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EBI DbfetchID AF416868; SV 1; linear; mRNA; STD; VRT; 6177 BP. XX AC AF416868; XX DT 10-OCT-2001 (Rel. 69, Created) DT 15-APR-2005 (Rel. 83, Last updated, Version 3) XX DE Xenopus laevis breast and ovarian cancer susceptibility protein (BRCA1) DE mRNA, complete cds. XX KW . XX OS Xenopus laevis (African clawed frog) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Xenopus. XX RN [1] RP 1-6177 RX DOI; 10.1073/pnas.211427098 RX PUBMED; 11593018. RA Joukov V., Chen J., Fox E.A., Green J.B., Livingston D.M.; RT "Functional communication between endogenous BRCA1 and its partner, BARD1, RT during Xenopus laevis development"; RL Proc. Natl. Acad. Sci. U.S.A. 98(21):12078-12083(2001). XX RN [2] RP 1-6177 RA Joukov V., Chen J., Fox E.A., Green J.B.A., Livingston D.M.; RT ; RL Submitted (05-SEP-2001) to the EMBL/GenBank/DDBJ databases. RL Cancer Biology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA RL 02115, USA XX FH Key Location/Qualifiers FH FT source 1..6177 FT /organism="Xenopus laevis" FT /mol_type="mRNA" FT /dev_stage="embryo stage 11-18" FT /db_xref="taxon:8355" FT CDS 56..4795 FT /codon_start=1 FT /gene="BRCA1" FT /product="breast and ovarian cancer susceptibility protein" FT /note="BRCA1; nuclear protein" FT /db_xref="GOA:Q90X96" FT /db_xref="HSSP:1JM7" FT /db_xref="InterPro:IPR001357" FT /db_xref="InterPro:IPR001841" FT /db_xref="InterPro:IPR002378" FT /db_xref="InterPro:IPR011364" FT /db_xref="InterPro:IPR017907" FT /db_xref="InterPro:IPR018957" FT /db_xref="UniProtKB/TrEMBL:Q90X96" FT /protein_id="AAL13037.1" FT /translation="MTCSRMDIEGICSVISVMQKNLECPICLELMKEPVATKCDHIFCK FT FCMLQLLSKKKKGTVPCPLCKTEVTRRSLQESHRFKLLVEGQLKIIKAFEFDSGYKFFP FT SQEHTKGLDSTIEDVLVKEDQSIVHCKGYRNRKKGVFNRKTYEETGMLSVSKAEEQFAK FT EVTRLIPCRQKKPKKEAALIFSNCVPDSSDGDLLNKENGLRNDCSPLHYEKEDTQIPEM FT EEMVESDLAECEFAESAGSNLLGFDGPEGIPEISAETSINAAGNCDFYGRKTEQFPNDH FT HCSFKQNIADAEQNKRNQHCGNVPFAPMGKSNLDEKETVETDFDNQHNDSNPENNDPLG FT KVTKLMRRSTERVNEWLLKTNQDFSTLSAEEDPILDALALQNKETSDKRSCSSDDSELM FT PVLHKHAEKGISGGGFDKPAVGVKDKIFCKVYKRERKAMPPNNITCVAEVHHDSALETG FT KENMTLEYGTGMSHLMSKRKMVYSLNPENTSKKNDLANINGSINVFPDCISDANLELED FT KSEADSNSADACQSDIVHSSNTQIKQQCVESLANAGETRKKQELSCERSQEEKDFTQSG FT ALGPKTRSQKSPYGHSELHIESSQISNEPSNVTKQVEVRRSRRLLMLPKGPGNKSNSNA FT VKEMNEQENIAQIPEFRVKDTNKNNEISDTVPSQLKKKDTYFPPCTSEDTGELENGIPV FT RKISDQNASLDNPIDPCKDEYSDTLLHVAGDNVQPDYMETEESELETQHIVKMFKTSKR FT TSFILESKEAENENRVNSAVEISQVETSNELPNVAECRHTSLLSSAKEQSGALLKQGSP FT SSEPKKTSPIHMLKKTESKHSKMSRNRRGKVKPSSNSAKNTTGQPDNLNNPTQGVTGSL FT YNKQVMSDFPMRLNVDEEHTNASAKGSQSSVADKSTAHSNVNTDFISDINSATPDGLLH FT YMDKAEGNSSPWDTTRDKNAALLESCLPSAYGSTGEKTPIPKVQSSEEGSSQGLFNQKP FT KCSSSGKADQKNSSKNPGKSQCRILSDFSGSSNNGKCSSQEMLSKAAFPSLSQESQCSV FT SLFSTQSNMSQQSVDEDHKQDVLQDELVSPNKTKRTAISGTEETQISPLRDQYQNPDID FT EASECESEASHTGDSSILSSQDELLNTQQRNYMKDSLKKLQQEMAALEAVLGQHGTQKL FT EAETTCIPSSEHVTEMQEATEEEEEETYQGENLFVKTPPEHVANGSTLIGQSTDNGLQG FT RNRPVSPSFLCQTRIEKDTPEIVCPAMGISKKSLLTQKELPSQHKQEIRPDLETVNVTP FT TNPIDAQESLRQSSKNKRGSRMLHNKRSTSNQGSFCLSVEAAESPQIPKQNKAEFGIAR FT KSTSPTFASPARAKVPSVGFKSPVVSSRRNLSFVASGLNQCEMALVQRFSKTTQSILSS FT RITDSTTHVIMKTDAELVCERTLKYFQGIASRKWVVSYEWVVQSFREGQILDEYDFEVK FT GDVINGRNHRGPRRSRLGSDGLLLIDFEICFFGSFTDMTLDDLEWMVSECGATVVKKLQ FT FFKKKHNVTSLVIVQPDASTEVRDYTEIRKKHKALVVTREWLMDSVATYRLQKFDAYLA FT " XX SQ Sequence 6177 BP; 2068 A; 1174 C; 1347 G; 1588 T; 0 other; gggaagtgtg tgccctcagc gagcaagttg catttaaggg acaggacaaa gtaaaatgac 60 ctgctcaaga atggatattg aaggcatttg tagcgtgatt tcggtcatgc agaagaattt 120 ggagtgccca atctgcttag agctgatgaa ggaaccagtt gcaacaaagt gtgatcacat 180 attttgcaaa ttttgtatgc tacaacttct cagcaaaaag aagaaaggaa ctgttccgtg 240 ccctttatgc aagaccgaag taactagaag gagtcttcag gaaagtcacc gattcaaact 300 tctggttgaa gggcagctga agattataaa agcctttgag tttgactcgg gatacaaatt 360 ctttccaagt caagaacaca caaaggggtt ggattccaca atcgaggatg tcttggtgaa 420 ggaagatcag tccatagtgc actgcaaagg ttacagaaac cgtaaaaaag gcgtcttcaa 480 cagaaaaacg tatgaagaaa ctggaatgtt atcggtatcc aaagccgaag agcaatttgc 540 taaagaagtt acaagactga ttccttgcag acagaagaaa cctaagaaag aggctgcact 600 cattttcagt aattgtgttc ctgattcttc tgatggtgat ttattgaata aagaaaatgg 660 cttgagaaat gactgctctc cactccacta tgaaaaagaa gacacacaaa ttccagagat 720 ggaagaaatg gtggaatcgg acctagctga atgtgaattt gctgaaagtg caggaagcaa 780 tttattgggt tttgacggtc ctgaaggcat tcctgaaata tcagcagaaa caagtatcaa 840 tgcagctggt aattgtgact tttatggaag aaaaacagag cagttcccta atgaccatca 900 ttgcagcttc aagcaaaata ttgcagatgc agagcaaaac aaaagaaatc agcattgcgg 960 caatgttcct tttgcaccaa tggggaaatc caatttagat gaaaaggaaa ccgtagaaac 1020 tgactttgat aaccagcata atgactcaaa ccctgagaat aatgaccctt taggcaaagt 1080 cactaaatta atgagaagga gcacagaacg ggtcaatgag tggttgctaa aaacaaatca 1140 ggatttcagc actttgtcag cagaggaaga ccctatcctt gatgcattag ctttgcaaaa 1200 taaagagacc tctgacaaaa gatcttgctc ctcagatgac tctgaattaa tgcctgtact 1260 tcataaacat gctgagaagg gtatatcagg tggtggtttt gacaaaccag cagttggcgt 1320 aaaggacaaa atattctgta aagtctacaa gagagagaga aaagctatgc ctccaaataa 1380 tataacctgt gtagctgagg tccatcatga tagtgcttta gagactggca aagaaaatat 1440 gactctggaa tatggcacag gaatgagtca tttaatgtcc aaacggaaaa tggtctacag 1500 tctaaatcct gaaaacactt ccaagaagaa tgacctagct aacataaatg gaagcattaa 1560 tgtttttcct gactgtatat ctgatgccaa tttagagctg gaggataaat cagaggctga 1620 ctctaattct gctgatgcat gtcagtctga catagttcat tccagtaata ctcaaattaa 1680 acaacagtgt gtggaatctt tggcaaatgc aggtgaaacc agaaaaaagc aagagttatc 1740 ttgtgaacga agccaagagg aaaaagactt tactcagtct ggtgcattag gacctaaaac 1800 acgctcacag aaaagtcctt acgggcactc ggagctacat atagaaagtt ctcaaattag 1860 taatgagcca agtaatgtaa caaagcaggt ggaagtgaga cgaagcagaa ggcttttgat 1920 gttgccaaaa ggaccaggaa acaaatcaaa ttcgaatgca gttaaggaaa tgaatgaaca 1980 ggagaatatt gctcagattc cagaatttcg ggtgaaagac acaaataaaa acaatgagat 2040 ttctgataca gttccttcac aacttaaaaa gaaagacaca tacttcccac cttgcacttc 2100 tgaagatact ggtgaattgg agaatgggat tcctgtgaga aaaatcagtg atcagaatgc 2160 ctctttagat aatcctatag acccctgtaa ggatgaatat tcggacacct tgctacatgt 2220 tgcaggggat aatgtgcagc ctgattacat ggaaactgaa gagtcggaac tggaaaccca 2280 acacatagta aaaatgttta aaacttctaa gcggacatcc ttcatattag agtccaagga 2340 agcagaaaat gagaataggg taaactctgc tgtggagatt tcgcaggtcg aaacttctaa 2400 tgagttgcct aatgttgctg aatgcaggca cacttctctg ttaagttcag ctaaagaaca 2460 aagtggtgca ttgctgaaac agggcagccc cagtagtgag cctaaaaaaa ccagcccaat 2520 acacatgctc aaaaaaactg aatcaaaaca tagcaaaatg tcccgcaaca gaagagggaa 2580 agttaaaccc agttctaatt ctgctaaaaa tactactggc cagccagaca atttaaacaa 2640 ccccacccag ggggtcactg gtagcctata taataaacaa gtaatgagtg attttcctat 2700 gaggctcaat gttgatgaag aacatacaaa tgcatcagct aaaggtagcc aaagttcagt 2760 ggctgataaa tccacagcac attctaatgt caatactgac ttcatatctg atattaattc 2820 tgccactcct gatggattgt tgcattacat ggataaggct gaaggaaatt caagcccatg 2880 ggatacaacc agagacaaaa atgcagctct ccttgagagt tgtcttcctt ctgcctatgg 2940 atcaacaggg gaaaaaactc ctataccaaa ggtacaatca tcagaggaag gatcatctca 3000 gggtctattt aatcaaaagc caaagtgctc atcctccggt aaagcagatc agaagaattc 3060 ttctaaaaat ccaggtaaat ctcagtgtag gatcttgtca gatttcagcg gcagcagcaa 3120 taacggaaaa tgcagttcac aggagatgct gtcaaaggca gcctttcctt ctctgagtca 3180 agaatcgcag tgttccgtga gcttgttctc cacacagtca aatatgtctc agcaatctgt 3240 agatgaagac cacaaacaag atgtgctcca ggatgaacta gtcagtccaa ataaaaccaa 3300 acggacagcc atcagtggta cagaagagac acagatttct ccccttcggg accagtatca 3360 gaatcctgat atagatgaag catcagaatg tgagagtgaa gcaagtcata caggagattc 3420 ctctatattg tcttcacagg atgaactcct gaacacccag caacggaatt acatgaagga 3480 cagtttaaag aaactgcagc aagagatggc tgcattggaa gcagtactgg ggcagcatgg 3540 gacccagaaa cttgaagcag agacaacatg catcccttca tctgagcatg tcacagaaat 3600 gcaggaggct actgaagaag aagaagagga gacatatcaa ggagagaact tatttgtaaa 3660 aacccctcca gagcatgttg caaatgggtc aactttgata ggccagagca ctgacaatgg 3720 attgcagggc aggaatcggc cagtgtctcc atcttttcta tgccagacca ggattgagaa 3780 ggatactcca gaaatagtat gcccagcaat gggcatatca aaaaaatctt tgcttacaca 3840 gaaagaactt ccaagccagc ataaacagga aatcagacct gatcttgaga cagttaatgt 3900 gacaccgacc aacccaatag atgcccaaga atctttgagg caaagcagca agaacaagag 3960 agggagccgt atgttgcaca ataaacgttc cacatctaac caaggctcgt tttgtctttc 4020 tgtggaagct gcagagtctc cacaaatccc caaacaaaac aaagcagagt tcggcatcgc 4080 aaggaaatcc acctcaccta cttttgcgtc tccggctcga gccaaagtac cttctgttgg 4140 ttttaagtct cctgtggtgt catcaaggag gaatctgtcc tttgtggctt ctgggttaaa 4200 tcaatgtgag atggcattag tgcaacgatt ttcaaaaaca acccagagca ttttatccag 4260 tcgaattact gattcaacaa ctcatgtcat catgaaaaca gatgcagagc ttgtgtgtga 4320 acgaactcta aagtatttcc aaggaattgc cagtcgaaaa tgggtggtaa gctatgaatg 4380 ggttgtacag tcattcagag aggggcaaat ccttgatgag tatgactttg aagtgaaggg 4440 agatgtgatc aatggaagaa atcatagagg tcccagacga tcaaggctgg gatccgatgg 4500 attgctgcta atcgattttg aaatttgctt ctttggctca ttcactgaca tgacactcga 4560 tgatcttgag tggatggtgt ctgagtgtgg agccactgtg gtgaaaaaac ttcagttctt 4620 taaaaagaaa cacaatgtga catcgcttgt gattgtgcaa cctgatgcta gtacggaagt 4680 ccgagattat actgagatca ggaagaagca caaggcacta gtagtgacgc gtgagtggtt 4740 aatggacagt gttgctactt acagacttca gaagtttgat gcttaccttg cataaaatca 4800 cagtggaact ggccggttat gatacgcgtt tagctcttat cctgtcacta tctacaagtg 4860 ccttctttac attcttatat aattcgctgt ctacctaaat gcactgataa aagctgtgtt 4920 agcatcttca tcacaacagg tttgaagaga acatttagga tggggttctc acaaaagttt 4980 ttgatgctct agttaaagga atgtttgcct aggagcaaca aaaaacctta taaggaggaa 5040 gatcgagctt ctatcagatt ccattacaca gtttagttgg ttactatggc ctaagctttt 5100 gagtctggcc cctatgtgga gacctgaagc agtggcatga ggacttagcc tttaggtgat 5160 ttagggtaaa gtgtgtagat ttcctaagtg ctgtcctata tctgaatgtc ttgcttgaag 5220 tctggttcgg gtgagattag aagacaatgc ctatttgttc tagaaactga aatccaagct 5280 tgaagtccag ttagagaaag attaggggac aatgtaagtt tgtgctagat atgcctaaaa 5340 gcccagtttg aagtctagta atagtgaagt ttggggagaa tgcagtttgt tctctgagat 5400 atacctgaaa gcccagcctg aagataaatt agggtgaaaa tttaggtgaa accattttca 5460 gatctagata ttgtaactat ggcttaatag ccaatatttt catatatctc taaccttgta 5520 agtattgacc aaaggttgga ctccagtgtg aactagaacg gaagctccaa caagctctgt 5580 catattctat gtaatcttga atttaatgtc taagctggcg tgcagagtat cccatatgga 5640 caagagcaag caaactggat tttcctagac tttgttcaca tcagcatgca tactagagga 5700 atagctggcc agacagaggg caggtaataa agaaccttct tccatttata gccagatatg 5760 ggtgcataac ttcataattc aggatccccc ccaccaagtg cttaactgaa ctttatattt 5820 ggatgcataa tctaatactg tatgtttaat gtctgcatct agttaatcgt gctctaatct 5880 catctcgtag ttcatgtaaa acacatagaa aaatttaaag cagcacagtt ttaattcaac 5940 aaaaatttcc aacaaagttc ttactttatc aggcttggga tggttttatc tagctgtgca 6000 taggtaacac cactgcaagt tattaccacg ctgctccgaa atacgtgcaa ttcgccacca 6060 tagttccaaa taaaaagcag aatatgctct cctaatgtgc ttggatggtt ttatttttct 6120 ttcatttttt ttattgtata ttttaaactt gagtagcaac aaaaaaaaaa aaaaaaa 6177 // |
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