EBI Dbfetch

ID   AF086786; SV 1; linear; mRNA; STD; MAM; 1928 BP.
XX
AC   AF086786;
XX
DT   30-JUN-1999 (Rel. 60, Created)
DT   15-APR-2005 (Rel. 83, Last updated, Version 4)
XX
DE   Delphinapterus leucas erythroid-specific 5-aminolevulinic acid synthase
DE   (ALS2) mRNA, complete cds.
XX
KW   .
XX
OS   Delphinapterus leucas (beluga whale)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
XX
RN   [1]
RP   1-1928
RX   DOI; 10.1016/S0305-0491(99)00052-8
RX   PUBMED; 10425720.
RA   Kreiling J.A., Duncan R., Faggart M.A., Cornell N.W.;
RT   "Comparison of the beluga whale (Delphinapterus leucas) expressed genes for
RT   5-aminolevulinate synthase with those in other vertebrates";
RL   Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 123(2):163-174(1999).
XX
RN   [2]
RP   1-1928
RA   Kreiling J.A., Faggart M.A., Cornell N.W.;
RT   ;
RL   Submitted (25-AUG-1998) to the EMBL/GenBank/DDBJ databases.
RL   Bay Paul Center for Comparative Molecular Biology and Evolution, Marine
RL   Biological Laboratory, 7 MBL St., Woods Hole, MA 02543, USA
XX
DR   RFAM; RF00037; IRE.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..1928
FT                   /organism="Delphinapterus leucas"
FT                   /mol_type="mRNA"
FT                   /cell_type="erythrocytes"
FT                   /db_xref="taxon:9749"
FT   misc_feature    1..28
FT                   /gene="ALS2"
FT                   /note="iron-responsive element"
FT   CDS             59..1807
FT                   /codon_start=1
FT                   /gene="ALS2"
FT                   /product="erythroid-specific 5-aminolevulinic acid
FT                   synthase"
FT                   /function="first reaction in heme biosynthesis"
FT                   /EC_number="2.3.1.37"
FT                   /db_xref="GOA:Q9XT75"
FT                   /db_xref="HSSP:1H7D"
FT                   /db_xref="InterPro:IPR015421"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q9XT75"
FT                   /protein_id="AAD41464.1"
FT                   /translation="MLLQRCPVLIRSPTAILGKMIKTHQFLIGIGRCPILATQGTTCSQ
FT                   IHLKATKAGGDSPSWAKSHCPFMLLELQDGKSKIVQKAAPEVQEDVKTFKTDLPISLAS
FT                   TSLRKPFFSPQEPEKNSEKVTHLIQNNMAGNHVFGYDQFFRNKIMEKKQDHTYRVFKTV
FT                   NRWADAYPFAEHFFEASVASKDVSVWCSNDYLGMSRHPRVLQATQETLQRHGAGAGGTR
FT                   NISGTSRFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHA
FT                   SMIQGIRNSGAAKFVFRHNDPDHLKKLLKKSNPETPKIVAFETVHSMDGAICPLEELCD
FT                   VAHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTR
FT                   DLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMD
FT                   RGLPVIPCPSHIIPIRVGDAALNSRICDLLLSKHGIYVQAINYPTVPRGEELLRLAPSP
FT                   HHSPQMMEDFVEKLLAAWTEVGLPLQDVSIAACNFCRRPVHFELMSEWERSYFGNMGPQ
FT                   YVTTYA"
FT   misc_feature    71..85
FT                   /gene="ALS2"
FT                   /note="pentapeptide=RCPVL; Region: heme regulatory motif"
FT   misc_feature    152..166
FT                   /gene="ALS2"
FT                   /note="pentapeptide=RCPIL; Region: heme regulatory motif"
FT   misc_feature    248..262
FT                   /gene="ALS2"
FT                   /note="pentapeptide=HCPFM; Region: heme regulatory motif"
XX
SQ   Sequence 1928 BP; 430 A; 540 C; 514 G; 444 T; 0 other;
     ttcgttcgtc ctcagtgcag ggcaacagaa cttcgggctc aagagggtgg cagcagccat        60
     gttgctacag cgttgcccag tgcttatccg gagccccaca gccatcctgg gcaagatgat       120
     taagactcac cagttcctga ttggtattgg acgctgtccc atcctggcca cccaaggaac       180
     aacctgttct caaatccacc ttaaggcaac caaggctgga ggggactctc catcttgggc       240
     caagagccac tgtcccttca tgctgttgga actccaggat gggaagagta aaattgtgca       300
     gaaggcagcc ccagaagtcc aggaggatgt gaagactttc aagacagacc tgcccatctc       360
     cctggcctca accagcctga ggaagccatt cttcagtccc caggagccag agaagaattc       420
     agagaaggtc acacacctga ttcagaacaa catggctgga aaccatgtct ttggttatga       480
     ccagtttttt aggaacaaga tcatggagaa gaaacaggac cacacctacc gtgttttcaa       540
     aactgtgaac cgctgggctg atgcataccc ctttgccgaa cacttctttg aggcatctgt       600
     ggcttcaaag gatgtgtctg tctggtgcag taatgactac ctgggcatga gccggcaccc       660
     tcgggtcttg caagccacac aagagaccct gcagcgtcac ggagctggag ctggtggcac       720
     ccgcaacatc tcgggtacca gcaggtttca tgttgagctg gagcaagagc tggctgagct       780
     gcaccagaag gactcagccc tgctattctc ttcctgcttt gtggccaatg actctactct       840
     cttcaccttg gccaagatct tgccagggtg cgagatttac tcagatgcag gcaaccatgc       900
     ttcaatgatc caaggtatcc gcaatagtgg agcagcgaag tttgtcttca ggcacaatga       960
     ccctgaccac ctgaagaaac ttctaaagaa gtctaaccct gagacaccca aaattgtggc      1020
     ctttgagact gttcactcca tggatggtgc catctgtccc cttgaggagt tgtgtgatgt      1080
     ggcccaccag tatggggctc tgaccttcgt ggatgaggtt catgctgtag gactgtatgg      1140
     gtcccggggt gctgggattg gggagcgtga tggaattatg cacaagattg acatcatctc      1200
     tggaactctt ggcaaggcct ttggctgtgt gggcggctat atcgccagca cccgtgactt      1260
     ggtggacatg gtgcgctcct atgctgctgg cttcatcttc accacttcac tgcctcccat      1320
     ggtgctctct ggggctctgg aatccgtgcg actgctcaag ggagaggagg gccaagccct      1380
     gaggcgggcc caccagcgca atgtcaagca catgcgtcag ctactaatgg acagaggcct      1440
     tcctgtcatc ccatgcccca gccacatcat ccccattcgg gtgggtgatg cagcactgaa      1500
     cagcaggatc tgtgatctcc tgctctccaa gcatggcatc tatgtgcaag ccatcaacta      1560
     cccaactgtc ccccggggtg aggagctgct gcgcttggca ccctcccccc accacagccc      1620
     tcagatgatg gaagactttg tggagaagct gctggcagcc tggactgagg tggggctgcc      1680
     cctccaggat gtatctatag ctgcctgcaa cttctgtcgt cgtcctgtgc acttcgagct      1740
     catgagtgag tgggaacgtt cctactttgg gaacatgggg ccccagtatg tcaccaccta      1800
     tgcctgagaa acaagctgcc ttggatcccc accacacctg cacctctctt ggggctgggc      1860
     cgcctcctgt cctctgcttt gttgtgtgcc tctagctgac ttgagcctga aaataaagag      1920
     caaagtgt                                                               1928
//