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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   CAB10749; SV 1; linear; genomic DNA; STD; PRO; 990 BP.
XX
PA   BX842573.1
XX
DE   Mycobacterium tuberculosis H37Rv PROBABLE DELTA-AMINOLEVULINIC ACID
DE   DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH)
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..990
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT   CDS             BX842573.1:262695..263684
FT                   /transl_table=11
FT                   /gene="hemB"
FT                   /locus_tag="Rv0512"
FT                   /product="PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE
FT                   HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH)"
FT                   /function="INVOLVED IN PORPHYRIN AND HEME BIOSYNTHESIS (AT
FT                   THE SECOND STEP) [CATALYTIC ACTIVITY: 2 5-aminolevulinate =
FT                   porphobilinogen + 2 H2O]."
FT                   /EC_number="4.2.1.24"
FT                   /note="Rv0512, (MTCY20G10.02),len: 329 aa. Probable hemB,
FT                   delta-aminolevulinic acid dehydratase (EC 4.2.1.24),
FT                   equivalent to 46723|HEM2_MYCLE DELTA-AMINOLEVULINIC ACID
FT                   DEHYDRATASE from Mycobacterium leprae (329 aa). Also highly
FT                   similar to many e.g. P54919|HEM2_STRCO from Streptomyces
FT                   coelicolor (330 aa); HEM2_ECOLI|P15002 from Escherichia
FT                   coli (323 aa), FASTA scores: opt: 942, E(): 0, (47.6%
FT                   identity in 317 aa overlap); etc. Contains PS00169
FT                   Delta-aminolevulinic acid dehydratase active site. BELONGS
FT                   TO THE ALADH FAMILY. COFACTOR: ZINC."
FT                   /db_xref="GOA:O33357"
FT                   /db_xref="HSSP:1B4K"
FT                   /db_xref="InterPro:IPR013785"
FT                   /db_xref="UniProtKB/Swiss-Prot:O33357"
FT                   /func_characterised="identical sequence"
FT                   /protein_id="CAB10749.1"
FT                   /translation="MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGID
FT                   EPRPITSMPGVVQHTRDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDPDGIL
FT                   NVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVAQAE
FT                   SGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGD
FT                   RRTYQQEPGNAAEALREIELDLDEGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSG
FT                   EYAMIRAAAANNWIDERAAVLESLTGIRRAGADIVLTYWAVDAAGWLT"
XX
SQ   Sequence 990 BP; 148 A; 304 C; 361 G; 177 T; 0 other; 391090938 CRC32;
     atgagcatga gttcctatcc gcggcagcga ccgcgccggc tccgctccac cgtcgcgatg        60
     cgccgtctgg ttgcgcaaac ctcgttggag ccaaggcatt tggtgctgcc gatgttcgtt       120
     gccgacggca ttgacgagcc gcggccgatt acctccatgc cgggcgtggt acagcacacc       180
     cgggattcgc tacgtagggc cgcggcagcc gcggtggccg ccggcgtggg tgggctgatg       240
     cttttcggcg tgccgcgcga ccaggacaag gacggtgtcg gttcggcggg catcgacccc       300
     gacgggatcc tcaacgtcgc ccttcgcgat ctggccaagg acctgggtga ggccacggtg       360
     ttgatggccg acacctgtct ggacgagttc accgaccacg ggcactgcgg tgtgctcgat       420
     gaccggggcc gggtcgataa cgacgccacc gtggcccgct atgtggaact ggctgtggcg       480
     caagcggaat cgggcgccca cgtggtcgga cccagtggga tgatggatgg ccaggtagcc       540
     gcgatccggg acggtttgga cgccgccggc tacatcgatg tggtgatctt ggcctacgcc       600
     gcgaagtttg cttcggcgtt ctacggcccg ttccgcgagg cggtgagctc tagcctgtcc       660
     ggggatcggc gcacctacca gcaggagccg ggcaacgccg ccgaggcgct gcgtgagatc       720
     gagctcgatc tcgacgaagg cgccgacatt gtgatggtca aacccgcgat gggctacctc       780
     gatgtggtgg cggccgcggc ggacgtctcg ccggtcccgg tggccgccta tcaggtctcg       840
     ggagagtacg cgatgattcg tgcggcggcg gccaataatt ggatcgatga gcgtgccgcg       900
     gtgctagagt cgctgaccgg tatccggcgt gccggcgccg acatcgtgct cacctactgg       960
     gcggtagacg cggcgggctg gcttacgtga                                        990
//
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