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EBI DbfetchID AF102882; SV 1; linear; genomic DNA; STD; FUN; 8023 BP. XX AC AF102882; XX DT 03-FEB-1999 (Rel. 58, Created) DT 03-MAR-2000 (Rel. 62, Last updated, Version 2) XX DE Filobasidiella neoformans glucan synthase (FKS1) gene, complete cds. XX KW . XX OS Cryptococcus neoformans var. neoformans OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; OC Tremellales; Tremellaceae; Filobasidiella; OC Filobasidiella/Cryptococcus neoformans species complex. XX RN [1] RP 1-8023 RX PUBMED; 9882657. RA Thompson J.R., Douglas C.M., Li W., Jue C.K., Pramanik B., Yuan X., RA Rude T.H., Toffaletti D.L., Perfect J.R., Kurtz M.; RT "A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy RT and encodes an essential function"; RL J. Bacteriol. 181(2):444-453(1999). XX RN [2] RP 1-8023 RA Thompson J.R., Douglas C.M., Li W., Jue C.K., Pramanik B., Yuan X., RA Rude T.H., Toffaletti D.L., Perfect J.R., Kurtz M.; RT ; RL Submitted (30-OCT-1998) to the EMBL/GenBank/DDBJ databases. RL Department of Infectious Diseases, Merck Research Labs, PO Box 2000, RL Rahway, NJ 07065, USA XX FH Key Location/Qualifiers FH FT source 1..8023 FT /organism="Cryptococcus neoformans var. neoformans" FT /strain="H99" FT /mol_type="genomic DNA" FT /db_xref="taxon:40410" FT CDS join(1940..2012,2059..2921,2969..6027,6075..6627, FT 6682..6921,6976..7090,7144..7296,7352..7470) FT /codon_start=1 FT /gene="FKS1" FT /product="glucan synthase" FT /db_xref="GOA:O93927" FT /db_xref="InterPro:IPR003440" FT /db_xref="UniProtKB/TrEMBL:O93927" FT /protein_id="AAD11794.1" FT /translation="MGGRWEGGGMGRETWASESGWSQNEPNYPPSDYHGGPGYLPSRAS FT TPTFEGSNAGHRPRDPYPAWTVDANIPLSKEEIEDVLIDLANKFGFQKDSSRNVYDFLM FT IQLDSRASRMSPNQALLTLHADYIGGEHANYRKWYFAAQLDLDDAIGAVQNPGLNRVRS FT VARRGGKTKNPLATAQEKSLESATSRWRTAMNNMSQYDRLRQVALYLLCWGEAAQVRFM FT PECLCFIFKCADDYYRSPECQNRQEAVPEGLYLRAVIKPLYRFLRDQGYEVVDGKFLRR FT ERDHDKVIGYDDVNQLFWYPEGISRITLNDNTRLVDIPPAQRFMKFDRIDWNKVFFKTY FT LEKRSFFHLLVNFNRIWVLHISVFWFFTAYNAPSIYAPSGSTTATTPMAWSMTGLGGFV FT ATLIMIAATLAEFSYIPTTWNNTSHLTRRLIFLLIILAITGGPSIYIAFFNQTGHVALI FT LGIVQFFCSVVATIAFATLPSGRMFGDRVAGKSRKYLANQTFTASYPALGFYPRVASFL FT LWFLVFGCKFTESYFFLTLSFRDPMKVMNGMKVQNCHDKYFGNGLCTNQPAFALAVMFV FT MDLTLFFLDTFLWYVIWNTVFSIARSFAIGMSIWTPWKDIFARLPKRIYAKILATDDME FT VKYKPKVLVSQVWNAVIISMYREHLLSIEHVQKLLYHQIQSDQPGKRTLRAPAFFISQS FT EKGSKAEFFPKGSEAERRICFFAQSLTTSIPAPIPVDAMPTFTVLVPHYSEKILLSLRE FT IIREEDQNTRVTLLEYLKQLHPVEWDNFVRDTKILAEESDAFNGGNPFASDEKEEAKKA FT DDIPFYTIGFKSAAPEYTLRTRIWASLRAQTLYRTVSGFMNYSKAIKLLYRVENPEVVQ FT LFGGNTDQLERELERMARRKFKFVVSMQRYSKFNKEEHENAEFLLRAYPDLQIAYLDEE FT PPRKDGGESRIFSALIDGHSEIMPNGRRRPKFRIELPGNPILGDGKSDNQNHAIVFYRG FT EYLQLIDANQDNYLEECLKIRNVLGEFEEFKVSTQSPYAAQGHADFAKFPVAILGAREY FT IFSENIGILGDIAAGKEQTFGTLAARSLSYIGGKLHYGHPDFLNAIYMNTRGGVSKAQK FT GLHLNEDIFAGMLAFGRGGRIKHSEYYQCGKGRDLGFGTILNFQTKIGTGMGEQMLSRE FT YYYLGTQLPIDRFLTFYYGHPGFHINNILVMMSVQVFMLALVFLGTLNKQLTVCRYSSG FT GDILPGQSGCYNLVPVFKWIKRCIISIFIVFWMAFVPLFVQELTERGTGRAILRLCKHF FT LSLSPVFEVFSTQIYMHSILNDLTFGGARYIATGRGFATTRISFSILYSRFAGPSIYLG FT MRTLVLLLFITLTVWVPHLIYFWITVVGLCVAPFLFNPHQFAIADFIIDYREFLRWMSR FT GNSRTHANSWVGYCRLSRTRVTGFKRKRLGLPSEKLSSDVPRAPWKAILIGEIIGPICL FT AILFVICYLFIKSFAVDGQIQPGLVRIAIIALGPIVWNMALLITLFLISVFLGPCLNSY FT THQFGATMAALAHFGAVAGMLVFFELLWFLELWNTSHAVLGIIAVISVQRCIFKFLIAV FT FLSREFKHDETNRAWWTGVWFNRGLGSHALSQPAREFVVKTIEMGLYSADFIACHLLLA FT LLTIPMFIPYFDRVHATMLFWLAPNQQIRPPIYSFRQRSQRRKIVFKYGLLYLIIQGIF FT IALIVVPIIFKDVAGLTPKSVPFNGII" XX SQ Sequence 8023 BP; 1811 A; 2074 C; 1769 G; 2369 T; 0 other; ctgcagtgag ctccctgatt agcttttaca gggtcatacc atcccccaga agagtaatag 60 caaactacat tcaccggacc atattgggtt cattttgagc cgcacgctga ctaagacaac 120 caacggggac gccgaggaag ccggcacggt ggatcaatcg ttacgtgata agactggatg 180 tcatcttacc aagcagccaa atgcgcctta cgaagcagca gacgaatgtg tcttaccaag 240 cagccaaata gtttcttctc tgcctttact ttgatatttc gataattcag gcgcggattt 300 gcactacggt actggtttat caggtaatca accgaagctt ctttcgaatt tagggtacgt 360 tggctcgcga gagcgagttt gttgtatgtt ttgccttcta gcttcgatgg atgtaaagcg 420 agtggatact ttgatgccat gcttaccgtt ccatcgttcg tccttgttgg ttgagcgagg 480 aaggagtatg atggtattaa cccctcatca ttgtgcttgt agatgggagg gtgctaacaa 540 cagtccaggc agcaggtaca tagcaaaggt tctaaatggt ctactttcag ggacacttgt 600 ttttaagtct agtggaaagg gaaagtcgcg gttgccaagg aagtgatgga aacctgtgtt 660 ctgttgagac attggtcaaa gacttgtaaa tatgtttgtt gggatcgtga tggataatca 720 atgatattct ggctctgacc gcaactatgt aaaacgccac tgaaagtgga acacgcatga 780 caagtagtaa gtatacgtac aaaccgccgc cttgggtgta cacccgacgg ccaacaatgc 840 ctctactatt accccttttt gcccaacgtt ctgtcgacca ccccatgaca aaaatgccac 900 tctctaatcg ccgaaactcc gtggccaaaa gcgatgacct atgacgtatg acgctgttcc 960 tctttttcag ggtatccggc ccattttcaa atggctgggc caggaaaaaa atgatttccg 1020 gaagacttgc cccctcaaac gcgactttta cttcccaaaa cacggctgca ccctgaattc 1080 cttgaacgaa aacgtaaaac agtaactgcc tcgtgatttg agggtgcaat tttccgagcc 1140 gtccgttgtt gatgggtttg attagaagaa aattagaaaa tttacagatt ttctaatcat 1200 tccctctctt ttcttactat ttttcttaat cacattccta atctcagggt ttctctcacg 1260 cgtagtcgca aaggtctcgg gaaggcgaca gacatcgcct tcctcttcca cttctcatcc 1320 acaacttgta cttccaacta ttatttccta ctacattcac tctttactct cacgatcccg 1380 gacggagacg tctacagctt ccgacgcccg gtgtgacacg actgtacggc aacaccaaag 1440 actcgagcca agcgagcatc tctccaattt cagtgctgtg cagaagacgt gtagagctat 1500 cgacaggaag agaggtgtaa ctgtaactgt aggtgagtgg cgtttctaca aagtcgagga 1560 tccattgcaa tagtggttgc gaagacctgt gaatacgcta ccgtggtagc atttttcttc 1620 gcctgtgttg ttttaccgag cgcactggcg tcctttgttt taccacacaa cttttttaat 1680 tgtcagcgct gacttgagac tttctttagc gtcatgtcat atcccaatcc cccgccaccg 1740 ccgaaagggt ctgcttcctt tttcttcatc ctcttccgat cctttcaacc aaaccaacca 1800 acttccctac gactcccaat tcccccctca acatgctttc gcccatccca gtgcgccaaa 1860 tcctggtgcg ggtggtgctg gcgtagctcc tcccggacag gggggacagt atgctccgta 1920 ttatgacaat gaacctgaga tgggtggaag gtgggagggt ggcggtatgg gcagagagac 1980 ttgggcgagc gagagtggat ggagtcaaaa tggtgagttg tttgtatatg ggaagtgctg 2040 cggctgatca gatggtagaa cccaactatc ctccctcaga ttaccacgga ggtcccggtt 2100 acttgccgtc tcgagcgtcg actccaacct ttgaaggcag caacgcggga caccgacctc 2160 gtgaccctta ccccgcttgg actgttgatg ccaacatccc attgtccaag gaagagattg 2220 aggacgtttt gattgacctt gcaaacaagt ttggtttcca aaaggactct tctcgaaatg 2280 tctacgactt tctcatgatc caacttgact ctcgtgcttc tcgaatgtcc cctaaccaag 2340 ctcttcttac tctccacgcc gactacattg gtggtgaaca cgctaactac cgcaaatggt 2400 actttgctgc tcaactcgac ttggacgacg ctatcggtgc tgtgcagaac cctggtctta 2460 accgagtgcg ttcagttgcc cgacgtggcg gcaagaccaa gaaccctctc gctaccgccc 2520 aagaaaagtc tctcgaatct gccacctctc gttggcgaac ggctatgaac aatatgtctc 2580 agtacgatcg ccttcgtcaa gtcgctcttt acttgctttg ttggggtgaa gccgctcagg 2640 tcaggttcat gcccgaatgt ctttgtttca tctttaaatg tgcggatgat tactatcgat 2700 ctcccgaatg ccaaaacagg caagaagccg tccctgaggg tctgtatttg agggctgtta 2760 taaagcctct ttaccgattc ttgagggatc aggggtacga ggttgtggat ggcaagttct 2820 taagaagaga gagagatcat gataaggtta tcgggtatga cgatgtgaat cagttgttct 2880 ggtatcctga aggaatcagt cgaatcactt tgaatgacaa cgtgggtact tttgcttcat 2940 gctcgagcta tactgacttt ccatctagac ccgacttgtc gatattccac ctgctcagcg 3000 attcatgaag tttgacagaa tcgactggaa caaggttttc ttcaagacat accttgagaa 3060 gcgatccttc ttccatcttt tggtcaactt taaccgtatc tgggttctcc acatttccgt 3120 cttttggttc ttcaccgcat acaacgcccc ttctatttat gctccatccg gatcaacgac 3180 agcaacaacg ccaatggctt ggtctatgac gggtttaggt ggtttcgtcg ccactctcat 3240 catgattgct gccactctag ccgagtttag ctacatccct accacttgga acaacacttc 3300 tcaccttact cgtcgcctta tcttcctatt aattattctc gctataaccg gtggaccatc 3360 aatttatatc gcgttcttca atcagacagg tcatgttgca ttgattctcg gtatcgtcca 3420 attcttctgt tccgtcgtcg ccaccatcgc cttcgccact ctgccctctg gccgaatgtt 3480 tggtgaccgt gtggccggca agagcaggaa gtatcttgcg aaccaaactt tcaccgcgtc 3540 ttatcccgct ctcggcttct accctcgtgt ggcatctttc ctcctttggt tcctcgtttt 3600 cggctgcaag ttcaccgagt cctacttctt cttgactttg tctttccgtg acccaatgaa 3660 ggtcatgaac ggtatgaagg ttcagaactg tcacgataag tacttcggca atggtctgtg 3720 tacgaatcag cctgcttttg ccctcgctgt catgtttgtc atggacttga ctctgttctt 3780 cttggatacc tttttgtggt atgtcatttg gaacactgtc ttctctatcg ccagaagctt 3840 tgctatcggt atgagtatct ggaccccttg gaaggatatc ttcgccaggc tgcccaagag 3900 gatctatgcc aaaatccttg ctacggatga tatggaagtc aagtacaagc cgaaggtctt 3960 ggtctctcaa gtctggaacg ccgttatcat ttccatgtac cgcgaacacc ttctctcgat 4020 cgagcacgtc caaaaacttc tttaccatca aatccaatct gatcaacccg gcaagcgtac 4080 tcttcgagcg cccgctttct ttatctctca gagcgagaaa ggttccaagg ccgagttttt 4140 ccccaagggc agtgaagccg agcgacgaat ctgtttcttt gctcagtccc tcaccacctc 4200 catccctgct cctattcctg ttgatgctat gcctactttc actgtgcttg ttcctcacta 4260 ttctgagaag atcttgctct ctcttaggga gattatcagg gaagaggacc agaacacccg 4320 tgtcacttta ctggagtact tgaagcagct ccaccctgtc gaatgggaca actttgtacg 4380 cgacacgaag atcctcgctg aagagtccga cgctttcaat ggtggcaatc ccttcgcgtc 4440 tgatgagaag gaggaagcca agaaggccga tgacattccg ttctacacca tcggtttcaa 4500 gtctgccgct cccgaataca ctcttcgtac tcgaatttgg gcttctcttc gtgctcagac 4560 cttgtaccga actgtatctg gtttcatgaa ctacagcaag gccatcaagc ttctttaccg 4620 agttgaaaac cccgaggttg tccagctttt tggtggcaac actgaccagc tcgaaaggga 4680 gcttgaaagg atggctcgac gaaaattcaa gtttgtcgtt tctatgcagc gatactcgaa 4740 gttcaacaag gaagagcacg aaaacgcgga atttttgtta cgtgcctacc ccgacttgca 4800 gattgcctac ctcgacgagg agcctcctcg caaggacggc ggcgagtctc gtatcttctc 4860 tgccttgatt gacggtcact ctgaaataat gcctaacggt cgacgacgcc ccaagttccg 4920 tattgagctt cctggtaacc ccattcttgg tgacggtaaa tctgataacc agaaccacgc 4980 cattgttttc taccgaggcg agtacctcca gctcatcgat gcgaaccagg acaactatct 5040 cgaagagtgt ttgaagattc gaaacgtcct cggcgagttt gaggaattca aggtatctac 5100 ccaaagccct tacgctgccc agggtcacgc cgactttgcc aagttccccg ttgccatttt 5160 gggtgcccga gaatacattt tctccgaaaa cattggtatc cttggtgaca ttgctgctgg 5220 taaagaacag actttcggta ctcttgctgc tagatcttta tcctacatcg gtggtaagct 5280 gcactacggt caccccgatt tcctcaacgc tatctacatg aacactcgtg gtggtgtttc 5340 caaggctcag aagggtttgc atcttaacga agatatcttc gctggtatgc ttgctttcgg 5400 tcgaggtggt cgtatcaagc attccgaata ctaccagtgt ggtaagggtc gagatcttgg 5460 ttttggtact attctcaatt tccagactaa aattggtact ggtatgggcg aacaaatgct 5520 ttcacgagag tattactact tgggcaccca gcttccgatc gatagattcc tgactttcta 5580 ttatggtcac cccggtttcc acatcaacaa cattttggtc atgatgtctg tccaagtctt 5640 catgcttgct ctcgtattcc tcggtactct taacaagcaa cttaccgtct gcagatactc 5700 ttctggtggt gacatccttc ctggtcagag tggttgttac aaccttgtcc ctgtgttcaa 5760 atggatcaag aggtgtatca tctccatctt catcgtgttc tggatggcct ttgttcctct 5820 tttcgtacag gaacttaccg aacggggtac tggccgagct attctccgac tgtgcaagca 5880 cttcttgtcg ctttcgccag tcttcgaagt gttctccacc cagatttaca tgcactccat 5940 cctcaacgac ttgactttcg gtggtgccag gtatatcgcc actggtcgtg gtttcgctac 6000 cactcgaatt tctttcagca ttctctagta agtgctgttc ttttctgtgc gggccgtcta 6060 ctaacggtga gcagctcccg attcgctgga ccttcgatct acctcggtat gcgtaccctt 6120 gtcctccttc tctttatcac cctcacagtc tgggttcctc atcttatcta cttctggatt 6180 actgtcgtcg gtctttgtgt tgctcctttc cttttcaacc ctcaccagtt cgccattgcc 6240 gactttatca tcgactaccg agaattcctt cgttggatgt ctcgaggtaa ttcgcgaaca 6300 catgccaact cttgggtcgg ttactgtcgg ttgtcccgaa ctagggtcac tggtttcaag 6360 cgcaagaggt tgggtctccc tagtgagaag ttgtcgagtg atgtgcctag ggctccctgg 6420 aaggctattc tgatcggaga aatcatcggc cccatctgtt tggctattct cttcgtgatc 6480 tgttatctct tcatcaagag tttcgccgtg gacggtcaaa ttcagcctgg tttggtcagg 6540 attgcgatca tcgcccttgg tcctattgtt tggaacatgg ctcttttgat tactctgttt 6600 ttgatttctg tcttccttgg cccttgtgta agtctttctt ttatcattta tcatgaacta 6660 tagctaatga ccacctcaca gctgaactcc tacactcacc agtttggagc tacaatggct 6720 gccctcgctc acttcggtgc tgtcgctggt atgcttgtct tcttcgagct cctttggttc 6780 cttgagcttt ggaacacttc ccatgccgtc ctcggtatca tcgctgtcat cagtgtgcag 6840 aggtgtatct tcaagttcct catcgctgtt ttcttgtcgc gagagttcaa gcacgacgaa 6900 accaacaggg cctggtggac tgtacgtttg tatctaattg cccaggcttg agcatatatt 6960 gacatttatt tccagggtgt ttggttcaac cgtggtttgg gttctcacgc gctctctcag 7020 cccgcccgag agtttgttgt caagacaatc gaaatgggct tgtactctgc cgactttatt 7080 gcctgccact gtaggtgtat tggtcttcat ctttcgtagt ccccactgac cccacaactt 7140 tagtgctcct cgccctcctt accatcccca tgtttatccc ttactttgac cgagttcacg 7200 ctactatgct cttctggctc gcgcccaatc agcaaatcag gcctcctatt tacagcttca 7260 ggcagaggag ccaacgacga aagattgttt tcaagtgtaa gccacttccg tcagccaaat 7320 gaatgtctgg tcgctaatgt acagcaaata gacggtcttt tgtacttgat tatccaaggt 7380 atatttattg ccctcatcgt cgttcccatc attttcaagg acgtcgccgg ccttacgcca 7440 aagagtgtgc ctttcaacgg tatcatctaa gtaccgagcg ttatctctca acagtccttt 7500 gacaatccat tttcctcaac agtccttttc cccgcgcatt tcaacgacac aatcccctgt 7560 ctcgcattga acgatttaca acgtacgcca cttcaacaaa ctcaggatgt cactgagcat 7620 atcgagtttg acggatctcg aaacaatgga caatttttta cacattcgct ttgagtcaaa 7680 actgttcttt tattttgttt ttttttccta tttttctcta gtttttccat ctcttgatgt 7740 gcaagttgaa tgttcagatt gagcgtacat ggattatacc cctcagtatc ttagatatgg 7800 atgaatgact ataacgacag caagccagga cctaatgtta agtttgactt tctggtgcag 7860 attcctcaaa ggtagtacgg tattatgcaa aatgatgcga tgcaccataa gtggttcgtc 7920 gaattacatg tcacggaaag atacatctcg ttgtaattct aggcgacata gatacatgat 7980 aaaacgtagc aaggtcgtcg tcattgtagt cgttaaaatc gat 8023 // |
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