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EBI Dbfetch

ID   AF257214; SV 2; linear; genomic DNA; STD; PRO; 10549 BP.
XX
AC   AF257214;
XX
DT   22-AUG-2000 (Rel. 64, Created)
DT   15-APR-2005 (Rel. 83, Last updated, Version 4)
XX
DE   Brevibacterium sp. HCU cyclohexanol and cyclohexanone oxidation gene
DE   cluster 1, complete sequence.
XX
KW   .
XX
OS   Brevibacterium sp. HCU
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Brevibacteriaceae; Brevibacterium.
XX
RN   [1]
RP   4057-5718
RX   DOI; 10.1128/JB.182.15.4241-4248.2000
RX   PUBMED; 10894733.
RA   Brzostowicz P.C., Gibson K.L., Thomas S.M., Blasko M.S., Rouviere P.E.;
RT   "Simultaneous identification of two cyclohexanone oxidation genes from an
RT   environmental Brevibacterium isolate using mRNA differential display";
RL   J. Bacteriol. 182(15):4241-4248(2000).
XX
RN   [2]
RP   1-10549
RX   DOI; 10.1007/s00253-002-0968-x
RX   PUBMED; 12021799.
RA   Brzostowicz P.C., Blasko M.S., Rouviere P.E.;
RT   "Identification of two gene clusters involved in cyclohexanone oxidation in
RT   Brevibacterium epidermidis strain HCU";
RL   Appl. Microbiol. Biotechnol. 58(6):781-789(2002).
XX
RN   [3]
RP   4057-5718
RA   Brzostowicz P.C., Rouviere P.E.;
RT   ;
RL   Submitted (17-APR-2000) to the EMBL/GenBank/DDBJ databases.
RL   CR&D, DuPont, PO Box 80328 E328/B46, Wilmington, DE 19880-0328, USA
XX
RN   [4]
RC   Sequence update by submitter
RP   1-10549
RA   Brzostowicz P.C., Rouviere P.E.;
RT   ;
RL   Submitted (29-DEC-2000) to the EMBL/GenBank/DDBJ databases.
RL   CR&D, DuPont, PO Box 80328 E328/B46, Wilmington, DE 19880-0328, USA
XX
CC   On Jul 16, 2001 this sequence version replaced gi:9864057.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..10549
FT                   /organism="Brevibacterium sp. HCU"
FT                   /strain="HCU"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:133406"
FT   CDS             352..1728
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="chnR1"
FT                   /product="putative sigma 54 type regulator"
FT                   /db_xref="GOA:Q93QH0"
FT                   /db_xref="InterPro:IPR002078"
FT                   /db_xref="InterPro:IPR002197"
FT                   /db_xref="InterPro:IPR009057"
FT                   /db_xref="InterPro:IPR020441"
FT                   /db_xref="UniProtKB/TrEMBL:Q93QH0"
FT                   /protein_id="AAK73159.1"
FT                   /translation="MIGPRTHLTAVDTERGSDLSEEAVGTNGLGTALTTGSGIQIRGAE
FT                   HYAHFYANAVCTGEPVLHPESGQGLGAIVLSGDESRHSNLLLPLLRGLVARMQLKILRN
FT                   PDDFNFSSLPTIGDSKAADQPYDLFISSDRERINTGSTHLPKMRDHTAPVVGSVSVEGL
FT                   DVGFARDHNGLHTLRLLGDATSAQVLHGETNSSRIVRDERWEGCFAETVSVLRSQRSIV
FT                   LVGEAGVGKATLAALGMRAVDPHRPLNEIDAVRAKVDGWDTVLRSIAENLDAGKGLLIR
FT                   GAEGLTSSERTEIRSLLNATADPFVVLTATIDFDDQSTLTSNATVAPTIVIPPLRQNPE
FT                   RVAPLWDALAGPGWRPARLTAPARKALSQYIWPGNLRELHHIAAMTVQNSAGSDITVDM
FT                   LPDTVRSAPSGATMIERAERHALLQALQQADGNRSQAAAILGVSRATIYRKIKQYKLQE
FT                   "
FT   misc_feature    1788..1916
FT                   /note="similar to Xanthomonas sp. transposon Tn5053
FT                   transposase encoded by GenBank Accession Number L20692"
FT   misc_feature    complement(2510..2653)
FT                   /note="similar to Mycobacterium tuberculosis probable
FT                   transposase encoded by GenBank Accession Number X65618"
FT   CDS             3068..3877
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /transl_except=(pos:3068..3070,aa:Met)
FT                   /gene="chnC1"
FT                   /product="caprolactone hydrolase"
FT                   /db_xref="GOA:Q93QG9"
FT                   /db_xref="InterPro:IPR002168"
FT                   /db_xref="InterPro:IPR013094"
FT                   /db_xref="UniProtKB/TrEMBL:Q93QG9"
FT                   /protein_id="AAK73160.1"
FT                   /translation="MPTTHSSPSEQSDKEVTLTAPHPTDPLGEIYAEWDKEFREHPTMS
FT                   LQLMRWVFEDWQRVTKEPSNVRYEETTEGSVPGIWVLPDEADDAKPFLVLHGGGFALGS
FT                   SNSHRKLAGHLAKQSGRQAFVADFRLAPEHPFPAQIEDALTVISAMNSRGIPTENITLV
FT                   GDSAGASIAIGTVLSLLKDGRALPRQVVTMSPWVDMENSGETIESNDAYDFLITRDGLQ
FT                   GNIDRYLAVERILVTGLVNPLYADFHGFPRLYICVSDTESSTRTASV"
FT   CDS             4057..5718
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="chnB1"
FT                   /product="cyclohexanone monooxygenase 1"
FT                   /EC_number="1.14.13.22"
FT                   /note="flavin-dependent monooxygenase; contains FAD;
FT                   requires NADPH"
FT                   /db_xref="GOA:Q9FDI4"
FT                   /db_xref="InterPro:IPR006076"
FT                   /db_xref="InterPro:IPR013027"
FT                   /db_xref="UniProtKB/TrEMBL:Q9FDI4"
FT                   /protein_id="AAG01289.1"
FT                   /translation="MPITQQLDHDAIVIGAGFSGLAILHHLREIGLDTQIVEATDGIGG
FT                   TWWINRYPGVRTDSEFHYYSFSFSKEVRDEWTWTQRYPDGEEVCAYLNFIADRLDLRKD
FT                   IQLNSRVNTARWNETEKYWDVIFEDGSSKRARFLISAMGALSQAIFPAIDGIDEFNGAK
FT                   YHTAAWPADGVDFTGKKVGVIGVGASGIQIIPELAKLAGELFVFQRTPNYVVESNNDKV
FT                   DAEWMQYVRDNYDEIFERASKHPFGVDMEYPTDSAVEVSEEERKRVFESKWEEGGFHFA
FT                   NECFTDLGTSPEASELASEFIRSKIREVVKDPATADLLCPKSYSFNGKRVPTGHGYYET
FT                   FNRTNVHLLDARGTPITRISSKGIVHGDTEYELDAIVFATGFDAMTGTLTNIDIVGRDG
FT                   VILRDKWAQDGLRTNIGLTVNGFPNFLMSLGPQTPYSNLVVPIQLGAQWMQRFLKFIQE
FT                   RGIEVFESSREAEEIWNAETIRGAESTVMSIEGPKAGAWFIGGNIPGKSREYQVYMGGG
FT                   QVYQDWCREAEESDYATFLNADSIDGEKVRESAGMK"
FT   CDS             5852..7096
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="chnD1"
FT                   /product="Fe-dependent alcohol dehydrogenase"
FT                   /note="6-hydroxyhexanoate dehydrogenase"
FT                   /db_xref="GOA:Q93QG8"
FT                   /db_xref="InterPro:IPR001670"
FT                   /db_xref="InterPro:IPR018211"
FT                   /db_xref="UniProtKB/TrEMBL:Q93QG8"
FT                   /protein_id="AAK73161.1"
FT                   /translation="MESHNENTLGLGLLRQPGTVVFGPGQRRELPSIAKRYGSTVLICT
FT                   DERMLAEPMCIDLQTALEKAGMRVVVYGNVRPDLPRADIQTATRKLAHDKIDVIFGLGG
FT                   GSCMDFAKVMGILLLSPGDVRDIFGENVVSGPGLPVITVPTTGGTGAEATCISVVHDEE
FT                   KGVKVGVASAYMQAVATVIDPEFTLTAPEGLTAATATDALSHLVESYTAYAKNPSSDDI
FT                   RDHLYVGKNLLTDVWAERGLKLISDGIPALAKDLTDLNARTNVMLAAFCGGMGINTTGT
FT                   AGCHALQSPLSALTGTSHGFGVGALLPYVMRYNLPARTPEFARLGELVGADRGSTVLES
FT                   AQHAVEKVEWLVSTIGAPTDLGALGMTEADVAGVAKAAAASTRLIANNPRPLPAEIMEE
FT                   ILLRGVRGDRSWWAE"
FT   CDS             7084..8034
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /product="hydroxyacyl-CoA dehydrogenase"
FT                   /db_xref="GOA:Q93QG7"
FT                   /db_xref="InterPro:IPR006108"
FT                   /db_xref="InterPro:IPR006140"
FT                   /db_xref="InterPro:IPR006176"
FT                   /db_xref="InterPro:IPR006180"
FT                   /db_xref="InterPro:IPR008927"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q93QG7"
FT                   /protein_id="AAK73162.1"
FT                   /translation="MGRVSHVGIFGAGSIGTAFALLFADAGFAVRIFDPDPSALERSRH
FT                   VIDQRITELQRFTLLASNPSEVRELIEIVSSARTAASGAILVQEAGPEDVQTKQHIFED
FT                   LTAVTSDETILASASSAIPSSRFVDVHSAFRSLIGHPGNPPYLLRVVELVGNPSTEEQT
FT                   ILRAGQLYEQAGLSAVRVNREVDGFVFNRIQGAVLREAYALVGAEIIDPMDLDTLVQDG
FT                   LGLRWSVAGPFATVDLNVRGGITAHAERMGSAYHRMAGALDTSKEWTDTLVAKVNCSRR
FT                   KAVPLEQWDQAVADRDTQLMKQLNARTSNGGTTRD"
FT   CDS             8018..8794
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /transl_except=(pos:8018..8020,aa:Met)
FT                   /product="short-chain dehydrogenase"
FT                   /db_xref="GOA:Q93QG6"
FT                   /db_xref="HSSP:1FJH"
FT                   /db_xref="InterPro:IPR002198"
FT                   /db_xref="InterPro:IPR002347"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q93QG6"
FT                   /protein_id="AAK73163.1"
FT                   /translation="MLPVTDSLGGDVFLVTGGAGGIGKATTTALAERGGRVVLTDVDED
FT                   AGSQVADEVRRNTNGEIRFEPLDVTNPAAVTECAQKLDDEGWPVYGLMANAGIAPSSSA
FT                   VDYSDELWLRTVDINLNGVFWCCREFGKRMIARGRGSVVTTSSIAGFRTVSPERHAAYG
FT                   ATKAAVAHLVGLLGVEWAKTGVRVNAVAPGYTRTPILEALKAESPETISEWTERIPNGR
FT                   LNDPSEIADGVVFLMSNAARGITGTVLHIDGGYAAR"
FT   CDS             9132..9902
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="chnA"
FT                   /product="cyclohexanol dehydrogenase"
FT                   /note="similar to short-chain dehydrogenase family
FT                   proteins"
FT                   /db_xref="GOA:Q93QG5"
FT                   /db_xref="HSSP:1Q7B"
FT                   /db_xref="InterPro:IPR002198"
FT                   /db_xref="InterPro:IPR002347"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q93QG5"
FT                   /protein_id="AAK73164.1"
FT                   /translation="MNRLGGKVAVITGGAAGMGRIQSELYASEGAQVAVVDVNEQEGRA
FT                   TADAIRASGGVANYWKLDVSDESEVEIVVSDIAKRFGAINVLVNNAGVTGADKPTHEID
FT                   ERDLDLVLSVDVKGVFFMTKHCIPYFKQAGGGAIVNFASIYGLVGSQELTPYHAAKGAV
FT                   VALTKQDAVTYGPSNIRVNAVAPGTILTPLVKELGSRGPDGLDGYTKLMGAKHPLGRVG
FT                   TPEEVAAATLFLASEEASFITGAVLPVDGGYTAQ"
FT   misc_feature    complement(9954..10541)
FT                   /note="similar to para-aminobenzic acid synthase from
FT                   Streptomyces encoded by GenBank Accession Number U60417"
XX
SQ   Sequence 10549 BP; 2528 A; 2895 C; 2842 G; 2284 T; 0 other;
     cttgcgacat ctgtacatca ttctcccacc agcgaaggtg gttgacgtta gggatgttcg        60
     cattggatcc tgatgatctc caagaagcta agaaggctgt tctcgctgcc gtaggcagcc       120
     acggtaaaca tgcaacaagt ttgttggatt cttggggccg gtctcacttg agattcggcg       180
     ctccagacgc cgtcaacgag gtaccacatg cgtccgatga cgagatcgac aatgctcttt       240
     tcgacctctg tcgagatcag atccagtcat tcgctggtga acttgagggg tcgggccagg       300
     gcattctttt gtctgatgca gcgggccgtg tggtagaaac ctggacaagc gatgatcggg       360
     ccaagaacac atttgactgc tgtagatact gaacgcggtt cagacctatc cgaagaggct       420
     gtgggaacga atggattggg caccgcactt accactggct cgggaatcca aatccgtggc       480
     gccgaacact atgcacactt ttacgccaat gctgtgtgca caggtgaacc agtcctacat       540
     cccgagtcgg gtcagggcct tggagcgatt gtgctctccg gtgacgaaag tcgtcactct       600
     aacttactcc tcccgttgct ccgaggcctc gtcgcacgaa tgcagctgaa aatccttcgt       660
     aatccggacg acttcaactt cagttcgttg cccaccatcg gcgactcaaa agcggccgac       720
     caaccatacg acctattcat ttcgtcagac agagagcgaa tcaacacagg gagcacgcac       780
     ttacccaaga tgcgcgacca cactgcccca gttgttggga gtgtgtcggt tgaaggactc       840
     gatgttgggt tcgcccgcga tcataatggt ctccatacgc tcagactttt gggggatgcc       900
     acatctgccc aagtgctcca tggcgagacg aactcctcaa gaatcgttcg cgacgaacgt       960
     tgggagggct gcttcgctga aactgtgtcc gttttacgaa gtcaacgatc catcgtgttg      1020
     gtgggcgagg ctggagtagg caaagcaact ctcgccgctc tgggaatgag agccgtggat      1080
     cctcaccggc cgcttaacga gattgacgca gtacgagcca aagtggatgg ctgggacact      1140
     gtccttcgat cgatcgctga gaatcttgac gctggcaaag gactactcat ccgtggagca      1200
     gaagggctca cgagcagcga acgtacggag attcgatcac tgttaaatgc aaccgccgat      1260
     cccttcgtcg tcttgacagc cacaatcgac tttgacgatc aatccacact tacttcgaac      1320
     gccacagtcg cgccaactat tgtcattcca ccactacgcc aaaacccaga acgtgtcgcc      1380
     cccctgtggg acgccctcgc cgggccggga tggcgacccg caagactgac cgcccccgcg      1440
     cggaaagcac tttcccaata catctggccc gggaacctaa gggagcttca ccacattgcc      1500
     gcaatgaccg tgcaaaacag tgctggctca gatattaccg tcgatatgct tcctgacacc      1560
     gtccgatcag caccttcagg agcgacaatg atcgaaagag cggaacggca cgcgctcctt      1620
     caggctctcc aacaagcaga tggaaatcgg tctcaggctg cagcaatcct cggtgtctct      1680
     cgggcaacca tctatcgcaa gattaagcaa tacaaacttc aggaataaca ctctccgggc      1740
     tccacacgaa gatgtatatt ctcgcttgcc catgacgtca tttaggtctg gacaggtgcg      1800
     caccgtcacg cttggagccg ggttcctgta cgagctcgcc acataatctg tgaagcttcc      1860
     atcatgaaat cttctgcgcc tgcaaggcca ggaatgttcc gctgccgctc cgaaatagaa      1920
     gtgatactta ctccgagtat gatcgggctt caccctccgt cgtaaataat tgcgtagtca      1980
     tcgcggacgc aaacgttgtt acaccactgc ctccccgatc aacgcgtgcc accttggtgc      2040
     taaagggccc cgtacgtgcc cagaataccc tcgtccaata ccgccacttt cttgcacagc      2100
     accgaagatt tgcaaaaacc gttaagcgat ttcccgcggt atagattcag acgaattgtt      2160
     ggaggggctt tctacaaggt aactgagcag gtccactact tcaccggtgc tcgttggtcc      2220
     gttgataacc ccggtcattc cgccattgga taagcgtgca cggccttcgg ctggccccac      2280
     tctggactgt tgcaggaagt ggctagccaa ttgagtagcg gacacgctcc gaagctcgat      2340
     agtcgtcgag ttaaacactg gccctgcgcc aatacaccag cagcttctcc ggtggcccag      2400
     aggacatcac caaccgattc ctttaacgcg aatgaaacct ccatcggaga gcatgtgggc      2460
     cagggtccga ccctatgagc cgtcggcgcg tagcgacggt agagtttcct actgttcgcc      2520
     agggtccgaa atgctcacga actaggtcac gccagactct gacaaccagg tatcggaaga      2580
     cgatcccctc gacgcctgtt ctcgagcagt cggggcttct tccgggtatt cgaggacagc      2640
     ggttccattc gcgtccattg gtctttgccg aagcctcagc gccgttgccg tgtagtccct      2700
     tatccagcgt gtcagcccaa agacctcgga tagaggagac ataccctggc ttcgcggctc      2760
     gaccactcgc ccgcggagtt atctcgtaag cttcgatcga gtgcgcggag actccgacct      2820
     cctcgtctca gaaagtcggg gaacacagat tgttcgccgg atagacattg acaagatctc      2880
     taccttgact cggacctcct gccactcacc ctccaacaat catgactaag cgtggcacca      2940
     acgagagacc tggaccggaa aagatccaca ttcgaagggg caaaacttcc acttgtgtct      3000
     caaactgcga ctccgttgct tcaacctgag aatcgacttc ccatcggttc aacccccttg      3060
     aacactggtt ccaacgactc attcgagtcc ctcggaacag tcagataagg aggtcacgtt      3120
     gactgcgccc caccccacag acccacttgg cgagatttac gccgaatggg ataaggaatt      3180
     tcgcgaacac cccaccatgt cattgcaact tatgagatgg gtcttcgaag attggcagcg      3240
     tgtaacaaaa gaaccgtcaa acgttcgcta cgaagagaca accgaaggca gcgttccagg      3300
     catctgggtg ctccccgacg aagcggacga cgccaagccc ttcctggttc tccacggtgg      3360
     aggcttcgca ctgggctcgt cgaatagcca tcgcaaattg gccggccatc tagccaagca      3420
     aagcggcaga caagcttttg tcgccgactt ccgcctagcc cccgaacacc catttccagc      3480
     acagatagaa gatgcgctca ccgtcatctc cgcgatgaat agtcggggca tccccactga      3540
     gaacatcaca ctggtcggcg acagcgcagg agcgagcatc gcgatcggaa ctgttctttc      3600
     actgttaaaa gacggaagag ctctcccccg acaggtcgtc accatgtctc cttgggtgga      3660
     tatggaaaac tccggtgaga ctatcgagtc aaacgacgca tacgacttcc tcatcacccg      3720
     ggatggacta cagggaaaca ttgaccgcta cctggcagtg gagcggatcc tcgtgacggg      3780
     actggtaaat ccgctatacg cagatttcca tgggtttccc cgactgtaca tctgcgttag      3840
     tgacaccgag tcctctacgc ggacagcatc cgtctagccg aacgtgcgaa gactgccaat      3900
     gtcgacgtaa cgctgtcggt agaacaaggc cagcaacacg tgttccccat gcaagcaggc      3960
     aaccaccctg cagccgacaa agcgatctcg gaaatcgtcg cttggtgcca ctgaaaacca      4020
     aacaacatct cttcaacgtt gaaagatcga ggaaccatgc caattacaca acaacttgac      4080
     cacgacgcta tcgtcatcgg cgccggcttc tccggactag ccattctgca ccacctgcgt      4140
     gaaatcggcc tagacactca aatcgtcgaa gcaaccgacg gcattggagg aacttggtgg      4200
     atcaaccgct acccgggggt gcggaccgac agcgagttcc actactactc tttcagcttc      4260
     agcaaggaag ttcgtgacga gtggacatgg actcaacgct acccagacgg tgaagaagtt      4320
     tgcgcctatc tcaatttcat tgctgatcga cttgatcttc ggaaggacat tcagctcaac      4380
     tcacgagtga atactgcccg ttggaatgag acggaaaagt actgggacgt cattttcgaa      4440
     gacgggtcct cgaaacgcgc tcgcttcctc atcagcgcaa tgggtgcact tagccaggcg      4500
     attttcccgg ccatcgacgg aatcgacgaa ttcaacggcg cgaaatatca cactgcggct      4560
     tggccagctg atggcgtaga tttcacgggc aagaaggttg gagtcattgg ggttggggcc      4620
     tcgggaattc aaatcattcc cgagctcgcc aagttggctg gcgaactatt cgtattccag      4680
     cgaactccga actatgtggt tgagagcaac aacgacaaag ttgacgccga gtggatgcag      4740
     tacgttcgcg acaactatga cgaaattttc gaacgcgcat ccaagcaccc gttcggggtc      4800
     gatatggagt atccgacgga ttccgccgtc gaggtttcag aagaagaacg taagcgagtc      4860
     tttgaaagca aatgggagga gggaggcttc cattttgcaa acgagtgttt cacggacctg      4920
     ggtaccagtc ctgaggccag cgagctggcg tcagagttca tacgttcgaa gattcgggag      4980
     gtcgttaagg accccgctac ggcagatctc ctttgtccca agtcgtactc gttcaacggt      5040
     aagcgagtgc cgaccggcca cggctactac gagacgttca atcgcacgaa tgtgcacctt      5100
     ttggatgcca ggggcactcc aattactcgg atcagcagca aaggtatcgt tcacggagac      5160
     accgaatacg aactagatgc aatcgtgttc gcaaccggct tcgacgcgat gacaggtacg      5220
     ctcaccaaca ttgacatcgt cggccgcgac ggagtcatcc tccgcgacaa gtgggcccag      5280
     gatgggctta ggacaaacat tggtcttact gtaaacggct tcccgaactt cctgatgtct      5340
     cttggacctc agaccccgta ctccaacctt gttgttccta ttcagttggg agcccaatgg      5400
     atgcagcgat tccttaagtt cattcaggaa cgcggcattg aagtgttcga gtcgtcgaga      5460
     gaagctgaag aaatctggaa tgccgaaacc attcgcggcg ctgaatctac ggtcatgtcc      5520
     atcgaaggac ccaaagccgg cgcatggttc atcggcggca acattcccgg taaatcacgt      5580
     gagtaccagg tgtatatggg cggcggtcag gtctaccagg actggtgccg cgaggcggaa      5640
     gaatccgact acgccacttt tctgaatgct gactccattg acggcgaaaa ggttcgtgaa      5700
     tcggcgggta tgaaatagcc cagcagtctc gttcgggccc tcaccctgtg gccaagcccc      5760
     acgtctcggc ggcaagctga tcgctcaaaa cacttgcagc cgcgtctgct cgaaaccgca      5820
     atctttcaac caacgaagat ggtgaacatt tatggagtcg cacaacgaaa acacacttgg      5880
     cctcggatta ctacgccaac ccggcactgt agtgttcggc ccagggcaga gacgtgagct      5940
     cccgtccata gccaaacgtt acggttcgac cgtattgatc tgcaccgacg aacgcatgct      6000
     cgctgaacca atgtgtattg acttgcaaac agcgttggaa aaagcgggaa tgcgtgtcgt      6060
     tgtatacgga aatgtgcgtc ctgacttacc ccgagccgac attcagactg caacacggaa      6120
     acttgcccac gacaaaatcg atgtcatctt cggtcttggc ggaggaagct gcatggactt      6180
     cgcaaaggtt atggggatcc tacttctgtc cccaggcgac gtccgtgaca tcttcggcga      6240
     aaacgtcgtc tccggccccg gtttacccgt aatcactgtg cccaccactg gaggtaccgg      6300
     ggccgaggcg acttgtattt cagtggtgca cgatgaggaa aaaggcgtga aggttggggt      6360
     cgcaagtgcc tatatgcagg ctgtggccac cgtcatcgat ccagagttca cgcttactgc      6420
     cccagagggg ctgacggctg cgacggcgac ggatgcactc tcacatctgg tggagtcgta      6480
     caccgcgtac gcgaaaaatc cctcctcgga cgatattcgg gatcaccttt atgtcggtaa      6540
     gaacctgctg acagacgtat gggctgaacg tgggctcaag ctcatttcgg acgggattcc      6600
     tgccctggca aaagatctca ctgatctcaa cgcacgtacc aatgtcatgc ttgccgcttt      6660
     ctgcggcggg atgggaatca acactaccgg cacggcagga tgtcatgccc ttcaatcacc      6720
     gctcagtgcg ttgactggaa catcgcacgg cttcggggtg ggcgcgctgc ttccttacgt      6780
     gatgcggtac aacttaccag ctcgtacacc agagtttgca cgtctcggtg agctagttgg      6840
     ggcggaccgt ggaagcactg ttttggaaag tgcccagcat gccgtcgaga aagttgaatg      6900
     gctagtgtca actattgggg cgcccacaga tttaggtgcc ttggggatga ccgaggcgga      6960
     tgtggcgggc gtcgctaaag ccgcagctgc ttcaacccgt ctcatagcca acaacccccg      7020
     acctttacca gccgaaatca tggaagaaat tctgttgcgg ggagttcgcg gagatagaag      7080
     ctggtgggcc gagtgagcca cgtagggatt ttcggcgctg gctctatagg tacagccttt      7140
     gcgctactgt tcgctgatgc tggcttcgct gttcggatct ttgatcctga tccatcagct      7200
     ctggaacgat caagacatgt catcgatcag cgaatcacgg aacttcaacg attcacctta      7260
     ttggcatcga atccaagtga agttcgtgag ctcattgaaa tcgtttcatc tgctcgaact      7320
     gcggcatctg gagcaattct tgtccaggaa gcaggacctg aagatgtcca gactaagcaa      7380
     catatatttg aagatctaac tgcggtcact agcgacgaaa cgattttggc gagtgcgtcc      7440
     tcagcaattc cttcgagcag attcgtagac gttcattcag cgtttcgatc gttgattggc      7500
     catccgggta atccacctta cttgcttcgc gtggttgaac tagtgggtaa tccgtcgact      7560
     gaggagcaga ccatattaag ggctggacag ctatatgagc aggccggtct gtccgctgta      7620
     cgtgtgaatc gagaggttga cgggttcgtc ttcaatcgga tccagggcgc tgtacttcgt      7680
     gaagcgtatg cgctcgtcgg agctgagatt atagatccta tggacctaga cacacttgtt      7740
     caagatggtt taggtcttcg ctggtccgtc gccggcccgt ttgcgacagt tgatttgaac      7800
     gtacgtggtg ggatcacagc tcatgccgaa cgaatgggat ctgcctatca ccggatggcc      7860
     ggcgccttgg acacttccaa agaatggacc gacacgctgg ttgccaaggt gaactgctct      7920
     agacgcaaag ccgtgcccct cgagcagtgg gaccaagctg tagccgaccg agatacgcaa      7980
     ctaatgaagc aattgaacgc acgaacttct aacggaggta ctacccgtga ctgactcatt      8040
     aggtggagac gtctttctcg ttactggcgg tgctggcggt atcggaaaag ccacgacgac      8100
     ggcacttgca gaacgtggcg gtcgggtggt cttgaccgat gttgatgaag acgctggctc      8160
     tcaagtcgcc gacgaagtgc ggcgcaacac taacggtgag attcgctttg agccgttgga      8220
     tgtaacaaac cccgcagcgg ttactgagtg cgcgcaaaag ctcgatgatg aaggttggcc      8280
     cgtgtacggc ctcatggcca atgcgggtat cgccccaagt tcatcagcgg tcgactactc      8340
     cgatgaactg tggcttcgga ccgtggacat caacctcaat ggagtgttct ggtgctgccg      8400
     cgaattcgga aagcgaatga ttgctcgagg tcgcgggtcg gtagtcacta cttcatctat      8460
     tgcaggtttc cggactgtgt cgcccgagcg ccacgcagcg tatggagcca ctaaggccgc      8520
     ggtcgcccat cttgtcgggc tactcggcgt cgagtgggca aaaaccggtg tgcgggtcaa      8580
     cgcggtcgca ccgggctata cgcgaacacc gatcctcgaa gctttgaaag ccgaatctcc      8640
     cgaaacaatc agcgaatgga ctgaacgtat cccaaatgga cgattgaatg atccatcgga      8700
     aatcgccgat ggggtggttt tcctcatgtc gaatgcagcc agaggcataa ctggaacggt      8760
     actgcacatc gacggtggat acgctgccag gtagagaaaa gagtcctcga tctactctgt      8820
     ccgtccagca ccatcgtctg ggtccatcaa tacgtttatt tacttgtgac gcctcaatat      8880
     caagattcag aatttgtaat tgtccaaccc cagaactcca cactggaatc cggacgatcg      8940
     cttaattcac cgtactcttt cggcattcga attgaacagt gaataacgag attccactca      9000
     aggcgagaga tagagcagag tcaccaattg cagctgcaag aattaggcat tttgtaattt      9060
     cttattatga cacgaaaacc gtacacagta cacagaacaa tacaatttca acctgacatt      9120
     gggagataac aatgaatcga ctcggcggaa aagtagcagt cattactggg ggcgccgcag      9180
     gcatggggcg catacagtct gaactgtatg cgagtgaggg tgcacaagta gcggtagtag      9240
     atgtcaatga acaagaaggc cgtgccactg ccgatgcgat aagggccagc ggcggggttg      9300
     caaactattg gaaattggac gtttctgacg agtctgaagt tgaaatagtc gtctccgaca      9360
     ttgccaagag attcggtgcg attaacgtac tagtgaacaa cgcaggcgtc accggtgccg      9420
     ataaaccaac tcacgagatc gacgaacggg acctggacct cgtactgagc gtcgatgtga      9480
     aaggagtatt cttcatgaca aaacactgca tcccctactt taaacaggct ggcggcggag      9540
     ccatcgtcaa cttcgcgtct atctatggtc tggtggggtc gcaggagctt accccgtacc      9600
     acgcagccaa aggtgcggtc gttgccctta ccaaacagga cgcggtgact tacggaccgt      9660
     caaatatccg agtgaatgcg gtagcacccg gaaccatttt gactccacta gtcaaggagc      9720
     tcggttcaag gggccccgat ggcttagatg gatatactaa acttatgggt gccaagcatc      9780
     cgcttggtcg ggtaggaacc cccgaagaag tcgcggcagc aacattgttt ctggcatccg      9840
     aagaagcttc gttcattact ggcgccgtcc ttcccgttga cggtggatat actgcgcagt      9900
     gacattctca ggacgcggac gcaattcttg tgacagaatt ggttcacctc gcctgtatac      9960
     tgcccctcac caaaactgca ataaacgacc ggacgaggca ccgatttttg aagttgacag     10020
     gattacgcac tttaccggac agacgtagct gtgatcggct aaccatagac gttggaaggc     10080
     ttcttcgatg acgatcgact ccgtcacaat acgcaggaat ggttgttggt cggtgagcct     10140
     gtgtacagga agtaatattt tggtaaccct cggcatagat cgcagttggg gcagtggcgt     10200
     ctgactcaaa ccgccggacg acaaatcatc ggcgaaagaa gccggtccgc atctcgaact     10260
     gcactggtca caagatagag cttcatcgat gcccgaggca cacgcctagt acgggaatca     10320
     acgagtgttc gatagcctcg gcgcagaggc cgaagtcggc cgttctccct gatgttcctg     10380
     gtcccggcga gataactaat gactatgttg tcgaactcgt cgagcacgct cgcctcgaac     10440
     tcagctcagt ctttggacac gagaatcgga gcgcacgcgt tcacctcggc aaggaggtga     10500
     aagaggttca acgtgaacga atcggcattg tcgatgagca gagtgcggg                 10549
//


  
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