spacer
spacer
EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   CAB08903; SV 1; linear; genomic DNA; STD; PRO; 1551 BP.
XX
PA   BX842577.1
XX
DE   Mycobacterium tuberculosis H37Rv Probable anthranilate synthase component I
DE   trpE (GLUTAMINE AMIDOTRANSFERASE)
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..1551
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT   CDS             BX842577.1:76646..78196
FT                   /transl_table=11
FT                   /gene="trpE"
FT                   /locus_tag="Rv1609"
FT                   /product="Probable anthranilate synthase component I trpE
FT                   (GLUTAMINE AMIDOTRANSFERASE)"
FT                   /function="Involved in tryptophan biosynthesis pathway (at
FT                   the first step). SUPPOSED TETRAMER OF TWO COMPONENTS I AND
FT                   TWO COMPONENTS II: COMPONENT I (Rv1609|trpE) CATALYZES THE
FT                   FORMATION OF ANTHRANILATE USING AMMONIA RATHER THAN
FT                   GLUTAMINE, WHEREAS COMPONENT II (Rv0013|trpG) PROVIDES
FT                   GLUTAMINE AMIDOTRANSFERASE ACTIVITY [CATALYTIC ACTIVITY:
FT                   CHORISMATE + L-GLUTAMINE = ANTHRANILATE + PYRUVATE +
FT                   L-GLUTAMATE]."
FT                   /EC_number="4.1.3.27"
FT                   /note="Rv1609, (MTCY01B2.01, MTV046.07), len: 516 aa.
FT                   Probable trpE, anthranilate synthase component I (EC
FT                   4.1.3.27). FASTA best: TRPE_CLOTM|P14953 anthranilate
FT                   synthase component I from Clostridium thermocellum (494
FT                   aa), E(): 0, (42.6% identity in 498 aa overlap). Some
FT                   similarity to Rv2386c|MTCY253.35, E(): 6.3e-17; and
FT                   Rv3215|MTCY07D11.11c, E(): 5.7e-15. BELONGS TO THE
FT                   ANTHRANILATE SYNTHASE COMPONENT I FAMILY."
FT                   /db_xref="GOA:P67001"
FT                   /db_xref="HSSP:1K0E"
FT                   /db_xref="InterPro:IPR015890"
FT                   /db_xref="UniProtKB/Swiss-Prot:P67001"
FT                   /func_characterised="identical sequence"
FT                   /protein_id="CAB08903.1"
FT                   /translation="MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLA
FT                   ANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLRAL
FT                   QVTLELLATADRQSEPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLAT
FT                   DVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSR
FT                   PEPRHRAQRTVEEYGAIVEYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNP
FT                   SPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEK
FT                   ELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGE
FT                   GRTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAI
FT                   RTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC"
XX
SQ   Sequence 1551 BP; 271 A; 478 C; 536 G; 266 T; 0 other; 4101111445 CRC32;
     gtgcacgccg acctcgcagc caccacctcg cgtgaggatt tccgcctcct ggcggccgag        60
     caccgggtgg ttccggtgac tcgcaaggtc ttggccgaca gcgagacgcc gctgtcggcc       120
     taccgcaagc tcgccgccaa tcgcccgggt acgttcctgc tggagtcggc cgagaacggc       180
     cggtcgtggt cgcgatggtc gtttatcggt gcgggggcgc caacggcgtt gaccgtgcgt       240
     gaggggcaag cggtatggct gggtgccgtg cccaaggacg ctcccactgg cggagacccg       300
     ctgcgggcgc tgcaggtgac cttggagctg ctggctacgg cggatcgtca gtccgagccg       360
     ggtcttccgc cgctgtcggg tggcatggtc ggtttcttcg cctatgacat ggtgcgacgg       420
     ctggaacgat tgccggaacg ggccgtcgat gacctctgcc tgccggacat gctgctgttg       480
     ctggccaccg atgtggcggc ggtcgatcac cacgagggca ccatcacgtt gatcgccaac       540
     gccgtgaact ggaacggcac cgacgagcgg gtcgactggg cctacgacga cgcggtcgct       600
     cggctggacg tgatgaccgc agcgctcggc caaccactac cgtcaaccgt ggccaccttc       660
     agccgacccg agccgcgcca ccgtgcgcaa cgcaccgtcg aagaatatgg tgcgatcgtc       720
     gaatacttgg tggatcagat tgcagccggt gaagcgttcc aggtggtgcc ctcgcagcgc       780
     ttcgagatgg acaccgatgt cgatcccatc gacgtgtacc gaattctgcg ggtaaccaac       840
     ccaagtccct acatgtatct actgcaggtg ccgaatagtg atggtgcagt ggacttttcg       900
     attgttggat ccagtccgga ggcgctggta acggtccacg aaggctgggc gacgacgcat       960
     ccgatcgccg gaacccggtg gcgcggaagg acagacgacg aggacgtgct tctggaaaaa      1020
     gagctgctgg cggacgacaa agaacgtgcc gagcatctga tgctggtcga cctcggccga      1080
     aacgacctgg gtcgggtctg cacgccgggc actgttcggg tcgaggatta cagccacatc      1140
     gagcggtaca gccacgtgat gcacctggtg tccacggtga ccgggaagct cggcgaaggg      1200
     cgcaccgcgc tggacgcggt gaccgcctgc tttccggccg gcacgctgtc gggcgcgccg      1260
     aaggtgcggg cgatggagct gatcgaagag gtggagaaga cacgccgcgg cctttacggc      1320
     ggtgtcgtcg gttaccttga cttcgccggc aacgctgact tcgccatcgc catccgcacc      1380
     gcgctgatgc gtaacggcac ggcttatgtc caggcaggcg gtggtgtggt ggccgactcc      1440
     aacggatcct acgaatacaa cgaggcgagg aacaaggctc gggctgtgct caacgcgatc      1500
     gctgccgccg agacgctggc cgctccgggc gcgaaccgca gtggctgcta a               1551
//
spacer
spacer