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EBI DbfetchID AL078635; SV 1; linear; genomic DNA; STD; PRO; 42369 BP. XX AC AL078635; XX DT 11-JUN-1999 (Rel. 60, Created) DT 14-NOV-2006 (Rel. 89, Last updated, Version 5) XX DE Amycolatopsis orientalis cosmid pCZA382. XX KW ABC transporter; acetyltransferase; alcohol dehydrogenase; KW aminotransferase; carboxylic acid dehydrogenase; KW integral membrane sugar transporter; ion antiporter; KW large multi-functional; mannitol dehydrogenase; oxidoreductase; KW peptide synthetase; phosphoenolpyruvate phosphomutase; KW phosphonopyruvate decarboxylase; phosphopantetheine attachment site; KW rRNA methylase; transcriptional regulator; transferase; transposase; KW vancomycin biosynthesis; WD-repeat containing. XX OS Amycolatopsis orientalis OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Pseudonocardineae; Pseudonocardiaceae; Amycolatopsis. XX RN [1] RP 1-42369 RA Lennard N., Harris B.; RT ; RL Unpublished. XX RN [2] RP 1-42369 RA Bentley S.D., Parkhill J., Barrell B.G., Rajandream M.A.; RT ; RL Submitted (27-MAY-1999) to the EMBL/GenBank/DDBJ databases. RL Pathogen Group, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, RL Cambridge CB10 1SA E-mail: barrell@sanger.ac.uk XX RN [3] RP 1-42369 RA van Wageningen A., Kirkpatrick P., Williams D., Harris B., Kershaw J., RA Lennard N., Jones M., Jones S., Solenberg P.; RT "Sequencing and analysis of genes involved in the biosynthesis of a RT vancomycin group antibiotic"; RL Unpublished. XX FH Key Location/Qualifiers FH FT source 1..42369 FT /organism="Amycolatopsis orientalis" FT /strain="A3(2)" FT /mol_type="genomic DNA" FT /clone="cosmid pCZA382" FT /db_xref="taxon:31958" FT CDS <1..316 FT /codon_start=2 FT /transl_table=11 FT /gene="CZA382.01" FT /product="putative phosphoenolpyruvate phosphomutase" FT /label=CZA382.01 FT /note="CZA382.01, partial CDS, possible phosphoenolpyruvate FT phosphomutase, len: >104aa; similar to the N-terminal FT region of TR:O86937 (EMBL:Y14337) phosphoenolpyruvate FT phosphomutase from Streptomyces viridochromogenes Tu494 FT (313 aa) fasta scores; opt: 252, z-score: 341.9, E(): FT 1e-11, (37.0% identity in 92 aa overlap)" FT /db_xref="GOA:Q9XBF0" FT /db_xref="HSSP:1PYM" FT /db_xref="InterPro:IPR015813" FT /db_xref="UniProtKB/TrEMBL:Q9XBF0" FT /protein_id="CAB45022.1" FT /translation="ILVHSKKSSPREVIEFLDAWQGRAPVVVVPTTYHDWHFTDAENAG FT VSLVIYANHALRAAVRSMSQVLSSIESSGASTSVEDLIAPVSEVFELTQLDKWLHLEKQ FT " FT CDS 313..1428 FT /transl_table=11 FT /gene="CZA382.02" FT /product="putative phosphonopyruvate decarboxylase" FT /label=CZA382.02 FT /note="CZA382.02, probable phosphonopyruvate decarboxylase FT len: 371aa; similar to TR:O86938 (EMBL:Y14337) FT phosphonopyruvate decarboxylase from Streptomyces FT viridochromogenes Tu494 (397 aa) fasta scores; opt: 502, FT z-score: 566.4, E(): 3.2e-24, (40.2% identity in 391 aa FT overlap). Contains Prosite match to PS00187 Thiamine FT pyrophosphate enzymes signature and Pfam match to entry FT PF00205 TPP_enzymes." FT /db_xref="GOA:Q9XBE9" FT /db_xref="InterPro:IPR000399" FT /db_xref="UniProtKB/TrEMBL:Q9XBE9" FT /protein_id="CAB45023.1" FT /translation="MIGADEFAAALLDQDYQFFSGVPCSRLAGVTSILSSHEGRYVPAA FT NEGAALAIAAGARMAGTRAAVLIQNSGLGNMVNPLTSLVLPYEIPVLVVVSLRGWPVGT FT DEPQHNVMGKATKPMADLCGMPSMVLEPSLGSLAEALASSQKAEMDGKPFCLLVPKGTV FT KSADPAPTPSSGVLSRVDAVRIVSAQARDAAIYSTTGYTSRELFAAADRPGNFYMQGSM FT GHALALGLGSALRRPDRRVVVLDGDGAALMHMGTMSTVGNLAPANLLHVVLDNGTYGST FT GSQPTTSATVDWPALARANGYRDAWLCADGAELQGVLGKALTQPGPCLVAVRIRASETD FT VPPRASAELPLPGIRNRFEHELAVGPGGQMT" FT misc_feature 970..1308 FT /note="Pfam match to entry PF00205 TPP_enzymes, , score FT 28.90, E-value 2.5e-08." FT misc_feature 1000..1059 FT /note="PS00187 Thiamine pyrophosphate enzymes signature." FT CDS 1425..2558 FT /transl_table=11 FT /gene="CZA382.03" FT /product="putative alcohol dehydrogenase" FT /label=CZA382.03 FT /note="CZA382.03, probable iron-containing alcohol FT dehydrogenase, len: 377aa; similar to many eg. FT SW:ADH1_CLOAB NADPH-dependent butanol dehydrogenase from FT Clostridium acetobutylicum (388 aa) fasta scores; opt: 411, FT z-score: 485.6, E(): 1e-19, (27.4% identity in 361 aa FT overlap). Also contains a region similar to TR:P96075 FT (EMBL:AB016934) FomC a protein which lies downstream of a FT phosphoenolpyruvate phosphomutase and phosphonopyruvate FT decarboxylase in the Streptomyces wedmorensis fosfomycin FT biosynthetic cluster (262 aa) fasta scores; opt: 462, FT z-score: 547.9, E(): 3.4e-23, (41.0% identity in 227 aa FT overlap). Contains 2 Pfam matches to entry PF00465 Fe-ADH." FT /db_xref="GOA:Q9XBE8" FT /db_xref="InterPro:IPR001670" FT /db_xref="UniProtKB/TrEMBL:Q9XBE8" FT /protein_id="CAB45024.1" FT /translation="MTDVDDQRRVEVIEGAGVAAKLPAVLRKMRAQRVLVVATRNAVHR FT TGAPGWLARHAHDYFYDVAPNPQAADVVRGARAVLRYKPDVVIGVGGGSTLDTAKAVRL FT LPPTKDEAERVLRGDEPIRVARPPRLVVIPTTAGPGSEVTAFATIYVGTRKYSLDHPTV FT KADVALIDPALTHSCPPTLTAHCALDATAHAIESWWSLRSSAPSRDLARSALARLVPIL FT QKGFRDTSSQQRELLSNAAVMAGQAIDLTRTTAAHAFAYPTTARFGVPHGLACALHLVW FT LLPLTLSQLEPSSSRMAADDIGHMLRLLGARTTAESGAAFARLLRLAGCPTRLGEVGVR FT ASDLELMFDDALSNSRAQNHPIALRKDSVLESMRSRL" FT misc_feature 1611..2015 FT /note="Pfam match to entry PF00465 Fe-ADH, , score 73.40, FT E-value 4.2e-20." FT misc_feature 2193..2531 FT /note="Pfam match to entry PF00465 Fe-ADH, , score 7.50, FT E-value 0.31." FT CDS 2578..3666 FT /transl_table=11 FT /gene="CZA382.04" FT /product="putative aminotransferase" FT /label=CZA382.04 FT /note="CZA382.04, probable aminotransferase, len: 362aa; FT similar to many belonging to class-V of FT pyridoxal-phosphate-dependent aminotransferases egs. FT SW:DHSS_SYNP1 soluble hydrogenase from Anabaena cylindrica FT (384 aa) fasta scores; opt: 839, z-score: 978.3, E(): 0, FT (38.7% identity in 359 aa overlap) and SW:SGAA_HYPME FT serine-glyoxylate aminotransferase from Hyphomicrobium FT methylovorum GM2 (404 aa) fasta scores; opt: 628, z-score: FT 733.2, E(): 0, (32.6% identity in 365 aa overlap). Contains FT Pfam match to entry PF00266 aminotran_5." FT /db_xref="GOA:Q9XBE7" FT /db_xref="HSSP:1H0C" FT /db_xref="InterPro:IPR000192" FT /db_xref="UniProtKB/TrEMBL:Q9XBE7" FT /protein_id="CAB45025.1" FT /translation="MNLRISGPTPLPPRVRAALSTDMISHRSTAFRDIVAEVLAGLTPV FT FGDPATILPFTCSGTGGLEAAVVNTVRPGQRVVVVSIGYFGTRMAEIARMAGLDIEVIE FT VPWGQAADPGELQAVLRRLRDVAAVLVTHNETSTGVLNPLPELCRVVRESSDALLIVDV FT VSSVGATPVRMRDWGIDVAVGVSQKALMSPPGLALLGVSSRALTAAAANPARRYYFDFT FT AMARAVEENTTTYTPAIPVFHALQTALRMISVEGWDRVLARHQRLSEQCRSGLADLGLA FT FAADQPYASPTVTSFFVPADMRASDVRERMAVEHKVQVASGRAKWKDSVLRIGHMGYVN FT ENDVAHVLAALGAVLDRAGGSS" FT misc_feature 2590..3618 FT /note="Pfam match to entry PF00266 aminotran_5, , score FT 73.60, E-value 4.3e-18." FT misc_feature 3663..4841 FT /note="Pfam match to entry PF00155 aminotran_1, , score FT 111.10, E-value 2.2e-29." FT CDS 3663..4847 FT /transl_table=11 FT /gene="CZA382.05" FT /product="putative aminotransferase" FT /label=CZA382.05 FT /note="CZA382.05, probable aminotransferase, len: 394aa; FT similar to many belonging to class-I of FT pyridoxal-phophate-dependent aminotransferases eg. FT SW:AAT_BACST aspartate transaminase from Bacillus FT stearothermophilus production of the herbicide FT phosphinothricin (393 aa) fasta scores; opt: 600, z-score: FT 681.6, E(): 1.2e-30, (31.4% identity in 392 aa overlap). FT Contains Prosite match to PS00105 Aminotransferases class-I FT pyridoxal-phosphate attachment site and Pfam match to entry FT PF00155 aminotran_1." FT /db_xref="GOA:Q9XBE6" FT /db_xref="HSSP:1DJU" FT /db_xref="InterPro:IPR004839" FT /db_xref="UniProtKB/TrEMBL:Q9XBE6" FT /protein_id="CAB45026.1" FT /translation="MNRVLSALAPHSSKRISEYAQRHPGTVDLTVGLPAFGPPRSFDER FT LAMLSSAPHVNARPEDQYAHSRGAIELRAAIAHVYKSEQGVDLDPDTQILVTNGAAGAL FT WIAVLTLTEPGDEVLLADPGYMIYPPMIELLGRRVVRIPTSPADGFRLHLSDLRSRLTQ FT RSRVVLVNSPGNPTGRVSSEDELADLCAFAVEHGLYVVHDEVLDRFAYGIEHRSVVALD FT HQGVGIAVNGLSKRFGMSGWRIGWLASSSAVIAEAAKAHTFFMLAVSHAVQLAAAAALS FT DPKADGEVSVYAAEIRRRGEVFLADLARIPGLGKTTVPDGGFYAFVDVGEFARLRGIRV FT AESTSAAVAEYLLHECGVAVVPGSVFGRAGEGFVRMSFAGSAEQLDRAVKRLAG" FT misc_feature 4356..4397 FT /note="PS00105 Aminotransferases class-I FT pyridoxal-phosphate attachment site." FT CDS 4849..5589 FT /transl_table=11 FT /gene="CZA382.06" FT /product="putative transferase" FT /label=CZA382.06 FT /note="CZA382.06, probable transferase, len: 246aa; some FT similarity to many proposed sugar-phosphate transferases FT eg. TR:O29123 (EMBL:AE001025) glucose-1-phosphate FT cytidyltransferase from Archaeoglobus fulgidus and FT TRNEW:AAC69536 (EMBL:AF057294) from the capsular FT polysaccharide locus of streptococcus pneumoniae (234 aa) FT fasta scores; opt: 335, z-score: 413.1, E(): 1.1e-15, FT (27.2% identity in 235 aa overlap). Contains Pfam match to FT entry PF00483 NTP_transferase." FT /db_xref="GOA:Q9XBE5" FT /db_xref="InterPro:IPR005835" FT /db_xref="UniProtKB/TrEMBL:Q9XBE5" FT /protein_id="CAB45027.1" FT /translation="MDREVRVIIPAAGVGSRLRPYTEDAPKALVPIAGKPLIWHTMRRL FT AKMKVSEVVVVSGYMSEMLRASLEACPDTPPLRFVENPDFASTNSIVSLGLTKPFWDTP FT FCVIDGDVLVSCDLLQRVLDSPRDVLAVDTSKVYADIDMKVRIHDGRAVDFGKDLSPSA FT RQGEFFGVSRWSPANAARLASAIDELLAAGKVGEWYESAMRRLAVEGGLDVLDATTDEW FT AEVDSAADIPTATALVERDEASFA" FT misc_feature 4864..5571 FT /note="Pfam match to entry PF00483 NTP_transferase, , score FT -39.60, E-value 0.0001." FT CDS 5590..6045 FT /transl_table=11 FT /gene="CZA382.07" FT /product="putative acetyltransferase" FT /label=CZA382.07 FT /note="CZA382.07, probable acetyltransferase, len: 151aa; FT similar to many eg. SW:AAC6_ENTAE aminoglycoside FT N6'-acetyltransferase from Enterobacter aerogenes (152 aa) FT fasta scores; opt: 145, z-score: 188.8, E(): 0.0035, (25.2% FT identity in 143 aa overlap). Contains Pfam match to entry FT PF00583 Acetyltransf." FT /db_xref="GOA:Q9XBE4" FT /db_xref="InterPro:IPR016181" FT /db_xref="UniProtKB/TrEMBL:Q9XBE4" FT /protein_id="CAB45028.1" FT /translation="MRTVRGVPTIRAATAEDLPAILGLYAELHPDDPVPSPESVQRAWA FT AIQAQPGRTILVSEVDSVVVGTTDCAIQANLTRNTRSLMLIENFVVAAASRRTGVGSAL FT LREAVRLAREAGCYKVQLLSRSSRTDAHAFYESQGFKTLAEGYRLYL" FT misc_feature 5617..6012 FT /note="Pfam match to entry PF00583 Acetyltransf, , score FT 65.00, E-value 1.6e-15." FT CDS 6581..6964 FT /transl_table=11 FT /gene="CZA382.08" FT /product="hypothetical protein" FT /label=CZA382.08 FT /note="CZA382.08, unknown, len: 131aa; prediction based on FT amino acid usage." FT /db_xref="UniProtKB/TrEMBL:Q9XBE3" FT /protein_id="CAB45029.1" FT /translation="MGPDAQRPELVEGERAIRETLDHLLDPVELGVPVRVGGFLPGLGA FT LEGDAAASEQTPQRLTADLDQPAGGGAQVGGEFADRPAREGAGRVSPGGWWPSPRRDRP FT GQDRVGGDGLPPTEGPDRPDRSH" FT CDS 7427..7855 FT /transl_table=11 FT /gene="CZA382.09" FT /product="putative transposase (fragment)" FT /label=CZA382.09 FT /note="CZA382.09, probable transposase (fragment), len: FT 142aa; similar to many eg. TR:Q50761 (EMBL:X65618) FT tranposase from Mycobacterium tuberculosis (308 aa) fasta FT scores; opt: 291, z-score: 368.1, E(): 3.5e-13, (35.0% FT identity in 143 aa overlap) and TR:O69927 (EMBL:AL023861) FT putative IS1648 transposase from Streptomyces coelicolor FT (141 aa) fasta scores; opt: 422, z-score: 534.9, E(): FT 1.8e-22, (51.9% identity in 133 aa overlap). CDS probably FT expressed by frameshifting into downstream ORF." FT /db_xref="UniProtKB/TrEMBL:Q9XBE2" FT /protein_id="CAB45030.1" FT /translation="MARRFDLTDVQWALLEPLLPQPSRSGRPSLWSKRQLIDGIRWRVR FT TGAPWRDMPTMYGSWAAAYGLFRRWQRTGAWQRMLITLQALADAAGHITWDVSVDSTIA FT RAHQHAAGARKRGICRPNRRAGSPPSRRITRWAGRGVD" FT CDS 7856..8302 FT /partial FT /transl_table=11 FT /gene="CZA382.10" FT /product="putative transposase (fragment)" FT /label=CZA382.10 FT /note="CZA382.10, probable transposase (fragment), len: FT 148aa; similar to many eg. TR:Q50761 (EMBL:X65618) FT tranposase from Mycobacterium tuberculosis (308 aa) fasta FT scores; opt: 294, z-score: 364.0, E(): 6e-13, (51.6% FT identity in 91 aa overlap) and TR:O69927 (EMBL:AL023861) FT putative IS1648 transposase from Streptomyces coelicolor FT (141 aa) fasta scores; opt: 379, z-score: 471.3, E(): FT 6.4e-19, (56.0% identity in 109 aa overlap). CDS probably FT expressed by frameshifting from upstream ORF." FT /db_xref="GOA:Q9XBE1" FT /db_xref="InterPro:IPR002559" FT /db_xref="UniProtKB/TrEMBL:Q9XBE1" FT /protein_id="CAB45031.1" FT /translation="PRTASGLRARPEAVVDRADRWPARRQSAVHPCPGGYPGARLIGGR FT ARTRPDRVLADKAYTAKANREHLRRRGIRATIPSKTDQDAHRTAKGSKGGRPPVFDPEI FT YKQRHAVECGINRLKRHRAVATRYDKLAVRYEATVHIAVINEWL" FT CDS 8493..11456 FT /transl_table=11 FT /gene="CZA382.11" FT /product="putative large multi-functional protein" FT /label=CZA382.11 FT /note="CZA382.11, possible large multi-functional protein, FT len: 987aa; contains 3 regions with weak similarity to FT different groups of proteins eg. 660-815aa similar to FT SW:CTA1_BACCI cycloisomaltooligosaccharide FT glucanotransferase (972 aa) fasta scores; opt: 287, FT z-score: 307.4, E(): 8.6e-10, (35.9% identity in 156 aa FT overlap), 225-490aa similar to SW:SNDH_ACELI L-sorbosone FT dehydrogenase (449 aa) fasta scores; opt: 156, z-score: FT 170.1, E(): 0.038, (22.2% identity in 302 aa overlap) and FT 120-230aa similar to SW:GSPB_ERWCH general secretion FT pathway protein B from Erwinia chrysanthemi (220 aa) fasta FT scores; opt: 116, z-score: 131.3, E(): 5.6, (26.4% identity FT in 125 aa overlap). Contains hydrophobic N-terminus." FT /db_xref="GOA:Q9XBE0" FT /db_xref="InterPro:IPR011658" FT /db_xref="UniProtKB/TrEMBL:Q9XBE0" FT /protein_id="CAB45032.1" FT /translation="MPPVAALLAAVIAVPLLPVPASAQPAIPPQEPGVTMRVFDVQVPL FT NDYCKLKPGQTPNVDKLMPAIDWSSNADFGIADRFVTEVSAYLHVSTAGTYDFRLTSDD FT GARFLLDGTQVIDHPGRHGATAKDGSAQLAAGHHALRIDHFDADFDQRLKLEWRPPGAA FT EYTVVPNSALSTDADVVRVTSPGRKQCEGVTDAPGDGLPLTDVHPAYTLTNLRPNGFEP FT QVTGMDWLPDGRLAISTWGGDRLTVLGEVFLLDGVTGNTDPSKVSIKRIAHGLREPMGL FT KYVDGTVYVSEKHQLTALVDKTGDEVADEYRRIATWPFGGNYHEFAFGLLYKDGYFYVT FT TGIAMVPGGATADPQPVPNRGSTLKIDKNTGDVSYVAGGLRTPNGLGWGPEGDAFVTDN FT QGMWVPASKLVRIKHRAFYNHYTNPGGPFDDQPVTEPVLWLPHNEISNSPSNPIVLPDG FT VFKDQMVFGDVTYGGLQRAYLEKVGGEYQGAVFRMTQGLESGVSRISVGPDGAIYTGGI FT GWAGNWGQEGKLKYGLQKLSLNGANAFDIHSMRAIKGGFELEYTQPLSDETAKDLAAKY FT KAQQWRYVATPQYGGPKVDEETLGVTSATLSTDRKKVTLQIAGLKPGRVVYLRSPRPFN FT SASGAELWSTEAWYTLNRLPDGTVAPQEYEAESARLTGGTGWNTNHAGYSGAGFVDRNW FT EPGSTTTFAVRPARAGRHNIALRYANGPNPSPNPVSKSMSLYVNGKKEKQIWLAATGSW FT SKWATHVETVTLRPGANTISYVYEPTDTGHVNLDKITLSMTNRVTLFNGTNLDAWETTS FT GAPATWPVADGSMESFGGDIRTKERFGDFRMHVEWYEPDYPPEVTGQARGNSGVYIYES FT YELQVLESHGRPPELNGAGAIYLKKAPDVNAATPTGTWQTYDIEFRAARFDAAGKKVEN FT ARITVWWNGKLVHNNVAIDGPTGAGKPEDPAPGHIKLQDHGDPGANPRFRNIWIERR" FT CDS 11494..11940 FT /transl_table=11 FT /gene="CZA382.12" FT /product="hypothetical protein" FT /label=CZA382.12 FT /note="CZA382.12, unknown, len: 148aa; predicted based on FT amino acid usage." FT /db_xref="UniProtKB/TrEMBL:Q9XBD9" FT /protein_id="CAB45033.1" FT /translation="MLVRRSENVDLAVRRAADHGAANLVVVLDLEPHVARDPAVRADVV FT PGDVLHLKSVGVEPVAAQVGVTLARGQPVLATGERTRVPGRATVTATRAELRDLHRPCG FT RQAVVDVAPGAGIGVRGLSVHEREPDRSGDRHYERSDASNRFEF" FT CDS 12295..16020 FT /transl_table=11 FT /gene="CZA382.13" FT /product="putative WD-repeat containing protein" FT /label=CZA382.13 FT /note="CZA382.13, possible WD-repeat containing FT ATP/GTP-binding protein, len: 1241aa; similar to many FT eukaryotic WD-repeat proteins over the extent of the repeat FT region eg. TR:O93531 (EMBL:AF069737) Notchless regulatory FT protein from Xenopus laevis (African clawed frog) (476 aa) FT fasta scores; opt: 586, z-score: 640.9, E(): 2.3e-28, FT (31.9% identity in 383 aa overlap). Also more extensive FT similarity to proteins from prokaryotes eg. TR:AAD21044 FT (EMBL:AF116463) putative regulatory WDLA from Streptomyces FT lincolnensis (971 aa) fasta scores; opt: 1486, z-score: FT 1619.5, E(): 0, (41.7% identity in 917 aa overlap) and FT TR:CAA10512 (EMBL:AJ131817) WD-40 repeat protein from FT Streptomyces coelicolor (1049 aa) fasta scores; opt: 907, FT z-score: 986.4, E(): 0, (41.7% identity in 1060 aa FT overlap). Contains 13 Pfam matches to entry PF00400 WD40 FT and 12 Prosite matches to PS00678 Trp-Asp (WD) repeats FT signature. Also contains Prosite match to PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /db_xref="HSSP:1ERJ" FT /db_xref="InterPro:IPR020472" FT /db_xref="UniProtKB/TrEMBL:Q9XBD8" FT /protein_id="CAB45034.1" FT /translation="MGRRERPLDPDAGSLQRFAFELRQLRSVAGQPGYRELSRRAHYSI FT TALAEAAGGQTLPSLAVTLAYVQACGGDRQVWETRWRELAEELALANGDSADPDASPYL FT GLAAFQPDDADRYFGRDSLVEHVVHKVAQTPVVAVFGASGSGKSSLIRAGLIPATRTHS FT AFSGNQWTCVLLTPTSQPLRELAHAVTELCGTEPDRSEPGWLGRALHHAHHPRVLLVVD FT QFEELFTLCPNPDERVEFIDALLDAARSPDGMVHVVLGVRADFYGHCATHPGLLKTLGE FT GAQVLVGPMTKDELRSAITGPAAMAGLTVERELVATMIADIADEPGGLPLLSHALLETW FT RHRRNSTMTKAGYHVCGGVHGALAQTAERLYAEFDAAEQEVAHRIFLRLTALGDGTEDT FT RRRARHGELATVGDSSTVTRVLDKLAAARLVVIGTDSVEVAHEALIRAWPRLRRWLTDD FT REGVLLHRRITDATQLWQSSGRDPGLLYQATQLDQAIAWADQTHRASALNADEREFLDA FT ATLLRDKQIRSRKQRTLRLRVATAAVVAVLAAASVITWQQRNEARDQHRVAVARQLVAE FT ATALREIDPLRAAQLSLIAWQIAPDVPATRDSLLSVQAYPLPTRLLGHTGEVRDVAFSP FT DGRVLATAAGDSSVRLWDIASRQPLGNPLTGHTGMVNGLAFSPDGTTLATASADRTVRL FT WDVARHRPIGEPMSGHTNTVTSIAFSSDGRLLVTGSADGTVRTWDITSRTPIGEPMVGH FT KGPITAVALSPDGVTAATSSNDKTVRLWNVATRAPIGDPLTGHTSVTNGVAFSPDGQIL FT ASTSGDKTVRLWNVATRAPIGDPLTGHTNVTYGVAFSPDGRTLATSSWDKTVRIWDTTS FT RRQQGTALIGSTSSVFNIAFSPDGSALAGGDSDSSTLVWSLRGTLVPAHADAVYAVALS FT PEGRVLGTGADDRKVRLWETSTHRELVAPLTGHTAEVRSMAFSPQGGILATGSWDGTLR FT LWDAANRAPIGSPLTGHVDWVRGLAFSPDGHFVATAGMDMTVRLWNVATRAPFGPPLTG FT HTNSVTGIAFSPDGRSLATAANDKTIRLWDVPSRSPIGEPLTGHTSVVRDVVFSPDGKL FT LASAGDDKTVRLWDVASRTLIATLEGHTGEVLKLAISPDGRELASTSLDKTVRLWDTAN FT RSTTTVLSASTGLAGVAYTPDGLVTGGVTGNVLLWTTDVTRLAGQVCAATGSELSDDEW FT RRYLPTWPRMKVCAGT" FT misc_feature 12715..12738 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT misc_feature 14137..14253 FT /note="Pfam match to entry PF00400 WD40, , score 42.20, FT E-value 1.2e-08." FT misc_feature 14212..14256 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT repeat_region 14220..15732 FT /note="Large degenerate repeat region of 13 x approx. 116 FT bases." FT misc_feature 14263..14382 FT /note="Pfam match to entry PF00400 WD40, , score 41.00, FT E-value 2.7e-08." FT misc_feature 14341..14385 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 14395..14511 FT /note="Pfam match to entry PF00400 WD40, , score 43.00, FT E-value 6.5e-09." FT misc_feature 14470..14514 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 14524..14640 FT /note="Pfam match to entry PF00400 WD40, , score 29.80, FT E-value 6.3e-05." FT misc_feature 14599..14643 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 14653..14769 FT /note="Pfam match to entry PF00400 WD40, , score 33.10, FT E-value 6.6e-06." FT misc_feature 14728..14772 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 14782..14898 FT /note="Pfam match to entry PF00400 WD40, , score 41.50, FT E-value 1.9e-08." FT misc_feature 14857..14901 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 14911..15027 FT /note="Pfam match to entry PF00400 WD40, , score 12.50, FT E-value 1.1." FT misc_feature 15031..15141 FT /note="Pfam match to entry PF00400 WD40, , score 17.10, FT E-value 0.32." FT misc_feature 15100..15144 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 15154..15270 FT /note="Pfam match to entry PF00400 WD40, , score 50.70, FT E-value 3.3e-11." FT misc_feature 15229..15273 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 15283..15399 FT /note="Pfam match to entry PF00400 WD40, , score 42.80, FT E-value 7.6e-09." FT misc_feature 15358..15402 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 15412..15528 FT /note="Pfam match to entry PF00400 WD40, , score 42.20, FT E-value 1.2e-08." FT misc_feature 15487..15531 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 15541..15657 FT /note="Pfam match to entry PF00400 WD40, , score 44.80, FT E-value 1.9e-09." FT misc_feature 15616..15660 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT misc_feature 15667..15783 FT /note="Pfam match to entry PF00400 WD40, , score 42.00, FT E-value 1.3e-08." FT misc_feature 15742..15786 FT /note="PS00678 Trp-Asp (WD) repeats signature." FT CDS complement(16027..16635) FT /transl_table=11 FT /gene="CZA382.14c" FT /product="hypothetical protein" FT /label=CZA382.14c FT /note="CZA382.14c, unknown, len: 202aa; similar to FT TR:Q51078 (EMBL:Z21683) DNA-binding protein from FT Streptomyces lactamdurans (214 aa) fasta scores; opt: 408, FT z-score: 488.2, E(): 7.3e-20, (39.7% identity in 209 aa FT overlap)" FT /db_xref="GOA:Q9XBD7" FT /db_xref="InterPro:IPR002734" FT /db_xref="UniProtKB/TrEMBL:Q9XBD7" FT /protein_id="CAB45035.1" FT /translation="MATVNCNITISADGYSAGHNQTEQRPFGDDGGDGTGDKLHAWMFD FT SPEENQAEIDQMTAATAFIMGRNMFGPVRGEWDRPWNGWWGDNPPFHGPVFVLTHHERD FT PQPMDGGTTYHFVTDGIESALEQARAAAGDGEVTILGGATTINQYLAAGLIDEVRLHIV FT PFTLGAGTRLFEGVPPLKLEQVKSRATTSVTHVTYRVLS" FT CDS 16750..17091 FT /transl_table=11 FT /gene="CZA382.15" FT /product="hypothetical protein" FT /label=CZA382.15 FT /note="CZA382.15, unknown, len: 113aa;" FT /db_xref="UniProtKB/TrEMBL:Q9XBD6" FT /protein_id="CAB45036.1" FT /translation="MSETDPHIHVEQKVLEAGPTVRNMISSMLGRVTDAPSVVTTGCGI FT QVPYAMTSHRPESVTCLACRDHAHREYLRFADQFERLGQGAMSGLNITEDQVAEAVERL FT RDLAKRFSS" FT CDS complement(17254..18573) FT /transl_table=11 FT /gene="CZA382.16c" FT /product="putative mannitol dehydrogenase" FT /label=CZA382.16c FT /note="CZA382.16c, probable mannitol dehydrogenase, len: FT 439aa; similar to many egs. SW:UXUB_ECOLI D-mannonate FT oxidoreductase from Escherichia coli (486 aa) fasta scores; FT opt: 931, z-score: 1083.7, E(): 0, (37.6% identity in 455 FT aa overlap) and TR:O08355 (EMBL:AF007800) mannitol FT dehydrogenase from Pseudomonas fluorescens DSM 50106 (493 FT aa) fasta scores; opt: 796, z-score: 926.8, E(): 0, (36.2% FT identity in 406 aa overlap). Contains Pfam match to entry FT PF01232 Mannitol_dh." FT /db_xref="GOA:Q9XBD5" FT /db_xref="HSSP:1LJ8" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9XBD5" FT /protein_id="CAB45037.1" FT /translation="MVPRLSRSTYPAASPRAGIGIVHLGLGAFHRAHQAVFTQEAMLAE FT PGDWAICAVGQRNPAVRDAMSTQDCLFTVTERDAEHEDLRVVDSVRDVLLASEQPDQVT FT AALADPATRIVTITVTEAGYRHDPATGRLRADDPEVAADVAGRPPRTVIGQLIRGLKAR FT EHSGLTVVPCDNLPDNGRLVAGLLRDFCVLSGQPELAERIAEQVRCPSTVVDQIVPATT FT DADIANVASLLGLLDRAAVVGETYRQWVIEDDFAAGRPAWDKAGVRLVADITPHQAAKL FT RLVNGTHSALTYLGLLAGCTSTAEVATRPEFARYAERLIREETGASLARFGIPVDIDGL FT LKRLANPRITHRLAQIAADGVRKLPQRLLDPAAELLESGAEPRMICLALAGFLRHERET FT PDCLFAARPALRDSRVFGELLTDAMHQLDRNGVLTTLRGI" FT misc_feature complement(17296..18519) FT /note="Pfam match to entry PF01232 Mannitol_dh, , score FT 258.50, E-value 8.7e-74." FT CDS complement(18580..19914) FT /transl_table=11 FT /gene="CZA382.17c" FT /product="putative integral membrane sugar transporter" FT /label=CZA382.17c FT /note="CZA382.17c, probable integral membrane sugar FT transporter, len: 444aa; similar to many transporters egs. FT TR:Q45082 (EMBL:U29532) MopB phthalate-specific permease FT from Burkholderia (Pseudomonas) cepacia (449 aa) fasta FT scores; opt: 1117, z-score: 1290.0, E(): 0, (39.8% identity FT in 450 aa overlap) and SW:SHIA_ECOLI shikimate transporter FT from Escherichia coli (438 aa) fasta scores; opt: 1030, FT z-score: 1190.0, E(): 0, (38.4% identity in 419 aa FT overlap). Contains Pfam match to entry PF00083 sugar_tr. FT Also contains several possible membrane spanning FT hydrophobic regions." FT /db_xref="GOA:Q9XBD4" FT /db_xref="InterPro:IPR011701" FT /db_xref="UniProtKB/TrEMBL:Q9XBD4" FT /protein_id="CAB45038.1" FT /translation="MTMTRAVNEDGAGQDTTPTELRRVVGASVVGTALEWYDFFIYGFA FT VTLVFNELFFTTGDPAMGVIIGFATFGVGFAVRPIGGFLFGHLGDRIGRRSTLVLTTLV FT MGVSTGLIGLLPTYDSIGVAAPILLTVLRMCQGLGAGAEFGGASTLLAEHAPARRRGFF FT TSFAQTGVQIGLLSGVTVFLLIELLPRQTVLDWAWRIPFLFSFVLIAVALYVRLRVAES FT PVFQQMSERRTTVKMPVLDALRHYPRNFLIGIGAHICDTAVVYIYATYSLTYITKTLAM FT PRWVALTGVIIFSVIVIALQPVYGALSDRVGRRPLNLFSVVFTAAFAFPFFLLLDTREP FT VLIWIALVLATSLGFAPMIAVQPAFYAELFGARVRYTGFAASREIGAALGGFSPLIAAA FT LVAQAGGKGWLVALWMIATAAISFVAFWLSKESKDVDITVIDATR" FT misc_feature complement(18583..19848) FT /note="Pfam match to entry PF00083 sugar_tr, , score FT 107.10, E-value 3.4e-28." FT CDS complement(19911..20924) FT /transl_table=11 FT /gene="CZA382.18c" FT /product="putative carboxylic acid dehydrogenase" FT /label=CZA382.18c FT /note="CZA382.18c, probable carboxylic acid dehydrogenase, FT len: 337aa; similar to many eg. SW:LDH_ALCEU L-lactate FT dehydrogenase from Alcaligenes eutrophus (349 aa) fasta FT scores; opt: 605, z-score: 665.5, E(): 9.7e-30, (35.1% FT identity in 342 aa overlap)." FT /db_xref="GOA:Q9XBD3" FT /db_xref="InterPro:IPR003767" FT /db_xref="UniProtKB/TrEMBL:Q9XBD3" FT /protein_id="CAB45039.1" FT /translation="MNVQAAELEALATRILVAAGSSTVDAETVARSLVGSDLLGHDSHG FT VRRVIDYVKRIHTGLIDPRAEPKAETTRPGTVVVHGRRAFGQLAVRRAVRELLSLVPHQ FT GSGVAVVRECNHIGRLGEYVAMLADQDLIGLAFGNADPTVAPYGGRERRLGTNPLAWAV FT PRGPGQPPIVMDWATSGIAEGKLRVARDRGEQVAEGLVLDAAGRPSTTPADFYQGGALL FT PFGGHKGYGLSVLIEIVGGLLSGIGIGSMPGFREGWGTVLVAFDIAAFLPVPEFRAQTE FT RFCQALAETPLAEGASEVLVPGEPEERIRLERARDGIPVTANTWRELNALLRTEEE" FT CDS complement(21011..21757) FT /transl_table=11 FT /gene="CZA382.19c" FT /product="putative transcriptional regulator" FT /label=CZA382.19c FT /note="CZA382.19c, probable transcriptional regulator, len: FT 248aa; similar to many regulators of catabolism eg. IclR FT Regulator of the glyoxylate bypass operon from Escherichia FT coli (274 aa) fasta scores; opt: 411, z-score: 485.8, E(): FT 9.9e-20, (33.3% identity in 243 aa overlap). Note possible FT alternative start codon at residue 16." FT /db_xref="GOA:Q9XBD2" FT /db_xref="HSSP:1MKM" FT /db_xref="InterPro:IPR014757" FT /db_xref="UniProtKB/TrEMBL:Q9XBD2" FT /protein_id="CAB45040.1" FT /translation="MVGKSPQSAADKTLIVLEALADHARIADIAGAAGLPKPTVHRILQ FT TLVQHGFARSDGQGNYVCGPRILSLAGRFLQRLDIAEQVRPILRDLQERTGWTVHLALL FT SGDEAVYVAKVEGAKPYHLASRVGMSLKLHCTSIGKAILATMSDDQVAEIAARAGLPAR FT TQNTITDAPALLSELAAVRARRYAEDHEENEAGVRAVGAAVFDHTGGVIGGLSAAALVH FT LAPVVEDLPAQVTAAAEAVSKALGAH" FT CDS complement(21715..22611) FT /transl_table=11 FT /gene="CZA382.20c" FT /product="putative integral membrane transporter" FT /label=CZA382.20c FT /note="CZA382.20c, probable integral membrane transporter, FT len: 298aa; similar to SW:MER4_STRLI mercury resistance FT probable Hg transporter from Streptomyces lividans (319 aa) FT fasta scores; opt: 459, z-score: 514.6, E(): 2.5e-21, FT (34.9% identity in 281 aa overlap). Contains possible FT membrane spanning hydrophobic regions." FT /db_xref="GOA:Q9XBD1" FT /db_xref="InterPro:IPR003834" FT /db_xref="UniProtKB/TrEMBL:Q9XBD1" FT /protein_id="CAB45041.1" FT /translation="MDFDTLGFALAAGMIATVNPCGFAMLPAYLTLVVSGESRPTMNAV FT WRALAVTGLMALGFLAVFGAFGLVVAPLGSSVQEYLPAATVVIGVVMVGLGAWMLAGKQ FT ITLLVPKPRKGAPTARLSSMFGYGLAYAVVSLSCTIGPFLAVTSQTFRSGSVVTGIAAY FT LVYALGMALVVGVLAVSVALASTAVTTWVRRVLPYVNRIGGAILVLAGLYIGYYGVYEL FT RLFHAGGSADDPIVDGAGKVQALLSEWVDAVGPVPLVLGLVVLLGVGILVARLRAGRQL FT HWGTWLARVRSQRRTRR" FT CDS complement(22613..23188) FT /transl_table=11 FT /gene="CZA382.21c" FT /product="putative " FT /label=CZA382.21c FT /note="CZA382.21c, possible thioredoxin lipoprotein, len: FT 191aa; similar to SW:MP53_MYCTU soluble secreted antigen FT from Mycobacterium tuberculosis (173 aa) fasta scores; opt: FT 401, z-score: 445.7, E(): 1.7e-17, (43.4% identity in 145 FT aa overlap). Contains Pfam match to entry PF00085 thiored FT and Prosite match to PS00013 Prokaryotic membrane FT lipoprotein lipid attachment site. Also contains probable FT N-terminal signal sequence." FT /db_xref="GOA:Q9XBD0" FT /db_xref="HSSP:1LU4" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/TrEMBL:Q9XBD0" FT /protein_id="CAB45042.1" FT /translation="MLRRRIAGAVLAAILTSLAACGTDTSSTAPGTNSAAPPQTTSTGT FT STTSTQASPSVPDQLKFTVQTVDGQSFSGESLAGKKAVLWFWAPWCPKCRAEAPRVAAA FT AQATSGKVTFVGVAAQDALPAMKKFVTDYKVSGFTHLADLDAAIWTRFGVTQQPAYAFI FT SPDGKVDVVKQQLSESALTERVNALTAA" FT misc_feature complement(22844..22933) FT /note="Pfam match to entry PF00085 thiored, , score 18.20, FT E-value 0.00038." FT misc_feature complement(23126..23158) FT /note="PS00013 Prokaryotic membrane lipoprotein lipid FT attachment site." FT CDS complement(23637..24416) FT /transl_table=11 FT /gene="CZA382.22c" FT /product="putative rRNA methylase" FT /label=CZA382.22c FT /note="CZA382.22c, possible rRNA methylase, len: 259aa; FT similar to proteins of undefined function many of which FT have possible methylase function eg. SW:BIOC_SERMA biotin FT synthesis protein from Serratia marcescens (255 aa) fasta FT scores; opt: 209, z-score: 246.1, E(): 2.2e-06, (33.6% FT identity in 128 aa overlap). Contains Pfam match to entry FT PF00398 RrnaAD and Prosite match to PS01131 Ribosomal RNA FT adenine dimethylases signature." FT /db_xref="GOA:Q9XBC9" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q9XBC9" FT /protein_id="CAB45043.1" FT /translation="MEQDVRLLHASSFGAAAASYAEHRPDYAPAAARWALEHAPGPRVL FT DLGAGTGKLTAALVALGAEVIAVEPDPAMLTELRRAVPTVRALPGNAEAIPLPDASIDA FT VLAGNALHWFDMSVAGPEIARVLAPGGILAGLWNVMDNRVDWVAGLERVGGSAAIGSRD FT TFSSWRAATTGLHRPHTGVAARFGSPEQAEFPHGQRRTADSLVATLATRAGLLVMPEQE FT RRATLSRIRAFLASRPETNEGEFTLPMLTGVLRVRQL" FT misc_feature complement(24171..24287) FT /note="Pfam match to entry PF00398 RrnaAD, , score 19.70, FT E-value 2.5e-05." FT misc_feature complement(24204..24287) FT /note="PS01131 Ribosomal RNA adenine dimethylases FT signature." FT CDS complement(24443..25450) FT /transl_table=11 FT /gene="CZA382.23c" FT /product="putative transcriptional regulator" FT /label=CZA382.23c FT /note="CZA382.23c, possible transcriptional regulator, len: FT 335aa; similar to TR:CAB40927 (EMBL:AL049630) putative FT transcriptional regulator from Streptomyces coelicolor (368 FT aa) fasta scores; opt: 264, z-score: 311.0, E(): 5.4e-10, FT (31.4% identity in 274 aa overlap) and limited similarity FT to TR:O68020 (EMBL:AF010234) ArsR arsenic resistance FT transcriptional regulator from Pseudomonas aeruginosa (118 FT aa) fasta scores; opt: 113, z-score: 143.4, E(): 1.2, FT (33.9% identity in 56 aa overlap)." FT /db_xref="GOA:Q9XBC8" FT /db_xref="InterPro:IPR001845" FT /db_xref="UniProtKB/TrEMBL:Q9XBC8" FT /protein_id="CAB45044.1" FT /translation="MIELEFTAEDYRLIRFAMSPIGEAVKSLRVLSAGRKGGLHGRWLG FT WLAETDLTETVDLELLSALVRPQGYLPDFLGPLPSGGSTGIADGLAEIAATPLDVVRYE FT LDHLARHDIAQQGPGRERREALILQLADDPERALRTIVSQLERYWDVAIAPHWPRLNAL FT LHADLAHRLDELASGGVEKLFRSLHPSVAFRGDLLTIVKYFEGRLQLRGRGLLLVPCAF FT AWPDVLVSTADPMPSLTYPPRGLGTLWESGRTATAEPPLAAVIGGARATILALLDLPMS FT TTQLAAQLGSAPPTVNVHLKALAKAGIVTARRDGRMVLYRRTPLGDQLVAAAAE" FT repeat_region 25518..25760 FT /note="3x" FT CDS 25756..26817 FT /transl_table=11 FT /gene="CZA382.24" FT /product="hypothetical protein" FT /label=CZA382.24 FT /note="CZA382.24, unknown, len: 353aa;" FT /db_xref="UniProtKB/TrEMBL:Q9XBC7" FT /protein_id="CAB45045.1" FT /translation="MSALDDLLAAYERLHGAGPEFGGDEEGNHGLTNHGPMAVEVMVRR FT GLDIPVEKWLDGYVGRLDELPTASRRIDADDWRDALGDHRRIADWTAYFRAELHRAPWH FT DVLATWWPRLPPGIAAGSTHGVIRVGHAVRTLMITDHPHVHNELANGMAFWAARWRPIP FT TARGEGTLTPATALDALPRLPDQTGFIAHRISRLGTLPEWPGAVDSLRVPDDPDAVRAT FT LTQLIDAATLRYLAVGRDAPVLLVHTATAPNAVLHCLPVLPQQLWRPSLAAAWTATAAI FT TVMYAGHADHTTPTTVTGSDLAGNLLDRAATHRDEHVLKFADTATESYARTGDRATIAA FT AHLAADLIAAPAA" FT CDS 26814..27431 FT /transl_table=11 FT /gene="CZA382.25" FT /product="hypothetical protein" FT /label=CZA382.25 FT /note="CZA382.25, unknown, len: 205aa; similar to FT SW:YYAP_BACSU hypothetical protein from Bacillus subtilis FT (188 aa) fasta scores; opt: 205, z-score: 265.2, E(): FT 1.9e-07, (28.9% identity in 194 aa overlap)." FT /db_xref="GOA:Q9XBC6" FT /db_xref="InterPro:IPR002734" FT /db_xref="UniProtKB/TrEMBL:Q9XBC6" FT /protein_id="CAB45046.1" FT /translation="MTDTPTRHTNTRRETMRTLISTSFVSLDGKLDPTGGDPALHSTKW FT TFKTVDFLPEAYEIKGREQEEAGALLLGRASYELFAPVWPGMAEFARYKGLPKYVVSTT FT LTENDLVDDWGDNTILRSLDEVAELKQTEGDPILVHGSATLNRALHEAGLIDRYHLLVF FT PILLGAGKPLFSDADLPATRLKLVEHEVYPNGIQKQVFDVVR" FT unsure 27458..29690 FT /label=non-coding FT /note="Apparently non-coding region. CDSs could not be FT confidently predicted using the available prediction FT methods." FT CDS 29715..30680 FT /transl_table=11 FT /gene="CZA382.26" FT /product="putative transcriptional regulator" FT /label=CZA382.26 FT /note="CZA382.26, probable transcriptional regulator, len: FT 321aa; similar to other regulators of antibiotic FT biosynthesis eg. TR:Q54267 (EMBL:X78976) StrR FT transcriptional regulator of 5'-hydroxystreptomycin FT biosynthesis in Streptomyces glaucescens (424 aa) fasta FT scores; opt: 921, z-score: 1003.1, E(): 0, (47.9% identity FT in 307 aa overlap)." FT /db_xref="GOA:Q9XBC5" FT /db_xref="InterPro:IPR003115" FT /db_xref="UniProtKB/TrEMBL:Q9XBC5" FT /protein_id="CAB45047.1" FT /translation="MDPTRDDIVALPVVEIELSRLCSDSSPRTSGEDPEHVETLLSAEG FT NLPPILVHRPTMRVIDGLHRLKVARLRGDTKILARFVDGTESDAFVLAVESNIRHGLPL FT SLADRKRAAVQIIGTHPQWSDRRVASVTGISAGTVADLRRRGGESGNEARIGRDGRIRP FT VDGSEGRRLAAELIRGDPGLSLRQVAKQVGISPETVRDVRGRLERGESPTPDGSRRLQA FT KPQPLRWSGPDFGRVVDRDRLALLERLKADPALRLTEAGRTLLRMFAMHSIDGQEWGRV FT LHGVPPHLCSVVAGFARDHARVWAEFADHLENRASDLAAG" FT CDS 30677..31126 FT /transl_table=11 FT /gene="CZA382.27" FT /product="putative transcriptional regulator" FT /label=CZA382.27 FT /note="CZA382.27, probable transcriptional regulator, len: FT 149aa; limited similarity to many eg. TR:O69212 FT (EMBL:U33059) activator of rifamycin biosynthesis in FT Amycolatopsis mediterranei S699 (517 aa) fasta scores; opt: FT 237, z-score: 280.2, E(): 2.8e-08, (57.7% identity in 78 aa FT overlap). Contains Pfam match to entry PF00196 GerE and FT Prosite match to PS00622 Bacterial regulatory proteins, FT luxR family signature." FT /db_xref="GOA:Q9XBC4" FT /db_xref="HSSP:1FSE" FT /db_xref="InterPro:IPR000792" FT /db_xref="UniProtKB/TrEMBL:Q9XBC4" FT /protein_id="CAB45048.1" FT /translation="MIITSAGLRLGDMVVTESGTMRPRAVSAEIRGDAATMPEGRGPVK FT RPDGLTSQQREVWLPRQQNAGRDARDAAGPAHAPLTRAELRVAALAARGCVNREIAERL FT FITPSTVEQHLTRVFKKLGITGRDFLPTSLSAVSWQDSGAPRKDG" FT misc_feature 30905..31102 FT /note="Pfam match to entry PF00196 GerE, , score 34.60, FT E-value 2.3e-06." FT misc_feature 30956..31039 FT /note="PS00622 Bacterial regulatory proteins, luxR family FT signature." FT CDS 31432..32661 FT /transl_table=11 FT /gene="CZA382.28" FT /product="putative integral membrane ion antiporter" FT /label=CZA382.28 FT /note="CZA382.28, possible integral membrane ion FT antiporter, len: 409aa; similar to many eg. SW:NAPA_ENTHR FT Na(+)/H(+) antiporter from Enterococcus hirae (383 aa) FT fasta scores; opt: 406, z-score: 458.9, E(): 3.1e-18, FT (26.7% identity in 393 aa overlap) and TR:P72973 FT (EMBL:D90902) proposed Na(+)/H(+) antiporter from FT Synechocystis sp. PCC6803 (410 aa) fasta scores; opt: 679, FT z-score: 762.2, E(): 0, (41.8% identity in 409 aa overlap). FT Contains possible membrane spanning hydrophobic regions." FT /db_xref="GOA:Q9XBC3" FT /db_xref="InterPro:IPR006153" FT /db_xref="UniProtKB/TrEMBL:Q9XBC3" FT /protein_id="CAB45049.1" FT /translation="MSTHQVVFLLLDLAVIVVLARLLGAVARRLDQPPVIGELLAGILL FT GPTLFGEGFAAALFPTDVRPFLAALANVGVAMFMFMVGLELEQTLLRGRGKLALTVSVS FT SIVLPFTLGVGLAFYLAMNRPVEHRLGFLLFIGAAMSVTAFPVLARILQDRGMLRTMLG FT GLALTCAAIGDVLAWCLLAVVVIVSGGASGTEQWLIVLGPIYVALMLWVVRPLLRKLFT FT AGVTGALPTVLAGALISGAVTELIGLHFIFGAFLFGVIVPREGTDTLRHRIIDRVEEFN FT SALLLPVFFIVSGLKVNLSTLSATGLVEFGLVLLVAIAGKFGGAFVGARLHGLPARKSA FT ALATLMNTRGLTELIILTVGLQLGVLDQSLYSIMVAMAVITTAMAGPLLRLIYPASVIE FT RDQAIEQARL" FT misc_feature 32493..42369 FT /note="49385 (+1) 1 9877 AOPCZA363 AJ223999 Amycolatopsis FT orientalis cosmid PCZA363" FT CDS 32747..33850 FT /transl_table=11 FT /gene="CZA382.29" FT /product="putative oxidoreductase" FT /label=CZA382.29 FT /note="CZA382.29, probable oxidoreductase, len: 367aa; FT previously sequenced therefore identical to TR:O52817 FT (EMBL:AJ223999). Also similar to TR:CAB38592 FT (EMBL:AL035654) putative oxidoreductase from the calcium FT dependent antibiotic biosynthesis cluster of Streptomyces FT coelicolor (284 aa) fasta scores; opt: 757, z-score: 817.1, FT E(): 0, (49.8% identity in 283 aa overlap) and FT SW:TYRA_BACSU TyrA prephenate dehydrogenase from Bacillus FT subtilis (372 aa) fasta scores; opt: 362, z-score: 393.7, FT E(): 1.3e-14, (26.5% identity in 351 aa overlap)." FT /db_xref="GOA:O52817" FT /db_xref="InterPro:IPR003099" FT /db_xref="UniProtKB/TrEMBL:O52817" FT /protein_id="CAB45050.1" FT /translation="MEKVLVVGTGLIGTSAALALREKDVTVYLCDIDADAVRLARELGA FT GQEWTGQDVDLAVIAVPPHLVGESLADLQKQGAARAYTDVASVKVDPIADAERLGCDMT FT CYVPGHPLAGRERSGPAAARADLFLGRPWALCPGPETEAGAEQLARELVSLCGAKSVTV FT GARQHDSAVALVSHAPHVAASAVAASLESGDEVALGLAGQGLRDTTRIAAGDPLLWRMI FT LSGNAQPVAGVLDRIAADLVAAASALRSGDLDDVTDLLRRGVDGHGRIPGKHSGPVRDF FT ATVQVVLRDRPGELARLFNAAGLADVNVEDVRLEHSTGLPVGVAEISVRPQDTDRLADA FT LRFHGWHVPPVPATHQVSQHRSQGCPR" FT CDS 34054..36006 FT /transl_table=11 FT /gene="CZA382.30" FT /product="putative ABC transporter" FT /label=CZA382.30 FT /note="CZA382.30, probable ABC transporter, len: 650aa; FT previously sequenced therefore identical to TR:O52818 FT (EMBL:AJ223999). similar to many from prokaryotes and FT eukaryotes egs. SW:YWJA_BACSU hypothetical ABC transporter FT from Bacillus subtilis (575 aa) fasta scores; opt: 777, FT z-score: 844.1, E(): 0, (32.6% identity in 601 aa overlap) FT and TR:Q26598 (EMBL:L26286) ABC transporter from FT Schistosoma mansoni (blood fluke) (691 aa) fasta scores; FT opt: 747, z-score: 810.5, E(): 0, (30.1% identity in 634 aa FT overlap). Contains Pfam matches to entry PF00664 FT ABC_membrane and entry PF00005 ABC_tran and Prosite matches FT to PS00017 ATP/GTP-binding site motif A (P-loop) and FT PS00211 ABC transporters family signature." FT /db_xref="GOA:O52818" FT /db_xref="HSSP:1MV5" FT /db_xref="InterPro:IPR017940" FT /db_xref="UniProtKB/TrEMBL:O52818" FT /protein_id="CAB45051.1" FT /translation="MDMVLRFEGVDKSENDPDPWVTTVRKGTLRRVLGYFRPHVGKVAL FT FGLVAVLESLIVVATPLLLKELIDNGIEKNDLGLVIWMAALTAVLAVLAAGLTLVSGYI FT SGKIGEGITYDLRVQALDHVRRLPIAFFTRTQTGVLVGRLHTELIMAQQHFTGLLMATT FT SLVMALVVLIELFYLSWLVAVISLALIPLFLVPWVRVGRVIQRLSGRQMDANTGLGGLL FT QERFNVQGAMLSKLFGRPNEEMAEFEDRASGIRKIGVSLSVWGRMAFVMMALMASLATA FT LVYGVGGGLVLAGAFQVGTLVAIATLLGRLFGPITQLSGMQELFQTVVVSFSRVFELLD FT LKPLIQERPDAVKLDKDVAPDIEFENVSFRYPTADEVSLASLEHLKAKRERGEVTPDVL FT RDVSFHVQAGTLTALVGPSGAGKSTITHLVSRLYDPNSGTVRVGGHDLRDLTFDSIREA FT VGVVSQDAYLFHDTIRENLLYARPTATEDELIEACKGAQIWDLIESLPLGLDTVTGDRG FT YRMSGGEKQRLAIARLLLKEPRIVVLDEATAHLDSESEAAVQRALKTALRSRTSLVIAH FT RLSTIREADQILVIDGGGVRERGTHDELMAKGGLYAELYHTQFADPRINEAKPEREDEL FT DEPEPEPVAYMGFGG" FT misc_feature 34180..34998 FT /note="Pfam match to entry PF00664 ABC_membrane, , score FT 72.80, E-value 7.1e-18." FT misc_feature 35278..35832 FT /note="Pfam match to entry PF00005 ABC_tran, , score FT 215.90, E-value 5.8e-61." FT misc_feature 35299..35322 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT misc_feature 35611..35655 FT /note="PS00211 ABC transporters family signature." FT CDS 36003..>42369 FT /transl_table=11 FT /gene="CZA382.31" FT /product="putative peptide synthetase" FT /label=CZA382.31 FT /note="CZA382.31, partial CDS, probable peptide synthetase, FT len: >2122aa; previously sequenced therefore identical to FT TR:O52819 (EMBL:AJ223999). Similar to many other peptide FT synthetases eg. TR:CAB38518 (EMBL:AL035640) from the FT calcium dependent antibiotic biosynthesis cluster of FT Streptomyces coelicolor (7463 aa) fasta scores; opt: 2077, FT z-score: 2107.4, E(): 0, (39.1% identity in 2260 aa FT overlap). Contains 2 Pfam matches to entry PF00501 FT AMP-binding, 2 Pfam matches to entry PF00550 pp-binding, 2 FT Pfam match to entry PF00668 DUF4, 2 Prosite matches to FT PS00455 Putative AMP-binding domain signature, 2 Prosite FT matches to PS00012 Phosphopantetheine attachment site and a FT Prosite match to PS00017 ATP/GTP-binding site motif A FT (P-loop)." FT /db_xref="GOA:Q9XBC2" FT /db_xref="HSSP:1AMU" FT /db_xref="InterPro:IPR010071" FT /db_xref="UniProtKB/TrEMBL:Q9XBC2" FT /protein_id="CAB45052.1" FT /translation="MTMTSAARTAPTVLDLFARHVDRTPDAVAVADGDRVLTYRELDEL FT SGRLSGRLISRGVRGGDRVAVMMDRSADLVVALLGVWKSGAAYVPVDAAYPAPRVAFMV FT ADSAVSLTVCSAATRDGVPEGIESIVITDEDASDTSVATVRPGDLAYVMYTSGSTGTPK FT GVAITHGTIAELAEDPGWVMEPGEAVLMHSPHTFDASLFEVWTPLSLGARVVIAEPGSV FT DVRRLREAAAAGVTRVYLTAGSFRAVAEESPESFAAFREVLTGGDVVPAHAVERVREAC FT PGARVRNMYGPTEATMCATWHLLQPGDVMGPVMPIGRPLAGRRIQVLDESLRPVEPGVV FT GDLYLSGGLAEGYFNRAGLTAERFVADPSAPGQRMYWTGDLAQWTADGELLFAGRADHQ FT VKVRGFRIEPGEIEAALIALPDVQDAVVAAIDGRLVGYVVADGDVDPALIRERLGAQLP FT EYMVPAAVIALDALPLTANGKVDRAALPAPEFAANATSRAPSTDAERVLCGLFAELLGI FT DRAGVDDGFFELGGDSIVAMRLAARAAKAGLLVTPVQIFDEKTPARLAAVARAVPADRP FT DDAPLIALTAAEEAELAIAAPGADEIWPLAPLQDGLLFESTLDDQGPDIYQVQVILELT FT GPLDEARLRAAWDTVLRRHAELRLSFHRLASGKTVQAVHGDVTLPWRSVDLSGADDVDA FT AVEALVGLEQQERFDLATAPLVRLVLVRIAEDRHRLLVVIHHILIDGWSVAVILNEVSE FT AYTAGEQFPQQRGGASFRDYLAWLNRQDKDAARAAWRAELSGLDEPALIAPAGTATDYD FT YRATHLSPVLHTRLLEFAREQGLTVSTVVHGAWAMVLARLARRTDVVFGTMVATRPAEL FT QGVESMPGLLMSAVPVRVTLDGGQSVVDMLTDLHNRQTALMPHQHLGLPEIQKAAGPGA FT TFDTMLVIENYPRNYAGQYTYLRTIEGTHYPVTLGITPADRFKIQLGYWPGQIPDAIAE FT SLLEWFVGAIGALVADPSGLVGRVGMGTAAARGWAPPLVAGQPLPALVGQMAAQRPNDV FT ALVDRDGELSYGELWERSVKFAAVLRAHGVGSESRVGLVVGRSAWWTVGMLGVMLAGGT FT FVPVDPAYPDERKEWIFRSADPMLVVCGGTTRETVPAQFADRLLVIDEVDLAAGSDAAL FT PQVDPRNAAYVIYTSGSTGTPKGVVVTHAGLGNLALAHIDRFAVAPSSRVLQFAALGFD FT TIVSEVMMALLSGATLVVPPEQDLPPKATLTETLERWDVTHVKAPPSVLGTVDALPDRV FT ETVVAAGELCPPGLVDRLSADQRMINAYGPTETTICATVSMPLSPGQHPIPFGGPVPGV FT RGYLLDSFLRPLPPGVTGELYLAGIGVARGYLGRSALTAERFVADPFVPGERMYRTGDL FT AYWTDQGELVSAGRADDQVKIRGFRVEPREIEFALSGYPRITQAAVTVRDDRLVAYVTP FT GDIDTQAVRDDLASRMPQYMVPAAVVALDALPLTAHGKIDRRALPDPDFTAGTTSREPT FT TETERVLCELFAGVLGLARVGVDDSFFELGGDSILSMQLAARARRAGLTFTAADVFDGK FT TPERIAHLAAVESAPSEHGRSTTADGVGDVAWTPLTWMLGDGVVGARFAQWMVVGAPSD FT LTEKALVAGFAALVDTHDMLRARVVNDQGGRRLVVGERGSVDAAKLVTRVRVDGGSLDE FT AVEDAAREAVNRLDPLAGVMAQAVWVDAGPDQVGRLLVVAHHLSVDGVSWRVLMSDLQA FT ATEAVAAGRDPVLEPEGVSFRRWAGLLKEWAVAADRVGELAAWKAILGHEEQPVGARGL FT TTGQAAQGDVRSRSWVVPKAETSVLMGRAPVVFHCGVNEVLLAGLAGAVARWRGGDAVL FT VDVESHGRHPVDGMDLSRTVGWFTSAHPVRLDVAGIDLADVLAGGSAAGRLLKVVKEQS FT RAVPGDGLGYGLLRYLNGTTGPVLAELPSPQIGFNYMGRFVTSEKSGVRAWQPVGDIGS FT SLEPGMGLPHALDVNALVQDLPDGPELTLMVEWQEDLLGEAEIERLVQEWLDMLSGLAR FT QADDPAAGGHTASDFDLVDLDQDEIEALEAEHAGVGGLADVLPLSPLQHGLAFHAGYAG FT GVDVYTAQAVLD" FT misc_feature 36114..37283 FT /note="Pfam match to entry PF00501 AMP-binding, , score FT 435.40, E-value 5.1e-127." FT misc_feature 36456..36491 FT /note="PS00455 Putative AMP-binding domain signature." FT misc_feature 37515..37706 FT /note="Pfam match to entry PF00550 pp-binding, , score FT 55.80, E-value 8.1e-14." FT misc_feature 37584..37631 FT /note="PS00012 Phosphopantetheine attachment site." FT misc_feature 37797..38909 FT /note="Pfam match to entry PF00668 DUF4, , score 238.80, FT E-value 7.4e-68." FT misc_feature 39174..40346 FT /note="Pfam match to entry PF00501 AMP-binding, , score FT 477.50, E-value 1e-139." FT misc_feature 39531..39566 FT /note="PS00455 Putative AMP-binding domain signature." FT misc_feature 40575..40766 FT /note="Pfam match to entry PF00550 pp-binding, , score FT 61.30, E-value 2.5e-15." FT misc_feature 40644..40691 FT /note="PS00012 Phosphopantetheine attachment site." FT misc_feature 40719..40742 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT misc_feature 40815..42041 FT /note="Pfam match to entry PF00668 DUF4, , score 61.40, FT E-value 1.9e-14." XX SQ Sequence 42369 BP; 6959 A; 13629 C; 14673 G; 7108 T; 0 other; gatcctggtg cattccaaga agtcatcacc ccgtgaggtg atcgagtttc ttgacgcctg 60 gcagggcaga gcgccggtgg tcgtggtacc caccacctat cacgactggc acttcacgga 120 tgccgaaaac gccggagtgt ccctggtcat ctacgccaac catgccctgc gggcggcggt 180 caggtcgatg tcgcaggtgc tgagcagcat cgagtcgtcg ggagcgtcca cttcggtcga 240 ggacctgatc gcgccggtct ccgaggtgtt cgagctgacc cagctggaca agtggctgca 300 tctggagaaa cagtgatcgg cgcggacgag ttcgcggcgg cgctgctcga ccaggactac 360 cagttcttct cgggtgttcc gtgctctcgg ttggctggcg tgacctcgat cctgtccagc 420 cacgaaggcc gttacgtccc agcggccaac gagggcgcgg ccctggctat cgccgcaggt 480 gcacggatgg cgggaacacg cgcggccgta ttgatccaga actcaggtct gggaaatatg 540 gtgaatccgc tgacgtcttt ggtgcttccc tatgagatcc cagtgctcgt cgtggtgagc 600 ctgcgcggtt ggccggtggg gacggacgaa ccgcagcaca acgtcatggg aaaagcgacc 660 aagcccatgg cggatctctg tgggatgccg agcatggttc tcgaaccgtc gctgggatcc 720 ctggcggaag cgctggccag ctcgcagaag gcggaaatgg atggcaagcc gttctgcctg 780 ttggttccga aagggacagt gaagtcggcc gacccggcac caactccgtc gagcggtgtg 840 ctgagccgtg tcgatgcggt acggatagtc tcagcgcagg ctcgtgacgc cgcgatctac 900 agcacgactg gatatacctc acgtgaactg ttcgctgctg ccgatcggcc aggcaatttc 960 tatatgcaag gttccatggg acatgcgttg gccctcgggc tcgggtcggc attgcgccgg 1020 ccagatcgac gcgtcgtcgt cctcgacggt gatggagccg cgctgatgca catgggcaca 1080 atgtccactg tgggcaacct tgctccggcg aacttgttgc atgttgtgct ggacaacgga 1140 acgtatggtt ccactggaag tcagccgacc acgtccgcga cagtggactg gccggcgttg 1200 gcccgtgcca acggctatcg cgatgcctgg ttgtgtgctg acggcgccga actgcaaggc 1260 gtgttgggca aagcgctgac gcaaccgggt ccgtgcttgg tcgccgtacg gattcgggcc 1320 agtgaaaccg acgtgccgcc gcgggccagt gcggagttgc cgcttcccgg gatccgtaac 1380 aggttcgagc acgagttggc ggtcggtcct ggcggacaga tgacatgacc gatgtggacg 1440 atcagcgtcg ggtcgaggtg atcgagggcg ccggagtcgc tgcgaaacta cccgcagtgc 1500 ttcgaaaaat gcgagcccag cgtgttctcg ttgtcgcgac acgaaacgcg gtgcatcgca 1560 ccggtgcacc cgggtggctg gcgcgacacg cccacgacta cttttacgac gtcgccccga 1620 atccgcaagc cgcggatgtc gtccgaggcg cacgtgccgt gctgcgatac aagccggatg 1680 tcgtgatagg cgtcggtggc ggctccactt tggatacggc gaaggctgtc cgattgttgc 1740 cgccgaccaa ggacgaggct gagcgagttc ttcgtggaga cgagccgata cgagtggcga 1800 gaccaccgag gctcgtggtg ataccgacga cagcgggccc gggcagcgag gtcacggctt 1860 ttgccacgat ctacgtcggc acgcgaaagt actcactgga ccatccgacc gtgaaagcgg 1920 acgtggcgct gatcgatccc gcactcacac actcatgtcc gccgacgttg actgcacact 1980 gcgcacttga tgccaccgcg cacgccatcg agtcatggtg gtcactacgc tccagcgcgc 2040 cgtctcgcga tctggcacga agtgcgttgg cacgcctggt tcctatactg caaaagggct 2100 ttcgtgacac atcctctcag cagcgcgaac tactcagcaa tgccgcagtc atggcagggc 2160 aagcgattga cttgacccgc acaacggcgg cgcacgcctt cgcgtatccc acgaccgcac 2220 gattcggtgt gccgcatgga ctcgcgtgcg cattgcatct ggtttggttg ttgccgttga 2280 cgctcagtca actcgagccg tcgagttctc gcatggcagc ggacgacata ggacacatgc 2340 tcaggctcct gggcgctcgg acaactgccg aatccggagc ggcattcgcc cggctgttac 2400 ggctggcggg ctgcccgacg cggcttggtg aggtcggggt tcgcgcctcg gacttggagt 2460 tgatgttcga tgacgcgctg agcaacagcc gcgcccaaaa ccatccgatc gcgctccgca 2520 aagactcggt tctggagtcg atgaggtccc ggttgtgagc gatcgagggg agacgtcgtg 2580 aacctacgga tttccggacc gacgcccttg ccaccaaggg ttcgggccgc cctgtccacc 2640 gacatgatca gtcacaggtc gacggcgttc cgggacatcg tcgcggaggt tctcgccggt 2700 ctcactcccg tgttcggtga cccggcgact attctgccgt tcacctgttc aggtaccggg 2760 ggacttgagg cggccgtcgt caacacggtg cgtccggggc aacgagtcgt cgtggtgtcg 2820 atcgggtact tcggcacgcg aatggccgag atcgcccgga tggccggcct cgacatcgaa 2880 gtgatcgagg tgccgtgggg ccaggcggcc gatcctggtg agcttcaggc cgttctacgg 2940 cggctgcgtg acgtggcggc ggtcctggtg acccacaacg agacatccac cggtgtgctg 3000 aacccgctac ccgaactctg tcgcgtggtc cgggaaagca gcgatgcttt gctgatcgtc 3060 gacgtcgtca gcagcgtcgg ggcgacgccc gtgcgcatgc gggactgggg aatcgatgtc 3120 gcggtcggtg tcagtcagaa ggccctgatg tcgccgcctg gattggcgtt gctcggtgtg 3180 agctcgcggg ccctgaccgc ggccgcagcg aacccggctc gtcggtacta cttcgacttc 3240 accgcaatgg ctcgggccgt cgaggagaac acgaccacct atacccctgc catcccggtt 3300 ttccatgctc ttcagacggc actgcggatg atctcggtcg aaggctggga tcgggttctc 3360 gcccggcacc aacggctttc cgagcagtgc cgcagcgggc ttgccgacct ggggctggcg 3420 ttcgcggccg atcagccgta cgcctcgccg accgtgactt ccttcttcgt gcctgccgac 3480 atgcgggcga gtgacgttcg ggagcggatg gcggtggaac acaaggtaca ggtcgcgtcc 3540 gggcgagcga agtggaagga cagcgtgctt cggatcggcc acatgggata cgtcaacgag 3600 aatgatgtcg cgcacgtgct ggccgcgctc ggcgctgtgc tcgacagggc aggaggctcg 3660 tcgtgaaccg tgtgctgagc gcgcttgctc cccattcgtc gaagcggatc tctgagtacg 3720 ctcaacgcca tccgggcaca gtggacttga cagtcggcct tccggcattc ggcccgccga 3780 ggtccttcga cgagcgattg gccatgttgt cgagtgctcc gcacgtgaac gctcgacccg 3840 aggaccagta cgcgcactcg aggggagcga tcgagcttcg cgcggcgatt gcccacgtct 3900 acaagtcgga acagggcgtc gacctcgatc cggacacgca gatcctggtc accaacggtg 3960 cggccggcgc gctgtggatc gcggtcctga cgttgaccga gccgggtgac gaggttctgc 4020 tcgccgatcc tggatacatg atctacccgc cgatgatcga gttgctgggg cggcgggtgg 4080 tccgtattcc gaccagcccg gccgacggtt tccgcttgca cctctctgac ttgcggagcc 4140 gtctcaccca acgctcgcgg gtcgtcttgg tgaattcgcc aggcaatcca accgggagag 4200 tgtccagtga ggacgaactg gcggatctct gcgctttcgc ggtcgagcac gggttgtatg 4260 tggttcatga cgaagtactg gacaggttcg cgtacggaat cgaacatcgc tcagttgtcg 4320 ctttggacca ccagggcgtg ggcattgcgg tcaacggcct gtccaagcgg ttcggcatgt 4380 caggatggcg aatcggttgg ctggcaagca gttcggctgt catcgctgag gccgccaagg 4440 cacacacgtt cttcatgctt gcggtgagtc atgcggttca gctggcggcc gcggcggctt 4500 tgagcgatcc gaaagcggac ggcgaggttt ccgtttatgc cgcggagata cgtcgccgcg 4560 gcgaggtgtt ccttgccgat ctagcccgaa tccctggctt aggcaagaca acggttcccg 4620 atggcgggtt ctatgctttc gttgacgttg gtgagttcgc gcggttgcgc ggcattcgcg 4680 tggcggagtc gaccagtgcc gccgtggccg agtacctgct tcatgagtgt ggtgtggctg 4740 tcgtgcctgg ctcggtgttc ggccgggcgg gcgaggggtt cgtccgaatg tcgttcgcgg 4800 gtagtgcgga gcaacttgat cgtgccgtaa agagattggc aggctgagat ggaccgtgaa 4860 gtgagagtga tcattccggc agccggtgtc ggctcccggt tgcggccgta caccgaggac 4920 gcaccgaagg cccttgtacc gatcgcgggc aaaccgttga tctggcacac catgcggcgg 4980 cttgccaaga tgaaggtgtc cgaggtggtt gtggtcagtg gctacatgtc ggagatgctt 5040 cgggcatcgt tggaggcttg cccggacacg ccgccgttgc ggtttgtgga gaacccggat 5100 ttcgccagta ccaacagtat cgtgtcgctc gggttgacca aaccgttctg ggacacgccg 5160 ttctgcgtga tcgacgggga cgtgctggtc agctgtgacc tcctgcagcg cgtgcttgat 5220 tcgccacgcg atgtgctggc ggtggacacc agcaaggtct acgcggacat cgacatgaag 5280 gtccggatcc atgatggacg ggcggtcgac ttcggcaagg atctctcacc ctcggcccgc 5340 cagggcgagt tcttcggcgt gagccggtgg agcccggcca acgcggcccg gctggcatca 5400 gccatcgacg aactgctcgc cgcaggcaag gtcggcgagt ggtacgagtc cgcgatgcgc 5460 cggctcgctg tcgagggcgg gttggatgtg ctggacgcga cgacggacga atgggccgaa 5520 gtcgattccg ccgcggacat tcccaccgcg actgccctcg tcgaacgcga cgaggcgagt 5580 ttcgcgtagg tgcgtacagt acgaggcgtg ccaacgatcc gagccgcgac agccgaagac 5640 ctgcctgcca tcctcggcct ctacgccgag ctccacccag atgacccggt cccgtcgccg 5700 gaatccgtgc agcgcgcctg ggccgcgatc caggcacagc ccggccggac catcctggtg 5760 tccgaggtgg actcggttgt cgttggcacg accgactgcg cgatccaggc caacctcacc 5820 cgcaacaccc gctcgctgat gttgatcgag aacttcgtgg tcgccgcggc ttcccggcgc 5880 accggggtcg gctcggcgct gctgcgggaa gccgtccggc tggcacgtga ggcgggctgc 5940 tacaaggtcc agttgctgtc ccgctccagc cggacggacg cgcacgcttt ctacgaatcg 6000 cagggcttta agacgctcgc tgaggggtac cggctgtacc tctgacggtg ccgactgagg 6060 ctcggcttcg ttgaaggtcg atgggtcgtg gcctgtccct tccgttcaga ccttgccgag 6120 gacaccgttc tgacctgcgg tgcgcagggt aggtccggac gctccgggct cgagtttgtt 6180 cggattactt cgcggattgg atggggctga caggttcgca gccggtggtg gctaactcgc 6240 gaggctgttt ggtccgcaag tcggatagtc actctagcaa tgtgtccagt cgctccctga 6300 cgattcgctc ggaatgtgtc gccggtctcc cggtacgcgg caacggcctt ctgccaggcg 6360 tctttcgcct catcgacccg gcgcgccgtc cgggcgggca gctcggatgg atttcagcgc 6420 cgccggggta ttgacggtgc ctttgcgctg gcggttgacg ccccgcaggg tgtcgttacc 6480 gatcgagtag cagccatgga aataccggac accgtgggtg cggtggtagg tcgccgccac 6540 ccgatcgggc cgtcccttct cggcctagca ggcaccgccg gtggggccgg atgcccagcg 6600 gcccgaactc gtcgaaggcg aacgtgcgat ccgggaaacg ctcgatcacc tgctcgatcc 6660 ggtcgagctt ggcgtcccgg tccgggtcgg tggattcctt ccaggtcttg gtgcgctgga 6720 aggtgatgcc gcggcgagcg agcagacacc gcagcgcctc acggccgatc tggatcagcc 6780 cgccggcggt ggtgcgcagg taggcggcga gtttgcggat cgaccagcgc gtgaaggggc 6840 tggtcgagtg tcgccgggcg ggtggtggcc gtcgccgcga cgagatcgtc ctggtcagga 6900 ccgagtaggc ggggacggcc tcccgcccac tgagggccca gacaggccag accgatctca 6960 ttgaaccggt gcagcacctc ccggacagtg tcttcatcgg cgtcttcatc ggcctgcacc 7020 acctgggcga tcactgggac gcggttgccg ccggccgagg ccaggatcat catcgcccgc 7080 cgcaagcgca ccgaaccggt gctcccccgg cgcacgatct gctgcagccg ctggccttcc 7140 tgatcggtca gcctgcggac tttcaccggt tcggccacca acacctccac acatcccgtt 7200 cgacgatgtc ccatatcgaa ccggttatgc ggtgtcaccg ctgagtgaca ccccggcgaa 7260 ccattccggt cacggcacta gggcctgtat cgaagtcgag tgcgattgcc tgagctgagt 7320 tggcactgtt gggcgtgtcg atgatcaaga atgagcgagg cctccggtcg agggtttgtc 7380 gaccaagaaa aacctgaaca ccggagacct cgtggacacc ctagcggtgg cgaggcggtt 7440 cgacctgacc gacgtgcagt gggcgctgct ggagccgtta ttgccccagc cgtcgcggtc 7500 aggccggccg tcgttgtgga gcaaacgaca gttgattgac gggatccgat ggcgggtgcg 7560 caccggtgca ccgtggcgtg acatgccgac gatgtacgga tcgtgggcag ctgcctatgg 7620 gctgtttcgg cgctggcagc ggacgggtgc ctggcaacgg atgctgatta cgctgcaggc 7680 actggccgac gcggccgggc atatcacctg ggatgtcagc gtggactcca cgatcgctcg 7740 ggcgcatcag catgccgctg gtgcgcggaa aagggggatc tgcagaccga accgccgggc 7800 gggatcacca ccgagccgga ggatcacgcg ttgggccggt cgcggggtgg actgaccacg 7860 aactgcatct gggctgcgag ccaggccaga agccgttgtc gatcgtgctg accgctggcc 7920 agcgcggcga cagtccgcag ttcatccctg tcctggcggg tatccgggtg cacggttgat 7980 cggcggccgg gccagaaccc gcccggatcg tgtcctggcc gacaaggcct acaccgcgaa 8040 ggcgaaccgg gaacacttac gccgccgtgg gatccgagcg accatcccga gcaagaccga 8100 ccaggacgcc caccgcacgg ccaaggggtc gaaaggcggc aggccaccgg tcttcgaccc 8160 cgagatctac aaacagcgtc acgccgtgga atgcggcatc aaccggctca aacgccaccg 8220 tgccgtggct acccgctacg acaaactcgc cgtccgctac gaagccactg tccacatcgc 8280 ggtgatcaac gagtggctct gatcgacttc gatacacgcc ctagtgacac ccgttgactt 8340 ttgtcgattc gttgcgccaa gtggcgcaac tttcgcgcga gtccaccgtt cttttgttga 8400 cttctgacgg aagtcgttct cttctgggag ggacggggtc gtcgcgcgaa gggcgtgggg 8460 accccttcat cggccctcaa ggaggaggcg tcatgccgcc agtcgctgcc ctgcttgccg 8520 ctgtcatcgc agtgccctta ctccccgtcc cggcgtccgc ccagcctgcc atcccgcccc 8580 aagaaccggg cgtgaccatg cgcgtattcg acgtgcaggt gccgctcaac gactactgca 8640 agctcaaacc gggccagacg cccaatgtcg acaagctgat gccggcaatc gactggtcaa 8700 gcaacgcgga cttcgggatc gctgatcgtt ttgtcaccga agtaagcgct taccttcacg 8760 tgtccacggc cggaacctac gacttccggc tcacgagcga cgatggtgca cggttcctgc 8820 tcgacggcac tcaggtgatc gaccaccccg gccgtcacgg cgccaccgcg aaagacggtt 8880 cggcccaact ggccgcgggc caccacgcac tgcgcatcga ccacttcgac gccgacttcg 8940 accaacggct caagctcgag tggcgcccac cgggcgcggc cgaatacacc gtcgtgccga 9000 actcggcgct gagcaccgac gccgacgtcg tgcgtgtcac ctcgcccggt cgcaagcagt 9060 gcgagggcgt cacggacgct cccggcgatg gtctgccgtt gaccgatgtg cacccggcct 9120 acacgctgac gaacttgcgt cccaacgggt tcgagccgca ggtcaccggg atggactggc 9180 tgccggacgg ccggctggcc atctccacct ggggcggcga ccggctgacc gtgctcggtg 9240 aggtgttcct gctcgatggc gtcaccggca acaccgaccc gtccaaggtg agcatcaagc 9300 ggatcgccca cggcctgcgg gaaccgatgg gactcaagta cgtcgacggc accgtctacg 9360 tgtccgagaa gcaccagttg accgcgctcg tcgacaagac cggtgacgag gtcgccgacg 9420 agtaccgcag gatcgcgacc tggccgttcg gcggcaacta ccacgagttc gcgttcggcc 9480 tgctgtacaa ggacgggtac ttctacgtca ccacgggcat cgcgatggtc cccggtggcg 9540 cgaccgccga cccgcagccc gtgcccaacc ggggcagcac tctcaagatc gacaagaaca 9600 ccggcgatgt gtcctatgtg gccggtgggc tgcgcacacc caacggcctg ggctgggggc 9660 ctgagggcga cgccttcgtc accgacaacc agggcatgtg ggtgccggcg tcgaagctgg 9720 tacggatcaa gcaccgcgct ttctacaacc actacaccaa cccgggcggc ccgttcgacg 9780 accagccggt gaccgaaccc gtgctttggt tgccgcacaa tgagatctcc aactcgccga 9840 gcaacccgat cgtcctgccc gacggtgtgt tcaaggacca gatggtgttc ggtgacgtga 9900 cctacggcgg cctgcaacgc gcgtacctgg agaaggtcgg cggcgagtac cagggtgctg 9960 ttttccgtat gacacaaggg cttgagtccg gggtgagccg gatcagtgtc gggccggacg 10020 gcgcgatcta caccggcggc atcggctggg caggcaactg gggccaggaa ggcaaactca 10080 agtacggcct gcagaagctc agtctcaacg gtgccaacgc ctttgacatc cacagcatgc 10140 gggccatcaa gggcggcttc gaactggagt acacgcagcc gctgtccgac gagaccgcga 10200 aagacctcgc cgcgaagtac aaggctcagc agtggcggta cgtggcaacg ccccagtacg 10260 gcgggccgaa ggtcgacgag gagaccctcg gcgtcacctc ggcgacgctg tcgaccgacc 10320 gcaagaaggt gacgctgcag atcgcgggct tgaagccggg ccgcgtggtt tacctgcgct 10380 cgccgcgccc gttcaactcg gcgtccggtg cggaactgtg gagcaccgag gcgtggtaca 10440 ccctcaaccg gctgcccgat ggcacggtgg cgccacagga gtacgaagcg gagtccgcca 10500 ggttgaccgg cgggaccggc tggaacacca accacgccgg ctattcgggc gccggtttcg 10560 tcgaccgcaa ctgggagccg ggcagcacca ccacgttcgc cgtccgcccc gcgcgagccg 10620 gtcggcacaa catcgccctg cggtacgcga acggcccgaa cccgagcccc aacccggtct 10680 cgaagtcgat gagcctgtac gtcaacggca agaaggagaa acagatctgg ctggccgcca 10740 ccgggagctg gagcaagtgg gcgacacacg tggagacggt gacgctgcgc cctggcgcga 10800 acaccatctc ctacgtctac gaaccgactg acaccggaca cgtgaacctg gacaagatca 10860 cgctgtcgat gaccaaccgg gtcacgttgt tcaacggcac caaccttgac gcgtgggaga 10920 cgacgtccgg cgccccggcg acgtggcccg tcgcggacgg gtcgatggag tcgttcggcg 10980 gtgacatccg tacgaaggaa cggttcggcg acttccgcat gcacgtcgag tggtacgagc 11040 cggactaccc gccggaggtc accgggcaag cccgcggcaa cagcggcgtg tacatctacg 11100 agagctacga actacaggtg ctggagtccc acgggcggcc tccggagctc aacggcgccg 11160 gcgccatcta tctgaagaag gcgcccgacg tgaacgcggc gacgccgacc ggcacgtggc 11220 agacgtacga catcgagttc cgtgccgcgc gcttcgacgc ggcgggcaag aaggtggaga 11280 acgcgcggat aaccgtgtgg tggaacggaa agctggtgca caacaacgtc gccatcgacg 11340 gcccgaccgg cgcgggcaaa ccggaagacc cggcccctgg ccacatcaag ctgcaggacc 11400 acggcgatcc cggcgccaac ccgcgattcc gcaacatctg gatcgaacgc cgctgacgcc 11460 tgaccggcca gcatcccgcc cgaggtggac gggatgctgg tccggcggtc agagaatgtc 11520 gacctggcag tacggcgcgc cgccgaccac ggtgcagcga acctcgtggt agtcctcgat 11580 cttgaaccac acgtcgccag ggacccagcc gtacgagctg acgtagtacc gggagacgtt 11640 ctccacctga aatccgtcgg tgtcgaacca gtagccgcgc aggtcggagt cactcttgcc 11700 agagggcagc cagtactcgc gacaggtgaa cgaacccgcg ttcctggtcg agcaacggtg 11760 actgccaccc gtgccgaact ccgcgatctt caccggccat gcggcaggca ggcggttgtc 11820 gatgttgccc caggcgccgg catcggcgtg cgcgggctga gcgttcacga gcgagagccc 11880 gatcgttccg gcgaccgcca ttacgagcga agtgacgcgt cgaaccgctt tgagttctaa 11940 gaaactcatt gtctccccat ctaggacgca atggaactgc aagcgccgcg cgaccaaggc 12000 tgatcttctt tccggcggcg gtgtcatatc tagcacccga aggtcccgtg gacagcggtc 12060 cagaccgctg aacaaacaaa cccgggcgaa agggcaagcg ggggcgaggc ccctcggtgg 12120 cggtcttcat gcacgtcaga agatttgcgg tatgtgcaca agttgttcag tgcccgtctg 12180 tgcgtcggac aactaggttg tctggtgtga cggttcggtg gccgaggccg atgcacaggt 12240 cggcgcggtt ggggatttct gcggacattc ggcggaccat ggaaggtagg gggcatgggc 12300 aggcgtgaac gtccgctgga tccagatgcg ggatcattac agcgtttcgc gttcgagctg 12360 cggcaattgc gttcggtggc cggacaacct ggttatcggg aattgtccag acgcgcgcac 12420 tattcgataa cagcgttggc cgaggccgcg ggtgggcaga cattgccgtc gctggcggtc 12480 acgttggcgt acgtgcaggc ctgcggcggc gatcggcagg tatgggagac gcgctggcgg 12540 gagcttgctg aggaactggc actcgccaac ggggactcgg ctgaccccga cgcgtcgcct 12600 taccttgggt tggccgcgtt tcagcccgac gacgccgacc ggtacttcgg tcgcgacagc 12660 ttggtcgagc atgtcgtgca caaggtcgcc cagacgccgg tcgtcgcggt gttcggagcg 12720 tcgggcagcg ggaagtcgtc tttgatccga gcgggcctca tcccagcgac acgcacgcac 12780 tccgcgttct ccgggaacca gtggacctgc gttctgttga cccccaccag tcagccgctg 12840 cgagaactcg cccacgccgt cacggaactg tgcggcaccg aacctgaccg cagcgaaccg 12900 ggctggctcg gccgggcgct gcaccacgcg caccaccctc gggttctgct ggtcgtcgac 12960 cagttcgagg aattgttcac cctgtgtccg aacccggacg aacgggtcga gttcatcgat 13020 gccctgctgg acgccgcccg cagccccgac gggatggtgc acgtcgtctt gggcgtccgc 13080 gcagacttct acgggcactg cgcgacccac cctggcctgc tgaagacgct gggcgaaggc 13140 gcacaggtgc tggtcggccc gatgaccaag gacgagctgc ggtccgcgat caccgggccc 13200 gccgcgatgg ccgggttgac tgtcgagcgg gaactcgtcg ccaccatgat cgccgacatc 13260 gccgacgaac ccggcgggtt gccgctgctg tcacacgcac tgctggaaac ctggcggcac 13320 aggcgcaaca gcaccatgac caaagcgggt tatcacgtgt gcggcggcgt acacggcgcg 13380 ctcgctcaga ccgccgagcg cctctacgcc gagttcgatg ctgcggaaca agaggtggct 13440 catcggatct tcctgcgtct gaccgcgctc ggcgacggca ccgaagacac ccggcgccgc 13500 gcgcgccacg gcgaactggc caccgttggc gattcgagca ccgtgacccg ggtgctggac 13560 aagctcgccg ctgcccggct cgtcgtcatc ggcaccgaca gcgtcgaggt cgcgcacgag 13620 gccttgatcc gcgcctggcc ccggttgcgc cgctggctca ccgacgaccg cgagggcgtg 13680 ctgctgcacc gtcggatcac cgatgcgacc cagctctggc agtcatccgg acgtgacccg 13740 gggttgctct accaggccac gcaactcgat caggcgatcg cgtgggccga tcagacgcac 13800 cgcgcgtcgg ctctcaacgc cgacgaacga gagtttctcg atgcggcaac cctgttgcga 13860 gacaagcaga tccgatcccg caaacagcgc acgctccgcc tgcgagtggc cacggcagcg 13920 gtggtggcgg tgctcgccgc tgcctccgtc atcacgtggc agcagcgcaa cgaagcccgt 13980 gaccaacacc gggtggcggt cgcacgccag cttgtcgccg aggccaccgc gctgcgggaa 14040 atcgatccgc tgcgggccgc gcaactcagc ctcatcgcgt ggcagatcgc gccggacgtc 14100 ccggccactc gggacagtct gctcagcgtc caggcctatc cgttgcccac tcggctgctc 14160 ggtcacaccg gtgaggtgcg cgatgtggcg ttcagcccgg acggccgcgt cctggccacg 14220 gcggctggag actcgagcgt gcgcttatgg gacatcgcgt cccgccaacc gctcggcaac 14280 ccattgaccg gtcacaccgg catggtgaac gggttggctt tcagtcccga cgggacgacc 14340 ttggcaacag cgtccgctga ccggactgta aggctgtggg acgtcgcgcg tcacagaccg 14400 atcggtgagc ccatgtccgg gcacacgaac accgtcacca gcatcgcttt cagctccgac 14460 gggcggttgc tcgtcacggg cagcgccgac ggcaccgtcc gaacgtggga catcaccagc 14520 cgaacgccga tcggtgagcc gatggtcggg cataagggcc cgatcaccgc agtcgcgctc 14580 agcccggacg gcgtcacggc ggccacgtcg agcaacgaca agacggtgcg gctgtggaat 14640 gtggcgaccc gagctccgat tggcgatccg ttgaccgggc acaccagcgt gaccaacggc 14700 gtcgcgttca gccctgacgg ccagatcctc gcgtcgacca gcggtgacaa gactgtgcgg 14760 ctgtggaatg tggcgacccg ggccccgatt ggcgatccgt tgaccgggca caccaacgtc 14820 acctacggcg tcgcgttcag ccctgacggt cggactttgg ccaccagcag ctgggacaag 14880 acggtgcgga tctgggacac caccagccga cggcagcagg gcaccgcgct catcgggtcc 14940 acgagcagcg tcttcaatat cgcgttcagc ccggacggtt ccgcgctcgc aggcggcgac 15000 tcggacagct cgacactcgt ctggtcactg cggggaaccc ttgtgcccgc gcacgccgac 15060 gccgtctacg ccgtggcgct gagccccgaa ggccgcgtcc tcggtaccgg agcggacgac 15120 cggaaggtgc gactgtggga gacctccaca cacagagaac tcgtcgcgcc actcaccggg 15180 cacaccgccg aagtccgctc gatggcgttc agcccgcagg gcgggatcct ggcgaccggt 15240 agctgggacg gaactctgcg gctgtgggac gccgccaacc gcgcgccgat cggctcgccc 15300 cttactgggc atgtcgactg ggtccgtggc ctggcgttca gtcccgatgg gcacttcgtg 15360 gccaccgcgg gcatggacat gaccgttcgg ttgtggaacg tagccactcg cgcgcccttc 15420 ggtcctccgc tcaccggaca cacgaactcc gtgaccggga tcgcgttcag ccccgacggc 15480 cgcagcctgg cgaccgccgc caacgacaag acgatccgtc tgtgggacgt gccctctcga 15540 agcccaatcg gggaaccgtt gacaggccac acaagcgtgg tgcgcgatgt cgtgttcagc 15600 cctgacggca agcttctggc cagcgcgggc gacgacaaga ccgtccgcct atgggatgtc 15660 gccagccgca cgctgatcgc cacgctggaa ggccacaccg gcgaagtcct caaactggct 15720 atctcaccgg acggccgcga gctggccagc acatctctgg acaaaacggt tcgactgtgg 15780 gacacggcga accggtcgac gacgacggtc ctcagcgcga gcaccggcct cgcgggcgtc 15840 gcctataccc ccgacggcct ggtgaccggt ggtgtcaccg gcaacgtcct gctgtggacc 15900 accgacgtca cacgtcttgc cggccaagtg tgtgcggcca ccggttctga gctgtccgac 15960 gatgagtggc gcaggtattt gccgacgtgg ccgcggatga aggtatgtgc cggaacgtga 16020 gtccgctcag gaaagcaccc ggtaggtcac gtgcgtgacc gaggtcgtgg cccgcgactt 16080 cacttgctcg agcttcagcg gcgggacgcc ctcgaacagc cgtgtgcccg cgccgagcgt 16140 gaacggcacg atgtgcagcc gcacctcgtc gatcaggccg gcggcgaggt actggttgat 16200 ggtggtcgcg ccgcccagga tggtgacttc gccgtcgccg gccgccgcac gtgcctgctc 16260 cagtgccgac tcgattccgt cggtgacgaa gtgatacgtg gtgccgccgt ccatcggctg 16320 cgggtcgcgt tcgtggtggg tgagcacgaa caccgggccg tggaacggcg gattgtctcc 16380 ccaccagccg ttccacggcc gatcccactc accacgcaca gggccgaaca tgttgcgccc 16440 catgatgaat gctgtggcgg cggtcatctg gtcgatctcg gcctggttct cctcgggaga 16500 gtcgaacatc caggcgtgca gcttgtcgcc cgtgccgtcg ccgccgtcgt cgccgaacgg 16560 gcgttgctcg gtctggttgt gcccggccga gtacccgtcg gccgagatcg tgatgttgca 16620 gttcaccgtg gccatagtgt tcctcctgct tgtggggacc ttcgcgccat gcagactcac 16680 gagacggcag aaactcatcg ctgtcgatag cctggctacg gaaatactcg gacgagcggg 16740 cggagacaga tgagcgagac cgatccgcat atccacgtcg agcagaaggt gctggaagcc 16800 ggacccactg tccgcaacat gatctcgtcg atgctgggcc gcgtgaccga cgcgccgagc 16860 gtcgtcacca ccggctgcgg aatccaggtg ccctacgcga tgacctcgca tcgtccggaa 16920 agcgtcacct gcctagcctg cagggaccat gctcaccggg agtacctgcg cttcgccgat 16980 cagttcgagc gcctgggcca aggcgcgatg tccggcctga acatcaccga ggaccaggtg 17040 gccgaggcgg tggaacggct ccgggacctg gcgaagaggt tctccagctg atgcttctga 17100 ccacagaagt cggcccggat cagtaccgta cgtgtttccc gccgtcgacg atggcttggg 17160 cgccggcttc ggcgagggcg agtgcgatcg cgcggccgat gcccgtaccg ccgccggtca 17220 ccacggccac tgtgtccttc acgcgcatcc cgttcagatt cccctcaacg ttgtcagcac 17280 accgttccgg tcgagctggt gcatggcgtc ggtgagcagt tcgccgaaca cgcgggaatc 17340 ccgcaacgcg gggcgtgcgg cgaacaggca gtcgggtgtc tcacgctcgt gacgcaggaa 17400 accggccaag gcgagacaga tcatcctcgg ctccgcaccc gattcgagaa gttcggcagc 17460 ggggtcgagc agacgttgcg gaagcttgcg cacaccgtcc gcggcgatct gagccaggcg 17520 gtgcgtgatc cgcggattcg ccaggcgctt cagcaaacca tcgatgtcga ccggaatccc 17580 gaagcgggcc agggacgctc cggtttcctc gcggatcaag cgctcggcgt accgggcgaa 17640 ctccgggcga gtcgccactt cggccgtgct cgtgcagcct gcgagcagcc cgaggtaggt 17700 caaggcggag tgggtgccgt tcaccagacg aagtttggcc gcctggtggg gtgttatgtc 17760 ggcgaccaac cgcacacccg ccttgtccca ggcgggtctg cctgcggcga aatcgtcctc 17820 gatcacccat tgccggtacg tctcgccgac gaccgcggcg cggtccagca ggcccaggag 17880 tgaagccacg ttggcgatgt ccgcgtcagt cgtggcgggc acgatctgat cgaccactgt 17940 ggacggacac cgcacctgtt cggcgatccg ttcagccagt tcgggttgcc ctgacaacac 18000 gcagaaatcc cgcaacagtc ccgcgaccaa ccggccgttg tccggcaagt tgtcgcaggg 18060 cacgaccgtc agcccgctgt gttcacgtgc tttcaggcca cgtatcagtt ggccgatgac 18120 cgtccgcggt ggtcggccgg ccacatcggc ggcgacttcc gggtcgtcgg cacgtaaccg 18180 cccggtggcc gggtcgtggc gataccctgc ctcggtcacc gtgatggtga cgatccgggt 18240 ggccgggtcg gccagtgccg cggtgacttg gtccggttgc tcggacgcca gcaggacatc 18300 gcgcacgctg tccaccactc gcaggtcctc gtgctcggcg tcgcgctcgg tcaccgtgaa 18360 caggcagtcc tgtgtggaca tggcgtcgcg gacggccggg ttgcgctggc cgacggcgca 18420 gatcgcccag tctccgggct cggcgagcat cgcctcctgg gtgaacaccg cctggtgcgc 18480 ccggtggaag gcgcccagtc ccaagtggac aatgccgata ccggcccggg gcgaggccgc 18540 gggatacgtc gatctggaca gccggggaac cacgaggcgt caccgggtcg cgtcgatcac 18600 agtgatgtcg acgtccttgc tttccttgga caaccagaag gccacgaacg agatcgccgc 18660 cgtcgcgatc atccagagcg cgaccagcca gcccttcccg cctgcctgcg ccaccagcgc 18720 cgcggcgatc aagggggaga agccgcccag tgccgcgccg atctcccggg acgcggcgaa 18780 cccggtgtaa cgcacccgtg cgccgaacag ttccgcgtag aacgccggct gcacggcgat 18840 catcggtgcg aaccccagcg atgtcgccag caccaatgcg atccagatca gcaccggttc 18900 tcgggtatcc agcagcagga agaacgggaa cgcgaacgcc gcggtgaaca ccacgctgaa 18960 caggttcagc ggccgtcggc cgacacggtc ggacaacgcg ccgtacaccg gctgcaacgc 19020 gatgacgatg acgctgaaga tgatcacgcc ggtgagcgcg acccatcgcg gcatggccag 19080 cgtcttggtg atgtacgtca ggctgtatgt ggcgtagatg taaaccactg cggtgtcaca 19140 gatgtgcgcg ccgatgccga tcaggaagtt gcggggatag tgccgcaacg cgtccagcac 19200 aggcatcttc accgtcgtgc gccgctcgct catctgctgg aacaccgggg attcggcgac 19260 ccgcagccgt acgtacaacg ccaccgcgat cagcacgaaa ctgaacagga acgggatccg 19320 ccacgcccag tccagcacgg tctgcctcgg cagcagctcg atcagcagga acaccgtgac 19380 gccagacagg agtccgattt ggacacctgt ctgcgcgaag gacgtgaaga acccacggcg 19440 ccgcgccggc gcgtgctcgg ccagcagcgt cgaggcaccg ccgaactccg ctcccgcgcc 19500 gaggccctgg cacatccgta acacggtcag caggatcggc gcggcgacgc cgatgctgtc 19560 gtaggtcgga agcagcccga tcagccctgt ggacacgccc atcacgagcg tggtcagcac 19620 caaagtggac cgacggccga tccggtcgcc gaggtgaccg aacaggaatc caccgatcgg 19680 ccggaccgcg aagcccacac cgaacgtggc gaagccgatg atgacgccca tggccgggtc 19740 gcccgtggtg aagaacaatt cgttgaacac gagcgtgacg gcgaaaccgt agatgaagaa 19800 gtcgtaccac tccagcgcgg tgccgaccac cgaagcgccg accactcggc gcagttctgt 19860 cggtgtggtg tcctgaccgg ctccgtcctc gttgacggct ctggtcatgg tcactcctcc 19920 tctgtcctca gtagagcgtt gagttcgcgc caggtgttcg ccgtgacggg aatgccgtcc 19980 ctggcccgct caagccggat ccgctcctcc ggctcgccgg gaaccagcac ctcgctggcc 20040 ccttcggcga gcggggtctc ggcgagcgcc tggcagaacc gctctgtttg ggcacgaaac 20100 tccggtaccg gaaggaaagc ggcgatgtcg aaggcgacca ggactgtgcc ccagccctcc 20160 cggaagccgg gcatgctgcc gatgccgatg cccgacagca gtccgccgac gatctcgatg 20220 agcacactca gcccgtagcc cttgtggccg ccgaacggca gcaaagcgcc gccctggtag 20280 aagtccgcgg gtgtggtgct cggccgtccg gccgcgtcca gcaccaggcc ttcggccacc 20340 tgctcgcctc ggtccctggc cacgcgcagt ttgccttcgg cgataccgga cgtggcccaa 20400 tccatcacga tcggaggctg gccgggccct ctggggacgg cccaggcgag gggattggtg 20460 cccaggcgtc gttcccggcc gccgtacggc gcgaccgtcg ggtcggcgtt gccgaaggcc 20520 agcccgatca ggtcctgatc ggccagcatc gcaacgtatt cgccgagtct gccgatgtgg 20580 ttgcactcgc gcacaacggc cacacccgat ccctggtgcg gcacgaggga gagcagctca 20640 cgcaccgcgc gccggacggc gagctgaccg aacgcgcgac gcccgtgcac cacaacggtt 20700 cccggccggg tggtctccgc cttcggctcg gcccgcggat cgatcagtcc agtgtggatc 20760 cgcttgacgt agtcgatgac cctgcggacc ccgtgcgagt cgtggccgag cagatcggaa 20820 cccaccagcg aacgcgccac cgtctcggcg tccactgtgg acgacccggc ggcgacgagg 20880 atccgggtgg ccagcgcctc cagctcggcg gcttgaacgt tcatcgttcc gcctcatgga 20940 acggcattcc atcctgactc tcggacatag tgccacgtat cacccactcc tgtgaagtgg 21000 gtcactaggc tcagtgcgct ccgagagcct tggacacagc ctcggcagcg gcggtgacct 21060 gcgcgggaag gtcctcgacg accggcgcaa gatgcaccaa cgcggcagcg gacagcccgc 21120 cgatcacgcc gccggtgtgg tcgaacaccg cggcgccgac agcgcggaca ccggcctcgt 21180 tctcttcgtg atcctctgcg tagcgacggg cccgcacagc ggcgagttcg ctgagcaacg 21240 cgggtgcgtc ggtgatcgtg ttctgcgtgc gtgcgggcag gccggcacga gcggctatct 21300 cggcgacctg gtcgtcggac atcgtggcga gaatggcctt gccgatcgac gtgcagtgca 21360 gcttcaggct catcccgacc cgcgaggcga ggtggtacgg cttggcgccc tcgaccttgg 21420 ccacgtacac ggcctcatca ccggaaagca aagccagatg cacggtccat ccagtgcgtt 21480 cctgcaggtc acgcaggatc ggccggacct gctcggcgat gtccagacgc tgcaggaacc 21540 gcccggcgag gctgaggatg cgggggccgc agacgtagtt gccctgcccg tcggagcgcg 21600 cgaagccgtg ctgcaccagg gtttgcagga tccggtgcac ggtcggcttc ggcaggcccg 21660 cagcgccggc gatgtccgcg atccgggcgt ggtcggcgag cgcctccagc acgatcaacg 21720 tcttgtccgc cgctgactgc ggactcttgc caaccatgtg ccccaatgta gctgtcgtcc 21780 agcacgcagc cgggcaacca ggatgccgac gccgaggagt accaccagac ccagcaccaa 21840 cggcaccggg ccgacggcgt ccacccactc ggagagcagc gcctgaacct tgcccgcgcc 21900 gtccacgatc gggtcgtccg ccgagcctcc ggcgtggaac aggcgcagtt cgtagacgcc 21960 gtaatagccg atgtacagcc ccgccagcac caggatcgcg ccgccgatgc ggttgacgta 22020 cggcagaacg cgccggaccc acgtggtcac ggcagtgctc gcgagggcga ccgacaccgc 22080 gagcacaccg acgacaaggg ccatgcccag cgcgtacacc agatacgccg cgatgccggt 22140 gacgaccgaa ccactgcgaa aggtctggct ggtgactgcc aggaacggtc cgatcgtgca 22200 ggacagcgac accaccgcgt acgcgaggcc atagccgaac atcgagctca gccgcgcggt 22260 gggcgcgccc ttgcggggtt tcgggacgag cagcgtgatc tgtttgcccg ccagcatcca 22320 cgccccaagc cccaccatga cgacgccgat cactacggtc gccgcgggca gatactcctg 22380 cacggaggaa cccagcggcg ccacgaccag gccgaacgcg ccgaacacgg ccaggaagcc 22440 caatgccatc aggccagtga cggccaacgc ccgccacacc gcgttcatcg tgggacgcga 22500 ctcgcccgag accaccagcg tcagataggc gggcagcatc gcgaatccgc atgggttgac 22560 cgtggcgatc atcccggcgg ccagcgcgaa accgagggtg tcgaagtcca tgtcaggccg 22620 cggtcagtgc gttgacccgt tcagtcagcg cggattccga cagttgctgc ttgaccacgt 22680 cgaccttgcc gtctgggctg atgaacgcgt acgcgggttg ttgggtcacc ccgaaccggg 22740 tccagatcgc ggcgtccagg tcggcgagat gcgtgaaacc actgaccttg tagtcggtga 22800 cgaacttctt catcgcaggc agcgcgtcct gcgcggcgac gccgacgaac gtgaccttgc 22860 cgctggtggc ctgcgcggca gcggccaccc ttggcgcctc cgctcggcac ttcgggcacc 22920 acggcgccca gaaccacaac acggccttct tgccggccag gctctcaccc gagaagctct 22980 gcccgtccac ggtctgcacg gtgaacttca gctggtccgg caccgaaggg ctggcctgcg 23040 tgcttgtcgt cgatgtccca gtgctcgtcg tctgcggtgg cgcggccgag ttcgtgcccg 23100 gcgcggttga gctcgtgtcc gtgccgcacg cggcgagcga ggtgagaatc gcggcgagaa 23160 cggctcctgc gattcgacgg cgaagcatcg aagacctcct tggtggcggg gagtcgatcc 23220 ttgcgcacct ggcggcccgc ggcgacgtgc tcgcgtatta cggagttgtg acgtgtccca 23280 tttgtccatt gcggacagtg cgtggaggtg ggctgcgtgg aggtgggcgg cgtgaaggtg 23340 ggctggcgct gcgcaacggg cggggagacc gtcgcgcagc gcgccacgcc gacctgggtg 23400 aggcggccct gccccgcctc acccggcggc catagagttc ttcgtgttgc cgcccgccgt 23460 ctgacgcggg ctcactcgga tggccgagta gatacctcac ggcaccagcg gtggaccgtc 23520 gatgtgccac cgggcgcatc tcgttcagcc ggtccggccg gttatccggc gatcacttcc 23580 atcccaccgt caccttcacc gacgcccacg ctgacttcgg cccctgagaa cgcgtttcac 23640 agctgccgga cacgcagtac gccggtcagc atcgggaggg tgaattcgcc ctcgttggtt 23700 tctggtctgc tcgcgaggaa agcgcggatt cggctgagcg tggcccgtcg ttcctgttct 23760 ggcatgacca gcagccctgc gcgtgtcgcg agtgtcgcga cgagggagtc ggcggtgcgg 23820 cgttgcccgt gcgggaactc ggcctgctcc ggcgagccga accgcgcggc cacgccagtg 23880 tggggacgat gcaagcctgt cgtcgcggcg cgccagctgc tgaaggtgtc acgcgagccg 23940 atggccgcgc ttccgccgac ccgttcgagt ccggcaaccc agtcgactcg gttgtccatg 24000 acgttccaca gaccggccag gatgccgccg ggtgcgagga ccctcgctat ctcgggtccg 24060 gcgacggaca tgtcgaacca gtgcagagcg tttccggcca gcacggcatc gatggacgcg 24120 tccggcagcg gtatcgcctc ggcatttccc ggcagggcac ggacagtcgg cactgcgcgg 24180 cgcagctcgg tcagcattgc cgggtcaggc tcgaccgcga tgacctcggc gcccagcgcg 24240 accagtgcgg cggtcagctt gccggttcct gcaccgagat ccagcactcg cgggccgggc 24300 gcgtgctcca gcgcccaacg cgccgcggcc ggcgcgtagt ccgggcggtg ctcggcgtag 24360 gacgccgccg cagcgccgaa cgacgaggca tgaagcaacc gcacgtcctg ttccatgcga 24420 tcacgctatc catggctcaa cgtcattcgg ctgccgcggc gacgagttgg tcaccgagtg 24480 gcgtgcggcg gtagaggacc attcggccgt cgcgccgggc ggtgacgatg ccggccttcg 24540 cgagggcctt gaggtggacg ttcaccgtcg gtggtgcgga gccgagctgc gcggcgagct 24600 gggttgtcga catcggcagg tccagtaggg cgaggatggt tgcccgtgcg ccaccgatga 24660 ctgcggcgag tggtggctcg gcggtcgctg tccggccgga ctcccagagt gtgccgaggc 24720 cgcgaggtgg ataggtgagg ctgggcatcg ggtccgccgt gctgaccagg acgtccggcc 24780 aggcgaacgc gcacggcaca agcagcagtc ctcggccacg caactgaagg cggccttcga 24840 agtacttcac gatcgtcaac agatcaccgc ggaaggcgac cgacgggtgc agggaccgga 24900 acagtttctc gacgccgccg gatgcgagtt cgtcgagccg gtgggcgaga tccgcgtgca 24960 gcagtgcgtt cagccgcggc cagtgtggcg cgatcgcgac gtcccagtag cgctcgagct 25020 ggctgacgat cgtgcgcagc gcccgctccg gatcgtcggc gagctgcagg atcaacgcct 25080 ctcgcctctc gcggcccggg ccttgctgag cgatgtcgtg cctggcgagg tggtcgagtt 25140 cgtaccggac gacgtcgagg ggcgtcgcgg cgatttcggc gagcccgtcc gcgatgccgg 25200 tgctgccgcc ggacgggagc gggccgagga aatcgggcag gtagccctgt ggccgcacca 25260 acgccgaaag caactccaga tccacggttt cggtcaggtc ggtctcggcg agccaaccga 25320 gccaccggcc gtgcagtccg cctttgcggc ccgcgctcag cacgcgcagg ctcttgacgg 25380 cttcgccgat cggcgacatc gcgaacctga tcagccggta gtcctccgcg gtgaactcca 25440 gctcgatcac ggctgaagtt taggcctgag cctaatcctg gtcgaagtct tcgactgggg 25500 gcagcgtgtg tgcccatgag cgagcttgcg agcgaatcgt tcagcacagt gcgtccgctc 25560 atgcaacgcg tggggaccca cagcgaggag cgggcatgag cgagcttgcg agcgagtcat 25620 tcagcacagt gcgtccgctc atgcaacgcg tggggaccca cagcgaggag cgggcatgag 25680 cgagcttgcg agcgagtcat tcagcacagt gcgtccgctc atgcaacgcg tggggaccca 25740 cagcgaggag cgggcatgag cgcattggac gacttactgg ccgcgtatga gcggctccat 25800 ggcgccggtc cggagttcgg tggtgatgag gagggcaacc atggattgac caaccacggg 25860 ccgatggccg tcgaggtgat ggtgcggcgg gggttggaca taccggtgga gaagtggctc 25920 gacggatacg tcggccgcct cgacgagctc ccgacggctt cgcgccgtat cgacgccgac 25980 gactggcgcg acgcactcgg cgatcaccgt cgcatcgctg actggacggc ctacttccgt 26040 gcggaactgc accgcgcgcc atggcacgac gtgctcgcca cgtggtggcc gcgactgccg 26100 cccggcatcg ccgccggctc gacgcacggg gtgatccggg tggggcacgc agtccgcacg 26160 ctcatgatca ccgatcaccc ccatgtccac aatgaactcg cgaacggaat ggcgttctgg 26220 gcggcacgct ggcgtccgat cccgacggcg cggggcgaag gcacgctcac ccctgccacg 26280 gcactcgacg cgctaccccg gctgcccgac cagaccggtt tcatcgcgca ccgaatcagc 26340 cgcctcggca cgcttcccga gtggccgggg gcggtcgact cgctgcgggt gccggacgat 26400 cccgatgcgg tacgtgccac gttgacccaa ctcatcgacg ccgcgaccct ccggtatctc 26460 gccgtcggtc gcgacgctcc cgtgctgctg gtccacaccg cgaccgcgcc gaacgccgtc 26520 ttgcactgtc ttcctgtgct cccgcagcaa ctctggcggc cgagccttgc cgcggcgtgg 26580 accgcgacgg cggcgatcac cgtcatgtac gccggccacg ccgaccacac cacccctacg 26640 acggtcacgg gctccgacct cgcgggcaac ctgcttgacc gggcagccac acaccgcgac 26700 gagcacgtgc tcaagttcgc cgacaccgcg accgagtcgt acgcccgaac gggtgatcgg 26760 gcgacgatcg cggccgcgca tctcgccgcc gacctgatcg ccgcgcccgc ggcatgaccg 26820 acacaccaac aaggcacacc aacacaagga gagaaaccat gcgcacgctg atctcgacct 26880 cgttcgtctc actggacggc aagctcgacc cgaccggggg agacccggca ctgcacagca 26940 ccaagtggac gttcaagacc gtcgacttcc tgccggaggc ctacgagatc aagggccggg 27000 aacaggagga ggccggggcc ctgctgttgg gtagggcgag ttatgaactg ttcgcgcccg 27060 tatggcctgg gatggcggag ttcgcccgct acaagggact gccgaagtac gtcgtctcca 27120 ccaccctcac cgagaacgac ctcgtcgacg actggggcga caacaccatt ctccgctcgc 27180 tcgacgaggt ggccgaactc aagcagaccg agggcgaccc gatcctggtc cacggcagcg 27240 cgaccctcaa ccgggcgctg cacgaggccg gtctcatcga ccgctaccac ctgctcgtct 27300 tcccgatcct gctcggcgcc ggcaaaccgc tgttcagcga cgccgacctg cccgccaccc 27360 ggctgaagct cgtcgagcac gaggtctacc cgaacgggat ccagaagcag gtgttcgacg 27420 tcgtccgttg agccgagcgg actccacccc gctggctccc gcttcccttg ccgagcgtcc 27480 aagtgccaag aatgtgaggt tggtgcgcaa ggtggacagc tcgttggccg ggagccggca 27540 aacggcccaa tctacgagcc cgcgcatatc gtcggcatat cgaaaatcgc atacgtgcag 27600 gcaacaccac cctgcattga ctgtatgcat ggtctacagg caatccctcc ccgagctcga 27660 ggatgcggca ccgcccgagg aggctgcccg gtggacgagc agggcgcgct gaccggacgc 27720 gcgcccaacc cacgcatcct cacgaacgtg aaaaatcacc gttttcggcg gtatgatcag 27780 cccgatcgca gcccgatcga gttcgggccc gctcgccaac gacctgccga cagcggtcaa 27840 gtggctccct acggcgtcga acaccagacc cgcactcacc agacgacgcg gtcgcgcgct 27900 cgtcccttca ccaccatcgg actcgagtga tgaccggccc gtctggtgcg acgggcttct 27960 gccggtgtgc ttgatcggga acccccaaac ccgagatccg caccggcaac cgaaggtggg 28020 acgcacgaac ggcccccgca gccaggagtg cgtcccacct ccggcttcat ggcgccgcac 28080 gcaacgaggc gactcgccgg cgatcgccca ccacgaggac aagacggcca gactccggcc 28140 gggccggaat cggtgaacgc atgaaatgga acggtcgaag acctttgtgt cgtgagatca 28200 aataagtgtc atgcgggatc gggggaaagc gcgttcgatc cgcagatagt gaaggatcgg 28260 caacgcaggg tgagacctcc cggtacgtcg ctgagatccg tgccgctgct ctcgctgaag 28320 aagcgcgatg ttttggatca ccagcggggt gatcgcggta atgaaggcgg tccaaccggt 28380 cacttgacgt ggcctgtgcg gcggtgttcg tcgacgcggt ccatgccggg gtgcgcgcgg 28440 ccgggcagcc aactggctgg tccagccgct gccggtgccg ctgtggacgg acgcgaaggg 28500 tgtactgagc gcgtggattg gtgcgccggc aaatcatcgg gcatattagt atcggtcaag 28560 cgatcggaat aaattccggc cgacaagcaa ttgggcggcg atgatccggc gattgcacaa 28620 tgcctggacg aattcgtgcc gttcctcgac ggtggcatcg agatccgggc ggatggcctg 28680 ttccgtgaac gcgatcgagt ttccgaacgc gcgcgattcg tatcccttgg tgtttcccgg 28740 cccggtaagc cgcaactgga ttcctatagt gctcgcggcc tggccccgac cggtccgggg 28800 cgtgccagtt ggacccatcg ccttgaaggc gccgacggcg gtgagccgaa acctcctgaa 28860 atgcccggtg tggaacgcgg caggtcgata ccatgatcat cccacgcggg caatgtcgtt 28920 gttcattaat tgccaacaac gatgggtcat gccatgctgc gagtgtggac ttactgggga 28980 gaacacaaga tcgaccatgt cctgaggcgt cgcattacgg cgggcgttgg cctcgatgag 29040 cagtggtttc gcggcgatca ccgccggggc aggcgcgagc ctgcccttga ccgccgtcag 29100 ttcgttggag agcaccctga tgtcggccac ctgggggacc ggcgagggcg tccgcggcgc 29160 tgcggacgtc ggcggggacc ggatcgtggc gtccaaccgc acgggtcggg cagttggacg 29220 gcgcggtgcc cggcaaacgc cggaactgct cttcgaactg tcatacgcaa cgaatacggt 29280 cgaatgcgtc tcgacggaca tggctcgtga gttggcgaac cggcggcaac cgaagaacag 29340 gggtagctgt ccggaatagg ggggtagttc agggttactg cccgctttaa catgtctgtg 29400 aaaggcccac aaaccggagt ggttggaatg cttgcgggaa gcgttctgca attcgatcag 29460 tgcgcgccta cgtgttcatc gcaccagatg atggctggga ggggcgtagt cttgcacaca 29520 tcggtaccca atgggaaccc atgagggtcg ggtcaagttt caggtgtttc aggggataga 29580 ccgcgtacgc ggtcgccttc acagagagaa agtttgagtc tgctccatcg gcgcagatcg 29640 agcatgcggc ggcaacgccg agttctgtgc cgcaccgcaa agttgacgaa gaagagatcc 29700 aatttggggg ctaggtggat ccgacgagag atgacatagt cgctctccca gtcgtcgaaa 29760 tcgagttgtc ccggctgtgt tctgactcct cgccacgaac ctcgggcgag gatccggagc 29820 acgtcgagac actgttgtcg gcagaaggga acctgccgcc gattctcgtt caccgaccga 29880 ccatgcgggt gatcgatggc ctgcacaggt tgaaggtggc gcggctcagg ggcgatacga 29940 agattctggc aaggttcgtg gacggcaccg aatcggacgc cttcgtcctg gccgtcgaat 30000 cgaacatccg gcatggcctg ccgctctcgc tcgccgatcg caagcgtgcg gcggtccaga 30060 tcatcgggac gcatccgcag tggtctgatc gacgggtggc ctcggtgacc ggcatatccg 30120 ccggcacggt ggctgacctg cgcaggcgcg gaggagaaag cggcaacgag gccaggatcg 30180 ggcgggacgg gcgcattcgg cccgtcgacg gttcggaggg ccgaagactc gccgccgagc 30240 tgatccgtgg tgatcccggt ctttcgctcc gccaggtcgc caagcaggtc ggcatctccc 30300 cggagacggt ccgggatgtg cgcggccggc tggagcgtgg cgagagcccg accccggacg 30360 gcagcagacg gctgcaagcc aagccacagc cactgcgttg gtcggggccc gacttcggcc 30420 gcgtggtgga ccgggatcgt ctcgctctgc ttgagcgtct caaggccgat cccgcgctgc 30480 ggctgaccga ggcaggccga acgctgttgc ggatgttcgc catgcactcc atcgacgggc 30540 aggaatgggg acgggtcctg cacggcgtcc cgccgcatct gtgcagtgtg gtcgccggat 30600 tcgccaggga tcacgccagg gtctgggcgg agttcgccga ccacctggaa aaccgggcga 30660 gcgatctggc agcaggatga tcatcacgtc agcaggactg cgactggggg acatggtggt 30720 gaccgagagc ggcacgatgc ggccgcgtgc ggtgtccgcg gagatacgag gggacgcggc 30780 gacgatgccg gaggggcgtg gccccgtgaa acgtcccgac ggactgactt ctcagcagcg 30840 tgaggtgtgg ctgcctcggc agcagaacgc cggccgcgac gctcgggatg cggccggtcc 30900 ggcgcacgcg ccgctcaccc gtgccgagct gcgggtggcg gcactcgccg cgcgaggatg 30960 cgtcaatcgg gagatcgcgg agcggctgtt catcacgccg agcacggtcg agcagcacct 31020 gacccgcgtg ttcaagaaac tggggatcac cggccgggat ttcctgccga cgtcgttgtc 31080 ggcggtgagc tggcaggaca gtggtgcccc gcgcaaggac ggctagcggc acaaccggtg 31140 ggtgagtggg gaaaccgacc gcctcgcctg cccacatcgg gtggcaggac ctcgcgagtc 31200 actggcgagg tcctgcccct cctgatggcg acgtcggctg tatgccgagc agttgtggac 31260 gagaccgcgg ggcaactact ttcggcgagg atcgcactcg atctcgttgc gacgcgggcg 31320 aatcagacgc ggatgtctct tctctgcgcg accacgaccg cggccgcgat catgagaccc 31380 ttcggtgagt gtcccgcatt tgctgccatg gcgtggatgt aaggggatgt cttgagcacc 31440 catcaagtgg tcttcttgtt gctcgatctg gccgtgatcg tcgtgctggc gcgtctgctc 31500 ggcgcggtgg cccggcggct ggaccaaccg ccggtgatcg gtgagctgct cgcgggaatc 31560 ctgcttggac cgacgttgtt cggcgagggg ttcgccgccg cgctgttccc gaccgacgta 31620 cgccccttcc tggccgcgtt ggcgaacgtc ggggtggcca tgttcatgtt catggtcggc 31680 ctcgaactgg aacaaaccct gttgcgtggc cggggaaagc tcgccctgac cgtgtcggtc 31740 agctcgatcg tgcttccgtt caccctcggc gtcgggctgg cgttctacct ggcgatgaac 31800 cgcccggtcg agcaccggct cggcttcctg ctgttcatcg gcgcggccat gtcggtcacc 31860 gcgttccccg tgctggcaag gattctgcaa gaccgtggga tgctgcgaac gatgctcggc 31920 gggctggcgc tgacgtgcgc ggcgatcggc gacgtgctgg cgtggtgcct gctcgcggtc 31980 gtggtgatcg tgtcgggcgg tgccagcggt accgaacagt ggctgatcgt gcttgggccg 32040 atctacgtcg cactcatgct gtgggtggtc cggccgctgc tgcgcaagct cttcacggcc 32100 ggcgtcaccg gggcactgcc gaccgtgctg gcaggtgcgc tgatctccgg cgcggtgacc 32160 gaactgatcg gtctgcactt catcttcggt gctttcctgt tcggcgtcat agtgccgagg 32220 gaaggcacgg acacgctgcg gcacaggatc atcgaccggg tggaggagtt caactcggcg 32280 ttgctgctgc ccgttttctt catcgtcagc ggcttgaagg tgaacctgtc cacgctcagt 32340 gcgacgggtc tcgtcgagtt cggcctggtg ttgttggtgg ccatcgcagg caagttcggc 32400 ggtgcgttcg tgggtgcccg cctgcatggc ctgcccgcac ggaaatccgc cgcgctcgcc 32460 acactgatga acacccgtgg cctgaccgag ctgatcattc tcacggtagg ccttcagctt 32520 ggcgtactgg accagtcgct ctactcgatc atggtggcga tggcggtgat cacgacggcc 32580 atggcgggac cgttgctgcg actgatctac ccggcctcgg tgatcgagcg ggaccaggcc 32640 atcgagcagg cacgactgtg agtgtccaca tgagaccaac tcccgcacgg tgccaagacg 32700 cctgtggccg gacatccgcc cagcgagcta agaagtaacg gtgacaatgg agaaggtgct 32760 cgttgtcggc actggactga tcggcacctc cgcggcgctg gcacttcgcg agaaggacgt 32820 gacggtctat ctctgcgaca ttgacgcgga tgccgtacgg ctggcacgag aactcggcgc 32880 gggccaggaa tggaccggcc aggacgtgga cctggcggtg atcgccgtgc cgccgcatct 32940 cgtgggggag tcgctggccg atctgcagaa gcagggtgcc gcccgggcgt acaccgacgt 33000 ggccagcgtc aaggtcgatc cgatcgctga cgcggaacgg cttggatgcg acatgacctg 33060 ctatgtgccg gggcacccgc tcgccgggcg ggagcgatcc ggtccggccg cggcacgcgc 33120 tgacctgttc ttgggccgcc cctgggcact ttgtcccggc cctgaaacgg aagctggtgc 33180 cgaacagctg gcgcgggagc tggtgtcgtt gtgcggggcg aagtccgtca cggtgggcgc 33240 gcgccagcac gactcggcgg tagcgctggt gtcacacgct ccgcacgtgg cggcatcggc 33300 agtggcagcg agcctggaga gcggcgacga ggtcgcgctg ggccttgcgg gacaagggct 33360 gcgcgacacg acgcgcatcg ccgccgggga tcccttgctg tggcggatga ttctttccgg 33420 caacgcccag ccggtcgccg gtgtgctcga ccggatcgcg gccgatctcg tcgccgcggc 33480 ctcggcgctg cggtcgggtg atctggatga cgtgacggat ctgctgcggc gtggcgtcga 33540 cggtcacggc cggatcccgg gcaagcacag tggaccggtg cgcgatttcg ccacggttca 33600 agtggttctg cgggaccggc cgggggaact ggcccggttg ttcaacgcgg ccgggctggc 33660 ggacgtcaac gtggaggacg tccggctgga gcactcgacc ggcctgccgg tcggtgtggc 33720 cgagatttcc gtgcgcccgc aggacaccga ccggctcgcc gacgcactgc ggttccacgg 33780 ctggcacgtt ccgcctgttc ctgcaacgca tcaggtttcc cagcaccggt cccagggttg 33840 tccccgctga tcgttcagac cgggttggtt tcgctgtgct gccatgtcct ttcacctact 33900 gtggtgatca acgtggaggc gtgaacgagc aggtcggtgc gtgtgagaaa gaccgcgcca 33960 caacgagaaa tgctcgctcg gatccactcg tggacatcga cctgattgag cacgattgag 34020 atcgccgact tggcgtacga gagaggtgac cggatggata tggtgttgcg cttcgagggg 34080 gtggacaaga gcgagaacga tcccgacccc tgggtgacca cggtccgcaa ggggacgctg 34140 cgccgggtgc tcggctactt ccgcccgcac gtcggcaagg tggcgctctt cggactcgtc 34200 gccgtgctgg agtcgcttat cgtcgtcgca actcccttgc tgttgaagga gctcatcgac 34260 aacggcatcg aaaagaacga tctcggcctg gtgatctgga tggccgccct gaccgccgtg 34320 ctcgccgtgc tcgccgcggg gctgacgctg gtgtccggtt acatctccgg gaagatcggc 34380 gaggggatca cctacgacct ccgggttcag gcgctcgacc atgtccggcg gctgccgatc 34440 gcgttcttca cccgcaccca gaccggtgtg ctggtcggtc ggctgcacac cgaactgatc 34500 atggcgcagc agcatttcac cggcttgctg atggcaacca ccagcctggt gatggcgctg 34560 gtggtgctga tcgagctgtt ctacctttcg tggcttgtcg ccgtcatctc gctggcgctg 34620 attccgctct tcctcgtgcc ctgggttcgc gtggggcggg tgatccagcg gctgtccgga 34680 cggcagatgg acgcgaacac cggccttggc ggactgctcc aggagcggtt caacgtgcag 34740 ggcgcgatgc tctccaagct cttcggccgt ccgaacgagg agatggccga gttcgaggac 34800 cgtgccagcg ggatccgcaa gatcggcgtg agcctttcgg tatggggccg gatggccttc 34860 gtcatgatgg cgctgatggc ctcgctcgcc acggcgctcg tctacggcgt cggtggcggg 34920 ctcgtgctcg ccggggcatt ccaggtcggc acgctggtcg ccatcgccac cctgctcggg 34980 cggctgttcg ggccgatcac ccagctgtcc gggatgcagg agctcttcca gaccgtcgtg 35040 gtgagcttct cccgggtctt cgagctgctg gacctgaagc cgttgatcca ggaacgcccc 35100 gacgcggtca agctcgacaa ggacgtggcc ccggacatcg agttcgagaa cgtgtcgttc 35160 cgctatccca ccgcggacga ggtctcgctg gcgtcgctgg agcacctgaa ggccaagcgg 35220 gaacgcgggg aagtgacacc ggatgtcctg cgcgacgtga gcttccacgt gcaggccgga 35280 acgctcaccg cgctcgtcgg cccctccggc gcgggcaaga gcaccatcac ccacctggtc 35340 tcccggctgt acgacccgaa ctccgggacc gttcgcgtcg gcggacacga tctgcgggac 35400 ctcaccttcg actcgatccg cgaagcggtg ggtgtggtca gccaggacgc ctacctcttc 35460 cacgacacga tccgggagaa cctgctctac gcccgcccga cggccaccga ggacgagctg 35520 atcgaggcgt gcaagggggc ccagatctgg gatctgatcg aatcccttcc cctcgggttg 35580 gacaccgtca cgggtgaccg cggctaccgc atgtccggcg gggagaagca gcggctggcc 35640 atcgcccggc tgctgttgaa ggagccgagg atcgtcgtgc tcgacgaagc caccgcgcac 35700 ctggactccg agtcggaggc cgccgtccag cgggcactca agaccgcgct gcgcagccgt 35760 acctcgctgg tgatcgctca ccggttgtcc acgatccgcg aagccgacca gatcctcgtg 35820 atcgacggcg gcggggtccg tgagcgtggc acccacgacg agttgatggc caagggcggt 35880 ctctacgcgg agctctacca cacacagttc gccgacccac gaatcaatga agccaagccg 35940 gaacgcgaag acgagctgga cgagccggag ccagagccgg tggcttacat gggttttgga 36000 ggatgacgat gacttccgca gcgcgtaccg cgccgacggt gctggatctg ttcgcccggc 36060 acgtggaccg gacgcccgat gcggtggccg tggccgacgg cgatcgggtt ctgacgtatc 36120 gggaactcga tgagctctcg ggccggttgt ccggacggtt gatcagccgg ggcgtccgcg 36180 gtggcgaccg cgtcgcggtc atgatggacc gttcggctga cctggtggtc gcgctgctcg 36240 gcgtgtggaa gtcgggcgcg gcgtacgtgc cggtggacgc cgcctacccc gcgccgcggg 36300 tcgcgttcat ggtggcggac tcggcggtgt ccctgacggt gtgctcggcc gcgacccgcg 36360 acggcgtacc ggagggaatc gagtcgatcg tcatcacgga cgaagacgcg agcgacacgt 36420 cggtggccac ggtgcgccca ggggacctgg cgtacgtgat gtacacgtcc ggctcaacgg 36480 gcacgccgaa gggcgtggcg attacgcacg gcaccattgc ggaattggct gaggatcccg 36540 gttgggtgat ggagcccggc gaagcggtgc tgatgcattc gccgcacacc ttcgatgcgt 36600 ccctgttcga ggtctggacg ccgctgtcgt tgggcgctcg ggtggtgatc gccgagccgg 36660 gttcggtgga cgtccggcgc ctgcgcgagg cggccgcggc cggcgtgacg agggtgtacc 36720 tgaccgcggg gagcttccgc gcggtggccg aggaatcgcc ggagtcattc gcggctttcc 36780 gtgaggtgct gaccggcggt gacgtggtgc ccgcgcacgc ggtggagcga gtgcgggagg 36840 cctgccccgg ggcgcgggtt cggaacatgt acggcccgac ggaagcgacg atgtgcgcga 36900 cgtggcatct gctgcagccg ggtgacgtga tgggtccggt catgccgatc ggacgtccgc 36960 tggcgggccg ccggattcag gtgctcgacg agtcgctgcg gccggtggag ccgggtgtgg 37020 tcggtgacct gtacctgtcc ggtggtctgg cggagggcta cttcaaccgg gcgggcctga 37080 ccgcggaacg gttcgtggcg gatccatccg cacccgggca gcggatgtac tggacggggg 37140 acctggccca gtggaccgcg gacggtgagc tgctgttcgc gggccgggcc gaccaccagg 37200 tgaaggtccg cgggttccgg atcgagcccg gcgagatcga ggccgcgctg atcgcgctgc 37260 cggacgtgca ggacgccgtg gtggcggcga tcgatggacg gctggtcggt tatgtggtgg 37320 cggacgggga tgtggatccc gctctcatcc gcgagcgcct cggggcgcaa ctgccggagt 37380 acatggttcc ggcggctgtg atcgcactgg acgcgttgcc gctgaccgcc aacggcaagg 37440 tggacagggc ggcgctgccc gcccctgagt tcgcggcgaa cgccacgagc cgggcaccca 37500 gcaccgacgc ggaacgtgtc ctctgtggac tgttcgccga gttgctcggt attgaccgag 37560 ccggtgtgga cgacggcttc ttcgagctgg gcggcgattc gatcgtcgcg atgcgtcttg 37620 cggcacgtgc ggccaaggcc gggttgctgg tgacgcccgt ccagatcttc gacgagaaga 37680 cccccgcgcg gctggcggcc gtggcgcgtg cggtaccggc cgacaggccc gacgacgccc 37740 ccttgatcgc actgaccgcg gcggaggagg ccgagctggc gatcgccgcc ccgggcgccg 37800 acgagatctg gccgctggca ccgctgcagg acgggttgct cttcgagtcg accctcgatg 37860 atcaagggcc cgacatctac caggtgcagg tgatcctgga gctgaccggg ccgctggacg 37920 aggcccggct gcgggccgcg tgggacacgg tcctgcgccg gcacgccgag cttcggctga 37980 gcttccatcg actcgcgtcg ggcaagacgg tgcaggccgt ccacggggac gtcaccctgc 38040 catggcggtc ggtggatctg tcaggtgccg acgatgtcga cgcggccgtc gaggcactgg 38100 tcggactgga acagcaggag cggttcgatc tcgccacggc gccgcttgtc cggctggtgc 38160 tggtgcggat cgcggaggac cggcaccggc tgctggtcgt cattcaccac atcctgatcg 38220 acgggtggtc ggtggcggtc attctcaacg aggtgtccga ggcgtacacg gccggtgagc 38280 agttcccgca acagcggggt ggcgcctcct tccgggacta cttggcttgg ctcaaccggc 38340 aggacaagga cgcggcacgg gcggcatggc gggcggagct gtccggcctc gacgagcccg 38400 cgctgatcgc gccggcgggc accgcgacgg actacgacta ccgcgccacc cacctgtcgc 38460 cggttctgca caccaggctg ctggagttcg cccgtgagca ggggctgacg gtgagcacgg 38520 tggtgcacgg tgcctgggcg atggtgctgg cgaggcttgc ccggcgaacc gacgtggtgt 38580 tcggcaccat ggtcgcgacc cgtcccgcgg aactccaggg cgtggagtcg atgccgggcc 38640 tgctgatgag cgcggtgccg gtccgagtga cactggacgg cgggcagtcg gtcgtggaca 38700 tgctcaccga tctgcacaac cggcagacgg ccctcatgcc gcaccagcat ctgggactac 38760 cggagatcca gaaggcggcc gggcctggcg cgacgttcga cacgatgctg gtgatcgaga 38820 actacccgcg caactacgcc ggtcagtaca cgtatctgcg cacgatcgag gggacccact 38880 atccggtgac cctcggcatc accccggcgg atcggttcaa gatccagctc ggctactggc 38940 cggggcagat cccggacgcc atcgccgagt cgctgctgga gtggttcgtc ggcgccatcg 39000 gcgcgctggt cgccgatccg tccggcctgg tggggcgggt cggtatgggc acggccgcgg 39060 cacgcggctg ggccccgcca ttggtggcgg ggcagccgct tcccgcgctg gtaggacaga 39120 tggcggcgca gcggcccaac gacgtggcgt tggtggatcg cgatggtgag ttgtcgtatg 39180 gggagctgtg ggaacggtcg gtgaagttcg cggccgtgtt gcgggcccac ggggttggct 39240 ccgagagccg ggtcggcctg gtggtggggc ggtcggcctg gtggacggtc ggcatgttgg 39300 gcgtaatgtt ggcgggcggc acgttcgtgc cggtcgaccc ggcatatccg gacgagcgca 39360 aggaatggat tttccgaagc gcggatccga tgttggtggt gtgcgggggt acgacgcgcg 39420 agacggtgcc cgcgcagttc gcggaccggt tgttggtgat cgatgaggtg gacctggcag 39480 cgggctcgga tgctgcgctg ccacaagtgg atccgcgtaa tgccgcgtat gtgatctaca 39540 cgtcggggtc gacgggaact ccgaagggag tcgtcgtcac ccatgcgggg cttgggaacc 39600 tggcgttggc gcacatcgac cggttcgctg tggccccgtc gtcccgggtt ctgcagttcg 39660 cggcgctcgg cttcgacacc atcgtgtccg aggtgatgat ggcgttgctg tcgggagcga 39720 cgctggtggt gccgccggag caggatttgc cgccgaaggc gacgctgacc gagaccttgg 39780 agcggtggga cgtcacgcac gtgaaggccc cgccgtcggt gctgggcacc gtcgacgcgt 39840 tgcccgacag ggtggagacg gtggtggcgg cgggagagct ctgcccgccg ggcctggtgg 39900 accgcctgtc ggcggaccag cggatgatca acgcctacgg gccgaccgag accacgatct 39960 gtgcgacggt gagcatgccg ttgtcgccgg gccagcatcc gatcccgttc ggcgggccgg 40020 tcccgggcgt tcgcggttat ctgctggact cgttcctgcg tccgttgccg cccggcgtca 40080 ccggtgagct gtatctggcc gggatcgggg tggcccgcgg ctatctgggc cgttcggcgc 40140 tgacagccga gcggttcgtc gccgatccgt tcgtccccgg tgagcggatg taccggaccg 40200 gtgacctggc gtactggacc gaccagggtg agctggtgtc cgccgggcgc gccgacgacc 40260 aggtcaagat ccgtggattc cgggtcgaac cccgcgagat cgagttcgcc ctgtccggct 40320 acccgcggat cacccaagcc gcggtgaccg tccgcgacga ccgcctggtg gcctacgtga 40380 caccaggcga catcgacacc caagcggtgc gggacgatct cgcgtcccgg atgccccagt 40440 acatggtgcc cgcggcggtg gtggcgctgg acgccctgcc gctgacggcg cacgggaaga 40500 tcgatcgacg cgcgctgcct gaccccgatt tcaccgccgg gaccacctcc agggagccga 40560 ccaccgagac cgagcgggtg ttgtgcgagt tgttcgccgg cgtgctcggt ctggcacggg 40620 tcggcgtgga cgacagtttc ttcgagctgg gcggggactc catcctctcg atgcagctgg 40680 ctgcgcgggc gcggcgggca ggactgacgt tcaccgcggc ggacgtcttc gacgggaaga 40740 cgcccgagcg gatcgcgcac ctggcagcgg tggaatcggc gccgtcggag catggtcgtt 40800 ccacgacggc tgatggtgtc ggtgatgtcg cgtggacgcc gttgacgtgg atgttgggcg 40860 acggcgttgt gggagccagg ttcgcgcagt ggatggtcgt gggtgcgcct tcggatttga 40920 cggagaaggc gttggtcgcg gggtttgcgg ccctggtgga tacgcatgac atgttgcggg 40980 cgcgtgtcgt caacgatcag ggcggccggc gcttggtggt gggtgagcgt gggtctgtgg 41040 atgcggccaa gttggtcacc cgcgtgcggg ttgacggtgg ctcgttggac gaggctgtgg 41100 aggacgcggc gcgagaggcc gtgaaccggt tggacccgct ggcgggcgtg atggcccagg 41160 cggtgtgggt ggacgccgga ccggatcagg tgggccggtt gctggtggtg gcgcatcact 41220 tgtcggtcga cggcgtgtcg tggcgggttt tgatgtcgga tctccaggcg gccaccgaag 41280 cggtggcggc ggggcgggat ccggtgctgg agccggaggg cgtgtcgttc aggcggtggg 41340 cgggcctgct gaaggagtgg gcggtcgccg cggaccgggt cggcgagttg gcggcgtgga 41400 aggcgattct cggtcacgag gagcagccag tcggtgcacg tgggctgacc acaggccagg 41460 ccgcgcaagg cgatgtgcgc tcacgctcgt gggtggtgcc gaaggccgag acgtcggtgt 41520 tgatggggcg ggctccggtg gtgttccact gcggggtgaa cgaggttctg ctcgccgggc 41580 tggccggagc ggtggcccgg tggcgcggcg gcgacgcggt gttggtggac gtggaaagcc 41640 acggccgtca tccggtcgac gggatggacc tgtcccggac cgttggctgg ttcaccagcg 41700 cacatccggt acggctcgac gtggcgggga tcgacttggc ggacgtgctc gccggtggtt 41760 cggcggccgg gcggttgctg aaggtggtca aggaacagtc gcgggccgtg cccggcgacg 41820 ggctcggata tggactgttg cgttatctca acggcacgac cgggccggtt ctggctgaac 41880 tgccgtcgcc gcagatcggg ttcaactaca tgggccggtt cgtcaccagt gagaagagtg 41940 gtgtgcgggc gtggcagccg gtcggtgaca tcggtagctc gctggaaccc ggcatgggcc 42000 tgccgcacgc gctcgacgtc aacgcgctcg tccaggattt gccggacggc cctgaactga 42060 cgctcatggt cgagtggcag gaggacctgc tcggcgaggc cgagatcgaa cgactggtcc 42120 aggaatggct ggacatgttg tccgggctgg cccgtcaggc ggacgatccc gccgcgggcg 42180 gacacaccgc gtccgacttc gatctcgtcg accttgacca ggacgagatc gaggctctcg 42240 aggccgaaca cgcgggtgtc ggtgggctgg ccgatgtgtt gccgttgtcg ccgctgcagc 42300 acgggctggc gttccacgcc ggctacgcgg gtggcgtcga tgtctacacc gcacaggcgg 42360 tgctggatc 42369 // ![]() |