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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   ABX81307; SV 1; linear; genomic DNA; STD; PRO; 867 BP.
XX
PA   CP000896.1
XX
DE   Acholeplasma laidlawii PG-8A thymidylate synthase
XX
OS   Acholeplasma laidlawii PG-8A
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales; Acholeplasmataceae;
OC   Acholeplasma.
OX   NCBI_TaxID=441768;
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..867
FT                   /organism="Acholeplasma laidlawii PG-8A"
FT                   /strain="PG-8A"
FT                   /mol_type="genomic DNA"
FT   CDS             complement(CP000896.1:723822..724688)
FT                   /codon_start=1
FT                   /transl_table=11
FT                   /gene="thyA"
FT                   /locus_tag="ACL_0691"
FT                   /product="thymidylate synthase"
FT                   /function="this enzyme catalyzes the reductive methylation
FT                   of dUMP to dTMP with concomitant conversion of
FT                   5,10-methylenetetrahydrofolate to dihydrofolate:
FT                   5,10-methylenetetrahydrofolate + dUMP = dihydrofolate +
FT                   dTMP. This provides the sole de novo pathway for production
FT                   of dTMP and is the only enzyme in folate metabolism in
FT                   which the 5,10-methylenetetrahydrofolate is oxidised during
FT                   one-carbon transfer. The enzyme is essential for regulating
FT                   the balanced supply of the 4 DNA precursors in normal DNA
FT                   replication"
FT                   /EC_number="2.1.1.45"
FT                   /db_xref="GOA:A9NG27"
FT                   /db_xref="InterPro:IPR000398"
FT                   /db_xref="UniProtKB/Swiss-Prot:A9NG27"
FT                   /func_characterised="identical sequence"
FT                   /protein_id="ABX81307.1"
FT                   /translation="MKQYLDLARHIMENGTLKSDRTGTGTKSIFGYQMFFDLKDGFPLL
FT                   TTKKTFLKGIIHELLWFIKGDTNIKYLVDNNVGIWTDWPYKNYMNSSEYQGESIKEFSD
FT                   KIRQSDEFAKKWGDLGPVYGSQWRNFNGVDQIEYIINTLKTNPDSRRMVLSAWNPAEIG
FT                   QMMLPPCHTLIQFYVVDNKLSLQLYQRSGDVFLGIPFNIASYAVFLMMVAQVTGFELGS
FT                   FVHTIGDAHIYTNHFDQINLQLTRTPRRLPILKINKSITRLEDFKYEDFELVGYDPYPP
FT                   IKGVVAV"
XX
SQ   Sequence 867 BP; 295 A; 133 C; 155 G; 284 T; 0 other; 3592033158 CRC32;
     atgaaacagt atttagattt agcccgtcat atcatggaaa atggtacatt aaaatcagat        60
     cgtacgggca ctggaaccaa atcaattttt ggttaccaga tgttcttcga tttaaaggat       120
     gggtttccac tcctaaccac taagaagaca tttttaaaag gtattattca tgaattatta       180
     tggtttatta aaggggatac caacatcaag tatcttgtag ataataatgt tggcatctgg       240
     acggactggc catataaaaa ttatatgaat tcttcagaat atcaaggaga atccattaag       300
     gaattctcag ataaaattcg tcaaagtgat gagtttgcta aaaaatgggg tgatttaggc       360
     cctgtttatg gttcccagtg gcgtaatttt aatggtgtag atcaaattga atatattatt       420
     aatacactaa aaacaaaccc agattccaga cgtatggttt tatctgcgtg gaatccagca       480
     gaaatcggtc aaatgatgtt acctccatgt catacattaa ttcaatttta tgttgtagat       540
     aacaagttgt ccttacaact ataccaacgt agtggtgatg tattcttagg cattccattt       600
     aatattgcat cttatgctgt atttttaatg atggttgcac aagtaactgg atttgaatta       660
     ggtagttttg tacataccat tggagatgca catatttata caaatcattt tgatcaaatt       720
     aacttacaac ttacaagaac gccaagacgt ttaccaatat taaaaatcaa taaatcgatt       780
     acaagacttg aagacttcaa atatgaagac tttgaacttg taggttatga tccatatccg       840
     ccaattaaag gcgtggttgc tgtatga                                           867
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