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EBI DbfetchID CAD95856; SV 1; linear; genomic DNA; STD; PRO; 2805 BP. XX PA BX248346.1 XX DE Mycobacterium bovis AF2122/97 DNA TOPOISOMERASE I TOPA (OMEGA-PROTEIN) DE (RELAXING ENZYME) (UNTWISTING ENZYME) (SWIVELASE) (TYPE I DNA DE TOPOISOMERASE) (NICKING-CLOSING ENZYME) XX OS Mycobacterium bovis AF2122/97 OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. OX NCBI_TaxID=233413; XX FH Key Location/Qualifiers FH FT source 1..2805 FT /organism="Mycobacterium bovis AF2122/97" FT /strain="AF2122/97" FT /mol_type="genomic DNA" FT CDS complement(BX248346.1:270690..273494) FT /transl_table=11 FT /gene="topA" FT /locus_tag="Mb3670c" FT /product="DNA TOPOISOMERASE I TOPA (OMEGA-PROTEIN) FT (RELAXING ENZYME) (UNTWISTING ENZYME) (SWIVELASE) (TYPE I FT DNA TOPOISOMERASE) (NICKING-CLOSING ENZYME)" FT /EC_number="5.99.1.2" FT /note="Mb3670c, topA, len: 934 aa. Equivalent to Rv3646c, FT len: 934 aa, from Mycobacterium tuberculosis strain H37Rv, FT (100.0% identity in 934 aa overlap). topA, DNA FT topoisomerase I (EC 5.99.1.2) (see citation below), FT equivalent to O69548|TOP1_MYCLE|TOPA|ML0200|MLCB2548.31c FT DNA TOPOISOMERASE I from Mycobacterium leprae (947 aa) FT FASTA scores: opt: 5150, E(): 0, (84.6% identity in 936 aa FT overlap). Also highly similar to many e.g. FT Q9X909|TOP1_STRCO|TOPA|SCH5.06c from Streptomyces FT coelicolor (952 aa), FASTA scores: opt: 2754, E(): FT 1.3e-153, (61.3% identity in 928 aa overlap); FT P73810|TOP1_SYNY3|TOPA|SLR2058 from Synechocystis sp. FT strain PCC 6803 (898 aa), FASTA scores: opt: 1442, E(): FT 9.1e-77, (47.15% identity in 927 aa overlap); FT P47368|TOP1_MYCGE|TOPA|MG122 from Mycoplasma genitalium FT (709 aa), FASTA scores: opt: 865, E(): 4.8e-43, (30.3% FT identity in 736 aa overlap); FT P06612|TOP1_ECOLI|TOPA|SUPX|B1274 from Escherichia coli FT strain K12 (865 aa), FASTA scores: opt: 397, E(): 0, (39.6% FT identity in 704 aa overlap); etc. BELONGS TO PROKARYOTIC FT TYPE I/III TOPOISOMERASE FAMILY." FT /db_xref="GOA:P0A621" FT /db_xref="HSSP:1ECL" FT /db_xref="InterPro:IPR006171" FT /db_xref="UniProtKB/Swiss-Prot:P0A621" FT /func_characterised="identical sequence" FT /protein_id="CAD95856.1" FT /translation="MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESS FT RGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVD FT ELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDA FT QETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDIL FT AKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALA FT AGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYI FT TYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETF FT ATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSAT FT GRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARY FT TEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGR FT LVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEG FT IDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELT FT LQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKR FT QKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLK FT RGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKD FT GRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKA FT AKRD" XX SQ Sequence 2805 BP; 543 A; 929 C; 918 G; 415 T; 0 other; 3241514867 CRC32; ttggctgacc cgaaaacgaa gggccgtggc agcggcggca atggcagcgg ccggcgactg 60 gtcatcgtcg agtcgcccac caaggcgcgc aagctggcct cctacctggg ctctggctac 120 atcgtcgagt cctcccgggg gcacatccgt gacttgccgc gggccgcgtc ggatgtaccc 180 gcaaagtaca agtcgcagcc gtgggcgcgg ctcggggtca acgtcgacgc cgacttcgaa 240 ccgctctaca tcatcagccc ggagaaacgg agcaccgtca gcgagctcag gggcctgctc 300 aaagacgtgg acgagctgta tctggccacg gatggggacc gtgagggcga agctattgcc 360 tggcatctgc tggaaaccct caaaccgcgc ataccggtaa agcggatggt cttccacgag 420 atcaccgaac cggcgatccg cgccgccgcc gagcaccccc gcgacctaga catcgacctg 480 gtcgacgcgc aggagacccg gcgcatcctg gaccggctgt acggctacga agtcagccca 540 gtgctgtgga agaaggtcgc ccccaagttg tcggcgggcc gggtgcagtc ggtggccacc 600 cgcatcatcg tggcgcgcga acgcgaccgc atggcgttcc gcagcgcggc ctactgggac 660 atccttgcca agctggatgc cagcgtgtcc gacccggacg ccgcgccgcc caccttcagc 720 gcccggctga cggccgtggc tggccggcgg gtggccactg gccgcgattt cgactcgctg 780 ggcacgctgc gcaaaggcga cgaagtcatt gtgctcgacg aggggagcgc gaccgcgttg 840 gccgcgggcc tggatggcac gcagctgacc gtggcctcgg ccgaggagaa gccctacgcc 900 cggcgcccgt acccgccgtt catgacctcc acgctgcagc aagaggccag ccgcaagctg 960 cggttctccg ccgagcggac gatgagcatc gcccagcggc tgtacgaaaa cggctacatc 1020 acctatatgc gtaccgactc caccacgctg tcggagtcgg cgatcaacgc cgcacgtacc 1080 caggcgcgcc agctctacgg cgacgagtac gtcgcgccgg cgccgcgcca atacacccgc 1140 aaggtgaaga acgcccagga agcgcacgag gctatccggc ccgccggtga aacgtttgcc 1200 accccggacg cggtgcgtcg cgaactcgac ggtcccaaca ttgatgattt ccggctctat 1260 gagctgattt ggcaacgcac cgtagcctcg cagatggccg atgcgcgggg catgacgctg 1320 agcctgcgga tcactggcat gtcggggcac caggaggtgg tgttctccgc gaccggacgc 1380 accttgacgt tcccgggctt cctcaaggcc tacgtggaga ccgtggacga gctggtcggc 1440 ggcgaggctg acgatgccga gcggcgactg ccccatctga ccccgggtca acggttggac 1500 atcgtcgagt tgaccccaga cggccatgcc accaacccgc cggcccgcta caccgaggcg 1560 tcgctggtca aagcgctcga ggagctgggc atcggccgcc cgtcgaccta ctcgtcgatc 1620 atcaagacca tccaggatcg cggctacgtg cacaagaagg gcagtgcact ggtgccgtca 1680 tgggtggcgt tcgcggtaac cggtctgctc gagcagcatt tcggtcggct cgtcgactac 1740 gacttcaccg cggcgatgga agacgagctc gacgagatcg ccgccggcaa cgagcgccgc 1800 accaactggc tcaacaactt ctactttggt ggcgatcacg gtgtgcccga ttcggtagcc 1860 cgatcgggtg gcctcaagaa gcttgtcggg atcaatctcg agggcatcga cgcacgagaa 1920 gtaaactcta tcaagctttt tgacgacacc cacggacgcc ccatatatgt tcgggtgggc 1980 aagaacggtc cctacctgga acgtttggtg gccggcgaca ccggtgagcc cacgccgcag 2040 cgggccaacc tcagcgactc gattaccccg gacgagctga ctctacaggt ggccgaagag 2100 ctctttgcca caccgcaaca gggacggact ttgggcttgg acccagaaac cggccacgag 2160 atcgtggcca gggaaggccg gtttgggccg tatgtgaccg agatcctgcc ggagcctgcg 2220 gctgatgcgg ccgcggccgc tcagggagtc aagaaacgcc agaaggccgc cgggcccaaa 2280 ccgcgcaccg gttcgttgct gcggagcatg gacctacaga cggtcaccct cgaagacgcg 2340 ctgaggctgc tgtcactgcc gcgcgtggtc ggagtggacc ccgcctcggg tgaggagatc 2400 accgcgcaga acgggcgcta cggaccgtat ctaaagcgcg gcaacgattc tcgatcactg 2460 gtcaccgaag accagatatt caccatcacg ctcgacgaag ccctgaagat ctacgcagag 2520 ccgaaacgtc gtggccggca aagcgcttcg gctccgccgc tgcgcgagct gggaacagat 2580 ccggcgtcgg gcaagccaat ggtcatcaag gacggccgat tcgggccgta cgtcaccgac 2640 ggtgagacca atgccagcct gcgtaagggc gacgacgtgg cttccataac cgacgagcgc 2700 gccgccgagc tgttggccga tcgccgagcc cggggtccgg caaaacggcc agccaggaaa 2760 gctgcccgga aggtgccggc gaagaaggca gccaagcgcg actag 2805 // |
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