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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   CAB01479; SV 1; linear; genomic DNA; STD; PRO; 630 BP.
XX
PA   BX842577.1
XX
DE   Mycobacterium tuberculosis H37Rv PROBABLE
DE   CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE PGSA2
DE   (PGP SYNTHASE) (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE)
DE   (3-PHOSPHATIDYL-1'-GLYCEROL-3'PHOSPHATE SYNTHASE)
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..630
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT   CDS             BX842577.1:337823..338452
FT                   /transl_table=11
FT                   /gene="pgsA2"
FT                   /locus_tag="Rv1822"
FT                   /product="PROBABLE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE
FT                   3-PHOSPHATIDYLTRANSFERASE PGSA2 (PGP SYNTHASE)
FT                   (PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE)
FT                   (3-PHOSPHATIDYL-1'-GLYCEROL-3'PHOSPHATE SYNTHASE)"
FT                   /function="THOUGHT TO BE INVOLVED IN CARDIOLIPIN
FT                   BIOSYNTHESIS; GENERATES CARDIOLIPIN FROM
FT                   PHOSPHATIDYLGLYCEROL AND CDP-DIACYLGLYCEROL [CATALYTIC
FT                   ACTIVITY : MAY BE: PHOSPHATIDYLGLYCEROL +
FT                   PHOSPHATIDYLGLYCEROL -> CARDIOLIPIN + GLYCEROL, OR:
FT                   CDP-DIACYLGLYCEROL + GLYCEROL 3-PHOSPHATE = CMP +
FT                   3-(3-PHOSPHATIDYL)-GLYCEROL 1-PHOSPHATE]."
FT                   /EC_number="2.7.8.5"
FT                   /note="Rv1822, (MTCY1A11.21c), len: 209 aa. Probable pgsA2,
FT                   CDP-diacylglycerol--glycerol-3-phosphate
FT                   3-phosphatidyl-transferase (EC 2.7.8.5) (see citation
FT                   below), integral membrane protein, equivalent to
FT                   AL008609|MLCB1788_17 phosphatidyltransferase from
FT                   Mycobacterium leprae (206 aa), FASTA score: (76.6% identity
FT                   in 205 aa overlap). Also highly similar or similar to
FT                   others e.g. CAB88885.1|AL353861 putative
FT                   CDP-diacylglycerol--glycerol-3-phosphate
FT                   3-phosphatidyl-transferase from Streptomyces coelicolor
FT                   (215 aa); AAC44003.1|U29587 phosphatidylglycerol phosphate
FT                   synthase from Rhodobacter sphaeroides (227 aa);
FT                   NP_405431.1|NC_003143
FT                   CDP-diacylglycerol--glycerol-3-phosphate
FT                   3-phosphatidyltransferase from Yersinia pestis (182 aa);
FT                   P06978|PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate
FT                   3-phosphatidyltransferase from Escherichia coli (181 aa),
FT                   FASTA scores: opt: 252, E(): 2.8e-09, (29.7% identity in
FT                   175 aa overlap); etc. Also similar to
FT                   Rv2746c|PGSA3|MTV002.11c
FT                   CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE
FT                   3-PHOSPHATIDYLTRANSFERASE (PGP SYNTHASE) from Mycobacterium
FT                   tuberculosis (209 aa). Contains PS00379 CDP-alcohol
FT                   phosphatidyltransferases signature; and PS00075
FT                   Dihydrofolate reductase signature. BELONGS TO THE
FT                   CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY."
FT                   /db_xref="GOA:P63753"
FT                   /db_xref="InterPro:IPR004570"
FT                   /db_xref="UniProtKB/Swiss-Prot:P63753"
FT                   /func_characterised="identical sequence"
FT                   /protein_id="CAB01479.1"
FT                   /translation="MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAIL
FT                   VFSGVSDWADGKIARLLNQSSRLGALLDPAVDRLYMVTVPIVFGLSGIVPWWFVLTLLT
FT                   RDALLAGTLPLLWSRGLSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLACGWA
FT                   FLIWGMYAYLWAFVLYAVQMTMVVRQMPKLKGRAHRPAAQNAGERG"
XX
SQ   Sequence 630 BP; 92 A; 169 C; 211 G; 158 T; 0 other; 3709363986 CRC32;
     atggagccgg tgctcacgca gaatcgggtg ctgactgtcc ccaacatgtt gagcgttatt        60
     cgcctcgcgc tcatcccagc attcgtctac gtcgtgctca gcgcgcacgc caatggctgg       120
     ggggtagcga tcctggtgtt cagtggcgtt tcggactggg ctgatggcaa gattgcacgg       180
     ctactaaacc agtcatcgcg gctgggcgcg ctgctggacc cggccgttga tcgcctctac       240
     atggtcactg ttcctatcgt gtttggcctg agcggcatcg tgccgtggtg gtttgtcctt       300
     acgttgctga cccgcgatgc gctgctggct gggacgctgc cgctgctatg gagccgtgga       360
     ctgtcagcgc taccggtgac ctacgtcggt aaggcagcga ctttcggctt catggttggc       420
     tttccgacca ttctgttggg gcaatgcgat ccattgtgga gccatgtgct gctggcctgt       480
     ggttgggcat tcttgatctg gggtatgtat gcctacttgt gggccttcgt gctgtatgca       540
     gtgcagatga cgatggtggt gcggcagatg cctaagctca agggcagggc tcatcggccg       600
     gcggcccaga acgctggtga acgtggctga                                        630
//
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