBS complement(27058..27063) FT /note="possible RBS" FT CDS complement(27173..28639) FT /transl_table=11 FT /gene="ML0022" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0020c, hypothetical FT protein, TR:P71590 (EMBL:AL123456) (527 aa); Fasta score FT E(): 0, 71.9% identity in 531 aa overlap. Previously FT sequenced as TR:Q50190 (EMBL:Z70722) (463 aa); Fasta score FT E(): 0, 100.0% identity in 463 aa overlap. Contains Pfam FT match to entry PF00498 FHA, FHA domain." FT /note="Similar at the C-terminus to ML2076" FT /db_xref="HSSP:1MZK" FT /db_xref="InterPro:IPR000253" FT /db_xref="UniProtKB/TrEMBL:Q9CDE4" FT /protein_id="CAC29530.1" FT /translation="MDNQKELIQRIERKLESSIDDAFARMFGGSIVPQEVEALLRREAS FT DGVRSLQGNRLLAPNEYIITLGVHDLEKMKADPDLTSSAFASDLADYIHEQGWQTYGDV FT VVRFDQSSSLHTGQIRARSVVNPDVEPRPTVNDPVRTQSNQAFSAEPGVPPMTDNSSYR FT GGQGQGRPSDDYYGRPQDDPRGADPQGGQDPRGCYPPKPGSYPQQAGHPPLHRPDQGGY FT PGQGGYEDQRAYHDQGQGGYPSPYEQRPATPGGYGSQGHDQGYRPGSYGPPSGGQPGYG FT GYGDYGRGPARPDEGSYTPSGFPAPPEQRVAYPDQGGGYDQGYQHSGLGYGREDYGRQE FT YTQYAENLPGGVYAPSSGGYAEPAGRDYDYGQPGAANDYSQPVIGGYGGYGALGSAVIL FT QLDDGSGRTYQLREGSNIVGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGT FT TVNNAPVQEWQLADGDVIRLGHSEIIVRIH" FT misc_feature complement(27203..27394) FT /note="Pfam match to entry PF00498 FHA, FHA domain, score FT 89.70, E-value 5.9e-23" FT tRNA 28890..28972 FT /gene="leuT" FT /note="tRNA Leu anticodon CAG, Cove score 63.58" FT CDS complement(28954..29265) FT /transl_table=11 FT /gene="ML0023" FT /product="hypothetical protein" FT /note="Improbable CDS, possibly the remains of a disrupted FT gene." FT /db_xref="UniProtKB/TrEMBL:Q9CDE3" FT /protein_id="CAC29531.1" FT /translation="MPTQPHFRIQHDTVNQFSKRTLCHGSLLHHLGIGRTHTHTPVLMP FT VTTNIVTIISKTGHHLIASQCINFDHNYWPNQTKFPGRWPGNFVTHDSTHHESGRRGT" FT CDS 29775..30026 FT /transl_table=11 FT /gene="ML0024" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CDE2" FT /protein_id="CAC29532.1" FT /translation="MPFDYHVAAEPQYFAGQHVVLTAVHDHDGVDSLADAFDDKPELGN FT TLQHIGSSRAAIRGAGDDCGRFRKKFLEATGYVNTKSS" FT CDS complement(30293..30583) FT /transl_table=11 FT /gene="ML0025" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CDE1" FT /protein_id="CAC29533.1" FT /translation="MTDTTGTADASGPDNLDESESGSGDEAGAGRTTLDCARPSDNRYR FT RELRELAFLRYVGIRTEKEFAERSICFLCELSCRLTGRAQLATPTRCGWIV" FT CDS complement(31015..31651) FT /pseudo FT /transl_table=11 FT /gene="PPE" FT /gene_synonym="ML0026" FT /product="PPE-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT PPE (Best blastx score 99)" FT CDS complement(32113..32920) FT /pseudo FT /transl_table=11 FT /gene="ML0027" FT /product="probable membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0037c (Best blastx score 178)" FT CDS 33100..33705 FT /transl_table=11 FT /gene="ML0028" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0038, hypothetical FT protein, TR:P71608 (EMBL:AL123456) (202 aa); Fasta score FT E(): 0, 88.1% identity in 202 aa overlap. Similar to FT Streptomyces coelicolor SCE59.07C, hypothetical protein, FT TR:CAB72194 (EMBL:AL138851) (193 aa); Fasta score E(): FT 3.5e-28, 45.6% identity in 182 aa overlap and shows weak FT similarity to many other bacterial hypothetical proteins. FT Previously sequenced as TR:Q50191 (EMBL:Z70722) (202 aa); FT Fasta score E(): 0, 100.0% identity in 201 aa overlap." FT /db_xref="InterPro:IPR003774" FT /db_xref="UniProtKB/Swiss-Prot:Q50191" FT /protein_id="CAC29536.1" FT /translation="MIRPEDPEDYVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIVEH FT NEGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKTMFIGGPVKRDAALCLAVLRIGADPD FT GVAGLRHVAGRLVMVDLDAEPDLIAPLVDGLRIFVGYSGWTIGQLKGEIERDDWIVLSA FT LPSDVLVGKRADLWAQVLRRQPLLLSLLATHPIDVSRN" FT CDS complement(34033..34638) FT /transl_table=11 FT /gene="ML0029" FT /product="possible membrane protein" FT /note="Contains a region similar to part of several FT bacterial hypothetical membrane proteins e.g. Streptomyces FT coelicolor SC4B5.06, putative transmembrane protein, FT TR:Q9ZBW2 (EMBL:AL034443) (345 aa); Fasta score E(): FT 2.4e-14, 54.1% identity in 109 aa overlap. The coding frame FT predicted by GC frameplot changes to either side of this FT region of similarity, suggesting that an ancestral CDS was FT disrupted. Given this, ML0029 may not be functional. FT Contains hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CDE0" FT /protein_id="CAC29537.1" FT /translation="MRQPAPCLSSRKRPSSYFILLRHPSVAAAELAQWPPVLAGLVGAD FT ATFVVFLALGLAIQFLMSSVLTIDLYNEVLFLFLVPSTVRSSIAFTSIARGHVSASIMN FT ASLSNILGVVVTPLLVVLLMNTSGVPRLDGASIRYVVLQLLLPFEACQLMRPGSLRPLF FT TMSPCSRWSTATPSCWWCTRLSRWAWLKESGSASIRSG" FT CDS complement(34750..35091) FT /transl_table=11 FT /gene="ML0030" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv0039c, hypothetical FT protein, TR:P71696 (EMBL:AL123456) (115 aa); Fasta score FT E(): 2.2e-25, 63.2% identity in 114 aa overlap. Previously FT sequenced as TR:O32871 (EMBL:Z70722) (113 aa); Fasta score FT E(): 0, 100.0% identity in 113 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="GOA:O32871" FT /db_xref="UniProtKB/Swiss-Prot:O32871" FT /protein_id="CAC29538.1" FT /translation="MLIAGTLCVCAAVISAVFGTWALIHNQTVDPTQLAMRAMAPPQLA FT AAIMLAAGGVVALVAVAHTALIVVAVCVTGAVGTLAAGSWQSARYTLRRRATATSCGKN FT CAGCILSCR" FT CDS complement(35287..36123) FT /transl_table=11 FT /gene="ML0031" FT /note="Similar to M. tuberculosis MTC28, Rv0040c, proline FT rich 28 KDa antigen precursoR, SW:PR28_MYCTU (P71697) (311 FT aa); Fasta score E(): 0, 65.1% identity in 258 aa overlap. FT Previously sequenced as TR:O33075 (EMBL:Y14967) (278 aa); FT Fasta score E(): 0, 100.0% identity in 278 aa overlap. FT Contains a probable N-terminal signal sequence." FT /note="C-terminal half is similar to a region of ML0246" FT /db_xref="InterPro:IPR019674" FT /db_xref="UniProtKB/Swiss-Prot:O33075" FT /protein_id="CAC29539.1" FT /translation="MIQSTQTWRVLAGGLAATAMGVTVFAGGTAAADPSPPAPPPAIPG FT VLPPASLPPIQSVTAVPGGITTNNRFVATPQAPGPAALGQPPLAVAAPVSESLHDYFKA FT KNIKLVAQKPHGFKALDITLPVPTRWTQVPDPNVPDAFAVIADRLGNSLYTSNAQLVVY FT NLVGNFDPKEAITHGFVDTQQLSAWQTTNASKADFDGFPSSIIEGTYRENGMTLNTSRR FT HVIASSGPDKYLVSLSVTTALSQAVADAPATNAIVNGFRVSSPTVSAPVPPQLGTR" FT RBS complement(36133..36137) FT /note="possible RBS" FT CDS 36321..39239 FT /transl_table=11 FT /gene="leuS" FT /gene_synonym="ML0032" FT /product="leucyl-tRNA synthase" FT /EC_number="6.1.1.4" FT /note="Similar to M. tuberculosis leuS, leucyl-tRNA FT synthetase, SW:SYL_MYCTU (P71698) (969 aa); Fasta score FT E(): 0, 83.6% identity in 972 aa overlap and to Bacillus FT subtilis leuS, leucyl-tRNA synthetase, SW:SYL_BACSU FT (P36430) (804 aa); Fasta score E(): 0, 45.7% identity in FT 941 aa overlap. Previously sequenced as SW:SYL_MYCLE FT (Q50192) (972 aa); Fasta score E(): 0, 99.9% identity in FT 972 aa overlap. Contains Pfam match to entry PF00133 FT tRNA-synt_1, tRNA synthetases class I (I, L, M and V). FT Contains PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature." FT /db_xref="GOA:Q50192" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:Q50192" FT /protein_id="CAC29540.1" FT /translation="MTELPTTVPGYNSAVAQTDSDAMRYRYTAELAGRIESTWQDNWAR FT LQTFNVPNPVGSLAPPDGSVVPADKLFVQDMFPYPSGDGLHVGHPLGYIATDVYARYFR FT MTGHNVLHAMGFDAFGLPAEQYAMQTGTHPRILTEANVVNFRHQLGRLGLGHDSRRTFS FT TTDVEFYKWTQWIFLQIYNAWFDVAANKARPIAELIAEFDSGERRLVDGRDWATLSAGE FT RADVIDNCRLVYRADSMVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRIT FT AYADRLLDDLDLLDWPEQVKTMQRNWIGRSSGATVLFSAILSRSDAATTEVDVEVFTTR FT PDTMFGVTYLVLAPEHNLVDELVATVWPDRTDPRWTYGAATPGAAVAAYRRAIVAKSDL FT DRQESKEKTGVFLGRYATNPATGKPVPIFVADYVLVGYGTGAVMAVPGHDPRDWDFAHK FT FHLPIVEVIAGSDISEAAYVGDGVLVNSGYLDGMDVATAQEAITARLESEGRGHARIEF FT KLRDWLFARQRYWGEPFPIIYDSDGRPHALDEAALPVELPDVPYYSPVLFDPDDADSEP FT SPPLAKATEWVHVELDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNSERLCAKENE FT AYWMGPRPTEHGIDDPGGVDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSREPYRRLI FT NQGYIQAFAYTDAHGSYVPANQVFQRGDGFFCPGPDGEIEVFQEFGKIGKSLKNSVSPD FT EICDEYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVVDERTGETRVVDT FT AGELDTYTLRTLHRTIAGVSQDYAALRNNTATAKLIEYTNHLTKEHRGSVPRVAVEPLV FT LMLAPLAPHLAEELWLRLGHTTSLANGPFPQADPAYLVDDTVEYPVQVNGKIRGRIVVA FT ADADYDTLKTVALADDKVQQFLAGATPRKVIVVAGRLISLVI" FT misc_feature 36480..38816 FT /note="Pfam match to entry PF00133 tRNA-synt_1, tRNA FT synthetases class I (I, L, M and V), score 241.00, E-value FT 1.7e-68" FT misc_feature 36558..36590 FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT repeat_region 39269..39991 FT /note="Dispersed repeat, RLEP, copy 1" FT CDS 39947..40211 FT /pseudo FT /transl_table=11 FT /gene="ML0033" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv3906c (Best blastx score 95)" FT CDS 40825..41032 FT /pseudo FT /transl_table=11 FT /gene="ML0034" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3890c (Best blastx score 54)" FT CDS 42222..43083 FT /pseudo FT /transl_table=11 FT /gene="ML0035" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3888c (Best blastx score 182)" FT CDS 43199..43699 FT /pseudo FT /transl_table=11 FT /gene="ML0036" FT /product="probable membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3887c (Best blastx score 186)" FT CDS 44077..45332 FT /pseudo FT /transl_table=11 FT /gene="ML0037" FT /product="protease (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3886c (Best blastx score 160)" FT CDS 45397..46827 FT /pseudo FT /transl_table=11 FT /gene="ML0038" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3885c (Best blastx score 128)" FT stem_loop complement(45886..45945) FT /note="60 bp palindrome" FT CDS 47271..48642 FT /pseudo FT /transl_table=11 FT /gene="ML0039" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3884c (Best blastx score 288)" FT repeat_region 49168..50496 FT /note="1329 bp repeat. 100% identical to region FT 3042159..3043487" FT CDS complement(49689..49946) FT /pseudo FT /transl_table=11 FT /gene="ML0040" FT /product="putative transposase remnant" FT /note="Possible transposase remnant, similar to the FT N-terminus of M.tuberculosis Rv2424c, probable transposase FT for IS1558, TR:P71924" FT RBS 50644..50647 FT /note="possible RBS" FT CDS 50656..51996 FT /transl_table=11 FT /gene="ML0041" FT /product="probable secreted protease" FT /note="Similar to M. tuberculosis putative proteases e.g. FT Rv3883c, probable secreted protease, TR:O05461 FT (EMBL:AL123456) (446 aa); Fasta score E(): 0, 79.1% FT identity in 446 aa overlap. Shows weaker similarity to FT known bacterial proteases e.g. Bacteroides nodosus aprV5, FT acidic protease V5, TR:Q46541 (EMBL:L18984) (595 aa); Fasta FT score E(): 1.8e-07, 28.1% identity in 442 aa overlap. FT Previously sequenced as TR:O33076 (EMBL:Y14967) (446 aa); FT Fasta score E(): 0, 99.8% identity in 446 aa overlap. FT Contains a probable N-terminal signal sequence. Contains 2 FT Pfam matches to entry PF00082 Peptidase_S8, Subtilase FT family." FT /note="Similar to ML1538 and ML2528" FT /db_xref="GOA:O33076" FT /db_xref="HSSP:1DBI" FT /db_xref="InterPro:IPR015500" FT /db_xref="UniProtKB/TrEMBL:O33076" FT /protein_id="CAC29549.1" FT /translation="MHRILLMMVALALLYAPPALAINPPSIDPGAVPPDVTGPDQPTEQ FT KVMCSAPTTLPDSSFHDPPWSNIYIGVSEAHKFATGAGVTVAVIDTGVEASPRVPAEPG FT GDFVDQAGNGLSDCDAHGTLTASIIGGRPAPTDGFIGVAPDVRLLSLRQTSEAFQPVGV FT QPNANDPNAIPAAGSIRSLARAVVHAANLGASVINISETACYKANKPLDESTLGAAINY FT AVNVKGVVIIVAAGNTGGDCTQNPMPDVSMPNDPRGWSKVQTIATPAWYAPLVLTVGGI FT AQNGMPSQFSVHGPWVSVAAPTENITTLGYNGEPVNALPGEEGPVALAGTSFATAYVSG FT LAALLRQRFPDLTPAQIINRIIATARHPGGGVDDIVGAGVIDAVAALTWDITPGSASEL FT FNVRSVPPPVITPGPDRNTIMIVAQGILGLSIALGLGVLVRRALQRQ" FT misc_feature 50860..51102 FT /note="Pfam match to entry PF00082 Peptidase_S8, Subtilase FT family, score 13.30, E-value 0.011" FT misc_feature 51184..51819 FT /note="Pfam match to entry PF00082 Peptidase_S8, Subtilase FT family, score 56.80, E-value 8.5e-15" FT CDS 51993..53396 FT /transl_table=11 FT /gene="ML0042" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3882c, conserved FT hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); FT Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows FT weak similarity to M.tuberculosis Rv3885c, hypothetical FT protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score FT E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously FT sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score FT E(): 0, 100.0% identity in 467 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions near the FT N-terminus." FT /note="Shows weak similarity to ML1537" FT /db_xref="UniProtKB/TrEMBL:O33077" FT /protein_id="CAC29550.1" FT /translation="MRNPVWLRFSMGRALLVTALVPPCIILFFHTQYWWAGIALVVLVV FT ILTLVEFSGRWLSGWLMALYSFFRRSSKPLDTPSEPVIGATVKPADQVIMRWQDGFLVS FT VVELIPRPFTPTVIVDGEAQTDDLLETQLLEHLLSVHCPDLEAVVVSAGYRVGHVASLD FT VVNLYQQVIGADPAPAHRRTWIMLRADPVRTRKSAQRRDAGVAGLARYLIASTTRIADQ FT LASHGVDAVCGHSFESVDHATDVGFMQEKWSMMRGQNAYSVAYTAPAGPDAWWSARADH FT TITRVWVAPGKTPQATVVLTTLGKPKTPCGFYRLHGAQQPALLGRSFVAYQHCQMPIGS FT AGVLVGETVNRCSVYMPFDDVDVSVSLGDVQTFTQFVVRAAAAGGIVTLGQQFEKFARM FT IGGQIGSVAKVAWPNATTYLDPYPGSERVILKHDIIGTPRHRKLPIRRISPPEEGHYQM FT VLPKSSYEL" FT CDS 53719..54695 FT /pseudo FT /transl_table=11 FT /gene="ML0043" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3881c (Best blastx score 163)" FT RBS 54684..54689 FT /note="possible RBS" FT CDS 54698..55039 FT /transl_table=11 FT /gene="ML0044" FT /note="Similar to M. tuberculosis Rv3880c, hypothetical FT protein, TR:O69744 (EMBL:AL123456) (115 aa); Fasta score FT E(): 2.6e-21, 56.4% identity in 110 aa overlap. Previously FT sequenced as TR:O33080 (EMBL:Y14967) (113 aa); Fasta score FT E(): 0, 100.0% identity in 113 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O33080" FT /protein_id="CAC29552.1" FT /translation="MDLDPTQAQTMALLGQFQSALDEQCNRMTDGVFKASDQEKTVEVT FT INGYQWLTGIRIESGALREFGHAVVADRINEALQNAQGVATAYNEVSGEQLAARLSALS FT CSIGEPPPT" FT CDS 55581..56699 FT /pseudo FT /transl_table=11 FT /gene="ML0045" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3879c (Best blastx score 189)" FT CDS complement(57567..57922) FT /pseudo FT /transl_table=11 FT /gene="ML0046" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3878 (Best blastx score 118" FT CDS complement(58020..59558) FT /transl_table=11 FT /gene="ML0047" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis putative membrane protein FT e.g. Rv3877, hypothetical protein, TR:O69741 FT (EMBL:AL123456) (511 aa); Fasta score E(): 0, 74.0% FT identity in 512 aa overlap. Similarity is weaker to Rv1795, FT probable membrane protein, TR:O53944 (EMBL:AL123456) (503 FT aa); Fasta score E(): 2.1e-13, 22.7% identity in 519 aa FT overlap and Rv0290, hydrophobic protein, TR:O86362 FT (EMBL:AL123456) (472 aa); Fasta score E(): 2.4e-11, 26.6% FT identity in 512 aa overlap. Previously sequenced as FT TR:O33081 (EMBL:Y14967) (480 aa); Fasta score E(): 0, FT 100.0% identity in 480 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions." FT /note="Similar to ML1539 and ML2529" FT /db_xref="InterPro:IPR006707" FT /db_xref="UniProtKB/TrEMBL:Q9CDD9" FT /protein_id="CAC29555.1" FT /translation="MSAPAVTAGPATAGITPARPSATRVTILTGKRMTDLVLPSTVSIE FT AYIDETVAVLSDLLEDAPADVLAGFDFSAQGVWTFARPGSPPMKLDQSLDDAGVVDGSL FT LTLVSTSRTERYRPLVEDVIDAIAVLNESPEFNRKAVDRFIGVAIPVLSLPITAVAVWA FT WWVTGRSPFWSLAIGILSIVALTGSIVAEKFYKNLDLSESLLLTSYPLIASAAALVTPL FT PNGVDSLGPPQVAAAAAAVLFLTLLTRGGARRHSGYASFTAITTIAIVVIAIAYGFGYQ FT HWVPTGAVAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVVTPHEATHEE FT TPTWQAIIASVPDSAVRLTERSSLAKRLLIGYVISGTLILCSGAIAVIVRGHFFAHSLV FT VAFLLTVVCTFRSRLYAERWCAWALLAAAVVIPTGLTVKLCIWYTQIAWLLLTSYLVAA FT IIALMVFGATVRVRRVSPVTKRIMELIDGAVVASIIPLLLWIAGVYDMVRNLSF" FT CDS complement(59555..61315) FT /transl_table=11 FT /gene="ML0048" FT /product="conserved hypothetical protein" FT /note="Has a proline-rich N-terminus. Similar to several FT proteins from M. tuberculosis, some of which also contain FT proline-rich regions e.g. M.tuberculosis Rv3876, FT hypothetical protein, TR:O69740 (EMBL:AL123456) (666 aa); FT Fasta score E(): 0, 50.7% identity in 672 aa overlap, and FT Rv0530, hypothetical protein, TR:O06396 (EMBL:AL123456) FT (405 aa); Fasta score E(): 1.3e-19, 30.5% identity in 417 FT aa overlap. Similar to the C-terminal half of Streptomyces FT coelicolor SC3C3.03C, hypothetical protein, TR:O86637 FT (EMBL:AL031231) (1083 aa); Fasta score E(): 5.9e-27, 31.6% FT identity in 580 aa overlap, which contains Pro-Gln repeats. FT Previously sequenced as TR:O33082 (EMBL:Y14967) (478 aa); FT Fasta score E(): 0, 100.0% identity in 478 aa overlap." FT /note="C-terminal half is similar to that of ML0798" FT /db_xref="UniProtKB/TrEMBL:Q9CDD8" FT /protein_id="CAC29556.1" FT /translation="MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTP FT NGEVASPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAPPRSP FT AASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATPMPMTPIDGSQRTP FT VTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRPSANQHSRHARRGHHHRDETQQA FT NPASATEPMIAPRARTAELRQAPHAAAEPAPTQHLTRPDGLVSHRTALHDSTATSAIGV FT QTGRSTGAKKPSKVVAKRGWRHWVHTVTRINLGLSPDERYELDLRTRVRRPPRGSYQIG FT ILGLKGGAGKTTVTVTLGSMFARVRNDRILVVDADTSCGNLADRAGRFSEANIADLLAD FT KDVKSYNDIRTHTSVNAVNLEVLPAAEYSTAQHALSGEDWNFAAATVSKYYNVMLADCG FT VGLFDPVTRGVLSTASGVVIVTSTSVDAARQAAIALDWLRHNGYQDLLSRACVVINHVM FT PKEPNIASKDLVQQFEQQIQPGRVVVLPWDKHIAAGTEIRLDRLDPLYRRRILELAAAL FT SDDFERAGRH" FT CDS complement(61406..61693) FT /transl_table=11 FT /gene="ML0049" FT /product="possible secreted protein" FT /note="Similar to M. tuberculosis ESAT6, Rv3875, 6 KDa FT early secretory antigenic target, SW:ESA6_MYCTU (Q57165) FT (94 aa); Fasta score E(): 4.2e-10, 36.3% identity in 91 aa FT overlap. Also shows weak similarity to others e.g. FT M.tuberculosis CFP7, Rv0288, 10 KDa antigen, SW:CFP7_MYCTU FT (O53693) (95 aa); Fasta score E(): 0.17, 25.6% identity in FT 78 aa overlap. Other members of this family include FT Rv3019c, hypothetical protein, TR:O53266 and Rv3444c, FT hypothetical protein, TR:O06261. Previously sequenced as FT SW:ESA6_MYCLE (Q50206) (95 aa); Fasta score E(): 0, 100.0% FT identity in 95 aa overlap." FT /db_xref="GOA:Q50206" FT /db_xref="InterPro:IPR010310" FT /db_xref="UniProtKB/Swiss-Prot:Q50206" FT /protein_id="CAC29557.1" FT /translation="MIQAWHFPALQGAVNELQGSQSRIDALLEQCQESLTKLQSSWHGS FT GNESYSSVQRRFNQNTEGINHALGDLVQAINHSAETMQQTEAGVMSMFTG" FT RBS complement(61700..61703) FT /note="possible RBS" FT CDS complement(61720..62022) FT /transl_table=11 FT /gene="ML0050" FT /product="possible secreted protein" FT /note="Similar to M. tuberculosis lhp, Rv3874, culture FT filtrate protein 10 kDa CFP-10, TR:O69739 (EMBL:AF004671) FT (100 aa); Fasta score E(): 1.8e-10, 40.0% identity in 100 FT aa overlap. Also shows weak similarity to others e.g. M. FT tuberculosis Rv1197, hypothetical protein, TR:O05299 FT (EMBL:AL123456) (98 aa); Fasta score E(): 0.061, 21.9% FT identity in 96 aa overlap, and Rv1038c, hypothetical FT protein, TR:P96363 (EMBL:AL123456) (98 aa); Fasta score FT E(): 0.084, 21.9% identity in 96 aa overlap. These and FT others form a protein family typically found downstream of FT a member of the ESAT6 family. Other members include . FT Previously sequenced as TR:O33084 (EMBL:Y14967) (100 aa); FT Fasta score E(): 0, 100.0% identity in 100 aa overlap." FT /db_xref="UniProtKB/Swiss-Prot:O33084" FT /protein_id="CAC29558.1" FT /translation="MAEMITEAAILTQQAAQFDQIASGLSQERNFVDSIGQSFQNTWEG FT QAASAALGALGRFDEAMQDQIRQLESIVDKLNRSGGNYTKTDDEANQLLSSKMNF" FT CDS complement(62201..63109) FT /transl_table=11 FT /gene="ML0051" FT /product="PPE-family protein" FT /note="Similar to PPE-family proteins from M. tuberculosis FT e.g. Rv3873, PPE-family protein, TR:O69738 (EMBL:AL123456) FT (368 aa); Fasta score E(): 6.1e-32, 46.2% identity in 288 FT aa overlap. Lacks the PPE motif at the N-terminus. FT Previously sequenced as TR:O33085 (EMBL:Y14967) (302 aa); FT Fasta score E(): 0, 100.0% identity in 302 aa overlap. FT Contains Pfam match to entry PF00823 PPE, PPE family." FT /note="N-terminus is similar to the N-termini of ML0539, FT ML1828 and ML1991" FT /db_xref="InterPro:IPR000030" FT /db_xref="UniProtKB/TrEMBL:O33085" FT /protein_id="CAC29559.1" FT /translation="MTWPMLWPASVPSECPPNYWHTPAPSAKCEPEQAAVAPIAAAKPM FT ITWLQSAAEQTTTQAEAHRQAMASTPGMAVITENHITQAILATINFFGINMAPIAFTEA FT GDFICMRTQTALAMNSYQAETLLNTAFQKLEPMAAILNPSSYSPPSALTSQVNQFTQMI FT SGFSAALPSTQVLQQTVGQVAELARPMQQVKSLFTSIDSTGVYTSAQRGDTESAHRIGL FT FGASTLSSHPLVGITGTTTDTRLLCAESLPSASGSLAWTPLMTQFQLIDKSIAPEPRQR FT VMLPPWAAGSPGHNAQDGGTT" FT misc_feature complement(62720..63082) FT /note="Pfam match to entry PF00823 PPE, PPE family, score FT -37.40, E-value 1e-05" FT RBS complement(63118..63121) FT /note="possible RBS" FT CDS complement(63319..65112) FT /transl_table=11 FT /gene="ML0052" FT /product="conserved hypothetical protein" FT /note="Similar to putative ATP/GTP-binding proteins from M. FT tuberculosis and Streptomyces coelicolor e.g. M. FT tuberculosis Rv3871, hypothetical protein, TR:O69736 FT (EMBL:AL123456) (591 aa); Fasta score E(): 0, 80.9% FT identity in 596 aa overlap. In several of these cases this FT protein is similar to the C-terminal half of a larger FT protein, while the upstream ML0053 is similar to the FT corresponding N-terminal half e.g. M. tuberculosis Rv3447c, FT unknown membrane protein, TR:O06264 (EMBL:AL123456) (1236 FT aa); Fasta score E(): 0, 35.2% identity in 588 aa overlap FT and Streptomyces coelicolor SC3C3.20C, ATP/GTP binding FT protein, TR:O86653 (EMBL:AL031231) (1321 aa); Fasta score FT E(): 0, 35.0% identity in 575 aa overlap. Related proteins FT are also found in Bacillus spp. Previously sequenced as FT TR:O33086 (EMBL:Y14967) (597 aa); Fasta score E(): 0, 99.7% FT identity in 597 aa overlap. Contains 2 Pfam matches to FT entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains 2 FT x PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="Similar to the C-terminal halves of ML1543 and FT ML2535" FT /db_xref="GOA:Q9CDD7" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q9CDD7" FT /protein_id="CAC29560.1" FT /translation="MTAEPEVRALREVVLEQLGTGESLAYKMWLPPLLDPLPLNELIER FT DSNRHPLHFALGIMDEPRRHRQDIWGVDLSGAGGNIGIGGAPQTGKTTLLQTMVMSAAA FT THSPRDVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDRINRVIAEAQAVMRQREITFK FT ENRVGSMAAYRQLRTNRSHPVAADPFGDVFLIIDGWSAFTSEFPDLEAAVQDLAAQGLS FT FGVHTVITTPRWTELRSRVRDYLGTKIEFRLGDVNDTQIDRIARDIPANRPGRAISVEK FT HHLMMGVPRFDGAHSADDLVDAMTAGVAQIAAKTTEQAPRVRVLPSQVYLQEIDPNPPG FT PDSDYRTRWTIPVGVRETDLSVAYAHMSSNPHLLIFGNSKSGKTRIVHAIARAICARNS FT PKQVRFMLADYRSSLLDAVPDSHLLDAGAINRNSASLDEAIRALTTNLKKRLPPADLTT FT AQVRSRSWWSGFDVVLLVDDWHMIVSAAGSAPPMGPLAPLLPAAPDIGLHILVTCLMSQ FT AYKATMDKFVGSAFGAGAPTIFLSGDKQEFPSSEIKVKRRPPGQAFMVSPEAKEVIQAV FT YVDPPEVDPPKEVFAVPPASS" FT misc_feature complement(63559..64119) FT /note="Pfam match to entry PF01580 FtsK_SpoIIIE, FT FtsK/SpoIIIE family, score 178.70, E-value 9.4e-50" FT misc_feature complement(63961..63984) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature complement(64234..64992) FT /note="Pfam match to entry PF01580 FtsK_SpoIIIE, FT FtsK/SpoIIIE family, score 162.10, E-value 9.2e-45" FT misc_feature complement(64837..64860) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT RBS complement(65124..65127) FT /note="possible RBS" FT CDS complement(65186..67420) FT /transl_table=11 FT /gene="ML0053" FT /product="putative membrane protein" FT /note="Similar to putative ATP/GTP-binding proteins from M. FT tuberculosis and Streptomyces coelicolor e.g. M. FT tuberculosis Rv3870, hypothetical protein, TR:O69735 FT (EMBL:AL123456) (747 aa); Fasta score E(): 0, 85.4% FT identity in 746 aa overlap. In several of these cases this FT protein is similar to the N-terminal half of a larger FT protein, while the downstream ML0052 is similar to the FT corresponding C-terminal half e.g. M.tuberculosis Rv3447c, FT unknown membrane protein, TR:O06264 (EMBL:AL123456) (1236 FT aa); Fasta score E(): 0, 37.2% identity in 732 aa overlap FT and Streptomyces coelicolor SC3C3.20C, ATP/GTP binding FT protein, TR:O86653 (EMBL:AL031231) (1321 aa); Fasta score FT E(): 0, 34.7% identity in 760 aa overlap. Related proteins FT are also found in Bacillus spp. Contains hydrophobic, FT possible membrane-spanning region near the N-terminus. FT Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FT FtsK/SpoIIIE family. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /note="Similar to the N-terminal halves of ML1543 and FT ML2535" FT /db_xref="GOA:O33087" FT /db_xref="InterPro:IPR002543" FT /db_xref="UniProtKB/TrEMBL:O33087" FT /protein_id="CAC29561.1" FT /translation="MTTKKFTPTITRGPRLTPGEINITPPDDLGLEIPPSGIQKILPYV FT MVGCIVGMIAIMVLGGTKQLSPYMLMMPIMMVMMMAGGSGGGGGGKKVPEINADRKEYL FT RYLAGLRARVTSSAASQVAFFSYHAPHPQDLLSIVGTQRQWSRPANADFYAATRIGVGD FT QPAVDRLLKPAVGGELTASGAAPQPFLEPVSHMWVVKFLRTHGLVHDCPKLLQMRTFPT FT IAVGGDTAGAGGLLTAMICHLAVFHPPDLLQIRVLTEKPDDPNWSWLKWLPHIQHPTET FT DAAGAARMIFTRSDSLADLMSRGPHAPDSLPGGPYVILVDLTGGKAGFPPDGRAGVTVI FT TLGNHRSSTYRIRVNKNGTADDRLPGQSFRQVTSTVDHLSKAEATRIARKLAGWSITGT FT ILDKTSRVQKKVATEWHQLVGANTVEEVLPSRWRMYTDNDRDRLKIPFGHEFKTGNIMY FT LDIKEGAEFGGGPHGMLIGTTGSGKSEFLRTLILSLVAMTHPNQVNLLLTDFKGGSTFL FT GMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQNILRQAGTLVGAAGALSGVAEY FT EKYRERGANLAPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQ FT TGGVRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNKESGVGFLRIGMEDPVKF FT SSLYTGIPFVPAIATETNGDSSPSSPWASRKKVHIYEFTAAPILESTTTS" FT misc_feature complement(65513..66145) FT /note="Pfam match to entry PF01580 FtsK_SpoIIIE, FT FtsK/SpoIIIE family, score 250.40, E-value 2.4e-71" FT misc_feature complement(65969..65992) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(67417..68862) FT /transl_table=11 FT /gene="ML0054" FT /product="putative membrane protein" FT /note="Similar to several M. tuberculosis hypothetical FT proteins e.g. Rv3869, conserved hypothetical protein, FT TR:O69734 (EMBL:AL123456) (480 aa); Fasta score E(): 0, FT 75.7% identity in 478 aa overlap. Previously sequenced as FT TR:O33088 (EMBL:Y14967) (481 aa); Fasta score E(): 0, FT 100.0% identity in 481 aa overlap. Contains hydrophobic, FT possible membrane-spanning region near the N-terminus." FT /note="Similar to ML1544 and ML2536" FT /db_xref="InterPro:IPR007795" FT /db_xref="UniProtKB/TrEMBL:O33088" FT /protein_id="CAC29562.1" FT /translation="MGLRLTTKVQVSGWRFLLRRVEHAIVRRDTRMFDDPLQFYSRSIA FT LGIVVAVALLIGAVLLAYFKPQGKLGASTLLTDRATNQLYVLLSGHLYPVYNLTSARLA FT LGKPANPAAVKSSELTKLPIGQTIGIPGAPYATPVSGDSSSTWTLCDTVAKIESESPAV FT QTSVIARSLQIDPAINPLQPNEALLASYRDKTWLVNSKGRHSIDLADRALTSAIGISVN FT VKPTPLSEGLFNALPDVGRWELPTIPDTGAPNSLGLSPDLVIGSVFQIQMEKSPQYYVV FT LSDGIAQVNATTADALRATQSHGLVAPPSLVPNVVVQIPERVYDSPLPDEPLKMVARDD FT YPTLCWAWERKASDQAPKRTMLIGQHLPLQPSAMSTGIKQIRGTATVYIDGGRYVALQS FT PDPRYSESLYYVDPEGVRYGLANSEAVKALGLASPQTAPWVIVRLLVEGPVLSRDAALL FT EHDTLIADPSPRKVPAGYSGVRP" FT RBS complement(67428..67431) FT /note="possible RBS" FT CDS complement(68866..70587) FT /transl_table=11 FT /gene="ML0055" FT /product="conserved hypothetical protein" FT /note="Similar to several M. tuberculosis hypothetical FT proteins e.g. Rv3868, hypothetical protein, SW:Y2G8_MYCTU FT (O69733) (573 aa); Fasta score E(): 0, 89.2% identity in FT 573 aa overlap. C-terminus is similar to many members of FT the CBXX/CFQX family e.g. Bacillus subtilis SpoVK/SpoVJ, FT stage V sporulation protein, SW:SP5K_BACSU (P27643) (322 FT aa); Fasta score E(): 3.5e-26, 33.7% identity in 332 aa FT overlap. Previously sequenced as SW:Y2G8_MYCLE (O33089) FT (573 aa); Fasta score E(): 0, 100.0% identity in 573 aa FT overlap. Contains Pfam match to entry PF00004 AAA, ATPases FT associated with various cellular activities (AAA). Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="Similar to ML1536 and ML2537. Shows weak similarity FT to ML0798" FT /db_xref="GOA:O33089" FT /db_xref="HSSP:1IN4" FT /db_xref="InterPro:IPR000641" FT /db_xref="UniProtKB/Swiss-Prot:O33089" FT /protein_id="CAC29563.1" FT /translation="MIDRLGSLFESAASMLPMSEARSFELFTEITNYDETACDAWIGRI FT RCGDTDRVTLFRAWYSRRNFGQLSGSVQIPMTTLNARVPIGGLYGDITYPVTSPLAITM FT GFAACEAAQGNFADAMEAIDATSITGSEHLVAWLKAVVYGAAERWTDVIDEVKGAGKWP FT DKFLAGAAGVAHGVAAANLGLFTEAERRLTEANDSPAGEACARSIAWYLAMARRSQGNE FT DAAVALLEWLQTTHPESKVSAALKDPSYRLTTTTAEQIAARADPWDPSSVVTDNSDRDR FT LLTQAQAELDRQIGLTRVKTQIERYRAATMMAKVRAAKGMKVAQPSKHMIFTGPPGTGK FT TTIARVVANILAGLGVISEPKLVETSRKDFVAEYEGQSAVKAAKTIDLALGGVLFIDEA FT YALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFA FT TRIEFDTYSPDELLEIAKVIATDADSSLSAEASKNLLEAAKQLAQRTLRGRPALDVAGN FT GRYARQLVEAAEQCRDMRLARGVDIEQLDVDRLQEINGSDMAEAIATVHAHLNIRE" FT misc_feature complement(68872..69603) FT /note="Pfam match to entry PF00004 AAA, ATPases associated FT with various cellular activities (AAA), score 15.30, FT E-value 1.7e-06" FT misc_feature complement(69565..69588) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(70584..71093) FT /transl_table=11 FT /gene="ML0056" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3867, conserved FT hypothetical protein, TR:O06269 (EMBL:AL123456) (184 aa); FT Fasta score E(): 1.1e-12, 38.4% identity in 172 aa overlap FT and to Rv3614c, hypothetical protein, TR:O69732 FT (EMBL:AL123456) (183 aa); Fasta score E(): 1e-20, 48.2% FT identity in 166 aa overlap. Previously sequenced as FT TR:Q49730 (EMBL:U00015) (216 aa); Fasta score E(): 1.7e-13, FT 40.2% identity in 169 aa overlap." FT /note="Similar to ML0407" FT /db_xref="UniProtKB/TrEMBL:Q9CDD6" FT /protein_id="CAC29564.1" FT /translation="MNLLGNDDDNHLASLDFYSANRYYEESLFFDELDGYAPTTPVGIE FT ANDLDVFQSLTEPEEELEVELLAVTNPAKSVSALMNGRVHQVELTDQVTRIGEKKPATE FT AFVLASLARQKARTSQGTCILDSLQGGGENTTARCELVGLTLNLPTSEQAAAEAEMFSN FT NILRQK" FT CDS complement(71142..72064) FT /pseudo FT /transl_table=11 FT /gene="ML0057" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3866 (Best blastx score 427)" FT RBS complement(71605..71608) FT /note="possible RBS" FT repeat_region 71670..71773 FT /note="2 copies of 52 bp repeat, Consensus FT TTGTTGTTGCCAACATTGCGACGCCACTACCGAGTCTCCACTCCCGGTCCGG " FT CDS complement(72683..73686) FT /pseudo FT /transl_table=11 FT /gene="ML0058" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3864 (Best blastx score 110)" FT repeat_region 73074..73136 FT /note="3 copies of 21 bp repeat, Consensus FT GATCAAGCCAGGAATCAAGTT " FT CDS complement(73832..74366) FT /pseudo FT /transl_table=11 FT /gene="ML0059" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3863 (Best blastx score 119)" FT repeat_region complement(74457..75125) FT /note="Dispersed repeat, RLEP, copy 2" FT stem_loop complement(75139..75188) FT /note="50 bp palindrome" FT CDS complement(76494..76713) FT /pseudo FT /transl_table=11 FT /gene="ML0060" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3860 (Best blastx score 354)" FT CDS 77709..82292 FT /transl_table=11 FT /gene="gltB" FT /gene_synonym="ML0061" FT /product="putative ferredoxin-dependent glutamate synthase" FT /EC_number="1.4.1.13" FT /note="Similar to M. tuberculosis Rv3859c, putative FT ferredoxin-dependent glutamate synthase, TR:P96218 FT (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% FT identity in 1527 aa overlap and to Synechocystis sp. gltB, FT ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 FT (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in FT 1525 aa overlap. Contains Pfam match to entry PF01493 FT DUF14, Domain of unknown function. Contains Pfam match to FT entry PF01645 Glu_synthase, Conserved region in glutamate FT synthase. Contains PS00095 C-5 cytosine-specific DNA FT methylases C-terminal signature." FT /db_xref="GOA:Q9CDD5" FT /db_xref="HSSP:1LM1" FT /db_xref="InterPro:IPR006982" FT /db_xref="UniProtKB/TrEMBL:Q9CDD5" FT /protein_id="CAC29569.1" FT /translation="MTAKRVGLYNPAFEHDSCGVAMVVDMYGRRTRDIVDKAITALLNL FT EHRGAQGAEPRSGDGAGILIQVPDAFLRAVVDFELPAASSYATGIAFLPQSSKDAAAAC FT AAVEKIAVAEGLHVLGWRNVPTDASSLGALSRDAMPTFRQVFMAGATGLTLERRAYVIR FT KRAEHELGTKGPGQDGPGRETIYFPSLSSQTFVYKGMLTTPQLKAFYRDLQDERLTSAL FT GIVHSRFSTNTFPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALMKTDIFGSKADME FT KLFPICTPGASDTARFDEALELLHLGGRSLVHAVLMMIPEAWERHESMDPARRAFYQYH FT ASLMEPWDGPASMTFTDGVVVGAVLDRNGLRPSRIWITDAGLVVMASEAGVLDLDPSIV FT VRRMRLQPGRMFLVDTAQGRIVSDEEIKAKLAAEHPYQEWLDKGLVPIDELPAGKYVRM FT PHHRLVMRQLAFGYTYEELNLLVAPMVRAGSEPIGSMGADTPIAVLSRRPRMLYDYFHQ FT LFAQVTNPPLDAIREEVVTSLQGTTGGEYDLLSPDENSCHQIWLPQPILRNYELAKLVN FT LDPADEVNGRPHGMRSTVVSCLYPVADAGAGLAAALTEVRAQASAAIVGGARVIILSDR FT NSDEQMAPIPSLLSVAAVHHHLVRDRTRTHVGLVVESGDAREVHHMAALIGFGAAAVNP FT YLVFESIEEMLDRGVIDGIDRKTALNNYIKATGQGVLKIMSKMGISTLASYVGAQLFQA FT VGISEDVLDEYFSGLSCPTGGITLDDIAAEVAVRHRVAYLDRPDERAHRELEVGGEYQW FT RREGEYHLFNPETVFKLQHATRSGQYKIFKEYTRLVDDQSERMASLRGLLKFRSGVRTP FT VPLDEVEPASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGGRSNSGEGGEDVNRFEP FT DPNGDWRRSAIKQVASARFGVTSHYLTNCTDIQIKMAQGAKPGEGGQLPGRKVYPWIAQ FT VRNSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANPSARVHVKLVSENGVGTVAAGVS FT KAHADVVLVSGHDGGTGATPLTSMKHSGAPWELGLAETQQTLLLNGLRDRIVVQVDGQL FT KTGRDVMIAALLGAEEFGFATAPLVVAGCIMMRVCHLDTCPVGVATQNPLLRKRFNGKP FT EFVENFFMFIAEEVREYMAQLGFRTFNEAVGQVGALDTTPVREHWKAHSIDLTPVLHEP FT ESAFMNQDLYCSSRQDHGLDKVLDQQLIAVSRDALDFGKPVRFSTTIGNVNRTVGTMLG FT HELTKAYGAQGLPDGTIDITFEGSAGNSFGAFVPKGITLRVYGDANDYVGKGLSGGRIV FT VRPSDSVPLNYVAEDNIIGGNVILFGATSGEVYLRGVVGERFAVRNSGAHAVVEGVGDH FT GCEYMTGGKVVILGRTGRNFAAGMSGGEAYVYDSDGELPANLNFEMVELEPLDFDDAAW FT LYATIQAHVDATDSAVGQRILAGWSEQQRYFVKVMPKDYKRVLQAIALAERNGVDVNKV FT IMEPAHG" FT misc_feature 80163..81278 FT /note="Pfam match to entry PF01645 Glu_synthase, Conserved FT region in glutamate synthase, score 778.30, E-value FT 3.1e-230" FT misc_feature 81510..82103 FT /note="Pfam match to entry PF01493 DUF14, Domain of unknown FT function, score 324.10, E-value 1.6e-93" FT misc_feature 81627..81683 FT /note="PS00095 C-5 cytosine-specific DNA methylases FT C-terminal signature" FT RBS 82274..82277 FT /note="possible RBS" FT CDS 82285..83751 FT /transl_table=11 FT /gene="gltD" FT /gene_synonym="ML0062" FT /product="NADH-dependent glutamate synthase small subunit" FT /EC_number="1.4.1.13" FT /note="Similar to M. tuberculosis Rv3858c, gltD, putative FT NADH-dependent glutamate synthase small subunit, TR:P96219 FT (EMBL:Al123456) (488 aa); Fasta score E(): 0, 87.7% FT identity in 488 aa overlap and to many other putative FT glutamate synthase small subunits e.g. Escherichia coli FT gltD, glutamate synthase [NADPH] small chain, SW:GLTD_ECOLI FT (P09832) (471 aa); Fasta score E(): 0, 37.8% identity in FT 474 aa overlap. Contains Pfam match to entry PF00070 FT pyr_redox, Pyridine nucleotide-disulphide oxidoreductase." FT /db_xref="GOA:Q9CDD4" FT /db_xref="InterPro:IPR006005" FT /db_xref="UniProtKB/TrEMBL:Q9CDD4" FT /protein_id="CAC29570.1" FT /translation="MADPAGFLKYTQRELPRRRPVPLRLRDWKELYEEFDKETLRNQAS FT RCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWHDAVERLHATNNFPDVTGRLCPAPCES FT ACVLGINQDPVTIKQIELEIIDKAFDEGWVQPLPPQQLTGKTVAVVGSGPAGLAAAQQL FT TRAGHRVTVFERDDRIGGLLRYGIPEFKMEKRFLERRLDQLRAEGTEFRSGVNVGVDIT FT ADQLCADFDAVVLAGGAATWRELPIPGRELDGVHQAMEFLPWVNRVQEGDDVLGDDGQP FT PITAKDKKVVIIGGGDTGADCLGAVHRQGAIHVHQLEIMPRPPDARAASTPWPTYPLMY FT RVSPAHEEGGERVFSVNTEEFVGKNGRVHALKAHEVTMQDGRFVKVENSVFELEADLVL FT LAMGFVGPEKPGLLTDLGVKFTDRGNVARGADFDTSVPGVFVAGDMGRGQSLIVWAIAE FT GRAAAAAVDRFLMGATALPAPVKPSSLPLQ" FT misc_feature 82723..83619 FT /note="Pfam match to entry PF00070 pyr_redox, Pyridine FT nucleotide-disulphide oxidoreductase, score 114.20, E-value FT 6e-33" FT CDS 84980..85727 FT /pseudo FT /transl_table=11 FT /gene="ML0063" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3856c (Best blastx score 211)" FT CDS complement(85968..86612) FT /transl_table=11 FT /gene="ML0064" FT /product="putative transcriptional regulator" FT /note="Similar to M. tuberculosis Rv3855, putative FT transcriptional regulator, TR:P96222 (EMBL:Al123456) (216 FT aa); Fasta score E(): 0, 77.0% identity in 213 aa overlap. FT Contains a probable helix-turn-helix motif at aa 45-66 FT (Score 1261, SD +3.48) Contains Pfam match to entry PF00440 FT tetR, Bacterial regulatory proteins, tetR family." FT /note="Similar to ML1070" FT /db_xref="GOA:Q9CDD3" FT /db_xref="InterPro:IPR012287" FT /db_xref="UniProtKB/TrEMBL:Q9CDD3" FT /protein_id="CAC29572.1" FT /translation="MINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEI FT SVDYLAKSAGISRPTFYFYFASKEAVLLTLLDRVFNKANAALETLIKNRDNKRGNKWRT FT GINVFFETFGSHKAVTCAGQVTRDNTEVRKLWSTFMQKWISYTAAVIDAERKRGVAPDT FT LPATELATALNLMNERALFASFTAEQPHVPESRVLDTLVHIWVSSIYNEIR" FT misc_feature complement(86388..86528) FT /note="Pfam match to entry PF00440 tetR, Bacterial FT regulatory proteins, tetR family, score 56.20, E-value FT 5.6e-13" FT CDS 86681..88165 FT /transl_table=11 FT /gene="ML0065" FT /product="putative monooxygenase" FT /note="Similar to putative monooxygenases from M. FT tuberculosis e.g. Rv3854c, probable monooxygenase, FT TR:P96223 (EMBL:AL123456) (489 aa); Fasta score E(): 0, FT 80.1% identity in 488 aa overlap. Others are Rv0892 and FT Rv1393c. Also similar to the C-terminal half of Deinococcus FT radiodurans plasmid MP1 DRB0033, putative FT arylesterase/monoxygenase, TR:Q9RZT0 (EMBL:AE001826) (833 FT aa); Fasta score E(): 0, 51.5% identity in 480 aa overlap. FT Shows weaker similarity to Rhodococcus rhodochrous steroid FT monooxygenase, TR:O50641 (EMBL:AB010439) (549 aa); Fasta FT score E(): 2e-15, 24.9% identity in 469 aa overlap. FT Contains Pfam match to entry PF00743 FMO-like, FT Flavin-binding monooxygenase-like." FT /note="Similar to pseudogene ML1732" FT /db_xref="GOA:Q7AQN8" FT /db_xref="InterPro:IPR013027" FT /db_xref="UniProtKB/TrEMBL:Q7AQN8" FT /protein_id="CAC29573.1" FT /translation="MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAG FT MGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKPILEYIKSTAVMHGIDKYIR FT LNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFT FT GPIIHPQHWPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPA FT KDKIAARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGY FT DVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSGNELRA FT DIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLK FT ADLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRT FT PWRLNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV" FT misc_feature 86714..88111 FT /note="Pfam match to entry PF00743 FMO-like, Flavin-binding FT monooxygenase-like, score -279.10, E-value 1.7e-07" FT CDS complement(88246..88719) FT /transl_table=11 FT /gene="menG" FT /gene_synonym="ML0066" FT /product="putative FT S-adenosylmethionine:2-demethylmenaquinone FT methyltransferase" FT /note="Similar to M. tuberculosis Rv3853, menG, putative FT S-adenosylmethionine:2-demethylmenaquinone FT methyltransferase, TR:P96224 (EMBL:AL123456) (157 aa); FT Fasta score E(): 0, 87.1% identity in 155 aa overlap. FT Similar to Escherichia coli menG, FT S-adenosylmethionine:2-demethylmenaquinone FT methyltransferase, SW:MENG_ECOLI (P32165) (161 aa); Fasta FT score E(): 2.4e-20, 45.6% identity in 149 aa overlap." FT /db_xref="GOA:Q9CDD2" FT /db_xref="HSSP:1NXJ" FT /db_xref="InterPro:IPR010203" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDD2" FT /protein_id="CAC29574.1" FT /translation="MIVSFRPTADLVDSIGVDVRSCDLQFRQFGGCSEFAGPISTVRCF FT QDNALLKSVLSQTSAGGVLVVDGAGSLHTALVGDVIAELAHSNGWAGLIVNGAVRDAAA FT LRGIDIGIKALGTNPRKSTKIGTGERHVEVNLGGVTFVPGEVVYSDDDGIVVV" FT CDS complement(88741..89106) FT /transl_table=11 FT /gene="hns" FT /gene_synonym="ML0067" FT /product="histone-like protein" FT /note="Similar to M. tuberculosis Rv3852, hns, HU-histone FT protein, TR:P96225 (EMBL:AL123456) (134 aa); Fasta score FT E(): 6.1e-12, 51.5% identity in 134 aa overlap. Contains FT PAKKX repeats similar to those in histone H1 proteins." FT /db_xref="UniProtKB/TrEMBL:Q9CDD1" FT /protein_id="CAC29575.1" FT /translation="MADQQNPPNSEPDGTSTLPAKKVPAKAAKAPAKKAPPKSPSFASP FT QAANQSLGLQQRIETNGQLDVAKDVAEQAQSAVEGASNPVPNGAEALEASNSPVALVIA FT LAIGLLALLLIHQLRRR" FT RBS complement(89114..89118) FT /note="possible RBS" FT CDS complement(89620..90336) FT /transl_table=11 FT /gene="ML0068" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3850, hypothetical FT protein, TR:P96227 (EMBL:AL123456) (218 aa); Fasta score FT E(): 0, 78.3% identity in 217 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CDD0" FT /protein_id="CAC29576.1" FT /translation="MGLFHKRRSRAMRRAEARAIKARAKLEARLAAKNEARRLNSAQRA FT TNKALKAQLKAKRNSDRVALKVAETELKAAKEGKLLSPTRIRRVLTVSRLLAPIVVPLI FT YRAAIATRALIDQRRADQLGIPLAQIGQFSGPSARLSARIARSEQSVLLVQEKKPKDAE FT TKQFVSTITERLIDLSAAVAAVENMPATRRRAVHSTISSQLDGIEADLMARLGVDLTTS FT MADNRSVADSTRKAAT" FT RBS complement(90347..90351) FT /note="possible RBS" FT CDS complement(90521..90919) FT /transl_table=11 FT /gene="ML0069" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3849, hypothetical FT protein, TR:P96228 (EMBL:AL123456) (132 aa); Fasta score FT E(): 0, 84.0% identity in 131 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CDC9" FT /protein_id="CAC29577.1" FT /translation="MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYL FT SQLRSGNRTNPSSATISALANFFRIKPAYFTNDEYYEKLDQELAWLATMRDEGVRRIAM FT RTIGLSAQAQQDIVDRVDELRRAEHLDV" FT RBS complement(90927..90932) FT /note="possible RBS" FT CDS complement(91296..91559) FT /transl_table=11 FT /gene="ML0070" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CDC8" FT /protein_id="CAC29578.1" FT /translation="MLTGVTNLLVPSVRLVAAGQHAVGGGPVVIGVNAALALATGKCRY FT VAHSALATNKSNNRWETTGRRLDIPSSTRADHQAVPNSPHRE" FT CDS complement(91913..92446) FT /transl_table=11 FT /gene="ML0071" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3847, hypothetical FT protein, TR:P96230 (EMBL:AL123456) (177 aa); Fasta score FT E(): 0, 96.6% identity in 177 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CDC7" FT /protein_id="CAC29579.1" FT /translation="METGSGLPIGVVPFHARGALKGFVISGRWPDSTKEWAQLLMVAVR FT IASLPGLLSTTTVFGAREELPDEPEPGTVGLVLAEGTVFGESAIQPGYFADHQPPALLM FT LHPPSETMPSLPECTGAASGCVLLPGLPYLGLEHRAAWVEAEADGTITSMVSRVGVDPI FT SHPDTAILAMLLAA" FT RBS complement(92452..92456) FT /note="possible RBS" FT CDS complement(92647..93270) FT /transl_table=11 FT /gene="sodA" FT /gene_synonym="ML0072" FT /product="superoxide dismutase" FT /EC_number="1.15.1.1" FT /note="Similar to M. tuberculosis Rv3846, sodA, superoxide FT dismutase, SW:SODF_MYCTU (P17670) (207 aa); Fasta score FT E(): 0, 80.1% identity in 206 aa overlap, and to many other FT mycobacterial superoxide dismutases. Previously sequenced FT as SW:SODM_MYCLE (P13367) (206 aa); Fasta score E(): 0, FT 100.0% identity in 206 aa overlap. Contains Pfam match to FT entry PF00081 sodfe, Iron/manganese superoxide dismutases FT (SODM). Contains PS00088 Manganese and iron superoxide FT dismutases signature." FT /db_xref="GOA:P13367" FT /db_xref="HSSP:1IDS" FT /db_xref="InterPro:IPR019831" FT /db_xref="UniProtKB/Swiss-Prot:P13367" FT /protein_id="CAC29580.1" FT /translation="MAEYTLPDLDWDYAALEPHISGEINEIHHTKHHAAYVKGVNDALA FT KLDEARAKDDHSAIFLNEKNLAFHLGGHVNHSIWWKNLSPNGGDKPTGGLATDIDETFG FT SFDKFRAQFSAAANGLQGSGWAVLGYDTLGNKLLTFQLYDQQANVSLGIIPLLQVDMWE FT HAFYLQYKNVKADYVKAFWNVVNWADVQSRYMAATSKTQGLIFD" FT misc_feature complement(92674..93264) FT /note="Pfam match to entry PF00081 sodfe, Iron/manganese FT superoxide dismutases (SODM), score 427.70, E-value 1e-124" FT misc_feature complement(92770..92793) FT /note="PS00088 Manganese and iron superoxide dismutases FT signature" FT RBS complement(93277..93285) FT /note="possible RBS" FT CDS 94092..95126 FT /transl_table=11 FT /gene="ML0073" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3843c, putative FT membrane protein, TR:P96235 (EMBL:Z83864) (342 aa); Fasta FT score E(): 0, 63.0% identity in 349 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CDC6" FT /protein_id="CAC29581.1" FT /translation="MIQVCSQCGTRWNVRERRREWCLRCRGALIAPQAEMPTAVKQWSS FT HVGLPAGIVPEALGWQRTPPGFRWIAVRPGAAPPNRRRQRHHVPTPRYAVMPRWGLADR FT VDQDSTWIQAPLKPGPSSAKVRTTLFVAVLVFTLAALVYVVRYVLLVINRNTLLNFGVA FT AIADWLGVIASLAAIAATLACVMALSRWLIARRAAAYAHHAVPEQRSSWELRAGCLLPL FT VNLLWAPVYVIELALMENHYTQLQKPIFMWWIVWVFSYVISVVAVVTSWAKDAQGIANN FT TVAMVFAYLFAAAAVAAVARVFEGFECKSIKRPVHRWVVVHLGGSVVHPSPGSVELEGQ FT EPAA" FT CDS 95132..95947 FT /transl_table=11 FT /gene="glpQ" FT /gene_synonym="ML0074" FT /product="putative glycerophosphoryl diester FT phosphodiesterase" FT /EC_number="3.1.4.46" FT /note="Similar to M. tuberculosis Rv3842c, glpQ1, FT glycerophosphoryl diester phosphodiesterase, TR:P96236 FT (EMBL:AL123456) (274 aa); Fasta score E(): 0, 88.8% FT identity in 269 aa overlap. Similar to Bacillus subtilis FT glpQ, glycerophosphoryl diester phosphodiesterase, FT SW:GLPQ_BACSU (P37965) (293 aa); Fasta score E(): 2.3e-20, FT 32.0% identity in 250 aa overlap." FT /db_xref="GOA:Q9CDC5" FT /db_xref="InterPro:IPR017946" FT /db_xref="UniProtKB/TrEMBL:Q9CDC5" FT /protein_id="CAC29582.1" FT /translation="MMLADEVFAGHPFVVAHRGASAVLPEHTLAAYELALKEGADGVEC FT DVRLTRDGHMVCVHDRRLDRTSTGVGLVSTMTLAQLRALEYGAWHNSWRPDGTHGDTGL FT LTLDALVSLVLDWHRPVKIFVETKHPVRYGALVESKLLALLHRFGIAAPASADRSRAVV FT MSFSAAAVWRVRRAAPLLPTVLLGRAGRYLTSSAATAVGATAVGPSLPALKEYPKLVDR FT AGAQGRAVYCWNVDDYDDIDFCRDIGVAWIATRHPGRTKAWLQNNGRTE" FT CDS complement(95965..96439) FT /pseudo FT /transl_table=11 FT /gene="bfrB" FT /gene_synonym="ML0075" FT /product="bacterioferritin (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT bfrB (Best blastx score 190)" FT CDS complement(97037..97282) FT /pseudo FT /transl_table=11 FT /gene="ML0076" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3840 (Best blastx score 196)" FT CDS complement(97832..98119) FT /pseudo FT /transl_table=11 FT /gene="ML0077" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3839 (Best blastx score 251)" FT CDS 98425..99393 FT /transl_table=11 FT /gene="pheA" FT /gene_synonym="ML0078" FT /product="putative prephenate dehydratase" FT /EC_number="4.2.1.51" FT /note="Similar to M. tuberculosis Rv3838c, pheA, prephenate FT dehydratase, TR:P96240 (EMBL:AL123456) (321 aa); Fasta FT score E(): 0, 83.9% identity in 311 aa overlap. Similar to FT Amycolatopsis methanolica pheA, prephenate dehydratase, FT SW:PHEA_AMYME (Q44104) (304 aa); Fasta score E(): 0, 44.4% FT identity in 315 aa overlap. Contains Pfam match to entry FT PF01842 ACT, ACT domain. Contains Pfam match to entry FT PF00800 PDT, Prephenate dehydratase. Contains PS00858 FT Prephenate dehydratase signature 2." FT /db_xref="GOA:Q9CDC4" FT /db_xref="InterPro:IPR018528" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDC4" FT /protein_id="CAC29586.1" FT /translation="MSVARIAYLGPEGTFTEAALLRMTAAGLVPDTGPDGLRRWPTEST FT PAALDAVRGGAADYACVPIENSIDGSVAPTLDNLAIGSPLQVFAETTLDVEFNIVVKPG FT ITAADIRTLAAFPVAAAQVRQWLAAHLAGAELRPAYSNADAARQVAYGQVDAAVTSPLA FT ATRWGLIALAAGIVDEPNARTRFVLVGMPGPPPARTGTDRTSAVLRIDNAPGMLVAALA FT EFGIRGIDLTRIESRPTRTELGTYLFFVDCVGHIDDGVVAEALKALHRRCADVCYLGSW FT PAGLATGPTVSPPPPDEASRWLARLRAGKPDQASEPGGGKL" FT misc_feature 98440..99006 FT /note="Pfam match to entry PF00800 PDT, Prephenate FT dehydratase, score 313.20, E-value 3e-90" FT misc_feature 99034..99267 FT /note="Pfam match to entry PF01842 ACT, ACT domain, score FT 55.20, E-value 1.4e-12" FT misc_feature 99115..99138 FT /note="PS00858 Prephenate dehydratase signature 2" FT CDS 99390..100085 FT /transl_table=11 FT /gene="ML0079" FT /product="putative phosphoglycerate mutase" FT /note="Similar to M. tuberculosis Rv3837c, putative FT phosphoglycerate mutase, TR:P96241 (EMBL:AL123456) (232 FT aa); Fasta score E(): 0, 71.6% identity in 232 aa overlap. FT Similar to Amycolatopsis methanolica pgm, 2,3-PDG dependent FT phosphoglycerate mutase, TR:Q9ZAX0 (EMBL:U73808) (205 aa); FT Fasta score E(): 9.3e-24, 39.7% identity in 204 aa overlap. FT Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate FT mutase family. Contains PS00175 Phosphoglycerate mutase FT family phosphohistidine signature." FT /note="Similar to ML1452" FT /db_xref="InterPro:IPR013078" FT /db_xref="UniProtKB/TrEMBL:Q9CDC3" FT /protein_id="CAC29587.1" FT /translation="MSSRLVLLRHGQSYGNVEGRLDTRPPGASLTPFGRDQARVFAQAA FT GRPVLLVHSVAIRALETAAVLGAEFDVPIREIAGIHEVQVGELENRNDDDAIAEFNAIY FT DRWHHGELDVPLPGGETANDVLDRYLPVLVDLRMRYLDDGDWTGDVVVVSHGAAIRLVS FT AVLAEVDGRFALENRVNNAESVVLVPVTDGRWSCVRWGALTPPFYPHLHRPDSTLVTDV FT VMSGRDSLG" FT misc_feature 99405..99869 FT /note="Pfam match to entry PF00300 PGAM, Phosphoglycerate FT mutase family, score 27.40, E-value 2e-06" FT misc_feature 99408..99437 FT /note="PS00175 Phosphoglycerate mutase family FT phosphohistidine signature" FT CDS complement(100374..100651) FT /pseudo FT /transl_table=11 FT /gene="ML0080" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3836 (Best blastx score 137)" FT CDS complement(100648..102000) FT /transl_table=11 FT /gene="ML0081" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3835c, hypothetical FT protein, TR:P96243 (EMBL:AL123456) (449 aa); Fasta score FT E(): 0, 69.4% identity in 457 aa overlap. Contains FT hydrophobic, possible membrane-spanning region near the FT N-terminus." FT /db_xref="UniProtKB/TrEMBL:Q9CDC2" FT /protein_id="CAC29589.1" FT /translation="MLDAPEEEPALADDLTGEDEQPPVEFQWPSTLQARATRRGLLLTA FT LGGLLIGGLVTAIPTVGTGSGLLATYIDSNPVPSTGAKSNVAFNRATNGDCLMWPDSTP FT HTAVIVNCADDHRFEVAESIDMRTFPGSEYGPNAAPPSPARIQQISEEQCETAVRRYLG FT TKFDPNSKYTISMLWSGDRAWRQSGERRMLCGLQLPGVNNQQVAFKGKVANIDQSKVWP FT AGTCLSIDLTTNQPIDIPVDCVAPHAMEVTGTVNLADKFPNALPAASEQDTFIKDACTR FT LTDIYLAAIELRTTTLTLIYPTLSLSSWAAGSRKVACSIGATMGNGGWATLVNSAKGPL FT LINNQPPTPPPDIPEERLGMPPIPLHHLQVPNSQSNVPVNPIPPGNQQHRKQQPIVTVP FT QSPASTAPAASVSPAKHLPKARHTRQMSKRRGRPISPHPWAGRASPGGLAE" FT CDS 102122..103375 FT /transl_table=11 FT /gene="serS" FT /gene_synonym="ML0082" FT /product="putative seryl-tRNA synthase" FT /EC_number="6.1.1.11" FT /note="Similar to M. tuberculosis Rv3834c, serS, seryl-tRNA FT synthetase, SW:SYS_MYCTU (P96244) (419 aa); Fasta score FT E(): 0, 85.8% identity in 416 aa overlap. Similar to FT Staphylococcus aureus serS, seryl-tRNA synthetase, FT SW:SYS_STAAU (Y09924) (428 aa); Fasta score E(): 0, 36.8% FT identity in 418 aa overlap. Contains Pfam match to entry FT PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S FT and T). Contains PS00179 Aminoacyl-transfer RNA synthetases FT class-II signature 1." FT /db_xref="GOA:Q9CDC1" FT /db_xref="HSSP:1SER" FT /db_xref="InterPro:IPR015866" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDC1" FT /protein_id="CAC29590.1" FT /translation="MIDLQLLREDPDVVRRSQLSRGEDPALVDALLTADTARRAAISAA FT DSLRAEQKATSKSLGAASAEDRPALLERAKDLAEQVKAAETTQAETAAAFAAAYMAISN FT VVLDGVPTGGKDDYAVLDIVGDPPPLSNPKDHLELGEALGLIDMQRGAKVSGSRFYFLT FT GRGALLQLGLLQLALRLAVENDFIPMIPPVLVRPEVMSGTGFLGAHAEEVYRVDDLYLV FT GTSEVPMAGYHSDEILDLSVGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFV FT YCAPTDAEVEHQRLLGWQREMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWVPTQGSY FT CELTSTSNCTTFQARRLATRYRDASGKPQIVATLNGTLGTTRWLVAILENHQRPDGSVR FT VPPALVPFVGTELLESPR" FT misc_feature 102338..103348 FT /note="Pfam match to entry PF00587 tRNA-synt_2b, tRNA FT synthetase class II (G, H, P, S and T), score 132.30, FT E-value 8.8e-36" FT misc_feature 102881..102955 FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT CDS complement(105732..106191) FT /pseudo FT /transl_table=11 FT /gene="ML0083" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3831 (Best blastx score 151)" FT CDS complement(106286..106599) FT /pseudo FT /transl_table=11 FT /gene="ML0084" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3819 (Best blastx score 138)" FT CDS complement(106635..108159) FT /pseudo FT /transl_table=11 FT /gene="ML0085" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3818 (Best blastx score 275)" FT CDS complement(108258..108991) FT /pseudo FT /transl_table=11 FT /gene="ML0086" FT /product="probable aminoglycoside 3'-phosphotransferase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3817 (Best blastx score 203)" FT CDS 109049..109822 FT /transl_table=11 FT /gene="ML0087" FT /product="putative acyltransferase" FT /note="Similar to M. tuberculosis Rv3816c, probable FT acyltransferase, TR:O07807 (EMBL:AL123456) (259 aa); Fasta FT score E(): 0, 81.5% identity in 254 aa overlap. Also FT similar to the neighbouring putative acyltransferases in M. FT tuberculosis, Rv3815c and Rv3814c. Shows similarity to many FT putative bacterial acyltransferases. Contains Pfam match to FT entry PF01553 Acyltransferase, Acyltransferase." FT /note="Similar to ML0892" FT /db_xref="GOA:Q9CDC0" FT /db_xref="InterPro:IPR002123" FT /db_xref="UniProtKB/TrEMBL:Q9CDC0" FT /protein_id="CAC29595.1" FT /translation="MAVEPLYGTVIQFARLLWLIQGLKVSVRGIENLPASGGAVIAINH FT TSYLDFTFAGLPAYQQGLGRKVRFMAKQEVFDGKITGPIMRRLRHIPVDRQEGAASYEA FT AVRNLKDGELVGVYPEATISRSFEIKECKGGAARMSAEARVPIIPHIVWGSQRIWTKDC FT PKKLLRPKVPILVLVGEPIEPTLGVAQLKALLHFRMQHLLERAQELYGPHPAGEFWVPH FT RLGGGAPSLIKAARLDAEEATERAARRAQRAKVAE" FT misc_feature 109136..109678 FT /note="Pfam match to entry PF01553 Acyltransferase, FT Acyltransferase, score 170.90, E-value 2.1e-47" FT CDS 109842..110234 FT /pseudo FT /transl_table=11 FT /gene="ML0088" FT /product="probable acyltransferase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3815c (Best blastx score 228)" FT CDS 110329..111174 FT /transl_table=11 FT /gene="ML0089" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3813c, conserved FT hypothetical protein, TR:O07810 (EMBL:AL123456) (273 aa); FT Fasta score E(): 0, 80.4% identity in 271 aa overlap. FT Similar to many other bacterial hypothetical proteins. FT Contains Pfam match to entry PF00592 DUF3, Cof family." FT /db_xref="GOA:Q9CDB9" FT /db_xref="InterPro:IPR000150" FT /db_xref="UniProtKB/TrEMBL:Q9CDB9" FT /protein_id="CAC29597.1" FT /translation="MTDTTRPAPTPTQPTLIACDVDGTLLDENETVTARTRAAVRSAVA FT GGAYFVLATGRPPRWVRPVVDALGFPPMAVCANGAVIYDPATDRVVSARTLAVDILGEL FT VEIATRVIPGAGLAVERVGDRAHDSATPQFVSSVGYEHAWLHPDNTEVSIEDLLSVPAI FT KLLIRKSGARSADMAAELAKHVGIAGDITYSTNNGLVEILPLGISKATGVEEVGRPLGI FT ADGNAAAFGDMPNDVPMLLRAGHGVAMGNAHPAVLAAADEITAPNTDDGVARVLERWWS FT " FT misc_feature 110401..111135 FT /note="Pfam match to entry PF00592 DUF3, Cof family, score FT 91.10, E-value 2.2e-23" FT CDS complement(111660..112884) FT /pseudo FT /transl_table=11 FT /gene="csp" FT /gene_synonym="ML0090" FT /product="secreted protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT csp (Best blastx score 228)" FT CDS complement(113153..113863) FT /transl_table=11 FT /gene="ML0091" FT /product="28 KDa antigen precursor" FT /note="Similar to M. tuberculosis Rv3810, erp, pirG, FT exported repetitive protein precursor, SW:ERP_MYCTU FT (Q50793) (284 aa); Fasta score E(): 1.8e-23, 52.7% identity FT in 281 aa overlap. Previously sequenced as SW:28KD_MYCLE FT (P19361) (236 aa); Fasta score E(): 0, 99.6% identity in FT 236 aa overlap. Contains a probable N-terminal signal FT sequence." FT /db_xref="UniProtKB/Swiss-Prot:P19361" FT /protein_id="CAC29599.1" FT /translation="MPNRRRCKLSTAISTVATLAIASPCAYFLVYEPTASAKPAAKHYE FT FKQAASIADLPGEVLDAISQGLSQFGINLPPVPSLTGTDDPGNGLRTPGLTSPDLTNQE FT LGTPVLTAPGTGLTPPVTGSPICTAPDLNLGGTCPSEVPITTPISLDPGTDGTYPILGD FT PSTLGGTSPISTSSGELVNDLLKVANQLGASQVMDLIKGVVMPAVMQGVQNGNVAGDLS FT GSVTPAAISLIPVT" FT RBS complement(113870..113874) FT /note="possible RBS" FT CDS 114130..115371 FT /transl_table=11 FT /gene="glf" FT /gene_synonym="ML0092" FT /product="putative UDP-galactopyranose mutase" FT /note="Similar to M. tuberculosis Rv3809c, glf, FT UDP-galactopyranose mutase, TR:O06934 (EMBL:U96128) (399 FT aa); Fasta score E(): 0, 86.6% identity in 396 aa overlap. FT Similar to e.g. Escherichia coli glf, UDP-galactopyranose FT mutase, SW:GLF_ECOLI (P37747) (367 aa); Fasta score E(): 0, FT 43.1% identity in 378 aa overlap." FT /db_xref="GOA:Q9CDB8" FT /db_xref="HSSP:1I8T" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CDB8" FT /protein_id="CAC29600.1" FT /translation="MTVSFDLFVVGSGFFGLTIAERVATQLGKRVLIVEKRPHIGGNAY FT SEAEPQTGIEVHKYGAHLFHTSSKRVWDYVRQFTEFTDYRHRVFAVHNGQVYQFPMGLG FT LVSQFFGRYFTPDEARQLIAEQASEIDTADAKTLEEKAISLIGRPLYEAFVKGYTAKQW FT QTDPAELPAAVISRLPVRYTFDNRYFSDIYEGLPVDGYTAWCTKMADDDRIEVRFGTDW FT FDVADQLRADSLGAPVVYTGPLDRYFDYAAGRLGWRTLDFEVEVLPIGDFQGTPVMNYS FT DLDVPFTRIHEFRHFHRERHYPIDKTVIMREYSRFAGYDDEPYYPINTEADRAMLAAYR FT AKAKSETASSKVLFGGRLGTYQYLDMHMAIAAALNMYDNILAPHLRDGSPLMEEPAVAA FT AQHAAPAIGREGGA" FT CDS 115371..117302 FT /transl_table=11 FT /gene="ML0093" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3808c, hypothetical FT protein, TR:O53585 (EMBL:AL123456) (637 aa); Fasta score FT E(): 0, 85.4% identity in 643 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CDB7" FT /protein_id="CAC29601.1" FT /translation="MTAVSLLARVILPRPGDPLDVRKLYLVESITNARRAHALSPTTLQ FT IGAESEVSFATYFNAFPASYWRRWTICKSVVLRVEVTGAGRVDVYRTKANGARIFVEGR FT EFAGVEDDASKAQVVELEVGLQPFEDGGWIWFDITAETRVTLCSGGWYATSPAPGRANI FT AVGIPTFNRPADCTNALAELTADPLVDEVIGAVIVPDQGVRKVRDHPDFPEAAARLGDR FT LSIHDQPNLGGSGGYSRVMYEALKNTDCQQILFMDDDIRIEPDSILRVLAMHRFAKSPM FT LVGGQMLSLQEPSHLHIMGEVVNRSNFIWTAAPHAEYDHDFVEYPLNDKEDKSKLLHRR FT IDVDYNGWWTCMIPRQVAEELGQPLPLFIKWDDADYGLRAAEHGYPTVTLPGAAIWHMA FT WSDKDDAIDWQAYFHLRNRLVVAAMHWDGDVTGLVRSHLKATLKHLACLEYSTVAIQNK FT AIDDFLAGPDHIFSILESALPEVHRMRKEYPDAVVLPAATELPPPVHKNKVMKPPENPL FT SIVYRLLRGIFHNLTAADPECHKRPEFNIPTQDARWFRLCTVDGVTVTTADGCGVVYRQ FT RDRAKMFLLLFSSLHRQLQLARRFDELRKIYRDALPVLSSKQKWEMALLPLPDSPTRFP FT AEQEPEHA" FT CDS 117295..117873 FT /transl_table=11 FT /gene="ML0094" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3807c, possible FT membrane protein, TR:O53584 (EMBL:AL123456) (165 aa); Fasta FT score E(): 0, 72.8% identity in 151 aa overlap and to FT Streptomyces coelicolor SC5G8.11, putative integral FT membrane protein, TR:CAB89062 (EMBL:AL353872) (169 aa); FT Fasta score E(): 1.7e-15, 45.1% identity in 153 aa overlap. FT Contains hydrophobic, possible membrane-spanning region. FT Contains Pfam match to entry PF01569 PAP2, PAP2 FT superfamily." FT /db_xref="GOA:Q9CDB6" FT /db_xref="InterPro:IPR016118" FT /db_xref="UniProtKB/TrEMBL:Q9CDB6" FT /protein_id="CAC29602.1" FT /translation="MPEDKAPTGELAAIAAVQSVLVDRPGVLPTARGMSHFGEHSIGWL FT AISLLGAILVPCRRRYWLVAGAGVFAAHVAAVLIKRMVRRIRPNHPAVTVNVGTPSPLS FT FPSAHATSTAAAAILIGRASRLPKGIVAAVLVAPMALSRIVLGVHYPSDVAFGVVLGAA FT VAGTTARFDSRLSRRWTVQHGLSSGSAVK" FT misc_feature 117409..117825 FT /note="Pfam match to entry PF01569 PAP2, PAP2 superfamily, FT score 97.10, E-value 3.4e-25" FT CDS 117870..118778 FT /transl_table=11 FT /gene="ML0095" FT /product="putative integral membrane protein" FT /note="Similar to M. tuberculosis Rv3806c, possible FT integral membrane protein, TR:O53583 (EMBL:AL123456) (302 FT aa); Fasta score E(): 0, 83.8% identity in 302 aa overlap FT and to bacterial putative membrane proteins e.g. FT Streptomyces coelicolor SC5G8.12, putative integral FT membrane protein, TR:CAB89063 (EMBL:AL353872) (322 aa); FT Fasta score E(): 0, 48.6% identity in 290 aa overlap and FT Azorhizobium caulinodans noeC, possible integral membrane FT protein found near nod locus, SW:NOEC_AZOCA (Q43967) (307 FT aa); Fasta score E(): 1.1e-12, 31.4% identity in 191 aa FT overlap. Contains hydrophobic, possible membrane-spanning FT regions." FT /db_xref="GOA:Q9CDB5" FT /db_xref="InterPro:IPR000537" FT /db_xref="UniProtKB/TrEMBL:Q9CDB5" FT /protein_id="CAC29603.1" FT /translation="MSEDVMIGSSGNLVIGVVKAIRPRQWVKNVLVLAAPLAGLGGGMH FT YRYAELLTEVSLAFVVFSLAASSVYLINDVRDIEADQEHPTKRFRPIAAGVVTEWLAYT FT LAVVLGVASLVVAWLMTPNLALVMVIYIGMQLGYCFGLKHQAVVDICIVSSAYLIRAIA FT GGVATNIPLSQWFLLTAAFGSLFMVAGKRYAELQLTERTGAAIRKSLESYTSTYLRFVW FT TLSATAVVMCYGLWAFERDRHSGSWFAVSMVPFTIAILRYAVDVDGGLAGEPEGIALRD FT RVLQLLALTWAGTIGAAVVFG" FT CDS 118819..120768 FT /transl_table=11 FT /gene="ML0096" FT /product="putative membrane protein" FT /note="similar to M. tuberculosis Rv3805c, possible FT membrane protein, TR:O53582 (EMBL:AL123456) (627 aa); Fasta FT score E(): 0, 80.9% identity in 629 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CDB4" FT /protein_id="CAC29604.1" FT /translation="MRRRMVSRQVGWPLFPYHIVVRVSLWASVLLVAALFGWGAWQRRW FT IADDGLIVLRTVRNLLAGNGPVFNQGERVEANTSTVWTYLLYAGSWVGGPMRFEYVALA FT AALVLSVLGMVLLMLGTGRLYAPSLQGRQAIMLPAGALVYVALPPARDFATSGLESGLV FT LTYLGLLWWMMVCWAQPLRNRSQSRRFIGALAFVAGCSVLVRPELALMGGSALIMLMIA FT ARTCWLRALIVVAGGSLPVAYQLFRMGYYGLLVPGTALAKDAAGDKWSQGIIYLSNFNQ FT PYVLWVPLVLLVLLGLLLMLIHRWPSFMHPLETPDSGRVARAVQSPPAVVVFVVFSGLL FT QAFYWIRQGGDFMHGRVLLAPLFCLLAPVVVIPVVISEGADFSRQTGNWLAGVTSLLWL FT GVAGWSLWAANSPGMGDDATNVSYSGIVDERRFYAQATGHAHPLTAADYLGYPRMAAVL FT VALNNTPDGALLLPSGNYIKWDLVPMIQLSPSSPGSPPDSLVSQKPQHTVFFTNLGMLG FT MNVGLDVRVIDQIGLANPLAQHTERLQHGRIGHDKNLFPDWVIADGPWVKWYPGIPGYL FT DQAWIAQAVAALQCSGTQAVLSSVRAPMALHRFISNLLNSFEFTRYRFDRVPLYELVRC FT GLPVPDVLPATPPE" FT RBS 121138..121145 FT /note="possible RBS" FT CDS 121157..122149 FT /transl_table=11 FT /gene="fbpA" FT /gene_synonym="ML0097" FT /product="antigen 85A, mycolytransferase" FT /note="Similar to mycobacterial fbpA, antigen 85-A FT precursors e.g. M. tuberculosis fbpA, antigen 85-A FT precursor, SW:A85A_MYCTU (P17944) (338 aa); Fasta score FT E(): 0, 83.0% identity in 329 aa overlap. Also similar to FT the B- and C- proteins of the mycobacterial antigen 85 FT complexes. Similar to N-terminal region of Corynebacterium FT glutamicum csp1, PS1 protein precursor, SW:CSP1_CORGL FT (Q01377) (657 aa); Fasta score E(): 5.2e-31, 38.6% identity FT in 290 aa overlap. Previously sequenced as SW:A85A_MYCLE FT (Q05861) (330 aa); Fasta score E(): 0, 100.0% identity in FT 330 aa overlap. Contains probable N-terminal signal FT sequence. Contains Pfam match to entry PF00756 Esterase, FT Putative esterase." FT /note="Similar to ML0098, ML2028 and ML2655" FT /db_xref="GOA:Q05861" FT /db_xref="HSSP:1F0N" FT /db_xref="InterPro:IPR000801" FT /db_xref="UniProtKB/Swiss-Prot:Q05861" FT /protein_id="CAC29605.1" FT /translation="MKFVDRFRGAVAGMLRRLVVEAMGVALLSALIGVVGSAPAEAFSR FT PGLPVEYLQVPSPSMGRDIKVQFQNGGANSPALYLLDGLRAQDDFSGWDINTTAFEWYY FT QSGISVVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQYLQSNKQIKPTGSA FT AVGLSMAGLSALTLAIYHPDQFIYVGSMSGLLDPSNAMGPSLIGLAMGDAGGYKAADMW FT GPSTDPAWKRNDPTVNVGTLIANNTRIWMYCGNGKPTELGGNNLPAKLLEGLVRTSNIK FT FQDGYNAGGGHNAVFNFPDSGTHSWEYWGEQLNDMKPDLQQYLGATPGA" FT misc_feature 121241..121903 FT /note="Pfam match to entry PF00756 Esterase, Putative FT esterase, score 381.30, E-value 9.7e-111" FT RBS 122299..122304 FT /note="possible RBS" FT CDS 122310..123215 FT /transl_table=11 FT /gene="fbpC" FT /gene_synonym="ML0098" FT /product="antigen 85C, mycolyltransferase" FT /note="Similar to mycobacterial fbpC, antigen 85-C FT precursors e.g. M. tuberculosis fbpC, antigen 85-C FT precursor, SW:A85C_MYCTU (P17944) (340 aa); Fasta score FT E(): 0, 40.7% identity in 305 aa overlap. Also similar to FT the B- and C- proteins of the mycobacterial antigen 85 FT complexes. Similar to N-terminal region of Corynebacterium FT glutamicum csp1, PS1 protein precursor, SW:CSP1_CORGL FT (Q01377) (657 aa); Fasta score E(): 1.4e-14, 31.5% identity FT in 248 aa overlap. Previously sequenced as MPB51 precursor, FT TR:Q48923 (EMBL:D26486) (299 aa); Fasta score E(): 0, 77.5% FT identity in 302 aa overlap. Contains probable N-terminal FT signal sequence. Contains Pfam match to entry PF00756 FT Esterase, Putative esterase." FT /note="Similar to ML0097, ML2028 and ML2655" FT /db_xref="GOA:Q05868" FT /db_xref="HSSP:1DQZ" FT /db_xref="InterPro:IPR000801" FT /db_xref="UniProtKB/Swiss-Prot:Q05868" FT /protein_id="CAC29606.1" FT /translation="MRGLSAVVRVLCVAALAVGVFAAAVLLAGTAGNAKAAGYESLMVP FT SNAMGRDIPVAFMAGGPHAVYLLDAFNAALDVSNWVTAGNAMTTLGGRGISVVAPAGGA FT YSMYTNWENDGSKQWDTFLSSELPDWLATKRGLAPDGHAAVGASQGGYAALALAAFHPD FT RFGFAGSLSGFVYPSSTNYNGAILAGLQQFGGIDGNGMWGAPQLGRWKWHDPYVHASLL FT AQNNTRVWVYSPMTMGGDIDAMIGQAVASMGSSREFYQQYRSVGGHNGHFDFSGGGDNG FT WGAWAPQLAAMSGDIVGAIR" FT misc_feature 122382..122996 FT /note="Pfam match to entry PF00756 Esterase, Putative FT esterase, score 305.30, E-value 7.3e-88" FT RBS 123358..123363 FT /note="possible RBS" FT CDS 123370..124380 FT /transl_table=11 FT /gene="ML0099" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3802c, hypothetical FT protein, TR:O53581 (EMBL:AL123456) (336 aa); Fasta score FT E(): 0, 75.5% identity in 335 aa overlap." FT /db_xref="GOA:Q9CDB3" FT /db_xref="InterPro:IPR000675" FT /db_xref="UniProtKB/TrEMBL:Q9CDB3" FT /protein_id="CAC29607.1" FT /translation="MVEKVPRKRHRVLAWTAALSMAAVVALAIVAVVILLRSAESPRSS FT LPPGVLPIPSTAPHPRKPRPAFQDVSCPDVQLLVVPGTWESSLQDNPLDPVQFPDALLR FT NSTMTIGQQFPTSRVQTYTIPYTAQFHNPLSGDKQMTYNDSRAEGTRAMVQEMINVNNK FT CPLTSYVLVGFSQGAVIAGDITSDIGNGHGPVDDDLVLGVTLIADGRRQQGVGNDIGPN FT PPGEGAEVTLHEVPVLSGLGMTMTGARPGGFGVLHSRTNEICAPGDLICAAPAEAFSVA FT NLPATLNTLASGAGQPIHAMYATAQFWDLDGAPATVWTLNWVHRLIEGAPHPKHG" FT CDS 124599..126506 FT /transl_table=11 FT /gene="fadD32" FT /gene_synonym="ML0100" FT /product="putative acyl-CoA synthetase" FT /note="Similar to several putative acyl-CoA synthases from FT M. tuberculosis e.g. M. tuberculosis Rv3801c, fadD32, FT putative acyl-CoA synthase, TR:O53580 (EMBL:AL123456) (637 FT aa); Fasta score E(): 0, 93.2% identity in 632 aa overlap. FT Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, FT TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 36.8% FT identity in 581 aa overlap and to domains of polyketide FT synthases e.g. Myxococcus xanthus safB, saframycin Mx1 FT synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta FT score E(): 0, 36.4% identity in 605 aa overlap. Contains FT Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme." FT /note="Similar to ML0132, ML0138, ML1234 and ML2358" FT /db_xref="GOA:Q9CDB2" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q9CDB2" FT /protein_id="CAC29608.1" FT /translation="MTGEGRMAYHNPFIVNGKIRFPPNTNLVRHVEKWAKVRGDKLAYR FT FLDFSTGRDGVARDILWSEFSARNRAVGARLQQVTQPGDRIAILCPQNLDYLISFFGAL FT YSGRIAVPLFDPAEPGHVGRLHAVLDDCTPSTILTTTDSAEGVRKFIRGRFAKERTRVI FT AVDAVPNEVAATWQQPEANEETVAYLQYTSGSTRIPSGVQITHLNLPTNVLQVLNSLQG FT QEGDRGVSWLPFFHDMGLITVLLPSVLGHSFTFMTPAAFVRRPGRWIRELARKPEDTGG FT TFSAAPNFAFEHAAMRGLPRDDELPLDLSNVKGILNGSEPVSPASMRKFFEAFAPYGLK FT QTAVKPSYGLAEATLFVSTTPMDESPTVIHVDRYELNNQRFVEVPADAPNAVAQVSAGK FT VGVSEWAIIVDADTASELPDGQIGEIWLHGNNLGTGYWGKEEESAQTFNNILKSRISES FT RAEGASDDASWVRTGDYGTYFKDHLYIAGRIKDLVIIDGRNHYPQDLEYTAQESTKALR FT VGYVAAFSVPANQLAQVVLEDPHVGLKFDAEDTSEQLVIVGERAAGTHKLDYQPIVDDI FT RAAIAVRHGVAVRDVLLVPAGTIPRTSSGKIGRRACRAAYIDGSLRSGASSPTVFAAEF FT " FT misc_feature 124803..126158 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score -85.00, E-value 1.1e-10" FT CDS 126518..131872 FT /transl_table=11 FT /gene="pks13" FT /gene_synonym="ML0101" FT /product="polyketide synthase" FT /note="Similar to many polyketide synthases from M. FT tuberculosis e.g. ppsA, M. tuberculosis phenolpthiocerol FT synthesis polyketide synthase, SW:PPSA_MYCTU (Q10977) (1876 FT aa); Fasta score E(): 0, 36.1% identity in 1277 aa overlap. FT Similar to many others e.g. Streptomyces noursei nysI, FT nystatin biosynthesis polyketide synthase, TR:AAF71766 FT (EMBL:AF263912) (9477 aa); Fasta score E(): 0, 33.4% FT identity in 1215 aa overlap. Contains Pfam match to entry FT PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains FT Pfam match to entry PF00698 Acyl_transf, Acyl transferase FT domain. Contains Pfam match to entry PF00975 Thioesterase, FT Thioesterase domain. Contains 2 Pfam matches to entry FT PF00550 pp-binding, Phosphopantetheine attachment site. FT Contains PS00606 Beta-ketoacyl synthases active site." FT /note="Similar to ML0135, ML0139, ML1229, ML2353, ML2354, FT ML2355, ML2356, ML2357, and ML2607" FT /db_xref="GOA:Q9CDB1" FT /db_xref="HSSP:1MO2" FT /db_xref="InterPro:IPR018201" FT /db_xref="UniProtKB/TrEMBL:Q9CDB1" FT /protein_id="CAC29609.1" FT /translation="MADVDAPQLNQDPPQLNQDPQANLPAEKTKMRFGDDAERSDEEVR FT RITRITTVPEMRQWLRNWVGKVVGKSPDDIDESAPMVELGLASRDAVAMAADIEDLTGV FT TLSVAVAFQYPTIESLANRIIEGESETIDDDTDAFDWSRTGSAERIDIAVVGLSTRLPG FT DMNSPEETWRALLEGRDAITDLPAGRWSEFLGEPRLAQRIAQARTRGGYLKDIKGFDSD FT FFAVAKTEAENIDPQQRMALELTWEALEHARIPASSLRGEAVGVYIGSSTNDYSFLAVS FT DPTIAHPYAITGTSSSIIANRVSYFYDFRGPSVTIDTACSSSLVAIHQGVQALRNGEAD FT VVVAGGVNALITPMVTLGFDEIGSVLAPDGRIKSFSSDADGYTRSEGGGVLVLKRVNDA FT RRDGDQILAVIAGSAVNHDGRSNGLIAPNQDAQADVLRRAYKDAGIDPRTVDYIEAHGT FT GTVLGDPIEAEALGRVVGRGRPADRPALLGAVKTNVGHLESAAGAASMVKVVLALQHDK FT LPPSINFAGPSPYIDFDAMRLKVIDTATDWPRYGGYALAGVSSFGFGGANAHLVVREVL FT PRDVIEPERQPESPVPAAATTETAMLEGRVLRFDECGEIITDVADFGESEPELPGMTDE FT ALQLKQAALEALAVKQVTAPLIPLVVSSFLTSRKKAAAAELADWMDSPQGRASSLESIG FT RSLSRRNHGRSRAVVLAHYHDEAIEGFRAIAEGKQRPHVFSVDGPVTNGPVWVFAGFGA FT QHREMGKSLYLRNQVFAEWIEKVDALVQDERGYSVLELILDDAQDYGIETTQVTIFAIQ FT IALGELLKHHGAKPAAVVGQSLGEAACAYFVGGLSLRDATRAICSRSHLMGEGEAMLFG FT EYIRLMALVEYSADEIKTVFSDFPDLEVCVYAAPTQIVIGGPPEQVDAIIARAKAEGKF FT ARKFATKGASHTQQMDPLLGELAAELQGIKPMSPTAGIYSTVHEGSYIKPGSDPIHDVD FT YWKKGLRHSVHFTQGIRNAVDNGHTTFLELAPNAVALMQVGLTTAAVGLHDAQLIPTLS FT RNQDEVESMISTMAQLYVYGHDLDIWTLFSRAVGPEDYADIPPTRFKRKEHWLDVHFAG FT DGSVSMPGNHVALPDSRHVWEFAPRDKTDLAALVRAAVSQVLPGAHLTAAEQRAMPGAG FT ARLVTMLTRHPGGASVQVHARIDESFTLVYDALVARGGQESVLPTAVGAGTAIASITVP FT ADAVTVAAEESDAEILSDSLTNRYLPSDMGKWSPDSGETIGHRLSTIVAAAMGYEPEDL FT PWEVPLVELGLDSLMAVRIKNRVEYDFDLPPIQLQAVRDANLYNVEKLIEYAIKHRDDV FT EQLHEYQKTQTAAAIAKAQMELLSGVSPVTLPASEAPIPPPPTDPTDPPSNGVQPNLVA FT AAEALTSEAVAKVLNSDVPPRDAAERVTFAAWAIVTGKSPGGIFDTLPKLDGDTAAKMA FT QRLSERAEGTITAEDVLTSENIEALAGKVRNYLEAGQIDGFVRAIRPRAEDSAEGPAGE FT SRVPVFVFHPAGGSTVVYEPLLKRLPADTPMYGFERVEGSIEERVAVYVPKLIEMQGDG FT PYILAGWSLGGVLAYACAIGLRSAGKEVAWVGLIDAVRAGEEIPQTKEEIRKRWDRYAR FT FAERTFNVTVPEIPYEQLEELDDEGQVRFVLDVVSQSGVQIPAGIIDHQRTSYLDNRAI FT DTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRKPDGGWGEYVSDLEVVPIGGEHIQA FT IDEPIIAKVGEHMSQALNKIEAEQKAPK" FT repeat_region 126536..126556 FT /note="21 bp direct repeat, CCCCAATTGAACCAGGACCCT" FT repeat_region 126557..126577 FT /note="21 bp direct repeat, CCCCAATTGAACCAGGACCCT" FT misc_feature 126689..126889 FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 55.80, E-value FT 8.4e-14" FT misc_feature 126971..128248 FT /note="Pfam match to entry PF00109 ketoacyl-synt, FT Beta-ketoacyl synthase, score 596.90, E-value 1.3e-175" FT misc_feature 127448..127498 FT /note="PS00606 Beta-ketoacyl synthases active site" FT repeat_region 128108..128677 FT /note="570 bp repeat, 100% identitical to region FT 3112112..3112681, occupied by pseudogene ML2067" FT misc_feature 128747..129730 FT /note="Pfam match to entry PF00698 Acyl_transf, Acyl FT transferase domain, score 213.30, E-value 3.7e-60" FT misc_feature 130316..130456 FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 23.60, E-value FT 6.6e-05" FT misc_feature 131084..131836 FT /note="Pfam match to entry PF00975 Thioesterase, FT Thioesterase domain, score 40.90, E-value 2.8e-08" FT CDS 131869..133422 FT /transl_table=11 FT /gene="accD4" FT /gene_synonym="ML0102" FT /product="putative acyl CoA carboxylase [beta] subunit" FT /note="Similar to many acyl-CoA carboxylase subunits e.g. FT M. tuberculosis pccB, acetyl/propionyl-CoA carboxylase FT [beta] subunit, TR:O53578 (EMBL:AL123456) (518 aa); Fasta FT score E(): 0, 91.2% identity in 512 aa overlap and FT Streptomyces coelicolor pccB, propionyl-CoA carboxylase FT complex B subunit, TR:Q9X4K7 (EMBL:AF113605) (530 aa); FT Fasta score E(): 0, 48.2% identity in 521 aa overlap. FT Contains Pfam match to entry PF01039 Carboxyl_trans, FT Carboxyl transferase domain." FT /note="Similar to ML0731 and ML1657" FT /db_xref="GOA:Q9CDB0" FT /db_xref="HSSP:1ON3" FT /db_xref="InterPro:IPR011762" FT /db_xref="UniProtKB/TrEMBL:Q9CDB0" FT /protein_id="CAC29610.1" FT /translation="MIMKSTAEKLAELRVRLELANEPGGEKAAAKRDKKNIPSARARIY FT ALVDPGTFLEIGALTRTPGDPNALYGDGVVTGHGLINGRQVGVFSHDQTVFGGTVGEMF FT GRKVARLMEWCAMAGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGIVPQISIV FT LGKCAGGAVYSPIQTDLVVAVRGQGYMFVTGPDVIKDVTGEEVSLDELGGVDSQAKYGN FT IHQVVESEAAAFGYVRDFLSFLPPNCFDKAPIVNPGLEPEIMAHDLELDSIVPDSDNTA FT YDMREVLLRIFDDGHFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHLSGAIDNEASD FT KAARFIRFCDAFNIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITI FT RKSYGGAYAVMGSKQLAADLNFAWPTARIAVIGADGAAQLLMKRFPDPSSPDVQAIRKT FT FVDNYNLNMAIPWIAAERGFIDAVVEPHQTRLLLRKSLHLLRDKQQWWRVGRKHGLIPL FT " FT misc_feature 131914..133419 FT /note="Pfam match to entry PF01039 Carboxyl_trans, Carboxyl FT transferase domain, score 544.70, E-value 6.3e-160" FT CDS complement(133849..135036) FT /pseudo FT /transl_table=11 FT /gene="fadE35" FT /gene_synonym="ML0103" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE35 (Best blastx score 159)" FT CDS complement(136573..139824) FT /transl_table=11 FT /gene="embB" FT /gene_synonym="ML0104" FT /product="putative arabinosyl transferase" FT /note="Similar to M. tuberculosis embB, probable arabinosyl FT transferase, TR:P72030 (EMBL:AL123456) (1098 aa); Fasta FT score E(): 0, 78.0% identity in 1101 aa overlap and to FT other putative mycobacterial arabinosyltransferases. FT Involved in resistance to ethambutol in M. tuberculosis. FT Contains hydrophobic, possible membrane-spanning regions." FT /note="Similar to ML0105 and ML0106" FT /db_xref="GOA:Q9CDA9" FT /db_xref="InterPro:IPR007680" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDA9" FT /protein_id="CAC29612.1" FT /translation="MSVIYRAHRVAIANRTASRNVRVARWVAAIAGLIGFVSSVVTPLL FT PVVQTTATLNWPQNGQLNSVTAPLISLTPVDITATVPCAVVAALPPSGGVVLGTAPKQG FT KDANLNALFIDVNSQRVDVTDRNVVILSVPRNQVAGDAGAPGCSSIEVTSTHAGTFATF FT VGVTDSAGNPLRGGFPDPNLRPQIVGVFTDLTGGAPSGLRLSATIDTRFSSTPTTLKRF FT AMMLAIITTVGALVALWRLDQLDGRRMRRLIPARWSMFTLVDVAVIFGFLLWHVIGANS FT SDDGYQMQMARTADHSGYMANYFRWFGSPEDPFGWYYNLLALMIHVSDASMWIRLPDLI FT CGVACWLLLSREVLPRLGPAIVGFKPALWAAGLVLLAAWMPFNNGLRPEGQIALGALIT FT YVLIERAITYGRMTPVALATLTAAFTIGIQPTGLIAVAALLAGGRPMLYILVRRHRAVG FT AWPLVAPLLAAGTVVLTVVFAEQTLSTVLEATKVRTAIGPAQAWYTENLRYYYLILPTV FT DGSLSRRFGFLITALCLFTAVLITLRRKQIPGVARGPAWRLIGTILGTMFFLTFAPTKW FT VHHFGLFAALGAAVAALTTVLVSHEVLRWSRNRMAFLAALLFVMTLCFATTNGWWYVSS FT YGVPFNSAMPRIDGITFSTIFFILFAIVALYAYYLHFTNTGHGEGRLIRTLTVSFWAPI FT PFAAGLMTLVFIGSMVAGIVRQYPTYSNGWANIRALTGGCGLADDVLVEPDSNAGYMTA FT LPSNYGPLGPLGGVNAIGFTANGVPEHTVAEAIRITPNQPGTDYDWEAPTKLKAPGING FT SVVPLPYGLNPNKVPIAGTYTTGAQQQSRLTSAWYQLPKPDDRHPLVVVTAAGKITGNS FT VLHGHTYGQTVVLEYGDPGPNGGLVPAGRLVPDDLYGEQPKAWRNLRFARSQMPFDAVA FT VRVVAENLSLTPEDWIAVTPPRVPELRSLQEYVGSSQPVLLDWEVGLAFPCQQPMLHAN FT GVTDIPKFRITPDYSAKKIDTDTWEDGANGGLLGITDLLLRAHVMSTYLARDWGRDWGS FT LRKFDPLVDTHPAQLDLDTATRSGWWSPGKIRIKP" FT CDS complement(139821..143156) FT /transl_table=11 FT /gene="embA" FT /gene_synonym="ML0105" FT /product="putative arabinosyl transferase" FT /note="Similar to M. tuberculosis embA, probable arabinosyl FT transferase, TR:Q50394 (EMBL:AL123456) (1092 aa); Fasta FT score E(): 0, 64.2% identity in 1108 aa overlap and to FT other putative mycobacterial arabinosyltransferases. FT Involved in resistance to ethambutol in M. tuberculosis. FT Contains hydrophobic, possible membrane-spanning regions." FT /note="Similar to ML0104 and ML0106" FT /db_xref="GOA:Q9CDA8" FT /db_xref="InterPro:IPR007680" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDA8" FT /protein_id="CAC29613.1" FT /translation="MPHDGHEPPQRIIRLIAVGAGITGLLLCAVVPLLPVKQTTATIRW FT PQSATRDGWVTQITAPLVSGTPRALDISIPCSAMATLPDSVGLVVSTLPSGGVDTGKSG FT LFVRANKNAVVVAFRDSVAAVAPRPAVAAGNCSVLHIWANTRGAGANFVGIPGAAGILT FT AEKKPQVGGIFTDLKVPVQPGLSAHIDIDTRFITAPTAIKKIAVGVGAAAVLIAILALS FT ALDRRNRNGHRLINWRVSMAWLAQWRVILATPPRAGGASRIADGGVLATLLLWHIIGAT FT SSDDGYNLTVARVSSEAGYLANYYRYFGATEAPFDWYFTVLAKLASVSTAGVWMRIPAT FT LAGIACWLIINHWVLRRLGPGTGGLSTNRVAVLTAGAMFLAAWLPFNNGLRPEPLIALG FT VLFTWVLVERAIALRRLASAATAAVVAILTATLAPQGLIAIAALLTGARAITQTIRRRR FT TTDGLLAPLLVLAASLSLITLVVFHSQTLATVGESARIKYKVGPTIACYQDFLRYYFLT FT VESNADGSMTRRFPVLVLLLCMFGVLVVLLRRSRVPGLASGPTWRLIGTTATSLLLLTF FT TPTKWAIQFGALAGLTGTFGAIAAFAFARISLHTRRNLTVYITALLFVLAWATAGINGW FT FGVSNYGVPWFDIQPVIAGHPVTSIFLTLSILTGLLAGGQHFRLDYAKHTEVKDTRRNR FT FLATTPLVVVATTMVLCEVGSLAKGAVARYPLYTTAKANLAALRSGLAPSVCAMADDVL FT TEPDPNAGMLQPVPGQIFGPTGPLGGMNPIGFKPEGVNDDLKSDPVVSKPGLVNSDASP FT NKPNVTFSDSAGTAGGKGPVGVNGSHVALPFGLDPDRTPVMGSYGENTLAASATSAWYQ FT LPLHWKESIADRPLVVVSAAGAIWSYKEDGNFIYGQSLKLQWGVTRPDGIIQPLAQVMP FT IDIGPQPAWRNLRFPLTWAPPEANVARVVAYDPNLSPDQWLAFTPPRVPVLQTLQQLLG FT SQTPVLMDIATAANFPCQRPFSEHLGIAELPQYRILPDHKQTAASSNLWQSSEAGGPFL FT FLQALLRTSTISTYLRDDWYRDWGSVEQYYRLVPADQAPEAVVKQGMITVPGWIRRGPI FT RALP" FT CDS complement(144115..147327) FT /transl_table=11 FT /gene="embC" FT /gene_synonym="ML0106" FT /product="putative arabinosyl transferase" FT /note="Similar to M. tuberculosis embC, probable arabinosyl FT transferase, TR:P72059 (EMBL:AL123456) (1094 aa); Fasta FT score E(): 0, 82.8% identity in 1075 aa overlap and to FT other putative mycobacterial arabinosyltransferases. FT Involved in resistance to ethambutol in M. tuberculosis. FT Contains hydrophobic, possible membrane-spanning regions." FT /note="Similar to ML0104 and ML0105" FT /db_xref="GOA:Q9CDA7" FT /db_xref="InterPro:IPR007680" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDA7" FT /protein_id="CAC29614.1" FT /translation="MSGAGANYWIARLLAVIAGLLGALLAMATPFLPVNQNTAQLNWPQ FT NSTFESVEAPLIGYVATGLNVTVPCAAAAGLTGPQSAGQTVLLSTVPKQAPKAVDRGLL FT IQRANDDLVLVVRNVPVVSAPMSQVLSPACQRLTFAAYFDKITAEFVGLTYGPNAEHPG FT VPLRGERSGYDFRPQIVGVFTDLSGPIPTGLNFSATIDTRYSSSPTLLKTIAMILGVVL FT TIVALVALHLLDTADGTQHRRLLPSRWWSIGCLDGLVITILAWWHFVGANTSDDGYILT FT MARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVTTTSAWMRVPTLAMALTCWWL FT ISREVIPRLGHAAKASRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAV FT ATSRLLPVAVACIVGALTLFSGPTGIASIGALLVAVGPLLTILQRRSKQFGAVPLVAPI FT LAASTVTAILIFRDQTFAGESQASLLKRAVGPSLKWFDEHIRYERLFMASPDGSVARRF FT AVLALLVALSVAVAMSLRKGRIPGLAAGPSRRIIGITVTSFLAMMFTPTKWTHHFGVFA FT GLAGSLGALAAVAVASAALRSRRNRTVFAAVVLFVVALSFASVNGWWYVSNFGVPWSNS FT FPKLRWSLTTALLELTVIVLLLAAWFHFVATTNGSAKTRFGVRIDRIVQSPIAIATWSL FT VIFEVASLTMAMIGQYPAWTVGKSNLQALTGQTCGLAEEVLVEQDPNAGMLLPVSTPVA FT DALGSSLAEAFTANGIPADVSADPVMEPPGDRSFVKENGMTTGGEAGNEGGTNATPGIN FT GSRAQLPYNLDPARTPVLGSWQSGIQVVARLRSGWYRLPARDKAGPLLVVSAAGRFDHH FT EVKLQWATDSGAASGQPGGAFQFSDVGASPAWRNLRLPLSAIPSMATQIRLVADDEDLA FT PQHWIALTPPRIPQLRTLQDVVGYQDPVFLDWLVGLAFPCQRPFDHQYGVDETPKWRIL FT PDRFGAEANSPVMDNNGGGPLGVTELLLKATTVASYLKDDWSRDWGALQRLTPYYPNAQ FT PARLSLGTTTRSGLWNPAPLRH" FT CDS complement(147460..149358) FT /transl_table=11 FT /gene="ML0107" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3792, unknown membrane FT protein, TR:P72058 (EMBL:AL123456) (643 aa); Fasta score FT E(): 0, 77.5% identity in 631 aa overlap and to the FT C-terminal half of Mycobacterium smegmatis ORF3, FT hypothetical membrane protein, TR:O05765 (EMBL:U46844) (603 FT aa); Fasta score E(): 0, 67.8% identity in 267 aa overlap. FT Contains hydrophobic, possible membrane-spanning regions." FT /db_xref="GOA:Q9CDA6" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDA6" FT /protein_id="CAC29615.1" FT /translation="MRNALASFGQIVLAAVVASGVAAVSLIAIARVHWPAFPSSNQLHA FT LTTVGQVGCLTGLLAVGGVWQAGRFRRLAQLGGLVFVSAFTVVTLGMPLGATKLYLFGI FT SVDQQFRTEYLTRLTDSAALQDMTYLGLPPFYPPGWFWIGGRVAALTGTPAWEIFKPWA FT ITSITIAVAITLVLWWQMIRFEYALLVTIATAAVTLVYSSPEPYAAMITVLLPPALVLT FT WSGLRAAEREADRTLGNKRGWATVVGAGIFLGFAATWYTLLLAYTAFTVVLMTLLLATA FT LCRRAGFRATFDPLRRLAGIVVIAAAIGAITWLPFLARAAHDPVSDTGSAQHYLPADGA FT ELAFPMLQFSLLGMICMLGTLWLIVRTSSSVRASALMISVLAVYLWSLLSILTTLARTT FT LLSFRLQPTLTVLLVTAGVFGFIETAQSLAKHNRAVLSVASAIGLAGAIAFSQDIPNVL FT RPDLTIAYTDTDGHGQRGDRRPPGSEKYYWAIDEAVLHITGKPRDQTVVLTADYSFLAY FT YPYWGFQGLTSHYANPLAQFDLRAAQIQQWSRLTTASELIHALDTLPWPPPTVFVMRHG FT AGNTYTLRLAKNVYPNQPNVRRYTVDLPAALFADQRFAVQDIGPFVLAIRKPMGNA" FT CDS complement(149361..150125) FT /transl_table=11 FT /gene="ML0108" FT /product="putative oxidoreductase" FT /note="Similar To M. tuberculosis Rv3791, putative FT oxidoreductase, SW:Y1J1_MYCTU (P72057) (254 aa); Fasta FT score E(): 0, 89.0% identity in 254 aa overlap and to other FT putative oxidoreductases from the same organism. Shows FT weaker similarity to Alcaligenes eutrophus phbB, FT acetoacetyl-CoA reductase, SW:PHBB_ALCEU (P14697) (246 aa); FT Fasta score E(): 3e-09, 28.3% identity in 191 aa overlap. FT Contains Pfam match to entry PF00106 adh_short, short chain FT dehydrogenase. Contains PS00061 Short-chain FT dehydrogenases/reductases family signature." FT /note="Shows weak similarity to ML0429 and to the FT C-terminal half of ML2565" FT /db_xref="GOA:Q9CDA5" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CDA5" FT /protein_id="CAC29616.1" FT /translation="MVLDAVGHPQTVLLLGGTSEIGLAICKRYLRNAPARIVLAAMPDD FT PNREDAVAQMTAVGARSVELIDFEALDTDSHPRMIEQAFTGGDVDVAIVAFGLLGDAEE FT LWQNQSKAVQIAEINYTAAVSVGVLLGEKMRAQGFGQIIVMSSAAGERVRRSNFVYGST FT KAGLDGFYLGLSEALHEYGVHVLVIRPGQVRTRMSAHVKEAPLTVNKEYVADLAVTAAA FT KGKELVWAPATFRYVMMVLRHIPRSIFRKLPI" FT misc_feature complement(149538..150098) FT /note="Pfam match to entry PF00106 adh_short, short chain FT dehydrogenase, score 83.50, E-value 4.2e-21" FT misc_feature complement(149601..149687) FT /note="PS00061 Short-chain dehydrogenases/reductases family FT signature" FT CDS complement(150128..151510) FT /transl_table=11 FT /gene="ML0109" FT /product="putative FAD-linked oxidoreductase" FT /note="Similar to M. tuberculosis Rv3790, putative FT oxidoreductase, TR:P72056 (EMBL:AL123456) (461 aa); Fasta FT score E(): 0, 86.6% identity in 461 aa overlap. Also FT similar to many bacterial putative oxidoreductases. FT Contains Pfam match to entry PF01565 FAD_binding_4, FAD FT binding domain." FT /db_xref="GOA:Q9CDA4" FT /db_xref="InterPro:IPR006094" FT /db_xref="UniProtKB/TrEMBL:Q9CDA4" FT /protein_id="CAC29617.1" FT /translation="MLNMGVSTTATRLTGWGRTAPSVANVLSTPDAELISKVVARVADA FT DGRGVIARGLGRSYGDNAQNGGGLVIDMTPLNTIHCINTDTKLADVDAGVNLNKLMKAA FT LPFGLWIPVLPGTRQVTIGGAIACDIHGKNHHSAGSFGNYVRSMDLLTASGEVRRLTPT FT GKDSELFWATVGGNGLTGIIMRATIEMMPTETAYFIADGDITGSLDETIALHSDGSEAD FT YTYSSAWFDAISASPKLGRAAVSRGCLARLDQLPAKLRRNPLKFHAPQLLTLPDVFPNG FT LANKYTFMPIGELWYRKSGTYRGKIQNLTQFYHPLDMFGEWNRAYGAAGFLQYQFVIPT FT EAVDKVKRIIGDMQGSGHYSFLNVFKLFGPGNQAPLSFPIPGWNICVDFPIKSGLNEFV FT NKLDRRVMELGGRLYTAKDSRTTADTFHAMYPRIDEWIAVRRKVDPLRVFSSDMARRLE FT LL" FT RBS complement(150137..150140) FT /note="possible RBS" FT misc_feature complement(150956..151489) FT /note="Pfam match to entry PF01565 FAD_binding_4, FAD FT binding domain, score -2.30, E-value 4.3e-06" FT CDS complement(151578..151949) FT /transl_table=11 FT /gene="ML0110" FT /product="possible membrane protein" FT /note="Similar to M. tuberculosis Rv3789, hypothetical FT protein, SW:Y1I9_MYCTU (P72055) (121 aa); Fasta score E(): FT 0, 73.0% identity in 122 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions." FT /db_xref="GOA:Q9CDA3" FT /db_xref="InterPro:IPR007267" FT /db_xref="UniProtKB/Swiss-Prot:Q9CDA3" FT /protein_id="CAC29618.1" FT /translation="MLRFIVTGSLATAVDFSVYVTLYRGGGLQVDLAKFTSVVIGTITS FT YMINRRWTFQMSPSTTRFAAVMALYGITFAVQMGLNHLCLFLFHYQEPWAIPIAFVIAQ FT GLATVINFIVQRVVIFRIR" FT RBS complement(151953..151956) FT /note="possible RBS" FT CDS complement(152204..152371) FT /pseudo FT /transl_table=11 FT /gene="ML0111" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3788 (Best blastx score 157)" FT CDS complement(152783..153613) FT /transl_table=11 FT /gene="ML0112" FT /product="putative ABC transporter component" FT /note="Similar to M. tuberculosis Rv3783, integral membrane FT protein, TR:P72049 (EMBL:AL123456) (280 aa); Fasta score FT E(): 0, 84.3% identity in 280 aa overlap. Similar to FT Yersinia enterocolitica rfbD, O-antigen export system FT permease protein, SW:RFBD_YEREN (Z18920) (259 aa); Fasta FT score E(): 2.9e-32, 28.2% identity in 259 aa overlap and to FT other membrane proteins involved in lipopolysaccharide FT transport. Contains Pfam match to entry PF01061 FT ABC2_membrane, ABC-2 type transporter." FT /db_xref="GOA:Q9CDA2" FT /db_xref="InterPro:IPR013525" FT /db_xref="UniProtKB/TrEMBL:Q9CDA2" FT /protein_id="CAC29620.1" FT /translation="MTFVDAAAQSRTLARARSDLIEGLHRHELWLHLGWQDIKQRYRRS FT VLGPFWITIATGTTSIAMGGLYSKLFHLDLSVHLPYVTLGLIIWNLINAAILEGAEVFV FT ANEGLIKQLPTPLSVHVYRLVWRQTILFTHNIIIYLVVGILFPKPWSWADLSVFPALAL FT VILNSVWVSLCFGILATRYRDIGPLLFSVVQLLFFITPIIWNDDALRQQGEGRWSSIVE FT LNPLLHYLDIVRAPLLGAHQELRHWAVVVTLTAAGWLLAAFAMRQYRARVPYWV" FT misc_feature complement(152795..153556) FT /note="Pfam match to entry PF01061 ABC2_membrane, ABC-2 FT type transporter, score 276.20, E-value 4.3e-79" FT RBS complement(153624..153629) FT /note="possible RBS" FT CDS complement(153663..154514) FT /transl_table=11 FT /gene="rfbE" FT /gene_synonym="ML0113" FT /product="putative glycosyl transferase" FT /note="Similar to M. tuberculosis Rv3782, putative glycosyl FT transferase, TR:P72048. Shows very weak similarity to FT proteins involved in lipopolysaccharide biosynthesis." FT /db_xref="GOA:Q9CDA1" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q9CDA1" FT /protein_id="CAC29621.1" FT /translation="MLSTQTRLPDHLIVVDNDGAEHSRVRDLVDGQPIPTTYLGSRKNL FT GGAGGFALGMLHALTLGADWVWLADDDGIPQDTRMLATLLACADKYGLAEVSPMVCSLD FT DPELLAFPLRRGLGWHRRASELRTKEGQDLLRGIASLFNGALFRASTLDSIGVPDMRLF FT IRGDEVELHRRLARSGLPFGTCLETIYLHPCGSDEFRPILGGRMHTQYPDDPIKRFFTY FT RNRGYLMAQPGLRKLVAQEWFRFSWFFLVIRRDPKGLREWIRLHRLGRRENFGKPDMRG FT SS" FT CDS complement(154576..155394) FT /transl_table=11 FT /gene="ML0114" FT /product="putative ABC transporter ATP-binding component" FT /note="Similar to M. tuberculosis Rv3781, putative ABC FT transporter component, TR:P72047 (EMBL:AL123456) (273 aa); FT Fasta score E(): 0, 91.4% identity in 267 aa overlap. FT Similar to Yersinia enterocolitica rfbE, O-antigen export FT system ATP-binding protein, SW:RFBE_YEREN (Q56903) (239 FT aa); Fasta score E(): 0, 46.9% identity in 224 aa overlap FT and to other proteins involved in lipopolysaccharide FT transport. Contains Pfam match to entry PF00005 ABC_tran, FT ABC transporter. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop)." FT /db_xref="GOA:Q9CDA0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q9CDA0" FT /protein_id="CAC29622.1" FT /translation="MVEGPHIETNNAWVEFPIFDAKARSLKKAVLGKAGGTIGRNNSNV FT VVIEALRDITMSLSVGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGWAKVTGRVAPVFDL FT GIGMDPEISGYENIIIRGLFLGQTRKQMLGKVDEIAEFTELGDYLSMPLRTYSTGMRVR FT LAMGVVTSIDPEILLLDEGIGSVDTDFLKKAQSRLQSLVERSGILVFASHSNEFLARLC FT KTAMWIDHGVIELSGGIEDVVRAYEGEDAARHVREVIAETASAQNASGDE" FT misc_feature complement(154702..155214) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 118.80, E-value 1e-31" FT misc_feature complement(155170..155193) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(155413..155937) FT /transl_table=11 FT /gene="ML0115" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3780, hypothetical FT protein, SW:Y1I0_MYCTU (P72046) (178 aa); Fasta score E(): FT 0, 82.9% identity in 170 aa overlap and to Streptomyces FT coelicolor SCGD3.23C, hypothetical protein, TR:Q9XA56 FT (EMBL:AL096822) (179 aa); Fasta score E(): 0, 65.7% FT identity in 178 aa overlap." FT /db_xref="InterPro:IPR019695" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD99" FT /protein_id="CAC29623.1" FT /translation="MNNDNDDSIEIIGGVDPRTMATRGEDESRDSDEPSLTDLVEQPAK FT VMRIGTMIKQLLEEVRAAPLDEASRNQLREIHATSIRELEDGLAPELREELDRLTLPFN FT ESTAPSNAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMRHSALPPGMGKPG FT QAGGQGTGQYL" FT RBS complement(155949..155954) FT /note="possible RBS" FT CDS complement(155965..157929) FT /transl_table=11 FT /gene="ML0116" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3779, unknown membrane FT protein, TR:P72045 (EMBL:AL123456) (666 aa); Fasta score FT E(): 0, 66.5% identity in 666 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CD98" FT /protein_id="CAC29624.1" FT /translation="MGLCCGTLIALFLLIVPETIVARFAALTWPIAIAVSPALTYGVIA FT LVIIPFGAVGIPWNSWTALAALVAVSMLMIAFRLLLVRYRDTAAETRGISGWPAVTVAV FT GVLLGALLIGWAAYRGLLHWQSIPSTWDAVWHANTVRFILDTGQASPTHMGELRNVETH FT SVLYYPSVLHALAGVYCQLTGAAPTTGYTVSSLAVAVWLFPVSAATLTWHLLRPVTTQK FT RAAGASATAAALSAAFTSVPYVEFGVAAMPNLAAYGVAVPTMVLITSTLRHRDRIPVAI FT LALVGTFSVHLTGGIVVSLFLLGWWLMNALLHPVRSRAADARTLAAVVMPTALILAPQF FT IAVLNQADIIAGHSFPSFKSVKQGVIDALLLHTRHLNDFPIQYGLVVLAAIGMAILLYQ FT KIWWPSIAWLVLTVATVYSAAPFRGPIGSAIESFSQFFYNDPRRLSAVVTMLLTPMAGI FT ALFAGVLLLVVGARRVTARFTALPRPVWTTATVVLLVAATVLTAWHYLFRHLVLFGDKY FT DSVMVNQKDLDAMSYLATLPGAHNTIIGNSNTDGSSWMYAVADLHPLWTHYDFPQQTGP FT GYFRYAFWAYARTGNPWVVEAVRVFNIRYILTTSPTVQGFAIPDGLVSLEESKSWTKIY FT DNGAARIFEWSGNATATRA" FT RBS 158044..158050 FT /note="possible RBS" FT CDS 158056..159252 FT /transl_table=11 FT /gene="ML0117" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3778c, conserved FT hypothetical protein, TR:P72044 (EMBL:AL123456) (398 aa); FT Fasta score E(): 0, 83.4% identity in 398 aa overlap. Also FT similar to many bacterial hypothetical proteins." FT /note="Similar to ML0596 and to the C-terminal half of FT ML0842" FT /db_xref="GOA:Q9CD97" FT /db_xref="InterPro:IPR015421" FT /db_xref="UniProtKB/TrEMBL:Q9CD97" FT /protein_id="CAC29625.1" FT /translation="MAYDAARVRGLHPSLGDGWVHFDAPAGMLIPDSVATTVSTAFRRS FT SSTTSGAHPSAQRSAAVLAAARASVADLFGADPAGVVLAADRAVLLSSLAAASSSCAGL FT GYEVIVSRLDDEVNIAPWLRAAHRHGAKVKWAEVDIETGELPTWQWESLIGESTRLVAV FT TSASGTLGTVTDLRAMTKLVHDVGGLVVVDHSAASPYRLLDLNETEVDVVAVNAHAWGG FT PPIGAVVFRDPGLIDTFTLASTDPHAAGPARLEVGLHQFGLLAGVVDSIEYLAALDESA FT RGSRRERLSVSMQSAGLYLNRIFDYLMMSLRSLSLVMVIGRPEVRIPVVSFVHQGVPAD FT MVVQRLADNGILAICDPRSRVLDVLGVNDIGGAVTVGLAHYSTTVEVDQLVRTLASLG" FT CDS complement(159249..160259) FT /transl_table=11 FT /gene="ML0118" FT /product="putative oxidireductase" FT /note="Similar to M. tuberculosis Rv3777, putative FT oxidireductase, TR:P72043. Similar to many oxidoreductases FT from both bacteria and higher organisms e.g. Mus musculus FT cryZ, quinone oxidoreductase, SW:QOR_MOUSE (P47199) (331 FT aa); Fasta score E(): 5.5e-21, 31.0% identity in 306 aa FT overlap. Contains Pfam match to entry PF00107 adh_zinc, FT Zinc-binding dehydrogenases." FT /note="Similar to domains of polyketide synthases ML0135, FT ML0139, ML1229 and ML2355" FT /db_xref="GOA:Q9CD96" FT /db_xref="HSSP:1IYZ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CD96" FT /protein_id="CAC29626.1" FT /translation="MHAIVAESANQMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVA FT GKYPHPPGASAIIGMEVAGVVAAVSSGVTEWSVGQEVCALLAGGGYAEYVAVPASQVMP FT IPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLLLHGGTSGIGSHGIQVARALGAK FT VAVTAGSEEKLEFCRALGAQITINYRDEDFVARLQQQNGGADVILDIMGAAYLDRNIDA FT LAIDGQLIVIGLQGGVKGELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASI FT WPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGTETLLSRHH" FT misc_feature complement(159294..160232) FT /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding FT dehydrogenases, score 48.50, E-value 2.4e-12" FT tRNA 160312..160401 FT /gene="serU" FT /note="tRNA Ser anticodon TGA, Cove score 59.58" FT CDS complement(160495..161730) FT /transl_table=11 FT /gene="lipE" FT /gene_synonym="ML0119" FT /product="probable hydrolase" FT /note="Similar to M. tuberculosis Rv3775, probable FT hydrolase, TR:P72041 (EMBL:AL123456) (415 aa); Fasta score FT E(): 0, 84.7% identity in 406 aa overlap. Similar to FT bacterial esterases e.g. Streptomyces chrysomallus estA, FT esterase A, TR:O87861 (EMBL:Z15137) (389 aa); Fasta score FT E(): 2.6e-18, 29.9% identity in 348 aa overlap." FT /db_xref="GOA:Q9CD95" FT /db_xref="InterPro:IPR001466" FT /db_xref="UniProtKB/TrEMBL:Q9CD95" FT /protein_id="CAC29627.1" FT /translation="MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATRHWYQA FT GMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAKAITAT FT VVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRHVLTHSAGVPFPTGPRPDVTRADD FT HAYAQQKLSELRPFYRPGLVHIYHALTWGPLMREIIWTATGKEIRDILAAEILDPLGFR FT WTNFGVAEEDVPLVALSHATGRPLPPIIAAIFRKAIGGTVHEVIPYTNTPPFLTTIVPS FT SNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGAVAECRRLRPDFVVGLMPARWGT FT GFILGTNKFGPFGRNAPAAFGHLGLVNIAIWADPQRSMAAGLISSGKPGQDPNAGRYGA FT LMNTITAEIPVH" FT RBS complement(161739..161742) FT /note="possible RBS" FT CDS complement(161741..162577) FT /transl_table=11 FT /gene="echA1" FT /gene_synonym="ML0120" FT /product="putative enoyl-CoA hydratase" FT /note="Similar to M. tuberculosis Rv3774, putative FT enoyl-CoA hydratase, TR:P75019 (EMBL:AL123456) (274 aa); FT Fasta score E(): 0, 88.3% identity in 274 aa overlap. FT Similar to many e.g. Rattus norvegicus ech1, FT delta3,5-delta2,4-dienoyl-coa isomerase precursor, FT SW:ECH1_RAT (Q62651) (327 aa); Fasta score E(): 3.5e-31, FT 38.8% identity in 276 aa overlap and bacterial putative FT enoyl-CoA hydratases. Contains Pfam match to entry PF00378 FT ECH, Enoyl-CoA hydratase/isomerase family." FT /note="Similar to ML1241, ML1724, ML2118 and ML2402" FT /db_xref="GOA:Q9CD94" FT /db_xref="HSSP:1DCI" FT /db_xref="InterPro:IPR001753" FT /db_xref="UniProtKB/TrEMBL:Q9CD94" FT /protein_id="CAC29628.1" FT /translation="MGSDINRAYESVAVEIKDRVAQVTLIGPGKGNAMGPAFWSEMPEV FT FAELDTNREVRAVVITGSGKDFSYGLDVPAMGGKFVPLLTDGALARPRTDFHAEVLRMQ FT KAINAVADCRTPTIAAVHGWCIGGALDLISAVDIRYASADAKFSMREVKLAIVADMGSL FT ARLPLILSDGHLRELALTGKDIDATRAEKIGLVNDVYDNADKTLAAAHATAAEIAANPP FT LAVYGVKDVLYQQRTSAISESLRYVAAWNAAFLPSKDLTEGISATFAKRAPQFIGE" FT misc_feature complement(161975..162517) FT /note="Pfam match to entry PF00378 ECH, Enoyl-CoA FT hydratase/isomerase family, score 99.60, E-value 6.2e-26" FT CDS complement(163770..164039) FT /transl_table=11 FT /gene="ML0121" FT /product="hypothetical protein" FT /note="Shares region of weak similarity with Streptomyces FT coelicolor SC6A5.32C, hypothetical protein, TR:Q9X7X8 FT (EMBL:AL049485) (155 aa); Fasta score E(): 0.0056, 43.1% FT identity in 58 aa overlap." FT /db_xref="UniProtKB/TrEMBL:Q9CD93" FT /protein_id="CAC29629.1" FT /translation="MVWHMTHSPSSKNTRACPATLGEQKSDEFHARHKINDQSEKASWF FT GKTFKSAACILSLVCVDAGNKDNNAGTLEALIGSMNGKDILDSS" FT RBS complement(164048..164051) FT /note="possible RBS" FT CDS complement(164082..164876) FT /pseudo FT /transl_table=11 FT /gene="hisC2" FT /gene_synonym="ML0122" FT /product="histidinol-phosphate aminotransferase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT hisC2 (Best blastx score 574)" FT tRNA 165035..165127 FT /gene="serT" FT /note="tRNA Ser anticodon GCT, Cove score 56.23" FT tRNA 165147..165219 FT /gene="argU" FT /note="tRNA Arg anticodon ACG, Cove score 76.52" FT CDS 166460..166833 FT /pseudo FT /transl_table=11 FT /gene="ML0123" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3767c (Best blastx score 169)" FT CDS complement(166949..167389) FT /transl_table=11 FT /gene="ML0124" FT /product="conserved hypothetical protein" FT /note="Shows weak similarity to M. tuberculosis Rv2186c, FT hypothetical protein, TR:O53519 (EMBL:AL123456) (144 aa); FT Fasta score E(): 3.7e-06, 27.5% identity in 131 aa overlap FT and Streptomyces coelicolor SC6G10.02C, hypothetical FT protein, TR:Q9X7Y8 (EMBL:AL049497) (144 aa); Fasta score FT E(): 7e-05, 21.9% identity in 137 aa overlap. Previously FT sequenced as TR:O06090 (EMBL:Z95398) (156 aa); Fasta score FT E(): 0, 70.1% identity in 144 aa overlap." FT /note="Similar to ML2629 and shows weaker similarity to FT ML0889" FT /db_xref="InterPro:IPR019587" FT /db_xref="UniProtKB/TrEMBL:Q9CD92" FT /protein_id="CAC29632.1" FT /translation="MPVLSKTVEIDTDTATIMAIVTDFESYPQWHEWIKGVWVLAHYDD FT GRPSQLRIDINFQGMQGTYIQAVYYPGVNQIQTVMQQGDLYSKQEQLFSVTQAEGGSVL FT TVDLDVELTMPVPAPMVKMLLNTALDRLAEKLKLYAEHLAPS" FT CDS 167598..168914 FT /transl_table=11 FT /gene="ML0125" FT /product="putative glycosyl transferase" FT /note="Similar to M. tuberculosis Rv2958c, putative FT glycosyl transferase, TR:P95134 (EMBL:AL123456) (428 aa); FT Fasta score E(): 0, 74.6% identity in 418 aa overlap and FT Rv2962c, putative glycosyl transferase, TR:P95130 FT (EMBL:AL123456) (449 aa); Fasta score E(): 0, 77.5% FT identity in 426 aa overlap. Similar to Streptomyces FT venezuelae desVII, glycosyl transferase from a macrolide FT antibiotic biosynthesis gene cluster, TR:Q9ZGH7 FT (EMBL:AF079762) (426 aa); Fasta score E(): 1e-09, 30.0% FT identity in 237 aa overlap. Shows similarity to bacterial FT and eukaryotic glycosyl transferases." FT /note="Similar to ML0128 and shows weaker similarity to FT ML0985" FT /db_xref="GOA:Q9CD91" FT /db_xref="InterPro:IPR002213" FT /db_xref="UniProtKB/TrEMBL:Q9CD91" FT /protein_id="CAC29633.1" FT /translation="MGKDAGMSTAPDTVPECQSRRMRILFIAEAVTLAHVVRPFAVARL FT LDPSRYEVHFACDPRYNNLLGPLPFPHHPIHTVPSKRFLDNMAQGRLFLYGPRTLRKYV FT EEDSKLLSEIEPDLVVGDLRWSLSVSARLASIPYIAIANAYWSSHARRRFPLPDVLYTH FT LLGVRLVKLLYRLERPLFFAFQCLPLNWVRRKHGLPSLGFNLCRIFTDGDYTLYADVPE FT LVPTYDLPANHQYLGPVLWSPAGELPRWWDSLPTDRPIVYATLGTSGGKNLLQVVLDAL FT ADLPVTVIAATAGRSELQNVPANAFVADYLPGEAAAARSAVVICNGGSLTTQQAFVAGV FT PVVGIAGNLDQHLNMEAVEAAGAGILLRSERLKVRRVADAVNRVLGQSEYRQAAQRLAE FT VLERHVAGLPQHMENVLHTVSQNPPPTSLARQKRPLRFG" FT repeat_region 167887..168892 FT /note="1006 bp repeat, 96% identical to region FT 171902..172907 in ML0128" FT RBS 169572..169578 FT /note="possible RBS" FT CDS 169585..170406 FT /transl_table=11 FT /gene="ML0126" FT /product="hypothetical protein" FT /note="Unknown function." FT /db_xref="UniProtKB/TrEMBL:Q9CD90" FT /protein_id="CAC29634.1" FT /translation="MRAAEASKALMWRIIEESWNNAQFYFAKDHHRIKVVQQALNGWEA FT PVYLEIGVSHGFVFRRVAADVKIAVDPACKLSARSRRLAAAKARATHYFEMTSDAFFAD FT ETAFLEQRGIDVALIDGLHTYGQVVRDVENTLRYLRDDGIIVLHDCNPKQASVAYPATS FT YADFRAHNHWWNGPWSGDVWKSIVHLRSTRHDLRIAVLDCDWGVGIIRKGSPESPLSYS FT AAQIEALNYEDLVADRGCLLNLRPPAYLDDFLSLQRSISPNSYNTARVDPA" FT RBS 170650..170655 FT /note="possible RBS" FT CDS 170662..171351 FT /transl_table=11 FT /gene="ML0127" FT /product="hypothetical protein" FT /note="Similar to M. tuberculosis Rv2959c, hypothetical FT protein, TR:Q50457 (EMBL:AL123456) (245 aa); Fasta score FT E(): 0, 76.1% identity in 226 aa overlap. Shows weak FT similarity to Streptomyces clavuligerus cmcI, cephalosporin FT hydroxylase component of 7 alpha-cephem-methoxylase, FT TR:O85726 (EMBL:AF073896) (236 aa); Fasta score E(): FT 0.0001, 27.6% identity in 163 aa overlap and to other FT hypothetical proteins." FT /db_xref="GOA:Q9CD89" FT /db_xref="InterPro:IPR007072" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD89" FT /protein_id="CAC29635.1" FT /translation="MERVRQMFSCVSGMIYRPTDSIAEEYHKWYYGNFVWNTTTWMGIK FT CLKSVSDMWNYQEILIELEPSLVIEFGSRFGGSALFFANVMMHIGQPFKVLSVDISHKD FT LDPAARQPDILFIESPSTAPAIAEQIRRLKNEYPGKIFAILDSDHSMKQVLAEMKLLQP FT LLTAGDYLVVEDSNLNGHPVLPRFGAGPYEAIEAYEREFPGDYEHDVAREKKFGFTFAT FT NGFLIRK" FT CDS 171616..172923 FT /transl_table=11 FT /gene="ML0128" FT /product="putative glycosyl transferase" FT /note="Similar to M. tuberculosis Rv2958c, putative FT glycosyl transferase, TR:P95134 (EMBL:AL123456) (428 aa); FT Fasta score E(): 0, 75.1% identity in 417 aa overlap and FT Rv2962c, putative glycosyl transferase, TR:P95130 FT (EMBL:AL123456) (449 aa); Fasta score E(): 0, 74.4% FT identity in 425 aa overlap. Similar to Streptomyces FT venezuelae desVII, glycosyl transferase from a macrolide FT antibiotic biosynthesis gene cluster, TR:Q9ZGH7 FT (EMBL:AF079762) (426 aa); Fasta score E(): 1.1e-09, 30.9% FT identity in 223 aa overlap. Shows similarity to bacterial FT and eukaryotic glycosyl transferases." FT /note="Similar to ML0125 and shows weaker similarity to FT ML0985" FT /db_xref="GOA:Q9CD88" FT /db_xref="InterPro:IPR002213" FT /db_xref="UniProtKB/TrEMBL:Q9CD88" FT /protein_id="CAC29636.1" FT /translation="MGKDAGMSTAPDTVPECQSRRMRILFIAEAVTLSTVVRPFAVARL FT LDPSRYEVHFACDPRYNNLLGPLPFPHHPIHTVPSEWVLTRIAQGRLFYTTRTLRKYVE FT EDSKLLSEIEPDLVVGDARWSLSVSARLASIPYIAIANAYWSSHARRRLPLPDVLWTRI FT LGVRLVNILFRLYSPLIFAIYCLPLNWVRRKHGLPSLGSNIGCIYTDGDYTLYADVPEL FT VPTYDLPANHQYLGPVLWSPAGELPRWWDSLPTDRPIVYATLGTSGGKNLLQVVLDALA FT DLPVTVIAATAGRSELQNVPANAFVADYLPGEAAAARSAVVICNGGSLTTQQAFVAGVP FT VVGIAGNLDQHLNMEAVEAAGAGILLRSERLKVRRVADAVNRVLGQSEYRQAAQRLAEV FT LERHVAGLPQHMENVLHTVSQNPPPTSLARQNETTT" FT repeat_region 171902..172907 FT /note="1006 bp repeat, 96% identical to region FT 167887..168892 in ML0125" FT CDS complement(173170..174426) FT /transl_table=11 FT /gene="ML0129" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2953, conserved FT hypothetical protein, TR:P95139 (EMBL:AL123456) (418 aa); FT Fasta score E(): 0, 86.6% identity in 418 aa overlap and to FT Rv2449c, conserved hypothetical protein, TR:O53176 FT (EMBL:AL123456) (419 aa); Fasta score E(): 0, 64.9% FT identity in 419 aa overlap. Similar to many bacterial FT hypothetical proteins." FT /db_xref="GOA:Q9CD87" FT /db_xref="InterPro:IPR005097" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD87" FT /protein_id="CAC29637.1" FT /translation="MSPDKREFDIVLYGATGFSGKLTAEHLALSESTARIALAGRSSER FT LRNVRALLGPNAQDWPLIVADASQPSTLEAMAGRAQVVLTTVGPYTRYGLPLVAACART FT GTDYADLTGELMFCRNSIDLHHKQAAATGARIILACGFDSVPSDLNVYQLYRRVIEDRT FT GELCDTDLVLRSFSQRWVSGGSVAAYSEAMLTTSNDPEALRLVTDPYTLTTDRDAEPDL FT GPQPDFPRHRGSDLAPELAGFWTGGFVQAQFNTRIVRRSNALQNWSYGRQFRYSETMSL FT GKSWAAPVASAAVTSVVAGAVGLGNKYFNRLPRRVVERVTPKSGTGPSRKTQARGHYTF FT ETYTTTTTGARYMATFAHNVDAYKSTAGLLAASGLTLALDRDRLSELRGVLTPAAAMGE FT ALLTRLPSAGVVIGTTRLS" FT CDS complement(174466..175278) FT /transl_table=11 FT /gene="ML0130" FT /product="conserved hypothetical protein" FT /note="Similar to M.tuberculosis Rv2952, hypothetical FT protein, TR:Q50464 (EMBL:AL123456) (270 aa); Fasta score FT E(): 0, 83.7% identity in 270 aa overlap. Similar to in FT part to Streptomyces hygroscopicus rapM, methyltransferase FT involved in rapamycin biosynthesis, TR:Q54303 (EMBL:X86780) FT (317 aa); Fasta score E(): 5e-14, 38.6% identity in 158 aa FT overlap and shows weak similarity to CDS associated with FT several gene clusters encoding polyketide biosynthesis." FT /db_xref="GOA:Q9CD86" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD86" FT /protein_id="CAC29638.1" FT /translation="MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWA FT YEEDPPMALPLEASDEPNRAHINLYHRTATQVNLSGKRILEVSCGHGGGASYLTRALHP FT ASYTGLDLNPAGIKLCQKRHQLPGLEFVRGDAENLPFDNESFDVVINIEASHCYPHFPR FT FLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANSRLQQLSQREINAEVLRGIASNSQ FT KSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYSFAKD" FT CDS 175441..176589 FT /transl_table=11 FT /gene="ML0131" FT /product="putative oxidoreductase" FT /note="Similar to M. tuberculosis Rv2951c, putative FT oxidoreductase, TR:P95140 (EMBL:AL123456) (381 aa); Fasta FT score E(): 0, 84.8% identity in 382 aa overlap. Similar to FT Archaeoglobus fulgidus AF2411, conserved hypothetical FT protein, TR:O30260 (EMBL:AE001109) (363 aa); Fasta score FT E(): 0, 31.5% identity in 362 aa overlap. Shows weak FT similarity to bacterial oxidoreductases e.g. Mycobacterium FT smegmatis fgd, F420-dependent glucose-6-phosphate FT dehydrogenase, TR:O68447 (EMBL:AF041061) (336 aa); Fasta FT score E(): 1.1e-09, 27.7% identity in 292 aa overlap." FT /note="Shows weak similarity to ML0269" FT /db_xref="GOA:Q9CD85" FT /db_xref="InterPro:IPR011251" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD85" FT /protein_id="CAC29639.1" FT /translation="MAGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLN FT ALVPRSVATPKYLGVAAKVVPKIDANYEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRNP FT AVTAQAAATLHLLTRGKAMLGIGVGEREGNEPYGVEWTKPVARFQEALATIRALWDSNG FT ELVSRESQFFPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLVRPTD FT YSCALEVVRTAASDAGRDPMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEA FT WARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPAALMKEVLFSGTPEEVIDQVA FT EWRDHGLKYLVVINGSLVNSSLRKTVSALLPHARVLRGLKKL" FT CDS 177170..179212 FT /transl_table=11 FT /gene="fadD29" FT /gene_synonym="ML0132" FT /product="putative acyl-CoA synthetase" FT /note="Similar to several putative acyl-CoA synthases from FT M. tuberculosis e.g. M. tuberculosis Rv2950c, fadD29, FT putative acyl-CoA synthase, TR:P95141 (EMBL:AL123456) (619 FT aa); Fasta score E(): 0, 80.2% identity in 620 aa overlap. FT Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, FT TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 58.5% FT identity in 585 aa overlap and to domains of polyketide FT synthases e.g. Myxococcus xanthus safB, saframycin Mx1 FT synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta FT score E(): 0, 36.2% identity in 589 aa overlap. Contains FT Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme." FT /note="Similar to ML0100, ML0138, ML1234 and ML2358" FT /db_xref="GOA:Q9CD84" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q9CD84" FT /protein_id="CAC29640.1" FT /translation="MLRRVISLVVSAKSHVLYPAIVGPHQISRRGAGPSMKRRLGFEDT FT VAKRSYLLAVKSRRIIMKANVSFHARGEVATQPAQGPPEQTGQLVNGTATRFAMGESML FT TDLLQKAASQFPNRAAYKFIDYDVDPAGFTETLTWWQVYRRSMSVAYELRIYASDGDRV FT AILAPQGLEYIVAFMGALQAGLIAVPLPAPQFGIHDERISAALRDSLPSVIITTSAAIV FT EVTKYAPHARSAQGSAPVVVAVDVLDLDSPRELDPSRYERLNTAYLQYTSGSTRAPAGV FT IVSHKNVITNCVQLMSDYLGDIEKVPSTAVSWLPFYHDMGLILGVILPMVNQDTAVLLS FT PMAFLQRPARWMQLLGKYRGQISCAPNFGFELAVRRTSDDDMAGLDLGHVRAIATGAER FT VNAATLQRFTERFARFNLDETAIRPSYGLAEATVYVATAGPGRPPKSICFDYQHLSAGK FT AKRSANGAGDGVNLVSYGAPRASVLRIVDPDTRIETSEGTVGEIWVQGDNVARGYWRNP FT ENTERTFGGQLVNPSPGTPDGPWLRTEDLGVIFEGELFITGRIKDLLVVDGSNHYPDDI FT EATIQEITGGRVVAIAVPDDCTEQLVTIIELTKWGYADCDAMEKLCTVKREVTSAVSKS FT HRVRVADVVIVAPGSIPVTTSGKVRRAACVERYLNHEFNRLDATA" FT misc_feature 177581..178942 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score -14.90, E-value 1.4e-14" FT CDS 179256..179888 FT /transl_table=11 FT /gene="ML0133" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv2949c, hypothetical FT protein, TR:O86325 (EMBL:AL123456) (199 aa); Fasta score FT E(): 0, 62.6% identity in 195 aa overlap. Shows weaker FT similarity to Archaeoglobus fulgidus AF1396, hypothetical FT protein, TR:O28875 (EMBL:AE001008) (162 aa); Fasta score FT E(): 4.2e-05, 26.6% identity in 154 aa overlap. Contains FT Pfam match to entry PF01947 DUF98, Protein of unknown FT function." FT /db_xref="GOA:Q9CD83" FT /db_xref="InterPro:IPR002800" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD83" FT /protein_id="CAC29641.1" FT /translation="MTNRTLSREEIRKLDRDLRILVATNGTLTRVLNVVANEEIVVDII FT NQQLLDVAPKIPELENLKIGRILQRDILLKGQKSGILFVAAESLIVIDLLPTAITTYLT FT KTHHPIGEIMAASRIETYKEDAQVWIGDLPCWLADYGYWDLPKRAVGRRYRIIAGGQPV FT IITTEYFLRSVFQDTPREELDRCQYSNDIDTRSGDRFVLHGRVFKNL" FT misc_feature 179295..179786 FT /note="Pfam match to entry PF01947 DUF98, Protein of FT unknown function, score -37.20, E-value 0.0013" FT CDS 180027..182150 FT /transl_table=11 FT /gene="fadD22" FT /gene_synonym="ML0134" FT /product="putative acyl-CoA synthetase" FT /note="Similar to M. tuberculosis Rv2948c, acyl-CoA FT synthase, TR:P96283 (EMBL:AL123456) (705 aa); Fasta score FT E(): 0, 75.9% identity in 705 aa overlap. Similar to many FT acyl-CoA synthases e.g. Rhodopseudomonas palustris, badA, FT benzoate-coenzyme A ligase, TR:Q59760 (EMBL:L42322) (521 FT aa); Fasta score E(): 0, 31.4% identity in 494 aa overlap. FT Contains Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site. Contains Pfam match to FT entry PF00501 AMP-binding, AMP-binding enzyme." FT /note="Similar to ML1051, ML1994, ML2257 and ML2546" FT /db_xref="GOA:Q9CD82" FT /db_xref="HSSP:1LCI" FT /db_xref="InterPro:IPR009081" FT /db_xref="UniProtKB/TrEMBL:Q9CD82" FT /protein_id="CAC29642.1" FT /translation="MRSENLAALLARQAAEAGWYDKPAYFAPDVVTHGQIHDGAVRLGE FT VLRNRGLSAGDRVLLCLPDSPDLVQLLLACLARGIMAFLANPELHRDDYAFPERDTAAA FT LVITNGSLRDRFQSSNVVEPAELLSDATRVEPSDYEPVSGDAYAFATYTSGTTGKPKAA FT IHRHADPFTFVDAMCRKALRLTPQDIGLCSARMYFAYGLGNSVWFPLATGGSAVISSVP FT VSAESAAMLSTRFEPSVLYGVPSFFARVVGACSPDSFRSLRCVVTAGEALEPALAERLV FT EFFGGIPILDGIGSSEVGQTFVSNSVDDWRVGTLGKVLPPYEIRVVAPDGATAGSGIEG FT NLWVRGPSIAQSYWNRPDSLLENGDWLNTRDRVRIDGDGWVTYGCRADDTEIVGGVNIN FT PREVERLIIEADAVAEAAVVGVREFTGASTLQAFLVPAVGAFIDESVMRDVHRRLLTQL FT TAFKVPHRFAIIERLPRSTNGKLLRNVLRAQSPTKPIWELSLTESQSATKAQLDGRPAS FT NAHAQAAVGHAAGATLKQRLSALQQERERLVVEAVCAEAVKMLGESDPGLINRDLAFSD FT LGFDSQMTVTLCNRLAVVTGLRLPETVGWDYGSISGLSRYLEAELSGVRSRPETPLSAN FT SGAKGLSPIDEELKKVEEMVVAIGASEKQRVADRLRALLGIIVDGEAGLSKRIQAASTP FT DEIFQLIDSELCE" FT misc_feature 180120..181280 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 66.50, E-value 4e-19" FT misc_feature 181674..181877 FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 43.60, E-value FT 2e-10" FT RBS 182156..182160 FT /note="possible RBS" FT CDS 182173..188484 FT /transl_table=11 FT /gene="ML0135" FT /product="putative polyketide synthase" FT /note="Similar to many polyketide synthases from M. FT tuberculosis e.g. N-terminus is similar to Rv2947c, pks15, FT probable polyketide synthase, TR:P96284 (EMBL:Z83858) (496 FT aa); Fasta score E(): 0, 90.5% identity in 485 aa overlap FT and the remainder is similar to Rv2946c, pks1, probable FT polyketide synthase, TR:P96285 (EMBL:Z83858) (1616 aa); FT Fasta score E(): 0, 82.5% identity in 1620 aa overlap. FT Similar to many others e.g. Streptomyces noursei NysC, FT nystatin biosynthesis polyketide synthase, TR:AAF71776 FT (EMBL:AF263912) (11096 aa); Fasta score E(): 0, 50.2% FT identity in 2161 aa overlap. Contains Pfam match to entry FT PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains FT Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl FT synthase. Contains Pfam match to entry PF00698 Acyl_transf, FT Acyl transferase domain. Contains Pfam match to entry FT PF00550 pp-binding, Phosphopantetheine attachment site. FT Contains PS00012 Phosphopantetheine attachment site. FT Contains PS00606 Beta-ketoacyl synthases active site." FT /note="Similar to ML0101, ML0139, ML1229, ML2353, ML2354, FT ML2355, ML2356 and ML2357" FT /db_xref="GOA:Q9CD81" FT /db_xref="HSSP:1PQW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CD81" FT /protein_id="CAC29643.1" FT /translation="MTASVEGADQKSEKLISYLKKVVVELDETRARLREYEQRATEPVA FT VVGIGCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWG FT AFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGVFTG FT IFAPSYGSRDTGGLQGYGLTGTAVSVASGRVSYVLGLEGPAVSVDTACSSSLVAIHWAM FT SSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVV FT VLERLSDAQRLGHTVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADV FT DVVEAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAGVAGVIKM FT VQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVEGRPRRAGVSSFGISGTNA FT HVILEEAPTPVEASYSTADQQRLSVVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVD FT VGCALAARSVFEHRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPGQ FT GAQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGADAGLLDSTEFAQPAL FT FAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPADAAMLVVARGRLMQSMPA FT GGTMWAVAASEDEVVSLLGEGVGIAAINAPESVVISGPQAAVSAIADKFAAQGRRVHQL FT AVSHAFHSPLMEPMLEEFVRVAAQVEVRKPQIGLVSNVTGELAGPDFGSPQYWGEHVSR FT AVRFVDSARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAVVVSMMGKDRPELASVLG FT AAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDGTASVSGLGLGSTE FT HALLGAVVERPDSGGVVLTGRLSLANQPWLADHVIGGVVLFPGAGFVELVIRAGDEVGC FT AGVEELVLAAPLVLHPGSGVQVQVVVAAADESSRRAVSVYSRGDQSHGGWLLNAEGLLE FT VDAAEATVDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQGLVAIWRRGSELFAEVV FT APTGVVVDGMGMHPALLDAVLHALGLAIENTQATTEMRLPFCWRGVSLHAGGAGRVRAR FT FTSAGADAIAVDIADSAGLPVLTVRSLVTRAMTAEQLRTAVTAAGGALEQGPMDLVWSP FT IPLSSDGHGGGLPSVVSWADYCAGRGNDTGVVVWEFGSASAGAQAPVDSVAAVYSATHA FT ALQVLQFWFGQDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSGKIVLID FT TDSAVDVAVLADLGESQLLVRCNTVHAARLSPAPQLLALPVGESMWRLAADGGGTLEDL FT VIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVIEIGPE FT VTGVAVGDAVMGFLGGAGPLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAG FT IRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTASRGKWDTLRDMGFDDDHIGDSRTL FT EFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYP FT GVQYRAFDLSEAGPVRMQEMLCEVRELFDTQVLHRLPVTSWDVRCAPAAFRFMSQARHI FT GKVVLTMPSALADGLAEGTVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDRAEGA FT VELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDGAITSL FT TPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAANAFLDGL FT AAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPAQALELFDAALV FT IDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQ FT GLAANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATG FT LTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVSVHA" FT misc_feature 182302..183570 FT /note="Pfam match to entry PF00109 ketoacyl-synt, FT Beta-ketoacyl synthase, score 753.90, E-value 6.6e-223" FT misc_feature 182776..182826 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 183877..184821 FT /note="Pfam match to entry PF00698 Acyl_transf, Acyl FT transferase domain, score 226.70, E-value 3.4e-64" FT misc_feature 186370..187281 FT /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding FT dehydrogenases, score -67.70, E-value 3.9e-06" FT misc_feature 188185..188388 FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 76.30, E-value FT 1.7e-19" FT misc_feature 188263..188310 FT /note="PS00012 Phosphopantetheine attachment site" FT RBS 188537..188540 FT /note="possible RBS" FT CDS 188551..189252 FT /transl_table=11 FT /gene="lppX" FT /gene_synonym="ML0136" FT /product="putative lipoprotein" FT /note="Similar to M. tuberculosis lipoproteins e.g. M. FT tuberculosis lppX, putative lipoprotein, SW:LPPX_MYCTU FT (Z83858) (233 aa); Fasta score E(): 0, 76.4% identity in FT 233 aa overlap. Similar to Mycobacterium bovis lprG, 27 kDa FT lipoprotein antigen, SW:LPRG_MYCTU (AJ000500) (236 aa); FT Fasta score E(): 2.5e-13, 31.2% identity in 202 aa overlap. FT Contains a probable N-terminal signal sequence. Contains FT PS00013 Prokaryotic membrane lipoprotein lipid attachment FT site." FT /note="Similar to ML0557" FT /db_xref="GOA:Q9CD80" FT /db_xref="InterPro:IPR009830" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD80" FT /protein_id="CAC29644.1" FT /translation="MNDRKWVTSSVMLVTLSACLALGLSGCSSTKPDAQEQSSSSSPAS FT SDPALTAEIKQSLETTKALSSVHVVVQTTGKVDALLGISNADVDVQANPLAVKGTCTYN FT DQPGVPFRVLGDNISVKLFDDWSNLGSISDLSTSHVLDPNTGITQVLSGVINLQAQGTE FT VVDRIPTNKITGTVPTSSVKMLDPKAKGSKLATVWIAQDGSHHLVRASIDLGSGSIQLT FT QSKWNEPVNTN" FT misc_feature 188575..188607 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(189253..191961) FT /transl_table=11 FT /gene="mmpL7" FT /gene_synonym="ML0137" FT /product="putative membrane protein" FT /note="Similar to members of the M. tuberculosis mmpL FT family of membrane proteins e.g. Rv2942, mmpL7, putative FT membrane protein, SW:MML7_MYCTU (P96289) (920 aa); Fasta FT score E(): 0, 68.6% identity in 881 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /note="Similar to ML1231 and ML2378. Similar to pseudogene FT ML2375" FT /db_xref="GOA:Q7AQN7" FT /db_xref="InterPro:IPR004869" FT /db_xref="UniProtKB/TrEMBL:Q7AQN7" FT /protein_id="CAC29645.1" FT /translation="MSTDDSHRSLRLANLLVITAWITAVVIANLIFTLTQAKLRDKNSV FT LLPQDTMTVTTTNQIAQAFPGTGTNAIAYLVVEGNRTLEPEDQPYYDSAVNALRADTHD FT VGSVLDWWSDPLTAPLGTSPDSRSAIALIWLQGEAGTTRARASLGAIRSVVRQLPPSEE FT LRARIVVPATTNNMPMEMTAWQGMAIVTAAAVIAILFLLRARQAIRIVVIMLLTADFSL FT AAAWPLAAVVQRQTGGTVSVFSWNLAAVLTIGTITASTLLASRSYTGDSAAPTCRAHLP FT ALALLGACVALLTGTLLLARTPALHSVGTVALGVVVALAASLTLLPTLIKLAGPSGQIS FT PQVNGNTWTRRLLVPNFSSPARLTAVVLATCALPVIGMRLGLAEDHTAQSGTQILPGNL FT LPDILLIKSARDLRDPAALIAIDQVSHRLMEIPGVRKVESAAWPAGVPWNDASLSSAAG FT RLADQMSQQAGSFVPAVTAIKQMKTMIDQMSSTVDELESTVNVALAGAHQVQQYLNPVL FT SAARNIKSKTAEFSGYLDTVRGWVVSVTNCPNDVLCSAMRKVIEPYDKVAASMDQLSNG FT VDRISAISDQTISSFNEAPHMVAQMRSALKQARSFIPRLESTIQELMPQIAQASAMLKN FT LSRDFADTGEGGFHLPMKELMSSSYQHVRESMFSSDGTATRLVVYTNEHNPGLDTAARA FT QQLEIAAGKAMKYGSLVDSRITLGGAAQVAVAARAALTHDAVLLAGMLFAVVALASMWV FT SAGSGVAVGLGVLAAYLGGLGISVALWQHILGHELQASVPLVSFAILAPCGVLYLVTSL FT EAARVSAEAKTAATVSVRRAVVPLTVLGAIFGAGLVVAEASFSALSQVGTVLVIALGAL FT TKVEQVLISYHAEAAMPAWSKLPSRLSGGPN" FT CDS complement(192013..193752) FT /transl_table=11 FT /gene="fadD28" FT /gene_synonym="ML0138" FT /product="acyl-CoA synthetase" FT /note="Similar to several putative acyl-CoA synthases from FT M. tuberculosis e.g. M. tuberculosis Rv2941, fadD29, FT putative acyl-CoA synthase, TR:P96290 (EMBL:AL123456) (580 FT aa); Fasta score E(): 0, 81.9% identity in 580 aa overlap. FT Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, FT TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 81.4% FT identity in 580 aa overlap and to domains of polyketide FT synthases e.g. Myxococcus xanthus safB, saframycin Mx1 FT synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta FT score E(): 0, 35.8% identity in 590 aa overlap. Contains FT Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme." FT /note="Similar to ML0100, ML0132, ML0243, ML1234, ML2358" FT /db_xref="GOA:Q9CD79" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q9CD79" FT /protein_id="CAC29646.1" FT /translation="MSVRSIPAVLRTCARLQPNDPVFTFMDYEQDWDGVKITLTWSQLY FT RRTLNVAQELNRCGSTGDRVAISAPQGLDYVVAFLGALQAGRIAVPLSVPQGGVTDERF FT ESVLNDSSPVAILTTSPAVDDVVHHVTQRPDESTPSIIEVDLLDLDSPNGSGDGNGDHL FT STAYLQYTSGSTRTPAGVMISHHNLRANFEQLMSTYLADTDGVFPVGGMSVSWLPFYHD FT MGLILGVCVPILGGCPAVLTSPVSFLQRPARWMHMLASEFPVFSAAPNFAFELATKKIS FT DDDMIGVDLGNIHIILNGSERVQPATIKRFNNRFARFNLKEKAVRPSYGLAEATVYVAT FT SRSGQPAELVDFDAESLSTGQAKTCTSGNGTSLISYVLPPSPIVRIVDSDTCIQCQDGT FT VGEIWVHGDNVADGYWQKPDESERTFGGKIAAPSRGTPEGPWLRTGDSGFVIDGKMFII FT GRIKDLLIVYGRNHSPDDIEGTIQEITRGRCAAISVPDRNTEKLVAIIELKKLGDADQY FT AMDRLGAIKREVISALSNSHGLSVSDVVLVAPGSIPITTSGKVRRSTCVERYRQDQFDR FT LDA" FT misc_feature complement(192277..193635) FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score -8.20, E-value 5.9e-15" FT RBS 194207..194210 FT /note="possible RBS" FT CDS 194221..200571 FT /transl_table=11 FT /gene="mas" FT /gene_synonym="ML0139" FT /product="putative mycocerosic synthase" FT /note="Similar to many polyketide synthases from M. FT tuberculosis e.g. Rv2940c, mas, mycocerosic acid synthase, FT TR:P96291 (EMBL:AL123456) (2111 aa); Fasta score E(): 0, FT 88.0% identity in 2119 aa overlap. Similar to Mycobacterium FT bovis mas, mycocerosic acid synthase, SW:MCAS_MYCBO FT (Q02251) (2110 aa); Fasta score E(): 0, 85.1% identity in FT 2122 aa overlap. Contains Pfam match to entry PF00107 FT adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match FT to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. FT Contains Pfam match to entry PF00698 Acyl_transf, Acyl FT transferase domain. Contains Pfam match to entry PF00550 FT pp-binding, Phosphopantetheine attachment site. Contains FT PS00012 Phosphopantetheine attachment site. Contains FT PS00606 Beta-ketoacyl synthases active site." FT /note="Similar to ML0101, ML0135, ML1229, ML2353, ML2354, FT ML2355, ML2356 and ML2357" FT /db_xref="GOA:Q9CD78" FT /db_xref="HSSP:1PQW" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9CD78" FT /protein_id="CAC29647.1" FT /translation="METSVTPIAVIGMGCRLPGGINSPDKLWESLLRGDNLVTEVPPDR FT WDVDDFYDPEPGVPGRSVSRWGGFLDDVAGFDAEFFGISEREATSIDPQQRLLLETSWE FT AIEQGGLDPASLAGSSTAVFTGLTHEDYLVLTTAAGGLASPYVVTGLNNSVASGRISHT FT LGLHGPAMTFDTACSSGLMAVHLACRSLHDGESDLALAGGCAVLLEPHASVAASAQGML FT SSTGRCKSFAADADGFVRSEGCAMVLLKRLPDALRDGNRIFAMILGTATNQDGGTETLM FT MPSEDAQVAVYQAALAVAGVEPETIGVVEAHGTGTPIGDPIEYRSLARVYGAGTPCALG FT SAKSNMGHSTASAGTVGLIKAILSLRNGLVPPLLHFDRLSDDLTEIETGLFVPQEVTPW FT PVGGYNTPKRVAVSSFGMSGTNVHVIVEEAPSEACAPDVPETSPGTGDATVGRQLFMLS FT STSIAALRETARQLATWVEEHQDSVVLSDLAYTLARGRAHRPVRTAVVAADLPELVEGL FT CEIADGDALYDAVVGHGDRGPVWVFSGQGSQWASMGVQLLANEPVFAATITKLEPVIAA FT ESSFSVTEAITAPETVTGIDKVQPSVFAVQVALATTMEQTYGVRPGAVIGHSMGESAAA FT VVAGALSLEDAARVICRRSKLMNRVAGSGAMGSVELPAKQVNSELMARGIDDVVISVVA FT SPQSTVIGGATETVRDLIAQWEQRDVMAREVAVDVASHSSQVDPILDDLAAALADIAPM FT TPKVPYYSATLFDPRELPVCNGAYWVDNLRNTVQFAAAVQAAMEDGYRVFAELSPHPLL FT THAVEQTARNLDMSVAALAGMRREQSMPYGLRGLLADLHSAGAALDFAALYPAGRLLDA FT PLPVWTHPRLFIDTDGQEQRAQGACTVTVHPLLGSHVRLLEEPERHIWQGDVGTAALSW FT LADHQVHNVAALPGAAYCEMALAAAVEVFGEAAEVRAIAFEQMLLLAAETPIDAIASVD FT APGVINFVVQANQDGEKMRNATATLHAAEDDCPPPAYDIAALLEAHPNSVNGTDLRESF FT AERGVQLGAAFAGLATAHTAEAESGTVLAEVALPASIRFQQSSYQIHPALLDACFQSVG FT AGVDATKVGSRAGLLLPLGVRSLRVYRPTRNARYCYTRLTKIEPRGGEADLDVLDEHGA FT VLLAVRGLHMGTGTTERGELDRQLSERLLTIGWQQRTLPESVHVEPGSWLLIDTFNASA FT IPDMWASTLTDALKSYGTQGTECTNLSWLIQDDPVVSRERLGRQLRGRDGVVILCGPRA FT GAPDEQSLLAAREQVRHLVRIIRELAELEGELPRLFVVTRQAQIVQSGDAANLEQAGLR FT GLLRVISSEHPMLRTTLVDVDEHTDVERVAQQLLSGSEEDETAWRNGDWYVARLNPSPL FT SHEDRRTVVLNPEHDGLRVHVRKPGDLQSLELVASDRVPPGPGQLEVAVSMSSINFADV FT LIAFGRFPIIDDRDPQLGMDFVGVVTAVGEGVTGHQIGDRVGGFSEGGCWRTFLTCDAN FT LAVTLPSGLTDEQAITAATAHATAWYGLNDLAGIKVGDKVLIHSATGGVGQAAISIARA FT KGAEIFATAGNPTKRAMLHDLGIEHVYDSRSVEFAEQIRRDTDGYGVDIVLNSLTGAAQ FT RAGLELLTFGGRFVEIGKADVYGNTRLGLFPFRRGLTFYYLDLALMSVTQPDRVRELLA FT TVFNLTADGVLTAPECTHYPLTDAANAIRAMSNAEHTGKLVLDIPRTGSRSVAVPPEQA FT PVYRRDGSYIITGGLGGLGLFFASKLAEAGCGRIVLTARSQPNPKARQTIERLCAAGAD FT IVVECGNIAEPYTADRLVNAATATGLPLRGVLHSAAVVEDATLTNITDELIDRDWSPKV FT YGSWNLHCATIGQPLDWFCLFSSGAALLGSPGQGAYAAANSWVDLFAHWRRAQGLPVSA FT IAWGAWGEVGRATFLAEGGEIMITPDEGAYAFEMLVRYDRPYSGYIPILGAPWLPDLVR FT RSPWAEMFSSAGQGSRGPSKFRMELLALPQDEWSGRLRRLLVEQASVILRRTIDADRSF FT IEYGLDSLGMLEMRTHIESETGIRLTPKVIATNNTARALAQYLADTLAEEEGVAAPAAM FT VSPETP" FT misc_feature 194242..195510 FT /note="Pfam match to entry PF00109 ketoacyl-synt, FT Beta-ketoacyl synthase, score 619.80, E-value 1.6e-182" FT misc_feature 194722..194772 FT /note="PS00606 Beta-ketoacyl synthases active site" FT misc_feature 195832..196791 FT /note="Pfam match to entry PF00698 Acyl_transf, Acyl FT transferase domain, score 500.60, E-value 1.2e-146" FT misc_feature 198499..199440 FT /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding FT dehydrogenases, score -26.80, E-value 2.5e-08" FT misc_feature 200299..200502 FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 71.50, E-value FT 3.6e-18" FT misc_feature 200377..200424 FT /note="PS00012 Phosphopantetheine attachment site" FT CDS 200930..201848 FT /pseudo FT /transl_table=11 FT /gene="ML0140" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv0221 (Best blastx score 157)" FT CDS complement(202307..202561) FT /transl_table=11 FT /gene="ML0141" FT /product="hypothetical protein" FT /note="Improbable CDS suggested by GC frameplot. Possibly FT the remains of a disrupted gene." FT /db_xref="UniProtKB/TrEMBL:Q9CD77" FT /protein_id="CAC29649.1" FT /translation="MRLKVIDSPASTRTNRIVLQEHLHLSVGNRGGTGMRGGYSLFNVP FT VDPYMKMIHTPRHVPEAPRPTSHGTSRGFVYTPMDRSAS" FT CDS 204363..204611 FT /transl_table=11 FT /gene="ML0142" FT /product="possible membrane protein" FT /note="Unknown function. Contains hydrophobic, possible FT membrane-spanning region." FT /db_xref="UniProtKB/TrEMBL:Q9CD76" FT /protein_id="CAC29650.1" FT /translation="MIAAIPPEPTSTYLVLLQIGMYGMMLLTGVPVLIQAVLPELLRRD FT FDHDLVHQPETMNLFVELFVPYLLATGYTGSLSPTTR" FT repeat_region complement(204703..207085) FT /note="Dispersed repeat, LEPREP, copy 1" FT CDS complement(204890..204988) FT /pseudo FT /transl_table=11 FT /gene="ML0143" FT /note="Similar to Agrobacterium tumefaciens transposase FT TR:Q44454 (EMBL:Z18270) (366 aa) fasta scores: E(): 0.0002, FT 51.5% id in 33 aa, and to Pseudomonas putida transposase FT tnpa1 TR:Q9R9U9 (EMBL:AJ245436) (355 aa) fasta scores: E(): FT 0.00088, 48.5% id in 33 aa" FT CDS complement(205253..206396) FT /pseudo FT /transl_table=11 FT /gene="ML0144" FT /product="putative group II intron maturase-related FT protein" FT /note="Similar to many e.g. Cryphonectria parasitica FT (Chesnut blight fungus) putative maturase TR:AAF27656 FT (EMBL:AF218567) (778 aa) fasta scores: E(): 7.8e-11, 29.2% FT id in 216 aa" FT stem_loop complement(205716..205769) FT CDS complement(206601..206740) FT /pseudo FT /transl_table=11 FT /gene="ML0145" FT /note="Similar to Pseudomonas putida transposase tnpa1 FT TR:Q9R9U9 (EMBL:AJ245436) (355 aa) fasta scores: E(): FT 3.4e-05, 47.8% id in 46 aa, and to Agrobacterium FT tumefaciens transposase TR:Q44454 (EMBL:Z18270) (366 aa) FT fasta scores: E(): 0.00026, 41.3% id in 46 aa" FT repeat_region complement(207086..207280) FT /note="195 bp sequence found at 5'-end of copies 1 and 3 of FT LEPREP" FT CDS complement(207844..207954) FT /pseudo FT /transl_table=11 FT /gene="ML0146" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0941c (Best blastx score 108)" FT repeat_region 208823..208975 FT /note="153 bp repeat, 95% identical to region FT 2409794..2409946" FT misc_feature 208911..209192 FT /note="Pfam match to entry PF00934 PE, PE family, score FT 116.70, E-value 4.4e-31" FT CDS 208911..209279 FT /pseudo FT /transl_table=11 FT /gene="ML0147" FT CDS 209823..210314 FT /pseudo FT /transl_table=11 FT /gene="ML0148" FT /product="possible formamidopyrimidine-DNA glycosylase FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0944 (Best blastx score 261)" FT CDS 210338..211058 FT /pseudo FT /transl_table=11 FT /gene="ML0149" FT /product="ketoacyl reductase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0945 (Best blastx score 196)" FT CDS complement(211150..212814) FT /transl_table=11 FT /gene="pgi" FT /gene_synonym="ML0150" FT /product="glucose-6-phosphate isomerase" FT /EC_number="5.3.1.9" FT /note="Similar to M. tuberculosis Rv0946c, pgi, FT glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 FT aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap FT and Mycobacterium smegmatis pgi, glucose-6-phosphate FT isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score FT E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam FT match to entry PF00342 PGI, Phosphoglucose isomerase. FT Contains PS00765 Phosphoglucose isomerase signature 1. FT Contains PS00174 Phosphoglucose isomerase signature 2." FT /db_xref="GOA:Q9CD75" FT /db_xref="HSSP:1GZD" FT /db_xref="InterPro:IPR018189" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD75" FT /protein_id="CAC29658.1" FT /translation="MTSMQAIPDITATPAWDALRRHHDEIGATHLRQFFADNPNRGREL FT VITVGDLYIDYSKHRITHDTVQLLVDLARAANLEQRRDQMLAGVHVNTSENRSVLHTAL FT RLPRDTELIVDGQNVVQDVHAVLDVMGDFTDRLRSGEWTGATGKRINTVVNIGIGGSDL FT GPVMVYQALRHYADAGISARFVSNIDPADLTAKLSDLEPGTTLFIVASKTFSTLETLTN FT ATAARRWLTDALGEAAVSKHFVAVSTNKRLVKDFGINTANMFGFWEWVGGRYSVDSAIG FT LSLMAVVGRESFADFLSGFHIVDQHFQNAPLESNAPVLLGLIGLWYSDFLGAQSRAVLP FT YSNDLARFAAYLQQLTMESNGKSTRADGTPVTTNTGEIYWGETGTNGQHAFYQLLHQGT FT RLVPADFIGFSQPIDDLPTVDGIGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEGTPAEV FT VPHKVMPGNRPTTSILANRLTPSVLGQLIALYEHQVFTEGVIWGIDSFDQWGVELGKKQ FT AEALLPVITGNASPAQQLDSSTDTLVRRYRTERGRTS" FT misc_feature complement(211186..212652) FT /note="Pfam match to entry PF00342 PGI, Phosphoglucose FT isomerase, score 794.70, E-value 3.5e-235" FT misc_feature complement(211270..211323) FT /note="PS00174 Phosphoglucose isomerase signature 2" FT misc_feature complement(211972..212013) FT /note="PS00765 Phosphoglucose isomerase signature 1" FT CDS complement(213175..213492) FT /transl_table=11 FT /gene="ML0151" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0948c, hypothetical FT protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): FT 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to FT Streptomyces coelicolor SCD63.16C, hypothetical protein, FT TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): FT 3.9e-06, 44.4% identity in 72 aa overlap." FT /db_xref="GOA:Q9CD74" FT /db_xref="InterPro:IPR010958" FT /db_xref="UniProtKB/TrEMBL:Q9CD74" FT /protein_id="CAC29659.1" FT /translation="MRPEPPHHENAELTEMNTEVVEAPLLTDIEELREEIDRLDAQILA FT TVKRRAEVSQAIGKVRMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLG FT H" FT RBS complement(213504..213507) FT /note="possible RBS" FT CDS 214001..214189 FT /transl_table=11 FT /gene="ML0152" FT /product="hypothetical protein" FT /note="Improbable CDS suggested by GC frameplot. Possibly FT the remains of a disrupted gene." FT /db_xref="UniProtKB/TrEMBL:Q9CD73" FT /protein_id="CAC29660.1" FT /translation="MRLHKFNLDNNIGIVRKHMTGVQQQHMAQANRSTDQGNNAMAGCL FT ADCPGAFSERSASFTLG" FT CDS 214272..216608 FT /transl_table=11 FT /gene="uvrD" FT /gene_synonym="ML0153" FT /product="putative ATP-dependent DNA helicase" FT /note="Similar to M. tuberculosis Rv0949, uvrD, putative FT DNA-dependent ATPase I and helicase II, TR:P71561 FT (EMBL:AL123456) (771 aa); Fasta score E(): 0, 81.4% FT identity in 780 aa overlap. Similar to many DNA helicases FT e.g. Bacillus stearothermophilus pcrA, ATP-dependent FT helicase, SW:PCRA_BACST (P56255) (724 aa); Fasta score E(): FT 0, 43.8% identity in 774 aa overlap. Contains Pfam match to FT entry PF00580 UvrD-helicase, UvrD/REP helicase. Contains FT PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="Similar to ML0637" FT /db_xref="GOA:Q9CD72" FT /db_xref="HSSP:2PJR" FT /db_xref="InterPro:IPR014016" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD72" FT /protein_id="CAC29661.1" FT /translation="MSVHTTDAKPDSEVDRLLDGLNPQQRQAVVHEGSPLLIVAGAGSG FT KTTVLARRIAYLIAARSVGVSQILAITFTNKAAAEMRERVARLVGDHTGPSMWVSTFHS FT TCVRILRNQASLIGGLNSNFSIYDVDDSRSLLQMIGQDMGLDIKRYSPRLMANAISNLK FT NELIDAESAVANLSSDTDDLARTVATVYGEYQRRLRTANALDFDDLIGETVGILQAFPQ FT IAEHYRRRFRHVLVDEYQDTNHAQYVLVRELVGHGARNSPDDMPPGELCVVGDADQSIY FT AFRGSTISNIEDFERDYPDTTTILLEQNYRSTQNILSAANSVIARNFGRRDKRLWTDAG FT KGELIVGYVSDNEHDEAKFIADEIDALVGGGEITYDDVAVLYRANNLSRSLEEVFIPTG FT IPYKVVGGFCFYESKEIRDLIAYLRVLDNPGDAVSMRRILNTPRRGIGDRAEACVSVYA FT ENTGTSFADALQAVAEGKVPMLNTRSVKAIAGFVALLDDLRCRVDDDLGELVESVLERS FT GYLRELESSTDPQELARLDNLNELVSFAHEFSTEQANAAALAKSLHTPEDEDVPDTGAL FT AAFLEKVSLMSDTDQIPENNSGVVTLMTLHAAKGLEFPVVFVTGWEDGMLPHMRTLGDP FT TELSEERRLAYVGITRARQRLYLSRAITRSSWGQPILNPESRFLREIPPELIDWRRSIL FT TDSYSTPASGASRFGRVRPSSIRSGASKRALLVLAPGDRVTHDKYGLGRVEEVSGVGES FT AISLIDFGSSGRIKLMHNHAPVTKL" FT misc_feature 214335..215804 FT /note="Pfam match to entry PF00580 UvrD-helicase, UvrD/REP FT helicase, score 416.10, E-value 3.4e-121" FT misc_feature 214389..214412 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(217160..218161) FT /transl_table=11 FT /gene="ML0154" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0950c, hypothetical FT protein, TR:P71560 (EMBL:AL123456) (332 aa); Fasta score FT E(): 0, 71.0% identity in 331 aa overlap. Shows weaker FT similarity to many bacterial hypothetical proteins which FT contains a Peptidase family M23/M37 domain. Previously FT sequenced as TR:Q9Z5H9 (EMBL:AL035500) (343 aa); Fasta FT score E(): 0, 100.0% identity in 333 aa overlap. Contains FT Pfam match to entry PF01551 Peptidase_M37, Peptidase family FT M23/M37." FT /db_xref="GOA:Q9CD71" FT /db_xref="InterPro:IPR002886" FT /db_xref="UniProtKB/TrEMBL:Q9CD71" FT /protein_id="CAC29662.1" FT /translation="MAAEAVRSFRNRWLNHQRNDVTEIIPVDGFDDFDDLYDLDFAEID FT ELQFSDDDYNFCNETQVLLASEIDDLQDIDSLASEPLAASANVAPNFTSAPRRPCQHRK FT QPTSATRGRLLISAMAAGAMATAAHTVISHDDIPKTETVLTANASALSGATVSDATQGV FT QVITVHPAASTAVHNEEHAKGTAFAHERAQREARLSQPLYVMPTKGIFTSNFGYRWGVL FT HAGIDLANAIGTPILAVSDGVVIDVGPTAGYGMWVKLRHADGTVTLYGHVNTTLVNVGQ FT YVVAGDQIATMGTRGNSTGPHLHFEVLLSGSERIDPVPWLAKRGIYVGNYTG" FT misc_feature complement(217202..217453) FT /note="Pfam match to entry PF01551 Peptidase_M37, Peptidase FT family M23/M37, score 144.20, E-value 2.2e-39" FT CDS 218458..219639 FT /transl_table=11 FT /gene="sucC" FT /gene_synonym="ML0155" FT /product="succinyl-CoA synthase [beta] chain" FT /EC_number="6.2.1.5" FT /note="Similar to M. tuberculosis Rv0951, sucC, putative FT succinyl-CoA synthase [beta] chain, SW:SUCC_MYCTU (P71559) FT (387 aa); Fasta score E(): 0, 86.7% identity in 391 aa FT overlap. Similar to many e.g. Thermus aquaticus sucC, FT succinyl-CoA synthase [beta] chain, SW:SUCC_THEFL (P25126) FT (378 aa); Fasta score E(): 0, 48.7% identity in 384 aa FT overlap. Previously sequenced as TR:Q9Z5H8 (EMBL:AL035500) FT (393 aa); Fasta score E(): 0, 100.0% identity in 393 aa FT overlap. Contains Pfam match to entry PF00549 ligase-CoA, FT CoA-ligases. Contains Pfam match to entry PF02222 FT ATP-grasp, ATP-grasp domain. Contains PS01217 ATP-citrate FT lyase / succinyl-CoA ligases family signature 3." FT /db_xref="GOA:Q9Z5H8" FT /db_xref="HSSP:1JKJ" FT /db_xref="InterPro:IPR016102" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z5H8" FT /protein_id="CAC29663.1" FT /translation="MDLFEYQAKELFAKHGVPGIQGRVTDSAEGAKTIAMEIGRPVMVK FT AQVKTGGRGKAGGVKYAATPEEAYQQAKNILGLDIKGHIVKKLLVVEASDIAEEYYLSF FT LLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVSVDAVKGVDLACARSIAQQGHLPA FT EVLDAAAATIAKLWELFVAEDATLVEVNPLVRTPSRGYGSSGKILALDGKVTLDANARF FT RQPGHAEFEDRAATDPLEWKAKQHNLNYIKLDGEVGIIGNGAGLTMSTFDVVAYAGEQH FT GGVKPANFLDIGGGASAEVMAASLDVVLGDVQVKSVFVNIFGGITTCDTVATGIVKALE FT ILGDEANKPLVVRLDGNNVGEGRRILAEANHPLVMLVPTMDEAANKAAELART" FT misc_feature 218542..219027 FT /note="Pfam match to entry PF02222 ATP-grasp, ATP-grasp FT domain, score 164.40, E-value 1.9e-45" FT misc_feature 219187..219564 FT /note="Pfam match to entry PF00549 ligase-CoA, CoA-ligases, FT score 129.00, E-value 6.8e-35" FT misc_feature 219220..219294 FT /note="PS01217 ATP-citrate lyase / succinyl-CoA ligases FT family signature 3" FT RBS 219639..219644 FT /note="possible RBS" FT CDS 219659..220561 FT /transl_table=11 FT /gene="sucD" FT /gene_synonym="ML0156" FT /product="succinyl-CoA synthase [alpha] chain" FT /EC_number="6.2.1.5" FT /note="Similar to M. tuberculosis Rv0952, sucD, putative FT succinyl-CoA synthase [alpha] chain, SW:SUCD_MYCTU (P71558) FT (303 aa); Fasta score E(): 0, 86.3% identity in 300 aa FT overlap. Similar to many e.g. Escherichia coli sucD, FT succinyl-CoA synthase [alpha] chain, SW:SUCD_ECOLI (P07459) FT (288 aa); Fasta score E(): 0, 50.3% identity in 298 aa FT overlap. Previously sequenced as TR:Q9S372 (EMBL:AL035500) FT (300 aa); Fasta score E(): 0, 100.0% identity in 300 aa FT overlap. Contains Pfam match to entry PF00549 ligase-CoA, FT CoA-ligases. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop). Contains PS00399 ATP-citrate lyase / succinyl-CoA FT ligases family active site. Contains PS01216 ATP-citrate FT lyase / succinyl-CoA ligases family signature 1." FT /db_xref="GOA:Q9S372" FT /db_xref="HSSP:1JKJ" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9S372" FT /protein_id="CAC29664.1" FT /translation="MAIFLTKDNTVIVQGITGSEAAVHTARMLKAGTQIVGGVNARKAG FT TNVTHEDKHGRIITLPVFGTVAEAIENTGADVSIIFVPPRFAKEAIIEAVEAEIPLLVI FT ITEGIPVQDSVYAWAYNLNKGTKTRIIGPNCPGIITPGQSLVGITPATITGAGPIGLVS FT KSGTLTYQMMFELSDFGFSTAIGIGGDPVIGTTHIDAIEAFEQDPDTKIIVMIGEIGGD FT AEERAADYIKANVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAVKKDALEAAGVK FT VGKTPSETAVLVREILCTL" FT misc_feature 220088..220525 FT /note="Pfam match to entry PF00549 ligase-CoA, CoA-ligases, FT score 115.90, E-value 3.2e-31" FT misc_feature 220145..220228 FT /note="PS01216 ATP-citrate lyase / succinyl-CoA ligases FT family signature 1" FT misc_feature 220391..220432 FT /note="PS00399 ATP-citrate lyase / succinyl-CoA ligases FT family active site" FT misc_feature 220490..220513 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(220591..221452) FT /pseudo FT /transl_table=11 FT /gene="ML0157" FT /product="similar to alkanal monooxygenase beta chains FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0953c (Best blastx score 518)" FT CDS 221657..222601 FT /transl_table=11 FT /gene="ML0158" FT /product=" 34 kDa antigen" FT /note="Similar to M. tuberculosis Rv0954, 34 kDa antigenic FT protein homologue, SW:34KD_MYCTU (P71556) (303 aa); Fasta FT score E(): 0, 55.8% identity in 312 aa overlap and to FT Mycobacterium paratuberculosis 34 kDa antigenic protein, FT SW:34KD_MYCPA (Q04959) (298 aa); Fasta score E(): 0, 61.7% FT identity in 311 aa overlap. Previously sequenced as FT TR:O87894 (EMBL:U82111) (336 aa); Fasta score E(): 0, 99.7% FT identity in 314 aa overlap. Contains hydrophobic, FT membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9CD70" FT /protein_id="CAC29666.1" FT /translation="MHCSSGAVTALEITGGVMTYLPGSPGYPLVQPAGSYPGATPSFVK FT SDVGESQLYHYLTIAVVVLGLAVYLGNFGPTFTSSSDIGPGSGGFAGDAGTAVVVALLA FT ALLAGLDLLPKAKSSAGVVGAIAVLGALLAISEMINMPAGFSIGWAMWFILVCSVLQAI FT AAVAALLLEAGIITAPAPRLSYDPYLQYGQYGAQSYYGQPNRQLQVGLNAHSPQQSPAG FT YGAQYGAYTSSPTQIQAGMPATGGFSAQHSAQQGPSTPPTGFPSFSPPPSVGAAAGSQA FT GSAPVSYSNPTDSKQGFGQGRESTSSSSGSAPV" FT RBS 222637..222640 FT /note="possible RBS" FT CDS 222650..223942 FT /transl_table=11 FT /gene="ML0159" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv0955, possible membrane FT protein, SW:Y955_MYCTU (P71555) (455 aa); Fasta score E(): FT 0, 75.9% identity in 419 aa overlap. Previously sequenced FT as TR:Q9Z5H7 (EMBL:AL035500) (430 aa); Fasta score E(): 0, FT 99.8% identity in 430 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9Z5H7" FT /protein_id="CAC29667.1" FT /translation="MGDNRAAGVRQARDLVKVAFGPAVVALAIIAAITLLQLLIANSDM FT TGALGAIASMWLGVHQVPIAIGGRELSIMPLLPVLLMVWATAHSTSQATSAYSSWLVIR FT WVVASALGGPLLIAAISLAVIHDASSVLTELQTPKALRAFTGVLVVHAIGAAIGVNSRV FT GRRVLTASRLPDWVGDSVHAATAGVLALLGLSGLVTAGSLVVHWATMQEFYGITDSIFG FT QFSLTVLSVLYAPNVIVGTSAVAVGSSAHLGFATFSSFTVFGGDIPALPVLAAAPTPPL FT APVWVALLIVGAASGVAVGQQCTRHPLPLLAALAKLLVAAATGALMMALLGYAGSGRLG FT NFGDIDVDQGALVVGVFFWFAVVGWVTVVVACGIKRFPRHLKPPPALSSEEHADASSKD FT HEAYFGVDLNVPFDLSGEDEIPKAEPGEAAD" FT CDS 223972..224619 FT /transl_table=11 FT /gene="purN" FT /gene_synonym="ML0160" FT /product="putative phosphoribosylglycinamide FT formyltransferase" FT /EC_number="2.1.2.2" FT /note="Similar to M. tuberculosis Rv0956, purN, putative FT phosphoribosylglycinamide formyltransferase, TR:P71554 FT (EMBL:AL123456) (215 aa); Fasta score E(): 0, 79.4% FT identity in 214 aa overlap. Similar to many e.g. FT Mycobacterium avium subsp. paratuberculosis purN, FT phosphoribosylglycinamide formyltransferase I, TR:Q9RAJ6 FT (EMBL:AF191543) (209 aa); Fasta score E(): 0, 81.6% FT identity in 207 aa overlap. Previously sequenced as FT TR:Q9Z5H6 (EMBL:AL035500) (215 aa); Fasta score E(): 0, FT 99.5% identity in 215 aa overlap. Contains Pfam match to FT entry PF00551 formyl_transf, Formyl transferase." FT /db_xref="GOA:Q9Z5H6" FT /db_xref="HSSP:1GAR" FT /db_xref="InterPro:IPR004607" FT /db_xref="UniProtKB/TrEMBL:Q9Z5H6" FT /protein_id="CAC29668.1" FT /translation="MQEPLCVSPSAPSRVVVLASGTGSLLGSLIDASVGNYPARVVAVG FT VDRDCGATKIAKAASVPTFTVRLADPPGRDAWDAKITEAVASYKPDLVVLAGFMRILGP FT QFLARFFGRIVNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILAQQS FT VPVLDGDDTAALHERIKVIERRLLVDVVAVIATGGVTLVGRKATIGRKATIE" FT misc_feature 224008..224544 FT /note="Pfam match to entry PF00551 formyl_transf, Formyl FT transferase, score 156.30, E-value 6.8e-44" FT CDS 224616..226199 FT /transl_table=11 FT /gene="purH" FT /gene_synonym="ML0161" FT /product="putative phosphoribosylaminoimidazolecarboxamide FT formyltransferase / IMP cyclohydrolase" FT /EC_number="2.1.2.3" FT /EC_number="3.5.4.10" FT /note="Similar to M. tuberculosis Rv0957, purH, putative FT phosphoribosylaminoimidazolecarboxamide formyltransferase / FT IMP cyclohydrolase, SW:PUR9_MYCTU (P71553) (523 aa); Fasta FT score E(): 0, 88.1% identity in 520 aa overlap. Similar to FT many e.g. Bacillus subtilis purN, FT phosphoribosylaminoimidazolecarboxamide formyltransferase / FT IMP cyclohydrolase, SW:PUR9_BACSU (P12048) (512 aa); Fasta FT score E(): 0, 43.2% identity in 519 aa overlap. Previously FT sequenced as SW:PUR9_MYCLE (Q9Z5H5) (527 aa); Fasta score FT E(): 0, 100.0% identity in 527 aa overlap. Contains Pfam FT match to entry PF01808 AICARFT_IMPCHas, AICARFT/IMPCHase FT bienzyme." FT /db_xref="GOA:Q9Z5H5" FT /db_xref="HSSP:1G8M" FT /db_xref="InterPro:IPR011607" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z5H5" FT /protein_id="CAC29669.1" FT /translation="MSSDGERDMARKPIRRALISVYDKTGLIDLAQGLNAAGVDIVSTG FT STAKAIADQGIAVTPVEELTGFPEVLDGRVKTLHPRVHAGLLADLRKPEHAAALEQLGI FT EAFELVVVNLYPFSQTVKSGATVDECVEQIDIGGSSMVRAAAKNHPSVAVVTDPLGYVG FT VLAAVQGGGFTLAERKMLASMAFQHIAEYEIAVASWMQSTLAPEQPPTAFPQWFGRSWR FT RSAILRYGENPHQQAALYSDPSACPGLAQAEQLHGKNMSYNNFTDADAAWRAAFDHEQS FT CVAIIKHANPCGIAISSLSVADAHRKAHECDPLSAYGGVIAANTEVSLEMAEYVSTIFT FT EVIVAPSYAPGAVDVLSCKKNVRVLVASAPLRGGSELRPVSGGLLIQQPDQLDTAGDNP FT ANWTLATGSPAGPATLTDLVFAWRACRAVKSNAIVIAADGATIGVGMGQVNRVDAARLA FT VERGGDRVRGAVVASDAFFPFADGLQTLAAAGVTAIVHPGGSVRDAEVTAAATKAGVTL FT YLTGVRHFVH" FT misc_feature 225048..225992 FT /note="Pfam match to entry PF01808 AICARFT_IMPCHas, FT AICARFT/IMPCHase bienzyme, score 585.50, E-value 3.2e-172" FT CDS complement(227008..227286) FT /transl_table=11 FT /gene="ML0162" FT /product="hypothetical protein" FT /note="Improbable CDS suggested by GC frameplot. Possibly FT the remains of a disrupted gene. Previously sequenced as FT TR:Q9Z5H3 (EMBL:AL035500) (92 aa); Fasta score E(): 0, FT 98.9% identity in 92 aa overlap." FT /db_xref="InterPro:IPR001969" FT /db_xref="UniProtKB/TrEMBL:Q9Z5H3" FT /protein_id="CAC29670.1" FT /translation="MVVRPTKLIVRINCDQHSDWTMLDFRHRCNNLADQIGNGSSSRAP FT SLGNPHTAVPNVMADTGTALLRLLHDLFLRMHHDQSGNHSDQKHVPL" FT CDS 228661..229628 FT /pseudo FT /transl_table=11 FT /gene="ML0163" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0959 (Best blastx score 266)" FT CDS 229629..230493 FT /pseudo FT /transl_table=11 FT /gene="fadE13" FT /gene_synonym="ML0164" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE13 (Best blastx score 280)" FT CDS 230546..231663 FT /pseudo FT /transl_table=11 FT /gene="accD2" FT /gene_synonym="ML0165" FT /product="acetyl/propionyl-CoA carboxylase, [beta] subunit FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT accD2 (Best blastx score 451)" FT CDS 231672..233398 FT /pseudo FT /transl_table=11 FT /gene="accA2" FT /gene_synonym="ML0166" FT /product="acetyl/propionyl-CoA carboxylase, [alpha] subunit FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT accA2 (Best blastx score 317)" FT CDS 233449..234077 FT /pseudo FT /transl_table=11 FT /gene="fadE12" FT /gene_synonym="ML0167" FT /product="acyl-CoA dehydrogenase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT fadE12 (Best blastx score 396)" FT CDS 234124..234820 FT /pseudo FT /transl_table=11 FT /gene="echA7" FT /gene_synonym="ML0168" FT /product="enoyl-CoA hydratase/isomerase superfamily FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT echA7 (Best blastx score 174)" FT CDS 234932..235534 FT /transl_table=11 FT /gene="ML0169" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0966c, hypothetical FT protein, SW:Y966_MYCTU (P71544) (230 aa); Fasta score E(): FT 0, 79.5% identity in 200 aa overlap. Also similar to FT Streptomyces coelicolor SCE6.30C, hypothetical protein, FT TR:CAB88834 (EMBL:AL353832) (277 aa); Fasta score E(): FT 3.3e-20, 41.0% identity in 205 aa overlap. Previously FT sequenced as TR:Q9Z5H1 (EMBL:AL035500) (200 aa); Fasta FT score E(): 0, 100.0% identity in 200 aa overlap." FT /db_xref="InterPro:IPR012551" FT /db_xref="UniProtKB/TrEMBL:Q9Z5H1" FT /protein_id="CAC29677.1" FT /translation="MSNSAQRDAKGARDEPLRAADTDRIQIAQLLAYAAEQGRLELKDY FT EDRLAKAYAATTYQELEQLRDDLPGSQVSARRGGNPNPAPSTLLLALMSGFERRGRWNV FT PRKLTTFSLWGSGVLDLRYADFTSTEVELHAYSVMGVQTILLPPEVNVEISGHGVMGSF FT DRQVRGQGTPGAPTVKIRGFSLWGGVGIKRKARRPRR" FT CDS 235667..235822 FT /pseudo FT /transl_table=11 FT /gene="ML0170" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0965c (Best blastx score 115)" FT CDS 236614..237352 FT /pseudo FT /transl_table=11 FT /gene="ML0171" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0963c (Best blastx score 311)" FT CDS 237609..238202 FT /pseudo FT /transl_table=11 FT /gene="ML0172" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0962c (Best blastx score 310)" FT repeat_region 238509..238529 FT /note="21 bp repeat found at 5'-ends of REPLEP copies 1, 2, FT 6 & 11. " FT repeat_region 238509..239454 FT /note="REPLEP region 1, 3'-end most similar to REPLEP 4, 5 FT and 6" FT repeat_region 238530..239409 FT /note="Dispersed repeat, REPLEP, copy 1, shows 55% ID to FT self on complement" FT repeat_region 239410..239454 FT /note="45 bp REPLEP-associated sequence" FT CDS 240237..240410 FT /transl_table=11 FT /gene="rpmF" FT /gene_synonym="ML0173" FT /note="probable ribosomal protein L32, rpmF,similar to many FT e.g. tr|Q9RL50|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN (56 FT aa) E(): 1.5e-09; 63.462% identity in 52 aa overlap" FT /db_xref="GOA:Q9CD69" FT /db_xref="InterPro:IPR002677" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD69" FT /protein_id="CAC29681.1" FT /translation="MATPKRRMSRANTRSRRAQWKAARTELVGVTVAGQRHKVPRRLLK FT AARLGLIDLDRR" FT misc_feature 240531..240866 FT /note="Pfam match to entry PF00072 response_reg, Response FT regulator receiver domain, score 158.60, E-value 1.1e-43" FT CDS 240531..241217 FT /transl_table=11 FT /gene="ML0174" FT /product="putative two-component response regulator" FT /note="Similar to several putative two-component response FT regulators from M. tuberculosis e.g. Rv0981, putative FT two-component response regulator, TR:O53894 (EMBL:AL123456) FT (230 aa); Fasta score E(): 0, 94.3% identity in 228 aa FT overlap. Similar to many others e.g. Pseudomonas syringae FT copR, transcriptional activator protein involved in FT activation of copper resistance, SW:COPR_PSESM (Q02540) FT (227 aa); Fasta score E(): 6.4e-32, 43.9% identity in 223 FT aa overlap. Previously sequenced as TR:Q9Z5G8 FT (EMBL:AL035500) (253 aa); Fasta score E(): 0, 100.0% FT identity in 228 aa overlap. Contains Pfam match to entry FT PF00486 trans_reg_C, Transcriptional regulatory protein, C FT terminal. Contains Pfam match to entry PF00072 FT response_reg, Response regulator receiver domain." FT /note="Similar to ML0773, ML1286, ML2123 and ML2439" FT /db_xref="GOA:Q9CD68" FT /db_xref="HSSP:1B00" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD68" FT /protein_id="CAC29682.1" FT /translation="MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRP FT DALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFA FT LEELLARIRALLRRTKPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEM FT LIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYV FT LRETPP" FT misc_feature 240975..241190 FT /note="Pfam match to entry PF00486 trans_reg_C, FT Transcriptional regulatory protein, C terminal, score FT 85.90, E-value 2.2e-24" FT RBS 241199..241205 FT /note="possible RBS" FT CDS 241217..242776 FT /transl_table=11 FT /gene="ML0175" FT /product="putative two-component system sensor kinase" FT /note="Similar to several putative two-component system FT sensor kinases from M. tuberculosis e.g. Rv0982, putative FT two-component system sensor kinase, TR:O53895 FT (EMBL:AL123456) (504 aa); Fasta score E(): 0, 81.0% FT identity in 521 aa overlap. Similar to many others e.g. FT Pseudomonas syringae copS, sensor protein involved in FT activation of copper resistance, SW:COPS_PSESM (Q02541) FT (487 aa); Fasta score E(): 1.2e-18, 27.9% identity in 427 FT aa overlap. Previously sequenced as TR:Q9Z5G7 FT (EMBL:AL035500) (519 aa); Fasta score E(): 0, 100.0% FT identity in 519 aa overlap. Contains hydrophobic, possible FT membrane-spanning regions. Contains Pfam match to entry FT PF00672 DUF5, Domain found in bacterial signal proteins. FT Contains Pfam match to entry PF00512 signal, Histidine FT kinase. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /note="Similar to ML0774, ML2124 and ML2440" FT /db_xref="GOA:Q9Z5G7" FT /db_xref="HSSP:1BXD" FT /db_xref="InterPro:IPR005467" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z5G7" FT /protein_id="CAC29683.1" FT /translation="MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYV FT VISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGHSIYTANQ FT PGQTLPVGTAEKAVIRGELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMTKLR FT WVLLIVGSLGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARL FT TEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEM FT ADLRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPIDMSEVLYRSLERVRRRRNDIHF FT DVQAIGWQIYGDAAGLSRAVLNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPG FT IPPQERRLVFERFYRSTTARSLPGSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSI FT YVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSAR FT AR" FT misc_feature 241712..241921 FT /note="Pfam match to entry PF00672 DUF5, Domain found in FT bacterial signal proteins, score 65.20, E-value 1.4e-15" FT misc_feature 241961..242605 FT /note="Pfam match to entry PF00512 signal, Histidine FT kinase, score 137.60, E-value 2.2e-37" FT misc_feature 242690..242713 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 243054..244202 FT /transl_table=11 FT /gene="ML0176" FT /product="possible secreted serine protease" FT /note="Similar to M.tuberculosis Rv0983, probable serine FT protease, TR:O53896 (EMBL:AL123456) (464 aa); Fasta score FT E(): 0, 80.7% identity in 383 aa overlap and in part to FT M.tuberculosis htrA, putative serine protease, TR:O06291 FT (EMBL:AL123456) (549 aa); Fasta score E(): 0, 41.8% FT identity in 347 aa overlap. Similar to many e.g. putative FT serine protease expressed in vivo by Mycobacterium avium FT subsp. paratuberculosis, TR:Q50320 (EMBL:Z23092) (361 aa); FT Fasta score E(): 1.1e-19, 35.4% identity in 362 aa overlap. FT Previously sequenced as TR:Q9Z5G6 (EMBL:AL035500) (452 aa); FT Fasta score E(): 0, 100.0% identity in 382 aa overlap. FT Contains a possible N-terminal signal sequence. Contains FT Pfam match to entry PF00595 PDZ, PDZ domain (Also known as FT DHR or GLGF).. Contains Pfam match to entry PF00089 FT trypsin, Trypsin." FT /note="Similar to ML1078 and ML2659" FT /db_xref="GOA:Q9CD67" FT /db_xref="HSSP:1LCY" FT /db_xref="InterPro:IPR001254" FT /db_xref="UniProtKB/TrEMBL:Q9CD67" FT /protein_id="CAC29684.1" FT /translation="MIPPGRVADRRPRAGMLAVSALAIAVVSAGIGGVAATVVALGTRV FT AGGNGAGPVTGPAASVPAANMPSGSVEQVAVKVVPSVVMLETDLGRQSEEGSGVILSAD FT GLILTNNHVVAVAAKPGGGPGGGLSPKTTVTFFDGRTASFTVVGADPTSDIAVVRVQSI FT SGLTPITMGSSADLRVGQPVVAVGSPLGLAGTVTSGIVSALNRPVSTTGESGNQNTVLD FT AIQTDAAINPGNSGGALVNMGGQLVGVNSAIATLGADSGDAQSGSIGLGFAIPVDQAKR FT IADELISTGKATHASLGVQVATDKGTPGAKVMDVVAGGAAANAAVPKGVVLTKVDDRLI FT SSADALVAAVRSKAPGDKVSLTYQDQSGSSRTVQVTLGKAEQ" FT misc_feature 243342..243899 FT /note="Pfam match to entry PF00089 trypsin, Trypsin, score FT 50.90, E-value 2.7e-15" FT misc_feature 243909..244151 FT /note="Pfam match to entry PF00595 PDZ, PDZ domain (Also FT known as DHR or GLGF)., score 16.80, E-value 0.025" FT CDS 244225..244770 FT /transl_table=11 FT /gene="moaB" FT /gene_synonym="ML0177" FT /product="putative molybdenum cofactor biosynthesis FT protein" FT /note="Similar to M.tuberculosis moaB2, putative molybdenum FT cofactor biosynthesis protein, TR:O53897 (EMBL:AL123456) FT (181 aa); Fasta score E(): 0, 92.7% identity in 179 aa FT overlap. Similar to many e.g. to the C-terminal halves of FT Arabidopsis thaliana cnx1, multifunctional two-domain FT protein involved in molybdenum cofactor biosynthesis, FT SW:CNX1_ARATH (Q39054) (670 aa); Fasta score E(): 7.7e-10, FT 36.4% identity in 187 aa overlap and Synechococcus sp. FT (strain PCC 7942) moaCB, molybdenum cofactor biosynthesis FT protein, SW:MOCB_SYNP7 (Q56208) (319 aa); Fasta score E(): FT 1.3e-09, 35.9% identity in 142 aa overlap. Previously FT sequenced as TR:Q9Z5G5 (EMBL:AL035500) (181 aa); Fasta FT score E(): 0, 99.4% identity in 181 aa overlap." FT /db_xref="GOA:Q9Z5G5" FT /db_xref="HSSP:1O8Q" FT /db_xref="InterPro:IPR001453" FT /db_xref="UniProtKB/TrEMBL:Q9Z5G5" FT /protein_id="CAC29685.1" FT /translation="MLVDKQLSELGYTVAPMEKGVELVVGRALIVVVDDRTAHGDEDHS FT GPLVTELLTEAGFVVDGVVAVAADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRDVAPE FT ATREILDREILGIAEAIRASGLSAGITDAGLSRGLAGVSGSTLVVNLAGSRYAVRDGMA FT TLNPLATQIIGQLSSLEI" FT CDS complement(244787..245251) FT /transl_table=11 FT /gene="mscL" FT /gene_synonym="ML0178" FT /product="putative mechanosensitive channel protein" FT /note="Similar to M.tuberculosis mscL, Rv0985c, putative FT mechanosensitive channel protein, SW:MSCL_MYCTU (O53898) FT (151 aa); Fasta score E(): 0, 71.0% identity in 155 aa FT overlap. Similar to many e.g. Escherichia coli mscL, FT large-conductance mechanosensitive channel, SW:MSCL_ECOLI FT (P23867) (136 aa); Fasta score E(): 1.3e-07, 32.1% identity FT in 134 aa overlap. Previously sequenced as SW:MSCL_MYCLE FT (Q9Z5G4) (154 aa); Fasta score E(): 0, 100.0% identity in FT 154 aa overlap. Contains hydrophobic, possible FT membrane-spanning regions. Contains Pfam match to entry FT PF01741 MscL, Large-conductance mechanosensitive channel, FT MscL. Contains PS01327 Large-conductance mechanosensitive FT channels mscL family signature." FT /db_xref="GOA:Q9Z5G4" FT /db_xref="HSSP:1MSL" FT /db_xref="InterPro:IPR001185" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z5G4" FT /protein_id="CAC29686.1" FT /translation="MFRGFKEFLSRGNIVDLAVAVVIGTAFTALITKFTDSIITPLINR FT VGVNQQTNISPLRIDIGGDQAIDLNIVLSAAINFLLIALVVYFLVVLPYTTIRKHGEVE FT QFDTDLIGNQVVLLAEIRDLLAQSNGAPSGRHVDTADLTPTPNHEPRADT" FT misc_feature complement(244868..245191) FT /note="Pfam match to entry PF01741 MscL, Large-conductance FT mechanosensitive channel, MscL, score 91.50, E-value FT 1.6e-23" FT misc_feature complement(245180..245221) FT /note="PS01327 Large-conductance mechanosensitive channels FT mscL family signature" FT RBS complement(245258..245263) FT /note="possible RBS" FT CDS complement(245324..245983) FT /pseudo FT /transl_table=11 FT /gene="ML0179" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0990c (Best blastx score 338)" FT CDS complement(246049..246348) FT /transl_table=11 FT /gene="ML0180" FT /product="conserved hypothetical protein. Ser-rich FT C-terminus" FT /note="Similar to M.tuberculosis Rv0991c, hypothetical FT protein with Ser-rich C-terminus, TR:O05574 (EMBL:AL123456) FT (110 aa); Fasta score E(): 1.1e-23, 78.5% identity in 93 aa FT overlap. Similar to other bacterial Ser-rich hypothetical FT proteins e.g. Streptomyces coelicolor SCE22.04, FT hypothetical protein, TR:CAB90971 (EMBL:AL355832) (110 aa); FT Fasta score E(): 2.6e-15, 54.5% identity in 99 aa overlap. FT Previously sequenced as TR:Q9Z5G3 (EMBL:AL035500) (120 aa); FT Fasta score E(): 1.1e-32, 100.0% identity in 99 aa FT overlap." FT /db_xref="InterPro:IPR013429" FT /db_xref="UniProtKB/TrEMBL:Q9CD66" FT /protein_id="CAC29688.1" FT /translation="MPTYSYECTECTNRFDVVQAFTDDALTTCEKCSGRLRKLFNSVGV FT VFKGSGFYRTDSRESGEKSNSSSNGSSKSDSGSSSGSSDKSNSSSAPAVATAPS" FT RBS complement(246354..246358) FT /note="possible RBS" FT CDS complement(246423..247016) FT /transl_table=11 FT /gene="ML0181" FT /product="conserved hypothetical protein" FT /note="Similar to M.tuberculosis Rv0992c, conserved FT hypothetical protein, TR:O05575 (EMBL:AL123456) (197 aa); FT Fasta score E(): 0, 72.6% identity in 197 aa overlap. FT Similar to many hypothetical proteins and shows weak FT similarity to methenyltetrahydrofolate synthetases e.g. FT human mthfs, 5-formyltetrahydrofolate cyclo-ligase, FT SW:FTHC_HUMAN (P49914) (202 aa); Fasta score E(): 7e-06, FT 23.3% identity in 189 aa overlap. Previously sequenced as FT TR:Q9Z5G2 (EMBL:AL035500) (197 aa); Fasta score E(): 0, FT 100.0% identity in 197 aa overlap. Contains Pfam match to FT entry PF01812 5-FTHF_cyc-lig, 5-formyltetrahydrofolate FT cyclo-ligase." FT /db_xref="GOA:Q9Z5G2" FT /db_xref="InterPro:IPR002698" FT /db_xref="UniProtKB/TrEMBL:Q9Z5G2" FT /protein_id="CAC29689.1" FT /translation="MVTASKATLRKQLLAARRSVADDIRAAETKMLSQHLELLVNSAST FT VCAYVPVGTEPGAIEMLDVLLRKTGRVLLPVARTGDDEIPLPLQWGEYRPGGLTSGPWG FT LLEPPELRLPESALAEANLVLVPALAVDHHGVRLGRGGGFYDRSLAGRDPHTLLIALVR FT DTELLNELPSEPHDVRMTHAVTPERGVIALPNSE" FT misc_feature complement(246459..246971) FT /note="Pfam match to entry PF01812 5-FTHF_cyc-lig, FT 5-formyltetrahydrofolate cyclo-ligase, score 169.90, FT E-value 4.1e-47" FT RBS complement(247034..247037) FT /note="possible RBS" FT CDS 247094..248014 FT /transl_table=11 FT /gene="galU" FT /gene_synonym="ML0182" FT /product="putative UTP-glucose-1-phosphate FT uridylyltransferase" FT /EC_number="2.7.7.9" FT /note="Similar to M.tuberculosis galU, Rv0993, FT UTP-glucose-1-phosphate uridylyltransferase, TR:O05576 FT (EMBL:AL123456) (306 aa); Fasta score E(): 0, 89.7% FT identity in 302 aa overlap. Similar to many e.g. FT Escherichia coli galU, UTP--glucose-1-phosphate FT uridylyltransferase, SW:GALU_ECOLI (P25520) (301 aa); Fasta FT score E(): 5.4e-33, 38.8% identity in 299 aa overlap. FT Previously sequenced as TR:Q9Z5G1 (EMBL:AL035500) (306 aa); FT Fasta score E(): 0, 100.0% identity in 306 aa overlap. FT Contains Pfam match to entry PF00483 NTP_transferase, FT Nucleotidyl transferase." FT /db_xref="GOA:Q9Z5G1" FT /db_xref="InterPro:IPR005835" FT /db_xref="UniProtKB/TrEMBL:Q9Z5G1" FT /protein_id="CAC29690.1" FT /translation="MSLLLSAQVPIPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPG FT IELVAAEAAAAGAERLVIVTSEGKDGVVAHFVQDLVLEGTLLARGNKAMLAKVRRAPEL FT IKVESVVQAEPLGLGHAIGCAEPTLAPDEDAVSVLLPDDLVLPTGVLETMSKVRASRGG FT TVLCAIEVASEEISSYGVFDVEPVPGGDNPNVLKVIGMVEKPKAEDAPSTFAAAGRYVL FT DRAIFDALRRVSRGTGGEVQITDAIALLIKEGHPVHVVVHRGSRHDLGNPGGYLKAAVD FT FALDRDDYGPDLRRWLVERLGLIEQ" FT misc_feature 247133..247948 FT /note="Pfam match to entry PF00483 NTP_transferase, FT Nucleotidyl transferase, score 54.30, E-value 2.7e-12" FT misc_feature 248102..249361 FT /note="Pfam match to entry PF00994 MoCF_biosynth, FT Molybdenum cofactor biosynthesis protein, score 551.80, FT E-value 4.7e-162" FT CDS 248102..249376 FT /transl_table=11 FT /gene="moeA" FT /gene_synonym="ML0183" FT /product="putative molybdopterin biosynthesis protein" FT /note="Similar to M.tuberculosis moeA, Rv0994, putative FT molybdopterin biosynthesis protein, SW:MOEA_MYCTU (O05577) FT (426 aa); Fasta score E(): 0, 88.3% identity in 426 aa FT overlap. Similar to many e.g. Escherichia coli moeA, FT molybdopterin biosynthesis protein, SW:MOEA_ECOLI (P12281) FT (411 aa); Fasta score E(): 3.3e-23, 31.4% identity in 392 FT aa overlap. Previously sequenced as TR:Q9Z5G0 FT (EMBL:AL035500) (424 aa); Fasta score E(): 0, 99.8% FT identity in 424 aa overlap. Contains Pfam match to entry FT PF00994 MoCF_biosynth, Molybdenum cofactor biosynthesis FT protein." FT /db_xref="GOA:Q9Z5G0" FT /db_xref="HSSP:1G8L" FT /db_xref="InterPro:IPR005110" FT /db_xref="UniProtKB/TrEMBL:Q9Z5G0" FT /protein_id="CAC29691.1" FT /translation="MRSVEEQQARILAAAVVPRPVRVAIAEAQGLMCAEEVMTERPLPG FT FDQAAIDGYAVRSVDVSGIGESDGGESGSSDEDGRYVLTLPVMGTIEAGARTPSRLLPH FT QAVRVQTGAPLPVLADAVLPVRWTDGGMSRVRILRGAPSGAYVRRVGDDVQPGDVAVRA FT GTIIGAAQVGLLAAVGRERVLVHPRPRLSIMAVGGELVDISRTPGNGQVYDVNSYALTA FT AGRDAGAEVNRIGIVSNNLKEFGEVVEGQISRAEVVVIAGGVGGAAAEAVRAVLSEIGE FT MEVVRVAMHPGSVQGFGQLGREGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQPMR FT RIVQARTLSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGALGASSHLLATLAEANCL FT VVIPSGAEQIRTGEVVDVAFLAQRG" FT CDS 249407..250051 FT /transl_table=11 FT /gene="rimJ" FT /gene_synonym="ML0184" FT /product="possible acetyltransferase" FT /note="Similar to M.tuberculosis rimJ, Rv0995, possible FT acetyltransferase, TR:O05578 (EMBL:AL123456) (203 aa); FT Fasta score E(): 0, 86.0% identity in 200 aa overlap. FT Similar to Escherichia coli rimJ, ribosomal-protein-alanine FT acetyltransferase, SW:RIMJ_ECOLI (P09454) (194 aa); Fasta FT score E(): 9.4e-12, 28.0% identity in 189 aa overlap and to FT other putative acetyltransferases. Previously sequenced as FT TR:Q9Z5F9 (EMBL:AL035500) (218 aa); Fasta score E(): 0, FT 100.0% identity in 214 aa overlap. Contains Pfam match to FT entry PF00583 Acetyltransf, Acetyltransferase (GNAT) FT family." FT /db_xref="GOA:Q9CD65" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q9CD65" FT /protein_id="CAC29692.1" FT /translation="MRFNARHPGWPSNVGPLRVPAGVIRLRAVRLRDGVQWSRIRLADR FT AYLEPWEPSTEGDWVVRHSVIAWQVLCSSLRSEARKGRMLPYAIELDGNFCGQLTIGNV FT THGALRSAWIGYWVSSSATGGGVATGALALGLDHCFGPVMLHRVEATVRPANVASRAVL FT AKVGFREEGLLRRYLEVDRAWRDHLLMALTIEEVSGSVTSNLVRAGRASWL" FT misc_feature 249482..249913 FT /note="Pfam match to entry PF00583 Acetyltransf, FT Acetyltransferase (GNAT) family, score 16.40, E-value FT 0.027" FT RBS 250205..250210 FT /note="possible RBS" FT CDS 250221..251249 FT /transl_table=11 FT /gene="ML0185" FT /product="putative membrane protein" FT /note="Similar to M.tuberculosis Rv0996, hypothetical FT protein, TR:O05579 (EMBL:AL123456) (358 aa); Fasta score FT E(): 0, 66.4% identity in 360 aa overlap. Previously FT sequenced as TR:Q9Z5F8 (EMBL:AL035500) (342 aa); Fasta FT score E(): 0, 100.0% identity in 342 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:Q9Z5F8" FT /protein_id="CAC29693.1" FT /translation="MPSIPQSLLWISLVVLWLFVLVPMLISKRDVVRRISDVALATRVL FT NGVAGARLLKRGGPATGHRSDHNWELDEDWRQNPVDGEFADADQDIGEEQDQNVDDTQR FT TRPVVMEVAVAELTGTDYLDVDVVEDSVALPIEDSADVTESVLLAVGEGGSPGEEAEAE FT QRQSDRYGYVDASSGLGLEQKDDKSPVPVAPTVSRQRRYDTKTATAVSARKYAFRKRVL FT MVMAIILVGSAAAAFEVDSNAWWICGSSTTVTVLYLAYLRRQTRIEEKVRSRRMHRIAR FT ARVDVENAHDREFDVVPSRLRRPGAVVLEIDDEDPIFEHLDYEMPIRTFGWPRDLPRAV FT GQ" FT tRNA 251305..251377 FT /gene="alaV" FT /note="tRNA Ala anticodon CGC, Cove score 82.84" FT CDS 251982..252266 FT /pseudo FT /transl_table=11 FT /gene="ML0186" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0997 (Best blastx score 101)" FT CDS 252658..253719 FT /transl_table=11 FT /gene="ML0187" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv0998, hypothetical FT protein, TR:O05581 (EMBL:AL123456) (333 aa); Fasta score FT E(): 0, 69.7% identity in 330 aa overlap. Contains Pfam FT match to entry PF00027 cNMP_binding, Cyclic FT nucleotide-binding domain. Contains PS00889 Cyclic FT nucleotide-binding domain signature 2." FT /db_xref="GOA:Q9CD64" FT /db_xref="InterPro:IPR018488" FT /db_xref="UniProtKB/TrEMBL:Q9CD64" FT /protein_id="CAC29695.1" FT /translation="MAGSWQCGHCESCASPLGPRDIAVVELIADRAEEFAAMDIFRGLP FT AEDLMSVAVSVEPVLAAAGEVLMQQGEQAVSFLLISSGNVEVRRVDDDGAVIVGQASHG FT MIIGEIALLRDGRRTATVITTEPLTGWVGDIDAFAQMVQIPSITRRLLLTVRQRLAAFI FT TPIPVQLRDGTHLMLRPVLPGDTERSLRGHVRFSRETLYLRFMSARAPSDELMHYLSEV FT DYVDHFVWVVTDGGDPVADARFVRDESDPTLAEIAFTVADAYQGRGVGNFLISALSIAA FT HVNGVNRFSARMLTDNGPMRAIMDHHGAVWRRYDVGVITTVIDVPRQRDLIIGRAMADQ FT IAGVVRQVIGAVG" FT misc_feature 252817..253098 FT /note="Pfam match to entry PF00027 cNMP_binding, Cyclic FT nucleotide-binding domain, score 74.70, E-value 1.9e-18" FT misc_feature 252976..253029 FT /note="PS00889 Cyclic nucleotide-binding domain signature FT 2" FT CDS 254028..254291 FT /transl_table=11 FT /gene="ML0188" FT /product="hypothetical protein" FT /note="Unknown function. Contains PS01047 FT Heavy-metal-associated domain." FT /db_xref="InterPro:IPR017969" FT /db_xref="UniProtKB/TrEMBL:Q9CD63" FT /protein_id="CAC29696.1" FT /translation="MDPINSPRACPVSDAGGIVDAVAVPVVVGRYLFAACEQLTMMVRR FT TIASVHLIEATCIDCVDTLGMAVDVWISVEAGAEIDLRTYIA" FT misc_feature 254181..254273 FT /note="PS01047 Heavy-metal-associated domain" FT CDS 254397..255092 FT /pseudo FT /transl_table=11 FT /gene="ML0189" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv0999 (Best blastx score 400)" FT CDS complement(255125..255742) FT /transl_table=11 FT /gene="ML0190" FT /product="conserved hypothetical protein" FT /note="Unknown but orthologue of equivalent to new M. FT tuberculosis CDS, Rv1000. Very similar to conserved FT hypothetical proteins in various bacteria e.g. Streptomyces FT coelicolor, Xylella fastidiosa. FASTA scores: FT gp|AL357613|AL357613_12 Streptomyces coelicolor cosmid (210 FT aa) E(): 2.4e-44; 55.122% identity in 205 aa overlap; FT AE003963|AE003963_5 Xylella fastidiosa, E(): 9.7e-14; 3 FT 9.894% identity in 188 aa overlap. Weak similarity to FT proteins involved in DNA repair" FT /db_xref="UniProtKB/TrEMBL:Q9CD62" FT /protein_id="CAC29698.1" FT /translation="MCDMLVDVGIAFQGSLFEYHERRQLGDGAFIELRSGWLTDGVELL FT DTLLSEVPWRIERRRMYDKVVNVPRLVSFHDLTTDDPPHPLLTRLRRRLNDIYAGELGE FT PFTSVGLCCYRDGSDSIAWHGDTIGRNSSEDTMVAIISLGATRVFALRKRGGGPSLRLP FT LTHGDLLVMGGSCQRTWEHSVPKTSASTGPRVSIQFRPRNVH" FT CDS 255879..256895 FT /pseudo FT /transl_table=11 FT /gene="arcA" FT /gene_synonym="ML0191" FT /product="arginine deiminase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT arcA (Best blastx score 249)" FT CDS complement(257035..258567) FT /transl_table=11 FT /gene="ML0192" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv1002c, probable FT membrane protein, TR:O05586 (EMBL:AL123456) (503 aa); Fasta FT score E(): 0, 80.4% identity in 510 aa overlap. Also FT similar to Streptomyces coelicolor SCE87.05, putative FT integral membrane protein, TR:Q9RKD3 (EMBL:AL132674) (591 FT aa); Fasta score E(): 0, 36.7% identity in 531 aa overlap. FT Contains hydrophobic, possible membrane-spanning regions." FT /db_xref="GOA:Q9CD61" FT /db_xref="InterPro:IPR003342" FT /db_xref="UniProtKB/TrEMBL:Q9CD61" FT /protein_id="CAC29700.1" FT /translation="MISPGPLVPVEDFGPTDDVRGWIATGVITVLATGTRFINLSSPTD FT AGTPIFDEKHYAPQAWQLLHNHGVEDNPGFGLVVHPPIGKQLIAIGEAIFGYNGVGWRF FT TGALLGVIMVALVMRIVRRITRSTLIGTIAGLLVICDGVSFVTARTALLDGFLTFFVVA FT TFGALIVDRDQVRQRMHTAITEGRSTETVWGPRLGVRWWRFLGGILLGLACATKWSGLY FT FVLFFGVMSLAFDVSSRRQYQVLNPWRGVLRRDVIPTVYALGLISFLVYITSYAPWFAS FT ETAIDRHQVGQTIGRHGMIPLPDAVRSLWYYHAKTLQFHAGLTNSAGNYHPWESKPWSW FT PMSLRPVLYAIDQQDVPGCGAQSCVKAEMLVGTPAMWWLAVPVLVYATWRTVIQRDWRY FT AAVLVGYCAGWLPWFADIDRQMYLFYAATMAPFLVMGIALILGDILYPPWHDSSPRSPS FT THSTERRTLRLIAVSCYVALVITNFVWLYPVLTGLPISHQTWNMEIWLPSWR" FT RBS complement(258582..258586) FT /note="possible RBS" FT CDS 258646..259491 FT /transl_table=11 FT /gene="ML0193" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1003, conserved FT hypothetical protein, SW:YA03_MYCTU (O05588) (285 aa); FT Fasta score E(): 0, 74.0% identity in 277 aa overlap. FT Similar to many bacterial hypothetical proteins e.g. FT Streptomyces coelicolor SCE87.04C, conserved hypothetical FT protein, TR:Q9RKD4 (EMBL:AL132674) (286 aa); Fasta score FT E(): 0, 50.5% identity in 277 aa overlap. Contains Pfam FT match to entry PF00590 TP_methylase, Tetrapyrrole FT (Corrin/Porphyrin) Methylases.." FT /db_xref="GOA:Q9CD60" FT /db_xref="InterPro:IPR008189" FT /db_xref="UniProtKB/TrEMBL:Q9CD60" FT /protein_id="CAC29701.1" FT /translation="MTYGRLLLGATPLGQPLDASRRLTDALCCADVVAAEDTRRARTLA FT KTLGVVITGRVISLFDQIEAVRVSALVAEIEAGATVLVISDAGMSVISDPGYRLVAACI FT AAGLPVRCLPGPSAVMTALAVSGLSSEKFCFEGFAPRKSSARRTWLASLADERRTCVFF FT ESPRRLAACLRDAVDQLGSARPVVVCRELTKVHEEVVRGSLDELATWAANGVLGEITVV FT LAGATPRADLFLLVPEVENLVAGGARVKDACGQVAAVHSSVRSRQLYDAVLRARQVSSR FT " FT misc_feature 258658..259269 FT /note="Pfam match to entry PF00590 TP_methylase, FT Tetrapyrrole (Corrin/Porphyrin) Methylases., score 86.20, FT E-value 6.7e-22" FT repeat_region complement(259473..260254) FT /note="Dispersed repeat, RLEP, copy 3" FT CDS complement(260507..260906) FT /pseudo FT /transl_table=11 FT /gene="PE_PGRS" FT /gene_synonym="ML0194" FT /product="PE_PGRS-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3653, PE_PGRS (Best blastx score 94)" FT CDS complement(261342..262320) FT /pseudo FT /transl_table=11 FT /gene="ML0195" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3651 (Best blastx score 218)" FT CDS complement(262754..262939) FT /pseudo FT /transl_table=11 FT /gene="PE" FT /gene_synonym="ML0196" FT /product="PE-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3650, PE (Best blastx score 94)" FT CDS complement(263238..264560) FT /pseudo FT /transl_table=11 FT /gene="ML0197" FT /product="ATP-dependent DNA/RNA helicase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3649 (Best blastx score 213)" FT RBS 264881..264886 FT /note="possible RBS" FT misc_feature 264898..265098 FT /note="Pfam match to entry PF00313 CSD, 'Cold-shock' FT DNA-binding domain, score 150.80, E-value 2.4e-41" FT CDS 264898..265101 FT /transl_table=11 FT /gene="cspA" FT /gene_synonym="ML0198" FT /product="putative cold shock protein" FT /note="Similar to M. tuberculosis cspA, Rv3648c, probable FT cold shock protein, SW:CSPA_MYCTU (O06360) (67 aa); Fasta FT score E(): 3.9e-27, 97.0% identity in 67 aa overlap. FT Similar to many e.g. Arthrobacter globiformis csp, cold FT shock protein, SW:CSP_ARTGO (P54584) (67 aa); Fasta score FT E(): 8.8e-19, 71.6% identity in 67 aa overlap. Previously FT sequenced as TR:O69550 (EMBL:AL023093) (67 aa); Fasta score FT E(): 1.2e-27, 100.0% identity in 67 aa overlap. Contains FT Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding FT domain. Contains PS00352 'Cold-shock' DNA-binding domain FT signature." FT /note="Similar to ML2147" FT /db_xref="GOA:O69550" FT /db_xref="HSSP:1HZC" FT /db_xref="InterPro:IPR012340" FT /db_xref="UniProtKB/TrEMBL:O69550" FT /protein_id="CAC29706.1" FT /translation="MPQGTVKWFNAEKGFGFIAPEDGSADVFVHYTEIQGSGFRTLEEN FT QKVEFEIGHSPKGPQATGVRSV" FT misc_feature 264940..264999 FT /note="PS00352 'Cold-shock' DNA-binding domain signature" FT CDS 265213..265815 FT /transl_table=11 FT /gene="ML0199" FT /note="Similar to M. tuberculosis Rv3647c, hypothetical FT protein, TR:O06361 (EMBL:AL123456) (192 aa); Fasta score FT E(): 0, 80.4% identity in 199 aa overlap. Previously FT sequenced as TR:O69549 (EMBL:AL023093) (200 aa); Fasta FT score E(): 0, 99.5% identity in 200 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O69549" FT /protein_id="CAC29707.1" FT /translation="MSQLSFFTAESLLPAIADLAGVLAASGQIVVVSASGQSPAPAARL FT SVVVDQLWRASALAEMISEAGLVPEISRTEEDTPLVRTAVDPLLCPIAAEWTRGAVKTV FT PPRWLPGPRELRAWILAAGVPEAANRYLLGLDPHAPDTHSPLASALMRVGIAPTLIGTR FT SGRPALRISGRRRLSRLLENVGEPPDWAEALALWPRV" FT CDS 266033..268876 FT /transl_table=11 FT /gene="topA" FT /gene_synonym="ML0200" FT /product="putative DNA topoisomerase I" FT /EC_number="5.99.1.2" FT /note="Similar to M. tuberculosis topA, DNA topoisomerase FT I, SW:TOP1_MYCTU (Q59567) (934 aa); Fasta score E(): 0, FT 84.3% identity in 942 aa overlap. Previously sequenced as FT SW:TOP1_MYCLE (O69548) (947 aa); Fasta score E(): 0, 100.0% FT identity in 947 aa overlap. Contains Pfam match to entry FT PF01131 Topoisom_bac, Prokaryotic DNA topoisomerase. FT Contains Pfam match to entry PF01751 Toprim, Toprim domain. FT Contains PS00396 Prokaryotic DNA topoisomerase I active FT site." FT /db_xref="GOA:O69548" FT /db_xref="HSSP:1ECL" FT /db_xref="InterPro:IPR006171" FT /db_xref="UniProtKB/Swiss-Prot:O69548" FT /protein_id="CAC29708.1" FT /translation="MKGPRGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRG FT HIRDLPRTAADVPAKFKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDEL FT YLATDGDREGEAIAWHLMQTLKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQE FT TRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAK FT LDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTL FT AAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGY FT ITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGET FT FATPDAVCNELDGDEFRIYELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGR FT TLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTE FT ASLVKALEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLV FT DYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGID FT AREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDDGELTPQRANLNGTLTPDELTLE FT VAEELFATPHEGRVLGVDPETGHEIVAKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKK FT GRRASASQGPKPRTGSLLRSMDLQTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYG FT PYLKRGKDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPPLRELGTDPTSGKPM FT LIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGPVKRPAKKARKVPA FT KKAARLAPARGISQSPR" FT misc_feature 266078..266446 FT /note="Pfam match to entry PF01751 Toprim, Toprim domain, FT score 150.70, E-value 2.6e-41" FT misc_feature 266483..267805 FT /note="Pfam match to entry PF01131 Topoisom_bac, FT Prokaryotic DNA topoisomerase, score 657.00, E-value FT 9.7e-194" FT misc_feature 267029..267073 FT /note="PS00396 Prokaryotic DNA topoisomerase I active site" FT CDS complement(268857..270449) FT /transl_table=11 FT /gene="ML0201" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3645, probable FT transmembrane protein, TR:O06362 (EMBL:AL123456) (549 aa); FT Fasta score E(): 0, 85.3% identity in 530 aa overlap and to FT several other putative membrane proteins from M. FT tuberculosis. Shares regions of similarity with adenylate FT cyclases e.g. Anabaena sp. (strain PCC 7120) cyaA, FT adenylate cyclase, TR:P94180 (EMBL:D89622) (735 aa); Fasta FT score E(): 1.5e-16, 33.3% identity in 228 aa overlap. FT Previously sequenced as TR:O69547 (EMBL:AL023093) (530 aa); FT Fasta score E(): 0, 99.8% identity in 530 aa overlap. FT Contains hydrophobic, possible membrane-spanning regions. FT Contains Pfam match to entry PF00672 DUF5, Domain found in FT bacterial signal proteins. Contains 2 Pfam matches to entry FT PF00211 guanylate_cyc, Adenylate and Guanylate cyclase FT catalytic domain." FT /db_xref="GOA:O69547" FT /db_xref="InterPro:IPR003660" FT /db_xref="UniProtKB/TrEMBL:O69547" FT /protein_id="CAC29709.1" FT /translation="MATQAAGLPGRIGAFVRWGIRTPWPLFSLSMLQSDIIGALFVLGF FT LRYGLPPQDRVELQDLPIRNLAISTLSVVVAFSTGFAVNLKLLMPVFRWQRRDNRLAEA FT DPAATELARSRALRMPFYHTIISLVTWGIGGAVFIIASWSAARHSAPIVALATALGATA FT TAIIGYLQSERVLRPVAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVLAIVLAVVA FT DKIALLHAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIADPLRQLRWALSEVQRGNYN FT AHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVARRALEHGTELGGQER FT DVAVLFVDLIGSTQLAETKPPTKVVHLLNEFFRVVVDTVGRHGGFVNKFQGDAALAIFG FT APIEHPDSAGAALSAARELHDELLPVLGSAEFGIGVSAGRAIAGHIGAQARFEYTVIGD FT PVNEAARLTELAKLEDGHVLASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLARPLN FT LAVPEQITSEVTG" FT misc_feature complement(269052..269162) FT /note="Pfam match to entry PF00211 guanylate_cyc, Adenylate FT and Guanylate cyclase catalytic domain, score 25.40, FT E-value 1.3e-05" FT misc_feature complement(269247..269450) FT /note="Pfam match to entry PF00211 guanylate_cyc, Adenylate FT and Guanylate cyclase catalytic domain, score 31.20, FT E-value 3.4e-07" FT misc_feature complement(269526..269735) FT /note="Pfam match to entry PF00672 DUF5, Domain found in FT bacterial signal proteins, score 63.60, E-value 4.3e-15" FT CDS 270605..271822 FT /transl_table=11 FT /gene="ML0202" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3644c, hypothetical FT protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score FT E(): 0, 84.4% identity in 404 aa overlap. Similar to the FT N-termini of many DNA polymerase III subunits e.g. FT Escherichia coli holB, DNA polymerase III, delta' subunit, FT SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, FT 35.1% identity in 205 aa overlap. Previously sequenced as FT TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, FT 100.0% identity in 405 aa overlap." FT /note="Similar to the N-terminus of ML2335" FT /db_xref="GOA:O69546" FT /db_xref="HSSP:1JR3" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:O69546" FT /protein_id="CAC29710.1" FT /translation="MSGVFTRLVGQDAVEAELLAAAKAARSDLVHSRPADGTMTHAWLI FT TGPPGSGRSVAAVCFAAALQCTADFQDGGPGCGRCRACTTTMAGTHADVRRVIPDGLSI FT GVDEMRAIVHEASRRPSTGYWQIVLIEDADRLTEGAANALLKVVEEPPSSTVFLLCAPS FT VAPEDIAVTLRSRCRHVALVTPSHAAIARVLIDSDGLAADTANWAALVSGGHVGLARRL FT ATDPEAQQRRERAFGLIRDAVVPSRAYAVAEELVAAAEAEALVLTAERAEAETEELRTA FT LGAGGTGKGTAGALRSVTGAIKDLERRQKSRQTRASRDALDRVLIDLATYFRDALLVSA FT NAGSVQPNHPDMADRVAVLACHATPERLLRCIEAVLECREALAVNVKPKFAVDALVATI FT GQELRY" FT tRNA 271901..271976 FT /gene="thrU" FT /note="tRNA Thr anticodon CGT, Cove score 85.20" FT CDS complement(273290..274999) FT /transl_table=11 FT /gene="ML0203" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3635, probable membrane FT protein, TR:O06372 (EMBL:AL123456) (591 aa); Fasta score FT E(): 0, 77.2% identity in 569 aa overlap. Previously FT sequenced as TR:O69545 (EMBL:AL023093) (569 aa); Fasta FT score E(): 0, 99.8% identity in 569 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:O69545" FT /protein_id="CAC29711.1" FT /translation="MLAFRGYFYWDDLILIGKTGTQGLLSASYLFDDHDGHLMPAAFLV FT AGALIRLAPLVWTGPAISLVFLQLLVSLTLLRALYVILGWRRVLLIPLTFGLFTPLAVP FT GFAWWAAALNSLPMLAALGWVCADAILLVCTGNHRYAATGVMVYCGGLLFFEKAAVIPF FT VAFAVAALLRHVRGDHAALRTVWRDGLRLWITSLTLTVIWVTLYLAVINQQRWSFDLSM FT TGQLLLRSITHGIVPGLAGGPWHWDRWAPASPWAAPPPLVMALGWLLLIGVLALSLVHK FT QRIRLVWLTAAGYTVTCQLPIYLMRSSQQTALELAQTLRYLPDLVIVLALLTAIAFHAP FT NRAFAARWLDTSPTRTGVTTGIAGLFLASSLYSTVTFLTSWRDNPTQLYLQNVRADLAA FT MHAASSAPLLDSEVDQLVLQRVAWPENLASHMFALLRDRPEFASATSHLMMLNSSGSLI FT EARVTWIRTIVAGLTPHCGYFVRPDRPTRMMLDGPLLPADWTVELNYLANRDGLMTLSL FT TQGPSVKVPVHPGLNRVYARLPGAGDAITVLANTTTLSLCIASGPVGFLAPA" FT CDS 275049..276008 FT /transl_table=11 FT /gene="rmlB2" FT /gene_synonym="ML0204" FT /product="putative sugar-nucleotide dehydratase" FT /note="Similar to M. tuberculosis rmlB2, possible FT dTDP-Glucose 4,6-dehydratase, TR:O06373 (EMBL:AL123456) FT (314 aa); Fasta score E(): 0, 86.1% identity in 309 aa FT overlap. Similar to bacterial sugar-nucleotide dehydratases FT (many putative) e.g. Streptomyces venezuelae desIV, FT TDP-glucose-4,6-dehydratase, TR:Q9ZGH3 (EMBL:AF079762) (337 FT aa); Fasta score E(): 1.4e-24, 34.3% identity in 321 aa FT overlap. Previously sequenced as TR:O69544 (EMBL:AL023093) FT (319 aa); Fasta score E(): 0, 100.0% identity in 319 aa FT overlap. Contains Pfam match to entry PF01370 Epimerase, FT NAD dependent epimerase/dehydratase family. Contains FT PS00061 Short-chain dehydrogenases/reductases family FT signature." FT /note="Similar to ML1964" FT /db_xref="GOA:O69544" FT /db_xref="HSSP:1N7H" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:O69544" FT /protein_id="CAC29712.1" FT /translation="MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAAN FT LEHLASTPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDASVNVI FT GTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAGEIYLN FT TFRHLCGLDCSHIAPANVYGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVF FT VDDVVDAFIKASGDAGGGQRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLK FT RSCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS" FT misc_feature 275070..275999 FT /note="Pfam match to entry PF01370 Epimerase, NAD dependent FT epimerase/dehydratase family, score 276.90, E-value FT 2.7e-79" FT misc_feature 275460..275546 FT /note="PS00061 Short-chain dehydrogenases/reductases family FT signature" FT repeat_region complement(276000..276785) FT /note="Dispersed repeat, RLEP, copy 4" FT CDS complement(276707..277777) FT /transl_table=11 FT /gene="ML0205" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3629c, possible FT membrane protein, TR:O06378 (EMBL:AL123456) (365 aa); Fasta FT score E(): 0, 66.2% identity in 361 aa overlap. Similar to FT other bacterial hypothetical membrane proteins e.g. FT Streptomyces coelicolor SCC8A.24C, putative integral FT membrane protein, TR:CAB92842 (EMBL:AL356892) (380 aa); FT Fasta score E(): 1e-21, 47.5% identity in 377 aa overlap. FT Previously sequenced as TR:O69543 (EMBL:AL023093) (356 aa); FT Fasta score E(): 0, 100.0% identity in 356 aa overlap. FT Contains hydrophobic, possible membrane-spanning regions." FT /db_xref="InterPro:IPR007427" FT /db_xref="UniProtKB/TrEMBL:O69543" FT /protein_id="CAC29713.1" FT /translation="MAAFRGFGISLLTTAIALLVAYIYGGLASLLPLIVLAIFEVSLSF FT DNAIINAAILKQMSRFWRKMFLTIGILIAAFGMRLIFPAVIVWATAKLDPVRTMDLALH FT PPPNHALEFPDGSPSYQKLIMSAHPQIAAFGGTFLLMLFLDFVFQDRDIKWLKWIEAPF FT TRIGRLGPLSVVAIFVLVLIATALTHSGDERAKVLIAGLLSLVTYLLVSVLNRAFRPPD FT IDTASGRRMAGRAGLVRFLYLEILDATFSFDGVTGAFAITSDPVIIALGLGLISSVFIR FT SITIYLVHQDALDRYVYLEYGAHWAIGALSVMMLLSVEPRFEILEAVTALVGVLFIGAA FT LTWSVFRNHREVKACT" FT RBS complement(277782..277788) FT /note="possible RBS" FT CDS 277944..279039 FT /pseudo FT /transl_table=11 FT /gene="ML0206" FT /product="unknown membrane protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3630 (Best blastx score 392)" FT CDS 279051..279770 FT /transl_table=11 FT /gene="ML0207" FT /product="putative glycosyltransferase" FT /note="Similar to M. tuberculosis Rv3631, possible FT glycosyltransferase, TR:O06376 (EMBL:AL123456) (241 aa); FT Fasta score E(): 0, 80.8% identity in 239 aa overlap. FT Similar to many bacterial hypothetical proteins. Previously FT sequenced as TR:O69542 (EMBL:PS50167) (239 aa); Fasta score FT E(): 0, 99.6% identity in 239 aa overlap. Contains Pfam FT match to entry PF00535 Glycos_transf_2, Glycosyl FT transferases." FT /note="Similar to ML1440" FT /db_xref="GOA:O69542" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:O69542" FT /protein_id="CAC29715.1" FT /translation="MGIETCYPGVWIVIPAFNEAAIIGEVVTDVRAVFDHVVCVDDGSA FT DGTGEIALRAGAHLVRHPVNLGQGAAIQTGVEYARRQPAAQVFATFDADGQHRVKDLAA FT LVDRLGAHDVDVVIGTRFGRLDGGRLPILKGPPFLKRVVLRTAARLSRRGRRLGLTDTN FT NGLRVFNKKVADGLDITMTGMSHANEFVMLIADNHWRVDEVPVEVLYTEYSKSKGQPLL FT NGVNIIFDGFLRGRMPK" FT misc_feature 279081..279572 FT /note="Pfam match to entry PF00535 Glycos_transf_2, FT Glycosyl transferases, score 57.10, E-value 3.8e-13" FT RBS 279771..279776 FT /note="possible RBS" FT CDS 279784..280125 FT /transl_table=11 FT /gene="ML0208" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3632, hypothetical FT protein, TR:O06375 (EMBL:AL123456) (114 aa); Fasta score FT E(): 0, 82.0% identity in 111 aa overlap. Previously FT sequenced as TR:O69541 (EMBL:AL023093) (113 aa); Fasta FT score E(): 0, 100.0% identity in 113 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:O69541" FT /protein_id="CAC29716.1" FT /translation="MNWIQVLLIGSIIVLLIYLLRSRRNVRSRAWVKVGYIAFVLGGVY FT AVLRPNDTTVVAHWFGVCRGTDLMLYALIMAFSFTTLSIYIRFKDLELRYACLARVVAL FT EGARAPEPF" FT repeat_region 279989..280838 FT /note="Dispersed repeat, RLEP, copy 5" FT CDS complement(280783..281282) FT /pseudo FT /transl_table=11 FT /gene="ML0209" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv1748 (Best blastx score 146)" FT CDS complement(281543..282031) FT /transl_table=11 FT /gene="ppa" FT /gene_synonym="ML0210" FT /product="putative inorganic pyrophosphatase" FT /EC_number="3.6.1.1" FT /note="Similar to M. tuberculosis ppa, Rv3628, probable FT inorganic pyrophosphatase, SW:IPYR_MYCTU (O06379) (162 aa); FT Fasta score E(): 0, 89.5% identity in 162 aa overlap. FT Similar to many e.g. Sulfolobus acidocaldarius ppa, FT inorganic pyrophosphatase, SW:IPYR_SULAC (P50308) (173 aa); FT Fasta score E(): 1.1e-27, 45.9% identity in 159 aa overlap. FT Previously sequenced as SW:IPYR_MYCLE (O69540) (162 aa); FT Fasta score E(): 0, 99.4% identity in 162 aa overlap. FT Contains Pfam match to entry PF00719 Pyrophosphatase, FT Inorganic pyrophosphatase. Contains PS00387 Inorganic FT pyrophosphatase signature." FT /db_xref="GOA:O69540" FT /db_xref="HSSP:2PRD" FT /db_xref="InterPro:IPR008162" FT /db_xref="UniProtKB/Swiss-Prot:O69540" FT /protein_id="CAC29718.1" FT /translation="MQFDVTIEIPKGQRNKYEVDHKTGRVRLDRYLYTPMAYPTDYGFI FT EDTLGEDGDPLDALVLLPEPLFPGVLVEARPVGMFRMVDEHGGDDKVLCVPVNDHRWDH FT IHGIIDVPTFELDAIKHFFVHYKDLEPGKFVKAADWVGRDEAEAEVQRSVERFKAGGH" FT misc_feature complement(281555..282022) FT /note="Pfam match to entry PF00719 Pyrophosphatase, FT Inorganic pyrophosphatase, score 172.10, E-value 9.3e-48" FT misc_feature complement(281858..281878) FT /note="PS00387 Inorganic pyrophosphatase signature" FT RBS complement(282040..282045) FT /note="possible RBS" FT RBS 282147..282152 FT /note="possible RBS" FT CDS 282157..283542 FT /transl_table=11 FT /gene="ML0211" FT /product="putative carboxypeptidase" FT /note="Similar to M. tuberculosis Rv3627c, possible FT penicillin-binding protein, TR:O06380 (EMBL:AL123456) (461 FT aa); Fasta score E(): 0, 76.0% identity in 462 aa overlap. FT Shows weak similarity to penicillin-binding proteins e.g. FT Neisseria gonorrhoeae pbp3, penicillin binding protein 3, FT TR:O85665 (EMBL:AF071224) (469 aa); Fasta score E(): FT 4.5e-08, 33.1% identity in 163 aa overlap. Similar to FT putative carboxypeptidases from Streptomyces coelicolor FT e.g. SCE9.15C, possible penicillin-binding protein, FT TR:Q9X8I8 (EMBL:AL049841) (459 aa); Fasta score E(): FT 3.8e-32, 36.3% identity in 435 aa overlap. Previously FT sequenced as TR:O69539 (EMBL:AL023093) (461 aa); Fasta FT score E(): 0, 99.8% identity in 461 aa overlap. Contains a FT possible N-terminal signal sequence. Contains Pfam match to FT entry PF02113 Peptidase_S13, D-Ala-D-Ala carboxypeptidase 3 FT (S13) family." FT /db_xref="GOA:O69539" FT /db_xref="InterPro:IPR000667" FT /db_xref="UniProtKB/TrEMBL:O69539" FT /protein_id="CAC29719.1" FT /translation="MNPIRWQKSYVVVGLAMLAFIIAAVKAATVFTTGGHSTNGARSAV FT PPPRASTVKPALVPVTETAVVPSVGGLAAALASALADPSLGSFGGRITDAMTAKELWQQ FT QDDMPLVPASANKLLTAAAALLTLDRQTRISTRVVAAGPNAQGPVVLVGAGDPTLSAAS FT PDQSTWYRGAPRISDLVEQVRRSGVTPTAVQVDTSLFTGPTMAQGWDPADVDNGYTAPI FT ESAMIDAGRIQPTTVKSRRSRTPALDAGRELAKALGVAPDAVTIVKASSGARQLAVVQS FT APLVQRLSEMMDNSDNVLAECIGREVAAAINRPLSFAGAVDAVTNRLGTAHIDTTGAAL FT VDSSGLSVNNRLTAKTLGGAVQAAAGPDQPVLRALLDLLPIAGGSGTLSDRFLSSATHQ FT GPAGWLRAKTGSLTAINSLVGVVTDRSGRVLTFAFISNDAGPTGRAAMDELATRLWMCG FT CAT" FT misc_feature 282439..283467 FT /note="Pfam match to entry PF02113 Peptidase_S13, FT D-Ala-D-Ala carboxypeptidase 3 (S13) family, score 519.60, FT E-value 2.3e-152" FT CDS 283539..284579 FT /pseudo FT /transl_table=11 FT /gene="ML0212" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3626c (Best blastx score 1003)" FT CDS 284580..285551 FT /transl_table=11 FT /gene="mesJ" FT /gene_synonym="ML0213" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis mesJ, Rv3625c, conserved FT hypothetical protein, SW:Y0C5_MYCTU (O06382) (323 aa); FT Fasta score E(): 0, 78.0% identity in 327 aa overlap. FT Similar to many e.g. Escherichia coli mesJ, putative cell FT cycle protein, SW:MESJ_ECOLI (P52097) (432 aa); Fasta score FT E(): 3.9e-12, 33.0% identity in 279 aa overlap. Previously FT sequenced as SW:Y0C5_MYCLE (O69538) (323 aa); Fasta score FT E(): 0, 100.0% identity in 323 aa overlap." FT /db_xref="GOA:O69538" FT /db_xref="HSSP:1NI5" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:O69538" FT /protein_id="CAC29721.1" FT /translation="MDRQGAVGQLRRTVEEFAGTYCDIDDQWCVALSGGSDSLALTAVA FT AQLRSTTAFIVDHGLQSDSAAVAETARKQAISLGCVDAQVLCVQIDPPFGPKGGLEAAA FT RAARYAVLGANRNGPVLLAHTLDDQAETVLLGLGRGSGARSIAGMRPHDPPWCRPLLGV FT RRSVPRAACHELGLNAWQDPHNTDCRYTRTRLRLEVLPLLEDVLGGGVVEALARTATAL FT REDTELIDTFAAQALPNICAGSGLHARALAALPDAVRRRVIRGWLLNGGATGLTDKQIR FT GVDTLVTAWRGQGGVAVGSTLRGQRLIASRYDGVLTLHCAPV" FT CDS 285584..286225 FT /transl_table=11 FT /gene="hpt" FT /gene_synonym="ML0214" FT /product="putative hypoxanthine phosphoribosyltransferase" FT /EC_number="2.4.2.8" FT /note="Similar to M. tuberculosis hpt, Rv3624c, probable FT hypoxanthine-guanine phosphoribosyltransferase, FT SW:HPRT_MYCTU (O06383) (216 aa); Fasta score E(): 0, 83.1% FT identity in 207 aa overlap. Similar to many e.g. Salmonella FT typhimurium hprt, hypoxanthine phosphoribosyltransferase, FT TR:O33799 (EMBL:AF008931) (178 aa); Fasta score E(): FT 9.6e-32, 50.9% identity in 169 aa overlap. Previously FT sequenced as TR:O69537 (EMBL:AL023093) (213 aa); Fasta FT score E(): 0, 99.5% identity in 213 aa overlap. Contains FT Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl FT transferase domain. Contains PS00103 Purine/pyrimidine FT phosphoribosyl transferases signature." FT /db_xref="GOA:O69537" FT /db_xref="HSSP:1J7J" FT /db_xref="InterPro:IPR000836" FT /db_xref="UniProtKB/Swiss-Prot:O69537" FT /protein_id="CAC29722.1" FT /translation="MVFRRAAWHALLVAQSFSAINPGPTAELYLGDIKSVMLTQEQIQA FT RIAELGAQIGHDYRDRSPASDQDLLLVTVLKGAVIFVTDLARAIPLPTQFEFMAVSSYG FT SSMSSSGVVRILKDLDRDIHDRNVLIVEDVVDSGLTLSWLLRNLATRRPQSLQVCTLLR FT KPDALRANVDITYVGFDIPNDFVVGYGLDYDERYRDLPYIGMLDPRVYQQ" FT misc_feature 285665..286147 FT /note="Pfam match to entry PF00156 Pribosyltran, FT Phosphoribosyl transferase domain, score 84.60, E-value FT 2e-21" FT misc_feature 285965..286003 FT /note="PS00103 Purine/pyrimidine phosphoribosyl FT transferases signature" FT CDS complement(286276..286674) FT /pseudo FT /transl_table=11 FT /gene="ML0215" FT /product="putative lipoprotein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lpqG (Best blastx score 222)" FT CDS complement(286829..287302) FT /pseudo FT /transl_table=11 FT /gene="ML0216" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv0393 (Best blastx score 102)" FT repeat_region 287703..287723 FT /note="21 bp direct repeat, TGTTGTCTTAGAGCATTGATT" FT repeat_region 287724..287744 FT /note="21 bp direct repeat, TGTTGTCTTAGAGCATTGATT" FT CDS 288678..288923 FT /transl_table=11 FT /gene="ML0217" FT /product="hypothetical protein" FT /note="Unknown function. Possibly the remains of a FT disrupted gene." FT /db_xref="UniProtKB/TrEMBL:Q9CD59" FT /protein_id="CAC29725.1" FT /translation="MGVGRPCAEEPQTGFVVLHADGLSGGAGSSAIHAQFFQLGFRPIK FT ALLSAAGGEALAYAELSPVGWQYINTALRRIDELSA" FT CDS complement(289829..290215) FT /transl_table=11 FT /gene="ML0218" FT /product="hypothetical protein" FT /note="Improbable CDS suggested by GC frameplot. Possibly FT the remains of a disrupted gene. Previously sequenced as FT TR:O69534 (EMBL:AL023093) (128 aa); Fasta score E(): 0, FT 99.2% identity in 128 aa overlap." FT /db_xref="UniProtKB/TrEMBL:O69534" FT /protein_id="CAC29726.1" FT /translation="MEPLVRPSMCRPTGLTTLRSKDPRQGNWPVTVSSEVAANGDHVFG FT AGFSTDCLIFLDTIGKSGRRCYYRPWSAPAGRTSLIGAVTIPLAALTTKPIASSYAVGT FT ASNSDKTIKNHMWFLLVCVGYPRY" FT CDS complement(290378..290991) FT /pseudo FT /transl_table=11 FT /gene="ML0219" FT /product="Putative alcohol dehydrogenase, zinc-type FT (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue Rv3726 (Best blastx score 114)" FT CDS complement(291435..292461) FT /pseudo FT /transl_table=11 FT /gene="ML0220" FT /product="similar bacterial luciferase alpha chains FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv3618 (Best blastx score 208)" FT CDS complement(292471..293353) FT /pseudo FT /transl_table=11 FT /gene="ML0221" FT /product="putative hydrolase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT ephA (Best blastx score 177)" FT CDS 293693..296065 FT /transl_table=11 FT /gene="ftsH" FT /gene_synonym="ML0222" FT /product="putative integral membrane peptidase" FT /note="Similar to M. tuberculosis ftsH, Rv3610c, possible FT cell division protein, SW:FTSH_MYCTU (P96942) (760 aa); FT Fasta score E(): 0, 87.2% identity in 790 aa overlap. FT Similar to many e.g. Escherichia coli ftsH, cell division FT protein, SW:FTSH_ECOLI (P28691) (644 aa); Fasta score E(): FT 0, 49.3% identity in 611 aa overlap. Previously sequenced FT as TR:O69532 (EMBL:AL023093) (787 aa); Fasta score E(): 0, FT 100.0% identity in 787 aa overlap. Contains hydrophobic, FT possible membrane-spanning regions. Contains Pfam match to FT entry PF01434 Peptidase_M41, Peptidase family M41. Contains FT Pfam match to entry PF00004 AAA, ATPases associated with FT various cellular activities (AAA). Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). Contains PS00674 FT AAA-protein family signature." FT /db_xref="GOA:Q9CD58" FT /db_xref="HSSP:1IXZ" FT /db_xref="InterPro:IPR000642" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD58" FT /protein_id="CAC29730.1" FT /translation="MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAM FT SQINGHNVKSAQIDDREQQLRLTLKKGNNDTDGSDKVITKYPTGYAVDLFNALSAKNTK FT VTTAVNEGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKT FT TFADVAGVDEAVEELYEIKDFLQNPCRYQTLGAKIPKGVLLYGPPGTGKTLLARAVAGE FT AGVPFFTISGSDFVEMFVGVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGG FT HDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAG FT RRAVLRVHSKGKPIADDADLDGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPAL FT EEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGG FT HAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTTGAVSDIEKATKIARSMVT FT EFGMSSKLGAVRYGSEHGDPFLGRTMGTQADYSHEVARDIDDEVRKLIEAAHTEAWEIL FT TEYRDVLDTLAGELLEKETLHRPELEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPG FT ELAIERGEPWPQPVPEPAFKAAIARASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQR FT QHGPTQPDYGAPPGWHAPGWPPQQPPDYWYPPEQQPSQSPYWPQPAPSYPGQAPPPYPS FT YPPCPSYPPPGQSAPDAGKPPAQLDEGVSPSNPPAHG" FT misc_feature 294293..294856 FT /note="Pfam match to entry PF00004 AAA, ATPases associated FT with various cellular activities (AAA), score 339.00, FT E-value 5.2e-98" FT misc_feature 294308..294331 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 294605..294661 FT /note="PS00674 AAA-protein family signature" FT misc_feature 294872..295504 FT /note="Pfam match to entry PF01434 Peptidase_M41, Peptidase FT family M41, score 413.20, E-value 2.4e-120" FT RBS 296069..296075 FT /note="possible RBS" FT CDS 296082..296699 FT /transl_table=11 FT /gene="folE" FT /gene_synonym="ML0223" FT /product="putative GTP cyclohydrolase I" FT /EC_number="3.5.4.16" FT /note="Similar to M. tuberculosis folE, Rv3609c, GTP FT cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta FT score E(): 0, 82.0% identity in 205 aa overlap. Similar to FT many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, FT SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% FT identity in 190 aa overlap. Previously sequenced as FT SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% FT identity in 205 aa overlap. Contains Pfam match to entry FT PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains FT PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 FT GTP cyclohydrolase I signature 2." FT /db_xref="GOA:O69531" FT /db_xref="HSSP:1IS8" FT /db_xref="InterPro:IPR018234" FT /db_xref="UniProtKB/Swiss-Prot:O69531" FT /protein_id="CAC29731.1" FT /translation="MALLDLGLESTAVPRIRVFDQQRAEAAIRELLYAIGEDPDREGLA FT DTPARVARACRELFSGLYTDPQTVLNTMFDEEHNELVIVKEIPMYSTCEHHLVSFHGVA FT HIGYLPGADGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALVSKLDPRGVIIVVEAE FT HLCMAMRGVRKPGAITTTSAVRGQFKTDAASRAEALGLILRK" FT misc_feature 296145..296693 FT /note="Pfam match to entry PF01227 GTP_cyclohydroI, GTP FT cyclohydrolase I, score 343.60, E-value 2.2e-99" FT misc_feature 296319..296369 FT /note="PS00859 GTP cyclohydrolase I signature 1" FT misc_feature 296469..296501 FT /note="PS00860 GTP cyclohydrolase I signature 2" FT CDS 296696..297550 FT /transl_table=11 FT /gene="folP" FT /gene_synonym="ML0224" FT /product="dihydropteroate synthase" FT /EC_number="2.5.1.15" FT /note="Similar to M. tuberculosis folP, Rv3608c, FT dihydropteroate synthase, SW:DHP1_MYCTU (O06274) (280 aa); FT Fasta score E(): 0, 76.8% identity in 284 aa overlap. FT Previously sequenced as TR:O69530 (EMBL:AL023093) (284 aa); FT Fasta score E(): 0, 99.6% identity in 284 aa overlap. FT Mutations in this gene result in diaminodiphenylsulfone FT resistance. Contains Pfam match to entry PF00809 DHPS, FT Dihydropteroate synthase. Contains PS00793 Dihydropteroate FT synthase signature 2." FT /note="Similar to ML1063" FT /db_xref="GOA:P0C0X1" FT /db_xref="HSSP:1AD1" FT /db_xref="InterPro:IPR006390" FT /db_xref="UniProtKB/Swiss-Prot:P0C0X1" FT /protein_id="CAC29732.1" FT /translation="MSLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVAEGAAI FT VDVGGESTRPGAIRTDPRVELSRIVPVVKELAAQGITVSIDTTRADVARAALQSGARIV FT NDVSGGRADPAMAPLVAEAGVAWVLMHWRLMSAERPYEAPNYRDVVAEVRADLLAGVDQ FT AVAAGVDPGSLVIDPGLGFAKTGQHNWALLNALPELVATGVPILLGASRKRFLGRLLAG FT ADGAVRPPDGRETATAVISALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKVR FT CDG" FT misc_feature 296720..297502 FT /note="Pfam match to entry PF00809 DHPS, Dihydropteroate FT synthase, score 428.10, E-value 7.9e-125" FT misc_feature 296819..296860 FT /note="PS00793 Dihydropteroate synthase signature 2" FT CDS 297543..297941 FT /transl_table=11 FT /gene="folB" FT /gene_synonym="ML0225" FT /product="putative dihydroneopterin aldolase" FT /EC_number="4.1.2.25" FT /note="Similar to M. tuberculosis folX, Rv3607c, probable FT dihydroneopterin aldolase, SW:FOLB_MYCTU (O06275) (133 aa); FT Fasta score E(): 0, 74.8% identity in 131 aa overlap. FT Similar to many e.g. Staphylococcus aureus folB, FT dihydroneopterin aldolase, SW:FOLB_STAAU (P56740) (121 aa); FT Fasta score E(): 1.9e-09, 33.9% identity in 121 aa overlap. FT Previously sequenced as SW:FOLB_MYCLE (O69529) (132 aa); FT Fasta score E(): 0, 100.0% identity in 132 aa overlap. FT Contains Pfam match to entry PF02152 FolB, Dihydroneopterin FT aldolase." FT /db_xref="GOA:O69529" FT /db_xref="HSSP:1DHN" FT /db_xref="InterPro:IPR006156" FT /db_xref="UniProtKB/Swiss-Prot:O69529" FT /protein_id="CAC29733.1" FT /translation="MADRMELRGLIVRGRHGVYEVERANGQDFIVDVILWIDLADAAAN FT DNLADTYDYVVLAERTAAIIAGPPRNLIETVGSEIADFVMDDERVHAVEVVVHKPQAPI FT PQQFSDVAVVVRRSRRGGRGSMIPASGV" FT misc_feature 297555..297893 FT /note="Pfam match to entry PF02152 FolB, Dihydroneopterin FT aldolase, score 130.10, E-value 1.8e-36" FT CDS 297941..298516 FT /transl_table=11 FT /gene="folK" FT /gene_synonym="ML0226" FT /product="putative FT 2-amino-4-hydroxy-6-hydroxymethyldihydropterine FT pyrophosphokinase" FT /EC_number="2.7.6.3" FT /note="Similar to M. tuberculosis folK, Rv3607c, probable FT 2-amino-4-hydroxy-6-hydroxymethyldihydropterine FT pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta FT score E(): 0, 63.2% identity in 190 aa overlap. Similar to FT others e.g. to the C-terminal half of Streptococcus FT pneumoniae sulD, bifunctional folate synthesis protein FT (includes: dihydroneopterin aldolase and FT 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine FT pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta FT score E(): 1.8e-07, 37.8% identity in 135 aa overlap. FT Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); FT Fasta score E(): 0, 100.0% identity in 191 aa overlap. FT Contains Pfam match to entry PF01288 HPPK, FT 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). FT Contains PS00794 FT 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase FT signature." FT /db_xref="GOA:O69528" FT /db_xref="HSSP:1F9Y" FT /db_xref="InterPro:IPR000550" FT /db_xref="UniProtKB/Swiss-Prot:O69528" FT /protein_id="CAC29734.1" FT /translation="MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAV FT EQRSFLNAVVIADGPAYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQTSGA FT TTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDSDAELTVAGRAQRVDRLLAEMEPT FT EREGVRLTNLTLKLKRSSPARPVSPKSD" FT misc_feature 297947..298357 FT /note="Pfam match to entry PF01288 HPPK, FT 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), FT score 246.10, E-value 1.5e-70" FT misc_feature 298193..298228 FT /note="PS00794 FT 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase FT signature" FT CDS 298516..298992 FT /transl_table=11 FT /gene="ML0227" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3605c, hypothetical FT protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score FT E(): 0, 85.4% identity in 158 aa overlap. Previously FT sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta FT score E(): 0, 100.0% identity in 158 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:O69527" FT /protein_id="CAC29735.1" FT /translation="MGPTRKRDLTAAMIGAAVVGYLLVLVLYRWFPPITVWTGLSLLAV FT AIPEALWARYVRTKISDGEIGDGPGWLHPLAVAHSLMVAKASAWVGALVLGWWVGVLVY FT FLPRWPWLRVADKDTSGTVVAALSALALLVAALWLQHCCKSPQDPTEHGEGAEN" FT CDS 299138..300436 FT /transl_table=11 FT /gene="ML0228" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv3604c, putative FT membrane protein, TR:O06278 (EMBL:AL123456) (462 aa); Fasta FT score E(): 0, 59.7% identity in 432 aa overlap. Previously FT sequenced as TR:O69526 (EMBL:AL023093) (432 aa); Fasta FT score E(): 0, 100.0% identity in 432 aa overlap. Contains FT hydrophobic, possible membrane-spanning regions." FT /db_xref="UniProtKB/TrEMBL:O69526" FT /protein_id="CAC29736.1" FT /translation="MTVLSRGGRVRRGGRRPGWVLLTVSLILAMGASSALVFTNRVELL FT KLAVILALWAAVAGAFVSVFYRRQSDADQSRVRNLKLVYDLQLDREISARREYELTVES FT QLRRELASELRSQAADEVLALRAELAALRTNLEILFDTDLQHRPALAGAEAPQAKAAPP FT TCAYSNWVRDGQSKPVDWVPSNRVTSVRQDRVTNSADDTSIIDVPEEPLLPPRGQAPQQ FT GGVLPHFEDPPSQSDSRFEPRHRPPRSAPLQELLQPHMKDWQPDAADEQWLPPGTQDSA FT WTDVESASASVAAPSGRRRRSRHSSLDEAAASSPGEAETAQQHSGSGRRARSRHSAEYR FT AYSIEGITAKGSTPISQPTPPAGPAFAEQPPRLVPASPSDPVPRHRSADLLTDGVKGRD FT LAAGGQSVADLMARLGAESTDGGRRRRREGHYA" FT RBS 300524..300527 FT /note="possible RBS" FT CDS 300537..301466 FT /transl_table=11 FT /gene="ML0229" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3603c, hypothetical FT protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score FT E(): 0, 67.8% identity in 311 aa overlap. Similar to the FT N-terminal half of Streptomyces coelicolor SCE126.02C, FT hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); FT Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. FT Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); FT Fasta score E(): 0, 100.0% identity in 309 aa overlap." FT /db_xref="InterPro:IPR019665" FT /db_xref="UniProtKB/TrEMBL:O69525" FT /protein_id="CAC29737.1" FT /translation="MVQFDGLRSARLNIAILSTGRVGVALERADQVVVACSAVSHASRQ FT WVQFRLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTSVPRPGTIVAHTSWAN FT GVGILAQLGKDGCIPLAIHPAMMFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVL FT EMGGEPFCVVEYARILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRG FT EVVDDQLDVIVERIVGSLARAACENTLQRGQAGLTKLVARGDLDALAGHLVALMRIGPE FT LAQAYRVNALRKTQRAHAPYDVVEALAP" FT CDS 301463..302404 FT /transl_table=11 FT /gene="panC" FT /gene_synonym="ML0230" FT /product="putative pantoate-[beta]-alanine ligase" FT /EC_number="6.3.2.1" FT /note="Similar to M. tuberculosis panC, putative FT pantoate-[beta]-alanine ligase, SW:PANC_MYCTU (O06280) (309 FT aa); Fasta score E(): 0, 82.2% identity in 297 aa overlap. FT Similar to many e.g. Escherichia coli FT pantoate--beta-alanine ligase, SW:PANC_ECOL (P31663) (283 FT aa); Fasta score E(): 0, 46.1% identity in 269 aa overlap. FT Previously sequenced as SW:PANC_MYCLE (O69524) (191 aa); FT Fasta score E(): 0, 100.0% identity in 191 aa overlap." FT /db_xref="GOA:O69524" FT /db_xref="HSSP:1MOP" FT /db_xref="InterPro:IPR014729" FT /db_xref="UniProtKB/Swiss-Prot:O69524" FT /protein_id="CAC29738.1" FT /translation="MTNSRQPAFNPGELNVYSTPRDVTNVSSALRHTGRRVMLVPTMGA FT LHNGHLALVRAAKRVPGSVVVVSIFVNPLQFGAAEDLDTYPCTFDDDLALLRAEDVEIV FT FTPTAAAMYPHGLRTTVRPGALAFELEGGPRPNHFDGVLTVVLKLLQIVRPDRVFFGEK FT DYQQLVLIRQMVADLNVDVVVVGVPTVREVDGLAMSSRNCYLDPVQRDLAAALSAALTA FT GAHAATGGAQAALDAARAVLDATPGLVVDYVELRDAGLGPMRDNTFGRLLVAARLGATR FT LLDNISIEIGNFSGIASPDECRVEHAQTPWMK" FT CDS 302404..302832 FT /transl_table=11 FT /gene="panD" FT /gene_synonym="ML0231" FT /product="putative aspartate-1-decarboxylase" FT /EC_number="4.1.1.11" FT /note="Similar to M. tuberculosis panD, putative FT aspartate-1-decarboxylase, SW:PAND_MYCTU (Z95557) (139 aa); FT Fasta score E(): 0, 82.9% identity in 140 aa overlap. FT Similar to Corynebacterium glutamicum panD, FT L-aspartate-alpha-decarboxylase precursor, TR:Q9X4N0 FT (EMBL:AF116184) (136 aa); Fasta score E(): 9.3e-29, 68.8% FT identity in 128 aa overlap." FT /db_xref="GOA:Q9CD57" FT /db_xref="HSSP:1AW8" FT /db_xref="InterPro:IPR003190" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD57" FT /protein_id="CAC29739.1" FT /translation="MLRTMLKSKIHRATVTQAYLHYVGSVTIDADLMGAADLLEGEQVT FT IVDINNGARLVTYAIAGERGTGVIGINGAAAHLVHPGDLVILISYGTMEDAEAHAYQPR FT IVFVDADNKPIDLGHDPGSVPLDISVAAELFDPRIGAR" FT CDS 302835..303659 FT /transl_table=11 FT /gene="ML0232" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv3600c, conserved FT hypothetical protein, TR:O06282 (EMBL:AL123456) (272 aa); FT Fasta score E(): 0, 90.5% identity in 274 aa overlap. FT Similar to otehr bacterial hypothetical proteins e.g. FT Streptomyces coelicolor SCE94.31C, hypothetical protein, FT TR:Q9X8N6 (EMBL:AL049628) (265 aa); Fasta score E(): 0, FT 52.0% identity in 269 aa overlap." FT /db_xref="GOA:Q9CD56" FT /db_xref="InterPro:IPR004619" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD56" FT /protein_id="CAC29740.1" FT /translation="MLLAIDVRNTHTVVGLLSGSKEHAKVVQQWRIRTESEVTADELAL FT IIDGLIGDDSERLAGAAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDN FT PKEVGADRIVNCLAAFHKFGQAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAA FT AARSAALRRVELARPRSVVGKNTVECMQAGVVFGFAGLVDGLVGRMRQDVEEFSGDLGN FT RVAVVATGHTAPLLLPELHTVDHYDRHLTLHGLRLVFERNREAQRGRLKTAR" FT RBS 303717..303720 FT /note="possible RBS" FT CDS 303740..305263 FT /transl_table=11 FT /gene="lysS" FT /gene_synonym="ML0233" FT /product="putative lysyl-tRNA synthase" FT /EC_number="6.1.1.6" FT /note="Similar to M. tuberculosis lysS, Rv3598c, putative FT lysyl-tRNA synthase, SW:SYK_MYCTU (O06284) (505 aa); Fasta FT score E(): 0, 85.4% identity in 501 aa overlap. Similar to FT Escherichia coli lysU, lysyl-tRNA synthase, SW:SYK2_ECOLI FT (P14825) (504 aa); Fasta score E(): 0, 38.8% identity in FT 497 aa overlap. Contains Pfam match to entry PF00152 FT tRNA-synt_2, tRNA synthetases class II (D, K and N). FT Contains PS00179 Aminoacyl-transfer RNA synthetases FT class-II signature 1." FT /note="Similar to the C-terminal half of ML1393" FT /db_xref="GOA:P46861" FT /db_xref="HSSP:1BBW" FT /db_xref="InterPro:IPR004365" FT /db_xref="UniProtKB/Swiss-Prot:P46861" FT /protein_id="CAC29741.1" FT /translation="MNADPLETDAALPEQFRIRRDKRARLLAEGRDPYPVAIERTHTLA FT EVRAAYPDLATDSATDDIVGIAGRVIFARNSGKLCFATLQDGDGTNLQVMISLNKVGSE FT TLDAWKVDVDLGDIVYVHGNVISSRSGELSVLADSWQMVSKSLRPLPVAHKEMSEESRV FT RQRYVDLIVCPQVRIVAHQRIAVIRAIRTALERRGFLEVETPMLQTLAGGAAARPFVTH FT SNALDIDLYLRIAPELFLKRCIVGGFDKVFELNRVFRNEGADSTHSPEFSMLETYQTYG FT TYDDSAVVTREIIQEVADEAIGTRQLQMPDDSVYDIDGEWETIQMYPSLSAVLGEEITP FT QTSVDRLRAIADRLGRGIGPEILDKPSYGHGRLVEQLWEYTVGNTLSAPTFVKDFPVET FT TPLTRQHRSIPGVTEKWDLYLRGVELATGYSELNDPVVQRERFGQQVRAAAAEEDEAMA FT LDEEFLAALEYAMPPCTGTGMGIDRLLMSLTGLSIRETVLFPIVRPHSN" FT misc_feature 304211..305251 FT /note="Pfam match to entry PF00152 tRNA-synt_2, tRNA FT synthetases class II (D, K and N), score 375.40, E-value FT 5.6e-109" FT misc_feature 304511..304564 FT /note="PS00179 Aminoacyl-transfer RNA synthetases class-II FT signature 1" FT RBS 305356..305359 FT /note="possible RBS" FT CDS 305368..305706 FT /transl_table=11 FT /gene="lsr2" FT /gene_synonym="ML0234" FT /product="lsr2 protein (15 kDa antigen)" FT /note="Similar to M. tuberculosis lsr2, putative lsr FT protein, SW:LSR2_MYCTU (O06285) (112 aa); Fasta score E(): FT 0, 92.9% identity in 112 aa overlap. Homologues also occur FT in Streptomyces coelicolor e.g. Streptomyces coelicolor FT SCE94.26C, putative lsr2-like protein, TR:Q9X8N1 FT (EMBL:AL049628) (111 aa); Fasta score E(): 7.3e-18, 56.3% FT identity in 112 aa overlap. Previously sequenced as SW:." FT /db_xref="GOA:P24094" FT /db_xref="UniProtKB/Swiss-Prot:P24094" FT /protein_id="CAC29742.1" FT /translation="MAKKVTVTLVDDFDGAGAADETVEFGLDGVTYEIDLTNKNAAKLR FT GDLRQWVSAGRRVGGRRRGRSNSGRGRGAIDREQSAAIREWARRNGHNVSTRGRIPADV FT IDAFHAAT" FT RBS 305988..305994 FT /note="possible RBS" FT CDS 306003..308549 FT /transl_table=11 FT /gene="clpC" FT /gene_synonym="ML0235" FT /product="putative ATP-dependent Clp protease" FT /note="Similar to M. tuberculosis clpC, ATP-dependent Clp FT protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): FT 0, 97.2% identity in 845 aa overlap. Similar to many e.g. FT Bacillus subtilis clpC, negative regulator of genetic FT competence (clpC-family) and Treponema hyodysenteriae tlyB, FT hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score FT E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam FT match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains FT Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains FT 2 x PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="Similar to ML2490" FT /db_xref="GOA:P24428" FT /db_xref="HSSP:1JBK" FT /db_xref="InterPro:IPR001943" FT /db_xref="UniProtKB/Swiss-Prot:P24428" FT /protein_id="CAC29743.1" FT /translation="MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVA FT AKSLDSLGISLEAVRSQVEDIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIG FT TEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESG FT SPSTSLVLDQFGRNLTAAAMESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGK FT TAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGD FT IILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALER FT RFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKA FT IDLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASLRDREKQLV FT AQRAEREKQWRSGDLDVIAEVDDEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKR FT IIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDA FT LIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIY FT NSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFTQGSGENDYERMK FT QKVNDELKKHFRPEFLNRIDDIIVFHQLSRDEIIRMVDLMISRVANQLKVKDMTLELTN FT KAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVVTVDVDNWDGEGP FT GEDVKFTFTGIRKPSTEPDLAKAGVHSAGGPEPVEQ" FT misc_feature 306648..306671 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT misc_feature 307275..307382 FT /note="Pfam match to entry PF02151 UVR, UvrB/uvrC motif, FT score 39.60, E-value 7e-08" FT misc_feature 307434..308408 FT /note="Pfam match to entry PF00495 clpA_B, Chaperonin FT clpA/B, score 647.10, E-value 9.5e-191" FT misc_feature 307659..307682 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT repeat_region 308814..308841 FT /note="14 copies of dinucleotide repeat, AT " FT CDS complement(309643..310899) FT /transl_table=11 FT /gene="pabB" FT /gene_synonym="ML0236" FT /product="putative para-aminobenzoate synthase component" FT /note="EC_number=4.1.3.-" FT /note="Similar to M. tuberculosis pabB, Rv1005c, putative FT para-aminobenzoate synthase component I, TR:O05591 FT (EMBL:Z94752) (458 aa); Fasta score E(): 0, 79.1% identity FT in 412 aa overlap. Similar to many e.g. Escherichia coli FT para-aminobenzoate synthase component I, SW:PABB_ECOLI FT (P05041) (453 aa); Fasta score E(): 5.5e-31, 35.2% identity FT in 378 aa overlap. When compared to the predicted M. FT tuberculosis translation, this CDS is missing the FT N-terminal 30 aa, thus it may be a pseudogene. Contains FT Pfam match to entry PF00425 chorismate_bind, chorismate FT binding enzyme." FT /note="Similar to the C-terminal halves of ML0808 and FT ML1269" FT /db_xref="GOA:Q7AQL1" FT /db_xref="HSSP:1K0G" FT /db_xref="InterPro:IPR019999" FT /db_xref="UniProtKB/TrEMBL:Q7AQL1" FT /protein_id="CAC29744.1" FT /translation="MRIERLGNLGDAPRVLRSLGDATTGLDLPPPAALTGEWFDALAII FT APSLSVQPVDVNDAFAVQLDARTPDSAVAVGGGWVGYLSYPDPAADKQPNRIPEAAGGW FT TDCVLRRDRGAQWWYESLSGAPMPGWLAAALATTPAPARNCQVDWERTDWGAHRDGVLA FT CLEAIRAGEIYQACVCTQFTGTVTGAPLDFFIAVVARTAPARAAYIAGPWGAVASLSPE FT LFLRRRGAGVTSSPIKGTLPLAAWPSALQASAKEVAENIMIVDLVRNDLGRVAITGTVT FT VPELLVVRHAPGVWHLVSTVTAQVPVELPMAALLDATFPPASITGTPKLRARKLISQWE FT HRRRGIYCGTVGLASPIAGCELNVAIRTVEFDTAGNAVLGVGGGITADSDPDAELQECL FT HKAAPILRLASVATVASVG" FT misc_feature complement(309676..310242) FT /note="Pfam match to entry PF00425 chorismate_bind, FT chorismate binding enzyme, score 192.30, E-value 6.7e-55" FT CDS 310900..311580 FT /pseudo FT /transl_table=11 FT /gene="ML0237" FT /product="hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1006 (Best blastx score 389)" FT CDS complement(312208..313821) FT /transl_table=11 FT /gene="metS" FT /gene_synonym="ML0238" FT /product="putative methionyl-tRNA synthase" FT /EC_number="6.1.1.10" FT /note="Similar to M. tuberculosis metS, Rv1007c, FT methionyl-tRNA synthetase, SW:SYM_MYCTU (O05593) (519 aa); FT Fasta score E(): 0, 85.7% identity in 516 aa overlap. FT Similar to many e.g. Bacillus stearothermophilus metG FT (metS), methionyl-tRNA synthetase, SW:SYM_BACST (P23920) FT (649 aa); Fasta score E(): 0, 40.9% identity in 550 aa FT overlap. Contains Pfam match to entry PF00133 tRNA-synt_1, FT tRNA synthetases class I (I, L, M and V). Contains PS00178 FT Aminoacyl-transfer RNA synthetases class-I signature." FT /db_xref="GOA:Q9CD55" FT /db_xref="HSSP:1A8H" FT /db_xref="InterPro:IPR014758" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD55" FT /protein_id="CAC29746.1" FT /translation="MRPYYITTAIAYPNAAPHIGHAYEYIATDAIARFKRLDGLDVRFL FT TGTDEHGLKVAQAAEAAGVPTAQLARRNSGVFQRMQEALHISFDRFIRTTDADHYKAAK FT EIWRRMDAAGDIYLGTYSGWYSVRDERFFVDSETKLLDNGIRVAVETGTLVTWTEKEQT FT YFFRLSAYVDKLLAHYDANPDFIGPEVRRNEVISFVSGGLEDFSISRTSFDWGVQVPEH FT PDHVMYVWIDALTNYLTGAGFPDTDSELFGRYWPANLHMIGKDIIRFHAVYWPAFLMSA FT GIELPRRIFAHGFLHNHGEKMSKSVGNIVDPMALVQTFGVDQVRYFLLREIPFGQDGNY FT SEEAIITRMNTDLANEFGNLAQRSLSMVAKNLGGVVPEPSEFTSADTALLTTADGLLER FT VRGNFDGQAMNLALEAIWLMLGEANKYFSSQQPWILRKSESEADQARFRTVLYTTCEVV FT RIAALLVQPVMPESAGKMLDLLGQEEDQRAFTAVSVRLAPGTVLPPPTGVFPRYQPSEI FT EGADPVKSSSKRREHNKRRE" FT misc_feature complement(312619..313821) FT /note="Pfam match to entry PF00133 tRNA-synt_1, tRNA FT synthetases class I (I, L, M and V), score -186.40, E-value FT 1.5e-07" FT misc_feature complement(313756..313785) FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I FT signature" FT misc_feature 313910..313936 FT /note="PS01137 Uncharacterized protein family UPF0006 FT signature 1" FT CDS 313910..314698 FT /transl_table=11 FT /gene="ML0239" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis ycfH, Rv1008, conserved FT hypothetical protein, TR:O08343 (EMBL:AL123456) (264 aa); FT Fasta score E(): 0, 82.3% identity in 260 aa overlap. FT Similar to many e.g. Bacillus subtilis yabD, conserved FT hypothetical protein, SW:YABD_BACSU (P37545) (255 aa); FT Fasta score E(): 0, 41.0% identity in 261 aa overlap. FT Contains Pfam match to entry PF01026 UPF0006, Metalloenzyme FT of unknown function. Contains PS01137 Uncharacterized FT protein family UPF0006 signature 1. Contains PS01091 FT Uncharacterized protein family UPF0006 signature 3." FT /db_xref="GOA:Q9CD54" FT /db_xref="HSSP:1J6O" FT /db_xref="InterPro:IPR018228" FT /db_xref="UniProtKB/TrEMBL:Q9CD54" FT /protein_id="CAC29747.1" FT /translation="MVDAHTHLDACGARDADDVNAIVERAAAVGVVAVVTVADDLESAR FT WVIAAAGWDRRVYAAVALHPTRANSLTSAARAKIEQLAAHPRMVAVGETGMDLYWPGRL FT DSCAPPDVQREAFAWHIDLAKRCGKPLMIHNRQADAEVLDVLRAEGAPEQVIFHCFSSN FT AAMARRCVDAGWMLSLSGTVSFRNARPLREAVPLIPAQQLLVETDAPFLTPHPHRGLAN FT EPYCLPYTVRAVAELVERSPEELAQITTSNALRVYKLGSV" FT misc_feature 313925..314683 FT /note="Pfam match to entry PF01026 UPF0006, Metalloenzyme FT of unknown function, score 348.40, E-value 7.8e-101" FT misc_feature 314489..314539 FT /note="PS01091 Uncharacterized protein family UPF0006 FT signature 3" FT RBS 314928..314932 FT /note="possible RBS" FT CDS 314948..316075 FT /transl_table=11 FT /gene="ML0240" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1009, conserved FT hypothetical protein, TR:O05594 (EMBL:AL123456) (362 aa); FT Fasta score E(): 0, 82.3% identity in 361 aa overlap. The FT C-terminus is similar to a region conserved in many FT bacterial hypothetical proteins e.g. Streptomyces FT coelicolor SCE87.01C, hypothetical protein, TR:Q9RKD7 FT (EMBL:AL132674) (330 aa); Fasta score E(): 3.2e-14, 33.8% FT identity in 225 aa overlap." FT /note="C-terminus is similar to region of ML2030 and FT ML2151" FT /db_xref="GOA:Q9CD53" FT /db_xref="InterPro:IPR010618" FT /db_xref="UniProtKB/TrEMBL:Q9CD53" FT /protein_id="CAC29748.1" FT /translation="MNVLTRLHETSSPIFRLVVGVLLLVIAFAGGYAVAAYKTVTLTVD FT GTPMQVMTMKSRVIDIIQENGFAVGECDDLYPAADVSVHATDNIVLRRSRPLQISLDGK FT DIQQVWTTASTVDEALVQLALTDTAPIVASRGSRVPLTGMALPVVSAKTVQINDGGAVR FT MVHLPASNVGGLLAAVGIPLLASDQVSPSATSPIVEGMQIQVTRNRIERVIERIPLPPS FT SRSIEDPEMNISRVVVEDPGTPGTQDVTFAVATVNGVETGRLPVANVVVEPARESVIRV FT GTKPGTEVPPVSDGSIWDAIAGCEAGGNWAINTGNGYYGGVQFDQGTWVANGGLRYAPR FT ADLATREEQIAVAEVTRARQGWDAWPVCSGRVGAH" FT RBS 316026..316030 FT /note="possible RBS" FT CDS 316048..316968 FT /transl_table=11 FT /gene="ksgA" FT /gene_synonym="ML0241" FT /product="putative dimethyladenosine transferase" FT /note="EC_number=2.1.1.-" FT /note="Similar to M. tuberculosis ksgA, dimethyladenosine FT transferase, TR:O05595 (EMBL:AL123456) (317 aa); Fasta FT score E(): 0, 85.0% identity in 294 aa overlap. Similar to FT many e.g. Escherichia coli ksgA, dimethyladenosine FT transferase, SW:KSGA_ECOLI (M68521) (273 aa); Fasta score FT E(): 8.3e-23, 33.7% identity in 261 aa overlap. Contains FT Pfam match to entry PF00398 RrnaAD, Ribosomal RNA adenine FT dimethylases. Contains PS01131 Ribosomal RNA adenine FT dimethylases signature." FT /db_xref="GOA:Q9CD52" FT /db_xref="InterPro:IPR001737" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD52" FT /protein_id="CAC29749.1" FT /translation="MQRKSGCTLTIRLLERTEIRWLVKELECRPRKSLGQNFVHDANTV FT RRVVSTSRVNRSDFVLEVGPGFGSLTLALLDCGAAVSAIEIDPVLAGRLPQTVAEHSNN FT EIHRLTVCNRDVLSFRRGDLATEPTALVANLPYNVAVPALLHLLAEFPSIRTVTVMVQA FT EVAERLAAEPGGKDYGVPSVKLSFFGRVRRCGMVSPTVFWPIPRVYSGLVRVDRYATSP FT WPTDDAFRRQVFELVDIAFTQRRKTSRNAFVKWAGSSNESANRLLAASIDPARRGETLS FT IDDFVRLLRRSDGRDDAAVRSASAS" FT misc_feature 316153..316917 FT /note="Pfam match to entry PF00398 RrnaAD, Ribosomal RNA FT adenine dimethylases, score 151.60, E-value 2e-46" FT misc_feature 316225..316308 FT /note="PS01131 Ribosomal RNA adenine dimethylases FT signature" FT CDS 317042..317977 FT /transl_table=11 FT /gene="ML0242" FT /product="putative isopentenyl monophosphate kinase" FT /note="EC_number=2.7.1.-" FT /note="Similar to M. tuberculosis ipk, Rv1011, putative FT isopentenyl monophosphate kinase, SW:IPK_MYCTU (O05596) FT (306 aa); Fasta score E(): 0, 87.5% identity in 303 aa FT overlap. Similar to many e.g. Escherichia coli isopentenyl FT monophosphate kinase, SW:IPK_ECOLI (P24209) (283 aa); Fasta FT score E(): 1.3e-13, 35.6% identity in 202 aa overlap." FT /db_xref="GOA:Q9CD51" FT /db_xref="InterPro:IPR014721" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD51" FT /protein_id="CAC29750.1" FT /translation="MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVT FT VRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPVAGGMA FT GGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVL FT SRATFHWVLAFADSSLLTPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLL FT GNELQAAAVSLDPALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGA FT GVCRTVRVATGPVPGARVVHAPMSRGLNDM" FT RBS 318210..318215 FT /note="possible RBS" FT CDS 318220..319854 FT /transl_table=11 FT /gene="ML0243" FT /product="putative acyl-CoA synthetase" FT /note="Similar to several putative acyl-CoA synthases from FT M.tuberculosis e.g. pks16, Rv1013, possible polyketide FT synthase, TR:O05598 (EMBL:AL123456) (544 aa); Fasta score FT E(): 0, 82.2% identity in 544 aa overlap. Similar to FT domains of polyketide synthases e.g. Bacillus subtilis FT mycA, mycosubtilin synthetase, TR:Q9R9J1 (EMBL:AF184956) FT (3971 aa); Fasta score E(): 0, 33.7% identity in 404 aa FT overlap. Contains Pfam match to entry PF00501 AMP-binding, FT AMP-binding enzyme. Contains PS00455 Putative AMP-binding FT domain signature." FT /note="Similar to ML0887, ML0100, ML0132, ML0138, ML1051, FT ML1234, ML1994, ML2358 and ML2546" FT /db_xref="GOA:Q9CD50" FT /db_xref="InterPro:IPR000873" FT /db_xref="UniProtKB/TrEMBL:Q9CD50" FT /protein_id="CAC29751.1" FT /translation="MSKFTEKMFRNARESSKGIVTGEPHNPVRHTWGQVHERASRIAGG FT LAGVGVGHGDAVGVLVGVPVEIAPTAQGLWMRGASLTMLHQPTPRTDLAVWEEDTTTVI FT DMIEAKAVIISDPFMAVAPILEARGVKVVTVEQLLAADPVDPIETDEDDLALMQLTSGS FT TGSPKAVQITHRNVYSNVEAMFIGVRYNVEKDVMISWLPCFHDMGMIGFLTVPMYFGAE FT LVKVTPIDFLRDTLLWAKLIDKYKGTVICGPNFAYSLFTKRLRKQAKPGQFDLSTLRIA FT MSGAEPVDPADVEDLIDAGRPFGFRPEAILPAYGMAETTLAVSFSPVGEGLLVDEVDAD FT LLAALRRAVPATKGNIRRLVSLGPLLDGLEVRIVDEDGNVLPSRGVGVIELRGESLTPG FT YITMGGFISAQDEHGWYDTGDLGYQMENGHIVVCGRVKDVIIMAGRNVYPTDIERAAGR FT VDGVRPGCAVAVRLDAGHSRETFAVAVESNAFEDTAEVRRIEHQVAHEVLKEVDVRPRN FT VVVLGPGTIPKTPSGKLRRASSVTLVT" FT misc_feature 318310..319623 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score -49.80, E-value 1.2e-12" FT misc_feature 318688..318723 FT /note="PS00455 Putative AMP-binding domain signature" FT CDS complement(319965..320564) FT /transl_table=11 FT /gene="pth" FT /gene_synonym="ML0244" FT /product="putative peptidyl-tRNA hydrolase" FT /EC_number="3.1.1.29" FT /note="Similar to M. tuberculosis pth, Rv1014c, FT peptidyl-tRNA hydrolase, SW:PTH_MYCTU (P96386) (191 aa); FT Fasta score E(): 0, 77.7% identity in 188 aa overlap. FT Similar to many e.g. Escherichia coli pth, peptidyl-tRNA FT hydrolase, SW:PTH_ECOLI (P23932) (194 aa); Fasta score E(): FT 3.7e-22, 37.2% identity in 188 aa overlap. Contains Pfam FT match to entry PF01195 Pept_tRNA_hydro, Peptidyl-tRNA FT hydrolase. Contains PS01196 Peptidyl-tRNA hydrolase FT signature 2." FT /db_xref="GOA:Q9CD49" FT /db_xref="HSSP:2PTH" FT /db_xref="InterPro:IPR018171" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD49" FT /protein_id="CAC29752.1" FT /translation="MAEPTLASGWYPRLVVGLGNPGKNYGRTRHNVGFMVANLLAVRLG FT SKFEVHKRSGADVVNGRLAGCSMLVAKPRNYMNESGQQVGLLAKLYSVTPADIIIVHDD FT LDLDFGRIRLKLGGGEGGHNGLRSVAAALGTKDFQRVRIGIGRPTGRKDPASFVLENFT FT TAERMQVPTICKRAADATELLVGLGLEPAQNHVHAW" FT misc_feature complement(319974..320534) FT /note="Pfam match to entry PF01195 Pept_tRNA_hydro, FT Peptidyl-tRNA hydrolase, score 297.90, E-value 1.2e-85" FT misc_feature complement(320178..320210) FT /note="PS01196 Peptidyl-tRNA hydrolase signature 2" FT CDS complement(320577..321224) FT /transl_table=11 FT /gene="rplY" FT /gene_synonym="ML0245" FT /product="putative 50S ribosomal protein L25" FT /note="Similar to M. tuberculosis rplY, 50S ribosomal FT protein L25, SW:RL25_MYCTU (P96385) (215 aa); Fasta score FT E(): 0, 73.9% identity in 218 aa overlap. Similar to many FT e.g. Escherichia coli rplY, 50S ribosomal protein L25, FT SW:RL25_ECOLI (P02426) (94 aa); Fasta score E(): 0.00054, FT 33.7% identity in 89 aa overlap. Contains Pfam match to FT entry PF01386 Ribosomal_L25p, Ribosomal L25p family." FT /db_xref="GOA:Q9CD48" FT /db_xref="HSSP:1DFU" FT /db_xref="InterPro:IPR020057" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD48" FT /protein_id="CAC29753.1" FT /translation="MAKSTVNKLSVSVRTNTGKGASRRARRDGKVPAVLYGHGEEPQHL FT ELPAHAFSAVLRHVGTNAVLTLEVAGKEQLALTKAIDVHPIRHTIMHADLLVVRSGEKI FT VVEVPVEVEGDAGPDILVTQETTSIEIEAEALSIPEQLTMSIEGAEPGTQFTARQIPLP FT VGVTLVSDPEMLVVNVVNAPTDAQTKAKYAGEAHEAPEVGTAENKTAATESE" FT misc_feature complement(320940..321200) FT /note="Pfam match to entry PF01386 Ribosomal_L25p, FT Ribosomal L25p family, score 149.60, E-value 5.4e-41" FT RBS complement(321232..321237) FT /note="possible RBS" FT CDS complement(322399..323055) FT /transl_table=11 FT /gene="lpqT" FT /gene_synonym="ML0246" FT /product="putative lipoprotein" FT /note="Similar to M. tuberculosis lpqT, putative FT lipoprotein, SW:LPQT_MYCTU (P96384) (226 aa); Fasta score FT E(): 0, 67.1% identity in 213 aa overlap. Also similar to FT M. tuberculosis MTC28, Rv0040c, proline rich 28 kDa antigen FT precursor, SW:PR28_MYCTU (P71697) (311 aa); Fasta score FT E(): 1.3e-10, 33.3% identity in 159 aa overlap. Contains a FT probable N-terminal signal sequence. Contains PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site." FT /note="Similar to ML0031, except at N-terminus" FT /db_xref="GOA:Q9CD47" FT /db_xref="InterPro:IPR019674" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD47" FT /protein_id="CAC29754.1" FT /translation="MQAIRLGLHTAAAVVTLSISAVSCGTKTPDYQLILSKSSTTTTTT FT PDKPIPLPQYLESIGVTGQQVAPSSLPGLTVSIPTPPGWSPYSNPNITPETLIIAKSGK FT YPTARLVAFKLRGDFDPTQVIKHGNDDAQLFENFRQLDVSTANYNGFPSAMIQGSYDLE FT GRRLHAWNRIVIPTGPPPSKQQYLVQLTITSLANEAVAQSNDIEAIIRGFVVAPK" FT misc_feature complement(322984..323016) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(323092..323406) FT /transl_table=11 FT /gene="arsC" FT /gene_synonym="ML0247" FT /product="putative arsenate reductase" FT /note="Similar to many e.g. Escherichia coli arsC, arsenate FT reductase, SW:ARC1_ECOLI (P08692) (141 aa); Fasta score FT E(): 1.7e-07, 38.8% identity in 103 aa overlap. Similar to FT proteins which expand the substrate specificity of arsAB FT pump." FT /db_xref="HSSP:1J9B" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/TrEMBL:Q9CD46" FT /protein_id="CAC29755.1" FT /translation="MYSTSCKMLNLVRKKDFNHITAEYLSMPPSRSELVKIIHIDDVDV FT LTAVRKHEPFDAELNLATATDEQLLDSMAEHNTRFKRLFVVTPKGARQAKPIDAVHEIR FT " FT CDS complement(323462..324445) FT /transl_table=11 FT /gene="prsA" FT /gene_synonym="ML0248" FT /product="putative ribose-phosphate pyrophosphokinase" FT /note="Similar to M. tuberculosis prsA, ribose-phosphate FT pyrophosphokinase, TR:P96383 (EMBL:AL123456) (326 aa); FT Fasta score E(): 0, 92.0% identity in 326 aa overlap. FT Similar to many e.g. Bacillus subtilis prs, FT ribose-phosphate pyrophosphokinase, SW:KPRS_BACSU (P14193) FT (317 aa); Fasta score E(): 0, 45.8% identity in 323 aa FT overlap. Contains Pfam match to entry PF00156 Pribosyltran, FT Phosphoribosyl transferase domain. Contains PS00103 FT Purine/pyrimidine phosphoribosyl transferases signature." FT /db_xref="GOA:Q9CD45" FT /db_xref="HSSP:1DKR" FT /db_xref="InterPro:IPR005946" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD45" FT /protein_id="CAC29756.1" FT /translation="MLSHDWTDNRKNLMLFSGRAHPELAEQVAKELDMHVTTQDAREFA FT NGEIFVRFHESVRGCDAFVLQSCPAPVNTWLMEQLIMIDALKRGSAKRITAVIPFYPYA FT RQDKKHRGREPISARLVADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGY FT IKNNYPDTNMVVVSPDSGRVRIAEKWGDALGGVPLAFIHKTRDLRVPNQVVSNRVVGEV FT EGRTCVLIDDMIDTGGTVAGAVQLLRNDGASDVIIAATHGVLSPPAAERLAQYGTREVI FT VTNTLPIGEEKRFPQLTVLSIAPLLASTIRAIFENGSVTGLFDGEA" FT misc_feature complement(323594..324016) FT /note="Pfam match to entry PF00156 Pribosyltran, FT Phosphoribosyl transferase domain, score 95.00, E-value FT 1.5e-24" FT misc_feature complement(323729..323767) FT /note="PS00103 Purine/pyrimidine phosphoribosyl FT transferases signature" FT RBS complement(324451..324454) FT /note="possible RBS" FT CDS complement(324556..326034) FT /transl_table=11 FT /gene="glmU" FT /gene_synonym="ML0249" FT /product="putative UDP-N-acetylglucosamine FT pyrophosphorylase" FT /EC_number="2.7.7.23" FT /note="Similar to M. tuberculosis glmU, putative FT UDP-N-acetylglucosamine pyrophosphorylase, TR:P96382 FT (EMBL:AL123456) (495 aa); Fasta score E(): 0, 82.1% FT identity in 492 aa overlap. Similar to many e.g. Neisseria FT gonorrhoeae glmU, UDP-N-acetylglucosamine FT pyrophosphorylase, SW:GLMU_NEIGO (Q50986) (456 aa); Fasta FT score E(): 0, 37.4% identity in 462 aa overlap. Contains FT Pfam match to entry PF00483 NTP_transferase, Nucleotidyl FT transferase. Contains 5 Pfam matches to entry PF00132 FT hexapep, Bacterial transferase hexapeptide (four repeats)." FT /db_xref="GOA:Q9CD44" FT /db_xref="HSSP:1HM9" FT /db_xref="InterPro:IPR005882" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD44" FT /protein_id="CAC29757.1" FT /translation="MTFRGDTAVLVLAAGPGSRMRSDTPKVLHTIAGRSMLSHSLHAIT FT KLAPQHLVVVLGHEHQRIAPLVAELADTLERTIDVALQDRPRGTGHAVFCGLSALPDDY FT GGIVVVTSGDTPLLDANTLAELIATHNATSAAVTVLTTTFSDPLGYGRILRTQDNEVMA FT IIEHADASPSQREIREVNAGVYAFDITALRSALIRLNSNNTQQELYLTDVISILRREGQ FT KVNAQHIDDNALVAGVNNRVQLAELSAELNRRIVATHQVAGVTIIDPATTWIDIDVTIG FT NDTVIHPGTQLLGRTQIGECCVIGPDTTLTDVLVSQRATVVRTHGTSSTIGAGAMVGPF FT TYLRPGTVLGTKGKLGAFVETKNSTIGTGAKVPHLTYVGDADIGEHSNIGASSVFVNYD FT GTAKQRTTIGSHVRTGSDTKFVAPVTVGDGAYTGAGTVVRNDVPPGALAVSVSPQRNIE FT NWVQRKRPGSAAAQAAEKASTRTGKQSQQKSEPD" FT misc_feature complement(324715..324768) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 9.10, E-value FT 44" FT misc_feature complement(324895..324948) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 8.60, E-value FT 53" FT misc_feature complement(325000..325053) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 11.30, FT E-value 23" FT misc_feature complement(325099..325152) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 13.10, FT E-value 6.6" FT misc_feature complement(325153..325206) FT /note="Pfam match to entry PF00132 hexapep, Bacterial FT transferase hexapeptide (four repeats), score 17.00, FT E-value 0.44" FT misc_feature complement(325303..326013) FT /note="Pfam match to entry PF00483 NTP_transferase, FT Nucleotidyl transferase, score -0.80, E-value 1.3e-07" FT RBS complement(326040..326044) FT /note="possible RBS" FT tRNA complement(326132..326203) FT /gene="glnT" FT /note="tRNA Gln anticodon TTG, Cove score 52.56" FT CDS 326387..326995 FT /pseudo FT /transl_table=11 FT /gene="ML0250" FT /product="transcriptional regulator (TetR/AcrR family) FT (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1019 (Best blastx score 404)" FT CDS complement(327120..327945) FT /pseudo FT /transl_table=11 FT /gene="ML0251" FT /product="putative diaminopimelate decarboxylase FT (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue lysA (Best blastx score 114)" FT CDS 328067..331741 FT /transl_table=11 FT /gene="mfd" FT /gene_synonym="ML0252" FT /product="putative transcription-repair coupling factor" FT /note="Similar to M. tuberculosis mfd, transcription-repair FT coupling factor, SW:MFD_MYCTU (P96380) (1234 aa); Fasta FT score E(): 0, 84.3% identity in 1229 aa overlap. Similar to FT many e.g. Escherichia coli mfd, transcription-repair FT coupling factor, SW:MFD_ECOLI (P30958) (1148 aa); Fasta FT score E(): 0, 38.1% identity in 1111 aa overlap. Contains FT Pfam match to entry PF00271 helicase_C, Helicases conserved FT C-terminal domain. Contains Pfam match to entry PF00270 FT DEAD, DEAD/DEAH box helicase." FT /db_xref="GOA:Q9CD43" FT /db_xref="HSSP:1D9X" FT /db_xref="InterPro:IPR004576" FT /db_xref="UniProtKB/TrEMBL:Q9CD43" FT /protein_id="CAC29760.1" FT /translation="MTAPGPACLDTPIAGLVELALTAPTFGQLMERAGTRPAELILAGP FT ACARLFVASALARLGPLLVVTATGREASNLTAELRGVFGAAVAMFPSWETLPHERLSPG FT VDTVGARLMVLRRLAHPDDARLGPPLQVVVTAVRSLLQPMTAQLGLVEPVTLSVGDEIG FT FERVIARLVELAYTRVDMVGRRGEFAVRGGILDIFGPTAEHPVRVEFWGDEITEMRMFS FT VVDQRSIPEIGVDTLVAIACRELLLSDDVRARAVELAAQAAARRPTEEPAISGSVTDVL FT AKLAEGIPVDGMEALLPVLCPDDYALLTDQFAADTPVLLCDPEKVRIQAADLIKTDRAF FT LEASWSVAAIGADNAAPVDVEQLYGSGFVELGDVQAAAIRSGHPWWTLSQLSDESALEL FT DIRAAPSTRGHQHAIDGIFAMLRAHVATGGYAAIVTPGTGTAHRVVERLAESDIPGAML FT EPAAAPGLGLRPGLVGVLKGPLLDGVVIPGANLVIITEADLTGSRATPVEGKRLAAKRR FT SAADPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASNKKSKQADKLYVP FT MDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARCAVREIAGELVSLYAKRQASPGHAF FT GPDTPWQAEMEDAFGFTETVDQLTAITEVKGDMEKSVPMDRVICGDVGYGKAEIAVRAA FT FKAVQDGKQVAVLVPTTLLADQHLRTFTERMAGFPVTVKGLSRFTDAAESRAVIDGLAE FT GSVDIVIGTHRLLQTGVCWKDLGLVVVDEEQWFGVEHKEHIKSLRTHVDVLTMSATPIP FT RTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQVAAALRRELLRDGQAFYVHNRV FT SSIYQAAARVCGLVPEARVVVAHGQMPEDLLETTMRGFWNREYDILVCTTIVETGLDIP FT NANTLVVERADTFGLSQLHQLRGRVGRSHERGYAYFLYPPQAPLTEIAYDRLVTIAQNN FT ELGAGMAVALKDLEIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYRAVADGKTAI FT TPEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDTEVAAVVDELIDRYGAL FT PEPAQRLVAVAQLRLLCRGSGIIEVTAPSASTMRLSPIRLIDSAQVRLKRMYPGAQYRA FT TAATVQVPIPRAGSSGGTLGVPCIRDVELVQAVADLITALQGLPRKVIGITGPEPTSK" FT misc_feature 329996..330583 FT /note="Pfam match to entry PF00270 DEAD, DEAD/DEAH box FT helicase, score 73.60, E-value 2.2e-22" FT misc_feature 330692..330943 FT /note="Pfam match to entry PF00271 helicase_C, Helicases FT conserved C-terminal domain, score 63.10, E-value 6.1e-15" FT CDS 331780..332529 FT /pseudo FT /transl_table=11 FT /gene="ML0253" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1021 (Best blastx score 252)" FT CDS 332923..333664 FT /pseudo FT /transl_table=11 FT /gene="lpqU" FT /gene_synonym="ML0254" FT /product="lipoprotein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT lpqU (Best blastx score 224)" FT RBS 333730..333734 FT /note="possible RBS" FT CDS 333751..335094 FT /transl_table=11 FT /gene="eno" FT /gene_synonym="ML0255" FT /product="putative enolase" FT /EC_number="4.2.1.11" FT /note="Similar to M. tuberculosis eno, putative enolase, FT SW:ENO_MYCTU (P96377) (429 aa); Fasta score E(): 0, 88.8% FT identity in 429 aa overlap. Similar to many e.g. Bacillus FT subtilis eno, enolase (2-phosphoglycerate dehydratase), FT SW:ENO_BACSU (P37869) (430 aa); Fasta score E(): 0, 58.8% FT identity in 425 aa overlap. Contains Pfam match to entry FT PF00113 enolase, Enol-ase. Contains PS00164 Enolase FT signature." FT /db_xref="GOA:Q9CD42" FT /db_xref="HSSP:1OEP" FT /db_xref="InterPro:IPR000941" FT /db_xref="UniProtKB/Swiss-Prot:Q9CD42" FT /protein_id="CAC29763.1" FT /translation="MSPPTGRPRLSHDYKENLVPVIEQVGAREILDSRGNPTVEVEVVL FT IDGTFARAAVPSGASTGEYEAVELRDGDGRYGGKGVKRAVDAVLDEIGPVVIGLNANDQ FT RLIDQELLDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYIGGSNAHILPVPM FT MNILNGGAHADTAVDVQEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKKGLSTGLGDE FT GGFAPEVAGTTAALDLVTLAIEAAGFKPGADVALALDAAATEFYTDGIGYHFEGMTHTA FT DQMTEFYADLLGSYPLVSIEDPLSEDDWDGWAALTASIGEQVQIVGDDIFATNPERLEE FT GIGRGVANALLVKVNQIGTLTETLEAVALAHHSGYRTMISHRSGETEDTMIADLVVALG FT SGQIKTGAPARSERVAKYNQLLRIEEELGDAARYAGDLAFLRYVVETR" FT misc_feature 333808..335076 FT /note="Pfam match to entry PF00113 enolase, Enol-ase, score FT 773.50, E-value 8.3e-229" FT misc_feature 334798..334839 FT /note="PS00164 Enolase signature" FT RBS 335108..335111 FT /note="possible RBS" FT CDS 335129..335812 FT /transl_table=11 FT /gene="ML0256" FT /product="putative membrane protein" FT /note="Similar to M. tuberculosis Rv1024, hypothetical FT protein, TR:P96376 (EMBL:AL123456) (228 aa); Fasta score FT E(): 0, 70.5% identity in 220 aa overlap. Contains FT hydrophobic, possible membrane-spanning region." FT /db_xref="GOA:Q9CD41" FT /db_xref="InterPro:IPR007060" FT /db_xref="UniProtKB/TrEMBL:Q9CD41" FT /protein_id="CAC29764.1" FT /translation="MSEAKRLDPKRRSPASRPGKAGDSVRGRRSTKPVAKLSVKPSRTT FT PASSHSGRNSTRMLTQHVVEPIRQSIIESRERRSDQQLGFTARRAAVLAAVVCVLTLTI FT AGPVRTYFAQHAEIEQLAATEATLRRQIADLEQQKGKLADSAYIAARARERLGFVMPGD FT VPFQVQLPSTAAVSSQPGGRAAKPANNDPWYTSLWHNIADAPHLPPGAGTPPFSLTPLS FT TTSGG" FT CDS 335805..336308 FT /transl_table=11 FT /gene="ML0257" FT /product="conserved hypothetical protein" FT /note="Similar to M. tuberculosis Rv1025, hypothetical FT protein, TR:P96375 (EMBL:AL123456) (155 aa); Fasta score FT E(): 0, 85.1% identity in 154 aa overlap. Also similar to FT hypothetical proteins from Thermotoga maritima e.g. TM1078, FT hypothetical protein, TR:Q9X0G7 (EMBL:AE001768) (170 aa); FT Fasta score E(): 2.4e-09, 32.6% identity in 172 aa FT overlap." FT /db_xref="InterPro:IPR007511" FT /db_xref="UniProtKB/TrEMBL:Q9CD40" FT /protein_id="CAC29765.1" FT /translation="MVDRADLEAVARHLGREPRGVLEIAYRCPSGEPGVVKTAPKLDDG FT TPFPTLYYLTHPVLIAAASRLESTGLMREMTERLGQDPELAAGYRRAHESYLTERDAIE FT SLGTTFSAGGMPDRVKCLHVLIAHSLAKGPGLNSLGDEVLALLAADPKTAATLVAGQWK FT ECDR" FT RBS 336291..336295 FT /note="possible RBS" FT CDS 336305..337258 FT /transl_table=11 FT /gene="ML0258" FT /product="hypothetical protein" FT /note="Similar to M. tuberculosis Rv1026, hypothetical FT protein, TR:P96374 (EMBL:AL123456) (319 aa); Fasta score FT E(): 0, 77.6% identity in 321 aa overlap. Similar to many FT bacterial hypothetical proteins and shows weak similarity FT to N-terminal half of Escherichia coli ppx, FT exopolyphosphatase, SW:PPX_ECOLI (P29014) (512 aa); Fasta FT score E(): 6.8e-07, 25.3% identity in 297 aa overlap." FT /note="Shows weak similarity to ML2434" FT /db_xref="InterPro:IPR003695" FT /db_xref="UniProtKB/TrEMBL:O69585" FT /protein_id="CAC29766.1" FT /translation="MSRVAAIDCGTNSIRLLIADVAGRKLRDVHREMRIVRLGQGVDAT FT GEFALDAIARTRAALVDYTALLSAHRVERVRMVATSAARDVVNRDVLFAMTADVLGTVI FT PGSVAEVITGAEEADLSFDGAVGELDSAGAPFVVIDLGGGSTEIVLGGGSAECGVVASY FT SADIGCVRLTERCLHSDPPTPEEVAAARKVVRERLEVALQMVSVEQARTWVGLAGTMTT FT LSALAQNMMTYDAAAIHLSRVRGSDLMEVCDRLIGMTRVQRVALPSMHASRADVIGGGA FT VLVQELVRELRTWAGIDELIVSERDILDGIVLSIAG" FT CDS 337531..339287 FT /pseudo FT /transl_table=11 FT /gene="ML0259" FT /product="conserved large membrane protein (pseudogene)" FT /note="Possible pseudogene similar to M. tuberculosis FT paralogue mmpL4 (Best blastx score 308)" FT CDS complement(339324..340503) FT /pseudo FT /transl_table=11 FT /gene="ML0260" FT /product="sensor histidine kinase (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1032c (Best blastx score 284)" FT CDS complement(340549..341173) FT /pseudo FT /transl_table=11 FT /gene="ML0261" FT /product="two-component response regulator (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1033c (Best blastx score 192)" FT CDS complement(341956..342250) FT /pseudo FT /transl_table=11 FT /gene="ML0262" FT /product="conserved hypothetical protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1038c (Best blastx score 310)" FT CDS complement(343372..343984) FT /pseudo FT /transl_table=11 FT /gene="PE" FT /gene_synonym="ML0263" FT /product="PE-family protein (pseudogene)" FT /note="Possible pseudogene of M. tuberculosis orthologue FT Rv1040c, PE (Best blastx score 122)" XX SQ Sequence 344050 BP; 68744 A; 93769 C; 104705 G; 76832 T; 0 other; atgtttgtac cgcacgccaa aaagcccgaa atttacgaga accagagaga tacgtcgttg 60 gccgatgacc ttagtctagg tttcaccacg gtttggaacg cagtcgtctc cgaactcaac 120 ggcgaatcca acacagacga cgaagccacc aacgacagca ccctagtcac tccgctaact 180 cctcagcaaa gagcatggct aaatctggtt caaccactca ccatcatcga gggatttgct 240 cttttatcgg tgcccagcag ctttgtccaa aatgaaattg aacgtcatct acgaacgcca 300 atcaccgatg cactcagccg tcgactcgga caacagatac agctcggagt ccgtatcgca 360 ccgccctcta ccgaccatat tgacgacaat tcctcgtcag ccgacgtcct tctaaccgac 420 gattgcggca cagatacaga cgaaaattac ggggagcctc ttacaggcga gtaccagggt 480 ttgccaacct acttcaccga acgtccgcac cataccgaat caaccgtcac gggaggtacc 540 agccttaatc gccgttacac cttcgaaacg ttcgttattg gcgcgtcgaa tcggttcgcg 600 catgctgccg cgctagcgat agccgaagca ccggcccgag cctacaaccc ccttttcatt 660 tggggcgagt caggtcttgg caaaacccac ctattgcacg ccgccgggaa ctacgcacaa 720 cgactgtttc ccggcatgcg ggtcaaatat gtctccacag aagaattcac caacgacttc 780 atcaactcgc tccgtgacga ccgcaaagta gcgttcaaac gcagctaccg cgacgtcgat 840 gtgctactgg tcgatgacat ccaattcatc gaaggaaaag aaggtataca agaagagttc 900 ttccatacct ttaatacctt acataacgcc aacaagcaaa tcgtcatctc ttctgaccgc 960 ccaccgaaac aactcgccac cctcgaagac cgactaagga cccggttcga gtgggggctt 1020 attaccgacg tacaaccccc tgaactagaa acccgcatcg ccatcttgcg taagaaagcc 1080 cagatggaac gcctagcggt gcctggcgat gtcctcgaac tcatcgccag cagtatcgaa 1140 cgtaacatcc gtgaactcga gggagctctc atcagagtca ccgcgtttgc ttcgctcaac 1200 aagactgcaa tcgacaaagc attagcggaa atcgtactgc gtgacctgat cgcagacgcc 1260 agcacgatgc aaatcagtgc ggcaaccata atgacagcca ccgccgaata cttcgatacc 1320 accatcgaag aactccgtgg gccaggcaaa acccgagcac tggcccagtc acgccagatc 1380 gcgatgtatt tgtgtcgtga actcaccgac ctctcgctac ccaagatcgg ccaagcattc 1440 ggccgtgacc acaccacggt tatgtacgca caacgaaaaa tcttgtccga gatggctgaa 1500 cgtcgcgaag tgttcgacca cgtcaaggaa ctcaccactc gcatccggca acggtctaag 1560 cgctgacttt cgatgcgcaa cacatacttt ctccagaaaa acttcttgca cttaagtcac 1620 atcagtcaca tttccaaagt gtgtatattt ctgtggacaa actaagtata ctgacatgca 1680 acaatccttg atttcatgca cacccatagt cgatccacaa cggcgaatcg cagattcttt 1740 attatcaaca ctgacatcca cacctcaaca gctcatctag ctcaacaaaa tccggttatc 1800 cacaagatcc acacccttta atactgatac taagatttct tcgtgttctt atttaaaaaa 1860 tgatgctggg gatacagcat gccacgatgt gacggcaacc tcagccgtca ccgttgacgc 1920 tactttcaag gtggcactcg aagatctacg tttgctcttc gactactgtt agggacgtcg 1980 tggtgcacta tgtgtcaccg acgttcgtta cagtgggctc acgctagcgg gggcggaggc 2040 tagccgttgg atttcaacga tttttaggtg aaggggcgcc atggacctgg ccaaaaccaa 2100 tgttggttgc agcgatttaa aattttgttt agcacgtgag tcgttcgcca gcgcggtgtc 2160 atgggtagcg aagtatctcc ccactagacc aacggtaccg gtgctatccg gcgtgctgct 2220 gaccggttca gatagcggcc taacgatctc cggattcgat tacgaagttt ccgcagaggt 2280 gcaggttgct gccgagatag cttcttctgg aagcgttttg gtatctggga ggttgttgtc 2340 agatattact cgggcgcttc cgaacaaacc tgttcacttt tatgtggacg gtaatcgggt 2400 tgcattgact tgcggaagtg cgaggttctc gttgccgacg atggcggttg aagactaccc 2460 tacactgcct actttgccgg atgaaactgg cacgttgcca tcggatgtgt tcgctgaggc 2520 gataggtcag gttgctattg cggccggtcg tgactatacc ttgcccatgc ttaccgggat 2580 ccggatcgag atctcgggtg acacggtagt cttggccgcc accgataggt tccgtttggc 2640 ggtccgcgag ttaaaatggt cggtgttgtc atcggatttc gaggcatcgg tgctggtgcc 2700 ggccaaaact ttggtggaag ttgctaaagc cggtaccgac ggctctggtg tttgtctgtc 2760 attgggcgct ggagtcggcg ttggaaaaga tgggcttttc ggcattagcg gtggcgggaa 2820 gcgcagtact actcgacttc ttgacgctga gtttccgaaa ttcaggcagt tattgccggc 2880 tgagcacacc gcagtggcca ccatcgacgt ggctgagttg accgaggcga tcaaactggt 2940 ggcgttggta gctgaccgtg gcgcgcaagt gcgcatggaa ttcggtgacg gtatattacg 3000 gctttccgcc ggcgccgatg atgtgggccg agccgaagaa gatcttgctg ttgcttttac 3060 tggtgaaccg ttgactatag cgtttaaccc gaattatctg actgatggac ttgcatcggt 3120 gcattcagag cgggtgtcat ttggtttcac gacaccgagt aagccagcat tgctgcgtcc 3180 aacgtctaat gatgatgtcc atccgacgca tgatggcccc tttcccgcac tgccaactga 3240 ctatgtgtat ttactgatgc cagttcggtt gcctggataa gtgtacgtcc ggcattttgg 3300 actgcgtgac tttcggtcct gggaccacgt tgaccttgag ttaaatccag gacggacagt 3360 gtttttcggt cccaatggta acggtaaaac aaatctgatt gaggcactat ggtattccac 3420 cactttaagt tcgcatcggg tggggaccga tataccgtta atcagagcgg gaacaatccg 3480 agctatagtt tcaacgatcg tggtcaatga aggtagggaa tgtgcgattg atttggagat 3540 tgctgcgggg cgggcaaaca gggcgcgatt gaatcgttca cttgtgcgcg gtatgcgtga 3600 ggtagttggg gtattgcgag cggtgctgtt tgcccccgaa gatttagcgt tagtttgcgg 3660 agatcctgcc aatcggcgtc gttacttgga tgatttggcg actgtgcgtc agccggtgat 3720 tgctgccgtg cgcgcagact acgacaaggt gctgcggcaa cgcactgcat tactgaagtc 3780 tttagcagct gcgcggtatc gaagtgacca aggtgtactg gacacacttg atgtatggga 3840 tactcgattg gctgaacatg gcgccgaatt gatggctgcg cgtatcgatt tggtaaatca 3900 gttggcgcca gaagtggaaa aggcgtatca gttgttggca ccgggatcgc gcactgcgtc 3960 gatcagctat cgtgccagtt tagatattgg aggcatcgca ggtgttggga gcagtgaccg 4020 tgccttactg caagccgatc tgttagctgg attgtcgacg cgtcggaacg ttgagttgga 4080 acgcggcata tgcttagtcg gtccgcatcg cgatgaactc gagttgcgac ttggcgacca 4140 acctgcgaaa ggctttgcca gccatgggga atcatggtcg ctggcgatag cgttgcggtt 4200 ggctgcctat gagttgttgc gtgccgacgg taacgaacca gtattgttgc ttgacgacgt 4260 atttgccgaa ctcgatgctg cccgttgtag agcattggcg acagtggcgg aatcagcaga 4320 gcaggtattg gtaacctctg cggcgcagga ggatattccg gtgggttggg atgctaagtg 4380 ggtgactgtc gatttgcgtg acagtgattc gggacgggta tcggtggtgt atccgtgatt 4440 gaatccaatg agtcatatag ctacggtggc gataccatcg aaccactagg cacgttatcg 4500 ggcttcgatt tggttaggcg cgctcttgaa gaagcccgtg ctgcagcctg tgcgcaggga 4560 aaagatgctg gtcgtggaca tgtggtaccc ccagttccgt ttcgtgttac ggatcgacgt 4620 cgtaactggt cgggtccagg gcctgatgtc cgtgatccgc aacctctcgg caaggtggca 4680 catgatctgg cgaaaaagcg cggttggtcg gcgcaagttg ccgagggtag ggtgtttggt 4740 caatgggcgt cgatggtggg cggacaaatt gccgaccatg cattccctgt tggactcaac 4800 aatggtgtac tcagcgtgac tgccgaatcg actgcttggg ctacccagct gcgtataatg 4860 caggcacagt tgctggccaa gattgctgcg gccgttggta atggtgtggt gacttcactg 4920 aaaattacag gcccgaccgc gccatcatgg cgaaaggggc cgtggcacat tgctggcaga 4980 gggccacgcg acacctacgg ctagccgaca cgccggttca gagttgtcaa gatgaaatgg 5040 acttgtatcg ttaatacgag gagaagggga tgctccgtaa atagaaatat cgcctttatg 5100 acgtgatcag gtaagtagaa acagccttat aaaatcggtg tcgacgatcg gtcacgctaa 5160 aatggagtgg tgtgactgct gcggtaactg gaccgctcac atgtaacctc aaggagagca 5220 ttcagaccgt ggctgcccag aggaaggccc aagacgaata tggcgctgcg tccatcacta 5280 ttcttgaagg gctggaggcc gttcgcaaac gtcccggtat gtacgtcggg tcaactggtg 5340 agcgtggtct ccaccatctg atatgggaag tggtggacaa ctcagtagat gaggcgatgg 5400 ccggttatgc tacgcaagtt gatgtgcggt tattcgacga cggtagtgtc gaggtcgccg 5460 ataacggtcg tggtattccg gtggcagtgc atgctacggg ggtaccgact gttgacgtag 5520 ttatgaccca attacatgcc ggcggtaaat tcggtggtaa agatagcggt tataacgtca 5580 gtggtggttt gcatggggta ggtgtgtcgg tggttaacgc attgtccacc agggtcgagg 5640 tcgacatcaa acgtgacggc tatgaatggt cacagtttta cgacaaggct gtgccgggca 5700 ttcttaagca aggcgaagct actgaggcga cgggaacgac gattagattt tgggcagatc 5760 ctgacatttt cgaaaccaca aagtatgact ttgggacggt ggcgcgccga attcaagaag 5820 tggctttctt gaacaagggt ttgacgatca atcttgttga cgaacgggtg aagcaggacg 5880 aagttgtcga cgatgtcgtc agcgatacag ccgaggctcc tgtggctatg accgttgaag 5940 aaaagtcaac ggagtcgagt gcgccgcaca aggttagaca ccgtacgttc cactaccccg 6000 gaggcctggt ggacttcgtc aagcacatca accggactaa gactcctatt caacagagca 6060 ttatcgattt tgatggcaaa ggtgccggtc acgaggttga agttgcgatg cagtggaacg 6120 gcggctattc ggaatcagtg catacctttg cgaacacgat taacacccat gaaggcggca 6180 cccacgaaga aggtttccgt agcgctttga catcagtggt gaacaagtac gctaaggata 6240 aaaaactact caaagacaag gatcccaacc taactggcga cgatatccgt gaaggtctgg 6300 cggcggttat ctcggttaag gtcagtgaac cacagtttga gggtcagacc aaaacaaagc 6360 tggggaacac cgaagttaag tcattcgtgc agagggtctg taatgagcaa cttattcact 6420 ggtttgaagc caatccagta gatgcgaaag cggttgtgaa taaggcgata tcgtcggcac 6480 aagcccgaat agctgcacgt aaagcacgag agttagtgcg tcgaaaaagt gccaccgatc 6540 ttggtggact tcctggaaaa cttgccgatt gccgctctac tgatcctcga agttctgaac 6600 tgtatgtagt ggaaggtgat tcggctggtg gttcagcaaa gagtggccgt gattcgatgt 6660 ttcaggcaat ccttccgtta cgtggcaaga tcataaatgt tgaaaaggca cgtattgacc 6720 gagtgctaaa gaacaccgaa gttcaagcaa ttattacggc attgggtact ggaatccatg 6780 atgaattcga tatctccagg ctgcgttatc acaaaattgt tttgatggcc gacgctgacg 6840 ttgacggcca acatatctcg acgctgttgt tgactttgtt atttcggttc atgcgaccac 6900 tcatcgagca tgggtacgtg tttttagcgc agccgccact ttacaaattg aagtggcaac 6960 gtatggatcc ggaatttgct tactccgata gcgagcgcga cggcttatta gagaccgggc 7020 ttaagcttgg caagaaaatc aacaaagagg atggtatcca acgttataaa ggtttaggtg 7080 aaatggatgc caaggagttg tgggaaacca ccatggaccc gtcggtgcga gttttgcgtc 7140 aagtaacact ggatgacgcg gcggctgctg acgagttatt ctctattctg atgggtgagg 7200 acgtcgatgc acgccgtagc tttatcaccc gtaatgccaa ggatgttcgt ttcctggatg 7260 tctagttaaa taaaacattt ttcgacgtgc gatgcaaatg atgcaaatga ggaataaatg 7320 actgatatca cgctgccacc aggtgacggt tctatacagc gggttgagcc ggtcgacatt 7380 cagcaggaaa tgcagcgcag ctatattgat tacgcgatga gtgtgattgt gggccgggcg 7440 ttgcctgaag tccgcgatgg tctcaaaccg gtacatcgtc gggtcttgta cgcgatgtta 7500 gactccggtt tccgcccgga ccgtagccac gctaagtcag cacggtcagt cgctgagacg 7560 atgggcaatt accatccgca cggcgacgca tcgatttatg acacgttagt gcgcatggcg 7620 cagccgtggt cgctgcggta tcccttggtt gatgggcaag gcaatttcgg ttcgccgggt 7680 aatgacccac cggcagcgat gcgttattgt gtgtcaggaa attccttggt gaggttgcta 7740 tttgggaaat caatacgaat cggtgatatc gttactggag ctcagttcaa ttcggacaat 7800 ccgatcgact tgaaggttct tgatcggcat ggtaatccgg ttgtagccga ttatttattc 7860 cattcaggag agcaccaaac ctatacagtg cgcaccactg aaggctatga gatcaccggg 7920 acgtcgaacc atcccttgtt gtgtttagtg aatgtcggcg gtatacccac cttgttgtgg 7980 aagctgattg gagaaattcg atcaggagac tacgttgttt tacagcggat cccaccagtg 8040 gaatttggtc cggcggactg gtattctacg atggaagcat tgttattcgg agcctttatt 8100 agtgggggct tcgtttttca ggaccatgct ggatttaaca gccttgaccg tgactatttc 8160 accatggttg ttaatgctta tgatacggtt gtgggtggcc tgcgttgcat atcttctcga 8220 atcaccgtat cggggtcgac gctactcgaa cttgatgttt ataacctcat cgagtttaag 8280 aagacaagac ttagcggttt atgcgggcaa cggtctgcgg acaagttggt acctgactgg 8340 ttgtggcact caccttccac cgtcaaacga gcattccttc aggcattgtt tgaaggtgaa 8400 ggattttctt cgatattgtc gcgaaatata attgagattt cctactcgac acttagtgag 8460 cgactggccg ccgacgtcca gcagatgctg cttgaattcg gagtcgtgtc tgagcgctat 8520 tgccatactg tcaatgagta caaggttgtc atagctaacc gcgctcaagt agaaatgttt 8580 ttcacccaag tcggtttcgg tgttactaaa caagctaagc ttatccggga cgtggtatct 8640 atgtctccat gcgttggcat ggatatcaac tgcgtaccag gtttggccac tttcattcgt 8700 aagcattgtg ataaccgctg ggtcgaggaa gactcattta atcagcataa tgttgattgc 8760 gtccaacatt ggcaccatca tagcgcggaa atcgtcggcc acatcgccga tcccgatatt 8820 cgtgccatcg tgactgacct tactgatggc cggttctact acgcgcgcgt cgcgtccgtg 8880 actgataccg gtattcaacc tgtgttcagt ctacatgtgg acaccgagga tcattcgttt 8940 ttgactaatg gattcatcag ccataacacc gaggctcggc ttactccatt ggcgatggaa 9000 atgttgcgcg agatcgacga ggagacagtt gatttcatat ctaactacga tggccgggtg 9060 caggaaccga tggtgttgcc tagccgtttt cccaacctgt tggctaatgg ttctggcggt 9120 atcgcggtcg gcatggctac caatatcccg ccgcacaacc tgtatgagct cgccgacgct 9180 gtgttttggt gcctagagaa ccatgacgct gacgaagaga cgatgctggt cgctgttatg 9240 gaacgggtca aaggtcctga tttccctacc gccgggttga ttgtcggttc gcaaggcatt 9300 gccgatgctt acaagactgg ccgtggttcc attcggatac gcggagttgt tgaggttgaa 9360 gaagattcac gcggaaggac gtcattggtc atcactgagc taccgtatca ggtcaaccac 9420 gacaacttca tcacttctat cgctgagcaa gtccgcactg gccggctagc cggcatctcc 9480 aatgtagaag accaaggcag cgaccgggtt ggtgtacgta tcgtcatcga gatcaagcgt 9540 gacgcggtgg ccaaagtggt gctcaataac ctgtacaagc atactcagct gcaaactagt 9600 ttcggagcca acatgttgtc aatcgttgac ggcgtgccgc gcactttgcg gttggatcag 9660 atgatttgtt attatgtcga acatcaactg gacgtcattg tccggcgcac tacctaccga 9720 ttgcgtaaag ccaacgagcg ggctcatatt ttgcgtggat tggtcaaagc gctcgatgcg 9780 ttagatgagg ttattacgtt gattcgggca tcgcagaccg tggatattgc tcgtgttggg 9840 gtggtcgagt tactcgatat cgacgacatt caggctcaag ctatcctgga catgcagctg 9900 cggcgtttgg cggctttgga gcgtcaacgc attattgatg atctcgctaa gattgaggtc 9960 gagatcgctg atctgggaga tattctggct aagccggagc gtcggcgtgg tatcattcgt 10020 aatgaactga ctgagatcgc agagaagtac ggtgatgacc gtcgtactcg gataatagcg 10080 gttgatggtg atgtcaacga cgaggatttg attgctcgtg aagaggtcgt tgtcacgata 10140 actgaaactg gatatgctaa acgtactaaa actgacctgt atcgcagcca gaaacgcggc 10200 gggaaaggtg ttcaaggcgc cggtttgaag caggacgaca tcgtccggca tttcttcgtg 10260 tgttcaactc acgattggat cctgtttttc accacccaag gccgcgtata ccgggccaag 10320 gcctatgaat tgccagaggc ttctcgaacg gcacgcgggc aacacgtggc caatttgctt 10380 gcattccagc ctgaagagcg catcgctcag gtaattcaga tccgtagcta tgaagacgct 10440 ccatacttgg tccttgccac gcgcgccggt ctggttaaga agtcaaagtt gaccgatttt 10500 gactctaatc gttcgggtgg gatcgtggca attaatttac gtgacaacga tgagttggtc 10560 ggtgcagtgt tgtgcgcggc cgacggcgac ttgcttctgg tatcggctaa cggccagtct 10620 atccggttct cagcgactga cgaggccttg cgtccgatgg ggcgggctac ctctggtgtg 10680 cagggcatgc ggtttaacgc cgatgatcga ctgttgtcgt tgaatgtggt tcgcgaagat 10740 acttacctgc ttgtcgcaac gtctgggggt tacgctaaac gcacctcgat tgaggagtac 10800 ccgatgcagg gccgtggcgg aaagggtgtt ctaacggtca tgtacgatcg tcggcgcggt 10860 agcttggttg gggccatcgt ggttgatgaa gacagcgagt tgtacgcgat cacctcaggg 10920 ggtggggtaa ttcgtacaac ggcacgccag gttcgccagg caggacgcca gaccaagggt 10980 gttcggttga tgaacttagg tgagggcgac acgctgttag ccatcgcacg taatgccgaa 11040 gaaagcgccg acggcggtgt cggttaaagt gatgatctca aggagtcgtg tacttagctt 11100 ttttggttcc gatagcaata cttcgcccga ccggacatga ttgtgactgg ctacatactc 11160 gggcagattg atacacatgt tttaaggagt cggggtgacg tcaccgaacg aatcgagggc 11220 cttcaacgcg gccgacgacc tgattgggga tggttcggtc gagcgtgccg gtctacatcg 11280 cgcaacgtct gtaccgggag agtcatcgga gggtctccaa aggggccaca gcccggaacc 11340 caacgattca ccgccctggc agcgtgggtc cgcccgagct tcccagtccg gttatcgccc 11400 gtcagatccg ctcaccacta cacggcagtc gaatccagca ccaggtgcaa acgtccggtc 11460 gaaccgcttt atctccggca tgactgcacc ggcgctgagc ggacagctgc ccaagaagaa 11520 taactcaaca caggcattgg aacctgttct gatgtctaac gaggttccat tcactgaatc 11580 gtacgctagc gagttaccag atttgtccgg accagtccag aggaccgtac cgtgcaagcc 11640 ctcgcccgat cgtggttcca gcacaccgcg gatgggacgt ctagagatta ccaaagtgcg 11700 aggaaccggt gaaatccggt cccaaatatc gcgccgaagc catggaccgg ttcgggctag 11760 catgcagatc cggcggattg atccatggag catgttgaag gtgtccctgt tgctctcggt 11820 tgcgttgttc tttgtctgga tgatcgcggt ggcgttccta tacttattgc tcggcggtat 11880 gggggtgtgg gcaaagctca acagtaacgt tggtgatctt ctaaacaaca ccggcggaaa 11940 tagcggagaa cttgtctcca acagcaccat cttcggttgt gccgtcttgg tcggcttagt 12000 caacattgtg ttgatgacta cgatggccgc tatcgctgcg tttgtctaca atttgtcctc 12060 cgatttggtc ggcggtgttg aagtcactct cgcagattta gattaggttg tggcgatgtt 12120 gtttgagggt tcgttttttg gggtgaggtt ctaataactg cggtaatctc gttgctcggt 12180 tatacgcaag taagggccta tagctcaggc ggttagagca cttcgctgat aacgaagagg 12240 tcggaggttc gagtcctcct aggcccacaa ctatgtgtac gtcaagatgt tgtgtgaaat 12300 ttgcgttctt gctggtctcg gtcgctgtgg tggtagtagt gcagtcacga cacggcgttg 12360 gagtttggaa cgtggcggca tttggcatac tcgataatga cggggggcct tagctcagtc 12420 ggtagagcac tgcctttgca aggcagatgt caggggttcg attcccctag gctccacaaa 12480 cacaaccaca gctagacagt ggtctgcaac ttcggaattt ccgaggtttt gaggggtcag 12540 gcgtgattac attttaacca caatcgcgag ttaacagcgc attgatggcc atctagaccg 12600 cctcgatatt ccgtccgtat agaagttata agttgattca acatcagctc agcaggatcc 12660 agggaaagct gctacgctcg gaccgcccgg caccaggagc tcgtcgacaa acgttggcga 12720 gctgatcgtg ttcgccttgc tgctcttcag tgacctcacc acaaacacgt cgtctaccag 12780 tgtcagtcga cctcggcatc cacacctgcc gattgtcggt gactgctatt gcgagcaact 12840 gcctaatagt accaactatt ttgtgtatcg aagacagttg cccgatctac attcagaccc 12900 gtaacttact cgcgaacaaa tcgctgaccg agatagccca acaccgtatt cagtattatc 12960 tgatattggg cgcgaataga cttcttcatc agtttgtgct tggagtcgag ctatatctgt 13020 gtttactcct tcagctttac tggactggtg gccggcgtta taggccaacg cggcgctgtt 13080 tacctcaagc tgattcgccc acgttctgat aagaacgctt ggtcggaaag ccttgcttcg 13140 ttgtttgacg acgaccgtca ggagtcttgt actgtggtct gatattggat tgcataactt 13200 gaggtttctt accgttctaa ttgttgccat aagtgttttg tcggactgat ctcaactgga 13260 tggtcttgac cgatactcta ggcaaaagtg tttcgtcctg taacttatcc ctgacgaact 13320 gttttctgca gttcggatag ctcggtcgcc ttaccttctt gacctttctg ccatgatctg 13380 aggctaatat cactgcttga tttacgaaag attgttgtta agatatacta gttaataagt 13440 gcggctgacc tcggtgctgt ggcagtggtc cttgatgttt ggcctgttgg gaaaatgtta 13500 atggatatac gtgctgttta cgcttcgtta ctgtagggct gaatgccgta caaaatcaaa 13560 aaatgtattg gcgaacaact tatttaggtt tagtaggttg tttatagtta ataatatgct 13620 acaagcacgg ttgtactact agtggtgttt agtcacccta cttgactgga caaggagaat 13680 tttttagcag ggaaatatat tctttgtgca aattttcgtt ctggatgaac ttttgccgta 13740 gatagatcta ttttaatctg ctggagagct tctcatgaga ttatgtgtgt tcaccggtac 13800 cgtagacgct ggtggcgacc attatatgtt ggtggtaatg ttggtcatta ttgttacgtc 13860 tgccgttacg acggcgatat gcgacttgct tggcagtttt tattacccac ttaagcatgt 13920 ttttgccacg aaatgcggac gcttcgtaat tatttatttg tcctaacggg acaccacctc 13980 gtgatttgtc ttaccgacaa tagtcattaa tcctccgtca cgggtttgtc gtcacagatc 14040 aactcttgtc cgaccctatc gatctatggc ttccggttgc ttactcatct ataccagtat 14100 ttcctaattt tctttgggat taattgcaag atttcgatca ggttatttgg tatgtgctag 14160 cagattaatt cgtaattccg gatatgcatc ttttgagcta gactaggaga atatatacat 14220 acatacatat atatatatat agatgtaaat cttcgaactt gtaatttaga gccgataaag 14280 tacgggtcat ctggcgcaga tagacagttg agtatgcgtg ttgattgatt ttttacaaca 14340 tgaagtaagc tgaggttaat ttctgaacct gatcggtatt tctggtataa aattcttttt 14400 tacacacgtc tatcacctaa aaatgctctt ctagtgtgga tgagtttcat gtttgtaaat 14460 gggtcagtgg atagcttggt tgggtaattt ccaggtcttg tgcggataaa attcctgcgg 14520 cacctgaaat ggaatgctgg tgagagcttc acgcggcgta tagcgaccag atcccccatc 14580 tgagtgaagt acgaattcgt tgaacagtct cgtaaccgtg ttttcgacga agtactttat 14640 tgtgttaaca acgctgccgg tcttctaatg gagacctgag aatagacttt tccaagcctt 14700 cattaaggct agcatgcatt gtttattacc actttattca tatataatta tgatttcatc 14760 tggctgctta atggaagcct ggaataaatg ttgaaatatt gtgatttaag ccatgtcgaa 14820 ggtgtcctgg gaagacctcc acgtgggttt ttgttggttg attataattc gaaagtcccg 14880 tactccaata tggttctcat ctgtgcagga atcgaaagaa aatccagtaa ctaatatgtt 14940 gatagttcgg tttgaaaaaa ttcagtgttc ggaggtgaaa ttacacatat aagaaggcta 15000 atcttaattt atttccagac atcgatgccg tattttaccc ggatttttca ctgtagatct 15060 aaaatcatag cgaagggatc tggtcattta tcattttcaa caaaaagcat cctaaaccac 15120 aacagttgga tgatttaaca aaagctggat caccagtttt ttaggtctca tcgatataca 15180 caagaatcac atttctgaag gttatgacca gacaagtgcg aaagtagcca ctttccgtac 15240 acagttaaaa atttgttaac cacagttgtt tttcacattt gatcctagat ataatttttc 15300 actttatagt ataattaacc tttgcaagac aggtgtcaaa gatgcgattt ccttaggttc 15360 tacaaaatct tgaaacctgc tacggacgct tgacaagaac gaatgttcac ttacagccat 15420 agctatacgt cgaagctggc tgggcgaggt gacagctccg aacgcaatga gcaccagata 15480 gtgctaaaaa ccatttcaac accggccagg actgactatg ctgatcgtac cgatcataca 15540 agggtagctt ggtgttgcgg tcggtgttct tgtcgcaaca cctgcggcag gtttgcgact 15600 actgcctgcg cggctgccag ctcctaggtg actgtttcct ggatggaagc aaagtatgga 15660 agcaaagttt ggaagctagt ccgccttcct tgagcttgag gcggtcgacc gcaaggtaat 15720 gagacttaaa gtccaacagt gccttgtgtg acatctacca gtcccagtgg ccgagtaggt 15780 caggccttgg gtcagtagtt ctcgagaggt tagccgcgtt tccgtctaca cgtttatcca 15840 ccgcttttct ttgcctctta cgaatcgata cctctcccag cctgccatca cctaaaaacg 15900 cccatagttc tattacatgc acactggtcg tatagcgctg cgacaatagc taggtttcat 15960 gtgacaccgg atgtgaacgt actggtgagt taatggcaca ctgtgatttt gtgaccaaca 16020 gccttattca gaatgccact gccacgttac acac |