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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   CAK46627; SV 1; linear; genomic DNA; STD; FUN; 1179 BP.
XX
PA   AM270320.1
XX
DE   Aspergillus niger hypothetical protein
XX
OS   Aspergillus niger
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae;
OC   Aspergillus.
OX   NCBI_TaxID=5061;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..1179
FT                   /organism="Aspergillus niger"
FT                   /mol_type="genomic DNA"
FT                   /clone="An14c0130"
FT   CDS             join(AM270320.1:257881..257922,AM270320.1:257976..258758,
FT                   AM270320.1:258810..259098,AM270320.1:259149..259213)
FT                   /locus_tag="An14g03910"
FT                   /EC_number="2.4.1.131"
FT                   /note="Function: kre2 of C. albicans is involved in the
FT                   synthesis of mannoproteins, the third major class of
FT                   macromolecule found in the cell wall."
FT                   /note="Function: kre2 of C. albicans transfers an
FT                   alpha-D-mannosyl residue from GDP-mannose into lipid-linked
FT                   oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose
FT                   linkage."
FT                   /note="Golgi"
FT                   /note="Phenotype: both heterozygous and homozygous kre2
FT                   null mutants of C. albicans showed strong attenuation of
FT                   virulence in guinea pig and mouse models of systemic
FT                   candidosis, which, in guinea pigs, could be attributed to a
FT                   decreased ability to reach and/or adhere internal organs."
FT                   /note="Phenotype: the absence of kre2 in C. albicans
FT                   reduced the ability of C. albicans cells to adhere to each
FT                   other, to human buccal epithelial cells, and to rat vaginal
FT                   epithelial cells."
FT                   /note="Remark: kre2 of C. albicans is also called mnt1."
FT                   /note="Title: strong similarity to
FT                   alpha-1,2-mannosyltransferase kre2 - Candida albicans"
FT                   /db_xref="GOA:A2R3D5"
FT                   /db_xref="InterPro:IPR002685"
FT                   /db_xref="UniProtKB/TrEMBL:A2R3D5"
FT                   /inference="profile:COGS:COG5020"
FT                   /inference="profile:PFAM:PF01793"
FT                   /inference="similar to AA sequence:SWISSPROT:KRE2.CANAL"
FT                   /protein_id="CAK46627.1"
FT                   /translation="MAIGPLRYLLFAITGLAIFFFISRSAIPIPENIGTKLTPATYKDT
FT                   FSSSHSSQNDALSSSGPIKDIPTDRVNATFVTLARNTDLWEMVKSIRTVEDRFNHNYHY
FT                   DWVFLNDKPFDEEFKKVTSALISGNTHYGVIPKEHWSYPEWIDQDKAKKVRQEMGEKKI
FT                   IYGDSESYRHMCRYESGFFFRHPLMLNYEYYWRVEPSIELFCDVSFDPFRYVKENDKKY
FT                   SFVLSLYEYYDTIPSLWGTVQKFMEEHPEHIADGNSMGFLSDDGGKTYNKCHFWSNFEI
FT                   GSLEWLRSKEYIDYFETLDHAGGFFYERWGDAPVHSIAAGLLLKKEQIHFFNEIGYYHV
FT                   PFTHCPTGEQLRLDLKCHCNPKDNFDWKGYSCTSRFFQVNDMDKPKGYENES"
XX
SQ   Sequence 1179 BP; 294 A; 314 C; 301 G; 270 T; 0 other; 2573466154 CRC32;
     atggctatag ggccattgcg atatcttttg tttgccatca cggggttggc catcttcttc        60
     tttatctcta ggagcgctat cccaatcccc gagaatatcg gcacaaaatt aacccccgcg       120
     acctacaaag acaccttttc ctcctctcac tcctcgcaaa atgatgcgct gtcatcaagt       180
     ggaccgatca aagacatccc gacggaccgc gtgaacgcca cctttgtgac cctggcgcgc       240
     aacactgatc tttgggagat ggtcaagtcc atccggacgg tggaggaccg ctttaaccac       300
     aactatcact acgactgggt atttttgaac gacaagccgt ttgacgagga gttcaagaag       360
     gtcacgtcag ccttgatctc cggcaataca cactatggcg tgatcccgaa ggagcattgg       420
     tcttatcccg agtggatcga ccaggataag gccaagaagg tccgacagga aatgggagag       480
     aagaagatca tctacggcga ctcggaaagc taccgtcaca tgtgccgtta tgagtccggg       540
     ttcttcttcc ggcacccgtt gatgctgaac tatgagtact actggcgtgt ggagcccagc       600
     attgagctct tctgtgatgt cagctttgac ccgttccgct acgtgaaaga gaacgacaag       660
     aagtacagct tcgtgctgag cctatacgag tactacgaca ccatcccgag cctgtggggt       720
     acggtgcaaa agttcatgga agaacacccg gagcatatcg cggacggtaa ctccatggga       780
     ttcttgagtg atgatggcgg caagacctac aacaagtgtc acttctggtc caactttgag       840
     attggaagtc tggaatggct gcggtccaag gaatacattg actacttcga gacgctcgac       900
     cacgctggtg gcttcttcta tgaacgttgg ggcgatgcac cagtccactc tatcgctgcg       960
     ggacttctct tgaagaagga gcagatccat ttcttcaacg agattggcta ctaccacgtc      1020
     ccctttaccc actgcccgac tggtgagcag cttaggctgg acctgaagtg ccactgcaac      1080
     cctaaagaca actttgactg gaagggatac tcttgcacgt cccggttctt ccaagtcaac      1140
     gacatggaca agcccaaggg ctacgagaat gagagctga                             1179
//
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