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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   CAE55614; SV 1; linear; genomic DNA; STD; PRO; 852 BP.
XX
PA   BX842583.1
XX
DE   Mycobacterium tuberculosis H37Rv ARYLAMINE N-ACETYLTRANSFERASE NAT
DE   (ARYLAMINE ACETYLASE)
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..852
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT   CDS             complement(BX842583.1:190155..191006)
FT                   /transl_table=11
FT                   /gene="nat"
FT                   /locus_tag="Rv3566c"
FT                   /standard_name="nhoA"
FT                   /product="ARYLAMINE N-ACETYLTRANSFERASE NAT (ARYLAMINE
FT                   ACETYLASE)"
FT                   /function="COULD HAVE A ROLE IN ACETYLATING, AND HENCE
FT                   INACTIVATING, THE ANTITUBERCULAR DRUG ISONIAZID [CATALYTIC
FT                   ACTIVITY: ACETYL-CoA + ARYLAMINE = CoA +
FT                   N-ACETYLARYLAMINE]."
FT                   /EC_number="2.3.1.5"
FT                   /note="Rv3566c, (MT3671, MTCY06G11.13c), len: 283 aa. nat
FT                   (alternate gene name: nhoA), arylamine N-acetyltransferase
FT                   (EC 2.3.1.5) (see citations below), highly similar to
FT                   O86309|NAT_MYCSM ARYLAMINE N-ACETYLTRANSFERASE from
FT                   Mycobacterium smegmatis (see citation below) (275 aa),
FT                   FASTA scores: opt: 1114, E(): 3e-66, (60.95% identity in
FT                   274 aa overlap). Also highly similar to others e.g.
FT                   Q98D42|BAB51429|MLR4870 from Rhizobium loti (Mesorhizobium
FT                   loti) (278 aa), FASTA scores: opt: 697, E(): 1.1e-38,
FT                   (44.1% identity in 272 aa overlap); P77567|NHOA_ECOLI|B1463
FT                   from Escherichia coli strain K12 (281 aa), FASTA scores:
FT                   opt: 537, E(): 4.4e-28, (38.85% identity in 273 aa
FT                   overlap); Q00267|NHOA_SALTY from Salmonella typhimurium
FT                   (281 aa), FASTA scores: opt: 507, E(): 4.3e-26, (34.8%
FT                   identity in 273 aa overlap); etc. BELONGS TO THE ARYLAMINE
FT                   N-ACETYLTRANSFERASE FAMILY. Note that previously known as
FT                   nhoA (332 aa) and that nucleotide 4007874 has been changed
FT                   since first submission (G deleted)."
FT                   /db_xref="GOA:P0A5L8"
FT                   /db_xref="HSSP:1GX3"
FT                   /db_xref="InterPro:IPR001447"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A5L8"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /func_characterised="identical sequence"
FT                   /protein_id="CAE55614.1"
FT                   /translation="MALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPLL
FT                   GVPVDDLSPQALADKLVLRRRGGYCFEHNGLMGYVLAELGYRVRRFAARVVWKLAPDAP
FT                   LPPQTHTLLGVTFPGSGGCYLVDVGFGGQTPTSPLRLETGAVQPTTHEPYRLEDRVDGF
FT                   VLQAMVRDTWQTLYEFTTQTRPQIDLKVASWYASTHPASKFVTGLTAAVITDDARWNLS
FT                   GRDLAVHRAGGTEKIRLADAAAVVDTLSERFGINVADIGERGALETRIDELLARQPGAD
FT                   AP"
XX
SQ   Sequence 852 BP; 153 A; 287 C; 266 G; 146 T; 0 other; 432949914 CRC32;
     atggcactgg atctgaccgc gtacttcgat cgcatcaact atcgcggcgc taccgatcca        60
     accctggatg ttctgcagga tctggtgacc gtgcacagtc gaacgattcc gttcgagaac       120
     ctcgacccgc tgctgggggt gccggtcgac gacctcagtc cacaggcgct ggccgacaag       180
     ctggtacttc ggcgccgagg cgggtactgc tttgagcaca acgggctgat gggttatgtg       240
     ctggccgaac tcggctatcg ggtgcgccga ttcgccgccc gcgtcgtctg gaagctcgcg       300
     ccggacgcgc ccctgccgcc gcagacgcac accctgctgg gggtcacgtt ccccggctcg       360
     ggcggatgct atctcgtcga cgtcggattc ggcggccaaa caccgacctc accgcttcgc       420
     ctcgaaaccg gcgccgtcca gccgacaacg cacgaacctt atcggctcga ggaccgcgtc       480
     gacggctttg tcttgcaggc gatggtccgg gacacatggc agacactgta cgaattcacc       540
     acccagaccc gcccgcagat cgatctgaaa gtggccagct ggtacgcctc aacacacccg       600
     gcatcgaagt tcgtcacggg actgaccgcc gcggtgatca ccgacgacgc ccggtggaac       660
     ctatctggcc gcgaccttgc cgttcaccgt gccggtggta ccgagaagat ccgccttgcc       720
     gatgcggcag cggttgtcga caccctgagc gaacggttcg ggatcaacgt ggcagatatc       780
     ggcgagcgcg gcgcgctcga gacgcgcatc gacgagctat tggctcggca gccaggagcc       840
     gatgcgccgt aa                                                           852
//
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