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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   CAA98087; SV 1; linear; genomic DNA; STD; PRO; 1170 BP.
XX
PA   BX842576.1
XX
DE   Mycobacterium tuberculosis H37Rv PROBABLE ACETYL-CoA ACETYLTRANSFERASE
DE   FADA4 (ACETOACETYL-CoA THIOLASE)
XX
OS   Mycobacterium tuberculosis H37Rv
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..1170
FT                   /organism="Mycobacterium tuberculosis H37Rv"
FT                   /strain="H37Rv"
FT                   /mol_type="genomic DNA"
FT   CDS             BX842576.1:102819..103988
FT                   /transl_table=11
FT                   /gene="fadA4"
FT                   /locus_tag="Rv1323"
FT                   /product="PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA4
FT                   (ACETOACETYL-CoA THIOLASE)"
FT                   /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID
FT                   DEGRADATION [CATALYTIC ACTIVITY: 2 ACETYL-CoA = CoA +
FT                   ACETOACETYL-COA]."
FT                   /EC_number="2.3.1.9"
FT                   /note="Rv1323, (MTCY130.08), len: 389 aa. Probable fadA4,
FT                   acetyl-CoA acetyltransferase (EC 2.3.1.9), equivalent to
FT                   THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase
FT                   from Mycobacterium leprae (393 aa), FASTA scores: opt:
FT                   2218, E(): 0, (87.0% identity in 392 aa overlap). Also
FT                   highly similar to others e.g. CAB70629.1|AL137242 probable
FT                   acetoacetyl-CoA thiolase from Streptomyces coelicolor (401
FT                   aa); T51772 acetyl-CoA C-acetyltransferase (EC 2.3.1.9)
FT                   [validated] from Alcaligenes latus (392 aa); etc. Some
FT                   homologies indicate ATA start codon. Contains PS00098
FT                   Thiolases acyl-enzyme intermediate signature, PS00737
FT                   Thiolases signature 2, and PS00099 Thiolases active site.
FT                   BELONGS TO THE THIOLASE FAMILY."
FT                   /db_xref="GOA:P66926"
FT                   /db_xref="HSSP:1PXT"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="UniProtKB/Swiss-Prot:P66926"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /func_characterised="identical sequence"
FT                   /protein_id="CAA98087.1"
FT                   /translation="MIVAGARTPIGKLMGSLKDFSASELGAIAIKGALEKANVPASLVE
FT                   YVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGIDAIALADQLIRAREFD
FT                   VVVAGGQESMTKAPHLLMNSRSGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQRNDV
FT                   DMFTRSEQDEYAAASHQKAAAAWKDGVFADEVIPVNIPQRTGDPLQFTEDEGIRANTTA
FT                   AALAGLKPAFRGDGTITAGSASQISDGAAAVVVMNQEKAQELGLTWLAEIGAHGVVAGP
FT                   DSTLQSQPANAINKALDREGISVDQLDVVEINEAFAAVALASIRELGLNPQIVNVNGGA
FT                   IAVGHPLGMSGTRITLHAALQLARRGSGVGVAALCGAGGQGDALILRAG"
XX
SQ   Sequence 1170 BP; 213 A; 353 C; 414 G; 190 T; 0 other; 1286453120 CRC32;
     gtgattgttg ctggcgcgcg tacacccatc ggcaagttga tgggctccct gaaggatttc        60
     agcgccagcg agctgggtgc catcgccatt aagggcgccc tggagaaggc caacgtgccg       120
     gcgtccttgg tcgagtacgt gatcatgggc caggtgttga ccgcgggtgc cgggcaaatg       180
     cccgcacggc aggcggcagt ggcggccggc atcggttggg atgtccctgc gctgacgatc       240
     aacaagatgt gcctgtccgg catcgacgca atcgcgctgg ctgatcaact cattcgggcc       300
     agagagttcg acgtggtggt ggccggcggt caggagtcga tgacgaaggc gccccacctg       360
     ttgatgaata gccggtcggg ttacaagtac ggcgacgtta cggttttgga ccacatggcc       420
     tacgacggtc tgcacgacgt gttcaccgat cagccgatgg gcgcgctcac cgagcaacgc       480
     aacgacgtcg acatgttcac ccgctccgaa caggacgagt acgcggctgc gtcccaccaa       540
     aaggcggccg cggcatggaa ggacggcgta ttcgccgacg aggtgatccc ggtgaacatc       600
     ccgcagcgca cgggcgatcc actgcagttc accgaggacg aggggatccg cgccaacacc       660
     accgccgccg cgctggccgg tctgaagccg gcgttccgtg gcgacggcac catcaccgcc       720
     gggtcggcgt cacagatctc cgacggtgcg gccgcggtgg tggtcatgaa ccaggaaaag       780
     gcccaggaac tggggctgac ctggctagcc gagatcggcg cccacggtgt ggtggccggg       840
     ccggattcca cactgcaatc gcagccggcc aacgcgatca acaaggcgct ggatcgcgag       900
     ggcatctcgg tggaccagct cgacgtggtg gagatcaacg aggcgttcgc tgcggtggca       960
     ttggcctcga tacgcgaact cgggctgaac ccccagatcg tcaacgtcaa cggtggtgcg      1020
     attgccgtcg ggcatcccct cggcatgtca gggacgcgaa tcacgctaca tgcggcgctg      1080
     cagttggcac gccggggatc gggcgtcggg gttgccgcat tgtgcggggc tggcgggcag      1140
     ggcgacgcac tgatattgcg ggccggatag                                       1170
//
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