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EBI DbfetchID AF363393; SV 1; linear; mRNA; STD; HUM; 2312 BP. XX AC AF363393; XX DT 05-SEP-2001 (Rel. 69, Created) DT 07-OCT-2008 (Rel. 97, Last updated, Version 5) XX DE Homo sapiens transglutaminase Z (TGM7) mRNA, complete cds. XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RP 1-2312 RX DOI; 10.1074/jbc.M102553200 RX PUBMED; 11390390. RA Grenard P., Bates M.K., Aeschlimann D.; RT "Evolution of transglutaminase genes: identification of a transglutaminase RT gene cluster on human chromosome 15q15. Structure of the gene encoding RT transglutaminase X and a novel gene family member, transglutaminase Z"; RL J. Biol. Chem. 276(35):33066-33078(2001). XX RN [2] RP 1-2312 RA Aeschlimann D., Grenard P.; RT ; RL Submitted (22-MAR-2001) to the EMBL/GenBank/DDBJ databases. RL Connective Tissue Biology Laboratories, School of Biosciences, Cardiff RL University, Museums Ave, Cardiff CF10 3US, U.K. XX DR ASTD; TRAN00000080094. DR Ensembl-Gn; ENSG00000159495; Homo_sapiens. DR Ensembl-Tr; ENST00000290687; Homo_sapiens. DR Ensembl-Tr; ENST00000452443; Homo_sapiens. DR H-InvDB; HIT000078406. XX FH Key Location/Qualifiers FH FT source 1..2312 FT /organism="Homo sapiens" FT /chromosome="15" FT /map="15q15.2" FT /mol_type="mRNA" FT /cell_line="PC-3" FT /cell_type="prostate adenocarcinoma" FT /db_xref="taxon:9606" FT CDS 6..2138 FT /codon_start=1 FT /gene="TGM7" FT /product="transglutaminase Z" FT /EC_number="2.3.2.13" FT /note="transglutaminase type VII" FT /db_xref="GDB:11520376" FT /db_xref="GOA:Q96PF1" FT /db_xref="HGNC:30790" FT /db_xref="InterPro:IPR001102" FT /db_xref="InterPro:IPR002931" FT /db_xref="InterPro:IPR008957" FT /db_xref="InterPro:IPR008958" FT /db_xref="InterPro:IPR013783" FT /db_xref="InterPro:IPR013808" FT /db_xref="InterPro:IPR014756" FT /db_xref="UniProtKB/Swiss-Prot:Q96PF1" FT /protein_id="AAK97573.1" FT /translation="MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRL FT SFSRPFQSQNDHITFVAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVS FT LFTPANAVIGHYTLKIEISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIM FT RDYGFVYKGHERFITSWPWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYV FT CRVVSAMINSNDDNGVLQGNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWV FT FASVMCTVMRCLGVPTRVVSNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVW FT NECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAE FT VNADEVIWLLGDGQAQEILAHNTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAV FT FMKASRKMLGPQRASLPFLDLLESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPD FT STHPRGPIGLVVRFCAQALLHGGGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKL FT TDEKLIRVSGIAEVEETGRSMLVLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLM FT VALSSCTMVLEGSGLINGQIAKDLGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVK FT EIKGYKDIFVTVAGAP" FT misc_feature join(732..734,1617..1619) FT /gene="TGM7" FT /note="involved in regulation of interaction with glutamyl FT substrate; unclassified site" FT misc_feature join(840..842,1017..1019,1086..1088) FT /gene="TGM7" FT /note="catalytic triad; active site" FT misc_feature join(1212..1214,1353..1355,1368..1370) FT /gene="TGM7" FT /note="involved in Ca2+ complexation; unclassified site" XX SQ Sequence 2312 BP; 526 A; 653 C; 645 G; 488 T; 0 other; gggagatgga tcaggtggca accttgcggc ttgagtctgt cgacctgcag agctccagga 60 acaacaagga gcaccacacg caggagatgg gcgtcaagcg gctcactgtg cgccgcggcc 120 agcccttcta cctccggctg agcttcagcc gacccttcca gtcccagaac gaccacatca 180 cctttgtggc tgagaccgga cccaagccgt cagagctgct ggggacccga gccacattct 240 tcctcacccg ggtccagccc gggaatgtct ggagcgcttc tgatttcacc attgactcca 300 actctctcca agtttccctt ttcacaccag ccaatgcagt tattggccat tacactctga 360 aaatagagat ctctcagggc caaggtcaca gtgtgactta cccgctggga actttcatcc 420 tactttttaa cccttggagt ccagaggacg acgtctacct gccaagtgaa atactgctgc 480 aggagtatat catgcgagat tatggctttg tttacaaggg tcatgaaaga ttcatcacct 540 cctggccctg gaactacggg cagtttgaag aggacatcat agacatctgc tttgagatcc 600 tgaacaagag cctgtatcac ttaaagaacc cggccaaaga ctgttcccag cggaacgacg 660 tggtgtatgt gtgcagggtg gtgagtgcca tgatcaacag caacgatgac aatggcgtgc 720 tgcaggggaa ctggggcgag gactactcca aaggggtcag tcctctggag tggaagggca 780 gtgtggccat cctacagcag tggtcagcca ggggcgggca gcctgtgaag tacggacagt 840 gctgggtctt cgcctctgtt atgtgcaccg taatgagatg cttaggtgtt ccaacccgtg 900 ttgtttccaa tttccgttcc gcgcacaacg tggataggaa cttgaccatc gatacgtact 960 atgaccgaaa tgccgagatg ctgtcaactc agaaacgaga caaaatatgg aacttccacg 1020 tctggaatga gtgctggatg atccggaaag atctcccacc aggatacaac gggtggcagg 1080 ttctggaccc cactccccag cagaccagca gtgggctgtt ctgctgtggc cctgcctctg 1140 tgaaggccat cagggaaggg gatgtccacc tggcctatga cacccctttt gtgtatgccg 1200 aggtgaacgc cgatgaagtc atttggctcc ttggggatgg ccaggcccag gaaatcctgg 1260 cccacaacac cagttccatc gggaaggaga tcagcactaa gatggtgggg tcagaccagc 1320 gccagagcat caccagctcc tacaagtacc cagaaggatc ccctgaggag agagctgtct 1380 tcatgaaggc ttctcggaaa atgctgggcc cccaaagagc ttctttgccc ttcctggatc 1440 tcctggagtc tgggggtctt agggatcagc cagcgcagct gcagcttcac ctggccagga 1500 tacccgagtg gggccaggac ctgcagctgc tgctgcgtat ccagagggtg ccagacagca 1560 cccaccctcg ggggcccatc ggactggtgg tgcgcttctg tgcacaggcc ctgctgcatg 1620 ggggtggtac ccagaagccc ttctggaggc acacagtgcg gatgaacctg gactttggga 1680 aggagacaca gtggccgctc ctcctgccct acagcaatta cagaaacaag ctaacggacg 1740 aaaagctcat ccgcgtgtct ggcatcgcgg aggttgaaga gacagggagg tccatgctgg 1800 tcctaaaaga tatctgtctg gagcctcccc acttgtctat tgaggtgtct gagagggctg 1860 aggtgggcaa ggcgctgaga gtccatgtca ccctcaccaa caccttaatg gtggctctga 1920 gcagctgcac gatggtgctg gaaggaagcg gcctcatcaa tgggcagata gcaaaggacc 1980 ttgggactct ggtggccgga cacaccctcc aaattcaact ggacctctac ccgaccaaag 2040 ctggaccccg ccagctccag gttctcatca gcagcaacga ggtcaaggag atcaaaggct 2100 acaaggacat attcgtcact gtggctgggg ctccctgaga cccgccctcc agctgccctc 2160 cctggcaccc ctgccccacc tggctccttt ctactcctgg ctatgtcgtc ttggctccac 2220 ctctgtcctc tctctagcct gcctgggaat gaatgaagct ctgttagaaa caccgtgtgc 2280 tttgggaaga gacaataaag atgtctttat tt 2312 // |
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