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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   CAD93649; SV 1; linear; genomic DNA; STD; PRO; 1356 BP.
XX
PA   BX248336.1
XX
DE   Mycobacterium bovis AF2122/97 CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1)
DE   (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM)
XX
OS   Mycobacterium bovis AF2122/97
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..1356
FT                   /organism="Mycobacterium bovis AF2122/97"
FT                   /strain="AF2122/97"
FT                   /mol_type="genomic DNA"
FT   CDS             complement(BX248336.1:191871..193226)
FT                   /transl_table=11
FT                   /gene="cyp51"
FT                   /locus_tag="Mb0787c"
FT                   /product="CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1)
FT                   (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA
FT                   DEMETHYLASE) (P450-14DM)"
FT                   /EC_number="1.14.14.-"
FT                   /note="Mb0787c, cyp51, len: 451 aa. Equivalent to Rv0764c,
FT                   len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,
FT                   (100.0% identity in 451 aa overlap). cyp51, cytochrome P450
FT                   51 (sterol 14-alpha demethylase) (EC 1.14.14.-), similar to
FT                   others e.g. Q16850|CP51_HUMAN CYTOCHROME P450 51 (CYPL1)
FT                   (P450L1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA
FT                   DEMETHYLASE) from Homo sapiens (509 aa), FASTA scores: opt:
FT                   848, E(): 0, (33.9% identity in 439 aa overlap);
FT                   NP_172633.1|NC_003070 putative obtusifoliol 14-alpha
FT                   demethylase from Arabidopsis thaliana (488 aa);
FT                   P93596|CP51_WHEAT CYTOCHROME P450 51 (CYPL1) (P450-L1A1)
FT                   (OBTUSIFOLIOL 14-ALPHA DEMETHYLASE) from Triticum aestivum
FT                   (453 aa); etc. Also similar to many other Mycobacterium
FT                   tuberculosis cytochromes P450 e.g. Rv1394c, FASTA score:
FT                   (22.5% identity in 444 aa overlap). Contains PS00086
FT                   Cytochrome P450 cysteine heme-iron ligand signature.
FT                   BELONGS TO THE CYTOCHROME P450 FAMILY."
FT                   /db_xref="GOA:P0A513"
FT                   /db_xref="InterPro:IPR002403"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0A513"
FT                   /func_characterised="identical sequence"
FT                   /protein_id="CAD93649.1"
FT                   /translation="MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQL
FT                   AGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAA
FT                   LRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDG
FT                   RFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSD
FT                   RDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAA
FT                   VIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIH
FT                   EGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAF
FT                   AIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV"
XX
SQ   Sequence 1356 BP; 260 A; 436 C; 423 G; 237 T; 0 other; 76478681 CRC32;
     atgagcgctg ttgcactacc ccgggtttcg ggtggccacg acgaacacgg ccacctcgag        60
     gagttccgca ccgatccgat cgggctgatg caacgggtcc gcgacgaatg cggagacgtc       120
     ggtaccttcc agctggccgg gaagcaggtc gtgctgctgt ccggctcgca cgccaacgaa       180
     ttcttcttcc gggcgggcga cgacgacctg gaccaggcca aggcataccc gttcatgacg       240
     ccgatcttcg gcgagggcgt ggtgttcgac gccagcccgg aacggcgtaa agagatgctg       300
     cacaatgccg cgctacgcgg cgagcagatg aagggccacg ccgccaccat cgaagatcaa       360
     gtccgacgga tgatcgccga ctggggtgag gccggcgaga tcgatctgct ggacttcttc       420
     gccgagctga ccatctacac ctcctcggcc tgcctgatcg gcaagaagtt ccgcgaccag       480
     ctcgacgggc gattcgccaa gctctatcac gagttggagc gcggcaccga cccactagcc       540
     tacgtcgacc cgtatctgcc gatcgagagc ttccgtcgcc gcgacgaagc ccgcaatggt       600
     ctggtggcac tggttgcgga catcatgaac ggccggatcg ccaacccacc caccgacaag       660
     agcgaccgtg acatgctcga cgtgctcatc gccgtcaagg ctgagaccgg cactccccgg       720
     ttctcggccg acgagatcac cggcatgttc atctcgatga tgttcgccgg ccatcacacc       780
     agctcgggta cggcttcgtg gacgctgatc gagttgatgc gccatcgcga cgcctacgcg       840
     gccgtgatcg acgaactcga cgagctgtac ggcgacggcc gatcggtgag tttccatgcg       900
     ctgcgccaga ttccgcagct ggaaaacgtg ctgaaagaga cgctgcgcct gcaccctccg       960
     ctgatcatcc tcatgcgagt ggccaagggc gagttcgagg tgcaaggcca ccggattcat      1020
     gagggcgatc tggtggcggc ctccccggcg atctccaacc ggatccccga agacttcccc      1080
     gatccccacg acttcgtgcc agcacgatac gagcagccgc gccaggaaga tctgctcaac      1140
     cgctggacgt ggattccgtt cggcgccggc cggcatcgtt gcgtgggggc ggcgttcgcc      1200
     atcatgcaga tcaaagcgat cttctcggtg ttgttgcgcg agtatgagtt tgagatggcg      1260
     caaccgccag aaagctatcg taacgaccat tcgaagatgg tggtgcagtt ggcccagccc      1320
     gcttgcgtgc gctaccgccg gcgaacggga gtttaa                                1356
//
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