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EBI DbfetchID AJ426044; SV 2; linear; genomic DNA; STD; PRO; 11821 BP. XX AC AJ426044; XX DT 26-JUL-2002 (Rel. 72, Created) DT 15-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Escherichia coli waa gene cluster encoding the LPS R1 core biosynthesis DE region XX KW beta 1,3-glucosyltransferase; heptosyl-I-kinase; heptosyl-I-transferase; KW heptosyl-II-kinase; heptosyl-III-transferase; KDO transferase; KW lipid A-core surface polymer ligase; KW UDP-galactose:(galactosyl)LPS alpha-1,2-galactosyltransferase; KW UDP-galactose:(glucosyl)LPS alpha-1,2-galactosyltransferase; KW UDP-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase; KW UDP-glucose:(heptosyl)LPS alpha-1,3-glucosyltransferase; waaA gene; KW waaC gene; waaG gene; waaL gene; waaO gene; waaP gene; waaQ gene; KW waaT gene; waaV gene; waaW gene; waaY gene. XX OS Escherichia coli OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. XX RN [1] RC revised by author [14-MAR-2002] and [12-JUL-2002] RA Dobrindt U.; RT ; RL Submitted (18-DEC-2001) to the EMBL/GenBank/DDBJ databases. RL Dobrindt U., Inst. f. Molekulare Infektionsbiologie, Universitaet RL Wuerzburg, Roentgenring 11, 97070 Wuerzburg, GERMANY. XX RN [2] RX DOI; 10.1128/JB.184.21.5912-5925.2002 RX PUBMED; 12374825. RA Grozdanov L., Zahringer U., Blum-Oehler G., Brade L., Henne A., RA Knirel Y.A., Schombel U., Schulze J., Sonnenborn U., Gottschalk G., RA Hacker J., Rietschel E.T., Dobrindt U.; RT "A single nucleotide exchange in the wzy gene is responsible for the RT semirough O6 lipopolysaccharide phenotype and serum sensitivity of RT Escherichia coli strain Nissle 1917"; RL J. Bacteriol. 184(21):5912-5925(2002). XX FH Key Location/Qualifiers FH FT source 1..11821 FT /organism="Escherichia coli" FT /strain="DSM 6601" FT /mol_type="genomic DNA" FT /isolation_source="faecal" FT /serovar="O6:K5:H1" FT /db_xref="taxon:562" FT CDS complement(1..1278) FT /transl_table=11 FT /gene="waaA" FT /product="KDO transferase" FT /db_xref="GOA:Q7AUZ4" FT /db_xref="InterPro:IPR007507" FT /db_xref="UniProtKB/TrEMBL:Q7AUZ4" FT /protein_id="CAD19780.2" FT /translation="MLELLYTALLYLIQPLIWIRLWVRGRKAPAYRKRWGERYGFYRHP FT LKPGGIMLHSVSVGETLAAIPLVRALRHRYPDLPITVTTMTPTGSERVQSAFGKDVQHV FT YLPYDLPDALNRFLNKVDPKLVLIMETELWPNLIAALHKRKIPLVIANARLSARSAAGY FT AKLGKFVRRLLRRITLIAAQNEEDGARFVALGAKNNQVTVTGSLKFDISVTPQLAAKAV FT TLRRQWAPHRPVWIATSTHEGEESVVIAAHQALLQQFPNLLLILVPRHPERFPDAINLV FT RQAGLSYITRSSGEVPSTSTQVVVGDTMGELMLLYGIADLAFVGGSLVERGGHNPLEAA FT AHAIPVLMGPHTFNFKDICARLEQASGLITVTDATTLAKEVSSLLTDADYRSFYGRHAV FT EVLYQNQGALQRLLQLLEPYLPPKTH" FT CDS 1727..2749 FT /transl_table=11 FT /gene="waaQ" FT /product="heptosyl-III-transferase" FT /db_xref="GOA:Q8KMX2" FT /db_xref="InterPro:IPR011916" FT /db_xref="UniProtKB/TrEMBL:Q8KMX2" FT /protein_id="CAD19781.1" FT /translation="MRFHGDMLLTTPVISSLKKNYPDAKIDVLLYQDTIPILSENPEIN FT ALYGIKNKKAKASEKIANFFYLIKVLRANKYDLIVNLTDQWMVAILVRLLNARVKISQD FT YHHRQSAFWRNSFTHLVPLQGGNVVESNLSVLTPLGLESLVKQTTMSYPPASWKRMRRE FT LDHAGVGQNYVVIQPTARQIFKCWDNAKFSAVIDALHARGYEVVLTSGPDKDDLACVNE FT IAQGCQTPPVTALAGKVTFPELGALIDHAQLFIGVDSAPAHIAAAVNTPLISLFGATDH FT IFWRPWSNNMIQFWAGDYREMPTRDQRDRNEMYLSVIPAADVIAAVDKLLPSSTTGTSL FT " FT CDS 2746..3870 FT /transl_table=11 FT /gene="waaG" FT /product="UDP-glucose:(heptosyl)LPS FT alpha-1,3-glucosyltransferase" FT /db_xref="GOA:Q8KMX1" FT /db_xref="InterPro:IPR001296" FT /db_xref="UniProtKB/TrEMBL:Q8KMX1" FT /protein_id="CAD19782.1" FT /translation="MIVAFCLYKYFPFGGLQRDFMRIAQTVAARGHHVRVYTQSWEGEC FT PDVFELIKVPVKSHTNHGRNAEYFAWVQKHLREHPVDRVVGFNKMPGLDVYYAADVCYA FT EKVAQEKGFFYRLTSRYRHYAAFERATFEQGKPTQLLMLTDKQIADFQKHYQTEAERFH FT ILPPGIYPDRKYSQQPANSREIFRKKNGITEQQYLLLQVGSDFTRKGVDRSIEALASLP FT DSLRHNTLLYVVGQDKPRKFEALAEKRGVRSNVHFFSGRNDVSELMAAADLLLHPAYQE FT AAGIVLLEAITAGLPVLTTAVCGYAHYIVDANCGEAIAEPFRQETLNEILRKALTQSSL FT RQAWAENARHYADTQDLYSLPEKAADIITGGLDG" FT CDS 3863..4660 FT /transl_table=11 FT /gene="waaP" FT /product="heptosyl-I-kinase" FT /function="unknown" FT /db_xref="GOA:Q8KMX0" FT /db_xref="InterPro:IPR017172" FT /db_xref="UniProtKB/TrEMBL:Q8KMX0" FT /protein_id="CAD19783.1" FT /translation="MVELKEPFATLWRGKDPFEEVKTLQGEVFRELETRRTLRFEMAGK FT SYFLKWHRGTTLKEIIKNLLSLRMPVLGADREWNAIHRLRDVGVDTMYGVAFGEKGINP FT LTRTSFIITEDLTPTISLEDYCADWATNPPDVRVKRMLIKRVATMVRDMHAAGINHRDC FT YICHFLLHLPFSGKEEELKISVIDLHRAQLRTRVPRRWRDKDLIGLYFSSMNIGLTQRD FT IWRFMKVYFSAPLKDILKQEQGLLSQAEAKATKIRERTIRKSL" FT CDS 4676..5692 FT /transl_table=11 FT /gene="waaO" FT /product="UDP-glucose:(glucosyl)LPS FT alpha-1,3-glucosyltransferase" FT /db_xref="GOA:Q8KMW9" FT /db_xref="InterPro:IPR002495" FT /db_xref="UniProtKB/TrEMBL:Q8KMW9" FT /protein_id="CAD19784.1" FT /translation="MSAHYFNPQEMINKTIIFDERPAVSVASSFHVAYGIDQNFLFGCG FT VSITSVLLHNNDVSFVFHVFIDDIPEADIQRLSQLAKSYHTCIQIHLVNCERLKALPTT FT KNWSIAMYFRFVIADYFIDQQDKILYLDADIACQGNLKPLITMDLANNVAAVVTERDAN FT WWSLRAQSLQCNELEKGYFNSGVLLINTLAWAQESVSAKAMSMLADKAVVSRLTYMDQD FT ILNLILLGKVKFIDAKYNTQFSLNYELKKSFICPINDETVLIHYVGPTKPWHYWAGYPS FT AQPFIKGKEASPWKNEPLMRPMNSNYARYCAKHNFKQNKPINGIMNYIYYFYLKIIK" FT CDS 5709..6704 FT /transl_table=11 FT /gene="waaT" FT /product="UDP-galactose:(glucosyl)LPS FT alpha-1,2-galactosyltransferase" FT /db_xref="GOA:Q8KMW8" FT /db_xref="InterPro:IPR002495" FT /db_xref="UniProtKB/TrEMBL:Q8KMW8" FT /protein_id="CAD19785.1" FT /translation="MNEFIKERFSYLADNKKENVPELNVSYGIDKNFLYGAGVSISSVL FT INNSDINFVFHVFTDYVDDDYLKSFNETAKQFNTSIIVYLIDPKYFADLPTSQFWSYAT FT YFRVLSFEYLSESISTLLYLDADVVCKGSLKPLTKIIFKDEFAAVIPDNDSTQAACAKR FT LNIPGMNGRYFNAGVIYVNLKKWHEANLTPYLLTLLRGETKYGSLKYLDQDALNIAFNM FT NNIYLAKDFDTIYTLKNELHDRSHRKYQQTITDKTVLIHYTGITKPWHSWAGYPSASYF FT NIAREQSPWKKYPLKEARTVAEMQKQYKHLFAHGEYIKGITSLIKYKLKK" FT CDS 6714..7406 FT /transl_table=11 FT /gene="waaY" FT /product="heptosyl-II-kinase" FT /db_xref="GOA:Q8KMW7" FT /db_xref="InterPro:IPR009330" FT /db_xref="UniProtKB/TrEMBL:Q8KMW7" FT /protein_id="CAD19786.1" FT /translation="MITSIRYRGFSFYYKDNDNKYKEIFDEILAYNFKTVKVLRNIDDT FT KVSLIDTKYGRYVFKVFAPKTKRNERFLKSFVKGDYYQNLIVETDRVRSAGLTFPNDFY FT FLAERKIFNYASVFIMLIEYVEGVELNDMPIIPEDVKAEIKASMEKLHALNMLSGDPHR FT GNFIVSKDGVRIIDLSGKSCTAERKARDRLAMERHLGIANEIKDYGYYSVIYRTKLRKF FT IKKLKGKA" FT CDS 7432..8460 FT /transl_table=11 FT /gene="waaW" FT /product="UDP-galactose:(galactosyl)LPS FT alpha-1,2-galactosyltransferase" FT /db_xref="GOA:Q8KMW6" FT /db_xref="InterPro:IPR002495" FT /db_xref="UniProtKB/TrEMBL:Q8KMW6" FT /protein_id="CAD19787.1" FT /translation="MDLLAESITEVAVSGEIANTDRVLNIAYGIDRNFLFGAAVSMQSV FT VMHNPDLAVKFHLFTDYIDEDYLQRVNAFTSKNANVEVRIYKVSSAFIDIFPSLKQWSY FT ATFFRLVAFQYLSETIENLLYIDADVICKGSLAGLLDINFDGDKFAAVIKDVPFMQEKP FT AKRLAIEGLPGNYFNAGVVYLQLEAWAKNDFMNKAIAMLASDPQHTKYKCLDQDILNIL FT FFSHCIFISGDYDCFYGIDYELKNKSDEDYKKTITDDTKLIHYVGVTKPWNDWTNYPCQ FT KYFNEAYQVSCWNDVAFIPATNEKQYQVKYQHAKKNGDTFNAFIYFIKFKLNKYKRKLF FT GQ" FT CDS 8542..9525 FT /transl_table=11 FT /gene="waaV" FT /product="beta-1,3-glucosyltransferase" FT /db_xref="GOA:Q8KMW5" FT /db_xref="HSSP:1QGQ" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q8KMW5" FT /protein_id="CAD19788.1" FT /translation="MSNDYPLVSIIIPTYNSSDYITETLTKLEKQTYPNFEIVIVNDGS FT KDNTSSVLREYGLTHSRLIIINKENGGVSSARNTGIRKAQGQFICFMDDDDEIDPNYLL FT KMYSRQHETGGDAIYCGLYGHHIKNGVTYSPINTDFNEGSLLFDFFYKKVRFHIGCLFI FT RKQLLEDNNLFFDEDLRLGEDLDFIYRLLITCDMYAVPYYMYKHNYRENSLMNSCRTIT FT HYRHESFAHERIYSSVMQLYKGNRKEEIHTLLSKNRTYHKTRYLWNVLLNGDFELLNQL FT VESNEKELKDCNLLGKRDKRRAKILASKNYILWRMVRLVNRKKNKR" FT CDS 9571..10824 FT /transl_table=11 FT /gene="waaL" FT /product="putative lipid A-core surface polymer ligase" FT /db_xref="GOA:Q8KMW4" FT /db_xref="InterPro:IPR007016" FT /db_xref="UniProtKB/TrEMBL:Q8KMW4" FT /protein_id="CAD19789.1" FT /translation="MSFCWNEINSGVKSLILILCMLSLMTLSLWDDVATKFLHAAGIIS FT ALYFLATPKKTITNNPTLLIFISLCLLGIVNIIWYSHYKVSGSVYTNAYRGPMETGKIA FT LCSAFIFLVLFAKDEMRTKIKFGKLILFASLATQLLFFAHAMWQHFYLNVDRVALSASH FT ATTAGYIILFPSLLASILILKSDFRHKTTLYTINFMLSLCAVIVTETRAAILVFPFFAL FT LLIVMDSYINKRINYKLYCFIAIALLAGVFSFKDTLLTRMNDLNRDLVNYSHDNTRTSV FT GARLAMYEVGLKTYSPIGQSLEKRAEKIHELEEKEPRLSGALPFVDSHLHNDLIDTLST FT RGIPGVALTILAFSAIFIYALRTAKEPYILILLFSLLVVGLSDVILFSKPVPTAVFVTI FT ILLCAYFKVQSDQCLLDK" FT CDS complement(10894..>11821) FT /codon_start=2 FT /transl_table=11 FT /gene="waaC" FT /product="heptosyl-I-transferase" FT /db_xref="GOA:Q8KMW3" FT /db_xref="InterPro:IPR002201" FT /db_xref="UniProtKB/TrEMBL:Q8KMW3" FT /protein_id="CAD19790.2" FT /translation="PALTDAQQAIPGIKFDWVVEEGFAQIPSWHAAVERVIPVAIRRWR FT KAWFSAPIKAERKAFREALQAKNYDAVIDAQGLVKSAALVTRLAHGVKHGMDWQTAREP FT LASLFYNRKHHIAKQQHAVERTRELFAKSLGYSKPQTQGDYAIAQHFLTNLPTDAGEYA FT VFLHATTRDDKHWPEEHWRELIGLLADSGIRIKLPWGAPHEEERAKRLAEGFAYVEVLP FT KMSLEGVARVLAGAKFVVSVDTGLSHLTAALDRPNITVYGPTDPGLIGGYGKNQMVCRA FT PGNELSQLTANAVKQFIEENAEKAAMI" XX SQ Sequence 11821 BP; 3414 A; 2363 C; 2558 G; 3486 T; 0 other; tcaatgcgtt ttcggtggca ggtaaggttc cagcagttga agcagacgct gtagtgcgcc 60 ctggttttga tacagcactt caacggcatg acggccatag aaactacggt aatcggcgtc 120 ggtgagtaaa gaggaaacct cttttgcaag cgtagtggca tcggtaacgg taatcagccc 180 gcttgcctgc tccagccgcg cgcaaatgtc tttaaagtta aacgtatgcg gccccatcaa 240 taccggaata gcgtgtgcgg ccgcttccag cggattatgc ccaccacgtt caaccagtga 300 accgccaaca aaggcgagat cggcaatgcc gtacagtaac atcaactcgc ccatcgtatc 360 gccaaccaca acctgcgtgc tggtggaggg gacttcccct gaagatcgtg tgatatagct 420 tagtccagcc tggcggacaa ggttaatcgc atccgggaag cgttctggat gacggggtac 480 caggatgagc aataaattcg ggaattgctg taacaatgcc tgatgtgcgg cgatcaccac 540 actctcttcg ccttcatgag tgctggtggc aatccatacc gggcggtgtg gtgcccattg 600 gcggcgcagc gtcacggctt tagcagccaa ctgcggcgtt acagaaatat cgaatttcag 660 gctaccggta acggtcacct gattattttt tgcgcccaac gccacaaaac gagcaccatc 720 ttcttcattt tgggcggcaa tcagcgtaat acgacgcagc aagcgacgga cgaatttacc 780 cagtttggca taacctgcgg ccgagcgggc agagagtcgc gcgttagcga tcaccagcgg 840 aattttacgt ttatgtagcg ccgcaatcag gttaggccat agttcggttt ccataatcaa 900 caccagttta gggtcgactt tattcaggaa acggttgagt gcatcgggca ggtcatacgg 960 cagataaacg tgctgaacat ccttcccgaa agccgattgt acgcgctccg aaccggttgg 1020 agtcatggtt gttacggtaa tcggtaaatc aggataacga tgacgcagtg cgcgcaccaa 1080 cgggatcgcc gccagagttt caccgacgga gacggagtgc agcataatgc cgcctggttt 1140 tagcggatgg cggtaaaaac cgtaacgttc accccagcgt tttcgatagg ccggagcctt 1200 acgtccgcgc acccagagcc gtatccagat cagcggctga ataaggtaga gaagggcggt 1260 gtaaagcaat tcgagcatag taaatagctg acttatggat gtgctgggga ttctatgtat 1320 ttagctgtgg ctttaccatt acttttccca tttttgactt aaatagcaat ttacccgcca 1380 attcttgctg aacatctata ctttttttgt atttttatgc gattcattga tttctgcagt 1440 acgtgcagga aggaatcgca gagcaacagt aaaagaatat ggttgctaat gattttattt 1500 gattgatttc tttattgaaa atcaacaatg tgcttaaaaa tcattcgagt cggattgccg 1560 cgaaagaagt gatacactag cgcgtcaata tcagtgcggt atcagtattc aggtagctgt 1620 tgagcctggg gcggtagcgt gctttttctg cttcacctta atcggataat ctcaacaaaa 1680 agagttactt gtggataagc catttcgaag aattttgctc attaagatgc gttttcatgg 1740 ggatatgtta ttaactactc ccgtcattag ttcgctgaaa aaaaattacc ctgacgcaaa 1800 aatcgatgtg ctgctttatc aggacaccat cccgatcctg tctgaaaatc cagagattaa 1860 cgcgctctac ggcataaaaa ataaaaaagc aaaagcctca gaaaaaattg ccaacttttt 1920 ttatctcatc aaggtattac gtgccaataa gtatgacctt atcgttaatc ttaccgatca 1980 atggatggtt gctatactgg ttcgcttatt aaatgcccgt gtgaaaattt cccaggatta 2040 tcatcatcgg cagtctgctt tttggcgtaa tagtttcact catttggtgc cgttgcaggg 2100 tggaaatgtg gtggaaagta acttatccgt gctgacgcca ttgggacttg aatcgttggt 2160 gaagcagaca accatgagtt acccgcctgc aagctggaaa cgtatgcgtc gcgaacttga 2220 tcacgctggt gttggacaaa attatgtggt tatccaacct acggcgcggc aaatcttcaa 2280 atgttgggac aacgccaagt tttccgctgt gattgatgcc ttacatgctc gtggttatga 2340 agtcgttctg acgtccggcc cagataaaga cgatctggcc tgcgtcaatg aaattgcgca 2400 gggatgccag acgccaccag taacggcgct ggccggaaag gtgaccttcc cggaacttgg 2460 tgcgttaatc gatcatgcgc agctgtttat tggcgttgat tccgcaccgg cgcatattgc 2520 cgctgcagtt aatacgccgc tgatatcgct gtttggtgcg acagaccata ttttctggcg 2580 tccctggtca aataacatga ttcaattctg ggcgggagat taccgggaaa tgccaacgcg 2640 cgatcagcgt gaccgaaatg agatgtatct ttcggttatt ccggcggcag atgtcattgc 2700 agctgtcgat aaattacttc cctcctccac gacaggtacg tcgttatgat cgttgctttt 2760 tgtttatata aatattttcc ctttggcggt ttgcagcgcg attttatgcg tattgctcag 2820 acagttgccg cccgaggtca tcatgttcgg gtttataccc agtcgtggga aggcgaatgc 2880 cctgatgtat ttgaactgat caaagtgccg gttaaatcgc ataccaatca cgggcgcaat 2940 gcggaatatt ttgcctgggt gcaaaaacat ttacgtgaac accccgtcga tagagtcgtt 3000 ggatttaata aaatgccggg gctggacgtt tattatgccg ctgatgtttg ttatgccgag 3060 aaagtagcgc aggagaaagg ctttttctat cgcctgacgt cacgttatcg ccattatgcc 3120 gcctttgagc gggcaacctt cgaacagggc aagccgacac agctgctgat gctgacagat 3180 aagcaaatcg ccgatttcca gaaacattat cagactgaag cggagcgttt tcatattctg 3240 cctccgggga tttatcctga tcgtaaatat agccagcagc cagccaatag ccgtgaaatc 3300 ttccgtaaga agaatggaat aaccgaacaa caatatttat tgttgcaggt tggttcagac 3360 ttcacgcgta aaggtgtcga tcgttccatt gaagcacttg cttcgttacc ggattcgctg 3420 cgccacaaca cattactata tgttgttggg caggataaac cgcgaaaatt tgaggcgctg 3480 gcagaaaaac gcggcgtgcg cagtaatgtt cacttcttct cggggcgcaa cgatgtctcg 3540 gaattaatgg cggcggcgga tttattactt catcctgcct accaggaagc cgcgggaatt 3600 gtactgctgg aagcgataac tgcaggatta ccggtactaa caacagccgt ttgtggctat 3660 gcgcattata ttgtcgacgc caattgcggc gaggctattg ctgagccatt ccgccaggaa 3720 acattgaatg agattttacg caaagcgtta acgcaatctt cattgcgcca ggcctgggcg 3780 gaaaatgcgc gacattatgc tgatacacaa gatttataca gtctgccaga gaaagcggcg 3840 gacatcataa cgggtggtct ggatggttga acttaaagag ccgtttgcca cgttatggcg 3900 cggtaaagat ccttttgagg aagttaaaac cttgcagggt gaggtatttc gtgaactgga 3960 aactcgccgc actctgcgct ttgaaatggc gggcaaaagc tattttctca aatggcatcg 4020 cggcacgacc ctgaaagaga taatcaaaaa tttactctca ttgcggatgc cagtattagg 4080 cgcagaccgc gaatggaatg cgattcatcg actgcgggat gtcggcgttg atactatgta 4140 tggggtggca ttcggcgaaa aaggcattaa tccgctgacc agaacctcgt ttattattac 4200 cgaagatctg acaccaacca tcagtctgga agattactgt gctgactggg cgaccaaccc 4260 accagatgtt cgcgtaaagc gtatgcttat taagcgtgtc gcgacgatgg tgcgcgatat 4320 gcatgctgcg ggcattaacc accgtgactg ttatatctgt catttcctgc tgcacttgcc 4380 tttttccggt aaggaagagg agttaaaaat ttcagtaatt gacctgcacc gggcgcagct 4440 tcgcacgcgc gttccacgtc gttggcgcga taaagatctt attggacttt atttttcttc 4500 gatgaatatt ggcctgactc aacgggatat ctggcggttc atgaaggtgt atttttctgc 4560 cccgcttaaa gacattctca agcaggaaca agggctgctg tcgcaagcag aagcaaaagc 4620 cacaaaaatc agggaaagaa cgattcgaaa atcgttgtaa tttccggaga gaaatatgag 4680 tgcccactat tttaatccac aagagatgat caataagaca atcatcttcg atgaaaggcc 4740 agcggtgtca gtggcatcat cattccatgt tgcttatggc attgatcaga actttctttt 4800 tggttgtggt gtttcaatca cgtcagtttt gttacataac aacgacgtga gttttgtttt 4860 ccacgttttt attgatgata tccctgaagc cgatatccag cgtttatccc aattagcgaa 4920 aagctatcat acctgtatcc agatccatct ggtgaattgt gaacggctta aggcattacc 4980 gacgaccaaa aattggtcta ttgccatgta tttccgtttt gtaattgcag attactttat 5040 tgatcaacaa gataagatcc tgtacctgga tgctgatatc gcctgtcagg gaaacttaaa 5100 gccgctgata acaatggatc ttgccaataa cgttgctgct gttgttactg aacgcgatgc 5160 taactggtgg tcattacgag ctcaaagtct gcagtgtaat gaacttgaaa agggttactt 5220 taattcaggt gtcctgttaa ttaatacact agcgtgggcg caggagtccg tttctgctaa 5280 agcgatgtcg atgcttgctg ataaagccgt cgtttcccgt ttaacctata tggatcaaga 5340 tatacttaat cttatcctgt tagggaaagt taaattcatt gatgctaaat acaatacgca 5400 atttagttta aattatgaat taaaaaaatc atttatttgt ccaattaatg atgaaaccgt 5460 attaattcat tatgtcggcc cgacaaaacc ctggcattac tgggccggtt atccaagcgc 5520 gcagccattt atcaaaggca aagaagcatc gccctggaaa aatgaaccgt taatgcggcc 5580 aatgaactca aattatgctc gttattgcgc taagcataat tttaaacaaa ataaaccaat 5640 taacgggata atgaattata tttattattt ttatttaaag ataataaaat gacattgaga 5700 aaagttaaat gaatgaattt ataaaagaac ggttttcgta tttagcagat aataaaaaag 5760 aaaacgtccc agagctaaat gtttcctacg gtatcgataa gaattttttg tatggtgctg 5820 gcgtttcaat ttcttccgtt ttgattaata attcagatat taattttgtc tttcatgttt 5880 tcactgatta tgtggatgat gattatttaa agtcatttaa tgaaacagca aaacaattta 5940 atacctcaat tattgtatat ttaattgacc caaaatactt tgctgatctg ccgacgtcac 6000 agttttggtc gtacgcgaca tacttcaggg tattgtcctt tgaatatctg agtgaaagta 6060 tttccacact gctgtatctg gatgccgatg tcgtttgtaa aggaagtctg aaacctctca 6120 caaaaattat atttaaagat gagtttgctg cggttattcc tgacaatgat agtactcagg 6180 cggcatgtgc aaaacgtctt aacattcccg gaatgaatgg acgttatttc aatgcaggcg 6240 ttatctatgt caatcttaaa aaatggcatg aagcaaattt gacaccgtat ttactcacgc 6300 ttttacgagg ggaaactaaa tatggctctc ttaaatattt agatcaggat gcgttgaata 6360 tcgcatttaa tatgaataat atctacctcg cgaaggattt tgatactatt tataccctga 6420 aaaacgaact tcatgatcgt agtcatcgaa agtatcagca aaccattacc gataaaacag 6480 tattgattca ctatacaggg ataactaaac catggcatag ctgggctgga tatccgtctg 6540 catcatactt taatatcgcg cgtgaacaat ctccctggaa gaaatatcct cttaaagagg 6600 cgcggactgt tgcagaaatg cagaaacaat ataagcatct gtttgcccat ggtgagtata 6660 ttaaaggtat aacttcatta attaagtaca agcttaagaa ataaattact cttatgatta 6720 caagtatacg ctatcgcggc ttctcatttt attacaaaga taacgataat aaatataaag 6780 aaatctttga tgaaatactg gcctataatt ttaaaacagt aaaagtatta cgtaatattg 6840 atgataccaa agtatcgttg attgatacga aatatggtcg ctatgttttt aaagtctttg 6900 ccccgaaaac gaaaaggaat gaacgttttt taaaatcttt tgtaaaaggt gactactatc 6960 agaatttgat cgttgaaacc gatcgtgtca gaagtgcagg tcttactttt cctaatgatt 7020 tttattttct ggctgagcgt aaaattttca actatgccag tgtttttatc atgcttatcg 7080 agtatgtcga gggcgtagag ctcaatgata tgccgattat tccagaagat gttaaagcag 7140 aaattaaggc ttcaatggaa aaattgcatg ccttaaatat gctatcgggc gacccacacc 7200 ggggtaactt tatcgttagt aaagatggtg tcaggataat tgacctatcc ggtaaaagct 7260 gtacggcaga gcggaaagcc cgtgatcgtc tggccatgga acgtcacctg ggtattgcca 7320 acgaaataaa agattatggc tactattcag taatctacag aaccaaacta cgcaaattta 7380 ttaaaaaatt aaaaggcaaa gcgtaaacca cacagtcaaa acggaaccaa catggattta 7440 ttagctgaga gtattactga agtcgctgtc tctggggaaa ttgctaacac cgatcgtgtg 7500 ttaaatatcg cttacggtat tgaccgcaac tttttatttg gtgcggcagt atctatgcaa 7560 tcagttgtta tgcataaccc ggaccttgcg gttaagtttc atctctttac tgactacatt 7620 gatgaagatt atctacaacg tgttaatgct tttaccagca aaaatgctaa cgttgaagta 7680 agaatttata aagtatccag tgcctttatt gatatcttcc ccagcctgaa acagtggtct 7740 tatgcaacat tcttccgttt agttgcgttc cagtatctga gtgaaactat tgaaaatctg 7800 ttatatatcg atgctgatgt catctgtaaa ggctcattag ctggattgct tgatattaat 7860 tttgatggcg ataagttcgc ggctgttatt aaagatgtgc cttttatgca ggaaaaacca 7920 gcgaagcgtc tggctataga gggacttcca gggaattatt tcaacgccgg tgtagtatat 7980 ctgcagcttg aagcatgggc gaaaaatgat tttatgaata aagccattgc tatgctggca 8040 agtgacccgc agcacacgaa atataaatgc cttgatcagg atattttaaa tattctgttc 8100 tttagtcatt gtatttttat tagcggcgat tatgattgct tttatggcat tgactatgag 8160 ttaaaaaata aaagcgatga agattataaa aagaccatta ccgatgatac taagctgatt 8220 cattatgttg gcgtaacgaa gccctggaac gactggacga attatccctg ccagaagtat 8280 tttaatgagg cttatcaggt ttcttgctgg aatgatgtgg cgtttattcc agccacgaat 8340 gaaaagcagt atcaagtgaa ataccaacat gcaaagaaaa atggtgatac gtttaacgct 8400 tttatttact tcattaaatt caaattaaat aagtataaaa gaaaactatt tgggcaataa 8460 taaaaatcat ggatgtctga gttacaataa taattaagga tgagtactat aatattttat 8520 tagttcaggc aagagaacac gatgagcaat gattaccctt tagtatccat aataataccg 8580 acgtataatt catctgatta cattactgaa actctaacga aattagaaaa acaaacttac 8640 ccaaattttg aaattgttat tgttaatgat ggttctaaag ataacacatc aagtgttttg 8700 agagagtatg ggttaaccca ctctcgatta attattatca ataaagaaaa tggcggtgtt 8760 tcgtctgcca ggaatacagg tatccgcaag gcgcaaggac agtttatatg ttttatggat 8820 gatgatgatg agatagatcc taactatctg ctgaagatgt attccagaca acatgagacg 8880 ggaggggatg cgatttattg tgggctttat ggccatcata taaaaaatgg tgttacttac 8940 tcacctataa atacagattt taatgaaggg tctttacttt tcgatttttt ttataaaaag 9000 gtcagattcc atataggatg cttgtttata agaaaacaac tcctagaaga taataatctt 9060 ttttttgatg aagatttacg actaggagaa gatctggatt ttatctatcg actgctaatt 9120 acatgcgata tgtatgcggt tccatattat atgtataagc ataactatag agaaaattcc 9180 ttaatgaact catgtagaac catcactcat tatcgacatg agtcatttgc gcacgaaaga 9240 atctactctt ctgtgatgca gttatacaaa ggtaaccgga aagaagaaat tcatacatta 9300 ttgagtaaaa atagaactta tcataaaact cgttatttat ggaatgttct acttaatggc 9360 gattttgaat tattaaatca attagttgaa agcaatgaaa aagaattgaa agattgtaat 9420 cttcttggca agagagataa gaggcgagca aagatattag catcaaaaaa ctatattctc 9480 tggaggatgg taagactggt aaatagaaaa aagaataaac gttaggtctt gcattaaata 9540 acccatcctc gtagcatagg ttgaaattat atgtcgtttt gttggaatga aattaactct 9600 ggtgtcaagt ctttaattct catattatgt atgttgtctt taatgacttt gtctttgtgg 9660 gatgatgttg caacaaagtt tcttcatgca gctggaatta tatctgcatt atattttcta 9720 gcgacaccaa aaaaaacaat aactaataat cctactttgt taattttcat ctcattatgt 9780 cttttgggta tcgttaatat catctggtat tcacattata aagtttcagg ctcggtttat 9840 accaatgcat atcgtggccc aatggaaact ggaaaaattg ccttgtgtag tgcttttatt 9900 ttcttagttc tttttgctaa agatgagatg agaaccaaaa taaaatttgg gaaactaatt 9960 ctgttcgcat ccttggcaac gcagttactt ttttttgcgc atgccatgtg gcaacatttc 10020 tatttaaacg tcgaccgtgt tgcattatca gcttcccacg ctacaacagc aggctacatc 10080 atccttttcc cttctttact ggcatcaatt ctcattttaa aatccgactt tagacataaa 10140 acaacattat atacaattaa cttcatgctt agcttatgtg ctgttatagt aactgaaacg 10200 cgtgcagcca tattagtgtt tccattcttt gcgttactat taatcgtaat ggatagttat 10260 attaataagc gaattaatta taagttatat tgttttattg cgattgcatt attagcaggt 10320 gtattttctt ttaaagatac attacttacg agaatgaatg acttaaatag ggatttagtt 10380 aattattcgc atgataacac cagaacttca gtcggtgccc gtctggcaat gtatgaagtt 10440 ggtttaaaaa catattctcc aataggacaa tcactggaaa aacgtgcgga aaaaatacat 10500 gaactagaag agaaagagcc tagattaagt ggtgctttac cctttgtaga ttctcatttg 10560 cataacgatc tcatagatac gttatcaacg cgtggtattc ctggagtagc attaacaatt 10620 ttagcctttt cagcaatatt catatatgcc ttaagaactg ctaaagaacc ttatatttta 10680 atcttgcttt tttcactact ggtagtaggc ctaagtgatg taatactctt ttctaaaccg 10740 gttccgactg ctgtgtttgt caccataata ttgctttgtg cttattttaa agtacaatcg 10800 gaccaatgtt tattagataa gtaatgaata tgtgaaataa aatcagcaag gaagctgatt 10860 ttatttcaaa attatctatt aaagagttgt aatttaaatc atggcagctt tttcagcgtt 10920 ttcttcaatg aattgcttaa cagcatttgc tgtcaattga gacaactcat tccccggagc 10980 cctacaaacc atctgattct tcccataccc accaattaat cccggatcgg taggtccata 11040 aaccgtgata ttgggtctat ccagtgccgc cgttaaatgg cttaaccccg tatccaccga 11100 cactacaaat ttagccccgg ccagtacgcg ggcaacgcct tccagactca tcttcggcaa 11160 tacttcaaca taagcaaatc cttccgccag tcgtttcgcc cgttcttcct catgcggcgc 11220 gccccacgga agtttaatcc gtattcctga atcagccagt aaaccaatca attctcgcca 11280 gtgttcttcc ggccagtgtt tatcatctcg ggttgttgca tgaagaaata cggcatattc 11340 gccagcatct gtaggcaggt tcgtcaggaa atgctgtgcg atagcataat cgccctgggt 11400 ttgtggtttg ctatagccca gacttttggc aaacagttcg cgggtgcgtt ctacggcgtg 11460 ctgctgtttt gcaatatgat gtttacgatt gtaaaacagg ctggctaacg gttcgcgagc 11520 ggtttgccag tccattccat gctttacgcc atgcgccaga cgcgtcacca gcgccgcgct 11580 ttttaccagc ccctgggcgt cgataactgc gtcatagttc tttgcttgta gcgcttcacg 11640 aaacgctttg cgttcagctt ttatgggagc cgagaaccag gctttacgcc agcgacgtat 11700 tgccacagga ataactcgct caacggcagc gtgccaggaa ggaatctgtg cgaacccttc 11760 ttccaccacc cagtcaaact taatccctgg gattgcctgc tgggcatcag tgagtgcggg 11820 c 11821 // |
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