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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   CAB03694; SV 2; linear; genomic DNA; STD; PRO; 1536 BP.
XX
PA   BX842572.1
XX
DE   Mycobacterium tuberculosis H37Rv PROBABLE SUCCINATE-SEMIALDEHYDE
DE   DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD1
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..1536
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT   CDS             complement(BX842572.1:279605..281140)
FT                   /transl_table=11
FT                   /gene="gabD1"
FT                   /locus_tag="Rv0234c"
FT                   /standard_name="gabD2"
FT                   /product="PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE
FT                   [NADP+] DEPENDENT (SSDH) GABD1"
FT                   /function="INVOLVED IN 4-AMINOBUTYRATE (GABA) DEGRADATION
FT                   PATHWAY [CATALYTIC ACTIVITY: SUCCINATE SEMIALDEHYDE +
FT                   NAD(P)(+) + H(2)O = SUCCINATE + NAD(P)H]."
FT                   /EC_number="1.2.1.16"
FT                   /note="Rv0234c, (MTCY08D5.30c), len: 511 aa. Probable
FT                   gabD1, succinate-semialdehyde dehydrogenase [NADP+]
FT                   dependent (EC 1.2.1.16), equivalent to AL022486|MLCB1883_6
FT                   PROBABLE ALDEHYDE DEHYDROGENASE from Mycobacterium leprae
FT                   (457 aa), FASTA scores: opt: 2617, E(): 0, (85.7% identity
FT                   in 455 aa overlap). Also highly similar to
FT                   Q55585|GABD|SLR0370 PROBABLE SUCCINATE-SEMIALDEHYDE
FT                   DEHYDROGENASE from Synechocystis sp. strain PCC 6803 (454
FT                   aa), FASTA scores: opt: 1676, E(): 0, (55.8% identity in
FT                   455 aa overlap); and similar to others e.g.
FT                   GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase from
FT                   Escherichia coli (482 aa), FASTA scores: opt: 929, E(): 0,
FT                   (36.5% identity in 452 aa overlap); etc. Note that similar
FT                   to other cytosolic aldehyde dehydrogenases with EC number:
FT                   1.2.1.3. Also similar to Rv0768|aldA semialdehyde
FT                   dehydrogenase from Mycobacterium tuberculosis (489 aa); and
FT                   gabD2|Rv1731|MTCY04C12.16 POSSIBLE SUCCINATE-SEMIALDEHYDE
FT                   DEHYDROGENASE [NADP+] DEPENDENT from Mycobacterium
FT                   tuberculosis (518 aa). Contains PS00070 aldehyde
FT                   dehydrogenases cysteine active site. BELONGS TO THE
FT                   ALDEHYDE DEHYDROGENASES FAMILY. Could start at different
FT                   site by homology. Note that previously known as gabD2."
FT                   /db_xref="GOA:P71989"
FT                   /db_xref="HSSP:1AG8"
FT                   /db_xref="InterPro:IPR015590"
FT                   /db_xref="UniProtKB/Swiss-Prot:P71989"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /func_characterised="similar sequence"
FT                   /protein_id="CAB03694.2"
FT                   /translation="MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFV
FT                   QTHPAKDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQTSFAQRARW
FT                   ANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYAENAEALLADEPADA
FT                   AKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQCALY
FT                   LADVIARGGFPDGCFQTLLVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKP
FT                   TVLELGGSDPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFV
FT                   ARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRPGWFYP
FT                   PTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGSNAWTRDETEQRR
FT                   FIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSAHGIREFCNIKTVWIA"
XX
SQ   Sequence 1536 BP; 277 A; 527 C; 499 G; 233 T; 0 other; 2844009703 CRC32;
     atgcgatcgg tgacatgttc cgccacgctg gtcctgcccg tgatagagcc caccccagcc        60
     gataggaggc cccgacacct cctgctcggg agcgctggcc acgttagtgg caggctggac       120
     accggacgat ttgtgcaaac ccacccagca aaggatgtca gcgtgcccat cgccaccatc       180
     aacccggcta ccggcgaaac agtcaagaca ttcactgcgg cgaccgatga cgaagtcgac       240
     gcggcaatag cccgggccca ccggcggttc gccgactacc gccagaccag cttcgcccag       300
     cgcgcccggt gggccaatgc caccgccgac ttgctggaag ccgaggccga ccaggccgcc       360
     gcgatgatga cgctcgagat gggcaagacg ctggccgcgg ccaaagccga ggcactgaag       420
     tgcgccaagg gttttcgcta ctacgccgaa aacgccgagg cgttgctggc cgacgaaccc       480
     gccgatgcgg ccaaggtcgg ggcgtcggcg gcctacggcc gataccagcc gctcggggtg       540
     atcctggcgg tgatgccatg gaacttcccc ctgtggcaag cggttcggtt cgccgcaccg       600
     gcactgatgg ccggaaacgt cggcctgctc aagcacgcgt cgaacgtgcc gcaatgcgcg       660
     ctgtacctgg ccgacgtcat cgcccgaggc ggcttcccgg acggctgctt ccagacgttg       720
     cttgttagct cgggagccgt cgaagccatc ctgcgtgatc cccgggtcgc ggcggccacg       780
     ctgaccggaa gcgagccggc cggccaatcg gtgggcgcta tcgccggtaa cgagatcaag       840
     ccgaccgtgc tcgagctcgg cggcagcgac ccgttcatcg ttatgccgtc ggccgatctg       900
     gacgccgcgg tcagcaccgc cgtcaccggc cgggtgcaga acaacggcca atcctgcatc       960
     gccgccaagc ggttcatcgt ccacgccgac atttacgacg atttcgtcga caagttcgtc      1020
     gcgcggatgg cggcgttacg ggtcggcgac ccgaccgacc cggacaccga cgtgggcccg      1080
     ctggccaccg agcagggccg caacgaggtt gccaagcaag tcgaggatgc tgccgcggcg      1140
     ggcgcggtga tccggtgcgg cggaaagcgt ctcgaccggc cgggctggtt ctacccgccg      1200
     accgtgatca ccgacatctc caaggacatg gctctctaca ccgaggaggt cttcggtccg      1260
     gtcgcctcgg tgttccgcgc ggcgaacatc gacgaggccg tcgagatcgc caacgccacc      1320
     accttcgggc tgggatccaa cgcctggacc cgcgacgaga ccgagcaacg acgcttcatc      1380
     gacgacatcg tggcgggcca ggtttttatc aacggcatga cggtgtccta tcccgaattg      1440
     ccgttcggcg gggtcaagcg ctcgggctat ggccgggaac tgtccgcaca cgggatacgc      1500
     gagttctgca acatcaagac cgtctggatc gcctag                                1536
//
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