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EBI DbfetchID AL513383; SV 1; circular; genomic DNA; STD; PRO; 218160 BP. XX AC AL513383; XX PR Project:236; XX DT 26-OCT-2001 (Rel. 69, Created) DT 13-MAY-2009 (Rel. 100, Last updated, Version 7) XX DE Salmonella enterica subsp. enterica serovar Typhi str. CT18 plasmid pHCM1 XX KW . XX OS Salmonella enterica subsp. enterica serovar Typhi str. CT18 OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Salmonella; OC Salmonella enterica subsp. enterica serovar Typhi. OG Plasmid pHCM1 XX RN [1] RP 1-218160 RX DOI; 10.1038/35101607 RX PUBMED; 11677608. RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., RA Churcher C., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T., RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M., RA Rutherford K., Simmonds M., Skelton J., Stevens K., Whitehead S., RA Barrell B.G.; RT "Complete genome sequence of a multiple drug resistant Salmonella enterica RT serovar Typhi CT18"; RL Nature 413(6858):848-852(2001). XX RN [2] RP 1-218160 RA Parkhill J.; RT ; RL Submitted (25-OCT-2001) to the EMBL/GenBank/DDBJ databases. RL Submitted on behalf of the Salmonalla sequencing team, Sanger Centre, RL Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA E-mail: RL parkhill@sanger.ac.uk XX DR GR; AL513383_GR. DR RFAM; RF00240; RNA-OUT. DR Sample; ERS000058. XX CC Notes: CC Details of S. typhi sequencing at the Sanger Centre CC are available on the World Wide Web. CC (URL, http://www.sanger.ac.uk/Projects/S_typhi/) XX FH Key Location/Qualifiers FH FT source 1..218160 FT /organism="Salmonella enterica subsp. enterica serovar FT Typhi str. CT18" FT /plasmid="pHCM1" FT /strain="CT18" FT /mol_type="genomic DNA" FT /db_xref="taxon:220341" FT CDS complement(join(218131..218160,1..528)) FT /transl_table=11 FT /gene="HCM1.01c" FT /product="putative membrane protein" FT /note="HCM1.01c, possible membrane protein, len: 185 aa; FT unknown function, contains hydrophobic, possible FT membrane-spanning regions. Spans sequence end" FT /db_xref="UniProtKB/TrEMBL:Q935S6" FT /protein_id="CAD09619.2" FT /translation="MNQTETGPSGFTETTVDEERIAIRVMIGDVVGRYRKQVPPDRVQK FT ATFEVNGGLLMALLLALLMLVCIIQRLATGDRLMSFTGEPDVRDIQFTLMLVIEFALGM FT VVWFLIATGEFSRPWLYRLTPAKPVWLFDEVEDADLVLLSGNPFIKRWLHKEILKIRRL FT TYTRLDEELEKIAPLPGQPPAQ" FT RBS complement(536..540) FT /note="possible RBS" FT CDS complement(742..1053) FT /transl_table=11 FT /gene="HCM1.02c" FT /product="hypothetical protein" FT /note="HCM1.02c, hypothetical protein, len: 103 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935S5" FT /protein_id="CAD09620.1" FT /translation="MMYPDITGVKMKLSQLEVGMTVWSLSRTKMGNTTIKTVTLHSVVI FT KEVHDNHVIASWNGNAPRRFGETAITGWKKEKPLLIRDRSGSARLATREEKARILDTK" FT CDS complement(1367..1690) FT /transl_table=11 FT /gene="HCM1.03c" FT /product="hypothetical protein" FT /note="HCM1.03c, hypothetical protein, len: 107 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5P4" FT /protein_id="CAD09621.1" FT /translation="MNKPLVSFAELSGNAINVARQSVIDMEMDATREKIGKARSLFHSG FT IHRAVNGYPLIQSAANQLAVIKRLLGDTKYLDACITENLCMFSPEGYLYLFMQRRFINE FT PVA" FT RBS complement(1697..1702) FT /note="possible RBS" FT repeat_region 1871..1883 FT /note="13 bp inverted repeat flanking IS1" FT repeat_region complement(1871..2585) FT /note="IS1" FT CDS complement(1876..2346) FT /transl_table=11 FT /gene="insB" FT /gene_synonym="HCM1.04c" FT /product="putative IS1 transposase" FT /note="HCM1.04c, insB, possible IS1 transposase, len: 156 FT aa; highly similar to many from Enterobacteriaceae e.g. FT SW:ISB_ECOLI (EMBL:D10483), insB, Escherichia coli FT insertion element IS1 protein InsB (167 aa), fasta scores; FT E(): 0, 91.6% identity in 167 aa overlap" FT /db_xref="GOA:Q935S4" FT /db_xref="InterPro:IPR005063" FT /db_xref="UniProtKB/TrEMBL:Q935S4" FT /protein_id="CAD09622.1" FT /translation="MPGNRPHYGRWPQHDFTSFKKLRPQSVTSRIQPGSDVIVCAKSRQ FT RWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLH FT VISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ" FT CDS complement(2265..2540) FT /transl_table=11 FT /gene="insA" FT /gene_synonym="HCM1.05c" FT /product="putative IS1 transposase" FT /note="HCM1.05c, insA, probable IS1 transposase, len: 91 FT aa; highly similar to many from Enterobacteriaceae e.g. FT SW:ISA1_ECOLI (EMBL:X52534), insA, Escherichia coli FT insertion element IS1 protein InsA (91 aa), fasta scores; FT E(): 0, 98.9% identity in 91 aa overlap. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). Contains probable FT helix-turn-helix motif at aa 67-88" FT /db_xref="GOA:P0ADH1" FT /db_xref="InterPro:IPR003220" FT /db_xref="UniProtKB/Swiss-Prot:P0ADH1" FT /protein_id="CAD09623.1" FT /translation="MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY FT TASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNSGRSR" FT misc_feature complement(2284..2289) FT /note="possible translational frameshift site, similar to FT that determined experimentally (EMBL:X52534)" FT misc_feature complement(2472..2495) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT repeat_region complement(2573..2585) FT /note="13 bp inverted repeat flanking IS1" FT CDS complement(2694..3644) FT /transl_table=11 FT /gene="corA" FT /gene_synonym="HCM1.07c" FT /product="putative magnesium and cobalt transport protein" FT /note="HCM1.07c, corA, probable magnesium and cobalt FT transport protein, len: 316 aa; similar to many e.g. FT SW:CORA_ECOLI (EMBL:L11042), corA, Escherichia coli FT magnesium and cobalt transport protein (316 aa), fasta FT scores; E(): 0, 99.1% identity in 316 aa overlap. Contains FT Pfam match to entry PF01544 CorA, CorA-like Mg2+ FT transporter protein. Contains hydrophobic, possible FT membrane-spanning regions" FT /db_xref="GOA:Q9L5P6" FT /db_xref="InterPro:IPR002523" FT /db_xref="InterPro:IPR004488" FT /db_xref="UniProtKB/TrEMBL:Q9L5P6" FT /protein_id="CAD09624.1" FT /translation="MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRLQSE FT LGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTL FT RERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIM FT EGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRD FT IESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFE FT FMPELKWRFGYPAAIIFMILAGLAPYLYFKRKNWL" FT misc_feature complement(2697..3584) FT /note="Pfam match to entry PF01544 CorA, CorA-like Mg2+ FT transporter protein, score 432.90, E-value 2.8e-126" FT RBS complement(3653..3656) FT /note="possible RBS" FT RBS 4004..4007 FT /note="possible RBS" FT CDS 4014..4343 FT /transl_table=11 FT /gene="HCM1.08" FT /product="hypothetical protein" FT /note="HCM1.08, hypothetical protein, len: 109 aa; similar FT to the N-terminal half of SW:YIGE_ECOLI (EMBL:L02122), FT yigE, Escherichia coli hypothetical protein (254 aa), fasta FT scores; E(): 0, 97.9% identity in 95 aa overlap" FT /db_xref="InterPro:IPR018711" FT /db_xref="UniProtKB/TrEMBL:Q935S3" FT /protein_id="CAD09625.1" FT /translation="MAHQLLIGKGMITLNLKRIFLALTLLPLFAVAADDCALSDPTLTV FT QAYTVNPQTERVKMYWQKANGEAWGTLHALLADINSQGQVQMAMNGGILNLTVFDIKYR FT KKEVF" FT CDS complement(4363..4569) FT /transl_table=11 FT /gene="HCM1.10c" FT /product="hypothetical protein" FT /note="HCM1.10c, hypothetical protein, len: 68 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5P8" FT /protein_id="CAD09626.1" FT /translation="MGHVDYTRTLRVQLYDASRFHDGATAEQAGELHTVAFSKPAIADD FT IQKIVDTTAEVLGKRYSVNVFSN" FT RBS complement(4577..4581) FT /note="possible RBS" FT CDS complement(4604..4828) FT /transl_table=11 FT /gene="HCM1.13c" FT /product="hypothetical protein" FT /note="HCM1.13c, hypothetical protein, len: 74 aa; unknown FT function. Similar to HCM1.30c, hypothetical protein (74 FT aa), fasta scores; E(): 8.7e-18, 57.1% identity in 63 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q9L5P9" FT /protein_id="CAD09627.1" FT /translation="MHNLEISTIAIFSAQYKNIEEAENAGALYSVDIEYPMTLNDLSLL FT CESVAKAVGVPNGVKYQFVTQPQPEESDY" FT RBS complement(4836..4840) FT /note="possible RBS" FT CDS complement(4882..5088) FT /transl_table=11 FT /gene="HCM1.15c" FT /product="putative membrane protein" FT /note="HCM1.15c, putative membrane protein, len: 68 aa; FT unknown function. Contains hydrophobic, possible FT membrane-spanning regions" FT /db_xref="UniProtKB/TrEMBL:Q935S2" FT /protein_id="CAD09628.1" FT /translation="MKLFYSKPVRFIVIICVFLLGVDNLSDMFVDISRPVFYGGLAALL FT AAAVVIARVDYNKNAEKKASQVH" FT RBS complement(5098..5102) FT /note="possible RBS" FT CDS complement(5484..5744) FT /transl_table=11 FT /gene="HCM1.17c" FT /product="hypothetical protein" FT /note="HCM1.17c, hypothetical protein, len: 86 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5Q1" FT /protein_id="CAD09629.1" FT /translation="MVIDAENSEMHQVRDFIAANWSLFTSHIREKSMTDEQAEEEAQRI FT FVVVGGGRVKAFASLRDSARCWICTLFSGLSANLSAGQPSL" FT RBS complement(5753..5756) FT /note="possible RBS" FT CDS complement(5833..6324) FT /transl_table=11 FT /gene="HCM1.20c" FT /product="hypothetical protein" FT /note="HCM1.20c, hypothetical protein, len: 163 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935S1" FT /protein_id="CAD09630.1" FT /translation="MTTLTFEIAGVKKLLEELRSAERFNATIEQLFEPSNYPGGTPLNE FT EGKTEVEMNQTGGIFWPSSKHIDPARLTPQILLVKDHGVYLITNASLDGTPVSRDTVVY FT ARGMNPSVDDEWYDEAEEALGGDDSSVSIPVAWFELALKKKFNAFSIKVSPTKITLVNG FT " FT CDS complement(6329..6637) FT /transl_table=11 FT /gene="HCM1.21c" FT /product="hypothetical protein" FT /note="HCM1.21c, hypothetical protein, len: 102 aa; shares FT a region of similarity with TR:Q9X5P0 (EMBL:AF127177) FT Escherichia coli hypothetical protein (208 aa), fasta FT scores; E(): 0.00012, 34.9% identity in 83 aa overlap and FT TR:O85616 (EMBL:AF071034), L0009, Escherichia coli O157:H7 FT hypothetical protein from a pathogenicity island (65 aa), FT fasta scores; E(): 0.00047, 43.1% identity in 58 aa FT overlap" FT /db_xref="InterPro:IPR009301" FT /db_xref="UniProtKB/TrEMBL:Q9L5Q3" FT /protein_id="CAD09631.1" FT /translation="MQINKVMSLLDILTSWLEDNINMESDLFFDNDVDNTTSESLYPAV FT EKANAVLSKLASLSSETIQATRQRLQDAVEGKGEVSTADVKELLLATRYLMLTTDGE" FT RBS complement(6334..6337) FT /note="possible RBS" FT CDS complement(6845..7225) FT /transl_table=11 FT /gene="HCM1.22c" FT /product="putative membrane protein" FT /note="HCM1.22c, possible membrane protein, len: 126 aa; FT unknown function, contains hydrophobic, possible FT membrane-spanning regions. Contains PS00044 Bacterial FT regulatory proteins, lysR family signature" FT /db_xref="UniProtKB/TrEMBL:Q935S0" FT /protein_id="CAD09632.1" FT /translation="MKFILMFFILAILIWGFTGLTFKDAILFTSVGLSISVVALSALLV FT VALTFVMAAMYAAHELGSLGKMIISQVVLVGFWNLIFSVIPDGKLISFFGVNVWQSGSY FT LVYFMTVLVAVFAAYIALQKQR" FT misc_feature complement(7088..7180) FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS complement(7312..7596) FT /transl_table=11 FT /gene="HCM1.23c" FT /product="hypothetical protein" FT /note="HCM1.23c, hypothetical protein, len: 94 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935R9" FT /protein_id="CAD09633.1" FT /translation="MVPFCHKLEEKLMTSNRCREIKTPPEHIIADYILRFMKNNKEAKL FT YEAMSRLESKINLFVADGHDELHIRALLNQAAHSHTKESLKQACERICN" FT CDS complement(7598..7918) FT /transl_table=11 FT /gene="HCM1.24c" FT /product="hypothetical protein" FT /note="HCM1.24c, hypothetical protein, len: 106 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935R8" FT /protein_id="CAD09634.1" FT /translation="MIPFFILKDISLVTRFSIINLNPIHSITCKDMNMDKYLALDRALN FT EILTPVPTPFSTLFAGEIKAECHRIAAGESNPQPSHILDRRLLALCKAGQINYTTGKGW FT LK" FT CDS complement(7995..8348) FT /transl_table=11 FT /gene="HCM1.25c" FT /product="hypothetical protein" FT /note="HCM1.25c, hypothetical protein, len: 117 aa; unknown FT function. Contains PS00044 Bacterial regulatory proteins, FT lysR family signature" FT /db_xref="UniProtKB/TrEMBL:Q935R7" FT /protein_id="CAD09635.1" FT /translation="MSLLRLTDISMDIYDMTEKEVRMDEDKVLSFINSGDGDAGDLLDD FT AMPTAARRFYRLTQSMHTLLGEVREHFPDAMFYSANGKVSLLLGSSHNKHDQPMQEMVA FT VSATQLHIEGGDW" FT misc_feature complement(8121..8213) FT /note="PS00044 Bacterial regulatory proteins, lysR family FT signature" FT CDS complement(8364..8972) FT /transl_table=11 FT /gene="HCM1.26c" FT /product="hypothetical protein" FT /note="HCM1.26c, hypothetical protein, len: 202 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935R6" FT /protein_id="CAD09636.1" FT /translation="MFLHLVPKILHPMGNLCTLDSVSVPELSLRLTGNDLVAMRPYPNK FT QYLVGMLKGRRALNGFLVKSPRAFEEFTMVSVWNIEGFGKITHTLKTFVEDTDYDLVSH FT DVLLAQGSYRAQASEQCRVHPVYKNIAPVHIEPKMESLLSTEPNFENDVCETHSWGMLV FT RSRDEGFKAMTMPSARLQESVALRGDRQPQLEQAIVITG" FT RBS complement(8980..8984) FT /note="possible RBS" FT CDS complement(9003..9527) FT /transl_table=11 FT /gene="HCM1.27c" FT /product="hypothetical protein" FT /note="HCM1.27c, hypothetical protein, len: 174 aa; unknown FT function" FT /db_xref="GOA:Q935R5" FT /db_xref="InterPro:IPR002711" FT /db_xref="InterPro:IPR003615" FT /db_xref="UniProtKB/TrEMBL:Q935R5" FT /protein_id="CAD09637.1" FT /translation="MKVLNNKGAVIELPNFSELLPKVESDDGRFSKPKNKISKEQRAEL FT RLKFGGRCAYCGCPLPEKGWHADHVEPVRRDFEMVRAPAGSRVTHRARSTGKVMHPELH FT AIENLFPACAPCNLFKGALSVEGMRKEISRQVERARAYSVNFRTAERFGLIEVTEKPVV FT FWFEIHQATAQ" FT CDS complement(9558..9869) FT /transl_table=11 FT /gene="HCM1.28c" FT /product="hypothetical protein" FT /note="HCM1.28c, hypothetical protein, len: 103 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935R4" FT /protein_id="CAD09638.1" FT /translation="MNNEMSSLGTQKAEGPFVLLTLVGEGFIFDERHEIVRINGRPKQI FT GVKRNYFESDLGEGKAKYWTLDINEAHVFPTLDAATEQLCKLSRPHLIKIRKLIQENK" FT CDS complement(9866..10597) FT /transl_table=11 FT /gene="HCM1.29c" FT /product="hypothetical protein" FT /note="HCM1.29c, hypothetical protein, len: 243 aa; shows FT weak similarity to TR:O03965 (EMBL:U64984) Myxococcus FT xanthus bacteriophage Mx8 hypothetical protein (222 aa), FT fasta scores; E(): 2.6e-06, 36.4% identity in 242 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q935R3" FT /protein_id="CAD09639.1" FT /translation="MCEPCVKGVSTVKTRGMLFNDEMVRAILADQKTQTRRIIKPQYSS FT DEWSIRPAQTPRHRGHTHDWWLPTGTQPYSALRPCPYGVVGDRITVREAFSLLGNEDAC FT AVDWNDNIVMDRTEAARIYRASCEQRSGDYGLWSIPDEADWKPRTENMKFEGAWTPSIH FT MPRWASRIALEITDLRVERLNTISEEDAKAEGAPTECCVLGDKHFLGFRSLWKNTYGED FT SWQANPWVWVVNFKRITGEVV" FT RBS complement(9873..9878) FT /note="possible RBS" FT CDS complement(10705..10929) FT /transl_table=11 FT /gene="HCM1.30c" FT /product="hypothetical protein" FT /note="HCM1.30c, hypothetical protein, len: 74 aa; unknown FT function. Similar to HCM1.13c, hypothetical protein (74 FT aa), fasta scores; E(): 1.3e-16, 57.1% identity in 63 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q9L5Q9" FT /protein_id="CAD09640.1" FT /translation="MPIQEKTTVFVFNACHADKAAAASANALHSLEVEYPMTLNDLSLL FT CESVAKALDVPGGVKYEITTEPVVDGEYD" FT RBS complement(10938..10941) FT /note="possible RBS" FT CDS complement(11016..11480) FT /transl_table=11 FT /gene="HCM1.31c" FT /product="putative membrane protein" FT /note="HCM1.31c, possible membrane protein, len: 154 aa; FT unknown function, contains hydrophobic, possible FT membrane-spanning regions" FT /db_xref="UniProtKB/TrEMBL:Q935R2" FT /protein_id="CAD09641.1" FT /translation="MTDIKEKQNHFSKLKCIAISWHFNKPTGKEHLLLFVAIVAWIFPG FT LVFFKHSLWGGLLFFFFVAGSYAFLAFPHFTHRKKIWKERLDQSLKEYQPLDLQAWAYF FT KDRVREEGMTYKACESWMSTEASALYKSPKQEWSFLDSTSVGENDKSQPD" FT RBS complement(11488..11493) FT /note="possible RBS" FT CDS complement(11663..14092) FT /transl_table=11 FT /gene="HCM1.32c" FT /product="hypothetical protein" FT /note="HCM1.32c, hypothetical protein, len: 809 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935R1" FT /protein_id="CAD09642.1" FT /translation="MDLINIATIQRKPNSGNNMYIEMKETFLELPSEIQFSEAANAAIL FT TQDKWGDVWQTLKTDADLNYTDAGEPVSLASRVTTATSAIYHAITEGWTMCVGYSGGKD FT SHSLLHLFLMALIRAVRNGSNVSQHHFIQMSDTLIENPEMHHQATQVLSQLRAFIAEQE FT LPLTVLVARPSMTQSWVGRILTGRGLPTWTNSSTRQCATDLKRSPLRQAKARYLKNAPA FT SVRNKVCLMLGSRDDESARRADNILRMGGQADSVSLTEHGGELYPVKEWRAQDIWSFLM FT ACGSLARFPLPSFLPDNFSLATLYKDATGECIWTPEKSTVRSSACGARYGCSLCCAVGI FT DHSMETLLRTDPEKYGYQAGLNRLQRFLTKIQYDWSLRDYIGRKVFEGGYVRLQPNVFS FT SSLTERLFHICCSLDYVEAQRAAAVHEKLLSGEIEDTAHNRRMSEPQFRLVQEANVLHI FT DFLWSLHCFNPRPFRAIELYRQVWEGGALDLLDDEPAMQPVPRTPMPAPRWMKLPEGRI FT GTSFDGLSDPSSEIAYFDGREDERASRSLMSSGEGLNIVAFEEEDELTVDEDTASWIIW FT HEYDGLRQRVSDGEFTPVAAAQYLLRYGAVRISRGKGAVYHRLAQRGQAYSRLGINDQT FT PLPSLLASRRFKILTDSDYRLLVARKLRGQRQKLRFWCCVAACVALHTYNKTPLGGWIT FT TQLETEQQLHLARTGDELKARTLDAVLTLCNLRISSQQPEERLYYRAVRKRFLETLAGC FT ISPEREGTLREVIWELRMLSGPQSSKKTGFRHVDECRERTAALLRPLLKRMVRLLA" FT CDS complement(14215..14727) FT /transl_table=11 FT /gene="HCM1.33c" FT /product="hypothetical protein" FT /note="HCM1.33c, hypothetical protein, len: 170 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935R0" FT /protein_id="CAD09643.1" FT /translation="MPRDCLIIPDCHRNSRWHGELKMTNKILILSASCINEFASDVPQS FT VFFSIDTSLAKRIRELAAYVKENDLYAAEFFFYDCHWSETLEEDIEVLMSQAAFIESDS FT SGQETMLRDVMPSCRTETTSIRVMKESFHLTAVPRHCGDDMMLNTPLIPLAELESNATV FT LITQQYS" FT CDS complement(14709..15515) FT /transl_table=11 FT /gene="HCM1.34c" FT /product="hypothetical protein" FT /note="HCM1.34c, hypothetical protein, len: 268 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935Q9" FT /protein_id="CAD09644.1" FT /translation="MANNYTQASFTILCSQEQAQMALDAIAYVTDTDVAEGEHLLSKPV FT SECSLTELLVLGIIQNHPECDPFEPTFGQSESPENNYELELKAEITGKGLAICHDESIN FT LDHAIAVTTAVLSVFNLPEMVTINAAFVCDRPRENEFGGATIVVTKDTHHYEEGFNFSR FT LMNEAHDAGVQYALVKVNQYNHEYTYTQCYLMSCKKSESAYDVARHRLASDESTPDNPG FT EDGVIILSEEDNTSMALHSVTELMPVVYESLSKLLPSLDELCPVTA" FT RBS complement(15523..15529) FT /note="possible RBS" FT CDS complement(15743..15934) FT /transl_table=11 FT /gene="HCM1.35c" FT /product="hypothetical protein" FT /note="HCM1.35c, hypothetical protein, len: 63 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935Q8" FT /protein_id="CAD09645.1" FT /translation="MMFDDEEEVMLVEADSCGEAEAAFQQHIDEGVAHLDQVLVISSAS FT LQSLLPDRLIASSLTHTV" FT CDS complement(16063..16395) FT /transl_table=11 FT /gene="HCM1.36c" FT /product="hypothetical protein" FT /note="HCM1.36c, hypothetical protein, len: 110 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5R5" FT /protein_id="CAD09646.1" FT /translation="MESEQLITKITQTLKRPDGSEVRIVVEQAFGSGLTPSLGVYVLRR FT PTTANNWQLCKTAPHKDWRTMSVDEYQKHGRSEMLRYVSIGEILRLSAAIGKPMSYVDT FT CPGLQG" FT CDS complement(16895..18076) FT /transl_table=11 FT /gene="HCM1.38c" FT /product="hypothetical protein" FT /note="HCM1.38c, hypothetical protein, len: 393 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935Q7" FT /protein_id="CAD09647.1" FT /translation="MKLFGISSRDSGMDAMFYIQASTKQQASFIFDFLATRLYAHCQLI FT EPLNETIIPSLSRTTLSLQPWSQNSQTRTSEMQMVTHGLTLSGAVMVEHSRQIVDFCDN FT LGLRLDAPTGKPGWTELINADCEQLNSPRLYPVLIQPGTEGQFQIYVPAPAVIDADTVI FT ASVIDECFSDVTSYCLAGTPFPMTEKPVIRMEAHLSDAHTRVFELTFISYNLALSATVY FT DKNLRQVLMLCEDFGVTLQGRAGASCHAYMRNEYRRLAHVGVYSRSGAENDVRAYSSDK FT EETLIRQLMTQATAGSALIPARHGKQFNGVLMNANPSSATTGFIYLSPEFPQGQFMMTA FT EVVKSSCTPRGISYIETVDGYRFIVTAYDTKAMHSLTEFLAVNEDYFTPYRWE" FT CDS complement(18085..18381) FT /transl_table=11 FT /gene="HCM1.39c" FT /product="hypothetical protein" FT /note="HCM1.39c, hypothetical protein, len: 98 aa; unknown FT function" FT /db_xref="InterPro:IPR007711" FT /db_xref="UniProtKB/TrEMBL:Q935Q6" FT /protein_id="CAD09648.1" FT /translation="MIHSFKDRRLEKFFRNGKSTAGIPAELINAISCRLETLNNVKNER FT ELLSGSLRYERLRMTANRYSSIRVNSKYRLFFEWNDGVHNVHLSAHDYKSLIH" FT RBS complement(18387..18391) FT /note="possible RBS" FT CDS complement(18445..18912) FT /transl_table=11 FT /gene="HCM1.40c" FT /product="hypothetical protein" FT /note="HCM1.40c, hypothetical protein, len: 155 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5R8" FT /protein_id="CAD09649.1" FT /translation="MDKYFDRSGMAIDNAKIKCIDSVKGTGEYIYRVTCNKCNGRGERN FT HFYKSRCIACNATGYSLVTTRTCYTLTALYRIYPEAARKISAAQAAERQRAVQSKTSAF FT NLWCQNHQELVDAITQQDGENSFLNSLKSTLSRKFPLSDKQLTVAARILGM" FT RBS complement(18920..18924) FT /note="possible RBS" FT repeat_region 18961..18997 FT /note="inverted repeat; 34/36 (94%) matches, 1 gaps" FT CDS 19211..19537 FT /transl_table=11 FT /gene="HCM1.41" FT /product="hypothetical protein" FT /note="HCM1.41, hypothetical protein, len: 108 aa; FT improbable CDS" FT /db_xref="UniProtKB/TrEMBL:Q9L5R9" FT /protein_id="CAD09650.1" FT /translation="MPVRHLNDALLPVAETVHMADMYNTHGLTQFRGVAQRRDAALIWK FT TQASTGASGSRHSQAETPEPVRLPAVSLVPVYKTRLIRRYRWRTPRRLEAFGNCLGQRT FT PAFR" FT RBS 19759..19763 FT /note="possible RBS" FT CDS 19772..20548 FT /transl_table=11 FT /gene="HCM1.42" FT /product="hypothetical protein" FT /note="HCM1.42, hypothetical protein, len: 258 aa; unknown FT function. Similar to HCM1.43, hypothetical protein (258 FT aa), fasta scores; E(): 1.7e-27, 32.8% identity in 262 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q9L5S0" FT /protein_id="CAD09651.1" FT /translation="MPKYLLPAELAEIVCGLLVQPALLNELKTPATHKAFMQDIGELVA FT KHCGGQIDGVIMPEVRDEDSQADYLTSPDETPYIVVSPGQDMHSLTDNVWRHHARDGWL FT DHIKGSVEESPDELPTHKECAVRRYTLQRLLLQEETSHANLPVQVVRMCEYSTDDVEQT FT DSSAEFNVTMALGGHAMLAVKDTDSRLVMALTLLIENGVPSVHVNAGDTDPSVLHIRAA FT HGGLVLSTDSLNHDFSISPSDQYTYGRPGLLLKAAY" FT repeat_region complement(20616..20651) FT /note="inverted repeat; 34/36 (94%) matches, 1 gaps" FT CDS 20698..21474 FT /transl_table=11 FT /gene="HCM1.43" FT /product="hypothetical protein" FT /note="HCM1.43, hypothetical protein, len: 258 aa; unknown FT function. Similar to HCM1.43, hypothetical protein (258 FT aa), fasta scores; E(): 2.7e-29, 32.8% identity in 262 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q935Q5" FT /protein_id="CAD09652.1" FT /translation="MAKLISTRELATIITALLVKPELLGELDSPEKHRALMEDLGRVVA FT EHCGGNVTEIALPETDGTAAEGALQNGQPVRYLETKESSPYLIVHPDASLPSVTQNVWM FT HADHDGWEEHFNGETDALTPEMSEQFRQQVYALLTPESHTTSSEMRLTLQDWQLGEAEI FT PEEDCQPYQVKVLAENKNVQCEVTNETGTTCFGLILEIDRGVPTLHIDTGSDSLLHIHA FT AHDGLVLTPDAPSHRFEDAPVDRFSYNSPSLLVPGV" FT RBS 21526..21530 FT /note="possible RBS" FT CDS 21539..21661 FT /transl_table=11 FT /gene="HCM1.43a" FT /product="hypothetical protein" FT /note="HCM1.43a, hypothetical protein, len: 40 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935Q4" FT /protein_id="CAD09653.1" FT /translation="MGDVATLPPKINDGVLRRWNARGKADKEALADYGVSVKEE" FT RBS 21650..21656 FT /note="possible RBS" FT CDS 21663..22004 FT /transl_table=11 FT /gene="HCM1.44" FT /product="hypothetical protein" FT /note="HCM1.44, hypothetical protein, len: 113 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5S2" FT /protein_id="CAD09654.1" FT /translation="MRELLGMAGAEHQASVMYQTFGHLDAKLGEKHKGHFVFINGQHGD FT LCVVHSEFSSFDEGPGYFSDRADFIWELVKNDGPCSKVGIYRFDGEYALPKRRNGRRFS FT GSVTCLQAF" FT CDS 22009..22368 FT /transl_table=11 FT /gene="HCM1.45" FT /product="hypothetical protein" FT /note="HCM1.45, hypothetical protein, len: 119 aa; unknown FT function. Contains PS00017 ATP/GTP-binding site motif A FT (P-loop)" FT /db_xref="UniProtKB/TrEMBL:Q935Q3" FT /protein_id="CAD09655.1" FT /translation="MLHERRQVFRTTGGGTVRVQPSPHNNSTEYIIMTNANANDGKTSP FT VLPTLEQVYALLKANYKPARFADRDGEIWGHEYSWNLARSSLQDLEKYGKSYVSKHSDR FT MGDGFSFGPDLVIIR" FT misc_feature 22114..22137 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 22596..23300 FT /transl_table=11 FT /gene="HCM1.46" FT /product="hypothetical protein" FT /note="HCM1.46, hypothetical protein, len: 234 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935Q2" FT /protein_id="CAD09656.1" FT /translation="MTMKNTVIPTVTENEMGEVITRHSAYGLVSVSRTSTTGQRLYASD FT LSHKEVVTMTFSESEQIERDGVIRHRLAEGRRRSPLLQVSLSPAQWATMITSFGMSDGV FT PCTINSLIRGDYERQPEIGYIESTRERYERQIREAAEREMAKLHEKLEVLRLLAVKGKA FT GKRELDEAYQSLLSVINNLPVNLAFTNQLIQESMVNIVSHGKAELEATAMGVAARLGMK FT EMSSLASLEEKK" FT CDS complement(23333..23752) FT /transl_table=11 FT /gene="HCM1.48c" FT /product="hypothetical protein" FT /note="HCM1.48c, hypothetical protein, len: 139 aa; unknown FT function. Contains g{8} repeat" FT /db_xref="UniProtKB/TrEMBL:Q935Q1" FT /protein_id="CAD09657.1" FT /translation="MSELAEKPLITRVAPLERIYYCASRAEGLKPDRHEIRMQSQFLLL FT GVIWLPPALAMAELERLLKGYDADHSRLLENVLETAHQQFLKFCEPQKREGGGVENHVE FT CPRQDDALQCLRFMSTRYALAVDLCAAYVCSRYGR" FT repeat_region complement(23460..23467) FT /note="(g)8" FT CDS complement(23840..26224) FT /transl_table=11 FT /gene="HCM1.49c" FT /product="putative periplasmic protein" FT /note="HCM1.49c, possible periplasmic protein, len: 794 aa; FT unknown function, contains probable N-terminal signal FT sequence and PS00017 ATP/GTP-binding site motif A (P-loop). FT Similar to HCM1.56c, possible periplasmic protein (818 aa), FT fasta scores; E(): 0, 35.4% identity in 831 aa overlap. FT Also similar in parts to HCM1.50, HCM1.51, HCM1.52 and FT HCM1.53 (in that order), suggesting that together they FT represent a pseudogene" FT /db_xref="UniProtKB/TrEMBL:Q7WZD9" FT /protein_id="CAD09658.1" FT /translation="MKFCRRPLIVAVYTALLFPLYSQAQLYNYSYTDTRGTKVNAEPTR FT EYLNPGSAITLNLISGLDRYERVTVTRSSDNVQMFQSVTGLVTVADRITAADGSEYYGK FT SMTLPVLGEGTFSLKSETLDNKSNVVATTSYSFSIDITPPVLPDPMQWIRAGFQYGSLD FT IFGDRTATQAISLSNVSDARSGLDKAEWFAIDSSGVRRTVNAQLNALTGVVQALAAVAA FT GSTVAPVSPAYYTVGFRVYDKAGNWTETSHRSGIDRTIPSYIQHQVRNAKTGVWEDYVP FT GMTIFENPVKFRYKRLKSDSTNFNGTDFGWVDQITNSDNTYFYTEATVSYPETYMYYEL FT HTKAGLNVNLQYKTLKFTPGNGVAEAPRYLSGQYHFRDANTWTSSDIVRFTGPDCVDLG FT RVNVEPRSYVQTATIVGIGSCNVSVGESSCQVSMNYCKTSGKGYVPYQIHIRGTGSYAN FT LGGLQSHFYTYWDMNAPVINSIVSSPLDKTVVMLVTDSDVTNDWTNYMWATNIFNLTLK FT DTSNKVSTLSPKNVTVLNYQLKQVTFDYSALPSGKYTATGAATDTYNNTAELTLSNTIL FT HDVTPPVVDISFEGKQADGALVKGLENLVITLADDMTKASLKSITLSGGPTSDKVSVGW FT YSQGTDKYGLNYPRIFPATDDADSYQLTAVAVDEAGNTTTKVSRFRYVPNNLIEFNTLK FT TLAVGMGLKTSDNQPLAYLRTNSIRKKDGSLITGAQTGTLTVRKDAAFAVSMNGVAVVP FT GDSKDITIDFGQGDGVLIPIFPATSGNVGESSFMIELPQIQ" FT misc_feature complement(25910..25933) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT RBS complement(26232..26236) FT /note="possible RBS" FT CDS 26475..27077 FT /transl_table=11 FT /gene="HCM1.50" FT /product="putative periplasmic protein" FT /note="HCM1.50, possible periplasmic protein, len: 200 aa; FT unknown function, contains probable N-terminal signal FT sequence. Similar to the N-termini of HCM1.49c and FT HCM1.56c. HCM1.51, HCM1.52 and HCM1.53 (in that order) are FT also similar to the corresponding regions of HCM1.49c and FT HCM1.56c, suggesting that together they represent a FT pseudogene" FT /db_xref="UniProtKB/TrEMBL:Q7WZD8" FT /protein_id="CAD09659.1" FT /translation="MKNQAIALAMAMLGVSVPASAQIYESIFTDTNGIEVHAPSTRLLL FT NPASPVTLTLIAGLDRYVNVKITSATGTQLLNTTTTRTSVSDRLKAGDGSEFYGKKVTL FT PVLGEGRSVVQVSILDLNQSVVATYSYNWLVDTTPLSGNALTGNAAYGSTAGSVWKMGL FT EATGQFDFTSTNVTDVNGIEKGMFYVYHSNGSLFSTT" FT misc_feature 26475..28076 FT /note="extent of possible pseudogene" FT CDS 27180..27476 FT /transl_table=11 FT /gene="HCM1.51" FT /product="hypothetical protein" FT /note="HCM1.51, hypothetical protein, len: 98 aa; unknown FT function. Similar to parts of HCM1.49c and HCM1.56c. FT HCM1.50, HCM1.52 and HCM1.53 (in that order) are also FT similar to the corresponding regions of HCM1.49c and FT HCM1.56c, suggesting that together they represent a FT pseudogene" FT /db_xref="UniProtKB/TrEMBL:Q9L5S9" FT /protein_id="CAD09660.1" FT /translation="MTTQETPEPFRCSSFDMITIWAVRDPQSSASVVPGVSGYPAYSAG FT MTVNENPIHLVYRVPKSNYRSYAEGGLLFYNLYSSPTEIATDSTYTYVEMILP" FT CDS 27481..27894 FT /transl_table=11 FT /gene="HCM1.52" FT /product="hypothetical protein" FT /note="HCM1.52, hypothetical protein, len: 137 aa; unknown FT function. Similar to parts of HCM1.49c and HCM1.56c. FT HCM1.50, HCM1.51 and HCM1.53 (in that order) are also FT similar to the corresponding regions of HCM1.49c and FT HCM1.56c, suggesting that together they represent a FT pseudogene" FT /db_xref="UniProtKB/TrEMBL:Q7WZD6" FT /protein_id="CAD09661.1" FT /translation="MVYGLENIRIALADNLTTPRITRLQITGGPTADNVELTWSPAGTN FT VYAPEYPRLFPSFEPSENYALSVTVSDSQSNSKTYTQKFSYLPNNLVQLHNLRTLSVSS FT ALKTSLNEPLAYLSTNVLRKSNGEIAKTSRVRR" FT CDS 27936..28076 FT /transl_table=11 FT /gene="HCM1.53" FT /product="hypothetical protein" FT /note="HCM1.53, hypothetical protein, len: 46 aa; unknown FT function. Similar to parts of HCM1.49c and HCM1.56c. FT HCM1.50, HCM1.51 and HCM1.52 (in that order) are also FT similar to the corresponding regions of HCM1.49c and FT HCM1.56c, suggesting that together they represent a FT pseudogene" FT /db_xref="UniProtKB/TrEMBL:Q7WZD5" FT /protein_id="CAD09662.1" FT /translation="MQAALGESVEVKIDMGLGDNLLVPIYPAENGKVGTSEFMIQIDEL FT K" FT repeat_region complement(28329..28345) FT /note="iteron associated with repA; 83% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region complement(28350..28366) FT /note="iteron associated with repA; 84% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region complement(28371..28387) FT /note="iteron associated with repA; 89% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region complement(28392..28408) FT /note="iteron associated with repA; 100% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region complement(28415..28431) FT /note="iteron associated with repA; 90% identity to FT consensus TACCCGGTATAGTGGAT" FT CDS 28468..29349 FT /transl_table=11 FT /gene="repA" FT /gene_synonym="HCM1.54" FT /product="replication initiation protein" FT /note="HCM1.54, repA, replication initiation protein, len: FT 293 aa; highly similar to many RepHI1B repA proteins e.g. FT TR:Q08088 (EMBL:X68824), repA, Escherichia coli replication FT initiation protein from plasmid pIP522 (293 aa), fasta FT scores; E(): 0, 100.0% identity in 293 aa overlap. Contains FT Pfam match to entry PF01651 RepA, RepA family. Similar to FT HCM1.64, repA2, replication initiation protein (291 aa), FT fasta scores; E(): 7.2e-34, 35.2% identity in 290 aa FT overlap" FT /db_xref="GOA:Q7AQZ8" FT /db_xref="InterPro:IPR000525" FT /db_xref="UniProtKB/TrEMBL:Q7AQZ8" FT /protein_id="CAD09663.1" FT /translation="MSSNNNKLSLVIEESLKDSGEVIQLFPTLKQTIQPKVLLRLGVFV FT PTLKSTDKGGRKSHHIDATEPLSRLSIVEGEGYSQIQIYGPRLDMDTDFKSWCGIVYAL FT SNRPLDSEGQLELNFPEFAKFCGFDTKRIDKQLKERFDASLTRIARTNISFIKKIPGTD FT DQITINMHLVESTYYDSSTGKIIIKPNSKLNTLYRVDGKTRLYLKTLQKLARKESAQAL FT YLYLAELPSTFYRIGFDRLRGRLQLSSHLGNQNATVKKALGQLKEIGFLEYSIDKENGD FT YVLNILKRNMKP" FT misc_feature 28582..29331 FT /note="Pfam match to entry PF01651 RepA, RepA family, score FT 603.30, E-value 1.5e-177" FT repeat_region 29394..29410 FT /note="iteron associated with repA; 96% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region 29435..29451 FT /note="iteron associated with repA; 91% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region complement(29452..29468) FT /note="iteron associated with repA; 91% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region 29556..29572 FT /note="iteron associated with repA; 94% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region 29591..29607 FT /note="iteron associated with repA; 100% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region 29662..29678 FT /note="iteron associated with repA; 100% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region 29729..29745 FT /note="iteron associated with repA; 100% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region 29796..29812 FT /note="iteron associated with repA; 87% identity to FT consensus TACCCGGTATAGTGGAT" FT repeat_region 29851..29867 FT /note="iteron associated with repA; 92% identity to FT consensus TACCCGGTATAGTGGAT" FT CDS complement(29935..30432) FT /transl_table=11 FT /gene="HCM1.55c" FT /product="putative periplasmic protein" FT /note="HCM1.55c, possible periplasmic protein, len: 165 aa; FT unknown function, contains a possible N-terminal signal FT sequence" FT /db_xref="UniProtKB/TrEMBL:Q935Q0" FT /protein_id="CAD09664.1" FT /translation="MMKSNAPLIILICLMIAFSAYVKSWSLLYTLLAASVSLTVMISLP FT FIVSPLQHSKFIALRILRLLVITLWTIGLVGVFFSVVERLVWVNADSYPAWLAKELDSP FT AITDGENFIKATESFEKICGKNKGYLSVVTKHNGIFMRCDDSLSFDSWWKGVYRLKTPE FT TR" FT CDS complement(30447..30650) FT /transl_table=11 FT /gene="HCM1.55ac" FT /product="hypothetical protein" FT /note="HCM1.55ac, hypothetical protein, len: 67 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935P9" FT /protein_id="CAD09665.1" FT /translation="MIHFAEREARERKAHASSGPIVTLSSVIEAFFGIRFTPVQNDGNF FT SKAADDYKRSLSKLVQNGAPKE" FT CDS complement(31101..33557) FT /transl_table=11 FT /gene="HCM1.56c" FT /product="putative periplasmic protein" FT /note="HCM1.56c, possible periplasmic protein, len: 818 aa; FT unknown function, contains a probable N-terminal signal FT sequence. Similar to HCM1.49c, possible periplasmic protein FT (749 aa), fasta scores; E(): 0, 35.4% identity in 831 aa FT overlap. Also similar in parts to HCM1.50, HCM1.51, HCM1.52 FT and HCM1.53 (in that order), suggesting that together they FT represent a pseudogene" FT /db_xref="UniProtKB/TrEMBL:Q7WZD4" FT /protein_id="CAD09666.1" FT /translation="MRKILTGCIIATAIASVYPAAAQIFSYSYTDTNQLAKTLKPATQS FT YLNPASTMTLNLISGLDRYERVSVTRDSDKKVMYSAVTGKISVADRIVAADGTEYYGKD FT LALPALGEGAFTVINDTLDLQQAVVSSSTYHFTIDTTAPKYTSIYPSQNAGYEMVLSGP FT VWGLGRGGSGQFSIFADGVDDANGIDKIRLVIKRGNGTVVSDNTLSYDTAAKRAFYPWI FT KDSVTQPGMPTSDLNEEFTFNFIITDKAGNTLNIPPQRFLFDDQIGEYTPFAVHDSRVS FT TSVVPGISSGYVPFVRGLSVLENPYRMVIRIPRTNWKPYRNGGITILNNYGGAKVISED FT TTYVYVEVKLPQGALDINYYRPVNTYQWSGGDLTQYASWLNWDPASVKSPAWGSPAIER FT QMSDGTWFNSVNWKYFKASDMPVNLTQIRFNVQARPYDQKITGGATCNIPAGSTSCTVA FT LTQAITNGTTGYLHSGYEVRSTTESTFFMPIWENVVWHTLGPSVTGYDYNDTTNILQVY FT INQPGDGSYFDTVKLSRVWLSDKSRNNADINVTGTLTGRNTATGNYTYEFNLKLIPEGS FT YNVQLNAQDSFNNTGSLDYKTVTVDNTPPSISISYETKPITSSVTVYGLENIRIQLADT FT LTKPSLTRMTLRGGPVSDAVELSWVNLGNNLYAPNYPKIFPSLNDGETYTLTVQAKDEM FT NNVKESAVEFSYLPNNLVRLENLKTISVSTALKTSDDTPLAVLYASQLRKKDGSIATGK FT QDAILTVRKDAAFGVTVNGVSAAPGESKNVQLDLGLGDSRSFPIFPSTSGVVGTSEFML FT NIEELK" FT RBS complement(33564..33567) FT /note="possible RBS" FT CDS complement(34003..34179) FT /transl_table=11 FT /gene="HCM1.56ac" FT /product="hypothetical protein" FT /note="HCM.56ac, hypothetical protein, len: 58 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5T5" FT /protein_id="CAD09667.1" FT /translation="MSKSSPVLPEDRDDIEFVMDDFQRSLGKSKPVREVQFLGESQQSE FT ESANSADSPWFES" FT RBS complement(34186..34190) FT /note="possible RBS" FT CDS complement(34194..35948) FT /transl_table=11 FT /gene="HCM1.57c" FT /product="hypothetical protein" FT /note="HCM1.57c, hypothetical protein, len: 584 aa; shares FT a region of similarity with TR:O37396 (EMBL:AF021249), FT M.CviQIII, Chlorella virus NY-2A DNA probable adenine FT methyltransferase (372 aa), fasta scores; E(): 0.15, 29.4% FT identity in 119 aa overlap. C-terminal half similar to FT TR:Q52611 (EMBL:U03474) Proteus vulgaris ORF associated FT with restriction endonuclease PvuRts1 I (290 aa), fasta FT scores; E(): 2.5e-19, 29.1% identity in 292 aa overlap. FT Highly similar to TR:P95799 (EMBL:U60283), traG1, Serratia FT marcescens hypothetical restriction methylase from plasmid FT R478 (563 aa), fasta scores; E(): 0, 70.8% identity in 558 FT aa overlap. Contains PS00092 N-6 Adenine-specific DNA FT methylases signature" FT /db_xref="GOA:Q935P8" FT /db_xref="HSSP:2ADM" FT /db_xref="InterPro:IPR002052" FT /db_xref="InterPro:IPR002296" FT /db_xref="UniProtKB/TrEMBL:Q935P8" FT /protein_id="CAD09668.1" FT /translation="MSANLLAFCSRLLSWYQINPSKRTGAMSAVESDSLPMGAPGSSLV FT AYMPHTGLLINDDNFLPEMREELDVINRQVESYNDELSLLRSMSAQFLKCGNQKLYSYL FT SGYNHLISEADASYAENALRSEYWKRVMALTDVLSVMSDEKKKEWDKQFTADRYHLPPQ FT EIPDFTLDAVVTTVVALLNDRHQFIKDRVYAVFQSLSRQHKTNKAFGFSTRMITSGVCE FT GVKDKWVKLKVEFKESGLMPLSELRVICSYFRGETVKPVYDTKKMVENMVGHVGFRNWI FT SLDGNSIRFRVYKNGSMHIDVHPDIAERLNNILAAIVPLALPAERVAHTKATLQEFPAL FT KRCIDFHSRMQLAELDFTQNEKEWSSWTSLGYAGENADKTRQVNADVLRFLGARVTSYH FT VTFDYDPTEVMRFIGHMGAMPDIKSHQFYPSSARLSEYVASIIAAGEGERLLEPNIGHG FT DLLQCFPKSVNVTGIELDTLNCLVSRAKGYETTEADFLAWSAANQIQKFDCVVMNPPFA FT DNRAKLHLLAAASHLVPGGRLAAVLPLSLQGIDNLLGEGFRTEWMDTFDNEFDNTAVSV FT RVLYAERF" FT misc_feature complement(34401..34421) FT /note="PS00092 N-6 Adenine-specific DNA methylases FT signature" FT CDS complement(36134..37291) FT /transl_table=11 FT /gene="HCM1.58c" FT /product="putative DNA-binding protein" FT /note="HCM1.58c, possible DNA-binding protein, len: 385 aa; FT contains a region of weak similarity to putative chromosome FT partitioning proteins e.g. TR:O84694 (EMBL:AE001339), parB, FT Chlamydia trachomatis chromosome partitioning protein (281 FT aa), fasta scores; E(): 0.0018, 26.7% identity in 135 aa FT overlap. Contains a possible helix-turn-helix motif at aa FT 184-205 (Score 1105, +2.95 SD). Similar to HCM1.286c, FT possible DNA-binding protein (401 aa), fasta scores; E(): FT 1.1e-19, 31.9% identity in 298 aa overlap and HCM1.63c, FT hypothetical protein (358 aa), fasta scores; E(): 3e-16, FT 28.6% identity in 290 aa overlap" FT /db_xref="GOA:Q9L5T7" FT /db_xref="UniProtKB/TrEMBL:Q9L5T7" FT /protein_id="CAD09669.1" FT /translation="MSDLMTDSQQQTNSRVFKSPLVSFSTVTGSGRFVSGMKQFRDANP FT DLCNEVTEQKAWAISPTVVQITEGFNSREMGMGEAYYQLPEVADHLNNIKNAYIRGDYV FT DPIRVLIKDGIPYVRQGHCRLKAALMAVAEGHSNLTILCIEMKADEISCELTTIDGNRG FT LALSPVALGESYRRLQALGGWSLDRIAEREGKSNTTIAALIRLTGCCVYLKKLIHADAI FT SYVAVLSLIDEFGETEAVARIEKMIADLEKADSSGIQIKKTPRGQIRVVPSDFKPARVP FT PVLATKAVEGVKLITTSLLQKLGDIELPEVTDSSEDEEITFTLNRSMLEMLKNLQSEIT FT ESENKQLRRAENRQARLKGEKVTYKTKKNDKNGGEPQSETPPAQA" FT RBS complement(37297..37300) FT /note="possible RBS" FT RBS 37639..37642 FT /note="possible RBS" FT CDS 37651..38475 FT /transl_table=11 FT /gene="HCM1.59" FT /product="putative DNA modification methylase" FT /note="HCM1.59, possible DNA modification methylase, len: FT 274 aa; similar to many modification methylases e.g. FT SW:ML21_LACLC (EMBL:U16027), LlaIIA, Lactococcus lactis FT modification methylase (284 aa), fasta scores; E(): FT 1.1e-26, 36.5% identity in 271 aa overlap. Contains PS00092 FT N-6 Adenine-specific DNA methylases signature" FT /db_xref="GOA:Q935P7" FT /db_xref="HSSP:2DPM" FT /db_xref="InterPro:IPR002052" FT /db_xref="InterPro:IPR002294" FT /db_xref="InterPro:IPR012326" FT /db_xref="InterPro:IPR012327" FT /db_xref="UniProtKB/TrEMBL:Q935P7" FT /protein_id="CAD09670.1" FT /translation="MRKHTPIIKWAGGKTKLMPFLSKHFPHDKSRRWVEPFIGGGAVFL FT NMFATEALLADSNPDLINLYRNIQRNKPAFIREVQLLAERHFEEEDYYVLRNTFNSTSF FT DDAPLQRAAIFYAMNRLGYNGLCRYNLKRKFSVPWGKRYQFSLDIQKVDYLSFRLSSVE FT LKTADFGQTLEFAGGGDQIYCDPPYDKISKTSFVSYDGIPFDKSAHVKLADMLVDANRK FT GASVAISNSMTPFTLELYEERGFDIHTHNAYRSVGSQSKSRKKEIEILAVLR" FT misc_feature 38194..38214 FT /note="PS00092 N-6 Adenine-specific DNA methylases FT signature" FT CDS complement(38490..39311) FT /transl_table=11 FT /gene="HCM1.60c" FT /product="hypothetical protein" FT /note="HCM.60c, hypothetical protein, len: 273 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5T9" FT /protein_id="CAD09671.1" FT /translation="MQNDLGLGFIRKSARTSAKIISRKVTFPLDDLDNAKLTLTGLQCH FT PSCRFPFYQLSMLIHNQLAEHGVISADENAPFTVSISIHEWLSRARVAFIDYHGLRNSD FT KTVMITRAHLEELLTYLSTTLAVYVPYSKKRLNFSFLTSFTLVKTSQSYTLTFPGVLRP FT FLMLLGGLIQEFMTEKLLKRRNAQFVIFDYLRKSRRHSHKITDIVNDLQLHTVNVRIMN FT VLTQLADQGFISFICEGKRGERSIEELQFIPYASRDHSEVLSFEEWISPID" FT RBS complement(39318..39321) FT /note="possible RBS" FT CDS complement(39594..40301) FT /transl_table=11 FT /gene="HCM1.61c" FT /product="hypothetical protein" FT /note="HCM.61c, hypothetical protein, len: 235 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5U0" FT /protein_id="CAD09672.1" FT /translation="MKHSLFFTQDGYLLPSSVKPIYGKDGHYYAVITRECFECGGTGKI FT ANAVCVTCNGSKTSPATEEKLVLKECIEFLETIPELRCNPDLEAWKRRHSEQLALLQAD FT NSKFAASIAQQLNNNLFLTVRQLESFYSTYQPVSEAFSENAGFPIEHSFNIGDVVSFDI FT IFTEVRAAFSKGSHSYFFTFTGKKQNDGFALTGNVQDHVLLGHSYHLSGKVRKIHYFDS FT VPYALLTVFKLTA" FT CDS complement(40298..40498) FT /transl_table=11 FT /gene="HCM1.62c" FT /product="hypothetical protein" FT /note="HCM.62c, hypothetical protein, len: 66 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935P6" FT /protein_id="CAD09673.1" FT /translation="MDKIAQFTVINTYNDLLITKGTLDRNIEEIKAGKRFDHFEEGHDQ FT YVQKVTDALQLVEARLENLKK" FT RBS complement(40313..40316) FT /note="possible RBS" FT RBS complement(40505..40510) FT /note="possible RBS" FT CDS complement(40516..41592) FT /transl_table=11 FT /gene="HCM1.63c" FT /product="hypothetical protein" FT /note="HCM.63c, hypothetical protein, len: 358 aa; unknown FT function. Similar to HCM1.58c, possible DNA-binding protein FT (385 aa), fasta scores; E(): 7.5e-20, 28.6% identity in 290 FT aa overlap and HCM1.286c, possible DNA-binding protein (401 FT aa), fasta scores; E(): 1.6e-14, 32.8% identity in 189 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q9L5U2" FT /protein_id="CAD09674.1" FT /translation="MNHCDYQIIEISPKALFIESGFNPREAVIGELCYEQEPVKSTIVS FT IKQAYKEGRRVDLIKVVKKDSNYVVRQGHCRYRALSLALAEGADIQLISVVVMNYKNKS FT EEYLENLDGNRNNGLNPVALAYALAEALKLGSTVESLAMRYQRSSTAIRNQLKILDMPL FT ELQRLISLNLIKKTLAIEIMLKYSNDHAKVLAHLESCSLLVPSTEPEPVLSKTSSVQTS FT SNDEKLDNPETLPVHVIPKEVKTKSITRSSLGIKRLSHKKTERLKTEFIGLIDTVRPAL FT NDSNKLTELIFDGQHSNLFTNISSTSITKTTESVKITLDEAKLQLLLSLLNDENTAIII FT PKSKVTELHEIRDLLTSE" FT RBS complement(41598..41603) FT /note="possible RBS" FT repeat_region 41991..42009 FT /note="iteron associated with repA2; 93% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 42012..42030 FT /note="iteron associated with repA2; 88% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 42033..42051 FT /note="iteron associated with repA2; 83% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 42056..42074 FT /note="iteron associated with repA2; 92% identity to FT consensus AAAAGCATTTGCATGAATG" FT CDS 42127..43002 FT /transl_table=11 FT /gene="repA2" FT /gene_synonym="HCM1.64" FT /product="replication initiation protein" FT /note="HCM1.64, repA2, replication initiation protein, len: FT 291 aa; identical to TR:Q07464 (EMBL:M95772), repA, FT Salmonella typhi replication protein from plasmid R27 (291 FT aa), fasta scores; E(): 0, 100.0% identity in 291 aa FT overlap. Contains Pfam match to entry PF01651 RepA, RepA FT family. Contains probable helix-turn-helix motif at aa FT 113-134 (Score 1269, +3.51 SD). Similar to HCM1.54, repA, FT replication initiation protein (293 aa), fasta scores; E(): FT 0, 35.2% identity in 290 aa overlap" FT /db_xref="GOA:Q7BRX0" FT /db_xref="InterPro:IPR000525" FT /db_xref="UniProtKB/TrEMBL:Q7BRX0" FT /protein_id="CAD09675.1" FT /translation="MSDNNEVTHPFDVTNTETGKTYQLSPNSSKSVQPIALLRLSVFTP FT VGTKEKRYRNFEVDASDELSSMELARSEGYDDIRITGLKLSMSTDFKCWLGCIMAFSKY FT GFASDKITLSFNEFAKMCGISSTNINKRTRSRFQEALANLASVVISFRDSKTERFTVTH FT LVQKAVIDPKKDTVELVGDPSMWELYRYDHKTLLSLQVLSVLAKKEAAQSLYIYFEAMP FT AGTLFVSMKRLRERLLLTTPVRTQNQIIRKAMLELKSIGYLEYQEVKKGRDIQFQIFKR FT SPKLALAKHS" FT misc_feature 42127..77106 FT /note="98.1% identical to Salmonella typhi plasmid R27 tra2 FT region (EMBL:AF105019) bases 2880..38245" FT misc_feature 42238..42966 FT /note="Pfam match to entry PF01651 RepA, RepA family, score FT 558.90, E-value 3.4e-164" FT repeat_region complement(43057..43075) FT /note="iteron associated with repA2; 98% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region complement(43151..43169) FT /note="iteron associated with repA2; 88% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region complement(43235..43253) FT /note="iteron associated with repA2; 89% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43476..43494 FT /note="iteron associated with repA2; 89% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43495..43515 FT /note="repeat associated with repA2; 91% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT repeat_region 43520..43538 FT /note="iteron associated with repA2; 90% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43538..43558 FT /note="repeat associated with repA2; 91% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT repeat_region 43563..43581 FT /note="iteron associated with repA2; 94% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43581..43601 FT /note="repeat associated with repA2; 91% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT repeat_region 43605..43623 FT /note="iteron associated with repA2; 99% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43624..43644 FT /note="repeat associated with repA2; 85% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT repeat_region 43667..43687 FT /note="repeat associated with repA2; 93% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT repeat_region 43692..43710 FT /note="iteron associated with repA2; 92% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43711..43731 FT /note="repeat associated with repA2; 88% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT repeat_region 43736..43754 FT /note="iteron associated with repA2; 94% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43755..43775 FT /note="repeat associated with repA2; 92% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT repeat_region 43780..43798 FT /note="iteron associated with repA2; 95% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43799..43819 FT /note="repeat associated with repA2; 83% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT repeat_region 43824..43842 FT /note="iteron associated with repA2; 100% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43867..43885 FT /note="iteron associated with repA2; 94% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43910..43928 FT /note="iteron associated with repA2; 89% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43953..43971 FT /note="iteron associated with repA2; 90% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 43997..44015 FT /note="iteron associated with repA2; 99% identity to FT consensus AAAAGCATTTGCATGAATG" FT repeat_region 44055..44075 FT /note="repeat associated with repA2; 81% identity to FT consensus GGGCGCTGAAAGGTGCCTTTG" FT RBS 44347..44350 FT /note="possible RBS" FT CDS 44356..44709 FT /transl_table=11 FT /gene="trhA" FT /gene_synonym="HCM1.67" FT /product="putative pilin precursor" FT /note="HCM1.67, trhA, probable pilin precursor, len: 117 FT aa; highly similar to TR:AAD54053 (EMBL:AF105019), trhA, FT Salmonella typhi putative pilin from plasmid R27 (117 aa), FT fasta scores; E(): 0, 99.1% identity in 117 aa overlap. R27 FT trhA shown to be involved in plasmid transfer by mini-Tn10 FT knockout. Contains a probable signal sequence similar to FT that of SW:P04737 (EMBL:K01147), traA, Escherichia coli FT F-plasmid pilus. Very weak similarity to and conservation FT of gene order with Escherichia coli F-plasmid traALE genes" FT /db_xref="UniProtKB/TrEMBL:Q935P5" FT /protein_id="CAD09676.1" FT /translation="MELTLNTNVERGKTNAFAFLKSKHAKVPLFILLVLANCSFAYAGS FT DDGAFGDIWAYMSEALTGAPGKIIACGMLFSVAYFGVVKPNLGLALVSALMMLVMANGE FT KIISSFLDAGIPL" FT CDS 44728..45078 FT /transl_table=11 FT /gene="trhL" FT /gene_synonym="HCM1.69" FT /product="putative plasmid transfer protein" FT /note="HCM1.69, trhL, probable plasmid transfer protein, FT len: 116 aa; identical to TR:AAD54052 (EMBL:AF105019), FT trhL, Salmonella typhi putative pilus synthesis and FT assembly protein from plasmid R27 (116 aa), fasta scores; FT E(): 0, 100.0% identity in 116 aa overlap. R27 trhL shown FT to be involved in plasmid transfer by mini-Tn10 knockout. FT Contains hydrophobic, possible membrane-spanning regions. FT Very weak similarity to and conservation of gene order with FT Escherichia coli F-plasmid traALE genes" FT /db_xref="UniProtKB/TrEMBL:Q9RGT2" FT /protein_id="CAD09677.1" FT /translation="MRGIFPLSGVFMTSQYEIPPHTYRFPYRINMPLLILFWDAKQLGI FT TFVTIASGNIFDFFITSVVVAVVFWFAYKKAAEEGIRGKLKHKLWWYGFFPGKSVFSSR FT YFTDPFIRNLYS" FT CDS 45078..45875 FT /transl_table=11 FT /gene="HCM1.70" FT /gene_synonym="trhE" FT /product="putative pilus assembly protein" FT /note="HCM1.70, trhE, probable pilus assembly protein, len: FT 265 aa; identical to TR:AAD54051 (EMBL:AF105019), trhE, FT Salmonella typhi putative pilus assembly protein from FT plasmid R27 (265 aa), fasta scores; E(): 0, 100.0% identity FT in 265 aa overlap. R27 trhE shown to be involved in plasmid FT transfer by mini-Tn10 knockout. Very weak similarity to and FT conservation of gene order with Escherichia coli F-plasmid FT traALE genes, however traE (and homologues) have a strong FT predicted hydrophobic region near the N-terminus absent FT from this predicted CDS" FT /db_xref="UniProtKB/TrEMBL:Q9RGT3" FT /protein_id="CAD09678.1" FT /translation="MELRMKLLSRLKIPFIKNSSNGDFDNKDETSQKGGEEVKGSFLDS FT KARFSKEIEGSEIGITYSALIKRDEKLLRVNTVAMIIIGVLVVKNQFLTDPVTIVLPPN FT MTEEVKVVGNKASESYKTQWALFFSTLIGNINPTNIGFVTTTILDALSPDLQAKTRESL FT QQQTNIMQARGVEQSFKPIDMYYDTKNDMVYVWGTKSTRLINVPDKTESSKWTFEWVLG FT MKNGRPRIAYVNQYSGTPNIKKITINGKEQLATLDNPPPSIGN" FT CDS 45878..47110 FT /transl_table=11 FT /gene="HCM1.71" FT /product="putative periplasmic protein" FT /note="HCM1.71, possible periplasmic protein, len: 410 aa; FT identical to TR:AAD54050 (EMBL:AF105019) Salmonella typhi FT hypothetical protein from plasmid R27 (410 aa), fasta FT scores; E(): 0, 100.0% identity in 410 aa overlap. Contains FT a probable N-terminal signal sequence" FT /db_xref="UniProtKB/TrEMBL:Q9RGT4" FT /protein_id="CAD09679.1" FT /translation="MTSKKVFHCTAITAVILLATSNVVFAEDYQLPATVNNPVVMPVGA FT DEFQNGVKNAIIKDTGTTTETVQATKPTTALPSLSPASSASPAVNEITGALSNNPTLAG FT YQQQVKSGNFDSYGRPAGKEPQQNAQSTGSPSKADELYVEARNRYKEVQRVNVPPGGNI FT VLPVSRGLQNRISTSFKNASVSTSTPADEASIFVNGGDVFISTNTDKPIGIMLSEDSVP FT ESTYNLTLVPLDVPGAMISVTTSLSPTMQAKRETSLDKQNYDEMLARSQSEELTPSDPR FT QDDHKQRIIDLLTPVALGEVPSGFSLQEDRLSRIPSSEQSPCNFNMYAKLGQRLVGSRE FT LIDVVLVKNDKPYGQVVADQQCITEGVVASALFDKAFLQPGEETELYIVRDKLFKERQT FT RVTTRPSLIKR" FT CDS 47112..47552 FT /transl_table=11 FT /gene="HCM1.72" FT /product="putative membrane protein" FT /note="HCM1.72, possible membrane protein, len: 146 aa; FT identical to TR:AAD54049 (EMBL:AF105019) Salmonella typhi FT hypothetical protein from plasmid R27 (146 aa), fasta FT scores; E(): 0, 100.0% identity in 146 aa overlap. Contains FT hydrophobic, possible membrane-spanning region near the FT N-terminus" FT /db_xref="UniProtKB/TrEMBL:Q9RGT5" FT /protein_id="CAD09680.1" FT /translation="MRKATFLTVISFGLVVFLGTSYYYQTKYIPKGTVNIFPDVHRQGE FT IVDDAFEKSTIVISDPTLADKFVGSSTESVGRHEVNVIKELGTQNNGSKFIHDESDKSG FT LTVGDKWPRAGEPYIVPQMTEYERNLKVKRFQQPKNGVNNGH" FT RBS 47532..47535 FT /note="possible RBS" FT CDS 47542..48900 FT /transl_table=11 FT /gene="trhB" FT /gene_synonym="HCM1.73" FT /product="putative plasmid transfer protein" FT /note="HCM1.73, trhB, probable plasmid transfer protein, FT len: 452 aa; identical to TR:AAD54048 (EMBL:AF105019), FT trhB, Salmonella typhi putative pilus assembly protein from FT plasmid R27 (456 aa), fasta scores; E(): 0, 100.0% identity FT in 452 aa overlap. R27 trhB shown to be involved in plasmid FT transfer by mini-Tn10 knockout. Also similar to transfer FT genes from other plasmids e.g. TR:Q9Z4H6 (EMBL:AF030442), FT htdB, Serratia marcesans pilus assembly protein homolog FT from plasmid R478 (388 aa), fasta scores; E(): 0, 82.2% FT identity in 388 aa overlap. Contains a possible N-terminal FT signal sequence" FT /db_xref="InterPro:IPR010501" FT /db_xref="UniProtKB/TrEMBL:Q9L5U6" FT /protein_id="CAD09681.1" FT /translation="MDIKKAWENKTVRISVIGAALMVLIVVISQSIFTTPVKKEKKTQK FT KDMQTGFLIDDSQMNKLSNEESQKTYNEMVRQNRIDQNAAKADRDKAEKAQQENKAQIA FT SLASQVQQLTTQLTEMQTSRNGNRNLDAGGPRNNVNEQAPAKPYQLNPNAAVNGVSSGY FT APISPTRNSPMRTITQSSIKTNGTDGVIQVMPISENRIREGREVVAGSEKAPTRTIRGD FT GTAPVDSKARHAARKDEMFLPATSIITGVLITGLEAPTSLSSKAEPMPVTMRIKKDIIM FT PNNYTMDLRDCNLLGSAVGDLASQRAYIRATSISCVNSKGKAFDVIVEAYAVSENDGKN FT GIRGNLISRNGNAIAGSAFAGGLSALAGSLSPSKVSSLNIDPNSTAQYQSPNIGALGAL FT AGAGAAQGGLNRLVDYYTSIAEQQWPIVEISPGRPITFVVQKGATIPTNLTSR" FT CDS 48909..49421 FT /transl_table=11 FT /gene="HCM1.74" FT /product="hypothetical protein" FT /note="HCM1.74, hypothetical protein, len: 170 aa; FT identical to TR:AAD54047 (EMBL:AF105019) Salmonella typhi FT hypothetical protein from plasmid R27 (170 aa), fasta FT scores; E(): 0, 100.0% identity in 170 aa overlap" FT /db_xref="InterPro:IPR000595" FT /db_xref="UniProtKB/TrEMBL:Q9RGT7" FT /protein_id="CAD09682.1" FT /translation="MENNNDNESPKKSESADSLNIDAAKPVGGIRTTKKVTLEIDIEKT FT LKYLMVAGLAVLIVIYGYKGGRFVYDNFKAMSQPAYQIAVLDMQTLRKVFNKQNPVLDS FT QQSKTNFENYFKALMKVYRERGYLVIDASLAVTIPENVEIVSYIDLGGSFGEVQSLPGE FT PKESEIR" FT CDS 49422..50279 FT /transl_table=11 FT /gene="HCM1.75" FT /product="putative plasmid transfer protein" FT /note="HCM1.75, possible plasmid transfer protein, len: 285 FT aa; identical to TR:AAD54046 (EMBL:AF105019) Salmonella FT typhi hypothetical protein from plasmid R27 (250 aa), fasta FT scores; E(): 0, 100.0% identity in 250 aa overlap. FT N-terminal half is highly similar to TR:Q9Z4H5 FT (EMBL:AF030442), htdT, Serratia marcesans putative transfer FT associated protein from plasmid R478 (157 aa), fasta FT scores; E(): 0, 69.0% identity in 142 aa overlap, shown by FT Tn7 insertion to be involved in transfer" FT /db_xref="InterPro:IPR012336" FT /db_xref="UniProtKB/TrEMBL:Q935P4" FT /protein_id="CAD09683.1" FT /translation="MKKLLLSLLISITSACPPLTLAVENVLNNRDAAALMEKAKEGGVS FT TKPLDGVLAKMKSYKPKDAIYIPTGGLYLFQDERSQLMAVTTDGRYTITGGSVMDILQR FT KSVLSVEDIRKSFFINLDDAPFPLETVASIPLGNPKLKRQAAIFITLDCDGCQDLIKKF FT YDEREKYRVDIVLIPSPGEPKQELRQLWCSKEKGKVNDLDILRWLMGNKADIEKRLLTK FT EEAEACPAEPLVASLMLAGIYKLQGVPSVVRQDGLAGNGIPKDFDYWLKQSVEPLLKNP FT FDTN" FT CDS 50289..51239 FT /transl_table=11 FT /gene="trhV" FT /gene_synonym="HCM1.76" FT /product="putative plasmid transfer protein" FT /note="HCM1.76, trhV, probable plasmid transfer protein, FT len: 316 aa; identical to TR:AAD54045 (EMBL:AF105019), FT trhV, Salmonella typhi probable plasmid transfer protein FT from plasmid R27 (316 aa), fasta scores; E(): 0, 100.0% FT identity in 316 aa overlap. R27 trhV shown to be involved FT in plasmid transfer by mini-Tn10 knockout. Highly similar FT to TR:Q9Z4H4 (EMBL:AF030442), htdD, Serratia marcesans FT putative transfer associated protein from plasmid R478 (324 FT aa), fasta scores; E(): 0, 79.2% identity in 313 aa FT overlap, shown by Tn7 insertion to be involved in transfer. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)" FT /db_xref="InterPro:IPR014118" FT /db_xref="UniProtKB/TrEMBL:Q9RGT9" FT /protein_id="CAD09684.1" FT /translation="MNIKKVIFSALVVGSSSYLAGCTIGSAESECPGIEKGVICKGPRE FT VMELTNNRDDLSGLGEEEANSGKGKSAVNDSQYPAQLTPPGAVQYPKSSVLVNKPVTYT FT TTEVKPVGQLPVMYDQTLKMGAPTSTIGPRPISGNPVNSNVRMTTSYNSNGSSVNPFLH FT PSAEVVKKTTQVVTPAPAPRYVAPNSDINASKDLYSINNGQPVNPTLSSGQVQQYRTQG FT YKQAVVAPEPLAVLQQGRVMRITFAPYTDDNDALNLPGFVYVNVKPQTWIAGKNSTSNP FT ARIVPLEVQDAARENMQQQQRATKAVSSNGIVRQL" FT misc_feature 50478..50501 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT RBS 51238..51241 FT /note="possible RBS" FT CDS 51248..53929 FT /transl_table=11 FT /gene="trhC" FT /gene_synonym="HCM1.77" FT /product="plasmid transfer protein" FT /note="HCM1.77, trhC, plasmid transfer protein, len: 893 FT aa; highly similar to TR:AAD54044 (EMBL:AF105019), trhC, FT Salmonella typhi plasmid transfer protein from plasmid R27 FT (887 aa), fasta scores; E(): 0, 99.2% identity in 893 aa FT overlap. Also similar to SW:TRAC_ECOLI (EMBL:M30936), traC, FT Escherichia coli transfer protein from the F plasmid (875 FT aa), fasta scores; E(): 9.1e-15, 22.8% identity in 893 aa FT overlap and to other traC homologues. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)" FT /db_xref="UniProtKB/TrEMBL:Q935P3" FT /protein_id="CAD09685.1" FT /translation="MRSANVYNKELSRHQLGGFIPVYDQIPGTHYFLLDGNRLGFMFIC FT SPSPGVFDNQQDVLTELFKMDFPTDTICQTSLTALPDLILHLSAWSAVRGGRMEGHDKL FT KGDLLTAYQLDYYDRSLNEPLKPDHDKLMLRDFQVWISFSIPLKSALPSEIEKSRIDAL FT YSDLISKLNTVGLFPHKVGAENWLYCMDKLLHPGKTSRWSEGHVEASTMRRLNEQINVP FT GRKYTVTENHFSSTTQSNDISEHRYFKQLSVVKFPEFVNFGCMYELVVNWLNGRKTIFS FT PFMITQTVHFADPLKLSRENVRYKAITNKQASIPTVLTFCPRLKDMDNDYMTITRELED FT GARLLHSYLTFTVMGNSAVDVQSAADQLKSFYLESRVNVADDSYIVFPSFVSSLPMCND FT PKTILELDRFEVVSNTGAAHMTPIFGPWKGNTDRPVLNLVSREGQLLGLDIFKTSASYN FT MVVGATSGAGKSFWVAYIINNYLGAGPRSNNLIHYRDTFEGFKNNSYDAFDPDGAQIFV FT VDVGRSYQGISEQYTNSQFIDFGKKPDFTLNPFAFLTDVTVGERVFDEAPVFNDDSNNH FT DDDKDKVAQTIMVLNQLKIMASEKGNIDDFQQSVMLQLISEEYNESRKVGRTGSITGFA FT RRCSNHEDKRIKDIGDQLGQWCEGGIYGNRFTENLPPINFDSRFIVLELEELKGTPHLQ FT TVVLMSIIQAAQHAMFIKKDGRRRLFILDEAWEYIRPDNASGSSNHSNQFFSSFLEAAW FT RRFRKTNCAGICITQSFEDYFTSSVGRALTANSPWKIIMKQEKESIEAMKVNNYFSTTD FT AEYERMKNIRTVKRAFSEMLVRFENFQEICRLYVDRKMELCFTTDSTDRGKLWEIQSRL FT DCSYGEAIEILYEQEVASKSAA" FT misc_feature 52634..52657 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT repeat_region 54578..54631 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 54632..54685 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 54686..54739 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 54740..54793 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 54794..54847 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 54848..54901 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 54902..54954 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 55753..55806 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 55807..55860 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 55863..55911 FT /note="54 bp direct repeat (bases 5 - 54)" FT repeat_region 55912..55965 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 55966..56018 FT /note="54 bp direct repeat (bases 2 - 54)" FT repeat_region 56019..56072 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 56073..56126 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 56127..56180 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 56183..56231 FT /note="54 bp direct repeat (bases 5 - 54)" FT repeat_region 56232..56283 FT /note="54 bp direct repeat (bases 3 - 54)" FT repeat_region 56284..56335 FT /note="54 bp direct repeat (bases 3 - 54)" FT repeat_region 56336..56387 FT /note="54 bp direct repeat (bases 3 - 54)" FT repeat_region 56388..56441 FT /note="54 bp direct repeat (bases 1 - 54)" FT repeat_region 56442..56495 FT /note="54 bp direct repeat (bases 1 - 54)" FT CDS 56742..57995 FT /transl_table=11 FT /gene="HCM1.86" FT /product="putative plasmid partition protein" FT /note="HCM1.86, possible plasmid partition protein, len: FT 417 aa; identical to TR:AAD54041 (EMBL:AF105019), parB, FT Salmonella typhi putative partition protein from plasmid FT R27 (417 aa), fasta scores; E(): 0, 100.0% identity in 417 FT aa overlap. Shows weak similarity to TR:Q44030 FT (EMBL:X90708), parA28, Alcaligenes eutrophus protein FT involved in plasmid partitioning and stability (306 aa), FT fasta scores; E(): 8.6e-07, 27.3% identity in 278 aa FT overlap. Contains a probable helix-turn-helix motif at aa FT 50-71 (Score 1015, +2.64 SD)" FT /db_xref="UniProtKB/TrEMBL:Q9RGU3" FT /protein_id="CAD09686.1" FT /translation="MNLIDKIALVGQRMKSEQISLKESLLVSSRVSVSDDSVDGVDRLI FT YNHCLNKKNLSDFFGKSRVTFNKILADLEEKELVGAPIYQNKNHLYTRWDVQKIMDALN FT YPRYSDYYCSRTIVTQNHKGGTGKSTTSGVLAVAAALDLHLNARILLIEWDPQGSIGSG FT MIQSVAEDDVFLTAIDAILGVYEEDSDYRKYLDLGYSEEQIIEGMPFSTHLPNLDVITA FT FPTDARFKDKYWQCSREERTELLLRFKEVILPVLKSKYDLIIIDTPPEDSPITWAADEA FT ADGILVAVSPREYDYASTTDFMLTISERFKQSPSKGENLSWFKVLAVNVDDKSPYEKIV FT LDKLVRTVQELFMSANIKNSEAFKAAASRGRTVLDIKKSEELCSPKQLDVAEESVMAVY FT QQFINEIKSFSVKQGGNV" FT CDS 57992..58999 FT /transl_table=11 FT /gene="HCM1.87" FT /product="putative plasmid partition protein" FT /note="HCM1.87, possible plasmid partition protein, len: FT 335 aa; identical to TR:AAD54040 (EMBL:AF105019), repA, FT Salmonella typhi putative replication protein from plasmid FT R27 (335 aa), fasta scores; E(): 0, 100.0% identity in 335 FT aa overlap. Similar to plasmid partition proteins (some FT putative) e.g. SW:PARB_ECOLI (EMBL:X02954), parB, FT Escherichia coli plasmid partition protein (343 aa), fasta FT scores; E(): 1.1e-15, 27.9% identity in 315 aa overlap. FT Contains a probable helix-turn-helix motif at aa 174-195 FT (Score 1336, +3.74 SD)" FT /db_xref="GOA:Q9RGU4" FT /db_xref="InterPro:IPR003115" FT /db_xref="InterPro:IPR014884" FT /db_xref="UniProtKB/TrEMBL:Q9RGU4" FT /protein_id="CAD09687.1" FT /translation="MSDEQHIGNDKSRYINAPKRTEVIHRSGLQGLKGQPRLKKLFTLH FT NGRKLEAEHIIVPAEKVELETTVHPLNPRNQEALSVNAVRDILKDIEARGVDTEGVAVK FT RNGVYLLIEGSRRRFCCIQSAKELPLWVLPDDVNADDINSIISATQTSRRFSYREVGLK FT YLREMEEHGFVTNEELANYHGISHVSVSKRVQAAKINSTLIALFPDYEAIPNSYYNRLF FT RLQKYIEKNLFSLEEVVENTREEIRDLDISDIAEAQKTVMEKITTVVEKLDIKPPSKGW FT DTRELATFTNKDKYARISKSSSGRKIRFEFNRMNRELIDEIEKFIKSKLSEMNN" FT CDS complement(59182..59574) FT /transl_table=11 FT /gene="HCM1.88c" FT /product="putative periplasmic protein" FT /note="HCM1.88c, possible periplasmic protein, len: 130 aa; FT identical to TR:AAD54039 (EMBL:AF105019) Salmonella typhi FT hypothetical protein from plasmid R27 (130 aa), fasta FT scores; E(): 0, 100.0% identity in 130 aa overlap. Contains FT a probable N-terminal signal sequence" FT /db_xref="UniProtKB/TrEMBL:Q9RGU5" FT /protein_id="CAD09688.1" FT /translation="MKYILTVLCIFFCQTASAYPYRIYTAPEGAIVKNILTNEVIGKTP FT VEVDVSNTEAGSTFGISMYRHENVAIKIFTVMPNAENNFTVSGPDVATMSLPGKAPLNV FT TNDSNAAAVHIDLRPFLSEPAHHPVQ" FT CDS complement(59571..60092) FT /transl_table=11 FT /gene="HCM1.89c" FT /product="putative lipoprotein" FT /note="HCM1.89c, possible lipoprotein, len: 173 aa; highly FT similar to TR:AAD54038 (EMBL:AF105019) Salmonella typhi FT hypothetical protein from plasmid R27 (173 aa), fasta FT scores; E(): 0, 99.4% identity in 173 aa overlap. Contains FT a possible N-terminal signal sequence and an appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT /db_xref="UniProtKB/TrEMBL:Q935P2" FT /protein_id="CAD09689.1" FT /translation="MIKVSAFILTLLVTGCQSVGSKIAVLPSVGFDPIMSNRTEAYTDG FT KVTFLIESSGTDVWLLAKNGTKEFIELSDLNLGGSRCTYSSRGKQLISPSSVTIFTVPT FT VGLLGLCYDNNDQLTFINNSFKNISQSSRDGLTLPLLFSIKYKFPGSFDSKQIVVTQSF FT DLEFLQKEQS" FT RBS complement(59580..59585) FT /note="possible RBS" FT misc_feature complement(60045..60077) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(60085..60924) FT /transl_table=11 FT /gene="HCM1.90c" FT /product="putative periplasmic protein" FT /note="HCM1.90c, possible periplasmic protein, len: 279 aa; FT identical to TR:AAD54037 (EMBL:AF105019) Salmonella typhi FT putative surface exclusion protein from plasmid R27 (279 FT aa), fasta scores; E(): 0, 100.0% identity in 279 aa FT overlap. Contains a probable N-terminal signal sequence" FT /db_xref="UniProtKB/TrEMBL:Q9RGU7" FT /protein_id="CAD09690.1" FT /translation="MLKLELIILPLLAFLGPSNITNASTKTPIPSSQLSDAKTGVNYEF FT ITIAANYVNGMWLVDGRQRPVIKTSMTKRNYLQIENDSASTPLNLVIPKIEFSIIAKNG FT VFISKFISLDEDASGKRILWLEPGSSMTISFVNDLSSTPLQALVSVTKQKKEVIAIFGP FT DQGKKFTLPLPSDSQQSSIDYVPSPEIALRINAPKKLQPAIAIPEDASASLLPSHTYKI FT RAAEKVRTFKFSSFVWVGKRNNLLGGSDYFTKELKIYPGENFDISTIQKTTMRTEND" FT CDS complement(60924..61895) FT /transl_table=11 FT /gene="HCM1.91c" FT /product="hypothetical protein" FT /note="HCM1.91c, hypothetical protein, len: 323 aa; FT identical to TR:AAD54036 (EMBL:AF105019) Salmonella typhi FT putative surface exclusion protein from plasmid R27 (323 FT aa), fasta scores; E(): 0, 100.0% identity in 323 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q9RGU8" FT /protein_id="CAD09691.1" FT /translation="MQFQKEAFMASEHVQTIDLTNFSGRVFFLADPHGHYSTLCNLIHS FT ISEPDEELIVFSTGNLFDYGPEPMELMTAINTGIFDGRSVRVFSAAGAGEEMLKKLLPI FT NKDRRTYYPSTFLNERWCARGGRWHKQINRNYLEEEICKLLSTQLATVMKVLFKGNISI FT GICPSDYTDIRQGFNNTYNALLAFNQANVNIFQSQFLYGMDHAVRPVNVSDVNLVVLGR FT NPVNSIRKAHGLPLTNLPVLIGNCLHINTGSLYMSEISSPALLAPGIPPTTVPAITLVE FT LILASTPTLICHQMILNKNGIYTQNTAPLNLDSNDNNIEATL" FT RBS complement(60935..60938) FT /note="possible RBS" FT CDS 62245..63279 FT /transl_table=11 FT /gene="HCM1.92" FT /product="putative plasmid stability/partition protein" FT /note="HCM1.92, possible plasmid stability/partition FT protein, len: 344 aa; identical to TR:AAD54035 FT (EMBL:AF105019), stbA, Salmonella typhi putative FT stability/partitioning protein from plasmid R27 (344 aa), FT fasta scores; E(): 0, 100.0% identity in 344 aa overlap. FT Similar to others e.g. SW:STBA_ECOLI (EMBL:X12777), stbA, FT Escherichia coli StbA protein from the stability locus of FT IncFII plasmid NR1 (320 aa), fasta scores; E(): 7.9e-28, FT 33.2% identity in 316 aa overlap" FT /db_xref="InterPro:IPR009440" FT /db_xref="UniProtKB/TrEMBL:Q9RGU9" FT /protein_id="CAD09692.1" FT /translation="MTELAKTKLAVAESNSTELETLKVVIDDGSKAAKLVCTNNQGDLV FT PLLTQNSFVADFRVSHDGLIPFNYLIDGLQRFSHHSESSNALETTDVAHQYDEISRLNV FT HHALHSSGLMPQDVHLYVTLPLSQFYTALGETNNENIQRKKDNLMKPVERYIDGKRVSF FT NVVSVTVFPESLPAVTRADEIESIESFESSLVIDLGGTTLDVASITGQLEQISSVRGFD FT RIGCSIVYDEIRRYLDSAKLNASNAYIHHLVDNRENKASLKVSPEDLDGVFNAVNGAVA FT QLQEKVIKAVTQVEERPHNVFLVGGGSYLIEPAVRKHFDKSKIIMVDNPQFALSLAIAD FT TVFA" FT RBS 63313..63316 FT /note="possible RBS" FT CDS 63323..64000 FT /transl_table=11 FT /gene="HCM1.93" FT /product="hypothetical protein" FT /note="HCM1.93, hypothetical protein, len: 225 aa; FT identical to TR:AAD54034 (EMBL:AF105019), orf B, Salmonella FT typhi hypothetical protein from plasmid R27 (225 aa), fasta FT scores; E(): 0, 99.1% identity in 225 aa overlap. FT N-terminal half similar to corresponding region of FT TR:P95794 (EMBL:U59131), orf B, Serratia marcescens FT hypothetical protein from plasmid R478 (206 aa), fasta FT scores; E(): 2.3e-20, 58.2% identity in 110 aa overlap" FT /db_xref="UniProtKB/TrEMBL:Q935P1" FT /protein_id="CAD09693.1" FT /translation="MTKKSEKENDRIQISAFWLSERQSPYAYNFLKKNSLTHRGEQISL FT IRSAITTGLVLNNLFPELSSFINGLNERLTAADLNRFFNDEFNKDKLNNENLKEQISFM FT LDSKFNELFSMINGCDFSKATFSTTSQSDVSETLKAERVRDQRLELIPKELTVNPKPET FT LEILTPIESAKKNDSGLNTSHGSAAVSASQSENTVLSEHAQIQGVTRKPKKKANANLAN FT LAK" FT CDS 64566..65018 FT /transl_table=11 FT /gene="htdA" FT /gene_synonym="HCM1.94" FT /product="transfer repressor" FT /note="HCM1.94, htdA, transfer repressor, len: 150 aa; FT identical to TR:Q52322 (EMBL:L20342), htdA, IncHI1 transfer FT repressor (150 aa), fasta scores; E(): 0, 100.0% identity FT in 150 aa overlap" FT /db_xref="UniProtKB/TrEMBL:Q7BRX1" FT /protein_id="CAD09694.1" FT /translation="MLSRNSLIHGLRRDQLIEVLSISEFPVVLVENPFIQPKSTGKKPV FT IFNIDEFHVSIAPISSLKYDWEWAPIDTILIEVVIPPAEADLVSAENDFLRDAGIGHIQ FT CEPGGVSIRRTVTFVGGITADNLLYQLRLMCVSALHLIGEELEDES" FT RBS 64996..64999 FT /note="possible RBS" FT CDS 65008..65442 FT /transl_table=11 FT /gene="htdF" FT /gene_synonym="HCM1.95" FT /product="putative periplasmic protein" FT /note="HCM1.95, htdF, possible periplasmic protein, len: FT 144 aa; identical to TR:AAD54032 (EMBL:AF105019), htdF, FT Salmonella typhi protein from plasmid R27 (144 aa), fasta FT scores; E(): 0, 100.0% identity in 144 aa overlap. Contains FT a possible N-terminal signal sequence" FT /db_xref="UniProtKB/TrEMBL:Q7BRX2" FT /protein_id="CAD09695.1" FT /translation="MKVNFKKVIPLLMVGLTVAGSYSIFNAKPSKPDLYDFTGKVLKTT FT SVFQPCDKESTPSLNIQIADNGSVHINGVASKVTFVERVPGNEIAVKCTGLQVKNSRLV FT HTSSYTMIISEGKGGFVISDLTHTKDNEVMSGTWFFKKRV" FT CDS 65439..66002 FT /transl_table=11 FT /gene="htdK" FT /gene_synonym="HCM1.96" FT /product="hypothetical protein" FT /note="HCM1.96, htdK, hypothetical protein, len: 187 aa; FT identical to TR:AAD54031 (EMBL:AF105019), htdK, Salmonella FT typhi protein from plasmid R27 (187 aa), fasta scores; E(): FT 0, 100.0% identity in 187 aa overlap and similar to FT TR:P95792 (EMBL:U59129), htdK, Serratia marcescens protein FT from plasmid R478 (177 aa), fasta scores; E(): 0, 51.1% FT identity in 178 aa overlap" FT /db_xref="UniProtKB/TrEMBL:Q9RGV1" FT /protein_id="CAD09696.1" FT /translation="MTMSDLSATGAKPQRVRVFSQSVAMAFEVNLDKSRSADNSAFVTE FT TEKYYLSLQFAPPSDNREYGWNSEGSILMKLSQNEAMALASVFLRIKPTLKFEKRKTTH FT RTHQAYKNINIGPNDRGGLLVSASIVPVKMGTFKPLNYNLPVTQMDCVSTGLFLLGFLT FT LKMPWVSSESIITALRLSESKSGQ" FT CDS 66122..70420 FT /transl_table=11 FT /gene="HCM1.97" FT /product="putative periplasmic protein" FT /note="HCM1.97, possible periplasmic protein, len: 1432 aa; FT N-terminal 960 aa highly similar to TR:AAD54030 FT (EMBL:AF105019) Salmonella typhi hypothetical protein from FT plasmid R27 (960 aa), fasta scores; E(): 0,99.8% identity FT in 950 aa overlap and C-terminal 439 aa highly similar to FT the adjacent R27 ORF TR:AAD54029 (EMBL:AF105019) Salmonella FT typhi hypothetical protein from plasmid R27 (439 aa), fasta FT scores; E(): 0, 99.8% identity in 439 aa overlap. Contains FT a possible N-terminal signal sequence" FT /db_xref="UniProtKB/TrEMBL:Q935P0" FT /protein_id="CAD09697.1" FT /translation="MRKSGLCLTLLFSLIASIKSVQAEAIMISGKLQADMPAVTFNPGP FT GDFVAFVNNNTITASGTGNACNVTVDDRATSSVDNLVCFFEWLPNTSGFTANGFNLTGI FT PNAAGELKLPYKISYFSGSERQKVEVVNGEYTVNALVPVKPTITGLKSSMNGVVQDGYT FT LKSYLKDEAIRNVTVSVEPRNYVQYISIGSGSACEVAIGGNGCTIDVGSIKVSDSDLLM FT GSREITVTANSKNNYFAPPEAQKLTLTWDYRPPVVDHTLWNFTDEAKTISVGGQEIYTG FT ARTVAVAVKVPQEGTEGEWWLPTAMTLTMNPDGVFKPTTKVTLEDGTVIDFKQSWATPL FT RRTLQPVSGPQKVGDEYLYIFDLTDLTNGSYAASFTVENNSKNTSTYNEPESKLMLSDN FT PTLMVLKDGAALAKRAPVYFLNEIIVAAFQGQAGVADIKAVTIDNKLVELTPTNHKGIY FT YLPVGDDLEVNADHEITVIAENLYGKIVTFNTTFTYQPTGFTLKNFEKDITLYSRVRQY FT TDLMSQTAGDKCTLFTTEENALAYLEWYGDKSDITACYPQWNNVPDGLEFYFKGRTPGL FT TGFFNKTGDNLLDYQVYMINGKGSKAVSSRNRHVLITQLPYNPVLTYKKNKVLTGINDN FT TALAYTTGGEAARLLAKVVPADVTVYVSQNGGESVKTTFKNRSSNNDATTFVQRLKVAS FT APLWTKNVFDIAVEYSKEPTMRTVDTLNVYTVPDFNIRAAMEIEDKKTATTMELPLKVS FT VGRYNNSTRKSSFSRTTMGDWDVTIYAQKSVYGKDPETGRYKTTYERTPLTEALPVNDA FT GVVETKIKIENMDLGNVRLVGIAKVRSPFADFELTRETSAVSIRVYKGEELEGNLSKSL FT IIGRIPLSTLVNFKSASTANSDALAPTEWQESSDNGQTWTMLQDMTGKRSISIRKTEVG FT KWLYRAKMTNKFTSKESYSDVLTVVTYKQPKLSIDVAEILEGDDLPVTLLDNDEPIPQG FT TAEVMWSEDKVNWVQGDTTYNVSAADTLPPTIYARMRYLDSDELAEESSWKETSARLTV FT AKPKRLSVSVSGISSVEVGSKVTLDGKYTNPNSRFKNGNDVIEEWTAPDGQKIRGANLS FT ITLTEQMLDKQGYAAFEYSAWLADSKDSTISTRKVSVKSWVYKFPEMKVSTKLKYTMAP FT STLHVALSGIKDGGYPGVTYSREWIYDKDNISVLKDDGDTKEFAIAKPGKYTLVIVFRD FT NRNNEQRIENTFVVDEQTPMTVEMTPKFSNKFMRAPLDVTLRSNIKLAHSADSIDTVTY FT KVNGEVVPGSKNYWAQLISGLTEKKYEVTLDVVSKMGQRGTASVDFEVVKNAAPQCALS FT YTESNMSWSFTNKCIDTDGKLVRYEWYINDELRNVFGSTATLSKNLNRGKQDIRVVAYD FT DSGDSATQRTTVYGPDEGASKSVDSVETSQ" FT CDS 70694..71206 FT /transl_table=11 FT /gene="trhF" FT /gene_synonym="HCM1.98" FT /product="putative pilin maturation protein" FT /note="HCM1.98, trhF, possible pilin maturation protein, FT len: 170 aa; highly similar to TR:AAD54027 (EMBL:AF105019), FT trhF, Salmonella typhi plasmid transfer protein from FT plasmid R27 (170 aa), fasta scores; E(): 0, 99.4% identity FT in 170 aa overlap. Shows weak similarity to signal FT peptidases e.g. SW:LEPC_BACCL (EMBL:Z27457), sipC, Bacillus FT caldolyticus signal peptidase I from plasmids pTA1015 and FT pTA1040 (182 aa), fasta scores; E(): 0.013, 25.1% identity FT in 171 aa overlap. Appears to be missing the proposed FT catalytic serine residue of IncP transfer system signal FT peptidases, therefore may not be active. Contains Pfam FT match to entry PF00461 Peptidase_S26, Signal peptidase I. FT Contains hydrophobic, possible membrane-spanning region FT near the N-terminus" FT /db_xref="InterPro:IPR011056" FT /db_xref="InterPro:IPR015927" FT /db_xref="UniProtKB/TrEMBL:Q935N9" FT /protein_id="CAD09698.1" FT /translation="MREYIPKKRGLLSFDWYVPINLGILILVMLIFFNRFTFGHGLLNG FT CLPADFYMIDLKDKSVSSGNIIAFHMPKSVRFIRENEKVIKIVAGVGGDRLRVTLDGVY FT NGNKFYKANARRISVKYGIPAETIERELTIPEGEVFLIGQTDHSWDSRFWGPVKLTSVI FT GKTYAIF" FT misc_feature 71096..71185 FT /note="Pfam match to entry PF00461 Peptidase_S26, Signal FT peptidase I, score 15.50, E-value 0.0009" FT CDS 71193..72701 FT /transl_table=11 FT /gene="trhW" FT /gene_synonym="HCM1.99" FT /product="plasmid transfer protein" FT /note="HCM1.99, trhW, plasmid transfer protein, len: 506 FT aa; highly similar to TR:AAD54026 (EMBL:AF105019), trhW, FT Salmonella typhi plasmid transfer protein from plasmid R27 FT (502 aa), fasta scores; E(): 0, 99.8% identity in 502 aa FT overlap. R27 trhW shown to be involved in plasmid transfer FT by mini-Tn10 knockout. C-terminal half shows weak FT similarity to SW:TRAW_ECOLI (EMBL:M93106), traW, FT Escherichia coli F-pilus assembly protein (210 aa), fasta FT scores; E(): 1.8e-05, 25.4% identity in 193 aa overlap. FT Contains a probable N-terminal signal sequence" FT /db_xref="InterPro:IPR019106" FT /db_xref="UniProtKB/TrEMBL:Q935N8" FT /protein_id="CAD09699.1" FT /translation="MRSFELKTTIKPLASCLAFYALISTAVASPQYQQVADDIARQAQV FT LGAQIPVPHASEGPLPSGSLDSPDTKKYIRQAEAMKKNGDLSQQTNRGYVPGMNADSVQ FT AVIDHTQAIRAQSNNSEAVNDIIRRRDEIQGNSQLSESALKSVENKPEVMRSQSSNIEK FT MFGSSGITAADFERKIDSSREEVLSTENGITIFASFSLPDYVLEDLLRTASEHKARVVF FT NGLKKGTTRLPETQAAINQLVVKGKFDSPLITIDPDAFNQYQITQVPTIISREQSRFAK FT MVGSFNVDFFQRELARKPDQDLFPIAGTTYPVEEKSIIKELEERAQKYDWDGAKKRAVA FT DTWKNQYMVNLPPAQEHKEWLIDPTIRVTQDVKDKQGRVIASAGELINPLARFPQNLTM FT IIFDPMNPGQLEWAEKQYRQRLGSGQVMPMFTRIKQENGWDHLNDLREKFNGKVFKVNE FT QIIARFQIKNTPALISTEKEKFRITQFSEAEIRGIGTKIAAEEN" FT CDS 72891..73898 FT /transl_table=11 FT /gene="trhU" FT /gene_synonym="HCM1.100" FT /product="plasmid transfer protein" FT /note="HCM1.100, trhU, plasmid transfer protein, len: 335 FT aa; identical to TR:AAD54025 (EMBL:AF105019), trhU, FT Salmonella typhi plasmid transfer protein from plasmid R27 FT (335 aa), fasta scores; E(): 0, 100.0% identity in 335 aa FT overlap. R27 trhU shown to be involved in plasmid transfer FT by mini-Tn10 knockout. Similar to others e.g. SW:TRAU_ECOLI FT (EMBL:M34695), traU, Escherichia coli F-plasmid conjugative FT transfer protein (330 aa), fasta scores; E(): 0, 32.9% FT identity in 322 aa overlap" FT /db_xref="InterPro:IPR009649" FT /db_xref="UniProtKB/TrEMBL:Q9RGV7" FT /protein_id="CAD09700.1" FT /translation="MLSLSLPAMTMAADTGVPGAMCQSAGVWQGLIKNICWSCIFPMRI FT MGIGAAPEGAAPSRPGCYCTDQNGIPEIGWQLSFFQPVKIVEVVKSPWCSPFLEGTMLQ FT KSQFDIGKSNTNQPMTATEAGFYDVHLWEFPIMTMLKLLVIGECTAEPYVDASLTYISE FT VDPMWESDLLTLVLNPEAVVFANPIASMVCAADCVAVTAGKDNLAAYFCAGCDGNLYPL FT TGHIYANDDAVRTSSLITQRLLTKLHRQGMLMRTMGADAMCEKTWEYFTPRSQYRLSML FT YPTPEANGPDCCHRLGDSVHDWSTLKGGRKKIGIDNYVYMLWRYNDCCVRYIPN" FT CDS 73921..77097 FT /transl_table=11 FT /gene="trhN" FT /gene_synonym="HCM1.101" FT /product="plasmid transfer protein" FT /note="HCM1.101, trhN, plasmid transfer protein, len: 1058 FT aa; identical to TR:AAD54024 (EMBL:AF105019), trhN, FT Salmonella typhi plasmid transfer protein from plasmid R27 FT (1058 aa), fasta scores; E(): 0, 100.0% identity in 1058 aa FT overlap. R27 trhN shown to be involved in plasmid transfer FT by mini-Tn10 knockout. Contains a possible N-terminal FT signal sequence" FT /db_xref="InterPro:IPR009726" FT /db_xref="UniProtKB/TrEMBL:Q9RGV8" FT /protein_id="CAD09701.1" FT /translation="MKHRKIISSAIIASMIANTMSWAFYVSLINIALTPKIFAADAIFD FT QLENNFNLANPNANRNATTSAQDIVEKYKNADSGENLSGKISEKYVGKAESTNLNVGKY FT GTPNSNESVMSNAVSDGKSIGKAVQLPSMSGGTINSNYTKEGAKLLSRDSSGNIGISNN FT PNTTAGTKTSTGELFSSEQKHSDVQFNAGGRYGDENGFINDIKNRKSQLFEAQSYDGVA FT YRTLVNANKENPASTIKPNDPMFNAGRNEIGNAVAGTGNWLQNCNTETSKQTITTHYPD FT YKEFYCNSPKKDNFNSCTITRDFSVPVYISGGNGDMSMCGDNCVRVWFGRRDDNYWNDG FT VYDNSLTLKFHPDAKLATAKIINAEWDDHMRVTLDGTQIFAHIDGAYRSSNYPSPQGQW FT ELKKSWKLDKVYDITEQVKTSVYQEQDREVTMASRVWVGGGGEGYFEVEMTFENMKLED FT KHIQEPAGCFDAVQTPNSFCRFDRFVNMDVGTKRLPESVLKMATPLYKGDTGYLTWKTN FT LEGYFCDPLAKEKLCSYDAKGNIMKDPTGKDLCYNYDDIKNMPDACSTYKNDAACVLDN FT QTCAEGWFDEGTNTCYMYEQKYTCDRGKDVVREVESQTNSCVGMIPCSGGTCETGPKEE FT NKDFGKVAAYSNMVQYMQGEAKCEDPNDPNSCSVFEGKAEWCGRSVGFVNGLAKTDCCE FT KPQGAAGSLEAIMLAGSMIRNTNWTRVNAQLVNWTGGESGTWASMANSVGEWTASAGKT FT VGQMWNNVTSSITSVYENVAGNLGRTVGSSAAGESGQLAKETMSSFGLGKLKQMAMEKA FT YDLLPDTVRDFVFKNVATTGGEIVFSAAVQNFMLALNVIGWIYTAYQVTKMLLEMLVAC FT DQKEMEASIHKNQKSCFTLDTNRCVKYLNLGFTKKCVKKATDMCCYNSMLSRVIMQQAY FT PQLGIDPVTSNCVGLSIGQIQKLDFDKIDLTEWINDAVQVGEVPDQYATFSESSITANL FT PFKNENYQLPSERTKDAMGGEENMIKARQENAQAIKEENVDCSYLPRPAICEVGSTYVD FT PITGKEIPKY" FT RBS 77418..77422 FT /note="possible RBS" FT CDS 77433..78419 FT /transl_table=11 FT /gene="HCM1.102" FT /product="hypothetical protein" FT /note="HCM1.102, hypothetical protein, len: 328 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935N7" FT /protein_id="CAD09702.1" FT /translation="MTTQSSSIQYAYALDGEGTLTHIGAALRSHTYTCPGCKSPLTPVM FT GEFNAKHFRHSEECCALETYLHKCGKEAFFYRYQQALSREMPISLELERRVACNGSHLA FT LVRDEARQCVKSVPARYNLTQFFDQAELEKHDKVTGLRPDVMLYDTTGERRCYVEICVT FT HPCSQDKIEAGIPILEFKVQSASDIQMLLTGAYSIKEKILRVFNWLPPFQSVDTCSGVC FT SVGNVYMSVWSLSGSGRLYEQTMPLAEVDLTINSDVNTWPRSLGAAELADNLRAFIRHA FT DPHSLFPNCIMCEQAGRWEDGYLQCHSKAKIVPYTEARQCANYKVKA" FT CDS 78416..80455 FT /transl_table=11 FT /gene="HCM1.103" FT /product="putative DNA helicase" FT /note="HCM1.103, possible DNA helicase, len: 679 aa; FT similar to several e.g. TR:O24736 (EMBL:AB001291), uvrD, FT Thermus aquaticus DNA helicase (692 aa), fasta scores; E(): FT 6.5e-21, 28.1% identity in 627 aa overlap. Contains Pfam FT match to entry PF00580 UvrD-helicase, UvrD/REP helicase and FT PS00017 ATP/GTP-binding site motif A (P-loop). Similar to FT HCM1.107, trhI, probable DNA helicase (618 aa), fasta FT scores; E(): 1.1e-08, 23.2% identity in 621 aa overlap" FT /db_xref="GOA:Q935N6" FT /db_xref="HSSP:1PJR" FT /db_xref="InterPro:IPR000212" FT /db_xref="InterPro:IPR014016" FT /db_xref="InterPro:IPR014017" FT /db_xref="UniProtKB/TrEMBL:Q935N6" FT /protein_id="CAD09703.1" FT /translation="MTKRLTWEQKSIVNHDTGHALVKAVPGSGKTTTLVKRVERLVKTG FT TDPRSILILMYNKSAQVSFTEKLKTALMSSVIPEIRTFHSLALKIVGYGERQQIIKKKD FT LITPSDYRYEQLVKQAYRYGFDHEANYIDPNEIENFELFIARCRAAAVTPVDAANDPTF FT SNIKRGFIHAYGRYCELLEENSLRTFDDCLIEAVALLRNDSSLGAHFKHIIVDEYQDVN FT LIQHDMTRLLSKSDTSVMAVGDVNQCIYEWRGARPDFIGGLFERHYPNTKVFQLSCTFR FT FGHELSLMANSVIRRNSTKLTKLCVSHPSTPKTEVRLHFDNCLSKVLSNLSVSSGTQAI FT LSRTKANLAEAEIVLRLCGLPYRYLNGSSALHTRTEIGILVVGVLLSVYGDLRLLENHP FT NKQAIVYGFLKEAGFSWQKGQFKAALSGLMAPHADLWSALGQLFEGAQYQKDRLGRLAT FT ICQKDGEETPAIDVLRRLSMEGFIDSVGSEGVTRTGSNDQQRGVVRIGELLDSSKIDSR FT TFLNLILNPGEAATDCDPFILSTLHGSKGLEWDNVILIGLNEQEFPGGKPDDVYSVRTS FT MNTPPAEEEIEEERRLFYVGITRTKQQLNLVVPLDEGLARWLKNRWDSTPKKSPIATRF FT VYEAGWTACAVTSDAIYNSTVEKQKADFSKFHQWYLRDLQRLKV" FT misc_feature 78431..79864 FT /note="Pfam match to entry PF00580 UvrD-helicase, UvrD/REP FT helicase, score 19.30, E-value 3.2e-09" FT misc_feature 78485..78508 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS complement(80458..80712) FT /transl_table=11 FT /gene="HCM1.104c" FT /product="hypothetical protein" FT /note="HCM1.104c, hypothetical protein, len: 84 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935N5" FT /protein_id="CAD09704.1" FT /translation="MLALGVSYPPKSGWIERLIGTEVSDEQYERFLGHSTSKQAEQILR FT GEQPAKGLQYAKRAKKLASERKATIDLDNEHLSEIEKYR" FT CDS complement(81234..82106) FT /transl_table=11 FT /gene="HCM1.106c" FT /product="putative lipoprotein" FT /note="HCM1.106c, possible lipoprotein, len: 290 aa; FT identical to TR:AAD54023 (EMBL:AF105019) Salmonella typhi FT hypothetical protein from plasmid R27 (290 aa), fasta FT scores; E(): 0, 100.0% identity in 290 aa overlap. Contains FT a probable N-terminal signal sequence and an appropriately FT positioned PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT /db_xref="UniProtKB/TrEMBL:Q9RGV9" FT /protein_id="CAD09705.1" FT /translation="MKNKRFVSLVSALVASASLVGCAGNAGQSPNSAQHSDTHGLYWHA FT NAKDSVAKNAYSLAGFDVSFNEETVQPGGDADNFLSKLLISGSMGYVTGGLSGLSIMSL FT GSLYSSSDAEYIQVNQYVVFVPNPKKLPYNDESLVRAGAAYVYNHTKESQVMLGFNPSK FT QSAALASCKIDRAVINKWSTCELTSKPAPDVMPTNSMYSFQAIRPATGTEIPQLNLPAG FT EYSVIRYVFIPFKGNESSNNFSGIIFRSDSPKFTMPGGAAASINGKDYYLFSGEYGQKG FT FPEKTLKSK" FT misc_feature complement(82041..82073) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS 82216..84072 FT /transl_table=11 FT /gene="trhI" FT /gene_synonym="HCM1.107" FT /product="putative DNA helicase" FT /note="HCM1.107, trhI, probable DNA helicase, len: 618 aa; FT identical to TR:AAD54022 (EMBL:AF105019), trhI, Salmonella FT typhi putative ATP-dependent helicase from plasmid R27 (618 FT aa), fasta scores; E(): 0, 100.0% identity in 618 aa FT overlap. Similar to others e.g. TR:O24736 (EMBL:AB001291), FT uvrD, Thermus aquaticus DNA helicase (692 aa), fasta FT scores; E(): 1.1e-13, 25.0% identity in 645 aa overlap. FT Contains Pfam match to entry PF00580 UvrD-helicase, FT UvrD/REP helicase and PS00017 ATP/GTP-binding site motif A FT (P-loop). Similar to HCM1.103, possible DNA helicase (679 FT aa), fasta scores; E(): 1.4e-08, 23.2% identity in 621 aa FT overlap" FT /db_xref="GOA:Q9RGW0" FT /db_xref="HSSP:1UAA" FT /db_xref="InterPro:IPR000212" FT /db_xref="InterPro:IPR014016" FT /db_xref="InterPro:IPR014017" FT /db_xref="UniProtKB/TrEMBL:Q9RGW0" FT /protein_id="CAD09706.1" FT /translation="MSLVKKNPSNLNRIIKGTKYSEAFMGKPTDEQRVIIENANANNMV FT IAAPGSGKSFTMIEAVISILRQFPYAKVGMVTFTRAATNSLAEKLKRRLSKKDQDRVLV FT NTFHGFIRMQLDMVNWKGKMLISSAQRSVIHRALKESGAPFRYPDAEFAIDAIGREMDT FT DIISVRHTRQQIHLFNTYQAICQKDHVADLNALSRFVVGQMYSGKMQPLNLTHLVVDEV FT QDTDSIQYAWISLHTRAGVNTSIVGDDDQAIYSFRASGGVKIFQQFEKQFRPNIFYLNT FT CFRCEPEILKVAGALIEKNVYRYAKDLRSAKGGGGKVHFRSYVDMDEQIQGILNLINQD FT PIGWAILSRGNAHLDQLESLIEQPVLRYGGKSFWDEKETSDVLHLMAFFRHSNDVRLMK FT RVLALFGENEEVLDQTALSMKGRKVTFGELNIPNESSLETRTLHSNFTRFTQETREKVE FT IEKRFANLIKWMELSSIKMRTQKGSPSLSRIALDTCKQWAEKTGWQNMINRAAAMCLGP FT KKKDEEYTPDKVVLSTLHGSKGLEWKNVIIMSCNADQIPSKRSVGQEAIEEERRLLFVG FT FTRAEQQLHVMWYGDPSFFLSECAEDKLKEAAKSRTESPLTE" FT misc_feature 82300..83610 FT /note="Pfam match to entry PF00580 UvrD-helicase, UvrD/REP FT helicase, score -7.10, E-value 2.9e-08" FT misc_feature 82354..82377 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 84470..85345 FT /transl_table=11 FT /gene="HCM1.108" FT /product="putative membrane protein" FT /note="HCM1.108, possible membrane protein, len: 291 aa; FT unknown function, Contains hydrophobic, possible FT membrane-spanning region near C-terminus" FT /db_xref="UniProtKB/TrEMBL:Q9L5V4" FT /protein_id="CAD09707.1" FT /translation="MSKSKARSKALLIAFADLIPDMDKVVNKKLLDSLNVYSGHDNDLI FT VIMNEDGPTIIELNSLKSVSMLAQKLSAFSTYYHVEMQQILVNPIDFEKAYTLLKEAPA FT IPMFKTLADLDKFLNEEFEKYGLNTFLDVDNLDYSLAKSRELKNDQLVAWVSEIIEKRE FT KLALRNRFNEVTKAHYETVDAMYAAVRPLMKELGFPDELMLHTFSELSVFDSKGWDYAI FT KSKIEFLTKREEQCLDYQMKADKRQATVDELLAQINNAKTVKAPRSFGQLFGFSVIAMM FT TFMFIVNKFI" FT RBS 85392..85396 FT /note="possible RBS" FT CDS 85404..85781 FT /transl_table=11 FT /gene="HCM1.109" FT /product="hypothetical protein" FT /note="HCM1.109, hypothetical protein, len: 125 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5V5" FT /protein_id="CAD09708.1" FT /translation="MSYLEYVNEVKVSGIVISAMEKEMTSGNVGLLIKLKNRMKTEING FT EITEREFSIQIKVSPEMYSGCFTGINQGDELMVSGYLVVDTITLEGREHPLDYMRVVAT FT SKLAHIPKPPKGFGQSSFRQI" FT RBS 85832..85836 FT /note="possible RBS" FT CDS 85842..86828 FT /transl_table=11 FT /gene="HCM1.110" FT /product="hypothetical protein" FT /note="HCM1.110, hypothetical protein, len: 328 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5D8" FT /protein_id="CAD09709.1" FT /translation="MKQKIRPTAFCSKQMDFFSIFDFEEEEKEIITIVESPLDYINDAI FT AAQQSIQSEDKHSGPELEPSVSEDVALPGNCPKLLKNQILHDISFAAETDYLFTLEEYS FT AELGGLVFDWAPEDVYQLYVVAMEESLENVRHLVITKSLYSTDEFGNITVNPLLEAETR FT WYMSKSFELTCATHGIDAIEFRSELKKSLYEYTHSYGGENAELARYHQDKEVILHDCKE FT EMGWDIFFEQDYLLQENKLAMKWTDRDIMDVYSKVFKSTINLFEKLVVNNKLTLRDTFG FT WVIVNPTFERQFEWIESEVFEIVGTHLGYNVAAIRTQMATACRMTFH" FT RBS 86876..86879 FT /note="possible RBS" FT CDS 86888..87940 FT /transl_table=11 FT /gene="HCM1.111" FT /product="hypothetical protein" FT /note="HCM1.111, hypothetical protein, len: 350 aa; shows FT weak similarity SW:COBS_PSEDE (EMBL:M62869), cobS, FT Pseudomonas denitrificans cobalamin biosynthesis protein FT (332 aa), fasta scores; E(): 8.4e-06, 21.4% identity in 308 FT aa overlap and its homologues. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop)" FT /db_xref="GOA:Q935N4" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR011704" FT /db_xref="UniProtKB/TrEMBL:Q935N4" FT /protein_id="CAD09710.1" FT /translation="MTNAATVLKSDNSVQEEIIGNLLPANVISSKMFANKEQYYLVKAK FT DLFGIPEMDEDMIVPVFKKFSPYRANLNKDYIPNSRILEQVVKLLVSNDIDLSVCLKGE FT SGSGKTEMAMYISHMLNWPLTIKQINSNIRADELEGERSLINGNTSFVPSELVTAFQEG FT HLILLDEVDKIDPDTAAKLHMPIERKPWSLAANGGEVVKANKFTRFMGTSNTNMSGGSR FT KFVSSQRQDAAFIKRFLIVEMERPSEVALTNVLLKRYNNLPMLVIEKFVSVAVAVNNTG FT TDDSVMDIRQLVAWVGTSMTLKTMSLLDTFKIAFASALPAHATGMVLEAIDLILGDDKN FT RTMEYYTAKK" FT misc_feature 87194..87217 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 87979..88248 FT /transl_table=11 FT /gene="HCM1.112" FT /product="hypothetical protein" FT /note="HCM1.112, hypothetical protein, len: 89 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5E0" FT /protein_id="CAD09711.1" FT /translation="MTDFAHLTFYGFLSANGTETFVIAQDGNQYIGLKQHNNDYSFICY FT EVCNKDMEAMIKGLESKGFMYQGSIQSADVENEFPGILLTTLEK" FT RBS 88308..88311 FT /note="possible RBS" FT CDS 88319..89446 FT /transl_table=11 FT /gene="HCM1.114" FT /product="hypothetical protein" FT /note="HCM1.114, hypothetical protein, len: 375 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5E1" FT /protein_id="CAD09712.1" FT /translation="MTFNTSKLNKVSAKEISENFIKAYPDLQEGAVITKIEISGCQGSR FT RTDKIELSYGGDDITDQKSVSKSEVRWIDIKALSFKSTITSRISTLCSRLCIRYSNMWI FT LPVERMEEFLEEAQEIEREFQAGIQNVVDNYDTHIQAEKDRSPLMSDLIDQLKLTKDDF FT VKSFRFNLAHFIPFSPISVEGDETQDFYQEQLITDLADEAMKVYTKISKNDNLRSSTID FT RLKQMQDKIISFMFIHKEAVVLAEAIKHIMNNLPKGAISSPRDVAVLKQWFYFMSDASM FT LKRIISGEQKVTDWLDSITRSFNIDSQVTAANSLNTAEDDVFSSANVFREDPVEDLENK FT AVNAPEPAVGPDEDVSIQASGSNRAFDCELELTGW" FT CDS 89524..91536 FT /transl_table=11 FT /gene="HCM1.116" FT /product="hypothetical protein" FT /note="HCM1.116, hypothetical protein, len: 670 aa; unknown FT function" FT /db_xref="InterPro:IPR002035" FT /db_xref="UniProtKB/TrEMBL:Q9L5E2" FT /protein_id="CAD09713.1" FT /translation="MKFDLKSSPRHIQRLTNIASVISGINGIYVIIDNKVSTPYFNTQN FT NVCVLPNGDYSDERFVKLIEGFICHEAGHGRYTEHEVYREAFVGELINADGFISIDDDL FT KADFQNLKQKQKAYARACRLKGLINLFDDVQMEEKTGIDYQEAKKRLAVTYALMVEAGR FT MTVDISSTPQNPVQFIEMYLLNTLRVNVLQQEGHKETLDPFFDYAKKILAPVTSEVDEI FT IHQALSCKSTQNCDSLARKTLALLERLRDEAKEKQQEEEQSKDPHDDTDESSGSENEPD FT TEPNGDSQGEGDGDKEGQGDDSGDGKAPAEGNGLPDQSGGDEQNAENSNGEPDGESEGD FT ESATPGSDDADSTPSLNDSSNGNSSDGESNFSPEQWDMLAKLLDDFLNSDEESEDFHEV FT LAKEISVIAASVSDEVKAEFGASEWDVPDLNIDLNVYNEALNISQTLGADLSVLQQVKM FT RGQFKTRDRGLSFDINRLIQSPMGVRDVFRSQSESKNRGHVGLVIVRDISGSMSLEHRY FT IHAIKTDLALTLAIEAISKMHVANVIYPFVDKDFEVIKTFDENAEEKLSKFSLGCKGNN FT TPTGSALNAALELLLESQFDRKIVFLITDGYPTESAYTINDVFSVAESNGIEIAGVGIK FT TDVLMGFNEGTFVNVDDISLLPNEVSKLVHQILSN" FT RBS 91595..91601 FT /note="possible RBS" FT CDS 91608..91829 FT /transl_table=11 FT /gene="HCM1.116a" FT /product="hypothetical protein" FT /note="HCM1.116a, hypothetical protein, len: 73 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5E3" FT /protein_id="CAD09714.1" FT /translation="MTQIKTYRVEYEKVGTMHRVRIFGRMGEIVKSELPEERILRDVSI FT PEGNGEMATSMVDGFIQRLENIGFKTEA" FT CDS 91923..93176 FT /transl_table=11 FT /gene="HCM1.117" FT /product="hypothetical protein" FT /note="HCM1.117, hypothetical protein, len: 417 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935N3" FT /protein_id="CAD09715.1" FT /translation="MPDKREQMTYASQAVKRTPHEVTDHFIKMVHARIAEVSGWRYVFD FT RIPAFKDACDKAPGQVPCPFSGVGKSKFRFRKKDLFTGCAIHNDFPVNAFCDGIDVLAE FT YYKLSKTQTCKKILTDFFGMDLYAPLTDADLESERRYKSTVRATETLDSDEVEKRGRKL FT EVIYHYTGEIKPESPVWVYLRNRGLNRVLSNLPKDLGLNKRLYYMDKSLEKPTIYPGMI FT AIYRDTRGRPLTIHRTFVELNGDKAHVENPKLMMKPPADMTGGSIQLYDPHFNPGTRTW FT TLGVAEGIENALSVTEATSTPCWAASSAWCLENVEVPDSLLPPPGVKVIQFYIWADKDL FT VNTKGTSPGMESAKRLQERMKEFFAKRYPTSELTIKVFEPDFDIPVGKKGVDWNDVLKL FT TGPDGFPVKWAPECLAQL" FT RBS 93438..93441 FT /note="possible RBS" FT CDS 93451..93975 FT /transl_table=11 FT /gene="HCM1.118" FT /product="hypothetical protein" FT /note="HCM1.118, hypothetical protein, len: 174 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5E5" FT /protein_id="CAD09716.1" FT /translation="MNIENQDLFNTFAAVISSHIVEQPSSCYYLHDNEIDFTILKHSII FT DKDKNLLYVIRPSGTCLLRCDKYFFPNYYLTSRGDYKAFKYVHFNLATREAEEITWQQA FT FEILSKPGRPPLRGSLGKFDYLKLVIDDLRARGYADFLPAYNLDGLRHFAVKDERPSLV FT SYIDNVMALCA" FT CDS 93966..94931 FT /transl_table=11 FT /gene="HCM1.119" FT /product="hypothetical protein" FT /note="HCM1.119, hypothetical protein, len: 321 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935N2" FT /protein_id="CAD09717.1" FT /translation="MRIKITHIFTTSLMAPPIGVALRVESGGLMKLATDLVNAVLIKNG FT IVPTSINELPVTSLVKPLTQVHLSLYLKTTHLSQFVPDYVESLKDCPVSYDIGLELQQC FT INSAELLCEDMESLEFISVWIELYTCNSKQQRFEKSNFSFRTEDIELAKMLSCSHEILI FT SQAACFWLLYFEDFMKYVRNRLCALLRQVLILIAGLRNVYLQRNEDQLIKRVKHGNEML FT EVTLKAVALCSIERYLKSYASLRTEAAASGFIKCIQSYISTGWRHGYIVCQYSKNGRSL FT GKSLPLFIKETSEHNIQKRVNRLISSTISGRNKDLGLYDF" FT RBS 94993..94996 FT /note="possible RBS" FT CDS 95002..95937 FT /transl_table=11 FT /gene="HCM1.120" FT /product="hypothetical protein" FT /note="HCM1.120, hypothetical protein, len: 311 aa; unknown FT function. Similar to HCM1.121, hypothetical protein (306 FT aa), fasta scores; E(): 2.8e-07, 22.4% identity in 254 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q9L5E7" FT /protein_id="CAD09718.1" FT /translation="MKIIEKIINAFLISRKHSVKVSNVICLSGTDGKFTGICCDADVSF FT DFLYSYAPAYSSTFLDIPFPGFEDQDIADCVKCQLDVVKNKRNRSFLIDHIRFPVSSRE FT GFTLTRGDSYDVTECEYNKERLLHLTRQGRFCEDYLTFKDGLSSFFSFVNFELHEIVKE FT GIRLALDVLNKITSDQPDRLIKDFKYHDCFGSYNVQIFSKGLPVDILETMIAPDRLLSN FT LSGSRQIMKNASRYLKGFALSNRVYMKYGWRLADVDTSDYAKVMSDREMHARDDLKAFC FT SVFFKECFASGKYEYEAYLSERQHAIRNGY" FT RBS 96003..96006 FT /note="possible RBS" FT CDS 96015..96935 FT /transl_table=11 FT /gene="HCM1.121" FT /product="hypothetical protein" FT /note="HCM1.121, hypothetical protein, len: 306 aa; unknown FT function. Similar to HCM1.120, hypothetical protein (311 FT aa), fasta scores; E(): 7.1e-06, 22.4% identity in 254 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q9L5E8" FT /protein_id="CAD09719.1" FT /translation="MKAIYKIIEAMLVKMGFEGAVIQSVNLETGVIQSLVVKADIPVRT FT LMPHLRRYLRDCEPLWGHDVDYHPIAQYCSGAALLKAGPVTLETFRFEVSVSTAHLRLV FT DVEPDCLNEGVNREKLEYVYYRSSNADKDLILGMVEKGHNFINHLHELLRSRLSTALPL FT IFAVTEKIAESSVPQVVTSFFSVDHQINAQIVVEPVPVSVADQIISADWNVCSVSGADK FT FLNHVNRYLSGRVMKRRIYAVIEACDGGSLSLNANLGCFTSPLLVTEYKMVQSHSSSLY FT RKAINNSLKQVNSYAPEHSDDLLSM" FT RBS 96996..96999 FT /note="possible RBS" FT CDS 97008..97943 FT /transl_table=11 FT /gene="HCM1.122" FT /product="hypothetical protein" FT /note="HCM1.122, hypothetical protein, len: 311 aa; unknown FT function. Similar to HCM1.123, hypothetical protein (318 FT aa), fasta scores; E(): 4.3e-28, 27.6% identity in 312 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q935N1" FT /protein_id="CAD09720.1" FT /translation="MFNESDDKNFVSAMLKCQLGLNISQEDITIYDKENHFEQLSFKAN FT VALDDLLFYLDLYISELIKHNAPYSETEVLRTKIKYFLKVYEKSGFQNIRIRGYHNAHS FT TIDIVDIASLILAGSVPESEHDSIDPVLRKEIYQNRMSVEGKVLIARFALKQFFHSDFG FT DFILEFEKSISKCLNTSLQIIKSVKNSFNRLGQYQYQRRVKDDLTLHLDLNTDEYPACM FT PDLYIGFKESEGTTGVYRDDEKIIRLYTGVSSGKDVPVMMTVRFTGCDGSVLSESSHGT FT FCSVGPTGRVQVCDRVALVQEAVEELRDVV" FT RBS 98108..98111 FT /note="possible RBS" FT CDS 98120..99076 FT /transl_table=11 FT /gene="HCM1.123" FT /product="hypothetical protein" FT /note="HCM1.123, hypothetical protein, len: 318 aa; unknown FT function. Similar to HCM1.122, hypothetical protein (311 FT aa), fasta scores; E(): 2.7e-30, 27.6% identity in 312 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q935N0" FT /protein_id="CAD09721.1" FT /translation="MTNSTDNQNYVRAVLAGIGIDFDETEMFISVSHCQSDEVSFTCSI FT SASELRESAGHYVDTLNDTQLAGLDADALKKRLVYFLEVFDLVSGQYLDISGKHFATSR FT FEYDDVCSEILSNSADSAQPGGYDREEYKRLMEVDGQVLIARFALEKFWDTHFIGLINY FT VSDEITSGLYEVYRTFSDINMAGYTFSEYSYTRRITDELSLHISLKEDDFEEQLTDCYM FT DETTLPSGKVVLRRNNESIIGIYEGYASKSYFPMVANVRVLDTDGEVVTELYQGVNVSE FT LAGGRIKIHDRQELISEVFANLREFIPASEDKIFDAA" FT RBS 99478..99483 FT /note="possible RBS" FT CDS 99489..99758 FT /transl_table=11 FT /gene="HCM1.124" FT /product="hypothetical protein" FT /note="HCM1.124, hypothetical protein, len: 89 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5F2" FT /protein_id="CAD09722.1" FT /translation="MPATTILSNNPVNSVFSNDNSHFTYRHIDFSIELLLSSGTDSQLE FT YLFLKPAAEVKIDLQRRLASGERYVTTESCDNFSEVDGCMGHDC" FT CDS 99813..100403 FT /transl_table=11 FT /gene="HCM1.125" FT /product="putative membrane protein" FT /note="HCM1.125, possible membrane protein, len: 196 aa; FT unknown function, contains hydrophobic, possible FT membrane-spanning regions" FT /db_xref="UniProtKB/TrEMBL:Q935M9" FT /protein_id="CAD09723.1" FT /translation="MMTESFFDWVVYCITGVILASAFLEGKRTRFPAAFFYGSIVLLVV FT LIVAGALNWWFYRSKFGSVVVIFAATTLLMTRFRLVIYAFRFRTLVADLQSHVAKGFRI FT ILVLPENEDEKTVLLSKLSKVIHSGTLFYTRTALGPYSGDLLHALGQKHRNGEGYLLLC FT EQQLPARTWLSTVENGQPEKSIAVNFHSIPDME" FT RBS 100397..100400 FT /note="possible RBS" FT CDS 100411..100668 FT /transl_table=11 FT /gene="HCM1.126" FT /product="hypothetical protein" FT /note="HCM1.126, hypothetical protein, len: 85 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5F4" FT /protein_id="CAD09724.1" FT /translation="MSNTDSQTVPADALCENSSQVKIQLSRSASRALTTAKEILETRGL FT VSVSTEDLVQACLEENQPLDLASIYLEHRLKQKGTSICEF" FT CDS 100742..101278 FT /transl_table=11 FT /gene="HCM1.127" FT /product="hypothetical protein" FT /note="HCM1.127, hypothetical protein, len: 178 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5F5" FT /protein_id="CAD09725.1" FT /translation="MKSKIHSSGTSGTKRVLKTDIALPLLCWVFTSPFSNWTDKFFTGT FT EVPEGSLPGLEQAPEAIFRFVLNDEGFDVGFDAVGMDLCCFSIPLSTMPTKNLDDEETL FT SRLTGDVIHGVLLSLPEYIEMPDRLVYQLTDEVMAFNSHCGNGILHGWTTAQELWRNEI FT LPRTTILMQQTSVIH" FT CDS 101295..101750 FT /transl_table=11 FT /gene="HCM1.128" FT /product="putative membrane protein" FT /note="HCM1.128, possible membrane protein, len: 151 aa; FT unknown function, contains hydrophobic, possible FT membrane-spanning regions" FT /db_xref="UniProtKB/TrEMBL:Q935M8" FT /protein_id="CAD09726.1" FT /translation="MKKRLYLLEWKLRETRAWLGWMVFWIIISFMFLSAMFMTGHLLNK FT VVLQPVWLCIWSLPWLGFLLKVRVTEMDKGLVNTLQLGDLPVFRWSRSVVPGTWSVDRI FT NGRYRLNRIGTDGLTVHYPWRLYYQPLFLTPDKQISDINGREHERKF" FT CDS 101965..102243 FT /transl_table=11 FT /gene="HCM1.130" FT /product="hypothetical protein" FT /note="HCM1.130, hypothetical protein, len: 92 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935M7" FT /protein_id="CAD09727.1" FT /translation="MMHLLVEGKGVIPDVSVSDLGNVQNIRNELIGLGWWVKFGVKQDW FT QRINLQRQPVSFGLLNDLNRCFRHDGQQVEPLPLYTTGNPGELRKVL" FT RBS 102322..102325 FT /note="possible RBS" FT CDS 102332..103291 FT /transl_table=11 FT /gene="HCM1.131" FT /product="putative DNA replication terminus site-binding FT protein" FT /note="HCM1.131, possible DNA replication terminus FT site-binding protein, len: 319 aa; shows weak similarity to FT TUS proteins from the Enterobacteriaceae e.g. SW:TUS_ECOLI FT (EMBL:D90037), tus, Escherichia coli DNA replication FT terminus site-binding protein (309 aa), fasta scores; E(): FT 0.01, 25.5% identity in 208 aa overlap and SW:TUS_SALTY FT (EMBL:AF045242), tus, Salmonella typhimurium DNA FT replication terminus site-binding protein (309 aa), fasta FT scores; E(): 0.012, 25.6% identity in 203 aa overlap" FT /db_xref="GOA:Q9L5F9" FT /db_xref="InterPro:IPR008865" FT /db_xref="UniProtKB/TrEMBL:Q9L5F9" FT /protein_id="CAD09728.1" FT /translation="MASEDLLFYRDRILERIEKLRSFLNDHQPVMAELMTVGTVTRHEE FT RLKEVNPIEVSTISDASVDEIIRVIQDFCIDDIDVLSRNSTKVTTKYPGLIIVPEGAEQ FT LSGIICDINDAKSDFASAMKRVNSEKHIRFKEVHRKLPGLVTAHSTRKILFVEEQLKKV FT TFAWRLNRNQVKTNASDLIAMLDKRRLVAVKSPVTTDLTVVANIDRAKALLERKVLRDG FT EGYRLCRTNTFPVPIAHLFTYRPEGKERGSSKYAETDYKVVKASLPIFGVGQKPTIKRL FT QDWVPAQDEALSNGRRSNHSYTELVPGADLGIFIMRKV" FT RBS 103291..103295 FT /note="possible RBS" FT CDS 103302..104210 FT /transl_table=11 FT /gene="HCM1.132" FT /product="hypothetical protein" FT /note="HCM1.132, hypothetical protein, len: 302 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5G0" FT /protein_id="CAD09729.1" FT /translation="MQWISTTSQKLDERLYRVCVWVKKYHEDAINRVVLTVDLSKARHD FT PIEDQVRAELLCGHYFLMRKENNAKSAPADQNFEFLPDGRNLSWQTSTPGLQHLLLNSN FT VPESLRPLADYIQMRLAKLTMVPMSGTIMKAALEDSISWVKVDLRYYWQYELVNSHLGP FT VQVTHKALVRFGRLAKHDENASAIRMLRQRLSSPFIQEFEMPGEELKRKQKIMNTVDVK FT MLFHTHYPGQKLLLARYANGWVLVDCFLFHHIKPKKKAKNKTKAGKSETQNIKSTGSED FT HGTGHYGVHRVVTLTGSGVDQ" FT RBS 104139..104142 FT /note="possible RBS" FT CDS 104146..104490 FT /transl_table=11 FT /gene="HCM1.133" FT /product="putative membrane protein" FT /note="HCM1.133, possible membrane protein, len: 114 aa; FT unknown function, contains hydrophobic, possible FT membrane-spanning regions" FT /db_xref="UniProtKB/TrEMBL:Q9L5G1" FT /protein_id="CAD09730.1" FT /translation="MELGIMVCIVLLLSLAAVWISNKTVGLLEIHYFKRPLSMEYAAWL FT RVMCAGLLFIFIQMVPAFTFLYTLKLVALLNLGVQTMKLNGVYKFKRTGMMPPKDAPHD FT LGRFNPFRKK" FT CDS complement(104515..105696) FT /transl_table=11 FT /gene="HCM1.134c" FT /product="putative recombinase" FT /note="HCM1.134c, possible recombinase, len: 393 aa; shows FT weak similarity to SW:RECR_BPP1 (EMBL:X03453), cre, FT bacteriophage P1 recombinase (343 aa), fasta scores; E(): FT 2.7e-05, 25.9% identity in 352 aa overlap. The 4 active FT site residues identified in cre appear to be conserved. FT Contains Pfam match to entry PF00589 Phage_integrase, FT 'Phage' integrase family" FT /db_xref="GOA:Q9L5G2" FT /db_xref="HSSP:2CRX" FT /db_xref="InterPro:IPR002104" FT /db_xref="InterPro:IPR010998" FT /db_xref="InterPro:IPR011010" FT /db_xref="InterPro:IPR013762" FT /db_xref="UniProtKB/TrEMBL:Q9L5G2" FT /protein_id="CAD09731.1" FT /translation="MNSKPVTRQFEDSDLHQELVTFEVPNNDLKELIFYFSHMKYNTAK FT TYLQWLRSWNEWYQANAGKEGNEAWPASSLPVTEPPLLAYLDYLQGSLSHSSIKGCLHA FT LNSIHRKALDRPGIITSKVKSILASLEQAEAREQKVTRQATPFLVSDLKALIKAHGTTQ FT SVRKLRDLCIIWTGFETLLRSAELRRIRMQDLVLNEQTGSFTLTVYRTKSTVSTLLTYH FT LTPHLTATLIRLMDMVKRDQQSHPKDYLFQAVNYQDSGYMPPGWGLRSKGNEINTLLKN FT HNMPYRPTRPPIGKNGKPIIVDDEGMLSKNTLLRAFEAFWDELHPQEAGTRCWTGHSVR FT VGGAIELANAGYTHLQIMEMGNWSNPEMVSRYIRNIDAGKKAMTKFMREALDE" FT misc_feature complement(104551..105276) FT /note="Pfam match to entry PF00589 Phage_integrase, 'Phage' FT integrase family, score 9.80, E-value 3.7e-05" FT CDS 105911..106123 FT /transl_table=11 FT /gene="HCM1.135" FT /product="putative regulatory protein" FT /note="HCM1.135, probable regulatory protein, len: 70 aa; FT similar to Hha/YmoA class of bacterial regulators e.g. FT SW:HHA_ECOLI (EMBL:X57977), hha, Escherichia coli FT haemolysin expression modulating protein (72 aa), fasta FT scores; E(): 2.6e-10, 48.6% identity in 72 aa overlap and FT SW:YMOA_YEREN (EMBL:X58058), ymoA, Yersinia enterocolitica FT gene modulating the expression of virulence functions (67 FT aa), fasta scores; E(): 1e-09, 50.7% identity in 67 aa FT overlap. Plasmid-borne homologue exists in Escherichia coli FT plasmid pO157 TR:Q9ZGV7 (EMBL:AF074613), L7004, Escherichia FT coli putative hemolysin expression modulating protein (69 FT aa), fasta scores; E(): 2.3e-08, 40.6% identity in 69 aa FT overlap and plasmid R100 TR:O32581 (EMBL:Y13856), rmoA, FT Escherichia coli RmoA protein (69 aa), fasta scores; E(): FT 2.7e-08, 40.6% identity in 69 aa overlap" FT /db_xref="HSSP:1JW2" FT /db_xref="InterPro:IPR007985" FT /db_xref="UniProtKB/TrEMBL:Q935M6" FT /protein_id="CAD09732.1" FT /translation="MSETKQAYLMKFRKCSSFDTLEKVFERLCEKNAGIASLEISGAYD FT HRKAELTMKKLYDKVPASVWTLVRQ" FT repeat_region 106385..106397 FT /note="13 bp inverted repeat flanking IS1" FT repeat_region 106385..107132 FT /note="IS1" FT CDS 106430..106705 FT /transl_table=11 FT /gene="insA" FT /gene_synonym="HCM1.136" FT /product="putative IS1 transposase" FT /note="HCM1.136, insA, probable IS1 transposase, highly FT similar to many e.g. SW:ISA1_ECOLI (EMBL:X52534), insA, FT Escherichia coli insertion element IS1 protein InsA (91 FT aa), fasta scores; E(): 0, 96.7% identity in 91 aa overlap. FT Contains PS00017 ATP/GTP-binding site motif A (P-loop). FT Contains a probable helix-turn-helix motif at aa 64-85 FT (Score 1364, +3.83 SD)" FT /db_xref="GOA:Q935M5" FT /db_xref="InterPro:IPR003220" FT /db_xref="UniProtKB/TrEMBL:Q935M5" FT /protein_id="CAD09733.1" FT /translation="MASVSISRPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY FT TASQPGTHQKIIDMAINGVGCRATARIMGVGLNTILRHLKNSGRSR" FT misc_feature 106475..106498 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 106624..107127 FT /transl_table=11 FT /gene="insB" FT /gene_synonym="HCM1.136a" FT /product="putative IS1 transposase" FT /note="HCM1.136a, insB, possible IS1 transposase, len: 167 FT aa; highly similar to many from Enterobacteriaceae e.g. FT SW:ISB_ECOLI (EMBL:D10483), insB, Escherichia coli FT insertion element IS1 protein InsB (167 aa), fasta scores; FT E(): 0, 98.8% identity in 167 aa overlap" FT /db_xref="GOA:Q935M4" FT /db_xref="InterPro:IPR005063" FT /db_xref="UniProtKB/TrEMBL:Q935M4" FT /protein_id="CAD09734.1" FT /translation="MPGNCPHYGRWPQHDFTSLKKLRPQSVTSRIQPGSDVIVCAEMDE FT QWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWP FT LYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNI FT KHYQ" FT misc_feature 106681..106686 FT /note="possible translational frameshift site, similar to FT that determined experimentally (EMBL:X52534)" FT repeat_region complement(107120..107132) FT /note="13 bp inverted repeat flanking IS1" FT misc_feature 107404..107616 FT /note="86% identity to F-plasmid origin of replication in FT EMBL:J01724" FT repeat_region 107518..107537 FT /note="similar to incB repeats; 86% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region 107539..107558 FT /note="similar to incB repeats; 98% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region 107572..107591 FT /note="similar to incB repeats; 91% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region 107594..107613 FT /note="similar to incB repeats; 93% identity to consensus FT CTGTGACAAATCACCCTCAA" FT CDS 107709..108464 FT /transl_table=11 FT /gene="rep" FT /gene_synonym="HCM1.137" FT /product="putative replication initiation protein" FT /note="HCM1.137, rep, probable replication initiation FT protein, len: 251 aa; similar to many e.g. SW:REPE_ECOLI FT (EMBL:J01724), rep, Escherichia coli rep protein from the F FT plasmid (251 aa), fasta scores; E(): 0, 94.8% identity in FT 249 aa overlap. Contains Pfam match to entry PF01051 FT RepB_protein, Initiator RepB protein" FT /db_xref="GOA:P62539" FT /db_xref="InterPro:IPR000525" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:P62539" FT /protein_id="CAD09735.1" FT /translation="MAEIAVINHKKRKNSPRIVQSNELTEAAYSLSRDQKRLLYLFVHQ FT IRKSDGSLQEHDGICEIHVAKYAETFGLTSAEASKDIRQALKGFAGKEVVFYRPEEDAG FT DEKGYESFPWFIKRAHSPSRGLYSVHINPYLIPFFIGLQNRFTQFRLSETKEITNPYAM FT RLYESLCQYRKPDGSGVVSLKIDWIMERYQLPQSYQRMPDFRRRFLKASVDEINSRTPM FT RLSYIEKKKGRQTTHIVFSFRDITSMTIE" FT misc_feature 108300..108428 FT /note="Pfam match to entry PF01051 RepB_protein, Initiator FT RepB protein, score 21.30, E-value 2.5e-05" FT repeat_region complement(108465..108484) FT /note="similar to incB repeats; 90% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region complement(108487..108506) FT /note="similar to incB repeats; 94% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region complement(108520..108539) FT /note="similar to incB repeats; 90% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region complement(108542..108561) FT /note="similar to incB repeats; 94% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region complement(108575..108594) FT /note="similar to incB repeats; 100% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region complement(108597..108616) FT /note="similar to incB repeats; 94% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region complement(108630..108649) FT /note="similar to incB repeats; 100% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region complement(108722..108741) FT /note="similar to incB repeats; 86% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region complement(108746..108765) FT /note="similar to incB repeats; 93% identity to consensus FT CTGTGACAAATCACCCTCAA" FT repeat_region 108797..108809 FT /note="13 bp inverted repeat flanking IS1" FT misc_feature 108797..109544 FT /note="IS1" FT CDS 108842..109117 FT /transl_table=11 FT /gene="insA" FT /gene_synonym="HCM1.138" FT /product="putative IS1 transposase" FT /note="HCM1.138, insA, probable IS1 transposase, len: 91 FT aa; highly similar to many e.g. SW:ISA1_ECOLI FT (EMBL:X52534), insA, Escherichia coli insertion element IS1 FT protein InsA (91 aa), fasta scores; E(): 0, 97.8% identity FT in 91 aa overlap. Contains PS00017 ATP/GTP-binding site FT motif A (P-loop). Contains a probable helix-turn-helix FT motif at aa 64-85 (Score 1462, +4.17 SD)" FT /db_xref="GOA:Q7AQV4" FT /db_xref="InterPro:IPR003220" FT /db_xref="UniProtKB/TrEMBL:Q7AQV4" FT /protein_id="CAD09736.1" FT /translation="MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY FT TASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHLKNSGRSR" FT misc_feature 108887..108910 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 109036..109539 FT /transl_table=11 FT /gene="insB" FT /gene_synonym="HCM1.136a" FT /product="putative IS1 transposase" FT /note="HCM1.139, insB, possible IS1 transposase, len: 167 FT aa; highly similar to many from Enterobacteriaceae e.g. FT SW:ISB_ECOLI (EMBL:D10483), insB, Escherichia coli FT insertion element IS1 protein InsB (167 aa), fasta scores; FT E(): 0, 89.8% identity in 167 aa overlap" FT /db_xref="GOA:Q935M3" FT /db_xref="InterPro:IPR005063" FT /db_xref="UniProtKB/TrEMBL:Q935M3" FT /protein_id="CAD09737.1" FT /translation="MPGNRPHYGRWPQHDFPPFKKLRPQSVTSRIQPGSDVIVCAEMDE FT QWGYVGAKSRQLWLFYAYDRIRRTVVAHVFGERTLATLERLPGLLSAFEVVVWMTDDWP FT LYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLTI FT KHYQ" FT misc_feature 109093..109098 FT /note="possible translational frameshift site, similar to FT that determined experimentally (EMBL:X52534)" FT repeat_region complement(109532..109544) FT /note="13 bp inverted repeat flanking IS1" FT CDS 109949..111022 FT /transl_table=11 FT /gene="HCM1.141" FT /product="hypothetical protein" FT /note="HCM1.141, hypothetical protein, len: 357 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5G8" FT /protein_id="CAD09738.1" FT /translation="MRKSYTYGIPFGLHRETGRFLDITEVSRGSACNCICPGCRTDLIA FT RQGEVKLWHYSHSTDLLGDCDGLMEAIRGKIIEIIQEKQLLGFPHLLAGYDGGTVPLDE FT VSGSGSMFGATADLFVKVNDLCVAVFLDIDRSVAGKLTFDHLHASEMVAALRIDLPDIE FT YEISQVQLGRRDGTYSECIEKIIIDATESREWLYHPMMQELGTEPLKVYEGREPAEAGP FT LLQRLSDCPLKLPDNLPQSMNVLIRMQQATIVCLCRLTVRASDIAQTDEFPLFMRYFRL FT HCLDTSEHVNYEKLLNWQDMITKSKEGQLLTVEERDYLQEIVRIGLYNHRLKSVCLTAC FT EDSRVGESEGPNNYSLL" FT CDS complement(111100..111243) FT /transl_table=11 FT /gene="HCM1.141ac" FT /product="hypothetical protein" FT /note="HCM1.141ac, hypothetical protein, len: 47 aa; FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q935M2" FT /protein_id="CAD09739.1" FT /translation="MRPLALSEDGLIQDAFTKEEPLGLVLMAVPIYITGLIMIGTLFTC FT KK" FT CDS complement(111279..111767) FT /transl_table=11 FT /gene="HCM1.142c" FT /product="hypothetical protein" FT /note="HCM1.142c, hypothetical protein, len: 162 aa; FT similar to TR:Q9Z4G2 (EMBL:AB021078), yadA, Escherichia FT coli hypothetical protein from plasmid IncI1 ColIb-P9 (149 FT aa), fasta scores; E(): 1.2e-28, 54.9% identity in 142 aa FT overlap" FT /db_xref="UniProtKB/TrEMBL:Q935M1" FT /protein_id="CAD09740.1" FT /translation="MVSPMEKTQSPAERFYESIYYSDESLEEDYLAELRNFSSDHWDTA FT LRAARLSAAVKRFKTSEMLRFILEFVVPENAQEDAPDLTPLAAKRLCNSLFGRSGSQSI FT LVYVFGQAGRVHRSATCSPKTIEAIAALYRSDAERYWNSTLATIERVKHTYRAKIRNS" FT CDS 111903..112178 FT /transl_table=11 FT /gene="HCM1.143" FT /product="hypothetical protein" FT /note="HCM1.143, hypothetical protein, len: 91 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935M0" FT /protein_id="CAD09741.1" FT /translation="MSVKCLPLQSGLDEKDQGLFQNGRNTRNVEENVALNNMIAIFKKV FT GVTHYVYSIYHFQIVIKIRLPERQKQKKSIKQKCMVSILPPATLAP" FT CDS 112168..112368 FT /transl_table=11 FT /gene="HCM1.144" FT /product="hypothetical protein" FT /note="HCM1.144, hypothetical protein, len: 66 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935L9" FT /protein_id="CAD09742.1" FT /translation="MRPDNFILGEGALIITYPIRKAGNQNVTRISKMQRFNISVFSVSW FT QQSRSAGTGKLYSTSPGLAGD" FT RBS 112424..112429 FT /note="possible RBS" FT CDS 112435..112827 FT /transl_table=11 FT /gene="HCM1.145" FT /product="hypothetical protein" FT /note="HCM1.145, hypothetical protein, len: 130 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935L8" FT /protein_id="CAD09743.1" FT /translation="MDDKEQFTSLVAKHASRFTEEQLAGYDACSQYGECVSPSYEVFRG FT YRTRHTLDEFLELAISLNAIHPDEYLTDMLLKPHEVIGALADEGDQLNNATPVYFFPDT FT GVYAAAVSETRVLDAWLCWPCYPANW" FT repeat_region 112896..112912 FT /note="inverted repeat; 17/17 (100%) matches, 0 gaps" FT repeat_region complement(113131..113147) FT /note="inverted repeat; 17/17 (100%) matches, 0 gaps" FT CDS 113240..113443 FT /transl_table=11 FT /gene="HCM1.146" FT /product="hypothetical protein" FT /note="HCM1.146, hypothetical protein, len: 67 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935L7" FT /protein_id="CAD09744.1" FT /translation="MFSTEKKSEHLGQIIVIDPALLGQGIEVGPVVVFDLGHASKGVAD FT LMRDAEKLDGLSPTTIANRLSR" FT RBS 113587..113590 FT /note="possible RBS" FT CDS 113598..114524 FT /transl_table=11 FT /gene="HCM1.149" FT /product="hypothetical protein" FT /note="HCM1.149, hypothetical protein, len: 308 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935L6" FT /protein_id="CAD09745.1" FT /translation="MRSEIPSGRFFCLDEFHNFHMSDDVLRERLRSIDGIPAVSYQVNG FT ENVFVFEKLVQLVKQNGHNLESALALVPKATMTAAEAIEAWSVFPEPYSRETNTIDHSQ FT AIYHPYLNAYLPRKYPDRESCNADAARLLLGNPVEGEGDFVYRGQSMVLRQPFTLDRLP FT PRPEWDVPVSEDASAYTHLWNTDFVSGFAPVTESLFNGIKSAEWEWNHAIAATYAYMGN FT PECISSLWSRAGEFGLEQLELKSWDVDEQDPEHYQQFQALYPELSMLSPAIIQKAYDEY FT CESMWENPERCDGFLYHLIGVVSEFGK" FT CDS complement(114531..114986) FT /transl_table=11 FT /gene="merR" FT /gene_synonym="HCM1.151c" FT /product="putative mercuric resistance operon regulatory FT protein" FT /note="HCM1.151c, merR, probable mercuric resistance operon FT regulatory protein, len: 151 aa; highly similar to many FT e.g. SW:MERR_PSEAE (EMBL:Z00027), merR, Pseudomonas FT aeruginosa mercuric resistance operon regulatory protein FT from plasmid pVS1 (144 aa), fasta scores; E(): 0, 92.3% FT identity in 142 aa overlap. Contains Pfam match to entry FT PF00376 merR, Bacterial regulatory proteins, merR family FT and PS00552 Bacterial regulatory proteins, merR family FT signature. Contains a probable helix-turn-helix motif at aa FT 8-29 (Score 1571, +4.54 SD). Similar to HCM1.245, merR, FT probable mercuric resistance operon regulatory protein (144 FT aa), fasta scores; E(): 0, 89.4% identity in 142 aa FT overlap" FT /db_xref="GOA:Q935L5" FT /db_xref="HSSP:1Q0A" FT /db_xref="InterPro:IPR000551" FT /db_xref="InterPro:IPR009061" FT /db_xref="InterPro:IPR011794" FT /db_xref="InterPro:IPR015358" FT /db_xref="UniProtKB/TrEMBL:Q935L5" FT /protein_id="CAD09746.1" FT /translation="MQINFENLTIGVFAKAAGVNVETIRFYQRKGLLPEPDKPYGSIRR FT YGEADVTRVRFVKSAQRLGFSLDEIAELLRLEDGTHCEEASGLAEHKLKDVREKMADLA FT RMEAVLSELVCACHARKGNVFCPLIASLQDGTKLAASARGSHGVTTP" FT misc_feature complement(114849..114956) FT /note="Pfam match to entry PF00376 merR, Bacterial FT regulatory proteins, merR family, score 66.90, E-value FT 4.2e-16" FT misc_feature complement(114888..114956) FT /note="PS00552 Bacterial regulatory proteins, merR family FT signature" FT misc_feature complement(114900..114956) FT /note="Pfam match to entry PF00376 merR, Bacterial FT regulatory proteins, merR family, score 29.10, E-value FT 7.8e-05" FT RBS complement(114996..114999) FT /note="possible RBS" FT RBS 115046..115050 FT /note="possible RBS" FT CDS 115058..115423 FT /transl_table=11 FT /gene="merT" FT /gene_synonym="HCM1.152" FT /product="putative mercuric transport protein" FT /note="HCM1.152, merT, probable mercuric transport protein, FT len: 121 aa; highly similar to many e.g. SW:MERT_SERMA FT (EMBL:M24940), merT, Serratia marcescens mercuric transport FT protein from plasmid pDU1358 (116 aa), fasta scores; E(): FT 0,96.5% identity in 115 aa overlap. Contains hydrophobic, FT probable membrane-spanning regions. Similar to HCM1.234c, FT merT, probable mercuric transport protein (116 aa), fasta FT scores; E(): 0, 93.0% identity in 115 aa overlap" FT /db_xref="GOA:Q935L4" FT /db_xref="InterPro:IPR003457" FT /db_xref="UniProtKB/TrEMBL:Q935L4" FT /protein_id="CAD09747.1" FT /translation="MSEPQKSEPQNGRGALFAGGLAAILASACCLGPLVLIALGFSGAW FT IGNLTVLEPYRPIFIGAALVALFFAWRRIYRPAQACKPGEVCAIPQVRATYKLIFWIVA FT ALVLVSLGFPYVMPFFY" FT RBS 115428..115432 FT /note="possible RBS" FT CDS 115439..115714 FT /transl_table=11 FT /gene="merP" FT /gene_synonym="HCM1.153" FT /product="putative mercuric transport protein periplasmic FT binding protein" FT /note="HCM1.153, merP, probable mercuric transport protein FT periplasmic binding protein, len: 91 aa; highly similar to FT many e.g. SW:MERP_PSEAE (EMBL:Z00027), merP, Pseudomonas FT aeruginosa mercuric transport protein periplasmic component FT precursor from plasmid pVS1 (91 aa), fasta scores; E(): FT 2.5e-27, 84.4% identity in 90 aa overlap. Contains Pfam FT match to entry PF00403 HMA, Heavy-metal-associated domain FT and PS01047 Heavy-metal-associated domain. Contains a FT probable N-terminal signal sequence. Similar to HCM1.233c, FT merP, probable mercuric transport protein periplasmic FT binding protein (91 aa), fasta scores; E(): 6.4e-31, 82.4% FT identity in 91 aa overlap" FT /db_xref="GOA:P0A216" FT /db_xref="InterPro:IPR001757" FT /db_xref="InterPro:IPR001802" FT /db_xref="InterPro:IPR006121" FT /db_xref="InterPro:IPR011795" FT /db_xref="InterPro:IPR017969" FT /db_xref="UniProtKB/Swiss-Prot:P0A216" FT /protein_id="CAD09748.1" FT /translation="MKKLFAALALAAVVAPVWAATQTVTLSVPGMTCASCPITVKHALS FT KVEGVSKTDVSFDKRQAVVTFDDAKTNVQKLTKATEDAGYPSSLKR" FT misc_feature 115508..115705 FT /note="Pfam match to entry PF00403 HMA, FT Heavy-metal-associated domain, score 101.20, E-value FT 1.8e-27" FT misc_feature 115520..115609 FT /note="PS01047 Heavy-metal-associated domain" FT RBS 115732..115735 FT /note="possible RBS" FT CDS 115742..116167 FT /transl_table=11 FT /gene="merC" FT /gene_synonym="HCM1.157" FT /product="putative mercury transport protein" FT /note="HCM1.157, merC, probable mercury transport protein, FT len: 141 aa; highly similar to many e.g. TR:O66048 FT (EMBL:U90263), merC, Pseudomonas stutzeri MerC protein from FT plasmid pPB (141 aa), fasta scores; E(): 0, 80.1% identity FT in 141 aa overlap. Contains hydrophobic, probable FT membrane-spanning regions. Similar to HCM1.232c, merC, FT probable mercury transport protein (140 aa), fasta scores; FT E(): 0, 73.0% identity in 141 aa overlap" FT /db_xref="InterPro:IPR004891" FT /db_xref="UniProtKB/TrEMBL:Q7AQV2" FT /protein_id="CAD09749.1" FT /translation="MGLITRIAGKTGALGSVVSAMGCAACFPAIASFGAAIGLGFLSQY FT EGLFIGILLPMFAGIALLANAIAWLNHRQWRRTALGTIGPILVLAAVFLMRAYGWQSGG FT LLYVGLALMVGVSVWDFISPAHRRCGPDSCELPEQRG" FT RBS 116194..116198 FT /note="possible RBS" FT CDS 116206..117891 FT /transl_table=11 FT /gene="merA" FT /gene_synonym="HCM1.158" FT /product="putative mercuric reductase" FT /EC_number="1.16.1.1" FT /note="HCM1.158, merA, probable mercuric reductase, len: FT 561 aa; highly similar to many e.g. SW:MERA_PSEAE FT (EMBL:Z00027), merA, Pseudomonas aeruginosa mercuric FT reductase from plasmid pVS1 (EC 1.16.1.1) (561 aa), fasta FT scores; E(): 0, 93.0% identity in 561 aa overlap. Contains FT Pfam matches to entry PF00403 HMA, Heavy-metal-associated FT domain and to entry PF00070 pyr_redox, Pyridine FT nucleotide-disulphide oxidoreductase class-I. Contains FT PS01047 Heavy-metal-associated domain and PS00076 Pyridine FT nucleotide-disulphide oxidoreductases class-I active site. FT Similar to HCM1.231c, merA, probable mercuric reductase FT (564 aa), fasta scores; E(): 0, 85.0% identity in 565 aa FT overlap" FT /db_xref="GOA:Q935L3" FT /db_xref="HSSP:1AW0" FT /db_xref="InterPro:IPR000815" FT /db_xref="InterPro:IPR001327" FT /db_xref="InterPro:IPR004099" FT /db_xref="InterPro:IPR006121" FT /db_xref="InterPro:IPR011796" FT /db_xref="InterPro:IPR012999" FT /db_xref="InterPro:IPR013027" FT /db_xref="InterPro:IPR016156" FT /db_xref="InterPro:IPR017969" FT /db_xref="UniProtKB/TrEMBL:Q935L3" FT /protein_id="CAD09750.1" FT /translation="MTTLKITGMTCDSCAAHVKEALEKVPGVQSALVSYPKGTAQLAIE FT AGTSSDALTTAVAGLGYEATLADAPPTDNRAGLLDKMRGWIGAADKPSGNERPLQVVVI FT GSGGAAMAAALKAVEQGAQVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFD FT GGMPPTPPTILRERLLAQQQARVEELRHAKYEGILDGNSAITVLHGEARFKDDQSLIVS FT LNEGGERVVMFDRCLVATGASPAVPPIPGLKESPYWTSTEALASDTIPERLAVIGSSVV FT ALELAQAFARLGSKVTALARNTLFFREDPAIGEAVTAAFRAEGIEVLEHTQASQVAHMD FT GEFVLTTTHGELRADKLLVATGRTPNTRSLALEAAGVAVNAQGAIVIDKGMRTSSPNIY FT AAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVVFTDPQVATVGYSEAEAH FT HDGIETDSRLLTLDNVPRALANFDTRGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAVL FT AIRNRMTVQELADQLFPYLTMVEGLKLAAQTFSKDVKQLSCCAG" FT misc_feature 116209..116403 FT /note="Pfam match to entry PF00403 HMA, FT Heavy-metal-associated domain, score 90.10, E-value FT 2.8e-24" FT misc_feature 116221..116310 FT /note="PS01047 Heavy-metal-associated domain" FT misc_feature 116506..117870 FT /note="Pfam match to entry PF00070 pyr_redox, Pyridine FT nucleotide-disulphide oxidoreductase class-I, score 757.30, FT E-value 6.3e-224" FT misc_feature 116602..116634 FT /note="PS00076 Pyridine nucleotide-disulphide FT oxidoreductases class-I active site" FT RBS 117896..117903 FT /note="possible RBS" FT CDS 117909..118274 FT /transl_table=11 FT /gene="merD" FT /gene_synonym="HCM1.159" FT /product="putative mercuric resistance operon coregulator" FT /note="HCM1.159, merD, probable mercuric resistance operon FT coregulator, len: 121 aa; highly similar to many e.g. FT SW:MERD_PSEA (EMBL:Z00027), merD, Pseudomonas aeruginosa FT mercuric resistance protein from plasmid pVS1 (121 aa), FT fasta scores; E(): 0, 88.4% identity in 121 aa overlap. FT Similar to HCM1.230c, merD, probable mercuric resistance FT operon coregulator (120 aa), fasta scores; E(): 0, 82.6% FT identity in 121 aa overlap" FT /db_xref="GOA:P0A2Q6" FT /db_xref="InterPro:IPR000551" FT /db_xref="InterPro:IPR009061" FT /db_xref="InterPro:IPR011797" FT /db_xref="UniProtKB/Swiss-Prot:P0A2Q6" FT /protein_id="CAD09751.1" FT /translation="MSAYTVSRLALDAGVSVHIVRDYLLRGLLRPVAYTTGGYGLFDDT FT ALQRLRFVRAAFEAGIGLDALARLCRALDAADGDGASAQLAVLRQLVERRREALASLEM FT QLAAMPTEPAQHAESLP" FT RBS 118259..118262 FT /note="possible RBS" FT CDS 118271..118507 FT /transl_table=11 FT /gene="HCM1.160" FT /product="hypothetical protein" FT /note="HCM1.160, hypothetical protein, len: 78 aa; highly FT similar to ORFs from transposable elements containing FT mer-operons e.g. TR:Q52111 (EMBL:L04303), urf1, FT Acinetobacter calcoaceticus unassigned open reading frame FT from plasmid pKLH2 (78 aa), fasta scores; E(): 6.4e-32, FT 98.7% identity in 78 aa overlap" FT /db_xref="InterPro:IPR007746" FT /db_xref="UniProtKB/TrEMBL:Q935L2" FT /protein_id="CAD09752.1" FT /translation="MNSPEHLPSETHKPITGYLWGALAVLTCPCYLPILAIVLAGTTAG FT AFIGEHWGIAALTLTGLFVLSVTRLLRAFKGRS" FT RBS 118561..118565 FT /note="possible RBS" FT CDS 118573..118785 FT /transl_table=11 FT /gene="HCM1.161" FT /product="hypothetical protein" FT /note="HCM1.161, hypothetical protein, len: 70 aa; similar FT to part of SW:TNPM_ECOLI (EMBL:M10791), tnpM, Escherichia FT coli transposon Tn21 modulator protein (116 aa), fasta FT scores; E(): 8.8e-19, 71.0% identity in 69 aa overlap and FT to hypothetical proteins from many transposable elements" FT /db_xref="UniProtKB/TrEMBL:Q7AQV1" FT /protein_id="CAD09753.1" FT /translation="MNANAPNTASCTTCCVCCKEIPLDAAFTPEGAEYVEHFCGLDCYE FT RFQARAKAATESDIAPVPGGSQPSD" FT repeat_region 118817..118939 FT /note="123 bp inverted repeat flanking IS6100" FT repeat_region complement(118817..119971) FT /note="IS6100" FT CDS complement(119023..119787) FT /transl_table=11 FT /gene="HCM1.162c" FT /product="putative transposase" FT /note="HCM1.162c, probable transposase, len: 254 aa; FT identical to TR:Q49185 (EMBL:X53635), tnp, Mycobacterium FT fortuitum Tn610 transposase (254 aa), fasta scores; E(): 0, FT 100.0% identity in 254 aa overlap. Highly similar to many FT other transposases. Contains Pfam match to entry PF01438 FT Transposase_3, Transposase" FT /db_xref="GOA:Q7AQV0" FT /db_xref="InterPro:IPR001584" FT /db_xref="UniProtKB/TrEMBL:Q7AQV0" FT /protein_id="CAD09754.1" FT /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDHT FT TIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTIDFY FT LSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETAHRQ FT VKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQPGIR FT GEVRLVERAFGIGPSALTEAMGMLNHHFAAAA" FT misc_feature complement(119188..119787) FT /note="Pfam match to entry PF01438 Transposase_3, FT Transposase, score 502.60, E-value 2.9e-147" FT repeat_region complement(119849..119971) FT /note="123 bp inverted repeat flanking IS6100" FT CDS 119966..120250 FT /transl_table=11 FT /gene="HCM1.163" FT /product="hypothetical protein" FT /note="HCM1.163, hypothetical protein, len: 94 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935L1" FT /protein_id="CAD09755.1" FT /translation="MTIVPPAPGLIEQLRHMVQMLVDPFGQFFDGLLLELVTFPELDVQ FT GPGHLVEVPADSSKLPARFPYGVHFFISEDRHPVQRPQSFLYLNSPANM" FT CDS complement(120417..120899) FT /transl_table=11 FT /gene="dhfR" FT /gene_synonym="HCM1.165c" FT /product="putative dihydrofolate reductase" FT /EC_number="1.5.1.3" FT /note="HCM1.165c, dhfR, probable dihydrofolate reductase, FT len: 160 aa; highly similar to many e.g. SW:DYR5_ECOLI FT (EMBL:X12868), dhfRV, Escherichia coli dihydrofolate FT reductase type V (EC 1.5.1.3) (157 aa), fasta scores; E(): FT 0, 89.8% identity in 157 aa overlap. Contains Pfam match to FT entry PF00186 DiHfolate_red, Dihydrofolate reductase and FT PS00075 Dihydrofolate reductase signature" FT /db_xref="GOA:Q935L0" FT /db_xref="HSSP:1DHI" FT /db_xref="InterPro:IPR001796" FT /db_xref="InterPro:IPR012259" FT /db_xref="InterPro:IPR017925" FT /db_xref="UniProtKB/TrEMBL:Q935L0" FT /protein_id="CAD09756.1" FT /translation="MRTLKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLL FT VGRKTFESMGALPNRKYAVVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGE FT IYRETLPMASTLHLSTIDIEPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG" FT misc_feature complement(120504..120881) FT /note="Pfam match to entry PF00186 DiHfolate_red, FT Dihydrofolate reductase, score 136.60, E-value 9.8e-39" FT misc_feature complement(120783..120851) FT /note="PS00075 Dihydrofolate reductase signature" FT CDS complement(<120907..120963) FT /transl_table=11 FT /gene="HCM1.166c" FT /product="putative aminoglycoside acetyltransferase" FT /note="HCM1.166c, possible aminoglycoside FT acetyltransferase, partial CDS, len: 19 aa; highly similar FT to the N-termini of aminoglycoside 3' N-acetyltransferases FT e.g. SW:AAC1_PSEAE (EMBL:U12338), aacC1, Pseudomonas FT aeruginosa gentamicin 3'-acetyltransferase from plasmid FT R1033 (177 aa), fasta scores; E(): 1.4e-07, 94.7% identity FT in 19 aa overlap" FT /db_xref="GOA:Q935K9" FT /db_xref="UniProtKB/TrEMBL:Q935K9" FT /protein_id="CAD09757.1" FT /translation="MLWSSNDVTQQGSRPKTKL" FT CDS 121046..122059 FT /transl_table=11 FT /gene="int" FT /gene_synonym="HCM1.167" FT /product="putative integrase" FT /note="HCM1.167, int, probable integrase, len: 337 aa; FT identical to SW:INT2_ECOLI (EMBL:U12338), int, Escherichia FT coli integrase/recombinase (E2 protein) from plasmid pLM020 FT (337 aa), fasta scores; E(): 0, 100.0% identity in 337 aa FT overlap. Highly similar to many others. Contains Pfam match FT to entry PF00589 Phage_integrase, 'Phage' integrase family" FT /db_xref="GOA:P62592" FT /db_xref="InterPro:IPR002104" FT /db_xref="InterPro:IPR004107" FT /db_xref="InterPro:IPR010998" FT /db_xref="InterPro:IPR011010" FT /db_xref="InterPro:IPR011946" FT /db_xref="InterPro:IPR013762" FT /db_xref="UniProtKB/Swiss-Prot:P62592" FT /protein_id="CAD09758.1" FT /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVHWVRAFI FT RFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQEI FT GRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDFDHG FT TIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALERKYPR FT AGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATPHTLRH FT SFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLTSER" FT misc_feature 121313..122011 FT /note="Pfam match to entry PF00589 Phage_integrase, 'Phage' FT integrase family, score 201.70, E-value 1.1e-56" FT RBS 122356..122359 FT /note="possible RBS" FT CDS 122365..122922 FT /transl_table=11 FT /gene="tnpR" FT /gene_synonym="HCM1.168" FT /product="resolvase" FT /note="HCM1.168, tnpR, resolvase, len: 185 aa; highly FT similar to many e.g. SW:TNP2_ECOLI (EMBL:X01298), tnpR, FT Escherichia coli transposon Tn21 resolvase (186 aa), fasta FT scores; E(): 0, 82.7% identity in 185 aa overlap. Contains FT Pfam match to entry PF00239 recombinase, Site-specific FT recombinases, PS00397 Site-specific recombinases active FT site and PS00398 Site-specific recombinases signature 2. FT Contains a probable helix-turn-helix motif at aa 162-183 FT (Score 1545, +4.45 SD)" FT /db_xref="GOA:Q7AQU9" FT /db_xref="InterPro:IPR006118" FT /db_xref="InterPro:IPR006119" FT /db_xref="InterPro:IPR006120" FT /db_xref="InterPro:IPR009057" FT /db_xref="UniProtKB/TrEMBL:Q7AQU9" FT /protein_id="CAD09759.1" FT /translation="MQGQRIGYVRVSSFDQNPERQLEGVQVARVFTDKASGKDTQRPEL FT ERLLAFVREGDTVVVHSMDRLARNLDDLRRIVQGLTQRGVRMEFVKEGLKFTGEDSPMA FT NLMLSVMGAFAEFERALIRERQREGIVLAKQRGAYRGRKKSLNSEQIAELKRRVAAGDQ FT KTLVARDFGISRETLYQYLRED" FT misc_feature 122380..122904 FT /note="Pfam match to entry PF00239 recombinase, FT Site-specific recombinases, score 285.50, E-value 6.8e-82" FT misc_feature 122386..122412 FT /note="PS00397 Site-specific recombinases active site" FT misc_feature 122527..122565 FT /note="PS00398 Site-specific recombinases signature 2" FT misc_feature 122925..125828 FT /note="Pfam match to entry PF01526 Transposase_7, FT Transposase, score 2053.90, E-value 0" FT CDS 122925..125897 FT /transl_table=11 FT /gene="tnpA" FT /gene_synonym="HCM1.169" FT /product="transposase" FT /note="HCM1.169, tnpA, transposase, len: 990 aa; highly FT similar to many e.g. SW:TRA7_ECOLI (EMBL:X14236), tnpA, FT Escherichia coli transposase for transposon Tn3926 (990 FT aa), fasta scores; E(): 0, 99.9% identity in 990 aa FT overlap. Contains Pfam match to entry PF01526 FT Transposase_7, Transposase" FT /db_xref="GOA:Q7AQU8" FT /db_xref="InterPro:IPR002513" FT /db_xref="UniProtKB/TrEMBL:Q7AQU8" FT /protein_id="CAD09760.1" FT /translation="MPRRSILSATERESLLALPDAKDELIRHYTFNETDLSVIRQRRGA FT ANRLGFAVQLCYLRFPGTFLGVDEPPFPPLLRMVAAQLKMPVESWSEYGQREQTRREHL FT VELQTVFGFKPFTMSHYRQAVHTLTELALQTDKGIVLASALVENLRRQSIILPAMNAIE FT RASAEAITRANRRIYAALTDSLLSPHRQRLDELLKRKDGSKVTWLAWLRQSPAKPNSRH FT MLEHIERLKSWQALDLPAGIERQVHQNRLLKIAREGGQMTPADLAKFEVQRRYATLVAL FT AIEGMATVTDEIIDLHDRIIGKLFNAAKNKHQQQFQASGKAINDKVRMYGRIGQALIEA FT KQSGSDPFAAIEAVMPWDTFAASVTEAQTLARPADFDFLHHIGESYATLRRYAPQFLGV FT LKLRAAPAAKGVLDAIDMLRGMNSDSARKVPADAPTAFIKPRWAKLVLTDDGIDRRYYE FT LCALSELKNALRSGDVWVQGSRQFKDFDEYLVPVEKFATLKLASELPLAVATDCDQYLH FT DRLELLEAQLATVNRMAAANDLPDAIITTASGLKITPLDAAVPDAAQAMIDQTAMLLPH FT LKITELLMEVDEWTGFTRHFTHLKTSDTAKDKTLLLTTILADAINLGLTKMAESCPGTT FT YAKLSWLQAWHIRDETYSTALAELVNAQFRQPFAGNWGDGTTSSSDGQNFRTGSKAEST FT GHINPKYGSSPGRTFYTHISDQYAPFSAKVVNVGIRDSTYVLDGLLYHESDLRIEEHYT FT DTAGFTDHVFGLMHLLGFRFAPRIRDLGETKLFIPKGDAAYDALKPMISSDRLNIKQIR FT AHWDEILRLATSIKQGTVTASLMLRKLGSYPRQNGLAVALRELGRIERTLFILDWLQSV FT ELRRRVHAGLNKGEARNALARAVFFYRLGEIRDRSFEQQRYRASGLNLVTAAIVLWNTV FT YLERATSALRGNGTALDDTLLQYLSPLGWEHINLTGDYLWRSSAKVGAGKFRPLRPLPP FT A" FT repeat_region 125916..125927 FT /note="12 bp inverted repeat flanking IS" FT misc_feature 125916..127167 FT /note="IS" FT RBS 125965..125968 FT /note="possible RBS" FT CDS 125976..126915 FT /pseudo FT /transl_table=11 FT /gene="HCM1.170" FT /product="putative transposase (pseudogene)" FT /note="HCM1.170, probable transposase (pseudogene), len: ; FT highly similar to many e.g. SW:TRA8_YEREN (EMBL:Z48244), FT Yersinia enterocolitica transposase for insertion sequence FT element IS1328 (334 aa), fasta scores; E(): 7e-31, 69.2% FT identity in 104 aa overlap and E(): 0, 63.5% identity in FT 211 aa overlap" FT repeat_region complement(127156..127167) FT /note="12 bp inverted repeat flanking IS" FT CDS 127673..128164 FT /transl_table=11 FT /gene="HCM1.174" FT /product="putative periplasmic protein" FT /note="HCM1.174, possible periplasmic protein, len: 163 aa; FT unknown function, contains a probable N-terminal signal FT sequence" FT /db_xref="UniProtKB/TrEMBL:Q935K8" FT /protein_id="CAD09762.1" FT /translation="MKLTKMMATLFLLIPLTSFSQELGQRISQDDSAELANKAGTALTE FT MLLLKVQQLPQVKKNSGMDLAAANDAVASLLSKEFFIFKPVDEISIKTSAQKLKELNDD FT ADALAKGYTIIQPDDVGSSYISYKVTSSSRTCFIRLSKDLSSSLNTRIVTVNSMECSNP FT " FT RBS 128593..128596 FT /note="possible RBS" FT CDS 128603..129409 FT /transl_table=11 FT /gene="HCM1.175" FT /product="putative DNA-binding protein" FT /note="HCM1.175, possible DNA-binding protein, len: 268 aa; FT unknown function, contains PS00017 ATP/GTP-binding site FT motif A (P-loop). Contains a probable helix-turn-helix FT motif at aa 210-231 (Score 1104, +2.95 SD)" FT /db_xref="GOA:Q9L5H4" FT /db_xref="UniProtKB/TrEMBL:Q9L5H4" FT /protein_id="CAD09763.1" FT /translation="MREPRPRHTLQVVCVPSLNIQDLGLTSFHSWLLSKGYDTTNARNN FT RTCWAREGGWHLKRCRHLATGEDHFWFIAFNGTGGDIFPVKTQQDYRAAYRKLEAYGYA FT PAVIEQLNTGVAYNLAYSRTPLKRPESATSELKRKPDVNIQGEPCERFVTERSSAAQNK FT FKTLLIENFAGRCAVTGWVNGGVLVAAHIEHGTRYNPSNGILLTPTMHALFDADLMGID FT PSTLTVHFKPGIEAGELFEGKTLNPLVYDLDTDRLAARWADFIGAE" FT misc_feature 129311..129334 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 129515..129934 FT /transl_table=11 FT /gene="HCM1.176" FT /product="hypothetical protein" FT /note="HCM1.176, hypothetical protein, len: 139 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935K7" FT /protein_id="CAD09764.1" FT /translation="MIQQMQNCLSGYLKATIVILSAGLTGCDLANGTAESGVYQKYTNG FT PFKEPTIVMSPGWRMDDHGREALIFGSSHCPDVNGNNTSEGGCVLIEEHSATVAVTVVD FT ATNQSRRQETWTIERKKDRVIVKRPDNSFVMPWGK" FT CDS 129981..130691 FT /transl_table=11 FT /gene="HCM1.177" FT /product="hypothetical protein" FT /note="HCM1.177, hypothetical protein, len: 236 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935K6" FT /protein_id="CAD09765.1" FT /translation="MCVERPDGAFDIYTGRFIQFHQIDNSRRKIVEISDPDLVGMTYSI FT PMVFNGGKFSGQGVTCLSLPAVTLIKVTFPSRTYQEGQEQITMSSPDLALFSEDVRKNC FT AGTCVLTGVRGRQRTEAAHIKPRHAGGEPDVTNGILLRSDINTLFDNWHFSIDPDSMKA FT RFSPDVLSVDKDLLQLEGKQIDFSRLQMPINIEHLRHHWNKFFNRHVNPVIKNALNKKI FT NNYEKRPVSSNIHY" FT RBS 130750..130754 FT /note="possible RBS" FT CDS 130761..130943 FT /transl_table=11 FT /gene="HCM1.178" FT /product="hypothetical protein" FT /note="HCM1.178, hypothetical protein, len: 60 aa; FT hydrophobic protein" FT /db_xref="UniProtKB/TrEMBL:Q935K5" FT /protein_id="CAD09766.1" FT /translation="MNLKSIVPKAAGLAAWIVGIIYSGFALSVLWGGFCASRCGADHNS FT MGYWNLLLGRHNKRQ" FT repeat_region 130852..130859 FT /note="(g)8" FT CDS complement(131457..131861) FT /transl_table=11 FT /gene="HCM1.178ac" FT /product="putative DNA-binding protein" FT /note="HCM1.178ac, probable DNA-binding protein, len: 134 FT aa; similar to many histone-like proteins e.g. FT SW:STPA_ECOLI (EMBL:X69210), stpA, Escherichia coli FT DNA-binding protein (134 aa), fasta scores; E(): 4.7e-26, FT 61.9% identity in 134 aa overlap. Contains Pfam match to FT entry PF00816 Histone_HNS, H-NS histone family" FT /db_xref="GOA:Q935K4" FT /db_xref="HSSP:1NI8" FT /db_xref="InterPro:IPR001801" FT /db_xref="UniProtKB/TrEMBL:Q935K4" FT /protein_id="CAD09767.1" FT /translation="MSEALKSLNNIRTLRAQGRELPLEILEELLEKLSVVVEERRQEES FT SKEAELKARLEKIESLRQLMLEDGIDPEELLSSFSAKSGAPKKVREPRPAKYKYTDVNG FT ETKTWTGQGRTPKALAEQLEAGKTLDDFLI" FT misc_feature complement(131475..131861) FT /note="Pfam match to entry PF00816 Histone_HNS, H-NS FT histone family, score 222.70, E-value 5.3e-63" FT RBS complement(131866..131869) FT /note="possible RBS" FT CDS complement(132123..132395) FT /transl_table=11 FT /gene="HCM1.179c" FT /product="hypothetical protein" FT /note="HCM1.179c, hypothetical protein, len: 90 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935K3" FT /protein_id="CAD09768.1" FT /translation="MNRTDDSITQLSSLYERLGAVAHELEYCKILLPEHSEQLDLDAAA FT TYAMMLRIEQWAANVKNAYNTNTYDPFHINEKDKQLRNQEEENQY" FT CDS complement(132392..133060) FT /transl_table=11 FT /gene="HCM1.180c" FT /product="hypothetical protein" FT /note="HCM1.180c, hypothetical protein, len: 222 aa; FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q9L5I1" FT /protein_id="CAD09769.1" FT /translation="MAASRITHLITSCTKGKHSQCGSMPELSIRSGQTPEEAMSSWAAT FT IKRSQSASPVPALSLYAGNHWSTAKEILRTTENLELWVISAGLGFLNSRDLVDAYEATF FT HDLPFSHRQWWRELTNTFGKERTAKSIETLMAARPFDDYVIAASPVYIEATEDDILAGA FT SKLNNHIAQLTVVTSGEYSGLLESYLIRSESRMMRQLSSNMVCLNIKLAQYIIGSRRYS FT " FT repeat_region 133176..133199 FT /note="inverted repeat; 21/24 (87%) matches, 0 gaps" FT repeat_region complement(133454..133477) FT /note="inverted repeat; 21/24 (87%) matches, 0 gaps" FT RBS 133555..133559 FT /note="possible RBS" FT CDS 133567..134022 FT /transl_table=11 FT /gene="HCM1.181" FT /product="hypothetical protein" FT /note="HCM1.181 hypothetical protein, len: 151 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5I2" FT /protein_id="CAD09770.1" FT /translation="MSMNSQPELKLSTRTEQLASSRDAAMQKFLDGMTLIAEASAICGF FT SLFNSKIMAPNAFGLPASLAASIEEGRQQIDRKTWNNLFEETGIDRFWNHNQRAEFRES FT LRNAPPIASLTVIRSTLRQAVAMRSITLAEGFVDLLCQLDRRYKTNA" FT CDS 134029..134379 FT /transl_table=11 FT /gene="HCM1.182" FT /product="hypothetical protein" FT /note="HCM1.182 hypothetical protein, len: 116 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935K2" FT /protein_id="CAD09771.1" FT /translation="MMPKKLVLRGIFPDSNMMRYNGFSQDNLFYLNDFENVVCICSNAA FT TPPVGSGMNMYDRLAVLRKTDFTGDITDPKGWKFRLFGNGNVHISVECESLHNALNDLI FT SIYFANQIPAKG" FT RBS 134372..134376 FT /note="possible RBS" FT CDS 134382..135602 FT /transl_table=11 FT /gene="HCM1.183" FT /product="hypothetical protein" FT /note="HCM1.183, hypothetical protein, len: 406 aa; unknown FT function, rich in Ser, Thr, Glu and Gln" FT /db_xref="UniProtKB/TrEMBL:Q9L5I4" FT /protein_id="CAD09772.1" FT /translation="MMTDNVNLMNGDEQTASSLSEETSKTPPLSPELLKNSPYSSIAKV FT KYFTEIEQICLDKSISTENLDQFFKAHWLRDKMGGSFARAQEMLAAYKQYVDEVPEEAR FT AIEIPDQIKDAFSDFTAFITWYFRLSYTAIQSDSVKIAKAEITQLRQRNAEILEELSQS FT KEQATVLNNEKVNLINLLEQQRELSSKLEDSLQEAEETLAGTQSELQHAQNEIQLLQQT FT VGTLNQQLSERKQELASQQEYQKQLNDENKAQQVELTALKSQNDHLQRTVSDLKVSVSQ FT LEQDLSSVQTHSSELSSSLAEKDTTLTLVRSELSTAKGENDQLRAEAQRLADESLVAKK FT VQTDQTEELQQLRNQMISMEATLNAEKTIAESLRGTIKQLTEAMTGAVAIKPKSSGASK FT PRNKKTT" FT CDS complement(135657..135860) FT /transl_table=11 FT /gene="HCM1.184c" FT /product="hypothetical protein" FT /note="HCM1.184c, hypothetical protein, len: 67 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935K1" FT /protein_id="CAD09773.1" FT /translation="MAYILSMSEQVKLKAFLAAVLDDYKLGAISQQQAVGGITSLVDAI FT EISDSGKISLMLSEGRKLLRTG" FT CDS complement(135898..137193) FT /transl_table=11 FT /gene="HCM1.185c" FT /product="hypothetical protein" FT /note="HCM1.185c, hypothetical protein, len: 431 aa; FT similar to TR:O85897 (EMBL:AF079317) Sphingomonas FT aromaticivorans hypothetical protein from plasmid pNL1 (450 FT aa), fasta scores; E(): 3.1e-14, 25.3% identity in 372 aa FT overlap" FT /db_xref="InterPro:IPR009553" FT /db_xref="UniProtKB/TrEMBL:Q935K0" FT /protein_id="CAD09774.1" FT /translation="MGQKFAVFIAYDDEPNTKRYSAEFQTQDEYVKGWQSALKKAHHTS FT GQKSVISCGCRGKGAKRLYVRSLPNSDTFILIKAANTGTEHDPSCVFFDLDARHTGLKG FT YASNVVRINNEGTMSIRLGIGMTEKDPPEKSEVPSLPQIQRPEGGQASMTLSGLLSLLW FT TEAGLNVWYPNMAGKRNDSLVRYRMLEAAKQIRSGRACIGDHLFIGVADSKSKVASEQV FT QLLSSAELSDKRLLLLSVLPRYDAEKHEKPLKFLPMRNFGGMPLTFFNSDGHWDSVKRR FT FPLEYAAWKNGGKVVVFALTSPVSVTSRGISARAHQIVLMLVSDNWIPLDSSYEAIVSR FT KLDAEHRHYVKPMRYDASASDVFPDFYLLDTRSDKPFPMEVFGMSTPAYLARKELKKAY FT YNQEYGAYGWWHWDATEKTEYQELPHFPEARR" FT RBS complement(137197..137203) FT /note="possible RBS" FT CDS complement(137218..137388) FT /transl_table=11 FT /gene="HCM1.186c" FT /product="hypothetical protein" FT /note="HCM1.186c, hypothetical protein, len: 56 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935J9" FT /protein_id="CAD09775.1" FT /translation="MMTYFDSAEDLTISKQRALQELAKHGVVASDIDVFFSELGEREEY FT NAQEVLIWLGY" FT RBS complement(137390..137396) FT /note="possible RBS" FT CDS complement(137517..138944) FT /transl_table=11 FT /gene="HCM1.187c" FT /product="putative DNA modification methylase" FT /note="HCM1.187c, probable DNA modification methylase, len: FT 475 aa; similar to many e.g. SW:MTE2_ECOLI (EMBL:X05050) FT Escherichia coli modification methylase EcoRII (EC FT 2.1.1.73) from plasmid N3 (477 aa), fasta scores; E(): 0, FT 66.7% identity in 442 aa overlap. Contains Pfam match to FT entry PF00145 DNA_methylase, C-5 cytosine-specific DNA FT methylase, PS00094 C-5 cytosine-specific DNA methylases FT active site and two PS00095 C-5 cytosine-specific DNA FT methylases C-terminal signature" FT /db_xref="GOA:Q935J8" FT /db_xref="HSSP:6MHT" FT /db_xref="InterPro:IPR001525" FT /db_xref="InterPro:IPR018117" FT /db_xref="UniProtKB/TrEMBL:Q935J8" FT /protein_id="CAD09776.1" FT /translation="MYNDRTEPAITALLNDETPSSIHKLLVQVASIYDVKDLAAQLNAA FT TGSDWSRASLIRQIKGSVNECRITQEEYHYLRSLLPSRPADYDQKFFRFIDLFAGIGGL FT RSGFDAIGGKCVFTSEWNQFSRRTYSANWYCDETEHYFNSDIRDITLSNLPDVSDDQAY FT ASIDASIPDHDVLLAGFPCQPFSIAGVSKKNSLGRKHGFECDTQGTLFFDVARIIRAKQ FT PAIFVLENVKNLKSHDKGNTFRIIMKALDELGYDVADCDAHGSKDPKIIDGKNFRPQHR FT ERIVLVGFRRDLKLHDGFSLSGVSALYPSRRPTLGELLDAEVDSRYILSPKLWEYLYNY FT AKKHQAKGNGFGFGLVNPLDKSVVCRTLSARYYRDGSEILLDRGWDHSIGEKDFNDPVN FT MARRPRRLTPRECARLMGFEQPGKVTFRIPVSDTQAYRQFGNSVIVDVFAAVASLLRSR FT IEIAVAARLKGEFEAAS" FT misc_feature complement(137574..138671) FT /note="Pfam match to entry PF00145 DNA_methylase, C-5 FT cytosine-specific DNA methylase, score 273.90, E-value FT 2e-78" FT misc_feature complement(137580..137636) FT /note="PS00095 C-5 cytosine-specific DNA methylases FT C-terminal signature" FT misc_feature complement(137856..137912) FT /note="PS00095 C-5 cytosine-specific DNA methylases FT C-terminal signature" FT misc_feature complement(138387..138425) FT /note="PS00094 C-5 cytosine-specific DNA methylases active FT site" FT RBS complement(138950..138953) FT /note="possible RBS" FT RBS 139159..139162 FT /note="possible RBS" FT CDS 139168..139683 FT /transl_table=11 FT /gene="HCM1.188" FT /product="putative nuclease" FT /note="HCM1.188, possible nuclease, len: 171 aa; similar to FT SW:NUC_SHIFL (EMBL:U30471), nuc, Shigella flexneri FT micrococcal nuclease precursor (174 aa), fasta scores; E(): FT 9e-07, 38.8% identity in 152 aa overlap and to many FT bacterial hypothetical proteins e.g. SW:YC96_HAEIN FT (EMBL:U32809), HI1296, Haemophilus influenzae hypothetical FT protein (179 aa), fasta scores; E(): 2.1e-20, 41.1% FT identity in 158 aa overlap. Contains Pfam match to entry FT PF00565 SNase, Staphylococcal nuclease homologues. Contains FT a possible N-terminal signal sequence" FT /db_xref="GOA:Q935J7" FT /db_xref="HSSP:1EYC" FT /db_xref="InterPro:IPR006021" FT /db_xref="InterPro:IPR016071" FT /db_xref="UniProtKB/TrEMBL:Q935J7" FT /protein_id="CAD09777.1" FT /translation="MTLLKKLLLPTLIVLFPAATLAAQSSFEAKVVKIIDGDTITALDG FT QNTSIKIRLYGIDAPESKQAFGQKSKQALSAAIAAQNITVIDHGPDIYGRMLGTIWLDG FT YDINASMVDSGYAWVYRFDGNAIVPNYLKFEASAQKAVKGLWVDPNPVAPWEWRQQNQK FT PQKTKSRG" FT misc_feature 139240..139611 FT /note="Pfam match to entry PF00565 SNase, Staphylococcal FT nuclease homologues, score 120.60, E-value 2.9e-32" FT CDS 139680..140612 FT /transl_table=11 FT /gene="HCM1.189" FT /product="hypothetical protein" FT /note="HCM1.189, hypothetical protein, len: 310 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935J6" FT /protein_id="CAD09778.1" FT /translation="MTAMTRQHPLLKIALNSDGHLSWPILPGETHRCPTCLRHVTTGPD FT GDLVHSMEEGGNVCIPSASVVISKAIIEMLSAGERLYVNPIKNGNKTLAPSFIFLHTDQ FT QLRPFINSDYQPAGASWRSDKGFRLGLFFMNERASKINKDQFDFIAVIDPLTFQSEFDA FT TWSRGEFDDPLKALRYSIVSENLSSVWVKWPVKNLQPRKETVMADYWYDYYSPHSPAQQ FT AACTATVTGIDGNVSGETIYMLQIALERSTVEYQLVKSLGVILLLDNTGNLVSEAQPHF FT DIIIKACISGVRDFVLQNPRTLGFENKVA" FT CDS 140668..141447 FT /transl_table=11 FT /gene="HCM1.190" FT /product="hypothetical protein" FT /note="HCM1.190, hypothetical protein, len: 259 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935J5" FT /protein_id="CAD09779.1" FT /translation="MVQVLNTTGLNYQLEKTITEAEERIILISPYLKLSNRIKELIEDK FT NRLKVDIRIVYGKSELNSKEYEWLTNLPFVRLSFCKNLHAKLYANENQCIVCSLNLYDF FT SQINNHEIGVLIIKEQEKDAYTSSLNEAQRLIRISTDNIQPLTTDKETTGSKESEKTNK FT ESSDFTSAFHEEPLTNQNGLITDLNTNSKLTSTNLAKNHKTDLLSLYKKLIEAGYLMDV FT EGKYILTDAGIAAGAEAKPNRYKKGENYFLWPDNLAL" FT CDS 141444..141731 FT /transl_table=11 FT /gene="HCM1.191" FT /product="hypothetical protein" FT /note="HCM1.191, hypothetical protein, len: 95 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935J4" FT /protein_id="CAD09780.1" FT /translation="MILHHVLCPCVAMRDIEGSMKNSLFSTDSNTGVTFTISPHGQGCK FT LSVEPEYRRKGTQNYDGWFPRYYTKPQYAKAALTRFLGEPVNWLDCNDHN" FT CDS 141795..142094 FT /transl_table=11 FT /gene="HCM1.192" FT /product="putative membrane protein" FT /note="HCM1.192, possible membrane protein, len: 99 aa; FT unknown function. Contains hydrophobic, possible FT membrane-spanning regions" FT /db_xref="UniProtKB/TrEMBL:Q935J3" FT /protein_id="CAD09781.1" FT /translation="MENLDVVSAVDFYLEKAFYLFGFIMLGMAWLTFRAGSTYQHFKNA FT DKLVSEGRGSVSSGKEPEMIRRLKFQTLIWYIANCVVLALSTIAFGYLFYLLHS" FT CDS complement(142344..142952) FT /transl_table=11 FT /gene="HCM1.193c" FT /product="hypothetical protein" FT /note="HCM1.193c, hypothetical protein, len: 202 aa; FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q935J2" FT /protein_id="CAD09782.1" FT /translation="MKEKTLDSVSLLISKIRRLDWQRLKEFFGPLAFNHPDCIDAIMTD FT GISTDASFTILNALISRTEMMSSGEYAIEHDRSKNLLTYNERLNFLINCDKEGEFKHSE FT IATISFPLNLKKVYQIDSKESPSVQLCDVLIGACIESVYQLMDSKVLNQNSVLSLYQDS FT QLIHFIPDIDFEGQKKFRKGSQSEEYLTFIQNEIYSSKL" FT repeat_region 142985..142999 FT /note="15 bp inverted repeat flanking IS10" FT repeat_region 142985..144299 FT /note="IS10" FT CDS 143085..144293 FT /transl_table=11 FT /gene="HCM1.194" FT /product="transposase" FT /note="HCM1.194, transposase, len: 402 aa; identical or FT highly similar to Tn10 transposases e.g. TR:AAD50242 FT (EMBL:AF162223) Shigella flexneri IS10-left transposase FT from Tn10 (402 aa), fasta scores; E(): 0, 100.0% identity FT in 402 aa overlap" FT /db_xref="GOA:Q7AQU3" FT /db_xref="InterPro:IPR002559" FT /db_xref="InterPro:IPR012337" FT /db_xref="UniProtKB/TrEMBL:Q7AQU3" FT /protein_id="CAD09783.1" FT /translation="MCELDILHDSLYQFCPELHLKRLNSLTLACHALLDCKTLTLTELG FT RNLPTKARTKHNIKRIDRLLGNRHLHKERLAVYRWHASFICSGNTMPIVLVDWSDIREQ FT KRLMVLRASVALHGRSVTLYEKAFPLSEQCSKKAHDQFLADLASILPSNTTPLIVSDAG FT FKVPWYKSVEKLGWYWLSRVRGKVQYADLGAENWKPISNLHDMSSSHSKTLGYKRLTKS FT NPISCQILLYKSRSKGRKNQRSTRTHCHHPSPKIYSASAKEPWILATNLPVEIRTPKQL FT VNIYSKRMQIEETFRDLKSPAYGLGLRHSRTSSSERFDIMLLIALMLQLTCWLAGVHAQ FT KQGWDKHFQANTVRNRNVLSTVRLGMEVLRHSGYTITREDSLVAATLLTQNLFTHGYVL FT GKL" FT repeat_region complement(144285..144299) FT /note="15 bp inverted repeat flanking IS10" FT CDS 144632..147967 FT /transl_table=11 FT /gene="HCM1.195" FT /product="hypothetical protein" FT /note="HCM1.195, hypothetical protein, len: 1111 aa; FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q935J1" FT /protein_id="CAD09784.1" FT /translation="MGDLVSKNNIDRLERFHSLLAGQYWSALVDIPAEAIVAGDTLLIN FT SLRYVDNNLHTVILRAHPRHYGEWVSVEIVAENGSKSTKDKRLNEHRFLTADFLALFEY FT QPDHEIIRQSELKGIQDEVADLQMRLTETLQDPSALRELAIKRVEDEEASKKGGATEDR FT MLPAVRNAEDVAVTMALGTVQNALSQGISEAQVSLMAKVAEREGKIAGAVANIITSRTG FT AITRALEKMHPYYAELAAAKLAGTQEGIEQASKIQAGVLTLELFVGKNVTVVDVAEGEP FT ADSSIPLTLCQKKLVVDEEFSAWSDIDEHFDFRSLSAFLKALKDNQGLVEQIFPTERCV FT LVMVTTRRFIDYGDTWANAENNEKNSIVFLMVRNGQNIKQIYSPVESHLGASRLFPSED FT EQQGHFRGFDGTTIKFEDVAYTDRLKAHDLMALHYRRLLIMLFGLDQRLALFGQFYPQH FT EKANFLNLSFQERYFHFLHDEDGTGLLASPDSQTLDEFISEKNSYIQPGSRLLCNWREL FT MTPRTAPGAVKEDSGYSGYSFIADPEDNVSAAVVYRQGDTLAVDVAVKRFSTDKMFNCK FT VNVSAYSPWRRGEAELAYLCLDAVGPEELTRFIQQRKFRSNHLFYIRFFKAAIKFLEQE FT RENELPHRQYLLAAMQDSGMHLPGNIQELIHQCIASWKTGNRGVSLAVGMSTEKGRQAL FT LNQLYRLTQGASEMVSVIQEHVAASGSQLLRAGVNSSGNYVAFIAPKPYECDNRLEAHA FT WVHRVVYATGKRNIRETGRSWVSMPERSASEITLWEDEEQSRKWYSMTPVFSSWTEKQK FT LFEMCEKGAGLLKGAMGTPDDEEYGDLLEMWGDAYIACNASGEHVTTPDMFLPVGLIKS FT RKSLKLIALGTCSTEHWMYARAGDDDSRELLLELYTSWYEYPDKARARLLSMAEKNSGL FT RFVLLEGKSRKLERFAVKRPEEIVNWHAGNLKEIPTMLNDQWACHMAMVSQNDKVYLTP FT DLLDDDGLPNFNGVTRQVPGEGYQPVNVYEFESDYFNAVYDADGKKVALCHWYDVTDNS FT YSAEELIGNMPHNAFKFLQYRLDNIEQAEAFIKYRNRNYQPRENADWPEPPEGVKRYVI FT RARS" FT RBS 148723..148729 FT /note="possible RBS" FT CDS 148734..149120 FT /transl_table=11 FT /gene="HCM1.196" FT /product="hypothetical protein" FT /note="HCM1.196, hypothetical protein, len: 128 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5K0" FT /protein_id="CAD09785.1" FT /translation="MGVDMNYEFQKKSPKGWDRVNDNFSNDRSYLLYSWLGLDARNTWG FT VAAITPLRGLPDDIELQWDEDGCDDYWGEHSQTWLLSDEILASTSPVAIEDDEPGSVVA FT EFCAEVQRLHGLHGTVRIVLGFTG" FT CDS complement(149132..149557) FT /transl_table=11 FT /gene="HCM1.197c" FT /product="hypothetical protein" FT /note="HCM1.197c, hypothetical protein, len: 141 aa; FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q9L5J9" FT /protein_id="CAD09786.1" FT /translation="MTDQASIPVDTPVLALATDAYSSLKNILNDNGTSDTTGTCMFASL FT LVCEFAHRRGMSAAVRGGNGTDDGGIFNESGGHGHYWCEVSAGEMIFYIDIAAEQFGYP FT SFIIKNANDVSGWPRYIPGDQVTVDEHVRITLSGGIR" FT RBS complement(149568..149571) FT /note="possible RBS" FT CDS complement(149591..150064) FT /transl_table=11 FT /gene="HCM1.198c" FT /product="hypothetical protein" FT /note="HCM1.198c, hypothetical protein, len: 157 aa; FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q935J0" FT /protein_id="CAD09787.1" FT /translation="MGSIKELLFDIQEEWRHEWISINYPEAEEETLEWDAAAQEYSWFR FT DWMEEAAEQQHFEASLNCIPERLQEALDELHELQGLLETEQLIVSPNLLSELKNLSIQE FT GYMLKIENVLPPNFRVFLVREGFIFPGESWVCGSGYWLPESEVLKNGINSLLV" FT CDS complement(150147..150506) FT /transl_table=11 FT /gene="HCM1.199c" FT /product="hypothetical protein" FT /note="HCM1.199c, hypothetical protein, len: 119 aa; FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q935I9" FT /protein_id="CAD09788.1" FT /translation="MWHNGLPRTVIINNMDVVIRKLIMEISISLDVLFEALMILGHGRV FT WMQEMEFENLPGYSCYRELRTWDNRIVAWWSDADDTWYLCVEVDVITAVPSHIPNKKGE FT LSEEVCFQLMALGRY" FT RBS 151041..151045 FT /note="possible RBS" FT CDS 151052..152449 FT /transl_table=11 FT /gene="HCM1.201" FT /product="putative transposase" FT /note="HCM1.201, possible transposase, len: 465 aa; similar FT to many e.g. SW:TRA2_STRPN (EMBL:U04047) Streptococcus FT pneumoniae transposase for insertion sequence IS1202 (465 FT aa), fasta scores; E(): 8.9e-14, 26.8% identity in 332 aa FT overlap and SW:Y4BF_RHISN (EMBL:AE000065), Y4BF, Rhizobium FT sp. (strain NGR234) putative transposase from plasmid sym FT pNGR234a (457 aa), fasta scores; E(): 0, 44.6% identity in FT 426 aa overlap. Contains a probable helix-turn-helix motif FT at aa 28-49 (Score 1752, +5.15 SD)" FT /db_xref="GOA:Q935I8" FT /db_xref="InterPro:IPR001584" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR012337" FT /db_xref="UniProtKB/TrEMBL:Q935I8" FT /protein_id="CAD09789.1" FT /translation="MAIHDAGMFTVKEINRLKILQDVVERNLRPGQAAEMLGITPRHCS FT RLLKRYRQSGPLGMNNQSRGRTGNRLLPTSLTDQALSIIRERYRDFGPTLAREKLEEVH FT GLVLGKETIRRLMIKAGLWIPRRQRAPKIHQPRYRRPCTGELIQIDGCDHHWFENRGRP FT CTALVYVDDATSRLMHLLFVKSESTFSYFEATRGYIEKYGKPMILYSDKASVFRVNNKH FT ATTGPGETQFARAMRCLNITPLCAETSQAKGRVERAHLTLQDRLVKELRLKGISTIEAA FT NAFAEEYMADYNRRFAKAPLHDFNAHRPLALDDDLDAEFTWREPRRVSKSLTVQYDKML FT YLIEDSEYSRRAIGKYIDVWHYPDGHKELRLNGVLLPYSTYDRLSEVDPVAIVDNKRLG FT HVLDVARQVQKKRDNNRSQSLPSGDEPSRRRHAPGINKSQRSLNEDDLLEAIIKLQGSS FT EAIFGKR" FT CDS 152712..153518 FT /transl_table=11 FT /gene="HCM1.203" FT /product="hypothetical protein" FT /note="HCM1.203, hypothetical protein, len: 268 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935I7" FT /protein_id="CAD09790.1" FT /translation="MYMTGQEINDKKKEYLELLDREENEQIYQTYLEENTMFIPREFEQ FT NHGIHFSTVFRKLPLSSDYKPDFVYLSKSSDNWNVVLVEIEKPSSKYFKNNSTTFHADF FT NLALQQMNTWRAWFDDESNRNHFKNNILQGFIEPAHMGRNPFNFKYVLVHGRRSEYENN FT TQKTALIRGQQRSDFSIISFDSLAENIEKKYKLYVGVKKNSHYELISKEFVDEGIFSWM FT NIDFLAITQSIYDDAIAKSDSWHHYIIKENGTVKTMDYALPRIKII" FT repeat_region complement(153546..153558) FT /note="13 bp inverted repeat flanking IS1" FT repeat_region complement(153546..154293) FT /note="IS1" FT CDS complement(153551..154054) FT /transl_table=11 FT /gene="insB" FT /gene_synonym="HCM1.204c" FT /product="putative IS1 transposase" FT /note="HCM1.204c, insB, possible IS1 transposase, len: 167 FT aa; highly similar to many from Enterobacteriaceae e.g. FT SW:ISB_ECOLI (EMBL:D10483), insB, Escherichia coli FT insertion element IS1 protein InsB (167 aa), fasta scores; FT E(): 0, 97.0% identity in 167 aa overlap" FT /db_xref="GOA:Q7AQU0" FT /db_xref="InterPro:IPR005063" FT /db_xref="UniProtKB/TrEMBL:Q7AQU0" FT /protein_id="CAD09791.1" FT /translation="MPGNRPHYGRWPQHDFPPFKKLRPQSVTSRIQPGSDVIVCAEMDE FT QWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWP FT LYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNI FT KHYQ" FT CDS complement(153973..154248) FT /transl_table=11 FT /gene="insA" FT /gene_synonym="HCM1.205c" FT /product="putative IS1 transposase" FT /note="HCM1.205c, insA, probable IS1 transposase, len: 91 FT aa; highly similar to many from Enterobacteriaceae e.g. FT SW:ISA1_ECOLI (EMBL:X52534), insA, Escherichia coli FT insertion element IS1 protein InsA (91 aa), fasta scores; FT E(): 0, 97.8% identity in 91 aa overlap. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). Contains a probable FT helix-turn-helix motif at aa 64-85 (Score 1462, +4.17 SD)" FT /db_xref="GOA:Q7AQV4" FT /db_xref="InterPro:IPR003220" FT /db_xref="UniProtKB/TrEMBL:Q7AQV4" FT /protein_id="CAD09792.1" FT /translation="MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY FT TASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHLKNSGRSR" FT misc_feature complement(153992..153997) FT /note="possible translational frameshift site, similar to FT that determined experimentally (EMBL:X52534)" FT misc_feature complement(154180..154203) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT repeat_region complement(154281..154293) FT /note="13 bp inverted repeat flanking IS1" FT RBS 154514..154519 FT /note="possible RBS" FT CDS 154527..155186 FT /transl_table=11 FT /gene="cat" FT /gene_synonym="HCM1.206" FT /product="chloramphenicol acetyltransferase" FT /EC_number="2.3.1.28" FT /note="HCM1.206, cat, chloramphenicol acetyltransferase, FT len: 219 aa; highly similar or identical to many e.g. FT SW:CAT_ECOLI (EMBL:V00623), cat, Escherichia coli FT chloramphenicol acetyltransferase (EC 2.3.1.28) (219 aa), FT fasta scores; E(): 0, 100.0% identity in 219 aa overlap. FT Contains Pfam match to entry PF00302 CAT, Chloramphenicol FT acetyltransferase and PS00100 Chloramphenicol FT acetyltransferase active site" FT /db_xref="GOA:P62580" FT /db_xref="InterPro:IPR001707" FT /db_xref="InterPro:IPR018372" FT /db_xref="UniProtKB/Swiss-Prot:P62580" FT /protein_id="CAD09793.1" FT /translation="MEKKITGYTTVDISQWHRKEHFEAFQSVAQCTYNQTVQLDITAFL FT KTVKKNKHKFYPAFIHILARLMNAHPEFRMAMKDGELVIWDSVHPCYTVFHEQTETFSS FT LWSEYHDDFRQFLHIYSQDVACYGENLAYFPKGFIENMFFVSANPWVSFTSFDLNVANM FT DNFFAPVFTMGKYYTQGDKVLMPLAIQVHHAVCDGFHVGRMLNELQQYCDEWQGGA" FT misc_feature 154542..155153 FT /note="Pfam match to entry PF00302 CAT, Chloramphenicol FT acetyltransferase, score 526.70, E-value 1.7e-154" FT misc_feature 155094..155126 FT /note="PS00100 Chloramphenicol acetyltransferase active FT site" FT CDS complement(155387..155764) FT /transl_table=11 FT /gene="HCM1.207c" FT /product="hypothetical protein" FT /note="HCM1.207c, hypothetical protein, len: 125 aa; FT identical to TR:Q9WTH2 (EMBL:AP000342), ybjA, Shigella FT flexneri hypothetical protein from plasmid R100 (125 aa), FT fasta scores; E(): 0, 100.0% identity in 125 aa overlap. FT Also shows weak similarity to other hypothetical proteins FT e.g. TR:O87371 (EMBL:AF051917) Staphylococcus aureus FT hypothetical protein from plasmid pSK41 (130 aa), fasta FT scores; E(): 0.0038, 31.2% identity in 109 aa overlap" FT /db_xref="GOA:Q7AQT8" FT /db_xref="InterPro:IPR000182" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q7AQT8" FT /protein_id="CAD09794.1" FT /translation="MKDYLCKKLFNRLSGTLVIRARCGNNITGLACCNILYPSPRYSGQ FT LHIKELYVSQCDRNKGTGKAIMRFIARLALEQECLSLSWNAEKSNPGANRFYQALGGRI FT NDHIVNYYLHGESLSKLASGI" FT RBS complement(155772..155775) FT /note="possible RBS" FT repeat_region 155823..155834 FT /note="12 bp inverted repeat flanking IS4321" FT repeat_region 155823..157139 FT /note="IS4321" FT CDS complement(156075..157079) FT /transl_table=11 FT /gene="HCM1.209c" FT /product="putative transposase" FT /note="HCM1.209c, probable transposase, len: 334 aa; highly FT similar to many e.g. SW:TRA8_YEREN (EMBL:Z48244) Yersinia FT enterocolitica transposase for insertion sequence element FT IS1328 (334 aa), fasta scores; E(): 0, 66.3% identity in FT 332 aa overlap and TR:P77600 (EMBL:U67194), tnpA, FT Escherichia coli putative transposase from plasmid FT IncP-beta R751 (334 aa), fasta scores; E(): 0, 99.4% FT identity in 334 aa overlap" FT /db_xref="GOA:Q935I6" FT /db_xref="InterPro:IPR002525" FT /db_xref="InterPro:IPR003346" FT /db_xref="UniProtKB/TrEMBL:Q935I6" FT /protein_id="CAD09795.1" FT /translation="MENIALIGIDLGKNSFHIHCQDRRGKAVYRKKFTRPKLIEFLATC FT PATTIAMEACGGSHFMARKLEELGHSPKLISPQFVRPFVKSNKNDFVDAEAICEAASRP FT SMRFVQPRTESQQAMRALHRVRESLVQDKVKTTNQMHAFLLEFGISVPRGAAVISRLST FT ILEDNSLPLYLSQLLLKLQQHYHYLVEQIKDLESQLKRKLDEDEVGQRLLSIPCVGTLT FT ASTISTEIGDGKQYASSRDFAAATGLVPRQYSTGGRTTLLGISKRGNKKIRTLLVQCAR FT VFIQKLEHQSGKLADWVRDLLCRKSNFVVTCALANKLARIAWALTARQQTYVA" FT RBS complement(157087..157090) FT /note="possible RBS" FT repeat_region complement(157128..157139) FT /note="12 bp inverted repeat flanking IS4321" FT CDS complement(join(157158..159638,160461..>160654)) FT /pseudo FT /codon_start=3 FT /transl_table=11 FT /gene="tnpA" FT /gene_synonym="HCM1.210c" FT /product="transposase (pseudogene)" FT /note="HCM1.210c, tnpA, transposase (pseudogene), len: 2481 FT bp; highly similar to many e.g. SW:TRA3_ECOLI FT (EMBL:X04891), tnpA, Escherichia coli transposase for FT transposon TN21 (988 aa), fasta scores; E(): 0, 98.9% FT identity in 826 aa overlap. The N-terminus is truncated. FT Contains Pfam match to entry PF01526 Transposase_7, FT Transposase" FT /db_xref="PSEUDO:CAD09796.1" FT misc_feature complement(157227..159638) FT /note="Pfam match to entry PF01526 Transposase_7, FT Transposase, score 1653.00, E-value 0" FT CDS complement(159604..160230) FT /transl_table=11 FT /gene="HCM1.211c" FT /product="putative transposase" FT /note="HCM1.211c, probable transposase, len: 208 aa; highly FT similar to many e.g. TR:Q52625 (EMBL:X00011) Proteus FT vulgaris transposon Tn 2680 (204 aa), fasta scores; E(): 0, FT 100.0% identity in 197 aa overlap. Has no stop codon within FT the inverted repeats of the putative transposable unit" FT /db_xref="UniProtKB/TrEMBL:Q935I5" FT /protein_id="CAD09797.1" FT /translation="MIAFNHVVPVLNLSVFNVRRAPAFAFEQSKRATIGGRFIRVDESR FT DLPLLHVVEDFTQKPVCSFAVTTGGEIKIDSAAPAVDGPVQIRPAAIDLHVGFIHVPRA FT KIGRVTPVPAQPFFHFRRITLNPAVNRGVIDIHSAFSQHLLQLTVTDAVFAVPAYGPQN FT DVTLKMPAFEWVHVQLHQQKGMISLSPPTICNSARAGECRGDHPC" FT repeat_region complement(159639..159653) FT /note="15 bp inverted repeat flanking IS15/26" FT repeat_region complement(159639..160460) FT /note="IS15/26" FT repeat_region complement(160446..160460) FT /note="15 bp inverted repeat flanking IS15/26" FT misc_feature complement(160461..160655) FT /note="Pfam match to entry PF01526 Transposase_7, FT Transposase, score 76.10, E-value 7.6e-20" FT repeat_region complement(160655..160668) FT /note="14 bp inverted repeat flanking IS15/26" FT repeat_region complement(160655..161474) FT /note="IS15/26" FT CDS complement(160707..161411) FT /transl_table=11 FT /gene="HCM1.213c" FT /product="putative transposase" FT /note="HCM1.213c, probable transposase, len: 234 aa; highly FT similar to many e.g. TR:Q56369 (EMBL:M12900) probable FT transposase from IS15-R (234 aa), fasta scores; E(): 0, FT 99.6% identity in 234 aa overlap. Contains Pfam match to FT entry PF01438 Transposase_3, Transposase" FT /db_xref="GOA:Q7AQT7" FT /db_xref="InterPro:IPR001584" FT /db_xref="InterPro:IPR012337" FT /db_xref="UniProtKB/TrEMBL:Q7AQT7" FT /protein_id="CAD09798.1" FT /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS FT TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF FT YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR FT QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL FT GEMRLVSRVFEM" FT misc_feature complement(160809..161411) FT /note="Pfam match to entry PF01438 Transposase_3, FT Transposase, score 501.80, E-value 5.3e-147" FT RBS complement(161418..161421) FT /note="possible RBS" FT repeat_region complement(161461..161474) FT /note="14 bp inverted repeat flanking IS15/26" FT misc_feature 161477..161701 FT /note="Pfam match to entry PF00239 recombinase, FT Site-specific recombinases, score 106.60, E-value 1.3e-28" FT CDS 161477..161728 FT /pseudo FT /transl_table=11 FT /gene="HCM1.215" FT /product="putative resolvase (pseudogene)" FT /note="HCM1.215, probable resolvase (pseudogene), len: 252 FT bp; similar to many e.g. SW:TNP4_KLEPN (EMBL:M55547), tnpR, FT Klebsiella pneumoniae transposon Tn1331 resolvase from FT plasmid pJHC-MW1 (185 aa), fasta scores; E(): 2e-30, 89.5% FT identity in 95 aa overlap. Contains Pfam match to entry FT PF00239 recombinase, Site-specific recombinases" FT /db_xref="PSEUDO:CAD09799.1" FT RBS 161900..161905 FT /note="possible RBS" FT CDS 161911..162771 FT /transl_table=11 FT /gene="bla" FT /gene_synonym="HCM1.216" FT /product="beta-lactamase" FT /EC_number="3.5.2.6" FT /note="HCM1.216, bla, beta-lactamase, len: 286 aa; highly FT similar to many e.g. SW:BLAT_ECOLI (EMBL:J01749), bla, FT Escherichia coli beta-lactamase precursor encoded by FT several plasmids (EC 3.5.2.6) (286 aa), fasta scores; E(): FT 0, 100.0% identity in 286 aa overlap. Contains Pfam match FT to entry PF00144 beta-lactamase, Beta-lactamase and PS00146 FT Beta-lactamase class-A active site" FT /db_xref="GOA:P62594" FT /db_xref="InterPro:IPR000871" FT /db_xref="InterPro:IPR001466" FT /db_xref="InterPro:IPR012338" FT /db_xref="UniProtKB/Swiss-Prot:P62594" FT /protein_id="CAD09800.1" FT /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYI FT ELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYS FT PVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRW FT EPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSA FT LPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGAS FT LIKHW" FT misc_feature 161992..162768 FT /note="Pfam match to entry PF00144 beta-lactamase, FT Beta-lactamase, score 425.70, E-value 4.2e-124" FT misc_feature 162100..162147 FT /note="PS00146 Beta-lactamase class-A active site" FT CDS 162921..163322 FT /pseudo FT /transl_table=11 FT /gene="HCM1.217" FT /product="hypothetical protein" FT /note="HCM1.217, hypothetical protein, len: 133 aa; unknown FT function, similar to parts of several bacterial FT hypothetical proteins e.g. TR:AAA92748 (EMBL:L06418), sulI, FT Escherichia coli hypothetical protein from plasmid pDGO100 FT (341 aa), fasta scores; E(): 1.3e-29, 76.3% identity in 93 FT aa overlap" FT /db_xref="PSEUDO:CAD09801.1" FT repeat_region 163306..163319 FT /note="14 bp inverted repeat flanking IS15/26" FT repeat_region 163306..164125 FT /note="IS15/26" FT RBS 163359..163362 FT /note="possible RBS" FT misc_feature 163369..163971 FT /note="Pfam match to entry PF01438 Transposase_3, FT Transposase, score 501.80, E-value 5.3e-147" FT CDS 163369..164073 FT /transl_table=11 FT /gene="HCM1.219" FT /product="putative transposase" FT /note="HCM1.219, probable transposase, len: 234 aa; highly FT similar to many e.g. TR:Q56369 (EMBL:M12900) probable FT transposase from IS15-R (234 aa), fasta scores; E(): 0, FT 99.6% identity in 234 aa overlap. Contains Pfam match to FT entry PF01438 Transposase_3, Transposase" FT /db_xref="GOA:Q7AQT7" FT /db_xref="InterPro:IPR001584" FT /db_xref="InterPro:IPR012337" FT /db_xref="UniProtKB/TrEMBL:Q7AQT7" FT /protein_id="CAD09802.1" FT /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS FT TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF FT YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR FT QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL FT GEMRLVSRVFEM" FT repeat_region complement(164112..164125) FT /note="14 bp inverted repeat flanking IS15/26" FT CDS 164126..164842 FT /pseudo FT /transl_table=11 FT /gene="HCM1.220" FT /product="putative replication initiation protein FT (pseudogene)" FT /note="HCM1.220, probable replication initiation protein FT (pseudogene), len: 717 bp; highly similar to SW:REPJ_ECOLI FT (EMBL:M28829), repA, Escherichia coli regulatory protein FT from plasmid IncQ RSF1010 (279 aa), fasta scores; E(): 0, FT 100.0% identity in 235 aa overlap. N-terminus is truncated" FT CDS 164829..165680 FT /transl_table=11 FT /gene="HCM1.221" FT /product="putative replication protein" FT /note="HCM1.221, probable replication protein, len: 283 aa; FT highly similar to TR:Q52351 (EMBL:M28829), repC, FT Escherichia coli replication protein from plasmid IncQ FT RSF1010 (283 aa), fasta scores; E(): 0, 98.6% identity in FT 283 aa overlap. Contains PS00017 ATP/GTP-binding site motif FT A (P-loop)" FT /db_xref="InterPro:IPR010522" FT /db_xref="UniProtKB/TrEMBL:Q935I4" FT /protein_id="CAD09804.1" FT /translation="MVKPKNKHSLSHVRHDPAHCLAPGLFRALKRGERKRSKLDVTYDY FT GDGKRIEFSGPEPLGADDLRILQGLVAMAGPNGLVLGPEPKTEGGRQLRLFLEPKWEAV FT TADAMVVKGSYRALAKEIGAEVDSGGALKHIQDCIERLWKVSIIAQNGRKRQGFRLLSE FT YASDEADGRLYVALNPLIAQAVMGGGQHVRISMDEVRALDSETARLLHQRLCGWIDPGK FT TGKASIDTLCGYVWPSEASGSTMRKRRQRVREALPELVALGWTVTEFAAGKYDITRPKA FT AG" FT misc_feature 165474..165497 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT CDS 165988..166803 FT /transl_table=11 FT /gene="HCM1.222" FT /product="dihydropteroate synthase" FT /EC_number="2.5.1.15" FT /note="HCM1.222, dihydropteroate synthase, len: 271 aa; FT highly similar to many e.g. SW:DHP2_ECOLI (EMBL:M36657), FT sulII, Escherichia coli dihydropteroate synthase type II FT encoded by several plasmids (EC 2.5.1.15) (271 aa), fasta FT scores; E(): 0, 99.6% identity in 271 aa overlap. Contains FT Pfam match to entry PF00809 DHPS, Dihydropteroate synthase FT and PS00792 Dihydropteroate synthase signature 1" FT /db_xref="GOA:Q935I3" FT /db_xref="HSSP:1EYE" FT /db_xref="InterPro:IPR000489" FT /db_xref="InterPro:IPR006390" FT /db_xref="InterPro:IPR011005" FT /db_xref="UniProtKB/TrEMBL:Q935I3" FT /protein_id="CAD09805.1" FT /translation="MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVI FT DLGPASSNPDAAPVSSDTEIERIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLN FT DIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTG FT AGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGR FT GPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLAVLAALKETARIR" FT misc_feature 166006..166053 FT /note="PS00792 Dihydropteroate synthase signature 1" FT misc_feature 166009..166776 FT /note="Pfam match to entry PF00809 DHPS, Dihydropteroate FT synthase, score 433.90, E-value 1.4e-126" FT misc_feature 166108..166149 FT /note="PS00793 Dihydropteroate synthase signature 2" FT RBS 166852..166856 FT /note="possible RBS" FT misc_feature 166864..167658 FT /note="Pfam match to entry PF01636 APH, Aminoglycoside FT phosphotransferase, score 454.70, E-value 7.7e-133" FT CDS 166864..167667 FT /transl_table=11 FT /gene="strA" FT /gene_synonym="HCM1.223" FT /product="streptomycin phosphotransferase" FT /note="HCM1.223, strA, streptomycin phosphotransferase, FT len: 267 aa; highly similar to many e.g. TR:Q57009 FT (EMBL:M95402), strA, Erwinia amylovora streptomycin FT phosphotransferase from plasmid pEa34 (267 aa), fasta FT scores; E(): 0, 99.6% identity in 267 aa overlap and FT SW:APHE_STRGR (EMBL:X53527), aphE, Streptomyces griseus FT streptomycin 3''-kinase (EC 2.7.1.87) (272 aa), fasta FT scores; E(): 0, 51.1% identity in 262 aa overlap. Contains FT Pfam match to entry PF01636 APH, Aminoglycoside FT phosphotransferase" FT /db_xref="GOA:Q7AQT5" FT /db_xref="InterPro:IPR002575" FT /db_xref="InterPro:IPR011009" FT /db_xref="UniProtKB/TrEMBL:Q7AQT5" FT /protein_id="CAD09806.1" FT /translation="MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRR FT GELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPS FT MGQQLGAVHSLSVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARV FT ERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIA FT NAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG" FT CDS 167667..168503 FT /transl_table=11 FT /gene="strB" FT /gene_synonym="HCM1.224" FT /product="streptomycin phosphotransferase" FT /note="HCM1.224, strB, streptomycin phosphotransferase, FT len: 278 aa; highly similar to many e.g. TR:Q57204 FT (EMBL:M95402), strB, Erwinia amylovora streptomycin FT phosphotransferase from plasmid pEa34 (278 aa), fasta FT scores; E(): 0, 100.0% identity in 278 aa overlap" FT /db_xref="GOA:Q7AQT4" FT /db_xref="InterPro:IPR006748" FT /db_xref="InterPro:IPR011009" FT /db_xref="UniProtKB/TrEMBL:Q7AQT4" FT /protein_id="CAD09807.1" FT /translation="MFMPPVFPAHWHVSQPVLIADTFSSLVWKVSLPDGTPAIVKGLKP FT IEDIADELRGADYLVWRNGRGAVRLLGRENNLMLLEYAGERMLSHIVAEHGDYQATEIA FT AELMAKLYAASEEPLPSALLPIRDRFAALFQRARDDQNAGCQTDYVHAAIIADQMMSNA FT SELRGLHGDLHHENIMFSSRGWLVIDPVGLVGEVGFGAANMFYDPADRDDLCLDPRRIA FT QMADAFSRALDVDPRRLLDQAYAYGCLSAAWNADGEEEQRDLAIAAAIKQVRQTSY" FT repeat_region 168511..168525 FT /note="15 bp inverted repeat flanking IS15/26" FT repeat_region 168511..169332 FT /note="IS15/26" FT CDS 168741..169361 FT /transl_table=11 FT /gene="HCM1.225" FT /product="putative transposase" FT /note="HCM1.225, probable transposase, len: 206 aa; highly FT similar to many e.g. TR:Q52625 (EMBL:X00011) Proteus FT vulgaris transposon Tn 2680 (204 aa), fasta scores; E(): 0, FT 99.5% identity in 197 aa overlap. Has no stop codon within FT the inverted repeats of the putative transposable unit" FT /db_xref="UniProtKB/TrEMBL:Q935I2" FT /protein_id="CAD09808.1" FT /translation="MIAFNHVVPVLNLSVFNVRRAPAFAFEQSKRATIGGRFIRVDESR FT DLPLLHVVEDFTQKPVCSFAVTTGGEIKIDSAAPAVNGPVQIRPAAIDLHVGFIHVPRA FT KIGRVTPVPAQPFFHFRRITLNPAVNRGVIDIHSAFSQHLLQLTVTDAVFAVPAYGPQN FT DVTLKMPAFEWVHVQLHQQKGMISLSPPTICNSAHRRSSGCGR" FT repeat_region complement(169318..169332) FT /note="15 bp inverted repeat flanking IS15/26" FT CDS complement(169333..170619) FT /pseudo FT /transl_table=11 FT /gene="HCM1.226c" FT /product="putative transposase (pseudogene)" FT /note="HCM1.226c, possible transposase (pseudogene), len: FT 429 aa; highly similar to many e.g. TR:Q56381 FT (EMBL:U42226), tniA, Shigella flexneri possible transposase FT from plasmid R100 (571 aa), fasta scores; E(): 0, 100.0% FT identity in 429 aa overlap. Truncated at the C-terminus" FT CDS complement(170658..171365) FT /transl_table=11 FT /gene="HCM1.227c" FT /product="hypothetical protein" FT /note="HCM1.227c, hypothetical protein, len: 235 aa; FT similar to many hypothetical proteins e.g. TR:Q9WTI2 FT (EMBL:AP000342), yaeA, Shigella flexneri hypothetical FT protein from plasmid R100 (235 aa), fasta scores; E(): 0, FT 100.0% identity in 235 aa overlap. Contains Pfam match to FT entry PF00563 DUF2, Domain of unknown function 2" FT /db_xref="InterPro:IPR001633" FT /db_xref="UniProtKB/TrEMBL:Q7AQT3" FT /protein_id="CAD09810.1" FT /translation="MTSSQPAGWTAAELAQAAARGQLDLHYQPLVDLRDHRIAGAEALM FT RWRHPRLGLLPPGQFLPLAESFGLMPEIGAWVLGEACRQMHKWQGPAWQPFRLAINVSA FT SQVGPTFDDEVKRVLADMALPAELLEIELTESVAFGNPALFASFDALRAIGVRFAADDF FT GTGYSCLQHLKCCPITTLKIDQSFVARLPDDARDQTIVRAVIQLAHGLGMDVIFRRRLH FT QLIGRNGCCAASS" FT misc_feature complement(170664..171338) FT /note="Pfam match to entry PF00563 DUF2, Domain of unknown FT function 2, score 197.30, E-value 2.4e-55" FT CDS complement(171362..171598) FT /transl_table=11 FT /gene="HCM1.229c" FT /product="hypothetical protein" FT /note="HCM1.229c, hypothetical protein, len: 78 aa; highly FT similar to ORFs from transposable elements containing FT mer-operons e.g. TR:Q57069 (EMBL:X03405), merE, Pseudomonas FT aeruginosa hypothetical protein from plasmid R100 (78 aa), FT fasta scores; E(): 1.3e-22, 98.7% identity in 78 aa FT overlap" FT /db_xref="InterPro:IPR007746" FT /db_xref="UniProtKB/TrEMBL:Q7AQT2" FT /protein_id="CAD09811.1" FT /translation="MNAPDKLPPETRQPVSGYLWGALAVLTCPCHLPILAAVLAGTTAG FT AFLGEHWGVAALALTGLFVLAVTRLLRAFRGGS" FT CDS complement(171595..171957) FT /transl_table=11 FT /gene="merD" FT /gene_synonym="HCM1.230c" FT /product="putative mercuric resistance operon coregulator" FT /note="HCM1.230c, merD, probable mercuric resistance operon FT coregulator, len: 120 aa; highly similar to many e.g. FT SW:MERD_SHIFL (EMBL:L29404), merD, Shigella flexneri FT mercuric resistance protein from plasmid IncFII NR1 (120 FT aa), fasta scores; E(): 0, 99.2% identity in 120 aa FT overlap. Similar to HCM1.159, merD, probable mercuric FT resistance operon coregulator (121 aa), fasta scores; E(): FT 0, 82.6% identity in 121 aa overlap" FT /db_xref="GOA:Q7AQT1" FT /db_xref="InterPro:IPR000551" FT /db_xref="InterPro:IPR009061" FT /db_xref="InterPro:IPR011797" FT /db_xref="UniProtKB/TrEMBL:Q7AQT1" FT /protein_id="CAD09812.1" FT /translation="MSAYTVSQLAHNAGVSVHIVRDYLVRGLLRPVACTTGGYGVFDDA FT ALQRLCFVRAAFEAGIGLDALARLCRALDAADGAQAAAQLAVLRQLVERRRAALAHLDA FT QLASMPAERAHEEALP" FT RBS complement(171606..171611) FT /note="possible RBS" FT RBS complement(171963..171970) FT /note="possible RBS" FT CDS complement(171975..173669) FT /transl_table=11 FT /gene="merA" FT /gene_synonym="HCM1.231c" FT /product="putative mercuric reductase" FT /EC_number="1.16.1.1" FT /note="HCM1.231c, merA, probable mercuric reductase, len: FT 564 aa; highly similar to many e.g. SW:MERA_SHIFL FT (EMBL:J01730), merA, Shigella flexneri mercuric reductase FT from plasmid IncFII NR1 (EC 1.16.1.1) (564 aa), fasta FT scores; E(): 0, 99.6% identity in 564 aa overlap. Contains FT Pfam matches to entry PF00403 HMA, Heavy-metal-associated FT domain and to entry PF00070 pyr_redox, Pyridine FT nucleotide-disulphide oxidoreductase class-I. Contains FT PS01047 Heavy-metal-associated domain and PS00076 Pyridine FT nucleotide-disulphide oxidoreductases class-I active site. FT Similar to HCM1.158, merA, probable mercuric reductase (561 FT aa), fasta scores; E(): 0, 85.0% identity in 565 aa FT overlap" FT /db_xref="GOA:Q7AQT0" FT /db_xref="HSSP:1AFJ" FT /db_xref="InterPro:IPR000815" FT /db_xref="InterPro:IPR001327" FT /db_xref="InterPro:IPR004099" FT /db_xref="InterPro:IPR006121" FT /db_xref="InterPro:IPR011796" FT /db_xref="InterPro:IPR012999" FT /db_xref="InterPro:IPR013027" FT /db_xref="InterPro:IPR016156" FT /db_xref="InterPro:IPR017969" FT /db_xref="UniProtKB/TrEMBL:Q7AQT0" FT /protein_id="CAD09813.1" FT /translation="MSTLKITGMTCDSCAVHVKDALEKVPGVQSADVSYAKGSAKLAIE FT VGTSPDALTAAVAGLGYRATLADAPSVSTPGGLLDKMRDLLGRNDKTGSSGALHIAVIG FT SGGAAMAAALKAVEQGARVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDG FT GIAATTPTIQRTALLAQQQARVDELRHAKYEGILEGNPAITVLHGSARFKDNRNLIVQL FT NDGGERVVAFDRCLIATGASPAVPPIPGLKDTPYWTSTEALVSETIPKRLAVIGSSVVA FT LELAQAFARLGAKVTILARSTLFFREDPAIGEAVTAAFRMEGIEVREHTQASQVAYING FT EGDGEFVLTTAHGELRADKLLVATGRAPNTRKLALDATGVTLTPQGAIVIDPGMRTSVE FT HIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALNLTAMPAVVFTDPQVATVGYSEA FT EAHHDGIKTDSRTLTLDNVPRALANFDTRGFIKLVVEEGSGRLIGVQAVAPEAGELIQT FT AALAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCCAG" FT misc_feature complement(171996..173372) FT /note="Pfam match to entry PF00070 pyr_redox, Pyridine FT nucleotide-disulphide oxidoreductase class-I, score 736.50, FT E-value 1.2e-217" FT misc_feature complement(173244..173276) FT /note="PS00076 Pyridine nucleotide-disulphide FT oxidoreductases class-I active site" FT misc_feature complement(173472..173666) FT /note="Pfam match to entry PF00403 HMA, FT Heavy-metal-associated domain, score 84.70, E-value FT 9.7e-23" FT misc_feature complement(173565..173654) FT /note="PS01047 Heavy-metal-associated domain" FT RBS complement(173678..173683) FT /note="possible RBS" FT CDS complement(173721..174143) FT /transl_table=11 FT /gene="merC" FT /gene_synonym="HCM1.232c" FT /product="putative mercury transport protein" FT /note="HCM1.232c, merC, probable mercury transport protein, FT len: 140 aa; highly similar to many e.g. TR:O66048 FT (EMBL:U90263), merC, Pseudomonas stutzeri MerC protein from FT plasmid pPB (141 aa), fasta scores; E(): 0, 63.5% identity FT in 137 aa overlap. Contains hydrophobic, probable FT membrane-spanning regions. Similar to HCM1.157, merC, FT probable mercury transport protein (141 aa), fasta scores; FT E(): 0, 73.0% identity in 141 aa overlap" FT /db_xref="InterPro:IPR004891" FT /db_xref="UniProtKB/TrEMBL:Q7AQS9" FT /protein_id="CAD09814.1" FT /translation="MGLMTRIADKTGALGSVVSAMGCAACFPALASFGAAIGLGFLSQY FT EGLFISRLLPLFAALAFLANALGWFSHRQWLRSLLGMIGPAIVFAATVWLLGNWWTANL FT MYVGLALMIGVSIWDFVSPAHRRCGPDGCELPAKRL" FT CDS complement(174179..174454) FT /transl_table=11 FT /gene="merP" FT /gene_synonym="HCM1.233c" FT /product="putative mercuric transport protein periplasmic FT binding protein" FT /note="HCM1.233c, merP, probable mercuric transport protein FT periplasmic binding protein, len: 91 aa; highly similar to FT many e.g. SW:MERP_SHIFL (EMBL:J01730), merP, Shigella FT flexneri mercuric transport protein periplasmic component FT precursor from plasmid IncFII NR1 (91 aa), fasta scores; FT E(): 5.1e-32, 98.9% identity in 91 aa overlap. Contains FT Pfam match to entry PF00403 HMA, Heavy-metal-associated FT domain and PS01047 Heavy-metal-associated domain. Contains FT a probable N-terminal signal sequence. Similar to HCM1.153, FT merP, probable mercuric transport protein periplasmic FT binding protein (91 aa), fasta scores; E(): 6.4e-31, 82.4% FT identity in 91 aa overlap" FT /db_xref="GOA:Q935I1" FT /db_xref="HSSP:1AFJ" FT /db_xref="InterPro:IPR001757" FT /db_xref="InterPro:IPR001802" FT /db_xref="InterPro:IPR006121" FT /db_xref="InterPro:IPR011795" FT /db_xref="InterPro:IPR017969" FT /db_xref="UniProtKB/TrEMBL:Q935I1" FT /protein_id="CAD09815.1" FT /translation="MKKLFASLALAAAVAPVWAATQTVTLAVPGMTCVACPITVKKALS FT KVEGVSKVDVGFEKREAVVTFDDTKASVQKLTKATADAGYPSSVKQ" FT misc_feature complement(174188..174385) FT /note="Pfam match to entry PF00403 HMA, FT Heavy-metal-associated domain, score 95.50, E-value FT 7.9e-26" FT misc_feature complement(174284..174373) FT /note="PS01047 Heavy-metal-associated domain" FT RBS complement(174461..174465) FT /note="possible RBS" FT CDS complement(174468..174818) FT /transl_table=11 FT /gene="merT" FT /gene_synonym="HCM1.234c" FT /product="putative mercuric transport protein" FT /note="HCM1.234c, merT, probable mercuric transport FT protein, len: 116 aa; highly similar to many e.g. FT SW:MERT_SHIFL (EMBL:J01730), merT, Shigella flexneri FT mercuric transport protein from plasmid IncFII NR1 (116 FT aa), fasta scores; E(): 0, 100.0% identity in 116 aa FT overlap. Contains hydrophobic, probable membrane-spanning FT regions. Similar to HCM1.152, merT, probable mercuric FT transport protein (121 aa), fasta scores; E(): 0, 93.0% FT identity in 115 aa overlap" FT /db_xref="GOA:P0A219" FT /db_xref="InterPro:IPR003457" FT /db_xref="UniProtKB/Swiss-Prot:P0A219" FT /protein_id="CAD09816.1" FT /translation="MSEPQNGRGALFAGGLAAILASTCCLGPLVLVALGFSGAWIGNLT FT VLEPYRPLFIGAALVALFFAWKRIYRPVQACKPGEVCAIPQVRATYKLIFWIVAVLVLV FT ALGFPYVVPFFY" FT RBS 174877..174880 FT /note="possible RBS" FT CDS 174890..175324 FT /transl_table=11 FT /gene="merR" FT /gene_synonym="HCM1.235" FT /product="putative mercuric resistance operon regulatory FT protein" FT /note="HCM1.235, merR, probable mercuric resistance operon FT regulatory protein, len: 144 aa; highly similar to many FT e.g. SW:MERR_SHIFL (EMBL:K03089), merR, Shigella flexneri FT mercuric resistance operon regulatory protein from plasmid FT IncFII NR1 (144 aa), fasta scores; E(): 0, 100.0% identity FT in 144 aa overlap. Contains Pfam match to entry PF00376 FT merR, Bacterial regulatory proteins, merR family and FT PS00552 Bacterial regulatory proteins, merR family FT signature. Contains a probable helix-turn-helix motif at aa FT 8-29 (Score 1571, +4.54 SD). Similar to HCM1.151c, merR, FT probable mercuric resistance operon regulatory protein (151 FT aa), fasta scores; E(): 0, 89.4% identity in 142 aa FT overlap" FT /db_xref="GOA:P0A2Q8" FT /db_xref="InterPro:IPR000551" FT /db_xref="InterPro:IPR009061" FT /db_xref="InterPro:IPR011794" FT /db_xref="InterPro:IPR015358" FT /db_xref="UniProtKB/Swiss-Prot:P0A2Q8" FT /protein_id="CAD09817.1" FT /translation="MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRR FT YGEADVVRVKFVKSAQRLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLA FT RMETVLSELVCACHARKGNVSCPLIASLQGEAGLARSAMP" FT misc_feature 174920..174976 FT /note="Pfam match to entry PF00376 merR, Bacterial FT regulatory proteins, merR family, score 29.10, E-value FT 7.8e-05" FT misc_feature 174920..174988 FT /note="PS00552 Bacterial regulatory proteins, merR family FT signature" FT misc_feature 174920..175027 FT /note="Pfam match to entry PF00376 merR, Bacterial FT regulatory proteins, merR family, score 64.40, E-value FT 2.4e-15" FT repeat_region 175343..175354 FT /note="12 bp inverted repeat flanking IS4321" FT repeat_region 175343..176659 FT /note="IS4321" FT RBS 175392..175395 FT /note="possible RBS" FT CDS 175403..176407 FT /transl_table=11 FT /gene="HCM1.236" FT /product="putative transposase" FT /note="HCM1.236, probable transposase, len: 334 aa; highly FT similar to many e.g. SW:TRA8_YEREN (EMBL:Z48244) Yersinia FT enterocolitica transposase for insertion sequence element FT IS1328 (334 aa), fasta scores; E(): 0, 66.3% identity in FT 332 aa overlap and TR:P77600 (EMBL:U67194), tnpA, FT Escherichia coli putative transposase from plasmid FT IncP-beta R751 (334 aa), fasta scores; E(): 0, 97.3% FT identity in 334 aa overlap" FT /db_xref="GOA:Q934H6" FT /db_xref="InterPro:IPR002525" FT /db_xref="InterPro:IPR003346" FT /db_xref="UniProtKB/TrEMBL:Q934H6" FT /protein_id="CAD09818.1" FT /translation="MENIALIGIDLGKNSFHIHCQDHRGKAVYRKKFTRPKLIEFLATC FT PATTIAMEACGGSHFMARKLAELGHFPKLISPQFVRPFVKSNKNDFVDAEAICEAASRP FT SMRFVQPRTESQQAMRALHRVRESLVQDKVKTTNQMHAFLLEFGISVPRGAAVISRLST FT LLEDSSLPLYLSQLLLKLQQHYHYLVEQIKDLESQLKRKLDEDEVGQRLLSIPCVGTLT FT ASTISTEIGDGKQYASSRDFAAATGLVPRQYSTGGRTTLLGISKRGNKKIRTLLVQCAR FT VFIQKLEHQSGKLADWVRELLCRKSNFVVTCALANKLARIAWALTARQQTYEA" FT repeat_region complement(176648..176659) FT /note="12 bp inverted repeat flanking IS4321" FT repeat_region complement(176752..177500) FT /note="IS1" FT repeat_region 176753..176765 FT /note="13 bp inverted repeat flanking IS1" FT CDS complement(176758..177261) FT /transl_table=11 FT /gene="insB" FT /gene_synonym="HCM1.238c" FT /product="putative IS1 transposase" FT /note="HCM1.238c, insB, possible IS1 transposase, len: 167 FT aa; highly similar to many from Enterobacteriaceae e.g. FT SW:ISB_ECOLI (EMBL:D10483), insB, Escherichia coli FT insertion element IS1 protein InsB (167 aa), fasta scores; FT E(): 0, 97.0% identity in 167 aa overlap" FT /db_xref="GOA:Q7AQU0" FT /db_xref="InterPro:IPR005063" FT /db_xref="UniProtKB/TrEMBL:Q7AQU0" FT /protein_id="CAD09819.1" FT /translation="MPGNRPHYGRWPQHDFPPFKKLRPQSVTSRIQPGSDVIVCAEMDE FT QWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWP FT LYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNI FT KHYQ" FT CDS complement(177180..177455) FT /transl_table=11 FT /gene="insA" FT /gene_synonym="HCM1.239c" FT /product="putative IS1 transposase" FT /note="HCM1.239c, insA, probable IS1 transposase, len: 91 FT aa; highly similar to many from Enterobacteriaceae e.g. FT SW:ISA1_ECOLI (EMBL:X52534), insA, Escherichia coli FT insertion element IS1 protein InsA (91 aa), fasta scores; FT E(): 0, 97.8% identity in 91 aa overlap. Contains PS00017 FT ATP/GTP-binding site motif A (P-loop). Contains a probable FT helix-turn-helix motif at aa 64-85 (Score 1462, +4.17 SD)" FT /db_xref="GOA:Q7AQV4" FT /db_xref="InterPro:IPR003220" FT /db_xref="UniProtKB/TrEMBL:Q7AQV4" FT /protein_id="CAD09820.1" FT /translation="MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY FT TASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHLKNSGRSR" FT misc_feature complement(177199..177204) FT /note="possible translational frameshift site, similar to FT that determined experimentally (EMBL:X52534)" FT misc_feature complement(177387..177410) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT repeat_region complement(177488..177500) FT /note="13 bp inverted repeat flanking IS1" FT CDS 177511..177822 FT /pseudo FT /transl_table=11 FT /gene="HCM1.240" FT /product="hypothetical protein (pseudogene)" FT /note="HCM1.240, probable pseudogene, len: 312 bp; highly FT similar to part of SW:TETC_ECOLI (EMBL:J01830), tetC, FT Escherichia coli transposon Tn10 protein (197 aa), fasta FT scores; E(): 0, 99.0% identity in 103 aa overlap. Truncated FT at the N-terminus" FT CDS complement(177935..179140) FT /transl_table=11 FT /gene="tetA" FT /gene_synonym="HCM1.241c" FT /product="tetracycline resistance protein" FT /note="HCM1.241c, tetA, tetracycline resistance protein, FT len: 401 aa; highly similar to many e.g. SW:TCR2_ECOLI FT (EMBL:V00611), tetA, Escherichia coli tetracycline FT resistance protein, class B (401 aa), fasta scores; E(): 0, FT 99.8% identity in 401 aa overlap. Contains PS00216 Sugar FT transport proteins signature 1. Contains hydrophobic, FT probable membrane-spanning regions" FT /db_xref="GOA:Q7BN13" FT /db_xref="InterPro:IPR001958" FT /db_xref="InterPro:IPR005829" FT /db_xref="InterPro:IPR011701" FT /db_xref="InterPro:IPR016196" FT /db_xref="UniProtKB/TrEMBL:Q7BN13" FT /protein_id="CAD09822.1" FT /translation="MNSSTKIALVITLLDAMGIGLIMPVLPTLLREFIASEDIANHFGV FT LLALYALMQVIFAPWLGKMSDRFGRRPVLLLSLIGASLDYLLLAFSSALWMLYLGRLLS FT GITGATGAVAASVIADTTSASQRVKWFGWLGASFGLGLIAGPIIGGFAGEISPHSPFFI FT AALLNIVAFLVVMFWFRETKNTRDNTDTEVGVETQSNSVYITLFKTMPILLIIYFSAQL FT IGQIPATVWVLFTENRFGWNSMMVGFSLAGLGLLHSVFQAFVAGRIATKWGEKTAVLLG FT FIADSSAFAFLAFISEGWLVFPVLILLAGGGIALPALQGVMSIQTKSHQQGALQGLLVS FT LTNATGVIGPLLFAVIYNHSLPIWDGWIWIIGLAFYCIIILLSMTFMLTPQAQGSKQET FT SA" FT misc_feature complement(178910..178960) FT /note="PS00216 Sugar transport proteins signature 1" FT CDS 179219..179845 FT /transl_table=11 FT /gene="tetR" FT /gene_synonym="HCM1.243" FT /product="tetracycline repressor protein" FT /note="HCM1.243, tetR, tetracycline repressor protein, len: FT 208 aa; highly similar to many e.g. SW:TER2_ECOLI FT (EMBL:X00694), tetR, Escherichia coli tetracycline FT repressor protein (207 aa), fasta scores; E(): 0, 100.0% FT identity in 207 aa overlap. Contains Pfam match to entry FT PF00440 tetR, Bacterial regulatory proteins, tetR family FT and PS01081 Bacterial regulatory proteins, tetR family FT signature. Contains a probable helix-turn-helix motif at aa FT 26-47 (Score 2218, +6.74 SD)" FT /db_xref="GOA:Q9S455" FT /db_xref="HSSP:1A6I" FT /db_xref="InterPro:IPR001647" FT /db_xref="InterPro:IPR003012" FT /db_xref="InterPro:IPR004111" FT /db_xref="InterPro:IPR009057" FT /db_xref="InterPro:IPR011075" FT /db_xref="InterPro:IPR012287" FT /db_xref="InterPro:IPR015893" FT /db_xref="UniProtKB/TrEMBL:Q9S455" FT /protein_id="CAD09823.1" FT /translation="MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWH FT VKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGT FT RPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPT FT TDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS" FT misc_feature 179246..179386 FT /note="Pfam match to entry PF00440 tetR, Bacterial FT regulatory proteins, tetR family, score 88.40, E-value FT 8e-23" FT misc_feature 179282..179374 FT /note="PS01081 Bacterial regulatory proteins, tetR family FT signature" FT misc_feature 179294..179359 FT /note="Pfam match to entry PF00440 tetR, Bacterial FT regulatory proteins, tetR family, score 28.50, E-value FT 3.7e-06" FT CDS complement(179823..180509) FT /transl_table=11 FT /gene="HCM1.244c" FT /product="putative transcriptional regulator" FT /note="HCM1.244c, possible transcriptional regulator, len: FT 228 aa; similar to e.g. TR:AAD50245 (EMBL:AF162223), jemC, FT Shigella flexneri hypothetical protein from transposon Tn10 FT (228 aa), fasta scores; E(): 0, 99.6% identity in 228 aa FT overlap. Contains Pfam match to entry PF01022 HTH_5, FT Bacterial regulatory protein, arsR family. Contains a FT probable helix-turn-helix motif at aa 40-61 (Score 1172, FT +3.18 SD)" FT /db_xref="GOA:Q935I0" FT /db_xref="InterPro:IPR001845" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q935I0" FT /protein_id="CAD09824.1" FT /translation="MANLIRKEVTFESSIAAIGAAMSDISRVKILSALMDGRAWTATEL FT SSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELMESMMGISLNHGVH FT ARVSTPVHLRKARTCYDHLAGEVAVKIYDSLCQQQWITENGSMITLSGIQYFHEMGIDV FT PSKHSRKICCACLDWSERRFHLGGYVGAALFSLYESKGWLTRHLGYREVTITEKGYAAF FT KTHFHI" FT misc_feature complement(180219..180455) FT /note="Pfam match to entry PF01022 HTH_5, Bacterial FT regulatory protein, arsR family, score 46.40, E-value FT 6.2e-10" FT CDS complement(180517..180903) FT /transl_table=11 FT /gene="HCM1.245c" FT /product="hypothetical protein" FT /note="HCM1.245c, hypothetical protein, len: 128 aa; FT unknown function, identical to TR:Q9WTF2 (EMBL:AP000342), FT ydjB, Shigella flexneri hypothetical protein from plasmid FT R100 (162 aa), fasta scores; E(): 0, 100.0% identity in 162 FT aa overlap" FT /db_xref="UniProtKB/TrEMBL:Q935H9" FT /protein_id="CAD09825.1" FT /translation="MFDVHVVLDNQIGQLALLGKTLGNKGIGLEGGGIFTVGDECHAHF FT LVEQGKEAKIALEQAGLLVLAIRTPLIRKLKQEKPGELGEIARVLAENNINILVQYSDH FT ANQLILITDNDSMAASVTLPWAIK" FT CDS complement(180896..181216) FT /transl_table=11 FT /gene="HCM1.246c" FT /product="hypothetical protein" FT /note="HCM1.246c, hypothetical protein, len: 106 aa; FT unknown function, identical to TR:Q9WTF3 (EMBL:AP000342), FT ydjA, Shigella flexneri hypothetical protein from plasmid FT R100 (106 aa), fasta scores; E(): 0, 100.0% identity in 106 FT aa overlap" FT /db_xref="GOA:Q7BN17" FT /db_xref="InterPro:IPR007138" FT /db_xref="InterPro:IPR011008" FT /db_xref="UniProtKB/TrEMBL:Q7BN17" FT /protein_id="CAD09826.1" FT /translation="MIAVIFEVQIQPDQQTRYLTLAEELRPLLSHVAGFISIERFQSLA FT TEGKMLSLSWWENEYAVLQWKNHVLHAKAQQEGRESIFDFYKISIAHITREYSFKKDKD FT NV" FT RBS complement(180906..180910) FT /note="possible RBS" FT RBS complement(181223..181226) FT /note="possible RBS" FT CDS 181660..182864 FT /pseudo FT /transl_table=11 FT /gene="HCM1.247" FT /product="putative glutamate permease (pseudogene)" FT /note="HCM1.247, probable glutamate permease (pseudogene), FT len: 1205 bp; highly similar to SW:GLTS_ECOLI FT (EMBL:D00626), gltS, Escherichia coli sodium/glutamate FT symport carrier protein (401 aa), fasta scores; E(): 0, FT 54.5% identity in 288 aa overlap and E(): 2.8e-11, 40.8% FT identity in 103 aa overlap. The sequence contains a FT frameshift and therefore appears to be a pseudogene" FT CDS 183095..183220 FT /transl_table=11 FT /gene="HCM1.248" FT /product="putative transcriptional regulator (partial)" FT /note="HCM1.248, possible transcriptional regulator remant, FT len: 41 aa; similar to the N-termini of transcriptional FT regulators e.g. SW:LYSR_ECOLI (EMBL:J01614), lysR, FT Escherichia coli transcriptional activator of FT diaminopimelate decarboxylase (311 aa), fasta scores; E(): FT 1.3e-06, 53.5% identity in 43 aa overlap. The remainder of FT the CDS has been truncated" FT /db_xref="GOA:Q935H8" FT /db_xref="InterPro:IPR000847" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/TrEMBL:Q935H8" FT /protein_id="CAD09828.1" FT /translation="MKLRHLDIFYAVMTCGSLTRAAEVLHISQPAASKALKHAEH" FT repeat_region 183224..183238 FT /note="15 bp inverted repeat flanking IS10" FT repeat_region complement(183224..184538) FT /note="IS10" FT CDS complement(183230..184438) FT /transl_table=11 FT /gene="HCM1.249c" FT /product="transposase" FT /note="HCM1.249c, transposase, len: 402 aa; identical or FT highly similar to Tn10 transposases e.g. TR:AAD50242 FT (EMBL:AF162223) Shigella flexneri IS10-left transposase FT from Tn10 (402 aa), fasta scores; E(): 0, 100.0% identity FT in 402 aa overlap" FT /db_xref="GOA:Q7AQU3" FT /db_xref="InterPro:IPR002559" FT /db_xref="InterPro:IPR012337" FT /db_xref="UniProtKB/TrEMBL:Q7AQU3" FT /protein_id="CAD09829.1" FT /translation="MCELDILHDSLYQFCPELHLKRLNSLTLACHALLDCKTLTLTELG FT RNLPTKARTKHNIKRIDRLLGNRHLHKERLAVYRWHASFICSGNTMPIVLVDWSDIREQ FT KRLMVLRASVALHGRSVTLYEKAFPLSEQCSKKAHDQFLADLASILPSNTTPLIVSDAG FT FKVPWYKSVEKLGWYWLSRVRGKVQYADLGAENWKPISNLHDMSSSHSKTLGYKRLTKS FT NPISCQILLYKSRSKGRKNQRSTRTHCHHPSPKIYSASAKEPWILATNLPVEIRTPKQL FT VNIYSKRMQIEETFRDLKSPAYGLGLRHSRTSSSERFDIMLLIALMLQLTCWLAGVHAQ FT KQGWDKHFQANTVRNRNVLSTVRLGMEVLRHSGYTITREDSLVAATLLTQNLFTHGYVL FT GKL" FT CDS complement(184508..184858) FT /transl_table=11 FT /gene="HCM1.250c" FT /product="putative periplasmic protein" FT /note="HCM1.250c, possible periplasmic protein, len: 116 FT aa; unknown function, contains a probable N-terminal signal FT sequence" FT /db_xref="UniProtKB/TrEMBL:Q935H7" FT /protein_id="CAD09830.1" FT /translation="MKIKNIVLAGIISLVFSVHASDKQNIKRDPIPYLGYDAVTSNMCI FT DAGGLTDPVEMRKKATETLLMILHKQPGDKLSKQSEDTIEAFVTRTRSSSDDISKCQFS FT ADESPNDFYQNH" FT repeat_region complement(184524..184538) FT /note="15 bp inverted repeat flanking IS10" FT RBS complement(184865..184868) FT /note="possible RBS" FT CDS complement(185006..185620) FT /transl_table=11 FT /gene="HCM1.251c" FT /product="hypothetical protein" FT /note="HCM1.251c, hypothetical protein, len: 204 aa; FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q935H6" FT /protein_id="CAD09831.1" FT /translation="MAIDTDDTDPVDAEACEKYLAQLRELEAYRAYRTTAAIDWFFDQA FT TRAIHGELWLAACTTFLNGIETSLMVTMKLKASQAQPQAPTPLVDLSDMATLSNALLRR FT AHQAGMPVTLLAFPDEQDLLTKIADGAPKLPYAEIVRVRHNLCHGNILEHIITASDGMG FT EPVRLFTPECMRDLAQTLSAVSKVWIAGLHQYWCDNNLSMP" FT RBS complement(185628..185631) FT /note="possible RBS" FT CDS 185798..186232 FT /transl_table=11 FT /gene="mucA" FT /gene_synonym="HCM1.252" FT /product="putative DNA-repair modulator" FT /note="HCM1.252, mucA, probable DNA-repair modulator, len: FT 144 aa; similar to members of the ImpA/MucA/UmuD/LexA FT family e.g. SW:UMUD_SALTY (EMBL:M57431), umuD, Salmonella FT typhimurium protein involved in UV protection and SOS FT mutagenesis (139 aa), fasta scores; E(): 4.1e-21, 51.7% FT identity in 120 aa overlap. Contains Pfam match to entry FT PF00717 Peptidase_S24, Peptidase family S24" FT /db_xref="GOA:Q935H5" FT /db_xref="HSSP:1UMU" FT /db_xref="InterPro:IPR006197" FT /db_xref="InterPro:IPR011056" FT /db_xref="InterPro:IPR015927" FT /db_xref="InterPro:IPR019759" FT /db_xref="UniProtKB/TrEMBL:Q935H5" FT /protein_id="CAD09832.1" FT /translation="MSVFPERFASPPRDTTPFFSDLLSCGVMSPCAGHEDNELNLHDFV FT VRNRPATFFVRASGLSMVDAGINDGAILVVDRSLTAEHGSIVVALVDGEFTVKILQTFP FT KLMLMPSNPAFKPIPVNPDTLEIWGVVTFALNQFPHVHAR" FT misc_feature 185813..186169 FT /note="Pfam match to entry PF00717 Peptidase_S24, Peptidase FT family S24, score 135.40, E-value 1e-36" FT CDS 186216..187475 FT /transl_table=11 FT /gene="mucB" FT /gene_synonym="HCM1.253" FT /product="putative DNA-repair modulator" FT /note="HCM1.253, mucB, probable DNA-repair modulator, len: FT 419 aa; similar to members of the ImpB/MucB/SamB family FT e.g. SW:MUCB_ECOLI (EMBL:D90147), mucB, Escherichia coli FT protein involved in UV protection and SOS mutagenesis from FT plasmid IncN pKM101 (420 aa), fasta scores; E(): 0, 46.8% FT identity in 412 aa overlap. Contains Pfam match to entry FT PF00817 IMS, impB/mucB/samB family" FT /db_xref="GOA:Q935H4" FT /db_xref="InterPro:IPR001126" FT /db_xref="InterPro:IPR017963" FT /db_xref="UniProtKB/TrEMBL:Q935H4" FT /protein_id="CAD09833.1" FT /translation="MYMHVDINGAYAAFECAMDPKLAKSPLIIASNNDATIIAMNRLAK FT NTGLKRGMPIFKCRDLIEQHHIAVRSSNFTLYEDYSNRFHETLEGFAEDTDRYSVDESF FT MLLKNMDKIVDFEEYGCLIRRTLLHNLSLTCGIGVSTTKTLAKLCTYASKRWAATGGVV FT VLTDPFRIKKLLSLISTREIWGIGRKISERLTAYGIITACDFYDSDVRFLRKAFGVEME FT RTWRELHGESCFRLHESPPVRQQIIVSRSFGQRLNTFSKMHEAVSFFTGRAAEQLRNDG FT SWTRQITVFIQSSPFARAEARYSSCGIEPLTATQDTRDLVSAAGAILTRIYKPGIDYAK FT AGVMLSSMTDGTEQLSLFDERPARRGSEALMKVMDRFNKEHRGSLFLACEGIHQDFRGK FT QAMLSPRYTTRWNELLVVKA" FT misc_feature 186228..187265 FT /note="Pfam match to entry PF00817 IMS, impB/mucB/samB FT family, score 403.60, E-value 1.8e-117" FT CDS complement(187527..188336) FT /transl_table=11 FT /gene="HCM1.254c" FT /product="putative outer membrane protein" FT /note="HCM1.254c, possible outer membrane protein, len: 269 FT aa; shows weak similarity to TR:Q57333 (EMBL:Z11828), com1, FT Coxiella burnetii outer membrane protein precursor (252 FT aa), fasta scores; E(): 2e-09, 28.6% identity in 266 aa FT overlap. Also similar to TR:Q9X610 (EMBL:AF130422), bcfH, FT Salmonella typhimurium hypothetical protein (269 aa), fasta FT scores; E(): 6.3e-24, 31.4% identity in 258 aa overlap. FT Contains a probable N-terminal signal sequence" FT /db_xref="GOA:Q9L5K7" FT /db_xref="InterPro:IPR001853" FT /db_xref="InterPro:IPR012335" FT /db_xref="InterPro:IPR012336" FT /db_xref="UniProtKB/TrEMBL:Q9L5K7" FT /protein_id="CAD09834.1" FT /translation="MIKLNYLKPVASVLISAVIATAGSVYITSKYLKPDVPGNDEIGRV FT AASYLVKNPQYLLEAGKALEKENTNASLERIIPYAPALFETKETPNIGPDNAAVAVIEF FT FDYQCHFCMQVAPVVESVLSQSTDVKFFFKEFPIFAGSKPVSAMGAATGLHVYQTFGAE FT AYRKYHNNLMTSAYVFFNNQRAFTLNDLDMVVNKSGFNSSFGDREKSRYENVISGNMQL FT GEALGINGTPGFIIMNMQKPDAATTSFIPGAVDEATLKYAIQKARGG" FT CDS 188443..189054 FT /transl_table=11 FT /gene="HCM1.255" FT /product="putative lipoprotein" FT /note="HCM1.255, possible lipoprotein, len: 203 aa; unknown FT function, contains a possible N-terminal signal sequence FT (weak prediction) and an appropriately positioned PS00013 FT Prokaryotic membrane lipoprotein lipid attachment site" FT /db_xref="UniProtKB/TrEMBL:Q9L5K8" FT /protein_id="CAD09835.1" FT /translation="MLRQFFLLTATTFLCGCGYHFGNDVDAYDLLPRPVGSKKFEIVAP FT DDSIQSRMFAARFASGLTGKGFNISSHQPEYILRFSYSKTQENLQYSELPVTGITGYVI FT EKKTTRKDKHGQTETDYDYKPVSGIVGTETVSQRHFWRRLDVEVYPAGKNAQQVLKVSM FT QSNAPIPSDSVAYSAMIDALTGNLDAPLRSGNYVASVPWN" FT misc_feature 188461..188493 FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site" FT CDS complement(189113..189535) FT /transl_table=11 FT /gene="HCM1.256c" FT /product="putative membrane protein" FT /note="HCM1.256c, possible membrane protein, len: 140 aa; FT unknown function, contains hydrophobic, probable FT membrane-spanning regions" FT /db_xref="UniProtKB/TrEMBL:Q9L5K9" FT /protein_id="CAD09836.1" FT /translation="MSLWLSIVTRATGLPDKRYLNDPVILRYYQQKIQKAPYALVGWTL FT CFMATIGVSLGLDLSNQMLLLVLLILIFLMVVLQGRYQFMHPERCINAKFYQTVLDDAS FT VSDIQKAQFEYLFVTKVDELTIGDLYRLYDFNRGGR" FT CDS complement(189558..189950) FT /transl_table=11 FT /gene="HCM1.257c" FT /product="puatative periplasmic protein" FT /note="HCM1.257c, possible periplasmic protein, len: 130 FT aa; unknown function, contains a probable N-terminal signal FT sequence" FT /db_xref="UniProtKB/TrEMBL:Q935H3" FT /protein_id="CAD09837.1" FT /translation="MKSAILTTLMLVAVGSQPVFAAKCQFGACDADTVASSESLVSAAQ FT TDKDAVLKKLNDATSRSDVMSKRFESYLSNDRLKVNTDSTKKGPSNEIAKPRDELAPVR FT QLKAIRPELVQTPIFQPIVAFYERLA" FT CDS complement(189976..190725) FT /transl_table=11 FT /gene="HCM1.258c" FT /product="putative thiol:disulfide interchange protein" FT /note="HCM1.258c, probable thiol:disulfide interchange FT protein, len: 249 aa; similar to e.g. SW:DSBC_ERWCH FT (EMBL:X76687), dsbC, Erwinia chrysanthemi thiol:disulfide FT interchange protein precursor (238 aa), fasta scores; E(): FT 8.2e-26, 36.2% identity in 218 aa overlap. Contains a FT probable N-terminal signal sequence" FT /db_xref="HSSP:1EEJ" FT /db_xref="InterPro:IPR009094" FT /db_xref="InterPro:IPR012335" FT /db_xref="InterPro:IPR012336" FT /db_xref="InterPro:IPR018950" FT /db_xref="UniProtKB/TrEMBL:Q9L5L1" FT /protein_id="CAD09838.1" FT /translation="MNKTIKASLFLLASCTALSMNAQTANTDVLPDAALKKLREVGLSI FT EHIEPSPVKDIYTVISREGVSYVSKDGDYIFTGSLFHVNGKDVENTTEQAILKGVREFA FT TKTKSIEYKSANEKYRLAVFTDITCGFCQKLHQDLQSYLDAGISIKFLAFPRAGLNSVV FT AGNMAKIWCAAKPNDALDAAMSPTSTIPEGRPDEACLDTIKSHFQVASTIPLQGTPTMV FT TLSGKPQLFTGWMSPENLVTRMGAEQK" FT RBS complement(190731..190736) FT /note="possible RBS" FT RBS 190861..190864 FT /note="possible RBS" FT CDS 190873..191388 FT /transl_table=11 FT /gene="HCM1.259" FT /product="hypothetical protein" FT /note="HCM1.259, hypothetical protein, len: 171 aa; similar FT to CDS present in plasmid-borne type IV pilus biogenesis FT clusters e.g. TR:Q47073 (EMBL:Z68186), bfpH, Escherichia FT coli BfpH protein from plasmid pMAR2 (148 aa), fasta FT scores; E(): 6.6e-11, 37.0% identity in 135 aa overlap. FT Unlike BfpH, this CDS does not have a predicted N-terminal FT signal sequence. Also similar to TR:P71189 (EMBL:U67194), FT trbN, Enterobacter aerogenes protein possibly involved in FT mating-pair formation from plasmid R751 (211 aa), fasta FT scores; E(): 1.8e-08, 29.4% identity in 119 aa overlap and FT to SW:IAGB_SALTI (EMBL:X80892), iagB, Salmonella typhi FT invasion protein (160 aa), fasta scores; E(): 0.00031, FT 29.1% identity in 117 aa overlap. Contains Pfam match to FT entry PF01464 SLT, Transglycosylase SLT domain" FT /db_xref="InterPro:IPR008258" FT /db_xref="UniProtKB/TrEMBL:Q9L5L2" FT /protein_id="CAD09839.1" FT /translation="MFIPPVDDVKPIPVPVEIYTQCITDASRFFGIDAELVFTLFDNEG FT GKVGTFSRNKNGTYDIGPMQINSSNLPEIRDHFPSVTWRVLAYDACASFWVGTWWLYRK FT IVDRKGNVFEGIADYNSKTPKVRATYIFNFMIKYNRRIQRRNGMDELYQWTQPKPQYNG FT HIVKNLPE" FT misc_feature 190933..191298 FT /note="Pfam match to entry PF01464 SLT, Transglycosylase FT SLT domain, score 13.10, E-value 0.0061" FT CDS 191440..192003 FT /transl_table=11 FT /gene="HCM1.261" FT /product="hypothetical protein" FT /note="HCM1.261, hypothetical protein, len: 187 aa; unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935H2" FT /protein_id="CAD09840.1" FT /translation="MRLLENENVLRKRLTMLQSIYKFLFNLCSSPQLPKNKDVDGILSH FT EEITAGLWGPLPSIHVVLFLDFDGVVHKCQNESFERMHLIERLLDASPSMFIVISSSWR FT ECGSITYLKSLFRSPYRDRVIGATPSLYLPSGSIGVRAAECEDFVTRHKVKAFICLDDD FT ATLFLQSTRTCFVQIITPGLMKRI" FT CDS complement(192297..196286) FT /transl_table=11 FT /gene="HCM1.262" FT /product="putative membrane protein" FT /note="HCM1.262, probable membrane protein, len: 1329 aa; FT unknown function, contains hydrophobic, possible FT membrane-spanning regions. Contains {agg}5 motif which may FT be a site for slipped-strand mispairing" FT /db_xref="InterPro:IPR012931" FT /db_xref="UniProtKB/TrEMBL:Q935H1" FT /protein_id="CAD09841.1" FT /translation="MDYNIYTVGDIEFVWSALNGIALIFSQYTGVKAFLTTAAVLAGAS FT LFYKTWLWLLNPTKAEVPIFSWILGLILFSMAIVRVDVTIESVKSGEVRNVDGIPIFIA FT AMGTVTTNLSQGLLKDYKTAFDPLAPIDFAATTLDDDITLGPMIRFVKFLQWGGDSQGY FT CSAFPEPASGLGAMNVCATVQSLAYNCLKGTQNSSAKIAGKETIFNDIFSANIVDSMER FT INQAMKGSLKNASANIVGVNSSKSATCEEVWSTVKQVTSTPEARQTIALIGQTNGILAP FT DEAGGAASGASFTDVMASANGMYGKAIGAYDATLSLFIMNELRNGASKYKTPLGLASDM FT QLFEASLKRTNTMASQGQLWLQLSGAAIAFLEMFAYMVAPFALLMLLALGGNGVAAAAK FT YLQLILFVNMWPITAVMVNAYVKKVATADLDTWSTLNSQSNAVTWMGLPGLAETYSSYL FT SVASALYALIPVLTLFLMTQSIHPMMNAMKGVTPPAPVDSSHLTPKVWDAPNSGKSSFG FT DVNRTALTSTGQGFSGGGAMDSSNFRLGTWNAGSSIASSQGQGAAFTSSAMSAASNTFQ FT QAFNQMSEVGRTGQSGQQFTSNLQSLKSFTDQAGANIANSVGAKHGINSQQLAGVVSNL FT LLNGSLGLGGEEKLGKGGGGGLAQKVMDSLGIKAEGQVGSGITKSNSGNESLLTDLSKA FT ITTQLTENSGLTDQMTKAAAQINSDQFAQTNAFKEAATKMNQSTQTMAENLSTSLSTNA FT SANTGMTLDSRQAINLDRFSDSIRNKNFSDEDVRNFARKNGLDENAFMEKFNSYNDTFK FT ASTQLGSQLQRTDALVATTRDFSEQKIAIDTARGETAESNKQDLRETSSLLKGLVADFG FT GNAQQMLPITNQLDRITGDASGINTIAQAQDRTPEHVNTSSVMSADRVADVGQSMDAQA FT KAGLVQNQQNANQHVGGQTESGVTPYNVDKISKEDIQGIHQGNVNKSYSEENQNVLSSL FT EKNTPVVTNETVGRVQGAGVDVQHANQTFDQLQAGSGGKHATSGMGTISDKLNNMYGDN FT QIRGISGNLPNYFGRIANDPTKKPDDKRAELAAQAVFTYGASTMATGAEKEQLKADTQN FT ILSELSHYNVRWGMNDLQNIHEGFNMHNKASGSLDSVVRANLGEGGSGGGLVGQRTQTT FT TDLLVGNKIESNTERGVIGSTLLSGQESVARGLDVIGAKPVNDMLSGMGILTTPSSLAN FT DASNPQNMPSSLLGKVGNHLQMSDGVSEVTSRYKDMGGDGIKAYETASQNSERAIRQQL FT TDDPRFGPDKADAFVSFMKSNLNNTNEPYQSRIEKAKSWLNENKK" FT repeat_region complement(192497..192504) FT /note="(g)8" FT repeat_region complement(194320..194334) FT /note="(agg)5" FT CDS complement(196295..197710) FT /transl_table=11 FT /gene="HCM1.263c" FT /product="putative pilus-assembly protein" FT /note="HCM1.263c, possible pilus-assembly protein, len: 471 FT aa; similar to e.g. SW:TRH1_ECOLI (EMBL:M59763), traH, FT Escherichia coli TraH protein from the F-plasmid (458 aa), FT fasta scores; E(): 2.8e-09, 26.5% identity in 452 aa FT overlap. Contains a probable N-terminal signal sequence" FT /db_xref="InterPro:IPR010927" FT /db_xref="UniProtKB/TrEMBL:Q9L5L5" FT /protein_id="CAD09842.1" FT /translation="MRADFHVCAKKLLLSLAVCTAMIAPNAVADNAMRNIFNGMMTTTS FT PASFETATRTGVVGGSFSYRTTNVNTNLVSMSFPKASVGCNGIDVFLGSFSMINGDQLV FT QVARGIAQGAAIYAFNVAVSAICADCAATINDIQNKLQALNKFAKDSCNATYSFLTENV FT GPPSQFANAVSSGPASMLGTLNGLLPDFGSSMTKSPETVTSQVKAKDPEEFAEKFSGNL FT FYMSFMDIDKGSMNIGGVTELSGYRLAEQLMSLVGTVIINWDAKGEKAGMEVRPSTMTV FT SDFIMGPPAGGSIKMLKCSPAPDPASARKSQCLVMSEVTDGGFKGLKDTISDLLIQVQT FT KAISDVRISDDELRIISYIGIPTILDSLQTFDVPEGYAYIQDISAIAATSLVINMLRQV FT EAKISAMNIPSESLSGRRQDLTRLSENLTNQVKAAYELTRSQVGNSSDVISAWDDRRLK FT RKAFMESLRGTGN" FT CDS complement(197700..198746) FT /transl_table=11 FT /gene="HCM1.264c" FT /product="putative pilus-assembly protein" FT /note="HCM1.264c, possible pilus-assembly protein, len: 348 FT aa; shows weak similarity to e.g. SW:TRAF_ECOLI FT (EMBL:M20787), traF, Escherichia coli TraF protein from the FT F-plasmid (247 aa), fasta scores; E(): 2.1e-09, 24.5% FT identity in 212 aa overlap. Contains a probable N-terminal FT signal sequence" FT /db_xref="InterPro:IPR012336" FT /db_xref="InterPro:IPR014111" FT /db_xref="UniProtKB/TrEMBL:Q9L5L6" FT /protein_id="CAD09843.1" FT /translation="MTRLTLIPSKMLVLLSLFITGVHANEEQALIKDTPFVSGQAFKKG FT FFWYDDPTRKTEEEITETKPPVASSTQPEQEEKIELNSKWLKDNMPQLLTKAMDNPTPE FT NLSRFYTAQRLMLDIGTRFSDKSKDYFLKNPMMSEKRRQPVEKVALDAHRTVVEKNQQS FT VMKDIFTKSGLFFFFQSTCQFCHEESQILQFMENYYSVDILPVSMDGRPLQNGLFQDFS FT VPNAQIIDQFKIREVPTIFLVSKDGSSAQRISEGMITAEELKNTIILAAKGMKLIDDAS FT FQSTLDIKRQYTIGEDGVITVNKSEMDSDPFLLQRIMDKKLEGYDMPTADPVNYLNVGG FT SLGGAYAR" FT RBS complement(197715..197721) FT /note="possible RBS" FT RBS complement(198755..198759) FT /note="possible RBS" FT CDS complement(199358..199870) FT /transl_table=11 FT /gene="HCM1.266c" FT /product="hypothetical protein" FT /note="HCM1.266c, hypothetical protein, len: 170 aa: FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q9L5L8" FT /protein_id="CAD09844.1" FT /translation="MAKVDQTKANMLLSATKTMSLGANKNSIRILYGNHVAENIDFRSE FT PQQNFKKGIRGWSRRTDNRRAFSAVIDVAVNYFGFDPIHPESSFRNIDFNRIMSVLHNL FT GYFVCAPEVNKIIEILTSMKEIEELETCAKCKRPYIVPYTNDTHCPRCRLSSTSSAIAR FT YSQEELD" FT CDS complement(199873..200673) FT /transl_table=11 FT /gene="HCM1.268c" FT /product="hypothetical protein" FT /note="HCM1.268c, hypothetical protein, len: 266 aa: FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q9L5L9" FT /protein_id="CAD09845.1" FT /translation="MSESDNITRNLLGKLLRTEISIIRSYRAFLMLLPLHGSSKYQTGS FT PLLQRRLFGNGFGAMIDNAFEVETRPGSFLVPRSLSKEISWDKFFVAVVDGDTNVIREY FT DSEDTDFGIYNEGEKVTLLSGQEEFYNPRKIQQLRSKCVDIQNDYLMQVFFMSMLAPEF FT VSIFFGLKPATVEAIKDVGMSSLKLINDVVLFPRTIPFTPGLGDDSATLKSKVFAWAYE FT ISADIRLGKISDDLMELLRYDTMFTCHRQDVFNTLANKVLLKDY" FT RBS complement(199880..199884) FT /note="possible RBS" FT RBS complement(200684..200688) FT /note="possible RBS" FT repeat_region 201039..201103 FT /note="inverted repeat; 50/64 (78%) matches, 2 gaps" FT repeat_region complement(201107..201171) FT /note="inverted repeat; 50/64 (78%) matches, 2 gaps" FT RBS 201421..201426 FT /note="possible RBS" FT CDS 201431..201916 FT /transl_table=11 FT /gene="HCM1.269" FT /product="hypothetical protein" FT /note="HCM1.269, hypothetical protein, len: 161 aa: unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5M0" FT /protein_id="CAD09846.1" FT /translation="MSKSKLLKSLEISRTLLRSQIDVLREEAEELITNYWIEWKERNHI FT ERNLPRDSKTLKKEYLGSYAPKVELIGNARKVTITWHQFSPYKNRPPSHMSKRISPMKS FT GKYTKSCFVNHASWEYEMIEKTEGLLEPYRELLEFYHAAYIELGRKVRQYSKSEVAQ" FT CDS 201913..202635 FT /transl_table=11 FT /gene="HCM1.270" FT /product="hypothetical protein" FT /note="HCM1.270, hypothetical protein, len: 240 aa: unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5M1" FT /protein_id="CAD09847.1" FT /translation="MTDVTMNESEHKVPDVNTRSPHASDNSRRVVQSKNEHYGMATVTI FT TPGTPDFNRFLTARNRSVIRGFDDVSIAISSLFRTVNAVKHPELVQAIQDWFNELHEEN FT NLMKNNLERHIATIHIDESDPFFSSTEFSPFRFEPVQLNFNNQNTMRFYKHIFEMNNLL FT TQMHKFNSLGQLPVSDYNVMAHNIIRSLNMYIERVKKTLNVSRRAKGAYSPDEFIEKVK FT QYKSVQAYIAAELSGKRR" FT RBS 202633..202638 FT /note="possible RBS" FT CDS 202646..205681 FT /transl_table=11 FT /gene="HCM1.271" FT /product="hypothetical protein" FT /note="HCM1.271, hypothetical protein, len: 1011 aa: FT unknown function" FT /db_xref="GOA:Q935H0" FT /db_xref="InterPro:IPR003607" FT /db_xref="InterPro:IPR011119" FT /db_xref="UniProtKB/TrEMBL:Q935H0" FT /protein_id="CAD09848.1" FT /translation="MNFRALFLSMQRVFGIFSRRENDVSELMMKDAANFSPFAQIIGEQ FT KYTVPDHPNPEVLKFIEYPTRPAGIQTFNEQSILSLYRDKLHSISMMLAISDGDIREDA FT YTFTNLVLKPLIEYIRWIHLLPASENHHHNGIGGLLSHSLEVAMISLKNANHSELRPIG FT YQDEEVVRRKVYLYAAFICGLVHDAGKVYDLDIVSLNLSETLTWAPSSQSLLDWARENN FT VVEYEIHWRKRIHNQHNIWSSVFLERILDPVCMSFLDRVKKERVYAKMVTALNVYNDGN FT DFLSKCVRTSDYYSTGTDLNVLRDPIMGLRSNDAAARAIGTIKHNFTSININNYKTKPM FT HIIIVNGEVYLNENAFLDFVLSDFAAHKFNFPQGDAGKTVLVESLVQRGYVEPYDDERV FT VHYFIPGTYSENEIASIFRNGIGKLEFYNLLKLRWIGLIFDSYKIPDSVPGLFSVNANK FT DFIYIDEQKTVTEYRRPVPGRESVTRVTDTVNDAIENTPQYGLQLVNGPDADSNNIISS FT ENTESITDSLEESGADISNEIFETQVVTAIDTAETVNADEPEQVEEHDDRSQIHLVEQL FT HEMLLSAPLPHHAVINIDSVPYLDLDAAIALIPGIDEAAFCNGPFFQLTYRDGSLDGMW FT IVRDVNNLRLIQLGDNCAGMQVSTSEPRNTSSLKSLFDTSMYQPLDIPEAPSVNEAASP FT PQTPLELPQPRLNAPVAEEASSVAEQTNAHSEPDSVIATEYEQYGHLLEETLDSDGEAY FT SDLIASDSTEAEYPATDPQSSDFAQLPRETALSVAPGDLDYSEGAIKPPAPDATGKETI FT LTSPEPAEDVRETVAAVEKASHLSPALARLFAVSTHAEKKHEKTQEPSPVKEVKNPTSS FT TTVKAPISIEPPGAEEKEAVEEFTLLNDGEVTELEYVEIATMLHQILTKLSGSFKRKRK FT NRFMVLTQNTFYLTQSCIEKYGTQLNAPELFNQLPQYQVTSGAVVNTKCIAFNIPTLVA FT ASDRAKVDIELIINKLKEVGNL" FT CDS 205681..207765 FT /transl_table=11 FT /gene="HCM1.272" FT /product="putative membrane protein" FT /note="HCM1.272, possible membrane protein, len: 694 aa: FT unknown function. Contains hydrophobic, possible FT membrane-spanning regions. Contains PS00017 ATP/GTP-binding FT site motif A (P-loop)" FT /db_xref="UniProtKB/TrEMBL:Q935G9" FT /protein_id="CAD09849.1" FT /translation="MTKSKRTNLHAQENFYRPILEYRSASVLLICAVIMLVMGFRSDGV FT NIAPIILYTAVFLLLVCLYRCKTAHPYLMAHWRVFQRQIMFISLKSLRTINKSNFFSNE FT RKYRQLVQEYKKNNRPVPDRKTYFCNGFEWGPEHADRAYQIANLSSDKREIALPFVLSP FT IARHFETMARSMGGNNAIFAVDRRAPIFVTEDNWFGHTLITGNVGTGKTVLQRLLSISM FT LHLGHVIVVIDPKNDAEWRQSLMDEASELGLPFYKFHPAQPSSSVCIDVCNAYTNVSDL FT TSRLLSLVSVPGEVNPFVQYAEALISTVITGLSYTDKKPSIYLIHKNMKSHMSVVNLTI FT KVMECCFARHYGPDVWMEKVKYASNDTLQVRFKRLTEWFNAHFLNYEGAEPIEWIDTVG FT RLVDYSMSDPEHMSKMTAGIMPLFSRLTEQPLNELLSPSPNTLTSREIVTSDGMFSTGG FT VLYISLDGLSNPESARAISQLIMSDLTSCAGSRYNADDGDMSSHSRISIFVDEAHSAIN FT NSMINLLAQGRAAQIALFICTQTISDFIAAANAETANRITGLCNNYISLRVNDTPTQTL FT VVENFGKSPISTNMVTYTTGSETTLPHNNFSGSISERKQTTLEESIPKELLGQVPKFHI FT VARLQDGRKVVGQIPIAVSEKAMKPNTTLLEMFLKPAGKVTLRQNVGLSYLNKYLRKLH FT " FT misc_feature 206293..206316 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)" FT RBS 207749..207754 FT /note="possible RBS" FT CDS 207762..208868 FT /transl_table=11 FT /gene="HCM1.273" FT /product="hypothetical protein" FT /note="HCM1.273, hypothetical protein, len: 368 aa: unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935G8" FT /protein_id="CAD09850.1" FT /translation="MMDEQITLTQNQIFSASLKVSKSRSLVKRRMQSLGLKFTESQDVR FT NRLAGIEKGALKCVGQFCHDNDAESLSAMAIILSELFLLQGELSTSNEYGDHETSYWTV FT AQGPCDEWVQSLLASENGRRTFNSFRITFDNSEERRSLVEKNAKMLGSYLLPYFVNFTN FT AASAFITLPNSITFKQVQRNKPLIHPETTLSHILTIEDSAFLSRIKFKLISAIDRLPDP FT SGQYANMFNHIMDRALLTHLNREQIDSPCVCKKVISTYADTMLTLPIFNTTITGKYRHW FT TPWGINFVEFSRQAAKEKSCVYVPEPGQIHWKSPEHKELAEYSLINQIIPQQYHWLLGV FT PTIWRSHYRDHSKRLDLFKEWRDANGCG" FT RBS 208843..208847 FT /note="possible RBS" FT CDS 208855..209517 FT /transl_table=11 FT /gene="HCM1.275" FT /product="putative membrane protein" FT /note="HCM1.275, possible membrane protein, len: 220 aa: FT unknown function. Contains hydrophobic, possible FT membrane-spanning regions" FT /db_xref="UniProtKB/TrEMBL:Q9L5M5" FT /protein_id="CAD09851.1" FT /translation="MAADNSARAIFIRGLLLLGMMLYLIYSLGFQNTDELKQQITQEVN FT ASRSLISNDRWLSVIANSEATLSTLINDYKLIDYLNTILIPDTSTPARGMNYVAEKMTS FT VNYTVAKNLPLLIYQSIFRWNLILGWLILFSPYLIAMLADGMYQWKLKRYVFGNVTVQF FT YRIWFRAFWIIGALTFIYLSMPNMSLFNNIAQLFPPVALLILGIALNRLWSNFQKLM" FT CDS 209530..210711 FT /transl_table=11 FT /gene="HCM1.276" FT /product="putative peptidase" FT /note="HCM1.276, possible peptidase, len: 393 aa; shows FT weak similarity to many putative peptidases (signal FT peptidase-like) e.g. SW:PFAP_LEPBO (EMBL:L27482), pfaP, FT Leptospira borgpetersenii putative peptidase which was FT detected by reaction to mAbs raised against a periplasmic FT flagaella-associated protein (204 aa), fasta scores; E(): FT 5.3e-09, 33.5% identity in 179 aa overlap. Contains Pfam FT match to entry PF01343 Peptidase_U7, Peptidase family U7. FT Contains one hydrophobic, possible membrane-spanning region FT near the N-terminus. Alternatively, assuming codon 27 as FT the true start codon, this region could represent an FT N-terminal signal sequence" FT /db_xref="GOA:Q9L5M6" FT /db_xref="InterPro:IPR002142" FT /db_xref="UniProtKB/TrEMBL:Q9L5M6" FT /protein_id="CAD09852.1" FT /translation="MFKRNNKKSPANIKESLDENADRFYKMFRIHTTSKVVISLLALAA FT AGVSAFNIYDKYQESEGRMDHIAVVRISGEMGTGSEVGDGSVIATALAKAYNNPHAKAV FT IIEAESGGGGPSDAIIIYRQINALRSHQQKIERVSHAESTSKPRNTSDHSASRSQADSN FT AELSKRNTLDVLSAGSGHFISDMENSYKPIIVSVKGICASACYYAVSPADAIYADSSAL FT TGSIGVRMDHWNLSRVMDTVGVKNEPLTAGEFKDALDPYHPLSDATRDFMQKQILDAMH FT EQFIADVEQGRGKKLLSRPEADAVALYSGRVWTTQQAIRYGLIDGDLTPVEVRSRLSQM FT YSTTIFKTYNEPQRSLRSALGMLMSLSTNVETLAGTTSRILDSVQATSYPTVR" FT misc_feature 210082..210555 FT /note="Pfam match to entry PF01343 Peptidase_U7, Peptidase FT family U7, score 104.50, E-value 2.1e-27" FT CDS 210728..211441 FT /transl_table=11 FT /gene="HCM1.277" FT /product="putative periplasmic protein" FT /note="HCM1.277, possible periplasmic protein, len: 237 aa; FT unknown function, similar at the N-terminus to TR:Q9X2X2 FT (EMBL:AF065404), pXO1-01, Bacillus anthracis hypothetical FT protein from virulence plasmid pX01 (167 aa), fasta scores; FT E(): 2.9e-09, 28.1% identity in 146 aa overlap. Contains a FT possible N-terminal signal sequence" FT /db_xref="InterPro:IPR011528" FT /db_xref="UniProtKB/TrEMBL:Q935G7" FT /protein_id="CAD09853.1" FT /translation="MVWRVIGISIIVLVLIVLYCLMGFVSSAIAERRTARQIEIYLPDD FT AEGLLSDLTLPVNATGTTQIDHVLIASHGLYVIEQKNYAGKLYGKLEESHWRKWKSSGT FT LKLQNPFRQNYGHIRAIQSTLRASELECINVVIINGPCKFEGEKPDWLCMGMEEFVRKV FT TERRQLNVFKPEAVSFIRGELKLKRKPPGLYTDLNHIHNVTTRYKTTMRLEQRITYNLL FT RFSRLILSKMFRSAK" FT CDS complement(211468..211824) FT /transl_table=11 FT /gene="HCM1.278c" FT /product="hypothetical protein" FT /note="HCM1.278c, hypothetical protein, len: 118 aa: FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q9L5M8" FT /protein_id="CAD09854.1" FT /translation="MTTANVTTTTYRSDDIVPFRRPQGDLDNRYMPQAYALVRSWASKP FT AEYGAGVLATYRQPVVNLGYKIKGTRVVLILVPIECEPVGVKMTDAALWPSLSIGEAMR FT IMQEAWQNIPELNP" FT RBS complement(211832..211836) FT /note="possible RBS" FT CDS complement(211911..212225) FT /transl_table=11 FT /gene="HCM1.279c" FT /product="putative membrane protein" FT /note="HCM1.279c, possible membrane protein, len: 104 aa: FT unknown function. Contains hydrophobic, possible FT membrane-spanning region" FT /db_xref="UniProtKB/TrEMBL:Q935G6" FT /protein_id="CAD09855.1" FT /translation="MNTFLYVLVGWIIVLYLVNKVREKYSKPKTVNILVKRNGVYQEVE FT AVVMPRSHNSDVGTGKTGNEAAPQWLNKEDDISELEYYSGGSLLKAARDFEAQQMEQKF FT " FT RBS complement(212230..212236) FT /note="possible RBS" FT CDS complement(212540..212776) FT /transl_table=11 FT /gene="HCM1.279ac" FT /product="putative membrane protein" FT /note="HCM1.279ac, possible membrane protein, len: 78 aa: FT unknown function. Contains hydrophobic, possible FT membrane-spanning region" FT /db_xref="UniProtKB/TrEMBL:Q935G5" FT /protein_id="CAD09856.1" FT /translation="MMLLNIALILYVAVCLYLCLRNKKALYRFQGGGRQFTQSSKSGAN FT TGESGFFLISGYSDTGVGGDSGDAGGGCGGGGD" FT RBS complement(212781..212785) FT /note="possible RBS" FT CDS complement(213149..213385) FT /transl_table=11 FT /gene="HCM1.279bc" FT /product="hypothetical protein" FT /note="HCM1.279bc, hypothetical protein, len: 78 aa; FT similar to hypothetical proteins e.g. SW:YKFF_ECOLI FT (EMBL:AE000133), ykfF, Escherichia coli hypothetical FT protein (79 aa), fasta scores; E(): 1.3e-07, 37.3% identity FT in 67 aa overlap" FT /db_xref="InterPro:IPR009253" FT /db_xref="UniProtKB/Swiss-Prot:Q9L5N1" FT /protein_id="CAD09857.1" FT /translation="MSDLFSSESPVTLAQARTVAAGYQNVFIENLQPAGHFQIVIRDHR FT DHDSQLVWRNWNYESGANDALNSYLQSHGLKAS" FT RBS complement(213393..213397) FT /note="possible RBS" FT CDS complement(213431..213976) FT /transl_table=11 FT /gene="HCM1.280c" FT /product="hypothetical protein" FT /note="HCM1.280c, hypothetical protein, len: 181 aa: FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q9L5N2" FT /protein_id="CAD09858.1" FT /translation="MKTLNIQVNDIAAISALGGSMLADIIAAQYKVIDDTKDASEMAMP FT CIAYGQIPANIGPGVFINRVYSMDSQSLSASQRYELFNGLATQAFTFFFQSGWYGAFRV FT VSFRDNGPAGLLNIGIVHDKVLNEFCDDFPRANVSETGFNCGMTFDQIRMFISDLAYQM FT PLYNNQDHFVKLAKHLAA" FT CDS complement(214057..214494) FT /transl_table=11 FT /gene="HCM1.281c" FT /product="hypothetical protein" FT /note="HCM1.281c, hypothetical protein, len: 145 aa: FT unknown function" FT /db_xref="UniProtKB/TrEMBL:Q9L5N3" FT /protein_id="CAD09859.1" FT /translation="MYKYDRNRQTFNLINALQPVYRNNGGGLFEFDRRKQHETADLIFE FT ALTFSPTPELELAKFVRLKSVRRIAQFDDGEVRYGVHVELDEAVNINSFRIFKDDNTGG FT FDFYLFSVLGNNAELVQINLDASNIHLQDIFERSTGLCLSY" FT RBS complement(214504..214507) FT /note="possible RBS" FT CDS 214547..214870 FT /transl_table=11 FT /gene="HCM1.282" FT /product="hypothetical protein" FT /note="HCM1.282, hypothetical protein, len: 107 aa: unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5N4" FT /protein_id="CAD09860.1" FT /translation="MPVGDQLFALQRGETLLGQYRQYGNVGYTVVTPCVKQHLPGASVV FT TAHFHFLFRSMAGGNSLLIETFILGSRALLQCRINKGVKRVRTIRCISQIGFHNTSYVF FT GII" FT CDS complement(214976..215161) FT /transl_table=11 FT /gene="HCM1.283c" FT /product="hypothetical protein" FT /note="HCM1.283c, hypothetical protein, len: 61 aa: unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q935G4" FT /protein_id="CAD09861.1" FT /translation="MNTERSNGTTLWIEHGFIILKDSVLALIMLKRLISASECVATRIC FT WSGKKLPNNAPPMEAS" FT CDS complement(215158..215439) FT /transl_table=11 FT /gene="HCM1.284c" FT /product="hypothetical protein" FT /note="HCM1.284c, hypothetical protein, len: 93 aa: unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5N7" FT /protein_id="CAD09862.1" FT /translation="MKNTAINISTKKPLQTVKDPVTRVSIHCTAKDEKGADVEVNILDL FT EQHHTTNEIKLTFGGSPSQALTMLSRVMVVLQQQAAEELQRNSCSRLQ" FT RBS complement(215450..215455) FT /note="possible RBS" FT CDS complement(215505..216710) FT /transl_table=11 FT /gene="HCM1.286c" FT /product="putative DNA-binding protein" FT /note="HCM1.286c, possible DNA-binding protein, len: 401 FT aa: unknown function, contains probable helix-turn-helix FT motif at aa 169-190 (Score 1483, +4.24 SD). Similar to FT HCM1.58c, possible DNA-binding protein (385 aa), fasta FT scores; E(): 3e-21, 31.6% identity in 297 aa overlap and FT HCM.63c, hypothetical protein (358 aa), fasta scores; E(): FT 7.1e-13, 31.9% identity in 191 aa overlap" FT /db_xref="GOA:Q935G3" FT /db_xref="UniProtKB/TrEMBL:Q935G3" FT /protein_id="CAD09863.1" FT /translation="MSTVENDVKTANNDISLRTYLERTGNGARKSNGLVINPAVVEEEE FT GFNTRTAGIGESYYSLPDVVAHLNSLKESYKIDPLSVQAIVVQILNGRPVLRQGACRIR FT AVAMANIELADEGRELITLIRCEEFRGSRASAEQFTLDGNSNLALSVVAEALSIKRMVE FT DAEEPKTFAELAKRRGKTEQHLRQMVRVLDLPEALQAMLVKGEVSMYVALDEYLYSGDE FT AVNNITKAIDVYGKATAKTLKFVKAGNIDAAMKPKAAIVPDANATPPETTVTEQTSGEG FT TNDETTPPQLVDGSAGTNPEPTPERTPAPQMKDPVKTPEPKAVSVSSVLNKKTVTTIAD FT TAIPLFSRIAEEAKQRAAKNLSDDTYTLVLTNDEMNAICEAHGDLTQYLRKHAEKQNKG FT QA" FT RBS complement(216718..216722) FT /note="possible RBS" FT CDS complement(216827..217223) FT /pseudo FT /transl_table=11 FT /gene="HCM1.287c" FT /product="hypothetical protein (pseudogene)" FT /note="HCM1.287c, possible pseudogene, len: 397 bp; unknown FT function, may change frame (from frame 5 to frame 6) at FT {g}8, suggesting that this CDS is subject to slipped-strand FT mispairing" FT repeat_region complement(216982..216989) FT /note="(g)8" FT CDS 217313..217504 FT /transl_table=11 FT /gene="HCM1.288" FT /product="hypothetical protein" FT /note="HCM1.288 hypothetical protein, len: 63 aa: unknown FT function" FT /db_xref="UniProtKB/TrEMBL:Q9L5P0" FT /protein_id="CAD09865.1" FT /translation="MSSTDRYSLHGQPGTEIAPCRRKAENLKFDKAAGSYFLHVQTNKG FT LADDRKEKRVSPTGETLF" FT CDS complement(217566..217724) FT /transl_table=11 FT /gene="HCM1.290c" FT /product="putative stable plasmid inheritance protein" FT /note="HCM1.290c, probable stable plasmid inheritance FT protein, len: 52 aa; similar to many proteins implicated in FT killing of plasmid-free cells e.g. SW:HOK_ECOLI FT (EMBL:X05813), hok, Escherichia coli HoK protein from FT plasmid IncFII R1 (52 aa), fasta scores; E(): 5e-13, 73.1% FT identity in 52 aa overlap. Contains Pfam match to entry FT PF01848 HOK_GEF, Hok/gef family and PS00556 Hok/gef family FT cell toxic proteins signature. Contains hydrophobic, FT possible membrane-spanning region" FT /db_xref="GOA:Q935G2" FT /db_xref="InterPro:IPR000021" FT /db_xref="InterPro:IPR018084" FT /db_xref="UniProtKB/TrEMBL:Q935G2" FT /protein_id="CAD09866.1" FT /translation="MKLPNQPVVLCVLIVCLTLLIFTWLTRNSLCELRLKDGTREVSAV FT MDYESGK" FT misc_feature complement(217569..217718) FT /note="Pfam match to entry PF01848 HOK_GEF, Hok/gef family, FT score 89.60, E-value 6.2e-23" FT misc_feature complement(217632..217691) FT /note="PS00556 Hok/gef family cell toxic proteins FT signature" FT RBS complement(217734..217739) FT /note="possible RBS" XX SQ Sequence 218160 BP; 57942 A; 50902 C; 52901 G; 56415 T; 0 other; ggcgattttc tccagttcct catcgaggcg ggtatacgtc agcctcctga ttttcaagat 60 ttccttgtga agccagcgtt tgataaaggg attgccggaa agcagtacca ggtctgcatc 120 ctccacttca tcaaaaagcc agacgggttt tgccggagta aggcggtaga gccaggggcg 180 ggaaaactcc cccgttgcaa tcagaaacca gacaaccatg ccaagtgcga actcgatgac 240 cagcatcagg gtaaactgaa tatcccggac gtcaggctct ccggtaaagc tcattaggcg 300 gtcgccagtt gccagacgct gaataataca gaccagcatc agcagagcca gtaacagcgc 360 catgagcagc ccgccgttca cttcaaaagt agctttctgg acgcgatcag gcggcacctg 420 cttacggtag cggccgacca catcaccaat cattaccctg atggctatgc gttcttcatc 480 gaccgttgtt tcggtaaatc cggacgggcc cgtttctgtt tgattcatgt accctctcct 540 ctctctgaaa aataatggta agacgcaagc tgatcatacc aggtgagcag gagtggtttt 600 gtcggttaaa ggctggaaaa aaacggttaa aaaaagaggg aaatgacagc aagaaggtgg 660 gatgcagtaa gcggctttgg ttccctccgg ttctgtgggg aggaaacggc cagaacagca 720 gaccgatacg atgggcgggc gctattttgt atccagaatt cgtgcctttt cttcccgcgt 780 cgccagtcgg gcacttccgg aacggtcgcg gatcagcagt ggcttttcct ttttccaacc 840 agtgatagcc gtttccccga aacgacgcgg tgcattgcca ttccagctgg caatcacgtg 900 attatcgtgt acttccttga tgacgacaga atgaagagtc accgtcttaa tggtggtgtt 960 tcccattttg gtccgggaga gtgaccagac ggtcatcccc acctccagct gactgagttt 1020 catctttact ccggtaatat cgggatacat cattaaacga cgtggagacg taggttagca 1080 taagcactca cagcggatac tgccgccaga taacagggtg aggtatccgc catgagcagt 1140 ctttacggct ggcgttattc ggccagggcg cgggtaatag acgcacgctg acgctggcgc 1200 tcagccttac gctggctgcg gcgatatagc ggcttcgcgg cagcgtagcg acaatcttcc 1260 gggtggtacc agcaacagcc gcagggctca ggctggggtt ttccggcaag tccgaatggt 1320 ttcataatgt caccttttaa atggaataat gttcaggtcc cgtccatcag gccacgggtt 1380 cattaatgaa gcggcgttgc ataaacaggt acagataacc ctctggcgag aacatacaaa 1440 gattctcggt aatacaggca tcgaggtact tcgtgtcgcc aaggagtcgc ttaatgacag 1500 ccagctggtt agccgcagac tgaatcagcg gatagccatt cacggcacga tgaatacctg 1560 agtggaataa cgaacgagcc tttccaatct tttcccgggt tgcgtccatt tccatatcga 1620 taacagactg acgcgcaaca ttaatagcat tgccggataa ctccgcgaag ctaaccagag 1680 gcttattcat aaaaaactcc ttccaggtat gtgagcttat tatatcaata cggactttgc 1740 cccaaacaac ccgactcgaa atattttgga aattactcta ataactaaaa atggcacccg 1800 gaaaatagaa tgaatttatt ttaagcttgc cgaacatggc tggcggcgga attaaatttg 1860 ggtaatgact ccaacttatt gatagtgttt tatgttcaga taatgcccga tgactttgtc 1920 atgcagctcc accgattttg agaacgacag cgacttccgt cccagccgtg ccaggtgctg 1980 cctcagattc aggttatgcc gctcaattcg ctgcgtatat cgcttgctga ttacgtgcag 2040 ctttcccttc aggcgggatt catacagcgg ccagccatcc gtcatccata tcaccacgtc 2100 aaagggtgac agcaggctca taagacgccc cagcgtcgcc atcgtgcgtt caccgaatac 2160 gtgcgcaaca accgtcttcc ggagcctgtc atacgcgtaa aacagccagc gctggcgcga 2220 tttagcgcag acgatgacgt cactgcccgg ctgtatgcgc gaggttaccg actgcggcct 2280 gagtttttta aatgacgtaa aatcgtgttg aggccaacgc ccataatgcg ggcggttgcc 2340 cggcatccaa cgccattcat ggccatatca atgattttct ggtgcgtacc gggttgagaa 2400 gcggtgtaag tgaactgcag ttgccatgtt ttacggcagt gagagcagag atagcgctga 2460 tgtccggcgg tgcttttgcc gttacgcacc accccgtcag tagctgaaca ggagggacag 2520 ctgatagaaa cagaagccac tggagcacct caaaaacacc atcatacact aaatcagtaa 2580 gttggcagca tcaccgaaaa taaaatagag agagttttca atccgcatga ctttaaaaaa 2640 gacaattttt agaaataagc cggataaaaa aatagcttta tccggcactc atattacaac 2700 cagttcttcc gcttaaagta cagatacggt gccaggcccg cgaggatcat aaagataatc 2760 gcggcagggt agccgaacct ccacttcagt tctggcataa actcaaagtt catgccatag 2820 ctggaagcaa cgagcgtcgg cggcaggaat accacggata ccaccgagaa gattttgatg 2880 atgcggttct gctcgatgtt gataaaaccc attgccgcct gcatcaggaa gttcaccttc 2940 tggaacaggg attcgttatg cggcagcagg gattcgatat ctcgcaggat ttcacgcgcc 3000 tgctccagtt gcccacccgg taaacgcgct ttacgcacca ggaagttgag cgcgcgctgg 3060 gtatccatca gacacaggcg aactttccag ccgatatctt ccagttccgc cagagtggag 3120 agcgcctcgt cgtactcatc gccctgatgc ccttccataa tcacccggct caactgctcc 3180 aggtcgctat agatattttc aatttcatct gccaactgtt cgattttggt ttcgaacaga 3240 tccagcagca actcgtaggc gttaccgtct accatcgact ggctacgggc acgcatacga 3300 tacagacgaa aagcgggcag ttcacgctca cgcagagtaa acagacgacc atcacggatg 3360 gtaaatgcca cagtggagtt accggcgtga tcttccgcat cttcaaagaa gaagaaggag 3420 tgaatatgca ggccgtcgtc gtcttcaaag aaacgtgccg atgcttcgat gtcttccagt 3480 tccgggcggg ttgccaggct ctggccaagt tcagattgta agcgcagtcg ctcgtcgtcg 3540 tccggttcga caagatcaat ccatactgca tttacaaggg gttgtgactc ttcgacttcc 3600 agccgggtca gtcggttatt ttccagttga aatgcgctca gcatgaccgg gactcccaat 3660 gcttaaaata tcggacagtt cggtgggcac acagaaacaa attgggtttc agaccattaa 3720 acagcctgac tcagcgcgac gggaaaaatt gaggtcgctg acaaccgcta aggctatcag 3780 caaaaaggga tagccttagg agttgatcct ggatgacagg atagtgagcc agtatctact 3840 gggtgtgtcc aaggcgaatg tcctcttaga gtgatcgtgc gcgcatgtta cgccagcaaa 3900 attttgccgt caacacgcaa cagaacacca cagaacaata gttgaacttc gcgctttttg 3960 gtactcgtca aggtcgctaa caggataaaa aaatcccaca tccaggacct ataatggcgc 4020 atcagctact cattggtaaa ggaatgatca ccttgaatct caaacggatt tttctcgccc 4080 tcaccttact tcccttgttt gctgttgccg ctgatgattg cgcactctca gatccgacgc 4140 tgaccgtaca ggcgtatacc gttaatcctc aaacagagcg ggtgaaaatg tactggcaaa 4200 aagccaatgg cgaagcgtgg ggaacgttac atgctctgct ggcggatatt aatagtcagg 4260 gtcaggtgca gatggcgatg aacggcggca tcttaaattt gacggttttt gatataaaat 4320 atagaaagaa ggaggttttc tgaatacctc cttcactggc gctcagttcg agaatacgtt 4380 aacgctgtac cgtttaccga gcacctcggc agtggtatcg acaattttct gaatatcatc 4440 ggcaatcgcg ggtttactga atgcgacggt gtgcagttca ccagcctgtt ccgccgtcgc 4500 accatcatga aagcggctgg catcgtaaag ctggacccgg agtgtccggg tataatcgac 4560 atggcccatt attcctctcc tgttcagtca ggcgctatac gcgttaataa tcactttctt 4620 ccggttgcgg ctgggtgaca aactggtact tcaccccatt agggacgcca acggcttttg 4680 ctacagattc acacagcagc gacaggtcat tcagagtcat cggatattcg atatcgacgg 4740 aatataaggc cccggcgttc tcggcctctt cgatattttt atactgggca ctgaaaatgg 4800 ctatggtaga gatttcaagg ttatgcatga gtcagtcctt gttaataaaa aagaagccac 4860 cgtaaggtgg ctgaataaag gttaatggac ctggctggcc tttttttccg cgttcttgtt 4920 gtaatcaacg cgggcaataa cgacggcagc ggccaggagt gcagcgagac cgccgtagaa 4980 tactggtcgg gagatatcga cgaacatatc gctcaggtta tcaacgccga ggagaaatac 5040 gcagataatg acgataaagc gaacaggttt gctgtagaac aatttcatca ggagctatcc 5100 ttctggggtg aaatgacacc agcattacac catatcagat gccaattttt tttcggtaac 5160 gggcctattt tgacaagaaa aaagacacat cagggaggca atgacgagag tattttcgag 5220 gtgcctatgg cctgtcactt cctgaactca ggaaaagaac gatgctgtag aacacaatcg 5280 aaatatagaa aagtaacttt tccaccgacg atatgtccgg cggcaagtta ttcttatgca 5340 gggcacaaat cagtgaattg ggttccgcgc gggaaagtca aaaaaacttg catgtcgttc 5400 cggatgccag gcgacgtagc acatagattt gggcctgtgt aagcggggag ctgggacgtt 5460 ttgtgtctgc cataatgttc cttttataac gagggctgtc cggctgacag attagcggac 5520 agacctgaaa ataacgtgca tatccagcac ctggctgaat ccctgagcga ggcaaatgcc 5580 tttactcttc cccctccgac aacaacaaaa atgcgttgag cttcctcttc ggcctgttca 5640 tcagtcatgc ttttctcgcg gatgtgcgaa gtaaacaggc tccagtttgc agcgataaaa 5700 tcacgtactt gatgcatttc cgaattctca gcgtcaataa ccatttttag tgtcctgtgt 5760 cttaaataag gtccgccctg ttaatagatc agggacggac tgtttaagcg agatagccag 5820 cctgtgccgt ggttatccat tcaccagagt gatttttgtg ggggatactt tgatactaaa 5880 agcattaaat ttctttttaa gagcgagttc aaaccacgcc accgggatag agaccgaact 5940 atcatcgccg cccaatgcct cctctgcctc gtcataccat tcatcatcaa cagacggatt 6000 catcccacgg gcatagacaa ccgtatcacg ggaaacaggg gttccatcca gagatgcatt 6060 ggtaatcaga tagacgccat gatcttttac cagaaggatc tgtggagtca ggcgggccgg 6120 gtcaatgtgt ttggatgatg gccagaaaat tccccccgtc tggttcattt ccacttctgt 6180 tttgccctct tcgttgagag gagtaccgcc ggggtaattt gacggttcaa aaagctgttc 6240 aatggttgca ttgaaccgtt ccgccgagcg gagttcttcg aggagctttt ttaccccagc 6300 aatttcgaat gttaatgtgg tcataaactt attctccatc cgtagtcagc atcagatatc 6360 gggtggccag tagcaactct ttgacgtcag cagttgaaac ctcccctttg ccttctaccg 6420 cgtcctgcaa acgctgacgc gtcgcctgaa tcgtctctga cgacagtgac gccagtttgc 6480 tcaatacagc gttagctttt tccacagcgg gatacaggga ctctgaggtg gtattgtcta 6540 catcgttatc gaaaaacagg tcagactcca tattaatatt gtcttcgagc cagctggtaa 6600 gaatatcaag taaagacata actttattaa tctgcatttt tctcgccctc ggttgatgta 6660 attcaaatat aacaaactgt ctcgtctggc taataaccca gaatgaaaaa ataagcgatt 6720 tattagatag gactgaatta aatttaaatg gagtgcagcc ggactcagtt taaaaacact 6780 ccgcgctaaa ggcagaaaaa agccttccga aagggaaggc ttatgcacta catcaggaaa 6840 agaactatcg ctgcttctgg agcgcgatat acgctgcgaa aacagctacc aacaccgtca 6900 tgaagtaaac tagatatgaa ccagattgcc agacattaac gccaaaaaac gaaattaatt 6960 ttccgtccgg gataacagaa aaaatcaggt tccagaatcc aaccagaacg acctgagaga 7020 taatcatttt accaagcgat cccagttcat gagccgcata cattgcagcc atgacaaatg 7080 tcagagctac cacaagcagc gcagacaaag ccacaaccga aatgctcagg ccgacggatg 7140 taaacagaat ggcatcttta aaagtcagac ctgtaaaacc ccagatcaga atggctaaaa 7200 tgaaaaacat aaggataaat ttcactagaa ttgcgtccct ctttcggtgg cagagtgtcg 7260 gtcaggatgc ctgtggcgag gcaactacag acagaattta acacaaaaaa tttaattaca 7320 aatccgttca caggcctgtt tcaatgattc tttggtatgg ctatgtgcgg cctgatttaa 7380 caatgcccgg atgtgtagtt catcatgacc gtcagctaca aagagattga ttttactttc 7440 aaggcggctc atggcttcgt agagttttgc ctctttattg ttcttcataa agcgaagaat 7500 gtaatccgca ataatatgct ctggtggcgt tttaatttca cggcagcgat tgcttgtcat 7560 gagtttttcc tcaagtttgt ggcaaaatgg caccatctca tttaagccac ccttttccgg 7620 ttgtataatt aatttgacct gctttacaca gcgccagcaa acggcgatca agaatatgcg 7680 acggttgcgg attgctttcc ccggctgcaa tccggtgaca ctctgctttg atctctccgg 7740 caaataatgt cgagaacggc gtaggaactg gggtaagaat ttcgttgagt gccctgtcca 7800 gcgccagata cttatccata ttcatgtcct tgcaggtaat tgaatggatg gggtttaaat 7860 ttattatact gaatcgagtt actaaactaa tatccttcag gatgaagaaa ggaatcatcc 7920 accttcagta tgtattcgac atataggaca cgtctctaaa atttttcgcg ttttcgcgat 7980 ttacaccgac aggcctacca gtcaccacct tcgatatgaa gttgcgtcgc agaaacagcc 8040 accatttcct gcattggctg gtcatgcttg ttatgactac tcccaagcag taggctcacc 8100 ttgccgttag cggaataaaa catagcatca ggaaaatgct ctctgacttc ccccagcaat 8160 gtgtgcatcg actgagtcag tcggtagaat cgacgtgcgg cagtcggcat tgcatcatca 8220 aggagatctc cggcgtcgcc gtccccgctg tttatgaaac tcagtacctt atcttcgtcc 8280 attcgaacct ctttttcagt catgtcatat atatccattg agatatctgt cagcctgagc 8340 aacgacatca ggctgacctt cgctcacccg gtaataacga tggcctgttc caattgtggc 8400 tggcgatccc cccgcagcgc taccgactcc tggaggcgtg cggaaggcat cgtcattgcc 8460 ttaaacccct catcccgcga acgcaccagc atcccccacg aatgggtttc acagacatcg 8520 ttctcgaaat tgggttcggt cgacagcagt gattccatct tcggttcgat gtgtaccggc 8580 gcaatgtttt tataaacagg gtgaacacga cactgttcag acgcttgtgc tcggtagctc 8640 ccttgcgcca gcagcacgtc atgggaaacc aggtcataat ctgtatcttc gacaaaagtc 8700 ttcagggtgt gcgttatttt gccgaatcct tcgatattcc agacggacac catcgtaaac 8760 tcttcaaacg cacggggact tttgaccaaa aatccattca gcgccctacg ccccttcagc 8820 atccccacca ggtattgctt gttgggataa gggcgcatcg caacaaggtc attaccagtc 8880 aggcgtagcg acagttccgg gacgcttacg gaatccagcg tgcaaagatt tcccatcgga 8940 tgcaggattt ttggtacaag gtgcaaaaac atcggtattc tcctcgttta ttaagccttc 9000 aattattgtg ccgtcgcctg atgtatttcg aaccagaaga caaccggctt ttccgtgact 9060 tcaattaacc caaatcgctc tgcggttctg aagttgacgc tgtatgccct ggcgcgttct 9120 acctggcggc ttatttcttt cctcatgcct tcaacactta atgcaccttt aaagagattg 9180 cagggggcgc aagccggaaa aagattttcg attgcatgca gttcagggtg catgacctta 9240 ccggtacttc gagcccggtg tgtcactcga cttccagcgg gggctctgac catttcaaaa 9300 tcccgcctca ccggttcaac atgatcggca tgccagcctt tttccggcaa aggacagccg 9360 cagtaggcac accgaccgcc aaatttcaaa cgcagttcgg ctcgttgctc tttggatatt 9420 ttattttttg gttttgaaaa tcgcccatca tcagattcaa ccttcgggag gagttctgaa 9480 aaattgggta attcgattac tgcgcctttg ttatttagaa ctttcaccgg acctcccaac 9540 catattaaga cgatttttta tttattttcc tgaattagtt ttcgaatttt aatcaggtgt 9600 ggtcggctta atttgcatag ctgttcggtc gcggcatcca gagtgggaaa tacatgggcc 9660 tcattaatat ccagtgtcca gtatttcgct ttaccttctc ccagatcaga ttcaaagtaa 9720 ttccgcttta ccccaatctg ctttggtctt ccattaattc tgacgatttc atgccgctcg 9780 tcgaagataa aaccctctcc gaccaacgtc aggaggacaa aagggccctc ggccttttgc 9840 gtacccagcg aactcatctc attattcata cgacctcccc ggtaatacgc ttaaagttga 9900 cgacccagac ccacgggttg gcctgccaac tgtcctcgcc gtacgtgttt ttccagaggc 9960 tgcggaagcc aagaaagtgc ttatcgccaa gaacacaaca ttctgttggt gcgccttcag 10020 ctttggcatc ttcctcgctg atggtattta accgctctac ccgcaaatcg gtaatttcca 10080 gtgcaatacg gctggcccag cgaggcatat ggattgaagg tgtccacgca ccttcgaact 10140 tcatattttc ggtacgaggc ttccagtcgg cctcatcagg gatcgaccac agcccataat 10200 cccccgaccg ctgttcgcag ctcgcccggt aaatgcgggc tgcttcagtc ctgtccatca 10260 cgatgttgtc attccagtcc accgcgcacg catcttcatt cccgagcaat gaaaacgcct 10320 cacggaccgt aatgcggtcg ccaactacgc cgtacggaca aggccgaagc gccgagtatg 10380 gctgggtccc tgttggaagc caccagtcat gcgtgtgccc gcgatgtcgc ggtgtttgcg 10440 caggccttat agaccattca tccgaactat attgaggctt tataatccgc cgcgtctgtg 10500 ttttctgatc tgccagaatt gcccggacca tttcatcatt aaaaagcatt ccacgtgtct 10560 tcactgtgct gactcctttc acacatggtt cacacattga gaggcctatc cctctttatc 10620 agccaggcat accgaaactg tcggtagttt tacgggaacg ggcaactgcc cccctacctg 10680 ataaagtggt gttctccccc aaaattaatc gtattcccca tccactaccg gctcagtcgt 10740 aatttcatat ttcactccgc cgggtacatc caacgcttta gcgacggact cacacagcaa 10800 tgacaaatca ttcagggtca ttgggtattc aacttccagg ctgtgcagtg cattggcgct 10860 ggcagcagca gccttgtcag catgacaggc attaaaaacg aaaacggtgg ttttttcttg 10920 aataggcata gtgcaatcct ctgaataatt agccctgtga tcagggcggt ttttgattaa 10980 atttaaatgt tcgttttcaa taattagtga atctgttaat cgggttgtga cttatcattt 11040 tctccaaccg aagtgctgtc gagaaatgac cattcttgtt tggggctttt atataatgca 11100 ctagcctcag tactcatcca tgactcacag gctttataag tcatgccttc ctctctaacg 11160 cggtccttaa aatacgccca ggcttgcaga tcaagcggct gatactcttt cagcgactgg 11220 tcaagccttt ccttccagat tttcttccga tgagtaaaat gaggaaaagc caggaatgca 11280 taactacctg caacaaaaaa aaagaacagg agtccgcccc atagagaatg tttgaaaaac 11340 accagtcctg ggaaaatcca tgccacaatg gcaacaaata aaagaaggtg ctccttccca 11400 gtaggtttat taaaatgcca ggaaattgca atacacttta atttactaaa gtgattttgt 11460 ttctccttaa tatcggtcat atatcagtcc ttacttataa aaaaatggtt attattagtc 11520 tgatgtaaaa gttacttttc aaaacagtcc ctttaacgaa ttccgcacct gcgctcatta 11580 caacacacac cattcggcgc tttttccgtt aacggggcta ttttcacgtt ttttgcacgt 11640 atgtctgatt ttgctggtgg gctcacgcca gcaggcggac catacgtttc aacagaggcc 11700 ttaacaacgc cgccgtcctc tcccggcatt catccacatg ccggaacccc gtctttttcg 11760 aagactgggg gccggataac atccgcagct cccagatgac ttcccgtaag gttccttcgc 11820 gctccggcga aatacacccg gctaatgtct ccagaaagcg ttttcttacg gcccggtaat 11880 acagacgttc ttccggttgc tgtgacgaaa tccgcaggtt acagagggtc aggacagcgt 11940 caagagtcct tgccttcagt tcgtctcccg tccgggccag atgtagctgt tgttctgtct 12000 ccagttgcgt cgttatccac ccccccagag gggttttgtt gtaggtgtgc agtgccacac 12060 aggccgcaac acagcaccag aagcgcagtt tctgccgctg cccccgcagt ttgcgggcta 12120 cgagcaagcg ataatcgctg tcggtcagga tcttgaaacg gcggctggcg agcagagacg 12180 gcagcggcgt ctggtcgtta atgccaagac gtgaataggc ctgcccgcgt tgagcgagtc 12240 gatggtacac cgcacctttc ccccgcgaaa ttcggacggc gccgtatcta agcaggtact 12300 gtgccgccgc cacaggggta aactcaccgt cagacacacg ctggcgtaat ccgtcatatt 12360 catgccagat aatccaggat gccgtgtctt catcgaccgt cagctcatcc tcttcttcga 12420 atgcaacgat gttcaggcct tccccgctac tcatcagact gcgggaagct cgctcatcct 12480 cccgaccgtc aaaataggct atttcggatg acggatcgga cagcccgtca aatgacgtcc 12540 cgatacggcc ttccggcaac ttcatccagc gtggtgctgg catcggcgtg cggggtactg 12600 gttgcatagc tggctcatcg tcgagaagat ccagtgcccc cccttcccac acctggcggt 12660 aaagttcaat ggcacgaaat gggcgcgggt taaagcaatg cagtgaccag agaaagtcga 12720 tatgcagcac gttagcctcc tgcaccagtc gaaactgcgg ctccgacatg cggcggttat 12780 gcgcggtatc ttcgatctcg cctgaaagta acttttcatg caccgctgcg gcccgctgag 12840 cctccacgta atcgaggctg caacagatat ggaacagtct ttcggtcagg gacgacgaga 12900 acacattggg ctgaagacgc acatacccgc cctcaaacac tttgcgtccg atataatccc 12960 gaaggctcca gtcgtactga attttggtca ggaaacgctg aaggcggttg agaccagcct 13020 ggtagccgta cttctcaggg tcagtgcgga gtaaggtttc catcgagtga tcaatgccga 13080 cggcgcagca tagcgagcat ccatagcgag cgccgcaggc agaagaccgg acagtggatt 13140 tctccggcgt ccagatacat tccccggtcg cgtctttgta aagcgtggcg aggctgaagt 13200 tgtccggcaa aaagcttggc agcggaaatc gcgccagaga accacaggcc atcagaaatg 13260 accagatatc ctgtgcccgc cactctttca ccgggtacag ttcgccgccg tgctccgtga 13320 gcgagacgct gtccgcctgc ccgcccattc ttaggatgtt gtctgcccga cgggcgctct 13380 catcatcgcg ggaacccagc atcaggcaca ctttgttgcg gacagaagca ggtgcatttt 13440 tcagataacg ggctttggcc tggcgcagtg gagaacgctt tagatctgta gcgcattgac 13500 gcgtagaaga atttgtccag gttggaagtc cacgcccggt cagaatgcgt ccgacccagc 13560 tctgggtcat ggacgggcgg gccacaagga cggtcaaagg cagttcttgt tcggcaataa 13620 aggctctgag ctggctgaga acctgcgtgg cctgatgatg catctcaggg ttttcaatca 13680 gggtgtcaga catctgaatg aagtggtgct ggctgacgtt cgacccgttt cgtactgcac 13740 ggatcaaggc cataaggaac aagtgcagta gcgagtgaga gtctttcccg ccgctgtagc 13800 cgacgcacat ggtccagcct tcggtaatcg catgataaat ggcactggtt gccgtcgtca 13860 cgcgcgaagc gagactgacc ggctcaccgg catcagtata attcagatcc gcatcggtct 13920 tcagtgtctg ccagacatcg ccccatttat cctgcgtcag aatggcagcg ttagccgcct 13980 cagaaaattg aatttctgag ggtaattcaa ggaatgtttc tttcatttcg atatacatat 14040 tatttcctga atttggcttt cgctgtattg tcgcgatatt tattaaatcc atttaatatc 14100 ttcagcgcaa tatgtgaagc taaaaatagt taaattgaaa tcatgccaat ttaattaaat 14160 aacactgaac aaataaaatt acgcggcaat aaatatatta tattctccac gctctcacga 14220 atactgctgg gtaattaaaa ccgtcgcatt tgattccagc tctgccaacg gaattagggg 14280 cgtattgagc atcatgtcat cgccgcaatg acggggtaca gccgtcagat gaaatgattc 14340 tttcatgacc cggatggaag ttgtttccgt gcggcaggag ggcattacgt cccggagcat 14400 cgtttcctgt ccgctgctgt cactttcaat aaacgcagcc tgcgacatga gaacctcaat 14460 gtcctcttcc aatgtttcgg accagtggca gtcatagaag aaaaactcgg cggcgtacaa 14520 atcattttct ttcacgtatg ccgccagttc acggatacgc ttagccagcg acgtatcaat 14580 ggaaaagaag acgctttgcg ggacatcact cgcaaattca ttgatgcagc tagcggacaa 14640 aatcaggatt ttattggtca ttttcagctc tccatgccac cggctgttcc ggtggcaatc 14700 agggattatc aggcagtcac ggggcacaat tcgtcaagtg aaggcagtaa tttgctcagg 14760 ctttcgtaca cgacgggcat caattcagtg acgctgtgaa gcgccatgct ggtattgtct 14820 tcttcgctga gaatgataac tccatcctca ccaggattgt cgggcgtgct ctcgtcagag 14880 gccaggcggt ggcgtgcaac gtcataagcc gattctgatt ttttgcagct catcagatag 14940 cattgagtgt atgtgtattc gtggttgtac tggttcactt tcaccaacgc atactgaaca 15000 ccggcatcat gagcttcgtt catcaggcga gaaaaattaa agccttcttc gtagtggtgt 15060 gtatctttag tcaccacaat agtcgcaccg ccgaactcgt tttcgcgtgg tcggtcgcag 15120 acgaaagcgg cattgattgt gaccatctca ggcaggttaa acaccgacaa cacggcagtt 15180 gttaccgcga tagcgtggtc gaggttaatg ctttcatcat ggcagattgc caggccttta 15240 ccggtgattt ccgctttgag ttccagctcg taattgtttt ctggtgactc cgactgacca 15300 aaagtcggct caaacggatc gcactccggg tggttctgaa taatacccag gacaagcaat 15360 tcagtgaggg aacactctga aaccggttta gacagcaagt gttcaccttc cgccacatcc 15420 gtgtctgtaa catacgcaat cgcgtccagt gccatctgtg cctgttcctg tgaacagaga 15480 attgtgaagg atgcctgagt gtaattgttc gccattgcat aactccttat ttaattaaat 15540 gtgattgctg tctgtgaata gataatatca aaacagatac ctgcacctaa taaccaataa 15600 tgaaatatgt tcgaaatttt tatagagcag acagcgccat atttaataat ccaactttta 15660 ttctggatac ggtgtaaaat aaatatacgg gaaaacaaaa aaccgccaca agggcggaat 15720 ttattagacg ggaaagattt ggttatacgg tatgtgtcag ggaggaagca atgagcctgt 15780 ctggtaacag tgattgtagg gacgcagacg aaataacaag cacctgatcc aagtgcgcta 15840 caccttcgtc gatatgttgc tggaatgccg cttcagcttc accgcaggag tccgcttcga 15900 ccagcatcac ctcttcctca tcatcaaaca tcatgcggcc tgagataata tacagtcggc 15960 ttaagtctgg ggtatttaca gcgatgccct gttagttaat catcattttt ctccgccttc 16020 aatttttaaa tttgtcagtt ctgctacgtg taaaaaacag catcagccct gtaaacccgg 16080 acaggtatca acgtagctca ttggtttgcc gatcgcggcg ctcaggcgaa ggatttcgcc 16140 gatggagacg taccgaagca tttccgaacg cccgtgtttc tggtattcat ccaccgacat 16200 agtgcgccag tccttgtgcg gtgcggtttt gcacaactgc cagttgttgg cagtggtcgg 16260 gcgacgcagg acatatacac ccagcgaagg cgtgaggcca ctgccgaatg cctgctccac 16320 cacaatacgt acttcagagc cgtcggggcg tttcagtgtc tgagtaattt tagtaatgag 16380 ctgttcggat tccatactat taacctcgac cgtcagttgg gttgctgtag ggatatttta 16440 ccaaagtcgg ctctctggct aataagtaag aagtgatttt ttttcattca ttgaagtttc 16500 tttcatatgg aatgaatatt aattatttaa actgactcgg cctattttaa ttattattaa 16560 tcagggtatt taatgtgcaa attggcaggg cgctgaatta ccgggcatcc attgcccgga 16620 cagtttatta aaaaaactga taatgccccg ccggagaatt acgccaattc ctgtgaaggc 16680 atggtctggc tgaaaagtta cttttcccgg ttgccctgcc ttgatcccgt atcgtttata 16740 ccggtctgct cttacatcct acctgggcag cagctggcta cggtgatcgg gtattaaaat 16800 agaaccggtc tgttttaccg cagattcaac gccccgcacc tagcgtaaaa tcgcctttcc 16860 cggatgccct ccttagtcgt ccggcacgat ggcgctactc ccagcgataa ggggtaaaat 16920 agtcctcgtt aacagcaaga aattcggtca gggaatgcat cgccttcgtg tcatatgccg 16980 tcacaataaa acggtatccg tccaccgttt cgatgtagct gatcccccgt ggcgtgcaac 17040 tggatttcac aacttccgcc gtcatcataa actgcccttg cggaaattcc ggtgacaggt 17100 agataaagcc agtggtggct gatgacgggt tggcattcat cagcacgccg ttaaattgct 17160 ttccgtgccg cgccggaatc aacgcgctcc ccgctgtcgc ctgagtcatc aactggcgga 17220 tcagggtttc ctctttatct gagctgtagg cgcgaacatc attttcagcc ccggagcgtg 17280 agtagacgcc gacatgagca agacgtcggt actcgttacg catataggca tgacaggatg 17340 caccggctcg cccctgaaga gtgacgccaa agtcttcaca taacatcagt acctggcgca 17400 ggtttttgtc atagaccgtg gcagagagcg ccaggttata gctgatgaat gtcagctcaa 17460 aaacccgggt atgtgcgtca ctaaggtgtg cctccatgcg gatcactggt ttctccgtca 17520 ttggaaacgg cgtaccggcc aagcagtacg aggtaacatc gctaaaacac tcgtcgatca 17580 cactggcaat gaccgtatcg gcgtcaatga cagccggagc tggaacataa atctgaaact 17640 gtccttcagt gcccggttgg atcaggacgg ggtatagacg cggggaattg agttgttcgc 17700 agtcggcatt gatcagttct gtccaaccgg gttttccggt gggagcatca aggcgaagac 17760 ccaggttatc gcagaagtcg acgatctggc gggagtgctc caccatcact gccccggaga 17820 gtgtcagacc gtgcgtaacc atctgcatct cactcgtccg ggtctgggag ttctgggacc 17880 agggctgtaa tgaaagcgtc gtccgactta aggagggaat gatggtttca ttcagaggtt 17940 caataagctg gcaatgcgca tacagccggg tggcgaggaa gtcaaatatg aagcttgcct 18000 gttgttttgt gctggcctga atataaaaca tcgcatccat gcctgaatcc cgggatgaaa 18060 taccgaaaag tttcattttt taccttaatg gatgagcgat ttataatcat gcgccgacag 18120 gtggacgtta tgtacgccat cgttccactc aaagaatagc cgatattttg aattaactcg 18180 aatggaagaa taccggtttg cggtcattct taagcgttcg taccgcaaac taccagataa 18240 caattcgcgt tcgtttttaa cattatttaa cgtttccagt ctgcatgaaa tcgcattaat 18300 cagttcagca ggaatgcctg ccgtggattt tccattacgg aaaaactttt ccaatcgcct 18360 gtctttaaat gaatggatca tattttcctc cgtaacgaaa tgagtttaaa taaataagaa 18420 ttaaaaaagc ctgaatctaa tttattacat cccgaggatt ctggctgcga ccgtcagttg 18480 tttatcactt aatggaaatt tgcgtgataa cgtcgacttc aggctgttca aaaaactgtt 18540 ctcgccgtct tgctgcgtga tggcgtccac cagttcttgg tggttctgac accagaggtt 18600 gaacgcggaa gtctttgatt gaacagcacg ttgacgctct gctgcctgag cggctgagat 18660 cttgcgagca gcttctgggt atatgcgata cagtgcagtc agggtgtaac aggtacgggt 18720 agtgaccagg ctatagccag tggcattaca ggcaatacag cggctcttat aaaagtgatt 18780 gcgttcgcca cgtccattgc atttattgca agtaacacgg taaatatatt ccccggtgcc 18840 ttttactgaa tcaatacact taatcttagc gttatcgatt gccattccgc tacggtcaaa 18900 gtatttatcc atttttgatt cctcaggttt ggtctgaagt aataatgaca gattggcctc 18960 gctggctaat aacctgaacg aacgtttttt gaaaataaat caggaaggat gattgagatg 19020 atttatatat gcaggattca attttaatgg agggtatttt cagaattatc tgtttacaaa 19080 aaacgaaaca aatcctaatg aggcatttat tgcatcacaa taaaagtgat tgcttttcac 19140 tcatttgagt agcgatgctt aagtatttat ccgttttaag gtataacagc agcgtgatac 19200 ggctcaggga atgcctgtcc gtcaccttaa tgatgcttta cttccggttg ccgaaacagt 19260 ccatatggct gacatgtata acacgcacgg tctaacgcag ttccgggggg tggcacagcg 19320 gcgtgatgcc gctttaatct ggaaaacgca ggcatctact ggtgcctcag gatcgcggca 19380 ctcgcaagct gaaacaccag agcctgttcg tcttccggct gtatcgctcg tccccgtcta 19440 caaaacccgt ctcatccgca ggtatcgctg gcgcactccc agacggttag aggctttcgg 19500 gaactgcctg ggtcaaagaa caccggcgtt caggtagctg ttgaaatgga catctacacg 19560 tttttgttca agtgattcag ttgtggtgag ggcataacgg gtaatgccct cccgtgaagc 19620 cctgagaaaa gttacttttc caggattaat gcagtcttgc ttttaatata aattcagggg 19680 atattttttt aaaaaaatac ctgtcgtcaa cttattagaa aagtaagtca aaatgctaga 19740 gtgttctcat tcaaaaagag gagaactaac catgccaaaa tatttgttac ctgccgagct 19800 tgcggaaatt gtttgtggat tactggtgca accagcatta ttgaatgaat taaaaacacc 19860 agccacgcat aaagcattta tgcaggacat cggcgagctg gtggcgaaac attgcggcgg 19920 tcaaattgac ggcgtgatca tgcctgaggt acgcgatgaa gacagccagg ccgattacct 19980 gacatctcca gatgaaaccc cttatattgt tgtctctcct ggccaggaca tgcactccct 20040 cacagataac gtctggcgtc atcatgcccg ggatggctgg cttgaccata tcaaaggcag 20100 tgtcgaagaa agccctgatg aactgccgac ccacaaagag tgcgctgtac gccgctacac 20160 cctccagcgt ctgctccttc aggaagaaac cagccatgct aatctgccag tacaggtggt 20220 acggatgtgt gagtacagca ccgacgatgt tgagcagacc gattcttcag cagagtttaa 20280 cgtcacaatg gcgctcggtg gtcatgccat gctggcagta aaagatacag attcccgtct 20340 ggtgatggcc ctgacactct tgattgaaaa tggagttccc tctgtccacg ttaatgcggg 20400 tgacactgat ccttcagttc tgcacatccg ggcagctcac ggtggtctgg ttctttcaac 20460 cgactccctt aatcatgatt tcagtatttc gccctctgac cagtatacct acggacgccc 20520 tggattatta ttgaaagccg cctactgatt tattaattca aaatccgtca ttattattta 20580 cccccatttt tcgcccctaa cttatggggc gagtatattt taaaaaactt tctttcaggt 20640 tattagccag caaactagaa ctggtagaat taattcatca gagaaaaggg gactatcatg 20700 gctaaattaa tttcgacgcg tgaactggca acaattatta ctgcattact ggtaaaacca 20760 gaattactgg gcgagctgga ttccccagaa aaacatcgcg ccctgatgga agatctgggg 20820 cgtgttgtgg cagagcattg tggcggtaat gtcactgaaa tcgcactacc ggagaccgat 20880 ggtacggctg ctgaaggcgc gttgcagaat ggccagcccg tccgctatct ggaaaccaaa 20940 gaaagctctc cgtatctcat cgtacaccct gacgcctcac tgccgtcggt gacgcaaaac 21000 gtctggatgc acgctgatca tgatggctgg gaagagcatt tcaacggaga gaccgatgcc 21060 ctgactccag agatgagcga gcagttccgc cagcaggttt atgcactgct gacgccggaa 21120 tcccatacca cctcttcaga aatgagactg actttgcagg actggcaact gggtgaagcc 21180 gagatcccag aagaagactg tcagccctac caggtgaagg tgttagcaga aaataaaaac 21240 gttcagtgcg aagtgacgaa tgaaaccggc accacgtgtt tcggcctcat tttggagatc 21300 gaccgtggtg taccgacgct gcacattgat acgggcagtg attcactgct gcacattcac 21360 gcggcacatg acggcctggt tctgacaccg gatgcaccga gccacagatt tgaagatgct 21420 cctgtagatc gcttttctta taacagcccg tccctgttgg tgcctggggt gtaaccaggc 21480 aaactgccca gcggtatttt ggccccgggt aaaattattc agaacaggag tcaggcagat 21540 gggcgatgtt gccacactac caccgaaaat taacgatggc gtacttcgac gctggaatgc 21600 tcgcggtaaa gcggataaag aggcgctggc cgactatggc gttagcgtga aggaggagtg 21660 aattgcgcga attacttgga atggcaggtg cagaacatca agcctccgta atgtatcaaa 21720 cgttcggaca cctcgacgcg aagctaggcg aaaagcataa aggtcacttc gtttttatca 21780 acggccagca cggcgatctg tgcgttgtgc atagtgaatt ttcatccttt gacgaaggtc 21840 caggctattt cagtgaccgt gccgacttca tctgggaatt agttaaaaac gacggcccat 21900 gctctaaggt cgggatttac cgatttgacg gcgaatacgc gcttcctaag cgccggaatg 21960 ggagaagatt ttcaggaagc gtaacgtgcc tgcaagcatt ctaattccgt gctgcatgag 22020 cgccgacagg tcttccgtac aacgggaggc ggcacagttc gcgtgcaacc atccccacac 22080 aataactcga ctgagtacat aataatgacg aacgctaacg caaatgacgg gaagaccagc 22140 ccggtattac ccactctcga acaggtctat gctctgctca aggccaacta taaacccgca 22200 cgatttgctg atcgggatgg ggaaatctgg gggcatgagt attcatggaa cttggcaaga 22260 tccagtttgc aagacctgga gaaatacggg aaatcatatg tatccaagca ttccgaccgg 22320 atgggcgatg gattcagttt tggtcctgac ctggtcatta ttcgctgaca tacgcacgga 22380 agtgagtaag atggctggct gcgccggaga actagagtaa tgaagggtaa aaatatcgtg 22440 gctcgtgtcg tgcgggaagc ggcctataag tgggaaactc gccaccaatt gcagcaggcg 22500 tacaattcag cgagtgacgt gggaaaagtt cccagacatt ccggttccgc atctgattta 22560 cgccagacgc tgtcattttt aattctttgt agggcatgac gatgaaaaac acagtaatac 22620 cgacggtgac tgaaaacgag atgggagagg tgatcacccg ccactcggct tacggactgg 22680 tatcagtaag ccgcacgtcc acgacgggac agcgccttta tgcctccgac ctcagtcata 22740 aagaggtagt cacgatgacc ttcagtgaat cagagcagat tgaacgcgac ggtgtgatcc 22800 gtcatcgact ggcggaaggc cgacgccgct caccgctcct gcaagtcagt ctgtctccgg 22860 cgcagtgggc cacgatgatc acatcgttcg gaatgagtga cggcgtgccg tgtaccatta 22920 acagcctgat tcgcggcgat tatgagcggc agccggagat tggctatatt gagtcgacac 22980 gcgaacgata cgaacggcag atccgggaag ccgctgagcg tgaaatggcg aaattgcatg 23040 aaaagctgga agtgctgcgt ttgctggcgg taaaaggcaa ggctggaaag cgtgagcttg 23100 acgaagccta tcagtcgctg ttaagcgtaa tcaataactt gccggtcaat ctggccttca 23160 ccaaccaact cattcaggaa tccatggtga atatcgtctc acacggcaag gccgaactcg 23220 aagccaccgc catgggcgta gccgctcgtc tgggtatgaa agaaatgagc agccttgcct 23280 cgctggaaga gaagaagtaa ccggtgcgcc cgcccgtaaa tcatgaaatg cactaacgtc 23340 catacctgct gcacacatac gcggcacaca gatcaacggc cagcgcatac cgcgttgaca 23400 taaaccgtaa acactgaagt gcgtcgtcct gtcggggaca ttctacgtgg ttttctacgc 23460 cccccccttc tctcttctgc ggctcacaga acttcaggaa ttgctggtgg gcagtctcca 23520 ggacgttttc cagtaaccgg ctgtggtcag cgtcatatcc cttcagcagg cgttccagtt 23580 ctgccatagc gagtgcaggt ggtaaccaga tgacgccaag cagcaaaaac tggctctgca 23640 ttcgaatttc atggcgatct ggcttcagac cctctgcccg ggaagcgcaa taataaatcc 23700 tctccagggg agctacacgc gtgataagag gtttctcagc aagttctgac atgcgactaa 23760 atcagcctgt ttcgtttctt tctgattacg ttaagacact atgaaaaagc cccgtaatac 23820 ggggccggtt cggaggcagt tactggattt gcggcagctc gatcatgaag cttgattcac 23880 cgacattgcc gctggtggcc gggaagatgg ggatcaggac gccatcaccc tgcccgaaat 23940 ctatcgtgat gtctttcgaa tccccgggta cgacggccac cccattcata ctaaccgcaa 24000 aggccgcatc tttgcggacc gtcagcgtgc cggtttgtgc tccagtgatc agcgaaccat 24060 cttttttccg gatgctattg gtacgcagat acgccagcgg ctggttatct gatgtcttca 24120 gccccatacc cacggccagc gttttgagag tgttaaattc aatcaggttg ttcggtacat 24180 aacggaaccg gctgaccttt gtcgtggtat taccggcttc atctaccgca accgcagtaa 24240 gctggtagga atccgcatca tctgtcgcgg ggaagatacg cgggtagttc agcccgtatt 24300 tatcagttcc ctggctgtac cagcccacac tgactttgtc agaagtgggt ccgccgctca 24360 gcgtgatgct tttcagggaa gcttttgtca tatcgtcggc cagtgtgatc accagatttt 24420 ccagcccttt gaccagtgct ccgtcagcct gctttccctc aaaactgata tcgacaacag 24480 gcggcgtgac gtcatgcagg atggtattcg atagcgtcag ttctgccgtg ttgttgtagg 24540 tgtccgtcgc ggcacccgtt gcagtgtatt tcccggaggg taacgcgctg taatcaaacg 24600 tcacttgttt cagctggtag ttcaggaccg taacgttttt cggcgacaag gtagagactt 24660 tattactggt gtccttcagt gtgaggttaa agatattggt ggcccacata taattggtcc 24720 agtcgttagt tacgtcactg tccgtcacca gcattaccac cgttttatcc agtgggctgg 24780 agacgatact gttgataacc ggggcgttca tatcccagta ggtgtagaaa tgcgactgta 24840 gtccgccgag atttgcgtat gaaccggtcc ctctgatatg aatttggtac ggaacatagc 24900 ctttcccgct cgtcttacag taattcatgc tgacctggca actgctctca cccactgaaa 24960 cattgcaact gccaatgccg acgatagtag cagtttgcac ataagagcgc ggttcaacgt 25020 ttacacgacc caaatctacg caatccggcc cggtaaacct gacgatgtca ctcgaagtcc 25080 atgtattagc atctctgaaa tggtactgcc ctgacaaata gcggggggct tcagccacgc 25140 cgttacccgg agtaaatttc agcgttttgt actggaggtt gacgttaagg cccgctttag 25200 tatgaagctc gtagtacata taggtttccg ggtagctcac cgtggcttca gtataaaaat 25260 aggtattgtc ggagttggta atctgatcga cccagccgaa gtctgtcccg ttaaaattgg 25320 ttgagtccga tttaaggcgt ttgtacctga atttgactgg gttctcgaaa atagtcatgc 25380 caggaacata atcttcccag acgcctgttt tcgcattccg cacctgatgt tgaatgtagc 25440 tgggtattgt acgatcaata ccagagcgat gtgatgtttc tgtccagttc ccggctttgt 25500 cataaacccg aaaacctacg gtgtaatatg ccggactgac gggcgcaacc gtgcttcctg 25560 ccgccaccgc cgccagtgcc tggaccaccc ccgtgagtgc attcagctga gcatttacag 25620 tccggcggac accgctgctg tcaatagcaa accactccgc tttatccagt cctgacctcg 25680 catcagagac gttcgataac gaaatggcct gggttgcggt cctgtcgccg aaaatatcca 25740 gacttccgta ctgaaaacca gccctgatcc actgcatcgg atctggtaga acgggaggag 25800 tgatatcgat gctgaaagag tagctggttg tcgccacgac attcgactta ttgtcgagtg 25860 tttcggattt aagagaaaaa gtaccctcgc ccagtaccgg cagtgtcatg gacttgccgt 25920 agtactcact accatcagcg gcagtgatcc tgtcggccac tgtcaccagg ccggtgacac 25980 tctggaacat ctgcacatta tcggatgaac gtgtcacggt aacgcgctcg tagcggtcga 26040 gaccagatat cagattcagc gtaattgcgc tgcccgggtt gagatactct ctggtgggtt 26100 cagcattcac tttcgtgccg cgtgtgtcgg tatacgaata gttgtaaagc tgagcctggc 26160 tgtaaagcgg gaacagcagt gccgtataga cggcgacaat caacggacgt cggcaaaatt 26220 tcatttcggt tctcctggtt ggccagaaaa ttttacctga atcgttttct tcgcccgggc 26280 gctaagaggg gtaattgttc agtaaaacat cgtccgtttg tgtgcttttt gccagattta 26340 atcggcaggc ctgcgggaaa taccccatcc caatgtccgt tttaggctga ttaattcccc 26400 agaaatcccc cccttaacgg aaaaatccgc agggcagacg tttaaaatag caacaactaa 26460 aaggggaata ctgaatgaaa aatcaggcta tagctttggc tatggctatg ctcggagtct 26520 cagttccggc atctgctcaa atttatgaat ccatcttcac agataccaat ggtattgaag 26580 ttcacgcccc ctcaacccgg ctgttgctga atccggcctc accggtaacc ctgacgctca 26640 ttgccggtct tgaccgttat gtgaatgtca aaatcaccag cgccaccggc acgcaactgc 26700 tgaacaccac tactacgcgc accagcgtat ccgaccgtct gaaggccgga gatggcagcg 26760 aattttacgg aaaaaaagta actttaccgg tgcttggcga aggcaggtcg gttgtgcagg 26820 tcagtattct ggatctgaat cagtccgttg tagccaccta cagctacaac tggctggtag 26880 acaccacacc gctgtctggt aatgccctca caggcaacgc cgcctatgga tcaactgcgg 26940 gtagcgtctg gaaaatgggg ctggaggcca cggggcagtt tgattttacc tcaaccaatg 27000 tcacggacgt aaatggcatc gagaaaggta tgttttatgt ctatcacagt aacggcagtc 27060 tgttcagtac gacgtgactg gtcagaagat gtatcacact tactcaaaaa actcggtcaa 27120 aggcgcgggt attcccgaca gcaatctgga tgaagatttc acggccaagg tagtcattta 27180 tgacaacgca ggaaacaccc gaacccttcc gttgcagctc tttcgatatg ataactatct 27240 gggcggtccg agatccgcaa agctccgcca gcgtggtgcc aggggtttcc ggatatccgg 27300 cctattcagc tgggatgacc gttaatgaga atccgattca tcttgtatat cgcgtgccaa 27360 agtccaacta ccggtcatat gccgagggcg gcctgctatt ctataacctg tattcttccc 27420 cgaccgagat tgcgacggac agcacctata cctacgttga aatgatcctg ccctagtacg 27480 gtggtatacg ggctggagaa tatccgtata gctctggcgg ataacctgac aacaccccgg 27540 atcacccgtc ttcagataac cggagggcca acggcagata acgttgagct cacgtggtca 27600 cctgctggca cgaacgttta tgcgccagaa tatccaaggc tgttcccctc attcgagcct 27660 tccgaaaact atgcgcttag cgtgacggtc tccgacagtc agtcgaacag caaaacttat 27720 acccagaaat tcagctacct cccgaataac ctagtgcagt tgcataacct gcgaacctta 27780 tccgtcagtt cagcactcaa aacgtcgtta aatgagcctc ttgcttatct gtcaaccaac 27840 gtgttgcgta agtccaacgg tgagattgca aaaacgtcca gagtgcgacg ctaacggtac 27900 gtaaagacgc tgccttcggt attaagttca acggcgtgca ggccgcgctt ggtgaatctg 27960 tagaggtgaa aattgatatg gggctcggtg ataacctttt agtacctata taccctgctg 28020 aaaacggcaa agtgggtaca tccgagttca tgatccagat cgatgagctg aagtaatgag 28080 aatgggccgt cggtagtact ggcggcttaa cgaaagtaac tttttctgta agggttgaag 28140 tgtgcttctg atgtttttag aacggatcgg aatttactca cattttgatc gtgatgattc 28200 aatacgtgac agagcatagt tatcaacagg atagaataat aataaagatc aatagaggat 28260 caatagcaga tcaaaaagga ataacgatcc tcgcagccca gtgatatcgg gcctctcagc 28320 ggatcagcat ccactgtaca gggggagaaa tacactatgt cgggtaatcc atccactgta 28380 ccgggcgcat aatccactat accgggtaga ttcgatacac tatagcgggt aggatgtaga 28440 tcttatgcac aaaacggatc tcccaatatg tcaagtaata acaacaagtt atctctcgtc 28500 attgaagagt ccctaaaaga ttcaggggaa gttatacaac tctttcccac attaaaacag 28560 accattcaac cgaaagtttt actccgccta ggtgtgtttg tgccgacttt gaaatctacg 28620 gacaaggggg ggaggaagag ccatcatatc gatgccactg agccgctatc aaggttatct 28680 attgtagagg gtgaaggtta cagccagatc caaatctacg ggccgcgtct cgatatggat 28740 accgatttca aatcatggtg tgggatcgtt tatgcgttgt ctaaccggcc gcttgattca 28800 gaaggtcagc tggagctgaa ttttccggag tttgcaaaat tttgtgggtt tgataccaag 28860 cgcattgata aacaactgaa agagcgcttt gatgcttcgc tgacgcgtat agcccggacc 28920 aacatttcat ttattaagaa aatacccggt acagatgatc agataacgat aaacatgcac 28980 ctggtggaat cgacgtatta cgacagttcc acgggaaaaa tcatcatcaa gccaaattcg 29040 aagctcaata cgctgtatcg cgtcgacggt aaaacccgac tctacctgaa gacattgcaa 29100 aaactggccc gtaaggagtc cgcacaggcc ctgtacctgt atctggctga gctgccgagc 29160 accttttacc gcatcggatt cgatcggctt cgtggacgac tccaactgtc atcacacctc 29220 ggtaaccaga atgccacggt taaaaaggcg ctgggccagc ttaaagagat cggttttctg 29280 gaatactcca tagacaaaga aaacggcgat tacgtactga atattctaaa gagaaacatg 29340 aagccatgac cgatgccgga taatgcacct gcctgccgcg tgggtggctg cgttacccgg 29400 tatagtggac attcttctcc tttccactct gctttacccg gtacaatgga tctccactac 29460 accgggtagt gtcaggccta aaattacgat gcagcccctc ctcttcagcc ttacactgaa 29520 tatttagtgt gttttttcac caaaaatgtg atctataccc ggtacagtgg agtcacagaa 29580 atgtgatccg tacccggtat agtggatgag aactactgct aatcggttac cgggaatgtg 29640 gtggtactgg gtggaaaggt ttacccggta tagtggatcg tggcagtgtc atctttccgg 29700 atagcatgac gtcacggtta ggaaaccgta cccggtatag tggatagcga atggtgtaca 29760 accctgttaa cgtgatgatg ctgaagtgaa agtttaaccc ggtttagtgg agcgacttaa 29820 agcgcgtacc agtagctgat gggggagcag cacccggtac agtggagggg cggatatcgt 29880 cgtaaaggtc ttaactaaaa gatgaccatt cagtcgcagc attaaagaaa tatatcatcg 29940 agtctcaggg gttttaagcc ggtagacacc cttccaccag gagtcgaaag acaagctatc 30000 atcgcagcgc ataaatatgc cgttatgctt ggtgacaacg ctaagatagc ctttattttt 30060 cccgcagatc ttctcaaaag actctgttgc tttaataaaa ttttcaccat ccgtgatggc 30120 cggagaatcc agttccttcg ccagccatgc cggatagctg tccgcattaa cccatacaag 30180 gcgttcaaca actgaaaaga agacgccgac aaggccaatc gtccaaagcg taataaccag 30240 taaacgcaaa attcgtaagg ctataaattt tgagtgctgt agaggcgaaa cgataaaagg 30300 cagtgagatc atgactgtga gtgagactga tgccgccagc aaggtgtata acaatgacca 30360 tgatttaaca taggcggaaa aagcgatcat taaacaaatc agaatgatga gcggtgcatt 30420 gcttttcatc atgcccgtgc taattttcat tcttttgggg ctccattttg tacgagtttt 30480 gagagactgc gtttgtaatc atccgctgcc ttagaaaagt taccgtcatt ctgtaccggc 30540 gtaaagcgaa tgccaaaaaa cgcctcaatg acggaggaaa gcgtcactat cggtcctgac 30600 gaggcatggg cttttcgctc ccgagcctca cgctccgcaa agtggatcac cggtccccta 30660 gaaaatgaga gtgagtcatg ggaagaccag tctgtttata gccacagtag ttaaacgcac 30720 cccgccagtc cgtcgctgtt tgacatcatg gccgcgaatt aggttaacgt cgcccggtat 30780 agtgtaatcc caggctgaac ctgtgtttgc agctggtggc cctgcatcca tcaccatgac 30840 aggcgctggc cgcaggaatc gcgtgccgga tgaagggtat ccactatacc gggtgaatga 30900 tatgttgatc cacgctgacg ggtagtttta tgagcaaacc cgcagcgagt ggcaggcctg 30960 tgtcattcgc agttttactg atgggacgga aggttatcca caaaaacggt gaataaccct 31020 gtgaccggaa tctggataat catcattgcg gcgacaacaa cagaaagaag tggcccggac 31080 ttggccaccc taccctgctt ttacttcagt tcctctatat tcagcataaa ttcagaagtt 31140 ccaacgacgc cggaagtcga aggaaaaata gggaagctgc ggctgtcacc cagacccaga 31200 tccaactgaa catttttgct ctccccagga gctgcggaaa ccccattcac cgtgacgccg 31260 aaggctgcat ccttacgcac cgtcagtatc gcgtcctgtt tcccggttgc gatagacccg 31320 tccttcttac gcagctggct ggcataaaga accgccagcg gtgtgtcatc ggacgttttc 31380 agcgcggtac taacggagat ggtcttaagg ttttccagac gaaccaggtt gttcggcaag 31440 taactaaatt cgacggcgct ttctttaacg ttgttcatct cgtctttggc ctgcacggta 31500 agcgtgtaag tttcgccgtc gttaagtgaa ggaaagatct tcgggtaatt cggggcataa 31560 agattatttc cgaggtttac ccacgacaac tcaacagcat cagataccgg gccaccgcga 31620 agcgtcattc gcgttaaaga gggcttggtc agggtatctg cgagctgaat acgaatgttc 31680 tccagtccat acaccgttac actgctggtg ataggtttgg tttcgtagct gatactgatg 31740 gacggcggcg tgttatcgac cgtcacagtc ttatagtcca gactacccgt attgttgaac 31800 gaatcctggg cgttgagctg cacgttatag ctgccctccg ggattagttt caggttgaac 31860 tcgtatgtat aattcccggt tgctgtgtta cgccccgtta gtgttccggt cacattgata 31920 tccgcgttat tgcgggattt gtcggacagc cacacccggc tcagtttaac ggtatcgaaa 31980 tacgatccgt ctcccggctg gttgatgtaa acctgaagga tgttggtcgt atcattgtag 32040 tcatagccag tgaccgaagg ccccagcgta tgccagacga cgttttccca gataggcatg 32100 aagaaggtgg attctgttgt ggaacgtacc tcataaccac tatgcagata gccggtggtg 32160 ccgtttgtaa tcgcctgtgt cagggcgacg gtacacgacg ttgacccggc agggatgttg 32220 caggtggcac cgccagtaat tttttggtcg tagggccttg cctgcacatt gaaacggatc 32280 tgggtcaggt tcaccggcat atctgaagcc ttgaagtatt tccaattgac gctgttaaac 32340 caggtaccat cggacatctg tcgctcaatc gccggactcc cccatgcagg actttttacc 32400 gaagccgggt cccagttcag ccaggaggcg tattgagtca gatcgcctcc ggaccattgg 32460 tacgtgttca ctgggcgata gtagtttata tccagagcgc cctggggaag cttcacctcg 32520 acgtacacat aggtcgtgtc ttctgaaata accttagcac cgccataatt gttaagaatg 32580 gtgatgccgc cgttacggta tggcttccag ttggttcggg ggatacggat gaccatacgg 32640 tatgggtttt cgagtacaga tagcccccga acaaacggga cgtaccctga agagatcccc 32700 gggaccacac tcgtactgac gcgtgagtca tgaaccgcaa agggggtgta ttcacctatc 32760 tggtcatcaa ataaaaagcg ctgcggcgga atattcagcg tgtttccggc tttatctgtg 32820 atgataaaat tgaaggtaaa ttcttcattg agatcgctgg tgggcatacc gggttgagtg 32880 accgagtcct tgatccaggg gtaaaaggca cgttttgccg ccgtatcgta actgagtgtg 32940 ttgtcggaca cgactgtgcc atttccgcgc ttgatgacca gacggatctt gtctatgcca 33000 ttcgcatcat caactccatc agcaaagatg gaaaactggc cagatcctcc gcgcccaagc 33060 ccccaaactg ggccactcag gaccatttca tagcctgcgt tctggctcgg gtagatgctg 33120 gtatactttg gcgctgtagt gtcgattgtg aaatgatacg ttgaagagct gacgacagcc 33180 tgctggagat ccagagtatc gttgatgacg gtgaaggccc cttcaccgag tgcgggtaac 33240 gccaagtcct ttccgtaata ttccgtgccg tctgcggcaa caatgcgatc tgcgacgctt 33300 atctttcctg tcactgcgga atacatgacc tttttgtcac tgtccctggt cacactcact 33360 cgttcgtatc ggtcaaggcc ggagatcaga ttcagggtca ttgtgcttgc cggattaagg 33420 tagctctgcg tggcaggctt aagcgtcttt gccagctgat tggtgtcagt atacgaatag 33480 ctgaaaatct gagccgccgc cggataaact gaagctatgg ccgtggcaat gatacagcct 33540 gtcagaattt tacgcatgtg atactcccgg gatgtatttg cccctatttt acgaaatctt 33600 ttcacctggg cttgctggtt agccggggta tttcacggca taaaactttt aaatgttgcc 33660 gtgatagcaa tgttgtcggg tcagaacaaa acgaaagtta aggcaacttc aacagggctg 33720 attacggtgg aagaaaagta acttttctct tgagaagaaa taggaaaagc agaaattagg 33780 acgattaaat gaggtgaaat gtcagcaaca ggcgatgatt gtccatcatc gtaagggagg 33840 gtacagggtg ccgctgcctt actggcatca tgttgatgtc cagctcttca tacccgtttg 33900 taccttagcc ggaactgttg ttcagtacag gtaaaagttg taataactcc ccgctcactg 33960 ccggggagtc attttaaatc agcacggcgc catcagaata gattagcttt caaaccaggg 34020 cgaatcggca gagttcgcag attcttcact ttgctgtgac tctcccagaa attgcacttc 34080 acgtactggt ttacttttcc ccaggctccg ctggaaatca tccatcacaa actcaatatc 34140 atcacggtcc tcaggcaaga caggcgaact tttggacata gtctttcctt cagttaaaag 34200 cgttctgcat acagaacgcg gacggagacg gcagtgttgt caaactcatt atcgaaggta 34260 tccatccact cggtcctgaa cccctcgccc agcaggttat cgatcccctg aagggacaga 34320 ggcaggacgg cagctaaacg cccgccggga accagatgag acgcagcggc cagcagatgc 34380 agcttagccc ggttgtcagc aaaaggaggg ttcatcacca cgcaatcaaa tttctgaatc 34440 tgattcgccg ccgaccaggc cagaaaatcg gcttccgtgg tctcgtaacc tttagcccgg 34500 gagaccagac aattcagtgt atccagttcg atgccggtta cgttgacact tttcgggaaa 34560 cattgaagca aatccccgtg cccaatattg ggctccagca gccgttcccc ctccccggcc 34620 gcaataatgg atgcgacgta ttcactgagt cgcgccgacg acggataaaa ctggtgggat 34680 ttaatatcag gcatggcgcc catatgtccg atgaagcgca tcacttcggt cgggtcataa 34740 tcaaacgtca catggtagct tgtcactcgg gcaccgagaa atcgcagaac atccgcgttc 34800 acctgccgcg ttttatcagc gttctcaccg gcatagccga gcgatgtcca gctggaccat 34860 tccttttcat tctgggtaaa atccagctct gcaagctgca tccgtgaatg aaaatcgatg 34920 cagcgtttca gtgccgggaa ctcctgcaac gtcgctttgg tatgggccac gcgttcagca 34980 ggcagagcca gagggacgat ggcagcaaga atgttgttaa gccgttcggc gatatcagga 35040 tgcacatcaa tgtgcatcga tccgtttttg tagacccgaa aacgaatact gttgccatcc 35100 aggctgatcc agtttctgaa tccaacatga ccaaccatat tctcaaccat ttttttcgtg 35160 tcatagaccg gtttaactgt ttcgccccgg aaataagaac agatcacccg caactccgaa 35220 agtggcatga ggccggattc tttaaactca accttcagtt ttacccattt gtctttcacg 35280 ccttcacata cgccggaggt gatcatgcga gtagagaagc caaatgcttt attggttttg 35340 tgttgacggc ttaatgactg aaagacggca tagacacgat ctttaatgaa ctgatgccgg 35400 tcattgagca acgcgacaac cgtggtaaca acagcatcga gtgtaaaatc agggatctcc 35460 tgaggaggaa ggtggtaacg gtcagcagta aactgcttat cccattcttt cttcttttcg 35520 tcagacatca cagacagtac atcggtcagg gccatgaccc tcttccagta ttctgaacgc 35580 agcgcgtttt ctgcgtagct ggcatccgct tctgaaatga gatgattgta tccggagagg 35640 tatgaataga gcttctgatt cccgcatttc aggaactgag cggacatgga cctcagtaag 35700 ctaagctcat cgttatatga ttcgacctgc ctgttaatga catcgagctc ttcccgcatt 35760 tcgggcagga agttatcgtc gttaataagg aggccagtat gaggcatata agcaaccaga 35820 gaactcccag gggcacccat tggcagggaa tcagattcaa cagcagacat agcaccagtc 35880 ctttttgaag ggtttatctg ataccaggat aacaaccttg aacaaaaagc taataggttg 35940 gctgacatga aaatggagaa attaacactg cggaaagtca gaaagacaga tgtggtttta 36000 atcagaagaa acgggccgga gacaggacaa aaaaacccct acatagtagg ggcaacgggg 36060 ggagagcctg ggtggctcgc tctaaaatat cgtacttctt attgtagtct tctcacactc 36120 tgaaataatt catttaagcc tgtgctgggg gtgtttcgga ttgcggttct ccgccatttt 36180 tatcgttttt cttggttttg taagtcactt tttccccttt caatcgggct tgccgatttt 36240 cggcccggcg aagctgcttg ttttctgatt ccgtaatctc actttgcagg ttcttgagca 36300 tctccagcat gctccggttc agcgtaaagg taatttcttc atcttcgctg gagtcggtca 36360 cctccggcaa ctcgatatca ccgagtttct gcaatagact cgtcgtaatg agtttgaccc 36420 cttcgacggc ttttgtagcg agaactggtg gaacacgtgc gggtttaaaa tcggaaggga 36480 caacacggat ctgcccgcgt ggcgttttct taatctggat accgcttgaa tcagcctttt 36540 caaggtctgc gatcatcttt tcgatccgcg caacagcttc cgtttcaccg aactcatcga 36600 taagggacag gactgctaca taggaaatgg catcggcatg gatcagtttt ttgagataga 36660 cacagcagcc ggttaaacga ataagagcag caattgtggt attacttttt ccctcacgtt 36720 cggcaatacg gtcaagcgac catccaccca gcgcctgaag acgtcggtag gattcaccca 36780 aagccacagg agaaagagcc aggccacggt ttccgtcaat cgttgtcaat tcgcagctga 36840 tctcatcggc tttcatctcg atgcaaagaa tggtgaggtt agaatgccct tctgccacag 36900 ccatcaaagc agcctttaaa cggcaatgtc cctggcgaac gtacggaatg ccgtctttga 36960 tcagaacgcg gatagggtct acgtaatcac cccggatgta cgcattcttg atgttattga 37020 gatgatcggc gacttctggc aactggtaat aagcttcccc cattcccatc tcacgggagt 37080 tgaatccttc cgtgatttga accacggttg ggctgatagc ccatgctttc tgttcagtga 37140 cttcattaca aaggtcaggg ttcgcgtcgc ggaactgctt cataccactg acgaatcggc 37200 cggaaccggt cactgttgaa aaagacacga gtggggattt aaagacccgt gagttagttt 37260 gctgttggga atcagtcatc agatcactca tagatactcc gttgaattct tttttgtcat 37320 acctttcatc tgtgcgtgaa tactaccgga aaaaaaaatc tcactttttc gttaaaaagg 37380 tactttttgg gtctattccg aattgaacga ggaaaattgt tctggcgatc agaacaaaaa 37440 gaaaaaataa ctcaaataaa acagatggtt atggttaatt cgtaaaggat aaactttttt 37500 ctgagaagtg aaaaaaaatt aaaaaatgtg tcgaaatgac aatctcgtta acaaaagcca 37560 cgttttttcc tgctcatacc ttattggtag caatccgcct ttcggtacca taagtgtggc 37620 ataccgataa agctgaacgg agaagactcg ttgcgaaaac atacaccaat catcaaatgg 37680 gcggggggta aaaccaaact gatgccgttc ctcagtaagc acttcccaca tgataagagc 37740 cgacgctggg ttgaaccgtt tatcggcggt ggcgccgtgt ttctgaacat gtttgccacc 37800 gaggctctcc tagcagacag caacccggac ctaatcaatc tgtaccgcaa catacagcga 37860 aataaaccgg cattcatcag agaagtgcag ctgctggcgg aaaggcattt tgaagaagag 37920 gattactacg tgctgcgtaa tacctttaac agcaccagtt ttgatgatgc cccgctacaa 37980 cgagcagcca ttttctacgc gatgaatcga ctcggatata acggtctgtg tcgttacaac 38040 ctgaagcgaa agttctcagt tccatgggga aagcgatacc agttcagtct ggatatccag 38100 aaggttgatt acctctcatt caggctttcg agcgttgaat tgaaaaccgc agattttggt 38160 cagacgctgg agtttgcagg tggtggtgac caaatatatt gcgatccgcc atatgacaaa 38220 atcagtaaaa ccagctttgt aagctatgat ggtataccgt tcgataagag cgcacatgtt 38280 aaactggcgg atatgctggt ggatgctaat cgtaaagggg cctcagtggc catatccaac 38340 agcatgactc cctttacgct ggagctctat gaagaacgcg gttttgatat tcatactcac 38400 aacgcttatc ggtctgtcgg cagtcaatca aagtcgcgta agaaggaaat agaaattctg 38460 gccgtccttc gttgagcggc gatcagtagt tagtcgatcg ggcttatcca ttcctcgaag 38520 ctcagcactt cggaatggtc acggctggca tagggaataa actgaagctc ttcaattgat 38580 cgctcccctc tcttaccttc gcatataaac gatatgaacc cctgatctgc aagttgggta 38640 aggacattca tgattcgtac gttcactgta tgcaactgaa gatcattcac gatatcggta 38700 attttgtgtg aatggcgccg ggactttcgc aaataatcaa agatgacaaa ctgggcattc 38760 cgtcgcttca ataatttttc cgtcataaat tcctgaatta atccccccag caacatcagg 38820 aacggacgaa gtaccccagg gaacgttaac gtataagact gcgatgtttt gaccagagtg 38880 aaggacgtca ggaagctgaa gtttagtcgc ttctttgaat acgggacata aacagccaat 38940 gtcgtagaca agtaagtaag caattcttcc agatgagcgc gtgtgatcat gaccgtctta 39000 tcgctattac gaagaccgtg ataatcaata aatgccactc tggcacgact cagccactcg 39060 tgaatgctta tggatacagt gaacggtgcg ttttcatcgg cagaaatgac gccgtgctca 39120 gcgagttggt tatggataag catagacagc tggtaaaatg gaaaacggca ggatggatga 39180 cactgtaggc cagttagcgt tagctttgca ttatccaagt catcgagcgg aaaagtaact 39240 tttcgggaaa taatttttgc tgacgttctt gctgacttgc ggatgaaccc aagtccaaga 39300 tcattttgca tatatcactc cgttttaaca aaatctcctt aacctatatg ttaagaagag 39360 acaaaaaatt aaaaaatata attaataaga ttatcatttt taatttaaaa gattagttaa 39420 taacgggtgt tgaatttaaa ataaatcggc ttattttcgg agtgtaaaac cgggtaaaaa 39480 cccgatgcgt gagcaacaga tttgacgtga gtgagtcggc acgacagtgc agaaagccgg 39540 tggctaatgt aaaaacggcc tgtatttggg agttccggtc actagacacc aggctatgct 39600 gttaatttaa acacagtcag taatgcgtag ggcactgagt caaagtagtg gatctttctc 39660 acttttcccg aaagatgata gctatgcccc aataaaacgt gatcctgaac attaccagtc 39720 aacgcgaatc catcattctg ctttttgcct gtaaaagtaa aaaaatagct atgagaacct 39780 tttgaaaacg cagctcgcac ttctgtaaaa ataatatcaa aactaactac atcaccaatg 39840 ttgaaagaat gttcaattgg aaaaccggcg ttttctgaaa aagcttcaga aacaggctgg 39900 tatgtcgagt agaaagactc caactgacgg actgttaaaa agagattgtt gtttaactgc 39960 tgtgcaatgc ttgctgcaaa cttagaattg tcagcttgca gcaatgctaa ctgctcgctg 40020 tgcctacgtt tccaggcttc aagatcggga ttgcagcgaa gttccgggat agtttcaagg 40080 aattcaatgc actctttcag taccagcttt tcctctgtgg ctggagacgt tttggagcca 40140 ttgcatgtca cacagacggc gttcgcaatc tttccagtcc ctccgcattc aaagcactca 40200 cgggtgataa cggcgtaata gtgtccatct ttaccgtaga taggctttac ggatgatggc 40260 agtaaataac catcctgagt aaaaaaaaga gaatgtttca ttttttaagg ttctccagtc 40320 gagcctccac gagctgtaaa gcgtcagtta ccttctgtac gtattgatcg tgcccttctt 40380 caaaatgatc aaaacgcttt ccagccttga tctcttcaat gttgcgatcg agtgtgcctt 40440 ttgtaataag tagatcgtta taagtattaa ttacagtaaa ctgtgcaatc ttgtccataa 40500 acggtcctta gcattctact cacttgttaa caggtcacga atttcatgca gttctgtaac 40560 cttagatttt ggaatgatga tagcagtatt ttcatcattc agaaggctta ataaaagctg 40620 gagttttgct tcatctagag tgatctttac actttccgtt gtctttgtga tggaagtgct 40680 gctgatgttc gtaaataaat tggaatgttg tccgtcgaaa attaattcgg tgagtttatt 40740 actgtcgttt agtgctggcc gtacagtatc aatcagcccg ataaattcag tttttaagcg 40800 ttcagttttt ttatgagaaa gccgtttaat acccaatgaa ctgcgagtga tggattttgt 40860 tttaacttcc ttaggaataa catgaacagg gagtgtttcc gggttatcta gtttctcatc 40920 gtttgatgat gtttgaacgc ttgatgtctt agataaaaca ggttctggtt cagttgatgg 40980 tactaaaaga gaacacgatt ccaaatgtgc aaggactttt gcatggtcat tggaatactt 41040 caacatgatc tcaatcgcga gtgttttttt aatcaggttt agactgatta aacgttgtag 41100 ttctaaaggc atatcaagga ttttaagctg gttacgaata gcagtgctag accgttgata 41160 gcgcatagca agggattcaa cggtagagcc aagcttcagc gcctctgcca gtgcataagc 41220 taaggctacg ggattaagac cgttattcct attcccatca aggttctcca ggtattcttc 41280 acttttattc ttatagttca taacaactac tgaaatgagc tgaatatcag ctccttccgc 41340 aagagcaaga gatagtgctc tgtaacggca atgcccctgc cttacaacgt aattggagtc 41400 tttcttaaca accttaatta aatcgactcg tctgccctct ttataggctt gtttaataga 41460 aacaatggtc gattttactg gttcctgttc ataacaaagt tcaccaatta ccgcttcacg 41520 tggattgaat ccagattcga taaaaagtgc tttaggactg atctcaataa tctgatagtc 41580 gcagtgattc atataacctc ctttttatta catgatacat taattgactc agtttcaaat 41640 aacccaaaag caaaaaacaa ttaattcggt gcttgactgt aattttagtt atgaaggaat 41700 taggccattt taatttgaaa tttttaaatc tgaatggttt gaaattaata tatcttaaaa 41760 gcttaagatt gattgatact tcttccggct gcattcccta cttggctaga gtccgaacct 41820 gaacttttta ggtcagagtt ggttaacaga cggaatttat ccacgttttc cacaagttag 41880 atcaattctt tagatcaaga gagatcaaga gagtacaaaa aagatcacag gttccgtaaa 41940 tgactgattt tattatggaa taagcatgat caggcattca ggtgcatgta aaaagcattt 42000 gattgaataa gaaaagcatt tacttgaatt gaaaaggcat ttagtttaat gcgagaaaag 42060 catttgcacg aataatctat tcacatctaa atgtatcaag ggataaacca tggtgggtaa 42120 atttaaatga gtgataacaa tgaggtaaca catccttttg atgtgaccaa cacggagaca 42180 gggaagactt atcaactgag tccaaactct tcgaaatcgg tccaacccat tgctttactg 42240 cgcttaagtg tttttacccc ggtgggaact aaagagaagc gatacagaaa ttttgaggtt 42300 gacgcttctg atgagttgtc gagcatggag ctggcccgtt cagaaggata cgatgacatt 42360 cggatcactg gtcttaagct ttcgatgtca accgatttta agtgttggct cggttgcata 42420 atggcgttca gcaaatatgg tttcgcttcc gataaaatca cattgtcatt caatgagttt 42480 gcaaaaatgt gtggtatcag ttctacaaac ataaacaagc gaactcgctc acgatttcag 42540 gaggcgctag caaacctagc ttccgttgtg atttctttcc gtgattcaaa aactgaacgt 42600 tttactgtca cgcaccttgt gcagaaagca gtgattgatc ctaagaagga caccgtagag 42660 ttggtgggcg atccctcaat gtgggagctt taccggtatg atcataaaac cttacttagt 42720 ttgcaggtgc tttcggttct cgctaaaaaa gaggcagcac aaagcctgta catatatttt 42780 gaggcgatgc ctgccggtac gttattcgta agcatgaagc gtttgcgtga gcgacttctg 42840 ttgacgactc ctgtacgaac tcaaaaccag atcatcagga aggcgatgct ggagttaaaa 42900 tcaataggat atcttgaata tcaagaggtt aagaaaggta gagatatcca gttccagatt 42960 tttaaaagaa gtccaaaact tgctctggca aaacacagtt gatgctccgg gtatagtacg 43020 cacaaaagtt actttggatg taatgaggag tatgggcatt catccaaatg ctttttaatg 43080 tttctccgga tttgaacacc cttccctgtt tccaaacttc ctatcatttc tgatacccgg 43140 gttcttctgg tattcgttcg aatgcttttc agaaaaaatc atgcttgcta gttgagacaa 43200 cgtaacctat tcattttgct agtttaataa gactcattca tacatatgcc tttaactaca 43260 ctaccctcca tcgtgttgta ttgggcttta aacgcaaatc cctatactcc ttgtgccact 43320 cggcgtattt acagttcctt aacgcctgca aacgactggg atatgagcct ggtcgacggc 43380 attttatgaa tatgcaggcc aatgaaggac ctagagaaat aacataacat tctgataata 43440 aatgaaaatt actcaaattg gatatcaagg agatgaaagg catttgtttc aatggagagc 43500 aaaaaagtgc cttttgtata aaagcatttg ctccaatggc ggcagaaaag tgccttttgt 43560 ataaaagcat ttgcttcaat ggcggcagaa aagtgccttt tgaaaaaagc atttgtatga 43620 atgctgcggt gaaagttgct tttggtcggg aagcagggct cgcaagggac agtgtaaggt 43680 gcctttgttc gaaaagcatt tgcacgaata ggagaatgca agttgccttt ggtcggaaag 43740 catttgaatg aatggggaag tgtaagttgc ctttggttgg aaagcatttg catgaatgag 43800 tccctgatag gtgtctttgt ttgaaaagca tttgcatgaa tggattcaga agaagtgact 43860 tttacgataa gcatttgaat gaatgggcac cgcagacgcg cattccccaa tcagcatttg 43920 aatgaatgag ctccgcagtt ttgctttcat cgaacagcat tcgtatgaat gtgctccgca 43980 gaggtggctt tcattgaaaa gcatttgtat gaatggggga tacataatcc ttgtgggtga 44040 aaagcactcg catcaatggg ggaaaagtga cttttggaat gtcatcctta ccgtgtcctt 44100 tgttaaatat ctggctggat gaatgccata aaaatggtaa aggggcagac gatgcccctc 44160 ttccctattt ggcatgttaa ttaaacgcac cttctttaat ccgattacat gcgggattct 44220 tttctgacat tcgatggcta aaaaaacacc aagcgcaatt aagtcaaaaa aaaggtggtt 44280 aacagaaaaa tgaaagaaaa ataaaaagta ttatgccaat gcgttttcgt gaattcaaat 44340 caacacggag taattatgga actgacattg aatactaacg ttgaaagagg aaaaactaac 44400 gcttttgcat ttttgaagtc caaacatgca aaagtgcctt tgtttattct cttggtttta 44460 gcaaattgca gttttgcgta cgcgggttcc gatgatggag ccttcggcga tatctgggcc 44520 tacatgagcg aagccttgac tggtgcgccg ggtaaaatca tcgcgtgcgg catgttgttc 44580 tcggtggctt atttcggcgt tgtaaaacct aaccttggtt tggcgctggt atcagcatta 44640 atgatgctgg ttatggcaaa cggtgaaaaa attatcagct cgttcctgga tgctggtatt 44700 cctctgtgat ttgttagaac aataacaatg agggggatat tccccctctc tggagttttt 44760 atgacaagcc agtacgagat accgccacat acatatcgct ttccatacag aataaatatg 44820 ccgttactaa ttctattctg ggatgcaaag caattgggta taacattcgt gactatcgcg 44880 agcggtaata tttttgattt ctttataact tcggtagttg tggcggtggt gttctggttt 44940 gcatataaga aagcagcaga ggaagggatt agaggaaaac taaaacacaa actgtggtgg 45000 tacggctttt ttcctggaaa atcggtgttt agtagtcgtt actttaccga tccatttatc 45060 agaaacctct attcttgatg gagctaagaa tgaaacttct cagcaggtta aaaattccat 45120 tcattaaaaa ttccagtaat ggcgattttg ataacaagga tgagacttcg caaaaaggag 45180 gtgaagaagt aaaaggaagt tttctggatt caaaagcacg ctttagtaaa gaaattgaag 45240 gttctgaaat tggaattaca tatagtgcat tgattaaacg cgacgaaaaa ctcctacgtg 45300 tgaatacagt tgcaatgatc attattgggg ttctggttgt aaaaaatcaa tttctcactg 45360 atcctgtgac tatagtgcta ccgccaaata tgacggaaga agtcaaagtt gttggaaata 45420 aagcctcaga atcatataaa acgcagtggg ccttattctt tagtactttg attggaaaca 45480 taaacccaac aaacatcggt tttgttacaa caactatatt ggatgcgctt tctccggatt 45540 tacaggcaaa gacccgggaa tcactacagc agcaaaccaa tataatgcag gctcgtggtg 45600 tagagcagtc atttaagccg atcgatatgt attacgacac caaaaatgac atggtctatg 45660 tctggggaac aaagtcaact cgtttgatta atgttccgga caaaactgaa tcatccaaat 45720 ggacgtttga atgggtcctg ggaatgaaaa atggacgacc gcgcatagcc tatgtgaacc 45780 agtattcagg tacaccaaat attaagaaaa ttacaatcaa cggcaaagaa caactggcaa 45840 cactcgataa tccgccgccg tcaataggta actaattatg acttcaaaaa aggtttttca 45900 ctgcaccgcg attacagcag tgattttgct ggcaacttcg aatgtggtat ttgctgaaga 45960 ctatcagtta ccggcgacag taaataatcc ggtagttatg cctgtcgggg ccgatgaatt 46020 tcagaacggt gtgaaaaatg cgataattaa agacactggc actacgactg agaccgtaca 46080 agcaacaaaa ccgacaactg ctctgccaag tctttcacct gcaagcagtg cttctcccgc 46140 agtcaatgaa ataaccgggg cgttgtcaaa taaccctact ctagctggtt accagcaaca 46200 ggttaaatca ggaaattttg atagttacgg aagaccagca gggaaagaac ctcaacaaaa 46260 tgcacaaagt accgggtccc cttcaaaggc agatgaactt tatgttgaag cacgtaatcg 46320 ctataaagaa gtacaacgag taaacgttcc gcctggtggc aatattgtac tcccggtttc 46380 tcgggggctg caaaacagaa tttcgacttc atttaaaaat gcatctgtaa gtacttcaac 46440 gccagctgat gaagccagta ttttcgttaa tggcggggat gtttttattt caacaaatac 46500 agataagcct ataggaatta tgctttcaga agattcagtt cctgaatcta cttataacct 46560 gacactggtt ccactggatg taccaggggc catgatttca gtaacaactt ctttgagccc 46620 gacaatgcag gcaaaacgag aaacttctct tgataaacaa aattatgatg agatgctggc 46680 acgctcacaa tcagaagagt tgactccttc agaccctcgg caggatgacc ataaacagcg 46740 gatcattgat ttgttgactc cggttgcact gggtgaggtt ccttctggtt tcagtttaca 46800 agaagaccgc ttgtcacgca taccaagctc agagcagtcc ccatgtaatt tcaatatgta 46860 cgccaagtta ggtcaaagac tggtgggatc tcgggaattg atagatgtcg ttcttgttaa 46920 gaatgataag ccttacggac aggtagtggc tgatcagcaa tgtataactg aaggcgtggt 46980 tgcaagcgct ctattcgata aagcattcct tcagcccggg gaagagaccg aactttatat 47040 tgtgcgggat aaattattta aagagcgtca gactcgtgtt actacgcgcc caagcctgat 47100 taaaagataa tatgagaaaa gctacttttc ttacagtgat ctcgtttggt ttagttgtct 47160 ttttgggtac cagttattac taccaaacta agtatatccc gaaaggcacc gtgaatatat 47220 ttcctgatgt ccaccgacag ggtgagatcg ttgatgatgc ctttgagaaa agcacgattg 47280 ttataagcga cccaacgctt gcggataaat ttgttggaag ttcaaccgag tctgtcggtc 47340 ggcatgaagt taatgtaata aaagaattgg gcacgcaaaa taatggttcg aaatttattc 47400 atgatgagtc tgataaatca ggtttgacgg ttggagataa atggcctagg gctggtgaac 47460 cttatatcgt gcctcagatg acagaatacg agcggaattt gaaagttaag cgattccagc 47520 aaccaaagaa tggagttaat aatggacatt aaaaaggcct gggaaaataa aactgtcaga 47580 atctcagtaa ttggtgctgc attgatggta ttgattgttg tcatcagtca atcaatcttt 47640 accacaccag ttaaaaaaga gaagaaaacc cagaaaaaag atatgcaaac tggattcctt 47700 attgatgatt cacaaatgaa caagctgagt aatgaggaaa gccagaagac ttataacgaa 47760 atggtaaggc agaaccgtat tgaccagaac gctgccaagg ctgaccgtga caaagctgaa 47820 aaggctcagc aagaaaacaa agcacagata gccagtcttg cttcgcaagt tcagcaactc 47880 actacgcagt tgactgaaat gcagacctca agaaatggta atcgcaatct cgatgcaggc 47940 ggaccacgca acaacgtcaa tgaacaagcc ccagcaaagc cataccagct taatccaaat 48000 gcagcggtga acggggttag ttctggatac gcacctatat ctccgacccg aaacagtcca 48060 atgcggacaa taacacagag ttcaattaag acaaacggca ctgatggtgt cattcaggtg 48120 atgccgatat cagagaaccg gatcagagag gggcgcgagg ttgttgcggg aagtgaaaag 48180 gccccaacgc gaactattcg cggcgatggg actgcacctg ttgatagtaa agctcgtcat 48240 gcggcccgta aggatgaaat gtttcttcca gcgacgtcaa ttattactgg ggtgctaatt 48300 accgggctgg aagctccaac gagtttgtcc tctaaagcag aaccgatgcc ggttaccatg 48360 cgcattaaaa aagacatcat catgcctaac aattacacga tggatttgcg tgattgtaat 48420 ttattgggtt ctgctgtggg ggatctggca tctcagcgtg cgtacattag ggcaacctcc 48480 atatcgtgtg tcaactcgaa aggaaaagca ttcgacgtaa tagtggaagc ttatgcggtt 48540 agtgaaaatg acgggaaaaa tggcattcgt gggaatctga taagcagaaa tggaaatgcg 48600 attgcaggtt ctgcgtttgc aggagggctg tcagcattgg cggggagtct gagtccatca 48660 aaggtgtctt cgcttaatat agatccaaac tctacggcac aataccaatc gccaaacata 48720 ggtgcattag gagcgctggc cggagccggt gcagctcagg ggggtctaaa ccgtcttgtg 48780 gactactata cgtcaatagc tgagcagcag tggccaattg tagaaattag cccagggcgc 48840 ccaattactt ttgtcgttca aaaaggggcg acaataccta caaacctgac aagccgctga 48900 gaataattat ggaaaataac aacgacaatg aatcaccaaa aaagagtgag tctgctgata 48960 gcttaaatat cgacgcggct aaaccggttg ggggtatacg tactaccaaa aaagtaactt 49020 tagagatcga tatcgagaaa actcttaagt atctgatggt cgcaggcctg gcagttctta 49080 tcgtgatcta tggatacaag ggtggacgtt ttgtatatga caacttcaaa gcaatgtcgc 49140 aaccggccta ccagattgcc gtgctggata tgcaaacttt aagaaaagta tttaataagc 49200 aaaatccggt gttggattcg cagcaatcca aaactaactt tgaaaattat tttaaggcat 49260 taatgaaggt ttaccgtgaa cgtggctatt tggttattga tgcatccttg gcagtaacta 49320 ttccagagaa tgttgaaata gtctcttata tcgaccttgg tggaagtttt ggtgaggtac 49380 aatctcttcc aggcgaacct aaagaaagtg agattcgata attgaaaaag ttacttttgt 49440 ctctgctgat ttccattacc tcagcgtgcc cgccgcttac tctggctgtt gaaaatgtat 49500 taaacaatcg tgatgccgct gcgttaatgg aaaaggcaaa agaaggtgga gtatcaacga 49560 aacctttaga cggtgtattg gcgaaaatga aaagctataa gcctaaagat gctatttaca 49620 tccctactgg cggtctttat ttgttccagg atgaacgttc tcagttgatg gcggtgacca 49680 ctgacggacg gtatacaatc acggggggga gcgtcatgga cattcttcag agaaagtcag 49740 tgttatcagt agaggatata cgaaagtcgt tctttattaa tttagacgac gcccctttcc 49800 ctcttgaaac tgtggcatcg atacctttag gaaacccaaa actcaaacgt caagcggcaa 49860 tatttattac gcttgattgt gacggttgtc aggatttaat aaagaaattc tatgatgaac 49920 gcgaaaagta tcgggtcgat atagttttaa tcccctcccc cggcgagcca aagcaggaat 49980 tgcgtcaatt atggtgcagt aaagaaaaag gcaaagtgaa tgatcttgat atcttgcgtt 50040 ggcttatggg taataaggcc gatatagaaa aacgactcct gacgaaagaa gaggcagaag 50100 catgtccggc tgaaccgtta gtcgcgtcat taatgctggc tggcatttat aaattacagg 50160 gagtcccctc agttgtaaga caggatggac tcgctggtaa tggcataccg aaagattttg 50220 attactggtt aaaacaaagt gtcgaaccct tactcaaaaa cccatttgat actaattaag 50280 gtaatgaaat gaacattaaa aaagttattt tcagcgctct ggttgttggt tcatcttcat 50340 acctggcggg ttgtactatt ggcagcgcag aatctgaatg cccgggaatt gaaaaaggag 50400 ttatttgtaa aggcccgcgt gaagttatgg aactgacgaa caatcgtgat gatctctccg 50460 gccttgggga ggaagaggct aattcgggaa aggggaaatc ggctgtcaat gacagccagt 50520 accctgccca actaacgccg cctggcgcag tgcagtaccc caagtcgtct gtacttgtta 50580 ataagccagt gacatacaca acgacggaag taaaaccggt tggacagctc ccggtgatgt 50640 atgatcagac attaaaaatg ggggcgccaa cttcaacaat tggaccacgg ccaatcagcg 50700 ggaatcctgt taattctaat gtacggatga caacgagtta caactcaaat gggtcatccg 50760 ttaacccctt tttgcatccg tctgctgaag tcgtgaaaaa aacaactcag gttgttactc 50820 ccgcgcctgc accgcgctat gtagcaccaa attctgatat caatgcaagt aaagaccttt 50880 attccattaa caatggacag ccagtaaacc ctacgctcag ctctgggcag gtacagcaat 50940 accgtacaca aggctacaaa caggcagtcg ttgcaccaga gcctcttgct gtgcttcagc 51000 aaggccgcgt catgagaatc acctttgcac catatacgga tgataatgac gcgctaaatc 51060 tgcctggctt tgtttatgtg aatgtcaaac cgcaaacttg gattgcgggc aaaaattcaa 51120 catcaaatcc ggcacgaatt gttcctttgg aagtccagga tgcggctcgt gaaaatatgc 51180 aacagcaaca gcgagcaacg aaagcagttt cgtcaaacgg tattgtgaga caactctgag 51240 gtcacgaatg agatcagcta acgtctataa taaagaatta agccgtcatc agttaggtgg 51300 atttattccc gtgtatgatc agattccggg tacacattat tttctacttg acggaaaccg 51360 actcggtttt atgtttatct gtagtccgtc gcccggtgtc tttgataatc agcaggatgt 51420 gttaactgaa ttatttaaaa tggacttccc aactgacacc atctgtcaga cctcattaac 51480 tgcgctgcca gacttgatct tgcacttaag tgcctggtct gccgttcgtg gtggtcgaat 51540 ggaaggtcat gataagctta agggggattt actcactgca tatcaactgg attattatga 51600 ccgaagcctg aatgaacctt tgaagccgga ccacgataaa ttgatgcttc gagattttca 51660 ggtctggatt tccttttcaa ttccattgaa gtcagcactt ccttctgaaa tagaaaagag 51720 tcgcattgat gcgctttact ctgacttaat cagtaagttg aatacagtag gccttttccc 51780 acacaaagtt ggtgctgaaa attggcttta ttgcatggat aagttattgc atccgggaaa 51840 aacatcgcgt tggtctgaag gtcatgttga agctagcacc atgagacgcc taaacgagca 51900 gatcaatgta ccgggtcgaa aatatacagt gacagagaat catttctcat ctacaacgca 51960 gagcaatgat atttctgagc atcgttattt caaacaatta tcagtagtga agtttccaga 52020 atttgtaaac tttggctgca tgtatgaact tgtagttaat tggttgaatg gacgtaaaac 52080 gatctttagc cctttcatga taacccagac tgtccatttc gccgatcctt taaaattatc 52140 aagagaaaac gtcagatata aggcaattac taacaaacaa gccagtattc caacagtttt 52200 gacgttttgt ccaagattaa aggatatgga taatgattac atgacgataa cacgcgaact 52260 ggaagatggg gctcgcctcc tacacagtta tctgacattt actgtaatgg ggaattcagc 52320 agttgatgtt cagtctgccg cagaccagtt aaaatcattt tatctggaaa gtcgtgttaa 52380 tgttgctgat gactcgtaca tagtatttcc ctcatttgtt tcaagcctgc cgatgtgtaa 52440 tgacccaaag acaatactag aactggatcg ttttgaggtc gtgagtaata ctggtgctgc 52500 gcacatgacc cccatatttg gtccttggaa aggtaatacg gacagacccg tacttaacct 52560 tgtctcacga gaaggacagc tgttggggct ggatatcttc aagacttctg ccagctataa 52620 catggtcgtt ggtgcaacgt ctggtgctgg taaatcattc tgggtcgcat acatcattaa 52680 taattatcta ggcgcaggtc cgcgttctaa taatctgatc cattatcgag atacttttga 52740 gggattcaaa aacaattctt atgatgcatt tgaccctgat ggagcccaga ttttcgtagt 52800 tgatgtcgga cgctcatacc aaggtatttc ggaacaatat actaatagtc agtttataga 52860 ctttgggaaa aagcctgatt ttacgctaaa tccattcgca tttttgactg atgtgactgt 52920 tggagagcgt gtttttgatg aagcacctgt ctttaatgac gattcaaata atcatgatga 52980 tgataaggat aaagtagccc agaccattat ggttctaaac cagttaaaaa taatggcatc 53040 tgaaaaagga aatattgacg attttcaaca atcggtcatg ctgcaactga ttagtgaaga 53100 atataacgaa tcacgcaaag ttggacgtac aggctctatt actggatttg cgcgacgctg 53160 ttctaaccat gaagataagc gtattaaaga tatcggtgac cagttggggc aatggtgtga 53220 aggagggatt tatgggaatc gctttacaga aaatctcccg ccaataaatt ttgatagccg 53280 gtttattgtt ctggaacttg aagaattgaa ggggacccca caccttcaga ctgtcgttct 53340 gatgtcgatt attcaggccg ctcagcatgc aatgtttatc aagaaagacg gacgccgccg 53400 gttgttcata cttgatgagg catgggagta tatccgtccg gacaatgctt caggttccag 53460 taatcattca aatcaatttt tctcctcttt ccttgaggcc gcttggcgcc gattcaggaa 53520 aacgaactgt gccggtattt gtattactca atcctttgaa gattacttca cctcatcggt 53580 tggtcgcgca ctaacggcta actcgccgtg gaagatcatc atgaagcagg aaaaggaaag 53640 tattgaagcc atgaaggtga acaactactt ctccacaact gatgcggaat atgagcgtat 53700 gaaaaatatt cgaacggtaa agcgtgcatt ttccgagatg ctcgtacgat tcgaaaattt 53760 ccaggagata tgtcgcctct atgtagatag aaaaatggag ctttgcttta cgactgacag 53820 caccgatcgt ggaaaactat gggaaatcca aagccgactt gattgctctt acggcgaagc 53880 aattgagatt ctgtacgaac aggaagttgc gagcaaatca gctgcctgac gttttaagtt 53940 actggttacc tcattttgtt ttgactgagg tatccagtac gtctttgaag taaatagttg 54000 ttagctgtca ttgcctgccc tcccccgaaa taatagcccg ggttaagaat atctagctcg 54060 gattaagtcc tctcaaaccg tcatacatga aattcgatgc ctttgtcatt cttcttttga 54120 aggtgaatga atatgatgaa atttactcca gaattattct ccctaccagg cttttgctgt 54180 gaagttaatc agagcaggta ttatgttttg ggtacaagaa ccaaccaagg gggtgtggtt 54240 tttgtatggc agatacaaac atcattttta cggttataat aaataaccat tatatagatg 54300 aatttgtcgt tttttctttt aagtccttga aataattgga tctaatatct agatgatggt 54360 tgtataaact atacgttaat tagatttgag aatgcaactg ttatgcgatg cgtagatatt 54420 attaaggtga atggtttgtt aaaacaacca aaaaacaagt aagatcaggt cttatctcca 54480 taataactta accatctaac tttctggttg gaataagaaa ccattttaag cttattcaat 54540 aacgaaattt aaccacttga atcgactgac catggtagaa agttggtagg gtaccgtggc 54600 attgagcccc cttaatcgcc agaccatgga gggaagctgg ttgcgtaccg tggcatttaa 54660 cccccttaat cgccagacca tggaggaaag ctgggcgtgt cccatggaat ttaaccccct 54720 taatcgccag accatggagg aaagctggtc gtgtcccgtg gcatttaacc cccttaatcg 54780 ccagaccatg gaggaaagct ggttgcgtac cgtggcattt aaccccctta atcgccagac 54840 catggaggaa agctggtcgt gtcccgtggt atttaacccc cttaatcgcc agaccatggg 54900 gggaagctgg tcgggtactg tggcatttaa ccccttaatc ggcagaccat ggagggatta 54960 ttgccgggta ccaggccatt taaccactta ctcgtctgta cacgatggga tgctggttgc 55020 gtagcgcgga attgctcccc tattcaccag ttctttgcta aaggaaagcc agtctaaaag 55080 gttttccggc caaaactttt tttgtttcac tacagttatt cgcccttccg ttcagcgtga 55140 taaaatatac aaaaacgtag aggtaaccca taaaagtaaa agagcttata gaccagctta 55200 aaaggctcga cccggatgcg tatgtagtag ttgctggatt tgaaaaccag tgtactggac 55260 acgtggctga agcagatacc attaaagaat gcatgacaat tcctgtacga gcggacagca 55320 tgtcaggtga ccgtacgctt gcaaaagatg gatcaccttc agtctagttg agggggggag 55380 atgactaccg cacggaatac ttcgttagtg caatagacga cacggatgaa ttggcctaat 55440 tatacgaatt gccaaaaaac tctcttattg tcaattgtgg gtatgggcaa ttcatattga 55500 ttgccaaata ttttttgggt attcgggatg tcttaacaac aggatttgcc gaatacccta 55560 tttttttgcc aaatatttcg tcattctaag tcgagatcca ggccgaatat cttttaatct 55620 aatccactca atagacagat tctggtggga tacttattgt gtaccgtcgt attaaaccca 55680 cttaaccgct agggcgtcac gttgtcctgt ctgcaagccg aggcaatttc ccctttagcc 55740 aatgaccacg gtgcctgctg gtcgggtacc gtgggattta acccccataa tcgccagacc 55800 atggaggcaa gctggtcggg taccgtggca tttaaccccc ttaatcgcca ggccatgggg 55860 aggctggtcg cgtagcgtgg catttaaccc tttaatcgcc aggacatggg gtcattctgg 55920 tcaggtaccg tggtatttaa ctcccttatt cgccagacca tggggaatgc tggtcgcgta 55980 tcctggcatt taaccccctt aatcgccaga gcatggcggg aagctggccg ggtaccgtgg 56040 gatttaaccc ccttaatcgc cagaccatgg aggaaagctg ggcgtgtccc atggaattta 56100 acccccttaa tcgccagacc atggaggaaa gctggtcgtg tcccgtggca tttaaccccc 56160 ttaatcgcca ggccatgggg aggctggtcg cgtagcgtgg catttaatcc tttaatcgcc 56220 aggctatggg gaagctggtc tcgtagcgtg gcatttaacc cccttaatcg ccagactatg 56280 gggaagcagg tcgcgtagtg tggcatttaa cccccttaat cgccaggcca tggagaagca 56340 ggtcgcgtag cgtggcattt aacctcctta atcgccaggc catggaggaa tgctggtctc 56400 gtaccatggc atttaacccc cttaatcgcc aggctatggg gtaatgctgg tcgggtaccg 56460 tgggatttac cccccttatt gccacatcta tggagtgatc ctgctatgtc ggaagattgg 56520 tattgttgat acttaagagg cttttggaag acttcaatga actgccaatt gaaattcaat 56580 aatgcagata ttccaaaatc taagaaaaga atacagaacg ttagcgtaat aatagaatta 56640 aggttactat taaacgcata acgctaaagt atacgcatta tgcgtaaagt ttacgtatat 56700 acgtttaatt tcactattta ggtaaaaggg atcggaagag aatgaatcta attgataaga 56760 tcgcccttgt cggtcaacgc atgaagagcg agcagatctc tctgaaagag tcattattgg 56820 tctcttcgag ggtttcggta tcggatgata gtgtagacgg tgttgatcgc ctaatctata 56880 accactgctt gaataaaaaa aatctgtcag atttttttgg taaatctcgc gtaactttta 56940 acaaaatctt agcggatctt gaagaaaaag aactggttgg tgctcctatc taccagaaca 57000 aaaaccatct ctatacccgc tgggatgtcc agaaaataat ggatgctctg aactatcctc 57060 gatatagcga ctactactgt agccgtacaa tcgtaacgca gaaccataag ggtggtacgg 57120 ggaagagtac aacttcaggc gttcttgcag ttgcggcagc acttgatttg catctaaacg 57180 cgcggatact gttgatcgaa tgggacccac aagggtctat tggaagcggg atgatccaga 57240 gcgtagcgga agatgatgtt ttcctgactg ctattgacgc catcttaggg gtttacgaag 57300 aagactcaga ttacagaaaa tatcttgatt tagggtactc ggaagaacaa attattgaag 57360 gtatgccttt ttcaacacac cttccgaatc ttgatgttat taccgcattc cctacagatg 57420 cacgtttcaa agataaatac tggcagtgtt ccagagaaga acgaactgag ttattactac 57480 gttttaaaga ggtaatcctg ccggtcttga agagcaagta cgacctgatc attatcgata 57540 ctccaccaga agattcgcca atcacatggg cagcggatga agctgctgat ggcattttgg 57600 ttgccgtttc acctcgtgag tatgattatg cctcaacaac tgatttcatg ttgacgatca 57660 gtgagcgatt caaacaatcg ccgagcaagg gcgaaaatct aagctggttc aaagtgttgg 57720 |