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EBI DbfetchID AF378005; SV 1; linear; mRNA; STD; VRL; 3912 BP. XX AC AF378005; XX DT 31-MAY-2001 (Rel. 67, Created) DT 17-MAR-2002 (Rel. 71, Last updated, Version 2) XX DE Mammalian orthoreovirus 2 Jones core-spike protein lambda-2 (L2) mRNA, DE complete cds. XX KW . XX OS Mammalian orthoreovirus 2 D5/Jones OC Viruses; dsRNA viruses; Reoviridae; Orthoreovirus. XX RN [1] RP 1-3912 RX DOI; 10.1006/viro.2001.1052 RX PUBMED; 11531411. RA Breun L.A., Broering T.J., McCutcheon A.M., Harrison S.J., Luongo C.L., RA Nibert M.L.; RT "Mammalian reovirus L2 gene and lambda2 core spike protein sequences and RT whole-genome comparisons of reoviruses type 1 Lang, type 2 Jones, and type RT 3 Dearing"; RL Virology 287(2):333-348(2001). XX RN [2] RP 1-3912 RA Breun L.A., Broering T.J., McCutcheon A.M., Harrison S.J., Luongo C.L., RA Nibert M.L.; RT ; RL Submitted (08-MAY-2001) to the EMBL/GenBank/DDBJ databases. RL Department of Microbiology and Molecular Genetics, Harvard Medical School, RL 200 Longwood Avenue, Boston, MA 02115, USA XX FH Key Location/Qualifiers FH FT source 1..3912 FT /organism="Mammalian orthoreovirus 2 D5/Jones" FT /strain="Jones" FT /isolate="T2/Human/Ohio/1955" FT /serotype="2" FT /mol_type="mRNA" FT /note="core-transcribed mRNA" FT /db_xref="taxon:10885" FT primer_bind 1..2 FT /gene="L2" FT CDS 13..3879 FT /codon_start=1 FT /gene="L2" FT /product="core-spike protein lambda-2" FT /function="guanylyltransferase, 7-N-methyltransferase and FT 2'-0-methyltransferase in reovirus mRNA 5' capping" FT /note="pentameric in virus particles" FT /db_xref="GOA:Q91RA4" FT /db_xref="InterPro:IPR010311" FT /db_xref="UniProtKB/Swiss-Prot:Q91RA4" FT /protein_id="AAK57509.1" FT /translation="MANVWGVRLADSLSSPTLESRNRSYTLHDFCSDLDASAGKEPWKA FT LRNQRTSEIVAVRLFRPLQGLILDTHMYGFPGEFDAWEVFVKEKLRVLKYEVLRVYPIS FT GYSNSHVNVFVANALVGAFLSNQAFYDLLPLLIINDTMINDLLGAGVSLAQFFQAHGDV FT LEVAAGRKYIQMNGYSNDDDDPPLFAKDLSDYAKAFYCESFEVLDRFFWTHDASAGVLV FT HYDKPTNGNHYLLGTLTQMVSAPPFIINATDAMMLESCVEQFAANAAARPAQPATRLDQ FT CYHLRWGAQYVGEDSLTYRLGVLSLLATNGYQLARPIPKQLTNRWLSSFVSQIMSEGAN FT ETPLWPQERYVQIAYDSPSVVDGAVQYGYVRKNQLRLGMRISPIQSLSDVPAPVAWLPQ FT YTIDQTALEDGDMVGHMSQLPLRPEYGSMWVGEALSYYVDYNQSHRVVAAKELPQLPDT FT YFDGDEQYGRSLFSLARRIGDRSLIKDTAVLKHAYQAIDPSTGREYLRAGQSVAYFGAS FT AGHSGADQPLVIEPWLQGKISGVPSPASIRQFGYDVAKGAIVDLARPFPSGDYQFVYSD FT VDQVVDGHDDLSISSNLVESILSSCMQATSPGGSFVAKINFPTRSIWYYIEQKILPNIT FT SYMIIKPFVTNNVEVFFVAFGVHRQSSLTWTSGVYFFLVDHFYRYETLSAISRQLPSYG FT YVDDGSSVTGLEVISIENPGFSTMTQASRVAISALCANTGNSRKTISIYESHGARVLML FT VSRRSPASAKRKARLRYLPLIDPRSLEVQSRTIMPSTPVLFENSNGASPHVCLTMMYNY FT EVSSAVYDGDVVLDLGTGPEAKILELIPPTSPATCVDIRPTAQPTGCWNVRTTFLQLDY FT LSDGWITGVRGDIVTCMLSLGAAAAGKSMTFDAAFQQFVRVIAQSAANVVLVQVNCPTD FT VIRSVRGYLEIDQTSKRYRFPKFGRDEPYSDMESLERICRATWPNCSITWVPLSYDLRW FT TRLALLEAATLNSASIRIAELMYKYMPVMRVDIHGLPMNKSGNFVVGQNCSLTIPGFNA FT QDTFNCYYNSALAFSTEDVNAAMIPSVTATFDNAKNEWTLDMVFSDAGIYTMQAVVGVN FT ASPIALGSFVVDSPDVDITDAWPAQLDFTIAGTDVDITVNPYYRLMAFVKIDGQWQIAN FT PDKFQFFASATGTLTMNVKLDIADKYLLYYIRDVQSREVGFYIQHPLQLLNTITLPTNE FT DLFLSAPDMREWAVKESGNTICILNSQGFIPPQDWDVLTDTISWSPSLPTYVVPPGDYT FT LTPL" FT primer_bind complement(3909..3912) FT /gene="L2" XX SQ Sequence 3912 BP; 971 A; 914 C; 972 G; 1055 T; 0 other; gctattggca ccatggcgaa tgtctggggc gtgaggttag cagattcttt atcgtcacca 60 acacttgaat caagaaatag atcgtatacc cttcatgatt tttgttctga tctggatgca 120 tcagctggaa aggaaccatg gaaagcctta cgtaaccaac gaactagtga gatagtcgct 180 gtgcggctat tcaggccact gcaggggttg atattagata cgcacatgta tggatttcct 240 ggagagtttg atgcttggga ggtcttcgtg aaagaaaaac tgcgtgtgct gaaatatgaa 300 gtcttgagag tgtatccaat tagcgggtat agtaacagtc acgttaacgt ctttgtggct 360 aacgccctcg ttggagcttt cctatctaac caagctttct atgatctact tccgttattg 420 atcattaatg atacaatgat aaatgacctt ctcggtgcgg gtgttagcct ggcacagttt 480 ttccaagccc acggtgatgt actggaagtg gcagccggac ggaaatatat ccaaatgaac 540 ggttactcta atgatgacga tgatccgccg ttatttgcaa aggatttatc cgactatgca 600 aaagcattct attgtgagag ttttgaagtt cttgacagat tcttttggac gcatgacgcc 660 tctgctgggg tattagtgca ttatgacaaa ccaacgaacg gcaaccatta tttactcggg 720 actcttactc aaatggtcag tgctccaccc ttcataatta acgcaactga cgctatgatg 780 ttggagtctt gcgtagaaca atttgcggcg aacgcggcgg cacgtccagc ccaaccagcc 840 actaggttag atcaatgtta ccatttacga tggggcgcgc aatacgtggg tgaggactca 900 ttaacgtata gattgggggt actgtcctta ttggccacta atgggtatca gttagcgcga 960 cctatcccga aacaattgac taacagatgg ctgtcgagct ttgtgagcca aataatgtcc 1020 gagggtgcga atgagacgcc tctttggcct caggagcgtt acgtgcagat tgcttacgac 1080 tctccttcgg ttgtcgatgg ggcagttcaa tacggctacg tccgaaagaa ccagttacgg 1140 ttgggcatgc ggatatctcc catacaatcg ttgagtgacg taccagcgcc agtggcttgg 1200 ttaccccaat acaccattga tcagactgcg ctggaagacg gcgacatggt tggtcacatg 1260 tctcaattgc cacttagacc tgaatatggc agtatgtggg tgggcgaagc tctttcatat 1320 tatgtggatt acaatcagag tcatcgcgtt gtcgcggcga aagaacttcc tcaactacct 1380 gatacgtact ttgatgggga tgagcaatat ggtcggagtc ttttctcact agcacgacgt 1440 attggggacc ggtccctaat taaggatact gcagtgctca agcatgcgta ccaggccata 1500 gaccccagta caggtcgaga gtatctcaga gctgggcagt cagtcgcgta ctttggagcc 1560 tcggccggtc attctggcgc ggatcaacca ttggtcattg agccttggtt acaagggaaa 1620 atcagcggcg tgccctcccc cgcttcgata cgacaattcg gttatgacgt cgctaaggga 1680 gcgattgtcg accttgcccg gccctttcca tcgggggact atcaattcgt ttactcggat 1740 gtagatcaag tagttgatgg acatgatgac ctcagcattt catcgaatct cgtggagagt 1800 atattgtcat cctgcatgca agcaacgtct ccagggggct cattcgttgc aaaaataaac 1860 tttccgacac gctcaatatg gtactacatt gagcagaaga ttttgcccaa tatcacgtct 1920 tatatgatca taaagccctt tgtcacgaat aacgtggagg tgttctttgt agcgttcggt 1980 gttcaccgac agtcgtcatt gacgtggact tctggtgtct actttttctt agtcgaccat 2040 ttctatcgat atgagacact gtctgcgata tccagacaac ttccatcata tggatatgtg 2100 gatgatggtt cctcggtgac tggtctcgaa gtaatcagta tcgagaaccc tggattttca 2160 actatgaccc aagcatcgcg tgtggctata tcggcgttat gcgccaatac gggtaactcg 2220 cgcaagacga tttcgatata cgaatcacac ggagcgcgcg tattaatgct cgtctctagg 2280 cgctctcctg catcagcaaa gcgcaaagcc agactaaggt acctgcccct tattgatccg 2340 agatctctgg aagtgcaatc gcggactatc atgccctcaa ctccagtgtt gtttgaaaac 2400 agtaacggtg cgtctccgca cgtgtgttta acaatgatgt ataattacga agtgtcctcg 2460 gctgtatatg acggtgacgt cgtccttgat cttggaactg ggccggaagc gaagattctt 2520 gaattgattc ctccaacttc accagccaca tgcgtggata tccggccaac ggcgcagccc 2580 acgggatgct ggaacgtgcg aactaccttc ctacaattgg attatttgag tgacggctgg 2640 atcacagggg tgcgtggaga cattgtaacc tgcatgctat cgctaggggc cgctgccgcc 2700 ggcaaatcca tgacgtttga cgctgcgttt caacaattcg tgcgcgttat cgcccaaagc 2760 gccgccaatg tagtattggt tcaagtgaac tgtccaactg atgtgattcg cagtgtgcgt 2820 ggatacttag agatcgatca gacctcaaag agatataggt tcccgaaatt tggacgcgat 2880 gaaccatatt ccgatatgga gtcattagaa cgtatctgta gggccacctg gccaaactgc 2940 tctatcacat gggttccgct atcatacgac ttacgatgga ctaggttagc gttgttggaa 3000 gcagcaacat taaacagtgc ttcgatacga attgctgagc taatgtataa gtacatgccg 3060 gtaatgcgtg ttgacattca cggactgcct atgaataaga gtgggaactt cgttgtgggt 3120 caaaattgct cattgacaat tccagggttt aatgcgcagg acacctttaa ctgctattac 3180 aattcagcac ttgctttttc caccgaagac gtgaatgccg ccatgattcc gagcgtcact 3240 gccacatttg ataatgcgaa aaatgaatgg acattggaca tggtcttttc tgatgccggg 3300 atctacacca tgcaggctgt cgtcggggtt aacgcgagcc cgatagcgtt aggttcattt 3360 gtggtagatt caccagacgt tgatatcacg gacgcttggc ccgcgcaact agacttcaca 3420 attgctggga ctgatgtgga tattacggtt aatccatact atcgattgat ggcatttgtt 3480 aaaattgatg ggcagtggca gatcgcgaat cccgataaat tccaattctt tgcgtccgcg 3540 acggggacac tcacgatgaa tgtcaagctg gacatcgccg acaaatattt gctatattac 3600 atccgtgatg tccaatcccg tgaggtcggg ttctacattc agcatccgct tcaattgctc 3660 aatactatca ctcttcccac taatgaggac ttattcttga gtgcaccaga tatgcgagag 3720 tgggctgtca aggagagcgg gaacactatc tgcattctaa acagtcaagg cttcataccc 3780 ccacaggact gggacgtgtt gacggacacg attagttggt cgccctcgtt gcccacttac 3840 gtcgtgccac ctggtgacta cactctaact cctctgtaac tcatcgctcc tcaggagcgt 3900 gcctaattca tc 3912 // |
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