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EBI DbfetchID AF205580; SV 1; linear; genomic DNA; STD; INV; 6598 BP. XX AC AF205580; L22057; XX DT 07-SEP-2000 (Rel. 65, Created) DT 07-SEP-2000 (Rel. 65, Last updated, Version 1) XX DE Plasmodium falciparum ribonucleotide reductase large subunit (R1) gene, DE promoter and complete cds. XX KW . XX OS Plasmodium falciparum (malaria parasite P. falciparum) OC Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodium; OC Plasmodium (Laverania). XX RN [1] RP 3932-6598 RX DOI; 10.1073/pnas.90.20.9280 RX PUBMED; 8415692. RA Rubin H., Salem J.S., Li L.S., Yang F.D., Mama S., Wang Z.M., Fisher A., RA Hamann C.S., Cooperman B.S.; RT "Cloning, sequence determination, and regulation of the ribonucleotide RT reductase subunits from Plasmodium falciparum: a target for antimalarial RT therapy"; RL Proc. Natl. Acad. Sci. U.S.A. 90(20):9280-9284(1993). XX RN [2] RP 1-6598 RA Leete T.H.; RT "Cloning and Analysis of the Ribonucleotide Reductase Subunit Gene RT Promoters from Plasmodium falciparum"; RL Unpublished. XX RN [3] RP 3932-6598 RA Rubin H.; RT ; RL Submitted (20-AUG-1993) to the EMBL/GenBank/DDBJ databases. RL Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, RL USA XX RN [4] RC Sequence updated by submitter RP 1-6598 RA Leete T.H., Rubin H.; RT ; RL Submitted (16-NOV-1999) to the EMBL/GenBank/DDBJ databases. RL Medicine, University of Pennsylvania, 536 Johnson Pavillion, 36th St. and RL Hamilton Walk, Philadelphia, PA 19104, USA XX CC On Sep 6, 2000 this sequence version replaced gi:349791. XX FH Key Location/Qualifiers FH FT source 1..6598 FT /organism="Plasmodium falciparum" FT /chromosome="14" FT /mol_type="genomic DNA" FT /country="Gambia" FT /clone="FCR3-A2" FT /db_xref="taxon:5833" FT promoter 1..1022 FT /gene="R1" FT protein_bind complement(118..124) FT /bound_moiety="AP-1" FT /note="putative" FT mRNA join(1023..6107,6293..>6598) FT /gene="R1" FT /product="ribonucleotide reductase large subunit" FT misc_feature 1285..1292 FT /gene="R1" FT /note="putative octamer binding site" FT protein_bind complement(3391..3397) FT /bound_moiety="AP-1" FT /note="putative" FT CDS join(3999..6107,6293..6598) FT /codon_start=1 FT /gene="R1" FT /product="ribonucleotide reductase large subunit" FT /db_xref="GOA:P50647" FT /db_xref="InterPro:IPR000788" FT /db_xref="InterPro:IPR005144" FT /db_xref="InterPro:IPR008926" FT /db_xref="InterPro:IPR013346" FT /db_xref="InterPro:IPR013509" FT /db_xref="UniProtKB/Swiss-Prot:P50647" FT /protein_id="AAA29755.1" FT /translation="MYVLNRKGEEEDISFDQILKRIQRLSYGLHKLGEYPACVTQGVIN FT GMYSSIKTCELDELAAQTCAYMATTHPDFSILAARITTDNLHKNTSDDVAEVAEALYTY FT KDGRGRPASLISKEVYDFILLHKVRLNKEIDYTTHFNYDYFGFKTLERSYLLRINNKII FT ERPQHLLMRVSIGIHIDDIDKALETYHLMSQKYFTHATPTLFNSGTPRPQMSSCFLLSM FT KADSIEGIFETLKQCALISKTAGGIGVAVQDIRGQNSYIRGTNGISNGLVPMLRVFNDT FT ARYVDQGGGKRKGSYAVYIEPWHSDIFEFLDLRKNHGKEELRARDLFYAVWVPDLFMKR FT VKENKNWTLMCPNECPGLSETWGEEFEKLYTKYEEENMGKKTVLAQDLWFAILQSQIET FT GVPIYLYKDSCNAKPIKNLGTIKCSNLCCEIIEYTSPDEVAVCNLASIALCKFVDLEKK FT EFNFKKLYEITKIITRNLDKIIERNYYPVKEAKTSNTRHRPIGIGVQGLADTFMLLRYL FT YESDAAKELNKRIYETMYYAALEMSVDWLQSGPYESYQGSPGSQGILQFDMWNAKVDNK FT YWDWDELKLKIAKTGLRNLLLLAPMPTASTSQILGNNESFEPYTSNIYYRRVLSGEFFV FT VNPHLLKDLFDRGLWDEDMKQQLIAHNGSIQYISEIPDDLKELYKTVWEIKQKNIIDMA FT ADRGYFIDQSQSLNIYIQKPTFAKLSSMHFYGWEKGLKTGAYYLRTQAATDAIKFTVDT FT HVAKNAVKLKNADGVQITREVSRETIQLNQRYSKCVSFKSNNDEQCLMCSG" XX SQ Sequence 6598 BP; 2683 A; 540 C; 689 G; 2686 T; 0 other; agatctgtat aatatttata gaaagaaaag tacgacatcg tatgaaaata catatataaa 60 ttagagcttt aaaaattaaa aataaaaaaa tatatatata tatatattta tatattatga 120 ctcaaatcat atttcatatt ttcaaaatgg aaaataagtt ttaaagcgta aataaaataa 180 ataaagaatg tttatttatt tatttattta ttatttcaaa agtataatta tataaagtct 240 ttgaagacta cacaaattag cattataaaa aaaataaaag atatacaaac atatatgtgc 300 acatttatct gcttttctta tttttatact ttttaaatat aaatatattt taaaatatat 360 acattattta aaaatatttg aacatatgaa tatattacat atatatgtat atatattttt 420 atttgtttta aatttttaat tgctttagat atttatttaa atttataata attttataaa 480 tttaataatt tcatgtatat ataacatatt attgttatta tattttatta tttatttatt 540 tatttatttt tttttttttg tatacgaatg aaacaacgac gggaaaaaaa aaaaaaaaaa 600 aaaaaaaaat tgttttttgc ttcttatttt attttattta tatatttctt taaattttta 660 acagtttttt aatttctttt tttttctttt attataaatt tttgccattc catatttata 720 attttgaatt aacattttaa taatttacaa ttttgtagaa tatatatata tatatatata 780 tatttataga tgactttata tatatataga aatttttgta atatgaactt aataggtgat 840 ctaatttttt ttttttttat aatttatttg ttttatttaa tttttctttt cctttttttc 900 tttctttttt tttttttctt ttttgtacaa tcatattcct tttttaaaat aaaagaaaag 960 gaaattatat atatatatat ataataatta tattttaata tgaaactata tattttttta 1020 gtaccacaaa taacagatgt ttatattttt tacatatata taaaatttat atataataaa 1080 ttatatttat aaatcaatca tatttttatt ttatttttac cattaggtat tatatatata 1140 tatatatata tatatatata tatatatatt tatatttata ttcatatata taattccctt 1200 acatgtttgt atttttttat ttgaaatatt tatttgtaca tatacacact taaatatgtt 1260 tattcagtag atttttcttt gcctatgcaa atggtgtaat ttgtatatat agtaaagcta 1320 tttgaaatac atttattaaa ttataaagtt atataatatt aagaaaaaaa atgtttttaa 1380 atatatagta tataagcatt ttatacacat atatatatat atatatataa ctaaatatat 1440 aacattataa ttttgtcatt tttaatttga tcagaaactt ataactgttt ttttacttta 1500 ttattttata tcttttatag gtgtaaaata taaatatata aatacatata tatatatatt 1560 atattatgtt tatttattta ttaatgtagt atacaccttt gtaattaata atattttgca 1620 ttcatatata tatacatata aacatatata tgtatatata ataatattgt gtacacaata 1680 atttgtcaaa tcatatatat ttatatatat atttcatttt ttcctttttt tttgttaaac 1740 aaataatact tgtccaaaag aaaaaaaaaa aaaatggaaa aatatatatt ttttttaaaa 1800 tacacaattg ttccttttgt gctaaatttt tattaataat atgattttat taaatataaa 1860 atttacacct tataaaatta tataaataac attttatata tttataatat attgcttata 1920 taataatata ccactttgat atatttgcaa aattgttatt atgtatgcat tattataaaa 1980 aaaaaaaaaa aaaaattata tatgtattat gtatattata tatatatata tataataata 2040 ataataatac aagttatgta atgtatatta ccttatagta tcttttatta gatatgtaaa 2100 tattcatata ttgttactat ttgaacacac ttgcatattt tcatataaat atatgatttt 2160 attttatttt tatcctattc atttaacaca tgtatatata tatatatata tatatatata 2220 tatatatgtt attattatgt acacattaat attttttttt ttttttttaa atatattttt 2280 tttgttttaa cacataatta tataatcttt ctttttcatt ttaaatatat atatatatat 2340 atataatata tattttatat tttcagaata taaataatgt gaatttttat atatcatttg 2400 ttatgtacat aattattcat aaaaatttat atacattaat atattatata aaaaatgata 2460 aaaaaaaaaa ataaaaccct tctaagataa gtatacttaa gatatattgt tcatgaaatt 2520 gtccatgaag aaaaaaatat atattgtatt tttaagttta aaataatttt ttaaattcct 2580 ttcattttta aatttttatc aaaatacaaa aatatatgaa aaaaatgaga tattaaaata 2640 aatagaatat atttatagtt cttaatatta attattttat ttattcattt cattttattt 2700 tattttattt ttttattttt tttttttatt ttatttttct tttttgtttg catgattttg 2760 ttaaatatat tattattatt aattatgtat ataatatgtt tagaatttta tattattttc 2820 tagaaagata tatataattc tgttatttta taacttaatt aatttgtctt ttctctatta 2880 ttatatttgt gtacattttt tcttaaatta ttaatttaat ttattgtcat actataaata 2940 atattatcaa aatattacac tgaataatga agtatatata atttttttaa ttatccaaaa 3000 tattattata atataaatat atttgtattt atacatgtta aaaatatgtt attattttaa 3060 aagaaaaact ttgttatata aattatatat atatatatat atatatatat atttatttat 3120 ttatttattt atttatttac atttgtaaat atataatttt ttttattttt tattcaaata 3180 agatattaaa aaatatatat atttgtatac atatttttat atatctatgt attttgtttt 3240 ttttatatta atcatataga tattatacaa aataaagaga aaaaaataaa aaaaaattat 3300 cagaaaaagg aagaaataat tctgtctttc aatatatata tttataatat ataaagctta 3360 agtgtaaatt tttaatttgt ctaacttaat tgactaaaat atattttata tatatatata 3420 taattttata atattaaaca ttataaaatt agtggatagt tcaaaattta ttaaataata 3480 tataaacata tatatattat attttaccaa aaaaaaaaaa aaaaaaataa aataataaaa 3540 taaataaata gtaataataa taaataatat aataataata attgatttag aaagtataaa 3600 gagtaaagga caaagaaata taatacacac aagaatatat tggattttaa tttaaatgta 3660 aaataagaaa agaacttatt tatattttta aatattatat attaatgcat attatttaga 3720 aataaaaaat acatatatat atatatatat atatacatat atttaaataa taatatatat 3780 atatatatat atattagcat aaaaatacca gaattaaatt atatatttat aattatatta 3840 aaaaaataaa taaataaata aataaataaa aaagaatggg tgataatgta aaaagactac 3900 cattaccatc agagaatgga gaaattaaaa agagtacatc aggaagatta agtgatgatg 3960 gtattaagag aaccccatca ggtaaaccta tacaaacaat gtatgtgttg aatagaaagg 4020 gagaagaaga agatatatcc tttgatcaaa ttttaaaaag aatacaaagg ttatcatatg 4080 gtcttcataa attaggtgag tatcctgctt gtgttacaca aggtgtaatc aatgggatgt 4140 atagtagtat aaaaacctgt gaattagatg aattagctgc tcaaacatgt gcatatatgg 4200 ctacaacaca tcctgatttt tctatattag ctgcacgtat tactacagat aatttgcaca 4260 aaaatactag tgatgatgtt gcagaagtag ctgaagcatt gtatacgtat aaagatggta 4320 gaggtagacc agctagctta attagtaagg aagtatatga ttttatttta ttacataaag 4380 tacgtttaaa taaagaaata gattatacta cccattttaa ttatgattat tttggattta 4440 aaacattgga aagatcttat ttattacgta ttaataataa aattattgaa agacctcaac 4500 atttattaat gagagtttct attggtatac atatagatga catagataaa gctttagaaa 4560 catatcattt aatgtctcag aaatatttta cccatgcaac tcctacattg tttaattcag 4620 gaaccccaag gccacaaatg tcttcttgtt tcttgttatc aatgaaagca gattctattg 4680 aaggtatttt tgaaactcta aaacaatgtg ctttaattag taaaactgca ggaggtattg 4740 gtgtagcagt acaagatata agaggacaaa attcttatat tagaggtacc aatggaatat 4800 ctaatggttt agtacctatg ttaagagttt ttaatgatac tgcaagatat gtagatcaag 4860 gtggaggaaa acgtaaggga tcgtacgctg tttatattga accatggcat tcagatatat 4920 ttgaattttt agatttaaga aagaatcatg gaaaagaaga attaagagca cgagatttat 4980 tttatgctgt atgggttcct gatcttttta tgaagagagt taaagaaaat aaaaattgga 5040 cattaatgtg tccaaatgaa tgtccaggtt taagtgaaac ctggggtgaa gaatttgaaa 5100 aattatatac aaaatatgaa gaagaaaata tgggaaaaaa aactgtgctt gctcaagatt 5160 tatggtttgc tatattacaa agccaaatag aaacaggagt acccatatat ctatataaag 5220 attcttgtaa tgcaaaacca atcaaaaatt taggtacaat taaatgtagt aacttatgtt 5280 gtgaaataat cgaatatacc tctcctgatg aagttgctgt atgtaatttg gcatctatag 5340 ctttatgtaa atttgtagat ttggaaaaaa aagaattcaa tttcaaaaag ttatatgaaa 5400 taaccaaaat tattacaaga aatttagata aaattataga aagaaattat tatccagtca 5460 aagaagcaaa aacatctaat actagacata gacctattgg tattggtgtt caaggattag 5520 cagacacatt tatgttatta agatatcttt atgaatctga tgctgcaaaa gaattgaata 5580 aaagaatata tgaaactatg tattatgctg ctttagaaat gtcggttgat tggcttcaat 5640 ctggtccata tgaatcttat caaggaagtc caggtagcca aggtatatta caatttgata 5700 tgtggaatgc taaagttgat aacaaatatt gggattggga tgaattaaag ctaaagattg 5760 caaaaactgg tttaagaaac ctattattat tagcacctat gccaactgca tctacttcac 5820 aaattcttgg aaacaatgaa tcctttgaac catatactag taatatttat tatagaagag 5880 ttttaagtgg agaatttttc gttgttaatc ctcatttgtt aaaagattta tttgacagag 5940 gtttatggga tgaagacatg aaacagcaat taatagctca caatggaagt attcaatata 6000 taagtgaaat accagatgac ttgaaagagt tgtacaaaac tgtatgggaa attaagcaaa 6060 agaatattat tgatatggct gcagacaggg ggtattttat tgatcaggta aaattaaaat 6120 ataaaagata atatatataa atataaataa ataaataaat aaataaaaaa aaaaatatat 6180 atatatatat atatatatat atttatattt atagtgtatg tcatttgttt tataagtata 6240 tattttgttc atacatttat attcatatat attttttttc ctttttttat agtcccaatc 6300 attaaatatt tatattcaaa aaccaacctt tgcaaaattg tcaagtatgc atttctatgg 6360 atgggaaaaa ggattgaaaa cgggagctta ctatttaaga acccaagcag cgaccgatgc 6420 tattaaattt accgtcgata ctcatgttgc aaaaaatgct gtaaaactca aaaatgcaga 6480 tggagtacaa ataacaagag aagtttccag agaaacaatt caactgaatc aacgttactc 6540 aaaatgtgtg tcctttaaga gtaataatga tgaacaatgt ttaatgtgtt ctggttaa 6598 // |
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