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EBI DbfetchID AF215659; SV 1; linear; genomic DNA; STD; PRO; 11474 BP. XX AC AF215659; XX DT 02-JAN-2001 (Rel. 66, Created) DT 26-APR-2006 (Rel. 87, Last updated, Version 3) XX DE Campylobacter jejuni lipooligosaccharide biosynthesis locus, partial DE sequence. XX KW . XX OS Campylobacter jejuni OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; OC Campylobacteraceae; Campylobacter. XX RN [1] RP 1-11474 RX DOI; 10.1074/jbc.M512183200 RX PUBMED; 16481326. RA Houliston R.S., Endtz H.P., Yuki N., Li J., Jarrell H.C., Koga M., RA van Belkum A., Karwaski M.F., Wakarchuk W.W., Gilbert M.; RT "Identification of a sialate O-acetyltransferase from Campylobacter jejuni: RT demonstration of direct transfer to the C-9 position of terminalalpha-2, RT 8-linked sialic acid"; RL J. Biol. Chem. 281(17):11480-11486(2006). XX RN [2] RP 1-11474 RA Gilbert M., Michniewicz J., Wakarchuk W.W.; RT "The LOS biosynthesis locus of Campylobacter jejuni O:4"; RL Unpublished. XX RN [3] RP 1-11474 RA Gilbert M., Michniewicz J., Wakarchuk W.W.; RT ; RL Submitted (12-DEC-1999) to the EMBL/GenBank/DDBJ databases. RL Institute for Biological Sciences, National Research Council of Canada, 100 RL Sussex drive, Ottawa, Ontario K1A 0R6, Canada XX DR StrainInfo; 130227; ATCC 43432. XX FH Key Location/Qualifiers FH FT source 1..11474 FT /organism="Campylobacter jejuni" FT /strain="ATCC 43432" FT /serotype="O:4" FT /mol_type="genomic DNA" FT /db_xref="taxon:197" FT CDS <1..360 FT /codon_start=1 FT /transl_table=11 FT /product="heptosyltransferase I" FT /note="ORF-01; similar to RfaC from Helicobacter pylori" FT /db_xref="GOA:Q9F0N4" FT /db_xref="InterPro:IPR002201" FT /db_xref="UniProtKB/TrEMBL:Q9F0N4" FT /protein_id="AAG43973.1" FT /translation="KEYEFAKEVLNLSGIDETHIELAPKFSLEELMAFTKMMDLIIGND FT SGPTHLAFALNKASITIFGATPSYRNAFQTHINKIIDAGKKIQNAKHIDKSDFCITRIE FT EEDIFKLAKGLLNEK" FT CDS 350..1237 FT /codon_start=1 FT /transl_table=11 FT /product="acyltransferase" FT /note="ORF-02; similar to WaaM from Helicobacter pylori" FT /db_xref="GOA:Q9F0N3" FT /db_xref="InterPro:IPR004960" FT /db_xref="UniProtKB/TrEMBL:Q9F0N3" FT /protein_id="AAG43974.1" FT /translation="MKNSDRIYLSLYYILKFFVTFMPECILHFLALIVARITFYLNKKH FT RKIIDINLQICFPQYTQKERDKLSLKIYENFAQFGIDCLQNQNTTKEKILNKVNFINEN FT LLIDALALKRPIIFTTAHYGNWEILSLAYAAKYGAISIVGKKLKSEIMYEILSQNRTQF FT DIELIDKKGGIRQMLSALKKGRALGILTDQDCVEKESVRLKFFNKEVNYQMGASLIAQR FT SNALIIPVYAYKEGGKFCIEFFKAKDSQNASLEELTLYQAQSCEEMIKKRPWEYFFFHR FT RFASYNEEIYKGAK" FT CDS 1234..2490 FT /codon_start=1 FT /transl_table=11 FT /product="glycosyltransferase" FT /note="ORF-03; similar to LgtF from Neisseria meningitidis" FT /db_xref="GOA:Q9F0N2" FT /db_xref="InterPro:IPR001173" FT /db_xref="InterPro:IPR019290" FT /db_xref="UniProtKB/TrEMBL:Q9F0N2" FT /protein_id="AAG43975.1" FT /translation="MNLKQISVIIIVKNAEQTLLECLNSLKDFDEIILLNNESIDNTLN FT IANKFKKDFANLYIYHNAFIGFGALKNLALSYAKNDWILSIDADEVLENECIKELKNLK FT LQEDNIIALSRKNLYKGEWIKACGWWPDYVLRIFNKNFTRFNDNLVHESLVLPSNAKKI FT YLKNGLKHYSYKDISHLIDKMQYYSSLWAKQNIHKKSGVLKANLRAFWTFFRNYFLKNG FT FLYGYKGFIISVCSALGTFFKYMKLYELQRQKPKTCALIIITYNQKERLKLVLDSVKNL FT AFLPNEVLIADDGSKEDTARLIEEYQKDFPCPLKHIWQEDEGFKLSKSRNKTIKNADSE FT YIIVIDGDMILEKDFIKEHLEFAQRKLFLQGSRVILNKKESEEILNKDDYRIIFNKKDF FT KSSKNSFLAKIFYSLSKKR" FT CDS 2786..3955 FT /codon_start=1 FT /transl_table=11 FT /product="glycosyltransferase" FT /note="ORF-04; local similarity (N-terminus) to Cps14J from FT Streptococcus pneumoniae" FT /db_xref="GOA:Q9K317" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q9K317" FT /protein_id="AAG43976.1" FT /translation="MKKIGVVIPIYNVEKYLRECLDSVINQTYTNLEIILVNDGSTDEH FT SLNIAKEYTLKDKRITLFDKKNGGLSSARNIGIEYFSGEYKLKNKTQHIKENSLIEFQL FT DGNNPYNIYKAYKSSQAFNNEKDLTNFTYPSIDYIIFLDSDNYWKLNCIEECVIRMKNV FT DVLWFDHDCTYEDNIKNKHKKTRMEIFDFKKECIITPKEYANRALSVGSRDISFGWNGM FT IDFNFLKQIKLKFINFIINEDIHFGIILFASANKIYVLSQKLYLCRLRANSISNHDKKI FT TKANVSEYFKDIYETFGENAKEAKNYLKAASRVITALKLIEFFKDQKNENALAIKETFL FT PCYAKKALMIKKFKKDPLNLKEQLVLIKPFIQTKLPYDIWKFWQKIKNI" FT gene 4025..5068 FT /gene="cgtA" FT CDS 4025..5068 FT /codon_start=1 FT /transl_table=11 FT /gene="cgtA" FT /product="beta-1,4-N-acetylgalactosaminyltransferase" FT /note="glycosyltransferase; similar to CgtA from FT Campylobacter jejuni OH4384 encoded by GenBank Accession FT Number AF130984" FT /db_xref="GOA:Q9F0N1" FT /db_xref="InterPro:IPR010446" FT /db_xref="UniProtKB/TrEMBL:Q9F0N1" FT /protein_id="AAG43977.1" FT /translation="MLFQSYFVKIICLFIPFRKIRHKIKKTFLLKNIQRDKIDSYLPKK FT TLVQINKYNNEDLIKLNKAIIREGHKGYFNYDEKSKDPKSPLNPWAFIRVKNEAITLKA FT SLESILPAIQRGVIGYNDCTDGSEEIILEFCKQYPSFIPIKYPYEIQIQNPKSEENKLY FT SYYNYVASFIPKDEWLIKIDVDHIYDAKKLYKSFYIPKNKYDVVSYSRVDIHYFNDNFF FT LCKDNNGNILKEPGDCLLINNYNLKWKEVLIDRINNNWKKATKQSFSSNIHSLEQLKYK FT HRILFHTELNNYHFPFLKKHRAQDIYKYNWISIEEFKKFYLQNINHKIEPSMISKETLK FT KIFLTLF" FT gene complement(5054..5959) FT /gene="cgtB" FT CDS complement(5054..5959) FT /codon_start=1 FT /transl_table=11 FT /gene="cgtB" FT /product="beta-1,3-galactosyltransferase" FT /note="glycosyltransferase; similar to CgtB from FT Campylobacter jejuni OH4384 encoded by GenBank Accession FT Number AF130984" FT /db_xref="GOA:Q9F0N0" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q9F0N0" FT /protein_id="AAG43978.1" FT /translation="MFKISIILPTYNVEQYIARAIESCINQTFKDIEIIVVDDCGNDNS FT INIAKEYSKKDKRIKIIHNEKNLGLLRARYEGVKVANSPYIMFLDPDDYLELNACEECI FT KILDEQDEVDLVFFNAIVESNVISYKKFDFNSGFYSKKEFVKKIIAKKNLYWTMWGKLI FT RKKLYLEAFASLKLEKDVKINMAEDVLLYYPMLSQAQKIAYMNCNLYHYVPNNNSICNT FT KNEVLVKNNIQELQLVLNYLRQNYILNKYCSVLYVLIKYLLYIQIYKIKRTKLMVTLLA FT KINILTLKILFKYKKFLKQC" FT gene 6048..6923 FT /gene="cst-II" FT CDS 6048..6923 FT /codon_start=1 FT /transl_table=11 FT /gene="cst-II" FT /product="alpha-2,3-sialyltransferase" FT /note="sialyltransferase; activity determined FT experimentally" FT /db_xref="GOA:Q9F0M9" FT /db_xref="InterPro:IPR009251" FT /db_xref="UniProtKB/TrEMBL:Q9F0M9" FT /protein_id="AAG43979.1" FT /translation="MKKVIIAGNGPSLKEIDYSRLPNDFDVFRCNQFYFEDKYYLGKKC FT KAVFYTPGFFFEQYYTLKHLIQNQEYETELIMCSNYNQAHLENENFVKTFYDYFPDAHL FT GYDFFKQLKEFNAYFKFHEIYFNQRITSGVYMCAVAIALGYKEIYLSGIDFYQNGSSYA FT FDTKQENLLKLAPDFKNDRSHYIGHSKNTDIKALEFLEKTYKIKLYCLCPNSLLANFIE FT LAPNLNSNFIIQEKNNYTKDILIPSSEAYGKFSKNINFKKIKIKENVYYKLIKDLLRLP FT SDIKHYFKGK" FT CDS 6924..7964 FT /codon_start=1 FT /transl_table=11 FT /product="sialic acid synthase" FT /note="ORF-08; similar to SiaC from Neisseria meningitidis" FT /db_xref="GOA:Q9F0M8" FT /db_xref="InterPro:IPR006190" FT /db_xref="InterPro:IPR013132" FT /db_xref="InterPro:IPR013785" FT /db_xref="InterPro:IPR013974" FT /db_xref="InterPro:IPR020007" FT /db_xref="UniProtKB/TrEMBL:Q9F0M8" FT /protein_id="AAG43980.1" FT /translation="MKEIKIQNIIISEEKAPLVVPEIGINHNGSLELAKIMVDAAFSAG FT AKIIKHQTHIVEDEMSKAAKKVIPGNAKISIYEIMQKCALNYKDELALKEYTEKLGLVY FT LSTPFSRAGVNRLEDMGVSAFKIGSGECNNYPLIKHIAAFKKPMIVSTGMNSIESIKPT FT VKILLDNEIPFVLMHTTNLYPTPHNLVRLNAMLELKKEFSCMVGLSDHTTDNLACLGAV FT ALGACVLERHFTDSMHRSGPDIVCSMDTQALKELIIQSEQMAIMRGNNESKKAAKQEQV FT TIDFAFASVVSIKDIKKGEVLSMDNIWVKRPGLGGISASEFENILGKKALRDIENDTQL FT SYEDFT" FT CDS 8021..9079 FT /codon_start=1 FT /transl_table=11 FT /product="sialic acid biosynthesis protein" FT /note="ORF-09; similar to SiaA from Neisseria meningitidis" FT /db_xref="GOA:Q9F0M7" FT /db_xref="InterPro:IPR003331" FT /db_xref="InterPro:IPR020004" FT /db_xref="UniProtKB/TrEMBL:Q9F0M7" FT /protein_id="AAG43981.1" FT /translation="MYRVQNSSEFELYIFATGMHLSKNFGYTVKELYKNGFKNIYEFIN FT YDKYYQTDKALATTIDGFSRYVNELKPDLIVVHGDRIEPLAAAIVGALNNILVAHIEGG FT EISGTIDDSLRHAISKLAHIHLVNDEFAKRRLMQLGEDEKSIFIIGSPDLELLNDNKIS FT LSEAKKYYDINYENYALLMFHPVTTEITSIKNQADNLVKALIQSNKNYIVIYPNNDLGF FT ELILQSYEELKNNPRFKLFPSLRFEYFITLLKNADFIIGNSSCILKEALYLKTAGILVG FT SRQNGRLGNENTLKVNANSDEILKAINTIHKKQDLFSAKLEILDSSKLFFEYLLSGEFF FT KLNTQKVFKDIK" FT CDS 9076..9741 FT /codon_start=1 FT /transl_table=11 FT /product="CMP-sialic acid synthetase" FT /note="ORF-10; similar to NeuA from Haemophilus ducreyi" FT /db_xref="GOA:Q9F0M6" FT /db_xref="HSSP:1EYR" FT /db_xref="InterPro:IPR003329" FT /db_xref="UniProtKB/TrEMBL:Q9F0M6" FT /protein_id="AAG43982.1" FT /translation="MSLAIIPARGGSKGIKNKNLVLLNNKPLIYYTIKAALNTKSISKV FT VVSSDSDEILNYAKSQNVDILKRPISLAQDDTTSDKVLLHALKFYKDYEDVVFLQPTSP FT LRTNIHIDEAFNLYKNSNANALISVSECDNKILKAFVCNDYGDLAGICNDEYPFIPRQK FT LPKTYMSNGAIYILKIKEFLNNPSFLQNKTKHFLMDESSSLDIDCLEDLKKVEQIWKK" FT CDS 9729..10562 FT /codon_start=1 FT /transl_table=11 FT /product="acetyltransferase" FT /note="ORF-11; similar to putative ORF from Rhodobacter FT capsulatus encoded by Genbank Accession Number AF010496" FT /db_xref="GOA:Q9F0M5" FT /db_xref="HSSP:1MR9" FT /db_xref="InterPro:IPR011004" FT /db_xref="UniProtKB/TrEMBL:Q9F0M5" FT /protein_id="AAG43983.1" FT /translation="MEKITLKCNKNILNLLKQYNIYTKTYIENPRRFSRLKTKDFITIP FT LENNQLESVAGLGIEEYYAFKFSNILHEMGSFSFSGSFLPHYAKVGRYCSIADGVSMFN FT FQHPMDRISTASFTYETNHSFINNACQNHINKTFPIVNHNPSSSITHLIIQDDVWIGKD FT VLLKQGITLGTGCVIGQRAVVTKDVPPYAIVAGIPAKIIKYRFNKKTIERLLKIQWWKY FT HFADFYDIDLNLKINQYLDLLEEKIIKKSISYYNPNKLYFRDILELKSKKIFNLF" FT CDS complement(10554..11366) FT /codon_start=1 FT /transl_table=11 FT /product="glycosyltransferase" FT /note="ORF-12; similar to putative ORF HI0868 from FT Haemophilus influenzae encoded by GenBank Accession Number FT U32768" FT /db_xref="GOA:Q9F0M4" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:Q9F0M4" FT /protein_id="AAG43984.1" FT /translation="MPQLSIIIPLFNSCDFILRALQSCINQTLKDIEILIINDKSKDNS FT LNMVLEFAKKDPRIKIFQNEENLGTFASRNLGVLHSSSDFIIFLDSDDFLTLDACEIAF FT KEMKKGFDLLCFDAFVHRVKTKQFYRFKQDEVFNQKEFLEFLSKQRHFCWSVWTKCFKK FT DIILKSFEKIKIDERLSYGEDVLFCYIYFMFCEKIAVFKTCIYHYEFNPNGRYENKNKE FT ILNQNYHDKKKSNEIIKKLSKEFAHDEFHQKLFEVLKREEVGVKNRLK" FT CDS 11347..>11474 FT /codon_start=1 FT /transl_table=11 FT /product="heptosyltransferase II" FT /note="ORF-13; similar to RfaF from Helicobacter pylori" FT /db_xref="GOA:Q7BN90" FT /db_xref="UniProtKB/TrEMBL:Q7BN90" FT /protein_id="AAG43985.1" FT /translation="MIESCGIFFLNFVKIIKTILSKFRKFMKIFIHLPTWLGDTVMA" XX SQ Sequence 11474 BP; 4495 A; 1496 C; 1620 G; 3863 T; 0 other; aaagaatacg aatttgctaa agaggtttta aatcttagtg gtattgatga aacacatata 60 gaattagcac caaaatttag ccttgaagag ttaatggctt ttacaaaaat gatggatctt 120 atcataggaa atgatagtgg tccaacacat ttggcttttg ctttaaataa agcatctatt 180 acgatttttg gtgcaacacc aagctaccgc aatgcttttc aaactcatat caataaaatc 240 attgatgcag gtaaaaaaat ccaaaatgcc aagcatatcg ataaaagcga tttttgtatc 300 acgcgtatag aagaagaaga tatcttcaaa cttgccaaag gcttacttaa tgaaaaatag 360 tgatagaata tatcttagtc tttattatat tttgaaattt tttgttactt ttatgcctga 420 gtgtatcttg cattttttag ctttgattgt agcaagaatc actttttatc ttaacaaaaa 480 acatcgcaag atcatcgata taaatttaca aatctgcttc cctcaataca ctcaaaaaga 540 acgcgataaa ttgtctttga aaatttatga aaattttgct caatttggaa ttgattgttt 600 gcaaaatcaa aacaccacca aagaaaaaat tctcaataaa gtgaatttta tcaatgaaaa 660 tttacttata gacgctctag ctttaaagcg tcctattatc ttcacaactg cacactatgg 720 aaactgggaa attttaagcc ttgcttatgc ggctaaatat ggtgcgattt ccatagtggg 780 aaaaaagtta aaaagtgaaa ttatgtatga aattttaagc caaaatcgta ctcaatttga 840 catagagctt attgacaaaa aaggcggtat aagacaaatg ctaagtgccc taaaaaaagg 900 gcgagctttg ggaattttaa ctgatcaaga ctgcgtagaa aaagaaagtg taagattaaa 960 attttttaac aaagaagtga attatcaaat gggagcaagc cttatcgcac aaagaagcaa 1020 tgctttgatc atccctgttt atgcctataa agaaggtggt aaattttgca tagagttttt 1080 taaagcaaaa gattctcaaa atgcaagttt agaagaactg acactttatc aagcacaaag 1140 ttgcgaagaa atgattaaaa aaagaccttg ggaatacttt ttttttcata gacgctttgc 1200 tagttataat gaggaaattt acaagggtgc aaaatgaatc taaagcaaat aagcgttatt 1260 atcatcgtaa aaaatgctga gcaaactttg cttgagtgtt taaattcttt aaaagatttt 1320 gatgaaatta ttttacttaa caatgaaagc attgataata ccctaaatat agctaataaa 1380 tttaaaaaag attttgctaa tttatatatt tatcacaatg cttttatagg ttttggagct 1440 ttaaaaaatc ttgctttaag ttatgcaaaa aatgattgga ttttaagcat tgatgctgat 1500 gaagtgcttg aaaatgagtg tattaaagag cttaaaaatt taaaacttca agaagataat 1560 atcatcgcac ttagccgtaa aaatctctat aaaggcgaat ggataaaggc atgtggttgg 1620 tggcctgatt atgttttgag aatttttaat aaaaatttca ctcgttttaa tgataattta 1680 gtacatgaaa gccttgtttt gccaagtaat gctaaaaaaa tttatcttaa aaatggattg 1740 aagcattatt cttataagga tatctctcac ttaattgaca aaatgcagta ctactcaagt 1800 ctttgggcaa aacaaaatat acacaaaaaa agtggtgttt taaaagcaaa tttaagagct 1860 ttttggactt tttttagaaa ttatttttta aaaaatggct ttttatatgg ttataagggt 1920 tttataatta gcgtttgttc tgcattggga acatttttta aatatatgaa attatatgaa 1980 cttcaaagac aaaaaccaaa aacttgcgct ttaataataa taacttataa tcaaaaagaa 2040 cgccttaaac tagtgcttga tagtgttaaa aatctagcct ttttacccaa tgaagtttta 2100 atcgcagatg atggtagcaa agaagataca gcaaggctta ttgaagaata tcaaaaagat 2160 tttccttgtc ctttaaaaca catttggcaa gaagatgaag ggtttaaact tagtaaaagt 2220 cgcaacaaaa ctataaaaaa cgctgatagt gaatatataa tagttattga tggtgatatg 2280 attttggaaa aagatttcat aaaagaacat ttagaatttg cacaaagaaa gcttttttta 2340 caaggttcaa gagtaatttt aaataaaaaa gaaagcgaag aaattttaaa caaagatgat 2400 tatcgcataa tttttaataa aaaagatttt aaaagttcta aaaattcttt tttagctaaa 2460 atattttaca gtctttcaaa aaaaagatga aaaaatcttt taaaaaacca ctcttattaa 2520 aggtattagg ggttgcaata tgagtttttt taaaactgat tttgatgaac ttgatggttt 2580 taatgaaaat tttattggtt ggggtagaga agatagtgaa tttgttgcta gatttttatt 2640 taataaaggc atttttagac gattaaaatt taaagctatt gcttatcata tttatcacaa 2700 agaaaatagc aaaaaaatgc ttgaaagcaa tcatcaaatt tatttagata ccatcaaaaa 2760 taaaaagatt tcttggagat aaaacatgaa gaaaataggt gtagttatac caatctataa 2820 tgtagaaaaa tatttaagag aatgtttaga tagcgttatc aatcaaactt atactaactt 2880 agaaatcata cttgtcaatg atggtagcac agatgaacac tcactcaata ttgcaaaaga 2940 atatacctta aaagataaaa gaataactct ttttgataag aaaaatgggg gtttaagttc 3000 agctagaaat ataggtatag aatactttag cggggaatat aaattaaaaa acaaaactca 3060 acatataaaa gaaaattctt taatagaatt tcaattggat ggtaataatc cttataatat 3120 atataaagca tataaaagct ctcaagcttt taataatgaa aaagatttaa ccaattttac 3180 ttaccctagt atagattata ttatattctt agatagtgat aattattgga aactaaactg 3240 catagaagaa tgcgttataa gaatgaaaaa tgtggatgta ttgtggtttg accatgattg 3300 cacctatgaa gacaatataa aaaataagca caaaaaaaca aggatggaaa tttttgattt 3360 taaaaaagaa tgtataatca ctccaaaaga atatgcaaat cgagcattaa gtgtaggatc 3420 tagagatatt tcttttggat ggaatggaat gattgatttt aattttttaa agcaaattaa 3480 acttaaattt ataaatttta ttatcaatga agatatacac tttgggataa ttttgtttgc 3540 tagtgctaat aaaatttatg ttttatcaca aaagttgtat ttgtgtcgtt taagagcaaa 3600 cagtatatca aatcatgata agaagattac aaaagcaaat gtgtcagagt attttaaaga 3660 tatatatgaa actttcgggg aaaacgctaa ggaagcaaaa aattatttaa aagcagcaag 3720 cagggttata actgctttaa aattgataga attttttaaa gatcaaaaaa acgaaaatgc 3780 acttgctata aaagaaacat ttttaccttg ctatgccaaa aaagctttaa tgattaaaaa 3840 atttaaaaaa gatcctttaa atttaaagga acaattagtt ttaattaaac cttttattca 3900 aacaaaactt ccttatgata tttggaaatt ttggcaaaaa ataaaaaata tttaataata 3960 aaaatataaa aaattaatta atttttaggt ataatcacta taattatagg agaaaatatt 4020 ttatatgcta tttcaatcat actttgtgaa aataatttgc ttattcatcc cttttagaaa 4080 aattagacat aaaataaaaa aaacattttt actaaaaaac atacaacgag ataaaatcga 4140 ttcttattta ccaaaaaaaa ctcttgtgca aattaataaa tacaacaatg aagatttaat 4200 taaacttaat aaagctatta tacgggaggg gcataaagga tattttaatt atgatgaaaa 4260 atctaaagat ccaaaatctc ctttgaatcc ttgggctttt atacgagtaa aaaatgaagc 4320 tattacctta aaagcttctc ttgaaagcat attgcctgct atccaaagag gtgttatagg 4380 atataatgat tgtaccgatg gaagtgaaga aataattcta gaattttgca aacaatatcc 4440 ttcatttata ccaataaaat atccttatga aattcaaatt caaaacccaa aatcagaaga 4500 aaataaactc tatagctatt ataattatgt tgcaagtttt ataccaaaag atgagtggct 4560 tataaaaata gatgtggatc atatctatga tgctaaaaaa ctttataaaa gcttctatat 4620 accaaaaaac aaatatgatg tagttagtta ttcaagggtt gatattcact attttaatga 4680 taattttttt ctttgtaaag ataataatgg caatatattg aaagaaccag gagattgctt 4740 gcttatcaat aattataact taaaatggaa agaagtatta attgacagaa tcaataacaa 4800 ttggaaaaaa gcaacaaaac aaagtttttc ttcaaatata cactctttag agcaattaaa 4860 gtataaacac aggatattat ttcacactga attaaataat tatcattttc cttttttaaa 4920 aaaacataga gctcaagata tttataaata taattggata agtattgaag aatttaaaaa 4980 attctattta caaaatatta atcataaaat agaaccttct atgatttcaa aagaaactct 5040 aaaaaaaata ttcttaacat tgttttaaaa attttttata tttaaataaa atttttaaag 5100 ttaaaatatt tattttagct aacaatgtaa ccattaattt tgttcttttt attttatata 5160 tttgaatata tagcaaatat ttaattagca catagagaac gctacaatac ttgtttaaaa 5220 tataattttg ccttaaatag tttaaaacca actgcaactc ttgaatatta tttttaacaa 5280 gcacttcatt cttagtatta caaattgaat tattattagg cacgtaatga tataaattac 5340 agttcatata tgctattttt tgagcttgac ttaacattgg ataatataac aatacatctt 5400 cagccatatt gattttaaca tctttctcga gttttaaact cgcaaaagct tctaaataca 5460 atttctttct tataagtttc ccccacatag tccaatataa atttttcttt gcaataattt 5520 ttttcacaaa ctcttttttg ctataaaaac cagaattaaa gtcaaacttt ttatatgaaa 5580 taacattact ttcaacaata gcattgaaaa acactaaatc aacttcatcc tgttcatcta 5640 aaatttttat acactcttca caagcattta gttccaaata atcatcagga tctaaaaaca 5700 ttatataagg agagtttgct actttcacac cttcatatct tgctcttaaa agacctaagt 5760 ttttttcatt gtggattatt tttattcttt tgtctttttt agagtattct ttggctatat 5820 ttatactatt atcatttcca caatcatcaa ctacaattat ttctatatct ttaaaagtct 5880 gattgataca gctttctatt gcccttgcta tatattgttc cacattataa gttggtaaga 5940 tgattgaaat tttaaacata tttattcctt attttattat aatttaatta taacataaaa 6000 tctattttga taaaatcgtt aaaaataaat cttgatggaa aataatcatg aaaaaagtta 6060 ttattgctgg aaatggacca agtttaaaag aaattgatta ttcaaggcta ccaaatgatt 6120 ttgatgtatt tagatgtaat caattttatt ttgaagataa atactatctt ggtaaaaaat 6180 gcaaagcagt gttttacacc cctggtttct tctttgagca atactacact ttaaaacatt 6240 taatccaaaa tcaagaatat gagaccgaac taattatgtg ttctaattac aaccaagctc 6300 atctagaaaa tgaaaatttt gtaaaaactt tttacgatta ttttcctgat gctcatttgg 6360 gatatgattt ttttaaacaa cttaaagaat ttaatgctta ttttaaattt cacgaaattt 6420 atttcaatca aagaattacc tcaggggtct atatgtgtgc agtagccata gccctaggat 6480 acaaagaaat ttatctttcg ggaattgatt tttatcaaaa tgggtcatct tatgcttttg 6540 ataccaaaca agaaaatctt ttaaaactag cccctgattt taaaaatgat cgctcacact 6600 atatcggaca tagtaaaaat acagatataa aagctttaga atttctagaa aaaacttaca 6660 aaataaaact atattgctta tgtcctaaca gtcttttagc aaattttata gaactagcgc 6720 caaatttaaa ttcaaatttt atcatacaag aaaaaaataa ctacactaaa gatatactca 6780 taccttctag tgaggcttat ggaaaatttt caaaaaatat taattttaaa aaaataaaaa 6840 ttaaagaaaa tgtttattac aagttgataa aagatctatt aagattacct agtgatataa 6900 agcattattt caaaggaaaa taaatgaaag aaataaaaat tcaaaatata atcataagtg 6960 aagaaaaagc acccttagtc gtacctgaaa taggcattaa tcataatggt agtttagaac 7020 tagctaaaat tatggtagat gcagccttta gcgcaggtgc taagattata aagcatcaaa 7080 cccacatcgt tgaagatgag atgagtaaag ccgctaaaaa agtaattcct ggtaatgcaa 7140 aaataagcat ttatgagatt atgcaaaaat gtgctttgaa ttataaagat gagctagcac 7200 ttaaagaata cacagaaaaa ttaggtcttg tttatcttag cacacctttt tctcgtgcag 7260 gtgtaaaccg cttagaagat atgggagtta gtgcttttaa gattggttca ggtgagtgta 7320 ataattatcc gcttattaaa cacatagcag cctttaaaaa gcctatgata gttagcacag 7380 ggatgaatag tattgaaagt ataaaaccaa ctgtaaaaat cttattagac aatgaaattc 7440 cctttgtttt aatgcacaca accaatcttt acccaacccc gcataatctt gtaagattaa 7500 acgctatgct tgaattaaaa aaagaatttt cttgtatggt aggcttaagc gaccacacaa 7560 cagataatct tgcgtgttta ggtgcggttg cacttggtgc ttgtgtgctt gaaagacatt 7620 ttactgatag tatgcataga agtggccctg atatagtttg ttctatggat acacaggctt 7680 taaaagagct tattatacaa agtgagcaaa tggctataat gagaggaaat aatgaaagta 7740 aaaaagcagc taagcaagag caagtcacaa ttgattttgc ctttgcaagc gtagttagta 7800 ttaaagatat taaaaaaggc gaagttttat ctatggataa tatttgggtt aaaagacctg 7860 gacttggtgg aattagtgcg tctgaatttg aaaatatttt aggcaaaaaa gcattaagag 7920 atatagaaaa tgatacccag ttaagctatg aggattttac gtgaaaaaaa tcctttttat 7980 aacaggcact agggctgatt attctaagat taaatcttta atgtacaggg tgcaaaactc 8040 aagtgaattt gagctttaca tctttgcaac aggaatgcac ttaagcaaaa attttggcta 8100 tacagttaaa gagctttata aaaatggctt taaaaatatt tatgaattta taaattatga 8160 taaatattat caaaccgata aggctttagc cactacaatt gatggatttt caaggtatgt 8220 aaatgagcta aaacctgatt taatcgtagt acatggagat agaatcgagc ctttagcagc 8280 agctattgtt ggagcattaa ataatatctt agtagcgcat attgaaggcg gagagatttc 8340 aggaactatt gacgatagct tacgccacgc tatatcaaaa ctagctcata ttcatttagt 8400 aaatgatgag tttgcaaaaa ggcgtttaat gcagcttgga gaagatgaaa aatctatttt 8460 tatcataggt tcgcctgatt tagaactttt aaacgataat aaaatttcac ttagcgaagc 8520 aaaaaaatat tatgatataa attatgaaaa ctacgctttg cttatgtttc atcctgttac 8580 aactgaaatt actagcatta aaaatcaagc agataattta gtaaaagcac tgatacaaag 8640 taacaaaaat tatattgtta tttatccaaa taatgattta ggttttgaat taatcttgca 8700 aagctatgaa gagcttaaaa ataaccctag atttaagctt tttccatcgc ttagatttga 8760 gtattttata actttgttaa aaaatgctga ttttataata ggtaattcaa gttgtatttt 8820 aaaagaggcc ttatacttaa aaacagcagg aattttagtt ggctcaaggc aaaatggaag 8880 acttggcaat gaaaatacac taaaagttaa tgcaaatagt gatgaaatac taaaagctat 8940 taataccatt cataaaaaac aagatttatt tagcgccaag ttagagattt tagatagctc 9000 aaaattattt tttgaatatt tattaagcgg agaatttttt aaacttaaca cacaaaaagt 9060 ttttaaggat ataaaatgag cttagcaata atccctgctc gtggtggctc aaagggtatt 9120 aaaaataaaa atttggtttt attaaacaat aaacctttaa tttattacac cattaaagct 9180 gcactaaata ctaaaagcat tagtaaagtt gttgtaagca gtgatagtga tgaaatttta 9240 aattatgcaa aaagtcaaaa tgttgatatt ttaaaacgcc caattagcct tgcacaagat 9300 gataccacaa gcgataaagt gctgttacat gctctaaaat tttataaaga ttatgaagat 9360 gtagtttttt tacaacccac ttcgccgcta agaacaaata ttcatattga tgaagctttt 9420 aatctttata aaaatagcaa tgcaaatgcc ctaattagcg taagcgaatg tgataataaa 9480 attctaaaag cctttgtttg taatgattat ggcgatttag cagggatttg taatgatgaa 9540 tatcctttta taccaaggca aaaattgcct aaaacatata tgagcaatgg tgcaatttat 9600 attttaaaga taaaagaatt tttaaacaat cctagctttt tgcaaaacaa aaccaagcat 9660 tttttaatgg acgaaagctc aagtttagat attgactgtt tggaggattt aaaaaaggtt 9720 gaacagatat ggaaaaaata accttaaaat gcaataaaaa tatattaaat ttattaaagc 9780 aatataatat ttatacaaaa acttacatag aaaatcctag aagattttca agactaaaaa 9840 ccaaagattt tataaccatt ccattggaaa acaatcaatt agagagtgtg gctgggctgg 9900 ggatagaaga atattatgct tttaaattta gcaatatctt acatgaaatg ggttcatttt 9960 cttttagcgg atcttttcta cctcattatg caaaagttgg aaggtattgt tcaattgctg 10020 atggggtttc tatgtttaac tttcaacacc ctatggatag aatcagcact gcaagtttta 10080 cctatgaaac aaatcatagt tttattaaca atgcttgtca aaatcacatc aacaaaacat 10140 ttcctatagt taaccataat ccaagctcat caataacgca tttaattata caagatgatg 10200 tttggatagg aaaagatgtt ttgcttaaac agggtatcac acttgggact ggatgtgtca 10260 taggacaaag agctgtagtt actaaagatg taccacctta tgctatagtt gcaggaattc 10320 cagccaaaat tatcaaatat agatttaata aaaaaacaat agaaagatta ttaaaaattc 10380 aatggtggaa atatcatttt gctgattttt atgatattga tcttaattta aaaataaacc 10440 aatatcttga cctactagaa gaaaaaatca taaaaaaatc aatttcctac tataatccaa 10500 ataaacttta ttttagagat attttagaac taaaatcaaa aaaaattttt aatctatttt 10560 aatctatttt tcacccctac ttcctctctc tttaaaactt caaataattt ctgatgaaat 10620 tcatcatgtg caaactcttt ggatagtttt tttatgattt cattactttt ctttttatca 10680 tgataatttt gatttaaaat ttctttattt ttattctcat atcttccatt tggattaaat 10740 tcataatgat aaatgcaagt tttaaaaaca gctattttct cacaaaacat aaaataaata 10800 taacaaaaaa gcacatcttc gccgtaactc aaacgctcat ctattttaat tttttcaaaa 10860 ctttttaaga tgatatcttt tttaaagcac ttcgtccaaa ccgaccagca aaaatgcctt 10920 tgtttactta aaaattctaa aaattccttt tgattaaaaa cttcatcttg tttaaaacga 10980 taaaattgtt tggtttttac cctatgcaca aaggcatcaa aacaaagcaa atcaaaacct 11040 tttttcatct ctttaaacgc tatttcacaa gcatcaagtg ttaaaaaatc atcactatct 11100 aaaaatatta taaaatcaga actagaatgc aaaaccccca aatttctact tgcaaaagtg 11160 cctaaatttt cttcattttg aaagattttt atccttggat cttttttagc aaattctaaa 11220 accatattta aactattatc tttactttta tcattgatga tcaaaatttc aatatctttt 11280 aaagtctgat ttatacaact ttgtaaagct cttaagataa aatcacaaga attaaaaagc 11340 gggattatga tcgaaagttg tggcatattt ttcctaaatt ttgttaaaat aataaaaaca 11400 attctatcaa agtttaggaa atttatgaaa atttttatac accttcccac ctggttaggc 11460 gatacggtaa tggc 11474 // |
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